lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEDDDRPRKYPKLNHDEVQEGSEPVMTGAVGAVHDDDAESADSDNRASPSNDRIDNDVKQACDEEGQDAHGKDGPPTLSKNQLKKLKRKEHWEAMREQRKVKRKEKLVAKRERRRAALEQAKQEGAEATEETRKAFESTQKKFQRSTLLPVTLVLDCSYDDLMLDKERVSLGAQITRSYSDNSRAPFRSHLVVSSFNKLLKERFDTVLGKTHENWKGVRFLQEDFAEAAEMAKEWMQGPKGGQLAGVFADKADAKPEDGEIVYLSSDSPNILTELKPYSTYIIGGLVDKNRHKGICYKSAVAKGIKTAKLPIGEYIQMAHRQVLATNHVVEIMIRWLELGDWGKAFIQVIPQRKGGKLKSADHESEDQTPRESVEAVEAEPDGEGAAAEAGEGGKE
The following text describes a protein:
Function:
Not known. Binds to the sorting sequence of cytochrome b2.
Miscellaneous:
MISCELLANEOUS: Present with 4910 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MFLRSVNRAVTRSILTTPKPAVVKSSWRVFTVANSKRCFTPAAIMRNQETQRVGDILQSELKIEKETLPESTSLDSFNDFLNKYKFSLVETPGKNEAEIVRRTESGETVHVFFDVAQIANLPYNNAMDENTEQNEDGINEDDFDALSDNFANVNVVISKESASEPAVSFELLMNLQEGSFYVDSATPYPSVDAALNQSAEAEITRELVYHGPPFSNLDEELQESLEAYLESRGVNEELASFISAYSEFKENNEYISWLEKMKKFFH
The following text describes a protein:
Function:
Required for synthesis of pyridoxal-5-phosphate from vitamin B6 (By similarity). Important for bud site selection.
Miscellaneous:
MISCELLANEOUS: Present with 6580 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTSTLHTTKKVLSIQSHVIHGYVGNKAATFPLQYRGWDVDVLNTVQFSNHSGYAHFTGFKCSTEELVDIVEKGLIGSLRIKYDAVLSGYLPNVQALQKVAGIVGQLCEGSENVKWILDPVLGDNGRLYVDRECVAVYQDILQNFKIFLATPNQFEMELLVGMSIRTLDDAKQAFKLFHKKYPRVSRIVVTSLELSEFLSNDTYVVAGFDCSASEEIFFYEIPKINAKFSGSGDLISAMLTDSLLGDRRCTQLSLSASLGQVLWLVTSILQKTYDLNIAERGPQDSTIDIKDLKLIQCRDILKQDLIPSIGKPKTIKI
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MADSRELPIFNFADDATQIEDIKKHLNTRGANIAVAGPELVPNLTEIVKNAHLVGASPIEAENVLASIASLFLAVPEDKSYELVDIFCNQLTPAHFKGPGIGSPAAAAIRVLSNLFRGYTRMPKIQERIFSTLLDLCREARVISEMGVNQATLTEYFTRWESDSKTRITILRKLHAALIADNRADHAAKVMIALLALYTEADAELAVEDAQECVRTAVVDPKSFSFDHIVRLSAVRQLEKKDPAMHKALQLFATGTYKDYQSFVAAHPSFVSEKLHVDEAVLVKKIRLLTLMSIAEKDQTIPLPLLSTELGISDGEELEEFIIEAIQVNAISGKLNEKARTLQVTTFQHRSFGREEWVTLQQRIKSLIAHVKQSHENIKNVNETVTAH
The following text describes a protein:
Function:
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA.
Sequence:
MSSWVHLLLLALLAAWLRSGVARGDALPAALVELVRNSPISSIEDLQLLLLTDTVDEQDESAAANGGHRLPRSLDAQPAQQALCKVRTEVVEVTRAMLDRSNANFLLWPPCVEVQRCSGCCNTKSLQCVPVVTHTRYLQVLKIEYINKRPTYAKAVVSVVDHVECRCQLAPRLPASKKKSSRRQHSHLHRNQTFSQSPVQEQVKLHPKDELHQLEELKQNQRGHLEDLLEQHWSSRGDTFRQPGEGYSLAKEDTSRSGDAVFFAPHWVHNSTRLLGAEEQTEKQEDAERKDEKVSEDNKTFSTGDNVGLEATRELEDYVNGLEKTKGKDNTESTHIQTHIQQTKDDKSMFLKSHTRGLYQQVTENPREDALIERLGSRFQPTKEPNPEPRRRENETPEVERILQMEEEKLEAERKELLLLHKRLDQEKEVLRQQQNRREEEERLREEEAEDGQHHSVQTVTQKPEILTTTTRKPSAPTVPRLLLRPNHIKKRMKKNRKRISKAAMRAMLM
The following text describes a protein:
Function:
G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway. Regulates baseline blood pressure in females and protects against cardiovascular stress in males. Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, cilium membrane; Multi-pass membrane protein. Note=Associates with the basal membrane of Bergmann glia cell primary cilia.
Domain:
The N-terminal region is required for constitutive signal transduction.
Sequence:
MRWLWPLAVSLVVVLTVGLSGVSGAATSSLGGHRAKVQEQQSRPRRGTKDEGPKEVQHYVPEEWAEYPKPIHPAGLQPTKTLEATSPNPDKDGATPGNGQELRVNLTGTPSQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMMLAVPELLLWQLAQEPAPTAGTVDSCIMKPSADLPESVYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKPECRAGRHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASDSSATVSADSKLKAEVSSSIYFHKPRESPPLLPLGTPC
The following text describes a protein:
Function:
Transcriptional regulator that binds to its own promoter and thus may play a role in the regulation of the cotranscribed genes Rv1827 and Rv1828. Can also bind several promoter regions of genes that are essential, including ftsZ. Binds to the imperfect everted repeat sequence CTCAA through its winged-HTH motif.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Domain:
Contains an N-terminal DNA-binding domain, a linker region and a C-terminal effector binding domain. Dimerization is mediated via the C-terminal domain.
Sequence:
MSAPDSPALAGMSIGAVLDLLRPDFPDVTISKIRFLEAEGLVTPRRASSGYRRFTAYDCARLRFILTAQRDHYLPLKVIRAQLDAQPDGELPPFGSPYVLPRLVPVAGDSAGGVGSDTASVSLTGIRLSREDLLERSEVADELLTALLKAGVITTGPGGFFDEHAVVILQCARALAEYGVEPRHLRAFRSAADRQSDLIAQIAGPLVKAGKAGARDRADDLAREVAALAITLHTSLIKSAVRDVLHR
The following text describes a protein:
Function:
Part of the MTV complex that associates with the HipHop-HOAP complex to form the terminin telomere-capping complex involved in telomere maintenance and prevention of telomere fusion. As part of the MTV complex binds single stranded DNA in a sequence-independent manner, protecting it from degradation.
Miscellaneous:
MISCELLANEOUS: Multiple telomeric fusions result in multicentric linear chromosomes that resemble little trains of chromosomes, hence the name 'verrocchio', the name of an Italian train named after the artist.
Subcellular Localization:
Nucleus. Chromosome. Chromosome, telomere. Note=Localizes to euchromatic telomeres of polytene chromosomes. Telomere localization is not dependent on peo/pendolino. Telomere localization is dependent on cav/HOAP, tea and moi/modigliani.
Sequence:
MDFNQSFEDIESQLDNFVIRKNQQSEKSTGKCGPEVHDNVPLTISQIERATQDPENENVFITDDVHPIHFCTCIIYAFVTGNGTHNESFMKFMIDDGTGSLEASITKKPFNGRVISSLYSEASSLASSEAYKSIAVSMMRLLQVSMEYIDPTRISRGHSLFLRGRPNRFRGKMGLDAFQFFIDSGRSRNMEIGFVDYLTDWQRRHKTMQNTTNK
The following text describes a protein:
Function:
Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body (By similarity).
Subcellular Localization:
Cytoplasm, P-body. Note=Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.
Sequence:
MSLPLRNPLDSVSLERALEDLIVRFIINVPPEDLATVERELFHFEEAQWFYTDFVKLTNPHLPNMKFKTFASYVISLCPLVWKWQDVNPEEALQKFSKYKKSIPVRGAAIFNETLNKILLVKGTESDSWSFPRGKISKDEDDVDCCIREVMEEIGFDLTNYVLEDQYIERNIGGKNYKIYLVKGVPQDFAFKPQVRNEIEKIEWRDFWKLSRSIHKSNNKFYLVSSMVKPLSLWVKKQKQIQGEEQLKQYAEEQLKLLLGIGTQEEAADPGRDLLNMLQSSVGQKKPLVFSDDESQASISTSAPTTVPPAPSTANSQSVQPIAAGAYAGYPFPFPQYPIPGMQTINPFQFVQSSHQGVFATHSTFTTSHQYPQAQAPQTQQPVPGAVVYPVQSQLQQAYQPPHTPVVKPSVIEDRAPHSKQLLELLKNPRKPEVEDESTAKTLLKLLKNPTKENRTSANTVPSSKGAVSGPSGGRSISGQSIDTANLPSGMASSMGAKSTAIPLYSPRSSLSEMTLPDEPLGGYEEFESSSEEEQGEELAYMNLQEPTSSVMESNAKVENNTLDNISHVDTSGNLSTRSLQSEKTEKSKPTAKPKIKLLKRGETLTPLTPSISSQTATSESSAAGPTVPSEKDVSSRIQNSQGNELLDVLKSKAQPEPSVASTSPAKELLNTLNKPQGSVYQNLLFGANHRKSDDESSPRHSPVSQQARTHEFLNLLKRPQAKAENEELQSVLLTPPANSGMVQNSSTLPNIPYGNLHQDQAAALLFPQQPPQFQQPYAATNTNSKELLAILRKPASNQQKQLHEQTPANPVDQPTTLASEQQNLVKQQISNPSQSLQQGTPLQQPQPQHTQSPSNLHVTGNTAAAQELLGMLRKSRVVP
The following text describes a protein:
Function:
Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.
Sequence:
MDDLLREFLTETSESLDTVDNQLVKFEQEPNNAKILDNIFRLVHTIKGTCGFLGLPRLEALAHAGETLMGKFRDGMPVTGQAVTVILSSIDRIKEILAGLEATEAEPEGTDRDLIDKLEAMVEQGMAAMSASASPIASGSAQPMPAAGSAAAVADAPPLVPEAPAAAAPAKDMTTGSLIDQTLERPLRPGEVSLDELERAFRETAIEAPIPAPIVKAEVKAEPAPAPAPVAKEAAKEAAKPAAKEKAAPKKSMADEGASEGDRIANQSIRVNVDTLEHLMTMVSELVLTRNQLLEISRRNEDTEFKVPLQRLSNVTAELQEGVMKTRMQPIGNAWQKLPRIVRDLSSELGKQIELEMHGADTELDRQVLDLIKDPLTHMVRNSADHGLETPAERLAAGKGEQGTIRLSAYHEGGHIIICIADNGRGLNTERIKAKAISSGLVTEAELEKMSEAQIHKFIFAPGFSTAAAITSVSGRGVGMDVVRTNIDQIGGTIDIKSVAGEGSSVTIKIPLTLAIVSALIVEAAGDRFAIPQLSVVELVRARANSEHRIERIKDTAVLRLRNKLLPLIHLKKLLKIDDGAASDPENGFIVVTQVGSQTFGIVVDGVFHTEEIVVKPMSTKLRHIDMFSGNTILGDGAVIMIIDPNGIAKALGAAGSSAHDMGDENGAHHIGSGEQTTSLLVFRAGSSQPKAVPLGLVTRLEELPADKIEFSNGRYMVQYREQLMPLVAMESVTVASQGAQPILVFADDGRSMGLVVDEIIDIVEERLNIEVGGSSQGILGSAVIKGQATEVIDVGHFLPMAFADWFTRKEMKPSMHSQSVLLVDDSAFFRNMLAPVLKAAGYRVRTAPTAQEGLAALRAQSFDVVLTDIEMPDMNGFEFAEVIRSDNNLGAMPIIGLSALVSPAAIERGRQAGFHDYVAKFDRPGLIAALKEQTAGAAGASELSRAAA
The following text describes a protein:
Function:
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSSIKKTLAFSLGTFFSRITGLVRDIILAKTFGASSTLDAYYVSIVFPFFLRRTFAEGAMSSAFMAIYKKLKNKEEKAQFTSAVLTSLGLVTLLIVFLSEVFPYFMASIFATGADEEVKSLAADLIRLTAPFITIVFVWAVFYSVHNASHRYFLPALTPMFSNVGVIVGCLFGDVRWAAAGFTIGGLAALLVLLPFGKFRYRPTFKGLGEFYRLFFGTFMTMAVSQVTTLIDVNVASFLDPGSLSLIQLSSRLYQLPLGIFGVAVSTVALSTLSESEGDFHENLKDFISKSLFLTLPSSIGLMALSERIISLLFGYGAFTHEDVKKSAQILFMYAIGLCFVSLFNLLSRAYHASKEVKTPFFATLLVSAVNISLDVILGFTMGASGIALATSVSYIAGFVFLTLRMKPSFDKKIFKISLASAVMGTVILLLRGSFKGNLGTIFLVLIGVFVYVLFSKLLKIEELEEILRRGSH
The following text describes a protein:
Function:
Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the aldol condensation between the acetyl group attached to the acyl-carrier-protein AcpK (Ac-AcpK) and a beta-ketothioester polyketide intermediate linked to one of the consecutive thiolation domains of PksL.
Subcellular Localization:
Cytoplasm.
Sequence:
MVSAGIEAMNVFGGTAYLDVMELAKYRHLDTARFENLLMKEKAVALPYEDPVTFGVNAAKPIIDALSEAEKDRIELLITCSESGIDFGKSLSTYIHEYLGLNRNCRLFEVKQACYSGTAGFQMAVNFILSQTSPGAKALVIASDISRFLIAEGGDALSEDWSYAEPSAGAGAVAVLVGENPEVFQIDPGANGYYGYEVMDTCRPIPDSEAGDSDLSLMSYLDCCEQTFLEYQKRVPGANYQDTFQYLAYHTPFGGMVKGAHRTMMRKVAKVKTSGIETDFLTRVKPGLNYCQRVGNIMGAALFLALASTIDQGRFDTPKRIGCFSYGSGCCSEFYSGITTPQGQERQRTFGIEKHLDRRYQLSMEEYELLFKGSGMVRFGTRNVKLDFEMIPGIMQSTQEKPRLFLEEISEFHRKYRWIS
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
Sequence:
MVTAPSFTEEDPAMSPPATPELHQDEAQVLEELSAKGKPSLSLQRIQSPGSGLQNIGNSCYLNAVLQCLTHTPPLADYMLSQEHSQRCCYPEGCKMCAMEAHVTQSLLHSHSGGVMKPSEILTSTFHKHRQEDAHEFLMFTLNAMHESCLRGCKQSETSSKDSSLIYDIFGGQMRSQIKCHHCQGTLDSYDPFLNLFLDICSAQSVKQALEDLVKLEELQGDNAYYCGRCREKMPASKTTKVQTASKVLLLVLNRSYDFGGDKLNRVVSYPEYLDLQPYLSQPTAGPLPYALYAVLVHDGVTCSSGHYFCYVKASHGKWYKMDDSKVTRCDVSSVLSEPAYLLFYVQQTDLEKVNVDVSVGRVHGVLHPESQQKKTRKKKHKRSSCTEAVYMPRENRENTATKETSLGEGKVLQEQNHQKAGQNLKTTKVNLSANGTVIHQPRYTANWGRNAPDKDDQPGHSGDRLLTTQGSMNTGQLCGHGGSQRSKKRKNKNKQGQRPLLVC
The following text describes a protein:
Function:
Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF.
Subcellular Localization:
Cell projection, invadopodium. Cytoplasm, cytoskeleton.
Sequence:
MTANGPCESVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPGGGEEAGAVQAVCLKSHLGRYLSADKDGQVSCDSEKPDADCRFLVVAHDDGRWSLQSEPHRRYFGGTEDRLSCFAQAISPAEKWTVHIAMHPQVNVYSLSRKRYAHLSARQDEIAVDRDVPWGVDSLITLVFEDRRYGLRTADHRFLRRDGRLLDKPDPDTGFALEFRSGRVAFRDGDGRYLAPSGPSGTLRAGKATRVGKDELFVLEQSCPQVVLRAGNDRNVSTRQGMDLSANQDEESDQETFQLEINRDTKKCAFRTSTGKYWTLTPSGGIQSTASVKNSSCYFDIEWLDRRITLKAANGKYVTAKKNGQLAASVETVGETEHFLMKLINRPIIVLRGEHGFIGCRKVTGTLDSNRSSYDVFQLEFNDGAYNIKDSTGKYWMVGNESSVTSSSDTPVDFFFEFCDYNKVAIKTNGRYLKGDHAGVLKASADSIDPSTLWEY
The following text describes a protein:
Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation. May interact with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Mediates poly(A) site selection. Binds RNA in a calcium-dependent manner. Exhibits endonuclease activity with an ability to nick and degrade linear as well as circular single-stranded RNA that leaves RNA 3' ends with hydroxyl groups, thus mediating processing of the pre-mRNA as a prelude to the polyadenylation. Involved in the post-transcriptional control, probably via poly(A) addition, of the responses of plants to stress, especially genes mediating tolerance to oxidative stress. Plays a role in the regulation of salicylic acid (SA) production via the control of messenger RNA 3' end processing, thus being a key component of programmed cell death and plant immune responses required for resistance to virulent Pseudomonas syringae pv tomato DC3000 (Pst).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localized in the cytoplasm when not in complex or when associated with CPSF100, but move to the nucleus when associated with the cleavage and polyadenylation specificity factor (CPSF) subunits CPSF160 or CPSF73s.
Sequence:
MEDADGLSFDFEGGLDSGPVQNTASVPVAPPENSSSAAVNVAPTYDHSSATVAGAGRGRSFRQTVCRHWLRGLCMKGDACGFLHQFDKARMPICRFFRLYGECREQDCVYKHTNEDIKECNMYKLGFCPNGPDCRYRHAKLPGPPPPVEEVLQKIQQLTTYNYGTNRLYQARNVAPQLQDRPQGQVPMQGQPQESGNLQQQQQQQPQQSQHQVSQTLIPNPADQTNRTSHPLPQGVNRYFVVKSNNRENFELSVQQGVWATQRSNEAKLNEAFDSVENVILIFSVNRTRHFQGCAKMTSRIGGYIGGGNWKHEHGTAQYGRNFSVKWLKLCELSFHKTRNLRNPYNENLPVKISRDCQELEPSVGEQLASLLYLEPDSELMAISIAAEAKREEEKAKGVNPESRAENPDIVPFEDNEEEEEEEDESEEEEESMAGGPQGRGRGRGIMWPPQMPLGRGIRPMPGMGGFPLGVMGPGDAFPYGPGGYNGMPDPFGMGPRPFGPYGPRFGGDFRGPVPGMMFPGRPPQQFPHGGYGMMGGGRGPHMGGMGNAPRGGRPMYYPPATSSARPGPSNRKTPERSDERGVSGDQQNQDASHDMEQFEVGNSLRNEESESEDEDEAPRRSRHGEGKKRR
The following text describes a protein:
Function:
May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MARVEEAHRITDLTYKGLVENFAPAVRNLISMGKAYEKSLAAVSSTARGYFEALMKLGEQANATRGAPELGGCLIQIAEIFRNIQMQHEETVQSFHKELIVPLEQKVEQDTRSMPKWLRTPKILHKTYTQEYKAKAETFEKAKSELKKHRKKSNRKDPHKYEAKESQLIRAATETQSKLDDCRAHGLTKALVEERKRYCFVVDRHCAIVKHYMVYHSKAQNLLRQKLDSWVEACDNPNILTKRAQDVLDRALQGPSSDMMTMPRRGSQIMLDSDFADMNGGRGDPYLRDDRYRGEGYSRDGFATMPERRQGSPLRRPVSPVSQHAPIQELFRDAPPPVPGPAQHDVSIYGTMRRPAPQGRPAPQGRLAPQGRPMTPQGRSMSSSSWVGPKLDYYQAPRQQQQTTIYGTMRGPPRRSQSTFQDDRYHSPPPNAMSVREPRRDFHEPLMVDTYSNTLPNPRRGQNQRQPRPSQSASVFEPPQQQSGQMARSVSAVPASRRKVRALFPHKAGDSTNQLSFNEGDTISLLIDHPRDGWHFGENDKTKRRGWFPYSYTQPATSDAPPPPVQAAQPMAAPLRPSVSMGNLLNNSAYREPSRLPSPDYQDTQAVQQSPMRREARPRSVAGDSLLTVAEQSDDFRHPNGDYQQSQGVDPYRQPPPRSDYQQPQPGDYRQPPPRSDYQQPMRQPPPPQEYRDRNDGYRDPVDARYIPRQSESSYRQSVSSEYSQPADHRPRGVSYGGEPDYRSGQTEYAQPVNGRSSVSNDRQNGFGEGGHPPPSTQPATPQEENPARNPFANVRLKKTVTNDRSAPII
The following text describes a protein:
Function:
Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MPNEIFPWKIRVDESRGLAGNSGTKKSNHEALSRLQSPLNSPKLQPIGSPQASRKTSGSGSSAPLYPKWSGALSLASSRAASPAPSDSFPTFGYSQLGGLENSSKGSALFNSANSIGTPYLSSRNSNSANEASAMAFHNVSPPSGAESSSESKSFSASGKGNKADTSAEPSLDAFNSTQIKAGSTANSNSTPVEPGEDTIPTAIVVKNIPFSLEKDTLLDHFKQLGIPRPYAFNYHYDNGIFRGLAFANFYRPEEAQVVVQTLNGYEINGRRLRVEWKRQLPAAEREKVEKAKKRQAEERRRKQQYKMFEVSFTDQGLNLNDTGTLETYSRLLLFAHQCIPSREITFETTSKDGNLLNAIRIFCLYFDLDYYARPNGEVLKLVVTHPNKKNTSVSQSQPASPNLRFNMPAPLATRFLQEHSLNGTKSAPITPPPSFAVPLTNQLRSIDDKIYGNESPLQKASTLSSPFNSKNDNDASTSASKQSFGVSHF
The following text describes a protein:
Function:
Subunit F6, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MLIANAKVQTSTINPPVKDSSESAIPVHTKPVQDTLVDLQAVTSPTGSSLNETASRLNSILIRPAVDFAYSNVIDQNATEGLNKKKYTQISNANDLASNFVDSYAGSTTNDAHGDVTTNITQVSSQTSEVISSYEVDTQNHDAFDEHTPQVVACEETVNMADAIMTTPEVSSVFQGEELRCLSEDVNVNVNIAQAQNYPQPLPQHFPNWSSNVIADKQSSDGQILNQAFPESLPDGSAIQDISEAFCSRSGEVCQVSPSTEYIAGVSLFKSTDDLSVAGTVSACKAVKVDGLSEMSANVQSSISLKDPVLAQTDILVEENQTEAAEMLPEEQLDPIQRLFLHKIREYSTKSQASAGPVDAGADYEKAFSEELSKLQRLYGGGDLTNFPGFKFSEPVLDESDSK
The following text describes a protein:
Function:
Essential for thermotaxis by sensing environmental temperature. Receptor-activated non-selective cation channel involved in detection of sensations such as temperature. Involved in heat nociception by being activated by warm temperature of about 24-29 degrees Celsius.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTSGDKETPKREDFASALRFLMGGCAREPEMTAMAPLNLPKKWARILRMSSTPKIPIVDYLEAAESGNLDDFKRLFMADNSRIALKDAKGRTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLATELNKVKSLRVMGQYRNVIDIQQGGEHGRTALHLAAIYDHEECARILITEFDACPRKPCNNGYYPIHEAAKNASSKTMEVFFQWGEQRGCTREEMISFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMFEMQPMEKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRLTDFAEQVANCQTQAQLKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDSEKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLHRDHTGRNPLQLAAMSGYTETIELLHSVHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMGCKLVYNVLDMSAIDYAIYYKYPEAALAMVTHEERANEVMALRSDKHPCVTLALIASMPKVFEAVQDKCITKANCKKDSKSFYIKYSFAFLQCPFMFAKIDEKTGESITTASPIPLPALNTMVTHGRVELLAHPLSQKYLQMKWNSYGKYFHLANLLIYSIFLVFVTIYSSLMMNNIELKAGDNKTMSQYCNMGWEQLTMNLSQNPSVASQIRLDSCEERINRTTAILFCAVVIVVYILLNSMRELIQIYQQKLHYILETVNLISWVLYISALVMVTPAFQPDGGINTIHYSAASIAVFLSWFRLLLFLQRFDQVGIYVVMFLEILQTLIKVLMVFSILIIAFGLAFYILLSKIIDPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVNTYYRDQLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPHVWLQRVDKMELIEYPNETKCKLGFCDFILRKWFSNPFTEDSSMDVISFDNNDDYINAELERQRRKLRDISRMLEQQHHLVRLIVQKMEIKTEADDVDEGISPNELRSVVGLRSAGGNRWNSPRVRNKLRAALSFNKSM
The following text describes a protein:
Function:
Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin enhances tetrodotoxin-sensitive sodium current in rat dorsal root ganglion neurons.
Subcellular Localization:
Secreted.
Domain:
The cysteine framework is III (CC-C-C-CC). Classified in the M-1 branch, since 1 residue stands between the fourth and the fifth cysteine residues.
Sequence:
MLKMGVLLFTFLVLFPLTTLELDTDRPVERHAAIKQDLKPQERRGIRLHAPRDECCEPQWCDGACDCCS
The following text describes a protein:
Function:
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. May be required to embody the molecular ruler of the complex (By similarity).
Sequence:
MDAQDEDNPFTNLETTVDVTEEIQDWRFLSNVEKDQGTYTIPKRGQKDFEPDGTNKQHSALDLSRKAMFDALSVERLISAKHAIIATWNAQNGMSCVEKAHGPLFKTMGTADSQNRMWLLPEETLYLVERGSMECWSEEGLPMSLQAVYSASIPLCGSLENYLVYAHLRRCGFSVIRSNLVPVKEDEYRCDSKIMNFKDLLFLGLGKASQILQTFNFRKLAFPFSKRRRQSILLHDTFYTYEEVYHDLQIVRGYVPIACNLITSSDSLFQITFHAYKPSASFKKSALSEPDFRICVVSSQDTLLPTIFEIDALFSSTPLRQNMPQHMFQRLKEGYRNIIIAIVDYGVISYIRLSDVCFEEKVYTDFSKKGSKRKRVSKKFQQLV
The following text describes a protein:
Function:
Acyltransferase with lysophosphatidic acid acyltransferase (LPAAT) activity. Fatty acyl substrates include 18:0-acyl-CoA, 16:0-acyl-CoA, 17:0-acyl-CoA and 14:0-acyl-CoA. Responsible for the acyl-CoA-dependent introduction of saturated very long chain fatty acids (VLCFAs) into phosphatidylinositol, transferring saturated FAs with 18 to 26 carbon atoms. Responsible for the incorporation of stearate into phosphatidylinositol. Overexpression has an effect on chromosome stability. Regulates phosphorylation and expression of glycerol-3-phosphate acyltransferase SCT1.
Miscellaneous:
MISCELLANEOUS: Present with 2010 molecules/cell in log phase SD medium.
Subcellular Localization:
Lipid droplet.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MLHQKIAHKVRKVVVPGISLLIFFQGCLILLFLQLTYKTLYCRNDIRKQIGLNKTKRLFIVLVSSILHVVAPSAVRITTENSSVPKGTFFLDLKKKRILSHLKSNSVAICNHQIYTDWIFLWWLAYTSNLGANVFIILKKSLASIPILGFGMRNYNFIFMSRKWAQDKITLSNSLAGLDSNARGAGSLAGKSPERITEEGESIWNPEVIDPKQIHWPYNLILFPEGTNLSADTRQKSAKYAAKIGKKPFKNVLLPHSTGLRYSLQKLKPSIESLYDITIGYSGVKQEEYGELIYGLKSIFLEGKYPKLVDIHIRAFDVKDIPLEDENEFSEWLYKIWSEKDALMERYYSTGSFVSDPETNHSVTDSFKINRIELTEVLILPTLTIIWLVYKLYCFIF