lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG.
Subcellular Localization:
Mitochondrion.
Domain:
The GGQ domain interacts with the peptidyltransferase center (PTC) of the large ribosomal subunit to trigger nascent chain hydrolysis.
Sequence:
MRSRVLWGAARWLWPRRAVGPARRPLSSGSPPLEELFTRGGPLRTFLERQAGSEAHLKVRRPELLAVIKLLNEKERELRETEHLLHDENEDLRKLAENEITLCQKEITQLKHQIILLLVPSEETDENDLILEVTAGVGGQEAMLFTSEIFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTVAILPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEEINKRQNARKIQIGSKGRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDYLLDELVQSLKEYADYESLVEIISQKV
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Required for the assembly of both SST3A- and SS3B-containing OST complexes.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
GHFRCPGAGVLGRRRKMEAGAAARAWSLLWLLLPLLGPVCASGPRTLVLLDNLNLRETHSLFFRSLKDRAFELTFKTADDPSLSLIKYGEFLYDNLIIFSPSVEDFGGNINVETISTFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDVSDLGQHTLIVADPENLLKAPTIVGRSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVVFSGSLDFFSDAFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIEQLSNGRWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLHSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIFSTVFLHMKEKEKSD
The following text describes a protein:
Function:
Has a role in meiosis.
Sequence:
MLWRILTCCKSPEEDKDEHKKKPPNVGHAHLSVVSPLNELASEKSRSSLCIEWTIDSLRQFVQQLSVRQNMSKDRREALTYFINSYNDLFHDVYYGDGRSMSKTEEAQTIVTFTIGSYLYKYTHPSELFWQRLSDNMANIEDDGTCTEAQLAFRKRAALSKLGHPAFHFLPMNNKESFHYAWSLFTSTYFQKAATVSPSPNQQPVDSVANPQLRKASEITTISSRSDVDILLGKFKALIQESPDEHCNSWIQRIYITCVLPRNHYIYLLNEQVDFLTSIEIMKNQVTEGKLCLLNEDLGTLN
The following text describes a protein:
Function:
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Subcellular Localization:
Nucleus. Cytoplasm.
Domain:
The DNA-binding domain is intrinsically unstructured; The coiled coil mediates dimerization.
Sequence:
MTSPAAAQSREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRRSRRNTSASDEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLGRASEVEVKNEIVANVGKREILHNTEKEQHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLGTLAGATYEEQVQSQILESSSLPENTVQVESNEVMGAPDDRTRTPLEPSNCWSDLDGGNHTENVGEAAVTQVEEQAGTVASCPLGHSDDTVYHDDKCMVEVPQELETSTGHSLEKEFTNQEAAEPKEVPAHSTEVGRDHNEEEGEETGLRDEKPIKTEVPGSPAGTEGNCQEATGPSTVDTQNEPLDMKEPDEEKSDQQGEALDSSQKKTKNKKKKNKKKKSPVPVETLKDVKKELTYQNTDLSEIKEEEQVKSTDRKSAVEAQNEVTENPKQKIAAESSENVDCPENPKIKLDGKLDQEGDDVQTAAEEVLADGDTLDFEDDTVQSSGPRAGGEELDEGVAKDNAKIDGATQSSPAEPKSEDADRCTLPEHESPSQDISDACEAESTERCEMSEHPSQTVRKALDSNSLENDDLSAPGREPGHFNPESREDTRGGNEKGKSKEDCTMS
The following text describes a protein:
Function:
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates.
Subcellular Localization:
Secreted. Note=Released from the secretory granules upon mast cell activation.
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
The following text describes a protein:
Function:
Protects sister chromatid centromere cohesion in meiosis I but not through the protection of the cohesin SYN1. Required with SGO2 for full protection of centromeric cohesion during anaphase I. Required to prevent precocious release of pericentromeric cohesins during meiosis. Not necessary for the maintenance of the synaptonemal complex (SC). Not required for monopolar spindle orientation in meiosis I.
Miscellaneous:
MISCELLANEOUS: Knock-down mutants show meiotic defects, reduction in seed set and fertility, and premature separation of sister chromatids before meiosis II, but no defects in vegetative development or growth. The localization of SYN1 and ZYP1 are not affected. Sgo1 and sgo2 double mutants are almost completely sterile and show a premature separation of sister chromatids at anaphase I; MISCELLANEOUS: Shugoshin is Japanese for guardian spirit.
Sequence:
MVRATVLNVGDHASEGVRTNKAKGEKMVLEPPMNSAQRRKLGDITNLQNQKNLMNQGAKHQQQAILISSKENAENLQKENTKLMKVVMERDGIKSDLKKLRIEFQKVQEQNLLLAQANTRILAEFNTSKDQLKVLQHELGCKNGLVMARKMLLKEQTLPCTRHASKVKAQANACGGACKTFQPNDADHEHASGSSNANSLQRNEKANSKRRVSGRKNPANSEVLDIIGRSGETCQMEDNIDNKKLVSDSDNDAENHINDNVQSKRYCAGRQSSSSKTREASQTETLQKVVDAKEIKGDARFSLTKHSDWLKSQEPEPSESLYESRFPLRRRSARLKSQEPEPSESFHDSIETTKRRRSAIRSAMFNIQELGVIQNLNGLPDDQEIAAKARCSAREQSTGSKPEAVEPHDTKEIIGKSRISLRRQSARFNFQELGVTENLNGPHDDQTIAANARCCASEQSIGSKPEAVEPHDIEERIGKIRVSSRRQSANIETPRAIKEPANPPLHDDNVEESSQISCSVSMELKRESKKKPTGDESEEMRKTTVGRPSRQAAEKIKSYKEPSLKEKMRGGF
The following text describes a protein:
Function:
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MVDDTLAIPNTRRFFVNPGWLRTDQVEIDDAAIIHQWERVLRLRAGDRVMLLDGQGLAAIVEITHIDRRRARGQVVARCQASGEPAVTFDLYLALIRPERFEWAIQKAVELGVYRIVPVTFARSLITGRIDEHRLARWQRIATEAAEQAGRGRLPVVAEPQSFAAALTRAHTADLAILLDEQATVHLRTVLPPQPSLRQIAIYSGPEGGIDPAERTAAHQHGIQSVSLGPRILRAETAPLVALAMLQYALQY
The following text describes a protein:
Function:
Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity.
Subcellular Localization:
Peroxisome.
Sequence:
MAAVSVFKPGLFNQKVAVVTGGGTGIGKAISTELLELGCSVVISSRNAERLQKVAKEMRQKIPASSPASVTPVPCNIRNEEEVNNLVSSVLRQYGRIDYLVNNGGGQFSSPVENMTSKGWKAVIDTNLTGTFHCCKEGKLCTHKSDSVFTALCNLYSPMTSLHSIYEEAWGRHSEYHCRHVEGLPWHGVRTTGNTRFVHNAPLSCVMVFPPADRHTGAARAAVDNLTKSLAIEWASSGVRVNAVAPGTIFSKTAMENYKELGPHLFKTSVPFSPAKRLGVPEEISSVVCFLLSPAASFISGATLKVDAGQSLYRTMWEIPDHQAWPEAPEGENLVALKELLEPQSKL
The following text describes a protein:
Function:
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Sequence:
MALLITKKCINCDMCEPECPNEAISMGDHIYEINSDKCTECVGHYETPTCQKVCPIPNTIVKDPAHVETEEQLWDKFVLMHHADKI
The following text describes a protein:
Function:
Receptor for cAMP.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLSLSSYVLNLVGSILCLIGCLFIIGHFFWIPLLRTSLSRIIIYPTFILLLYDMVSFPSFISKTADLYIERSTIICNFQEAIIQYLILSNFIWSVCISVNLLYLCFSPNKNLKKNELLYHLCSWGIPLIVVVITKIPNMISDNGNQCRFKSPNYIKFYLETILFIAFMLFNFIVAFITIKHIISGNLRESETTTTSVLFVNEKKITTKKIVWRLLLYPSILSICYIMTLVLSIYQFSTESYGSGGAYANSINNKRNDKNTESGNSNNNNNSYIEILLYISKAIFLLQGFFNALVYLRSSKLRDRYKKITIFRKIFWRDEADYQSINDGFN
The following text describes a protein:
Function:
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in a peroxiredoxin. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase (By similarity).
Sequence:
MEFISHFLRATSRRTAALGPILQRNRSEIIQKQSLTNRQAFRRYRSSCSTMDTTVHSAGIDETHLVPMSVIQRPIPSVLDEQKVQSLMETIKNETSEDEVPPIDLLWISGSEGGDYYFSFGGCHRFEAYKRLQRPTIKAKLVKSTLGDLYHYMGSSAPKYLA
The following text describes a protein:
Function:
Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).
Sequence:
MVDRGRKPSALASTPGLPPQPQVAFSSDNSRVTATLPTGESVSVLLYGATVVSWKDKNGHEKLWLSEAAKLDGSKPVRGGIPLVFPVFGTAPDHAQTKDLPQHGFARSSRWEFLGKSTSESTPTPTTPAFAATATSAAGAVAAAAADLSVKLDFGLSSSGLSEDARAKWPYAFNAIYSVTLNTDSLTTNLVITNDDERSWECQMLMHTYLRVNDITSVSIHGLENASYVDKTTSPISTSTQTTSALTISSETDRVYTPAGDDPASIPITVFEGDQPKYTVLRDNLANVVVWNPWIEKAQGMADFEPKDGYKNMLCVEPGAVATWQVLEPGDAFEGAQTIVLGGKTQN
The following text describes a protein:
Function:
Has a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MSSPQPINPQPIIPPTQNQQESQADQFFNNIATNPLASAGLSVAQNYLNQGDQLLKSQLGGIFSFDAWRYYFNVNTSFVLKKILMIIMPYPFLGTWERKYVIGEDQSKLYNVPQEDIYAPDLYIPLMGFISYVLAIGFYYGSKGTFTPETLSMTTTLCLILISLEVMILKFLEYMLFNYSSDFRIYLSYVSYVFVPVLMCTFVGSLQIPYLTYIALLFFGTSYAFFLYKTFFGSLASIQTEENKKRIYSICVGVFQIILIFFMMK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MFILVMFAHHIVRCMGVTGRGQDFFHMLLPELRFILSFLESYFVVKTWCLTKKIFYVLTFSQTTIQDLIQIKPQDFSKPSAQAIKDVVNEKYANKIVPGIGLCICMWDLLTATEGLIGHGTGLVNVNIEFRMTVFRPFRGEIIYGRIKSSSPDGIIIDLDFTSEVFVPYQNLFENSSFSQAEGVWVWNSDGTELFLDKGEPVLFRVEQEEWFDQRPTIVQKDEQGNVIEERGTAWRVIGSMNQAGLGPTLWWGEQEEGEDGDAEMDDAEE
The following text describes a protein:
Function:
Phosphorylates aspartate, the first step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.
Sequence:
MTWIVQKFGGTSVGKFPKNICNDIVQQYSQSYDVAVVCSARSTGTKAEGTTTRLIAAADSALLGSDAYNPIIESIREDHLAAAKRDVKNPELLENLNADINGECDQLLRILAAAEIISEISPRTLDSIMAIGEKLSCMYMTAVMRDAGVNARYFDLSHAVTTTNAEDPKFYSDLGRVLGEIITLPGSPNTDSAPVKGNMVPVLTGFFGPVKGGLLSQIGRGYTDLCAALVAVGLDAKELQIWKEVDGVFTADPRKVSTARLLPIITPEEAAELTYYGSEVIHPFTMEQVIKAHIPIRIKNVENPLGGGTIIYPSADGSGNLKTKNNVQDLASSTDSLTSLSSGSFTPQVSAPVDDEKKPTAVTTKSNITVLNVHSNKRTKSHGFLNKIFATLDQQKLVVDLISTSEVHVSMAFHAPDSNLKQAVEELRKYGTVDVKRGMTIVSLIGTRMKAMVGCAGMFFSTLAQAGINIEMISQGANEINISCVIEEKDALKALNVIHQGLLCPRRKI
The following text describes a protein:
Function:
Involved in meiotic recombination in association with MSH5. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. Promotes homologous recombination through facilitating chiasma formation during prophase I. Involved in the control of class I crossovers formation.
Subcellular Localization:
Nucleus. Note=In pollen mother cells during meiosis, localizes to unsynapsed axes during leptotene and zygotene, but is not present on synapsed regions of zygotene nuclei.
Sequence:
MEDDGGERSSFVAGLIENRAKEVGMAAFDLRSASLHLSQYIETSSSYQNTKTLLRFYDPSVIIVPPNKLAADGMVGVSELVDRCYSTVRKVVFARGCFDDTKGAVLIQNLAAEEPLALGLDTYYKQHYLSLAAAAATIKWIEAEKGVIVTNHSLTVTFNGSFDHMNIDATSVENLELIDPFHNALLGTSNKKRSLFQMFKTTKTAGGTRLLRANLLQPLKDIETINTRLDCLDELMSNEQLFFGLSQVLRKFPKETDRVLCHFCFKPKKVTEAVIGFENTRKSQNMISSIILLKTALDALPILAKVLKDAKCFLLANVYKSVCENDRYASIRKKIGEVIDDDVLHARVPFVARTQQCFALKAGIDGFLDIARRTFCDTSEAIHNLASKYREEFNLPNLKLPFNNRQGFFFRIPQKEVQGKLPNKFTQVVKHGKNIHCSSLELASLNVRNKSAAGECFIRTETCLEALMDAIREDISALTLLAEVLCLLDMIVNSFAHTISTKPVDRYSRPELTDSGPLAIDAGRHPILESIHNDFVSNSIFMSEATNMLVVMGPNMSGKSTYLQQVCLVVILAQIGCYVPARFATIRVVDRIFTRMGTMDNLESNSSTFMTEMRETAFIMQNVTNRSLIVMDELGRATSSSDGLAMAWSCCEYLLSLKAYTVFATHMDSLAELATIYPNVKVLHFYVDIRDNRLDFKFQLRDGTLHVPHYGLLLAEVAGLPSTVIDTARIITKRITDKENKRIELNCGKHHEIHRIYRVAQRLICLKYSRQTEDSIRQALQNLNESFTEERL
The following text describes a protein:
Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MAAGTLLLGLALAALAGRGARAGMGACYDGAGRPQRCLPEFENAAFGRRAEASHTCGRPPEDFCPHVGAPAAGAQCQRCDAADPERHHNASYLTDFHSHDDSTWWQSPSMAFGVQYPTSVNITLRLGKAYEITYVRLKFHTSRPESFAIYKRSRAGGPWEPYQYYSASCQKTYGRPEGQYLRPGEDERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPVLQEWVTSTELLISLDRLNTFGDDIFKDPRVLQSYYYAVSDFSVGGRCKCHGHASACGPDAAGRLVCLCQHNTTGTDCERCRPFFQDRPWARGTAEAANECLPCNCSGHSEECTFDRELFRSTGHGGRCLRCRDHTAGPHCERCQENFYRWDRRTPCQPCDCHPAGSLRLQCDDAGTCVCKPTVTGWKCDRCLPGFHSLSEGGCRPCTCNPAGSLGTCDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFCYGHSKVCAAAAGFREHHILSDFRQGAEGWQVGSMGGPEHPARWRPGGLPLNLGDEEELAAPEKFLGDQRFSYGQPLTLTFRGPPGGSPLPVQLRLEGAGLALSLRHSSPSGPRDAGQPGEVQLHFQLQETSEDVDPPLPPFHFQRLLTNLTALRIQASSRGRSPPGQMFLMEVRLTSAQRGLSPPASWVETCSCPKGYTGQFCESCAPGYKRETPLGGPYANCVPCTCNQHGTCDPNTGICLCGHHTEGPSCERCLPGFYGNPFTGRADDCQPCPCPGQSACTTIPESREVVCTHCPPGQRGRRCETCDDGFFGDPLGLSGAPQPCQQCQCSGNIDPNTVGNCDPLSGHCLRCLHNTTGAHCEHCQDGYYGSALAPRPADKCMPCSCNPGGSVSEQRPCDPVTGQCSCLPHVTGRDCGLCSPGFYDLQPGRGCQSCKCHPLGSQEDQCHPKTGQCPCRPGVEGQACDRCQLGFFGFSVKGCRACRCSPLGAASAQCHENSTCVCRPGFVGYKCDRCQDNFFLTASGTHCQECPSCYSLVKEEVAKLKARLTLMEGWLQGSDCGITWGPLDILQGEAPRGDVYQGHHLVQGAREAFLEQVTGLEGAVKAAREQLRALSRKARCAQARAGKTCIQLADLEAALESSEEEILHAATILASLVIPQEGLGQPTNWSHLAAEARVLARSHRATATKIKATAQRALLASNTSYVLLWSLLEGKVALEAQQELEDRYQAVQEAQKELGAAVAEALPEAERVLAAVQQVVTDTALRPASLPVPVALPQAARAGDLDPRLQALEKTVASRERVVTEAARALQATARAALHKAEPLTQLHQEARAALTRASSSVHAATVTVVGARTLLADLEGMKLRFPLPEDQAALMRKAGLVQDRILADARKKTKQAERMLGNAASVSSSARKKGREAELLAKDSAKLAKALLREGKQEYRRAGRLSSQTQATLRQASRQALALGARGRELEEAEQVGAGLSKVERQIRESRLSLEKDIEALTELLDRLGSLDTHQTPAQALNETQRALERLRLQLGPPGALQGKLRLLEQESEQQELQIQSFESNLAEIRADKQNLEAILHSLPESCANQQ
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MPGVETIKSSWADEVELDYGGLPPTTETVENGQKYVTEYKYNKDDKKTKVVRTYKISKQVVPKTVAKRRTWTKFGDSKNDKPGPNSQTTMVSEEIIMQFLNSKEDEKANDPLLDPTKNIAKCRICNGEHWSVNCPYKGTAMDTNMMEKKASAAAAAAVDAPKSGKYVPPFLKDSQKGALGMRGRDDTAAIRISNLSESMTEADLEELVKKIGPQSKMYLARDKNTGLCKGFAYVHFKQRKDAAAAIEILNGHGYDHLILSVEWSKPQNN
The following text describes a protein:
Function:
Dephosphorylating regulator for many key proteins. Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase.
Sequence:
MGQTLSEPVTDKHSLEGGNEHVVFGISSMQGWRISMEDAHSVALHMKNKTVEEAIDFFAVYDGHGGDKVANWCGEHLPKLLEQSEDFQKGDFEAALKQTFVEADKTILEDERFHTDPSGCTATVILRVGRKLYCANAGDSRTVLGARGVAKPLSVDHKPSNDEEKARICAAGGRVDFGRVNGNLALSRAIGDFEFKSSDLPPEKQIVTAVPDVVCHELTDDDEFVILACDGIWDCKTSQQVVEFVRRGITAHLPLQKIAENLMDCCVATDAETTGLGCDNMTVCIVGLLNNMSVEQWMDEIAKRVENNDGPCAPPEYAELPGSGWTNREQDLPNVNMPFRIRRVDMDASLSVNDKNASEDAAAKDSEMLHADSSLAAGFRLKEHFFPLSSSNSRVVESPLPSNAPAVESLENTD
The following text describes a protein:
Function:
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
Subcellular Localization:
Secreted.
Sequence:
MKLLAMAVLLLTICSLEGALVRRQAEELSLQRLVSQYFQTVTDYGKDLVEKAKGPELQAQAKAYFEKTQEQLTPLVKKAGTDLINFLNNFMDLKTQPATQ
The following text describes a protein:
Function:
Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLQFLNRCSRGRGAWLLMALTAFLLELTALYFQHIMLLQPCVMCIYERVALFGILGASLLGAIAPRSPLRYLAIAVWIYSAWKGVQLAWAHTMLQLNPSPFNTCDFFVNFPSWLPLDKWLPAVFAASGDCSERQWQFMSLEMPQWLVGIFAAYLVIAVLVLISQFVKPKRRDLFGR
The following text describes a protein:
Function:
Probable inactive serine protease.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDDKWRESAPVNDIEASSWIRIFRAFDTDHDGLIQCEEMQKTIRDSTYSFGFDHYELQKMSLYLEMREGKPVDFADFCYLMSKCKGYRLREYLFRAALTVTPKNQRIHVFSELQRYKCVPPPIFLIFLSIVQLAFYLYYVVDSSEGVWLSGPIPTMSPLIVSQYHLPELWRLFTYCLINVGIFHIIFNILIQLAIGVPLELVHRWRIYILYFMGVLFGSILSLALDPTVFLCGGAAGSFSLIASHITTIATNFKEMENATCRLPILIVFAALDYVLAVYQRFFAPRIDKVSMYGHLGGLVAGILFTFILFRGSKPSRFYTVSFWVSLVLSGFFIAICITLIAAPSMLH
The following text describes a protein:
Function:
May function as a proteasomal ubiquitin receptor. May promote the deubiquitinating activity associated with the 26S proteasome.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAMFSNARSTTSSSGHIVEFKAGRSRLDAGSADTMRKVVAEPTKGLVYIKQSNDMLIHFCWKNRETGALVDDLIIFPDDAEFKAVTGCPDGKVYMLKFRSSGEMKLFWLQDSTPDVDKDLVRKVNDALNKPPTSRPSASRSSGSTTNADRPSAGGSSIMSGNDFNAPLGGLDQGQLMSLIQSLQGNSSDSLPLTAGSGAAPSSEADCEPTAGEGSSNPLSLDNPAIQNIFKNLGQQQKRQGGVSASLGEALANSTVADVAKNHADELAQHLPASDDPAKELADTVRTPQFRQAADTLGHALQTGQLGPVLSQFGMNDETIAAATQGDLRKFATNLTKAEGGEQDKSAEENPEDDVAREPEAKRNRPDNEDMDVD
The following text describes a protein:
Function:
Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MCRVRWTFVLLSFLVVWLFFLLRKQYISKQLAHKQHPGRIFQTDETMHLAMAACRGKSLTIVKEATTMIKSAIIFSRSRIHVHIFTENLEDEFRKEFATWPLSAKRKFLLTIHPLVYPLDPEELKVMKNWWGPCASFRLFLPTVLDKTDSVLYVDTDVIFLTPPEELWRHFYLFNDRQVAALAPRVGWSFQVPNDNANFIRMQDGKKTQVNSGVFLMNLTRMRQPVFATESESRQKISWNKKLLFPLYRKHKEDMYGDQNLINLVFHYNPDLIYFLPCKYNYHHKFCFDAYRERWCTSAESDGAAVIHGNANTFYNNYAPAFRAISNAMRAYNFERDLERYLLSPMESGLTDPSVEAHEHCGNKTYLFLKNIRKMVKRRRNFSHKPK
The following text describes a protein:
Function:
Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage (By similarity).
Subcellular Localization:
Nucleus. Note=Recruited to DNA damage sites via its interaction with the BRCT domain of TP53BP1.
Domain:
The PWWP domain mediates the interaction with nucleosomes.
Sequence:
MTDAKYVLCRWEKRLWPAKVLARTETSAKNKRKKEFFLDVQILSLKEKIQVKSSAVEALQKSHIENIAAFLASQNEVPATPLEELTYRRSLRVALDVLNERTSLSPESHPVENGSTPSQKGKPDADMASQVSSAPSPSFLSEDDQAVAAQCASKRRWECSPKSLSPLSASEEDLRCKVDPKTGLSESGALGTEVPAPTGDESQNGSGSQLDHGQESTTKKRQRNSGEKPARRGKAESGLSKGDSVAESGGQASSCVALASPRLPSQTWEGDPCAGVEGCDPVESSGNIRPLLDSERSKGRLTKRPRLDGGRNPLPRHLGTRTVGAVPSRRSCSGEVTTLRRAGDSDRPEEADPMSSEESTGFKSVHSLLEEEEEEEEEEEEEEEPPRILLYHEPRSFEVGMLVWLKYQKYPFWPAVVKSVRRRDKKASVLFIEGNMNPKGRGITVSLRRLKHFDCKEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADISYPVRKSIQQDVLGTRFPQLGKGDPEEPMGDSRLGQWRPCRKVLPDRSRAARDKANQKLVEYIVKAKGAESHLRAILHSRKPSRWLKTFLSSNQYVTCMETYLEDEAQLDEVVEYLQGVCRDMDGEMPARGSGDRIRFILDVLLPEAIICAISAVEAVDYKTAEQKYLRGPTLSYREKEIFDNELLEERNRRRR
The following text describes a protein:
Function:
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
Subcellular Localization:
Cytoplasm. Dynein axonemal particle. Note=Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia.
Sequence:
MAKAASSPLEDLDLSGEEVQRLTSAFQDPKFRRMFSEYAEELTDPENRRRYEEEITALERERGVEVRFVHPEPGHVLRTSLDGARRCFVNVCSNALVGAPSSRPSSGSAASGSQWSLPYSLAPGREYAGGRGIRYTVYDVVFHPDALALARRHERFRQMLDATALEAVEKQFGVKLDRRNAKTLKIKYKGTPEAAVLRTPLPGGVPARPEGEPESPLPDFPYPYPGPVAAGSAAIPRPQAPSPPEAVQQPAPTEPRYSVVQRHHVDLQDYRCSRDSAPSTVPHELVVTIELPLLRSAEQAALEVTGKLLCLDSRKPDYQLRLSLPYRVDDSRGKAQFNKARRQLVVTLPVAVTVSLPELAATPEEAADRPGTDGAACASARQGEAGPAGIRAGDGGSDPGRAGAAGADIPAPEAVGGKLVSEPEELDFGGQAISTARIGEEPLPRAGNSPEDGGGGAPWKSSGDLDGRSPTGRGRARPALGVKEHVAGGGTGREPVDRSMVGPGTDRGEPLCPPLQCNQDEESLTLLIQVPCIQPQSLQGEVTPLWYRLCFSTQDLVYYTFFLQFTPENKLSTKEPVASISSNNAVIELAKSPECRGLWREWYYGLNNDSLEERLFINEENVNEFLEEVLSSPFKQTMPLSSPLIEVLQVTDSKIEIHAKLQECDNSEQLHENKEGANEESHLTEKENLEHPTSSTTNSDSSVAVKVLEANSCGLVACLQQGAFDVSQKPFAESKDNLKGPVKIEEKELGGDHPPSSLNKTTGHDTPGFDNLRETNMQDGSVQIIKDHVTHCPFSFQNSLLYDLD
The following text describes a protein:
Function:
Counteracts the antiviral effects of host IFN-gamma. Acts as a soluble IFN-gamma receptor and thus inhibits the interaction between host IFN-gamma and its receptor.
Subcellular Localization:
Secreted.
Sequence:
MRYIIILAVLFINSIHAKITSYKFESVNFDSKIEWTGDGLYNISLKNYGIKTWQTMYTNVPEGTYDISAFPKNDFVSFWVKFEQGDYKVEEYCTGLCVEVKIGPPTVTLTEYDDHINLYIEHPYATRGSKKIPIYKRGDMCDIYLLYTANFTFGDSKEPVPYDIDDYDCTSTGCSIDFVTTEKVCVTAQGATEGFLEKITPWSSKVCLTPKKSVYTCAIRSKEDVPNFKDKMARVIKRKFNKQSQSYLTKFLGSTSNDVTTFLSMLNLTKYS
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAALDFPKFLQNATEIWRSQSSKEKYCIQNAYELDKDVICLGMKIIDWRNSTVDHCIESIQGCLKSSRSDSKSASSAEDSRQKGNQLFQKRNYRGALECYTKSVQVAPHDGKDTLALAHANRSAALFHLGRYKASIQDIDEALTRGYPTNKHVKVLQRKGQCFLKLHNLSEAEEEFSKALRCLDSITGEDKKRREIKILLQESSNPTSVSFGDQLDIPDEDIKEKSSMLANASSAVTCKHQEGNGRFLEATRDIAAGELLIKEKPYAAIILKEEESSHCHHCFEQCSPIPCPNCIHARYCSSRCRSDSLTQYHSIECGTEQLLQQVSVFSRLSLRILITAGREELSNDIRKPKTSSSQPSSSSTSTSLTTAKGSSSGYLDGGLVNYESIVGLEAHWFNHSHEELIQYTVTSILLAKCFYRELVSLKTCETLSEEELIAEIASLLLLHTRQLKSNSHAITEVRPSEGENTAGKSAGGTVEEISQFRVATAVYPTVSMMNHACIPNIIPSFRKGILCVRATKKIMHGDEIQHCYGPQVGHMTTSDRQQALLNQYCFTCRCRACTRDPKSRDNLCMKCPKCGQPLNAMTSICGKCAVWIDVLVLLKEVDDTMITFAELVEMYPAAVKDVTLMRDVISKTKTCHDVLDRILIPPHMHLAVAYNFMAKCHIALQEFKEAAPWLAKAIPTIECRFGRDSIEVANELYKLAQIYFNGKEIAPAMEAIDRALELFIRHYGNSNEEVLVLMKMKACLMNA
The following text describes a protein:
Function:
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MSLSSLSVSLCLWASPFICMSLSLCLCISRSSLGVSLCLWASASLYLCMSLSVSLYVSPYVSGPLFISACLSPCVSASLGHLWVSPYVSGPRLLSISACLSPYLSMRLAPCVSASLCHLWVSPYVSGPRPLSLHVSLLVSLCLSVISGCLPVSLGLGLYLCISLSPCVSVSLSGCLPMSLDLSLHVSLLVSLHLRHLRVSLNVSGPRPLFISASVSLCPWASAPLYLCTTLSLCLCAPLSSLGVSLCLWASLSISASPSLLVSLHLSVISGCLPMSLGSSLYLCISSCLCTSPSLGLSLHLLLLVSLRLSISGCLPKSLGLSLSRHLSPLVSLRLSIPGSLYLCVSLAVCLCAPLISGPWGGVCLYLCISLLVSLRLSVISGCLPVSLGLSISACLSPCVSASVGVSLCLWAPLYLCISLLVSLHPPYLRASGSPFTSASLPVSLGLGASLDLCISLSSCLSASPFLSVSLHLSLSSPPLSLCLCASLYLWGLGVVSSLCLSLPLCLSPPSLGLCLSLPRLSLRVPGLRSPPRPCLSSPGRLSRLRVRPPPPARPSHLVLSALCLRPGWDAAGARPGGPGGRGPRTPTARRSRRRRPPGPRKDPRGRGPRGSGGGGGRGAGRGAAAAGGGPGAGAGAGAAAAARPGAWALRRQRWQRAVTLHPAPPALPPDAADPRVSPDLFWGTYRPHVLFGMKTRSPRSLVAGLMWLVQEPGGGFELRHTCEQSEGLGPFTWERHDGHTFGRQLVRDGPLRLTTEFLKRPGGRHGGDWSWRVTVRTQGAGAPTLLSLFFYVATDGQGRLRPEPAEGDGSRPAGVRGRTEELGDFYLTLLPPTDAEGSGPRHASYDVFSGPSPGLHLLTEAVRSRLVRRARHRPPGGPARRYVGLAGGPAGEGGGPGPRPAAGAAGDPGPAGPRGAGLRVGQRGRGAAGPAGGGGPERGPGPPGGRLRAALRGRLRAGGPRAGPRRAPPGPGGPQRAAGRRGLLPRPRPGPARPRRGGGRGGGRGGGRGAPAALPGGAPVHGHAVALLLPAGLPVGRGLPPAAGAALGPAAEPPGAGPLAGPPQRRRLDRARAGPGRRGPGPGAPRVPAPAGRPRQPAHPLPARGAHAGGGGGRRRRRRPGGRGRVRGGGRGAGGLPAPGLPPPAGLVLLAQPHAGRPGAPVLPLAGPRPRLPPLPQPQDPAVGPGRLPAGLAPVPRGAPPGPALLAGPGGRGAGPPAGGCGAGEAAGLRALAAALRREDGPRGLAALHWAEELGAFADFGNHTPTARLVPAPASAPGGGPPPSPGLVRVAGPTPPRPRYVDALGYVSLFPLLLRLLEPGSARLGPLLDAVEDGGRLWTPYGLRSLAPASPLYGRRNTEHDPPYWRGAVWLNLNYLALGALRHYGGREGPHAARAARLYAALRARLLDNVARQYRATGFLWEQYSDRDGRGQGCRPFQGWTSLVLLIMAEDY