lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MDSDGVSHAPSVAQSAPSWNPALRHEKDHAPAATAKLPSQVKPESSSEEESEEEEEEEDDDEDDEEEEDSDEDDDEEENAPAATAVSGPTPIAVLDGAQDSEDESESPSELTKSTPIVQASQGSMEKRVEVIGAEEEALVNAAQALNISGNPATGQTKAESTDEAESDEDSEEEESSDEEAAAAGEHQADNYEHQGEATALEEAVNESVRVPLVDDAAPESDDWGDSGDPFEIGGLQQDPSLQTPHAEAAGTTVGDDVIGNTTVGGNAGDDLDWGNTEEEDFFGVVANKPVESVEPAQPTQSPGAHVVQAQDAAPAKSEWDLDLDLDEDFLPDNEDGPVIELSDDEGFLDDEPTAPVEQPASTGIGGASRYAPQAAQTSHSVASPYAAPGQFANPPQGSMTRSITTPAGGVYNGYGQNVAYQQQQAARPTMPTSAQSYADKSKGGYASPYDLPDDVVTTRKRTTPRPVISATQPAIPPPRTSSMSSSSAPPRPLPPSNASVASLSPPPSGHSMQGQMTGFPPAVPPKSAPPAKAPSSDFFAELPVTSKPKPPGRYTPQPAAAAQSPSLQGPPQFTQKERTASWSSLRNEVLPDTVGAQPHLRQPEQLPMFPSQPSVPTRQNSLPIPQSTAPPPSSRYSPAPPSVPANNARYSPAPPTAQGGANSRYSPAPPGSQGAAHARYVSEPPTGPARTPSQTYAPRTSSPLAFHSTPHHQENTTNVSEQQLPGHHVTQSADGVPRAPFRSPLEGVSEALELDSTSSDRPPTTARSDTPPPTRSSTSSAIGSPRKKGNYTPQYQPMNPMAPSRSLSQSPATGMKQPGPMYGAAPIAASYGTHIQEATTTNSIPHRRQASLNYECIVPEDERAVDPLQRYKGHPVFAWGLGGTIVTTFPKQIPRYGGGMTAPMVKCSPGEIKIQSVKEIIPLAEDLAKFPGPLKAKSKKKDVLSWLTKRLESLELQIKDPNTEHTLSVDELKRLEEKTLLLKLLQFLVENDGRLEGEAANAAFKNLFSPEADNASDAEGSFSTAADIVGRSRSNTVNTPAEPIDARAIEDLQKMLARGEREKAVWHAVDQRLWGHAMLLSSTLSKDIWKQVVQEFVRNEVKKVGRSNQALAVLYEVFAGNHEDCIDELVPASARAGFQMVSTDGAGAALNAQQGLDKWRETIALILNNRSEGDVSALLSLGKLLSQYGRVEAAHICFILGRSVAHVSGVDDALADLVLIGIDHKQHPTELGVDLEPILLTEVYEFALSLSAQVNSHIMPHLQNYKLAHAYQLAEHGYRTEAQAYCDAIAAAMKATTRTSPYYNLSFIASLDDLSKRLSQSPKDSSSSWISKPSMDRVSTSLMSKFNSFIAGEDDGPSSNAATGTEVGPFAKITGDSPGLTPSHSNADLYADCFCKFKICSFKYIRTKDVIRATEIALRAAGQTFYGVERQPPPQPQLSPPSQRTQAKMQSYSPLRAEHNVSQPSYGNPYMPTPPNEETASASSFGGYQPQQGTGHSFDDPAPPTSSFDEPSYQPYNPDADDMEEDNKPKKKSIMDDDDDDLVARAAALKIGSGSNSKSDADKKADEAFRKAAEADAKRDKENAAKKAGGGWLSGWFKKDPNAAPGPIKAKLGEESSFYYDPDLGKWVNKKGGSSEPERATATPPPPKGPPMGARSASGGMPPPSGPPPSGAGLMKPPTSAPLRSSSMPPPMGLPGSRSSTPGLPSDNEGGPKPPTLARPSFGAASGPPSRPGTGMSNASSIDDLLGAPQARKGAGAKKKKGGRYVDVFPQGQAS
The following text describes a protein:
Function:
Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Nucleus and/or cytoplasm.
Sequence:
MSDDYDPTAVAFKPGDMETDMNTGEPLALEAEAAAKDPAHNEESGEDTNANVESGTLVHQGDEPESIDKEDKVEDGPDTKSDGGVLDEPKDGEQRDDEKKEEHKPENPSEEVAEDDDYVPAAVSEPVEEDSAGGGSVGGTGIPDGAISSLAASTTIPPPSDPNQVGGGASSTSNNNNSGPDNNKRKRLATDTIGILEDRIAANPRDMPAWLDLISTIVRKEKLDESRDIYERFLALYPLSAEIWIEYITLEMDNGEFKRLEQLFGRCLTRLPNLKLWNIYLTYVRRVNVLSSESDKITEARTNIIKAFEFYLDHVGIDRESGNVWFEYLDFIKSKPATTTWEEQQKNDLTRKIYRKAIGIPLNNLSILWTAYTNFEYSLNKATARKFINEKSGSCQNARQCQTVLENLMRGLDRSSVPKSGPRDEFQVRAWKKWIDWEKSNPLGTDNKAETNKRLLYCLKQAVMSLQFVPEIWFLAAEYCFDDPLLKTEALQFLKDGLSLNPNSSLLAFRLAEYYEREADAEKMRTIYDEHIESLGKERQALIEAQGDPEAEPTAEIIKLNTQISIAYSVCMKAVKRFEGIKPGRMVFKKARNTGFATYHIYVASALMEFHHNKNPTVATNVFELGLKYCGSNAAYVQHYLDFLISLHDDTNARALFEKTIPLLGPSDAASLIKSMIKFESDFGEITSVVKLQDRLRQLNPDTSPITIIADRFATSDFDVIRQCDMLQKPKSRTDEDSDSERPSKRARRTSHGNDQGDKMEPFNLPQKIDALLRQLPNSSDYGEATFDPQRLVDLFRDVRIPDGLL
The following text describes a protein:
Function:
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism.
Sequence:
MFPMPQQVLRQNREVVMAEEIGRARMLTLNRPNHLNYLSGKVASTLGHNFEKYENDDNADFVIIKKPHIALVHGMSVGGGASLMAPMKFSVVTEKAFSSTPETNIGFHPDCGFSYMLPRLPGRLGEYLGLTGEKLKGKEVVAAGLATHFVPSQGIRAQIIDKDKSPKWNPSTLDKVHDDQLDLIFKPFEDHDLELQIPIKEEEEESRWRGKYENSSYSSPNQVNIQKAFRSMSSRESVLV
The following text describes a protein:
Function:
Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MAATNPQTEPRSRTLSIHVATWNVASAAPPPDLSDLLQLHTPNLNLDVYVIGLQEMNCGIMSLLSDTAFEDPWSSFFMDVLSPLSFVKVSSVRMQGLLLLVFAKYQHLPFIQILSAKSTPTGLFGYWGNKGGVNIFLKLYGYYVSIINCHLPPHMANNDQRLEHFDRILEMQNFEAQDIPNILDHDLILWFGDMNFRIEDFGLHFVRESIKHQCYSDLWEKDQLSIAKRHDPLLREFQEGPLLFPPTYKFDKNSNNYDTSEKKRKPAWTDRILWRLKRQPQADCHPPTLPAPHFSLVLRSYVSHMMYSISDHKPVTGTFDLELKPLVSAPLITLLPEGPCTTESDLLISYSLASDFLSSPWDWIGLYKVGLRHINDYVSYVWVGDNQVSFGDQLNQVYISLSDIPETEDGFLLFYYSNSLRSVVGISRPFKIQPRSFLEQDSLDEAQPQI
The following text describes a protein:
Function:
Part of the multicomponent carbazole 1,9a-dioxygenase (CARDO), that converts carbazole (CAR) into 2-aminobiphenyl-2,3-diol. Catalyzes the dioxygenation at the angular (C-9a) and adjacent (C-1) positions of carbazole to yield a highly unstable cis-hydrodiol intermediate which is spontaneously converted to 2-aminobiphenyl-2,3-diol. It is also able to attack the angular position adjacent of hetero atom of heterocyclic aromatic compounds such as polychlorinated dibenzo-p-dioxin (DD) and dibenzofuran (DBF). It was also shown that CARDO has the ability to metabolize biphenyl and polycyclic aromatic hydrocarbons, such as naphthalene and phenanthrene.
Sequence:
MANVDEAILKRVKGWAPYVDAKLGFRNHWYPVMFSKEIDEGEPKTLKLLGENLLVNRIDGKLYCLKDRCLHRGVQLSVKVECKTKSTITCWYHAWTYRWEDGVLCDILTNPTSAQIGRQKLKTYPVQEAKGCVFIYLGDGDPPPLARDTPPNFLDDDMEILGKNQIIKSNWRLAVENGFDPSHIYIHKDSILVKDNDLALPLGFAPGGDRKQQTRVVDDDVVGRKGVYDLIGEHGVPVFEGTIGGEVVREGAYGEKIVANDISIWLPGVLKVNPFPNPDMMQFEWYVPIDENTHYYFQTLGKPCANDEERKNYEQEFESKWKPMALEGFNNDDIWAREAMVDFYADDKGWVNEILFEVDEAIVAWRKLASEHNQGIQTQAHVSG
The following text describes a protein:
Function:
Involved in the regulation of mitochondrial distribution and morphology. Required for mitochondrial fusion and mitochondrial network formation.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MAGSTREVVTLQFGHYANFVGTHWWNLQESSFCYDAASSSSPSEINHDVLFREGLTLTGEQTYTPRLIMYDLKGSLNTLKEDGTLYDVLDRDDEVHWMGDVTLHTSETSGKNQFLKDLEKIDKGELPTEEDASSAGTEDSHDEVQETTPHLSTDPLEVFRSKLYNLDGSVSVWSDFLRIHLHPKTVSILSEFAHDPEQDMFDVFSHGQQLLGTQRVSADVEDRLHFFVEDCDSLQGFQMLVDPYNGFGGLAAEVLERMSEDYDNKGILTFGCYPSVFVRRSPIVDYHRLICTVLSVTKLSDNSSLYAPLSVATGLGREPGPVASFPYLSYNPSLHYHTGGILATALDTCTLPYRTRSDAVLMTDLTNTMNYSGRKMAALSARLPFPITLDGSLASSLSQYVAAPDLVSLCPGVREPGRTFMQSVVLRGVPPNRILIPDPAAHADSIFRDCRSANDCLKRYLQHVYPGTLNAGTVVNEPLTVTTPFPHLFHPEIAHDGLVGFKPRSAIQGVEKMPAMTSLSSPSGLQGCLTALHGEVEKVDIRRFHRFLDAGLEEDDFAEAVESLRRLARMYQTSDNEMAEDSDDDSD
The following text describes a protein:
Function:
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Subcellular Localization:
Membrane. Secreted.
Sequence:
MECIKGEGLREPQNLSGSQREPQTEERMDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLALGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNILSQGVLKEDVFSFYYNRDSENAQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIPMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAH
The following text describes a protein:
Function:
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MNIIPCSIKTLKGLYDISGVEVGQHFYWQIGGFQIHAQVLITSWVVITILLGSVIIAVRNPQTIPTDGQNFFEYVLEFIRDLSKTQIGEEYGPWVPFIGTMFLFIFVSNWSGALLPWKIIQLPHGELAAPTNDINTTVALALLTSAAYFYAGLSNKGLSYFEKYIKPTPILLPINILEDFTKPLSLSFRLFGNILADELVVVVLVSLVPLVVPIPVMFLGLFTSGIQALIFATLAAAYIGESMEGHH
The following text describes a protein:
Function:
Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy. Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Preautophagosomal structure. Note=Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells (By similarity). Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner. The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner.
Domain:
Has been proposed to contain 7 WD repeats. This prediction could not be reproduced.
Sequence:
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPPLLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKSIQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKLIRCHQSRGGACGDNIQSYTATVISAAKTLKSGLTMVGKVVTQLTGTLPSGVTEDDVAIHSNSRRSPLVPGIITVIDTETVGEGQVLVSEDSDSDGIVAHFPAHEKPVCCMAFNTSGMLLVTTDTLGHDFHVFQILTHPWSSSQCAVHHLYTLHRGETEAKVQDICFSHDCRWVVVSTLRGTSHVFPINPYGGQPCVRTHMSPRVVNRMSRFQKSAGLEEIEQELTSKQGGRCSPVPGLSSSPSGSPLHGKLNSQDSYNNFTNNNPGNPRLSPLPSLMVVMPLAQIKQPMTLGTITKRTGPYLFGAGCFSIKAPCKVKPPPQISPSKSMGGEFCVAAIFGTSRSWFANNAGLKREKDQSKQVVVESLYIISCYGTLVEHMMEPRPLSTAPKISDDTPLEMMTSPRASWTLVRTPQWNELQPPFNANHPLLLAADAVQYYQFLLAGLVPPGSPGPITRHGSYDSLASDHSGQEDEEWLSQVEIVTHTGPHRRLWMGPQFQFKTIHPSGQTTVISSSSSVLQSHGPSDTPQPLLDFDTDDLDLNSLRIQPVRSDPVSMPGSSRPVSDRRGVSTVIDAASGTFDRSVTLLEVCGSWPEGFGLRHMSSMEHTEEGLRERLADAMAESPSRDVVGSGTELQREGSIETLSNSSGSTSGSIPRNFDGYRSPLPTNESQPLSLFPTGFP
The following text describes a protein:
Function:
Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration.
Subcellular Localization:
Cytoplasm, cytoskeleton, stress fiber.
Sequence:
MACPALGLEALQPLQPEPPPEPAFSEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLDNIILFLRGCKELGLKESQLFDPSDLQDTSNRVTVKSLDYSRKLKNVLVTIYWLGKAANSCTSYSGTTLNLKEFEGLLAQMRKDTDDIESPKRSIRDSGYIDCWDSERSDSLSPPRHGRDDSFDSLDSFGSRSRQTPSPDVVLRGSSDGRGSDSESDLPHRKLPDVKKDDMSARRTSHGEPKSAVPFNQYLPNKSNQTAYVPAPLRKKKAEREEYRKSWSTATSPLGGERPFRYGPRTPVSDDAESTSMFDMRCEEEAAVQPHSRARQEQLQLINNQLREEDDKWQDDLARWKSRRRSVSQDLIKKEEERKKMEKLLAGEDGTSERRKSIKTYREIVQEKERRERELHEAYKNARSQEEAEGILQQYIERFTISEAVLERLEMPKILERSHSTEPNLSSFLNDPNPMKYLRQQSLPPPKFTATVETTIARASVLDTSMSAGSGSPSKTVTPKAVPMLTPKPYSQPKNSQDVLKTFKVDGKVSVNGETVHREEEKERECPTVAPAHSLTKSQMFEGVARVHGSPLELKQDNGSIEINIKKPNSVPQELAATTEKTEPNSQEDKNDGGKSRKGNIELASSEPQHFTTTVTRCSPTVAFVEFPSSPQLKNDVSEEKDQKKPENEMSGKVELVLSQKVVKPKSPEPEATLTFPFLDKMPEANQLHLPNLNSQVDSPSSEKSPVMTPQFKFWAWDPEEERRRQEKWQQEQERLLQERYQKEQDKLKEEWEKAQKEVEEEERRYYEEERKIIEDTVVPFTVSSSSADQLSTSSSMTEGSGTMNKIDLGNCQDEKQDRRWKKSFQGDDSDLLLKTRESDRLEEKGSLTEGALAHSGNPVSKGVHEDHQLDTEAGAPHCGTNPQLAQDPSQNQQTSNPTHSSEDVKPKTLPLDKSINHQIESPSERRKKSPREHFQAGPFSPCSPTPPGQSPNRSISGKKLCSSCGLPLGKGAAMIIETLNLYFHIQCFRCGICKGQLGDAVSGTDVRIRNGLLNCNDCYMRSRSAGQPTTL
The following text describes a protein:
Function:
Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTATGSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRHSVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMVAENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVKPRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRSTVIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRHLGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGRRSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQEGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGSGGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGSDGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVDRGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPMAPQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYMFMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRGLDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYKIKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYVNVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVIFNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASALAAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGDNQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR
The following text describes a protein:
Function:
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.
Sequence:
MSVPQNIGIKAIQVNIPRSYVTQDDLEETEISILGEESRTKIKGKFTKGLGQTALSFCTDHEDTASIAMSAVQKLMDTYGYKPTDFGRLEIGSETAIDRSKSIKSFVMQLFEENHSIMGVDNTNACYGGTAAFLNSLAWIESSQWDGRLALVVCADIAVYDDRAARPTGGCGAVAMVLGPDAPIVFEKGSLTNYFTHSFDFWKPNPANPHPKVDGPLSLTLYYECLENCYMQFRTRHPGTTLDKFDYVVFHTPFQNHIKKCTGRLNFLDQHQDNNDPEIIKTRSEHQTVSQQSHDAAQIFKDKVQPASLMSAMCGNGYTASLYMALSSLIFNRDLTGKRLMMFSYGSGAASSMYVLNVVGDIKFMKDALNLEERLANRVQRKVSDYDHDIKLADQLYRTAPYEPSCSLDLIESGAWYLEKIDDNWRRIYKRKE
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). Required for embryonic cardiac looping and heart chamber development, via promotion of cell-cell junction formation and subsequent attachment between the endothelial and myocardial layers of the heart. Required for the directional migration and delamination of endothelial cell monolayers, by which common cardinal veins form via the lumen ensheathment mechanism of vessel development as they migrate and connect with the heart inflow tract. Required for the formation of filopodia extensions (sprouts) at the initiation of intersegmental vessel development, by acting (via its C-terminus) to facilitate anchoring of the actin cytoskeleton to cell junctions in endothelial cells. Then positively regulates dorsal migration of stalk cells and sprout outgrowth towards the dorsal longitudinal anastomotic vessels (DLAV) via endothelial cell elongation. Following contact with the DLAV, required for intersegmental vessel lumen formation, potentially via facilitating the formation and/or extension of endothelial cell tight junctions that are required during tubulogenesis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction.
Sequence:
MMKQCARRQMTEPVFRVAVLLALCSLSIGVDVHQAQKTPSISSAALQRHKRDWKWDKLYAYEETRPKNPPEKIGKLENTFFSSSTRYILKGDGAKDKFGVTDNGDIVVLAKLDRETQSVYNLSASLLNIHTGELVDKDESFVIVVLDINDNIPVFDSDQSGSISESSRAGTTIMKVKATDADDSSTENGRIDFKLLNGTDLFKIKPNGDLIALKSDLDREKQSQYLIAVQAKDMPEHLTGNSATTVVTINIKDINDNIATFKKERYQFTVKEDLKPGSEIGLLEVEDKDEIQNKDPTFALQSKFNDVFDIKRTKEKDGMLSLKVPLDYEKEKTHKFIVIVEEHTVSRTPDNKGLLKRTEVIIDVTDVDEPPIFNQTEYTFSVFEGPFKNPVIGAVSAKDPDSASYKIRYTIEDANCPVDVDPVNGYLSLKRTLDREQESLYTFQVTAHEDVLNGLKSSTMVSLKVLDINDNAPELTNGSYVYVCENDKPNTIIGTIGASDKDENSGRFRFTLARKSSNFSLYDNQDNTATIVLKQGGFSTENSEEYVLEIEIADGGTPEQKSVNLLQIKVCTCQSGRRVEYCMSYARTGMSVSALLAILLCIITILVIVILIVLRRRYQKEVLVTKASGEIHEQLVRYDEEGGGEMDTNGYDVSILSSACHDSSFRPSVGPALYAMVKKPPACKGDMAMMIEVKKDEADRDRDGIPYDTLHIYGYEGTESLAGSLSSLDSSSSGSNLDYDFIHEWGPRFRTLAQLYGVDGSDSDSSY
The following text describes a protein:
Function:
Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).
Subcellular Localization:
Nucleus.
Sequence:
MADEGSSRAELIEASPAPALDLPSPPRKPRGRPLGSKNKPKPPVVVTRESEAAMRPVVLELGAGCEVAAAVAAFARRRRVGVSVLCGRGTVAAVTLRLPTSPPAAVKLHGRFEVLSLSGTVLPSAAGEGAAPPPPFSVSLAGAGGQVIGGTLAGEMTTADGLVVVAATFGSAEVHRLPADEDDEATGSRGGEERRHPQQQPPQTVAATSAVDVGLLGYGGGVGVAGGASGGQVGRHQQQQQQAEMVLWAQSPGSVGPAHPATSRY
The following text describes a protein:
Function:
Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
Miscellaneous:
MISCELLANEOUS: Present with 1720 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MDFVVDYQTYAMADTATPELPEPEPRLNLTSDAQSQPTGKLDLQFKLPDLQRYSNNNATLPVDNDGAGSKDLHKKMTHYAMSSIDKIQLSNPSKQLGQNSQDEKLSQQESQNFTNYEPKNLDLSKLVSPSSGSNKNTTNLVLSNKLSKILNNYTLINYQATVQLRKSLKVLEENKERLSLDEQKLMNPEYVGTLARRALRTDLESQLLKEHITVLEEFKPIIRRIKRLSSSVEKIQRTSEKLLSNETNEVPTNNVVLQEIDQYRLKAEQLKLKKKILLSIRDRFTLNQVEDDVITNGTIDNIFFEVVKKVINIKDESSFLLTLPNLNAGNALIMGVNEILEKTNKKIFNYLIDFLYSFESSSNLLNDHGTTEQESLNIFRKSLVFLSSDLELFNELLKRVTTLRSKSILDEFLSQFDMNSTTSKPIILSAHDPIRYIGDVLASVHSIIANEADFVKSLFDFQDEDLKDTPISILQQNKTFLKGIDNKLLNDIIQSLSNSCRIRIEQIVRFEENPIINFEIVRLLKLYRVMFERKGIQDDSSIINNLKSLEDISKNRIIGYYEDYMKQTVMAETKNSSDDLLPPEWLSEYMNKLVELFEIYEKTHAAEDEESEDNKLLSSKNLQTIVEQPIKDVLLKQLQTSFPLAKKNEKEKASLLTIEINCFDLIKSRLQPFEGLFAQDDDSRKITIWVCDKLKEYTKQMLTLQIKFLFENTGLDLYSNLVNMIFPVDSVKDELDYDMYLALRDNSLMELDMVRKNVHDKLNYYLPQALTDVQGNLLFKLTSPMIADEICDECFKKLSLFYNIFRKLLIHLYPNKKDQVFEILNFSTDEFDMLIGIDH
The following text describes a protein:
Function:
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular Localization:
Endomembrane system; Single-pass membrane protein.
Sequence:
MNISVNPYLMAVVFVVFVLLLWAMNVWVYRPLLAFMDNRQAEIKDSLAKIKTDNAQSVEIGHQIEALLKEAAEKRREIIAEAIQKATESYDAVIKQKENELNQEFEAFAKQLQNEKQALKEQLQAQMPVFEDELNKRVAMGLGS
The following text describes a protein:
Function:
A global transcription factor. Activates transcription of the 9 following operons; yjjQ-bglJ, yjjP, acrEF, ybdO, yjcRQP, casABCDE12, rhsD-ybbC, fepE and gltF, in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operons; uxaCA, sdaCB and btsT. H-NS repression of the bgl operon, leading to the ability to metabolize some beta-glucosides. It also directly activates the bgl operon. Activation is H-NS and BglJ-RcsB independent.
Sequence:
MPEVQTDHPETAELSKPQLRMVDLNLLTVFDAVMQEQNITRAAHVLGMSQPAVSNAVARLKVMFNDELFVRYGRGIQPTARAFQLFGSVRQALQLVQNELPGSGFEPASSERVFHLCVCSPLDSILTSQIYNHIEQIAPNIHVMFKSSLNQNTEHQLRYQETEFVISYEDFHRPEFTSVPLFKDEMVLVASKNHPTIKGPLLKHDVYNEQHAAVSLDRFASFSQPWYDTVDKQASIAYQGMAMMSVLSVVSQTHLVAIAPRWLAEEFAESLELQVLPLPLKQNSRTCYLSWHEAAGRDKGHQWMEEQLVSICKR
The following text describes a protein:
Function:
Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.
Sequence:
MATATTTVLEKPNIGVYTNPKHDLWIAESTPTLEDVKSGNGLKPGEVTIEVRSTGICGSDVHFWHAGCIGPMIVEGDHILGHESAGQVIAVAPDVTSLKPGDRVAIEPNIPCHACEPCLTGRYNGCLNVAFLSTPPVDGLLRRYVNHPAVWCHKIGDMSFEDGALLEPLSVSLAAIERSGLRLGDPCLITGAGPIGLITLLSAKAAGATPLVITDIDEGRLQFAKSLVPEVRTYKVQFGLSAEEQANAIINVFNDGQGSGPDALRPRLALECTGVESSVASAIWSVKFGGKVFVIGVGKNEMTIPFMRLSTQEIDLQYQYRYCNTWPRAIRLVQNGVINLKRLVTHRFALEDALKAFETAANPKTGAIKVQIMSSEEDVKAASATQ
The following text describes a protein:
Function:
PUMPS are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. This leads to a decrease in the efficiency of oxidative phosphorylation and an increase in heat production. May be involved in protecting plant cells against oxidative stress damage (By similarity). Recombinant PUMP4, reconstituted into liposomes, transports a wide range of dicarboxylic acids including malate, oxaloacetate and succinate as well as phosphate, sulfate and thiosulfate. However, it is unknown if these transports are of any biological significance in vivo.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MGVKSFVEGGIASVIAGCSTHPLDLIKVRLQLHGEAPSTTTVTLLRPALAFPNSSPAAFLETTSSVPKVGPISLGINIVKSEGAAALFSGVSATLLRQTLYSTTRMGLYEVLKNKWTDPESGKLNLSRKIGAGLVAGGIGAAVGNPADVAMVRMQADGRLPLAQRRNYAGVGDAIRSMVKGEGVTSLWRGSALTINRAMIVTAAQLASYDQFKEGILENGVMNDGLGTHVVASFAAGFVASVASNPVDVIKTRVMNMKVGAYDGAWDCAVKTVKAEGAMALYKGFVPTVCRQGPFTVVLFVTLEQVRKLLRDF
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Sequence:
MAGGRGFVLTSHKVAMCMLLQAYASPSSASPPFCVLPSSARHRLALFLLDQTRVTDGFLEPTFEELGKELKDDLSDVGGVLFEQLGSRLPLLCTPEELFQFFQGLKELLAPVSYSAESGRGEDETLLIQPNSLLGQFLRRCILAFNVLSFEGSGRLVVELNAYRWLESSDPRGIFVDKDDMIEGEFDDEYEYEEDIDDVNMDGIHDLEFRFRGTAAGRRGMQGRQQSGGRNGASAFPVPNAAISGDSGVKTRSLRTVEQVEGFLKEQAGLLEKGVGQIPKEGLDSNLTQLEKLAPDMMKVHYLRYLNHLQQSDYPATMDDLHRYFDYSAGMGGMSVGGASCDSSVGRFQAGLLSLGSMHAHFGHVDQAMQALNEAVRIAQQYNDDACLAHALAALCHLLFDVGAANEAYAKGESAGLRDVGAGPSLGIQQQLLLLLRRCLRRSLELKLSQLVAFSRLALAKFYLKHVRRFSSLGGLENGGELGTSPLEVCKTLRLSPYLLGDSISNGISPHVAISGTTNQQRGNGMNINQPLTAPGTMAGGAWTSLTGRLGRTSDAVVKLAGTSHLLRAASWELYGSVPLVRVSALIHATCYADVASSDDVLLSYIKLAQHQAAFKGYAAAQSAFEVAAKRFPAAANSLVRTAQLQLVHDHALYRGELKLAQVACGELAASASPVFGVDMERKTEATIRHIRTLLVAGHLDEAAAVARLLFSQCYKASMQLESVLVLLLLAEIHKTADSAVTGLPYALAGLTLCRVFNLDYLQASAKETLAELWLGLGVGHAPRALALLQECLPMVLGHGGLELRARTNLALARCFLSDPAFSAESQLAEVLDLLQQAAEEFELLEDYALAGEAFYLQALAYNKWGSVEERNSAAKAFQRCMQALNVAQASENAVLPL