The following text describes a protein:
Function:
Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Required for the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Plays a central role in X-chromosome recognition and in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto the X chromosomes in hermaphrodites, which leads to a reduction of X-linked gene transcription and an equalization of X-linked gene expression between the sexes. May confer protection against toxicity induced by heavy metals such as arsenite.
Subcellular Localization:
Chromosome. Note=Localizes specifically to X chromosomes in hermaphrodite (XX) embryos.
Sequence:
MSDESELGNQSEMESFNESDSPDEADPDVVIIHDIVHLRASTTGDYSQSEIGKLPEQNTFFLPGRVKRNISSNDSDVIIDEDEIPDGAIRITSDTHFIGSSRGTSELGDFEMDEQEFLNITIEENGNEQELEEHLRNAYRHEEEECFEEEDDIIELPPLPVKPAVKKPRRKLPKHLSIESGSTAKTSKLVAEVVHDHPRPVNYRMKPAVTDDGKVVEQKRTRVTRNIMSHTIPQYHLEGEETEFGRVKESTLSKTIEQYLQAGKLVSPKCDQFREQIVATAVEYDGSVKMLQFENALKKHSGKQKRLKYQTGWWKASKSHYERAVNGYVAMPKTPVLSISDDPVLYKHHSLFPKNQSSELEKINVQLRIRLNSKRQNNDVIPDSSYFVREFLMQKHSISLRMNRSSDLPELFVPPTLECGYFPQDAVTVQQQEHYLMMRFEEAQDEYHNITYRSIAPPVEFQVGTISAKELHKFHRIGRHIHGFFVVWENKFPEYDESGICCPRKRYLVDMFNLICFPLYTEYEQWESRLRVAFDKTIVYNLHLSEILRCNRPVFDFLSKNKSMLQPITLKEIVYLIEQSNMDAKSFAVKFGLRTFYDHGRATSNKDYLSAFLIITGGAKVVTEEIDSERLRVFNSDYMESGVLTSSGDVYTFEFDKIPNNYQISIGCNADGVAEMEQEDVRHELSECSSRITRIIGDSKKPEKIIARPLVKTNQNDGMKFFTRKDLLNYRIKLYDPSYVVPRAKKQIVNEPAKKKPGRKSKTRYDAAMQQNNFEIEGVPSDVDSEFEGYLSDSENVFQKPSKLMRSTSSDSVFIDYQYREKMFLDVSWFHQQKMIDRSLPPLKKRKRKMNRIYHKHSVRYTMLQANGCAFTEMYRCYDKILPCGTKEIARTKNAIRFPHRFRTYNIPQVYGPGDKQLITEVFGVVKDVITRATGFESASIRTANDIAQAVYDANIARRELLENLEPSDNGILPSPAYLAIEMLSHQKMSGRLCLESARKDVQNNVDKMYNDYMDLDPLDKELHFEISQSIRQSKLNESLEEYERNRERQLAKTLKTVPMDKRSQAALARREEKRRESRRKLADKYAEQRRMMASTRRLEKRTTQKQVDPETIQRLRREDEVRKRKRFEEEDRRGMIRRREERVALQEKVDRMLEEGLRLEKVREAERIRQQQEEERIEMETILISRRVREEEEEKMRLERLRKAEREREQERLKREEEEERKRLEQLREAEKLKAEIEKENERKLQEERTRKALELERKIEEIKRVSTLKDMFGPLPIAKENEQTEKDFQILLDDHELTLLTISRDPLNEKYQEARTEFERLDIKSMLLRKAEKLIDVLTIHYDVPIEQTCRYFTSSIESNENRMAVNEQLNKLFENMANCFTFNIQDGENGLQSKRKWDFQFKKCAVFDGVSQSTVNFIEEKMRENTKKKHLATPKTVISIDTSLLKQSLLRSHARFDPDISLYAQNHTANSIGDVTLKMSNYSLDFATQSIHDKELAEKATPKKGPTVRRHIKNLFGSEKVIVRRSLAAGKPASLNSEDSDSEDSREGSPVAEFLPTNPVCSFWKLVVKIENSTTDKEKTELCEDLDKLILRKDDLFSKSLKWMFPLLATFYVLLSNAVLNENEEIISDKNQTGVTKDEILKSTINDLMIIAAYFEEGSRERSNLRKMISMNGFSVVFNRVILFAKKTCTLAKELESNSRSLSGYVIEDLFESLLAEIERTMRQELGSSVRKTGKLERDFEEIVKLIQNEKKLALSHKSHKNDENRRFRLNTVVKWYDAIICHCKEELTQAIVDAFPLNAITKNKETSHVAMENGDDEAMLSDTSDNQMSTTDYQMPKNICRNSEIFPEDAFAKAYAVVRIPSKKERAQMLSVYRKKNAQSGCVENKGLSRMPKFEEPFVDSVWRTIEKRINNMTHSEEKQIKRFIPVSRSHKLNEKVKFYAMVMIQERDSRDTRLFNSKFQDDNLWHCYSKSSLNHEKMESRILQHIEHTVLSKSNFNQMKWSVQCVNGNKKDAIHYFTDLYKYRSESEFRSALSCGKLKFNFKVYTHLWFMGNLLPTSYNPDSHDDKLFVPCSGCTSGDVIIIHKCTCAYHNDTFSDKFIYANTSLPVGIDKVTRLVGRFVCEHGPSSFLILEHCSANVDANIPFESENVEFSAELRIVKRKTMHSQLVKTFAEEHTHLRDASRHRAISTVTLDSSGSGRSTRCEIFEDSPSEDENDENQLDTTRIGRKIDPIIVDSDKAYLIAEGERMALRIKRLLDPELQKFRSKNFVSRSKSVDAPKTSKQKTVIRRSQSVCDLNDVNEYAQKKVRNTKDSFATLFRDHEYSTRRTYEEQLNNELLDVVTTFGGASNVSADKKYNILASILAFEKEVQLVNDKNGELFKTVSNLVQRNSLQHVKGVILAEDNQTLRSTDNTSEVFPESKAVNEYLKFEIYKRKMMVNAKLMADTVKDLKLKHAEYRPFAKLIATYDSIFKFNVYLFEHFLNCISKHVFNPYAIYCEETRPTGTELSKFQLTLKLIETSMPTVLSMLFNTEPLRRQLSELSEIHKKVRSEDLACTIASLCRYAIERIRIPQTADKRLCDFSWLNSAEDHRETVSFIRLTLEHTLPDMKTENEQTRFVEFLKEAEGFHFSYKFVEAQCKTFVRNHGDSKQAFFTAFYNQNEAFYGSLQKFMSNGTIDPKMKLYYQHQAFLRLHNIVKKRSHIITSDDYHRSSDVCKAMLLSEIVSNPKIAQEAYISGSVLDRMYTSLCKIKAKMPLISPSYIGTSLTCFEDELLFSAVREAKVHTDTRVVFRSKSCMRPNEKAGDANFKTCKVTLLVNLETALLSMVFKSRDQSEIDKDDRLDIDILDEEVIKPIIDWNRIFETFIQPTYNTLFSRMEKRERVSILPENPLGRLENYAFTNPNQDKDCQAVLEYIDVASDTDAEESIEDPLDIVEMTLKRALPRSMSPSSKRRRMR