lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF).
Subcellular Localization:
Cell membrane. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus. Membrane, clathrin-coated pit. Nucleus.
Sequence:
MSGQSLTDRITAAQHSVTGSAVAKAVCKASTHEMMGPKQKHLDYLIQCTNELNMSIPQLADTLLERTANSSWVVVFKALITAHHLMMYGNERFMQYLASRNNLFNLSNFLDKSVIQGYDMSTFIRRYSRYLNEKALSYRLVAVDFTKMKRGSDGVMRTMGTDKLLKTLPVIQNQLDVLLDFDAHPNELTNGVISSAFMHLFKDSIRLFAAYNEGIINLLEKYFDMKKNQCKEGLESYKKFLGRMAKLSEFLKVAEQVGIDQADIPDLTQAPSSLFEALEQHMASLEGRKTKELLAAYRISHLPTAMSTLASTGKAISQVVEKQKKYPLDEDLVKLHTRKEKWLKEIPVVSDSATTSESPSLLDPPNVTTSSVINLFGPSLPPSTSLASTSDDLFGLESAFILTPQSATTTAMGTLPSQTWGADFHLSPLPSSAPLEVPVDFDSVFGSKSLDSEYEYGATNGRSCHSGTGSGLDEIPAPLSALTAQEHHEIPGSQQRGTVLVNDLDSSLANLMGNLDFGMSPQKSDIQWNQPSEKKMTGGMNWQVKTSTATTWSPATISPVPHMVPVPVSHPVNPHPLPVYGMVQTPLGAVPLVAPQPLIYAQPGLRTTNPFAPVSGPQEDVDAFMKQPGNESIDTVLKKLDEQYQKYKFMELNLTQKKRRLKNQIPDIKQTLHILKYMQKKKETTKPLETRFLLADNLYCKAFIPPTDKVCLWLGANVMLEYDINEAQGSLGEESLCCHQQSGILLRKT
The following text describes a protein:
Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MQPFIVPVQITLQGGRRRQGRSGCSASERWKKKDRGDGGSAADVPRKPPSSAGEDRAILLGFVMMGFSVLMFFLLGVTILKPFLLSTQREEANCTIMDTRVKDDWLDCSFTCGVDCRGQGKYPCLQVSVNLSHSGQKAFLHYNEEAVQINPECFYTPKCHRDRNDLLSSALDIKEFFDHKNGTPFSCFYSPDGKPEDVVLIRKYDHTVVFHCVFWPSLTLLGGALIVGMVKLTQHLSVLCDEYAHVVREDAGKAASQKELRPHRLWRKGREKGRKPGLSGGWPS
The following text describes a protein:
Function:
Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X where X is Ser, Ala, Met, Cys, or Gln. Required for the membrane localization of proteins such as a-factor, Ras proteins and other membrane proteins containing the C-terminal CAAX motif. The beta subunit is responsible for isoprenoid and peptide-binding.
Miscellaneous:
MISCELLANEOUS: Present with 3910 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MRQRVGRSIARAKFINTALLGRKRPVMERVVDIAHVDSSKAIQPLMKELETDTTEARYKVLQSVLEIYDDEKNIEPALTKEFHKMYLDVAFEISLPPQMTALDASQPWMLYWIANSLKVMDRDWLSDDTKRKIVDKLFTISPSGGPFGGGPGQLSHLASTYAAINALSLCDNIDGCWDRIDRKGIYQWLISLKEPNGGFKTCLEVGEVDTRGIYCALSIATLLNILTEELTEGVLNYLKNCQNYEGGFGSCPHVDEAHGGYTFCATASLAILRSMDQINVEKLLEWSSARQLQEERGFCGRSNKLVDGCYSFWVGGSAAILEAFGYGQCFNKHALRDYILYCCQEKEQPGLRDKPGAHSDFYHTNYCLLGLAVAESSYSCTPNDSPHNIKCTPDRLIGSSKLTDVNPVYGLPIENVRKIIHYFKSNLSSPS
The following text describes a protein:
Function:
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Sequence:
MIFQTTSEDTLTKARTGILNLNGIELKTPVFMPVGTRGVVKTLSADDLEELEYSLILGNTYHLYLRPGTSVLDRFGGLKKFSTWKKALLTDSGGYQVFSLNSLFKYEQDGVRFQSHIDGSRHYFTPNSVIDIQRSIGSDIMMVLDDCAPFDSGPERLKQSLDRTHRWAEMSVQYWEKNKNSQHLFGIFQGGIDLDFRLESLNTITSLPFDGIAIGGLSVGEPRKDFIRILDGISAHTDRNRPLYLMGVGTVPDILDGVKNGVDMFDCVLPTRNARNGQVFTTLGKINLRNEKWKSSDTPMDPNCTCKVCKRYSIGYIRHLHHVGEITAFSLSTYHNLHFMKNFLTEIQNSIQKGEFLEIYAKWKNLYEKPEFSG
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MDGERRVHPDCINASNPYHECVEYCFKKIAEAKAKLEKQGLVEAVSGQSRESLADKRIEEASSEEEEEDEEDNQEPQVDVTQLTGRKKKLYELKVKMNEARKSNQTDVGSEKKKMEAPTEPKGISKQKWVEARQKKIGKILDANGLDMSKAYMLDTQEAAETKYKKWEKEPTPSGWDVFNQKTLYNAYKKRTKNIQVDIEEYNRMRAADPEFYREASSLQYGKAPKISKDKIDKMAKELHDREEKRQEFSRRRKFREEKDIDSINDRNEHFNKKIERAFGKYTLEIKNNLERGTALPD
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion.
Sequence:
MAEIELKTAPADYRFPTTNQSRHCFTRYVEFHRCVAAKGDDASECQKFAQFYRSLCPGEWVDRWNEQRENGIFPGPL
The following text describes a protein:
Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSTKSKDQHARVSYLYQASQLLFRNVQEPTLSRHYISTAKDVSQKSVMRIHPDIKRTICKGCNSLLVPGKSCSIRFEEPSRKNPSIDRVLWICKKCAFKKRFSDKSC
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MNCLYLIRGAAGNTLAQPQFSNSPIWMFDNEYRPSLAENLLKLNRLITTINNINSNIGENSSNIDPTTTTTTSTADNLEIKNEANDDIVGNENVNNNNHNNPNSNNIDPSPTITPTSINSQQENNNNNNNNNNNQNQLFIKEFLNDFTTRVLWFTYRQGFPCIDDTMYDNDCGWGCMLRSGQMLLSNVLLHNILGDEWKRSSSATHPDIISMFLDKPSAPFSIHNIAMEGQNLGKNIGEWFAPSIISQTIKILVSRNYDQCNISVFISEDGSLYIDQLLNISSKKKKTSSTEQQQKQQQIESSTDNGDDKINDEKHNENVDKNNIDDNNNNNNNNNNNNNNNNNNNNNIINDSSNVNEKQDKIDDESKDEISENNNKDNDETWEPLLILIPMRLGLDGLNSIYHSSLLEIFKFPQNLGVVGGKPRASLYFIAAQDDNLFYLDPHTVQNHIEVENGSKFPLNTFFCSTTKRTHVSEVDPSLVVAFFCKTKDDFNDFVERSKKMTSQMENPIFSIFDNEPDYDSSRDYEYEEIDETGGETSDDIDIEADYHMM
The following text describes a protein:
Function:
Pseudokinases lacking protein kinase activity and unable to bind ATP-analogs. Negative regulator of pathogen-associated molecular patterns- (PAMP-) triggered immunity by limiting BAK1-receptor complex formation in the absence of ligands.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MKEIGSKPRKLLPLCFIIFLCFCSSVMAADEDDIRCLRGLKASLTDPQNALKSWNFDNTTLGFLCNFVGVSCWNNQENRVINLELRDMGLSGKIPDSLQYCASLQKLDLSSNRLSGNIPTELCNWLPFLVSLDLSNNELNGEIPPDLAKCSFVNSLVLSDNRLSGQIPVQFSALGRLGRFSVANNDLSGRIPVFFSSPSYSSDDFSGNKGLCGRPLSSSCGGLSKKNLGIIIAAGVFGAAASMLLAFGIWWYYHLKWTRRRRSGLTEVGVSGLAQRLRSHKLTQVSLFQKPLVKVKLGDLMAATNNFNSENIIVSTRTGTTYKALLPDGSALAVKHLSTCKLGEREFRYEMNQLWELRHSNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKGDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEISKFVEIALNCVSSRPKERWSMFQAYQSLKAIAEKQGYSFSEQDDDFPLIFDTQENEKV
The following text describes a protein:
Function:
Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Recognizes spermine, but not spermidine.
Miscellaneous:
MISCELLANEOUS: Present with 2760 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNRQESINSFNSDETSSLSDVESQQPQQYIPSESGSKSNMAPNQLKLTRTETVKSLQDMGVSSKAPVPDVNAPQSSKNKIFPEEYTLETPTGLVPVATLHSIGRTSTAISRTRTRQIDGASSPSSNEDALESDNNEKGKEGDSSGANDEAPDLDPEIEFVTFVTGDPENPHNWPAWIRWSYTVLLSILVICVAYGSACISGGLGTVEKKYHVGMEAAILSVSLMVIGFSLGPLIWSPVSDLYGRRVAYFVSMGLYVIFNIPCALAPNLGSLLACRFLCGVWSSSGLCLVGGSIADMFPSETRGKAIAFFAFAPYVGPVVGPLVNGFISVSTGRMDLIFWVNMAFAGVMWIISSAIPETYAPVILKRKAARLRKETGNPKIMTEQEAQGVSMGEMMRACLLRPLYFSVTEPVLVATCFYVCLIYSLLYAFFFAFPVIFGELYGYKDNLVGLMFIPIVIGALWALATTFYCENKYLQIVKQRKPTPEDRLLGAKIGAPFAAIALWILGATAYKHIIWVGPASAGLAFGFGMVLIYYSLNNYIIDCYVQYASSALATKVFLRSAGGAAFPLFTIQMYHKLNLHWGSWLLAFISTAMIALPFAFSYWGKGLRHKLSKKDYSIDSIE
The following text describes a protein:
Function:
Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into an unidentified sesquiterpene as a major product, as well as beta-maaliene, aristolene, calarene and 2 additional unidentified sesquiterpene as minor products. Is also able to convert geranyl diphosphate (GPP) into a mixture of monoterpenes including (Z)-beta-ocimene, (E)-beta-ocimene, allo-ocimene, linalool and beta-myrcene.
Domain:
Contains several highly conserved motifs that are important for catalytic activity including the aspartate-rich 'DDxx(x)D/E' motif and the 'NDxxSxxxD/E' motif, both of which are involved in complexing metal ions to coordinate the binding of the isoprenyl diphosphate substrate in the active site.
Sequence:
METINLEKPLYSLKKFYFPSEWSYPINKNYKHIKDTYNEGVSCGIFEASNEKHFAYANGVLNCVTWFYPKYDYEQCMVAASIMLWIFVLDDFLERDHMTDEKQQYCVKKYEDILIFGKDSSYISNIEYNDLTPLDKYSLILRKRLLNPTIHRIESFNIFIHYLREWFFSIIPLKKSKGNNHDSVPIEVYQFIRTINIGLFFVVGVNSVAVRTNVHGSFWLNPIWNRMVRSASRQIIIFNDCVSYAKELNHDCAGENCLYILQKKLNLPFEKVYSELIAEAKQCIFDIQNDEKLLIKSLSHISEEEMNGVIYLVEQLHEIICGNRDWALMTPRYIHKDSPFIETNGIDSLFVPYETILDPNLY
The following text describes a protein:
Function:
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner; Fibronectin type-II domain mediates collagen-binding; Ricin B-type lectin domain contacts with the second C-type lectin domain.
Sequence:
MGPGRPAPAPWPRHLLRCVLLLGCLHLGRPGAPGDAALPEPNVFLIFSHGLQGCLEAQGGQVRVTPACNTSLPAQRWKWVSRNRLFNLGTMQCLGTGWPGTNTTASLGMYECDREALNLRWHCRTLGDQLSLLLGARTSNISKPGTLERGDQTRSGQWRIYGSEEDLCALPYHEVYTIQGNSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWDKDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITEIHEQTYINGLLTGYSSTLWIGLNDLDTSGGWQWSDNSPLKYLNWESDQPDNPSEENCGVIRTESSGGWQNRDCSIALPYVCKKKPNATAEPTPPDRWANVKVECEPSWQPFQGHCYRLQAEKRSWQESKKACLRGGGDLVSIHSMAELEFITKQIKQEVEELWIGLNDLKLQMNFEWSDGSLVSFTHWHPFEPNNFRDSLEDCVTIWGPEGRWNDSPCNQSLPSICKKAGQLSQGAAEEDHGCRKGWTWHSPSCYWLGEDQVTYSEARRLCTDHGSQLVTITNRFEQAFVSSLIYNWEGEYFWTALQDLNSTGSFFWLSGDEVMYTHWNRDQPGYSRGGCVALATGSAMGLWEVKNCTSFRARYICRQSLGTPVTPELPGPDPTPSLTGSCPQGWASDTKLRYCYKVFSSERLQDKKSWVQAQGACQELGAQLLSLASYEEEHFVANMLNKIFGESEPEIHEQHWFWIGLNRRDPRGGQSWRWSDGVGFSYHNFDRSRHDDDDIRGCAVLDLASLQWVAMQCDTQLDWICKIPRGTDVREPDDSPQGRREWLRFQEAEYKFFEHHSTWAQAQRICTWFQAELTSVHSQAELDFLSHNLQKFSRAQEQHWWIGLHTSESDGRFRWTDGSIINFISWAPGKPRPVGKDKKCVYMTASREDWGDQRCLTALPYICKRSNVTKETQPPDLPTTALGGCPSDWIQFLNKCFQVQGQEPQSRVKWSEAQFSCEQQEAQLVTITNPLEQAFITASLPNVTFDLWIGLHASQRDFQWVEQEPLMYANWAPGEPSGPSPAPSGNKPTSCAVVLHSPSAHFTGRWDDRSCTEETHGFICQKGTDPSLSPSPAALPPAPGTELSYLNGTFRLLQKPLRWHDALLLCESRNASLAYVPDPYTQAFLTQAARGLRTPLWIGLAGEEGSRRYSWVSEEPLNYVGWQDGEPQQPGGCTYVDVDGAWRTTSCDTKLQGAVCGVSSGPPPPRRISYHGSCPQGLADSAWIPFREHCYSFHMELLLGHKEARQRCQRAGGAVLSILDEMENVFVWEHLQSYEGQSRGAWLGMNFNPKGGTLVWQDNTAVNYSNWGPPGLGPSMLSHNSCYWIQSNSGLWRPGACTNITMGVVCKLPRAEQSSFSPSALPENPAALVVVLMAVLLLLALLTAALILYRRRQSIERGAFEGARYSRSSSSPTEATEKNILVSDMEMNEQQE
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex.
Subcellular Localization:
Nucleus.
Sequence:
MAATVNLELDPIFLKALGFLHSKSKDSAEKLKALLDESLARGIDSSYRPSQKDVEPPKISSTKNISIKQEPKISSSLPSGNNNGKVLTTEKVKKEAEKRPADKMKSDITEGVDIPKKPRLEKPETQSSPITVQTSKDLAMADLSSFEETSADDFAMEMGLACVVCRQMMVASGNQLVECQECHNLYHRDCHKPQVTDKEANDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPAVVSVTPAVKDPLVKKPETKLKQETTFLAFKRTEVKTSTVISGNSSSASVSSSVTSGLTGWAAFAAKTSSAGPSTAKLSSTTQNSTGKPATSSANQKPVGLTGLATSSKGGIGSKIGSNNSTTPTVPLKPPPPLTLGKTGLSRSVSCDNVSKVGLPSPSSLVPGNSSQLSGNGNTGTSGPSGSTTSKTTSESSSSPSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK
The following text describes a protein:
Function:
Key microbial factor involved in regulation of early and late events in tuberculosis infection, and in host-pathogen interactions. Modulates host immunity during early infection. Slows mycobacterial growth during chronic infection in host and during a variety of stress conditions in vitro. Regulates the expression of a large subset of tRNA genes as a means to facilitate adaptation to changing growth environments. In vitro, directs the inhibition of transcription and translation processes in a phosphorylation-dependent manner. Phosphorylates the transcriptional regulator VirS, thereby increasing the affinity of VirS for the mycobacterial monooxygenase (mymA) promoter. In vitro, can also phosphorylate the mycobacterial monooxygenase operon products Rv3083 (MymA), Rv3084 (LipR), Rv3085 and Rv3088.
Subcellular Localization:
Cytoplasm. Cell membrane. Secreted, cell wall. Note=Probably attached to the cell membrane through interactions mediated by its C-terminal region. May be secreted during infection.
Domain:
The C-terminal region exerts intrasteric control that autoregulates kinase activity.
Sequence:
MTDVDPHATRRDLVPNIPAELLEAGFDNVEEIGRGGFGVVYRCVQPSLDRAVAVKVLSTDLDRDNLERFLREQRAMGRLSGHPHIVTVLQVGVLAGGRPFIVMPYHAKNSLETLIRRHGPLDWRETLSIGVKLAGALEAAHRVGTLHRDVKPGNILLTDYGEPQLTDFGIARIAGGFETATGVIAGSPAFTAPEVLEGASPTPASDVYSLGATLFCALTGHAAYERRSGERVIAQFLRITSQPIPDLRKQGLPADVAAAIERAMARHPADRPATAADVGEELRDVQRRNGVSVDEMPLPVELGVERRRSPEAHAAHRHTGGGTPTVPTPPTPATKYRPSVPTGSLVTRSRLTDILRAGGRRRLILIHAPSGFGKSTLAAQWREELSRDGAAVAWLTIDNDDNNEVWFLSHLLESIRRVRPTLAESLGHVLEEHGDDAGRYVLTSLIDEIHENDDRIAVVIDDWHRVSDSRTQAALGFLLDNGCHHLQLIVTSWSRAGLPVGRLRIGDELAEIDSAALRFDTDEAAALLNDAGGLRLPRADVQALTTSTDGWAAALRLAALSLRGGGDATQLLRGLSGASDVIHEFLSENVLDTLEPELREFLLVASVTERTCGGLASALAGITNGRAMLEEAEHRGLFLQRTEDDPNWFRFHQMFADFLHRRLERGGSHRVAELHRRASAWFAENGYLHEAVDHALAAGDPARAVDLVEQDETNLPEQSKMTTLLAIVQKLPTSMVVSRARLQLAIAWANILLQRPAPATGALNRFETALGRAELPEATQADLRAEADVLRAVAEVFADRVERVDDLLAEAMSRPDTLPPRVPGTAGNTAALAAICRFEFAEVYPLLDWAAPYQEMMGPFGTVYAQCLRGMAARNRLDIVAALQNFRTAFEVGTAVGAHSHAARLAGSLLAELLYETGDLAGAGRLMDESYLLGSEGGAVDYLAARYVIGARVKAAQGDHEGAADRLSTGGDTAVQLGLPRLAARINNERIRLGIALPAAVAADLLAPRTIPRDNGIATMTAELDEDSAVRLLSAGDSADRDQACQRAGALAAAIDGTRRPLAALQAQILHIETLAATGRESDARNELAPVATKCAELGLSRLLVDAGLA
The following text describes a protein:
Function:
Component of the cytoplasmic dynein which acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.
Miscellaneous:
MISCELLANEOUS: Present with 1170 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Concentrates at motile dots in the cytoplasm corresponding to the plus ends of cytoplasmic microtubules.
Sequence:
MDNCNAWDKLLSQNESTINSTETATITAIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDRDMKDHIEMVKRSEILIPKGCDSIGLIKTVDERFEPTEVKEQHFLARYMDFIPTIDKIREDRKTTSGIDLDKLYPLEVFKVNIQEELGKMFAKYRENSRI
The following text describes a protein:
Function:
Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAGEADGPFKGLLVPILLPEKCYDQLFVQWDLLHVPCLKILLSKGLGLGIVAGSLLVKLPQVFKLLGAKSAEGLSLQSVMLELVALTGTVVYSITNNFPFSSWGEALFLTLQTVAICFLVMHYRGETVKGVAFLACYAMVLLALLSPLTPLAVVTLLQASNVPAVVVGKLLQAATNYRNGHTGQLSAITVFMLFGGSLARIFTSVQETGDPLMAGVFVVSSLCNGLIAAQVLFYWNAKAPHKQKKEQ
The following text describes a protein:
Function:
Involved in the export and assembly of LpfA fimbrial subunits across the outer membrane.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MTWTHLPLGNKTSRFTQSALALMIAGTLPAYAGTFNPRFLEDVPGIDQHVDLSMYESNKAEHLPGKYRVSVVVNEKKMESRTLEFKAATEAQRAKMGESLVPCLSRVQLEDMGVRIDSFPALKMAPPEACVAFDDIIPQAASHFDFADQTLIMSFPQAAMKQTARGTVPESQWDEGVNALLVDYNFSGSNASYDAHDSETSYNSDSYYLNLRSGMNLGAWRLRNYSTWTRNDGNNTWDNIGTSLSRAIVPLKSQLTLGDTSTAGDIFDSVQMRGVQLTSDEEMLPDSQRGFAPVIRGIAKSNAEVTVEQNNYVIYRTFVQPGAFEINDLYPTSNSGDLTVTIKESDGSEQKFVQPFSSVALLQREGHLKYSLSAGEYRAGNYNSAEPKFGQLDAMYGLPYGFTVYGGAIFSDDYYSLAGGLGKNFGYIGAISIDVTQAKSKLANEENSEGQSYRFLYSKSFNSGTDFRLLGYKYSTSGYYTFQEATDVRSDADSSYSQYHKRSQIQGNVTQQLGAWGSVYFNVTQQDYWNDEGKQRSLNAGYNGRIGRVNYSVAYTWTKSPEWDESDRLLSFSMSIPLGRVWSNYHLTTDQHGRTNQQLGVSGTALEDHNLNYSVQEGYGSNGVGNSGSVNLDYQGGVGSASLGYNYNRDGQQVNYGLRGGVIAHSEGITLSQPLGESMAIISAPGARGAHVINNGGVEVDWMGNAVVPYLTPYRETEVSLRSDSLNNQVDLDTASVNVVPTRGAIVRARFDTRVGYRVLMNLTQANGKAVPFGATATLLDTTKESSSIVGEDGQLYISGMPEKGALQVNWGKDQAQQCRVAFTLPEQQDNTGVVMANAVCR
The following text describes a protein:
Function:
Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
Sequence:
MEVLSEQQLFFMRKAVALGEKGRIFAPPNPWVGCVIVKNGCVIGEGWHQGIGSPHAEVCAVQDQKCSLEGAEVFVTLEPCCHFGRTPPCVDLLIKSKVAAVYVGLLDPDPRVCKKGVARLQAAGIPVYVGVGSQEAKTSLQPYLYQRERGLPWVVMKTAASLDGQTADRGGSSQWISGELARADVGKLRAESQAIIVGARTVCLDNPRLSARFPHGDLYERQPLRVVVDSRGTVPLESRVFDLSSGSTLFATTQQCPKEYIQKLKDLGVEVWESSSHQVDLKGLLRYLAERGCLQVLVEGGAQLHSAFWQQKLVNAGVIYWGPKFLGDQGQPMLRDLQLSLVTAEHVRITETSLVRDSVKTCFECLEQESVDKKG
The following text describes a protein:
Function:
Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.
Subcellular Localization:
Nucleus. Note=Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.
Domain:
The N-terminal region and all three C3H1-type zinc fingers are necessary to induce transcriptional repression.
Sequence:
MDFENLFSKPPNPALGKTATDSDERIDDEIDTEVEETQEEKIKLECEQIPKKFRHSAISPKSSLHRKSRSKDYDVYSDNDICSQESEDNFAKELQQYIQAREMANAAQPEESTKKEGVKDTPQAAKQKNKNLKAGHKNGKQKKMKRKWPGPGNKGSNALLRNSGSQEEDGKPKEKQQHLSQAFINQHTVERKGKQICKYFLERKCIKGDQCKFDHDAEIEKKKEMCKFYVQGYCTRGENCLYLHNEYPCKFYHTGTKCYQGEYCKFSHAPLTPETQELLAKVLDTEKKSCK
The following text describes a protein:
Function:
Cytokine that plays a critical role in modulating tissue responses during inflammation. Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage. Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB. Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways. Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN. Promotes epithelial cell spreading.
Subcellular Localization:
Secreted.
Sequence:
MAVLQKSMSFSLMGTLAASCLLLIALWAQEANALPVNTRCKLEVSNFQQPYIVNRTFMLAKEASLADNNTDVRLIGEKLFRGVSAKDQCYLMKQVLNFTLEDVLLPQSDRFQPYMQEVVPFLTKLSNQLSSCHISGDDQNIQKNVRRLKETVKKLGESGEIKAIGELDLLFMSLRNACV
The following text describes a protein:
Function:
Beta-ketoacyl-coenzyme A reductase required for the elongation of fatty acids precursors of sphingolipids, triacylglycerols, cuticular waxes and suberin. Responsible for the first reduction step in very long-chain fatty acids (VLCFAs) synthesis. Decreased expression of KCR1 (RNAi) leads to plants with fused vegetative and reproductive organs, and abnormal trichome, epidermal cell and root morphology. Cannot be complemented by KCR2.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MEICTYFKSQPTWLLILFVLGSISIFKFIFTLLRSFYIYFLRPSKNLRRYGSWAIITGPTDGIGKAFAFQLAQKGLNLILVARNPDKLKDVSDSIRSKYSQTQILTVVMDFSGDIDEGVKRIKESIEGLDVGILINNAGMSYPYAKYFHEVDEELINNLIKINVEGTTKVTQAVLPNMLKRKKGAIINMGSGAAALIPSYPFYSVYAGAKTYVDQFTKCLHVEYKKSGIDVQCQVPLYVATKMTKIRRASFLVASPEGYAKAALRFVGYEAQCTPYWPHALMGAVVSALPESVFESFNIKRCLQIRKKGLQKDSMKKE
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MSAKRKSVSFLELDSTGTTTWGSKERPEPPKKRPKQQQGKETVTNPITHTLLSIYYPQTLTLRQYALSKLPKTSRIRRKKIAALGLSSSPPSPSPAPAPASEKPSAAQALEQALGTLLDTTLVCSHDPPSDITSKKEKSDYRWEQWVGFSQGGGGTKGDESHVTLTDGLKGAMYSQSDIVDFVIWLLFSRGSRSASFREKTKTGNGWPGPRHLLCDGFRKGVPPQGRSGDMATTAGHQHQIPGVYAVHQNNCVKVLKEAPWPQFLMLLGKEGERIMLDLLLDCAVFVGVKEGKGNLVQMSGIPVSELQSRRSLATDFAARKDLKGTGGAGGENQELSPSEITFARNRMLYARAALNAKGLVHFGLRHIHVLNRFPCQKPAEGEEASKPDESTTHVMMYIFPRQFGLHNVFTSAVDRQQTAQKFQDYTLREDEIAKKFPKPAEEERPKIKIPKRLRGNTQELVRKLQVLHKRCSYAEMLQYYCPLPKQLEPEQKSQSSQLRISARPSKSSQKNRRNLRPPSTAAVISNSDSQSYSLLDLATPISSISAFCQAVLSKIIPNDFWGSSDSEEGHPQEHNKSVFLKQIDNFIRLRRFESMTLHNLVQGMKLSSISWLASAALSSHKCSQPELNKRKEIYLEFLYYTFDSLLIPLIRSNFYVTESSAHRYRLFFFRHDVWLSVTKPALACLKVKMFEEVKGAEAVKMLEGRKLGFSQVRLLPKGVGSNLRPIMNLRRRVLVRGLGSKGIWGKQKQMLGPSINSVLGPVNSMLKFEKRERPGRLGGGMFAVGDIYQRVKEFRARVMSEVSKKKGKKKFYFVKVDVQAAFDTIPQAAMVELLGKIPGHGVYKESKHVEVSLPLDYEHNPANNDDTNIDNPKYKLKPTKRWHSTTTSFPSITTTTTTTSTTSASISILPQQQDSVATTKKNTLFIPSHSSTKLHTSSALLSLAKEHITQNLVKIGKKYYRQKTGIPQGSVLSSTLCNYFYADLERSQGLAFLGLGTEDDDEGRGISRDGNTLLMRLIDDFLLITTSRSKARRFVEVMHRGFAEYGVTVSANKSLVNFDVCVGGTRVLKLRRGRKTKFPYCGLMIDTRTLEICKSGTGIGTGGVEDNKKDTVVFNGITVEYSRNQGRNFRRKVLNAFKIQSHLLFFDTTHNSFRTTLRNLYSAFLETAIKMWAHARCLSFTQRKPGTALVIDTIKSLIEVAYRLLTSKSRKERYPGYQCSVSKGQVAWLAMVACRQVLVRKQAGYREVIRWLEGEIEKVMRDKKKEKMDTRVLVQVAREVSFC