lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks, nicked Holliday junctions and also intact Holliday junctions with a reduced efficiency. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. Plays a role in DNA repair and in genotoxic stress-induced homologous recombination (HR) in somatic cells. Mediates a subset of meiotic recombination events that are insensitive to crossover interference (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MASHAAVVEIIDDDDDDDDDVAAASTPPALHKRSHAVAAAAPDSPDAFSPSPPDPKRRQLAASTIVLDDTPTPPKRRPPPVAADRSASVVADTPRSFVPCSLRNRAIAGDTPDSVLPSPSFHLDAPDSATPGSDVPCSVGLDDIVPETPGFNSPRLARPPAVPGLTSPMTARKFSGVSCPISLDSDDELDDTVYRESLTRTPSNMAKPEHAIQPCTTSCTDKVENTKSTDKKDYSKSNVGYQTNNSACKNNGTTSYNQPPRANSPCEDSTLKEADPFINNHCPQEENALPIEERKKKQQEEKRLKKEKKAREIEEKKQKRLETKKQKEAMKAELAELKKLEKEKKKWESGKLATKCIVAEIDSSVIESGSVGGHLVQGFHEKGLCFRVTSNSIKGSILWKMQIPNEFTQDQASTSQVPYILFVLQAEEFCDLVSGGTLLDHVQKVRRQYPEFTICYVTNKLMSFIKRREQNQYNKTTSNSNSWKRPPVEEALCKLATHYARVRSRHCTDEAEVTEHIVGLTYSLANCKFRKPLTWLSVHANGSNISKGCVDKDRIKKSAWLKSLVAIPGVSPGQAIAIEKKYPSMRSLLNVYMDDSKSVHEKEHLLEDLRLEGPLGDFKRRLGPACSKKVYTILMAQNGAAEVEVDRRGA
The following text describes a protein:
Function:
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
Sequence:
MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSSVPTEGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDDQWAADPDMYLQSPQSEHTDPHGLYLSCNGGTPAGHRQVPWPEPQSPQALPNGMAAKAQSLGPAEFQGASQRCLQQLGACLQSSPPGTSPPMATGRRGVKVAKHSSEEARPQSCLVGSAIGRPGGEGSPSPKNQESSLKHRLFRSMFLSTPATGAASSSKPVPLPQNKPNSAFRPPQKDSSSNLVAKAQSLPSEQPMGTFSPLTTSDTSSPQKSLRTAPAAGPLPGRSSPAGSPRTRHAQISTSNLYLPQDPTVAKGALGGEDTGIVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSAPPKLKNSYKVSPVLRDFLDRMLVREPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
The following text describes a protein:
Function:
After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MTYPSSSNSPRRVPSVSGEKHYRAKSITRSSVDLDNSESGALFLAPNGLASEADENTEYPPTGTAGAPTRVWSTRRMPLGSRRLAVILFGLVALIMLFGRRDSRDAVVGYVNQKADQVGQAVQNAPWKAKPETGSDHAVGFPVNPPMSTKPAKAPVTGTSADTVRQKPALHPDPTKTTRCDGTGPRPVDHKGNPRPLVQYALMIDAGSTGSRIHVYRFNYCSASPELEDEYFEMLKGGLSNYGTDPAAAADSLRPLLNSALARIPHALRKCTPVAVKATAGLRLLPGKQAEDVIKAVRHMLELEYPFPIADGKNADGSKASKGVEIMDGKDEGVFAWITVNYLLNRIGSSSPDKLETAAVMDLGGGSTQIVFEPSFPSALQGMQPGEHVYQLNAFGTKPYTLYQNSYLGYGLMQARMSINSLAAFTYSLVHPNAVLTGSAHDGAQGSLEWTSLRPETTRIPSPCFTNGRTKAVLISQPGQKTQANVTMVGTDGGFHACRRLVEVIMDKDAVCTSRPCSFGGVYQPSLMETFKTAPIMALSYFYDRLEPLGLGPKFTIDQLEALAQRACAYTKSDTQDFDAKAIAELEDRPETCLDLSFMHGLLSLGYELGGEREVSIAKKLGGTELGWCLGAQLAVLDEDGLVCKV
The following text describes a protein:
Function:
Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.
Sequence:
MKVMKFGGTSVGSVNSILSVKRIVESAGEPVIVVVSALGGITDKLINTSKMAAAGDSAYEGEFREIVYRHVEMIKEVIPAGAGQVALQRQIGELLNELKDIFQGIYLIRDLSPKTSDTIVSYGERLSSIIVAELIDEAKWFDSRTFIKTEKKHNKHTIDADLTNQLVKEAFHSIPKVSLVPGFISSDKVSGDVTNLGRGGSDYTAAIIAAALDASSLEIWTDVDGFMTADPRVISTAYTISELSYVEATELCNFGAKVVYPPTIYPVCHKNIPIIIKNTFNPDGVGTVIKQETSNPQSKAIKGISSINDTSLITVQGLGMVGVIGVNYRIFKALAKNGISVFLVSQASSENSTSIGVRNADADLACEVLNEEFAKEIEMGEISPILAERNLATVAIVGENMKHTPGIAGKLFGTLGRNGINVIACAQGASETNISFVVDSKSLRKSLNVIHDSFFLSEYQVLNLFICGIGTVGGSLVEQIRCQQQKLMMENGLKLHVVGIIDAAKAMFSREGFDLANFREELQKKGKDSNLQTIRDEIVGMNIFNSVFVDCTASPDIASLYKDLLQHNVSVVAANKIAASSAYENYRELKTIARQRGVKYLFETNVGAGLPIINTINDLIHSGDKILKIEAVLSGTLNYIFNKISADIPFSRTIKMAQEERYSEPDPRIDLSGKDVIRKLVILAREAGYHIEQEDVEKNLFVPNDFFEGSLDDFWKRVPSLDADFEARRQVLEKEHKHWRFVAKLEDGKASVGLQEVGANHPFYGLEGSNNIILLTTERYKEYPMMIQGYGAGAGVTAAGVFADIMSIANV
The following text describes a protein:
Function:
Involved in lipid metabolism and lipid droplet (LD) morphology, number, and size. Facilitates initiation of LD formation, and ensures that vectorial budding of LDs from the ER is directed towards the cytoplasm.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Concentrates at endoplasmic reticulum lipid droplet junctions.
Sequence:
MGYLVKLFKLVVWMLVIGLFSIPSLVSYVIFYDTVIPHSVIQYPVYFNYTTGLNFPTAEVRLDHFSIDPRLPGTSLLQIKMPHSPRNSAMGNFMVSVDFQDRNQRSLKQVKRTVLLPHRSPIHEYLKLIVCSPLYFMGILEETDIVNVRLFESETFAKSFNSITTLSVRFSVKNTPAQAIVKIYSKDIEFYEATLAFASKLHGMRWFMYTHKVSAFLVFTSLFWFTGITSTIITYLIVSSTSETKATRR
The following text describes a protein:
Function:
FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
Subcellular Localization:
Bacterial flagellum basal body. Cell inner membrane; Peripheral membrane protein.
Sequence:
MEKILTKQEIEALLAAVFEGKIEPDRELAKEEGTVHSYDLFNSEAHKGLVPNLDIIYDGFIRYQRGTLSNRLGRIVEIKKLGAGSYKFDDFIQTLPSPVCMAIYKADPLKGAALIAFDSTLVFTIVDCILGGTGMTSVQTSANRMFTSIELRLVQKIVQDMLVDLEKAWAPLYAAKMSLLRMEMNPRLVNIVPPEYQVVTMEMQIQIDQLEGKMVFAVPYMTIEPIRDKLKSGAQFDLMAIDPQWSFRLSKELLEAPLDVSVEVGGAVISLNDLLSLVPGDTIMLDTPCTSDLTVKVGGVPKFTGMPGIRHGNKALQITNVVGKGEQR
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Sequence:
TSFRLNSLTILPSCIVFLVLCSLVTVSFPSLGVGFYKSSCPSAEAIVGKPVNKVGCEASVLLKSTPGNPLEREHVANNPSLRDIIAFAARDSSYKLGGINYDVPAGRRDGRVSREDEVGQNLPPLFFNAQQLADNFGRKGITYSIGVSHCSSFCSRLYNFNATHAQDPFMDPRYAAFLKTKCPPPSANGVGGDPTVALDPTPNRMDNKYYMKSKKNGGLLTSDQTLMNGASTQRMVVNNARSPGTWANKFAKAMVHMGSLDVLTGTHGEIRRQCSVVN
The following text describes a protein:
Function:
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGPV
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVKYHFQGLSDNKVKENREKYGSNTLPPVEIESFFSKLMENFQDPLIHILCVALVITVILSFVGYAEWFEGVGIASAVFLATFVSTYSEYKNENSFQELQEKASRVKCNVFRNGSHISEVYGFDVVVGDLVLLQAGDKIPADGRLVAGELHVNQSTLNGEPHLEKKIVAPENYEPTTRNDFLDHYLCFRGTVVEDGEGVLLVSAVGSSTLYGELAIELSKADERESPLQIKLSNLADGISTIGYIGAGFIVISFLFKQFVMDNNYNWSEISTYISNYPIVLKDIVNSITLAIIIIVVAVPEGLPMMIAIVLSLNMRKLLKAKVLVRKLLGIETAGSLDILFVDKTGTLTKGKFIPRTFISGSAHTYKGFNQIPKELREVLSFTVRESTSSVIGEDGQIVGGNASDKALLQFLDKESLLADYQVKVEKEILFHSERKYSAALLKVPLSGGPTGKAPKGIVTCSHKLKNDERYVEITCLKGAPEIVLNRCTSHFNEDGHIEPIPDSVGLTNSINSLSEQGIRVIAVAVSREPLVETETLPNSLILVGIVGVYDEIREESRSSIQTARSAGIQVVMITGDKKETAIAVAHQIGLISPGEESQPGVVLTSFELQNLSDNKLANMLPHLRVVSRALPSDKVRFVNVAQSLHKVVGMTGDGVNDSAALKHADVGFAMGSGSEVSKEAADIVILDDNFASITQAVLYGRTIYKSIQKFIVFQSTINVASTLIVFLGPFMGFDFPLTLIQLLWVNLVMDTLAALAFGGEPALTRYMQEKPIKRDQSIITSRMWGSILGGGPFISAMSILFLTNDYVEAFFTRNGEPYQPAFLTAFFAFFIFLSVINAFNVRTSRLNLFDHLFDNKGFIVVVFFIFFVQIVFTYIGGKILRTVGLTSSEWALVVAMSFSVIPFDLIRKFALNLFLFKSKKNINKTD
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC31.
Sequence:
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLELNSRK
The following text describes a protein:
Function:
Plays a role in pattern-triggered immunity (PTI) signaling induced by pathogen-associated molecular patterns (PAMPs). Acts as a receptor for PIP1 defense peptide. PIP1 is an endogenous secreted peptide that acts as elicitor of immune response and positive regulator of defense response. Involved in the control of seed germination speed, in tolerance to oxidative stress and in maintaining seed longevity.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MAPSLRNFNFFHRFSTFLVFSLFSVVSSDDLQVLLKLKSSFADSNLAVFDSWKLNSGIGPCSFIGVTCNSRGNVTEIDLSRRGLSGNFPFDSVCEIQSLEKLSLGFNSLSGIIPSDLKNCTSLKYLDLGNNLFSGAFPEFSSLNQLQFLYLNNSAFSGVFPWKSLRNATSLVVLSLGDNPFDATADFPVEVVSLKKLSWLYLSNCSIAGKIPPAIGDLTELRNLEISDSGLTGEIPSEISKLTNLWQLELYNNSLTGKLPTGFGNLKNLTYLDASTNLLQGDLSELRSLTNLVSLQMFENEFSGEIPLEFGEFKDLVNLSLYTNKLTGSLPQGLGSLADFDFIDASENLLTGPIPPDMCKNGKMKALLLLQNNLTGSIPESYANCLTLQRFRVSENNLNGTVPAGLWGLPKLEIIDIEMNNFEGPITADIKNGKMLGALYLGFNKLSDELPEEIGDTESLTKVELNNNRFTGKIPSSIGKLKGLSSLKMQSNGFSGEIPDSIGSCSMLSDVNMAQNSISGEIPHTLGSLPTLNALNLSDNKLSGRIPESLSSLRLSLLDLSNNRLSGRIPLSLSSYNGSFNGNPGLCSTTIKSFNRCINPSRSHGDTRVFVLCIVFGLLILLASLVFFLYLKKTEKKEGRSLKHESWSIKSFRKMSFTEDDIIDSIKEENLIGRGGCGDVYRVVLGDGKEVAVKHIRCSSTQKNFSSAMPILTEREGRSKEFETEVQTLSSIRHLNVVKLYCSITSDDSSLLVYEYLPNGSLWDMLHSCKKSNLGWETRYDIALGAAKGLEYLHHGYERPVIHRDVKSSNILLDEFLKPRIADFGLAKILQASNGGPESTHVVAGTYGYIAPAEYGYASKVTEKCDVYSFGVVLMELVTGKKPIEAEFGESKDIVNWVSNNLKSKESVMEIVDKKIGEMYREDAVKMLRIAIICTARLPGLRPTMRSVVQMIEDAEPCRLMGIVISKESDVKVKEIS
The following text describes a protein:
Function:
Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MKAQTALSFFLILITSLSGSQGIFPLAFFIYVPMNEQIVIGRLDEDIILPSSFERGSEVVIHWKYQDSYKVHSYYKGSDHLESQDPRYANRTSLFYNEIQNGNASLFFRRVSLLDEGIYTCYVGTAIQVITNKVVLKVGVFLTPVMKYEKRNTNSFLICSVLSVYPRPIITWKMDNTPISENNMEETGSLDSFSINSPLNITGSNSSYECTIENSLLKQTWTGRWTMKDGLHKMQSEHVSLSCQPVNDYFSPNQDFKVTWSRMKSGTFSVLAYYLSSSQNTIINESRFSWNKELINQSDFSMNLMDLNLSDSGEYLCNISSDEYTLLTIHTVHVEPSQETASHNKGLWILVPSAILAAFLLIWSVKCCRAQLEARRSRHPADGAQQERCCVPPGERCPSAPDNGEENVPLSGKV
The following text describes a protein:
Function:
Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D-galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D-Glc4O) and L-glutamate.
Sequence:
MIPFNAPPVVGTELDYMQSAMGSGKLCGDGGFTRRCQQWLEQRFGSAKVLLTPSCTASLEMAALLLDIQPGDEVIMPSYTFVSTANAFVLRGAKIVFVDVRPDTMNIDETLIEAAITDKTRVIVPVHYAGVACEMDTIMALAKKHNLFVVEDAAQGVMSTYKGRALGTIGHIGCFSFHETKNYTAGGEGGATLINDKALIERAEIIREKGTNRSQFFRGQVDKYTWRDIGSSYLMSDLQAAYLWAQLEAADRINQQRLALWQNYYDALAPLAKAGRIELPSIPDGCVQNAHMFYIKLRDIDDRSALINFLKEAEIMAVFHYIPLHGCPAGEHFGEFHGEDRYTTKESERLLRLPLFYNLSPVNQRTVIATLLNYFS
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MIQLLFTLIFAEMALIVIFVFKTPLRKLVIMGLDRVKRGRGPIIVKTVAGTLFVVMLSTIYSIASIRTRWMDEGGDITPTDQILLAQHLLEASLMGFSLFLAFMIDRLHHYIRELSMRRKTMEAVKKQNRAFEDGKSGASEEIKTLEEEASALRGKIKQLESELQEKAKEASGAEANAVALKKQSEGFLLEYDRLLEENQNLRSQLQSLDRTLSRSDSKKVS
The following text describes a protein:
Function:
Major pollen protein required for pollen fertility and development. Active in both diploid tapetum and haploid microspores.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MGRQNIVVVVALVFMAIIGLAAAASSPSPSASPSKAPAASKTDHVEAPVTDDQIGTTDDDAAPTPGDGDVAVAGPLGSDSSYDNAPTGSADSAKSGAAALGVSAVVVGVTSIAGSFLLL
The following text describes a protein:
Function:
Functions as part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit that coordinates the first two steps of ribosome biogenesis in transcription of the primary transcript pre-RNA and pre-18S processing (By similarity). During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MQSSRKIMILKRNIKGLKSSAIIATYLTLNKLFIDKFCKTQESTYPIHFVHCHFGGIKKFHSHCQLSSSYTNSGQKSFKSFNSLRFIVLKSKTCLLRYKLLIKTFCCITYSKIENLSNTRMARLTAPSKGPSFSNLNKPNDLLKAEIEDNEASHYSQNQSSDSDSDEAPEEVSLKSSSDEVKKRLQRLKGNELQLRKAEREKRRLQNERNRERNAQRVSASKLDLAILEAAEVEEINSTTEIEEKVDEASLDLYTPKGHKIVFPNNEIPKKRTRSFRKGDFKVSVLKETNDPLLAPNYEKKLSQRKRDWINRQSVPRASKRRRPLTY
The following text describes a protein:
Function:
Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA.
Sequence:
MFKRKTAWFSDSVEKEVISFWVSEGGDISSWKTAGYLFSDDASSEDTKRIYGSEDYVKNRATVFHSSFLLACQPRQSVTSVPIGHYVLPPDFVQNEMKAIIGRFIWEKDEQVICEEQINPEVPKDILSGETEDHALRERSSQDDYQTVTSQSKVCSCCEMRQYPVNNMISGYVHIDQMRKYSGELKDFLPSLHGHDVSRSNDPTPPFHRKAV
The following text describes a protein:
Function:
During the post-exponential growth phase transiently interferes with RpoS (sigma S) activity without affecting expression of RpoS itself. It is probably not an anti-sigma factor as its overexpression is detrimental in rapidly growing cells where there is almost no sigma S factor. There is a strong overlap between Crl-activated genes and FliZ-down-regulated genes. FliZ acts as a timing device for expression of the genes for the adhesive curli fimbriae by indirectly decreasing expression of the curli regulator CsgD.
Sequence:
MMVQHLKRRPLSRYLKDFKHSQTHCAHCRKLLDRITLVRDGKIVNKIEISRLDTLLDENGWQTEQKSWAALCRFCGDLHCKTQSDFFDIIGFKQFLFEQTEMSPGTVREYVVRLRRLGNHLHEQNISLDQLQDGFLDEILAPWLPTTSTNNYRIALRKYQHYQRQTCTRLVQKSSSLPSSDIY
The following text describes a protein:
Function:
Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors. Acts as a regulator of the unfolded protein response (UPR).
Subcellular Localization:
Membrane.
Sequence:
MAFTLYALLQAGLLVVNAIAVLHEERFLRHVGWGSDQGIGGFGEEPGIKAQLTNLIRSIRTVMRVGASQSSASSSSWNQSCCSQHTWLFSYPQHVLRAQSCCEVLSRWLLPLVCSAAALEMR
The following text describes a protein:
Function:
May be involved in recombinational repair of damaged DNA.
Sequence:
MLLALRVKDFAIIDEITLDFHDGLNVITGETGAGKSLLVDALAFLLGERASTDIIRSGSNRSVVEAMFTMNEEVERLLDEWEIPKEKDGTLLVSRELNKSGRSKCRVNGELVTVGMLERLLSNIVEIHGQHEHQKILHRDFQLEVFDRLGGEELLDQKNKVKELFLKLRNLYSERDEIYGKEKERQQRIDLLSFQIEEIEKANLRIGEEEELLEERQKLQNYEKVRVGIEEAIKFLYENPEGMSAFEQLGEGLDIIRSLSSMDENVGNIVSLLENAKVYLGEAVDNLIRYKDSMSFEPSTIEEIEERLYRISQLKRKYGKNIEEILNYKEKAKEELDMLSNMEARLENIEAEISAVEEKLLYESEKLSEMRRNMVEDFVKRVEEELSELGMEHAKFAVEFMEPSSGLNINGVKISEKGREVIEFMLSSNPGELFKPLRHVASGGELSRVMLALKTILNEVDNTPVLVFDEIDAGIGGETAYLLAQKLWNISKKRQIFCVTHLPQIAAWADYHFHVEKKVVNDQTRIRVSMLEDKSRILELSRMLGGSIVSDVSQQHAKELLVKASELKSRGALNDRGGEN
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). The Cas4 region acts as a ssDNA exonuclease, while the Cas1 region acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).
Sequence:
MGIHSLLYCERLFYLEEVEGILVADDRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKGLSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
The following text describes a protein:
Function:
Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Sequence:
MQQSTQRRFFRKKYCRFCAEKIDFIDYKNVKLLRGFMTERGKILSRKLTGTCSKHQRELTKAIKRARAVALLPYIEI
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEISSHQFHLLQQLNEQRRQDVFCDCSILVEGKVFKAHRNVLFASSGYFKMLLSQSSKETSQPTTATFQAFSPDTFTVILDFVYSGKLSLTGQNVIEVMSAASFLQMTDVISVCKTFIKSSLDISEKEKDRYFSLSDKDANSNGVERASFYGPGWRAESSPPHPHLSPDQGTGAMGGNSWSNYNYYPPSQRNVQPPLSKHEQRQDSNKKSTRHLALPQSSDVPPYKTSKQEDRASEPAGPNPQPEEQIDAEVDSTHGGYQYDRGCDVTPRNLTGSQQEHESPRSASKSPKADESYANMPLILGVMGSWTEDDLPRMRFKCPFCTHVVKRKADLKRHLRCHTGERPYPCEACGKRFSRLDHLSSHFRTIHQACKLICRKCKRHVTDLTGQVVQEGTRRYRLCNECLAEAGIDSVPIDLDAEQSVASSSDGEKGSRWHLRGEESRSYVEIVEDGSADLVIQQVDDSDDEEEEKEIKPNIRAEESGYSKMGTMVWCTVDSIFICF
The following text describes a protein:
Function:
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition.
Sequence:
MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Subcellular Localization:
Nucleus.
Sequence:
MLQSMSGADDRKRALTGTVEDGPRKRLHSDEATSKSAATPTNDNEDDEALHPAYAGLEAFRKEAIYRKLLEARRDLQRIERRAGTFQDDLAVSEQRAAVLQRFWNLLLTELAARLAIQDQDVFALSSASDSRSDLTAMEQQLEQQSSAVLRCLSQQGDVNIVELQQKLHDLADEGSRYKQDLFLTQSKLQRAQDALAQTSQKLSKVEHEYVRYQSNLLRATEGKPTIPAGTIVSASEPAPATEQTADTAVKKETATLAPTDGAPHTSETLQKAVDELESARQDVELTRRESDSRYAEIQTLNEEVRTLKCKLHETQTKLTTLPEEVLLSSALYRELQTLLRNAQQDLQSSKEAMQALETEATALREDRAAFQQTVEAEAASRSEDLEKLIKAKEADVTRLRSQRDELNAELTERRSREQVKFTQIEEMKALLNSKEERLILLSSQVRRLRMAVAAFHGQSAGVSALATAESEEDQFEQVSRAAQQAQARVAELEQRLGVAGQNASPNGTGATAKTEKGADVDTKAEKSVEAASESELQGEIQRLRLSLQAAEASSKAVDDELEKISAAYADLERQASVKVTDVSRMEEKALRWVTEKSKADNKYFSAMRAKDAVDAELRTAKQVHERQQKTIEAFADVERNYVVQSGLHEKAISTFKKVTDAQTHRIETLQRELELAESRLTELARVKEVASDSAKELINTANLEKDQRKRAEERIVRLEKDLESSKRQLAKAAASAAKNKGRRDADAGDGASEKDFLNALLQCSSCKERYRNRILTKCYHTFCSECIDSRVQTRQRKCPHCALAFAVSDVQPLYLQ
The following text describes a protein:
Function:
Does not exhibit any ribonuclease activity.
Subcellular Localization:
Secreted.
Sequence:
MAPAVTRLLFLQLVLGPTLVMDIKMQIGSRNFYTLSIDYPRVNYPKGFRGYCNGLMSYMRGKMQNSDCPKIHYVIHAPWKAIQKFCKYSDSFCENYNEYCTLTQDSLPITVCSLSHQQPPTSCYYNSTLTNQKLYLLCSRKYEADPIGIAGLYSGI
The following text describes a protein:
Function:
Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi.
Subcellular Localization:
Golgi apparatus membrane; Single-pass membrane protein.
Sequence:
MYFLHGTPQRIQLSSRAIQICRIPKVSFFVVLTETEILIYQIRPLTLISKITKSQNLFERHGKNKKIAVNSEYGIIAVATEKNYVAVYHFTLNASKPVLTPSPYLTRYDDGPGEIFGPIKCEIQYKLAMRYGGGLKCLEIQRDSIVYAADSAPIIQVSTLETTDPNKLWKVSSKQYDLREVTWFLDHSSLISRLYFDVKIDTFFWMSTDGRVYANIGVSSNTNTKSLFGLCVHNPVDLNKSDNDKDINEDLESKLREKKATVLSTNARFSLLYVGTADGTVYAYEIRDFGRQYVQTHSFKYSASSGKVNHIATTGDGHQVMVGYDDGWATLSPYLNLCCASSETEYFNFGLSCGFWDRDSSSFYGLGSKNFSSTGEAEGTGLSTPIIAESLKENDEFFAMEKENVDIQYLSQNDNTNDVLYSITDSKQFISTIYILPFLKSTIVSSVQSTLQVCGAQTSDRLYISKSYEFCSSVKNNFGIDFWDQVEYPQPYVASEWPIRYVSIKDDGSLIAIAGLHGLAIYVCSKKTWFLYKDANMEQLISVTCPMIWCSQFLLAGVVCESNFELHLYKAKGPLDDRENLAKLSFTSTIVTMSVCDEYSLVVYTADNFLHHIRFDINELGRLELDYLTSVNFAPIFTTPSRVRSITLLLPKDLANIQPSDLLFYAVLLVLINGKLVLLSLKKQHSKELLYQCSMLAGDVEFYFINGSQEIPSLFHSIWIMTGKGLKLWLSFSEILSSVLINTKNLIDGLPKFLNTSKRVSLENFHRLSVEDLRSPSFVYKNGVDCNFDNTHLAKLIKNVNISEKFQKECIDLESQGCLLTVLSNYGLLLTAYTQGHKNLVNKMEYAHIQIGVYPFLPEIVRALLLLDKREQAIDLVKTYGHLHYINFVLEKLLSSSLLTYNSSQRDKLLYEVSLLFKDLQEFTTFKIVLGCLRKTEAEYWPMIFKYFGEPKDLMKKCLETEDVKSAAECLIIWQIHQGSASCASTFLSIYEMALKIKNWDVCTELSSYLVSLDPEKRLLKTALELLDEGPDSKDIRLYDQFNNLMKEVDKY
The following text describes a protein:
Function:
Ribosome-binding protein involved in ribosome hibernation: associates with translationally inactive ribosomes and stabilizes the nonrotated conformation of the 80S ribosome, thereby promoting ribosome preservation and storage.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Colocalizes with gamma-tubulin at interphase, prophase, metaphase, and anaphase. Relocates from centrosome to midbody at telophase.
Sequence:
MPKKFQSENTKSAAARARKAEAKAVADAKRKKETEDAFWQDDDKHVVRKEHRKEEKEKKRLELLERKKESQRLLDEEDSKMKGKPTKPAAPSKVTRAQIEETLCKEEKHKDAPEKPKTHLEIPLEENVNRRVLEEGEVEARTVEDAIAALSIGKELDRHPERRMKAAFTAFEEINMPLLKQENPNMRLSQLKQLLKKEWMKSPENPMNQKYATYNSH