lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the MCD1/SCC1 subunit of the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Miscellaneous:
MISCELLANEOUS: Present with 4090 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin except at centromeres, where cohesin complexes remain. At anaphase, the MCD1 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
Sequence:
MTAVRRSTRIRTKSQVIEEDYDDEQNTSAQHVESDKITAKTQHEEEEEQDTGESEESSSEDDYEDQDDDDYVDTATAKRKSRKRKPKSASNTSSKRQKKKPTSAQKSAVSHAPAYHRSKKDQDQYLEIAKDFQPTELFDILSTSEDVSIEELLREWLETYSENRDKFLQEFINLLLNCCGSVARVEDHDVHSNESSNETIGEIQLLFQRQKLHEFYLLISKENKKRKNFKMGPLYQNFAEFMTKLLEVANDLQLLYVESDEDDTQIVTGNLVLDLLTWLSSFSVCKIRCFRYISTLTLYLFQDYLTQQAVNLEKNYLAKLSKQLSLEEKKKRPNNKTLEKLESTIAETQGSKVVIDSIIDNIVKLCFVHRYKDVSDLIRSESMLHLSIWIKNYPEYFLKVTFLKYFGWLLSDNSVSVRLQVTKILPHLIIQNHNSKSTDNSAIRQVFERFKTKILEVAIRDVNLDVRIHSIQVLTEASSLGYLDDSEILIISSLMFDEEFDPFKTSSFNKRSKFLSTVAKFLARVIKEKFDEFIKTHEDLPKEVDGLEVGPVVQVGIFIKILNDSLIYHLKDCAEVDSRTKIRMLTQAAEFLSPYISTHLKTICNLLISDTESNELIQKLQNSANNNSDDEDVDDEELDITPLFPIDRNSTILYLNVFHGLCAGANNPKIQTKDSVKEIVLPLFYDLLNAASIESADILCPLLESFITFSLDDWISIGYETELKKITDKTIKAFMDSTIGNSKVDMKYDIFAKFIHHIHHFEKKELQEKFLNQIATLKIHLKKFLQEKMDPNNSRDDYKDLTCSLYELYINKLTILGRDYPIEVDEELLQLFLNNFVSRIPIMFQDFDDSTAQEINFKMLVLLATWNLEKWREIIEKVRDYENSISKDLRSVWKPIAAIIGRLNTLVISLAATNETFENINSLFYLKWSACTSLMDIIVAIKIFELKLPADATTWRYSMSEQFPFYLHDNASKVLLKIFLYLESLFAKQVDVQLERVADEDANLNDLPETGFFENIETEFLLFTVKLKGLMKLNILDERFASRVALNKEKLGPLFKKIVDDTIMENPEPNKKNIQKAKSNQTQREKAPLQPNSERETDHANTENNDPDIPMTIDLEPIEESSQNNSELAPIEEHPTVVDAIDNSDEITQD
The following text describes a protein:
Function:
Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.2 is required for proteasome assembly.
Sequence:
MDNEIPFVERLGNIVDPKDPNVPLTQRAALLEDLIDEVIQDGAHIEERVGDFEQVLNHLLETYVQLANSEKFATLLDHLAEYFTKIPKARTAKLVRIIIQALRKVPGTLEIQADLCQKWITWAKDQERTLLRQRLETELSEILLEQHKYNEAIEILQRLTAELRKVDHKSQLIEVHLIESRTFRGLGDFSRAKASLTAARTNAAAVYTAPLLQGQLDLESGILFNDDGDYRTASSYFAEAFDAFANAGDPLALDALKYRLLCRILDGKASECPAIEAAAAIFLQNSKNAIVQKNTQIETMLEIARASEAKSLHDLLDVIKKRKDDLNADPVVASNVKNLINSLEEQHLLRIVKPYSAVQLSRIAELIHLDVEQVEAKLVQMILDQKLKASINQADGILNIFEDEEANEILTESIDLIENMDGVVDALYNRCKLMN
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MPKFNANGLLRSFAAEMKKPWTAESLWYETVAKHPPTFQYARRIVPLYDPNKVKSRGKRLRKSMYQPQEIQWPEDKLRKRFYRDHPWELARPQIIAENDGNDQQYCDWSHMDQPRKALSGESVVQRTLWLIENSNMPVENAYDQARKEFYHLRAEQEIQQRVAHDQAQALGAVFTKSDLELGYEMDQNALNSWFDNASQYAEANRTKFTDPSVDISKTTQ
The following text describes a protein:
Function:
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIRASHPLSENYCTAESIINGIIMFCNLIGCYYRALSSNFCFVCSFFVFSCPNVIFCEAVAIYGVIVAIIRQTKLESVPTSKMYDAESLRAGYAIFASGIIVGLPTLYAGLLCVGIIGSSCALSDAQNSTLFVKILVIEIFGSALGLFGVIVGIIMSAQATWPTK
The following text describes a protein:
Function:
Zinc transporter that may mediate zinc uptake from the rhizosphere. May also transport other divalent cations.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MARTMTMRVSSLLVAVVLLAALSFQACSGHGGINDGDGQVDAPATPASSSGVRSKGLIAVKVWCLVILLVFTFAGGVSPYFYRWNESFLLLGTQFAAGVFLGTALMHFLADSTSTFKGLTTNQYPFSFMLTCVGFLLTMLSDLVIAAVARRSAAAGVSDNQVSEQQQRQQAEGAVMSRKEEEAAAVAHPAMLVRTSSFEDAVLLIVALCFHSVFEGIAIGVSASKSEAWRNLWTIGLHKIFAAVAMGIALLRMIPKRPFLMTVVYSLAFAVSSPVGVGIGIAIDATSQGRAADWTYAISMGLATGVFIYVAINHLIAKGYRPHHPTAADKPLFKFLAVLLGVAVMAVVMIWD
The following text describes a protein:
Function:
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide bridged cyclic dipeptide. The first step in gliotoxin biosynthesis is the condensation of serine and phenylalanine to form the cyclo-L-phenylalanyl-L-serine diketopiperazine (DKP) by the NRPS gliP. GliP is also able to produce the DKP cyclo-L-tryptophanyl-L-serine, suggesting that the substrate specificity of the first adenylation (A) domain in gliP is sufficiently relaxed to accommodate both L-Phe and L-Trp. The cytochrome P450 monooxygenase gliC has been shown to catalyze the subsequent hydroxylation of the alpha-carbon of L-Phe in cyclo-L-phenylalanyl-L-serine whereas the second cytochrome P450 enzyme, gliF, is presumably involved in the modification of the DKP side chain. The glutathione S-transferase (GST) gliG then forms a bis-glutathionylated biosynthetic intermediate which is responsible for the sulfurization of gliotoxin. This bis-glutathionylated intermediate is subsequently processed by the gamma-glutamyl cyclotransferase gliK to remove both gamma-glutamyl moieties. Subsequent processing via gliI yields a biosynthetic intermediate, which is N-methylated via the N-methyltransferase gliN, before the gliotoxin oxidoreductase gliT-mediated disulfide bridge closure. GliN-mediated amide methylation confers stability to ETP, damping the spontaneous formation of tri- and tetrasulfides. Intracellular dithiol gliotoxin oxidized by gliT is subsequently effluxed by gliA. Gliotoxin contributes to pathogenesis during invasive aspergillosis. In macrophages and neutrophils, gliotoxin showed inhibition of various different cell functions including cytokine production, antigen presentation, phagocytosis, and production of reactive oxygen species.
Sequence:
MAPGLLENNTLSGTAAPRTEFKAIVNDLRELQAHVQRVQSAIEAPEVQSWLNEQLHHPDQLPDKELEQLALDLVDSMDKLQLQLVPSVSLLTDGFFGYLNSKTLWTVVEAQVADRLAENGPQPVSTLGLRCGIQPERLAQLLDTLVSNGIFAYNPADDTYSNNRASLLLCHDHWTQWHLWADLYPNEFFDVSRAMPQAVRLGESRTAAQIAYGTDLDLFEYLAKEQKLAKFQKTLGAGAVAQARGLTVDYPWEEIGSEPILDIGGGSGAFLASLLRAHPHLRGSLMDIQSVIELITPEFREPHGRFSDIGSRVQQLVVGDFTKQIPPSAVYTMKWCLHDWVDDDVLTILKNVRRSIVPSSVSRFLVVESIKSPGRSGRLPRYGDLIMMITCNGKERSLEDWKRLGELAGWKLYQVHRVRRAWPCIIDFRPM
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MEKQIKRNHSCKHKICRRTRYRNYKFCYLHILDDKSAPFTTCQYISNVTKRKCSNPALKPDRSNSTVPCLCEIHNNAKSQTNRIKYRSHRKKNSKLADRDYQPTLLQKLRKHHKSNDGEAKHNTDDESGQPYDLAMEQLELDTYENRQWVTGLSTSWKSGEADIDVDLVEDLNNPLKYAGAYTAEEVISMSKDRLVRLQSLYIDQFKHLHRTLQEGRRKYLVDKSIEEQQGSSHSSSKQLSSRSEHHHLHELKSLVGFRRRSGEEILLHKKLKKRRLEITKGKTVMPLEAQPHRSRCSHVTKNTRCKSSCLPYTKYCTAHILEDPLQIMYKKCNWKGCTIPVCVMSLEQSKQKAQCFCPAHRKLPEFSQKLEKLVSNIGEANTVIVTDNVSVKEETKEQDVEIAEVLGDILTTVEDGLNIINMETLIEPKEEMVNGIEDDKEEVIPIPPPVVDDTPMILVEEDSMGVEEHQVESHPPMDVDPPEDVDFSKSSSVINSISTGQLFMVSNSPDEGALHLEPLIPSLSSHGHTVSVLPSENNNDSCEKFLREKGYAENAETESRQSVTLEIGDAKQSKSIEAKVQHQGAIISVSNERTKYEKTSKKIVTTTLVPPVETKRETSDKEEHLEE
The following text describes a protein:
Function:
Ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity). Has an appetite-stimulating effect.
Subcellular Localization:
Secreted.
Sequence:
MPLRRRASHMFVLLCALSLCVESVKGGTSFLSPAQKPQGRRPPRMGRRDVAEPEIPVIKEDDQFMMSAPFELSVSLSEAEYEKYGPVLQKVLVNLLGDSPLEF
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MALYRKYRPASFAEVVGQEHVTAPLSVALDAGRINHAYLFSGPRGCGKTSSARILARSLNCAQGPTANPCGVCESCVSLAPNAPGSIDVVELDAASHGGVDDTRELRDRAFYAPVQSRYRVFIVDEAHMVTTAGFNALLKIVEEPPEHLIFIFATTEPEKVLPTIRSRTHHYPFRLLPPRTMRALLARICEQEGVVVDDAVYPLVIRAGGGSPRDTLSVLDQLLAGAADTHVTYTRALGLLGVTDVALIDDAVDALAACDAAALFGAIESVIDGGHDPRRFATDLLERFRDLIVLQSVPDAASRGVVDAPEDALDRMREQAARIGRATLTRYAEVVQAGLGEMRGATAPRLLLEVVCARLLLPSASDAESALLQRVERIETRLDMSIPAPQAVPRPSAAAAEPKHQPAREPRPVLAPTPASSEPTVAAVRSMWPTVRDKVRLRSRTTEVMLAGATVRALEDNTLVLTHESAPLARRLSEQRNADVLAEALKDALGVNWRVRCETGEPAAAASPVGGGANVATAKAVNPAPTANSTQRDEEEHMLAEAGRGDPSPRRDPEEVALELLQNELGARRIDNA
The following text describes a protein:
Function:
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Sequence:
MSKANVLKLNSDNAVRIENYRQSLYKQAEDLFSNYIPLKISHLDNLLKGDEFSITDLSSLHAPLDIPIPDPPAPEDEEMETDKNEDDEKKKKAPKCGFIKGNERIVKLLDIVKPEIMGLKETCITVSCWIAHLIPKIEDGNDFGVAIQEKILERITAVKTKVEGFQTNINKYFSERGDAVAKASKDTHVMDYRSLVHEKDEAAYSEIRVIVLDIRGFYAELYDVISKNLEKVTNPKGEEKPSMY
The following text describes a protein:
Function:
Together with EX2, enables higher plants to perceive singlet oxygen as a stress signal in plastid that activates a genetically determined nuclear stress response program which triggers a programmed cell death (PCD). This transfer of singlet oxygen-induced stress-related signals from the plastid to the nucleus that triggers genetically controlled PCD pathway is unique to photosynthetic eukaryotes and operates under mild stress conditions, impeding photosystem II (PSII) without causing photooxidative damage of the plant.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MPSLSTPPSQNLAFSPAASATSSRLTPSSKRSFYPHRLPDPTALCRCSSSSGSNSSSSSSSDDNPRWDSAIQDVLKSAIKRFDSVLSWYATLDNDDGEQGSENVEKIDDDWDWDRWKKHFDQVDDQDRLLSVLKSQLNRAIKREDYEDAARLKVAIAATATNDAVGKVMSTFYRALLEERYKDAVYLRDKAGAGLVGWWSGISEDVKDPFGLIVQITAEHGRYVARSYNPRQLSTSAAGAPLFEIFLTLDGKGNYKKQAVYLKWKEIFPDVPTMPSRTLTPGRFLTSPGRKEDTGNLAVESSEDEESDNSDDDSDLLEESSGFQSFLRDMIPGVKVKVMKVTAPGRVDKDFISKVIEQIADEEDEENDLDIEDIDVEDDTKAEIDEKNADIELESVTDEIIDNNGGREIAVKFVIGDIVDRLSGNQPLKESLRSPANLESVENSSFYLRLEKDLNVKESKGVEGTTLVDGKGSRQSRRRIENIMGDLAKSIEKEKKISVKMLKDVGELLSLTLSQAQNRQQLSGLTKFRRIDVTPSLDPLDGLYIGAHGLYTSEVIHLKRKFGQWKGGKESKKPTDIEFYEYVEAVKLTGDPYVPAGKVAFRAKIGRRYELPHKGLIPEEFGVIARYKGQGRLADPGFRNPRWVDGELVILDGKYVKGGPVVGFVYWAPEYHFVMFFNRLRLQA
The following text describes a protein:
Function:
Involved in the regulation of the late steps of the endocytic pathway.
Subcellular Localization:
Late endosome.
Sequence:
MFSNFFGSSKRNTIASSSSSSKKDKDNGKDESSKLKNSGSSTLPKPITNNESGNNFITSPSVSSPLISPLSSSPSPLLSSSSNSIQSTSHQQQQQHQGVITSLQMKPSCTSLTDDIEKKKQAKYDSSLEQTARKWVCDVLEIQLEDDKTFYELFKNGVLLCRLINKLRGGTIKRINESTISFKQLENIENYLKACKTLGLQSVNLFNSIDLHENKDISLVITNIVVLGKHASKIEGYNGIHLAGERKIIKITTTPVSPLFGGNHNNNNNNNNNNNTSNGDLSPVSITSASGGSSNYNSYSNNPLNKSSNGKKAKWRKSVKIPAVSSLNSDIRTKEAFKFSPELQKAAQDWIEEVTKEKFKLPSFSSSLKDGILLCRVINTIIPNTILYINNGNSSFKKMENIGNYLKGCLVVGLKKTDLFDTPDLFEEKNINFVISNIHVLGNHVNKMYSHLKLPLIKNIGNGGNGGNGGIGGGGGSDGSPLKMYSSIIHSKFGNGSSNTSSGNGGVIIPPEDMKDLKDWINHHLRAHHSLQIGSDMSNDLRNGVTLLTLLEELTLQKVGIFAREPVLPWHFMQNICLLLNFLRENSVHNVSDISPHDLFNGDIHSLCMITRLIRENFDTDHQMKSIPMDTRRQKVIEEIIATEQSYVKSLSTVYNLLIVPLLNSLDTNSPILSNDEISSIFGNWEHLLRSHINLLKEFKLKLNLPFNDLTIDDSNQNQNHNNIFGDSIFDSNITIGDVFLEKCEFLKDNYTNYINNYDNSYQRVKRLKKSNSNFEELVNTFEIFQDTHNGLDLYSYLIMPIQRIVRYILLLKEVIKYTPSTHPDYQMLQNAKENIKRVADHVNESKMAVENKRKILSIQDSIQNLQFNLMDKERTYIREGFLEIEDTFKKDSYFFLFSDLLLFVKYKPSEETGKEFKYKEVFYLDQVVDVSDILSDDEGEACVDGDDDGGEYEGGNGDATSGSADPEDQTLRRSCNSNNNNNSNSNKSNTVYSFEIETCEFSLVLLAESHTEKIEWMEDLRSCLQHQLIKEEDQLSSLSLSDNDDDNDADADVESSLNSISSPLLLLNNNNIINNNNNNNNNNNNNNNNNNNNNNCKNSNININSSIDNNSDNNNNDYDSKINSEENGDSSDEENKTSNRRSVSFKTHKRLESDETISDTESDDYELVCGRSKKSQPPPVPPRKITFSDTIKNIDNQ
The following text describes a protein:
Function:
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state (By similarity). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion.
Subcellular Localization:
Cell junction, hemidesmosome. Nucleus membrane. Basolateral cell membrane. Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane (By similarity). Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.
Sequence:
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLREFWMDGNRLTFIPGFIGSLRQLTYLDVSKNNIEMVEEGISTCENLQDFLLSSNSLQQLPETIGSLKNVTTLKIDENQLMYLPDSIGGLRSIEELDCSFNEIEALPSSIGQLTNMRTFAADHNYLQQLPPEIGNWKNITVLFLHCNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDTETQKMVLTNYMFPQQPRTEDVMFISDNESFNPALWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEESGRDLKQHEDQQVVNKDKCVKTSESTTTKSKLDEREKYMNSVQKMSEPEAETNGGNLPVTASMKLSGNLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIESSINQPKVVALSNNKKDDAKDADSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTPVDSNSKVRQEDENFNSLLQNGVNLNNSPEEKFKINDKKDFKLPEYDLNIEEQLVLIEKDIDSKATSDDSRQLDHINMNINKLVTNNIFQPEVMERSKMQDIVLGTGFLSIHPKNEAEHIENGAKFPNLESINKVNGLCEDTAPSPGRVEPQKASSSADVGISKSTEDLSPQRSGPTGAVVKSHSITNMETGGLKIYDILGDDGPQPPSAAVKIASAVDGKNIVRSKSATLLYDQPLQVFTAASSSSELLSGTKAVFKFDSNHNPEEPDIIRAATVSGPQSTPHLYGPPQYNVQYSGSATVKDTLWHPKQNPQIDPVSFPPQRLPRSESAENHSYAKHSANMNFSNHNNVRANTGYHLQQRLAPARHGEMWAISPNDRLVPAVTRTTIQRQSSVSSTASVNLGDPTRRTEGDYLSYRELHSMGRTPVMSGSQRPLSARAYSIDGPNTSRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNTRVGSEHSLLDPPGKSKVPHDWREQVLRHIEAKKLEKHPQTSSPGECCQDDRFMSEEQNHPSGALSHRGLPDSLMKMPLSNGQMGQPLRPQAHYSQTHHPPQASVARHPSREQLIDYLMLKVAHQPPYTHPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFHNAVDLIIVREVSS
The following text describes a protein:
Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival. The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form.
Subcellular Localization:
Secreted. Endosome lumen. Note=ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR.
Sequence:
MSMLFYTLITAFLIGVQAEPYTDSNVPEGDSVPEAHWTKLQHSLDTALRRARSAPTAPIAARVTGQTRNITVDPRLFKKRRLHSPRVLFSTQPPPTSSDTLDLDFQAHGTIPFNRTHRSKRSSTHPVFHMGEFSVCDSVSVWVGDKTTATDIKGKEVTVLAEVNINNSVFRQYFFETKCRASNPVESGCRGIDSKHWNSYCTTTHTFVKALTTDEKQAAWRFIRIDTACVCVLSRKATRRG
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs.
Sequence:
MTETIGLKRKASQDDLKSLAEGESNKSIKTVESINSDLHSSEDTRNKGMLRVKPEYRLLSSSKDTQNSNYDDDGAEAAGVAHTSGSSKHKNRGQNKPKDRKQIVQHDSIRLCNKFATGEQCNLGSNCKYSHDIQAYLAEKELDLGPVCPQFALLGECKFGIKCRFSKAHTDAEGNQMVAEKKLNEDQFIKNCSTKSIIQDIKQKNIDCTRSKEFIQWWSAEEIKLQQRLNELKKRKEEPRAGAEATLIPLRPNEKKKIDFRGKSYLAPLTTVGNIPFRRVCKSYGVDITCSEMAIARQLLRGSPQEWALTRRHASEDMFGIQLASNDPTQFTQTVEILSQKVDCDFIDLNMGCPIDTMTKSGNGSALLERKNKVRGMLLGAVHVSSVPITIKMRIGLSNKKKIGHKIIPLARDCGVAAITVHGRSKEQRYTKLSDWDYTMECAKMTKMTWHSPDASTVTPDWVTEPPAFFGNGDVFSPQEYWDHVDHSTDSELPLAGIMVGRGALSKPWIFKEIKERKLWDISSGERLDMLKDFTKFGLECWGSDTMGVNTTRKFMCEWLSFLYRYVPVGILEVLPQRVNERPEQFVGRNDLETLMASDNSKDWIKITEMLLGPAPESFQFIPK
The following text describes a protein:
Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAPKAGNKQQSEEDLLMQDFSRNLSAKSSALFYGNAFIVSAIPIWLYWRIWHMDLVQSAVLYIVMTLLSTYLVAFAYKNVKFVLKHKVAQKREDAVSREVTRKLSEADNRKMSRKEKDERILWKKNEVADYEATTFSIFYNNTLFLVLVIIASFFILKSFNPTVNYILSLSASSGLIALLSTGSK
The following text describes a protein:
Function:
May be the encapsulin shell protein in a type 4 A-domain encapsulin nanocompartment system. Its cargo may be upstream glyceraldehyde-3-phosphate dehydrogenase (AC P61879).
Subcellular Localization:
Encapsulin nanocompartment.
Sequence:
MENNNIMSQVKEIIEAAIKELEDDGFEPDIILAGPIFIRYLPEDVRLKVYEIEELGSDAIIADSKYLGQIKKAAKRISIDPLLQEKEWEKIIEEIPTQE
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC33.
Sequence:
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLDATRRAR
The following text describes a protein:
Function:
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Plays a role in the regulation of lipid metabolism.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MAATGETAAMDGASGSKGQGQESHEEELTSASGLPPSQRKLVLLMTHLNIAMYSTCFWIQQGALPYLTKKLGVDPVVYGYLQTTFAVVQLCGGPLFGRFGDLFGTRSALVLAFSAAAMSYGLLGMAEGMLLLFLSRLPSFLMHSMQGAQMIVTDISDEGNRADALGKLGLSYGIGMIVGPFLGGQVTKYFSEQHSAYLAMAGSLVSIVLVVLFIPSNTKAGKKDSDSKKEDSGPSSVFDVKAIAKLLTIPVAAYLLLVRTIVGTPLGIFQSMFSVIAMDRFNIGPEENGYLMSYIGMSNMVMMGLGVGILTKRYNEGLLLKWAIYMFTFGYLLLAGANVTWHIYVTVIPLTIGGTIMNTVISSTLTKVVPPDSTGTMLGLSMASNSIIRTMSPTVGGLMLGYAGYPSFGVLGFVVNTLLSVYMVFSQTHAKVVAAVEKQSARKES
The following text describes a protein:
Function:
Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein. Membrane; Single-pass type II membrane protein.
Sequence:
MMGKRKAPSSSSTPPGQKAKGPRQDSGAADGSLPERRSFVHGSAFLIVCFACFLLGFRLSWEGKAAFLGAYRIGPESGKLVLRDTGTSLDYADSESGGGAAQGGLDLRPGAWESGQGDKYGAGVADGEWERIETRILASAGGVVNASESNRSRRLLPRPPPSPPEHPWVGRHNISVRPWPHPDAGETLLAHALIAAVQREQQNQFGVPLDRRKRMIVVTPTYRRAFQQIHLSHLTDTLRLAPEPLSWLVVEAGGPTEETQAILSKTGLADIHLLPVPGVTMPDVRAPERPIVEDYLRDVALGYIQKQAMEGVVVFADDSATLRLALFQELQKVRWFAAFSVGMLVQGGGSQVDLPVQGPVCGPEGDVRGWHAADHELLRLKKPAVVPKRALLGAAEKRLPGGEGAQRRLLALEVPERTEGFGAGSDSISQLGAGTVVRQLQQVEQSEYFEPELFIPKLEWVGFAFNARLLWAPAERPAWLREWKPSTTLGKVDAVVGDYEGDEDPTDLLARMVEDESQVETLGRCGKDVLAWWLKVEAAEEGQYPAGWRLAENLPVVAEPQEWSEEQWAEYEARLVEEKKKKKKKKSKKKKKAPEATKVEEDAAARQAAEQAAADEARRVEEEKQRELEAARQAEEERQTRLAEAQKAEVEDNLDSVQKAKAEVRTDPEKEGEKAESKLESSALAEKEALTNNAKEVLNKLVEGADGGVADDTQAREKQTS
The following text describes a protein:
Function:
[CLE1p]: Extracellular signal peptide that regulates cell fate.
Subcellular Localization:
[CLE1p]: Secreted, extracellular space.
Sequence:
MANLKFLLCLFLICVSLSRSSASRPMFPNADGIKRGRMMIEAEEVLKASMEKLMERGFNESMRLSPGGPDPRHH
The following text describes a protein:
Function:
Probable mannan synthase which consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosic polysaccharides of plant cell wall.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MAMAGADGPTAGAAAAVRWRGGESLLLLLLRWPSSAELVAAWGAARASAVAPALAAASAACLALSAMLLADAVLMAAACFARRRPDRRYRATPLGAGAGADDDDDDEEAGRVAYPMVLVQIPMYNEREVYKLSIGAACGLSWPSDRLIVQVLDDSTDPTVKGLVELECKSWGNKGKNVKYEVRNTRKGYKAGALKEGLLRDYVQQCNYVAIFDADFQPEPDFLLRTIPYLVRNPQIGLVQAHWEFVNTSECLMTRIQKMTLHYHFKVEQEGGSSTFAFFGFNGTAGVWRISALEEAGGWKDRTTVEDMDLAVRAGLKGWKFVYLADVKVKSELPSNLKTYRHQQHRWTCGAANLFRKVGAEILFTKEVPFWWKFYLLYSFFFVRKVVAHVVPFMLYCVVIPFSVLIPEVTVPVWGVVYVPTTITLLHAIRNTSSIHFIPFWILFENVMSFHRTKAMFIGLLELGGVNEWVVTEKLGNGSNTKPASQILERPPCRFWDRWTMSEILFSIFLFFCATYNLAYGGDYYFVYIYLQAIAFLVVGIGFCGTISSNS
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
Subcellular Localization:
Nucleus.
Sequence:
MGIKGLLQWIKKTHPEVIKAFSKRWADPKFHGKLVAIDATLLTNRFHFASRGGPLEGYGEVIGWYNLVSEMRAYGVIPVAIWDQRGVREWKSAEARRRLTIRAAHLARRNHEFTRSARVHLLREAITDFFHLPSEEQDAVRAHWQATKFTFVTTGRKDALDGDQILAGGALTPPESSRTEKIERKAMEGLQGDQEEKIKVVQDEDRVLTAEENEQMKQKTTAEKIASSLTERDTISINRITSTIDTFSYLVQAYRDSYRPPLPSSKTKPSPSLPGFDPSQDLTPLEEELKQWTAANRQELGLDEWKKGVEKLDEKLEDLVPLENFTETRRQLDLTREEGEIINLVLSPPPPCADYPTPPPSPSFQTASEPSPSSDALIRLSNLIATLPSVLSIYQRALDIPSPADHLNCQHLLHLLRVPILHAPIPFEAEGLASSLCLSGLADYVGTEDSDVLGYSAKLLRNVSSLRKPLEVVDGEEIRQVVELEKDEWVDWMVLLGTDASNNIPKIGPVNSLRFVKEYRSIENILGAKPKLVDRLNVLHPEGAPKGMEEWMKGVEAGRKLFKELPPTPTLAEWEELWTGVGTVEETDDKVVQLWLEEKFGVKLVELEDADLYKLEGNESGVGGESESESQNGNEDETDVVRL
The following text describes a protein:
Function:
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the nucleus in absence of PIK3CG/p120. Colocalizes with PIK3CG/p120 in the cytoplasm. Translocated to the plasma membrane in a beta-gamma G protein-dependent manner.
Domain:
The heterodimerization region allows the binding to the catalytic subunit.
Sequence:
MQPAATTCTEDRIQHALERCLHGLSLGRRSAPWSAGLCLNCWSLQELVSRDPGHFLILLEQILQKTQEVQEKGTYDLLAPLALLFYSTVLCTPHFPPDSDLLLKAASTYHCFLTWPVPYCSICREMLTFIDAELKAPGISYQRLVRAEQGLPVRSHRSSTVTVLLLNPVEVQAEFLAVADKLSTPGQSPHGTYTTLLLHAFQATFGAHCDLPKLHRKLQSKTIEELEDIFTETTEAQELASGIGDVAEAREWLRTKLQAVGEKAGFPGILDTASPGKLHTIPIPVARCYTYSWNQDSFDILQEVLLKEQELLQPGILGDDEEEEEEDLEMDRHCAERDSLLSTSSLVSHDSTLLLTSSQASEPVLSRQMLTTFVSGLSDGMDSGYVEDSEENSEWPQKPGSQKRQGHRRPGQKFNRFYKLLKSTSQLVLRRDSRSLESSVDPTLPLRRAGSLCSPLDCPAQLPSRAQRSRSLPQAKLTTQLPRWLLAPPSHHQRRRPFLSGDEDPKASTLRVVVFGSDRISGKVARAYSKLRRLETSHPILTRFFKLQFFYVPVKRSHGTSPSACPSSLSQASPLPADSLKYPSPTDLGMAPWEDSTNDISHYLGMLDPWYERNVLGLMHLPPEVLCQQSLKADSRPLEGSATQLPILADMLLYYCRFAARPVLLQVYQTELTFVTGEKTTEIFIQSLELGHSATTRAIKASGRGRKRLGIDDDREAVPLTLQIIYSKGAISGRSRWSNLEKVCTSVNLSKACQKPEELDSSMEALTLTLTEVVKRQNPKSKKGFNQISTSYIKVDKVQIIGSSSCPFAVCLDQDERKILQSVVRCEVSPCYKPEKSSLPPERSFSQPAETGSDLCSLLCLPIMTFSGALP