lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSFDGLIVENENTKSGYNDGNDLTDLFKQNGTDMSVINSLLGDTNNPGMNESPKILDSSFENSNPQDGPNYEDFDFMGSIHKEFGNNINEMDDMEDVSDDNLPEEEQAVNYTGDKDDEDFGKLLAKEMGEEAAGQVLSGVGFSIPSGLVPPSEPSKTVSSTTEELQNEAQIRESIVKTFFPTFERGVLLNFSELFKPKPVKLAPPKKKTPKVCVPGRLTLEVDTDYAIIFNSKKSLPLKRNVVSPISTHTKKRRRTANTSQRNDGLDLNTVFTTNDWEKNIIYDESDVNKTNQSSFFIDKSLVDIDFAFDENIFDGDTGTSKVVLNLNDPKLLLQPQLPKKEDSQRSFADTHQRNSLAWKFNISNDPAYEMLKQNHQSKVRNTLSQLAIEHAAFAEKLTFPYYKTRLSKRAVRSYHRPTMSFKPNAAIVFSPLIVRKRSKDKHKSERELIPTTKEITMGDTTHAILVEFSEEHPAVLSNAGMASRIVNYYRKKNEQDESRPKLEVGESHVLDVQDRSPFWNFGSVEPGEITPTLYNKMIRAPLFKHEVPPTDFILIRNSSSYGSKYYLKNINHMFVSGQTFPVTDVPGPHSRKVTTASKNRLKMLVFRLIRRSPNGGLFIRQLSKHFSDQNEMQIRQRLKEFMEYKKKGDGPGYWKLKSNEVVPDEAGTRSMVSPETVCLLESMQVGVRQLEDAGYGKTMDEINDDEDEEQPAEQLLAPWITTRNFINATQGKAMLTLFGEGDPTGIGEGYSFIRTSMKGGFKPAGETADDKPEPQTKNAHAYNVAKQQRAYEEEINRIWNAQKRGLSINNLEELAKKYGINSIHDDYVESNEETTREETPSSDKVLRIVRLYRDKNGNLERKQETIHDPIVIHAYLKKRREIDEQSTALDAVVPTGDEAIDRRNRRRLEQELAKSQKNWERRRARHAAKEGINLNGEGRKPTTRKCSNCGQVGHMKTNKICPLFGRPEGGLATMLDKN
The following text describes a protein:
Function:
Involved in the biosynthesis of cobalamin (vitamin B12). Catalyzes the oxidative fragmentation and contraction of the isoalloxazine heterocycle and the cleavage of the ribityl tail of FMNH(2) to form 5,6-dimethylbenzimidazole (DMB) and D-erythrose 4-phosphate (E4P). NAD(P)H is only required initially to reduce FMN and oxygen drives the oxidative fragmentation (By similarity).
Sequence:
MNFEQTHRDALTEVLRWRRDVRHFRPDPIDEAVIDRLRAVMDMAPSVGNARPWRVIRVDSPALRAEVLANFNAARAAAGSAYAGEQAEAYATLKLQGIDQAPLQLAVFTHRDPAAGHGLGRASMPVTLQQSTAMAFTRSGCRAGENLGLGMVSVLDPKAVERLLNAPPDWDFVAWLCIGVPEFTDDTPLLHRAGWQENLPTEWERR
The following text describes a protein:
Function:
May regulate actin polymerization.
Sequence:
MRTLIERYYSQYYFIDTTITDPNLTEDQYVNQHTNELAVIGVAPSHPVLQQEISKIEFKENAINNEVSGVRKTGGFKLQSNTILCVITCSNGKEYFLRSCIKGKLLEINKELINNPSLLKTNHATSGFLAIVEPMIKDKFMENPGLIKFEEYHKLRNIPIQKGPVFLKDNTNDED
The following text describes a protein:
Function:
May have a role in the remodeling of the endoplasmic reticulum upon zygote formation.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MLRSAGRVAAVALLALFALGCVSAAAKPSTDRLVAAIKSKNLSAVVDALSVKGLDVNTPDSTRRLPLVEAARSRDARLVGALLDQGALARVSDGTTTPLHLSMQGGSAAIVKLLLAHGADPNAKDKTGASARSTAAAVKELADLLKQWDARGAMAFEDEPGAWIREERDGQSYYWKPANGESRWAVPPSCAWQRVTVQGHPIKYINSLTGQETTRVPPALAWARVTAADGSALWLNWASRVASAAATAPAELPAELAAELAMHPNRRWYNTATREYVYTDPAYATPWRELVDEASGAPFFFNVETGDTTWELPAALAWTEVIESSSGADGESGSGSEAGPRYFHNTVSGEVAWSAPEGSRHVFVEASAADL
The following text describes a protein:
Function:
Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MSSTQDEAILRNARETIDSLYDLSQLLQTGLDKSTLSICVGMIEQGANPDTLAAVIKELRSENEALNSQSNA
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MADENSRSLLVVIFDANPVAWGGIAVEGNETQISLTRCLESLMVLCNSYLLLKHNNLLAFVAASTNGSKFLYPKASCEGIQSLPSQDSKYEKFSEFNDTVLREIKKLVGAAQSTVGAKLQPRILIIKASPDDASHYMPVMNSIFAAQKSNTCIDACVLYEHSGYLQQATDITGGVYLKIPETQALLQYLM
The following text describes a protein:
Function:
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.
Subcellular Localization:
Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.
Sequence:
MRLLLLLAFISVIPVSVQLLDARQFLIYNEDHKRCVDALSAISVQTATCNPEAESQKFRWVSDSQIMSVAFKLCLGVPSKTDWASVTLYACDSKSEYQKWECKNDTLFGIKGTELYFNYGNRQEKNIKLYKGSGLWSRWKVYGTTDDLCSRGYEAMYSLLGNANGAVCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDKDKLFGFCPLHFEGSERLWNKDPLTGILYQINSKSALTWHQARASCKQQNADLLSVTEIHEQMYLTGLTSSLSSGLWIGLNSLSVRSGWQWAGGSPFRYLNWLPGSPSSEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNNTLNPFIIPSASDVPTGCPNQWWPYAGHCYRIHREEKKIQKYALQACRKEGGDLASIHSIEEFDFIFSQLGYEPNDELWIGLNDIKIQMYFEWSDGTPVTFTKWLPGEPSHENNRQEDCVVMKGKDGYWADRACEQPLGYICKMVSQSHAVVPEGADKGCRKGWKRHGFYCYLIGSTLSTFTDANHTCTNEKAYLTTVEDRYEQAFLTSLVGLRPEKYFWTGLSDVQNKGTFRWTVDEQVQFTHWNADMPGRKAGCVAMKTGVAGGLWDVLSCEEKAKFVCKHWAEGVTRPPEPTTTPEPKCPENWGTTSKTSMCFKLYAKGKHEKKTWFESRDFCKAIGGELASIKSKDEQQVIWRLITSSGSYHELFWLGLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPGMSWNDINCEHLNNWICQIQKGKTLLPEPTPAPQDNPPVTADGWVIYKDYQYYFSKEKETMDNARAFCKKNFGDLATIKSESEKKFLWKYINKNGGQSPYFIGMLISMDKKFIWMDGSKVDFVAWATGEPNFANDDENCVTMYTNSGFWNDINCGYPNNFICQRHNSSINATAMPTTPTTPGGCKEGWHLYKNKCFKIFGFANEEKKSWQDARQACKGLKGNLVSIENAQEQAFVTYHMRDSTFNAWTGLNDINAEHMFLWTAGQGVHYTNWGKGYPGGRRSSLSYEDADCVVVIGGNSREAGTWMDDTCDSKQGYICQTQTDPSLPVSPTTTPKDGFVTYGKSSYSLMKLKLPWHEAETYCKDHTSLLASILDPYSNAFAWMKMHPFNVPIWIALNSNLTNNEYTWTDRWRVRYTNWGADEPKLKSACVYMDVDGYWRTSYCNESFYFLCKKSDEIPATEPPQLPGKCPESEQTAWIPFYGHCYYFESSFTRSWGQASLECLRMGASLVSIETAAESSFLSYRVEPLKSKTNFWIGMFRNVEGKWLWLNDNPVSFVNWKTGDPSGERNDCVVLASSSGLWNNIHCSSYKGFICKMPKIIDPVTTHSSITTKADQRKMDPQPKGSSKAAGVVTVVLLIVIGAGVAAYFFYKKRHALHIPQEATFENTLYFNSNLSPGTSDTKDLMGNIEQNEHAII
The following text describes a protein:
Function:
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKCKPNQTRTYDPEGFKKRAACLCFRSEREDEVLLVSSSRYPDRWIVPGGGMEPEEEPGGAAVREVFEEAGVKGKLGRLLGNFEQNQDRKHRTYVYVLTVTEILEDWEDSVSIGRKREWFKVEDAIKVLQCHKPVHAEYLQKLKLGGSPTNGNSVAPSPPEGDP
The following text describes a protein:
Function:
One of the primary rRNA binding proteins. Located near the base of the L1 stalk, it is probably also mobile. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is highly controversial; In the E.coli 70S ribosome in the initiation state it has been modeled to make several contacts with the 16S rRNA (forming bridge B7b, PubMed:12809609); these contacts are broken in the model with bound EF-G.
Miscellaneous:
MISCELLANEOUS: This protein can be partially replaced in vivo by its H.marismortui (HmaL2) or human (L8, from the 60S cytoplasmic ribosome) homolog.
Sequence:
MAVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKSGGRNNNGRITTRHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVDAAIKPGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRSNKRTDKFIVRRRSK
The following text describes a protein:
Function:
Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MHEIFYTGCGKVGNTLATHLDRKGHEVLLYDINEEVVKKINEGIHPYVEGIRFKNVKATTDLNQINEFKNLICALPVQVIPKVITKVNLKGKNFISASKGIIHENLKRISQLVKEIEPKLKFFVLSGPSFAEEVSKGLPTAIVLAYEDKEEAMKLQDALDSENFNVYLNDDITGVELGGALKNVIAIAVGLSDGMGYGYNARSAIITRGLHEMANVGEKFGARRETFFGLSGAGDLILTSTSDLSRNRTFGKLLGQGYSVEEALKKINQTVEGVKTAEALYEIIKRENIFAPICEGVYRIIKGEDPKKVYPHFLSNHLREEFQR
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Sequence:
MPLGLIGEKVGMTRVLLKDGTAIPVTVIKFPVNYVVQVKSQNTKDGYNALQIGAYEAKEKHLTKPLIGHFKKHGVPLLRRLWEFRVDNPEEFQSGQQLKVEDVFKPGDLVDVWGISKGRGFAGAMKRWDFAGFPKSHGHRYHRAVGAIGQRTDPGRVWKGKRMPGHYGAKPVRVQGLFVVDVLPEENAILVKGSVPGHNKGIVVVEQSTIAYRKSQKLKQKRYQFIIENLAKEESQEVAES
The following text describes a protein:
Function:
Involved in the organization of desmosome cell-cell junctions. Of particular importance in cell adhesion in the skin and during cardiac development. May also play a role in the regulation of Wnt, TGF-beta and Hippo signaling pathways.
Subcellular Localization:
Cell junction, desmosome. Cell membrane.
Sequence:
MSLSGSQTRLHQISRRSSSRPDLTAVGYSLPRNDGAQFFTSGNGYQSDYNDGYMQTYTQTFSKNSQGGGAGGAQSMSSMAVQKRAQMLYSDCMGFLQRAQGLLETMGPASEVDKNMMAAQDAMDQLRKCAVDMRNAGLPNDMILRSLEDCHSFYADIRNSITGTTIRRTGGTVSGTIGGTISGTIGGTVGGWDDPSKSFQDALSWINQKKRLIETSGFGENSEAISQQILNHNKFHSSIQRSQEVDRARDDLMQSREKAGLHALDQEWDSLQKMSHARMDHLRDLQSIIEEISRAIMWVNDREEEELVFDWGDKNIDNYIPQKQESYSKLMSDLEEKEKELNKLKAKVDMLLKNQHPASDKIEAYMDTLQTQWSWLLQITKCIHVHLKENAAYSQFFKEANETYSRLQKDHENIRKKFGCDKTTPLENLNDMLKNLEKEKEKVIENKRQVQTLVSKSKNIVCLKPRNPEEKSSSPVIVQALCDFKQDQKGIMKGNEGILKDNSQRSKWHVTGPGGLEMLIPSVCLIIPPPNPLSISLANKNEQYYEAIMSIWSQLYINIKSLISWQYCLRDIQHINSLTLSMLTQMRPEEYRQTIKNLEIHYQEFLRNSLGSEMFGDDDKRKMELQYAGAQSHYDQLVIQLPNYRENGVIREVVMVETDSKLKSEVSSGKTATGVSSGKTATGVSSGKTSSSVSVSGLNVSLLSDLSALRRRLETAESGLTKHLHVPLKENSVQECSQRLAQLQAVHRDLDSIRDEYLHLREKIMRELEGSSDPEQSRYLRAELDLINQKLGSLQGFSSAYIQRLGALQALLQHLLQAEDIIKVHEARLTEKETSSLDLNEVEKYCMTLKTMKAELEQKKGVLKAMETELSKAVHWNSQIDQSFHQCDVDLSRYTELVGQMTDRWRRIVTQIDSRTWDLEKQEKQLNHYQQTSSTINRWIQDTRQRQDTLQITKFNSVDNLMDHLNQQKALYSEIKGKKEKVDAVVKDSDTCAASIKDYELQLASYSAGLETLLNIPIKKTMLQSPATVLREEATDLQSRYIELLTRSSDYYKFLGEMLKNMEELKMRNTKIELLEEELRRLKDNLKDQNQKNKSLEDSLTRFRLELTQSKEQLISMEEVKRTQARQCNTAQESLDSTQNQLKSLQDEMSRLTFLIEEEKRKRRLAEERYTNQQEEYELAMRKRQKELEELTLSKSQFERAIKEKEREIERLKLQLQDEASRRSAAELETSKTSMMIQRSDSNYKDIVQERDSLLIKLKLLQQDKDKQQRYEEELRRIKLTLESETKQKQRLQDEIDKITKDFKYWKSQYELKEGQIRQSEMDRDRVERDRASLQSEIQRLTAELRSVEERYRGRLQSSDKEISELMRKKESLEIELRRLQQRPAATWKQTQTDEISKPVVEQKLTVQGLRGEVSLTELVESDLLDQTDLDKINRGQLTSKDIEHKLKSYLGGSDCIAGIYDEAKDRVMPFYQAMKDGLLRRGTTLELLEAQAASGFIIDPVNNVCMTVEEAWKRGLVGKEFKDKLLSAEKAVTGYKDPATGKIISLFQAIEKEIIEKGHGIRLLEAQIASGGIIDPKGSHRIDVEVAYRKGYFDREMNEILSYEGDDTKGFFDPNTHENLTYLELKKRCIKDPKTGLMLLPLNDKQKPKQTTTQKNTLRKRRVVIVDPDTGKEMTVREAYHRELIDYDTFLELSEQECEWEEITIETSDGNKRLLIVDRKTGIQYDIQESLQRGIINKQTLEKYRAGTMTLTEFAALITSKSNSSELAIFSSSPEDVATCSSPTQPSSPTVRKRFASVSITLSPPSDIFDDQSPVGAIFDTETLEKITIPEAQRRGIVDNITAQRLLEAQVCSGGIINPATGQRLSLKDAVQQSLIDEDMSVKLKPAQKAYDGFEDVKTKRKLSAAEAMKEKWLPYEAGQRFLEFQYLTGGLIEPGTGRRVSIEEAIRKGWLDGKGAQKLQDTRNYIKNLTCPKTKLKISYKEAMDNCMVEENNGMKMLQATSMSTKGISSPYNVSSGPSSRSGSRAGSRTGSRSGSRRGSVDYSSSSVSYTFFSSAS
The following text describes a protein:
Function:
May play a role in signal transduction pathways that involve calcium as a second messenger.
Subcellular Localization:
Membrane; Lipid-anchor.
Domain:
There are 3 contiguous domains conserved in the CDPK subfamily: a kinase domain, an autoinhibitory (junction) domain and a calmodulin-like domain. The autoinhibitory domain (330-360) inactivates kinase activity under calcium-free conditions (By similarity).
Sequence:
MGSCVSSPLKGSPFGKRPVRRRHSSNSRTSSVPRFDSSTNLSRRLIFQPPSRVLPEPIGDGIHLKYDLGKELGRGEFGVTHECIEISTRERFACKRISKEKLRTEIDVEDVRREVEIMRCLPKHPNIVSFKEAFEDKDAVYLVMEICEGGELFDRIVSRGHYTERAAASVAKTILEVVKVCHEHGVIHRDLKPENFLFSNGTETAQLKAIDFGLSIFFKPAQRFNEIVGSPYYMAPEVLRRNYGPEIDVWSAGVILYILLCGVPPFWAETEEGIAHAIVRGNIDFERDPWPKVSHEAKELVKNMLDANPYSRLTVQEVLEHPWIRNAERAPNVNLGDNVRTKIQQFLLMNRFKKKVLRIVADNLPNEEIAAIVQMFQTMDTDKNGHLTFEELRDGLKKIGQVVPDGDVKMLMDAADTDGNGMLSCDEFVTLSIHLKRMGCDEHLQEAFKYFDKNGNGFIELDELKVALCDDKLGHANGNDQWIKDIFFDVDLNKDGRISFDEFKAMMKSGTDWKMASRQYSRALLNALSIKMFKEDFGDNGPKSHSMEFPIARKRAKLLDAPKNKSMELQISKTYKPSGLRN
The following text describes a protein:
Function:
Small polypeptide acting as a regulatory molecule which coordinates cellular responses required for differentiation, growth and development, probably by restricting polar cell proliferation in lateral organs and coordinating socket cell recruitment and differentiation at trichome sites.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MKMSERRVGSYRKSTLRCWDWCKEQRTRAYIIWRCLIFLLRWDDY
The following text describes a protein:
Function:
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm. Peroxisome.
Domain:
The KIS (K-channel inactivation suppressor) domain is required for converting A-type Kv4 current to a slowly inactivating delayed rectifier potassium current.
Sequence:
MNVRRVESISAQLEEASSTGGFLYTQNSTKRSIKERLMKLLPCSAAKTSSPAVQNSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEDTFKEIYSQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMDKNKDGVVTIDEFIESCQKDENIMRSMQLFENVI
The following text describes a protein:
Function:
Involved in the promotion of spontaneous somatic homologous recombination (HR) events, which is opposite to the function of FANCM in ordered HR. Only FANCM is essential for replicative repair in the absence of the endonuclease MUS81. Acts in the same pathway as FANCM to restrain class II meiotic crossing over (CO), and acts with FANCM during meiosis to repair interstrand cross-links (ICLs). This common pathway between MHF1 and FANCM is in parallel to the pathway that involves the RECQ4A helicase.
Subcellular Localization:
Nucleus.
Sequence:
MFNISYAKRNAKYLFKLLAWCMMIEEAGPNIGNKQKVVLQLSKMLIMYIILHINAAFWTWRGYLKRCVLHFVFPRIFLPLLSDSPTITQAKKPSYCFAMDVGGEDISDLQVDQIVEEYSMDDLIRDRFRLSAISIAEAEAKKNGMEIGGPVVACVADLAFKYAENVAKDLELFAHHAGRKVVNMDDVVLSAHRNDNLAASLRSLCNELKAKEPQSERKRKKGSAKKEDKASSSNAVRITTDL
The following text describes a protein:
Function:
Involved in the negative regulation of synaptic differentiation in PLM neurons.
Sequence:
MKKLASLQFFNLKLLLNGESSRGFSKFKKNYKLKAELGRGGFGVVYRAVRTCDNALVAVKFIERSNVKEWARINGEQVPMEICMLAKCSKVRGVIRLLDWYSIPEGFLIVMERPYPCIDMFDFIKGQGKISEDMARFLFRQIAVTVHECVQNRVLHRDLKDENIVIDLVTGSTKLIDFGAATVLRRSQYSDFQGTRLYCPPEWFLHSLYLGREAAVWSLGVLLYNSLNGRLPFRNEKDICTAHLLGPLPFFVPVSAEVKDLISKCLTFDPFQRCSLEAILNHPWVKQQTLSWDALTKNKVQKKTSESSDDHHSETLGDHSETEEDRSPPTSSVSQQPGSADEGVGLSASSSNTHNQKKPNHKEFRMAKTSLLAPPTSIEMKAAVQASKTPTQFNVHTALKNQRQIKKHHSPQPPNSTVLTALRRAMSREAQNRISGVFSQD
The following text describes a protein:
Function:
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
Sequence:
MNLTYSKLKIQWHDKDKPYSIALLRTLPLNTTLEKIEGISERGAATERVGDWVIEGISVYIGLGQPYTYLTDPGLEVKENPTSPNPTSLNCLRMSHNKTRRFKNHHPRRGQSTRGHKFIGEDECLPVDPANEEEPTRPNIHLAMWDFGQCDAKRCTGRKLARFGLLKEHAGENLMDGFASQVENVQNEELSKCDLRVNSGFGGIVLSPVGVNCVSKEDHSLLKQKGLAVVDCSWARLGDVPFVKLRCAAPRLLPWLVAANPVNYGRPCELSCVEALAAALIICGEGETADLLLGKFKWGHAFLSVNRELLKQYSACENSADIISVQNAWLSQQRQVPKEPHNVEGADKSSVSEHDEGSDDSEDGLPPLEKNLNHLTLQQESDEESE
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MSRLALLRNLVTQRQNLLPTNFARLKCAAAMHWSPHLRQEASRDGGGSLQRSQDNTQVSTDVRPIGEKIKENTKTASYTAIIIAGLGVTCVMFFAIFRELFSSESPNNIYADALRRVVEDPRVQDAIGAPIKGFGETSRRGRRQHVAHSSYERNGKPHMRMQFYVQGLRNKATVQLESRRSDSGKLEYRYLFVQLDHYPRTTIILEDNRAFDPTPEPASAGSSFGNLALMSNSRDK
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MRSTLASAQKAAVRIPKGFVFPVPKVKSAPKVSDTHPLWNFFRDKQALPPPSEEAKFGRAWAAEELRWKSFNDLHGLWYNCLREKNLLFTQRAEMKRLQLTIPKASNERVLAVNKTMAAIKFVLWERQRAYTSAKQLEKQKGSS
The following text describes a protein:
Function:
May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM).
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Major; MISCELLANEOUS: [Isoform 2]: Minor.
Subcellular Localization:
Secreted. Secreted, extracellular space, extracellular matrix. Note=Colocalized with fibrillin microfibrils. Predominantly distributed in baso-lateral regions of fibroblast extracellular matrix.
Sequence:
MGKLRPGRVEWLASGHTERPHLFQNLLLFLWALLNCGLGVSAQGPGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLPDCPPGAVPFRDLQCALYNGRPVLGTQKTYQWVPFHGAPNQCDLNCLAEGHAFYHSFGRVLDGTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYWNVTLIPEGARHIRVEHRSRNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHVVYTRDTGPQETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWLPRERYSPFQARVQALGWPLRQPQPRGVEPQPPAAPAVTPAQTPTLAPDPCPPCPDTRGRAHRLLHYCGSDFVFQARVLGHHHQAQETRYEVRIQLVYKNRSPLRAREYVWAPGHCPCPMLAPHRDYLMAVQRLVSPDGTQDQLLLPHAGYARPWSPAEDSRIRLTARRCPG
The following text describes a protein:
Function:
May be involved in the preferential repair of active genes.
Subcellular Localization:
Nucleus.
Sequence:
MEDKEQQDNAKLENNESLKDLGVNVLSQSSLEEKIANDVTNFSNLQSLQQEETRLERSKTALQRYVNKKNHLTRKLNNTTRISVKQNLRDQIKNLQSDDIERVLKDIDDIQSRIKELKEQVDQGAENKGSKEGLQRPGETEKEFLIRTGKITAFGHKAGFSLDTANREYAKNDEQKDEDFEMATEQMVENLTDEDDNLSDQDYQMSGKESEDDEEEENDDKILKELEDLRFRGQPGEAKDDGDELYYQERLKKWVKQRSCGSQRSSDLPEWRRPHPNIPDAKLNSQFKIPGEIYSLLFNYQKTCVQWLYELYQQNCGGIIGDEMGLGKTIQVIAFIAALHHSGLLTGPVLIVCPATVMKQWCNEFQHWWPPLRTVILHSMGSGMASDQKFKMDENDLENLIMNSKPSDFSYEDWKNSTRTKKALESSYHLDKLIDKVVTDGHILITTYVGLRIHSDKLLKVKWQYAVLDEGHKIRNPDSEISLTCKKLKTHNRIILSGTPIQNNLTELWSLFDFIFPGKLGTLPVFQQQFVIPINIGGYANATNIQVQTGYKCAVALRDLISPYLLRRVKADVAKDLPQKKEMVLFCKLTKYQRSKYLEFLHSSDLNQIQNGKRNVLFGIDILRKICNHPDLLDRDTKRHNPDYGDPKRSGKMQVVKQLLLLWHKQGYKALLFTQSRQMLDILEEFISTKDPDLSHLNYLRMDGTTNIKGRQSLVDRFNNESFDVFLLTTRVGGLGVNLTGANRIIIFDPDWNPSTDMQARERAWRIGQKREVSIYRLMVGGSIEEKIYHRQIFKQFLTNRILTDPKQKRFFKIHELHDLFSLGGENGYSTEELNEEVQKHTENLKNSKSEESDDFEQLVNLSGVSKLESFYNGKEKKENSKTEDDRLIEGLLGGESNLETVMSHDSVVNSHAGSSSSNIITKEASRVAIEAVNALRKSRKKITKQYEIGTPTWTGRFGKAGKIRKRDPLKNKLTGSAAILGNITKSQKEASKEARQENYDDGITFARSKEINSNTKTLENIRAYLQKQNNFFSSSVSILNSIGVSLSDKEDVIKVRALLKTIAQFDKERKGWVLDEEFRNNNAS
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin; overexpression prevents HigB-mediated cessation of cell growth and inhibition of cell proliferation.
Sequence:
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGGIAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
The following text describes a protein:
Function:
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MDSLLKFLLFLWSVHCSFAASKSRPITTTLETKWTRHSVTMEASEFIAEKSDAAFWNFLEHVAAYKEDFSHDEALYHFTLKMASRQLSVMEQDLLKWALSIHAYAPKIEMYHQIARSHHVPENCATFVDVHGELSCSLDNLDQLIADVGDRPKPNIFSVDHQYKRSVNGSVVAVLYGDISAYRSNVGDFHKVLAKKASSGDIQYVFRHYQMESSGAQIRLSGYGVELAIKSTEYKAVNEEENKDGSAKTDAEMDQGPDEIEGFVFSKLMELHPDLTEGLTQFKQKLVDNTNIMEPLKVWQLQDIAYQAAQRVLSTPPEDALQVLTDISQNFPLLARSLIRTQVKSEVQKEIKENQKLFAMNHNADKGDAIIMVNGLVIDTEVADPFMLLDLLKAEGKLLEGLHQLGVQGSSLTDVMKTKIESLQDSYAVDIRDNAVIYINDLESDKKYKAWPSHIQEFLRPTFPGMLRHIAKNVFHVTLILDPTSPDSMLLLDQAEMLYLSDVPLRFGFVFVVNDDDNVDGMDDAGVAMVRAFNFALMEEDAGKAMDLITKIHREADDGVTPGDVVTVLNQMFPGEDMEDIIGPESDYDDHRQDGAAFLRKTALRQTPQVLMNGVPLSKDELDPDVFEEAVVTNILMNTADFQRAVYRNKVGEHTDLLEYAMTRPNVMPRLNLKILKSDNPIIDLTGSPGSATVDTPLASHGLTSSHLTGLVADSIKYLTKKDDDAVRPVSMWIVCDLETEEGRQVARDTVQYVKASNNVRLGLVHYAPPSSQDGADAFWLVKAVQAAMETQTRNYAKNFIFKLLKEENFKSVQDGQKTPQDFEVNGMDMKAFTEAFNTPRVALRENHRAFSSDVLGLAPGNRAIVANGRVFGPFLPDEPIEVADFELIEKLITSNSATNVKNKLKNINVSAKDSSKRRDFASDMVMKTDALLASSSQSDSRKETQYWNKKHSMMNIPPRKPDQASYDIVAVLDPLTRDSQKWSQLLQVLHQGLNVNINIYMNPRAQLSELPLKSFYRYVLEPELAFRVDSSLTAGPSAKFLEMPLDTLLTMNMLTPESWLVESVRTRSDLDNIKLSEVSGEIVAEYELENLLLEGHCFEQNSGQPPRGLQFNLGTATQPVMVDTIVMANLGYLQLKANPGAWLLRLRHGPSADIYEIASHEGTDSSEGSEDVQVVMSSFKAKIVRMKVRKQPGMQNVDLLAGDGGKDDNGGGAGGGTGGGGGGIWNSISNSISGLTGGGGGGGGGTKGGAETGNGEMEQLNIFSLASGHLYERLLRIMMLSVLKHTKSPVKFWFLKNYLSPSFKEIIPEMAKEYDFEYELIQYKWPRWLHQQTEKQRMIWGYKILFLDVLFPLNIKKIIFVDADQIVRADMQELADFDLKGAPYGYVPFCDSRKEMDGFRFWKSGYWASHLAGRKYHISALYVVDLVKFRRIAAGDRLRGQYQALSQDPNSLSNLDQDLPNNMIHQVAIRSLPQEWLYCETWCHESEKSRAKTIDLCNNPLTKEPKLTAAVRIAPEWVDYDNEIKNLLERLANASLEEEEEESIEEEEEVEETNDEHKHTDL
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau. Involved in the acrosome reaction and in binding of sperm to the zona pellucida. Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (By similarity). May play a role in fertility and microtubule formation through interaction with RANBP9 (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Note=In mature sperm cells, detected in the acrosomal region of the head and in the middle piece of the tail. Localized to the nucleus and cytoplasm of spermatocytes and round spermatids while, in elongating spermatids, expressed in the cytoplasm but not in the nucleus. During the cell cycle, localized on the microtubule-organizing center (MTOC) during prophase. In metaphase, extends along spindle microtubules. In anaphase, detected on the astral microtubules and mid-zone. In telophase, remains at the mid-zone. After cytokinesis, returns to the MTOC (By similarity). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme (By similarity).
Sequence:
METTESTEGSLSRSCDVQPSSERLDTPSEPVPSSSSSPRSTAPAEAPAQYSVLTEPSSDSLYGAPCPPAHHRGHGFGFQPFYVSCIPQDPCNMADLSSRADPTSSYPCHSSVHGSGSGTCGLGQSSEPSQGSGPTSGPAPASVPSLVSGPDSASGPDSSASGPALASGPGPADPGQGPKFSTCIPQGYRCIPVDLAPDYNAWCQHLHWKPQRSWEPLQVSEPGVRGPYKPPEPGALGPCEPCEPCEPPEAESEETLCKARPRGQCLLYNWEEERATNQLDQIPPLQDGSESYFFRHGHQGLLTTQPQSPMSSSTTQRDSYQLPRHICQPLRGKREAMLEMLLRHQICKEVQAEQEPARKLFETESVTHHDYRVELVRAAPPASTKPHDYRQEQPETFWIQRAARLPGVSDIRTLDTPFRKNCSFSTPVPLSLGQPLPYELESGPHQVGVISSLACQGGGQGCGRTKTTPI