lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases 4-O-methylglucuronic acid from xylan (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MWSGIPIFALLSSIGIAAAETGLDGWLRYASVPCNGNCQRALPSHIVTLNSTRSSPVYVAGQELQDGLHQILGKHASVKSTGCSTDSSIIVGTVEAYRQVCNAGRQVPQFDVDGFWLSIREKSVLIVGQSERGALYGAYEYLSMLAQGNFSQVSYATSPHAPIRWVNQWDNMDGSIERGYGGPSIFFKDGVIRQDLSRVQQYARLLASVRINGIIVNNVNANASLLMPSNMDGLARIADIFRPYGIRVGISLNFASPSTLGNLSTYDPFDSSVIAWWGNVTDQLYARIPDMAGYLVKANSEGQPGPTTYNRTLADGANMFARALKPYGGVVMFRAFVYDHHISEDNWYNDRANAAVDFFKPLDGKFDDNVVVQIKYGPIDFQVREPASPLFANLYKTNTAIELQVTQEYLGQQSHLVYLPPLWQTILGFDLRVDQKPSLVRDIISGQRFDRPLGGWAAVVNVGTNSTWLGSHLAMSNLYAYGRLAWEPTLDSEDIVQDWIRLTFGLDRRIVDTLTQMSMESWPAYENYSGNLGIQTLTDILYTHYGPNPASQDGNGWGQWTRADHLSIGMDRTVKNGTKFSGQYPAEVAAMYENIETTPDNLLLWFHHVNYTQRLHSGKTVIQHFYDAHYTGAETAQTFVSQWESLRERIDAERYQHVLTRLIYQAGHSIVWRDAINNFYHNLSGIADEKQRVGHHPWRVEAEDMQLDGYVPYAVSPFETASNYTAIVTASNGTTGTASATLDFKTGTYDLGINYYDMYGGKSHWTVYLNDRVVGQWQGNSEDVLSHTPSIYLDGHSATRITFRDVKIHKGDRLKIVGKPDGVEPAPLDYVVVLPPGIVD
The following text describes a protein:
Function:
Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.
Subcellular Localization:
Cytoplasm.
Sequence:
MYGFVNYALELLVLKHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADDILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHLGTLYPGMRAPSFRCTEKDGELLLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAVATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALSTCPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFLCEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLNFENILSHINTIYVLQTRQGAMSSRHEQRFLRLKGQMMYIPETDRILFQCYPSVMNLDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPDHCEDHAKCMARVALDMMDMAKNVKMGSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRATSSILGGTSSTGSGGGGGNGSLDSPLLQPATPTAGGPRPFP
The following text describes a protein:
Function:
Acts as a chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription (By similarity). Acts as a histone-binding protein that regulates transcription (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Localizes predominantly in the cytoplasm. In the germline, following ionizing radiation-induced DNA damage, localizes to foci within nucleoli where it colocalizes with cdc-48.1 and/or cdc-48.2 and ufd-2, proteasome alpha subunit and ubiquitinated proteins.
Sequence:
MSKDDPINSIFFEHQEAALCAQHALNMLLQDALYKWQDLRDLAIQMDKMEQQILGNANPTPGRSENMNESGYFSIQVLEKALETFSLKLTNIENPAMVDYKNNPLTARAYICNLREHWFVLRKFGNQWFELNSVNRGPKLLSDTYVSMFLHQVSSEGYSIFVVQGVLPRSDADDLISLCPVVPPKVTPKKEQKLEKVMTKFFNTVGKRLGGGSGAPPDSQEEKDLAIAFAMSMETKDGSEVSRSSAEIDEENLRKAIELSQAPGPSEPAEIPLLTRSRSSTPPGASEPFSNAEQQRRDRQKFLERFEKKKEERNDEK
The following text describes a protein:
Function:
Acts as an osmosensitive calcium-permeable cation channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MADSSSTSAFISTLIIYGLTAVVFVWLFLLLRPKNRRVYEPRSLKDIQTIPEEERTEPVPEGYFGWVEYLLSKPHSFLIQHTSVDGYFLLRYIGIVGSLSFVGCLLLLPILLPVNATNGNNLQGFELLSFSNVTNKNRFYAHVFLSWIFFGLFTYVIYKELYYYVVFRHAMQTTPLYDGLLSSRTVIVTELHKSIAQEGEMQMRFPKASNVAFAYDLSDLQELCKERAKNAAKYEAALNKVLNKCVKMTRNKTQKQLDKLYNNGTKPKDDLETYVPHKKRPKHRLGKLPLCLGGKKVNTLSYSSKRIGELNEEIHEKQADWASNDRQPACFIQFETQLEAQRCYQSVEAILGKKNFGKRLIGYSPEDVNWGSMRLSSKERHSRRAVANTIMVLLIIFWAFPVAVVGIISNVNFLTDKVPFLRFINNMPTFLMGVITGLLPTIALVVLMSLVPPFIVMLGKLSGCVTRQETDLYSQAWYYAFAVIQIFLVVTATSSASSTVDSIIDRPRSAMTLLANNLPKASNFYIMYFILKGLTGPTWTILQAVNLLLSKVLGRVLDSTPRQKWNRYNTLATPRMGIVYPGIEILVCIYICYSIIAPILLFFSTVMLTLLYVAYLYNLNYVFGFSFDLKGRNYPRALFQIFVGIYLSEVCLLGLFIMAKTWGPLVLEVFWIVVTALAHIYMKRKFIPLFDAVPLSAIRHARGEPGYSYPTSDLGLQEIKDIADEMKGKYEQDNTHGILTPVTKDDLKKANLIPDNDGSSENGTPSNPFESGSERASLSGSNAESDSIKKLNDTVIKKSSTLSSSTKDNNESTFVPEGEKFRKFHYSDVEALRNKRPYDEDDHSKHGPEGAVPVNADAGVIYSDPAAVMKEPQAFPPDVLETNTWTRRILQFFNPRRSYPFDSVRMRFPLVFNTSIEYDEEYLSSAYTDPCVREKDPIVWCCKDPLGVSKQQIQEARSNGLDVRDDFTRYDEKGKVIFTYNPPDYEPEAKK
The following text describes a protein:
Function:
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Note=May be transiently localized in the nucleolus.
Sequence:
MEERGDSEPTPGCSGLGPGGVRGFGDGGGAPSWAPEDAWMGTHPKYLEMMELDIGDATQVYVAFLVYLDLMESKSWHEVNCVGLPELQLICLVGTEIEGEGLQTVVPTPITASLSHNRIREILKASRKLQGDPDLPMSFTLAIVESDSTIVYYKLTDGFMLPDPQNISLRR
The following text describes a protein:
Function:
Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasmic vesicle. Lysosome membrane.
Sequence:
MNTDERNFRSIYYEKCQINSVEEQKSLNKLLQDDIRNLSKLKQFCMNYTVPNNNRSYLWALVMGILPLHKASTAYVRDQRREMYEDLRRAVTVLRFTDHKQKEQPFMWLIDHKKKAQVMHTMWLIESNRLWHGNTSASLQADDMHFIEIVRTLLQIFDDNVETYWIAKGFYKYTRELKKECVKLKEQTQNILKREDLSLLNHLELLGLFDGNSTLLDNWYITCFAGIICTTHLVKIWDKVCGGSRKIVVFLFVELVKDIRSSILKQTSLADVKRLIETVKDLDGVIIVNKAIKSLQNNSSEVEYTH
The following text describes a protein:
Function:
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Prevacuolar compartment membrane; Single-pass type I membrane protein. Note=Cycles between the Golgi apparatus and the prevacuolar compartment.
Sequence:
MFFLTKILPLRGRIFPMFGCLLLIVSLITGCIASPAAEVAETVFDSKPVDFMTFKDSTNTLFLNAEFGDVYLSQDNGQSWRNGVISGQVCPIKKLIKHSFENSRVFALTECDTVYYSYDNGENWDYFTIDHPISITQLPFHFHAKNPDYVIFNNQYCSSSGTWVGKICKPDLYYTKDGFQSDPEPMPVGSSYCIFADSSEKMVVSSEEQIICISLNPNSAARPPFSHHIVYSDDWFQSIVPVQLHNFLGSDGAYGILSTGSFLVAALIDAATRKLFVYVSQDGYYWEEALKFHKGFEFDAFTILPSTEYSFFIDSLDSHPNNPTGILYSLDSESNTFVIRQMNTNRYVDGYTDFMLIDYLDGLQFVNVVENVDEIEVDPQVDKVLSSRITFDGGKTWSTVASPESSCNSMKQCSLHLFLDPHVSHASIASSKFAPGILLASGSVGDRLLSENQMDLFVSEDGGRNWTLSRDGMHLFAMSGFGSIFFASEYLDVINEVYYSLDHGQSWVTVTLDKTIVPIKLFASEDPYAEIFYLLAMTDDGEQSNYSLFSFNFGKFLPKECQFSNSESNKNDFEKWYTRYANGSPICSEMGKKEFFWRKKATSVCSVPKSITDLHGSFDACECTDEDYECNTQFISNDQGECKLLDFIGSLLCASEDLDTFQKIPYRLVPGNKCTPNKRDSHREPQTFNCDSFNEPGTEITSFLYDFDEKIVDVVYLEGTVPEENTFLIGISVNSHVYFSEDEGKTWDKFSKEEFSSVLPHAYNKNSVYMVTSKNIVYFTTNRGKNFYKFKAPSPPNQNGKSLFSFHPSRPAWLLYAGSENCEKNPFADDCRDVVFVSLDFGDTWSRLPSNLEYCSWAKAEKLVVDDTLIFCIRQNTNDPFKKELISSIDFFEYEQDEILNDVVGFMIEDEYVIVAVQDEEGTSLSLDVSINGLNFASCSFPAYLNVHPKQAYTILDSQTHSLFIHVTTNTHLGSEWGDILKSNSNGTYFMTSLANVNRDSVGYVDFERLEGIQGIALANIVSNTKELTDGGTKKLQTLITFNDGLDWSYLNLVGGEKIVPKCGKNCYLHLHGYTERNQFSDPTSTNAAVGLIIGVGSFSPFLIPYEESQTFISRDAGVTWYRIFDSPHLWAFLDSGSIIIAVESISPTNVIKYSADEGRTWQEYQFSEKSKVVVDVSTKPSGVGHQVLLLTTDDENAPISSVLIDFDALYRRTCVFDEENSEESDFVRWVPTDISGKPLCLRGRISSFYRKSIHKKCRVGSSLLVKEEVLSKCECTRADFECDYNYRRLKDGTCVLVSGLQPPDTREEQCSVDDAFEWRQPTGYKRTPLTECEGGVPLDAGTLHPCPGKEDDYYKAHPKPGGWSIFLTIIFSILLAAVAGCILYYYSRRFLKGAIRLGSDSATENPLESGISYTRGAFSSIPIFFSALYQSVRSLFIRSTPTNGEFENAAFLQNYEIDDDDEESV
The following text describes a protein:
Function:
Transcriptional activator that binds the same DNA consensus sequence as p53. Has a role in normal development to ensure proper meiotic chromosome segregation. Promotes apoptosis under conditions of cellular and genotoxic stress in response to DNA damage, hypoxia, or starvation. However, not required for DNA repair in response to UV-C or to regulate cell-cycle progression. Regulates germline apoptosis in response to DNA damage. Required for induction of ced-13 in response to DNA damage. Its pro-apoptotic activity is inhibited when bound to ape-1 in vitro (By similarity). Regulates germline proliferation by activating phg-1. Regulates DNA damage-induced apoptosis by inducing transcription of the programmed cell death activator egl-1. Negatively regulates lifespan.
Subcellular Localization:
Nucleus.
Sequence:
MNTEATDSQLSVLIKKEKIVPDSQEVDGNTTRELGDNTLDEIINGQFSPLMSQNSENELEKHLRSTPGIEGVFESLLHNEIQEPDITHLSLMSTHPSESGRQPELIKTRTRTPRIVNDGPLQQTSRSELLDLNALFDTEESALMNQSIESETTLTQFLGGSQPIDYLRERTKEEQDKRNQMRQEEKLIKKMQKAQVEKARSEMFSERNHEFEPMECDNDEEDVFRAVKEDSSNREKEEEWLTFEVKKERASKVSDFEFETVVNDGIYLWAKMKCNIPFIVKWNVSSCHKQLFLKVRLVNYMASDNIENSIRVPSNLAKCHNHRMTEEKTPRESFFYVVKSGEHWTPQINSKKDQCFVAKLAPGTTQVLFDLIFKCQRSCLDLAERRKRMCLAVFLEDENGNELLHDVIKQLLIVGYPRRDWKNFCEKRGDFKFSEKSLLVQTTNNIFADQSSLHSGPSSPEKVTDTSQMFQSTSSSSRKRAASDVKFVASAVPSSDQQSYPMRLHGCESRRMEMSFYRKFKENEDSLSNKRPRSQYGLQRQVKLSEKEYSKFVAFFAKEGENEISKYASAHCLTPAQASRLDPSDKIEKFLAFVGDESAADNFRKHGLFTMLDLDKYFQVYDSAFETIGVDSSKMEKYYDLFLHYHRVQENIRYNQPK
The following text describes a protein:
Function:
Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters. Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs.
Sequence:
MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFSWLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGVMCALGIIMALFDRTRTGKGQVIDANMVEGTAYLSSFLWKTQKSSLWEAPRGQNMLDGGAPFYMTYRTADGEFMAVGAIEPQFYELLIKGLGLKSDELPNQMSMDDWPEMKKKFADVFAKKTKAEWCQIFDGTDACVTPVLTFEEVVHHDHNKERGSFITNEEQDVSPRPAPLLLNTPAIPSFKRDPFVGEHTEEILEEFGFSREEIYQLNSDKIIESNKAGSKFWILYPTRSNIQK
The following text describes a protein:
Function:
Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity).
Subcellular Localization:
Endosome.
Sequence:
MFMNRLFGKPKQETSTLQTLDKLNETLEMLEKKENVLLKKATGEVEKAKEFSRAKNKRAAIQCLKRKRLYEQQVEQLGNFQLRIHDQMIMLEGAKATTETVDALRTGASAMKAMQKATNIDDVDKTMDEINEQTENMKQIQEALSAPFGANDFDEDELEAELDELEGAELEEQLLQPVPIHVPQGNKPARAPAQKQPTAEEDELAALQAEMAL
The following text describes a protein:
Function:
Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis (By similarity). Involved in cilium assembly.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=Associated with the pericentriolar material. Localizes to centrosome during interphase and mitosis (By similarity). Translocated from cytoplasm to discrete nuclear foci at sites of DNA damage.
Sequence:
MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGEVKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGILPGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQRKREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADMRRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHETGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENLKAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFSTTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEGEKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLETEILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSDIHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSHLPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEPTANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MVDNFLMCSWIQFASIFCAFVLLCLYPNPENDGVPGQGTSVRILPTSKYMHPDYTFWNWRDQRMSVGTQSDFNQAAMSHLASGSVSFTDVTVDFSQEEWEQLDPSQRILYMDVMLENYSNLLSVEVWKADDQVEKDPREPDKQAPSLTTPKNQPPTEERGSLFGKRLNLNTDLVSLRQVPYKYYLYGKTLMYNSDLLSSRSCVVEKGDECGGLGEPLLYLKQEKPHAGLQYSEYNGNGRSLSHTDAIFKHQKIKSLVQPFVCNYCDKAFSFKSLLVSHKRIHTGEKPYECNVCQKTFSHKANLIKHQRIHTGEKPFECPECGKAFTHQSNLIVHQRAHMAKKPYGCNECGKTFAQKFELTTHQRIHTGERPYECNECAKTFFKKSNLIIHQKIHTGEKRYECSECGKSFIQNSQLIIHRRTHTGEKPYECTECGKTFSQRSTLRLHLRIHTGEKPYECAECGKAFSRKSRLSVHQRVHMG
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MDPNCSCATGGSCTCAGSCKCKEGKYTSCKKSCCSCCPMSCAKCAQGCICKGASEKCSCCA
The following text describes a protein:
Function:
Required during maturation of the 40S ribosomal subunit in the nucleolus.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSEHRHRSGDLHQQNKGFKGGKHDSKGAIKRRAQGKIETNGARQSIKNLAIVNNKDAMRQKHQKLVKSKKNELLERKRLGLPDQVAPRVVTIIKLSESCNTKKVKEMLLQKFKLNINTGEMEMDNEETLNNKNNNNDNFTTISLTSKVRMMLLECQTMAYDQVIEFCKLSDIILFVIDANQAKLNSEAERIFTIVKAQSVPTVIEIIQNLDQTPIKKRNELKKSIQSVFHFHFPNEPKVLPMDTNDECSQVLRYIENIHVNEIIWRKVRPYMLIEKSSYIPETKVVTIDGFIRGNNLSAKQIIHIPDYGDFQIEKIELIDDPHIRKKSYYTNNNNNNSNNNNTGGGEMEQDKKINILDKVDQKDKDTLQTWNVPDPMDNEQALPTAEEMKEIEANKKKKLVPKGTSGYQSSWYLDNESDEEEENFENEDLDMNQEEMGQDKEEEMGEEEEMGEEEEEEEEGQEELEEVKESNKWKGIKHKSQITDELLKDSDDEDDDENKEEQSEDEDEDERKQLQQDEILYPDEVDTPGNVPSRIRFSKFRGLKSFRSSPWDVKENLPIDYAKIFQFHSFNQSMRASIAILDNAPAKPDMYVRIHLVNGPKQLVERNTTAITTKPEVAVGLYRYENKISLLHFSVEKHKSYEETVRSKEEVYFHFGWRKFSTSPIYSISSPNCDKQKFEKFLLPARNTMATIYGPITYPPAPLLIFNGKDCNELVATGYLSSVNPDRIICKRIILTGVIAKSISKKFVTVKDMFYYPEDINWFKKVELYTKMGRVGHIKEPLGTHGRMKCQFDGTMNQQDTVCMNLYKRVYPKWIKDDSSLLKLE
The following text describes a protein:
Function:
Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoate by hydrolytic cleavage of the five-member hydantoin ring. Catalyzes the first step of the ureide allantoin degradation followed by the sequential activity of AAH, UGLYAH and UAH which allows a complete purine breakdown without the intermediate generation of urea.
Sequence:
MEFQKRSFFFSLLPVIASILLFFLKFSLKTAPSGCSLLPHNHYWISSKRIVTQDGVISGAVEIKDGKVFSLVKEEDWHGYIRNGHIVDFGEAVVMPGLIDVHAHLDDPGRDDWEGFPSGTRAAAAGGITTLIDMPLNSEPSTVSVETLKLKMNAAKNRIFVDVGFWGGLVPDNALNATALEGFLRAGVLGLKSFMCPSGINDFPMTNITHIKEGLSVLAKFKRPLLVHAEVQEDVVGESVEDDKNDARLYSTYLKTRPPSMEETAIRNLLTVSENTRAGGPSEGAHLHIVHLSDAQSSLDLLKKAKGRGDSISIETCPHYLSFSADEIPDGDTRFKCAPPIRDADNKEKLWEALTGGDIDMLSSDHSPSLPDLKLLQEGDFLKAWGGISSLQYVLPATWTSGRKYGVTLEQIASWWSEKPAKLAGQHLKGSIAVGNYADIVAWDPESEFDLDENHSSYIKHPSISAYMGRKLSGKVLATFVRGNLVYKEGEHAPAACGSRLLAQ
The following text describes a protein:
Function:
Responsible for physiological and behavioral changes in mated female flies. May play a role in accessory protein regulation and/or in the coagulation of seminal fluid to form a mating plug.
Subcellular Localization:
Secreted.
Sequence:
MGNHQVIFLVLCTSLLFQNTIQQNVSFQLIREIDRYTPENFVLSVLNIEMILFEIHAAKAVESNNDLERSLIINFGYSEARQEVLDWGLRYKKASSAKFQMANKVAVSQKLPLSQKLRLVNEVLMTSAKKYDVTKDVRPSKLMDEWLSSHLDGVLANFVQEKKLNAGENIVAISGMTVTPLWASHFQSEINRYFVNNPGTGYASKDPTCVPMMHSLSSFETMSTDEAKGIYIPFSSANLGMLILLPRKGVTCKDILDNLNNQINVEYNDHKDVHLLLPIFKEKFDYNIAKFFNGINIEDTFKDSAFKSKAKIKINNFRVNHGIRFQPILRLEVVDDIDTGKTETFEVNRPFVFVIKDKINVYAVGRIENLDGLTDKVNCSKKYADL
The following text describes a protein:
Function:
Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.
Sequence:
MVRGGAATRARAPCLPVLQADPYGAQRREDLSRSPTAARPATTPTTQAAGAATTGEAPWCNGDHGQSPLEAPHKSVNGQPNVSSARRAVPVPEACRTLSNARHTVSTVGCTVTVTATTITTTTLAEVDTVAHRAAPRGFNLTLSNIKMKATVTVHMKKEREDPVSSYCKYSGTGADEEFYTYEATFTVPASFAPIGAVRVVNDQNTEMLLARRGKHLPRRPGPGVVQRYVIPLQLVSWIHPSHSSHDKRTFFPVTQLPSCLRVVHYSYLPSQTPEGMKRLRSSELLAIRGDGTGERKPHQRIYDYDVYNDLGNKRPVLGGEKRPYPRRCRTGRRHYKQDAASDAPSEMRATDKIYVPRDEAFTEIKDAAFIRELVYFVRGTRGLHAQVQGYERPQEPQEPSQSQPHTQAEIVGVMIGFVVDELEHLLHGAHLCEEIRRFLKFETPEIHDKDKFAWFRDEEFARQTLAGMNPLSIQLVTELRIVSKLDGPSLITKELIEEQINGVMTAEEAMSKKKLFMLDYHDMFLPFVHKLAKSHVLAHDTGYHQLVSHWLRTHGCVEPYIIAANRQLSRMHPVYQLLHPHFRYTMEINAQARQMLIDAGGIIESTFSTGRYCMELSSVVYDKFWRFVMEALPEDLIRRGMAIRREDGKLGLAIEDYPYANDGLMVWDAIKQWASDYVKCYYSCAEDIIDDQELQGWWTEVRTKGHEDKKDEPWWPVLDSHESLVQVLAAIMWVTSAHHAAVNFGQYPMAGYIPNRPTTTRKNMPPEMGGPDSKEMRAFLEEPERVLLDTFPSQYQSVVVMLVLNLLSSHSPDEEYMGTYQELVWSKEEKIKEAFDRLKSKMIDIAAQIDTGIEGFPV
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MIRSEKEFDYIKIKLASPMRILQWSHRKLPNGQFVGEVQKSETINYRTFKPEMDGLFCERIFGPSKSLECACGKYKRVRYEELTESRVRRHRMGHINLIYPVTHVWYTNSRPNYIALLLEVEQCEKRLDTGWTEFADLRDIKEKDNKDIPEYPSSEIECRNYLASPKAILNCKEFLKEKSKAKKSNIVNFYDERIKRIKLASLAYFIAEDEIAFYGLHWDLQQYRRCRELGFTGYPLKPHSKSRNRRRNTPKYLLRSTPNYLIEKLNLDQEIIKTRNFIMLCSKVLHKEQPFYNFSHWSRKWEYQRIYKLRDQSIKRIRILENLLTTGANPAWMIITILPVIPPALRPMIQLEGGRFATSDLNELYRRIITRNNRLLRLLEIDAPQLIILDTLIDNGKRGKIALSASNRPLKSLSDIIKGKHGRFRQNLLGKRVDYSGRSVIVVGPSLKLNQCGLPYEMAIELFQPFIIPSNMKVAKNLLQQNEPIINPVLEKVLANHPIFLNRAPTLHRLGIQAFQPIIVQGRAIKLHPLVCSAFNADFDGDQMAVHVPLSLEAQAECYMLMLAPYNFLSPANGEPIIMPSQDMVLGCYYLTVNNINGLLGSNHYFADLNDVILAYNQDQIEIHTSIWVRYKHKISKPSNFIKKIILNDKSYIEYYENIQIRKDENDQIIVQYLQTTTGRVLLNYIIQTTLNLKP
The following text describes a protein:
Function:
The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGDVAVESSATNVTPSKSAPFDTIPNIDSLEGTDADGGDEYATLKRLQRHLEYIQLQEEYIKDEQRSLKRELVRAQEEIKRIQSVPLVIGQFMEAIDQNTGIVQSSTGSNYVVRILSTLDREKLKPSSSVALHRHSNALVDILPPEADSSIAMLGENEKPDVTYADVGGLDMQKQEIREAVELPLTHFDLYKQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTASFIRVNGSEFVQKYLGEGPRMVRDVFRMARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFEQTSNVKVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFTTIASKMSLSPEVDLDSLIVRNEPLSGAVIAAIMQEAGLRAVRKNRYNIIQSDLEDAYAAQVKTGQEADRYALPCIQIYLTTSSNYCVTGSISTGRLCTIIGIYEVGTGPVPHERIIMD
The following text describes a protein:
Function:
A protein that aids in conversion of cob(III)alamin to cob(II)alamin and then to cob(I)alamin in the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. The latter step requires PduO. No free cob(I)alamin is released, suggesting a complex is formed with PduO that finishes conversion to adenosylcobalamin. PduS and PduO allow regeneration of the adenosylcobalamin cofactor within the BMC. Another study showed reduction of cob(II)alamin to cob(I)alamin in the absence of PduO. Both reactions require NADH. Cyanocobalamin (CN-Cbl) is not a substrate for the first reaction. Cobalamin reduction probably occurs spontaneously in the presence of free reduced flavin nucleotides, this protein may be involved in electron transfer for this reduction (Probable); The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
Miscellaneous:
MISCELLANEOUS: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate. BMCs can constitute up to 10% of total cell protein.
Subcellular Localization:
Bacterial microcompartment.
Sequence:
MSTAINSVEMSLSADEIRERVRAAGVVGAGGAGFPAHVKLQAQVEIFLVNAAECEPMLKVDQQLMWQQAARLVRGVQYAMTATGAREGVIALKEKYRRAIDALTPLLPDGIRLHILPDVYPAGDEVLTIWMATGRRVAPAALPASVGVVVNNVQTVLNIARAVEQRFPVTRRTLTVNGAVARPLTVTVPIGMSLREVLALAGGATVDDPGFINGGPMMGGLITSLDNPVTKTTGGLLVLPKSHPLIQRRMQDERTVLSVARTVCEQCRLCTDLCPRHLIGHELSPHLLVRAVNFHQAATPQLLLSALTCSECNVCESVACPVGISPMRINRMLKRELRAQNQRYEGPLNPADEMAKYRLVPVKRLIAKLGLSPWYQEAPLVEEEPSVEKVTLQLRQHIGASAVANVAVGERVTRGQCVADVPPGALGAPIHASIDGVVSAISEQAITVVRG
The following text describes a protein:
Function:
Specifically methylates the adenine in position 1618 of 23S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MPRPTSPHPDAERKSASPLHPRNRHLGRYDFPRLIAGSPELERFVILNPYGRQSIDFADPAAVKAFNRALLQQFYDVREWDIPDGYLCPPIPGRADYLHYLADLLGASHDGLIPRGPGLRALDVGTGANCIYPLLGHHEYGWRFVGADIDPQSLASAAAILAANPRFAAAIELRRQPDRRQIFQGLIGVDERFDMTLCNPPFHASLDEATRGSRRKWKNLGKLDPTRTLPLLNFGGQGAELYCEGGEAAFLAGMAEESRAFATQVFWFTTLVSKASNLPNLQERLKTLGASDIRVVDMAQGQKQSRFVAWTYLDKKQRRAWRKERWTAALLEPLGE
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MDNTAKTFVIPNELCRRAGVAASWLSVNEFGVFGHQKTPKVDKPSHFAPSDASVFQLRPDIILFKPILRKLVNEANGTFLTLQALVATEGDHKAELLKLSRQYRSIIRACLENLQDEVMRADGDYREELQNYITIFYSVECIWHLCEILFVDAVPGNIVLPHLLDWIRFHFPKYDRNAASMLAGDLGGLESHPDYWETVIGSLLQGRVKVVRALLKLHSEAESQPFRIVDQCLRAMPVYNMFSGTSIAEFNLQWNHWVVDVQSKIDAKMFISCYNLNLIMKLTVGNEIAWGEIQQYCETWYEMLAAWLFFTQPTVKSFELGQFAKQCITKMSIGNRIKHLDRMLLAAMEFDILQVIKEIQNMTDSGWFVSHLTDLLYHSGRLSDTTIETIENFHPDKLRESFLIDYGSLLMGHKSLWQVGLSYLDHCPSDGPEVTKLLLARLPLNSEMRAEKIVREALNRNLTETAQSICKVQGMACKNRGRLGHALAWALKSQDGTFVSFLSNKFLREYAESGDLNSIDLLDNLGSCILASDRLMFLGKYYEFQKLYQANEYKEAANLLVSLLESKIIPNFFWSILLTDAIPLLECEKMVFSSTDTYIIMQCLEEQEKTKDLKDKLPILRLSATRNLARALVHEAQLK