lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds.
Sequence:
MAHGTMDTAQLAAVALSHTNPHLATLKEDNMYHIGFSTRDDLRHLFGDVQVVVTGGSPTRMQHFAEMVLLELDLPLPFGSQLHDICSTDRYSMYKAGPVLCVSHGMGQPSCAIMLNELVKLLAHAGHECGNMTFIRLGTSGGLGVTPGSVVLSTQVYDGLLRASHESFILGQRVERDTKLDEALSDAIAQAAPSEINIVRGATMSTSDFFEGQGRLDGAICSFGEEDKMRFLQQAAGVGVVNIEMEALVFSSFCHTVGVPAAVVCATLVVRNFFNGAPSSLLCPLFLLFVLLSNALVCVCVCVCVCVCVCVCVCVCVCVCVCVCVCVLMEEDRLQGDQLSEDSTMIKSFSLNAQRVLLAYLKARFGK
The following text describes a protein:
Function:
Receptor for the pro-inflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MSLVLLSLAALCCGAVPPEPTIQCGSEPGPSPEWMVRHTLTPGDLRDLRVETIKSNVDLEDSPILMNISWILRADASIRLLKATKICVMGKSHFQSYSCIRCNYTQAFQTQTRPSGGKWTFSYVGFPVELNTVYFIGAHNIPNANMNEDGPSMAVNFTSPGCLDHVMKYKKKCIEAGSLWKPNITACKRSANTVEVNFTTSPLGDRYMALIQSTAVIGTSYVSEKELTRTSVVVHVTGESEGAVVQLTPYFHTCGNDCIRQRGTVVQCPQTGVSSPQDHDRSVLGGWLPLLLSALLVATWVLVAGIYLIWRHERIKKTSFSTTTLLPSIKVLVVYPSEICFHHTVCYFTEFLQNRCRSEVILEKWQKKKIAEMGPVQWLTTQKEAADKVIFLLSNGNTTCDGNCDEKEGGPCESSRDLFHLAFNLFCSDLRSQAHLHKYVVVYFREGDIADSYRALSVCPTYRLTKDATGFCAELLRAKQHVSVGRRSRTCHYSCCSL
The following text describes a protein:
Function:
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MTMDRPPAPPPPSSDPRDARRHDPEADATSEPDSSRGGMEPPAEPQLLLNGAAKEAGRPSPGPPAAAVPVIELVRRGGSLDIKSREAAGEAMQRAPGAEPCRAAEAACEARMVQLSPPALPLQPPGRAMLYNLGQPLGTIGSGFFGEPDSFSMYGSNRVKRRPSPYEMEITDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKLLNDQEEEGNQRGKVNKDSGIVQEDLLQDMLSPNSSCGSSLDGAASPDSFTEEHDTLDSKHARNLHHAILPVEGSAQR
The following text describes a protein:
Function:
Promotes dephosphorylation of transcriptional activator STAT3 by interacting with both STAT3 and protein phosphatase PTPN2. This promotes interaction of PTPN2 with STAT3 and mediates STAT3 dephosphorylation by PTPN2, leading to negative regulation of STAT3 transcriptional activator activity. May be required for spermiogenesis or sperm function.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Localizes to both nucleus and cytoplasm but located predominantly in the nucleus. Detected in the sperm acrosome prior to the acrosome reaction and is likely to be released from acrosome-reacted sperm.
Sequence:
MRDRRGSLGTCLAQVQQARGGDSNKLSYSLKKRMPMEGLWPADAPSWMNKPVVDGNSQSEALSLEMRKDPSGAGPWLHGGGPVLPYVKESVRRNPASAATRSTAVGLLPAPTECFAQVACSGVEALERDWLGGGARATDGHRGQCPKGEPRVSRLLCHQKLPEMGSFQDDPPNALPKGLGSELEPSCLHSVLSATLHACPEVLLNDETKRVFLDRLKPMFSKQTMEFKKMLKNTSDGLQITLGLLALQPFELANSLCHS
The following text describes a protein:
Function:
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MIGFIHLSYFLAAILFLLGLKKMSHPRTARPGIVWAGVGMLLAVLVTFLLIKNNLDLTNFILIISAMVIGTVLAWVSGKRVAMTAMPQMIALYNGMGGGAAAAIAASETLSSSHHLLNLTLALIGGLIGMIAFSGSLIAFAKLQGIIRKTITLPLHNIIMAIFGLIILGLLGVLLFYSEQQALLAVYFGLLFLYGIFMTLPIGGANMPVVISLFNAMTGLAVAFEGFVLANPLMMVAGIIVGASGTLLTLLMAKAINQSVTAILFTPHHDGPITTQGIEGTLKPINATDAGVMLAYAQKIIIVPGYGMAVAQAQNKIWELAKLLMERQIQVKFAIHPVAGRMPGHMNVLLAEAGVPYDFVFTMDEINEEFAATDVAMVIGANDIVNPIASQSKESPLYGLPVLHVERAKNVIVIKRGQGRGFSGVENSLFYMDHTRMLYGNAQPVISELIQAVKQY
The following text describes a protein:
Function:
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Sequence:
MAKSAAYSNTKSFSSIPIFLFVVSLTVLLYTSTFAEAGEGDASAFAKKTISSHSIVIFSKSYCPYCKKAKAVFKELKQKPYVVELDERDDGWSIQDALSEIVGRRTVPQVFINGKHIGGSDDTVEAYENGELAKLLGLSAKKDDL
The following text describes a protein:
Function:
Probable splicing factor involved in constitutive and/or alternative splicing events. May bridge the 5' and 3' components of the spliceosome.
Miscellaneous:
MISCELLANEOUS: The splicing patterns of the pre-mRNA are similar throughout the developmental period, but change in response to various types of stress treatment.
Subcellular Localization:
Nucleus speckle. Note=The phosphorylation status has no effect on the localization.
Sequence:
MGKREIHFTPVGRQVQRVLEYPLRLENRSPMSYSRRSRYSPSLSPYDKRRGRSVSRSLSRSPTRSVSSDAENPGNSLYVTGLSHRVTERDLEDHFAKEGKVTDVHLVLDPWTRESRGFGFISMKSVGDANRCIRSLDHSVLQGRVITVEKARRRRGRTPTPGKYLGLRTARGRHKSPSYSPRRSVSCSRSRSRSYSSDRGRSYSPSYGRRGRSSSYSPFYRRRRFYSPSRSPSPDDRYNRRRDRSYSPYYRRRDRSRSYSRNCRARDRSPYYMRRYRSRSRSYSPRYRARDRSCSPYYRGRDRSYSPHYQGRDRSYSPESRYYRRHRSVSGSVSPGGRSMSRSISPRKGRKESRSKSRRHDRQSSMCHSRSARSSTSRSVSP
The following text describes a protein:
Function:
Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Involved in neuronal progenitor cell division and differentiation. Involved in the migration of precerebellar neurons (By similarity). Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm. Cell junction, tight junction. Golgi apparatus. Cytoplasm, cytoskeleton, spindle. Cytoplasmic vesicle. Note=Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton (By similarity). Localizes to the mitotic spindle in mitotic cells, and to tight junctions in interphase cells.
Domain:
The DH (DBL-homology) domain promotes tyrosine phosphorylation of RIPK2 (By similarity). The DH (DBL-homology) domain interacts with and promotes loading of GTP on RhoA; The PH domain has no affinity for phosphoinositides suggesting that it does not interact directly with membranes; The phorbol-ester/DAG-type zinc-finger and the C-terminal coiled-coil domains (606-986) are both important for association with microtubules.
Sequence:
MSRIESLTRARTERSRELASKNREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNSTALQSVSLRSKTTPRERPSSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTNIAGHFSDESPLGLRRILSQSTDSLNMRNRALSVESLIDEGAEVIYSELMSDFETDERDFAADSWSLAVDSSFLQQQKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELQLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLADLLISQFSGPSAERMRKAYSEFCSRHTKALKLYKELYARDKRFQQFIRKVTRSAVLKRHGVQECILLVTQRITKYPVLINRILQHSHGTDEERQDLTTALGLVKELLSNVDQDVHELEKGARLQEIYHRMDPRAQAPVPSKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLMLLMTDVLVFLQEKDQKYIFPALDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWVRVIQQSVRVCPSREDFPLIETEDEAYLRRIKMELQQKDKALVELLREKVGLFAEMTHFQVEEDSGGVALPALPRGLFRSESLECPRGERLLQDAIREVEGLKDLLVGPGVELLLTPRDPALLVDPDSGGSTSPGVTANGEARNFNGSIELCRTDSDSSQKDRNGNQLRAPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLARANSRDGEAGRVGPAPVAPDKQATELALLQRQHALLQEELRRCRRLGEERATEAGNLEARLRESEQARALLEREAEEARRQLAILGQSEPPPAEAPWARRPLDPRRRSLPAGDALYLSFTPPQPSRGHDRLDLSVTIRSVHRPFEDRERQELGSPEERLQDSSDPDTGSEEEGGGRLSPPHSPRDFTRMQDIPEETESRDGEPMVSES
The following text describes a protein:
Function:
Involved in the export of mRNA from the nucleus to the cytoplasm.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes at both the nuclear and cytoplasmic site of the pores. Shuttles between the nucleus and the cytoplasm.
Domain:
The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus; The NTF2 domain heterodimerizes with MTR2. The formation of this heterodimer is essential for mRNA export and binds to all of the nucleoporin-FG-repeats; The RNA-binding domain is conserved in most NXF proteins but may be absent in yeasts.
Sequence:
MLRRKRERRNAVKENEMVIDTPLEKRRTPGKPRATREPPISVVITGHSKGSEDDLISFVWRKVKVRLMNISYSPASVTAVVKSQDFSRLNGLNGAAFAGDHLAIRRVDGASNVTQDYRKAKTKRSFRSVSAPSLSALATQAQRNVSKTLPQSTNETIEKLRQFLQTRYQPATKFLDLGNLQQDPLLKQMGILAEASTKSKMFPALMKVASLNFPDVISVSLSDNNLQSVTAVTTLAQTWPKLLNLSLANNRITSLSDLDPWSPKTKLPELQELVLVGNPIVTTFANRAMDYQREMVSRFPKLRLLDGNSINSEIIASQSTVPFPVYQSFFDKVETEQIVNSFLAAFFKGWDENRSALVNQLYSPNATFSISLNASNVRTNFSQKTDTKKWGAYKMKSRNLLYSQSQKESKSRLFNGHEEISNAVKSLPATAHDLSDRSQWVFDGWNLVLPSVGAAIKIVVHGQFEEPQNKRLLRSFDRTLLILPGGSTGILIINDLLVIRSFAGSLGWLPGQSSVRTSNNAMSASASKPSDIVQPRPEQAMLDTRQQIVLKIKAETGLNDYYAHMCCEQNNWDYNSALASFLELKSRNVIPAEAFS
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLNVRGLLSIITPLIIFFIQIIVDGVESWRHIGKSLYVVFCFFTGRSHLSYPPGLTALRRRKAMFVRHRRSGNSEGMRASSSGLSASEAYNISFDVTDESEAASGRDDGEKRSDGSVSENCSESNIGSDCWVPRLVRGHFRGDVTLLLQNPRTRKLVSPCYHLCYSESLYHLVCNVVGPIQPPTISGLPGRHTAPQWPPHASSRSAFRHGLRDDDITLTTDEYSSSASPQQGTLGARARNIRVLSGGVAPTGITVSSRIIPGVTSVVYRRESSKRVDFNRKVEPRTQPQPIASITAHHVLSYQATRQKVLIVDLDETLCFVSTNVNASCQPPSFSEVIPTASGAELFHVWERPYVRLFIQTVAKLFNLVLFTSSTKPYADSILRRLDPDHRIGRRYYRQHCRQVRRFAVNQLVTQTDASEIFTPRESNPGNSSDCRTPSSSSATITDARPAAPLRSSFYASTPERGGQAVGASSGKPCCLGDMILVKDIRILKVPPELMIMIDNSEECVSANRDNALLIPPFAPPTSPDAANGDTRDGVLLALMPLLEALLVVPDVRSVLRHGRLGS
The following text describes a protein:
Function:
Promotes cell proliferation. Plays a role in tooth germ growth. Plays a role in the control of enamel mineralization. Binds the AMBN promoter.
Subcellular Localization:
Nucleus.
Sequence:
MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYEPWFRPTHPGAEDGSWWDLHPGTSWMDLPHTQGALTSPGHPGALQAGLGGYVGDHQLCAPPPHPHPHHLLPAAGGQHLLGPPDGAKALEAAAPESQGLDSSLDGAARPKGSRRSVPRSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAAGAAPGEGKAGGAVEPPGSKGKREAEGSAAPSN
The following text describes a protein:
Function:
May play a role in the ER-associated protein degradation pathway (ERAD) possibly via its interaction with ER-localized proteins ubxn-4 and cdc-48.1 and/or cdc48.2, providing a link between the polyubiquitinated ERAD substrates and the proteasome. Also plays an important role in the regulation of other protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS) and autophagy (By similarity). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (By similarity). Collaborates with POST (F36D4.5) in the export of ubiquitinated proteins from the nucleus to the cytoplasm. Also acts as a regulator of DNA repair by inhibiting homologous recombination repair, thereby redirecting double-strand break repair toward non-homologous end joining (NHEJ).
Sequence:
MATESALIKVHVKSPSNKYDVEIAADASVSELKDKVLVFVPTANKEQVCIIYTGKILKDEETLTQHKIADGHTVHLVIRNQARPTPAPAAATPTASSAPSSNPTPSSQPNPTNNPFAAMGGMGSPADILNNPDAMRSVMDNPITQQLLGNPEFMRTIIQSNPQFQALIERNPEVGHILNDPNVMRQTMEMIRNPNMFQEMMRNHDQAIRNLQGIPGGEAALERLYNDVQEPLLNSATNSLSGNPFASLRGDQSSEPRVDRAGQENNEALPNPWASNANQATNNQSNNRSADFNSLLDSPGISSLMEQMMSNPSMQASMFSPEVINSIRQNMSNNPGLIDSIVGQIPSARDNPQISEGIRRSFPQMLNMMSDPSVMEAMRNPRVSEAFRQIQEGFSTLRREAPQLLNLFQAGAMGGGAFGSDANASSAGANSANGLADLFNSMNMGGGRPSSTAAPVNPEQTYASQLEQLQSMGFSDRARNVAALTATFGDLNAAVERLLNSP
The following text describes a protein:
Function:
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.
Subcellular Localization:
Nucleus.
Sequence:
MDHHQYHHHDQYQHQMMTSTNNNSYNTIVTTQPPPTTTTMDSTTATTMIMDDEKKLMTTMSTRPQEPRNCPRCNSSNTKFCYYNNYSLAQPRYLCKSCRRYWTEGGSLRNVPVGGGSRKNKKLPFPNSSTSSSTKNLPDLNPPFVFTSSASSSNPSKTHQNNNDLSLSFSSPMQDKRAQGHYGHFSEQVVTGGQNCLFQAPMGMIQFRQEYDHEHPKKNLGFSLDRNEEEIGNHDNFVVNEEGSKMMYPYGDHEDRQQHHHVRHDDGNKKREGGSSNELWSGIILGGDSGGPTW
The following text describes a protein:
Function:
Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MTQQLVKFIVNELNQPPFNLNLTNITFNALHPPQLLQLLSDVLCEIESKTRIDINDEPVDALALRLLTSLQIFKFKPETEDPNEFREGLIAGRPETINPILNWLLQRREDLKKRAYLSRYLVKIDIAPEMRSDSDVIDLYEQYEFLIEEFKQRHKQFDTSQAVNDTVSDLRKDLQSMEDDREVLIRRIERTQRKVSFLNNGFPLLFLILTYFTYCKVEGVANYNQLLSMAKKLRAEKEKSREFQTQKDDQKSYLSHLEARRQRLTHQLMDMRQSKVNASGQSLIQRAEDAIRVNQYMINEKLTKETQQITASIALMEKVLAAPNPTSADLQLVVQKSDELRSQIAQLTEKRALQNDPIEDGMALYRQQSLIMSRKKEACAERLNHVIQEMTALEAQLQIINVNIIKAKKQQLGENSDALLTGEQFKAYVSDLRIKSNVYKQRRAELNDLKAEYGILSRTLEILRAQEGALSDSLDRIETQQGVRGFRETRDLLERISDEKANTDEEKGRTLEEMSNLVRLLNSKINDKKVALAPLLRELRPLRQTYQESLPEYEAKKKEYDAQVQLIEDTISSIVNVNRLILVRLAVKSGLENEIVTLEERCRQLEANLTKNEKYLQRATDEMKLYVSGVQQQQTERGKSVRDQLQHKIAEQEKLNAQLRQDQKQLRDNLPHMEQQIKYGRMGYSGKTNTGKSIN
The following text describes a protein:
Function:
May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses.
Subcellular Localization:
Cytoplasm. Presynaptic cell membrane; Peripheral membrane protein.
Sequence:
MVANFFKSLILPYIHKLCKGMFTKKLGNTNKNKEYCQQKKDQDFPTAGQTKSPKFSYTFKSTVKKIAKCSSTHNLSTEEDEASKEFSLSPTFSYRVAIANGLQKNAKVTNSDNEDLLQELSSIESSYSESLNELRSSTENQAQSTHTMPVRRNRKSSSSLAPSEGSSDGERTLHGLKLGALRKLRKWKKSQECVSSDSELSTMKKSWGIRSKSLDRTVRNPKTNALEPGFSSSGCISQTHDVMEMIFKELQGISQIETELSELRGHVNALKHSIDEISSSVEVVQSEIEQLRTGFVQSRRETRDIHDYIKHLGHMGSKASLRFLNVPEERFEYVESVVYQILIEKMGFSDAPNAIKIEFAQRIGHQRDCPNAKPRPILVYFETPQQRDSVLKKSYKLKGTGIGISTDILTHDIRERKEKGIPSSQTYESMDIKLSTPEPKIKKNNWQSPDDSDEDLESDLNRNSYAVLSKSELLTKGSTSKPSSKSHSARSKNKTANSSRISNKSDYDKISSQLPESDILEKQTTTHYADATPLWHSQSDFFTAKLSRSESDFSKLCQSYSEDFSENQFFTRTNGSSLLSSSDRELWQRKQEGTATVYDSPKDQHLNGSVQGIQGQTEIENTETVDSGMSNGMVCASGDRSHYSDSQLSLHEDLSPWKEWNQVEQGADLGLDSSTQEGFDYETNSLFDQQLGVYNKDLEYLGKCHSDLQDDSESYDLTQDDNSSPCPGLDNEPQGQWVGQYDSYQGANSNELYQNQNQLSMMYRSQSELQSDDSEDAPPKSWHSRLSIDLSDKTFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGSSLMGRFRTLSQSTANESSTTLDSDVYTEPYYYKAEDEEDYTEPVADNETDYVEVMEQVLAKLENRTSITETDEQMQAYDHLSYETPYETPQDEGYDGPADDMVSEEGLEPLNETSAEMEIREDENQNIPEQPVEITKPKRIRPSFKEAALRAYKKQMAELEEKILAGDSSSVDEKARIVSGNDLDASKFSALQLCGGAGGGLYGIDSMPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIREKNRPEVFEVIQEMFQISKEDFVQFTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSNGGVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCPGVPAVMSTLLANINAFYAHTTVSTNVQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYRENFPASNTERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVRACLDSTYKYIFDNCHELYSQLTDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQELNMGKISAEIMWTLFALDMKYALEEHENQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKDAVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSDHALFSCSVVDVFAQLNQSFEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFSSHCDKENVPCILMNNIQQLRVQLEKMFESMGGKELDSEASTILKELQVKLSGVLDELSVTYGESFQVIIEECIKQMSFELNQMRANGNTTSNKNSAAMDAEIVLRSLMDFLDKTLSLSAKICEKTVLKRVLKELWKLVLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDARGLTPRQCAIMEVVLATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQSRSSKDAVGQISVHVDITATPGTGDHKVTVKVIAINDLNWQTTAMFRPFVEVCILGPNLGDKKRKQGTKTKSNTWSPKYNETFQFILGKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEKGSYGAWYPLLKNISMDETGLTILRILSQRTSDDVAKEFVRLKSETRSTEESA
The following text describes a protein:
Function:
Probable neuronal cell surface protein thought to be involved in cell-cell-interactions (Probable). Confers protection against oxidative stress. Plays a role in protecting dopaminergic neurons against oxidative stress-induced neurodegeneration.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MFTGTIFNSLFTLPLVISQFVPPPTRPVDLWDPFKTTTTPFPHGGVNQGLNRDEVVVRLPLGDIVGKEVHLHNLPWTIHKDPTEELPKDGTHFDPNPLKPKNNITVFTFLGVPYAEPPTSQRRFKPPQQLTVFPGKQPYLAFNYAASCAQDVEKSPSPFVDHPYPFMVDEDCLYLNIFSPDISKNAQTTYPVIVFFHGGNFQTGSANEWPAHGLASRGMVVVTVNYRLGAFGFMSMGDSETGNYGLQDQRLALEFVKNNIVTFGGDPQAVTVVGHDAGAASIGFHMQSPYSRHLFRSAATMSGAEVSYHSYIGKTALAFNNTMKLGRYAGCTQAVAQHRWDCILTRSTGDIIDATRNIPIEYNRYLFMPTVDGKYLPGNPLWTLVNAPSGETSIMSPVPMLIGMNAQDGSEVVLEDRRLGEFSQFNDVDHEYLKSYSLEYCYRHNYSMNREATADAILSKYTFWPDRAAAWAIKENFIQFATDAYYTAPMQLSSHLHSSSGSRVFQYVNNYNFSRQHPNLLFIPDWMGVCRDCDLYLMFGYPFLPDELRPIGLRGINFTDTDRNASRTFSNIIRRFSYHQNPNFQFDGSWAAYEPRRHWYINFNYTHEEDWKIPGTLARDYRYQDVAFWNEYIPALVNYMTTTFSPENVAYRREIMVFKWITGVNVIIIALLIVLAGAFGYMVWGNKEDEEAAYKAENHQLVEYRDTGHSVSDATISSRTRSPRSRITNL
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MDISACDTNEGLEHKMKKRKQEQFDDASEGNNTGSVCSGFEFASSMDKILFEKDPSPDATLVMCSKLESETGKNLPEICNLKGNVHEKEHNDDEKLSKDTDTENENINGSYNLILNAAEVKQNVAGYSVEMEEPSSMNAYKEDSGISEDPGGLRGHEVSDQGNIDTVAQELSKEMIDVKKDVHSREKLSDPDYPLPCNELEYDGDGSLKSLDVEQINDTFGNNASEKIVEGPVEEASVCCSFGEHDDEASTIKELIMSTPSCVPPGLENAETAKEEVVCFTDSGETSSVVNAMAEEETPPLVLDTSEKGDSIGSTTKKLLVLDVNGLLADFICYVPPGYKPDIIIRQKAVFKRPFCDDFIKFCFERFEVGVWSSRTRRNVDMVIDFLMRDYREKLLFCWDQSHCTDTTFSTVENKHKPLVLKEIKKLWKYLKPREFNASNTLLLDDSPHKALCNPANTAIFPVTYRFRDTDDTSLGPGGDLRVFLEGLSMAENVQKYVEQNRFGQRPITEKNASWKFYRRIIYFVERKNDQENNNSFQWN
The following text describes a protein:
Function:
Putative aryl-alcohol dehydrogenase.
Sequence:
MVLVKQVRLGNSGLKISPIVIGCMSYGSKKWADWVIEDKTQIFKIMKHCYDKGLRTFDTADFYSNGLSERIIKEFLEYYSIKRETVVIMTKIYFPVDETLDLHHNFTLNEFEELDLSNQRGLSRKHIIAGVENSVKRLGTYIDLLQIHRLDHETPMKEIMKALNDVVEAGHVRYIGASSMLATEFAELQFTADKYGWFQFISSQSYYNLLYREDERELIPFAKRHNIGLLPWSPNARGMLTRPLNQSTDRIKSDPTFKSLHLDNLEEEQKEIINRVEKVSKDKKVSMAMLSIAWVLHKGCHPIVGLNTTARVDEAIAALQVTLTEEEIKYLEEPYKPQRQRC
The following text describes a protein:
Function:
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MKVGIDAGGTLIKIVQEQDNQRTFKTELTKNIDQVVEWLNQQQIEKLCLTGGNAGVIAENINIPAQIFVEFDAASQGLGILLKEQGHDLADYIFANVGTGTSLHYFDGQSQRRVGGIGTGGGMIQGLGYLLSQITDYKQLTDMAQHGDRNTIDLKVRHIYKDTEPPIPGDLTAANFGHVLHHLDADFTPSNKLAAVIGVVGEVVTTMAITVAREFKTENIVYIGSSFHNNALLRKVVEDYTVLRGCKPYYVENGAFSGAIGALYLEK
The following text describes a protein:
Function:
Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYTILLIGIGGFIGAVLRYSLSGWVQNSFVNFPLGTLVVNIVGSFFLGLVMYLSEYQGLFSEETRILLTIGLLGAFTTLSTFSYESFRLLESSKLMQLTMNIVATVLFSIFAVYLGKISALNLAAYLRGIK
The following text describes a protein:
Function:
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Sequence:
MKPYQRQFIEFALSKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLGRFYAEALVDSGIEFDLLFGPAYKGIPIATTTAVALAEHHDLDLPYCFNRKEAKDHGEGGNLVGSALQGRVMLVDDVITAGTAIRESMEIIQANGATLAGVLISLDRQERGRGEISAIQEVERDYNCKVISIITLKDLIAYLEEKPEMAEHLAAVKAYREEFGV
The following text describes a protein:
Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.
Sequence:
MTTIVSMSDYNTTQALAVPETHHVRTVQPGANGTNGSSGCTEAYLGPQYSLEIQVLLSSFLALVILLTIVGNILVISTVALFRSLRSLTNYFVVSLAVADLLVGVIVMTLGTQYEVSGRWRHGEIFCLIFTSMDISLTTCSIMHLSCIAFDRYYAICHPFKYPTKMSHRKMVLMIAMCWVVPVIMAYVPIMNRWNTIGIEPVVEDTKCALGPESCVFLVNKEFSLIASTLSFYLPAVMMTLAYYQVYRAARRQMQQIISLERSMNNNENMRREKKAAKTLGIIMGCFLVCWMPFFVANIVEPLCGYCITRSCDLCLKFFLWLGYINSTLNPMIYAFFNRSFRRAFKRILSCSSCCDLDNRDFDPAVSTALQRRTSTRHQNGEAVNNT
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MASRLPPIALLLVLAGLTSPAAAFNITRLLGEFPDFTTFNNLLSQAKLADDINRRQTITVLAVDNGAAGGISSLPSDVQRKVLSMHVVLDYYDTAKLGAIKNHTTLLTTMFQSSGQATDRMGFLNFTKRSDGTMVFGSAEPGAPKNSQMVKSVASRPYNISVLQVSAPIVPPGVGGSADAGAPPPHKATALAPAPAAKGKKGAPSPKDEETPAPAPSDDDGGADAPDADAPGPAADGPAADGPTADGPGADGPAADAPAHKKSSDDAADAPEGSAAGRVVAGAGLGIVALLMAII
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLRTPTVSALVRNVAVRAAKPTMAVRAASTMPISNPTLANIEKRWEQMPMQEQAELWMALRDRMKGNWADLTLQEKKAAYYIAFGPHGPRALPPPGEQKKVLAYTVAGVFLSFVIFATMRAFAKPPPATMTKEWQEATNEFLKAQKSDPLTGLTSEGYNGKGHVQSPSASA
The following text describes a protein:
Function:
Amino acid transporter involved in vacuolar uptake of basic amino acids for storage.
Miscellaneous:
MISCELLANEOUS: C-terminal GFP or HA(3) tagging interferes with activity.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MPTHSLNQKRSLLYPSIDNGSVPDSSFLSQSFRDTNDIHLLSARLASVEVDPETLPSNSPETNDDVSNYDYMSISSYQRAHSLASTSRNDFNYRPSEINETRPLLPEREEHSSQLPPAQNQVLPFQSLNAPSKKLRGRISLSKIYQFFFDDKGPILFILNIPAVIIGLLLNILDALSYGLILFPISDPLFKNLGADGLAIYYVSCVVSQLVYSLGGSFFKGSVGSEMIEVIPFFHQIAFTILNRVGEDNPKSVIATTILAYCLSSILTGLVFFILGILRLGRLIEFFPRHILLGCIGGVGSFLVLTAVEVSSRLEGSVSFNWASLSALFQPMTFAKWSIPLFLSSALEFAQQRWPHPFLIPSFFVIAPAIFYVLVWAIPGMSLEYLRETGWVFSSTETNVPWYHFYSLFSLRDTDWSALLATVPEMCALTFFGILHVPINVPALAISLGLDFVDTDKELIAHGVSNTLSGAVGSIQNYMTYTNSLMFIRSGGNNRLAGIMLALATVALLVIGPGIIAYIPVWTVGCLIYLLGIELLKESLWDPIGITTKIEYFTICAIVFTMTVVDFVVGIVIGIIMACVFFVIQASSRSALRGIYSGGIVRSTVRRPMNQQRFLNEIGRQIQVCKLSGFLFFGTINGVEKNIAGLIEELNVSNNPLRFLIIDFSLVNGADFSVVQAFLRIRRMLATMNVQLCVCGLDETRSSFKTLTTMCFGGDDNCGCQVFEDVNSSLEYCENMLLDDYDVYRTKLLHKAGYSHTLAVPGKHKQNISMAETFSPSPRHDLLRQVAMSSVKAETKELSKFEKYAKYEQPFPLLMQVFGEITTKREDFWLGLCPFFKKAFLRKGDLLWRKGDTPSKLVILETGMVKASYQMDRESLSENITCLCVVGELPFFSKTCYNATVVAELDSAVWILDREGWETMLKSSDKAEVIENEMLYLTLKMTRDKFNVFTNFALNLYR