lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAVIKEKAECCTLLVDELYGQLPARVYATLFQRGKLSVRLISQFSKLSARQVKNGLCVLQQHNLLFYSVDANSGEAEYSVNHEYAYNLVRTGKILEMVDNSYGPAGRDVMQNLLLLGQTRISDLVAAYQAKINEVNNDDAWLNDKKPELAIKSKAQLNSVLCRLIEAELIDVIHSKTFQSAHEIEKQVHREVMDVYFSNGIKGTKAKIEFEQRVAEGLRKVREESKTLKRKLAQNGGASKRRKLAVGNETNGAPEEEEDLDPALDPRQVIRINYEKCIVELRSRRLVQYVNETLGETTGYVYGQLLKQLTKNISRCKSDPLIDALTPEEKVTPSVTTNEILDKVKTSIDLTLGIGKIPSKSISKSAAERLTPLAPKDKIPFMNQDDSDDDEEDGDYSDSDEEMDTKKENGDAPVARMSRPEQLRQHLLLLAEGHPGFVRHCGEDEWTVDFKPLMENLRATELDSIIEQTSGRQGLRLIRILRTKGKLGEQALQSLSLMRKVDLQQKMLEMRLVGFAHTQEVPRDNKADPKKSIFLWYCDTEQAYSSLIAKCYATMVHCLQVLEVRRQKDKDVLSLAKRTNVKGKEKDMMRDESYARFAKFLKDERLLMAEMMRIDDTLALLQDY
The following text describes a protein:
Function:
Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
Subcellular Localization:
Nucleus.
Sequence:
MAETGPNTPQDLSDMVEAMMRGLQNKFQAMSDQIVSRMEEMGTRIDDLEKNVADLMTQAGMDESEAHFKQDK
The following text describes a protein:
Function:
Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MFSLEAWIGLRYLRAKKRNGFMSFITMVSIAGIALGVTALIVVLSVMNGFQKEIRGQLLNVAPHAEIGYIDNTDTDWRNLLRFTENRKGILAAAPYVSNQALLANAGEIRGVQMRGILPSEERKVVEYGDKMPAGKFEDLIPGEFDIILGVGLAEALGAEVGNKVTVITPEGNVTPAGVVPRLKQFTVVGLVKTGVYEVDNSLAMTHIQDARVLYRLDKEVAGLRLKLADPQNAPALTATLIPEAQRDAVWVRDWTYSNRSYFEAVELEKRMMFIILTLIIAVAAFNLVSSLVMAVTEKQADIAILRTLGLSPAGVMKIFMVQGAFSGFFGTLAGVVCGVLLGWNVGRVVAFFENLLGVHLINSQVYFIDYLPSDVDMGDVALIACISLGLSFVATLYPSRRASKTQPAEALRYE
The following text describes a protein:
Function:
Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 (By similarity). In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MRISKPHLRITSIQCYVCLLLNTHFLTEAGIRVFILGCISAGIPKTEANWEDVRKDLQKIENLIQSLHMDATLYTESDVHPRCKVTAMNCFLLELEVISHESRDGDIEETVKNLILLANSSLSSNGNITESGCKVCEELEEKNITEFLESFKHIVQMFINPP
The following text describes a protein:
Function:
Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides. Mediates threonyl dipeptide catabolism in a tissue-specific way. Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism. Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis. Plays a role in the regulation of cell cycle arrest and apoptosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MAHLQALFQHVDQNQDTYVQRLADWVSVQSVSAWPEKRGEIRRMMEMAAKDIERLGGTVELVDVGTQKLSSGELLPLPPIILGSLGSDPAKKTVCIYGHLDVQPASVEDGWDTEPFTLVERDGKLYGRGSTDDKGPVLAWLNCIEAYQKIKQELPINIKFCLEGMEESGSEGLDELVFSQKDSFLKDVDYVCISDNYWLGKTKPCITYGLRGICYFFMEVEGSDKDLHSGVFGGSVHEAMTDLIALMGSLVDKKGKILVPGIHDGVAPLTKEEEELYGAIEFDLEEYSKDVGVRKLLHKTKEEILMHRWRYPSLSLHGIEGAFSDVGAKTVIPRKVTGKFSIRLVPDMDPKVVEKQVIDYVQKKFQELESPNKLNVYSGHGAKAWVSDFNHPHYMAGRKAMKTVFGVEPDLTREGGSIPVTLTFQEATGRNVMLLPLGSSDDGAHSQNEKINRSNYVEGIKMLGAYFHEVSQLE
The following text describes a protein:
Function:
Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III. Can also oxidize protoporphyrinogen IX.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKSVAIIGAGITGLSSAYFLKQQDPNIDVTIFEASNRPGGKIQSYRKDGYMIELGPESYLGRKTIMTELAKDIGLEQDIVTNTTGQSYIFAKNKLYPIPGGSIMGIPTDIKPFVTTKLISPLGKLRAGFDLLKKPTQMQDGDISVGAFFRARLGNEVLENLIEPLMGGIYGTDIDKLSLMSTFPNFKEKEEAFGSLIKGMKDEKNKRLKQRQLYPGAPKGQFKQFKHGLSSFIEALEQDVKNKGVTIRYNTSVDDIITSQKQYKIVYNDQLEEVYDGVLVTTPHQVFLNWFGQDPAFDYFKTMDSTTVATVVLAFDEKDIENTHDGTGFVIARTSDTDITACTWTSKKWPFTTPEGKVLIRAYVGKPGDTVVDDHTDNELVSIVRRDLSQMMTFKGDPEFTIVNRLPKSMPQYHVGHIQQIRQIQAHIKQTYPRLRVTGASFEAVGLPDCITQGKVAAEEVIAEL
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Sequence:
MSVITAAPLLALLREDDHTVKSYALHSINEVVDQLWSEVSNDITDIEALYEDSKFEDRKLAALVVSKIYYNLGEYESAVRYALAAEEYFDINEKSRYVETIVSQSIEMYIKLATENYGKEKSEIDLQLVSIFERMLNKCITAGEYKLALGIALESYRLDVVTNILTQQTSEPNMLKLITYVLIAATTTVSNTHFKINILYALFDILIRLKAPDYFAVSKIIVNLNDSKLAARLFDKLVSEKNTEIAYQIAFDLVTSASQGLLNELVATLSTGEGNDRLVEILSGLPTCDFYNTFLHANKRIDRSLLNKSKSSMDGKFSLFHTAVSVSNAFMHAGTTDDTFVRANLQWLGKAQNWAKFTATASLGIIHQGNLTGGKKIMEPYLPGSRASSRYIKGGSLYGLGLIYAGYGKEIIGYLKDQIVENSSNATDDDVDVLLHGASLGIGLAGMSSNSTEIFEALKEVLYADSANSGAAAALGIGLTMLGSGDETVAENLYTYAQETSHGEITKGLAIALALLNYGREELADETIKKMLEHENDSMRYGAVYTIALAYAGTSSNEAVKKLLHVAVSDSNDDVRRASVTALGFVLIRDYTTVPRIVELLSESHNPHVRCGTAFALGVACAGRGLQAAIDVLEPLTNDPVDFVRQAAMIALSMILIQQTEKTNVKVRDVNEQLRNVIANKHQEGLAKFGACVAQGIINAGGRNVTIQLENSEMGTLNTKSVIGLAMFTQFWYWFPLAHFLSLSFTPTTTIGVRSHDLKIPKFSFHCHTKEGIFDYPPMFEEDIDKSIEKVATAVLSTTAKAKARAKKSKKDKAVEPDKSKEEIKVENEQRDKKEHDADVPEEEFKIKYTSTYYKVENMTRVVPQQLKYIAFPKDERFTPVRKFKGSNGVIVLSDKTPDEPVEVIKTVRQEKETDAPLPAPFKVQDDLEF
The following text describes a protein:
Function:
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MNPAYRKAMLESEIQKLLMEALQQLRDPRLKKDFVTFSRVELSKDKRYADVYVSFLGTPEERKETVEILNRAKGFFRTFIAKNLRLYVAPEIRFYEDKGIEASVKVHQLLVQLGYDPLKDKEKKEEDKEEE
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification, facilitation of DNA opening and initiation of transcription (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEAVIANILQQLGFDSMTKAAEASFVEAVDKYLRNSFRELALHTQLSKHTIPTTKDVALWLNLLNIPMSSLQTELEKYLKPLPPAINDELDRLANESQDIPSKFKSSLDSKMVSQLLGSLAVSQNRPAYVVNHLPPFPASHTYMATPVYPVRPTSPKQIRELATQESRLAEHALRKILNVNQPRSADSPRHASFEKACSELNLDVSSFHLVNWESQKWSSQR
The following text describes a protein:
Function:
Ubiquitin ligase protein that mediates monoubiquitination of Fancd2. Ubiquitination of Fancd2 is stimulated by ionising radiation. Together with Fancd2, and probably FANCI, involved in DNA repair of damage caused by agents that induce interstrand cross-links but not agents that cause double strand breaks.
Subcellular Localization:
Nucleus.
Domain:
Contains three UBC-type E2-like WD40 repeat-containing folds. The 2nd and 3rd of these form the UBC-RWD (also known as the double-RWD or DRWD) region. The UBC-RWD region may be involved in binding Fancd2 and FANCI.
Sequence:
MESNEDVERLLCQKYPGLAAELQPSGACIIRGVLGSEDTWRRLKLYLPHHPALHGFQLYVQESLEYKLYTSANLKLQDDWLLEDFLDHLPKILPAQKAPTVPKELCREGNIYYDILALYKSNEYCLQVDEACSMIRFSEFTDFEQHYLELKIPSLLLLDHSLPDCVSLGEMLTKSAGNLEEALNLFRKLLEDLRPFYDNFMDIDELCHVLQPSPISSKHKTRLFPLKDRVYLKLTIADPFACIASMSLKIIGPTEEVARLRHVLSDGLSNWDSEMNIHKNLLRMFDLCYFPMPDWSDGPKLDEEDNEELRCNICFAYRLDGGEVPLVSCDNAKCVLKCHAVCLEEWFKTLMDGKTFLEVSFGQCPFCKAKLSTSFAALLND
The following text describes a protein:
Function:
Involved in pollen mitosis II (PMII) regulation during male gametogenesis.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MGSIRGDLQPLFVMPPPPLDEDCDDIFNSDESSWGLLSLSCFGIIMGLWFFASVCLIFGVYGSETVWLGPNSSILVKPSSIFVKSIKVKELDFSKPGLQLYGFNGQSTPSGYFVNWTESRVLSVSQNSYKGWPYYLNRGTHMNISYNILPKGSAVRLVITEGSQVIGMPFFYRSSLKDIAFRDTAWSWNLIQGSGMIQLDISKSKGYYLTVANLKRKDIEVELDIDVKAVLYDTKQTSYNCSFSNGECSFKMNERYPVENYAVVTSPALGQGVSIDDEWYIELSYQPRLIAYGSFTGVLLSFMLVAIHFCNKLKCCGGEGFLSGDDSVRTCLLADKGDNDCCNDVEASNKSLCAICFDAPRDCCFLPCGHCVSCYQCGTKIKRTKGRCPICRKKMIHVKRIYTA
The following text describes a protein:
Function:
Transcription factor which binds to 5'-GGAA/T-3' DNA consensus sequences. Both positively and negatively regulates the expression of target genes. Plays a role in the regulation of adult lifespan, which may in part be through modulation of daf-16 activity. Regulates the expression of genes such as svh-2 in response to axon injury and in addition, may function downstream of the cAMP signaling pathway to promote axon regeneration. Regulates the expression of lipid metabolism genes and may also control the expression of the RNA-binding protein rege-1 which too has been implicated in the control of fat accumulation.
Subcellular Localization:
Nucleus.
Domain:
The N-terminal part (1-345) is responsible for activating transcription, but this action may be modulated by the PNT domain which acts to repress transcription.
Sequence:
MNGTGSVGHRWNSLSPEPHSGTESTASTPFVKSEFPFDDDLFGIDQVNNVKPHPMDMPCNLPIQPIEYNRRFSKDADHSTFVKNEIEENILNFNVNPEIAQDNGLDTQQIDIYRDLILRHLIQDISTTCAKLGLPNDFYLWSSEHGARWINEMCMQFNLQPPRNCSITGIDLLGMSQKDFEMILPAGGDTLHAQLQVWKTGTSDYVKAFENYHPPVTVQSSGMTAAENNMQSKTNWLASTNNQTNNMAAAENPNHPFFNGNGGYPNMSMSSFFQQGTVLPSPSNSDTSSNGSSQDMNDDDIDLHMNNSNCGFSNFFHNQGYMNSPIDAMCNGSEGDDDERAYTRHQGTVHLWQFIRELLDQPKQYSACVRWVDRDEGTFKIESSLLLARYWGQRKNRSQMNYDKLSRSLRQYYKKGIIQKPEKKQRLVYKFLPPYNL
The following text describes a protein:
Function:
Seed storage protein.
Sequence:
MEKNKRAIGFLLLVVLINGVMMTRSNGYEGEEEWGGAGGGEWGGAEGGGAWGGGGGGGGAWGGEGEGGGEWGGGGEGGGGGRRGWFMMRESRQVIKSEGGEMRVVLSPRGRIIEKPMHIGFLTMEPKTLFVPQYLDSSLLIFIRQGEATLGVICKDEFGERKLKAGDIYWIPAGSVFYLHNTGLGQRLHVICSIDPTQSLGFETFQPFYIGGGPSSVLAGFDPHTLTSAFNVSLPELQQMMMSQFRGPIVYVTEGPQPQPQSTVWTQFLGLRGEEKHKQLKKLLETKQGSPQDQQYSSGWSWRNIVRSILDLTEEKNKGSGSSECEDSYNIYDKKDKPSFDNKYGWSIALDYDDYKPLKHSGIGVYLVNLTAGAMMAPHMNPTATEYGIVLAGSGEIQVVFPNGTSAMNTRVSVGDVFWIPRYFAFCQIASRTGPFEFVGFTTSAHKNRPQFLVGSNSLLRTLNLTSLSIAFGVDEETMRRFIEAQREAVILPTPAAAPPHVGEMVSDRFV
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MSTAAANPTLPLSIFVTPANDSLTREEISHLQQLVRDLVQGDTNLPGGVDSADGFDQIPYIIKQIFQTGREDAFGEQLNYYCSRKEAEIERMCNLHYQEFVQSVDQLLKVRAGTATMRDKIKIMNEDMQTAGSKIVEKRSELIENRRTILNIEMALETMQSCLFVLDIANRVSVQVGNRKYYSALRMLDELKTTHLALVNQYSFAAQMNDWVPYMQNSIREAVISELNQWTVTVKEMTDTVGRLAMELTAMRQDRASEILASSKYISKSGRNLNIGTSMELAINEEYDMDALDNEDVHLDFTALFQCIHIHDVLGKRAQFKAEYEENRRLQSEIIIGTVFSLKDGDISGFEKYIQQISGFFVIEATVISATADFRSRAGVEALWEMAVSKMNAHIGECLRDCTIPELFLDIKMCVVAFIQTMEVYGFSVTSVTDLMVSLVDRFAEVKKLQCCEKLLKVIEEEDDYMPVVVNNSDDLDQVNKAFQLPSDYFKNPTKLTGGAETILFPKILPFSKGFYKCCQYVKDFIYDYYRFADGFSQQSYEMDDLLKKSLENLLVQNLNGALMKKIGSTSLSLVIQIMINCQWFEKACGQFEEMLQEQRSVYKEVRVVLQVAQIFDETRAIAEKRVFEIVNTKIDGFLEVADYDWDAAQAANAPSAYLTDLVDYLTTVVSSTLSLLPSATKAYVYFEAFDHLTASLKSMLLDPQLKRVTIAVLHTLDIDIGYLETFIKQLNDTNAGDAFTELRQLINYGKSESYEDILVPAIRNKKYSRVDMNDAVTILEKLKNFDTSYFSKASSAEKQLKKDIENAIRLIKK
The following text describes a protein:
Function:
This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity); The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
Sequence:
MSQFNAYHKNARISAQKVRLVADLVRGMFADEALDTLKYQPQRGARMLEKVIKSAVGNAQDPDQNSGRSHRIEELVITDVRVDGGPMFKRIQPRARGMAFMIKKRSSHIRVGLTHIENV
The following text describes a protein:
Function:
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
Sequence:
MWASGSVKIPTHIAVIPDGNRRYAKKTGIDFYHAYKKGVEKVRNFLTWALEFRDIKNVTFFALSTENLQRSKIELEILFRIFEDELRRTLEDPLIHDNKVRVRFIGDRSLLPGKVVKYIDELESVTKNYSNYHLTIALGYGGRAEIVRCIKRVLSGEVRLETFSEEELFQCLDTRGIPNPEPDVVVRTGGEKRLSNFLLYQTAYSELIFLEKLWPEVEREDLVYIIEEYSRRQRRFGR
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.
Sequence:
MSSTPEVADALFHVRKTGFVDETMTQVLEQLFDCPQHGRVLETYMRGRHEDICMVLIKTLATTHNKSTLGVLLRLFADLARSSTVMGKTLGLCSSVLVDQEDPVQMFLYLATTHSRDRMISDPALYLAATTLRYADPKLNEESLERFFAIVNESLSVNPLQVEAVSFTVHNCAIMAHAKALRHYFFDNKLVQYFPRLLTDTIGDDAASLVQLTYEVLVVTWLLSYEVDGVVSLQEHKMLPHIHRVIQRMQKEKCIRVALMVLWNFVQAERQYMDAVTNPSDATWVSDEIFKLARVNGGKGPSFIAEMVGVGMLKTLTQLARRKFGDEDISELIQDLLNVLENSMETLTSFSEYRGEVLSGSLEWTPVHTCAKFWQSNIMQFEKNGYEVLEALGNIIMNSTNSLTLAVACHDIGEIVRHHPTGRALLQLPQLEGVMARVMELMSHETPEVAKNALLSVQKIMVQRWECI
The following text describes a protein:
Function:
Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF).
Subcellular Localization:
Cell membrane. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus. Membrane, clathrin-coated pit. Nucleus.
Sequence:
GGTRTQGKGKGKDNKMSGQSITDRIAAAQHSMTGSAISKAVCKSTTHEVIGPKKKHLDYLIHCTNEMNVSIPQLADTLFERTANSSWVVVFKALITTHHLMMYGNERFIQYLASRNTLFNLNNFLDKGALQGYDMSTFIRRYSRYLNEKALSYRLVAVDFTKMKRGIDGVMRTMNTEKLIKTLPIIQNQLDALLDFEANPNELTNGVINAAFMLLFKDSIRLFAAYNEGVINLLEKYFDMKKNQCKEALDIYKKFLYRMTKLSEFLKVAEQVGIDQGDIPDLTQAPSSLLEALEQHLASLEGKKTKEFSAASRANTLSNAVSSLSSTGMSFSRMDEKEKQQALEEEQARLQSLKDQRLKEIGMQTPTVSPSTQSGGSTNNATSTSVDLFSTPATAPSTNSMPNLNSDLFDLQPAFVPTVQSTPAISTSVNSAWGASWSSLYQAAVKGVLSVLAFCCKCSSDDHVLSAVEAPKIVPALFSGLDAHPIQQSVPMPTMSVDFDAVFGNKVANNDVKPASGDLLKPTGTATQSQPPPVLGGKLLANDLDSSLANLVGNLQFGGTPAKKPDMHWTQPGEKKLTGGTNWQSKTMSTTTAWSPAPLAPAPMPVPQMAPAPLAFPMTTPQVPMYGMVPPQMGGVPMMASQPMMFNQPVLRPTNPFTPIPGAQVTVL
The following text describes a protein:
Function:
Component of the central CCA1/LHY-TOC1 feedback loop in the circadian clock that promotes clock accuracy and is required for sustained rhythms in the absence of daily light/dark cycles.
Subcellular Localization:
Nucleus.
Sequence:
MEGDVLSGFGDRHNMDGKLLQSFQKSFVDVQDILDQNRLLINEINQNHESKQPDNLGRNVGLIKELNNNIRRVASLYGDLSHSFARSVDASSEGESSGTLKSDGKANQKRFRSG
The following text describes a protein:
Function:
Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.
Subcellular Localization:
Cytoplasm.
Sequence:
MAIVVVGAGTAGVNAAFWLRQYGYKGEIRIFSRESVAPYQRPPLSKAFLTSEIAESAVPLKPEGFYTNNNITISLNTPIVSIDVGRKIVSSKDGKEYAYEKLILATPASARRLTCEGSELSGVCYLRSMEDAKNLRRKLVESASVVVLGGGVIGLEVASAAVGLGKRVTVIEATPRVMARVVTPAAANLVRARLEAEGIEFKLNAKLTSIKGRNGHVEQCVLESGEEIQADLIVVGIGAIPELELATEAALEVSNGVVVDDQMCTSDTSIYAIGDCAMARNPFWGTMVRLETIHNAVTHAQIVASSICGTSTPAPTPPRFWSDLKGMALQGLGALKDYDKLVVAINNETLELEVLAYKQERLIATETINLPKRQGALAGSIKLPD
The following text describes a protein:
Function:
Molecular adapter required to prevent protein hyperglycosylation of HSP90B1: during translation, associates with nascent HSP90B1 and the STT3A catalytic component of the OST-A complex and tethers them to a specialized translocon that forms a microenvironment for HSP90B1 folding. In the CCDC134-containing translocon, STT3A associates with the SRT pseudosubstrate motif of HSP90B1, preventing access to facultative glycosylation sites until folding is completed, preventing hyperglycosylation and subsequent degradation of HSP90B1. In extracellular secreted form, promotes proliferation and activation of CD8(+) T-cells, suggesting a cytokine-like function. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling. May also localize in the nucleus: enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated histone acetyltransferase activity. Has a critical role in the regulation of osteogenesis and bone development.
Subcellular Localization:
Endoplasmic reticulum lumen. Secreted. Cytoplasm. Nucleus. Note=Mainly localizes to the endoplasmic reticulum. Accumulates in the nucleus in response to UV irradiation.
Sequence:
MDLLQFLAAFSVLLWPGTEVTGALKSTLDPSLKIYKKMFEVKRREQLLALKNLAQLNDIHQQYKILDVMLKGLFKVLEDSRTVLIAADVLPDGPVPQDEKLKDAFSHVVENTAFFGDVVLRFPKIVHHYFDHNSNWNLLIRWGISFCNQTGVFDQGPHSPILSLMAQELGITEKDSDFRNPFKTDQTEFIPSTDPFQKALREEEKRRKKEERRKEIRKGPRISRSQSEL
The following text describes a protein:
Function:
May act in meiotic drive.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to the endoplasmic reticulum in both vegetative cells and in spores.
Sequence:
MENNHHLAKDSLDELNPKRGKGEHETQVSQYTVVEEATIPQSLVKTSRSADHKVMEASKVADTRTAWSTKIPAVLLPVFVINIALFKYLVFANFSTKDRVLFGLGNGGINIFSMWLLLATYETWFRSIKEVIVACGAGIRSFPQKRGVNMLYAILKLTFVNAFAIPLLMFFRSHFEQWRLGCPLVERVIGVMLNVAYFIIEIENPGLFTRVFNKYCDCLFAIRDILNRN
The following text describes a protein:
Function:
Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP (By similarity). Necessary for the formation of a functional phosphodiesterase holoenzyme. Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock. May participate in processes of transmission and amplification of the visual signal (By similarity).
Subcellular Localization:
Membrane; Lipid-anchor. Cell projection, cilium, photoreceptor outer segment.
Sequence:
MSLSEEQVRSFLDGNPTFAHQYFGKKLSPENVAGACEDGWLADCGSLRELCQVEESAALFELVQDMQESVNMERVVFKILRRLCTILHADRCSLFMYRQRNGIAELATRLFSVQPDSLLEDCLVPPDSEIVFPLDIGIVGHVAQTKKMINVQDVAECPHFSSFADELTDYVTKNILSTPIMNGKDVVAVIMAVNKLDGPCFTSEDEDVFTKYLNFATLNLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWPVLMGEAQPYSGPRTPDGREIVFYKVIDYILHGKEDIKVIPTPPADHWALASGLPTYVAESGFICNIMNASADEMFNFQEGPLDDSGWVIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDDQDEVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQDMVLYHVRCDKDEIQEILPTRDRLGKEPADCEEDELGKILKEELPGPTKFDIYEFHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVLVRFLFSVSKAYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLAEESLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDESKNYEDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEEKKKEEDRVAAKKVGTEVCNGGPAPKSSTCCIL
The following text describes a protein:
Function:
Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity).
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MATNNNNNNGNPILRSLETSCCFLATLFPKVFCTLVLTWSLYVLLFIIPNYIKSSLNSTILNIIGITLYVLCIISYYKIILIGPGSPLDYPELRINDLNRMINENPYNNNNNDEEPGDLPPESMIIHTMKVNGNQGYRYCTKCSVWKPDRSHHCSSSGKCILKMDHYCPWFSTCIGFHNYKFFIQFLSYVAIYCWFLFIISGKILYNFITEGLFEDEILSLNLVAVLILSFAFAIAVSVFAMFSIYLCCKNLTTIEFQEKRWNYRGQANDERFNYEFDNNGKRKKINTNIFDLGIMENWKSVMGPNWITWILPITVTVTANTKSMISQDEFNNGVNFKVNEEIYAKYLHNAELQQQLNQQLSSYKDRLRRERQANIV
The following text describes a protein:
Function:
3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFAPLGLFRDIPCPQREECSLIACLFSHRDLNSAPAAQDQVLEQKEPAKLPPKRLKLEPRPEAKETPKDDLRHVSDSGRSTPVKKTTAPATNAENISPVSRQPNIPKNTATAPIKRELNANTGSSIPPRRAPKEALNPRMIQKSPATYNVRMAILKKLHGTLCSLNDQLAKDKALEDKCLILTPDELITMALDEEEKVAKESPTVYSNVVKLRIVKLSRMSKEDWAKELKDYLNKKYYKIKAEPVQKEPKPFKTDLSVEEEIAVASQLITPLQGLEDFGYVTRVPTAEEIEIAKRGVAEAKGWEKCERCNARFQVFPGRREDGTLTSGGTCTYHPGKSFYPPRKKTDHITGTMREGYFTCCNQKLGESSGCTTGATHVYKVSETKRLASILQFEKTPENPDLHNPTPICFDCEMGYTTLGMELIRLTAVSWPEGKKVLDVLVRPLGEVLDLNSRFSGVFPEHYTNALPYSTAPTKSSAPSSSSPSQLQLVSSPAAARTLLFNLLTPSTPLIGHAIDNDLNACRIIHPTVIDTAILYPHPGGGLPYRMSLRTLAKKHLDREIQTGGASGKQGHDSVEDALATGDLVRVKAGLVWGRLKEKGWIVEEGRLVAPDSSSNTVSMQTKLGEGAGAKRAREGTS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MATESKKATAQNLQEDEGLLIVKMEEEDFVWRQGACLQRNDPLRQELCRRLFRQFCYQDSPGPRDALSQLRQLCCQWLKPETQTKEQILELLILEQFLAILPGDLQAWVRERYPESGEEAVTLLEDLERGTDEAVLQIPVCGHGQEPFRRKVASPGPALSVPFQPVDTTALHGSSEPQLLLDCDNKSENSESMPKLDIYEKMESQKIVSGRISEFVSEGSAEPQDICKSAGKIKRQQEKDSGESQKSSSAQDAAFSKILTHKNTLRGEIISHDGCERNLNLNSNEFTHQKSCKHSTCDQSFKWNSDFIKHQRIYAGEKIHPYGKSLKNPNLIKHAAVFTGEKTHQCNECGKAFRHSSKLIRHQRIHTGERPYECNECGKGFGGSSDLIRHQRIHTGERPFECKECGRAFSLNSHLILHQRIHTREKPYECSECGKTFRVSSHLIRHLRTHTGEKPYECSECGRAFSQSSHLSQHQRIHKRENLFM
The following text describes a protein:
Function:
Induces mitochondrial fragmentation, possibly by promoting DNM1L-dependent fission and may play a role in mitochondrial morphogenesis during spermatogenesis.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatus. Mitochondrion intermembrane space.
Domain:
The N-terminal domain is required for targeting to the mitochondrion.
Sequence:
MAAQARTPRSRILGCSSMLRFLRSLVGSKGSSKSSNRPLNRSQPSSSPEQDVVSPTMGHQGGCGRKETRPRVLSATSSNGKREPRPRVLSAAPSNQRLRDASGLGTGDTGSQTLTSKDVLKLRAQGVEVTSVPTRGTWEVLEHLPEKKGEEGEPAGEVSGASDRAHFGQALEAEQGCLQWVSGPMVLPPEAFIKEEEDEHCLIDFGDLRLSSCKVGSTPWNYLLGLYKQLQKSAMTKAQRPDADAPQFALKDSSPTEERGEREEAVDESSLKWCAPRASSDDSNLKWCAPRNSTYQSPLQKTFRSTDTVGFVESELKKILAVQREARLWKVGNPEGRELLTQPDITLEEAGMVDGQHLLLEEMDEMGNWPPPE