lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity); [Isoform 2]: Essential for the survival of colon cancer cells to bile acid-induced apoptosis.
Subcellular Localization:
[Isoform 1]: Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side; [Isoform 2]: Cytoplasm. Note=Localized close to nucleus on the apical side of both normal and neoplastic cells.
Domain:
Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. Can bind at least two ligands per molecule, however, the stoichiometry is debated.
Sequence:
MAFTGKFEMESEKNYDEFMKLLGISSDVIEKARNFKIVTEVQQDGQDFTWSQHYSGGHTMTNKFTVGKESNIQTMGGKTFKATVQMEGGKLVVNFPNYHQTSEIVGDKLVEVSTIGGVTYERVSKRLA
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MIRSTFKLCFLFIFLSSISLVKAEGEDLDVEFDYDPESNHGPDHWADLKPSWSTCRDGQLQSPIAINVTEDSVDLTLSKLNVMYLPSEAVLRNNGHGIELNFLNFAGRLMLNGDAYFLQQLHFHSPSEHIIQRVRFPLEMHLVHRSESGEEAVISVPFLKSYHSDFLDQFWDLLPQVSDKYAEVKVETVSVNLPVGPFYARYNGSMTTPPCTENVSWTVCLWKWNTVSEDQLKALKALDLGPNSRPLVDDNGRDVSLFLSRS
The following text describes a protein:
Function:
Probable serine lipid hydrolase associated with lipid droplets (By similarity). Appears to lack or have very low cholesterol esterase activity (By similarity). Appears to lack triglyceride lipase activity. Involved in cholesterol and triglyceride homeostasis; stimulates cellular triglyceride accumulation and cellular cholesterol release (By similarity). Involved in negatively regulating juvenile hormone (JH) and possibly, insulin signaling activities such as triacylglycerols (TAG) storage, and thereby plays a role in the endocrine regulation of organismal growth and survival. Likely functions by enhancing the activity of the JH hydrolase enzymes Jheh1 and Jheh2. Required for lipid droplet positioning and fat storage.
Miscellaneous:
MISCELLANEOUS: 'Sturkopf' means 'stubborn person' in German. The name originates from mutant larvae which do not adjust their developmental timing to their nutritional conditions.
Subcellular Localization:
Lipid droplet. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to the endoplasmic reticulum in absence of lipid droplets and translocates to lipid droplets upon lipid storage induction.
Sequence:
MQEAYVNINSIPTHIFTWGRWIEETITEKEIVICITGNPGLPGFYTEFAGTLQKELGDLPVWVIGHAGHDDPPEASIREVPQLSGNEELFNLDGQIRHKIAFIEKYVPSDVKIHLIGHSIGAWMILQLLENERIRSRIQKCYMLFPTVERMMESPNGWVFTKVAMPLYSVFGYIFFSFFNFLPVWLRLMLIQIYFLIFSIPRQFLGTALKYSKPSVAEKVVFLADDEMARVRGIQREIVEQNLDLLKFYYGTTDGWVPISYYDQLKKDYPKVDAQLDTKKIDHAFVLRHSQPMAVIVRDMIQQHRRV
The following text describes a protein:
Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVRLKNRYVLGELILDDGRTATEAKLNTRVTQQAIHTVIKQLHGDFGIGAVTAGFVVKYVGLQTNTVLIKVRHRAIRYLTSSLPFVMSISKVPCCFLTLHVAGTMRACQKFLVKHDRRQLTILFKNSKTQTERNTVLDALKRCQAKETLWVEPKDDSFTDDDDSDEGR
The following text describes a protein:
Function:
Catalyzes the acetyl-CoA-dependent acetylation of lysine residues of a large number of target proteins. Acetylates RNase R in exponential phase cells and RNase II. Required for the glucose-dependent acetylation on multiple lysines of alpha, beta and beta' RNAP subunits. Also acetylates acetyl-coenzyme A synthetase (Acs) and the chromosomal replication initiator protein DnaA, and inhibits their activity. Overexpression leads to the acetylation of a large number of additional proteins and inhibits motility.
Sequence:
MSQRGLEALLRPKSIAVIGASMKPNRAGYLMMRNLLAGGFNGPVLPVTPAWKAVLGVLAWPDIASLPFTPDLAVLCTNASRNLALLEELGEKGCKTCIILSAPASQHEDLRACALRHNMRLLGPNSLGLLAPWQGLNASFSPVPIKRGKLAFISQSAAVSNTILDWAQQRKMGFSYFIALGDSLDIDVDELLDYLARDSKTSAILLYLEQLSDARRFVSAARSASRNKPILVIKSGRSPAAQRLLNTTAGMDPAWDAAIQRAGLLRVQDTHELFSAVETLSHMRPLRGDRLMIISNGAAPAALALDALWSRNGKLATLSEETCQKLRDALPEHVAISNPLDLRDDASSEHYIKTLDILLHSQDFDALMVIHSPSAAAPATESAQVLIEAVKHHPRSKYVSLLTNWCGEHSSQEARRLFSEAGLPTYRTPEGTITAFMHMVEYRRNQKQLRETPALPSNLTSNTAEAHLLLQQAIAEGATSLDTHEVQPILQAYGMNTLPTWIASDSTEAVHIAEQIGYPVALKLRSPDIPHKSEVQGVMLYLRTANEVQQAANAIFDRVKMAWPQARVHGLLVQSMANRAGAQELRVVVEHDPVFGPLIMLGEGGVEWRPEDQAVVALPPLNMNLARYLVIQGIKSKKIRARSALRPLDVAGLSQLLVQVSNLIVDCPEIQRLDIHPLLASGSEFTALDVTLDISPFEGDNESRLAVRPYPHQLEEWVELKNGERCLFRPILPEDEPQLQQFISRVTKEDLYYRYFSEINEFTHEDLANMTQIDYDREMAFVAVRRIDQTEEILGVTRAISDPDNIDAEFAVLVRSDLKGLGLGRRLMEKLITYTRDHGLQRLNGITMPNNRGMVALARKLGFNVDIQLEEGIVGLTLNLAQREES
The following text describes a protein:
Function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Sequence:
MSFNESASIPTGLTYDDVLIIPQHSRVTSRKEVNTTTRLSRNVKLSIPIVASNMDTVCEQRMAVAMAREGGIGILHRFCSIEEQCAMLREVKRAQSFLIESPRIILPHETAREAWEGLNWKGRVGGVGCLLVVNCKNERKLLGIITRHDLKLADESTTVESLMTPVDKMVVSTNTSISLEEVTHLMRKGRTANVPIVGQNGQLLYLVTLSDVVKLRKNKQASLDSRGRLLVGAAVGVKKDDMNRAIRLVEAGADVLVVDIAHGHSDLCINMVKRLKGDPRTASVDIIAGNIASAEAAEALIDAGADGLKIGVGPGSICITRLVAGAGVPQLSAVLACTRVARRRGVPCIADGGLRTSGDISKAIGAGADTVMLGNMLAGTDEAPGRVLVKDGQKVKIIRGMAGFGANLSKAERERTQDEDVFSSLVPEGVEGSVACKGPVGPIVRQLVGGLRSGMSYSGAKSIEEMQRRTRFVRMTGAGLRESGSHGVAKL
The following text describes a protein:
Function:
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections. The first step of the pathway is the formation of the heptaketide backbone by gsfA which is initiated by priming with acetyl-CoA, followed by sequential condensations of 6 malonyl-CoA units. The resulting benzophenone can undergo a spontaneous dehydration to form norlichexanthone. However, the true precursor for the griseofulvin biosynthesis is not norlichexanthone, but the heptaketide benzophenone that is O-methylated at 3-OH by gsfB to produce griseophenone D which is further methylated at 9-OH by gsfC to yield griseophenone C. Griseophenone C is then substrate of halogenase gsfI which is responsible for the regio-specific chlorination at the C13 position to form griseophenone B. The cytochrome P450 gsfF catalyzes the coupling of orcinol and phloroglucinol rings in griseophenone B to form desmethyl-dehydrogriseofulvin A which is further methylated at 5-OH by gsfD to yield dehydrogriseofulvin. Finally, gsfE performs stereospecific reduction of enone 18 of dehydrogriseofulvin to afford the final product griseofulvin.
Sequence:
MTLDQISRIQALVAEIADLSQTFEGPSERFMVDGLPFLRKSEELVTLVQSPAEHATSLIIKTMETAVIRTLLSLNVLQTIPTTGSITLQSLAVATETQESLLERLLRVVTKTGFIIRENGGYSHSHTSLAYAGPLGALFAPCYDEGIRALVRLPEYLSVKDKEEAKNARYSLFTWNEGQEGKATFEILSTMPARTEGIHTLAMNVQHLRPYTGFFDYSKLVSEDRERPVFVDVGGGNGHVIKEILQAFPQIRPEQCVLEDRAETLELARTTGLLPAGVQLLEHDYLTRQPVSNAKAYHLRAVAYNLGDAELVQLLKQIVPVMGADSKVLIAENILFDDNSTVFSTVSDMIMLGIGGKERTEQNFREVLYEAGLTIEGIHRAPGLEYGIMEASLATS
The following text describes a protein:
Function:
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.
Sequence:
MTNNAAAPLYSLRGLPLIGWRDMSHALNYLFADGQLKQGTLVAINAEKLLTAEDNPEVRALIAAAEFKYADGISVVRSIRKKFPQAQVSRVAGADLWEALMARAGKEGTPVFLVGGKPEVLAQTEAKLRTQWNVNIVGSQDGYFTPEQRQALFARIHASGAKIVTVAMGSPKQELLMRDCREVHPHALYMGVGGTYDVFTGHVKRAPKIWQNLGLEWLYRLLSQPRRITRQMRLLRYLRWHYTGDL
The following text describes a protein:
Function:
Substrate adapter of E3 ligase complexes mediating ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, and which is involved in various processes, such as ribosome recycling and reticulophagy (also called ER-phagy) (By similarity). As part of the UREL complex, plays a key role in ribosome recycling by promoting mono-ufmylation of RPL26/uL24 subunit of the 60S ribosome (By similarity). Ufmylation of RPL26/uL24 occurs on free 60S ribosomes following ribosome dissociation: it weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane (By similarity). Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum (By similarity). Within the UREL complex, CDK5RAP3 acts as a substrate adapter that constrains UFL1 ligase activity to mono-ufmylate RPL26/uL24 at 'Lys-134' (By similarity). The UREL complex is also involved in reticulophagy in response to endoplasmic reticulum stress by promoting ufmylation of proteins such as CYB5R3, thereby promoting lysosomal degradation of ufmylated proteins (By similarity). Also acts as a regulator of transcription: negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (By similarity). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (By similarity). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (By similarity). May also play a role in the rupture of the nuclear envelope during apoptosis (By similarity). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (By similarity). Required for liver development (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Note=Tethered to the endoplasmic reticulum membrane as part of the UFM1 ribosome E3 ligase (UREL) complex. Colocalizes and associates with microtubules.
Domain:
The shuffled ATG8-binding motifs mediate interaction with both ATG8 family protein and UFM1; The RPL10a-binding domain (RBD) anchors the UREL complex onto the ribosome via association with RPL10a/ul1.
Sequence:
MQDHQHVPIDIQTSKLLDWLVDRRHCNLKWQSLVLTIREKINTAIQDMPESQEIAQLLSGSYIHYFHCLRIVDLLKGTEASTKNIFGRYSSQRMKDWQEIISLYEKDNTYLVELSSLLVRNVNYEIPSLKKQIAKCQQLQQDYSRKEEEGQAGAAEMREQFYHSCKQYGITGDNVRRELLALVKDLPSQLAEIGAGAQSLGEAIDLYQACVEFVCDSPTEQVLPMLRYVQPKGNSTVYEWRTGTEPSVVERPQLEDPPEQVQEDEIDWGDFGLEAVSDSGNIISAETPGIDWGISLESESKDAGADKIDWGDNAVASEITVLETGTEAPEGVARGSDALTLLEYPETRNQFIDELMELEIFLSQRAVEMSEEADILSVSQFQLAPAILQGQTKEKMLSLVSTLQHLIGQLTSLDLQHLFMILASPRYVDRVTELLQQKLKQSQLLALKKDLMVEKQQEALQEQAALEPKLDLLLEKTRELQKLIEADISKRYNGRPVNLMGTSV
The following text describes a protein:
Function:
Catalyzes the efficient dehydration of both L-talarate (also called L-altrarate) and galactarate to 5-keto-4-deoxy-D-glucarate (5-KDG). Also catalyzes the epimerization of L-talarate to galactarate; epimerization occurs in competition with dehydration. Is required for the utilization of L-talarate as a carbon source. Also functions in galactarate utilization. Is not active on other acid sugars.
Miscellaneous:
MISCELLANEOUS: The enzyme product is the enantiomer of the product obtained in the galactarate dehydratase reaction catalyzed by OB2843; the enzymes thus differ in their regiochemistry of dehydration.
Sequence:
MALSANSDAVTYAKAANTRTAAETGDRIEWVKLSLAFLPLATPVSDAKVLTGRQKPLTEVAIIIAEIRSRDGFEGVGFSYSKRAGGQGIYAHAKEIADNLLGEDPNDIDKIYTKLLWAGASVGRSGMAVQAISPIDIALWDMKAKRAGLPLAKLLGAHRDSVQCYNTSGGFLHTPLDQVLKNVVISRENGIGGIKLKVGQPNCAEDIRRLTAVREALGDEFPLMVDANQQWDRETAIRMGRKMEQFNLIWIEEPLDAYDIEGHAQLAAALDTPIATGEMLTSFREHEQLILGNASDFVQPDAPRVGGISPFLKIMDLAAKHGRKLAPHFAMEVHLHLSAAYPLEPWLEHFEWLNPLFNEQLELRDGRMWISDRHGLGFTLSEQARRWTQLTCEFGKRP
The following text describes a protein:
Function:
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
Domain:
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence:
MQPFFLQGTVKPAVPFDKDADATALYEAMAGFGTDEDAINAILTKRSNNQRQEIKEAFKTKYTQDLVDSLKDELSGDYRKTVKALMDEPAVMIARCLNNLCQCGGDKMEIGLLEIIYPLSATDVLGIAAIYKETFSTVLHEDVSKSDTGPFKDVILNILVGERSSSIRVDTAAANDDADFFFKTKPEDWQLPNERVETLFGRASISQLRQTFTQADAANNLSLEKVMQDSKMDETQKAAFTVIFKSMCQPLGFYVDSLYWAMKGLGTDDDKLIRIVVGRSEIDLASIKKMFKEKYPTTTLAAMVEDDTSGDYKNVLIGIINADAAPTPAPTTT
The following text describes a protein:
Function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein; Extracellular side.
Sequence:
DRVPRPRSRGQQSPPRGASLPPSRAPHAGAALGWAFVAFVSAVGSIHCGPGAALLPRSPSPGKGLVRPGSGASTRAPRARGPCPGPRTGGESAGCRGPRYRRAPPRLALGALLRRRHLRRGLLSRGPARPGGCPSGAPAGPAGTARPRRPRGPAPPGTGRADTRGAPAAWAPAAPLPPRYLPRPGSRRPPPEAATGSARRARAAQPPSPPSPSRASGRPGLPSALPAPPPPPPAARDASRRGQILDAVVREQRPSVLLELGAYCGYSAVRMARLLEPGARLITIELNPDFAAITQQMLDFAGLQDRVTILTGASQDTIPELKKKHDVDTLDMVFLDHWKDRYLPDTLLLEECGLLQKGTVLLADNVICPGTPEFLAYVRGNNRFECTHFPSYLEYSKRVDGLEKVVYKGPGSPTQP
The following text describes a protein:
Function:
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MVGKSLIAGVVVLLVAAVSLFLGVFMAFGKKNTPPSSDHFYSKAAVAADAGKCSEVGRDILKKNGSAVDASIAALLCVGLLNAHSMGIGGGLFFVIYNASTGKVETIDARETAPMNATEDMFGNNTKLSRTGGLSIAIPGEIRGYEMAHKRHGRLPWKELFEPSIALARDGFPIGKALAHALFKSKDSIQRNANMCEVFCDSENNILKENDIIRFPKLADTYQRIAEEGPDVFYNGTMARSIVEDIQAEGGIITLDDLLEYQPVLNENPLKLNIGEYTIHIPDAPSSGPVLALILNIVDGYNFSDTSVSTAEKKTLTYHRIVEAFRFAYAKRSRLGDPRYLNITDLIQNMTSDYFADGIRNKITDDTTHPDTYYEPDYFVPENHGTAHLSVIAEDGSAVAATSTINLYFGSKVMSRSTGIIFNDEMDDFSSPYMTNGFGIPPSPNNFIQPGKRPLSSMCPTIIFDKENRVKMVVGASGGTKITTATALVCRTHSLTSLCSTFQHMRRLKLSSVFWNKKQVILNSLFFNYDLKKAVKEPRVHNQLNPNMTVVEQGFEKSVLDGLAQKNHVTQLLRTPDSVVQAVVRLGEHLCAESDPRKGGYPAGY
The following text describes a protein:
Function:
Probable oxidoreductase that may play a role as regulator of mitochondrial function.
Sequence:
MTGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGGMASTVELFDGYRFEIAGSVQFPTSSAVSSELGLDSLPTVDLEVMSVALRGVGDDPVVQFTDPTKMLTHLHRVHGADAVTGMAGLLAWSQAPTRALGRFEAGTLPKSFDEMYACATNEFERSAIDDMLFGSVTDVLDRHFPDREKHGALRGSMTVLAVNTLYRGPATPGSAAALAFGLGVPEGDFVRWKKLRGGIGALTTHLSQLLERTGGEVRLRSKVTEIVVDNSRSSARVRGVRTAAGDTLTSPIVVSAIAPDVTINELIDPAVLPSEIRDRYLRIDHRGSYLQMHFALAQPPAFAAPYQALNDPSMQASMGIFCTPEQVQQQWEDCRRGIVPADPTVVLQIPSLHDPSLAPAGKQAASAFAMWFPIEGGSKYGGYGRAKVEMGQNVIDKITRLAPNFKGSILRYTTFTPKHMGVMFGAPGGDYCHALLHSDQIGPNRPGPKGFIGQPIPIAGLYLGSAGCHGGPGITFIPGYNAARQALADRRAANCCVLSGR
The following text describes a protein:
Function:
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Subcellular Localization:
Secreted.
Sequence:
MKILVALAVIFLVSTQLLAEEIGANDDLNYWSDWSDSDQIKEELPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKRHKTDSFVGLMGKRALNSVAYERSAMQNYERRRK
The following text describes a protein:
Function:
Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
LTDSLKQNINKIECTPEMQTLIYDAVLNPNKLNEHAWVKLVESVTIKATQNLSHGRAAAKICNDIAQTEQRLAETTGKEKVFRKTLLNQLQSVYTRHKENQYRNVDTWVGFVNFLCSVFDVLQINNMPLMVLISPVYEVLNILTEERFIEKEIAIQCLVTQLQFIGEEIEKHNKAKMKDLVKQLNKMFLSDKTSQLSRLMLLEIIELQCGGWKLSRDAYAYYYEEVVK
The following text describes a protein:
Function:
Involved in multiple distinct defense responses. May function as a disease resistance (R) protein.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice site.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MSAYTSLNFLFLLTFFIGSLRVSAQLQDPTYVGHVCTNRISRNSIYFSNLQTLLTSLSSNNAYFSLGSHSLTKGQNSDMVFGLYLCKGDLSPESCRECVIFAAKDTRSRCPGGKEFLIQYDECMLGYSDRNIFMDTVTTTTIITWNTQKVTADQSDRFNDAVLSLMKKSAEEAANSTSKKFAVKKSDFSSSQSLYASVQCIPDLTSEDCVMCLQQSIKELYFNKVGGRFLVPSCNSRYEVYPFYKETIEGTVLPPPVSAPPLPLVSTPSFPPGKGKNSTVIIIAIVVPVAISVLICVAVFSFHASKRAKKTYDTPEEDDITTAGSLQFDFKVIEAATDKFSMCNKLGQGGFGQVYKGTLPNGVQVAVKRLSKTSGQGEKEFKNEVVVVAKLQHRNLVKLLGFCLEREEKILVYEFVSNKSLDYFLFDSRMQSQLDWTTRYKIIGGIARGILYLHQDSRLTIIHRDLKAGNILLDADMNPKVADFGMARIFEIDQTEAHTRRVVGTYGYMSPEYAMYGQFSMKSDVYSFGVLVLEIISGRKNSSLYQMDASFGNLVTYTWRLWSDGSPLDLVDSSFRDSYQRNEIIRCIHIALLCVQEDTENRPTMSAIVQMLTTSSIALAVPQPPGFFFRSNHEQAGPSMDKSSLCSIDAASITILAPR
The following text describes a protein:
Function:
The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face. SWD3/CPS30 establishes COMPASS trimethylation activity and may also serve as the anchor point to properly tether and space the other subunits.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MFQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLWRWV
The following text describes a protein:
Function:
Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.
Sequence:
MQVTVGDYCWLERKGFGFRQLLPEKWASAVLESRKEKVHWETCLGVNPQTKHACNPMEKVWMFHYDERHKMFVYVNSAFSPNPDELVIDLYNNFGFDGKLVVNYACSMAWG
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAWLSYGVEGTGDLNENSVENLQQKTLQDLLHGLSSWLVLEGMASTITGSQDCIVNHRGEVDGEPELDISPCQQWGEASSPISRNRDSVMTLQSDCFENIESETYLPLKVSSQIDTQDSSVKFCKNEPQDHQESRRLFVMEESTERKVIKGESCSENLQVKLVSDGQELALPLLNGEATCQNGQLKESLDPIDCNCKDIHGWKSQVVSCSQQRAHTEEKPCDHNNCGKILNTSPDGHPYEKIHTAEKQYECSQCGKNFSQSSELLLHQRDHTEEKPYKCEQCGKGFTRSSSLLIHQAVHTDEKPYKCDKCGKGFTRSSSLLIHHAVHTGEKPYKCDKCGKGFSQSSKLHIHQRVHTGEKPYECEECGMSFSQRSNLHIHQRVHTGERPYKCGECGKGFSQSSNLHIHRCIHTGEKPYQCYECGKGFSQSSDLRIHLRVHTGEKPYHCGKCGKGFSQSSKLLIHQRVHTGEKPYECSKCGKGFSQSSNLHIHQRVHKKDPR
The following text describes a protein:
Function:
Single-stranded DNA-dependent ATP-dependent helicase.
Subcellular Localization:
Nucleus.
Sequence:
MGSRSKDTTVILLDVSTSMHPHLQETIRCLQGYLQQKFLSASGQKDEVGLVLFGCDYTDNDLNEQMGGYEGVIVANPIQPVNLNFVKQLDTLPKGDGTADFLDAVVVGLGLLIERAGDKKLAGKKRLWLLTNLESPVKEPAEGTIEEQAATIAGTMVEKEIRLEVTRIHFKQEVQTSTSIQNEILLRRFVGETHGQIQTVSSALALSGTLATATPAKAPTTTYRGPLEVTPNLKINIWCYKKTVEAKLPSLKGYSDRAPASDPTAQHEMERITAYKSTADPDREVPPAEHTKAYRYGPQFIPVDQHVEEGLKFRADKGVKVIGFTHSKHVPRHLFMKDSNVFIAEPTNETAAVSFSALVRAMHQTHRVAILRCVYRANQGSVALSVGTPCPAEEDHLPDSLIVNQLPFAEDVREYPFLALADQPESKQPSLEQMDLAEQLVQKLDLAPAAGEELLAPEATPNPTLERFYNFLHKRAVEPEAALPPITPTARAVIEPPPRLLEAATPLIEDFQTKFSLTVAAIEDKPSKRFWRDRHAGQDEAPGQLDNGASTSGTAADPISLDDLAARKVDEVGTVNPVQDFNSMIARTDDPNLIPKAIKGMKDVIDNLVTQAYQGNTYDQALECLRALRRGCILQSEPLEFNSYLREIAARSKGKRQHDFWERLVKNQLTLINRDEEPDSDVLPEEAQKFLTEAEAKPPSAVEEPEKDEEVDEMAELLDMAE
The following text describes a protein:
Function:
Has a dual role as a segment polarity protein and as a modulator of the Abd-B protein. Required for Abd-B to activate the transcription of genes (including ems, cut and sal) that are involved in posterior spiracle morphogenesis. Also required for Abd-B to form an eighth abdominal denticle belt. Acts in a hierarchy downstream of drm and upstream of bowl during foregut and hindgut patterning and morphogenesis. Involved in cell rearrangement during elongation of the embryonic hindgut. Required to regulate expression of embryonic hindgut patterning genes in order to establish the large intestine and at least some rectum, and to repress small intestine fate. Required for late wingless (wg)-dependent cell fate specification in the dorsal embryonic epidermis. Acts in concert with wg to regulate expression of wg itself and also to regulate wg-target genes. May have a role in ventral epidermal patterning, independent of wg signaling.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Cytoplasmic in the half of the parasegment, posterior to the engrailed (en) domain, and nuclear in the half of the parasegment anterior to the en domain.
Sequence:
MDTSSAAGSGAGTGDVCPCSTVATSTTSASNEQPQTKRQKIEQQIKVGSKALPPQPPHPPDILDLDANSNSHLCSSLSSSSSHSLSTPSTANNSPTTTPCSSRAASYAQLLHNILPQNGDTDLHSQPESAHDEVDRAAKLPNLLTLDTTNGNGSHASSRSNCLQATTATSIDDMLEFEQSLTRQCLCGVSERTLRKPFQSHYSQDTNGQKRIAYLREWPTNKLLQFLSNLQLLFDIYLKQNAKGFICTRIMDVCDALIRNDHKLIDEIIVLAGYENSYVQFLAGRVLAAFLVIAKQELNDEWLQKIVDQLFNFEQLDQAAVQKIHFSLDIIKRIVEWKDMEIHPLDDDWMASANSTSAASSVVPLSTEASVSYMHFPVQEQPLATNYFALQFREDTEGERETGQEAPDNRDRHRRHFGEDMNVAYEPHPAPQSTTMPSGCHVVTLTDSESFDTTHLKCITIQKLEHKWPTLVKNMSELMAPTHQDAAEHCVLNFLQLWENIISVKANLSIDETRPYYAQLDKFELLLSHSLSCTVYKQMLCLFNEALCYGSTLALQDMLPEETCKLAHQIVCHVRGFRILESLPRRQPDNMVSLIGYNGKPMVYANGTITLAHAAQSGDSEEDGAPLDLIEMDKTLLQKMVLLVLKSIAVTVKEIRSDSSDSSIDSTDYDAFQDMMLIERSIRDVLSKLETFIKQTLEFHPECHFSKILIHLFDDQDDHLIEAMVCTLDVTSGISFRNNAFPELVAMLNPVYTFLEFLKMTSNSSDLLLDLLVSNETCFLLYLLRLLKYIRMNWTMFVHSCHTFGMGSAMLDEAMGVLIRLRLQISRLVSRQLYPYDISPVLRLLESCESLYEGNELS
The following text describes a protein:
Function:
Stimulates the secretion of gonadotropins. May be responsible for the regulation of the hypothalamic-pituitary-gonadal axis.
Subcellular Localization:
Secreted.
Sequence:
MAAKILALWLLLAGTVFPQGCCQHWSYGLSPGGKRDLDNFSDTLGNMVEEFPRVEAPCSVFGCAEESPFAKMYRVKGLLASVAERENGHRTFKK
The following text describes a protein:
Function:
Catalyzes the addition of isopentenyl diphosphate (IPP) onto dimethylallyl diphosphate (DMAPP) to form geranyl pyrophosphate (GPP). Is probably involved in the biosynthesis of decaprenyl diphosphate, which is required for mycobacterial cell wall synthesis. Could be required for host endothelial-cell invasion and/or intracellular survival.
Domain:
Contains two aspartate-rich motifs, designated as FARM (the first aspartate-rich motif) and SARM (the second aspartate-rich motif). Rv0989c contains arginine in place of the second Asp in its FARM and first Asp in its SARM. The primary role of the FARM and SARM is the chelation of the divalent magnesium ion cofactors that assist substrate binding and catalysis, but it may also play a role in determining product chain length.
Sequence:
MIPAVSLGDPQFTANVHDGIARITELINSELSQADEVMRDTVAHLVDAGGTPFRPLFTVLAAQLGSDPDGWEVTVAGAAIELMHLGTLCHDRVVDESDMSRKTPSDNTRWTNNFAILAGDYRFATASQLASRLDPEAFAVVAEAFAELITGQMRATRGPASHIDTIEHYLRVVHEKTGSLIAASGQLGAALSGAAEEQIRRVARLGRMIGAAFEISRDIIAISGDSATLSGADLGQAVHTLPMLYALREQTPDTSRLRELLAGPIHDDHVAEALTLLRCSPGIGKAKNVVAAYAAQAREELPYLPDRQPRRALATLIDHAISACD
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
Sequence:
MKNPCFSPFLCKRRKRTEDTIHRSVKMGSNNLPTTVDKEQIFGMAEKEMEYRVESFNKLTQTCFNKCVDRRYKDPELNIGENSCIDRCVSKYWQATNLIGQMLGNGRSPM