lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mS47 has enzymatic activity in vitro, and is able to catalyze the specific hydrolysis of 3-hydroxyisobutyryl-CoA (HIBYL-CoA). However, because the turnover rate of mS47/EHD3 is only a fraction of that of the homologous mammalian enzyme, the physiological function of this activity remains unclear. Has an indirect role in endocytic membrane trafficking.
Miscellaneous:
MISCELLANEOUS: Present with 3950 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MLRNTLKCAQLSSKYGFKTTTRTFMTTQPQLNVTDAPPVLFTVQDTARVITLNRPKKLNALNAEMSESMFKTLNEYAKSDTTNLVILKSSNRPRSFCAGGDVATVAIFNFNKEFAKSIKFFTDEYSLNFQIATYLKPIVTFMDGITMGGGVGLSIHTPFRIATENTKWAMPEMDIGFFPDVGSTFALPRIVTLANSNSQMALYLCLTGEVVTGADAYMLGLASHYVSSENLDALQKRLGEISPPFNNDPQSAYFFGMVNESIDEFVSPLPKDYVFKYSNEKLNVIEACFNLSKNGTIEDIMNNLRQYEGSAEGKAFAQEIKTKLLTKSPSSLQIALRLVQENSRDHIESAIKRDLYTAANMCMNQDSLVEFSEATKHKLIDKQRVPYPWTKKEQLFVSQLTSITSPKPSLPMSLLRNTSNVTWTQYPYHSKYQLPTEQEIAAYIEKRTNDDTGAKVTEREVLNHFANVIPSRRGKLGIQSLCKIVCERKCEEVNDGLRWK
The following text describes a protein:
Function:
Involved in protein precursor import into chloroplasts.
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein. Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MLVSCMLLVLLDNMFVLTRPKVSILKRHNPRYKSSVVALSSSLQANPMLSSNCGSQGFLSSTGPRCQALSALSSPFLGEDDDDLWRKTNVLPRRSRSPSFPRACKDDISKIRNPEKTEKPEWWLRTLACGPYLLALHISDAGYFLHPFLEHYEMFGNLIYFVPGAINRLPPWFSRIYCYFGYAGIVKNKALSRYIRIHLMMGMLLETAFKLIWYTGNFLPLTLFNGNFVMHFWAGIGIGYIFVLLECVRCALAGKYAHIPVISNAAYIHTRFNVGGFQRPS
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTTKTLTRPPVAPEVGSRPRASKWIWSWLYGGAFAVAALLLTVIGYLGAGLASGHVNWLELLTEKAWSPTSSVYGGLAMIYGTAVVSALALVIAVPISWAAAVALSEYLPPRLSRPLRMCVELLAAVPSIVYGLIGIMVVRPVIAQIADVPGGDSLAAAGIVLAVMITPTIVAVSVDALAAVPDRVRESAYSLGLTRREVVRSAVLPLARSGMRAAVLLGLARALGEAIAVFLVVGRADGRLPTSFGGFLDSLSHPGQTLTTKLAGPEPVLAGTSGPYFAALCALGLILLALVAAATIWGTRSRTRKNAAARTPRFRGTSRMRLQRDRLVMTLRLGALLLPSALLLGMLGLLVTRGSSAFNPSFWFSSATGAAGGGVRDQIVGTVLLILATGILALPLGFGAGILIGVHASERTARVLQTFTVVLGGAPTILLGLAGFVILSTSMGWGRSWLAGAIVLVPVVVPVIALTTSARVRSIPPELKESAMSLGLTRAQFVRSVVVPYTWPATITGLLLGLARAAGETAPLIFTATVFFGAPALPSGIVEAPVQALPTHIFTLSQDSGDPQAVTQAWGSAMVLVIITAVLLSAAVALRNRFEGERWTT
The following text describes a protein:
Function:
Mitochondrial arginine transporter that catalyzes the counter-exchange of arginine with lysine, ornithine, arginine, histidine and citrulline. Substrate preference in reconstituted proteoliposomes is arginine > homoarginine > citrulline > histidine > lysine > ornithine. May be involved in the delivery of arginine, released from seed reserves, to mitochondrial arginase and the export of ornithine. May contribute to proline accumulation in response to hyperosmotic stress.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MDFWPEFMATSWGREFVAGGFGGVAGIISGYPLDTLRIRQQQSSKSGSAFSILRRMLAIEGPSSLYRGMAAPLASVTFQNAMVFQIYAIFSRSFDSSVPLVEPPSYRGVALGGVATGAVQSLLLTPVELIKIRLQLQQTKSGPITLAKSILRRQGLQGLYRGLTITVLRDAPAHGLYFWTYEYVRERLHPGCRKTGQENLRTMLVAGGLAGVASWVACYPLDVVKTRLQQGHGAYEGIADCFRKSVKQEGYTVLWRGLGTAVARAFVVNGAIFAAYEVALRCLFNQSPSPDIVTGD
The following text describes a protein:
Function:
High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MYFRFGKGLQIQLRHSSKAVRSQLRWNSTTKLIKPIASTQHPFLVKPVTPHESYVSCTIFNEKGDVTAVSHKFPKWEFLQKYGLYPRDLRKIDSSTIDVIPSFVIKPKCILVNVLHIKAMIQKDKVFVFDTTNPDAAIKLGVLMYDLESKLSQRNINYQGKSVSYQENYEHRALESILINVMTCLETEYKYHHSVCGMILNDLENQIDRDKLRDLLIKSKTLTAFAQKSVLLRDLLDELLESDEDLAGMYLSEKKHPDADDHSDLEMLLETYYKQCDEYVQQSESLIQDIKSTEEIVNIILDANRNSLLLFELKVTVYTLGFTVATLVPAFYGMNLKNFIEDSNWGFASVVGLSVAAAAVVTITNMRALRSVTKLTLLNNHTGANNKKHLANAKLALDKEIPTFWDRWLTSARVLWSGREVLYKDGSKRDMIWKWLVDDDKK
The following text describes a protein:
Function:
Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs.
Subcellular Localization:
Peroxisome.
Sequence:
MERVDHLADERNKAEFNVDDMKIVWAGSRHAFDVSNRMSRLVANDPVFEKSKRAVMSRKELFKNTLRKSVHAWKLINELRLSDEEGLKLRSFMDQPGFLDLHWGMFVPAIKGQGTEQQQQKWLSLATKMQIIGCYAQTELGHGSNVQGLETTATFDPKTDQFIIHSPTQTSSKWWPGGLGKVSTHAVIYARLITNGKDHGVHGFIVQLRSLDDHSPLPGITVGDIGMKFGNGAYNSMDNGFLMFDHFRIPRDQMLMRLSKVTREGKYVASDVPRQLVYGTMVYVRQSIVSNASTALARAVCIATRYSAVRRQFGSHDGGIETQVINYKTQQNRLFPLLASAYAFRFVGEWLKWLYTDVTKRLEASDFATLPEAHACTAGLKSMTTSATSDGIEECRKLCGGHGYLWCSGLPELFAVYVPACTYEGDNVVLQLQVARFLMKTVSQLGSGKAPSGTTAYMGRAKHLLQCSSGVRNARDWLNPGMVLEAFEARALRMAVTCANNLSKFENQEQGFSELLADLVEAATAHCQLIVVSKFIAKVEGDIEGKGVKKQLKNLCYIYALYLLHKHLGDFLSTNSVTPEQASLANQQLRSLYSQVRPNAVALVDAFDYTDQYLGSVLGRYDGNVYPKLFEEALKDPLNDSVVPDGYREYIRPLIKQRFRSAKL
The following text describes a protein:
Function:
Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2); Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Secreted, extracellular exosome.
Sequence:
MIVLTVKTLDSQNHTFTVDDDITVEQFKTKIADTVNIPAETQRIIYCGRVLQDEAKLGDYDVNGKVVHLVQRPPPSQNPPTTRAASPQPPRRGFRGFDTENTMYLGSMAFPSNLMESQGIVPPPPTHSLAGSRLNVARRMLRRAEAVISLLENPSARPNEQATSEEQQEEEVTPIIEARVIVPPGNSDSIDEAMVLSAVQNTLFDAASGSIPMAAEVTIDGSGSSQNSSETPPAERSASSTPEEAAPTPTTSTTASEGTSGEQRNGGVSARTLAENASRTSEMAELLTTLNQLQTRFAPFLERYRHFMVEDPIIPQENVRQTQAMLTRVSEVLHFLGHAYHSLSDIIIRVRTPPPRPLLCRPILIQHSAVVQAGIPIQVEVAQFNLSERPNNTSTTTSSAATTTTTETSTNAGDGGARATLSAPQPSVNFRGFPFIPAASMRVQSFPIEVRTTARPVNVVHSTQRTQNNNNNNTVGASENRTPPTTTPPTTSSTFNMPNLNNSSVEFFMEVTPEVLQGTLNGPPPEFLQSLVQMAGQIMNRITTTAPTSDTNTTTTTSPTSNTDSAQSSQATPSQQTASGQNSQARGNTQTNPTTATHTRSTPRPHVHLAQQAMQGGFDPFLPCNSHHVTHRRRAQQATATPTVRQQQGSQATEGGEEGGEQRDRERAASQNLHSLFDEIYSTLRTAYRRRREGNNATGGGARSEGQSEGSGEEASGSTGQATGSGLGFGGGATAGTLPPSLANLLPNLQSTFANLPNMLQGPTIADILQQLPLDESSQENPGESIITDLIMLLSRNLTIVDMITLNTGNFEPLNRVTNEIQQFFTTRVLDGSNSPQAVNAGVDRFINEMQPFFQNFSRLRVNDDIDIVRSVETLFRRRLPDIITTATNLNSSNMRTLVDQCLTLAKMMCALTLTASANGQQGVEETFQQIITSYMQGIPTELQNWTMITSCANLHHFMANLGIDRSEVEPYIVRSTDVPMATPPDPTVQNESMELDEAEATVELPPLSLSDDSEPVPNIVLGSEPWHSQVPEDWVPIITRDVQRQRRQNTQPPFSDAYLSGMPTKRRKIVNSTKPQGSLPQVIAESVRRAVTVTGLSSVAPVEAVSQGAGESLDVQAAYRSLLRTTVQSALRDNEDFTPERFPNASTYFKTQ
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Sequence:
MASTTSLEDVPSMDMMTELLRRFKCSSKPDKRLILIGTLFYISFFQIMLTLPFRVCFEICKCFLELGFSSIVSSIIIILSPNYELKPRSRFHLQSYNFVEFRPTKVLGYNGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKETMEKGELVSDDLVVGIIDEAMKKPSCQKGFILDGFPRTVAQAEKLDEMLQKQGTKIDKVLDFAIDDSILEERITGRWIHASSGRTYHTKFAPPKVHGVDDVTGEPLMQRKDDTAEVLKSRLQAFHKQTKPVIDYYSKKGVVAMLPAEKPPKEVTVEVQKVLSS
The following text describes a protein:
Function:
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Subcellular Localization:
Cytoplasm.
Domain:
Lacks the C-terminal regulatory region which is replaced by HisZ.
Sequence:
MITLKNVKIALTKGRLEKKAIEIFKTININTRELEDKGRKLIFNCENEEYNIELFLVKAKDVETYVEYGAADIGIVGKDTLMETNKEFYEVLDLNVGKCKFALAALPSFKLDQGYNRKKIATKYPNIAREYFRKKGMDVELIKIEGSVELGPIVGLADAIVDIVETGNTLRENGLVVVEDICEISARMIVNKASMKTKKDEIIKIIENVSEVIRQ
The following text describes a protein:
Function:
Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MADAVVEEYESSLADLTFNSKPHINMLTMLAEENVKYAPHIVRLIEAQLNKATSSEKLPVMYLMDSIVKNVGGDYCTLFSQNIVSTFCNIFEQVDEKTRMSLYKLRSTWDTIFTSKKLYALDSRVQGIDPAWPVKPLPAEMQVSTSIHVNPKFLKKQESDTAAMQQQLQEQQEQLLREQLIAKQQELLKMQQARLEMELLQTRAKLDEQTKTLHTRPQVTPQPAVPLPSFSQVATSLPTTSVPTSAARDPRLASRDPRLARQPASQPASTMPQYNTGAFPSTSMAAQSWLASGTHSPVPQPLVGGAGPLAERISANQQKRGGEPIIVPVAQPALDETSSTEKKPAQQKVQKPQEKAKTKTETKVSSPKKSSTSAKDQKGKDTKSKDNKDKTKKDDSKSKPAAKTEKKDDKKKDEKKPDPKSTRGKRNYRTRRSDEDNKDDKDSKSRDSKDKKDEQKSRNEKTRTSSGSSSSRRGSRSSPDRSTRRRSTSKSSSHSPRAKSRSRSPVRRHSSRSISPKERRSSRSGRQDRTPPRSSRTTHESSKDKDDKAKAKTSDTKSKAGTKRSMEKENKSKIKKEPQEAKPGNKYEQSQDYGIGSPKFSPEPESDAEEPVPKRFRLADRDFPRRAWPLPLQSNVRQEPRARRPSISSLPRIPRKPAGTPTRRMSIDPDLKIPKELTLEKQQQILKQAEQQFRTGELTHQQYQEMLKQLHVLYELQRQRQEQMQQQDGQVNRVERREDCVRGGRMGRGRGRGLLPTPPSPWAELKRQPSVEAKSPWAEYKKSHPSERDFQFPVKEEKDGASDQAQQAYLEHRKKLEERKSYLEHKNKLRKTPLYLERRQDYPFRDFPMDVDERQGAAGHGRGREGVGFEGMHRRALLPYLGQQDGSPRPSDDGRREDPRLRRADDRGAPDFRGEEDRRRWEEWKKFDDQVCKQWNFEYRKWEEEIKKWEDSGRQGARPLAPHEVYGRGKQEFDPKKEEEYRRWQDDIRRWEQDGRNGPPPPAPQESLPLGPELLERLENDRRQWAEERAKFLKELNIWEQKMERWKKFGNGPPPQRPQEPEHRGLPVDRRWEEDRQRFENELRKWDADMAMWEKNGRRGAPPLRPKEPSLPTSTPVVFMERQGFPPDSQFDRPSRTWEEDHRRWEEDMCRWEQGGRKGQPPQEPLRPPQFDQPNQRLEDHRRREHEGRKGQFERWQDDHRRWEEDMRRWEQDGRKGQPPQEPLPPLQFDKAELEAEHRRWHESRGRFEAELKKWEENGRRAPPPPSHMDMPPPLGPEMPEVARKQWTLDCQHWQDQMRGWEQGGRQGPPPSPPYHLLSQALEINDAARRQWEEDHRRWEEDMKRWEADGRRGLPPQEPVMQMPGAQQHLSALQKPEPEWREFEDKRRQWEEEMRRWEAGGRRGAPPAEPVPPRVQSPGIQNRNSQWEEDHRKWQDDMKRWELDGRRGLPPIEPIHPSNQGQQGPAAAQREWEQRHRRWQEDMRRWEADGRREMPPPEPQPPRLEEDPRREVALREWESNCRQWEEDMRRWEEGGKRGAQPIKPILHLPQANVALIEWEAQHRRWKEDMQRWEMDGRRGVPPTEPLRPPAPDHHPDNSHQTFQDRHRMWEQDMDRWEKGGRKGQAPLEPLPPLPPKNVLSEEERKKLDEEHHMWEEAMTRWVEGGRMGPPPPAPGEQEEVPRPLIPGLSGARMGGPRMDGPGPGPRMDGLGPRMDGPGPRMDGHGPRMDGPGPRMDGPGPGPRMDGPGPGPRMDGPGPLPRMDGPGHRMDGPGHRMPGPGFRMDGPMQRPGQFGMMQPGLVSSAAGPIMSGPGPIMSGPMGGMPFSGPGPANVFGNMVMGVATTMQLAMGGMGMTGQPMQGRPPMQPMPGPSHMSMGPMPGIPVHHPPMGFGMAPPPAPGPSLQPAKLDVNQLFEKLLKTGIIKKVDEKKEEPKVEEKTVEAKKEEKTRVVVPLEERMEEDEPRAELKLDTTVPPLTLRVEDLKTRHKGVINRLYCGIQCSSCGSRFLPEETDKYANHLDWHFRMNRREKEGTGKASHRDWYYGVDDWIAYAELGDDEEVQESAFFEQPVLPTSEPGEVISCPVCTDEENDDICDICQEPFEQFWDEDEEAWHLKDAVRVNGKTYHPNCYEDYDESFLETPTPADAPKESPLEAQIKMETNAEEAVQVKEEPMDTAEEEEKPSTSAMQPLSTIKEIPFLSEEAKEQTNIKEEVSENMEVGETEQVKTETPDIEVKEEPKSPLGNQCEAMVPAQVDNVTIKQEPEEENGPAQPDNDNEQTTDQIAVKQEVVDNPVKTEPPTPVSVKKEVEEENVSTAVKEESVTENVKVERVSPSPMEVPLVEPKVEQVDENRGQAISTIGGGTKIPVVGGASPLRGSAISVVGGGSSPARFRSNSPMRSIPVIGASSSPNRTGQSTAKSETAQKPKTGSFFKLDPSAKTK
The following text describes a protein:
Function:
Binds to membranes enriched in phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin.
Miscellaneous:
MISCELLANEOUS: Present with 1970 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein. Note=Localizes in a punctate pattern. Found in the actin cortical patches, although the majority is located at the cell periphery.
Sequence:
MSKQFVRSAKNMMKGYSSTQVLVRDATANDSRTPSIDTLDDLAQRSYDSVDFFEIMDMLDKRLNDKGKYWRHVAKSLTVLDYLVRFGSENCVLWCRENFYVIKTLREFRHENESGFDEGQIIRVKAKELVSLLNDEERLREERSMNTRNRRANRAARPRPRRQRTRSNPHDSSPSYQDDLEKALEESRITAQEDEQRRRELAQYDDEDPDFQAALQLSKEEEELKQLQELQRLQKQQQSLSQFQAPLQQQQPQQQPAYYDIFGNPISQDEYLQYQYQQDQEQAMAQQRWLDQQQEQQQLAEQQYFQQQQQAAAAASALQQQQTAANMQQQQQQPADFQQPLPTGSNNPFSMDNLERQKQEQQHAQLQRQQEEARQQQEQLKLQQLQRQQQEEAQLHQKRQEEAQLQQQQAQLLQQQAQFQQQQPLKQTRTGNQSISDKYSDLNTLLATGTGIDTFGNTGEARIPAQHTKTGTFINSQGTGYKQVTNEPKNNPFLSNQYTGLPSTNIVPTQTGYGFGNQPQSPPTNSPQQNPTGISYSQPQQQQQPQQQPQYMQNFQQQQPQYAQNFQQQPQYTQNYQQQPQYIQPHQQQQQQQQQQQQQQGYTPDQGVSLIDL
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKEDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEKQLRQHKASLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQSQ
The following text describes a protein:
Function:
Vacuolar Fe(2+) uptake transporter.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MVHHYRCYLHIIVSLLYCLVDIYTGSCVRHTLVCFCACGTRTPLLPHKMATDNDTKLAVAELGPTPAPEAMKLCTVCVATATHDAMSLPSQQGQWLRAAVLGASDGLVSTSALMLGIGAARPADPRAALLSGVAGLVAGACSMAIGEYVSVHAQLDVELAGLKRLEEARGYPADRAGLPNPCHASAASALSFAAGAAIPLLAAWFVTSYGVRVAVVVATATLALAVFGALGAVQGRAPGGRAGLRAALGGLVAMGVTYGLMKLFRTHSD
The following text describes a protein:
Function:
Component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes (CRLs), which mediate the ubiquitination of target proteins. The CRL associates with CDC34 as the E2 ubiquitin-conjugating enzyme. The functional specificity of the CRL depends on the type of the associated substrate receptor protein. RTT101(MMS1-MMS22) promotes fork progression through damaged DNA or natural pause sites by stabilizing replication proteins like the replication fork-pausing complex (FPC) and leading-strand polymerase at stalled replication forks. RTT101(MMS1-MMS22) ubiquitinates the acetylated histones H3K56ac-H4 at lysine residues H3K121, H3K122 and H3K125. Ubiquitination is required for efficient histone deposition during replication-coupled nucleosome assembly, probably by facilitating the transfer of H3-H4 from ASF1 to other chaperones involved in histone deposition. RTT101(MMS1-CRT10) may regulate nucleotide synthesis through transcriptional regulation of ribonucleotide reductase. RTT101(MMS1) is also involved in the non-functional rRNA decay (NRD) of 25S rRNA through the selective, ubiquitination-dependent degradation of nonfunctional ribosomal particles. Involved in the regulation of TY1 transposition.
Subcellular Localization:
Nucleus. Note=Enriched on chromatin at sites where replication forks have stalled.
Sequence:
MLGLRTHGLDRYEHYIRRPSDFGKLELQDWLNHKSFRVSPNLLIDSSTTREWNEPELFYQNTEDETWVRPCVGPKLEPSMMMLRYHDSNIGQMPQFCYPISSPINFKPVLKYILQERSELSDGFPQKYNTLIGSLFDIDKNPETLDDSDIEALDDIEMSSDSGNVKEPKIELQALEEIQQKHFSLIVSNNGIFQTGSTSITYIQSGISGSIAIKPNNVAILILLTQPSGHLLSILPLDDGKETYLLQYWNLGQKGQWNIIKHQNEKQFVLIHKELGICKFFEFHLPFTFQLVNNLTLTDSVIMNGSFFPTNYTDLDPYFIIFITAIRYERIVYFVIEWNNNEIKKKEVYQLTVFDGEKTNMTIPIGLNACLVETPLKFSLVSANQIMSGETEFHSFQLKALKGIKSFFPAPLLLLKLQELHPHTFKKFQYCTIISSSTGNICFCVTERSTIVNGNLKFYELTRFKGLKSISPLPSNPINLDSRSSSYVLVVISFSRTLELTLSLEDLRCLDKKDVIKPLKNITFKHTIDSSTEENSQILAFTSSKFYNTHTGSNINDTRNSQVWLTSPNAITQPCIDYKLRKTHQLIHLKQFQIFRHLRIWKCKNLDIALLQRLGINQSNTESSLIFATDAVSNNRIFLLDLTMTTTIDNDDPVQGLINIEDLLCDTENETILLNFTKNNLIQVTRDTIYIDPIGGDKELRKISPGWEFENVTYNDGILIVWNAGLGCVSYIENIDAVDESGALVSNLSSSKGMSKFFKQLGTVTSVNFQIKESTDDPTKYDIWILLPDCVIRTPFSDWISDSLDFSDVYILSVQQALINGPYFCSLDYESYFEVHTLQNNCFKKGSRCTSRVNFQGKDIKFRSFGVNQCLAFSAFEIFVINLTPIHDSRELDFYKLKLPHLGNNNSILEVCPDIENNQLFILYSDGLRILELSYLTSNNGNFLLKSTRSKNKKFLYLDKINRMLVLNQDLREWECIRLSDGKAVGLDSQLLKDDSEEILEIKELPIATEDNPLEKKTVLLISFTSSLKLVLLTAAKNKISNQIIDSYKLDNSRLLNHLVITPRGEIFFLDYKVMGTDNEMSFNKLKVTKHCIDQEERNNTTLRLTLETRFTFKSWSTVKTFTVVGDNIIATTNMGEKLYLIKDFSSSSDESRRVYPLEMYPDSKVQKIIPLNECCFVVAAYCGNRNDLDSRLIFYSLPTIKVGLNNETGSLPDEYGNGRVDDIFEVDFPEGFQFGTMALYDVLHGERHVNRYSEGIRSENDEAEVALRQRRNLLLFWRNHSSTPKPSLRRAATIVYEDHVSSRYFEDISSILGSTAMRTKRLSPYNAVALDKPIQDISYDPAVQTLYVLMADQTIHKFGKDRLPCQDEYEPRWNSGYLVSRRSIVKSDLICEVGLWNLSDNCKNTV
The following text describes a protein:
Function:
May be a negative regulator of the ABA signaling/synthesis pathway.
Sequence:
MNFISDQVKKLSSSTPEEPDHNKPVEGTETATRPATNAELMASAKVVAEAAQAAARNESDKLDKGKVAGASADILDAAEKYGKFDEKSSTGQYLDKAEKYLNDYESSHSTGAGGPPPPTSQAEPASQPEPAAKKDDEESGGGLGGYAKMAQGFLK
The following text describes a protein:
Function:
Receptor for basic fibroblast growth factor.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MILNIWYLFAFATCTKALISNPHTSSNQTEDNAPYFTKRNLPVLVSGRQGQSSILKCGAKGTPKPQISWYKGTNLITQSNKKYHLIHQNLKILNLQSEDNGLYKCLVCNEVSCIHHNYNLVVEPFYAKSFANNDLEEKTTSDSFRTQKVKLHFRRPNKMPKTLSVRINRRVILNCRTFGTPSPTISWYKNGEALAKSRRKIVQSRWSMLVKNFNRGDSGNYTCVACNSMDCINHTFTLSTKELCGSNAIYSKKSAVVSGSNVTLACRAGAAWVRTYPNGTNQVIKNNTRCLNIDNISQEDEGWYRCQRVSWYLTVIDSEEEENTVPASSLRKKRETEKKAPYWVNPKKMSKMQVKPAGNMVNLKCKAGGNPTPNITWYKDDKPPNRQLGDIRYQHWSLTLEDLVTGDTGDYTCVVCNELGCINFTYRVDVIERYHNKPVLTHPLENTTAVVGTSINLTCTFLADLNPFIQWTREYPNKSAVVVLQKSGDTDSPEVYEIKNVTYQDEGWYVCIAANSLGQTASKGYLKVVDSLEVEPKNNYIVYTALIIFFTIIAFGTLVLLFFRKLKIEKQKKMIDIETVRAAVVTQWTKKVIIEKIQNTNEDVSEPLLMPVVKIEKQKSQNNNSGDGMISEYELPMDSDWEIPRSMLCLGKSLGEGAFGKVVKAEAVGLLKPGASSIVAVKMLKEGHTDNEMMDLVSEMEMMKMIGKHNNIINLLGCCTQGGPLYVVVEYAPYGNLRDFLRQHRPSSGYEPAIGLEEKEKKTLTQKDLVSFAYQVARGMEYLASRRCIHRDLAARNVLVSDDYFLKIADFGLARDIHCNDYYRKTTDGRLPVKWMAPEALFHRVYTTQSDVWSYGILLWEIMTLGGTPYPSVPSVEKLFQLLRNGHRMEKPPCCSLEIYMLMRECWSYKPNERPTFSQLVEDLDRILTITANEEYLDLGLPQLDTPPSSQESSGDEEDFPFDSLTSQCLNNVQLS
The following text describes a protein:
Function:
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSAPKSFHLCDNIGCHCWNGDATKIAYSPCSKEIIVASFDGNKFTTEAKLNEHDARVTGIDWAAQSNRIVSCSEDRNAYVWTQNENGEWVPVLVLLRIDFAATDIKWSPNESKFACASGNKLVAVCRFNEESNWWASDHVKKFKSTVTKVAWSPDSLTVAAASTDFKARIFNAFNKTLDPKGSYSPFSEEDISSPKCKFGTFLFETEANGWVHSVAYTPSGTTVVFVSHDSSISFIEANNGKPTVQTIKCKTLPFLDVLCISDNKVVAVGHHFNPCLFERGDDGWKFVKELDQKQAPKSTGTMSAMDHFKSLSSRGTAAVKSAVEEITTTHKNTVTCIRPMKYDEAWNVLEFSTSGMDGNIAIWKA
The following text describes a protein:
Function:
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MECLFGFVGDGFALVVADTCANQSIVVQKTTEDKITCLDSHKLLGCIGESGDRVQFSNFIQKNMNLYHFRNGIPLSTSAAASFTRCELATALRKAPYQVNMMMAGYDKRTGPCLFYLDYIATLQKLNKGAQGFGAYFILSLFDKYYQKNMNVEEALQLVDKCIWEIGTRMVASPANYVIKIVDRNGARLLARRGRNMSPNLPYAKIS
The following text describes a protein:
Function:
Catalyzes the production of D-threo-tetrahydrobiopterin (tetrahydrodictyopterin or DH4), also known as dictyopterin, and in a much smaller amount that of it's stereoisomer L-erythro-tetrahydrobiopterin ((6R)-L-erythro-5,6,7,8-tetrahydrobiopterin or BH4). Prefers 1-oxo-2-D-hydroxypropyl-tetrahydropterin to 6-pyruvoyltetrahydropterin (6-pyruvoyl-5,6,7,8-tetrahydropterin) as a substrate, thereby maintaining dominant production of DH4 over BH4 in sufficient supply of an aldose reductase-like enzyme. DH4 represents more than 95% of the total tetrahydrobiopterin production. It has a direct antioxidant function to protect mitochondria against oxidative stress. Essential for the last step of BH4 synthesis. Also catalyzes the conversion of sepiapterin to L-erythro-7,8-dihydrobiopterin, which is then reduced to BH4 by dihydrofolate reductase, constituting the salvage pathway of BH4.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKVLAIVTGASKGFGKAIAQEIVKCNPNKNQLIDLVLFARSLDGLKSTKESIETISTNAKVIDLQSLDMSNIPDVELKFKSVLENIKWEEYSKICFFNNHGTLYHLGRIEDFSDFKNIQKDNDTNTTSFVVTTSLLVKKLKELGSQYSSEVTIVNSSSLCAIKAFPTWSLYCSSRAYRDMFFQALSLEYKLNDKFKVLNYSLGVLDTDMQSQVREECSEDDKSFYVGLKNDGKLINPNRSASICSNLVYSHKFETGSHLDYYDLDK
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds to GA-rich elements (GAGA-repeats) present in regulatory sequences of genes involved in developmental processes.
Subcellular Localization:
Nucleus.
Sequence:
MDDDGSLSIRNWGFYETMKGNLGLQLMPSVTGGHRDTKPLLPNGTFLQHHTPPHHPPHSHHPRDYGNGEPSGGMPAEPPAIHMDFVRNEAWMHPSQHQHQHQHQHQHQHQHQHQLQHQHQHQHSRELKVLNAVPVGPAPHIGHPGHAVHHHPTGFGMMPDARGAHTLQMMQPQEPPVPDEEKITPPLVEDHSVVGSKPPVKKRQQGRQPKVPKPKKPKKDATPGEDGAPKARAPRSRGPLKPVEMVINGIDFDISRIPTPVCSCTGAPQQCYRWGAGGWQSACCTTSISTYPLPMNTKRRGARIAGRKMSQGAFKKVLEKLAGEGYNLNNPIDLKTFWAKHGTNKFVTIR
The following text describes a protein:
Function:
May mediate microtubule plus end-directed vesicle transport.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome. Endosome. Lysosome.
Sequence:
MASTNAESQLQRIIRDLQDAVTELSKEFQEAGEPITDDSTSLHKFSYKLEYLLQFDQKEKATLLGNKKDYWDYFCACLAKVKGANDGIRFVKSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLQPKLSSDIVGQLYELTEVQFDLASRGFDLDAAWPTFARRTLTTGSSAYMWKPPSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLQERMQQLDRENQELRAAVSLQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQAIQNTVKELQTCLQALELGAAEKEEDYHTALRRLESMLQPLAQELEATWDSLGKKNQHLASFPGCLAMAQQKADTASDTKGRQEPIPSDAAQEIQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGTLERLAGPPGPELPVAGEKNEALVPVNSSLQEACGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEATLQSKEGECQQLREEVEQCRHLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEAQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEKLRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTMEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELDTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSTHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHCRICGRIFCYYCCNNYVLSKHSGKKERCCRACFQKLSEGPGSPDSSGSGTSQGEPSPALSPASPGPQATGGQGANTDYRPPDDAVFDIITDEELCQIQESGSSLPETPTETDSLDPNVAEQDTTSTSLTPEDTEDMPLGQDSEICLLKSGELMIKVPLTVDEIASFGEGSRELFVRSSTYSLIPITVAEAGLTISWVFSSDPKSISFSVVFQEAEDTPLDQCKVLIPTTRCNSHKENIQGQLKVRTPGIYMLIFDNTFSRFVSKKVFYHLTVDRPVIYDGSDFL