lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp.
Subcellular Localization:
Nucleus.
Sequence:
MEMESDNSDDEGSIGNGLDLTGILFGNIDSEGRLLQDDDGEGRGGTGFDAELRENIGSLSKLGLDSMLLEVIDLKEAEPPSDDEEEEDARPSAVSASEGMSAFDALKAGVKREDGAVKAQDDAIDYSDITELSEDCPRTPPEETSTYDDLEDAIPASKVEAKLTKDDKELMPPPSAPMRSGSGGGIEEPAKSNDASSPSDDSKSTDSKDADRKLDTPLADILPSKYQNVDVRELFPDFRPQKVLRFSRLFGPGKPTSLPQIWRHVRKRRRKRNQSRDQKTTNTGGSDSPSDTEEPRKRGFSLHYAAEPTPAECMSDDEDKLLGDFNSEDVRPEGPDNGENSDQKPKVADWRFGPAQIWYDMLEVPDSGEGFNYGFKTKAASTSSQPQLKDERRVKSPEDDVEDPSIADDAFLMVSQLHWEDDVVWDGNDIKAKVLQKLNSKTNAAGWLPSSGSRTAGAFSQPGKPSMPVGSGSSKQGSGASSKKAQQNAQAKPAEAPDDTWYSLFPVENEELIYYKWEDEVIWDAQQVSKVPKPKVLTLDPNDENIILGIPDDIDPSKINKSTGPPPKIKIPHPHVKKSKILLGKAGVINVLAEDTPPPPPKSPDRDPFNISNDTYYTPKTEPTLRLKVGGNLIQHSTPVVELRAPFVPTHMGPMKLRAFHRPPLKKYSHGPMAQSIPHPVFPLLKTIAKKAKQREVERIASGGGDVFFMRNPEDLSGRDGDIVLAEFCEEHPPLINQVGMCSKIKNYYKRKAEKDSGPQDFVYGEVAFAHTSPFLGILHPGQCIQAIENNMYRAPIYPHKMAHNDFLVIRTRNNYWIRSVNSIYTVGQECPLYEVPGPNSKRANNFTRDFLQVFIYRLFWKSRDNPRRIRMDDIKQAFPAHSESSIRKRLKQCADFKRTGMDSNWWVIKPEFRLPSEEEIRAMVSPEQCCAYFSMIAAEQRLKDAGYGEKFLFAPQEDDDEEAQLKLDDEVKVAPWNTTRAYIQAMRGKCLLQLSGPADPTGCGEGFSYVRVPNKPTQTKEEQESQPKRSVTGTDADLRRLPLQRAKELLRQFKVPEEEIKKLSRWEVIDVVRTLSTEKAKAGEEGMDKFSRGNRFSIAEHQERYKEECQRIFDLQNRVLASSEVLSTDEAESSASEESDLEELGKNLENMLSNKKTSTQLSREREELERQELLRQLDEEHGGPSGSGGAKGAKGKDDPGQQMLATNNQGRILRITRTFRGNDGKEYTRVETVRRQPVIDAYIKIRTTKDEQFIKQFATLDEQQKEEMKREKRRIQEQLRRIKRNQERERLAQLAQNQKLQPGGMPTSLGDPKSSGGHSHKERDSGYKEVSPSRKKFKLKPDLKLKCGACGQVGHMRTNKACPLYSGMQSSLSQSNPSLADDFDEQSEKEMTMDDDDLVNVDGTKVTLSSKILKRHGGDDGKRRSGSSSGFTLKVPRDAMGKKKRRVGGDLHCDYLQRHNKTANRRRTDPVVVLSSILEIIHNELRSMPDVSPFLFPVSAKKVPDYYRVVTKPMDLQTMREYIRQRRYTSREMFLEDLKQIVDNSLIYNGPQSAYTLAAQRMFSSCFELLAEREDKLMRLEKAINPLLDDDDQVALSFIFDKLHSQIKQLPESWPFLKPVNKKQVKDYYTVIKRPMDLETIGKNIEAHRYHSRAEYLADIELIATNCEQYNGSDTRYTKFSKKILEYAQTQLIEFSEHCGQLENNIAKTQERARENAPEFDEAWGNDDYNFDRGSRASSPGDDYIDVEGHGGHASSSNSIHRSMGAEAGSSHTAPAVRKPAPPGPGEVKRGRGRPRKQRDPVEEVKSQNPVKRGRGRPRKDSLASNMSHTQAYFLDEDLQCSTDDEDDDEEEDFQEVSEDENNAASILDQGERINAPADAMDGMFDPKNIKTEIDLEAHQMAEEPIGEDDSQQVAEAMVQLSGVGGYYAQQQQDESMDVDPNYDPSDFLAMHKQRQSLGEPSSLQGAFTNFLSHEQDDNGPYNPAEASTSAASGADLGMDASMAMQMAPEMPVNTMNNGMGIDDDLDISESDEEDDGSRVRIKKEVFDDGDYALQHQQMGQAASQSQIYMVDSSNEPTTLDYQQPPQLDFQQVQEMEQLQHQVMPPMQSEQLQQQQTPQGDNDYAWTF
The following text describes a protein:
Function:
Probable methyltransferase.
Sequence:
MIPNNINNRKKLKLPELFKEKYGFNKKGIELRYCDGEKGMGIFSNRKFNKGEKIMKIEPYVWSVAKHAIVCDECLKNKLDLEEGKTLKRCSNCKLVYYCSTDCQTKAWKIHKQECKILSTIPSTTDKKNINTKSTTMLLRLFIKRNLELINNNNNNNNNNNNNNNNNDNHITGQYEIIDGLLNHKDIRSDNNEYKSFSSGFCSLLGEDPQLKAPIVLEYLLKLEPNCITIPRCEASSIGLYPLMLFFNHSCKPNISIINNRKELLIITNKIIEKDEELFINYSPAICYRNERLDNLKQCFFFNCKCTLCLGEEKIKSKDLYITCNINNCGGRINQEIDININNNNNNNNNNNNNSNNNNNNNNSNEEILKCYKCLKVYKGQEKDEILKKKLIIKNLQNKLSTNTDQININQEFKSLLELYCKEIHPTDPLFYEIVNKTQLFYLGNNNKFISDNELSTIYHPRYQIMIKYHLLQVQNLEYEYCRQMLDYVNTLATTSYFKDALNILTDLMSNHLSQIDFYGFNRDELLSLLYNLQHEYKNNIKTSRKIIN
The following text describes a protein:
Function:
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular Localization:
Cytoplasm.
Sequence:
MIQSSLYRALNKGFDYQILACKDFKESELAKEVISYFKPNTKAILFPEFRAKKNDDLRSFFEEFLQLLGGLREFYQALENKQETIIIAPISALLHPLPKKELLESFKITLLEKYNLKDLKDKLFYYGYEILDLVEVEGEASFRGDIVDIYAPNSKAYRLSFFDTECESIKEFDPITQMSLKEDLLEIEIPPTLFSLDESSYKDLKTKVEQSPLNSFSKDLTSFGLWFLGEKAQDLLIVYKSIISPRALEEIQELASLNELDCERFKFLKVLENAQGYEDLEIHAHALEGFIALHSNHKITLLAPNKTILDNAISALDAGNMECVIAPFVLNFKTPDGIFISLNSFERKKKRQKSKLALNELNPGEWVVHDDYGVGVFSQLVQHSVLGSKRDFLEIAYLGEDKLLLPVENLHLIARYVAQSDSVPAKDRLGKGSFLKLKAKVRTKLLEIASKIIELAAERNLILGKKMDVHLAELEVFKSHAGFEYTSDQEKAIAEISKDLSSHRVMDRLLSGDVGFGKTEVAMHAIFCAFLNGFQSALVVPTTLLAHQHFETLRARFENFGVKVARLDRYASEKNKLLKAVELGQVDALIGTHAILGAKFKNLGLVVVDEEHKFGVKQKEALKELSKSVHFLSMSATPIPRTLNMALSQIKGISSLKTPPTDRKPSRTFLKEKNDELLKEIIYRELRRNGQIFYIHNHIASILKVKTKLEDLIPKLKIAILHSQINANESEEIMLEFAKGNYQVLLCTSIVESGIHLPNANTIIIDNAQNFGLADLHQLRGRVGRGKKEGFCYFLIEDQKSLNEQALKRLLALEKNSYLGSGESVAYHDLEIRGGGNLLGQDQSGHIKNIGYALYTRMLEDAIYELSGGKKRLEKSVEIQLGVSAFLNPELIASDSLRLDLYRRLSLCENTDEVGQIHEEIEDRFGKIDDLSAQFLQIITLKILANQLGIIKLSNFNQNITITYSDEKKESLKAPSKDDNDILETLLKHLRAQISLKRR
The following text describes a protein:
Function:
Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH.
Sequence:
MEGFAGKVAVVTGAGSGIGQALAIELARSGAKVAISDVDTDGLADTEHRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNAGIAFTGDIEVSQFKDIERVMDVDFWGVVNGTKAFLPHLIASGDGHVINISSVFGLFSAPGQAAYNSAKFAVRGFTEALRQEMALAGHPVKVTTVHPGGVKTAIARNATAAEGLDQAELAETFDKRVAHLSPQRAAQIILTGVAKNKARVLVGVDAKVLDLVVRLTGSGYQRIFPIITGRLIPRPR
The following text describes a protein:
Function:
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Domain:
The fibrinogen C-terminal domain mediates interaction with CSPG5.
Sequence:
MGLPSQVLACAILGLLYQHASGGLIKRIIRQKRETGLNVTLPEDNQPVVFNHVYNIKLPVGSLCSVDLDTASGDADLKAEIEPVKNYEEHTVNEGNQIVFTHRINIPRRACGCAAAPDIKDLLSRLEELEGLVSSLREQCASGAGCCPNSQTAEGRLDTAPYCSGHGNYSTEICGCVCEPGWKGPNCSEPACPRNCLNRGLCVRGKCICEEGFTGEDCSQAACPSDCNDQGKCVDGVCVCFEGYTGPDCGEELCPHGCGIHGRCVGGRCVCHEGFTGEDCNEPLCPNNCHNRGRCVDNECVCDEGYTGEDCGELICPNDCFDRGRCINGTCFCEEGYTGEDCGELTCPNNCNGNGRCENGLCVCHEGFVGDDCSQKRCPKDCNNRGHCVDGRCVCHEGYLGEDCGELRCPNDCHNRGRCINGQCVCDEGFIGEDCGELRCPNDCHNRGRCVNGQCECHEGFIGEDCGELRCPNDCNSHGRCVNGQCVCDEGYTGEDCGELRCPNDCHNRGRCVEGRCVCDNGFMGEDCGELSCPNDCHQHGRCVDGRCVCHEGFTGEDCRERSCPNDCNNVGRCVEGRCVCEEGYMGIDCSDVSPPTELTVTNVTDKTVNLEWKHENLVNEYLVTYVPTSSGGLDLQFTVPGNQTSATIHELEPGVEYFIRVFAILKNKKSIPVSARVATYLPAPEGLKFKSVRETSVQVEWDPLSISFDGWELVFRNMQKKDDNGDITSSLKRPETSYMQPGLAPGQQYNVSLHIVKNNTRGPGLSRVITTKLDAPSQIEAKDVTDTTALITWSKPLAEIEGIELTYGPKDVPGDRTTIDLSEDENQYSIGNLRPHTEYEVTLISRRGDMESDPAKEVFVTDLDAPRNLKRVSQTDNSITLEWKNSHANIDNYRIKFAPISGGDHTELTVPKGNQATTRATLTGLRPGTEYGIGVTAVRQDRESAPATINAGTDLDNPKDLEVSDPTETTLSLRWRRPVAKFDRYRLTYVSPSGKKNEMEIPVDSTSFILRGLDAGTEYTISLVAEKGRHKSKPTTIKGSTEEEPELGNLSVSETGWDGFQLTWTAADGAYENFVIQVQQSDNPEETWNITVPGGQHSVNVTGLKANTPYNVTLYGVIRGYRTKPLYVETTTGAHPEVGELTVSDITPESFNLSWTTTNGDFDAFTIEIIDSNRLLEPMEFNISGNSRTAHISGLSPSTDFIVYLYGISHGFRTQAISAAATTEAEPEVDNLLVSDATPDGFRLSWTADDGVFDSFVLKIRDTKRKSDPLELIVPGHERTHDITGLKEGTEYEIELYGVSSGRRSQPINSVATTVVGSPKGISFSDITENSATVSWTPPRSRVDSYRVSYVPITGGTPNVVTVDGSKTRTKLVKLVPGVDYNVNIISVKGFEESEPISGILKTALDSPSGLVVMNITDSEALATWQPAIAAVDNYIVSYSSEDEPEVTQMVSGNTVEYDLNGLRPATEYTLRVHAVKDAQKSETLSTQFTTGLDAPKDLSATEVQSETAVITWRPPRAPVTDYLLTYESIDGRVKEVILDPETTSYTLTELSPSTQYTVKLQALSRSMRSKMIQTVFTTTGLLYPYPKDCSQALLNGEVTSGLYTIYLNGDRTQPLQVFCDMAEDGGGWIVFLRRQNGKEDFYRNWKNYVAGFGDPKDEFWIGLENLHKISSQGQYELRVDLRDRGETAYAVYDKFSVGDAKTRYRLRVDGYSGTAGDSMTYHNGRSFSTFDKDNDSAITNCALSYKGAFWYKNCHRVNLMGRYGDNNHSQGVNWFHWKGHEYSIQFAEMKLRPSSFRNLEGRRKRA
The following text describes a protein:
Function:
Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MNFSLNFTTRNLVPRLHRFTSKIAVDVEPAVVSALEHATLKPRKHPGVVRPNHVELPKQLNDTLKRIVGDHPVKKLIHDGQQLNAYIKSRHPPPTLEEIENKKRIVIEEVNTKMPLDRLATLDEDEAERWRRKRELEINKRLGQRIYAWKRIEYGAYESLVYAIARGAQEYAVLKRVLTELAQRDEQFRPRSFFDFGSGIGTGMWVASELWREHIFEYYNVDRSREMNEISELILRDGHENKQIALRNVFYRQFLPAIETNYDLVIISHTLFELENKEQREDVLRNLWRKCDGYLVIVEEGTRRGSELVNEARQFLLEQEQEGHTVAPCPHDLVCPRLRDLADRTPCNFPISYAPLRLGSDFLADRHTSLYSYAILKKGSQSDSSSSWPRIVRPTLVRSKHAICRLCTEKGTLQEVIFTKSKHGKSAYSCAKVSRWGDRLPMSLGQPQIKQESIESEEPPVLA
The following text describes a protein:
Function:
Required for processing of 5.8S rRNA (short form) at site A3 and for 5'- and 3'-processing of pre-tRNA.
Miscellaneous:
MISCELLANEOUS: Present with 1360 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSGSLKSLDKKIAKRRQVYKPVLDNPFTNEAHMWPRVHDQPLIWQLLQSSIINKLIHIQSKENYPWELYTDFNEIVQYLSGAHGNSDPVCLFVCNKDPDVPLVLLQQIPLLCYMAPMTVKLVQLPKSAMDTFKSVSKYGMLLLRCDDRVDKKFVSQIQKNVDLLQFPWLNAIKYRPTSVKLLKTTVPIVSKKRQK
The following text describes a protein:
Function:
Acts with RNA polymerase to initiate transcription from intermediate gene promoters.
Sequence:
MFEPVPDLNLEASVELGEVNIDQTTPMIKENSGFISRSRRLFAHRSKDDERKLALRFFLQRLYFLDHREIHYLFRCVDAVKDVTITKKNNIIVAPYIALLTIASKGCKLTETMIEAFFPELYNEHSKKFKFNSQVSIIQEKLGYQFGNYHVYDFEPYYSTVALAIRDEHSSGIFNIRQESYLVSSLSEITYRFYLINLKSDLVQWSASTGAVINQMVNTVLITVYEKLQLVIENDSQFTCSLAVESKLPIKLLKDRNELFTKFINELKKTSSFKISKRDKDTLLKYFT
The following text describes a protein:
Function:
Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPFSDPFASATSKTVFFSDYVYVETTPNSPYLIRRIEELNKNQTGNVEAKVMCFYRRRDLPNPLVQLADKHQPALDEERTSPTQTSGGGGSATGNSGSNSSGTSNNNSSSTAIGGGAGGSGGAGGDAEKGEALTSKQRYQIKHRELFLSRQVESIPATQIRGKCSVTLLNETESLQSYLNKDDTFFYCLVFDPNQKTLLADKGEIRVGSRYQCDIPAKLKDTATDDRKLEELESLVWTPEHSLTDRKIDQFLVVSRSIGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMNILHKHEYSIEESMSSLVPSTGPVLCRDEIEDWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQIIEYYYMWKTTDRYVQQKRVKAVEAELKLKQVYIPQYNNNGKGNGTSTKAGGGIYNGTTNGSTDLSSNGKPCESCGTTKSSQWNSVSSGHSTSRLCLSCWEYWRRYGSMKSATKGDAGEGDAKKKSSSAASTPTATLAGLATTPTAVVDLNDDEKISDLTNRQLHRCSIVNCGKEFKLKTHLARHYAQAHGIAISSGSPRPIMKTRTAFYLHTNPMTRVARAICRSIVKPKKAARQSAYAINAMLVKQEFTNRISGKSQAEIKKLLLLKPKDRGSVTTIANRLGAPGSGPHEWLVLTPKDKMPLPAVVSFPKPPKAPDGSLVYDRVPNKSPDVVAVPADKELTIIPTQATSTIRKRAHEDQQLNGTEVTIVPSGPPAKRPNKDPMPSHCPSPEQFAAMMAASGQPLSRHHLNGKQKIAQMARGGNGRKQVISWMDAPDDVYFRANDTHKPFYRKTRKILSAVDLRRAARKPWRTLPIKPAAPEPSSRPIESQIVILD
The following text describes a protein:
Function:
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.
Subcellular Localization:
Cytoplasm. Membrane. Cell projection, growth cone. Note=Associated with membranes. Localizes to axonal growth cones.
Domain:
The DH domain and the PH domain are both required to mediate interaction with EPHA4.
Sequence:
METKNSEDQGKPQRKSVSSLWKSKHGPAEMRPELPPETAKETQNEEPRCLIPIQRNSLFNRAMRHKHKARSMSERRANDQAGDLPETRKSVNEPLAFNLPQGRLPPWRTPAQRGPGAQEASESSSTPGNGTTPEECPALTDSPTTLTEALQMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIQGNSDGSQAGEDNAEEEEEEEEEPASPPERRALPQICLLSNPHSRFNLWQDLPEIQSSGVLDILQPEETKLQEAMFELVTSEASYYKSLNLLVSHFMENERLKKILHPSEAHILFSNVLDVMAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKTAFRELIAQLELDPKCKGLPLSSFLILPFQRITRLKLLVQNILKRVEEGSEREGTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILEKTEDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRVHKMEDPQRSQNKDRRKLGSRNRQ
The following text describes a protein:
Function:
Mediates an immune response in larvae. DIF binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of the immunity gene CECA1. Involved in the melanization immune response to bacterial challenge, possibly by acting in a Toll signaling pathway that down-regulates Spn27A in response to infection. Part of a signaling pathway involving NF-kappa-B (rel) and Toll-related receptors, that functions in the apoptosis of unfit cells during cell competition. May be part of a NF-kappa-B and Tollo signaling cascade that regulates development of the peripheral nervous system.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Accumulates in the nucleus upon bacterial infection or injury.
Sequence:
MFEEAFGDIQEIINASMELNGGATGGGSVAGAVGGGGAAHHILSQSTSLPVMPSHIPLHLQNQNMNQNLPEPSARSGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIEVCNYDGPVIIVVSCVTSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPEERRLVLQKVGIQCAKKLEMRDSLVERERRNIDPFNAKFDHKDQIDKINRYELRLCYQAFITVGNSKVPLDPIVSSPIYGKSSELTITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFKTPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYPNPELLTKHNRRVAQKTVESLKRSLMSTNLHPSKQVKTSSQYTIFSKPQIATTTPQTQVSPGMPLMFPGGSPNFVQDIKMENGFMDVDSQSSQCPSVERNFASPRSNCSTVDSIPPMQMGQNQTHLYLPDATNFTFNGNFASPSSNCSTVDSIPPFQIGQRNNHMYLPENSNFPVNGCSPTHFSGGSMTPINNNNNVLINNNNNDFLSQKMSAISIPPQGNFGIKQVYQQTQQFLPQLQPESIPYLAQSHPEQSQYQQQQQPQEQQPPADEPTQSFSDLISSSIGMAPIDTSELIQDIEAELNSLGIQPFK
The following text describes a protein:
Function:
May play a role in cAMP-mediated gene transcription.
Sequence:
MELSAAAGRRRQAPWREFTGRHRTERSQERGSTPRKERSMGSRQPRKREREPRDCTPTCTNAASVSRSGARRAPGCAGRCITMKNCARAWRELSERACCFQAVPPSNMKQSWLIFLDTTLCSAWLLASSCPRLYAPLISFHCMCFNTVLLFPRLFGPTLSAKIQFNTDLSLRAIAWKCTKDTTTYC
The following text describes a protein:
Function:
May be involved in swimming motility.
Sequence:
MSEQRVTFNGDTRVLYRQAVRTPLPNEDAERLFHENMMNIADAQERKADMLADPDISLLEAYETQLEGIAKSYKRRCRHIAGDDYEEIAMAYNRGARDDRVGALTAYYFEGLWRMQQRITVTDMLFFPIILRYPDCFTVNIRFASGHTTTESVLYESPEHSTEELDDEYAERYYNESLYSQKEAAEYIRDTAEIIREEFPSPDESTFEERQYGGITSAGGRKGPVFSSMLKRVEPDPNRFSEPVDQPTLVEEGKEARRTERELLPEGAIVL
The following text describes a protein:
Function:
Plays a role in vesicular protein sorting.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MYDNPGNATDQEKFLDQSIRVVKAESFEMKRCLDKGKTMDALKHALQMLNEMRTSELSPKFYYRLYMDTMHELQCLEVNLIQEFAQEPSKLSNLYECVQYASAIIPRLYLLVTIGGVFIKCGLGSRKEILKDLVEMCRGVQHPLRGLFLRNYLMQCTRSVLPDFPETEEMLLSHNSTLPKGTPQLKPRDGTVEDTIDFVLINFGEMNKLWVRMQHQGPSKEKEKREKDRLELRILVGTNLVRLAQLEALTEEMYVRDVLPSILEQIVSCRDTISQEYLMECVIQVFADDFHLATLNEFLNACGQLQQEVNIKILLIALVDRLALYTNSSIEGQPAPTKMQLFEIFSEQATNLIKNRPDMPMDDIVALHVSLVSLAVKCYPDRLDYANMTFLGLRQVIEEKGITDIEAFGKVGRELTKLLNIPIDEYKNVLRLSELPEYIKVMNYFDYRGQCNIAAYMVQNMLEQETILRHQEDVDAAFSLISALLKDQEKQPESSHETEEFADEQNLVARLLHLIRADDVDSQFLLLNSARKVLGEGGRHRLRYTLPPIIFELYRLVLQFADMKDEDEKWDVKIRKMFVCAMGTIGALVSTAELAELPMKLYLNVSILVIIQFVDLKIFQGAITADRVLFEDNHTVVYEFVSKALSILEDDVVDSRDRVRCLQLTVGTLLKTTHLPEENWQPLANQTVLAAAKMFKKPDQVRSLVTVASLYWHGETLETNGDKMRNGKKVVDILRKSAKIARECLEPLVQQQLFIQLLSAYIYYYEDKCAEVIETLQWIIYCIFCFQINVDHIEELISRTQDNAVQLDVSAEADNLEKQLGETIHRLQLAKIDVAASQVASPRTEPDLPQPPSENEGL
The following text describes a protein:
Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
Subcellular Localization:
Chromosome, centromere. Chromosome, centromere, kinetochore. Nucleus. Note=Present at the centromeric regions, especially in the kinetochore domain, throughout the cell cycle.
Domain:
The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo.
Sequence:
MADVSRSSSLYTEEDPLQAYSGLSLFPRTLKSLSNPLPPSYQSEDLQQTHTLLQSMPFEIQSEHQEQAKAILEDVDVDVQLNPIPNKRERRPGLDRKRKSFSLHLTTSQPPPVAPSFDPSKYPRSEDFFAAYDKFELANREWQKQTGSSVIDIQENPPSRRPRRPGIPGRKRRPFKESFTDSYFTDVINLEASEKEIPIASEQSLESATAAHVTTVDREVDDSTVDTDKDLNNVLKDLLACSREELEGDGAIKLLEERLQIKSFNIEKFSIPEFQDVRKMNLKASGSNPPNRKSLSDIQNILKGTNRVAVRKNSHSPSPQTIKHFSSPNPPVDQFSFPDIHNLLPGDQQPSEVNVQPIAKDIPNTSPTNVGTVDVASPFNDSVVKRSGEDDSHIHSGIHRSHLSRDGNPDICVMDSISNRSSAMLQKNVDMRTKGKEVDVPMSESGANRNTGDRENDAEINEETDNLERLAECASKEVTRPFTVEEDSIPYQQGASSKSPNRAPEQYNTMGGSLEHAEHNQGLHEEENVNTGSASGLQVENAPEVHKYSHKQTNKRRKRGSSDSNVKKRSKTVHGETGGDKQMKTLPHESRAKKQTKGKSNEREEKKPKKTLTHEGKLFSCRKSLAAAGTKIEGGVRRSTRIKSRPLEYWRGERFLYGRIHESLTTVIGIKYASPGEGKRDSRASKVKSFVSDEYKKLVDFAALH
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.
Subcellular Localization:
Cytoplasm. Membrane; Multi-pass membrane protein.
Sequence:
METARDTVQHDAVLPAGDDDTPTLSSHALEALKEFLAEQSRAVEEASSAAAEDDVALVSEDWRLSQFWYNRETAETVANEVLNLCRSIDSPAIACIACPTLYAYLKKIDPNAPAQILEYDKRFEQYGSEFTFYDYNLPEDLPSSMKHSYPIIVADPPYLNCLQSNSIHCLITGFSPLDGMSQECLEKVAKTISFLTRPGQAYLLLLTGEVQSGRASELLGLRPCAFRPDHSSKLGNEFRLFTNYDPGTRLGGWEQAGLQTRMGQWWEGIPILTSAIVVVCGIIYLVCLLVGYDSFAEVCFWPSAVISRFQVYRIFTSILFHGSLLHVLFNMLALVPLGSELERIMGSVRLLYIIVLLAISNALLHLLIALLVAHNPLHPYPYFMDECAIGFSGILFSMIVMETSLSGAQTRSVFGLFNVPAKWYALILLVVFQLVMTNVSLLGHLCGILSGFAYTYGLFNVLIPGTSFFSAIESSTWLSTCVRRPKFIMCTGGNGAGYLPTHSNQTVTSRSEVLSGNIWENLSSWMPQRESSLSAQPVTDDSRFPGRGRTLSSQTTTTNHDSTLQARLLDGSSSPERSSPTATIAGERSLAGRLSAVDTTTTATRPLGQQASIPSDEEVQKLVAMGFEKTQVEVALAAAEGDLNVAVEILMSQQAQESPRAHNRRDAGSEMSYASWAGIQNS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) utilizing UTP and therefore links the biosynthesis of TPP to pyrimidines metabolism. By producing thiamine pyrophosphate, a cofactor of the mitochondrial pyruvate dehydrogenase indirectly regulates pyruvate oxidation and lipogenesis. Although it can also catalyze thiamine phosphorylation using ATP and CTP in vitro, it does so with significantly lower efficiency and without physiological relevance evidence.
Sequence:
MFLRQKLIMEHILSPLECLLPTGNLKYCLLILNQPLDRSQFHHLWSKALLKACADGGSNRLYDITEGQRESFLPEYISGDFDSIRPEVKEYYKVKGCELVSTPDQNYTDFTKCLQVLQKKIVEKDLQVDMIVTLGGLAGRFDQIMASVETLFHATSITPVPIIIIQADSLICLLQQGKHKLHVDTGLEGNWCGLVPVGHPCKHVTTTGLKWNLTNDVLMFGTLVSTSNTYDGSGVVTVETDHPLIWTMGIKNEPRE
The following text describes a protein:
Function:
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. The histone H2AB1-H2BC1/TH2B dimer is required for loading of TNP1 onto chromatin.
Subcellular Localization:
Nucleus. Chromosome. Note=Loaded onto the nucleosomes of condensing spermatids. Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition protein TNP1.
Sequence:
MSTSRKLKTHGMRRGKNRAPHKGVKRGGSKRKYRKSVLKSRKRGDDASRNYRSHL
The following text describes a protein:
Function:
May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.
Subcellular Localization:
Cytoplasm.
Domain:
Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure.
Sequence:
MLGMIRNSLFGSVETWPWQVLSTGGKEDVSYEERACEGGKFATVEVTDKPVDEALREAMPKIMKYVGGTNDKGVGMGMTVPVSFALFPNEDGSLQKKLKVWFRIPNQFQGSPPAPSDESVKIEEREGITVYSTQFGGYAKEADYVAHATQLRTTLEGTPATYQGDVYYCAGYDPPMKPYGRRNEVWLVKA
The following text describes a protein:
Function:
Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. May also act as a receptor for 4-hydroxybutyrate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAAPPLGRLVLTHLLVALFGMGSWIAVNGIWVELPVVVKELPEGWSLPSYLSVLVALGNLGLLLVTLWRRLAPGKSERIPIQVVQGLSIVGTGLLAPLWSNMALVAGQLHSVAFLTLAFVLALSCCASNVTFLPFLSHLPPPFLRSFFLGQGLSALLPCVLALAQGVGRLECLHVPANGTTGPPIKVSPINFPERFSAGTFFWVLTALLGTSAAAFQGLLLLLPSPPPEATMGTGLRVETPGTEEEEEEEEASPLQEPPGQVASIVSSPDPKAHRLFSSRSACLLGLLAITNALTNGVLPAVQSFSCLPYGRLAYHLAVVLGSSANPLACFLAMAVLCRSLAGLYGLCLLGMFFGTYLMTLAVLSPCPPLVGTSAGVVLVVLSWVLCAGVFSYIKVATSSMLHSGGRPALLAAGVAIQVGSLLGAIAMFPPTSVYPVFRSGEDCVDQCGP
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTSLDEPSQDWPACTLSYRHFHLLWTLPVCGVLLVIARPFLTKLDRAKLILLPIIAFVWTTPWDNLIVRNRAWSYHRHCIWFTIGYVPIEEYFYFIIQSLISTLWCTLITRWTLPNLYLTPSTPARRPLAPFAVATCVVCFVLGLQASVPATHTYYFGMISWWSSMPLALLLWGSIDFVRNMGVGAGFIPFAISVLGPTLYLWSSDIYALRRGTWHINQATSLNIFPIPDLPIEEMLFFLVTNVILVSACFTFDRCVAICRLSAPDHQPPLSPSYLPLGSLATYTKLWAAFVRSDRSSLPTSCASASVEPQDLSASLQVLRAASKSFNAASLLLPWDLRTDLGCLYAFCRVADDLVDDHAQELQAKAKNLDVVRDIVDAVYADSIVDRKQHLSTPIGERLRILLASAALSDKIKQDTRAAATSIAPLTQYIPKRLWYEMLQGYSADLRFQHQDARQRTRLQSMDDLVEYSQCVAGVVGEMCIRVILGRCGSTVPLDLEVDRKIALRASKTIEQSINVKPLDLNRTADVHTLLYEARRMGVSLQLVNIARDVVPDSVELRRCYLPADMFDKEEDDGMYEALLKGRVALPRHASKLVHGAEEQGVVRPQDVRKYALRLLEISQRLYDESYPSLRQIPNRPARAGLKAACSVYAAIGKRIQAQTEDEISSGRRARMSNLDRILRAISAVYFDV
The following text describes a protein:
Function:
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MSKRKGISLEEKRQRMLSVFYDRKEFFQLKELEKIGSKEKGINAMVIKDVIQGLVDDGLVDTERIGTSNYFWAFPSKAVHTRKRKIDDLQKQLGESERKRKATDESISKAKVGREDSESREKILKELKEKKIQCEKLTVQIEHYKECDPEVLEAKRQETQVAKDAANRWTDNVFSIKSWCKRKFGFEESVLDKQFGIPEDFDYID
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MKPPVIAIWLFVFGCVGAIPASNMVVEKPETDDIFSSVSKMEALVSQENAIVNMLDSFLIDAKQRISIIQNYVTTYRQVMSGDLSSSKLVANPVDAYHLLKRLTIDWDVVERVLEAESNSSRNALNHVLVLRETSVFPNSEDLHGAAIALVRLQDTYQLNVTDLADGHYNGVDHSKGQVFQSRRDLSGRDCLFMAQHAFADGYYDTALQWAEAALGQFARKGDNYGSELETFRNEVKHFVEFASRVHDDVLERQGPRGVNWQTNSHPVDRQFRSGTSEKYDSLAEQQFTPKLYQHQSEDEENEHYERLCRGEKLRSANIEAGLRCRLVTRGHPALLLQPIKVEEQSLDPMIVVLHDLITERQTEILRQLGEPKLATSLHRGGEGKFVRSMIRTSKNAWLQEHENASLPAIRHRMELATGLIYGPETASEYFQIANYGIGGLYKTHTDNVIHPDVRPEDQDPWNLYVGDRIATLMVYLSDVEAGGATVFPRAGVTCWPRKGSAAFWWNLYKSGEPDLTTRHGACPVLHGSKWVSNKWIRQYDQMFVAKCGLHPLEKYDSLLM
The following text describes a protein:
Function:
VirB proteins are suggested to act at the bacterial surface and there play an important role in directing T-DNA transfer to plant cells.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNFTIPAPFTAIHTIFDLAFTTSLDTMLGTIQEAVSAPLVACVTLWIIVQGILVMRGEIDTRGGITRVITVTVVVALVVGQANYHDYVVSVFEETIPNFIQQFSGSGLPLQTIPAQLDTMFALTQAAFQRIASEIGPMNDQDILAFQGAQWVFYGTLWSAFGIYDAVGILTKVLLAIGPLILTGYIFDRTRDIAAKWIGQLITYGLLLLLLNLVATIVILTEATALTLMLGVITLAGTTAAKIIGLYELDMFFLTGDALIVALPAIAGNIGGSYWSGATQSANSLYRRFAQVDRR