lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKTPKRRKRDQATIACLASNWSMHIHLRHDRKLLSSSLARERLYAYDTLLSNSGSTLLLVAASMTTWKFAGNIISFVVYLAPVPTICKIYQNKSAEGYSSLSYNLSLFSCLIWVYYAHLKPNSVLLISINAIGCIILTCYITIYLVFATRKDRISTIQVFVALNLVTFIGILFLTLLLFSGTNRLTVLGWICVGFSISVYAAPMSTIRRVVRTRSVEFMPVNVLVCLTLSAAIWFGYGVFTKDAFISVIITST
The following text describes a protein:
Function:
Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling. Plays a role in the activation of NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to activate TAK1/MAP3K7 leading to activation of IKKs. Once ubiquitinated, interacts with the dissociated RELA and NFKB1 proteins and translocates to the nucleus where it induces NF-kappa-B-dependent gene expression. Plays a role in innate antiviral immune response by bridging the pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development; As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
Subcellular Localization:
Cytoplasm. Mitochondrion. Nucleus.
Sequence:
MSWAQAVLLARSLSRGWGGICSTALTGAPFSQYHSSQQCQILNPLMEARVRTHILMDTSQVPLQAAHGLHCSTAMHTFDSSLVPHPPKPPRRPIKALALHEELFRKAPDGTREKASFVQAIQDFAQYNVHKRGHVDFIYLALRKMREYGVERDLAVYNLLLDIFPKEVFRPRSIFQTIFYHYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKYVRMKLWFTRFRNINPFPLPRDLPQDPVDLARLALRHMEPDLSARVTVYQMSLPEDSKDAVDPTEPHIVGIQSPDQQAALACHDPARPIFVEGPFSLWLRDKCVYYHILRADLLPPEERKVEEIPEEWSLYYPMQLDLAYERSGWDDYKFNINEVEEGPVFAICMAGAHDQATLAKWIQGLQETNPALARIPVVFRLAGSAGELLASSSGPEGSSPPPSEGQEEEDDNQQRQQQGQS
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing by facilitating excision of introns featuring relatively long (>21 nucleotides) spacing between the branchpoint and 3'-splice site (ss). Recruits cactin to the spliceosome which may enable folding of RNA between the branchpoint and 3'-ss, to guide the splice site towards the spliceosome's catalytic center. Required for proper chromatin organization by assisting splicing of components involved in genomic stability and telomere organization.
Subcellular Localization:
Cytoplasm. Nucleus. Note=The unprocessed form localizes to the nucleus. Following cleavage in the nucleus, the C-terminal sde2 remains nuclear, whereas the N-terminal UBL appears to disperse throghout the cell.
Sequence:
MECKTVFLNGDFLKNSVNVNLNRLATVETLLRHVLGDSYETVLERAYLTHQSRIVHPDIQLCKLEGKSTSAHLNLTLCTRVLGGKGGFGSQLRAAGGRMSKKRNEQENQDSCRDLDGNRLGTIRQAKELSEYLAKKPAETRAKKEAKKQKLNKVLAADSSSSRFDDHEYLEDLEQSVSNVRDAFQNSLLYRRGSTSASSFSSGSNGATTDEPAEKEARNNNSSINSWSRRMQASESSNEAEGEDSESQTSKSLYEWDDPLYGL
The following text describes a protein:
Function:
Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLVISAALIVFISTFVQLFLSPFTKVEESFNLHAIHDFIHQPNLSAVAHAGDHLQFPGPLPRTFIGALLIGGVSRALLPILRFIGLVHSKFAEQIFVRALLAILNSSSLVYFGLCARFVFGDLVSISMLLLSASQFHLAFYASRTLPNMFAFPFVQIALGQYMITMKRGKTNSARKQGTLNACSFLTIAAVIFRLELVALLAPIVLLSLISKRVTFWQLVSRGFLVTFAGLEMTLPIDSYFWQKLTWPEGASLIFNVLEGKSAEWGVMPWHFYLTSSLPKLLGITYPLALLGFVLNRKVFLLGACTLVFVVAMSCLGHKETRFIIYIVPVWNLSTSICVHRITSPFRHSRWIKLGLMSLIGVVAALNMAFTTYLSMHNYPGGAAMMALHSLEDLRPIQELNIHLDNLVSQTGGSRFLQLNDLDGAQNYPLTTKGRLWRYDKLANITESSHQFDVILSEQPELHNFQALEHVTAFDGVRRRHFKAPLSDRLFDFVQSCWAKKACFSFHSMWDILSPIEIVFNHKQITIFLQTNPT
The following text describes a protein:
Function:
Signaling adapter of the reelin-mediated signaling pathway, which regulates the migration and differentiation of postmitotic neurons during brain development. Mediates intracellular transduction of Reelin signaling following reelin (RELN)-binding to its receptor: acts by docking proteins through its phosphotyrosine residues and PID domain.
Subcellular Localization:
Cytoplasm.
Domain:
The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.
Sequence:
MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPVSAVTQLELFGDMSTPPDITSPPTPATPGDAFLPAPSQTLPGSADVFGSMSFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQIAMGAQPPVAQVIPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTNDSARSSPQSDKPRQKMGKEMFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHVSDPTADDIFEEGFESPSKSEEQEAPDGSQASSTSDPFGEPSGEPSGDNISPQDGS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MPFGSCGLRGRVPGLAAPGLCVPAFPARAREHFRPVVKWVSLWVSLGGGWGAAETQALGWRLWSLGEQSLPRSTHRQCRKPPDEDDPAKVEHPGQMMAVASPPPEPEDLLIVKLEEDSWGSRSRPEESSHSSVPGPEVSRLCFRQFQYQDAAGPHEAFSQLWALCCRWLRPELRLKEQILELLVLEQFLSILPREVQTWVQARHPESGEEAVALVEDWHREAWAAGQQGLELCTEDTRSFEAVQEFQRFQLQPVAHCSERQPQKQRVEKTHPGLSKMPPESLKESAVFTPQAPSVPKMASAGDWEMAAKSQETLSPSRQAQEEPCQDPEGEDCGNSACLGVPASKPSVASQHEQGAETLGLSLLNFGTGSAADGSVDSEQDKAARGAAQADARAWVEPCQWGTEDMKVSGVHWGYEETKAFLAILSESPFSEKLQTCHQNRQVYRAIAERLRARGFLRTLEQCRYRVKNLLRNYRKAKNSRPPGTCPFYEELEALVRARTAIRRTTGGPGEAVALARLGDSDTEMDDQDEGSWESEEATQDCSGSGLAAEESIHGPRIAGGPALLQSRIAGMHWGFEETKVFLAILSESPFSEKLRTCHQNSQIYRAIAERLRALGFLRTLEQCRYRFKNLLRSYRKAKSSRPPGICPFYEEMDSLMRARTVIRAMETVGEAIGLPGPGQSGTEADDQEAWGEMEDAGAIRLLTPDSQTPGFELKPEDEYQISERDDLGDSPGALSRYTREAVCQPHGWREDHENGDEGEWRNTLPWDECSSEEDLEKLIDHQGLYLTEEPYRCDTHVKSFSRKVHCFAPQRIHAGEKPYKCLDTGKSFSDHANLSTHQRIHVGEKPYRCLECGKSFNDPSNLITHQRTHTGEKPYKYGVCWKSFTESSNRLKPQRIHLQGTPDQRNEPGEDFGQSPSFSAYWRDSTRERPKQPQNISMGADSPGACHPNSGEKLYPCPECGRCFSKNSALMSHQRIHTGEKPYECVECGRSFSKSSSLANHLRTHTGEKPHKCADCGKCFSERSKLITHHRVHTGEKPYKCPECGKFFRDRSNLITHQRIHTGEKPYKCRECGKCFNQSSSLNIHQRIHTGEKPYKCTECGKDFNNSSHFSAHRRTHTGGKAPPN
The following text describes a protein:
Function:
Required to generate and maintain the structure of the tubular endoplasmic reticulum network and the digestive (food) vacuole. Induces high curvature in membranes and causes membrane tubule formation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The N-terminus is important for protein stability; The C-terminus is dispensable for the formation of membrane tubules; The short lumenal loops between transmembrane domains 1 and 2 and between transmembrane domains 3 and 4 may impart a wedge-like configuration, thus deforming membranes.
Sequence:
MRMSKLYKNKEKENEKPSNEPPIKQDSLKRMSSKFLGNSLNSFDLSGKLEQVDEYLKKYPFIIEFGYKLGIKPSYIVVFGGSALFISLVLGWGAALICNLVGFAYPAYQSFKAVESQGHAETKLWLTYWVVFSLFFFIEYLIDIILFWIPFYYVIKLLFLLYLYMPQVRGAETVYNYIIRPILLKHEKTIDDTVHKISQTATNHLNQFTGNIAEKLVQEGVRRRNV
The following text describes a protein:
Function:
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
Subcellular Localization:
Nucleus.
Sequence:
MAEQQTTELTNIDLEAGSEWRFELEADENIALRTLSSDPVFINSQELTPSAWYPIYRHTKSALYAPTSARIQVTNLPASHYTSTSTVQPQLLNLHLAMERQRILSKRGMEQRGPRVMIMGPQSSGKTTVMKNLVNLALGTGMGWTPGAIGLDPSSPPNLIPGSLSISTPSHPIPTHHLAHPLGSPPASTAANTISGDVETASWWLGALEPTNKNAEVWRVLVEHMAEAWGMRCEKDKIANISGLFLDTPAAFTVPTLGTKKDDPKARYTLVSHAIQAFDIDTIIVIGHEKLHIDLSRLPLVQSRQLNVIRIPKSGGAVDLDDHDRETAHIFQVRTYFYGEPPLPPQISSLVGKMVSLDFELSPYSFQIPWSRLVVLRVGEENSAPSSALPLGSSKILSPLRLTRVDPSGPGHVVRLLNRVLALVDVKPEDRIVPAKESEVKEEVKEEKNEKDGEIKQDGEGEKKGEGKGEGEGEGEGKDGEEEGEAEGEDDEEEVPFREEIGTREVMGFIVITAIDTFARKYTVLSPTPGRLPTTVAIAGAIEWVDSA
The following text describes a protein:
Function:
Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity. Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons. Also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (By similarity). The transport activity is specific for L-glutamine, L-histidine and L-asparagine. The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+), pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions. Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport. In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Note=The localization appears to be basolateral in the plasma membrane of hepatocytes surrounding the central vein. Localized at the cerebrospinal fluid (CSF)-facing membrane of the choroid plexus epithelial cells. In astrocytes, the localization at cell membrane is decreased by ammonia through the PKC signaling. Expressed in both luminal and abluminal plasma membranes of larger microvessels and blood brain barrier (BBB) capillaries (By similarity). Restricted to the basolateral membranes of S3 segment cells of the proximal tubules.
Sequence:
MEIPRQTEMVELVPNGKHLEGLLPVGMPTADTQRAEDAQHCGEGKGFLQQSSSKEPHFTDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYSIHLLLKSSGIVGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEKPTPVWYMDGNYLVILVSVIIILPLALMRQLGYLGYSSGFSLSCMVFFLIAVIYKKFQVPCPLAHNLVNATGNFSHMVVVEEKSQLQSEPDTAEAFCTPSYFTLNSQTAYTIPIMAFAFVCHPEVLPIYTELKDPSKRKMQHISNLSIAVMYVMYFLAALFGYLTFYDGVESELLHTYSKVDPFDVLILCVRVAVLIAVTLTVPIVLFPVRRAIQQMLFQNQEFSWLRHVLIATGLLTCINLLVIFAPNILGIFGIIGATSAPCLIFIFPAIFYFRIMPTEKEPVRSTPKILALCFAAVGFLLMTMSLSFIITDWVSGTSQHGGNH
The following text describes a protein:
Function:
Involved in retrograde signaling from post-synaptic cells to pre-synaptic neurons, probably by regulating vesicle exocytosis in post-synaptic cells. Acts in muscles, to regulate the localization of synaptic vesicle fusion protein unc-13 likely during vesicle exocytosis and thus regulate retrograde signaling at the neuromuscular junction (NMJ). Regulates anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). Probably by regulating DMP, plays a homeostatic role in the uptake of triglycerides. Regulates locomotion.
Sequence:
MREEALESICAALSISFTEDPDHLESIIDRFSEIFKVKDHLNQLRKKCEKFQTFTLEIRPVGSSNCTENVYAYIIESETCRQLELKPTGTTKLEIGSDKNVSLKFGLSQKKDSTTSKKGLSRSASLLKKLKFSDKKNLDELKISIFPLDIAVRKNINLGSGKSTLLEMKLIRNDHRNMIQCLEFDDFLEMTRSFHEWQAQISESELYDGSLGDPTFSMFYSIAFFFEIPSFVLKLTEMTCFLVWDDEMKKLDERALADVSLKMTACESEVDLQHPLLSPALSYLNDCTCNTIRCILVPFSTEPFFPPVSPSRLKSINVALKLIADICVLDVWDEFENLANPSNFLSSELKKLLESSAERYGESLKKQEFNELCRTILNLWMSLSNESQPYYIFFHQFDINYIGAAMLKLDKYLAESIQISLKCQLDLLNLRIPTELENFTKTTMRLFVTLRNLLNMVEAFHLPECQLFHFEEWFTDISVFWTYSWREVTLQMVERTITLDEDGDSVKYGARRPLPAGLYSFLCIQKGISDDLARLEFTFPHHLVVCAASVVNIMCQNINAYARKLFSEAMRNHEEKASRLVRATNGIEQAMCFVEEGYRRFAQFQRLEEYVDVDDLSAVRSTSIRLLKSTRDTCEIQVSTLLSHFVNLKTDIVLKIAKNLCADGKESNSGLKSYMRELASSERIESILECCYGLVDDVRCLLLPNCFKLSTQHFATSLEQQIRKNIRQKQPAEYYSNIYVGFLNILIFKRLKQMYLKFQIALKYIYEFLEIEDRKDIELLSNLHLNSFSTKDLILSYYDSLCEKIDRTRFGNAPHVDVHISYVKMVDEDTISIQIKLIKMSPIEWIDVISDRVDYFVRLELFPKILFPSNKFESPTTNPMPQSTRPQWKQLFEIRVPLECFFLRGACLAISVFDHERFIDRLVGRGFISLHSVPQASEEKPTQRLQVPLLPNDFSDQNNVFYQLLKTRACRDSIAKEFIETRTRRHQRIRALQHYIRINRNRVGHMLLG
The following text describes a protein:
Function:
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone.
Subcellular Localization:
Cell membrane, sarcolemma; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Membrane, caveola. Cell membrane, sarcolemma, T-tubule. Note=Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks.
Domain:
The cytoplasmic domain is sufficient to regulate sodium/potassium-transporting ATPase activity.
Sequence:
MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR
The following text describes a protein:
Function:
Hydrolyzes acetyl esters in homogalacturonan regions of pectin. In type I primary cell wall, galacturonic acid residues of pectin can be acetylated at the O-2 and O-3 positions. Decreasing the degree of acetylation of pectin gels in vitro alters their physical properties.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MVLKIIETESSPSKGTSETARLHLPELSLQVLSQQGAEYDEYGKEEYFKRDDADANSPSIEELVKVFNIDHYPMRIQCDGAADLMGDFVVKSAMGKYFNVFRKILREQKLDAYSGTGHQQNKNGIVWSNNHYKKIILEGGLAVVDGAIGGGSGVVVNALLTVFKANHYEYDHTGYTNFASPSKCFACKYQDCRAKHDVVINAINALTASVKELTSKRGLISSKRILFSSVPLEIRAKRRRRVIFRALSSIQKSEITTPLSVCCTEQRTMSKGEQHEMKKDDNIYVGFGSMSRSILYNSCSRGKGRFLCQYHILESATAQGAEFNNWNRVRVKYCDGSSFTGDVEQVDRENKLYFRGARIFKAIMEDLWSKGMKNAENGSTKNLPSPCTSVMKPSLCFFPQNVIPYIQTPLFIINSIYDYWQINNTLVPVHLDPQHAWKDCTEQINNCTFSQRIVIQAFGMEFLKTFEKLPPSFTRGYYLTSCFSHGDLYKSAYWFSASSPRLLNKEDEVVMRLDSQDVCKKDSFKYLGSTIQGNSEIDEDASKYIGASWIKRRLASGVLCDKKVPLNLKGKFYRVAVRLTMLYGVEY
The following text describes a protein:
Function:
Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MGPLSPARTMRLWRPRSLGVALGVFMTIGFGLQFLGGSFQRRLPGLQLRQSWVPSLGSTVKSCLPRQRLVFLKTHKSGSSSVLNLLHRYGDQQGLRFALPAHYQFGYPKLFQASKVKGYHPQSADTQKPFHILCHHMRFNLKEVLQVMPSDSFFFSIVRDPAALARSAFSYYKSVSSAFRKAPSLAAFLSNPQAFYRPGARGNHYARNLLWFDFGLPSPPETKTMKVSPQLPRDPKSLQLHIVPSGASPGTLFRPVTTAADSYKQPASLVSSDFRPSSFIQWGLAWLDSVFDLVMVAEYFDESLVLLADALCWSLDDVVGFMHNAQAGKKQSLIRTANKTVVTGEDQQLTKQARAWNNLDWALYIHFNRSLWARIEQYGRSRLQRAVAELRARREALAKRCLVGGEALDPKYIADAKLRPLQFGSAKVLGYVLQSGLNQKDKEECERLATPELQYKDKLDAKQFPPTVSSPLKTSRLLSP
The following text describes a protein:
Function:
Required for correct meiotic chromosome segregation and recombination. Accessory protein required for Rec12 activity, which is involved in formation of the double-strand breaks (DSBs) that initiate meiotic recombination.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MYTYDSSGETLKIAIAWKIILKKPKGKNIKDYIEALRKGIEDQEHCEKYASTLLEPRPKTKKDVVLKNSNVTECVALKAKPFSKKIEDMDIFLLTNVHENLQEKRQTSGSLAHLDIEYTFNGLFRFLKCTADIKLKQTKVYEGADFLRIKTLFEEIFMFLKRDCKSPLVLTRLVELGDYVLDLIIITQSIMQNNANNGTGVISRAKFLEFYVFLEQLIFNKLSFASVEQLEKLLDQIVKRMKICFTYCKNDNPSIRLLYSECFFSYAEIYFPCLHSFDAQLSSAASKCVQILRDIITNEELQTDKQELSKSAYSAPSILLIGLKDMLFPEDIS
The following text describes a protein:
Function:
Acts as a central player within a network of stress response pathways promoting cellular adaptability. Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MEDKKEEGESEIQEHGPEHWFSKWERQCLAEAEQEDQPEEEAEQSQQKLWHLFQNSATAVAQLYKDRVCQQQGLSLWVPFQNAATAVTNLYKESVDAHQRSFDLGIQIGYQRRNKDVLAWVKKRRRTIRREDLISFLCGKVPPPRNSRAPPRLTVVSPNRATPTETGSSVETDLQPFREAIALHGLSGAMASISVRSSTPGSPTHVSGSSNTGRRRNGLHDVDLNTFISEEMALHLDNGGTRKRSSAQCGDVITDSPTHKRNRMI
The following text describes a protein:
Function:
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).
Subcellular Localization:
Nucleus.
Sequence:
MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPGKHLLKQLGQLCTSPLNVGRSRSWELRKGRLWGPD
The following text describes a protein:
Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.
Sequence:
MAAMGESSPSIVEYFGGDGGYRCGYCKNDTGNLSQGMWAHSLTVQDYQDLIDRGWRRSGKYVYKPTMNQTCCPQYTIRCRALHFQPSKSHKKVLKKMLKFLMKGELSKIDSEVEPMDSHTKDADDCSFLLKNEPDTSQSELEPLSIDYTEKVESEEETKGEINAKKVETQPVESCKETIHDNSSKPLQLAKKVGHATPKPGKGADLSKPPCRKAKDIRREQKLQKNLQNPTVQEGTQNLHGQSSKTKTNQPKSIEDFIFATLPSEALHHLEVRLVQSSPPSSQFKATFQESYQVYKRYQMVIHKDPPDKPTTSQVRLVPVSFEDPQFKSSFTQSAALFAKYQISIHKDAPYECNENQFTRFLCDSPLEAENLPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPKSVSSVYLYYDPDYSSLSLGVYSALREIAFTRQLHEKAPELSYYYMGFYIHSCPKMRYKGQYRPSDLLCPETYVWVPTEQCLPSLEHSKYCRFNQDLTAGDEGNLKELDQVWILHKRTAMRYSVYKRRRKGLNDEETIRQYATLVGQACSERMLLFRS
The following text describes a protein:
Function:
Removes the pyruvyl group from chorismate to provide 4-hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p-hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MTECFLSDQEIRKLNRDLRILIAANGTLTRVLNIVADDEVIVQIVKQRIHDVSPKLSEFEQLGQVGVGRVLQRYIILKGRNSEHLFVAAESLIAIDRLPAAIITRLTQTNDPLGEVMAASHIETFKEEAKVWVGDLPGWLALHGYQNSRKRAVARRYRVISGGQPIMVVTEHFLRSVFRDAPHEEPDRWQFSNAITLAR
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEQQQQQRVVFVRKVGAGNLAEELKTIRYHLAMYPCIAIDTDHPGNICSFPSPEVREEDLPATARYDVARTNIGALHVLQLGITLFDSRGNLPVLPTSPSGRGASSLPTVWQVSFSDFDLRRDLCSAPSVEYLRSQGLDFDELRARGVSARAFGAALAEYGIICGPKYRTELKWVAFGGIYDYGFLLKMLTGGKPLPDTREKFMAALAERVGVRVYDAKYVAACAGVSGGLMKVAKVLAAGAGVPRTIVAPQSERRQAGEKSLLACQVFVAIEQRFFGPSHIEVPGARIDGVHDRRTVLVHEL
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MKRVWPRIPTISNVCRARSIYSAAQENAYRSSVKLIQEYSEKVHKKLQAKLLENPSETSPEIERLQVLSQINLPEVRSKFHKKEIDYTNPVFLYMLKQQWEDYQKLLLLQRLEQMKVIKDSGIGSFSPSVDVQLGFNPENNDSITPGTILPSTVTVKTPWLSVLPFNCKKNHYSVITLDLDVPNYETNRFETHCNWLLTNIPIEASKRVPIDTSKAFFQYRPPIVHRGEDKHRILTLVLRQKSSSISIPSNALVRERFDLSEFCSIYDLEPVGAHLWRSGWDSDAVALLSKHPSVHEYRDIRVERIPA
The following text describes a protein:
Function:
Possesses calcium-dependent ppGpp (guanosine 3'-diphosphate 5'-diphosphate) synthetase activity in vitro and is able to functionally complement E.coli relA mutants. May be involved in a rapid plant ppGpp-mediated response to pathogens and other stresses.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MATAAAAVPAGGHQHRLGLRPRPSPSPLRLHRLRLPASAASTSSSAPSTSSSSSWTPAEGGGRLVAELVGTFNELTGRMGEGLATTSSSRLLFRALKLALPALRGGGDGDGGRALSRALAVAATLADLQMDAEVISAGILRKALDAGAINMSDVKEQIGTGIADLLHESLRLKLAPSKVDILNDESVSALRKFFLSYYDIRAVILELALKLDTMRHLEYLPKHLQRIKSLEVMKIYAPLAHAVGAGDLSLELEDLSFRYLFPHSYDHVDQWLRNREAECKFLIKAYKEQLIQALKSDDELNKIVQDISVEGRYKSRFSTMKKLVKDGRKPEEVNDILGLRVILDPRCDVGSCDWGPRACYRTHEIIRTLWKEVPGRTKDYVTRPKRNGYQSLHVAIDVSEPGKTRPLMEIQIRTKEMHIIAIGGEASHSLYKGGLTDPGEAKRLKAIMLAAAELAALRLRDLPASDSQGGECKNQAFCLLDKNGDGRISIEELTEVMEDLGAGDKDAMELMHLLDANSDGSLSFDEFESFQRQVELMRSLEDRDDHYTKILKDKLQMIDSAGLIHFYRKELGDKLLVI
The following text describes a protein:
Function:
Seems to be involved in cell wall organization and biogenesis.
Miscellaneous:
MISCELLANEOUS: Present with 1080 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MGNTDSKSSSILLNHCIALVRPEDADASSPSRTSSPSPSLSVDADPLSLNLSIFKLDSGPDVEALFSDKPNVPLDTVFNDFYLDFISVDVQDFSINSSFKKILHIISSLNPPNFNNLIVFLSLYIILSANSLPASRTGLHSSRLINAIKTLSILIPIYFDRVKSSTQDHYDVFWATQHEIEGLPLQNIPLGERLLLAILKLAFQDNFTTAVTAHPSELWEIGILTNSNKYRSLLNMHHQWHLFANRLLLLRLLAALFSSDLYTSGGKQDINMFLVYWCTQMPKDKSIQFTSSLLNCTMRFILNNNKDFQSLKANFFSSDATASNWQTLYFQFVQSCLHVLNLSMSYKAQDNVITIFLTQLQREYDLKLILSSFIKIFKYPIDLAIEQESNIFNFTNNKHIDASRRRAVSTSSHDNSSSSHASLPSSSSAAYHTKPQTKPQLPEIHPLLIPMTILMTNLIDCNKCFQNYFADKFASRFIIFSIYYLKYYDYSSLSSSSSTTRSNSSTTSNGTSNDTSNERSIVELNENSVSQILLPLLNHLLLILTSKKLVLFKMLQTFNLNYYTNNLPNFYKLSNINGDINNLTFRDFTVIQLSNLILDNIKFNLQPNPIFYELIYNLLPINDEILTSSHKNDDSHDDLILLSAKKKSASPSAATSSHTSSSKLSYNAAMSLLYVLSKSSNKVYLTTYATPVFKTKDIPYMISPGFKMDLLALLLRSITIFFTLYFDDAENLLFAMVRHQSITHQINDSINSISKALDMNPNLNSHIMTLKQMGFNRKVQWKDFYQFEEITDLPQVNLYSSANQQHQNQQQGQNDNRGQNQNEDPGQENESPTPYLLFNPASLENETPGTVKHFSSTNHDKNYQVIAFIDFKSDSNLNLQHQLEYWPHRPQWPTPLTFTHKCKNPKYENFNEVWSGTVYLQILLRVIKQILSKVPEIPRIKSVQYFETLSKLSALRSDILTTIHPRLPLDVRRLTTFQPLSMHTNDKLLMWFHIATWANIFTQTSFKYEETFSHELRQFESLLDISIDECEGNTISKPTTDRLGYIRRSRGQSSVSLERTISAGSGVSTPTMALNRTKSNGSGNLMNYFFQNTAQNHFQHLRSSSSSSSITLEKTTSNSSSIRTRPNSHHVAPETNNNNSTNGNSNNSSNGGFSFFKWKWGGNNSNGGSDDTKASQRDPNVSTSIITDNLNSYMFEEEISPGVVNNIIENNIWVGTDIRLFKIANFRKESFSFLEMTSSFFKKFKFINSDNDNYNNNEFDDNTQLRYTSRGLYR
The following text describes a protein:
Function:
Cross-linked envelope protein of keratinocytes.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSYQQKQTFTPPPQLQQQQVKQPSQPPPQEIFVPTTKEPCHSKVPQPGNTKIPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGYTKVPEPGSIKVPDQGFIKFPEPGAIKVPEQGYTKVPVPGYTKLPEPCPSTVTPGPAQQKTKQK
The following text describes a protein:
Function:
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). Required, indirectly, for activation of ribonucleotide reductase through the degradation of the protein spd1, thereby supplying deoxyribonucleotides for DNA replication and repair.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSLNLLVNQEELKRYLDEYGVWSKIFRALFVARNSKPLRSFCVHYAIKELKEKTYNLELYQSLFEEFQDCFENEQLDVEWVESVTFHRKQNLEQLRRELKAYKNNLIRESIRAAQLDLASFFADVGQFDSALRSYAKVREYCTNAGQIAHLSLELMRISIWIGNYSHVLAFGSRAKSTVSAAMELTSPIYAYCGLANFCLGDYEEALAHFLKVETDTSDGIITKTDISVYISLCALACWDHKRLIQELERNEEFNALSDLDPSLRRCLQAKCNRKYSLLLDTLQQNAQDYSLDMYLAPQLTNLFSLIRERSLLDYLIPYSALPFSKIAVDFHIDENFIEKNLLEIIEAKKLNGKVDSLQKRVYIEPSSEPENFEDIKNIAQTSLLYSKALYLQTLAAMNTENTDDEAPVIAQTNITAEDSQN
The following text describes a protein:
Function:
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAADMFTVPHTVGRVLCCICGVTLPRKASNICVTLLRCQVDITDGLQKLATVLYFRECGQFLQPPRTWVKAELESKEPFKEVINGAILEQAYVVDQRVEDHMCEKCSRVAANPDQWIAFVQVKQKVKHKRTFFFQEQLIIKHGSAAAAVNIKQIHDGMDFHFEYDKHLVPQDSKSNTYNYRFTMSVEICPACKDGLICFPEKVAASLGNIDPLVLCTQVSNSLLLLDPQTLRTAYTDANQYWRTGFSLGFRPLLHARQLVEYTILDIEIDPSASTRAGKYVLADVQETLPWGCNVYSANTNDPELEKYRNLSLPNVVLVKKRYEEKRTRRRGKPRPWKLKALDMEIDPSAIRQDRENVSNVYERILEEIKEDLEMHAMIALYGDVNYRPQSETAAMIDGDGDEPPSVQLEELLADLRIDCNNDESETTEDEQMDDA