lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The subtype gamma methyltransferase (M) subunit of a type I restriction enzyme. The M and S subunits together form a methyltransferase (MTase) that methylates A-2 on the top and A-3 on the bottom strand of the sequence 5'-AACN(6)GTGC-3'. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. After locating a non-methylated recognition site, the enzyme complex serves as a molecular motor that translocates DNA in an ATP-dependent manner until a collision occurs that triggers cleavage.
Miscellaneous:
MISCELLANEOUS: Type I restriction and modification enzymes are complex, multifunctional systems which require ATP, S-adenosyl methionine and Mg(2+) as cofactors and, in addition to their endonucleolytic and methylase activities, are potent DNA-dependent ATPases.
Sequence:
MNNNDLVAKLWKLCDNLRDGGVSYQNYVNELASLLFLKMCKETGQEAEYLPEGYRWDDLKSRIGQEQLQFYRKMLVHLGEDDKKLVQAVFHNVSTTITEPKQITALVSNMDSLDWYNGAHGKSRDDFGDMYEGLLQKNANETKSGAGQYFTPRPLIKTIIHLLKPQPREVVQDPAAGTAGFLIEADRYVKSQTNDLDDLDGDTQDFQIHRAFIGLELVPGTRRLALMNCLLHDIEGNLDHGGAIRLGNTLGSDGENLPKAHIVATNPPFGSAAGTNITRTFVHPTSNKQLCFMQHIIETLHPGGRAAVVVPDNVLFEGGKGTDIRRDLMDKCHLHTILRLPTGIFYAQGVKTNVLFFTKGTVANPNQDKNCTDDVWVYDLRTNMPSFGKRTPFTDEHLQPFERVYGEDPHGLSPRTEGEWSFNAEETEVADSEENKNTDQHLATSRWRKFSREWIRTAKSDSLDISWLKDKDSIDADSLPEPDVLAAEAMGELVQALSELDALMRELGASDEADLQRQLLEEAFGGVKE
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MAQRPHGLKLSRGQRRAEPHGGVGGPPLTVRDQEPILIVDEDEDGGDDAGSAGGLGGSTAMARARAKRPAAMQAARRGPGVSEPPPQRSRSAPSSQSAHGSLPRPTPVQAATSLTHIPTPSSGTAATITTTPLRRRRASVAEMLRSKERPGRLPACPSCGVHMHLTALHRHLDACLSKHATPPRPATPPPSATPINWAPQTILYSPDTCARLTRQRPPLAACLTPQRLDFATEDREPATTPDSSASQEIRQPPASPSELAERASACFLCGEPTHFARVCPQGPYYVYYFCREVSAVLQHSYFCTLFTPAERAQLEAICALPRPELCLLVRLYNRSPRWFAATTLRYPEIAEDVQPILARLVQAGAMIDAQHLDDPQAALELLNAQQLIELRRRLHLDKVDLGTGRRDVMTNLLRAAAAQSTLAGPAGPALVLRRAKRLLGSCYALEPRVRQLLELCTILFHHKTHWSDAGPYVQMQADRGVCRYPAYIITTTKPAFASRSQLEDYGQALALERQLERTWERFDSAAVLQHLAPTVAALERCLATRLLSDEAAATVHTRFEPGCMHCIAQPASGIFSHLFMSGCLPALHGNSASVAAGKAASPAAMAIGPSRTVLSLLRRATRLCKHKEHESLHKHLSKLPDIALNLGETLVIHGQAMSDREVGRRMNFLYNHQACSVEDLVLLHAAERGWKGSHCEGRYLAMLFTLLLWDLLFSAQPDVFVTPYQIAPLDLHSDGFYARRATALRLRLSQLSYADLGHELTKAWNEHHGTTAVGVHWDLMSLSELVESARCIGNEVVCRMLDLLAQDYRHRTGGLPDLLLWRAEYDADGHLTSGQARFVEVKSPNDRLSDKQQIWLHVLQEVGAAAGVCHVKVTGAKAEQLAPPSSPSSS
The following text describes a protein:
Function:
Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.
Subcellular Localization:
Cytoplasm.
Sequence:
MLPYLAYRYVKNKREKNQREMDNDLDSMVRSIVPDKPVVSISGVAAKLEETSREYIPGVYRLLRNPLEFSSNGGHQKTRMHHDGNSEMVHSRSPEEKRDRGARVAFSMDVNDLSSFRNEEPKRGSGGFPSIRLICRDGSSQVPLFFRNCSTGEFIDRLQGYITLRRSNREANLVIVVDQKSEALAKSVSMLDENGDILSRFMQNPYMTAMTGFSKITSFVQDQVIPSVLNDTDAVTQEEKIRLMRELRLAEEQMRVHSDAAGEFEVVTQLDLPPRPEIYRELPVSKELWNSFKLPNGSYDPLKLHHLKMNVFRGGLNAELRKEAWKCLLGYRQWHETDAEFEKKRAELAKQYQNMKNQWMAITEDQEKRFSKFVKRKSLVEKDVARTDRTVPFFQGEDNVNLVHLHNVLMTYVMYNFDLGYVQGMSDFASPLLFVMKDEVDTFWCFVGLMEMTHKNFEKDQAFIKLQMNQLRDMVMIVNPKLANYLESEKSDDMYFCFRWVLVWFKREFSFLDTCKLWEVLWSGQPCPRFLLLICVAILDSQTNIIIDNQFGLTEILKHINDLSMHLKVDEILTAAEAIFHQLSASQNKLPTHICQYLNIGESAVSSNSSSPAKGDSKDL
The following text describes a protein:
Function:
FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
Subcellular Localization:
Bacterial flagellum basal body. Cell inner membrane; Peripheral membrane protein.
Sequence:
MTMEDVEVDQRKQLPNYLLDAAGISIERMPMLNVIFDRMAASCTDSLQPMAGTPCYFSVNGITNDRVGDIIKDYEANAVAAVLYAEQWDSRIIIMLDRDFVFTMVEAMFGSDGAEPPLDVERSFSNIEIRLVQALFERFAKALQSAFAGTSNVTFRVERVETAMASLAIGRSGNMSICANIMLQALYRGGQMFLIIPHSALNPLRQKLAHVVVSDGRASDPRWREQMESEVHRTEVTLSAVLDEKMVTLGDVVKFQVGQVLELEATPRTLARLESNNQVLFWCQIGQLDGYYAMQVADPVDQKREFVDDILSR
The following text describes a protein:
Function:
Putative ATP-dependent protease.
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MSRVLHPIFLFGKTSFLYSGCSKFGGRLFNNSIVHGWLRTRSYALASGLHPLRKQKLAHFEDLANANMSDPYMQAKLYKELADNFPEAIISRYETQGVARNSACDRYYQEALRKKSWSRSLSNNISLSQSSSSPATSSFSDPKAFSAGVPKFTSDTSSTVSSTPSLNHSLQNSMPPSTPTPPPVWAPTIVSSALGTSSKTPVYVVVDEPRFTKFFRIFKFIAGLSVASYFVLLGMSIFAETSGLNNIMTNTTEQEPMEERAINVRFSDVQGVDEAKEELEEIVDFLRDPTHFTRLGGKLPRGVLLTGPPGTGKTMLARAVAGEANVPFFFMSGSQFDEMYVGVGAKRVRELFAAARKQAPSIIFIDELDAIGQKRNARDAAHMRQTLNQLLVDLDGFSKNEDLAHPVVFIGATNFPESLDPALTRPGRFDRHIHVPLPDVRGRLAILLQHTRHVPLGKDVDLSIIARGTSGFAGADLANLINQAAVYASKNLSTAVSMRDLEWSKDRILMGAERKSAFITPENKLMTAYHEGGHALVALFTKNAMRPYKATIMPRGSSLGMTISLPDMDKDSWTREEYLAMLDVTMGGRAAEELLYGKDKITSGAHNDIDKATQVARRMVTEFGMSDRIGPVSLEAEMDNLSPATRALVESEIKSLLEASYERSLSLLKSHKKELDALATALVDYEFLTAEEMNRVVKGDRDLLRNKLS
The following text describes a protein:
Function:
Involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in heme and chlorophyll biosynthesis. Stimulates GluTR activity and regulates glutamate-1-semialdehyde release. May play a role in heme metabolism. Necessary for efficient photosynthetic electron transport in chloroplasts.
Subcellular Localization:
Plastid, chloroplast stroma. Note=Detected at low levels in thylakoids.
Sequence:
MQLQTQSFALNLLPSPNFAKPIERREFISLKRDPSRPISLRCSVSTTLDTPATASTHKPFPAEVSRSIMELSSVGTLSTLTHDGWPLGVGVRFAVDKDGTPVLCLNRSVSPDKRSALHVQLEQCGLRTPQCTIQGSIGRPGDDTVLKRLSATWREKFGEEVKEDSLYVVAVDRVLQMEDFMEDGIWVASSDYKNASPDPLRDIAEDIVNQINANNMEDIFRFCNVYVDLDFVVSETKMIWMDRLGFDLRVWSPRGVYDVRIPFPMEVTDEKGAKSSFNGMSQLAWEVEKSYCPADFNKVKLLKQVVGSSHSHKGGGQ
The following text describes a protein:
Function:
Transcriptional regulator essential for normal development and functions of the small intestine and spleen. Activates directly MADCAM1 expression. Required for homing of lymphocytes in spleen and mucosa-associated lymphoid tissue. May have a role during pharyngeal organogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MMLPSPVTSTPFSVKDILNLEQQRHFHGAHLQAELEQHFHSAPCMLATAEGTQFSDAGEEDEEEEGEKLSYLNSLAAAEGHGDSGLCPQSYVHTVLRDACSGPKEQEEEVVSERSQKSCQLKKSLEAAGDCKTSEDGERPKPRSRRKPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGTHAPPPPPRRVAVPVLVRDGKPCVTPSAQTYGSPYGVGAGAYSYNSFPAYGYGNSAAAAAAAAAAAAAAAAYSGSYGCAYPTGGGGGGGGTASAATTAMQPACSATGGGSFVNVSNLGGFGSGGGAQPLHQGAAAGSACTQGTLQGIRAW
The following text describes a protein:
Function:
May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Sequence:
MLLRATFTPIFTAIPYKSKIPAASLSISNAFLNNPLSVRENSSLNANATNQNPLLPPTSAYVHLPFCRKRCHYCDFPIVALGSSLSQTEDDDPRIANYVQLLCREIEATKVASNNNPPLETVFFGGGTPSLVPPRLIWSILEALRSKFGVCPDVEMSIEMDPGTFDTRKTRELLDLGVNRVSLGVQAFQKELLMACGRAHGIDEVYEAIDIISSCGLKNWSMDLISSLPHQTPEMWQESLKRTVESKPTHVSVYDLQVEQGTKFGVLYTPGEFPLPSETQSAEFYKMASETLSSAGYNHYEVSSYCKSGYECKHNLTYWQNKSFYGFGLGAASYTGGLRYSRPRKMKEYMGYVQNLEAGLVDNHGTDQIDAKDMAMDVVMLSLRTARGLEVKSFAGAFGSHLLASLCQAFQPYVESGHVVALNEERRELRPDEFGSALSSGQKIEEVLEFIRLSDPDGFLLSNELISIAFTVISP
The following text describes a protein:
Function:
GTPase that plays an essential role in the late steps of ribosome biogenesis.
Sequence:
MAKPIVAIVGRPNVGKSTLFNKLAGKRISIVQDTPGVTRDRIYAEAEWLNYKFTMIDTGGIEPKSEDIIVSQMRRQAQIAIEMANVIIFLVDGKEGLAPADKEVAQMLRKSKKPVVLVVNKIDKLKDENNAYEFYNLGIGDPVTISSSQALGLGDMLDRVVEYFKDDESAGEDDERINIAFIGKPNVGKSSLINKLLGEERLIVSDIPGTTRDSIDSYVDTDFGEFTLIDTAGLRRKSKVKEEIERYSVIRTYASIERADVCILMIDATEGISEQDQKIIGYAHDINKAILVIVNKWDLVEKDDKTMDKFKKELKVNLSFMPYAKYLFISAKTGQRVVKVLQTAKECYDNYNKRVKTGVLNDVISQAIMMKEPPIVGTKRLKIYYVTQIGTKPPTFIFFVNDPACIHFSYQRYLENQLRENFDFQGTGIKSEFRERKEK
The following text describes a protein:
Function:
Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.
Subcellular Localization:
Secreted, cell wall. Secreted, extracellular space, apoplast.
Sequence:
MEGSEYHIFNRYIGRYLTYIYIENKLEIERRKWIYLGDLLLLIDLLVLVSHVVADDFFNNVEITWGRSRGEIIDRGGLQQLSHDKISRSGFQSKQEYMFGRIDIQIKVLLGNLAERVTAYYIFLLSSILDGPFCTSPEPLFQLSDVSFQFAGTSRFLDGRYMDDVPIRVFRNVQEQLGVPYPKNQSQRVYSSLWNDDSWAIRSSLVKIDRYQALFTVSYQNFQTINACVFSNGKSLCRSTTSGLWRTTNLNASKLGKLQNVRKNNMIYDYYSDTRRFLHGLHCRRILHMNIYNL
The following text describes a protein:
Function:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
Miscellaneous:
MISCELLANEOUS: [Isoform Delta-RON]: Lacks part of the extracellular domain, oligomerizes and is constitutively activated. Expressed at higher level in cancer cells.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MELLPPLPQSFLLLLLLPAKPAAGEDWQCPRTPYAASRDFDVKYVVPSFSAGGLVQAMVTYEGDRNESAVFVAIRNRLHVLGPDLKSVQSLATGPAGDPGCQTCAACGPGPHGPPGDTDTKVLVLDPALPALVSCGSSLQGRCFLHDLEPQGTAVHLAAPACLFSAHHNRPDDCPDCVASPLGTRVTVVEQGQASYFYVASSLDAAVAASFSPRSVSIRRLKADASGFAPGFVALSVLPKHLVSYSIEYVHSFHTGAFVYFLTVQPASVTDDPSALHTRLARLSATEPELGDYRELVLDCRFAPKRRRRGAPEGGQPYPVLRVAHSAPVGAQLATELSIAEGQEVLFGVFVTGKDGGPGVGPNSVVCAFPIDLLDTLIDEGVERCCESPVHPGLRRGLDFFQSPSFCPNPPGLEALSPNTSCRHFPLLVSSSFSRVDLFNGLLGPVQVTALYVTRLDNVTVAHMGTMDGRILQVELVRSLNYLLYVSNFSLGDSGQPVQRDVSRLGDHLLFASGDQVFQVPIQGPGCRHFLTCGRCLRAWHFMGCGWCGNMCGQQKECPGSWQQDHCPPKLTEFHPHSGPLRGSTRLTLCGSNFYLHPSGLVPEGTHQVTVGQSPCRPLPKDSSKLRPVPRKDFVEEFECELEPLGTQAVGPTNVSLTVTNMPPGKHFRVDGTSVLRGFSFMEPVLIAVQPLFGPRAGGTCLTLEGQSLSVGTSRAVLVNGTECLLARVSEGQLLCATPPGATVASVPLSLQVGGAQVPGSWTFQYREDPVVLSISPNCGYINSHITICGQHLTSAWHLVLSFHDGLRAVESRCERQLPEQQLCRLPEYVVRDPQGWVAGNLSARGDGAAGFTLPGFRFLPPPHPPSANLVPLKPEEHAIKFEYIGLGAVADCVGINVTVGGESCQHEFRGDMVVCPLPPSLQLGQDGAPLQVCVDGECHILGRVVRPGPDGVPQSTLLGILLPLLLLVAALATALVFSYWWRRKQLVLPPNLNDLASLDQTAGATPLPILYSGSDYRSGLALPAIDGLDSTTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPSTSHEMNVRPEQPQFSPMPGNVRRPRPLSEPPRPT
The following text describes a protein:
Function:
Low-potential electron donor to a number of redox enzymes.
Sequence:
MSKKIGLFYGTQTGKTESVAEIIRDEFGNDVVTLHDVSQAEVTDLNDYQYLIIGCPTWNIGELQSDWEGLYSELDDVDFNGKLVAYFGTGDQIGYADNFQDAIGILEEKISQRGGKTVGYWSTDGYDFNDSKALRNGKFVGLALDEDNQSDLTDDRIKSWVAQLKSEFGL
The following text describes a protein:
Function:
May play a role in ribosome biogenesis, being required for integration of the 5S RNP into the ribosomal large subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MVAGKRTGAAKGSRHNKKYWRKGTNIDDIEDSIHIKSRQAATGGVISEMKDEDLFIVDRTATANKPVVPKLTKKQQAALEKITKNITQEHVTLPKPSTTSKILKKPAKLPRGNAILALKKGPKAAAPAAKKKNFDVWTTDLTPKIPKSKLENQEAAEHFLKVVKKKQPKTPGKSITSLLPAVQIAEGGASYNPESAEYQEYVAKIAGEEQKLIDHEAKIKAGIEPQWEKVTTEHERFLEMAEGLRIHPKYGKDDEEEEEAGNSEKSMKTGGEAEPKSQRVECDRMTKEQKKKKAKAQKLDKEEKRRLEEKAKEQDSHNVYRTKQLHKELDEEEKQRHEESEVRKKEKLINKLTKRQQLGKGKFVDAEDPFLLQEELTGNLRQLKPQGHVLDDRMKSLQRRNMLPIGGDKEKRRIKNRLKSKVVEKRSAKNIVKGSRVI
The following text describes a protein:
Function:
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKMWLLVSHIVIISFTTCLSEFTWHRRYGHGVSEEDKGFGPIFEEQPINTIYPEESPEGKVSLNCRARASPFPVYKWRMNNGDIDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPLPERTTKPYPADIVVQFKDIYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGTYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYSYHRGELRLYDVTFENAGMYQCIAENTHGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFLWSKGTERLVNSSRILIWEDGSLEINNITRNDGGTYTCFVENNKGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYNIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGIGEPSIPSNKIKTDGAAPNVAPSDVGGGGGSNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMRPSTAFQVKVKAFNNKGDGPYSLTAVIHSAQDAPSEAPTEVGVKVLSSSEISVHWEHVVEKIVESYQIRYWAAHDKEAAAHRVQVTSQEYSARLENLLPDTQYFVEVRACNSAGCGPPSDMIETFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGASILSPCLLGFLLPALGILVYLEF
The following text describes a protein:
Function:
Probable neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins (By similarity). Plays a role in the clustering of the GABA(A) receptor unc-49 at postsynaptic sites in neuromuscular junctions (NMJs) via the interaction with madd-4 and neurexin nrx-1 and is thereby required for normal GABAergic synaptic transmission.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Synapse. Note=Localizes specifically to GABAergic synapses.
Domain:
The cytoplasmic region is required for GABA(A) receptor clustering; The extracellular region is required for the localization to synapses and for GABA(A) receptor clustering.
Sequence:
MERIYLLLLLFLPRIRSYDVRSVTTSWGMVRGEVVSPEGDDLPPVAQYLGIPYGVAPTGQYRFNMAISAAKWTHMPKDARKVSPVCIQTDMPELSETKAFKHTSAQRFDFNHRLLPHLKKQSEDCLYMNIYVPERLEISRDNYLPVMVIVHGEEYGWGTGNAFNGTTLAAYGHIIVVTLNYRLGVFGFLGRCESSSCSGNSGISDLVSALTMLNVILPSFGGDSKSVTLAGWGSGASLVSLLMASPLTQPGRRLFRRAILLDGSALSPWAISQNPQQYFMQLAEELACAPKNRTSSFNDNVDTIVRCMQVHSSENITKAVLKIDVPTFLSGFAPIVDGQLIPNKPQVSFSTQYGSLFREIDLLVGISSNPSHHMISNEDLKVGISKEKRMRIFRSLVRNLYDFHREEILASIINEYTDWENPRDHPKSIRNGVLNALSDVLYTAPLIETLRSHSADEVRKEANTFMFAFAHETRSWSQEQPNSGIRGSLSGDIVPYIFGYPLAQGDSEERLYSGFNTDDKGISKVMMHYVSNFVKSGDPSKPNPMSKNFPMGDVFHSTAWPQFDQPNREAYLEITDRPRVKNYYRNAQVGFWNNFIPQLHKNGKETEPVGEEHHLLSDHFRKDSYFGKTRHFSSYANLPFPPPPMPPSPPPELTTKPKPSESPTTLQTTTESEKAAAGSFTGKALGGVIFIGCGFLIMNVCLLIAVRREWGKKRRNEKKFQLQYQTYNSNHGGGAEQYNSLNSPEPLLSASHKNSTSMRPAGISPTCPRHGRAALALQNSRGNSLTAAQAPTLEEIQV
The following text describes a protein:
Function:
Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
Sequence:
MEILFFGVKMKVRIKVKGIVQGVGFRPFVYRIAKKNNLKGYVKNMGNYVEILIEGKKEDIRNFINDLKNKKPPLSRIDKLDIEEIKGIEEFDDFYIIKSENAKDEEEGTIPADVAICDDCLKEMLDKNDRRYRYPFIACTNCGPRFTIVEKLPYDRENTSMRDFPLCEKCLEEYKNPLDRRFHAQATCCPICGPKVFLSDGKEIIAEKDEAIRETVKLLEEGHILAIKGIGGTHLACKVGEDDVVLELRKRLGRPTQPFAVMSKIEYTELFAEFDEDEKNALLSLRRPIVVLKKSQDYDKYFSKYVSNLDTIGVMFPYSGLHYLLFDKEIAYVMTSANLPGLPMVKDNDEILKKLNGIADYFLLHNRRIVNRCDDSVVKKVADRLVFLRRSRGFAPEPVKVNINNNKNILCVGAELNSTACIVKRDKFYLTQYIGNTSKYETFCYLRDAINNILRLTNTNKIDAIVCDLHPQFNSTKLAEELSEKFGAEIFRVQHHFAHAYSLLGDNNYFDDAIILSLDGVGYGLDGNIWGGEVLLFKDGKMERVGHLEEQYQLGGDLATKYPLRMLLSILYKAIGEEAFDFIKRYNFFSEKELRLLKFQLEKKLNCPITTSTGRVLDAVSALLGICFEKTYDGEPSIRLEPVANRFKGDINIEPKIKNNILNTTELIYKSYEMLLNNENKEKIAHFAHIYIADGLFEIAKKISNKFGINTIGITGGVSYNKIITERIMNNAKREGFNFIYHQRVPNGDGGISFGQGVAYILKNGY
The following text describes a protein:
Function:
Probably regulates the expression of genes from the sulfate permease complex.
Subcellular Localization:
Cytoplasm.
Sequence:
MFVNSSPIADGLSALVGLDSQPLQFYERGDVVPPKDQGCWQIYRGILQVSQWTLGGDEVLMGWAQPGSFVGLDFSAHQRETYQIRALTDVYLRGYSLEMITNNANLCRLVLDQTLQQVRQREALLAIAGYKRVDERLQGLLNLLGQELGQPGTGGMRLSVRLTHQMLANAIGTTRVTVTRLLGEFQTQGKVSLDGDRHLVIALGN
The following text describes a protein:
Function:
Probable cyclase; part of the gene cluster that mediates the biosynthesis of ochratoxin A (OTA), a mycotoxin composed of a chlorinated type I polyketide dihydroisocoumarin moiety linked to L-phenylalanine, and demonstrated to have nephrotoxic, immunotoxic, genotoxic, neurotoxic, and teratogenic properties. OtaY is probably involved in the polyketide cyclization (Probable). The pathway begins with the highly reducing polyketide synthase otaA that catalyzes the formation of the isocoumarin group during the initial stages of biosynthesis, starting from one acetate and 4 malonate units, to originate the characteristic pentaketide skeleton 7-methylmellein (7-MM) of the OTA molecule. The newly identified cyclase otaY might be involved in the polyketide cyclization reaction during the initial steps of the OTA biosynthesis. 7-MM is then oxidized into 7-carboxymellein (also called ochratoxin beta) by the cytochrome P450 monooxygenase otaC. The NRPS encoded by the otaB gene is involved in the linking of phenylalanine to the dihydroisocoumarin ring. The reaction catalyzed by NRPS results in the production of ochratoxin B (OTB), which is the non-chlorinated analog of OTA and which subsequently serves as the substrate of the halogenase otaD for chlorination activity to form the final molecular structure of OTA, containing a chlorine atom in the C-5 position of the molecule (Probable).
Sequence:
MDLKSRAETFLTTIVNRRETASIEHYLHPDAQFKHNDLPSMSTAELLAFWPQVLDESPDFRVQILATIAEGLRVWVYSRVEGRLGKGVMDDVHMLEFDGNGLLIRSRGIQREVVEEMEK
The following text describes a protein:
Function:
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
Subcellular Localization:
Secreted.
Sequence:
MAGKAAWFLPLLAAGLALLARDAGAALCEPITIPMCKKMPWNMTRMPNLLHHSTQENAKLAIEQYESLVNFQPSCSPDLLLFFLCSMYAPICTLEFSQEPIRPCKKVCEGARAACEPVVLAYNHTWPDHLKCDDLPVYELGVCISPEAIVTEEPPELVGPESTDSAEIREPGKSGNGRRKQEGLDEEDAVGFEYDDDVYESDDNNEKCPKCKRLKASYRNFEKKTYHYVLRVLVKGTETRGDQIATTVNVLEEWKHHAISVPKGEVQLWTNSTCKCPRLKVNQEYIIMGYEDSTKGRLLLLPDSMITNYSSRWQKRFKKWERRLKRPSGRKRRKGRKKPQGDSADPQSSRERRETDTGRLRRHNMEHGNES
The following text describes a protein:
Function:
Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes to glycogen granules (glycosomes) in the cytoplasm.
Domain:
The length of the linker region between residues 387-394 which separates two alpha-helices regulates the size of the glycogen particles synthesized but plays no role in the interaction with gsy-1.
Sequence:
MSEAWITLATNDNYAQGALVLVHSLRTAGTTRKIHCLISNEVSAPVRKQLEEHFDDVSIVDVFNSNDSDNLRLIERPDLGVTFTKLHCWRLTQYTKCVFLDADTLVLRNADELFTRPDFSAASDIGWPDSFNSGVFVYVPNNETYRQLVDFAVTHGSYDGGDQGLLNDFFSNWRDLPSEHRLPFIYNMTAGAFYTYAAAYKRYGANTKIVHFIGSVKPWHGSAAVHTGEHFQQWQKIYHAHVNHTSRTNEHAAVFPSHHHTPEHRSHSADHPKIERKDSIVREIGNFVMHVVQSVNILPSYDTDANTSDSHRNNEPHKHDQQREEHHELPHNKFQTPHEESQDIVGSTDCFGSQMPKYNADSETDREVEQITNNTPCPAFVPFERREEYQAASPSTEERRAAWEAGQPDYLGRDAFVHIQEALNRALNE
The following text describes a protein:
Function:
Receptor for ATP that acts as a ligand-gated ion channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MPACCSCSDVFQYETTKVTRIQSMNYGTIKWFFHVIVFSYVSFALVSDKLYQRKEPVISSVHTKVKGTAEVKEEMVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNRKTCEVSAWCPIEAVGEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTATVFIDFLINTYSSNYCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQKLLGRSLQDVKGQEVPRPAMDFTDLSKLPLALHDPPPIPGQPGEMQPLREEATPRSRDSPVWCQCGSCLPSQLPKSHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
The following text describes a protein:
Function:
Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.
Miscellaneous:
MISCELLANEOUS: Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and mammals such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig can ovulate in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the number of follicles that go onto ovulate during each reproductive cycle are poorly understood. According to PubMed:21970812, mRNA expression levels of GDF9 and BMP15 are tightly coregulated within each species and influence species-specific ovulation-rates.
Subcellular Localization:
Secreted.
Sequence:
MARPNKFLLWFCCFAWLCFPISLGSQASGGEAQIAASAELESGAMPWSLLQHIDERDRAGLLPALFKVLSVGRGGSPRLQPDSRALHYMKKLYKTYATKEGIPKSNRSHLYNTVRLFTPCTRHKQAPGDQVTGILPSVELLFNLDRITTVEHLLKSVLLYNINNSVSFSSAVKCVCNLMIKEPKSSSRTLGRAPYSFTFNSQFEFGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCMKDQLEHPSAQNGLFNMTLVSPSLILYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEEAAEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR