lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R. Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism. Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (By similarity). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation. Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase. In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (By similarity).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MASAPLPGPPASAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGTGGDEASAAGGSPPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRSGEGGSGTTGGSCSASLPGVLGGSAGAAGCDDNYGLVTPATAVYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCTSCRVRTASEGDGGAAGGAGTAGGRPMSVAGSPLSPGPVRAPLSRSHTLSAGCGGRPSKVTLAPAGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPLPPGSHPHLPHPLHHPQGQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFSSHRSNTPESIAETPPARDGSGGELYGYMSMDRPLSHCGRPYRRVSGDGAQDLDRGLRKRTYSLTTPARQRQVPQPSSASLDEYTLMRATFSGSSGRLCPSFPASSPKVAYNPYPEDYGDIEIGSHKSSSSNLGADDGYMPMTPGAALRSGGPNSCKSDDYMPMSPTSVSAPKQILQPRLAAALPPSGAAVPAPPSGVGRTFPVNGGGYKASSPAESSPEDSGYMRMWCGSKLSMENPDPKLLPNGDYLNMSPSEAGTAGTPPDFSAALRGGSEGLKGIPGHCYSSLPRSYKAPCSCSGDNDQYVLMSSPVGRILEEERLEPQATPGAGTFGAAGGSHTQPHHSAVPSSMRPSAIGGRPEGFLGQRCRAVRPTRLSLEGLQTLPSMQEYPLPTEPKSPGEYINIDFGEAGTRLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPSTRSGDTVGSMDGLLSPEASSPYPPLPPRPSTSPSSLQQPLPPAPGDLYRLPPASAATSQGPTAGSSMSSEPGDNGDYTEMAFGVAATPPQPIVAPPKPEGARVASPTSGLKRLSLMDQVSGVEAFLQVSQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHNSKRHNSASVENVSLRKSSEGSSTLGGGDEPPTSPGQAQPLVAVPPVPQARPWNPGQPGALIGCPGGSSSPMRRETSVGFQNGLNYIAIDVRGEQGSLAQSQPQPGDKNSWSRTRSLGGLLGTVGGSGASGVCGGPGTGALPSASTYASIDFLSHHLKEATVVKE
The following text describes a protein:
Function:
May be a transcription factor which play a regulatory role in the development of the embryo.
Subcellular Localization:
Nucleus.
Sequence:
MNGFSQQLEDFYPSYFSPSPLGFSEPEVQPVAMNLVPTIQKDIQQQPNRKEVTKIPRASEQSPVQNVRPKEAINTKEADSRNPEPDSSLVSASQRRKRTFFTQAQLDILEQFFQTNMYPDIHHREELARHIYIPESRIQVWFQNRRAKVRRQGAKATKPALASHHYSSTSGAMFPSAPAPNSSSYQMTSSRAQVQPPKEYQLNKFHQSQGFLSYPDSSSDVSRQRFLLSQATPGVYHLPQASSNVYDQNVKSNDPLWGQQQVYTNMESVLNLSRRPQQMPAQPMFMNSFQTNKIIKSKMDTTSPPIPVSTTSSHHSQMSLFAGQDPCHMSTAPGGTYGQISPISDSGVSDTSPEPSSDWEENVSVLLHL
The following text describes a protein:
Function:
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence. Enhances the DNA binding of OBF transcription factors to OCS elements (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MQDIHDFSMNGVGGGGGGGGRFFGGGIGGGGGGDRRMRAHQNNILNHHQSLKCPRCNSLNTKFCYYNNYNLSQPRHFCKNCRRYWTKGGVLRNVPVGGGCRKAKRSKTKQVPSSSSADKPTTTQDDHHVEEKSSTGSHSSSESSSLTASNSTTVAAVSVTAAAEVASSVIPGFDMPNMKIYGNGIEWSTLLGQGSSAGGVFSEIGGFPAVSAIETTPFGFGGKFVNQDDHLKLEGETVQQQQFGDRTAQVEFQGRSSDPNMGFEPLDWGSGGGDQTLFDLTSTVDHAYWSQSQWTSSDQDQSGLYLP
The following text describes a protein:
Function:
Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis from both N-acyl-lysoplasmenylethanolamin (N-acyl-lysoPlsEt) and N-acyl-lysophosphatidylethanolamin (N-acyl-lysoPE). In addition, hydrolyzes glycerophospho-N-acylethanolamine to N-acylethanolamine. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine.
Subcellular Localization:
Cytoplasm. Membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Concentrated at the perinuclear region and the cell periphery.
Sequence:
MSSTAAFCLLSTLGGYLVTSFLLLKYPALLHQRKKQRFLSRHISHRGGAGENLENTMAAFQHAVTIGTDMLELDCHITKDEQVVVSHDANLKRSTGVNVNVSDLKYCELPPYLCKLDVPFQRACKCEGKDTRIPLLKEVFEAFPETPINIDIKVNNNVLIKKVSELVKQYKREHLTVWGNANSEIVDKCYKENSDIPILFSLQRVLLILGLFFTGLLPFVPIREQFFEIPMPSIILKLKEPHTISKGHKFLIWLSDTLLMRKALFDHLTARGIQVYVWVLNEEYEYKRAFDLGATGVMTDYPTKLKDFLNNFSA
The following text describes a protein:
Function:
Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
MGPYEGASSAQQNNGSRPPHNQMQGHPSQQQPPQHGGGGGQMPPNGHHQMGNPYGGYHPLNMQQGGQPQQQQNGMMGGGGGVTMGGFNMQGSNGGMSMGGNNGQQHRGMHPMSMQSGGGGSQYGGPGGGGGNNNMYNHPNFNSGNQPGGGGHHHGGYNPHQQQIQQQQLGGYNPQMMAQMQQSHNSQYNPMQQMGQRSHQQQQQHQGGYHPQPQIPLPQAQAYGQQQQQLHPSNSYARQASSASIHSSIAVANDSSPSPSDNMQLLSYKEAPNFSEVTGVDIGDEDYGQQFLPTGLNGDWQSDRDMHHRREMIQHIVKLLKQKDKSASPEWLTKLPQMVKQLEVSLYRSAPSFEAYSDTNTLKHRLQQLAMEIARKTQQAKASGRSSSRGDRIPGMGNMHYNPVNMGANEEIVSSQYGNPNDPEWKVRIRHKQQRLLLLHHSSKCPYDNDKCKVTPYCGEMKKLWKHMARCTDNECRVPHCFSSRSILSHCRKCKDPGCPACGPVRETVRKTQKSNAGKGVNEGQGDFGGMGPNSGIGLGGMGNEMGGGGGSGMGGNDMMGGMPMMGGNMNQMPKRQPSQPMPWKGDINSMPNFPPPNIRQQQDDYMAFPEGFPEGQQVLNGPSSGQSGNPESSKARHKQQRLLLLRHASKCNAEPGRCTTTPHCAEMKVLWKHIANCKDQYCKVKHCMSSRYVLSHYRRCNDPGCEICGPVREIFKSGTNHFIHDPSFMPGSSAADLITPPLPEGPQTKRSRTNDPSMNGMHHTAPARPAFPLSAPTSGSENHAKLKSSAKPSSSNATEEHSLLECFTTEQVKTHIQSLKKTIEVSPAKLKLKCVEILRELQIHEHGWVFATPVDPVELGLDDYFDVIKKPMDLGTISRRLDNGSYHAFDDFKSDVRLTFENAMKYNDENSVVHEMAKELKKKFDTDYKKLMKQLEKEHRENSMRQQACGLCGCEKLNFEPPVFFCNGMNCPSKRIRRNTHFYITADKQYAWCSQCYNELGGEIDLGTSVLKKVDLAKKKNDETHEESWVQCDDCERWIHQICGLYNTRQDKENKSAYSCPLCLLDKRKKEGEPKKLPPPPAASDIPRTNLSDWLERDVHKKVNQRLKELAQEKADTEHIAFEKAYADLSAGGPLTIRQVTSTDRKLEVRDQMRQRYAHKNYPEEFPYRCKCIVVFQNIDGVDVVLFALYVYEHGDDNPFPNKKTVYVSYLDSVHFMKPRQMRTFLYHEILISYLDYARQKGFLQAFIWACPPLKGDDYIFYAKPEDQKTPKDVRLRQWYLDMLVECQKRNIVGMVSNMYDQYFANKSLDAASVPYFDGDYFPGEAENIIKDLEESNSKRKGGAGKKNKDPSKSKAAPSGDAEFVGEKCYKEGGRDPVMQKFCDAIQGMKESFIVAYLNAKDAKPEHLVVPKKIMEFREANKLLMIDDDPKKKKEDGTEEKKDDEKPQSKKRDADGYEVAASEKPPANKQLNSKGKPVRVLNDDDEEIDCEFFNTRQCFLDLCRGNHYQFDELRRAKHTSMMVLWHLQNREAPKFVQQCMACNREIASGIRHHCNVCSDFDLCDDCFRDPDTNRGTCNHKLEAIKVDTAQSENSGLTEEQRKERQRNIQLHITLIEHASRCNSSSCKSSNCMKMKSYLKHGSTCTVKASGGCKICKRIWTLLRIHAQQCKSSSCAIPQCIAIRKRIRQLQLKQQAMDDRRRQEMNRHYRMGMMSSDN
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cell membrane; Single-pass membrane protein. Cytoplasm.
Sequence:
MDSSDSSCQEWCSHGQYWLELGPTDLMERKGSLTLRSHHKKYSKPVLVYSWHRDRETYPKDYDIEGPEEVKKLCNSTYRRLGTSEPPVWISETREKMAQVCLNTKLAKIKSKALLNEETMNSGIIERDTGLPATGFGALFTRHSPDWSKMCTLTTYAEEYAPPYEYQPLGDPCQDDDYSIVHRKCRSQFTDLDGSKRVGINTWHDESGIYANSYVKRKLYSLTGGPIAPFLK
The following text describes a protein:
Function:
Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.
Subcellular Localization:
Nucleus.
Sequence:
MGGRKRTFKVLKKPKTMKPRAYFDCAVCGWKDCIIIKIKKCYKTSKLECERCETKFDMKVRSLDEPIDIYHEWLHKLKTKAITPYPNRMQDEYDDTGDEANENDVEQLLKNQKGKKNKRKRIKRNASEEDMSSKNDKVSDSEEALDRDQDISEDSLLNKQKVEDNIDDNQEDEKENDQEDEKEDSEDESYNIKEQYKRKRGKKK
The following text describes a protein:
Function:
Binds specifically to the plant telomeric double-stranded DNA sequences. At least 2 repeats of telomeric sequences are required for binding. Induces DNA bending.
Subcellular Localization:
Nucleus.
Sequence:
MVFKRKLDCLSVGFDFPNIPRAPRSCRRKVLNKRIDHDDDNTQICAIDLLALAGKILQESESSSASSNAFEEIKQEKVENCKTIKSESSDQGNSVSKPTYDISTEKCVVNSCFSFPDSDGVLERTPMSDYKKIHGLMDVGCENKNVNNGFEQGEATDRVGDGGLVTDTCNLEDATALGLQFPKSVCVGGDLKSPSTLDMTPNGSYARHGNHTNLGRKDDDEKFYSYHKLSNKFKSYRSPTIRRIRKSMSSKYWKQVPKDFGYSRADVGVKTLYRKRKSCYGYNAWQREIIYKRRRSPDRSSVVTSDGGLSSGSVSKLPKKGDTVKLSIKSFRIPELFIEVPETATVGSLKRTVMEAVSVLLSGGIRVGVLMHGKKVRDERKTLSQTGISCDENLDNLGFTLEPSPSKVPLPLCSEDPAVPTDPTSLSERSAASPMLDSGIPHADDVIDSRNIVDSNLELVPYQGDISVDEPSSDSKELVPLPELEVKALAIVPLNQKPKRTELAQRRTRRPFSVTEVEALVQAVEELGTGRWRDVKLRAFEDADHRTYVDLKDKWKTLVHTASISPQQRRGEPVPQELLDRVLRAYGYWSQHQGKHQARGASKDPDMNRGGAFESGVSV
The following text describes a protein:
Function:
Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, myofibril.
Sequence:
MLGIIPRLGEFESPDISIDDIASFYSLGTAVVPKHIPYTWTNSVTTLDGILHFGDNSLVSDVALKHAPGIGHWSNADWRLLNAGWAHADAVLITGEILRKEKEAGCIVQFDDLIRYRLNVLGKLDAQPIQVVVSSMCDFELDRPLFMGSGNQDGAKLQVWIITTALGAASLENRLRPFRESGKLESNVTVMIGDTLHTTIKPRVDLIWVFKLLRAKGVEYLDVSAGGSVIRKCIDLELLNETRLTIAGHVAGPFDMSGNKRPELFPIDSDRFKSYPPDKSPLFAMRALRTAGDYLDGTDSTTADFVQSAPLLPVNGLQVHTLDRLLFCSVCNELKCDGCVSQEVSCCYCPNCMFEVPTTSIKTERGSCGRNCFNCPICGCITTVTNAAAQEGSGTDAQIVGGAYYLSCSTCRWDSTECGLRFERPTGLAAHISKLDSDSPQIKEYDHLLEHYIETMRTFRSSGVGSGDLASSLGSHVFGSLHSSLGLLNSSIRLLRIKPDRRVLAYEPKSKPSTQPVDAVATFLGIPYNERTSLEQRLRQSNGTSIIDINQLRPERVQLRSKRNKRCLKCEHILVKPETKAASTRFGIKMAARDKIPRIQITPPLPLSPIEVGREFTMHLRFVNPLSSSVYIDLETRSAASSLCTVQLHTSNLTLDAYTDPWEIPETVVRSSSTPISINSAAGGHLPMNFEACAVTGPHEQIVVLSVTPLKFESEIHFPIQVNFTTKVESHEAGESTDTSDVSKVTKDPVKQRISFWIVVGVGKSGPHPTVNTENTDHT
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls development of mouthparts, and labial and maxillary palps.
Subcellular Localization:
Nucleus.
Sequence:
MQEVCSSLDTTSMGTQIKSESPLNPLQVQTGQTSLPVGGCGGAGVVGGVGGVGVSVGQPGIGQQGVPPVPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFLNHLSPESPKIGTPVGSGAIGGVGVNVNVNVGVGVGYPVGVVPQTPDGMDSVPEYPWMKEKKTSRKSSNNNNQGDNSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQTLSKTDDEDNKDSLKGDDDQSDSNSNSKKSCQGCELPSDDIPDSTSNSRGHNNNTPSATNNNPSAGNLTPNSSLETGISSNLMGSTTVSASNVISADSSVASSVSLDEDIEESSPIKVKKKDDGQVIKKEAVSTSSKASPFGYENSTPSLVSFRRDSDASAVGNAPTSKAVGKKRFQSAANAIATPTPLSDSNSGNGSGGGPAGGYFPGYYPSPKQQQQVQQQQLHPQQQQLPQQQPQDYYGKYDIEFAASPHHNPHNKQQALHGEYLSPKPSSANFHQNSQQQQQNDHFYYNYNDTNGTPYLNHQQQHHHHAQHHQQQQHHQNHVADFEGPVNGPSNFNNGAYYDNMSFQQQAQAHQHQTVVFQQQQPHQPAAINHQHMHHLGNGETYSALGLQMENCEGYNNFGAAGTGGGYYEAGQQPPIPATHGHGHHPHHVQVPAQAHAPIHAHHNSAAIPGGVGVGPPPSHIHGFAINGGPAVQGQAFGNNGSTAAGTAAISGLENSNSSDFNFLSNLANDFAPEYYQLS
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MTRADGGTGDANSGRYNLADELLLLQDEPYIISQELGVDDMNASEQLSTLDGAIDAITSSPDNVSNSDIYDLIRSYLKHFANLCPNACNKLLDVIASGMSSALDEAQRELDGDDPNAYTSHAETLERYAFLLQWLVSVAEKYSGARSDNGGSAAAIVAARGVSASRRGGASAKSAAAAAAAAKSGSARADAWAWSNSIPAVLTLMSKAARVRSERMWTVSAARDSFVSGCLLRPALLLQENELYLKSQPIKLGIFKVICQAVKAHGQAFSAQTSIMQSLQYYEHLAEPMAELLAVMRLEFDYERLGEDVLREVAAKNFGAMDTKSPRSFGRFLVRMAELSPRSVLKQISLLQKHLDSESYPMRNALIETLGLLIKELALTDDSLNSDGGDAGISGDAAADENRGSAEARKKQIETFFDLLIERFLDLNSYVRSKLITVCARLLDLPTKFPKQRTEITEMVIRHLEDKSSGVRKNAIALLTKLILTHPFGMLHGGELCLQEWQARYDLVSKELQETEGSLNLPGERSLDRDESESEAADDLDEDMDEDRDDVEEQQDGDDTVMQDNDESDDQDAPPSRNRHSSKKSKDKAQHSKPKKARRSGVDLEALATAQAEMEPVDAEKVMRLRLTKRYYTDAIAFITQIETAMPNLTLLLASTNKAEVLESMEFFRVAHEYKLSGSAQGVRKMVHLIWTKDNTLVMEDGIQLKGVRSRLIEVYRALYFDARADLNAKDNIARIAKNMIERTFGATLAELTSLEEMLKTMQIENLVHPEVVNKLWAVYSAPRAISAAQRRGAIIVLGMLATARREIISEHVDTLLRVGLGPLGARDVILAKYTCVALQRLGGSVKKVKGALSDESVRYPMTHALFGRLRAAIQMSGDVLKGNSRAEWFSLAENAINTIYLLGEQPDALCTDIVRSMTSRVFGSNTGKSNRQEDDAAASEASMSDARDVASSSDTPIMGDAFQLAQLLFLVGHVALKHIVYLELVEREYKRRKAEADKEKAVAKAVSQGKASRAAAAAAAAAVEELDQVAGNAEDEIGEVIASVREKELLYGSRSVLAMFGPIITHICSSPKSYPNELVRRAAVLTLCKFMCVSSTFCEANLALLLHILTTSKDAVIRSNVVIALGDIAVCFGSLVDENSDRLYAGLADSDLSVKKHTLMVLTHLILNGMIKVKGQLGEMAKCLEDPEPRVSDLAKLFFSELATKENAVYNNLPDIISHLSIGKHAVDEETFARTMRFIFTFIDKEKQAENVVEKLCQRFRLTSSERQWRDIAFCLSLLPYKSERSVKKLIEGLPFYQDKLYHAEVYKRFQEILAKARANKTAASGGGGGRVANGGAAGASSEGAGDLREFEEILAQAAAKGEQDEAFEGAAHAKVAKLTRARKSGKPSNAAAAKKSTRASTRVSVASEA
The following text describes a protein:
Function:
Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEDSASASLSSAAATGTSTSTPAAPTARKQLDKEQVRKAVDALLTHCKSRKNNYGLLLNENESLFLMVVLWKIPSKELRVRLTLPHSIRSDSEDICLFTKDEPNSAPEKTEQFYRKLLNKHGIKTVSQIISLQTLKKEYKSYEAKLRLLSSFDFFLTDARIRRLLPSLIGRHFYQRKKVPVSVNLLSKNLSREINDCIGGTVLNISKSGSCSAIRIGHVGMQIEHIIENIVAVTKGLSEKLPEKWESVKLLFVKTEKSAALPIFSSFVSNWDEATKRSLLNKKKKEARRKRRERNFEKQKERKKKRQQARKTASVLSKDDVAPESGDTTVKKPESKKEQTPEHGKKKRGRGKAQVKATNESEDEIPQLVPIGKKTPANEKVEIQKHATGKKSPAKSPNPSTPRGKKRKPLPASETPKAAESETPGKGPEKKPKIKEEAVREKSPSLGKKDARQTPKKPETKFFTTPSKSVRKASHTPKKWPKKPKVPQLT
The following text describes a protein:
Function:
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of DIF-1 (Differentiation Inducing Factor-1), a signal molecule involved in the differentiation of pstO (prestalk-O) cells. The three-step process begins with the formation of (2,4,6-trihydroxyphenyl)-1-hexan-1-one (THPH) by the polyketide synthase StlB. THPH is then dichlorinated by the flavin-dependent halogenase ChlA. The last step of DIF-1 biosynthesis is the O-methylation of dichloro-THPH (or des-methyl-DIF-1) by the methyltransferase DmtA to yield DIF-1.
Sequence:
MISNSDCDENLIKQQQQEIQDKNFLIDVAIGYTKSNALSCALKYKIPQLLEDKSKSCKELSEILKVNCDNLYRLLRTLSTIGIFIEDEVEDGVFRNSRLSNLLRNSNSDSWVNNVYLQSHPNVIQSFMYLDKTIECGTSQGMTSQGFSSAWELFEKDKSLNAHFHNTMTSFTSDEIKTILEYIDFNQYKSIVDLGGSSGELLKSIAKSSRGQLVESFINFDLPLVINQNKVNNENGAAEFDKRYSEVASDLFVDSDYPSADCYTLKFIFHMFNDDKVLTILDKISKSIKPNGKVYVFDHIVQPKNQPYAPFYFDLQMIVNFNGKERSQNEWKTIFEKSPFKIDTILILPDSKRMSVIELSLKQ
The following text describes a protein:
Function:
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MERLVIRMPFSHLSTYSLVWVMAAVVLCTAQVQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNSTITFWNITLEDEGCYMCLFNTFGFGKISGTACLTVYVQPIVSLHYKFSEDHLNITCSATARPAPMVFWKVPRSGIENSTVTLSHPNGTTSVTSILHIKDPKNQVGKEVICQVLHLGTVTDFKQTVNKGYWFSVPLLLSIVSLVILLVLISILLYWKRHRNQDRGELSQGVQKMT
The following text describes a protein:
Function:
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
Subcellular Localization:
Cytoplasm.
Domain:
Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
Sequence:
MISGLKGTLKKLEVGFVHIETGGITYEVTISFKTYLELKNLPLLKEVQLQIFHSINERGQKLFGFLTEQDKEFFKVMKGLQGIGELTALKILSFFSAEDLYRIVQSGEAKELEKIPKVKGKTSEKIFFEVKQNLKKLELFLSGSSKESSVILTSLLQSPEEMAFSKKRETVILGLVQLGFEEKTASKEVDKVLKIFSSNDPGEIIREILKSL
The following text describes a protein:
Function:
Cyclopeptide antibiotic that inhibits the growth of Gram-positive bacteria, but has no effect on the growth of Gram-negative bacteria.
Subcellular Localization:
Secreted.
Sequence:
MLYELVAYGIAQGTAEKVVSLINAGLTVGSIISILGGVTVGLSGVFTAVKAAIAKQGIKKAIQL
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Cell membrane. Endomembrane system; Multi-pass membrane protein.
Sequence:
MASEKVETVVAGNYLEMEREEEGSKSTTSKLSRLFWHGGSVYDAWFSCASNQVAQVLLTLPYSFSQLGMLSGIIFQLFYGLMGSWTAYLISVLYVEYRTRKEREKVDFRNHVIQWFEVLDGLLGKHWRNLGLFFNCTFLLFGSVIQLIACASNIYYINDNLDKRTWTYIFGACCATTVFIPSFHNYRIWSFLGLVMTTYTAWYMTIASLTHGQVEGVTHTGPAKLVLYFTGATNILYTFGGHAVTVEIMHAMWKPQKFKMIYLIATLYVLTLTLPSASAVYWAFGDQLLTHSNALSLLPKTGFRDTAVILMLIHQFITFGFACTPLYFVWEKFIGVHETKSLFKRALARLPVVIPIWFLAIIFPFFGPINSTVGSLLVSFTVYIIPALAHMVTFASAPARENAVERPPSKLGGWVGLYSMNVFVVVWVLVIGFGLGGWASMINFIHQIDTFGLFVKCYQCPPHKA
The following text describes a protein:
Function:
Probable amino acid transporter of unknown specificity.
Miscellaneous:
MISCELLANEOUS: Present with 195 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MEATSSALSSTANLVKTIVGAGTLAIPYSFKSDGVLVGVILTLLAAVTSGLGLFVLSKCSKTLINPRNSSFFTLCMLTYPTLAPIFDLAMIVQCFGVGLSYLVLIGDLFPGLFGGERNYWIIASAVIIIPLCLVKKLDQLKYSSILGLFALAYISILVFSHFVFELGKGELTNILRNDICWWKIHDFKGLLSTFSIIIFAFTGSMNLFPMINELKDNSMENITFVINNSISLSTALFLIVGLSGYLTFGNETLGNLMLNYDPNSIWIVIGKFCLGSMLILSFPLLFHPLRIAVNNVIIWIEITYGGANPEEDPQVSEYTRASNLRPISMTVEDPAQPSDALDATSYNEQECLLPNGNFDNGSIESQENNNDERGTMAVAGDNEHHAPFVKSRFYWITALLLISMYTLALSVQSFALVLSFVGATGSTSISFTLPGLLGYKLIGLDSLAIGKMIPPKDRFYKRCSLLLVFYGLSVMFLSLYVTVFNRSDEA
The following text describes a protein:
Function:
May have dioxygenase activity.
Sequence:
MKNEKLKVDNHIHNNIQFIDCLEFWVSNAKSFIKSFLQPMNFEVIGTRFNDERSRIQYLLLNNVISRSNLQNQFQIENNSYIKPIQGNQFIKVTSSISPNDLDFHSKIQKHGDFIQNISFYCNDINLAYNKSINNGAKSVQLPMKEYFKNCKDIVETAIIESPFKDLQHTFINRNITSFDDNNNNNYDNNKEIFGNPLFLYPEFQEIKDKELFKIEKEDSSSINGCTGSLDHIATCIKNGEMNYFVEWYRKCLGFKLLSDKDSVATDESENFENELILDKNFYVITKSDFKYTKKENIGLKMAVLSNQPLNTSFHKTPPIQFVISEAIQGGEGQIEQFIHYFGGEGVQHLAFNSNNIFKAVEIAKSQKLEFVYIPQSYYSKLDERLKHLFPNSIPKILKENLMKFGILIDSDAITNTNENNSNNNNNNDSQNNTEINQNIGYIKQIFTKYINDRPTMFFELIERSNALGFGKGNIIALFESLEKESSGSQLKSD
The following text describes a protein:
Function:
Transcriptional regulator of iron-responsive genes. Represses expression of SEF1 and genes for iron uptake if iron is present. Plays also a transcription-independent role in the direct inhibition of SEF1 function through protein complex formation and translocation to the cytoplasm, where SEF1 is destabilized. Promotes gastrointestinal commensalism in mice.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPTSPTESIPNSSTKEQPILPKMLPTAKSPHTTPAQSPQNSDHHHHHQQTPPQPTDGQQCSNCGTTKTPLWRRAPDGTLICNACGLYYRSNNTHRPVNLKRPPNTIAVVKEEEGSCKGDGRCNGTGGSAACKGCPAYNNRIVAKKALEKSPKNDSSRAPIDKSLKRSTSTDATTEDESSLAIACFNCGTTITPLWRRDDAGNTICNACGLFYRLHGSHRPIKMKRPTIKRRKRNVSDKKSKDEVQMHSSDQSPIVASDPISPTPHNNENNNNVTNITTTTKTPTRSPHYYQPPPQYPYQHHPINSTTSSAINRLPPISYQSPYQTAPLSHSPMQSSSSYSPGASSVIPSSYYPPYSGSGRIPNGPGPVPGPPPPPPPTQSQPHHQQITTSPTSQSYGSLRAPIHITKRGYTPENIRLPSIQLTSSTSSNSETKLPPITNHSEKCCSNCAGPKSLAPMAIDFTASYRFNNIDSQTKLTKEDQNDSEGVSRDNDTRDENKPIKQEEHRSALSIGKLLNG
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSAFVKTVCLAQKLCAANPVVARQAIRSMAGWNKDYKPGPYPQTEKERLAAAKKYYLLPEEYKPYADDGLGYGDYPKLGYGLGVEAKDSYYPWDYPEHKRNQHEPISADHDLYSEDRWSQAEPPRYSNAYYFACFLGVMSGCLALYYWLDDKKMYRPVAAKQYPSPGVKHYTFEK
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins during protein synthesis.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MAFRQRTSPAAFPSSVVLGNRWPVLALQAAFLVSFVTCNDAPPVPDDQLHIEKRWVPDTCQRHVTEGDFVRYHYHGTFPDGTKFDSSYDRGSTYNVFVGKGQIIAGMDKALLGMCVNERRFVKIPPTLAYGSKGVADVIPPDAILHFDVLLLDIWNPTDTVQVETYYKPENCTRQVEVSDFIRYHYNGSLMDGTLFDSSHNRMRTYDTYVGIGWLIPGMDKGLLGMCVGEKRLITVPPFLGYGEDGDGKDIPSQASLVFDVVLLDLHNPKDGITVESHYVPEDCERKTQVGDFIRYHYNGSLLDGTFFDSSYSRKRTYDTYIGKGYVIAGMDEGLLGLCTGEKKRVIIPPHLGYGEEGKGKIPGSAVLVFDIHVIDFHNPQDSVGIVSLFKPSNCSVLSKKGDYVKYHYNATLMDGTVLDSTHQYGKTYNIVLGSGQVVMGMDIGLQDMCIGEKRSIVIPPHLGYGEAGVEGEVPGSAVLAFDIELLDLIPGLPDGYMFVWNGEVSPNLFEDIDKDKNGEVVLDEFSEYIDTQVKVGKGKLAPGFDANKIIENMFTNQDRNQDGKITEEEFKLKDQEDKEIHDEL
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MASCNLLVIQTTSIIMFSSLLSRPVNSSYDPSYHFSPVTREIKNDPTSNGVVSTTKNATPLAPSKYDTTIPLKKRYPNLVHNFPKPELDENVILETKKIIDSILNPSDEPTNDINYIKYENPNPNPNPNPNPNQEQQQQSSSSSSKIIQIKQFQEDPMLPPKFKLRKNRHERIIEDVTFVKDLKTKKLTKEDREFWNIPAAVSNWKNSQGFTIGLDKRMIGREHVPIEMNIEKFNDLSTALSDADLQAREDLKQRNEIRQQKQLQEKRLRDEKIKEIANRSKRRRY
The following text describes a protein:
Function:
Plays a role in the regulation of food intake and body weight and in reproduction. May also play a role as a central modulator of cardiovascular and renal function and nociception (By similarity); [Spexin-1]: Brain administration of the peptide inhibits food consumption. May function as a satiety factor for feeding control. Involved in the negative regulation of the reproductive axis by inhibiting luteinizing hormone secretion from pituitary cells.
Miscellaneous:
MISCELLANEOUS: Amidated and nonamidated form of Spexin-1 had similar effects on food intake/feeding behaviors.
Subcellular Localization:
Secreted. Secreted, extracellular space. Cytoplasmic vesicle, secretory vesicle.
Sequence:
MKDLRTLAAYALALLLLATFVSYSRSAPMGSFQRRNWTPQAMLYLKGTQGRRFVSEDRNEGDLYDTIRLESQSQNTENLSISKAAAFLLNVLQQARDEGEPY
The following text describes a protein:
Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDSAESPTKTQAGEDENYSLLCQAHEQFNNSEFDRCLELLQELETRGESSGPVLRHNRAVVSYYKTGCTQHSVLLKELEALTADADAPGDVSSGLSLKQGAAAATVARYNRAVIYYHRHMFGTALEKLAPLVARLEALEKAMAALVATLQLQLLLATNQLNRAEAFLDYLQYKLNLVATAPSSNAAEEAAVVGTAPPSAATNSSVVASPGGAAVEGAVPGLGGSLQLLQLITLVLNRKPVVIQEDGTPEYAALKAQQYYIMKDFQMAAKQLMRINNECTQAGTITPQLSTCIANNMGVIHLRVRHYAIAAKFFQNALNFDQQLARNLRQSTLQTMSSARSCEILYNLGVAMLHLRRPKEAFQCFLVPVKQFHSNPRLWLRMAEACIMEHEAKLVEEERQSQSETPSTKPYAPQSAGVPEPTLEFAVLCLRSALTLTQHYKTRFHMAAVSSEDVEAPEPKDPTQESWRHPQDNNFCNPSKPVSLESLENMMAAIYAAHSFVSLRLGDHVTALEMSEKLLACERLSDAHKLLGHMYAGEALMLMDKASEARDHLDPTFVGTLNAFDFETRDWQLKSVDAAQNVVRYNLAVAMALQNDLPQAKALLANLTHSLVANKALALRRFMDLKMGPVPGGTPS
The following text describes a protein:
Function:
Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation.
Subcellular Localization:
Cytoplasm. Note=Sequestred at the bacterial membrane by SdpC-bound SdpI.
Sequence:
MNNVFKAISDPTRRKILDLLKGGDMTAGDIAEHFNISKPSISHHLNILKQAEVISDHRKGQFIYYSLNTTVLQDSINWMLNFINKGDNDL