lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Membrane-localized H(+)-dependent K(+) and Na(+) transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MELISSSTIGNSALCLTLISILIFFFLTTTTIPTFPDHPLRSLLDDSQITTNSSSIVNPKSSCVSSRSHDNGGVINYFSLHYCIFNENLFFSIPILSLLILLHFYILIKTAQTHFSTVTTKLADRLNLSPSMAAVTLLALGNGAPDVFASVAALRGGQYRTGFGAILSAGTFVSAFVVGFVAIYAAPFPVDAASFVRDVLFYLIAALFLFYVYLSGEIFVWQAIGFVGFYIFFVGFVFWMDFGTNVEKGKSISEEEKDLLRLQDCEIAAGSLGSYKAEKEHQFSGIFRLYGTISRMWETPVSVLLNLTIPKPSPSEWSRFYRSANIVFCPFALLYTCNSFVQLNHPISFLFPNTHLPLWLVVLFMTSSLAFLHFTVEKQPPKTEQLPVIVVAFIMSVFWISTIAGELLNCLAALGTLLKLPPALLGLTVLAWGNSVGDLVADVAVAKAGRPAMAMAGCFAGPMFNMLVGLGSALVMQTANVYPDAYKLGFHVGIVIAFVFLLLSLMGSLLVITWSRFRVPRFWGICLVGLYVAFTFVSLIIASVST
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane.
Sequence:
MADDDSKGSAAEASCSPSSVDSSCQAAHTVDDRSQILAQATRFLTSANISESASEQDKREFLRTKGLTEDEITRAFNDAASPVARHDRHQTTTNQPWTGDMDPFDIAARQFDDPINADALVPPPKSYPNTPLALYYDPPTAHSAQPVRTTNHAQDASASPLTRYQVLLQFFRTLSYMMMLSGGLTAIVVSSYRAYILPKITAMFHARSIVLKHHIVLFDKLRSNVASLAMYAPIQHARISAEQNGTAANAGLPLKGVLKKVHFHDEVDAASEKEGVKSTQHGSGNEKVVMPSTDVVVDAKTPLLSEVEASEEGSTGKDEGAEAAFGKHESIDVMTPIRESMARLAEALKGGLSGRPTATVSNDARPPSATTTSSSRGARAATVTDADSGSDSWEDDSSDAASADDDDDGLEFDPYGAYQKKHKHTQSSSSSFTTASDGGSESASICDLKAALVSLNADISTHAFASSTSLSSGGGAFRFGPGTTDTNASGAESPKSGDLGQVKAEIRSLKGLLLSRRNFPSYAARPPPLPASAMGDARSGSAIV
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Domain:
The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.
Sequence:
MLVEKFLKDFTIPEKIEFLKSQGDGSYGKFTIYPFERGFGITIGNTLRRVLLSSIEGYAITAMRVQSNNKDSSSKVVSSEFDLIPGVSEDTLEIIANIKNIHLKLGEGEQRKTISFSVSGKDTNVLKASHFERDGVEVFNKDLVIATLSHDVNLDLEFQINYGRGYVSSEQNSKYLEEVNVIALDSIFSPIEKVSYSVEDTRVGQRSDYDKLVMEIWTTGVISAKDAIKKAASIVREFLFPLVDFEDNVNTSFEKSKSESSNLLDMSIEKLNLSVRSLNCLAKENVRTLGELISKNAEELSKARNFGKKSLEEIIEKLGSYRLYLGMSKEDALSVLSKNVKISE
The following text describes a protein:
Function:
Endoglucosidase that acts as a host immune evasion factor by mediating hydrolysis of the N-linked glycan from the Fc region of host immunoglobulin-gamma (IgG) during infection. Specifically catalyzes the hydrolysis of the beta-1,4 linkage between the first two N-acetylglucosamine residues of the complex-type N-linked glycan located on 'Asn-297' of the Fc region of IgG antibodies (IGHG1, IGHG2, IGHG3 or IGHG4), thereby preventing interaction between IgGs and Fc receptors and ability to activate the complement pathway (By similarity). Shows a specificity for biantennary complex type N-glycans; does neither cleave larger complex type glycans nor oligomannose and nor hybrid-type glycans. Specifically acts on IgGs; does not act on immunoglobulin alpha, beta, delta or mu.
Subcellular Localization:
Secreted. Host extracellular space. Note=Secretion is tightly regulated by carbohydrate composition in the growth medium.
Sequence:
MDKRLLVKRTLGCVCAATLMGAILATHHDSLISVKAEEKTVQTGKTDQQIGAKLVQEIREGKRGPLYAGYFRTWHDRASTGADGKQQHPENTMAEVPKEVDILFVFHDHTASDSPFWSELKDSYVHKLHQQGTALVQTIGVNELNGRTGLSKDYPDIPEGNKALAAAIVKTFVTDRGVDGLDIDIEHEFTNKRTPEEDARALNVFKEIAQLIGKNGSDKSKLLIMDTTLSVENNPIFKGIAEDLDYLLRQYYGSQGGEAEVDTINSDWNQYQNYIDASQFMIGFSFFEESAPKGNLWFDVNEYDPKNPERGKDIEGTRAKKYAEWQPSTGGLKAGIFSYAIDRDGVAHVGKEYSQRTYQELEAGLKKHPVVDNISHTDYTVSRKLKALMAEDKRYDVIDQKDIPDAALREQVIQQVGQYKGDLERYNKTLVLTVDKIHSLKGLEKLSHLQKLELCQLSNVKEVTPDILPESMKKDAELVMTGMTGLEKLNLRGLNRQTLDGIDVNGLTHLTSFDISHNSLDLSEKSADRKLLMTLMEQVSNHQKITVKNTAFENQKPKGYYPQTYDTKEGHYDVDNAEHDILTDFVFGTVTKRDTFIGDEEAFAMYKEGAIDGRQYVAKDYTYEAFRKDYQGYKVHLTASNLGESDTSKVTATTDETYLVDVFDGEKIVPHMTLHVGNGATIMENLAKGAKVIGTSGDISLAEKVVDGVVADSFWTWDTKNWIAFDLNSQVIAKEWRLFNGETDPRFKDKELNIQKGRLQILKDKTIHLENMSKDERDSYLADEQNWITVSEITSNQKIYNGSITDITSRYWRFCVDEGVSSKSPQYTELQILGQRLSSDIASTVQD
The following text describes a protein:
Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. HSF2 is expressed in a form that binds DNA constitutively but loses DNA binding by incubation at greater than 41 degrees C.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.
Sequence:
MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILPKYFKHNNMASFVRQLNMYGFRKVVHIESGIIKQERDGPVEFQHPYFKQGQDDLLENIKRKVSSSKPEENKIRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKHAQQQQVIRKIVQFIVTLVQNNQLVSLKRKRPLLLNTNGAPKKNLYQHIVKEPTDNHHHKVPHSRTEGLKSRERISDDIIIYDVTDDNVDEENIPVIPETNEDVVVDSSNQYPDIVIVEDDNEDEYAPVIQSGEQSEPAREPLRVGSAGSSSPLMSSAVQLNGSSSLTSEDPVTMMDSILNDNINLLGKVELLDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVDLFTSSVQMNPTDNIKYTKSENKGLEATKSSVVQHVSEEGRKSKSKPDKQLIQYTAFPLLAFLDGNSASAIEQGSTTASSEVVPSVDKPIEVDELLDSSLDPEPTQSKLVRLEPLTEAEASEATLFYLCELAPAPLDSDMPLLDS
The following text describes a protein:
Function:
Facilitates protein transport into the nucleus. Interacts with various nucleoporins and with Ran-GDP. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.
Subcellular Localization:
Cytoplasm. Nucleus envelope.
Sequence:
MDPDAVAKAFVEHYYTTFDSNRAGLVSLYQEGSMLSFEGQKIQGSQNIVAKLTSLPFQQRKHNITTVDCQPSGPANGMLVFVSGNLQLAGEQHALKFSQGTRSLIDLQLTRSFGTFVMHSVIDLLLDVPFGIESGKLLRVQRHIQVELCLRIVVAWIYEPLFQAKRD
The following text describes a protein:
Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription.
Subcellular Localization:
Nucleus.
Sequence:
MEDVVKVKVEEDGIPTAVLPMEGLHDVGPPPFLSKTYEMVEDSSTDQVISWSTTRNSFIVWDSHKFSTTLLPRFFKHSNFSSFIRQLNTYGFRKVDPDRWEFANGGFLGGQKHLLKTIKRRRNVGQSMNQQGSGACIEIGYYGMEEELERLKRDKNVLMTEIVKLRQQQQSTRNHIIAMGEKIETQERKQVQMMSFLAKIFSNPTFLQQYLDKHVHRKDKQRIEVGQKRRLTMTPSATGSDQPMNYSSSHQESEAELASIEMLFSAAMDNESSSNVRPDSVVTANGTDMEPVADDIWEELLSEDLISGDRAAEEVVVVEQPEFDVEVEDLVVKTPEWGEELQDLVDQLGFL
The following text describes a protein:
Function:
Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. May suppress bsk/JNK activation during the immune response.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Mainly found in the nucleus.
Sequence:
MEQSQSQRQAWPSSSAGGGKAQDSGVLTREDFDGGPVSIDEVDTGLFLGNLTAATHMETLRSFKITHILTLDSVPLPQHILEASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRRMGCKIDPNCQRYKIHRLRLAGEQMRKAKILPQSFHSVVRPDPDITRENPEPIVFRCRRCRRVLASKSHVLEHKPRDRPPQEVVPKEKEEVAAAKLPAQSHDQAENHHGARMLEQLSERIRQSSLGSPGHESTPNYCRSILFVEPIAWMHRIMLNTQGRLYCPKCEQKLGNFSWINACKCPCGETMTPAFYLIPSKVELSKAVQNVQTTV
The following text describes a protein:
Function:
Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
Subcellular Localization:
Apical cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Dynein axonemal particle.
Sequence:
MYIEALKPIPLRDIGSQAWLKQHEMLEKLNAQAHTNALMDTDEFVHEAFISLDKLAFLVYELVSLEMWRERVRPELEALGYAEQSTVAPYMIHYHEATVINLLEAVLYHREAVEALGDAAIDLIDYCQRACTYLLARTEEDFEREVEQENLSARDMDNMIQTLVALVVSPPWSQRHDGQLLKFTDEGKWVDVPHQNQFQLTKPEAQVWLALYNLLMEPECRRKYEYNSHSKAEILRLRGFMNEVLLDQIPVLVELRRALEELSLMEPPAPDTSIVLEQLPEIRQGLEKINGGRWAQLAAYQNKKVFNPDEQTRKAQAKLLAETYSLDMLDSLFPEQPKCVVCGADAVNRCSRCQSEWYCRRQCQVEHWPKHKAACNLMSAAAEGKE
The following text describes a protein:
Function:
As part of the MCIA complex, involved in the assembly of the mitochondrial complex I (Probable). Involved in the innate immune response; promotes the production of antibacterial peptides.
Subcellular Localization:
Cytoplasm. Nucleus. Mitochondrion.
Sequence:
MLRRAQCLLRLHGNGGHSLVSRFRNYATDEGNPKQNPNPNPRAQKPGTKNLPALRNPFAAAQDRTKNSYLTMVEIFQERDVHRRNHVEFIYAALKNMADFGVERDLEVYKALINVMPKGKFIPTNMFQAEFMHYPKQQQCIIDLLEQMEDCGVMPDHEMEAMLLNVFGRQGHPLRKYWRMMYWMPKFKNLSPWPLPDPVPDDTLEMAKLALERMCTVDLRSKITVFETSELKDAIDDTWIVSGMSPEQEKLLREHSRQKALYIEGPFHIWLRNRRINYFTLRADADSEFLSELDERQLDEDDVSHIEVPFFGRAPPRRHNQLGKLRSVHQQDDGTIMAICATGTSTKDSLLSWIRLLEANGNPSIGEVPVLFRFTSEVPAKAEEIEGGASVPATSDNSSQDEHISSRQK
The following text describes a protein:
Function:
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.
Subcellular Localization:
Nucleus.
Sequence:
MFHFLFGRRESKRKHRKSKQSSSMQSVEPSRPMFAMVCANNVNRSAAAHERLSAAGLRVCSYGAGRQVTFPGRTSTDARTFKFLTPYAVMHSTLQEEDAALFSGNGVLRILERDMPLKAAPERWQSIGNKQLLGIDVVVCLDYVMFLTVLEDIQMRIRLSFKTKQFHIICLDTADTPEEAVSGGERVLGLCRELDVPSDELTEEFVKTVVEKFEKKHELQMFYLGLHM
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MTELASSGGGSPAGDGEEGLGDERGLVIHHPAEEQPYRCLLCGQTFSQQPSLVRHQKAHAGSGRAAAFVCPECGKAFSVKHNLEVHQRTHTGERPFPCPECGRCFSLKQNLLTHQRIHSGEKPHQCAQCGRCFRESRFLLNHQRTHARMPAPHPRRPGVFGERRPYFCPRCGKSFAREGSLKTHQRSHGHGPEGQAAHLGRVL
The following text describes a protein:
Function:
Component of the circadian clock or downstream effector of clock function. Required for suppressing daytime sleep (siesta) under ambient environmental temperatures. Part of a heat avoidance mechanism that modulates daytime sleep behavior under different environmental temperatures to minimize the risk of heat exposure. Under cooler ambient temperatures, suppresses daytime sleep (siesta) and thus allows for longer periods of daytime activity.
Miscellaneous:
MISCELLANEOUS: Named 'daywake' based upon its function in daytime sleep suppression.
Sequence:
MQLTGASMFLVWVGLLSWVSCRVDASEGFPSPLKRCKLQDESCLLAQAQTFFQAFKNGIPERQVAALEPIALGTMFIESGGHSESIKFKLTMSDAKLYNLANSMMVKSLKGFTKDLTRPLKLTLLLDNPELEVRAKYDVDGKLLILPIVSKGDLTIRLNDVHTKVWITAEPVKRSDGHTYLNITDYKTATKIKGGHFDLSNLFNDNKELRDSTLKVLNQEWSTLALDVQPKINEACAKAFSAIVQSLWANIPYDEFFEKE
The following text describes a protein:
Function:
Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.
Subcellular Localization:
Nucleus.
Sequence:
MVKKKNSIPGRWKSLTAIGQRIPGSRFIAFKVPLKWQANQRVAPNQKFTPKDLLSEIRARNEDLGLIIDLTYTERYYTEKDLPRSVQYIKLCTAGQQIPEDGTIHQFKKIVRRFIWQNTSNDKLIGVHCTTGINRTGYLICRYLIDVDGWDPETAVNAFAQTRGHPLEGVVYTGDLLNGPTRSNLGIDQPPSVEETRGELKNQPEDRRPEKQSALRSTKPDFITDEYGDFDARKLPLPPPLPKERPRSTKLFEDDKDFLTTMPEYVERVRVARQTIERQKLEAIKISAVRERSIQDQSLVQPKQRIYNSVAEVTQEILRNRSMEAGRLVESQSRYGSEQRVEATLDRNQERFGNRTMDRIMPANSSQSLEFSQGMVGRHDNYSNAAPGPAPYSSHPMSLPNFNTEICKTDIGKTEAQSRFQYQHASEFSTKMAPLDRNDLLFGERPTPQLTSNIPTSLNELLQKEATMNHRQLLEMQSRSLQESPGLYLREREMTMGPLQGQRMDGMHPEEKQFLMNKARLMIDNERSAGTSNYEPRLYQERNIIPAADFRGANRFAPYQPPMRPQQSNDFLRNRDPGPPLHENRDHHGSLAYGYNYNMQRGGQPMDRFLLQDIEARNRLHLK
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MSQRGRLKRSSPPPVNVNKKFPSFEGRQTSIKDFFSSSPDDLNNNNNNNNNKIALLDNTNNNNNSNNNAVTPLKKTTTTVTTTEIFETIDNNINNSSISSSINNNNNNNLMSQFQQTQTPSKKTIKKVTTTTETFEEFVSTPISPAASSISQININSPPQTTPLINADKSPNSLKNSSPLTQLPQPISQPVPPSQSQTNTQLNKNNGQLIINNNSVRYYLKDFLVVTETVYNRDNHLFIDDEKFYIESMIQSIDREAQHLFVRIYNRKGPWFQTSLLGESYKDEFIDINKPIGTLVEYGFLDVYQSSKNDFKEIAQLLKVEQLKSIVGSIASRSLTSSSSTAKQTYLEMISGKPFKGQMTLTPSEPIYKKKVEDLVGYCVMIRPEVLELWRTIHHLYFYSWSAHDSKQIIINNIMGKAYPNYSVWKSKCKNKKPTNDEIIVSSQNDNIIDLTINQSSQSQSQSQSQSQSQSQSQSQSQSQSQSQSQSKSKSKYDIDLTNNESIFVTRQSLLDYEKAKKLEEKVIATNEIGDWDSMQKILQICLEELSRTVSKSVNYSFALKFTPGWVYTKILSWSITVLEKSRKYQECLDYLMLLIDSPFCRGKRGQWWQRMIINYKHLNRAQDALVIAERSLSDPYLRSGDRLAIEKQLVFLSVPPRRWKIPKNLLQFQNKLREPNSITLVREKVSNNQPGHKSKYLFLTPKINKTIIKNNNINNNITNHNNNNTNNNNNNNNNNNNNNNNNTNNNNENNEKDKQIDSDEEIIPSTQEQKEEDDNKEKKKKRSSRFFGSSQSIIIDAETTLEINSDDEIFPESYQSSDEKVDKDLEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKENKNNSNTDKSNEELDQVLIEKVLCGSVEEISLEHYALEEWQGIHCETSLFLSLFVLLFWDIIFDSNIPHVFQSPFQDAPLDYGTDEFYYQRKESIDKRIELLKNSELNYLYSLLDDAWLHNGCEARGVNWKQHTIDQLKTITKCLGGPLLAFVCKLLTEDYKNFSHGMPDLLLYKTTTNNNNNSNNNNNNNNNNNNNNPIDLDKDEQSQEEKEKEEIIDFIKFVEVKGPGDRLRDQQRVWIDLLISFGCDVELCYIKNK
The following text describes a protein:
Function:
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSGPQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYSML
The following text describes a protein:
Function:
Serine/threonine-protein kinase component of the sperm flagellar doublet microtubules. May act as a regulator of sperm motility by mediating phosphorylation of sperm doublet microtubule proteins. Plays a role in DNA condensation during postmeiotic chromatin remodeling and histone-to-protamine transition during spermatogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Nucleus.
Sequence:
MSGDKLLSELGYKLGKTIGEGSYSKVKVATSRKYKGVVAIKMVDRRRAPPDFVTKFLPRELSILRGVRHPHIVHVFEFIEVCDGQLYIVMEAGGADLLRVVQRSGPLACGRARDLFAQMAGAVRYLHDRHLVHRDLKCENVLLSPDERRVKLTDFGFGRQARGFPDLSTTYCGSAAYASPEVLLGIPYDPKKYDVWSLGVVLYVMVTGCMPFDDADVARLPRRQRRGVVYPQGLEPVGPCRALIAHLLQFCPADRPSAGQVVRNAWLRGDS
The following text describes a protein:
Function:
May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
Subcellular Localization:
Cytoplasm.
Sequence:
MGLGQGWGWEASCFACLIRSCCQVVTFTFPFGFQGISQSLENVSGYYADARLEVGSTQLRTAGSCSHSFKRSFLEKKRFTEEATKYFRERVSPVHLQILLTNNEAWKRFVTAAELPRDEADALYEALKKLRTYAAIEDEYVQQKDEQFREWFLKEFPQVKRKIQESIEKLRALANGIEEVHRGCTISNVVSSSTGAASGIMSLAGLVLAPFTAGTSLALTAAGVGLGAASAVTGITTSIVEHSYTSSAEAEASRLTATSIDRLKVFKEVMRDITPNLLSLLNNYYEATQTIGSEIRAIRQARARARLPVTTWRISAGSGGQAERTIAGTTRAVSRGARILSATTSGIFLALDVVNLVYESKHLHEGAKSASAEELRRQAQELEENLMELTQIYQRLNPCHTH
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
Subcellular Localization:
Mitochondrion membrane.
Sequence:
MAWFRPPPPHTQLRPWVPDAIFIPISRAVERVGVFFYNRVLNKTEVGLFDKRWNKNVHGPYCHWRYYGKLDTKFMDVKLGDLPAWMARREKTPSAFYNEFMRNIWRVHNLYYSGPVYNNTVKVIFRFIFAYSFLNWLVKSHRYVDFQKTMYHW
The following text describes a protein:
Function:
Beta toxin that show multiple effects. It enhances the open probability at more negative potentials of human Nav1.3/SCN3A and Nav1.6/SCN8A, of the insect channel BgNaV1 and of arachnid VdNaV1 channel. It promotes an important shift in slow inactivation processes as a function of the prepulse voltage in human Nav1.3/SCN3A and Nav1.6/SCN8A and a small shift in Nav1.1/SCN1A, Nav1.2/SCN2A and Nav1.4/SCN4A. Finally, it reduces the peak of sodium currents in Nav1.3/SCN3A (80% inhibition at 70 nM of toxin), Nav1.6/SCN8A (55.3%), Nav1.1/SCN1A (53.3%), Nav1.5/SCN5A (46.7%), Nav1.2/SCN2A (42.7%) and Nav1.4/SCN4A (20%) voltage-gated sodium channels. It has also been shown to affect the sodium current permeability of rat cerebellum granular cells in a partially reversible manner. In vivo, an intraperitoneal injection (20 ug) into mice produces excitability, respiratory problems, convulsions and death, within the first 30 minutes after injection.
Miscellaneous:
MISCELLANEOUS: Negative results: does not modify the function of the Shaker B potassium channels. Does not reduce the peak of sodium currents in Nav1.7/SCN9A, insect BgNav1 and arachnid VdNav1. It does not promote a shift in slow inactivation processes as a function of the prepulse voltage in human Nav1.5/SCN5A and Nav1.7/SCN9A, insect BgNav1 and arachnid VdNav1.
Subcellular Localization:
Secreted.
Domain:
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
Sequence:
MTRFVLFISCFFLIDMIVECKKEGYLVGNDGCKYGCITRPHQYCVHECELKKGTDGYCAYWLACYCYNMPDWVKTWSSATNKCKGK
The following text describes a protein:
Function:
Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSVCYRPPGNETLLSWKTSRATGTAFLLLAALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPLGQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAALLLAVPAAVYRHLWRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLRGARWGSGRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGGRSREGTMELRTTPQLKVVGQGRGNGDPGGGMEKDGPEWDL
The following text describes a protein:
Function:
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, growth cone. Cytoplasmic vesicle. Early endosome. Endoplasmic reticulum. Membrane, clathrin-coated pit. Nucleus. Perikaryon. Secreted.
Sequence:
MFCGKLNMHMNVQNGKWESDPSGTKSCIGTKEGILQYCQQVYPELQITNVVEANQPVTIQNWCKRGWKQCRSHPHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTAAKESCSEKGMNLHDYGMLLPCGIDKFRGVEFVCCPVADESDNVDSAEAEEDDSDVWWGGADADYVCIWTSSQDFLPLTKNPRFDAVWKCPNFLSEFTFYFESSTLKCYSGCIVFCFWSVPTTAASTPDAVDKYLETPGDENEHSHFQKAKERLEAKHRERMSQVMREWEEAEHQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRVALENYITALQAVPPKVIAKLTFFVEFIPPPPPPPEELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVDGEVSLDNFQPWHPFAVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNVKTEETSELKMDAEYRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
The following text describes a protein:
Function:
Glycosyltransferase involved in the biosynthesis of pectic type-II arabinogalactans.
Miscellaneous:
MISCELLANEOUS: Overexpression of PAGR positively affects the biosynthesis of type-II arabinogalactans.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MAELRHSSSLGSRSSSSPLRAAGDEDSSSPHVHDHSPNGGDDEDGRPRHPSRDRDRPIWFHSLFPFFGDDPRVSPQKNKISLLLILILAIASLISVYGIINHLNAPYLCKKDGIVLNCPHVKESPSPWENPLSATTSWKPCAERRIGGISDLPPENETNGYVFIHAEGGLNQQRIAICNAVAVAKIMNATLILPVLKQDQIWKDTTKFEDIFDVDHFIDYLKDDVRIVRDIPDWFTDKAELFSSIRRTVKNIPKYAAAQFYIDNVLPRIKEKKIMALKPFVDRLGYDNVPQEINRLRCRVNYHALKFLPEIEQMADSLVSRMRNRTGNPNPYMALHLRFEKGMVGLSFCDFVGTREEKVKMAEYRQKEWPRRFKNGSHLWQLALQKRKEGRCPLEPGEVAVILRAMGYPKETQIYVASGQVYGGQNRMAPLRNMFPNLVTKEDLAGKEELTTFRKHVTSLAALDFLVCLKSDVFVMTHGGNFAKLIIGARRYMGHRQKSIKPDKGLMSKSFGDPYMGWATFVEDVVVTHQTRTGLPEETFPNYDLWENPLTPCMCKA
The following text describes a protein:
Function:
Required for the assembly of the TOM (translocase of outer membrane) receptor complex, which is responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins.
Subcellular Localization:
Mitochondrion outer membrane.
Sequence:
MSAEEISNPLAESGVTISSDSEQYSAPESASPQSPSSSSPAVVLYQPPTVWSLFRSAVINLFLPFVNGMMLGFGELFAHEAAFRLGWSNTKVFPVSRRDARPIGPGVEVVERPRRRVDLDDHLDELTSLE
The following text describes a protein:
Function:
Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity).
Sequence:
MKTQLEGDRVLAGKEAVAELYKTGYFGRPREDGLELSLVEAAYLQFRGKIEIELEGRKLDFRALFEQASLRQPNFELKYIVYKDLKERGYYVQPSAADFRVYPRGSHPGKSAAKIFVHVLSERQPLPVKLLQDSVISAENVHKQFILAVVDEESDLTFYEIKTASPQGEMPEPYPEVKTDATFLEDRVIAWDAEASGALYAGGFYGKMLDPERLQLSLVESLYLFSRGIIVVRDRKDRIFSFDEFVEKASEIESSFLRKYGAYKALRDSGHVVKTGFKFGTHFRVYRKVESIEKIPHSEYLVNVIPSDYEFRLPVMSGAVRLANSVRKRMLFAVEKEEGVEYLDISRVKM
The following text describes a protein:
Function:
t-SNARE protein which regulates the secretion of aex-5 from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds.
Subcellular Localization:
Cell membrane.
Sequence:
MARKTIDSIPEPIALPTEETVQKRIKLKMVDLDAEIAKLNVQSLDSSIQMIRDIDQMNVDAVQTTAALEDQDEQLDKIEANLSNVIDDLNVVSHNITAMEHYCGCGFFRILRAPFKYFRKRERDIIKEEVLEKMTSPKLRRKEESNMMMFTNSSKRRESTGDFMKRLTCDAIEDELERNLMQIDQGLESVKNLAVDMHVQLKLQEPKLNRIEELTETNDFVVEGVNDKVKKLLH
The following text describes a protein:
Function:
Might be involved in the organization and polarity of the actin cytoskeleton. Interacts with the barbed end of actin filaments and nucleates actin-filament polymerization in vitro.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MAAMFNHPWPNLTLIYFFFIVVLPFQSLSQFDSPQNIETFFPISSLSPVPPPLLPPSSNPSPPSNNSSSSDKKTITKAVLITAASTLLVAGVFFFCLQRCIIARRRRDRVGPVRVENTLPPYPPPPMTSAAVTTTTLAREGFTRFGGVKGLILDENGLDVLYWRKLQSQRERSGSFRKQIVTGEEEDEKEVIYYKNKKKTEPVTEIPLLRGRSSTSHSVIHNEDHQPPPQVKQSEPTPPPPPPSIAVKQSAPTPSPPPPIKKGSSPSPPPPPPVKKVGALSSSASKPPPAPVRGASGGETSKQVKLKPLHWDKVNPDSDHSMVWDKIDRGSFSFDGDLMEALFGYVAVGKKSPEQGDEKNPKSTQIFILDPRKSQNTAIVLKSLGMTREELVESLIEGNDFVPDTLERLARIAPTKEEQSAILEFDGDTAKLADAETFLFHLLKSVPTAFTRLNAFLFRANYYPEMAHHSKCLQTLDLACKELRSRGLFVKLLEAILKAGNRMNAGTARGNAQAFNLTALLKLSDVKSVDGKTSLLNFVVEEVVRSEGKRCVMNRRSHSLTRSGSSNYNGGNSSLQVMSKEEQEKEYLKLGLPVVGGLSSEFSNVKKAACVDYETVVATCSALAVRAKDAKTVIGECEDGEGGRFVKTMMTFLDSVEEEVKIAKGEERKVMELVKRTTDYYQAGAVTKGKNPLHLFVIVRDFLAMVDKVCLDIMRNMQRRKVGSPISPSSQRNAVKFPVLPPNFMSDRAWSDSGGSDSDM
The following text describes a protein:
Function:
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
Sequence:
MAELESVSNLYSTIISRSAKTTKIEWMNSSKVLELPACRTLTFNKNGDFLAISDSQGVRIVSTEDYEKPLWQVAKPKTVEVKFSPLAKYLAIWEPVSKDKTTETVPCNLHVYNWRENKLVMEVVHRKQSDWSPQWTSNEFLCSRLANNSDILFYEDHNFSQVKCKLHMPKIMCYSLAASPASYHVVISVLGSKGEPSFVRLYKYPNFSSPSDALANKSFFKAERTELYWNNEGTSLLTLTFSDNSEESYYGEQHLHYISTKQESCQVHRAKPGPIYSIAWHPNSKEFCVVYGLMPAKATLYNLKCEPVFDFGTAPRNLAYFNPFGNLLCLAGFGNLNGGMEFWDVEKHKMLNKFSVVDTTYFEWCPDGVHFLAATLSPRLRVSNGLKIWHYSGIKLRSWETNELYSAIWKPVKEGTHTEPTLKFTASQAAVVSATATAKPAAYVPPALRNKMTSSTSGTPAATSAAVYKPKFREDYELPSNLKEQENKPMSKSAMKNKKKRDNKKAKKLGSSPEKADDDEEE