lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. Heterotrimer stimulates the Holliday junction resolvase Hjc.
Sequence:
MKVVYDDVRVLKDIIQALARLVDEAVLKFKQDSVELVALDRAHISLISVNLPREMFKEYDVNDEFKFGFNTQYLMKILKVAKRKEAIEIASESPDSVIINIIGSTNREFNVRNLEVSEQEIPEINLQFDISATISSDGFKSAISEVSTVTDNVVVEGHEDRILIKAEGESEVEVEFSKDTGGLQDLEFSKESKNSYSAEYLDDVLSLTKLSDYVKISFGNQKPLQLFFNMEGGGKVTYLLAPKV
The following text describes a protein:
Function:
O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MQPLARSLLGVPAVLALLTCSLDFAVAAEDVKKDDKNFQNLGKGETSSKNDLDLKEVVFVIQSQSNSFHAERAKQLEQNILKQAAELTQELPRVLLVHLLDKHEGAWTILPLLPHFSTTFGRNSSWIFFCEEETRIHIPKLLETLGRYDPSKEWFLGKALHDEQSTIIHHYAFAEDPTVFKFPDFAAGWALSLPLVNKLTKRLKSESLKSDFTIDLKHEIALYIWDKGSGPHLTLVPEFCTEDVSSPKAMGCATIFHTFLPLCGNPVKEMDVFVAVKTCKKFHDDRIPIVKQTWEEQASLIEYYSDYAEKSIPTIDLGVPNTERGHCGKTFAILERFLNHSSDSTAWLVIVDDDTLISISRLRNLLSCYDSKEPVFLGERYGYGLGTGGYSYITGGGGMVFSREAVRRLLASKCRCYSNDAPDDMVLGMCFSGLGIPVTHSPLFHQARPVDYPKDYLSHQVPISFHKHWNIDPIEVYFTWLAPSGKDATSGRKQFILGKIEQHVLQHILKQE
The following text describes a protein:
Function:
Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.
Sequence:
MEGQRYLDPARTRDVDAPERASDAFLPDLSSLTNSTSPCDARSGLAMVVLNFTLTPEAASKVHDLLACLSKFSDTVAIEAKRERFFTTYECIPSHGGPEGRFTCSMYTKSLLSVFKGRLYDPLGRDGAIDRCEVSVQERENEAQCRFIVKMVCNQGVIKTYKLTYEACEVMHALFDRNVAKNRWSLHSGAVKEYIEYFGTKTEMLDIYAGEDGRCVFKSYTEKVTNGKEILKHPLVTAVAVNTSDFDDFNVQPGLHIVVSVKDFKAIVVHADTLKTSLKAYYSQPTKPLQFSYGCDGLTCEFTLMTSGDYNAAPPTPTPAPQAPSRQTSRAPSTTTERADARRRPASQQVARQQDSESLFVNDEDEEWAPLDYDKEETLGWDASADHDASAFPTFRDSGSVSKTNNVDNAEIFEPTQRVSQLKGLGLW
The following text describes a protein:
Function:
Multidrug transporter acts as a determinant of resistance to acetic acid, flucytosine and clotrimazole, these 3 compounds acting synergistically against the pathogen. Reduces the intracellular accumulation of the antifungal agents flucytosine and, to a moderate extent, of clotrimazole. Its role in acetic acid resistance may be indirect, presumably through the transport of a still unidentified physiological substrate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Also localizes to membrane vesicles.
Sequence:
MVESGPHSINDDLSTNEYIEQPKFYHDDHASDSNSLSDIDDDNKKHGGLYGTVSRTTTRELPEDLESEISSTHSQDAKEDLEIQHNAAPYSLLNYRDKWCMVALLTACGFWSSLGSPIYYPALKQLEKQFDIDENMVNITVVVYLLFQGLAPTCSGGLADKFGRRPVLLIGMLIYVVASIGLACAPSYGVIVFLRCVQSIGISPSIAISSGVVGDFTVKSERGTFVGATSGFVLLGQAFGSLIGAALAAAWDWRAIFWFLTIGCGASFAICFALLPETKRSIVGNLSIRPKNPLNIAPVTLLPAARRKLKYDNPDYETLDKTKPVFDLTSAFKICALPEIFLSLLPPGLAFAMWTLMLSAISSELSAAPYNYKLTIIGVCYLPAGIGGLIGSFATGKIIDFQYKKKLKVFEEKKAAGIIPEDEKFNIMGARLQSVLPQNFLCVVTYILFGWSCDKGWKIPSILITSCVSSFCAMSTLSAMSTLLVDLYPGKSSTASSCFNFMRCSLSAILMGCFAKMKHSLTVGGTFTLLAGLVFVGNFLMFIPMKHGMRWREEREQRAALKAKSMDQANENGYKLFSKIKFSSPFKSEEKV
The following text describes a protein:
Function:
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Has a critical role in erythropoiesis. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasmic vesicle, secretory vesicle, acrosome. Cleavage furrow. Midbody, Midbody ring. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with RND2 in Golgi-derived proacrosomal vesicles and the acrosome (By similarity). During interphase, localized to the nucleus and cytoplasm along with microtubules, in anaphase, is redistributed to the central spindle and, in telophase and cytokinesis, to the midbody ring, also called Flemming body. Colocalizes with RHOA at the myosin contractile ring during cytokinesis. Colocalizes with ECT2 to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalizes with Cdc42 to spindle microtubules from prometaphase to telophase.
Domain:
The coiled coil region is indispensible for localization to the midbody during cytokinesis; The phorbol-ester/DAG-type zinc finger domain mediates interaction with membranes enriched in phosphatidylinositol 3,4,5-trisphosphate and is required during mitotic cytokinesis for normal attachment of the midbody to the cell membrane.
Sequence:
MDTMMLNVRNLFEQLVRRVEILSEGNEVQFIQLAKDFEDFRKKWQRTDHELGKYKDLLMKAETERSALDVKLKHARNQVDVEIKRRQRAEADCEKLERQIQLIREMLMCDTSGSIQLSEEQKSALAFLNRGQPSSSNAGNKRLSTIDESGSILSDISFDKTDESLDWDSSLVKTFKLKKREKRRSTSRQFVDGPPGPVKKTRSIGSAVDQGNESIVAKTTVTVPNDGGPIEAVSTIETVPYWTRSRRKTGTLQPWNSDSTLNSRQLEPRTETDSVGTPQSNGGMRLHDFVSKTVIKPESCVPCGKRIKFGKLSLKCRDCRVVSHPECRDRCPLPCIPTLIGTPVKIGEGMLADFVSQTSPMIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKTVPLLSKVDDIHAICSLLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGELPQANRDTLAFLMIHLQRVAQSPHTKMDVANLAKVFGPTIVAHAVPNPDPVTMLQDIKRQPKVVERLLSLPLEYWSQFMMVEQENIDPLHVIENSNAFSTPQTPDIKVSLLGPVTTPEHQLLKTPSSSSLSQRVRSTLTKNTPRFGSKSKSATNLGRQGNFFASPMLK
The following text describes a protein:
Function:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Sequence:
MEKGMELPVLLITQGVLFPEAKIKVPIRSKNNLAMLDRFVLNRSIASKTLILVAYRTESEKKVYDVGTVAMIEQVSCFTSSTFTQYTLHIVGVSRAKILDYALPVSRVKQIYSSGEVTEEKELKLYEVVQEFARSLSRDESTTLSNAMRHMIPERHVDEVVDLVASFIPRLPYEKQLEFLATVDVPTRVEAVVEWCAKHLESNPARPVRTSSPPKGITFHDLRENGKRRGRMIHNDNEEQQNPIERLAAKLEAANLPDDVRERIFEDLNRVKSSGGNGQESSMLLSYLEFVADLPWSTTTKDDVDIKKARQLLDDSHEGMENVKKRVLEYIAVRSLRDDGTGKAMAGPILCFAGPPGVGKTSVARAIAQSLGRKFERISLGGIRDEADIRGHRRTYVGAMPGRLLQAIRRSKTRNPVILLDEVDKLFAGVHGSPSAALLEVLDPEQNGAFMDHHNRKTIIQDFYNEKAEFTETREGHICPSSDIIFSLTNEDAEKVWVTGSFVGWSTLIEMRRDPRRPNEWRVRLTLPYGHHQFRFIVDGFWFIRDGIALECDDKGELCHYVHLPIDERRRHFERLHQSKKKAKWNMEKGEFIEAKFNFYEASRSSEEDSTELVFFTVFSLPTLALLIASHTFGSILQFLIASLRKHNGEQGVKRDPLTVVTLASSQFSLLWGLTLAVYYHAAGFRGNAVMRGGGTGTSFADLVIGLHSGSRKLITTASPFSNTELYALVGNRTHQLDIIQPNQQKDAATTDKSLVTMIEVNAIHAMSLVQRPCTINKITVPQKWPGLDRFYSNVVQNYQMSRTFTSRGSVEAVNQVLLRIFQQDMIEGFWTRRFLSTFKDIPAVDPGPPKKTNGYTPMSLSHLQLLFYFTGPGWILSIIVFILEINPLHSLIDSIMGFAHASKIPLIHKHPTTALRNGTLHLSYGAFNYPFFYKPSTGTKKPIGFLTDVWKYFTQDLEYHQYSYEHSSSVCCDGILLPVQEGLTLTTAGAYTATVARSKLFRKSAATYYTAFNFYEADRSAEEQSSELVFFTVFSLPALFLLIFAHILASFLHFLIKSTREINDGIGVKRKPLVDSFRFASQAFFSLGVTLTVFYHAAGFKGNTVMYSNPTQTSFTELVKGLHDGSRLLMTKSAKTFTGDQLYTLVGNRTTQSDVAEPDQTMLMQRLCENHKLVAMMEPNAVYSMSLVKKPCELNKISIPKPWKYLENFDVEIMQTYMMSWNYTKRGTGEAVNQVLLKLYPQDLIETFWTNRYLLSMRNKPSLKPPSTVLDDTFMPMSLVRLQVLFYFTAPGWLLYLNLPFDLSQVIFIATANDLSTIDGPLSDRLEIIEMSGYSTPEKIRIAEKHVIPSQLETHGVCPDYIRLPPEGLQHLVSGYTREAGVRQLARQIASLCRHAALSIAEAVNTNCEADCLPDFSLPIVYDREKIGDVLGPATFGDRSTDLVDRLRAGFRPGMVFGLAWTPYGGELMLIEGVAATTKSRDGKGRVIMTGKLGEVLKESVDVARSWINANAERLGVDSLLGKDVHVHLPAGAVGKDGPSAGCALVTSLFSLASRRLVRSDTALTGEISLTGLVLPDELELHFVRDLDEVLQKMMTPSSFVLSKFFALFSGSTAQFFAAQSPFFGRYYATAGRAILAPVAPMLAPPVLAAPAFAPPPLVAAAPAFAPPPVVAPAPAFVPPPPVVAAAPAPVLAAAPAFVPPVVAAAPLIRPAFAPPVVAPVPAFAPAPILAAPAPVAYAPAFAPFASPAYFIGSNKGKKADAAIDNSLHLAYAQWNYPYLFQQVKVIGFLAEIWKTFGYKIDYHQYPYESDSGSETCDGILQSIEDGSMITAAGASSPTLIRSKIFRMSLPVYYTSFQFFESSRADEEESTAFSFFAVFSVPALILLIASFATISTLNYATEKLQKLSTDNQVKTVTIVIYYHAAGFKGNNVMSIPPKTTSFTDVQNGLQTGKRKLITQSRTTIAAAKIAVLTRNRTTAPDIVEPDHNALLKKMCDDPILVTMLERYTVLGPTMVDRPCQFRRIPVPIDSQILNNFDRTVMQNFMFSKVYTDRRTVERINLVLLKFFDQDLIETFWTRRYSKTRKIFGDVPHSSAQIDETFRIMSLHRLVPLFYATAPGWLCSIVVFLFELISPFSNYFLVRLSVIRAK
The following text describes a protein:
Function:
Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MSVRLPSSMSYGEEEEPDVLQKMWDKSKQQPFVPLGSLLTAGAVLLAARSMKRGEKLKTQRYFRYRIGFQLATLVALVGGGFYYGTETSQHKQTREDKLREKAKQREKLWIEELERRDAIIQARKQRLEESKKELRELAKQGFIEEKESNDKKED
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLAYPMNSTAAQLNLTTACSQEIISNILLSKPCIAIDLDETLVFSYQLPPKTECFPVRIGRRRAYVTVRPGAIEFLDKIKEMYEIFIFTASEKPYADKVIDAIAPYIDQEHRLFRDSCQCADGYHVKDLRILNRPLNRVLLVDDMCASALFQRSNLVRITPWMGEKDDTVLLQQLLPVLTHISKEFDIASTAMQLLSTNVYPSLFTY
The following text describes a protein:
Function:
Minor structural protein that acts as an endoribonuclease during lytic infection. Degrades host mRNAs in the cytoplasm by cutting them at preferred sites, including some in regions of translation initiation. Together with inhibition of host splicing by ICP27, contributes to an overall decrease in host protein synthesis. Also, after the onset of viral transcription, accelerates the turnover of viral mRNA, thereby facilitating the sequential expression of different classes of viral genes. Binds translation initiation factors eIF4H, eIF4AI, and eIF4AII, thereby may interact directly with the translation initiation complex and thus digest specifically mRNAs. Also impedes antigen presentation by major histocompatibility complex class I and class II molecules, inhibits secretion of cytokines that would otherwise recruit lymphocytes and neutrophils cells to the site of infection and blocks the activation of dendritic cells. Plays a role in the inhibition of interferon-beta activation by the cGAS/STING pathway. Mechanistically, down-regulates the expression of host cGAS/MB21D1. Also decreases the accumulation of other interferon-induced mRNAs such as host IFIT3 or CH25H to subvert their antiviral activity.
Miscellaneous:
MISCELLANEOUS: Strain 17 is relatively weak regarding early shutoff compared to strain KOS. Strain HSZP protein is non-functional for host protein shutoff.
Subcellular Localization:
Virion.
Sequence:
MGLFGMMKFAHTHHLVKRRGLGAPAGYFTPIAVDLWNVMYTLVVKYQRRYPSYDREAITLHCLCRLLKVFTQKSLFPIFVTDRGVNCMEPVVFGAKAILARTTAQCRTDEEASDVDASPPPSPITDSRPSSAFSNMRRRGTSLASGTRGTAGSGAALPSAAPSKPALRLAHLFCIRVLRALGYAYINSGQLEADDACANLYHTNTVAYVYTTDTDLLLMGCDIVLDISACYIPTINCRDILKYFKMSYPQFLALFVRCHTDLHPNNTYASVEDVLRECHWTPPSRSQTRRAIRREHTSSRSTETRPPLPPAAGGTETRVSWTEILTQQIAGGYEDDEDLPLDPRDVTGGHPGPRSSSSEILTPPELVQVPNAQLLEEHRSYVANPRRHVIHDAPESLDWLPDPMTITELVEHRYIKYVISLIGPKERGPWTLLKRLPIYQDIRDENLARSIVTRHITAPDIADRFLEQLRTQAPPPAFYKDVLAKFWDE
The following text describes a protein:
Function:
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsilon-amino group of a Lys-170 at the active site.
Sequence:
MKTVTVRDLVVGEGAPKIIVSLMGKTITDVKSEALAYREADFDILEWRVDHFANVTTAESVLEAAGAIREIITDKPLLFTFRSAKEGGEQALTTGQYIDLNRAAVDSGLVDMIDLELFTGDDEVKATVGYAHQHNVAVIMSNHDFHKTPAAEEIVQRLRKMQELGADIPKIAVMPQTKADVLTLLTATVEMQERYADRPIITMSMSKTGVISRLAGEVFGSAATFGAVKKASAPGQISVADLRTVLTILHQA
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLVRYEVRCEHSLANPDLYRTVDRYDSEGLLEGMAIGGLVGLVRQLGDLAEFAAEIFHGLHVDVMTIVSRGKDLKARVARLEADLPAVEKALLSEASQCRFAYTARSKCRLSLPMDQNLCAQGELPPFVRGFYDDCRGPPRLFLLDKFDKAGRGACVKRYTDPTYFRITWATAQLERAEQAERERLAEQERRNSENNPSKKAGPLTYRRERVPSVQLEDLEGFIRDSDPDPRSEHLHRVVRISFEDDLTPDRPRPPEEPESLDATFRNRQVTEMNEGPVLDPVKITGKDIENEKLRRRTRVEYDADGEPSDEEEEEEEEEEAKCFMDTLTTMSFDADSEADFRSPRNARGSVDSRTSVDSETSSQTRLALVPQWVTPLKVLVLKAHEEGRRHTSPSRRSVGVNQKGDFTPLLRLEKPDVPIAGPEPGQESEASGGSSGSQPAIDHQQEARYADKLIENELNITSHNELETQESYVKLTEAQLKDSSKLSMITQRAAEKFANESHDSISLQDVFRALTRAKVEEQVLPAEARDQSPMPENEVSHVSRQDNQSILENAQQDVCVPKSRRLWARNNDSQVATSGILLRVLPLKLNGGVYNDDKLRARLLNDGEHSQEEIISPRALVQLEGEEVLKQDSEISSRIDCEMACNSSSNASSPYTNISSSSVVEDDGCTSSASESSPKGPNFFALLSPPESPSRNSRGLMGSHASYNTSSQFGRDSPKAPPTIPFLSLSPTVSRFSSFSYEPPVSFVDYSRPPPQLVSPPLEDINLSLHTSDGPAASSSQAPDKLKDVSTSNPSLNGVVAGLQAEANRSQPSRQPNSVVRPRTWNDRSEHNVAATLRAIRQERIFLVN
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins.
Sequence:
MVTVPIKTCIRTLSTTSRMDKSFAKWYRSLWQPKSNDEPPYDHIVQLGDPVLRVPANAIPEKELQSAEVQYLARHLTKVMRAYRCVGLAAPQLGLSLRAFVMEFKDELRDQYTKADYKLREMEPLPLTILLNPELKVLNYEKVIHTEACESVRGYRADVPRYREILLQGFDATGNRQELRLSGWNARIAQHEMDHLNGIVYTDIMNRKSLTCTCWQAVNAKSGRIQLSFASK
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSGHEMMHIKPSRWSWNRFKDLLNFYVMLGVIPATVVITYINLFIGPAKLAEIPEGYVPEVHEYYAHPITRWMTKHVKKSYQQEYEVMCQHIYETDYARKLRLAEKRVHQKMQEKQDSQAYYYEPVTGRNERHIKSMLERSVENVGTR
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MGFQVLRSVIQAPLAKRSFLCKSCPSGLRVLYNNILLSSRSYSTKGSAFTLIKKLRQETNAPIFLIKEAVEETNGQSFFEAKSVLSEKMKARGQRLAQQLQGRVAKQGWICTAILPDAQAACMLELNCESDFVAQNPKIQRLALSSASSILHSLNRVNADSTEQRNVSTDLDSLKKIILHSDKDSSSNLGNTLFDAFSNATSTTGERIELSRAIVFQRTKPQHQLGRYTHGTDVRVHSSLGRVGCLVSLSNAQKAGLADDIAREFVAQDPESIDDFLHNTSVYDNSKTMKDLLGSANVVDWVRWERGQAQ
The following text describes a protein:
Function:
Transcriptional repressor which maintains cell fate asymmetry of AWC neurons in adults by repressing the expression of multiple AWC (OFF) genes, including srsx-3 in the AWC (ON) neuron.
Subcellular Localization:
Nucleus.
Sequence:
MLFTIEQLELIKKLQHTGMSSDQLLKAFGELEVPEQLQNNNTIAAALYSPLLVQHLTTPKSETPVKLTVQTVPTPVKSEPQSSNCSSPFEHPICSNAPRPIRSQRTPMKEITTLDDPNELEEFMKQGEEACILDMKTFITQYSLRQTTVAMMTGVSQPYISKLLNGNHRELSLRCRKNIYCWYLNCRRHPNKLAAFLADPTTRLETNGDGELIPQRRERYVFRPILIRMLESFFTQTPFPDLPRRVEIANACNHVLKMDKKGVGLMPKEVVSPQVVSNWFANKRKELRRRSAEASAASTSSASSSASSTANHDSVSVSSMSPRDEETSSRNTTPETAISPSPAVSTFEVSRPSAIISATSSTTSPISIPATIIPSVSPSALELFAMAQQLGVQLPVPFPTLPTHFFPFQMAPFYGNPASILKSE
The following text describes a protein:
Function:
Can transport glucose, mannose, 2-deoxyglucose and methyl alpha-glucoside, but not galactose.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLRGTYLFGYAFFFTVGIIHISTGSLTPFLLEAFNKTTDDISVIIFFQFTGFLSGVLIAPLMIKKYSHFRTLTLALTIMLVALSIFFLTKDWYYIIVMAFLLGYGAGTLETTVGSFVIANFESNAEKMSKLEVLFGLGALSFPLLINSFIDINNWFLPYYCIFTFLFVLFVGWLIFLSKNREYAKNANQQVTFPDGGAFQYFIGDRKKSKQLGFFVFFAFLYAGIETNFANFLPSIMINQDNEQISLISVSFFWVGIIIGRILIGFVSRRLDFSKYLLFSCSCLIVLLIAFSYISNPILQLSGTFLIGLSIAGIFPIALTLASIIIQKYVDEVTSLFIASASFGGAIISFLIGWSLNQDTILLTMGIFTTMAVILVGISVKIRRTKTEDPISLENKASKTQ
The following text describes a protein:
Function:
Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.
Subcellular Localization:
Lysosome membrane; Single-pass type I membrane protein; Lumenal side.
Sequence:
MTCSNLKHHVKEKMAASRQARRLYTCLSRFSCALFVFASLAVGKESFSRQVSMHYNPGCNITECQSSPSNDNDTHNNLVHILARGSRDSIHYVWSTIGAPTVLMVHTTSKESELKVDWEKLLTTNGDNSGAITFEPSNEVDFSMAVMFNKIWEYEDLHDKSELPEDDTEMFEPYDLSQMRWGDFNLTMNTTGLTGNFTGATTQSDMESLFQNGSISFRIHAFKTDDRSADLPHLQYTSNQTQFDFTIDSVEPRGNMSRYAMELMLLTEDKHLDLKKMKSIDDEYTPGVFELFELTMTHSDQTDSYVQWKPVCYTKSTRSMAVATPTKTYKLKDLDTTSIPADTIARAYFTNLDRLQRKALNVSFGLTGDGSYVASNFTSWTASVGYGEPPSERLSLLIIIVISTGLGIPVVIIMFGGLFICCRQKDGDKGKKEIMDEYPTVNGGETDAIN
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Subcellular Localization:
Cytoplasm.
Sequence:
MYGRSWKLDINESEKIKSYLIKMGGVEESIKNSYELWRIKLGGSTFIYYTSGKLYSTPSAKVINIWDEIDKLVSKSYDLNKDYVLGFDEVGKGEVFGPIITCGVLIRKDVISQIPSELKTPDTKKSHGFEYWTRILKVLEDLISDGFYYIIDIIQPREIDRFNINQLLDLSYMKLIKQLITDLPYRKEVRIVIDDYGVGEGLQRFLEIIKGENNFETIIVTESEDKFLEAKLASLIAKSYRESILKNLQERYEIPESLIKGNMSNKALESFLKNYSKDDLWFIRRSFGKRIKKEKPSFYNLISEDNFRCFFCGKESSKVILKDYRFLCSFCGKEIKDLELAMKYHSGIIKLEKESFYSFFEIIKNSYLFDGFSFLVDNSLRNLLTPYEDIGRILILKRAFSKFLTLKIEGDSIAFSFFRNIYNV
The following text describes a protein:
Function:
Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Sequence:
MAAALSLMAATATRGVAARGVRAAMARGVEARVQMLRHPLGKGPAGCRRWAAQSAATPTTTSDNGKEAAATEPQPNWADRIVQSMGWLGGFYTKKQVQMRNAKELYSICAERSLHPHFYRVCDLPDTFQSWYLITQLHLYFFLVWLKQAGGDGPFVYKQMVTLFWEDVDHRMRIMGVDDRTIQQESLRELFSMFYGLIFAYDEGVAGDDMTLAAALWRNMFHDARADVDGQKLAVMVEYVRREMLRLDQTDVAKLIESGEHESTHSNQEHSIEPSTFFVVCETSPDSRLKTDLVNGTLSCKLLPHTHTHPSIHSNLSPHLSNNSYTTSSINNSRRSNDVNNNNNNSVLLSHTHRTHTHTHTHTHIHTHTHTHTIWYGFSNGRIDVAHEAEATPTTPPRSHSRSSVSSLASEASQPGSPSRRWRWLNFMRPDQSPLHMGGADTRSPHSTYKTLRSLQLDGPISCILPLPLTEAVWIGGHGGFLKVFDARTLECTADLTMHEDHIASLQVDDMNPDWVWTASRDAHVVLWNAQQQYALQNVILQTLLDDSALVADMVPMDDLLWLAVGTHVIGLTKRDARVIDAILPQFQKNRTSTSGHLSDGRIVRADSLSSSRSFLTRRRAENVAGDIVHAALEIGIQSVRLASSTTTPTVSSIPIPGLRSAEGLSASPASTLGRSPRPNPFGATTVPGRLDSTAGSAAESAASSNVSSDAEDDGMPHLPIPSVPLTALGQIFAAAADDGVSSNRFKRPRRHPILALPVDLICAGLDGELWCCSPKSSAMQVFDTRRSRRLLTWLVKCQGLTCVKRHDDVVWAGGTSGAIYAWHARTKHPLLRLCLHTDGVVGLAISPDARHLATASAPLDGSIIVHNMAELMRRYKHDTVISARLTSGDFEEFPRVHEGQHVQHVAAAQAETVGAYAVQPQLQADYDQYGFMRFAVVADVPPRSETRPLESRAIRAFRVDAEKVTANDLERHDEYASCLDPTDFGIASYLVFGSTGVLMEFWCHVWKHFVAARTAGIRRINGNNFYKKLVEHKSTKQLEYAELIKVNLSVVLDLLRTFSNNVFFQDFNAPSVVALQRVLTAFAFFIPRIGYTQGFNRLVAFAMLYLNEEWAFYALDAIVEKIMRFEYYNFPMTGCAVDRSMFVAMVKETMPELHDHFQHYCLDLQRICFSWFFTAFVNTLPTEVVLRIWDAFLCEGRSVLFRYGLALLKLHKDDILQFREDTELNAFFKEDLFRVRNTAFHDLGLDVEAFIATNSDYFRRVCEEEEQRLSGHG
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MSSSAVRWVPKPRREEPTATSSASETSNPTPDPVGPVQESRIAVGSDREHQRDESGDPSAMGATDDLKYLEAAIGRLDELRISGEEPELSEEQIRVNDQMQEDEVLALEAIYGDNVLSFDKKEGLRFFQVRMEYDLPDCINVSAMLQSSTTKVKSGSRSLNGRTKSDDSHEFLYTFNVQYLPPLLLTCLLPKSYPSHRPPYFTITVDWLNSEKISSLCHKLDAIWMEQPGQEITYQWVDWLQNYSLSYLGFDSGVMLDRYDMQDVKDIRADFGNARPDFIISSMINYDQEKCHQSFLNNLHQCIICFTEYAGTSFIKLPCQHFFCWKCLETYSNMHVMEGTVTKLLCPTDRCGGFVPPGLLKRLLGSEAYKRWESLVLQKTLDSMTDVAYCPRCETACLEDEEHHAQCSKCFFSFCSLCRERRHVGVECMTLEVKLQILQARQNSSNLSRNQLHMEREMINEILSVKEALRDAKQCPSCKMAISRTEGCNKMVCQNCGQYFCYRCNKAIDGYDHFREGCELFPREEIERWEIQMNPRQVVGQIRAELYPNVGHPCPTCRQVNPKVGNNNHIFCWACQKHYCAMCRKTVRKSSEHFGPNRCKQHTLDP
The following text describes a protein:
Function:
Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes (By similarity).
Miscellaneous:
MISCELLANEOUS: The N-terminal half is dispensable for proper Golgi targeting, whereas the GoLD region is required.
Subcellular Localization:
Cell membrane; Lipid-anchor. Cytoplasm. Golgi apparatus, Golgi stack. Note=Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae.
Domain:
Microtubule association is inhibited by the ANK repeats and the Golgi localization region (GoLD).
Sequence:
MTKTDPAPMAPPPRGEEEEEEEEDEPVPEAPSPTQERRQKPVVHPSAPAPLPKDYAFTFFDPNDPACQEILFDPQTTIPELFAIVRQWVPQVQHKIDVIGNEILRRGCHVNDRDGLTDMTLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPDPMDMSLDKAEAALVAKELRTLLEEAVPLSCALPKVTLPNYDNVPGNLMLSALGLRLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLFASVSKISKAVDAPPSSVTSTPRTPRMDFSRVTGKGRREHKGKKKTPSSPSLGSLQQRDRAKAEVGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAPASRIQRIGGSTDSPGDSVGAKKVHQVTMTQPKRTFTTVRTPKDIASENSISRLLFCCWFPWMLRAEMQS
The following text describes a protein:
Function:
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
Subcellular Localization:
Secreted.
Sequence:
MINSFKKLIILISLVIILLSSNNIFIDSFKIPVNQKNVKSSGDSSYQIGAGIYDITGASAEVNLMGYANPLQVGAGIHFRQRARAFVFVDSNGNRAVYVSTDSCMIFQEVKIHVVELLQDIFGPNVYTEANVLLSGTHTHSGPAGFSQYALYGITSLGFYKKNFDTICNGIVQAIVKAHKSVQPANMFTETGELWNTNINRSPFAYDNNPEEEKAMYDSNVDKNMTVLRIEDMNGNPFAAISFFAVHCTSMNNTNHLISGDNKGYASYLWEKQVNGPGTAGKGPFVAAFGQSNEGDVSPNTRGPTCRDGSPCDYKTSTCNGRNEECWSLGPGKDGDMFESTQIIGGNQFNKALELFNNASIQVSGPVQYRHSWVQFTNVSVEPPYNSGVDNATTCRGAMGYSFAAGTTDGPGAFNFVQSDNNTSGNPFWNFIGDFIAKPTPDQIRCQSPKPILLDVGMVEPIPWVPDVMPIQIVTIGQIVLVAVPGEFTTMSGRRLRNSVREIIGESIENPIVLIAGLSNTYSGYIATFEEYQVQRYEGASTVFGPHTLGSYMQEFGKLAQSIVDGTTVPAGPTPRNLTGHTLFFLPPVIVDAAPDFDDFGEVSIDVNLNYSVNETVSCVFYGGNPRNDFMIESSFLSVDLLTGTDQWTTVLDDGDWDTKFKWKMHDLGFSLITIEWVIAPDTTPGTYRITHSGFAKKNPFSSNLTPYQGISRNFVVQ
The following text describes a protein:
Function:
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Sequence:
MTQRFDVILRGGTVVNQDGEGLRDIGIASGRIAEIGALSQASAAEVIDCKGLHILPGVMDTQVHFREPGLDQKEDLETGSRSAVMGGVTAVFEMPNTSPLTVTEASFTDKVKRARHRMHCDFAFFIGGTRENVQDLPVLERAPGCAGVKVFIGSSTGALLVEDDESLRRIFQVIRRRAAFHAEDEYRLNERKPLRIEGDPRSHPVWRDETAALMATQRLVKLAHETGKRIHVLHISTKEEIEFLRDHKDVASCEATPHHLTLVAPECYERLGTLAQMNPPVRGADHRAGIWRGIEQGIIDVLGSDHAPHTLEEKQKTYPASPSGMTGVQTLVPLMLDHVNAGRLSLARFVDLTSAGPARLYNMACKGRIAAGYDADFTVVDLKRSETITNKWVASKAGWTPYDGVRVTGWPVGTFIRGRRVMWQGELVTPSQGEPVRFLETLKA