lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDEMEDFFENDELDREPSPMGDEAIEDNSGEGGTRRVVEPKLLRTKRLANPRLALNERILTGPKGISALRETLKDFKPNPKDDPYANLEKLMKKYAYWGHLMFPKMKTEDVLNRVETLGTRRQVKVFMIKHRLGETGEDSEHEEQENQKNGIIDDGASDNDDDLFKDLPEKEVTTEKAKNSEKSDQKTAEIDENVEEEYRMMEEERLREEQEAKEAADEDALMEDFGDMNNDW
The following text describes a protein:
Function:
Transcription factor required for yeast cell adherence to silicone substrate.
Subcellular Localization:
Nucleus.
Sequence:
MSLPMSPVSPINTTTSTSTTTTPLSPPSSIENSSHPLSTSISNNSITSDSSLDSNTSTSSTTTTNYGTKTPSGNARIFNCTLCQRAFTREEHLTRHTLSTHNKLKPFTCGICSRPFSRRDLLLRHAKNLHQGSEVAVSRIRKSYKHCNKDNDSKSGSDSNTNKTNKNGKKQEQEDDEEEGSRSDSSSGADDEDSNTSSGGSNYHAIGSGNKRFVNNSPQLKKILTNGSVPSTTTTSTTTVPTSTNNDTASITNSSTSHIHQRSLNVEDYDTPEKKRLKMSVNMLVS
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MNRIRIHVLPTNRGRITPVPRSQEPLSCSFTHRPCSQPRLEGQEFCIKHILEDKNAPFKQCSYISTKNGKRCPCAAPKPEKKDGVSFCAEHARRNALALHAQMKKTNPGPVGETLLCQLSSYAKTELGSQTPESSRSEASRILDEDSWSDGEQEPITVDQTWRGDPDSEADSIDSDQEDPLKHAGVYTAEEVALIMREKLIRLQSLYIDQFKRLQHLLKEKKRRYLHNRKVEHEALGSSLLTGPEGLLAKERENLKRLKCLRRYRQRYGVEALLHRQLKERRMLATDGAAQQAHTTRSSQRCLAFVDDVRCSNQSLPMTRHCLTHICQDTNQVLFKCCQGSEEVPCNKPVPISLSEDPCCPLHFQLPPQMYKPEQVLSVPDDLEAGPMDLYLSAAELQPTESLPLEFSDDLDVVGDSMQCPPSPLLFDPSLTLEDHSVKEIAEGSVDVLGQMQMAGDGCRSQGFRNSEKAASLPQSGVATANGKLESTSVS
The following text describes a protein:
Function:
RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation. Shows a preference for uridine-rich RNAs. Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA. Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1. Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
Subcellular Localization:
Cytolytic granule. Cytoplasm, Stress granule. Nucleus.
Sequence:
MAVRMCSSGFPDSPVSAIFCLFPEKEIHQTQVIQHQNTKGLHSDNTSIYPNMEDDSHPKTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSRRVNSSVGFSVLQHTSNDPYCFVEFYEHRDAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKAAFAPFGKISDARVVKDMTTGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKNVQESSSKQLRFEDVVNQSSPQNCTVYCGGIQSGLTEQLMRQTFSPFGQIMEIRVFPEKGYSFIRFSSHESAAHAIVSVNGTTIEGHIVKCYWGKESPDMAKGFQQMEYGQWGQWSQMYGNPQQYGQYMANGWQVPSYGMYGQAWNQQGFGVEDSLLAAAAQNISRQSQSPAWMGGFGAQPTQGQGAPVIPNQAGFGMAGYQTQ
The following text describes a protein:
Function:
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Localization:
Nucleus.
Domain:
The F-box is necessary for the interaction with ASK proteins.
Sequence:
MEEDGSDWGGLAPEILINIISRLTIQELWTGPMFVQKSWLTVCRDPYLWSIFDLEPWFDSYPESTHLWSPEFEQKVDLMLRSVVDWSEGGLTKIRVRHCSDHALSYAADRCPNLQVLAIRSSPNVTDASMTKIAFRCRSLKELDISYCHEISHDTLVMIGRNCPNLRILKRNLMDWSSRHIGSVPTEYLDACPQDGDTEADAIGKHMINLEHLEIQFSRLSVKGLASICEGCPKLEYLDLFGCVHLSSRDITSNVSRLKWLKEVKKPDVYVPRSGDVAQTERYGHWRLYDERFDIQAMRI
The following text describes a protein:
Function:
Binds histone H3 but seems to have lost demethylase activity probably due to its inability to bind iron Fe(2+). Possesses E3 ubiquitin ligase activity and targets directly CMT3 for proteasomal degradation to initiate destabilization of the heterochromatic state (e.g. CHG cytosine methylation and H3K9me2) of endogenous silenced loci. Required for the removal of repressive H3K9me2 histone marks to facilitate the transcription of AtSN1, AtMu1c, solo LTR and SDC, thus counteracting their transcriptional silencing. Mainly required to promote the basal level transcription of silenced loci such as TE and repeats targeted by RNA-dependent DNA methylation (RdDM) for silencing, a specialized branch of the RNA interference (RNAi) pathway. Also cooperates with RNAi pathways for gene silencing both by contributing to the production of 24-nt siRNA to initiate RdDM and by recruiting RDR2 to enable local transcripts to make dsRNA. Antagonizes histone H3K9 demethylase IBM1/JMJ25 function.
Miscellaneous:
MISCELLANEOUS: Misses iron Fe(2+)-binding sites required for demethylase activity.
Subcellular Localization:
Nucleus.
Domain:
The RING-type domain is necessary for E3 ubiquitin ligase activity; The JmjC domain is involved in histone H3 binding.
Sequence:
MQVNFDETCDSVIRMNANEQTRSANGIGNGNGESIPGIPDDLRCKRSDGKQWRCTAMSMADKTVCEKHYIQAKKRAANSAFRANQKKAKRRSSLGETDTYSEGKMDDFELPVTSIDHYNNGLASASKSNGRLEKRHNKSLMRYSPETPMMRSFSPRVAVDLNDDLGRDVVMFEEGYRSYRTPPSVAVMDPTRNRSHQSTSPMEYSAASTDVSAESLGEICHQCQRKDRERIISCLKCNQRAFCHNCLSARYSEISLEEVEKVCPACRGLCDCKSCLRSDNTIKVRIREIPVLDKLQYLYRLLSAVLPVIKQIHLEQCMEVELEKRLREVEIDLVRARLKADEQMCCNVCRIPVVDYYRHCPNCSYDLCLRCCQDLREESSVTISGTNQNVQDRKGAPKLKLNFSYKFPEWEANGDGSIPCPPKEYGGCGSHSLNLARIFKMNWVAKLVKNAEEIVSGCKLSDLLNPDMCDSRFCKFAEREESGDNYVYSPSLETIKTDGVAKFEQQWAEGRLVTVKMVLDDSSCSRWDPETIWRDIDELSDEKLREHDPFLKAINCLDGLEVDVRLGEFTRAYKDGKNQETGLPLLWKLKDWPSPSASEEFIFYQRPEFIRSFPFLEYIHPRLGLLNVAAKLPHYSLQNDSGPKIYVSCGTYQEISAGDSLTGIHYNMRDMVYLLVHTSEETTFERVRKTKPVPEEPDQKMSENESLLSPEQKLRDGELHDLSLGEASMEKNEPELALTVNPENLTENGDNMESSCTSSCAGGAQWDVFRRQDVPKLSGYLQRTFQKPDNIQTDFVSRPLYEGLFLNEHHKRQLRDEFGVEPWTFEQHRGEAIFIPAGCPFQITNLQSNIQVALDFLCPESVGESARLAEEIRCLPNDHEAKLQILEIGKISLYAASSAIKEVQKLVLDPKFGAELGFEDSNLTKAVSHNLDEATKRPQQNSCT
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
Subcellular Localization:
Nucleus.
Sequence:
MCGRRSACLPENIKKLRAEANKDLRDKYDEEDDFGGLANRKRRPETRDSESDEEPSVPAKRPFVNEKSTKGMSIGEKLLAKHGYQEGKGLGKHGQGIVEPIKESNQRGRAGLGHDTGKVLARDNSEFWDESAEEKTVKETVEWIEADPDTIDQVMRLNDGEGDGGWMVVGARKETIDDETTYVDAQQLKEMLESKSVFDSLTQRELNEARTRANPYETIGSAFFQNRAAMKTANMDAVFDFIFSQESNIAAMKAKNPMDLGVEPVNVDRTVEIFYFADVCAGPGGFSEYVLWRKKFYNAKGFGFTLIGNNDFKLQNFRATSANYFEAFYGTAQDGDVTNPANIDSFEEHIKKGTGGKGVHLMMADGGFCVDGKENIQDVHLMMADGGFCVDGKVNIQDVHLMMADGGFCVDGKENIQDVHLMMADGGFCVDGKENIQEILSKRIYLCQLLVSLCIVREGGNFFCKLFDVFTPFSASFICGSDETMKKRVGLCYLMYACYEKISIHKPHTSRPANSERYIICKGLRADTANVVKNYLKKVNLRLEELETQRQHEVGKEREMAKSRKYDNGAQKKKPVAEEQKYDVNEVVPYEVMARDDAFMEYIVKSNNKLVVRQKVYLDKYKSFAKNLNQIDRDQGKLREECMAYWMIPNIQKDKNRRPEINVNDTLAKFTARRKKPLFFSDQDWSQRTPHLDSKTHMNLNNQLYQHEEFECTFLGEKEPFLLISTGDHVFKRNFQSRDWERLPEPKYFRLPPDTILLVDLTKSYGFNAQKVLDKNDVRDVIRILDCAVLHGDDVSDLPYKDRMMAAEKMCLALERVCPAMSTGGRREVYIPHLTVVAQRFRLKELVDTAIRSQLTLNSVRGDQSVTFTEHGRAFFVRAVRGQCIVNAESNWHIYFSRSSKQLYASSPGRQPVFKGEWLKQGVYSNFWQTSIHRKTALPRHAFIWRWEQNYDNGYGPRVILDDELNSGGLTLKYLANKINTFEQEFKQK
The following text describes a protein:
Function:
Downstream target for both neurotrophin and ephrin receptors. May play a role in nerve growth factor (NGF)-induced recruitment of rapgef2 to late endosomes and neurite outgrowth.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cytoplasm.
Sequence:
MDTTTSIKMTTLAIQNLFSYVEEENLAAVKVHLDKFKEVDGRSDNGQTPLMLASEQGSLEIVQELIRRGANVNLDDVDCWSALISAAKEGHVEVVKELLENSAYIEHRDMGGWTALTWASYKGRVEVATVLLENGANPNTTGQQYSVYPIIWAAGRGHAEIVKLLLEHGAKVNCSDKYGTTPLIWAARKGHYDCVMHLLENGADVDQEGANSMTALIVAVKGGYTEVVKELLKRNPNVNMTDKDGNTALMIAAKEGYTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLHKYADIDIRGQENKTALYWAVEKGNATMVRDILQCNPDTETTTKDSETPLIKATKMRSIEVVELLLDKGAKVSAVDKRGDTPLHIAIRGRSRRLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTESDGDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQVEPLFQFSWLVVLLSLLLCGSVALVLGFTVDPKLAIAISLSILALLYVFFVVVYFGSRREGESWNWAWVISTRLARHIGYLELLLKLMFVNPPELPEQTTRALPVRFLFTDYNRLSSVGGETSMAEMIATLSDACEREFGFLATRLFRVFKTEDTQGKKKWKKTCCIPSFVIFLFILGCLIMGMALLAVFKVDGQNQTVNAVLVSMASVVGLALLLNCRTWWQVTDSVLNSQRKRLHSAANKMHKLKSEGFMKVLKNEVELMAKMAKTIDGFTQNQTRLVVIIDGLDSCEQDKVLQMLDTVRVLFSKGPFISIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSSAKKMCAPAPANGETGNSEGWHEELDRKLSQNSLGDQTKFGSKTTLNRRDTYRRRQMQRSVTRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQISFNWDRLASWINLTEQWPYRTSWLILYLEETDGIPDQTNLKTIYERISKNIPTTKDVEPLLEIDGDVRSFEVFLSSRTPVLAARDIRTFLPCTVNLDPKLREIIADVRAAREQVNMAGVTYPTLPLQEGRPISMYSQQSSACSPTASFNGPYNPPGVSPQPHSAYFSGMAGPQHPFYNRGSASVVSGTPSILLSSMSTDVICERVKLIDGIDQNLISQYTATIKKANINGRVLSQCNIDELKKEMNMNFGDWQLFRTSVLEMRHVENQVLHEEAPSEQGSITVGHVEPCRHAGAAAQGVAGNTDTSPMYNFNLSFEELSNVGLEEPPRHVNATWMGTTHRTPSMSSLNSQESSNEICKLTDKQQAEYRNAYEDYIASMSQLELGMEKPVPPFVSQLMHSSSEDKKKDGNDQDGRKSVSKRGSTKSGSDNTDYASADAATLDPITEEDEKVDHGSSKSLLGRKTSGDKVSLFQGADLKLKAGGGSRYQKLTSDDEESEESDNAPLLKDGKKPEAKASDGGDRSLTKGKDYLSDKKDSSDSGVRSNESSPNHSLQDEEADLSQSERANLIELDEENSARKRGLPNSLSGLQDPTIARMSICSEDQCSLLASSPEESWPSSKSYNLNRTPSNTTLNNNTNAQQGNHIRQPSDSSNTTSTTTGSDVIINPGTSTTSATTQNENVRVVHLKRGLNPGDPPEILKVSSETVTFGEERESIL
The following text describes a protein:
Function:
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (By similarity). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (By similarity).
Subcellular Localization:
Cell junction, focal adhesion. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Melanosome. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Secreted, extracellular exosome. Membrane raft. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (By similarity).
Sequence:
MSLYPSLEDLKVDKVIQAQTAYSANPASQAFVLVDASAALPPDGNLYPKLYPELSQYMGLSLNEAEICESMPMVSGAPAQGQLVARPSSVNYMVAPVTGNDAGIRRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTVTMHKDSSGHVGFIFKSGKITSIVKDSSAARNGLLTDHHICEINGQNVIGLKDAQIADILSTAGTVVTITIMPTFIFEHIIKRMAPSIMKSLMDHTIPEV
The following text describes a protein:
Function:
May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.
Domain:
The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.
Sequence:
MIRAFSFPVSPERGRLRGWLEGSLAGLCELHWLRERQEYRVQQALRLAQPGMGGAEAEDEEDADEDEDAAAARRAAAALEEQLEALPGLVWDLGQQLGDLSLESGGLEQESGRSSGFYEDPSSTGGPDSPPSTFCGDSGFSGSSSYGRLGPSEPRGIYASERPKSLGDASPSAPEVVGARAAVPRSFSAPYPTAGGSAGPEACSSAERRARAGPFLTPSPLHAVAMRSPRPCGRPPTDSPDAGGAGRPLDGYISALLRRRRRRGAGQPRTSPGGADGGPRRQNSVRQRPPDASPSPGSARPAREPSLERVGGHPTSPAALSRAWASSWESEAAPEPAAPPAAPSPPDSPAEGRLVKAQYIPGAQAATRGLPGRAARRKPPPLTRGRSVEQSPPRERPRAAGRRGRMAEASGRRGSPRARKASRSQSETSLLGRASAVPSGPPKYPTAEREEPRPPRPRRGPAPTLAAQAAGSCRRWRSTAEIDAADGRRVRPRAPAARVPGPGPSPSAPQRRLLYGCAGSDSECSAGRLGPLGRRGPAGGVGGGYGESESSASEGESPAFSSASSDSDGSGGLVWPQQLVAATAASGGGAGAGAPAGPAKVFVKIKASHALKKKILRFRSGSLKVMTTV
The following text describes a protein:
Function:
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.
Subcellular Localization:
Nucleus.
Sequence:
MSERESLNSQLEHLQMRYVGTGHADISKHEWLTNQHRDSLSSFIGHSSFLSLFSIAENESVGRVRYNTLTKMISPCGPAPKIKDNTMDKEEKND
The following text describes a protein:
Function:
May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.
Subcellular Localization:
Nucleus.
Sequence:
MTLSSEMSEASALAEETDIDVVGEEDDEEDEEEPQPRHRRRRRSYAEDEEEEEEEEEEDAGDLHDDALLPRSPVRAGGGGGGGGGGGGAGGGDGPGGSRPPSRGGPQKAAAAGGGGAGGGGGGGGGAGGGGGGGGGGKNSLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKRQQLPAPELLLRAVDPAAFLPQPPPQPPQQPPCAYGPYGCGYGLQLQPYHPHSALFAFHHPSPPPRQPPAAPAGAPAAALPPPPPPPPPPRRRAPLLPAAELARTPFGYPHPLGPALAASLHAAKPGSGAAVARSPFSIESIIGGGPGPGLGAGPAPGAGGSCASQSGAATGLSRSLGSGLAPAAALPAAPGLAARISNC
The following text describes a protein:
Function:
Probable transcription factor that regulates organogenesis during transition from the vegetative to the reproductive phase. Regulates the expression of CYP78A11/PLA1, HD3A and MADS1 during reproductive development in rice. May act upstream of CYP78A11/PLA1 during panicle development. Acts independently of the photoperiodic and gibberellin signaling pathways.
Sequence:
MLHHYYSGGAGHHQDVAAAGSPGDMASSTFSLFFPMSNGQCWPPSTVEESAAYDDHSTVTTSPSSPSSSSTGSVDCTLSLGTPSSRRAEPVAAAAPAANHGAPVPAHYPSLSAATVSWDATAESYYCGQQGRPATGAAKCAAGAGHDALLDRRCANCGTASTPLWRNGPRGPKSLCNACGIRYKKEERRAAATTTTADGAAGCGFITAQRGRGSTAAKAAPAVTTCGEETSPYVVGGGGGGGEVADAAYLAWRLNVVPPAATATAFSVWPERASLYHYN
The following text describes a protein:
Function:
May act as a guanine-nucleotide releasing factor.
Sequence:
MEPKEATGKETVVTKRKNLPFLRPRLYMLERRKTDTVVESSVSGDHSGALRRSQSDRTEYNQKLQEKMTPQAGGSVAETPTQEEEHQMQRMMAKRSKIIKELIQTERDYLNDLELCVREVVQPLRSKQIDRLDVDSLFSNIESVHQISAKLLSLLEEATADVEPAMQVIGEAFLQITGPLEDVYKVYCYHHDEAHSVLESYEKEEELKGHLSLCIQSLKKIYMQEGKPNLLDMGSLMIKPIQRVMKYPLLLCELRNSTPPCHPDFRALEDAFAAVRDINVNINELKRRKDLVLKYKKNDEDESLKDKLSKLNIHSISKKSKRVTNHLKILTRGESQVKDNTFNREEKLFRSLEKAVRHCVKNISLCLQHVQDATPLALHSAMALQEVSCDKDEEERGHSEAPSKAPNPCEDFAVGLQKLVLTPLSALLSLFPGPQKLIQKRYDKLLDCNSHLQRAAGAEPGLAKKEYEALNAQLVEELQVFNRAARAILSNCLCSFVALLGDLTLAARRLYSTAGPIPLLASTICEIQNRVLEEVQNLNFVKDNSATFIERKLSFEKKKPVQIPPEAPRQTDAHRSKLLSTYSTEELYQAKRRCNATQEYDINLLEGELVAVMEQKDPLGSTSRWLVDTGLMKGYVYSSFLRPYNPAKVQKVDAEHRFCDDDFDNISLFVSSRPARDSVTGTPEGSVSDSSSSLSGTCGKSEANGTDADSFQEVDEQIFYAVHAFQARSDHELSLQEYQRVHILRFCDLSGNAEWWLAEAQGQKGYVPANYLGRMTYA
The following text describes a protein:
Function:
Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.
Sequence:
MRVIRAYDGRSIVVNQPLSQFASLDDLLDCLSLATEIPSDSIICMTSDGSQLKQELLDRIIQQTATSPSESSSAAVVEPNPSSSTHQDAHHQSQNYEFFVYNREFLYTDPTELAAELAEHTVLEPVPPMLDVELTFPPTPKSLEALVSWSAEIATLVATYEQSCHDLLERITLIARSLQVALANLRDHADNIEKGANALIDDVAQKELKRMHSLLQGYERDLCILAMVSIHPRLQSTSAQMANAAATSSTTSAQNGNGPANGQSGLTKPKHRTLGDYISKSKMSAVADACHRVYTELRERIERIQTELSLVRNDTQGLSEEVQSTTPEVADETYQRAVEAQLRTQQLYAFICSTCSPDPQGWPVADKIDQETFDEIVRSSNELLLLDEVVREAVQRLTQDRNDILERSLHLLIDISAIQSEFTETGSLLAAVDADLHSNKLDGFKHLHRLKNMLWAYGATVVEVVRRREFAKHFLGKSQSLAELMAKVSASEWKRRQFYRSDVSSLLPWEVKGMDDKPPSLEITTPRVSSEGMADLGLADLQALYELLDHIDYQLREDGIDGVDSPIPEVKAALQALAAALQDLDDEFIHLVNHQLLNRQEQEDEASDDQGDESGSDTSIRARQRLRRRQRLSAPLAAANAQELTQLRSELAAAKAAQEQAEHGLKAETETRLVRLKTEIETLRRQVQTGKADVAKLEAEKREAEARIDTLAADLELERERRLNMVDEVNQLRRDLEQSHRIEAQAKQEVIEEADRVAELEAQAHELHVELEEAKRARIDASSRIEALLSEGSSFEGELRTAQARIEELTEQLSNAHAEAAKAREAATEVETAKERQIRSYRAEADGDRAILEEKVRALKADLDAKTKLLEKQTSIATRAEQSRIPDREAIDLLRGQLRAADVAHEEIVKEMDHAKELANEAEASRREVEASRQLLLERSRGLLAKTSLLRKAVRDMPKHTSSRQALSSEAAQATDKNNANAASTPALAASSGAVVAAQRAIAASTGSLSVSELSESQRQAALDAFDAEAEGATLETTLEALRALDVSEMYDEIKGKLDSLNIVVRKWQKAWKSANEKANKANHAAREKIAFKNFQVGDLALFLPTRSSNLAYKPWAAFNISFPHFFLNAKGALAEQLRTKEWVVARITSINNKVVPTASQVKSLIQGESDADANPFRLPEGVRFFMLDVETYGGHSSAPPALRSRKSSSATVDGGNGAANDPSSHLKDASSHPRSRSEGTLTGLKGLVEEHKNAPGGGAEPSVAKPSQLQSIAAEASKSTTPKAVDDQQIVPDDEAAGRTSGFSLHSDKIEAPEQSTPPMQTPDTSPRLGSTAVLSAPSLAEKGRSKAQQDDNTAETRSAISTSALTRVMRSASSASSFRTEGGISAGGVGRWRAGSSASANAAHWPSRSITGIAEEPTARHRDGNDADTSSSTDSTSHRSTLIEHATMTPAFGRAPNKRRFEAAGRTHNESRSGRAAAAADAAARRHGESQSPETGLLDGCNARSAPASQSRSEGITIRAPQPLHSDLSDTAVSNPFSQSPGPASLPADREGMGTLLRGQTRRKSSLHITSSASVDDEVGKREAPKVQRWPSDAVSKASQRTTSSASTASAPSQASGGIRINGRSIVVDAAVLTGAHRSEASSSSVATTAVTAAHAIPGAFPSSFSSSGSLASPASPSVGQGQTEEAGLSSSTVRQAWRSPRFSGAASPSRPTLSGTQKPSFLSQTLGRFTGAAAQAVQAPPFAPIASESETARKRRVSRPSLLQAIAPMQDAGGAEAEAASGTWQQTHRGTPESTASGVSGFSSMSGNGAQGMLKRLQGQQGSLR
The following text describes a protein:
Function:
May be required for the activity of an ISWI chromatin-remodeling complex.
Miscellaneous:
MISCELLANEOUS: Present with 3060 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MVLLNRRKIQPKEIGQSADSFSETPWVIKESSERINDYDSDLKKLDFYKRDIFTCEISGKDGLSYFKALKSEEQHREKVRYLLPKELRKAIANFANFSPIRKVGHLVESAFQRFSNRFFIGDTVCLKTIQKNALITYKEGEPNLVESPTIENNVTLFLVKDVFQSNGMMESEKGEISAPKLSLYLITECLNRESKGAALIVGQNEIKRPESHFSKFIIACFLNEILIKVSNKEHAPWRVKQEYIERYDVNPKCSPNMIDYLPDRMNSSSSELYTPLTIPPESDVEPADWKETSETSETSETSLSKIKAIDDEISVSFDHIYDNVNSLAYNDLKGTVDDKELPFTGPSIPFENISYLDSSLEYKNIDQKWFKECSQFPTERLLVVYQFLSFFGRFIGLSHFNFDQFLTTIKCTSPEALVDEYVKINFLKTYNSKGSFTNEKPRNEIYNQVTSSNVSQREKANVFNADESQRIPSNFTRNQKMRKFITDKSTEFVMYSIFKGKPLKNDDMEFQSYEKVNILYIDIVCSLMCLMTDNEPDWNCNLMDNWTEEKRKEEGNKTEIDIAIEKCLNYGDTSWVKLLHNKNFSNGNWLICLLGILQQNTHMIAYSDVAKCITKKILPLSMNFVNLGDELWDNFRKRLSIKDKIDVLWVLVDFASNFSSYIKELVDKVPKLCNGIRLKLDSAKKEYIKLKRQLKTLTKNRVKLHSNVSMNRYGSDECKGKVNALKVKIAYLMEDIAFLEAKLIQSDIKRLEILGKDRNGNRYYWMDSNGSSSAISEKNEELYNCCFLWVQGPSEADINFCLDVDVESLKKWELLAKAKGTAYATKEVFSIFRSTDGSYYQIAQGENFMIINSNGILMRPTIPAFIDKKIISETPEKLLLSHHQWAFFNDIEDIHMLVDRLDDLRENEGQLKKALTSKMDRIEVSYKQQFKIKRRIECDETFKKNHKLLKNNEFTFPELKRIETTCTSNGQHFSNMEKISKKLSRTKNDLVLEAILKDVAHLGECERALLKKQQNLIYPLNFHFEQLRTIDLEFIVETKRKRQEDILTKLLNHQRYKHISHVSGYGISSQRVDKAAHLDVQGILEEIECQLISRRREDEERN
The following text describes a protein:
Function:
Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of eRF1 thereby promoting the translational termination efficiency of eRF1 (By similarity). May be involved in regulation of chromatin structure, promoting expansion of heterochromatin.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MASEERDGDVLLQLHPEEVVETDPQLPEEIERCSGLDYNDFFWRYMHKNIPVIIANVSNDWECQNWTVGQSSPESRDLNSNPSASSINFDYLKTKISDGPVPVANCNSSYFNSHTKLELNFHDYLAKWRSSIESQSSAAWTSAEVNSNVAPASGDNLYLKDWHLAAQMPGYNFYKVPKYFASDWLNEQLIQQGKDDYRFVYMGPKNSWTSYHADVFGSFSWSTNIVGLKKWLIMPPGEELKLNDRLGNLPFSIDEKMLDEHNVRYYTINQRANEAVFVPSGWFHQVWNLTDTISVNHNWFNGCNISMVWQNLKNNLKAVCNEISDCQQMDNFEAHCQTMLRASFGINYLDFIELLEFIAARRLAEGTVATKFLLFDSYTMNDYHVQYDLECLWKITRTLTEDPTIQCSPLQLEDRCQGLLARLEF
The following text describes a protein:
Function:
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Sequence:
MMILWIMGKAYLSKEIRDVCINFDRRIKEIKSICKPDIALPKGTLILPGAIDLHTHIRGLKLAYKEDVVSGTSEASYGGITLIGDMPNSVPFVNTMETITAKLREFEYYSRVDYFVYSGVTKDLKKVDKFPIAGYKIFPEDLEKEETLEVLKSMKLKILHPEVPLALRGNRKLRLNIWYEIGALYYVKGYQNVHITHATNIRTVRLAKELGFTVDITPHHLLVDREKECLTKVNPPIRDTNERLWLLQAINEVDTVVSDHAPHASFEKQQPYEICPPGIAALSFTVPFILTLVSKGIISIDRAVELISTNPARILNIPYGEIKENNYANFTIIQFKDWRYSTKYSKVIETPLDGFPLRASIYMTIIQGKVGSLEGEVFPVKGINPFGENK
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MTEGNSTVCPPSDMILLSGLWANEIDIEVLSEFLFPVLIMQTSVILALTRFLAYALKPFGQPRVVAELIGGILLGPAAFGKLTYNSASAENAGSPGTSVVKPLYRFLFPPTSYTLIEAIGFLGLIYYVFLVAVELDVKVFRVMGRKVVAVAMASLTLPLLATAAIVAVFGLPAPMANNSYKASGTEQAAFVLLLSFALSITAFPILARLLAELKIPNPEVGQVVLPSALVGDVVSWLLLALCFALIGPGDKAAAHEYLAPFWMVLAAACLVLVCLYMVRPLLEWTLRQMPEGEPVNNVYMGLVLIFVLGAALASATVGFHPVFGALVLGLAVPKGPLTTTLIERLDDFVIGFMLPFLIVGCGLKADVASLMRPEGNEPTHYVFWLGCIVVVATLAKVAGCMIISSFYSMPRSQGLSLGILMNTMGPAQAIILNMGKSEKVFNQKIYALLVVSSVISTALVSPLVTALDRKCRGPAIYKQRNLELSRRDSDLRLVACVHTVRNVPSVISLLQLSNPTHDSPLLVSAVHLVELTGRTPPMLIVHEAGAIGTLTRRNTDNAPPDLVHSEPIVSAFEKYQQHAGCVTLQALTAVSAYSSMHEDICNIAADHQATLIVLPFHKLLTVDGEMEVINPAIRAVNQGVLTNAPCSVGILVDRGLGEHGKFANAGHYTPLHVAILFFGGPDDREALMYGRRFLEQPGVVLTVVRFLPSYEAEAPAAAPAVWPAKVDRLWDDECIRDFRLQFGDNASVSYTDKVVNDSSATVAAILSMGSIYDFYVVGRASGGGSPLVVGMTEFTDFPELGPIGDLLVSSDMGAMVSVLVMQQYVEERIE
The following text describes a protein:
Function:
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Sequence:
MAPPQGSRAPLEFGGPLGAAALMLLLPVTMFHLLLVARSGPARLLGPPPYLPGLEELWSPWALLLCLTWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGVSAGLPLSALPEMLLPLAFAATLTAFIFSLLLYLKALLAPASALAPGGNSGNLIYDFFLGRELNPRICSFDFKYFCELRPGLIGWVLINLALLIQEAELRGSPSLAMWLVNGFQLLYVGDALWYEEAVLTTMDIIHDGFGFMLAFGDLAWVPFTYSLQAQFLLYHPQPLGWPLASFICLINDLETISTATGRRLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVFHLLPYFYFLYFTALLVHREDRDERQCRQKYGLAWHEYCRRVPYRIVPYIY
The following text describes a protein:
Function:
Involved in the activation of the KinB signaling pathway of sporulation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQIFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDLMYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITALEWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK
The following text describes a protein:
Function:
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
Sequence:
MDVVQQVAHLPQPSIDDDLKLETANDRKTTWNDIQVINVQKWLNVNRDKFLPPVANHFMHDDGQLTVMFVGGPNDRTDYHIQCGEEFFYQLRGQALLKLMVRGQPRDIFLREGDIFLLPKRIPHSPQRFVDTMGLVLERKRAAREIDVLRFYTMKSGRPEILYQDSFHWDNAKTDMAACLERYSKSEQCKTGNIVPGLIFDTPLTVNVVSDVTEPFSLFQWIYSREDEINANGKLEIFDTNLYKYEILVFGQGKQEHGSEEAQIWLYQLVGSSKIITDEQMFKLSKQDSLLLPIDRKFQVVQPQGSYLLSCSQRP
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.
Subcellular Localization:
Cytoplasm.
Sequence:
MSENKVNTLITDSTSEAAKILLKGGLVVFPTETVYGIGASAFDIDACKRIYKVKNRPSDNPLILHVANFSSLKDCGEIDDRANLVFQKLSPGPITGIFKKKNQNLFTAGLDSVAIRIPSNPTALGFLKFCKIPVAAPSANFSGKPSLTKIEYILEEFIGKVDCILKGEEPQIGIESTVVDFISKPPILLRPGFIDKNDLSEILPDLQEMKSLDKNSYTTPISPGLKYRHYSPNCKVIFKNSLKGIPKEFAQIGFHFESNSVYQVLVSSNKEYMKEIYSFFVECDRRGITEAWCEIPKEEKWKEVLINRISKAASK