lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of a regulatory phosphorelay system that controls B.abortus cell growth, division, and intracellular survival inside mammalian host cells. This signaling pathway is composed of CckA, ChpT, CtrA and CpdR. CckA autophosphorylates in the presence of ATP on a conserved His residue and transfers a phosphoryl group to a conserved Asp residue on its C-terminal receiver domain. CckA-P transfers phosphoryl groups to the ChpT phosphotransferase.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Sequence:
MRPKWCKTTVLASFPRGSACTARQLKHSANRIYLDARASVPARRAGILNEDRIELPDDAIGASAERRSTRDLRKPSRAGIQHERAVGLMSRQTDNTYPKPLVMPKRGPSAALRLLIVGILLMGAAFIYFLFRDQLGDGFALVLMGVLSMVGVFYLFGAATGLIQFSQRSDHQDLAHSFMDTQPEGTVISDPRGQIVYANQAYARMTGATDADGIRPLDQVLASEPAASDAIYRLTNAVRDGLSAQEEVRISGGLSRGANGSLAPVWYRIKARALEGGAEFKGPLVAWQVADISEERAEQERFFQELQEAINHLDHAPAGFFSANPAGRIIYLNATLAEWLGVDLTQFTPGSLTLNDIVAGSGMALIKAVKAEPGTSRNTVIDLDLIKRNGQSLAVRFYHRVQTARDGMPGTTRTIVLDRAEGDDSSVAQRSAEVRFTRFFNSAPMAIAAVDAEGHTLRTNARFLDIFSGVVDRDAIDRRVKLENVVHERDRETFNKALAAAFAGQASISPVDTVLPGNEERHIRFYMSPVTDLGGEAAEEAAVISAVETTEQKALENQMAQSQKMQAVGQLAGGIAHDFNNVLTAIIMSSDLLLTNHRASDPSFPDIMNIKQNANRAASLVRQLLAFSRRQTLRPEVLDLTDVLADLRMLLARLVGKDIELKIDHGRDLWPVKADLGQFEQVAVNLAVNARDAMPEGGQITLRTRNIPAADAAKLHYRDLPEADYVVFEVEDTGTGIPADVLEKIFEPFFTTKEVGKGTGLGLSMVYGIIKQTGGFIYCDSEVGKGTTFKIFLPRLIEEKRADDAPVAAKEKKVEKATDLSGSATVLLVEDEDAVRMGGVRALQSRGYTVHEAASGVEALEIMEELGGEVDIVVSDVVMPEMDGPTLLRELRKTHPDIKFIFVSGYAEDAFARNLPADAKFGFLPKPFSLKQLATTVKEMLEKQD
The following text describes a protein:
Function:
Oxidizes aldehydes to the corresponding carboxylic acids with a preference for aromatic aldehydes. It might play a role in the detoxification of aldehydes to avoid cell damage.
Subcellular Localization:
Periplasm.
Sequence:
MKAFTYERVNTPAEAALSAQRVPGAKFIAGGTNLLDLMKLEIETPTHLIDVNGLGLDKIEVTDAGGLRIGALVRNTDLAAHERVRRDYAVLSRALLAGASGQLRNQATTAGNLLQRTRCPYFYDTNQPCNKRLPGSGCAALEGFSRQHAVVGVSEACIATHPSDMAVAMRLLDAVVETITPEGKTRSITLADFYHPPGKTPHIETALLPGELIVAVTLPPPLGGKHIYRKVRDRASYAFALVSVAAIIQPDGSGRVALGGVAHKPWRIEAADAQLSQGAQAVYDTLFASAHPTAENTFKLLLAKRTLASVLAEARAQA
The following text describes a protein:
Function:
Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane.
Sequence:
MEANGIAHDSSSLGAGRRDKREVGDKMVEDLSKYAHSPAHLAVARRDHASLRRIVSALPRLAKAGEVHTEAESIAAELQADEVSSFIDRRDVPGRETPLHLAVRLRDPVSAEILMAAGADWSLQNEHGWSALQEAVCTREEAIAMIIARHYQPLAWAKWCRRLPRIVASASRIRDFYMEISFHFESSVIPFIGRIAPSDTYRIWKRGSNLRADMTLAGFDGLRIQRSDQTFLFLGEGYVAEEGNLTLPPGSLIALSHKEKEITYALEGAGTQPTESEVAYEVSLMSQTNKERMQLDSALHMGNSDVTYEDEEHGAFDGQENGSAASCETSEANGVVKEKKSWFGWNKKSSNQRSADQQKSASDFLREDSVDSKKGKDKNIKKKKKGANNESEYKKGLRPVLWLTPDFPLKTDELLPLLDILANKVKAIRRLRELLTTKLPHGTFPVKVAIPIVPTIRVLVTFTKFEELQPVEEFSTPLSSPAHFYDAKSKESEGSSSWISWMKGSRGGQSSDSDSHRYKDEVDPFSIPADYKWVDANEKKRRMKAKKARSKKHKKQAAAKGGDGVQHQRTEDVEEQ
The following text describes a protein:
Function:
L-AraDH initiates the degradation of L-arabinose. Catalyzes the NAD(P)(+)-dependent conversion of L-arabinose to L-arabino-gamma-lactone. It is highly specific for L-arabinose as substrate and can use both NADP(+) and NAD(+) as electron acceptor, with a slight preference for NADP(+).
Sequence:
MARIAVTGAAGNVGRVTVEALASDHDVTPITHREREGLDSVILDVRDEDALTEAFEGHDIVVHLAANPNPDAAWDSVYEVNIGGTYNVYEAALAADIDRLVFASTNHVHQMYNIADATRPETLAADAEAVGVSDPPRPDSYYGVSKVFGEALGNYYADRHGLEVLNLRIGWLLTADEVREKMDEEESVARYVRAMWLSPGDCEQGMRRAVEASLPDSPLAVNLISANDDRYLSLTETMRAIGYRPRDNSATVVE
The following text describes a protein:
Function:
Involved in ER-Golgi transport.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MDDVERIQSENENLRKIRNRLMQWESKTDPLAALSIQQEEHLDVLTNLWRDSGPSAPAPTTPTQVGPTDSSAAATSQSGDDIRLPAEGLQNTNEFLLWFADVSAEIEQRGDADYHKYLQQLEQRKAECSHMLDQIAGAMERLGALCDEYDFVSQKTSALNTASEQLIEEQERLQELSHEIQRRLHYFSQVELLNQRLQSPTLSVASEAFRECLNKIDECLNYIEENPKFKDAAAYNVKYRQCLAKASGLVRNYVTSVINQATEATLHPKNNMPDASAALKAPDAAFALYYGKYQTAAAKVKRVAQLIESRSEHSLDYAQLMADLQQHYLAQRASVMSPAVNLSIQNVKVAHKGDHCSLTRSACAFLVHVCQDEQRLFYQFFSTGAPHLTVYLEGLCTILYDTMRPFIIHINHLETLAEICSILRIEMLEEHVQQNPVALEAFATIAHQLLQDVQERLVFRAHLYLQSDIQNFNPSSGDLAYPEKLEMMESIALSLQEPAPLRRSDSRNSMVSSVSSAVETESVATAYTVKQMNSPADLHGMWYPTVRRTLVCLSRLYRCVDRPIFQGLSQEALKLCIQSVSHAAGKISANKTPIDGELFEIKHLLILREQIAPFRVDFTVKETSLDFSKVKTAAFGLLQKRKQLFSMGSNNALLEFLLEGTPQIKEHLLDSRKEVDRQLKSVCEKYIKDAVQMLVGPLITFLEKAQSLLAQSTPATPQSPESTKASYVLRQSPWASPQQISSIIQETQRLIKAKLAVLQRSMQLYLSNRDTEFIIFRPIRNNIIQSFVKLEQLLTTNGYSTDDMIITSCPSAEQVSILLSSASILAAEGVASFAAAARKISTSSSVEGSTVGRKLSAMSNKSELVEEPKVEEVAGQIEVVPAEVQPPAKIEEEEVTETQTQANSE
The following text describes a protein:
Function:
Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differentiation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.
Miscellaneous:
MISCELLANEOUS: Mutations in CSF3R acquired in multipotent hematopoietic progenitor cells and resulting in truncated hyper-responsive forms of the receptor, have been identified in most cases of severe congenital neutropenia (SCN). Patients carrying these mutations are at risk for developing myelodysplastic syndromes and/or acute myeloid leukemia. Constitutive mutations leading to hyporesponsive forms of the receptor are responsible for the refractoriness to CSF3 treatment observed in some SCN patients.
Subcellular Localization:
[Isoform 2]: Secreted; Cell membrane; Single-pass type I membrane protein.
Domain:
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding; The box 1 motif is required for JAK interaction and/or activation.
Sequence:
MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCGTAWLCCSPNRKNPLWPSVPDPAHSSLGSWVPTIMEEDAFQLPGLGTPPITKLTVLEEDEKKPVPWESHNSSETCGLPTLVQTYVLQGDPRAVSTQPQSQSGTSDQVLYGQLLGSPTSPGPGHYLRCDSTQPLLAGLTPSPKSYENLWFQASPLGTLVTPAPSQEDDCVFGPLLNFPLLQGIRVHGMEALGSF
The following text describes a protein:
Function:
Involved in the Wnt signaling pathway by regulating mom-4 kinase activity.
Sequence:
MGDDGFLDQYPANTDAGIGTVHSCRYSKQKNPVQNNDFLSCSMCIHNGPIKLYGIFSGFNGGDSTAKFVMNRLVYEIFGENPITPTLLPYQVVEEFKRKFENVAERYLLMNTDDLNNRLLKLEEQSETGNNAVSEINQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNLHNNDNPLEIVRIKGLGINPETVLNPTRAIGDLQRTHLFEETEAFKNAKGPPVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIPTEVSVRLIEDHTVTSTAQALVDSFARKHRDAYTMSDDKNFCISNHREEMTVIYVKLEEDYQAALYEQFDSAISTMESTNATLYEPCSTPYVDATNFNSGKNYEKMKKLLLTRPSK
The following text describes a protein:
Function:
Catalyzes the interconversion between UDP-glucose and UDP-galactose.
Sequence:
MAVRDHPRAYIPPSLAPGSQLQTSVSPPLSSPTRPACLSPDLEDSAVRLRRSVDPMPSPPAVARTILVTGGAGYIGSHTVLQLLKGGFRVVVLDSLNNSSEVAVERVRDLAGEFGKNLAFHRVDLRDREALESVFSSTKFDAVIHFAGLKAVGESVKNPLLYYNNNLIGTINLFEVMAANGCKKLVFSSSATVYGWPKEVPCTEEFPLCAMNPYGRTKLMTEDICRDICQGDSDWDMILLRYFNPVGAHSSGYIGEDPCGIPNNLMPFVQQVAVGRRPALTVYGNDYSTKDGTGVRDYIHVVDLADGHIAALQKLFEGSRVGCEVYNLGTGKGTSVLEMVAAFEKASGKKIPLVMAGRRPGDAEVVYASTTKAEKELQWRAKYGIEEMCRDQWNWASKNPWGYGSPETTNGNQLGYGSSESINGSIETANEKRSSETANGKYPTYGPFKITNGKRTAFESPKISNGKHPAYGLVHTASWKHPTCGLSETTNGKHPTHGSPKTTNGKYRIYGSPKIANGKHPTYGSLTTVNAKHVISK
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAEQATEEDILLAKRIIGAAERHDVPALKVLLKEGSANVQDTTTYDTATVSKSPLHAAIASCGKAEDGKEAGDEAVQTVELLLQNGAIWNDLSSEDETPGCIALKLGQKKIYDIMVEAGVRAEILFAKMEALGLGTNTAEEHDGEEATDEIAEDRPAVKKQKVSEGEVKEIQEVAEEPKLDDVSLDNHAYLKSELRYKEGILLDESDNAVMMDWEDQIMRRHAETINPKPGLKVMNVGHGLGLVDTAIQTHNPAEHHIIEAHPQVHKRLRETGWYDKPNVHIHEGRWQDILPKLIEQGVVLDGIYYDTFAEDYAALKEFFSEYVIQLLAPDGVFGWYNGLGADRQICYDVYTKVAEIDLYEAGLDTVWEDIDVPKGLHDKKNWEGTRRPYWTIDVYRLPINKFVK
The following text describes a protein:
Function:
FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-decaprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid. Also acts downstream of COQ4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-decaprenyl)phenol to 2-methoxy-6-(all-trans-decaprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to COQ6 from NADPH via a ferredoxin/ferredoxin reductase system composed of FDX2 and FDXR.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Golgi apparatus. Cell projection. Note=Localizes to cell processes and Golgi apparatus in podocytes.
Sequence:
MAAWVGARAAAGARGVYARARGVHDGWGPSQSYDVVVSGGGLVGAAAACALGHDVHFGRKKILLLEAGPERAPDRPPEKFSNRVSSISPASAALLASFGAWEHIRDTRCKAFRRMQVWDGCSEALITFDRDELDPVGYVVENDVIMAALTRRLEAVSDRVDVLYGSRAAELAWPSAGRGPEADPWVRVTLADGRRLRAQLLVGDGGPRGGGRGGEGSGPAPDPRPRPQVGADGRDSRARRAAGIRTVGWRYDQSAVVATLHLSEATDNNVAWQRFLPSGPIALLPLSDAVSSLVWSTSHEHAAELVGMDEEAFPDAVNSAFWSDAHHTELAAAAGSALRSALSVLRPAGTPARQLPPSVARVEPGSRARFPLGLGHAADYVRPRLALVGDAAHTVHPLAGQGVNMGFGDVAALVRRLGAAAFDGGDLGEEPGGRDPRRPGRGEGGRPGRAAGDGPVLGPAGSLSLLAGYETERQRRNVCLLAATDLLARLYSTAAAPLVLLRTWGLQATDAVAPLKVRPSPRRRGAESASPVTAPPGRRGPAAFARP
The following text describes a protein:
Function:
Involved in leaf senescence delay. May repress jasmonic acid (JA) signaling role in promoting leaf senescence. May regulate panicle development and pollination/fertilization process.
Subcellular Localization:
Nucleus.
Sequence:
MMMMGEGVSSVPPWSHLPVSGVDVLGGGGGGGDEMTPYVIAALRDYLPANDVGVGADEEEEAAAMAAAVDAYACDEFRMYEFKVRRCARGRSHDWTECPFAHPGEKARRRDPRKYHYSGTACPDFRKGGCKRGDACEYAHGVFECWLHPARYRTQPCKDGTACRRRVCFFAHTPDQLRVLPAQQSSPRSVASSPLAESYDGSPLRRQAFESYLTKTIMSSSPTSTLMSPPKSPPSESPPLSPDGAAAIRRGSWPGVGSPVNDVLASFRQLRLNKVKSSPSGGWSYPSSSAVYGSPKAATGLYSLPTTPLASTATVTTASSFMPNLEPLDLGLIGDEEPVQRVESGRALREKVFERLSRDGAISGDATAFATAGVGLDVDWVSDLIN
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (By similarity). Required for embryogenesis.
Subcellular Localization:
Nucleus speckle.
Sequence:
MGSHGKGKRDRSGRQKKRRDESESGSESESYTSDSDGSDDLSPPRSSRRKKGSSSRRTRRRSSSDDSSDSDGGRKSKKRSSSKDYSEEKVTEYMSKKAQKKALRAAKKLKTQSVSGYSNDSNPFGDSNLTETFVWRKKIEKDVHRGVPLEEFSVKAEKRRHRERMTEVEKVKKRREERAVEKARHEEEMALLARERARAEFHDWEKKEEEFHFDQSKVRSEIRLREGRLKPIDVLCKHLDGSDDLDIELSEPYMVFKKKKVRIGIWLNFQLSITNVYVEAEYKNDSACLLLRSRVDILLNKGLTVKDMEELRDDIKMYLDLDRATPTRVQYWEALIVVCDWELAEARKRDALDRARVRGEEPPAELLAQERGLHAGVEADVRKLLDGKTHAELVELQLDIESQLRSGSAKVVEYWEAVLKRLEIYKAKACLKEIHAEMLRRHLHRLEQLSEGEDDVEVNPGLTRVVEENEEEINDTNLSDAEEAFSPEPVAEEEEADEAAEAAGSFSPELMHGDDREEAIDPEEDKKLLQMKRMIVLEKQKKRLKEAMDSKPAPVEDNLELKAMKAMGAMEEGDAIFGSNAEVNLDSEVYWWHDKYRPRKPKYFNRVHTGYEWNKYNQTHYDHDNPPPKIVQGYKFNIFYPDLVDKIKAPIYTIEKDGTSAETCMIRFHAGPPYEDIAFRIVNKEWEYSHKKGFKCTFERGILHLYFNFKRHRYRR
The following text describes a protein:
Function:
Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm. Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein.
Sequence:
MSAGSPMSPLERASTAVEIEYGSDDEFGSEKPQGARSGLMDGLTSAVGQQVAANMFEAGKQSAESVYSSYARIDLLRPYFDVEPADIRYRLLKSLWPQFSSVPQIIPADLYGPIMLAFTLSAILLLGMKAHGHVAAREGTLIGTAFAVAFGFWATLSTILYTLGFIFNTNVTAFELVALTGYSMFSYCIVLLISHLHLAEYDFYMAWLVIGSLAALRLGFALRSRTPDGKQGIMVGVIAATVHWTYLLYLKLSYVTLYNAIV
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MIIALRLRKTVSPNLVFNLATMSNPNLSPFLFICLMIISSHSISICMADESNEASIRHRLMPGTSKNDMPQTTLVDDRRKTLNRINGVLRDTDTGGEEEFNYIEATALGPKNWGSLKPDWKICADGKSQSPINIDANSAQVMPGDLKRAYIDAPAVLINGVNNIGVIWKGDAGGIEVNGSTYKLVQCHWHTPSEHTIDGKRFDAELHLVHSNGMGQKAVVGILQNIGPPDPFIGNLTEEIDVLDTNEEIDLEKISATNIKDGSKTNYRYFGSFTTPPCTEGVIWTIEAQVRSISQGQINLLKGSHQREFRENARPIQLLGERQIWKFDLPGATE
The following text describes a protein:
Function:
Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones. Required for normal hearing.
Subcellular Localization:
Cell membrane; Single-pass type IV membrane protein. Cell projection, neuron projection. Cell projection, stereocilium.
Sequence:
MPGIDPAKRLHMEKWTPTARNEGKKAKMERRLRTTDICHCFSLSVRRAERGTPKRARACAVFPLPFIFPLPHPLPHRVVKKKGKMRDRTHELREKGDDSDSENAELEALVTRGSGKSNDLLDPTDEFFQTTRGIREALRTLENKVKELEKKQTTILATPLPEDSMKQSLQTLRDEIKELSKDIRTRLKKIEPKKDEEDENRNSVNTRMKRTQHGILSQQFLDLINKCNSIQSEYRDRNLERIKRQLQITDNRVVSDEELDQMLESGQTEVFVSNIMKDTQVTKQALNEIETRHSEILKLERSIQELHEMFMYLATEVELQGEMIDRIEKNILDSGDYVKKGQVHLQKAQENQKKARRKKFMIAICLTITLAIIITIVGVLIAVG
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MKTPFSVLLLASVLCFGPALAIITKNNWSYAGAGDTDQEFWKDIDGSFCDGSSQSPINIVTKWTREIERAPFNLQSYDTTIDATVENNGHALEIEVSKMPGEGHYDVTGGGLSGTFRAVQFHFHFGSNSMQGSEHTIDGERYPAEMHIVHYDTAYSSVSEAVKNKGGIAVLGFFLEVDDDDNSALDIILDQASNLMRPHTHQEMAGFTLSNLLPSSLDKFWRYDGSLTTPLCNEVVTWTLFEDTIKISNNQLNITRTLMSDAIDEAGYEMPMENNFRDIQSRGIRTIYAVTADDDYGMSPTPTASAGKSAPGAMIVLDAFLVAMALRF
The following text describes a protein:
Function:
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDAPPPSAVPSSSLDEQPSAALTQRKKLSSTMASSPELSSASNGGRTQTTKTTTTSQRNNPHYPTRTELVALALYPTLLLFGTLFSLLNPSARSSPYDFVSQSHVQSGDAIPSYFARKDNLFNVFFVKRAWFWITVSFFGFLFSHPGYNSNNNNNMTGTRGGDNGSGTGRKIKAVVRWGLVTLWWVFVTQWFFGPAIVDRGFRVTGGKCQEAQGRVNAQVKADAMPGPVGSNVEVAGLKEFVTAAACKAAGGKWQGGHDISGHVFLLVLGSAFLVQEVGWVVARHYWRRSVRDERTVVMGDGAVKSAGTDLAADKRWDDYSPEMDEAREVRDVVTGGGLWDALGHGGKVVFVVVGLSAWMLLMTAIYFHTWFEKLTGLLVALMGLYFTYIVPRFVPALRGIVGLPGV
The following text describes a protein:
Function:
Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.
Sequence:
MSLDLLLRGAVLVTPEGERRADLGIVGGQIAELTDEIATPAAQTLDVSGLHVFPGVLDDHVHLNEPGRTHWEGFETGTQALAAGGATSFLDMPLNSSPPVLTRERFEDKARLGEEKSLIDFGLWGGLTPLNLDQLDDLAECGVIGLKAFMSHSGLDEFPAADDLTLYEGMRTAKRHGLVVATHAESNEFTRRLTETARAQGKSGVRDYLESRPVVTELEAVQRALLFAQDTGAALHLVHVSSGAAVALAYEGKQKGIDVTIETCPHYLHFTGEDVERVGAALKCAPPLRDPAVQEELWRELLAGHIDTVGSDHSPAPPDMKTSEDFFSLWGGISGAQSTLNVMLEDGYAQRGLPLEIIAALLALNPAQRFGLPQKGRLAVGADADFALVALGEKFTLDTLYDRWQQNPYRGQSFQGRVHATYLRGQPVYQNGEFTGTPRGRLLRPRSL
The following text describes a protein:
Function:
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
Sequence:
MFPYPLVIFDLDGTLVDSASDIAEALNGTLQELGLQQFPEATVRSWIGEGVHTLLATALREAGSDRDVDAEMPVMMRHYEASLLHHPHLYPGVAEALPALRSAGATLALCTNKPARFIQPLLEHLGIAAQFATVLGGDSLPQRKPSAAPLLHLAQQFQHAPAQCLMVGDSATDAAAAQAAGMPLAMVRYGYLRGFDVEHAGAVAVIDDMRALLMLH
The following text describes a protein:
Function:
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.
Sequence:
MSSSKNGLIVPATINKRVGFLLSPKKKRKTIFDAFAQLCGKTGIELVEIDLNVPLEEQGPFDIIIQKITDYMAEATEGDEASEKTVQSLKVYLQAHPQVKVLDPLDSVEKLCDRVISYKVMKQCEIQDNGWKAYIPNFVAIDSLDQKENLRRIKEANVEFPMVCKSVIGHGSEVSHQMALIFNQEGLQDLNPPCVVQQFINHNAVLYKIFVAAHKYCTVVRPSIKNFYRNLDLKKTIFFNSHDVSKSDSDSHLSVLDKFDEDEDPTPTDNILVGKLVKRLRDKLNLTMFGIDIVVEKGTKNHVVIDINYFPGYEGMPSFPKDMLQYIHLLLGEGEEEVGLLDIGPPTIPVIS
The following text describes a protein:
Function:
Involved in pre-25S rRNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAKEPTPATMTDKKKTTKESEPTPKILHETHQKSKDKNAASSVGPSSSKSAESFEEKNRRTVFVGNVHIDCVKNKSASRALLEHLLNPSKEESGGLAPQARIDSIRYRGIPLATPIGSEPPKDQHGSKRSKAWQDSQAAGGTRPSFDDAAGGSAGRRGAKPLESSESTLPTVKFLTGGQKRKIGYVTGDIHPEAKSCLAYVVIAPPPPPPPSSSTTTSSSHPSAHLSAIELAQLIVAKSDGTSFMDRVIRCDMASQPPSKKTPNNPSSHTIDNKEQRRTLFIGGLDFVEEEDSIRKAVESKLVEEKKGLPEGAATWVERVRVVRDKATSLTKGFAYVLLRTQDAVEEMLALPEGSFKIGKRRVRLQKYLSSGQSSALKRVREPTTKNGEKRGGKPNPLNPSQDSTKRPRIDLTKEIQTTYQGPDQSQELALLDKSERKKIKSANQARVERRMLKKQNQLKIKILNSQKSSHKKQEFHNTLKPFKKSVVHKLASIKDTKNNNKNKAFKNKNKSKVESKSSDS
The following text describes a protein:
Function:
Involved in sphingolipid trafficking. May recycle sphingolipids between cellular membranous compartments.
Miscellaneous:
MISCELLANEOUS: Present with 521 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MNVLWIIALVGQLMRLVQGTATCAMYGNCGKKSVFGNELPCPVPRSFEPPVLSDETSKLLVEVCGEEWKEVRYACCTKDQVVALRDNLQKAQPLISSCPACLKNFNNLFCHFTCAADQGRFVNITKVEKSKEDKDIVAELDVFMNSSWASEFYDSCKNIKFSATNGYAMDLIGGGAKNYSQFLKFLGDAKPMLGGSPFQINYKYDLANEEKEWQEFNDEVYACDDAQYKCACSDCQESCPHLKPLKDGVCKVGPLPCFSLSVLIFYTICALFAFMWYYLCKRKKNGAMIVDDDIVPESGSLDESETNVFESFNNETNFFNGKLANLFTKVGQFSVENPYKILITTVFSIFVFSFIIFQYATLETDPINLWVSKNSEKFKEKEYFDDNFGPFYRTEQIFVVNETGPVLSYETLHWWFDVENFITEELQSSENIGYQDLCFRPTEDSTCVIESFTQYFQGALPNKDSWKRELQECGKFPVNCLPTFQQPLKTNLLFSDDDILNAHAFVVTLLLTNHTQSANRWEERLEEYLLDLKVPEGLRISFNTEISLEKELNNNNDISTVAISYLMMFLYATWALRRKDGKTRLLLGISGLLIVLASIVCAAGFLTLFGLKSTLIIAEVIPFLILAIGIDNIFLITHEYDRNCEQKPEYSIDQKIISAIGRMSPSILMSLLCQTGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSLYEKRSNYKQITGNEETKESFLKTFYFKMLTQKRLIIIIFSAWFFTSLVFLPEIQFGLDQTLAVPQDSYLVDYFKDVYSFLNVGPPVYMVVKNLDLTKRQNQQKICGKFTTCERDSLANVLEQERHRSTITEPLANWLDDYFMFLNPQNDQCCRLKKGTDEVCPPSFPSRRCETCFQQGSWNYNMSGFPEGKDFMEYLSIWINAPSDPCPLGGRAPYSTALVYNETSVSASVFRTAHHPLRSQKDFIQAYSDGVRISSSFPELDMFAYSPFYIFFVQYQTLGPLTLKLIGSAIILIFFISSVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRSFTVVPSETKKDANSRVLYSLNTIGESVIKGITLTKFIGVCVLAFAQSKIFDVFYFRMWFTLIIVAALHALLFLPALLSLFGGESYRDDSIEAED
The following text describes a protein:
Function:
Plays a role in erythroid differentiation. Involved in cell proliferation and tumor cell growth suppression. Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner.
Subcellular Localization:
Mitochondrion. Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MAGLLTLLGPAGRVSTRLRPLAPWLLGTATSCAPPLWALALSHPVPDARLLRTARGDCLSRQEPNRTPEPGGSVTGTEKKLSRTQQLKKVFQEYGAVGVSMHIGISLVSLGIFYTVVSSGIDMSAILLKLGFKESLVQSKMAAGTSTFVVAYAIHKLFAPVRISITLVSVPFVVRYFRSVGLFKPPATKP
The following text describes a protein:
Function:
Catalyzes the formation of branch points in alpha-glucans by cleavage of an alpha-1,4 glycosidic bond and subsequent transfer of the cleaved-off oligosaccharide to a new alpha-1,6 position (Probable). Is probably involved in the biosynthesis of 6-O-methylglucosyl lipopolysaccharides (MGLP).
Sequence:
MNTSASPVPGLFTLVLHTHLPWLAHHGRWPVGEEWLYQSWAAAYLPLLQVLAALADENRHRLITLGMTPVVNAQLDDPYCLNGVHHWLANWQLRAEEAASVRYARQSKSADYPSCTPEALRAFGIRECADAARALDNFATRWRHGGSPLLRGLIDAGTVELLGGPLAHPFQPLLAPRLREFALREGLADAQLRLAHRPKGIWAPECAYAPGMEVDYATAGVSHFMVDGPSLHGDTALGRPVGKTDVVAFGRDLQVSYRVWSPKSGYPGHAAYRDFHTYDHLTGLKPARVTGRNVPSEQKAPYDPERADRAVDVHVADFVDVVRNRLLSESERIGRPAHVIAAFDTELFGHWWYEGPTWLQRVLRALPAAGVRVGTLSDAIADGFVGDPVELPPSSWGSGKDWQVWSGAKVADLVQLNSEVVDTALTTIDKALAQTASLDGPLPRDHVADQILRETLLTVSSDWPFMVSKDSAADYARYRAHLHAHATREIAGALAAGRRDTARRLAEGWNRADGLFGALDARRLPK
The following text describes a protein:
Function:
Catalyzes the reversible oxidation-reduction of the R-enantiomer of free methionine sulfoxide to methionine. Specific for free L-methionine-(R)-S-oxide.
Sequence:
MNKTEFYADLNRDFNALMAGETSFLATLANTSALLYERLTDINWAGFYLLEDDTLVLGPFQGKIACVRIPVGRGVCGTAVARNQVQRIEDVHVFDGHIACDAASNSEIVLPLVVKNQIIGVLDIDSTVFGRFTDEDEQGLRQLVAQLEKVLATTDYKKFFASVAG
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYSGSQNSQNQTSSDFILVGLFGETKYALLLYTATFIFFLMALAGNALLIILVHMEPRLHTPMYFFISQLSLMDLMYISVTVPKMLLGQVTGDHTISPSGCGIQMFFYLTLAGAEFLLLSVMAYDRYAAICRPLHYPLLMNQKVCVCLVSGCWFLGMVDGFVVTPIAMNFPFCHSRKILSFFCEAPAVLKLSCSDISLYKMIMYLCCVLMVLIPIVVISSSYALILHLIHRMSSSESRRKAFATCSSHMIVVLLFFGATIYTYMLPDSYHTAEQDMMVSAFYTIITPVLNPLIYSLRNKDVTGALRSRMQSGLNLRKVVKRKS
The following text describes a protein:
Function:
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MGSPTHFGLFLISDAEREVHMEELKSQEASKSKPPSKPKSNFTTFSHGTPDLSKIHKVGMLATVCRTQGYFVLGGGPIIEITGVSNDHDNNNSNLVEITESKNDTSDSTTTTTTTPSTSITPITTPVVPQIPTSKYLKVSIEPHEYSELGDSLTVRALRLQLVKCIYSAINRYQDSSFAQHLKQICMLPIFKMDDSSLLNSIGPLCISSPSEYQKLLECKSLEEKLNMVLSMLVKKCEVFDFNFSIEKQLEEKTMAQQKKYFLTEQMKLIRKELGIDLDEKETIKNKFNSRWKEIAVMDKQILQVFKEEMDKLSSCESNSSEYNTSRNYLDWMTLLPWNVYTNDNFDISKVKEILDRDHYGLKDIKEMIQTFIAVGKLRGSIGGKVILLVGPPGTGKTSVGKSIANALGRQFHRISVGGLSDVSEIKGHRRTYVASMPGKIIQALKTVKTSNPVILIDEIDKISRSSQGDPNSALLEVLDPQQNKNFVDYYLDVPYDLSRVLFICTANDADSIPAPLLDRMEVMTLNGYIQSEQMEIAKRYLLPLVRKETGISEEQLQFTPEAIKKLCELYCREAGVRNLKKFIDKIFRKMAYKLSMGMEQSVIITPDNLEQYVGPIKYPSSRLFQKQKPGIVMGLGGSLIHIESALDRFTNGPTVTTTGSLGLVMRESIDISYSYVKDFLLKVDASNDYFLKNSIHIHAPDGSTQKDISSAGITIVSSLLSLATGKLVKPDLAMVGEVSLTGKVIGVSGIVEKIVLAKRESIKTIIIPKENKKQLEEIPDFIKEGIEIYLVDYYSDVYSIAFTNDSTIKPLIFNDNKENQNENENQSEVKSTIIQ
The following text describes a protein:
Function:
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
Sequence:
MVDKLTHLKQLEAESIHIIREVAAEFDNPVMLYSIGKDSAVMLHLARKAFFPGKLPFPVMHVDTRWKFQEMYRFRDQMVEEMGLDLITHINPDGVAQGINPFTHGSAKHTDIMKTEGLKQALDKHGFDAAFGGARRDEEKSRAKERVYSFRDSKHRWDPKNQRPELWNVYNGNVNKGESIRVFPLSNWTELDIWQYIYLEGIPIVPLYFAAERDVIEKNGTLIMIDDERILEHLTDEEKSRIVKKKVRFRTLGCYPLTGAVESEATSLTDIIQEMLLTRTSERQGRVIDHDGAGSMEEKKRQGYF