lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: May be due to an intron retention.
Subcellular Localization:
Nucleus.
Sequence:
MANKLIGEMGLHTKISNIFAARNIITAKDALSMTEFELMELLDVGMKEIRSAISFISEATSPPCQSARSLLEKKVENEHLSGHLPTHLKGLDDTLCGGIPFGVLTELVGPPGIGKSQFCMKLALSASFPVAYGGLDGRVIYIDVESKFSSRRVIEMGLESFPEVFHLKGMAQEMAGRILVLRPTSLANFTESIQELKNSILQNQVKLLVIDSMTALLSGENKPGAQRQPQLGWHISFLKSLAEFSRIPIVVTNQVRSQNRDETSQYSFQAKVKDEFKDNTKTYDSHLVAALGINWAHAVTIRLVLEAKSGQRIIKVAKSPMSPPLAFPFHITSAGISLLSDNGTELKGPGINTIHARGHSDMINFHGDCS
The following text describes a protein:
Function:
Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDAFRGYLAAQKGQHNQAASNNPPFHSDHEMHHYGAHPNTNAAPADDYYTPYLGLRARLSQTWINRWTILLLLIIVRLLISLSTINGDIASAKTEALSACTSVENVGSAMASMPHYLSQGVNSMAAAGITKAVNGMMEMLYLTLTGVEEIVLFVIHMMTSTYMCLITLAITGSLQVAIQMIEDVGAFMNKSIDTITGDMSSGLKSFEDDLNGFLSKINIGGIFGSSTSPPKIDLSSEINKLNSIQIDPSTMDADLAKLNASLPTFDQVQNFTDSIIKLPFEEVKKLVNESKIGYKFDDSVFPVPQKKSLTFCSDNTAIQDFFIGLVKTLNIAKKIMLIVLIIAAILACVPMAYREIWGWRSMQRRAALLKAHNYTNELDILYQAHRPYTSQFGLKLSRRFKGQKNQILARWFIAYATSIPALFVLALGMAGLFTCLCQFIILRTIEKEIPALAAEVGDFAEHVVQALNNASEAWALGANSVINNTNTDINENVFGWVNTTTGAINETLNVFTDEMTKALNVTFGGTILYKPIMGVFECLVGLKVAGIEKGLTWVSDHAHVEFPEFQPDVFSLGAAASLTNSTADDNFLANPATSTTDEITDAVVKVGKKLEAVIKQEALISASLVIVYFVIVFIGFVRVVIGMCGRDKSRAEGGSGPGTLYRNGFPHQHLPVIREEKFGSNASDGWHEEHMRAGGDTIRMPFGGDGAADDLPYDGAPAPKYEASIAPVTTEMGSERLGVVPGGRANTNRGPWVRDEKGREGWEADDAQMRATSSYGFLENGDEKSSGWGLPPRRV
The following text describes a protein:
Function:
Essential for nitrogen assimilation, distribution and remobilization within the plant via the phloem.
Sequence:
MCGILAVLGVGDVSLAKRSRIIELSRRLRHRGPDWSGIHSFEDCYLAHQRLAIVDPTSGDQPLYNEDKTVVVTVNGEIYNHEELKAKLKSHQFQTGSDCEVIAYLYEEYGEEFVDMLDGMFSFVLLDTRDKSFIAARDAIGICPLYMGWGLDGSVWFSSEMKALSDDCERFISFPPGHLYSSKTGGLRRWYNPPWFSESIPSTPYDPLLIRESFEKAVIKRLMTDVPFGVLLSGGLDSSLVASVVSRHLAETKVVRQWGNQLHTFCIGLKGSPDLKAAKEVADYLGTVHHELHFTVQEGIDALEEVIYHIETYDVTTIRASTPMFLMSRKIKSLGVKMVLSGEGSDEIFGGYLYFHKAPNKKELHEETCRKIKALHLYDCLRANKGTSAWGLEARVPFLDKSFINVAMDLDPECKMIRRDIGRIEKWVLRNAFDDEEKPYLPKHILYRQKEQFSDGVGYSWIDGLKDHANAHVSDSMMTNASFVYPDNTPTTKEAYYYRTVFEKFYPKNAARLTVPGGPSVACSTAKAVEWDAAWSKLLDPSGRAALGVHDAAYEEKAPASVDPVVDSVSRSPAHDVKRLKTAVSAAAV
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MSNKSVQYDKIFLNQSRNPGKLRIAASGLGWKSPDIKEPFTVPQSEIRRFCWSKFARGYELKLILKNGIPVSLDGFELEDFEDLQNVIKQNFDMTIEQKDFSLKGWNWGKTNFLGSDLVFEVNSRPAFEIPVASVVNTNLSGKNEVALEFSTQNDGPVPSAQSDQLVEMRLYIPGTTTREEAAEGEEATEQNLASVFYETLKERADIGQVTGDAIVSFSDILLLTPRGRYDIDMYEDCMRLRGKTYDYKVDYTSIIRLFLLPKPDDQHVVFVIGLDPPLRQGQTRYPFLVTQFIRDEDMEVDLNIDEGLLREKYADRLKSSYDQPAYEVVSQIFRGLTGRRVTTPSNFSSHHGHTAVKCSYKANEGQLYVLEKSFLFIPKPPIYIGMGDIARVTLSRVGASVSAARTFDLTFTMRSGTSYQFSNINREEQNVLVEYIESKHIKIHNDLADEAAQNTLLSAALDDEDDGTADMDEDDNEDEEFEAESESDVPEEYDENHISSSDVEEE
The following text describes a protein:
Function:
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MKIKNYFIIVFIIIVLSTDVISSQSSIEDKMYTSLNSYPCTRIMTLNGQIGCSSSHGGDSGILYLIDSDESYHNYFSYNQQKDIIVVFDSNYFNKTLVLEMYSKKKMNGALVLTDIGKTYPYSPEDQYPIKQFGLYPDSNLNWNPNGDGFTYMNFPFPMFALELKTSIIIRNLSTINRDGKYPAYGAELDSFMQGAINAETCLRRGFCEPVGGQSIWSSFSEVIDQSKPIILVMLPIDATAFFRDLATGTDQSGYALTVLLSMLNTLQGVDKTKWDKEVIFAMWNSERWGYVGSTNFVNDLLNFNCTSLDSNNQNSCSSPPMLDLTFEQIKFENIYAIIEFNQIGRPVNSGKKTPNKLDIYNLVFHPNGGAGANQLMDVFSQSTQSYENSTIQFQKTTQNELPPCSSMSFIKEINKKSAPNFIGTLVITDHDYQYNNPYFGDEQDNSGNINTTTSTLFDMVQVFSKSIDLLAGGNGTVKVDDLFIREINVCLTQSITCNWVTKLMSTFPYNPIPNFYSGVYGVSPVNHITPIETRFIFRMATYLTQHRTNATNCTSDNDCDTSSSICVNKVCLYSNTHYHNAISLAFSFDNSKSSWTIVNTSYPVFVESNWDYTTVRLFQVGSYANEIWFLVSGLIELLLSVGIIFYIKKYLSKRYKLL
The following text describes a protein:
Function:
Component of the cell wall.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MVKLTSIAAGVAAIAATASATTTLAQSDERVNLVELGVYVSDIRAHLAQYYSFQVAHPTETYPVEIAEAVFNYGDFTTMLTGIAPDQVTRMITGVPWYSSRLKPAISSALSKDGIYTIAN
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization:
Chromosome. Membrane. Nucleus.
Sequence:
MRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYCEHAKRKTVMNSHQFRILVGQIAIAFLFLFLFFSLPHSFTSTGLNISVEINDLIDIQCPQTENTTEGRLKAQYLKFMQVSYQGYEQCSLSARNRHLLSCNRPYVQNRLTLLFQEHTPYPRGPTFRHGEEYYFITTSNGSANGIDNSRGGLCESHYMKLRVYVKPKPTASPTTGGPPTTPSNSSTPPDISRAATSMTSRTTTRATTTLRTTSLPPTTTRRTTRYTTGGKIKSTEEGNNIPDNMTRGAANRRHVSTTLLLASLLVAVVRWLHP
The following text describes a protein:
Function:
May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.
Subcellular Localization:
Nucleus.
Sequence:
MVINLCLPQFRPRIHCNKISADGYEVENLISEDLTKRSHGFRTEYFIKPPVYVTVSFPFNVEICRINIDLTAGGGQNVTGLEMYTSASSSRVSWNTPQCRTLGPAEPSVPDKEAFTLVGKVLLKNQSQVVFSHRGFKARPPFGPMEATLPSPAVVAQELWNKGALSLSHVAHLRICITHVTGGGIPCIKRLEVWGQPAKTCSQEVIDSILLVASESLPQDVALQAPALPMESDCDPGDQPESQQAPSSLQKLAEIIQDVPEEFLDPITLEIMPCPMLLPSGKVIDQSTLEKCNRSEATWGRVPSDPFTGVAFTPHSQPLPHPSLKARIDHFLLQHSIPGCHLLGRAQTALAVIPSSIVLPSQKRKIEQAEHVPDSNFGINASCFSATSPLVLPTTSEHTAKKMKATNEPSLTHMDCSTGPLSHEQKLSQSLEIALASTLGSMPSFTARLTRGQLQHLGTRGSNTSWRPGTGSEQPGSIPGPACASCKRVFSPYFKKEPVYQLPCGHLLCRPCLGEKQRSLPMTCTACQRPVASQDVLRVHF
The following text describes a protein:
Function:
Gibberellin-regulated protein that may function in hormonal controlled steps of development such as seed germination, flowering and seed maturation.
Subcellular Localization:
Secreted.
Sequence:
MAKLITSFLLLTILFTFVCLTMSKEAEYHPESYGPGSLKSYQCGGQCTRRCSNTKYHKPCMFFCQKCCAKCLCVPPGTYGNKQVCPCYNNWKTQQGGPKCP
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Sequence:
MESWRVYSIWMGFLQVPTCLGEQIHIHQYGDLSDSCDSAGGHYNPFKVNHPSHPGDFGNFYSKEGKIIKYKANLVATLFGPYTIMGRSVVVHVQEDDLGKGNNKASLENGNAGKRLACCVIGTSQVGVCTLFLF
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. ATP5MK is a minor subunit of the mitochondrial membrane ATP synthase required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria.
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MSDHFNFNEAFNSQTMRGRANVAKATWASLGLVYVLVKMHRRNTKRRETKLYCKGCQQAMLHG
The following text describes a protein:
Function:
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Subcellular Localization:
Cytoplasm. Secreted.
Sequence:
MAETPGTGAAFGGRRALPPNTSNAEENDPPTVELQGGLMPRGFNPQDYLNVTDVHLFKERWDSNKVDHHTDKYDSKKLIVRRGQPFYIQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPVPIVSELQRGKWGAKVITTEDRSVRLSVQPSPDCIVGKFRMYVAVWTPYGVIRTSRNPETDTYILFNPWCEEDAVYLDNDKEREEYVLNDIGVIFYGEFNDIKSRSWSYGQFEEGILDACLYMMDRAKMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNVYSYGVPPSAWTGSVDILLEYKSSQTPVRYGQCWVFAGVFNTFLRCLGIPARVVTNYFSAHDNNANLQLDIFLEEDGNVNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQVVDSTPQENSDGMYRCGPASVQAIKHGHVCFQFDAPFVFAEVNSDVIYITAKKDGTHVVKTLDTTHIGKLIVTKQVGADGMKDITDTYKFQEGQEEERLALETALMYGAKKPLSTEGIPKSRSDIHMDFEVERAVLGRDFKVVLTFRNNSPTRYSVTAYLSGNITFYTGVSKGEFKNETFNVTLEPLSFKTEAVWVRAGEYMGQLLEQAFLHFFVTARVNETNDVLAKQKSVVLTIPKISVKVRGTQAVGSDMVVTVEFTNPLNEPLQNVWMRLDGPGVTRPLRKIFREIRPNATVQWEEVCRPWVSGPRKLMASMTSDSLRHVYGELNLHIQRRPSV
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MTLEEKEEVSTSTSQSPQSSSFENVFCAICGDRATGKHYGAMSCDGCKGFFRRTIRKRHSYVCRFGEKCQVDKAKRNSCRKCRFDVCLRKGMRRDAVQTERDRIRPANPLSNGSNGGIVPDDPLLDTLIRAEASTRGLRTTVITKTAEARKQATTNDVTDSMNQQLTLMVEWAKVLEGFQRVDNITQVALLRHFSAQHLVMCAAFRSIHLSDAVWLTNETCLHKDSPKIPDMNRVAERIIDQVTNPMRSLHMNEIEYIALKAIAFFDPLAKGITSESYSDVEEMRQRILESFERHVRYVSPYKDMPLRFANLLLLLPPMLAISRDLVEDVQLAKLFGLASIDNLMLELMLPNEGKNTTDKTSPPIMCHQ
The following text describes a protein:
Function:
Binds to direct repeats of the sequence 5'-AGGTCA-3'. Inhibits the ecdysone response. Plays an essential role in regulating molting of the tracheal cuticle during larval development.
Miscellaneous:
MISCELLANEOUS: [Isoform A]: May be due to a competing acceptor splice site.
Subcellular Localization:
Nucleus.
Sequence:
MDGVKVETFIKSEENRAMPLIGGGSASGGTPLPGGGVGMGAGASATLSVELCLVCGDRASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGAMNCEVTKHHRNRCQFCRLQKCLASGMRSDSVQHERKPIVDRKEGIIAAAGSSSTSGGGNGSSTYLSGKSGYQQGRGKGHSVKAESAATPPVHSAPATAFNLNENIFPMGLNFAELTQTLMFATQQQQQQQQQHQQSGSYSPDIPKADPEDDEDDSMDNSSTLCLQLLANSASNNNSQHLNFNAGEVPTALPTTSTMGLIQSSLDMRVIHKGLQILQPIQNQLERNGNLSVKPECDSEAEDSGTEDAVDAELEHMELDFECGGNRSGGSDFAINEAVFEQDLLTDVQCAFHVQPPTLVHSYLNIHYVCETGSRIIFLTIHTLRKVPVFEQLEAHTQVKLLRGVWPALMAIALAQCQGQLSVPTIIGQFIQSTRQLADIDKIEPLKISKMANLTRTLHDFVQELQSLDVTDMEFGLLRLILLFNPTLLQQRKERSLRGYVRRVQLYALSSLRRQGGIGGGEERFNVLVARLLPLSSLDAEAMEELFFANLVGQMQMDALIPFILMTSNTSGL
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for glutamine; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MSSGNMLAIFYFLLEGIGNTLLVTFTCFLSAFLTGLTVAVLRRLSPLPLQKILDVLVFILRGIPILIAVFLVYFGLPSIGIYVSPLVAMNLSVGLISGSYLAEVFRGALKLVEPFEITVAKVAGMRQLQVIINIELPQMLRFSVPGIINEFSSVLKATPFAYTVGIAEITKQAMSLTAITLNGLQIYTLAGVLYFIIYKVFTLLAGVFEKKYRIS
The following text describes a protein:
Function:
Acts in a signal transduction pathway that regulates the slug versus culmination choice. Believed to be the first component of a phosphorelay that couples the sensing of ammonia to the modulation of PKA activity and hence activates culmination and spore germination. Ammonium transporters amtA and amtC are thought to respectively activate and inhibit dhkC phosphorelay. This protein probably undergoes an ATP-dependent autophosphorylation at conserved His residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MIVEVELGFLLSTLFFTIISIILFYFFINNKNNLIDQCQEVTKLNNKDNKIVNNNNNNYNNNNFNKIEEINDDKNKEIIKLINNSNNKNLKIKIQEIDSGNNNNNNNNNNNNNNNNLNKNSNEIFRNFKIFSGSLLVIDQDLNIISSSESVRDIFSNINDINGVNQQVIGSLQNYSFINLVHQKDKDRVSTFLKLKFKNNNNIKHQQFSEDIINEKDELKEIQIEDNKELIIINNNNNNNNDNVLKFGNNNSNNSSIILFQGVYHLNNTDLSKPFNLQVSILPFISENYIVLSLKDLSPPPLRLLLNKTSSALSPRSLSSSSSSSPSSSNNNGNTNNSGSLSPRSSNSNGSAVSPRNVSSNSMSPRGQNSDRSISSPRGSSSSSSSSSNELAISPRNSNGTISSPRTSNLSIESVLNNKSIDMISHLSHELRTPIHSVIASIQLFRSTILTVTQNEYLSIIDTSANTLLELVSNVLDYKRIRSGKLTLNNVDFNLCHVIEDVCAMVSPQAQAKSLQIASFIFIHCPLSFYGDPIRLRQVLLNLIGNGLKYTNKGQVCISVEPEQVNEHCMYLHFQVKDSGIGIKEENMSKLFAGFSQVNNGGTTQEALGSGLGLAISKDLVELMGGKIWCSSNATQNNGEAGCTFHFVIPLETNPKQLPCPIQNFNGLSVLVVDKNPYIQTVLCQYLEGWNCQVIKSSDIKEASNKLKDLRREQIEVVMIDIDNIDFRDFIQFKDAFNRLEFGRIGLITMSSDRSMVNEMGFGTSKLTKPFRQSHLVACLLASMPEHSSSTTNCFSNIVGMNSNINNNNNINNNSNNNNNNMQTHNSNSVYGNGNYGNCTPFSNNNNRIHMMSSGDKPSINNRRMSISLGKIPTFNSGGSNSPRSKKLFEEVLQQQQLQQQLQQQLQQQQQLQQQQQQQQQQQQQQQQQLQQQQQQLNTIDDDSNNYCNTTGTMDSIDEINKNNYSDSESDELNDDQAPIIAPVQQLSFGRVTRRHSIDIIMFENSRELSELRNLEDSTRYLSPRSMNNNNGNNDNGINGGSGNSLFGSSIKEEIGGTSDTSSLAQSPNSLSPRAPTKIMILDDNPVSLKLMQRILESRGFECYPFDCSEKAVAQLDQVNPAIIFMDCEMPKMNGFECTQLIRKREQESLCLLKDRKIIIALTAHINPEIQVKCFDAGMNDFISKPFKPQCLELILRKWEDCISNNQLNYNNSLINNQTTIQEQV
The following text describes a protein:
Function:
Sugar proton-coupled antiporter which contributes to vacuolar sugar import (e.g. monosaccharides including glucose, sucrose and fructose), particularly during stress responses (e.g. in response to cold).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MSGAVLVAIAAAVGNLLQGWDNATIAGAVLYIKKEFNLESNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSLMPSPSWRLMLGVLFIPSLVFFFLTVFFLPESPRWLVSKGRMLEAKRVLQRLRGREDVSGEMALLVEGLGIGGETTIEEYIIGPADEVTDDHDIAVDKDQIKLYGAEEGLSWVARPVKGGSTMSVLSRHGSTMSRRQGSLIDPLVTLFGSVHEKMPDTGSMRSALFPHFGSMFSVGGNQPRHEDWDEENLVGEGEDYPSDHGDDSEDDLHSPLISRQTTSMEKDMPHTAHGTLSTFRHGSQVQGAQGEGAGSMGIGGGWQVAWKWTEREDESGQKEEGFPGSRRGSIVSLPGGDGTGEADFVQASALVSQPALYSKDLLKEHTIGPAMVHPSETTKGSIWHDLHDPGVKRALVVGVGLQILQQFSGINGVLYYTPQILEQAGVGILLSNMGISSSSASLLISALTTFVMLPAIAVAMRLMDLSGRRTLLLTTIPILIASLLVLVISNLVHMNSIVHAVLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIAICALTFWICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETKGMPLEVITEFFSVGARQAEAAKNE
The following text describes a protein:
Function:
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis. Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling (By similarity). In response to TNF and in parallel to NF-kappa-B activation, negatively regulates RANTES induction through p38 MAPK signaling pathway (By similarity). Involved in endocytic membrane trafficking induced by sphingosine, recruited to dilate endosomes, also plays a role on later stages of endosomal maturation and membrane fusion independently of its kinase activity. In Purkinje cells, seems to be also involved in the regulation of autophagosome-lysosome fusion upon VEGFA; Has serine acetyltransferase activity on PTGS2/COX2 in an acetyl-CoA dependent manner. The acetyltransferase activity increases in presence of the kinase substrate, sphingosine. During neuroinflammation, through PTGS2 acetylation, promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus. Cell membrane. Synapse. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner. Binds to membranes containing negatively charged lipids but not neutral lipids (By similarity). Recruited to endocytic membranes by sphingosine where promotes membrane fusion.
Sequence:
MEPVECPRGLLPRPCRVLVLLNPQGGKGKALQLFQSRVQPFLEEAEITFKLILTERKNHARELVCAEELGHWDALAVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPGGSGNALAASVNHYAGYEQVTNEDLLINCTLLLCRRRLSPMNLLSLHTASGLRLYSVLSLSWGFVADVDLESEKYRRLGEIRFTVGTFFRLASLRIYQGQLAYLPVGTVASKRPASTLVQKGPVDTHLVPLEEPVPSHWTVVPEQDFVLVLVLLHTHLSSELFAAPMGRCEAGVMHLFYVRAGVSRAALLRLFLAMQKGKHMELDCPYLVHVPVVAFRLEPRSQRGVFSVDGELMVCEAVQGQVHPNYLWMVCGSRDAPSGRDSRRGPPPEEP
The following text describes a protein:
Function:
Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1 (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MKVSVAALSCLMLVTALGSQAQVTNDAETGFMMSKLSLANSEVLDSFHAINADCCTSYIPGSIPCSLLESYLETSSKCPKPGVIFLTKNGRRLCVSPSNKQVLACRIMLKLATRIKTRKN
The following text describes a protein:
Function:
Could possibly oxidize fatty acids using specific components.
Sequence:
MPTPDFQTLLYTTAGPVATITLNRPEQLNTIVPPMPDEIEAAIGLAERDQDIKVIVLRGAGRAFSGGYDFGGGFQHWGDAMMTDGRWDPGKDFAMVTARETGPTQKFMAIWRASKPVIAQVHGWCVGGASDYALCADIVIASEDAVIGTPYSRMWGAYLTGMWLYRLSLAKVKWHSLTGRPLTGVQAAEAELINEAVPFERLEARVAEIATELARIPLSQLQAQKLIVNQAYENMGLASTQLLGGILDGLMRNTPDALEFIRTAQTQGVRAAVERRDGPFGDYSQAPPELRPDPTHVITPDGSM
The following text describes a protein:
Function:
Degrades free oligosaccharides in the vacuole.
Sequence:
MSSDIVNWDPQFKPVKGIYEDRLRQFIDNGGDYRDLNLPKFYDRQRKRIDSTRVKVQYYQVPYDRHKPPVAPEKRPPWEEVVRRDRAGEIEWKDVYLGQPFGPSWSTTWFKVELDIPESWSSSGEQLVFEWDCENEGIVIDGDTLLPKTAFSGNGERTEYLLPLGRSSVSFYIECGNNGMFGVGRNNNSINPPDDDRYFHLQKADLVWPNWQARALYIDFWMLGDAARELPDNSWQKHRARELGNLVMNMFDPEDVSTVDKCRKFLQKEFFDKYTDDPKVYQQGDPQVRANVYAMGNCHIDTAWLWPFAETKRKIVRSWTSQCTLMDEFPEYQFVASQGQQFKWLLEQHPRFFKEVLVPRVQQAQFFPIGGSWVENDTNIPNGESLCRQFFYGQRFFMKHFGLKSDIFWLPDTFGYSSQVPQICRISGITKFLTQKLSWNNINSFPHSTFNWSGIDGSMVLTHMPPGNTYTASSHFGDVLRSANQNKSNEHYGTGLMLYGYGDGGGGPTREMLNKMRRIRSMSNRNGNVVPKLEVGKSVNEFYDDIMQKTDNGNALATWTGELYFEFHRGTYTTQADVKRLMRLSEVKIHDLEWIATKVSLLAPNKYTYPVNDINALWEDILLCQFHDVLPGTCIEMVYKYEAIPMLNKVVQLADRFIERALEALNTGGESLVPIGTLQWDNMAAENADAQESVFYPASVSKDSETIILNNKKLQVTFEKNTGVIKSIKDLFHDLEFIDTKHGRNKIGANQFVLFDDQPLFWQAWDTELYSVNKYQYLQNVESVTVVQDCKDVCSVETRVSIAPGSTIISTVSLSSLTSETLDDAKVDIVTKVINWNQRNKFLKVEFPVSIFNDFASYETQYGITRRPTHYNTSWDVAKFEVCQHKFTDYSDYTKGVSVLNDSKYGFSTHGNLMRLSLLRSSKAPDENADMGTHKMRYAIYPHKGGLTTDTVRLGLEFNYSYKYGVHEGLAKDFRDIISITGDKNVILANLKRGEDDEALKSDYSMAPKPESSIVVRVYESLGGESVASLLTSLKVKKVLKVNSLELDTVESLAFKTPDESTHRKFEIPIKLRQFEIATYKIMF
The following text describes a protein:
Function:
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
Subcellular Localization:
Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope.
Sequence:
MSYPVTSQPQCANTCYQTQLSDWHTGLTDCCNDMPVCLCGTFAPLCLACRISDDFGECCCAPYLPGGLHSLRTGMRERYHIQGSVGHDWAALTFCLPCALCQMARELKIRE
The following text describes a protein:
Function:
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
Sequence:
MLPLPSELQIQAQSIKQRFSELPAPPDLRDEDIAVLALSDFVSDMLLIHPQWLEELHQQPPQPQEWQYYSQWLSQALAGVQDEAALLTALRLFRRRVMVRIAWSQVLQTSGTAETLQQLSTLAESMIIAARDWLYQVCCRELGTPCNRQGVPQPLLILGMGKLGGGELNFSSDIDLIFAYPENGQTQGGRRELDNAQFFTRLGQRLIKALDQHTIDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGGADDPYSQELRQMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFITQVFQLIRGGREPRLQERALLPTLQAVAELGLLPEQQVADLSGSYLFLRRLENLLQAIADEQTQTLPNDPLNQARLAWGMGYADWAAMSTALENHMQAVRVVFDDLIGDETPDIGEDPSHGLYKSLWQDVLEESDLAPLTPHLEEAARRQLLATISGFRHDVDKRTIGPRGREVLDQLMPRLFAEVCPRPDANVALSRLILLLLSIVTRTTYLELLVEYHAALKHVIRLCSASPMVASQLARYPLLLDELLDPQSLYQPLAPSAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQQLRIAAGDITEALPVMKVSDHLTYLAEAIIDAVIQQAWNQMVARYGQPSHLQQSEGRGFAVIGYGKLGGWELGYSSDLDLVFLLDCPLDVMTDGDRSIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGEAGMLVSTIEAFADYQRNEAWTWEHQALVRARIVYGSPKLHQQFDAIRQQILCRHREDPQLQQEVREMREKMRNHLGSKQRDIFDIKADAGGITDIEFIAQYLVLRYAASEPRLTRWSDNVRIFESMAHYDIMSPEEAAALTRAYVTMRDEIHHLALQEQSSKVAADSFIAEREQVAASWHKWLAANDANVS
The following text describes a protein:
Function:
Involved in basal (BT) and acquired thermotolerance (AT), probably by preventing plasma membrane lipids peroxidation induced by severe heat-shock (HS). Lipocalin that confers protection against oxidative stress caused by heat, freezing, paraquat and light. Confers resistance to high salt (NaCl) levels, probably by protecting chloroplasts from ion toxicity via ion homeostasis maintenance. Required for seed longevity by ensuring polyunsaturated lipids integrity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Plastid, chloroplast membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocates from cell membrane to cytoplasm upon salinity stress. A small fraction is associated with the chloroplast envelope.
Domain:
The HPR motif (90-97) is required for intracellular targeting at membranes.
Sequence:
MTEKKEMEVVKGLNVERYMGRWYEIASFPSRFQPKNGVDTRATYTLNPDGTIHVLNETWSNGKRGFIEGSAYKADPKSDEAKLKVKFYVPPFLPIIPVTGDYWVLYIDPDYQHALIGQPSRSYLWILSRTAQMEEETYKQLVEKAVEEGYDISKLHKTPQSDTPPESNTAPEDSKGVWWFKSLFGK
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNNLKLYSELSSKLELESKEEDESVLLSAFDIEQSRLFFASSANRIYTTHLSSFHNERAWSLSADVDSIDLEPNDYITALEYLMEKEALVIGTFDGLLLLHGVDGNETTMVGRVEGGVRCISPSPDGDVLAVISRLGQIMVMTHDWDLLYETALEVVPEGVDVREPTYSRYESPISWRGDGKYFVTLSEVCDSITLLKRIKVWERDSGALHATSESKAFMGSVIEWMPSGAKIAAVCDRKTDNECPSIVFFERNGLERSSFSINEQIDSTIDILRWNCTSDLLAAIVRCEKHDAVKIWLFSNNHWYLKHEIRYSKKDGVKFMWDPTKPMQLICWTLGGHITLYNFVWNTAVTENSISLVVDDSKIFVTPLALSLMPPPMYLFNLKFPTAVREISLYSKNTKNCLAAFLSDGCLCVVELPTVDTWDELEGKQFIVEASISESVFGSIVHLIWLDSHILLAVSRYGFDHYLSKTSSNEDGLLGFYLQEIELSCSEDHVPGLLTCSGWHAKISHQNSLEGQVIGIAPNPTKRCSAYIQFDGGKIFEYTSRIGALKHNDLSFLSSCPWMSVVSVVDGGSLKPLLFGLNDIGRLSVGGRILCSNCSSFSLYSNLADQVITHLILATKQDLLYIVGINDILHGKLEMYEDFIHTGNRRREEIKTFINIWERSAKIVGVLHGDEAAIILQTTRGNMECIYPRKLVLASIVNALVQERFRDALLMVRRHRIDFNVIVDHCGWQAFLQSAAEFVRQTNNLSHITEFVCAINNENVTEGLYGDIISLPCSKDIKDLKARDPKGLDVNNKGSSVLLAIRKALEEQLPESPARELCILTTLARSDPPLLEEALARIKVTREMELSSSNDPKRRSYPSAEEALKHLLWLSDSEAVFEAALGLYDLNLAAIVALNSQRDPKEFLPFLQELEHMPVLLMRYNIDLRLRRYANALKHIVSAGDAHYDDFMNLMKKNPQLFPLGLQLINDPAKRKQVLEAWGDHLSGEKCFEDAAITYLCCFSLEKALKSYRACGNWSGVLTVAGLLEMGKDEVMQLARELSEELQALGKPGEAAKIALEYCGDVNEGINLLISARDWEEALRVAFLHRREDLILEVKNASLECASMLIGEYEESLEKVGKYLARYLAVRQRRLLLAAKLQTEERSTSDLDDDTASEASSNFSGMSAYTTRTRKTTTSSIISSAASKARDMRQQRKRGKIRPGSPGEEMALVEHLKGMALTAGAKHELKSLLGSLVMTSEETTARKLQHTAENFQISQMAAVQLAEDAMPSDNINEQAHTLELYIQRVKSEAQNSEAFFWRSKIFLSP