lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level. Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH.
Subcellular Localization:
Nucleus.
Sequence:
MGPNYCFLLLLQVPRTLNPAPRSESTQAPARLWGAEMAAPFSGSEVKCVSVEWDFLQGLLVKAPPVPCLQALRKEKSRNAARSRRGKENFEFYELAKTLPLPSAITSQLDKASIVRLSITYLRLRDFAALGDPPWTPPRADLSPAPVSGAPGRRESSAFLTDLFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHSEVLEQLGLKAPPPGPGAPLYGPSSSSSSSSASSNSEAPETELGPPVLTPRNQPGLLDRSFFIRMKSTLTKRGLHLKASGYKVIHVTGRLRTQLLTTRRGQVLGLVALGHTLPPAPLSELPLHGHTLVFRLSLALTIISCESRISDYMDVGPSELIGRSCYQFIHGEDVAGVRQSHLDLLDKGQVVTGYYRWLQRAGGFVWLQSVATVAISGKSPGERHVVWVSYILSQVESSHVVLDAFQLPRTGPQEDLSDPEPEIKEPKAQVEGEPGAPQPESGARHPRGKRIKLEPARGGGGGGRSSSSSSSSSSQGEAPGGGGEGGDDSDEEEPSLPAPRPEFTSVIRAGSLKREGLRPWSFAASYPAREPFHRPPSPPDSPSPPALVHAGYLAPGRGLYTSTIRYGPAELGLALPSPGLVYQHLQRLSGPGPAFPDTLYPSVPFLGPDRKGD
The following text describes a protein:
Function:
O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MVARSVARLHSAATTAAASASASNELARFARLAHEWSDEKGAFRALHSMNELRVPWIVEETTKGVPLPAEAARAPQVLDVGCGGGILSMALARRGLRVRGVDACVESIDVAKKMAEQAVIPPAVRARLQFDVVEETALGEGKECGAYDAVVASEVVEHVPSVPAFVRSLVAAAKPGAPIFLTTINRTTLSRVAAIWLAEEVLRVVPSGMHDWRQFVKPEELTAELEANGCKVHQVLGMDYNPLLDRWKWTECTQINYAVLARRIL
The following text describes a protein:
Function:
Involved in post-transcriptional regulation of gene expression by 3'-UTR-mediated RNA regulation. Promotes interactions between mRNA and poly(A)-binding protein. Binds the 3' UTR of mRNAs, centromeric transcripts and antisense-rDNA. Required for the establishment but not the maintenance of heterochromatin at pericentromeres, and for the maintenance of small domains of facultative heterochromatin known as HOODs.
Sequence:
MTIRSLNLFIIDKKHQHKSSLSSFQNCKLGIDASFYLTQIIHSFTPQELQSLAVNGESEYLQHRISEFLEQLRTENITPIFVFNGIPLTFEASSQLEVPGKQKSHSALTDFEAFDPYDANIQRNMYRMDASGPANYGESKPTLLYTNQRDHLDRLCDQVKFYLDQCNVEYFVAPYLAMAQLAYFLNGTSSPYIDAIYGSTDLLLFGVKKFITSMNTSSNVKISSDPSSPSTQTTINSAAKSSFTWLDGNALLQDTNGLSWQQFIDSCLLCGTAISPTFPQIEGTFLIKSAMELVRMFGSAYRAVLHFAEIFPQPIFQDYLQQYKRAVCFSKFGIVMDTKGLTLPPVPTESVPNDINIYFGTRLPNEIYFYISRGLIPCKMIGALVSGCFSDPVSILEQHIGDKASQGTFSGANSGLNPGRDNAAAVAAVDQRRFVDDLEEIWSQGLNLLTQPLNRFYQARDIVSLHGHNQQASLKVMHSYDPPLYNDTRAWMIYEENLPSYLSSNFLKEEPVVLFDLLRALNDPVFVKKSFCTEGNIGIKNPPKHPLSSTAEIVLSSCYRFLQIRSFVLTSHQLTSWGCPLLKALENCHLQNQTSVVVLFELLRLRQLKEPSLLSSSSASIADLSITSATEFLAKVATFLPIKQRPEVSKISIVDENLLQFYQLQTSFGSNLKELMAMILASVILNRNVDKSKIDPKLIRKTLPFQNINGSLVSGFVVKRFFEIISKEQEASSQQENIQKAYEIIEKEFPTIGSAENHIAQFLEFWKTFMEGVKEAENTSAIGKLVLSKLFLTNQWIFSLGL
The following text describes a protein:
Function:
Required for the establishment of the bipolar budding pattern. Involved in selecting bud sites at both the distal and proximal poles of daughter cells as well as near previously used division sites on mother cells. The RAX1-RAX2 complex performs the asymmetric localization of the two cortical landmarks, BUD8 and BUD9, at the distal and proximal poles, respectively.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Bud neck. Bud tip. Note=Before cytokinesis, RAX1 concentrates as a ring at the mother-bud neck and to the tip of the bud. The RAX1 ring splits at cytokinesis, endowing each progeny cell with a RAX1 ring and additional RAX1 localization at the distal bud pole of the newborn daughter cell. The rings persist at the cell cortex for several generations, giving rise to cells decorated by multiple rings.
Sequence:
MKEELSKVSSMQNFEMIQRERLPTLYEVLIQRTSQPVDLWTFYTFLSQFPYAINYLDFWVDLMTHTRLCKNYIELVRKSLINFPQEQQQNGSTSTATFDLLNALIEEGHLDPEAPDKLLENSGPDVPFSPKLNELLGDWKHQSGIGQEALRNEDVALIVDEIMKRRSQQDGKPQITTKQLLHSAVGLCNTYLVSPEQSERYLSNIPMETRNRIIESVQIERKYDIEIFDDLKNLTYQFLEMDCFPKFLSRVALHNIHDEISDWRFHSVGVTNEKSNRSRGQTHISRSPFSNHTSISRIGFGLLWLGIGFWIGYVLIFLAYSRAIRVVTVVPFTLGCYCIVCGMYQVDIVYSWFGVTQRLLHRHKNAGNDEGDASSDTDHVPMILAVFGGRRRLTRIEHPFTRQLLRKRGLWCLLLVVGATAAFTVIFSCVPGRRV
The following text describes a protein:
Function:
Receptor for an extracellular signal required to instruct a cell to differentiate into an R7 photoreceptor. The ligand for sev is the boss (bride of sevenless) protein on the surface of the neighboring R8 cell.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Domain:
It is unclear whether the potential membrane spanning region near the N-terminus is present as a transmembrane domain in the native protein or serves as a cleaved signal sequence.
Sequence:
MTMFWQQNVDHQSDEQDKQAKGAAPTKRLNISFNVKIAVNVNTKMTTTHINQQAPGTSSSSSNSQNASPSKIVVRQQSSSFDLRQQLARLGRQLASGQDGHGGISTILIINLLLLILLSICCDVCRSHNYTVHQSPEPVSKDQMRLLRPKLDSDVVEKVAIWHKHAAAAPPSIVEGIAISSRPQSTMAHHPDDRDRDRDPSEEQHGVDERMVLERVTRDCVQRCIVEEDLFLDEFGIQCEKADNGEKCYKTRCTKGCAQWYRALKELESCQEACLSLQFYPYDMPCIGACEMAQRDYWHLQRLAISHLVERTQPQLERAPRADGQSTPLTIRWAMHFPEHYLASRPFNIQYQFVDHHGEELDLEQEDQDASGETGSSAWFNLADYDCDEYYVCEILEALIPYTQYRFRFELPFGENRDEVLYSPATPAYQTPPEGAPISAPVIEHLMGLDDSHLAVHWHPGRFTNGPIEGYRLRLSSSEGNATSEQLVPAGRGSYIFSQLQAGTNYTLALSMINKQGEGPVAKGFVQTHSARNEKPAKDLTESVLLVGRRAVMWQSLEPAGENSMIYQSQEELADIAWSKREQQLWLLNVHGELRSLKFESGQMVSPAQQLKLDLGNISSGRWVPRRLSFDWLHHRLYFAMESPERNQSSFQIISTDLLGESAQKVGESFDLPVEQLEVDALNGWIFWRNEESLWRQDLHGRMIHRLLRIRQPGWFLVQPQHFIIHLMLPQEGKFLEISYDGGFKHPLPLPPPSNGAGNGPASSHWQSFALLGRSLLLPDSGQLILVEQQGQAASPSASWPLKNLPDCWAVILLVPESQPLTSAGGKPHSLKALLGAQAAKISWKEPERNPYQSADAARSWSYELEVLDVASQSAFSIRNIRGPIFGLQRLQPDNLYQLRVRAINVDGEPGEWTEPLAARTWPLGPHRLRWASRQGSVIHTNELGEGLEVQQEQLERLPGPMTMVNESVGYYVTGDGLLHCINLVHSQWGCPISEPLQHVGSVTYDWRGGRVYWTDLARNCVVRMDPWSGSRELLPVFEANFLALDPRQGHLYYATSSQLSRHGSTPDEAVTYYRVNGLEGSIASFVLDTQQDQLFWLVKGSGALRLYRAPLTAGGDSLQMIQQIKGVFQAVPDSLQLLRPLGALLWLERSGRRARLVRLAAPLDVMELPTPDQASPASALQLLDPQPLPPRDEGVIPMTVLPDSVRLDDGHWDDFHVRWQPSTSGGNHSVSYRLLLEFGQRLQTLDLSTPFARLTQLPQAQLQLKISITPRTAWRSGDTTRVQLTTPPVAPSQPRRLRVFVERLATALQEANVSAVLRWDAPEQGQEAPMQALEYHISCWVGSELHEELRLNQSALEARVEHLQPDQTYHFQVEARVAATGAAAGAASHALHVAPEVQAVPRVLYANAEFIGELDLDTRNRRRLVHTASPVEHLVGIEGEQRLLWVNEHVELLTHVPGSAPAKLARMRAEVLALAVDWIQRIVYWAELDATAPQAAIIYRLDLCNFEGKILQGERVWSTPRGRLLKDLVALPQAQSLIWLEYEQGSPRNGSLRGRNLTDGSELEWATVQPLIRLHAGSLEPGSETLNLVDNQGKLCVYDVARQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNCLLLPSSGGSLLKATDCEEQRCLLNLPMITASEDCPLPIPGVRYQLNLTLARGPGSEEHDHGVEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASATPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADTVVSCSRPEFKVRFDGQPLEEHREHNERPEDENLTLREVPLKDKQLYANEGVSRL
The following text describes a protein:
Function:
Acts as a co-chaperone with Hsp70 required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity). Acts by determining Hsp70's ATPase and polypeptide-binding activities (By similarity). Can also act as a chaperone that promotes maturation of potassium channel unc-103 by stabilizing nascent channel subunits and assembling them into tetramers.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MTADANKSESLLCMDKAREAIKSGDTDKARRMLLKAKKLDPGQNIEFLTKKIDDMTNNTSSSSQTSSSRASEERSYAHDDHYDDPNLRNRKARSPVKKNGKTEPEPKQRSASRTPKLGVDYTSEQKELVERIRHCKDYYEILKIDKKASDDDIRKEYRKLALKLHPDKCRAPHATEAFKALGNAYAVLSDTDKRRQYDQYGAEAANSHTPTTRRRGGGHGAFFEHDYAHGFEAEFTPEEIFNMFFGGGFPTEQVRRRARYAQQQQYHHYEQQQSPYGPLLQLLPLIAIMVIGLLAQLMVGEPAYSLHQTSKFTIKRLTADLRVPYFVRTDFETSYRGRIRQVEQQVEDDYIQNLRMNCYKEQNLKETKLYRARWMRDEAMMRDAERTPLPSCIRLNEIYSH
The following text describes a protein:
Function:
Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation.
Subcellular Localization:
Nucleus.
Domain:
The C-terminal portion of EID2B is required for nuclear localization.
Sequence:
MAEPTGLLEMSELPGDSSVPQVGTASGVSDVLRGAVGGGVRVQEAREGPVAEAARSMARMPGPVPGPIPSSVPGLASAPDPHQQLAFLEINRQLLFREYLDGSSMIPVRLLRDFEERRRLFVEGCKAREAAFDADPPQMDFAAVAFTVALTASEALSPLAD
The following text describes a protein:
Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).
Domain:
PTB domain mediates receptor interaction.
Sequence:
MGDGAVKQGFLYLQQQQTFGKKWRRFGASLYGGSDCALARLELQEGPEKPRRCEAARKVIRLSDCLRVAEAGGEASSPRDTSAFFLETKERLYLLAAPAAERGDWVQAICLLAFPGQRKELSGPEGKQSRPCMEENELYSSAVTVGPHKEFAVTMRPTEASERCHLRGSYTLRAGESALELWGGPEPGTQLYDWPYRFLRRFGRDKVTFSFEAGRRCVSGEGNFEFETRQGNEIFLALEEAISAQKNAAPATPQPQPATIPASLPRPDSPYSRPHDSLPPPSPTTPVPAPRPRGQEGEYAVPFDAVARSLGKNFRGILAVPPQLLADPLYDSIEETLPPRPDHIYDEPEGVAALSLYDSPQEPRGEAWRRQATADRDPAGLQHVQPAGQDFSASGWQPGTEYDNVVLKKGPK
The following text describes a protein:
Function:
May function as somatic storage protein during early seedling development.
Sequence:
MARSLLLSLTLTFLFAGIVSARDWNILSQLKGTTTTTKTSQTGVTSLKAPNLNGYCESWRVNVELNNIRDFKVVPQECVWFVQKYMTSSQYEDDVERAVDEAILYLGKTCCEKKTCDGMDAWIFDIDDTLLSTIPYHKSNGCFGGEQLNTTKFEEWQNSGKAPAVPHMVKLYHEIRERGFKIFLISSRKEYLRSATVENLIEAGYHSWSNLLLRGEDDEKKSVSQYKADLRTWLTSLGYRVWGVMGAQWNSFSGCPVPKRTFKLPNSIYYVA
The following text describes a protein:
Function:
Acts as a phosphoinositide 3-phosphatase and regulates PtdIns(3,4,5)P3 levels.
Subcellular Localization:
Cytoplasmic vesicle.
Sequence:
MNILRSVVSRGRKGLKQEKVNRSFAYLDMVYITSKVIAMSTPAAGIHKLYRNDELDVFKYLTTQLKDNWILLNLCAEETVYHLELFKPNVINYGFQDHNPPPLLFLWAIVMNMDALFQTQPLLTLVVHCKAGKGRTGTVICSYLVAFGGLTAKQSLELYTEKRMVRGHGLTISSQIRYVYYIEILKQFPNYLKAVEFNTGTTFFKSFKCLNIKKNSSLILSLHAFSKGRNINPVALWKSSDISSHNVSIKEGKRIWGIQCNLETSEKDLLLRVERKGQFYFPSSVQCWFHTHFQPMLVEYTNGINFQQGINSFLQGQQSISFSWSEMDNSRRSDPFFEQLTIVYENVF
The following text describes a protein:
Function:
Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L. Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z. Also selectively represses protein production by associating with host eIF4E (By similarity). In cell-based minigenome assay, has an inhibitory effect on the ribonucleoprotein machinery (vRNP), which is responsible for the replication and transcription of the viral genome (By similarity).
Miscellaneous:
MISCELLANEOUS: Inhibition of host myristoylation by the compound DDD85646 leads to proteasomal degradation of protein Z (and not lysosomal), strong inhibition of Z-mediated assembly and budding, and reduced levels of viral replication and transcription.
Subcellular Localization:
Virion. Host cytoplasm, host perinuclear region. Host cell membrane; Lipid-anchor; Cytoplasmic side. Note=Mainly perinuclear. During budding, associates at the inner side of the plasma membrane of infected cells.
Domain:
Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins.
Sequence:
MGNKQAKAPESKDSPRASLIPDATHLGPQFCKSCWFENKGLVECNNHYLCLNCLTLLLSVSNRCPICKMPLPTKLRPSAAPTAPPTGAADSIRPPPYSP
The following text describes a protein:
Function:
Inhibits cell growth by regulating the Tor pathway upstream of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as a cell death activator during head development.
Subcellular Localization:
Cytoplasm.
Sequence:
MRQPETRRKSQVFMDSILTALKLQESENENESSQVISELDESTTDDKWWEEEAALRETPLINALQIQLETLLRQSTVFSFSFNETLTREIAEEVSRTSRQETGGMRACRVFVRLISESNFSSKVSHTETSLDKVSVNVGCLDLSAGETVSTFELYVYLCPSQSPLNWIRSVISAISSKTAPKQQRCRAVRLQLDFVLMKRKLFRSQDSSVKVFRQLSFKS
The following text describes a protein:
Function:
Probably involved in steroid hormones biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Sequence:
MLADSYLIKFVLRQLQVQQDGDAQHLLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTRFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECFRREEFTGRPDTPFMQTLNGYGIINSTGKLWKDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRRPLGPTAADPHHMRNVGAN
The following text describes a protein:
Function:
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAQNSRKKPNILVTGTPGTGKTTTSSLLADATQLRRINVGELVKEKNLHQGWDDEFDCHVIDEDLVCDELEDLVEEGGNIVDYHGCDFFPECWFDHVVVLQTDNSVSYDRLSNRGYMGSKLTNNIECENFQVLLEEAKASYPEEIVVAMQSNCVDDISNNVATLTDWVRSWHSAS
The following text describes a protein:
Function:
Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. Has ribonuclease activity.
Subcellular Localization:
Nucleus, PML body. Nucleus, nucleolus.
Sequence:
MFMERGDHDAGQDDFKVDEFTVPQESEKELRDQQPHVKRIFGVTLKIIGVLDQPQLGHCPMGHLQMWLEMRGDRRRIGKAKDYIKGLCTPEIKEDFDYPREMHCIFVGAKGLFLDCLIRATSAFVKPLAPGRIRISGLAEGAVMAQSWLCASVEKCKSNTKSNVHEVQIKRHFKDLVEDPTDKHALDLLILPTSVKEELLSLVGKHVDSTAKMESQDQQRMNENTNDITTFNHQFWPTEVQNTQKYEKITSSKVDVRNKSKAGNVILHHRASEPRHLATYNKWDCDSQEPPFPRLDTYERTIIQSTGIDVPQYQHMGERELLFHDDDEEFQQISGLLDTIMGRENGDQKHFSLGTQKEFNMLLDFFKTMGYQEAVVLKVLSENGIQEPSQILDKVKLEQSNTSQRTEQQNENVPHKGLSHTASSQNDEDDDDYVLEVVKSAARNCGYCPTEIVDIGNGSMAGLLRKLNEKNILEDDMVFSNCQSQDDTEGGQLFPDELRVEQVAELNAAEVNPPQMLKHNKHCNRPVEDLNPGVAQLEVGLLEKGQGPVDEKDPRVPVVTGVQRFNEAMQTPFQLNLRNEKGREELRYIIIDGSNVAMIHGLHRFFSCRGIALAVQYFWDRGHRGITVFVPQWRMKKDSKVKEQHFLTELNDLGLLSFTPSRTIEGKRVTSYDDRFMLQLAEKKDGVIVTNDNLRDIAAESQAWKAIIKDRLLQFTFVGDIFMVPDDPLGRNGPPLNQFLSKNSRPRTKSKGHSFAGRRGTHTAPKKSSQTEVLNFRDLKAGAVREKQKADVRSLNETQKLRRELLNIFPAQDSMVDYILHREPYLSDLNKLSELIITLEC
The following text describes a protein:
Function:
Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
Subcellular Localization:
Nucleus.
Sequence:
MAFEFDLEEFNDQLALFNLTCPDNEQIVEKLEELCKSFRKTSDDICNDIVSVMNNDGKTVIDRNILAKLEERFEAETKKVINTPRSMKKPVKSVRVPLSERSEFILSGGPGDDEKPHHMSNTAFTKLEGHFLEFSPFPNSPANEKFLKRSDPGLVVSAIRGRKFQDKGLKGGAKHDDKVKIVSKLPNNFYGGDKSSMVIDAKSTRMSEFARRLQATNEEIADWGNPLVPSVDFVYTYGQIVHDDTRDNEKFGENSVALMINDEDGTMIRLNFSKVTEDVTLFPGQIIAVRGTNETGEELQVDRIFTPKALPVNPVETDITKDIWFACGPYTAMDNCGYEHLCELLDQVVAEKPDILVLAGPFVDRKNTFLNKPNLTITYDNLMEDLLCKIKEKLVNTKTEVIIQPSSSRDLCTPSVFPSPAFRFKSRKLDMIKKELHFVPDPCIIRIGQNGVDMAVTSSEPIQGLSNSEFHRSINQENSDRIARLCSHLLTQQSLYPLEPTEIPSSLGDLLEVCQLTSTPHIVFAPTKLASSAKKVNGSVFINSSTLAKGPTGNYVKMSINLNAGELGPFETVADYANIQIMKI
The following text describes a protein:
Function:
Involved in DNA repair and RecF pathway recombination.
Sequence:
MEWTDEGIVLGVRRHGESSAIVELLTRAHGRHLGLVRGGAGSRMRPLLQPGNSVSAVWRARLDEHLGTYAVEGLKLRAATLLASSHGVYGVTHLASIARLLPERDPHEEIFGLLEHSLDDFDDIGSAAVHVIHFELAMLAELGFGLALDNCAVTGETTDLIYVSPKSGGAVSRGAGEPWRDRLLRLPPFLRHGETATELTDQDLQDGFRLTGLFLLRHVLEPRGQVHSDARAGFINALTRQQARAAIPAP
The following text describes a protein:
Function:
High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MDEEEHKDHQEEEDPHHFAFSDNYSEAVLGGEISATVFDVTGKVVHVAHKMTKYEFLLEHGLYPRDLRNIDPSPVSIIPSILARGRKGAGRCILVNLLHIKALILHDKVLIFDTHSKNKSDTHRLGMFLYELENKLKPTINPEKMHTDMTVLPFELRVLEAILVNVMTTLDGELQVHLKTLNEILVGLEDHVDREQLKELLIGNKNVSRFYQKAVLIRDVLEELLESDDDLQQLYLGTHPKEGLAEVELLIESYCKQADEIVQQASNVRSHIRSTEEIVNIIVDANRNALMLLELKVTIVTVGFAVGAFVAALYGMNLENFIEETNEGMVLVVGVACLGGLLVTWFNLTKLHKTQKIAMFSNAATHTASKPYMLQWIIGLLRRKRTKSRFDNIDMSRPKMKGKKSNILHQLTKMTGKRR
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The coiled-coil domain is required for assembly into the NuA4 complex.
Sequence:
MSNKRVRGLAIHRPILYGSTSTPLTPAEKLAAPPDHTHKWTVAVRSAASLPLPSLSAISGASDGSSFEPGSEVGAINAASGMATPSSSSAAGGSAATVSTRGRDQEHDYHKMVGNKDDISHFIKRVQFKLHETYSQPTRNVDKFPFHITETGWGEFEIQIKIFFVAEANEKPLTLFHHLKLHPWLQNVAAVETEPPAPPAPSLPAPLPPADMSATNSSVEQDGQASTSANGTKQEAGPDSMEVDPTASSTTEQQTSTDAKVESTPVAEPAVATTEPLKPALPPVVHSWQYDEIVFPEPMEAFYDILSTHPPTPLPVVSALAFADPAAYRSYLYAKADAAKGNSTGPPPIPPHPLHTPTGYLFDALSLEAQNAEGERLEMARIAAIKDLEKGREQLIKAEKALKDARNRIAALNNAALASCTAVSGTVPPAS
The following text describes a protein:
Function:
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein; This fragment is from the acyltransferase domain of the fatty acid synthetase.
Subcellular Localization:
Cytoplasm. Melanosome.
Sequence:
MGLRPDGIIGHSLGEVARAYYNGRISQEEAILSAY
The following text describes a protein:
Function:
Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation.
Subcellular Localization:
Cell projection, dendrite. Cytoplasm. Nucleus.
Sequence:
MSSEEGKLFVGGLNFNTDEQALEDHFSSFGPISEVVVVKDRETQRSRGFGFITFTNPEHASDAMRAMNGESLDGRQIRVDHAGKSARGTRGGAFGAHGRGRGYSRGKCSGKFDHGVWGEPPVSGLCLDNSHLNLSYLLQVVGTRAMGVAGMTVDLEDMDMDMEGPETMVAETRVVMTATQEEITETITTTEMRHAHLIVDTQGIKLLLIQDHPSKWLYL
The following text describes a protein:
Function:
Probable transcription factor, modulating expression of helix-loop-helix protein mbr-1, perhaps acting in concert with homeobox protein ceh-14. May play a minor role in axon guidance in the DVC interneuron.
Subcellular Localization:
Nucleus.
Sequence:
MTSKTNMTSNKFAYDFFPWSNDTNSSQQIKNIKPPPKRSNRPTKRTTFTSEQVTLLELEFAKNEYICKDRRGELAQTIELTECQVKTWFQNRRTKKRRCTSPLRKSMMKKSDERSPSPQNPSSQHVQNLQTFFHSWPSHFAYSLPSDQQNNV
The following text describes a protein:
Function:
Involved in the synthesis of phytochelatins, which are heavy metal binding proteins required for the detoxification of heavy metals such as cadmium, arsenic and copper.
Sequence:
MSQRRHFKMSVTAKNFYRRPLPETCIEFSSELGKKLFTEALVRGSANIYFKLASQFRTQDEPAYCGLSTLVMVLNALEVDPEKVWKAPWRFYHESMLDCCVPLENIRKSGINLQQFSCLAKCNRLKSTVSYGDNSPDFLKKFRTSLVNSVRSDDQVLVASYDRSVLGQTGSGHFSPLAAYHEDSDQVLIMDVARFKYPPHWVKLETLQKALCSVDVTTKLPRGLVELELKKGTRPLIMYGLKAYVNINDSDFATSVISWNQFLLCDPLEDDEEEFQLCCRKFGQCFAPHAMCCTQKTFDADQKNSCTECSTDQNEACKMICSEIRRTRFAEVFSSSAVAALLIAWPFEKGYSERSDRIGNLAEKYKNEFSAETMNEMNQLTTQIRTLISCSKPPVVININKPDATSNKCCKNKIGQSCACANDVNL
The following text describes a protein:
Function:
Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity.
Subcellular Localization:
Nucleus.
Sequence:
MAGRARSEDEEEDGQFTEHDYDVSLQKGPKKPWSKLRWTKDEDDKVKKLVEKHGEDWGVVARHFINRSEVQCQHRWHKVLSPELVKGPWTKEEDQRVIELVHKYGPKKWSIIAKHLKGRIGKQCRERWHNHLNPDVKKSSWTEEEDRIIYSAHKRMGNRWAEIAKLLPGRTDNSIKNHWNSTMKRKVEQEGYLQDLMNCDRPSKLQAKSCAAPNHLQAQNQFYIPVQTQIPRYSSLSHDDNCIEIQNSFSFIQQPFVDADDPEKEKRIKELELLLMSAENEVRRKRVPSGSSLTWSESYHMGESMSNTMSHLEEQTHDFYSLDEIPNTSGQQSVEDKILAPEANIVLQPLETIPEFSETLELIDVDTVDWNNIESFELPFTASPAKHTPMKWIHEISPECALNSCLVQADGRGSASRVLSSSPAMPKFYSPPTILRKKKIHPDLSLTPEVRDASNVVLKGTPVKTRQYSPLQLFRSGNVQNHLNLDNLPLTSTPVCGQKISATPLQRQITPKKDKENAGFRTPTIRRSLMAVTPRTPTPFKNALAAQEKKYGPLRTVMQPLIFVEEDIMEVLKKETEKDVFIKEEKESDCKPMKQEHVSTVRKVRKSLILDSCDKEELGADFLAPDEVSQSQNGNTLPTSFLMIPLGERQDQKCDENTDTRKGSVMQRKNYIPATRNVKLQSSVQPLCEWEAVVYGKTEDQLIMTEQARRYLDTYKPTSSSGLRHLIL