lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Subcellular Localization:
Cytoplasm.
Sequence:
MNKQIGFIGCGNMGIAMIGGMIKKNIVSPDQIICSDLNVINLKNASNEYGITITTNNNEVANSADILILSIKPDLYSSVINQIKDQIKNDVIVVTIAAGKSIKSTENEFGRKLKVVRVMPNTPALVGEGMSALCFNEMVTEKDIKEVLNIFNIFGQTEVINEKLMDVVTSISGSSPAYVYMFIEAMADAAVLGGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPSGTTIEAVVTLEEKGLRTAIISAMKRCTQKSMEMSSLTSK
The following text describes a protein:
Function:
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MPFFDKPEWIQHAGGVSIMGVDLDPSGVRMATCGSDNRIRIWAMRPVLSEVAEQDPAVPKQLAVLCDALTPINAIRFAPSSQLLAAGTDDSEGLVYELREGRGSAVFGSGESANIENWRLRIKLRGHASNVLDVAWAPDSRRLATCSVDNKVKVWDTTNGHCLRTLEGHVGHVKGVAWDPFDFFLASQGDREAIVWRLEDGSQVAIIREPFEKAPIVSFGLRPGWSPDGQTLALPNGYDKGMHTVPLIKRNSWVPGEFCLVGHKGPVTAIRYNPHLYTPAHKPGAAPTSPDDEAAGSIITAGSTDKTFSIWAPCAGDEPLAVARGFFGGMVNDVAWSADGRVMVVAAYDGSVATALFADGELGKRVPQAEVEALLAQLYGDPALRAGAAGREGGGGMGLGGRGGHSGLAAAPELMALEARARAEVEREERLNSRLRADGAAAAAAGAGAVVGAGTSGAAGPAAAGAAGLRPPLGAATGLARAAMPPTAPAAARVPLAVTQNGVGSAGRGAGVGSNSPAKAGAGGARGGPAGTSGRDADQPPAKRIAVQPVGSAATAMGARAGAATAATTATAPPGVAAGAGAGAGGHGAGGGSAAASPVLVPVEALHAHFSFLIHAQPGSTGEGQVELQALNTGRDARGRPAGELLCLVGGQRCWGDSVQGAVVALAGSSRLAAAATSNGDLMIYSSAGRRLFPPIRLGWPAAFLTVAPGSSLLLALLTDGSLKLWDFGAGECLLESSVAPLLLPPGAGVPGLAAAVAAAQPPVLKVTAVRITASGAPLVVLSNAHAYVHHGGLRTWVRVADDAFPASAFTTNLTSAATGELSKLQAAVAQRRHPADVMTTSALHAARPAAAARSEQAVLEHNLASAAALQSPAEWRLWLITYVRRLAADEDESRLRDLISELLGPLRWTPATHAAAAAGSSRAGGANAPAAAAAAAATSSSWEPALGSSVSGGRWAPVFLGFDKRRLLREVVLKEVARNRSYQQLVAEVLEQLKQVDAAAAAAAAVQQPHARGQADGVNAPAGDGAAAPAGAASSQPMVMG
The following text describes a protein:
Function:
Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors.
Subcellular Localization:
Cytoplasm.
Sequence:
MTGMSNVSKLAGEPSGQEFLVFTLGNEEYGIDILKVQEIRGYDQVTRIANTPAFIKGVTNLRGVIVPIVDLRVKFCEGDVEYDDNTVVIVLNLGQRVVGIVVDGVSDVLSLTAEQIRPAPEFAVTLSTEYLTGLGALGERMLILVNIEKLLNSEEMALLDIAASHVA
The following text describes a protein:
Function:
Fatty acid conjugase converting 18:2(9Z, 12Z) to calendic acid 18:3(8E, 10E, 12Z). Converts alpha-linolenic acid (18:3(9Z, 12Z, 15Z)) into 18:4(8E, 10E, 12Z, 15Z). Also has weak activity on the mono-unsaturates 16:1(9Z) and 18:1(9Z) producing two conjugated double bonds at delta(8) and delta(10) position.
Subcellular Localization:
Microsome membrane; Multi-pass membrane protein.
Domain:
The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence:
MGKGASNKKVLERVPITKPPFEYNDLKKAVPPHCFSRPLFRSFYFLLHDIIVTCILFYVASNYIPMLPGFLSYIVWPVYWISQGVFLGRLWMIGHECGHHSFSNYRWVDDSVGFLIHTATLTPYFSFKYSHRNHHAHTNSMEYDEVHIPKRKSEALDLYFEFLGNNPMGLMITMLCKLTFGYAAYIMFNYTGKKHKSGGLASHFYPQSPLFNDSERNHVLFSDVGICIVLYACYRIVMVTGAMSAFYVYGIPWVIMSAILFAATYLQHTHPSIPHYDTTEWNWLRGALSTIDRDLGFFNMNKTHYHVIHHLFPVIPEYHAQEATEAIKPILGQYYKYDGTPFLKALWREMKDCIYVESDQGQKKQGIYWFKNKI
The following text describes a protein:
Function:
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons.
Subcellular Localization:
Nucleus.
Sequence:
MLCSMANSGCLLLSSTAMIPHSISGPPAFLYLQQGNQDTSAPPEAMAQPYSTTQYPQPPQNGLPAEYATQHPLPTPDYSGQTTVSEHALTLYTAGHSHGDKPQGMEWSAHSLCRDHKHSQTDEVSQTDSSQQLQCPESTDKQQPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFETSMDADRAREKLNGTIVEGRKIEVNNATARVMTNKKPVNPYTNGWKLNPVVGAVYGPEFYAVTGFPYPPAGATIAYRGAQLRGRGRAVYNTFRAAPPPPPIPTYGAVVYQDGFYGAEIYGGYAAYRYAQPAAAAAAAYSDSYGRVYAAADPYHHTIGPAATYSIGTMASLYRGTYSRFTPY
The following text describes a protein:
Function:
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18. May play an important physiological function in brain.
Subcellular Localization:
Cytoplasm, cytosol.
Domain:
Both HotDog ACOT-type hydrolase domains are required for efficient activity.
Sequence:
MKLLARTLYLWEVGRQVASWSLTSGQECLVLRETWWASMRAVRTRAVHHKPGHCIAMGRIMRPDDANVAGNVHGGTILKMIEEAGVIISTRHCNSQNGERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVHVLSENILTGTKKLTNKATLWYVPLSLKNVDKVLEVPPIVYLRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPILNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDNSQKRYRAASAFFTYVSLNQEGKPLPVPQLVPETEDEKKRFEEGKGRYLQMKAKRQGHTEPQP
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MSGIELNHSRPTKKIFHRPQSFRDIQGWISKMNPELVKTVIESGKKPLHSAHYPPTLSLSMPETTPLTIFYNGIVNVFQVSPLQAEAVMKFAYGKETPASPSHNKLQTLNQGKLDVDESCSDLPIARKRSLQRFLKKRKGRVNMGAPY
The following text describes a protein:
Function:
Has a role in cell elongation and separation.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated at the cell tips during interphase.
Sequence:
MASQRFVIALHSFPGKSSDELPLVEGRKYLLIKMDEEFGDGWWEGEDEQGNRGIFPASHVELISDERSDSSDSRRGKEDFSISTAEVTRSSLSSSRSTSSRSDKDSEKLYSNNSLSSSHSSILNGPLDSLSKPSVPSNFNSMFPSSKQEGPSPLLDNQPSSDLSNFNTIDADYNNASASTSAPATSASLKKVLSAEDSVRETITDIETALQNMSTSASRTPNDSSPLPYIENRPASSLAVSEKIQNVPNWSTEEVVEWLMNAGLGSVAPNFAENEITGEILLGLDSNVLKELNITSFGKRFEVLRKIQQLKDSYEQSLYEEYPQFAEPISVSQSSDSSSSIPKKSNDEAGGSPSKSSPTRPGFNDYVNRPTSVMPSLSNMIVSPDLDSSPSTDWNQYVIPPLATPSSRNSKSTQSAVPENVSRFDSNEPSATSPILKRSSPTDSISQNSGLPSRLTEPISSPSTSSIDVDKEGTSFPGLPYHSSKGNLYAPQPSSNVPTKFTGGASESSSVPPRPIPSAMKGKAPASAISIEALEELDPPKITTIDGESPSSISSRLPSSNLEQGSSSSVTKSPESMPDPSAKASSPVTSKGVSINEKSAVNNYATPLSKPQPKDTKGSKLGNTFVAPSPAASLPASPPVGTELKTRPTLRSVASSPLNKEPIGKRKSKRDIFGRQKVLPTGISEGLSNIPAKEAIKTADCHGWMRKRSDRYGVWKSRYFVLKGTRLSYYHSLNDASEKGLIDMTSHRVTKTDDIVLSGGKTAIKLIPPAPGAAKAAVMFTPPKVHYFTCENNEELHRWSSAFLKATVERDMSVPVLTTSRMPTISLSKAKELRTRPPSLLIDDENEANLTSSIGLKKNAKQKNKKSSKQK
The following text describes a protein:
Function:
Part of an ATP-driven transport system CT_415/CT_416/CT_417 for a metal.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPMISILCSLFPPLLFPSLLAAFGASIAAGIIGSYIVVKRIVSISGSIAHSILGGVGIALWLQYQFNLPISPLHGAIASAIFVAICIGNVHLKYHEREDSIISMIWSIGMAIGIICISKLPSFNSELSDFLFGNILWVTPQDLYFLGILDLFIVATVSICHTRFLALCFDEKYMALNHYSIKTWYLLLLILTAITTVVLMYVMGVILMLSMLVLPVSIACRFSYKMSHIIYIASILNIVCSFLGIMLAYLLDLPVGPVIAILMGGAYSLSLLLKRSYNASTPSPVSPESKINS
The following text describes a protein:
Function:
Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me), with highest preference for trimethylated 'Lys-9' (H3K9me3) followed by dimethylated 'Lys-9' (H3K9me2) followed by monomethylated 'Lys-9' (H3K9me1). Plays a role in maintaining correct unc-4 expression in the VC motor neurons where unc-4 is expressed in the vulval but not in the non-vulval VC neurons.
Subcellular Localization:
Chromosome. Nucleus. Note=Colocalizes with H3K9me2/H3K9me3 in germline nuclei.
Sequence:
MSNEGSREESREPEAREGKSDEIFEVEKILAHKVTDNLLVLQVRWLGYGADEDTWEPEEDLQECASEVVAEYYKKLKVTDKTELIELLQKQIKKNKSQKSKKRSKTVSDHESNHDSDGSYGTPKTSKKSKKSAKNETPVSSKVPKVPTKAALKSYEATVSGPVAPNNAKKAAMEVRDTRRNWLDEESSDDEAETTAPLSDVEKIASKVKVVKAVEEKAEEPVKRPSTPPKPREVVIKKDPSESPVASASSVIPTSKRKSINAETSNGRQRTLAPPVIVKDETTWTVDGIARHTDVDNTKTKLILMTNSATGERKVVEGREAFELDGWALAKYLLDRCEF
The following text describes a protein:
Function:
Serine protease inhibitor. Inhibits trypsin (Ki = 65 nM) and weakly inhibits chymotrypsin (Ki = 295 nM). Does not inhibit bacterial subtilisin.
Sequence:
GEGACCNNCDFICGRAGFSRCRCLDLVTKCHPSCSNCEMTETPYWPCRYQCLDMDPDDCATP
The following text describes a protein:
Function:
With imt1 and imt2, is required for the synthesis of mannosylinositol phosphoceramide (MIPC). Catalyzes the addition of mannosyl to inositol phosphoceramide (IPC). MIPC is essential for cell morphology, cell-surface distribution of ergosterol, localization for plasma-membrane transporters, and lipid-raft-mediated endocytosis of plasma membrane proteins to the vacuole.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Sequence:
MNKILFYFFFFLTLILSATVYLFGGPMMLFFINYKTDLLKVDDVYNHEIYSNQSAAIPKIIHQTWKTNEIPEKWVGAQKSCIDLHPDYEYVLWTDESMREFIATDYPWFLTQYDSYPYNIERADVVRYFILYKYGGIYLDLDVGCNRTLDPLLHYPAWVRRTSPSGISNNVMGFAKGHPFLLQVVRNLPRFAFNYHFPYLTVMYSTGPLFLSIIWSAWRKLPDAEAWHHIWVMVPELYEKSHHAFFEIYEGSSWHDSDAGFVFYMLHHWAIFTFLGFLTFFIVVYFIFGYALKPAARVSRTGRRVFSSPFSKTSPSRWKIFHRFTSSNEKYDQTRSDSLPFMSDYDLESQTQSHSP
The following text describes a protein:
Function:
Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MPFPLLHPWPQRLALASAILLAAGCVTSEGLEPNARLQPAGALQAGRSLDGVALSPAAWPRQDWWTGLGDRQLDQLIGEALQGTPDLQIAEARARQAAATAQAQDAARQPTLDAKASYSGIRAPTSVAPAPLGGRYSAIKYLSLGFNYDFDLWGGERAAWEAALGQANAARIDSQAARIGLSASIARAYSDLAHAFTVRDLAEEELKRSQRMTELSQKRMSAGLDSKVQLQQTQTQLATARQQLSAAEQDIASARIALAVLLGKGPDRGLELQRPQPLNPASLSLPSVLPAELLGRRADIVAARWRVEAARRNIDSAKTEFYPNLNLGAMAGLAALHTSDVLQAPSRFFQVAPAISLPIFDGGRRRANLAERDADYDLAVGQYNKTLVQALGEVSDDLGKLRSLEQQVIDQRQARDIARSNFDLAMRRYGEGVGSYLDALSVQQQLLVAERQLASLESQQIDLSVQLVQALGGGFQPDSRSAALATAKAPAE
The following text describes a protein:
Function:
Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform TAA binds only to the receptor EDAR, while isoform TA-A2 binds exclusively to the receptor EDA2R (By similarity). May also play a role in cell adhesion; Isoform TAA binds only to the receptor EDAR, while isoform TA-A2 binds exclusively to the receptor EDA2R; Isoform TA-A2 binds exclusively to the receptor EDA2R.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein; [Ectodysplasin-A, secreted form]: Secreted.
Sequence:
MGYPEVERREPLPAAAPRERGSQGCGCRGAPARAGEGNSCRLFLGFFGLSLALHLLTLCCYLELRSELRRERGTESRLGGPGAPGTSGTLSSPGSLDPVGPITRHLGQPSFQQQPLEPGEDPLPPDSQDRHQMALLNFFFPDEKAYSEEESRRVRRNKRSKSGEGADGPVKNKKKGKKAGPPGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKTGTRENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFIYSQVEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKMVHADISINMSKHTTFFGAIRLGEAPAS
The following text describes a protein:
Function:
Transcription repressor.
Subcellular Localization:
Nucleus.
Sequence:
MDEDVLKEAIEQYKQQIIQIQTVLESGQIEGRAELAKLKDDLTELIQVTEESLLSLKKSQLLQLLEQQESSHHDSGTPETDTKTSVDYRNSYVNDHTIDDNDDEDNDENIIGTKCRVAFTQEWGVKEHHNAMVFKLESIPLDEETVDQAKVRVLFLNPTHRSMVPCPYFLEGKCKFAGAECRFSHGYLVDVEHLKPFKEPDFSSVKAGQRCLARYSDGVWYNSTIKSIKHESHEFLIHYETYNTDATLPLDDIYPLGPEEVESDSESDSQSDTGDSSSSKAAIEQDDDVIRYAWKPTGALSSLGDWEQHTKGIGSKLMAKMGYIFGKGLGKDGEGRVEPIEVVVLPQGKSLDKCAELREKNKLKEPFKRKKKKLVVASTTSASQGKASDVFDFINHKLGHSKGSLHDLRVSHPGAKPDIRKTRKSADENTNWNIQLFKIHEEISSVKKQLNKQEEALQRHTTRDSRNKTIFTEKRDSVHNRLQELLKKEKKIQEKIHQKDQHRKLTVF
The following text describes a protein:
Function:
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
Sequence:
MPLGKLDLVEEEYIAESGDHTPEASRLMGNGDSVVENLNGHTNGAVAKKKNEPRVPDMQLGKCRYVRLHDNVNYVAAAIILRNQGDDTEVLLIQEAKKSCRGKWYMPAGRVEAGETIEEAVVREVKEETGYSCDVVELLSLQVQGSGWYRYAFYCNITGGDLKTEPDQESLAAEWYNIKDLKANKVQLRGRDFIRLVDEAVTYRTHGPVDSIPRVMPLNQNVAGLFLEFMIVKHSRDGLRTEVLVHKSIKDETYLLEEEQPFPTVEFGFEYFFAMVVSKCYRHLLEEGANVVFTPSHVTRIKCHPKPMESLAHGVSIRVYCEHKQSASKAIIRSPRYHWISVESPETRQRFHMAQKQFRPSLHML
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of conidiogenone, a diterpene known to induce the conidiation. The bifunctional terpene synthase PrDS converts isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) into deoxyconidiogenol. The C-terminal prenyltransferase (PT) domain of PrDS catalyzes formation of GGPP, whereas the N-terminal terpene cyclase (TC) domain catalyzes the cyclization of GGPP into deoxyconidiogenol. The cytochrome P450 monooxygenase PrP450 then catalyzes two rounds of oxidation to furnish conidiogenone.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MLLLWFGFFSFIFGVVIYRLYFHPLSKFPGPKLAALTSLYEFYYNVVLGGRYLWEIERMHEKYGPIVRITPHELHVADPNFYTEIYAGPTRRRDKDPRLVRLAGQPTSMFATVDHGLHSSRRAILNSYFSKKSIAGLEDMIQGKVQKLVKRLSMACDQGTVVKLDAASSALTADIISEYAHGFFPFLLDLSKFIPDKVLEKLWFHAANILRLQKLVRAQADVALQNGGKVDGQATMFGALCDPSLPVQERTLDRLQDEGFSLIGGGTETTTGTLKIVMFHLLNEKALLLKLREELEQYPSSTWADLEKLPYMRGTINEGLRLSGVITRLPRRAPDEALVYKQWTIPPNSLMSTSSHFVHTNSDLFPNPLAFDPERWIRAEAAGQRLEHMIVTFSKGSRQCMGNHLALAELYLVISTLVRRFDMDLYGVTADNIVTHREYGFGVPKERGEGLRVSITRVRDP
The following text describes a protein:
Function:
Microtubule-dependent motor protein required for mitochondrion morphology and transport of mitochondria in neuronal cells.
Subcellular Localization:
Mitochondrion membrane; Peripheral membrane protein.
Sequence:
MSVKVAVRVRPYNARELELNCQLCVAMNGPTTILLDIEDPKKNRDFAFDYSFWSHDSFENDENGYSRAIPGTKYADQQMVFDTVGQEILNNAWQGYHCCLFAYGQTGAGKSYSMVGYGANKGIVPISCEEIFKRIKKNPDSQLTYEVQVSMLEIYNEKVQDLLVPVPKRPTGGLKVREHKVYGVYVEGLTKYPVDSYEAIEAKMDEGSKHRTVAATQMNASSSRAHTIIQIEFKEIKNVDGRKSEKLSVINLVDLAGSEKVGKTGAQGDRLKEAGNINKSLSVLGQVIAALADKAMGKGKNAVVPYRDSQLTRILQNALGGNSKTLMICAVSPATDNYEETLSTLRYADQAKKIKNCAVVNESDVDKKLREQQEEIHSLKQQLMMLQTQLKGGVINPEMLKQLSQIQDDIETNETIMQENQESFESKLQKQKQKDEEEDDEDIQNEGIKEHPHLLNLNEDPLLNRKILKSLNQEETHVGRPNGNPTPQIVVNAMCVQPNHAIITNKEGVIEISPFTKECGDFIFVNGSPITGPTLLNHNDRLIFGTTTTFLVQIPGSEQVEQGPEIDWELAQQEMQKKEEVKRQEQQKLAEKQVHEEMQRKKQELEEQRKEEQRLYEEQMKKQQEDFDIKMKALEEQNKDMLNRALMAEEERKLIEERKKLEEETLQKQLQREKARKQYEDEETMKKYRIKEKNFIENKLQKYLPKVLEVNLIAKELKRNVTLEARLKYVYADDQEYSQFTEENAQKGQIQIQVNNKEEGQIYYWDLHKFSNRYYIIKDLLERYFESNQLLQLPKDQDPFWDPPEARVIGSGFLKLQALAYLMDNPCDLTLVGEHFQCGTLKVNLIPTDETGQRNLSEDIEDGIEPPVEDPSELVGRRFDFRVSIESARLPENLCKDTYVEYSIQVEEKKKESFKTKTLAGAHPNPIYNYDQQHTFDQLSETQLNYLINGTICFKVYGYDENKNKDAKKREIPVENLIPQQQTTQQQQQIQQQSPQPTQQIDQAKKQEEHIDILTKTINQTKNIQQQQVSQQQPIKQPTQTTQVKPPIEKFAQNQPVTQPISRQSIKEFEDHTSEQQQMKAKLQQQQMNAQKPRSSSQDRTPAMMSKGKPDPKKGTKKDDGCNIF
The following text describes a protein:
Function:
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments (By similarity). Required for nucleus structure organization (e.g. size and shape).
Subcellular Localization:
Nucleus membrane; Peripheral membrane protein. Nucleus, nucleoplasm. Cytoplasm. Nucleus lamina. Note=Recruited to the nucleus envelope (NE) by SUN proteins and is immobilised therein (By similarity). Punctate or bundle-like structures are detected, especially in trichomes where bundle-shape localization pattern along the long axis of the nucleus is observed. During prometaphase to anaphase, localized diffusely in the cytoplasm. Later transferred from the cytoplasm to the chromatin surface, preferentially assembling to the distal surface of the chromatin. Relocalized to the nuclear periphery during late telophase.
Sequence:
MFTPQRNRWPETDRKGKAIAFSDEIITPPPQRVLLREDDDWQKFKEVGLLDEASLERKDRDALIEKILKLEKELFDYQHNMGLLLIEKKQWTSTNNELQQAYDEAMEMLKREKTSNAITLNEADKREENLRKALIDEKQFVAELENDLKYWQREHSVVKSTSEAKLEEANALVIGMKEKALEVDRERAIAEEKFSVMNRKSSELERKLKEVETREKVHQREHLSLVTEREAHEAVFYKQREDLQEWEKKLTLEEDRLSEVKRSINHREERVMENERTIEKKEKILENLQQKISVAKSELTEKEESIKIKLNDISLKEKDFEAMKAKVDIKEKELHEFEENLIEREQMEIGKLLDDQKAVLDSRRREFEMELEQMRRSLDEELEGKKAEIEQLQVEISHKEEKLAKREAALEKKEEGVKKKEKDLDARLKTVKEKEKALKAEEKKLHMENERLLEDKECLRKLKDEIEEIGTETTKQESRIREEHESLRITKEERVEFLRLQSELKQQIDKVKQEEELLLKEREELKQDKERFEKEWEALDKKRANITREQNEVAEENEKLRNLQISEKHRLKREEMTSRDNLKRELDGVKMQKESFEADMEDLEMQKRNLDMEFQRQEEAGERDFNERARTYEKRSQEELDNINYTKKLAQREMEEMQYEKLALEREREQISVRKKLLKEQEAEMHKDITELDVLRSSLKEKRKEFICERERFLVFLEKLKSCSSCGEITENFVLSDLRLPDVEDGDKRFGKQKLKAEEALNISPSAENSKRTSLLGKIASKLLSISPIGKTDKVTDLGITVKLPESSQPDDSLDRVSGEDHEPSATEQSFTDSRIQEGPEGSLQSEMKSDKPRRGRGRGRGRGKSVRGRSQATKAVSRDSKPSDGETPRKRQREQTSRITESEQAAGDSDEGVDSITTGGRRKKRQIAVPVSQTPGQTRYQLRRHRNVGTEEDKAQASKGATEKQERVNDDIRKVPSPKETRTPPEGENRENGKAEVLVETVTHEEIVTVETETVFKVNNTGKNPVEDPQLEVGGSGEIREHGEEDDENISMIEEENEGEEEEETERQGNDASIGKKIWVFFTT
The following text describes a protein:
Function:
Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape fen1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit dna2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for fen1. Is a target of the intra-S phase checkpoint, associating with stalled replication forks when phosphorylated at Ser-219 and preventing the stalled replication forks from reversing. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA. Also required for the production of G-rich single-strand overhangs at telomere ends and thus in telomere length maintenance. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is atypical: it cannot load onto its tracking strand internally and has an absolute free 5'-end requirement. Helicase activity may promote the motion of dna2 on the flap, helping the nuclease function.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome, telomere. Note=Recruited to double-strand. break (DSB) sites.
Sequence:
MFNDQSKTTSSVKGICATTDNNHGNLKKTNSTPFRKNYLLNGRTKLKLENFAYNASTEISSPKISEKKHSSLPIKRKNTFNESSTSFSPFTKAHKEITDDLKPDKSFTRKSDLNSQDMPVCFQETSKDLCRSSSTQHLLDHQTTDSTIIDMKPVSTNSKSDVFTLYTDETVLLRRCASDNKPLINNNLSSSNVSENQSRSFGSYDEVKNQGNNLHKVPSLVSIIRNARSSEQSRIAANSSCLLKGSDTEIDEDDFALEAEDLAALDSLERQYSQLPNSTVTASAKDIEKTAKVNHVGGDLQSYCSATKASDATINEEPVNLALDKACNSLPDINSDFIDDWDDSCDGCTPGELCEFSSEYTVLEVHEDFIFHEGNHFRQLKLILEANDILHQLFLRGDWTETSIFVGDSIRVEATFDKDNTAIVDNDKGLIIIHPKILMSATAVASSFPCLRKAVISDRVGIYGPPTKAMVTGNILHDFFQHALYRGIDALENVDINLETSIKTYISDIYFADLSLDEIREELDARLPLLKSIVERYLISKKNDNNNESIHISRLLDIEESIWSPRFGLKGNIDATVEVVLTEKPESSSTLTLPLELKTGRYVDNISHFAQSLLYTLLISDRYGINTNQALLCYLENSTIKNLVASNSQLRGLIMTRNSLAQHNFRRSLPEMISNRKICDHCSLVSECLFFQKMSDKGVANSNGLTESWNEWMREVKDEDLEFYKKWEKLLNQEERLLLLKRGDVLTFDTEELEAYGKTLYPLYITKEDIVCLEIDDRVFHYKFAFLNDNGYPRNFLHSGFSVGERVFISDEHGHWSLAKGHIVHIQDSCIEVRTRHRLHIPWLKMPNFDFKKNQVFFGNYEDSKLSFIGSNHTRYRIDKDEFSSGIASIRGTLMSSVLPDAPLIIRDMIIRLKPPKFCNSALIDPEFLKCLNEDQITALKKCHAAEHYSLILGMPGTGKTTTISSLIRSLLAKKKKILLTSFTHLAVDNILIKLKGCDSTIVRLGSPHKIHPLVKEFCLTEGTTFDDLASLKHFYEDPQIVACSSLGVYHSIFNKRKFDYCIIDEASQIPLPICLGPLQLAEKFVLVGDHYQLPPLVKNSRTSKDGLSLSLFKLLSEKHPEAVTTLRLQYRMNEDINSLSSELIYGGNLVCGSKTISQKKLILPKAHLSDGLPDSSSSLHWVNKLINPSHSVIFFNTDDILGVESKTNNILENHTEAFLIEQAVSSFLERGVKQSSIGIISIYKSQVELLSKNLKSFTEIEINTVDRYQGRDKDIILISFVRSNSKNLVGELLRDWHRLNVALSRAKVKCIMFGSLSTLSSSNIVSHLLKLLEKNKWIFTLNENDIATKFDENSSPIKDCSQVATTNNAKVIIRKNQRFFNSDNLCEKAILPQLEF
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MKGERRVLLEAESCCLSLVKPSCCWGSPRPCLILPHAACSEELSAFLSMECLAVPLWSKARTEKCFSAAADFTLSQWRSGGAIKPRARSIAGSLKMSGKTASTTNNIAQARRTVQQLRIEASIERIKVSKASADLMLYCEEHAKKDPLLMGIPASENPFKDKKTCVLL
The following text describes a protein:
Function:
Component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Has a role in regulating heterochromatin propagation and euchromatic transcription.
Subcellular Localization:
Nucleus.
Sequence:
MPNSSYYDDDGGSFEAASYPFQFDGSRRFPNDLHPTMFEGEESNQNGGSVLIDQAFQDIQNPNVNSNMHLENQFQHFHEPNKESGAFGSYKNDDVAKEIESSKNQETDAKSEQAPFTEDASSSNYAHHRSADSQTKSALPPNVPASSSPLPPMSIAMNIARKRSWPASLAIERDNTADALFSTEDGREEQFNLEGVKTKSGRKVHRPNHFDPLVKLPTRRRGPGRRPVVALAMKCSVCQRLQSPPKNRIVFCDGCNTPFHQLCHEPYISDELLDSPNGEWFCDDCIRRKKQAPLVTGTTARELNLSSEEKKSYLLSLPISQLVDILLFCEQLHPDIPFYSPKTSTIVQELQSKRSAFTATMNEPVTGDQYLSLNNGTESQSKTTKHSTSLPSTEPVEVDKQYMESEKIPTIDEYLQEYSNEDEIVLQVLESFPAAVSFSTITNTIQAKYSNRKIKNSNITRSLNRLVRKNRVLRDARGSSYELNRTFDADRPSVRPDISITGPIPIDWMLYTPHTEDLTENFCTYYMFDETPIVLSSI
The following text describes a protein:
Function:
Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.
Subcellular Localization:
Nucleus.
Sequence:
MAYMKSPYGMNGLSLSNPSIDLMTHHHHPGVGVSQYYNPTSAYTVAGQCPPPPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQAGQAKPRPKKKSASPPPASTEEQAPTSESPSCSDSSVSSTPVPVAVTIGNTNASPTAAVSTSSIWSPASAPSVTSDLGSCTSTVTSAPSCMQRSSYNHAYNHGGYTAHAQTYSPAPYPPTTYSTSYFGGMADCSSYLSPMAPTHQLPPVTTLNQMSSANMSAHSMSHTPQLSPSSMGHGSPLNMSTQPDCVDYTKHDQTSAWHKFQVL
The following text describes a protein:
Function:
Plays a central role in autophagy. Acts as a core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (By similarity). Involved in endocytosis including endosome formation in neuronal cells (By similarity).
Miscellaneous:
MISCELLANEOUS: Expanded poly-Gln tracts inhibit ATXN3-BECN1 interaction, decrease BECN1 levels and impair starvation-induced autophagy.
Subcellular Localization:
Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Endosome. Cytoplasmic vesicle, autophagosome.
Domain:
The coiled coil domain can form antiparallel homodimers and mediates dimerization with the coiled coil domains of ATG14 or UVRAG involved in the formation of PI3K complexes; The C-terminal evolutionary conserved domain (ECD) contains poly-Gln-binding domains such as the ATXN3 poly-Gln motif, consistent with structural docking models revealing two highly scored poly-Gln-binding pockets in the ECD. As some binding is observed with BECN1 lacking the ECD, other domains of BECN1 may also interact with ATXN3.
Sequence:
METLRFSSNTMQVSFVCQRCNQPLKLDTSFNVLDRMTIHELTAPLVMVTANKQQDSGESSSFPEETFLENKQDGVARKFIPPARMMSAESTNSFTLIGEASDGGTMENLSRRLKVTSNLFDIMSGQTDIDHPLCEECTDTLLDHLDTQLNITENECQNYKSCLELLSQLPEEEEASLLNALQQLKQEEESLIQELESIETKREAVAKELDEGRNHSQLMDTEELRYQKEYCEFKRQQLELDDDLKSVDNQMRYCQIQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALASKMGLCFQRYQLVPYGNHSYLESLSDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKDDTGFCLPYRMDVDKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNR
The following text describes a protein:
Function:
Has a crucial role in plant growth and development, possibly by influencing mitochondrial division.
Sequence:
MRRIVRALRPLQKLTSHTTQFPLPVHRLLSTSSSSSSSAVAASSDSDSAAHDADFNSADFSLPPTDPSPASAAAVRNPLSALCKVRFDPSLRARADEALFGEKNAGMGVEDAVEEERSREVALALLEAALEPPDEDEEGGPEEVRKEDQMSLSVGIVGAPNAGKSSFTNTAVGSKVAAVSRKTNTTTHEILGVLTKGKTQICFFDTPGLMLGHHGFPHRDVTVRVESAWSSVNLYDLLIVMFDVNRHLKMPDSRVIKLIKRLGAEVAKEFEDLPGFERYFMVSGLKGKGVKDLVQYLMDQAVRRPWDEEPATMTEEAMKTISLEVVREKMLDHIHQEIPYVIEHRLMDWKELKDGSLRVEQHFIAPKQSQRQILVGKNGSKIGRIGIEANEELRSIFKRDVHLMLQVRVAKKRSS