lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Sequence:
MGKGNQQAASLAHFKASSSARAAERQGGQLRTFSAFSNTAGTPGATAGRGYLVPGEDDKLMPDLKQALSKLKKRDAVTRVKVDASHRLRPAFVHGAPAHAQRALTLLLAFTQTLEEVLAILNGTEDDQILATLEHWPRLYNRLSQDADRRARDFTARVWAVLATRAGKRIAPFLKAILPAWLLAQHDPSREVAKQTRDTFTTLFATSDKQHKTISFAQEEIVAAYRFNLLELSLEDLRNQNTGDDEQELRDKHSRILTNTLLALGDVLRLDHEALAVAYPALQELFADSRLWKLHKLDNPDILASLYALVGTAVRFHPDLLDHDLKRVASLLCKYVPSTLGSHGSRTPQDVWSVLSPQKTLLPRVWQLSAQLGGAIAETFFNGLVPLLACIPSDLVEGVQLFEACTEALLAGLVGKASRATCPGSIYLGAWQALLLHFGPTHQELAQNALVQLVQTLCFNPSADWVRAEQLIQFCSTIASTNELASLGLLRDALDALARRQVAWITEVAASPASAASTPHVDDDVADGNESPPLSPSTVTAPADAAPARVSFAPDATAMLPAGEVPSAEVQSKPEAPEVRLRAQRALAVLSALLEADPELRGHVSGNLVLPGLSVWSEAGDLPVSLAHFILKAAQGCTLTTEQAADVLARVDALTSVVAAASRADLFGLACRSLMAADAHAQEQWSARLVARAGELDQRSVLLEALVCVAPREGANWSTALIEQLAREVHALEDATTSPTAQVQDLATAAGHLWCLSVTATTSDALRPVLLDIRPTCHDLLAVEASENSAARTFALAVHDGLSPTSAFATEQLSEVSWLLTRCVEVLAHRSAQPLCVQADALPSDLPARLNAVLQRVLTVLYHDVGPSSAIVLELLESVLNGPVWQKGSALDHALGAAMTGLPLPVRTAVLGRLATQAELRMSTGGPPSLKDLATGLVTFGDVDLARIEEAVSQRMALAPARRLLDLLVTESGWDAFSADQSVSAEQLAGLTSLWALERSDATEVGARALDDDFISPVLSNSTAPLPAIELLQAALCLKEENGRVAYLQAILSRVEGLLGLDATVLAAQALAKWPATGAVWTAALDMKLTSARGAQAIQLLAAYLPGPTGSAQTAPLLASLTTRVEGVAHEGLSLLDDPSPLLSPILACSVVAANLARSRYQVDMAAAAALADEAQQALSEAARAALQRQQATRIQLPEGSTKVIQALRQCLEVIQSWQDAEEELLEFREDDEDELPRPQRLVKMAVASGMKAAPPALADAAREWQSFFLPNSSEICYAHLERSAAAALAGNTGTVASALHAVIGELGQLCLDDEDKASGWGVSDADDELEEELETTSEGVVVVRATQRERPADIMLKFLEPFILALGGDERRCEAEEHAVDLLWQRGHLLLWNLLTVVFERVSAELRPALANPLLYEGTFCPSLTYYFDHFLENQRALPTDIGEMLERPQAQRLGDLAPSPAGLVRLAALVYGHFFLRMPAMAVSSFTSTIVSPVVCRGELNAADARTVGSDDEDESRVTVQSRFAVREVSAVYRKDTLTLELVIKLPEDYPLSKAEVGRERATGWQMDNRLYPSNPGFWVVYVDLTGAACGHFWGQMAQVGSVTLPLHQQPERQHRGCGAIVEAKRGQDF
The following text describes a protein:
Function:
Structure-specific DNA endonuclease that specifically cleaves single-stranded DNA and 3' overhang DNA. Contributes to the control of DNA double-strand break repair choice by antagonizing BRCA1-dependent homologous recombination (HR) and promoting non-homologous end-joining (NHEJ). Recruited to the single-stranded DNA ends by SHLD2 and cleaves the 3' exposed DNA ends, therefore inhibiting DNA end resection (necessary for HR) and promoting DNA end protection (necessary for NHEJ).
Sequence:
MGIRGLMSFVEDHSNEFFTDLKLRDTKIVIDGYALFHRLCFSSNLDLRYGGDYDSFADVVQKFFESLFACNICPYVVLDGGCDISDKKLTTLKDRAREKIQMAHSLSVGGSGYVCPLLIREVFIQVLIKLRVCFVQCFSEADRDIMTLANHWNCPVLSSDSDFCIFDLKTGFCPLNSFQWRNMDTIKGTQNYIPAKCFSLDAFCHHFSNMNKALLPLFAVLCGNDHVNLPIMETFLSKARLPLGATSSKGRRHHRILGLLNWLSHFANPTEALDNVLKYLPKKDRENVKELLCCSMEEYQQSQVKLQDFFQCGTYVCPDALNLGLPEWVLVALAKGQLSPFISDALVLRRTILPTQVENMQQPNAHRISQPIRQIIYGLLLNASPHLDKTSWNALPPQPLAFSEVERINKNIRTSIIDAVELAKDHSDLSRLTELSLRRRQMLLLETLKVKQTILEPIPTSLKLPIAVSCYWLQHTETKAKLHHLQSLLLTMLVGPLIAIINSPGKEELQEDGAKMLYAEFQRVKAQTRLGTRLDLDTAHIFCQWQSCLQMGMYLNQLLPTPLPEPDLTRLYSGSLVHGLCQQLLASTSVESLLSICPEAKQLYEYLFNATRSYAPAEIFLPKGRSNSKKKRQKKQNTSCSKNRGRTTAHTKCWYEGNNRFGLLMVENLEEHSEASNIE
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.
Subcellular Localization:
Nucleus.
Sequence:
MSSSAHFPDRDNFQCRSDEFTTWLSSRPGVKVNSKIRIADLRANAAGRGVVAQADIDEDEELFAIPRDLVLSTHNSKLKDLLSQDLDQLGPWLSLMLVMIFEYLQGGKSTWAPYFKVLPQNFDTLMFWSPEELEELQGSAVVEKIGKQGAEESILKLIIPVVRANPALFPPINGLASYDGDVGAQALLGLAHTMGSLIMAYAFDIETPENEDEREGEDGYLTDEEEEQSSKGMVPLADMLNADAYRNNARLFQEEESLVMKAIKPIRAGEEIFNDYGEIPRSDLLRRYGYVTDNYASYDVIELSLDTLCSSAGLSDSSIENQPRLEFLESLELLDDGYAISRPSPNDTLTDIIPEELVVLLKTLTLSPEQFTHQQQKQKPPKAAFGQEEAKILFDSILMSEKRYSTTIEQDQELLAQINQVEAVSPLEGSDRRRKMAIQVRLGEKEIFEAVKAKINDHFTNSSTSKRIADSNGDDLRRTKVQRT
The following text describes a protein:
Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI
The following text describes a protein:
Function:
Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MGRARRFQWPLLLLWAAAAGPGTAQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAAVLRWYRDRKELKGVSSGQENGKVWSVASTVRFRVDRKDDGGIVICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEALGETLTLPGLVSADNGTYTCEAANKHGHARALYVLVVYDPGAVVEAQTSVPYAIVGGILALLVFLIICVLVGMVWCSVRQKGSYLTHEASGLDEQGEAREAFLNGSDGHKRKEEFFI
The following text describes a protein:
Function:
Part of the Notch signaling pathway.
Sequence:
MCQQVVVVANTNNKMKTSYSIKQVLKTLFKKQQKQQQKPQGSLESLESVDNLRNAQVEEAYYAEIDENAANEKLAQLAHSQEFEIVEEQEDEEDVYVPVRFARTTAGTFFWTTNLQPVASVEPAMCYSMQFQDRWAQA
The following text describes a protein:
Function:
Involved in lignin biosynthesis. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH-dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.
Sequence:
MAMSPENEHPVKAFGWAARDTTGHHLSPFKFSRRATGENDVTFKVLYCGICHSDLHSIKNEWGITSYPIVPGHEIVGVVTEIGTKVTKFKVGNKMILSYGAKYNDGTTTYGVYSDIMVSDEHFIIKIPDNLPLDGGIVGLGGLGHMVVKFAKAMGLKVTVISTSPNKKKEAMDHLGADAFLVSRNTEDMELAMGTMDGIIDTVSAVHALLPLFNLLKINGKLIMVGAPEKPLELLSFPLLMAKHNIVADIELIPMDYVNTAMERLSKANIKYRFVIDITNSLKPF
The following text describes a protein:
Function:
Serine/threonine kinase involved in the regulation of key cellular processes including the cell cycle, nuclear condensation, transcription regulation, and DNA damage response (By similarity). Controls chromatin organization and remodeling by mediating phosphorylation of histone H3 on 'Thr-4' and histone H2AX (H2aXT4ph) (By similarity). It also phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity (By similarity). Is involved in the regulation of cell cycle progression of neural progenitors, and is required for proper cortical neuronal migration (By similarity). Is involved in neurite elongation and branching in motor neurons, and has an essential role in Cajal bodies assembly, acting through COIL phosphorylation and the control of coilin degradation (By similarity). Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, it is required to induce Golgi fragmentation (By similarity). Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates TP53BP1 and p53/TP53 on 'Thr-18', preventing the interaction between p53/TP53 and MDM2. Phosphorylates ATF2 which activates its transcriptional activity. Phosphorylates JUN (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Nucleus, Cajal body. Note=Enriched on chromatin during mitotic chromatin condensation.
Sequence:
MPRVKAAQAGRQGPAKRRLAEHFAAGEIITDMNKKEWKLGSPIGQGGFGCIYLADMNSSKSVGNDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTHKLKYLGVPKYWGSGLHDKNGKSYRFMIIDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLSYKNPDQVYLVDYGLAYRYCPEGTHKEYKEDPKRCHDGTVEFTSIDAHNGVAPSRRGDLEILGYCMIQWLSGHLPWEDNLKDPNYVRDSKIRYRENIASLMDKCFPEKNKPDEIAKYMETVKLLDYVEKPLYQKLRDILLQGLKAIGSKDDGKLDLTVVENGSLKAKPVAKKRKKEAEESVESSVEDMECSDKQTEEATQTRSKTRKRVQK
The following text describes a protein:
Function:
Has growth inhibitory activity.
Subcellular Localization:
Secreted.
Sequence:
MACRDRVTMIAYVLLLVVAFSTVDAMDFFSNFDGMFDDPFMLMFQNRSTCGRRTVASTMTGPTTQAGDGTEHEVVAGEYPWQVALYNGEMKLCSAVLIHEQWLLTAASCIPYLKEPYTVIAGAISLLHSDDDTGNDDGSQHTQRRMTSEIYIHPGYDARRMESDIALVKVMIPFELNDNVNVICLPNPKMHRDFRPGSKTGIAGWGHLPPVTERPGMCPKPTGDILNECDVEMCETDAECSEGEKCCRNGCDVMTCMEASPPGPGPRPGALMGGVIPLINHTMCNQTMMGAIPKGVICAGPTPMKHEGGGKEMMEEGGIVALLKWKREMREMEQRNGDDTDDDDRNVLFRGVDLVQTMSLIVKRIEGSDGSADAYGRRQSGVWSIGMTGEVMRSRTVSDGDDDGDDGMEDGWMKEGMEGEVDDVEGAWMGDGMEGGMEDKMKEDVRATKEKMMMTMMKKNCRGDLGSPLVAELEGRSYLLGVTTLPRGCLFGASPGLFTHVFNLHEWIRPIFNRKEPKRKRTMCTAGEFSCGDGWCIPEEYRCDGKKDCKLGTDEGQFCKGAMKGFNIYLDQHLNRSTVARPFPVTSFSQCAQACLMEPYLCPGFDVILLPTEADSPPIVSKPSTDDGGDYDDDDGDDDVDDGTKDVPYDVEDERGDKMPMMMDGMTIMCLLANSTSSVVGNKGKDISISRLNKAMMGKMPLAKPVYLHFKLPRHAPLAALFSPIMNLYLPTGLIVSPSYILGHDLAALLEDKSMALRFIKKLLMEDLVQTSCIFCFMSHPRWGAVREMEERVKMMREEAKNVLGVMMDEEGAGGGDGGMEGYVMRVREMKMQMRQMARNFTRVMNGMQADCDVMDIKRGLMMRIRRMMGNASCDMMGEDGDMVDGELREMEGGEDKEKPDSVMAVVMEMMEELGEVMPDLLMENMYPERDGMMTMMEMGLGVKMMMGRGSMMGDSWGMLGNGDVMSSFLTEKVETMMGMDPEDLAQNVNTSKLVTMMTREVVMIGHALATERCNQGNMTSGDAQEGWTPAMDADMDADDMPEANTFDTMRMKELGMRAKVGHQKWSIALSPRQVNTVNFRVLDVRGPMRGGGNIGKGFGMVVARGLGGVPMATDMIVSHVIRKMAITDQKMMDRDWGSREDMDGMSDGMGSPMTEEERGAMDWDRSTEDADTAAMGGVLPGNIDEDIFWKVVESLTEMTITSEMDRGSDLTHLIEAIWNGDIGKEAFIHGVGPSVFHRLYARVMMQQKMLDAPGRAYRLGDLHRGKSFDVYGSLVDVEQYTTNESDHGILMEYKAGWSCNQKNNKNMRVLTSPNFPRAYPSNARCNSFISAPPGHVVVLFVMRFKLQWSPYCLQDSLTVYDETTPQNWVKLGQGPFCGTTVPHIFRSSGQNLLVKFVSDVYHVGSTDKGFKIIYAFQPVARAMADQEAGPSSSSSEPEMTRTDAQTNMKVMRDKLMCMQISLGVISGVLFLVVVVGLVWIHSHSKTRREKAKEVYDTKF
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MQIPFVTYFAEYLGFFIAFFANLTLIHLILTRTKNNFGSYKYLMLWFACFSLWYSIIDILTQPAMHSYLNSYIVFCASWFKYDPVLAPIIITSYCTSYGLTLVLLAIHFIYRYIAMIRPNQIHWFKYPHALIWPIIFSVVAVFWWCNVYFLLSSNPTFDAYLNETIYENYEERIERLSYIGPLYFIVGEQGDIQIQWKSCLGMINVYCIITTLVTIMCLGYSVYKKMQSVNDLVAEKTRALQKQLFHALVLQTIVPIIFMYSPTTVLFICPIIGVELGVIANMTSICLALYPALDPLVVMYFIRDYRTYLMKKLNLTRSVSTTTRNTSITKHDTGII
The following text describes a protein:
Function:
Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation (By similarity).
Sequence:
MYPYCLKYLTNGLRSKQMINFLCIQNILSARTLKICRFRFLPTPSHPTHKMAQETRAISSISEAANKRARKLSKRRAKKPVEEGSSGHVLLLEIENLIEKPVLANVPFERFQEIEVKISYLSSSGDGIGLVCNDQYAVVVPFTLPGDIVKAKLHFLADTYALADFLEVISPSEDRDDTLIKCPYFAKCGGCQYQMLSYDKQLLQKKRVVEKAFQYYSKLDSSLLPAIKDTVGSPLQYNYRTKITPHFDVPKGGTKGPLIIGFQEKGRRRVMDIEECPIATKTINEEYPKIIEDVQSRANTFKRGATILMRDSATEDGKHCVITDHKMIVREQFGDLSFTFPAGAFFQNNNSILEKFTSYVREQLLNPFGRKEHQRPKYFVDAYCGSGLFSVACSKGFLSVIGVEISADSVRYAEENAKRNNVSNATFIVGQAEKIFSSIETPPNETAMVIDPPRKGCDQSFLNQLLEYSPYRIVYISCNVHTQARDVGFLLSQEKGRSYKIDEIRGFDLFPQSHHVESILTLTKVVS
The following text describes a protein:
Function:
Functions in nuclear protein import.
Sequence:
MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVSLPINDDSMLESPIQDPDISSTVPVPEEEVITADMVQMIFSDDADQQLTATQKFRKLLSKEPNPPIDEVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCGILPPLLEKLCPLSDWPDSSTFGPPLTVPTGGYFEKGGGLRDLNSSLITSSQGRLLTNSNRLTTTRNAVWALSNLCRGKNPPPDFSKVSPCLNVLSRLLFSSDPDVLADACWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESRQNEMNINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDEDANIVPQVDENQQQFVFQQQEAPMEGFQL
The following text describes a protein:
Function:
[Capsid protein VP1]: Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulates the genomic RNA and is decorated with VP2 proteins. Attaches virion to target cells by binding histo-blood group antigens (HBGAs) present on gastroduodenal epithelial cells; [Soluble capsid protein]: The soluble capsid protein may play a role in viral immunoevasion.
Subcellular Localization:
[Capsid protein VP1]: Virion. Host cytoplasm.
Domain:
[Capsid protein VP1]: The shell domain (S domain) contains elements essential for the formation of the icosahedron. The Protruding domain (P domain) is divided into sub-domains P1 and P2. P domain interacts in dimeric contacts that increase the stability of the capsid and form the protrusions on the virion. A hypervariable region in P2 is thought to play an important role in receptor binding and immune reactivity.
Sequence:
MMMASKDATSSVDGASGAGQLVPEVNASDPLAMDPVAGSSTAVATAGQVNPIDPWIINNFVQAPQGEFTISPNNTPGDVLFDLSLGPHLNPFLLHLSQMYNGWVGNMRVRIMLAGNAFTAGKIIVSCIPPGFGSHNLTIAQATLFPHVIADVRTLDPIEVPLEDVRNVLFHNNDRNQQTMRLVCMLYTPLRTGGGTGDSFVVAGRVMTCPSPDFNFLFLVPPTVEQKTRPFTLPNLPLSSLSNSRAPLPISSMGISPDNVQSVQFQNGRCTLDGRLVGTTPVSLSHVAKIRGTSNGTVINLTELDGTPFHPFEGPAPIGFPDLGGCDWHINMTQFGHSSQTQYDVDTTPDTFVPHLGSIQANGIGSGNYVGVLSWISPPSHPSGSQVDLWKIPNYGSSITEATHLAPSVYPPGFGEVLVFFMSKMPGPGAYNLPCLLPQEYISHLASEQAPTVGEAALLHYVDPDTGRNLGEFKAYPDGFLTCVPNGASSGPQQLPINGVFVFVSWVSRFYQLKPVGTASSARGRLGLRR
The following text describes a protein:
Function:
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MINKKQSLTLLSAIALSVSLSACSVFDWLIYKPDIPQGNYMEPQQVEKLRIDMTKEQAEYILGRPVLRDSFADDTWYYVYHYKSGRDASITHKELILHFTGNKLSLVKGDYELSPEFNTPLEQSKLPMVNTTESAPQVPAQRPDEKPLVKENQTEAQVQKPIK
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MEQQQPNHDMREDQQDYSFSEQNVSQEMSEEGWRALAKIVRDVNPNLSPDEELGDLAAAEAAVNAKDAERTEIVDKLRDELRQLSRQHSQAAAAAQRPPSHPSPAEHEANVRSLEQQQFSIAKQLNEEQAAVAKKEVELGKWKTAKEDIEKVEIGEGDWADGKVIRLKLFSEAGFSLVSAKDGSNVTKVLIRNDAKEDVHSVVVDNSRPKVYTANLIWSLASD
The following text describes a protein:
Function:
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (By similarity).
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Lipid droplet. Note=Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone.
Sequence:
MASFVTEVLAHSGSLEKEDLGTRISRLTRRVEEIKGEVCNMISKKYSEFLPTMQSAQALVTQVDTLSNDIDQLKSRIETEVCRDLHISTVEFTNLKQRLERDSVVLNLLKQLQEFSSAIEEYNSALAEKKYIPAARLLEEAQECLKLLKSKKCFDLKMLKSLSMELTVQKQNILYHLGEDWQKLVVWKFPPSKDTSSLESCLQTELHLCTEQPEKEMTPLPSISSVLLAFSILGELPTKLKSFGQMLLKYILKPLVTCPSLHAVIERQPNSVSICFQSLATDSEHPPPPEAFAKIQLVLEVLQKQLLDLPLDADLEIGKVPEIVLAEMLGEVIWEDLSDCLIRNCLVYSIPTNSSKLQQYEEIIQSTEEFEKSLKEMRFLKGDTTDLLKYARNINSHFANKKCQDVIVAARHLMTSEIHNTVKIGPDCEETLPDLPSPDADHRLQVQVCKVQFTDAGNLEPETSLDPRSFSLPTCRISEAVKKLMELAYQTLLEATTSSDQCAVQLFYSVRNIFHLFHDVVPTYHKENLQKLPQLAAIHHNNCMYIAHHLLTLGHQFRSRLTPILCDGTTTFVDLVPGFRRLGTECFLAQMRTQKGELLERLSSARSFANMDDEENYSAASKAVRQVLHQLKRLGIVWQDVLPVNIYCKAMGTLLNTVIAEMIGRITALEDISTEDGDRLYSLCKTVMDEGPQVFAPLSDENKNKKYQEEVPVYVSKWMPFKELMIMLQASLQEIGDRWADGKGPLATAFPSSEVKALIRALFQNTERRAAALAKIK
The following text describes a protein:
Function:
Possesses in vitro carboxypeptidase activity against the C-terminal arginine and lysine residues. Involved in the maturation of CLE19. Removes the C-terminal arginine residue of CLE19 proprotein. The cleavage of the C-terminal arginine residue is necessary for CLE19 activity in vivo. Is not involved in generating active CLV3. Is not involved in CLE19 or CLV3 perception.
Subcellular Localization:
Endosome membrane; Single-pass type I membrane protein.
Sequence:
MSKLRFFQSLLISTVICFFLPSINARGGHSDHIHPGDGNYSFHGIVRHLFAQEEPTPSLELTRGYMTNDDLEKAMKDFTKRCSKISRLYSIGKSVNGFPLWVIEISDRPGEIEAEPAFKYIGNVHGDEPVGRELLLRLANWICDNYKKDPLAQMIVENVHLHIMPSLNPDGFSIRKRNNANNVDLNRDFPDQFFPFNDDLNLRQPETKAIMTWLRDIRFTASATLHGGALVANFPWDGTEDKRKYYYACPDDETFRFLARIYSKSHRNMSLSKEFEEGITNGASWYPIYGGMQDWNYIYGGCFELTLEISDNKWPKASELSTIWDYNRKSMLNLVASLVKTGVHGRIFSLDKGKPLPGLVVVKGINYTVKAHQTYADYHRLLVPGQKYEVTASSPGYKSKTTTVWLGENAVTADFILIPETSSRGNQLRSSCDCSCKSCGQPLLTQFFTETNNGITLTLFVVVVFLCFLLQRRVRFNLWKQRQSSRRSITV
The following text describes a protein:
Function:
Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (By similarity). Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (By similarity). Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation.
Subcellular Localization:
Late endosome membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein.
Sequence:
METAVIGMVAVLFVITMAITCILCYFSYDSHTQDPERSSRRSFTVATFHQEASLFTGPALQSRPLPRPQNFWTVV
The following text describes a protein:
Function:
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Sequence:
MAPKSRLSQRKAARGTPVLTAGSDTTSASKSSKSKRVKKSAVSLKVETPDNKPFRGTRRSPRITQKVKVSLTSSRIEVLKENVKRGQKVKKVKKEQMEEEEEEEEEEEEEEEEEMMVDIKPLKEEPDSEMSDGEELETPGLSEYEKRRLENISKNADFFASLDIFKAKENFLALTPQAQKPKRQTRGLKSQKRESAPVERRPRSLRIQNKSPDGAELPENFREPTYTPYVSDVRSRERLPSDPVKMDATNVKKEEKTDAGTDFVEGLAALARGEKTSVATDDKDLNKFASKLQEMKMKPRYMAKVVPDRIFSVAVHPSVDKTVVVAGDKWGKIGLWDVNSTEGDDGVFLFAPHTRPVNCLRFSPSDPNKLYSVSYDGTVRCGDFAKAVFDEVYVADEDEVIWTNFFDFMSADGSSLLVTQNDRTGNVVVVDTRSRKGGENVYHVHSRNAKTVSVHPTMPNYFVTASTDRTAALWDIRSMKSKGTINQLPRCLILNPSARHSSHRSLVQRSLLHLWMTKSASLTLRVLRRVN
The following text describes a protein:
Function:
Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
IGGTHWPHPGPGACDCRPHLSPGQRPAPAWERGCGVPAVTEVSLRRQRPPPRPPPRAPRAPAVQTRERAPLGRAVPGLPGAEPRSLRPQALGALRAPSAAVAQPARLSARAPARPAAAASCTRPRAILQPKSLAQESAPPPPRRARGQDAPHPGPEGGRENGGRGGPREQREPEVGGQRGARDGRPGGALAPALSLCPAASRLFIVAGKRRPPGTRNNKARSPQLEPRGLLATGRAGVPWRLGSAPASSSSSSSSFSFASAATGSSAAAASSAAAPSSHGCDLRGGKPSFPATPMDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MSNSLSDNIILILSGEYPSSLPSQVILEIFENIPFEKVKEQCAPLVHSYCCRHVWGNDSKAFLYRCKTCETGPNSCICVECFQNGNHEGHEYYMQKSGSGGTCDCGSSISWKASGFCKYHGHHFEGNLYEITPEPWKSKFDEKMELLLTLLVEKLQIIFEKFHQGETIQQLEQYGILSIIKILRKCCEIDLFQFHVTELMKTNKQNYYCRMTLLDKNRKIGIDEFLIDMSMIDCEVFVDELSLFVMELLTNDKNTDRLYESFMDDLIYIMNNESPSNCMNDVFTKLTCQFTSCKQFNEKYFFGNVARSVSFIGVISKYFRQDAPTISLDSPKIISMNYYTTELSTIVTSNPSKLFSIPMLYQEYIRCLESIMFYHEELRELHQHVQYENLCDYSPFYCKEVLLGIGFTCLKSLSKEQLLNVIQDVTKRYLKLYNIHVKCSHPDVGINQPISMYYPLLTFLVYAISLTDSPFETFQTLPSPNLLLTYPIIFHQFLTELSYDQLWARNGQSVMLKTICCLPQYPEQLMSDTFLLQLASYKTEELLQLMIPLCKIDRIDEVIAKQKEISNECPKSVPSEIVAGSISLLKIINNMFSDPMLSNKLSQKQEIIYLFIHCLASRQTNASDIKKSIPSNVDGLRDMDIEEIFSEIVDIKQKKCYLKEEYWKYINPYCPYINSVNREVVCEEYSKKMNKSLPCIYQIEKRDPTLESCLLHLLHSPIVSDLCCKLIVGCHECKVVSLVEHLLRLRAAYHEGITYDNYHKNILTNLGEILANHREWKDASTIKLCKGTLLEDVFKGYESINGKEVKQSNDSKSKKLALLKKMAQKRDNFQKVSIVDIEKEEVEEDTKKEGCIICRSCEDSENDPLGFLGHIEATDAIRSAEYAESVEGVRGETKEECWKKPLGLIEGEWKWKPKRNNNWDVTKDDQEYRVLSSCPHKIHLECYLKDYEDSGNEENYYLSKSVYCPLCHTISNVFIEEHQPISIKLEDPSFEGIDSVINQCINSIPESVSSFNKSVNHTLSRTLTATVRFGIQNPVECSFLSMTSVVASTVMSLEIQMRSSRPTRYEHQLNTLYSYLQVIKKIAANLSIQFRKDVLEQICKFTSARSPILQLLRCYILFPEHWSTFLALADMHELLAIYSEIQQFSKFTPPVNCNTIVKESELPQYSKYSTENQLVDALAQTYLRRIAILKDVLTVSPEPLKTHYDFPIHETLKVLNEKNCQCVGYIQRPTIPQPFKFISLPSTYQQLINEVLKTRCCVCGIEASKIIYNCAICMTCGCLLCYKDKKHQDIIHSERPVYEHMIKCSGEVGIFLVVHSAILIIMTPKMHAQINGIYVDRFGESPDSSYLTKEMYGLNTQLLEKIERFYLTGEVSSSPELNFYVPKFH
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MTTPFSDRAPAKIQQETSPPTLHHKTLSAYYPYIYTLSKFISSRLEGFESQPQASNTTAFSTFLKTTLCAFRNEDELNRVELDKDRRVIFPTQQEAIDKALSHVAKASSGPGKVQNLLLFRTSSKLHIQDLPINMSRPSVPNQTIQGPAGVFRSSEWQILRSRIGDKSFSQLLLGTSLFSPVGNNCYLQLSGIPLYELYEDDHRRAFSKIELSRKRKRGAEKNRKGKRKRPKSTTVIQAEESSEIFDQAKAKEKKDDGNPSNISIQRQRMFYGRPYWHKQGVLSHGLPPSHILNSLKCGKKSHEAPSDFDCLSLLDDIFPQLVGNNKDISTLTTEKLPKRAAGMIGIAREIIVRHSRLEYEDIMKQCLKRMDRVSSKTPPTYTEKSAWTATPAQSNEQTLPTSAVRRERSARVNIAIYEEKTHNPFMPKTHRQVCWFVTTIVRSLFSTQIMGSQHNLDILLANVRRFITAKQFETISLHSLSQDLRINDFRWLHENIGSGQRVSPGEMKKRKELVLSLIHWIFECFLVPLIKNSFYVTETATTKYETVYYSQKDWNKAVRPHYRKLQDNLLEEIDKNKVEAARRGVLGVSTARLIPKPTGFRPIVNLGRKIETPDTTNSKRKSWSANQILGNVHKVLTSEKDRQKPRLGGALFGTNEIFPPLQKLKCDLTKKHGNLPQLYFIKTDIKAAFDSIKQDKMLEMLEDMLRQSSEYRVILYSVLLPPGHKAYQGTSKRFFKSRAIPTEDVSLTFADHAKEIAASMRNATIVDMVRRYSVTTQECLDLLRTHIKDNVWQVGKQYYRQKTGIPQGSKVSTLLCTMFYSYLENEHLSWTRREGSLLLRYIDDFLFITDNYNLARRFVDVMSRGFPEYGARISVDKTLLSFEYDTGKQLAPVCGVNEQGDVDFPYCGFLIRTGTLDIMPDYTKFLNYSIKQSFARRSTRKQGSTFLTWYSRQLENRNHVALLDTAHNGLGTVMMNVFINFAITTMKVPHYFKGTDTGANFNRLVFASMLCSSEYTFYAGRARVLHHVRTKNSKNLDKKEHFSLKKEEFILLAITAMSHVLKRKASRFRGVVDLLEAEGKKRVYRGLAGKLAVVCDKGWDAVKDAKY
The following text describes a protein:
Function:
Promotes the proper distribution of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2) synthesis at the cell membrane. May bind phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2) and is required for robust anchoring of the contractile ring to the cell membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Note=Localizes to cell membrane-endoplasmic reticulum contact sites in a manner dependent on the VAMP-associated proteins (VAPs) scs2 and scs22. Less abundant at the cell tips during interphase; during cytokinesis it relocalizes towards the cell ends and is excluded from the medial region.
Sequence:
MKLKVSIGCDAQHTQIAWVNYEGRPTEVDGPLWVGRILVRVRDFDGFTPDGSPPKRDSEYFRGRSRKFQIQAEGRFKKEYNGDQVIYGTQFDHMISTFPESAFRAGMRIAKYIDPAVYYDKYARSPYIMSPFVACVNTLSAWPAPSRLEDAVISLVEADSQESDTESLPEINDSSDVSLSDLPSTNVTPKKTTTQIDVQTNIVTPPITVTAVPDSPNPPAATPATVADNDDLSIVSSDSGNTTAPRKNRHRYWSFAGFSDSTRFSHLNVPAAIPDAPSVKTETSQNVSQLSVKSAATSLAPVEDDEDDELLLHRHITNKHKDFNLHVKQLGLLHKPSLDLEEGYIMDENYGKDVYKHGISNVPDDENEDDLQRYFTALEMQQDQKEQHKKSKNKDPFRKITHPSLHLGKFSTPKLIKRMSLRSKKSLRNDSKSDDVGNSTHRFSTASAASTSAVKTEKEKKMSAPRRSLDKLIRIGSLHRHHHHHHKTDLIESDSGIEASESNRRKSDIFSFSGRNSFSVSRPSSSHSTLSYANDSASSAVNVAGETGSLPPLREQTSITSGVPPSNRLKKHVSTPEKIVEERSIDEVSQSNTPSSKQLPQSVDGKTVTANANSTTVAKQPTSNVALTRPKPVRTATSQSKIPKPVKHIPSDSNNLDPQLGPWRFANPKVDPIEDNSFIFGEHKSVKERRKYFSSSKFCRENFFYDKDVVYCMSFFSPHMDFNTFNLNIGPIRLNVYKHLNSDGHQPIRYMMRETDDEDAVMFVVEFDLLEDDDETVLAEQAKERERRKQT