lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction (By similarity). Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage.
Sequence:
MRLLVTGGAGFIGTNFVHSAVREHPDDAVTVLDALTYAGRRESLADVEDAIRLVQGDITDAELVSQLVAESDAVVHFAAESHVDNALDNPEPFLHTNVIGTFTILEAVRRHGVRLHHISTDEVYGDLELDDRARFTESTPYNPSSPYSATKAGADMLVRAWVRSYGVRATISNCSNNYGPYQHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVRRILDRGRIGRTYLISSEGERDNLTVLRTLLRLMDRDPDDFDHVTDRVGHDLRYAIDPSTLYDELCWAPKHTDFEEGLRTTIDWYRDNESWWRPLKDATEARYQERGQ
The following text describes a protein:
Function:
Converts 3,5-dienoyl-CoAs to the corresponding 2,4-dienoyl-CoAs. Involved in degradation of unsaturated fatty acids.
Subcellular Localization:
Peroxisome.
Sequence:
MTMESYKTLEIIRKNTDSSVFHLIINRPSHLNALSLDFFIEFPKALSSLDQNPDVSVIILSGAGKHFCSGIDLNSLSSISTQSSSGNDRGRSSEQLRRKIKSMQAAITAIEQCRKPVIAAIHGACIGGGVDLITACDIRYCSEDAFFSIKEVDLAIVADLGTLQRLPSIVGYANAMELALTARRFSGSEAKDLGLVSKVFGSKSELDNGVTTIAEGIGGKSPLAVTGTKAVLLRSREVSVEQGLDYVATWNSAMLISDDLNEAVSAQMMKRKPRFAKL
The following text describes a protein:
Function:
[Protein hedgehog N-product]: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development; [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
Subcellular Localization:
[Sonic hedgehog protein]: Endoplasmic reticulum membrane. Golgi apparatus membrane; [Protein hedgehog N-product]: Cell membrane; Lipid-anchor.
Sequence:
MLEDLDSVQARLSPDNVNSTQDCCNENGSRTPAASCNQTVLQRFTNLICTCNLRRRQLQRLCFSTRKHKSHRSGAGYCTLLPTCASIRVHIAGFLAWTLLVAPLLSGIAMDTRLLRRRSSLGGVSMCGACRPGHGSGGSRMPGRELVPFLKGEYVPKMSEQTIGASGPVTGRIRADTPRFRQELVPNWNTDIEFRDEEESNEDRFMTPICRARLDYLAILVANQWARVKLKVLEAWDDGNDKANDPLHYEGRAVDITTDDADRNKYPILARLAVVAGFDWVKYDGKVVHCSVKSEESDAAKYGGCFPGESTVIVPGEGHVPISSLQPGDQVLAIDKSGAVITDTFLSFMDARSDIVSGHQAYRQMVEITTENGFSVTLTRNHLIYVSKPTYDASLLTATSNATQQNNERLGLQDFTSPHSSFAAKVRQGDYIYTLPNSHTGPDTPSATVRPSRVVSVRTIETASGAYAPLTYSGTIIVGGTAASCYAVIESDVIAHTVVSPFRYYHWLSLWFNGDSKDHRNCTHVGPVRPTDGISLYSKLLHQIFSKVLPSWFFWAE
The following text describes a protein:
Function:
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity).
Sequence:
MLELIEVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRISQHGGSSTSLSSTKVCSSMDENDGPGEEESDEGFQIPATITERYKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFNTGPKPSSTAAGVSVIATTALDKERQVFRRRRNQDVRGRYKAQPAPPELNSESEDYSPSSSETVRSPNSPF
The following text describes a protein:
Function:
Possesses E3 ubiquitin-protein ligase activity.
Subcellular Localization:
Plastid, chloroplast outer membrane; Multi-pass membrane protein.
Sequence:
MIHLAGFTCCLGGVALYLLTRSTGRDIKSITRVYQLKDLEQLVEVESKVVPLIIAVSGDVGSETPIKCEHSYVLGVFLKRTAEQQVLRRNWRFSWVRNSTLMQPMTKEVPWYLDDGTGRVNVDVSQGELGLALTVGSDVFEKAEPVSLVQGALGYLKGFKILGVRHVERVVPIGTPLTVVGEAVRDGMGNVRIQKPEQGPFYVTYIPLDQLISKLGDLSRRFKYASMGLTVLGVILISKPVIEYILKRIEDTLERRRRQFALKRVVDAAARRAKPVTGGGTSRDGDTPDLCVVCLDQKYNTAFVECGHMCCCTPCSLQLRTCPLCRERIQQVLKIYRH
The following text describes a protein:
Function:
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
Sequence:
MAWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI
The following text describes a protein:
Function:
Probably acts downstream of the Wnt signaling pathway.
Subcellular Localization:
Nucleus. Secreted.
Sequence:
MKIALYSILLITVCYLSSTDAYLFDPKAVDALLREIRARLQATGKEPHARKIEQETEEIKKEELMQAEDVEGSGSGEEIEGSGEVISTITGVPIMDNEEKKDLKPENFPRPEPIFDKYGNLKSKDKLEALTYSNFKKQAPATLQDHYNLNPTGTLQMLQGLDIHGGSGGYHRALSGGYLPPSTYDPYNVNWHSYGDEGVKMKDKAISVFRRVIAPGR
The following text describes a protein:
Function:
Transcription factor involved in the regulation of osmotic stress responses and stomatal movement. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Positive regulator of EDS1-dependent defense against E.amylovora. Together with WRKY70 and WRKY53, promotes resistance to P.syringae, probably by enhancing salicylic acid (SA)- dependent genes. Contributes to the suppression of jasmonic acid (MeJA)-induced expression of PDF1.2. Together with WRKY54 and WRKY70, promotes brassinosteroid (BR)-regulated plant growth but prevent drought response by modulating gene expression.
Subcellular Localization:
Nucleus.
Sequence:
MMMEEKLVINELELGKELANRLMNNLKHTSSVDSNKTLISDILRIYQNAIFMLSFNQDKNILKRSLEIDGKDSKNVFKKRKVSEKNTEKVKVFVATEQENGSIDDGHCWRKYGQKEIHGSKNPRAYYRCTHRFTQDCLAVKQVQKSDTDPSLFEVKYLGNHTCNNITSPKTTTNFSVSLTNTNIFEGNRVHVTEQSEDMKPTKSEEVMISLEDLENKKNIFRTFSFSNHEIENGVWKSNLFLGNFVEDLSPATSGSAITSEVLSAPAAVENSETADSYFSSLDNIIDFGQDWLWS
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MRFSAVAGRYARALLNVAIEKEKEEEYLRFLDLVCQIYESSRELFDNPILKPEKKISLIKEIMKSFGQEMDEFQERFLTLVFERKRQKLLRNIRDLFEYEKILSEQKVPANLSIAHSPEDEELSLLRKFVRKYALKDPVFDISIDESLIAGALVEFEGFRLDTTVQGRLKRIAREALKRGEMS
The following text describes a protein:
Function:
Regulates the ribonucleotide reductase activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSETFKLPDHDELPQLVQTTLFDVGARVRKAVQTGYKFDQQLFPSYHKDQTDRNELPQQKHDPNLRLDDLKQELAADSIFWDTASTQEIADSFAKPDFLKSH
The following text describes a protein:
Function:
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
Sequence:
MYKQGEPNLWTGRLDSETDPKKFRHFQTVTFEDLSKLEKSSMPSGVGILGYAVDKGVALNKGRIGAKEGPDAIKQAFAGLPDLNQCETLVDYGNVYHDHEELIDTQKEFAMLAAKSIANHRQTFLLGGGHDIAYAQYLATRKVYPTQSIGVINIDAHFDTRAEQQSTSGTSFRQILEEDENTDYLVLGIAQGGNTQSLFDYAKEKKIDYVFADELLSHVSPTIKDMIERFVHEHDVIMFTICMDVIDSAFAPGVSAPAVLGLYPHTVLELAKRIIPSDKVSSVSIAEMNPTYDADNRTAKLVANLVHHFLK
The following text describes a protein:
Function:
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (By similarity). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (By similarity). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (By similarity). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (By similarity). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Chromosome, telomere. Note=Localizes to DNA double-strand breaks (DSBs).
Domain:
The zinc-hook, which separates the large intramolecular coiled coil regions, contains 2 Cys residues that coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another RAD50 molecule, thereby forming a V-shaped homodimer. The two heads of the homodimer, which constitute the ATP-binding domain, interact with the MRE11 homodimer.
Sequence:
MSSIESLSIQGIRSFGTYADDLQSIKFSSPVTLILGENGCGKTTVVECLKYALTGECPPGSDRGKSFVHDPKIFGLNEVLAQIKMQVRDRRGAQVSICRTMKVSKKRNKMSFETMDSTINFLTGAGQSKREKQDSLSGRSVDIDVAISDFMGVSKAIINNVLFCHQEDSSWPLDESKKLKEKFDAIFGITEYNKALDKIIKLRKEAMEELKIKEANIKHVAYLKQEMEVKTLNLQKAQRKCDAIKAQCSECEEEMKPIEARLVEIRNVEFEIGKYQAQKVEMDTKHKNCKDQISTLTLKIKKPFRGTLDELDQEISNFDQRMLEMRQKRTEVEGDLSQIKRSSVAEQEKLGTQDRKHCLAKQRHQSELACRAQLLKRVKEFCRELHIPIDCDLVEQPEKMGEVLRDIEAMIITKHCEITEIVEQNEKADRSRQVKIDELRIELTKSEQSVTAQEKQRESSKRESETLGVEIKKIETSMQDLKKLEKEINEVNELYESATKNIDQQAIKDAIARKKASIAENQIQFKKLDEQLTFLGSMAKLVAECSLKQKELDKKNQEVHRVRSRHSDHFGKLFKEPITCNYRRSMQVVYEKLRREIQELNEKANTQKLKEQSYEIKRKNLISDISRMEKELKDSEELIYQKCRSTPYDDLLERSKTTISKLQFDHGALKSSEALYKKYIQKMDEEPSCPLCHHNMTSDEACDLTSELTDEIQKLPDNITRAEKALKAEQIKYENLLQLKPTILKVKELKDSLPQKKEELKKVEELLGDSVSEYETLIALIGEPTHNMELANSMMGDMSLLDEALKDSARLTKDLDLQKGQLPASYDSSVSMDDLQAEKSKVSKELETERKELESAQNAVQQQMDALNRLREKKNSLKDRQIHLREGLQSLPQLKERLEKLNSFLTTVASEISELKAKIQPLKLNLRAAIEEKERLKKSESEKLAQLNSKYNSYKSTDHDIQRLNKEAEDYAKLDLRNEIKKLDEIIMASKDKLRKLEAEISLKTDELETIKTECSNQQTVERDLKDNRELKQLEDKEAKLRESCQVLDKQLGNLDFHSVSKEKVNLTKQRDKATVRKGELLGQLGEIHSQVNKLQREIDEPRFKESLKNFRKANYEIEVTRLCIEDLGQYRLALEWALIQFHSEKMEMINRLIREYWRKIYRGNDIDYIQVKTDEVSSDASADRRKTYNYRVVQSKNYSEIEMRGRCSAGQRVLASLIIRLALAETFSSNCGVLALDEPTTNLDRANINSLCEALNCIVEERQSQSNFMLIIITHDENFVSSLGKITSYHRVFRNEECKSVIRRVEAGPSKKALIDQ
The following text describes a protein:
Function:
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MDPNNREKDDRPRPAKALPVRTGHSSRPSSSTTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGNTAEGLPQVFYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHIIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPVEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRTLFSELFERKGYTFDCVYDWVGRPIPTPGGSVHVDSGTSAITRESHAHRERPSQTQPLRNQTGVPDRRGAWDLQVGRQAHPAYLVPHLASDRHGGSVQVMSSTNGQLNADDQTGGHSNAPITAQAEVEVVEEAKCCCFFKRKRKNHSQRHHK
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MRRPAGVGARWALALALALATASCSCVTHGARTTPSSGADVLRPGGEATPSGTAGQDDYRGQAASPSNQQKREGEGQQGMMTLKERAVTGSRLPDCAHACGACAPCKRVMVSFRCAEASESCPIAYRCMCHGRFFRVPAL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSGEATVLAYHAPEEQEGLLVVKVEEENYVLDQDFGLQENPWSQEVFRQKFRQFSYSDSTGPREALSRLRELCCQWLRPEVHSKEQILELLMLEQFLAILPEELQAWLREHRPENGEEAVTMLEELEKELEEPRQQDTTHGQEMFWQEMTSTGALKSLSLNSPVQPLENQCKTETQESQAFQERDGRMVAGKVLMAKQEIVECVASAAMISLGKLPGETHSQQIAEEALGGLDNSKKQKGNAAGNKISQLPSQDRHFSLATFNRRIPTEHSVLESHESEGSFSMNSNDITQQSVHTREKLYECFDCGKAFCQSSKLIRHQRIHTGERPYACKECGKAFSLSSDLVRHQRIHSGEKPYECCECGKAFRGSSELIRHRRIHTGEKPYECGECGKAFSRSSALIQHKKIHTGDKGYECIACGKAFGRSSILIEHQRIHTGEKPYECNECGKSFNQSSALTQHQRIHTGEKPYECSECRKTFRHRSGLMQHQRTHTRV
The following text describes a protein:
Function:
Degrades oligopeptides in a sequential manner.
Subcellular Localization:
Cytoplasm.
Sequence:
MLSLLIIRATQFAITSFRCESTIYRYCAKYYYIGFHNHKDLIGVKEFCGKHYILKIIHYHMKAYYMYPDIRGDLISFTSDDDVWLLSLKDMKPLRITSGLGVSTRPKISPSGRKVAFSVIWLKSGKQGGDIYVVEDGQARRVTYFGSRNSRVAGWISEDEIIVITDFHTPFIQWTEAYKVNVNNGKTEKLPFGMLSNIVIKDDIIVIARGYQDLPNWKGYKGGTKGELWISSDGGKTFEKFVSLDGNVSWPMIVRERVYFLSDHEGVGNLYSVDLKGKDLRRHTNFTDYYCRNASSDGKRIVFQNAGDIYLYDPEKDSLTKLDINLPTDRKKKQPKFVNVMEYMNEAVVNGNYIALVSRGKVFLMRPWDGPSVQLGKKQGVKYRQIQVLPNGDVIGVNDEDKLVILGKDGSEKVINKDFSRIERVKVSPDGKKVLLSNNKLELWVYEIDNDNARLIDKSEYDLILEFDWHPNAEWFAYAFPEGYYTQSIKLAHIDGKVVRITTPYGYDFSPSFDPDGRYLYFLAARHLDPTNDKVIFNLSFQRVVKPYLVVLGNYYSPFNQPLDEANSNDKNVIIEGIEDRVVPFPIEEENYVQIAGAKNNKIFLFSYPIRGLRSQTGDVFGRLEVYDLENKAKELYADNVSSFSLSSDKSKILLILKDSLRLFDVNVKPDFNSTGRKGGVIDLSRVKVYVEPEKEWRQMLRETWKLMKQNYWNEERLKNWDSILPKYERLLDRISTRFELSDVIQEMQGETRTSHSYETAYDYDTPEPLSVGGLGAEFEYDESNKCYKITKIYVGDSTNENERSPLRDPGVQLNVGDCIKNIDGEDANGNIYSHLINKDQVILDVITADGKNKRVTVKVLKDERFLIYRYWVEKNREYVHEKSKGRLGYIHIPDMMYQGFAEFYRLFMSEFHREGLVVDVRFNRGGFVSGLLLEKLLLKRVGYDYPRNGKPIPMPYFSSPKVLVGITNEHAGSDGDIFSFLFKKYKLGVLIGRRTWGGVVGIRPRYRLVDKTYISQPEFAVNFEDVGFGIENYGVDPDIVVEIKPDDYVNNRDTQLDTAIELALKQL
The following text describes a protein:
Function:
ADP-ribosyltransferase that regulates transcription by ADP-ribosylation of host ribosomal protein S1. Additional identified targets include proteins involved in either translation or cellular metabolism such as elongation factor-Tu or trigger factor. Also reprograms the host's gene-expression system by RNAylating host ribosomal protein S1. ModB can attach NAD-capped RNAs to target proteins post-transcriptionally resulting in covalent RNA-protein conjugates.
Subcellular Localization:
Virion. Note=This protein is injected from the virion into the bacterial cell.
Sequence:
MIINLADVEQLSIKAESVDFQYDMYKKVCEKFTDFEQSVLWQCMEAKKNEALHKHLNEIIKKHLTKSPYQLYRGISKSTKELIKDLQVGEVFSTNRVDSFTTSLHTACSFSYAEYFTETILRLKTDKAFNYSDHISDIILSSPNTEFKYTYEDTDGLDSERTDNLMMIVREQEWMIPIGKYKITSISKEKLHDSFGTFKVYDIEVVE
The following text describes a protein:
Function:
Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase (By similarity). Required for normal assembly of the central element of the synaptonemal complexes (By similarity). Required for normal centromere pairing during meiosis (By similarity). Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Chromosome, centromere. Note=In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Found only where the chromosome cores are synapsed. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex. Only rarely detected at centromeres during leptotene and zygotene. Detected at centromeres during mid-diplotene, when it is no longer present along chromosome arms. No longer detected at centromeres at later stages of meiosis (By similarity).
Domain:
The molecule is in a coiled coil structure that is formed by 4 polypeptide chains. The N-terminal and C-terminal regions exhibit a prominent seven-residues periodicity.
Sequence:
IVELQFEKEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETSARSAEKTNKYEYEREETRQVYVDLNNNIEKMILAFEELRVQAENARLDMHFKLKEDHEKIQHLQEEYKKEVNDKENQVSLLLIQRTEKENKMKDLTFLLEESRDKVNQLEDKTKLQDENVKELNKKKDHLTSELEDTKMSLQRSMNTQKALEEDLQIATKTIYQLTEEKEAQMEEFNKAKTDHSFMVTELKATTCTLEELLRTEQQRLVKNEDQLKILTMELQKKSNELDEMTKFKNNNEVKLEELKKILAEDQKLLDEKKQVEKLAEELQGKEQELTLLLQTREKEVHDLEEQLLVTKISDQNYSKQVEELKTKLEEEKLKNAELTASCGKLSLENNKLTQETNDMALELKKYQEDITNSKKQEERMLKQIENLEEKETHLRDELESVRKEFIQQGNEVKCKLDKSEENARSIECEVLKKEKQMKILENKCNNLRKQAENKSKYIEELHQENKALKKKSSAESKQLNAYEIKVNKLQLELESAKQKFQEMTDNYQKEIEVKKISEEKLLGEVEKAKAMVDEAVKLQKEIDLRCQHKIAEMVALMEKHKHQYDKIVEERDSELGLCKNREQEQLSVKTALETELSNIRNELVSLKKQLEIEREEKEKLKLEKENTAILKDKKDKKIQTSLLESAETTCQKFDSKTTPSQNISRISSSMESGKTKDNRDCLRTSAKILSTAFVKEYTVKTPTKMQMYQRENKYIPTGRSNKKRKTVFEFDVNSDSSETTDLLSMVSEEEISNRLYNNNSPNSHLTPKQTPLSLSTPESFVSLGGVRKMREDRWATIAKTDRKRRLKEAEKLFA
The following text describes a protein:
Function:
Vacuolar amino acid transporter involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine. Required for sporulation.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MSGYSPLSSGPADVHIGKAGFFSSVINLANTILGAGILSLPNAFTKTGLLFGCLTIVFSAFASFLGLYFVSQCAARLPRGKASFAAVAKHTFPSLAVVFDASIAVKCFGVAVSYLVIVGDLMPQIAPSLGLSSPMFLRRQTWIVFALFVLTPLSFLKRLDSLRHTSVISLIALCYLVFIVLYHFIIGDTVKGEIRYFVPESGFGYLSVLPVFVFGFTCHQNAFSVINEVRNFSQGFVNFTMFTAIISSTLLYLLVAITGYLSFGSLASGNIIAMYDNTSIWIIGGKLAIVVLVLFSYPLQCHPCRNSVYQAIRRSYSAHDMSDGYHAVITLCILLFTHSLALLLSSLEMVLAFVGSTGSTFISFILPGSLYYFFSHKVASPGNSSPLQLRISRAFAAGLAIYGTVVMILCLNINIAKLSH
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes; Regulates also the sphingolipid metabolism.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MASEYRCVGCGFRVKSLFIQYSPGNIRLMKCGNCKEVADEYIECERMIIFIDLVLHRPKVYRHVLYNEINQETVNIQHLLWKLVFAYLLLDSYRSLLLRGTNEHSSLVLVTVKVLVDVLSTNLAFLFSFAIAAKGLLHEVSRKREILLGILISSYFKMFLLAMLVWEFPVSVIFIIDMLVLTSNSMALKVMTESTTSRCIAVCLIAHTVRFLVGQIIEPTTFFTQFGSLVYLSSLFRIL
The following text describes a protein:
Function:
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Subcellular Localization:
Cytoplasm.
Sequence:
MYPITLPLSHSKLSFPSIKPFSTPSNNLSTATSYVSFRSFASTSESLIASTTTTAVAVTTIQTANLSDPDATANATAFVIHARNRIGLLQVITRVFKLLGLRIEKATVELEGDHFAKTFYVTDSHGNRIEDAESLDKIKKALIDAIDGGDEANEVKKVGCTQRGVAVRRRLGSSSEGKAKVDRMFGLMDRFLENDPSSLQKDILDHALAHSVRDRLIERWHDTQIYFKRKDPKRIYFLSLEYLMGRSLSNSVINLGVRDQYADALSQLGFEFEVLQEQEGDAALGNGGLARLSACQMDSLATLDYPAWGYGLRYQYGLFRQVILDGYQHEQPDYWLNFGNPWEIERVHVTYPVKFYGTVEEEGFNGGKRQVWVPKETVEAVAYDNPIPGYGTRNTITLRLWSAKPSDQNDMESFNTGDYINAVVNRQRAETISSVLYPDDRSYQAWLFLFYWSVTAYALNLIVEVMRVLVDEEHISWNRSWDIVCKIFSFTTHTVSPAGLEKIPVDLLESLLPRHLQIIYDINFNFIEELKKRIGLDYDRLSRMSIVEEGAVKSIRMANLSIVCSHSVNGVSKVHAELLKTRVFKDFYELWPQKFDYKTNGVTQRRWIVVSNPSLCVLISKWLGTEAWIRDVDLLAGLQDYVTNADLHQEWNMVRKVNKTRLAEYIEAMSGIKVSVDAMFDVQIKRIHEYKRQLLNILGIIHRYDCIKNMEKNDRRNVVPRVCIIGGKAAPGYEMAKKIIKLCHAVAEKINNDPDVGDLMKLIFIPDYNVSVAELVIPGADLSQHISTSGHEASGTSSMKFLMNGCLLLATADGSTVEIIEEIGKDNVFLFGAKIHEVPVLREKGSALKVPLQFARVVRMVRNGYFGFEDYFKSLCDSVENGNDFYLLGCDFESYLEAQAAADKAYVDQEKWTRMSILSTAGSGRFSSDRTIEEYADRSWGIEPCRCPF
The following text describes a protein:
Function:
ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MARHGDTRSPSPVGSTYSSSRRSRRDDDRYERKRDDGRSYRRSRSPERRYRERDRDRDSYRRRDHSVDRRDSHRDEDNYRRRDRSRDRRRSRDRDHDRDYRRRSRSRDRDYRSRRDDSRDRVRRRTDDSADLKRKSRRDDSRDRTRGAEPKSREASTPAIPTRTGPTDDEKRAERLAKLEAWKQKQAAEKERKQKEAEASGGPRNILEEIDRKSGLSPAVSSPQSPATQGVDAAPAAYAGKFDPKAIAKNAAQTPAAPSVLGNDVAVPSSAKTSNAQTARVQASKASGNAPSPAVLKAKGNVGSFGLGTKQVADNEKSIATKTLGFGEEESTRRKLERLPTPPLDDADASKTAETNADDDDDVDMQDGETEEDAAAAARVAAERREERLQNESLTKTTNGNTTAKAEEADKMEVDAQEEELDPLDAFMSELAESAPPKKKAGAKFSKAQEPEAIFGDEHDVSMTAVGEGDAEDFLAIASKAKKKKDIPTVDHNKVEYEPFRRKFYTEPSDLAQMSEEEAANLRLELDGIKVRGLDVPKPVQKWSQCGLGIQTLDVIDKLGFASLTSIQAQAIPAIMSGRDVIGVAKTGSGKTMAFLIPMFRHIKDQRPLENMEGPIGLIMTPTRELATQIHKDCKPFLKALNLRAVCAYGGAPIKDQIAELKRGAEIIVCTPGRMIDLLAANAGRVTNLRRVTYVVLDEADRMFDMGFEPQVMKILSNVRPDRQTVLFSATFPRNMEALARKTLTKPIEIVVGGRSVVAPEITQIVEVCNEEKKFVRLLELLGNLYSTDENEDARSLIFVDRQEAADTLLRELMRKGYPCMSIHGGKDQIDRDSTIEDFKAGIFPVLIATSVAARGLDVKQLKLVVNYDAPNHLEDYVHRAGRTGRAGNTGTAVTFLTEDQERYSVDIAKALKQSGQEVPEAVQKLVDSFLEKVKAGKEKASNSGFGGKGLERLDQERDAARMRERRTYKTGEEGEDEEEKDEKKNEQAEEQFNKVLSAVQSTSAQLPGVPKGIDLDGKITVHKREVDPNAPNNPLDKVGSAVADIHARLSRAGVMRSGVPIDNRGPDAGAFHATLEINDFPQKARWAVTNRTNVAKILEATGTSITTKGSFYPAGKEPGPGENPKLYILVEGETELSVTNAMRELMRLLKEGTIAAVDSESRAPASGRYSVV
The following text describes a protein:
Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
Sequence:
MKQLEFTAVHAIFKILSTSLGPKGLDKVIVNIQKSKTFEKNESQQLDTDDLIITNDGATIMKSLPISHPLGIILQQLSNSIDVCDGTTSGVILACKLLKESEKLLIRNYHPNLIIKAFTIAYEQSKLLLNSNSIELSITNDLLSNNFNIINNNNNSGSEYETIKILEQIISTSLSSKILNSYVKQFTRYCFEAISIIKEIVKHNDDNDDDDDDNGFDGDKIDKIRVFDNIQSNVKYIKLLGNNISSSKLIRGIILPLNLNYSNLISINNNNNNNEISSSPSLALTFNVVLINFDIGYIDENSFKLIQYSNLNFNKREMIENEKRQLEIKQAKEFIDNLKKQNTTCNNNNNIIIFSSKRISLSCLKLLQDNNIKTIFNLDNNQLFNIQQVTNSSVILNSITSNITKNSSSSGGSIFGNCNLNILFEKQSEYYIEIKNNNCKICTFLLKAPSIFIIEEVQRSLNDSISILSLIVESKKVIAGGGSNEIMLSVELEKFIKSDKFKELMKNEKPQDIIKYMNSIKAFSKSLEIIPKLLISNAGFDSIILFQHLKSIHNNNNNNNNNNNNNISINLENGKLCNMIDLGVIESLKGKEIMLKMIIDTVSMIIKIDQLIKN
The following text describes a protein:
Function:
Involved in the breakdown of putrescine. Catalyzes the ATP-dependent gamma-glutamylation of putrescine, producing gamma-L-glutamylputrescine. Absolutely essential to utilize putrescine as both nitrogen and carbon sources and to decrease the toxicity of putrescine, which can lead to inhibition of cell growth and protein synthesis. In vitro is also able to use several diamines, and spermidine and spermine, instead of putrescine, but with a much lower activity, and cannot catalyze the gamma-glutamylation of ornithine or GABA.
Sequence:
METNIVEVENFVQQSEERRGSAFTQEVKRYLERYPNTQYVDVLLTDLNGCFRGKRIPVSSLKKLEKGCYFPASVFAMDILGNVVEEAGLGQEMGEPDRTCVPVLGSLTPSAADPEFIGQMLLTMVDEDGAPFDVEPRNVLNRLWQQLRQRGLFPVVAVELEFYLLDRQRDAEGYLQPPCAPGTDDRNTQSQVYSVDNLNHFADVLNDIDELAQLQLIPADGAVAEASPGQFEINLYHTDNVLEACDDALALKRLVRLMAEKHKMHATFMAKPYEEHAGSGMHIHISMQNNRGENVLSDAEGEDSPLLKKMLAGMIDLMPSSMALLAPNVNSYRRFQPGMYVPTQASWGHNNRTVALRIPCGDRHNHRVEYRVAGADANPYLVMAAIFAGILHGLDNELPLQEEVEGNGLEQEGLPFPIRQSDALGEFIENDHLRRYLGERFCHVYHACKNDELLQFERLITETEIEWMLKNA
The following text describes a protein:
Function:
Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (stim1 or stim2)-dependent SOCE activity (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1-dependent manner following cytosolic Ca(2+) elevation.
Sequence:
MRVSGALFLQFLLLVVPHISCWNDEAVLLRDVQVLTLYRGRYTTARRSSPVPQLQCIGGSAGCGSFTPEVVQCYNRGSDGIDAQWECKADMDNLYRFGRVEVSCEGYNSPNDAYVLRGSCGLEYTLELTAEGKQQQGSSGFSGFASNFFQGFSNQKQQQRGGGGDGGGPYQQHSYQNSPSGDGVGGLLVVAFLLLVAFVVYKMFLCSPTNGHQGFGGDQGYDSTNGAWDNSQGMGPPPPGFKPDYYSGDHSNSRPGYGFSDSYTRPQSSWTGFTGRTRPGGGGGGGGGFWTGMGTGGILGYLFGNQRRQPPMGFAGPTYNSNPSPAPKTSSGTRTASGFGTTKRR
The following text describes a protein:
Function:
Has bactericidal activity. Active against E.coli ML35 but not against S.aureus 502A. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (By similarity).
Subcellular Localization:
Secreted. Membrane. Note=Associates with tumor cell membrane-derived microvesicles.
Sequence:
DFASCHTNGGICLPNRCPGHMIQIGICFRPRVKCCRSW