lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the chaperone-assisted selective autophagy (CASA), a crucial process for protein quality control, particularly in mechanical strained cells and tissues such as muscle. Displays temperature-dependent chaperone activity.
Sequence:
MAEGDYYTLGNRQRIPRDPFREQSLASRFMDDDFGLPPFPNELSMDWPGWARPRLSHRLDAPWTGSLRSGFPRASMSSPQGFSSVYTESPRRASAPPTDSDEPWKVCVNVHSFKPEELNVKTKDGFVEVSGKHEEKQDEGGIVTKNFTKKIQIPLDVDPVTVFASLSPEGVLIIEARQTPPYYLYSNEMPAESMEEPEARPQEPSMTSTTTFEARE
The following text describes a protein:
Function:
May be required for ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGPEVRVFLPVAHAPSALPAERRGRGAAQRSMAGGGAGMGTDSGPGSGPGPGPAGQNVEPAAPERVLFPPTFSVSEIKNKQRRHFMFLRWKQQQRKEKLALKKKRRKEREALGDKAPPKAIPKTIENQRIYDETTVDPNDEEVAFDIATDEFAPYFNRQTVPKILITTSDRPRGRTVRFCEQLSTVIPNSHVYYRRGLALKRIIPQCIARDFTDLIVINEDRKIPNGLVLSHLPDGPTAHFRMSSVRLRKEIKRKGKEPTEHVPEVILNNFTTRLGHSIGRMFASLFPHDPQFIGRQVATFHNQRDYIFFRFHRYIFKSEKKVGIQELGPRFTLKLRSLQKGTFDSKFGEYEWIHKRREMDTSRRKFHL
The following text describes a protein:
Function:
Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
Sequence:
MIEKRNTIRMEQAREVLCNQITHLPVEKKHVTEALNQVLQEPIFAPFPAPYFRRSGYDGFAITEVDDGNYPITLRVVAEVPCGETYDKPLKPGETVRIMTGAKVPDNASKIIMLEQSREADNENEIILINTQKSSNITEIGTEFAKGDLLLDRGHILNAGSISLLSSFGIQEVQVIRKPKVAILSTGSELVPAGNPLPDGKIFNSNQPLLENLLKVHHAEICAAEQLPDNYEDTKNRLLELTKIADLIVTTGGVSVGDFDYMADIAKQEAELLFNKIQMRPGSPTTGMWLDKTLIIALSGNPGACFTGFYLLVEPVLTTLMGKDTTETTQVRAKMASDYTKNNGYDRFLRGTYRLSDEGEYLVELVGSDMSSALGNLHLTTCLFKIPRGQVGKLKGEEVEAWLLYSK
The following text describes a protein:
Function:
Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MKIKKYVVNDMNEAMTRIRYELGADAIIISQRKIRKGGFLGLFSKKSLEVTAAIDNYSTEKKYNSNTVNKINKGNNIEVIKRMLEERNNNVKYDNNINHDTNALDRYKEILESKSEGAQNKSLKGKKFSESKDLMDEIRDLKKIVKDIGKSEKSYADENSSLVKFFKDLDLEEEFIEEIIKKVGNLEENLEEREKIKRVIEDTIDVRVNSVGKVTVLVGPTGVGKTTTIAKLAGKLSLIDKKKVGLITIDTYRIGAVEQLKTYADIMNIPFKVVFSIKDMEKAIIDLDYCDVILVDTTGRSSKNMMQISELRAFIEKIKEKSVHLVISASTKNKDIETIVKGYSILEYENIIITKLDETSIYGSILTILDKGKNPISFITTGQDVPDDIKEGNKEEIAKIVLGENKLC
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MSKKHVSRKLKSAWRKHIDISDVDQFLEEQRQDERIGGRIADKPDQELFSEEKRPAKAKTTLRELRRNKFGELPRSLLPLVNTSNVSDPVVKRNVKKSRVTLAPVAPVASVRFRKRGRPSGIAKPTQEDLWAKETPVPGELQNEWIAKELVHHTLAHTGKPLVTNLPARMDPEQRRVPLRKRLPAEGLSYNPAIDDYLELKDKLVKEEKKIIRHEEHLDRVLTSKLGKMTPEERYRTAISEMSEGLLKPDKNNQSEEEEDEKKKDEEEEEKPVVVAKAKKRISKAKKRARMLQHKEEKLLEQELHKLVEIDRVEEIAAEVEQEVQQTQRKAEYRVRKRKAMRAKLDLPIDFVEPEKLSGSLRTIEPLNNLLATGLPKVRKVSILKRTRAEVERKMRRIPTKRYTRSSHKEPMLPPTKPAKRAK
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLSTKTSTSSTNNHEQDQLLKKSQKVSTTQRPNMKSRKGKHTGPVKSSGMKPKQIAVLNSTWNLRKWDKHVFEKQQLLFDGAVDVQTFEDSCKFLTPESYQDVVVERAADNQCGYPACDMKLKSTNTKSQFRISAVDRKVYDVTEIHSFCCSECFAASKYLATQLSSDPVYLRDVTKLPVLDLVPARKKLSEHFDQNTAKLNLDLTSSSKAAESSQENALGKSQHNAIHSYIDTLITSMPTLKLDESYLPIIEKPVALSSLDQSATAGFAFDGSISAMDTDVSTHSNSAFDLIEGYRAQSIPFSKSGSLARLSSSTAKSSWISSLPKMAGPSMVLDTVQNTSNTIVDSSQICSQVQPDDISMSENHIDSITTATVQQPDKHQPVKPPCVKKTLQYLRFSDPIEAPEFIKSTPTIPVVAFTESKDEILPLAMPKSILKQTMKPSIDPIIPLPNRDTPGQTNLKAPIETMVVENALVSNSKDVLDYCDAKESDDEDIHSKTSTDTADYGWFKPSTQKAKPLLSLFARIWMILDRIVTCKTLNLLVEYTKGTKHVERSSLVGLGNQEFLKRKEFFFEKMIKTWKLIRQRHGIDLNFEYELLCIVDTLNLNESMTALSAIEEWVLCSVFIRSVCDSLVESNQTPDNINWTEILEPAGMGNDELSALVRGTSMVKPQPSINNTVFVSQ
The following text describes a protein:
Function:
Positive regulator of brassinosteroid signaling.
Subcellular Localization:
Nucleus.
Sequence:
MGEFVDAERFECLKPSLPFMEMDTNLELMRQLAELNGSAMHSPSMGLMDYSEEYYLPHQSEFSIPYIDDLTGPPAERQKPIAESQPAGSVGEQSHGGRKRKMIAESNASSHNFSEVYSVIGSAEVNTEKKNGSESGRRRKSNSKEAGKPKEVVHVRARRGQATDSHSLAERVRRRKINERMRCLQDLVPGCYKTMGMAGMLDEIINYVQSLQNQVEFLSMKLSAASSFYDYSLGVEAVAITQVDGAYEGEEAERAQRKGHGDCTSVHSISMPSF
The following text describes a protein:
Function:
Component of the GTPBP3-MTO1 complex that catalyzes the 5-taurinomethyluridine (taum(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs (mt-tRNAs), which plays a role in mt-tRNA decoding and mitochondrial translation. Taum(5)U formation on mammalian mt-tRNA requires the presence of both GTPBP3-mediated GTPase activity and MTO1 catalytic activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MFYFRGCGRWVAVSFTKQQFPLARLSSDSAAPRTPHFDVIVIGGGHAGTEAATAAARCGSRTLLLTHRVDTIGQMSCNPSFGGIGKGHLMREVDALDGLCSRICDQSGVHYKVLNRRKGPAVWGLRAQIDRKLYKQNMQKEILNTPLLTVQEGAVEDLILTEPEPEHTGKCRVSGVVLVDGSTVYAESVILTTGTFLRGMIVIGLETHPAGRLGDQPSIGLAQTLEKLGFVVGRLKTGTPPRIAKESINFSILNKHIPDNPSIPFSFTNETVWIKPEDQLPCYLTHTNPRVDEIVLKNLHLNSHVKETTRGPRYCPSIESKVLRFPNRLHQVWLEPEGMDSDLIYPQGLSMTLPAELQEKMITCIRGLEKAKVIQPDGVLLLLPRMECNGAISAHHNLPLPGYGVQYDYLDPRQITPSLETHLVQRLFFAGQINGTTGYEEAAAQGVIAGINASLRVSRKPPFVVSRTEGYIGVLIDDLTTLGTSEPYRMFTSRVEFRLSLRPDNADSRLTLRGYKDAGCVSQQRYERACWMKSSLEEGISVLKSIEFLSSKWKKLIPEASISTSRSLPVRALDVLKYEEVDMDSLAKAVPEPLKKYTKCRELAERLKIEATYESVLFHQLQEIKGVQQDEALQLPKDLDYLTIRDVSLSHEVREKLHFSRPQTIGAASRIPGVTPAAIINLLRFVKTTQRRQSAMNESSKTDQYLCDADRLQEREL
The following text describes a protein:
Function:
Major regulator of extracellular matrix organization during tissue remodeling. Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves the ester bond between the C-terminus of the HC and GalNAc residue of the chondroitin sulfate chain in I-alpha-I complex followed by transesterification of the HC to hyaluronan. In the process, potentiates the antiprotease function of I-alpha-I complex through release of free bikunin. Acts as a catalyst in the formation of hyaluronan-HC oligomers and hyaluronan-rich matrix surrounding the cumulus cell-oocyte complex, a necessary step for oocyte fertilization. Assembles hyaluronan in pericellular matrices that serve as platforms for receptor clustering and signaling. Enables binding of hyaluronan deposited on the surface of macrophages to LYVE1 on lymphatic endothelium and facilitates macrophage extravasation. Alters hyaluronan binding to functionally latent CD44 on vascular endothelium, switching CD44 into an active state that supports leukocyte rolling. Modulates the interaction of chemokines with extracellular matrix components and proteoglycans on endothelial cell surface, likely preventing chemokine gradient formation. In a negative feedback mechanism, may limit excessive neutrophil recruitment at inflammatory sites by antagonizing the association of CXCL8 with glycosaminoglycans on vascular endothelium. Has a role in osteogenesis and bone remodeling. Inhibits BMP2-dependent differentiation of mesenchymal stem cell to osteoblasts. Protects against bone erosion during inflammation by inhibiting TNFSF11/RANKL-dependent osteoclast activation.
Subcellular Localization:
Secreted.
Domain:
The Link domain interacts with various extracellular matrix components, including heparin, heparan sulfates, hyaluronan and I-alpha-I complex. It is required for binding to various chemokines; The CUB domain is necessary for calcium ion binding and transesterification reaction. It is required for binding to FN1.
Sequence:
MIILIYLFLLLWEDTQGWGFKDGIFHNSIWLERAAGVYHREARSGKYKLTYAEAKAVCEFEGGHLATYKQLEAARKIGFHVCAAGWMAKGRVGYPIVKPGPNCGFGKTGIIDYGIRLNRSERWDAYCYNPHAKECGGVFTDPKQIFKSPGFPNEYEDNQICYWHIRLKYGQRIHLSFLDFDLEDDPGCLADYVEIYDSYDDVHGFVGRYCGDELPDDIISTGNVMTLKFLSDASVTAGGFQIKYVAMDPVSKSSQGKNTSTTSTGNKNFLAGRFSHL
The following text describes a protein:
Function:
Prenyltransferase that mediates the formation of menaquinone-4 (MK-4), a vitamin K2 isoform, thereby acting as a mitochondrial electron carrier. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. MK-4 acts as a membrane electron carrier downstream of a electron transport chain complex, improving mitochondrial oxygen consumption.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MATSSQLLPNGNLSRNGKTKTEDGEEVEAVVGARAAGADAGVALTGRLTGHPSTSGTFMKLKTYLLALRPWSLSASLVPTLLGSALAYRSQWAEEFSLATFFLTAFTVVTVHCAGNVVNTYFDFIKGIDKQKADDRTLVDHILTKDEVVSLGAILYMAGCGGFVLLAVLSPAKMEHLALIYFGGLSSSFLYTGGIGFKYIALGDLVILILFGPISVLFAFMSQTGHLDWTTMGYAIPLALNTEAILHSNNTRDADNDRRAGIVTLAILIGRTASHVLYAMLLFAPYSLFFIFGLKYSLWFLLPLVTLPQAFQIEKRFRNEQTMHLVPRQTAKLNFFFGILYVVACCCAHQLPTFGLRRN
The following text describes a protein:
Function:
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
Subcellular Localization:
Cytoplasm.
Sequence:
MSIAIIDYGSGNLHSAAKAFERAARSLEDPQKVFVTSDPDQAYGADRLVLPGVGAFADCRRGLDAVNGMVEAITEAVRVKARPMFGICVGMQLFATRGKEHVITQGLNWIGGDVEKITPRDESLKIPHMGWNTLDVLREHPVLNKLPLGPKGQHAYFVHSYHLNAANEADVLARADYGGPVTAIVAKDTAIGTQFHPEKSQRFGLALISNFLRWKP
The following text describes a protein:
Function:
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDAASLMGPSSADAPTDGEHRMGTTIVGVCYDGGVVLAADSRTSTGMYVANRASDKISQLTDNVYVCRSGSVADTQVISDYVRYFLHQHTIQLGQPATVKVASNLVRLLAYQNKSMLQAGMIVGGWDKYEGGQIYSVPLGGTILRQPFAIGGSGSSYLYGLMDHEWKEGMTQEEAEKFVVKVVSLAIARDGASGGVVRTVTINEAGVKRSFHPGDKLPLWHEEMEPQNSLLDILAAGSSDAMVQ
The following text describes a protein:
Function:
Glycosaminoglycan synthesis. The hyaluronic acid capsule is involved in the pathogenicity of group A Streptococci; it may be the major virulence determinant.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPIFKKTLIVLSFIFLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGKPHDYKVAAVIPSYNEDAESLLETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNREVDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSDTYIYPNALEELLKSFNDETVYAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPNLERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNKSFFRESIISVKKILSNPIVALWTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSIIFIVALCRNVHYMVKHPASFLLSPLYGILHLFVLQPLKLYSLCTIKNTEWGTRKKVTIFK
The following text describes a protein:
Function:
Prevents the establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of host interferon regulatory factor 7/IRF7, a transcription factor critical for the induction of interferons alpha and beta. Mechanistically, ORF45 competes with the associated IRF7 and inhibits its phosphorylation by IKBKE or TBK1 by acting as an alternative substrate. Acts as an activator of the NLRP1 inflammasome via interaction with the N-terminal part of host NLRP1: interaction promotes translocation of the N-terminal part of NLRP1 into the nucleus, relieving autoinhibition of the NLRP1 inflammasome and leading to its activation. Also plays a role in promoting the late transcription and translation of viral lytic genes by constitutively activating host extracellular signal-regulated kinase (ERK)-p90 ribosomal S6 kinase/RPS6KA1. In addition, supports the viral replication cycle by modulating host p53/TP53 signaling pathway. Interacts with host p53/TP53 and prevents its interaction with the deubiquitinase USP7, leading to sequestration of P53/TP53 in the host cytoplasm thereby diminishing its transcriptional activity.
Subcellular Localization:
Virion tegument. Host cytoplasm. Host nucleus. Host Golgi apparatus.
Sequence:
MAMFVRTSSSTHDEERMLPIEGAPRRRPPVKFIFPPPPLSSLPGFGRPRGYAGPTVIDMSAPDDVFAEDTPSPPATPLDLQISPDQSSGESEYDEDEEDEDEEENDDVQEEDEPEGYPADFFQPLSHLRPRPLARRAHTPKPVAVVAGRVRSSTDTAESEASMGWVSQDDGFSPAGLSPSDDEGVAILEPMAAYTGTGAYGLSPASRNSVPGTQSSPYSDPDEGPSWRPLRAAPTAIVDLTSDSDSDDSSNSPDVNNEAAFTDARHFSHQPPSSEEDGEDQGEVLSQRIGLMDVGQKRKRQSTASSGSEDVVRCQRQPNLSRKAVASVIIISSGSDTDEEPSSAVSVIVSPSSTKGHLPTQSPSTSAHSISSGSTTTAGSRCSDPTRILASTPPLCGNGAYNWPWLD
The following text describes a protein:
Function:
Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.
Subcellular Localization:
Cytoplasm.
Sequence:
MEEHRKLLPNATVEEYNYFEEDFVFQGLSWKKRQEFAEDTSFLSPFDKALQSKWEEKMNEGLFRYPLRNVQTKILPGSVSYVAQLNIQRSINRRKPEDIWSVQQKFNPNQFNYNKIKSEEIVFQMIRSEAEHSVDSHIVQGSMVNGMGSSECKSGSTPQGSCTLECKSSCTLVVINVSPLEFGHVLFMPDPSLCLPQILTENLMLFGMESVFLSSHPGFRVGFNSLGGFASVNHLHLHGFYLDHELLIESSCSKPLCPEINFHLVTHFPAPGFLFYTDGKDLKSTAQKICKVTDFLVAKNIAHNLFVTRGSNPDTGKVSEDRNGIRVIIWARKPSFGAKEVSAFNVALCELAGHLPVKNQEDFISITEDSVIAIIHSCLLADDEFTQLSLDLVQHLRKQ
The following text describes a protein:
Function:
May play a role in locomotion and behavior.
Subcellular Localization:
Cytoplasm.
Sequence:
MSNSTMEATQMKVKLAVDEMIDDLDKTYLRDMQKSMFQCSARCCDNKKTTRDAVENCVESCNDGMKKAQGYLEKELGGLQDQLSRCAMTCYDKLVQQFGPDVNKYSESQKLSFNEKLDSCVSVCADDHIKLIPAIKKRFAKNT
The following text describes a protein:
Function:
Component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. Regulates MAPK pathway and sporulation through H3K4 methylation.
Subcellular Localization:
Nucleus.
Sequence:
MLAHGSNDYGVSLKGNKTGSSPSKASSLNWNEPHTLNEQNTYCYCGKDRNLRFPDLQCSVCLNMFHLSCLSPPCTSMMGFSTNYQFVCKHCTEDGFERFERGVSAWKAITATAMANLVVKRYVETNPDVPVDSFNAEKMRNFQANTYFFKKKEDLIPFIEEHWQLLCPDREKVQTWQATLGSCLVANRDTYRAKDETMRNQNSEYALNNPNLFDFRSGYIFPFQRVGATVPKKRLVETETPPPSSSKLKEDYKDSKREMKRSNTPWSNASIKKNEVPTVPIRYKPPPWRDSDFETVPKLPIFYPNSSSPNFFSLSEIPFNRRGFRYSPCEAAKDLPNVMYREIELPPFTSRINWHDISTPVFIDHSALCATVEKGFRMARSNVFMTSGEWYFEIKIEKGGGDDGAHVRIGVSRREAPLDAPVGYDAYSYGLRDLGGQKVHMSRPRNFMDSFGTGDIIGLHISLPKPSFAQHTTLPSCHDRIPIRYKGQLYFEQPDYVPSKMMDELMIPSKHNRYIDLPYIPGSFIKVYKNGSYMGTAFENLLDFNPPNSINSNHYSFDDGSLGYYPSISMYGGGIARFQFGPQFSHRPLVLGSNVRPVSERYNEQIAEDVLCDILDEIDYAEDPNTSSVTIDVPQEPNAGITIIPEIKDITE
The following text describes a protein:
Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Essential for peroxisome biogenesis. Required for UBC4-independent ubiquitination of PEX5.
Sequence:
MSSTEKRLLKEYRAVKKELTEKRSPIHDTGIVDLHPLEDGLFRWSAVIRGPDQSPFEDALWKLEIDIPTNYPLDPPKIKFVVFGEEKIRQLQRKTSSGARKVCYKMPHPNVNFKTGEICLDILQQKWSPAWTLQSALVAIVVLLANPEPLSPLNIDMANLLKCDDTTAYKDLVHYYIAKYSAYESNDV
The following text describes a protein:
Function:
Plays a role in the arabinosylation of cell wall components. Involved in the arabinosylation of extensin proteins in root hair cells. Extensins are structural glycoproteins present in cell walls and its arabinosylation is important for cell elongation, root hair cell development, lateral root development and root hair tip growth.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Domain:
The conserved DXD motif is involved in enzyme activity.
Sequence:
MVEGWRNGFRDATNSKPLFVTIYATVIIGVLVSSFYVFSAIYSPTNGSSSFLSFPPLSTSGRIHSLPQENATLELPVAPPPPPQALPPPVLEEAQGNSLGKIWVSPPRDKKMPPLETFKLTKELFGERVKDNVIIVTFGNYAFMDFILTWVKHLTDLDLSNILVGAMDTKLLEALYWKGVPVFDMGSHMSTVDVGWGSPTFHKMGREKVILIDSVLPFGYELLMCDTDMVWLKNPMPYLARFPDADVLTSSDQVVPTVIDDSLDIWQQVGAAYNIGIFHWRPTESAKKLAKEWKEILLADDKVWDQNGFNEIVRRQLGPSVEGDSGLFYAYDGNLKVGILPASIFCSGHTYFVQAMYQQLRLEPYAVHTTFQYAGTEGKRHRLREGMVFYDPPEYYDSPGGFIAFKPSIPKSLLLDGKHTIESHFILVNHQMKQIRSALAIASLLNRTLVMPPIWCRLDRLWFGHPGTLQGSMTRQPFICPLDHVFEVNIMLKELPEEEFGPGIGIREYSFLDNPLLPKQVKESWLDVQLCQEGKEGCEASNNTSPSRVLKFPKRSNEDTFKAIFSSFDDVKVIKFSSIEDAFIGFSDKEREERFRRRVKRYVGIWCCEENKTPGHIYYDMYWDEKPGWKPVPPQTPEEDHPPL
The following text describes a protein:
Function:
May be involved in recombinational repair of damaged DNA.
Sequence:
MLTHLRIENFALIDNLALDFAGGLNVLTGETGAGKSIILDALDVVLGGRVSGAQVRTGAQRAVIEATFGPSAAIADWLAAQQIDSLEEGLVVVREISGKTNRARVNGVLVNQAVLRELREQLLEITAQGQSLQLEKPEVQLELLDNYGEIAPRRERFRQVYETLQRRKGELARKKAARDDRLQQLDLFRFQFEELSRAALDDPQEEEQLLADRSRLAHAVELQHNSLKLYEMLYEGALDQPAVTDLLGQSSELLIQMGEYDASLVPLGEMLENALVQVQECARAVNRYGETVESDPETLEYTEKRLRQLKNLRQKYGPTLADVIAHYRNLERDLAAIEGSGEDLEVEERELAGETRRATELAAELTRARTEAAGRLEGDLVRELAPLGMGKVRFAVRIEPSRLASSGADRVGFLWSPNPGEPLQPLTETASGGEMARFLLALKACLGGADRIATLVFDEIDVGVSGRVAQAVAEKLLQLGASHQVLCVTHQPLVAALADSHYRVHKAVLAEAGEERTVVRVETLNKTEARREELAQLVGGHSAHEALEFAGALLADADRRRSAVRP
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MRRATLGSMSPSQLNTRGATNGRAKGSRGSLIPRPPPAGASNVIKPSRPSMGRRSSMMGKGSGTQTETRPIGDRAFQQDCIRNLCNYLTTHGYVNAVSPKVLQAPSSKDVTSIIQFLFHQVDPNYKFMKIEEDVPIFFKRIGYPVQISRSALYAAGSPVSWPSLLAALTWLSQLLVAMESSSEGPDFSPFDDVRGNLLTDYINENYMNYLAGKDDEVDRLDEEFRKQFVQEKEKDAAECEQLQATLNKLKEEMQRAKNEMSPLVALETKKRDFQDDIVKFNQIITGFTAHKQALEKKVNEKRQELTTKKEEVLNTLKENEELKETVAAQQINAADVEKMLKEKEILDVNLQSLMSRKEELEKAAWNFEVQSSKKLRDLETKVNQFNDSCQRLKPTTGEDSHEAYQFEIKLQPRADTPDEILGGTLKTVLKPGFTELMDTCRKRLTEELEPETLKLQQQIFSREIAGRKKAEQIAAATAHIKKLEAQYNVRMDKLNAILAAKIAEREEYEMRTVTEEAEFRKLQVDVEQRLRELQVELDNTLRICQEEIEFEKNEGTEILEIILSTKERTQAMLKRVTDVSIQSTQVFHELLLSP
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil.
Sequence:
MDNKLIFVVKKINHNIDIKDYLREMENLSGRFIRKAVRDGRVFVNKEKVIKKHKLSQDDLIEIYMQEDEHQNIEPEDMNIEIVYEDNDIIVINKRPGIVVHPTKGHPTGTLSNGILYHFKKNGEKSIVRLVSRLDRDTSGLIIIAKNQFSHMRLASDMSKDRFRKIYIAVVHGSMKEKEGRINLPIYKEEESESIKRIVDERGQESITTYEVLEELSKGSVVRLELETGRTHQIRVHMSHLGHPLYGDSLYGKGEEEKEYIERQALHAYKLEFPHPRTGDVLKLQCSLPDDIKNLIEKIK
The following text describes a protein:
Function:
Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane.
Subcellular Localization:
Nucleus inner membrane; Single-pass membrane protein. Chromosome, telomere. Note=In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane.
Sequence:
MSLKPFTYPFPETRFLHAGTNVYKFKIRYGNSIRGEEIEDKGVIIQELEDSIRAVLANMDSLQPFVTEHFIVFPYKSKWERVSHLKFKHGEIILTPYPFVFTLYIEMKCFAESLPSGKPTDDIPLELVLTAKEAEEATMRKRKLMEEPSTPSRPGPHRAKMETWSEASSTKKALKEHKRSWGEDSQQDTPASDSTAVTEQDPMLGHSLPGLVVPPLEHSNPPPLKEPAARGFLGFLSALFPFRYFFRKSTQ
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MEDTVGDERPIKKEEDDRAEEQHSLVEETMSDQGETESLTESTEGGVPSTSALHVANTVKFKILSPMGGRTLEFAMVRGIANRDAQDELAMHLTNIFKLGLGIKEAFEKALNSEWQDLPWSDVDKVVPIVQRLNKCISSVVSLWRGATRPKTESEWFQNPYCTAEQCKKISFTVFNRVVKNAQVLNKCYKSFSSLTYGETSFDQIQIILDRLKMTEKDVFVDLGSGVGHVVTYAAAYSNAKRCVGIEINNVPADMATKMKKEFEGMMSWYGKKYRPFDLIHGDFLDDTFKKLLTEEATVIYINNFAFDPNLMFNIKQRILEMPSGTRIICTKSLSEEREDRGRGESDEAKKQRPISGRTLSRQTVDMMLDCDELPLADAPVSWSAGKGIQFLLFTVNHTKIEQIFQCAQNSSSGSGTSTRSGSAENVVAPIEDSHTDNSISATIDEVVSAKAPSTRGIRMYPEEDSDDNDDEDYPAPGSSRKNASKAEKRRGGGDGGVPKKRSSTGASSSRHGKKDSKKEAKSTPSSARRFAAATEVPMQRRDTKVKKEDPSSSTSQPHQSEDGRVVLDPSNPLDAHLSESNKRAPKRSIGGKDEKEKRRRGRPSKGGGAGDGSDKENGDDSDDNSSTTSSPSTSPTKKNPKKKKVEEKEKTPERPKTLTELYGPAANGHDEGFVKEEAPEWAGKEGKVSKKHGEWKAVFAPHYSIFEEDLTNLPPRRRSSLNPSLAPNLTQSESTKKKRKSVSKTAPTE
The following text describes a protein:
Function:
Regulates stability of MYCN in neuroblastoma cells by inhibiting GSK3B-mediated MYCN phosphorylation. Inhibits GSK3B activity by promoting its phosphorylation at 'Ser-9'.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQHPPCEPGNCLSLKEKKITEGSGGVCWGGETDASNPAPALTACCAAEREANVEQGLAGRLLLCNYERRVVRRCKIAGRGRAPLGTRPLDVSSFKLKEEGRPPCLKINK
The following text describes a protein:
Function:
Catalyzes the attachment of arginine to tRNA(Arg) in a two-step reaction: arginine is first activated by ATP to form Arg-AMP and then transferred to the acceptor end of tRNA(Arg).
Sequence:
MGSTGFSLSQLRQHGLINLLKKAQTGTAENIVIDYSSPNIAKRFHVGNLRSTLIGRYTAKLNSSIGHNVTSINYLGDWGRQMAIIIAYWPKVRPSDSYWNSVGDGEKVRLLTDCYVVGNRVIESDEQLRDDVRRIHLMMEHTKLTGEEADSDEIRQWRDIVKISANHLNHFYSLFDCQFTTWMYESEESGRAQLLVSDLLSKNLAVTDDKGTIMKDGDIFHRLGRSDGTTLYLTRDISSLLYRDKLYSADKYIYVVERAQRNHFTALKRVMELIGYEDLAAKIVHLSYGRVKGLSTRKGRTEVVEEILESGKELAKEWMGKSATAKELTQQESEETSLKLAISSLIVTEMRRARNSDYEFSWKRTFDPSSGNNALFLHSKYSRLCSIEETNRAMMDGLDEYPIIEEPSSIPLISSLISLYSSALSSSHSMESHELTNSLLSLGRECGKAGVTLRVKGSEENIARSRLALLNLAKRSIEESMGILGIPLISKM
The following text describes a protein:
Function:
Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity.
Subcellular Localization:
Cell surface. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
Sequence:
MSWQIPAVVMSFMALVAIWYYDSHYNSHMQAKVFPEITGYSSPTTGQATVKPSLLQPTNYVPHKTAAARSTDGHVTSQTVAKTSSSETLTTNTTIDVLATTSPVTTKSTLPTTPTTHTLVTTLATPNKSHVTFPVTEAKVGLSVGPSSPPVTVNPTAHTTGNRPSTASHTTGKTTQLSNQTTLPATLSTSPHNITTSQKPTQPTHTPGPTTATYNTTQTASPATIAPRPTLAPQPLSPKTGIYQVHNGSKLCIKAEMGIQLTVQDSVSVFSPQKYFNIDPNATQASGNCGSRKSNLLLNFQGGFVNLTFTKGEKSYYISEVEAYLTVSNPAKVYQGLKHAMMMFETVVGHSFKCVSEQSIQLSTYLQLKTMNVQLQAFDFEDDHFGNADECISDRNRREIPVAVGLSIAVLLAVLLTACLVTRKRPSRGYERM
The following text describes a protein:
Function:
Involved in the metabolism of isoprimeverose. Transports isoprimeverose into the cell. Transport is driven by the proton motive force generated by malolactic fermentation. Cannot transport D-xylose.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSVSMQHHSSEASPATQPASVIHKNMVPWSERFSYSLSDFACNLSFSLVSTYLMFFYTDVFGISAAIVGTLFLVARIVDAFDGPFWGIMIDHTHTRWGKSRPYWLWFAIPFAVFSVLCFTVPNMSTGMKVVWAYVTYIGVDVLYSAVNIPITSILPSLTSNPQERVTLSTIRQFMGTLGATIISTIALPLVAYFGGGSTSSAHGWFMVALIMAVIAMVIFFIVFANTKERVQTVQSKKSIPIKTSLKALKRNWPWVIVIFINFIYWLGMQTRSQVTVYFFKYNMHDATLASFILGLQLVALLAVVITPWTAKRIGKRNTMLMGMLLAIVGQLILWGGSKALNVPTITVGTIVGYLGTGFVSGLIAVMLADSVDYGEWKNGVRAEGIVTSFSSFSAKFGMGIGGAVTGLILSAGGYVANHAQSAQALNAIEMNYVWVPIVGFGLSAIALLFYKVDKIEPKMLADLEQKHAQENALADDQK