lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MGGKKKKSAAVSSSAQPAAAAAVTATNAASESTGKKQQQQRPNNEKTTSKENKPRAPKTYGLNANAQTDTNSGSDKSILKVIIQPELEKKVIKLINDYRQEYADKGPISGRLTSKKLLDLYTALQKFQFKTEHIEEAMKSSVLYGGDLHSALDWLCLNLRDDELPEGFSQKMQEEKQKTRPKFQPLQEDRKQQGNKNQEPKEEEKPKAKTPVKDDGGSMKEWILRYAQQSEDQSSDEEQKEDIVHNPELDEKFDPNDRYLLLTAQLYDAKEMTTTSKAKKDKMGQRAAQDRIRVIQQEMKTLESHPVFNTAIKVKDTPKEEKKAAVVTDGKEELNFNLFEQAEAAPAEKNAVAEKKKKEPKDIRNFDYTSRSWTGKSPKQFLIDWCRKNLPKSPPPSFNKVAAGRYWKCKVRIQRPTDVLEVCPTILTEDGMQAQHLGATLALYNLVKGQSVHQLLPPTYRDVWLEWRDGEQKEEEQTLLAINKPRDQFISRLLTRLKQQQSLQSQPEPQKLLQDAEPEDSWENLDTQEEQEPQCGAASGGPAGLVVEEASRRLLLKLQASPLARRLLDERKQLPVFQHREQVLEALRHHRVLVIAGETGSGKSTQIPQFILEELLAAGDTAQPCSVVVTQPRRISAMSLACRVSQELGSEDGPGSMNSLCGYQIRMENRSSEATRLLYCTTGVLLRKLQQDRHLNSLTHIIVDEVHERSVQSDFLLTILKEVVHKRADLRLILMSATVDCQKFANYFNRCPVVSIPGRTFPVEVFHLEDIVEETGYVLEQDSEYSQKFVEEEEEVNIGITQKGGKTVQHQELIVRDSASGWDLGPELDHFSSRTRHILQYMNPNKINMDLILDLLAYLDKSPQFNAVDGAVLVFLPGLAHIQQLHDLLSTDKRFSSKDRYKLVALHSSLSSQDQSSAFTVPPAGVRKIVLSTNIAETGVTIPDVVFVIDTGRTKENRYHESSQMSSLVEMFVSKASALQRQGRAGRVREGFCFRLYPKFRFESFIDYSIPEILRVPLEELCLHIMKCEYGSPEDFLSRSLDAPQQQAVCNAVSLLRRIGACQQDTHTLTPLGHHLAALPVNVKIGKMLIFGAIFGCLEPIATIAAAMSEKSPFATPMSRKEEANLAKSALAVANSDHMTIYKAYLGWRSSRTEGTRAEMNYCRRHFLNRTALITIEEVKQELMRMVEQAGFVSSKLGRTPRPRPSTETKAPLSISTQDVCVVKATLTAGLYDNVGRILYSPSLDVQERVVCVVETAQGKAHVHPSSVNRFLQTHGWMLFQEKVKYSKVFLKDTTLISPLSMLLFGGDIDVQHRERLISLDGWICFQAPVRIGVIFKHLRKLIDSLLERKLANPKMNLEDEKTIQIIIELIKSENMI
The following text describes a protein:
Function:
Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Sequence:
MDPLTRPGGDIMRRNPQQDYELVQRVGSGTYGDVYKARNVHSGEMAAVKIIKLEPGDDFSLIQQEIYMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHMKGKMHRDIKGANILLTDHGDIKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFELHPMRALFLMSKSNFQPPKLKEKTKWSSTFHNFVKVALTKNPKKRPTAERLLTHSFVGQPGLSRSLAVELLDKVNNPDNHPHYSETDDDDFEPHPIIRHTIRSTNRNVRAERTASEINFDKLQFEPPLRKETEARDEMVVAGGAHFASHWSPFVDGSSCAKGPLTKFGDAHEDAEESTLKRAGPPPLPPKPRLSIYQEEGLVDDEKIQTIKYCPDSQGQVPPAHRRQSIPVCGPQTEPTPIGMTTSVSSPGLLTVRYSDMGNGDSGPKHLEENADGLGHMPQLPRKKEKREFPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQLFPRRCTWLYVINNTLMSLSAGKTFQLYSHNLIALFEQAKKTGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQLGIVLLQWYEPMQKFMLIKHFDFPLPTPLHVFEMLVIPEQEYPMVCVAISKGIEPNQVVQFETINLNSASSWFTEIGAGCQQLDAIHVTQLERDTVLVCLDRFVKIVNLHGKLKSSKKLASELSFDFCIESVVCLQDSVLAFWKHGMQGKSFKSNEVTQEISDETRVFRLLGSDRVVVLESRPTDNPTAHSNLYILAGHENSY
The following text describes a protein:
Function:
Intake of glucose and galactose.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTLDKSQQKSSFLPMAIVAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGVMMIAGLLFIPAAKTQVFALFLFAQLVMGAGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSALILDSFKDRIGTTLTQVQIDEMANGLVLPYLGMAVFIGILALAVKKSPLPELSNEDEVADHTDKSQIKAALSHPNLALGVLALFVYVAVEVIAGDTIGTFALSLGIDHYGVMTSYTMVCMVLGYILGILLIPRVISQPTALMISAILGLLLTLGILFGDNNSYAIANLLLVPFGGVALPDTLLLIAFLGLANAIVWPAVWPLALSGMGKLTSTGSALLIMGIAGGAFGPVSWGLMSSATDMGQQGGYMVMLPCYLFILFYAVKGHKMRSWSAK
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear.
Sequence:
MPLKIPPAKANLTARTTAAADSLTEWIHKNPDLLNACNGLRPEIIGKPRDLNSQKKQKKSVTKTVQQALNPTIIPSSPVIQGDNPDEPQSSHPSAGHTPGPQTPLNSPKNPPPSPS
The following text describes a protein:
Function:
May be involved in cell wall organization and biogenesis.
Miscellaneous:
MISCELLANEOUS: Present with 846 molecules/cell in log phase SD medium.
Sequence:
MQSSLPLCREFFEKITAYLDYHDFRLTITANQPSITLPYYVDEKAHSIELIIFKTTFLSLFQEAHTYFNKTFSDQSGISNENIYYMTVGFLLTTPENKTVYNVHEDLLKRYFQDNSVLVIPDLLVKEVRLIQRLLCSSNNRINKSSSLWILYRKLFVLSLDANTLVLPDILFVFHSSGSQHFSNYYCWNTARWFYDNLPYNKRIELFNLTKRFCFQNVKDCSSWSALAYMVCQQEEKKTDNIRDFQRLTSSFNVPFKINKVDLNFQVQPADAFTQELVKWIDRTYAADWPPYLCLLQITKFNITLRIEMDSVLLTWRNEILNFEENSGHIKMINNTPIVPEKFSNDLLTSVNFAHFGYKKLFLNKFLDKNKKEQSDS
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (By similarity). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin (By similarity).
Subcellular Localization:
Peroxisome membrane; Single-pass membrane protein.
Sequence:
MASSEQAEQPNQPSSPPGSENVVPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDLAFQQSGTAADEPSPLGPATPVVPVQPPHLTPQPYSPRGSRWRDYGALAIIMAGIAFGFHQLYKRYLLPLILGGREDRKQLERMAASLSELSGTVAQTVTQVQTTLASVQELLRQQQQKVQELAHELATAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSSSPSSPAAVNHHSSSDISPVSNESTSSSPGKDSHSPEGSTATYHLLGPQEEGEGVLDVKGQVRMEVQGEEEKREDKEDEDDEDDDVSHVDEEDVLGVQREDRRGGDGQINEQVEKLRRPEGASNETERD
The following text describes a protein:
Function:
Transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. Plays a costimulatory role in T-cell activation upon binding to its ligand K12/SECTM1. In turn, mediates the production of cytokines such as IL-2. On resting NK-cells, CD7 activation results in a significant induction of interferon-gamma levels.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAGPPRLLLLPLLLALARGLPGALAAQEVQQSPHCTTVPVGASVNITCSTSGGLRGIYLRQLGPQPQDIIYYEDGVVPTTDRRFRGRIDFSGSQDNLTITMHRLQLSDTGTYTCQAITEVNVYGSGTLVLVTEEQSQGWHRCSDAPPRASALPAPPTGSALPDPQTASALPDPPAASALPAALAVISFLLGLGLGVACVLARTQIKKLCSWRDKNSAACVVYEDMSHSRCNTLSSPNQYQ
The following text describes a protein:
Function:
Mediates thiamine transport.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKKHSARVAPLSACNSPVLTLTKVEGEERPRDSPGPAEAQAPAGVEAGGRASRRCWTCSRAQLKKIFWGVAVVLCVCSSWAGSTQLAKLTFRKFDAPFTLTWFATNWNFLFFPLYYVGHVCKSTEKQSVKQRYRECCRFFGDNGLTLKVFFTKAAPFGVLWTLTNYLYLHAIKKINTTDVSVLFCCNKAFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYADGFHSHSVIGIALVVASASMSALYKVLFKLLLGSAKFGEAALFLSILGVFNILFITCIPIILYFTKVEYWSSFDDIPWGNLCGFSVLLLTFNIVLNFGIAVTYPTLMSLGIVLSIPVNAVIDHYTSQIVFNGVRVIAIIIIGLGFLLLLLPEEWDVWLIKLLTRLKVRKKEEPAEGAADLSSGPQSKNRRARPSFAR
The following text describes a protein:
Function:
Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Also has a role in G2/M regulation.
Subcellular Localization:
Cytoplasm.
Sequence:
MRPPDDQINNNVGSNSHLEKLKEAMDHQLQKSSKIVGSFTNSQNSSVGSVHSPILESPTSLNRQHRNSFSFNNVSSPSLEDERLINFPRVNPNRLMTSKRPNELFKTSSMSSDCYSPQKSRESLNSLCHSPAPSVSSCGNALNNDNTSASHSLTDEQPFETDSSANLFKQLQEKRNRTIGNVYEMACLLVFKTGLMNFWKNIIDFFAQQFFSTQISVVEPRDLSDIYNTPWQLRCYYDGGSHYDPYSNPISVNDNLASSSYVTVVASDGSKGIIYKDPASLKHEGDLLIDSKVVQTVLERATLLVYTRKQQHIVKNTKVHDNDYFSSIPNVDDIRSIKNSWKVFHDEKLNELKKQVEISASAAQLNGLYPQKKRAFVSHFSQNRKPYSQSDISKAQSSSFSEEPSNIYDEYEQNLLSPWSRSPVASPSIQTDPNRNPFFQNCLQESSFATESSTEKSASESVSETAVNDDCKGMNFSGNRRQEDHLNDFTSFPTETAVSIVHVPLMFPCSDQTSSRGRAPIAILSFKSNLVPYPENLIASIERLIPFIFSSYSNSQSVPLLPCPTQRHLLFNTSSTDNTKELSMSASSENSDCPHKEGECVGSFCNINAKGSSLNNIPKLPRFVPVPSEFFKKNQRSWVTLKKHRLLARLKSRISKKNSKVNENLRFSLNDGENYSNETITLKKDEIVLDKSKSYACCTSESHKYVQGHCGGQAPPFPLLKVIIDSIPVHVFTADPGSGKLTWVNRKTLLYCGLNMNEQIELQFSRIHPDDLPNFLNDWKSSLFSGSGFYHEIRLQRFDNVYRYFICRAVPLRDCTGSVLHFFGTMTDVHDQKLAERELQKQSAIAANENSYRSLAEASPQIVFAANGKNGIIYANAQWLSYSGLSLESSLGLGFLSAVYHADRKKCLLPESLEGTFNNQDESNGTKTFAAEIRFRSTDGHYRWHLVKSVCVNNSADTSTNLWLGTCTDIHDHKMLEEKLQESNIEAQRIVRSKMQYLSNMSHEIRTPLIGITGMVSFLLETQMSAEQLSYARIIQQSAKSLLTVINDILDLSKVRAGMMKLTSQRFSVRAMMEDANETLGTLAFSKGIELNYTVDIDVPDIVFGDNMRMRQVALNVIGNAIKFTNVGEVFTRCSVEKIDYSTNTVVLKWECIDTGQGFNRDDQLQMFKPFSQVESSTLPRHGGSGLGLVISKELVELHNGSMSCQSRRGVGTRFMWTATFTMDKTPLKFEPPDGCCPVCFCPYEKSKQSTEDYYCADDGNDKSATNFVKLAVNKADPGRESNRRKLESDKNVQSNKYVNPFASESEFCRCGASADPYTVLFWRLYRNKPSGIKLDKSALAVVVSHTKYSSEAIGNMLQSIIDISSFKDIVRYGNTYEAFEELLENPMQSKVTHIILNLPDIEAYVLFVKSLQLCSLYKDTKFILVTSTRQKESLSKIFSDSEDCNSESIHYVLKLVKPSKFFPLFYSDSEEKGKIGALNDMTRKAAMEQKADAETLRYNLAKSGFSVLLAEDNIINIKVISRYLERIGVKFKVTMDGLQCVEEWKREKPNFYSLILMDLQMPVMDGYQACNEIRKYELENDYPKVPIVALSANALPHVVLSCKDSGFDSYLAKPITLQHLSLIISGILNYTNQSKLHK
The following text describes a protein:
Function:
Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRRTLSPVPRPGTSLGGGGESTSVAVAIGSPLSKCNHDPSSSFASTQYGFFVLNLFPKTSSRSLEKQKPKGNAWRRPFFHFFLCFLVGVFLGFTPIVSLTTSTYVHSRSQAFSFQQLGKVQLYDVVNHVMSANMLKNDSVKQESQTLETGFGKFLIIVTTTPTRGYYLHRLAHTLKTVEPPLLWVVVEMTRQSRETSEILRKSGVMYRHLVCTKNATEVKDPRVHQRNVALSHIETHRLDGIVYFADDTNIYSTQLFQHLRQIRRFGTWQVAKLKKSTRVAATFVGPICNGTQVIGWHTTNVMRRYHAELSGFAFNSTILWDPKQWHRPSTQRIRHLDTVKDLFQASAFIEQVVEGETEMEGIPEECSEVLVWYVPMEIDQLSSSNATILDPLSISM
The following text describes a protein:
Function:
Switches off the PcM promoter thereby blocking expression of the major repressor Repc (latency factor) and favoring transcription from the early promoter (Pe) and hence viral transposition and lytic development. Negatively regulates the early promoter (Pe) thereby controlling its own expression and keeping the level of early genes expression independent of the viral genome copy number.
Subcellular Localization:
Host cytoplasm.
Sequence:
MCSNEKARDWHRADVIAGLKKRKLSLSALSRQFGYAPTTLANALERHWPKGEQIIANALETKPEVIWPSRYQAGE
The following text describes a protein:
Function:
Required for stereotypic branching pattern of PVD somatosensory neurons. Induces and maintains tertiary branches in dendrites. Acts through the neuronal transmembrane receptor dma-1 with cell adhesion molecule sax-7 and lect-2.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Secreted.
Sequence:
MMISILLVFAVSTAYCRDYGREMRATRMSVVDFWKNETKGDGLNVRVAHGVNSWPDLVDQLHEPFLNKSMMIEGDVFMQAHRRPRHRAVPVMKADTKLADRITFKEWLREVATMNKAIKINFRSNEVVRPVLQDLYASQADPTSPVLQYPVILHANVFRSPRSVETEVDPSTFVEKAKDLFPDATLSLGWTKQSNFSHLHPKFKKLSWRQLFHILEYISRLDQPVMLSVRLSVAAHSKEQLLWLLGMDQSISLLLWSDAEDHVTNWTPIVELRRSTTKNRILYDLDPKHRKFLQTDSNEPIATPPTFSLQDWQAVEFSSSGSQLSTVVRSEKGPAFLGEPTALLLSKIPPPNFPSEQKISGKVHFLPKKGMENVDLDENSGVSIYLMDKVQDIDSPKIKNSLEVFIGFDGKIKITNGQLKNLPYYETKSVGQLPDSDCYGFEVTDMGWRVKLDAWTAECGNQKLRKRRTVSIELDTPFQKNRHLRNVVVSKKGDSAVDFLLEELQHKNAYNYRNPWITVVSTILLMIYLL
The following text describes a protein:
Function:
DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
Subcellular Localization:
Nucleus.
Sequence:
MFVGSRVYVVPTGMGKPRVQLFLKKLVEHGAEIADSEKDATHVVVAECVDRERLPKLIDSKKLSPSTRIVRSAWISDSLKNASLASTMPYALTCDLPHECGETVLNSDCAGPSGAEVGAADHGKEPEEPARKECADVPVNRNVHIIEQLQAMVETYQSTKDHWRALSYERAIMALKRHPTEITSWEEARSLPKVGERLADKIWEIVERGKLRKLEEFQGQERLTALQLFTKIWGSGPSTAERWVHQGFTTLEELASSGQLTGQQKIGLKHFHDFLEKMPREEAGEIADTVAKAALSLQPGLTVVPCGSYRRGKSMCGDVDVLISHAELSALDGLLNRLLQLLRSSGFLTDGLAVPHGTGVPSKYMGVCRIDRPGSKHRRLDVFVIPPDELACALLAYTGSAHFNRSLRLRARRMGMALSDRGLRQGVWRKVGIGSHTGFPRGAEKRSLGSLVSTPTEASILEHLGLSYRPPEQREQL
The following text describes a protein:
Function:
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAKDDILRSIKNSKLANAFIKVNREDFLPQLLKKYAYDPNYVDKPFYITPNVTTTALSLGMYMLDILNLGETQKVLEIGTGIGYYTALMAEVVGDNNVISLEIDDTIFEYAKNILLPKYPRIKLIKTDGSLGYDKEAPYDRIIIWAAAPTVPCKLYDQLRENGIMVVPIGSEKAQGLYRITKIGYEPKIERLGDVIFMKMRGLFGFYEDDDPNERRIKKIEEKVNRLLSKFMSQS
The following text describes a protein:
Function:
Voltage-dependent high-conductance channel with a slight cation-selectivity; selective for amino acids but excludes triosephosphates or uncharged sugars (By similarity). Non-essential amino acid-selective channel protein and translocation pore for NADPH:protochlorophyllide oxidoreductase A (PORA) and possibly PORB. Involved in PORA precursor (pPORA) import and thus confers photoprotection onto etiolated seedlings during greening.
Subcellular Localization:
Plastid, chloroplast outer membrane; Multi-pass membrane protein. Plastid, etioplast membrane; Multi-pass membrane protein.
Sequence:
MPSSTFSGTVSTPKLSVAVDMGNPFLNLTVDAFLKIGAVGVTKSLAEDTYKAIDKGSLSKSTLEHALKKLCKEGVYWGAAGGVYIGTEYGIERIRGSRDWKNAMLAGAATGAVLSAVGKKGKDTIVIDAILGGALATASQFVNNHYFY
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYIFVVLGLLTCGLISTTITNNFYLGDIYMKIVVAYLTELNLYIFSLYVLVVVNLRQRKRWYLLMRHLEIIKIKIKVPKKKGWKLPYFSKFWGFCFLTLLCEALVDFRWAFLFGWRYLNKFNVRLVQIFFTNYYKFMLCVVLNTFRVCYQKIRHQKTLNETVQIFVQLRQTIDVFNEIFQFPIALMVAFTTFEVLNYILFTLYVKIEVSVFESIVLASLRLGPTVVWTTVLLLLCDYVRQEGEKIVTLFYEMRLQNYELFELTEYVEENLPVLTAGYFRLGKPTILRMFATVANFVIVVVQVTNKN
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MATPTSRPSSIAIDDANDRPLEAPSSPVAAMEDLSLSPTPRNDDEDDEDYDLASASKLIPLSMTDSASGERPLPSLHSPLMYRDVPFAGLFVLHLILMLVATSSIRAVGEQEEQADERSDVVGGLQQDASLAQDDADVGVALRSLCVVNMLFALGWLLLFIFYSKLRFVQGSCIFSMAGLSMLAAMLFLLESGEGMFWGVICSGVVVLDLVWYARANHGLDFVAVFFELVVEFLVAHPALGGATCVMLVAYTIWASWICTTIGYVGRDLSPWNFSIIYLVFHFYWMSNVFKNILTIVASGTTMIWYYRNESTEISPDIRENISDHDSPSDEANGQVQQNPSTDYLDRKVVLHYARCAMSSSFGSICIGSLLCPLAHLVWNALRWARRDESVLSRRFMSLRSERVEYFIRTYHKYSFVHVAGYNKPYYVAAQDAWKLIEHHGVEAIVDDDLTSRILLLGGNGWAGIMSALTASALAGASSHATFFTLAAFTLCYTTISLATQVIAAVIKTLFVCFAENPGRLSQLHPLIYHRFVRLAELKSFRDHKAPASTRA
The following text describes a protein:
Function:
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). May also participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor. May also play a role in intracellular vesicle trafficking.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Lysosome membrane.
Sequence:
MSETTPNNTSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNHNNNNNTNNNNIDTFSQKASNDIVKPILPVTEDLQNSTKEMFTKVSSYIKSELATTVSDYNLLIQMNNITSSKYQDMTNVTKGLSVFMGDLKIKYEEFQPYFDKINELDKNVTDLEKTVQLLDEYTKRLEQKVKNIDKSSLLPTKQIQPPQPIPQQQPAQPAQPTQPTQPAQQPSQVSTETKPQENIENK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MSDIDEESSKLFSQDSMQQDDDDEHQRLDNDDIWKVLQMFFQTHGLVSQQIGSYESFVENVIKFVRGHEGTFVVRVKPQYKEEERQEAYLEYLYQFQITRCFMGKKNIHVDKFEEEIFPMIARLRDLTYSRQLKIDLEVTMQQRNKRDGTIEEKSKQQFKGLPFFKLPIMVRSRFCSLQKDPKDAELIQLRIQNGECGFDQGGYFILRGSEKVIVAQERIANNVVLVFKSKIVNKPWVAEIRSQPDLFSNPNVFKVELRYIQNTPVIRCSVKQFNSTQGIPLFTLFRALGISSDQEILERIVYNLEDEFMGPMLEMLYGSLQEGGEYEDEELCLRWIGNKIKKAENQDPETLIQEAKKLINKNILPHIGVSTESRDRKAYFLGYIVHRLLNASLGKTDQDDRDHYGKKRLDMAGAMMMGVFKTSFEQFKQNSKKALEKYINGGRRGRGQQTKIENMRQPDDIKSFFDGEQISKDIDNALATGNWGRSKEGQVVKTGVAQTLKRETSLFATLSHLRRMNAPINPQMKLSKPRQLHNTHFGFICPAETPEGQKIGIVKNLSLMTTVSNDLQSKDKETLLKLIMVSQQNDFDFILLQGDFQAQDIPRMTKVLVDGNWIGFTRNPEQFIHEFKNLRSAEESYIPIEVSINFDYVNKEIRIYTDAGRCMRPLFIVQNNKLKLMKGVLNQINDWEELLKNKCVELLDVEEEEGSLIAMDIDIMMRGTQNFKRYTHCEIHPCMMFGVCASVIPFANHNQGPRNTLQSAMGKQAMGLNSTNFNIRFDTLVHILHYPQKPLASSRAVDFITVNEVPIGINCVTSIACFTGYNQEDSIIINQYAIDRGFFRSVFYRTYKESEDKDPDNFTETKITKPIGDNFAGKLFIKLDSDGIVPPGTKVDEEEPIIGKELIIDNIMLNTANGQKNTKECSLLTRRAERGVVDSVLISENQKGYKLVKVKVRSLRIPQIGDKFCSRHGQKGTCGMTYRQEDLPYTLVGISPDLTINPHCIPSRMTIGHLIECLSSKLASIKGQFNDATPFAQILVNDIANELHKVGWQKWGNEVMTNPYTGNMFSIPIFVGPTYYQRLRHLVDDKMYARSRGPVTGITRQPTHGRSRKGGLRFGEMERDCIISHGTAKFLKERTYDVSDAFRVHVCSKCGMFAVANLENQEFYCNLCKNQNNQNKIYQVQMPYAAKTLIQELISMNIAPRLKFDQSKMKHEI
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
FLVLLNFAIIASADKNDWFSTTAGMQNLIDVENNFLSTLEGYIEGMQMSLDKIKTFKDIMRKDVIPAVSDPEVYIGHPINQYALIKRFALKWSRVGELLDGYSRKGKETRAQYHDAIKMLPNEDDMIGAAEAIARLQSYYSLNMDDLTNGNVKDVTSPSLLNSKDCFRIGKSAYTNRRFDLCEIWMNKSLELYVEQKGITRENIWSYLKHKISFKTYQGVNQTMHINAFLEDDTNNQESSTAGYDIILIYINSEVLLVLFINRIAHTQNYEYKKINSTLPKNITLHLLQNSLTLPQAHFVFQQYTHFVQCQAAWSKKSVNVFVNILIQVLLFYQLLRANGASSDGFGKIKYRISNTAWLDDKDSSSVKRLSQRLADVTGLTGSSELLQVANYGMAGHYIAHFDAMTPDDRNENYEYGNTGQRIATALVYLSEVQKGGSTAFFYPNIVAEPIKGSAVFWYNLYPSGALDKRTLHAACPVLIGNKWACNKWFRELGHEFVRKCGLFQNAENRMF
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
Sequence:
MEALLAVEETGNDLWKELKELYWAQYVQNSVDKVQFERYVRKVKSADDYWLVRALLAFSDSRKACTFNSRFEWLTMQAHGRQYPPLASKDAGKLIWNARREFRYAEPQQAAYKQLARPRGDAVADIQQHPDLGNCSMVCALINVKRTCGTADMVADCGDVAQVNLFFNGARRLVTLHRAEVRQNMRREQLAVLSPDMHDKLIEQAYFEVAHGMNYESMGSNTAMDTYMLCGWFPLVVETSEVDFPFVQRYLARGAMLALGTHATRTIDSFCLRKNHDYAVLDVCGTVFRIRDPLVAGNVIELAWEDVRTAFHLLYINWDAHTQCQLYEKFHFRYNSAVHNRFMSWLNKPTYRVVNDTESELPVYALFERHLSNRKYDNSIVGVISGENLVSDTEEGNNIGMQWVELTVPPHSSRILFYHSNTNTNCTLHLFSNSPRLKVAKWSSAESSRLAVLDGCWQPISKNLTFTHWPAFKFEIKHPETDGVHVSLQFCWANEHSAALFIYHASDYRYEKPLLHRPGPLPFPQAFFELALDTNTPYVVLCQSMDVGADAAFQLAIQTEKQGSVISTVPTSRAYGGLRFHTSKLVSTAAKRIELPFKVSRSTDLHITLYSKSSPLVLKCAVFSDGSDEAITATPGFVPINDYPYVLPITFAKERSLVLLIELQDTVPDSTVTIEIGSNCAFNFCGHDVDLARV
The following text describes a protein:
Function:
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Chromosome. Note=Localizes with RNA polymerase II at many transcriptionally active sites along polytene euchromatic chromosome arms and at developmental puff sites. Upon heat shock, relocalizes together with RNA polymerase II to selected heat shock puffs. Associates to transcriptionally active chromatin at snRNA genes.
Sequence:
MTNSIASTKCLPNALSTGNYGMSQSHRYTDDSKEYIIVKLTDSAFRAIEEYQRDDNAKRLQPGQRAKIQFVGNTGVIQFPRPATDANGIPNANGNGSDATGAGGGGGRKFGFTINNMEGTLECVQQQQRSLGVLGAVTLRMRIHANEDVYDSTRTKMAIAEETEKSKCIREIKPNQSDIGRKVKKPPSAIQSSASTASAFSSNSSNSGLTTTAFHHHSNSNNSGNNNNRSSSSSNSFNSNNHSRKLGSSPFNGLGVGSSSSSSAFASRSPNPSTLGAIGTVNGSGVVGGRYGGGAASSLASTFANGISQGYHNLSGSSPRDSMTAGTSSATASSVISSRNKMPSGGLTSSNSNSSSSSRSANSKSSGGNKMSDVSRRNIRERLIHLLALKAFKKPELFARLKNEGIRDRERNQITNILMDISTMSHNTYNLRRQMWNDVDENWPFFSEQEVQQLKRRKPQNLTPPMSSDAGSSTSGQSPTSTHTGSPPPPSSNGGPGGVGSGAGGTSMKRTSLEYDETMFSTVQPKKQRISHYKKDTPPSGTSYSSAGVSMSLGSSGSSSRSRYTPPQRQPGPLDDHSTTDLSYNVLDNIVEFMSSTAAATQQSMEQQQHPRSNSSNNRRGSSSLAGTSNGGNNKDKRNSTGSNSSSSSGYETQQDRQRSTTPMSSNRSSASSSTTPPKLAASFVPAATSGSASGTSKQRMPPQQSDYNSYNSNNAQHVASNSKKRMGSVGPSGGSNGQRQRSASGSNSGYQQVPPPSSNSRSSIQQQNQHQKQQVQQKQAPSQQQQQQQQQYHQQAKHPSPSQQLAAAAHAYAHATADTDSSATPRYDFSQYVPIQTLEVRRRYKTEFESDYDEYRKLLTRVEDVRNRFQDLSERLESARRCDNGYGDYDHIKRQIVCEYERINNDRTIGEDKERFDYLHAKLAHIKQLVMDYDKTLMSATMAMAPTDVVAAQGPDPAVAKAAARLAEHHRRQHHAAETIKQQQQQKQTHQHHLQRHLQHHLQQQQNLLQQQQNLLQQQSVSNSDDSSDSSDSNDDDDDDDEDCDDSNSNTDDDEARY
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MGHWPLSPRKSRKAPGKSLRSTVSRQFIWCAAHLELVYLVTALVPSDTACLASSPGSSRRTAVWISREIMSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRGAEQAAGRRDHRAGRRAAQHPGGAAAQEDREAGQEQVKGALSTPPTPDSGSENNPPPSPSQRLFSEPPTFI
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MQYQAFFQMFHLLNSINSVMHTGKFQLMMTTFFLSSRSNQLNQPSSRSLMKKLRSVMKMLVIVKMSEAVEEEVDKNIKDNEKMIIANESIEVLRDIQNDETYIVINPKYTDPVSGEVIIEVCREGTMKNSDDAQQDKTEKLKGSYKLYKCPSCNLHSYNTEDLLIHNVKEHIKKHDVSSDINNTSTTNNSSTVNAVEQYSCRSCMLSFVTAGDLKTHNKVHVGERPFKCSVCGRSFKDNNYFRLHSKIHSKDRTYPCRICNEPIQWDQLKDHRETHMNERPFECTVCKKSFKLRQQLRAHIKLHARENRSVCEYCCKLFASVEELNSHVASHVKDRPFKCSICLKLLKSKFSLEYHMKWHQERKHLVCAVCHKSFTHRHKLKSHVQIHQEKRIKPFSCKICNASFVSKGNLSKHEEIHNDILHTCTLCNKSFQKKSNLASHMKTHSDQQPEKRHTCDRCGKSFGTSHILKVHMRIHTGERPYTCKICAARFAQKSTLRFHNKSHDLLLFKCDTCDLHFKKVSSLEKHRVKHTMTKCKICERSFLSKKSISKHMKLHTGLWIFKCTFCDKSFEVKKWLHEHLKVHTSKKQRLHNNNNNDDNNNDNNNNNDNNNNDDDDDDDDNNNNNNNNNDNNNDNINDDNDNNNNNNNNNNNNNNNNNNGNNNDTFAVISMGVILYDDAISNVDDAVFNVGDVTGDVTSRVDDVISNFQGSSVCLVCALRYIPLYVVFRF
The following text describes a protein:
Function:
Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
Sequence:
MTTSEPYERAFDEDIQRGTTEPCPECGGPVRTNSAETVCADCGLIIDEQSIDRGPEWHRDDADTAKRTGAPLTPARHDRGLSTVIGSGQDARGTALSSEKRRRLARMRREQSRGRWRSTKERNLGHGLTEIRRIASALGLADSVRDQACQLFRTAQNERLLKGRSIEAMAAASVFGACRCNGESWLIDDVAPMAQVGQNRVENAYTVLNEELGLPTPPVSLDQFVPRLASDLGCTDVVRRRAEELVVQAVDAGITTGVHPSGFAAACLYMAACVHDAPLTQADAAAAAGVTVETIRSHRDRLLSIVE
The following text describes a protein:
Function:
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Domain:
The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity).
Sequence:
VPNAQPALEGRTSFPEDTVVTYKCEESFMKIPGKKDSVICLKGSQWSDIEEFCNRSCEVPTRLNFASLKQPYITQNYFPVGTTVEYVCRPGYRRELSLSTKLTCLQNLTWSTAVEFCKKKSCPNPGEIRNGQIDVSNGILFGATISFSCNTGYKLFGPTSSLCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGKRDHYGYRQSITYACNKGYTMIGEHSIYCTVNDDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTSLLSGHKCFTLTGLLGTLVTMGLLT
The following text describes a protein:
Function:
VP10 self-assembles, together with capsid protein VP4, to form an icosahedral caspid of 87 nm in diameter, with a T=43 symmetry and composed of 420 hexamers and 12 pentamers. VP4 proteins arrange into hexons, while VP10 proteins form the pentameric densities located at the 5-fold axes in the virion. The stoichiometry of VP4:VP10 is 42:1.
Subcellular Localization:
Virion.
Sequence:
MLSLDNYSYVHNITTQTNIDLSSQQTIHLASINGKGYIIFLRFFCEGSSACFTNVKFSVKANGLVLYSFRYIQLLELGQAIATAIPSSSQGFSTLLSNYNVLISSPIGTLPQLTLYDSYDNRYGAMLQPAFPLPFVNTLSLDVDILPVSQSSYDPIPYSLNDNQISTNAPTGKGNISIEYLLYNCLV