lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling. Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation. Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus. Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity).
Subcellular Localization:
Membrane, clathrin-coated pit. Early endosome. Recycling endosome. Note=Also found on macropinosomes.
Sequence:
MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPICLGLVEGVIGKIQLHSDLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDLELELCKKHHFGINKPEKIIPSPDDSKFLLKTFTHIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQDLTEIGTPDVDFWIIPMIQGFVQIEELVVNYTESSDDEKSSPETPPQESTCVDDIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGYRYNPRPRLDRSEKETVAYFCAHFEEQLNIYKKQVIINLVDQAGREKIIGDAYLKQVLLFNNSHLTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKWCWVDEAGVICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPVKCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQAVIDLMQGIPVTEDLYSIFTKEKEHEALHKENQRSHQELISQLLQSYMKLLLPDDEKFHGGWALIDCDPSLIDATHRDVDVLLLLSNSAYYVAYYDDEVDKVNQYQRLSLENLEKIEIGPEPTLFGKPKFSCMRLHYRYKEASGYFHTLRAVMRNPEEDGKDTLQCIAEMLQITKQAMGSDLPIIEKKLERKSSKPHEDIIGIRSQNQGSLAQGKNFLMSKFSSLNQKVKQTKSNVNIGNLRKLGNFTKPEMKVNFLKPNLKVNLWKSDSSLETMENTGVMDKVQAESDGDMSSDNDSYHSDEFLTNSKSDEDRQLANSLESVGPIDYVLPSCGIIASAPRLGSRSQSLSSTDSSVHAPSEITVAHGSGLGKGQESPLKKSPSAGDVHILTGFAKPMDIYCHRFVQDAQNKVTHLSETRSVSQQASQERNQMTNQVSNETQSESTEQTPSRPSQLDVSLSATGPQFLSVEPAHSVASQKTPTSASSMLELETGLHVTPSPSESSSSRAVSPFAKIRSSMVQVASITQAGLTHGINFAVSKVQKSPPEPEIINQVQQNELKKMFIQCQTRIIQI
The following text describes a protein:
Function:
Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ufm-1, a ubiquitin-like modifier protein bound to a number of target proteins. Required, with oct-4, for the localization of a subset of 7 transmembrane domain odorant receptors, including odr-10, to the cilia of olfactory neurons AWA and AWC. Operates in aggregation behavior, and responses to oxygen levels.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Note=Recruited to the endoplasmic reticulum upon interaction with odr-4.
Sequence:
MTNSQTVSLIGPTQMAPQSTPPPPVNELWFIDAQAMFQNYANLRSFSKSNANEINTTIGGFVFGRKARKQVIHVLFAYAEDLTESNRQFLESSLSADIELVGNLNIDGQSQILPGGQFTLQLTSRMLENRSISEFLDMNVMFNNEHVLMEGASCVSRVGYEWSLRAGREQEDVKSAAERLSMASFRFTYLNAEHGLVIREQKPEAAQQKYLDKFSKGAVPYKDVIEFTAMQSLTRDTSNDTEDQKLVPTVKVTKDNKHFTRLVTIGEVVFPAFFGDSSLDLYKRSREAFNRRANNTMMVTVNGIRAGRGVTTTTSATYLPPGWVSLLHLQLPTKWTDNEQRNYRIRLHKLFNLPSSKPVLRLSQALALHSESARLTNKKLIREPHLSITNYQPVGEITTVNGPYNYHHYMQDGIDDSGWGCAYRSFQTIWSWFILNGYTDKPVPSHREIQQALVDIQDKQAKFVGSRQWIGSTEISFVLNELLKLECRFIATNSGAEVVERVRELARHFETSGTPVMIGGNMLAHTILGVDFNDTTGETKFLVLDPHYTGSEDIKTITSKGWCAWKPASFWSKDHFYNMVLPQPPSDAI
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit H is essential for V-ATPase activity, but not for the assembly of the complex. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein.
Sequence:
MTKMDIRGAVDAAVPTNIIAAKAAEVRANKVNWQSYLQGQMISAEDCEFIQRFEMERSPEEKQEMLQTEGSQCAKTFINLMTHICKEQTVQYILTMVDDMLQENHQRVSIFFDYARCSKNTAWPYFLPMLNRQVPFTVHMAARIIAKLAAWGKELMEGSDLNYYFNWIKTQLSSQKLRGSGVAVETGTVSSSDSSQYVQCVAGCLQLMLRVNEYRFAWVEADGVNCIMGVLSNKCGFQLQYQMIFSIWLLAFSPQMCEHLRRYNIIPVLSDILQESVKEKVTRIILAAFRNFLEKSTERETRQEYALAMIQCKVLKQLENLEQQKYDDEDISEDIKFLLEKLGESVQDLSSFDEYSSELKSGRLEWSPVHKSEKFWRENAVRLNEKNYELLKILTKLLEVSDDPQVLAVAAHDVGEYVRHYPRGKRVIEQLGGKQLVMNHMLHEDQQVRYNALLAVMELMVHNWELAKQMQSRLPQ
The following text describes a protein:
Function:
Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.
Subcellular Localization:
Nucleus.
Sequence:
MVPDTEFSEALSKPLNVIQQIHNDAQDKSPSNITKLVETHFRHLFASPDASAKIPLLSPDNISQLLPPLNTDAPIAHRLVRFRAMIQDTGLGTEVFLAKHQHAGRTFTGLYGGEASIGNSSDSSNQADHNELDHQNLAERTVMYVVSLPGQSVWAANAHREAIAGPNSDPSLDELVMDTSAVSLNEAVSPKRVQEVRERIRKAVAKGKKIGSAGKEPRLVAISKLHPPSAILAAYRQAGQLHFGENYVQEMVDKAKVLPREIRWHFVGGLQSNKGKLLASIPNLYLLETLDSVKAANVLQKALASPDAAKRDEPLRVYLQVNTSGEEAKSGLAPILAVDAEQARESDLLQLAVHVITKCPNLRLRGVMTIGAAANSSSADAEAAKSVDEIVSANPDFERLIQTRANLVQLLRKSEKVQTADASHIKEAYSELLDGSDAHGGLELSMGMSADMDVATMAGSDNVRVGTDCFGRRPATREEAMSAMKHELEVGPEAAAAESTHQRGSQSLLASSTTADARMPNLCRAYLAKSPLPDTPHVGGLVKLYDLDAAEKFKTTELIEVVGILETAALPQAEWQDTGSAAASSSEPAQVPCIHAIYAAPAELDSIGSEESSSTPDANVLSQPTQRQALIDFLAGALGGDKVAAELVLLAVIARIHVRRANLCLGALTLNVSNFAAPPSSSSQTQLSLRLKQLLPAVVDVSMDLGALNDDKRPLYPKSAGGATGLEAGQLQLVNGTTILVNEGAMGEGQLKDTGIHNIKALSSVLESYKLPYAFPYSEFEFDTDLNAVILSQGKSFLPFDVQCPLQPMDGAVELYSSSLPQVDQAQLWTWRKALSNARNLATAKAFVIPESVSEHIQQEFVAERRKEQEDAKHSHGGVGSKAEGLGQEDLLRRMSIVRLLALSYGEKSLSIETWSKAVELDKLLAQRVTAVQQQQQRSQHASATMSGAASVSR
The following text describes a protein:
Function:
Has strong antibacterial activity against P.aeruginosa.
Subcellular Localization:
Secreted.
Sequence:
MLQLWKLVLLCGVLTGTSESLLDNLGNDLSNVVDKLEPVLHEGLETVDNTLKGILEKLKVDLGVLQKSSAWQLAKQKAQEAEKLLNNVISKLLPTNTDIFGLKISNSLILDVKAEPIDDGKGLNLSFPVTANVTVAGPIIGQIINLKASLDLLTAVTIETDPQTHQPVAVLGECASDPTSISLSLLDKHSQIINKFVNSVINTLKSTVSSLLQKEICPLIRIFIHSLDVNVIQQVVDNPQHKTQLQTLI
The following text describes a protein:
Function:
Degrades abnormal exported proteins and responsible for the propeptide processing of a natural pro-protein and for the maturation of a native protein. It also plays a prominent role in stress (heat shock, ethanol, puromycin and NaCl) resistance during active exponential growth.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQSANNSRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKDNSQSSDFSSIFGGNSGSSSSTDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKASVVGYDEYTDLAVLKISSEHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTNINAIQTDAAINPGNSGGALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLEADGKISRPALGIRMVDLSQLSTNDSSQLKLPSSVTGGVVVYSVQSGLPAASAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSNTADVKLSKSTSDLETSSPSSSN
The following text describes a protein:
Function:
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein; Cytoplasmic side. Membrane.
Sequence:
MQKAFRNVLVIVIIGVIIFGLFSYLNGNGNMPKQLTYNQFTEKLEKGDLKTLEIQPQQNVYMVSGKTKNDEDYSSTILYNNEKELQKITDAAKKQNGVKLTIKEEEKQSVFVSILSTLIPVVVIALLFIFFLSQAQGGGSGGRMMNFGKSKAKMYDNNKRRVRFSDVAGADEEKQELIEIVDFLKDNKKFKEMGSRIPKGVLLVGPPGTGKTLLARAVAGEAGAPFFSISGSDFVEMFVGVGASRVRDLFDNAKKNAPCIIFIDEIDAVGRQRGAGVGGGHDEREQTLNQLLVEMDGFGENEGIIMIAATNRPDILDPALLRPGRFDRQIQVGRPDVKGREAILHVHAKNKPLDETVDLKAISQRTPGFSGADLENLLNEASLIAVREGKKKIDMRDIEEATDRVIAGPAKKSRVISKKERNIVAHHEAGHTIIGMVLDEAEVVHKVTIVPRGQAGGYAMMLPKQDRFLMTEQELLDKICGLLGGRVSEDINFNEVSTGASNDFERATQIARSMVTQYGMSKKLGPLQFGHSNGQVFLGKDMQGEPNYSSQIAYEIDKEVQRIVKEQYERCKQILLEHKEQLILIAETLLTEETLVAEQIQSLFYEGKLPEIDYDAAKVVKDEDSEFNDGKFGKSYEEIRKEQLEDGQRDESEDRKEEKDIAEDKKEADKSDEKDEPAHRQAPNIEKPYDPNHPDNK
The following text describes a protein:
Function:
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MEKKQSILSPIIRITFTFLVLCGLVYPLIVTGIAQAVMKDNADGSLIYNDKNEVIGSKLIGQNFTDPRYFQGRVSSIEYKAEASGSNNYAPSNPDLEKRVEKSIEEWKKQNPSVPVTEVPIDLVTNSGSGLDPDISPKAASVQVDRISKLTDIPKEKLNQLIKDQTEGAALGLFGETRVNVLKLNLALQELMK
The following text describes a protein:
Function:
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MSRHSATANFDSHSSRLTKDLPAAMEDPGMSRMQELLSSYYGLQDQESRQGQLRNIDSPGFDPKIYVKVRNSVLEDSELLETRGLNDLLTTDDQLIREIKELDTNMQMLVYENYNKFISATDTIRKMKNNVASMEDEVGRVVKSMDTITAKSESINVALAPHRSKVEKLIGVRRLLKRFEFIFDLPQRLNTAVKQKEYANATKYYLLARRILGRYEHISSFKTIQLEAEKIIQQLERLLKKRMLDTTLESEEVCETVVLLHQLDACNEDIRDQFLEWHQAYFECAVAEFKSQGTVDSVLNFLQSFNTDVFAKMGRVFSVYKTHFMPDVVAREKSSTSRKSSDAIRDDLFLSFVKELFALYLSECVAQFRRPHTEFGSTDEVLDVLQDDDLSSEIVDMKAVDTSIPMCRLATSATEVVENCVRFQIEGVFRKLREDTGELFCTSHEDVSSLVRSSRDGGQNIQPLAQESAKKFTDMMQKVLQQMEPMVQTGFAILSEMSRLFSDLVQGQFYDFLKWFNASVLRYAEPKRAFTPADDPQGTRGEEQDGVTLPWLEPTPQFLLFLACMCQELSAEGIGECVRGLIECLPAPLSPSRTSEGEPIRSRRMNQQDVTHMIEVTRESSAELLQHVAKQYGNQLCIIVHNGVAATSWADMDEEPRSVQEMMAAVVEATFRFGKEVALALGDEQSVFIGNNSRTTSRDFRRRASALRSRNAGVAGASSGMQLDVDRIFARKIHISPSQVELTADAFVQTMLKMCIKAFSEWVRLLELSKFGLQQIQLDAEFLRSTLMHIVVAGGAEEEVESLLSDLLSNARARAVEDVLMEQSNVVAIVSTKSTQVLSRRG
The following text describes a protein:
Function:
Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MTSQGPLYIGFDLSTQQLKGLVVNSELKVVHISKFDFDADSHGFSIKKGVLTNEAEHEVFAPVALWLQALDGVLNGLRKQGLDFSRVKGISGAGQQHGSVYWGENAESLLKSLDSSKSLEEQLSGAFSHPFSPNWQDASTQKECDEFDAFLGGPEQLAEATGSKAHHRFTGPQILRMQRKYPEVYKKTARISLVSSFLASLLLGHIAPMDISDVCGMNLWDIKKGAYNEKLLGLCAGPFGVEDLKRKLGAVPEDGGLRLGKINRYFVERYGFSSDCEILPSTGDNPATILALPLRPSDAMVSLGTSTTFLMSTPNYKPDPATHFFNHPTTPGLYMFMLCYKNGGLAREHVRDAINEKSGSGASQSWESFDKIMLETPPMGQKTESGPMKMGLFFPRPEIVPNVRSGQWRFTYDPASDALTETEDGWNTPSDEARAIVESQMLSLRLRSRGLTQSPGDGLPPQPRRVYLVGGGSKNKAIAKVAGEILGGSDGVYKLDVGDNACALGAAYKAVWAIERKPGQTFEDLIGQRWREEEFIEKIADGYQKGVFEKYGKAVEGFEKMEQQVLKQEAARK
The following text describes a protein:
Function:
Component of histone acetyltransferase complex. Within MSL complex, promotes ubiquitination of histone H2B.
Subcellular Localization:
Nucleus. Nucleus, nucleoplasm. Nucleus speckle.
Sequence:
MTLRSIVIKSGGHRLDTSLIKKPAEINEYLASLKKETCDFATYVLCSICNSIIQKHQVQSKAKISCRKVLSCPDQSSAGGLGHKNWEPSGALILPSTKQMGAEGSPVKSRSLFCQTNHNHLVNMDPMVSNDNNQQREGEQVGAMVGDSSPEDSPSGKHWNVRKGSGLVDPQTSCIRQILLLQLELIEQQQKHLHNKNKEIEDLKAEKEMLMARIERMEHRLQMVKKDGVVSRPSQTTCHKEPEAETTTSDDVQHSGGRVQTPKQTQRGRGVKGSKGKFLLQDSPTGRSRRGQPRSPPTSQQESPALKEDMQCHSKEVPYLTTTEMYLSHWQTPPSPQRDPSTVHENTVEVPSWRESILEPLGQKEASDILECLDDSVFLKRHSKLELDEKRRKRWDIQRIREQRMFQRLQQRMNRRKVIQESEPELLSFHAEPEDVEYIMVTPFLPVVAFGSPLPNLKQQDFDLPWLDERSRCQPEVTKKRTPRRRCRK
The following text describes a protein:
Function:
Involved in the perception of CLV3 and CLV3-like peptides, that act as extracellular signals regulating meristems maintenance.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MMIRSHRHWVFSSRIIIFLSLLVHSLASSSPHFCRDDQRDALLEFRGEFPINASWHIMNQWRGPWNKSTDCCLWNGVTCNDKSGQVISLDIPNTFLNNYLKTNSSLFKLQYLRHLDLTNCNLYGEIPSSLGNLSHLTLVNLYFNKFVGEIPASIGNLNQLRHLILANNVLTGEIPSSLGNLSRLVNLELFSNRLVGKIPDSIGDLKQLRNLSLASNNLIGEIPSSLGNLSNLVHLVLTHNQLVGEVPASIGNLIELRVMSFENNSLSGNIPISFANLTKLSIFVLSSNNFTSTFPFDMSIFHNLEYFDVSYNSFSGPFPKSLLLIPSLESIYLQENQFTGPIEFANTSSSTKLQDLILGRNRLHGPIPESISRLLNLEELDISHNNFTGAIPPTISKLVNLLHLDLSKNNLEGEVPACLWRLNTMVLSHNSFSSFENTSQEEALIEELDLNSNSFQGPIPYMICKLSSLGFLDLSNNLFSGSIPSCIRNFSGSIKELNLGDNNFSGTLPDIFSKATELVSLDVSHNQLEGKFPKSLINCKALELVNVESNKIKDIFPSWLESLPSLHVLNLRSNKFYGPLYHRHASIGFQSLRIIDISHNNFSGTLPPYYFSNWKDMTTLTEEMDQYMTEFWRYADSYYHEMEMVNKGVDMSFERIRRDFRAIDFSGNKINGNIPESLGYLKELRVLNLSGNAFTSVIPRFLANLTKLETLDISRNKLSGQIPQDLAALSFLSYMNFSHNLLQGPVPRGTQFQRQKCSSFLDNPGLYGLEDICRDTGALNPTSQLPEDLSEAEENMFNWVAAAIAYGPGVLCGLVIGHFYTSHNHEWFTEKFGRKQHKALTSVKCSL
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSVVNDDFKPLLIQWVEEEAINATKRGSKMVDLYNKILFQLRGYELPICDLKTLKSIKYVGDKTANQLRKKIAKHCKENELTLPRGFMDVAEKHRLDLEESNLTSSTSTIKTTNKRAKTSSKSKPKYVPKHRSGGFAILIALYLYDKDRNGMTKERIIAGATPYCDRSFSNNAASKEFYSAWSSAKTLENHNLISTTGRSPKIYFLTDEGVSLAQQLKTAIGLSSPPEGSKKNDRNMIMEQSFDNGIRLDTSFELSSPAGRAMLSSSPIRRISNPVHSNRAIQKMLEKELRNGETPPSSQHDAGNRIYDGIKYEVWRKEDYEVIVYMDNREIRSRADRDHFQTRLQTLGVKCEVKPLSSGDVLWVGRNTSTGTEAVLNYLCERKRLDDLCDSIKDGRFQEQKNRMKKTGIKHCYYLVEDMVSYQDKVYDLMDSIQSSLTQTMTTARLYLRRFKDIDETTAFIASNTKVIENLKSNLIVIKPQDIKNQQDYLNILLKFRNKFEKTQPHQDNPDYECVQLFSRFQDMLGKTNQMTVKEMFILMLMTIRGVSLEKAVVIQNRFPTPKSLLEYYHTEHATTDTNIKRDLMMNEFKDQIGNKKIGKALSEKIYNVWGKP
The following text describes a protein:
Function:
Catalyzes the attachment of arginine to tRNA(Arg) in a two-step reaction: arginine is first activated by ATP to form Arg-AMP and then transferred to the acceptor end of tRNA(Arg).
Sequence:
MTANFRLYIANQVAQLLQQEVNLISNQIRVTGRNYKSFGFILPVNNVLTNQLPKGANTFRHSCQTAQNLAQQVQIDNHYIHNVTVDKASIIFQPNHQTLMTEVLNNAMNNNAVTDYSNETKKHILVDYSSPNIAKPFHVGHLRSTFIGNFIANINEYFGNKVTRINYLGDWGVQFGLLGVGFQKFGSTESLINNAIKHLFDVYVQINNEMERDASIQERARLFARRMEEDDEECINLWKQFRSLSIKEYKKIYKDIIEKLRDDGLLVDNRDIVAAIDRFERFNFDEMYYVTSSAQNLHFQHLFKILNLSGYNWVKNCYHVDFGMVKGMSTRTGNVVFLQDILDDAKERMMKTLSRKHNDPSSIAELVGLAAILIQDLKAKRIKDYEFNWEKMLASHGDTGPRLQYEHARLVSIAEKTQVPINMEADITSLLSENSAIKLVEHITRFEGELVRAKLHSEPCFLVNYLFILSHLISAANHNLKVLGQTEKIAEARMLLFAASRNTLAKGLNILGVKPLNKM
The following text describes a protein:
Function:
RNA helicase.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
EAAPLFVKNETFTGIGIDPLLSLHLSKKFEFEKPTLIQKASIPVLLDPTHNDAIIQAQTGSGKTLAFLLPILHSLIRSAARQSTHPTTQHMFSRTAGTFAIILAPTRELAHQISEVLDSLLKYSLQMHYRHWIVSSIVVGGEKRKSEKARLRKGVNILVCTPGRLLDHLRTTDSFDVSNLRWLILDEADNLLHLGFEETLRDILKILDTKRDVGLYNQTRVHVPGWPRGRQTVLCSATIEAGVKRLAEYALVKPNFIRVAAVADTNDAATIPKQLKQSYVLTPPKLRLVTLIALLRKITSTPNASKVVVFMATGDSVDFHFDSFIHALDSNDTGAGIDLDAEDEDDKTTYDAVKLKAGVQPTNLFPNVRLFKLHGSMPHAHRQATYTGFCAQSNEDKSILLCTDVAARGLDLPDVAHIVQYDPPGEVRDYIHRIGRTARLGRQGAATLFLMPSELLYLETLKSAGCDLVPTNNLLEFLPQCKFGGVLESYTTHANGKPKRKTFEVAATDLHMAFERHIMASPSSNKAAQKAYTSQIRAYATHTVAERHIFHIKNLHLGHWAKSFALREAP
The following text describes a protein:
Function:
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular Localization:
Cytoplasm.
Sequence:
MTAPGPACSDTPIAGLVELALSAPTFQQLMQRAGGRPDELTLIAPASARLLVASALARQGPLLVVTATGREADDLAAELRGVFGDAVALLPSWETLPHERLSPGVDTVGTRLMALRRLAHPDDAQLGPPLGVVVTSVRSLLQPMTPQLGMMEPLTLTVGDESPFDGVVARLVELAYTRVDMVGRRGEFAVRGGILDIFAPTAEHPVRVEFWGDEITEMRMFSVADQRSIPEIDIHTLVAFACRELLLSEDVRARAAQLAARHPAAESTVTGSASDMLAKLAEGIAVDGMEAVLPVLWSDGHALLTDQLPDGTPVLVCDPEKVRTRAADLIRTGREFLEASWSVAALGTAENQAPVDVEQLGGSGFVELDQVRAAAARTGHPWWTLSQLSDESAIELDVRAAPSARGHQRDIDEIFAMLRAHIATGGYAALVAPGTGTAHRVVERLSESDTPAGMLDPGQAPKPGVVGVLQGPLRDGVIIPGANLVVITETDLTGSRVSAAEGKRLAAKRRNIVDPLALTAGDLVVHDQHGIGRFVEMVERTVGGARREYLVLEYASAKRGGGAKNTDKLYVPMDSLDQLSRYVGGQAPALSRLGGSDWANTKTKARRAVREIAGELVSLYAKRQASPGHAFSPDTPWQAELEDAFGFTETVDQLTAIEEVKADMEKPIPMDRVICGDVGYGKTEIAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFGERMSGFPVTIKGLSRFTDAAESRAVIDGLADGSVDIVIGTHRLLQTGVRWKDLGLVVVDEEQRFGVEHKEHIKSLRTHVDVLTMSATPIPRTLEMSLAGIREMSTILTPPEERYPVLTYVGPHDDKQIAAALRRELLRDGQAFYVHNRVSSIDAAAARVRELVPEARVVVAHGQMPEDLLETTVQRFWNREHDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLRGRVGRSRERGYAYFLYPPQVPLTETAYDRLATIAQNNELGAGMAVALKDLEIRGAGNVLGIEQSGHVAGVGFDLYVRLVGEALETYRDAYRAAADGQTVRTAEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDREVAAVVDELTDRYGALPEPARRLAAVARLRLLCRGSGITDVTAASAATVRLSPLTLPDSAQVRLKRMYPGAHYRATTATVQVPIPRAGGLGAPRIRDVELVQMVADLITALAGKPRQHIGITNPSPPGEDGRGRNTTIKERQP
The following text describes a protein:
Function:
Catalyzes the 3'5'-hydroxylation of naringenin and eriodictyol to form 5,7,3,'4',5'-pentahydroxyflavanone and 3',5'-hydroxylation of dihydrokaempferol and dihydroquercetin to form dihydromyricetin.
Sequence:
MASLDHLFLLKEIAMSILIFLITHLTIRSHFTNRHNKLPPGPRGWPIIGALSLLGSMPHVTLSRMAKKYGPVMHLKMGTKNMVVASTLLQLPPNAGATHLAYDSQDMVFAHYGSRWKLLRKLSNLHMLGGKALDGWAQVREKEMGYMLGSMYDCSKKGEVVVVAEMLTYAMANMIGEVILSRRVFETKDSESNQFKDMVVELMTFAGYFNIGDFVPFLAWLDLQGIEREMKTLHKKFDLLLTRMIKEHVSSRSYNGKGKQDFLDILMDHCSKSNDGERLTLTNVKALLLNLFTAGTDTSSSIIEWALAEMLKYPNIIKRAHLEMVQVIGKNRRLDESDLKNLPYLQAICKETMRKHPSTPLNLPRVSSQPCQVNGYYIPKNTRLSVNIWAIGRDPEVWENSLEFNPERFVSGKGAKVDARGNDFELIPFGAGRRVCAGTRMGIVMVQYILGTLVHSFEWKLPHGVVELNMEETFGIALQKKMPSQTKYIALIPYEFNYNKKGTSRYPTRANQTMC
The following text describes a protein:
Function:
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Shuttles between the cytoplasm and nucleus.
Sequence:
MFGMLSSSFEDDPFFSDSFIAHRESMRQMMRSFSEPFGRDMLSISDRRGRARNRMGHEDEENSLTHTDVSPFQAMDRMMLNMRNSMQELQRNFGHLSMDPNGHSFSSSSVMTYSKVGDEPPKVFQASTQTRRAPGGIKETRKALRDSDSGLEKMAVGHHLHDRAHVIKKSKNNKTGDEEVNQEFINMNECDAHAFDDEWQNEILKYQPRGQWRNLDNSRMRSVAHENSGSRELKRREKHHQSPAIEHGRRSNVFVDKLNIKGSPVKINKK
The following text describes a protein:
Function:
Involved in the Ran-GTPase system for nuclear protein import and poly(A)+ mRNA export. Required for mitosis-to-interphase transition.
Subcellular Localization:
Nucleus.
Sequence:
MVQLFGGALCADFPPKFLDASVLRQIPDNQEVFLQDSKENLTVIIELLEKIEKPFDGSVAAYHFNSIAFDNDASQRVIWRDKSLGEDDFEGMRSEKASGSSVQGCQRVLEKGKRNPESATNVAIFVNVITLIDFQTDIVISVNAPLPNTSSVPSSVENIPPSDQSIVRAALETIQRVTRSLVLVDKTVFA
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MMDLKEWSSSSEELNVNRKCCADCKTTKTPLWRGGPAGPKTLCNACGIRYRKRRACWRKGELKKQKQKQKQRWKMLGEEEQAA
The following text describes a protein:
Function:
Carcinine transporter which is required for recycling of the neurotransmitter histamine in photoreceptor neurons of the compound eye. Following histamine release from photoreceptors and its uptake by glia where it is converted to carcinine, required for the uptake of carcinine from glia into photoreceptor cells where it can be hydrolyzed by tan to form histamine and beta-alanine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Note=Expressed predominantly in photoreceptor axon termini.
Sequence:
MSDIEDNDGDEYDELSELRQRHKPESQPSVDEAFDLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDLPLEQRKSLSIPKELDNDELVYSKCYTYGVNWTQLLESGEEDDLTTMEPNASWPLIKCPQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEEGEEFGKNWQFKDCCRCAQKPEILSQPASYENLDVLAGSSTNASEVELELRDSRRVREPAPRIDERTPLDTTASGSGRPVHRPSMKRLVRQMSVMDTQRTHDGTMQLTHWI
The following text describes a protein:
Function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
ALQGKIIPFNLSDIGEGIAEVTIKEWYARPGDKVSQFESICEVQSDKASVTITSRFDGVIKKLYYEVDDIAKVGQPLVDIELSEESPSPPVTAPASSVNKGGKVLTTPAVRKIAMENKIDLSEVPGTGKDGRVLKEDVVLFIHNRRAPPPAPPPQPAPAISPSAPAISPPAPVFIPHMALEDRVENIKGIRKAMAKTMTAALNIPHFGYCDEILLNELVDFKKHINPMLEQRGVKLSFMPLFIKAASMALQQFPILNSSVDPECTKITFKAAHNIGLAMDTPQGLVVPNVKNVQLKSVFEIAVELKRLHQLGLKGQLGTEDMTGGTFSLSNIGSIGGTYAKPVVLPPEVAIGALGKIQVLPRFNSNGDVYKAHVMNVSWSADHRIIEGAVMCRFSNLWKSYLENPASMMIDMR
The following text describes a protein:
Function:
Cilium-specific protein required for the stability of the ciliary architecture. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (Probable).
Subcellular Localization:
Cell projection, cilium.
Sequence:
MKTKMIVSTSMNAGEGTRTEAEDTSKGVASLADLDSQSAAAEVSESDIKPSGPRITKDFLREHCKKNKLYLTPRLNDTLYLHFKGFSCIEGLEEYTGLRCLWLECNGIRKIENLENQTELRCLFLHQNLIHTLENLEPLSKLCTLNVSNNYIKVIENISSLSDLSTLQISHNTLGNVCDMEELSHCPSISVLDLSHNRISDPALVNILEKMPDLRVLNLMGNEVIKKIPNYRKTLIVRLKQLTYLDDRPVFPKDRACAEAWAAGGLEGEQKEREMWQTRERRKIQESLDAMTAIRETALKRRQDRELSEKGIIEFPSPVAEDQSPHDEISDIEPAESDSDSETTQEQTDASPSPSEMDHNFNSASDDSDQSQPQPNESVHSSFDEEQIRQSATWGLKPKEEKNQILSIYTKPSQSDQRVLISVSGPGALVTELISEDEIESINLSDEPVLTIDDLPDLEDEENSHILPITSQSGMRPKIEVISSIDTESEAVRSLYPWPHSDAVALDQSQQLISVSTTRNSVKQQSTAFTSLAEAGDDVPKAAEKRKTVLIEELD
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes; Regulates also the sphingolipid metabolism.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPVCIECGHGVPRIIKPDTETVERCGMCGRICDICYEFGDVQIWIDVVLLRHRAWAHVLFNQTDYYTKLVIFVLCCVVEAVVVHSLTVLKAIPFFTDDLENSSLYTPERQVRSLQLVRIIQSSFLPLMNYPSAIFHIFVFTFTENALVASIATWLGRFFYRSYGHRERLWFVEAALASYAKLSYALFLIWAIPPSMLPMVDVLYVLWLGCAFTVLGFDRHWMYPVVTVLVCVCARGLFRYLTKWSPQVLY