lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Developmental regulator acting by forming heterodimeric complexes, that sequester CO and CO-like (COL) proteins into non-functional complexes. Involved in the CO-mediated long-day flowering-promotion pathway. Engages CO and the transcriptional repressor TPL in a tripartite complex (By similarity).
Sequence:
MCRGLNNEESRRSDGGGCRSLCTRPSVPVRCELCDGDASVFCEADSAFLCRKCDRWVHGANFLAWRHVRRVLCTSCQKLTRRCLVGDHDFHVVLPSVTTVGETTVENRSEQDNHEVPFVFL
The following text describes a protein:
Function:
Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MEDSDYESLPTERVSVHLLAGGAAGVMEHCVMYPVDCVKTRMQSLKPNPNAQYNNMIHAIKKMIQSEGILAPLRGINIVAMGAGPAHALYFSSYEAIKKLLIGNNTTHSPTAYVLAGACATVFHDGAMNPIEVIKQRLQMYGSPYRGVIHCATSVFKEEGIRAFYRSYTTQLSMNIPFQTLHFTVYEYARKALNPLGGYDPKTHVIAGATAGAVASAITTPLDVAKTLLNTQERSVVNLVGTPKGHVYYVSGMFTAFRTIYQMRGFPGYFQGLQARVIFQMPSCAICWSVYEFFKHFLHLTTEESEYHEIPATQGN
The following text describes a protein:
Function:
Serine protease inhibitor that inhibits trypsin at a molar ratio of 1:1.
Sequence:
LLTNTFCFFFYSATTHAWIEKELEEEYRGVDFDLGCRPAPVSGLCRAYFERWYFDVSTGSCERFVYGGCGGNANNYKSQRECEVACLR
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MQRSQLARKFATQVGAYSLLRGRCHAVSTWKVMATQAVTIPMYLPVRFHSEGHAAGEEAGRTGQYLLNKDDVLTRVLEVVKNFEKVDASKVTPQSHFVNDLGLNSLDVVEVVFAIEQEFILDIPDHDAEKIQSITDAVEYISQNPMAK
The following text describes a protein:
Function:
Removes the phosphate from trehalose 6-phosphate to produce free trehalose. Trehalose accumulation in plant may improve abiotic stress tolerance.
Sequence:
MLCTCPLLAVTLLNYCPWSGPVRYRSLPLRDINRVFRLLSWLRFMHVCSDEKIPVFFIDKRTSHNSPVFVDPLPSLALPMTYTTPTSFPSSGLYLNTPKKKPLPSKIEEVRAAGWLDLMLASSPPRKRQSKDFLPHDVQADDLDLRYRNWMVNYPSALGSFEAITELARGKKMALFLDYDGTLSPIVDNPANAVMSDEMRAAVRHVASLFPTAIISGRSRDKVFDFVKLTELYYAGSHGMDIMGPIRKSESNGHHVECVRSTDSEGKEVNLFQPASEFLPMIAEVFENLSESIKDIEGARMEDNKFCVSVHYRNVAPHDYETVHQRVTAVLKDYPCLRLTHGRKVLEVRPVIDWNKGKAVEFLLESLGLNESDDVLPIYVGDDKTDEDAFKVLKANNHGFGILVSSVPKDSDAFYSLRDPSEVMEFLRTLAAWKEGSS
The following text describes a protein:
Function:
Involved in endocytosis.
Sequence:
MANKNMRNTTTKVEALIESCRSEGKWHRVIELTDELKTGSPHNECLANFLVGEARLESYLEENALASDSNFGRAKSGLAEARRFLHLALGESGQKAGIALDAYLLLAKLCFACGEYEQSLDNFVKAELNTLAEKELTLRSLKILAESYAIKGLCLEQQTTKPSSKFKKAEKDTEMISCFERASDLGLLYLQEYDLVSGSSGSSNNSTAGSTLNVNASTVQPSSSSFAISSTIPASGPSGLEMNRRMGAILETALQRAPIVLIKTEKLQEAVERYRIMLNAIETRATQSLRLTLARQLAEVLLRGVSGTIYSPPFTGKSGGGTLRGGSSKKLWKPRKYAARQQFNPRNQQEEVILLLLIAEALAVRDTVLSQSPEFRQARQHAMGNVTAVYDLLTLATVRWGLVQLLNESFEKALKFSFGEQHVWRQYGLSLMAAEKHSHALRVLQESMKLTPSDPLPCLLASRLCYESLETVKQGLDYAQQALKREVKGLRPSRSQLFVGIGHQQLAIQSNLKSERDACHKLALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLEDAETALGTVQHMLAVWRDVYEAQLAGEEEKHSDTKSGVHLAHSSQMSDKDSNSVYAASLAAVSRVEQALSEAASSLSSFTQRPGPRRPWMLQIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPSCPVLPFTSIPLVFE
The following text describes a protein:
Function:
Ubiquitin-protein hydrolase which cleaves ubiquitin from ubiquitinated proteins. Plays a role in embryo osmoregulation. Probably by regulating osmosis, controls actin redistribution in the 1-cell embryos and thus actin-dependent processes such as cytokinesis and P-granules segregation. During the first embryonic mitotic division, involved in the formation of a functional microtubule organizing center provided by the male pronucleus. Acts as a positive regulator of the mTORC1 signaling.
Miscellaneous:
MISCELLANEOUS: Binds Ca(2+).
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center. Note=At the 2-cell stage embryo, localizes to the microtubule organizing center during mitotic metaphase. Localizes to the cytoplasm in germ cells and sperm, and to the nucleus in oocytes.
Sequence:
MGNTLTGRSNAIAPIISAEDAKTYISDEEYRRIRQAFQRFKNGCINYDEFCYHVLGGAQIPEEKRRLLFSFFSHGAETISFDNLLSSLVGLCRVEEVQSRFIEEYHEFASWGLSPPKLTIPLNDSYISFYEVMSYVTHLSVNEVIELEKVFATISDRAVCKLNEEKWKQALGGCFPDSYAERLFAVFDENRDGQIDFRELVCTLSALCRGPLPGRISQLARIWDVDCDKLLSDEELSNMYKDLNVPEEHQTVTKSSNGKSALVDFGIWAQENEKYVNEYYSMALQIGHICLGLRPESRKMELQIVNEFEKRASELPLSEWNIVASGWHAELRSFLEADKNPNPIDNSGIKGTREDSWTSKVACISAESARLKPDLIPSDYIRVPVPLWRAWLRWHGCALTVDSQFTRKYLDGEFFEDNKPALELYPLEILLLGHDRKKSQDGTENTPRSLTSWACAQVSRSMTVDELLALCKTELRLGDGDARLWQVVKENEEGNVLLDDGAQNLHQLYSSLGKTKKVNKMKLLLEVRERGTGVWPEELRASLSGKQITAASTLSSNAQLSDSSGRPGAVGLVNYGNFCYRNAGIQCLARVSPLTQYFLDEDNLDAIKRGNLRRGDAAETTIEYAKLLREMWAAKKKNIAPNDFNDAIRLSSDMFECSEQHDCQEFVAFLLDQLHTSMYESNKSLHPSPEESEGTDSNKLSDSSKKKEADKEEADEEKAERSWTEYEKQNESLVTQLFTGQLRSRLICRTCQSSSSVFEPFTSLSLPIGFEDVDLYQVIVVHRDGRIPRRYGFRLSRDSKVGNLREVVAVSSGISMSHLTIQCMSSKGTLMSRSPNHRSSNLRDELPLSSFPSGARLYALELPESTGEDQWRVAMHRKLQYNHEPYILGSTAGFIVSRFGLPLIVGLDEEVTGKKLYEDVMYQMHRFMEHSVNSSSSRAHDPCEDENSGYPFTLCLVDPNYEWCGQCPALRFCRGCPIRPDESKVFIPANCPIAVDWLPIALYLRYNHSQEQACEDDPSVAETWSRHFAPSSLEHCIEKFSCPETLDAAIQCDRCEKKTMRDKVMTIWKLPKYLIIHLKRFEFLREQGRMGKCKRTVNFPLKHFDPAPFVDKPDGNTYECIALANHYGQLSCGHFIAYAKSNEDKWLLLNDCSVREVSEEEVDKQGAYLLFYERKDVK
The following text describes a protein:
Function:
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
Subcellular Localization:
Nucleus.
Sequence:
MSLPSSSDSSDFEPVPKYLPLKKILEQFRKKKKKQKKKRQRYRKYLVTEKKPHKPPAKKITITLQEKHRRLRERSITFPFTGQKYLQFKRYLPYEQSVFSGFLRYTEKLKYDRHLQNSLKIMDLGEDLENESSEMRKYGYLDDDGPISPIVEQNENTNTNNDEDHSNYDAKIVENNSFILKCTVPSKGKWCIKKKKTNTLNAKPKNLNLQEDGQV
The following text describes a protein:
Function:
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
Miscellaneous:
MISCELLANEOUS: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.
Subcellular Localization:
Cytoplasm.
Sequence:
MNLNKNLPTGTRDKLFREARAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQADAKLYRFFDEKGRLTVLRPDMTLPIGRVVSTTGVMLPLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILIGIGVLNALEIPNFQIELGHAAIYRRVTNLLNLSETAEIDFRLLIQNKSLTGIKRFVADNPSTLDDFILALPRLFGPATAILKQAKNLTTDKGILTALREMETIVEAVSYTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFTSASSPAVGLALNLDSLTTLQNRAGVIKKQVSTSLLIHYDLDAIQQAEKLMQETPNSELSFFETPTNAISFAKKWHIPAVIHVSRQGIQTIFQREADL
The following text describes a protein:
Function:
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity. Directly binds some unknown ligand, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor.
Sequence:
MNFRDNSNIEYRKLDAPLKFINKNYITIGDKDREKYSKILADILEAFRRKMAESDEVYKTFEGAVHYTGSAYDKVKVGKPDEFDLNIVMKLPAAWDYHNDIEVKNSSPSYVTINVKSGCERSYRDPSFLNKYQKGIRIWTDNEGYFIQEQFHAWMEGVVKKALNKFPSHGLEYIIQTNGHAIYVKTKKSGPAVTLQCESQDRKIKIDVDLVPVIQFNNNSSTLWLSPPVRQRPLLCCKKTWCAVPKPKKNNGFTNKNREWRVSFTDQERDLLYNKGRIKNLIRQIKKLKSVHEETKSLPSYYVKTIFLWALDDKSLDQNMWTQWSDGALFMFMLKRLHSHLDENKIPYYWDSRCNLLDALGYAVNNMKYKIQRIIKEIDNSLDNPEVLAKYLLTADEFADFRRRYGSIEEGFESLSIDSAPPVSDLRGDSRCCIL
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MASLNQDQIKILEQSRQRLVQLTRSLASLIGSLNQSDPLPSWSSLQSQAGIISNNLVSISEHLADNKDLLSALVAYPGPSYPGRTQAPTLEQLLRTKLDPRVEDWVSRGRRAGASALEDRGALSESALAELWDWAPVEANQEARRRNWGGNFTLEEREMGIQNVVTGLRRQLEDEDEEASESEEEVEEEEMEVVGVRRRSGAGAGLEFDIAAPAPGSRQQQQQQKAAGPAVPLEDILRYMTTGIPPTQR
The following text describes a protein:
Function:
Membrane-anchored myosin receptors that define a distinct, plant-specific transport vesicle compartment.
Subcellular Localization:
Endomembrane system; Single-pass membrane protein.
Domain:
The GTD-binding domain is sufficient for myosin binding.
Sequence:
MAANKFATLIHRKTNRITLILVYAFLEWSLIFFILLNSLFSYFILRFADYFGLKRPCLFCSRLDRFFDASGKSPSHRDLLCDDHALQLHSKPVEESNCGFGEFHNDLVHRGCCVEKISSSLCAPIESDFGNLDYPIGDEGQIYNGLKFPRSIFVFEEEKVGSVNLNDSQEETEEKKVPQSHEKLEDDDVDEEFSCYVSSFDCKNKEIATEKEEENRVDLPIEVETAESAPKNLEFYIDEEDCHLIPVEFYKPSEEVREISDINGDFILDFGVEHDFTAAAETEEISDFASPGESKPEDAETNLVASEMENDDEETDAEVSIGTEIPDHEQIGDIPSHQLIPHHDDDDHEEETLEFKTVTIETKMPVLNINEERILEAQGSMESSHSSLHNAMFHLEQRVSVDGIECPEGVLTVDKLKFELQEERKALHALYEELEVERNASAVAASETMAMINRLHEEKAAMQMEALQYQRMMEEQAEFDQEALQLLNELMVNREKENAELEKELEVYRKRMEEYEAKEKMGMLRRRLRDSSVDSYRNNGDSDENSNGELQFKNVEGVTDWKYRENEMENTPVDVVLRLDECLDDYDGERLSILGRLKFLEEKLTDLNNEEDDEEEAKTFESNGSINGNEHIHGKETNGKHRVIKSKRLLPLFDAVDGEMENGLSNGNHHENGFDDSEKGENVTIEEEVDELYERLEALEADREFLRHCVGSLKKGDKGVHLLHEILQHLRDLRNIDLTRVRENGDMSL
The following text describes a protein:
Function:
Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein. Note=A small fraction may also be present at the cell surface, where it acts as a B-cell receptor.
Sequence:
MRHCINCCIQLFPEDAHKQQVACQGGPHHSHQACPSCKGEDKILFRVDSKQMNLLAVLEVRTEGNENWGGFLRFRKGKRCSLVFGLIIMTLVMASYILSGAHQELLISSPFHYGGFPSNPSVMDSESPSDVKEHHYQPSVNNISYVKDYPNIKLIIDSIAARNEFTTRQLPDLQDLKRQELHMFSVIPNKFLPTSKSPCWYEEFSGRNTTDPYLTNSYVLYSKRFRSTFDTLRKAFWGHLSHVHGKHFRLRCLPHFYIIGQPKCGTTDLYDRLRLHPEVKFSAIKEPHWWTRKRFGIVRLRDGLRDRYPVEDYLDLFDLAAHQIHQGLQAASAEQTSKMNRIIIGEASASTMWDNNAWTFFYDNSTDGEPPFLTQDFIHAFQPEAKLLVMLRDPVERLYSDYLYFASSNKSADDFHEKVTEALQLFENCMLDYSLRACVYNNTLNNAMPVRLQVGLYAVYLLDWLTVFSKEQFLILRLEDHASNVKYTMHKVFQFLNLGPLSEKQEALMTKSPASNTRRPEDRSLGPMWPITQKILRDFYGPFNTRLAQVLDDEAFAWKTT
The following text describes a protein:
Function:
Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C).
Miscellaneous:
MISCELLANEOUS: In contrast to the T.cruzi proline racemase enzyme, lacks the conserved Cys at position 273 which is replaced by a Thr residue, transforming the racemase activity into dehydratase activity.
Sequence:
MEAALAVTRLPPNDPRTPALSVVDMHTGGEPLRIVHAGCPEVAGPTLLAKRRYMRQHLDYIRRRLVFEPRGHRDMYGAILVPSELPDAHLGVLFLHNEGYSSMCGHAVLALGRFALDFGLVPAPPKGAREAQVNIHCPCGLVTAFVECEGGRSCGPVRFHSVPAFVLASDLTVDVPGHGKVLVDIAYGGAFYAFVSAEKLGLDVCSAKTRDLVDAASALTGAVKAQFKINHPESEDLGFLYGSILTDGKDAYSEEATTNICVFADEQVDRSPTGSGVTARIALQYHKGLLQLNQTRAFKSSATGSVFTGCAVREAKCGDFKAVIVEVAGQAHYTGTANLTVEDGDPLRDGFLLK
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
Sequence:
MMKFSCVRVAMRCSGAHSILERNMLCRIIGRHKCSCLTLENTFKCYDLENGPTMDVELSREDALTMYTQMLELRRFETVAGNYYKERKIRGFCHLYNGQEAVAVGMKQRLRSCDSVITAYRCHAWTYLMGVSLYEIMAELFGVRTGCSRGKGGSMHMYSDKFYGGNGIVGAQVPLGAGIGLAHSYRKDNGVSVVLYGDGAANQGQIFESFNMAKLWCLPCIFVCENNHYGMGTHVKRASAMTEFYMRGQYIPGLWVDGNQVLAVRSATQFAVDHALKHGPIVLEMSTYRYVGHSMSDPGTSYRSREEVQSTREKRDPITSFRSQIIALCLADEEELKALDDKTRKQVDSICKKATTDREVELDELHTDIYAKNVDGKIRGVSGFHLEHIKLAEVCFGKPKKTPASEINDVPVGAEIDVAKAKERKAKQDAKKAKEAKEPKGGDKKGADAKQPKGEGDDGDKKPKPAAQPPTKAPPAPKK
The following text describes a protein:
Function:
Has low dephosphorylation activity on GMP and glucose-6-phosphate.
Sequence:
MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDRPNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRAVRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILSALKRKGHIQWEE
The following text describes a protein:
Function:
Required to anchor microtubules to the centrosome (By similarity). Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including cetn3 and pcnt. Probably involved in the biogenesis of cilia (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Note=Recruitment to the centrosome may require cytoplasmic dynein. The majority of the protein dissociates from the centrosome during metaphase. Also associates with microtubules.
Sequence:
MATGGGPPDEALSDQDLPNWSHESLDDRLNNMHWNGQKKGNRSAEKNKKKFVECDLRLTNDISPESSPGVGRRRARTPHTFPHTRYVSQMSVPEQAELEKLKQKINFSDLDQRSIGSDSQGRATAANNKRQLADNRKPFNFLPSQLNTNKEKSKSPPKREASTRSLTKDFLASALNKDFLSNSQAFLEEESKREPAIDSSQVVSRLVQIRDYITKASSLRDDLVQKKDLSVNVERLSNLIEHLKFQEKSYLKFLQKMLASENEEEDVRTVDSAVGSGSVVESTLLTFDVPSEASDTTGVDPRQEAKEELKNMKKQHALLTRMLQQQEQLRTLKGRQAALLALQHKAEQAIAKMDESVVTETTGSVSGLSLTSELNEELNDLIQRFHNQLHDSEDPPAPDNRRQAESLSLAREVYRSRNSSTSDTPLEDKSPLFNNVGVLLEKKQKMDTLLGELHTLQDQQLNNTAFVASSVSPRRSTEQRTLGSAVSSALTSDNRAARSPVTIGAYQTASVNESEDEENQNPAEKLKKLKEVRKRLNELRELVHYYEQTSDMMTDAMNENTKDEDETEDSEYDSEQEDAEPTTNIRNPQYRSSWAQMNINSNNQSGTNNRDERQLNTECEINNRSAVNLRSFNMPSALDCLYNIEHSDKEEDGNRELDDEDAEDQGSRASLSSQNSVADDVQSVDFEQKFNRLVAAKQKLKQLQDLVAMYGDDSESEPVAPERSFSGDQFPPEATTLKQQPNNTRPNVSKAQKDIALKEQAREKFYESKLQQQQRELSQLQEERKKLIEIQEKIQTLRKACPDLQLSTSSAGTNPANRQNRQMTTTTSTPDVNTNGNIVVPAMPDPEDSSSVDNEVWSEIRKHQILREDLRQRRKQLETLMAEHQRRQGNTETTSAASIRSDDSDTQGLQQQTRTEKTMATWGGSTQCALEEEEEEEEVDDEECLSDVHQIDIEEDEQDNTSCENNSYPQNSIRKTSFNGRSSKDGWKNQCPLSVEGNHRPSPKTRQQQNVSMRRQENYRWMSELSHVEEKEHWQEQIDQIKKQLDYSTSICQTLMRDQQALSYLLQSMITTPYSVMPSNVGASQVQLIMHQLNQCYTQLNWQQSNVLRLKQMLNDLLVQQPQHLQGESHQREDRGSSAPPLTSPNIFPNFSFLPPTMNLLNMPAFGSIPNVVPGMNFNPVFPHGFENFTQNVASHTDTPLQPHDQNTSGKTEYMAFPKPFESHRSNSTEKERNPPKKPDESEQGRRVWVENHQKSDQEKKPACFGAGLSAGGASAKLAEESRKVKQFDEVSVESLSSMPDPVDPTTVTKMFKSRKASAQASLASKDKTPKAKNKKRKVFHQKSKGIKSCGFQAASASSASEPNQTTCKHAQTEEVVVGNVIKTSSAQRVEKESKATEMSSEAGSDVSMFETLRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQKALFALQDIVTRHVSEGNAKKHETCTKALESTGWMASTSELTPSESLVTTDDEMYAKNSDGPVCQEGEQNDGDNISSLSTSSNFEPFATDDLGNTVIHFDQALARMREYERMKSETENGLVADCCNNLNAAASSLEGTNDEARGRAQHSVDDASGIPCPYIDSKQLDRQIKAIMKEVIPFLKEHMEEVCSPNLLTSIRRLVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFSSKKLKDCGEDLLVEISEVLFNELAFFRLMQDLDNNSTAVQGTVSRKPEAVVVLESFTKEADKEEKTCPEENFSATRETDDEDKDKDETETAEENRNFDAEVLSGKSDISEEDDLDESLPVSISFTKAETQALTNYGSGEDENEDEENYEFEARPVDVQTSLETSSEIADETEKEEMEVRPEANIENEKALSLAVNVMGELSIHEDQAKSDCDVLAHPSLLLSNEKATDFSGTALVNNVKSPVDSPGTSGAGSSDTESPVLVNDFETGSGNLSQKSDEDDFVKVEDLPLKLSLPQEQIMKDIEEEENKNNLCDEILNINDEENGADQLAGDPLALKEPDSPAIHPA
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
Subcellular Localization:
Nucleus.
Sequence:
MGIPNLLRFMKPFIEPVHIKKYAGQRVGIDAYSWLHKGAYSCSMELCMSPRSAGARRYISMPCKSATDEDRHKKRELSLVLGKEKLKQGNTAAAIDLFRKAVQITPSMAYQLIQILKTENVEFVVAPYEADAQLAYLATLDADQGGIAAVITEDSDLIAYGCTAIIFKMDRFGNGEEFIMEKTLETVKDGLCFQDFDQNLFTGMCILAGCDFLPSVPGIGTKRAYSLISKHKNIDLVLSTLKLDKRYSVPDDYIDSFWKTLAVFNHARVYDVKSKSLKHLKPLEERYLNYLAGDLDILGPALAPSMAKAIAEGRLNPVTMETFDEFSRTISLIEFIDTSALNVANQHGSQEILTQESSITICSSEESRDDITACAVDEISSGEQRGNKGVLALGKFLPQKHSSPAVECKEVKPKNTPDNNPFKKRKLPTDQGQVPDQNELLIDLDEEEAVVLCSSLSRESVGPAESLDRNGVSAGLCWPLTQESVASIPNERSSKRQSQQEAFRNKTNKNKDERSGLLKFFMRL
The following text describes a protein:
Function:
Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults (By similarity). Has ribonuclease activity (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Nucleus, nucleolus. Nucleus, PML body. Note=Primarily localizes to the nucleolus. Also localizes to the PML nuclear bodies, when desumoylated.
Sequence:
MAARWAAHGPGPGLDEFTVPAEKRRFLEGSRGRIQGLFEVRLAVLEAQGDWRPALPPPGQPPPAARIWVQLAGGGKAVRSAKEYIKGLCEPELEEKEYYPKDMHCIFVGAQNMFLNSLIQDTCADITVLEIGLLSIKGGAEAVVMAQSQVQQFVKLFENNESLSSECESDIKKQFRQFVEAHADKYTMDLLILPSSLKRELLTLMQTECCESRGAIIDLTGSKSPAELLQDKTSKVILTSRDGKMGDEEERNNAGTPVTELTKQMDNVFSDAPETSFVPINVVPPLEAMTSKERQSCKRRFSDAEESLPKKQLSLENDQEVKSVSHNDSSKRDAVIDLISDSSGELDDPSYCIKEGDDISEEIEYKILVNFFRTMGYSQSIVEKVIGVLGQSVEPLTLLEEIEKENLRFQKEQEWSSKTPKTTNLRLGSNANSSHKLEDEDISCKKNPLKTTHTSNETRTERHKARDMPSTQVDAEDKMHVSVCKPVSPDKSSAICYKKTDIYCPGKNHNSTSSDAETDGFVPLSPPQAGAPKDVDFVARGSSDVRCTSAKSKTAVHQKSAGPSPVQNSHSVVEDQLGHCSSYQVRSPNQHTSQMSNFENPTQAHVLSSEIHSANPDREVSGSHRRHIDPSITGVQRFLESLKKPYRLELKNEPGKPYLKHIIIDGSNVAISHGLRKFFSCRGIAIAVDYFWKRGHRNITVFVPQWRTRRDPSITEQDFLTQLEDVGILSLTPSRMVLGARIASHDDRFLLHLADKTGGVIVTNDNFREFVTESLAWREIIQKRLLQYTFAGDIFMVPDDPLGRNGPRLDDFLQSEGCSRDFLSAQKALQSREQYSSETPLFMHVPNPASSSQQPKNRAHGDHSAAWLPLDTNMKACLSIPPQRSASETVWLREALIKIFPDYEQRQKIDKILADHPFMRDLNALSAMVLD
The following text describes a protein:
Function:
Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Nucleus. Nucleus, nucleolus. Nucleus matrix. Membrane. Note=Translocates from cytoplasm to membranes and nucleus upon cAMP treatment.
Sequence:
MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKVETEKQSPPHGEAKAGSGTLPPVKSKTNFIEADKYFLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTGRAPDSTTPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMERERHRQQQHLLQSPVSHHEPESPHLRYLPPQTVDHINQEHEGDLEPQTHDVDKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNDILYDGDYEEKPLDIVQSIVEEMVNIIVGDMGEGMAISASTEGNTGTVEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQKDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSILQNAGPVFRTNEMFINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTLGQEKPSEQEISEVKHPETINRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRLFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSTKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVRGREGSLTGTKDQAPDEFVGLGLVGGNVDWKQIASIQESIGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVTLVFEKHFPATIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMSVAPEDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIVFRIFDNMKLPEQQTEKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTIPHALLTWRPTSGEAEPPSPSAVSEKPLDAISQKSVDIHDSIQPRSSDNRQQAPLVSVSTVSEEVSKVKSTAKFPEQKLFAALLIKCVVQLELIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYRFLTSQQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQRLLNVCREALSYFLTLTSESHREAWTNLLLLFLTKVLKISDSRFKAHASFYYPLLCEIMQFDLIPELRAVLRRFFLRIGIVFQISQPPEQELGINRQ
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MTVKNFENQVTIKKGPESSTEEASILPDPRKSFRNLVAIKRENEPSAEEEWIPPGPRESPLHMKVESFEDPVTLKRKAEPSAEDEWISTDPGESTLLMEVVEESFEDVASPAQDDSNKKSKTRGNQKEAVAESPDWDYGVTFISPEETYLPKIPLREYQKAQQGRLSKDGGPKRHQCLECGKAFKFNTKLRLHQRTHTGEKPHECPECGRCFSYSANLRTHLRTHTGEKPYRCAQCGRCFSHSWNHKMHQKVHEAKSGQGGQKEAPPHAGPQITTNNSHNRDAV
The following text describes a protein:
Function:
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MHPAFENAGISKGLEVWRIENFEPVPVPVKEYGKFYTGDSYIVLNTKESKSGILSWDVHFWLGLETSQDEAGSAAILTVQLDDRHNGAPVQHREVQDHEGSLFLSYFPGGVRYAAGGVKSGFNEVETNAAGEKRLFQVKGAKNVRVRQVPLTIGSMNKGDCFILDAGYDIYVYVGASAKRVEKIKAISAAGQIRDQDHAGRANVHILDEFASSAEQQEFFDVLGEGSPDAVAEDSESDEAYERSDCKAIALYHVSDASGSLEITPIGERPLKQSMLDSNQDCYILDTGAGSIYVWIGKGATGQERSQAMVKAQEFITAKGYPVHTAVHRVVENGETTDFKQFFASWRDKGISHAQLIKTAMGSGDESDAEAEFDPEVLHTFKKNGGRALGFMPDNGQGAVEIWRVQNYDLEPVEPDAYGTFYAGDSYLVRYEYTVRAGGHGYIVYFWQGKTSSTTEKGASAMHAVRMDDELNGKAILVRVAQGNEPRHFMKLFKGRMVTLLGDYGKQSAEDTKLFRIRGTCSDDVRAEEMAPTAASLASDDVFLLKTAGTVYIWHGVGASDLEKDMAANIAGVVAPDVSAEVVAEESEPEEFWAALGGKDEYDRELDPAGAPFLTPRLFHCRILYNKKLRVEEVPHYEQEDLNVDDVMVLDGGDEIYCWIGNGATEEERSKSIDMARQYIRTDPSERSEETVPIVVLKQGAEPKSFKRLFPTWDDAFWENQMSYEAYRQQALEQNQHAA
The following text describes a protein:
Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Sequence:
MTCKNATLPEILELSPRLEDADPGVRRLALIELADLELPEALPLLVAALRGDPDPGVRGEAARLLEAWEEDAVVDALCAALADPVPAVADAAAQSLGELKEPAAGRRLLPWLGHADAFVRASVLRALRELRLEESAVPALAALGDPQAAVRREAVAVLGWLRHQPALAELARLASADVDPEVRRAATGALGLSREATVLPALCAALADAQWQVREEAATTLGKLGREEAGEPLLKALADDYWQVRLRAARALGRLRHRPAREALEALLGHPIGNLRKEAALALGELADPASAQALRVAEGDGDPEVRKAVRIALAQLRMPA
The following text describes a protein:
Function:
Binds together with bS18 to 16S ribosomal RNA.
Sequence:
MRKYETVFILNPTLDEEGYKANVEKFKGVIENAGGTVDNVDLWGKRKLAYEVKKVSEGYYTLMNFTADTELPKELDRVFRITDTVIRHMIITQE