lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional regulator that binds specific DNA sequences on the promoter regions of target genes.
Subcellular Localization:
Nucleus.
Domain:
The NAC domain includes a DNA binding domain and a dimerization domain.
Sequence:
MGKTQLAPGFRFHPTDVELVRYYLKRKILGKKLLVDAIAEVDIYKFEPPDLPDMSFIRSGDLKWHFFCPREKKYASGVRANRATECGYWKTTGKERPVLCNSEVVGKIKTLVYHFGKSPRGERTDWVMHEYRLDDKVLTQMNVPQDTYVVCVLFKKDGPGPRNGAQYGAPFKEEDWSDEEVRTDVPSTSNPTNLLEPSKETTLALTAPDDSNKDCFGGMISESCVSDFLPATTNTTSELPHPSDAATTPMSTAPLAETVQTPNNDDLYSMLDLFDDDEEFLGFNNNEVRYDPGVSAPVCLEEEGIFNGLPELSSMPRTASYDLVENSELYLELQDLTAPLNPQTGLQDLTAPFNPQTGLQDLTAPFNHQTGLQDHTAPFNPQTGLQDHTAPFNHQTGLQDLTAPFNPQTGLQDLTAPFNPQTGLHDLTSPFNPQTGLQDLTAPLNPQTGNRNDPRSSSFLYNQGHFDFSGGNDDDPYGFSASMRHRPKM
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MAKLPDFEALAIFAKVVELRSFAGAASELAMSKATVSKAVTRLEERLGARLFNRTSRRLALTDAGHKLAERATRLLVDGEAAENEALAQSVAPRGLVRLAVPMTFGIKAVAPLLPEFFETYPEVSVDLHLSDATIDLIGEGFDMAVRIARLPDSSLIARRLFTMPRFTVAAPSYLKRHGRPTHPMHLAEHKCFSYAYLSTPNVWHYTNSAGEQASVRPGGQLRVNNGEAVMPALIAGLGIAELPEFIVGEAISSGEVEVILKDWKQAEGAVHLVTPPGGPRPARVEALADFLAAKLPGTCRRRTRAKAKTV
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MPTAAGKSSAAAAAAAGKEEDYATLRELYRPHIESFDYFLDEGLDKMLLSIRPMEITDPSSNATLRMSLEKGHVLPPMKDGRLEQPLYPQECRQGRISYSGEFKVEAVFQFNDGAPIRQTFNFGHLPIMLMSKLCHLRGADPRKLIYHGEEATEMGGYFISGGLERLIRILILQKRNYPMGMVRGAFIKRGAGYTDKAVVMRCVHHDQSSVTVKLYYLQNGSARLGFWFAGREILLPVGIVLKALIDTSDREIFASLTCCYSDKRERGKGVVSTQLIGERTQIILDEVRALSLFTRTQCLVHIGKYFRSAMEGFEKDDYETVAEAVIKDHILVHLQNDNHAKFNLLIFMLQKLYALVDQTTSPDNPDALQFQEALLPGHLITVFLKDRIQDWLQKSKRLIMEEITKNKSFELNNSLEIRKFLSKYTTSVGRAIETLIKVGRANSQSMLDLPQREGMTIQAERLNFHRYISHFRSVHRGSSFAKMRTTTVRKLLPESWGFLCPVHTPDGEPCGLLNHMTSICRISSCYNSEGAIKDFQKIKDKLLVELVRGGMIPLLPKMEHTGPPEVLHVHLDGCIVGSIASAKIEEVVNYLRRLKLLAHPATPEDLEVGYVPLSLGGAYPGLYLFTSPARFVRPVKNLVSLPDGETRIELIGPFEQAFMEIRCPDGGDGGRKKEFPATHEEIHPTAILSVVANLTPWSDHNQSPRNMYQCQMAKQTMGFCGQALKYRTDVKAFHLQTPQSPIVRTATYKKYHMDEFPSGTNAIVAVLSYTGYDMEDAMILNKSAVDRGMFRGDIFQTECIDLSAKRTENVPEIFAKSPLSRDTDNVIDSDGLPRVGETVVPYEQYYSIYNTLTGAIRPVRLKGTEPAAIDYVALNGTNSKGSLQKVNIRLRRKRNPIIGDKFSSRHGQKGVCSQLWPDIDMPFSANTGMRPDLIINPHAFPSRMTIAMLIESIAAKAGSVHGKFIDATPFASSVKEDGENRCKYDSIVDELGPMLASYGFNHHGTEVLYSGLFGTELQFEIFIGPVYYQRLRHMVSDKFQVRTTGRIDQVTKQPIGGRKHGGGIRFGEMERDALLAHGASYLLHDRLHTCSDYHVADVCSLCGSLLSATVIKSDTQKKSKRHLLGVNTVRPAKNFACQACQTNKGMETVAMPYVFRYLAAELAAMNIKLDLRLSNRREAPPSNESC
The following text describes a protein:
Function:
Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is essential for chloroplast development.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MAVALQFSRLCVRPDTFVRENHLSGSGSLRRRKALSVRCSSGDENAPSPSVVMDSDFDAKVFRKNLTRSDNYNRKGFGHKEETLKLMNREYTSDILETLKTNGYTYSWGDVTVKLAKAYGFCWGVERAVQIAYEARKQFPEERLWITNEIIHNPTVNKRLEDMDVKIIPVEDSKKQFDVVEKDDVVILPAFGAGVDEMYVLNDKKVQIVDTTCPWVTKVWNTVEKHKKGEYTSVIHGKYNHEETIATASFAGKYIIVKNMKEANYVCDYILGGQYDGSSSTKEEFMEKFKYAISKGFDPDNDLVKVGIANQTTMLKGETEEIGRLLETTMMRKYGVENVSGHFISFNTICDATQERQDAIYELVEEKIDLMLVVGGWNSSNTSHLQEISEARGIPSYWIDSEKRIGPGNKIAYKLHYGELVEKENFLPKGPITIGVTSGASTPDKVVEDALVKVFDIKREELLQLA
The following text describes a protein:
Function:
Transcription factor required for both mesoderm and endoderm formation in the embryo; signaling determinants and concentration levels may determine which germ layer is formed. Acts together with beta-catenin to activate genes that are responsible for mesoderm induction including wnt-8, eomes t/bra, siamois, mix1 and sox17. Directly binds to promoter DNA. Patterns the mesoderm along the dorsoventral and posterior axis. Activates siamois gene transcription when alone or in combination with beta-catenin, but inhibits siamois transcription in combination with pou5f1.1/oct-25.
Subcellular Localization:
Nucleus.
Sequence:
MRNCCRERGFSVGRLEPETSFSCASDVKSSPDMDSVSSQDSLYLPNSIGASLEDQNLWTQFHQEGTEMIITKSGRRMFPQCKIRLFGLHPYTKYMLLVDFVPLDNFRYKWNKNQWEAAGKAEPHPPCRTYVHPDSPASGAHWMKDPICFQKLKLTNNTLDQQGHIILHSMHRYKPRFHVVQSDDMYNSPWGLVQVFSFPETEFTAVTAYQNEKITKLKINHNPFAKGFREQERSHKRDDVLKTLQQSPSKSQKRKKWEDSPEADISDFPKATRIKEESIMDPAGVYQNWVSDHEANQGLTPHSPESEGVNQEQQVPTSSSNFYIKSQYRRSSQHLSSPYDLGEPSSRRLTPDVATVPDSDPDSLAVLHVIPTQNSAQERTCSMNFSMETPMKQPLRGAIYSPYGTEQWMVPAQGPYQPVSYTAYPTDLSAQGAVAHPHSGMSDWSQYSLFPYSCW
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MALSIEQLMTFTTIVKAGSLGRAAALLNMTQPALSRAIKRLEQQLGAELFERHSKGMQLTDIGRAFLPHATSLHVEAKQALEEIQALRGAAKGTVRVGAVASIASSILPPAIERTLTKWPGLHFEVFEGVWDLLAASLSKHEIDLALGAEAPDTDEIVAIRDCCWEDTSHVIVASGHPLRRRRKLTLADTLHEKWTIPPPGTGPHQHVERVFAEQGLGMPDVIVRTRSITVLKSLVVDSGFLSWMAEPMFEPERRAGLIAPLSIAGVDGRRKLVAFRRRRGLLAVPAVKLLDELRRLTSTGSRKR
The following text describes a protein:
Function:
Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
Does not contain ARM repeats, but instead Ser charged repeats. May have specificity for cargos distinct from that of other importin alpha subunits.
Sequence:
MGDEFRPSHEERSKMYKSNVRDQNEMRRKRREDEVQIRKNRRDEKFERNRQITVQRSLSHEETSELLKSVADGLQSMQETTIHEALTVLHENLNNTVWTIHVLVKVQILHKLSDVYCNRVISQTTRLLISRTLLKISGIDEVKYERYSSDDRCIQSLVFNISTYGSSEDILCDTFQSIACFIIRSITYRNLALDCAIVSELIDASTINMSIILHRSLMWLVFLFCEKLDRCSPHVDEIAPLLEIISNGIQSTDAMVQTDAASSCASLAEWPPIYHYMSDLKLCSKLVANLRNDKGNARPKVKAGINSIIQATGYFTEEMIDAGLLEVLKGFVNVSYMSQEVCFIISNICVEGEQTIDKLISSGVLREVARVMEASEYRSRREAAFVICHCCASANQKHLEYVVELGMLSAFTDLLTCMDVSLVSYILDAIYLLLQFGEMRLLPDNSNPVAIKLEEIGCREKLEFLCESQSVDIHARAYTIIDRFYVDDDAPLNDDPFAGYQRNNIDDTIEKMIREPIMDQPFSF
The following text describes a protein:
Function:
Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7).
Sequence:
MLDGASTAPSEAERCIIAMMLMQIALDTHDEVTDDGGDLRARQLVVLAGDLYSGLYYELLARSGETALIRSFAEAVRDINEQKVRLYEKKVERIESLFAAVGTIESALLVKLADRMAAPQWGQFAYSYLLMRRLLLEQEAFIRTGASVLFEQMAQIAFPRAKTLTKEQKRHLLRFCRRYIDGCREALFAAKLPVNGLLQLRVAELSGGFQAIAKKTVEEG
The following text describes a protein:
Function:
This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process; Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane.
Miscellaneous:
MISCELLANEOUS: HERV-FRD subgenomic RNA has been observed; MISCELLANEOUS: Ortholog in old-world and new-world monkeys, but not in prosimians; MISCELLANEOUS: The human genome contains a high percentage of proviral-like elements, also called endogenous retroviruses (ERVs) that are the genomic traces of ancient infections of the germline by exogenous retroviruses. Although most of these elements are defective, some have conserved a functional envelope (env) gene, most probably diverted by the host for its benefit.
Subcellular Localization:
Virion; [Surface protein]: Cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM; [Transmembrane protein]: Cell membrane; Single-pass membrane protein.
Domain:
Contains the CKS-17 immunosuppressive domain present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo (By similarity).
Sequence:
MGLLLLVLILTPSLAAYRHPDFPLLEKAQQLLQSTGSPYSTNCWLCTSSSTETPGTAYPASPREWTSIEAELHISYRWDPNLKGLMRPANSLLSTVKQDFPDIRQKPPIFGPIFTNINLMGIAPICVMAKRKNGTNVGTLPSTVCNVTFTVDSNQQTYQTYTHNQFRHQPRFPKPPNITFPQGTLLDKSSRFCQGRPSSCSTRNFWFRPADYNQCLQISNLSSTAEWVLLDQTRNSLFWENKTKGANQSQTPCVQVLAGMTIATSYLGISAVSEFFGTSLTPLFHFHISTCLKTQGAFYICGQSIHQCLPSNWTGTCTIGYVTPDIFIAPGNLSLPIPIYGNSPLPRVRRAIHFIPLLAGLGILAGTGTGIAGITKASLTYSQLSKEIANNIDTMAKALTTMQEQIDSLAAVVLQNRRGLDMLTAAQGGICLALDEKCCFWVNQSGKVQDNIRQLLNQASSLRERATQGWLNWEGTWKWFSWVLPLTGPLVSLLLLLLFGPCLLNLITQFVSSRLQAIKLQTNLSAGRHPRNIQESPF
The following text describes a protein:
Function:
Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH. Shows a small preference for NADPH over NADP(+). Represses translation and promotes degradation of target mRNA molecules. Plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos.
Subcellular Localization:
Cytoplasm.
Sequence:
MFHSPRRLCSALLQRDAPGLRRLPAPGLRRPLSPPAAVPRPASPRLLAAASGAARSCSRTGECTPVPGGERHGSQRAAVSQHCATVLQPGEQIETPSPKKNFFFSALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLVNSANIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKRFASSSLNLNSAYKLLSADGQSEPPYTTWKIRTSGECRHTLDYIWYSKHALNVKSALDLLTEEQIGPNRLPSFNYPSDHLSLVCDFSFTEEPDGLS
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MTYSYCVNHMEKLQDLSQSELEELLDNPERVESMALESDEIQSIQLEREMALASNRSLAEQNLDIRPRLETQKELLVARYSKLETFRETYRQHCSQRDGMVGKVSPEAMLSRLQTGSSRTEMESEALADEFLEGSLSLDSFLDRFLSLRLLAHQRRVRIEKLQEILRQKNQANSFEMKPSLDISQSGTTTPWNQQSTITTTAQQQEPNSPAQSHPAGSDGLPYSQYPVPPTHPPPVVSAAGPIPNNSTSGFAPYAGAGSPFTPTGSYPGPRAGSPFTPTGSYPGPRAAFGPPNAVTCPYPAQSSFPAPHPGSAFGQYSPNNPHSAPATYPGSYIYGGYCYPSGPPYFSSQSSPGKPVNRPGYRVPHSCSSLYL
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Sequence:
MLSLRRALLVPRLGRALHTMPAYSGLGSQAAPTQINKFLSAETVKSAWFEHQHEMLERVNEGLASSEELEGLDLQSLALETCNRSEDALHHFASGAFANDFFFKGVASTVKPGEVSEPIDAYHGLYVSPRDPDYQTVMPALATGETPAWGNHPGTDDALYDLILTSFGTVEAFREHLLTKAESIFGNGYTWLVLSKHSGRLHLVNTYNNGFIQKKGTNSAELAAEAAAKRAVEADEAKALAELQAEAQNKKLNALEEKLLKNKIYKMEVAKQMRQAQPKILHDLKPLLNVNVWQHMWLNDYGAFGKRKYLDNFWEKIDWNVVKGRLQDHFEKQTDLSKSELFGPYV
The following text describes a protein:
Function:
Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine.
Subcellular Localization:
Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, cytosol.
Sequence:
MMGVEVQTPGGPKLAHACSIGLSWQQSALPFLFRGRGLFTSSFRAANHRPSLIPIGRFALSPPISFWARGGIGERCFSPRAGLRGGVPCDWLRVGAKARGAERRPVLPAMAGCRRLSGAGLREVLGEAQGVLFDCDGVLWAGERAVPGAPELLERLSRSGKAALFVSNNSRRSVAELERRFSRLGFRGVRGEQVFSSALCSALYLRQRLLGEGGAGDSASSSSASSPPLPGPGTVFALGGEGLRGELRDAGLRLAGQEAEEGGEALPVRAVLVGYDDQFTFAKLSQACAYLRDPHCLLVATDPDPWHPLSNGQRTPGTGSLTAAVETASGRKATVIGKPNTYMFECIVERFGVDPSRMLMVGDRLETDILFGKNCGLETVLTLTGVSHLEEAQAYMASDSPAAKDLVPHYYVDSIADLIPGLDE
The following text describes a protein:
Function:
Transcription repressor that binds DNA in a sequence-specific manner, 5'-GCCT-3', to regulate the expression of PGR. Acts as a modulatory component for the glucose-triggered developmental leaf growth process.
Subcellular Localization:
Nucleus.
Sequence:
MAPLESPATASSSEVESSSEEIFKSSSEESKPKDPVTVPSSKTLKSPSAAVNSKTDSSDDSEKQSFVLTRRKKKEGAAESPAVKSGKKRAGEGSTSRDMHVKRVKKEDDNKKANPQRVWSEEDEISLLQAVIDFKAETGTSPWDHKNAFFDIAKKSISFDVSHVQFFDKIRRLKNKYFVNRKNKSGESNHDKKCLGLAVLIWGSDGMNVESPVKKDESILVKGKANSKEKKVEKPLVIEDEQVILGADSEWFEESFLVPVIANLGLDEYSVKKKWSKVSLETKKKIQEKMKVVDAKKCELLLAEMDVLKDVTSVLAQTN
The following text describes a protein:
Function:
Catalyzes the 3-beta-hydroxylation of 2S-flavanones to 2R,3R-dihydroflavonols which are intermediates in the biosynthesis of flavonols, anthocyanidins, catechins and proanthocyanidins in plants.
Sequence:
MTFSLPHHPTILAPEFVRHHDDRPKVPYNQFSDEIPIISLSGIDDNGERRAMIRHSIVEACEEWGIFQVVDHGVDSEIVSDMTRLAGEFFGLPTEEKLRFDMSGGKRGGFNVSSHLKGEIVKDWRELVTFFTYPIEKRDYSFWPDKPEGWAAKTAEYSEKLMGLACKLLEVLSEAMGLEEEALKKACVDFDQKIVVNFYPKCPEPDLTLGLKRHTDPGTITLLLQDQVGGLQVTKDGGRTWITVQPVQGAFVVNLGDHGHYVSNGRFKSGDHQAVVNSKSSRISIATFQYPSQESIVYPLKIRDGEKPILEKPITFSEMYHMKMKNDIEFARLKKQTQKQAQDFVA
The following text describes a protein:
Function:
Has a role regulating cGMP transport in Malpighian tubule principal cells.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MHGPVSRSSSSSNMTDVSSPAGGAASPVEMTTSSSSAATTSASSSKPLTNGANKTTISTVAGGVAPGAVPGPGSGAIPASSSSGNQVKLEHHHRQSNNNRPAATNRSSETKLRSPAGESDGASRLMTPAGSSSSPSQSPSQTQASIQTQTSQQDRLAKASTTASQQDVDEVARLFEEKPEAFEKWLTERAPPEALSRLQEFIENRKPHKRPSVTSDLFQQWMAASPTVQQKSPRSLSNSSASSLPECRRHLMDLDEGELFMELIRDVANELDIDVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVAKLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQQATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDSTQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYTTSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEKVEMGLTWIDHDTIDKPVEEFAACADEEIKDIEFTVTTLNCNQQSQHGSEDSHTPEHQRSGSRLSMKKTGALGKAVRSKLSKTLYNSMDGSKPKTSLKLLESHVSEDMDDKSPTSPSQPQASGSMGRMSASSSTSSTGGQMVDKSKKRSKLCALL
The following text describes a protein:
Function:
Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPCRRRPFHLPGLRTADAMTHVRTLDDRAVRLFIALAAFFCVNAALAEFIGVKIFALEDTLGIAPLNWNLFGQTGSLSFTAGTLLWPVVFIMTDTINEFFGSRGVRFISWVAVGLIGYGFVFAFAAIALAPAGWWVTAAQSQGVPDYQAAFAAVFGQGLWTIGGSLVAFLFGQLIDVSVFHRIRRATGEKHVWLRATGSTAVSQLVDSFVVIYIAFVLGPQHWSIDQFLAVSTLNYLYKMGFAIALIPLLYLARRAIGAYLGAERAEQLREEAAAD
The following text describes a protein:
Function:
May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MALPTLPSNWHSRSRVLEQQIVRQREQEARLRHQWDQTNQYFKQSNVCSSKQAQWSSRQSYQKSMNAFHQEKQKEEKKKTLEYRREQLRKLLQEERDLLEEELKELRCNKEHNVSDMRQRTEELKSAREERQKQLAEELLYEQWKKNNVKLREVESSLFKKHVVDAWGEQITARNQEKEEEDMEKKRLENEYELARREAIERMKRDKEKRQQQEEELARVLKWQMEELKLKDLEAKKLKKEQEDLLRQQWEIEELEEERRKMEQCRKKTELSHFLSRQYNAQMKRRAQQVQEELEMDKKILSALISKEDEDQHLQSARREQAIADVAWMKHVIEEQLHLERQREAELDTLFREEAKQVWAKRETEWERERNARNRLMKEVLAGRQMQIQERIERNQLAQAESVMNRERLLRQLEEARQFTSREKKQEEEQKTARRTELEAQIAEQLLKGKEAIVQQEEEEKEFKLAEDLENDLLQQEAEIMTQRGYQKKTYSRPRTAWS
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MDLKEVKRSEEAEEMKSCSYCHTTKTPLWRSGPSGPKSLCNACGIKYNKKRRQILGVEKKRRIVCKEEKSREIGKLMGFGGKLREEEQAAILLMALSCGSVGKLLF
The following text describes a protein:
Function:
Protease involved in the processing of a variety of prenylated proteins containing the C-terminal CAAX motif, where C is a cysteine modified with an isoprenoid lipid, A is an aliphatic amino acid and X is any C-terminal amino acid. Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins, leaving the prenylated cysteine as the new C-terminus. Is able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAALGGDGLRLLSVSRPERQPESAALSSPGPGLCCWVSVFSCFSLACSYVGSLYVWKSELPRDHPAVIKRRFTSVLVVSSLSPLCVLLWRELTGIQPGTSLLTLMGFRLEGIFPAALLPLLLTMILFLGPLMQLCMDCPCDLTDGLKVVLAPRSWARRLTDMRWLRNQVIAPLTEELVFRACMLPMLAPCTGLGPAVFTCPLFFGVAHFHHIIEQLRFRQSSVGSIFLSAGHLIGPVLCHSFCNYMGFPAVCAALEHPQKWPLLAGYALGVGLFLLLLQPLTDPKLYGSLPLCMLLERTGASETLLCS
The following text describes a protein:
Function:
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
Subcellular Localization:
Cytoplasm. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes.
Sequence:
MNRAFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGLQKRIQDLETENMELKNKVQDLENQLRITQVSAPPAGSMTPKSPSTDIFDMIPFSPISHQSSMPTRNGTQPPPVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPLDSRC
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization.
Sequence:
MSVDPKQSKIADVFERCDVLESFPFHDDQSEIEEQSPSIGYDAYDKSLNYTDRGAYETQWSEETIGMEKMEEVLKQGDSFINMVYTYRSCSKALPTVKTAEQVNKTQIYEGNFEVLEPEIKKLKDFMYFQKDTIKLFCDHIKKLASTYDKKKETISASESFINYLVRILDLLAILDALKNMKACLNNDFSFFKRATGFLRKQMSGTEDQTQENHTLYLFLANQNSITSSLKLELHNIDKFDDILPMIVNQCADYLEQEKYILPSEKHCLLRVMPFVLFLIDENDSKHNINKNKNLNISRYAKIFKKNPVVPLYGDMQITLESLVKRSPHFDEKAWGTSTLDSKSALDYEIIHVLDQTRSLYNEYMARFANMVNEIRAAKARGPKEPLPLAESDIQAITLMGLRILSDWTSRVLQQSAWKYSKPNNDPTISATFDYERVVKFNYTKEERTALVQLIAMIKSLASLMMKSETLLQPILRKTIHQELQEFVQINLKETIKSFVKNNPKKKDNIKLEMSQLKNISVDWFSGFEPAEAVPNKKSKEVEEKVQIPARAVPPSPTQLELILTLVSSLMDKKKDFSSDQYRDFEAFSSKAFFYRYLLSLSSSIISITDLADLWYREFYLELNNRVQFPIETSLPWILTDHILESDDPSLIEHLFYPLGLYNDTAQRALLSLNQRFLYDEIEAELNLCFDQLLYKLSGKVYTHFKTQASSILLDKPYKTQLELAHFNGKLHTPKSRFDVLLRQKHITLLGRSIDLCGLLAQRQNNTIRQNLDYAISRFEACDLTSIVELETQIANIKLTHKLLSEYFDIDPFESIFNEINESTSLVSYHGRIVLHIIFELVADFAPNYTFNSITQRFIKAPYTFTEELKRDALPKTNPVFLFGNKYLNAAYANSIELYKNFIGVPHIQSILRIVGKKNLPLIVAEVLRNIEIKITNVLSPYVSELLQGMPASTKLPIYDYGTEGGYGYFQLKLKDIYIYPDLRPEVLQTFRELGNSLVFMNLLDQVITQTDSYNFAKAAPFLGITPETWKDLEPSTEDPTLQSPLYSQLQKLAQLLESRPEVAKSSQSLNDMVANAWRADKFYRPSEQNFSLFKSVLQRFSSILNIVRHDWSGAPPDNGVICVDSSTEFYRLWSALQFVICWPLSNENDKSFHELFGDGLMWAGCSLIHFLGQQYRFELFDFCYHILNVEEAAAVRSDKPALKNFFKNAQIIKDINNQIFSILNTYCPPPPPSNMILSPPATEQAEQFIVTTTVEEQSIQQQQQQQQQQQLQQSTSNSGSSLSLSAAGAPPPPPPPSTNGLPPPPPMAEYEMSSSIDDFAPPPPPPFGMPPPPPM
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MASAVLSASRVSRPLGRALPGLRRPMSSGAHGEEGSARMWKALTYFVALPGVGVSMLNVFLKSRHEEHERPPFVAYPHLRIRTKPFPWGDGNHTLFHNPHVNPLPTGYEDE
The following text describes a protein:
Function:
Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.
Sequence:
MMILVTGGARSGKSRHAEALIGDSSQVLYIATSQILDDEMAARIEHHRQGRPEHWRTVERWQHLDELIHADINPNEVVLLECVTTMVTNLLFDYGGDKDPDEWDYQAMEQAINAEIQSLIAACQRCPAKVVLVTNEVGMGIVPESRLARHFRDIAGRVNQQLAAAANEVWLVVSGIGVKIK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MGGHQVLQLPKDRTNGLLTFKDVAIEFSKEEWECLDSAQRTLYRDVMLEIYSILVSVGLSISKPELLTYLEQNEEPYIAKGIEPVLSCFHNKELFKIESKQESAQREGPGQFGSSRLGKLHVNLPNDMDCNVDQHKTVYENPVGRESHHWLGISEYCHRYQEDNKGLTTDFALHNNHNSQFTEISYQGNDSWNIYKQDVTPSEGQISNCSLENCYNNDRCRGVSGQCTQSPLYQQDYSQEKLSTSSQQYKIANECSNCSQCTEIKARREFNRQRYDKYSKVSVESPSIDRDKVNDIQRKPCLFMGSDKSFNFYLNMTQNDSSHTREKPQKYKEYRLEITSPSKLVGHPRSFVQQKYRKSGKCSRSSSDLSRLKMLQPGGTPCKSTECGKSFSQFSGYRENGTIHTGEKPYKCKICKRSFTTGSYLQAHQRIHTGEKPYKCKECGKSFTHGYSLRIHHRFHTGEKPYKCKDCGRSFAEGSSLKSHHRIHTGEKPYKCKECGKSFAKQSNFETHSRIHTGDRPYKCTDCGKSFTRSFCLRKHHKTHTGEKAYKCEECGKAFTQRSTLKTHYRIHTGEKPYKCNECGKSFTEGSTLKTHLKIHTGEKPYKCKECGKSFAEASTLKTHHRIHTGEKPYKCTDCGKSFTQSSHLQSHCRIHTGEKPYKCKECGKSFAKDSSLQKHHRIHS
The following text describes a protein:
Function:
May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MEFRGSGATAVEQHLLQSETPGKNGLQATSSDQVGRTLRWFTTVVLNAAFLGMGVSAAVLGPTFPDLARNVNRNISSLSEIFVGRALGYLGGSVVGGVLFDCMNHFLLLGLSHLLTAAGLYLTPFCKTAALLTAMMSITGVSFGVLDTGGNVLILDLWGDKGAPHIQALHFSFALGAFLAPLLAKLAWGTTASAQNHTEPQLDRSALNRSFEAASDSVLAVPDDMNLLWAYASIGTYVLVLSVFLFAPFFKKRSKQKKSAASAQGARRAKYHRALLCLLFLFFFFYVGAEVTYGSYVFSFATTHVGMEESEAAGLNSIFWGTFAACRGLAIFFATLLQPGTMMVLCNIGSLASSFFLVLFDKSPLCLWIASSVYGASMAATFPSGISWIEQYTTLTGKSAAFILVGAALGLMATPALSGILQGHYPDLPVILYMCLGSAVLTTVLFPVMYKVATLPLDRKQEKSINSEGQKILLSSSRLIKEAK