lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate.
Miscellaneous:
MISCELLANEOUS: Restores staphylococcal growth after ltaS depletion.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein; [Processed glycerol phosphate lipoteichoic acid synthase 2]: Secreted. Note=The secretion into the extracellular medium is dependent on SecA and Ffh.
Sequence:
MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKILLFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVIMQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASSILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSSDVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKLAHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKSKNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESMPLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQFFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIHAAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFISPKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKKVNPSDYDYTKHDEDSSETSKDNEDK
The following text describes a protein:
Function:
Flagellar protein involved in flagellum axoneme organization and function.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MSIQTRSAVGYSGGQVTWTGPDECAWTCGNAVVLHTLGSKAQRVLKGTGFGISCFAVNKRHGLLAIAEKGLKPMVTVYSTKTLQPLAKLLPGDVREEGAGGGADKPSGSGAVSGKQQSSGPSVVLGVTCLAFSNDGERLAVCGDEPDCSVIVYGWRKAEVLGRCRMPAAASSASSTSPASSVSFHPLDASVLATSGPGGACAVWFLEPLWEKAVFRPLQLAAGALPAGAEVTCHAWGPGGLYVGTSTGGLVLLDTATMAPLQLHAAAGGAAGEVAGGASGGASSPTPGASSGGAAGGSVVAVVPDAVTSGAAVTALTLNRDLVAVAGADGSVRVFVSVPAAAAAITPEPLALSHEVWLGRAGPARGVAVASAECGGADHATLLLGCPDGTMYRAPLAPKQGGGPTHSVLVVDCHVGRLAGVVPHPGGGAFLTTGSDGSVRVWSTTDGALLGRKQLSSAQTALAAAAPGASLAAVGSETGVVRVLVLPPASTAASAAASDAPLPALRVLFRQRLHSAPVDVLVFSPANDLLLSAGRDGIAWLCSVDARGGRVRPLGCLSLPPGERVLSATWPRSDGGSGAASGHAQAGPVSTTSAEGDEPSCLLSLAGGGLMCLTASAELHSGNWRNPYPDMVLLVTIKLLRLEVAMLAVAAVPGDRYGDAYGLGADKQLHKLVLPAEAAAWAGLRARPLRSAQHVPAHARASGGVAVAPGGHLLASGAADGTVALRNMSLITLAAQQGGDGAGAGLHDITAGGVVTVSFDATGRYLASAGADGALFVYELSKRAAVANRLATLRSRIADLLAANEAAPELERLTRNDMIVDVGLVEELQRETENRVAAVQAAVKKEHLRTELLAERVRRMVWDSMAVKGAVISGLRAPPGQHERVLKQVTMLRRVELAEQAALGVIPYGLIDFDVYCNTRKALQVQLLKQKMRDVQAGFNTDFNKVAAAKKADCDRIADLNARLDDTLKDLRKLGAGPPAGLLDERFSLSAQQDTRDNIAATVLMVREEEVGAERYVSPAERAKQEAARKADEDAAKRSAKDNAGERALRQMMGGTLAARGGGHDESNPFSLPKPAWLVALGVEPDAVNPKLITEEQNRELKEWQAKEKSLQEERAKRITVLEMELRTAKAAVEELTSEAVERGLLARLGAAKEAHGRAASELSERRAALAELESRQAQLGADERLMDRNFKKEFAEADIHLNRLLQLYRARKPEQLASMPGGGAIGAAGGHQSGVEASSGSFSRVPGGAPGLHRQASLAHSPSGAAAAGGEAAGAATAAGGAGSSGGAAPCGAAGNPSTGPPANITPTYTHALPLPHAAVAATTLNPFPDAPPGASGHDRPGSSALHPSHSHASVHGNHAHHHLSAAAAAAGHSDPLHNLSGLKPEGLDAALWDRFVAYRAERLAAEAGARAAAGDLVLARRDLPELESREAALGSEMEVLMGSITALRSERKVAAYDNEVQLRLLAGQVEAMPPRPASADMSDARLLGRGVVESLNSVVLGKGTKKVELLTAMKDFKRGIYAAQWEAQAADMRLDDLRAKIRDLQLLHVTRDMQTVLKDGEDRSSALEAANLEALMKQRERLHAKALEDKRRRLRKLAADVSSRSAQNQEVAVHLVTLGKVLEEQQRLQAGMQSANDQATRRMRSLVTHKKLKEIALAQQNELGELRQQLEKLRLRTYPTFIESGAVAGMPSPPRRLPPDIKLLAGSPSSSSVAGRT
The following text describes a protein:
Function:
Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements.
Subcellular Localization:
Nucleus. Chromosome. Note=In axial/lateral elements of the tripartite segments of synaptonemal complexes.
Sequence:
MPVRPDLQQLEKCIDDALRKNDFKPLLALLQIDICEDVKIKCSKQFLRKLDDLICRELNKKDIQTVSSILISIGRCSKNIFILGQAGLQTMIKQGLVQKMVSWFENSKEIILNQQQSKDEAVMNMIEDLFDLLMVIYDISDEGKNQVLESFIPQICALVIDSRVNFCIQQEALKKMNLMLDRIPQDANKILSNQEMLTLMSNMGERILDVGDYELQVGIVEALCRMTTEKRRQELAYEWFSMDFIANAFKEIKDCEFETDCRIFLNLVNGILGDKRRVYTFPCLSAFLGKYELQIPSDEKLEEFWIDFNLGSHTLSFYIAGDEEDHQWEAVTVPEEKVQMYNIEVRESKKLLTLTLKNIVKISKKEGKELLFYFDESLEITNVTKKVFGGNKYKEFTRKQGISVAKTSIHVLFDASGSQILVPESQPSPVKENLIHLKEKSDIQKKLVNPLELGNSSSQDEITTPSRKKMSEASMIVPDTDRYTVRSPILLINTSTPRRSREPLQAINSVEKAVSKTSESGMDYAASPKSRQSDGRKRWNNRANHNKTTAVIQNKQYEDNESPDQNFNEIEDTLSNVSSAVGKVDKPVLPGVLDISKNTTHSRWACWTPVTTIKLCNNQRSRALPGDTCTQDTGVNKKCTKQKSVSDDDSEETQKGKYSKDVIKCNKSDEAEFCERNIQEQNHPKYSQKKNTANAKKSDWHIESETTYKSVLLNKTTEESLIYKKTCVLSKDVNTTICDKSPSRKSKRNHTKSRKELMSELTSCELEEIPVRENSKGKRFTGASESLINQISRRYNPSDSMMSTRKLKEPQDGSGFSKKPDLQFNKVQRKSYRKLKATVVNVTSECPLDDVYNFSLNGADEPVIKLGIQEFQATTREASMDNSLKLVKNHDEHDPFLKTKDKRMLSYEKKTLLSDTETECGCDDSKTDISWLKEPKTKRLMDYSRNKNTTKYKSRKSRSSMEKGQPRPTMVLNKNSMKNDYEVVVDGRTRLPRRATKTKKNYKDLSTSESESESEKECSYLFKDKLPTKEETIHSRAQTKKLPEKQQKVFNSEALKGQPSEEQKNSSRLREGREDSLCLSSASVSRSSSSVEVMRCTEKITERDFTQDYDYITKSLSPYPKAPSPEFLNGNNSVVGRGQSPRISETSAMCVRKSYSPASGPPFSPRHTPTKNNSVVNMKKANSVINNQRTQHCNSYSDVSSNSSEKLYMEPESPESCDNHMQNKREGNHAASPLSLSSEKIEKMWFDMPSENTHVSGPSQRGSKRRMYLEDDELSNSNEAEVEEAEEREHLLSKKRCQWENSDQHTFKTSLSTPDFSVPKDWQQELQGAGMFYDNISSDYKRKTDSQHKIMDDFTTKTLKLTQQHLMAMTSQAQGRRDENVEKFQVTLLDELEKVEKDSQTLRDLEKELVDIEEKLVQKMRAYHRCERERFRVLKTSLDKSFLVYNSVYEESVFTSEMCLMKANMKMLQDKLLKEMHEEEVLNIRRGLQSLFKAHEGNDA
The following text describes a protein:
Function:
Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation (By similarity). Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (By similarity). Within the RQC complex, Clbn/NEMF specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Following binding to stalled 60S ribosomal subunits, Clbn/NEMF mediates CAT tailing by recruiting alanine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal alanine extensions (CAT tails) (By similarity). On mitochondrial surface, plays a role in mitochondrial-stress induced translational termination impairment and protein carboxyl terminal extension (MISTERMINATE). Plays a role in regulating nuclear transport possibly through directly binding to both emb and cargo proteins. Plays a role in the regulation of G1-to-S cell cycle transition. Regulates S phase checkpoint by antagonizing E2F1 activity. Together with hid and tefu/ATM, plays a role in DNA damage-induced apoptosis through both p53-dependent and -independent activity. Plays an essential role in the regulation of mitochondrial structure and redox state in enterocytes which is essential for the control of intestinal stem cells proliferation and intestinal homeostasis.
Subcellular Localization:
Nucleus. Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The N-terminal domain contains a nuclear export signal. The C-terminal domain may interact with cargo proteins.
Sequence:
MKTRFNTFDIICGVAELQKLVGWRVNQIYDVDNKTYLFRMQGTGAVEKVTLLIESGTRFHTTRFEWPKNMAPSGFSMKLRKHLKNKRLEKVQQMGSDRIVDFQFGTGDAAYHVILELYDRGNVILTDYELTTLYILRPHTEGENLRFAMREKYPVERAKQPTKELELEALVKLLENARNGDYLRQILTPNLDCGPAVIEHVLLSHGLDNHVIKKETTEETPEAEDKPEKGGKKQRKKQQNTKLEQKPFDMVNDLPILQQAVKDAQELIAEGNSGKSKGYIIQVKEEKPTENGTVEFFFRNIEFHPYLFIQFKNFEKATFESFMEAVDEFYSTQESQKIDMKTLQQEREALKKLSNVKNDHAKRLEELTKVQDVDRKKAELITSNQSLVDNAIRAVQSAIASQLSWPDIHELVKEAQANGDAVASSIKQLKLETNHISLMLSDPYDNDEDDDLKDPEVTVVDVDLALSAWANARRYYDMKRSAAQKEKKTVDASQKALKSAERKTQQTLKEVRTISNIVKARKVFWFEKFYWFISSENYLVIGGRDAQQNELIVKRYMRPKDIYVHAEIQGASSVIIQNPTGEEIPPKTLLEAGSMAISYSVAWDAKVVTNSYWVTSDQVSKTAPTGEYLATGSFMIRGKKNFLPSCHLTMGLSLLFKLEDSFIERHLGERKVRSLEDDQIDPNVKENEVEHDLLSDNEDADSNINLSEPSSNTEITAFPNTEVKIEHDTGRIIVRSDSVNPEIEETKESEVVLDKILKKTDDEETTIILAGPSRKKQVSAKKTKEDKARAKQEAAKQEVPPVSSEPKNPSQVKRGQKGKLKKMKQKYKDQDDEEREIRMMILKSSGKEKPQASADKVVEKSESTKEYVKPEKSAAPKNPVELDDADEVPVGGDVDVLNSLTGQPHEGDELLFAIPVVAPYQALQNYKFKVKLTPGTGKRGKAAKLALNIFAKEKSCSAREKDLLKSIKEESLARNIPGKVKLSAPQLQKYHK
The following text describes a protein:
Function:
Insulator DNA-binding protein. Recruits Cp190 and cooperatively binds to chromatin promoter regions to exert transcriptional regulator and chromatin insulator functions. Chromatin insulators are regulatory elements that establish independent domains of transcriptional activity within eukaryotic genomes. Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops to form topologically associating domains (TADs). Chromatin binding sites often cluster with those of other insulator DNA-binding proteins such as pita, CTCF and BEAF-32, but not Su(Hw).
Subcellular Localization:
Nucleus. Chromosome. Note=On polytene chromosomes of third-instar larvae colocalizes with Cp190.
Sequence:
MNCCICQFSVRVPKDIHTDTVGHPPVLISELVLQCTRGTNYVLTEESSTICKKCCEKLARYHKSIQIARKLRGEILELIHSPYMSKDHKQTSYKEDDLDRETTISKFDGNIEEAQQQDEEEQELESVGTTVTLVGPAGIVEEVAEEEHTFIIKQSEEEDEFHSVDLELDIDNEIIINEEEAHEVEEVAHEIEEVAHEIEEEDLLPHDKQEAQEEDFFKEDTMSDFDEHLDGAIEYIISDGEDQEQDNESSGEYTVNIQCPSCPEKFSSRRAYNVHTKREHFPGYVCDQCGKTLQSYSGFIGHLQNHEPVKQFACPVCPERFSRKFRLKHHMAWHSGETPYQCDVCSKRFVHKVALYKHKMIHDSETKRLECQVCGFKTRTKAHLERHMRSHTGDKPFACPVCNKRFSQMYNMKAHLREHESPGTNRHRRFHCSKCTHTFINEQNYDAHVQRDDCTPV
The following text describes a protein:
Function:
Forms conjugate with SPH1 and HBT1. Involved in morphogenesis.
Sequence:
MIEVVVNDRLGKKVRVKCLAEDSVGDFKKVLSLQIGTQPNKIVLQKGGSVLKDHISLEDYEVHDQTNLELYYL
The following text describes a protein:
Function:
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSSTKRSSMLPPPPKPPISFSNNIIIADHASIIGTNLITIRGHTVLHPRTKLNSTYAPIAIGIQCVIGERSSIGMLSAPTEEQAQGVVLDTGVVVETGAIVEAKFVGQGSLIEINAKVGKGAVIGKVRISQGWIFI
The following text describes a protein:
Function:
Carbamoyltransferase that mediates 3'-carbamoylation of the noviosyl ring to produce novobiocin, the final step in the novobiocin biosynthesis pathway. Novobiocincin is an aminocoumarin family antibiotic that targets bacterial DNA gyrases.
Sequence:
MLILGLNGNVSAAGADVVPNLNELYMHDAAATLVRDGVLVAAVEEERLNRIKKTTKFPSNAIRECLAAAGAKPADVDAIAYYFPEDFFDDIFQQLYTEHPSVPTRYSREMILERLRVDLGWAAPPDILHYVPHHLAHAMSTYYRSGMREALVVVMDGAGERNCTTIYRSDGAELFEIASYPVPKSLGMFYLYGTRHLGYGFGDEYKVMGLAPYGDPSTYRDVFSTLYSLGPNGTYELIPRGGVVFRMTTILREHGLQPRRRGEPFTQAHMDFAASVQETTEQIAMHVIGYWARSTGLRNLAFGGGVAHNSTLNGRILTSGLFDEVFVHPASHDAGSSEGAALVVARERGERVWPLPRLTNASLGPDLGDVDSLERTLKSWSPLVDVERPDDIVEATAHLLAAGEAIGWAHGRSEFGPRALGNRSILADARPKENQTRINAMVKKRESFRPFAPVVTAEAAGDYFDLPETVGHHDFMSFVVQVRADRRELLGAVTHVDGSARVQVVTEETNPRFHRLVTRFGELTGTPVLLNTSFNNHAEPIVQSVDDVLTSYLTTSLDVLVIEDFVVRRRTELPLALEDFTIGFRPVTRLVRRLADVSAGRPGAPEVSHEIYLDHTSGPRATISAAMYELLTHADGVTPLGSLGIELTGELLTELYDLWQGRFVTVAPVGDGAGSAP
The following text describes a protein:
Function:
Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development. Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (By similarity). Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development (By similarity). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2. Also plays an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair. Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination (By similarity). Contributes to non-canonical Wnt signaling during epidermal differentiation (By similarity). Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSGRSKRESRGSTRGKRESESRGSSGRVKRERDREREPEAASSRGSPVRVKREFEPASAREAPASVVPFVRVKREREVDEDSEPEREVRAKNGRVDSEDRRSRHCPYLDTINRSVLDFDFEKLCSISPSHVNAYACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLPDNYEIIDSSLEDITYVLKPTFTKQQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKKTIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILAKFNGITEKEYKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHENTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDNDETNQQGA
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Sequence:
MITDVQLAIFSNVLGVFLFLLVVAYHYINANTGKSSPKAK
The following text describes a protein:
Function:
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MRTSSMMENQVSLSSIQRAVWDGKLPLQITLASSESRTYDQTDPYLIACPRISYLPSLLPRLRAFFSPSLIEPNSQPHEGWFSFEGVPLKWHLPVGLLYDLYAGADPASKGTRVDETDHPTSSLNDTLPWRLTVHFSDWPDEELVRLDADGMVMHDAFINSVKEADFLRNGTAKGIMTLSKEDSAGLWQAVQDVDLLSFQRISNILLPPPNQPFRNVPIRFFLPLSPDSGSPSLKVVQSPLPPNIPATTNTSQSTNLRHSPATQVQTLGSALHSLLPNLFPSRRTPVLAKPVLHGAAVPMSAPIEELVRSCAYGDGWVYIVIRMMG
The following text describes a protein:
Function:
Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.
Sequence:
MMLNRLETGSLASAFRGSREEFVVSRGRSPGRSQSIQVRASSGGDPAGWLQTASKQLGKLSSFGEKRKTATSTSTRGPSGDNVQYTGVATTMKKLKVLDLIDRVADIQDDTSEIVGGKRVTVQLVSKDVDPKTGESMKSSEVIFPNWAGLEGPAASLIDFVLEFTVPKSFGVPGAILVKNAHPNEFLLVSFELELHDKSKAHYVTNSWVYNTEKTGARIFFQNTAYLPDETPASLKALREQELINLRGDGTGERQIGDRIYDYAVYNDLGNIEQNEKFERPNLGGNDMYHFPRRMRTGRRNTTVEAKKFPGMVYETRKTKGDFYIPRDEAFERAKMSDFLADGFRSIGHSVSSKVTGFVTRKQEFDTVEEIKKLYAKKGEKVGGINNVLPDKEDIPEQEQYPLVFLQEVLKPDGKMEHPLLYPLPQLLQADDTSWRSNDEFAREFLAGLNPVMITRVKEFPIRSSLDPAEFGDPTSAITKDHIEGSLEGLSVEEAVTSNRLFVVDYHDAFLPFVAKINAQQNSATYATRTLLFLSKDGILKLLAIELALPPKTVGEERITRVLTTRKDDQLWKVNWEWELAKAHVSNNDITAHQVFSHFSRCHAVTEAVIICSNRNLSKLHPLMQLLAPHFKSTLEINRQARATLIAAGGSIETHFTTRAYSLEMAAVNYKDTWTFESQALPTDLVARGMAVPDPDSPHGVRLVVEDYPYAADGLELWGALKAWHKEYVDIYYKDDAAVLQDSELMTWWTEMREKAHEDKKDSHGWPELNSKEALVDILTTVIWIPSCLHAAVNFGQYDFAGFMPHHPTLTRRLLPEHGNEKDKADFNKNPEKYYLTSISNIDSTTTAMSVYEVLSAHCPIEEYIGERRGNWTNNEKVLAAFKGFKESVNEADAVMRARNADPKLRNRGGPVKMPYQLLRPHSKPGVTSMGVPNSITI
The following text describes a protein:
Function:
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.
Sequence:
MPLAMASQDAQNFFQPLSSWISQVYEALQQARDALSASLVNFSKQDSKGSDKLDQDLDDIQIQETYFEDEEQSNDWTQEDTNSLFLEVDHFSCCNSDFQDSAQNSSPRLSRHAKDSCSVASQWPSQTLDDQKPPHVLSSIADEEHHLGKQRSGLQHDFDGQLSGILENVNGKKQVNKFGDDEELSTSSDTDEEVIKQFEISVSRSQSLRSGASEKGRQAGLEQKPKARRWLSTHKEDSKEVPACKGLDGASQPNYSEHLSYGEDGPISAHSWSPSELGDTRQQGTSPQETCVVRCLSRQSTEGSLEMEAAFNNRGFEDSYATDSSSVWSPEEQDRTSFQVPSGVPEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPNKKQRGRTGIQRGPNPIFKEKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEGLFYLSHLHQEGEMKVTLVLEPRSNISGGESPLSPSAVSHSDSASSTQSLSHGGAPELLVGLSYNATTGRLSVEMIKGSHFRNLSVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEERDHWEEMKETKGQQVCRWHTLLES
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAASAAVFSRLRSGLRLGSRGLCTRLATPPRRAPDQAAEIGSRGSTKAQGPQQQPGSEGPSYAKKVALWLAGLLGAGGTVSVVYIFDPILVQQLRRTYKYFKDYRQMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLHPEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWDGNSDDR
The following text describes a protein:
Function:
Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.
Subcellular Localization:
Cell projection, cilium, flagellum.
Sequence:
MPQTDKQICIPPELPELLKQFTKAAIRTQPTDLIQWAADYFGAMSRGEIPPVRERSERIPLSNWAELTPELLKILHSRVAGRLIIHADELAQMWKVLSLPTDLFNSVMNVGRFTEEIEWLKFLALACSSLGVTIAKTLKIVCEVLSSEHDGGPPRIPFSTFQFLYTYIAEVDGEISASHVSRMLNYIEQEVIGPDGLIKVNDFTQNPRVRLE
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSVELRKTFQESPVEITSTGFDFYSADEIRHMSVKEITKGTSFDLLGNQELEGLYDPALGVFGKNTICPTCGLTEEGCPGHFGHFELEEPMYQPLLLTELLKLLRSICMKCHSLKASKQVILGAAIEFERLAKNDIEGAMDIHGLVKEAQYIQRKANASRGKLKREQIEDEENLTVEREVDKELESIFKKECGKGIKKDISFIHTDTHCKAVRNELIAHMVALKDKPCPYCKTVSPKIVLNDSKTGFVFYGENTDAAKNRSEHKYETTPSYIMNILKEAWGHNEIQNEVLSRMYYSQMRGGEKLDVIVPSYHMFFVEVLPIPPSRFRQLNKFGDLISDHPQSIYYRTIIESSNALKVRREGTALDYPEKYFIDQMQKAYNLLILTGNADEGISMKSILEHKKGLFRNNMMGKRVNYAARTVISPDPFLPTNTIGMPLPFAMRLTIAVPVNERNYEEMKQAVINGPQVWPGALYIENEWGHKIVLLDDSNPYNKTKRQGEAERLLVIDPKAPRSFKTVFRHVIDNDMVLSNRQPTLHKPGIMGHYVKVLKIEKTIRMHYANCNTFNADFDGDEMNLHLPQSMEARSEVMNIALSDEQYVVPKNGQPLRGLIQDHVISSFMLTKRDTFFTKEEYCQIVYTALYGIYEQYSIRIPMPAILKPIPKWTGKQVVTAILMHISTNHCTINFEGKCKVSTNEINRGGYQTKKERKLMKQKDEFTEKWSGANDSLCIIKDSQMLTGTLDKNQIGASNQSLIHAIYELYNGKVSGMCLTLLSRLLTTYLQRIGHTCSLDDCMLKPEFDNKRTEMLNKTNELARTAIAKHFKLEGHSKYDIDLALANARRRPQLSKELDDAVKTEVNECTSNVIKECIPYGQLRAFPWNSLALMTTTGAKGSKVNHSQITCLLGQQELEGRRVPVMATGKTLPSFPRYDTSARAGGFIASRFLTGVPPQEFFFHCMAGREGLIDTAVKTASSGYLQRCVIKMLESLHVEYDYSVRESDGSIIEFMYGDDGIDVMKSGFLNNIDFWANNYDALVSKYETKAILSKFKKGFSRACKLQKKCLRHPEKYEPVQSIYSPSNNLAAVSEKYYKLINDYIKEDKRGEFKSGKLDPETFKVMMMLKYNKSLINPGEPVGVLAGQSIGEPSTQMTLNTFHLAGRGDVNVTLGMPRIKELVMFAKKEIATPSMILYLKEPNQKNTEKLAKLLTKVTLANIIEGIKCLDSIIVHEGQRRRQYTIDLTLIDKYEEVVDFNTTEITKKIKSVLMNEIAKRQQSKVGIDIDYKGVSGEEAEEKVNEESEDVQEKINKGKVIEEEVPEEEQNEMSEEEIETEEKSGSSSSSEEEEKEEKKSPLEEEKEEIKEKPNLVEKEEKGKKQHLVVSVLLNVNDKVSMVSVVEKVIEKIILYECPHIVRGIPLSKKKEGRTIYYVMTEGVNFRAALQFGNLVDVDTVETNDVYAVLNMYGVEAARTVLIHEIDSVFKAYGIDVDPRHLNLVADYMTYEGEYKSLNRSGMDHNPSPFTKITFETSLGFLAKTCVSGQKDNLRSPSGSVVMGKNMVFGTGAFDIYTELSDE
The following text describes a protein:
Function:
Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
Sequence:
MEKQQAGQQQADGPMRVLVTGGSGLVGRAIERVVKEGEGREGEEWIFLSSKEANLVSAEQTRAAFEKHRPTHVIHLAAMVGGLYRNMRQNLDFWRNNVHINDNVLNMSHEFGVVKVVSCLSTCVFPDKTKYPIDETMMHDGAPHDSNYGYAYAKRMIDVHNRALYQQYGRKYTAVIPTNMFGAHDNFNIEDGHVMPGLIHKTYLAKKEGKPLVVWGSGRALRQFIYSLDLARLFVWVLRNYDEVEPIIVSVSEEEELTVKDAVDAIVEGFGFKGEVIYDTSKSDGQIKKTANNGKLRRYLPDFKFTPFKEAVKETCDWFAANYETART
The following text describes a protein:
Function:
Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein rad18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats (By similarity). Plays a role in surviving topoisomerase-mediated DNA damage.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKRKVQKIIDEAPLEENSPPRFFDSDVEADSKPNDLTAANSIVDLKTNSQHENANAAGKEYGDSGVSESWVLDFLSVTGEKTISEFLAQKIWKTSNGDLNVAVDMYFDESFNIKNSNPDSESQKDTDASLTQMDQLSNTVSVKDLSINRNTNKKALNAVSPSLNLSSNSSVQDVSIDKEEMMKKQSRNALTPLDFIMKKNELMKYIGCFGVEAYSTASGTRTLQAGERIYLERQKLSIKSQSRNSRKKSKLLSINSSCYSNIVRFCNSDHHEIGKLPTEVASVISTLMEQGFWSFEAICIYSDNIIRFGSNVTLQVYCFINVNHPSLNRSPFTLATNSMQEEEEHLKASFAQNKRDHLLRLFTWIALEPDLEDCNTKESIHIDDILKTSSLPEARDESNSDLTPSSTEDEEDVVSDQLAILYDKVKTSGAELPSAPKPSTFALDLREYQKQALYWMCCKEEGVQSDGSAPKLHPLWSRFRFPKDSEFPEFFKCSSDDDNTHFYVNLYTGETTMLFPNSMPYHRGGILADEMGLGKTIEVLSLIHSRPCFSTDEIPEAFRHSKPSLPVASRTTLVVAPMSLLDQWHSEACKVSQGTKFRSMIYYGSEKPLDLKSCVIDTSTAPLIIITSYGVLLSEFSQQSHSSGLFSVHWFRVVLDEGHNIRNRESKTAKACHSISSQNRWVITGTPIVNKLDDLYSLIKFMRYEPWCNYTYWQTFVSLPYQSKDVLKALNVVQSILEFLVLRRTKETKDRNGNSIVTLPPKTVKIEYLDFSDSERKIYDSLYTKAKSTVNANIVAGTLFRNYTTILGLLLRLRQACCDPVLLSNMTINSETFDDFEFSVEQFNSLINQFVVTGKPIPSDILKIDTLKSFEALITECPICCNEPIQNPLLLNCKHACCGDCLSEHIQYQKRRNIIPPLCHTCRQPFNEQDVYKPFFVKNNGTQSTLLVGEEVKWKYWNRLQSVKLNGLLGQLRQLTHSSEPEKVVIFSQFTTFLDIIADVLESEKMGYARFDGTMSQQMRSTALETFRNDPDVNVLIISLKAGGVGLNLTCANHVFIMDPWWSWSVEAQAIDRIHRLGQEKPVFVTRYIVRDTVEERMLKIQERKNFITGTLGMSEGKQQVQSIEDIKMLFEY