lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MYVSFFSLIFCFYVSFYILFITLFTKKNCLCIVLKEREESYNIILKKKNKTKQNKTKYFVHNFFKKNNVHPYYKSIRIFPGRTFLPYYQNVKDKKKRNIKLKDNNNNNNNNKYNSICNYYDNQNVKTNKKNLPPYNNIKNQHDHVVSTSNNHINMMSNLLKKKKKKKKTTFSKKEMLNIKKKNDKFKFLNTKQNKYIYNKTKHTHMKYIKDNKKRNSLGKDKQNILLIDKQLNNTEYKSNIEQQKQDNNHSYFEKKEKKKKKKKIHKFKTSKKQENILNMFENNLNYSIDKLNKKTKKYEIFTQKENIKSDVLQNEILKKILSKDTKSKNKHDQVKNKDDQVKNKDDKIKNKHDKVKNKHDKVKNKKDKIKNKKDKVKNKDDKIKNNNDERQNKIKMPINNNQNNFKHQDKCNINHQHENNKIKHYIDDITNQQNEQNNKDLHNCLNDHQHIHNKNIITEHTNYLHNHITTNAHVNNNQPIINIQQIFQVSKSVDNFRRQIQIKYNKQNNGNEIKKRLQQYDCIIDFNANKNIITQGIAENKNEKKNEKKKINKNYTFYDVGIYDNFINIYLKYNDINYTTDHQAEYIPIILFFLNNVKNDLYNCYKQMITYHNNNILNHNSNILSKENEKKQPFSTYNISNLCSPDQMVINKKMNQRQSTHVDEQKDTSCHIKNVYNNNDNNFVIQNNELLTSNLLIKDNNINSKQNQDMPNKINFAKEDDNKKCDEKNYMDDQKCGEKNYMDDKEKTSNIKQILYVNKYNEKLKKLIRTFFLHCPTGTGKTFIYLLPLFQEISNYNFLEYEQNQIQTKESYDENNLFCKHKFFYANKNINEQLTSFLCVNKTEEQIFRNYNIERMKHIFNSIINQNNQVNLKTENTTNGSLNNEKEYAFHEKKKLNDNHKNHIYNTERQKKKKDILLITYNKELAVQIYELYKDIINSFYKSYDASFFKNNNSIIYPSSIQKHGQMLIEKLNINFKEKLNMNVHLLIGGNNIKYQLKSLKKKKNNNIKNININKNINVNKNINVNKNININKNINVNINSNNNSNNNYYYDKDNHVNDKMDRHHINDKHSNEQHVIQSSFCDEENINIYIGTPGRLHKLIHEKKIIKLNNISTVIFDEYDFFFNSMKVKNNLKNKEHVVELENQFFAKLLKSIYLKNKEEIVQKKKSIKDTKNIHHYKNNNSVINVICCSATSAIYPYLTYTKHIITTNFLNNLYSELISDKYITDQNYKERKQIQNEDITKKKKEIVSDDNDNDNDNDNDNNNNNNNNNNNNDGDAIYSSSSSSSCSNSCSSGAGLHLNNQKNNDTEQTNNSFINYKKEQIMLNDLFKINNIVKMPKNLIHLNYCYDKKNKERNNNATSNFLRVLFSNPLNKNVLVFCNTKKKVLDLWSLFRNRFDVDIQTIFSQKDKGKKKIFKDINYANFFKNDLIDYKNLKKYVNFLFISTNLLYRGINCMGFTTIINYDMPFDTTEYVHRCGRIGRINNKGAIINIFEKKMKRNYNKEIFNKLNIKTYDIDCYMNNMFTFKEKVKRK
The following text describes a protein:
Function:
Hydrolyzes malto-oligosaccharides, but has a low activity toward soluble starch.
Sequence:
MAGLKSFLASSWLLPVACGASQSIVPSTSATAAYSQFTIPASADVGANLVANIDDPQAVNAQSVCPGYKASDVKHSSQGFTASLELAGDPCNVYGTDVDSLTLTVEYQAKDRLNIQIVPTYFDASNASWYILSEELVPRPKASQNASVPQSDFVVSWSNEPSFNFKVIRKATGDVLFNTKGSTLVYENQFIEFVTLLPEEYNLYGLGERMNQLRLLENANLTLYAADIADPIDDNIYGHHAFYLDTRYYKVGGQNKSHTIVKSSEAEPSQEYVSYSHGVFLRNAHGQEILLRDQKLIWRTLGGSVDLTFYSGPTQAEVTKQYQLSTVGLPAMQQYNTLGFHQCRWGYNNWSEFEDVLANFERFEIPLEYLWADIDYMHGYRNFDNDQHRFSYEEGEKFLNKLHAGGRRWVPIVDGALYIPNPENASDAYETYDRGAKDDVFIKNPDGSLYIGAVWPGYTVYPDWHHPKASDFWANELVTWWNKLHYDGVWYDMAEVSSFCVGSCGTGNLSMNPAHPPFALPGEPGNVVYDYPEGFNITNATEAASASAGAASQSAAASSTTTSAPYLRTTPTPGVRNVDHPPYVINHVQPGHDLSVHAISPNSTHSDGVQEYDVHSLYGHQGINATYHGLLKVWENKRPFIIARSTFSGSGKWAGHWGGDNFSKWGSMFFSISQALQFSLFGIPMFGVDTCGFNGNTDEELCNRWMQLSAFFPFYRNHNVLSAIPQEPYRWASVIDATKAAMNIRYAILPYFYTLFHLAHTTGSTVMRALAWEFPNDPSLAAVGTQFLVGPSVMVIPVLEPQVDTVQGVFPGVGHGEVWYDWYSQTAVDAKPGVNTTISAPLGHIPVFVRGGSILPMQEVALTTRDARKTPWSLLASLSSNGTASGQLYLDDGESVYPEDTLSVDFLASRSTLRASARGTWKEANPLANVTVLGVTEKPSSVTLNGETLSSDSVKYNATSHVLHVGGLQKHTADGAWAKDWVLKW
The following text describes a protein:
Function:
Involved in the digestion of the blood meal.
Subcellular Localization:
Secreted.
Sequence:
MTQKTMLLQLLLLVAAVAASLANELPSNLTLLDANEIPQRYDEAQLWRIYNISEAMQKRVPVGQMLEQKFGGNIWKENSKFLDISIARDQLKAARSFLSAHRLDPQILSHNIQSMIDEELLEGIQSSSFGHGRRTKKAARSSMHWKDYHDLETIYSFMREIRTKFPNIVRLYTIGQTAEGRDLKVLRISENPRENKKVWIDGGIHAREWISPATVTFILYQLMSDWENQPAHIRGLTWYIMPVMNPDGYEYSRTTNRLWRKNRSPSRRAQCSGVDLNRNFDIGWNGYGSSTNPCSDTYRGSAPASERETRAVAEFLAKRKYNLESYLTFHSYGQMIVYPWAYKAVKVKDASVLQRVSSLAAERILQKTGTSYRAAVTHEVLGIAGGGSDDWSRAALGVKYVYTIELRDRGAYGFVLPPRFIKDTALEGWTVVETVAQAIGPSSSG
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MDYEHEDFTKPVESLESMRQKFAQIAHSLSHFLALLHQHRTLVPWSAIHKNFSILLSQLHSLTNTLISQSQTLKTINIFPSDLFPVREQEPLLTTLLRTKALPAVEEWENSTLQSVEGDITDEEVNQQVNASSQLWEEARTFLLTERENYNWVGTVTRKQENEGEFSDQKDLEQQRVAEEATADTSLMDLLRFMKSGRR
The following text describes a protein:
Function:
Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The acidic C-terminal domain mediates interaction with histone H3/H4 complexes.
Sequence:
MDFDSVLSIASQNQGLSSLPKRYSLKTGPPKKDLKVGGVNSAAVQAFLKKKAVEQKNKEQQDKKAKEDLLAKRVELKSDRKARAMASRTKDNFRGYNGIPVIDQPKKRQSKGSSTEEQQSSTKYEGGDYDDEDNFDYEGTDSESEPSRPVKPQAISRPEYSNRVENKPKKLSAPARPASSSMNFADLLKLAEKKQFEPVELKVVKKTEERLRTAEEIRELEMERRVKKLDKGKDVRSDKNSGQKDSRSQTSSNPQKKHVDRDGKNGRFPRPSEEKHQSSSTSKKPKLQASSERTPTSAKLHGDRSNSGSSGALNSKSAMKNGASFQAKQAPPRPSQGQRPATPSDLTPRKGNVSLTQAKSSISGSCPPGAARPGQGPHKNSAHGRPSNFSTSGPSQKPANPGKLSRPGSNAPPRPGGSGVVRPFTGDPSKQPRPGGNLQSQQFPGSSRASLNGPKRMERGVSGSQINRMSSGPGRSQCTVVSETISTKNITPRPGMVQRPPGPQGPRTVIGPSGHRILVKPSGPALPPITSSYKRKFEDEEEYDSEMDDFIDDEGEDQDEISKHIREIFGYDKNKYKDESDYALKFMESSWKEQQKEEARSLRMAVLEDEEEERRELEEMQRKNAKKRK
The following text describes a protein:
Function:
May be involved in podosome and invadosome formation.
Subcellular Localization:
Cell projection, invadopodium. Cell projection, podosome. Cytoplasm.
Sequence:
MDRGRVLEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASILQSLQPLPAKEVSYLYVNTADLHSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKAASPEPAKSPCLRNAANLPPPLPNKPPPEDYYEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYNDSDAMSSSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQLTVIREDQLLCYKSSKDRQPHLRLALDTCSVIYVPKDSRHKRHELRFTQGATEVLVLSLQSREQAEEWLKVIREVSKPVGGAEGVEVPRSPVLLCKLDPDKRLSQEKQTSDSDSVGMGDNCSTLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIISFSKKKPLADDLQTSSTEEEVPCCGYLNVLVNQGWKERWCRLKCNTLYFHKDHTDLRTHVNAIVLQGCEVAPGFGPRHPFAFRILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNSFLYARSCQNQWPEPRVYDDVPYEKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRSKEERRIDLELKLVAVKERLQQSLAGGPALGLSMSSKPKSGETANKPKSSVPEQSLPVNCVSELRKRSPSIVASNQGRVLQKAKEWEMKKT
The following text describes a protein:
Function:
Involved in the hydrolysis of the beta-gamma-phosphoanhydride linkage of triphosphate-containing substrates (inorganic or nucleoside-linked). Catalyzes the hydrolysis of inorganic triphosphate (PPPi), however it does not display significant activity towards long-chain polyphosphates. The existence of PPPi in living cells is still unclear, and PPPase activity might be the ancestral function of CYTH domain. It also has gamma-phosphatase activity on NTP substrates, but no adenylate cyclase or RNA triphosphatase activity.
Subcellular Localization:
Nucleus.
Sequence:
MEVEVKLRLLTAAAHLRLTTLLTPYHLKTLHQRNTFFDTPKNDLSLRRAVLRLRFLQNAAVSAASPSPPRCIVSLKAKPTLANGISRVEEDEEEIEYWIGKECVESPAKLSDIGSRVLKRVKEEYGFNDFLGFVCLGGFENVRNVYEWRGVKLEVDETKYDFGNCYEIECETEEPERVKTMIEEFLTEEKIEFSNSDMTKFAVFRSGKLP
The following text describes a protein:
Function:
Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.
Miscellaneous:
MISCELLANEOUS: Present with 623 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSDEAKEKRELESQKESSHNKSEKSVEPKPKRRRRRNYDDYDAEVAKEETKAKNGLTKSENNGTVEDSESDMDDAKLDALMGNEGEEEEDDLAEIDTSNIITSGRRTRGKVIDYKKTAEELDKKEPSTGSKDDVGYGEKEEDDEDEEDDDFKE
The following text describes a protein:
Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. ski6 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MSDRKRVYGPSVSVPPYFEEPEQPVFTRTRDVDRCRKIYLKLGWATKAVGSSYFESEKIKIACTVSGPRPSKTFAFRSSAKLNCEFRLSPFSTSVRQGHVQTVEEKSYSQMIEAAISPSILLHLYPKSSIDVYIQVIESDGALATLAAAISCASSAIADANIDCIDLVTGSSVLFNPNTDEYWIDPDYVDERARAAKGSVVMGYMASLGHVTQVWERGTCSPSRLSFLTEKCIKNAKDTRLVINHALLLEKSKSEDP
The following text describes a protein:
Function:
Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance; Multifunctional protein that functions as a downstream effector of RALA and RALB. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity. As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis. During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of RALA. Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
MEQTIWWYFFLQRSIREAKKHNKMGLPMQIFTEDIAGCDTPLYVTATNFDVVNDIISKLLPMIRKHNIEDYQLWFCPGPGKAPRVLQGHEYPHDIRMINIQKNFSSRDLRNFTAFCSLHGVIMKYLNADVHGKFILKPRNSARSQQQNNMKEKTFKKQRTSMTSQLDRGSVPHQDQVCTTPPVKKGRKLFGRELSSICQDGILPAAILDMLYLLKKKGPTTTGVFLEPPSITLWQTVKDKLDSEEEVDMNKQSVNVVAWIFKDFLQNIEGSLMTSKLYDEWIRVPEKVNDEEKLAAVQSLLDKMPPENAALLRQLFCILYEIKSNCSVNEMSSYHLSVGLAPCLLFVPSFCNNGVTNDIGKKISLVEFMIENSTKVFGEDLAAVGLGTSLYHPPGGKSSCSQNNATNIGNIKETEHGLSSCPIGRTCTPGYNTLPKSPAASLPYEGLIDSQKHEGIVYTNPTVTSINPPQAKQKCLFGKSLSGLLEDKTLPTPKLGFSMTESFLHPTSSPSEHRRAEHGSGLTWTPSSEEISPTKFPGLYRTGEPLPPHDILHEPPDIVSDDEKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAENPSKMKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEEKHKEKKCKVLMAADVVKEWKEKKKKKKPTQESEVPQTDAPSLRPIFGVPLADAVERTMMYDGIRLPAVFRECVDYMEQHGMKCEGIYRGSGVKSKVDELKAAYDREESPNLEEYEPNTVASLLKQYLRDLPENLLTRELMPRFEEACGRTTETEKVQEFQRLLRELPEYNHLLLSWLIVHMDHIIAKEIETKMNIQNISLVLSPTVQISNRVLYVLFTHVQELFGTVVLKQVTRPLRWSNTATMPTLPETQTGIKEEIRRHEFLLNCLHRDLQRGIKDLSKEERLWEVQRILTALKRKLREAKRQECETKISQDIASLLKEDVSEEETSENEEDINILLAQENEILTEQEELLAMGQFLRSQIASEKEKVHCLRAEIAEIQSHQHGRSETEEHSSDSEYDSKDEEELQIILEDLQRQNEELEINNNHLNQAVSEEREAIVELRVQLRLLQMQGAKSEQQLQEEEPERQGDTGPLPCEGVPEVIAAKEQVKPSPSKDPKETDLNCPGPVHHTVSQSPLPVLPGSVL
The following text describes a protein:
Function:
This protein binds to 23S rRNA in the presence of protein L20.
Sequence:
MEPYAVIQTGNKQYQVRKGDVIDVELLDGISEENKEVLFQDVLFTFDGEKASVGAPTVGNAVVKGELVSFVRGEKVVAYKYKKRKNYHKKIGHRQNYLRVKISDLVM
The following text describes a protein:
Function:
Receptor for cAMP.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKDIILIYMICAPISMIGSLFIIITWLLYAKLKNSGSNFIFFQAISDFFFTSKYIITIIFYYINIPQFSDETSSTDTNPYCFSLGLFSQFFGQATIMWSYTMTVKVFHSYFEMKKKNNNNNIGSNNIGGGGGGNNSNKQNSIDKTLKWYHLFVWGFCLVNATIIGISKQYGPSSTGCWIVGANNPYRFFELVPLYFTITTSIIILILILVKMKKSKPSSLLPTESMRYNQQAREFKIQLMKFVLIFIIFWLPATVLRTLEYFGIEKTFFILLDAVSVSLQALANSLVWATSPQFLKLMKRKVVNKPNKQMEREYLINK
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MRESRGMTVMKSPVAHPEGLSGIKTWVLSPWRIVDDCGGAFTMGAIGGGIFQAVKGFRNAPSGMSHRMRGSLTAIKTRAPQLGGSFAVWGGLFSMIDCGLVKVRGKEDPWNSITSGAMTGAILAARNGPVAMVGSAAMGGILLALIEGAGILLTRFASSQIPTGPQFAEEPGPAPMPSPPFGDYRQYQ
The following text describes a protein:
Function:
Probable oxidoreductase.
Sequence:
MKCKVSFPLCNLIYFFISMTTVLVSFLRQKEKKKEDVSAFPQASEDNHSLNFGIIGAGHIGNQLAKTFLQLGGISYKNIQISTRRPETLSEFHMVGVKCFYNNRQLVSWADVIFLCCLPSQLQHICSEIRDAIQNQCIIYSLVTGIPLTRLKQLLSFNSILRPQYKFVETDLFDIWLASRTVVEALNDPAVIQATCPCNPIREVVVNREWLAATFYAALNSYTMQGLTYAKTLLLFTDVCFPDDNTLLFCENFINPTFASSLAPDDSFPWFDLTTVQLKESPFGHLLATDKFFQDNIASLYCNMLAVRFSKTNEDSMAVPFKKPSLSALLLNPTKSLTWGFAATCKSKVVETSSTDSEET
The following text describes a protein:
Function:
Negative regulator of epidermal growth factor receptor (EGFR) signaling.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein.
Sequence:
MDFMVPIHTMSDGSPPPSICFIRAAESYPKSQMEKEDSQLFVPFQELAGESIKYLGRTDDGILALSNYRIFLSKQSTGYETYVPLGLIESVQVRDLFQLIVNCKDASTVRCSFPSAEQCSDWQRRIHLMIGVPESLETLFAFPFYSWTCDVLGSGNGSGIVSAQANGNGLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMSNRLQRSVRYESDFKNEVARLGFDLKGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLPAVVWRHQKSGAILARCSQPEVGWLGWRNTRDEQLLKALADACAFDRGEHARHSTCANAKAQPTKGSKETNGQSGLSGKSSPSLDDSSHEELTLDEIKKILIVDARSYTSAVTNRARGGGCECIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLCASSPDDPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNGPNSDEVNERCPVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIENSVFDRTFSVWPFLAETMYRNPLYKHETEKVLWPAHSVRFLYFWSDVYLGSLGNKNGTDLPLLSNERQSGHNGLMAKTRSSEDLTTNELGQSTISRRSSDPNLTVESIVTDCFNANSNSMFDIRSEANNSVSENVQESVKDSKEVELDVTDATEVGPCGRSNNPIPDFHNDQSTASKRDILEVESQTQRRSSLESSQLIPGSVFIFGSSENDKNAVPSESEESLATSQKLNSESGRPFFIFGSSENDQSPVPLKSEDTSDISRALWHGAIETSTDTLIPAEPVQKPNSDNSSRDHITSPTMELVSGDRKLESTSTVQASKISQSYNNLPKVHIRPNAVICPQRVDAFPHHLDLQVPRETTGNPDRCKPEKLAKDANANANANGSLLASDGYNGEESLFISPDLQRFVGQSPFDAPSTGGRIRRNTFGSSYSRDMKFTAENGSAHQFPSSGIISLPPTPFQERAQFTISCPDGLAHGLSEQNIRLHQIVQEHKLREEMLLREIHGMRLALLEKGCPSCNSIVSTNMEHENGSDIVENASTCSWEAVEERSGPASYAPSSIQEKKASSVLWVPDHAVSRCSSCQTEFWLGRRKHHCRSCGEIFCADCSEFWAPLPNEKLFNPVRLCGSCYTSVTTNVQEYAAVPAESQAKDDETSSAIS
The following text describes a protein:
Function:
Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression. Component of a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.
Miscellaneous:
MISCELLANEOUS: Present with 1470 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MIPKLIVFGGNGFLGKRICQEAVTSGYQVVSVSRSGKAPHSNELNDKQWMQEVQWTAADIFKPDSYHELLNNATNVVHSLGILLENENYKQTLSKSPTYDSKSRLLSFGAGPNPLKKSSPYFTYEMMNKQSAIILADTFKQKILKKSKKEQEKANQRSFTYISADKGFPLIPSGYINSKREAEIELEKMQRYFRPIIVRPGFMFDEHRNAIGPRSFIHTALELLYCGNKFLLRNKLQLLNDLIRPTVSTQQVSKSVLKNIENPDFKGVVTLEEILKA
The following text describes a protein:
Function:
May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
Subcellular Localization:
Nucleus.
Sequence:
METGFPAIMYPGSFIGGWGEEYLSWEGPGLPDFVFQQQPVESEAMHCSNPKSGVVLATVARGPDACQILTRAPLGQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLLQ
The following text describes a protein:
Function:
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
Subcellular Localization:
Cell membrane. Cytoplasm. Nucleus membrane. Nucleus speckle. Nucleus, PML body.
Sequence:
MSDQEAKPSSEDLGDKKDGGDYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRISDHQTPKELGMEEEDVIEVYQEQTGGHSTF
The following text describes a protein:
Function:
Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction. The second half-reaction is the reverse of the first, transferring the amino group from the pyridoxamine to a second alpha-keto acid to form the product D-amino acid via a ping-pong mechanism. This is an important process in the formation of D-alanine and D-glutamate, which are essential bacterial cell wall components (By similarity).
Sequence:
MEKIFLNGEFVSPSEAKVSYNDRGYVFGDGIYEYIRVYNGKLFTVTEHYERFLRSANEIGLDLNYSVEELIELSRKLVDMNQIETGAIYIQATRGVAERNHSFPTPEVEPAIVAYTKSYDRPYDHLENGVNGVTVEDIRWLRCDIKSLNLLGNVLAKEYAVKYNAVEAIQHRGETVTEGSSSNAYAIKDGVIYTHPINNYILNGITRIVIKKIAEDYNIPFKEETFTVDFLKNADEVIVSSTSAEVTPVIKLDGEPINDGKVGPITRQLQEGFEKYIESHSI
The following text describes a protein:
Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Subcellular Localization:
Nucleus.
Sequence:
MKPPPRRRAAPARYLGEVTGPATWSAREKRQLVRLLQARQGQPEPDATELARELRGRSEAEIRVFLQQLKGRVAREAIQKVHPGGLQGPRRREAQPPAPIEVWTDLAEKITGPLEEALAVAFSQVLTIAATEPVTLLHSKPPKPTQARGKPLLLSAPGGQEDPAPEIPSSAPAAPSSAPRTPDPAPEKPSESSAGPSTEEDFAVDFEKIYKYLSSVSRSGRSPELSAAESAVVLDLLMSLPEELPLLPCTALVEHMTETYLRLTAPQPIPAGGSLGPAAEGDGAGSKAPEETPPATEKAEHSELKSPWQAAGICPLNPFLVPLELLGRAATPAR
The following text describes a protein:
Function:
Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
Subcellular Localization:
Membrane; Single-pass type III membrane protein.
Sequence:
MDCQENEYWDQWGRCVTCQRCGPGQELSKDCGYGEGGDAYCTACPPRRYKSSWGHHRCQSCITCAVINRVQKVNCTATSNAVCGDCLPRFYRKTRIGGLQDQECIPCTKQTPTSEVQCAFQLSLVEADTPTVPPQEATLVALVSSLLVVFTLAFLGLFFLYCKQFFNRHCQRGGLLQFEADKTAKEESLFPVPPSKETSAESQVSENIFQTQPLNPILEDDCSSTSGFPTQESFTMASCTSESHSHWVHSPIECTELDLQKFSSSASYTGAETLGGNTVESTGDRLELNVPFEVPSP
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
Subcellular Localization:
Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAPPAPGAVSGSSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPEREVERDVFLYRAYLAQRKYGVVLDEIKPSSAPELQAVRMFAEYLASENRRDSIVLELDREMSRSVDVTNTTFLLMAASIYFHDQNPDAALRTLHQGDGLECLGYMESYLKERGAEDHRFHLGTAGNVNRRAVEMELMATGPGASLSRREARDKWLHESSVFPGAETEADD
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
Sequence:
MSRRKPASGGLAASSSAPARQAVLSRFFQSTGSLKSTSSSTGAADQVDPGAAAAAAAAAAAAPPAPPAPAFPPQLPPHIATEIDRRKKRPLENDGPVKKKVKKVQQKEGGSDLGMSGNSEPKKCLRTRNVSKSLEKLKEFCCDSALPQSRVQTESLQERFAVLPKCTDFDDISLLHAKNAVSSEDSKRQINQKDTTLFDLSQFGSSNTSHENLQKTASKSANKRSKSIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYCHLDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAIGDNRSSLFSRKLTALYTKSTLIGEDVNPLIKLDDAVNVDEIMTDTSTSYLLCISENKENVRDKKKGNIFIGIVGVQPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALSEQTEALIHRATSVSVQDDRIRVERMDNIYFEYSHAFQAVTEFYAKDTVDIKGSQIISGIVNLEKPVICSLAAIIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGTTLRNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEVLHSESSVFGQIENHLRKLPDIERGLCSIYHKKCSTQEFFLIVKTLYHLKSEFQAIIPAVNSHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGDKTELFKDLSDFPLIKKRKDEIQGVIDEIRMHLQEIRKILKNPSAQYVTVSGQEFMIEIKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHLNQLREQLVLDCSAEWLDFLEKFSEHYHSLCKAVHHLATVDCIFSLAKVAKQGDYCRPTVQEERKIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMGGKSSYIKQVALITIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGQSTFMEELTDTAEIIRKATSQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKNYSHQVGNYHMGFLVSEDESKLDPGAAEQVPDFVTFLYQITRGIAARSYGLNVAKLADVPGEILKKAAHKSKELEGLINTKRKRLKYFAKLWTMHNAQDLQKWTEEFNMEETQTSLLH
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGQDNSKQKRQRVEYSGKQDATTPFEISGNSLYNLVGNKDEALFKELGGTEGICKLLKSNQTKGLDGNDLKERYSQFGQNKYPDPIMKTFFQMLVDSLNDSTLMILIASAFVSLFLALVMPKSQTCGEEQEMNTDWIEGLAIFVAVIVVSVGSSISDYNKQKKFMELSQDEKNVNIKVVRKGENTLISIRDLAVGDLVNLDVGDIIPADGVYASGFDLRVDESDMTGEPVAVKKSEKDYWMMSGTKVTDGNGQMIVTAVGLNSLWGKTKESLNQDKPRPTPLQEKLDELAEQIGKLGMGCAIVVFTILCIYWVIDAINYKPILVCDNDPCKQWTEESKATHNCELIGFNWMHLASVVEYLITAITIVVVAVPEGLPLAVTISLAYSMQQMMADNNLVRHLKACEIMSNCSNICTDKTGTLTENRMTVVRGWFGGEVMERDKSLDLNNTKLGEEVYNNISCNKSISSAVYMEDGILKTIGNKTECALLGYCLKQNIDYEARYTKLSSIIYQQFAFSSARKRMSTIIYNEDKSLHMFLKGAPEVILSKCSKYMKKDGTTVILTEDDRKTLLDFQLSCANQGMRTLSLAVRDLSPKNPSNLNEKYEESPEEDCTLLCVFGIEDPLRPEVIDAVASCHRAGITVRMVTGDNIATGRSIAKQCKIIESDSDFCIEGPQFAKLTDEEVDNILPTLRVIARCSPQDKKRLVNRLILHGEVVAVTGDGTNDVPALKEADVGLAMGIRGTDVAKQASDIVILDDNFNSIVKAVMWGRCVYDNIRKFLQFQLTVNVVALALCIIGAITKMGSPLKALQMLWVNMIMDTLAALALGTEKPTPSLLNRKPFGRKASLISINMLRNIVTQAIYQLFVLLFLLYCGRELTFLNAPCAYIDHGDFGQYKCADNKLHSINDIEKDTTTIQTMIFNAFVFCQIFNEINSRKVNGEIDVFENIFSNYMFVGIVSMTAIVQTLIVVFAGPIFSVTPFPGIGIIQWITCLVLSSLSLVIGQLAIRYLTETQILQIKENFFGKAKSD