lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Ceramide-binding protein that may transfer ceramides from the endoplasmic reticulum membrane to the cis-Golgi network membrane, and is thereby required for the biosynthesis of complex sphingolipids.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Localizes to the interface between the cis-Golgi network and endoplasmic reticulum exit sites.
Sequence:
MNWLKSTLASVAGTQEPIYGPEAIQSVAQQAQQTPYTELTKDDLRWRAYQYTNVETETFYVMADNGTVVMVQVIYSNIAGIHTTAQFNSKIFNLKGDQPHIWHSDPLYNFMFDENMLSFGADNLALTLNEEGTAYTIKSAVNEDSLVNLTFTRTAPGFVVGKDGTSYFGTDPANPWGSMMHAFWPRCRVEGTITTKEKTYDLTGRGMFIHAIQGMKPHHAAARWNFINFQTPSYSAVMMEYTTPPSYGSTVVNVGGIVKDDEIIYAGATNSATHTASAHDADSDWPAPTSIKCVWDGKSKDGKDVHAELDGPLGNRLDRVDVMAEVPGFVKTIAGSVAGTRPYIFQVSLSLATGGSVVKLTIGQYSPQEKLSLKLKIGAEEFSEEGSMFSEATFIS
The following text describes a protein:
Function:
Acts as a receptor for octopressin.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MENFTEENLHPWITTTTRVYNNVTIFPQYDDELGKFEIMVLCILCFMALFGNAVVLIVLRIKKTTLTRMQLLIVYLSVTDISVALFHILPTIILKINVYFLGDISACRVYQFITVAELYASSFVLIVTALDRYISICHPLAAHMWTNRRVHMTTALALFLALMCSLPQLDAVLVDFHGGKLCRPNLTTELANIAYSWWAFCSVFFVPLLLLIFFYGRICFVVWQSMRGRECTQSVGSSASRYVRKPIKCRISSQTSSENRVKNYSDARDKDSSRNPRAICRGVSKSKIKTIKLTFSVVACFIICYTPFFTVLMARTYDAELSSAQTPALVILSLLPSLNSCTNPWIYLAFSGKVWCRQQSQNFPRTWTQTTNTYLVELEAKKRTSFGAEHVTFASNSTARKTLNVDDTNTTALMSSSPC
The following text describes a protein:
Function:
Antagonistic role in the Wnt signaling pathway that operates in embryogenesis (By similarity). When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation (By similarity). Has a role in blastomere signaling during endoderm specification (By similarity). Component of the beta-catenin-lit-1 complex which promotes phosphorylation, down-regulation and subcellular relocation of pop-1 (By similarity). Within the complex, activates lit-1-dependent kinase activity (By similarity). Can substitute for bar-1 indicating functional redundancy (By similarity). Appears to have a role in centrosome positioning (By similarity). Involved in the development of distal tip cells (DTC) by regulating the asymmetric distribution of cye-1 and cki-1 between the daughters of Z1.a and Z4.p cells (By similarity).
Subcellular Localization:
Cytoplasm, cell cortex. Nucleus. Note=Located in the anterior cell cortex before and during asymmetric cell division. After division, located preferentially in the nucleus of the posterior daughter cell (By similarity).
Sequence:
MEERGPDIEKYGSQPCTPLSFDPMLPSTSRVATPVRPSSTLSARQAPASPFRAQPQNMEPSISRVHELREGAAVKRSYTNDWMQGNYIPPNPQQQQYQRPPSMIGSTISNMSNLSHMTKFSALSVNTQCGQFDNWIYQSQPALSKVSHSSVENQDPMKRRERMSIPEIVQSLASYEMSDQVAAIRELEPLAKAEALESTYCQADLGKIINALFEVLVPRPQENENVIRKVFEILHRAAVPKHVRMTEKIFHSLNLELMNTNSSKHSFQVPRPYSIYELVIERASRLDTAYDQAAMLLLAQICCKPFFMKYVFSEKEQSAGHRRLHEVVMQFAIKNLQQQETKRKSKGFCVSIIKNLSRRNRSIWSIVYELHVIPIFHDIIKDEYSDEDLLWPTMQALTTFCSIERVGEDFVKLGGAQDLCNLLYHGSTRLLHELLACMQRLSLLQEIGNQDMEESIRRVIQVVGSDDATIAERATGVLRNIGQPNKQNKVIMVRNGVTAHAIAVLRTSMRFQSQLREQQNARTPKNQIDAAKNQILSIYENCLSILNNVTKMGKDDILDSAIQACRMISANPDAAIVLLHFLNAGAPKCRKLAVNVMKRVIENVPAFAEPFVDLPGTTQETLPILLLKRAYESLDEWKKAVVEVMRSEPNTQQFRDAIEKRQDHEDIVWKSVSLLSNLCRNGNPRFFERVKVEMLYTRPTNPFTSLFPEMSDVILYEWLDFILAICGTEWSLQNCLMYHFLKQANITHEYLLHYRRPNPQICDKIKNIIDTGMRQQQQHNQLEQMAMMHAQQQHQQLPM
The following text describes a protein:
Function:
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSEIYYVEEKTTSEPGVDENPILTHWLLKDDIRVCKHCRRTFEASRFSEYAAKQHLARYHTQVDETMSFTQYIQEFSPTYEWGVHKCRLHNERSFSIEFFKYIMAPSKWENELLYYDEHAVIIKDKFPKAQQHVLVIPRAIKTTLKHPTQLSITDKDKYQKHIDWALNYIWHDFTSKYKLKPGSSSPFSSHEEFNSLAHFIANFTQVGVHSVPSMENLHIHVMTTDFYSKSMKHKKHFNSFNTEFFVRWDRLPLAEVPNTDAMERRIRESELTCTYCKQGFSNRFAALSRHLGEEFHCRFVPVK
The following text describes a protein:
Function:
Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle. Also degrades suberin, a specialized macromolecule found in the cell wall of various plant tissues.
Sequence:
MKFTTLATLALGAVSALAAPVTELESRQLFCRDVYVFFARGTGEVGTLGTVVGPGLSAAVKLAVRDSVEFEGIDYPALVSGYLAGGDRGGARTMANKVSQTASRCPNAKIFISGYSQGAQVTHLAARQLSAADQARVTGVVTFGDPYRDDALPGGLQSRRKTYCNVGDLICAGLPTLLAPHFTYGSDTPDAARWIAARV
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and spliceosome disassembly. Promotes release of excised lariat intron from the spliceosome by acting as a receptor for PRP43. This targeting of PRP43 leads to disassembly of the spliceosome with the separation of the U2, U5, U6 snRNPs and the NTC complex.
Miscellaneous:
MISCELLANEOUS: Present with 892 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAIKKRNKIRLPSGSPEEVGIDGSAHKPMQQIKPLVSNDSEDDDNDICVLQPIKFKKVPKRDITFDGEQAIKEDNSHYEDLYHSKKNTNASTRNKDDLLILNMEDLMEGNHHLLSDSSEAGSSSEGEHISSIPTRGEIAKLKAQKSLSRRKISESDVTTERDYVKLLDSEDKREIMETIRLNGGLKRNNEKEITNFSDDEMQGFQDEMLALTDNQIAIQKDSKRKIIEKAINEVPYRTNEEWETQLLSKGNINKSNEKIITPLPVLFPDDDESGNSIERINEMVSKICLQRKKVEMRLQALEKTKIDLEKSKASLINKLIGN
The following text describes a protein:
Function:
Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Subcellular Localization:
Secreted.
Sequence:
MVMMKLSALLIAYFLVICQMYSSHAAPARTGLESMTDQVTLTDYEARRLLNAIVKEFVQMTSEELEQQANEGNSLDRPMSKRCSNLSTCVLGKLSQELHKLQTYPRTNTGSGTPGKKRSLPESNRYASYGDSYDGI
The following text describes a protein:
Function:
A member of the argonaute siRNA chaperone (ARC) complex which is required for histone H3K9 methylation, heterochromatin assembly and siRNA generation. The ARC complex contains mostly double-stranded siRNA. Inhibits the release of the siRNA passenger strand from ago1 together with arb1.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes to a large number of foci in both the nucleus and cytoplasm.
Sequence:
MFRKKKSRVLQRDVNFGNCLEDMNLQITNDFYLRKLNAPNELYEFQVTKDKEYNEKFYFAVLDHVYSWTLQNSLLTRISIPLESSPSEPHSWIYATRNWQTNENGIVIIIQSMSHPLIWSNRNLREGDVRRATVLDVIAKCTEKKLSVVIFSPSALLWDQSINFPRTTRYFTSQGLQITKKSIIKDVETPESYVSIGLNYVMSNSVSTKIHFVGSEYGSYLLNSYLDLNWKKFSGKAGAILLIMNMSINEELHDPDYVSYLIEHARNYLPSHEPCRHLMNSIMTESGIPNFSAGKYIDEFYDYIGDVLLEMIALDTNTSKS
The following text describes a protein:
Function:
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Sequence:
MPEVGWKPKITASRKLLLKSLMLAKAKECWEQEHEEREAEKARYLAERIPTLQTRGLSLSALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVLDLRGKFKRPPLRRVRVSADAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPVEVGDWRKNVEAMSGMEGRKKMFDAAKSPTTQ
The following text describes a protein:
Function:
One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Bacterial flagellum basal body.
Sequence:
MPEKKIDGRRKAAVLLVALGPEKAAQVMKHLDEETVEQLVVEIANIGRVTPEEKKQVLEEFLSLAKAKEMISEGGIEYAKKVLEKAFGPERARKIIERLTSSLQVKPFSFVRDTDPVQLVNFLQSEHPQTIAVVLSYLDPPVAAQILGALPEELQTEVLKRIALLERTSPEVVKEIERNLEKKISGFVSRTFSKVGGIDTAAEIMNNLDRTTEKKIMDKLVQENPELADEIRRRMFVFEDILKLDDRSIQLVLREVDTRDLALALKGASDELKEKIFKNMSKRAAALLKDELEYMGPVRLKDVEEAQQKIINIIRRLEEAGEIVIARGGGEELIM
The following text describes a protein:
Function:
Could catalyze the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and release both CoA and the acetylated product.
Sequence:
MFSKVNNQKMLEDCFYIRKKVFVEEQGVPEESEIDEYESESIHLIGYDNGQPVATARIRPINETTVKIERVAVMKSHRGQGMGRMLMQAVESLAKDEGFYVATMNAQCHAIPFYESLNFKMRGNIFLEEGIEHIEMTKKLTSLN
The following text describes a protein:
Function:
Plays a role in vesicular protein sorting.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MSTYKDNNNHNNHNSNMNTIDQKKFLDECIFVVKEQSFYMKQALENGSLRDTLKYASNMLCELRTSHLSPKYYYELYMLIFNELQHLDNFISDKKKHKKKFIDIYESVQHAGNIIPRLYLLIIVGRNYIKNKDIKAKYILKDMTELCKGVQHPLRGLFLRYFLIQMCKDRIPDTGSEYEEAGGGDINDAFEFLLTNFYESLKLWSRMNDKVLKVPNMIQDDNTMNSKIKILKEKMDVKMLVGSILVRMSQLEGMTKQYYIENCLPKILLYLSNINDCLIQQYIFESIVQVFSDECHIYSLEILLNAILKMNTSIDFKSILITLLKRLRSFIEANNKCDLPKDIDIFNLFYDHLVVYVNRTLDTYTKVNYNDSINRSPNEDHHGYTHNDLSKGKAKDIINNNDNNNDDNNNNKDNDDNNNNNNNNNNNNNNNNNYNYNHNNNQDRYNISKGNVQNGHIKIENMNQTNNDLNNNNIINNMGHINTNDLNKNNTGKNCTIVNTDEFVNNVVKMLQVIYEFIFLCIRIYDDDIIISKLFGLPYTIVSNVNMNNDTICEEIISIIVLPFNYLGLSALNARNMQTLLNSITEKHKKKLSLDIIDAIIECKKKYITYEDVEKILKYISYIFHEKDKKNKNNDEDIFNLENNNSAYTCEKICKFFHIITNTKNIEEKYNICMLFYKYISNSTYLVHLLPTIIFTLLHVVTQITKLGQEDHFNQNDDKNNNMNTIDTIDSNNNNNDNNSNCNNDNSNIDSNHTMDNEKKEDFINSSDSYNIYPNDNDKQNLNNYLHNNQNNFILDEKKINQYNIYVKNIFKFIHTNLLTVASQMPILTFKLFLYSAIVVNNYNSFVQTHEFLTFDNLEAICYEFITQPLIIYEEDINISAQQFDCIVWIVGILCTHINLLDNENYNNIALKLTQHANKLLKKKDQCIGVLKCSHLYWENKKYRNSNKVIECLQKSIKNAEIAIQSNNDNIILFTYMLDKYLYYYEAQNIDVSEETLHYLIDICQDYYNKTNDDTNFKQEYKKVIKYVHDKQKNSNVFQKINIDTSILRS
The following text describes a protein:
Function:
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation. However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703'. Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription. In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation. Mono-ADP-ribosylates PARP9.
Subcellular Localization:
Nucleus. Cytoplasm. Note=In steady state splenocytes the protein is mostly nuclear (By similarity). A minor proportion is detected in the cytoplasm (By similarity). In macrophages, mainly localizes to the cytoplasm.
Sequence:
MAVPGSFPLLVEGSWGPDPPKNLNTKLQMYFQSPKRSGGGECEVRQDPRSPSRFLVFFYPEDVRQKVLERKNHELVWQGKGTFKLTVQLPATPDEIDHVFEEELLTKESKTKEDVKEPDVSEELDTKLPLDGGLDKMEDIPEECENISSLVAFENLKANVTDIMLILLVENISGLSNDDFQVEIIRDFDVAVVTFQKHIDTIRFVDDCTKHHSIKQLQLSPRLLEVTNTIRVENLPPGADDYSLKLFFENPYNGGGRVANVEYFPEESSALIEFFDRKVLDTIMATKLDFNKMPLSVFPYYASLGTALYGKEKPLIKLPAPFEESLDLPLWKFLQKKNHLIEEINDEMRRCHCELTWSQLSGKVTIRPAATLVNEGRPRIKTWQADTSTTLSSIRSKYKVNPIKVDPTMWDTIKNDVKDDRILIEFDTLKEMVILAGKSEDVQSIEVQVRELIESTTQKIKREEQSLKEKMIISPGRYFLLCHSSLLDHLLTECPEIEICYDRVTQHLCLKGPSADVYKAKCEIQEKVYTMAQKNIQVSPEIFQFLQQVNWKEFSKCLFIAQKILALYELEGTTVLLTSCSSEALLEAEKQMLSALNYKRIEVENKEVLHGKKWKGLTHNLLKKQNSSPNTVIINELTSETTAEVIITGCVKEVNETYKLLFNFVEQNMKIERLVEVKPSLVIDYLKTEKKLFWPKIKKVNVQVSFNPENKQKGILLTGSKTEVLKAVDIVKQVWDSVCVKSVHTDKPGAKQFFQDKARFYQSEIKRLFGCYIELQENEVMKEGGSPAGQKCFSRTVLAPGVVLIVQQGDLARLPVDVVVNASNEDLKHYGGLAAALSKAAGPELQADCDQIVKREGRLLPGNATISKAGKLPYHHVIHAVGPRWSGYEAPRCVYLLRRAVQLSLCLAEKYKYRSIAIPAISSGVFGFPLGRCVETIVSAIKENFQFKKDGHCLKEIYLVDVSEKTVEAFAEAVKTVFKATLPDTAAPPGLPPAAAGPGKTSWEKGSLVSPGGLQMLLVKEGVQNAKTDVVVNSVPLDLVLSRGPLSKSLLEKAGPELQEELDTVGQGVAVSMGTVLKTSSWNLDCRYVLHVVAPEWRNGSTSSLKIMEDIIRECMEITESLSLKSIAFPAIGTGNLGFPKNIFAELIISEVFKFSSKNQLKTLQEVHFLLHPSDHENIQAFSDEFARRANGNLVSDKIPKAKDTQGFYGTVSSPDSGVYEMKIGSIIFQVASGDITKEEADVIVNSTSNSFNLKAGVSKAILECAGQNVERECSQQAQQRKNDYIITGGGFLRCKNIIHVIGGNDVKSSVSSVLQECEKKNYSSICLPAIGTGNAKQHPDKVAEAIIDAIEDFVQKGSAQSVKKVKVVIFLPQVLDVFYANMKKREGTQLSSQQSVMSKLASFLGFSKQSPQKKNHLVLEKKTESATFRVCGENVTCVEYAISWLQDLIEKEQCPYTSEDECIKDFDEKEYQELNELQKKLNINISLDHKRPLIKVLGISRDVMQARDEIEAMIKRVRLAKEQESRADCISEFIEWQYNDNNTSHCFNKMTNLKLEDARREKKKTVDVKINHRHYTVNLNTYTATDTKGHSLSVQRLTKSKVDIPAHWSDMKQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
The following text describes a protein:
Function:
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Melanosome.
Sequence:
MSQAAILRKKTRKDFIPYFLGFVIFLYGTFHLISFTAKTAEFAPTVRVRRALENETECISPQASEFPDGFFTVQERKDGGLVIYFMIIFYMLLAVAIVCDDYFLPSLEVISERLGLSQDVAGATFMAAGSSAPELVTAFLGVFVTKGDIGVSTIVGSAVYNLLGICAACGILASVARRLTCWPLFRDCLAYGISVAAVIGIISDNKVYWYEAACLLLVYGVYIVVLCFDLRISEFVLRKLSPCCTCLSSGSADKMETQPLTGWNDDTRLRICGRSRTDSGIFHDDSGYSHLSLSLHGLNEISDAEQKSVFSVPESDLKRILWVLSLPVIVLLFLTVPDCRRRFWKQWFMITFFMSAVWISAFTYVLVWMVTVVGETLGIPDTVMGLTLLAAGTSIPDTVASVMVAREGKADMAMSNIVGSNVFDMLCLGLPWFIKTVFVDTINPVEVNSSGLVFVSCTLLLSIVFLFVAVHINGWKLDWKLGLVSLICYILFATLSILYELGIIGNNPIRLCSD
The following text describes a protein:
Function:
In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Note=Localizes around oocytes in the proximal region of the germline.
Sequence:
MGPQLATVSLLLLTFFSNSIQYPHSPAATECPAYFNGNIAGNACSREYSICVNGVRQAATCSDDSVFYEDECVPVDESPECRVDENTEEDDTPYAEFDCTSKQDGIYSIGCSNQFISCVAGGAYMAKCPDSLVFNERTQDCRESCDEVKQDTTTAPQVYEDGEEGYGEASGEIAGDYERQPSNEQPDSIDFDCNGLEDGNYADGCNDVFYSCSNNMVFQRYCPPGTVFNINQQSCDFQCTTDDPTTTVSYSTSTITTPQEDDSEYSSTTSADVISTTTTPSIDAIETTTTGFDAVTTTTTTQTPFVCQEGQVNSFGMCSSRFNRCQNNSVRSKQCPVNTLFESSLVMCVFDLPQCQPITVPAAPAYNSYGPPSDTIVSPFDENVRLKPKFDRRRKYHHGKPSYGPVNGNSYLENPFFIPRHRGGSHRDHRRYGYGPAIDSPFSTAFRGRAALSDQFKDYRRARMGKIQGDARKVDGNKRFLIDDEFEGPNAKFVESNIEQVFPKNRHSKKQLGPHEDPDGYDDEKTFDAKDLFGATRRKRSAYYGTEQSVYGQQSAQISARQAQVNKDCQQYTTPTFLTFGDCFDQFIFCSGNGINRMAACPIGETFDKTLRSCSETCGVSTTIVAVTIGTQTSDDLSAPSEYIENDGVTTQSTWNDQPSTTQAPNSYESYTTQYSSNDVPSTSAAPIGDRCSLDASGLFSLGCSQKYIQCSNGAAIVRRCGESLYFNEATQECTYRDEVPECGSQGSTSSPVITTPGQDQSSNYYGIPSDDVPSTTQTPVGDRCAYVASGLFDLGCSQKYIQCSDSAASVRECEGSLYFDERSQSCRFRDEVFKCQTADVSSSSTVPYLDFTTTPASPSEDEPTTYEPSVAPYIPSVTVNPVDTCTSLSDGTHGTGCSSFYFVCSHGRLISSGNCQLGEGYDPSVQGCRTFSEIPARACDEQEVTTDAGLVQLMPYKTLEEVLTTTEAATTVANDGPTDTYITGSTKYSTTDSGEYTIPYGDETTSTRSYDRADNDSEDEEEDDVEHDQKCTVGSRTPVGFCVRTYLECTDAGNVEKLCRIGKLFDSHSNRCVPRIGCGKEAIRDAIKDMIATTPAPAQPKQFEGRCAHVDGEAVFSIGVCSSKYLRCSYGASKLQQCSEDRVFSNDKLECIVRESVSACTVPKNPSIKKYYTSNDQSAFCDGKEDGLYRNERDCSAILQCFGGELFEHPSCQSSLAFNQLTGKCDYPQKVSGCENHGQTNGECSEHGSFIADANNCEVFYRCVWGRKVVMTCPSGTVFNPLLSVCDWPSAVPSCSGQASDSNSSYGSSTYNDDKSGY
The following text describes a protein:
Function:
Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MIFSTFSPLWNVNTPLLPALREEKTDHCPVMEEDAFPRGGTVQKTDTADRTTQKRRDAHPQDNLFMPRPDEKKKGKKQRKKKKAKNTKQEPTSELGEEEEGEGSLPNLVTSVQVLSYKKLVTGMPILGCVKEVSDCDLTVSLPDGLIGFAQITRISDTLTRILQEYADGSGHTDEDFPTLPKLYQAGAMVRCVIAEVVTSKSGHPRILLSLNPRDVNQGLQGTTLKPGMVLSGCVASIEDHGYTVDLGVKGLRAFLNRAETQEFLQSRQMAAPMRLAQPLLCLVRSVVSGGRSVNLTISPTLLQKAVAKEDLDLTLDSLTPGTLVEVTVTSVQNHGILAEFLGFTGSVSRVHLPTKRAELYRKGQRVKACILYIHPTTKTVGLSFQSRLWDGRTLVDVQELPAIGTVYKKAPVVHVWSGIGVTMKLSAETPGFAAVSQLSDQPVESIENTFKPGTQHSCRVINCSPLDGQAIVSLKKSVIEQPFLRLQDLKPGQVVEGKITSVQSYGITVSLSNYVRGVVSKIHLADIILKNPAKKFNEGDMIKCRVLNVATAGRQLALTHKRTLLTSKLPIMASYQAAKPGTWAHGFVLSVQDFGCIVMFYNNVKGLLPKREMTQEAQEDPRKMFYKGQVVKCRVMSCNPALEKLTVSLKPEKSGTPVAADFEVGKMVNVEVTEVKPDSLGVKVQGSDTPGFLPMMHLSDHQENCSLLLSRCSVGDVIQDAMYCCSRATGSMVTLKPSLKKAVTSGQVVEMFSDLRTDRVLRGWVRTVKPFGVFVEFPGGWVGLAPKAAVSDRFIEDCTSLFEEGQSVVAKVTEVDGEKQRFLVSLKPSDCPLAGEGSTAVESLGSLLAEREKAAGQLTAGKGADLSRQHGKVLSATVTNIQDAGMVLSIPDLQDLTAVASKTHCQGTNLNVGDSTSVRILHLDIPNNIAEVSLRPDLLEQATEGKKIKMKKGGEFSCTILDAKAKYLLVGINGSGALAYVTRKWHPNHGSNVGMGDAQIGERSKIRVVRITQSGSVIAMPAGKKTEGKKDGKEGTEHKAEKRREEKNRKRKRDESETREETEADGQNQAEQLQLGAIVNVVVVATARDHLEVKITGQGHRQEGIVHISEVKDDVSEGEAPMAKFLVGSIVPGRVIGISHKKVKSLKSLPFSRPGFEEVVYDVSLRESVVKAEANFEKYLLPDQKLRTDVYKEDQKVMFYLQSVQDSHVVASVSPGVLGKLDLLSCSDNVEDLKNPSAMFKPKCAYLGTITSIDRESSTLHLSRLEKATKLAPGLVVNAQVAKKVPGKLVLSLPFGGKGFANLTDLSDSYSSNPLSVFKVNQLLRCCVLECSSKRHVRVSLRPSKIGGKVRKINDPDYETVEDIVDGDIVRGYVEDCNKHGVFAALSHKVKGRVQYKHATSYFVRKQDELKKFFPVGKLVTAKVLEVSYKSSHLELSLLEKDTGAPDPLPNTCGYPLRTPKDQKEKKRKERGKEKGEKGGKKRKVERESDADDSGVEVVGMKSTDEEEESVPIKSSGQGQTSSSEPRLTLTGGFSWGDELAVSKVTPQDSESEEEDDTEAEVSQPPKKKSKKEREEERKANDKELYKAELALLDEDRPPQSADDFDRLVLSSPDSSILWLRYMAFHLHSTEIDKARTVAERALKTISFREEKEKLNVWVALMNLENMYGTEESLMTVFQRALQHNEALTIFKQLVNIYKRTGKTEEADQLYGTMVKRFRGNKDVWIDYGQFLMENKRAEAAHSLMQRSFKSLDKQDHVQVISRFAVMEFKLGDVERGRTMFENILSNYPKQVSIWSVYLEMLIKTGDLDQVRLAFDRVTALHLSTKNMKGFFKRYLEFEKKHGDDDTVSAVKRKAMEYVEARVGDVGTT
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MSLVAYDSEEEEQTSLVNENNDIKGRSEEPHWKIPNSPKAEVDTELEKKIKQFIKLKAKGIHFHTRLSENENFRNPKLLDNLQDFLDIKEPRGTMISKDMWDPTDFHKNVYASALSKSQDEMIARRENYQKHDRTEIKFQTSQHPK
The following text describes a protein:
Function:
Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.
Sequence:
MAFANLQKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEISASFGVQQLPVEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVITCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTIQVITQGTSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGECLLAVALAGAPYQAVGLVQGTTPVLQGLNGAVFRPEVPLRRDLPLLLFRTQTSDPAMLPTMIGLLAEAGVRLLSYQTSLVSDGETWHVMGISSLLPSLEAWKQHVTEAFQFHF
The following text describes a protein:
Function:
Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.
Subcellular Localization:
Nucleus.
Sequence:
MDLGTAESTRCTDPPAGKPPMAAKRKGGLKLNAICAKLSRQVVVEKGAEAGSQAEGSPLHPRDKERSGPESGVSRAPRSEEDKRRAVIEKWVNGEYCEDPAPTPVLGRIARDQELPPEGVYMVQPQGCSDEEDHAEEPSKDNSVLEEKESDGTASKDDSGPSTRQASGETSSLRDYAASTMTEFLGMFGYDDQNTRDELAKKISFEKPHAGSTPEVAASSMLPSSEDTLSKRARFSKYEEYIRKLKAGEQLPWPAHGSKAEDRAGKEVVGPLPSLRLPSNTAHLETKATILPLPSHSSVQMQNLVARASKYDFFIHKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYDVRGIQKPGPTKIPPAPSLVPTPLTNVPSAPSTPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKYIARFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVGCNKVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKKFYKYEECKYEGCMYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPASLLGAKDTEHEESSNDDLVDFSALSSKNSSLSASPTSQQSSASLAAAAAATTAEAIPSATKPPNSKMAGLLPQGLSGSIPLALALSNSGLPTTTPYFPLLPNRGSASLPVGSPGLLGSMSSGATTSATPDMPALMASRAGDSAPTAATSLSVPPASIIERISASKGLISPMMARLAAAALKPSATFDPGSGQQPTPTKFPQAQVKQEPDSAGTPGPHEASQDRSLDLTVKDPSNESNGHAVSANSSLLSSLMNKMSQGNPSLESFLSIKTEAEGSPAGEPSPFLGKAVKALVQEKLSEPWKVYLRRFGTKDFCDAQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGTAKGTPEASFPTSAAETKPPLAPSSLPAPPGTMVAGSSLEGPAPSPVSVPSTPTLLAWKQLASTIPQMPQIPSSVPHLPTSPLATTSLESAKPQVKPGFLQFQDNDPCLATDCKYASKFHFHCLFGNCKYVCKTSGKAESHCLDHINPSNSLVNVRDQFAYYSLQCLCPNQHCEFRMRGHYHCLRTGCYFVTNITTKLPWHIKKHEKAERRAANGFKYFTKREECGRLGCKYNQVNSHFHCIREGCQFSFLLKHQMTSHARKHMRRMLGKNFDRVPPSQGPPSLMDAETDEGMDYTGCSPGAASSESSTMDRSCSSTPVGNESTAAGNTISMPTASGAKKRFWIIEDMSPFGKRRKTASSRKMLDEGMMLEGFRRFDLYEDCKDTACQFSLKVTHYHCTRENCGYKFCGRTHMYKHAQHHDRVDNLVLDDFKRFKASLSCHFADCPFSGTSTHFHCLRCRFRCTDSTKVTAHRKHHGKQDVISAAGFCQFSSSADCAVPDCKYKLKCSHFHCTYPGCRHTVVGMSQMDSHKRKHEKQERGEPPAASPGAPVNLDGSLTLAAEQGSLLFLQTAAAGLGLLGDTGDPGPPVTASGTRDGPAAPTPAAAATTTTTTTATATATAGESSQEDDEELELPEEEAEDDDEDDDEEDDDDEDDDDDDDDEDLRTDSEESLPEAAGEAGARTPLAALGGPGPAPTAAS
The following text describes a protein:
Function:
Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MNWHMIISALIVVVLKIVGMTLFLLYFPQIFGENNAIFIPTESSATVPQILGNGTVSFTPTESYGTVCPKGWDFHQGRCFFLSKSESSWNKSMNFCKEKGSTLAIVNTPEKLKFLQDITGAEKYFIGLLYQPVEKTWHWINNAKFNGNITNQGQNFHCVTIGLTKTYDAVSCDITYRWICEKKAQ
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Sequence:
MAATQEVPPPALGLHFLYPLEETMPPRVKMEDPGPPCPEAGWEWDAPGKPPLVVQAGTISDLLRWATPPQVRSDPIPQLWEVQCQEMVQSLRTPADVVPPPVPVPPPAPGWGNLQLPELAPVDDIEAYLSSFERAAETCQWPRGEWMSRLMPALSGKAHQPHNGLDARSSRSEHRKSKSSGLRGETGASVEMQRQRFRQFRYQDSEGPREACWRLRELCRRWLKPESRTKEQILELLILEQFLTILPQEIQSWVWERGPETCAQAVALVEGYQMGRREAGMWEQQVTVRVKVEQVSPQEMVLPSVPWEPSVPLMPHPECVSSGEVTLHQPVPGPLLKMPCIPKQEPQGLHEAGPLMVNGSREENPLQSGSMPVGILPGNSQENLLAENRGEHAGQQCQSQVVRQKCGETGESPAAHSNPIGSLHPPGKALHRCSECGKTFSRNSHLLTHQRIHTGEKPHQCPQCGKRFSHTSQLTRHQRTHASERPFRCSQCSRSFYQSSELTRHRLSHARDRPYGCSQCGKKFRWSSDLIRHQITHTGERPYKCPECGKKFGQNSHLVRHRRTHTT
The following text describes a protein:
Function:
Plays a role in the inhibition of host innate immunity by exploiting host DDB1-cullin RING ubiquitin ligases (CRLs). Mechanistically, recruits host DDB1 via a DCAF-like interaction motif to antagonize IFN signaling by STAT2 degradation.
Sequence:
MYGVLAHYYSFISSPSVMVNFKHHNAVQLLCARTRDGTAGWERLTHHASYHANYGAYAVLMATSQRKSLVLHRYSAVTAVALQLMPVEMLRRLDQSDWVRGAWIVSETFPTSDPKGFWSDDDSPMGGSED
The following text describes a protein:
Function:
Putative Notch ligand involved in the mediation of Notch signaling.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLSDKKAALLLVTAITALKLEEMNAYRRNFDARQSSNSNIPLWKQRACEKSQKQRQNAHYVCDEKGDFKCLPGWQGDLCQVPMCRRGCDPMNGYCQRPGECRCRIGYSGELCDKCIPLPGCQHGGCTKPFECICKPGWAGLFCTEPSCRTGCHSTRGYCEAPGECRCRIGYAGRTCSECATMPGCQHGTCNKPLECLCLPGYTGLLCQTPICDPDCSKQHGYCRKPGECRCKVGWTGSQCDKCFPYPGCANGDCEAPWECNCHPGWGGMLCDEKLTYCVEHPDTCENGGKCTSLSREDGSYQCQCRQGFLGKNCEIRDDFLLTSEAPPRITPPTPAELVLELDGELDQNGQQDIGAGVPDDSEPGGGLVGEKLPAGNEPERRKNDTVANVATAGTGAGAGPMNSLPGNSNATRTTLVVATETGSDNATNEALSAVTTRRATPIPLTSGEKTVKGNATSVSVATGPQPRPPLPIVASQEQTIANLAPAGTVTVTATTAPTATTAATSVTSHKDKPNVADEEEDEDDDDDEEDEDGEYDEEEDEDEDDEEDDSDQLIPNII
The following text describes a protein:
Function:
Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.
Subcellular Localization:
Nucleus.
Sequence:
MESWSYLSGGKGFISEESVSVNDGMGRAKNGLMGWELKTPNSYVMCSSQEGSTNNQGFPELGSQNLMRKTMFSDQSIFGSVAASPSAYSGEDKSKSSSKLSSSVVESNSRDSSLIDLKLGRFLDQIDANVYKSPKIMPNVSSAESIVPAKRMRAGGASSHPFCQVQGCGKDLSSCKDYHKRHKVCEVHSKTAKVIVNGIEQRFCQQCSRFHLLAEFDDGKRSCRKRLAGHNERRRKPHTGNRFRGTLATSSFACQDILGVRFLHQPKFEMHDWYKNVKVEDGVERSPQLVMPFSNGQLQPKSVFTSYHAKKQCQPLHDEGQPAVTTSRINESTISSLHDIRGSDFVSPSLFHTTSTGSEVLHVLDTSSTIHGLSGISNSSNALSLLSSQSRGSSNHSTVFRAAHPLISPSNNSRYSVTQASKEVLGLSPQDSAGRLSNTFNSSGVNSAEGGLDQILFPSSTCGVNGIIQGPNFVNHKDQLSCEDGPTIDLLQLSSQLQRVEHQRLSMQAKQGSNTFPGLRIT