lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Essential for the structural integrity of the CSN holocomplex.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAPSSSSGLTFKLHPLVMLNISDHFTRVKTQLNPPSSSCAAGNTPAAVGATFPQNFRVYGCVIGAQRGRTVEIFNSFELVFDPTTDSLDRAFLEKKQELYQKVFPGFYILGWYSTGSEANESDMHIHKALMDINESPVYVLLNPAINHAQKDLPVTIYESEFHVIDGIPQSIFVDASYTIETVEAERISVDHVAHLKPSDGGSAATQLAAHLTGIHSAIKMLNSRIRVLFQYLVAMQKGDIPCDNSLLRQAAGLLRSLPAAHSEKFNDNFLMEYNDKLLMSYLAMITNCTSNMNEVVDKVKTAYAKKIRTGGSRIPFM
The following text describes a protein:
Function:
May play a role in photoreceptor function.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cell projection, cilium. Note=In the retinal photoreceptor cells, localizes at the connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment.
Sequence:
MEREPRARVALVPERCGRGPSSRHRRPGLLLPGLWLLLLAGPASCAPDDLSLAQHSHPVRPSDFLPERSILHSAAQVTLSETVPRSQPSISALVLSSPSATAFDTAFLSQRQQTQSTAEPSFFEANYGSVTSNEVALDDEEMDNFLPDAHWTSSRGVSPMRYITPSPPEPPQEMLEPGTTPSLPTISLPDEVLSGCQNTVQQATVYVEPSTYFGTSWSAFLTSEGIIPTPSRNSVLHPIEIHSQLSSKALPETVASVTEGAENLLFSSRISVSQPSGNGMTQQPSVPLWEVSQPLVGVLATSSDRYPNETTAWIEHPEEAIALRAHPGITTSPTDPTFSSQPSALFSTPLSSVSFATQLPGVSEDSFLSSEARGALESWHSSPVPSFTDHPYVLSPESSLRPHTGCVSCVVSSFQQELARSLTEKDMGSGDRLETLSTASVEASHVSPLSSVGTDLSELEEPQEFNTLFPSRPVFSFSSRPVGLWKASMDVSPEVDVSGIAITQVYPSHGRLSTPSSLDSTFGFSVTSDLVMSSSMIHLLSSVIPSTHFDSSFSLTANQNSPSFPAGKPSLLTSPSLVPSAQSSAFSHGAPTSSLELQSGSRLDFTSGFYSTPPLDFSTPAPSRSDELAFPSLMSSDPSTFFSQTFSTMAETFSLSNSMNLQSPQLSVLNPTSLEPSQPQSSADLLLNTVTVLPSPPERPPLSSSPSDSLEFTEVSRVSLRESHVHLTSAFSETTSAFEFSPIPHESTISTLVPSSSEPSLGIYAAGTHLTSLPTTVFHLTPILTESSPFSTLTPSDGSVRVTDHHTPVLPTPSSVIPSSTESISDPYLSASSSLVSEVSPSPPPTKPVMGSSLTSTDFPPSTSPELSTSLELSMPSASTAPGDTVDSALNSEPMSQNPQGNSVPPPQPSLGPATTSTLEATVGTPALATAKPPYVCDITVPDVYLITTVLARRAVQEYIITSIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRGQTPLILSVKPSFLVPDPRFQVQTVLQFVPPSVDTGFCNFTQSIEKGLVTALFEVRKHQGTYNLTVQIVNVTIASSRVAPRRGPVNIIFAVKGSQGFLNGSEVSDLLRNLTVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVVEKQLHNEVFPAEMERKLAQLLSEVPTRRRVWRRATVAAGNSVVQVVNVSRLEGDDNPVQLIYFVENQDGERLSAVKSSDLINKVDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVVVGVVIPVLVVTVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPVKDHTTPSENGDVPSPKSKLPSKNIRLRGRVSPSDADSTVSEESSERDAGEKAPAAAPENKALRAPQSGAPLPSSGNEQHSSASIFEHVDRVSRTSEASRRVPSKIQLIAMQPIPAPPAQHPVLADRVAETNKINKEIQSALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPAASVPSVFIEPRKSSRMKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYKRPPGVHNSAYIGCPSDPDLPADVQTPSSTELGRYPGLPFSASQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPTNAMGAGTGVPASLPVNSTPSREERRATQWGSFYSPAQTANNPCSRYEDYGMTPPSGPLPSRPSFGPGLLPSSELVPPEPPQPQSSTDAPYAARGIYSEEMPSVARPRPVGGTTGSQIQHLTQVGIASRIGAQPVEIPAGRGSQYGGPGWPVYGEEEAGRREATHMLGHQEYSSSPLFQVPRTSGREPSAPPGNLAHRGLQGPGLGYPTSSTEDLQPGHSSASLIKAIREELLRLSQKQGSVQNFHS
The following text describes a protein:
Function:
Transcription factor involved in iron metabolism, oxidative stress, surface adhesion, hyphal development and virulence. Functions as a negative regulator of MRS4 expression through the CACCC AFT-type sequence in a gene dose-dependent fashion. Acts as a repressor in flocculation, plastic adhesion, and surface hydrophobicity.
Subcellular Localization:
Nucleus.
Sequence:
MTDRVTHRVSLDDLNLEKQKFDSKDDIKPWLQDNLQSTKGINVVIERSDTSKIIFKCKNKEKKTKIVESKKTASKTMIRKHTSCPFKIRANYSVRNKVWTLSIVSDEHDHVVDLPRSFVGKNLISNTIPGSSLNVLDSVAPRSNKKGIKPTSEIANTPSVTSYSPSCAVKRNEDVDAPKISSKKARNLTKKPSTQSTRSSSSSDGSSIVSFGSLTSQSSSTSLPENYKGQVPTSMDSMVVEESLTGKSLKPAASHPVKRKNMKANTMKKSKKLKQNPIVVSPIEEDSNLNSFDDANIDLQRQQSLQSPLSHLVQNQDPISLEQNPQLHTVYPQPRHSKQSSSLLKKNQQQDRIPDNMPLQPQENNRTLQNFPLNQFNANEILQNVQQVVRETVKSEILDSPNIDNTYKTDMMDSFVSSVILDYKDYLSSQFLFSLKQNLYDRREATHTNVDLEQNGSNENLFDEQPQHKHNHQHNENQFSYQSQIQNQRQNQNQNQGQNQNQNQSQSQTPGQNSNQNDSQTQIPLQSQTPQDRKSAMQQNWLPGSTPGVGGLIRLSPLLNDNDNNEYAAVAAAAVVGSTPGNPNGNSLENFTHLPGINSSTLNYLMQLPHPSANPNSGGVSSSQPASLMSLQGHQGLLQQQQQQQPMFSMQNSGQQLPPLSSIPKLPSSNNANVNLNSSSTLPLPLNNTGPTLNPSSLLKSTSRNSTNSGNINVNNINNSNNNSNSAFNSVFLNSSITTNPAFIFNSQGNPTNSNQSMVNSIMTTNSNKDGTATSNNNSSGNTSNNLLNDMPNYGPGW
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHMKQNAHGEDDSHAPSSSDVGVSVIVKNVRNIDSSEGGEKDGHNPTGNGLHNGFLTASSLDSYSKDGAKSLKGDVPASEVTLKDSTFSQFSPISSAEEFDDDEKIEVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKLKALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKVRKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSKLSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRAADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVMASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIKPVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFALEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTVTKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECNEVFQDETSLATHFQQAADTSGQKTCTICQMLLPNQCSYASHQRIHQHKSPYTCPECGAICRSVHFQTHVTKNCLHYTRRVGFRCVHCNVVYSDVAALKSHIQGSHCEVFYKCPICPMAFKSAPSTHSHAYTQHPGIKIGEPKIIYKCSMCDTVFTLQTLLYRHFDQHIENQKVSVFKCPDCSLLYAQKQLMMDHIKSMHGTLKSIEGPPNLGINLPLSIKPATQNSANQNKEDTKSMNGKEKLEKKSPSPVKKSMETKKVASPGWTCWECDCLFMQRDVYISHVRKEHGKQMKKHPCRQCDKSFSSSHSLCRHNRIKHKGIRKVYACSHCPDSRRTFTKRLMLEKHVQLMHGIKDPDLKEMTDATNEEETEIKEDTKVPSPKRKLEEPVLEFRPPRGAITQPLKKLKINVFKVHKCAVCGFTTENLLQFHEHIPQHKSDGSSYQCRECGLCYTSHVSLSRHLFIVHKLKEPQPVSKQNGAGEDNQQENKPSHEDESPDGAVSDRKCKVCAKTFETEAALNTHMRTHGMAFIKSKRMSSAEK
The following text describes a protein:
Function:
Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Binds to RNA. Required for female germline development, cell viability during eye development and for survival of dividing cells and epithelial cells during early wing disk development.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Nucleus, nucleolus.
Sequence:
MPDSSDDESQAPSGPVENAWAMKIPEFKPEDNPHGLLEESSFATLFPQYREQYLRQVWPLVQKTLKEHHINAELDVVEGSMTVRTTQLDVVEGCMTVRTTRKTWDPYIIIKARDMIKLMSRSVPFEQAKRVLNDDVGCDIIKIGKITRNKEKFVKRRQRLIGPNGCTLKSIELLTNCYVLVQGQTVSALGPYKGLQQVRKIVEDTMKNMHPIYNIKALMIKKELAKDPKLKNENWDRFLPRFVNKNISKRKQPKKKKEKKPYTPFPPPQTESKIDKELASGEYFLNKEQKRQKKQKEKNEKHAAAAKKREEKRNEAFVPPEEPSTSKQSPNVNTKVDIASLKEKIMKARKGAKMFNKPTKTNPRKESPLRIRSHLGYFINMISSGDGDTLPALQAVPVFFFLIINLMMCYFVYAVFDPSEQPGANRMMFFLIILALVMVVVLLIIIVSVIAHAYSTHQKLHDGIVTAMNHYLNSTTYKSQIDRLQIEMQCCGSKKYDEWYTIKWQDQTLEKETGSAADGNTPFSCCSMKSLSPCIHHNIEVTGKAYLYTPEFNLSISTRGCYEMIREKKQTVGWIIVGNLILYIILEVVTLILFSSFLHRLVVRELHWQS
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MSSYEDSDVEITEELGVEQFEENAEQTEETPAENNEAEAAPSKPVKAKRVIRNPQPKLNAERLKGPRGLAALESHFDRVKYKGKGYEEQDLGVILKTYEYWCHRLFPKYPFDECIAKIEALGSKKPVVTHIKRIRYDLLVEDPPIINNDDSDPEPEAPAESQFDAVAGLPGITQPNDEPELTEEQLEMIKINRERAARIRKERMTRGINESQGSEIVATTASEGNDLPMASQDEFPDDLEMEEIGQSVDALPMPSEDDFPSDQEEELTRQEPIISSAENAHPTQDDLFEKENEQNFEENSSQSQVGSQPASENLLEDQDLNEPETA
The following text describes a protein:
Function:
Involved in pilus assembly, twitching motility and adhesion to host cells. Primes type IV pili (T4P) assembly and is required for inclusion of minor pilins PilV, PilW and PilX to the surface pili (By similarity). Stabilizes assembled pilus fibers likely by antagonizing retraction mediated by PilT. Calcium-binding and calcium release by PilY1 seem to be essential for twitching motility and for regulation of pilus retraction dynamics of PilT. Adhesin for human tissue specifically recognizing a host receptor localized or enriched on basolateral epithelial cell surfaces. Binds host integrins in an calcium-dependent manner in vitro and this interaction may be employed by the bacterium to mediate host epithelial cell binding in vivo.
Miscellaneous:
MISCELLANEOUS: Residues 600-608 comprise a calcium-binding site which together with the other one (residues 851-859) seems important for interaction with integrins of the host.
Subcellular Localization:
Fimbrium. Membrane. Cytoplasm, cytosol. Note=Colocalizes with the T4P fraction when surface pili are present. Sheared surface fraction when PilV, PilW and PilX are also present (By similarity).
Sequence:
MKSALHQIGKTSLAAALSGAVLLSAQTTHAAALSVSQQPLMLIQGVAPNMLVTLDDSGSMAYAYAPDSLVNSRNNVYFASNSYNPMYFDPNTQYKLPKKVTLSNGQIQVQDYSKPSFTAAWRNGFTQEGRVNLSRDYRPTVQYQGGSGAGTESSIDWYGAPAFYYQYSGGRGCSLTTSSCYTRVEISGAAQQQNFANWYSFYRTRALATQTAANLAFYSLPENARISWQLLNSSSCLIGSGSSNCYNNYLRDFTGQHRVNFFNWLENLSVGGGTPLRQAMTRAGEFLKKTGVNGPYAYRPGTQTSPEYSCRGSYHILMTDGLWNNDSASVGNADSTSRSLPDGKSYSSQTPYRDAASNTLADQAFHYWATDARPDIDDNIKPYIPYPDQANPSAEYWNPRNDPATWQHMVTYTLGLGLTTSLTSPKWEGSTYSGGYDEIAAGRLSWPNASNNHSNNVYDLWHAAVNSRGEFFSADSPDQLVAAFQDILNRISGKDLPASRPAISSSLQEDDTGDKLTRFAYQTSFASDKNWAGDLTRYSLTTQDKATVQTKLWSAQSILDAMPNGGAGRKIMMAGSGTSGLKEFTWGSLSADQQRQLNRDPDRNDVADTKGQDRVAFLRGDRSKENSDNFRTRNSILGDIINSSPATVGKAQYLTYLAQPIEPSGNYSTFAEAQKTRAPRVYVGANDGMLHGFDTDGNETFAFIPSAVFEKLHKLTARGYQGGAHQFYVDGSPVVADAFFGGAWHTVLIGSLRAGGKGLFALDVTDPANIKLLWEIGVDQEPDLGYSFPKPTVARLHNGKWAVVTGNGYSSLNDKAALLIIDLETGAITRKLEVTGRTGVPNGLSSPRLADNNSDGVADYAYAGDLQGNLWRFDLIAGKVNQDDPFSRANDGPAVASSFRVSFGGQPLYSAVDSAGAAQAITAAPSLVRHPTRKGYIVIFGTGKYFENADARADTSRAQTLYGIWDQQTKGEAAGSTPRLTRGNLQQQTLDLQADSTFASTARTIRIASQNPVNWLNNDGSTKQSGWYLDFMVNGTLKGEMLIEDMIAIGQVVLLQTITPNDDPCADGASNWTYGLDPYTGGRTSFTVFDLARQGVVDSKSDYSYNKQNVAVSGTEQKGLGGLTLSTNEQGNPEVCSSGECLTVNPGPNTRGRQNWRPIEGKN
The following text describes a protein:
Function:
Transcription factor. Essential protein involved in iron uptake responses. Regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation. Confers enhanced iron mobilization responses at low iron supply.
Subcellular Localization:
Nucleus.
Sequence:
MEGRVNALSNINDLELHNFLVDPNFDQFINLIRGDHQTIDENPVLDFDLGPLQNSPCFIDENQFIPTPVDDLFDELPDLDSNVAESFRSFDGDSVRAGGEEDEEDYNDGDDSSATTTNNDGTRKTKTDRSRTLISERRRRGRMKDKLYALRSLVPNITKMDKASIVGDAVLYVQELQSQAKKLKSDIAGLEASLNSTGGYQEHAPDAQKTQPFRGINPPASKKIIQMDVIQVEEKGFYVRLVCNKGEGVAPSLYKSLESLTSFQVQNSNLSSPSPDTYLLTYTLDGTCFEQSLNLPNLKLWITGSLLNQGFEFIKSFT
The following text describes a protein:
Function:
Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor (CPSF).
Subcellular Localization:
Nucleus.
Sequence:
MPFPLASQGSQQSQKTYGITSPISLATPKDTDCTLTQKLIETLKPYGVFEEEDELQHRILSLGKLNNLVKEWIREISELKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVDRSDLFSSFYEKLKQQEEVKDLRSVEEAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDSFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRAVMVEEFKQGLAITDEILLLKAEWSKLFDAPNFFQKYKYVFYNLLAMFAWGEIINKNKKRCYTLKKKKK
The following text describes a protein:
Function:
Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, U-body. Nucleus speckle. Nucleus, Cajal body. Note=Mostly localized to the nuclear periphery. In Malpighian tubule cells, detected in nuclear foci that include the Cajal bodies. Accumulates in the U bodies of the follicle and nurse cells.
Sequence:
MESSFQELYKKGLDIGEQQKQRQKELLKQQKLRRQQEQDDYRPLQNQEKPVPRKKSGKRSGHQKGIPYRPQLSEWLRHKPDDLNEWLLVPCPVGKRCLVVASKGITKAYSKGGWMFVNFRSSLPGDWQLQKGETILDCVYVEDADTFYVLDAISFGLQEVQECEASFRFYWLRARFEEHDYDKISENNEKKFKLLDHFDFEDPSAVEQALHKYPFFPENKPDLDGFLFYHKEASYVCRETPLVCWLFPFMMEDVLGLPVNKCYKAPEDYQPSHVLQYMDAFEQKLAEHRRTLKEQKKKVNEQKEDPHTMEAEEDVESDEYDSLKRVLDQQRRLELGEFDMDCAEPPSADGC
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
LIVVLDMDECLIHSQFLSDQTHDKYRQDEERPTGKSPFHYSNEEAESIITTSCESFRISLPDGDLVHINKRPNLDLFLKEITSKFETYIFTAAMEVYASPVLDKLDPEGDFFRGRFYREHCLFHEDLGVYAKDLCDRRVVLVDNNPLSFLPNPSNGILVSSFYDDPKDDTLEAVMELLNELDESEDVRPILHEKFGLKDALSDVVKGTSGWR
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MTRQTTSQTCLICGDSADSLHFGALSCRACAAFFRRKVAGRRNIFRRCDRQCKVDTGMRKLCASCRYDKCLKVGMRESAVLSRLAKKNQNYKKSIVGSPDAYEPSTSTSDSVLENLQSAYHKLEETRKRVFNISETHVSQCCNYKRMNDVFFEDIKLVMEHLLETFKKSDISQEQEKLLCVHFMVPFILFEGGYKSTNSDLFYLPSGDFIDENRIEEYYSNPDDQNDNSAKSAAEVFRPYWKLNKQTLKTHLDDVQLDLPEFLFITALIYFDDGLLDQNEECIEVCKQMKAKIIEELTDYEKNVRINEDHSYRVGQIIMVLHGIQRTMNMIHETKEISLVYNVYDMHSSIFGNMAE
The following text describes a protein:
Function:
Mediates phosphorylation of MECP2. May regulate ciliogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
Sequence:
MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSTKRKPYHVESSTLSNRSQSTKGGALQTHHRSNSKDIQNLSVGLPRAEEGLPANESFLNGNLAGATLSPMHTKTYQASTQPGSSSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSSTRSQQNRHSFMESSQSKAGTLQPSEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQITETNTSRYFPSSCLDLNSPTSPTPTRHTDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGIDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARPSVKESSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSDSSSGTNHSKRQPGFDPWKSPENISHSDQLKEKEKQGFFRSMKKKKKKTQTVPNTDGPDLLTLQKAIHSSSTASSRPKEWRPEKLSDLQTQIPPPTGFLALSPRGPTGCINVELPRLLWRDKREDQSPNLPLTSIC
The following text describes a protein:
Function:
Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain.
Miscellaneous:
MISCELLANEOUS: Present with 1560 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MIKRSLASLVRVSSVMGRRYMIAAAGGERARFCPAVTNKKNHTVNTFQKRFVESSTDGQVVPQEVLNLPLEKYHEEADDYLDHLLDSLEELSEAHPDCIPDVELSHGVMTLEIPAFGTYVINKQPPNKQIWLASPLSGPNRFDLLNGEWVSLRNGTKLTDILTEEVEKAISKSQ
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 2791 (Um2791) in the 21S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
Subcellular Localization:
Mitochondrion.
Sequence:
MILVYNRIRSIISSSLGRIHVRYNSNSQNRWLNRQLKDPYTKEAKVQNLRSRAAFKLMQIDDKYRLFSKNRTDQRILDLGYAPGAWSQVARQRSSPNSMILGVDILPCEPPHGVNSIQANILAKRTHDLIRLFFSKHFQLNRHDDLHKDHGYFQNMLEEELTHVKDTELYREIFTSDDIYETPNTNSTLIEREKFPVDVIISDMYEPWPQTTGFWNNITNQAYFRMANTSGVSIRDHYQSIDLCDAALVTAIDLLRPLGSFVCKLYTGEEENLFKKRMQAVFTNVHKFKPDASRDESKETYYIGLKKKRNVDKLDVFSNS
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for the catalytic activity and assembly of complex I (By similarity). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (By similarity). Plays an important role in carotid body sensing of hypoxia (By similarity). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
TYLQALPYFDRLLNIQPPPREKMFEFYERMHAAYIRPGGVHQDLPLGLMDDIYEFSKNFSLRIDEVEEMLTNNRKTQPYDVYDQVEFDVPIGSRLYTEGYQVPPGATYTAIEAPKGHMLADVVAIIGTQDIVFGEIDR
The following text describes a protein:
Function:
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MAAERGARRLLSTSSFWLYCLLLLGRRTPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLASDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIVSRTAKLTVAGLPRFTSQPEPSSVYAGNSAILNCEVNADLVPFVRWEQNRHPLLLDDRVIKLPSGMLVISNATEGDGGLYRCIVESGGPPKYSDEVELKVLPDTEVTSDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSRPGEMQVTIQNLMPATVYVFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNIRAYATSPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSFTINGLKKYTEYSFRVVAYNKHGPGVSTQDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDHPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAVPPPGPPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MASRILYILIVALSTFTTTEYDTSATHVLAPSTIAACSTPASQILLTLKRLVRWDAVYFLGIAEQGYTYEQQFAFFPGLPLLMQAAAHSLSSVFGSSVCNHVLLVISGILISNTCFVMATVALYKLSAHVLHDNHIAFVSAILFAFNPAGIFMSSIYTESPFALCAFMGMLNMVQDHTWAAALWWSGASSLRGNGILFAGFFIWDLLHPFAKHTIQTQTMYRIVRNTIALGVVVAPFILFQYYGWTLFCTENADTYRPWCNHKIPSIYSFVQAHYWNNGLFKYYTAQQIPNFFLAAPYLIVSCTGITQFALEHWTEFISVGFMTKKLKRPYSVLTLLPFVYLWMVMLGTCALFMHVQVILRFFTSSPVLFWVLAKWTVEWNGKSMFIRLLGFYYTTYPVIGAVLFANFLPPA
The following text describes a protein:
Function:
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Subcellular Localization:
Cytoplasm.
Sequence:
MTIERVGLVVHGGREGAAEAAREVREWCDENAVACTDIDVWSDTGRHSAREEVDAAGDPDLVVTLGGDGTFLRGARLAAENDALILGVDLGRVGFLTEVPAPAVRSALDAVRDGGLEPESRMLLTLRASRLLEIPAEMEALLRYGRGPLLPPPRVRTDCESGDEWGIALNVTALNDVVLEKLSRDRQISVGVYIAGRLLASYSADALLVATPTGSTAYSFAAGGPVVSPRAEALVFTAVAPHMTFDRSVVTAPDEPVGLRILERSGRAAVSIDGQLRGVLDPGDWLGVYAAPRRLRAVRLGPMDFYGRLRERMRLTDAPAAVADGTPAPLWPVSTPPPGDLAHLALPVPGAEGASGDLLREQS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEHMTMGAEGIKVEAADITLDQVTAAIQLQEQLKVEPHIDGAVLAGTMDCLVDYNLGTQLTVEQEIQIGDGPSPCLQYDMNCLTKKPPKPRQRKPSGEGPFSCGQCSKSFGRSMDLARHQKAHKGERSFLCNICGKNFRRHTSLLIHARIHTGERPYQCTVCGKSFVQRQHLTTHLRTHTGEKPFQCIECGKGFRWRSELLKHQKNHTDKASAAFDDLASSFSKEEWMELEEWQKELYRNVMKETSETLISLGEGLVEKAIVEPAASLAIDCTSNLPFCPGAVTCTGQLDGGIGQLNQPMGTAEGKDVAFTEGSDKIRIKFLDDVPKTDRVHACAECDKVFYNKRMLKTHLRAHLGDRSYICNVCGKCFRRHTSLLIHERIHTGERPYQCPQCGKSFVQRQHLNTHQKTHTGEKPFHCTECGKGFRWRSELAKHQKVHEEEVTDSSAKDDRGVSNIGEKDGGSISAGSAHSEPQAGDSQNKEGGSKKPAGAIAHPRNQKSDKAHACAECGKIFYNKRTLKSHLRSHLGERSYICNVCGKCFRRHTALLIHERIHTGERPYKCVQCGKSFVQQQHLTTHQRTHTGIKPFPCDVCGNSYRWRSELAKHQKIHEEEKSGNGSEDGQKETSVRKRCLRRVERGTLERGKALGKRARLLLRQRAQKAERTHSCPECGKNFINKRTLRTHQRVHTDERSYICNVCGKSFRRHTSLLIHERIHTGERPYQCAQCGKSFVQRQHLTTHLKTHTGEKPFHCAQCGKGFRWRSELAKHQKVHEDESLLIGVNSCKTKTSLENDWKSVNGTQAELEQSGDVGRAGKSQQPPQERPFQCSQCEKTYLRSSDLLKHQRSHLGPLGERPYVCNQCGKCFRRNTSLLIHERIHTGERPYQCAQCGKSFIQRQHLSTHLKTHTGEKPYPCNVCGKSYRWRSELVKHQRVHGTEATVTFDDMSVCFPEEWKDLEEWQKELYKNMMKENSDSLISLGEVWTNKNGKEMNPDRPTDMLESSDSKEHVSLGVEALNALDHMGAPQDVRVFSSTQLQGDEPQTSADALRGLHQSLGFLEQRRPPREKLFSCSECEKRFSRSSDLLKHQRSHQAGEKPNLCNECGKVFRRRTALFIHKRIHTGERPYKCKQCGKSFIQRQHLTTHVKTHTGERPYPCNLCSKSFRWRSELLKHQRVHPEIPPVQ
The following text describes a protein:
Function:
Probable methyltransferase required to silence rDNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDFWRTDDSSTWQEESWSQNLHESLFKSCESKKQTTKKSKKRDSEVPSIKEKRIQSAEGESICEEEAVPRKKKKKGNAKLQNGGSDDVQNPEMPARKEKFRPKIPAISSETALHDLNEPVTQNSDVSSTEINEVENAVVQSKDKTKKNRKRKPKNNKFKDKTTAGEGENGTDCGHDVQSQITDVKESSVESSEANLSGKERRKLRRKLAKQQLRTEKQEQAEIMDKKMSDESKIDLPSTDDSESKGTDEDDIPDTSNHGDTKSNLILANTRRKTQMKPDVSLKIQMESQLKSSQFRFLNEQLYKVTGDKAKDMFAADASAFLTYHEGFTQQVKQWPSNPVDIFIEVLKKRPASLVVGDFGCGDAKIARSVKQKVHSFDLYPMNKHVTVCDTKKVPLKDGVLDVAVFCLALMGTNWMDYVKEANRVLKTGGLLKVAEVASRFTSPASFLSVMKSLGFQLKTKDVSNKMFYLFDFKKKQVVTAVPAVKGPILKPCLYKKR
The following text describes a protein:
Function:
Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.
Sequence:
MVVSYIPRMRSASSINLSFNFQIRGFLMEDDELPSSLSAELAAIGGAVRFRQADDLEEEIREQFSHEFWKEEEASCSSQIRRDVNPISDLLRVDKSVKHGDLTPLELLQAQNQRTQNEVKQEDPDEEEVLQSQKSASLSDDEEIKEESLSDGELIDEMEDPGPSKSRQFPSANDSNESDEYLPSDGSLNEDSGDDYVEEKEEKGPKVKKQRRSNEETKKKQHYGDDGDDKTFESRIRRFLAQKELNRIEGDDEQGMKTIKNDLHINSNIWSNLYKYQKTGVRWMAELREQRVGGILADEMGLGKTVQTAVFLRAIAESKKEEQLTGYIGLGPCLLVCPATLLHQWVKEMHNWHPLCRVAILHSCGSHKGSNSTLINKMANGRSSGSMLITSYSTFYKERKALTQIGWHYVILDEGHKIRNPEALISMAIKEVRTPYRLLLSGSPLQNSLKELWSLIDFIFPARLGTLQTFMEKFSIPITMGGYANATQIQSETAYKCALVLRDAINPFILRRMKKDVKMAIELPNKSEQVLFCDLAPFQRSLYTEYLSSRECNLIRAGRLESFSGLMLLRKLCNHPDLVTGGPNKHLDQDVDSDPSLVFGWPERSGKLQVVRSLLQLWKKTKEGKTKNKILLFSQSRKMLTIMEQMLIVDGHGYLRMDGATPIGKRINIVNEFNETDSIFVFLLTTRVGGVGVNLCAANKVVIFDPDWNPSTDAQARERAWRIGQKREVTVYRLMTTGSIEEKMYHRQIFKQFLANRVLKDPKQRRFLKTNHLHDLFTLSDGDTTGSTDTGTIFAGETKELTKKNFFDAHEKEREKMRAERRKKKRKNGEEEEKKDEEEGSDDEKGDDSLSDQRREALKKFAAAVSRDLSMLIPVKKTKEESDKSNEKGEDLVLAELLSRNGVRSVVKHDEVIGEGKKRSDNRLEESQADSVAKQAAAAIRKRPRFNFLQQNGLIKGRTDNSPGSSSSTRFGDGKKTNGGDLMEAIRERKRRQGANGVPLSQSSKLTKLAEEVKDFLYSCPFSCARTDQIINRFKKNISAKDQLQFRSILKEISHFDSTSKEWQLKEEFR