lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.
Subcellular Localization:
Cell membrane. Synapse.
Sequence:
MREAADRRQQLEAEHEQALAFLNSRQQEINLLQKVQAEAEKEREEVVHLLESHMDKMQVKVHDLEQKCRAQSEQCNILSKELEKYHLGSDAEDTLNTDSQEKNLCNSYNSLQRQAEKSDERSDGSPLVSELPIVQQHKRDKPEQLTVKPTVQTRSRSSSPMQASLSEMDDEVRPPSRSKTRYTGQVRLCTARYSYNPYDGPNEHPEAELPLVAGKYLYVYGNMDDDGFYEGELLDGQRGLVPSNFVEFVQDKEKLSIEGVEEQGRLEQSCLSLTTIDGGGPLDSISSDVLDHCSNGTGALDGEELGEDIVPYPRKINLIKQLARSVIVAWEAPMVPLGWGNINGYNILVEGEVRSSVPFGGRTKLLLEKLDLAAFTYRVSVQSVTDRGLSDELRCTLLVGRNVVVAPTGLRMDDILRDSAELSWLPSNSNYAHVVYLDGVEHAVVKPCSYKLRFVNLKAATVYKVKVLAKPHQVPWHMPLEQREKREAGVEFCTQAAGPPLPPQEVQVQCGHAPGILQVRWKPPAMSPIGMSNGANIIGYAVCTKGQRIAEVLYPMADYVAVELNRLQCLEAREVIVRTLSAQGESQDSHVAVIPNHLLVPLSKTLPLPHRMQPPLPTQQSHTMPHHPQILPRHTGPQPPTHLQPLPICPNQPPAHLHPHRMPHPTQPSPPHLQPLLAHPIPQPQPSIPMPQPQSSMPMPQSQPPMPMPQPQQPMTMPQPQPPIPMLQPQPAIPMPQPHIPQLPLPQPQRPLSARELETKEPGPGMLHHGGGPPQPWEPGCSPSGIPTGMPHGHTLEAPACPNRRSPSPQRILPQPRGTLIPDTVAKAIAREAAQRVAAESGRMERRSQGFHSQNSDEEEDEESYQARRRGASVDDFLRGSELGRQPHYSHSEEYHTESSRGSDLSDIMEEDEEELYSEMQHEEGRRRNSHNALKTGGSTLSSGQLDRDSYRKAPHRGPQPQRRPLTVPSIEITTESNSEGNLSPVKEDVYYGSVARHRTWSSRRHGGRRPPYDGYRDRSRRSPPYYDESEQEDFRIFVALFDYDPLSMSPNPDAADEELPFKEGQIIKVYGDKDNDGFYRGEIRGRSGLIPCNMVSEIRAEDDETMEQLMKQGFLPLNTPVDRIEQNRRGRHPVATRRMVALYDYDPRESSPNVDVEAELTFCAGDIVAVFGDIDEDGFYYGELNGHRGLVPSNFLEEVPDDVEVYLTDTPSHHGQDESNPAPAARPEAKRVPVERTVPAPAPGRPASPTVRPLLPVGPVRPLSPARGPRDLASKKKKGLLSKGKKLLKKFSK
The following text describes a protein:
Function:
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Localizes at sites of polarized growth like the hyphal tip.
Sequence:
MYNPYQQQQQGMGYNPQQQTGYGYNNYQMPQQPQFNQQPMYPQATGFVPQQPNLYGSNFQTSGGSGMAPQQTGFSQQQTMQPQQTGYIQTQPTGFGGTAPIVTENSELKIPSIRLSFISAEDQKKFEHLFRTAVPKGEQSISGDSASGILLRSGLSAVTLAEIWNLSDIDKTGSLLFPEFALSLHLCSMAKRGEPLPGILPEKWLNEVRSFVDQINFTVPDDPSKILANTPFANFAPKKESDWLAPQSTGYLQNQSAPPMTSFQPQVTGFGGQGLVSQATGGVPMPSTTFGNAAGLTAQRTGGGTLIPLQPQQTAGLIPAQKTGPLNPQTTGFNQQSLQQQRTGGLPQQLTGYQGPPQGQGQQLQQQRTGGFPQVQSQPTGGFVPQTSFQQPQLVSQRTGPMQAQPTGSLQAQPTGRPGEWGFVSMPTGGIPGLNAMQQHFLPNNQLPTSNLHSAMDNKLKENVTWAITKQEKQIYDGLFQAWDNQKKGYVDSNVALNVFTKSGLSRSDLESIWTLVDTDDTGKLNKNQFAVAMHLIYRRLNGYDIPLRLPPELIPPADRTLKDTMDSLKNSLKGGVNNKPTKPPKPQSKPDGTRFKNDDNNFGYVSNVRHRRKSTSDESHKSSVKSSSDYDLSIEDMKKLIHEKRILLDALDTEDQANNYSRSSSSMHEKQIIENLKKEIMAVQTKLDERGNDGPSSDERNKLLATLDHLTRDVVPRLISDIHKVNQEISRKKAEVFKLELLKKNPSWNPEDDESQIQGTGPNGEVTDYDRIKYQSRQKLKQRMAALTGKSTGGNSDLDLELKQATEKAQDEASRQSEMIQDIAAGIKTMEDECAAKLSSSVTEDVGHEKWEQGKGISSEVAKFVKELEAFSKEQRRNIAKSQKQEQTREPLAKQQTNASLVSDSGAAKSAYATPEERAAYIKQQAEKRMNERLAKLGITRKSKSTEQKPPVESKSVSNHSPVPDSEVKSVTRNANEVEVQKPKPDSQPVSKNREPAEQPNSKADTNSVGSQNVVSNTNDDTSGDDDDEEYKAILKQKQEMEARERERKLRKQKAKEERLAKIKKEMEEMKKREMEESQDEEEEEAKQVTSVHVSRAQSSNANSNVIPQQETATENVNTVSQPTSTDTAKQSYHPHESNPFSKMNNNTSQNSTVTNTGTNPFFKSTSQETKIDPHKAEAQRASQRGVASSGGWSDSEEEESEEESPNRAGAAKLASLLFGGMPQPPTTSSSSLNNDAEKVSEQEHENAKQVASTPLSNDDNGKTDSGPSGFAGENESSFSQAPPIPVDAPPAPNSIPPPPPPPPQFSNEAPPVPDSIPPPPPPPSVPSTVPALPDSMPPPPPPPPPPAAPNNTSSSQQASGAPNIGALLGQITGGASLRKVETKVSSGATVGRVL
The following text describes a protein:
Function:
Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3'. Involved in regulating energy expenditure, body mass, voluntary physical activity, mating behavior and reproductive longevity, acting through the hypothalamic-pituitary-gonadal axis. Acts as a transcriptional activator of target genes, including Ndn, Pcsk1, Mc4r. Is also a transcriptional activator of KISS1 (By similarity). May act centrally to regulate function of both white and brown adipose tissue. Together with NHLH1, required to maintain migration and survival of cells in the anterior extramural migration stream (aes), which forms the precerebellar nuclei. Also, in concert with Nhlh1, may determine fate of gonadotropin releasing hormone-1 (GnRH-1) neurons.
Subcellular Localization:
Nucleus.
Sequence:
MMLSPDQAADSDHPSSTHSDPESLGGADTKVLGSVSDLEPVEEADGDGKGGSRAALYPHPQQLSREEKRRRRRATAKYRSAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLDV
The following text describes a protein:
Function:
Involved in DNA damage response (DDR) mediated through its interaction with phosphorylated H2A proteins hta1 and hta2 which mark the discrete foci of DNA damage.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with chromatin. Relocalizes to discrete nuclear foci at DNA double strand breaks (DSBs) following DNA damage by the HO endonuclease and ionizing radiation (IR). Focus formation requires interaction with phosphorylated hta1 and hta2. During mitosis, localizes to spindles and concentrates at spindle midzones at late mitosis. Localization to spindle midzones requires ase1, but does not require phosphorylated hta1 nor hta2. Localizes to spindle midzones in anaphase.
Domain:
The N-terminus adopts a forkhead-associated (FHA) like fold; BRCT domain is characteristic of proteins involved in DNA damage signaling (By similarity). It is required for localization to chromatin which flanks sites of DNA damage marked by phosphorylation of hta1 and hta2.
Sequence:
MEIQFGNQRCRMVNSGGFLATDGSHLKEMETDDVLVEFLNIEHQLFIRNIRAIVKIADTTVLPSASDKKLLYYVFDETRVRINDTPVIFSKLEEDNANVNEGSKMGVMTVPNTPQKPNLQQQKFEAINANEDQIDYSSNLEQNYNSLIRQGSDQVIPLSRFASEKSALELEKELFSERIPESQSAAEPVLKVENSENDLDEKLVLDGQHVEGDHSSDTEEEVVSEDQKQLNKTDDESTFIESHQIYIQGETKSPSSVSQSLSGDPSLKPAEVFDRKQSAEINSPIEKDVNPQQNISDSSIKNNSIHSDEVNPEVRPDLTPSNENEESKRSAPEIALKEKESTSQDESNREAEEAPISTNYSFPSSSLEDQPDKNVQSSAVENKNKHTNLVTSSFNLTKPMKSFIRRNGLRVQESVTDETDFVILGSPPLRRTHKFLLATSLGIPLVSSQYLTDCIKSGKVLDFRSYKYKDEEAEAKWGFRLDDIHRRTCFNGKRLYITKAIRDSMVGDSIHGLYSILETSGAEIVGDIKRAQEKDTIILAQPDNDQEGRNMSATGLNVYKIELVALSILRDRIDFDEFLIDYDADSPTKVIGKRNVSKASRTGQGRKRSSRSSWNKPSAKEQRT
The following text describes a protein:
Function:
E3 ligase that regulates nuclear lamina integrity and the association of viral chromatin with transcriptionally-active host chromatin. Acts thereby as a herpesvirus-specific antiviral factor and mediates the ubiquitination-dependent proteasomal degradation of PCNT.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MDSDFSHAFQKELTCVICLNYLVDPVTICCGHSFCRPCLCLSWEEAQSPANCPACREPSPKMDFKTNILLKNLVTIARKASLWQFLSSEKQICGTHRQTKKMFCDMDKSLLCLLCSNSQEHGAHKHHPIEEAAEEHREKLLKQMRILWKKIQENQRNLYEEGRTAFLWRGNVVLRAQMIRNEYRKLHPVLHKEEKQHLERLNKEYQEIFQQLQRSWVKMDQKSKHLKEMYQELMEMCHKPDVELLQDLGDIVARSESVLLHMPQPVNPELTAGPITGLVYRLNRFRVEISFHFEVTNHNIRLFEDVRSWMFRRGPLNSDRSDYFAAWGARVFSFGKHYWELDVDNSCDWALGVCNNSWIRKNSTMVNSEDIFLLLCLKVDNHFNLLTTSPVFPHYIEKPLGRVGVFLDFESGSVSFLNVTKSSLIWSYPAGSLTFPVRPFFYTGHR
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MNSDSLTLNLLFLSLNHHPQRAPPPKKKKEKKTRLLMALPMQRSLLRSFVQSMHEEGIVNDDFYQLLAMKETVRPDYVVRAVTSYCLSAQNLFSHLTYHICQPEVDYHQVNTAACEFYARTSSCSRALYWTKNEYSKLRRKFETLVQMERKIIDLENGH
The following text describes a protein:
Function:
Receptor for egr. Involved in induction of apoptosis by triggering JNK signaling. Mediates the tumor suppressor activity of egr which eliminates oncogenic cells from epithelia, thereby maintaining epithelial integrity. Following UV-induced epidermal damage, binds to egr released from apoptotic epidermal cells and plays a role in development of thermal allodynia, a responsiveness to subthreshold thermal stimuli which are not normally perceived as noxious. Together with Moe, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr.
Miscellaneous:
MISCELLANEOUS: 'wengen' is named after a village at the foot of the Eiger mountain after which the TNF gene egr is named.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein.
Sequence:
MMPPRLPGGHGGAMRSRSSSSGHHLNTTFHKRRRRRQQHHIGGSHISISHGSYLALLLLSTTCSLVATSASSSSSAANTDIAPPDPPPVSQVSIASSSPCAPQHWWDSQRDRCTPCTRCQGEMIPLRPCQLHTDTICGSIYDLKIDWVVLAKTEPNWKERRKSSEYEHFEHNAPLQHLTHEQLQQLHEEAAAAWVLDWQTGVLYVAVLTCLVFFSVAACILIHHMRQWRRMERRLDQDVEELSTKLMAKLAEVQSLDGGTFFIGNADALRGLPASAATTHPATTQSGIFQPQHVLLPEKRGKHQERRILKTLQPGNVYIEESNAGLGGMGVGLGVRGCSGLKG
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MACTKPTLVLDIDNTLVYGRATKRPGLDEFLARVSKLYEIVIFTSSNQERADRIIDHILKVSIARRFYCNSCVRGTKPLVILGQDLTRVVAIDDNPLTFASNEENGLAIVPFSEWSMEEEERERHLIKLLPLLEGIAGLEDLRPSLKQWKEGKFQGDIIPLLDGNNHDVNKDYINRSLQIGHDVLSVMYFFHPERKNKQGLCEWNLPSSFKVSDYNLKEHRLSFEASAIAQTQTV
The following text describes a protein:
Function:
FixI is a pump of a specific cation involved in symbiotic nitrogen fixation. The four proteins FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHVTRDFSHYVRTAGEGIKHIDLAVEGVHCAGCMAKIERGLSAIPDVTLARVNLTDRRVALEWKAGTLDPGRFIDRLEELGYKAYPFETESAEVAEVAESRFLLRCLGVAAFATMNVMMLSIPVWSGNVSDMLPEQRDFFHWLSALIALPAAAYAGQPFFRSAWRALSAKTTNMDVPISIGVILALGMSVVETIHHAEHAYFDAAIMLLTFLLVGRFLDQNMRRRTRAVAGNLAALKAETAAKFVGPDEISQVPVAAISPGDIVLLRPGERCAVDGTVIEGRSEIDQSLITGETLYVTAEQGTPVYAGSMNISGTLRVRVSAASEATLLAEIARLLDNALQARSRYMRLADRASRLYAPVVHATALITILGWVIAGASWHDAIVTGVAVLIITCPCALGLAIPTVQTVASGAMFKSGVLLNSGDAIERLAEADHVIFDKTGTLTLPDLEVMNAADIPADIFELAGRLALSSHHPVAAAVAQAAGARSPIVGAVEEAGQGVRADVDGAEIRLGRPSFCGAEALVGDGTRLDPEASIVAFSKGAEKFILWVRQGLRPDAQAVIAALKARNIGIEILSGDREPAVKAAAHALAIPEWRAGVTPADKIARIEELKRRGARVLMVGDGMNDAPSLAAAHVSMSPISAAHLSQATADLVFLGRPLAPVAAAIDSARKALHLMRQNLWLAIGYNVLAVPVAISGVVTPLIAAAAMSGSSILVMLNSLRARSDSREIV
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQPIKSFYLFSKLFGLCPYPLDPTVPVNTRASYVKQLLPTYTVLLLYSSCLVSIFWQSGNTSDISNAANWIQFIPNSFAYVFSLVFAIRHRTMANEILTTFAIADDKLRTQFGISFTMPNVKMRRVSILACIVTMTCGSTIGALTYLIGVNWNRIWTLLYWIAFCMPKFAGCILYLSDRAMLLLRGMNNFPVGVENLALQPQTHGHGPQYKTLNMAMGGNHLPSMHEGKLNRLTTLATIKIRAISPLDSIQHIREVVELLQDLSVKINHCFGKQAIFSLLSAFTCVTVQLYYMLNHIKSGFTASRSEIYALASCSLLFLHGIEFWSLFTSGENVRLKWKKVINFLFFMKSKSADDDFRTKVDDLISFMVTNPLEFNAYGLFPIDLSVLTGIASSITTYLIVLIQFKISEEQSSGYDDDSDEKSQIQYSAH
The following text describes a protein:
Function:
Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non-dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Sequence:
MTMDALLARLKLLNPDDLREEIVKAGLKCGPITSTTRFIFEKKLAQALLEQGGSLSSFYHHEAGVTTLSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPPSATDTYRAGATASKEPPLYYGVCQVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPVKTAPPFSNDGLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQVGFGSSLGQVRGPGRSIAALAQGVSTRQIGSPEHVVLFQEGCRYNVMHVAAKENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRVRYVVDLYLNTPDKMGYDTPLHFACKFGNADVVNVLSSHHLIVKNSRNKYDKTPEDVICERSKNKSVELKERIREYLKGHYYVPLLRAEDTSSPVIGELWSPDQTAEASHISRYGGSPRDPVLTLRAFAGPLSPAKAEDFRKLWKTPPREKAGFLHHVKKSDPERGFERVGRELAHELGYPWVEYWEFLGCFVDLSSQEGLQRLEEYLTQQEIGKKAQQETGEREASCRDKATTSGSNSISVRAFLDEDDMSLEEIKNRQNASRNNSPPTVGAFGHTRCSAFPLEQEADLIEAAEPGGPHSSRNGLCHPQSHSRTLAGKRPKAPRGEEVHLPPVSDLTVEFDKLNLQNVGSSVSKTPDENTKTKDKILTSRINAVERDLLEPSPADQLGNGHRRTESEMSARIAKMSLSPSSPRHEDQLEVTREPARRLFLFGEEPSKLDQDVLAALECADVDPHQFPAVHRWKSAVLCYSPSDRQSWPSPAVKGRFKSQLPDLSGPHSYSPGRNSVAGSNPAKPGLGSPGRYSPVHGGQFRRMARLAELAAL
The following text describes a protein:
Function:
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation.
Subcellular Localization:
Cell projection, podosome. Cytoplasm. Nucleus, nucleoplasm.
Sequence:
METEQPEETFPNTETSGEFGKRPAEDMEEEQAFKRSRNTDEMVELPILLQSKNAGAVTGKGGKNIKALHTDYNASISVLDSSGPQRILHISADIETIGEILKKIITTLEEGPQLPSPTATSQLPLESDAVEYLNYQHYKGRDFDCELRLLIHQSLAGGIIGVKENTQTTITLFQECCPHFTDRVVLIGGKPNRVVECIKIILDLISESPIKGHAQPYDPNFYDETYDYGGFTMVFADHRGRPVRFLMRGRGGFDKMSPGRGGRPMPPSRRDYVYMSPHLMTYNRKGRPGNRYDGVVDFSADETWGSAIDTWNASEWQMAYEPQGGSRYDYSYAGCHGSYGDLGGPIITTQVTIPKDLAGSIIGKGGQWIKQISSIKIDEPLEGSEDRIITITGTQDQIQNAQYLPQNSVKQYSGKFF
The following text describes a protein:
Function:
Required for resistance to DNA-damaging agents.
Subcellular Localization:
Cytoplasm.
Sequence:
MAMYQNMLVVIDPNQDDQPALRRAVYLHQRIGGKIKAFLPIYDFSYEMTTLLSPDERTAMRQGVISQRTAWIHEQAKYYLNAGVPIEIKVVWHNRPFEAIIQEVISGGHDLVLKMAHQHDRLEAVIFTPTDWHLLRKCPSPVWMVKDQPWPEGGKALVAVNLASEEPYHNALNEKLVKETIELAEQVNHTEVHLVGAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGINENMTHVEKGLPEEVIPDLAEHLQAGIVVLGTVGRTGISAAFLGNTAEQVIDHLRCDLLVIKPDQYQTPVELDDEEDD
The following text describes a protein:
Function:
Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
Sequence:
MKLIFGANGKLGTDFKELFDSIGEKYIATDKDEVDITNGDFLRAYIKTMHQNYKIDTIINCAAYNDVDKAETEKELCYKANAEAPANLAMIASEIGATYITYSTDFVFNGMTTNYLYNESTGYTEEDEAHPLSAYAKAKYEGELLVSQIIENPENTSRIYIVRTSWVFGKGGMNFVEKIIELSKEKDELKVVDDQVSSPTYSKDLAYFSWELIKKGCESGVYHLTNDSIVSKYEEAQYILEKISWKGNLIRAKSEDFNLLAERPKFSKLSCKKIKEKLGVSIPNWKDAIDRYFKENNK
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MFKHILIVLSHLALLGYSADWCYEHEECAPPHWYLHYPSCGLSSQSPINIITYNSVADSSLGPIIVEGSDATSEGELGNNGHSVEVTLKARYTLSGAGLTDAYTLAGFHAHFGNSDPALGGSEHQINGKAFPLEIHFVFYNSKYIDLTEAKKQSDGLAVIGVLFQIGSFNYALDHLLGQLSQVAYPGQKTSVRADLRKFLPARIGYYFKYNGSLTTPTCSENVTWLVAGNVQTISLSQYTQIVSSLYFSQPGAAEPLPMLDNFRPTQPLNGRTVSVYRK
The following text describes a protein:
Function:
Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level. Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression; RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MGKTVGSLGQGTRPDPVRSFNRWKKKHSHRQHQKKERRKQLKKPEWQVEREGISRLMQNYEKINVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETICFHATNLQMLVLDEADRILDMGFADTMNAIIENLPKKRQTLLFSATQTKSVKDLARLSLKDPEYVWVHEKAKYSTPATLEQNYIICELHQKISVLFSFLRSHLTKKSIVFFSSCKEVQYLYRVFCRLRPGISILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEEQGMVQQLLQKKVPVKEINLTIIFFLLKRINPEKLIDVQKRLESFLAQDQDLKERAQRCFVSYIRSVYLMKDKEVFDVNKLPITEYALSLGLAVAPRIRFLQKMEKQPNKELGKNQVTEAIQPRAPSLTSDEVEEFRAYFSEKMSILHKSGKRLEETEHSLASGESEEQDEETEDEEMEDHVGQTREPPTDSVPRSEEAQKVKEVPVQFLDRDDDEEDGPDADFLTVKRRDVFGLDLKENEALSKKEPSKSSVKKKLTKVAEAKKVMKRNFKVNKKITFTDEGELVQQWPQIQKCATNDVEEEDDTGGINLDKAKERLQEEDKFDKEEYRKKIKAKHRERRLKEREARREANKRQAKARDEEEAFLDWSDEDDGGFDPSTLPDPDKHRSSEESESEDTKHKMSDTKKKQEMRKRNNTEVDDVRPRSRHGKKAKWETLEPLDTGLSLAEDEELVLHLLKSQN
The following text describes a protein:
Function:
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Miscellaneous:
MISCELLANEOUS: The porphobilinogen subunits are added to the dipyrromethane group.
Sequence:
MTEKALRLGTRRSKLAMAQSGQVADAVSQVTGRPVELVEITTYGDTSREHLAQIGGTGVFVAALRDALLRGEVDFAVHSLKDLPTAQHEGLVVAAIPEREDPRDVVVARDARKLTDLPRGARVGTGAPRRMAQLNAYARTHGMEIETVPIRGNVDTRIGYVRSGELDAVVLAAAGLNRVGRIDEVTDFLSVDTVLPAPGQGALAVECAADNASLIAALAELDDPFTRAAVTAERSLLAALEAGCSAPVGALADLLADGQTVKEMRLRGVVGTTDGSTLVQLSTTGPVPETHEAALALGGELAAEMLAQGAAGLMGERAQ
The following text describes a protein:
Function:
Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
Miscellaneous:
MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B).
Subcellular Localization:
Cytoplasm.
Sequence:
MSQGHRSEEVVRVNLLFFAKSRELVGTSSLDNFPLATSGGHLSGSAVLGTICERFPELVAIRDSVIIAHNEQYCEDLTEPISLADGDEIAVIPPIAGG
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
Miscellaneous:
MISCELLANEOUS: Present with 1617 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSVQDTKAVEFSMGHIRSSSVSLVAEATSNTNSEDKLSKVQLYEDLCRYEDTLSKLVESVDRFKPNLDIAKDLIRTDEALFENVKLLAEYDNIYRNLQKIDKDSEELDSKTRKILEILNECHDELKALPMLEQVEFEKNTILQQRSKINSTELLDYATKLSKFTKIPPTFDKGAVGPNNFIWPAEDALRRGMLAMASLHSKELTRIPGEEVEETEVPTVPPSQSEEQKGQMAKKEGTPKTDSFIFDGTAKEVGDEADNTKDKEKEENNDDALDLDLDLFDPDDF
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Sequence:
RLANIRPGVYGPLECSTLHCTVLLNDQHALLTCSLVTKLLSYSEPVQLAHPTRLLLEYTGAKYEEKTYVCGEAPNYDKSGWFSVKFKLGLDFPNLPYLVDGDKKIVQSNAIQRYLARKNKLCGETEEEKIRLDILENVVMDFRMSFIRMCYTDYENLKPEYLKTLPDVLKQFSDFLGNRKWFAGDRLTFGDFIMYDVLDQQRIFLPTCLDAFKNLKDFLDRFESLERISAFMKSGRYIRTPIHNRMAKWGNKKM
The following text describes a protein:
Function:
May function in hyaluronic acid binding.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MLAELSMILLVASVCRGLPFYNGFYYEHILNNKTNNGNGEVIHFNGVRLVVNTPDDSLFGYRGGNVTLPCTFHYEPKLNSTRRFRVKWSKLHNDNTKERDVLVAIGLRHRSFGEYKGRVHLIQNQPNEVSMVITDLRLEDYGKYKCEVIDGLEDESGIVELELRGVVYPYQPPHGRYQLNFHDAKKACEDQDAMMASFEQLFKAWEEGLDWCNAGWLMDGTVQYPVTLPREPCGGKDTAPGVRSYGERHKHLHRFDAFCFSSALKGKVYYLEYPERMTFAEAKAACQDDGAQIAKVGQLFAAWKFIDLDRCDAGWLDDGSVRYPIASPRPNCGPPEPGVRSFGFPARYMKFGVYCYKMS
The following text describes a protein:
Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage; MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage and alternative splicing; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing; MISCELLANEOUS: [Isoform 5]: Produced by alternative splicing; MISCELLANEOUS: [Isoform 6]: Produced by alternative splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSKGILQVHPPICDCPGCRISSPVNRGRLADKRTVALPAARNLKKERTPSFSASDGDSDGSGPTCGRRPGLKQEDGPHIRIMKRRVHTHWDVNISFREASCSQDGNLPTLISSVHRSRHLVMPEHQSRCEFQRGSLEIGLRPAGDLLGKRLGRSPRISSDCFSEKRARSESPQEALLLPRELGPSMAPEDHYRRLVSALSEASTFEDPQRLYHLGLPSHGEDPPWHDPPHHLPSHDLLRVRQEVAAAALRGPSGLEAHLPSSTAGQRRKQGLAQHREGAAPAAAPSFSERELPQPPPLLSPQNAPHVALGPHLRPPFLGVPSALCQTPGYGFLPPAQAEMFAWQQELLRKQNLARLELPADLLRQKELESARPQLLAPETALRPNDGAEELQRRGALLVLNHGAAPLLALPPQGPPGSGPPTPSRDSARRAPRKGGPGPASARPSESKEMTGARLWAQDGSEDEPPKDSDGEDPETAAVGCRGPTPGQAPAGGAGAEGKGLFPGSTLPLGFPYAVSPYFHTGAVGGLSMDGEEAPAPEDVTKWTVDDVCSFVGGLSGCGEYTRVFREQGIDGETLPLLTEEHLLTNMGLKLGPALKIRAQVARRLGRVFYVASFPVALPLQPPTLRAPERELGTGEQPLSPTTATSPYGGGHALAGQTSPKQENGTLALLPGAPDPSQPLC
The following text describes a protein:
Function:
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix (By similarity). Fibrin has a major function in hemostasis as one of the primary components of blood clots (By similarity). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (By similarity). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (By similarity). Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy (By similarity). Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (By similarity). May also facilitate the immune response via both innate and T-cell mediated pathways (By similarity).
Subcellular Localization:
Secreted.
Domain:
A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
Sequence:
MSWSLQPPSFLLCCLLLLFSPTGLAYVATRDNCCILDERFGSFCPTTCGIADFLSSYQTDVDNDLRTLEDILFRAENRTTEAKELIKAIQVYYNPDQPPKPGMIDSATQKSKKMVEEIVKYEALLLTHETSIRYLQEIYNSNNQKITNLKQKVAQLEAQCQEPCKDSVQIHDTTGKDCQEIANKGAKESGLYFIRPLKAKQQFLVYCEIDGSGNGWTVLQKRIDGSLDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISMQSTIPYALRIQLKDWNGRTSTADYAMFRVGPESDKYRLTYAYFIGGDAGDAFDGYDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYHQGGTYSKSSTTNGFDDGIIWATWKSRWYSMKETTMKIIPFNRLSIGEGQQHHMGGSKQAGDV
The following text describes a protein:
Function:
Positively regulates a late step in synaptic vesicle exocytosis.
Sequence:
MAAFVAKQMLGSKMNAVKGLGGNDSEDGDTKDKDDEAERERLEAIKEAEDRRKEKHRKMEVERENMRQDIRDKYNIKKKEEAPEAETLKEPDNPLMRKKKTPEELAKEAEEADQDELTKLKNTLETQVNEWKSQIESKCVIQ