lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level.
Sequence:
MAHKTQTLNTTDLSRLSEDDRIAVMQMVKENELSVEEAIAKVKGQTGTDRTMTLSKIVGGKFDRRKRMAFRKDRGRLYLELQAVKASAFYVLACTVKQGRDLLAMNKNNTATPFVKAYITPELKDKSSKRKTQPRKNTVNPMYNEQFSWEIRANTDLDAMKLHIEVYEHAVLRRSQFMGSMAFPLAEIFEGGSLQGWFRLLDQTKGDFQFIPFKPKVKNEAAMSTRPKSKDVVKSQPANAEPDKPLARHAPAASKPVPPSPAAPASPAPPVDTLAGKQKVLSNVSAGSFKFLKVLGQGSFGKVLLAEEKATKEVFAVKILKKTVVVEDDDVECTMIERRVLELAGGSPFLTNLVATFQTPEHLYFVMEMVTGGDLMFHIQKKRRFPTELTRFYTGEICLGLWFLHKSGVLYRDLKLDNVMLAGDGHIKIADFGMCKENMWGAATTTTFCGTPGYLAPEIIKELPYGASVDWWSLGVLIFEMLLGDSPFEGEDEDELFNEILTKKLSYPPRLAPEAKALLDGFLQRDPSKRLGCGRDGKKDIMEHPFFSSIDWAKLERREIKPPYVPETRDPREAANFDPEFTEADTSLTPSDPYDIANIDQGVFSKFSYVNEGFFTGQKPSTQPQRPALFDYAWYRPDLPRDEAARQLKGQEVGTFFVRESSTQPGCYAIAMVSENNKIWNGLVTPSVTGDGRVLYKLFVKQKFESLPELVTYYTQHPVTTGPSGNRLCLRA
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MEYQEGFASREYDNGLVYQLPNAQQVPRQQPGGPQLQQQHHSPGDTPPQMVTKYHTQIDVAAAAAAAAASEPDPEPETEQPFYVNAKQYHRILKRRVARAKLEESLKVARGRKPYLHESRHKHAMRRPRGQGGRFLTAAEIAEKERQEAEEAQAQGENK
The following text describes a protein:
Function:
Protease able to degrade keratin into peptides. Is responsible for keratinolysis by F.pennivorans, which allows this bacterium to grow on native feathers.
Subcellular Localization:
Cell surface. Note=Is cell-bound, probably associated with the outer cell envelope.
Domain:
Is composed of four domains: a catalytic domain, two beta-sandwich domains that may mediate interactions with substrate, and the propeptide domain.
Sequence:
MRKVLLIASIVALILALFSCANPSFEPRSKAKDLASLPEIKSQGYHILFGELRDGEYTEGKILVGYNDRSEVDKIVKAVNGKVVLELPQIKVVSIKLNGMTVKQAYDKIKALALKGIRYVEPSYKRELIKPTVVKPNPDMYKIRKPGLNSTARDYGEELSNELWGLEAIGVTQQLWEEASGTNIIVAVVDTGVDGTHPDLEGQVIAGYRPAFDEELPAGTDSSYGGSHGTHVAGTIAAKKDGKGIVGVAPGAKIMPIVIFDDPALVGGNGYVGDDYVAAGIIWATDHGAKVMNHSWGGWGYSYTMKEAFDYAMEHGVVMVVSAGNNTSDSHHQYPAGYPGVIQVAALDYYGGTFRVAGFSSRSDGVSVGAPGVTILSTVPGEDSIGYEGHNENVPATNGGTYDYYQGTSMAAPHVTGVVAVLLQKFPNAKPWQIRKLLENTAFDFNGNGWDHDTGYGLVKLDAALQGPLPTQGGVEEFQVVVTDAKGNFGVPTVFVSMMRDNGSCYYAKTGPDGIARFPHIDSGTYDIFVGGPDHWDRALAPYDGESIPGGYAIALRMAEERQASFVGFGVSPDATQLNVNFNSTLQVKFSTNLSTLKDPQFVVVDPLLRGVYGRVAYARNQTYDLSLLSGQISFGIQTLLPAATDITIQGTVTLNGEDIPVYGVLKAGTTWTIIDDFGGLNLGTDSQPIYVWWTIFGQ
The following text describes a protein:
Function:
Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Displays neither proline racemase activity nor 4-hydroxyproline 2-epimerase activity.
Sequence:
MRSTKVIHIVGCHAEGEVGDVIVGGVAPPPGETVWEQSRFIANDETLRNFVLNEPRGGVFRHVNLLVPPKDPRAQMGFIIMEPADTPPMSGSNSICVSTVLLDSGIIAMQEPVTHMVLEAPGGIIEVEAECRNGKAERISVRNVPSFADRLDAPLDVTGLGTIMVDTAYGGDSFVIVDAAQIGMKIEPGQARELAEIGVKITKAANEQLGFRHPERDWRHISFCQITEPVTREGDVLTGVNTVAIRPAKLDRSPTGTGCSARMAVLHAKGQMKAGERFIGKSVLGTEFHCRLDKVLELGGKPAISPIISGRAWVTGTSQLMLDPSDPFPHGYRLSDTWPRDE
The following text describes a protein:
Function:
Geranyl diphosphate synthase involved in pheromone biosynthesis.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MFKLAQRLPKSVSSLGSQLSKNAPNQLAAATTSQLINTPGIRHKSRSSAVPSSLSKSMYDHNEEMKAAMKYMDEIYPEVMGQIEKVPQYEEIKPILVRLREAIDYTVPYGKRFKGVHIVSHFKLLADPKFITPENVKLSGVLGWCAEIIQAYFCMLDDIMDDSDTRRGKPTWYKLPGIGLNAVTDVCLMEMFTFELLKRYFPKHPSYADIHEILRNLLFLTHMGQGYDFTFIDPVTRKINFNDFTEENYTKLCRYKIIFSTFHNTLELTSAMANVYDPKKIKQLDPVLMRIGMMHQSQNDFKDLYRDQGEVLKQAEKSVLGTDIKTGQLTWFAQKALSICNDRQRKIIMDNYGKEDNKNSEAVREVYEELDLKGKFMEFEEESFEWLKKEIPKINNGIPHKVFQDYTYGVFKRRPE
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of the peroxisomal translocation complex. The two types of peroxisomal matrix targeting signals, PTS1 and PTS2, are first recognized in the cytosol by their receptors PEX5 and PEX7, respectively, which then carry the cargo to the peroxisomal membrane. The peroxisomal targeting signal (PTS) receptor-cargo complexes interact with peroxisomal membrane protein (PMP) components of the docking complex. They have then additional downstream interactions with the translocation complex, leading to the transport of fully folded and oligomerized cargo into the peroxisome matrix. The peroxisomal translocation complex forms the retrotranslocation channel with each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 and PEX20 through the peroxisomal membrane (By similarity). Specifically catalyzes monoubiquitination of PEX5 and/or PEX20 at 'Cys-6' and 'Cys-8', respectively, a modification that acts as a signal for PEX5 or PEX20 export from peroxisomes to the cytosol, thereby promoting PEX5 and PEX20 recycling.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Domain:
The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5 or PEX20 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex.
Sequence:
MPPSEEIKLRAVSPRPDFKANYLEFANAPAIVRANQKDSYFETVLRDKLQNVIQIFKGQRFTHTHPEEIGVAAKALYLSLTTLLGTKTLGEEYVDLIYVSRDGKRIPRYLARAGFIFAYAILPYFLTRLFRRLKSSSTPKDEVTEEKINKELPISLRIEKYLSNMSYSKVLDTIMNLHIAVFYFSGQFYNISKRFFSMRYAFGHKINKERTPNGNYELLGGLIVLQLVMKSLGGFKGLIGSFTGNDEHDESNLRANNKDIMYGIPSEEEQEEAKQQLGIIDLSDPGQLPYIPESSRQCMLCLSYMTNPTAANCGHCFCWSCIIDWCKERQTVLCVGKKCWNSNCYHCIRLFYIPTLNKICFFFLLSFLSVRAASKEFKSTKEEFAELFNEELADIAGEDPHCPGPFPTGRTLGYFLVVF
The following text describes a protein:
Function:
Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Sequence:
MRTHTRGAPSVFFICLFCFVSACVTDENPEVMIPFTNANYDSHPMLYFSRAEVAELQLRAASSHEHIAARLTEAVNTMLSSPLEYLPPWDPKEYSARWNEIYGNNLGALAMFCVLYPENMEARDMAKDYMERMAAQPSWLVKDAPWDEVPLAHSLVGFATAYDFLYNYLSKTQQEKFLEVIANASGYMYETSYRRGWGFQYLHNHQPTNCMALLTGSLVLMNQGYLQEAYLWTKQVLTIMEKSLVLLREVTDGSLYEGVAYGSYTTRSLFQYMFLVQRHFDINHFGHPWLKQHFAFMYRTILPGFQRTVAIADSNYNWFYGPESQLVFLDKFVMRNGSGNWLADQIRRNRVVEGPGTPSKGQRWCTLHTEFLWYDASLKSVPPPDFGTPTLHYFEDWGVVTYGSALPAEINRSFLSFKSGKLGGRAIYDIVHRNKYKDWIKGWRNFNAGHEHPDQNSFTFAPNGVPFITEALYGPKYTFFNNVLMFSPAASKSCFSPWEGQVTEDCSSKWSKYKHDPAASCQGRVVAAVEKNGVVFIRGEGVGAYNPQLHLRNVQRNLILLHPQLLLLVDQIHLGEDSPLERAASFFHNVDFPFEETVVDGVHGALIRQRDGLYKMYWMDDTGYSEKGTFASVTYPRGYPYNGTNYVNVTTHLRSPVTRAAYLFIGPSIDVQSFSIHGDAQQLDVFVATSEHAYATYLWTGETAGQSAFAQVIADRQKILFDRSSAIRSSVVPEVKDYAALVEQNLQHFKPVFQLLEKQILSRVRNTASFRKTAERLLRFSDKRQTEEAIDRIFAISQQQQQQQSKSKKNRRGGKRYKFVDAVPDIFAQIEVNERKVRQKAQILAQKELPVDEDEEMKDLLDFADITYEKHKNGDVMNGRFGQARMVTTHSRAPALSASYTRLFLILNIAIFFVMLAMQLTYFQRAQSLHGQRCLYAVLLIDSCILLWLYSSCSQSQC
The following text describes a protein:
Function:
VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles. Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
Subcellular Localization:
Secreted.
Sequence:
MEHRGSFQLLMTLTLLGVLYSQTLALPLLGTYSTMRLGHTLPFDGANEPDQTQDSLKSDTDILQSSLPENDKSYIDASRTMDRNTRHADGLFTSGFSRLLGQLSAKKYLESLIGKRVSNNLPEEHGQAKRHSDAVFTDNYTRFRKQMAVKKYLNSVLAGKRSEEDSANLPEESEMNEPNLSETDEDALIAELLHHFLVSS
The following text describes a protein:
Function:
Pectinolytic enzyme involved in the degradation of xylogalacturonan (xga), a galacturonan backbone heavily substituted with xylose, and which is one important component of the hairy regions of pectin. Activity requires a galacturonic acid backbone substituted with xylose.
Sequence:
MNYPKAILLSLALLAMHSLNAEVVTYPAGVGVKTLNDFSVEVRQGSGPWLPVDVYPVKVDRVDEKGHNVEVASIAYFDFDGMVDVRVISNKERVNSVRVRPLSYKITPDCVGDTVTFSLSRPRNLSVEVNGDIFHNLHLFANPIDKFRPSDKEIQRALKKKKGSNLIYFGPGVHNLPNDTLFVPSGTTVYIDGGARVYGNIFTEGAHDVNIFGRGEVHPDGRGAGVWVRRSKNVRIDGIVVSQLPIGQCDSVELTNVKSISYYGWGDGMDVFSSSNVILDGVFCRNSDDCAAVYASTQGFKGGSNNVLVKNATLWADVAHPINIGGHGDPNGMDTVQNVTFRNIDILDQAEKQIDYQGCLAINPGDNTLVRNITFENIRIEDFRNGQLVNFRISFNPKYCVSTGRGIQNVLVKDVTYNGSGENLSIIAGYDENHKISGIRFVNLVVNGRKITDDMPGKPKWYKTGDMAGIFVGEHVENLSFE
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MDNKKGGLFKIAKKLRNGTKVWARAGYFKCKLLKITTTGAPCLFAGRLKRRYDATFQSMVEIFRQEIANDVTCGRVETALLYFVNKFFRSVGCFGKGKEREVKTDRQRDTGSGEQRIRLERDTETLYQSQLRINQVNGWMSGWMQISLILQ
The following text describes a protein:
Function:
Involved in C-to-U editing of mitochondrial RNA. Required specifically for editing the mitochondrial NAD4, MT-CYB/COB and RPL16 transcripts.
Subcellular Localization:
Mitochondrion.
Sequence:
MLIPHYLHQLQLCARNRTLTTAKALHAHIVKLGIVQCCPLANTLVNVYGKCGAASHALQVFDEMPHRDHIAWASVLTALNQANLSGKTLSVFSSVGSSSGLRPDDFVFSALVKACANLGSIDHGRQVHCHFIVSEYANDEVVKSSLVDMYAKCGLLNSAKAVFDSIRVKNTISWTAMVSGYAKSGRKEEALELFRILPVKNLYSWTALISGFVQSGKGLEAFSVFTEMRRERVDILDPLVLSSIVGACANLAASIAGRQVHGLVIALGFDSCVFISNALIDMYAKCSDVIAAKDIFSRMRHRDVVSWTSLIVGMAQHGQAEKALALYDDMVSHGVKPNEVTFVGLIYACSHVGFVEKGRELFQSMTKDYGIRPSLQHYTCLLDLLGRSGLLDEAENLIHTMPFPPDEPTWAALLSACKRQGRGQMGIRIADHLVSSFKLKDPSTYILLSNIYASASLWGKVSEARRKLGEMEVRKDPGHSSVEVRKETEVFYAGETSHPLKEDIFRLLKKLEEEMRIRNGYVPDTSWILHDMDEQEKEKLLFWHSERSAVAYGLLKAVPGTPIRIVKNLRVCGDCHVVLKHISEITEREIIVRDATRYHHFKGGKCSCNDFW
The following text describes a protein:
Function:
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MLLSKFGSFSHICNTTNIDHLPVKIQLQAAKTEREPFEKVYHVGSVLGSGGFGTVYAGTRISDALPVAIKHVAKERVTEWGTINGSLIPLEIVLLKKVGSTFQGVIKLIDWYERPDGWLIIMERPEMVKDLFDYITEKGALDEDTARGFFRQVLEAVRHCYSCGVVHRDIKDENLLVDLRTGDLKLIDFGSGAILKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEHDEEILRGRLFFRRRVSPVCQQLIKWCLCLRPSDRPTLEQIFEHQWMRTEENPKTAESVNITLHTISTEAGNESL
The following text describes a protein:
Function:
Plays a role in determining ER morphology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.
Sequence:
MGLLWSRFKHKPGTKELLDDIEKKQKSIDEYKYSTERQQKRLVGALIFYSSLFYILCMVITYIWYFPRTVQGQVMCIVPLVLFPVLIVLAKKLLQWYFRRKIERKNEELADLIKQKRTVLDNVMETETYKVAKEILEKYDPETLRKSIKVEEKAGKQLALPEMTDLRRRMPPSKAPLRPARLPHSNLKMPSSSNMPFEERRMMVVPPGMSRNGQQTLGPLPLPRPIFPRERSAFDRVIDFLVGEGPSNRYALICSRCNSHNGMALKEEYEYLAFRCCYCLFWNQAKKQRPEIPKVFELPGSMLALPPPNSSAVVHEDSSASLKSSIPDNADETEMVSCDEGYETKLGKDEGPPTERVLPVDASGDILSPQDVVRQPKHAVVSPLPKNPMAKKED
The following text describes a protein:
Function:
Spindle pole body (SPB) component that acts as the gamma-tubulin complex-binding protein of the SPB outer plaque. Anchors cytoplasmic microtubules at the half bridge of the spindle pole body (SPB) and accordingly functions in nuclear position and spindle orientation, including anaphase spindle migration into the bud. Recruits KIN4 kinase to both SPBs when cytoplasmic microtubules are defective, to delay mitotic exit. Links cytoplasmic microtubules with spindle orientation checkpoint (SPOC) components and, therefore, could function as part of the sensors of spindle orientation defects. Required for cytoplasmic astral microtubule growth during mitosis. Is strictly required for mating and karyogamy.
Miscellaneous:
MISCELLANEOUS: Present with 639 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=localized at the outer plaque and the bridge of the spindle pole body.
Sequence:
MVRRWIPSGRHLRNNDNTGDDDDSEFTNSMDSGMSIPSLRDSMTTRSSHNDPIKPALMNDSNKVKNLEKELTNAKIKIQVLYEYIRRIPNKDGNAPSLGNDTDFRNSIIEGLNLEINKLKQDLKAKEVEYQDTLQFVQENLENSESIVNTINHLLSFILTHFNEQDENAHLLDKEERETLEETLELSSDYVLEKMDTLSKFIIQFLQDFLHSKSRAESKQDKEEFLSLAQSSPAGSQLESRDSPSSKEENTDGGYQNDEIHDSNNHIDTENVMANSTSLPISAVESRFEKTLDTQLEIVIENLHKEYDQFINSIRLKFEKSQKLEKIIASKLNEQSHLLDSLELEENSSSVIEKQDHLISQLKEKIESQSVLINNLEKLKEDIIKMKQNEKVLTKELETQTKINKLKENNWDSYINDLEKQINDLQIDKSEEFHVIQNQLDKLDLENYQLKNQLNTLDNQKLILSQYESNFIKFNQNLLLHLDSIFNILQKILQESSIAQFDRKMKSIKSVPNALKNLNLIQPKLESLYTFIETALESIINSYISSLISMETPEQPHQQGNELTATPNKELTLRIEELQRRWISERERRKLDANASEARIKALEQENESLRSKLFNLSINNP
The following text describes a protein:
Function:
Required for normal growth rate on galactose and mannose.
Miscellaneous:
MISCELLANEOUS: Present with 300 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus.
Sequence:
MSKKLSLEERLSLATKKGRKKNKRSTSNLSSPSPVVLSNNEQESARTSIDDAAAGVVSIDNAENIDDPAVRSESTVEGDTGKADSIAVDDVVHPDHNRTDCFDDTMVSLPTWLPKNYTEFTVEELVKEISPEYLRLNKQIDDLTNELNRKSQIETTDSSFFKLIKEKDDLIDQLRKEGAKLAETELRQSNQIKALRTKVKDLEYEVSELNDSSAQSVENYNELQSLYHNIQGQLAEATNKLKDADKQKESLETLEKNIKEKDDLITILQQSLDNMRTLLEKEKSEFQTEKKALQEATVDQVTTLETKLEQLRIELDSSTQNLDAKSNRDFVDDQQSYEEKQHASFQYNRLKEQLESSKANWDSIEYALNTKIVNLENRFESTMKEKNDIEEKYQTALRSSETLGKQLEKEKENHSKAVLEVKDLERRAETLKSSLQSISDDYNLLKKKYEIQRSQLEQKENELKPHQENSNEKIIDKIPVELTDSLNSMEGNIEDEWTLPQENSMLSLSMSKLGELESDPSLKPIYNESHETICSEESQHFDRKNVDFSIDDIPEEAAALQAIREGESMNSLNNTSIPYRRASVQLSNSNGHISAHLVNKLSTELKRLEGELSASKELYDNLLKEKTKANDEILRLLEENDKFNEVNKQKDDLLKRVEQMQSKLETSLQLLGEKTEQVEELENDVSDLKEMMHQQVQQMVEMQGKMR
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (By similarity). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity (By similarity). The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSMSIDSNKLLLRKGDMKLDNYPTCAVEALTRLETLIASRNKQNMVMQIISEFIFLERTPKDGDVRKSQALPISQMNLFQEFQLIIALIEYFSRPGRDATRNAIFLSLFGSHLTPQRSKLLSRLISTAVSGSVAPLLSSAGTWMQQVGCKTPLSLEVAQNIVSDFISYSRKTPEQLKQLPMVGPHFAANFMVAVADLYLNEQRSPTLNPPPDALLDTITEWMMENPTLCQASQQPLVLPAGAIAMPFTTPLAGLLRWVVLAPLVSNRSAYSNLHLSLLRALQQLVSSGESTALPSQDLMQIVKSLQSYCARLAESKTDPQADAAYQKCMERFAQAVQIALSSNCITNQIQLLCLLESLPPHKLMKIVIEAHKK
The following text describes a protein:
Function:
Involved in biosynthetic vesicle transport to lysosomes. Acts as a cell growth regulator. Also has a crucial role in controlling organ rotation by regulating membrane-localized Notch receptor endocytosis and subsequent degradation. Regulation of organ rotation is not by induction of autophagy.
Sequence:
MNLRPRCRKWLPLATQQLRLRNLNRIQGFNIESWPHEKSLELDDPDDVLLYYTLHTDKASEAFYTSEKLPQRHQQQKWAEICTDDEAWRKTNAQCVCVKVWKHYSAERRDGQPPEVEQRHKDVFGRSQLTPSRLPRPPELLFSWGVYFSGLIPLSPLTLSQCGRNCLVFQLNGEQFASPSMISEQALQSQLHLHYQKYAEEEKLEEPQDEGINSPAVSRSSSPVLRMSTMRYAQLKCQRQEIRRSNNLEKLLTLQRLQRLHQQKRRQMAEVCREIARLSVHCVTRNELRLKPRTTSLSGDYSAHQYHSMGRALSVLLAEQQQIAPLTLYNAQQLTRRIEALSSQQRLLKAERETFRQRNERTRQLLKEMREQREAQQWELHSQRHRLEKERLELRTLAPQHLEQRDQKRQIERQVERRMSTLVLELQEIYNIQNVGGRQFSICGIAFPHMEQYTSESRQAANAQLLDNVSPLAVSAALGYVAHLVQMLAIIMDRPLRNRILYEPSKARIVDDIKELTYTTREFPLYTRSILPSQQTKYAIYLLRQNVSQLCFDITGQCDLRNTFGNLLELFSTLRYIERTQRDEVDERDGTAVGAGCGEARLANGLTAPHLSQSHSSVDMNHVPLPTGVNAVKDALLQQLLPPGVSEALAIEGYASTQRICRSVGSYSDGEDEFRPRLEHNYSNSDSNITLQTERS
The following text describes a protein:
Function:
Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
Sequence:
MEVLVEFDYEALHDDELTLRPGDVIRNVRYIEEDGWMEGDLNGKRGVFPDNFVKEIKKEKEPKEVKETKHEPKEETSVPQKREKSAHVANLVQRMSTIGFPTGGFQPPTTVKKPKKRHCKVLFDYQPQNEDELELKKGDLIEITEEVEEGWWSGSLNGKSGLFPSNFVKEMDAAGEDVESSDATPDDAEGSGTDGATTPTSPQSASGSGAIAQPKKVQRFGYGDIFKESSFKLKPVPSLPSSAKPTPPNTTEPPRAEADAKLKDASVSVPSAKEFCRVMFAFEGTHEDELSLKEGDIVQILSKDTGETGWWRGEIGGERGVFPDNFVVVISETERESLMSRGSIKSSPKQELDPKRKKPPPPTKATGPRPDIPFTDRKPHPIKPEEKVERPSPDIKTHKPAPVVPPKKPLPPGKNKPASFPPKRPEKTFVPSASFRENGEVSSSRQKPEVEPLAPSKPKPLAGNMEEKPPEGTKDQLQPAPQTQAPPASDLMSFDDLSAASEKLSHPTANRPKMLGRRPPTQFVAEKSPTKDTIVEKFFRPEDEEAAKPKLTETRKPSINSLSPLLSRPAEAKAAPATSPGVDANASQSGKARLEPEEPNAQLEDLRGQIKDLLLTVELLKVQQTKEISELRVELDEERLKRLTLQMEIEKLKKAIHLT
The following text describes a protein:
Function:
Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 26 nm in diameter, and consisting of 89 capsid proteins dimers (178 capsid proteins). Involved in viral genome encapsidation through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome. Binding of the capsid proteins to the viral RNA induces a conformational change required for efficient T=3 shell formation. The capsid also contains 1 copy of the A2 maturation protein; Acts as a translational repressor of viral replicase synthesis late in infection. This latter function is the result of capsid protein interaction with an RNA hairpin which contains the replicase ribosome-binding site.
Subcellular Localization:
Virion. Note=The shell is composed of 89 dimers of the capsid protein, one of them being sequestered inside the virion, and 1 copy of the maturation protein.
Sequence:
MAKLETVTLGNIGKDGKQTLVLNPRGVNPTNGVASLSQAGAVPALEKRVTVSVSQPSRNRKNYKVQVKIQNPTACTANGSCDPSVTRQAYADVTFSFTQYSTDEERAFVRTELAALLASPLLIDAIDQLNPAY
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region.
Sequence:
MGDSRDPCPHLDSIGEVTKEDLLLKSKGTCQSCGVAGPNLWACLQVSCSYVGCGESFADHSTIHAQVKTHNLTVNLTTFRVWCYACEKEVFLEQRLAAHPPGPLPKFSEQDSPPPPCHPLKAVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNPPLTQFFLECGGLVRTDKKPALCKSYQKLVTEVWHRKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPRVAAALPEARDSDSSDSDEKREGDRSPSEDEFLSCDSSSDRGEGDGQGRGGGGSPAETELLIPDEAGRAISEKERRKDRFSWGQQRTSSEQVDEDADVDTAMAALDQQPTDTQPPSPRSTSPCRTPEPDNEAHMRSASRPCSPVHHHEGHAKLAGSPPRASPVRMGPSYVLKKAQVPSTGSRRRKEQQYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLQLPEILCIHLKRFRHEVMYSFKISSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETLVQNAEAYVLFYRKSSEEALRERQQVVSLAAMREPSLLRFYVSREWLNKFNTFAEPGPITNHTFLCSHGGIPPNKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVCSICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPSVIYCISMQWFREWEAFVKGKDNEPPGPIDNSRIAQVKGSGHIQLKQGADYGQISEETWVYLLSLYGGGPEIAIRQSVAQLQDPESLHGEQKIEAETRAV
The following text describes a protein:
Function:
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Might be able to function at relatively high concentrations of Na(+) ions. Also has Li(+)/H(+) antiport activity under K(+)-rich conditions, but it might not have any physiological relevance.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDTAVNESLSISYNLEQFLIVLSVSLSIATLSKTVPILRKIPYTLLLVIVGMALAFVDVKLINLSPELIMEIFLPPLLFEAAWNLQWRNLKENWFPITLFATLGVVICVVGIAFPLSYWGGMELAIAFLAAAALSATDPVSVIALFKELGASKKLNTLMEGESLFNDGVAVVVFLILVGIPLGTSTFDLSVTLARFVTVIGIGVGCGLVIGFSLSLLTQRFDLPFVEQSLTLVSAYGAYILAENLGGSGVIGVVVVGMVLGNYGSRIGMNPRTRLIVSIFWEFVAFFVNSIIFLLIGDQIGLSSLSDHLNLILIAIAAVVVTRLVSVFGLSLISNKVSDQISSTHITLQEQTVLWWGGLRGSVAIAVALSVPQAIAERQAIIDIVFGVVLFTLLVQGLTTQFVLKGLDLIGDQPQRLEYAELVSRQIALRRVLAELEKTDEFPDINPERLRYKQELVQGQLQSVTDKLKLLLQEYPLLQEVANKKFDQTVLDIEAETYADLIRMGRLEENIMPLLVTLEGENVAEPS
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
TTRHWDLNKSFVYKNVSLAMQKIPDEEGATPSRAPGVVAASGAAEGDDGGGGSGAKNSASGNSNNNASGGGIIVLRAALGENEARAVINKWRVREGQFVSAAQILFLYQPVGVDAKDAGKPGGDCAIQRYKSQRAGVVKKRLRKEGELLTKGDAILELSECIHTTVIKDMCADCGADLRQNENGQTSEASVPMVHTMPDLKVTQKLAQKLGHDDTRRLLADRKLVLLVDLDQTVIHTTNDTVPDNIKGIYHFQLYGPHSPWYHTRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGKFFSHRILSRDECFNATSKTDNLKALFPNGDSMVCIIDDREDVWNMASNLIQVKPYHFFQHTGDINAPPGLSKHELDGEGVDFKEITEKHGDKDKTESSSEVKPEDTDKGDNTVTSTSKDDDVNEESVDVFEIEGDAKDPEVSNASSATEAPKEPRDKLNGKTNAEDIVVIDDSSSGSPDAEKAASDGEDVVVIDDNSKESTKAEVPPTPAEKNEVVASSTTSPDEKRPSADADVATTSKTPSLRAPLEGQKQIEIEDPDDYLLYLEVILRNIHKRFYSIYDETTEIPDLKVIVPKIRSEVLRGKNLVFSGLVPTQMKLEQSRAYFIAKSLGAEVKPNIDKEITHLVAVNAGTYKVNAAKKEPAIKVVNANWLWTCAERWEHVEEKLFPLDRKVRNKGRQPPAHCHSPEHVVNYSERSEISPSSSKQQEEQSGNFRETLNPLLVFTNADIESMNKDYETFFESDSSSDEGPVNFENPPMDKKLLKRKREDDNSNRAHDFFTRSDDIMIGAPNLVEVDISSNEEADDNNEKEDDDDEMPSAKFRRGEDLPSDLELGSESNSEKEPEDEDDGEWNMMGAALEREFLGLEDFDM
The following text describes a protein:
Function:
Probable transcription factor. Involved in embryonic development and in vulval development in larvae, acting redundantly, at least in part, with elt-6. Perhaps acting together with elt-6, may form a positive feedback loop to initiate and maintain lin-39 gene expression to ensure proper vulval precursor cell (VPC) fate specification. Together with elt-6, acts as a downstream target of the Wnt/beta-catenin asymmetry pathway, required to adopt or maintain the seam cell fate. Required in seam cells, acting redundantly with elt-6, to promote production of alae, expression of several seam-specific genes and maintenance of seam cells in an unfused state. Plays a role in longevity. May form a transcriptional circuit with GATA factors elt-3 and elt-6.
Subcellular Localization:
Nucleus.
Sequence:
MSISIMTETRPESAEQQHHEVLQRPSDEPCSGCKQLQKDVAKTISMVMERMDKLQYRLDELLKENNELKSSSVSSGKASPSPAESRSSPKLVETVVAPVSGARKRKPKERSPPAAASPLPDFSNLMNGFMFDPLNMSNPNGMMQLLSMVQQQQQQQQHHQHIENQQSVSPPQSKSVKIEDPMDQDVKQEESERSDIPTATEAQNLLDALTAQFSSNGQATSTTSPPSSSSQVQAVIEAVATPSSQSQDSSMFEKTETSGDPNAARCSNCRTDKTTAWRRDAEGKLVCNPCGLYYRLHKVRRPIEMRKNHIQQRYRRKNKEKESSAATQIFNQLLTQMPTMATGGVSTDGAINTFNLLEQISQFTQAQELMNSSATF
The following text describes a protein:
Function:
With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).
Miscellaneous:
MISCELLANEOUS: Present with 8970 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
METDSGIPGHSFVLKWTKNIFSRTLRASNCVPRHVGFIMDGNRRFARKKEMDVKEGHEAGFVSMSRILELCYEAGVDTATVFAFSIENFKRSSREVESLMTLARERIRQITERGELACKYGVRIKIIGDLSLLDKSLLEDVRVAVETTKNNKRATLNICFPYTGREEILHAMKETIVQHKKGAAIDESTLESHLYTAGVPPLDLLIRTSGVSRLSDFLIWQASSKGVRIELLDCLWPEFGPIRMAWILLKFSFHKSFLNKEYRLEEGDYDEETNGDPIDLKEKKLN
The following text describes a protein:
Function:
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEQKGSLVSRANSIGSTSASSVPNTAYNMMDNACSLTSDDEDSDDRQGTIKNDYKDRRRRAHTQAEQKRRDAIKKGYDDLQCIVPTCQQQDIAIGTQKLSKAVVLQKTIDYIQFLNKEKKKQEDDVSKLRKEVMALQIMKSNYEQIVKAHQNNLHEGTDQVPDEMKFRVFQGIMDSLFHTFNSSVSVNSFQELSACVFAWIEEHCKPQTLQDIVIRFLHQLKNPLY