lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Lipid transfer protein required for autophagosome completion and peroxisome degradation. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region. The latter binding is assisted by an ATG18-PtdIns3P interaction. ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MSSWLPQNVQKRLLIYLLQQISIFSQIDTTNLDVSLGCRSQFAFHDVELNVDHMRVPHITVESGHISELELGLVVSGGLDITGDGLCFVVRPELSEVAGSHDLAQSLARSIMDLTNSMMQPLPEVLEGDEVLANSCSEAGDAQQPASSSALDKMRNKVLERALSNLTVRIINVRIQVLFPGQQSITVLVGSVELSTVDKTRRVDLQDICISHSELVPSPEQPDEFMSTSASNSIYMSAIDSLPFGSRSKMEENARNVRALLQMDKLHVTFQGISSVEDISIRDLMLHMGRVDVFLDAIIAVDIGVFEVLVQFVAEFQQDTEVSETSNTLQNYKRFRQEQNLEEDLQITGFTIEELRITLSQSVKVSVIDIQLRNRYIENSTVTVGRVTICDYDLDLLHIDAGSKPCLELTVDSRKLQRIISVDGDIHMDISSTFVSSLIPLIFRLQELGRGLHFVGTNNCKMSQEFKTQVETKTIILSLPVGDDTLQMIIQPISYELSLHTVFTDFISISKVQSSETRDIAIIREIKIGYQTANFQVKSYNLKLSETLLTSKLRGSVSSVELYCSDSDIKWLFDGLSPYQDMITPYMHSKPEVRKPIMNKSVRILSASSVIHRQNVFSDMVLLIERITCSLSADSISSFGNVKTELNSSLLSLNTDNSIIFHSSCVKGSTVFSDVKYCLFEPIKTKDVTKPALFVQRFENGKLKVNVQNTCIYYHAKWLDILDESKGTKSTPQQESAVPVPLQQRIEVKFHDCALSMHPYRLKSALLICVNRCILDISVPPANFKCIIRSPTFMLADDCSNMKTSITESWESLVRYYSKAGFAVIGKSGLLSCTIKQSGGQICLDIDVDRIDLSICADSFQCLIQTLIDIKPPVSFPDEKKYRTEPCSIPVFENVDDEFFVPKGTSNLPALNDMHIVDDFINNSNNSFSEVQVIEETEEGSPLKLEDNGLLFDEGHFNKEDIPVATDSKFFPFGPVAIVLHLFVRKASIKLHDGYDWVYTRRSISKVVDDLEDEVHKQDQPGRVETSLFDSIYLYATPDSNIKKAVSSNIQSEDIIAENYSSKMKLRPSKHHKILIELTNMKLTFSGYSYDEPTEDIADWSTDLLNSIDVEVKTFEIVDNVATSTWNKFLTELKEAHGGSPSMLALSISLVRPIDFLYATELIISAQVSPLRLHVDQDTLDFLIRFSEFKDARFDLIDDYPDIVYIQRFEVNSIDVKLDYKPKKVDYVGLKSGHTSELMNFFTLDGAKMTLKRVVLYGVDGLGELHNCLSSIWTPDITRSQLSGVLKGVTPLKSIITLGSGVKALVTVPLKEYRQDQRLTRSLQKGARDFLKTTSGELIRLGVRMASGTQAILENTEEFFGGQGARARCMSARLPEDELSPVPSACDEFDLFRSSIPRKQSPIVPIPSEEDDIEPLKAISLYADQPQNAQKGVKEAYGSLGKNLTIAYGAVRRAQRDARHSISAQDAATAFARATPIAFIRPMIGATEAVSKTLQGISNQMDRDQLVHMRDKYKQSSHYQRKRER
The following text describes a protein:
Function:
Acts as an effector of RABF2A and RABF2B. Involved in vacuolar transport of storage proteins. Regulates membrane trafficking to protein storage vacuoles (PSVs). Binds specifically to phosphatidylinositol 3-monophosphate (PtdIns3P).
Subcellular Localization:
Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein.
Sequence:
MERRGSPPKHRHDGTSPLPLGMDWSPPPKKWNGRDTIWPHDPRTGWSYCITIPTWVVLPKSRDSDPVVFYRVQVGLQSPEGVTTTRTVSRRFNDFLRLLAALRKAFPKKNLPPAPPKGLLRLKSRTLLEERRCSLEEWMTKLLSDIDISRSIVVASFLELESAARSSFQDENPQIGESSATVSSSPHIHPNESESTPDYNSDTAYDETSEIGTSRDNISEDLSLDEDLVGPLEKLVKHGVSNIDEGLLMGNAILDQVEGYSRNTNHSREINMKGSSSSSSEKNGDYVSEKFFNGNNEIIKESNDVKNLVLPLGQQQKMNRVVVSMKRRLGTAKTDMEDLISRLNQEIAVKDYLTTKVKDLEEELETTKVRSKENLHQAILMERERVTQMQWDMEELRRKSLEMEFKLNSQSQQDEKVEMKSVIEEKDELLQELEDTKSKLEQVSKKHQELEIKSKADVKILVKEVKSLRTSQAELKQQLNQSLIGKSEAEKLVQQEKERMEEEKAGRMKLLHECDVLQKRLKECSMNLVINGSSEDKLVICSPSVEDALQLVKISDDRMEALLAQAQMLAEDDSFDDGDNPTNNNNNKLRKILSEILVDNITLRRQVSLLFDGALKTGVITTTTTTKDMEVSLDKS
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPLAEKLDRKLRPADDSSDGEDYYEVTDRSSSESILETANANKDDASDDERVKSQMSKVSFGALAKAQDALSKQQSADRKRKRGEDTSKSQDDKLEALRERLRQIKAEKMANGAAGAKPKKKSEGTKKGKVIQDEDDEDDDEEDVDSDNSDTEAAPKARSSKHAPMVQSSKRMVSRKRKVVDVKKPVFRDPRFDNMGGAAPDDNTLGNRYSFLNDYRASEIAELRRTIKKSKNEGEKERLKKQLLSMESQQKARENKEKHQEVIREHKKKEKELVKQGKQPFFLKKSEQKKLALIDRFQNMKSKQLDKVIERRRKKVTSKERRNMPERRTA
The following text describes a protein:
Function:
Catalyzes N-methylation of phosphoethanolamine, phosphomonomethylethanolamine and phosphodimethylethanolamine, the three methylation steps required to convert phosphoethanolamine to phosphocholine. Has no ethanolamine- or phosphatidylethanolamine-N-methyltransferase activity. Required for gametocyte development, maturation and transmission to mosquitoes and for oocyst formation in the mosquito midgut.
Miscellaneous:
MISCELLANEOUS: Synthetic inhibitors of PMT block gametocyte development.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
MTLIENLNSDKTFLENNQYTDEGVKVYEFIFGENYISSGGLEATKKILSDIELNENSKVLDIGSGLGGGCMYINEKYGAHTHGIDICSNIVNMANERVSGNNKIIFEANDILTKEFPENNFDLIYSRDAILHLSLENKNKLFQKCYKWLKPTGTLLITDYCATEKENWDDEFKEYVKQRKYTLITVEEYADILTACNFKNVVSKDLSDYWNQLLEVEHKYLHENKEEFLKLFSEKKFISLDDGWSRKIKDSKRKMQRWGYFKATKN
The following text describes a protein:
Function:
Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection.
Subcellular Localization:
Secreted.
Sequence:
MKLTFFLGLLALISCFTPSESQRFSRRPYLPGQLPPPPLYRPRWVPPSPPPPYDSRLNSPLSLPFVPGRVPPSSFSRFSQAVILSQLFPLESIRQPRLFPGYPNLHFPLRPYYVGPIRILKPPFPPIPFFLAIYLPISNPEPQINITTADTTITTNPPTTATATTSTSTKPTMTISSSTVPISSTPEPATSISAATPAASTENTTQILANRPHTVLLNATVQVTTSNQTILSSPAFKSFWQKLFAIFG
The following text describes a protein:
Function:
Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
Subcellular Localization:
Nucleus.
Sequence:
MATVSEDDLSEQFETFGVTLDTNDPDIVDKLKELCLLYRLTAEDAVAEWIAFSTTHSGLAINMDTLEQLERETLSKKSSKVKTPSSRKPAGKQTSFAMLDDDDESEDLLDAYTPGPKARQKKRVMTTPDNVSSKRTPLREHNIKKEEDITSSAGSPSLTATPSQKYSSRSKSGEVVASFGPVTTVIWEGSNLTNCCVSRGQVDPCMKNSDKYKYMMQKMKKKAEVLNEMIEDMSKTLQEKHNIESVSHLALPIQEPETVVGRICCDSNGRLNAQSVMMEGSVETSAGKQVAVSLAEVKEYSLFPGQVVAMDGVNSAGVKFVASKIYPGVAGEFKPTDCSEATGNLHLLVAAGPFSTSDNLSLEPLEDLIKVIKKTRPDACILLGPFVDVEHGQIKDGSLGESYDKVFSDIVQAIVRKTESVGCELIFQPSLRDAHHHFIYPQPPYSEIKNQPKRVHFVAEPEMININGINIATTSTDILFHLSREEISCPPGSSDRLGRLVRHILTQHNFYPLYPASEEVPVDYEKFHQYGKMGCAPHIFVCPSRLRFFVKEIESAVCINPGLLTSGQVGGTYARLVVKNTGPGNDEKTDNKAVNRTAVEIVRI
The following text describes a protein:
Function:
Snake venom endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. In venom, it is not toxic by itself, but increases the diffusion of other venom proteins by degrading the extracellular matrix. In addition, it displays antiedematogenic activity.
Sequence:
MSPKLRSGGVTHNVETLCSAGPSQRTSIHLRLHKHFLLLLLLFPDLPAASYNLKPSLPPIIKNNPFLVTWNAPTARCSAAYEVPLNLDSYGILVNSQEAFAGGNITIFYYDQLGLYPYYLDTTVPPTAVNGGCPQNSSLTEHLDKMKSDIGNIIPSESFAGLSVIDWEHWRPQWIRNWDKKMIYRNMSLQLVRKWSPNLSDPQAEMKAKWEFETAAEKFMLDTLRLSQSLRPNGWWGYYLFPECYNYQYLENFANFTGHCPPLEVERNNKLIWLWENSKALYPSIYMEEVLRTSLQGKRFVWAKMGEAMRVAELPSTQHSLPVFVYARPFYTYTLKELTQTDLEYTIGQAAAMGAHGIVLWGDADYSRNRTNCLKIQEYLMSTLGPYILNVTTATKLCSQNLCNNHGRCVRRKMDSDSYLHLSPSSFQIQTSMEGNQTKVSVTGSLTPQQKDKMWQEFTCHCYLGWSGESCSSRGQGLRLQTCSFCIPGMILAVLSMWHL
The following text describes a protein:
Function:
Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.
Sequence:
MEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGPIRGWKSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVITLKAATKQVMLYWLQQLQMKRWEFHNSPLAPPATPDAALAGNGPVLHLELGQEEAELEEFLCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNTMHNIRGNKQAQGTGHEPPGEDSPQSGEPQREEQPSASDASTPGREPEDSPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITRNRTAQEKVAALEQQVLMLTKELKSQKELVKILHKALEAAQQEKRASSAYLAAAEDKDRLELVRHKVRQIAELGRRVEALEQERESLAHTASLREQQVQELQQHVQLLMDKNHAKQQVICKLSEKVTQDFTHPPDQSPLRPDAANRDFLSQQGKIEHLKDDMEAYRTQNCFLNSEIHQVTKIWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEALGDEASECSELLRQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQLKAEYLERQASRRRAVSEGCASEDEVEGEA
The following text describes a protein:
Function:
Together with AlgJ and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization-transport complex and adds acetyl groups at the O-2 and O-3 positions of mannuronate residues. Acetylation of alginate is important for the architecture of biofilms and increases resistance to opsonic killing in the host.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MVFSSNVFLFLFLPVFLGLYYLSGERYRNLLLLIASYVFYAWWRVDFLLLFAGVTVFNYWIGLRIGAAGVRTRAAQRWLILGVVVDLCVLGYFKYANFGVDSLNEIITSFGMQPFVLTHILLPIGISFYTFESISYIIDVYRGDTPATHNLIDFAAFVAIFPHLIAGPVLRFKDLVDQFNHRTHTVDKFAEGCTRFMQGFVKKVFIADTLAALADHCFALQNPTTGDAWLGALAYTAQLYFDFSGYSDMAIGLGLMMGFRFMENFNQPYISQSITEFWRRWHISLSTWLRDYLYISLGGNRGSTFQTYRNLFLTMLLGGLWHGANFTYIIWGAWHGMWLAIERALGVNAAPRVLNPLKWVITFLLVVIGWVIFRAENLQVAWRMYEAMFSFGTWQLSELNRANLTGLQVGTLVLAYLVLAFFGLRQFYNQPLQTKAPKAAANSDEVAADGPASAQPRAPREAAGDPAAIAYSPSGALVYQPSWLSQLPVLATRLALLLLFAASVLKLSAQSYSPFLYFQF
The following text describes a protein:
Function:
Plays a role in the adhesion and fusion of the sperm-oocyte membrane through its interactions with IZUMO1 and IZUMO1R/JUNO (By similarity). When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation.
Subcellular Localization:
Vesicle. Cytoplasm. Cell membrane. Note=Aggregates in vesicles when cross-linked.
Domain:
WD6 repeat is required for cross-linking by TGM2.
Sequence:
MFRWERSIPLRGSAAALCNNLSVLQLPARNLTYFGVVHGPSAQLLSAAPEGVPLAQRQLHAKEGAGVSPPLITQVHWCVLPFRVLLVLTSHRGIQMYESNGYTMVYWHALDSGDASPVQAVFARGIAASGHFICVGTWSGRVLVFDIPAKGPNIVLSEELAGHQMPITDIATEPAQGQDCVADMVTADDSGLLCVWRSGPEFTLLTRIPGFGVPCPSVQLWQGIIAAGYGNGQVHLYEATTGNLHVQINAHARAICALDLASEVGKLLSAGEDTFVHIWKLSRNPESGYIEVEHCHGECVADTQLCGARFCDSSGNSFAVTGYDLAEIRRFSSV
The following text describes a protein:
Function:
Histone deubiquitinating enzyme component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs). Within the DUB module, the correctly positioned zinc finger domains of sgf11 and sgf73 are both required to fully activate the ubiquitin hydrolase ubp8. The DUB module is also linked to the splicing efficiency of many transcripts.
Subcellular Localization:
Nucleus. Nucleus, nucleoplasm.
Domain:
The UBP-type zinc finger domain is required for the interaction with the SAGA complex; The USP domain is the catalytic domain, but it is only active when in complex with the other DUB module subunits.
Sequence:
MPGDVEGCQHLKLKPADVENYQKICTQIFSCHFVPRRCSTCKRINKRSIRCLSCHSVGCLWGHHGEEHAMEHTHMIGVDVKNGHTYCFGCQDYVYQTELETLRFKIKNIKAWQSDHKRLPEKYNQMVCLEAYRKYPPVCATAGLRGIQNLGATCFMSVILQSILHNPLVRNLFFSGFHTSTDCKRPTCMTCAIDDMFSSIYNSKNKSTFYGPTAVLNLMWKLSKSLCGYSQQDGHEFFVYLLDQMHTESGGGTSMPCTCPIHRIFSGSLKNVVTCLDCKKERVAVDPLMDISLDINEPTLQGCLERFVSKEKVQYSCHSCGSKNAIKQLVFDKLPPTICMQLKRFEQNNFAMSTKIDKQVSYPAFLRMRYNFNQDDVDYQLYSVVCHKGTLDTGHYIAYTYYQNQWFLLDDTTIVEVKESEVLNSQAYLLFYHERQILYSDEMTVKTEN
The following text describes a protein:
Function:
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MNSSSSHRNILVTSALPYANGPIHLGHVLEGIQTDIWVRFQKAIGNECYFFCADDTHGTPVMLAARKEGITPEQLIERVGQEHYRDLTSFGIEYDHYDSTHSKANQEISKDIYLKLKSKGHISRRSIEQSYCETDKMFLPDRFIKGTCPNCKSKDQYGDNCEVCGATYSPKDLIDSHCSLCGTSPVVKNSDHIFFKLGDFHKKDEKSTSLETINPSHLKTDFDLQSWIETSGVVSESEGVKKKLKEWFDAGLQDWDISRDGPYFGFEIPDETNKYFYVWLDAPIGYMASSKNFFEKNFPNEPNKFDSFWKNKNSEIVHFIGKDILYFHTLFWPAMLEGSDYRAPSKVHVHGFIGVNGEKMSKSRGTFIKAETFVKYLDPEHLRFYLASKLGPGMDDIDLSFEDFINKVNSDLVGNLINSVSRVSTTILDALDRTLGVVSKEGLALIEEILYQTVKFGPGEDSIQNIIKYAYDQRNYAKVLREITRLGDRVNRYVNDNAPWKLIKENPEKAREVVTVTLNASRFLAIYLYPVVPKISEQIYKLLNLQDSPSFKDLDKNRILENIKVLPYEMISKRVDEKAIKAMLEENKQSEHSKKVETSENPVPEERLEISIDDLSKVELRVGQIVEAGPVDGADKLVNVKVDLGELGIKNVFAGIKVAYQPENLKGLKVVVVANLKPRKMKFGISEAMLLASGEGESLSLFIPHKDAKPGDRLK
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MPMFQPLKRDGLIGFEGGGDGQVLDLDTAVKDGVLGGVNGGGVGVVDEKLDLKKMIKELDLQDIPSVFICPISLEPMQDPVTLCTGQTYERLNIHKWFNLGHLTCPTTMQELWDDTVTPNKTLHHLIYTWFSQKYVLMKKRSEDVQGRAIEILGTLKKAKGQARVHALSELKQIVIAHLMARKTVVEEGGVSVISSLLGPFTSHAVGSEVVAILVSLDLDSDSKSGLMQPAKVSLIVDMLNDGSNETKINCARLIRGLVEEKGFRAELVSSHSLLVGLMRLVKDKRHRNGVSPALRLLKPISVHKQVRSLMVSIGAVPQLVDILPSLDPECLELALFVLDALCTDVEGRVAVKDSANTIPYTVRVLMRVSENCTNYALSILWSVCKLAPEECSPLAVEVGLAAKLLLVIQSGCDAALKQRSAELLKLCSLHYSDTMFISKCKLTRTIQ
The following text describes a protein:
Function:
Large subunit of the DNA topoisomerase that untwists superhelical DNA. Controls of topological states of double-stranded DNA by transient breakage and subsequent rejoining of DNA strands.
Miscellaneous:
MISCELLANEOUS: Binds both single and double-stranded DNA.
Sequence:
MIKNEIKILSDIEHIKKRSGMYIGSSANETHERFMFGKWESVQYVPGLVKLIDEIIDNSVDEGIRTKFKFANKINVTIKNNQVTVEDNGRGIPQAMVKTPTGEEIPGPVAAWTIPKAGGNFGDDKERVTGGMNGVGSSLTNIFSVMFVGETGDGQNNIVVRCSNGMENKSWEDIPGKWKGTRVTFIPDFMSFETNELSQVYLDITLDRLQTLAVVYPDIQFTFNGKKVQGNFKKYARQYDEHAIVQEQENCSIAVGRSPDGFRQLTYVNNIHTKNGGHHIDCAMDDICEDLIPQIKRKFKIDVTKARVKECLTIVMFVRDMKNMRLIRQTKERLTSPFGEIRSHIQLDAKKISRDILNNEAILMPIIEAALARKLAAEKAAETKAAKKASKAKVHKHIKANLCGKDADTTLFLTEGDSAIGYLIDVRDKELHGGYPLRGKVLNSWGMSYADMLKNKELFDICAITGLVLGEKAFEEKEDGEWFTFELNGDTIIVNENDEVQINGKWITVGELRKNL
The following text describes a protein:
Function:
Part of the homotypic fusion and vacuole protein sorting (HOPS) tethering complex involved in endo-lysosomal vesicle trafficking and lysosome biogenesis. The HOPS complex facilitates docking and fusion of lysosomes with late endosomes and several other types of vesicles. The HOPS complex is also involved in autophagy and crinophagy (the elimination of unused secretory granules through their fusion with lysosomes). The HOPS complex mediates autophagocitic flux, probably by binding autophagosome-associated Syx17/syntaxin 17, promoting assembly of the trans-SNARE complex and instigating autophagosome-lysosome fusion. Independent of Syx17/syntaxin 17, HOPS is involved in biosynthetic transport to lysosomes and lysosome-related organelles such as eye-pigment granules. Required for endocytic degradation of boss/bride of sevenless and N/Notch in developing ommatidia.
Miscellaneous:
MISCELLANEOUS: The name 'light' was given due to the eye color phenotype caused by hypomorphic mutations in the lt gene.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Localizes to a subset of Rab7 positive late endosomes probably consisting of mature endosomes ready for fusion with lysosomes; this localization is dependent on Rab2 and Rab7 and a fully functional HOPS complex and prevented by Rab5.
Sequence:
MAKALPLISCDSWADSINEEDVEPKFKYHRLANDLKYMLNADVITCSAVHLKFLIFGTFRGRVCIFDHQGNSVYSNLSASERHTHQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNNHSLSFGKFIKVVSLEPDSKAHIKRFVVGDDKLILYERNLLKKLKPVELCSVEGSVLSICWHGNFIAWASHIGVRVYDLNERCSLGLIKWEVPPQERLENFRCHLRWSNKHTLLIGWVDTIRVCVIRKRNSIEASTGNLPVYIVDPISTFQTTFYVCGLAPLSAKQLVVLGFRKEKSSCFKALRPVLCVIEYKMNNSEEICTDSLTLRGFEEYTVNDYSLGGIIEENRFYIVAPKDIVVASLIETDDRIEWLIKHSKFEEAMELISANGGNVPVLSVAKLYINHLLALKKYDDAAKLCLRMLGNDKVLWEEEVFKFVKCQQLRSVSAYLPTSDECKLDPHVYEMVLYEFLKFDVCGFLNLIKEWPSHLYDGLAVINAIHDNFRKHYANQLLESLALLYSYQGDFESALRMYLKLQNKDVFQLIRRYELYDVISKLIIPLIQLDRDCAFEILLDKKKIKTEIVVHQLEHNQEYLYWYLDSLLKKDPSNVFQKKLISLYAIFDRNKLLPFLKRSKDYDIQEALVICKQENFYPEIVYLLGCMGGVEASEALNIIIHRIRDIEMAIEFCKEHDDSDLWNALINEFSKHPEIVTKVLDGIVDYFSPAVVVGKIKMGQNIPNLRQSLIKMLRHYNLQGEILSSAQQIQLNDYFEIHSEIVTTQRRGQQVSYEQLCSLCHRPVLMAGTHLYCIIRLECGHVYHKPCIQGELLKNCNECNLWKLTVGK
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MVGTMNEQKISGYFKDKSILITGSTGFLGKLLVEKILRVQSDVKKIYLPVRAPDAAAAQQRVETEVVGSELFGLVRQKHGDGFESFMRDKIVPLAGDVTLEDFGVHEETLKELRLPQELDVIVNVAATTSFYERYDVALDVNVLGVKHMCNFANKCPNLKVLLHVSTAYVAGENQGLVQERPFRYGETLCNGPPLDIDTELNLARELKKQMETDCDMDPSPQAQRKAMKDLGLTRARYFGWPNTYVFTKSMGEMMIGQLLKGEFPVVIVRPSIITSVHKDPLPGWIEGARSIHAVLIRYIKQNQTWFIADPDLTADVIPGDMVVNAMITTMVVHAYYSLENTSKSHLNPSFPAVYHVSTSLSHPVQCSVLYKAMLRYFKEHPVAGPNGRIVPTRKIRFITSIFLFRLFMVLWYRIPIELLHLISILLCGLFGLNVLYHDLIRNYSHAMQLVDLYGPFALFKGRFDDINLNRLRLRLTMDSEHGGLFNFNPKTIDWDDYFYRIHIPGIMKMEK
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome; Forms part of the polypeptide exit tunnel.
Sequence:
MVLLSKFDFSGKESGKFELPDAFFTEGKEQSVKDYLVAIQANKRQWSACTRGRSEVSHSTKKPFRQKGTGNARQGCLAAPQFRGGGIVFGPKPKFDQHIRINKKERRAAIRLLLAQKIQTGKLIVAENSVFVSSLDAPKTKEALRFLKECNVECRGVLFVDGLAHVGSNENLRLSVRNLSAVRGFTYGENISGYDIAAARNIVVSEKALELLVESLVSTTKD
The following text describes a protein:
Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKALRCWASFFFVLLATWETALSVTRYSIPEEMERGSVVANLAADLGLDVSGLAQREVKLDIFHSKKYLDINKRTGELFIVEKMDRETLCPAKTTTCFLKLDLIIESPLRMFNIELGITDINDNAPHFRRDKIELDVSESASPGERFSLPNAFDPDVGANTVKTYKLSENEHFTVDIHSGSDGTKYVDLVLMKALDREDKAVHNLILTAIDGGVPARSGTASIIVRVQDTNDNAPQFDQALYSLNISENSPAGTVVVKLNATDADEGPNADLTYSFTLYTSEKTQEMFSLDSNTGEIAVKGTIDYEDMKIFEMFVEAKDNGPVPLSGQSRVSVYVTDMNDNYPEITIKSLKNTVDENIPVGSVIALVGVSDRDTGDNGKVNLTMNRALPFLLNQSSDHLYELLVSKPLDREVVPEYEITLVVTDKGNPPLSDNETITVHLLDVNDNAPQFPQTFYTIPVKENNAPGALLGSITAIDPDLNENQYLVYFIIEREIANTSMSMLFSINPENGNLYALKTFDYEIEKDFLFHIEARDSGVPPLSSNVTVHIIIMDQNDNTPLIVSPWRAQGSEVKETIPRSTDKGTLIAKVIAIDSDSVHNSRITYQFLQNTDATLFSLDQYNGEIRTMRMFSYRDSRDQRLVVIAKDNGEPALSATVTIKLSTVETALKTYTEVPLEYDIFSDLNLYLVIGLGSVSFLLLITILVTIVLKCQKAKPSKAAPPSRNSVISERNSTIADSTLVSNDAYWYSLFLAETRKGKLVVRQPVPKGARYIVSSIPRSTGLTETSDSAASTLQVRKLLIIVCYETAIMHTIYCAILKCT
The following text describes a protein:
Function:
Calcium-dependent mitochondrial solute carrier.
Miscellaneous:
MISCELLANEOUS: Present with 1170 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MLLKNCETDKQRDIRYACLFKELDVKGNGQVTLDNLISAFEKNDHPLKGNDEAIKMLFTAMDVNKDSVVDLSDFKKYASNAESQIWNGFQRIDLDHDGKIGINEINRYLSDLDNQSICNNELNHELSNEKVNKFSRFFEWAFPKRKANIALRGQASHKKNTDNDRSKKTTDSDLYVTYDQWRDFLLLVPRKQGSRLHTAYSYFYLFNEDVDLSSEGDVTLINDFIRGFGFFIAGGISGVISRTCTAPFDRLKVFLIARTDLSSILLNSKTDLLAKNPNADINKISSPLAKAVKSLYRQGGIKAFYVGNGLNVIKVFPESSIKFGSFEVTKKIMTKLEGCRDTKDLSKFSTYIAGGLAGMAAQFSVYPIDTLKFRVQCAPLDTKLKGNNLLFQTAKDMFREGGGQIILQRCHSRYSGHISLCCIRFGDFFCLKKMVYCQTGKDPEPTTRSGHSKQPGCTSNGCIQWNCRSFCCLSNQSFKNKTTSPRNICTSLCV
The following text describes a protein:
Function:
Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MSVNIKIENAQKRYGDNIIIENLSLDIKQGEFFTLLGPSGCGKTTLLRMIAGFNSIEKGNFYFNEKRINDLDPAKRNIGMVFQNYAIFPHLTVEQNVEFGLKNRKVSKEEMKIEIDKFLKLMQIDEYKDRMPERLSGGQQQRVALARALVIKPDVLLMDEPLSNLDAKLRVEMRTAIKEIQNSIGITTVYVTHDQEEAMAVSDRIAVMKDGEIQHLGQPKDIYQRPANLFVATFIGKTNVLKGNLNGSILKVAGKYEVSLNNIKDKNIKGNVVISIRPEEFVIDENQTKDGMRAFIDSSVFLGLNTHYFAHLESGEKIEIVQESKIDSIIPKGAEVYLKVKQDKINVFTEDGSRNILEGVNNDAIGVAYVK
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MSAWQNFQKRAQIFGVIFALLHNLLLIFLITEKSHKELGTYKNLIILVAISECFYAVLEVTVRPVIHSFGFTFALIVNVEDSFLEYGVLKVLLAMYCAFFGSFLVIFSVQFIYRYWAVSGNKHLKEFEGLRIFLWTLPSIFCGLIWWLVAYFPCAKRPSTDEYLRDSVMKEFNLSIEENLYAAPYFYEVNTDGTTDIYYPSFISIILTTVLVNISVITVFYFGIKCYSSLREQGALVSQNTQKLQNQLFYSLVIQTVIPLFLMHFPVAAMYCFTFLEIDVGSLSGIVTVTLAIFPAIDPLPTLIMVKSYRTAIQFYIYLFFKTITKMLQPSQDNSIAMTQTRAI
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Note=Localizes at the cell tip and barrier septum.
Sequence:
MSEEDTSKLRILSVGSNAISAFISWRLSESKACHTTLIWRNRCESVLSEGIRIRSSVFGSTKWKPDVVAPTVEQLAMNSEPFDYIFVCLKILPSVYNLDTAIKEVVTPGHTCIVLNTTGIVGAEKELQHAFPNNPVLSFVLPDQFAQRGPLQFEHTTFAADSAKSVIYVGLTEEEDDVPDSVQDAMIETLTLTLEAGGVSCDFLSKIQKKQWETGVGHMCFYPLSIINDEPNLALMYRLKSFAKVIDGLMDEAFSIAQAQGCEFEPEKLDVLKRHIVNRMLATPRPSYPYQDYIAHRPLEVAVLLGYPVEIAKELGVSVPRMETLLALFDAKNKRNLTVRAGTPQSSPNFNPAMRRSPVGAASRSPSRSTIGISNRIGSVDDLLNTRQFTSSPIGGSMPKGPNSIYKIPSASMVNLSSPLVTSPSGLNPTGRPSRFGGRVRGNPLTMNKAGSVSDLLSTSTNMASSDALETASMIGVPSAMPPNSFDMLTLTQRRNRRNNQSSSPPAPSDRRYTMGARRPVQTRGMTDSVIPILEDPMSTLYDTSRYPTRNSKPATPKASRPPSIASTVHRRMD
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDWGTVSTEDLIEALKEVEWSSPPRPLNEFFSKFTLPRSSTKWNSRLKCNLYYYRTNYFLMVMFILGLGFLRRPLAIVAAMSTALTIAFLNDSFAGTFSEKVTRTVRRFSPHLAAKMRPPLMPVLRGRPSSKRAIYICGRPRWQFVLMFSAVSFILWFVSCGLLTLLWALAIGLLATIMHASFRTPNLKARLNTFREEFRAVWRNYSDI
The following text describes a protein:
Function:
May play a role in regulation of a variety of G-protein coupled receptors.
Sequence:
MTGAEIEPSAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQATTGARPKTETKSVPAARPKTEAQAMSGARPKTEVQVMGGARPKTEAQGITGARPKTDARAVGGARSKTDAKAIPGARPKDEAQAWAQSEFGTEAVSQAEGVSQTNAVAWPLATAESGSVTKSKGLSMDRELVNVDAETFPGTQGQKGIQPWFGPGEETNMGSWCYSRPRAREEASNESGFWSADETSTASSFWTGEETSVRSWPREESNTRSRHRAKHQTNPRSRPRSKQEAYVDSWSGSEDEASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNREDCFESESEDEFYKQSWVLPGEEANSRFRHRDKEDPNTALKLRAQKDVDSDRVKQEPRFEEEVIIGSWFWAEKEASLEGGASAICESEPGTEEGAIGGSAYWAEEKSSLGAVAREEAKPESEEEAIFGSWFWDRDEACFDLNPCPVYKVSDRFRDAAEELNASSRPQTWDEVTVEFKPGLFHGVGFRSTSPFGIPEEASEMLEAKPKNLELSPEGEEQESLLQPDQPSPEFTFQYDPSYRSVREIREHLRARESAESESWSCSCIQCELKIGSEEFEEFLLLMDKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNLNMIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKFHVLKMLLNLSENPAVAKKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKMSLIDDDFSLEPLISAFREFEELAKQLQAQIDNQNDPEVGQQS