lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.
Subcellular Localization:
Cytoplasm.
Sequence:
VAMNGRARKEAIQATARELIKFVNRSPSPFHVVAECRSRLLQAGFRELKETEGWDILPENKYFLTRNSSTIIAFAVGGQYVPGNGFSLIGAHTDSPCLRVKRKSRRSQVGYHQVGVETYGGGIWSTWFDRDLTLAGRVIIKCPTSGRLEQRFVHIERPILRIPHLAIHLQRNVNENFGPNTEMHLVPILATAVQEELEKGTPEPGPLSATDERHHSVLMSLLCTHLGLSPDNIMEMELCLADTQPAALIDSCASPASLAREPHVRMVTLYDNEEVGSESAQGAQSLLTELILRRISASPQRLTAFEEAIPKSFMISADMAHAVHPNYSDKHEENHRPLFHKGPVIKVNSKQRYASNAVSESLIREVAGQVGVPLQDLMVRNDSPCGTTIGPILASRLGLRVLDLGSPQLAMHSIRETACTTGVLQTLTLFKGFFELFPSVSRNLLVD
The following text describes a protein:
Function:
Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein.
Sequence:
MPSPLPVSFLLFLTLVGGRPQKSLLVEVEEGGNVVLPCLPDSSPVSSEKLAWYRGNQSTPFLELSPGSPGLGLHVGSLGILLVIVNVSDHMGGFYLCQKRPPFKDIWQPAWTVNVEDSGEMFRWNASDVRDLDCDLRNRSSGSHRSTSGSQLYVWAKDHPKVWGTKPVCAPRGSSLNQSLINQDLTVAPGSTLWLSCGVPPVPVAKGSISWTHVHPRRPNVSLLSLSLGGEHPVREMWVWGSLLLLPQATALDEGTYYCLRGNLTIERHVKVIARSAVWLWLLRTGGWIVPVVTLVYVIFCMVSLVAFLYCQRAFILRRKRKRMTDPARRFFKVTPPSGNGTQNQYGNVLSLPTSTSGQAHAQRWAAGLGSVPGSYGNPRIQVQDTGAQSHETGLEEEGEAYEEPDSEEGSEFYENDSNLGQDQVSQDGSGYENPEDEPMGPEEEDSFSNAESYENADEELAQPVGRMMDFLSPHGSAWDPSREASSLGSQSYEDMRGILYAAPQLHSIQSGPSHEEDADSYENMDKSDDLEPAWEGEGHMGTWGTT
The following text describes a protein:
Function:
Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source. May also use glycerophosphoinositol as substrate in vivo.
Miscellaneous:
MISCELLANEOUS: Present with 2300 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MKFGKTFANHRIPEWSSQYVGYKSLKKMIKEITRLQEDIYRAHNKNSYDEGRPPTKMRDSSNSAQNYLDSPKIQKLLASFFFAVDRDIEKVDTFYNSQYAEYKKRFERLLSSNQFNEIKSTLVVDANKEDAVAQTLLTKDTREMNMLLKGTSQASRLSYHKDDLIEIQSILAELRKQFRNLKWYAELNKRAFGKILKKLDKKVGTNQQMSTMKTRILPLQFANDSLITKDLSLLKTIWEQVTFRINSYERVMRSTSPNANANDNTEFFKIICVFIEEDDSKGLIRELTNLYSELSLIPTRIMISVLNKAALSKSLACIDAILKVIPSLNDSEDINRRNFFHHHIIAIGKLIRKQEILSRKKKSQPSKYTNSEGEIVTDLRTLHTTLSAPAESDSITEEEKSSACTLSYILEELPIHLRPCLFQHDNYKRTPLHYSCQYGLSEVTKLIIKLMKEWNIWNEIPIDDVSAFGDAESLTPLHLCVLGAHPKTTEVLLQSLDPNVKLKSSSLLHLATEWNNYPLLHVLLSSKRFDINYQDNELHETPLYLACRLNFFEAAVCLLYNGADLEIREKLFGWTAIFVAAAEGFTDIVKLLIANNANFDIEDEGGWTPMEHAVLRGHLHIADMVQIRDELVTHPHSQLNSGSEEKEPLNEISAGELNERNENGNGGNKGSLGKLAGPIKSYGHRFLDNNESLILITLGSNDTRNKSPSISLSSEALAKVIGLETDCALSLVISCNDSIDKSSVILDLPLDDNVDAVDFKVPFKVDYSHTLYFDIVPTYGTRSLETHNRIDCQKNNNNYVMARGVSMLNKSYSSVGVNRSILNGSVTVPIIANHTLEILGTLKFEYIIITPFEHPQLPLERTETYWKSLVSTRVIGHRGLGKNNPNKSLQIGENTVESFIMAASLGASYVEFDVQLTKDNVPVVYHDFLVAETGVDIPMHELTLEQFLDLNNADKEHIQRGAGHSPHHVNGADTALQKYRGRSVDDSDVSTLRRAWDLHDNDPNGKSNNAHWSDNRMRLTKTFKKNNFKGNARGHSIASSFVTLKELFKKIPANVGFNIECKFPMLDEAEEEELGQIMMEMNHWVDTVLKVVFDNANGRDIIFSSFHPDICIMLSLKQPVIPILFLTEGGSEQMADLRASSLQNGIRFAKKWNLLGIVSAAAPILKAPRLVQVVKSNGLVCVTYGVDNNDPENASIQIEAGVDAVIVDSVLAIRRGLTKKNEK
The following text describes a protein:
Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Sequence:
MKPTAPGRRSTPSAISRALSKSRTLSRESPPSPTLPTDGPALGAFCAPGSVFIMDERVQLTTGLQTQDRHLFLFNDTLVVAKSKSSSSLKVKKQVGLSEVWTATCLGEVSEKRASADHSFVLGWPTANCVVTFSSSETKERWLSALLWQSKELKEKEEPQSLPLQILMLEPDRRISTTTVTVSNTETATGVIKMATRQLDFPGRVDDLHLWVISGKEDVAYPLIGHEHPFSIALSSLRDAAERLPGADGSATHPSTDCPLDQLARGPPCRFILKPRTQGPPQLQRAEPLQKLLRRKKSLMGWALRKSLPSPSASPATGSPTTPHKLFGLSLSSICLNGALPKPILDLLLLLYQRGPSTQGIFRRSANAKSCKELKEKLNSGVHIPLGAESVLLAAALVTDFLRNIPDSVLSSDMHGLWMEAVDTENRGSKIKAIKSLVDQLPEANRLLLRLLFTVLRRIEANAGQNQMNALNLALCIAPNMLWPPSPACPQEESKSAGKVALLVQLLIENAVEIFGDDGTSLFQRAAEERSASLDHLLAPGRWDSEEEREQTADRGELGTQGSPPEGEHQDWGPFGKTTASYGQERRREARPPAGGERAAGGWLRPAWDRCASEPSVRSGSRPPTATREPVARQSSCDDALLRSPGDPVQRLKLLQLESQKLLGLGLGPARQRPPPPGPQGKPPLPQTPPPPTSLSSLSSLSSSSSSSSATTPSPTGSSPSSLDSAFSCCSEPSGAGPPDHLTLPFMFGTSARLRAFSPQAARRTRPDQRESPAPPQARPPEGPDPRSRDAGGRDDEEGAAAAPEPQLHGNWEGGERVGRAPWARSPLARPESPRPPSPGAPEGGGGPLREAPAQRPGKHTRTKITFYLAPGGSEAEGGGPGARPSTLRVPIPQTVFYGQNTPLVLQSGARSQRPPPGSPGPSGVPPSPDGEPPASVRHTIRIVLPASVRGTVRGYFRSAGPRSCWEDDAARAVEGELLRGRAEWQEGAQGAGGHPKEEPAPGPCPESFV
The following text describes a protein:
Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MSHLLFAYYLCNDIRSFQNLLKQDDSKVKEPRKGFSEKSGQKLRINQKDRYGRTVLHIAVSENKNSFVRSLLQHKGIDVFVQDEESGYTALHRAIYVGNLEAASLLLSKDPSFRSLRIKDKEGLSPFQFLSRVLSSTIHPVLDLPIIGNELYGFGTNVNNTLGIANGKEPSSPERVFLLKNQTESPTSGQLFSRDKILDVQASKFHSVVLTDEPSQNVYVCGIGAGGRIGFNTDVQYNFIPIPGIIHKVIQISVSHTHSLALTKFGSIYSWGKNGSGELGLSNDELKKDDPIQITPRRISAFKDYQIIGMAAGKSYSVAWTDTDIYSWGLNNGQLGISDHISVVSTPRRVAGLLSPVIHAVCTTRATICLLQNNSIIAFCNYNQVKLPFNVDFGSSLKVTKHPLSLTRFNVRKLLASENKLAVLTELGEVYEFDMKLLLDRDSTSSKNSTRTSFKFTPLWIFESSDLAALDIAWTADNSLILCTRNGTCWKRELRSKKREKSSSSPYSRGPYKYNRIENLQMVVGVRASASGSFFAIRNDYLPPPIYKPSNMLIDLLRSLLPYDHLLHVRQPRLIPPEDEDGVPIFDEDRAASSNEMQLLFEGSIPILTSYENYKQSFSDVTIYCGTSMFHSHKFILCARSSFLRKLLLQKKKSSVSNIIYIEEITQSHSTIRVEDIPPLAVAILLHYLYTDTLLSPWHLDSRFSPLKENLSKLANLLELPHLAEVLPFSVSRQPLLSLTNDILQLYNNFYVLCEETMDTVIKLKDGELKAHGLFLSLRSEYFSSYFQFVSMESNSFDIPITVNLSHLTVEHMSIVLRHVYSDLKVELFDDLKESDFHNWLETMFEILSIADELLFLELKSIAQQSLLRFLNLKTLPTLMDLSLSYHAEELYSRCIDYACHNIEFFLEANRISEWDGFHLKKVAQRLTELLSDQRVHLPSSKIANRLLIRDPVLMEKRNYELKVLREYLFSQESSQLWDDSPYRSIFEDRRCSTSAVILESGIVPSSNQSDSLNKEDAEEKSPKPNVVNVTSITKTAGASVEIQNNIESASSGGDKTQLNGPGADQPVTATITFDKTSPWRNRENLSHNNNTTRASLRELLEQEKADASTTTVLSDSRFMKAPTKKSQREKKKELSKQVPISKTNVGHIDIELGKSNHSNPWSVATHQRGSFSSSTGVKKSFNGILREAAREEGSSQVIYQESKKRISNGSPTSWNLLTKPSPRSASLPKNSQPLSISEIMTEQKEEIESQKRRSSFRKTIEEIQQEEEFQKWWEEESLRVQKELGILKTERDTSTNRKQGQASKQPQRRHRKEKDSKVSESTAEFKSLPIDIPRTTHKKGKARAVK
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC21.
Sequence:
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWRDGHPENTA
The following text describes a protein:
Function:
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MEFKHISVLLEETIDSLNIKEDGVYVDCTLGGGGHSKEILKKLSHKGKLIGIDQDTSAIKAAKERLKDYENVIYVHNNFYNIDSILEELDIDKVDGIIMDLGVSSYQLDEASRGFSYMKDAPLDMRMNREENLSAYGVINNYEEEELFKILKNYGEEKFSRKIARFIVEKRTENPIETTGELVEIIRKAIPAKFQREGHPAKRTFQAIRIEVNKELQILNKAIEDSVNRLNKDGRLSIITFHSLEDRIVKVKFKELEKPCTCPPSFPICVCGKEPQIKIITKKPIEPSKEEKEINSRSRSAKLRVCRKI
The following text describes a protein:
Function:
Involved in cell division. Involved in mitosis. Regulates dynamics of microtubules (MTs) during mitosis. Required for cytokinesis. Binds polymerized MTs in vitro. Is able to rescue a mitotic division defect, the proper positioning of the nucleus, of the S.cerevisiae BIM1 knockout mutant in a complementation assay. May play a role in spindle positioning and MT distribution. May be involved in MT nucleation for the formation of median bodies and in the biogenesis of flagella. Based on its localization to both the flagellar exit point and the distal flagellar tips, it may mediate the transition from anterograde to retrograde intraflagellar transport (IFT).
Subcellular Localization:
Nucleus membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Nucleus envelope. Cytoplasm, cytoskeleton, flagellum axoneme. Cell projection, cilium, flagellum. Cytoplasm. Note=Localizes to the plus ends of mitotic and interphase microtubules. Localizes to the eight flagellar tips, the median body and the mitotic spindles. Localizes particularly at the distal tips of axonemes and axonemal exit points (flagellar pores). Localizes to nuclear membranes and median bodies in trophozoites. Localizes to axonemes between the two nuclei in trophozoites. Localizes to the mitotic spindles of the dividing trophozoites at anaphase. Localizes mainly to the nuclear membranes 24 hours after induction of encystation and to median bodies in some of the encysting cells. Dispersed in a condensed pattern in the cytoplasm of the cysts, but absent from the nuclear membranes, 48 hours after induction of encystation. Colocalizes with aurora kinase at the nuclear membrane and the median bodies in interphase, at the spindle microtubules surrounding the chromosomes in metaphase, at the mitotic spindles in anaphase and telophase, and at the nuclear membranes in cytokinesis. Does not localize to the median body during cell division. Does not localize to ventral disk.
Domain:
Interaction between the C-terminal EB1-specific domains of two protein monomers is sufficient for homodimerization.
Sequence:
MPPVKAPGNVSDCYFVGRVSLLKWISELLNEPVKKVEDLASGHHYCMALNLVYPGQVNMHRVRMNAINEWERSENFKIIQDVLSRNNIDKGIDVNKLVTGKYMDNFEFFQWFKWFFDQNYKGSKSGATESGSANAVTKTSKPGNRSGSTAASMQNPKASSTSGPSIDSKELEDLRRQIAKGQLESQFYFDKLHEIEIYMDQMNELMTQVEIAEPEDSPFYIKSVVKKIEDILYAEYHQ
The following text describes a protein:
Function:
May function as an adapter protein.
Sequence:
MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYREQKDLDFEDPYEDADSRLEPDSAGPGDSKGPGDAKYDSPKHRLIKVEAVDMARAKVLLGSACEESEVDAEYSDPFDAQPHPPPPDNGYMEPYDAQRIVSELPCRGVQLYDTPYEEQDQEPGDETPSGRKPRQSRLPQEDERPADEYDQPWEWKKDHISKAFAVQFDSPEWERTSGSAKELRRPPHRSPQPAERVDPALPLEKQPWFHGPLSRADAENLLSLCKEGSYLVRLSETSPQDCSLSLRSSQGFLHLKFARTRENQFVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVSQSP
The following text describes a protein:
Function:
Hydrolase that deubiquitinates polyubiquitinated target proteins. Required for preventing the activation of the Toll signaling cascades under unchallenged conditions. Essential for bodily calcium homeostasis; [Isoform A]: Required for preventing the activation of the immune deficiency (Imd) signaling cascade under unchallenged conditions. Regulates the Imd pathway by specifically removing 'Lys-48'-linked ubiquitin from imd. Also promotes imd degradation probably by binding to imd and enhancing its association with the proteasome.
Sequence:
MMLDIKKTRGFHKIPQASKLQSTTKTSSVVATSASSQNEVPSPGGSAGSKVGATNPVRAANQRFFLVSSYKDPTFLKAECDLAHAHVTTSKVKTTLQPHRRSRAGEDSRNNNYNTSRAPTLINMRRPSLFNGNQQPTTTNSTTINNTTSRNTTSNTSNGVLKYSVRSTTATATSTSTRNYGKLKPLNNNQTTAGVAMMNGHTNNNNNNTRNSSNINNGGNNNMQRQQQQHDDISFIDSDDPPATGGPEAGISTTKTSICYFKPITPPLQLRHEQNQVQQQEEQPQPSSSKSASHRYPRPKSTIIASAHSNFAASFEKFSGGLYRQTNGETNIESKTSSNARRYGIDSLSIKASIEKFNNLSGQKRQNPGSGSGIGPGSATASGLGGGRLSVASRSNHGSQAGGSSSNLQQRYSSDLDNIRVAAGYSSSLTRAAYRTTATMNSVSTPVAVTSELGGPISGDGGETATAMGQPTSKVTVRGAHSNRQPIECDSVVLTNKASKDATTAATPTVATATATHTPATSSVSTVTVTAAAPNSASDSTLARSGTGSSSTARSVLPPMTPTSSRYWDRDSGTSRSSIGTSSALNSSSLKHNSDDGYKTASSSRDEKSEGLCGLRNIGNTCFMNSVIQCLSHTQELTRFLRSHHGSRSLSTKDQQILHEFAKLIQEMWTANVHTVTPMELKRAFSTKHRMYSDYNQQDAQEFLRFFLDSLHSALNSGVKGETLNIDDNLSDNKKADLTWEWYTRHENSLVRDLFVGQLKSTLKCTTCGNTSVTFDPFWDLSVPLPSSSRCKLEACLDLFIREEVLDGDEMPTCAKCKTRRKCTKSFTIQRFPKYLVIHLKRFSETRWSKLSNIVEFPTSDSELNMGSYGANSNSNVHYSLYAISNHMGSTAGGHYVALCKHPVSRKWHEFNDNIVSDALSENHLVSSSAYILFYERT
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSSPTVYQPLVYWAQTEKTISLKVDLNDVSSPEVELKSKTLTFKGYGLGASGIHQYEFSLDFHDEVDPDASAFRVLDRQVDFNISKKSVLSFWPRLTSGERPRWLRIDFDRWRSGESDEEEDEDAKKKREQEEHFKELEEQLMGAEKQAYQDIKNVYLFMYNLIQWIIFTMVFVYCLGKFILHGKEDLPAAYDWAIIPLGIAQVFACLEVIHAMTGLVKSGTMTVFMQVFGRNFVLFVVIMNNPELKEEGMTLYLFMVWSAVEVVRYPFYMLSCIDYESEVVTWLRYTVWIPLYPLGFLSEIMVVCLAIPFYKETDMFSVHLPNRANIAFSFVYYMYLHIIIIVSSAPTLLSHMWRLRKKKYGKRRIRIGGVKPKMN
The following text describes a protein:
Function:
Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
Subcellular Localization:
Cytoplasm.
Sequence:
MILMSAFTSLRRVSILSRHFVGVQQTSNRLRALSRMALNEDGKPTAGIIIIGDEILKGQTLDTNSHFICTELYKLGVRVERVSVIHDDLSVIAEEVASFSKRYTHVITSGGIGPTHDDVTFEGVAKAFGEEIVPHPELVKLCKDYFGANSSLDSPQLKMALVPKSSTLTFGTNLKTGQKMLYPIISVKNVYIFPGIPKLLEGAFLSLKEKLFQGSPVHFHLREIYVGTHEIAIAPYLNQFNAKYNGKVHLGSYPKLSHSYYTVKVTLECEDEETLNKAHSELLSLLPQEHIVNYELDPIGKAPEAVYSLASLTDQTSPGTTQLESSASSPATCIASDSATGSEDLLSARVAVAVKVIEEALEKYKMDEICAGFNGGKDCTALIHLFHAVVKRKYPDYKGQLQVLYIQHPHGTFKEVDEFVDESVKRYNLKTILIQGRIKDALWELKKSNPSIKAVLMGTRQTDPHSASLSNFSPTDEGWPELMRVNPMLFWSYHDVWVFLRRLFVPYCRLYDKGYTSLGSVSTTSANPALMYTTERGEIKHHPAHKLVEEEQERSGRKPFSPK
The following text describes a protein:
Function:
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MADMNILDLFLQASLFVKLIMLVLMGFSIASWAIIIQRTRILNAATRDAEAFEDKFWSGIELSRLYQESQARRDTLSGSEQIFHSGFKEFARLHRANSHAPEAVIDGASRAMRISMNRELEALETHIPFLGTVGSISPYIGLFGTVWGIMHAFISLGAVKQATLQMVAPGIAEALIATAIGLFAAIPAVMAYNRLNQHVNKLEQNYDNFMEEFIAILHRQAFASTESK
The following text describes a protein:
Function:
SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination.
Sequence:
MEDWLHCNACFVRIIHGPVSFSVTNCAHIFCNKCIERVANSTCTVCNKKCSAYTLLHNKMDPTTANYFKDPGELAQKAMNMFKLSEDVRKFQATQRKSLFKAIVNKAEQKEKLLQTAVATMSETKRKNSELKFIIKNKNNLSSVSPKSHSYMAMQYSPDCSPPSSPNRNISTRKTPPHYYSSVPCTPNKTSVDGHQHRTLLSGGYTVSPNKEKPRMSLRSPPVGGKIQTPPDLRLHHSSPDGIVSKQASLHSMKQSTYFSKFQTPKSPMHGTTPHSTHSTPQSRCGTPRVKAITNYGVSLIEKRRLVGHQ
The following text describes a protein:
Function:
Oxidizes hypoxanthine and xanthine to uric acid.
Sequence:
MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPHAEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVAAETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEGFQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFDIPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHPMKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGISVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEHRIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRLSLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTASRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKELAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAAGPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLIAIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKGLKQWT
The following text describes a protein:
Function:
Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity (By similarity).
Sequence:
MSAFEDLGVLPEIIKAIEELDWLLPTPIQTEAIPLILGGGDVLAAAETGSGKTGAFALPILQITYETLNKKAEIPIIAPTNTSGEDGTSGGGGGGGGGDTIELDQIDRDKNMAVDGLICQSRSSDWCGIKATKGISSGKFYYESIVRDEGLCRIGFALKKSSRNIGTDKFSWGYGGTGKKSHESKFIDYGKPFGNNDVIGCYINFDEEIIGFTKNGQDFGEAFTFNSKAGIFYPALVLKNAEMEFNFGSKPMKHDLKGYKPINQAELLIDQQTSTQIDNSKNNNNNNNKKGSGNNKKNKGKDDDKMNDEDNNNKQPRKTLSLIIEPTRELADQAYSAILNFSKYLDSPKIQVSLCIGGEKSNGGRNKIEGDIIIGTPGRLESLVKEGSIDLSSIKFFVLDEADQLIDDNLAIVNFIYNKLPIGQNLQVLFFSATLHSTKVIKFCEQITKNPTWVDLKGRDFIPDLITHAYVKADPIKFESLWRNSENPLRIRTDGVHASDVQQFGKLKEPEQKSEAIKLLKAQLLLKCIQSFKMDQAIIFARTRLDCDHIHQFLKDAGGGNTSGLEGEFSSTVLHGGDNISRARKDNLEKFRNGDVRFLICTDVAARGIDIRGLPYMINYTLPESFEDYIHRVGRVGRSDRIGLAISLVAYEQEKVWYHTCRDKGKGCHNTKLTENGGCCIWYDEPQLFTAIQENIGPIELDSDFQLPKDMKQLNFGGSTKLTGASADYKPHTEELRSRVLQLSQLEETIQIDYLTLPKRIIKLK
The following text describes a protein:
Function:
Involved in the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons which is essential for germline integrity. Likely to act by recruiting Piwi proteins such as AGO3 and piwi to the piRNA biogenesis machinery in the nuage. Required for the final steps of primary piRNA biogenesis by participating in the 3' end-trimming of piwi-bound intermediates into mature piRNAs.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Note=Component of the perinuclear meiotic nuage (also known as germline granule or P granule), a germline-specific membraneless ribonucleoprotein biocondensate involved in post-transcriptional regulation of transposons and mRNAs. Expressed in the cytoplasm of germline stem cells, cyst cells, nurse cells and oocytes, with strong accumulation in region IIb germline cysts in the germarium. In post-germarium egg chambers accumulates in the perinuclear loci that appear to be the nuage.
Domain:
The Tudor domain is sufficient for binding to the N-terminus (1-14) of both unmethylated piwi or piwi symmetrically dimethylated at 'Arg-10'. However, it may not be sufficient for binding to symmetrically dimethylated AGO3, instead this interaction may require a larger region of the C-terminus which includes the Tudor domain (257-576).
Sequence:
MLRNTPFGATPTYKLLLGFGLCSLGGAMLYAYFKTRNDEEEADSGGQRPASGIRGQTEEQKPQKEVCLKIVVDNEHVPLIMGRGGSNIKLIEEKTLAKIRLRDKDSGHKFCDISGVPDAVKAARALLIKEIERAPVVKVELQVPQRLASKINGRGGELLQEIRSSSLAKLNIDLNGRNGKAKITIIGNQKQVNIARKMLDDQIEEDEELVRSMEEVEQRREPRRSPTNSIASSMYSSQTSLSSHTQPRDKLMASKGEGKPMEVYVSAVASPTKFWVQLIGPQSKKLDSMVQEMTSYYSSAENRAKHVLTAPYVGQIVAAVFKFDEKWYRAEIVDIMPNQYNPKEQVIDLYFVDYGDSEYISPADICELRTDFLTLRFQAVECFLANVKSTIQTEPITWPKSSIAKFEELTEVAHWRKLIARVVTYKERPRATTAVSAAAKEGTPLPGVELFDPADNSELNIADLMITQGFALPLDDSYPVRSRSSTPSSNSDSTIEELCVSNPVTPLTPHSPMSMSIDVDSITQAENEHLAQQLQHLQHKLNGNDIKNINPAKLTATDLENGNNNNASTTNGASAH
The following text describes a protein:
Function:
Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
Sequence:
MNGPLEQLSGELALRPLIISILDWAAVGLLLYLAFQLIRQTRTVWLIRGFLILSGAFFLSNLLGLTTLNFILDKILIGVAVAVPVIFQPELRRFLEQLGRGEIFTLLKPDRVPDFEKEALDELLDAVQDLSEERIGALIVIEQSPIDDRLLQDPGDTMDAVLSKSLLLTIFYPKTRLHDGAVLVRDWRIQSASVILPMSTQIPARQLGTRHRAAMGITEQTDALCIVVSEETGSISLAERGKLQRPLTVEQLAEALNRRYRRDQPPSVFTIPALSDWTRKLFPASSSQSGNSD
The following text describes a protein:
Function:
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MDEVVKGLIKNEHVLVVATICTETVEYARKIHDTWPTATAAMGRVIAGSVLLASTLKDRQKIMVQIKGDGPLNEVVAEADSFYRVRAYVKRPHIYMGLKNEKIDVGRGVGKGFLNVIRDLGLREYYQSSVELQTGEIARDLAYYLNVSEQIPSAVSLGVYVEPDNSVKAAGGFMIQTMPETRTEIVEFLERKLSETQSTSSMILQGMDSLQILEEVVGLPIEVLHRGTVTYFCPCTKDRVINAIVTLGREEIQKMIEEGKTVDVECYFCKKKYEVTVEELKILLREI
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
Sequence:
MTDPTTSIVTKPEGKPTPTPTKQEPAHSSAKRVRGPTGVYSKLLPISLLPNNKPESFLTRLLPLLRPDHHLSNSLGSSPAITANYEKITNSVWLTSGRTILWQQGFFGKGSLSRSEPTWLQRAKNRMLLEVLEDDRYLKLTAEELTAKRRVERKESKIQKSKLKQLAMNTESVVATSSETVETPRETKPAPKQKLAQLIPDDLMLEVEKIDDLEHLQLMNEEAFFLSFGLGCLDVSLSAEDSSSGPLTILEMWDLFCRASLRGQSDQTIRPDNPFILSYVVYHHFRSLGWVVRSGIKFCADWVLYGSRGPVGGHAEFAVCMIPVYADGRPVETMEDRSSWRWLGTVNRVCSGVKKTLILVHVVVPDEFETDDLDSPEILTKYIIKEIALKRFIPARMRD
The following text describes a protein:
Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus, cis-Golgi network.
Sequence:
MTVFNLYIFDRNGTCLHYSEWNRKKQPGMSREEEFKLMYGMLFSIKSFISRLSPTDYKDGFLNYQTNKYKLHFYETPSGLKFVMNTDLAAGNMRETLHQIYSSIYVEYVVKNPLYELGQPIESELFKAKLDNFVRGLPMFATKSS