lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Sequence:
MDTDKSDLSLETMQLLQERTPPQNPGMDGSVLRTSRRIKEKQNQRKKQILPPKCLTFRSEVKSTRRAVKRRISGSEKEKEVKRSKADPDHESLPQGYREGLSEYQLERLENIRKNQAFLNSLNLTEISEALRPKQKPTQKGLKKEKTQVEMLPVRKSLRLQNKGPQSTTATEFTFPTTYELEKEAKPPGPIPLDPINLDEDATLPDDLLDVWNEVPLEQSTGTPDLKSYERMLKKLSIDDSRVVKVVKERICCAAFHPSSNLLMAAGDKYGHLGLWRPDAEWGDDGVVCFEPHSRAITALAFTSQPCNLITASYDGSARSMDLEKAVFDEVYRSSSSLKSFDFLSSDCSTLLFGEWNGDVAIVDRRTGNSCESLHAMTAAPLRGVHVHPVQQHYFLVAESSFVNIYDLRHLKKRNSPAVCELYGHSRSTSSAFFSPLTGSRVLTTCMDDCIRVFDSSQIAGSIPALTSIRHNMQTGRWLSRLCAVWDPKHQECFVIGTMDRPRKIKVYHESGRLLHTLQNTEHLTTVCSVTAFHPSRNALLGGNASGRLHIYTD
The following text describes a protein:
Function:
Phosphorylates PPP1C, phosphorylase b and CFTR.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKGLGLTLEGFGLLLILTLGRVQAAPLPETGAEDVPTDGVPLFSVLLSVCSFIALVLLVIGCISCCKEQEIDFKEFEDHFDEELDFTPPAEDTPSNQSPADVFTLTVPTVSLSVPSQLQAAQDLSKYQIPRHSLSYIQEIGNGWFGKVLLGEIYRENSVARVIVKELKASANPKEQDHFINHGEPYSFLHHPNIVQCVGHCIETMPYLLVFELCDLGDLKTYLTNQREKLKGDTEIVLLQRMACQIAAGLAIMHKHNFVHSDLALRNCYVTSDLTVKIGDYGIGFTRYKEDYMETTEEKFIPVRWTAPELVTSYQDQLLVADQTKSSNIWSLGVTLWELFENAATPYEDLSDSEVLAQVIKQREVKLPNPQLEQPYADRWYEVLQFCWLTSDKRLTAEEVHRLLTYLRMQSQKETEDDFEQRWNSLKPNTSNRQASTNNLAFPILEHFSGDELSQEMDEVLTVTETSQGLSFEYVWEAAKEDHFEEQGHSDSDATVNYNSLFFPVPVDVLQKPGVDAEQGKPEHSGRDNTLGASEVVPVFDSHNVSVANEYYIQLEEPGESRLDFDNKKQESESATLQFIALNELKSSGTNIKSDFLPFEAEHRHLPEYLHVSSDSFPFYNSIKNVDWSDKKPLGSTVRELPLQNGLHADNPSLPFSESFKYSEKESTIWGNILETDPVVLNVEELSENFLFLRENHLLSDSLFKGNKTYEPQAEFSSKVSSQKLFEISHTNSLDVELQLSELNSSVLQSNKTSFDNSPQTGQESGLKTELTLPLPNTEGLTNDFFVTSVRPGLTDNQHTAIEVKNVNHASEGVPNSQLAPKSHAAIDDSIDLYRSGSNENIFVLPSTKVVNDDAPLGQACLNSVEAPSPQHHTDSASVNDDDLNPFIVTSAVPSDSTSQDSLLDDSSNFMPSLVPSIGTPDSLDSLDVQNVLETLESEEHQKFGHSDKPADSGYETENVESPEWTSHANGQLGHDPNERNGVSAATAPIIIISDADHLLDDVGKTQMPTDVSPSSYRDSAYFSDNDSEPEKRPETNSNLPVLLTFSVTGSLSESTDKVISPELAAKNETEVEIVSQKDDPSFPLQSVEQVETDLNKHEDSEENEHYEEWNDFSPSSEDDANHFSAEPTRPENDEDFLNPFGASEIFSSMNKLKEMPIVSLPDAQKLKEPDMEGKYLGKLDASGLLDLSSEDGMDADEEDENSDDSDDDIRAFNLNSFSSDSDDDIVHPVPVVHVENDDGRHLKSLIKSSKPATDMFSELEKRSSKAVSFFDDVTVYLFDQETPTKDLGSQVVDTNSQIFSSCPTTPPPPPPSYLNRFTNSESSTDEEGGGFEWDDDFSNTEPSFLTKPATGFSGQKLSMNPSKYFSPPPPRSSDQNWTHTPSYSRFSISPANIASFSLTHLTDSDIEQGGSSEDGERD
The following text describes a protein:
Function:
Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes at the transition zone (TZ), a region between the basal body and the ciliary axoneme in the olfactory, auditory and speromatocyte system. In spermatocytes, localizes in the transition zone and the migrating base of the spermatid ciliary cap. Co-localizes with the tectonic-like complex.
Sequence:
MQKSRDIKRTGVYRVSGNIGDLQLELKLRHISEWLPVPKFEYAGAQSTNAYGDHYPGSEEDIWQDCYIHVPQGDDSCGGKTGLGYNCSYYNVGIGYTGRRRRSPISQHEGEMEKDKNEGEITDLESQSNRSWSILSDNSRPPAGDLFYKRNKELCNGAIATIRISWQQKHFSQAELEQYINNPGSCASKLQRRYHRWALETLKLQQRYLRKLENLEDAETVEDPEPITIRRRIRKPKAKQRGCSAAAHPTITSLSSANMSEVSILDDPNFAARTCLIHTLLDNDSESLMPAEASEFHKKGYQLMYIYADLQQDTLLVSIRYDPEQGLLYVYPDFSSSAQDLDYVIQIERNNDCRQLYAFGFENVTPLEAYDDDGFSEEADGEDEQELGDGLPIEEDLPEEASAEEILEFYRRRREAASERRSLLQFEMPPKRMKRVSLLLELQEGQNFENPNIHVRYYLKAPANTFYEGTPGVDTMQGATATCRNAGDWRSAHLGHCWQVTLLLEEQHHPADLLHLYFEVISIDSWQRERCEGYAHYAIPLTSALPTDSIRLQCIRPLGNWLDALNRYFIGGRQLFDFESFFDVHRQSEMHSRLNFNSDRPMTTTGTLSLRLQKLQQRQIDTSDQFHHHFHLELGNDSSDDGDSNDDDVRSSSNPDTSRATTLDEVMAAFVEARKRIELLLGNSSETASPSSAYYQAEF
The following text describes a protein:
Function:
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
Sequence:
MIENWPKKPEGSQWTDDQWKAVVANGRDILVAAAAGSGKTAVLVERIIKKIINEENPVDVDRLLVVTFTNAAAQEMKNRIGEALEKVLIDEPGSQHVRKQLSLLNKASISTIHSFCLQVIRGYYYMLDVDPRFRIANQTENELLKEEVLDDILEEEYGIEDNTIFFELVDRYTSDRSDDDLQRMILALHTESRAHPNPEKWLDKLVEAYDVEGKTIEDLVYASYLLEDVKFQLETAEQHIRKATELAMLPDGPAPRIETLQADVALLGTLSSAARESWTSVYEAMQNVSWQTLKRIKKSDYNEDVVKQVDSLRNKAKDEVKKLQEELFSRKPESFLRDFQDMHPVLEKLVQLVKVFTERFQAMKRDKGMVDFTDLEHFCLQILSEQSENGEMNPSAVALQYRNKFAEVLVDEYQDTNFVQESIIKFVTKDSESEGNLFMVGDVKQSIYRFRLAEPGLFLGKYKRFTQEGLGGGMKIDLAKNFRSRHEVLAGTNFIFKQIMGEEVGEIDYDADAELKLGATYPEGEDVAAELLCIQQTEEEVIDGEEGAEVEKAQLEARLMAQRIKAMVDSGYEVYDRKNDSMRPVQYRDFVILLRSMPWAPQIMEELKLQGIPVYADLATGYFEATEVNIMMNVFRVIDNPMQDIPLAAVLRSPIVGLSDEELATLRAHGKKGSFYEVMSSFLKGAPLEEEQELHDKLEWFYNLLQGWREFARQQSLSDLIWKVYGETGYYDFVGGLPAGKQRQANLRVLYDRARQYEATSFRGLFRFLRFIERILERGDDMGTARALGEQEDVVRIMTIHKSKGLEFPVVFVAGLGRRFNTQDLMKRFLLHKDFGFGSQFIDPRKRIKYTTLSQLAIKRKMKMELIAEEMRVLYVALTRAKEKLILIGTVKDANKEMEKWLDAREHSEWLLPDHIRAGASCYLDWIAPSLYRHRDSEMLLELGQGSIPDEIYGYDTSWKVEVVDGNTLLAPEPVQEEKQELLEALREKKAVPLQSERKEEVYDRLMWKYGYEDATSHRAKQSVTEIKRNYQSEEGSDNAFIKKLRAPIKTRPRFMEKKGLTYAERGTAVHAVMQHVDLKKPITVEVLQEQIAGMVNKELLTFEQAEEIAIEKVISFFDSDLGKRVLAAKSVEREVPFTMMLAAEEAYQDWQGKSEETILVQGVIDCMIEEEDGITLIDFKTDTIEGKFPGGFEQAKPILEDRYKVQLSLYAKALEKSLQHPVKEKCLYFFDGNHVVNIEE
The following text describes a protein:
Function:
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSVRCLFIVSGVLLWTLVRLTMSIQLDYLFPETQDGDFGKTFKREMEEEMTFDSESTDHAYLRTRGGHGKSSASASPGIHDANLQNFHTKLPDDSSTMTAPTVSPDDKLAVSDDVVGATFMAAGRSFPSVLFSLVTVFFTDSRVSLGGVFASGVYRIVFVTGMCAGLSPTVLHLSWWPLFRDLSFYLLYLILVGLFFLDNAIRWWESGALVAGYILYVTFMKFNTQAEMVFKSILRKLKPVQTDNSAEASPKVSRNHPFRDFCAF
The following text describes a protein:
Function:
Required for chromosome segregation and cell division in early embryos. Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively. Within the tost-1 variant of the PETISCO complex binds to splice leader SL1 RNA fragments to possibly play a role in their processing. Promotes the biogenesis of 21U-RNAs.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Dispersedly distributes throughout the cytoplasm in early embryos. During early embryogenesis, localizes to the nucleus at prophase of cell division, and remains in the cytosol at interphase in 2- and 4-cell embryos. Localizes to puncta in the perinuclear region in the germline syncytium.
Sequence:
MSTSSHTVLLIQTSPRLDSRTWGDYESVTDALDALCKMFEDFLSKKSAAPVTYDVSQVYEFLDKLSDVSMMIFNRETGQYIGRTRAWIKQQVYEMMRGRCQHPEGGEKVIVGY
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MNLFVYIAQNPTLTKWFFCCVCTILTMPFFKKPYRKRGISRTPYEWLTYADKCVIELSKSELKPNEEKELPKDIKEDCKTVEEKEKVVPRKPLQSEGINEDDSQKNGELIVLHGINHQAAMLTACGLFMVTSSNTNKWKIAFASFLLGMFFTQFGFQKSERSINAEKLESIEKPENDN
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAPTLELLAEDYASEEDSDFAPETAEAAGESSISDDDDEEAGEDAEKAKPEKRKRAAIEEAEDAGYDNSGDEAIIKKGEKRQKKTKTKLAADDEETGEGGLIKTRSQRAVEKEKRSTAAASGPVTIDVDALWAQMISEPVIPRTSTAKPDESADPANCDIAKSSSQQPETAKAKDPDSDLIKIKRTYNFAGKVHTEEKLVARDSAEAKLYLASLGENAPADGETAAEDESSSAKRMPRKAFRSVFEPITDANSAHRSDLNLSMASRLQAREATGNKAKKLNTVEKSKMDWAVAVDKMGLKDELELAGKSKDSFAARQDFLARSEMRREEEARRARMAQAGKT
The following text describes a protein:
Function:
Transcriptional repressor that binds the consensus promoter sequence 5'-[AT]GATAA-3' during iron-replete conditions to down-regulate transcription of target genes. Represses the expression of the iron transporter fio1 in response to high iron concentrations. Also represses the expression of str1, str2 and str3. Represses the expression of shu1 in presence of iron.
Subcellular Localization:
Nucleus.
Sequence:
MAAKPAPFGQSCSNCHKTTTSLWRRGPDNSLLCNACGLYQKHRKHARPVKSEDLKDISPLIQQVCKNGTCAGDGFCNGTGGSASCTGCPALNNRIRSLNASKSQSGRKSLSPNPSSVPSSTETKASPTPLESKPQIVSDTTTETSNGTSRRRSSHNQHEDSSPPHEPSVTFCQNCATTNTPLWRRDESGNPICNACGLYYKIHGVHRPVTMKKAIIKRRKRLVFNGNANESQHNLKRMSSGDSGSSVKQQSTRDGPFSKSFPNGNGHASGNSGEGLAEHGMNTGVLPPASTFPSYNSNFTGFLPSSFNPSPLMTLSRLAAGEPDNNGKVYYSYGPTQEQSILPLPENKHEGLPPYQNEYVPNGIRANQVVYPGQLVAVGNDSSKQLSESTTSNTDNNGVATANQSNPLGMKFHLPPILPVGESVCLPPRTSAKPRIAEGIASLLNPEEPPSNSDKQPSMSNGPKSEVSPSQSQQAPLIQSSTSPVSLQFPPEVQGSNVDKRNYALNVLSQLRSQHDLMIQELHNLNQHIQQIDEWLRSSDNENMASEHIKSSTPAVVASGALQT
The following text describes a protein:
Function:
One of the multiple factors required for polyadenylation and 3'-end cleavage of pre-mRNAs (By similarity). This subunit is directly involved in the binding to pre-mRNAs, especially on the 3' non-coding region. Required for the targeted 3' processing of antisense transcripts that triggers transcriptional silencing of the corresponding sense gene.
Subcellular Localization:
Nucleus.
Sequence:
MASSSSQRRCVFVGNIPYDATEEQLREICGEVGPVVSFRLVTDRETGKPKGYGFCEYKDEETALSARRNLQSYEINGRQLRVDFAENDKGTDKTRDQSQGGPGLPSTTTVTESQKQIGGPVDSNMHQPVGLHLATTAASVIAGALGGPQVGSQFTQSNLQVPASDPLALHLAKMSRSQLTEIISSIKLMATQNKEHARQLLVSRPQLLKAVFLAQVMLGIVSPQVLQSPNIVQAPSHMTGSSIQDAQLSGQNLLPPLAQRSQQLSRAPHSQYPVQQSSKQPFSQIPQLVAQPGPSSVNPPPRSQVKVENAPFQRQQVVPASTNIGYSSQNSVPNNAIQPSQVPHQALPNSVMQQGGQTVSLNFGKRINEGPPHQSMNRPSKMMKVEDRRTTSLPGGHVSNSMLPNQAQAPQTHISPDVQSTLLQQVMNLTPEQLRLLTPEQQQEVLKLQQALKQDHMMQPS
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKNHFSKLMKNRRGRKTSKMMNGMTKQIQDVMPGGNRLKISLTLFAELTMSSQSLHSTLETLCFLNQLIGAPFSQTRHKLYPTYCKILLFTHLTTLLFTFCNIWWRCSNSQRISTKLIKTLNYFFKVTIIMSTILNSMILKKKNVAQLIPTLKEAKVMLPDVKQKWSCFTHFDSIFVLFSIMTSFIFHLTYKSGCYLIQDLLDDVEMVQSLIVLLTSLKFLELLSNYFDQTNNYFDIILKSEIFISDMKMRRVNQLYRTLYRILELWNNIYGVFLLQLFLHIMVVLIDNLLSLVEEFKLGYSFSWKVVIRSQTIAIYLVLALLLSKIGYQISEKKYKTSKTVLNGLVEITLRGGKQSQLNLLLLKLKTWPNFVSASGYFRLDYGFFLSLLAAVVSYIVILLQLS
The following text describes a protein:
Function:
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). Binds HJ DNA. RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
Subcellular Localization:
Cytoplasm.
Domain:
Has three domains with a flexible linker between the domains II and III, and assumes an 'L' shape. The position of domain III with respect to the tetramer is variable.
Sequence:
MIASVRGEVLEVALDHVVIEAAGVGYRVNATPATLATLRQGTEARLITAMIVREDSMTLYGFPDGETRDLFLTLLSVSGVGPRLAMAALAVHDAPALRQVLADGNVAALTRVPGIGKRGAERMVLELRDKVGVAATGGALSTNGHAVRSPVVEALVGLGFAAKQAEEATDTVLAANHDATTSSALRSALSLLGKAR
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.
Subcellular Localization:
Cytoplasm.
Domain:
The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
Sequence:
MKKILVACGTGMSTSTMIAHKLQEFLTEQGISATTAQCCLNEIPLNCNGMDLIVTSMRTNSDYGIPTLNGAALLTGINDDALKQQIKALLTQ
The following text describes a protein:
Function:
Catalyzes the phosphate monoester hydrolysis of phytic acid (myo-inositol hexakisphosphate), which results in the stepwise formation of myo-inositol pentakis-, tetrakis-, tris-, bis-, and monophosphates, as well as the liberation of inorganic phosphate. Myo-inositol 2-monophosphate is the end product (By similarity). Is also able to dephosphorylate the classic acid phosphatase substrate p-nitrophenyl phosphate.
Subcellular Localization:
Secreted.
Sequence:
MFLLMVPLFSYLAAASLRVLSPNPASCDSPELGYQCNSETTHTWGQYSPFFSVPSEISPSVPEGCRLTFAQVLSRHGARFPTPGKAAAISAVLTKIKTSATWYAPDFEFIKDYNYVLGVDHLTAFGEQEMVNSGIKFYQRYASLIRDYTDPESLPFIRASGQERVIASAENFTTGFYSALLADKNPPPSSLPLPRQEMVIISESPTANNTMHHGLCRAFEDSTTGDAAQATFIAANFPPITARLNAQGFKGVTLSDTDVLSLMDLCPFDTVAYPPSSSLTTSSSPSGGSKLSPFCSLFTAQDFTVYDYLQSLGKFYGYGPGNSLAATQGVGYVNELLARLTVSPVVDNTTTNSTLDGNEDTFPLSRNRTVFADFSHDNDMMGILTALRIFEGVDAEKMMDNTTIPREYGETGDDPANLKEREGLFKVGWVVPFAARVYFEKMICDGDGSGEMVQSEEEQDKELVRILVNDRVVKLNGCEADELGRCKLDKFVESMEFARRGGDWDKCFA
The following text describes a protein:
Function:
Possible role in granule neuron development.
Subcellular Localization:
Cytoplasm. Membrane; Single-pass type II membrane protein.
Sequence:
WRSFNYKKLEVPSNIILDATSVTPTTGKVSVNGLEVFYREVRPEDESPYVSVLLLHGQAFKSETWQTLGTLGVLSRLGYRAVAIDMPGQYPHCGFCACVCTRHIEDPVEFVAGLLSALQLHNPVIVSPSLSGRLSLPFLVSRSKQLAGFVIRFSPLPSTVPRLDSSRLSTQVPTMVVFGEHDRSTSSALLHLLPRSTAVEIPHGRHPAYLDNPNLWHQVLHNFLARLCHEAQQQHATKG
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MDSWDDDEFEVPSVTETQQVAANWDDEEEEEEKPIVAAKSEPAAPKGPLKPKQLKKMKLKEIEEKQKMEIALTKARLAAQAEETDDQRRAREKASIEEADFEMAIDAFAGAPPKPTVAAGDDADAAVSALRLLSLADHEHLGDVVSSRLATSNSKYALECIKVILTKASVNLTADDMKEITTIVNVIKNDKIASAKPKGKKKKQTGKQGYANVERNVGNGGAGGKSYAGFEDTYDDYDDFM
The following text describes a protein:
Function:
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Sequence:
MIARMSTRRRAREIVLQLLYEADLNDWRDAATSRKFIRSRLQGRKVLTDFAAELLDGTMARRDDIDAKLTKLSTNWALHRMPVTDRNVLRLGAYEILYSGTPGQVAISEALTLAKRYGGENSPRFINGVLDRLFKYHSNPESVSS
The following text describes a protein:
Function:
Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity).
Subcellular Localization:
Mitochondrion matrix. Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes on the matrix side on the mitochondrial inner membrane.
Sequence:
MAFRVSISTFGKSLRVRRVANVSAPLANASPFLRTGWAARPPGTNNGHGFRFTPACFITSDAFLSRLAKGKAETDDTHYHHPASVLPDSAEQLSLLVKDPDQPENSKVLRVAIIGAPNAGKSTLSNQLLGRKVFAVSKKVHTTRARALGVLTEDDTQIILLDTPGLTTPTKVKRHQLEKSLLEDPWNTVKEAGLVVVMVDVSDKWACNKLDFEVLKCLTQHPDVPAVLVLNKVDLLKSKSRLLEITADLTCGVVNGRKLQVRRVIKPPWAERRTDREARTSGSGDEEKPGGDVADGEGSEALSGLSKEQLRALKTQQGWAHFKDVFMVSAVDGEDVETLKRYLVVGAKPGSWQYHSDVLTDQTPEEICTNTVREKLLEYLPKEVPYTMTQAIDLWHDRENGELDIAVKLYVKKESHMKMVIGQAGQMVARIAREAGDDLSTVFLREVKLRLSVKVKN
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MVKVFFVLAVLSSIISYINIDPMKSSFFLIFSLLFSMPVISMSMHIWFSYFICLLFLSGIFVILVYFSSLSKINVVKSYMAVFLLLLSMLYFSPTVLTYSSYLGLSGFYYSIYWFIFCFILVCLLFFMNFSSYFLNFSGALRKV
The following text describes a protein:
Function:
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes The CSN complex is involved in the regulation of the mating pheromone response. PCI8 may also be involved in transcriptional and translational control.
Miscellaneous:
MISCELLANEOUS: Present with 504 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFHGAKGPLLIERIGHLLSINYGEKEERKRWAMQGISYLQEVQCTSTPYLEILVEESGLRPVSLLNSQLVGKPHFSLLGGFDENIARDIISHNFQNAIFQMESEEVPLTKRYQHLEKITQISLLCKNFKGIEEIEYNVKNIIQGRKNFDMLNSMEKDRISHEVVQDDSFSLLRIQMLLCVSYFLQERYFDCCTKFFTMMTSEPLTLKVLSEHLDCMNFISKEEFIMMVNISVLISIPLDNYDDFIYLSDLKQFFQMTPLLVNCLELLINTNFNKFFKIWHGEINKICMESLFLEPSWSSSAAVIMRCKIYFFYLRISKKLQFSYLSSTLGIDLEDIKEELTKLIISGQLNFEIDGDVIHFEDSSILQSIVNEISRNGTMINEVIDKLKNENTDLKDIIQGNPLMYSGGNNTATIINNESSDDMDIDEVNDRSDISDSEGGLFEC
The following text describes a protein:
Function:
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Sequence:
MKVYLESFGCSASLASAEIMKASVERLGHELLNPAAAGEAEVYICNSCTVKYTTEQKILYKIRSMGEKGVQVIVSGCMPEVQLEEILHANPEAHILGVNAISRLGELLSSIEQRRMEGLPAGGHLELRTSEPLGFLNVPRERSNPNIHICQISQGCNFACSYCIVKHARGKLRSFPPEKIVKDIRSAVADGCREIWLTSQDDSQYGMDTGVKLPELLRMISEIPGDFKVRVGMMNPFSVLPILDGLVDAFDSDKVFKLLHLPIQSASHSVLKKMNRLHKMDAVDEIITKFRARFEDLSLFTDIIVGFCDETDEDFEETIEWVKKYRPEKINISRYSPRPHTKAFSFRNLDSRISVQRSHELHKVCEQIKLGSKQEMIGWKGRVFVSKYTEIGDVLTRTDAYRPVVISGSDLKPGEYANVEITGAKPGYFLGRIID
The following text describes a protein:
Function:
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of tel1/atm upon DNA damage. The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (By similarity). Within the MRN complex, nbs1 acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites. Recruits rad32 and rad50 components of the MRN complex to DSBs in response to DNA damage (By similarity). Promotes the recruitment of tel1/atm to the DNA damage sites, activating tel1/atm function. Mediates the recruitment of phosphorylated ctp1/CtIP to DSBs, leading to cooperation between the MRN complex and ctp1/CtIP to initiate end resection.
Subcellular Localization:
Nucleus. Chromosome. Chromosome, telomere. Note=Localizes to DNA double-strand breaks (DSBs); recruited to DNA damage sites.
Domain:
The FHA and BRCT domains specifically recognize and bind phosphorylated proteins.
Sequence:
MWIIEAEGDILKGKSRILFPGTYIVGRNVSDDSSHIQVISKSISKRHARFTILTPSEKDYFTGGPCEFEVKDLDTKFGTKVNEKVVGQNGDSYKEKDLKIQLGKCPFTINAYWRSMCIQFDNPEMLSQWASNLNLLGIPTGLRDSDATTHFVMNRQAGSSITVGTMYAFLKKTVIIDDSYLQYLSTVKESVIEDASLMPDALECFKNIIKNNDQFPSSPEDCINSLEGFSCAMLNTSSESHHLLELLGLRISTFMSLGDIDKELISKTDFVVLNNAVYDSEKISFPEGIFCLTIEQLWKIIIERNSRELISKEIERLKYATASNSTPQKIIQPQRHIQKNIVDDLFSVKKPLPCSPKSKRVKTLENLSIMDFVQPKQMFGKEPEGYLSNQSNNGSAQNKKSGDNSEKTKNSLKSSSKKSANTGSGQGKTKVEYVSYNSVDKGNSSPFKPLELNVVGEKKANAEVDSLPSENVQESEDDKAFEENRRLRNLGSVEYIRIMSSEKSNANSRHTSKYYSGRKNFKKFQKKASQKAPLQAFLSLSEHKKTEVFDQDDTDLEPVPRLMSKVESIPAGASSDKSGKSSISKKSSNSFKELSPKTNNDEDDEFNDLKFHF
The following text describes a protein:
Function:
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.
Subcellular Localization:
Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MNNLHNQHHLAGGNFAHPQFFNQHGNQGKRKMNNDPNRPKRPTSAYFYFVQLEREEAAKRGERINRVADWTKQVSAKWRTLTNEQKEQFQVLAAGDKVRYSQQMAVYTGKDANRPKRPQSAYFLWLADFRVRVKDKFAEHKDILRAAGEEWRKMTMDDKAPYEQLAEEERKKYDIKIKEYNQVMMTMMMMVNVIMMVVMMTE
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MLPVPAADVTEVCTICAENRFSSEMVTVSGCDHRFCVHCVERHAAVKVTQGEVNIRCPAVNCAVSFSDEECGRLLSEKTLEMLAKRVKDLSIPAEYKVYCPYKDCSEMMDRRELEVSESTSSFSSASAPARACVTCSRCENKMCLRCNVAWHVDMSCDTFQALPAHLRDVEGALLHTLAKRKQWAQCERCGRIIERDGGCEHIKCKCDYEFCYMCGKKWIRANHSCVRAFN
The following text describes a protein:
Function:
Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Involved in centriole duplication (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MAVDGLPITEQWIREKLNLQHRCLADVRSLTLPGTYEGKICHLGTSLKNFVRLKSLDLSYNALVTVQGIEHLELLERLNLYYNRLASLQDIFSLHKLQNLKELDLRLNPVVKKHPHYRLYLVHAIPKLRRLDDCPVRDRERKAALMHFSSEENLDSDYKKQVFIQDTTARSSDLRIKAMQKMVKTLSLLEGNEELALNDSSRKTGKRRSLQTLSVRCENECSPLLAHENPSESDIVYLFNDSDCRRSSKHKQESAPSKSSDYKNDARAGPHRVRFVSPVILRHSSVRGESVFTAHPDSHKQPHSHENDCSSPKWQNQLLDRANLVLHPPRLTYSTAETKDRSTKTLKGTYRKPMELLLSMMEDLWSEKKENQQNRTFLMKMVQILSMMEQEVSGGEQEIQTLKAALKASIAQADVQEKQHQSEIEELTLQQQQAHESIKRLNEQTKSLLEENVSLQKQLIRAEHKLLASRLKNIPHTQDRGVQSVPEEFNTKRDIIADDEDGGVGEQQQSYRSLIARNERLLQQLEEALMSK
The following text describes a protein:
Function:
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
ATTELKSAISQAKLGQIRLIKMIINSENLSLEKVIKPIGTWQQDFDNAVLPCLKVNQPCYILYKLDSRYQQDGSPEWLLITYVPDTTQTREKMIYASTKMTMKKAISALHIKYDYAATTINECSYEGFNSYIRSLTAPKPLTKAEIELQQIKKNEMRTQGKKQTLQSISFPLTPELEDALLLFKSAEVNYIQICIDIAKEVISLAVADKITTAQLRNLIPTDKPRYHLFSFNHRGNIFIHSIPVGKSTIKEKMLYSTCKMTFLQRVEADLKIPVARKIETDSPDELTEEYLVDQLSSSSSSSSFPPAARFNSSGAVGDVNFRHQRMFHNLGSPAFH