lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSTANGGSLDDCITNLFALTELNGLQWRQYECPSWNIDSNPRTLLQNEPILVAYSKLQSDGILSVWRRVVKKSPPTVVNLLPTLDGTAPKELWVFWYGATEPEEIEKHCKDLIKKKNEDESEDGTVTGIPYDVRCLLYKSWNTQMEKHYRRKKFLQIGRWFVRPHKLIDPSIAFMIDDFVLAHCHSFNIVGGNSMCMAIKTQLQPNLVHIAPFHIERNKKNKDSRINVLLAPWSLNAHVSLRYSITPITKKEEEEVEKQLTQWKELNMFADQKRKKRRREEGGDTEGEESEDEGWGDIKTPKMIRVEVDGKQRMWWPTQYVLVTLEETRRIVRDRFPVADLLKCVPEKVSMFSRNRFAHLTNSDGSVRITQSVVDDSNFNMIENGKKIEMGLPKPDADIVSVYLTKRRLSDRKKKRKTQLTFEDRRRRKLENGMGAQRMVRVSSVSTDEGEDEGKEPNMKKEYKRMMVPNRFNCRSKNGRKNSKKETALRSMGLSSSDDDEEAEKKEVIEEKPEREWKYDNEKAIKIPRDISSMQPMQSIRALHKSTSKYRRKESNEIADESRLSKSKFTPVRALTPSSPQSEAAESEKFRSDASMSMGFQNEYTSYYDKKAAEMVPDIKYKPYHSRRNGPREHKERTRNKTDGRSRIDEVCSSDDDLLGEIHSCKRIREASPDVKPPRSHVIPDFEMEEVGGVNIPPPLDIPPDTVIREKKTSLFHPLRRSSIQFPELEGGDDFIELHYLKNLENRGYDIGSDEEPSDDRYSIGSDLQPPISTAVIDDAGEGTSSGAENWPRDEDEDMQDEYHHMDSSHDLMDTEGPSHSDSVLSPPASNERADSNNSMYPRLPGGPHSVGDTALNRIYPTPPSLLQVDICSPANMGGPHSQARKDDRDDASSTHDDEDDMQFLGDIELKDEDDSRGDHQIMNLNYKLHSRQFFDNAPKSDVPLSTRFGTHKHRSRVPEKRALPVYNKKDGERKEQLTPRIEEALAGADNFTTLSKISTSATAVGGQGWPSHAHQMSHPSMISHQQMQHQQQLHGSQSGPSMGTPPQSLHPMHPGYMGGTGQMGSFPGQPAGMRQSYTPQGYGVALHQQMQQQQQQYPMGGAQMMMGGQPGQSGYHPGAVRPPGYPGYPAQTGVPMGGNHPMQTPGMPMGYQQGMQNQMMYRPGMPTGSYPPQYGSPMGGMMSGGNGMGGMQMGGQYPGGGPMQQGGMMMQQMPHGQPMIAGAPHPMGMPGMTGHPSFPITSSAPGVIPPTSSAMIMMQRAAEPLKKNRPLALIDEEQTLIASRRGEDPYVKSLSIAPKGLFYKGNRQLKNEFDLYTTELILAKEGRKERRPFGPPTGGSEGLSIVAAVMLQDTILNLHFDWVFDSCPICACTTSIRSKELGVYITPPPILEETVEVQNVWIGTWHGMHLESTDSNICICGFSVIRHRLLSMRSGLFIEDSHEATGDLDSRTNPSKGKETKYLWFNPSSAADHALVETLRSMALTTDIGRLVGAIRNISTMGMKNAKRRGRRRNRNKKIPSIGPIGSSSEYVISQMDKMEVLLMGNSALTSAHVSGNKPTPSVGETPYFHPWGLQIASDVADPTEMEIKNLLEDVKPLIEGAVREARKLTTSTSASSVIEGPLTWRSLAAKNVKCSGNGDDDSHIAEPIPLLEMATEKDAIRIAPTVMKNWEQHNLGPIDVPKDVLYLAVTPDDDKVYDMTVVYVRRISKMYEQNLRLGRHTGYLARDEPNKTNVREGIVRAGVARSQHDSLDSPSLLFVREVEKEAEKHGCSKEFIHKLVTYVQSVEEILVEHLQKNCRIFERDVFRECVGSNLYHRRQNQKQKNTNPATFRNEVDRDDASPMQIDESRKAESIMFNGPLAEALGMTGGSSSNSKAKKKVKRPFGHCSPYGMVGERLFKIPDEEPAALPHIVVIYLGRNGDAARVAMIAIVKAFNSVMRKLPGKHRGQCQLELIPIQLVEESVGSAADLDRLDRSNNLNTWQIGNMHRSAEIYPNDRPKIEDVLKEIAFGIYRKPRFLHCDALKNALPKSMTKFGPASAILDWIDKKDGKKMTMYKCHSVPFQLANTPAIIAKSEAKFSQLCMDEISLYISYCLVSVDFIVVTVTDNLGARSDSAVLNLKPNIDQIGSTFRSQNKSSVVDGLHKLWKYIEGVMLHESKPLRLVIGKLGKMGHGEFKAWCHVLSRSNLKKYSTRVRESCSPCNANAGAPILLSACLVSTEPEAHLQVLPSYSISPDPNGSQKKIRPLHSPGDNTITHIMVFPISPAIQLNQSKENGGAEDEDDFSALDDIPDMEGNDMNDIMNDILMNKEEEGEGRAAARNHHMNSFFDAPLESGVQNQPLAAGWMISTAPGGDLPDWFWSSCPSLKRRLPVHLRSSLHINESQLSKSDDIGMKKEKEQEISHALDSQKTDEVLRHVLEQYNDLSWLAIDSITQERRSCLPIHIQALTRLHDTVINLIM
The following text describes a protein:
Function:
Acts in maintaining the cortical microtubules organization essential for anisotropic cell growth.
Sequence:
MSRGGSAGGGQSSLGYLFGGNEAPKPAAKPAPAAAPAPAPAPAPAAAVAAPAEKPSPAKADATKQIPAGIQGSRSNNNYHRADGQNTGNFLTDRPSTKVHAAPGGGSSLGYLFGGN
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MASYKQNLPPSAVVRQHVSLADKKSKAEVQRDRQLEEDRKAGTAPAMVDVQTGRDINPHIPMFISQNPWYVPSEGPTLKHQRPHEERQKNMTQIHEWYQKGTTGKSATKFRKGACENCGAMGHQKRDCFDRPRKSNAKETNANIAEDDYVQPKLSLGFDAKRDRWNGYDPATHKQVIEDYEHLEEARKVVKEHEMKEGESEVPTTEEGAPKDEDMYAEDADMAGVSVDMDSRTRITVRNLRIREDTAKYLYNLAENSPYYDPKSRSMRENPFAGVAGKELEAARFSGDNFVRYSGEVTAANEAQVFAWQATRGGVYAHSIAEPTKLEALKKEYEKGKTTLKNETQKELLDKYGGGEHMERPADELLLAQTESYIEYNRKGKVIKGKERAAISSRFKEDIYPQNHTSVFGSFWREGNWGYKCCHQFVRNSYCTGKQGVDAESSAAKGTTTSNEQVFKAPKLVEPTEVKEEEMVKEESEEEEESVEPTKSPTPSDDEEKMKQYEEERRLEKERREREQRRRDKNREKRGRKKAKLGKRKRRHRDSDEDSNSSGSSDSESDSDKERKETRRALKKANRERAEGMKAAKEGDRGRKYNTDYSNTAPTEKEMEAYRMTSVHSADPMAAYMNSKFEKKHCK
The following text describes a protein:
Function:
An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
Subcellular Localization:
Cytoplasm.
Sequence:
MYTAEQKARIKWACRRGMLELDVVIMPFFEECFDSLTESEQDDFVALLESDDPDLFAWVMGHGRCENLGLAAMVDKIVAHNLSKVR
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MADSSVNMSKRLLTFRDVAVDFSQEEWECLDSAQRTLYIEVMVENYTNLVSVENYSIRGTVHRPLRTEKVSCQSNKRGEIFHGSSNCVLYKRSDTTETSNNYRCCKDRDASVDSSEPGQHTSTHTGEEPCEPKDCEKSSSLCSNIAQDQRTNTANKEQRQEKRDDHFSSTHSLIQQIIYIREKRHQCAQCKKSFRTSANLTIHQRIHTGEKPYKCNFCDKAFAQCTTLKTHQRLHTGEKPYKCKECGKSFPQLSGLKSHQKMHTGEKPYKCKDCDRFFAHCSSFRRHQKTHSAKNKQHYTDPNCGKDLHQLSHFKSHHSLHTAEKPYRCSDCDRSFTHYELFRVHQKTHSSEIDYECKKCGQSFTELSELKRHYIIHAGTKDYKCRECDKSFTQYSTLQRHLAIHIGERHYKCKECDKAFLHNSHLRRHQSVHTGEKPYRCKECDKSFTRSSILKQHQKIHTKEQPYKCVECDKSFSQPTHLRTHLRVHTKEKPYRCTVCDKSFTTSATLRIHHRVHTGERPYKCTECNKSFREGTTLRAHKKIHTGEKPYKCKECDKSFIRYAHLQRHQRVHTGEKPYKCMECGKSFTECFLLRKHQRIHTGEKPYKCQNCDISFLCISNLRQHQKTHTEEKHPVVNNVI
The following text describes a protein:
Function:
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MVQLFRTAYPPTTYKAHICSCAFIFRAICWLITYVVPIIICVFYYFNQSQVQIDQEYPTYFPGDIVSVSLIKNTTSGSIESLSYPADIPKFLPMFEVAQEVDETGNITASTVRVRAEITDDSTIIGVNIIFAYNVSLRKWSRSDTSSYGFFAQQFPQGVEKITCQGVLSLYQEKAVDFRGSLPNDVIPSMNHINVQNLLTAQSNVSSLYFITWRDHVPQYRVASSGKYTFECYLKIMISDITIMHSLPLVSIIESIIILWLSTHILVSLIVGFIQHHTFYNGIVTTIKERHYTPTSNRSVRH
The following text describes a protein:
Function:
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGADGQVNAGEEKKADCGKKKMKEASGDEGRAELNPWPAFINERLEMYNKLKAEHDALLAERAANDSKPIKVTLPDGKLVDAESWKTTPYQIACGISQGLADNTVIAKVNKMVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERIYGGCLCYGPPIENGFYYDMFLEDGGVSSNDFSALETLCKKIMKEKQPFERLEVKKETLLEMFKYNKFKCRILNEKVSTPTTTVYRCGPLIDLCRGPHVRHTGKIKSIKIHKNSSTYWEGKADMETLQRIYGISFPDAKMLKEWEKFQEEAKNRDHRKIGRDQELFFFHELSPGSCFFLPKGAYIYNTLIEFIRSEYRKRGFQEVVTPNIFNSKLWMTSGHWQHYSENMFSFEVEKEIFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCSVEQIEEEIKSCLQFLRAVYDVFGFSFKLNLSTRPEKYLGDIEVWNRAEKQLENSLNDFGEKWELNPGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLSIRFNLTFVSHDGNDKTRPVIIHRAILGSVERMIAILTENYGGKWPLWLSPQQVMVVPVGPTCDEYAQKVRQQFHDAGLMADIDVDPGCTLNKKIRNAQLAQYNFILVVGEKEKASGTVNIRTRDNKVHGERTIADTVKRLLELKCSRSKQAEEEF
The following text describes a protein:
Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.
Sequence:
MKINILKKGKKFYITNNHFNYDIKRNFTIFQNSFIKTNDIVYRKNIDIVCAKDLFFYTILNVDRYKYFLPYVTDSKITEKNKEYFKANLQIENIFFKEKYDSLIQFIYPTTITVSSEDTNIFHHLITEWIIKEKKNCINIDFYINFRLKNKIYQNFMNLYIKELGKKILYSFINESKSNSYKNTDVLHLIK
The following text describes a protein:
Function:
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Cytoplasm.
Sequence:
MGKPKFYDFCVHAVPDGDSTAQEQVSLGRHFGFSGIALANHSDRLPDRKPILPFIEGFEVFRGIELVEENPSKLHSLIGKFRNSMDVLIVHGGSEAVNRAALENPRVDILNHPAFDRSSGLNQVLAKAAAENGVAIGIILRPLLHSRGSRRIRLLSDLKSNLELARKYDVSLVLCSDAMSCFDLRSPMEMLALAEVCGLEEDEALEAISTVPEKIIAKNRPGPGYIKKGIEVLEGEDLF
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Miscellaneous:
MISCELLANEOUS: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNPYLNAFLRSIIEAITEFLPVSSTGHLFLFSSFFPFYGENVEFDDLFDIFIQSGAILSVLFLYREKFKSQIVSSFRYILKQNSDSEGFHFLIQICIGAFPILIAGFIAKKFLDTIKARPDLLEILSGAWIFGGVLILVAEWYFHQRPEEKKSIGFKDSILIGIFQCMALIPGMSRSAATIITARFLGKDTKSSAEFSFFLAVPVLLAAGIYKLIKYRSILNGNTIPVLMFGFLVSFLLCTLVIRWFLRYIQKHSFSVFGVYRILLGVGVLVLTKLI
The following text describes a protein:
Function:
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
Sequence:
MKLKTGLNLTALLLFMISVAFPAQADTQKMYGIRGDNLSIATQMPAPRTYSVKGQTYTTKSGNEAKSYIKEGLASYYHLKFDGRKTASGDVYNSKQFTAAHKTLPINSYALVTNLHNNRKVIVRINDRGPFSDKRLIDLSHAAAKEIGLISRGIGQVRIEALHVAKNGNLSGAATKTLAKQAKTQEAADRLVLKSNTLFDNTSKSINALKGTEFYCLKMLELTSRSQANKLITQLALANIQTEVNRSGNKYEIYIGPFDDKTKMAQVRTKLQKMANNKPLIVYTYKN
The following text describes a protein:
Function:
The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MQFLNMFFFDIYPYIAGAVFLIGSWLRYDYGQYTWRAASSQMLDRKGMNLASNLFHIGILGIFVGHFFGMLTPHWMYEAWLPIEVKQKMAMFAGGASGVLCLIGGVLLLKRRLFSPRVRATTTGADILILSLLVIQCALGLLTIPFSAQHMDGSEMMKLVGWAQSVVTFHGGASQHLDGVAFIFRLHLVLGMTLFLLFPFSRLIHIWSVPVEYLTRKYQLVRARH
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil.
Sequence:
MKKYIVEHEYDGYEIGTYLKETKGYSSRGLRNLEIYLNGKRIKNNAKKIKKLNRIVVIEKEKSTGIKAMDIPIDIAYEDENLLIVNKEPYIIVHPTQKKVDKTLANAVVNYFEKTLGKTLVPRFYNRLDMNTSGLIIIAKNAYTQAFLQDKTEVKKTYKVIASGIIEKDDFFIKIPIGKVGDDLRRIELSEENGGKSAKTHIKVLEKNYEKNITFLEARLYTGRTHQIRAHLSLIGHSLVGDELYGGDMKLAKRQMLHAYKLEFQNPKTLENLKIEIDIPVDMKEVLK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1. H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is a prerequisite for H3 Lys-4 methylation (H3K4me). It thereby plays a central role in histone code and gene regulation. H2B monoubiquitination (H2BK143ub1), mediated by HUB1, modulates transcriptional regulation of anther development, likely by promoting histone H3K4 dimethylation (H3K4me2) in the chromatin of the key tapetum degradation-related genes C4, CP1 and UDT1.
Subcellular Localization:
Nucleus.
Domain:
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Sequence:
MGSTGEPDRKRRLSSSVAPGGGAPVSPAKRLAVAPTSEDKKLDFTVLKYKNQKLSEQLEAHKFEYRALENKFAGLKEKQRTHNETLSLVNSSWEQLVADLKSRSFCKSGSPNSSPGSGHNNVQKDGTCAPIERDTLRSLVESGATESSGCLPGCHLGSDAPPLHLSTANALGDIFFPSSDLLQANEECALAALTKLPENDRSKQLQSTSSNLLSSLNNVVQALSNLQLKHKQLAEDYQNQRDSSARKRAEHRRLKEELASAASELEETNYKLAALKAQRDNTQGARIPYPTLGNKNMPEDKVRDKQREMQDLEATHKELSELISKRLVEIKRLHEERIEILNKIATFQNILMDFKSIRSSKAFQLVNDRLQKSQAELDHYQTLLEKLQVDKDKFVWQERQFNLKVDLAEIPERVSTYCESSIADLKKDIQKLCDEKNMLILKLEEASREPGRNQVITKFKALVSSIPREMGAMQSEMTKHKEASLELNSLRAEVHSLSRILSRKERDNEEASCRSARAGSDITQLQSVISDLKQTNKELKLFADMYKRESTDSREIMESRDREFLEWAHVHALKSSLDESKLEQRVKAANEAEAITQQRLATAEAEIAESGQKLGTSRKDLVSLSHMLKSKQEECEAYRVEVECIGQAYEDIQAQNQQLLQQIIERDDDNTKIFMEGVKAKQTQDALHLETYSLRRNLQQESSLMDLYNQKIVSLEDQLKMWSDRVGKLQEDGWQQSVSLSNYQRKLVDVHRDAQKLMQSLDGIQANVGSSRLEVADLLIELEKERFSKKRIEDDLEVMSRKASSLRAKARESAVLEKLRHEVKEYRGILKCGICHDRQKEVVITKCYHLFCNQCIQKSLGNRQRRCPSCSLSFGANDVKPIYI
The following text describes a protein:
Function:
RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating splicing of S-adenosylmethionine synthase transcripts (sams-3, sams-4 and sams-5). Able to N6-methylate a subset of mRNAs containing the 5'UACAGAAAC-3' nonamer sequence. Plays a key role in S-adenosyl-L-methionine homeostasis: under rich-diet conditions, catalyzes N6-methylation of S-adenosylmethionine synthase mRNAs (sams-3, sams-4 and sams-5), directly inhibiting splicing and protein production of S-adenosylmethionine synthase. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA). Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development. Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate. Plays a role in the development of the vulva, somatic gonad and embryo.
Subcellular Localization:
Nucleus. Note=Accumulates in nuclei as cells enter meiosis. During meiotic prophase, expression is predominantly nuclear, but does not co-localize with DNA. Recruited to the nucleus by dlc-1, a component of the dynein complex.
Sequence:
MSQNNEMHPRNPYRNKPPDFKALAVEYPEFRKFCQYVSNGKVTFDFKKDAAVRCLTQTLLKKDFNLDVEIPPGHLVPRVPQKLNYCLLIDDLLKANKLTKNVIGIDIGTGTSCIHALIGARQFNWKFIATDGDEKSVRVAHENVAKNGLSSSICVVHVNPDVKTVLMDVVNTIPDTDYAFCMCNPPFFEKGNGDDKFCEDISSSTETYSNRVASEFRTAPHSATFASSAELFVDGGEVAFVNRIIDDSVLLRDRIKIYTTMIGRKSSLKPLQNRLQRFGDDVKIMISVLNQGKTKRWMLAWTFSKSVSLTTIDRPISFQCPKPGLTRLMQEISILNGRLRQEDTLAIVAEFKCVTWTNQRARKRAKAILSESSIKKAKWNFSNVACQVAFGAGDGKDSYTDAGNFVSSESIPTNNLNAWDNASQAYFPLPNGEVPGPIIRIRIQVFSEDSYDSISFELISGSKQHLHQLVQYLKNLICR
The following text describes a protein:
Function:
Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MKYARGMTLLEVIVALAVFAVAAVSITKSLSEQMANMPILESRTLAQWVADNQMVDARLDPQFPEIGKKEGQVELAGKDWYWRKEVVKTTDDNFRMIRISVSEDERYQRIAAQVSSYVLKTN
The following text describes a protein:
Function:
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MIEPVRVIGGGIAGAEAAWQCARAGVPVVLSEMRPVRPSPAHHTDHLGELVCSNSFGAMATDRAPGLLKEELRRLGSLVIAVADAHAVPAGGALAVDRAVYTRELTERVANHPLIELRREEVTEIPAAGLVVFATGPLTSEPLAHGLQALTGLGYLSFFDAASPIVAGESLDTEKVFLASRYDRGEAAYYNCPMSEPEYRAFWEALASAEQAELKEFEHEERKFFEACLPVEELARRGYETLRYGPLKPVGLTDPRTGRWPFACVQLRQEDRAGRLWNLVGFQTNLKWGEQKRVFQMIPGLEQAEFVRLGVMHRNTFLCSPHLLAPTLQFHAHPRLLACGQLTGTEGYTAAVAGGWLAGTNAARLAQSRDPLVLPVETMAGALVDYVSHGDPKTFQPMPPNFALLPEITPRIRHKQQRYWAYRDRALAAIDTFGRTHGLGAAPALARAN
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MTKVFLPLFQPLNFLLCDKHNTHSTCPSEHSETKARTELTHGDVAVVMAALGLSFNAEGNEVEDEALVLLEEKQASWEELEEAFSVFDGDGDGFISPLELQNVMRRLGLQHDAGHEECERMLKVFDRDGDGMINFDEFKVMMQGVV
The following text describes a protein:
Function:
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
Sequence:
MNLTIYLITDDKYFKDRDLFNTIEQALQGGVTAVQYRFENKTTRQMYEELVKLRELTRKYNADLVVNDRVDLALAVEADGVHIGKDDLPPEVVRKIVGDKMYIGYTANSLEEVKRAQELPVDYIGFGSIYHTSTKENYKLVGVEALKEAVKISQKPIVCIGGIMPYRVPEVVRAGCRNIAVSSGILGFADVKKAAESIKRAYQETLRMLMLMGKV
The following text describes a protein:
Function:
Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). May down-regulate activation of NF-kappa-B (By similarity). May have an accessory function in the survival motor neuron (SMN) complex. Required for neuromuscular function and organismal viability.
Miscellaneous:
MISCELLANEOUS: 'Valette' is named after a Grand Master of the Order of Malta and distinguished warrior, Jean Parisot de Valette.
Sequence:
MSINWIKITERAREGIKIINALPYETFTTVLFYTHRQMSPSVASASATSSTVGTSVTTTGRVDSSTEENPTSNTEPEYTLEELERLVGVPRQDFLLLIKTFSYILRRISTFIIKPSLLQRELREKLQLEDEAKIDAILRLWVRETTPIMNNLASKRYESNVIEDVAWKLNMEISSHCQQREKTPLAVLQMKTAVGEDINIEMTQPELMELYNQFESIQGELDAMLAMKTTGATAPGNQ
The following text describes a protein:
Function:
Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation. Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well. In addition, displays an alkaline phosphodiesterase activity in vitro.
Subcellular Localization:
Apical cell membrane; Single-pass type II membrane protein. Secreted.
Sequence:
MDPQSEIGMHQRGHLDQVILQPMDYVKKKTLQKYKIICGVLLGALVIVSLGLGLGLGLNRGAQEQVSCRHKCNEPYRKEVAGCQCDSGCKERQNCCWDYEDACVEPTRSWSCTNFRCGETRLPGSYCSCSDDCLQENDCCVNYNTVCKGEIPWVEEPCVSLETPQCPAGFDLPPLILFSMDGFRAEYLQTWSSLLPNIEKLKTCGTHSKYMRAAYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKHFSLSSTEKFQPSWWKGQPMWLTAMYQGLKAGTFFWPGSDVPINGTYPNLFYLFNSSVTYQERISGVLKWLDKAKSERPDFYTLYIEEPDSSGHSFGPVSGGVIKALQLADETLGMLMEGLKQRNLHNCVNLIVLADHGMDMTYCSQLEYMTNYFNQINFYIYAGPAARIRASIVPQNYYTFDSEGIVKNLTCKRSPQHFKPYLTPNLPKRFHYANNIRIDKVHLLVDRQWLAVRDNSYTFCDQGNHGYDNEFKSMEAIFLGYGPSFKEKTEVDAFENIEVYNLMCDLLHITPAPNNGTHGSLNHLLKKPFYNPSYAKEESSPVSCPVSHLNPIDELGCTCKDVSNASVINKRLNLTADEIKNATSYNLPYGRPQVLQKENIYCLLPHHQYVSGYSHDIWMPLWTAYTVTKPESTSSLPPTVSDCLRADVRIPVAHSQNCSNYPEGLDLTYGFLYPPNFNSSALEQYDALLTSNIVPMYRAFRDIWDYFHDVLLQKYARERNGVNVISGPVFDYNYDGHFDTLDEITQHVNNTQIPVPTHYFVVLTSCKDTSYTPLNCTGSLDALSFIIPHRPDNTESCADNRSPSEWVEERVQAHSARVRDVELLTGLDFYQERQGPVSEILQLKTFLPTFETEIN
The following text describes a protein:
Function:
May play a role in muscle cell metabolism.
Sequence:
MPPRSEVIPVSTLKIKPPPNRSPAQNGALWLKDKEVTDGAEGLWRIHDDLYDFSDFIRSHPGGSEWLELTKGTDITEAYEVHHLSTAPEQILKKYLVRKAKTKRNSPFTFKDDGFYRTLKREVASIVKTLPKQPINNSATFTDFLLAGTFMFAVLANTYWNYYLAIVAGVFLGCLVIAAHNYFHKKDNFRMLYFNLSLMQTREWRISHVLSHHLHTNTIDDMEITMNEPLLPFLPHEKPPIIKYGYYLFFPIYWLMAWHANFLKRVYYIAKGDTHLIQWYDFVPYTLPLAMYLISGQSIFATLWMWTVIVAIGSFHFSAVGLNAAHHHPDIFHDGDAPRSDTDYDWGLSQLDAIMDRHEITGSHFLVLTNFGDHALHHMFPTLDHGTLELLYPTFRKVCQDFNVDLRMTSQLELIKGSFMQVMRTEPNPNPPDLLKKY
The following text describes a protein:
Function:
Histone methyltransferase that monomethylates 'Lys-5', 'Lys-8' and 'Lys-12' of histone H4 (H4K5me1, H4K8me1 and H4K12me1, respectively), thereby controlling gene expression and remodeling chromatin structures.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm.
Sequence:
MGQSSLKLETIPLNDCHFSDAAPVGSVIPTESEVYDAVAQLWRQEPELERAGWEEWRARLKAIHPGWSLSVAHICRTLEKHCMSITGITQFTYHELVTSKESPALREPHLAKVQVTWSEKGKGLVARRPLAKGELVFAEDALSFIPPLEKSTLVHLSKACGSCGTSLSQNRYYYVMNNLDCDNCTTIWCTKGCRNLDTTHDFLKHPMSRNKRCSAQKWLKFEQFCKENTWHSAYSVGVMFARYYLHSDRRLQGNFESLAEVSQRVRLHAADTMNSGAAFDLGVDLTANAQSVCMWEEGYGLFCDAFPLAKDEYDLDFEKFLRYVGKFNLNQVNGQIYMLLSHLNHSCEPNIYYELEGHHINVYARKEIKSDEELTVSYVNPLHDVDLRRRELRVNWGFLCLCDRCKREISKKNIDKAGHSSTTAGPEPQSYRGHRRKSSLRASKPTLQDLLENGKEFDIEIPSQPGFAARRASVRFDSKVVTAVEERQ
The following text describes a protein:
Function:
Serine protease inhibitor which plays an essential role in regulating the tracheal melanization immune response to bacterial and fungal infection. Acts by negatively regulating a protease cascade involving Mp1 and Sp7, that functions in the activation of the Hayan-phenoloxidase (PPO1) cascade.
Subcellular Localization:
Secreted, extracellular space. Note=Detected in the extracellular space at the apical surface of tracheal cells.
Sequence:
MGKIADCLMLWIPLLLGAIFLCSADPQNNQAPLQLSVGNPLTAFTAPTAFQSGVSHIQSMRSNFDTDVLVSISQGVQDFALDLLQRISVEVEKANKDFMISPFSVWSLLVLLYEGSEGETRNQLKKSLRINVEDEKLRGAYKVWSSFLNITTSTIEVATLQAIYTGKGYPIKNNYRDAIQNYNVQPMEVDFYSPDSVIQINEDTNRTTRGLIPYTILPQDVYGAKMFLLSSLYFKGQWKFPFNKTLTREEPFFSESGEVIGKIPMMVQEANFAYVSNVEGLDGYVLELPYGTQDRLAMIVVLPKRGFKLNDVANNLKALGLRPILQRLAAFRNRASEDNEVEVMMPKFVTATDFTLKGVLIQMGIRDLFDENTANLDRMSSGLFAKLVVHSTKIIVDEQGTTAGAVTEAALANKATPPKFLLNRPFQYMIVEKATGLLLFAGQVRNPKAA
The following text describes a protein:
Function:
Required for the activation of AURKA at the onset of mitosis.
Sequence:
MGDVSELKMQITPETPGRIPVLNPFESPSDYSNLHEQTLASPSIFKSTKLPTPGKFRWSIDQLAIINPVEIDPEEIHRQASYLRLSRIDKDVEDKRQKAIEEFFTKDVIVPSPWTDHDGKQPSELHPSKCLSSHDDSPDGKKPSLPSQKCNAACQTLLSLPVDFNLEAILGDYFREEDFVAHTPGNLSSSSLRRKLFLDGNGSICDPLPSPSPGSPPCSARGSLEGQFSSSPIQNSVKKYSLGSVTTSPSAISSPTFSPIALQGGKTPLSEPRKLTFHSPEASCATASTGIVNPSIRSPYIDGCSPIKNWSPRRLRGGPQCLSSLVRIPFTLEAHSEDEEADVSCTGAAPLSTNACGEPRVVTAMSVTQSHSGIAEKERAVLDDAESERENDTVDMVDPTDTVAESTWIKEPVDDGNSPMTDSASGIAFSIENSHMCMSPLAESSVLPYESSAIQMNSDYNTQTCVSNITDIVGTERYCKENVTHTNVPVPFEVEMKSQVNNVTPGHTAQRCWMKSPRPSQCSRP
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MRGDTQQNRWDKLKNVIVVEENEGNGTSSLPSPGGSESVGSFGSSGTSSETQQHLPNQVDGTFIEGASSSSNEIPPVSGTLEQMRHLVLAAIEATNEQSPHFSGKEGLRNFLLKMPGVFTKGDGPNGKKTEGFLYAYKRGGEVKIVCIFHGYFLTPTEFVKHAGGCAVENPLRLLTVDPN
The following text describes a protein:
Function:
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC.
Sequence:
MAICNFFLQGRCRYGEKCWNEHPRGGGGGGGNRYQSQNRYQEQSRYQEQSRYPEQSRYPEQNRYQEPAGNAKGTWGASSQRYVQPSNFSKSTTWINRDSEKPSAGSFSGFGSRNVKSTAATGLPSTQNRFAALSSQDNSRDGQTDKGNILDDIMKDMEIWESSGQWMFSVYSMLKEKKNISGFTDFSPEELRLEYSVCQAEGNPLKYINAVQQLGSKWKQRILELKNPNPSIKTALLNELNSPSPDVTPGYSGQQNSAFGALSFPTSNTAPTAVTFSFKADTTTAAKPAVPNALAGSDFSAFGNKPTSAPSFGSGVAAAAASFSFAPSTISGFGSTASNSGFGAASNAAGFQGAANIAAAPAFGVASSTAPASGFGGGFGTTVNTGAKTSSVRDLFSAGTAVPVQTTLLFGQATGSLNTTASSTSLAGQPFKASTSATAVSGSFTSDNTSNPLFTPRNELSVEDLAQFEAKQFTLGKTPIKPPSADLLKVT
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKSGGPGFVGIKFCQECNNMLYPKEDKEQRKLLYSCRNCDFQMDADNPCIYVNKIQHEVDELTQIIGDVIADPTLPRTEDHPCQKCEHKEAVFFQSQTRRAEEGMRLYYVCTHPSCMHRWTE
The following text describes a protein:
Function:
Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression (By similarity). The STAT pathway directly participates in immune responses in insects.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Sequence:
METRLHQLPPCILEQFHFLNDLKYPVLIRQHLGNWIKDSLHNAPTYTNNMQSMYELDAAKFFTALVNEVDQVSANLPNKRKCLLCRSAIMLRDQNFQNLTQLYLTLLHQIQPNCEKGCKTEYTIAQTSSDGQQTDVLYGLQQLHVMERNNWKETQQLIQECEQDHVQRLSNQRSHNKRIQCYSLKQRSLVDAFQKTIRKAEEVLNLVYNKYIFEWQKTQMFPEVRSTNAYSLDEIQTWYESLAAIMWNTKDQIHLTMKSQLREHVSQEINSDLWKVMKDVKDFIKLLLHKAFIVENQPPQVMKMNTRFCATVRLLIDNALIMKIGNPKVTVSIISETQAQQIQSTNAAADFSAGEIENNIGNLQYQLSNKFLANFSNMRLKKINRGNRKLNKLVVDEKFALLFQSSFTLEQEELTVTVWTLSLPAVVIVHVNQEQLAWTTIIWDNLCAKADRKLFEVPNLIPWNRLVEAISMTFSARVGRGLTDENMQYMYRKAYRDKLSFSVSNDQMISFAQFCKDTTPECNYTFWEWLYAALKIIRDHLQVLWVDNTIIGFIHKSTAEKYLAKCVPGTFLLRFTDSVLGGISIAWVHESNDGQRQVLHIQPFTAKDLVVRSLANRICDLGELTYLYPTIPKQEAFGRYTAPAIQKPRSKHYISAEMRTVLIFAPSSNQSSSSTPNAEQSPSTSSNDMFSNEYVLTNLDEIYKFEIENDDMLSIQDYWEQQ