lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Hydrolyzes maltose-6'-phosphate and trehalose-6'-phosphate. Is involved in the catabolism of alpha-glycosides accumulated via a phosphoenolpyruvate-dependent maltose phosphotransferase system (PEP-PTS). Is also able to significantly catalyze the hydrolysis of both 6-phospho-alpha- and 6-phospho-beta-glucosides containing activated leaving groups such as p-nitrophenol and does so with retention and inversion, respectively, of the substrate anomeric configuration.
Miscellaneous:
MISCELLANEOUS: Reaction proceeds via a redox-elimination-addition mechanism consistent with an E1cb-type mechanism. This includes redox steps involving NAD(+) and stabilization of intermediates by Mn(2+); MISCELLANEOUS: Because it hydrolyzes 6-phospho-alpha-glucopyranosides without activated leaving groups (such as maltose-6'-phosphate) but not glycosidic linkage of naturally occurring phospho-beta-glucosides such as cellobiose-6'-phosphate nor methyl 6-phospho-beta-D-glucopyranoside, GlvA is certainly more appropriately classified as a 6-phospho-alpha-glucosidase than as a 6-phospho-beta-glucosidase. The ability to hydrolyze beta-glycosidic linkages is exceptional and applies only to activated 6-phospho-beta-D-glucopyranosides.
Sequence:
MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDKERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIPLKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRRLRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLMPKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMVKKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYNTGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVEKLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS
The following text describes a protein:
Function:
Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
Subcellular Localization:
Secreted.
Sequence:
MWLLVVVADCVVLVAAACAVHAQERIKMCGRDLIRLAVSYCGNPRNRRSLPDADLDQHKTLWFSGLSVSPVSAQGATAPPARSSRLPAKKVSDICCEEGCSMKELIQFC
The following text describes a protein:
Function:
Could be involved in detoxification of extraneous host-cell epoxides. Catalyzes the hydrolysis of small aromatic epoxide-containing substrates such as trans-1,3-diphenylpropene oxide, trans and cis-stilbene oxide, and terpenoid epoxide.
Sequence:
MSQVHRILNCRGTRIHAVADSPPDQQGPLVVLLHGFPESWYSWRHQIPALAGAGYRVVAIDQRGYGRSSKYRVQKAYRIKELVGDVVGVLDSYGAEQAFVVGHDWGAPVAWTFAWLHPDRCAGVVGISVPFAGRGVIGLPGSPFGERRPSDYHLELAGPGRVWYQDYFAVQDGIITEIEEDLRGWLLGLTYTVSGEGMMAATKAAVDAGVDLESMDPIDVIRAGPLCMAEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSGFGGPLSFYHNIDNDWHDLADQQGKPLTPPALFIGGQYDVGTIWGAQAIERAHEVMPNYRGTHMIADVGHWIQQEAPEETNRLLLDFLGGLRP
The following text describes a protein:
Function:
TEC1 is involved in the activation of TY1 and TY1-mediated gene expression. It is not involved in mating or sporulation processes.
Miscellaneous:
MISCELLANEOUS: Present with 530 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSLKEDDFGKDNSRNIESYTGRIFDVYIQKDSYSQSALDDMFPEAVVSTAACVKNEAEDNINLIDTHPQFELVNTGLGAKSDDLKSPSAKATFTDKQRKNEVPNISVSNYFPGQSSETSSTTESWTIGCDKWSEKVEEAFLEALRLIMKNGTTKIKIRNANFGRNELISLYIKHKTNEFRTKKQISSHIQVWKKTIQNKIKDSLTLSSKEKELLHLIEHGAEQTTENSNLFYDIFEEIIDSLPSVSDSGSLTPKNLYVSNNSSGLSVHSKLLTPITASNEKKIENFIKTNAASQAKTPLIYAKHIYENIDGYKCVPSKRPLEQLSPTELHQGDRPNKASFSNKKAILESAKKIEIEQRKIINKYQRISRIQEHESNPEFSSNSNSGSEYESEEEVVPRSATVTQLQSRPVPYYKNNGMPYSLSKVRGRPMYPRPAEDAYNANYIQGLPQYQTSYFSQLLLSSPQHYEHSPHQRNFTPSNQSHGNFY
The following text describes a protein:
Function:
Adhesion molecule that accomplishes cell binding by presenting carbohydrate(s) to the lectin domain of L-selectin.
Subcellular Localization:
Cell membrane.
Sequence:
MKFFTVLLFVSLAATSLALLPGSKDELQMKTQPTDAIPAAQSTPTSYTSEESTSSKDLSKEPSIFREELISKDNVVIESTKPENQEAQDGLRSGSSQLEETTRPTTSAATTSEENLTKSSQTVEEELGKIIEGFVTGAEDIISGASRITKS
The following text describes a protein:
Function:
May be involved in assembly and disassembly of the actin cytoskeleton.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKDTHDDELPSYEDVIKEEERLQSQPPRPPRPAANLAQGHQSRPHQRPSTMPATSSSQTYAHSHSYTPTSSQPRPPPRPQQNPSLPWTYPPRFYCSKCGNTGYKLKNGRSCKSCWRRFAPQNNVVSAPTYYTNYTMPVYTNAWQGNRPLYVQPGDPRLGGVLCGECRGSGRTRFLLDEDICPLCHGVGRIITQPQRY
The following text describes a protein:
Function:
Probably involved in the regulation of the fatty acid metabolic process in chloroplasts, especially chloroplastic galactolipids monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG).
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Sequence:
MAPALSTSCSSVMAFSTSNALRYHHPQISLRNSLRAPKSPSFVRLPLGKVLQSRIVIRAASSAAGNPQSDADFNPYEVLGVNPIEGFDKIKQTYGRKLKDAQRSGDEATAALLEKAYDKLMYAQLMNRKKGVTFGSFKVSKDIKYADKQPIIPWGPRFSRSSKNDMLINLAISVVFSAWIAIKRNVEYKPLQFMSFVFVYRIFEKLKSFEAPSSPIYNEEGEESGRGLRMGKRLLRSLSLVFGSILLASLAYTGFLNGIEYMGYSIPMVLYNNQELIVTASSAFMLYVIASFYR
The following text describes a protein:
Function:
Receptor for the Esp1 pheromone. Mediates the response to Esp1 which enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFTLIFLFLFLNIPLLVADFISPRCFWKMKQNEYRDRHHGTGCIFLILAIQQPVKKEYFSHILNIQTHTENHKYALALAFSIYEINRNPDLLPNMSLIFIFSADSCEWESELSLIRFGLQNSDNLPNYLCEELTKCILALTNMNWATTVTLHTILSNFLSDQLLHITYGTFHPALSDHEKFPYLHQMASDHTSLALALVSFIIHFGWNWVGLVISDSDQGIQFLSYLRREMEKYTLCFAFVNMIPLNINLYMSRAEVYYNQIMTSSTNVVIIYGDTDSTLAVSFRMWESLGIQRLWITTSQWDVSPSMKDFTFGNKYGTFAFEQHHSEISGFKHFVQTLNSVKCPDEYLVKLEWMHFNCEVSASKCKTLKNCSSNHSLKWLMVHTFDMAFIEESYYIYNAVYAFAHVLHQFTFQKFDNLPKDNGKEHNYSCKKLYSYLRKNHFINPVGDRVSMNQRDKLQEEYDIVYIWNFPQGLGLRVKIGMFSPYFPNGQQVHLSEDMLKWARGSTQVPTSMCSADCGPGSRKFRMDGMAACCFHCKPCPENEISNETNVDNCVQCPEDQYANTEQNHCIRKAVVFLSYEEPLGVALSLLSLCFSAFTTVVLGIFVKHHNTPIVKANNRTLTYLLLISLIFCFLCPLLFIGHPNSATCILQQLTFGVVFTVSLSTVLAKTITVVLAFKIIASQRMMKYFLISGAINYIIPICILIQVIVCAVWLRASPPSVDIDAHSEHGQIIIVCHKGSVNAFYCVLGYLAILAFGSFTLAFLSRNLPGAFNEAKSITFSMLVFCSVWVTFIPVYHSTKGKVMVAVEIFSTLASSAGMLGCIFVPKCYTILFRQDQNSLEMIRVKSSSNVHVS
The following text describes a protein:
Function:
Desaturase involved in fatty acid biosynthesis. Introduces a double bond at carbon 6 of linoleoyl group (18:2) attached to the sn-1 position of the glycerol moiety of membrane glycerolipids, leading to the formation of gamma-linolenic acid (GLA).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The histidine box domains are involved in binding the catalytic metal ions.
Sequence:
MLTAERIKFTQKRGFRRVLNQRVDAYFAEHGLTQRDNPSMYLKTLIIVLWLFSAWAFVLFAPVIFPVRLLGCMVLAIALAAFSFNVGHDANHNAYSSNPHINRVLGMTYDFVGLSSFLWRYRHNYLHHTYTNILGHDVEIHGDGAVRMSPEQEHVGIYRFQQFYIWGLYLFIPFYWFLYDVYLVLNKGKYHDHKIPPFQPLELASLLGIKLLWLGYVFGLPLALGFSIPEVLIGASVTYMTYGIVVCTIFMLAHVLESTEFLTPDGESGAIDDEWAICQIRTTANFATNNPFWNWFCGGLNHQVTHHLFPNICHIHYPQLENIIKDVCQEFGVEYKVYPTFKAAIASNYRWLEAMGKAS
The following text describes a protein:
Function:
The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSTLEDLDDLEREERDKKKEQGDGGDGKQPGGDGDAEMKDPDAKKKDEDDDLLDEEILNSSTADIIKRRRMLENELRIMKSEYQRLTHEQNTMKEKVKDNQEKIENNRQLPYLVGNVVELLDLDVEAEAAEEGANIDLDATRVGKSAVIKTSTRQTIYLPLIGLVDHEKLKPGDLIGVNKDSYLILDTLPAEYDNRVKAMEVDEKPTEKYTDIGGLDKQIEEIVEAIVWPMKEAERFKKLGIKAPKGALMYGPPGTGKTLLARACAAETNATFLKLAGPQLVQMFIGDGAKLVRDCFALAKEKAPSIIFIDELDAVGTKRFDSEKSGDREVQRTMLELLNQLDGFASDDRIKVLAATNRVDVLDPALLRSGRLDRKIEFPLPNEEARANILQIHSRKMTVEDSVNWAELARSTDEFGGAQLKAVCVEAGMIALRKGHSKIGHENYVDAIAEVQAKKKDTNMGIYV
The following text describes a protein:
Function:
Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (By similarity). Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MDDQDPGGISPLQQMVASGAGAVVTSLFMTPLDVVKVRLQSQRPSATSELTTPSRFWSLSYTKSSSALQSPGKCLLYCNGVLEPLYLCPNGTRCATWFQDPTRFTGTLDAFVKIVRHEGTRTLWSGLPATLVMTVPATAIYFTAYDQLKAFLCGQSLTSDLYAPMVAGALARMGTVTVVSPLELVRTKLQAQHVSYRELASSVQAAVTQGGWRSLWLGWGPTALRDVPFSALYWFNYELVKSWLSGLRPKDQTSVGISFVAGGISGMVAATLTLPFDVVKTQRQMSLGAVEAVRVKPPRVDSTWLLLRRIRAESGTRGLFAGFLPRIIKAAPSCAIMISTYEFGKSFFQRLNQEQPLGR
The following text describes a protein:
Function:
Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. Probably acts as a ligand for lad-2 to regulate axon guidance of several neurons including SDQL, SDQR, SMD and PLN neurons during neurogenesis.
Miscellaneous:
MISCELLANEOUS: In contrast to other ephrins, does not seem to signal through the vab-1 receptor.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKRPLDFLLAICLILLRSSTFADEHTVHWNSTNSMFRNRHPSIEVRLGDVVRFVCPDNEGRKNGEYLTVYEVSEFAMGECALESNSREVIKCGVDTNTEKIIRTHQLPIGESREPPKNVAQFIRSVNPIPNGKEYQPGQTYYYITTSSGKPGGIGQQMYGLCVSKNMRLSMKVLSSQPTPSPSSKPARSRTDARRQEDFITKSSAELMGGQEDEDSENDNAHLLPRDLEIATNPKFRRPSQFDQAAASAGVLDGQFLKVVQMAKEGKTGTFENDREVQKSAEKDAWDPINRHYVADLMNSAYKNANDRVVYQREPDFLIHEEDISTNSLGYSSSSSSSLPTFLIVFLIAVNLLF
The following text describes a protein:
Function:
Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.
Sequence:
MAAALGRLWERAAGGRLFLLQQVAVHPFQLRSASVLTYCRELPFNHLSLKPTGTIPSFPSPVPSWSHQQIRTKARGNEYQPNNRKRKRTHGWIKRISTPAGIEADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVEIEGENSAPPRKIARTDSQDMNEDT
The following text describes a protein:
Function:
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPESPFGADVGKQPGLEIWRIENFAPVAYDKKSYGKFYSGDSYIVLNTRLSGDKLKWDIHFWLGKDTSQDESGAAAIFAVELDDYLGGVPVQHREVQEYESSMFLANFPSGVRYLDGGVASGFKHVDPDQVEKKLLQVKGKRNVRVRQVPLDVSSMNKGDCFVLDAGKVIFVYMGNSSKKVERLKAIQAANQVRDQDHAGKARIVILDEFSNGGDVTTFFNELGSGSPGEVPEASPEDDDVSFEKQQQSSVILFRVSDASGQLVIEEVGQKPLQQSMLKREDCFILDTAGSGLFVWIGRGCTKAEKLEAMNVAQKFLTEKGYPLWTKVNRVVDGGEPTIFKQYFASWKEETGGKEHAPVPMKNGRIAGKQNMITNTKFNVSSLHKDKLRLLLKQGGAAPGFSPDDGNGEKEIYRVENFELAPVDPAAYGMFFGGDSYVIKYTYNISGRNRYIIYFWQGNDSSQDEKAASAIHAMRLDNEVAGKAVQVRLTQGNEPRHFIKMFKGQMIVFTGGHASGFRNIHDYDSYDVDGTRLFHVRGYAADDMRAVQVAETASSLNSDDVFVLETPSKTYLWNGVASSDDEKSLGVEIANLVSPGREMVPINECEEPQEFWDALGGKGPYTTVQPDPPPVLKARLFHCILNIFGRLRVEEMKPFKQEDLVDDDVMVLDSGHEIYVWIGLHSTDKEREAGFKMAQEYLVTEPSQRSVDSTLIFMIHQRQEPESFTDVFPTWNRNMWKV
The following text describes a protein:
Function:
The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2. In complex with PAF1, required for normal CLN1 and CLN2 G1 cyclin expression in late G1. Also has a role in chromosome segregation where it appears to be involved in microtubule placement.
Miscellaneous:
MISCELLANEOUS: Present with 12900 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MTNAMKVEGYPSMEWPTSLDIPLKASEELVGIDLETDLPDDPTDLKTLLVEENSEKEHWLTIALAYCNHGKTNEGIKLIEMALDVFQNSERASLHTFLTWAHLNLAKGQSLSVETKEHELTQAELNLKDAIGFDPTWIGNMLATVELYYQRGHYDKALETSDLFVKSIHAEDHRSGRQSKPNCLFLLLRAKLLYQKKNYMASLKIFQELLVINPVLQPDPRIGIGLCFWQLKDSKMAIKSWQRALQLNPKNTSASILVLLGEFRESFTNSTNDKTFKEAFTKALSDLNNIFSENQHNPVLLTLLQTYYYFKGDYQTVLDIYHHRILKMSPMIAKIVLSESSFWCGRAHYALGDYRKSFIMFQESLKKNEDNLLAKLGLGQTQIKNNLLEESIITFENLYKTNESLQELNYILGMLYAGKAFDAKTAKNTSAKEQSNLNEKALKYLERYLKLTLATKNQLVISRAYLVISQLYELQNQYKTSLDYLSKALEEMEFIKKEIPLEVLNNLACYHFINGDFIKADDLFKQAKAKVSDKDESVNITLEYNIARTNEKNDCEKSESIYSQVTSLHPAYIAARIRNLYLKFAQSKIEDSDMSTEMNKLLDLNKSDLEIRSFYGWYLKNSKERKNNEKSTTHNKETLVKYNSHDAYALISLANLYVTIARDGKKSRNPKEQEKSKHSYLKAIQLYQKVLQVDPFNIFAAQGLAIIFAESKRLGPALEILRKVRDSLDNEDVQLNLAHCYLEMREYGKAIENYELVLKKFDNEKTRPHILNLLGRAWYARAIKERSVNFYQKALENAKTALDLFVKESSKSKFIHSVKFNIALLHFQIAETLRRSNPKFRTVQQIKDSLEGLKEGLELFRELNDLKEFNMIPKEELEQRIQLGETTMKSALERSLNEQEEFEKEQSAKIDEARKILEENELKEQGWMKQEEEARRLKLEKQAEEYRKLQDEAQKLIQEREAMAISEHNVKDDSDLSDKDNEYDEEKPRQKRKRSTKTKNSGESKRRKAAKKTLSDSDEDDDDVVKKPSHNKGKKSQLSNEFIEDSDEEEAQMSGSEQNKNDDNDENNDNDDNDGLF
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MKRYMFGTLPRVQPKRCFQTAIGKESPKGNSEKDQLFENPFFQQLPSNVAAVYLNPVKFNPSENDVLCASLKIKSFETPKLDTFTDFICRTAYYMKIPIKGPRPLPNKVESWTLLRSPFIHKSSQENFERITHSRLIQLYSVNPVTLETFFSYLRKCNMWDLKLQAKAYEYESIDDALKNFESQSKSTDNFKELLNGPSKKDIITQNAEKLLRNDPIYKDLLKNSSRK
The following text describes a protein:
Function:
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Subcellular Localization:
Cytoplasm.
Sequence:
MRALKDEWNVIGTGRSDETIERVRRVGAIATKDNSMACRIADVVILSVKPSHLRDLLPLSRHLEGKLVISVLAGVRTSMLESEFPKARIVRAMPNINAIIGASVTAISAGRSARESDIEVAERIFRKLGDVFRVPEEYMDPITALIGSGPALISEIIDAMLLGAVAAGMPRELAYEMLLKLMEGTVRALEETSMHPAQLRDLVTTPGGTTIAGISVMEEMRVKSGIIYAIKGASDRAKELGMHMESLVLAQT
The following text describes a protein:
Function:
Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.
Subcellular Localization:
Nucleus.
Domain:
Mutagenesis of amino acids 147 to 164 and 155 to 164 lead to a major cytoplasmic localization, with only minor localization in the nucleus.
Sequence:
MARSLVHDTVFYCLSVYQVKISPTPQLGAASSAEGHVGQGAPGLMGNMNPEGGVNHENGMNRDGGMIPEGGGGNQEPRQQPQPPPEEPAQAAMEGPQPENMQPRTRRTKFTLLQVEELESVFRHTQYPDVPTRRELAENLGVTEDKVRVWFKNKRARCRRHQRELMLANELRADPDDCVYIVVD
The following text describes a protein:
Function:
Involved in pre-mRNA splicing by stabilizing the NTC (or PRP19-associated complex). As a component of the NTC complex, associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation.
Miscellaneous:
MISCELLANEOUS: Present with 721 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDGLSFVDKGKIPDGYKNEIDQLVKKEFANIKREPVHPEIRGILAKRKGADNSVSTLTNALYTEYLKQRNNKKRRTPDFNDDDDTLFLEEYRRKYPRIDTSRYIPNESSEVSLLGIVDSYLKHQEIVLDTLLPQTVSNQWRINNDYIRQTCTIVEEMNIQQRKQINDLEIYRKRL
The following text describes a protein:
Function:
Galactose-specific adhesion protein essential for non-sexual flocculation and filamentous growth. Required for adhesion and filamentous growth through recognition of galactose residues on cell surface glycoconjugates. Induces flocculation when overexpressed.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MSVRRFLSTSARALLFTAALLPSLTSGLPSGNVRILQKGMEPEDYLSSASQNEVPHDISLPKTELADPNFLVDDMPTLLGRDAAVDPSMFTSTFTVKNGNDANYITASPVSNDASMTAISTFTSGKEASYAIQASPSTFLPDSTTTSGSQVSNAVEASSTFVADTTSTSCNPATVLIVTTSGSTSTSCPPPTTILIVTVPTTTTTTTVGYPGSVTTTLTGTPSNGTVIDTVEVPTTTNYGYTTITTGYTGSTTLTTTVPHSGNETGPTTVYVETPYPTTVTTTTTVGYPGSVTTTLTGAPSNGTVIDTVEVPTTTNYGYTTVTTGYTGSTTLTTTVPHSGNETGPTTVYVETPYPTTVTTTTTVGYPGSVTTTLTGAPSNGTVIDTVEVPTTTNYGYTTVTTGYTGSTTLTTTVPHSGNETGPTTVYVETPYPTTVTTTTTVGYPGSVTTTLTGAPSNGTVIDTVEIPTTTNYGYTTITTGYTGSTTLTTTVPHSGNETGPTTVYVETPYPTTVTTTTTVGYPGSVTTTLTGAPSNGTVIDTVEVPTTTNYGYTTITTGYTGSTTLTTTVPHSGNETGPTTVYVETPYPTTVTTTTTVGYPGSVTTTLTGAPSNGTVIDTVEVPTTTNYGYTTVTTGYTGSTTLTTTVPHSGNETGPTTVYVETPYPTTVTTTTTVGYSGSVTTTLTGSGSNSIVTETVDVPTTTSVNYGYTTITTGWTGSTTLTSIVTHSGSETGPTTVYIETPSVSATTTTTTIGYSGSLTTTLTGSSGPVVTNTVEIPYGNSSYIIPTTIVTGTVTTVTTGYTGTETSTVTVIPTGTTGTTTVVIQTPTTVTATETDIVTVTTGYTGTETSTVTVTPTGTSTGTTTVVIQTPTTVTATETDIVTVTTGYTGTETSTVTVTPTGTSTGTTTVVIQTPTTVTATETDIVTVTTGYTGTETSTVTVTPTGTSTGTTTVVIQTPTTVTATETDIVTVTTGYTGTETSTVTVTPTGTSTGTTTVVIQTPTTVTATETDIVTVTTGYTGTETSTVTVTPTGTSTGTTTVVIQTPTTVTATETDIVTVTTGYTGTETSTVTVTPTGTSTGTTTVVIQTPTTVTATETDIVTVTTGYTGTETSTVTVTPTGTATGTTTVVINTPTTTGSEVLPTTGATGTAGTETQLTTATEVQPTTGATGTAGTETQVTTGTETQATTATETQATTATEVQTTTGATGTAGTETQATTATEVQPTTGATGTAGTETQVTTATEVQPTTGATGTAGTETQVTTGTETQATTATETQATTATEVQTTTGATGTAGTETQATTATEVQPTTGATGTAGTETQVTTATEVQPTTGATGTAGTETQVTTGTETQATTATETQATTATEVQTTTGATGTAGTETQVTTATEVQPTTAVTETSSSGYYTTIVSSTVVSTVVPGSTVYPVTHVTTTTGVSGESSAFTYTTSSTQYEPSTVVTTSYYTTSVYTSAPATETVSSTEAPESSTVTSNPIYQGSGTSTWSTVRQWNGSATYNYTYYTTGGFTGGNNTNVTGLYPSSAGANKPIAYLTFVSLFVYIVTLI
The following text describes a protein:
Function:
Hydrolase highly specific for thiamine triphosphate (ThTP).
Subcellular Localization:
Cytoplasm.
Sequence:
MSSIATSVLEIEKKFQIPVRFEETLLSNGGKLTERREFQDVYYDLPDNSLTLKGLWLRKRNTKWELKHLNARCDPTISITDKYHETSDETKIMTELSKHVPMATSLDELVSKHCREFASFTTQRTSYQLPNDVRVDLDVASFGYSVGEIEIVIDDETGVSEAEQRLEGLAEKLGINWQKKFPGKVEEFLRLNDPVHLEKLMEKHLL
The following text describes a protein:
Function:
Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4; Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (By similarity).
Miscellaneous:
MISCELLANEOUS: Histone H3 acetylation of 'Lys-9' decreases the binding of the substrate, while hyperacetylation of 'Lys-9', 'Lys-14' and 'Lys-18', phosphorylation of 'Thr3' or 'Ser-10', and methylation of 'Arg-2' or 'Arg-8' abolishes its binding. Methylation of 'Lys-9' and 'Arg-17' are the only two epigenetic modifications that have no significant effect on catalysis.
Subcellular Localization:
Nucleus. Chromosome. Note=Found in actively RNAPolII-transcribed gene bodies.
Sequence:
MAASRGRSKKRSNLELSPDNLPLRSSGRQAKKKAVEIPDEDEDGSSEKKYRKCEKAGCTAAYPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYDKYSAWKRVWTSNGKTEPSPKAFMADQQLPYWVQCTKPECGKWRQLTKEIQLTPHMARTYRCGMKPNTITKPDTPDHCSFPEDLRVLEVSNHWWYPMLIQPPLLKDSVAAPLLSAYYPDCVGMSPSCTSTHRATVTAATTTTGSASPGEMEPSKAAPSSLVLGMNRYFQPFYQPNECGKALCVRPDVMELDELYEFPEYSRDPTMYLALRNLILALWYTNCKEALTPQKCIPHIIVRGLVRIRCVQEVERILYFMTRKGLINTGVLTVAAGQHLLPKHYHNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDKSFKGVVVGRGPQIVNGCINNPVALMCEQLGISMRKLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRKDKTLLQDVPLGEKIEEIYRAFVKESGIQFSELEGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGADFFGHVPPSASQRGLFAVFYDMDSQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF
The following text describes a protein:
Function:
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
Sequence:
LVCEEVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKFAQTSEEELFGNNEESPAFVEFLEFLGEKIDLHDFKGFRGGLDVTHGQTGTESVYVNFHNKEIMFHVSTKLPYTEGDSQQLQRKRHIGNDIVAIVFQEENTPFVPDMIASNFLHAYVVVQVENACTENVLYKVSVTARDDVPFFGPALPDPAVFKKSSEFHEFLLTKLINAEYSCYKAEKFAKLEERTRSALLETLYEELHMNSQSMMGLGGDDDKLENGGGGGGFFESFKVEYTYNEMAFANVN
The following text describes a protein:
Function:
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
AFPSWHFHDFMFIFYIDAYTINCTGFDLYGVDPNAFQSVFDRKAFRPVINFRVPTLVNISFTLSAILDVDAQIQLMTSFLWVNMVWDNPFISWNPEECGGLTEISVAAKNLWLPDLFIIEFMDVDTTPTSLYAYVHSSGRINYDKPMKVTSICNLDIFYFPFDQQNCTLTFSSFLYTVDHLLLGMEKEVWEITDNSRDIIRTQGEWELLGINKATPKLIMGSSLYDQIMFHVTIRRRPRLYVINLLLPSGFLIAIDALSFFLPVESGNRAPFKMTLLLGYTVFLLMMNDLLPASGTPLISVYFALCLSLMVVSLLEAIFLTYLLNLVTTQPPPMPPWLHSLLLHYLRATDRCNKRSQKEPRGSGPNLIHLPGLMEPVVMATWVPGSSEAKLNGDPGSTRAPLEQEAQGRLTANMWGKFIVILDKLLFWLYLLFMVSSLTTVIILWNT
The following text describes a protein:
Function:
Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B. EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming. EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (By similarity).
Subcellular Localization:
Cytoplasm, Stress granule. Cytoplasm, cytosol. Mitochondrion. Note=Colocalizes with NANOS3 in the stress granules (By similarity). Relocalizes to the surface of mitochondria in response to mitochondrial damage and phosphorylation by EIF2AK1/HRI (By similarity).
Sequence:
PGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGRILLSELSR