lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Subcellular Localization:
Secreted.
Sequence:
MKKGNLFVASMFLLQSCESLLPIASFENGEDHGDDTGMALYPLKISHSSCALKADGGPCRAMLRRYFFNISSRKCEEFEYGGCGGNENKFLMLEDCQKKCISEYSPRTKGLKEKPEFCYLEEDVGICRGLISRYFYNNQSKQCEEFKYGGCLGNENNFESLEECKRTCGDGLDSLQVDKEEIQPDIIVKPSQLPSDFEFSSPSWCRTPAERGLCRANEKRFFYNAVIGRCHPFNYSGCGGNENNFTTRKACLQNCKKGFNRKVKGGLIKTKRKRKKLPVKITYEKILIGKI
The following text describes a protein:
Function:
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MAAATSSAVLNGFGSHFLCGGKRSHALLAASIGGKVGASVSPKRVIVAVAAAPKKSWIPAVKGGGSFIDPEWLDGSLPGDYGFDPLGLGKDPAFLKWYREAELIHGRWAMAAVVGIFIGQAWSGVPWFEAGADPNAIAPFSFGSLLGTQLLLMGWVESKRWVDFFNPDSQSVEWATPWSKTAENFGNSTGEQGYPGGKFFDPLGFAGAIKDGVYIPDADKLERLKLAEIKHARIAMLAMLIFYFEAGQGKTPLGALGL
The following text describes a protein:
Function:
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLRLFSLALITCLIYYSKNQGPSALVAAVGFGIAGYLATDMLIPRVGKSFIKIGLFGKDLSKPGRPVLPETIGAIPAAVYLFVMFIYIPFIFYKYMVITTSGGGHRDVSVVEDNGMNSNIFPHDKLSEYLSAILCLESTVLLGIADDLFDLRWRHKFFLPAIAAIPLLMVYYVDFGVTHVLIPGFMERWLKKTSVDLGLWYYVYMASMAIFCPNSINILAGVNGLEVGQCIVLAILALLNDLLYFSMGPLATRDSHRFSAVLIIPFLGVSLALWKWNRWPATVFVGDTYCYFAGMVFAVVGILGHFSKTMLLLFIPQIVNFIYSCPQLFKLVPCPRHRLPKFNEKDGLMYPSRANLKEEPPKSIFKPILKLLYCLHLIDLEFDENNEIISTSNMTLINLTLVWFGPMREDKLCNTILKLQFCIGILALLGRHAIGAIIFGHDNLWTVR
The following text describes a protein:
Function:
Inactive phosphatase which acts redundantly with egg-5 in the oocyte-to-zygote transition. Required for the polarization of cortical actin cytoskeleton rearrangement in the oocyte before and after fertilization. Together with egg-5, required for the cortical localization of kinase mbk-2 and for the inhibition of mbk-2 kinase activity in maturing oocyte until the end of meiosis I. Also required for kinase mbk-2, pseudophosphatase egg-3 and chitin synthase chs-1 localization to cytoplasmic foci after fertilization.
Subcellular Localization:
Cytoplasm, cell cortex. Note=Co-localizes with egg-3 to the cell cortex in developing oocytes and in newly fertilized embryos; cortical localization requires egg-3 and chitin synthase chs-1. At the beginning of meiosis anaphase I, egg-4 moves away from the cell cortex and is likely degraded.
Sequence:
MALNSEVMFREQINAMRSQAGRKRATSLQSFCSGNTDDSSADSTDNMDMMVDYPQQKGVSCMRARFNSESTLSKSFRKKVKKLAQKDRRSKERLNGNSEEDAIEVPRGAPSTYAAPSKLRKSKALDCLVSEKPKDEGRREDSGHGADIEMAKGHFNNVRMKVFAARTAMQVEPALVMKTRKALEMKNAVLENHQSPGAFSLHAAYKIAASAESRVGSITPCNKKVTKEAMANLIRSSYDDTEITQELLFSSKFDTKWKGRYTDIYMRRDENGKKPKRPVNGQGWVMPLKSICEKFGINSTFFTNHRIDLKSARDQVLLMRLLSHDQTSTWISDIHPEAVKNETMAEYLLRELDASTMQKRVQAFKANVLADRDRVRVAGQFYNNIRIGKRMFGAARKAKYLSTIIGGMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPERCEYYWPKSPSDPAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICSLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRDVIGSAKELDVDYERWLQERSERMFLDDLAAPIPGYRLLSPRADPDIVRMVGRPERPNYRREAPDCVGEMPNKVATVDGILSPAKSVFEF
The following text describes a protein:
Function:
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGRPMQAARCPTDELSLTNCAVVNDTDFPSGQHVVVKTSPNHKYIFTLRTHPSVVPGNIAFSLPQRKWAGLSIGQEIDVSLYTFDKSKQCIATMTIEIDFLQKKNIDSNPYDTDKMAAEFIQQFNSQAFSVGQQLVFSFNDKLFGLLVKSMEGMDPSILKGESGASKKQKIEVGLVFGNSQVAFEKAENSSLNLIGKSKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLMARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGVHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIVLRRKFECKENRLGLIEGIVLLSYSEKSKAVEIHVQKLETQFQICSFCLPDEKGRFQILHIHTVRMREHQLLAEDVDIAELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLRVTRGDFFASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLMEALELLGNFKDKERSTIAQNVKGKSVWIGIKKLLMLIEMSLQMDPEYRVKKFLALLREEGTVP
The following text describes a protein:
Function:
Actin-bundling protein.
Subcellular Localization:
Cytoplasm.
Sequence:
MEIVPYPAVLRAACFQKTGNSLGAEPEGSQREMAGKISKDELEELREAFEKVDLNGNGYICDYELHELFKEANLPLPGYKVREIIQRLMEEGDKDKDNRISFDEFVSIFQELKSSDIAKSFRKAINRKEGILAIGGTSELSSEGTQHSFSEEERFAFVNWVNKALENDPDCKHVVPMDPNSNSLFKAVGDGIVLCKMINLSVPDTIDERTINKKKLTPFTTQENLNLALNSASAIGCHVVNIGAQDLREGKPHLVLGLLWQIIKIGLFADIELSKNEALAALLRDGETLEDLMKLSPEELLLRWANFHLENAGWNKINNFSSDIKDSRAYFHLLNQIAPKGTKEGETRIDINMSGFNEKDDLKRAELMLQEAEKLGCRQFVTPSDVVSGNPKLNLAFVANLFNKYPALIKPENQDIDWGLLEGETREERTFRNWMNSLGVNPHVNHLFADLQDALVILQLYENIKVRVDWNRVNKPPYPKIGTNMKKLENCNYAVDLGKKDAKFSLVGIGGQDLNDGNPTLTLAVVWQLMRRYTLNVLEHLGDGEKATDEIIVKWVNKALSEAGKKTKIQSFKDKEISSSLPVLDLIDAIQPSSINYDLVKTGSLSEEDKLENAKYAISMARKIGARVYALPEDLVEVKPKMVMTVFACLMGRGMKKV
The following text describes a protein:
Function:
May be involved in DNA damage response. Appears not to be involved in DNA replication in trophozoites.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm. Note=Unlike PCNA1, does not localize to nuclear foci. Enriched in the nucleus in response to DNA damage.
Sequence:
MFECRIDGQFFKKLFETLKDICTEVNLECDENGIKMQSMDCSHVSLVDLNIVSDFFQHYRCDKNCVLGISINFMLKILSVIKEKSTVFLFKEDNENDAVLNIGIIDEEEQSSADDSLEIQVKLINAQKEHLEIPQSEYHCQCTMKSKKFQEFTKYLNSIGDNVSISMKKDAMILSTTGSDIKVTKQFTNDMTDISITCTKSVSQEFATRYLVMFSRASSLSDEVLISLSPHIPISIKFNFKQQLTDLQDPSHLTFFLAPKIGDY
The following text describes a protein:
Function:
Carbohydrate binding protein that binds chitin and cellulose. Lacks enzymatic activity and does not hydrolyze chitin and cellulose. May interact with mycobacterial biofilms, which are rich in cellulose, and play a role in biofilm formation. Could also act as an adhesin, improving the initial attachment to host cells and aiding M.tuberculosis during the initial stages of infection. Recombinant M.smegmatis harboring Rv1987 shows enhanced cytoadhesion to human lung epithelial cell line A549; When expressed in M.smegmatis as a model mycobacterium, Rv1987 acts as a virulence factor that modulates host immune responses and contributes to host immune evasion. Can attenuate the inflammatory response induced by mycobacteria and alter lung microbiota composition, leading to the dysbiosis of lung microbiota, which in turn facilitates mycobacterial survival in the host. Infection of murine T-cells with a recombinant M.smegmatis strain overexpressing Rv1987 promotes Th2-biased cytokine responses in mice with lower production of the Th1-type cytokine interferon gamma (IFN-gamma) and higher production of the Th2-type cytokine interleukin-4 (IL-4), which enhances M.smegmatis survival in mouse lungs. Infection of murine macrophages with the M.smegmatis strain overexpressing Rv1987 induces the M2 polarization of alveolar macrophages in mouse lung through activating the PI3K/Akt1/mTOR signaling pathway. The bactericidal ability of these M2 polarized macrophages decreases remarkably, which results in the increased survival of bacteria in macrophages.
Miscellaneous:
MISCELLANEOUS: Identified as a drug target. Also identified as a potential subunit vaccine candidate through a systemic immunoinformatics approach. Rv1987 exhibits a strong potential immunogenic response useful for the development of a tuberculosis vaccine that would be used in tuberculosis models to generate humoral and cellular immunities.
Subcellular Localization:
Secreted. Secreted, cell wall. Cell membrane.
Sequence:
MAGLNIYVRRWRTALHATVSALIVAILGLAITPVASAATARATLSVTSTWQTGFIARFTITNSSTAPLTDWKLEFDLPAGESVLHTWNSTVARSGTHYVLSPANWNRIIAPGGSATGGLRGGLTGSYSPPSSCLLNGQYPCT
The following text describes a protein:
Function:
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MLCCITCVNVNDFWKKIAEKPSWVRHEGMQIFSIDVQPGGLRFATGGGDHKVRIWNMKSVCGESGDIGNDESSQRLLATLRDRFGSINCVRWAKHGRYRKSGLGTTKFGSGEPPNIEYWKVALTLRGHVAYLVGLNWSPDDSTLASGSLDNTIHIWNMSNGICTAVLRGHTSLVKGVAWDPIGSFIASQFDNKTLGSTFFRRLGWSPCGHFVTTTHGFQKPRHSAPVLERGEWSATLDFLGHNAPIIVVKFNNSMFRRNFYNAQEVKSVDVGWANGASKTGSKEPQPYNVIAIGSQDRTITVWTTASPCPLFVAKHFFTKSPNGYSLFACSLDESVATFHFEVKELGRRLSDAELDELKRNRYGDLLPSKKVVSDVRQNQTVEKGYDDVHIASKKAEPQVDDCKKSGGTIGDGLSNATASARISNPVKQREYRRPDGRKRIIPEAVGVPVQQENISCVVQSQAHDFPLILITEWVTFELKSDLKERSGVTARAIVLESLGIEKVPASSGIDGNINVEQLGNSTTTGSLSASCATLSIRVFDYKSGADTSPICLEARLREHAVNDIIGIGNTSMMRETEIACTRGPQTLWSDRISRKVTVLARNANFGAVGCEDGCFQKESPSFALTNSVQVVSVHSLCTRTIKVIFARLSKSGSPLVVLATRQAFLFDMSLKCWLRVADDCFPASNFASSWSMGSIQSGELAALQVDVRKYLARKPGWTRLTDDGVQTRAHLEAQLASALALESSKEYRQCLLSYVHFLARLFRDNYTDFSLRSQTITLRPYLIQKLRLHSLFFNLLYYSNTLTRLVHGSVHHRKLNLTELENSSLQEKQMNLDYENSESFLGPPTGMAGEASSDSKSAWDPFVLGMRKHKLLIEDILPSMASNRKVHRLLNEFMDLVSEYEIAPVTEDIAANDQQKNQKYPEDAALNSKDNPQVAKVQTKITPALADEVTEHALVTYHANQDTQTNEGGS
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MSPRDVSALLFLCWCVMVSAKSVETSAVRTKRTTASCENVRKFFQFRNITMSPEKHRGSVCGGECCSDADEDLLRKQGQKDFAGLLRHNSRSLQGRLSFTAATLQNHISELTRQSENKTMQLFAQVYKSMAGLCHNQIEKLYSDIRKSVLNTSQVDLPSIDLQESVSQFFRDFFPFVYRHILHLNGSKDFTPDYKACLRKTTETIAPFGDIPDRLGRSLAETLNATRMLLQAFEIGIEVLNSTDRLLLDETGKSNTECHEALLKMHYCPKCLGMAKAKPCSGYCLNVLRGCLTKYVVELDSPWNGYVEGIESLIRSMKTGESADAVIRSVDLKISEAFMRAMQKGKDIDSKVQRNCGSASFFEAVRVESSTPLPATVKPRFSGVDANMQLSDFVNNLGKTRGFYATLANTLCKDESFAETKDQRCWNGERIAEYTKMVVDVTLNTQRYNPEVKPPSFHESDRRVADLVDKLRQVHHMAMKSIGTPGPEVDYMQRDGVEGSGSGNGPDFEDNDDDSYSRGSGSGHGPIEGKPPIMGLFGLLIGALQERTMGRAPGARTRSSRRRRRGRRAARSSRPRCSYRPSPS
The following text describes a protein:
Function:
Cargo-specific adapter that is involved in nuclear migration during development and thereafter. Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it interacts with unc-84 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules. Within the complex, connects the nuclear envelope to the microtubule cytoskeleton through the kinesin-1 light chain protein klc-2 (most likely within the Kinesin 1 motor complex) to regulate nuclear migrations. Moreover, within the complex, also recruits the large microtubule-associated bicd-1-dlc-1-egal-1 and lis-1-nud-2 complexes to the nuclear envelope to regulate both the bidirectional migration of nuclei and the extent of nuclear migrations. Not required for centrosome attachment to the nucleus.
Subcellular Localization:
Nucleus membrane; Single-pass type IV membrane protein. Nucleus outer membrane; Single-pass type IV membrane protein. Note=The transmembrane domain associates with the nuclear envelope. Co-localizes with unc-84 and lmn-1 at the nuclear envelope.
Domain:
The KASH domain, which contains a transmembrane domain, mediates nuclear envelope targeting.
Sequence:
MDVMDSFSEVEMPNDISSEDHLLKVIESSAEEVDIFLENCSSLYNLILDSLHNLTSKTISCECLDEMTSTLEKSAKKILAERPEAENSVLLRLNTICCAMDQLRVQHNSRMMSGADSDTASSARSSTSSSTGEMRLWLHEVERRLEINEKRIRVEPNLQLLLSDQQALQLEIQHEGQLLVNRLNKQIKDDHDSDSSEEEKRKTCVDAIRKRWHTIYLNSLSLVCRIEELINHQQASEDSESDPDLVGPPIKRARIRTVGHLTASDTEESEADEEDRHSQTETVVTEDDNVLPFAENEYESIMDGRVTVDSCTSSSEDQMVEQSTNKKWESVLQDVGYSSGENSIHEALNTCADHLVPETSDMRRKRIECSPVKAFYRTVQLEDMSDLEVTKAINHDVEEEPNLSDSMYVNHDSTFLATQNLPEYDEVMALMDDDDLPMDMSMTESFNTKWREIHGQKKPLRRASRPSREQMNLIAKSSCDASSEDSSEGENQTNLEDDPEMMSVSFNSAQFDTSSPLKRQRSARGLKNASFLYDSLEMDGSFCSTRSEMLPPCKTRSLARRKLRVRRMPRSMSDGEQLGVVSSKPEGMMTPMIRVSPPSTPVRRLLRKLDEQIRNRDSDTAPEHSDAAQAYEWDEYNPPQKDDSISDRHIQTMTDISDQLMNIDDDFAEHFGTSSAIRLIEESKSHLRVVLKALEESDSNIPQLSNFELIARSNLRQVDEALKIQSGNQPSFLETSTLQDLRSEWANLYESIRSPFARIMHQVKKFAATLQEVSSMASLGDVDIRSKEDVAKTLDAVTAIERRLSSERQELRDLLASSSFRDVAKDLSCEFESVSEGYDDAVDKIGKMAHSLSQVKGEWDAWNSRQNDIRNAMVRIESHLKEGQMDNKMIADEMELCQERMNSLETMCNYLTASLGSIQNESNSKNLPDFKAELSIYSNALARLKDRFNDMIRVPTPPTVQFHPPEPLPSLARSMTTQTAEMESETENEPLTIAEAISSSRLIKFTFALSLLAALAAIFYYHVFGKPFGPHVTYVNGPPPV
The following text describes a protein:
Function:
May act as a GTPase-activating protein for Rab family protein(s).
Subcellular Localization:
Cytoplasm.
Sequence:
MDYKQRIEKFKDILNSEEPISLPGLCSLCIQGIPDEYSLRAKAWMLMLEFLPTDRSNWQSVLEKHRKTYTSFVQELLIDPWRKLTLHEESGENSDHPLNTSDDSKWKEYFDDNQILEQIDKDIRRTLPDLSFFQGKSEINKKPSVNNVSENISVNTEDDKVEEVGQKLNYTKITSIDQSQETPVHLSTIDFSKFQEECHLVLQGRIYRLENESTSSSTTALSTPRQSMDSKRTINAEAIAGENKLGLHREAAERILFIYAKLNPGIGYVQGMNEILAPLYYVLATDPTYENYYLCECDAFFLFTQMMVQVRDLYEKTLDHDSDHGIHFLMSKFTERLKKYDYELWENLEEKQIHPTYYSFRWFTCLLSQEFPLPDVIRLWDSIIADQMKARLFGKNDDGFNGAYDFLMDFCCSILIELRESILERNFADSIKLLQAHFNVDMPKLLNLTFELQHLRKTSKNDEDMSYVRKNSYNTNALANSLKNRVLSTYNTVKANVPQSSSSYTDNNKQKEPLEEKRSFFPSFRSSLDGVSPTQGRKSGEENIRTIFAKPTAHIGENGWSNLKVKGSSIFQRFGNFVGDTMRYITEEEESSEEEDLTTSRRKIGITSKRKVSVKRNVI
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDHRKVHVSFDEVAVYFSEEEWKHLEVWQKELYNEVMQDIMKTLWSLEDNLVRGDGKQNPAGYALMPQWSNDKGAPVRTNHSETAKLKHDQGKNTHMLGNLNHRFQEREGLSHPDQVTGHKDNLEHTLLQDIHKCTIDILYQCIDCKEIFSSQSLFDAHMIRHTAQAASSYNNSPWNYLGASCLTAVPSREMYESHSSLVGVSACAAEENWLRCLYCTKQFSDLSILMEHERSHRERKAFICSECGKSFHRLSILKVHQRIHTGERPYACPDCGKRFSQRFNVVIHQRIHTGERPYNCPKCNKSFRYQTTLLKHEKAKCVGTIPTTYPLQKAKNFQTLLLKNALPLKVTQPTTIQPPLTSEPLSSSSLLFVSPKPIIATPFTLVSKNRSIGGLAPPLQNISRHKNHINGTSIIPTKDHHPIEKQFRCGHCNKHFVHWKQLKEHQKSHVDTQNMCTVCNKSFCRRSTLLIHQRTHTGEKPYTCNECGKKFSQRFNLVIHQRIHSDEKPYQCHKCGKDYRYRTALLRHQRNPPCAPKQSFSKSTLTSHGELPSPSNRALQGLANNKQQPITKKTSFSTTEKTRDEIVSRMWADLYKGIEMHC
The following text describes a protein:
Function:
Forms a complex with CSN12 that is recruited to transcribed genes and required for transcription elongation. May also be involved in pre-mRNA splicing.
Miscellaneous:
MISCELLANEOUS: Present with 3360 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MQNPYGHFTNNTTEDREASSQGGPFGQSLNRPLDYAGSFPSLTYNNNNFIANQQPSLPLPEPRLSWNNVNQVSNPLMVTPLPGLQKRMNKNIKKKLPRVSKKASALSNGVSGNVMSNSNIVGHGAVGSASGWKVEMGGSDELERRKRRAERFSQGPSATTNSNDNLNEDFANLNAISSKSHQYDKKIHVVGRCQTLEKSYLRLTSEPNPDLIRPPNILQKMYCLLMDKYQSKTATYTYLCDQFKSMRQDLRVQMIENSFTIKVYQTHARIALENGDLGEFNQCQNRIMALFENPTIPKKSYSEFICYSVLYSMLTEDYPSISHLKLKLIDDGSSEILEDEHVKMIFELSDMKLVGNYHYFMKNYLKLHKFEKCLINSFLNLEKLIFLTIICKSYNQVNLDFVKSEFNFNSIEETTNFLNEQNLTEFILNKQITDSNGKSSNIKILNTKGCRVQLIQNYMKSKKIDIKGQK
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MESTGSSGRLWELQFERSSGWRGAFTVLTDSAPSSAELQVPGSLAAAVVKCRVELAQDDSWRMESVLSKYENQITIFADYLEEFPDSDELVWILGKQHLLKTEKSKLLSDIRARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPREYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAIYVSMDNTVVIEDIKKMCCVLPLSADTIGESPLNTLNASNQSKSAPASCPAWKPLLLIVPLRLGINQINPVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEENGTVDDQTFHCLQSPQRMNILNLDPSVALGFFCKEEKDFDSWCSLVQKEILKENLRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFIDSTEQLEDFDLEEDFEILSV
The following text describes a protein:
Function:
FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-hexaprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-hexaprenyl)benzoic acid. Also acts downstream of COQ4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-hexaprenyl)phenol to 2-methoxy-6-(all-trans-hexaprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly from NADPH via ferredoxin (YAH1) and ferredoxin reductase (ARH1) to COQ6. Can also convert 3-hexaprenyl-4-aminobenzoic acid (HAB), a COQ2-prenylated pABA, to DHHB in a two step process. HAB is first hydroxylated at C5 to yield 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) which is further deaminated at C4 by COQ6 to produce DHHB.
Miscellaneous:
MISCELLANEOUS: Present with 2940 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MFFSKVMLTRRILVRGLATAKSSAPKLTDVLIVGGGPAGLTLAASIKNSPQLKDLKTTLVDMVDLKDKLSDFYNSPPDYFTNRIVSVTPRSIHFLENNAGATLMHDRIQSYDGLYVTDGCSKATLDLARDSMLCMIEIINIQASLYNRISQYDSKKDSIDIIDNTKVVNIKHSDPNDPLSWPLVTLSNGEVYKTRLLVGADGFNSPTRRFSQIPSRGWMYNAYGVVASMKLEYPPFKLRGWQRFLPTGPIAHLPMPENNATLVWSSSERLSRLLLSLPPESFTALINAAFVLEDADMNYYYRTLEDGSMDTDKLIEDIKFRTEEIYATLKDESDIDEIYPPRVVSIIDKTRARFPLKLTHADRYCTDRVALVGDAAHTTHPLAGQGLNMGQTDVHGLVYALEKAMERGLDIGSSLSLEPFWAERYPSNNVLLGMADKLFKLYHTNFPPVVALRTFGLNLTNKIGPVKNMIIDTLGGNEK
The following text describes a protein:
Function:
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
Sequence:
MVLLYTPKQKTKNVQTITADILDLDYQGLGVAKINGKTWFIENALPHEKVECRILEDKRQYGHAIVKKWRVKSPERLEPKCAHFMRCGGCQGQHIPIEMQRKAKESALFKRLSKLQSEPISFQPMICGDAWAYRRRVRLSLWFNPSTKQIEMGFRQKNTNDLIPVQSCEVAEPAINYLLPKLTALLEKFSAPKQLGHIELVAADNGVAMLLRYTKNLAEIDRTLLLKFAEQEKLMLFLQSDKGIEQIYGDAPYYQFSDGIKLHFDIRDFIQVNSALNEPMVNTALDWLELSQQDCVLDLFCGMGNFTLPLAKRVKSAVGIEGVFEMVQKAAQNAERNQIKNIEFFQADLDQSFVEQPWANQSFNKILLDPPRSGAAFALNALCELKAEKILYVSCNPATLVRDAEILCNFGYKIEKSAVIDMFPHTGHLESITLFTTK
The following text describes a protein:
Function:
Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MKSLLCLVLIPLCWAAHHGNSTVYLDRIIHIHENGPRLVVEVEQTKVITHRGGNATLPCKFQHESITAGSPSHKIRIKWTKLTSDYLKEIDVFVSMGHHKRTYGSYQGRVYLQGASENDASLVITDITLEDYGRYKCEVIEGLEDDTAVISLDLQGVVYPFFPRMGRYNLNFHEAQQACQDQDAIIASFDQLYDAWRSGLDWCNAGWLSDGSVQYPITNPREPCGGKHTVPGVRNYGYRDKDKGRYDVFCFTSNFKGRFYYLIHPTKLTYDEAVQACINDGAQIAKVGQMYAAWKLLAYDRCDGGWLADGSVRYPISRPRRRCSPNEAAVRFVGFPDKKHKLYGVYCYKA
The following text describes a protein:
Function:
Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. Acts as a transcriptional modulator for ESR1.
Subcellular Localization:
Nucleus. Note=Colocalizes with ESR1 in the nucleus.
Sequence:
MAEGEKNQDFTFKMESPSDSAVVLPSTPQASANPSSPYTNSSRKQPMSATLRERLRKTRFSFNSSYNVVKRLKVESEENDQTFSEKPASSTEENCLEFQESFKHIDSEFEENTNLKNTLKNLNVCESQSLDSGSCSALQNEFVSEKLPKQRLNAEKAKLVKQVQEKEDLLRRLKLVKMYRSKNDLSQLQLLIKKWRSCSQLLLYELQSAVSEENKKLSLTQLIDHYGLDDKLLHYNRSEEEFIDV
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAVELGQQMVELGAMVRLAAEESYLALRDLVEMSRTEAEAEAQGKEGVRLRSDTEKKIDLLKFVDRTRQRMLRLHVLAKWCQQVPLVNYCQQLASTLSSHETCFTQTADSLFFMHDGLQQARAPIFDVPFATEVLRTGSYRRLPKCIEEIGTQNTLFQDERRPTLKILNTLVRAKLLETSLPKEISEVSVTDGIANLCVHGEFKVLLTLGYRGHFSLWRLLHMELLVGDKTGPITLEETRRYALGDDIERRMANTDNPLMILYTVLHELCISLVMDTLIRQANILRQGRWKDAIKSELISDNSAAQVGNNAPVQLGQDGELDQSGFRIPGLKVNYWLDENISGSTEPDVSPFISIEAGKDMRINCLHSSFILDPLTDKEVDLSIDLSCIDVEALILKAIACNRHTRLLEIQRELSKNVQISQSPADVVLKREVIHVDSLGKKVDGSNFGNCTNEVLQVRAYGQLYIHLGINIRSGRLLLQSSKNILLPSALLESEEALNKGSLTASEVFVSLKTRSILHLFAAIGRFLGHKVYSQSQVPLKIPKSVLYGSDFTVMGFPQCTNAYYLMIQLDNDLTPVFHLLETQTDESNKSSTDSTTDANQAVRFNRINISHMQIGEEKYSLNLFDSEKPLEHMVNYNQCIEGRNVKLLPLTPSLSPSFSSLVDEVFEHNLSSSTTENQLLPPHSLASNHLNSYQVGAVGVSGTVCPPELDGNFMHSDINFSEVKPGVSLNSDLLSNLNHFKCTNAISSSGTAHISLMSSNCKSGHDLTSLRSSGGHNIVHGGESLQPVSSDGQGVLGNTSTMQFGGSSRKRSLSEFLLSIPSLQQSRISEGPRKRRKAPEHMKDGILFKEYSSSAQSGKTVTYGNIFTEEKCCITSAFYASLLCRVIKHCSHLIKYAQLTTQMDSLGISYAEEVVLWTPSSNLCLRLPFLKEDSWKHVCLRLGKSGCMSWDVRINDPYYGSLWKVHGGSATTEWGIGVCIAKTSEIDSHITFDDDGVVLTYHTVEADSIRRLVSDLRRLSNARAFCCQMRRLIGVKVDDKRDEKATSVEINARKGSRHRLSEQMRKTFRIEAIGLMSLWFSYVVVPMVHFVVEWKAGDGGCFVHVSPDQLWPHTKFLEDFVNVGEVASFLDSIRLTAGPLLAFSSAIRPAKMPVTLPAGYSSVPKQNSYRSEGASANGSSTTVQNTSAPLNPAVAHSNKHNLQSSVLTIAGRGGPGLVPSPSLPFDVTVVLRGPYWIRVIYRKIFSFDIRCFSGDQVWLQPATPPKGGPSIGGSLPCPQFRPFILEHVAQGLNTFEPSVMSARHSSVQLKASINKASGGQQSALALNRFHGAHGIATSGPTTNVGNQVAPTFIRADSTVVASSKYASGNAGAPPHLSPGINLPVHMRSELSSTLTAVGDDGGYGGAWVPLAALKKVLRGILKYLGVLWLFSQFPELLKEILGSVLNENEGALLNLDQEQPALRFFVGGYVFAVSVQRVQLLLQVLNVKRFHHHQQKNQQQAQSPAQEELATSEINEICDYFSTRVVCEPYDASRVASFVTLLTLPIPVLQEFISLLVWKKSQSQVHGEIASAYRVQVELCLETHHGSVSNDHAESLSSSKSNIKHDRANRSVDFGLTFALDHTLKHNSSVGGAAWLPYCVSVRLRYTFGDNCHVTCLAVEGSHGGKSFWLRYEDWENCKQMVARTVETANESPAIGETGKGRLRLVAEMIHKQLQLSLHQLTLPAG
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MSARKRKGMGSCPPNAPLIWARDGDHENAAEHPAYLLPSPPGDHTSSHVEEECVWIKWASNGTTAFIPKSRISSELSSRRRRGRDGSDSMPENTASAGSANAREEGSEIDTEQNIKPTVKKKKKLSLSMKQRLQWREHNDHQRQNSNSKLQRKSPPEQLLHEHHVSNNVGSSLELDNIKQSSLRHSQKANDKAKYSSKIGLQQSTSDTSPEATVETLASTVVDAMSEEKTDGNQFHVDTAKNTAVEVIEIGDDDNEEEKKEDIDSTRRHEPLKAQHFFPPDELDAFAETKQAPSLQTKQHQTQSRSETSPSTLPDHSYSNKSSAYIQHIAEACTLIMTDARWRTCDNKRPCQCNVKSYDGEKKCIGKALLSWEDGDDLSAVKAFMSLYDEGGRGGKDNGDGRNDEEEPDQVATNDHSSLLKSDETTKSTETVNGGSGSLADEVFERSMHLYSRMFHRKGPWFDLTDLYIRYYAPKTKRQSAIEDQVGVAVDRSDVETFTSCNEPVASDSTNAVMADTREKAKNFFTPKSTRKDSKQSNTKKRYAEQLRRHREALKCFFTDVIRLLSMGLVRTFQSEYECGSVAGNVTSRYSGGVQRGTLLLSDERREVLRRLGGGKSPKAMAPRSDRSEQTTNEILLQMQSQQTVFSAYAFSDGNPKQQMLLPVRKHVDLVLLNKLGAKIASLSEEGTMFKSGKSDMGEVSRMINSAWSDVHQAVNPSSDGSNNGIVTTLRLREAPLMTLRRCLRIFLCAGGGPGSMRGNGRNGWLSVNTASTDLWHTVDYPGLLSRLGLTSFEFKHCYQQLHEDEERECASLVRVFRRFCDFQLWEKGAELRSFVDEMAEAHELERTTWRRQQRALEASSSKTGDELEEMNVFKEPSVSDRFALLTEDGRNAFIQAVIAQCLHDATSSLGRIDTDSVAIKVFRLVESDIIYLQNAVAEDDEDDGFTSDAERLICAVAIICHRILQCRLDHKSQSLSSLLHRPWLRHFSFDAILVYAIWDCIPVFERKGLNSMAVMLLTTILFGSTNHGQYGEEKDGMSRLLEISESVAHPSVQCLLPRRNRGKAFERLVIDISHVDRLLKKKNNAAKPNSKAKNDGKEVNEREIQPIQRLVYSILRSTSKAGSISFCSLRNLARRLKVPLVSTMKNVQNDEMTLLNIRLENENESNQNQNSYSDWTPKTDFAVANALSTGEEAMPCQRCTFVGYDDAEEEKSLNVEQLAMEYYFHGRLPKQDKTDTSLSTEKGYYVGWHCEGGHVRALYRILCMQDLLRYCSCETLFLTPFQASPHDLHVGYSKSFDADTNSYTPIRGFYERRRDVIESFFSRLSDLDSQGVSDLVHDAVKHRVQQHESDWHVMKDVLLQKDISELRTLSMIAAGIGGGALATIFRCLCFDYRLYSGGLPDLLLVRARFVQQLNGNETDSIIVDLGDWIGESFSKENAEEKNVLKRINMLIDRDDEFLGCSKNADGSKLSQRGKTDRGQALTSEPSVTLPAKLEMKHEDKDVTVDCMFVEVKSSNDRLDSRQEDWLNILDGCTNARMCKFEATKKHNNDKTKKK