lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.
Subcellular Localization:
Nucleus.
Sequence:
MSEDEFGDDSIFLDDSFLRQVDTISAQMTAASTSSKNDGLRPVSSIARNSRLATAVSRTASHNEVSPKRSQTMHGVGRTFSAPGPISKALPQQRPAAISRQQAVSKVPPQRSSDEYDTIDIPTESLDAFDAIIANPPKKPSHPVFSGFPPKPSTSALSSRNTSAPSRPSSSFARHPSSSNKQDSLHQTHLNWRSESRYTKGKRWDRTQFAKTGRRIISLAGRDKVSGGKGKERESIAPRWEDDAIDEDEFMDDDMGDVLAPAPRDFNAPYGPQKQLPSKATINTYIYPTNHPKRDYQFEIIRNCFLDNTLVALPTGLGKTFVAGVVMLNFYRWFPTGKIVFLAPTRPLVAQQIEACQLSCGIPSRDAAIMTGEGGARKGRERLWEEKRVFYCTPQTLDNDLKNGAVDPRDIVLVVLDEAHKATGNYAYTTIVAYITAHHPYFRVLALTATPGADVEKVQNVVDALHISRIEIREAEAPEIRKYMNTKHIEKHVVPMSDVIVDFRDRLSALMVPFIKKLVDKDILTERDLDAKRLRPFRITAKKMELGKSGQRWAFGPLGVLDKMARAMSHLLEFSLGMFHSSLDEMVSAGGKSKAGAGGANSIANNFEFQRLQRDVSQELSSIKIGRNGKTGADRHPKMQKALELMLAHFSQAEEEENTLGQKNNTRAMVFCSLRPCVMELVDMFNEHPNLLRATKFVGQSNGKDERDKGFNQKEQKKTINEFKAGTFNILVSTSIGEEGLDIGEVDFVVLYDMPRQSIKLLQRIGRTGRKRDGIVHVLMSENREDMNWDTAQQTHRDIQEEILHSRNLELFEDVEPLIPDRKMPECLEQVMPVDPWNPDDPQYKKMMDEGEKELRRMQRAHQPPASRKKKKPMVNEVPENARGFTSVRDLLREADKVLLRPDTEGEDEDAGGGKSKGKGKGKAKAKDPSAPKIKHRARKRARTPSPIQTESEDGEDQSLEALFAVQEKEDRTEKPSTKRKAPVAKVALVTKRPRKSSPGLSTSSLAKTGSSAKASFPSGKSTVDALKAEQGAVSDADTNNNPVSPSPSPFLKAPSPQPPPALPEQAKAMQQKTIQQKRAEAAEKRRLAEARAAEARLKHVQQPLQQQDQQKREQDQAGLDFFHAEGPLRRGLDPFVATSSSPAKAPSSSPQKLRFSSPSRDPIDDEIILPPSPPQRVNARIATSSKPNGNKLSPRTAAAAGFSQIDPIDLSWDDDDEADAANWQVSPSPHVRPLLPKTPGSSVATRSDMPPPPVPSTSRMGIVASSPFAPLVPSAMSTSVGDTQFPVRRLGMARRRIILPSSEENNSPIGPSNNTDVIHSRMQSSGGVVDPDSSPMVPVGARRRPGRLRRRIAIDPSSSPVRNEPSVGSERPHARVIGREGRREDGRQGGEKKKGPMGNFMDLDAELSGNDSGDTSEHSASSIASSSDLNFANEFAPTQAPKGYNQRAIYLAGLGTQAQGHGLQFKRDMAKEREEFLQRARRPVYITDEEDGGPKRRSSEDEYELGSFIVDDEDDVGFISHSDPLFD
The following text describes a protein:
Function:
Catalyzes the reversible hydration of fumarate to (S)-malate.
Sequence:
MTVIKQEDFIQSICDAFQFISYYHPKDYIDALYKAWQKEENPAAKDAMTQILVNSRMCAENNRPICQDTGIATVFLKVGMNVQWDADMSVEEMVNEGVRRAYTWEGNTLRASVLADPAGKRQNTKDNTPAVIHMSIVPGGKVEVTCAAKGGGSENKSKLAMLNPSDNIVDWVLKTIPTMGAGWCPPGILGIGIGGTPEKAVLMAKESLMSHIDIQELQEKAASGAELSTTEALRLELFEKVNALGIGAQGLGGLTTVLDVKILDYPTHAASKPIAMIPNCAATRHVEFELDGSGPVELTPPRVEDWPDLTYSPDNGKRVDVDKLTKEEVASWKTGDVLLLNGKILTGRDAAHKRLVDMLNKGEELPVDFTNRLIYYVGPVDPVGDEVVGPAGPTTATRMDKFTRQMLEQTDLLGMIGKSERGVATCEAIADNKAVYLMAVGGAAYLVAKAIKSSKVLAFPELGMEAIYEFEVKDMPVTVAVDSKGESIHATAPRKWQAKIGIIPVES
The following text describes a protein:
Function:
Involved in glycoprotein quality control as it is important for the targeting of misfolded glycoproteins for degradation. It trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2) with low efficiency.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MVKRRTVKYFLRRILALFVLCVPIYYLYTTVQRPPGYTKLKGSTRRKALIKKTFIESWTDYETYGWGKDEYYPIIKRGRNYLRKGMGWMIIDSLDTMMIMGLDEQVLRAREWVNNSLTWNQDDEEVSVFETTIRILGGLLSSYHLSQDKLYLDRAVDLADRLLAAYNTSTGLPRSNVNLGTRKSRKRTREYFVSTAESGTVQMELRYLSYLTGDPKYWITADKTMEVLLGDATWSHTGLVPITVNLITGAYVGRNIRLGSHGDSYYEYLLKQDLQLFSSGTVYRKAFDLSVDGIIEYLLNYTTPNHFAYIAELPGGLEHAQLPKMDHLVCFLPGTLMWGATNGTSLEAARTSKNWGTRQERDVKLAQELMRTCYEMYNMTATGLAPEIVFFDVDQTKNEIYSKRRDQHNLMRPETVESLFILYRITRDEIYREWGWNIFVSFLRYSRLPGRDAFTCLDSVESKKVKDQRDKTESFWFAETLKYLYLLFEDDFSILPLTNYTFNTEAHPFPNIENNMDLYTV
The following text describes a protein:
Function:
Transcription factor that affects the expression of a large set of genes. Recognizes and binds to the consensus sequence 5'-[CAT]AGG[TC]A-3' in the promoter region. Plays a major role in the repression of a specific subset of hypoxic genes (e.g. ANB1, DAN1 and HEM13) under aerobic conditions. Acts synergistically with the transcription factor ROX1 to recruit the general repression complex SSN6-TUP1 to the promoter of hypoxic genes. Represses transcription of ergosterol biosynthetic genes. Negatively regulates pheromone-induced gene expression. Can act as a transcriptional activator (e.g. of genes like CYC1, SUC2 and the Ty long terminal repeat delta promoter).
Miscellaneous:
MISCELLANEOUS: [MOT3+] is the prion form of MOT3. [MOT3+] is the result of a conformational change of the cellular MOT3 protein that becomes self-propagating and infectious. This conformational change generates a form of MOT3 that assembles into amyloid fibrils. [MOT3+]-aggregates sequester soluble MOT3, resulting in a loss-of-function phenotype for MOT3. [MOT3+] can be cured by GdnHCl and by inactivation of the molecular chaperone HSP104, which is required for [MOT3+] propagation. It is speculated that prion properties of transcription factors may generate an optimized phenotypic heterogeneity that buffers yeast populations against diverse environmental insults; MISCELLANEOUS: Present with 1690 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The prion domain (PrD) is a Gln/Asn (Q/N)-rich domain, which is unstructured in its native, soluble form, and which forms a parallel in-register beta-sheet in its amyloid form.
Sequence:
MNADHHLQQQQQQRQQHQQQQHQQQQHQHQHQQQQHTILQNVSNTNNIGSDSLASQPFNTTTVSSNKDDVMVNSGARELPMPLHQQQYIYPYYQYTSNNSNNNNVTAGNNMSASPIVHNNSNNSNNSNISASDYTVANNSTSNNNNNNNNNNNNNNNIHPNQFTAAANMNSNAAAAAYYSFPTANMPIPQQDQQYMFNPASYISHYYSAVNSNNNGNNAANNGSNNSSHSAPAPAPGPPHHHHHHSNTHNNLNNGGAVNTNNAPQHHPTIITDQFQFQLQQNPSPNLNLNINPAQPLHLPPGWKINTMPQPRPTTAPNHPPAPVPSSNPVASNLVPAPSSDHKYIHQCQFCEKSFKRKSWLKRHLLSHSQQRHFLCPWCLSRQKRKDNLLQHMKLKHTNYLLDELKKNNIIFNYNNSSSSNNNNDNNNNNNSNSASGSGGAGAAAAAATAPENEDGNGYDTNIKTLINDGVLNKDDVKRVLNNLIVSHNK
The following text describes a protein:
Function:
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
Subcellular Localization:
Nucleus.
Sequence:
MSGIGGIGVLLEAAQFLEQHEKLPQAGGGGGSALGVGVALPQQQQQTVHCKSNSIINNNNSSQHNRNSSSSSNGIIATPPFTNGNGNGTVGVGNASAIFNVSVNANGNGLSNGHSSPRSQLAAAATAHDYEYSAAGVANGHSEGRPHVSEDDNSSINNNNNNNNTHPPQQQQHSAAGRTTTTRITTTPAILTKLMGNSVTPASNTTSLPTSTPSVTTSPPASTDFMLLAAAATSATSATPATATSAAATAASNPAKRKLSSIAEIPSKFLVVSDAKGVYSAHTHPNGFAADSLGVDNNETMIKKLMQNLQSQRQQQSLQQLRSLRPAEISLTPPPAATRKVDISNSRTRSYSLSNVSAARDQQDHPQHQQHANHMQIQQHYGYMRSNIGGVIYGLHKDSADSAASSACGAGAGAAAVGMSIASSAPAAGSQLSAHHHTGHGGRRRTTSSNSNGAGTREVHNKLEKERRAQLKECYDLLKKVLPMGDEDRKKTSNLTILDTAHKYVNSLSHEVCEQEAKIEKLAKQKIELQKRLKQLSLRRESPPTDQQIIPQADKVCLATTATTAPPTAASGHNGTTILFDAGNACATGQLTTVINKTNGGATAAASSKHNGNHTGGATTTLTPAMGIMTIKNGNGSNGNMLAISPTGGHNHQLHQHHNGSPAGSPSGIGATTGATITRGSPTPSTPSPSPSSSSSGVSLSTSFMGGSSSSSSSSSSSSSSSSSSSSSSPTQQQQIITPTATARSVGLKFHGGAGAAVPAGGGSVNGFHQADKDRNYTFLRLSAGTTAQ
The following text describes a protein:
Function:
Catalyzes the hydration of cyclohexyl isocyanide to N-cyclohexylformamide. Acts on various isonitriles, but not on nitriles or amides. Probably involved in detoxification.
Miscellaneous:
MISCELLANEOUS: Does not require metal ion for activity.
Sequence:
MALQIGFLLFPQVQQLDLTGPYDVLASLPDVQVHLVWKDLVPVTSSTGLQLKPTTTFEDCPVLDVICVPGGAGVGPLMEDEQTLDFIRSQAAQARYVTSVCTGSLVLGAAGLLQGKRATTHWAYHDLLPTLGAIPVKDRVVRDGNLFTGGGITAGIDFALTLAQELVGVDTAQLVQLQLEYAPAPPFDSGSPDTAPSAVVDEARKRAAPSLKLRTEITERAAAKLNLR
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet.
Subcellular Localization:
Nucleus.
Sequence:
MAAPPGEAPLTAATNIEPFYVLHKGGAAASSSSSSAPSLPSSGRARRRIDVSGLASPNPKPGKRSRDDDAAEDDDDDELYERLRLDAFHRVWSKIQSTINEVLRGISLKLFDQVLRWVQESFSAVRSIARPSAAEVRQPYPLLTDVICRKIPTAFVLTKNAEFVDDITTFRDLAEYLESNGCHLAKLSATELSEKNGVGCCFRSLLRQLLSDVPDVADIFALASWYSAAENYDQPIVVVIDDLEQCSGDVLGELVMMLSEWVIKIPIFFVMGIATTLDAPRKLLSSEDLQRLEPCKLTLGSPSDRMNALVEAILVKPCAGFCISHEVAVFLRNYFFKHDGTITSFISALKLACSKHFSVEPLSFLCMGMLEEDRENFWHDKFNALPQELRKYASGLPSCTREKDSTKSGDNMVDGLSELMNIQKDWSSVLLCLYEAGKHGKVQLLDIFCEAVNPDLHTQKAPNLPNEKSGTSRRFIDQVMDTIRYLPVETLFCLLEVWSIHLNGMDKITNKVKELQSTTISTDSVRITKDKWPRRSTNSTGNSTVALNDKVAMLLDDVTRKFLVSVECLPFHEIVCFKNVSILQSALIGNPRRMVQLDLVKSHKHLKCSCCRKNGIAVLASMHDTSIMCNLAQEYGDVINLHDWYISFDGIINSVHSKIKRKPHTSPSKKKSKPVAAESEAMIQARFCRAVTELQITGLLRMPSKRRPDLVQRIAFGL
The following text describes a protein:
Function:
Could be involved in a ubiquitin-related process important for DNA damage tolerance. Acts in a process which is defective in the checkpoint rad mutants and which involves hus5.
Sequence:
MGNHNINAEEIALYDRQIRLWGFNAQQALKQSRVLLITASPLANEIAKNLVLSGIGKLCVLDSMTVYEKDVEEQFFIEASDIGQLRANVFKKKLHELNPLVEIDTDTSLISEIDEGKISKFSMVIATQLDYEEFCRINELTRICNASFYATSCFGLYGFAFCDLINHNFAIDRVVDNTKVEEDMFIVQKPMKEAFQSILGETLKPRLAKKIPTLYPAMLSLLKSKKSDPDSIRQVCIEQKLNEKTVLNGEFLSKFSSNISFQWTPVMSVVGGVVSQDALNSISKKQFPIDNFWIFDAESGLAPIYRL
The following text describes a protein:
Function:
Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis. Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis. Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAGRPELGDPLGEGAWGAEGPVSSCLAGNRLNLDVYAEGCLSFLRLFETRSEEVEQVEFLRLSCNEEHIASILSIIPALKGLKSLVLKGGHTRDEAGACQRGLLFSLPQELGELTQLAHLDLSFNNFTALPPCVTKLLSLRSLLISHNSLQELPEDFGQLSELTFFSAMKNQLRDLPQGIGELVALQTLDLSENALKSLPEEIGNLHSCMELDLSGNLLTGIPASLANLQSLQQLHLHSNLLVTVPASLAHLPNLSRLDLQNNRLRTIPPEIQSLPFVHLRGNPLGEPEVPLQPENSTSEEPRRLFIETGESSFIVTPDGCRVSLACGIQLSFPPGATTTSVTIHFQKCFPDPQWVKLKHHDVLLSKVLELQPHGIGFQKEVQIQMPYASPQSLNDREIIIRTLSGEKWSELGTRVKHKGKMHFACCSVPHFSWFVVVSRLVENECRVPQEGALLFSTVDPNIKVTFPPGVTEETRTVKLQVLPVSAEELQEITEDNEMVTSPLLFLSQNSPADFLQPVKIQLPLPPGVTGLTLDRSRVHLLHGDRNAQNWDDITDQVVLEFTHLYALFEVTHFSWYWLWCTTKSYIDGIAKKVYKRLRMYQVNFIALQRKKDPEQVLLQCVPKHKVDPVLKKLQDRYRGPEPSDMVEMLEGEQFFAAFERGISIDADRPDCIDGRISFNFFSHLKNVKEVYITSEVDRKSTAVKGQVSFYRGAVPENIPEEVSKRRKGPDSHWLATLPIKLPKLKSQENKQPTTSNGFSLPPLNLGNAETGYLTQSNLLGIAGRIGADWQTIGLHLGLSYQQIQRIQYNNREDLNTQILDMLFSWAQQNEKKPDCVDQLICAMKESDRQDIADEIVAIIALGKQKYRESIRRVGLDQESSTEDSAIAMM
The following text describes a protein:
Function:
Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSDESDDKTEAPTPHRLEKAREEGQIPRSRELTSLLILLVGVSVIWFGGVSLARRLSGMLSAGLHFDHSIINDPNLILGQIILLIREAMLALLPLISGVVLVALISPVMLGGLVFSGKSLQPKFSKLNPLPGIKRMFSAQTGAELLKAILKTILVGSVTGFFLWHHWPQMMRLMAESPITAMGNAMDLVGLCALLVVLGVIPMVGFDVFFQIFSHLKKLRMSRQDIRDEFKQSEGDPHVKGRIRQMQRAAARRRMMADVPKADVIVNNPTHYSVALQYDENKMSAPKVVAKGAGLVALRIREIGAENNVPTLEAPPLARALYRHAEIGQQIPGQLYAAVAEVLAWVWQLKRWRLAGGQRPVQPTHLPVPEALDFINEKPTHE
The following text describes a protein:
Function:
Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1 (By similarity).
Sequence:
MENREPKLKQAPYFRCEKGPNWVPVCQKCEACVLAWKIFATKEWFRRVNDISQRRFLVSILGQLNSLYLLQYFQNILETTQGKDFIYNRSRIKLSRKGGKEEEVVKSSLNQMLDKTVERKMKEILYWFGNSTHRTKANYTLLLLQMCDSNLLLTAANVIRVLFMKEWNSISGLHDDTPDVMFFPEKKYSGTQDTSYVSWAARPKPVSFPMSKHLGNKLGTENVDRETTEGKGESSLQCIHEMNRQIFGKGGMSRLGDDPCNLLLSLDHVQLLSSGYSKYRDFIRDLPLHLSKYILRMLDKHSLNRCIFVSQHWATLAQQVKVDQSMHSFIQNQISLLQVTKEEKQAYTGSYTRGIDPNYANKVSIPVPKIVDDGKRSRSKNQKWKLRTKTDYNLWNAYQNQETQLVQMEERNVFCGTYNIRVLSDTFDQNRIIHYNGGDLMAISSNRKIHLLDIMQTKELPIEFRGHAGSVRALFLSEEDNILLSGSYDLSIRYWDVKTGACVRIFYGHQGTITCLDVYKNRLVSGAKDGQVKEWDIETGKCLKTFKHKDPILAAKISETYIVSSCERGIVKVWHVVTAQLQKTLTGHEGAVKCLFFNEWHLVSGGADGLVMAWSMVGKYERCLMAFKHPKEVLQVSLLYLRVISACGDGKIRIYNFLNGNCLKVIKVDARGDPVLSFFYQGNRMVAHTDSNILVFQFENVKWQYSSDKNKVKKSKDKEEEREETSLGDEHSRSTIQGHSLKDSVSSKQEFSKSRVHLKQTKNLSSDDMETPVGEVSHPLQKLWKVPMTPDRFLLTISALQQAHNSEEFAYPHRPRPQVIDAWGPSIPYPRKVLSLKGKSVQHAVDQLRSSNLPTGVRQTNIPLEIQKLQPNLKKSLHSPRVQATVPQPSLIRPKVSDSLRGDEHLTSSIDGTMRRAGPLTSMQVIKPNRMLAPRGGTATLSPKKERPRFYTTLDPLRMNTGFMLMTVKEEKEFAEAKMKEYEASVSTKEVDPGKASKAAWIRKIKGLPIDNFMKEGKTAAPELGQNVFI
The following text describes a protein:
Function:
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
Subcellular Localization:
Cytoplasm.
Sequence:
MDPRSEVLLRQRHLFATPLLLAGLPADDLLAELPQAQGWSWHAGEQAQLDARFPGRSRFDTRAPTGAWTSAVLFLPKSRELTDYLLASLAARLPGGELFLVGEKRGGIERASKQLAAYGKPRKLDSARHCQLWQVRIEQAPAEPDLHALAQRYSLPLADGELQVVSLPGVFSHGRLDRGSALLLGQLQALPGGHLLDFGCGAGVLGAVLKRRYPASRLSLLDVDAFAVESSRLTLAANGLDGEVIAADGIDGAPRELAAIVSNPPFHQGVHTDYQASERLLQRAAEHLAPGGELRLVANSFLKYPPLIERHLGPCRTLAEGDGFRIYSARRS
The following text describes a protein:
Function:
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
Subcellular Localization:
Cytoplasm.
Sequence:
MARIARGHLIPALSILPTRSCLSANPSPFASRPHLAAVLGSRRRFSCSSRLSMSLKAGIVGLPNVGKSTLFNAVVENGKAQAANFPFCTIEPNVGIVAVPDPRLHVLSDLSKSQRAVPASIEFVDIAGLVKGASQGEGLGNKFLSHIREVDSILQVVRCFEDNDIVHVNGKVDPKSDIDVINLELIFTDLDQIQKRIEKLKKGKARDSQSKVKEDAEKSALEKIEQALLDGKPARSASLTDFENDAIKHLCLLTMKPVIYVANVAESELAEPANNPYVKEVMNLASELKSGLVTISAQVEAELTELPSEERTEYLISLGVSESGLGNLIRATYGLLGLRTYFTSGEKETKAWTILAGMTAPQAAGVIHSDFEKGFIRAETVAYDDFVTAGSFAAAREKGVLRSEGKDYVVQEGDVMLFRFNV
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MAATLWAFFSVLLLLLSRDAQSSEVSGSTSDGSGGSGVGTGDRFKIEGRAVVPGVKPQDWISAARVLVDGEEHVGFLKTDGSFVVHDIPSGSYVVEVISPAYRFDPVRVDITSKGKMRARYVNYIKTSEVVRLPYPLQMKSSGPPSYFIKRESWGWTDFLMNPMVMMMVLPLLIFVLLPKVVNTSDPDMRREMEQSMNMLNSNHELPDVSEFMTRLFSSKSSDKSSSGSSKTGKSGAGKRR
The following text describes a protein:
Function:
Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Acts in the intestine to regulate both innate immunity by promoting activation of pmk-1 and also stress response and life span by acting as an upstream, negative regulator of the daf-16 transcription factor (By similarity).
Subcellular Localization:
Cytoplasm. Membrane. Note=Translocation to the cell membrane is required for kinase activation.
Sequence:
MDANDFPRLFYTSMPSSSTSNHRIDRLSSSSSSTFRRDDFRRHSTTTSSEKFSTISIGESVKLEEENGEIPEKFVQEEDTVVKTEETRVSDCDFSLTFYTAHVTSSSMLSRGDSSSINNKTFTPDDHYSNPSDKRREVPSIRSTSSNSSSFGGHVAFVDEPSEENQRQQQQYQQHQFQLPTLLVTSTPSTVFDQNDDDVFTSPYHPPNRQYSSSSEMSGLSFQLQSGIHKKSIAVEGNEIALRDLRNEAFQFVKEIYPEKKCGSLEDYILLYKHDLRSINILQLITTSSDVTDGTLVEIVIGSCPQNERIVVHPHTLFVHSYKVPTFCDFCGELLFGLVKQGLKCFGCGLNYHKRCASKIPNNCNGSKQRRPSAIPLSPSNSNILNLNERRQSRRDSCLEALDAARPSSTLGGAATPNIFITSDDCGDPVGGNFLQMPRKDRSCSWSGRPLWMEIAEATRVKIQVPHTFQVHSYKLPTVCQHCKKLLKGLLRQGMQCRGENETEKLQNGAVAKYCKYNCHKKCSEHVAKDCSGNTKASQFFLGTADDGVSEDRDDDLSLRSGSGGHKKAQNTPSAPLQGSEGSGSPGGAVVSFAQGLSNAPDDDVISSESANIPLMRVVMSKKQTKRKNNKLLKEGWIVHYTDQQNMRKKHYWRLDTKGITMYQDENTTRYYKEIPLNEILGVMTSSPEKSSEYLFEIRTGACVYFVYSSLTDEELYNIIHASPCIARKPSTVSSTDSGYLGSSGASSSCVRSREGSTVSSTITVDRTRRGGSTTSTENSEAESESSYSSFASIASTASKYLGRAADCLVLMTKRNGWSDAGSPADEKSSGSLDAQSWTTAIQSALMPVTPQSSVVGGKRVDKLKVPTEGETGHLGAKIQTEQEFSQLYQIFAEEVLGSGQFGTVYGGIHRRNGQHVAVKLIDKLKFPPNKEDLLRAEVQILEQVDHPGVVHFMQMLETTDRIFVVMEKLKGDMLEMILSSEKGRLSERTTQFLVAQILEALRYLHHQNIVHCDLKPENILLNSNSDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGFNRSLDMWSVGVIVYVSLSGTFPFNEDEDINDQIQNAEFMYPPSPWKEISENAIEFINGLLQVKMSKRYTVAKAQSHIWMQNYTIWSDLRVLEKAVGQRFVTHESDDSRWHAYEKEHNVTPVYV
The following text describes a protein:
Function:
Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). Upon phosphorylation by GraS, functions as a transcription regulator by direct binding to promoter regions of target genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis.
Subcellular Localization:
Cytoplasm.
Sequence:
MQILLVEDDNTLFQELKKELEQWDFNVAGIEDFGKVMDTFESFNPEIVILDVQLPKYDGFYWCRKMREVSNVPILFLSSRDNPMDQVMSMELGADDYMQKPFYTNVLIAKLQAIYRRVYEFTAEEKRTLTWQDAVVDLSKDSIQKGDQTIFLSKTEMIILEILITKKNQIVSRDTIITALWDDEAFVSDNTLTVNVNRLRKKLSEISMDSAIETKVGKGYMAHE
The following text describes a protein:
Function:
Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Note=Translocates to the cytoplasm in the presence of STK3/MST2 and STK4/MST1.
Sequence:
MDYTHQTALIPCGQDKYMPKSELLLHLKTYNLYYEGQNLQLRHREEEDEFIVEGLLNISWGLRRPIRLQMQDDHERIRPPPSSSSWHSGCNLGAQGTTLKPLTVPTVQISEVDMPVENMEMHSPTDSRGLKPVQEDTPQLMRTRSDVGVRRRGNVRTSSDQRRIRRHRFSINGHFYNHKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGEKQKLKNSDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEEDREVEKLMQKYTVLRLMIRQRLEEIAETPETI
The following text describes a protein:
Function:
May function as monooxygenase and play a role in the metabolism of aromatic compounds.
Sequence:
MATLLQLHFAFNGPFGDAMAEQLKPLAESINQEPGFLWKVWTESEKNHEAGGIYLFTDEKSALAYLEKHTARLKNLGVEEVVAKVFDVNEPLSQINQAKLA
The following text describes a protein:
Function:
Involved in olefin biosynthesis. Catalyzes a non-decarboxylative head-to-head Claisen condensation of two acyl-CoA molecules, generating an (R)-2-alkyl-3-oxoalkanoate (By similarity). The S.oneidensis oleABCD genes produce 3,6,9,12,15,19,22,25,28-hentriacontanonaene, which may aid the cells in adapting to a sudden drop in temperature.
Sequence:
MKYSRVFINSLAYELAPVVVSSSELESRLAPLYQKFRIPMGQLAALTGITERRWWPKGHQLSDGAINAAHKAIAETGIDVAELGAVVYTGVCRDQHEPATACRIAAALGVSKDTAIYDISNACLGVLSGILDIANRIELGQIKAGMVVSCESARDIVDVTIDNMLADPTMQNFAQSLATLTGGSGAVAVILTDGSLPLTNVRKHQLLGASHLSAPQHHQLCQWGLQEVGHNIYREFMRTDAVTLLKEGVELAKHTWEHFLAQRNWLVEQVDKVICHQVGASNRKQVLSALNIPPEKEFPTYQLLGNMGTVSLPVTAAMAHDQGFLRPGDQVSFLGIGSGLNCMMLGIKW
The following text describes a protein:
Function:
Phospholipase that plays a critical role during oogenesis, ovulation, and/or embryogenesis.
Sequence:
MTTTNKDGPFRQQYLPGVHKEPNLAISESTHSSDWYSATSSEDCFQAASQSFSSQKSNGNVITQQPGKLHCEISDPKSCSFVPAISTDNAQMGTSGIIKYRSYSNPDLLVAMSPLAYRDEAPQSQKSVANSRQDLTQTSCEVVTVSETVVNADSITTTTVTSSTTTTATASQEDFIMVEAEQDETAGLCDATMPLVDKKNITTSSTTSSPSRQITPRIENGLSFENVVSLVKIFPAFVNKLLKKPWYASRCDEVCQFPKAELAYYDIVSTDVDDEHFVIVAGKVTTDEHLMDNQFHLVFAPVGFSEDVSLDERPFSLFRATDKKDLMDLLHLCDEKSFLFTSLDMSTMRADILRSKIEELVIQIRLKPHYHMIHVAIATDRLDFFSDGMIKTMNETLEPFESQLRCLCHTENCYPVHLALTMDRQKIVERLLELDPTLFCETDKAGNNVWHHVNSSFCAQIIWDRCPASQHFIDERNMDGQSPLNEAVSTAKPLVATFLIGKGAKFTRGDRNELFVAMTSKNAQSVVEVVLTDKPEIANERDALGNSAIHVALYKESLNALLNRKVELGLDIDVKNNAGETALLLFITTRKPDLLPLLVTLYAHGANMNATDPHGNTALHKSAALVDAKKISLECVKFLISAGSNPNKINLRGESPRHLAASLQNQEMLAILKAAGATRCPKGYKGCRSNCRHDCSSAEDEYEETLQKIRIGNESDYEKTEFTASEKLNIQDTLDGSRRGKKAKVNLISMDGGGIRGLVIIQTLIAIEERLGDDIFKYFDWSAGTSTGSLIMAGLATGKSLREMQQTYLLLKDRVFDGIMPPYDTVQLEKFIQDQFGTGTVWEIPYPRLMISAVNSEKLPVRLEMARNYKPAKDVAPETPKEMPLWMALRRSTAAPVLFKPSEDRYIDGGIISNNPALDLMSEVHAYNRELQLSGRKSDAVQMNVLVSFGTGQIPSTVIETLSIDSNSPLQSIKTIKNLAAMFIDQATASEGAPVARSRQWADSLEIPFFRFSAPLSKNIFLSSTSDLDVCTMMWDSFIYCRKHRDYIDELVKVLKHDTDHPHVKTPFTDL
The following text describes a protein:
Function:
Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). May play a role in the innate immune response.
Subcellular Localization:
Secreted.
Sequence:
MGRMWASEVLLLLLLGSSRAVTPGLDVSTAPGLDGSIPPGLDGSVSPGLDGSVSPGLDGSASPGLDGSVSPGLDGSASPGLDGSTPAGRDGTITPKLEGTITPKQDGSISPSWPWRWPITYLDAILAAVRLLNQKISGPCILRLREAQPRPGWVGTLQRRREVSFLVEDGPCPPGVDCRSCEPGALQHCVGTVSIEQQPTAELRCRPLRPQPIRNWWIRIWEWLNGIRKRLRQRSPFYVRGHLNVTSTPQP
The following text describes a protein:
Function:
Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTLQHTKKTYTLNTGDKIPAIGLGTWQSKPNEVREAVKAALLKGYRHIDTALAYGNEAEVGQGIRDSGIPREEIWITTKLDNTWHHRVQEGIDSSLKSLGVEYVDLYLMHWPCSTDPNDKSKHLPDWDFIKTWQEMQKLPATGKVRNIGVSNFGIRNLEKLLNDPSTKIVPAVNQIELHPNNPSPKLVAYNTSKGIHSTGYSCLGSTNSPLYKDQTLLQIAEKKGKTPQQVLLQWGLQKGWSVIPKSVSEERIGKNFELDGWDLTADEVNQLDNLKGRFKVCGDSWLPVKVFFGDDE
The following text describes a protein:
Function:
RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.
Sequence:
MPQNSLSMFRLGHIGGSADESHSASPNVARHAARHSLESNALYSTEGNHESSTPTAMSRPAPLQSSYSTNDLPTVKGDSFNPAITPPKTHAEQFHHHNVSLGRIPVTAVTPRQQKDSPERDEAKSFPSKSQPTTLQPNAPPFGPQLGAATSGNGTMPQPSLAGFPQPFFYGIQPFVAPPLPVNGQYNQSTPFAANAYYGNGNYRLVESQPKPVGSRRHADGDSAQLSRFNNHPIEYYRNEIYGLCKDQHGCRYLQRKLEERNDDQLQMIFAETHSHVIELMTDPFGNYLCQKLLEYSNDEQRTVLVNKAAPQLVKIALNQHGTRALQKMIEFISTEEQTQTVIDALKDHVVELVQDLNGNHVIQKCLNRLTAEKSQFIYDAVGAQCVTVGTHRHGCCVLQRCIDHASGAQRARLIEQITENAFALVQDPFGNYVVQYILDLAEARFTEPLCREFLSRIPKLSKHKFSSNVIEKCLRTADEEMRRQMIEEMLAGDELEKMLRDSYANYVVQTAMDYADPATRARIVKYIEPILPSLRGTPHGRRIGSKIAPENSGRSSAAASGQVTPNEMNSAQLPQGSLQTPQKPLMYHHNSYSVSGTPFNNQSFIPVAGTGSNTPSGASENSSGAYSAALKQSNNNLGAQPQLYAPYYH
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MSRSVAMDLLGGAEKQEENEEAAGICNAGAGKRSDSGDREKEIREALARLALFLKQSQDGDAQGTRSTTMNAKPPAQLTIFYNGSVNVFDDIPPEKAQAIMLFAAAGAASAKTPSMLKSANVSSSSPPALTRTPSFHSTTSAAPQPQIVPAKLQSELPIARKHSLQRFFEKRRDRLTSRSPYPSPSASKAGSAGSQAEEAMEVMDNEKEKMSNTHPLSPHVGCSYEAQHTSPSPIPPTNFA
The following text describes a protein:
Function:
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.
Sequence:
MPAEKRVKYILVTGGVISGVGKGIISSSLGVLLKNNGYKVSAIKIDPYLNIDAGTFSPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTRDNNITTGKMFKHVMERERRGDYCGKTVQMIPHLTDAIVDWVERVAQIPVDGTNEQPDVCIIELGGTIGDIEGMTYLSAFERFQRPTLKNHLMNVHVSLILHPNATGEPKTKPMQNSVRHLRAAGLVPDLLICRSTEQLDPHLREKIARFGMMDLEQVVGVHDVSNIYKVPLLLQQQGVLEAIKHRLKRVEIHHETLDQPFRAVRKLPYQISLSVSFRCDTFQQVVNIALVGKYVKIADAYASVNKALSHAAIHAKRKLKIIYVDSELLEKAGEQSEAAWNQVKAADGVIVPGGFDRRGVEGMIKCAEYCRKNNVPYLGVCLGMQVAAVEFARNVLGIQGANSTEFNADLHEDQQIVIDMPEHNVEEKGLGGTMRLGRRSTVFLTDDCTLHRLYGAHTVEERHRHRYEVNPRVVPQMARKGFLFVGMGVDEQNTDIWDVKKRTDSSAELMQMADKAEIDLLHKIDDLCHRGGDGVTRPAVRMEMFEMKDHPYFVGAQFHPEYLSHPLTPSPPFFGLLLAATGQLSSYFSGSRSPALQVVEEEGSSSDSLLKSTSSNGSDQIGEILDKLKLEGNARPGTQRLATFH