lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' piwil4. Piwil2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded. Required for piwil4/miwi2 nuclear localization and association with secondary piRNAs antisense.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Sequence:
MDPKKPCFPGLPGATRIPWLQQQAWGRGLRSDEPAIGRARGLMFATDGSASLGRARGFTTAGDTLLMQYGRGVPFPVSDPSIGFARGIPMPTSEDGGINRPRGWLLSTADPTVGVARGEPLLGLGPHLGQATPGQLAKQDLPEEMPSLQAEEEVVAKQVDMSTQGQGSSLVSMFRGMGIDPSKTWGRGGLPVGRGVFGAELQPQTAPVGAVAVAGPGGDRFPEDMMGQGNSFLGRGVPSQMVGMGRASMHPLGAGRGPTVPPTLPPSLHKEAHMTPGCSLTKGELKMEATCETLHKTGTKGTPLPIGSNHITIHCRNEAVYQYHVTFTPNVESMGMRFGMMKDHRPTTGEVVAFDGSILYLPVKMEEVVHLKSVRRTDNQEVDIKVQMTKILPPNSDLCIPFYNVVLRRVMKILGLKLVGRNHYDPKSAVILGKHRLQVWPGYSTCIKHTDGGLYLQVDVSHKVLRNDSVLDCMNVIYQQSRESFQDECTKELIGSIVITRYNNRTYRIDDIEWGKSPKDTFTMADGSTTTFVEYYSKNYGITIKEMDQPMLIHRPKERSKPGGKQVITGEILLLPELSFTTGIPDKMRKDFRAMKDLTMHINVSSEQHTHSLKQLLKNINTNPEAQTELARWGLEISQDILVTIGRILPLETICLQSVSFVTGADVSWSREVIRDASISCIPMNCWAIFYPRRCAEQAEELVSCFGKVAGPMGLRLDRPIRVELKDDRTETYVKSIHSQLTSEPNVQLVVCIMTGNRDDLYSAIKKLCCVQSPVPSQAINVRTISQPQKLRSVAQKILLQMNCKLGGELWTVNVPLKHLMVIGVDVHHDTSKKNRSVMGFVASLNSLLTRWYSRVTFQMPNEEIINGFRVCLLAALQKYYGVNHNFPEKIVVYRDGVSDGQLKTVELYEIPQLLKCFETFPNYEPKLAFIVVQKRVSTNLYSCSGDRFGTPPPGTVLDHTVTNREWVDFYLMAHHVRQGCGLPTRNISVYNTANLSPDHLQRLTFKMCHMYWNWPGTIRVPAPCKYAHKLAFLSGQYLHSEPAIQLADKLYFL
The following text describes a protein:
Function:
Heterodimer: has no cytolytic activity, but retains most of the alpha-cobratoxin capacity to compete with alpha-bungarotoxin for binding to Torpedo and alpha-7/CHRNA7 nicotinic acetylcholine receptors (nAChRs) as well as to Lymnea stagnalis acetylcholine-binding protein; Monomer: shows cytolytic activity. Exhibits concentration-dependent growth inhibitory effects in the lung cell lines A549 (IC(50)=1.22 ug/ml) and NL20 (IC(50)=2.76 ug/ml), in the prostate cell lines PC-3 (IC(50)=4.46 ug/ml) and RWPE-1 (IC(50)=0.65 ug/ml), and in the breast cell lines MCF-7 (IC(50)=12.23 ug/ml) and 184B5 (IC(50)=2.83 ug/ml), with high selectivity for the lung cancer cell line A549 (selectivity index=2.26). Induces primarily necrosis in the A549 cell line, and mainly late apoptosis in the MCF-7 and PC-3 cell lines.
Miscellaneous:
MISCELLANEOUS: Is classified as a S-type cytotoxin, since a serine residue stands at position 28 (Ser-29 in standard classification).
Subcellular Localization:
Secreted. Target cell membrane.
Sequence:
LKCNKLIPLAYKTCPAGKNLCYKMFMVSNKTVPVKRGCIDACPKNSLLVKYVCCNTDRCN
The following text describes a protein:
Function:
Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
Subcellular Localization:
Secreted.
Sequence:
MPSRLNVFWLCAAALAALLRCAPAAPVDGAFTDNPAGDTSGEEWETERPADPLIALLKVVLEVIKTHRQEFEAEFHIRYDVLAQYNIPSLPADCPSTNFSMEALLHRLLQGLPVYTALLKYVEKEEPKSQIPSRFRQNSELLKQRITGKMRHAVQVTPLTSSQEQQLLRDLDSSDTFHRKMTAHSILYQLRSFLVDCKNAINKKEKLRESRANRAMTPVTLYYQS
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MASSDNDDQGYSDFDEEEDPIELESDDDMATLLAARRQRYKVLTEGALRALQDDCIAGVADLIQVPPAIAAIVLRHCHWSALVVQEKWFSDEQGLRAAVGLLPPSDGDAVAEPKRKRKGKKLTCDLCFDNHPPGQMKSAGCGHLYCRVCWRGYIRAAVEDGARCLSLRCPDPSCSAAVLRDLVDDVADEEDKQRYAGFALRSYVEESKTMRWCPAPGCGLAMEYLGGESLSEQLDVVCDCGHGFCIVCAEESHRPVPCRTVREWAAKNSSESESTNWVMANTKLCPKCRRPIEKNTGCNHMTCRDPCRHQFCWICLADYHGGHTCNRYEVDEIDARQAYARASLDRYMHYYERWVAHEHSRVRASEDMFELESAREGYLEGAAADEAQRQLGFLIDAYRQILEGRRMLRWTYAYGYFADRDKLNLLECLQGEAEGSLERLHKMAEAERTASENYYAADGGVSSYFDRLAKLTKQTHDYFESMAEAFQTDLD
The following text describes a protein:
Function:
Essential protein involved in the second catalytic step of pre-mRNA splicing. Involved in the selection of 3'-type splice sites; this selection could be done via a 3'-splice site-binding factor, PRP16.
Miscellaneous:
MISCELLANEOUS: Present with 1490 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The CCHC-type zinc finger probably plays a role in the ability of SLU7 to bypass the requirement for PRP18.
Sequence:
MNNNSRNNENRSTINRNKRQLQQAKEKNENIHIPRYIRNQPWYYKDTPKEQEGKKPGNDDTSTAEGGEKSDYLVHHRQKAKGGALDIDNNSEPKIGMGIKDEFKLIRPQKMSVRDSHSLSFCRNCGEAGHKEKDCMEKPRKMQKLVPDLNSQKNNGTVLVRATDDDWDSRKDRWYGYSGKEYNELISKWERDKRNKIKGKDKSQTDETLWDTDEEIELMKLELYKDSVGSLKKDDADNSQLYRTSTRLREDKAAYLNDINSTESNYDPKSRLYKTETLGAVDEKSKMFRRHLTGEGLKLNELNQFARSHAKEMGIRDEIEDKEKVQHVLVANPTKYEYLKKKREQEETKQPKIVSIGDLEARKVDGTKQSEEQRNHLKDLYG
The following text describes a protein:
Function:
Pectin methylesterase (PME) inhibitor involved in the maintenance of cell wall integrity in response to necrotrophic pathogens. Modulates PME activity and pectin methylesterification during infection by Botrytis cinerea and contributes to resistance against the pathogen.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MKFLVSLVIFSLFLNGFATAQTLIQDSCKKAFAKDPQLSYDFCVNSLTQDPQSKAATTLESLVLASTKTAAAKITNLKGIVAQDLKDQRYQDIVEDLKLCLGFYNDANDDLTTALANIKSRDYQGANINLSAALDVPGNCEDDFKEAKKTSPITNENSILFKTILIPLAFTNML
The following text describes a protein:
Function:
Responsible for specific up-regulation of the translocon genes TOC33 and TOC75 in leaves. Involved in the general chloroplast protein import pathway regulation, including protein import and protein translation efficiencies.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
Subcellular Localization:
Plastid, chloroplast. Nucleus.
Sequence:
MSACLSSGGGGAAAYSFELEKVKSPPPSSSTTTTRATSPSSTISESSNSPLAISTRKPRTQRKRPNQTYNEAATLLSTAYPNIFSSNLSSKQKTHSSSNSHFYGPLLSDNDDASDLLLPYESIEEPDFLFHPTIQTKTEFFSDQKEVNSGGDCYGGEIEKFDFSDEFDAESILDEDIEEGIDSIMGTVVESNSNSGIYESRVPGMINRGGRSSSNRIGKLEQMMMINSWNRSSNGFNFPLGLGLRSALRENDDTKLWKIHTVDFEQISPRIQTVKTETAISTVDEEKSDGKKVVISGEKSNKKKKKKKMTVTTTLITESKSLEDTEETSLKRTGPLLKLDYDGVLEAWSDKTSPFPDEIQGSEAVDVNARLAQIDLFGDSGMREASVLRYKEKRRTRLFSKKIRYQVRKLNADQRPRMKGRFVRRPNESTPSGQR
The following text describes a protein:
Function:
Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
Subcellular Localization:
Bacterial flagellum basal body.
Sequence:
MDFSKAFGLVYKALDYRSLRQDMIASNIANVDTPFYRPKDLDFESVLAKKKAEIFENQSSKVLPLAHTNPRHLDFENSAKDGASLFFRDGHLAKNDGNSVDLDIETSEMGKNSTMYLALSSALKKYRGVINYAIDSSKNL
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MLSVHEVTTAYQGLVAISAVSIEVEKGEIVCVAGANGAGKSTLLKSIAGAERPRSGTVTFDGKRLDGMAQHHITATGIAYVPENRRLFPRLSVRDNLRLGSYLYRGEANREGPLDLVFNLFPRLQERLEQRAETLSGGEQQMLAIGRALMTRPRLLMLDEPSQGIMPKLVDEIFQAVLRIRDAGMTVLIVEQRMAECLEIADRAYILQTGRVLMQGAASEIKGNPDVRKAYLGL
The following text describes a protein:
Function:
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
Subcellular Localization:
Cytoplasm.
Domain:
The PRC barrel domain binds ribosomal protein uS19.
Sequence:
MLWVVMDDLLYIGALGAPFGVRGQIRLHSISSHPEHLIRHLRTVFIGPKRVPHQVSRLYMHKPGLLIIQLQTITDRDAAADLRGEEVYIAAADAAPLAADEFFYHDVIGMQAVTDSGEDIGEVRDILETGAGEIVVITRRGRPDALVPMVRDFIVAIDVGERRLVIRPIAGLLD
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MDKQEVKAFFDKTIAENEDLSVGVVAIMTLMKIIEKYQDNTVQGLDENLKLGILAIKTSDYPVTAINSGCELFMRFITLAKLDYNSFEQCRNVMLERGNIFLNRLKQCRAKIVKLATKFIADGSKVLTHSRSRVVLQTLIEASRQGKQFEIYVTKSAPDNSGDVMCKNLTSVGIPCTLILDSAIGYVMEQVDFVMVGAEGVVESGGIVNKVGSYTMAVCAKEMKKPFYVLTESFKFSRLFPLNQGDLPPEYKYSASARQLDERDFKKIHPLVDYTPPFYITLLFTDLGILTPSAVSDELIKLYL
The following text describes a protein:
Function:
Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
The following text describes a protein:
Function:
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion matrix. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Sequence:
MLKFLTPTAYASHHVTPATRFRSTPVKNLLFKQLTLLTGWNRSSYELGRRSFSSDLDSDTKSSTTTVSAKPHLDDCLTVIALPLPHKPLIPGFYMPIYVKDPKVLAALQESRRQQAPYAGAFLLKDDASSDSSSSSETENILEKLKGKELINRIHEVGTLAQISSIQGEQVILIGHRQLRITEMVSESEDPLTVKVDHLKDKPYDKDDDVIKATYFQVMSTLRDVLKTTSLWRDHVRTYTQACSLHIWHCLRHIGEFNYPKLADFGAGISGANKHQNQGVLEELDVHKRLELTLELVKKEVEINKIQESIAKAVEEKFSGDRRRIILKEQINAIKKELGGETDSKSALSEKFRGRIDPIKDKIPGHVLKVIEEELKKLQLLETSSSEFDVTCNYLDWLTVLPWGNFSDENFNVLRAEKILDEDHYGLSDVKERILEFIAVGGLRGTSQGKIICLSGPTGVGKTSIGRSIARALDRKFFRFSVGGLSDVAEIKGHRRTYIGAMPGKMVQCLKNVGTENPLVLIDEIDKLGVRGHHGDPASAMLELLDPEQNANFLDHYLDVPIDLSKVLFVCTANVTDTIPGPLLDRMEVITLSGYITDEKMHIARDYLEKTARRDCGIKPEQVDVSDAAFLSLIEHYCREAGVRNLQKQIEKIFRKIALKLVRKAASTEVPRISDDVTTDTEETKSLAKTDLESPETSAEGSTVLTDELATGDPTESTTEQSGEVAETVEKYMIDESNLSDYVGKPVFQEEKIYEQTPVGVVMGLAWTSMGGSTLYIETTFVEEGEGKGGLHITGRLGDVMKESAEIAHTVARRIMLEKEPENKLFANSKLHLHVPAGATPKDGPSAGCTMITSLLSLALKKPVRKDLAMTGEVTLTGRILAIGGVKEKTIAARRSQVKVIIFPEANRRDFDELARNVKEGLEVHFVDEYEQIFELAFGYDH
The following text describes a protein:
Function:
Probable DNA polymerase.
Sequence:
MIGCHCHTDRSNIRLLDSTNSVKELLKTAVKMEYKGLAITDHEVLSAHLDAIRTVREMKKKGDMPEDFKLILGNEAYLVDSLEEVRDNYKSGVTKFPHFLMLAMDPKGHEQLRILSSQAWENSFYTGTMERVPTVKKDVEELLSKDPGHIIATTACLGSEVNIHLLKIKAFEETGDSQSIKQHKLKIHEFITWCIEVFGKDKFFIELQPALSEEQIYCNKKLIDIANGYDLQMIVTTDAHYLRPEDRAIHQAFLNAKDGEREVDSFYEACFVQNVDEIHERMDYIDKEVIDQAIKNTMLIGEMIEDYTIEHEPIIPKMELPNFKLRHLFKPAYDQYEYIKKMSESADEQDRYLLKLIEDGFEEKLKTSELTREAFHKILNRINVELGELWEISQKLNQSMSSYYITVREIINIIWDDECGGDSLVGAARGSAAGYLVNYLLDNTQINPMQYDLPHWRHIHKSRPDLPDIDIDTEGSKRQKILKALRERFGDKRVLQIATFGTEGSKSALQTACRGLGIDNDISQYLSGMIPFERGSNWPLKHCFYGDKETGRKPIKEFIREVEQYPNLKETALKIEGLTNKRSSHAAGVIIFNDEYTKSNAMMKTPKGAYITQFNMGDSEAMGSVKFDLLTIEALDKIRVTLDQLIENNEIEWQGSLKETYNKYIHPDVIEYEDDKLWEMAGNGEIMDLFQFSTEVGHQSVVKVKPKNLLEAAVTNSLMRLMSDGEEQPVDTYVKYKNNLNKWYEEMTRYGLSEKEIRVMERHLKDIYGVADTQEVVMQMVMDKDIANFDIKESNYLRKSIAKKKEDVLKEVEELFFKKGKEIGTSDNLLNYVWNVQFKRQFGYSFSLLHTLAYSIIALQELNLNYRYNPLYWNTACLTVNSGGIDTEDTKDNKKTAATNYGKVASAIGNIRQRGIKIDLPDINKADFGFRTDINNNSILFGLKGMNGIGDDVIHHIVLNRPYSDFNDFIERMFKSGIIKKGQVIQLIKGGCFDSFGNRQEIMKAFISLISEPKSKLTLSNLKMLIENNIVPSEFAQEVRFFRFKDYISKKVYKTLKSPKDKLFLLDDVSASFYNQHFSEDSVVDMLNGQLVISEKAFKKEYDNKMSNIKSWITTEEPLKKLNDCLLIKEWEKYADGSLGKWEMDSLSYYYNDHELSGVNFAKYDIADFYKLPAEPVKGKPYQWRGKTLYEYETTRIIGTVLDRDKNKHAITLLTPTGVVTVKQWSGSFSHYNKQISRSIGGGKKEVIEKSWYTRGTLLMFTGFRRGNNFIPKVYKDSIYNHTVCRIDFVDNEGSMSLTTKRAEI
The following text describes a protein:
Function:
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
Subcellular Localization:
Cytoplasm.
Sequence:
MEKEGEILLKPGQQIKPHVPNEVVHQLVFKLYNLEVASVKELNSYDDKNFHVTVESDSALPDIHDACPHGYVLKVLNSLDSKAYNLIDAQNEMMLYLAKTGLPCPRPVKNVDGKSMSLEHLKDAQNQSTDQYIVRLLSFVPGKILFSVPYTKELFFQVGELVAKTDLALMGFKHNGLKGVDRIWSLIAVPKLVDFVYVIADEQKHSISMEVIENFKSNVIPFLQELESGPIHGDFNEQNILVEADKEDPEKYSISGMLDFGDVHFGYYLFDIAIAICYMMIECKSMDMLDAPGHVLAGYNRVRPIPQKEFDLLKDCISARFSQSLVLGAYSYSQNPDPYLLTTAQRGWQCLKTLWDCPKGELYKRWNEIINSYDNN
The following text describes a protein:
Function:
Component of the U4/U5/U6 snRNP, binding principally to the u5 snRNP. It is not absolutely required for the second step of pre-mRNA splicing at low temperatures but is required at higher temperatures. It may stabilize a particular conformation of the U5 snRNP or orient the U5 snRNP within the U4/U5/U6 snRNP or within the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MDLDLASILKGEISKKKKELANSKGVQPPCTEKFQPHESANIDETPRQVEQESTDEENLSDNQSDDIRTTISKLENRPERIQEAIAQDKTISVIIDPSQIGSTEGKPLLSMKCNLYIHEILSRWKASLEAYHPELFLDTKKALFPLLLQLRRNQLAPDLLISLATVLYHLQQPKEINLAVQSYMKLSIGNVAWPIGVTSVGIHARSAHSKIQGGRNAANIMIDERTRLWITSIKRLITFEEWYTSNHDSLA
The following text describes a protein:
Function:
May be required for efficient assembly of the mitochondrial complex I.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MDMMMMSTRLIHLSRHFPQYGFRCHPSGLISSARMQYNINNGLAHMGKQMPNTSTHTTRIHPASFSSDLASRKYSLIYAFPLIRGLRALSRLKLLQTGITVVLLPTVYYLHLQGQASVLVLNRSIGIALFAGVMLYSISHFVRRVVGMMYLDSTQTILKVSHLSFWGHRRDIYVPVSDVVTLGDSGDSRGESILRLKRYSTSNTMYFSTRLGRVVDRHAFGKVFGSLS
The following text describes a protein:
Function:
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAEARKRRELLPLIYHHLLQAGYVRAAREVKEQSGQKSFLTQPVTLLDIYTHWQQTSELGQKQKAEDDETLQAKKSRVSDPVSSSESSDQEKEEEAATERAKATPRPTPVNSATAALPSKVKEKGKTKTANKTVNSVSHPGSGKTVVHLLSGKSPKKSAEPLANTVLASETEEEGNAQALGPTAKSGTVSAGQGSSSSEDSSISSDETDVEVKSPAKPAQAKASAAPAKDPPARTAPGPTKLGNVAPTPAKPARAAAAAAAAAVAAAAAAAAEESESSEEDSDSEDEAPAGLPSQVKASGKGPHVRADSVSAKGISGKGPILATPGKTGPAATQAKAERPEKDSETSSEDDSDSEDEMPVTVNTPQARTSGKSPRARGTSAPAKESSQKGAPAVTPGKARPVAAQAGKPEAKSSEESESDSGETPAAATLTTSPAKVKPLGKSSQVRPVSTVTPGSSGKGANLPCPGKVGSAALRVQMVKKEDVSESSSAELDSDGPGSPAKAKASLALPQKVRPVATQVKTDRGKGHSGSSEESSDSEEEAAPAASAAQAKPALEKQMKASSRKGTPASATGASTSSHCKAGAVTSSASLSSPALAKGTQRSDVDSSSESESEGAAPSTPRVQGKSGGKGLQGKAALGQGVAPVHTQKTGPSVKAMAQEDSESLEEDSSSEEEDETPAQATPLGRLPQAKANPPPTKTPPASASGKAVAAPTKGKPPVPNSTVSARGQRSVPAAGKAGAPATQAQKGPVAGTGEDSESSSKEESDSEEETPAQIKPVGKTSQVRAASAPAKESPKKGAHPGTPGKTGSSATQAQPGKTEDSDSSSEESDSDTEMPSAQAIKSPPVSVNRNSSPAVPAPTPEGVQAVNTTKKASGTTAQSSSSESEDGDEDLIPATQPSTYALRTSVTTPAALSRAASQPSKSEQSSRMPKGKKAKAAASAQTSSAVETLPMMPPQSAPIQPKATNKLGKSKLPEKQQLAPGYPKAPRSSEDSSDTSSEDEEDAKRPQMPKSAHRLDPDPSQKETVVEETPTESSEDEMVAPSQSLLSGYMTPGLTVANSQASKATPRPDSNSLASSAPATKDNPDGKQKSKSQHAADTALPKTGRKEASSGSTPQKPKKLKKSTSSSPAPTQTLPNSITQRLLEQAWPLSEAQVQASVVKVLTELLEQERLKATEAIKESGKKSQKRKLSGDLEAGAPKNKKKKEQPVPRASAVSPEKAPMTSKAKSKLDKGSAGGKGKGSPGPQGAKEKPDGELLGIKLESGEQSDPKSKSKKKKSLKKKKDKEKKEKKKGKKSLAKDSASPIQKKKKKKKKSAEPAV
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MLGRRIFSPAPNRGFILCNLIQSNNSTRRGFSDNRKFNERNSEASSNVGFQRRVRSNIPSYLSASVEEGDIYSPNDLLFETVKAKNQAKFYEPVREDCFKTVNENPMNYWKNPVILSRFVTELGRIKPRGDTGLTAKNQRLLSRAIRRARAAGIMPTKYKSVYSEN
The following text describes a protein:
Function:
Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPPSPLDDRIVVALPRPIRPQELRLRLDTSYLETTVGKTTVISSTTVVKIQAATLSYMPSSSGSTRSLTCGCSSASCCTVTTYEKDGQVSASSPNLHSGSGYGVQQGSVHGSAPSLTSSLTRGGMRVIHPNELAKKLTHCPLGHPIGPVPVIIDCRPFLEFNKSHIRGAMHINCSDKISRRRLQQGKITVLDLISCRQSKDSFKGIFSKELVVYDESTVDPGRLTPSQPLHVVLESLRREGKDPIVLKGGLSGFRQTHADLCEHSLHLDEGQDGSGAMGLSGALPHSLPSTPDIENAELTAVLPFLYLGNERDAQDLELLQRLDIGFVLNVTTHLPLYHYDIARFCYKRLPATDSNKQNLRQYFEEAFEFIEEAHQAGRGLLIHCQAGVSRSATIVIAYLMKHTWMTMTDAYKFVKSRRPIISPNLNFMGQLLEFEEDLNNGITPRILTPRLTGLETLV
The following text describes a protein:
Function:
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for fusion of late endosomes with lysosomes and homotypic lysosomal fusion.
Subcellular Localization:
Endosome membrane; Single-pass membrane protein.
Sequence:
MNNNNNFNSNFNSNRISSTQPYLSDDARNALFEGKDRKWGNNNNNNYDTLSNQDVFEKQKRDMEEQDKMLDALSGSISRVKDTAITINKTAQEQTDMLDELDVHVDSTSARMRNTTKNLITLTQQSKTTGYCSAICFLLLVLLVIIILASVL
The following text describes a protein:
Function:
Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol.
Sequence:
MGVEVDVEFCGTCGYFKKFEELAQHIKAKHPDIELNGHEGRRATFEVKVNGTLVHSKLTTLAYPDYDDLSAIIDEVAQGKEPRSCKQQPITSCIIA
The following text describes a protein:
Function:
Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2.
Subcellular Localization:
Nucleus.
Sequence:
MAELGKKYCVYCLAEVSPLRFRCTECQDIELCPECFSAGAEIGHHRRYHGYQLVDGGRFTLWGPEAEGGWTSREEQLLLDAIEQFGFGNWEDMAAHVGASRTPQEVMEHYVSMYIHGNLGKACIPDTIPNRVTDHTCPSGGPLSPSLTTPLPPLDISVAEQQQLGYMPLRDDYEIEYDQDAETLISGLSVNYDDDDVEIELKRAHVDMYVRKLKERQRRKNIARDYNLVPAFLGKDKKEKEKAAKRKVTKEEKELRLKLRPLYQFMSCKEFDDLFENMHKEKMLRAKIRELQRYRRNGITKMEESAEYEAARHKREKRKENRNTGGSKRGKEDGKDGEFAAIEHLPGFELLSDREKVLCSSLNLSPARYVTVKTIIIKDHLQKRQGVPAKSRLPGYLDKVLKKRILNFLTESGWISRDAS
The following text describes a protein:
Function:
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis.
Sequence:
MQTFVKGKRVGYWLSEKKIKKLNFQTFVDLCRKQGIEMIQLDLSQPIESQGPFDVIIHKLTDHIVDADQNVTESLLLVQGVQDYIDAHPETVILDPLPAIRTLLDRCKSYKLIHKLEHSMEDDRICSPPFMVLKTECGFETLEQLHKHGITFPFICKPQVAHGTNSHEMAIIFSEEDLKDIKPPCVLQSFINHNAVLYKVFVVGEAYSVVQRPSIRNFPSGPTDRRAISFNSHHVSKPESSSHLTCRDNMVGQSWKPSNEVIQKISRKLHQALGISLFGIDIIINNQTGQHAVIDINAFPGYEGVPEFFDDLLSHISSVLQGQVCNGVACGHLRVNGTAQSQTVHCGMLGNDSSWLMDSEGIKKGPHQGLSCCGGCMTPNFHQHTRSSLTAETSSQ
The following text describes a protein:
Function:
Transcription factor that binds to the 5'- RRYGCCGT-3' consensus core sequence. Central longevity regulator. Negative regulator of leaf senescence. Modulates cellular H(2)O(2) levels and enhances tolerance to various abiotic stresses through the regulation of DREB2A.
Subcellular Localization:
Nucleus.
Domain:
The NAC domain includes a DNA-binding domain and a dimerization domain.
Sequence:
MSGEGNLGKDHEEENEAPLPGFRFHPTDEELLGYYLRRKVENKTIKLELIKQIDIYKYDPWDLPRVSSVGEKEWYFFCMRGRKYRNSVRPNRVTGSGFWKATGIDKPVYSNLDCVGLKKSLVYYLGSAGKGTKTDWMMHEFRLPSTTKTDSPAQQAEVWTLCRIFKRVTSQRNPTILPPNRKPVITLTDTCSKTSSLDSDHTSHRTVDSMSHEPPLPQPQNPYWNQHIVGFNQPTYTGNDNNLLMSFWNGNGGDFIGDSASWDELRSVIDGNTKP
The following text describes a protein:
Function:
Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
Sequence:
MQSQQFTSNALAKQYTQSFGIVAALTKNGVIGINGSLPWESLTQDRDHFINLTRGKVLILGRKTFVDEDPSGGHVDHARACIVVSSTMYYSRSHGSTLVKVARSLDEALVMANKLNTSSGITKTRNSSIDCWVAGGERLYKDALQHPCAAEVHLTQVDITISTDMLATKDEVAYFPVDYLNNYGFQEVSKREDGICVFCVYKRQTQRVREIECW