lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1-sulfonate (DHPS). Metabolite profiling studies showed that the enzyme also catalyzes in vitro the NADH-dependent reduction of succinic semialdehyde (SSA) to 4-hydroxybutyrate (GHB), and that it could be involved in the metabolism of SSA, and other potentially toxic intermediates that may accumulate under stress conditions. However, the enzyme exhibits a 42,000-fold greater catalytic efficiency for the reduction of SLA over SSA (Ref.6). Shows no detectable activity on the analogous glycolytic intermediate glyceraldehyde-3-phosphate (Ref.6).
Sequence:
MAAIAFIGLGQMGSPMASNLLQQGHQLRVFDVNAEAVRHLVDKGATPAANPAQAAKDAEFIITMLPNGDLVRNVLFGENGVCEGLSTDALVIDMSTIHPLQTDKLIADMQAKGFSMMDVPVGRTSANAITGTLLLLAGGTAEQVERATPILMAMGSELINAGGPGMGIRVKLINNYMSIALNALSAEAAVLCEALNLPFDVAVKVMSGTAAGKGHFTTSWPNKVLSGDLSPAFMIDLAHKDLGIALDVANQLHVPMPLGAASREVYSQARAAGRGRQDWSAILEQVRVSAGMTAKVKM
The following text describes a protein:
Function:
Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity).
Subcellular Localization:
Nucleus. Nucleus, nucleolus.
Sequence:
MASSAASSVRPPRPKKEPQALIIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPRPPPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLEAEFQKRLERNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQSEASSETQEQPSSGSEEASGTEDEEEDAPSFITGR
The following text describes a protein:
Function:
Aminopeptidase which specifically catalyzes the removal of glutamic acid or aspartic acid residues from the N-terminus of peptides. May play a role in the final step of host hemoglobin catabolism, by cleaving hemoglobin-derived oligopeptides in the cytoplasm (Probable).
Subcellular Localization:
Cytoplasm.
Sequence:
MDKKAREYAQDALKFIQRSGSNFLACKNLKERLENNGFINLSEGETWNLNKNEGYVLCKENRNICGFFVGKNFNIDTGSILISIGHIDSCALKISPNNNVIKKKIHQINVECYGSGLWHTWFDRSLGLSGQVLYKKGNKLVEKLIQINKSVLFLPSLAIHLQNRTRYDFSVKINYENHIKPIISTTLFNQLNKCKRNNVHHDTILTTDTKFSHKENSQNKRDDQMCHSFNDKDVSNHNLDKNTIEHLTNQQNEEKNKHTKDNPNSKDIVEHINTDNSYPLLYLLSKELNCKEEDILDFELCLMDTQEPCFTGVYEEFIEGARFDNLLGSFCVFEGFIELVNSIKNHTSNENTNHTNNITNDINDNIHNNLYISIGYDHEEIGSLSEVGARSYCTKNFIDRIISSVFKKEIHEKNLSVQEIYGNLVNRSFILNVDMAHCSHPNYPETVQDNHQLFFHEGIAIKYNTNKNYVTSPLHASLIKRTFELYYNKYKQQIKYQNFMVKNDTPCGSTVGSMVAANLSMPGIDIGIPQLAMHSIREIAAVHDVFFLIKGVFAFYTYYNQVLSTCVHDK
The following text describes a protein:
Function:
Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.
Sequence:
MGDEAQRGSKSVPKPAPKQVYCDVCDVYLSSAALVDTHKNGRKHTNLVKVKADKASVQKKTIFVRGFDKSLITCADLEQLFSQFGEIRNIYIDKEKNCYALVEFETDASVAKVLNQTEPLTLNDKTLKVKPKSSPKKVEKKPDHTNPSSSPVSPGSKKRKRGTSQSELSNFVTSELFKGLNSSNTVSTKFFIYSQCFGKAVEEQISVLMEHLGLSKDDLQLRDLICQLLAGVFQEFFPTCSVMPYGSSANGLGWKGSDLDLCLLLDNNPSEEDLSKDGVKQCADELGIVVKALKDLVPGCAHVVPVFSAKCPVVKFVHQPSGVSCDLTINNRLCINKWLLLSSSTTPAHENCNCEQAKFIDGWDCSYFDDVTRVSSSENSCDIVQLLTAFFDFYGNRFDYGNCVVNIRTGQHCTKLAIQEELQEVMRSRTKGDNAMSLPKIVEFDLTDFCVQDPFELSHNVTRSLSTMALKDLIKYMMTAREVCKRICPLEYFRDTKGIIALLTTSCGETRARKLEQCSFDVPLAVGKDSPDFTSEDDLLRDVLRFLTEDLKVHYEVEKTEITSKELQDKDGLLNEVLTSSDSTLDNPERFPSSKVECIEKFPDSILLIATCTAWENTWTHSRRQRRRIIAERDGSQEKSHLQGESPSVDGDVSPSSSRGTALPVLVFRLVYKHKADQDRPRASFYLHHVRSQGFGTFGNFYALFKKKVVGMYYRRYEKDP
The following text describes a protein:
Function:
Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. Probably in association with ATPase cdc-48.1 or/and cdc-48.2, regulates the centrosomal levels of kinase air-1 levels during mitotic progression by promoting air-1 removal from centrosomes in prophase. Also, regulates spindle orientation in the one-cell embryo by controlling centration and rotation of the pronuclei-centrosome complex in prophase.
Subcellular Localization:
Cytoplasm, perinuclear region. Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with cdc-48.1 to the perinuclear region in spermatocytes. Nuclear localization is cdc-48-dependent. During embryonic mitotic metaphase, telophase and to a certain extent prophase, localizes to centrosomes.
Sequence:
MSRNIRTFRDIGNNDDGGPDSDDSGADAAERGAPQEFYAGSGQAVQGPRGAAARGPDSEAHIRRILQAAEVVQPEGGEAPRGRPSGRETISLTLHLWSDGLSIEDGPLMSRQDPRTIEFLESVGKGEIPPSLVQQYPGKEIDFKVNRHHEEYVAPKMKPFGGSGVRLGNVVPTVLGQSSSSATTAGTSSATTDHNPDHTAENEAKQLEDAKKELSTNMNEPTTNIQIRLPNNQRLVGIFNHSHTLEAVRTFICTARPDMIYAPFQMMAAYPPKPFEDESQTLKDANVLNSVVAVKILPTTN
The following text describes a protein:
Function:
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MGPSFTVSVCGYEAVVEALHNEDLNGRPDSAARRERTFGKRLGLMFIDGDFFREQRRFTLRHLRDLGFGRTSAEDMIQDEIREMIRVIGDQSSSDPSGVVDFKNGIFNRSVLNILWALIGGERFHRDDARLTNLLNMVDFFNRNFKPQTANVAVPGFLLRMFPSLRKILGIRNDIFEPLQNFIRTVIEEHARDRDDVPRDFIDVYLKEMEKQQMDLPEDQKQSTSFHVEQLIALVIDLFLAGAETSSNAIGFALLYMVHYPEVQRKMQAELDRICGDALPSLAHRPSLVYTEAVLIESLRLANVAPLTLMHCASKDTQLGGFNIPKASLVLINLYSVNMDETYWTDPQVFRPERHLDSDGSLLKKSERFMPFGLGKRQCLGEPLARNSFFLFTAALVKAFQLEAVPARPLPTLDPLTGVTNGYQGFQAIVTPRI
The following text describes a protein:
Function:
MFS-type efflux pump; part of the gene cluster that mediates the biosynthesis of mannosylerythritol lipids (MELs), surface-active substances that enhance the availability of water-insoluble substrates. Mannosylerythritol lipid production is responsible for hemolytic activity of Ustilago maydis. MMF1 is directly involved in the secretion of MELs.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MADEKRTSIEEPGTPMSYSTAASPELLSSSNNASALPAYPSSQTKQDKESLSHDQAVRVEPESSTPLTDSVEDNESGAKVKKDLHFWIIFSALMLIAFVAALDMTMISTALPAITANLPPSTIAANWITSAFLLPMVASQPIFGGLSCSIGRKWSINSALVIFLVGSVVCATAKTFLVLVIGRGIQGLGGGGIHSMCEIIMSDLTTLRERGLFFGVIALVFAVAGFAAPVLGGVFSEHSWPWIFWINLPIGAISLVLLIIFLNIRVPLLTGKEKWQKLDLVGNAVLFGSVTAILIAVTEGGIKYRWSAWQIWVPLVVGLLGIMLFLVIEWVPNRIAPKPVFPLDLFRNRTASVAYVQTFVHGVIFYGVIYMVPIYFQAIKDRTPLQSAIWSFPLSAPSFPFAMGAGVLISITGKYKLLIFCGWMLMAAGIGWMTHWHVGTSKFEWAFSQVILGAGLGIMFPITLPPIQAALPASRLESATAAYAFTRTFGAVWGITAATTIFSTQAAKNLRPYYDQLNPLGLSDFTVVAFSEQLRNLPQPIQGVVKGVYADAISDSYWLFVPLAIIGFFTTFGMKELPLPDFIKSEAKLEQKQDVTPALKSSAAHAVVNVKTEVPSTLP
The following text describes a protein:
Function:
May play a role in ciliogenesis. In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Extensive colocalization with CBY1 at mother centrioles.
Domain:
The BAR-like domain displays limited similarity to other BAR domains.
Sequence:
MNVVLSRDSQVRAMENTVTNAERYFGQFCSLLASYTRKTARLRDKADQLVKQLIDFANTENPELRATIRDFAEDLAKVQDYRQAEVERLEAKVISPLKLYGAQIKQTRADIKKCKRVQNNEIKQLEKLEKLRQKSPSDRQMISQAETSAQRASVDTNRSTLHLVETVDAFQEQKLKDLRRIFSDFVTIEMVFHAKAVEVYSSAFQTLENYDLERDLQDFRAKTRGIYGHGEARPLTDTNPAPSVPWPLASQSAQSTMARQGKEAGGEEDSETDSVEEIPLEDLKGQQQGPRD
The following text describes a protein:
Function:
Required for the biosynthesis of putrescine. Catalyzes the first step of polyamine (PA) biosynthesis to produce putrescine from arginine. Is a major contributor to basal arginine decarboxylase (ADC) activity and putrescine biosynthesis. Accumulation of putrescine plays a positive role in salt stress tolerance. Accumulation of putrescine plays a positive role in freezing tolerance. Production of PA is essential for normal seed development. Controls PA homeostasis which is crucial for normal plant growth and development.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing ADC2 accumulate very high levels of putrescine and exhibit dwarfism and late-flowering phenotypes.
Subcellular Localization:
Plastid, chloroplast. Cytoplasm, cytosol. Note=Localizes mainly in the chloroplast.
Sequence:
MPALACVDTSFVPPAYAFSDTAGDVFIPASSPTSAAVVVDRWSPSLSSSLYRIDGWGAPYFIANSSGNISVRPHGSETLPHQDIDLLKIVKKVTGPKSSGGLGLQLPLIVRFPDVLKNRLECLQSAFDYAIKSQGYDSHYQGVYPVKCNQDRFVVEDIVKFGSSFRFGLEAGSKPEILLAMSCLCKGSPDAFLVCNGFKDAEYISLALLGRKLALNTVIVLEQEEELDLVIELSQKMNVRPVIGLRAKLRTKHSGHFGSTSGEKGKFGLTTTQIVRVVRKLRQSGMLDCLQLLHFHIGSQIPSTSLLSDGVAEAAQLYCELVRLGAHMKVIDIGGGLGIDYDGSKSGESDLSVAYSLEEYAEAVVASVRVVCDRSSVKHPVICSESGRAIVSHHSVLIFEAVSADKPMVHQATPGDIQFLLEGNEEARANYEDLYAAVMRGDHESCLLYVDQLKQRCVEGFKEGVLSIEQLASVDGLCEWVLKAIGASDPVHTYNINLSVFTSIPDLWGIDQLFPIVPIHKLDQRPGARGILSDLTCDSDGKINKFIGGESSLPLHELDKNGSGGRYFLGMFLGGAYEEALGGVHNLFGGPSVVRVSQSDGPHSFAVTRAVPGQSSADVLRAMQHEPELMFQTLKHRAEEMMHTKGGSEGENEEEEEDDEFNNVAASLDRSFHNMPYLATEQASPSNSLSAAISNLGFYYCDEDVYDYISA
The following text describes a protein:
Function:
Thiol dioxygenase that catalyzes the dioxygenation of 3-mercaptopropionate (3-MPA) to 3-sulfinopropionate (3-SPA). To a lesser extent (40-fold lower efficiency), is also able to oxidize cysteine to cysteine sulfinate (CSA). Cannot use N-acetyl-L-cysteine, homocysteine, and cysteamine as substrates. The physiological role of this enzyme is unclear.
Miscellaneous:
MISCELLANEOUS: Does not contain a cysteine-tyrosine cross-link observed in all mammalian cysteine dioxygenase (CDO) structures.
Sequence:
MSSILRLDRLRQFIGELATLLDSRPDESTLLAQAHPLLAELVHQDDWLPEDCARPDPQRYQQYLLHVDSRQRFSVVSFVWGPGQITPVHDHRVWGLIGMLRGAEYSQPYAFDAGGRPHPSGARRRLEPGEVEALSPRIGDVHQVSNAFSDRTSISIHVYGANIGAVRRAVFSAEGEEKPFISGYSNSRLPNIWDLSKENPA
The following text describes a protein:
Function:
Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Binds tungstate and molybdate (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MIKRLIVISILLIVGTVLCGCMEQENVGQQNSEAQEKIVLKIFHAGSLSVPFEEYEKMFEKEHPNVDVEREPAGSVACVRKIIDLGKKADILASADYSLIPQMMMPKYADWYVMFARNEIVLAYTDKSKYKDEINSTNWYKILQRPDVKIGFSNPNDDPCGYRTQMVLQLAELYYKDPTIYDNLVLKHSNIKVEENNGTYLILVPKELDVDTNKLFVRSKETDLLAPLEAGAFDYLFIYKSVANQHHLKYIELPKEINLGYYEYADTYKKVALKIIAKNKTINAKPIVYGMTVPTNAPHKKEAIEFVKFVLGHPEVLENNGQPAIIPAVAYGNVPEELKDLVKIEK
The following text describes a protein:
Function:
Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.
Sequence:
MTLELPTETTHLSDSLLAEFARHTTIDIDNNVASIAAQHNLAHRRLLELDETKHTNRAQIDQQVVNEFQSLFHDMTSNQIIVLSTYSELLTNDKNKAAKLVEMCVAAAKQIKGGMWNGKQLSSTVLERISVDGLTGAESDEEKHQQLASDILTVHFGLEMLPNLLASGNLHAQTATSQAYNASATVRHARRFVALYELISGDTVDSSRVCIKIPTTIAGLQAMRFLSSGGILDENNVGGPLLEGKIQVLATTVFAVEQGLAAAQAAGATYVAPYINALAAHFFDAENPSAEDKQKALDAGGRSISEIIYPLQRCLRRMRQQNNKIKTKVMAASFINAEEAIELCGLDHVTLGAGIVQALATTKLTDGIVETMHQASDKMRIAEEKELERYCATLAAIKDGEAQGCGGWLKQGHRSHARLEIVLTQDERCRYMLADALARFTSAEVKLRQLFVV
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Has DNA primase activity. Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL).
Subcellular Localization:
Mitochondrion.
Sequence:
MSALCWGRGAAGLKRALRPCGRPGLPGKEGTAGGVCGPRRSSSASPQEQDQDRRKDWGHVELLEVLQARVRQLQAESVSEVVVNRVDVARLPECGSGDGSLQPPRKVQMGAKDATPVPCGRWAKILEKDKRTQQMRMQRLKAKLQMPFQSGEFKALTRRLQVEPRLLSKQMAGCLEDCTRQAPESPWEEQLARLLQEAPGKLSLDVEQAPSGQHSQAQLSGQQQRLLAFFKCCLLTDQLPLAHHLLVVHHGQRQKRKLLTLDMYNAVMLGWARQGAFKELVYVLFMVKDAGLTPDLLSYAAALQCMGRQDQDAGTIERCLEQMSQEGLKLQALFTAVLLSEEDRATVLKAVHKVKPTFSLPPQLPPPVNTSKLLRDVYAKDGRVSYPKLHLPLKTLQCLFEKQLHMELASRVCVVSVEKPTLPSKEVKHARKTLKTLRDQWEKALCRALRETKNRLEREVYEGRFSLYPFLCLLDEREVVRMLLQVLQALPAQGESFTTLARELSARTFSRHVVQRQRVSGQVQALQNHYRKYLCLLASDAEVPEPCLPRQYWEELGAPEALREQPWPLPVQMELGKLLAEMLVQATQMPCSLDKPHRSSRLVPVLYHVYSFRNVQQIGILKPHPAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHSGAFLLSPTKLMRTVEGATQHQELLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQLFQAKGCPQLGVPAPPSEAPQPPEAHLPHSAAPARKAELRRELAHCQKVAREMHSLRAEALYRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHLGSDVARALLEFAQGRPLGPHGLDWLKIHLVNLTGLKKREPLRKRLAFAEEVMDDILDSADQPLTGRKWWMGAEEPWQTLACCMEVANAVRASDPAAYVSHLPVHQDGSCNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVAAQVEVFRRQDAQRGMRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRELSDFPQEFVWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGSVVEWVTPLGVPVIQPYRLDSKVKQIGGGIQSITYTHNGDISRKPNTRKQKNGFPPNFIHSLDSSHMMLTALHCYRKGLTFVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVKRFCSEPQKILEASQLKETLQAVPKPGAFDLEQVKRSTYFFS
The following text describes a protein:
Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
ETIEDTYSRKTPLEHILLRPSMYIGPTEHADPKSCSSTNSPWTMQRQELSYVPALLKIFDEILVNASDNRLRHPGSCNHFPSSSDPYISITNNGKSIPIQIHRKENMYIPELLFGHLLTGSNFNDDQKRLTGGRHGYGAKLTNVFSKQFVVEIGDGHSSKGKIKTYKQVWEDNMSVCHEAEVVSRDKKDADGKGNLDYTRISFIPDLARLTGDRKTEMLPEEEYQLMKRRVVDIAGCSGGKLTVTLNGEEISVSGFEDYANLYRQPESSATPLPPMVYHKLNSRWEVAVGLSETKSLESISFVNGMNTSRGGTHVDALARQISQYIADHINNKMARQLDNLQSGQPISVSVRMVRRHLFLCVNCLIENPSFDSQMKECLTSNPDNFGSHFELSNSFLRKLVGPGIVEEVLRMAMGAQQVNMARLLKEQTKRQVLSIPKLEDANLAGSTDIGTENPCTLILTEGDSAKALAVAGLEVVGRDHYGVFPLRGKFMNVRNVTVKQLATNAELKAMCAILGLQFEKSYDTAKERQELRYGHVMLMTDQDADGSHIKGLIMNMFRFFWPALLKPPSRPFMSMFITPLLKATKKGKKKDSISFFSVAEYNSWRESLEDEDEISKWTVKYYKGLGTSTPTEAKDYFLSFVRHYRPFKWQSEKNDGERIDMAFEKDRANDRKDWILTEYDEKSAVTVDERDGNSITYGDFVDNELIHFSNANNIRSLPNVVDGLKPSQRKVLYACFKRNLKDEIKVAQLAGYCAEHTAYHHGEASLHSTIIGMAQDFCGSNNINLLTPSGQFGTRLMGGNDAASPRYIFTHLSPLSRLLFPVDDDMLLNYKEEDGQMIEPEYFCPIIPLLLVNGCQGIGTGWSTFIPQHNPLDVLNYIRAKLDETKKPAIRPWVKGFEGGITVDSKRGDYVTEGIITPQKNSSVVISELPVGVWTNDYKATLVAMLKKAEIKSFSQNHTTTTVSFNVKVNAAKLNRLLKGDMLKTFKLRKALSTRNMHAFTTDMKIARYNSPEEIADAFFPVRLDLYADRKSVLESNMEYSASLMRNKARFIEAVSANKIDLLHGRKSKEATTALLEEMEFSKQSELDAIKSNNNIAQRRESSNVVMDEFMSDEESAKGAAKEYDYLLNLPLSSLTLEKIDALNDDAAKTDTKLEQIKNTTPADLWREDLNRLEPHLQ
The following text describes a protein:
Function:
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity); Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus matrix. Cell membrane.
Domain:
The central alpha-helical coiled-coil IF rod domain mediates elementary homodimerization.
Sequence:
MSTRSVSSSSYRRMFGGPGTASRPSSTRSYVTTSTRTYSLGSALRPTTSRTLYTSSPGGVYATRSSAVRLRSGVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGHLYEEEM
The following text describes a protein:
Function:
Acts as an inhibitor of dendrite extension and branching.
Subcellular Localization:
Secreted.
Sequence:
MGRRMRGAAATAGLWLLALGSLLALWGGLLPPRTELPASRPPEDRLPRRPARSGGPAPAPRFPLPPPLAWDARGGSLKTFRALLTLAAGADGPPRQSRSEPRWHVSARQPRPEESAAVHGGVFWSRGLEEQVPPGFSEAQAAAWLEAARGARMVALERGGCGRSSNRLARFADGTRACVRYGINPEQIQGEALSYYLARLLGLQRHVPPLALARVEARGAQWAQVQEELRAAHWTEGSVVSLTRWLPNLTDVVVPAPWRSEDGRLRPLRDAGGELANLSQAELVDLVQWTDLILFDYLTANFDRLVSNLFSLQWDPRVMQRATSNLHRGPGGALVFLDNEAGLVHGYRVAGMWDKYNEPLLQSVCVFRERTARRVLELHRGQDAAARLLRLYRRHEPRFPELAALADPHAQLLQRRLDFLAKHILHCKAKYGRRSGT
The following text describes a protein:
Function:
Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.
Subcellular Localization:
Cell membrane. Synapse.
Sequence:
MGWKLSLFHNRMFMLDWYHVTPMLSSLVSHAKIRLGSEPLSQASGSTLAPVQQLKSVSFSAIGRHVPIAHVTFDLRNPGAFIATNQFIGFNKPASLYILIFLTILIMKEEPKEVSSNRKDTVNTEKRNDHDLTLQESLQTDTKVEKSNSTREKEKKRPQKPESSKVGERASKLQGQRAPTKNTEKANAPVSTKTKQKKTSSASSAKRPSTKQTMRSVIGGPGHPPCPSKDSEREVEIRLLQVECDELRNRLGCLKEGLMGQKPSDVEQLLRQSQKELLWLQRQLSFISNGGPACILSPNKFRNDLQCLPPSVQHRSYSHIQFLEEKSRPFKSDVTSVSPEKLHWNFLEDELKDVVQDKSRLSLQYASLSHRALLYDQVKSDYEQLRETLVIVTRERDLAVKEKYQLQAKLENLEQVLKHMREAAERRQQLELEHEQALAVLNAKQQEIDLLQKAQVEAKIEHEGAVQLLENTLDSMQAKVRELEEKCRTQSEQFNLLSRELEKFRQQAGKIDLLSGNAGGVLDFPGSPNKTLTQFINGIATSISKGNESPTGSRSVISEYIRPLQITGDKPEQLCVKPTFLSRSRSGSPRRGFECNMDKEQNTNTSKQRYSGKVHLCIARYSYNPFDGPNENPEAELPLVAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQNDEFHMSSTLASEQEENILNHSAPLLQSELKLEITPSIHMESSVLNNGTGTTMDVNIDEIGEDIVPYPRKITLIKQLAKSVIVGWEPPLVPPGWGTIHSYNVLIGKEIRATLNFGSRTKLLLEKLDLATVTYRLSIQTVTDRGNSDELQCSLLVGKDVIVAPTHLKVDNITPMSAELIWLPSNSNYSHVIFLNDEEYDIVKAASYRYHFFNLKPNMTYKVKLLAKPHQMPWQLPLEQRERKEAYTEFTTLPSGPPIPPDNVIVHQGPTPVTLLVTWKPPVLSPTGTSNGAHVTGFSVYARGQKVAEVVFPAAENIVVDLLKLLNLDAKEVTVRTLSAQGESEDSISALIPPDLMVPPIQHPRTMPKCKPLATAGVPDTKDDHVCPHRKVDESWEHTRTASPVHGHTLEPPTSNFHSPVHGRRSPSPQRILPQPQGAPVSNTMAKAMAREAAQRVAESTRNEKRSLFSERSNSVHYANSDEEEDGYDSPHIKRKGASVDEFLKGSELGKQSHYCPGEDYHTESSRGSDLSDILEEDEEELYSEMQLEDGGRRRVSITSHNTLKCSKTSTTDPALKEQLDYSPQHHHSKKLFSIPEVAEEEGGEHSELLHRGCSIGITYKTRGALASVNRIPRAGSREGRHQSPWHLSKARFNGTPTYSEDFTTEGSKLGSLSRSPDSGLDCGSEEEEARCNYRKATVARNAAQENPQNPPCPRDLKQMLTRRKTLTRQSSVEEDFGDMSAGFVDNKSNIKHQPEMHEQQPCIRDLNNISARKTDFYQKDHRDAVLRPPHRDTENSLLLGNHPTLSRTDHQTRRFSHGSAAPQRPRPMMVPSIEITMDSNSEGGRSRSGSEGNISPVKEEAYYRSLGGHRKWSLQPTRVSDDRYDSYGSREQLSMYEESETDGGMEDFPARIFVALFDYDPRTMSPNPDAAEEELPFKEGQVIKVYGDKDSDGFYRGETCERAGFIPCNMVSEIQVDDEEMMEQLFKQGFLPLNTPVEKIVNCERFKESSRSVHRRSRKSKRERNRRSGRQHSVTTRRMVALYDYDPRESSPNVDVEAELTFCTGDILNVFGEIDEDGFYYGELNGHKGLVPSNFLEEVPDDVEVYLSDTPSRYPQDTPMRTKVKRVPSENTGTPRRAPSPTVHLHSMSPPSSMGSGSPMRGRDRSSKKKKGLLSKGRKFLKKLGAVK
The following text describes a protein:
Function:
Transfers N-acetylgalactosamine onto carbohydrate substrates. Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-3, bre-4, and bre-5. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRQNRRASMIVNRILITLIVLVSLSFLFLRAGPKFSEADRACIQDEWQENKSLNVSSEINNETYQIVFADVQKEFKWIFLPKEISGNPDILMIVSSNRDNFARRNVIRKSWMNSDKNKIVAEKRMKILFLVGVNSENEKENTVVLKEAEVFGDIIVVDLEDNYQNLPYKSLTILLYGQSKTAESVKLIGKIDEDVIFYPDQLTPLINDGTINMSISAIYGEKWNAGVEVSNKDETNKWFIPKYSFKCQLLPSYLSGPFYLTTRKAAERILKSTKHRKFISVEDVFITGLLAGDVGVEKKQLPSMYMYDETTTDTAKAEILAWHNFKNNAEFLESWENLRLSRCKACRKSRNFRGSRSQLDEERNQ
The following text describes a protein:
Function:
Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein.
Sequence:
MAKETRGKANLRKHSASHWRMQNIAQESVDSSDDEFFDAREVLEGKTAMLLGMSQWNSNDLVEQIETMGHIDQTQESLYRVRRTKCIPQTSIDGLEEAEKCQTHVLVLVVHGGNILDPAGGEPGAKTTDVNTLSSVLEKVSQAHFQAAAQHVVIKLVPCPAVCAEAFCLVSNLNPYSYDESCVSSSVDHLPLAALPLLAIAAPHYQDAVATVIARANQVYHRFLQSPEGQGFTGQVCLLGDCVGGVLCFDALCFSNSPRHSSPIHSSRHNSTESLKDNPDVSPSLSSSKRLSRSNIDLSAPSETRNRKTPLSRKQSDSYDGDSGGQHHPFLSSLIQDGADLRPNSSTSLVLNPGRFDFEVSDCFLLGCPLGLVLAMRRTVLPAVQVSQLRPACSQIFNLFYPSDPSASRLEPLLHSQFHKLPPFPVPRYQRYPLGDGRSNLIADEIPSYPDAFLPGSVVPVGVLQPSSPQTERTAGVRVGGEVRRSSLTSMDSQSSGCLESRLSSTIANISSSWWGSKRLDYALYCPDVLTSFPTVALPHLFHASYWESTDVVAFLLRQVMHCDYVKAQEMDNCDSAPFSPSSPREKWLRRRTHVKLRNVTANHRVNDVIATEDGHQTLVGRFMYGPLDMVTLTGEKVDVYVMTQPQSSRWVHLDTEVTNSSGRVTYTIPKSKKLAVGVYPIKMVVKGDQTSGEAFLTVLPRGMECVVFSIDGSFAASVSIMGSDPKVRPGAVDVVRHWQDLGYLIIYITGRPDMQKQRVVSWLSQHNFPQGMIFFSEGLVHDPLRQKTIFLRNLMQECHIKINCAYGSMKDISVYSILGLSPNQIYIVGRPSKKYQNQCQFLSEGYAVHLSSLQFSHRARPKKSSSVRMVLRKGSFGLSAKPDFLCKRTHLRRTMSVQQPDPPMTPNPKPERAQSQPETDKDHGGGGGPSHALWARGSMHRGDTTP
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MASGVEVLRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLLLSCYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEPKIGLKEDGVSEASLVSSISATKSLLPPARTPKPAPKPPPPPPLPPPLLRPVKLEFPLDEDLELKAEEEDEDEDEDVSDICIVKVESALEVAHRLKPPGGLGGGLGIGGSVGGHLGELAQSSVPPSTVAPPQGVVKACYSLSEDAEGEGLLLIPGGRASVGATSGLVEAAAVAMAARGAGGSLGAGGSRGPLPGGFSGGNPLKNIKCTKCPEVFQGVEKLVFHMRAQHFIFMCPRCGKQFNHSSNLNRHMNVHRGVKSHSCGICGKCFTQKSTLHDHLNLHSGARPYRCSYCDVRFAHKPAIRRHLKEQHGKTTAENVLEASVAEINVLIR
The following text describes a protein:
Function:
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MAAAGPSVFLLMVNGQVESAQFPEYDDLYCKYCFVYGQDWAPTAGLEEGISQITSKSQDVRRALVWNFPIDVTFKSTNPYGWPQIVLSVYGPDVFGNDVVRGYGAVHVPFSPGRHKRTIPMFVPESTSKLQKFTSWFMGRRPEYTDPKVVAQGEGREGKAWSPHHHPPQPPSLPWEGQDASQGTARHLGGLWEQPQASRWNSTHPPTPHTPSPHCLSRCGPCTSWWGVWARQERPWRLSHPHSNLADGWRPLPSDPRPLPGLCHSPLQRGDQGHEEAGLRHWASRHAGHPRAQPTTGPPPVKAHTGHGHHHHHCIRPRGSQVTQGCPSGEPATDPCA
The following text describes a protein:
Function:
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
Sequence:
MASSLLTRQLALSLQQNLRLAAPGSRYVSKTATKTVSEFEYDAPSMKTTVPGPKSKELLRQLGEIQNTGAIHFFCNYEESRGNYLVDVDGNRMLDVYTQISSIPIGYNHPALMKVMTNPNNVSAFVNRPALGILPPENFPEKLAESLLSIAPSGMTKVQTMACGSCSNENAFKSMFIWYRNKERGYATPSEEEVGTCMVNQSPGCPDLSILSFMGAFHGRTLGCLATTHSKAIHKLDIPSFDWPIAPFPKLRYPLEEFERENAQEEARCLEEVEDLIVKWRQKGKPVAGIVIEPIQAEGGDNHASPDFFIKLRNIARKHGCGFHVDEVQTGGGATGKFWAHEHWGLDDPADLVSFSKKMLTGGYFHRDELQPDKPYRIFNTWMGDPSKNLFLSEVLNVIRRENLLEQVTRSGKALLQGLYALQSQYPHLLSGARGQGTFCAINASSDATRDSIMLKARNKGVFLGSCGEKSIRFRPALVFKEYHVHQLLNILNDVLAEHK
The following text describes a protein:
Function:
Provides the (R)-glutamate required for cell wall biosynthesis.
Sequence:
MSKIGILDSGVGGLSVLKEVYLNNLADEVYFLGDTKYFPYGIKPVEFIQERVFEIVSFFKSLGVEEVIIACNTASSVAYDFLKDRFRDLKIHSIVLGAIEGAKNYKAKKIGVLATRRTMESNIYPRLIHEKISDKIEVYVQSCSEGPLLETIEKGIVEGELIEKEIMRCIDPLVEKNIEGLILGCTHLPFVKKVIKDLYPNLFVVDPSLEVINFLRSDSNFNTKVEIFVTGEAEEFQGILNKLLGMDWIVKKVTLDRSDVSVIKG
The following text describes a protein:
Function:
Acts as an inhibitor of cathepsin B (CTSB) activity. Plays a role as a negative regulator of tumor vascular development, cell invasion and metastasis.
Subcellular Localization:
Secreted. Cytoplasmic granule. Note=Localizes in cytoplasmic granules of neutrophilic precursors.
Sequence:
MAGLWKTFVLVVALAVVSCEALRQLRYEEIVDRAIEAYNQGRQGRPLFRLLSATPPSSQNPATNIPLQFRIKETECTSTQERQPKDCDFLEDGEERNCTGKFFRRRQSTSLTLTCDRDCSREDTQETSFNDKQDVSEKEKFEDVPPHIRNIYEDAKYDIIGNILKNF
The following text describes a protein:
Function:
Probable cyclin-dependent protein kinase (CDK) inhibitor that functions as a repressor of mitosis in the endoreduplication cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MAEICCVKEIQEEDVEKIRLPTRPELDIPDSDHEDPTVNEEEGCKTPTSSDHKIPEVKYTLCPPAPRKPKPNRSSGTKRKLTPVNVVNRIPIDLSREIEMFFEDLDRRIKKSRKQ