lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MSTPSNNEERMRLQLSSVPETSSSPMVFPSSSAGHPTSDAAPHSASRVQGIRRTAQSHINSSSPLRFPSSSNSTITGRRSGRANPNPSSEPLFFPPSSGEGTPRASRPSNRRGDIHSTVPSLSSPSAHPRLHAQVPSSSAGLGQTPNVPGSDLPSQHDTSSQAVPAEPETQTVIWGTLVSLQDSMQTFRQFLQGFKRKYRLAFDLKLSLDDASMLSNGDQLVYVDYMRKMRLTSQTNLNLDLINLLAFPPTKNLYNQILNYPQELIPICDQVLKDCVIELAEEDRERGDLESEAVPGDEEIAEMEGRIYKIRPFGYAGQSPESTVTTAAGQPVHRGVNMRLLNPGDIDKIVAIKGLVIRATPVIPDMKLAFFRCLSCGHVTTVEIDRGKIAEPQRCPREVCNQPGGMSLIHNRCEFADRQVIRLQETPDEVPDGQTPHSVSLCVYDELVDSAKPGDRVEITGIFRSVAVRVNPKQRVIKSLFKTYLDVLHIKRSDSRRLGVDLSTRSTDGRTNEGVVGVGGDDEEEQTSGGGVSSSEDNLFRTGADNPSNRAELEEKLLELSRRPEIYEILSRSLAPSVWEMDDVKKGILLQLFGGTNKTIGGSAASRNGSGGPRYRGDINVLLVGDPGVSKSQILQYVHKIAPRGVYTSGKGSSAVGLTAYVTRDPDSRQLVLESGALVLSDGGVCCIDEFDKMSDATRSVLHEVMEQQTVSIAKAGIITTLNARTSVLAAANPVGSKYNLAWPITKNIDLPPTLISRFDLLYLVLDKVDEASDRKLAKHLVALYLEDRPETGGLDILPVQTLTAYISFARNHIHPVLTEDACDALVRAYVTMRKAGEDSRTSERRITATTRQLESMVRLSEAHARMRFSETVDVADVEEANRLIREALKESATDPITGLIDLDLLQTGQGLHQRKLQEDLKREILKLLDSAQTQSTGGVRWPILFELLANQSSLPIDPSEFADVLKALADEGLVSISGERDKRLIFRTSSLNPS
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MKLPLLLALTALLAGAATGQTQSPSVDDEGSSGDINDDGDDLYSGSGSGYFEITVRPTSVGVSFTTEEPFLFSTTQATSPAPSASPAAEPSPSPEDVTITPLPTEVDGESGAFWDKEKEREMAERERERQMEKERQRQMQREREREQLREMERQRERELEREKERERIRAAAQTTVAPRYPGVLPVVTSNPTAGPGESTVPSAGSDDLTSFTNEEEDFSLPTESTSTSYDPGFDMESTTDEDTRTTTEATPEPTTAAPTISASVPFRPRVPITTATKAAPTERTTRPQQPTTTQEGTNEVGAVGPSGDFEIREDNRNNVGRELPGDPDLIGNTVDGSSSAAQLPQKNILERKEVLIAVIVGGVVGALFAAFLVMLLVYRMKKKDEGSYTLEEPKQATVTYQKPDKQEEFYA
The following text describes a protein:
Function:
Has a role in substrate recognition in the Skp1-Cullin-1/Cdc53-F-box (SCF) ubiquitin ligase complex. Required for the maintenance of telomere length and transcriptional silencing at the telomere. Also required for chromosome segregation.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MNNYQVKAIKEKTQQYLSKRKFEDALTFITKTIEQEPNPTIDLFELRAQVYEKSGQYSQAELDAKRMIHLNARNARGYLRLGKLLQLDGFDKKADQLYTQGLRMVHKMDPLRPVLKKVSQRLNERILRTRPVLDLFRILPREVLLCILQQLNFKSIVQCMQVCKHWRDCIKKEPSLFCCLDFSCASPRSVNSRDRNVMAVARYSVYSKDNIQEVIGLEKLGILTPTKALLRSVKSLKVYKTISPLHTQSTDKLYTIWTPFSELHYFYCATPITFSIASKILSCCKKLKQVELVDLIPDLIFDSMDWDKLFNAESVPLALKSLTFIRNQKFPFHHKEQQFLKDLLSASPYLEYLEASYQSDLVAAIKKYKINLRSLIIIDEGVSNTVKDLAFLPQSLTTLIVKPCNPASTILCPYLFPTNVRMESLINLELFLYLRLSQNDIDNVVKFLTSCYKLKKLVLHDSLALAPHFFEIFASLPELEHLEIPDNVALQNKHAIHITDCCPNLKYVNFSNSISLDGSGFIAVLRGLKELKRIDIINCDSVSRDAIDWARSKGMQVTVASSLPNSQPLGTKKIRLI
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
LDFHNTQTAFQDKSLTDLLLAYAVYKACMFSPLVKHADSVYKLSRRFLGPRITDGVVRATFFRHFCGGENNNDLLETTTSLKNSGIGAIMDYAAEADVVKKPDVVSEVKAKSSARVYDYISEAQCDRNVQHFLDCIESVHQVTPGGIAAIKITALGLPDLIERMAVAITRTQWLFSLIDSDNSGTLSADEFEKAVATFFPDIDAKEVFHAIDTDSDSEVDYIEWTHSLRMEDVWNLIRSAGPNTPLGELQEAMLDETELELMRNMMRRLHTLVDYAAERKVRLMVDAEQTYFQPAIHNLALGLQRKYNKELPLVYNTYQCYLKDTLSTLEHDLQRARRENWWFACKLVRGAYMEMERQLASDKGYPSPICDTQDDTHRTYNTSINMILNQDRANLLVASHNQASIEYTISEMQKRGIDKQTGGVCFAQLLGMCDHLTYTLGINGYKAFKYVPYGPVNEVIPYLVRRAHENRCVCASFCLGTGQPHQQLLTLLLVLTLSVMSPLQLNAGWSAA
The following text describes a protein:
Function:
Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
Subcellular Localization:
Nucleus. Cytoplasm. Mitochondrion.
Sequence:
MKIVSWNINGIRTFKAGIKKSLDALDADIICLQETKVTRELLDERTAIVEGYNSYFSFSKGRSGYSEGVATFCKDNATPFAAEEGLTGLLTNHSGAVGCYGDQAEFSDEELQTLDSEGRAIITQHRIVCGEREETLTVLNVYCPRADPEKPERRLFKLRFYQLLQIRAEAILGAGGHVIVLGDVNTSHRPIDHCDPDDVDDFDENPGRKWLDHFLAGRNPEEGKAGEEGEGAGTDSRDAAGGTRGGRFVDTFRHFHPARSHAFTCWSTVTGARRTNYGTRIDYILASRGLAEAEFLDSDILPEVEGSDHCPVRGLLRCALLASPRCPPLCTRHMPEFMGRQQKLSRFLVKVGQAAAATAADSQLPGSQESGEVRENLPPAAETGRGSGTKRRPLAEPSASRNKKARTATSGPRQQGNLLAFFRPRPTGAGRGATAAGDGDPLGGRQDSPARVGGTPEENELSLPGSAQPDGPVPEVEEEEEEEEEEGGRASQKPQHRDGEEPQRFWKSVLRGPPTPPSCKAHGEPCVLRTVKKPGPNLGRQFFVCNRPQGHASNPDARCNFFTWVAKGR
The following text describes a protein:
Function:
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPPKKKNKPQRNGFWVYMQEMIPEYKRQGYQMPNGMADVVKLAHPSWKAMPEMEKQEYERQAKELKKSASATAGRLDCKGRPLADRVDTKAILEKRRLEERRRVVAAWPPGRGVVHEKFLLLSIQSLCELPDDMGYMPCEIGVVEYSLQEGITREFHRFIQPGKPPLGYRYLCQSTSDNTHQIPIEGFELAEGDYHRLWTDLCKFTSPNGRDFPPLYVQVTHTSMCEWCLDWLSEMAGEYNRFHVYELDSLVKDLYEHGEGHAPSLSMIASILNTSVFDYEDGSSCEYHASKEVKYCALGAVKRFCFSISDSMAQVYDLQLTARHLPERPENQGHYTILPSDAFALDRRPMWDPPSRQRTTSQPRGAAYNPPPSYSRDQRNGIAAASPSEGNFPARDIRVLTQATHSASSSNVPETQALRKPTTPGEYLYLLQLFFHRTYCLQFVSTPTKTTGNVKGWCELSKGGCLTVKATYF
The following text describes a protein:
Function:
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
Sequence:
MLYRLVSHIPHILFKPVYDAYESYLLEKVKSGNIPKHVAIIMDGNRRWARKLEKPPWYGHLFGSKKLEEILEWCRELNIRTLTVYAFSTENFKRSKEEVEALMNLFEEKFKELVQDERVHRYGIRVNVLGRKDMLPENVRKAAEEAERATRKYSNYNLNIALAYGGRSEIADAVREIVRDVLEGKIKPEDIDEEAIKRYLYYPNMPDPDIVIRTGGEVRISNFLLYQIAYSELFFVDVYFPEFRKIDFLRIIREFQKRQRRFGR
The following text describes a protein:
Function:
May perform the conjugation of reduced glutathione to electrophiles.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPFDTKSIFPDFIVFPSAISTIAIGLWSVQAYKLGEARKRYNVKAPHVQGDPEFERIAHEYQNTSEALGAIIPATFMFSYYISPKCSLLLGGTWLVSKMLNCCSYCCKKEKENDCAKNVHTCLSHISFFALLGGSAFGIGSSLYNRYKL
The following text describes a protein:
Function:
Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner (By similarity). In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins (By similarity). In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (By similarity); [Processed fractalkine]: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils; [Fractalkine]: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein; [Processed fractalkine]: Secreted.
Sequence:
MAPSPLAWLLRLAAFFHLCTLLPGQHLGMTKCEIMCDKMTSRIPVALLIRYQLNQESCGKRAIVLETTQHRRFCADPKEKWVQDAMKHLDHQAAALTKNGGKFEKRVDNVTPGITLATRGLSPSALTKPESATLEDLALELTTISQEARGTMGTSQEPPAAVTGSSLSTSEAQDAGLTAKPQSIGSFEAADISTTVWPSPAVYQSGSSSWAEEKATESPSTTAPSPQVSTTSPSTPEENVGSEGQPPWVQGQDLSPEKSLGSEEINPVHTDNFQERGPGNTVHPSVAPISSEETPSPELVASGSQAPKIEEPIHATADPQKLSVLITPVPDTQAATRRQAVGLLAFLGLLFCLGVAMFAYQSLQGCPRKMAGEMVEGLRYVPRSCGSNSYVLVPV
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSDLRRVESLNADTFRRLNATSVVKSFWHTQLRAATAASRGAKDDSLATANEETPVATRKLRSAASSAEKSAGGLTDSTVYSSSSSSSNSRLSVSATLPGFPSPTETRRRLRAAALSAERHRAEESDEEKPDPVARTLFQNFLLQEYDALDSRPVLTVVLDLDETLVSNRDSGATGAILRPYCLHMLNALRHMQGLEVVLWTASTKETAAPVIRQLSQSGPVFDDVICRNSSWFTEPLHTKDLRLLGRDMSRVIIFDNSTACCKLNPRNAVIVDDFRGVRNTSDAALVNVYYIIERSFNGCCAGVSVLETLVKLAVEKQLCMPEVLHLPESWRHIPLREIAPLKVPPHGIFFRAHSTPLNDSIMQHWTV
The following text describes a protein:
Function:
Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Subcellular Localization:
Cell junction, tight junction. Endomembrane system.
Sequence:
MTVPINVEVKIGCVFQDAPYLTSLPEQVTSPLEEAVLQVNFPHSLAEAILGLIAVFDEQEPLQKIESPSGNPVDRQSPDAFDTEVAAQLAAFKPIGGEIVVTPSALKLGTPLLVRRSSDPAPGPHADAQPSTASPSGQSLKPVVLDSAQNLENRDVMNGEQTGLLMLHKTKNELSDMTRAVEISGEGDPLGIHVVPFFSSLSGRILGLFIRGIEENSRCKQEGLFQENECIVKINNVELLDKTFAQAQDVFRQAMKSPSVVLHVLLPQNREQYEKSVIGQLNIFGNNDSASRTKAPPPTRGKAGLKAVNPTRANSPEGEESPSPQQSKSPRVPRLGRKPSSPSLSPLMGFGSKKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAVKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETVSLVIARQEGSFLPRELKGEPDCYALSLESSEQLTLEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGETLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRLERPLEEISECGALSRPCFENCQEALSASRRNDSSLLYPCGTYSPQDKRKDLLLPSDGWAENEVPPSPPPHPSLEWGLEDFSHSSRVDSTGYFPDQHVNFRIVTPVGQPESINLKASKSMDLVPDESKVQSLADRRSDSPGKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRAAIDKSYDGPEEAEADGLSDKSSHSGHTALNCESAPQGNPELDDVENKAKNVKKTKEKEKKKGKGKMKVKEKKQKEEHEDTERKMKRKGFGAMLRFGKKKDDKVGKTEQKGTQKSGHPGEEELERMKEERERIGAKHQELREKQARGLVDYATVATGPVHDIDDDEMDPNYARVNHFREPCTSANVFRSPSPPRAGTLGYPRDGRPLSPDHLEGLYAKVNKPYHPPALADSGRPMAGTTDRIQKLRKEYYQARREGFLLYEDEEGVTRPSDYDLHWVSGKGPDGSAHNLRFEGMERQYASLPRRTSPQGDLAWLPVPPAHGPLALALRQQMIAADSSRSIGDKPVCMQRGGQQM
The following text describes a protein:
Function:
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
Subcellular Localization:
Cytoplasm.
Sequence:
MIKELEDIFKEAEKDMKKAVEYYKNEIAGLRTSRASTALVEEIKVEYYGSKVPIKQLGTISVPEHNQIVIQVWDQNAVPAIEKAIREELNLNPTVQGNVIRVTLPPLTEERRRELVRLLHKITEEARVRVRNVRREAKEMIEELEGISEDEKKRALERLQKLTDKYIDEINKLMEAKEKEIMSV
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MARNSEKAQSMLFRFREAQAADLGIIDAGRTRRPRSITEQDSIPACEKWRGQVLKEISRKVSRIQDPALSDYQIRDLNDEINKLMREKHMWEVQIRNLGGPNYMRSGGKVYDEAGREIPGGGRGYKYFGRARELPGVKELFEAAARAKQDDEKPLETRDDLRKQVDAAYYGYAPDEEDEKLLAYEAARERQAFENLAKAAAGLEPPPGWEPLPEWELPTMDEVAQELIDRRRRRLLDQL
The following text describes a protein:
Function:
Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Nucleus and/or cytoplasm.
Sequence:
MADEPTESTTNLVATPDPAPTTQEPEPANEIPETSDSPQIANPLELPLPEKPPAEQNAPLFAPSPTASENNQGNDLPTLSPTIIENKQEADDPTPLSPTASENRQTSDPSSTASENKMNNDPSPATSENKQTNDPSPSTSENKQTNNDPSPTPTSENKQTNNDPSPPLTQPVLSRLASLRQRVEKDPMDGEAWIELIADAEKKGDLEKTREVYSSFLQHFPDAANQWIAYADLELGHGHFPEVEQIFSRCLRSSVSVELWAFYLNYIRRVNPVEGDKAAASRAIIISAYDFSLNHIGIDRESGQIWLDYINIVKAGEAAGTWQEQQKMDSLRKLYQRAVCIPLDNIEQIWKEYDGFEHQMSKMTAKKFLADKSAQYMTARGALKEMKSLTDPLLRPRVPAKPNWKRISDHKQLDQWKTYLAWEEKNPLEIADKNLLNTRIQYAYRQAIMHMRFYPEIWYLAASHLQKNDKAEEALAVLQAGLTANPTSIVLTYAIVEAHENLKNYPACYAAFNSLIEYYHSEIDEINKTIEKEIAHGIPIIESKTANPTTLPDGEADQELTEEEKQRAKEEEQLRTNITALYKPKIDEFREAAASVWITEMRFARRTEGIKPARAVFTRARKAPYITSHVFEASAMMEYHWNKEPAVATKVFDLGLKTFSEDVNYVLQYLHFLITLNDDSNARALFEKTVSKIPPESARPLWRRWAAYEFIYGDKAASEKLNSRVAEIFPDWGVVERLSDRHAYADLGDVLGRELGTAIEPIPLRNRSPSPAPGHQEGFGFKRGGAGGHEAGHHPGGIPSGPASYRNRQQQHHLRDRSFSPDFRPKRPRGQRSSLSPERRNGPASLPPSVIDGPSNPPSKRGRENYENNPKRNRFSSPPSRSRESPPPPNPYAWFPEGLRYFLGILPLATSFEGPRLDTNTVLQVLSEATIPVSPSAPKNNSGGTPHGPSNVSGWGPNRGGGNGTSGRGNHNATRRGRRK
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MHKTNNSASPNFKLINNKNNKSKLDTTTNNGNNVSMVKKDIKQQGNQYSQLQSARPRTQSTQKKESVSKDKQQPLKHLDPQKRLVTNPNSSAERVVNKQRTHSTSGRTSTLSPQSRVKPLATKNITQQQQQQLNNSNQQPTPRSVKKQMFISGNVKETKNNCNIISKMKPNFEKGKSLPFKKESPAIKLNKQDSNTISSQSIQTRSSKQSLSVHKSITVNRMDDLFQRSKTPLNKNLPNDPFYCIVNPQFKDAKYYQTSLIHYHYEQVRNKYSPFKIHFELQYNTNQLKEYFSDLFCEHFQQSFTCLQYCKRLTQTLKQNNKIQYLPPNENHTKTLVFDLDETLLHCNENVNDPTDHTIMVNMPNEGMVKTKINIRPFCQQMLKLLSNHFELILFTAAYQYYADKALELIDPERKLFQYRFYRESCLEIEEGLFIKDLRVIGNRQIENLLLIDNAPYSYCYQIDNGVPIIPFYDNKFDKELVFLTDYLLKLEKNKQWTYANKVHFRTYLYQQCLTADECLREMFKAYDTYTY
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MQAPPCCLSDEEELEKLQIKGLAALKAAVAELNGTPSKSTCNTNNGELKKDINKNNEHCENQKINQGFGSSEAMRVSRKQRPCYKQLQREIQRLAGEQEFPQTQSQHQGLSESYIQSQDPDAQVCVSKVMQLYKIDNNPKRKEFLDDLLNLLKKHGTPIKRTPIMANKVLDLHKLYELVAERGGLREVQKNKLWPEIAKILTLENSVRSPTSKLRMKYIKYLSLYEYENRSRRILETPHTIKEGGEGERWVPKQIPGARLFGKHFSPDTSSETERKKNDVSWSLSPILAHLHQPETDQAQMAAQGPSPLAGTAAASQSPNGQKRGEKRFTEAIVEKDKRKKLMNMATELTECKCTRHIDGILDIESTDNFLIALECKGITYKGLLYRQ
The following text describes a protein:
Function:
Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (By similarity). Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVLLKEYRVILPVSVEEYQVGQLYSVAEASKNETGGGEGVEVLVNEPYEKDGEKGQYTHKIYHLQSKVPTFVRMLAPEGALNIHEKAWNAYPYCRTVITNEYMKEDFLIKIETWHKPDLGTLENVHKLEPEAWKHVEVIYIDIADRSQVLSKDYKAEEDPAKYKSIKTGRGPLGPNWKQELVNQKDCPYMCAYKLVTVKFKWWGLQNKVENFIHKQERRLFTNFHRQLFCWLDKWVDLTMDDIRRMEDETKRQLDEMRQKDPVKGMTADD
The following text describes a protein:
Function:
May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity). Involved in abscisic acid (ABA)-mediated signaling pathways leading to the production of hydrogen peroxide H(2)O(2) and the subsequent [Ca(2+)] cytoplasmic oscillations-dependent regulation of stomatal closure. Required for [CO(2)] modulation of the cytosolic Ca(2+) transient rate and for high CO(2)-induced stomatal closing. Essential for both cold and ABA induction of XERO2. May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton. Cell membrane.
Sequence:
MGKKGSGGWFSTVKKKVFKSSPKDSKRENNIGSNNADIWQQQHDTQEVVSFEHFPAESSPEISHDVESTASTPATNVGDRKHAMAVAIATAAAAEAAVAAAQAAAKVVRLAGYNRQTEEDSAAVLIQSHYRGYLARRALRALKGLVRLQALVRGNHVRKQAQMTMKCMQALVRVQGRVRARRLQVAHDRFKKQFEEEEKRSGMEKPNKGFANLKTEREKPKKLHEVNRTSLYQTQGKEKERSEGMMKRERALAYAYTYQRQMQHTNSEEGIGLSSNGPDRNQWAWNWLDHWMSSQPYTGRQTGPGPGPGQYNPPPYPPFPTAAATTTSDDVSEKTVEMDVTTPTSLKGNIIGLIDREYIDLGSYRQGHKQRKSPTHIPSYMAPTASAKAKVRDQGPTVKLQGTSFMPYWNSSTKNGSVNGSGCDSSSSGGAITTGYPGPRSPNPKSDIRRKPVSPSQSPTGFGKRGWRHDH
The following text describes a protein:
Function:
Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4-amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP).
Sequence:
MKFCDRLLETVQPVWEMSHNHPFVVGMGDGTLEKDKFQYYIIQDYLYLLDYAKLYAIGVVKATNPQVMGKFAEQIDGILNGEMTIHKQYAKRLGISIEEIESAKPSAKNLAYTNYMMSVSQNGTLAELIAALLPCMWSYWEIGKRLNDIPGARDHEFFGEWIQGYSSEEYGNLCIWLIDLLNEMAVGKSEKELERLEEIFLYSSRFEYLFWDMSYRKEMWGFEEQEHTTVS
The following text describes a protein:
Function:
Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. Controls the resistance of E.coli to dyes; required for expression of the alkaline phosphatase and sex factor F genes; it may also be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expression of genes of aerobic function. Activates the transcription of the plfB operon by binding to its promoter.
Subcellular Localization:
Cytoplasm.
Sequence:
MQTPHILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSEYDINLVIMDINLPGKNGLLLARELREQANVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGTVSEERRSVESYKFNGWELDINSRSLIGPDGEQYKLPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLED
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
SLICGETVDMEEIHHYYPIKSLFTLSPASLHIKGLLFCLFVPAVLPQHYASEEDLCNQQCNLRMEQGEPKPCQIREEHGEPKPPQIKEEHEEQEPSQIKEDLQEPDTQQIKGELQEPEPLQIKEEQVEQQLPQIKDGLFKGNQHEESTTTTDQDTDPQNRDQKKSFSYLSHLKTHMRTHTGERPFSCKVCKKDFRYLSHLKRHMRIHTREKPFSCEECDKCFIQIYDLKTHMRTHTGEAPFSCKECDKVHMRIHTGEKPFSCGECGKRCSNLSDLKTHMRTHTGEKPFSCKECDKSFSCASNLTTHMRTHTGEKPFSCKECKKYFNQTSSLKTHMRIHKIGKPLSCKKCDKSFSCVSSLKTHIRTHTGDKPFSCKECEKSFRFLSHLKRHMRTHRREKSAVPPVVCVYIYASQGKNKIRNSCVYFVCSFCTRRNSFFC
The following text describes a protein:
Function:
Performs an essential role in the oxidative function of the citric acid cycle.
Subcellular Localization:
Mitochondrion.
Sequence:
MAATGGRRGVRAMGEMLLRSQQRRTVTYMPRPGDGRPRAVTLLPGDGIGPLVTGVAVQVMKAMHAPVYFEEYEVSGKMDKVPNEVMDSIRRNKVCLKGGLATPVGGGVSSLNVQLRKELDLFASLVHCFNLPGLKTRHDNVNIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRKTVTAVHKANIMKLADGLFLESCREVAKKYPAIKYNEVIVDNCCMQLVSKPQQFDVMVTPNLYGTLVANTAAGIAGGTGVMPGGNVGAEHAIFEQGASAGNVGNERLVAGRSANPTALLLSSAMMLRHLQFPSFADRLEQAVMSVIAEGTFRTRDLGGTSSTQDVVDAVISKLN
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of sterigmatocystin (ST), a polyketide-derived furanocoumarin which is part of the most toxic and carcinogenic compounds among the known mycotoxins. The first step in the biosynthesis of sterigmatocystin is the production of hexanoate by the fatty acid synthase (FAS) units stcJ and stcK. The polyketide backbone is assembled by the non-reducing polyketide synthase stcA by condensation of the starter hexanoyl-CoA and 7 malonyl-CoA extender units followed by cyclization and release of norsolorinic acid (By similarity). Norsolorinic acid is the first stable intermediate in the biosynthesis of sterigmatocystin and is converted into averantin (AVN) by the ketoreductase stcE which reduces the hexanoate ketone to an alcohol (Probable). Averantin is then oxidized into 5'-hydroxyaverantin (HAVN) by the cytochrome P450 monooxygenase stcF. 5'-hydroxyaverantin is further converted to 5'-oxyaverantin (OAVN) by the 5'-hydroxyaverantin dehydrogenase stcG. The next step is the conversion of OAVN into averufin (AVF) which is catalyzed by a yet to be identified enzyme. The cytochrome P450 monooxygenase stcB and the flavin-binding monooxygenase stcW are both required for the conversion of averufin to 1-hydroxyversicolorone. The esterase stcI probably catalyzes the formation of versiconal hemiacetal acetate from 1-hydroxyversicolorone. The oxydoreductase stcN then probably catalyzes the biosynthetic step from versiconal to versicolorin B (VERB). The next step is performed by the versicolorin B desaturase stcL to produce versicolorin A (VERA). The ketoreductase stcU and the cytochrome P450 monooxygenase stcS are involved in the conversion of versicolorin A to demethylsterigmatocystin. The Baeyer-Villiger oxidas stcQ and the reductase stcR might be involved in the biosynthetic step from versicolorin A to demethylsterigmatocystin. The final step in the biosynthesis of sterigmatocystin is the methylation of demethylsterigmatocystin catalyzed by the methyltransferase stcP.
Sequence:
MILPLILVLYLLSTAAYRLWLHPLRNYPGPCWWAVWRVPYLKGTIRGTIVRDIQRLHNQYGPVVRIAPDELSYITPEAAKPIYTSSPEFPKDPMHLPPFHNGAPGILAADYAHHRRYRRLLASAFSEKGLRAQQGMIQSHIDRLMTRLQGNCSSGSLDMTVWFNWATFDIIGDLAFGEPFGCLERMETNPWIASIQGNVKSIPILNALRRYRLDRLIEFLAPPRLLEMRRRNAQFTAEKVDRRLKHATTTRGDLWDSVLADPPDGEPPMSRAEMVSNASAIVLAGSETSATTLSGCLWLLLTNPEYLQQLTERIRARFSTATVIDAQTVTQIQGLQAVLDESLRLYPAVPMQSNRIVPPPGARLAGSWVPGGTSVAVQQFAACRSPTNFHRPDEFIPERWEKEGEFINDRREASQPFSIGPRNCIGRQLALAEMRLILVHLLWHFDIELDRRRMENMDWMAVQGIWILWDKKPLWVVLKNRST
The following text describes a protein:
Function:
Forms a strong non-covalent specific complex with biotin.
Subcellular Localization:
Secreted.
Sequence:
MVHATSPLLLLLLLSLALVAPSLSARKCSLTGEWDNDLGSIMTIGAVNDNGEFDGTYITAVADNPGNITLSPLLGIQHKRASQPTFGFTVHWNFSESTSVFVGQCFVDRSGKEVLKTKWLQRLAVDDISDDWIATRVGNNDFTRQHTVEE
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MQGESVRAKMESLRLACAAEIAGEQREIDALASSFLESLQSAKAKARETVQNQGRLSKLKSSLQEAEDELVKALAVKTRTEAKRMAIMDSICAVKSRQENLRRSLQDQKARRDKCAAIVSQELIALTACEEKNEQRIGQKVDIQEAISWYNKVLGFQIEGGNGKCKHVGGTIIYLSCVIGLLTSVVIVGVKFMFNNIDIKNPHNVYFFTIRHANDTYTLLECDPPLDGTKELIHELNKSNDLYKFVRIMRRKFQEFATQGTSPSKTTVHQEYSINSLSAPVTSVSTEISESPARKKYYEIEYGEVERDIKKVNRGTSTRIATSSGSASSVRRSSRRLRNKD
The following text describes a protein:
Function:
Involved in formation and maintenance of cell shape.
Sequence:
MLKFFKNNKLIVVLCAIIVFIALIGLSIRSQSQSPPEQYIGDSVSFGQRVVSYPVNFVAGTIGDFFKKGDSKESKNKISQLESKNQQLEAENEKLKKELDLKDISKFDPISTTVLARNPDQWMNTIVIDKGSKSGITSNMAVMTSQGFVGRVTKVNKFSSQVDLISTNTRAGKLSVNIQHGSKNIFGLIDRYDEKNSELVISDINNRDNISKGDKVVTSGLADQLPSNLYIGEVTKVQNDQYGLAKEVRVKTGADLTDLSHVYVAKRDPKTIPDDESRDK
The following text describes a protein:
Function:
Catalyzes the synthesis of mevalonate. The specific precursor of all isoprenoid compounds present in plants.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAVEVLRRVPAPRGGAVGAQRREERARVQAGDALPLPIRHTNLIFSALFAASLAYLMRRWREKIRSSTPLHVVGLTEIFAICGLVASLIYLLSFFGIAFVQSVVSNSDDEEEDFLIASGAGCSQAPPPPAPAPCALLGSPGAGPEKMPAEDEDIVAEVVAGKIPSYVLETRLGDCRRAAGIRREALRRITGREIDGLPLDGFDYASILGQCCEMPVGYVQLPVGVAGPLVLDGRRLYVPMATTEGCLVASTNRGCKAIAESGGASSVVFRDGMTRAPVARFPSARRAAELKGFLENPANFDTLSVVFNRSSRFARLQGVKCAMAGRNLYMRFTCSTGDAMGMNMVSKGVQNVLDYLQDDFPDMDVVSISGNFCSDKKSAAVNWIEGRGKSVVCEAIIREEVVKKVLKTNVQSLVELNVIKNLAGSAVAGALGGFNAHASNIVTAIFIATGQDPAQNVESSQCITMLEAVNDGRDLHISVTMPSIEVGTVGGGTQLASQSACLDLLGVKGANRESPGSNARLLATVVAGAVLAGELSLISAQAAGHLVQSHMKYNRSSKDMSKAAC
The following text describes a protein:
Function:
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.
Sequence:
MASEAWRKTCSIPLRTSSLVYRSTTKPNPAHLSKIPQHSNHTLGMLHRRLFQATVCSIGHQPSANKSASLFRSLVPHRDSLRSSRPLKGWILRYQSNSACDHDAPNVPAVKLKRIEKEPKLNNLIKRIEPYLALSRVRAPIGAALLFLPCGSSLALAASSAAVSPQFLIAQTCLFGLGAFVMRGAGCTINDLWDRSIDQKVSRTQLRPLASGALSPANAIGWLGLQLSIGLAILLQLNIYSILLGASSLSLVIIYPLMKRITYWPQFVLGLAFNWGALLGSSAILGQTDWKVSIPLYVGHICWTIVYDTIYAQQDKKSDVLAGVKSTALLFGARPVPILAGFSTAFVGFTALSGFMNGCGIPFYSLAVIAPAIHLAHLLANLQPDSPSACHSSFIASAITGSLVWVGCLLDYCTRFFLI