lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MEAAAEPGNLAGIRHIILVLSGKGGVGKSTISTELALALRHAGKKVGILDVDLCGPSIPRMFGAQGRAVHQCDRGWAPVFLDREQSISLMSVGFLLEKPDEAVVWRGPKKNALIKQFVSDVAWGELDYLVVDTPPGTSDEHMATIEALRPYQPLGALVVTTPQAVSVGDVRRELTFCRKTGVRVMGVVENMSGFTCPHCTGWRGGAGPARRGALLRVCAPGPRAHEEPGGGPRLHPGVPREPHLRRTHLHSTEDSGRDAHMPPLTEAASKLPSRATEGSAPASRRNRAGSVPGPCRGRPRRRQRESSSLTSAAPGMYQAPAALPGWPVAERTARALVLWPGCPAAVRRGRLGLSSLPRFPPVPLAAARPHDWQSTGLPQSSGDPGPPAPWGHCHLREAGGALPKGAN
The following text describes a protein:
Function:
[[Thr6]-bradykinin]: Induces relaxation of rat smooth muscle from tail artery (EC(50)=16.8 nM) and contraction of that from ileum (EC(50)=205 nM), urinary bladder (EC(50)=895 nM) and uterus (EC(50)=60.3 nM). Binds to both bradykinin receptor B1 (BDKRB1) and B2 (BDKRB2); [Hyp3,Thr6]-bradykinin: Induces relaxation of rat smooth muscle from tail artery (EC(50)=56.7 nM) and contraction of that from ileum (EC(50)=588 nM), urinary bladder (EC(50)=4.6 uM) and uterus (EC(50)=3.9 nM). Binds to both bradykinin receptor B1 (BDKRB1) and B2 (BDKRB2). In arterial smooth muscle, the effect via BDKRB1 is stronger, in uterus, ileum and urinary bladder that via BDKRB2; [[Thr6]-bradykinyl-Val,Asp]: Induces relaxation of rat smooth muscle from tail artery (EC(50)=10.8 nM) and contraction of that from ileum (EC(50)=645 nM), urinary bladder (EC(50)=1.1 uM) and uterus (EC(50)=1.2 uM). Binds to both bradykinin receptor B1 (BDKRB1) and B2 (BDKRB2). Apart from uterus smooth muscle, the effect via B2 is stronger; [Hyp3,Thr6]-bradykinyl-Val,Asp: Induces relaxation of rat smooth muscle from tail artery (EC(50)=3.5 nM) and contraction of that from ileum (EC(50)=223 nM), urinary bladder (EC(50)=1.5 uM) and uterus (EC(50)=356 nM). Binds to both bradykinin receptor B1 (BDKRB1) and B2 (BDKRB2); the effects via B2 a stronger.
Subcellular Localization:
Secreted.
Sequence:
MSFLKKSLFLVLFLGLVSFSICEEEKRETEEEENEDEMDKESEEKRESPERPPGFTPFRVD
The following text describes a protein:
Function:
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
Subcellular Localization:
Cytoplasm. Nucleus. Secreted.
Sequence:
MILPKRFPWERGNGATATPSPSAMGRRPRGQAWGMRSREPPEGPPRDGRPRRLGPLSRSLLLCHAGTGEDSSSSEDKSAGPQKTQEGALSRPRTPSLDANPGASRDPPSLLYDEAACQPVRNPKRKLFVKLARVSTTSCSFLLLLLENSLWRSCIATETGRLEFRGSRTSSWASLRRDLDGSHGIRGGMAPRDGGEPLTLSDLSLNRLSSQEPGVFIQPAMGSVNWVIDDEETMSAASLEKPKDLESTGNSLPPRRPACLRPQTDSASFDSCWIGEHGDPEARPLSPGCGRPRKAWSQQFDCSGETQVTSRPSVSPSLAQLLPSRSSSQASVINNIVLMKGRAKGLGFSIVGGQDSMYGPIGIYVKTVFPGGAAAADGRLQEGDEVLELNGESMFGLTHQDALQKFKQAKKGLLTLTVRTSLGAPLSTSHWSSPPLCHSLSSGTSLPEETGPFCPETGPSPVHPAKPNDRIVVEVSLNKEAGVGLGIGLCSIPHLQGISGIFIHTLSPGSVAHMDGRLRCGDEILEINEASVHSLSLNQVHTILRRCPPGAVPVMVSRHPDPQVSEQQLQEAVAQAAGSGSGICKYGNHRNQWGREGARRLGSSWHGRFPWERQNEEITSPFHPRSQKTMTRSRSEDSYSLGEISGDRAPLRPTALKEGSPGLTDPRTPAPSPPTTVRQETCLPPTPKARRALEILVRKPRSTKPKPPPRKYFKVDAADAERPRPPSVDGETPRAEGGMPSSSSEGQEAGNLSPQGNQAAITHSVASTPSQAEAAEDNSASLGAVEEAKGSGPGPRLSPAARPRLRRQGRVTSVSVAEDPWVRISDCIRQLFSPAMSGGACPPDVTASLTTGPGRGSHSPPTPPEADAAVSKAYGSEASVRQKRAPPVAPKPAWFRQSLKDLRSGSLSLKPRPTPGQSSLTGAGGFPRPSSIRQKIHSFETCGDLGSAKPSPREGERPPRTPELPTVTGRPSPDGDDRQRRPPGPEPPGVTGPEDTRGSGSASPASPPDLGDSRARKVSGQRSRSFPLTGPRLGEVPKAALEEEEERQFGQLHSLSSRVSSALMRSLLCLPQSPGSGNPGGGGVSSPPSTGPPSEAPPLDSGFSLNLSELRDYSVGLADREVADQGVRGDDSPVAPSGGPGQSVISLLGPEEVKKLIEEVKGLDEATLKQLDNIHVTVLHKEEEAGLGFSLAGGVDLENKVVTVHRVFPNGLASQEGTIQRGDEVLSINGKSLKGVTHSDALGIVRWARGPRQAVIVTRKEGEAPRQRTAVPDSAPSGPGAASAEPGASTTTCVITLEKTSSGLGFSLEGGKGSLQGDKPLVVNRIFQGCTPEQSGGLQPGDEILQLNSTPLQGLTRFEAWNVIKALPEGQVCILIRRPGPGSGAEVPH
The following text describes a protein:
Function:
Non specific carboxylic ester hydrolase. Hydrolyzes various pNP-esters, with a preference for short carbon chain substrates. Can also hydrolyze tributyrin to di- and monobutyrin and 4-hydroxyphenylacetate to hydroquinone.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKSLPGVADLRLGANHPRMWTRRVQGTVVNVGVKVLPWIPTPAKRILSAGRSVIIDGNTLDPTLQLMLSTSRIFGVDGLAVDDDIVASRAHMRAICEAMPGPQIHVDVTDLSIPGPAGEIPARHYRPSGGGATPLLVFYHGGGWTLGDLDTHDALCRLTCRDADIQVLSIDYRLAPEHPAPAAVEDAYAAFVWAHEHASDEFGALPGRVAVGGDSAGGNLSAVVCQLARDKARYEGGPTPVLQWLLYPRTDFTAQTRSMGLFGNGFLLTKRDIDWFHTQYLRDSDVDPADPRLSPLLAESLSGLAPALIAVAGFDPLRDEGESYAKALRAAGTAVDLRYLGSLTHGFLNLFQLGGGSAAGTNELISALRAHLSRV
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MATSLAAQLAQIAAKSRSSLNVKAQKAAHTKSLIFEPRIAAGQSYQTIYTACRDGFEELCQLDARFTPFSNTLFSEQSQDEDRSQMTQAENKELDRRVDSFLRLVGSRLRLMPAIKAIEWLIRRFRIHEFNTSTLLATFLPYHSIPAFVTLLSILPADLPQQYKFLAPYVRSLTAPPRAAIVYQATHHREFLTAITEYTLDACRNKQQYPALVSFWAGVMTEAVNGRIDINRSGRQGVQLDNDLALIALVSKPLGDAMTMKDVPDIQIAAYMVVSLLAAKANFDDKLLSVFMEQLVIGWTAETVRPGLVCLSILAQYRAPKQLSSRVAKALLKMDDLPQRLVDASKQCRVDKLAYALVLALADRLAKKGDARGLPIIKSILLLELLQEKLGKVAFKSLLRAALKMTDEVDQDGSARKQLGSTLVLLSQSAGATGVMVRQVIEDEDYDIEGLELRLDTSFGPRRLLEDKPAEEDAKDLEVRQDPKETLEAAIERLAVPPRSVKSFLSQKSDQLFDDMCKVLLSVATDPDDLLKFDEAPFLCRQTAHDDSYYFSFYMRVWCGPYPTLIRSAALEMAKRRLKQGDCAALDLQAMIPYCVAALSDPAKKVRQAAADLITVLSKSNAEGIETAKRPIWASKQLYEQSNEQTWMNPAASRALLQEIIVPALEESVLDEEHISNVLRSHLQSTKDSATGPQLSSAVRLSIFSCITSHVVHTPLLAVKSRLLKPTNQVDSVSKATRTSLLLPLLRWWASLSSTEAAQLCERERIDESKFNQSCVNVAVANDKPGLETLFEIITNSSAWTREGLVEAAFARTRKIWSTIKSDSKLKLALSMLDLAQTPATAGSSAEFVSEEAADFLRNVDLTTNILNAFLESLQDIPKITTDSPATKRRRTSSSDHSRGVSLQATNAVKAALNKVTFVLQLVEGSKPAEHPELLQSLFVTLADLQVLRSQVGSELGYLQNLVLSSLLAMMPTYKNNKSLKIDTSVGHGDVLVQCIQKSSSPAVQNSALLLVASLANTAPDVVLHSVMPIFTFMGGSVLRQSDDYSAHVVVQTIKEVIPPLVETFRKSRRNLVTSAAELLSSFVIAYEHIPSHRKRDMFISLIENLGPKDFLAALVAMFVDKYGTTDSMVAFCKDLMNSFGVEVQLQSLVMLLDLVSDCLQPKPTLAATLFNRNTDDDQDLHKTALKELTLLPKVLSSRQLRTEVSQLAGRDDMEASKFRELYASLLEKILTLAETVKTNKALHARCSDTLAGLLNLLSIGEFIKAVENLLDRPSISLRQKVLRTLEVRVDQESNTDADSRTVLLAFLPQLTAVIRDSDDIAYKHTAVACVDKIAEKYGKKDLEAVAAAATTIAGDCCLGQPDKRLRVMALLCLASLVDVLQDGIVPTLPVSLPKALSYLSESLQGEKEPELHNAVYSFFESLAVHVPYMLTKTYIGQLLAVSNVSAEANMSDESSQARFGCLQLLANQVDANTMLAALEQNWAQAVNAGFSAVEEYLKLLATVLDKHPSTIIAKHISTLSTIFLSALDLRRNVQSKDTVSIAALAKLTEIEALINDVALKMIYKLNDSKFRTVFTQLMEWVATGLPKDDKLGKVLRHQSVYSFLLAFFDNLKDVVASYASYIIDDATAILKASDPSKMEDRELWQLVLKTLARCFEHDSGGFWQVPAHFEAVSGLLVEQLEHAAALGELPGGDLVQNAVVGLAEAAASRDHRKELNAAVLRRLRSPSASVRLAAVRCEQSLTDTLGEDWLEMLSEMLPYISELQDDDDEDVEKETHRWITKIEAILGESLDAMLQ
The following text describes a protein:
Function:
Probable transcription factor which is required for asymmetric division of vulval blast cells. Involved in olfactory plasticity probably by regulating the expression of transcription factor mbr-1 in RIF neurons. Plays a role in the chemorepulsive response toward ascaroside pheromones mediated by the ADL sensory neurons, probably by regulating E-box motif 5'-CANNTG-3' containing target genes in the ADL neurons. Plays a role in the differentiation of the ADL sensory neurons.
Subcellular Localization:
Nucleus.
Sequence:
MHSSSSFIITSLEEEEKKPPAHHLHQQSIEDVGSVTSSATLLLLDSATWMMPSSTTQPHISEISGNECAACAQPILDRYVFTVLGKCWHQSCLRCCDCRAPMSMTCFSRDGLILCKTDFSRRYSQRCAGCDGKLEKEDLVRRARDKVFHIRCFQCSVCQRLLDTGDQLYIMEGNRFVCQSDFQTATKTSTPTSIHRPVSNGSECNSDVEEDNVDACDEVGLDDGEGDCGKDNSDDSNSAKRRGPRTTIKAKQLETLKNAFAATPKPTRHIREQLAAETGLNMRVIQVWFQNRRSKERRMKQLRFGGYRQSRRPRRDDIVDMFPNDQQFYPPPPPSNVQFFCDPYTTSPNNPETIQMAPQFAVPTENMNMVPEPYTEQSATPPEFNEDTFACIYSTDLGKPTPVSW
The following text describes a protein:
Function:
Probable transcription factor required for the flowering response to vernalization in the shoot apical meristem (SAM). Defines the competence of shoot meristems to flower in response to vernalization in perennials.
Subcellular Localization:
Nucleus.
Domain:
The SBP-type zinc finger is required for the binding to DNA.
Sequence:
MELLKGSGLNQTESGGSSSTESSSLSGGLRFGQKIYFEDGSGSGSGSSKNRVHNTGRKSLTARCQVEGCRMDLTNAKSYYSRHKVCCIHSKSSKVIVSGLPQRFCQQCSRFHLLSEFDLEKRSCRRRLACHNERRRKPQATTSLLSSRYARTAPSLYGNANSAMIRSVLGDPTAWATARSAMRWSGPERESHQVMNVFSSHGSSSFTTTCPEMMMNNNGTDSSCALSLLSNTNPNQQLQQHQLQTPTNVWRPSSGFNPVIADRVTMAQPPPVSIHNQYLNNQTWEFTTGEKSNLQYMSPVLGPSQISQPADFQISNGSTMGGFELSHHQQVLRQYMEPENTRAYDSSPQHFNWSL
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSGFSSGNVNSRVVDILSGVVPLLKLICLTVIGLLLAHPKTQLVPRATFRLLSKLVFALFLPCLIFTELGESITLDNIVQWWFIPVNVLLSAVVGSLIGYLVVLICRPPPEFNRFTIVMTAFGNTGNLLLAIVSSVCHTKTNPFGPNCNSRGVSYVSFAQWVAVILVYTVVYHMMEPPLEYYEVVEEEGVEIEEINVENHDASRPLLVEAEWPGIEDKETEHCKTPFIARVFNSISSFSQTSFPEVDLGGEYGGESSSPRSIQCLAEPRVMRRIRVVAEQTPVKHILQPPTIASLLAIIIGSVPQLKSVVFGYDAPLSFITDSLNIMGSAMVPSVMLVLGGMLSEGPNESTLGLRTTIGISVARLLVLPLVGIGIVMSADKLGLISSADPMFKFVLLLQYSTPSAILLGAIASLRGYAVREASALLFWQHIFALLSLTFYIVIFFKLTVETTVQGMQ
The following text describes a protein:
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MVNLRKKFEMKQANQPGRVPNYFRNKYHGYDDDMPNLLPTFIKLLDTEKDEDGAGLNAAEQIDRELKSRKCDILKFRNLTILELPHLNEFLFSTELNPPISDQVRHRDMNAPLSHYFIHTSLKSYFTGNNVFGRLYSIEPIIDALKQGVRVVELDLLPFGKDGICVRPKWNFEKPLELQECLDAIKQHAFTPTRSYPVIITIKDSLKPDLQSKVTQMIDQTFGDMVYHEDPQQSLEEFPSPAELQNKILISRRPPTKLLYAKAVENGVELEIQEGSTDKNYQSVVGFHAVEPRGMLQKALTDDVQQPGWYERDVISFTQNKFLRTRPKKRNLLSNPPYKPQRAWMHGAQMIALSRQDDKEKLWLMQGMFRANGGCGYVKKPNFLLNAGSSGVFYPTENPVVVKTLKVKIYMGDGWIVDFKKRIGRLSKPDLYVRISIAGVPHDEKIMNTTVKNNEWKPTWGEEFTFPLTYPDLALISFEVYDYEVSTPDYFCGQTCLPVSELIEGIRAVPLYDERGKACSSTMLLTRFKWS
The following text describes a protein:
Function:
Involved in resistance toward heavy metals.
Subcellular Localization:
Cytoplasm.
Sequence:
MLDVKSQDISIPEAVVVLCTAPDEATAQDLAAKVLAEKLAACATLLPGATSLYYWEGKLEQEYEVQMILKTTVSHQQALIDCLKSHHPYQTPELLVLPVTHGDTDYLSWLNASLR
The following text describes a protein:
Function:
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).
Subcellular Localization:
Secreted.
Sequence:
MKFLALALTILLAAGTQAFPMQADAPSQLEHVKAALSMYIAQVKLTAQRSIDLLDDTEYKEYKMQLTQSLDNLQQYADATSQSLAPYSEAFGTQLTDATAAVRAEVMKDVEELRSQLEPKRAELKEVLDKHIDEYRKKLEPLIKEHIELRRTEMEAFRAKMEPIVEELRAKVAINVEETKTKLMPIVEIVRAKLTERLEELRTLAAPYAEEYKEQMIKAVGEVREKVSPLSEDFKGQVGPAAEQAKQKLLAFYETISQAMKA
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MIGKVVVSAISLILVVGIVIGVVASVHRSTTKTVETPQMKAVTQICQPTNYKETCTEALSSANTTDPKELIKAGILAISDSLSKSLKLSQGLVGEAVSEPRTKLALQDCNTLLKNASDGIEDILTRMAESQLQSIAEHADDFRIWLSSIISYQELCMDGFQHNGDIKSTVQNSTDYGNKLTDNVLTILAAISNILQDFGLQFNPPKNSRRLLGADGYPTWLTAGHRKLMAGAGPAPNAVVAQDGSGQFKSISAAINSYRPGSSARFVVHVKAGTYNEQILVPKTHSNVFMYGDGPDKTIITGKKSFASGVNTFNTAPFVVEGPGFICKNMGFQNTAGPSGHQACSIRVNSDMSVFHNCKFDGYQDTLLYQAGRQYYGNCVITGTVDFLFGYGAAVIQNSQIIVRKPNKGQKNTVTADGRKEKGQNTGLVIHNCKIIPEPQLVPERLTVKTYLGRPWKQFSTTVVMQTELGDLIQPEGWMPWDGNLFLNTIFYAEYANTGAGANTANRVKWKTLHFLNPVEAQRFTVGTFLPGSGQWIKTAGVPFLLGFR
The following text describes a protein:
Function:
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (By similarity). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (By similarity).
Subcellular Localization:
Cytoplasm. Postsynaptic density. Cell projection, axon. Cell projection, dendrite.
Sequence:
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFTDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQQQILPGDRKPLYHYGRGINPADKPAWAREVEERARMNKQQNSPLAKAKPSSAGPEPPISQASPSPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAAVPTPTATPSARGAVIRQNSDPTSEGPGPSPNPPSWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRNRVGASTKLDSSPVLSPGNKAKPEDHRSRPGRPASYKRAIGEDFVLLKERTLDEAPKPPKKAMDYSSSSEEVESSEEEEEEGDGEPSEGSRDTPGGRSDGDTDSVSTMVVHDVEEISGTQPSYGGGTMVVQRTPEEERSLLLADSNGYTNLPDVVQPSHSPTENSKGQSPPTKDGGSDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDTIPITALVGGEGGRLDQLQFDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
The following text describes a protein:
Function:
Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLRSNFLRLMAHGAPSRLMSTATKLTTVEINDKTGIATLTMNRPPVNSQNVQLLLDLQTSISEIENNKSRGLILTSASSNVFSAGLDIFEMYNTDVERLRTVWTELQNVWIALYGTTLPTAAAINGHAPAGGCLLATACEYRVMRPNFLIGLNEAQLGIIAPKWLMSGFASILPKRVAERALTQGRMFTTQEAFEVGLIDEIASSKEEALEKCAAFIGTFAKVNPLARGLTKLQFRGDNIKEFEMIREKDIADFVALASSPGVQKVMGAYLENLKNKVKK
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MLDPTPNGLHSGESPLLQTLGLTKRYGDFLANDSIDIDIWPKEIHALLGENGAGKSTLVKAIYGLIQPSAGEIRWQGERIVLSGPSEARSRGIGMVFQHFSLFDNLTVAENVALGLDGKESFKDMSARLEQVSKTYGLPLDPRREVWQLSVGERQRIEIVRALMQDPKFLILDEPTAVLTPQEADQLFIVLERLRAEGRAILYISHKLEEVKRLCDTATILRGGRKVDTCNPRLETAASLARMMVGGEIKEVKAPAGRKTTVPRLVVNDLSLAPSEAHGVRLEHISFELKGGEILGIAGVAGNGQDELFAALSGERLSKDPGTVVIEGIAAGHLSITQRRKLGAAFVPEERLGHGTAPRMKLSENALLTGHAASGMVHRGFIDTAATLKTVDRATETFDVRKAKRDPEAASLSGGNLQKFIVGREILRNPAVLVVSQPTWGVDAGAAAVIRQALLDLATAGAAVLVTSQDLDELAEIADRIAVMFHGHLSAPLATSEATREKLGLLMGGSSLEPKEAAHAVGA
The following text describes a protein:
Function:
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Subcellular Localization:
Cytoplasm.
Sequence:
MDDELRERVRRAAERAALFNALKHGSDAQVGAIMGPMMGEHPDFRAHGDEIPGVIAPVIEDVNGMSDDEQRARLAELAPEDVEELDSEDEGDDHALPALPNAEAYDEVRMRCAPNPNGPWHVGHARMPSVIGTYKQRYDGSFVVRFDDTDPETKRPDLDAYDQILEDLSYLGFEADEVLTASDRVETYYEHARRLIGMGGAYTCSCPGAEFSDLKNSGEACPHRDKDPETVADEFEAMVDGEYNSGEMVLRVKTDITHKNPALRDWVAFRMVDTPHPRDAASGYRCWPMLDFQSGVDDHRTGVTHIIRGIDLQDSAKRQRFLYEYFGWEYPEVVHWGHVQLDAYDVAMSTSTIKERIAAGELEGWDDPRAPTMQSIRRRGIRGAAVVDAMVELGTSSSDVELAMSAVYANNRDLVDDTAPRQFLVRDGFEARGEGPEESHEAVEVPVDDGPDEATPQVHPEHPDRGDREIPVGERVLVEATDLPAAGDRVWLKGYGPVRYDGERFAFLDADIDIVREEGVDVVQWVPAEHNVDVRLRTMDGDVTGYAEPGFADRDADEIVQFVRVGFARVDAHRDGGASVAYFTHP
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated sequences, including transposable elements. Required for RNA silencing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSTLKFCRECNNMLYPREDKETRTLLYACQSCEHEEIATDTCVYKRVIRKPVGEPKDVLKDAATDPSLPRTRSVRCYNCNHPEAAFFQAPTSGEQAMTLYFICCNPSCGHRWRD
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSLSPEELLDIAWEEKSDEHMTPESPVDHSDAHLVSEDSPPPPCPDCGRTFQTLRAHNLHRRNHAADLSYTCKDCDVARAGAIGGSDKPYSCSDCGRRFCWLLALHSHHEQQHTGQCGYQCSQCGKKLPSQPAFRRHQQGHRKDRVCVWCGKAFNCSAKLSRHMRIHTGERPYQCQECPKAFTQLETLRVHQWVHEDPKPYQCQECGRRFRGQRTFEKHRNLHISRKPHACPVCGKTFFFSSRYKRHLRIHTGERPFLCQQCGKSFNQRSNYQRHRLIHAGKRPFPCNLCDKSFSQASNYRRHLQTHKRERGVWGEEEDEEEEEGDYTCTECGRRFTQEGSLHKHYIQHARGEL
The following text describes a protein:
Function:
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. KAS III catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.
Sequence:
MHLGFVSLRSESDTEGTTFYRFLPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLPILGFAFRAKISKRVFCSSTIEGAEKLSPSQSRVPRIVSKGCKLVGCGSAVPSLQISNDDLAKIVETSDEWISVRTGIHNRRVLSGKDSLTALAVEAAKRALEMAQVDPDEVDLVLMCTSTPEDLFGSAPQIQKALGCKKNPLAYDITAACSGFVLGLVSAACHIRGGGFHNVLVIGADALSRYVDWTDRGTCILFGDAAGAILVQACDSEQDGLFAFDLHSDGDGQRHLNASMKNNETDSTLGSNGSVLDVPQARSSYSCIQMNGKEVFRFAVRCVPQSIESALEKAGLSGSNIDWLLLHQANQRIIDAVAMRLEVPPERVISNLAQYGNTSAASIPLALDEAVRSGKVQSGHTIATAGFGAGLTWGSAIVRWG
The following text describes a protein:
Function:
May function in the process of apoptosis.
Sequence:
MPGRCGRLRSGEGRARAPRGSRSSEWAKAWLRLLARDGRTMAEEELEALRKQRLAELQAKHGDPGDAAQQEAKHREAEMRNSILAQVLDQSARARLSNLALVKPEKTKAVENYLIQMARYGQLSGKVSEQGLIEILEKVSQQTEKKTTVKFNRRKVMDSDEDDDY
The following text describes a protein:
Function:
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
Subcellular Localization:
Mitochondrion.
Sequence:
MPSICPKSAMISLPTVLQSIFAFEVAPQIRNSSVRSLNRSSLRHRLRSTRTITTVSIDSIPVPSAQKPDDRVTSPSEPSLTADKSTASDTSSSNPASKATSADNSGSARRTKTNTKTSNEKQASDHENKKNIKKSAKETTASNAPKPPKEKEPWQIQKEALKRKFPTGWAPPKKLSPDAMEGIRHLHHIAPDQFTTPVLAEEFKVSPEAIRRILKSKWRPSGEELEERRKRWEKRHDRIWSHLSELGLRPKVPDYGSDADAVLYKRKSKGV
The following text describes a protein:
Function:
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism.
Sequence:
MQSFKSASILRRLLQNSRLVSHSRSFCSVSTNALVDESQSTVLVEGKASSRTAILNRPHALNALNFSVVDRLLKLYKNWEDDPDIGFVVLKGSGKAFSAGGDIVTIYNLLKQDAGNLQDCKDFCWTINNLVYVVGTLLKPHVALLNGITMGGGAGISIPGTFRVATEKTEIKNLSNLIVKEVYQIWPVHEVFATPETLIGYHPDAGASFYLSHLPGYLGEYLALTGDKINGAEMISCGLATHYLHSAKLPLIEEQLGKLMTDDPSVIERSLENCGEIVHPDPTSVLHRIETLNKCFSHDTVEEIIDALESEAAKKQDAWCVSTLRKLQETAPLSLKVSLRSIREGRHQTLDQCLIREYRMSVQAFSGQITNDFCEGVRARLVDRDFAPKWDPPSLDKVTDDMVDQYFSRLTAFEPELELPTQQREAFT
The following text describes a protein:
Function:
May be involved in the metabolism of 1-methylnicotinamide (MNA). Linked to regulation of longevity through generation of reactive oxygen species, where it probably functions in a pathway downstream of the sirtuin sir-2.1 and the nicotinamide N-methyltransferase anmt-1.
Sequence:
MPLTGIFFNVNGKDVNEENVDPELTLAYYLRNKLGLRGTKLGCEEGVCGSCTVVLGTWDDCQNKAVYRAVNACLVPLFHVHKTFVITVEGVGSRDKIHPIQDRMARGHALQCGFCSPGFVMSAYALFSNQPNPTIQQINAAIRANLCRCTGYRPILEALYSFSSESGGCCGGNKTGGGCCKDKSSSDEDGGYDEKLLSFNDFPKYDPTQEIIFPPSLRVFSDSETPVTLKGDRIELLLPKNIDQFKKFKKDRTVISSGLITRFVSTRNPKEFSQKWISTKYVKEFNEITVNKDSVVVGAALNIQKMADTLTSSLSINIGKEIDSFIQKFSSPQIANFATWTGAIISGAKSSLSVSDLLILFNVLDAKLTLLNNSGELTQVAIEEFAEKKLFATHTIVNAIFSRSLTGFLFCLKLGETSEQDSTNFNFAALVGNQVSRIFVGLGGQPKRLTSLEVHIDALKGLSVSDLCQTTEMSDYKNVKIALTRFSDFMNHKEKTEEIEGINYLQYFKPKTNESAGRPIANYFNERAITGEAFYVNDIQAYNAVHLGFVLSTVPHAEITKIDVSEALQLEGVAGYFGVSDVPGNNTPGLQISNMNFPDDTTIFADKKVESVGQVIGVIAANDVVLARRAAKLVKVEYKELPSLVNFKEAIEAKSLLGDVQHFGKDENLVKESLENSSKVLEGECDIGGQEHYYLETQSSLVIPGEGDELIVNCSTQGTSFTQLMVAETMKIPAHKIIVKTKRLGGGFGGKVNNASWIACMCAIVAKKLNRPTYGFLSRADDLAITGKRHEVHAKYRVGINFDGKIEGIHYQAWLNGGWSKDHSEGVTMVMGLMVDDVYNMGTIRFDGYPVKTNSNSNTALRGYGNPQSKLINEGVMRRIARDVGKSTEEIKRINFALEGGRRYLGGKIHNDALVECWEYCKKWSEFENRQSGIKQFNKNSTAVKRGIAMSSVRFGLPHPGPTGHGIASLLINLDGSVQLSIGGTEMGQGLNQKMLQVCSEALKRPIDTITIVDCSTDKVTNAPETGGSQNADTNGLAVLACCKKIMSRLQPIIDKNDGEWEKSIREAYGAYVPLQCTEYGTVERAKFGVGEMESPYNTTGACAVEMEIDTLTGYNRVIRVDIVMDVGESLNPALDIGQIEGAFIQGYGLVTCEKITFNKTTGQLDQNTAGKYKIPKASDVPKDFRVKLLGINNANGAQVYSSKGIGEPPLMMSCGAVHSSIMNCIDNWRNENGIHEFVDTISPLSAEKIQELCSKK
The following text describes a protein:
Function:
Class III viral fusion protein. Envelope phosphoglycoprotein which mediates the fusion of viral and host endosomal membranes leading to virus entry into the host cell. After receptor-mediated internalization of the virus, gp64 undergoes conformational change into a fusion-competent state at low pH, and the nucleocapsid is released into the cytoplasm after cell fusion. May also play role in budding.
Subcellular Localization:
Virion membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein.
Sequence:
MVSAIVLYVLLAAAAHSAFAAEHCNAQMKTGPYKIKNLDITPPKETLQKDVEITIVETDYNENVIIGYKGYYQAYAYNGGSLDPNTRVEETMKTLNVGKEDLLMWSIRQQCEVGEELIDRWGSDSDDCFRDNEGRGQWVKGKELVKRQNNNHFAHHTCNKSWRCGISTSKMYSRLECQDDTDECQVYILDAEGNPINVTVDTVLHRDGVSMILKQKSTFTTRQIKAACLLIKDDKNNPESVTREHCLIDNDIYDLSKNTWNCKFNRCIKRKVEHRVKKRPPTWRHNVRAKYTEGDTATKGDLMHIQEELMYENDLLKMNIELMHAHINKLNNMLHDLIVSVAKVDERLIGNLMNNSVSSTFLSDDTFLLMPCTNPPAHTSNCYNNSIYKEGRWVANTDSSQCIDFSNYKELAIDDDVEFWIPTIGNTTYHDSWKDASGWSFIAQQKSNLITTMENTKFGGVGTSLSDITSMAEGELAAKLTSFMFGHVVNFVIILIVILFLYCMIRNRNRQY
The following text describes a protein:
Function:
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular Localization:
Cell membrane, sarcolemma; Single-pass membrane protein. Cytoplasm, cytoskeleton.
Sequence:
MKFLNLIVVVLALICNEVQGLKLQANVGELFTYKIEPQLFNWTHQVISQQFRYRPSLKNYPDLPSWMRYMYSHEYHAGFLYGTPPASSAGKDLSLDVVALNRQNYETRRVVVTMFVAHKFPTPNVVQMKINNLNWVHLMDPGRRENLRNIFRNDLWPNSKEDLSVVFMESAVNMGGRLPLRPQQREGVIVHVGSFAQFSPRLQELQEEVRPLYKLPSCTYKRTSVQKIFENVGFKLDWCAFRMVGMESPTEILFHSGKQNEQQMPDDLNQRQEDRWMGIAREDVPERNYIDEFAFAFAIPGMIFAILIGMLSAVLCFQHEKFYDPHSEFFFANIFHICEESCAPQSASSDSGADDGSESSSNSDYPMASTVQMVQCSDSKSNQPITTLKSLKDPNFLLDNTSMRSQSPNNSFYQLDCGNSSIYARPKPPPYKGGTLGRNGVDI