lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.
Subcellular Localization:
Nucleus.
Sequence:
MSSFIPLNALEDYSLSSAEEHTRELQIEEGLKIFQKALHAQRQGKLDEAFDLYDALFKIDVIHLDIDDNNLSPTVGRLKYLAYKNHGILLLEHLAHNLDDLTTTEIRDQLQDILVQFADALLVDDSDDSFLKLFSDLARIIGLKRLSRFALECIVSSPSRVFTFSESLLNHDFLNPEEVAILQEVVLLAKQLQDYVSMDSPMYDLMASQVADVAPAKKPKYISWIEPTQFKAPPLKDLKETWRGSELVVEIGVPSWRGICKGLHDSLHRLTKRKKVLNGVTIRDPYLQIGVEISSVHGKLVDEEDLEDPEDDVEMMDIIDKPAEETIEVKTEEALDSTVKVEEIPAEINIGEVENKSSTEENKKQESPENGDKKEASGNGNGSAGPPVKDTTVKTEDRDSLTVALAIKRPAEGTTSSSQPPSKRTRGRGADEPAELEKQVDPGFFNNITSFVGSLDLKFPFVDLNQLDNEEQFYQDFKAVISNWGEQGSELFLKLSSAPESNLSVPVTQILDSAAQVDDDYGAPCNVLSISPDKFLEQMSESCSLSDFRFKIIEALLGNSSLVNEIWPSELIASVQIILNHLEPQILRDVRQMFFDGQTHSDSLIKQQLYVAEARYELVANEIIADKQRITENTSKLTKSALRDREWHKKTLHQRLLAWESCVITLLSMCKTRQLSVTELELRHTWVRLSLSQCDEAEISRMRQNYEEFQVQLLDEAPDLMVRFVNFPHIQTLSLDSVNGQISKLKVASTFAKIFSPDADEDIGTRIAMLESILKGSSDTSGDRESLSAREFLQHASIDFKHKLWYLLLDAYNESGEKRISVDGYIEMLTSLSYELETAGYRNMNPNQRHTILLRTLSTMNDTVGNLAKICRDTPALLESVSREKIHELAQLCLSFLRLLQVFNQFYDRRNPEEPTPFLWDKASEKFQTMMVKLWTFFYLLFRQLTNGLDENLPQTTISTLNDILSIVHEDLGHRKCCSFANGIFVDLTLDEIVRMKWNESEADLLQNIRCRFGIQLANEHYHPTDHGATPRALKRSDGLAFQDFIMNMVYRKPSSVHNIRADLRAVMDQLYEAIGDPDKNIASTSHNMTVLGRFTVAPVTWNYIENSLRGESFLPFMTSTDPVLSASTGGFYCVQGMLALAKFRQGKKAAAPGRTEDLQAAVKFFTNDILCCPTRYESWFGIANAYEMLTEDDLMWSAEKLDVPNSIVNINQRKALLCGLNSVNLMLQQRDEKPANPQLRTFFNAVMKESQWLFLSKLFYSATANPLHGASFRQADNKIFCGMKGLYMRQNLSLPRRKQCYQVVRACLTISINSKDQPPDWYSYYLRSKVYSKLKKTTQAILGDIQKSIAVAPDKINGDILLEPHYKLVAYLYKAVKRGKLTAAEAYKELKKTPHFVEYLGEDADMESGDDSDSDSEVGSDSETESTKEGPIASATEPAADTAPPVVPSEGTSGSPISIDDATPVPGPVTAVTAIAAPPTVAAKPEEKKKPLTRMEIKFYKSCIETLRRMKVLDKRKWHHRPPFLIARIHKEVFEDYRSAKEEMVPFFNLKNQSKAPVHIWKPDFERAGKHFQYVFDYLMFFIVLLDKTDDTDAITTIGKKLRRFNNGMVNHFEVWEFTCLTSNVLMKRVTRIPEKLPDAIIPSLQFDNFDRIAQGLQDKITKSKEPASYLLSLLYYASEFRRLNNGFGSTGVVDDTVVCLYLKMLIEYAGTSLLADNKSRSSTPVVLDGAKFEFQPGSAQPPALPAPATTATTAGKKEDGKKEKTRVTRKDILLRATNLIKACSNKVGENIKLVTTKGPPAVASSNGSSSNSGTRSNSEEKEKEPTEEPEKSTQDSDVEMADANQGNTETTVEPEAEGEADKSAEEDKSDKSAEEEKTDKFAEEEKSASAEPAGKNTPKSKSTGSNGVITIDEEYSAPE
The following text describes a protein:
Function:
Involved in the negative control of telomere length and in telomeric silencing through a replication-mediated pathway. May have a role in Okazaki fragment maturation. Required for S-phase progression. Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re-start, recombination and repair.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MKRHVSLSDILTGNKRKVRRQDALQITIDDENDTESGTFDARTAKHDDSSVIFLNHSVVKPIEAVSTNHKSAKEFLMTKRTKEKCDDDDDDLIVISDKSPKSETNCSKIALSQEHEDDISIISTSRIKSSLLNERASKIKNFLKHETTDTFKRLNSISKLNEIEPPLPLHQSIFPVGDKELSDRSVDIPLPFRTIPPLNHNFLPSDYESLKDKNSASCIPVRYQAPVLLGTNIKRNTTLTWPQLFKPVTLKQVLIEPKLKLRIKNWIETSFHTLEKPTLRNRLLNRINPNKQQGSGDELANFIVPDLEEDENLRPDFYRNGEANSSLSEFVPLMILHGNSIGKKTLIQTIMREIAGDDNSYQIYEVNSNMNRSKKDLLDILLDFTTTHYVKDSSKRKSDYGLVLFNDVDVLFKEHDRGYWAMISKLCEFSRRPLVLTCKDLSLVPSELIALASEQNSLFHTKKISTSTVYAFLTKYLKSLEIEVCDDWLRDVVKQNNADIRKCLMHLQFWCVDTEADLISSKNRLPVLTSTLGSSVKDISQLTDLLSINDVIGQATLNRSMVRQEIDSTTMTPEKVNTFQDQNLDDEMKLKFDYVIDYKLHLNDPNRQPLLPFELNIYQHIQEQLEARYSYVREANHRLDNEYLVNRFKKMTESTLNFLASRIPKYDHLQSARRTRNSKKISDILNQFKGIYNDETLNENAEIDLLSATTQQIKAEINPFVFEIAKSDANVKNENKQIFELHSENVSERRYKDLVYQLSQEGVLKNVWFNADPSIVVRKWEHLHSGFSKNK
The following text describes a protein:
Function:
Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
Sequence:
KYVFKMEMTCEGCSNAAKRVLGRIGVDDVVADLKEQKLFVTTDKSSKEVLETLQKTGKKVEMMN
The following text describes a protein:
Function:
Functions as a receptor binding protein (RBP) and probably mediates the attachment to the host capsular exopolysaccharides (Probable). Displays a depolymerase activity that specifically degrades the K25-type polysaccharides of Klebsiella pneumoniae capsule.
Subcellular Localization:
Virion. Note=Tail appendage.
Sequence:
MGNFIQPKGSTSTEIAREILSKTYSINYSEIDFIKQNLSVNGLKLLIDPNTQYIWGTISSLETGTISSWSIDSTGEIMTVLTTNGTLTLRKISVSTSTTTANSIYNFMTSDDIYNIKNVVGIEINVDYALQKAINSGLMSIYYPPSKGIYVHSNVCTLPSGFNMYGQSRKPYTVSNDASFNNCGTVIRLASGSPGIFVLSGRHTFDNIVFDGRNNTVGSMNATSQVSGCRFEKCGFYRWGIGLGRTSGYVATVYARGCNFSGNNTAMQDWIDSRAVDCTINAQVSRGIAMRTGANNNAWVGCRVEWNGTDGFYFYQSVGNVITGELIDRNGYAGITVADGASVSVTTCSIQRNGRISSNTNNGANILINDSGIILLNGNRFTSGVDDGGTGVLTPDYDIICAGGTGKILIASGNSFSGGNLGYMKEVTIANKVITGNYGLPDIVNTGTYQKSSGLVKMGNTSTGTLPPAASNGTLTLSLSRPAMTQYMIPQKIVLEISARDTIGGRAEYFTVPLLCSWESTVPVINMISSKLDTYPDNVWGPSTNTPTGVQVSVSTTSDGSTITINLVSMDTRNRQIQAYIRGA
The following text describes a protein:
Function:
Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
Sequence:
MQVFSEADGEFVSGQTISDKLGCSRTAVWKHMEDLRSEGYELEAVRRLGYRIASKPDKVTANEIQLGLQTKRIGRTVYFEETVESTQHIAAKLAYEGAEEGTVVVAEEQTAGRGRLSRKWHSPKGTGIWMSIILRPSIPVHHAPQLTLLAAVSVAQAIEKCTGVNVGIKWPNDILIQGKKAVGILTEMQADLDKINAVIMGIGINANQKQEHFDEEIQHIATSLAIESGKPIVRAELMQQIYLQLEKLYEEYLQNGFSVIKILWESYAVSIGKEITARTMRETITGLAKGITEDGVLLLEDHEGKVHHIHSADIEIK
The following text describes a protein:
Function:
Probably involved in nervous system development and function.
Sequence:
MAALASSLIRQKREVREPGGSRPVSAQRRVCPRGTKSLCQKQLLILLSKVRLCGGRPARPDRGPEPQLKGIVTKLFCRQGFYLQANPDGSIQGTPEDTSSFTHFNLIPVGLRVVTIQSAKLGHYMAMNAEGLLYSSPHFTAECRFKECVFENYYVLYASALYRQRRSGRAWYLGLDKEGQVMKGNRVKKTKAAAHFLPKLLEVAMYQEPSLHSVPEASPSSPPAP
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MAEDKSANKLFLRWLREWYQDASDKDSKMRFVYKKAIKSLSSYPPPITDVHALKQLQNFGVKLCKSLGEKLQQYLDEGNTLPTHSVNPVKKATPPIPKTSAKQRPISKSNRPSKTQTKQPLKKKADTARQRRADRKTSVEPDDDNANQDLASTSSDEILFSTGIDQSSGRKHRNTARKSCPINLDDFYTSLKYWYIDENKNTVMARKKSKLIFNDAGQKLYTIKTTFSQLVSSKVKYRLDENQDQSNDSEFIIAYLHHDYASELCNPPRELCNLPRDSTYDSRAVEFGSRETTTSSRKCAFKLQPDFIYDKRKLHLGDFLWVAKDKNSDRELVIDCIVERKSMDDLGSSIKDGRYHEQKVVDDFAVWVTQSWKETAEFIAALTKSLQHMYRGKTLYCAADQCDVAYADDYLPTFEMFNKRFVKNKKMTVKEAFVKLLLPISGASPDKAFAIVNVYPTVNQNIGHALSKSIYLFFNTVATS
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MSSLYYANALFSKYPASSSVFATGAFPEQTSCAFASNPQRPGYGAGSGASFAASMQGLYPGGGGMAGQSAAGVYAAGYGLEPSSFNMHCAPFEQNLSGVCPGDSAKAAGAKEQRDSDLAAESNFRIYPWMRSSGTDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKTAGPGTTGQDRAEAEEEEEE
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1) (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Domain:
The J domain is essential for co-chaperone activity and mediates the heterodimerization with the J-like domain of PAM16.
Sequence:
MAPLEAPILAIPGENNTHQQQQQQFQYTGQLQKKKAAEGSIEWYFDQTINFMGDHPVITGIGAFAVAYFAAGFIKSNQPGINGKAFVKGGFGAKMTAKEALQILNLKETNLSKLKLKEQHRKLMMANHPDKGGSSYIATKINEAKDFLDKRGGMKPK
The following text describes a protein:
Function:
Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It prefers glucosamine 6-phosphate or dopamine. It can also use the thialysine, N(8)-acetylspermidine, chloramphenicol, puromycin, polymyxin B, and 4-aminobutyrate ethyl ester.
Sequence:
MNFVLSDVADAEAEKAIRDPLVAYNLARFGESDKRDLNITIRNDDNSVTGGLVGHTARGWLYVQLLFVPEAMRGQGIAPKLLAMAEEEARKRGCMGAYIDTMNPDALRTYERYGFTKIGSLGPLSSGQSITWLEKRF
The following text describes a protein:
Function:
Lipid particle-localized triacylglycerol (TAG) lipase. The lipid droplet/particle is a lipid storage compartment which serves as a depot of energy and building blocks for membrane lipid biosynthesis. Involved in the mobilization of the non-polar storage lipids triacylglycerols (TAGs) from lipid particles by hydrolysis of TAGs, releasing and supplying specific fatty acids to the appropriate metabolic pathways.
Subcellular Localization:
Lipid droplet. Note=Partially retained in the endoplasmic reticulum in cells lacking triacylglycerols.
Sequence:
MTALFNFWRIMYANISSIWLLVVSFFEWLFSATSISQQRGSGPRKGKVVMNKDCRSWEDWKVLATTIDKASGRWKWRFTPASDKYDYLLIDRCTVSLKRYRQRKSVYPMLMFLRSSLLRNFGNIGNSSLYTENYSGTKILIEEYVREVNNCLEFLYHTKRLSYDVKCDFFSAARISFGTTCLYFNGGTAFGLYHFGVAKTLWKRNLLPQILAGCASGALIASLLSVYRDEELNGLFDTFPSELWKICQQTSDYSLSKVVEYGNMLDISMIASFVRQRLGTITFQEAFERTGRIVNIVAPPSAVSGSPQVLNYFTAPNVLIWSAVCSSNSWAAIYRSSPLLAKLPDGSTEVCTPKNFIWPYAGLPNTGRSNPYARISEIFNVNHFVITQSRPSLFPTFYDELHHHRVSGYSLKMIRLVGLEMAYRFRQLDILGLLPPRLRRFFVDDYVPSAYITLTPTFSFSDIKHAFTKPSLSDIQYWILVGERATWQAIPLLQVRCKTEISLRHLSKNLTNSYVEPLSVNNLASPFVTNLEENQEKMLKIFKVK
The following text describes a protein:
Function:
Has weak lytic activity toward S.aureus cells.
Sequence:
MKKLAFAITATSGAAAFLTHHDAQASTQHTVQSGESLWSIAQKYNTSVESIKQNNQLDNNLVFPGQVISVGGSDAQNTSNTSPQAGSASSHTVQAGESLNIIASRYGVSVDQLMAANNLRGYLIMPNQTLQIPNGGSGGTTPTATTGSNGNASSFNHQNLYTAGQCTWYVFDRRAQAGSPISTYWSDAKYWAGNAANDGYQVNNTPSVGSIMQSTPGPYGHVAYVERVNGDGSILISEMNYTYGPYNMNYRTIPASEVSSYAFIH
The following text describes a protein:
Function:
Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.
Miscellaneous:
MISCELLANEOUS: Present with 1890 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MFLEIPRWLLALIILYLSIPLVVYYVIPYLFYGNKSTKKRIIIFVLGDVGHSPRICYHAISFSKLGWQVELCGYVEDTLPKIISSDPNITVHHMSNLKRKGGGTSVIFMVKKVLFQVLSIFKLLWELRGSDYILVQNPPSIPILPIAVLYKLTGCKLIIDWHNLAYSILQLKFKGNFYHPLVLISYMVEMIFSKFADYNLTVTEAMRKYLIQSFHLNPKRCAVLYDRPASQFQPLAGDISRQKALTTKAFIKNYIRDDFDTEKGDKIIVTSTSFTPDEDIGILLGALKIYENSYVKFDSSLPKILCFITGKGPLKEKYMKQVEEYDWKRCQIEFVWLSAEDYPKLLQLCDYGVSLHTSSSGLDLPMKILDMFGSGLPVIAMNYPVLDELVQHNVNGLKFVDRRELHESLIFAMKDADLYQKLKKNVTQEAENRWQSNWERTMRDLKLIH
The following text describes a protein:
Function:
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTWAYAAGVPLASDRYGLLAFGLYGAFLSAHLVAQSLFAYLEHRRVAAAARRAAARGPLDAAAARSVALTISAYQEDPAYLRQCLASARALQYPRARLRVLMVVDGNRPEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAAGAGAYREVEAEDPGRLAVEALVRTHRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDTRLDPMALLELVQVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSRCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVLRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCPRMVLLSLYAPLYMCGLLPAKFLALATMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSLVHEARADWSGPSRAAEAHHLAAGAGAYVGYWVLMLTLYWVGVRRLCRRRSGGYRVQV
The following text describes a protein:
Function:
Seems to be required for the assembly of the CotSA protein in spores.
Subcellular Localization:
Spore coat.
Sequence:
MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHGPKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVTGKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGNMQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFTLARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVYPLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFLDKLPELYKKIKAYREAN
The following text describes a protein:
Function:
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein.
Sequence:
MERLHLLKDSFFGLETVQQQLIIGSVVAATGILAFFARRSSEVKTIPLGDGWWGTGQKPASEDEAVHPFTIQASDREIQDLHDRIDRTRFAEPLEHSGFQYGFNSTYLRRVVSYWRNEFDWKKQVAVLNTYPHFKTKIEGLDVHFLRVRPSHASGQRVLPLMLVHGWPGSFYEFYGILPLLTKNQDGVAFEVIIPSIPGYGFSEASHKQGLDSLAVARIFLKLMERLGFSQFYVQGGDWGSLITTNMAQMKPECVKGLHLNMCMSTRGFKIMLSLMIGPYLPFLVGLTREDVRRLFPFFKKNVWEILKESGYMHIQATKPDTAGCGVNDSPVGLAAYILEKFSTWTDYKNRDLADGGLERKYSLDDLLTNVMIYWTTGSIVSSMRFYKENFKSDPNSRIDGLTGIFVPTGVAAFPNELMHCPKSWAQIRYRNIQSYTLMPSGGHFAAFEEPQLLAKDIIQFVKKVEKL
The following text describes a protein:
Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
Subcellular Localization:
Nucleus.
Sequence:
MQNKILVVCKHWLRGLCKKSDHSKFLHQYDITKMPECYFYSKFGECSNKECLFLHADPAFKIRDCPWYDQGFCKYSLLCKFRHNRRLLCTSYLVGFCPEGHDYKFTHPKITLLLHNTSHSKNVSQLQRPTQLASIMLFGHLPIQAKPPSPAYTSLLGRDTTIASYIQELQHKLC
The following text describes a protein:
Function:
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Sequence:
MAKIEIYTTARCPYCVRAKALLDRKGLDYMEIRIDEAPEKRDEMLSRSEGRRTVPQIFINGRGIGGFDELWELEQSKKLDELLKT
The following text describes a protein:
Function:
Synthesizes selenophosphate from selenide and ATP.
Sequence:
MTEGIKLTSLVKAAGUAAKLGPAGLEQALSDMVREDDPNLLVGPETADDAGVYRIGEGLALVETVDIITPLVDDPYTFGRIAAANALSDVFAMGGRPVTAMNLVFFPACALPGSVLSAILAGGHDALREAGACLVGGHTVEDDELKYGLAVTGLISPSRVVRNATARAGDRLVLTKPLGTGIVSTAIKADMAPAALTAEAVRWMTMLNAEAAGLMLECGASACTDVTGFGLVGHACEVARGAGVTLRLHLEQVPVLDGVMGLVADGLVPAGCYRNRDHYAPFVGAPRSDDDRLLPLFDPQTSGGLLLSLSPSSAGRFLAAAGDRGLFALEVGEVLPAGECAVDIV
The following text describes a protein:
Function:
Involved in induction of programmed cell death in response to reactive oxygen species (ROS). May be involved in sterol transfer between intracellular membranes.
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Localizes to puncta in the cell periphery representing cortical endoplasmic reticulum (cER)-plasma membrane (PM) membrane contact sites.
Domain:
The VASt domains bind sterols.
Sequence:
MRDEATRKKRSFSDGHFFKKLKLMSRKKQPVMERSKTTRTRKESTNSAAKSSLSLRRANNGRKTIAKRRVLTDIGSTNEGVAGNSGSNSPAQYSHTPHFSDSIPPLPLELPDIVSIRSSRSHISNKSNKNKHGIDLTFIPRRSLQNSKAGLKKPNTSPQGYFNIPVTIDRASEKVKHTDTKNTFNSSSSENERPVLSILQKDDSQSSSHPAIDSMSAPNNINNNNDIENSSNSLFDTILSIAHSAISHVPKISALNTEIQREFSHSGESHTGSTRHPYFHIHHAQQQHPLSQQQGPLPVSENANQNPNDTVLIHSPSANTAHRSSSFLRHLDYLLSPTSGPASDKHTQVEEGDDEEELSPLSKAFLSPSTQLVPTNTSTTPLSGSLTPNNRNVNANSNSETENDNDRDDRSNVGKVKFQPLKVHEPAISTFGKGNLTLEAVAGSSDIDNTTIDLDENNTNNNPNASSTNLSHISKSNVNNNLGPKELNTSYRNSTYIDMARFENSQSNLSSHRARSKTLPANKALENAVGDEGNSKRNSRYSSYSNDMAFDDADERKFRSMSKKFLNRRSFSPSNLGNKVIPGINLRNSFNKNRNSSSDFFSTNQGQQMPRTSTAGSGNIHAIMGLDSGNDDFKLEGIEYASEKKNSEFHTLFKDCDINPNEKLIVDHSCALSRDILLQGRMYISDAHIGFFSNILGWVSTVFIPFKEIVQIEKKTTAGIFPNGIVIDTLHTKYIFASFMSRDATFDLITDVWNQIILGKKYRNGFGNNDDGTISDSSSAFFDDSDDNDDDGDLDDDDPDINSTDMTSSDDIDADVFNESNDLGKNQKSTNYLLGPNKHSPTTADFKPSNNDHLVIEANINAPLGKVVNLLYGEDVSYYERILKAQKNFEISPIPNNFLTKKIRDYAYTKPLSGSIGPSKTKCLITDTLEHYDLEDYVKVLSITKNPDVPSGNIFSVKTVFLFSWDKNNSTKLTVYNSVDWTGKSWIKSMIEKGTFDGVADTTKIMISEIKKILSDEDSNINSKHQASNNESEEEIINLPTIGPPVHDPTEPDFQKGKDDTVIDEKINIPVPLGTVFSLLYGDDTSYIKKIIENQNNFNVCDIPKFVNNAREITYTKKLNNSFGPKQTKCIVTETIEHMDLNSFFMVKQIVRSPDVPYGSSFSVHTRFFYSWGDHNTTNMKVVTNVVWTGKSMLKGTIEKGSIDGQRSSTKQLVDDLKKIISNASSTKKKSRRRGKTVNKRKSSPSTIKNEKNEENFEDTSTKNSFFSAFSMLQQVNITSVQGIMTIISFFICLIFFFRLLFHSKNTSNIQIITPGTILINGNEYNYVPNFKTLYHVYEDNIIKDARRKDSNKNNIVTDTEGLIWDWLIDRGNGTVQNSVLSNHIKESNNKKVKLVNGVSDHKIQQLVESIKITELQLQEMKELLAQTDNTSATNQLL
The following text describes a protein:
Function:
Involved in cyclic AMP (cAMP) pathway, possibly by participating in the assembly or the conformational activation of specific multiprotein complexes.
Sequence:
MGVDLSDINDSLFKLSDKLSNDLAKQRNLCIVKEPSFSIEEHIKCFTTCINTYKPFSCLKHANWALLLAKKKSDTGLIGYCQSLRGLAYYLLEQYQSSAICFGFALKHLKKEDLTKWQVQLDSMLTIVHEQQNQDTSSLIPDECPNIPELEAAKIEGDEEFLNMSLKAPEGQIEKNEEKLSNRIRYDWSQTSFSLNIDIYAKKVKDEDVSLLMEKNTLKIEIKLEDGSIFSLVLDPLYEEIVPEKSSFKLFSSKVEITLIKKVSEIKWEALVKSPANNSVNVYAKDSNHSSASGNTKNKAKDWDSLAKLADLEEDEPTGEAALANLFQNLYKNADDDTRRAMMKSYTESNGTALSTNWKDVKSKTFETKPPQGMEPKKF
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MQQIGHSILSKWYSSNYFYRALFQYEVKEEGYIMGKLIESKEDILDVVIHTIRFTYREGFQAYQCQNSTLTTDSGWGCVIRVGQMMMAELLKRHLKCFYNVNLFQFPPLMQEVLQLFKDDDEMESLKVQGKPSKYGFSIQKIMRIAYEEWGKKPGEWYSPNQIVQAIYKILSDNNIIYSCGLSLLPFYESQIDLKVILQEMCVMENCICEQRVFFIEKFLQDLVRLEINKEEVIQVIHGNDSISDVYYEDLSQQNKQEIGMLLKKYVCQKCFVPIRAVAICLLSRIGCDEPNPDYIQAIRQFMKKKYFAGLLGGRPREANFIVGFVDDKFVVLDPHLVQQANMNPEEYVKSCFPGEALFMSDKEIDCSLGLVFYLKNEEDLIELIYDIQAHQQINFFSFATIQNWTYSKIQKEVELEKIKEMQNFLNEFLVQQQQQILNLDVSANLEGYEIGSSQQTLVNDIEYSYEQI
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MLRRKPTRLELKLDDTEEFESVKKELESRKKQRDEVDVVGVATSSEMSGAAGGTADGKTREQMIHERIGYKPHPKPNTLPSLFGNLQF
The following text describes a protein:
Function:
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine. Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate. Also has adenosine deaminase activity.
Sequence:
MPDIFQQEARGWLRCGAPPFAGAVAGLTTKHGGESKGPFASLNMGLHVGDDRTDVVNNRRRLAEWLAFPLERWVCCEQVHGADIQKVTKSDRGNGAQDFATAVPGVDGLYTDEAGVLLALCFADCVPIYFVAPSAGLVGLAHAGWRGTAGGIAGHMVWLWQTREHIAPSDIYVAIGPAIGPCCYTVDDRVVDSLRPTLPPESPLPWRETSPGQYALDLKEANRLQLLAAGVPNSHIYVSERCTSCEEALFFSHRRDRGTTGRMLAFIGRREEWT
The following text describes a protein:
Function:
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein. Cell projection, cilium membrane; Peripheral membrane protein. Note=Appears to be mostly membrane-bound, probably via interaction with syntaxins, but a significant portion is cytoplasmic. Localizes to the ciliary pocket from where the cilium protrudes.
Sequence:
MSGYPKSYNPFDDDVEEEDTRPAPWKDVRDLPDGPDAPIDRQQYLRQEVLRRAEATAASTSRSLSLMYESEKIGVASSEELVRQRGVLEHTEKMVDKMDQDLKMSQKHINSIKSVFGGFINYFKSKPVEPPPEQNGSIVSQPNSRLKEAINTSKDQENKYQASHPNLRRLQDAELDSVPKEPSSTVNTEVYPKNSTLRTYHQKIDSNLDELSVGLGHLKDIALGMQTEIEEQDDILDRLTTKVDKLDVNIKSTEKKVRQL
The following text describes a protein:
Function:
Subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins in the endoplasmic reticulum (ER). Specifically required for the cleavage of the final glucose. The subunit beta retains the catalytic subunit alpha in the ER.
Subcellular Localization:
Endoplasmic reticulum.
Domain:
The N-terminal conserved region (G2B region) is required for the interaction with gls2 and its translocation to the endoplasmic reticulum, whereas the C-terminal conserved region (MRH region) is involved in the recognition of N-glycans bearing from 5 to 9 mannose units.
Sequence:
MKFSQWYTLTAPLLISSLYTVNAANDLRGVASDKSDLYKPDAKGNWKCLGSDKLISFNQVNDDYCDCPDGSDEPGTSACHNGKFFCKNTGYISSYIPSNRVDDTVCDCCDGSDESLIKCPNTCAQKAREYLATLEEHNRLVKNGLKIREQWALESAKKTDEVKARYKEISDSLVAVSAEKTQLSEKVEKMKRSTDLGAEAVLPLDFQDLRVALLSLVDERNEMQERLDILTNLLDELTLLYETDKFDETMKEAILSFEDLKEQEIRRKVSSDDVHNYLESCNNHLSMLTGPSEDITFSSLIKDIKKILNSLVWNIKLSLINFGILSPSASSTPLTDSESYRRFEAAQRDLDAAEENEKSLEKEHTKLMHELEYHHGWDLYRAIKGMETKREIGGYTYKVVFYENVFQDSILLGNFASQEGNVLKYENGQSCWNGPHRSAIVTVECGVENEIVSVLEAQKCEYLIKMKSPAACSPDQLKQSLLNTQNSANENAVNGMEDKESSVDEL
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Sequence:
MRGTRARDIVDIRARLHTSRAAFTWTSRSVSATAATACLRHHTDSNWRLYPIRQAIQSPAYKLQSRHLSEANAILASHHGPQKGERVVVALSGGVDSSVTAALLAQADFDLEAVFMRNWNELDESGRMQPGSGGASGCTWQRDWQDVQSVCRHLGNIPVKMIDLSKEYWTQVFEPALQDWQQGTTPNPDVSCNKEIKFGALMDRLIRTGDHGGSKSWLATGHYAHVAWQQQGDRTRPMLMRAKDRSKDQTYYLSSVGEDKLAHAHFPLAHLLKTQVRELAKKFQLPTAERRESMGICFIGTRGSNGGAVSNTQGFSTFLNGYIPSAPGDMVDESGRVVSKHCGLHTLTVGQGARIRGATSKYYVAKKDIPNNKIVVVQGKDHPMLLCTRLYVRDIEWIWREPPPELKYDGVGRVTLLAQVRHRQVESECVVSRFKQGKNGYVVQFTEPVLAVAPGQVLGLWRGNWCLGSAVIESVDTVYDDLAQ
The following text describes a protein:
Function:
Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.
Subcellular Localization:
Apical cell membrane; Lipid-anchor, GPI-anchor. Membrane; Lipid-anchor, GPI-anchor.
Sequence:
MGRLLATISQTEDLCSLFQHTQQLLTASAGPRRAQASLVDCVMWISWWLWPLVAICAGDRFRDEAERIMRGTPVIDGHNDLPWQLLTRFNNQLQVEAANLTSLTHTHTNIPKLKAGFVGGQFWSAYTPCDTQNKDAVKRTLEQIDVIHRMCQMYPETFVCVTNSTGIRQAFQEGKIASLVGVEGGHSIDSSLGVLRTLYHLGMRYMTLTHSCNTPWADNWLVDTGEDKGESQGLSPFGQRVVKEMNRLGVIIDLAHVSVSTMKDALSLSKAPVLFSHSSAYSLCQHRRNVPDDVLQLVNQTGSLVMVNFYNDYVSCKKEATLSQVADHLDHIKKVAGAGAVGFGGDFDGVSRLPLGLEDVSKYPDLVAELLRRQWTEAEVRGVLANNLLRVFEAVERVSDHTQTPEEEPISLDKLQDSCRTNYGYSEAPSFHHQPRVLLASLTTVLLGLCLL