lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MRESQKKQQQTLILLAATTLLNVTAVALAQPNKVCTTPCGCKSRVIKRLEVYTTQFERALGQHQANLLDFSKLILAAVAADNQLKRKAAAALAPAAAILARCTDQLNAAAPPLTAAAYQAGYTAATYAAQHALTTMAGTLKIEPTGGKTLKAETITTKTLGSIPPAMCPTEDQTETGVKITTESEKDEPKLATIKLHSNAQAKCTATGANSCHDNALADSGNLEIQLTYAMGQKKTPWTWNSNTNADFQTTHSAEINLLRGNESDLDSKLTTLRTAHALDSCRKAIAEYSALSSDPNWALFNAKALLDNFESEKPSDISSDRLEQATNKAYGPDGTNYKNNVWHKIEQTQVPTVQHEQLKLQPIKSLSSTDEIGAALARVFINQQKKETQTHQKQGQKDDDTKENECSNKNGDKCKGDCVLDGDICKPKKKGEDENKEKDGKTASTCAGKDEKTCGTTQGCSWENNACKDFSILLTKQFALSMVSAAFVAFLF
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MNPDLLKVFLIEVPKNLGFDDFKGLQHYITKVLFYSATDEGKYLKTLFPRISPEDFDPSTVYNIPSSTEVLNPFYEVSGSKYSHPPDEACAKPFQPGDPVYRCDECGFDSTCVLCASCFNKEDHLNHNVTVYTSSGTSGGICDCGDPEAFIRPLNCKCQTNRDELEEDVSGMMDALQKTIQIAIDYVLDVSNFTIMTLPLIHTELNEQYPKLDIRELSDYLSLPEESYSGASDVNSTNRWALILWNDEFHNLTEAVTAIKAGTGVDDRNAYKIAEKIDIKGFCVLKEDDNPQKLIQAKRLVESNGLVATIVSARDLLREKIASSIIDWIIAISNSSNSQVRKAAQSYFAELLLEPHFRFSKVIPSSVFQETLASKSTQDQFLAYFKNGLPYNGELISFNYHQLRATANQISLYEPISSLLDSTRSTERLKGSRLQYLLAFQIRFPKLTRQKLGTLLVPPLVTTSTLKREFANQFVELFPALLTIMGLTDREEDLNLMSDITSQLFTCPQTVRSILDKGGVKNLLGPLAKLIEEHSTTRDTNTGYRLYCEIGSDSQQKRAIKKAIVHGIYNLSYFSNHGLSGDSITKFLQPDHFSLLVLMLRYFQSYWPVTRKYGEHVERDDFDLSVHVEISLPILKCVKNLGVDMPRNKEIPTVVAQLIELLSKKKNEFIEPGVIKFQVSKEPVAIVNPLNSLLSYFLQFQNIDNFKHLLQQNQSELVNFTDISLRSIVLGSQVKAGFWIRNGSSVSRQATAYFDSLMTEYAFMRDFHLNQIAILFEDQEKVLMNFLERWELRSWFKNEVDFDKTIYEERFFSIVERFIAFAYNLFVDRSMFINETPEDATLRKLNHAIGYALCEEAMAFSELHQYIDTNIASSSKFEDVLYEVADYQPPSALTDSGLYRLKESTYEKLDPLNILVDPGKFQIISEMVIKNSSKQKKRKSENLIVTPVIEKAGNDFVDENIGNFAKSLPFVKLIYKLMQVSIDTSDETYLPHLLHLVHAIMLDDEMIHGKEYLNKHFVDIPITDLLLTISESTMSKYVCQKADYLVEQLVGKDKRIIASLVDCFGEDYIQRYKKRKNSLFESDAERKKRKAEKRKNNIFKKFSKQREKFLNQNQEFQSDIPQDSNIPMEGEDSRKLRTCVACGELESFEKPLAIMAASTKAPVFWKVPVQTGEVVSNAFKTWDKNILLDYKDTEYGVGYDPVSRSSLDSNRFESYVLSTCGHSIHHSCLNRRIIGSAQYSCPLCHNLHDMIILTLLGNRDSNIPAEVFNGSPNHLKYNQIVESADPNRKLGYLLDVFFKPEYFDAPSKTVTMASLGEAPLNHFKNQKYLPPGINSSYGIIFNRLMNWTVVLADTIRMNEISTRLNGVDGYSDFLSQIPGSAKTLLICMFQMRVLNAASSLLPLSADESNTFQSEFKSFWNSDLILDGVFNEVLVLFFQTDESLATLTRVGMSKLIAIVIKSLTARHEKDNSYLKCIDVDNGNQVSDVSLERFHRLFTGVMHGNDCEIPEVDKSISLIIYCAIERILGIFLRQVIIFKDILTCKQTGENNYESIPELLDLQKKIKLQDRLTDTKPLTDALGVPSFDELIETLLESSDALEGNVFDIIWLAKIPKYHDKGILTLEYPGIVHLVNLPVDYNSCVLNASQIATHDNSKCLICGQWTNASRNVAHMLNCSSQIGILFISKSNMLRICVYIGTSPITIELPAPYLTKHGEIKVIDKRGRATLSGLRFAYLNKLWVTQGLYGFVTRNLFGSGFALEDDVTFNFERNIPDLSEDDDGIGLFEWVD
The following text describes a protein:
Function:
Transcription regulator that negatively modulates gibberellin-mediated developmental processes. May act as transcriptional repressor of giberellin controlled genes. Binds DNA without sequence preference.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing ET display dwarfism due to short internodes, late flowering, reduced germination rate, increased anthocyanin content and reduced xylem lignification.
Subcellular Localization:
Nucleus.
Domain:
Contains a bacterial GIY-YIG-like domain.
Sequence:
MFCLNTFKSRWPREFQNLKKKKKKTCVKLSIPIRSVTGDAASLTVVVTMYKRDDYVRNKPGGVFSRWQGFARSMLLPKPFSETAELRRTVADYSLISRGLAPKILREAKGNREDLRVGKDFVGSRYRVQESIQGLGVAVNIHDADDISHGQTESIRTRLRSYGRPVPLLKKLGDNASQTITQKKTGGRSKDKKHGFEEERDVSRVEAEENNTNSVHASVLRLSRSRPQPVLERHDDIVDGSDSASVCGVLQEDGTTCLTAPVTGRKRCTEHKGQRITCAPPVKNPPCEEETEEICGVILPEMVRCRSKPVSGRKRCEDHKGMRVNAFFFLLNPTERDKILKEDKSKPKTRTSSTNQEEPGESLICEATTKNGLPCTRSAPNGSKRCWQHKDETVDQKSSENVQTSTTVCGVKLHNGSVCEKTPVKGRKRCQEHKGMRITS
The following text describes a protein:
Function:
Plays a role in the inhibition of host innate immunity by inhibiting the interaction between host IKBKE and MAVS. In turn, this inhibition prevents the production of host interferon beta. Additionally, may also interfere with host antiviral response within the nucleus.
Subcellular Localization:
Host nucleus. Host nucleus, host nucleolus. Host cytoplasm. Note=Mainly localized in the host nucleus.
Sequence:
MDDSMDLDLDCVIAQPSSTIVMMPLSPISTRKRRRHPMNKRRYAKRRFTPVEPNDIIMCDKPTHCIRLVFDQSLRWVHFDGIKNILTDYDVIFNPDLHVTVALVCAGNGVTFSDLTPLTFILADMLLEFNGIFTLGQTLVIGAREYHWLPQELKTNVGKAIPQAKEWLVDHGYNVYHTGLPTHMSLAKLHSLDFVQQSYVGSKFFIKHSHTTEYAMPVCLQVIAIDGEKVDGRSKPLFQYPIHNHYRHYRACFPGR
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MKDNIELTIFTPEKNIKIGEIKEVITEGLDGDLAILPNHVNMITYLKPTITKYIDLNGNKNNIFTSSGVLKVEDNKVYIICDASEKPEDIDIKRAENARKRAEERLRNKKEIDVKRAELALFRSIARIKIKEL
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MAQESAAGDLMYVDDFFLSMLFDVEEENEILPLSDEKYAEELQFQEVLMGSMITSQHANKGASSSSSFSSPLIQASSSTQNPEPVEETKEAGESSSCFCEICAERKDSEEMFKNHSCVHSFCSDCISKHVATKIQESITVVSCPELGCETVLTIDACRRVLPKEVQERWDSALCETQVPAFQTFYCPFKDCSAMLLNDNEGGEVIRESECPSCHRLFCAQCYVAWHPGVECEEYQRLNEDERGRDDLMVRELARERRWMRCPRCKYYVEKTEGCLHITCRCAFQFCYGCGVKWTGDHGGCQRN
The following text describes a protein:
Function:
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
Subcellular Localization:
Cytoplasm.
Domain:
The PRC barrel domain binds ribosomal protein uS19.
Sequence:
MTKWFNVGKIVNTHGVRGEIRVISRTDFPEERYKVGNTLYISNEKGTDYLPVKVTSHRQHKTFDLLTFEGYNNVDEVEKFKGSLIKVPEEQLGELAEGEYYYHEIIGCSVVTEEGEALGTIKEILSPGANDVWVIKRPKGQDLLIPYIDDVVLQVNIENKLVTIHVMEGLL
The following text describes a protein:
Function:
Catalyzes the dehydration of D-xylonic acid to form 2-dehydro-3-deoxy-D-pentonate.
Sequence:
MSVRNIFADESHDIYTVRTHADGPDGELPLTAEMLINRPSGDLFGMTMNAGMGWSPDELDRDGILLLSTLGGLRGADGKPVALALHQGHYELDIQMKAAAEVIKANHALPYAVYVSDPCDGRTQGTTGMFDSLPYRNDASMVMRRLIRSLPDAKAVIGVASCDKGLPATMMALAAQHNIATVLVPGGATLPAKDGEDNGKVQTIGARFANGELSLQDARRAGCKACASSGGGCQFLGTAGTSQVVAEGLGLAIPHSALAPSGEPVWREIARASARAALNLSQKGITTREILTDKAIENAMTVHAAFGGSTNLLLHIPAIAHQAGCHIPTVDDWIRINKRVPRLVSVLPNGPVYHPTVNAFMAGGVPEVMLHLRSLGLLHEDVMTVTGSTLKENLDWWEHSERRQRFKQLLLDQEQINADEVIMSPQQAKARGLTSTITFPVGNIAPEGSVIKSTAIDPSMIDEQGIYYHKGVAKVYLSEKSAIYDIKHDKIKAGDILVIIGVGPSGTGMEETYQVTSALKHLSYGKHVSLITDARFSGVSTGACIGHVGPEALAGGPIGKLRTGDLIEIKIDCRELHGEVNFLGTRSDEQLPSQEEATAILNARPSHQDLLPDPELPDDTRLWAMLQAVSGGTWTGCIYDVNKIGAALRDFMNKN
The following text describes a protein:
Function:
Transcription activator involved in the spatiotemporal regulation of flavonoid biosynthesis specifically in the corms of Montbretia. Activates the promoters of enzymes involved in the biosynthesis of the flavonol kaempferol and the flavonol-glycoside kaempferol-rhamnoside.
Subcellular Localization:
Nucleus.
Sequence:
MGRKPSCSKEGMNRGAWTAMEDGILVSYIQKHGEGKWGSLPRRAGLKRCGKSCRLRWLNYLRPGIKRGNISEDEEELIIRLHRLLGNRWSLIAGRLPGRTDNEIKNYWNTTLGKKVLRNSGRSKEDNQAAPEQEASPVAVRSKALRCTARLPVVQVQPAAPASHGCPSETAVGDDGVREEQAADEAAPAPAVEVQQKQLDFLPEDELSIDLDFDMGELGFLSPWRGEVGGGVGPGDRFDGDEVDDLEALLLGPGGDGNLHEFAWF
The following text describes a protein:
Function:
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Subcellular Localization:
Cytoplasm.
Sequence:
MNTLYLGSNSPRRMEILTQLGYRVIQLPAGIDESVKAGETPFAYVQRMAEEKNRTALTLFCETNGTMPDFPLITADTCVVSDGIILGKPRSQAEAIEFLNRLSGKQHTVLTAVCIHYRGKTSSRVQTNRVVFKPLSSEEISAYVQSGEPMDKAGAYAVQGIGGIFIQSIEGSFSGIMGLPVYETVSMLQDLGYRSPLSALKP
The following text describes a protein:
Function:
Binds together with bS18 to 16S ribosomal RNA.
Sequence:
MRKYEIMYIINPTVLEEGREELVNQVNALLTSNGATIAKTEKWGERKLAYPIDKKKSGFYVLTTFEIDGTKLAEVESKLNIMESVMRYIVVKQD
The following text describes a protein:
Function:
Essential for biosynthesis of the polyamines spermidine and spermine. Essential for polyamine homeostasis, and normal plant embryogenesis, growth and development.
Sequence:
MAVSGFEGFEKRLELRFFDDDKPITKNPMGLRLIDFESLDQVLNEVQCTVVSAVANRSFDAYVLSESSLFVYPTKIIIKTCGTTQLLKSIRPLIHLARNLGLTLRACRYSRGSFIFPKAQPFPYTSFKDEVIVVEESLPKSLCYRKASVMTPSNNPSRAWHVFTASADVESDEHVVVVEVCMTELDRVNARSFFKRKGDEKNNSDSAGKEMTRLSGIDNINANAYICDFAFDPCGYSMNGVDGDRYSTIHVTPEDGFSYASFECGLSLYDNGHEDISEVLSRAIDVFRPSDVSIATTYGGEDYNHEVTKRVERVLAKKLDLKCRSRLMDEFPGSGTVVYQSFTPRRK
The following text describes a protein:
Function:
Involved in organ growth by promoting cell elongation processes.
Subcellular Localization:
Vacuole.
Sequence:
MASKSLFLVALLVGSFAFTSFASVANRKLKSGLEDQKTFFHHPGGGLGGGGGIGGGSGLGGGGGFGGGGGLGGGAGGGGGLGGGAGGGAGGGFGGGAGSGGGLGGGGGAGGGFGGGAGGGSGGGFGGGAGAGGGLGGGGGAGGGGGFGGGGGSGIGGGFGGGAGAGGGFGGGHH
The following text describes a protein:
Function:
Possesses E3 ubiquitin-protein ligase activity in vitro. Mediates mainly 'Lys-48'-linked polyubiquitination. Promotes abscisic acid (ABA)-induced stomatal closure, reactive oxygen species (ROS) production and drought tolerance. Involved in the regulation of stomatal aperture.
Subcellular Localization:
Nucleus. Cytoplasm. Endoplasmic reticulum.
Sequence:
MDMGFHENEQNQEFANLMEIGSGHYGCSHYRRRCKIRAPCCDEIFDCRHCHNEAKDSLHIEQHHRHELPRHEVSKVICSLCETEQDVQQNCSNCGVCMGKYFCSKCKFFDDDLSKKQYHCDECGICRTGGEENFFHCKRCRCCYSKIMEDKHQCVEGAMHHNCPVCFEYLFDSTRDITVLRCGHTMHLECTKDMGLHNRYTCPVCSKSICDMSNLWKKLDEEVAAYPMPKMYENKMVWILCNDCGSNTNVRFHLIAHKCSSCGSYNTRQTQRGSDSHSCSSGMPQVVGSTG
The following text describes a protein:
Function:
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
Subcellular Localization:
[Transforming growth factor alpha]: Secreted, extracellular space; [Protransforming growth factor alpha]: Cell membrane; Single-pass type I membrane protein.
Sequence:
MVPSAGQFALFALGILLAVCQALENSTSALSADPPIAAAVVSHFNDCPDSHSQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
The following text describes a protein:
Function:
Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype. Plays a role in ciliogenesis by ubiquitinating OFD1.
Subcellular Localization:
Cytoplasm. Cell membrane. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Synapse. Postsynaptic density. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus (By similarity). Expressed in the postsynaptic density region of synapses (By similarity). Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane (By similarity).
Sequence:
MSQYTEKEPAAMDQESGKAVWPKPAGGYQTITGRRYGRRHAYVSFKPCMTRHERSLGRAGDDYEVLELDDVPKENSSGSSPLDQVDSSLPNEPIFEKSETEIPTCGSALNPTTESSQSFVAVHHSEEGRDTLGSSTNLHNHSEGEYTPGACNASGVQNGIALVHTDSYDPDGKHGEDNDRLQLSAEVVEGSRYQESSGNTLFELENREAEAYTGLSPPVPSFNCEVRDEFEGLDSVPLVKSSAGDTEFVHQNSQEIQRSSQDEMVSTKQQNNTSQERQTEHSPEDSACGPGRICSEQNTNDREKNHGSSPEQVVRPKVRKLISSSQVDQETGFNRHEAKQRSVQRWREALEVEESGSDDLLIKCEEYDGEHDCMFLDPPYSRVITQRETENNQVTPESGATAGRQEVDNPFWNGCGDYYQLYDKDEDSSECSDGEWSASLPHRFSGTEKDQSSSDESWETLPGKDENEPELQSDSSGPEEENQELSLQEGEQTSLEEGEIPWLQYNEVNESSSDEGNEPANEFAQPAFMLDGNNNLEDDSSVSEDLDVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDGLPETLVLEDHTAIGQEQCCPICCSEYIKDDIATELPCHHFFHKPCVSIWLQKSGTCPVCRRHFPPAVIEASAAPSSEPDPDAPPSNDSIAEAP
The following text describes a protein:
Function:
Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
Subcellular Localization:
Nucleus.
Sequence:
MVDVLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREPRRHRQKIEDQTKAFPDRFGDLRMRVTPSTPSPRGSLSTTSHFSSQAQTPIQGSSDLNPFSDPRQFDRSFPTLQSLTESRFPDPRMHYPGAMSAAFPYSATPSGTSLGGLSVAGMPASSRFHHTYLPPPYPGAPQSQSGPFQANPAPYHLFYGTSSGSYQFSMAAAGGGERSPTRMLTSCPTGASVSAGNLMNPSLGQADGVEADGSHSNSPTALSTPGRMDEAVWRPY
The following text describes a protein:
Function:
Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM6 is involved in assembly and stability of the TOM complex.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MDGMFAMPGAAAGAASPQQPKSRFQAFKESPLYTIALNGAFFVAGVAFIQSPLMDMLAPQL
The following text describes a protein:
Function:
Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.
Subcellular Localization:
Host nucleus.
Sequence:
MDSSEGCTDMDEPSPGFILNMTSDAKVRSVVEQIDRLSNITTSPPEMGWYDLEFDPLEDEGPFLPFSAYVITGTAGAGKSTSVSALHQNLNCLITGATVVAAQNLSRALKSYCPTIYHAFGFKSRHINICQRKVPKVTQSSIEQLQRYELARYWPTVTDIIREFMRKKQKGQYSSLSQSAFRLLCRMGGANLWTSNIIVIDEAGTLSSHILTAVVFFYWFYNSWLDTPLYRNGAVPCIVCVGSPTQTDAFQSVFNHTQQRNEISACDNVLTFLLGKREVADYIRLDENWALFINNKRCTDPQFGHLLKTLEYNLDISPELMDYIDRFVVPKSKILDPLEYAGWTRLFISHQEVKSFLATLHTCLSSNKDAVSTKLFTCPVVCEVFTEPFEEYKRAVGLTHMTPIEWVTKNLFRLSNYSQFADQDMAVVGTYITDASTQITFATKFVKNSYATLTGKTKKCICGFHGSYQRFKSILDGELFIESHSHDNPAYVYSFLSTLLYNAMYSFYAHGVKQGHEEFLRDLRELPVSQELISEMSSEDVLGQEGDTDAFYLTASLPPSPTHAALPTLVAYYSGAKELFCNRLALARRHFGDEFLHSDFSTFTVNIVVRDGVDFVSTSPGLHGLVAYASTIDTYIIQGYTFLPVRFGRPGGQRLSEDLRRKMPSIVVQDSSGFIACLENNVTKMTETLEGGDVFNICCAGDYGISSNLAMTIVKAQGVSLSRVAISFGNHRNIRASLVYVGVSRAIDARYLVMDSNPLKLMDRGDAQSPSSKYIIKALCNPKTTLIY
The following text describes a protein:
Function:
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MMDRDFVRAALAEACARHFFETFDGNLGNLRDLYHEDAWMTFVGEKYQGRPAISAKFESLGLQHSQHSITSVDSHPMREDGAMFVQVLGHWNFTEAGGHQQIRNFCEGFYLLPTPEGGYCIMNDIFRLVSPVPPENYYMITD
The following text describes a protein:
Function:
Probably a major component of the bacterial microcompartment (BMC) shell dedicated to ethanolamine degradation (Probable). Each homohexamer has a central pore with an opening of up to 8.6 Angstroms. A positively-charged funnel leads to the pore from each side of the hexamer; a phosphate or sulfate ion is found in the pore. The pore probably allows metabolite passage into and out of the BMC.
Subcellular Localization:
Bacterial microcompartment.
Sequence:
MEALGMIETRGLVALIEASDAMVKAARVKLVGVKQIGGGLCTAMVRGDVAACKAATDAGAAAAQRIGELVSVHVIPRPHGDLEEVFPIGLKGDSSNL
The following text describes a protein:
Function:
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein.
Sequence:
MIKFFLMVNKQGQTRLSKYYEHVDINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAALFIVVGVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDVSFFNTVFHGTWQAHSSPYQEPIDELHKICSALEPQQACFSPDSSFKGAASTTPIY
The following text describes a protein:
Function:
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. May be involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSKTVNFRATKNFYLQFVSVSSRDTSCIPCIHLFFDSKRYVFGSVGEGCQRAILSQQLRLSKIKDVFLMQGSSISSPDTYDSSSSSSTTSVSDMLQLDDRDKVIVSERNSMCSTVNYPTWWDSCGGFPGFLLSLNDISEPGETGEASPFVLHGPSEVHQFLSSMRHFTYHTNVNLTVQGYTSAEAPVFVDENICVTPVVVSLVKNSFKKRKHENINRGTNARPLKEDRANTSPHWYSHVSNDTSFVVENAMYNTPAPLEPDKPELFISYIVQSHPTPGKFDAAKAKSLGITKGLDCGRLARGEPVTLENGKTVYPKEVIGPSIPGSSFFIIHCPNELVIDLVIENHKWTNAPKPVCVIHSVTPEVYKNPRYQSWISSFPSEVSHLIASTEVNEVINYPRSAVAIATLNLLDSKVFPLGFNCYEVKNVQKNNRIAFAKPKLRFAFGKKTGIDDSEVGVSIEELKDKILKEKPDYKSFVEEAQKYVSDKPKAPSFAGSDIQICTLGTGSAMPSLYRNVSSTYVRIPVDKKCMEDSAISMKNILLDCGEGTLGRLSRQYGDNLKYEIASLRWIYISHMHADHHAGVIGVLKAWTKYSDGRSKLFITAPPQFEFWLLEYSRIDYLPLSNIVFISNSALRTDRKPSALESSRLSSLFKEFDLVSFRTVPAIHCPYSYCMEITNSSGWKIAYSGDTRPSEDFANIAKDSTLLIHEATLEDSMHEIAIKKQHSTYSEALEVAKKAGTKNVILTHFSQRYPKLPDIDISTEDLHIALAFDGMTLKISDISLFRYFGKPLAYLFNEENLKEESDPLKF
The following text describes a protein:
Function:
Required for the expression of the capsid proteins. Performs the splicing and internal polyadenylation of the viral capsid-encoding mRNA precursor, which allows its maturation and expression. Transactivates the viral promoter.
Subcellular Localization:
Host nucleus.
Sequence:
MSSESMKNKHRNSKRTPSPLQKERRRNWESHKSRSRSPIRRHGEKNLEYAHHSNQENRQSSYTALKTSDQATKTKEKTSGGNRTNPYTVFSQHRANHSDAPGWCGFYWHSTRLARDGTNCIFNEMKQEFQELQINGKITWDNARELLFSQKKKLDQKYRNMLYHFRHSPDCPRCDYWDNVYRRHLAHVSSQESEEVTDEEMLSAVESMDTNASN
The following text describes a protein:
Function:
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=May be also cytoplasmic.
Sequence:
MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENSAAVVAVETHTIHKIEEGIDASSIEANEDMEIAYPITCGESKAVLLWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSARAPVPGQQTSVVQTPTSADGNITQIAISEESMEEAGLEWNSALTAAVTMATEEGIKKESEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIHAPFQVTDAAVLNNVANTFGLMDTVKRVLDNRRKQVEHGEEQFLYTLADLERQLEEQKKQAQDPRLKSQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQGTSPVTVHTLPSGPQLFRYATVVSSAKSNSPDTVTIHPSSSLALLSSTSMQDGSTLGNMATMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEADDPEGKAVILETELRTEEKVVANMEERQHQVHNVEIVVLED
The following text describes a protein:
Function:
This protein is a beta-lactamase with a substrate specificity for penicillins.
Miscellaneous:
MISCELLANEOUS: The class A beta-lactamase family has a specific amino-acid numbering system, sometimes called Ambler or ABL numbering and often misspelt as Amber. A multiple sequence alignment was used to derive a consensus sequence and then the consensus was numbered taking into account insertions and deletions. This allows use of identical numbers, e.g. for active site residues, despite differences in protein length. UniProt always uses natural numbering of residues, hence there appear to be differences in numbering between this entry and some papers.
Subcellular Localization:
Secreted.
Sequence:
MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNMASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKKNSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLGGPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTTDKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVVAILSNRFTKDANYDNALIAEAAKVVLNDLK
The following text describes a protein:
Function:
Required for the induction the katG gene for catalase. Involved in the response to hydrogen peroxide.
Sequence:
MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTLRLGTVPTASTTASLVLSAFCSAHPLAKVQVCSRLAATELYRRLREFELDAVIVHPETQDSDDVDLVPLYEEQYVLLSPADMLPPGTSTLVWRDAAQLPLALLTADMRDRQVIDAAFADHAVSAIPQVETDSVASLFAQVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNALGPGSPVARALITCAQALALNEFFDTQLRGITRRR
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MTNERHDELACLGIFPLKNPKQLDGVVTPILQLRVKFLAPTDRWWEGLVINKDLSKEESEELWKFLQSFDPRSAKFVGRGTPEDHVISYLFEAGKYEFEVFFYQKDHSLKLMGLYDKTQKQLLRRDSSGDLTSTDKERDVSPVSHSEKPYWDRYDLDQPSNQDVEESRNLVQEPKHRSKKYDRLGLDELVMEQTASLWKICSRNGMSVDEFLRFIRMGLESNFQHSNQVIPTHF
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MVIPMSCMYTPLHPIEPSHLVLGATMEELCCANCGAFCSLHSQREMGKYWVCLSCKRRNSFQNNTAITEQHPALVYETVEFVLANPPTPVVAPPQPQPAPAFIFVVDTCIPSGEMASLRTSLLESLQYLPRNALVGLISFGATVSVWELGASSGVAIRKCYLLRGNTANPPDSLQSMFQVSENHPVRGRLLAPLCDVEGVLTSLIEELEEDGAAVPSSKRPLRATSTALEATTYLMEALAPPQMTAQQQYVLYGKHVKTATAPGGNVKMGKILLFTGGPCTRGPGAVVSTDKADMMRFHRDIIEGDTPYYEAAFNFYNALAPRLIAANTCLDVFAQSLDQVGVMEMRRCIDNTGGTLIIEDETTDIMFLESLKRYWQRCDLRAGTERASAAAPQGMSSSGVDGSYSSEDHRAHCGFAVRMEVNTSVGTLLRGALGPCNVDVEANKRGPTRLTSPLEVGAGGTTRWCVSYLDKGMTLSFLFDTATASNQQSGAASAYEKRFIQFVTRYTTPRGEQRVRVTSVVQPVAPPTAPPDYYTTAAAFDQTCAATIVARMAVSILEKHPGTWDAAKRWLDTLLVRFVRRYSTFTPGQPNTLRLGPCLSLFPSFMYNLRRSEYFMVLNISPDETTFKRHWLLRESVDNCVLMIQPTLDSYDLANPFATPMQLDSSSLRHDNIVLMDAYFNVHIMWGSIIYQWIEAAYHENPEYANFAELLEAAERDAQGILSNRYPYPRFSRTDADGSEARHVKTRVNPATNYHNSDMQYGAGPNGAVEQADVIYTDDASIMTFMNSLKKAVVTSDGKEEA
The following text describes a protein:
Function:
Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKKGNFMFKVLLMLIAGIFLSIDAFAQQITVKGIVKDTTGEPVIGANVVVKGTTTGTITDFDGNFQLSAKQGDIIVVSFIGYQPQELPVAAQMNVILKDDTEILDEVVVIGYGQVKKNDMTGSVMAIKPDELSKGITTNAQDMLSGKIAGVSVISNDGTPGGGAQIRIRGGSSLNASNDPLIVIDGLAIDNEGIKGMANGLSMVNPADIETLTVLKDASATAIYGSRASNGVIIITTKKGKNGQAPSVSYNGSVSFSKTQKRYDVLSGDEYRAYANQLWGDKLPADLGTANTDWQDQIFRTAVSTDHHVSINGGFKNLPYRVSLGYTDDNGIVKTSNFRRFTASVNLAPSFFEDHLKFNINAKFMNGKNRYADTGAAIGGALAIDPTRPVYSNEDPYQFTGGYWQNINSTTGFSNPDWKYTSNPNSPQNPLAALELKNDKANSNDFVGNVDVDYKFHFLPDLRLHASIGGEYAEGTQTTIVSPYSFGNNYYGWNGDVTQYKYNLSYNIYVQYIKSLGANDFDIMVGGEEQHFHRNGFEEGQGWDSYTQEPHDAKLREQTAYATRNTLVSYFGRLNYSLLNRYLFTFTMRWDGSSRFSKDNRWGTFPSLALGWKIKEENFLKDVNVLSDLKLRLGWGITGQQNIGDDFAYLPLYVVNNEYAQYPFGDTYYSTSRPKAFNENLKWEKTTTWNAGLDFGFLNGRITGGIDGYFRKTDDLLNSVKIPVGTNFNAQMTQNIGSLENYGMEFSINAKPIVTKDFTWDLSYNITWNHNEITKLTGGDDSDYYVEAGDKISRGNNTKVQAHKVGYAANSFYVYQQVYDENGKPIENMFVDRNGNGTIDSGDKYIYKKPAGDVLMGLTSKMQYKNFDFSFSLRASLNNYVYYDFLSNKANVSTSGLFSNNAYSNTSAEAVALGLSGQGDYMSDYFIHNASFLRCDNITLGYSFQNLWKTQTYKGVGGRVYATVQNPFIISKYKGLDPEVKSGIDANPYPRAMTFLLGLSLQF