lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide; Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation. Dendritic cells bridge innate and adaptive immunity by capturing exogenous antigens on MHC class-I molecules and presenting them to naive CD8(+) T-cells. Acts by forming a pore in antigen-containing compartments, promoting the release of antigens into the cytosol, enabling generation of MHCI:peptide complexes and T-cell priming.
Subcellular Localization:
Cytoplasmic vesicle, phagosome membrane; Multi-pass membrane protein.
Sequence:
MNSFMVTVFIWITVAYAEVEKALEEIYEDGFRKCQNALHLPVLEVLPGGGWDNLRNMDMGQVMDLTYTKCKTTEDGLYIIPDQVFTIPHKESNLELNSEILESWENYRSTTSFSINLNLDYRPKVNGKFSTEFQRIKTRQVRDHAVTTRVQVRNLFYTVKTDPNAELNLGFKKELMEICYRLEKNQTKMATYLAELLVLNYGTHIITSVDAGAALVQEDHIKSSFLKNNKGNRFAVTASAGFTFAKVLDFKIEAGFGYQNHLATGYLENRTDSRVQSIGGIPFYPGMTIETWQNGILNHLVAVDRAGLPLHFFIKPEKLPGFPHHLVEQLAKTVETAAKSYYNFNTYPGCTNINSPNFDFQANTDDGSCDGKVVNSPFGGVYQLCVQISGHGHEDMCQDFRQKNPLTGYFSCPSGYTPVHLLSQPHEKGYVEKECRNKCILKIFCNLECKDVFRVAKAEVKAYWCVASSQVPDNSGLLFGGVFTDKSINPTTNAHSCPTSYFPLKLFENLKVCVSLDHELGPKFSIPFGGFFSCTQGNPLYNSSTSGDLEKSFQQKCPGGFSQQLAVIIDGCQVSYCVKAGIFTKASLAPARLPPYTQLPMSEFSTDPVDVISSENAKSWVKDPYTLQWSLEEPSNTGGLSGGSTAGITVVVILALGVLIAMAIYGKRRFKKNESNEVPRPQTFLPFPRARATPDGV
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MENQMNPKLAQIFNERGMPLPTEDPPKNAIETDFNIKESGIIKKCESLEENSDLSNGDFARLRHHYLNQDIVNDKTKDIQKQLNEIENLLENGTESDIEQLYKQRHEWRKTIKENRGEAKICCVEDCINTVVPSSLYCANHILRDPNQKAYQKCEKCNRPYIAAIGCLSCKE
The following text describes a protein:
Function:
Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells; IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity); Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MNSLSTSTFSPVAFSLGLLLVMATAFPTPVPLGEDFKDGTTSKRPFTSPDKTEELIKYILGRISAMRKEMCEKYDKCENSKEALSENNLNLPKMTEKDGCFQSGFNQETCLMRITIGLLEFQIYLDYLQNYYEGDKGNTEAVQISTKALIQLLRQKVKQPEEVSTPNPITGSSLLNKLQTENQWMKNTKMILILRSLEDFLQFSLRAVRIM
The following text describes a protein:
Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAALLLRHVGRHCLRAHFSPQLCIRNAVPLGTTAKEEMERFWNKNISSNRPVSPHITIYSWSLPMAMSICHRGTGIALSADVGPRKRPEDSPAIPVWSGCPGSYCVVLYGAGSHVKNGAGDQFCRYLDEKAFSYCGEKDKYPCETSRPQTQEMMTRHNSLDLKTKGLTNHVGFKSL
The following text describes a protein:
Function:
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTPENDQADGPRMRRGRRLAVDVGDARIGVASCDPDGILATPVETVPGRDVPAAHRRLRQLVAEYEPIEVVVGLPRSLKGGEGPAAAKVRRFTQELAKGIAPVPVRLVDERMTTVTASQGLRASGVKSKKGRSVIDQAAAVIILQQALESERVSGRPPGEGVEVVI
The following text describes a protein:
Function:
Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Translocated to the plasma membrane in a Ras-dependent manner.
Sequence:
MESSDVELDLQRSVQAVLRELSTQAPALQSNQGMWRWSLHKKVERDPGKSPVLVRILLRELEKAESQDLRHVIIPLLHTVMYVLTKATGITEELYQRIYAFCTRLLTLPTPYCTVALDCAIRLKTEMAVPGTLYQRMVIAEQNLTNELYPYQERVFLFVDPELVSASVCSALLLEIEAAQAQQTPETCMRHVVSHALQAALGEACHAGALHRKLQASPRRTLEHYFHAVVAALEQMASEASPSREGHVERLEEIYCSLLGPAAGRCGGDLVQERPPSIPLPSPYITFHLWTGEEQLWKELVLFLRPRSQLRLSADLEVLDLQGLRPDRELARVSVLSTDSGIERDLPTGADELPAPGSPEMERAGLQRKGGIKKRAWPLDFLMPGSWDGPPGLHRRTGRPSGDGEMLPGVSRLHTARVLVLGDDRMLGRLAQAYHRLRKRETQKFCLTPRLSLQLYYIPVLAPEKPAASRQPELGELATFLGRVDPWYQSNVNTLCPAIHKLAEMPPSLDTSRTVDPFILDVITYYIRMGTQPIYFQIYTVKIFFSDLSQDPTEDIFLIELKVKIQDSKFPKDGFSPRRRGVAEGPGAELSLCYQKALLSHRPREVTVSLRATGLILKAIPASDTEVSGSSHCPLPAAPVTDHTCLNVNVTEVVKSSNLAGKSFSTVTNTFRTNNIQIQSRDQRLLTLSLDKDDQRTFRDVVRFEVAPCPEPCSGAQKSKAPWLNLHGQQEVEAIKAKPKPLLMPINTFSGIVQ
The following text describes a protein:
Function:
Has an essential role in the assembly of mitochondrial respiratory chain complex III. Is also required for STAT3 activation and plays a role in cell migration.
Subcellular Localization:
Endosome. Mitochondrion. Mitochondrion inner membrane.
Sequence:
MASVSTHGNQEKSPHLPPLSKQSLLFCPKSKLHIHRGEIAKIIRECQEESFWKRALPFSLISMLVTQGLVHQGYLAANPRFGSLPKVALAGLLGFGLGKASYIRVCQSKFHSFEDQLRGAGFGPEHNRHCLLTCEDCKTRRGLSEKAGSQPSAS
The following text describes a protein:
Function:
May catalyze the NADPH oxidation in the SfrAB NADPH-Fe(3+) oxidoreductase enzymatic complex. Probably involved in acetate metabolism and not in the reduction of Fe(3+) chelates. May serve as a major route for NADP regeneration.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein.
Sequence:
MAQVVFSSWGRTIVDNRKGGEAQDVSFRLPTTLDGERQIAAFMGWDGIILYDLKVDVPAMAAEYMKRVQTQYCCGKCTPGKKGTKVLADVLAAIIEGRATEADLDTIDDLADLLTNCKCTLCQSSTIPVLDAVKHFREDFLAYITGIRKPANVHRFIDKYTAPCMDRCPAHIDIPAYIEAIKEYRFDESLDIIRDNMPLPSVCGRVCPHPCETHCRRKNVDDSVNIMVLKRSASDYEWMHNAAPPMQPKPQKNKKVAIVGAGPAGLACAYYLALEGYPCTIYEALPEGYGGGMIAVGIPPYRQPRHLLQRDIDIISSMGVDIIYDTRIGKDISLEELKQKFDAVFLAPGAHRSKPMGVEGEDKGYKGFLKGGIDFLREAYMGRPTGMGKKVVVVGGGNTAIDCVRVALREGAEESTLLYRRSRKEMPADVWEVDGADEEGVRFEFQVLPTRVLVDENEQVTGVECVRMALGEPDASGRRRPEPVPGSEFVVECDTVIPAIGQDPDLSFIPDNLGIDITKWNTVVTKYVPLKDAAGKDLKDGMGNPLARVLITDLEGVFAGGDAEIGPLTVVACIGNAHRAARVIQRWLEEGKAYLTEDELMEDILTNMPVYDKNEKVPWLDSRERAHQAEVHGQERASKGNYQEVELGFVDTQAVEEAERCLRCYRVAMAAI
The following text describes a protein:
Function:
Sodium-phosphate symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLDILLQYAPNWTEHATWLVIVAFIFAFFVSYGMGANDSCNDWGPAVGAGTVTLPQAYFLSGILNVAGAVLLGYKVIETLRTGIIEFDIFDVYAQYNETTHQYDTVDHCGNATLIGGWKAPDILPGAEPLECAKYTSIDFMLTQTASLAGVAAFMILSSCFKIPVSATHAIVGASVATSFYIRGNVGIKWGEIINIVVSWFISPIIAGTIAATMYYIIKYSVLIRQDTFKWALRLCPIFMCFTLVVNLYACIYDGSKYLGLDRLDAIEAFLISVAIGVTGWAILTFPLRNWLPNRAHRLYDKETVKMQRRMEAGKATKSHKIKDMREPDVADNIKELPWYKYLWAYVPEDRLTKKVFNTLQIISSSMLSFTHGANDTGNTIAPLLAIWLCYESGYAFGNAETRDDTQMLLAYGSLAMIVGFVTLGHRTIKLLAHEMTVDMSPISGFCIEVGTAFTVLICVKFGIPISSTHCTVGAVVFVGMAKSTSEGVSFGTFRKICFFWLLCFPMSAIIGIGATIILQQFL
The following text describes a protein:
Function:
Mediates site-specific replication termination at the polar replication barrier RTS1, a barrier which ensures that replication of the mat1 locus in S.pombe occurs in the centromere-proximal direction.
Subcellular Localization:
Nucleus.
Domain:
DNA-binding domain 1 interacts with the repeated motifs encoded by the RTS1 element as well as the elements enhancer region. DNA-binding domain 2 has only a weak DNA binding activity.
Sequence:
MQGKNNLSCRPDTEDNEELFVDDQLLSPIGDSKNTSSFIYLGNPISFHEYNYDETMVSPENVKTAIAGSAKDHETCRGFKKTGTTSYKDFVFSRDYTNWTPTFWVLLSQLIDEFLKESELNFVAARDLLIKTKRLPKPFNNLLIQFQIQVPNVSRRTVYRHLKGYFNIPGYERFQYVKKASSGSWGANDIITLEKEIAMFKKKKNWSDEQFLQYVWSDNHRDEMKTLYNCLYELIDRDKKSIYNYLRRKYNPFKKKCKWTIEDEAELKKLVEKHGTSWSLIGKLSNRLPMHCRDHWRDYIQPGEINRSPWTIQEKEKLIKTVNQYLQSNPSSPIQWSLISKNMRNRHRHHCRWKYYTLISRDIHNSSPFKLGDSIWLIERMMDLNVAEERMIDWKCLSEYANHLWTADACKSHFERIKKTLFIDGLSTFSDTLIHLHKMLNSSPEETYISNLHDSYTAFSNADDLC
The following text describes a protein:
Function:
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Sequence:
MEFTFNVNHLFGESIAVVDRDLRPYRTHSHGSEDHQANLEKVIDQMGMASSKAQGLKHVITTARRLRFTDNKLYVVTDPMANGELGAVVGILKTGRKNLFVLDHHGNQTEMQPICVLDFYVHESCQRKGYGKKLFTHMLQAEGVKPHHLAIDRPSHKFQSFLMKHYKLRATIPQVNNFVIFEGFFNNQPETSYCRKRAMGKPPVPPNNRLVHQPSPTTPHRNATSSGVWGGGTSPSPVTARKRDKEVLRDVIPPSRGSLSSSGSNDGVAGLELSGLEISTRGMGAQASSYSRYAQSSTPPVGRAGSAGSRRGSFTNSPIAGSPLQGFSVGEQNRRNSLDNPRRGVANGNQPNTSKVSSSPPPFGHIGAFSTYNSHLQTQSRNGHLKVLPNSTPITNNRLDNQVTSNTAPTSNSQQQQQQNSAHNPSGNYVIDYTPPQKVMHSSWNVMGIPPSGKTRGSPSSNQNNTPYKGGSPAYQQSPQGQGQGQQGSPASKQSPGYRNQHWSSNGIF
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MESKDQNVYRKGSDNFSKGSNTFFGNLKSISTTTTTTTTTANTDQQVSKVAENNEIDDNSSVDSSSSNPSSSSTSTTPVKPKTFVDGALRGVWSIGVGVVNGAKGIVEQPYLGAKNNGLGGFVKGVAKGVSGVVILPAVGVLEFFSYTTQGIYNTPITVLDAMKSSPKEEEMITVSAEIPTIFFAVELEESFKTAKEKGIPHLLKVCIEFISRRKNIEGIFRISGSKFLIDEIQSKFDKGLITSVEDLDPNWIYEVACIFKSYFRYLPHSVIPDEQITEFYRIQNNITDATEKAAALKAVVNSIPNFQYTILYECISLLHDISLNSKENLMTPSNLSIVYGPSLLRPNIEKGDIQEIANANTIVFNLISFFQQIFIKNPDPSILEIEHPITPIKPMIQK
The following text describes a protein:
Function:
Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.
Sequence:
MSDDEADPELLELLRQHFRKPTSPETPETRVLESAEYVYNNSIDVALDMTSTKAAAASIYSQMQRKSYSTKTWSSHDLHPQAKDESTVNFIFTMDLLNFSFWSIQNEDERFAIEYKGKKYTGYWSLVAALQRGLEEGYPITSSDYWQNEDELTEDVFAHIFRSCTAEPMPLLTTRLMLLREVGTILYEKYDCAFINCIKESNHSAAALVNLLAASFPCFNDVVSFENRKEVRLLKRAQICVADLWAAFEGESWGEFHDIDKLTMFADYRIPQLLNTLGCLWYAPALESKIKRGEVIESGHSWEVQLRELIRREILKNHPEAKVNAILIDFFLYDTMKERELEGKDEIPHHRTRSIWY
The following text describes a protein:
Function:
Transporter involved in a passive nitrate efflux.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MANSDSGDKEAHRSSKHGGWITLPFMLVTLLGMSITYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISLTGISLLTLIASLDYLRPRPCETGSILCQSPSKLQLGILYAALALVITGTAGTRFILASAGANQYKKPKEQGRFFNWYFFTLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAGKRLYEHDQPLGSPYTSLVRVLVAATMKRKAVISYKDEDYHHRELEKETKTYVAMPSKSFRFLNRAALKTEGDSNNNMWRLCSVQEVEDFKAVLRLVPLWTSVMFLSAPLAVQMSMTVLQAMVMDRKLGPHFKVSAGSMQVIALVSGCVFIILNNWTTYPMYQKLIRKPLTPLQKVGIGHVLTILSMAISAVVEAKRLKTVENSHLMSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRNTATSLTSVVMGISFYLSTALIDVIQRTTKWLPNDINHGRVDNVYLVLVIIGVSNFGYFLVCSWFYKYRNLKNDDHEQDLKDVTN
The following text describes a protein:
Function:
Aldo-keto reductase that contributes to cellular methylglyoxal detoxification by catalyzing the NADPH-dependent conversion of methylglyoxal to acetol. It also exhibits activity with glyoxal and probably plays a significant role in detoxification of glyoxal in vivo. Can also use aromatic aldehydes such as 4-nitrobenzaldehyde, 3-nitrobenzaldehyde and benzaldehyde, and phenylglyoxal.
Sequence:
MQQKMIQFSGDVSLPAVGQGTWYMGEDASQRKTEVAALRAGIELGLTLIDTAEMYADGGAEKVVGEALTGLREKVFLVSKVYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSFAFEETVAAMEKLIAQGKIRRWGVSNLDYADMQELWQLPGGNQCATNQVLYHLGSRGIEYDLLPWCQQQQMPVMAYSPLAQAGRLRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAIPKAATIAHVQQNAAVLEVELSSAELAMLDKAYPAPKGKTALDMV
The following text describes a protein:
Function:
Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Located at the septum.
Domain:
Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains form the DNA pump, and the gamma subdomain is a regulatory subdomain (By similarity).
Sequence:
MSSKTVARSGTRTSRSKATSRGASRSARSAVPRKRSRPVKGVGRPSRRHHRSLLVSTGLACGRAMRAVWMMAAKGTGGAARSIGRARDIEPGHRRDGIALVLLGLAVVVAASSWFDAARPLGAWVDALLRTFIGSAVVMLPLVAAAVAVVLMRTSPNPDSRPRLILGASLIGLSFLGLCHLWAGSPEAPESRLRAAGFIGFAIGGPLSDGLTAWIAAPLLFIGALFGLLLLAGITIREVPDAMRAMFGTRLLPREYADDFEDFADFDGDDADTVEVARQDFSDGYYDEVPLCSDDGPPAWPSAEVPQDDTATIPEASAGRGSGRRGRRKDTQVLDRIVEGPYTLPSLDLLISGDPPKKRSAANTHMAGAIGEVLTQFKVDAAVTGCTRGPTVTRYEVELGPGVKVEKITALQRNIAYAVATESVRMLAPIPGKSAVGIEVPNTDREMVRLADVLTARETRRDHHPLVIGLGKDIEGDFISANLAKMPHLLVAGSTGSGKSSFVNSMLVSLLTRATPEEVRMILIDPKMVELTPYEGIPHLITPIITQPKKAAAALAWLVDEMEQRYQDMQASRVRHIDDFNDKVRSGAITAPLGSQREYRPYPYVVAIVDELADLMMTAPRDVEDAIVRITQKARAAGIHLVLATQRPSVDVVTGLIKTNVPSRLAFATSSLTDSRVILDQAGAEKLIGMGDGLFLPMGASKPLRLQGAYVSDEEIHAVVTACKEQAEPEYTEGVTTAKPTAERTDVDPDIGDDMDVFLQAVELVVSSQFGSTSMLQRKLRVGFAKAGRLMDLMETRGIVGPSEGSKAREVLVKPDELAGTLAAIRGDGGE
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). Dph1 and dph2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the dph1 subunit (By similarity).
Sequence:
MTDAFSSSSEAVLQRSVTSTHSFHPSGDLLLLYQTPETCRFITSNHFKKVALQFPDELLPDAVRVSAEIEDKTKAKTYILGDTSYGSCCVDEVAAEHVGADCIVHYGSSCLSPCRRLPLLYVFGKRPIDVHQCASSFKELYPNLQSHIIVLFDVTYSHAIDDLRTLLCDVYPNVVVSRLKTDHSCGAELIQDSCVDLQSNDDGVIFKFGRQFRIKEGQTVNDYSIFYIGQEGLTLTNFMMSWNNCVFSSFNPETSTGRVESVQINKALMKRYYAIERAKDASVVGILVGTLGVANYLIIIEQLKDTIQRAGKKSYMFAMGKINVPKLANFLEIDIYVLVACPENSLLDSSEFYRPVVTPFEMELACNKHREWTGEYVTDFRELLPGGSSHVGFPEPSQSATEEETTDVSLITGALRSCSTNSSEMMHNSETSSLVLRNQTLTVANTNAAASFLAGRSWQGLEPKLGQTPVVKAVKGQRGIAIAYEEEGNEDASTQQKL
The following text describes a protein:
Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MHRLRVLRHLKFCISTSHRTTVVLKNTRSFCNNIPSTSFASEAAAKYEKKSPTEHVLLRPDTYIGGVAMREDQIIWLRDSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSSMNRLEVWLDRETARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEIKTVGGRNGYGAKLCNIFSKEFIVETVDTRIKRRFRQKWYDNMKKCNEAEVVEILDETVKDYTKVEFVPDLERFQIDKLSDDVIDLIGRRVFEVAATLPRDVDVYLNGQKCDVDGFEDYVKMFNDSSSLLFLHPTPRWHVGVAKRNNFFGESHVVLPKIVSFVNNINTEKGGSHVDYVMDKIVNIIKPIVDSKLGDPTKSVKPAVIKNNLSIFINCLIENPSFESQTKETLTTKAKNFGSIFECDAKKTAEWAEQSGLIEDIVEEVLNMKKKKLPGKRVSVSSVRDIVKLEDAEWAGITGTAEKCTLILTEGDSAKALALAGLEVLGRETYGVFPLKGKLLNVSNLDDARASKNEEISNLLRILGLKFEDSNSITRESLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVHTDGFIQSFRTPLLKAKKGDKVRSFFSMNEYRKWADVEEGGKWKIKYYKGLGTSTSNEAREYFSDLDHHTVNFKYTGTTDDDAIRMAFDRDKSDERKEWIRRSENEITNEDDGKTEISYQEFVDGQLMQFGMVDLKRSIPSLIDGLKPSQRKILWTLLNNMDESTEIKVSQLAGAVAHRQSYHHGEESLVRTIIRMGQTFCGSSNLPLLQPIGQFGTRHEGGNDAASARYIFTALAPTTRLLFPQADDDLLQKNVEEGMVVEPTWLCPIVPLILINGTEGIGTGWSTKIANRNPIDIIDMIRRKIDSISTEYEIPPFYEEFRGKLEVVTPTKFISSGKIQLIRPERKNASTFSIEIVELPIGIWTSKYKEKLSKIVETLPVLEFSERHTEKRVHFRITLDRKKSSRFLQKSNSDLLNYFKLRTSLTENRVLFDRNGELKEFGNISEIAAEFFEVRRDLYEKRLKIQKEECEAKLIYVENQLNFIEMVTNGTIEIRSMGRNQLEEKLQEMGFRVDPMATIAKNSKKANYGYLLEMPVSRLTSDEMKRLEERKSRRRTELEAAESADWKSVWRSELDKLAEAVGNNRKS
The following text describes a protein:
Function:
Functions in the biosynthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNAs. Catalyzes the addition of L-lysine to the cyano group of 7-cyano-7-deazaguanine (preQ0)-modified tRNAs at position 15, to generate q0kN15-tRNA, a q0N lysine adduct identified as 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine.
Sequence:
MEVIKHEGPGRLGVVRLGDYSFRTPALVGIDFTLSPFNSFFHPKEPGEYDFNLAPSIPLGFYTPDEVIQKAIGRLWSVNYDGFNAFYLPALRRTEYLEEFFKIIDRHNFDAVYLGNSKILIKEYRYFVRILRELRERFPNVMIIADLEPFFYPLAVYLGIDAFDTRSLKLYDFEGKGFTQFSPFLWSNEPNSLDFAREVILLVRKALEEGKLRYLVENFFPTQYNAGILRIADLEHPDYLEKYTPIQKETVYFISDASIRRPEVKRWHERVLERFTPPKNVELLLLFPCSAKKPYSFSRSHTLYRRAVKEALGSGTSKVHELILTSPFGVVPREWEWLAKYDIVVTGHWSEEEIKPAAELLAKTLEKYPEDIPIVAHLDEAYVEIAKLASELSGREIIFTDVKNGTTSHESLRSLTETLREFQIEGTKEDRTYRYFENIRKVFDFYFGVGAGEAILPENGQVKGSKMLRIFVEGQQTGTFTDGVISVTPYGMQRIYDALKSYWVKIDFELRGDVFAVGVEEADPRIRPDDIVGIVRDEKVVGVGKAVLSGEEMVRAKKGVAVKVRKRV
The following text describes a protein:
Function:
Appears to promote apoptosis in a p53/TP53-independent manner; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MELEQREGTMAAVGFEEFSAPPGSELALPPLFGGHILESELETEVEFVSGGLGDSGLRERDEEEEAARGRRRRQRELNRRKYQALGRRCREIEQVNERVLNRLHQVQRITRRLQQERRFLMRVLDSYGDDYRDSQFTIVLEDDGSQGTDVPTPGNVENEPPEKEGLSPPQRTTATLDPSSPAPGEGPSGRKRRRAPRAASSLTPELAPVQVGAEGWGQGVIKVEEDFGFEADEALDSSWVSRGPDKLLPYPTLASPPFD
The following text describes a protein:
Function:
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasmic vesicle. Membrane; Peripheral membrane protein.
Domain:
The N-terminal C2 domain associates with lipid membranes upon calcium binding.
Sequence:
MNRMPSLTAQKEEASVFELSVRILQAQNIHTSDTATNPDCYVCLELPTALAEKKRTKTVWNCTDPVWDETFHFRIHSLIKNILEVSLHDEDISTADDHLLTVSYDLGNVPLNKTVLERFILNKERNEELQVEFHIVSIPGTHKKVITNGVLVCPKMAEIEVQVEKQKYKKKLELELTVLGSYEKSHSLFIPKNYTNSNVNETFAFHYPRDLGTEFTASLNRVYSSLDVTFTNETANDTLSQSTLPLTLISSDNNINVQLLATEGKTLGIQLNMKECPEKLDVRLGFNLCDQEKIFLHKRQKVVAEAMKKVLQLKGDLVGEEVPVVAIMATGGGARAMSCLYSNLFALKKMGLLDCVTYIAGASGSTWTMSNLYEDPEWSQNELSEFIHNAKEQVTRTKTKTFSMERLKYYHKELRQAAMEGQKTSFTDLWGLMIESMFHNGKNESKLSDQQAALQNGQNPLPIYLAINVKQHEISTLDFKEWCEFTPYEVGLLKYGASIRTEDFGSEFYMGRLMKKNPEPRICYLQGLWGNVFSLNLIDTWYLTTQVETFWDHWGKDKTNDLDENELRIRKESAHMKTHLFTPPSTFSSILKGILTNRPIDGEQQNFLRGLHLHKDYIHQSQFCTWKDTDLDSVPNKLTPLEENLCLVDAGYFINASFPPLLKPERKVDIIISFDYTLETPLMAVEQTCKYCTTQGIGFPSVSLGEEEKSHHKECYCFVDDDNPHAPIVLHFPLVNDTFRKYKEPGVLRSEEDMPEGDVDVSGYSPYFLTNFTYSECDFDKLMKLTQYNIENNSSTILEALHTAVERRKSKNTFSQMQQTPVKAQQQ
The following text describes a protein:
Function:
May act as transcription activator (By similarity). Plays a role in neurogenesis by regulating neurite pruning between left and right AIM neurons and left and right RIF neurons during larval development. Regulates olfactory plasticity.
Subcellular Localization:
Nucleus.
Sequence:
MNSEPKPGLAMSSHFMGTDNQDQYKGTYAMNRLSIANLLNSPSSTLPTGNDFQNFGLERQINEGVLPQLLQNPWAINFWLQFQNAQLQPHLQYAALACSLVTENPLDLSNKTMNMLQKIGVFNSVTKSEDDESVAPEKPVDESLNKSNILRRNYTVEDLTQAVEDIRQGKLGTRRASVVYGIPRSTLRNKIYKLEAEGAIPSKVRRGKIAARRAEAEQKRCVEATAAAALLDAFGNQSDSSSSSPHASMCPSSPDSTNSSLEGTGETPEMSDKKSCSPLDPKWLESIWQNLFKTQGNVVPVDSANISNVDTHTPTPISEKSQKMHGNEEWKRSRPKRGQYRKYDKNALDEAVRSVRRGEMTVHRAGSFFGVPHSTLEYKVKERNLMRKKKDCLYSHDSSTSEDGSQLVTSTISEKSDSSSHTSTPIPFPISLV