lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
Subcellular Localization:
Cytoplasm. Note=Binds to ribosomes.
Sequence:
MLENLRNIAIIAHVDHGKTTLVDKLLSQSGTLATRGEATERVMDSNDLEKERGITILAKNTAIKWNDYRINIVDTPGHADFGGEVERVLSMVDSVLLLVDAVDGPMPQTRFVTKKAFAQGLKPIVVINKIDRPGARPDWVIDQVFDLFDNLGATDEQLDFPIVYASALNGFATLDPDVVSEDMTPLFQTIVEKVSSPDADADGPFQMQISQLDYNSYVGVIGVGRINRGSIKTNQQVSVIGADGKVRNGKMGQVLGYMGLERTEVDVANAGDIVAITGLGELKISDTVCAAGNVEAMPPLSVDEPTLTMTFQVNTSPFAGKEGKYVTSRNILERLQQELVHNVALRVEETDSPDRFAVSGRGELHLSILIENMRREGYELAVSRPEVILKTIDGELCEPFETLTVDVEEEHQGTVIEKLGIRKAEMKDMQLDGKGRVRVDFVIPSRGLIGFQTEFLTATSGTGLIYHSFDHYGPHKGGDIGQRANGVLISNATGKALTFALFGLQDRGRLFIGHAAEVYEGQVVGIHARSNDLTVNCLKGKQLTNMRASGTDEAQVLTTPITLTLEQALEFIDDDELVEVTPKSIRVRKKHLTENDRKRASRG
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MDDVEKAILISFEESGAIDSALKSQALSFCQQIKETPTVCRICIEKLCFCNLVQVQFWCLQTLHEVIRVKYAMLSLEEKDFIRKSVFSMCCFEVIDDKNNNAVRILEGAPAFIKNKLAQVFVTLVYFDYPLIWSSVFVDFLPHLRKGAVVIDMFCRILNALDDELISLDYPRTPEEMGVAGRVKDAIRQQCIAQIVNVWYEIVSMYRNSDLDLCSSVLESMRRYISWIDIGLIVNDAFIPLLFQLILVSGGSEQLQGAAAGCVLAVVSKRMDHQSKLAILQNLQINRVFGLVTGDIDSELVSKVAALITGYAVEVLECYKRVNTEDAKGVSLELLNEVLPSVFYVMQNCEVDNTFSIVQFLSCYVTTMKSLSPLREKQLHHVGKMLEVLCAQIHYDPIYRENLDMLDKIGREEEEKMVEFRKDLFVLLRSVARVAPDVTQMFIRNSLVSCISSVSERNVEEVEASLSLLYALGESLSDEAIKTGSGLLGELVPTLISTRFQCHFNRLVALVYLETITRYIKFVQEHTEYVPMVLTAFLDERGIHHPNFHVRRRASYLFMRVVKLLKAKLVPFIESILQSLQDTVTRFTSLNHTSNDFFGSEDGSHIFEAIGLLIGMEDVPSEKQSDYLSSLLTPLCHQVETLLINANALSPEESPAKIANIQQVIMAINALSKGFSERLVTASRPAIGVMFKKTLDVLLQILVVFPKIEPLRNKVTSFIHRMVDTLGASVFPFLPKALGQLLAESEPKEMVGFLVLLNQLICKFSTSVHDIVEEVFPAIAGRIFSLIPTEPFPLGHGTNSEEIRELQELQKTLYTFLHVITTHDLSSVFLSPKSRDYLDKMMQLLLQSACHHEDILVRKACVQIFIRLIKDWCTRPDVEAKVPGFRSFIIDGFAKNCCFYSALDKSFEFHDANTLILFGEIVLAQKVMYEKFGDGFLIHFVTNCFTTAHCPQDVAAQYCQKLQGNDMKALRSFYQSVIENLRLRQQQNGNLVFR
The following text describes a protein:
Function:
Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
Subcellular Localization:
Mitochondrion.
Sequence:
MCGSGALSTETRLALHPHQVPTKMLASSSSKLAARASRSLFTKASAMPSVALSEEFPAVPKTQPQATAAPKLTASKASSGLALGSDDRAAPVATIGVQLSTGSRDESEDTAGVSQLFAKMAFRATATRSDLRLYRDVEAIGGVVHAQAGRDFVRYSVSVLPDQLEAAAEILAETTLAPKFALYDVDEQKKIVQAEVDRIGDDASASLLEGLHAAAFYEDLTLGRPVAAADNLQALSPEALWAFHDKYVNTANAALVGAGVNHSTLTDLANEYFGSFAKGVEAASATAKYVGGETRVKKAAKFTHVALALPTVGRDSADFGASQVLRALLSLRLNNKKASAFLSSYSDAALVGLSGYAVHSEAGALVDSFAAELKKAASAPATKEELAAAKTTAALEALEQYSTQTGTLGRVGLIATTGFVSQSPSALVEGVTAAKLQELAQKALKATPSVAAIGKLSAVPHVDAVANKLQ
The following text describes a protein:
Function:
SNARE required for protein transport between the ER and the Golgi complex.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MTELLRARLDGLISNTEQNIASLENESSKLTVTGLATTIPKLFLSLKTLIEESEDALLDIKRPSQKAALAQSIAQQKQAVKLLQQRFQTALVTARKAIKTKAQNDRESLLALGSASKTDRSNAAAIQASNDITYGLKQAVQMISAEVERSIETVNTLEQSTNTLNRTQQEYSMIGDRLGVSKSIISSLNSRDWMDRALLGVGLLVFTLTMMYIIGRRMWIPGYAWISGECAMSTSWFCF
The following text describes a protein:
Function:
Antimicrobial peptide.
Subcellular Localization:
Secreted.
Sequence:
MFTLKKSMLLLLFLGTISLTLCEEERDANEEEENGGEVKVEEKRFIGPIISALASLFGG
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
VILAGLLSYADGGTAAGYVALYLVGWSPLLWSIGYQLFSPERKEVLSLSQPSMQSFIQFIWFWIRRILNPPIYGTLIGLVIGATPISYFFYPSKGKFLDIHQSSEGFRVLHEGLVLFCQSIMEASSLLGSATVTVQTIILACAIGPLISDFGLRKGDPYETDKQSGEFNREKGYTIVLDKHIFWAIICIRLIGMPLAILFLVKGLLHMGLLPMNTILVFTILVLSAMPTAQNLVVMLQLNPSKAPLVETFANLLLYEYGLALASIPIWTTVFTAVFSRP
The following text describes a protein:
Function:
Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAATSTAAVDQLAADLGNTSLDNKAAAPAPIDTSAVPEAQAEGAEAAPTPTAAPHPQASASLYVGELDPSVTEAMLFELFSQIGSVASIRVCRDAVTRRSLGYAYVNYNTTADGEKALEELNYTLIKGRPCRIMWSQRDPALRKTGAGNIFIKNLDAAIDNKALHDTFAAFGNILSCKVAQDEHGNSKGYGFVHYETDEAASQAIKHVNGMLLNEKKVYVGHHIPKKDRQSKFEEMKANFTNVYVKNINNEVTDEEFRELFAKFGEVTSSSLARDQEGKSRGFGFVNFTTHEAAAQAVDELNGKDFRGQDLYVGRAQKKHEREEELRKSYEAARLEKANKYQGVNLYIKNLGDDVDDDKLRAMFSEYGPITSAKVMRDSLIEGSEEKDEKDKENKKEGETKEEEQNEGSEKKTEKKGDRKLGKSKGFGFVCFSNPDDATKAVTEMNQRMVDGKPLYVALAQRKDVRKSQLEASIQARNQLRMQQAAAQAGMPQQYMQAPVYYAGQQPGFMPAPGGRGVPFPQGGIVPGVQGGRPGQYPYQQGGRGGVPPQQMPPMGYPINQFGPGAFPPNTPQYMAAMGQVGALGGGRGGPAGRGPQGIPAGIPQGLQGGPAVPGYPPAGRPQNGGGRGTPRGNANFMAAGRGASPIPGAPADLSAGSFLQAQLATTQDPQAQKQIIGENLFPKIQAIQPALAGKITGMLLEMDNAELINLFEDDNALNVKVQEALAVYDEYLKTQGQQPTQQPAEANGEQPKAEEQKPEEQKA
The following text describes a protein:
Function:
Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level (By similarity).
Subcellular Localization:
Membrane.
Sequence:
MNDKISKLESSILQLTEEVKQLESKQASKELEIRTLVDNAINSQNPAQERELINKLFTESLIDLKLKAEKIQTLERYRQEIITNLLVEQKQPNDTSIISAWEQLKISSFRINPNNNNNNSNNTNSSDSNQNYSSVILNGSLTEDSTSTISPDSTKNRDEEEIIRWEIDRNEISYNREAKLGSGAFGSVYKGIVRGKEVAIKKLTQTVFEENTMNEFKKEVSLMAKLRNPHLLLFMGACTAPEDLSIVTELMPKGSVHSLLRAKEDTSDFITFKRAILIARDTVLGMTWLHASNILHLDLKPANLLVDQNWVVKVADFGLSKYMKPDSKDKLLGQAGSPLYMAPEMLVNQPYDGKVDVFSFSILLWELLTKQEPYNKLYSSYPQLVEGVVNKKNRPIIPDYFPTRLKDLLARCWDHYPSRRPSFAEISKQRILETILIDGLILDSSARQFWSQYYMGKEEVPWNSFIVNFSLYCGFESNLSADDIKIKFLKLLLVPVDSDMVTIDNFGKILTWVGPLTNGREFFDKVYSICSIKGFMAATSSKNASQYLAGKKTGTYILRFSSDPGSYAISYLNKNKEIIHARVIYKQGSGYIHHGGQTHYATLDDLIKNTFKSLGIKEPFEGGPFHALTVAASSSKPFNIAGAYIPVAPSKKI
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MINRVSAKWTFPAEALSALVAIGLVTAATSFGIKAMQTYENDDKPHRWGVDKWDRRMMERDGRLTGNVNVQMAEAKAPLQFSRNSAWELEPRLF
The following text describes a protein:
Function:
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Sequence:
MKLAHLHFPDITSFTRVAHLQQILTNRLLAYKRLSSPATANTGAIQPSGVNSPPPDPTIITFTPNPVYTTGRRDLPPSNTAPFSPSAPLSLPPSLEPIRSILTAPPNGSPRAEYHPTLRGGQTTYHGPGQMVAYTILDLRRLGLTPRCHIRLLENSVIDVLRGYGIQGFVTEDPGVWVRPRPATNTAAAMAVSAGGDGDADGVLPKKITAVGVHLRRNISSYGIGFNVTEEPMWYFQQIVPCGLEGREATSLEGEGVPGVSTGEVADKFVDAFVQRVNADFACGGRATGEKIEGVYNVREEDLLQQ
The following text describes a protein:
Function:
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
Sequence:
MAAGMKGKRSRRRKERKNVEHGCAHIKSTFNNSIVTITDSVGNTLSWASAGGLGFRGSRKSTPFAAQMAAETAAKAAMEHGLKSIEVYVKGPGSGREAAIRSLQAAGLEVTLIKDVTPIPHNGCRPPKRRRV
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MENNNNKQNVKNRNNLKIKFKEDFCNDSTEVEQQPPSNLSSPTSYIQGNKLYFNFYDNISNNVSNNYSYNCNNKNNNNNNNKNDNGNYYFFNSENILKNNLQQNETKNSCHHLNQSYNKIEFQNNYQSDYQSDNQSDCQSDNQSDNQSDNQSEIQNNKDGNESVVPPKVKKTRSRKTKEHKDQLENLFNSNPFPDAIEKEIIAYQFDMSVEQIVTWFKHKRENLKKAQHLEYKQNSTKKFTKTTKELYVYFENYPFPQEERVEYFAKSYHTSNEKILNWFSKKRYSLRKTHSFIYDKGCGLYKYENSNFNFCSHFPEKKFDINFINN
The following text describes a protein:
Function:
Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MSAPLKHPNAVVLQPPTVTISPLIRFGRYAALSLGVVYGFFRLRQIREYHADIREWDHEKAVAAAEEAAKKKKWLAKDEMRYLMQVVNIPFEEGVKQFGVADLYKED
The following text describes a protein:
Function:
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
Sequence:
MSTEAGNVIAERVGNKGVITLDRPKALNALSLSMIRQIYQTLKKWHADPGMKMVIIKADKDSKAFSVGGDVKAVVNDQDSNLRDIFFREVYILNNLIGYFPDVGSSYVLPRLPGKLGLFLGLTGCRLVGWEVFKGRIATHFSSSQRCETEFRKELDFEQLMGRINSAFSAPSVDAIVENLSKDASEWAQEQAEILRKMSPLSLKVTFRAFQEGPGLTLQDALKMEFRLCQHFMEDSDFYEGVRAVLIDRSGEPKWNPATLADVTEEKVNSYFAPLPADRELRL
The following text describes a protein:
Function:
Odorant receptor.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MCQQILRDCILLLHHLCINGKKVSPVMLGPAYNHTMETPASFLLVGIPGLQSSHLWLAISLSATYIIALLGNTIIVTAIWMDSTLHEPMYCFLWCLLAVDIVMASSVYQDGEHLLLRRQMGLLLIMAFDRYVAICKPLHYKRILTPQVMLGMSMAITIRAITFMTPLSWMVSHLPFCGSNVVVHSYCEHIALARLACADPVPSSLYSLIGSSLMVGSDVAFIAASYILILRAVFGLSSKTAQLKALSTCGSHVGVMALYYLPGMASIYVAWLGQDIVPLHTQVLLADLYVIIPATLNPIIYGMRTKQLRERIWSYLMHVLFDHSNLGS
The following text describes a protein:
Function:
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEREHNRMHGTSRRDAVSESSSPTARSLGVFLSLDSSSQRIFMRTASLGRIGGTGYWQLGSIRPNLIVEGIPADTTRPAAAGDNQAIGAEMAGNGLKQGSLSRMSSRDSWPRGSISFSSDRGTIDNLALPQELIDKIDSSLAQVGCRGSRVDDKEHEDGVVTFADDSLILSFNSRSYEANLPSVVTPLTEEIVSPLPTDSILSTTGKGQMTGIASPKDKQYKLPFWLDYISYLSHLAVFGILGVYTRYLLQKLFGPGLLRLTGDNPLYLDLPSNMIGSFLMGWIGFVFKADILHVSEHLLVGLSTGYLGSLTTFSGWNQKMLESSSKGHWVYTVAGLILGTFLVNYSIIVGVGCAGGLRRIIIDWCEKRTTNLEKWRVDNRNKHVVVMAAFLLIWCLLWTLSGEFFRVKLNRVSNSAVLWLAFLVGPPGVWLRWRLARFNGQGIGSKRMLKWLPIGTLSANVLAAGIMAAVAIISKAVNTKRCSIIVSGFQLGFLGCLSTVSTFAAEIYGMWKTGHGWRAFFYIIVTIVPSFALGTLVYSVPIWFKHYES
The following text describes a protein:
Function:
Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MGCFFSKKAKRKRNSEEAKAGEQPQQDGEEPKQYSWDKREKVDPKDYMFSGLKDQTVGKLPDKVAGQQFVIQECENCNIYIFDHSATITIDDCTNCRIFLGPVKGSVFFRDCKDCKCVVACQQFRTRDCRRMDVFLCCSTQPIIESSTGMKFGCFQYYYPELALQFKEAGLSIFNNTWSNIHDFTPVAGETNWSLLPPDSVIQDFIPLPDSEELKCVRVSADIHKSIIPVTWGQRLKKSDESCLVVFFAGDYTTANARKMIDEMVGKGLSLIQTKEVAMKTEDAKRVFQDKVTDLISLVEKGPVVALEFNGDGAVDNCQSVISNTFSGSKVFVSESKESASRDVDNFYNFADMQMGM
The following text describes a protein:
Function:
As a component of the inner core of AMPAR complexes, modifies AMPA receptor (AMPAR) gating.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Synapse.
Sequence:
MKTSRRGRALLAVALNLLALLFATTAFLTTYWCQGTQRVPKPGCGQGGGANCPNSGANATANSTAAPVAASPAGAPYSWEAGDERFQLRRFHTGIWYSCEEELGGPGEKCRSFIDLAPASEKGVLWLSVVSEVLYILLLVVGFSLMCLELVHSSSVIDGLKLNAFAAVFTVLSGLLGMVAHMMYTQVFQVTVSLGPEDWRPHSWDYGWSFCLAWGSFTCCMAASVTTLNSYTKTVIEFRHKRKVFEQGYREEPTFIDPEAIKYFRERIEKGDVSEEEDFRLACRHERYPTRHQPHMGDSWPRSSAHEAAELNRQCWVLGHWV
The following text describes a protein:
Function:
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45' (By similarity). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (By similarity). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton.
Sequence:
GEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY
The following text describes a protein:
Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24. Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1. Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes. Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Mitochondrion matrix. Note=Translocates to the mitochondrial matrix following induction of MALM (mitochondrial protein catabolic process).
Sequence:
AAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEITAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGG
The following text describes a protein:
Function:
Axoneme-binding protein that acts as a regulatory component of the outer dynein arm and regulates ciliary motility.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium. Note=Localizes at the base of outer dynein arms.
Sequence:
MAPKKKEDKDAPPPEDTNPYGVFVSVTMPSATVVLDVQDDAAAQRETHITLNIPGCHVPWASAHTAPSEGGVYQYSVVKHFRRSGGQDGLLQLINGVLTVTVNDSATNAVLASATVDQLQGFAIGQNTWSTEGLDLVPAAEVPEGVPKARSARLAFASIALQERPLPEGADAAALAAAPPPPEAELPPLLPYSYVSGEAAEKGNMVELVVSGLSPLPPNLQAAADAAGGKLHVTVGLALPGGGPAVAVSLAVAGGRVAAPAFRRELLPPGCLQALQYALEDGLPVVLEVARYVSAEGMADPAFEGYHAAAAAPALAAGLGAAGATEAAAEGLSLTAWAASGAKTCLPPYTAPAGKPKPVEAEVPPAGTCLWEKAGAQLAVSLRFARPVVPAWRPPPPPPRPLLELIPPRDLTPKPPPTTAVDEFKAKVRVIARALAEEYKAVLPPPDASVAAAAAGGGAEGRHKALIFELNRSGKYAQMRDSLKTAVVSLVREKYRKSGSMSPNEMALLYNDLYGSLLAAVHSSLNDLVDAAAARPRAPPPAPVPDKQRLGELLELAAQAEAMGDTDRAELLHQRRLLAKNDAQVWYEYGTYCLRRGGAKRGRAEECFREALALEPAHRGALLALLGCSVAAGRNTDPAYLESAEAAAHRLLDVAGRSSLDAWAALAVVYRAYGEAKRAELASCEQEMARLEKQQLAAAAAAASAGVSPSPSYGEGRAGGNGGGVPATEPSTASAGSVAGSAGELQARSFISLANTLLESLALPAEAALALELAAGLRHWPSVGPDTRTLHALAGALAEQALARAAGGGAASAAAEAMLTPGSSVLSMMRADAGEAVSSVAAEAAWRCRLLVAQLHKARGATDEAIRFYQSFIAITQQHAPSTPPPPPPPPPPPPPPPPQEYIEAARSSGRLAEVPLSAWLELAEAYAARGQARFAADVFLLGASARPGCAVLWRGAGRCFVGAEELGPADMALSEANVLDPEDPEAWGWLALVALREGRAEDAEKALAFGLRCGLGDPGLLLDIAAEYRAAGQRRAEQRVLQEVAVKLMPESCSARLLLARCLVAQRCGAEAAEAVAAARQLAAHEDDEAAVAELEAELRGMA
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes; Regulates also the sphingolipid metabolism.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGKLGADASMRCVHCGTPVAAVYVEYSPGNIRLSECAKCGFVADEYVECEIMIVVIDLILHKPEAYRHIFFNYPLLHKLKMLEFVWKTSLLVLLLDSCKLCLRGVGKTDVRWESLSLFLSTAGKVLAKVGLANVVFLITVLALAYALPNLGPHAKSKWTDLLMAVALSSYFKMFVFAMMVWEYSPLMTLIIDMLVLSSNTVALKVMLNTSTPIAATVIAAAAFFRTLCRISIDFVL
The following text describes a protein:
Function:
High-affinity transporter for external inorganic phosphate.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKLNIFKSHGDSNTAEERPVPLEQVEAEDQQHENRFWLGLTAKEFRLMMLAGVGFFLDSYDLFIINLVTPIFEYLYWGGIEKGPNGKGHYPSGIRGLVNAASNIGNIFGQLMFGFMGDFFGRKFVYGKEMIIVIIATILLIAMPKSIHSPLSKMMWVFCWRWLLGVGIGGDYPMSAAITSERSKLNRRGTLISLIFAFQGFGTLAGAIVTIILLGCFEHPLNREGHYRKLEGVWRLQFGLALVPAIGVLIPRLMMEETQKFKNSQQLNSGDNRDPKTSLNFEDDELVKNPSVTKGHPEIHESSENYLSRSNTVENEPENIEKQFESVSAPANRSGFIQYFRQWHHFKHLLGTSVCWFLLDIAFYGVNLNQSVILKNIGFSSGTNEYRTLMKNAIGNLIIAVAGYVPGYWFNVFLVEILGRKWIQLQGFVITGLMFAILAGRWNEISTGGRFACFVIAQLFSNFGPNSTTFIYPAEVFPARVRGTAHGISAALGKCGAILASLLFNFLTSIIGYGNVMWIFCGCMWGGILFTLLLPETKGRDADEIDRVELFYGGDGKVECNSKWKSWYVNGIF
The following text describes a protein:
Function:
Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR (By similarity). Both isoform 1 and isoform 2 promote apoptosis.
Subcellular Localization:
Cell membrane; Single-pass type III membrane protein. Nucleus. Note=Proteolytic processing gives rise to an intracellular domain that translocates to the nucleus.
Sequence:
MLHNVSKGVVYSDTALKGQDGDREGMWVGAGGALAPNTSSLFPPEPPGASSNIIPVYCALLATVVLGLLAYVAFKCWRSRKQRQQLAKARTVELGDPDRDQRHGDSSVFVDSPHGLEPCIPSQGPHADLGCRLYLHIPQQQQEEVQRLLILGEPAKGWQGLAGQLGYQAEAVETMACDQDPAYALLRDWAAQEGSGATLRVLEDALTAIGREDVVQVLSSPAEGCSVV
The following text describes a protein:
Function:
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).
Subcellular Localization:
Cytoplasm.
Sequence:
MAHLKLDTLHVQRSPRGSRRSSPSSGRSSACSSGSISPVPIIPIISISHDGDESESESEIETEPARLFQRRMSTKCTNNLAAIIKEGFLLKHTWSFQRWRRRYFRLKRNMLFYAKDEKCDVFDDIDLSDLCYFECGIKNVNHSFQIITPTRSLVLCAESRREMEDWLGSLKTATAPQRPRGDSFLIEQHDILSNHHHWYATSHARPTYCNVCRDALSGVTSHGLSCEVCKCKVHKRCAAKSIANCKWTTLASVGKDIIEQADGIIMPHQWMEGNLPVSSMCAVCKKTCGSVLRLQDWRCLWCRATVHVACRPQMAVACPIGPAKLSVVPPTSVHSISTDDAWDVASPKGNFSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLISTGPSLGLRLFRHFEMFRILVCSGDGSVGWVLSEIDRFNMHKQCQVAVMPLGTGNDLARVLGWGSSCDDDTHLPQILERYESASTKMLDRWSIMVFEKAIPVPKTPKMSISTEQEAMLTGMVTSANHHLRFIVETNDTQTLIRSTRNLCDTVDDLVCRISEHHKDDEQLAVKCDILRQKLNMLLDALQEEEIGAHSGDDLIATIRSLIARSIPVTPGSNAYLLNPNISIEKTEKDQINTKERRNSRSLRSSEKEALQCRANSVKRAIYNVVEHSEPGRPKRYQRKLSITPFEALKLPTASGESTPCTSPLPIIPPINIISPTMETSRLTCISPLPDTRRDSVDENFFNSINLPAPRQFADSRRSSGVEVIQEIEEGANGETVYRKSRMSLTGGANIDDAGNRLSPCSDAGENTPTERKVDFLRVPIHTGEPIVDPLCDYRPHEVFERTYYMTREMDKGKEKDKEKDKPVEIDKEKDTCVEKEGSMPAEKLVHTCNLQVPGVVVTPNPQNVYSSASITIIDTDAQTTTEQSSSDDLGGEASDVLSAISNEECSVASEIFDKQDAGQTVGDIIQNMDASNFTHIDSPETSDETEAMPGESIMDDISSVLGHDITYALQDNTLTDDTTTLCSEHAGPPKPPRKKSLSALSRTQAHPRRRNSSPPRMARLARMDSDDNPQQFGFENIVFEIDNRCDDQKMREPPRYCSLAQFVEGNDIARQSFKQLMLEQHRGGDNDSDYPEHEQTPTNKGANLLATTSEDELSTQTAIKIEIQDIDATVRNLNSSMKPNTILTTSTSPTKKSGHGQDVKRITFDESCKKESFDDVNPNYPQISVVVRPPTPLRGDCIKPTVSLLPVSSGGAMTVSMTCSGMLGVRAMNASEIRRHSSHAPGLAVREFDKDKDRRHSGFNPNQLTLDPEHARFLSSSPAASRRISCGSLFKPNEALPNLQTLKGSKSSLFMGSTLFGFDHLASAEKDKEEKSGKDKEKTPTDETNRKLPIINPLVRLPNWPNLANGGGFISKCLLANADTLCAAVSPLMDPDETLLAGYHEKCVMNNYFGIGIDAKISLDFHNKREEHPEKCRSRARNYMWYGVLGSKQLLQKTCKNLEQRVQLECDGQRIPLPELQGIVILNIPSFMGGTNFWGSSKKDDIFLPPSFDDRVLEVVAVFGSVQMAASRLINLQHHRIAQCQSVQINILGDEEIPIQVDGEAWLQPPGMIRILHKNRVQMLCRNRSLELSLKSWQEKQRQHSISIQRDASSTASEHANSTDEVISERECYVLLNFIEAVSSLVKWVKFLIISHPALQHDLYEVACRASEALESIHPQGKLLEGPSLRTKLVEVIDSSRQLYDDACTLLRDRGHSLILREDLETKLSAALANMEMELKKCSVQKCIDGKLRAYFNVLAPNEESDGRRKSRPFWVRLRSGSTAGQQAFKPPLTNTREAANNWSVNEVVTWLETMQLSEYVDSFLKNDIRGKELLTLGRRDLKDLGVVKVGHVKRILQAIKDLSEN
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MKDIQVRRMDEIDGWRQKAFVLSRTDRLGRLITKTFDLILSVVRDGPNAEILLYDIESLRSEQATEIKFDSNRDDIYRSLFYGLSTSLGSMIESIQERKEDSLETAENAKEVVIQITQDKQNTAYLNNADENDQDNQYFLTGTSKVEPMESRHNLTLDAVDFNLEDLKSEPLTDHYEIDNFPVDSTSDEFVEILDSSNAYNNTDGAADESKDARDKIDQADLSYRLKCGDCGNGVKNREKLLQHYAEFHPGQKVKEAESSARKSLQCARCDYKAHFQSNLTVHMHTHTGEKPYACSQCPKKFAQTSNLYAHMRACHAEMTHDRMLGGRKRKNEKTGGPTKD
The following text describes a protein:
Function:
Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MSILDYFDYFNYVNNWTLAALGIGIALLLPGIMGFLGLGGNKFVVKGKTVLLTGASEGMGKSVAIQLARKGANVINVARNVGKLEMALREIEAAALFPSTQFFHYISADVSIPTEAARILEEAIKLNSSTPPDIVWCIAGTSTPGFFLETTPQKLRTQMDINYWSCADMAHCVLKSWLSTPNVEKKERHLIFTSSVVAFYSIVGYTSYSPAKAAIKSLSDTLYQEVLMYPNPPQIHTVFPGTIASPGLEIENQGKPEVTHLLEETDPIQTPDEVASNAIKGLERGEYLITVGWLGSMMRACAWGGSKRGNWVLDTLITWGTSVIWGFVGSDLDGKVRKWGETKGFARG
The following text describes a protein:
Function:
May modify wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9.
Sequence:
MDEAASQLEREHVHSVYERIAPYFNDSRYKAWPKVKQFLLEQEPGSIVADIGCGNGKYLHINEEIFKLGCDVCRPLVESAWNKGHEVQICDGLRLPYRDACFDAVLSIAVIHHMSTKERRIRAIKEMARTLRVGGRIMIYVWAMEQKRRKFEKQDIFVPWNPNPPLSPALKGTRQRGNGTQSVSDETASGDKYRKVRSTSSMLDEGDLISPSQQKQQRLWFFSRSLDSVLDFGSLTLSRSSSSTLQTETVENRNRRGSGRGLIRQMSSLFSSSSRTSLEEDVFISDSNETVRKIDNRSAGNGNVELVHECSSVPLPDLVSYQKDQSNLEGQEEESSLREPLRRKESSSSLLEVDGMKGEQPKDSCLRYYHVFREGELTQLIQNHVDDLHVLHTFLDHANWCVVAEKIQVWKV
The following text describes a protein:
Function:
Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MAAVRSLRVSVKSDSASDRSESDSESDSDRDAREAEPMEVEEGEVELESIPVRRSLKELLPDTSRRYENKAGTFITGIDVTSKEAIEKKEKRARRFHFRAEENLTQKDVVLERDLLKKMIPKVRLEALHMSGVDDMSTQDVFGYFKEYPPAHIEWIDDASCNVVWLDDITSTRALINLSRMPDKEEVTNTDSSKPSELPVQTQKARRSRGSDDDDDDDEEEEGEVDDDDDDDEEDEKARDIEDETEKKPQETRETSLSQAERDSLLQNEPRPTVKPFKGNKLFLRFATHDDKKELGAARRSRYYMKYGNPNYGGMKGILSNSWKRRYHTRRIQRDILKTKKPLIGDSMGHTPPYTHRHSADLVNLPEEPIEEEEEEEEDGEEDMDADDRVVEYKDRGEKERGPRLVEGGLRSRLGGPSPTSSDSDEMDYDLELKMISTPSPKKSMKMTMYADEVETNLRSLRNSIRTESSGSVKSRIGGGGGGGSGGAVEGRGEGGSSKSTSEKVTDVRQLLEEKRQGLSQQRSRPPVATSGKTDVRQRLGKRPHSPERRRSVSPVISRKTASRREPLSDVRSRLGVAKHDNRSLFSEPPKDKKTGGLWSRLGPSHKDSGSGDEDKPSSRASSSRGIRRRKDEDSDGVEDEDEEDDSHLQKMWGAMIKQKEQQSNKMKKSRLDNLPSLQIEISRDGSNGSDSDS