lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Apical cell membrane. Cytoplasm. Note=ABCB1 localization is influenced by C1orf115 expression levels (plasma membrane versus cytoplasm). Localized to the apical membrane of enterocytes.
Sequence:
MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ
The following text describes a protein:
Function:
As part of the exocyst, may play a role in regulated exocytosis of insulin granules.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle.
Sequence:
MDSAAKDEMQPALSPGPEWPEQERAEQLARGAALKWASGIFYRPEQLARLGQYRSREVQRTCSLESRLKSVVQSYLEGVQTGVWQLARAIEVVQGTREALSQARGLLQGMSQALQTLEPLRERVAQHKQLQALSHLLPRLRAVPAAVSHTQTLIDGQQFLEAYVSLRELEQLREDTWAPLGGLELPVFQGLDLLFEALGQAVEAAAGAAGKLAREDPALLVAAVRVAEVETGRTTPLGQVPRDWRQRCLRALQEGLERAHFGSPLLPAPGALPGWLEALRVALPVELATAEALVAPCCPPQYNVVQLWAHTLHSGLRRSLQNLLAGPELEAADAFTLLHWALHVYLGQEMMGSLELGPEADVSQLEPLLTLENIEQLEATFVANIQASVSQWLQNALDGEVAEWGREQGPNTDPSGSYYSPMPAIVLQILEENIRVASLVSESLQQRVHGMALSELGTFLRSFSDALIRFSRDHFRGKSMAPHYVPYLLAALNHKSALSSSVSVLQLDGAPSGALAPVEAALDELQRRIYRLVLEALQAELQPLFADLPSRQWLSSPELLESVCERTGRFCRDFWRVRNPTVQLLLAEAERAVVLQYLSALMQGRLVCRGADERTQAAERLRHDAAQLQQLFLSLGLEENAHCAPVLLALRELLNLRDPALLGLEVAGLRQQFPDVSEDHVSALLGLRGDLSREQHLAALSSLQAALPPSPRASRRVLFSLVPAPALAPASCLPSGSCARALLLAE
The following text describes a protein:
Function:
Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDSDIKECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF
The following text describes a protein:
Function:
Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (By similarity). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (By similarity). MSL2 plays a key role in gene dosage by ensuring biallelic expression of a subset of dosage-sensitive genes, including many haploinsufficient genes (By similarity). Acts by promoting promoter-enhancer contacts, thereby preventing DNA methylation of one allele and creating a methylation-free environment for methylation-sensitive transcription factors such as SP1, KANSL1 and KANSL3 (By similarity). Also acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A (By similarity). Also involved in the DNA damage response by mediating ubiquitination of TP53/p53 and TP53BP1.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with both promoters and enhancers of target genes, maintaining promoter-enhancer contacts.
Sequence:
MNPVNATALYVSASRLVLNYDPGDPQSFTEINKLLPYFRQSLSCCVCGNLLQDPIAPTNSTCQHYVCKTCKGKKMMMKPSCSWCKDYEQFEENKQLSILVNCYKKLCEYITQTPLARDIIQAVDCSADLLALLKDGSPLHEETEKSSDTALALCLTHSPVPSTSELTSDPPATLTSKPESTQNVDIRGSVINGLPNCNGLSVDKLGVNIPSPEHANTIDVCSTGEYMKNEDNSSSLQPVCDPVSTSDLCTTGIDICSFSEDIKPGGSLLLSVEEVLRSLETVSNTEVCGSNLQPSLEANVTNGPFLQLSPPPLSHNIFVSTDASPHGISCTAATPKVVKLNRKRSRSESDSEKVQPLPISSIICGPTLGASAPVTVKQENKMSLQPVATVPNGGTTPKISKTVLLSNKSVKKNLEHAPKKSHPKAKPGVLKTKDKAKEKVPSSNVMPGSPTKTVYKKPQEKKGCKCGRATQNPSVLTCRGQRCPCYSNRKACLDCICRGCQNSYMANGEKKLEAFAVPEKALEQTRLTLGINVTSIAVRNASTSTSVINVTGSPVTTFLAASTHDDKSLDEAIDVRYDC
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Microtubule-associated protein which regulates cell division and neuronal migration during cortical development (By similarity). Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (By similarity). May enhance calcium influx through CACNA1E and stimulate programmed cell death (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MVSNPVHGLPFLPGTSFKDLTKTAFHRSQTLGYRNGYAVVRRPTVGIGGDRLQVNQLSQADLDELASKIPILTYGQARQAPPAAFVPAHVAFDKKVLKFDAYFQEDVPMSIEEHYRIRQVHIYYYLEDDSMSVIEPVVENSGIPQGKLIKRQRLSKNDRGDHYHWKDLNRGINITIYGKTFRIVDCDKFTQVFLESQGIELNPPEKMALDPYTELRKQPLRKYVTPTDFDQLKQFLTFDKQVLRFYAIWDDTDSMFGECRTYIIHYYLMDDTVEIREVHERNDGRDPFPLLMNRQRMPKVLVENAKNFPRCVLEISDKEVLEWYTAKDFIVGKPLTILGRTFFIYDCDPFTRQYYQEKFGISDLPRIDMSKKEPPPMKQELPPYNGFGLIEDSAQNCFALIPKAPQKDVIKMLMNENKVLRYLATLESPFPEDKGRRFVLSYFLATDMISIFEPPVRNSGIIGGKYLGRTKVVKPGSSVENPVYYGPSDFFIGAVIEVFGHRFVILDTDDYVLKYMESNAAQYSPEALLSIQNHIRKQEAPAPELDGQQAEEDPGVRDLEALIDTIQKQLKDRPCRDNIREAFQIYDKEASGYVDRETFFKICGSYQLPVDDSLIKELIRMCSHGEDKIDYYNFVRAFSN
The following text describes a protein:
Function:
Transcription factor that may be implicated in patterning of the central nervous system during early development.
Subcellular Localization:
Nucleus.
Sequence:
MATTASNHYNLLGSGSSIVHADPGGMQQAQSYRDAQTLVQSDYTLQSNGHPLSHAHQWITALSHGDGAPWATSPLGQQDIKPTVQSSRDELHGSGTLQHQSRAPHLVHPAHGNHHGPGAWRSTGSTHLSSMASSNGQGLLYSQPSFTVNGMINPGSGQGMHHHGLRDSHDDHHGDHGHQQPSQTQQQQQQHSQLQGGHHDHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPAAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTIPGAEDVYGASRDTPPHLGVQTSVQ
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
RREPPRPLPLTFEDVAIYFSEQEWQDLEAWQKELYKHVMRSNYETLVSLDDGLPKPELISWIEHGGEPFRKWRESQKSGNTICSSVDKHFDPGFEEQLFWGSQQAMNSGKTKSHFQLDPESQCSFGSFVSFRPDQGITLASPQRHDARAPPPLACGPSESTLKEGIPGPRNLDLPGLRDVPAWESTQHPWPVCGESCWENNHLVMHQRGHSKDRTRRAWEKFNKRAETQMPWSSPRVQRHFRCGVCGKSFRRKLCLLRHLAAHTGRGPFQSADGEMCFRHELAHPSHRLPQQGEKPAPCTPCAKCSLPVDSTQARRCQHSREGPASWREGRGASSSVHSGQKPGSRLPQEGNSHQEGDTEALQHGAEGPCSCSECGERSPMSARLASHCRAHTGEKPFQCAHCTKRFRLRRLLQVHQHAHGGERPFSCRKCGKGFAKQCKLTEHIRVHSGEKPFWCAKCGRNFRQRGQLLRHQRLHTDEKPFQCPECGLSFRLESMLRAHRLRHGGERPFSCSECGRGFTHQCKLREHLRVHSGERPFQCLKCDKRFRLKGILKAHQHTHSKERPFSCGECGKGFTRQSKLTEHLRVHSGERPFQCPECNRSFRLKGQLLSHQRLHTGERPFQCPECDKRYRVKADMKAHQLLHSGEMPFSCECGKGFVKHSKLIEHIRTHTGEKPFQCPKCDKSFRLKAQLLSHQGLHTGERPFHCPECDKNFRERGHMLRHQRIHRPERPFACGDCGKGFIYKSKLAEHIRVHTKSCPAPNELDIKKRLSQLFAMIEADWS
The following text describes a protein:
Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINCLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQGLCDLWLSVDIICCTCSILHLSAIALDRYRAITDAVEYARKRTPRHAGITITTVWVISVFISVPPLFWRHQGNSRDDQCIIKHDHIVSTIYSTFGAFYIPLVLILILYYKIYRAARTLYHKRQASRMIKEELNGQVLLESGEKSIKLVSTSYMLEKSLSDPSTDFDRIHSTVKSPRSELKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNICEKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRN
The following text describes a protein:
Function:
Activator of apoptosis, independent of rpr and hid, that acts on the effector Dredd.
Sequence:
MAIAYFIPDQAQLLARSYQQNGQQTAASPRTTATAAAPSQQQQQSQQQQQQQRHHHQQQRPQFRANISVPLGSQQGSMTMSEFGCWDLLAQIFCYALRIYSYSSSQRQPTVIQISFEISSGGQNNDEDDVTDATSKEN
The following text describes a protein:
Function:
Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation.
Sequence:
MSGSEGGVVRSGYLKKLKTSRKKFFVLRAETADASARLEYYDSERKFNNGLPPKRSIPLKNCFNINKRLDTKHKHVIALYTKDDCFCVVLDNDDDLDSWLKALLKLQHGEEVVDGETPKPTFEHVWQVTVLNRGLGNAGLTGNYRLCLTDKTLSLIKRDCEKPTIELNLSNIRSCGNLRDFFFLEIGRSSTLGAGELWMQTEDNNIAQNVHSTVFHAMSTNSSSKDELGPKSRNRSSSATESSKPNMTRKIHIAPKCHIFLPPDVFHTSDTQVIPAGSSTQHPLVSGVASFYQHLIQRGAKASERRHSISAGSLTHCGVISHQRTQSLPLANPAPLSDHSHSRKRPKCMSRERCDSMPSRARTTSEGNHRHLNPYRPASLYGRDISHSPPLGSPVSPPCSTDSAGSSYSLTDETDVCTEMEPSLGRYGHSLTPDEAIAEEDCPDSPPYNNYISMTLHSSDDGYVDMSPRGRHHNSPTASMSSVTSGTPSTDMRFAEYPLEKVTSYLADDDGRPARAYSVGSKPERYKKYTEMGGNSDNLRARALSVGSKKPPARVLPPHGYHHPGTKSSSAPILTNSRGQGSYNSIGPMDDLMEMDFSHNSGYMDMKPVNSGYVEMKPGRKPETSPYVDMSSGSSPAKPSYISPAATTTQTEVYMEMDPRKNHSEYLSMSFTKKLPSPGSPGTPEGYVEMSLGRGHNPSQLTEDYANMSLNNTKKRPNRKKDKNRSEPINIQGGPNPRSLLLARKHSTGTPPTMYLPLVEATPHDSKDSSSSSINTPSSSSTIFPISLNSPSKATPDYIPMDFDKSDYVNYDPKPGVGEFRPINESNDDEGRAYEVLRPSSSESCSTIGGSRPASVSSAHMHYASLDLDEGGNRSPRTVKGSGGEQGEVTLTYAAIDFVKSEGLKHNAVAATNAKVKH
The following text describes a protein:
Function:
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVAPLVSESQSSSIEETDEQQQQYQQLARRRTIQSDLVDIEAESISSALPEGFNYEKKTTATRFLDKTQKYYPVILNIVHGAIWGVLVRKGLMSLTTYSGSFLSGVIWANFAACVVMGLAIDGEVFWIRLLEEKDYPNKGAIPVYTGLTTGFCGTVSSFSSVILEAFNKAADTDIGVRHHYPNGAYGIMQFLAVILAQFGLSIMGFHMGKQFSAVVDNYLPLVTKRIYKVLELTSMILGVVLVVITCILIGVKKQGSWRSWTFSMLFAPFGALLRYYLSKFLNNKVSNFPLGTFTANFLGTLLLAVFTLLARGKLPGGKGHIVTNTIALHVLEGLDDGFCGGLTTVSTFVVELFGLKTLFSYRYGTISILVCFAGVVLILGSYNWSVGLD
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MNNNSFHEYNFNSEYLNKICCNKSYVCYMGQHFSPCALQENSSTWKRHAEESSSENDKGNVWNFQNLSNVQHPYSFSDDGNHSLDPANALERKKACELSTSCLSTMKYPWMRETHAPTHFSSINAMESGDSKYSNGEAVVRNSSSKRARVAFTSSQLLELEKEFHFSAYLCRNRRLEMAELLKLTDRQIKIWFQNRRMKYKKDHKEKSTAKSSYTYLGTENQPLIISRSTTDSPVPLKFQNNYETPSMNW
The following text describes a protein:
Function:
This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression.
Subcellular Localization:
Cytoplasm.
Sequence:
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRHTIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQVSVEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWKILPNHK
The following text describes a protein:
Function:
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MENFLRKTAWLYLSIAVSVFLLDIITKNLAEKLFTTHVEVFPFLEFYLIYNKGVAFGLLSELPDPLRLPLLLITPVIALIITFLYALYSGDRIVAISMGLIGGGALGNLYDRLFLGMVRDFIHLHIGEYYWPAFNIADASISIGIALLILKYFFTKPALKNLVNRTR
The following text describes a protein:
Function:
Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP). Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V.cholerae, and is proposed to play an important role in the transition from persistence in the environment to survival in the host. CdpA functions as a repressor of biofilm formation but has no effect on colonization of the infant mouse small intestine. Does not possess diguanylate cyclase (DGC) activity, due to its inactive degenerate GGDEF domain.
Domain:
The EAL domain is required for c-di-GMP PDE activity, and the degenerate GGDEF domain is required for full PDE activity of the EAL domain. The GG(D/E)EF motif in CdpA is degenerate, having the sequence GVGEW.
Sequence:
MFTVSRLIPDLASANQVLETMDLPHGQSILVQIFSPLSREHVVQLARLIRSRHPQACLLGCSTEEVIFQGEVHHQVTLLQITVFEQTYLSRAVVDYSDDEAADAERLARQLELTSMSRAVVCFSWQMDTLQVARFALRDTQGAPVPVAGGAAKQTPSGRWVLLDEACYQNASVAIALHGEALYVETGGYTEWQPVGRTYRVTAVEGDRVLRLDDEPIEAIYQRNLGAQADLPHDWLISFPLMKGECRHQDLYLPLGLAEEGGLRFNRPLALQDEVRFCFDHPSLTLERVYLTAQQLQAKQCQQVWVFNCALRLNFMHENHELQPLQAVAPTDGCYCWGELLYEHGQQQVMHHSMTFLALREGAVRDDLVPIPLPSYPEGMTSPLFNLIRHAFHDLDAMTDNLAQQIRAQTSLLTASYRRDRRTGLPNRVVLRERLANFAANEHLIALKVTNFNQINEKYGYPVGDKLLRDLSEQFQVFLDQKLAGQSGLYAIGVGEWATVFRAKLDGKSIHSHFYQFVEQLEHVNFEPYGLPNVDYLSISLCAGLVSQGDFAEHSPDELLLRAIEARRYAFNNNHHFCNAARLKVQESVRQERLNWLSRVSRAVVRDDVVVYAQPICQARSHIVASYECLVRIEDEGEIILPGNFLPIITDTHLYTRLSRQMITHTFNMMRHRPEAFSINLSPQDLMSERTLQHLEAAIKSVADPARVGLEVLESEQIKDYGRMIEVCNHFRTLGATIIVDDFGSGYSNIDEIVKLEPQVIKLDGSLIRNIDQDVKQRRIAEQLVKLCQVLNAKTVAEFVHNQTVCRISEDMGVDYLQGYFLGRPSRLG
The following text describes a protein:
Function:
Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGHRVDYFIASKAVDXLLMKYDKDIKKEKEKGKAESGKE
The following text describes a protein:
Function:
May be involved in the export of mRNA from the nucleus to the cytoplasm. In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing. On recruitment to a target transcript, interacts with single stranded RNA, thereby anchoring the complex via the nascent target transcript to chromatin and allowing Panx to recruit silencing effectors to establishing repressive heterochromatin at transposon loci. Does not affect piRNA biogenesis. The interaction with Panx stabilizes the nuclear protein complex. Does not bind nucleoporins, but regulates sbr/Nxf1 binding to nucleoporins and, indirectly, transposon exports.
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus, nucleoplasm. Note=Localized in both the nucleoplasm and the cytoplasm. Not detected at the nuclear rim. Nuclear localization depends on interaction with Panx.
Domain:
The RNA-binding domain is a non-canonical RNP-type domain; The TAP-C domain (also known as UBA domain) mediates the interaction with Panx.
Sequence:
MPNQMRVLDFGDGSVPIQLDYPDSKIFSKCSSYGDRVPGTHWNEITVHHKGRLEYSPNPEQIILDALYQAIDGADFFPVFYQRGKNMDTMLVRNCKAAIDKLFKQRLSINLKGGASIPISIQLGVAQYQRHQITPTFHIARVVTRLMKQLIQRDGVDGLLNLDNFGSHPEFKNLVVSLGNPSILMNVCQVIHNDDNERFRLNGFILSNNRIRDIRPLTLLANVDYALLDLRGNKIKSAERLCRALEQFRARELLLENNPIVKISNFPANIKSLESNFELVDGKPFNMLHKIFSPLDVEIDLEVDGARIDTNNMWKLPEFENSQHWHAFMIPDPSHEFNQEVFFDFFFIRLDPTLSNFYPCYYKYINTEHVFLVRNCFDQIAHLVNNCNLEMTIPTGDRIFRYYLRMNVSTVKQHHVDPEECIQKAVSQCYVAQNRMLNLERFHSRECLKDVMVSLSSPKILTYVLSVASRKFMTTCSEIRLCHNKVLVLDGAHVLGMMGCLRAVDLSHNWVQDLSSIHSLGNLPLKSLVLHGNKLCRNYRLPSEYVRAVKEVFPQLTTLDGVDLQTNPGQSLQKNFLCDTGAYELVGAFLENYLREFENDEFRHNLYKYYSENSIFTLTCNYNVVQNHQTPKILQRLSKYNRHARNLRNKDYSKASDGVFFGCTYIVEILLQLPRVTHDFHSLQTDVMHYNGKGAVIYVAGLLRDEPPSTRNGHGSKTDIGGVLLGFSRQFVVTFDEANLGLGKRARRLKIANERLHITNPSKTAIRNAFSVNFPDPSERQAEEDSLDVKDHKLLLFQEVTGLISTWVTSIVEEADWDFERALKLFIQKNADHEIPDLAFA
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MLSFLDLEVFYLSPPSISAVSSLITTYTMLPGFIFAGLLFIIALLFSNPKFSSWILPHRRRQTPPEETQPNSKESTTGIRGEKEIDMMFATFDKNADGVITAKELFESLRSMGISSTDIEAENMVRSADSNGDGVVDIEEFRKIYNSSVADACSLDQPVSTASEEETEAEREQDMKTAFDVFDVNHDGQISVDELSMVLESIGGRQGCSEEACRDMISKVDLDGDGKVSYEEFKQMMKIKDGEFF
The following text describes a protein:
Function:
Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
Subcellular Localization:
Nucleus.
Sequence:
MKFIQDHTLDEVASALKFDTPECHVSGNIDLYTTKPASSDKKLYKVLDKQLSYHQDALDSFTSISTLGTSFSPPQVLTFDNYYQYGKSLDSSVSKMSNRSPKGVSKVPKQRTYSSSRAGVSVGSLSPLLSSPFGDMSETASRKVFAYLIAILNASDPNHDFSVLQPDDFQREPSASAVISSFNNVLFGLGMPIPPRMWDVLDKSIEMHNCTIFSFTPDATILADEPGALWALSWFFFNKRMKRVACISLNARRHSLSPTLGPKIMRSDVINGDDEEDYDLTYSSDTDMYDEIVGELDLE
The following text describes a protein:
Function:
Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.
Subcellular Localization:
Cytoplasm.
Sequence:
MAESEAETPSTPGEFESKYFEFHGVRLPPFCRGKMEEIANFPVRPSDVWIVTYPKSGTSLLQEVVYLVSQGADPDEIGLMNIDEQLPVLEYPQPGLDIIKELTSPRLIKSHLPYRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDSNVLFLKYEDMHRDLVTMVEQLARFLGVSCDKTQLEALTEHCHQLVDQCCNAEALPVGRGRVGLWKDIFTVSMNEKFDLVYKQKMGKCDLTFDFYL
The following text describes a protein:
Function:
Involved in the transport of copper.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MMHMTFYWGKDVTILFDGWRTATWTGYLLSLVALLLASAFYQYLEAFRIRVKLLAGAKPASIPPPASSDAARAPLLLPSSAAGRWPARLATAGLFGVNSGLGYLLMLAVMSFNGGVFVAVVVGLAAGYLAFRSSDGEDLVVVDNPCACA
The following text describes a protein:
Function:
Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity).
Subcellular Localization:
Postsynaptic cell membrane; Single-pass type I membrane protein.
Domain:
The cytoplasmic domain binds synaptic Ca(2+).
Sequence:
MTFHKTFGYGCIVLICFELLFAGVETSSENDDEYLTQKEIILEKSYHGLIRENETLVEITPLIKVNEEKICNFHILKKPYHEIPFKIELVNNLGILKARRTLNCENRKSYHFEICAIYCDGTPSNTANVHITVIDVNEYAPTFLEPSYVIEVDEGRLYNEILRVEASDKDCTPLFGDVCKYEILNNDEPFSIDNEGSIKNTEPLSHKASHNHILSVVAYDCAMKESAPIMVSIKVRRVCETKFVGMPERIDYTSGSTESLQLFPNARLDLCDISCKNEEDLRIHSSIALKTKHISFGCDRDISNCTSGQKVKDLLPHGAEWTKELSYDEGLEPIFHFDGSTGVVVPATVIDHYDFSSQPFSILTLFRHNSQVEINKHVKEHIVCSADDHKMNRHHMALFVRNCRLIFLLRKNFNEGDLNIFSPAEWRWKIPEVCDNEWHHYVLNVEDSSKVDLFIDGVRFENSIENRHSNPEVIDDWPLHAAHGVNTSLAIGACYQSLENRLKHGFNGDISEVKVSLNSVLTAEDIKCGTTCAEHLLAPKPLQSNNEKSYSDNSQIKENIEMNEIYISAKNKHDIEQFMRKVQYINTKQKPTVGRRNIEVLTTLNCKNESSLRLPPIETYIMVNEPIAPLGIDIDVVSASLETSDLTPPSYSPKIAISGTSNKLVSYQEIKLGVHILEKTCIDSVSKNNGKLEEKNHIDSCSVVVFPSLNPDHEDIKIDGDESLSSSMDIKTNINKDGVEMIGKDTISNYINVLRSLVYSNKKPAYYLNRVFKLSCAQQSSQYKSGEYTLTLTVLHPKQTLFKSTNVLPSSLSKVNFIGNTDNETSFHRNSGSVNGNDNNQPTESKVYSYSLLHTNNVQEPKSHIHSFIHKAEGSHVTMLIILVSVFLAVLLCGVSIARLKNNQKYIEHHQPCPKISDDGLIWDDSALTITINPMQADVTSDASSESENSESEDEEALKDGFTHINQLEWDNSNIFQQ
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MISVGTIFFGIITSSTQINCDIHKEIGFPTLSSYEELQHAKETVSQIKSEKPNVMSRRLLSTPPDCKDRCENCSPCKPILVSIPPLQDPIYKSEGWLCICNNKCYTPNP
The following text describes a protein:
Function:
Produces a 42-residue extracellular sporulation delaying protein (SDP) that collapses the proton motive force (probably both the membrane potential and pH gradient) across the cell membrane, which leads to autolysis; may form a proton channel. Induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, inducing cannibalism to provide a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Addition of SDP to liquid cultures halts growth, leads to increased cell permeability and eventually cell lysis in a significant subset of the population, although some cells survive and resume growth after a lag period. Effects of SDP are irreversible within 10 minutes. Addition of SDP to solid cultures induces killing, it is much more effective than SKF (AC O31422). Has antibiotic action against Gram-positive Firmicutes (L.acidophilus, M.megaterium, P.polymyxa, S.aureus, S.epidermidis) but not Actinobacteria M.luteus or Gram-negative P.aeruginosa or K.pneumoniae. SDP induces expression of the sdpR-sdpI operon. Its maturation is dependent on SdpA and SdpB. Also functions as a ligand, binds to SdpI triggering a signal transduction cascade that protects the cell against the toxic effects of its own SDP.
Subcellular Localization:
Secreted. Note=Produces a secreted protein originating from this gene , secreted by the general secretory pathway.
Sequence:
MKSKLLRLLIVSMVTILVFSLVGLSKESSTSAKENHTFSGEDYFRGLLFGQGEVGKLISNDLDPKLVKEANSTEGKKLVNDVVKFIKKDQPQYMDELKQSIDSKDPKKLIENMTKADQLIQKYAKKNENVKYSSNKVTPSCGLYAVCVAAGYLYVVGVNAVALQTAAAVTTAVWKYVAKYSSSASNNSDLEAAAAKTLKLIHQ