lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain.
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MAFSSRKVNIKKKPPEPSVNGEEQDFIFLSENVLLVVERCMNSMQAGTQMIKLRGSSKGLVRFYYLDEHKSCIRWRPSRKNEKAKISIDSIQEVCEGKQSEIFQRYADGSFDPNCCFSIYYGDHMESLDLVSSSGEEARTWITGLKYLMAGISDEDSLSKRQRTRDQWLKQTFDEADKNGDGCLSINEVLQLMHKLNVNLPRQKVKQMFKEADTDDNQGTLGFDEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDPDDLKRFLEVEQKMMNVRKEYCLDIVGKFEPCPENKNQGVLGIDGFTNYMRSPAGDIFNPDHYQVNQDMTLPLSNYFIASSHNTYLMGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNDYPVILSIENHCSVVQQKKMAQYLIEILGDQLNLSDVVNEDSTKLPSPQSLRGKILVKGKKLPASISDDAEEGDVSDEDSADEIDDDCKLINGDWKASANRKQVENIAKKKLDSLLKESKIRDCEDPNNFTVTTLPPSGKHSQKQELKKKCSSGSKGERALSKTEEEVESGEEPSPNKRHSRSLMGSFSKHKKKGGRIKKCSSLEEGDESLDRQGSLARAPVHYSRINRQKKTMKLSRALSDLVKYTKSVGIHDVETEISCSWQVSSFSETKAHQILQQKPAQFVRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQLVALNYQSEGRMLQLNRAKFNSNGICGYVLKPKCMCQGAFNPNSEDPLPGQMKKQLVLRIISGQQLPKPKDSMLGDRGEIIDPFVEVELIGLPVDCFKEQTRVVDDNGFNPMWEETLVFTVHMPEISLIRFLVWDHDPIGRDFIGQRTLSFSSMMPGYRHVYLEGMEEASIFVHVAINDISGKWTSLCQKSTFRSRDILGAMKVKQAAGLKGLFLRNPKQASLDSHAAGQLHQKHSISSHILRRTASAPTKGQQKNKKGFPEIAIDSKDNSSEGPSEDRETDDSSLPRFEQDPESASPTLPSWDGTNVELNSKSLKGKRFSSRKSKSHVRISRCATFSEPQQRTNKVAFQDSTPNKPGVFARCAMNGSGSIGMATNCIRCMIGSKESPDLECKRYDTNRPIVSDSPVHDQYSVPGEERLELQYYGITEQPRRQQKDLLAFTDNDDLSKNSQSFVIPGKKNGDHKCAGMKSHPRQRWQCLTGCTYGSTINLVPAGSGSVSSNSSSLESLGSPELSKAWHENSRRQAGTLQREMNALFVQKLEEIRSKSPIFFTDPRELLLYRSASSLCSLETIKEEPLFAKEKSPSQAFSQPVDYLKSCESSVCEQPKESLSENSNPAINSENVQRPSKLNVEPTIIKVLAISNEPNPNYGKVNIGKAYNDRNGKILRSVNGKNDSTSLIHSSQIKPGMSLLADVSKKGNEQCPVKSNQAAQSSFPASNQSIANRMMCTNLTYQQTRPTPNMKPSIVPPVQRMQYDRPDSKPSVVHDSKHTPVRRTKSEGYVVSDCSALSLNSTCQSPVAELYSDATVNDRIWSKLELNTHRDSMSSSSSKSSNDTVIDLSLPNLARKSLLDLDISDDNFENIHINNTIRPRSATSLTKEMSLGVMKSKSNPNLVLNNQAIDELSPRPLARSPVEALPPLPRRNTWNRLYVNSLKQTNKKPPHENTPSTNQSMSKSLGDLTSDDISCNFESKYRIISRGFITRSMRAQRRPTSVKGSVKSSDSLTEQLKKLTSFQKENDITSPTEVEPVQCENEDTAFLRRTSSRSQSRVRYIANRAKQAQERQRLQNMCRINGNSIEERGNPEGACAISKGFCMDSLSPTQFTPETLDKFGT
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MTPVLPCSTSNICLIPGTAFSINKNNSLKNGSLSRKSTKYASSSQRLVLPLPGFVKLFPQYHRDCAMVHGSVAHAVSATGTDVAVEEPDSPVVDKDSDGVSEIPADAVETIDSSTKAGSSPAPAQSSRSKGSRKSEMPPVKNEDLVPGATFTGKVRSIQPFGAFVDFGAFTDGLVHVSKLSDSFVKDVGSVVSVGQEVKVRLVEANTETGRISLTMRENDDTSKFQQRNDSPATGSSNRQAARRNTSKPNQRKDEVKSSKFVKGQNLEGTVKNLTRSGAFISLPEGEEGFLPRSEESDDVFAGMMGDSSLQIGQEVSVRVLRITRGQVTLTMKKEDADKRDTELIQGIVHTATNPFMLAFRKNKDIAAFLDEREIATEQPEKPIPSVQIGEKNQTEPLPNIAEVQDQPVSNDEVSSGIPSMVDESVEGDETSLKEVVVGANVASDEKQPETVESSVDSTLQTVEKEAEVTGYKEPESIESSTPQNVDDTVQTLEKKAVADDDKEPESMESSTSQNADDTVQALEKEAEANDKEPESIESSLSQSVDDSVTGSDKVESIENSDASGDTSEAQIISSESRTSEEVVESQVKSIEDEMQIQTPAAETEITSASQLEDKKVEPVPEINGTVGASNGQSGSLSPKESVTTATISPVLVKQLREDTGAGMMDCKKALSETGGDIVKAQEFLRKKGLASAEKKASRATAEGKNWFVHS
The following text describes a protein:
Function:
BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific gene. Controls temporal and spatial specificity in Aspergillus development. Directs the differentiation of phialides and is continuously required for maintenance of their function. Expression of abaA leads to activation of brlA and wetA, cessation of vegetative growth, and accentuated cellular vacuolization. Binds to the sequence 5'-CATTCY-3', where Y is a pyrimidine, making both major- and minor-groove contacts. Multiple abaA binding sites are present in the cis-acting regulatory regions of several developmentally controlled structural genes as well as those of the upstream regulatory gene brlA, the downstream regulatory gene wetA, and abaA itself.
Subcellular Localization:
Nucleus. Note=localizes to the nuclei of phialides and terminal cells of mature conidia (By similarity).
Sequence:
MATDWQPECMVSQNQAALESIGAHSDRALQNTSGNVQAYSDSLAHHDTTGRDDPLQHYTLKYPHPPVPVPSHPLPTATANLYHPQLLSHRYQVKKLRRLQSNGSSYAGSRRGRSYLKSQKYLEYRARPRRDTGKDGEPVWSDELEDAFQQALEANPPMGRRKWSERGKSYGRNELIAEYIYKLTGKRRTRKQVSSHLQVLDSFLKGDPDWERLVREQSDRSTAQTQPVGPRWRTSMDHLPSSHYGTHATSSYPEPMRLMPPYSADLQLPQYSPTSTQQDTNNNTIQGLSFDMWVSAPNKPDRIDDAYHLYTRLQGDQRQPPMPLEDLKNWRVSFPHLSSSLSDVNDPLNCEIILLETNLELMDDFPPMGSRLGIHLELDIANPMSGTAPTVNQMENWTCSTYIYEDGRRTMEAYHNLTKPHTTKVKPPFESSWWAKTFTKLTQDKREAESTGHHHAADERTRRYFHSLTAVQEIRATVPPSLRRLQNHYPGSPAEESKRMAIILWKFRQTRPNEVGTTTWRKLITSPDRALTNSPRPSTAIDLPPLSLDSILLSKPTSNLYQAPPQHHDLLHQNAPSQQSWSLYQPSHDHVNSLYHSAGAFDFLNSITKPEEGLSDKTAPTSVLDPFPNLTQQTTSQTAGINVSSGTPVMLQIPDLSLSSNLGTYGLGHESHYVPSHHNAANLHDHSSTTGLGHYFAPSTQSLDEISHSHAPWSAPNTTISGDTSGGNYHHLPFTTSDHSVTVSRESHQNHSFEGLLPSDDLVGIVGGLSGDPNMNGAGPEHTSSAYAEHTAVEAV
The following text describes a protein:
Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Sequence:
MAHYHGKHSKGMHHLSAHNHDAHGWVEGITSLKADDRAVELLADEPERLPGAMTGQASATAAAAAAAARAATASAGTPAKGEKPTSSDGTGGDAAAAPSPASPGGAGGAAAPGVVSLTRPEDFESALQHALEVMTAEIEAVGEMMLEVGAPMGWGPVGLTAEQLGTCLDRIRTAVEPLQVDATVVCQRTTQLPTATGPVDCVTADVLLRRRPGPKGPQEVRVAIIGNVDSGKSTMVGVLTRSMLDDGRGLARSKVFKHHHEEATGRTSSIGQHTLCLDSKGGILNDSLFRTATCHEYIAKASKVLTLVDLAGHERYFRTTAYGLTGHLPDYACLIVGANMGVVGMCKEHLGVALALKVPVFFVVTKVDIAPEHILKQTVQNLASILKKPGVKKKPFLVRNQEDVLLCARNMNTDSLAPIFLTSAVTGKGLDLVRLFYNLLPQRQRWVDKQRELAEFVIDETFGVPGVGTVVAGTVKRGIITPNTMLLLGPDIGDGSFKAAAIKSIHYKRLPVNTVVAGQTAALALKKTKRSQVRKGMVLVDERLKPAASWEFDADIAILTHSTTIQPRYQAVIHCEIIRQAARVVAMDRERLRSGDRACVRFRFIQRPEYVTSGTRFVFREGRTKGIGIVVGTEHQPADRINTPRGANGEPLDPHRPDELEADRERERALAEVGTGTGAGTSSSTGGVVPGAAGAGGDVAAPLSPASAVAVRG
The following text describes a protein:
Function:
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
METSPLILLAAGGTGGHLFPAEALGVELIRRGFRVRLVTDERALRYSGLFSKDMIDVVSSETARGRNPFQVAYAGLTLAAGTLSAYSLIKRLKPVAVVGFGGYPTLPPLVAAKFAGVPGIIHDANAVLGRANRFLSSRVRAIATSLPGVLDRDPALSGKTTTVGTPMRPAVLAAAAVPYAAPEANGPLRLLVVGGSQGARIMADIVPGAIERLEPALWGRLILTQQVRDEDMNRVRAVYDKLKIKAELAPFFTDLPARLASNHLVVSRSGAGTVAELAAIGRPSILVPLPGSIDQDQFANAGVLAKVDGAIRIPQTEFTSDRLASEISALAAEPARLTAMAAAAKGAGRLDAAERLADLVVKVAGL
The following text describes a protein:
Function:
Acts as a negative regulator of cell wall and septum deposition.
Subcellular Localization:
Cytoplasm.
Sequence:
MFVGSPSAIEKPLSLSSKTKVGDETEFTEDALRGSSLVPTGILNGDDECHALHMSPQAIHSQAGKAESDGLPTYASVEKSTTPIGRLLSNLNGGLASAPPKVGFGFPRYYALRIEDLPRDLTPREFLCTFLFATNVVSVELNPVSVDNEVAHGLAVFSSRDAAASARDTLLSSDVYSACSMIILDNYRKGSQTNLSDETEGSESSVSFNRLSRNHSPTRPLLGNRDLFRRSSNHVSASMPTANHSESAYRHSKTPLGDSTFQAPNNGGSLHSDRLWSSFPVSYPLTLANVLAKDEVGSPTWSPTPSKSSTNLRQDGVPPILRFNSLSINTNVARNYLSSEKGYSAHTQNSSAQSPHPRVFSANSAFSTTSPPPLTPSTSRDYPFSASTISPSTPFSAYSSSHGIHQRIPASTPTNTNPADQNPPCNTIYVGNLPPSTSEEELKVLFSTQVGYKRLCFRTKGNGPMCFVEFENIPYAMEALKNLQGVCLSSSIKGGIRLSFSKNPLGVRSSSSSHNNHNGNVRNLHSGSMNNYNTDSLLNHTGGHNEVHASPSWGNNLMYGK
The following text describes a protein:
Function:
Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Plays a role in outer and inner axonemal dynein arm assembly.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, cilium axoneme. Note=Localizes predominantly in the cytoplasm and weakly in cilia. Transported within cilia in an intraflagellar transport (IFT)-dependent manner. Accumulates at the ciliary tips during ciliogenesis.
Sequence:
MQIESDNQVTNQSYSFFRQENTILDDKKFMEILQKWGLQHSIKVSTFLFDIKFDHLNPNQFLLDLFNSKDVRGSLHYVSFKQNVLLSQIKFQPLTCKSIKLDLFDKLTEDKIVVKGHIKQCFEEQFENIQIADELRKALVLEDSEQYCVFNEADRQELLFKLFQILVLGGQLCQYEDEIQAYLDWTKYLYKNTVNARKYADKDEIYIDSYAYDIRKLENSYSSDHPQNVMYVVVNPSLRIVNIIENQWLKVW
The following text describes a protein:
Function:
Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane-associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. RcsC also has phosphatase activity. The system controls expression of genes involved in colanic acid capsule synthesis, biofilm formation and cell division.
Miscellaneous:
MISCELLANEOUS: There is a close linkage between the Rcs and PhoQ/P signaling systems, and both signaling systems respond to certain external divalent cations (zinc and magnesium).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKYLASFRTTLKASRYMFRALALVLWLLIAFSSVFYIVNALHQRESEIRQEFNLSSDQAQRFIQRTSDVMKELKYIAENRLSAENGVLSPRGRETQADVPAFEPLFADSDCSAMSNTWRGSLESLAWFMRYWRDNFSAAYDLNRVFLIGSDNLCMANFGLRDMPVERDTALKALHERINKYRNAPQDDSGSNLYWISEGPRPGVGYFYALTPVYLANRLQALLGVEQTIRMENFFLPGTLPMGVTILDENGHTLISLTGPESKIKGDPRWMQERSWFGYTEGFRELVLKKNLPPSSLSIVYSVPVDKVLERIRMLILNAILLNVLAGAALFTLARMYERRIFIPAESDALRLEEHEQFNRKIVASAPVGICILRTADGVNILSNELAHTYLNMLTHEDRQRLTQIICGQQVNFVDVLTSNNTNLQISFVHSRYRNENVAICVLVDVSSRVKMEESLQEMAQAAEQASQSKSMFLATVSHELRTPLYGIIGNLDLLQTKELPKGVDRLVTAMNNSSSLLLKIISDILDFSKIESEQLKIEPREFSPREVMNHITANYLPLVVRKQLGLYCFIEPDVPVALNGDPMRLQQVISNLLSNAIKFTDTGCIVLHVRADGDYLSIRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLISMMDGDISVDSEPGMGSQFTVRIPLYGAQYPQKKGVEGLSGKRCWLAVRNASLCQFLETSLQRSGIVVTTYEGQEPTPEDVLITDEVVSKKWQGRAVVTFCRRHIGIPLEKAPGEWVHSVAAPHELPALLARIYLIEMESDDPANALPSTDKAVSDNDDMMILVVDDHPINRRLLADQLGSLGYQCKTANDGVDALNVLSKNHIDIVLSDVNMPNMDGYRLTQRIRQLGLTLPVIGVTANALAEEKQRCLESGMDSCLSKPVTLDVIKQTLTLYAERVRKSRDS
The following text describes a protein:
Function:
Required for posterior mesoderm formation during embryogenesis. Acts indirectly to suppress head formation by altering mesodermal patterning. Also involved in the establishment of left-right axis asymmetry, acting upstream of nodal/nr-1. Can exert long-range effects in the embryo (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MLSLACFFSFLLMVKSSPLTFQERMLLKALGLNTRPNPIAPGPVPKSLRDIFEKGINKDNPCMMEGFGVPGNIVRSYRDQGPVAAMEEPQESLCLKKFLFFDLSAVENKEQLTLGQLEIKFKHNSYYGQQFHLRLYRTLQLSLKGMRESKMNRKLLVSQSFRLLHKSLYFNLTKVAKDWKTPEKNMGLLLEIYASSKLAGDNRSFAVCEPIQSFIYTSLLTVSLDPSSCKTPRAKRSTHSSPPTPSNICKKRRLYIDFKDVGWQNWVIAPRGYMANYCYGECPYPLTEMLRGTNHAVLQTLVHSVEPESTPLPCCAPTKLSPISMLYYDNNDNVVLRHYEDMVVDECGCK
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.
Sequence:
MATSSVGALLQTAHIGHHLSSEQSSEQGSIKSFRNVGAYEHATRPFSFGSKEALRIRNLLVQSLSKASSRAASAPYGPRQSRRQGQAPEQVKCAARKRFDSSELGERSLDTEADVVIIGAGIIGLSIAHTLLRDTPFSVAVIDRAQPCAGATGAGQGYIWLGNRQPGTPAWDFAKWSKSLWEDFADELALEPSQTTAPLGWNKNGSLLVAGNGKEAAALKTQVDLLQSAGLGAELWDAQRTRAVEPALLIEDDGGAAFLPDDAQLDAELAVAALRARCQGHVAAGRYTELFYEPVQTFLWSSDGSAVQGVRTSKRTVRANRSVILATGAWTSDVLAADSDGRTELGSAFAAISPRKGHLLIVEGPGLPRLKHALMECEYSANAARAATAAERSSWPPQSPNPPSANANGTPPLNGDRNSSPESSGNGRVAESSTEERSYRSREAGVSSAGDTSARMMSAERPVIPPGPYKPSVPWEFPLSAKTLNRDTENHETLNPPSSVSVAMTATTDPFGRLLIGSSREFSGFDTGIRDETIVAIIRRAAKFLPALEGLVRGADVRNSVRTGLRPYAANGRPSIGVVPGVDGLLVAAGHEGSGLCLAPGTAAIVRDLLLGVTPEIDCSHFAPQTVSPLAGTNLIK
The following text describes a protein:
Function:
Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A. KSH is also able to use 4-androstene-3,17-dione (AD), 3-oxo-23,24-bisnorcholesta-4-en-22-oate (4-BNC), 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oate (1,4-BNC), 3-oxo-23,24-bisnorcholesta-4-en-22-oyl-coenzyme A thioester (4-BNC-CoA) and 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oyl-coenzyme A thioester (1,4-BNC-CoA) as substrates.
Sequence:
MSTDTSGVGVREIDAGALPTRYARGWHCLGVAKDYLEGKPHGVEAFGTKLVVFADSHGDLKVLDGYCRHMGGDLSEGTVKGDEVACPFHDWRWGGDGRCKLVPYARRTPRMARTRSWTTDVRSGLLFVWHDHEGNPPDPAVRIPEIPEAASDEWTDWRWNRILIEGSNCRDIIDNVTDMAHFFYIHFGLPTYFKNVFEGHIASQYLHNVGRPDVDDLGTSYGEAHLDSEASYFGPSFMINWLHNRYGNYKSESILINCHYPVTQNSFVLQWGVIVEKPKGMSEEMTDKLSRVFTEGVSKGFLQDVEIWKHKTRIDNPLLVEEDGAVYQLRRWYEQFYVDVADIKPEMVERFEIEVDTKRANEFWNAEVEKNLKSREVSDDVPAEQH
The following text describes a protein:
Function:
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MNNNSNNNNNNNIDQKNETTNEITNNTSNNNNIINNVNQNSTSITTSPILSPNNNINDNSMMDGKRLCASSKKVCSKRPMETYRFCIKHILEEPSAPFKQCEFISLKSQKQCTNPVSIKEKDPRFCVSHKHIIESTKKRVLESVVSSITSPSSSSPLPNASLIGSNSNITSPLQNLTTLNAFTGNNNNNTTTTTTTTTTNSTPSLNFDQQINIDIDNINGGDEPNLSLSASSFNFNIISNNDEEPKKKIMKILDRHGISQGRFYQDFKQNLKQLKQKHKQKQQLQNQKMFEQSQQQDQQQKPVQQPIQQQQQQDQLQIQEERQVSQQDEILEKQQQQQQQQQQQQQQQQQQQQQQQQQKKQQQELQIENNKENENINESNYFGEEFIEKDLEIELFKAMDDGHLSELCEDFDSDFYFASSSVLTDEELIQRRKIYISKLILLYKKQYNRFKERLRIIRRHYISTSLSLNQQNDSNKMEIDNNNDNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKLNKRKEEGNLCLSVNCKVKPMLLSKYCYSHILQDKDQKLFHECTYQLSANKKCGYPILKVQIPTLCREHLDIYETNNEIIKSLPKKQKQFIKQRIDIEKHNAPSTLVPVTQPINQNNQNNNNNNTNNSSKEESKDNNNNNNNKEILKDSDNTMIS
The following text describes a protein:
Function:
Involved in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I).
Sequence:
MLQRVSRRFPSLRRCGLRTASTVPTNQAQPGEVEEEVSATVKRIRSELAADKQKLKWRTPIGDRPEDWNSKLKLFSNAEQTSDFIVMMQKPIDLSPRNIRQWWENREERIERHMQQFVPERHKILGAELAAAHFILYRGGAVKFINDTHWRRASKDGEFKLPNKFDPRYKVEALRCDNMELYYEGLENLRCLDSLKFLSFHNVKSFDDWCLDRISGGGFPNLEVLDLSCTQITSNGLACLYRFPKLKLLILNDPKETLELELSTVMLEEAMPALKIVGADAIHS
The following text describes a protein:
Function:
Penicillin-binding protein with an unknown catalytic activity. Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins, thereby interrupting normal cell wall synthesis.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLIQESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGMSEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASHTIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGNPLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVLGIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYGEPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLYHETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGEKRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQDLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTNSVFYDIVKKVHEIEINQK
The following text describes a protein:
Function:
Catalyzes the conversion of methylthioalkyl glucosinolates of any chain length into methylsulfinylalkyl glucosinolates.
Sequence:
MAAGDGEPEPAVQQRPQLQSKNVCVVGGGMAGLAAARELRREGHAVTVMEQSGDVGGQWLYDPAPTRGLVPSASSAYASLRLRTPREAMGFSDFQLLPRDGAGRDPRRFPGHREVHCYLRDFCAAFGLMDAVRLNTRVVRVAPTSTATRQWAVRSVRRLGGPEDGARAEEEEEEAVFDAVVVATGQYSHPVLPSGIEGAGEWRRRQLHSHLYRTPEPFRGEAVVVVGCGDSGTDIALDLRRVARVVHLAAGSEASTPAVSRMVANHGDVLRLHPRARRLHADGRVSFDDGSSVVADTVIYCTGYGYSFPFLDTGGAVAVGDGGCVVGPLFEHVFPPSLAPSLSFVGVPRKVLVPWFVEAQARWVAQALSGRRALPPEAEMVRAVEEHLRAREAAGVPRKHAHHHINGIDKMIEFMEEHGGLTPMEEWKEELLLSSVASMCDDLETFRDRADDGESVRKGLQGWRGGLAAQAQHEAMDAAAEAEADGLAMDD
The following text describes a protein:
Function:
Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.
Subcellular Localization:
Cell projection, podosome. Cytoplasm.
Sequence:
MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKKKSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSGEPLPPKLAPGSPAHVGVLELDGVSRQQNSVGREKELLNNQRDGRLEGRPVPDGDIRQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPNEVAQLRLGDAAAMENSSGSEASGPSRPLPDAPHSAGDSGTPWAKDWKGGKEVLRKASSDTSSCAGYEEISDPDLEEKPSLPPRKESIIKSEEELQERQRMEQFRGSSPKPPGMILPMIPAKHALPARDGRKAEPKPEKSKLFQLKNETGLECGHRVLAKEVKKPSLRPISKSKAGLPEEKPEAVPQNLFLKSKPQVRPKPAPSPRTEPPQGEDQVDICNLRSKLRPAKSQEKASVDGESSHQAGGGQDGAFSRGFPPGEGPGRAQDRTSKQEGPSPKEAPCRAPPRPAKTTDPVPKATPVPLQEASLQRPVVPPRRPPPPKKTSSSSRPLPEVRGPLPEVRGPLPEVRGPLPEVRGPQRESSEGKAAPAPGRALLVPPKAKPFLSNSSGGQDDMRGKGGLGPRMMGKTGENKEKVAAGPFPSTDGPKDLYVAVANFEGDQDTSSFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKKP
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MIVDSISSSTASTSSSSPTRGTPIRKSLQCAVCGDVALGKHYGVNACNGCKGFFRRSIWKNRTYACRHGGKCLVAKEQRNACRSCRLTRCLDVGMNPRAVQGDTVEDPEWDEEAMPETLSISTQTDALKVKKKSHTSLFTLDIKKEQIIDNLRAIYARTDPEEFWKLTYPGTYDFRYAFHNTKVVSPRTPLTPTAERIATLNDVVADFRRAFVLFVDILKSIDQLRDVQEDDKMKIAKSRFAAFYWWLCSTWSAKAGCNGVCYSNGSYHPASISDMPKSEGKHGVRIDYSGVSQKSLENLVEPLRRMELSDEERIVGAVMVILADPVPNVSTKTEKILAEARDFYLELLGYCIKLPEEQQGIRVSTMVLLLASIMELVHLTTDNIQLSDVLHVIDLGDWSQELRDHRYRRQF
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MADEFILETEGLTKEFAGFFAVRDVALKVRRGSIHALIGPNGAGKTTCFNLLTKFLRPSAGKILYKGQDITAMAPADVARMGLVRSFQISAVFPHMTALENVRVALQRQHGSSFDFWRSKSVLNRFNDRARDLLNDVGLSEFANTPAVEMPYGRKRALEIATTLALDPEMMLLDEPMAGMGHEDIDKIAALIKRISAKYTILMVEHNLSVVANLSDIITVLTRGQVLAQGHYSELTKDERVKEAYLGAGHA
The following text describes a protein:
Function:
Involved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex.
Subcellular Localization:
Cytoplasm. Note=Interaction with either DPA or DPB are unable to induce a nuclear localization.
Domain:
The N-terminal region (1-100) is important for both SKP2A binding and ubiquitin-mediated degradation.
Sequence:
MAATSNSGEDPTLSYHHRSPFRFELLQSISSSDPRYSSLTPSSTNRPFSVSQSLPNSQLSPLISPHWDDSYSQITQKVQKSRKNHRIQLGSIANMSGGESIDIAKVIVKQESSPQNVKRVYNKSKGGTKLLKAGKRMANGEVQNGGLNGASINCRYDSSLGLLTKKFVKLIQEAEDGTLDLNYCAVVLEVQKRRIYDITNVLEGIGLIEKTTKNHIRWKGADNLGQKDLGDQISRLKSEVESMQSEESRLDDLIRERQEALRSLEEDDYCRRYMFMTEEDITSLPRFQNQTLLAIKAPTASYIEVPDPDEMSFPQQYRMVIRSRMGPIDVYLLSKYKGDSAETSDKLGNESDQKAPVGVDTPSLKIVTSDTDLKADYWFESDAEVSLTDLWSNFNS
The following text describes a protein:
Function:
Transcription repressor subunit of the SEU-LUG transcriptional corepressor of the C class floral homeotic gene AGAMOUS during the early stages of floral meristem development. Is part of the A class cadastral complex that define the boundaries between the A and C class homeotic genes expression and function. Interacts together with APETALA2 and SEUSS to repress AGAMOUS expression. Also plays a role in ovule and pollen development. Implicated in embryo and floral development. Involved in post-synthesis cell wall modifications necessary for mucilage extrusion from seeds upon imbibition, probably by promoting the expression of genes required for mucilage maturation. Involved in vegetative leaf morphogenesis at later stages of leaf development by restricting cell expansion during leaf growth. Regulates the maintenance on leaf polarity and meristem activity as well as the initiation of embryonic shoot apical meristem (SAM) development.
Subcellular Localization:
Nucleus.
Sequence:
MSQTNWEADKMLDVYIHDYLVKRDLKATAQAFQAEGKVSSDPVAIDAPGGFLFEWWSVFWDIFIARTNEKHSEVAASYIETQMIKAREQQLQQSQHPQVSQQQQQQQQQQIQMQQLLLQRAQQQQQQQQQQHHHHQQQQQQQQQQQQQQQQQQQQHQNQPPSQQQQQQSTPQHQQQPTPQQQPQRRDGSHLANGSANGLVGNNSEPVMRQNPGSGSSLASKAYEERVKMPTQRESLDEAAMKRFGDNVGQLLDPSHASILKSAAASGQPAGQVLHSTSGGMSPQVQTRNQQLPGSAVDIKSEINPVLTPRTAVPEGSLIGIPGSNQGSNNLTLKGWPLTGFDQLRSGLLQQQKPFMQSQSFHQLNMLTPQHQQQLMLAQQNLNSQSVSEENRRLKMLLNNRSMTLGKDGLGSSVGDVLPNVGSSLQPGGSLLPRGDTDMLLKLKMALLQQQQQNQQQGGGNPPQPQPQPQPLNQLALTNPQPQSSNHSIHQQEKLGGGGSITMDGSISNSFRGNEQVLKNQSGRKRKQPVSSSGPANSSGTANTAGPSPSSAPSTPSTHTPGDVISMPNLPHSGGSSKSMMMFGTEGTGTLTSPSNQLADMDRFVEDGSLDDNVESFLSQEDGDQRDAVTRCMDVSKGFTFTEVNSVRASTTKVTCCHFSSDGKMLASAGHDKKAVLWYTDTMKPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRVWDADNKGYSLRTFMGHSSMVTSLDFHPIKDDLICSCDNDNEIRYWSINNGSCTRVYKGGSTQIRFQPRVGKYLAASSANLVNVLDVETQAIRHSLQGHANPINSVCWDPSGDFLASVSEDMVKVWTLGTGSEGECVHELSCNGNKFQSCVFHPAYPSLLVIGCYQSLELWNMSENKTMTLPAHEGLITSLAVSTATGLVASASHDKLVKLWK
The following text describes a protein:
Function:
Involved in telomere capping.
Miscellaneous:
MISCELLANEOUS: Present with 2160 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, COPI-coated vesicle.
Sequence:
MSENKNSEAEDVFEFLDSLPEAKNGGKMVNTDVKGSQEGVKGGSNSVAGKTGNDGKKGDDDIFEFLEELEKSNLSLTDKKGVEKKAPSESVNNKAQDEKVEESKENKNSEQDAHGKEKEPQQQEKEEEEEEEEEEEEEEEETPLHDPIASISNWWSSSGSAKVSSIWNKTAEQASQIKNRLAQEQLDLTSKINTSTITEIARNLQKIVVGETEEVLRIHLVHDLVNYPSLQYNIESKFDQVLSSQVEGGIRIFVDEWGHPNNNGITPVEKKPSVADGELGNSKKKLQFNLFDGKVTDGEKLAFANLENAVKLFNTAHEEYQKQQKEADATPDDDRSSISSNSNKISDLFISILPIAIPQKQKDADGDFQVTDSNTPGNFNFTLVLKDITNDITTITRSQGFPVKWVNWLEGSVEKTGSTASEERNKSYDQKKQKESEDEDEDDEIIDPSEWVKEWIEDGLSLSFGVMAQNYVIDRMGL
The following text describes a protein:
Function:
Involved in the degradation of steroids having an A:B ring fusion in a trans configuration. Catalyzes the elimination of hydrogens located at positions 4 and 5 and the introduction of double bonds into ring A.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MSNVKKHVSTINPVGEVLDVGSADEVQWSDASDVVVVGWGGAGASAAIEAREQGAEVLVIERFSGGGASVLSGGVVYAGAVPATRRKPASRFTEAMTAYLKHEVNGVVSDETLARFSRDSVTNLNWLEKQGATFASTMPGYKTSYPADGMYLYYSGNEVVPAYGNPQLLKKPPPRGHRVVAKGQSGAMFFAALQKSTLAHGARTLTQARVQRLVREKDSGRVLGVEVMVLPEGDPRTERHKKLDELVAKSACIRRRVPRRVAVNVRRSRARSARSATSVPAKVWCCPLAAISSIRNCWSMRRYKPGWLTGAAGCDGSGLRLGQSVGGIAQDLNNISAWRFITPPSVWPKGLVVNIQGERFCNEQVYGAKLGYEMMEKQGGQAWLIIDSNVRRQAAWQCLFGGLWAFQSMPALALMYKVAIKGKSVDDLAKKLRMDAAVLQLQFDRANAPARGEIEDPLGKSQDMRHEFKGGSLFAIDISISQKMFPLAVLSLGGLKVNEDNGAVIDGAGYDIPGLYAAGVPPLVWLPRVT
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRVDVDKYLFIGREKSEFFSACREIGAVEFLSKSKLKDSEKVRKLSEGLKVLNLLTKSCSPADLVSTKSGYLVTEQLLQEIFDLNQEITTLTESLKALGKEIVRVKPLGDFSSEEIRELTLKTGLAVRFLYKRHIEGAPLEVEEENVFYLATAYNYDYYAVIGIVSLSKDIFTEIEAPRSVNELREEEGHLQALLRKKKARVCELYAYREDLLEALCEQCNEQSLQHAEVSAEDLFDDKVFSALGWVIVDRLDEVKKLCDSLGIYLERVQPDPDEVIPTYLENHGLGALGESLVNIYDTPASTDKDPSLWVFFSFFVFFSMIINDAGYGLVFLATSLFLSFKARKQIKRSIALKRFLQMFMILGLGCVCWGGATTSFFGVSVSYTSPFREYSLTHFLALKKAEYYLKERPKGYKELVHDYPILKEKKTPKEFLLAQSTSSGDSVYKAVVYDKFIDNILMEIALLVGVVHLSLGMLRYCRQRYSSIGWVIFMCGAYMYLPIYLQAVSLIHYALHIPYELGGLVGYYVAFIGLGVAILGGVIQRGLRGLDEITAVIQVFSDVLSYLRLYALSLAGAMVGNTVMVMSERFSPAVGILIIIFGHTVNIALSIMGGVIHGLRLNFIEWYHYSFDGGGKLLHPLKKVICQKSQNL