lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable phosphatase.
Sequence:
MARGEERGRTRGRGGERRGEGWSLSLFLSRISHSTWLVANECSPSLLPLLLSPFPSIHPSMRRKRGSRDKVPVGSISKKVPRSSLQSPSVSLPDQDESLIWQVNEDSNDSTTPDHSSSPIDYDSGLSLSSSVALPCLSLSQPTLAATHTFFLSLSIPYSLKTCHFVPIAITALIYSIGRKYWMALYNGGHTNKHAGHFISKPHCRIYMMANVPPLTDEMRYRCPALPLRTRSTPEFSLVLDLDETLVHCSLTPLQDAALIFPVHFQNTTYQVYVRLRPHLHEFLEKMAQCYELILFTASKRIYADKLMNLLDPGKKFVRYRLFREHCVNVFGNYIKDLSILGRDLSKTIIIDNSPQSFSYQIDNGIPIESWFHERQDTELRKLIPFLEDVSKQGCTDVRCILRERYRIRDQLMQFTEENPQNGFPSPPPSPYCPDNTAIAYTVSALIHLLTMVFKATILVGGAQKGTRFRPLSLQLPKPLFPIAGVPLVEHHIDQLAQLPALSEIILLGFYPAEEFADFCERCQQQYRIPIRYVQEKGPQGTAGGMARLKEELLSGEPEGIFVMNADVCGDLPVDEMVEQLNTQKEAECILLTTEATREQSTNFGCVAIGGNNRVLHYVDKPTTFISVNISCGVYLMRPRIVKSLEACESGSLWFETDIFPHMTHKGTLYAHNTKRWWSQTKTAAAVLYANRAYLRLYRTRYAARLRVAGAQIVGDVFIDPSAEVDPTAKIGPNVSIGPNAKIGKGVRIKESIILADTIVHKRACIMHSVIGWRSVIGEWSHVEGVPLAPNPNVPFAKMENRPLFLKDGRLTPSVTILGSDVTVAPETILLNVVVLPYKELTQSHTNQIIL
The following text describes a protein:
Function:
Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini.
Subcellular Localization:
Secreted.
Sequence:
MGALRWLSLAAAASSALALTPEQLISAPRRSEAIPNPSGNIAVFSSSQYSFDTHESSSAWNLLDLRSGKITPLTNDSNVSEIVWLNDSTLLYINGTNAQIPGGSELWVSGLSNFPSGYKAASLPASFSGLKAVTTKSGDIKFVAYAQSYRNGTAYNEELAETYLSSARIYDSIYVRHWDTYLTTTFNAVFSGTLKKTQHARYASAGSLKNLVAPIPNAESPYPPFGGSSDYDISADGKWVAYKSKAPDVPQANHTTAYIYLVPHDGSETPVPINGPGSAPEGIEGDSNNPVFSPDSKSLAYLQMKDPTYESDRRVIYIYDLASKKITPLATEWDRSPDSLKWTDKSTIVAGSEDEGSGNLFLIPVKKATGDFIPEKLTNGKYASAFYLASGNTLVVTGSTLYSSWYVDLVSLNPKRGTIKNLVSAHEIDPELSGLGPEDISDIWFAGNWTDIHAWVIYPEGFDKSKTYPLAFLIHGGPQGAWYNSWSSRWNPKVFADQGYVVVAPNPTGSTGYGDELTDAIQNNWGGAPYEDLVKAWEYVRDNLDYVDTDRGVAAGASYGGFMVNWIQGSDLGREFKALVTHDGTFVADAKISTEELWFMEREFNGTFWDVRDNYRRFDPSAPERILRFATPHLIIHNDLDYRLPVAEGLSLFNVLQERGVPSRFLNFPDENHWVTSPENSLVWHQQVLGWLNKYSGIAEDNEDAVTLEDTVVPVVNINPPA
The following text describes a protein:
Function:
Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM
The following text describes a protein:
Function:
Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.
Sequence:
MFIHGFQEEVGNLWQETLRHPFVRSLADGTLEKEAFYYYLLQDDYYLSHFEKVIEKSVEQAGTAELAAEMREVQVRLQQSELLMREQFYPRVGLTERDFSERKPAPTAYHYTSHLHRMVDFGSFGVTIAALLPCYALYADIGKMYEGARSSEPFYQELLDSYVDENYQKVVLQQKRLVEQAASMADARELALMKQAFQISVEMEWAFFDMAYKKQNWRGSVNYV
The following text describes a protein:
Function:
Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes mainly in the cytoplasm.
Sequence:
MIGSPDVVAFTKEDDFGDSFSDPLSLPDEFSVPLFTHAANANPWTKTSYAKFSKDFILISEFSEQVGPQPLLTIPSDPKVCGTFDLNYFSLRIMSVDYQASFVGHPPGSNYPKLNFVEDSKVVLGDSKEGAFAYVHHLTLYDLEARGFVRPFCMAYISADERKIMQQFQELSSEFSKASECLKSGNRKAFANELEKKLKDLEYTRSVLHKETELQKMNNGCYSTQAIEKANELANVEKSIYEHKDLLRQITSYPSRRKRDVDFVQCEAEKPPVMDETLKDTNPSDSAENTVETESRKSSYTPQLIKAKSAKCFDKRLKTLEELCDTSFFLQTLEQLNAVEKSFRGDLCFIYTSQIDRALVSKQRVTSFLFEAEHDWEDGGASKNFSIPSNNPTIPILNFSGEPLSLDSYTTCIDVDHLKPGVESGEGPPESSTSDITQETSEAADTETKGSFSSDKSIEALGSVSPSSLQTNFFDGLERRSKISIPSYSDNASSSIAVPHRRSDGNLVQMDAACCIGQDGFIFEDPLPELAQECCGDTVVNQEPLSLLHGDPALQMDYILEESPNMGLTFSELNTSVLSEEVAKINIEDVFDRTSFMSISTSSDRAVSPFTYGSALTVKQKKKAGHSALRFIRQYPFAQQAISCLLSGRTLVILGVDEGTVRKLVNALFIFVPNLGKYGETVQPWLSTPFQLTDLQRWKLIGLQRAVSPAGSSILHSLNRYSRYISILDCDNKTLRCPPYKGTLISHLADHRTQIKRGSTYFLHIQGMLTQLTAKAFLYTFCHHIHLPMDINDQGSVTSRRTNFLLQLGYTVEESKIIQYLSELIKQHYIHGSAKVGNPSFSFNYTTSYLYKI
The following text describes a protein:
Function:
Transcription regulator that binds to an inverted DNA repeat with the consensus sequence 5'-TAC[GT]AC-NNNNN-GT[AC]GTA-3' and regulates genes involved in antibiotic transport, detoxification and cell wall function. Also regulates its own transcription. Binds DNA as a dimer.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKLTRLGDLERAVMDHLWSRTEPQTVRQVHEALSARRDLAYTTVMTVLQRLAKKNLVLQIRDDRAHRYAPVHGRDELVAGLMVDALAQAEDSGSRQAALVHFVERVGADEADALRRALAELEAGHGNRPPAGAATET
The following text describes a protein:
Function:
May have antimicrobial activity.
Subcellular Localization:
Secreted.
Sequence:
MMFAYIVAVVSALALTSAYPTGAPSSTCVSMRPGHLADPQPLPAPYTISTPVNTMKAGDSIEVTISGNTPDDFFRGILLQARQGDNIVGKWTVKDDFSKLLDCGEPDNAVTHANSVDKTTVSYIWTAPEDFVGDVVFLVTIVKVYETFWVAIPSAPVTVLSHK
The following text describes a protein:
Function:
May play a role in the downstream signal transduction pathways involving GRB2 and GRB7.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MAVLFLLLFLCGTPQAADNMQAIYVALGEAVELPCPSPPTLHGDEHLSWFCSPAAGSFTTLVAQVQVGRPAPDPGKPGRESRLRLLGNYSLWLEGSKEEDAGRYWCAVLGQHHNYQNWRVYDVLVLKGSQLSARAADGSPCNVLLCSVVPSRRMDSVTWQEGKGPVRGRVQSFWGSEAALLLVCPGEGLSEPRSRRPRIIRCLMTHNKGVSFSLAASIDASPALCAPSTGWDMPWILMLLLTMGQGVVILALSIVLWRQRVRGAPGRDASIPQFKPEIQVYENIHLARLGPPAHKPR
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of both cell wall (peptidoglycan) amino sugars, N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), at the 6-hydroxyl group. Neither the non-N-acetylated forms of the cell wall sugars, i.e., glucosamine and/or muramic acid, nor epimeric hexoses or 1,6-anhydro-MurNAc are substrates for the enzyme. May have a role in the rescue of the murein sugars GlcNAc and MurNAc released from muropeptides during cell wall turnover in C.acetobutylicum.
Subcellular Localization:
Cytoplasm.
Sequence:
MKYVIGIDGGGSKTHMKISTLDYKVLLEVFKGPSNINSSTKEEVKRVLQELIMEGLGKLGQSLEECSAICIGTAGADRTEDKSIIEDMIRSLGYMGKIIVVNDAEIALAGGIEKREGIIVISGTGSICYGRNKEGRSARSGGWGHIIGDEGSGYDIGIKAIKAALKSFDKRGEKTILEGDILDFLKLKSHEDLINYIYRSGVTKKEIASLTRVVNSAYIKGDLVSKRILKEAARELFLSVKAVVEVLSMQNKKVVLTTAGGVINNINYLYDEFRKFLNLNYPKVKIISMKNDSAFGAVIIARSECD
The following text describes a protein:
Function:
DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.
Sequence:
MQQLDGTLERITFQSESDGYTVAQLRPLGKRHTVTIVGNLPGVQPGEQLSLEGEWRDHPTHGRQFHVQRYRSRLPATVDGIRRYLGSGLIKGVGPVLAKRITETFGKYTLEVLDREPERLSEVPGLGRKKAVLIAEAWRAQQRIKDLMLLLQDLGLPTGVAVRIYRHYGDDALRVVQQEPYRLADEVDGVGFRTADAIAAGLGIARDDPQRIAAGLRYTLAQASDEGHCYLPAGELTRRAASLLSVTTAAVTDVFTQMVATNQLWRDPIVADPDPDRYPIYLPPLAFAEIGVANAIRRLIQQRSSLAARYAPSRWNLVFAHLAERRGINLSDQQRRAVQTALTTPVMLLTGGPGTGKTTSLRALVMLLQARGYRPLLAAPTGRAARRLSEATGLEARTIHRLLEYGPDGTFRRNAEYPLDCDLLVIDEASMLDIVLANQLLKAIPAGAHLVIVGDADQLPSVGPGRVLGDVIESGVVPRVHLDAIFRQAAGSGIAANARRINEGHLPEWGAHDDFYFFAAATPERCAALTVELVVERIPRRFGFDPRRDIQVLSPTHKGVAGVAALNAALQAALNPPRPGVAEYHSGATIFRVGDRVIQQRNDYDRDVYNGDVGEIVAVDPTGPTVMVRFEDGRTIRYNGLDLDDLTLAYALSVHKSQGSEYPVVVLPLLLSHQPLLQRNLIYTAVTRARQLVVIVGDRRAVEVAIAAANVERRYTGLSIRLGRT
The following text describes a protein:
Function:
Involved in the lipid remodeling steps of GPI-anchor maturation.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MAILPFRDKLDYSSAAVVIGFSLIVSILKAFSIKSEATRVMVVAPLIAFVTTHILYLKCYKFDYGKRSFPLIIQKGKDLFKLFDFLNLLYKDLNMKAYVIMGVAKVLIWGVWAGILNHPSKWKIWVMTIGEGLIILFQIYDFPPYKGFLDAHAISHAIVVPVSNIWWSFIHDDSEYRTKTLMKKAK
The following text describes a protein:
Function:
May play a role in vesicle trafficking.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein; Cytoplasmic side.
Sequence:
MNMPLLDIQPRTLQFAVDLKKQTSCVVQLTNTTHHYVAFKVKTTSPKKYCVRPNVGVVAPKSTCEFTVIMQAFKEPPPDMVCKDKFLIQSTAVSAETTDEDITASMFSKAEGKHIEENKLRVTLVPPSDSPELSPINTPKQGAVFEDSILKDRLYSQSETLAPPQYEGEIVKEPRMVGHDELKAADNAKELKTPKMATVDFVEDRYTANDLKATKDSYDSSRMAKETGFDPIRSHKDADDGRAIKATTNLDAPMKKAMDLPRDQGFTNGIAVDSEPKISKERDVVQLQKTDGQNVRGLDELKLVKDIEEMKLKVDALESKLKQADSTISKLMEERSISSQHRQSLQHELAELRTKKIVKEVHNGFPLLYVCVVAFIAYVIGHFLRT
The following text describes a protein:
Function:
Hydrolyzes the glucosidic bonds of unbranched Glc residues in tamarind seed xyloglucan, producing XXXG, XLXG, XXLG and XLLG. Has low activity on carboxymethylcellulose, lichenan,hydroxyethylcellulose and glucuronoxylan, and no activity on xylan, polygalaturonic acid, wheat arabinoxylan, rhamnogalacturan, curdlan, laminarin, galactomannan, galactan, arabinan and pachyman or amorphous cellulose.
Sequence:
MVKKFTSKIKAAVFAAVVAATAIFGPAISSQAVTSVPYKWDNVVIGGGGGFMPGIVFNETEKDLIYARADIGGAYRWDPSTETWIPLLDHFQMDEYSYYGVESIATDPVDPNRVYIVAGMYTNDWLPNMGAILRSTDRGETWEKTILPFKMGGNMPGRSMGERLAIDPNDNRILYLGTRCGNGLWRSTDYGVTWSKVESFPNPGTYIYDPNFDYTKDIIGVVWVVFDKSSSTPGNPTKTIYVGVADKNESIYRSTDGGVTWKAVPGQPKGLLPHHGVLASNGMLYITYGDTCGPYDGNGKGQVWKFNTRTGEWIDITPIPYSSSDNRFCFAGLAVDRQNPDIIMVTSMNAWWPDEYIFRSTDGGATWKNIWEWGMYPERILHYEIDISAAPWLDWGTEKQLPEINPKLGWMIGDIEIDPFNSDRMMYVTGATIYGCDNLTDWDRGGKVKIEVKATGIEECAVLDLVSPPEGAPLVSAVGDLVGFVHDDLKVGPKKMHVPSYSSGTGIDYAELVPNFMALVAKADLYDVKKISFSYDGGRNWFQPPNEAPNSVGGGSVAVAADAKSVIWTPENASPAVTTDNGNSWKVCTNLGMGAVVASDRVNGKKFYAFYNGKFYISTDGGLTFTDTKAPQLPKSVNKIKAVPGKEGHVWLAAREGGLWRSTDGGYTFEKLSNVDTAHVVGFGKAAPGQDYMAIYITGKIDNVLGFFRSDDAGKTWVRINDDEHGYGAVDTAITGDPRVYGRVYIATNGRGIVYGEPASDEPVPTPPQVDKGLVGDLNGDNRINSTDLTLMKRYILKSIEDLPVEDDLWAADINGDGKINSTDYTYLKKYLLQAIPELPKK
The following text describes a protein:
Function:
Biogenic peptide that prevents the onset of metamorphosis from larva to pupa. Has repressive activity against juvenile hormone esterase. Induces cell proliferation at low concentrations and inhibits it at high concentrations. Mediates the spreading of plasmatocytes to foreign surfaces. May have a role in the regulation of dopamine concentrations.
Sequence:
MKLTISILFCVILTLQYNGADGKLKDLFGKIHDSVHGTADKVKEDLNSLFHPNDKNQQGNNDASSNIHFADSEENTDAAKKPDEVTPATTTTTTAAPAVPNAPSDNPTTLAPSTTTKDGRENFSGGCVAGYMRTPDGRCKPTFYQ
The following text describes a protein:
Function:
Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.
Sequence:
MPQTWTLAALSRQVNQAAPQQARGVRAYSTATATATTMHRKSWELGLLLLLGLGSQGALPPPCDSQIYCHGELLHQVQMAKLYQDDKQFVDMPLNSAPDQVLQRFRELAATHNQSIPLEQLRAFIQEHFQAGGQELQPWTPEDWKDSPQFLQKISDPKLRAWGGKLHELWKRLGKKVKPEVLSHPEQFSLIYAAHPFIVPGGRFTEFYYWDSYWVMEGLLLSEMPGTVKGMLQNFLELVRIYGHVPNGARVYYLQRSQPPLLTLMMDRYVSHTNDTAFLRDSIGTLALELDFWTQNRIVSVSSGGKSYVLNHYAVPYGGPRPESYSKDAELANTLPEGDRETLWAELKAGAESGWDFSSRWLVGGPNPKLLSSTRTSKFVPVDLNAFLCQAEEVMSNFYSSLGNSIQATKYRNLWQQRLAAMKAILWDEEKGAWFDYDLENRKKNLEFYPSNLTPLWSGCFSDPNVVDKVLKYLEDSQILTYQYGIPTSLQNTGQQWDFPNAWAPLQDLVIRGLAKSPSPRAQEVAFQLAQNWVRTNFEVYSRDSAMYEKYDISNGGQPGGGGEYEVQVSGPHPTGDFVPTAGHDPPPPTLIWASDSSHYVGPLGGGQLELLCTPGARQFLGVWVGISQPLKDPTGPVSPGGLWLDQWSGPDAPGALW
The following text describes a protein:
Function:
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Subcellular Localization:
Cytoplasm.
Sequence:
MKEIILESLELKHRVYINNNLNRFHNILLENRIKDSDSIFIITDENVYNLYKHKMEQFINKNKYFVFVMEPGEENKNINTINKIYDFLMDNNANRHSVLIAFGGGIVGDITGFVASTYMRGLRFINIPTTLLAQVDSSIGGKVGYNHREIKNLIGNFYNPVFVYVSTSFLKTLSKREFLNGLGEIIKYSLIRENDLAYFIEKNIKFILEREQDKLIHIVKECLSIKAAIVEEDFRDLGMRNSLNFGHTVGHAIEANSSYRISHGEAVALGILVALKLSEKKLNLDKNIYNNVVQLYKKLNLPLFYKVDNYKTFLYAIRHDKKNREKIRFALLEEVGKVKVKVEVEENEIIKAIKESIDREEK
The following text describes a protein:
Function:
ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. May be involved in morphological and functional mitochondrial transformations during spermatogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Mitochondrion.
Sequence:
MSSKKNRKRQKEGAEGTSPSLSAASSRSGTSTPLAQPNVAAPGMLVVTNFLEKDGKVPKTFQNSLVHLGLNTMKSANICIGRPVLLTSLDGKQEVYTAWPVAGFPGGKVGLSEMAQKNVGVKAGETIRVQPLLGAVLQAQEMDLALSDKDKEINEEELTGCILRKLDGKIVLPGNFLYCTFYGRLCKLQVLQVKGTDGTTLGKPQSSSGTDVHGMASEQSSMESSDVDISFQLSQLDLKEPQSPASQSTPCKPINDRTMNKAGEVLLDVTQSPRDGSGLGLEEITGLKCSFDSSKEGNTQPISEEKLLKSTSAGAKNNTDTFYFISSTTRINLRKICTNSKEQDSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEGRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPHLLTKAELLRLANNAHGYVGADLKALCNEAGLYALRRVLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPSAMREVAIDVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFSRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREVFRKARAVAPSIIFFDELDALAVERGSSSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAEIIAVCKEAALLALEENIKADCIMKRHFTQALSIVTPRIPESLRRFYEDYQEKSGLHMV
The following text describes a protein:
Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSDKPDLTEIEGFDKSKLKKTETKEKNPLPTKETIEQERKGEA
The following text describes a protein:
Function:
May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.
Miscellaneous:
MISCELLANEOUS: Brain-specific depletion by RNAi leads to body weight reduction due to reduction of food intake without concomitant reduction in metabolic rate.
Subcellular Localization:
Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGMQPSPHELPYHSKAECAREGGNKASKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKKFNIKIKPLQSKDILKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARPRRSTPTPELTSKKPLDDTLALAPLFGPPLESAFDGHKTEVLLDQPEIWGSGQPVNPSMESPKLARPFPTGTPPPLPPKTVPATPPRTGSPLTVATGNDQAATEAKIEKLPSISDLDSIFGPVLSPKSVAVNTEETWVHFSDASPEHVTPELTPREKVVTPPAASDIPADSPTPGPPGPPGSAGPPGPPGPRNVPSPLNLEEVQKKVAEQTFIKDDYLETLSSPKECGLGQRATPPPPPPPTYRTVVSSPGPGSGSGTGTASGASSPARPATPLVPCSCSTPPPPPPRPPSRPKLPPGKPGVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQXSLVWFDRGKFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGITRHFANNPSPAALTFRVINSSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMSTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLAEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYGFSLIKKRFAAGKYLADN
The following text describes a protein:
Function:
Plays a role in determining ER morphology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.
Sequence:
MGLFFSKNNNFEKMLEMESKISNMEIKIEKSKEFHNSFFSNFIFFSFIIEIFLILISIYKSFSSNTMFENSWCYLLCILFSILFYIVSTLYRFFSGSLIRFYENKLNNLIIGFEKILNDIKVETDFETILKYENILKKKKCNNRVQQENLKPQQLQQPQQPGKSQKTQQPEKPQIINQNVQKLQKTPQNSKNKWWFDQIIEFLISFGSTSKSPLVCKNCGSFNGYVPGAKVSGIKFLCIECHFFNSYSLNNINEKWFGKLIDFLKFR
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Subcellular Localization:
Mitochondrion.
Sequence:
MSNKYNNLLKEVAAKYASIILNDAKIKSLTSINSAEYLYDSFVEISKLPLEKKLPLKWKLITVKENICTKTNLTTAASNMLKDYNSPFDASIVESLKKAGGIILGKTNMDEFAMGVKSENNLFGRTVNPVVKDSNYDVGGSSGGAAAAIAADICYASVGSDTGGSIRLPAAYVGCVGFKPSFGRISRYGMLAFANSFDTVGIAANNVKGVTKVFNVLDHPDINDSTCLTKEARYFVKEQHKKLSRKPIKIGIPIDWNVSETHPNVLDKWNEFISLLKSNGYLVQEIQLPISLYANSVYSTMAYAEATSNLAKYNTIAFGNCLDEKFEEEIISSTARSFFLGDEVKKRLLLGAYSLARMNSSDLFSKARYVRRAIQLEFNKNFFLPSFSVDDPRGDIDFIVTPSFFNSSQPIETPSSYSHLSDTMLVPANMAGIPSVSIPFGTLNNGLPMGIQIMAQYLNDEDLLSFAGQFA
The following text describes a protein:
Function:
Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.
Subcellular Localization:
Nucleus, nucleolus. Note=Associated with the nucleolus in an RNA-dependent manner.
Sequence:
MDALDKVLKPKTKRAKRFLEKREPKLTENIKNAMLIKGGNANATVTQVLRDMYALKKPYGVLYKKKNITRPFEDQTSLEFFSKKSDCSLFMFGSHNKKRPNNLVIGRMYDYHVLDMIELGIEKFVSLKDIKTSKCPEGTKPMLIFAGDDFDVTEDFRRLKNLLIDFFRGPTVSNVRLAGLEYVLHFTALNGKVYFRSYKLLLKKSGCRTPRIELEEMGPSLDLVMRRTHLASDDLYKLSMKVPKALKPKKRKNISQDTFGTTFGRIHMQKQDLSKLQTRKMKGLKKRPAENGVDDQGKKSKRIKKN
The following text describes a protein:
Function:
Catalyzes the hydrolysis of L-arginine into urea and L-ornithine, which is a precursor for polyamine biosynthesis. May play a role in parasite intra-hepatic development during the host liver stage.
Sequence:
MYECIQDYLTNHKDEKNIYVNKCISIVGSPLSAGQSLSGVNKACDNLRKFGLHDVIKAVGWGYEDIGNIGEKIPINGFLKQENIEKENDQINNNNPSYYNNIKNAEVIGKFSEKLFQTMSSELKKKNFILNIGGDHGVAFSSILSMLQTYNNLKVIWIDAHGDINIPETSPSGNYHGMSLAHALGLFKKKVPYFEWSEKLLHLKPENVAIIGIRDIDKYEKIILKKCNINYYTMFDIDKKGIYNIICEALNKIDPNKNSPIHISLDIDSVDSIYAPGTGTIAKGGLNYREIHLLIKSISDTKRVVSMDIVEYNPLLDESDKAVHGDSLPIDPNATKTGKLCLELIARVLGNDIV
The following text describes a protein:
Function:
Involved in a cysteine salvage pathway from S-alkylcysteine. Catalyzes the last step in this pathway, i.e. the deacetylation of N-acetyl-L-cysteine. This pathway is likely important in the catabolism of alkylated cysteine generated by proteolysis of alkylated glutathione formed in the detoxification of a wide range of electrophiles.
Sequence:
MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGIRRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRADIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQPAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEGKGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDTVVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLVRDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAIIKASYFLYESAKRLLDSNEESKISD
The following text describes a protein:
Function:
Putative transcription factor. Acts in a TGF-beta-like pathway during development of male-specific genital sensilla (simple sense organs), known as rays. Involved in production of reactive oxygen species (ROS), acting downstream of the TGF-beta-like dbl-1 signaling pathway. Involved in locomotory behavior.
Subcellular Localization:
Nucleus.
Sequence:
MNSLEYLIANPHILSDTTLTDALAALASSTNVENQDEEFDMEVNSDDEMKIDLSALINPSVFNALQLPIGTGRFPNPSPPRSSSGTNTPIRKTPGSRPDRGKFTILDNAEVAGPEEVLNVNFDSEILQRIFSDPKLGIQFLARYGLIPNTRVCRVQDCPKDQLMSLIKHANGFVWRCRSCRKRREKRIITKISVYEGTFLFYSRMPLNKFFIFMLNWCENPGLSITEYNRLMGENRLVEETIYNTIGFMRDIIQNWCDTIISSHVPIGGPHRVVEVVETLSTEQLSNKTRNRRTRHYTTRTVFISLADDKIKSVDFPLHNVNDLERALLECVQPGSIIVMRDSFMERFGQQEEISNALFNHYKVKSICDVWPDFNERERNKQYIKTEMNQVPNVNQEPYAYEYFFRRCFADKCFNHLLRVIRLLYQK
The following text describes a protein:
Function:
Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSELLSFALFLASVLIYAWKAGRNTWWFAATLTVLGLFVVLNITLFASDYFTGDGINDAVLYTLTNSLTGAGVSKYILPGIGIVLGLTAVFGALGWILRRRRHHPHHFGYSLLALLLALGSVDASPAFRQITELVKSQSRDGDPDFAAYYKEPSKTIPDPKLNLVYIYGESLERTYFDNEAFPDLTPELGALKNEGLDFSHTQQLPGTDYTIAGMVASQCGIPLFAPFEGNASASVSSFFPQNICLGDILKNSGYQNYFVQGANLRFAGKDVFLKSHGFDHLYGSEELKSVVADPHYRNDWGFYDDTVLDEAWKKFEELSRSGQRFSLFTLTVDTHHPDGFISRTCNRKKYDFDGKPNQSFSAVSCSQENIATFINKIKASPWFKDTVIVVSSDHLAMNNTAWKYLNKQDRNNLFFVIRGDKPQQETLAVKRNTMDNGATVLDILGGDNYLGLGRSSLSGQSMSEIFLNIKEKTLAWKPDIIRLWKFPKEMKEFTIDQQKNMIAFSGSHFRLPLLLRVSDKRVEPLPESEYSAPLRFQLADFAPRDNFVWVDRCYKMAQLWAPELALSTDWCVSQGQLGGQQIVQHVDKTTWQGKTAFKDTVIDMARYKGNVDTLKIVDNDIRYKADSFIFNVAGAPEEVKQFSGISRPESWGRWSNAQLGDEVKIEYKHPLPKKFDLVITAKAYGNNASRPIPVRVGNEEQTLVLGNEVTTTTLHFDNPTDADTLVIVPPEPVSTNEGNILGHSPRKLGIGMVEIKVVEREG
The following text describes a protein:
Function:
Involved in the degradation of ectoine, which allows H.elongata to utilize ectoine as both a carbon and a nitrogen source for growth. Catalyzes the deacetylation of N-alpha-acetyl-L-2,4-diaminobutyrate (N-alpha-Ac-DABA) to yield L-2,4-diaminobutyrate (DABA).
Subcellular Localization:
Cytoplasm.
Sequence:
MSKQPGQQRPSPISATVDFEADGVQHGFLKLPISNDESAWGAVMIPVTVVKRGEGPTALLTGGNHGDEYEGITALQKLSSRLRAEDVQGRVIIVPMMNTPACTAGRRTSPMDGGNLNRSFPGDPDGSVTEKIADYFTRVLVPMSDVVLDLHSGGRTLDIIPFAASHVLDDAEQQRRALEGAKAFGAPYAIMMFELDAEALFDTAVERQGKIFVATELGGGGTSTPESLAITERGIDNFLVHYGLVEGELQVPDEPQIYLDMPDASCYVQSEHTGLLELTVALGDPVTQGQVIARVYDMTRSGVAPVEYRAERDGVLAARRFPASVNMGDTIAVIAEVVESLG
The following text describes a protein:
Function:
May act as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
Sequence:
MSQSISDIKLVKFYYRHYKLGPQDFCREYGGNVDGLNKFLTGNYDSLAARDALRSFWERFNTNQLMKSQAGDEDDGDEFNSTFGGGDSMLLSPIKVTSPMSSSSSSTNTTNSNGQIIGNRSFSSLAEATSNATTTTTSTTTTGGKPESKRVRNLLKTYYGPGIGEGSDSSSMNDPLNIDGPSFNLNSYFDSIVKSSTLNQLIQKDNQMVSEIRTLDGDMKTLVYDNYTKFINATDIIKKMKTNVENMEEGMALLSKNMDLITNCSEKINSTLSVRRDRIDQLSGLQKFFQKLQFLTALPSSLNHCLAMQAYNQAVRYYNSNSGILKQYSHIPSFQNIQNECDSIMKTMKDKLYERLSSLSTSQTDCVESAEVLMDLLEPVELVRSKYLESRKHHTITLLENLEKKSVEHITDYIKELNANFLSEYSYNITSYKSLFINRLDGSDSKKERQQSLLQLEDFSKDLFNKYLNIAKSKLSSFKDPIEKIMALEIINSDVSRLGSELSSHEKITNIINSTVHDQIDFYFDNLQKTIKEHIHQLNSTLNERRDEVLEGHNLQELSDATSKAIVNDIILLFANLKPFFLPTETQFLSSYQDTIFTKIQVKLQQFFLFLVNIHFLEYLDIIATTSNREQFSGRFLLVLSSICLYFENKGITLVVQLMSEFITVAKQGAKKELNVFSFNAPDLCKRVRETGLQILNVFTRLSSQKLDKILKKGLESIPNNNWLVLKEPRDVRSVNDIYLEEILKFQNETSKLLPVINHHHHSLKSHSRTGSGGNSVSSNNSSSNTPDGHRRNPSASSSSSSNNTNTTLFEKKVDHVDFNTLSVLIAIIKLSLKSFNESLRLKTFGTNGCHQIQIDLHYLKLSLYDLFGSNSFDNLLQECENTVTERCVDPLPLAKSIVSKICETKMNKKKNNEAES
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Required for positioning of the mitotic spindle.
Subcellular Localization:
Cytoplasm.
Sequence:
MADMAKFEEEVNKLRTLEKDREKYFTSRQEMEMRLTESKNVKAELDLMESDSKVYKLIGAVLVRQDLEEARSTVEKRLEFIDSETKRVEASISDISKKCTEQRDKVMNMQKSFQMMAQAAAQAQKK