lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.
Sequence:
MHRLMVRGVVRGAAASIDSSSRWVLPGPKLLHTARPCLSDAGSNGDRRTQSPETSASSAAAPSTVDSADKNKSNSERERSQPTTAATASTLSDSFGRFHSYLRISLTERCNLRCKYCMPADGVQLTQKQQLLTSAEVLQLASLFVAEGVRKIRLTGGEPTVRKDLTEIVAQLKATNPLLESVGITTNGLMLTRQLVGLQRAGLDALNVSLDTLRAARYEQITRRKGWDRVMAGIDLAIQLGYRPKVNCVLMKGFNEDEICDFVELTRDRNVDVRFIEYMPFTGNRWDTDKMVPYRAMLETIRARYPAFEALPNGPNDTSKAYRVPGYRGQMGFITSMTEHFCGSCNRLRITADGNLKVCLFGNTEVSLRDALRSPGCSEDDLRCLISAAVKRKKKQHAGAPARSTTTTTNTSYAQTSTIFQRRPALQLQQPHRHYASLSHVDVHTGRATMVDVDDKLSTKRIAKAQATVYVGPTIAALIENNELKKGDVLSISQMAAIVAAKKTSNLIPLCHNIPLSSIKVETNLNSSTHEVHILAKVKCDGKTGVEMEALTAVSIAALTVYDMCKAVSHEILIKNIMLVEKTGGKSEFYRKQFSHDASTLETRTMEERTTERMPPVPPTRPYRTDPIVTNEQFVPMYI
The following text describes a protein:
Function:
Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
Sequence:
MMTGLSGKHIVLGISGGIAAYKSPELVRRLRDKGADVRVVMTHAAKAFIAPLTLQAVSGYPVSDDLLDPAAEAAMGHIELGKWADLVIIAPATADLLARMAAGMANDLLTTVCLATAAPIAAVPAMNQQMYRAPATQENLQTLSKWGVLLWGPDSGSQACGDIGPGRMLDPQEIVALAYNHFSAKQDLQHLSVMITAGPTREPLDPVRFISNQSSGKMGFAIAQALAARGSNVTLIAGPVNLSTPEGVKRIDVITALEMQQAVQKIAQQQNIFISCAAVADYRAEHVSDEKIKKQGDEITLKLVKNPDIVAGVASMAKNRPFVVGFAAETQNVEEYARQKLARKNLDLICANDVSLAEHGFNSDTNALHLFWSTGEKRLPLSDKYLLSQRLIDEIVSRYDEKNRH
The following text describes a protein:
Function:
Involved in chronological cell aging.
Subcellular Localization:
Nucleus.
Sequence:
MDLDYCIICGKPTTGNLYCSRECHLQDCPGCGSTSEQCSYSKSADLHMLSSQYLDHFRRRSSMPSPSTSSSLLNGFVASRLAVL
The following text describes a protein:
Function:
Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MWGRRRADIARAVLLLLVVGTVVYHGAKFYMDSLQLDTRHEVREVETENTEEEPQPVIADNAEKKEQLKPQVDIPPDPPKCGIQPPCSKDQFAFAISSGQAQRVGPRICFDGKDLVSDDTHNAGRGMNIVVIDGQSKEVLKKDSTMVFTDDAELIKFLQNRKEGQLVLVASYDDAAYKLTEESRELLSALGSQHIAGLKFRDSWAFLGYKGSHGPAPKEEVHHHVDRQDEWPQQAEIRGCAPLPTGAAVPEEQPGGAGAAVPEQQPGGAGAAVPEQQPGGAPEDSCATYTPHCDAGAPVYLFAGDKTKNHWPEICINGQYVIRGGKIGWRGLNVVVIDGRTFQVTQAKNFDTYEKGSSELEDLIWKMDETSLMLIATYDEASRSLSSYARSLLTDLGSSKVKNLGFRDSWVFIGQKGIVGVSPHEKHEKGGGQFGGAVEIKACLAGKLTGQKQEGVDSNVNRPRREFCETYNQAGEYGDFCSEENQKESLLPAPLGDQLDLRGHAVFATPIVVIARTALNLVQQTLESLRLQPGINPKMVQVMSDGSFDEPHKLANLYGFQWQSLQPTTKYVYQMHHAMARVFETFKDSKYAIFIDEGFRARPGFLRYFGQTLSLLDQDDSVFSVSAWNHNGFEGLSQDPSLVYRTEDFPATGWVVRRSVWESE
The following text describes a protein:
Function:
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.
Miscellaneous:
MISCELLANEOUS: PubMed:9525886 cDNA clone has a guanine nucleotide deletion that causes a frameshift near its C-terminal coding region. This likely reflects a somatic mutation in the ovary tumor cells from which the cDNA was isolated and may have altered the function of the encoded receptor, and contributed to transformation of the original ovary cells that formed a tumor.
Subcellular Localization:
Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.
Sequence:
MGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
The following text describes a protein:
Function:
In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus.
Sequence:
MAEPLRRRGPRSRGGRASRGARRARAARGRCPRAPRSPTRLIPDTVLVDLVSDSDEEVLEVVADPGEVPVARLPAPAAPEQDSDSDSEGAAEGPAGAPRTLVRRRRRLLDPGEAPVVPVYSGKVQSSLNLIPDNSSLLKLCPSEPEDEADLTDSGSPPSEDALPPGSPWKKKLRKKHEKEEKKMEEFPDQDISPLPQPSSRNKSRKHTEALQKLREVNKRLQDLRSCLSPKQHQSPALQNTDDEVVLVEGSVLPQNPRLFTLKIRCRADLVRLPVKTSEPLQNVVDHMASHLGVSPNRILLLFGETELSPTATPRTLKLGVADIIDCVVLASSSEDTETSQELRLRVQGKEKHQMLEISLSPDSPLKVLMSHYEEAMGLSGHKLSFFFDGTKLSGKELPTDLGLESGDLIEVWG
The following text describes a protein:
Function:
Polymerizes as an extended structure around the baseplate-tail tube complex. During ejection, the sheath shifts to a contracted form, thereby making the inner tail tube protrude through the host cell envelope.
Subcellular Localization:
Virion. Host cytoplasm. Note=Tail.
Sequence:
MAINQYGVNFNGRRIVHPGAYGSIDDSAMVVTSDGSSNIPIVIGTADSGKSGEVLWYTGVEDARNELGGGDLPQALEMMFSPSPEGGGGASLVGVIVANKTVPATATIGGVKFTAAEYGEGGNKIQVKLEDGSIPGSKKFTAYKWDTQDLDTFDNIGSVMSVAYTGTAKVAVIDVVVTDGVATKIETKVGEDAENLTVDLQLDLTNERYSTIEAVAQYLNSVSDYSASYVTSMSLELESSKLDAITGQDIKTKSYLTALKGDLEFRISQYADLVDVEVTGEIVNFDNTYLSGGEKGTTPASWSDYLDLIKKQYSDILVVLTDSEAIHAEALAHVQQMENRKQRQMLFVGGGKGEAPERAIERASLLNSSRAVLAYPGIYHSSYYSGSRELPAYFTAAMIAGRVAGVSQSTPVTFNKFNLVSLGRDMLAGDPEIDQLITSGVCTLEKVKNGAIRLVQGITTYIGSNNTLLREISVRRTADLVATSVEQTLEDTFVGKKGVSTTVSSVETVVSDTLAEKVRTEDIIGYGDIKVTFKNTMIYVDYEVAVVEPMNYILVRSHFVPDTGQFTTEEV
The following text describes a protein:
Function:
Helps DnaI load the DnaC replicative helicase onto single-stranded (ss)DNA. During DNA replication from the origin of replication (oriC) in the DNA replisome, DnaD is required after DnaA, before DnaB and before subsequent helicase DnaC loading. Component of the replication restart primosome, which reloads the replicative helicase on sites other than oriC. DnaB, DnaD and DnaI may also be required for a PriA-independent pathway of replication fork restart. DnaB and DnaD work together to allow DnaB access to ssDNA. DNA replication at oriC might originate on the inner face of the cell membrane; DnaB is essential for both replication initiation and cell membrane attachment of the origin region of the chromosome and plasmids. Weakly binds ssDNA , preferentially binds double-stranded (ds)DNA , and replication fork-like substrates. Remodels DNA, laterally compacts supercoiled plasmid and linear DNA, forms beads along the dsDNA. Together DnaB and DnaD form bipolar complexes on plasmid DNA. DnaB and DnaD are also required to load helicase on the repN plasmid origin of replication (oriN).
Miscellaneous:
MISCELLANEOUS: The dna-1 (dnaBI) and dnaB-19 (dnaBII) mutants show different characteristics for replication and membrane binding of plasmid pUB110. DnaBI is essential for both chromosome and pUB110 replication, whereas dnaBII is necessary only for chromosome replication.
Subcellular Localization:
Cytoplasm. Cell membrane. Note=Forms foci near both cell poles and in the middle of cells. DnaB interacts with oriC downstream of dnaA, truncated DnaB is specifically depleted at oriC and not other sites in the genome.
Domain:
Bind ssDNA via the N-terminus (residues 1-300), which also mediates tetramerization. A region in the C-terminus (residues 365-428) also binds ssDNA, dsDNA and is responsible for DNA-mediated oligomerization. Has 3 domains with homology to DnaD called DDBH1 and DDBH2 (DnaD DnaB Homology 1 and 2) followed by a short positively charged region and a probable C-terminal alpha-helix. Removal of residues 429-472 increases dsDNA and some ssDNA binding, while removal of 312-472 prevents all DNA binding.
Sequence:
MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFSLYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRPFNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSETMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQIERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPSKADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVREAMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQDLEEQKKKMMEEMQKLKKYSAY
The following text describes a protein:
Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MADSEFEEFHRPIFEPHTIAGFGSGAGSKKNNPHAFYSLIPNDDLEDSHSSKSDGDGSDQEDGIGLVDHEPKMRQVEDDELGDGLKVTLSSDGSLDTNDSFNSHRHHPLNHQDAIGGFLGMDTSGLGGNSAPVTIGASTDLLAPNTAATRRRRKLPEIPKNKKSSILHLLGGSNFGSLADEFRNGGGGGIPPAVRSGQQRSFLSLKCGYLMDEDSSPDSERMQSLGDVDSGHSTAHSPNDFKSMSPQITSPVSQSPFPPPFGGVPFGQLEMLEATHRGLHKFVPRHHDEIELEIGDAIYVQKEAEDLWCEGVNLRTGRQGIFPSAYAVDLDYNEFDPTVQLVKKERYLLGYLGSVETLAHKGTGVVCQAVRKIVGEYGNSPTGQTCILEVSDQGLRMVDRSGPNQNKKDKKPCIDYFYSLKNVSFCAFHPRDHRFIGFITKHPTVQRFACHVFKGSESTRPVAEAVGRAFQRFYQKFIETAYPIEDIYIE
The following text describes a protein:
Function:
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity). Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting galectin-associated bacteria for autophagy (By similarity). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (By similarity). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity).
Subcellular Localization:
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein.
Domain:
The CLIR and LIR-like motifs are required for interaction with AT8 family proteins.
Sequence:
MASDAPPTSMLQPEERNYSQVVFSRVEQSYVPGIDIICYFTYTSGFHPAKKDWVGIFKVSWKTTREYYTWVSADCEEQGLEKRVTFKAYYLPKESDDYYQFCYVDQKGEVRGVSIPFQLCRKIQDEGEEDILLVTTEEEAQGMKEKQRVLEEKVAALEKDKCTLQDECTQLALEQKNKAALIESLQAQQLECAKKNEELDQQNQELERQLEEEKCKNGSLHLKVVSAEEERERVQNDIRSLQLEQNQLKEENMELHKHTNDMEFSLKKYSEEAKNQEEEVQELKDKLWDAEAKHHLLQVQLQDIQMEKKKDKYSIELLTKEAEKVADLRQNLEKKDKTMETMEKQLAQLQRENATVLRQMEDLSYTLELRKAEISDMQQQRVRDGAEIEHLNRLLTEQSSSTPRNQGLFFQNPYESESLISFANEPQPGEAPGGSSVRHVQMQCPECGSEFENFQVFQDHIFCHDLESTE
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYSLYQNSQNQTSNADFILVGLFGETRHSILLYTVVFIFFLMALAGNTLLLILIHVEPRLHTPMYFFISQLSLMDLLYISVTVPKMLMSQVTGDHKISPSGCGIQMFFYLTLAGAEFFLLSAMAYDRYAAICRPLHYPLLMNLRVCVCLVSGCWFLGMIDGLLLTPITMSFPFCHSRKILSFFCEAPALLKLSCSDISLYKMLMYLCCVLMLLLPIMIISSSYTLILWLIHRMSSSESRRKAFATCSSHMIVVLLFFGAAIYTYMLPGSYHTAEQDMRVSTFYTIITPVLNPLIYSFRNKDVTEALKSRMPSGLCFRKAVKGKTQE
The following text describes a protein:
Function:
Proteoglycan that seems to be implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death (Probable). Involved in the regulation of root hair elongation.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MEAMKMKLYVVVLVAVIAFSTVHQTVAAVDAPAPSPTSDASSFIPTFFASVAVMAFGFFF
The following text describes a protein:
Function:
Siroheme synthase involved in methionine biosynthesis.
Sequence:
MLVNWSLKDAYVVVVGDGNNAAKRVAMLQEQGVKQVLWFKTLEAASSIAPKPSYTTSYSSAYSSSSSSYAWGAPASTGGSFSFSKPTVAEADAAAAAAAAAAKKPYYVQNGNVQEYDFSSLRIPESLQEMGSPERMNVVDAVFAVNEQKVKMDSLAKTCRRLRIPFNNAESCSYNTFNIPATWSEGPLQLALSTSRNGCRLAQRLLRHVVSTLPVEMPAAVQTYGKVRSLTQEDAQKSKWLSQITDYWPLEKISKLTEDDYHAVLDDEKTLTHPPIYTASAFKPSKKGQIVLVGSGPGNPDLLTVAAREAIQRAHFVLADKLVPGPVLRLIPRHTPVFIARKFPGNASNAQDELHELALEALEQGQYVVRLKQGDPFIFGRGGEEVLFFKKHGYSPQIIPGISSAMVAPAVAGIPMTHRGIADRFLICTGTGKNESSPEIPPFVAKQTVVFLMSLHKLRSLTESLISNGYPSITPVCIVERATCADERFIRGTIESIADIYEDIPDHRPPGLLVVGFACSAFGITEGSIDKKENIVEPSNVAKEDVAKKDVVTKDNVIQNDNSVKKETAALAGSS
The following text describes a protein:
Function:
Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Subcellular Localization:
Mitochondrion.
Sequence:
INGPISTAQFMRQALIHPLGGYYMKGKVFGPHGDFITSPEINQMFGELMAIWFMNHWQTYQSIPSTAPQKPFNIIELGPGRGTLMADMLTTLTQLKTSTINPLNAVHLVEASPELRKTQAQMLNCTMDPLENSTYRPGDGTTVTGTTSQGVKVYWHDTFDCIPVDETVASFIIAHEFFDAMPVYKFQKTEQGWREIMVDLDETPTLPYNFRFICAPSATKASVALMQPTVTDRFANVQIGERIELAPDVVGVSKAIAERVANDGGIALFVDYGRDHVIDDSLRGIRNHKIVHPLSMPGDCDLSADVDFSAIQHAVKGIANAYGPVPQGLFLEKMGIGARAMALIQGATDNKTKAAVVAAYERLVDPDAMGQAYKIMAITSSTTVPYALEPFQHHTEPSVDDEPFNPHK
The following text describes a protein:
Function:
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm. Endoplasmic reticulum. Nucleus.
Sequence:
MPQEGERPLPLIRSLNCRVPVSAVFCNRTPYVVRPLWIDYSGVPQAYEDLKPGSGRRMTTYVGHPWLFRDAVTDEPLKVNGKEFFLPKPAENGDVSVIITLPVDSLKDRALHVIRCLVQPEDYRKLEIARCLHEELEDQPNVLKDLQHINRLVERRMQERNQDQDV
The following text describes a protein:
Function:
Transcription termination factor required for processing and steady-state levels of plastid transcripts. Required for splicing of the chloroplastic Clp protease (ClpP) group IIa intron. Required for maturation of 16S rRNA and 23S rRNA in the chloroplast. Essential for embryogenesis. Required for the maintenance of the correct levels of transcripts in the mitochondria and chloroplasts.
Miscellaneous:
MISCELLANEOUS: 'BELAYA SMERT' means white death in Russian.
Subcellular Localization:
Plastid, chloroplast. Mitochondrion.
Sequence:
MKIRFCNGFTKPGFLLVHFEPPSFFAVRSRSLSDSTYGNLCNHKKRPGTGIGLTVQCAIANRRFSSRSLDSPRRERSSRSSSSSGRDRDRDKDKGRDSKSLYSRPSLLDMNKEKAANRAKVYEFLRGIGIVPDELDGLELPVTADVMKERVEFLHKLGLTIEDINNYPLVLGCSVKKNMVPVLDYLGKLGVRKSTFTEFLRRYPQVLHSSVVIDLAPVVKYLQGLDIKPSDVPRVLERYPEVLGFKLEGTMSTSVAYLVGIGVARREIGGILTRYPEILGMRVARIIKPLVEYLEVLGIPRLAAARLIEKRPHILGFELDDTVKPNVQILQDFNVRETSLPSIIAQYPEIIGIDLKPKLDTQRKLLCSAIHLNPEDLGSLIERMPQFVSLSESPMLKHIDFLTKCGFSIDQTREMVIGCPQVLALNLGIMKLSFEYFQKEMKRPLQDLVDFPAFFTYGLESTVKPRHKKIIKKGIKCSLAWMLNCSDEKFEQRMSYDTIDIEEVETDPSSFDMNTLMQPEREEESDSEYEEEEDDDDEEFA
The following text describes a protein:
Function:
Receptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal. Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol. Cargo protein-binding triggers interaction with PEX5 and formation of a ternary complex composed of PEX5 and PEX7 along with PTS2-containing cargo proteins, which is tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome matrix.
Sequence:
MSAAARTLRVPGRHGYAAEFSPYLPGRLACAAAQHYGIAGCGTLLILDQNESGLRVFRSFEWNDGLFDVTWSENNEHVLVTCSGDGSLQLWDTAKAAGPLQVYKEHTQEYNGVWSVGSGSGGVDKMTFPFLRCYVEVYSVDWSQTRGEQLMVSGSWDQTIKLWDPTVGKSLCTFRGHESVIYSTIWSPHIPGCFASASGDQTLRIWDVKSTGVRIVVPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFSVRFWNFSNPDPLLETVEHHTEFTCGLDLSLQSPTQVADCAWDETIKIYDPICLAMPA
The following text describes a protein:
Function:
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
Sequence:
MGNTPSFDPVREMCVQVAPATENSSYTVRHRNFKDRLIELPFEDEPDINTVWKLWKRGSVKFAKNDCMGIRSYLPNGKRGEFEFETYEEIHAQVEQLGGALDKLGVKAEDAIGIFSINRPEWMKSFMATMRQGAICVPLYDTLGPSAVTFILGDAGVETVFVSKENFDTLIENATEAKCVKTIIVFDPVTDEMRKKGEDAGFTIFSMDEFAKTCDKPGEPAERTTEDLVYYMYTSGTTGNPKGVRLSNKSVLSNVGAIIGIGIRLNEDDVYLSYLPLAHCLEALLQLTGLGFGASVGFYQGNIRLLTDDIMTLRPTIFAGVPRVYSRIYDKVQQTVEESGWVKKSIFDTAYKNQLENVRNGTRNPVWDSLVFNKTKMRLGGRVRMMATGAAPMPGHLMDFLKVVFCCDVFQGYGMTENAAAACVTPLGYLDAAGKVGEPIPSCEIKLADVPDMNYLHTDKPYPRGEVCIRGSNLFSGYHNLPDKTKEALDEDGWLHTGDIGQFLEDGAIQIIDRKKNIFKLAQGEYVAAEELEGIFKKSKYVGQIWIYGNSFHTTLVAVIVPDADTIMPWCKEQGIEGDFATATKDERVEKLISDDIRRIAKADKVASFKVPQDVIIENEINDMQQGFSPENDCLTPTFKLRRPQLLKRYKEQIDAIYEKRDGKPAKP
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation.
Sequence:
MDSGICYIKPEYLVTEADGGSAAANTENSDTNKRKREDGGEVEAGEKKKWDKKERKRGQNKNRPVFKDERYSHLCHSLIDGTGGEPCSLANCRYVHDLDAYLAAKGEDLGPECYVYTTKGYCARGVSCRFAKAHTDEQGRNLKREDYDENAPPTTCNGVSSELQVRLRKHEYDFSRSKELIKMAEKLRDARKLKEQQEKEKNPSEETGEKQPSETTEILDAEKQTDTKSKPTATGCAIDDSAIGRDADHKPAVDFREKLVLSPLTTLGNLPFRRICKEFGADITCGEMACAQPLLKGMGQEWALTKRHQSEDVFGVQLCGNNPNMLNQAAQVIHETAQVDFIDLNIGCPIDLIYQQGGGSALMRRTNILELTVRSCAALSDRLPFTVKMRTGIYADKSVAHELLPLVEEWGASAVTLHGRSREQRYTKHANWAYIEECAAKAKCMPVIGNGDILSYEDYMERRTLAPHVCSVMIGRGALIKPWIFQEIKEKQAWSPSSGQRYEMLQKFCNYGLEHWGSDTKGVETTRRFLLEWQSFLYRYIPEALQTAPPQKINARPQKYRGRDEMETLMSSGNAADWVKLSESLLGRVPEGFTFVPKHKANAF
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Sequence:
MSKTPDPNSTDASGSKSTKEEATIKVPSKDPKKKDDKKDEDLSEEDLALKQQLELYVERAQDADPGLQKVALESMRQEIRTSTSSMTSVPKPLKFLRPHYGTLKGFYEKMPDSDLKKLMADILSVLALTMSAEGERESLKYRLVGSQGEIGSWGHEYVRNLAGEISQEYVKRQSEEASIDDLMELVQQIVAFHMKHNAEPEAVDLLMEVEDLDLLVEHVDNTNYKRTCSYLTSSANLPPTYKLFSFDSGTIVKIGVDLLHYEPYLSNKVLRKPFFPIFSLLWMCQFLSGGSQGVKTPYLPGPDDMLVLDIAYTIYMKFEEYPSALVTALYLDNTQYVKQVFTSCDDLLRKKQFCYILARHGQTFELDEEMCAEDEEREGLQEIINNTKLSEGYLTLARDIEVMEAKTPDDIYKPHLLDGRASAGASVDSARQNLASTFVNAFVNAGFGQDKLMTVPSEASSGGASTSWLFKNKEHGKASAAASLGMILLWDVDSGLAQIDKYFHSTDTHVIAGALLGVGIVNCGIKNECDPALALLAEYIDKEDPSIRIGAIMGLGLAYAGSQNEQIRSKLTPILGDSKASLDVLAFTAISLGLVYVGSCNEEIAQAIIFALMERSESELGEPFARLLPLGLGLLYLGKQESVEATAEVSKTFNEKIRKHCDMTLLSCAYAGTGNVLKVQHFLGQCAQHFEKGETFQGPAVLGIAMVAMAEELGLEMAIRSLEHLLQYGEQNIRRAVPLALALLCISNPKVNVMDTLSRLSHDSDSEVAMAAIISLGLIGAGTNNARIAGMLRNLSSYYYKEANLLFCVRIAQGLVHLGKGLLTLSPYHSEHFLLSPTALAGLVTLLHACLDMKAIILGKYHYILYFLTLAMQPRMLLTVDENLKPLSVPVRVGQAVDVVGQAGRPKTITGFQTHSTPVLLAAGDRAELATEKYIPLSPILEGFVILKENPDYRDDQ
The following text describes a protein:
Function:
Plays a role in viral entry into host cells. Forms a trimeric complex at the surface of the viral envelope together with gH and gL. This complex is required for entry in host fibroblasts. Mechanistically, engages host receptor(s) including PDGFRA to mediate infection.
Subcellular Localization:
Virion membrane. Note=Host membrane associated, either via its interaction with gH, or as a type II transmembrane protein.
Sequence:
MGKKEMIMVKGIPKIMLLISITFLLLSLINCNVLVNSRGTRRSWPYTVLSYRGKEILKKQKEDILKRLMSTSSDGYRFLMYPSQQKFHAIVISMDKFPQDYILAGPIRNDSITHMWFDFYSTQLRKPAKYVYSEYNHTAHKITLRPPPCGTVPSMNCLSEMLNVSKRNDTGEKGCGNFTTFNPMFFNVPRWNTKLYIGSNKVNVDSQTIYFLGLTALLLRYAQRNCTRSFYLVNAMSRNLFRVPKYINGTKLKNTMRKLKRKQALVKEQPQKKNKKSQSTTTPYLSYTTSTAFNVTTNVTYSATAAVTRVATSTTGYRPDSNFMKSIMATQLRDLATWVYTTLRYRNEPFCKPDRNRTAVSEFMKNTHVLIRNETPYTIYGTLDMSSLYYNETMSVENETASDNNETTPTSPSTRFQRTFIDPLWDYLDSLLFLDKIRNFSLQLPAYGNLTPPEHRRAANLSTLNSLWWWSQ
The following text describes a protein:
Function:
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells.
Sequence:
MKVVDLALGILMVKCIFVWKCTYKCCLYPLYTLLSLFQSSDTSDRKVRRREKNRVAAQRSRKKQTQKADKLHEEYECLEQENSSLKKEIGKLTDELKHLSQILKDHEQICPFLHCPVNYVTVPRVTDAVPGCLPR
The following text describes a protein:
Function:
ATP-dependent 3'-5' DNA helicase/translocase; binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity (By similarity). Component of the general transcription factor IIH (TFIIH) core complex, involved in spliced leader RNA (SL RNA) gene transcription by RNA polymerase II. TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATPase activity of XPB is required for promoter opening and promoter escape (By similarity).
Sequence:
MILGPGGRIFINHGHPAYPHLMDFLTACCEPVCRTLYVSEYTISPSSLSAATAEGTYSMEMVRNVIRYFRLDEQQQIPVDVERYAALERRVRDSVQDTSLDLPMEVGEAKVSANGDVKAEEGCEEATDELSPLAGQVKKEETKEVAAEPRRRFLSLSKRISAKSEPLVTRAVVNTGALQPLPADLEQMLREEENSSRVRIVLQPCLRPVKRRAVGGDKQHSDEQQCQRAEETKLAYFLTSPDRNHMEHLVSRLQDFLVPVLLHGTRRWVVSDVDRGVEERSTAESGRAKTLRRLFEAPSSASGRSVASKSLTNEGANGDGLGGGVGRRCTRIVYKSQVMDGKMRNVRERLYKELSVRADLFYDYVQDHSLHVCDLELSENVRLRPYQVASLERFRSGNKAHQGVIVLPCGAGKTLTGIGAAATVKKRTIVMCINVMSVLQWQREFIRWTNLSEDQVTVCIADKKQMPGDVFITTYSMLIARRSNVPEMEQSADAKLTAKILASVGEQPWGLLLLDEVHTALAHNFQEVLNKVKYKCVIGLSATLLREDDKIGDLRHLVGPKLYEANWLDLTRAGFLARVECAEIQCPLPKAFLTEYLESQSDGDPFARRGTTRMAHSVVCLNPYKLWCTQALLEFHRNRSPPDKVIIFCDQIDGIQYYAQHLHVPFMDGKTSDMERENLLQYFQHSDNINAIILSRVGDVALDIPCASVVIQISGLGASRRQEAQRLGRILRPKPASLDNVCSYFYTLVSQDTHEISQSYERQSWLRDQGFSYRVLQSDMVLQHFLRTGGKLCCVGPPRWWYECAGPSCDSAVAAKGTYWIPFSQEAALRMQSRFVAGVRGCDLTATVLRDTPRPPELKNMGVEEKWTVCFSDSCAPETFGTVQLVEGNPLLVRRICCGPLAVEHDCLHGGEECLQYAVQQMKVMVAKNSKNRIPLTT