The following text describes a protein:
Function:
Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization. Binds to regulatory DNA sequences containing a 5'-CAGGTAG-3' sequence motif, which are highly enriched among developmental enhancers. Within 1 hour into development, or by the embryo's 8th nuclear cycle, binds the majority of its motifs genome-wide. Zelda-binding promotes nucleosome depletion and chromatin accessibility, thereby facilitating the binding of patterning transcription factors, including the binding of the dorsoventral patterning transcription factors dorsal (dl) and twist (twi), and the anteroposterior patterning transcription factors bicoid (bcd) and caudal (cad). Promotes the activity of patterning transcription factors, such as bcd and dl, by lowering the concentration threshold required for transcriptional activation. Required both for the earliest (minor) and major waves of transcription during ZGA. Also involved in maternal mRNA clearance during the maternal-to-zygote transition by promoting expression of microRNAs (miRNAs), such as miR-1, miR-9a and miR-309, which mediate degradation of maternally-loaded RNAs. Also involved in post-blastoderm development: nvolved in nervous system development by maintaining neuroblasts in an undifferentiated state and equired for wing disk development; [Isoform A]: Constitutes the main isoform expressed throughout development. Transcription factor required for zygotic genome activation (ZGA); [Isoform D]: Acts as a dominant negative inhibitor of transcription factor activity of isoform A; [Isoform F]: Acts as a dominant negative inhibitor of transcription factor activity of isoform A.
Miscellaneous:
MISCELLANEOUS: 'Vielfaeltig' means 'versatile' or 'manifold' in German.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
C2H2-type zinc fingers mediate DNA-binding. C2H2-type zinc finger 2 serves as an inhibitory domain, and is essential for reprogramming the early embryonic genome, but not for its functions later in development.
Sequence:
MTSIKTEMPPLHAAEALASSSATDSGGGGAGGGGGGGGGGSGGPGAGGTGGVGSAPATPNATISAAADSSDNQPGTPQPTQQQQSTQQQLQQPQSQQQQQQAMGGGDPQQQQQQQQVTGITHQPYATHHMYSASGGQQQQQQQIYGGLYGGDMQQQQGYASSYINSYEQFYQQQQQQQQGTDYAFGTVGVDYGKSAGVRYHPYLQTPTSGLGGIPTASSAQEEAGSAPSAVSTTTAVAMSPRVVSSSSPTSTSSHLQLGSSSGQTPGSPGGAAGSAGCKLQCKKCGILTTNESELQEHIANVHGESPYGSSGYASSPYIKEEMPTPQPPGVGSATANPGELLDLDSQKMVYHQQLLQQQQQQHDVVAGLPLGALPDPLHSMQSMQQRALHSWEQQPQQTVASVEGLPPYMQQGLGVGLGVGVDKSPYYSPKQSPYHQSTGVGGATLIKQEYGGHGLIKSEYPDSQHYVDKSFDPTAGGAGGAELCASVATSPAEFPSTTTGGPGQEGAAGAAPGGGYRGFEPPSSSSVLPANSLTAKAATWKSNEARRPKTYNCTACNKWFTSSGHLKRHYNTTLHKNAVKSSGQPDPATLPISAHHHPARDPVTKPSRRGNAAAAAAAAAAAASASGQGQQQQPPIPPPPANVPPPEPPRSPPDYGGGGGLGVGAMGGAAMSQYSASPSPTQQQQHHLNHHQQQANGYANGTANGYGYMQQQVQSTTNASPQHASNNNSNNQQQQQQQQQHHQQQMPQHHNSVLNGHPNGLAGPSAPHNNNTTQMPSSQMRGLLNETTTTPPPTTTTRAPQITTTATTTTTAATTVAIKSEQMEDSNHTHTHTHTHPNHSHSQDRSHSSSSSSSMATEEAEEQELRDQEQADDHLHQHQQASQQYLLSARHYHSSTPNTLSSSNTNPSTPSSNSPHTIYRQEQQGTDFSRTTPPPQPLPPMGMLPPMAMDYNMLALDMPMPMPTLMHSNMLQCSSTSTTPLATTITTSMPDTMQPPQQQLVHHYQAVLHPLHQQLGEQHQRQEADHHQQQRELHQLDQQQQQQQALILADSLPHSSSSPTSSSPPPTMPMPLTTITAPQLLPLQPPPPHITSTMPMPPTMHMPIMPPPPQCYQQLQPLDPTMSYHTIIGSGPEAHTGTAGGGYSNQITTSDGQILQLMPTSLFAPYAPLSPYSVAAQRSPQEGDLPPVHTLTTALHAHQQGGQQEAQTPTLTVLSTPYSPTVSSSRATPALEMDMATLMQHHQDYEMEQYQMQHQQLDQMQQHQQQLDHQQQQQILADQTQTMAQQPLAKKRRGGNATPSTTKRRRNSSVGSTSPHSTTLPSGRIKCLECDKEFTKNCYLTQHNKSFHSGEYPFRCQKCGKRFQSEDVYTTHLGRHRTQDKPHKCELCPKQFHHKTDLRRHVEAIHTGLKQHMCDICEKGFCRKDHLRKHLETHNRPRVVGKKSAAAAAAAAAAAAVTATAGLGGAPAAGSIKAAFARSLTVTAVSSEPGAGVAIPSAPATATCAPVSVSASALVQAVNPSLTSGLSLKRHIDDVAVDDDSLLEEDEDEMEMEMEMDMLEEEDEEEEELGDHHMIIKSEYVQEEFQMIEKSIELY