lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Sterol O-acyltransferase that catalyzes the formation of stery esters.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSSSADIYTNGNSHDQILRPRPQNIHNSTTIRKISEEGLLPVNGIKDVSDDGISTGPTSGRTTPVPEDAPPSVQSMFSAKRQIKAEQKRRIFPIIEYTSRVSHLDPHSDHHDFTGFYILFWIGLAIMAITTMLRNIKDTGYPMRVEIWQLFTVKVWELAVADALMVASTSISLPLHKFFRSKTAKALGLQWTRGGMVIQSLYHIIWMAFWVSIPFYRHWTWTAQVFLLLHTMVLLMKMHSYAFYNGHLSETERRLQELDSPATASKAPAYQYPSPSPGHKRTASEIRALTQTKADEIAILREDLAIELTSTMGSVTYPKNLTWYNYADYVFCPTLCYELEYPRTNGIVWSELGYKTLATFGVIFLLTITSEEFIHPVMTASAIKLQTSTSITENALVIAESISLLLFPFMITFLLVFLVIFEFVLGAFAEITCFADRHFYSDWWNSTDWMQFSREWNIPVHHFFHRHVYLGSRSYIGKGGATFITFFISAIGHEIVMACITKKIRGYGMVAQMSQLPIIWLQSRPWARGKKVLNNVCFWCSMILGLSGMCSLYVLL
The following text describes a protein:
Function:
RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation.
Subcellular Localization:
Mitochondrion. Cytoplasm, cytosol.
Sequence:
MSSKEETPSTGGAAPVATVAASGSATTSYANVVQNLETKKSGTSNTTTTTARATVDNKENQPNLKSFKSWSEEAAAAEAAGESPIVGSVSLAQTGEKRAAASGGDNTAENSSELDDNNDFVPVLSHHRRDRKKARKEKPRDQQPAGGRGDGQKPQQAGGRRVPGSSDTERKSVRPRAPRGGSPRKSAAGAAGAAGSNAGAVSSAVPGGPKVHKDRKDTSPSASIEGAGSSGNEAKSADGDQQAGEKGAAGAAPPPKRFIAAPPPKVNAWKISAKQSGSPKAGTSPLDKRVLQPKAQQQQQQTKQTASQNNNAQNTASNKKTQQQQQPQQGATTTTQTTTAAAAAATAAAAATAATTSAAAATSSAAAVPAATTETATTTTVDASQADALAKVVVKDKKKVNQKASDFSNVGDWPTLIGGTSGSGKATSNEPKRNPTKKQQSAKTAAAVAASSNTTSSEVATESNVAGTTSSSNSNPSSSTTTTNTTTNSQATTAPVASTSHDAKAQRDAEPAANSAAGTTGTAAGPALTKKIPKHKWRPLPIDLAKSSRPKPIGGRPNRRFSDDIADQRRPPRVYHDRQPGAGGAGVESRHPHAGRHPYGSRPATATSERVDSWRSSSSTTTAAFDEQRSGAAGGAGAAGTGVGSATRGPRRYRTPYRGGRQGRGGFSRQGPGRPTYRIPRHLLASGEYANYLPADAAGADSQSSYVLMGTHYFGNVPAAYIELDANSIKEAIKKQVEYYFSVDNLTGDFFLRRKMDPEGYIPVTLIASFHRVLALTTDVAVIVNAIKESDKLELFEGYKVRTKTTPTTWPITEVPEVNEGEPKAIGTLEQEQLEQNDGQEKLEEQTEADSPPPILTSAMATKPLNSIPPPPMPRNPQNLVPKMLQDKQQSRSSTIAALNSVNAISALTQQVEGGAAELAGHLSGLAESVKPKSTSTPDKRNAASAGNGAGSAAALVAEPEGIWKEVKRRSKTNAIKENATTPPQQQQPPLSQTLNNNNDNVKTNNTSSKSKSSSNNAPSNASSSATVCVTTNNASSATKATTKTTTTSTATTTTNNNIKSGNAAYSKTHSKSSSKTAAPPSAQCHAEKEELDFQFDEELMDPLPPGTGRINNFTENFSDDDESDYEFADRDINKLLIVAQVGRAPKHEGYDRTADFTSRTKITQDLENIINDGLVNYEEDLWTTTNVVADYKTVNVISQADFEKLAGGRNKSVLPPQVVPPPPPFEEDLDETLVGDTTLNSTLNNTLKSRRARFYAAPNSHSIDPRTPRKRKLRHTANPPVEAHVGWLLDTVEHRPRTTSMGSSAGTSPTASSYGSFGSSVPQSLPVFQHPSHALLKENNFTQQAYHKYHSRCLKERRRLGYGQSQEMNTLYRFWSFFLRENFNKSMYNEFRSLALEDAGNGFRYGLECLFRFFSYGLEKKFRPNIYQDFQDETIADYETGQLYGLEKFWAFLKYYKNGEKLEVQPKLAEYLKSFKNIEDFRVVEPEINEMLQGVGSLNPGRQLNRHRSVSESDGTAVIAAGGRRLNTTITNRSDYVGRLLQQQHQQQQQQQHHQYQQGYGGYNQQQNRRRTGSFGSTTVRIRSGSLGNKPQVANRNQGSQHELRRGGSNSGLAPHKRQQQQKPKPGAGSQTGSTRATTSAAATATTAASAATSTAATPAVTVSSGSSSSKK
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MLYLHVIQYFGFIGSQLANSLLIYLILTKARKLFGMYRFVMLGFAFFFLFYSWIEILTQPVIHIKSPVCIVFMDSSLKYFKSVGFIITCLYCACFALVISLLSAQFFYRFLAVCKPHILSHGEERLLFYLCVPCFLCFVAWFEFVYWGMANTVEKQLYMKSELAEIYNEDSESVAFIAVMYWSVGPDGQKKWKINDIGLLLACVVTIGGCFMTIVYCATRIYKKMKDSSGHMSGRTMELNRQLFITLTIQTILPLFMMYIPVGLATSLPIFEIHTGRIANFTAASLAVYPFLEPIVPMLCIKEFKNFILCRQKRKVASRTTFSSPVSGIHSSSTNAIL
The following text describes a protein:
Function:
Binds to all microtubule populations.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNYHIERPTSRVIRPPGGGSSNIFGSTNPEPDNLKPSDNPNYTSTVFDHCSKGVESGTTKSVVRRDPITGEVIDDGSNVKQTKQEENDEKEIETKTSSFDDKENSSVSDHEPHLGPIRSTSGVRCAQPPGGRSSITFG
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPTVRYLIRNEYGLADPELHRAADKDDPEAILEGVAMAGLVGVLRQLGDLAEFAAEIFRDLHEEIMGTAARSHGLTLRVQQLEAEFPSVEKSFLSQSSHSSFAYNDGIDWRCTIQMDQNLITQGDMPRFILDSYEECRGPPQLFTLDKFDTAGAGACLKRYSDPSFFKMESVSSGLLETYIPKEKKSRKTRKKGSRWRNCQSLESLLSPHANSNLHPTTSDQVSNKSATKFRRLRSRNSNGTSGSIGINLRKLLLELHSDKQKVVYDNSGSRLNINVNLVDSSELTCELHDTVMDVSANHPLARYASPIKTPTKEVPVLTTYELDCWKEEVEELSEAQYEPFGQVQSPQRIFNFMEKNEKLADSEKKSEGSACDYKLSDLEKTTSLHVVDYTLVEDELKLEGSLDGYRSEDIGSQILVF
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B. Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53. Catalyzes monoubiquitinates the translesion DNA polymerase POLH. Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation.
Subcellular Localization:
Cytoplasm. Nucleus speckle.
Sequence:
TAKKQCRAVSREHLYETPAKMAASAMGCEHYERSCSLKAPCCGKFYVCRLCHDAKENHQMDRFQVKDVKCSVCNTIQKAQQTCEECRVKFGDYYCDTCHLFDKDKKQYHCEQCGICRIGPREKYFHCLKCNLCLISDLQGNHKCVENVSRQNCPVCMEDIHTSRIGAHVLPCGHLLHKTCFEDMSKTGAYRCPLCMHSAWNMEDYWDELDKEISQTPMPTEYRNVTVKILCNDCQTRCTVPFHVLGMKCSGCGSYNTAQDGGLMPQEDTQ
The following text describes a protein:
Function:
May play an important role in spermatogenesis and/or testis development.
Sequence:
MAAVVLGGDTMGPERIFPNQTEDLGPHQGPTEGTGDWSSEEPEEEQEETGAGPAGYSYQPLNQDPEQEEVELAPVGEGEDGAADIQDRIQALGLHLPDPPLESEDEDEEGAAALSSHSSIPMDPEHVELVKRTMAGVSLPAPGVPAWAREISDAQWEDVVQKALQARQASPAWK
The following text describes a protein:
Function:
Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDFTEIHKRSRRKKFQQIHQDRKDEMIQQLGRRFHNQPSTSATYPSAVEDIPLPSEVPNVFGAPPPLTNADFHRNFLVDPDVVVSHSASLIRSNRHIVKAEDAEQYMMVSRERVGTTAERVLEDFNSRVIKPLKAKRRLQIDVPYIDHPLHSMRSKTPERKENEEDSDSEIRSSDSSSDAEYGSDVEEEPDSCRRKKRTHKIQKADSSQTKVEEKERQNTLLRMGIERKRNHPNAIDPHISYNEKGLGNDSPECRCPFPIRNRGLKHGYYAGENQVLKCSKNDRANLHYYTLHVTPAPNESQIQKTQMLINGMEYHFEGFTMVTHAPLPDCMTRRPVFKYSIDYEFQLIEEFMPTECFDPEDCNSIFEYIFHDIFELLDFDLYPKHLPPGTASCPTIHIVPRFVAMENNTTFIWSSKTVLAFFLLHGKNNMFSPEDVEKNCAMSDDAFGRTIAKLKQSIVLNPMKKPSALRADWFSRDLENKEMFLIQNTIRSQNFASPFLPQIAALEKKMSRLKQEKKDSGNKNPHYENLKAELIVLKDKHREARQLKLKLPVKDYIDTGLKPDVVAHVAMAIIASHHIRYNFSLSVFEKVIEYKFNDRRIVELALIHSSFRSYYGTTPDHVKNMISNCGYRKKYGAEERREKKKGIISLFNIMGGETSGGEPILHNERLEYLGDAVVELIASHHLFFILNHHFEGGLATYRTALVQNRNLAKLAMNCRIDEMLQFAHGADLINEAEWKHALANAFEALMAGVFLDSGIAPCDAIFSKAMYGKDPEMKKVWDHLNEHELKIEDPLGDRDLSRITPALTDFHRLEQIIGIEFNNIRLLAKAFTRRNVPFNDLTKGHNQRLEWLGDSVLQLIISDYLYRNFPLHHEGHMSLLRTSLVSNQTQSVVCDDLGFQEFVIKAPHRKNDLKMKDKADLVEAFIGALYVDKGLEYCRSFIRTVFCPRLKHFINSEKWNDAKSHLQQWCLAIRDSRNPNPAMPEYRLLGIQGPTNNRIFRVAVYFRGERLSSAAASNMHTAELKAAENALAALEKASFSRMREKYMSGRQHRLHRIFFS
The following text describes a protein:
Function:
FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Oxidizes thioredoxin in vitro. Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space, and can act independently of the oxidoreductase MIA40. Can oxidize the cytochrome c oxidase assembly protein COX19, a typical substrate of MIA40.
Sequence:
MGGRRPIIQESRMRSPGEDEEPTATLQRPSPKHISRLPAHLQLNPPPAPRKLPTAGALVSEQPVVNAAAVALGASVSEAPAGPDVGGTAVPGAGTHMPNAAAAVSEAAATPAARKLSDCKSRACSGVLKAFKRALHEEGQTAAAGPPSPASSLAASSPAPAPPPAPGASAPHPAAPASATIAAAVGTAMGAAACAAEGGAASGTAGGGAGASGAPPLPCPPDTWELGRATWTFLHSVAAGYPESPSERQQGLMRGMVEGLAEFYPCEVCREHLREQVAARPPQVGSARELNMWLCGLHNEVNEMLGKPLFDCARVGERWREGPADGSCD
The following text describes a protein:
Function:
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
Subcellular Localization:
Nucleus speckle. Cytoplasm. Nucleus.
Sequence:
IVWSRDQRRKMDLENPKMRNSEISKQLGYQWKMLTEADKWPFFQEAQKLQAMHRE
The following text describes a protein:
Function:
Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).
Subcellular Localization:
Cytoplasm. Preautophagosomal structure.
Sequence:
MAMESECNVVELIGGFFLKATLLVCQPRTGAIEGDGEEDRTFNISSAADAGVAEAVRAWTAYDGAQELPPLVIEMFLDLRRLGPQHTVVLKDQDGNPWNVCKGGKKSEIMLERWLVELDVGNEEARPEEPPNAAEIYKQLVLLFRYLYTLTQLLPANELYARLHGPSNQGEAAMPLINIGTRILDGSKPILSKGRVGLSRSIIATYTNVINETNVASHLEQKKITPISTGYGSLRITVSYRRDCNFDVNEVLDYEGNNCSSSSVVDTHTKPGVGPLSSLRRVSIHSNRSMSISPQTVYSGTVIPDPSPQRKSSSSRIQPFKAGSVGSGSLAIARNPSGSSAVATLRAQRSGSASISTHVADQAVGEPSSVGSGGSKYSSSFGKIRRQSSMRRSGSLELPAAKQAKPGERGSDELLDFVKMLEEKQELNVKKLYGTTTDISSSLVRFQSMKSNNDTLSEDLSMSYSLEPTHAPQVRYRSNSHSPIPSISPSVQYTSIPMRLSQSRNVSQTELASRKNSAERLKTLISSRTGSFSESRRQSNAGQEDILEDEDDEAEEILLSKSHLSNPTGTRLQSMSPQSLKSISSYNRAAVPFKPVSNFSCPTTMATPAHAKLHKASISSSPDNQSGLVKKDHEHSTMTGGDDDDDLLFFMSDMNLSSQ
The following text describes a protein:
Function:
Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS).
Sequence:
MPAKTRNVLIACSDYYGPFYKDGENTGAFFLELLHPYLVFRDACFNVDIVTESGKIQFDDHSVAGPAIDKGSKGEEFLSYDDHIASGPELSKAEKYVLENKDDMFWRIVQNSKTADEVNPDKYDIFFVAGGHATLFDFPKATNLQKLGTSIYENGGVVAAVCHGPTLLPFMKRQTSDGSVSIVCGKDVTAFDRVAEDKSKLMEALKKYNLEVLDDMLNDAGANFIKSPNPFGDFVIADGRLVTGSNPASATSTAKTALRVL
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Sequence:
MADETSTKTRTMRLGMCEVCAAKEACYACPKCEVKTCSLPCVQIHKKELNCDGQRDRTKFVPLSEMTSREFMSDYCFLEECTRYAENRKSDPCKRFTHDQRNLPVTQHRMRMAAKKRNINLRLQLENFSRHKENTTYLNWKLGRFHWRIEWLFANIPYEASLPRNVTRFVDKECNEELTLPDLVAKYVDLRHETAREQRKLLANHQTAGIGQLSFWLRAEGVRRSSTRCYLLDSTKTLAENLVGKTIVEFPTILVTYDPKPPGGYEAIDSSEEFEEEHEEQVPVTKPGTSSNAVAEDLDDSHDVYYKLAAAFAGEDVSETEDDEEFEALYRQSVVL
The following text describes a protein:
Function:
Catalyzes the isomerization of glucose-6-P to fructose-6-P.
Subcellular Localization:
Cytoplasm.
Sequence:
MLSYDYENALKVGEISLEDINKVDFANAYSNLMEKLDNGVVGFRDVIYDENLDKYKSLNGYENVVVIGMGGSILGTMAIYYAISPFNNNAYFIDNSDPEKTLSILKKVDLNESIIYIISKSGNTLETLVNYYLIKKRIEKLNSFKGKLVFITNGGKLKREAEKNNYDIFSIPENVPGRFSVFTAVGLAPLYSLGVDISKILEGAREMDKICQNEDILKNPALLNGVIHYLYDKRGKDISVIMSYVESLKYFGDWYKQLIGESLGKNKHGITPLLSIGAKDQHSLLQLYMDGKKDKIITFMVAKKYRLDEEIEFEDINDEKISCRYSDIIRSQQKATEIALTNNGVPNVRITLDEINEMAMGALLYMYEMQVGFMGELYNINAYNQPAVEEEKKICWRLIKQ
The following text describes a protein:
Function:
Required for ciliogenesis and sonic hedgehog/SHH signaling. Independently, involved in regulation of cell intracellular organization. Involved in regulation of cell polarity.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MEAESGSSTSQDSLASLTAGDVLVRSTGVRGVKGAAGAGGRNSAAVSVTKLREALPSRQAAGVALSRGETPCEPPVPSSGASNGRVTGVTACSAAPGVWNAKGHPEHLLLVADPVEATSVPQMVYPKEAAVNPKEADRSLQPEYSRRPKDDVLISRYPTGQKEALRAVLKQKTRSAPVFKEVKVQLLGNASPERKESVGQDPILTHREADSATTIAAATAAAIATTAPLLKVQNDLQAKVNCVSTLLHKLQETDKQLQRVAEQQTNTKTQHEKPHCHERVSELEKQMNAFMLQRIHHLEKLQEHQMNIQSHFISSAVNMGGLQQTHMPSSGLLTKQSEKAEEQLLNNGISSSQKNFFPSSGLPTQGDGRHLEHILNPQAAPWGQMESSEKTMLTNDKMSWHSEIERPTALQTDSCPAYENSSQNCNSIEKTVKKADDLLQVLGQLRKEMHDMLQEASSWKSDMNDLIKSKPATIASDPPEYNHLVKPSVLQNVKAPNSILSDAKRVLREVQSRKKVLEENLEAVLRAKGGGAMSAFINALTTNRDALEKIRIRKAVDERIKAISAEIQAEMARNDMEQVKYDQKVPWIKRAQNIKAMKNSKEIKAKTQKIQGCSTKKPLSAAKSLRNHVEDNISKEGFRTYFSSESLQRNRKGTDEPMSGCAMVQNEEYLSQIYGKPIYQGHRSTLKKAPYLRFNSPSPKSKLQRPRVIEYVRGTKVKSAGTQTCSRAQKAVISSKKQHPLYALAQENQYFFSPNRDVPADCGPLEGHLIPMAVPLGQTQINDISVQPAGVVMCKPHPVTVTTSIPQVPPKPPTEVKKPNVAVIEMRSEKKDPPQLSVQVLPNVDIDSISGGSVSVNHVLPEPKPARCPADAVIQAPEDIQSEEEDVKFPGTNFTDVTDVVQDQEEERDEIPEFTEPLLEINGHFRVAEPTYNGPSFPPVASAPQQSCDVLDEWIERRETIENRLINWVEQEIMAKIISEMYPVQRETVPSVSTSEGEDSETVTSDIVEAAGGGGFQLFIDAGVPVDSEMISHLVNEVLSETIATMLGNRQAQEAVPATNLLPSTTAVMEPLVPTPLPTPQATPPQTPPSEKEMPPVQTPESSPSITELSGDVREQEKMKEAGSDIPAAVSRVGTPVITPISTPPEIITPSPPASEAAKMENPAPLNPWDDAELPLEEEKPSPLAEETFNPKAVEMSVANDEEPEALILPSWQSSPKPFQSLPCEPEAPSAAPTDSSEQSTQESSLTPTETETADRPISEGEVLFSCDQMLAAREGGLSFPNLTESLTSTLQDANEMDYDPPSEGQVVRRSHKGYHRDPVLALLAKLNQAPVAVQEGGYHLEDSDSSVGELSEGQRPRLTRAAERILMGHPVDIDHATARASEDRPYQGSRSPSPGQLTHPAEILGDADTSHGPMLVAELESQPISNPVLQAAQPSCRVASLPKGPSQEESQGDARVVRPRVVHVRRKSEEMQEEGEGVVPHFHSHVSAERMSVKLPSMNIDDQTQSLSSIHGDSDSSGADTF
The following text describes a protein:
Function:
H(+)-stimulated, divalent metal cation uptake system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSSEIVPIAEPIRPADGGLGAAHASVAVPKGGHWWFRLLAFLGPGYMVSVGYMDPGNWATDLAGGSQFGYLLLSVILLSNLMAIVLQGLSARLGIATGLDLAQACRARYPRGINLALWGLCELAIIACDLAEVIGTAIALKLLFGIPLTLGAIITALDVVLVLLLMNRGFRALEAFVMALLLVIFVCFGIQIALAAPPIAAVLAGFIPRAEVVTNPHALYLAIGIIGATVMPHNLYLHSSIVQTRAYPRTDAGRRSALRWAVTDSTVALMFALFINAAILILAAAVFHAQGRTDVQEIEQAHALLAPMLGVGLASTLFAVALLASGVNSTVTATLAGQIVMEGFLRLRLPPWMRRLLTRGIAIVPVVVVTWLYGEAGTARLLVLSQVVLSMQLPFAVIPLVRFVADRGLMGALVAPAWLVRLAWVIALVIVGLNLKLLWEFALG
The following text describes a protein:
Function:
Catalyzes the phosphorylation of diacylglycerol (DAG) into phosphatidic acid. Is a key enzyme involved in the production of lipoteichoic acid by reintroducing DAG formed from the breakdown of membrane phospholipids into the phosphatidylglycerol biosynthetic pathway. Is more active toward long-chain DAG compared with short-chain DAG. Is not able to phosphorylate substrates other than DAG, such as monoacylglycerol, ceramide, undecaprenol, phosphatidylinositol, or sphingosine.
Sequence:
MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAGDATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALGIPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQLAYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGMFDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGGMLPGEFVNLYRHIHVVMPKEKAEQLDD
The following text describes a protein:
Function:
Has growth inhibitory activity.
Subcellular Localization:
Secreted.
Sequence:
LIGHPVQPHSAKKQEIAFKAPPTDGHPASCGSAEEWNQAQPDSVFSPLFQDYEFPLHSHGAPYQKNDRCPPPPQTLPDRACEVPSCRSDSECERHKRCCYNGCIYACLESVPPPPVLDWLVQPKPRWLGGNGWLLDGPEEVLQAEACSTTEDGDEPLHCPTGYECHIINPGNAAEGIPNRGQCIKLRGNSGMSHK
The following text describes a protein:
Function:
Catalyzes the synthesis of N-((2S)-2-amino-2-carboxyethyl)-L-glutamate (ACEGA) from O-phospho-L-serine and L-glutamate. Involved in the biosynthesis of L-2,3-diaminopropionic acid (L-Dap), a precursor of staphyloferrin B and antibiotics.
Sequence:
MIEKSQACHDSLLDSVGQTPMVQLHQLFPKHEVFAKLEYMNPGGSMKDRPAKYIIEHGIKHGLITENTHLIESTSGNLGIALAMIAKIKGLKLTCVVDPKISPTNLKIIKSYGANVEMVEEPDAHGGYLMTRIAKVQELLATIDDAYWINQYANELNWQSHYHGAGTEIVETIKQPIDYFVAPVSTTGSIMGMSRKIKEVHPNAQIVAVDAKGSVIFGDKPINRELPGIGASRVPEILNRSEINQVIHVDDYQSALGCRKLIDYEGIFAGGSTGSIIAAIEQLITSIEEGATIVTILPDRGDRYLDLVYSDTWLEKMKSRQGVKSE
The following text describes a protein:
Function:
Alcohol dehydrogenase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (By similarity). PatD catalyzes the conversion of neopatulin into E-ascladiol (By similarity). The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGSTLPTTYKRAFFEKQDATLTLEEVQLIEPQRGEILVKVEACGVCHSDHFAQMNLMGGGFPRVPGHEVVGRVAAVGDGETYWKIGDRTGAGWHGGHDGTCGACKKGLFQMCDNEQVNGITRDGGYAEYVLIRSEAAVRIPDHVNAAKYAPMLCAGVTVFNSIRQMNIPVGETVVIQGLGGLGHLALQYANRFGYRVVALSRGAQKEEFARKLGAHVYIDTSKEDPVAALQKLGGAALIVSTAPSPELINPLIEGLGVLGKLLILSIVGGIEVHTGLLVSERRIAIHRTNSIVRSLLTNSKVGKGKSIWSWPSGHATDSEEAIAFAELQGIDCLVEEFPLEKCNEAFGRSSSTTADRERVFLADFTGLTTTAAMMDGSVRFRAVITME
The following text describes a protein:
Function:
Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAPKPAKTSSKTAKLPTPAATPTRQPSVDTLSKPAVVDTPPTPASPAQVSAPVPPKKFAYPIPSRLSPSTINNTESLLRFIILALICGAAIGSRLFAVIRFESVIHEFDPWFNYRASKVLVNKGFYEFWNWFDPSAWYPLGRTVGTTLYPGLMVTSGLIWHALRAINMPVDIRNVCVLLAPGFSGLTAWATYLFTTEMSTPSAGLLAAAFIGIVPGYISRSVAGSYDNEAIAIFLLMSSFYSWIKAVKTGSSFWGMITALFYGWMVAAWGGYVFITNMIPLHAFVLIVMGRFNNRLYTAYSSWYVIGTIASMQVPFVEFLPIRTSEHMAALGVFGLVQLIGFVEVVRRLVPGKQFQLLLKAFVVAVFCLSFAALVTLTFSGWIAPFAGRFYSLWDTGYAKVHMPIIASVSEHQPTAWPSFYFDLEMLIFFFPAGVFWCFKELRDEQIFIIIYAVLSAYFAGVMVRLMLVITPVVCVSSAIAFSKLLEAYIDPVIPESDEEAGESQTQVVSKSKAKKMAAANANKSGFSFTGILSGKSVSGIFGLDTRFAVVSILSVFLFIFVLHCTYVTSTAYSSPSVVLASRNPDGSQNIIDDFREAYYWIRQNTAEDSVIMSWWDYGYQIAGMADRPTLVDNNTWNNTHIATVGKAMASNEDVAYPILRKHDVDYVLVIFGGLLGYSGDDINKFLWMVRISQGEWPDEVQEVNYFTQRGEYAVDDRATPTMKNSLMYKMSYYRFPELYGGHPAQDRVRGQIIPPNSVTLDTLDEAFTSENWIVRIYKVKKEDPIGRDHKAVTAWNGGKKLKKSPSASEGVKRGSGRPSM
The following text describes a protein:
Function:
Nucleotide-sugar transporter that transports UDP-rhamnose or UDP-galactose and UMP in a strict counter-exchange mode.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MFKKMSATTSKTDQKAALDIASWLFNVVTSVGIILVNKALMATYGFSFATTLTGLHFGTTTLLTTFLTWLGYIQPSQLPWPDLLKFVLFANFSIVGMNVSLMWNSVGFYQIAKLSMIPVSCLLEVMLDNVRYSRDTKLSILLVLAGVAVCTVTDVSVNLNGFLAAAIAVWSTALQQYYVHYLQRKYSLGSFNLLAHTAPVQAASLLLVGPFLDYWLTNQRVDAYNFSFVSLFFLILSCSIAVGTNLSQFICIGRFTAVSFQVLGHMKTILVLVLGFTFFGKEGLNLQVVLGMLIAILGMIWYGNASSKPGGKERRSLSIPITKSQKLSETNESDEKV
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts on the folding of rhodopsin RH1 and RH2 (but not RH3) and is required for visual transduction.
Sequence:
MAKLFELTLAVVLGLCLVTHAVAASDDKGKKDDKDKKDKDNEEEEVPKLLVTKKAWFDVEVDDEPIGRFVVGLFGEMAPITVANFAALARGNYRMDPKFGYKNTYIHRVVQDHVIQGGDITVGDGTGGKSIYGADFADETFDLSHDDKGWVSMANAGPDSNNSQFFITLQPARFLDKRHVAFGKIIEGMDIVEKIGEVDVDDFGRPKKPVLIKDCGVQHTSPYELKPKSNTEGAKKSDKSDK
The following text describes a protein:
Function:
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.
Subcellular Localization:
Nucleus.
Sequence:
MAESGRPMFAMLCANNVNRSTEAHDHLHAAGLRVCSFGAGNRVRFPGPSRDDPRIYEFFTPYETMYRELKAENAELFKRNGVLSMLERDMLTKKCPQRWQDLSSKELQALDVVLCFDDRIFEIVLEDLQLRGAPGSEPTTAWRPLHLLCLDTKDTPEHAKVGGSLALELCQAVG
The following text describes a protein:
Function:
Can convert Man(9)GlcNAc(2) and Man(8)GlcNAc(2) into N-glycans with a terminal alpha-1,6-linked Man residue in the C-branch. Functions in the formation of unique N-glycan structures that are specifically recognized by components of the endoplasmic reticulum-associated degradation (ERAD) machinery, which leads to the degradation of misfolded glycoproteins. Most likely generates N-glycan signal on misfolded glycoproteins that is subsequently recognized by OS9. Required for ERAD of the heavily glycosylated and misfolded BRI1 variants BRI1-5 and BRI1-9. Does not seem to play role in N-glycan processing of correctly folded proteins destined for secretion.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MDSNFKWLLFAILISLTFSGFVLHHGVLAESVKPDEAKQLRDEVRGMFYHAFDGYMNNAFPLDELRPLSCQGEDTLGGYALTLIDSLDTLALLGDRERFTSSVEWIGKNLQFNINKTVSVFETTIRVLGGLLSAHLIASDYATGMRIPSYNNELLVLAENLARRMLPAFDTPTGIPFGSVNLMYGVDKHESKITSTAGGGTLSLEFGVLSRLTNDPVFEQVAKNAVRGLWARRSNLDLVGAHINVFTGEWTQKDAGIGTSIDSFYEYLLKAYILFGDEEYLYIFQEAYRSAMQYLHKDPWYVEVNMDSAAIVWPVFNSLQAFWPGLQVLAGDVDPAIRTHTAFFSVWKRYGFTPEGFNLATLSVQYGQKSYPLRPELIESTYWLYKATRDPRYLDAGRDFVASLQYGAKCPCGYCHITDVELHKQEDHMESFFLAETVKYLWLLFDLAVDSDNLVDNGPYKYIFSTEGHLLPITPQISLAREHCSYFGGYCPSNSTKLEQEVLGEDSSNDDHSNDYPYHESFPVTGLIKGLCPGLTHAQKYGFSYVLPEKTDREDVNQPKPVVTSSSIVLISDQTVEKRPQEEEGFTSQSEPIMTISGGSSNDQTGQELTLLESETDDQRSYSS
The following text describes a protein:
Function:
Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
Miscellaneous:
MISCELLANEOUS: Present with 1560 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MQAKLLFTRLNFRRPSTTLRQFPLTCFLFHSKAFYSDLVTKEPLITPKRIINKTPGLNLSISERASNRLAEIYRNSKENLRISVESGGCHGFQYNLTLEPATKPDIKNDVKDKEFSDDLDDDDSKDIIYVLPEDKGRVIIDSKSLNILNNTTLTYTNELIGSSFKIINGSLKSSCGCGSSFDIEN
The following text describes a protein:
Function:
Transcriptional regulator required for survival in oxidative stress and for establishing infection in host tissues. Regulates the expression of a subset of genes involved in oxidative stress adaptation and virulence, enabling the bacteria to adapt and persist in host tissues.
Domain:
The N-terminal domain binds DNA and the C-terminal region plays a pivotal role in dimer formation.
Sequence:
MTSVKLDLDAADLRISRGSVPASTQLAEALKAQIIQQRLPRGGRLPSERELIDRSGLSRVTVRAAVGMLQRQGWLVRRQGLGTFVADPVEQELSCGVRTITEVLLSCGVTPQVDVLSHQTGPAPQRISETLGLVEVLCIRRRIRTGDQPLALVTAYLPPGVGPAVEPLLSGSADTETTYAMWERRLGVRIAQATHEIHAAGASPDVADALGLAVGSPVLVVDRTSYTNDGKPLEVVVFHHRPERYQFSVTLPRTLPGSGAGIIEKRDFA