lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Factor that activates the transcription of structural genes for phosphorus acquisition.
Subcellular Localization:
Nucleus.
Sequence:
MNSSSWSAPDHSHHPALHTAADDDFHQYLDINDMGDLSDALDFDFRDFGADHHTAPHAGRHAADHLLHPSGGEHLDTPMTGTDMSMILSPVDHAMLRHGVQQQQHHQQQQHQQHQMPTITTTAPYQNAPTALIQPSTPSEAIVNTIDAQIQFLQQQKLHAQHQQLQEQQAAFFASQQNHIVPPTPQSLELTAGSSQNYYAQSTLSDQHHSGPQKQQQPQQAIDYRYTRIKDQHDMSFTPLVSPAVTPLETHFPIDTPFAVPGAYFSPLTSPALHAQNDALGIIDQRLGMMSGSSPREMELEPPAMSQASVSPGDLARKTRKNAVKARAKSGSGIKQSPISKPIRRKTATTPMLNPQALNQLVENAAPSQERQQPLTPLIPTSSSSTAGVTDSENGSISPENLNDVVLPVEMPPPPLPKPRSAKPSPFLAPQASGSAVPINLQPGRPGIASPATPASLMKLSSPSNRNPSVVGTGSHDPMDPDHIENFELPDSINFSSAPKPAPIITTLGTPALDPLQKAAAPLQTPGLPPPPSPAVAKPLALPSAALSSPQLKPDSAHSLKRTPQLAPMGRSSKKRASVTSIQMSPALRPKISPSIKPLLPGGSAGAEDAASILLATKSNYQRILEGNTVPGVSYPSELSTNLTSKRTSHKIAEQGRRNRINSALQEIATLLPKAPAKEGGDGDGDGHSSSGGGGGSGGADREDKREKDKDKAGGGIPNSKASTVEMAIEYIKQLQKEVADANKRAEEAERKLVEMKMQGGAATGSGSSVGDAGDLGTPTTEANPVVDEDLKSGGGDAMDE
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
Sequence:
MAVRVPATLHRKRWRHHHDAAPLPIPIASLTGVAASDDNWCHCTGRFLGDCVVVTDLKEMTMLYTNGFFGKGTMSKCGPVTDTFNQEKRQPSHLQLPLSSTLFQSRKRARVEETSTADDGMEGGTLQPGQLEQVDALWNDPNGTDHYRTEHSQTPVTQDWEGGDSSCWTMHGQSGQSGQSSSPVREEPEATSVLSFSTPKQSTSQREHSHNYFAGRKPVFISGCEQKCETETGHSDAGLRNSLPGQENKGVIPKDCASQKYHISGTLDQNRVGESLQLSLEEAFFLSYGLGCLSVVDESGCLMTLTDMWQSFTQTQHNFLPNYIVYHYLRSKGWVPRAGVKYGAPWVLYWKGPSFYHSSYSVVVQTVSGDSLKPSPGLSCCRSWLLLAGMDRITQHVGKEVVLCFVVRPADMTEEEQTSPSCISRFRVQEVVMKRWVSSQEREEHQDDH
The following text describes a protein:
Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus, nucleolus.
Sequence:
MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNTTVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVNLKKKSYLNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK
The following text describes a protein:
Function:
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus (By similarity). Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP (By similarity).
Miscellaneous:
MISCELLANEOUS: The VP6 trimer contains a zinc ion located at the center of the molecule. The zinc ion is not essential for either trimerization or transcription activity of the DLP. Zinc-depleted VP6 has an increased sensitivity to proteases.
Subcellular Localization:
Virion. Note=Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Sequence:
MDVLYSLSKTLKDARDKIVEGTLYSNVSDLIQQFNQMIITMNGNEFQTGGIGNLPIRNWNFDFGLLGTTLLNLDANYVETARNTIDYFVDFVDNVCMDEMVRESQRNGIAPQSDSLRKLSGIKFKRINFDNSSEYIENWNLQNRRQRTGFTFHKPNIFPYSASFTLNRSQPAHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANTQQFEHIVQLRRVLTTATITLLPDAERFSFPRVINSADGATTWYFNPVILRPNNVEVEFLLNGQIINTYQARFGTIIARNFDTIRLSFQLMRPPNMTPAVAALFPNAQPFEHQATVGLTLRIESAVCESVLADASETMLANVTSVRQEYAIPVGPVFPPGMNWTDLITNYSPSREDNLQRVFTVASIRSMLVK
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MSQVAVTKEDQALLNEFSVLHARHAVMEMDQKKLKTQLEDVVDATNECELLDEDDVDEIPMYKVGDAFFKLPLDKLNEHLEQDQEQLNKAVEQLDEKMEEDMVRIKELKTRLYSKFHDQINLD
The following text describes a protein:
Function:
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
Sequence:
MAGLSHPSVFGRATHAVVRAPPESLCRHALRRSQGEEVDFARAERQHQLYVGVLGSKLGLQVVQLPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADSLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDMAANCIYLNIPSKGHVLLHRTPEEYPESAKVYEKLKDHLLIPVSNSEMEKVDGLLTCCSVFINKKTDS
The following text describes a protein:
Function:
Involved in the biosynthesis of the coenzyme M (2-mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde.
Sequence:
MYPKRIDIIKKIVENVGEKEIIVSNIGIPSKELYYVKDRERNFYMLGSMGLASSIGLGLALNCEDKVIVIDGDGSILMNLGSLSTIGYMNPKNYILVIIDNSAYGSTGNQKTHTGKNTNLEEIAKGCGLDTITTESLEEFEKEFKNALNEEKCKVIIAKTIPYNEKCSNIEIPPVVLKYRFMEAIKRS
The following text describes a protein:
Function:
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Subcellular Localization:
Nucleus.
Sequence:
MPKYYCDYCDTFLTHDSPSVRKTHNNGRKHKENVRFYYQKWMEEQAQTLIDQTTAAFQSKPNSQMPPNAPPGLMPPPGMLPPPGGMPPGRMPPQGLPFPPPGPIPPPPGAGGMRPPHGQMHMGGPRPQMGRPPMSLRS
The following text describes a protein:
Function:
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
Subcellular Localization:
Secreted.
Sequence:
MKLDSFGVLVAIVLFCEQHVFAFQSGQVLSALPRTSQQAQILQNLTTTYQIVLWQPVTAEFIVKTKQVHFFVNASDVSNVKAHLNESGVPFRVLMGDVEELIRQQTSDDLLSPRASSSYYEHYHSLNEIYSWIETITERHPDLVEKIHIGSSYEKYPLYVLKISRKEQTAKHAMWIDCGIHAREWISPAFCLWFTGYVTHSHGKENQYSDLLRHMDFYVMPVVNVDGYDFTWKKNRMWRKNRSFHGNNPCIGTDLNRNFASKHWCEEGASSFSCAEIYCGPYPESEPEVKAVADFLRRNINHIKAYISIHSYSQKIVFPYSYNRSKSKDHEELSLLASEAVHAIEIASKNTIYTHGSGSESLSGGGDGRTGTENKHVTRCQPTMTARPNSAPCLFCIANLAPGGSDDWIHDLGIKYSFTIELRDTGRYGFLLPARYIRPTCTEALAAVSKIAWHVVRNV
The following text describes a protein:
Function:
Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of a MutL heterodimer with MLH1, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Plays a role in the repair of heteroduplex sites present in meiotic recombination intermediates and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates.
Miscellaneous:
MISCELLANEOUS: Present with 72 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTIHQLSPESQWKIVSSSFIYGPVAAVRELLDNSIDSGAKKVFIDVDSTTGGCEYISVKDDGSGVDIIDRPSMCLEYTTSKMSSLGDISILTTLGFRGEALFLLSNLCNQKGSMQVETKTADDVIGEKWLVDSKGGITNGKRYKVSCPVGTTVILRKLLGGLRARYLEISSRPRKTFDELIYLINHYSLIHRNIRFYFSLVSLQKNGAIERKQMQETLDPKISRARSLSLLARLKKPVPLNFIVEENFVIDEKINLDLILPRMVPESDVINIKRRFKFLSVNERALSLNLETGKTISKLLSSIYRDFSLLDPMVWFINLNCDTKLLDVNIEPEKNDVMIKSFEVIFKKIENKLKLLLEERIGIETNMLGDKHVQPSINEKTSPALVIPTPDAENEISKGCGAVSGKDKTDIPQKNSDLIVPTFYDEANLENTTIVAATPSPTKFSEDKALDEQTQLTISSYRSSSSGSMASEDSTNWRHNFQQELSENSEVAGAGSSTLPSSLTYNYIETIPENEDLELSKDASISNPFMITKIRNVNKKLSENLLEAKRTSCGDANKRGMPNERQLSNTEKKELIKLQQTYGKRNNTVDMTIPRNSKKKVTDNYIKKASCMHKTRPKLMHFSEYTNNYVYTLKNEKIVKHDSDNFAKETLWLRSRDDATSPSSSLLQALRAHVKKPGHIEATTNEWCLFTPDSP
The following text describes a protein:
Function:
DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Acts as a transcriptional coactivator. Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification. Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (By similarity). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (By similarity). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression. Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (By similarity). Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. May function as a tumor suppressor (By similarity).
Subcellular Localization:
Nucleus. Note=Colocalizes with PITX2 in the nucleus at subnuclear chromatin regions. Colocalizes with CBX5 to a heterochromatin-rich region of the nucleus (By similarity). Colocalizes with GLI2 in the nucleus.
Sequence:
MQARYSVSSPNSLGVVPYLGGEQSYYRAAAAAAGGGYTAMPAPMSVYSHPAHAEQYPGSMARAYGPYTPQPQPKDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAVKDKEEKGRLHLQEPPPPQAGRQPAPAPPEQAEGSAPGPQPPPVRIQDIKTENGTCPSPPQPLSPAAALGSGSAATVPKIESPDSSSSSLSSGSSPPGSLPSARPLSLDAAEPAPPPQPAPPPHHSQGFSVDNIMTSLRGSPQGSAAELGSGLLASAAASSRAGIAPPLALGAYSPGQSSLYSSPCSQSSSAGSSGGGGGGGGGGGGSSSAAGTGGAATYHCNLQAMSLYAAGERGGHLQGPAGGAGSAAVDDPLPDYSLPPATSSSSSSLSHGGGGQEASHHPASHQGRLTSWYLNQAGGDLGHLASAAAAAAAAGYPGQQQNFHSVREMFESQRIGLNNSPVNGNSSCQMAFPASQSLYRTSGAFVYDCSKF
The following text describes a protein:
Function:
Binds covalently through a thioester bond to the pathogen surface resulting in pathogen clearance.
Sequence:
MRLQGADMGAIPVLILVTACLLCQTSAQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTDFKTVELRPFSTQLLHFEIPALRTDRYRLTAEGLGGVQFTNETQLHFESKQHTVLVQTDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGTWSIVVDVSDQEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIVGEATLSIYPTFFGSLQPFVNDLITRKVVPIDGNAYFEFDIENELHLKQDYERQYLLDALVEEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATARIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRDEFHSIIVDYQGVISEVGKIPSKHLHSKNYITAKVLNDRPTVNQEISVVVRSFAPIKYFMYQVVGRGDIILSRNVDVAPGTFHTIKFLASFAMMPRANLLVYTVIDGEFVYDEQVIQLEENLLNAVQVDAPIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRSYELSDVNTPMGSPGKESGVITMSNTDYFIEKEAESNPALDREVSTGPEEDKLTTVRKTDIGPAHKIEVNTLPPGKGRYAFSYTPKPFWHNPRVHVMRDPADTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRVGPLLVKAMAASSQAGDTVEQNLLVEHPGAMERINRGFLFELNSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFERFGDDGISLTAFVTLALMENVDLYPEYRNNINKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWNKTAPAGEQQSPWYNATRSVNIEISAYAALALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAERFSSQGNNLQIGFHYGEGAETIINVNAENSLALQTVELPNNLKNLSVSATGRGMALAQVSYTYNTNVTSAWPRFVLDPTVNRNSHADYLHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERIKKVETQNRNTKVVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSNICDICEHANCGDLCEKAEKRESKRPDDYTAIAGHSSGSRHTAIPLASVVMVLSMLLKTLSC
The following text describes a protein:
Function:
Involved in signal transduction through the Wnt pathway.
Subcellular Localization:
Nucleus.
Sequence:
MTHNLGMAPYRLPGPAGGLCPPDFKPPPPTDIISAPSNPKKRRKTSSAANSAAAVAAAAAAAAAANSMQQQQAPPTPQDLLPPPPMGGFGDTIIASNPFDDSPQVSAMSSSAAAAMAAMNQMGGGPGGGHFGGGGPGGHPHWEDRMGMGGGPPPPPHMHPHMHPHHPGGPMGHPHGPHPHMGGPPPMRGMSPMHPHQMGPGPGVGLPPHMNHGRPGGPGGPGGPVPMGSPMGGIAGMGGMSPMGGMGGPSISPHHMGMGGLSPMGGGPNGPNPRAMQGSPMGGPGQNSPMNSLPMGSPMGNPIGSPLGPPSGPGPGNPGNTGGPQQQQQQPPQPPMNNGQMGPPPLHSPLGNGPTGHGSHMPGGPIPGPGPGPGGLVGPGGISPAHGNNPGGSGNNMLGGNPGGGNSNNNGSNTSNASNNNQNPHLSPAAGRLGVPTSMQSNGPSVSSVASSSVPSPATPTLTPTSTATSMSTSVPTSSPAPPAMSPHHSLNSAGPSPGMPNSGPSPLQSPAGPNGPNNNNSNNNNGPMMGQMIPNAVPMQHQQHMGGGPPGHGPGPMPGMGMNQMLPPQQPSHLGPPHPNMMNHPHHPHHHPGGPPPHMMGGPGMHGGPAGMPPHMGGGPNPHMMGGPHGNAGPHMGHGHMGGVPGPGPGPGGMNGPPHPHMSPHHGHPHHHHNPMGGPGPNMFGGGGGGPMGPGGPMGNMGPMGGGPMGGPMGVGPKPMTMGGGKMYPPGQPMVFNPQNPNAPPIYPCGMCHKEVNDNDEAVFCESGCNFFFHRTCVGLTEAAFQMLNKEVFAEWCCDKCVSSKHIPMVKFKC
The following text describes a protein:
Function:
Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2.
Subcellular Localization:
Nucleus.
Sequence:
MATSNHMETIELSEAIKTILDESNSPERKNNSVFSITTPRSRKAKSPKCLTARFSVGQNTTPNSRSASKKGSDTPLSRKSSILQRSIGGDSGGGSSQRKRRHAQEVIILRPPKKRMGGSTPRVTSTSKPTPSSQSTPKPTSITPSLKNSFQSTPVSSQSRSRINPHHISNVNVKTEEKQLKDALFVTPDLSMTPKQVSLLGGENLSPKERENLLLQSRYLRMMEQQGLGLGGFEAGGALREDSGIAEQITPGGLSLNIADQTSRISLVARGNQDDSLTNITWLRRMSAPDLDPITLPHIKSQDPHKERPPYSYSSLIQFAISSAPEGKLTLRDVYFWIETHFPYFRTAKLGWKNSIRHNLSLHKIFVREAPSGPGQPAFWTLRPGTVVRLPERKVIVHEEMAMPAGIPECFAPEGSFDMAAMANLQMQALVGDPSRMPMLSAQDGTMINRAPVLTSTPMVSRPIIKGSKRVPPILPKGTPPYALVPLPIYFTTDPKTGQLVPANRDNAPPGSDMTSLILPRPTEDNTPKSTGPKVELNSSDSTPLTRMEQAGGAFGRFTLDSGYGSTDSSVGDDGRASLVRDSKLLKNMAQAKCNSEKENSLSSEFGLGLDVDDDLLKTPPKSACPDWLSPIRGFSPVPDSGFSIKDMDFNFTPFKTGFTPNNRVGHSNTPRHHMLSPVNRNIPSTSGGMRSSRKSRMMTPKRYVEGKDSGKDSMLNSSFEKMFGDVNFDVDPDNIDVGNMSWLLNSPPPVK
The following text describes a protein:
Function:
As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MALSRAKPDELPRDAVVITEDQALKYQWKIITSWDKIGEVWSLRYTPGILSALAAGTGAYINNHYRTKLRLGGHGRLSTYLPIVAVPAIFTMLAHKFFIQRPILLNPLGECPVCIQMRSAAFQTSLGIVYPTILAPFAAFLFATRCYTYRIPSITENPREVFLLWRKFTRPIVPALGTLIGLQALLTMFLTGQEDKQNFKLMLRMREIEHQVEEEHLPQRMDF
The following text describes a protein:
Function:
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MADVYELFLTCPKGLESLLLEEAQGLGLDEARAQVSAVRGQGSLEVAYRLCLWSRLANRVLLVLARFPVENAESMYMAVHAVNWEDHLDAGGTLAVEFSGKGSGIDNTHFGALKVKDAIVDNLRERSGRRPSVDKVNPDVRVHLHLDRGQATLSLDLSGHSLHQRGYRLQQGAAPLKENLAAAVLIRAGWPKIAAEGGALADPMCGVGTFLVEAALMAADIAPNLKRERWGFSSWLGHVPALWRKLHEEAQQRAAAGLARPPLWIRGYEADPRLIQPACNNIERAGVADWVKIYQGELATFEPRPDKGQTGLVICNPPYGERLGDEASLLYLYQNLGERLRQSCIGWSAGVFTGAPELGKRMGIRSHKQYAFWNGALACKLLMIQVEPRQFVTGERGERNDEGLARAPSEPARLSEGGQMFANRLQKNLRQLGKWARRDKIECYRLYDADMPEYALAVDIYGDWVHVQEYAAPKSIDPAKAQARLFDALAAIPQTLGVAQERVVVKRRERQAGKKQYERQSSEGKFLEVGEGDVRLLVNLTDYLDTGLFLDHRPMRLRIQKEAAGKRFLNLFCYTATATVHAARGGARSTTSVDLSKTYLDWARRNLSLNGFSDKQRLVHGDVMEWLREDDGQYELIFIDPPTFSNSKRMEGVFDVQRDHVELLDLAMARLAPGGVLYFSNNFRKFELDESVQARYAVEEITGETLDPDFARNPKIHRAWRITVR
The following text describes a protein:
Function:
Regulates drug efflux through modulation of ABCB1 localization and activity.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MTVGARLRSKAESSLLRRGPRGRGRTEGDEEAAAILEHLEYADEAEAAAESGTSAADERGPGTRGARRVHFALLPERYEPLEEPAPSEQPRKRYRRKLKKYGKNVGKVIIKGCRYVVIGLQGFAAAYSAPFAVATSVVSFVR
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MDSDEEFIDNSLAVGDIVYDEAQIAQQQQEYAAQLKLASTAIPTVVKDFIQYFHRCLSDNSVYELHGCYENSFGKLTDKFYKNSHWPHPVAQVAPLVKNDPVFLYFYSELYYRHLYAKLTPTPLERFESYSNYCNLFNYILNSDGPVDLELPTSWAWGIVDEFIYQYNSYWMTKEAHNSDGVAPDTWGTYSVLNVLYSLSEKTKIREQLRAIKAGLDPMDVAGPYGSRPLYKMLGYFCVIGLLRVHTLLGDFTLALKTMESIELTKKALFARVAPAHFATYYYVGICYVMTRRYADAIRCFSHVLTYMARTKNVQGPRYDAKRSEQMYALLAICVVLSPARLDDSIHVALRDRYGDQMAAMQRGDLKLFEELFTFAAPKFIQPGDVHGGDPLKHHLKIFMVDVTNTLSTANLKSYLNLYATMDLGKLASFLDTDAEDLRSQLVTLKMKNRQLRWTEGELADGTYQHCSELDIALENDLIHVAEAKGGRKFADWFIRNTVKNYSVQDYIVNGDKKDKEKKN
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFKSVDPNQTLKISNLQTNKQFHTDFDSELQDLFDYTVRSHPVPKREIWNDNLEEEFALIREIVDDYPYIAMDTEFFGVVIRPLAQFKNINDYNYVTLKDNVDMLKSIQLGLTFSDEDGNLPTYGTDKPCIWQFNFHRFNVNEDIFANDSIEMLRQRGIDFKNNSVIGI
The following text describes a protein:
Function:
Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via muramidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi3 that specifically interacts with and inactivates cognate toxin.
Subcellular Localization:
Host membrane. Secreted. Note=Delivered to the target cell periplasm by the H1 type VI (H1-T6SS) secretion system.
Sequence:
MTATSDLIESLISYSWDDWQVTRQEARRVIAAIRNDNVPDATIAALDKSGSLIKLFQRVGPPELARSLIASIAGRTTMQRYQARNALIRSLINNPLGTQTDNWIYFPTITFFDICADLADAAGRLGFAAAGATGVASQAIQGPFSGVGATGVNPTDLPSIAFGDQLKLLNKDPATVTKYSNPLGDLGAYLSQLSPQDKLNQAQTLVGQPISTLFPDAYPGNPPSRAKVMSAAARKYDLTPQLIGAIILAEQRDQTRDEDAKDYQAAVSIKSANTSIGLGQVVVSTAIKYELFTDLLGQPVRRGLSRKAVATLLASDEFNIFATARYIRYVANLASQQDLRKLPKTRGAFPSIDLRAYAGNPRNWPRDNVRALASEYTSRPWDDNLSPGWPMFVDDAYATFLDPGMRFP
The following text describes a protein:
Function:
Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. Required for binding of cwo to the E box regions in the promoters of target genes of the transcriptional activator Clock, probably by binding to Clock-cycle heterodimers, reducing their affinity for E box binding and allowing cwo to bind instead.
Subcellular Localization:
Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytosol. Note=Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization. In photoreceptors, widely expressed throughout the cytosol during the day and then in the evening localizes to the nuclei.
Domain:
Mutations in the PAS domain result in longer circadian rhythms and courtship song (PERL mutation) or makes the flies arrhythmic (PER01 mutation).
Sequence:
MEGGESTESTHNTKVSDSAYSNSCSNSQSQRSGSSKSRLSGSHSSGSSGYGGKPSTQASSSDMIIKRNKDKSRKKKKNKGAGQGAGQAQTLISASTSLEGRDEEKPRPSGTGCVEQQICRELQDQQHGEDHSEPQAIEQLQQEEEEDQSGSESEADRVEGVAKSEAAQSFPIPSPLSVTIVPPSMGGCGGVGHAAGLDSGLAKFDKTWEAGPGKLESMTGVGAAAAGTGQRGERVKEDSFCCVISMHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIPIAESRGSVPKDAKSTFCVMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMVSNGTNMLLVICATPIKSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPKQCNVFEAAPTCKLKISEEAQSRNTRIKEDIVKRLAETVSRPSDTVKQEVSRRCQALASFMETLMDEVSRADLKLELPHENELTVSERDSVMLGEISPHHDYYDSKSSTETPPSYNQLNYNENLLRFFNSKPVTAPAELDPPKTEPPEPRGTCVSGASGPMSPVHEGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGNGTNSGTGTGTASSSKGGTAAIPPVTLTESLLNKHNDEMEKFMLKKHRESRGRTGEKSKKSANDTLKMLEYSGPGHGIKRGGSHSWEGEANKPKQQLTLGTDAIKGAAGSAGGAVGTGGVGSGGAGVAGGGGSGTGVAGTPEGRATTTSGTGTPGGAGGGGGAGAAAAAGASSSVGSSTPGPSSYPTCTQNINLWPPFSVGITPPVHSTHTAMAQSSFSSAGLFPTFYYIPASLTPTSPTRSPRMHKHPHKGGTDMPTTSQQAAAAAAQAMPLQYMAGVMYPHPSLFYTHPAAAAATAMMYQPMPFPGMANALQIPERPLGSQSAYNKSVYTTTPASMTKKVPGAFHSVTTPAQVQRPSSQSASVKTEPGSSAAVSDPCKKEVPDSSPIPSVMGDYNSDPPCSSSNPANNKKYTDSNGNSDDMDGSSFSSFYSSFIKTTDGSESPPDTEKDPKHRKLKSMSTSESKIMEHPEEDQTQHGDG