lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in ciliogenesis. It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length. Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MAAAPSALLPLPPLPSLCAYRLQSRSRPSAPETDDSRGGGAMRGEKNYCCRGAAGDHGSCPPTPSPLASTLLMPAEAISSSWSGPGGGLSGGDEEETRLLQQLRTAPDPSEAFQALQAALPRRGGRLGFPRRKEALYRALGRVLVEGGSDEKRLCLQFLSDVLRGQGELGQLEEAFSLALLPQLVVSLREENPALRKDALQILHICLKRSSGQVLRTLIQQGLESTDARLRASTALLFPILLTPEDLLLDLDLTEVIISLARKLGGQEIEEESETAFSALQQIGERLGQERFQSYISRLPSALRRHYNRRLESQFGSQVPYYLELEASGFPEDPLPCAGSLSNSNLKFGIIPQELHSRLLDQEDYKNRTQAVEELKQVMGRFNPSSTSHPSLVSFISLLYNLLDDSNFKVVHGTLQVLHLLVIRLGEQVQQFLGPVIAASVKVLADNKLVIKQEYMKIFLKLMKEVGPQQVLCLLLEHLKHKHSRVREEVVNICICSLLTYPSEDFDLSKLSFDLAPALVDSKRRVRQAALEAFAVLASSMGSGKTSILFKAVDTVELQDNGDGVMNAVQARLARKTLPKLTEQGFVEYAVLIPSSAQGRSSHLAHGADADWLLAGNRTQSAHCHCGDHTRDSMQTYGSYSPTICTRRVLSAGKGKNKLPWENEQPGVTGENHTSSSKDIEQFSAYDFIPSPKLKPSQGMPVNDDLCFSRKRASRTVFQNSREFNPDSLPICSAGTSGTHQTNLSGKCGQLGFSQICGKTGSVDSDLQYLGTTNSHQDKGENSQEKPPQVQLTPALVRSPSSRRGLNGTRPVPPIPRGLSLLPDKAGLSTVGPKKKEPDDIWKSEKDNLTVDLSELNIRDKDLDQEEMQSSLRSLRNSAAKKRAKLSGSTSDLESPDSAMKLDLTVDSPSRSSSPNTSSYSESGVYSQESLTSSLSTTPQGKRIMSDIFPTFGSKPCPTRLSSAKNKNSQVAEHSPSTGTTTSSVSIIGHRMNYGFGCGDFEEDRSHDISPSALKIQNKEQPRHYKHTKASTGSSSNFHQISSFDFMSTNTLSEDSVVVVGKGVFGNPIPAPATCSQSVITSVENGVSFSVKNTEPPSGIYGRAVQQSIPSYVDSENEKDIKVSISKSTYDKMRQKRKEEKELFDIKDSERKEQNPWERMKYTGNEKMAPQNEASPGAIPQYKERMPSVTHSPEIMDSSELRPFSKPEVALTEALRLLADEDWEKKIEGLNFIRCLAAFHSEILNTKLHETNFAVVQEVKNLRSGVSRAAVVCLSDLFTHLKKSMDQELDNTVKVLLQKSGESNTFIREDVDKALRAMITNVTPARAVVSLINGGQSHLHIAVRRCAAQHLSDVVEFMEPERVLSGTKDMADRILPAAAKFAQDSSPETRYYGRKMLFLMMCHPNFDKMLEKYVPSKDLPYIKESVKSLRQKGLGEIPLDTPSAKGRRSHTGSVGNTRSSSVSRDAFNSAEREVTEIREITRKSVPRNSLESAEYIKVITGLLNAKDFRDRINGIKQLLSDTENNQELVVGNIVKIFDAFKSRLHDSNSKVNLVALETMHKMIPLLRDNLSPIINMLIPAIVDNNLNSKNPGIYAAATNVVQALSQHVDNYLLLQPFCTKAQFLNGKAKQDMTEKLADIVMELYQRKPHATEQKVLVVLWHLLGNMTNSGSLPGAGGNIRTATAKLSKALFTQMGQNLLNQAASQPSHIKKSLEELLDMTI
The following text describes a protein:
Function:
Plays an essential role in chain termination during de novo fatty acid synthesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MSLHLHYRLCQLLKNRRVETNQWSDVVMTEEEGIQFLMVDARHRSFAVKTIMHIEIYRYPAWGDVVEIETWCQSEGRIGTRRDWILKDIANAEVTGCATRLAFPVEENNRSLKKIPTLEDLAKYSIIGLKPRRADLDMNHHVNNFTYIGWILEVSVIIRRECQQDDVVDSLTTSKNGSATSGTQSHNDSQFLSGDGQEINCGTTLWRKKPSR
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLLSVLLQATAAAVGVSKLGAAIGAGLAVIGAGLGIGKIGGSAMEAIARQPEASGDIRMNMIIAAALIEGVALLAVVVCLLVFFL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
MSSQQQQKEQDGELANGAKKSRALAIIDGVLKQEQRGQREETRQAKGALVAEVQAVEEPQINIRMAISPLHCHACVLPLKPPIFKVSCSCSSSLFEAKICSCWIDLILETLAFCFGSQCEAGHVVCGACRGSHVQVCANAGAGAGTYVHCAELDRIVHDARVPCAYEKYGCTSWVVYYEALGHQRSCRFAPCCLCPDPGSGCGRFTSPASLAEHFIHHGWHVTEVDYAKPCKLAVPGHQVKQVQVGKADGCVFLMLSCALGAATAVSLVCVRAQVAGNKENVAMVTFLVASTDLVGGYPAIDQGMFWGFRRRCCTTSPASRP
The following text describes a protein:
Function:
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
Subcellular Localization:
Cytoplasm, P-body. Nucleus.
Sequence:
MNPRQAQCIPEGILDDLASRFIINIPEEERRDPIRLCFQIELAFWFYLDFHCPEDPALRPCTMREFTQMVFQHVPSLRDHLPNTDSIIERWKEYKMAVPTYGAIVLDETLEYVLLVQAYWARASWGFPKGKVNEGEEPQACAVREVLEETGFDISPFLNPVEYIERQVFDTQVRLYLVVGVPRDTAFSPRTRKEIKSVDWFSIADLPSHKRDQAPRATLGLNANAFFMVMPFVKPLRKWIFNSRQRRSQRQTAGVPHCITDAEKLKQKQQEYFASLYRSELLDALRLKGDGDAQQAPAAADLPRAEGLPGNVVPAFSAPSWTNFTLDKKALMACLCPKVPQC
The following text describes a protein:
Function:
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MWSIKSEDKDLIEKAKQFMEKYYRTFDANRADLVNLFREESVLAFEGQQIKGKEAILAKLTSIPECHNEIANFNCLRHRTLGSMLVWV
The following text describes a protein:
Function:
Integrase from the cryptic lambdoid prophage DLP12. Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.
Miscellaneous:
MISCELLANEOUS: Encoded by the cryptic lambdoid prophage DLP12.
Sequence:
MSLFRRNEIWYASYSLPGGKRIKESLGTKDKRQAQELHDKRKAELWRVEKLGDLPDVTFEEACLRWLEEKADKKSLDSDKSRIEFWLEHFEGIRLKDISEAKIYSAVSRMHNRKTKEIWKQKVQAAIRKGKELPVYEPKPVSTQTKAKHLAMIKAILRAAERDWKWLEKAPVIKIPAVRNKRVRWLEKEEAKRLIDECPEPLKSVVKFALATGLRKSNIINLEWQQIDMQRRVAWVNPEESKSNRAIGVALNDTACKVLRDQIGKHHKWVFVHTKAAKRADGTSTPAVRKMRIDSKTSWLSACRRAGIEDFRFHDLRHTWASWLIQSGVPLSVLQEMGGWESIEMVRRYAHLAPNHLTEHARKIDDIFGDNVPNMSHSEIMEDIKKA
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that accepts ubiquitin from E2 ubiquitin-conjugating enzymes, such as ubc-18, in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ify-1 and cyb-1 targeting them for degradation in post-meiotic embryos.
Sequence:
MIKSLNERDNFLNRLREMEHKREKDEKQEKAARKVQKFWRGHRVQHNQRLLFRAEFDAVSDRQRGLEETIKMAQLLVNFYETNKDEERLVMTLSELVKLKTSDKEFEKRIRETQRLLLARCCIKFLKNATENTIFFHIFRYLEDYVTCHSKLFEASSKLGLFNAEFHLLEALIGKPTGKTVERASLNPRILQLLTRIFETFVNPSRSTSVSVNVANRLLKTICVNITDLNFSNYILYYIKDHIKPTSPNFTNLFEAMKSVDILNNWKVRPEIAETASLRLQSIFVSQIVHVSNTQSEDVKQYFNSLAVFLEHHSKIMRSLNVKEDLSEFGRLRTSVNNHLKQYCEEMLISNEFRRAACIYANLPGVQVETIISLRKYFSQFLDLLAASNTFVEALYAFIARLCPNGEFDPIDAKSPKVNALELFCNCLNKRVSSVADSDFVPTDIFVDFDHTVEFLRDVSIKLIHLMFPTMARGDLYSGNLKEKMYKAETDWKDVTESVFSILGAIYQKDIRLKYFPEEFWTNHGREVLSGIGEHRRMPRRRMPNGRLQIERTMDTEFVERLAAIYEMDSDSENDDEDEDNNLPAVLRRAICVMKHIPFIVPFMDRVKLFTRLLNQDKEKHYTSTFGMGFNGPSVTVRRDQVYMDAFETFAPKMQGDKVNDLKSMVRVKMVNWAGMNESGIDGGGIFREFLSELLKTAFNVERGFFTFTESKLLYPNPTAPFLLGVDCLAHFQFIGRMIGKLIYERQLQEVRFAEFFIAQIFETDKNKDVDLQHMKSFDPIIFKHLKALQKMNNRELDELQLDFSVVTSDMGLVRNVNLKPNGSKFRVTVENVHEYVRLYVNYHLKQRIASMVDAVRKGISEIISIEWMRMFAPHELQIMIAGYEEVFTAKELRKFCELRFAAGTQDINYEEMFWDVIDKLSNDDKKALLKFVTGCSRAPVDGFKSIQPRMGVLVIPSSDDELPTSATCMNMLRIPKYSNRTKLEEKLRYAINSGAGFELA
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MPELFQATQVYTPRTIQLWKSLLNWLAFFFQIFLQILKGNSSLLSSSPQFKPLPDVELLEEEEEAEAAPSSVALSTLQITTGNVPTSLEEERSQRLTVVLDLDDTLICAYETSSMPTMMRTQATEAGLKWFELECISSDKEYDGKPKINYVTVFERPGLHEFLKQLSKFANLVLFTAGLEGYARPLVDKIDPENWFSHRLYRPSTISTRGPRIKGMKIEEAVALWT
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Miscellaneous:
MISCELLANEOUS: The E2 component contains covalently-bound lipoyl cofactors and it participates in the generation of acetyl groups from hydroxyethyl-thiamine pyrophosphate-E1 and their transfer to coenzyme A.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MIVPVLSRQALRHASVARVALPSLTRWYASYPPHTVVKMPALSPTMTSGGIGAWQKKPGDKIEPGEVLVEIETDKAQMDFEFQEEGVLAKILKDSGEKDVAVGNPIAILVEEGTDVNAFKDFTLKDAGGETSPAVPKDEPKNESTASAPTPAPTPAPEPENTSFTGRFQTALEREPNALPAAKRLAREKGIDLRNVKGSGPGGKITEEDVKKALASAPAAGAAAAAYTDVPISGMRKTIAARLKESVTENPHFFVSTNLSVSKLLKLRQALNSSADGRYKLSVNDFLIKAMGIASKRVPTVNSSWRDGVIRQFETVDVSVAVATPNGLITPIVKGVEGKGLESISAAVKELAKKARDGKLKPEEYQGGSISISNMGMNPAVQSFTAIINPPQAAILAVGAPQKVAVPVENEDGTTGVSWDEQIIVTASFDHKVVDGAVGAEWIRELKKVIENPLELLL
The following text describes a protein:
Function:
Mitochondrial helicase involved in mtDNA replication and repair. Might have a role in mtDNA repair. Has DNA strand separation activity needed to form a processive replication fork for leading strand synthesis which is catalyzed by the formation of a replisome complex with POLG and mtSDB. Preferentially unwinds DNA substrates with pre-existing 5'-and 3'- single-stranded tails but is also active on a 5'- flap substrate. Can dissociate the invading strand of immobile or mobile D-loop DNA structures irrespective of the single strand polarity of the third strand. In addition to its DNA strand separation activity, also has DNA strand annealing, DNA strand-exchange and DNA branch migration activities.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MLRLWVKRVQAVVIQQLIPARGYLLTTCLRKQADLKLARSPRKSIHVPGEPIRRHFKKGLLTALDHGFLQPVTMTEIRQYLRSKNVSFHDGYSCLHVPSPFTPEQDTCLFIDKTTGRFLCKATLLEGSWEDFQDSMELLHKEGCSHLSPEILAGYLVDSDSDSAEDQLKDSEVRRIWDRAVWFSDLGEEESHQIKAMFNITKIANNTLKKFGVKCFQPTKSLVFPWYNPRDSSLNGLKLLSAECNKQKVHYVETTYPRPARYYNLFGLCVSGKKETEVVITSREVDCLAIHQSTGVTTIALPRGASCLPPVLLPYLEQFKRIVLWLGDDLRSWEASKLFARKLNMKRCSLIRPGDKQPSPLHAFNDGLNIGKILKASLPASHKSIISFRQLREEVFGQLENADQVAGVKWNRFPELNKLLKGHRRGELTVFTGPTGSGKTTFISEYALDLCIQGINTLWGSFELNNVRLAKIMLTQFALQRLEEQLDKYDEWADKFEDLPLCFMTFHGQQNIKAVMDTMQHAVYMYDITHVIIDNLQFMMGQENIYSDRFAAQDYMVGAFRKFATVNNCHVTVVIHPRKEDDDKELQTSSIFGSAKASQEADNVLILQDRKLVTGQGKRHLQVAKNRFDGEVGVFSLEFNKPCLSFASSKGKQKFKKLNKDAETPNSKSSEETPAKNKK
The following text describes a protein:
Function:
May play a role in protein folding in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MAWRLALPLLLFYSPILLCSSQVQDNDPSKLFKSASEMMSLRKYDGALGLLNAILELDPNHSEAYRQRATVLRHRCRHKEAESDYNKFLELKPGTASVEKELAQLLQAQNALESAYTQSDAGEFSKVLEYVNKIVLVFSPGCLKAKLLKAKALLALKDYSNVISETGFILKEDEDNLDALLLRGRAYYYLADHDVANRHYQKGLRLDPEHSELKKAYFGLKKLLKKTKSAEENAAKSKFRVAVEDYKAALAMDPDHTLYNVQLHLGLCKTLVKLGRGKEAISTCTEALSIDEELVEALSQRGEAKLLTEDWEGAVEDLKEAAQKSPQDMAIREALMKAERQLKLSKRKDWYKILGISKTASAADIKRAYKRLALQWHPDKNVENREEAENMFREIASAYEVLSDEDKRVRYDRGEDLEEMGMGGGGGGGFDPFGGGGGQQYTFHHGGGFPGGFQFNFG
The following text describes a protein:
Function:
Component of the RAVE complex, which is required for stable assembly of the vacuolar ATPase complex V-ATPase under many conditions. Required for transport between the early endosome and the late endosome/prevacuolar compartment (PVC), suggesting that assembly of vacuolar ATPase at the early endosome is required for transport from the early endosome to the PVC.
Miscellaneous:
MISCELLANEOUS: Present with 149 molecules/cell in log phase SD medium.
Subcellular Localization:
Endomembrane system. Note=Probably membrane-associated, associates with high density membrane compartment like early endosomes.
Sequence:
MSLNFLPGRPNATPQTACQATWQNHTIFAYCSGNNLIILTNKFTRLQTIYTQSDCTAVDINSQNGFIALSFHNRVLIYKPIHQIMQNPKWTQCCQLFHDDTPVNCLRWSSDNELAIGSDFLSFWKIKDNFGVYQPILQWNQKQPKPVYNVIISQDSQLIVSIGKYDCNAKLWKRVSIVGEQAIFNLTMLPHPKPITAMRWKKEPDQVSKNNTASHALYTLCEDKVLRIWSCFEMEKNHTVQIWGEVPLSPTQKFCVIIDNWIIRQTLSVKDSEIFDISDSDIVILGSMTGEMEVLALNNLSQDPPKPMTKKTISHKKVKKATMLNDTRYLYLPEIQPYDNVKGKLSFLVHDLQGVIRHLLIDILQLINNKTEDLSAALEHKFTGHNKSVQKLVRSSDGEALLTTSRFSENGVWYPQKLNHGVSLRLQNTIQTESPIKFAVVHELGKQVICLLENGALQAWECPTNRKEDSEQKQSYLRVETRLKEEKKIHPIVMLNTPEPKHSHERHFTALIFSDGSIKAFEVSLTRGIFEVKSDSLDIDGDDIYKISIIDPVHQTFVSNRPLISLITKKGLTRTYKAIVNYNDRHVQWIKACEINTGIMNCTCIRGSSTGKLCIVNSTGKVMSLWDLNRGVLEYEETFHNPIEDIDWTSTEYGQSIVSIGFTGYALLYTQLRYDYTNNTPSYLPIEKIDITAHTAHNIGDSVWMKNGTFVVASGNQFYIKDKSLDLTDPFTYQSIGSRKILSNDILHLSSVLNGPLPVYHPQFLIQAIYANKLQLVKELLLRLFLALRKLDFESQDVSNLDSNLGMDPLKYFIAKDRDYPVESFPDPYPCFNKTVSLALTEQLTKTTLPYLTRHQQITLITVIEAVDEVTKNENIVDYNGVRFLLGVKLFLSHKNIQKSILMRDVSWALHSDNKEILLSSIDRHITSWNRAREYRIAYWIKEQDLVKKFEDIAKYEFSKDDKRDPSRCAIFYLALKKKQILLSLWKMAIGHPEQQKMVRFISNDFTVPRWRTAALKNAFVLLSKHRYMDAAVFFLLTDSLKDCVNVLCKQVHDMDLAIGVCRVYEGDNGPVLGELLTAQMLPETIKENDRWKASFIYWKLRKQEVAIKALLTAPIDLENNSSIVDKEVCVNRSFLVEDPALLYLYNHLRNRNLKYFIGSLNVEAKIECTLILRVTDILCRMGCNYLAVSLVKNWKFIERNSIPVQKLLKSPTKDRAYSAIGAMASEPISTARMRPSLFDKFGSPSASDIESPNPKLPNSLLDDFLQPPPNSTSSNSLAQSSSSAPRSILDEFVSPSYSQHKENLTPKAPNDSVGETDNSENRKDKLSKDILDDLSSQKPQKPKKSAITKNLLDDFV
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MEAPVVKFKKRGAKAAPRKAAPPPPQSDSDFSSGSEAEGEDGRVVKRRKTNGNALKASTADQKMGSGIEGTTKYEADRSAVIEASNDATKQSNWYDENADGTLNSKSLLGTTRTKPQTIIEKSADAPPRQVGPQKSSSNVRTITITDYTPDVCKDYKQTGFCGFGDNCKYLHAREDYAAGWKLDREWEMSTKGKKLEGTVVASANRDEKDKDDDGIDLAMLEKIPFACLICKKPYKTPIITKCGHYFCEACALKRYRKDPTCAACNAKTQGVFNGAKNLQKLLDKKQRWEDKKKAEAEAAEKEAAGGE
The following text describes a protein:
Function:
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MVSSNQDLLISPSIPYGEIAVPPSKSHSLRAILFASLSKGTSIIENCLFSPDSQAMLTACEKMGAHVRRIGDSLHIQGNPDPHHCHPRYFHMGNSGIALRFLTALSTLSPTPTLITGSHTLKRRPIAPLLSSLKQLGAHIRQKTSSSIPFTIHGPLSPGHVTISGQDSQYASALAITAALAPYPLSFSIENLKERPWFDLTLDWLHSLNISFLRDQDSLTFPGGQSLESFSYSVPGDYSSAAFLASFGLLSSSSKPTILRNLSSQDSQGDKLLFSLLKQLGAHILIGKHHIEMHPSSFSGGEIDMDPFIDALPILAVLCCFAKNPSRLYNALGAKDKESNRIEAIAHELQKMGGSVHPTRDGLYIEPSRLHGAVVDSHNDHRIAMALAVAGVHASSGQTLLCNTQCINKSFPYFVIAAQTLHANVRHYQADFPLRSSFCR
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MEFRFENVKPARTPAVAYPKEITCYSVDGNRDILYNDSNLRFYYPPPLGTDLNIGFPKRYTKPLNQPDSISIVENALLNNCKDVISSAEIVSWRGLLTKLLCAPVDYKSSWDILVYKKESTLFFEEPPRAPEKPYANQERMCFWGYKFETVSTLPKIWDECSRSSIEQRDYDHVNPNEQYCSIVKTSIGSHSMILGGEVDCVWDIKPDYEEDNPCTHYVELKVTKKLPLNHVGMRRKLIKYWAQSFLLGIPRIVVGFRDDNGVIVEIKEMSTTEIPKLLKPAVSRNEWTPSRLLVHLEQLLTWLKSIVQNDSHTSWKLSYRGQGSITLQKTSSSP
The following text describes a protein:
Function:
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Subcellular Localization:
Chromosome.
Sequence:
MLKAGDSFLQMASGNLVEALIRRTLLEDSIPTSHDPSPRSHDPSPRVDEGPKVKSKKRPRDGTGDGAVGGQKGAKTGKGRADGGKTGAKKSSEANSSKKDKGPESKKTKQSEKVEIVDDRKEKNKSDCKQSEAEERAEVLDKDDARPMEGEAKAECLQNGEKTLLNAKKVLMENNNEDTLSKKPEGEPKELDDLGGKSGNIADVSSSEDTSKAAAGKDTIVPSKERTVKGHQNERTGKAPEAFPHQQPKELPLRSPDQGKSIRSHTIGGLTIASMIEKTLDAGIISSLRGERFKDIMLPKSKGKDRVSRDKDDGFPMKMVNQKKDGKSEPSVTSSMSSSTSLSVAPAVSNKYSVERILAAPTRSDNPKKDLLLKGIIPATRNVEGQRTFDPKLVTSSSRKLMAPFSIDIPIASSEMPSSSSVTSSGNSMGNTPPGSDNCMVSPDGSDESMSGNHSGVSDGGATSPSPGDGSTSSQNKKKKRKRCGVCKPCLTKQNCGECSSCKNRRTGHQICKMRKCVELRKKALAAAASGAGQQPTGLLDGGSAAGSPRMKGVRPPSLPTGGTDGQDMSYLPNVPVSDGAPPNQVVGKNGQVMQWNPAGPNAPPAQPQMMNGYSDQYPHHLPNHHLPQHPQQPQQQQSPQLPQSQPQLKGEDAPKTGQELTRKEALPKMSPGEPAPKTAKGVEQGKPGKEHGLSAFSPTPDSVSKPHAPAHTPPGMARELAERHYYEKMVQQQQQQQQKLADPHEIAAAAAAAAAAAHRSIPPQSYPHHPHHLSMPHKPEINNHIPIKKEILSPVVGVTGTPIPPPDKKSLSPVDAAESLLSLSTTLPDKTNQFTVGNSFSHAKPSVSTMMLAPLPQPVKKESTGSKSTPGPRPSEISSPSSGAPTKIPLNPLEPAHPDGVAARAEVQKMARQVPPSPYSNIMLPTIMQKSDGRMGLAKTALSMSSHGISSTHAIQGGTGDKVEGGGKGTTLHPTPPTVDSLMERQKLEKGLQTPPRSTDKPVIETPEMKHMQLISEDARIEAPNCGCLENDMDEAPYYTHLGTGPNLPAIRELVEIRSGFQGSQVRIEKVVYSGKEGKSSTGCPIAKWIIRRSSTDEKILVLVRHRPGHRCDTSYIIIAIVAWEGVNNYVADDTYEMLRTTLPNGAIPTVRRCGTNEDKTCACQGFSPDSCGASFTFGCSWSMYYNTCKFARSRTPRKFKLLEANPEVEDVLSDRFQNMATDLGPLYKRLAPESFNNMVVFEEEGKECRLGKETGRPFAGVTACMDFCAHAHKDQHNMNNGCTVVVTLTKDDIRNKRPSPGDEQLHVLPLYYLDSTDEFGTAEGQQNKVRNGSIEVLTHYRHKIRVHGGDPVVPKGAMKSRNSSSSNSSPGRAKSAASAAAAQRELEREREKEKEREKEKEREREREHEREREREHEREREREHEKRAAAAASAAQKELAAAGHGIPKVEQPVPPHMNPQTMQMWPHYQQSMEALRAQWPGMEIPPGMVGGLRPDSHALMMMNGLHREMLTPGGSIPPELAHMYAHYARFLPPGYVHPAMADIMLREQLQNNPAALARFMAPFGQDPYGGQSSNPYMHLAAQYGADIKPDPSMLNNPRLEGFYSPYLSPHLTSPQGREPGREGGSHLPSDASSKFPSPTLNGVRPDPHHPHTSQAHHPTSSSSATSSSTSSAQPHLSSSHSHKDGIWRPPIFQDSPKKEPNSGGHHHSSSSNSSSRPPESRTPQKSPAYSPSVDKSIRPGDPRDPYIFRDDTPSSKPVHHHKSEGKSSKGKSDPHHLHQAAHPERLTPHEGKDIKPIFPIPSLQDPMNTPPPARSEEEYFSDSDKCFEDPTIGGVAIALTHGSVLFECAKRELHATTSVQNPCRQRPTRISLVFYQHKRMTYRNHGLELYEKKMAARSLEQENGESPSGKGGKKGKRPATTDDSNKESVAAKKKKTEVEKSQIPTKCAVTPSTNTTVTLASYAFPTVTGPYQKWV
The following text describes a protein:
Function:
Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (By similarity). Catalyzes the palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane (By similarity). Might also mediate palmitoylation of CNN3 (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MLALRLLNVVAPAYFLCISLVTFVLQLFLFLPSMREDPTATPLFSPAVLHGALFLFLSANALGNYILVVQNSPDDLGACQGTSSQRPQRPPPSTHFCRVCARVTLRHDHHCFFTGNCIGSRNMRNFILFCLYTSLACLYSMVAGVAYISAVLSISFAHPLAFLTLLPTSISQFFSGAVLGSDMFVILMLYLWFAVGLACAGFCCHQLLLILRGQTRYQVRKGVAVRARPWRKNLQEVFGKRWLLGLLVPMFNVGTESSKQQDK
The following text describes a protein:
Function:
Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond.
Sequence:
MAHLRLHGTINATILGADNIHDRSRHTGIVPSFLGNIVQGVQETTSLGKGLSRMYAAIYLGSACIARTRTIAVPAAGSARWNEPLRAYCAHHAADVVISVMIEQLGLNDDTVLGRAYLPARELLNANGTTIDRWFDVLGTDRNKLPDGPKIHVQISFRDVADQGLAWGGGVGDGVVPHTFFSQRPGCRVTLYQDAHASAEFDPKIRLDGGGLYKPGRCWEDIYDAISNARHLVYITAWSMFPHITLVRERDGRQETLGELLKRKAGEGVHVLLLVWNDISSIDGLHEVGVMDTRDQLTAKYFRGSRVQCVLCPRNWSVRGYILDAKTPVDTVVYSHHQKAITVDQELPASSGSDGRRQIVSFLGGLDVCNGRYDTQSHSLFRTLGTGQAHSNDFSQINFSDEAATLDKGGPRTPWHDIHAKVEGAAAWDVLHNFEQRWSKQGGGKEHLVDLVALEGKVAPSSWPVTLPGDQEAWNVQLFRSIDSISTVGFPDSMEDAYEAGLIQDKHRIPRELSLKIVSKIEAGERFAVYVVVPMWSEGTPTGRYRQAMLDNQRRTMALMYDDIAVALQAKKIDADPRDYLTFFCLGNREAKSEGEHLPAKHPKDGTDYARAQKARRFMIYVHSKMMIVDDEYIVVGSANLNERSMAGDRDSEIAIGAFQPHRVNTDAELAKGHVHGFRMSLWHEHLGKTHDDFLRPGSLECVRRVNKMADEYWNLYVGDQQLTDDLPGHLLTYPVAVSKAGTVSTLKGFEFFPDTKAPVLGKPTGINDYFMSI
The following text describes a protein:
Function:
Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MIPEIGSFLLCLALAISLLLSLYPQWGAARQDARMMAVGRPLTYGMFAAITLSFICLIYAFVVNDFTVSYVAANSNSYLPIYYRIAASWGAHEGSLLLWVLLLSCWSLAVALFSRSMPEDAVARVLSVLGMITGGFLLFIILTSNPFSRTLPDFPIDGRDLNPLLQDVGLIFHPPLLYMGYVGFSVAFAFAIASLMAGRLDSAWARWSRPWTQAAWIFLTLGIVLGSAWAYYELGWGGWWFWDPVENASFMPWLAGTALIHSLAVTEKRGTFKAWTVLLAITAFSLCLMGTFLVRSGVLVSVHSFASDPARGMFILAYLVIVIGGSLLLYAVKGAQVRSRTQHEVFSRETFLLGNNVLLIAAMLVVLLGTLLPLVHKQLGLGSISIGEPFFNTMFTWLMAPMALLMGIGPLVRWRRDEPSKLWKRLSVALVVTLLLSISVPWLLQDSVAGMTVVGLMMAIWVIILTLMELHERATHRYGFWRGLTHLSRSHWGMVLGHLGVAVTVIGIAFSQNYSVERDVRMKAGDSIDIHDYHFTFRDVHDIKGPNYTGGVGIIDVTRNGKLEATLHAEKRYYSVARSMMTEAAIDGGLTRDLYAALGEELGDGSWAVRLYYKPFVRWIWFGGIFMAVGGIFCMLDPRYRMSKKLKRGAIPEAES
The following text describes a protein:
Function:
May be involved in iron transport and iron homeostasis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MREPLLDHETSSPQPSSPLHLTKYLYSGHFLARWGARMWDFSVALYLINIWPDSLLLAAVYGVWVDRLSYVKVLQLWLVTQNFSFIFAGGTVLGLLAYPDLKSTSVQAFVLLILLTNVSGAVGVLSTLAGTILIEREWVVVMSEGQAPILLTRMNSVIRLIDLICKFTISVWPEYWLFMSVYQGIPALAERNRQRTQKPFPAELTESLSVPDDDHPANAEKSRKRSLGEKIANLPLVSAWRVYFEQEVVLPGIVLALLYFTWTLLLLCVGSIWVQNSIIAAYMLMGGVAASRLGLWMFDLAVIQQMQDKVSESDRCVAGGAQSSLQSTLHVMAYGMGIIISNPQDFWKLILLSFLFTTLSASLYTFHVYHVRKHPIHFEKLILLRSWSIVRSPDTHQSQNV
The following text describes a protein:
Function:
Catalyzes the first two consecutive steps of tetrahydrofolate biosynthesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MAPLLSQTLIHTGRFLLRRFLEPPPAVISAVAASRVCFHRYYSSKSLSLVSPLGLHCSSLFSPPALCNSAFSSSATSTTIEVQSTEHEVVIALGSNIGNRMNNFREALRLMKRGGICVTRHSCLYETAPVHVTDQPRFLNAAVRGVTKLGPHELLSVLKTIERDMGRKDGIRYGPRPLDLDILFYGKMRISSDKLIIPHERLWERSFVLAPLVDLLGSAVDNDTVAHWHSLAIHPGGIFQAWERLGGESLIGQDGIQRVLPIGDKLWDFSNKTHVMGILNLTPDSFSDGGKFQSIDSAVSRVRSMISEGADIIDIGAQSTRPMASRISSQEELDRLLPVLEAVRGMPEMEEKLISVDTFNSEVASEAISNGADILNDVSAGTLDPNMHKVVAESGVPYMAMHMRGDPCTMQNKENLQYDDVCKDVASELYLRVRDAELSGIPAWRVMIDPGIGFSKSVDHNLDIIMDLPKIREEMAKRSIAVSHAPILVGPSRKRFLGDICGRPEATDRDAATVASVTAGILGGANIIRVHNVRHNADAAKVCDAMLRRRRSKG
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MGLKNLFFFKTSPSPLPPSFPPTRTFSDSLMDENIETARAIISKWELISPSDQTAPLFSNTRQEAKQYLNAVMSLQSTMQHLVALDSSSDTLVQAHFLMQLAMKRLQTEFYRILAQNRDNLHPESVTSTDHRSSSVSDDGTNFSDDEFRFAGDSISTVAMVDLKAIAECMVSAGYSKECIKTYILTRKSMVDEALYHFGVERLSFSQVQKMDWKVLESKIKSWLSAVKFAIRTLFHGERTLCDYVFGSPERKIAESCFAAVCREGAESLFAFPEKVAKCKKTPEKMFRTLDLYEAISDNRLQIESIFSSESTSSINFEAAIQKESSKIPVPGGGIHPLTRYVMNYIEFLADYRDCVAEIVADWPQNSLPESYYCSPDREGMNRSAEIAERMAWLILVLLCKLDGKAELYKEVALSYLFLANNMQYVVVKVRNSKNLGFIVGEDWLTKHELKVKEYVCKYERVGWSKVFLSLPENPTAEQARAIYECLDAEFHETCKAQSSWIVPDPKLREEMKDSIASKLVPRYREFFGKYRVGLGTDFGLTPDDLEHNLSDILSGSVSSSHTPSPPHRFKRP
The following text describes a protein:
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.
Sequence:
MGPRSRQRRTGTVQSTNDSSSLSKRSLAAQGYVSDAFAPLLVPGIVRRTPLIHRGYYVRARAVRHCVRAFLDLTGAIRSPTRAQILSLGSGSDSLYFRLKAAGLLTRTAVWEVDFPDVSRLKAKRIEETPELCAQTGPFKIGDSASTLCFESSDYRILGADLRELQRLGEALDSAGLDATSPTLILAEAVLTYLEPSRAAALIAWVAQRFPNALFVIYEQMKPGDAFGQIMLQHFRRLNSPLHGLELFPDVEAQRQRFLQAGWTTCSALDLNEFYRRLIPADERRRVETLEPFDEFEEWHLKCSHYFILAASRGDILSETPVFLPSEASFQIDPALPSGFLSASVVTSDHQHSSLQRYGHTSVLLSPGIIFSAGGFGEQEGRHCRVSRFHLLSRSCDSEWKGCQISTLGTEGQWDGRLYHTMTRLSDTRVLVLGGRLSPVNPASGALQLDIYKSEDNCPEGQNVVVTKAALEEGSMLSCWRHSTTEVYYQNQRYLFVYGGRSVTDPVLSDCRFLHVETMAWVRIPVQGSSPEGRHSHSACSWQGGALIAGGLGASEEPLSSVFFLRPVSSGFLWESIHIQPSITPRYSHTAHVFNGKLLLVGGVWIHSSSVPGVTVISLTTGLSSEYQIDTASVPWPLMLHNHSSALLPEEQQLLLIGGGGNCFSFGTYFNPHTVGLDLSSLGLGQ