lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling. Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein. Essential adapter molecule in IL17A-mediated signaling. Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways.
Sequence:
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVTCLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSLGGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPWNYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNRAGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGIDIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMMQIEFIKQGSMNFRFIPVLFPNAKKEHVPTWLQNTHVYSWPKNKKNILLRLLREEEYVAPPRGPLPTLQVVPL
The following text describes a protein:
Function:
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVERKTYFLTHIILWILIPLILFPVVWVVSTSIRRDEAAFSTKIFSSRISLQNYKDLLAPEKNMPALVQELQNLIMLTPPYDTWDRGRVEREIEKDISNLKSYIDETKSRYDKAEKGYRDLNNYLALKTNEIKNNIYLQLEALKKYLEENLPKKGEESNLSIKLSELKILKERINNLNYKISQNREEYNKVLVKIDALQREILEINNKINALNNEITFLNNKLDQYSLVSYKKASSLDRVFSSLIDRLSKYLDFDLLLQNIRSLSRKIKYFTSDSKYLYFQASFLKVSENLNNLIDQLDAKVSELNAYNRKVAILNQENEFLEMQKELLQNQEENIKEEVRPLTKVDQLKEFISSLDAKLDKLQTVDGLDALINEVSVWEGEFRDFVTSYIIEYGRDNLSSRIENTADKFKWFNDYKTLKDRFENLSSYLTKNLQKANELTSIIESRWRSFFEKSLQGDKTYLPELDSLYNLIKTDFVNFVSANMNIVSKKAGDLMDNVPFKETKRWLNVIDSELFRIDQIWKQKTKHYFLKWVRNSIVVSGIAAIITTLICSLAAYPFSRMRFWGRRYGILTLLLIQMFPSAVYMIAIYSLLNILGRFIPFLGLDTLSGLTFVYLGNIAYNMYLIKGYYDTIPDSLEESAMIDGATRFQTFYKIVLPLARPILTVVVILTFMSIFNEFIFARIILQDAQKYTYAIGLWTFSSGPYQTEWGLFTAAALLGMLPMTILFLSLQKYIVSGLTKGAVKG
The following text describes a protein:
Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
Subcellular Localization:
Nucleus.
Sequence:
MGDDEARSWIRGDETAKQMLSRVLKDRAFLLIPPLHRVPLRAGNVVEITGASTSAKTQILIQAAISCILPKTWNGIHYGGLGKLVLFLDLDCRFDVLRLSQMLKHRLLQANWLGNGAWWQLEESNVKSCKSAEEKTKTVFDEELYASCMKRFLYVRCYDSLELLSSLKTLHYRIQQQEACGSQVGVLMIDSIGAFHWTDRLSSSLALETHNRKSLSLTNVVETIVQELKKLLLVHSLVVLATKGTIYEEKYPANENNRKVSSNDHFSGNVASKAQQPPFREFMPSSWQAFVTHKIIIRKSADYQSLQTGQQNLLAYSLEWLQPQLSRIDRFIVDDVRKLTTIKPFYSKLLLIYIVIPASSSHAVWYCHCLVT
The following text describes a protein:
Function:
Pore-forming protein, which is involved in efflux of copper across the outer membrane. Essential for copper resistance and maintenance of a low intracellular copper concentration. Required for virulence.
Subcellular Localization:
Cell outer membrane.
Sequence:
MISLRQHAVSLAAVFLALAMGVVLGSGFFSDTLLSSLRSEKRDLYTQIDRLTDQRDALREKLSAADNFDIQVGSRIVHDALVGKSVVIFRTPDAHDDDIAAVSKIVGQAGGAVTATVSLTQEFVEANSAEKLRSVVNSSILPAGSQLSTKLVDQGSQAGDLLGIALLSNADPAAPTVEQAQRDTVLAALRETGFITYQPRDRIGTANATVVVTGGALSTDAGNQGVSVARFAAALAPRGSGTLLAGRDGSANRPAAVAVTRADADMAAEISTVDDIDAEPGRITVILALHDLINGGHVGHYGTGHGAMSVTVSQ
The following text describes a protein:
Function:
Serine/threonine protein kinase involved in the regulation of exocytosis. Induces phosphorylation of SEC9 and its release from the plasma membrane to the cytosol.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MPNPNTADYLVNPNFRTSKGGSLSPTPEAFNDTRVAAPATLRMMGKQSGPRNDQQQAPLMPPADIKQGKEQAAQRQNDASRPNGAVELRQFHRRSLGDWEFLETVGAGSMGKVKLVKHRQTKEICVIKIVNRASKAYLHKQHSLPSPKNESEILERQKRLEKEIARDKRTVREASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSNIFDYRKQLHTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLVCGKVPFDDENSSILHEKIKKGKVDYPSHLSIEVISLLTRMIVVDPLRRATLKNVVEHPWMNRGYDFKAPSYVPNRVPLTPEMIDSQVLKEMYRLEFIDDIEDTRRSLIRLVTEKEYIQLSQEYWDKLSNAKGLSSSLNNNYLNSTAQQTLIQNHITSNPSQSGYNEPDSNFEDPTLAYHPLLSIYHLVSEMVARKLAKLQRRQALALQAQAQQRQQQQQVALGTKVALNNNSPDIMTKMRSPQKEVVPNPGIFQVPAIGTSGTSNNTNTSNKPPLHVMVPPKLTIPEQAHTSPTSRKSSDIHTELNGVLKSTPVPVSGEYQQRSASPVVGEHQEKNTIGGIFRRISQSGQSQHPTRQQEPLPEREPPTYMSKSNEISIKVPKSHSRTISDYIPSARRYPSYVPNSVDVKQKPAKNTTIAPPIRSVSQKQNSDLPALPQNAELIVQKQRQKLLQENLDKLQINDNDNNNVNAVVDGINNDNSDHYLSVPKGRKLHPSARAKSVGHARRESLKFTRPPIPAALPPSDMTNDNGFLGEANKERYNPVSSNFSTVPEDSTTYSNDTNNRLTSVYSQELTEKQILEEASKAPPGSMPSIDYPKSMFLKGFFSVQTTSSKPLPIVRHNIISVLTRMNIDFKEVKGGFICVQQRPSIETAAVPVITTTGVGLDSGKAMDLQNSLDSQLSSSYHSTASSASRNSSIKRQGSYKRGQNNIPLTPLATNTHQRNSSIPMSPNYGNQSNGTSGELSSMSLDYVQQQDDILTTSRAQNINNVNGQTEQTNTSGIKERPPIKFEIHIVKVRIVGLAGVHFKKVSGNTWLYKELASYILKELNL
The following text describes a protein:
Function:
Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox-dependent manner.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSIPDYAEQLRTADLRVTRPRVAVLEAVNAHPHADTETIFGAVRFALPDVSRQAVYDVLHALTAAGLVRKIQPSGSVARYESRVGDNHHHIVCRSCGVIADVDCAVGEAPCLTASDHNGFLLDEAEVIYWGLCPDCSISDTSRSHP
The following text describes a protein:
Function:
Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane. Note=May localize to mitochondria-associated endoplasmic reticulum membrane (MAM).
Sequence:
MEASVLSPTSWEKRRAWLRQSRNWQTQVLEEEAAAALQDVPDPEPSSLDDVFQEGNPINKIEDWLQDCGYSEEGFSEEAGQFIYNGFCSHGTSFEDDLTLGAEATLLAANGKLFSRSFLETARPCQLLDLGCSLASSSMTGGTNKTSSSISEILDKVQEDAEDVLFSLGFGQEDHKDTSRIPARFFTTPSQAKGIDFQLFLKSQVRRIEMEDPCLMLASRFKQVQTLAVTADAFFCLYSYVSKTPVQKFTPSHMFWNCNHPTDVPSIRILSREPEPQSPRDRLRKAISKMCLYTCPRDRPPPPHNTPKRNSLDQVVLEVMDKVKEEKQFLQQDSDLGQFSQEDPVPPAEGKKLPTSPYPCVFCCEEETQQRMSTVLAPSQTLDSNPKVPCCTHSLPIEDPQWSTDPAQIRRELCSLPATNTETHPAKDETFWKRKSRARKSLFQKNLMGRKVKSLDLSITQQKWKQSVDRPELRRSLSQQPQDTFDLEEVQSNSEEEQSQSRWPSRPRHPHHHQTFAGKDS
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MEDSVAIGDCGSVIPELETEKSLTAAAKHIARASGSKKNVTDDAKKILADLDTQLFNTSTVNEIKVDTPGEIEGQLNFIQEKIMSWETDQSMMRDSGLDEATQFLNATEEARKLAERLETLSLNKDDGKKELLTRARDILQIAMGRLEEEFKHHLDQNRRAFEPERMSFCLSEECGTEPGSVISLGDGSVEPLISRDSISRTSEEFIIDLVNPEVISHLRKIANLMFISGYGDECSQAYISVRRDALDECFFILKKKEVSFEDVVKLEWGSLNSQITKWVQAMKIFVSVYLPSEKRLTQLIFGEHDFFVRTNGGEILWRLRDSVMEAYLDFENAIETGVPPHPCAGGGIHDLTRYVMNYINTLNDYHETLNFLLKGLDGEDPISLSPVPSGITYDASPMALHCRSVASILECNLDDTAKLYRDPSLQHIFLMNNIHYMAQELDNLKLMHLFADDWIRKLNWKVQQRLMSYERTTWVSVLSLLMVVGPSYSVSKNLIKEKLRRFHLAFEEVYRTQTAWLIPDAALREDLHISITTKVIQAYRTFVGRYSNFITPKNVKYSFDDLENFLLDLFQGSKKSLPYRRFFFVI
The following text describes a protein:
Function:
Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The EGF-like region is specific to this family of proteins and seems to consist of the C-terminal of an EGF-like domain fused to the N-terminal of another one.
Sequence:
MKTKTSIFQFIVASVLTLLINDSSAATPPPPISNSSTSCNKTCGGISIPFPFGIGGKDCYLNGWYEVICNTTTSDSNTTVPLLSMINREVVNISLPDSNEPYGLVQIKGPVTSLGCSSNTSEGPQNSLPVLNVTGKGSPYFLTDENRLVAVGCGIKALMTDTESEILGCESSCEHRKSGEEVTNLICTGYRCCQARLPVGRPQAITVNIENSSGGEETCKVAFLTDKRYSPSNVTEPEQFHNNGYVVLELGWYFATSNSRFKSLLGCTNMSRKGSGFSDDNCSCEYDYFSGMSYRNCYCDYGYTGNPYLRGGCVDTDSCEGNHNCGEDAHCVNMPGPMSMCRPNPKITKPTKPPVLQGILIGLSGLVFFVGLFWLFKLIKKRRNINRSKKFFKRNGGLLLKQQLTTKDGNVEMSKIFSSKELRKATDNFSIDRVLGQGGQGTVYKGMLVDGSIVAVKRSKVVDEDKMEEFINEIVLLSQINHRNIVKLLGCCLETEVPILVYEYIPNGDLFKRLHDESDDYTMTWEVRLRIAIEIAGALTYMHSAASFPIFHRDIKTTNILLDEKYRAKVSDFGTSRSVTLDQTHLTTLVAGTFGYMDPEYFLSSQYTHKSDVYSFGVVLVELITGEKPLSRVRSEEGRGLATHFLEAMKENRVIDIIDIRIKDESKLEQVMAVAKLARKCLNRKGKNRPNMKEVSNELERIRSSPEDLDVRTENEDEEEDQPMAINNKR
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLLLFSLYFNLLLSYAAGLVPFRYNFRKRRFDTCKPFVPVATVLLLLFAAVQYRLGRLPERMKIPKVGMQDIIHAVENLVLNGNCVLIAVQQLLFLETYRQLLTDLLAGVRALARRTTVALGEQVQLLVQLVLLPCATYTLHVSVYITLIEWAEISIVQAVLFMVSLIPNIAHVNNFYALLFVQRLTLGEINDMLADLWTICIRPGANELLPPSRRLQLHLQQYQQCAGSVQKILPYYSLSVALYLLILFQELMSKVHISGESWLQFLITYRLTFNFFYQFTHFYTLSLGNPSPHILEAMGTMMILVYGMYTAQLIAECYAISEKSQKIKSTVHRLSLIPGQDRYFHATINTFLLSLNHSMLKINIAGMFTMDFELLTGMLAAISNFVVLLMQFHIDYSKSKISYWHGNNSSKPLTVRS
The following text describes a protein:
Function:
Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone. Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9)and ubiquinone-10 (Q10) respectively. The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.
Subcellular Localization:
Mitochondrion.
Sequence:
MGVLPKINFAVRQLRKCSMTATSSVSSSDPSLASSAFVQDHVRQMQNDIMEQLIPQDASGAVENLADLNVTSNLGRMTHYYFQQGGKMLRPTVSLLMGNACNSAMNRSIPEEQIAIPISERSAISSHLIVCQNQYKIGMIAEMIHTASLVHDDVIDEANTRRGSASVNAVWGNKMSVLVGDFILARATQILCSIGKPNVIAVMASIIEDLVLGEFMQMSVTPSEATPSQRMVAYIEKTHRKTASLFASSCRSTAILADSSNSNLHQTAYEYGRNLGIAFQLADDLLDFIATSDEMGKPVAADLKLGLATAPVLYACEQYPELTTMLLRKFKHEGDAERARDIVMNSDGMDKTRQLIDAYSQKAVEMASSLPNRNESTEQLIKLALSQTDRKF
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MAPADASCSEVASCHRFQSPKQPHPNDVKKREKKLLVTTRNPLSLSLSLSLSLSLSFLSLSLSLSLSLFSLSLSLSFLSLAANWHLTGGKFNDEKPGLKLKHDARGILSMANSGKNSNTSQFFITLGPQPKLDGKHVPFGRVVAGLDVLDKIEATAAPTDGPPLHPIRISACGAC
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Nucleus.
Sequence:
MACSSNWVAHVDVYVDPDCSTSKQVDSRNAISKLLLDKTITIQQLVLVAGKYLTSNDNAIRARGLLLLAELLEDLANTPMEDTAIHSLASFFSNRLQDWHSLRPALIGSIALARRPKRVGAVQPEDAETLGRSIIEQLDVQALSQKDRMLSLELYESLLTLHVSSMEPLGPELVLGIIAAIEEEKDPRCILVAFRLVEKLASIFPEPDGPFGENAEDIFDIVSRYFPISFNTPQDPRGITREDLSSALLKVFTATPLFAPFCFPVLLEKLSSTLKRAKLDALNYIGHCALSYDPEALSEHAGDIWTGLKSEIFRQEDGVSDQKDSLILEEAFSCFARCIEASQKVRTNEDDITGDFMKLVLEDDCVVGFLRRVKNELDQEIDPGDGIKTYALTTDAQLQAVGRLLGAAARASCTSCYIVTKTFLSSLLPSVEVVSPKSSDHQSSESVAAKGHSISLEAGLSLTGLEAVIFVLEGARHLANVLADSSNPSSSEFALKYWLDPVILAAPVLIDTFSRVVASGVVTTVLKLGVAGLQALASYPATLSPLSEDQLETVLTFLTSTFLDQTKGSELKDQALGAILAASNLEEKCTDLHRQEFLSSREKEKVSVLNVVLPKLLDAVQEACSPEPLDFHLRALAALSASRESVREKVLKVLGQLVPSKLGQTLALADGSFEFAKAVMIFRCLSGQIIPFCEIGSVGQLAACDVVMDIWRSIGSLPQSTVYIAPDILLPLMEVIRVTVQRCPERLQKEILTMSLSVLQGGYSPEQNTKLSGVRSLSAKHMEGKEWLVALVGSVIVGLLPSVLFEERESVLRLLVSTSVANLDPVITDTAAQAAASMLNKWNEKKSESEEAGSFPLKEAITIAVDEGWMPIIKQVRRDGTGDMPNSFCAEDAEKSAARSIYALALAGKGLAMRGHSRIADIAGAMLRVLESLGKPVAYSGTTDSFEMKDQSDKLTESAVGRAAVESFGLIVNEHASFLSKSQNAVIRPLYKQRFFTSILSPLIEAVRLDSNQSSRIWFYRSFACLLSGTPLGAVLTEGKRVFPLILEGLSTLCTYPEDSEYVLQLLLSLSSFLVDESNGRSFAAEYVQSMVNRLVPVSQYKSSMMIRESALQCLAAIVGLSFTRVFPVKSQVMKAITIALDDKKRLVRKEAVRCREVWSAITST
The following text describes a protein:
Function:
A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
AWKAKKESFVSGLNGTSFLEVTICSAAYPLCVLVRALVLGVLPKPMLNSNSFRYVLDFLLVVFPIIIMLTGLSEFIFEAALIVLVSITLYFKTFFKKKNISETTRIQAAYVSKLYYKHQVQDIELPFLTSFRVSVNAVTCICILAVDFNIFPRRFAKAENFGMGVLDLGVGSFVVSNALVSQAARNWNKIGGRSGLNKSFSFLFFQLFSSWPLFLFGFLRLASVKLSGYHEHVSEYGVHWNFFFTLAVVKVLATVILFIFPLEFCSPLAVAIAASYQYLLSGNNEKMTQLIFGSNREGGLLMQNKEGIASCLGYLSLYFAGVQLGAFIFKERRTLAKWKEAAKELLGCTLMLWSLLHFSNYAIQPISRRLANVSYCIWILSQSTLMLFLFLMVDILTTQNINAGYLPNESMPDPWLMEKPKEDTKIDYNPPPPKKCLISAINRNQLLFFLLSNLMTGAVNGLFDTQAVSNTNSIVIITIYAVCVTFITWLLHIKQITIKMW
The following text describes a protein:
Function:
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
Subcellular Localization:
Cytoplasm.
Domain:
Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
Sequence:
MAVERKKWSENFSEWYNELIETAGIQDKRYPVKGMNVWLPYGLKIMRNIERFIHAEMERTGHDEVLFPALIPETEFQKEAEHIKGFEGEVYWVTHAGLEPLDVRLILRPTSETAMYSMFSLWIRSHADLPFKIYQIVNVYRYETKHTRPLIRVREISRFFEAHTAHDSYEDAERQIKEDLEIFDNLARFLALPYIISKRPEWDKFPGAYYSLGAEVMMPDGRTLQIGTMHNYRQNFAKAYNIQYETETGDHEYVHQTTFGMSERLLAAVIAIHGDDRGMVLPPTIAPIQVVIVPIPKKDSEADVFAYAREIAEELRTAGIRVHVDERDIRPGRKYYDWELKGVPLRIEVGPRDVEGKKAVLARRDTLEKITVERDNIVEEVRKTLDAIHENLYQRAKEFLESHIKRVDTIEEAKAVFEDRRGIVEIPWCGEEECGLRMEEELDAKMLGIPYPEEKAKAPEGKKCPVCGREAKFIARFARTY
The following text describes a protein:
Function:
Involved in the pollen tube perception of the female signal by binding an unidentified female attractant. May be involved in the regulation of root hairs development.
Subcellular Localization:
Endomembrane system; Single-pass type I membrane protein.
Sequence:
MMGCGFHFPWFFFLIIGLQAPLSLSLTSQGSALLKFRARVNSDPHGTLANWNVSGINDLCYWSGVTCVDGKVQILDLSGYSLEGTLAPELSQLSDLRSLILSRNHFSGGIPKEYGSFENLEVLDLRENDLSGQIPPELSNGLSLKHLLLSGNKFSDDMRIKIVRLQSSYEVRLKKSPKLSPLAVLGCINRKLGHCVSRNRIIQVKKVEAIVFRIKATSRRFLKAFPSFLEETDIYKRRELLEETSNLAAEPAPSAPSPSPGIITEASPRSSGSFPAVTNAKKRRPPLVPPVPSPDKGSTSPDISKNQPQDNKQSKGSKHVWLYVVIAVASFVGLLIIVAVIFFCRKRAVKSIGPWKTGLSGQLQKAFVTGVPKLNRSELETACEDFSNIIETFDGYTVYKGTLSSGVEIAVASTAIAESKEWTRAMEMAYRRKIDTLSRINHKNFVNLIGYCEEDDPFNRMMVFEYAPNGTLFEHLHDKETEHLDWSARMRIIMGTAYCLQHMHGMNPPMAHTDFNSSEIYLTDDYAAKVSEIPFNLEARLNPKKHVSGDLEQTSLLLPPEPEANVHSFGVLMLEIISGKLSFSDEYGSIEQWASKYLEKDDLGEMIDPSLKTFKEEELEVICDVIRECLKTEQRQRPSMKDVAEQLKQVINITPEKATPRSSPLWWAELEILSSEAT
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MKSESPEGVDTCTAQRDVEGSSSSHHVHANAYRPGSRSSMYPELFQQMVCTVLESESYLFSNSELDILSAFFMLSYPARYLFVRLLQRKKNTWYRLDRLEAYRSEVHDLKAATAELATIISSPPSDGPKIETGRVEEQDRRKLALDTDKENSVLALPALQRQLELDEQTGLPRAPTYRHKQPLVESSVPANNAAQTETPKPKTSTELQGPLLNRFVLTERDMIGGLSESLSLLTIEELKAIAKNMGITKIGTTRAQIVATLTATRSQSMLFKIPIKRSDASQNAASTGASKQLTLNLVSPNKGQPQASRLKHELSATLGGGCIQVLPALRSLVDRVALVYYRGNLLGSAALTTAILSRSHIRNYPSYDYRRTSFLFPSRDHLIAFERALGIEAEMEHLIQFAKSEADFRCALALFDSVWAEWNSCVQECMSAHPEGIDKLVYHRMRFHPGWVLTRIVYKGAGVLARLKLREREKQVLQALLDQKVFRRGRRGDWYDRLALVTALYSDDQRKGKRQALEISVRGMQDPDTHLIYHDTLQRRIARLESQLRIPRSEQHDFSYTKLKTTSEVEFKGVRLDAMTETDTRTNQPITALSRFLHTCSSPPPSPDEPEPRSASDTPPRSGLASRSARSSSSKVSPTKRSCGFEIRKPLFKRVKIETFAETSTFKRETESSLFSPSVKMECEEAIDDQSRPILGAQDSSIDSIIVKEEDLDEISWDEMCAAPDATALYMMSGGEAACCMTTSTRRSMRSVWRGLDKRPCHVEQLCLQHYALQGFKGYHCEGKLLTMIFVLVMWDVIFMQGIPGSFETPYQSAPLDLGSDSFGIVRSQQIRERLDHIERTGGLDLIDAVDDRERANKTWAVGCRWDLFSKQDLLEVAECLGGHSISVVCQMLVEEWDHCSSGMPDLVVWRIKDKVVRFVEVKGPGDRLSETQKVWIDVLLRAGIQVHVGLVREE
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
KPLVNARALNLLKTRAGREAGLFPTTQRPPLNRRHFGPGRNRADAGRKEGAGLWTEPLAQLNGVEAKSAGKTLIQITMVNILQLVRDHWGLTLVPIGFVVGCYFDRRNDEKLSLFRNKSKLYHRELKPGEEVTWR
The following text describes a protein:
Function:
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity). Interacts with p24delta5 at endoplasmic reticulum export sites for endoplasmic reticulum exit and coupled transport to the Golgi apparatus.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Note=Cycles between the endoplasmic reticulum and Golgi via COPI and COPII dependent pathways.
Domain:
The cytoplasmic C-terminal domain contains an Arg-Val motif, which is involved in the anterograde ER-to-Golgi transport of the protein.
Sequence:
MSLKGTIVLLGLLWSFQATLGIRFVIDREECFSHKAEYEGDTLHVSFVVIKSDSQWHFNEDGVDLVIHGPTGEQIHDFREQISAKHDFVVQKKGVYRFCFTNKSPYHETIDFDVQLGHFAYYDQHAKDEHFTPLMEQISKLEEALYNIQFEQHWLEAQTDRQAIVNENMSKRAVHKALFESFALIGASFLQVYLLRRLFERKLGMSRV
The following text describes a protein:
Function:
May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.
Sequence:
MGTPASVVSEPPLWQVSTAQPRDRGRGRKQASANIFQDAELVQIQGLFQRSGDQLAEERAQIIWECAGDHRVAEALRRLRRKRPPRQNHCSRLRVPELGSTAADPQASTTDTASSEQFGNSRRTSARVHRNWNKPGPTGYLHQIRH
The following text describes a protein:
Function:
Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. When present individually, LchA1 exhibits activity towards L.lactis HP. When combined with LchA2, it displays activity towards a broad spectrum of non-pathogenic and pathogenic Gram-positive bacteria including strains of L.monocytogenes, methicillin-resistant S.aureus, S.pneumoniae and strains of vancomycin-resistant enterococci, but not towards E.faecium L4001 and BM4147-1. Combined LchA1 and LchA2 peptides also inhibit Bacillus sp. HIL-Y85/54728, L.lactis DPC3417 and B.halodurans C-125, which produce lantibiotics themselves. Inactivated by proteinase K and pronase E, but not by trypsin and chymotrypsin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MSKKEMILSWKNPMYRTESSYHPAGNILKELQEEEQHSIAGGTITLSTCAILSKPLGNNGYLCTVTKECMPSCN
The following text describes a protein:
Function:
Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of threonine and methionine from aspartate.
Sequence:
MDIIIVGFGAIGKGIAKVLYDKKDYLKKNYEEFKVVAITDSSGAAIDEDGLDLLKAIEVKEKTGKIKNYPEKGREMSSIDVIKEVDADVVVEVTPSNLETGDPAKTHILESFKNKKHVVTANKGPLALCYKELIEEAKKHGVIFRHEASVGGAMPIINLAKETLAGNEILSIRGILNGTTNYILTKMEKEGLDFETALKEAKELGIAETDPTQDIEGLDTAAKIVILANSIMGMNKTIKDVKVKGISRITPEALFLANKRGYTIKLIGQIKDGYLIVEPMLVPIDSPLNVKGTLNVAMFETDLAKEVVVVGRGAGPIETASAILSDLIHIYNSTKK
The following text describes a protein:
Function:
S-adenosyl-L-methionine dependent O-methyltransferase that may be involved in modifying resorcinol ring to synthesize a variant of 4-methyl-5-pentylbenzene-1,3-diol.
Sequence:
MSDWDKTMDLLFGFVTGHIHSRMFETILKFSICDLLEDGPKHYSEISKIIGFKNESYCYRLMRYFVPYKLFNESVVQVGLFSKTPSSTQFSKNGTLKNLGRFHCQDHHYRIFESLPKTLEMGKNQGPSSIGLSSFWEHFETDESYKQLFHNAMKDYTSLIIDRLISKISLSPNFKTVVDIGGSHGFLIGKLLESNPNIHGINFDLENIINSSTSKNENFQHPRLKHVSGDFFNSVPEADCYILKYILHDWSDEKCITILNNIHKSLKPNGKLFINDLVLDPSNYTKEAVFKDILMMQYFDAKERSINEWHQLFEKCGFKIDSVDTSISPQLMIVSKINSSNINLNDCTNFNSEIVEEKLKNSLPQFVNC
The following text describes a protein:
Function:
Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2.
Subcellular Localization:
Nucleus.
Sequence:
MRTSPRRPLILKRRKLTLLQKEVSSTSGRDENSGHDEKTPKQEHSQNDQNDSQCRDKIDCGLQIFSAGIKIMNHPTMPNTQVVAIPTNADIQSIIEALTAKGKECGNNGPNKFILISSGGTSHSAGLVLSQHLPSMEEPSTVARTANSQVREKNVSQTPDLAGGSMVWHSGIDSAFAQKRENSSGEAMSSVLDNSLTNIQWLGKMRTDGLTPCSVKQGMEKENQIPLRERMKTEEDSAAVSIPSSSSWQDSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHVAKPGWKNSIRHNLSLHDMFVRETSANGKISFWTIHPDANRCLTLDQVFKMISVFGGKKKRVLWLLLLELLWDAFILQPLDFGSTSSEHSESQQKQHVPDPQKNMGSKSSSKTEPQNARRKMKPLLPRINSYLVPIQFPMSQPLVLQPPLKVPLSVAQGTSHNSSETFQSNKRVRIAPKMSFSIEESSSLPMATVKEESQCDEGFFSPTHSLKENNCQPGDEPCSFPETLCIKEEEGLQLGDWLSPFASTVTVKEEPDSFVPVSAVMEKKCFTILKSPSKGVSDALVIKRCERREMSRSRRKQHLALPCSEEPVLIFPESNEFDPFQLGADLPLLQENQPLENASQLRCLQEERGPFKTPVKEMFSKLPVSSTPCKVPATTTPPLGGLDPWKSALSAKRGNELDFSPVRTLPLPFTPCQENQDLLGFNSTPLKSPLPESSWELLNTESNDTVHSPLTSSPSFSHKSTKQLSLELPASGFTENRSLVEGLILDTMNDSLSKILLDISFPGLEDENLGTDISWSQLIPELK
The following text describes a protein:
Function:
Participates in the sulfur mobilization (SUF) pathway for iron-sulfur (Fe-S) cluster biogenesis. Involved in the pre-assembly of [4Fe-4S] clusters and their transfer to target proteins.
Subcellular Localization:
Plastid, apicoplast.
Sequence:
MTIHIFLCFLLILKIVNALKSNRFSSYIYTPKTFLYNNKSIPNKKLVRKFVNRIKLVDDTIKSNEHIIKITDNATNKIKELQKECNDDYLILKLYVENGGCKGLKYKLNPIKKNEIEEDDYIQQFDELKFILSIDSTSVIYIYNNTLDYSNDLISGGFKFINPNATKKCGCGKSFNV
The following text describes a protein:
Function:
Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex.
Subcellular Localization:
Nucleus.
Sequence:
MEWDSDSEGPSDGEEEGFLLSGGAGAFSFAVEGMLRPASSCGLVVSDALEPDYPIIYVNRGFEEASGYRAEEVLGRNCRFLQCRGPFAQRRHPLVDATVVSEIRKCLEEGIEFQGDLLNFRKDGSPLMNRLQLTPIYGDDDIITHFIAIQFFTDTNVELGPLLSSTVKESARPDRLIASYVVQPISAGHGLICRELCSMLQLSDEVLCQKIFSRLSPRDIASVGSVCMRLYELTKNEDLWKMVCQNAWGSETTRALETVPGAKRLGWGRLARELTTLEAAAWRKLRVGGAVEPSRCNFSACAVGNRVFLFGGEGVNMQPMNDTFVLDLNASNPEWRHVKVTSAPPGRWGHTLSCLNGSWLVVFGGCGTQGLLNDVFILDLDAQFPAWREISGLAPPMPRSWHSSCTLDDTKLVVSGGCADSGVLLSDTHLLDVTMEKPVWREIPASWTPPSRLGHSLSVYDGRKILMFGGLAKSGPLRLRSSDVFTMDLSEEEPCWRCITGSGMPGAGNPAGIGPPPRLDHVAVSLPGGRILIFGGSVAGLHSASQLYLLDPTEEKPTWRILNVPGSPPRFAWGHSTCVVGGTRAIVLGGQTGEEWMLSELYELSLASSII