lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions; Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasm, cytoskeleton.
Sequence:
MSNTLTTERNITNSPTAAQLNEKESGKKEEEWIVGVLTTSDRVSQGIAIDQSGPEIVAIIKNQLKQMMGESCSINVITVYKVVPDEIEHIQQMITQWTHLKYKLILTTGGTGFTPRDVTPEAIKPLLNRRTKGIEIAMLKTSLDITPHAMLSRPIAGIRDQTLIITLPGSVKAIRENLGVVLPAIPHAIGLINSKPKSSLPESHRSKDYIKNSQIDSNLIINQNNQNNNNNNNNNNNNNNNNNSHNHHHHHHHSCGGSGKRGSSYNMTPVDEAIKIILEQCDNINNELEKVEITKSLGRILGEDISSVEPFPNFRASIKDGYAIRSKDGIGKYRLLGDSVAGNTGENLIPPQPQQPTNSINDDDNEKYCVRITTGAKIPDGYDSVVMIEETEMIGENMVSIEVTCKPGQDIREIGSDIASGTIVLNKGDKIGCAEIGLLATLGIQWVHCPKLPSISIISTGDELTDYQSKSDSMKSGIIRDSNSPTLATILQEISNHFGECCSRDNINLVGIIPDKLENLKDTLLDCSKKSDIIITSGGVSMGHLDLVKPLLEKIGTVHFGRVNMKPGKPLTFSTITTTTTDNNNQEEEKKKKTTLVFSLPGNPVSTVVTFYLFVVPALRKLGGFGIKNNGSQLNLPCVEVKLLDRIQLDHERPEYHRCTIEWDFQEHCFVSKSTGSQASCRLLSLKQANALLVLPQKHGHLEKGSMVKAILIGPINN
The following text describes a protein:
Function:
Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.
Subcellular Localization:
Nucleus.
Domain:
The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.
Sequence:
MAEAPPVSGTFKFNTDAAEFIPQERKTSGLNCGTQRRLDSSRIGRRNYSSSPPCHLPRHIPYEDISAVHQHSYASGSKPKSPQGFFQSSNKSLKNHGLQNQPWQKARNEKHQNRNKKAQGLSEQTSDTSSLESVARSESGTNPREHSPSESEKEVVIADPRGAKPKKAAQLTYNYGRGPKAKGRLRSEWGNRMSPKSEDENTRPVAISHTDSSDASCRKPVVDPCVCRRNEQRRYPQKRPPWEVEGARPRPGRNPPKQESQRHINAGPKTNMSPIPKDNLRERPTKSACDTGNLAVVSKSSRRVNQEKTAVRRQDPQVLSPFPRGKQNHMLKNVETHTGSLIEQLTTEKYECMVCCELVQVTAPVWSCQSCFHVFHLNCIKKWARSPASHADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRKKQPGQDCPHSCNLLCHPGPCPPCPAFTTKTCECGRTRHTVRCGQPVSVHCSNACENILNCGQHHCAELCHGGQCQPCRIILNQVCYCGSTSRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGSHTCSQVCHPQPCQPCPRLPHLVRYCPCGQTPLSQLLEHGSNARKTCMDPVPSCGKVCGKPLACGSSDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSLKSEDATFMCDKRCNKKRLCGRHKCNEICCVDKEHKCPLICGRKLRCGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPCGTRPPECTQTCARIHECDHPVYHSCHSEEKCPPCTFLTQKWCMGKHELRSNIPCHLVDISCGLPCSAMLPCGMHKCQRLCHKGECLVDEACKQPCTTPRGDCGHPCMAPCHPSLPCPVTACKAKVELQCECGRRKEMVICSEASGTYQRIVAISMASKITDMQLGDSVEISKLITKKEVQQARLQCDEECAALERRKRLAEAFDITDDSDPFNVRSSASKFSDSLKDDARKDLKFVSDVEKEMETLVEAVNKGKNNKKSHCFPPMNRDHRRIIHDLAQVYGLESISYDSEPKRNVVVTAVRGKSVCPPTTLTSVIERETQTRPPPPIPHHRHQADKAPGSSTLQKIVKEAVIDYFDVQD
The following text describes a protein:
Function:
Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP.
Miscellaneous:
MISCELLANEOUS: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.
Subcellular Localization:
Cytoplasm.
Sequence:
MYGLVIEGVRFMIQENWGPQVLLQVQKLTSLSEKSVSTHDQYSEHVVPQMFKAIHEITGTPYEQIGVLAGRFFVQFLIRNGYGDLMNVMGRRFSDFIKGLDNIHEYFRFSYPKLRAPSFYCKSESEDGLILHYRSRRTGYLSYVIGQLVELARVFYQLDIGIQVLKKKEKGRFTFVVLKISFDNVGLGQDLKLKERVKNLNEYLPVDTKSFLQMFPFHIAFNKKLEILMAGQGLLNLMPNIQGLLMTDVFDLQRPCIKFTAEGIMVHQNCVFQIESLHPVVKQTEENITVQINDITEDKVSLEKKTVMDNEYESLPYVTLRGPITVLKSSETFLLLATCVVDTLDTMFKMGLYLNDFGESDCNREIIMATIQKSDTLKTMLENEKRRSEVLTEMTREISEAKKTARTLLTQMMPYEVAQTMMRSGSVDHCEAFECVSIGFIRVCDFSKISLFIEAFEVVNLLNTIYSHLDSIVDTHGVYKVETIGESYMISAGCPYRDDYDAEMVSDCCLEMVSHIKSFEYQSHDAVKKVLIKCGIFTGPVVGGVVGVRTPRYCLFGDTVNTASRMESSNQTPMTIQIGQRTKDRVEKQASGAFRIKPKGNVFVKGKGDMRVYEIEKKKGRARYKKSDPLRKKMVAEKKEAEELLDEDNEGHRSSALSRMSLGESIDSSSSRRGSLSGSQLELNKTIAQTIELTSKASAALDLNMQDENNRPPTWSASHSQDIRKPRKTESKITLNSRLSSSDLAVSRVETSKDSDGETPRPTSSELKEVNRIREEALAQEKEEERTTKEENQKIEEVGEDHVSEATSLLDSEVSHGDNNISFSQMPSDSIPHEDRTSLPSATPSEIGDAISKKKLEKEDSNSSMSSLDERTTVSAKPTTTRRLLNQKDLEKEKKRSSMAGSSVTSSSAHSHSIRSKKDTRDKSRCKCEDIRADNKLKTKVCSIM
The following text describes a protein:
Function:
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence. Acts as a negative regulator in the phytochrome-mediated light responses. Controls phyB-mediated end-of-day response and the phyA-mediated anthocyanin accumulation. Not involved in direct flowering time regulation.
Subcellular Localization:
Nucleus.
Sequence:
MATQDSQGIKLFGKTITFNANITQTIKKEEQQQQQQPELQATTAVRSPSSDLTAEKRPDKIIPCPRCKSMETKFCYFNNYNVNQPRHFCKGCQRYWTAGGALRNVPVGAGRRKSKPPGRVGGFAELLGAATGAVDQVELDALLVEEWRAATASHGGFRHDFPVKRLRCYTDGQSC
The following text describes a protein:
Function:
Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping (By similarity).
Subcellular Localization:
Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies (By similarity).
Domain:
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MTAPEKPVKQEEMAALDVDGGGGGGGHGEYLQQQQQQQQQHGNGAAAAAAQDTQPSPLALLAATCSKIGPPSPGDDDEEAAVAAAAGVPAAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPGAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSNVQYQVIPQIQSTDAQQVQIGFTGSSDNGGINQENSQIQIIPGSNQTLLASGTPPANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDVNETNADTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTTSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQDSQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQITWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGALTSTPVSLSTGQLPNLQTVTVNSIDSTGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKVIHSSSTVLASVEAGRDDALITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME
The following text describes a protein:
Function:
Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MQLELSTCVFLCLLPLGFSAIRRYYLGAVELSWDYRQSELLRELHVDTRFPATAPGALPLGPSVLYKKTVFVEFTDQLFSVARPRPPWMGLLGPTIQAEVYDTVVVTLKNMASHPVSLHAVGVSFWKSSEGAEYEDHTSQREKEDDKVLPGKSQTYVWQVLKENGPTASDPPCLTYSYLSHVDLVKDLNSGLIGALLVCREGSLTRERTQNLHEFVLLFAVFDEGKSWHSARNDSWTRAMDPAPARAQPAMHTVNGYVNRSLPGLIGCHKKSVYWHVIGMGTSPEVHSIFLEGHTFLVRHHRQASLEISPLTFLTAQTFLMDLGQFLLFCHISSHHHGGMEAHVRVESCAEEPQLRRKADEEEDYDDNLYDSDMDVVRLDGDDVSPFIQIRSVAKKHPKTWVHYISAEEEDWDYAPAVPSPSDRSYKSLYLNSGPQRIGRKYKKARFVAYTDVTFKTRKAIPYESGILGPLLYGEVGDTLLIIFKNKASRPYNIYPHGITDVSALHPGRLLKGWKHLKDMPILPGETFKYKWTVTVEDGPTKSDPRCLTRYYSSSINLEKDLASGLIGPLLICYKESVDQRGNQMMSDKRNVILFSVFDENQSWYLAENIQRFLPNPDGLQPQDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILSVGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWVLGCHNSDLRNRGMTALLKVYSCDRDIGDYYDNYEDIPGFLLSGKNVIEPRSFAQNSRPPSASQKQFQTITSPEDDVELDPQSGERTQALEELSVPSGDGSMLLGQNPAPHGSSSSDLQEARNEADDYLPGARERNTAPSAAARLRPELHHSAERVLTPEPEKELKKLDSKMSSSSDLLKTSPTIPSDTLSAETERTHSLGPPHPQVNFRSQLGAIVLGKNSSHFIGAGVPLGSSEEDHESSLGENVSPVESDGIFEEERAHGPASLTKDDVLFKVNISLVKTNKARVYLKTNRKIHIDDAALLTENRASATFMDKNTTASGLNHVSNWIKGPLGKNPLSSERRPSPELLTSSGSGKSVKGQSFWAGENTVAVEEEELSKGKEMMLPNSELTFLTNSADVQGNDTHSQGKKSREEMERREKLVQEKVDLPQVYTATGTKNFLRNIFSPKSTEPSVEGFDGGSHAPVPQDSRSLNDSAERAGTHIAHFSAIREEAPLEAPGNRTGPGPRSAVPARVKRDLKQIRLPLEEIKPERGVVLNATSTRWSESSPILQGAKRNNLSLPFLTLEMAGGQGKISALGKSAAGPLASGKLEKAVLSSAGLSEASGKAEFLPKVRVHREDLLPQKTSNVSRAHGDLGQEIFLQKTRGPVNLNKVNRPGRTPSKLLGPPMPKEWESLEKSPKSTALRTKDIISLPLDRHESNHSIAAKNEGQAETQREAAWTKQGGPGRLCAPKPPVLRRHQRDISLPTFQPEEDKMDYDDIFSTETKGEDFDIYGEDENQDPRSFQKRTRHYFIAAVEQLWDYGMSESPRALRNRAQNGEVPRFKKVVFREFADGSFTQPSYRGELNKHLGLLGPYIRAEVEDNIMVTFKNQASRPYSFYSSLISYPDDQEQGAEPRHNFVQPNETRTYFWKVQHHMAPTEDEFDCKAWAYFSDVDLEKDVHSGLIGPLLICRANTLNAAHGRQVTVQEFALFFTIFDETKSWYFTENVERNCRAPCHLQMEDPTLKENYRFHAINGYVMDTLPGLVMAQNQRIRWYLLSMGSNENIHSIHFSGHVFSVRKKEEYKMAVYNLYPGVFETVEMLPSKVGIWRIECLIGEHLQAGMSTTFLVYSKECQAPLGMASGRIRDFQITASGQYGQWAPKLARLHYSGSINAWSTKDPHSWIKVDLLAPMIIHGIMTQGARQKFSSLYISQFIIMYSLDGRNWQSYRGNSTGTLMVFFGNVDASGIKHNIFNPPIVARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMQNKAISDSQITASSHLSNIFATWSPSQARLHLQGRTNAWRPRVSSAEEWLQVDLQKTVKVTGITTQGVKSLLSSMYVKEFLVSSSQDGRRWTLFLQDGHTKVFQGNQDSSTPVVNALDPPLFTRYLRIHPTSWAQHIALRLELLGCEAQQHV
The following text describes a protein:
Function:
May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles.
Sequence:
MHKKIYLSPPHMSGREQHYISEAFRSNWIAPLGPLVNSFEEQLAERVGVKAAAAVGSGTAAIHLALRLLEVKEGDSVFCQSFTFVATANPILYEKAVPVFIDSEPDTWNMSPTALERALEEAKRNGTLPKAVIAVNLYGQSAKMDEIVSLCDAYGVPVIEDAAESLGTVYKGKQSGTFGRFGIFSFNGNKIITTSGGGMLVSNDEAAIEKARFLASQAREPAVHYQHSEIGHNYRLSNILAGVGIAQLEVLDERVEKRRTIFTRYKNALGHLDGVRFMPEYAAGVSNRWLTTLTLDNGLSPYDIVQRLAEENIEARPLWKPLHTQPLFDPALFYSHEDTGSVCEDLFKRGICLPSGSNMTEDEQGRVIEVLLHLFHTVEVKKWTASIR
The following text describes a protein:
Function:
Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.
Subcellular Localization:
Cytoplasm. Nucleus. Note=at late pachytene a fraction is nuclear.
Sequence:
MEVSGGDTCRPRHPQGLREGPEPKVAAAAAAFRGSANRCWNLSVDTSNRLSDVFNSMMLTGSAPFYDCYKSQNEDNVDLRQTCTPLSSSTEYASSIDSSLFYAPWSTYGDDIKQPPSSQISVKNRIQTERNDYGSETDLYGLVSNILEEQDKSQPYFAEGTCSSNLKSVWPMNTSRFVDHHDLLTEPKRPVDTSISQQAFYSGESVSAVEKQYLHNSSLTPQQKIDELYHGYTGLDLEEQWLYLSRSDHSNCYNSQANDTVKATFQEYPFVKNCFTPQTGLSDIMKESGIDTYAYGREKICTKGLETPLQHKRAEIFLSQFNRYNENADYCRYPEYAHPNKAKLNKCSNFSVQDGKKLANGTPETPTVEADAYTKLFQVKPANQKKMEETIPDQQNFAFPKTTPHLTEKQFAKEAAFTADFGLKSEYGLKPHTACPTNNDFANVSEKQQFAKPDPLNSEYFKSVNLFSNSATSSGGISLNRPTWMNVQTKNNLPIPYRNQGNLMKLNSHLSAASKGSNHSSDFPQLSSTNLTSNSNLFQKYCQENPSAFSSFDFSYNGAERIQSVNHMEGLTKTGEDNLFESVTEKKIKQPNGFCDSYSASQYGIIENVNKHNFQAKPQSGHYDPEDIPKHFDGLPQNTYQDLLESQGHFNSHRQGSGDNNINSRVNRTQASCFSNNYMMGDLRHNQGFQQLGSNGFPLRSTHPFGHSVVPLLDSYDLFSYDDLSHLYPYFNDMMYGDNSFSGFVPTFGFQRPIKTRSGPASELHIRLEECYEQWRALEKERKKTELALAKNYPGKKVSSTNNTPIPRLTSNPSRVDRLIVDELREQARVVTLLGKMERLRSSPLHANISTALDRHLESIHIVQSRRKDEIVNASNRQRQGVPRCQDDRDVFALATAIKEMCVATRKARTTLWCALQMTLPKTASTAGQADMEKAFQDLVNCEEKVHESINSSNPMNQRGETSKH
The following text describes a protein:
Function:
Cell surface glycoprotein promoting cell-cell contact to facilitate mating. S.cerevisiae A and alpha cells express the complementary cell surface glycoproteins A-agglutinin and alpha-, respectively, which interact with one another to promote cellular aggregation during mating.
Subcellular Localization:
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP).
Sequence:
MFTFLKIILWLFSLALASAININDITFSNLEITPLTANKQPDQGWTATFDFSIADASSIREGDEFTLSMPHVYRIKLLNSSQTATISLADGTEAFKCYVSQQAAYLYENTTFTCTAQNDLSSYNTIDGSITFSLNFSDGGSSYEYELENAKFFKSGPMLVKLGNQMSDVVNFDPAAFTENVFHSGRSTGYGSFESYHLGMYCPNGYFLGGTEKIDYDSSNNNVDLDCSSVQVYSSNDFNDWWFPQSYNDTNADVTCFGSNLWITLDEKLYDGEMLWVNALQSLPANVNTIDHALEFQYTCLDTIANTTYATQFSTTREFIVYQGRNLGTASAKSSFISTTTTDLTSINTSAYSTGSISTVETGNRTTSEVISHVVTTSTKLSPTATTSLTIAQTSIYSTDSNITVGTDIHTTSEVISDVETISRETASTVVAAPTSTTGWTGAMNTYISQFTSSSFATINSTPIISSSAVFETSDASIVNVHTENITNTAAVPSEEPTFVNATRNSLNSFCSSKQPSSPSSYTSSPLVSSLSVSKTLLSTSFTPSVPTSNTYIKTKNTGYFEHTALTTSSVGLNSFSETAVSSQGTKIDTFLVSSLIAYPSSASGSQLSGIQQNFTSTSLMISTYEGKASIFFSAELGSIIFLLLSYLLF
The following text describes a protein:
Function:
ORF4 polyprotein codes for VP4a, VP4b, and VP4c, three of the four proteins that self-assemble to form the icosahedral capsid. The capsid is made of VP3 (coded by ORF3), VP4a, VP4b and VP4c.
Subcellular Localization:
Virion.
Sequence:
MQNPTQTMHIYDMPLRVIAGLSTLAKTTEEDDNTSTGIVVSEVGEPQVVNHPAWIDPFVAYQLRAPRKNITPDFIFGRADIGNAFSAFLPRRFSAPAVGTRLVVDPVFTYQQRTVLGLYNYFHADFYYIVHVPAPLGTGIYLKIYAPEFDTTTVTRGIRFKPSASPTIALSVPWSNDLSTVETSVGRVGQSGGSIVIETIEDNSNETVNTPLSITVWCCMANIKATGYRHADTSAYNEKGMNFISVPVPKPPVPPTKPITGEEQADNEVTAEGGKLVQELVYDHSAIPVAPVVETQAEQPEVPVSLVATRKNDTGHLATKWYDFAKISLSNPANMNWTTLTIDPYNNVTLSRDGESMVLPWRRNVWTTGSKSIGYIRTMVAQINIPRPPQISGVLEVKDSINNSSISLVEFGGKVEIPIIPKVMNGLATTASLPRHRLNPWMRTAESKVELQYRIIAFNRTSDIADLNVSVLLRPGDSQFQLPMKPDNNVDTRHFELVEALMYHYDSLRIRGEEQSLPENAPNAVSNPQQFITPATALSAEEYNVHEALGETEELELDEFPVLVFKGNVPVDSVTSIPLDLATIYDFAWDGEQNAISQKFQRFAHLIPKSAGGFGPVIGNYTITANLPTGVAGRILHNCLPGDCVDLAVSRIFGLKSLLGVAGTAVSAIGGPLLNGLVNTAAPILSGAAHAIGGNVVGGLADAVIDIGSNLLTPKEKEQPSANSSAISGDIPISRFVEMLKYVKENYQDNPVFPTLLVEPQNFISNAMTALKTIPIEVFANMRNVKVERNLFDRTVVPTVKEATLADIVIPNHMYGYILRDFLQNKRAFQSGTKQNVYFQQFLTVLSQRNIRTHITLNDITSCSIDSESIANKIERVKHYLSTNSSGETTEEFSRTDTGLLPTTTRKIVLGESKRRTERYVAETVFPSVRQ
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MMPSLRILHCEKIALTRARDESVVAPSSRTLQQKRSPSAQRSITMDDNYRELAAEGEEYDHASSFEPVSSFGFAYNDPRWSDRELRLIVRSDFSGASLDTSISRIDIKCAVHVDPDEEEDFVDDDGNIYDQFDVETVKIPVNSVILAKESPFFRSLFGGNGFRDCNSHTVDIHINPEERCTFHAMIECMYTNSVSLTEVEEFISLWGLAERFLVHNCSQLCLRRLRDMPLDLDQAIRIHEAAYNSNPSGELRSVIEASTHFLIRHFKKLSFVNSKPTSKHSRESNKELLRDFVSLAQSALRALLASDDLEVEREEIAFYALILWVKENTFSVAESQLMMTQLAPLIRFPFMKPDVLSGLLEYPELASPTCQELVIQALKFRTASEDMKHKLRGDGAGHHRRFEKRSGYLRPVNCLVLEQPKKQAVVHFDTSPAELEALQPSGHLTFEGFRVAGSVFAFQIHHVFTASTRKKVGLDLRLCGSSPAGRIQAELNISVWSVPLMMFVHRFHAKHTFQVDNPLLRCADLFGKDLAELLAEKSQWVCDGRIFLHAELSIRS
The following text describes a protein:
Function:
Acts at least in part as component of the WASH complex which may regulate wash nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting (By similarity). During embryogenesis, not involved in the wash-dependent developmental migration of hemocytes anteriorly from the tail.
Subcellular Localization:
Early endosome.
Sequence:
MDATAAITGNVDKTQIPPLNQKRILAFVNHFLVSTCTFLNEFALGCETKFVEMERQLQKTEAALIILEAKLASIPTEHHVATEATEAPAISNQQRNEEASMVDTTEPPTTENPTEPELPPESVGVRACEDQRYRKFFKMVQVGVPAPAVKQKMQSEGLEPRILDTPDLILADGQRE
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSRGFNVAHQKVSLDVDLGEKVLRGSTEITIVPSDLSIRQFRFDCRQAQIKSVLVNGKKATFTHHDASGYEAFSDSRTVSDVHQHHLYRKYIDHAHKEVLEGELEVNLPRGVKVSYQDTSRETGPAADEEAVGVYAPLIVTISFVVRDPKTGVTFVGGHGSRLKKSFWHAYTTHAPIGAATSHWLPCVDGLWSRCTWQFEVTVPRTVGSLGGARVEEEEPDVDMEDADDDEGLEGATPRVKEELADENVVKKELTTETGSPKQTVDDDDEDEEMEQDDKEEELDLEMEIEIEVVGNGAAVEELSHADASKKTIAYSLWNPVSAQHIGFAVGPFVEAPLPDFRDTDEDEDGGTPAGFPIKVFALPDQVSDASNTCVFLHKAIEFLTNEYGSFPFDAMSVVFVSEYGKAQMGASGGLCVASDDFLYPPDVVDPLLSSTEALTVALTTQWCGVNIVPRTWNDTWLTQGLAIYMAALFMKRLMGNNEYRYRFKRLAEMICEEDVGRPPLAKPHFRFPLFPKDLSFINLKAPGVLFILDRRMTKIDKTFGLSRVIPRIFLQSLSGDLVNNALGTNHFYKLCERVSHCKLDEFFDQWVYSSGVPVLQVTQRFNKKRMFIEMGIRQTQTDKSGEKKPVEDTFIGDVIRSEEGVDHGDEEEGGPKTPLFTGPITIRIHEADGTPYEHVVDIKHIFTKLDIQYNTKYKRLKRNKKEVEAAATVTATAAPPAASASNNEEDEVGVVISCLGDVLQTDAELEEWELSEWGKDEEMRMSNEAFEWLRIDADFEWICKIHVNQPDYMYASQLQQDRDVVAQYESVQFFAESRPSKVYSTILLRTLIDRRYYYGVRVAAALGLVKMAVSETSYIGQTHLLKAFQNLFCFPNSSIPRSNDFSDFPTYFVQKAITRAFSQIRNGDGECPAEIRTLILDILAYNENSTNSMSDSFYLSDLITFLADVLCSSDSNDESTREFAARAVNEIDRCGRLDTWIPSYQNVVTVAALEAKKRLFLKGLFSAKLQDLIQFTRSVNSSEVRLAAFEAMLHIGGLRNHYIMHYVFASAALDDSARVRNGIIDLFTRYLGTLAIKGDMSADNHADDNDGMIVDDGTQAAMEARKVQMARTSLTGAADILRDMLRQDTSLQTELWDSLRSPYHGLEAKSQLLDVCQVLFVPVDAFKVKLSTPSLIKLGVDYSSGSSLALRVESNIPAPEKTAVLPAIKSKRLKEQAQRSEIVVVSKNNPKVKYSVRPGFRITTNPGPKKKEVKRLSVKLSFK
The following text describes a protein:
Function:
Involved in allosteric regulation of aspartate carbamoyltransferase.
Sequence:
MTHDNKLQVEAIKRGTVIDHIPAQIGFKLLSLFKLTETDQRITIGLNLPSGEMGRKDLIKIENTFLSEDQVDQLALYAPQATVNRIDNYEVVGKSRPSLPERIDNVLVCPNSNCISHAEPVSSSFAVRKRANDIALKCKYCEKEFSHNVVLAN
The following text describes a protein:
Function:
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
Sequence:
MNGDTRAAVVTSPPPTTAPHKERYFDRVDENNPEYLRERNMAPDLRQDFNMMEQKKRVSMILQSPAFCEELESMIQEQFKKGKNPTGLLALQQIADFMTTNVPNVYPAAPQGGMAALNMSLGMVTPVNDLRGSDSIAYDKGEKLLRCKLAAFYRLADLFGWSQLIYNHITTRVSSEQEHFLIVPFGLLYSEVTASSLVKINLQGDVVDRGSTNLGVNQAGFVLHSAIYAARPDVKCVVHIHIPAGAAVSAMKCGLLPISPEALSLGEVAYHDYHGILVDEEEKVLIQKNLGPKSKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLASAGGPDNLVLLDPGKYKAKSRSPGSPAGEGTGSPPKWQIGEQEFEALMRMLDNLYRTGYPYRYPALREKSKKHSDVEAPASVTGYSFAGDGDPGTCSPLRHSFQKQQREKTRWLSSGRGDDASEEGQNGSSPKSKTKVWTNVTHDRVKPLLQSLSSGVCVPSCITNCLWTKEDGHRTSTSAVPNLFVPLNTNPREVQEMRNKIREQNLQDIKTAGPQSQVLCGVVMDRSLVQDAPLSDCTETIEGLELTEQTFSPAKPLSFRKGELVTASKAIIEKEYQPHVIVSTTGPNPFNALTDRELEEYRREVERKQKGPEENLDETREQKEKSPPEHAAAPHTPPSTPVKLGEDLPQEPISGEDSDAATFKPTLPDLSPDEPSEALGFPTLEEEEEEGEALSEAREPPSPTGSPVAASPEPASAQVAEEAASPAAEEGAAVDPGSDGSPGKSPSKKKKKFRTPSFLKKSKKRSDS
The following text describes a protein:
Function:
Required for the assembly of cytochrome c oxidase.
Subcellular Localization:
Mitochondrion intermembrane space.
Sequence:
MKTSPSKTEDEQKEDQRLLGEINARAFPSGPSTQQDLIDRRRQKKDNQTETLASHQAPEADPNQEEKSRKIPSKLVDPCQAARKASHRCLDRNNYDKSLCYDYFEVYRECQKRWVDSRKK
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAPSSNYQLYGLKIGFPPGGLMRNKQMKFNDYGITVKEAIQIITNKQGMQNPDSYTLQITYSDEPSSINTSSGNIGSNNNSSSNTPLTGSLGMGPPPPSASIGGGGGGGDNGITNSGNIGSSSNSDLKKSTSSGIVNVNNSSNAPTRRLKWMDDNEKLISYPLGAHDVVIELKKKYQLIKVYDGKQTMNLIVDITKPLSDLMDLVSCKFKLRSTSDCKLFTYGKEINLNSNIKNLNIDTSLPFILRDNNDPNSLSLESIQWDNGNGFFVGGNGGIGGIGSDDDADDINNNLSVPAKSIINPVREGYLKKQDKKKSWKTRYFKLTDKYLYWYKSPTAIKASGMIICKDYHIKLAPSTHSKEVKLEFTPKHMIAGATTIIHYIKFENEQELKQWTVLPIVIESSNDSGSNNSNTSGGNQSMIGKKVFGVPIEKTVSGNNEIPAVVLQTIDYIEKKAMDIVGIFRLSGSVLTIEQWKAKYDKGEKVDLFQEVDPHAVAGLLKLYLRELPDPLLTYEKYDNFIAAQSIDDFPSRIKLIKHLVKSLPPVNYAVLSYLMAFVGKVATHSAANKMQVHNLSTVFGPNLIKDRQDSGDYGNNVQVLVEDTPIINALALSLIRDYQYIFTDKEIPEQKILAKSLYEYAGNDDGTTSEDDKDLLFPKGATIKVTQQGTDGWWTGEYQGKQGKFPASYVELLPHSPSTLLRTKSNSNLTKKKKFMLEMESTKTKNQEIDKNIKQLEITKKELESTINDLENEKAALENDPTIKAMMNLLANAKTNKDIAMIPKNIDVLFQKFEEYKSSHEALATTKTTLIDEYEQFNNNPKKRLDTKEKEQIQQKYDNLSIIIDKSQKIRSKSINSKKIINDDLVELKKIFSL
The following text describes a protein:
Function:
Functions as part of ribonuclease MRP (RNase MRP), which is involved in rRNA processing in mitochondria.
Subcellular Localization:
Membrane; Single-pass membrane protein. Nucleus, nucleolus.
Sequence:
MQELQYDVVLLQKIVYRNRNQHRLSVWWRHVRMLLRRLKQSLDGNEKAKIAILEQLPKSYFYFTNLIAHGQYPALGLVLLGILARVWFVMGGIEYEAKIQSEIVFSQKEQKKLELQSQDDIDTGTVVARDELLATEPISLSINPASTSYEKLTVSSPNSFLKNQDESLFLSSSPITVSQGTKRKSKNSNSTVKKKKKRARKGRDEIDDIFG
The following text describes a protein:
Function:
Probable GTP-binding protein that may be involved in cell development.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNGALQQIQLIDGEGNYNLTGIESFARRVKLAECGLSYAVIAIMGPQSSGKSTLLNHLFGTKFVEMDALRGRSQTTKGVWLARAPNVEPTTLVMDLEGTDGRERGEDDTTFEKQSSLFALAVADVLLINMWCHDIGREHAANKPLLKIVFQMMMRLFTPRKTKLLFIIRDKTKTPLETLEPILREDIHKIWDSLPKPNKEKEVLFEDFFQIEVVALSNFEEKEEQFRDQVAELRGRFQNSIAPGGIAGDRRGVVPGTALALSMQEMWKVIKDNKDLDLPAHKIMVATVRCEEIAAEKIAELKSNQHWLELERKTQLGPVAGFGKQAGDLLKAVLTGYDTEAAFFDESVRAEKRKGLFTSAVGVIHESFTTLLGHRRAEALDKFKAELAASGVPSTSSDGPPSKDADVPGFAEARRRCTENALKAFDKAAADALVSGAGWDYLRTRQKLQRDIDAHATAVRTERLAAIQTKAKDTLQGKLAEPASSLLDAASSETWPGLRELLARETAHAKQELAAAVAGFEVEAEESGALEGALEDAGREAVEKRAKEESTQALIRMKERFNTLFGRDSESMPRTWAGKEDIRAITREARIGALRLLSVLAAVRLDDIDGPDTVAEALETLLEGQEGSMALHPHSEGGSAAGAKEAPSRNALAGATWENIPSSATLLTPSACRSLWRQLKAETEYTISSAIAAQEAHKRNNSWLPPPWAIVAMIVLGFNEFMALVRNPLLLCVVVAAYYVGRALWVQLDASAEFENGLVPGLLSISAKFVPTLLRLLKRLYEDGQHTVQHATGIQMHDFAASNSSTTWEQNGYGDDVSSRATGVASRPVRHRGSAAQSSGMADVRKVQTDSS
The following text describes a protein:
Function:
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event. Also mediates peroxisomal fission. May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
Sequence:
MVKYFGTGDVISCHVIQSGRPFSLFSGNMEAVLSDIVAPEDLLKFEKKYNSELDKGAVSKDTKFEYAWCLIRSKYSGDIQKGIALLEELVQKSPKDDSRDFLFYLAVANYRLKEYERALRYIRTLLKNEPENKQALEMEKLIDKALKKDGLVGMAIVGGIGLGVAGLAGLIGLAVSKGVAKS
The following text describes a protein:
Function:
Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity (Probable).
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MKQEQQPTPGARATQSQPADQELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEELLGKGFGLHNPEPRWINDTVVVYKTNNGHVMKLNTESNASTLLLDNSTFVTFKASRHSLSPDLKYVLLAYDVKQIFHYSFTASYLIYNIHTGEVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEGIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPNMIIPRFTGALYPKAKQYPYPKAGQANPSVKLYVVNLYGPTHTLELMPPDIFKSREYYITMVKWVSNTRTVVRWLNRPQNISILTLCESTTGACSRKYEMTSDTWLSKQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLVQSKSEQITVRHLTSGNWEVIRILAYDETTQKIYFLSTESSPQGRQLYSASTEGLLNRDCISCNFMKEDCTYFDASFSPMNQHFLLFCEGPKVPVVSLHITDNPSRYFLLENNSVMKETIQKKKLAKRETRILHIDDYELPLQLSFPKDFMEKNQYALLLIMDEEPGGQMVTDKFHVDWDSVLIDTDNVIVARFDGRGSGFQGLKVLQEIHRRIGSVEAKDQVAAVKYLLKQPYIDSKRLSIFGKGYGGYIASMILKSDEKFFKCGAVVAPISDMKLYASAFSERYLGMPSKEESTYQASSVLHNIHGLKEENLLIIHGTADTKVHFQHSAELIKHLIKAGVNYTLQVYPDEGYHISDKSKHHFYSTILRFFSDCLKEEVSVLPQEPEEDE