lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8A, together with C8B and C8G, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity.
Subcellular Localization:
Secreted. Target cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells.
Sequence:
MFVVAFFGLSLVAWHPGVTAQEKVNQRVTRAVTPQAVSCQLSDWYKWTDCFPCQDKKYRYRSLLQPSKFGGTICSGDIWDEASCDSPTPCLRQAQCGQDFQCRETGRCLKRHLVCNGDNDCLDGSDESDCEDVRVTEDDCHQYEPIPGSERAALGYNILTQEEAQSVYDAKYYGGQCETVYNGDWRKLRYDPTCERLYYGEDEKYFRKPYNFLKYHFEALADTSISSEFYDDANDLFFHIKNGKSHSAGVTVGVAPVKSPVSIEVTGSGSKASSFLNKLNKYNEKRYGFMRVSTKIQTAQFKMRRNNIVLDEGMLQSLMELPEQFNYGMYAKFINDYGTHYITSGTMGGIYEYVMVLDKEKMKTEGTTVDEVQKCIGGGIGIGIKDSTIEGVGISGEFCENSGDGDRDIRKKITGVEDIISRVQGGSSVWGSVLTHNSSAITYQSWGRSLKYNPVVIDFEMQPIYQLLRHTNLGPLETKRQNLRRALDQYLMEFNACRCGPCFNNGEPILDGTNCRCQCSMGRQGLACERTVIEGLKDFKAAGHWSCWSSWSECRGGSQERRRQCNNPPPKNGGTPCLGRNLQTQAC
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MKIIVKTIQGILNEYEIEPETTTVGELKGMINAKQGIDIQNISLIYKSRMLKDNAQNLGGLGINEGDSIVMVVKKSAVPPPKLAPVTQPETHSTEPIQQPTTQPITTNQPSTQPVDIFQSQQRQTVNVEPTEENINHLVEMGFLRDDAIKALRKSQNNTAIAADFLISGVDLDNIPDQPAGSYEEYPQEPGSILNLTKDQFIELCREQPQIIESFIQHVESENPSAAQLIRNNPGMIYDIIKSQTNDNRVPSEPQHTQPQPNHAPSQPQLSPEDNAAIDRLCGLGFGRSQCLQAYIACDKNEQLAANFLLDGFD
The following text describes a protein:
Function:
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MFLGKAIILILWIFLAFTGLLAIQYYVPNPYLDEIFHIAQAQRFCRKDWDWDPAITTPPGLYLVSVALSPFIGCSNVSLRLINWLVGVIGLPWLINDIVSLLNNRKGDVVTYFAYTLSSLPPLWFFSFLYYTDIGSTFFVLLAYDFALRKSAFSSSVSCFFSLWFRQTNIVWMVFIAVTYFASNMSFFNPHLAEATFADVLLTIISFLGVFLKNLRRFSCPILSYGAVFCSFLAFLLWNGSIVLGDKSHHQASIHLSQINYFLWFFFFFSFPSYIIKYLMSHSRRSKLLSAVFSKKSFLIVSVLLLIAHFNTIFHPFILADNRHYLFYVFNRLFRIWWLKYLGPFSYLILYYFFLDISKLQMTSLTFFLLISTTILTLVPAPLVEFRYFLLPFLFWRFHLPLPSGRECLMEYALHMVINSVTLYIFLFRTFIWPSEPNALQRFMW
The following text describes a protein:
Function:
Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.
Sequence:
MFIASPVKTNLYGVGLVRSPAFPVLPRRLQHRVPLSRQVRAVISREEKAVDQEDEKSINRSVVYSSSPAFPWQRSKYTGTKTVMAVVKIRKKMREKLTERLGHQFELLMKAVGQGMLVQLVSEDIDPETGSGRRSLETPVLGLPKARNDPRNLEFTATFTVPTDFGKPGAILVTNLLSSEICLSEIIIRDGSDTILFPGNTWIHSRNENPEGRIIFRSQPCLPSQTPAGIKELREKDLRSVRGNGKGERKPHERIYDYDVYNDLGDPRKKDRVRPILGGPERPYPRRCRSGRTLVSRDPPCESRGKDKDEFYVPRDEEFEDIKRDTFTAGRLKALFHNLVPSIAAALSNLDIPFTCFSDIDKLYKCDIVLRPTEPKDTGLGGFFGSFVDGILNVGETLLKYDTPAVIKSDRFAWLRDNEFGRQALAGVNPVNIELLKELPIRSKLDPAVYGPQESALTEEVIAKEVLHYGMTLEQAFEEQRLFLLDYHDMLLPFVDKINSLKEDPRKTYASRTIFFYSKAGALRPLAIELSLPPTPDNENKFVYVHGHDATTHWMWKLAKAHVCSNDAGVHQLVNHWLRTHASMEPYIIATNRQLSTMHPVYKLLHPHMRYTLEINARARKSLINGGGIIESCFTPGKYSMELSSAAYKSMWRFDMEGLPADLVRRGMAEEDASEECGVKLVIEDYPYAADGLLIWKAIKNLVESYVKHFYSDTKSIASDFELQAWWDEIKNKGHYDKKDEPWWPKLNTAQDLTEILTNMIWIASGQHAAINFGQYPFGGYVPNRPTLLRKLIPQENDPEYEMFMRNPQYSFLSSLPTQLQATKVMAVQETLSTHSADEEYLIDLKENQRRWFQDEEVVKYFSKFSEELEEIEKKINKRNKDKKLKNRTGAGMPPYELLLPTSPHGVTGRGIPNSISI
The following text describes a protein:
Function:
Mediates water and glycerol transport across the cell membrane. Permeable to urea. Required for efficient progression of parasites through the liver stages.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop (By similarity). The two canonical Asn-Pro-Ala (NPA) motifs in the pore region, which are highly conserved in aquaporin water channels, are changed to Asn-Leu-Ala (NLA) and Asn-Pro-Ser (NPS), respectively.
Sequence:
MKVTFGNEYIKNFLGEFIGTFVLMFLGEGTTANHFAVPIKNDWLRLCIGWGLGVFFGILISAKLSGAHLNLAVTVGLSTIKKFNYKQIPLYFAGQLLGALSATASVYGLYYGFVSDQTIPKFSWETGKHANVHIASAFMHEFILTGILLLIILSVTDENICGKFHVLKVSSIVGLAIICIGISFGGNTGFALNPSRDLGARILSAIAYGFEAFTRDKCYFWIPLIAPIIGSIIFCQIYDKIVAPLVVISEHDKGALEI
The following text describes a protein:
Function:
Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Golgi apparatus.
Sequence:
MSNTHITDWSSKDGEFRRQVSSFRERISPEHKYFQPEKDRYHLYVSYACPWAHRTLIVRKLKGLENVIPVHVVGWLMGPNGWNFDKENDSTGDPLYNSPYLRNLYFRADPNYNMRFTVPVLWDSKYNTIVNNESAEIIRMFNDAFNEVIEDEEKRVVDLYPSSLRTKIDELNDYFYDTVNNGVYKTGFATTAEAYEKNVRVVFQGLDRLEQVLKESKGPFLLGDHLTETDVRLYTTIVRFDPVYVQHFKCNIGTIRHNYPHINQWLKRLYWKHPAFHETTDFKHIKCHYTQSHTQINPLGITPLGPIPNVEYF
The following text describes a protein:
Function:
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
Sequence:
MLLSRRIATRSGAVSRHLAARIQVTALRETRPHLQSGFHSSSKTAASTVLVSETRSPQAYVSLSTNPWFNLAFEDHLFRSVDPSIPICFLYRNSPCVVVGRNQNPWKELNATAMRSIGLPMVRRRSGGGTVYHDLGNTNYSFHIPRDDFDRRTHAELVARALNAAPVGLHLSRTDLARSDVGAYVNGRNDICIRVKRGFDRNSTTKTQAQADQLGFEERKVSGSAYKLVNKRAYHHGTMLLSASLRSLGSSLRNDRGELLVTKGVASVPAPVANLTDAFPDRTAMLSHEMFVQAVVAEFHRTYPDGCSTAAAVQVDESCLDAPQLNQGRWKLKENFDELQSWDWVFGQTPEFTHRVSMYDASELDSSQSRGWGPFSVEIHSKEGVVLDAKLVEARFDDGAVEREVQALIQGLQGRRYDDLALPPPWFPQSSSSSAAATVVDSATAIRAEEEPNIRAKLFHWLRTVL
The following text describes a protein:
Function:
Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Subcellular Localization:
Mitochondrion.
Sequence:
MDFLARQPLAFQVPAANVRVLRSPDEFYNTLLDNVRSAQRRIEFATLYMGVGPMEQKLIDAITERAAAKPDLRLRFLLDYTRGTRVDAQGRSSATALLHLAEQGRCALYHTPRLRSVARQLLRSPLNEIMGLQHMKLYVVDNKVIISGANLQEEYFTQRVDRYVMIEDEQLASFCADIIATVSRHSLYLRADGSITPSRYTKAHPAEDVKRHVRGMQRDLGRLVANYASEAKKKLFDLAATDMAVVAPVLQMGYYGVRYDQVFSQELSQVLRSEHRIQLSTGYFNLSPIYQKMLLAHQGAVTVLCASLEANGFLGARGAKGHIPYAYLHLLHGFQDAAAACKKTNLDVRQWRHEGWTFHAKGLHVFDALNRVVLATIGSSNFGLRSQELDLEFQLVMATNNSELQEAFNQEAKALLEDSTPVPSHEGAEKVKPWVKWISHQFGRYF
The following text describes a protein:
Function:
Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, microneme membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
The following text describes a protein:
Function:
Catalyzes the oxidation of alkyl nitronates to produce the corresponding carbonyl compounds and nitrites. Anionic forms of nitroalkanes are much better substrates than are neutral forms.
Sequence:
MHFPGHSSKKEESAQAALTKLNSWFPTTKNPVIISAPMYLIANGTLAAEVSKAGGIGFVAGGSDFRPGSSHLTALSTELASARSRLGLTDRPLTPLPGIGVGLILTHTISVPYVTDTVLPILIEHSPQAVWLFANDPDFEASSEPGAKGTAKQIIEALHASGFVVFFQVGTVKDARKAAADGADVIVAQGIDAGGHQLATGSGIVSLVPEVRDMLDREFKEREVVVVAAGGVADGRGVVGALGLGAEGVVLGTRFTVAVEASTPEFRRKVILETNDGGLNTVKSHFHDQINCNTIWHNVYDGRAVRNASYDDHAAGVPFEENHKKFKEAASSGDNSRAVTWSGTAVGLIKDQRPAGDIVRELREEAKERIKKIQAFAA
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MEKENSNPPMDHQSKEEAVIRDAVAPDVVDGSKQGALVRDAASTSADTVETGTQNATMFWDEVDEDDYWLQEEDLHAPLQDVEQVVNPWLDFLMASVAPETAALLRTIDANTNIFNVGAHVNTNNQLAALTRTAASATARRSAPVNATIFAGSSTEEEDGNEWYKSVARDAQRLEQMEDPELQEMSSSPSPLQLPGKSKAPPKDEHCSQMRPSAAAGEDGHELTLEDYCKIWGVHPSELEPDEPGPSTTKRQIRVPPLADDEVAKFDCGICLETLPILDLFHGTQCDHKFCAHCMATYIEGRIRDGVVSILCPDPACKEAAGEGNNGGVLNPEHCKKSIDFAAFCSWGERLTEKAIPQDQRAYCPNPRCALMLERTFVVGADKAACKAACPACNHPMCTACGLGWVIDGRDDDHHNCDEGKGAALVKELAAQRRWKQCPSCKIVVERIMGCDTMHCRCGSVFCYKCGRQMAPMDAELDEGAELCQCRDNVFRLHVPRRPLLLGAMHHQTNLNLN
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSVNAVTSLYRRSLKLALDWAVHRHIWRGQAVYIRSLFEANKNIRDPRQQKVLLRETEKLLETWKHPDPYRAPTAPGGSKYERNLPARQLPYASGGAGDH
The following text describes a protein:
Function:
This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. Also, involved in the degradation of oxidized and glycated proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MQTSSSATEAVRVYRDLARRPSVARAWINPAAKDVGTTDRKHVEVCSLWAQRDIETSKTAKFIRSHKISMTDRGVASSEVSGAPVDTSTCQLQQTSPSGKLSAVVRLLSDKQYLEIWDHTCKLKNVELQALEKHGKVYDDGTFGCFQWSPCERYLLYIAEKKTPKMESFFKRKDKGKAESGDAPVQGEEFVYQEDWGEGLVAKHHPVLCIFDIEEETTQVLENVPDEVSPGQAVWCPDGKGVVFVGWWHVPFRLGIIYCTNRRSALFHLDLDGRTCKQLTGDDLSVRCPRFSPDGSRLVYLQNPPGGPHSSCSQVAMYLWKEKTAVVVTDIVRQVSGDGFPGMYTWDTEIVAMYLWKERTAVVVTDIVRQVAMYLWKEKTAVEVTDIVRQVSGDGFPGVYTWDIGFLQCWAADSRRVVLHTNWRSRMALIIINTDTNEVKKLSAEGDVTAAAWRLLDIRDDLILAACSAPNTSQHLRCAVLPPAGQEHLVKWETLDVEVPTLTPPLDHKVITLTPADEGMEYEAILMRKRGVESPPMIVWPHGGPHSVFSSEFLPFTVGLCQLGFAVLLVNYRGSLGFGQDFVESLPGKVGTQDVSDVQHAVETIVGTEGVNKNQLFVCGGSHGGFLVTHLIGQFPDTYKACVARNPVINIASMFGITDIPDWCCVEAGVEPDYHKPPSPEVYTAMLTKSPMFHASKIKAPTMIMLGEVDRRVPHTQGKELYRLLKTRGVPARLLVYPDNNHPIAKVDAEADAFVNIYKWFTEHMATV
The following text describes a protein:
Function:
Component of the transcription regulatory complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. The SAGA complex predominantly acetylates histone H3.
Subcellular Localization:
Nucleus.
Sequence:
MQTEHWGSLPAEDDGGQLTPDKYVPTAAKKLKLDEIRQRGDPQPQEKHHKLELRSALVTQTIEVMKQTEVLQSLIETYSNKNGSSNYLLNPCLMIPEVDFPPENAAELVGSQKFQKPIWFTPTVDTAYSRGDPEAYPEIPSSACRQAMRKVMCGMLRLAGFTDCSESAVQLLTDATEEFLRSFIGEYRGYYDSQPRLQNSTVLQLVPLERAHFAQTGTSLTQVHNYYKHKVLARNRAEIAEFNSVLQEYDKLMKESQSSMQKQHNEFNGHDFLNILDNSATGSSQSIGGMAMGDMLQDLGGSTGSSGTVSSQQMLYGLLDGQISSNTSNMTGTSGNGSTGGNGNGNGATISNFHATFET
The following text describes a protein:
Function:
May be involved in early development in cAMP sensing and subsequent chemotactic response. Probable receptor of GABA and glutamate, leading respectively to the induction or inhibition of SDF-2 formation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKIKIGNILKNVVILVIFSLFISKINSEVVKPNPAKPDELVIAFMSPYFDPEYTQYSGAAEYALSKFNETFKTKYSKTIKLHTFTDTNDVIDSLDLVTMPVNGIVGPAYSGSSSTACLVFGAFAVPSISFYATGASLSNSGSYPYFQRVMPDDRLQVQAILSLLKKNGWTRVSCIHTNEDYGNGGADQLVQQSNAQGITVNTNQAIDPVDNGIAPEQLYYDIVFDNLEAAKSRVIVLYALFPPDCLEIWKQAKARGFLGEGFTWIVTDGCAELTGGTDPDLLGVLATFPSYGLGTEAYTDFERTIVNDYNNNTGDAFYKGASFSYDATYAMLMGIEAVLAKGGDPWDGEQVRTELRNLKFNGITGTIAFDKNTGDRLYGEFALLNLINSTKGSFDPIGKINPDSGEITLKSDILYSGPTYKVPSDYQVVVFDRTLNIVLGVITGVCVLIVIGIGSVIALQWRKFRYSSPLFCMFIIIGALMGLASVFTLLPTPTTPLCSGFPWLLGLGYVIVFGTLFTKTWRTWRLFSNARKFKIIRITNKFIITLVGGFVLLESIFMIIWTAVDRPIPLAEPIFKAGEAQLQCTSDSEAWWYVFVFYKVFYILFGVFLAFKTRNVVDSLNESKPITLALYNLTFVMVVAIALGFILRDNPIAIIVIQTIAILLGFTVTVSVLFLPKVWMILSGQQHSMDSIGTSMDSMGRSNGNTTEAESTRGYTNKDYNNQSVGRSFSAHATGFKDVAPSNHPQLGIVYTGGDNFPRVGSSQTAASRSEAEINVSKDVLAKANKKNEEEFGEFFLKPSEDNILKKKKKKKNNNK
The following text describes a protein:
Function:
Transcriptional repressor that regulates multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing OFP6 show flat, thick and cyan leaves, and enhanced apical dormancy.
Subcellular Localization:
Nucleus.
Sequence:
MATKSKKKILKTVSVVDISCGNCIKPTFASIFNFFSKKPKRPSSTYRHCHSSISSATPSSTPLATASVAVEKDSDDPYLDFRQSMLQMILENQIYSKDELRELLQCFLSLNSHYHHGIIVRAFSEIWEDVSSAAASAVEASPLITRHVSRASRDYYNYY
The following text describes a protein:
Function:
Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
Subcellular Localization:
Nucleus.
Sequence:
MARSESPPARKRRDSSTSSSSASGADSDSSNSSKEAVPSKKSKMSASPPSKRKSSPPSRFRDDRRRSRSPPPRRDDRRDDRRRDDRRRDSPPRRDRRSPPRRSRSPRRERSPPRRGQSPRRVRGEDRDRRDRSRDRDRRRSPARNDRGDQFGLTRRDTKRDVKEEHGSPQQSQLMRARDKRRNEEGEGGGKQKWGTKEMWDEEERKKKEKEEGPPKDKEKVNMGTSGLLAQDTNTFNGVVIKYNEPQDAKIPNIRWRLYQFKDGDDSLPCLYIHRQSAYLIGRDRKIADLPVDHPSCSKQHAVLQYRSVAFEKADGSRARRIRPYIIDLASANGTFLNGKKVDASRYIELKEKDVLKFGFSSREYVLLTENALEHEAKESSSDSSDVSSDEEDDGVKKEVKEEED
The following text describes a protein:
Function:
Thyroid hormone-binding protein, with a much higher binding affinity for triiodothyronine (T3) than for thyroxine (T4). Probably transports triiodothyronine from the bloodstream to the brain; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Subcellular Localization:
Secreted.
Sequence:
MAQCVEQATFSETCSLGLELSVCSPAVSFKVFSCRRVLEETQAVLKKGLILTQVHGHSSHGETDSKCPLMVKVLDAVRGIPAGNLLVNVFRQTDGNWELITSGKTTELGEIHNLTTDEQFTEGVYKIEFATKAFWGKLGLSPFHEYVDVVFTANDAGHRHYTIAVMLTPYSFSSTAIVSEPHDDLQ
The following text describes a protein:
Function:
Together with AXS2, catalyzes the conversion of UDP-D-glucuronate into a mixture of UDP-D-apiose (UDP-Api) as the main product and UDP-D-xylose to a lesser extent, via a cycle of oxidation and reduction. D-Apiose (3-C-hydroxymethyl-d-erythrose) is the only plant cell wall monosaccharide with a branched carbon skeleton and is found in rhamnogalacturonan II (RG-II), apiogalacturonan, and several apioglycosides.
Subcellular Localization:
Cytoplasm.
Sequence:
MANGANRVDLDGKPIQPLTICMIGAGGFIGSHLCEKLLTETPHKVLALDVYNDKIKHLLEPDTVEWSGRIQFHRINIKHDSRLEGLVKMADLIINLAAICTPADYNTRPLDTIYSNFIDALPVVKYCSENNKRLIHFSTCEVYGKTIGSFLPKDHPLRDDPAFYVLKEDISPCIFGSIEKQRWSYACAKQLIERLVYAEGAENGLEFTIVRPFNWIGPRMDFIPGIDGPSEGVPRVLACFSNNLLRREPLKLVDGGESQRTFVYINDAIEAVLLMIENPERANGHIFNVGNPNNEVTVRQLAEMMTEVYAKVSGEGAIESPTVDVSSKEFYGEGYDDSDKRIPDMTIINRQLGWNPKTSLWDLLESTLTYQHRTYAEAVKKATSKPVAS
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVPETEGSCGPPTSHIPEAMNSVSPSAAQYRAGAQQEDLLPPAGRRPPRDPRNYFGNDEPDEVDRLKAKLMSAWNNVKYGWSVKMKTSFNKTSPLILLGRIYVLNDEDEVERFQRDFVSRVWLTYRREFPQLEGSVWTTDCGWGCMLRSGQMLLAQGLLAHLLPSEWTWPGAHQLADVDMEVLKPRSPSRGGLFPGPPLSRAPCQTPRGHGSGVEGSGRRAPPGHSQDPHSEAVHRRVVSWFGDHPHAPFGVHQLVELGKSSGKKAGDWYGPSIVAHIICKAVANATDIRNLAVYVSQDCTVYKGDVARLCEQGVTEGLSAPSPSWKSVIILVPVRLGGETLNPVYTECVKSILSLDCCIGIIGGKPKHSLYFIGFQDEQLLYLDPHYCQAVVDVTRDHFPLESFHCNSPRKMSFSRMDPSCTIGFYARSRKDFETLCSAVTAALASSPMEKYPIFTFAEGQSQDYVLGEHAGMPSAHRGCILPAGHLSRTHGGSMDDFVLL
The following text describes a protein:
Function:
Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MDALKVQILPDNQSSPSSTHMLTKPKSKKATKSIAMLIVASLAITLGLLFVFSSNSVMFSASFLRRSSLHYSVIIDAGSSGTRIHVFGYWFESGKPVFDFGEEHYASLKLSPGLSSYADNPEGASVSVTKLVEFAKGRIPKGKLKKSDIRLMATAGMRLLDVPVQEQILDVTRRVLRSSGFKFQDEWATVISGTDEGIYAWVVANHALGSLGGDPLKTTGIVELGGASAQVTFVPSEHVPPEFSRTISYGNVSYTIYSHSFLDFGQDAAEDKLLESLQNSVAASTGDGIVEDPCTPKGYIYDTHSQKDSSGFLSEESKFKASLQVQAAGDFTKCRSATLAMLQEGKENCAYKHCSIGSTFTPNIQGSFLATENFFHTSKFFGLGEKEWLSEMILAGKRFCGEEWSKLKEKYPTTKDKYLHRYCFSSAYIISMLHDSLGVALDDERIKYASKAGKENIPLDWALGAFILNTDTPTSDYNGKSRKMIGFK
The following text describes a protein:
Function:
Involved in sporophytic self-incompatibility system (the inability of flowering plants to achieve self-fertilization), probably acting in combination with S-locus-specific glycoproteins. Interaction with a ligand in the extracellular domain triggers the protein kinase activity of the cytoplasmic domain.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MKGARNIYHHSYMSFLLVFVVMILIHPALSIYINTLSSTESLTISSNKTLVSPGSIFEVGFFRTNSRWYLGMWYKKVSDRTYVWVANRDNPLSNAIGTLKISGNNLVLLDHSNKPVWWTNLTRGNERSPVVAELLANGNFVMRDSSNNDASEYLWQSFDYPTDTLLPEMKLGYNLKTGLNRFLTSWRSSDDPSSGNFSYKLETQSLPEFYLSRENFPMHRSGPWNGIRFSGIPEDQKLSYMVYNFIENNEEVAYTFRMTNNSFYSRLTLISEGYFQRLTWYPSIRIWNRFWSSPVDPQCDTYIMCGPYAYCDVNTSPVCNCIQGFNPRNIQQWDQRVWAGGCIRRTQLSCSGDGFTRMKKMKLPETTMATVDRSIGVKECKKRCISDCNCTAFANADIRNGGSGCVIWTERLEDIRNYATDAIDGQDLYVRLAAADIAKKRNASGKIISLTVGVSVLLLLIMFCLWKRKQKRAKASAISIANTQRNQNLPMNEMVLSSKREFSGEYKFEELELPLIEMETVVKATENFSSCNKLGQGGFGIVYKGRLLDGKEIAVKRLSKTSVQGTDEFMNEVTLIARLQHINLVQVLGCCIEGDEKMLIYEYLENLSLDSYLFGKTRRSKLNWNERFDITNGVARGLLYLHQDSRFRIIHRDLKVSNILLDKNMIPKISDFGMARIFERDETEANTMKVVGTYGYMSPEYAMYGIFSEKSDVFSFGVIVLEIVSGKKNRGFYNLDYENDLLSYVWSRWKEGRALEIVDPVIVDSLSSQPSIFQPQEVLKCIQIGLLCVQELAEHRPAMSSVVWMFGSEATEIPQPKPPGYCVRRSPYELDPSSSWQCDENESWTVNQYTCSVIDAR
The following text describes a protein:
Function:
Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles. Regulates autophagy and pyroptosis, but not apoptosis.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Nucleus outer membrane; Peripheral membrane protein.
Sequence:
MVCGGPTEMGYPRFLRIVLPLALLFLFLYLSVTKLPDVHLHECLQDGKPCRQIPNDVIEDIRVKPSASLKLDPSDVQLLENVMKNCKQHEFQIGRMVEAFRYCMTEKKDILLEEYLIAWRQLIKFMDALGTVFTFISSETMTKVNILQGYLNGEHGKDYRTVTSMVKYELENEVVNFKELPPNRVPSGCRTLLRLHRALKFLEVFLYNLGMSVGKDKTSQMCADAYHKTLSHHHSWFIRQVAEVAFLALPPIEDMYKVVCVSNHKDAKIVLLTTVDAIVKVYNITQEVYTKHGMLDLP
The following text describes a protein:
Function:
Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is atypical: it cannot load onto its tracking strand internally and has an absolute free 5'-end requirement. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.
Subcellular Localization:
Nucleus. Chromosome. Note=Recruited to double-strand. break (DSB) sites following phosphorylation at Ser-17 and Ser-237.
Sequence:
MPGTPQKNKRSASISVSPAKKTEEKEIIQNDSKAILSKQTKRKKKYAFAPINNLNGKNTKVSNASVLKSIAVSQVRNTSRTKDINKAVSKSVKQLPNSQVKPKREMSNLSRHHDFTQDEDGPMEEVIWKYSPLQRDMSDKTTSAAEYSDDYEDVQNPSSTPIVPNRLKTVLSFTNIQVPNADVNQLIQENGNEQVRPKPAEISTRESLRNIDDILDDIEGDLTIKPTITKFSDLPSSPIKAPNVEKKAEVNAEEVDKMDSTGDSNDGDDSLIDILTQKYVEKRKSESQITIQGNTNQKSGAQESCGKNDNTKSRGEIEDHENVDNQAKTGNAFYENEEDSNCQRIKKNEKIEYNSSDEFSDDSLIELLNETQTQVEPNTIEQDLDKVEKMVSDDLRIATDSTLSAYALRAKSGAPRDGVVRLVIVSLRSVELPKIGTQKILECIDGKGEQSSVVVRHPWVYLEFEVGDVIHIIEGKNIENKRLLSDDKNPKTQLANDNLLVLNPDVLFSATSVGSSVGCLRRSILQMQFQDPRGEPSLVMTLGNIVHELLQDSIKYKLSHNKISMEIIIQKLDSLLETYSFSIIICNEEIQYVKELVMKEHAENILYFVNKFVSKSNYGCYTSISGTRRTQPISISNVIDIEENIWSPIYGLKGFLDATVEANVENNKKHIVPLEVKTGKSRSVSYEVQGLIYTLLLNDRYEIPIEFFLLYFTRDKNMTKFPSVLHSIKHILMSRNRMSMNFKHQLQEVFGQAQSRFELPPLLRDSSCDSCFIKESCMVLNKLLEDGTPEESGLVEGEFEILTNHLSQNLANYKEFFTKYNDLITKEESSITCVNKELFLLDGSTRESRSGRCLSGLVVSEVVEHEKTEGAYIYCFSRRRNDNNSQSMLSSQIAANDFVIISDEEGHFCLCQGRVQFINPAKIGISVKRKLLNNRLLDKEKGVTTIQSVVESELEQSSLIATQNLVTYRIDKNDIQQSLSLARFNLLSLFLPAVSPGVDIVDERSKLCRKTKRSDGGNEILRSLLVDNRAPKFRDANDDPVIPYKLSKDTTLNLNQKEAIDKVMRAEDYALILGMPGTGKTTVIAEIIKILVSEGKRVLLTSYTHSAVDNILIKLRNTNISIMRLGMKHKVHPDTQKYVPNYASVKSYNDYLSKINSTSVVATTCLGINDILFTLNEKDFDYVILDEASQISMPVALGPLRYGNRFIMVGDHYQLPPLVKNDAARLGGLEESLFKTFCEKHPESVAELTLQYRMCGDIVTLSNFLIYDNKLKCGNNEVFAQSLELPMPEALSRYRNESANSKQWLEDILEPTRKVVFLNYDNCPDIIEQSEKDNITNHGEAELTLQCVEGMLLSGVPCEDIGVMTLYRAQLRLLKKIFNKNVYDGLEILTADQFQGRDKKCIIISMVRRNSQLNGGALLKELRRVNVAMTRAKSKLIIIGSKSTIGSVPEIKSFVNLLEERNWVYTMCKDALYKYKFPDRSNAIDEARKGCGKRTGAKPITSKSKFVSDKPIIKEILQEYES
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MADNGVNTKVEAVSEASTETIELITEDGGVFDVDKPVAMEFLILKSFYEDEDRVFDKTSIRLPNVKQLELSKVIEYCTRALEFGAKSAAAAGDKDAERMVRQEREGFEAEFVDKLSNEMLKELILAVNFLHVKEMLDFLIRSVANRIRNRSVAYVRQFFDIENDFTPQEEDQIHQENAWAFEGVDAD