lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Low affinity heme transporter involved in the assimilation of exogenous heme during conditions of low cellular iron.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEAKETHSISDHEVELQDAKPEEKSENGNFVFEKAFSSDEEKGSGYNTNETYSKMDNSLQHRGVSKIEAVRDSIYQNKRGMYLAYAFGIAILACSWASAIQSSTTYSYQVYATASFNRTSMISTLEIATAIISSVCKPILGKFSDITSRPMTYTLVLLFYVIGFIVVASSSTISAYVIGSVFISIGSSGLDYLNTLVVGDLTSLKWRGFMTALLSTPYIATVWFTGFIVQGIIDSNWRWGYGMFAIIMPAVMTPAVIILMYLERQANKDENIKKIINYQTEEKNKNKQSKWQKLWKAVLEVDLFGLILLGVGWSILLLPFSLTSYAKNGWKNPSMIAMMVVGGVILIAYSGYEMFIAPYPSCPRRVMNRTFITAVIIDFFYYLAGYLQSMYFTTYTWILYDWSYRDWTYFNNTMTIALCVFGVFAGAMHRVFHRYKYLQIIGLVIKIVGYGILIRPNFAATGKVDLAWSLILIGMGGSFSVVGSQVSCQASVPHQDLAIASSLLPLYTNIGGAIGAAIASPIFSNKVPKYLREYLPSSINDTQVYNFYSDSSLIREYPVGTEIRDGAIKAYSRSMFFLLVPAVSLSFIPLAAAFWQSNFYLGNQQNAVEGDQDHKKKGDKETTQEEKIII
The following text describes a protein:
Function:
Phosphorylates both NADH and NAD(+), with a twofold preference for NADH. Anti-oxidant factor and key source of the cellular reductant NADPH.
Miscellaneous:
MISCELLANEOUS: Present with 4650 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MFVRVKLNKPVKWYRFYSTLDSHSLKLQSGSKFVKIKPVNNLRSSSSADFVSPPNSKLQSLIWQNPLQNVYITKKPWTPSTREAMVEFITHLHESYPEVNVIVQPDVAEEISQDFKSPLENDPNRPHILYTGPEQDIVNRTDLLVTLGGDGTILHGVSMFGNTQVPPVLAFALGTLGFLSPFDFKEHKKVFQEVISSRAKCLHRTRLECHLKKKDSNSSIVTHAMNDIFLHRGNSPHLTNLDIFIDGEFLTRTTADGVALATPTGSTAYSLSAGGSIVSPLVPAILMTPICPRSLSFRPLILPHSSHIRIKIGSKLNQKPVNSVVKLSVDGIPQQDLDVGDEIYVINEVGTIYIDGTQLPTTRKTENDFNNSKKPKRSGIYCVAKTENDWIRGINELLGFNSSFRLTKRQTDND
The following text describes a protein:
Function:
Induces vacuolation of eukaryotic cells. Causes ulceration and gastric lesions.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein. Cell surface. Periplasm. Secreted.
Sequence:
MEKTHRKINRPLVSLVLAGALISATPQESKAAFFTTVIIPAIIGGIASGVAAGTASGLLSWGLKQAEQANKAPDKPDKVWRIQAGRGFDSFPNKEYDLYQALLSNKIDGGWDAGNAARHYWVKGGQWNKLEVDMKNAVGTYKLSGLRNFTGGDLDVNMQKATLRLGQFNGNSFTSFKDGANRTTRVNFNAKNISIDNFLEINNRVGSGAGRKASSTILTLQASEKITSRENAEISLYDGATLNLVSSSNHSVDLYGKVWMGRLQYVGAYLAPSYTTIDTSKVKGEVNFRHLTVGDHNAAQAGIIASKKTNIGVLDLWQSAGLNIIAPPEGGYKDKPNNTTQNSANNSQQDSAQNNNGTSVINPPNSAQKTEIEPTQVINSTFAGGRDTVVNIFHLNTNADGTIKIGGYKASLTTNAANLNIGEGGINLSNQAGGRTLVVENLTGNITVNGALRVNKESGGAALPGSSANFEFKAGVDTNNATATFNNDIRLGKAVNLKVDAHTINFNGNMVLGRFTHLKVNGHTANFKDIDASKGRNGINTTILDFSGVTNKVNINKLTTAATNAAIKNFDIKELVVTTNGLSVGKYTDFTEDIGDQSRIGIVRLERGYSPLYAGGVRFKSGKKLVIDEIYHAPWNYFDARSITDVEITKKILFGAPGYIAGKTGLMFNNLTLNSNASMDYGKDLDLTIQGHFTNNQGVMNLFVQDGRVATLNAGHQASMIFNNVVDSATGFYQPLIKINNAQNLTKNKEHVLVKARNIDYNLVGVQGASYDNISASNTNLMEQFKERLALYNNNNRMDICVVRNTDDIKACGTAIGNQAMVNNPDSYKYLEGKAWKNTGISKTANNTTIAVNLGKNSTPTNSSTDTTNLPENKIKNARFISYALIKNAPFAQANATPNLVAINKHNFGTIESVFELANRSKDIDTLYANSGAQGRDLLQTLLMDNHDAGYAREAIDKTSVGEITKQLNEATTTLNNLASLERKTNGLQTLSLSNAMILNSRLVNLSRKHTNNIGSFAKRLQELKDQKFSSVESAAEVVYKFAPKYEKSTNVWANAIGGASVNSGSNASLYGASTGVDTYTSGNVEAIVGGFGSYGYSSFNNQANSLNSGANNANFGVYSRIFANQNEFDFQAQGAVGSDQSSLNFKGALLQGLNQNYNYLAYSAMANASYGYDFAFFKNAFVLKPSVGVIYNHFGSTNFESNSTSKAALSDGASSQHLFNANANIEARYYYGDTSYFYLHAGVLQEFANFESHNAVSLNTFKVNAARSPLSTHARVMMGGELKLAKEVFLNLGFIYLHNLISNAGNFASNLGMRYSF
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Sequence:
MAANLEDVPSLDLMHELLRRMKCSSKPDKHLILIGPPGSGKGTQSPLIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDGLVVGLIDEAMKKPSCQKGFILDGFPRTVTQAQKLDEMLAKQGANVDKVLNFAIDDAILEERITGRWIHPASGRTYHTKFAPPKSPGVDDVTGEPLIQRRDDTAEVLKSRLEAFHRQTEPVIDYYSKKGLVANLPAEKPPKEVTAEVLKALS
The following text describes a protein:
Function:
Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
Subcellular Localization:
Preautophagosomal structure membrane; Multi-pass membrane protein.
Sequence:
MTFPNVTWRDIYNYYYQRGLKSFIINSISNIVIGLFIAFSPVLLFRCIDISKINTTTKISDVIRPFSEGWKRSNLFIECCVVIFSIYVLIQILQFAYTLPTFIRIWKYFKETLEIKDVDLYVLDWIEILDAIAQKDSTVRISSLEIAQEILRMENYITAFVTDPELLTWKLPYMNQACHFPMTRFFFYIFQISLNGTVMDSTGASIVSDVPDIRLPQVRDSLSKRFKVIGFILFLISPFYLAFQALYLIFHYFQSVKSSPSSLSMRRWSPEAKWAIREYNELPHLFNERLQRADYFSNLYIEQFPPDAMQTVYKTVCFLCGSFIAYFIFIGLFSDVSIVFGALIGQKSIVWVMALLATIYSIFNGLIKKKKKSKDSLELYEEIRKFIHYDFTDENHNALSWEAQSKFTEFFQPLWLHIVIELCGCIINPVVFTFVLPLHSEKIIDFVRKNSVRNENIGCICRFSNFEDVINGGNVAQNGKIKRSISNFKLYGQQSIRKDQPNLIQFDADEMQALVDSNQPAATLMEPSLTDVRSMLPPPSYPRF
The following text describes a protein:
Function:
Hydrolyzes acetyl esters in homogalacturonan regions of pectin. In type I primary cell wall, galacturonic acid residues of pectin can be acetylated at the O-2 and O-3 positions. Decreasing the degree of acetylation of pectin gels in vitro alters their physical properties.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MAPRRRRAWPAAAAVVTAVVTAAAAVVFAAQAADMVQERLTVGMTIVADAAFTGAVCLDGSPPAYHLHRGSGAGARSWLLQFEGGGWCNDVRSCAERAGTRRGSTHLMTKVEVFSGILSNLPAMNPDFYNWNRVKLRYCDGGSFSGDSAYINDSSVLYFRGQRIWDAIITDLLQKGLAKAENCKSEIHFFYAFKSWVCVLQVLLSGCSAGGLATFFHCDSLKERLGGATTVKCLSDAGFFLDLNDISGINNIRQFFSSLVSVQGVQKNLNKDCQNSTDYPYLCFFPQYALPYIRTPYFILNSAYDVYQFHHIFVPPSSDPRGQWSRCKMDPGACSTSQIATLQGLRNAMLTSLKQIEGEPEAGMFINSCFAHCQSELQDTWFAPDSPMIHDRKIAEVIGDWYFERDAAKEIDCAYPCDSTCHNLIPSDQELRMY
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
MVERLSTDKSVLQHQDTNSFRPFCASGYPFSPSSCGINTDSFHVGGYEHAVDTPSSYRSSTDTLSFEEVYHGMRYDDMFYHGNGVPSLPQHYGDLHADDVNYFAPFRSSNQQYPLPEPLHASPEFHMSQTNSTHPYRHGNEINSFETDYMMRSTRNFGLRNNIFGKPKLNPFTGRRTFLPMASTTRSMKHSISADLSANDFDMGSPSRFLQDDFGSSASLTYREQAYNQCKRGSFSASSSSPSSPWELDYIFPPLDESTSGSCSDFYHRPAMSDLLTERNRGPRASRPNAKSKMITYDQQDLLSQFRDAKFFVIKSYSEDNVYKSMKYCVWASTKNGNKKLDAAYREAKTKEVACPVFLLFSVNASAQFCGVAEMVGPVDFETSVEYWQQDRWSGHFPVKWVIVKDVPNSLFRHIIIEDNDNKPVTNSRDTQEVGVEQGIEMINIFNSCEMKSSILDDFSFYEERQRIQDRKARQRALLEPLRASSLTSVPTHLASSLHEDYVREMSKSFADALVLQHKLN
The following text describes a protein:
Function:
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSTMSYGHPTPVLLTSTLIPISLLLILNPLLPLILPALPPPIESIISNVPLPKQPTLPALQANIGFALLAFVGAVWIVPRVSGAFVEKGLRGRDLLKPGGRTSGPWIPESLGLPCASWYIALMMLFIPFPFSHLFQGGMLEVFPQRELTLYLSSLLSLLTATLLGFIDDLFDIRWRHKLPIPIVAAVPTLLVYYSVGGATSVVLPQGVVGWARTMGMGEWVDNGVVDLGPLYYIYLILLPTFTTNSINILAGINGVEVIQALLIALSVILNDLLFLPIWPERFLRLLGVDQPENGRVLEWAIGEVVDRHLMSLYFMAPLAGVCAGFLWHNWYPARAFPGDTFCYFTGMAFSAVAIQGHFSKTLILFFIPQIFNFVLSCPQLFGLVDCPRHRLPAFDAETGLLHPSRVTFENPPPTKTRITLQILEFLRLVRLERSKSSRGDQQIHIKSSTNLTILNFLLVHFGPMREQTLCALVAGVQILGSAVAFGIRYGVGSWFYGGDRR
The following text describes a protein:
Function:
Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MADQTNPWDTAQVADTTTQTADAWGTPAGVATDGGSTDWLNSAPAPAPEHFSLLDPFHKTLIPLDSWVTEGIDWVVTHFRPLFQGIRVPVDYILNGFQQLLLGMPAPVAIILFALIAWQVSGVGMGIATLISLIAIGAIGAWSQAMITLALVLTALLFCVVIGLPMGIWLARSPRAAKIVRPLLDAMQTTPAFVYLVPIVMLFGIGNVPGVVVTIIFALPPIVRLTILGINQVPADLIEASRSFGASPRQMLFKVQLPLAMPTIMAGVNQTLMLALSMVVIASMIAVGGLGQMVLRGIGRLDMGLATVGGVGIVILAIILDRLTQAVGRDSRSRGNRRWYTTGPVGLITRPFVK
The following text describes a protein:
Function:
Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation.
Miscellaneous:
MISCELLANEOUS: Present with 3130 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus, cis-Golgi network. Endoplasmic reticulum. Preautophagosomal structure.
Sequence:
MAIETILVINKSGGLIYQRNFTNDEQKLNSNEYLILASTLHGVFAIASQLTPKALQLTQQTNIENTIPYIPYVGMSSNRSDTRNGGGNNNKHTNNEKLGSFKGDDFFKEPFTNWNKSGLRQLCTDQFTMFIYQTLTGLKFVAISSSVMPQRQPTIATTDKPDRPKSTSNLAIQIADNFLRKVYCLYSDYVMKDPSYSMEMPIRSNLFDEKVKKMVENLQ
The following text describes a protein:
Function:
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.
Subcellular Localization:
Nucleus speckle.
Sequence:
NTDLNNSIEIAANEKQTKARKVKRPPNCFFVFGEVMRPGVIAQNPRANLTEINKKLGFMWKELTEEERQRYKAEADRRKFEHSILNPGYVYRPKRKRSVENVITNR
The following text describes a protein:
Function:
Removes uracil from G/U mispairs in ssDNA. Also corrects G/G mispairs. Does not catalyze the removal of thymine from G/T mispairs.
Subcellular Localization:
Nucleus.
Sequence:
MNDIETRDTGTKNDNSSEFNLSVKSHKRKRSFDDENLELEESREETSGGILKKAKTQSFSESLERFRFAHAGSNNEYRKTDVVKNSDTDNGLLKSAVETITLENGLRNRRVNVTKKSTLKASVKKSTLKKKNEVDPALLQGVPDYICENPYAIIVGLNPGITSSLKGHAFASPSNRFWKMLNKSKLLEGNAEFTYLNDKDLPAHGLGITNLCARPSSSGADLRKEEMQDGARILYEKVKRYRPQVGLFISGKGIWEEMYKMLTGKKLPKTFVFGWQPEKFGDANVFVGISSSGRAAGYSDEKKQNLWNLFAEEVNRHREIVKHAV
The following text describes a protein:
Function:
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
Sequence:
MTERKYFGTDGVRAVAGEFPLTPAWVMALGAAAGEVFKRRNPRASVVIGKDTRQSGDMLEAALAAGLTSRGVNVVHLGVLPTPGVSYLTRHLGAEAGVVISASHNPYEDNGIKFFGPGGGKLSDATELEIEAAIDEAATLAPVTGVNLGSVTNYTEAERLYTAFLSSHAPDLSGMRIALDCANGAAYRVAPKVFQQAGADVFAVYTTPDGRNINRGCGSTHMDHLRLIVREGDYDLGIAFDGDADRALFVDSRGNMIHGDHMLLLSARARGEKAVVATIMTNMALEVKLQEAGLTLERTAVGDRYVHERLHAKGLNLGGEQSGHVLFLDVSPTGDGVLTALLTLSSMKKLGTTLDALYDELVMFPQTLVNVRVKDKKAIASDPAVQHAVADAEKQLAGKGRINLRPSGTENLIRVMVEGQDEGEIHDIAAAVAKVVEERGAAGA
The following text describes a protein:
Function:
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Subcellular Localization:
Cytoplasm.
Sequence:
MLELIIGGFFGDEGKGKVAAYLGIKDRPKLSVRTGSINAGHTVTYSGRIWKLRIIPSAFINKSTELALGPGALTSLDALFKEMRETETYDRLYIDSHVGIITEDEIRDEKNDPYLMNVIGSTGQGVGYAESKRILRKLKLAKDYKELEKFIIDVPNKILDYLDNGHNILIEGTQGHYLSLYHGEYPYVTSRNTTASGVLSEAGIGPKYVDHIIITFKSYVTRVGKGPLEGELTEEDAKKLGLTEYGTVTGRLRRVAPFNVKLAREAIRINSATIVAITKLDTLFKDAYRVREYEKLPAEARKWLDELEEELKTPIGLIGTGEDAYDMIDLREEVG
The following text describes a protein:
Function:
May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.
Subcellular Localization:
Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSCSVTHTVSFSLPFLNFSHPASTPQLTENEQPSLVWFDRGKFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGITRHFATNPAPAALTFRVMNFSRLEHVLPNPQLLCCDGTQTDASTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVSWRCEPTSTDLRIDYKYNTEAMTTPVALNNVQFLVPVDGGVTKLQAVLPPAVWNAEQQRILWKIPDISPKSENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGGGYRFSLIKKRFAAGKYLADN
The following text describes a protein:
Function:
Acyl-CoA ligase; part of the inp gene cluster that mediates the biosynthesis of fellutamide B, a mycotoxin that acts as a proteasome inhibitor. In the first step of fellutabmide B biosynthesis inpC activates 3-hydroxydodecanoic acid to generate 3-hydroxydodecanoyl-AMP that is then loaded onto the T0 domain of inpB. The 3-hydroxydodecanoyl-S-phosphopantetheinyl-T0 is sequentially extended with L-Asn and L-Gln by the two CAT modules of inpB. The linear lipodipeptide from inpB is then transferred onto inpA for the addition of the third amino acid, L-Leu. Reductive releasing of the lipotripeptide by the TE domain of inpA produces (2S)-fellutamide B. InpF might be involved in the release and transfer of the lipodipeptide from inpB to inpA. The inp cluster-encoded proteasome subunit inpE confers resistance to internally produced fellutamides. The MFS efflux transporter inpD may contribute to fellutamide resistance as well.
Domain:
Both substrate-binding domains (SBD1 and SBD2) are involved in the substrate recognition, and are sufficient to confer the substrate specificity.
Sequence:
MIFTPPVWGPEMMAIPASRPIHEFLVERDSRHLYDWSEEKPALTIADRVDALARSLGRELGWSPNTGSPWSKVVGIFSFNTLDFLVASWAIHRIGGICMLMHPTSSAAEIKRHIELTECRVLFTCRSLLPTANEVLVASKVQDPRAYLLDLPEELGRKPSLPDQGQQTVEQLISAGATLPLIEALDWAEGQGKEQVAYLCPTSGTSGLQESALTVKKLAMITHYNIIANIIQATTFEAGPKKGRTEVALGFLPLSHSYGLILAHLTAWRGDTYILHARFDMQAALASIEKYRIERLYLVPPIISALVNNPFLLDLCDTSSVTSVVTGSGPFGPRLAEALSRVRPSWQVLPGYGLTETAVIISITDPNITYPGADGCLVPGVEARLINSNGNEVEAYNEPGELLLKSPSIMKGYLGQETATREVFDEQGWLRTGDIAVFRLTGQDGKVTPHLDIVDRKKDIMKVKGLQVAPVEIESHLAAHPAVAEVAVVGVRDEDAGERPYAFIVRSPRTMADLDEEALKADLNRHVEATLSEPHWLRKNIRFVEEFPKSSNGKPLKYKLKESLATSYARKTSPAIPNNTRNR
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MSNPEEMVESSPAEVLAACLGSVEDTVDSLPLQRLNAALGWIQACHARKWEDRVSKNYEGGEDPILPPPRRRTMWPATAEAAKRSGGKEKIMHPDAPLLTRSGEGAQRSLSPASVTLAPDDEMDDARLLRACFMLIQAGRIEEALKLTDDCGQPWRAVGWIGGTPLSSDGTGNPTRALWKSNGRKIAEKMTQITHRDMMDSASRTLFPSIAYEAAIMSLLSNRVDCALANPVFQSWEDGVHAILSAERGIIEDDVLKSHNLARIEAFEGDDENGPLGSGGDLGDALQKLETATTNRVRVEGEDPFRGGMISFLVGSNALKEYIEECAFASLGAGNEDEAFFLRFITHLILYVDTALPGFSFQLALPAEVLLLLKYTDYLASRRELWSHVAVYTSLLSPENIIDVYSSFLVHVHSDQERQMTLQQARQLFPKGLDYYVLRSVVREMIMSDDDENWQREAGEDLPPAGVSPKDARMMRSVFWLCYYPEHRPDALVCANMLLRKFLHASCESDSVDGNNLHTPKVFIRILPKNLVTSAIEQCHENDDNIAAEFESIKKFLEAHNRHVQFLDVISKTAPCHKSGNKPAHSLQDNFESEIADKMERNAFRQRKVGLCKIIIESAQRVSDALMEVLTFGGGWLVDSNADDLDDRTMTVEAEARAEEMKDIRSTFAPLAVAMLYDALDTTGMWMEQALSLASIVAYDGHRLHETFNDYDMDKFLGSIAESHLKLNRCSNSRTFFEC
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNHLYFYYLLGVMNFRYDKAKESFTSSKTMTALKVVLHIVIPNSVLLVISLIGTTGILLTIPSVHVVAFAMRVIWTLLTMNITILLNYYFTGTKQRALLTECVACLREAKSESTVESAQNSPFRGSRVVLGVFLLHYINYELNQYTYVLLYDEKWPELMFYIIFYYLEMVTVMNALYFSTVLDIVHRTGQLDSDRLSRCLQRNATSEPTELDDPYWWRTIEHFYHRVLTLHRRRANYCRAFQLQLVTIALNTFIASFVIFYVNLNSILMHTHDNWLEKYKRVTECLGFFPQLCALLLICRNADRVESEQRCLMRLVIQAQTKLTKSVANMQRGDAFNGRMVLFQNQMKMAPYNLFDFDLQYFFGIVAAIVTYLVVLLQFRTIEFS
The following text describes a protein:
Function:
Represses adpA expression by binding to the promoter region in the absence of A-factor, causing repression of streptomycin production and of sporulation.
Subcellular Localization:
Cytoplasm.
Domain:
Binds DNA through its N-terminal H-T-H motif and binds A-factor via its C-terminal region.
Sequence:
MAKQARAVQTWRSIVDAAASVFDDYGYERAAISEILRRAKVTKGALYFHFASKEAIAQAIMDEQTSTVEFEQEGSPLQSLVDGGQQFAFALRHNSMARAGTRLSIEGVFLGGPHPWGDWIDATARMLELGQERGEVFPQIDPMVSAKIIVASFTGIQLVSEADSGRADLRGQVAEMWRHILPSIAHPGVIAHIKPEGRVDLAAQAREKAEREEQEARIAAEAKGAGSDAATDSGSRSGGSGLRGGGSGRGPRAGGAGDEGDEEPAGAGVAAGGVVA
The following text describes a protein:
Function:
Has a partially redundant function to ECM33 in cell wall integrity. May be involved in a repair mechanism activated in response to cell wall damage.
Miscellaneous:
MISCELLANEOUS: Present with 11700 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall. Note=Identified as GPI-anchored plasma membrane protein (GPI-PMP) as well as non-covalently-linked, soluble protein of the cell wall. Secreted by regenerating protoplasts. In budded cells, concentrates at the surface of the buds.
Sequence:
MQLHSLIASTALLITSALAATSSSSSIPSSCTISSHATATAQSDLDKYSRCDTLVGNLTIGGGLKTGALANVKEINGSLTIFNATNLTSFAADSLESITDSLNLQSLTILTSASFGSLQSVDSIKLITLPAISSFTSNIKSANNIYISDTSLQSVDGFSALKKVNVFNVNNNKKLTSIKSPVETVSDSLQFSFNGNQTKITFDDLVWANNISLTDVHSVSFANLQKINSSLGFINNSISSLNFTKLNTIGQTFSIVSNDYLKNLSFSNLSTIGGALVVANNTGLQKIGGLDNLTTIGGTLEVVGNFTSLNLDSLKSVKGGADVESKSSNFSCNALKALQKKGGIKGESFVCKNGASSTSVKLSSTSKSQSSQTTAKVSKSSSKAEEKKFTSGDIKAAASASSVSSSGASSSSSKSSKGNAAIMAPIGQTTPLVGLLTAIIMSIM
The following text describes a protein:
Function:
As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, MIOS is required to prevent autoubiquitination of WDR24, the catalytic subunit of the complex. The GATOR2 complex is required for brain myelination.
Subcellular Localization:
Lysosome membrane.
Sequence:
MSGTKPDILWAPHQVDRFVVCDSELSLYHVESTVNSELKAGSLRLSEDSAATLLSINSDTPYMKCVAWYLNYDPECLLAVGQANGRVVLTSLGQDHNSKFKDLIGKEFVPKHARQCNTLAWNPLDSNWLAAGLDKHRADFSVLIWDICSKYTPDIVPMEKVRLSAGETETTLLVTKPLYELGQNDACLSLCWLPRDQKLLLAGMHRNLAIFDLRNTSQKMFVNTKAVQGVTVDPYFHDRVASFYEGQVAIWDLRKFEKPVLTLTEQPKPLTKVAWCPTRTGLLATLTRDSNIIRLYDMQHTPTPIGDETEPTIIERSVQPCDNYIASFAWHPTSQNRMIVVTPNRTMSDFTVFERISLAWSPITSLMWACGRHLYECAEEENDNSLEKDIATKMRLRALSRYGLDTEQVWRNHILAGNEDPQLKSLWYTLHFMKQYTEDMDQKSPGNKGSLVYAGIKSIVKSSLGMVESSRHSWSGLDKQTDIQNLNEERILALQLCGWIKKGTDADVGPFLNSLVQEEEWERAAAVALFNLDIRRAIQILNEGASSEKGDLNLNVVAMALSGCTDEKNSLWREMCSTLRLQLNNPYLCVMFAFLTSETGSYDGVLYENKVAVRDRVAFACKFLSDSQLNRYIEKLTNEMKEAGNLEGILLTGLTKDGVDLMESYVDRTGDVQTASYCMLQGSPLDVLKDERVQYWIENYRNLLDAWRFWHKRAEFDIHRSKLDPSSKPLAQVFVSCNFCGKSISYSCSTVPHQGRGFSQYGVSGSPTKSKVTSCPGCRKPLPRCALCLINMGTPVSSCPDNFFQPIGGSKSDEKVDLSKDKKLAQFNNWFTWCHNCRHGGHAGHMLSWFRDHAECPVSACTCKCMQLDTTGNLVPAETVQP
The following text describes a protein:
Function:
Involved in the biosynthesis of terminal alkyne-containing amino acids such as L-propargylglycine (Pra) and L-beta-ethynylserine, that are produced as antibiotics by S.cattleya. Catalyzes an oxidative C-C bond cleavage in 4-chloro-L-lysine to form 4-chloro-allyl-L-glycine (also named L-2-amino-4-chloropent-4-enoate), with release of formaldehyde and ammonia. Is also able to react with L-lysine directly to produce allylglycine in vitro.
Sequence:
MTDLNTPESTSKPVWEHFDHVEPGIRRRIAVADPEIKEYLDGMLARIASHRGVEHPFLNAYRTTALDPEQERHLFSECYYFFRYLPFYITGMAVKTRDEMILREIILNVADEVGSDPTHSTLFADFLARIGIDKEHLDGYQPLEVTRQLNDGIRHLYTETSINKALGALYADETMSSIMVSKINDGLRNQGYDDDLRHFWQLHIDVEVGHSNSVFNAIAPYVGSKAARAEFEEGVFEFLGLVERYWDGVRELVGIGK
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MEKEQLPELKYINVNDFNINEKVIGIPVQTNEVAKYMKMFKGLCYNRIKTKCVIPYNSERMILLETPLKEQTQKLIQDNHLKTVETEVPLTIKNFNVNEIMKRYINKNIQLPSSFETVGTLAHMNLKEEQMEFKYIIGEAFLIKNYPRIQTVITKTAEISNEFRTFPLEVIAGIPNTEVTVICHGVKFVLDYAQCYWNTRLETEHIRIINQMKAGEILCDAFAGVGPFAIPAALKGVKVYANDLNPTAVKYMRINAVNNKTTIECDNMDARDYLRKIVLEKHIQPNYILMNLPATAIEFLDCIPELYLQHCMIHCYGFSPLPNAEDLKKKAFELLKGEYPITIREVRDVAPKKVMYCLSIFIESTKHLTSGNNVPEAKKTLN
The following text describes a protein:
Function:
Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
Subcellular Localization:
Periplasm.
Sequence:
MLIIKRSVAIIAILFSPLSTASNLTSQLHNFFSAQLAGVSDEVRVSIRTAPNLLPPCEQPLLSMSNNSRLWGNVNVLARCGNDKRYLQVNVQATGNYVVAAMPIARGGKLEAGNVKLKRGRLDTLPPRTVLDINQLVDAISLRDLSPDQPIQLTQFRQAWRVKAGQRVNVIASGDGFSANAEGQALNNAAVAQNARVRMVSGQVVSGVVDADGNILINL
The following text describes a protein:
Function:
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MGKNKNYNKNQFKKSKTNNDTTVAQQQQTIEEKPDFKIDGSILEGGGQILRNSVALASLFNKAISIEKIRYNRDQPGLKNQHKAGIDLMSRLFKAHLTGCSVGSCKLYYQPTQKTIQDDGVIEADTKTAGSICLMIQVSLPCLIFAPHSTKMVLGGGTNCDFAPAADYIQNVFLPIATTMGFKCEMSIDKRGFYPKGGGAVTLTTQPLTQPLSPITIVNKGEVNRIVIKSYFTSPRISPLVAERMNNTAKKLIKKDFKKVDVETELIDVSKFSFGDGTFIEIRAYTDQGCIFGATGNGAIGVPAEKVAEDAANSLLKDLQDGGCMDEYLQDQLIIFMALAKGKSQIKTGPISLHTQTSIHITSLMTGAIFTITPLTNNTQSGEETNLITCEGISYFPSDLNNNNNNSNSNTTTTTTTTTISTTTIDNQNSEEK
The following text describes a protein:
Function:
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.
Sequence:
MAAPMATEMKGDKSLLDLDEESLYKHLLLQANENAGGLFGNATPDPSQSEVNVVTPEPGVCIKTKDNSGKKVFINLCKTTEMPAPADMKESELIKLLDSDELSDYRVPLSIGEPHAEIDNSGNGCTAYDVMINNEFFEKVEKSNLFKGFLMSVVFEGLEQKYNILLQRGWSQMKKRKCLGTLHQHHLRTKSKPRILDMGSTHEDSQQYSPQDNQQSSKPLITEISSDVKSSKVTEVIDTNSEKAPEPKYIIMREPIDGHPEFLVVDVELPGVKTANTLTVDLGEDRILLHAHPKAYHLDIYLPFDVDQDFSGSQFNRDTQTLTLTLPVQPQG