lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs). Also identified in a modified version of SAGA named SALSA or SLIK. The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities.
Miscellaneous:
MISCELLANEOUS: Present with 14834 (+/-203) molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The C-terminal WD40 motifs are required for its incorporation into TFIID and function in SAGA.
Sequence:
MSQKQSTNQNQNGTHQPQPVKNQRTNNAAGANSGQQPQQQSQGQSQQQGRSNGPFSASDLNRIVLEYLNKKGYHRTEAMLRAESGRTLTPQNKQSPANTKTGKFPEQSSIPPNPGKTAKPISNPTNLSSKRDAEGGIVSSGRLEGLNAPENYIRAYSMLKNWVDSSLEIYKPELSYIMYPIFIYLFLNLVAKNPVYARRFFDRFSPDFKDFHGSEINRLFSVNSIDHIKENEVASAFQSHKYRITMSKTTLNLLLYFLNENESIGGSLIISVINQHLDPNIVESVTAREKLADGIKVLSDSENGNGKQNLEMNSVPVKLGPFPKDEEFVKEIETELKIKDDQEKQLNQQTAGDNYSGANNRTLLQEYKAMNNEKFKDNTGDDDKDKIKDKIAKDEEKKESELKVDGEKKDSNLSSPARDILPLPPKTALDLKLEIQKVKESRDAIKLDNLQLALPSVCMYTFQNTNKDMSCLDFSDDCRIAAAGFQDSYIKIWSLDGSSLNNPNIALNNNDKDEDPTCKTLVGHSGTVYSTSFSPDNKYLLSGSEDKTVRLWSMDTHTALVSYKGHNHPVWDVSFSPLGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVSFHPNGCYVFTGSSDKTCRMWDVSTGDSVRLFLGHTAPVISIAVCPDGRWLSTGSEDGIINVWDIGTGKRLKQMRGHGKNAIYSLSYSKEGNVLISGGADHTVRVWDLKKATTEPSAEPDEPFIGYLGDVTASINQDIKEYGRRRTVIPTSDLVASFYTKKTPVFKVKFSRSNLALAGGAFRP
The following text describes a protein:
Function:
Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.
Subcellular Localization:
Nucleus.
Sequence:
MEARFGGNPHHYYGPVVPELKAGGKRNLEWDLNDWKWDGDLFTASQISAIPADCRSRQLFPVTSGVEAVTVVSNSSSSCSDEGKKELEKRRRVVVLDEEDEVGGLNLNLGGQVYPIPEDELERWEGKNGKKSKVGGGTSSRAVCQVDDCQADLTGAKDYHRRHKVCSLHSKAAKALVGNVMQRFCQQCSRFHSLEEFDEGKRSCRRRLAGHNRRRRKTHPETPTNGVSLNDERSCSYLLVSLLRILSNVQSNNTSGSEQSKDQDLLAHLLRNLASFAGTVNDKNTSGSQCLQDAGTSFATPEKEHPQPVSQTVNLSGSEMLHRGSVQTPAPSEITFPSNNKTPNEGGKTKLNNIDLNMVYDGSQDCSFENPENTDNLPLWLRHQPNKSSPPHTSGNSASTATQSPSSSSGEAQSRTDRIVFKLFGKDPSELPLALRNQILDWLVHSPTDIEGYIRPGCIILAVYLRMENSSWDELCYDLSSHMRKLLDASSNSFWRTGWIYTRVLDHVAFSCDGQVILNTSLPHYKGHRNSSILNISPIAVSVSETARFSIKGINIPWSTSRMMCVLEGSYLVQTNCSELMEATDSYIKHEDIRSFNFSCSIPNISGRGFIEIEDDSLSSNFFPFIVAEQDVCSEICMLENDLAITSDHTEKEKKEVEARTRALEFVNEMGWLLHRSQLKVRLTCMDPNSDLFSFKRFKWLIEFSVDHDWRAVVKKLLAIIFSGTVDSADYASVEVALVETGLLHRAVRRNSSSMVELLLNYGQENGTTPGLFRPDAVGPGGLTPLHIASGKDGSESVLDALTNDPQLVGLDAWRNSRDSSGLTPYDYASLRGHYNYIHLVQRKINRKKGHVVVDMPPPHKVSGFETEKAVVVRPVVVQKSCNQCERKLAYYGGGRSSLAIYKPAMLSMVAIAAVCVCVALLFKSSPQVMYVFQPFIWERLKYGAS
The following text describes a protein:
Function:
Histone methyltransferase.
Subcellular Localization:
Nucleus.
Sequence:
MILKRTLTFEEQNLKRCKVGSEIEYGGKKGEIIVYRRRNRASVDQPPCREEAEDCTTSSAGSLTSKESQDQSKSLRGRVRVAPSRFNDSVVDAWGNRRRKVESKESGRDDEVRVVKKVKGGHGKSAENGSSRKDNGDSSEVDFDGKDANLRVSMLSSSDDANSLSVRGKGESFAESGMPKDPAAMRKGVYRPEDFAVGDLVWAKCGKRFPAWPGKVIDPDSQAPDSVLKHCVPGSLCVMFFGYSKNGTQRDYGWIRQGMMFPFTEFMEKFQDQTNFYNNKASDFKKALEEAVLAENGVEGSCGAAEISCPESSATESDQEHGTASRSQARFPDTYSLFSLDLQFFSVGSCHVDVRTCDGCGTVMQKSQPEELLCKHCSKVRRKFSYSSVFFGQKELNPNLLLQLWKSNQYCGICKRSWHSSDGEDWELEHSNYHCPGCRAQHECAPTVLNEQSPTVLNEQNSVFESTEKATETELADEVTVVCNGMEGTYIRKFHVIECKCGSCGARKQSPSEWERHTGCRAKKWKYSVKVKDTTLTLEKWIAGCSALPLEQGTADCRVLDKQMMLSLLEVAVHQECYGVSKAQDLTSWVCRACETPDIERECCLCPVKGGALKPSDVEGLWVHVTCAWFRPEVGFLNHEHMEPAVGLFKIPVNSFLKFCRICKQTHGSCVQCCKCATHFHVMCASRAGYSMEMHCVEKDGVQRTRKSIYCAFHRKPDPNSNVVVHTPSGVFGSRNLLQNQNGRIKGSRLVLTKKMKLPDSDIHPQTEKSHGSLSAARCRIYSRSNTKACIWGSHLIFGHLTFFSIFSCLTTSMKFGTNVSLLLLLFQKVDLEAIPHRLKGPSHHSLGAIENLNSFKASLSFRAPFVFIEADTSGFTSFKERLKHLQRTENLRVCFGKSGIHGWGLFARRSIQEGEMIIEYRGVKVRRSVADLREANYRAQGKDCYLFKISEEIVIDATNSGNIARLINHSCMPNCYARIVSIGDGEENRIVLIAKTNVTPGEELTYDYLFEVDESEEIKVPCLCRAPNCRKFMN
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MVGGGVIRQLLRRKLHSQSVATPVLSWLSSKKANEDAGSAGLRAFALMGAGITGLLSFSTVASADEAEHGLECPNYPWPHEGILSSYDHASIRRGHQVYQQVCASCHSMSLISYRDLVGVAYTEEEAKAMAAEIEVVDGPNDEGEMFTRPGKLSDRLPEPYSNESAARFANGGAYPPDLSLVTKARHNGQNYVFALLTGYRDPPAGISIREGLHYNPYFPGGAIAMPKMLNDEAVEYEDGTPATEAQMGKDVVSFLSWAAEPEMEERKLMGFKWIFLLSLALLQAAYYRRLKWSVLKSRKLVLDVVN
The following text describes a protein:
Function:
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSEIKKTEKLGVKSSKHLAAGALGGFISSTTLQPLDLLKTRCQQSQRDSLPKMVRRIILHEGGVFSLWKGTLPSILRSTTGSSCYFYFLNWLRHFAPQSKNIASSHIQNLWMGGFARAAVGFAFMPVTVIKVRYESNLYSYTTIYSSIRDIWKKEGISGFFRGFGVTALRDAPHAGLYVYFYELSKQNLHKLFDRFSPSSSVQGTVPHRNIVNVMSGLISGATATAITNPFDMLKTRVQLEPHIYKNFLHSAKLVYANEGFRGFLDGFFLRVLRKSISSTITWSVYEWALHRKVIK
The following text describes a protein:
Function:
Required for checkpoint signaling in response to DNA replication stress; either resulting from normal embryogenesis or induced by the DNA synthesis inhibitor hydroxyurea (HU). It is not required for the G2 arrest resulting from DNA double strand breaks induced by ionizing irradiation (IR). Necessary for the timely phosphorylation of Cdk1 at the mid-blastula transition. May have a minor role in maintaining genomic stability in mitotic cells.
Subcellular Localization:
Nucleus.
Sequence:
MSESLAETAAAAENEEQADDSMEKLVFDEEDEQMVSGEDLLGGKSLIMSDDSEAEDGSQEKPLSPKDRRRRMMDSDQEEDAMDQGNGDSIKNSEDVEEEMVSRPKKKVSAIIDSDNDDEQQAEKKTQKEEGKQPVKSKKKRSQVNQEDQEKPVKSNKTKKAVKNKTQANKAEDDQDNPSKEDKPKKVVKNKKQTNKDGKPQTNEEYDHHQQHEKPAKTQKSKKLAKKQKQQEDDKEDNGTEQEKKKPSPKSKAKKSDKSKIDSLMDNEEDAGEDLKMYQEDQEPQKQKTKKSAKKTNKDSKEESGEDQEHQEQKKPLKKIKLDNIDTKEDKEQIVKPKKMAKKNKQKVLSDDESEENQNEKVDQDHDLKKMSSENELEMGSDKEDQEMQEPPKKAKKNKQRMDSESEDEIPKTESEKITSSPKNKLKGLVDSESEPEETAEEVSPVKNKLKGLVDSESEPELDNPEESAGEQEAPMESALSREKPKKAKVVRESAKKALEGMQAIQSEQQRLHREAHINVPYHQPKPRTLKEFLSRRTINAPLATALAGGSPMPSRQPRKSVGLRMTREELEAYAKLMEDRAKEATEFFKSESESDEEDDSENEEPMELKDNPGVMDEMLDNPKTPEQPKNDTEDMTSQAVIEVPVLGEDKTDDTVGDEAMVADSITEEEPIASTSTAAALKLADNFEIQQETNAKSPSKVCLVTEVVELPKLDLSTINITPSSKPATPKISEVIRQLKIEKSLDESPSLKGDPNMVIDLETGDMFAKKPTGVDDLLNRLMKTREAKKHKTTETVNILTTEHGKLEMSKVSIHLHEEEIAKEPKPGAGYMKMQEHLKTLITKKRMEDLRKKQAEEQEKMAEDEEEGMDVDEEYEPEDKPGYAEVTINEDEEIIDKVDSTAEDDGDAEENKNDADEDPEDNPVEDSEDEKNDSESEQECEANPEPETQTRKKNRIIKAFEDDNSDEDDLDLLQTPKPSNVAPITATQLQLSAHKLFDVETRRTASDEENELLDLCSGQFPQTQMLSSDAPSVDTAVISQIPMTQFGGSSQAADELEGLCSGTFATQLPSQAPTQQPEQQEESEVPAAVANRIVSSDEEAQEDALEVDKPRNKKLTKKRPKKKAKLGFSDDEDSDDEVEEFDEESDAEPVEEIPETFVDYDSEENEIVVEMTKKDRKIRAANFVDKEAELSESEWGSADEDEKNMDEYDIELGDEDQFDRDKLRHELGQIHARKMMDQDIREVRKIKELLFEEEEEGANRQRQFRWKNVEAGFSLDDNRTDNGEGNDGSGDEENEHLWRKIRYEREQLLLEKGLKPEVASPLSTSVINTSNNGNSPAIRRLNIISSKKTTVEVKKNSPFLISKTIAGKQQKSAVRGSFLIRDQQTLSKLAGLTKGTSGDVDAAEGTISVKSAKAKNFVFATLTEEEHENRKRKAADILNSSTETGVNFIKKPKLEPRRDKCLIDQLL
The following text describes a protein:
Function:
Required for the deacetylation of acetylated sterols. Involved in the resistance to eugenol and pregnenolone toxicity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MAANSGLDSKVEYYRLQENEIISAVSSEDADQNDAGFRLSTIHLHLFHGLKFAALLFTVVPVFIILDSMKIIFQRKRRFCLDHVNRSFLRQSSWILDERICQYVLNPLFVCLYPSTFSSPTYVKCNIPIEDQKSPENNIFQDHQLNAPKIVSTKFYQYVMPEGFDPTTDPVLVFYHGGGYALKLTPTSFSFLNNMRNAFPKMAILVPDYTVTATDDQSKKYPLQILQNVAIFDYVVKTMGCKNVVIMGDSAGGNAVLNIVLYLRKCHREIYPKKVIAISPWANATFFHEGEKEYMQGTQEWDGLCLKSHSMFGRMFVGNNPNVDFTSDPFVNIEKNFETKMWQDILKKCSVMITYGSDELLSFQNKILAKKMSDASEGCNHFTAKNVLVEHQGYHTGPILNYSRNMDRWTNIPSIARILEFMQS
The following text describes a protein:
Function:
Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. MlaB plays critical roles in both the assembly and activity of the complex. May act by modulating MlaF structure and stability.
Subcellular Localization:
Cytoplasm.
Sequence:
MSESLSWMQTGDTLALSGELDQDVLLPLWEMREEAVKGITCIDLSRVSRVDTGGLALLLHLIDLAKKQGNNVTLQGVNDKVYTLAKLYNLPADVLPR
The following text describes a protein:
Function:
Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Transactivates the PRF1 promoter in natural killer (NK) cells and CD8+ T cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Is a transcriptional regulator of inflammation, controlling T-helper 17 (Th17) cells and macrophage inflammatory responses. Required for sustained transcription of anti-inflammatory genes, including IL1RN. Is a negative regulator of pro-inflammatory cytokines expression including IL17A, IL1B, IL6, TNFA and CXCL1. Down-regulates expression of TREM1, a cell surface receptor involved in the amplification of inflammatory responses (By similarity).
Subcellular Localization:
Nucleus, PML body. Note=Accumulation into PML nuclear bodies is mediated by PML.
Sequence:
MAITLQPSDLIFEFASNGMDDDIHQLEDPSVFPAVIVEQVPYPDLLHLYSGLELDDVHNGIITDGTLCMTQDQILEGSFLLTDDNEATSHTMSTAEVLLNMESPSDILDEKQIFSTSEMLPDSDPAPAVTLPNYLFPASEPDALNRAGDTSDQEGHSLEEKASREESAKKTGKSKKRIRKTKGNRSTSPVTDPSIPIRKKSKDGKGSTIYLWEFLLALLQDRNTCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLVVIEDEDESSEATAAPPQASTASVASASTTRRTSSRVSSRSAPQGKGSSSWEKPKIQHVGLQPSASLELGPSLDEEIPTTSTMLVSPAEGQVKLTKAVSASSVPSNIHLGVAPVGSGSALTLQTIPLTTVLTNGPPASTTAPTQLVLQSVPAASTFKDTFTLQASFPLNASFQDSQVAAPGAPLILSGLPQLLAGANRPTNPAPPTVTGAGPAGPSSQPPGTVIAAFIRTSGTTAAPRVKEGPLRSSSYVQGMVTGAPMEGLLVPEETLRELLRDQAHLQPLPTQVVSRGSHNPSLLGNQTLSPPSRPTVGLTPVAELELSSGSGSLLMAEPSVTTSGSLLTRSPTPAPFSPFNPTSLIKMEPHDI
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which ubiquitinates histone H3 at 'Lys-14'. Required for male fertility, via inhibition of SPOP-mediated BRDT degradation when in the presence of acetylated histone H4 in early condensing spermatids. Stabilization of BRDT allows it to facilitate histone removal in early condensing spermatids and promote the progression of histone-to-protamine exchange. Promotes the expression of steroidogenesis proteins in the testes, and as a result plays a role in maintaining testosterone levels and repressing osteoclastogenesis. Promotes transcription of cardiac enhancer genes by facilitating binding of cardiac transcription factors such as MEF2C and GATA4 to target gene promoters. Ubiquitinates histone H4. Ubiquitinates histone H2A and H3 as part of the nucleosome core particle.
Subcellular Localization:
Nucleus.
Sequence:
MKTIKEKKKERQRLRKSAKTRRVTQKKPSSRPVCRLCLREPGDPEKLGEFLQKDNLSVHYFCLILSSKLPQRGQSNRGFHGFLPEDIKKEAARASRKICFVCKKKGAAINCQKDQCVRNFHLPCGQERGCLSQFFGEYKSFCGKHRPTQDIQRGKAGEESCVLCCEDLSQASVENIQSPCCSQTIYHRKCIQKYAHTSAKHFFKCPQCNNREEFPQEMLRMGIHIPDRDAAWELEPGAFSELYQRYQHCDAPICLYEQGRDSFEEEGRWRLILCATCGSHGTHRDCSSLRSNSKKWECEECAPSAEATDYTPENSGDIPCCSSTFHSGRHFCRDTSLEENPGPSWTNWPGPSLLEKPESSGGRRSHSWRSKGVKITKSCKKSK
The following text describes a protein:
Function:
Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
Sequence:
MHIKTLPVVAAVGHILCHNIADDQGRKAFNKGRRLRPEDISQLTGLGVATVRVAVLEPDDVHEDEAALRLAQIVAGPGVIIGEPHAGRVNLRSAYAGPLMIDTEALLAINLIDGLTVATLPPYTLVAADQMLATIKIIPFAVPASDLAQAGAAADAQSVLRVAPMVRRRIGVALVSSPAARARVERGMLPAIVGRITDLGATMIGCCHVPPDEAEVAASLHELLAAGADLIITAGETSVVDRDDVIPRAVRRIGGEIAHYGAPVEPGNLLLLAYLNAADDRIPLIGAPGCVRSRDQNIVDLILPRLMANERIGRREIVALGPGGLLGAARRG
The following text describes a protein:
Function:
Regulator of cell surface receptor signal transduction. Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity). Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAREDSVKCLRCLLYALNLLFWLMSISVLAVSAWMRDYLNNVLTLTAETRVEEAVILTYFPVVHPVMIAVCCFLIIVGMLGYCGTVKRNLLLLAWYFGTLLVIFCVELACGVWTYEQEVMVPVQWSDMVTLKARMTNYGLPRYRWLTHAWNYFQREFKCCGVVYFTDWLEMTEMDWPPDSCCVREFPGCSKQAHQEDLSDLYQEGCGKKMYSFLRGTKQLQVLRFLGISIGVTQILAMILTITLLWALYYDRREPGTDQMLSLKNDTSQHLSCHSVELLKPSLSRIFEHTSMANSFNTHFEMEEL
The following text describes a protein:
Function:
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.
Subcellular Localization:
Cytoplasm.
Sequence:
MQDLKRKNRKRLTTTTILKPGLPPKFFLNLLKEISPIVAIDNTQTILFANQSFQKEFAGSSRSLIGKNLFRILNLNPVDHEEMESNINLSKWGKIQNQEFRKQKIYYGYSVFRFGDHIGIILKNITENKRLERKIASLHTQLLQSQEEERIRLSGELHDGVGQTILAAKLNFQAYNRNPKVYGAQFDTGLLLIDKASQELRDIYTNLHPSTLREIGLEAAIRSLSSDLFPPMDIEADLDLNLKLNLEQTTANQVFRIVQEIFQNVIKHSQASKISLKIQAKGRQLFIDAKDNGIGFQERKVRARSSGFGLENIRRRVEDLNGKIKIDSSAGKGTKFIIRIPLEKNKNTYAKKT
The following text describes a protein:
Function:
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. Represses expression of MEOX2.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM
The following text describes a protein:
Function:
Probable transcription factor which regulates early embryonic myogenesis, in cooperation with transcription factors unc-120 and hlh-1. Involved in controlling the number and position of somatic gonadal precursor cells (SGPs) in the gonadal primordium, and embryonic body shape.
Subcellular Localization:
Nucleus.
Sequence:
MVKSTTAGNNAVSSLESTDSKKSRKEKSREKEHRRAQCINSAFEILQQHIPYLKSEERKSLPKIKTLRLAMQYIDHLKKLLGGNEMLETDCNESRPLTHSDFRVNISNEIRIRNSYRERAHNQELDEATVKRILAREDQRRRCSSVPEGIQRYTPYQSRQFGPISNNVCNFRHVDANQYNTNFMEYQTQMVQVANFPNQFSHEYYNYGTFPVIDPTSLENSNPILQ
The following text describes a protein:
Function:
Probable transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTTIVEEEPLFYIVMLSIGSFFALGSIIIAVILILQHFIHYNKPNHQKYIVRIIMIAPIYAIHSLLSLFFKRQFWALFFDISRDCYEAYVLYCFFKLLICFLGGEEALKELLSKKDTQPLTWPLGYFFSFTPKKSFYRLSLGLVLQYAIIKPTLAIVAAILYYNNKYLEGDFSISQGYLWITVINNISVLIALYFLVMFYEVFQNELSPHSPILKFLVIKSVVFFLFWQTVVITVLIWFDALPKSDVYSSEHIGYFINDFLVCIEMFITSIAMGICFSYSDYVIDKSTHDEILGNGKRSSSRGIGSRSGRNIKISSKIKNIKNNFNRYRHNIGDGLSDVNNPKDIILDTIMVAKLNKNNNNTNNNEINNGIIDNNNSNNIENNGKSRNNIENNIDSQDYFNFIDLNTNDKEKQSKSKYFKIKMPDSDQSSLINLDQCESPSILYGSLNGASNNNNNNNNNNNNINNNNNNNSNNSNNNSNSQFESIDINSNSVNSNKNQSDAILFTF
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Sequence:
MAEGAAMDGAAGREGRPAEEHEETHKGYQPIGEIRACGGLDKLVGPTAGARPASLARMHLDPALDKQLSAAVGVALGTWYNLEAMAVFCLKDTVALPGFTRYFRGRAGQEYREARSIMDYVSQRGGAVQFKEIAPPPNSFNHEEKGDALFLMEYALALEKVQNDKYVQLFRAAGGSGDPGVQAFVQVRLLGPRAAIIQRTAQCVAQLRRLGKGAGVFVFNAQLLAEQPREESLGNEAEDQDWSLPGSGACKRAKSGVAQG
The following text describes a protein:
Function:
Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin.
Subcellular Localization:
Nucleus. Note=Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis.
Sequence:
MAREKEMQEFTRSFFRGRPDLSTLTHSIVRRRYLAHSGRSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGEDHPAVMRLKRYIRACGAHRNYKKLLGSCCSHKERLSILRAELEALGMKGTPSLGKCRALKEQREEAAEVASLDVANIISGSGRPRRRTAWNPLGEAAPPGELYRRTLDSDEERPRPAPPDWSHMRGIISSDGESN
The following text describes a protein:
Function:
DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEAVECPEHGVACLLKTGVRDGPNKGKSFYVCPADACRFVLAAAIPVSHCLLHEDCVVGLQGLLLPPGKEEYRLFFQCIRSKAAGKQWCGSIPWQEPHSKERSVTKSQRASELLHYSSTQQRNPFKVLDKNQEPSLWKQFTKGEGEEKMVDKKQKEKGDVLLDQKEERKPEPNCCMKKNLSSGLEVKKKQPAPQEQQRGEKTELQHEAKENKGMHKRNLSEVKSKQCHVEELRKPSGSLQVKSNIESHHVEKKSEPLREKEAKPLPRIIHSQNPVSKPQKGEHVSKEHSKSWEAREIKASDDPSSQTNQQSEPWDGPAPGGPAAQCAPPAKECSLGQRLEVASSHVFTSSKPPLFFGSTLNSQKEESLPLPGQDMQRKTPPATGGSRKVEPSDQAAQRVYLTAQLRQKKSTLKSVNIQALPDKGQKLLKQIQELEEALGALALSPEPDTNEKSNTQVLQQKNITKATTDPPHLVPPKPLQGEDLQPLVSQGLKAACPVAAGGSSWCSGGPMQQDGPHATWKIISKAIDELHESLESRPGETAVAEDPAGLKVPLLLHQKQALAWLLWRESQKPHGGILADDMGLGKTLTMIALILTQKNREKTKEEDKNVALTWLSKDDSREFTSRGTLIICPASLIHHWKNEVMKRVSSNTLRVCLYHGPNRDQRAKVLSTYDIVITTYNLLAKEIPTQKEEGAIPGANPSMGKDIAKTPLLRIVWARIILDEAHCVRNPRVQTSMAVCKLQAHARWAVTGTPIQNTLLDMYSLLKFLRCSPFDDFQLWKSQVDNGSKKGGERLSILTKSLLLRRTKDQLDSTGKPLVMLPQRQFHVHRLKLSEDEENVYSVLLAKSRSALQSYLKAGREGGGNLSGRSPGNPFSKVAQEFGSSRPGPCVAADSQRPGTPHLLLTRLLRLRQCCCHLSLLKSALDPAELKSEGLALSLEEQLSAMTLSEVCDMEPSPIISLNGERFKAELFDNTRASSKISSLLVELEAIRGNSGSQKSVIVSQWTSMLQIVAWHLKKRGLTYATINGSVRPKQRMDLVEAFNSSRSPQVMLISLSAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQQKDVVVHKFICEGTVEEKILHLQEKKKTLAKQVLSGSGTSVKKLTLADLKVLFGI
The following text describes a protein:
Function:
Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE associated with ER-derived vesicles (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MNPRREPRGGRSSLFDGIEEGGIRAASSYSHEINEHENERALEGLQDRVILLKRLSGDINEEVDTHNRMLDRMGNDMDSSRGFLSGTMDRFKTVFETKSSRRMLTLVASFVGLFLVIYYLTR
The following text describes a protein:
Function:
Meiosis-specific cyclin. Required for normal homolog synapsis and recombination in early to mid-prophase 1. May regulate the timing of sister chromatid separation.
Sequence:
MKEIAMRNSKRKPEPTPFAGKKLRSTRLRRKRAQISPVLVQSPLWSKQIGVSAASVDSCSDLLADDNVSCGSSRVEKSSNPKKTLIEEVEVSKPGYNVKETIGDSKFRRITRSYSKLHKEKEGDEIEVSESSCVDSNSGAGLRRLNVKGNKINDNDEISFSRSDVTFAGHVSNSRSLNFESENKESDVVSVISGVEYCSKFGSVTGGADNEEIEISKPSSFVEADSSLGSAKELKPELEIVGCVSDLACSEKFSEEVSDSLDDESSEQRSEIYSQYSDFDYSDYTPSIFFDSGSEFSEKSSSDSPISHSRSLYLQFKEQFCRSTIPNDFGSSCEEEIHSELLRFDDEEVEESYLRLRERERSHAYMRDCAKAYCSRMDNTGLIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKSERTLILVGIASLTLATRIEENQPYNSIRKRNFTIQNLRYSRHEVVAMEWLVQEVLNFKCFTPTIFNFLWFYLKAARANPEVERKAKSLAVTSLSDQTQLCFWPSTVAAALVVLACIEHNKISAYQRVIKVHVRTTDNELPECVKSLDWLLGQ
The following text describes a protein:
Function:
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity).
Sequence:
MRVKGTNTTRIRRKKWLKQASGSFGTRKASFKAAKQTVIQASKYAYRDRRQKKREFRSLWILRLNAALRAQGMTYSVFINELKKAKIVINRKVLSELAIKEPNKLNLIINTIKKPTNKPTVAKT
The following text describes a protein:
Function:
Demethylates proteins that have been reversibly carboxymethylated.
Sequence:
MEASALKKVRCKLIAPLGLPPPSSKSFSRPSGMGKKKDYTPIHWSRYFTSREKIVVNEDGDSFQVYRRGSSGPLLVLLHGGGFSALSWSLFAECIEGLVSCQILAIDMRGHGDSKTHNDDNLSAETQADDIVSVVKHVFGSDPPPIVLIGHSMGGAIAVHAAATDQLPMIAGLIVIDVVEGTAMEALASMQNFLRSRPKQFLSLEQAIEWSVRSGQIRNGESARVSMPGQLRSDVTGECATSDVPETVTTPTASSPLDATTQTSNALKHGECITEEDEDEKIESSPSTREPTFFPPAVSPKTGYHWRIDLTKTEHQWPGWFHGLSATFLAIPVAKLLLLAGIDRLDRELTVGQMQGKFQMQVLPQCGHAVHEDVPDKVAEVVATFLVRNRLTSPKEKFNWVMPAC