lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for the assembly of mitochondrial cytochrome c oxidase.
Subcellular Localization:
Cytoplasm. Mitochondrion intermembrane space.
Sequence:
MATGAPGGNFRTWTPTPPERGSFPLDHDGECKEYMTKYLTCMKFTENKNAPNCRILAKQYLKCRMDNQLMEKSDWDSLGLVNLPGENDVELDHHHHLNNNNTKADGKSGSSNSNQNLANTTNNNTGTSSGTK
The following text describes a protein:
Function:
Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs) (By similarity). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (By similarity). Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning. Plays a role in the maintenance of lens transparency. May play a role in muscle cell strength. Acts as a molecular adapter that functions in neurite outgrowth by activating the RAC1-ARF6 axis upon insulin treatment (By similarity).
Subcellular Localization:
Cell membrane. Cytoplasm. Nucleus. Cell projection, growth cone. Nucleus speckle. Note=Colocalizes with TSHZ3 in the nucleus and in axonal growth cone. Colocalizes with TSHZ3 in axonal growth cone (By similarity). Colocalizes with TSHZ3 in the nucleus (By similarity). In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP (By similarity). Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus (By similarity). Nuclear translocation is under the regulation of APP (By similarity). Colocalizes with NEK6 at the nuclear speckles (By similarity). Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity).
Sequence:
MSVPSSLSQSAINANSHGGPALSFPLPLHAAHNQLLNAKLQATAVVPKDLRSAMGEGSVPEPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEAETAPLGPKGLMHLYSELELSAHNAANRGLHGSALIINTQEQGPDEGEEKAAGEAEEDDEDEEEEEEEEDLSSPPGLPEPLENVEVPSGPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHQEGFEEGEFWKDEPSEEAPMELGLKDPEEATLSFPAQSLSPEPVPQEEEKLSQRNANPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMAGGWGEGKDLLLQLEDETLKLVEPQNQTLLHAQPIVSIRVWGVGRDSGSNRDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMSERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQTSTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGSQTP
The following text describes a protein:
Function:
Siroheme synthase involved in methionine biosynthesis.
Sequence:
MASSNLPTAPSAYHTTLLTAQDCREHVHLIIGSNPLAASRVAQSLSVGAKPILIAPVESDMTPTAADSQQNQKRELHHNLANYISSGALTHLDRPFADEDLTTLGRSEVDNVVDAVFVTQHDQLLAERISALCKRKRIPVNVLDNPALCSFSLLSVHVDGPLQIGVTTNGRGCKLASRIRREVASALPKGLGAACARLGDVRRRIITEDAEARTAAGSAIAAAVNEGVDDSIDQSATFNKLVTELDVQAEAAKTRRMRWLAQVCEYWPLKKLVEITDDDVESILQAYPGFSSDNSSASPQPVLPGAVSEGGSSSTTTTSSSSNGRIGRIFLAGSGPGHPDLLTRATYKAIQSADLILADKLVPSGVLDMIPRRTPVSIARKFPGNADRAQEELLEQALEGVRAGKTVLRLKQGDPFIYGRGGEEVAFFREHGLGDRVVVLPGITSSLSAPLFAGIPATQRDVSDQVLICTGTGKKGKPPAPPEYVGSRTVVFLMALHRIGGLVKELTTRLGEADGVAEVQEGEKQRALWPLDTPCAVIERATCPDQRVMRTTLRYVEQAIEQEGSRPPGLLVVGRACEALYTPKQEGQPWVVEDGQFKDLDFEDSLGLSLDATSGVAHTGAA
The following text describes a protein:
Function:
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration (By similarity). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane. Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes. Simultaneously, by compromising mitochondrial membrane integrity, promotes the release in circulation of potent damage-associated molecular pattern molecules that activate the innate immune response (By similarity). Plays a stem cell regulator role in the intestinal crypt. Within intracellular compartment mediates Paneth cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ICS). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ICS cells and tissue regeneration (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner (By similarity).
Subcellular Localization:
Secreted. Cell membrane; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein.
Sequence:
HLLDFRKMIRYTTGKEATTSYGAYGCHCGVGGRGAPKXAKFLSYKFSMKKAAAACFKYQFYPNNRCXG
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Responsive of the major PPIase activity in the chloroplast thylakoid lumen. Regulates the accumulation of Rieske protein, an essential component of the photosynthetic electron transport chain.
Miscellaneous:
MISCELLANEOUS: The interaction between FKBP and the Rieske protein probably occurs before they are imported into the thylakoid.
Subcellular Localization:
Plastid, chloroplast thylakoid lumen.
Sequence:
MSSLGFSVGTCSPPSEKRKCRFLVNNSLNKAEAINLRNKQKVSSDPELSFAQLSSCGRREAIIGFGFSIGLLDNVSALAETTSCEFSVSPSGLAFCDKVVGYGPEAVKGQLIKAHYVGKLENGKVFDSSYNRGKPLTFRIGVGEVIKGWDQGILGSDGIPPMLTGGKRTLRIPPELAYGDRGAGCKGGSCLIPPASVLLFDIEYIGKA
The following text describes a protein:
Function:
Required for 60S ribosomal subunit biogenesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MLVLFETSAGFALFKVLDEGKLSKVEDLSKDFSNAESARQIVKLKAFSKFENMSEALEATTLLIDSKPSKGLRKFLRANCDGETLGVADSKLGNIIKEKLQIDCVHNNSVMELIRGLRNQLNELIAGLAVQDLAPMSLGLSHSLSRYKLKFSADKVDTMIIQAIGLLDDLDKELNTYAMRVREWYGWHFPELAKIIQDNIQYAKTVKLMGNRENAAKLDFSEILPEEVEIELKEASMISMGTEVSELDLINIKELCDQVLSLSEYRAQLYDYLKSRMNTIAPNLTALVGELVGARLIAHGGSLLNLAKQPGSTVQILGAEKALFRALKTKHATPKYGLIYHASLIGQAAPKLKGKISRSLAAKTALAIRCDALGDGQDNTMGLENRAKLEARLRSLEGKELGHVAGSAKGKPRIEAYDKDRKKSIGGLITAAKTYNPAADSLLGKLEKAIEEEAEAPVTGQEKKEKKKKKKRVEEEEDSKPEVENVGKDEKKKKKKRTEEVEEVQNGSEEKEKKKKKKRKHDEDEEEAEQPSKKKEKKKKKSQE
The following text describes a protein:
Function:
Not required for methylation of histone H3 'Lys-4'.
Sequence:
MNPERQETISPKNVPFQPVPTPNQQSLQSRMLESNQAVPDAFQKVAAWNHYNAVATPPIGVPQTARPPSNQSPHPNPPGYPYQSHQQQFHPLAIAFQQPFGLPQQVIYPPPPPGFTPHRVQVSPVGLLGPPGFFPQFAGSTTSQGNPSEVSVRTKSAEGTTGPIAPSITTKPTSTIQVAPPRDPVAPTTSSSGITKKPENGEFSLVKTISGHTKSVSVIKFSYCGKYLGTGSADKQIKVWNTVDMTYLQTLASHQLGINDFSWSSNSQFIASASDDTTVKIFDVISGACLRTMRGHTNYVFCCSFNPQSSLIASAGFDETVRVWDFKTGLCVKCIPAHSDPITSISYNHDGNTMATSSYDGCIRVWDAASGSCLKTLVDTDHAPVTFVCFSPNGKYLLSAQLDSSLKLWDPKKAKPLKYYNGHKNKKYCLFANMSVPLGKHIISGSEDGRILVWSIQTKQIVQILEGHTTPVLATDSHPTLNIIASGGLEPDNVIRIWRRN
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center.
Sequence:
MAFARKPGTAQTLAQKLYNIHSKSLPFAAPESELEICESKLVQCLLRMMQGYSSLLFYWEDRDKMFCIKNAIHVNHLSKSSLNSILHQFIYGATCLRLVELFVKQVENSSARFPPTLKAFTNSVSAKLKRLRGIALKVEKESAGSSNETTLTLLGLVKTLSSVCSGAEYLLQVVHGAIPHNYFECTVPAGEVAVHILDHLYKKLNEVCLVQGGEEEAYHTLLALFVGSLQPLIEGLDSWLYEGTLDDPFEELFFYANNSIGVDDATFWEKSYLMRPLRQRKLNCAPIFEGKSRASNKRGISDAESNVLSMREKDGENYEIVFCPLFIQRIAKAIVSAGKSLQLIRHIYGQSKNSMAGPSLVKIDPLDGPTAIQEEISQGDTFLRESDSRYGGRSYAWKMGRLTLFEMFSVSLVGLIGDDCHIYKGISHQYPWSFQIDQLCELFMNKTELEGENGDSQRKNWESLIVDIMWQKDPHVHIKMERLSSQCEVEDINGNIEDPLQIHSFWPANPAITACRNLLDRSKESWDKLNVSRSFYLPPLNDWCLREAIFGDSGLETNNVDEFTEGTECIKDKERISEALFSQLKGTNYILGFGIGKSEHHHEQNDTRTLESLFPFPTLLPCLTDYPNISQLLPYQKNSTLATRVLNWIESIELKVDFVGKHILLKLMDGWRLMDELGLLRAIYLFGSGDLLQQLLTVLFDKLDRGEYWDDDFELNTLLQESIRNSADGMLLSIPDSLVVTISKHPARDGEHALSPVSTPKSSRNHSFGIGALDPLQFTYKVSWPLELIANQEAIKKYNQVMNFLMKVKRAKFVLDKARRWTWKDRGATNINQKRHLLLEQKLLHFVDAFHQYVMDRVLHSAWLELCEGMASAGSLDEVIEVHESYILSVQRQCFVAPDKLWAMIASRIRSILGLALDFHSIQHTLCSGGAAPAIKARCELEVDRVERQFDECIAFLLRVLSFKLNVGHFPHLVDLVTRINYNYFYMSDTGNLLTMPTSDVSTSKPGQPNRKNPPSHN
The following text describes a protein:
Function:
Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis.
Miscellaneous:
MISCELLANEOUS: Present with 1550 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Domain:
The PABA component provides the glutamine amidotransferase activity; The PABB component catalyzes the formation of ADC by binding chorismate and ammonia.
Sequence:
MLSDTIDTKQQQQQLHVLFIDSYDSFTYNVVRLIEQQTDISPGVNAVHVTTVHSDTFQSMDQLLPLLPLFDAIVVGPGPGNPNNGAQDMGIISELFENANGKLDEVPILGICLGFQAMCLAQGADVSELNTIKHGQVYEMHLNDAARACGLFSGYPDTFKSTRYHSLHVNAEGIDTLLPLCTTEDENGILLMSAQTKNKPWFGVQYHPESCCSELGGLLVSNFLKLSFINNVKTGRWEKKKLNGEFSDILSRLDRTIDRDPIYKVKEKYPKGEDTTYVKQFEVSEDPKLTFEICNIIREEKFVMSSSVISENTGEWSIIALPNSASQVFTHYGAMKKTTVHYWQDSEISYTLLKKCLDGQDSDLPGSLEVIHEDKSQFWITLGKFMENKIIDNHREIPFIGGLVGILGYEIGQYIACGRCNDDENSLVPDAKLVFINNSIVINHKQGKLYCISLDNTFPVALEQSLRDSFVRKKNIKQSLSWPKYLPEEIDFIITMPDKLDYAKAFKKCQDYMHKGDSYEMCLTTQTKVVPSAVIEPWRIFQTLVQRNPAPFSSFFEFKDIIPRQDETPPVLCFLSTSPERFLKWDADTCELRPIKGTVKKGPQMNLAKATRILKTPKEFGENLMILDLIRNDLYELVPDVRVEEFMSVQEYATVYQLVSVVKAHGLTSASKKTRYSGIDVLKHSLPPGSMTGAPKKITVQLLQDKIESKLNKHVNGGARGVYSGVTGYWSVNSNGDWSVNIRCMYSYNGGTSWQLGAGGAITVLSTLDGELEEMYNKLESNLQIFM
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MIDFQAVVMAAGRGSRLTELLTPDCPKYLLPIGNLPMIYYPLCALKKAGFTEVIVIAPSSGKQKIDETLAEKTGLRIDYEFVAAGEDDLGTLQSLRQLIGLGKIKKDLFVVSCDLVTDFDFTRAANLHRTYDAALTVLLAPMSDSLKESPVPGTRGKAKFEKDVVGLEPKTNRLLLFNSEADFEEVVSVRRSLLRNHPVIEVRSDLIDAHAYFISKWLVPFLFKNEGMTTIKGELVPLLARVQFKPDPRKKTVDIPETDVTSPMPMKSSSAPFRYVPTPESGGILVGDEHFTGEIGDGQDPIRCYGLVADGAFLVRANTVAGFMEANRQVRPTLSKAYQLDRDTFPHIPSGRFDNVLSDKVEFGEKASVRHCVVGQHCRVGAQAKVQDSVLLDGVVVGDGASVQGCVLCGSLEVGAGSTLKNCVVAHKKNLAEGAKHANEVLGTFVEI
The following text describes a protein:
Function:
Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes. Modulates the activation of caspases during apoptosis.
Subcellular Localization:
Cytoplasm, perinuclear region. Endoplasmic reticulum.
Sequence:
MQDPNADTEWNDILTQKGYLTPQGKSERIGRGGRRGAVHPPAVSEVLEISGKDYVQEVTKAGEGLWVILHLYKQGIPLCALINQNLGGLARKFPDVKFIKAISTTCIPNYPDRNLPTIFVYLEGDIKAQFIGPLVFGGMNLTRDELEWKLSESGAIMMDLEENPKKPIEDVLLSSVRHSVLMRRDSDSEGD
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVMVMASSAATTSTSSSTLLLRLLCLCTVLPVTLQAARPTNITIGALFAFDSVIGRSARTAIQLAVDDVNRDPTVLSGTNLSVIFQDTKCSGFVATIQAGMELMEKEVVAVVGPESSVIAHVVSNVANELRVPLVSFAATDPALASSQYPYLVRAVHDDRFQMAAVADIVSLYGWREVTAVYVDDDYGRGGVAALTDALQPTRARVTYKTAFPRGADRATLANLLQLANSMESRVFVVHASPDSGLDVFAAAHDLGMMVAEYAWIATDWFAAAAIDGAPAAASESNNNIIQGVLTLRQYIPDSDAKASLVSRLAGAAIPPSSNNDATVAANAYSLFAYDSVWIAAHAIDQFLDEAAGNVTFSADPNIRDANGSALRLSALRVFDQGDQLLRKVMLANFTGVTGQVAFQFDADGNNGTGSGTLINPAYEILNVAGGNTGVRRVAYWSNYTRLSVDAPTLLDDGGPPPNSTSTSTTPQQQQQMSNVTWPGGMTTTPRGWVFADNGTPLRVGVPYRTSDTEFVSKDDTSKDGVSGYCIDVFEAALQQLPYPVPVSFVLFGDGVTSPSYDELVQKVADGFFDAAVGDISIVTNRTRVVDFTQPYIDSGLVIVSTVKSSSSDEWAFLKPFTPELWGTFVAMCVFVGAVIWILEHRHNEEFRGSLWNQMRTLFWFSFSAIFFTQREETISSLGRFVVIMWLVVVLIITQSYTASLTSILTVQQLSTGIQGINDLLASNDPIGYQQGSFAGSYLINELGVKASRLRELAIEEYADRLQRGPRDGGVVAIVDELPYVELFLSSNCQFTMVGQEFTKGGWGFAFPHESPLAVDLSTAILKLSETGDLQRIHDNWLNQGTCDTQSQGTGGGALRLSVANFGGLFLICGVACGVALLIYFARILFQFYQYHRHGTTDGGAKEEEEDGGGGPFPDKERSMRWRLATRQSSFRDLMYFVDMKESEVKAAMAVRSSSTKSTARSRSDTSDGPSSP
The following text describes a protein:
Function:
Involved in the biosynthesis of mycocyclosin. It uses activated amino acids in the form of aminoacyl-tRNAs (aa-tRNAs) as substrates to catalyze the ATP-independent formation of cyclodipeptides which are intermediates in diketopiperazine (DKP) biosynthetic pathways. Catalyzes the formation of cyclo(L-Tyr-L-Tyr) (cYY) from L-tyrosyl-tRNA(Tyr). Can incorporate various nonpolar residues, such as L-phenylalanine, L-leucine, L-tyrosine and L-methionine, and to a much lesser extent L-alanine, into cyclodipeptides. Cyclodipeptides synthesized by Rv2275 always contain L-tyrosine.
Miscellaneous:
MISCELLANEOUS: The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site Ser-88 and the L-phenylalanine residue.
Sequence:
MSYVAAEPGVLISPTDDLQSPRSAPAAHDENADGITGGTRDDSAPNSRFQLGRRIPEATAQEGFLVRPFTQQCQIIHTEGDHAVIGVSPGNSYFSRQRLRDLGLWGLTNFDRVDFVYTDVHVAESYEALGDSAIEARRKAVKNIRGVRAKITTTVNELDPAGARLCVRPMSEFQSNEAYRELHADLLTRLKDDEDLRAVCQDLVRRFLSTKVGPRQGATATQEQVCMDYICAEAPLFLDTPAILGVPSSLNCYHQSLPLAEMLYARGSGLRASRNQGHAIVTPDGSPAE
The following text describes a protein:
Function:
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
Subcellular Localization:
Cytoplasm.
Domain:
The PRC barrel domain binds ribosomal protein uS19.
Sequence:
MTKEWISLGQLGKPFGIKGWLRLNVRETVLCELKTPISLKLSKPDFHFPEKEITLLEIRPHGGKFIVRFEGVTTPEEAAKWIGGFLFLPQKLLPKIETKNEFYITDLIGLQAIDESGKKLDWKLKDVQDNPAHPILVFVKENGEEILIPFLQVFVGDLDLEKNTIVLIQPEIWNEI
The following text describes a protein:
Function:
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Sequence:
MSTSQLEKMQDQVEIPEGVTVTQNKNMLLFEGPLGKTHKNFRNIPVKIEIADGKVNLKTIGERKRDYAILHTARSIIRNICEGLVEGYTIKMKVVFAHFPITVKVEGKKILIENFQGERAPRSTHIMGNTKVIPKGEDVLLTGEVWTDITQTAANIELTTKVKNKDHRVFLDGIYVYEKKKGIEK
The following text describes a protein:
Function:
Alpha-galactosyl-binding lectin with preference for galactose-alpha-1,4-galactose.
Sequence:
ACWKANSCPGSAFESKDRLRSFALLYCRYNYKPPYGQGAFGYASAVSTHGWETEAQCINTFEQIITSCHGQSNGGTLELNSGRLSLAFGNCEEL
The following text describes a protein:
Function:
Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility.
Sequence:
MEPQNQEPDLKPIYHQLLSPLSIFPRKATPPEPPKRSSPDVSALQSIPLAKLKVGPLCRQVSKRLANSGRAARVTTEDRLCLTEVILEELKCNWREPPIEPILNYENNQKLRKRLESYVLICSEQLFIRYLHLLVTLPTSRRVFTESATLSRLAVNLARDCTIFLTSPDVYRCLLADFQTLLNLKRTQGDIFKLRPPASPPGTFKLCPIPWPHSTGLDQVPCTSLNLNYLVQLSRPYDFPSEPEPDPMQELRSIPQLKSRQQLLWVPFMIKEKEIEGRSSQMVPLPSHSPPSSEIPPFPTSPVQPWLQRGQSMPCLCEGWSLADELGLLPLSPHPLTPLILASESKPLPFRDIVAEDLKQKMKIMTMEWSRYSLLDSGLPPLVRVLTRRLSAQQHIEELQQMLKNLQEEEASGKWDLLPPRVTPLQPQPVTVTLKVQDQVVVQVATVQLSERYFSDSFHLEGAGLLYNHLTGELDGKAIKEMDADRLIGNTTKEIYKELISRVSTGHFSFEDASQIEPSADKDWSSYLASSLLHQDKHMSFINQNLVGFYSRRASAQQLFSEKTPSLTLLQRHKSWDKRLNKGAWINWMKPSVSADDYFKYLASQESDFLHVIFQMYEEEAPVEIPTPVKESLDIQQPPPLIQYEEDLEFVPGMWDWNSVIEDSSRLGKAHFLSLQQRLEQLWVMLEVPEQSRLDMVIKYSSNARLQQLPALIRAWERVLKPIQKRELLLGRLEWFERQASDPNRFYQKPDLLLNRFLEENRFRSYIQKKLSQVESCLIPLLEKIESVFGEPVTFKGRSYLEKMKQDKVEMLYWLQQQRRIRNLIRTQKTIRQSSMSTRNNSQALMAPENTPITH
The following text describes a protein:
Function:
Mediates cleavage of dimethylsulfoniopropionate (DMSP) into dimethyl sulfide (DMS) and acrylate. DMS is the principal form by which sulfur is transported from oceans to the atmosphere and is a key component of the ocean sulfur cycle.
Miscellaneous:
MISCELLANEOUS: At least 10 million metric tons of volatile dimethyl sulfide (DMS) are released into the atmosphere annually by the dimethylsulfoniopropionate lyase in oceans. It is a component of the tangy aroma of the seaside and functions as a chemical attractant that guides various marine animals, such as sea birds, invertebrates, and some mammals, toward potential food supplies. DMS oxidation products act as condensation nuclei, causing water molecules to coalesce, with possible effects on local climate through enhanced cloud formation.
Sequence:
MPLILGGLAGAAAGYGAAAWLERRKPPPGKDPNIKHASLGVVRLDWHYHPLPGDVGSPDSFEYPVYYRAVPGLTFEICQSGKMSPEIQQNFKDAIEFLDKERGVSVITSDCGFFMWFQKEARLYTSKPVVMSSLALLPSLHAAIGTDGKIAIFSANSTSLGPMHDTVAKECGVDWDEACYVLVGCQDVEGFEAVASGEPLDLEKVTPGIVRKAKQVIAEHPDIHAILMECTQLPPFSDDVRAATGLPVYDAIVSADFFIRGFVDNPRFGLNDWHRPWDGHQEKYKLGDNVQDKEKLLHYKP
The following text describes a protein:
Function:
Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MDFFYKYLALVAIASLMVFILLFGQIPKLKYTVIGKLNRFFMVTIPYHLHVLDSRYADGRCSAAMRSLSNYVLYKNNPLVVFLYLALITIGIASFFIYGSSLTQKFSIIDWISVLTSVLLPYISLYIAAKSNPGKIDLKNWNEASRRFPYDYKIFFPNKCSTCKFEKPARSKHCRLCNICVEKFDHHCIWINNCVGLNNARYFFLFLLCTIQLLFHSILRLGYHFNALRDMRQYPSFLRSWWFAIKSEGELGSVFLISLICSVLVLCLLGYEFFLVYAGYTTNESEKWSDLAHLVKNRKVYMYYENGSQLLALDKDASNDAILVTSMSQIDNIYDNGFYNNFFSLVFPYRHLYSTT
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MWPLAFGSGMGFGMAYSNCQHDFQAPYLLHGKYVKEQEQ
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MMDRDKNQVTEKILDLTLEIIALLMGEDYVVVKKTDHKKDRPNLCLAQPLTSLVQEKKRDKSTKLSKKIHRRSNTEVPACYQNDGSCPTAGQLENSKRNMEQYEDVAMKNQDSLSPGYIPSTPERCRMPPFSQADTEANDKMARDYQVEQLDGIFPQQCKKKEIPTDINTGFPFTWEAKMEAFRMPFSEFSMNSKSVPQHSREIRNTKLNPLVETSKTSLNTPVKNKTLQEEARPGLQDFPDDFHPTTCFNEKTQHVSNRPDSTKFDLEADQIGGMAEKLYLCSECGKCFTNDSDLVAHQRVHTEEKAYMCYECGSFFTCSSDLAKHKQIHSGDHSLSESEYAKCPAQATGSYEKIQTGEKPFICTECGKCFSCSVDLAAHQRDHAVDNNAPSCELEAPLPKGITALPHQRIDARLKDFACSNCGECFTVKSELVKHHRIHVEQKPFACSECGKCFTQLSHLQRHQTMHSGETPCISAEPRERCDDSSTVSKPEKSQTQEKPFVCAQCGAGFPTSPELVTHEILHIAETEFVCAECGECFTNNSDLASHKVLHAGENPFLRPVGDKSLSYSSNYFINHSSAGDKPYACSDCGKGFAYRSAYVRHQRIHTGEKPFVCSHCGKCFTQKTHLITHQRVHKNNKHI
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MCEKSQTIKELLNAIRTLVVKNNKAKVSMIEKELLAFVSELDKKFKQQLNNFNELQQKIPLLQKANEEFALKFERMQREAQNQIQAKLDELNLKNKKELEQAKKYAIAKTLDQPLNIIDQFEIALSYAQKDPQVKNYTTGFTMVLDAFSRWLEANGVTKIKIEPGMEFDEKIMSALELVDSNLAKNKVVRVSKSGYKLYDKVIRFASVFVSKGNKKS
The following text describes a protein:
Function:
Bifunctional enzyme with lysozyme/chitinase activity.
Subcellular Localization:
Periplasm. Note=Secreted via the Gsp type II secretion machinery under conditions of derepressed gsp gene expression.
Sequence:
MKLNIFTKSMIGMGLVCSALPALAMEAWNNQQGGNKYQVIFDGKIYENAWWVSSTNCPGKAKANDATNPWRLKRTATAAEISQFGNTLSCEKSGSSSSSNSNTPASNTPANGGSATPAQGTVPSNSSVVAWNKQQGGQTWYVVFNGAVYKNAWWVASSNCPGDAKSNDASNPWRYVRAATATEISETSNPQSCTSAPQPSPDVKPAPDVKPAPDVQPAPADKSNDNYAVVAWKGQEGSSTWYVIYNGGIYKNAWWVGAANCPGDAKENDASNPWRYVRAATATEISQYGNPGSCSVKPDNNGGAVTPVDPTPETPVTPTPDNSEPSTPADSVNDYSLQAWSGQEGSEIYHVIFNGNVYKNAWWVGSKDCPRGTSAENSNNPWRLERTATAAELSQYGNPTTCEIDNGGVIVADGFQASKAYSADSIVDYNDAHYKTSVDQDAWGFVPGGDNPWKKYEPAKAWSASTVYVKGDRVVVDGQAYEALFWTQSDNPALVANQNATGSNSRPWKPLGKAQSYSNEELNNAPQFNPETLYASDTLIRFNGVNYISQSKVQKVSPSDSNPWRVFVDWTGTKERVGTPKKAWPKHVYAPYVDFTLNTIPDLAALAKNHNVNHFTLAFVVSKDANTCLPTWGTAYGMQNYAQYSKIKALREAGGDVMLSIGGANNAPLAASCKNVDDLMQHYYDIVDNLNLKVLDFDIEGTWVADQASIERRNLAVKKVQDKWKSEGKDIAIWYTLPILPTGLTPEGMNVLSDAKAKGVELAGVNVMTMDYGNAICQSANTEGQNIHGKCATSAIANLHSQLKGLHPNKSDAEIDAMMGTTPMVGVNDVQGEVFYLSDARLVMQDAQKRNLGMVGIWSIARDLPGGTNLSPEFHGLTKEQAPKYAFSEIFAPFTKQ
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.
Sequence:
MEHNGNAPSNPALDINPLTLFDIAKQEGRPLYTCAPMVRYSKLAFRETVAQYGVDLCWTPMILAKEFNRSVFARDSDFTTSPTSTPTIAQFGVCSPLEISRSTTLIAPYINGIDINCGCPQSWACACSIGAALMHKRELVAEMVKEAKSALKREGYEGKKTVSVKIRIHRDLRDTVDFIKTVQDAGVDFITIHGRMRSTPSSHPVNLEAIKLLNTHTTVPTVSNGDITSLRSAHEHTQQTSVSGVMSARGLLSNPALFAGYVSTPWECVDVFLNCVVRQPIPFKLVVHHLSEMCGSVGDGGNAGKSLLNKEERMRLMECRDMIEVIDFMDGVRSGVGGVGRL