lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.
Miscellaneous:
MISCELLANEOUS: Constructs encoding portions of SNCA and SNCAIP co-transfected in mammalian cells promote cytosolic inclusions resembling the Lewy bodies of Parkinson disease. Coexpression of SNCA, SNCAIP, and PRKN result in the formation of Lewy body-like. ubiquitin-positive cytosolic inclusions. SNCAIP isoform 2 is particularly aggregation-prone. Familial mutations in PRKN disrupt the ubiquitination of SNCAIP and the formation of the ubiquitin-positive inclusions. These results provide a molecular basis for the ubiquitination of Lewy body-associated proteins and link PRKN and SNCA in a common pathogenic mechanism through their interaction with SNCAIP.
Subcellular Localization:
Cytoplasm. Note=Detected in cytoplasmic inclusion bodies, together with SNCA.
Sequence:
MEAPEYLDLDEIDFSDDISYSVTSLKTIPELCRRCDTQNEDRSVSSSSWNCGISTLITNTQKPTGIADVYSKFRPVKRVSPLKHQPETLENNESDDQKNQKVVEYQKGGESDLGPQPQELGPGDGVGGPPGKSSEPSTSLGELEHYDLDMDEILDVPYIKSSQQLASFTKVTSEKRILGLCTTINGLSGKACSTGSSESSSSNMAPFCVLSPVKSPHLRKASAVIHDQHKLSTEETEISPPLVKCGSAYEPENQSKDFLNKTFSDPHGRKVEKTTPDCQLRAFHLQSSAAESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGKSLPSSPSSPSSPASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGSLSASSRARPKAKDEDSDKILRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKIPLEKRELKLARLRQLMQRSLSESDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLHLMIKKHTLASGGRRFPFSIKASKSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQPSPDSTAAQKVATSPKSALKSPSSKRRTSQNLKLRVTFEEPVVQMEQPSLELNGEKDKDKGRTLQRTSTSNESGDQLKRPFGAFRSIMETLSGNQNNNNNYQAANQLKTSTLPLTSLGRKTDAKGNPASSASKGKNKAA
The following text describes a protein:
Function:
Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MGRARKPPPALHRHCEGCFNRHCHVPVEPSVSCLVISCHLLCGATFHMCKESEHTLLCPLEQVPCLNSEYGCPLSMARHKLAKHLQVCPASVVCCSMEWIRWPNVDSETFLHENIMKETPSEECLDTALALQDQKVLFRSLKMVELFPETRDATEEEPDMNGDTSWEETGGAVGGVDARLAPNSCLPATSRQMMELSQEERDALAKTKEGMDLDKFGKWESMFSKEHAASVLTGSLGKSEDKNGDVAGKEQCSSNVRIGDAEGSAERRGPQESQKSQELPATMEMTGLAPWQDGVLERLKTAVDAKDYNMYLVHNGRMLIHFGQMPACTPKERDFVYGNLEAQEVKTVYTFKIPVSYCGKRARLGDAMLKCRPSEHKAVDTSDLGISVEDLPKSDLIKTTLQCALERELKGHVISESRSIDGLFMDLATQTYNFEPEQFSSETVLADLLGTAQPGGLHVELHSECVTRRHNKSSSAFTFTCNKFFRRDEFPLHFKNVHTDIQSSLDGWFQHRCPLAYLGCTFVQNHFRPPGQKAKVIYSQELKTFAIKPEVAPELSEKWKSDHLSGRDGKSLNSLTSLPLEVLQYIAGFLDSISLSQLSQVSVLMRNICATLLQERGMVLSQWKKKRYSHGGTSWKVHNQIWQFSSLFSKINSWEFNDVTSMSEHLKTCPFNIVERKTDPIRLTSMCQPQEKARESLVSTFRARPRGRHF
The following text describes a protein:
Function:
Part of the gluconate utilization system Gnt-I; low-affinity intake of gluconate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTTLTLVLTAVGSVLLLLFLVMKARMHAFLALMVVSMGAGLFSGMPLDKIAATMEKGMGGTLGFLAVVVALGAMFGKILHETGAVDQIAVKMLKSFGHSRAHYAIGLAGLVCALPLFFEVAIVLLISVAFSMARHTGTNLVKLVIPLFAGVAAAAAFLVPGPAPMLLASQMNADFGWMILIGLCAAIPGMIIAGPLWGNFISRYVELHIPDDISEPHLGEGKMPSFGFSLSLILLPLVLVGLKTIAARFVPEGSTAYEWFEFIGHPFTAILVACLVAIYGLAMRQGMPKDKVMEICGHALQPAGIILLVIGAGGVFKQVLVDSGVGPALGEALTGMGLPIAITCFVLAAAVRIIQGSATVACLTAVGLVMPVIEQLNYSGAQMAALSICIAGGSIVVSHVNDAGFWLFGKFTGATEAETLKTWTMMETILGTVGAIVGMIAFQLLS
The following text describes a protein:
Function:
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth (By similarity). Promotes cell adhesion (By similarity).
Subcellular Localization:
Secreted. Endoplasmic reticulum.
Sequence:
MEKISVSAFLLLVALSYTLARDTTVKPAAKKDTKDSRPKLPQTLSRGWGDQLIWTQTYEEALYKSKTSNKPLMIIHHLDECPHSQALKKVFAENKEIQKLAEQFVLLNLVYETTDKHLSPDGQYVPRIMFVDPSLTVRADITGRYSNRLYAYEPTDTALLLDNMKKALKLLKTEL
The following text describes a protein:
Function:
May be required for cytoplasm to vacuole transport (Cvt) and pexophagy.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Note=Endosome and other perivacuolar punctate structures.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.
Sequence:
MDSDTSPNPFASSPPSSPSPRPSLPPPVPRKPSSLVSAASGSPPPTHRASFPDPARHPKMGATVPGPKPKTGYCCSIDKDISAGEQVHIVDALKTTEGGTASYITYVIRLGTHTVRRRYSAFLSLHQSLTGLYPVLIIPPIPSKQSLTDYAVKGQSKAREDATIIARRKRLLEDFLQRLIRHPILGGEHVLHRFLEEDVSWSEVLHSPPISLLSKNPLHAPSHNPTFQPTTPTSPSEAPATTSYIAHHLLPTPSPSHPLRQPDQRFMDSEAFTEKFQSHFSGTMEKVNRRVTKRWGERAHDMSELGGIWNGFSLVEQGKLGDAIEKVGRAVDAEYLATAALLQSWEKTTTEPLHIYSQFATLIRARLSFRHQKHVQYELVQEALETQRDKLEILENAEREARRLEEALERGGSVLASPQLEPEAARDERERAQRRARASQGFGLLSAVKHSLSGMIDMDPEATRRANIAKTRDNISQLEDSYQAAAQDLKYASMTLQADLDRFQRQKVADLREMAINLSQVHRDWCKQNLEAWKAAQAAVREIDPHPNRPAQTQTQVQSQQSHAGPSTLHAQTEDDVSKLGVDAMKNEIERVEIEIADKPLPKPSLAETGGDGVVPSPQPRQENDTEEQEGHGPLGPL
The following text describes a protein:
Function:
Serine protease component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1R catalyzes the first enzymatic step in the classical complement pathway: it is activated by the C1Q subcomplex of the C1 complex, which associates with IgG or IgM immunoglobulins complexed with antigens to form antigen-antibody complexes on the surface of pathogens. Immunoglobulin-binding promotes the autocatalytic cleavage and activation of C1R. Activated C1R then cleaves and activates C1S, the second protease of the classical complement pathway. It is unclear if C1R activates C1S within single, strained C1 complexes or between neighboring C1 complexes on surfaces.
Subcellular Localization:
Cell surface. Secreted.
Sequence:
MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASQSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQKDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPANPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAAHTLYPKEHKAQSNASLDVFLGHTNVEELMKLGNYPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNETFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED
The following text describes a protein:
Function:
Acts as an essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules. NNF1 is required for a number of nuclear functions. Cells depleted of NNF11 or containing a temperature-sensitive NNF1 mutation have elongated microtubules and become bi- and multinucleate. They also have a fragmented nucleolus and accumulate poly(A)+ RNA inside the nucleus.
Miscellaneous:
MISCELLANEOUS: Present with 2070 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore.
Sequence:
MVNSHGIRYIRLKQVFNRALDQSISKLQSWDKVSSCFPQYVNSKQGAINVANCQRQLTEFWTELCQREFKEIMEERNVEQKLNELDELILEAKERYTDRDQDEVNKGPAIDELSSKELVECHLYSQRMHAIHEIDERLAKVNEMNDQLAQELKDLETQVEVEKNEIGKMYDEYLGSHTDQPANVLLVQSLNDMVLELKENY
The following text describes a protein:
Function:
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Subcellular Localization:
Chromosome.
Sequence:
MSETLSQDPELNTGYTNLAPSYPPTPATPSSTVQDGPPGANLPPFSTFSSDMDSNAVFNTATDRLFSDTRLLDISNWDYYTAEGRLLERGENGLSIISSQPQYRPWESKSVDSSTGFTSTTPVNTFADAFNQNGVVSKLPSFQSQFQTFNEPVTTSEPTLTTLTNLTPVSPNSSSPGSHSLTPLNSNFHTLSAVNRGYPLVPAPIQAREIPSIQQQFLDERHIQLYAHPPNLNSTIHFPAQNGTIIQNSPLISSPTVVTVLKSEPDLKLTTLQDTGLKIQNLPQFQNPMVSDNGIYNGLDKKLNGISATMSSPTRNDFRKKERRKMRASSLESSAESDGASSNLEMAENSGQVAAVSSTAGFKTHHSLAGNNAVDIDEISGGNVDKQVKKKRKRCGECIGCQRKDNCGDCAPCRNDKSHQICKQRRCEKLTEKKNLYGDASYLRGESRRGRGKGRGAGSYRGRKPSGPIASVPSGAPSGVPQESNGNVTIISNQQQPARPSPQPPTATVQQAIPVQQQSTMTPMPFYADPNRFPTPVWQADPTQAWTQGQFIQQIPAGTQALETYQQYPNGIYQATYQQPTFETNTFYTGAVQVLTRPPSAPNQTQVTPRPNSNYSHTPSPAPSNRQYQEYNPQNQNFVSPATTPSGNPESVSRPSSVNSTASNQNFNQSGANFTSVSSPSNYGNSGNAQPGYPQVNSSPQLASHSSSGYPGSGQFSGTSQEMWQEESVWQEEAKPEQNDRVNLNTRIKTMILSKQQENSEEKKVENTTGHFLWYSHHHRFIVNGGGGAKLTTTKPKQLPKKRYSSPYENEIPYCNCVRAGRGAAEPGTFYTHLGCANNLINLRHDLETRTGVKGRAIRIEKIRYTGKEGKTAQGCPIAKWVIRRSGSDEKYLIIVKHRPGHSCPSAFIVVCIVMWDGLPQPTSDELYTLLTSKLNKFGLANRRRCATNESKTCACQGLNPDTCGASFSFGCSWSMYYNGCKFSRSKFVRKFRLNVQPEEKIVEEKLQILATYLSPIYRSLAPVAFRNQCFFEEGGRECRLGLRPGRPFSGVTACLDFCAHSHKDSHNMVNGCTVVVTLTKHRKGEKPEDEQLHVLPLYVVEGTDEFDSQGGQEEKIRMGSIEVLTKFETEIRSSRAPAQKPEKRTKASKSSVFATPPTEPSYGYTNSYYVKLNQAAKKLFASYPSDHSIPPADGCYSSGFTNLPYYNPIDNYFSTVGNLLSSKLNQVQKTSSDNSDCFTDSSVGGVAIALEHGSVLLECARHEVHATTALKAPNRRSPTRISLVFYQHRNLNKSRHGWDEFAKRKLQKGLTTLFPKVRDIGMRF
The following text describes a protein:
Function:
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. In addition, promotes innate immune signaling downstream of dsRNA sensing. Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cleavage furrow. Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MANTVEADGSKDEGYEAADEGPEDEDGEKRSISAIRSYQDVMKICAAHLPTESEAPNHYQAVCRALFAETMELHTFLTKIKSAKENLKKIQEMEKGDESSTDLEDLKNADWARFWVQVMRDLRNGVKLKKVQQRQYNPLPIEYQLTPYEMLMDDIRCKRYTLRKVMVNGDVPPRLKKSAHEVILDFIRSRPPLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESPKNVGESSMVNGGLTSQTKENGLSAAQQGSAQRKRLLKAPTLAELDSSDSEEEKSLHKSTSSSSASPSLYEDPVLEAMCSRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRSLVPRITGVWPRTPFRPLFSTIQTASLLSSHPFEAAMFGVAGAMYYLFERAFTSRWKPSKEEFCYPVECLALTVEEVMHIRQVLVKAELEKYQQYKDVYTALKKGKLCFCCRTRRFSFFTWSYTCQFCKRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESCSRSEKPSTSHHRPLRSIARFSTKSRSVDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQSFYMSSAGPSEYCPSERTINEI
The following text describes a protein:
Function:
Catalyzes the NAD-dependent oxidation of vanillin to vanillic acid.
Sequence:
MFHVPLLIGGKPCSASDERTFERRSPLTGEVVSRVAAASLEDADAAVAAAQAAFPEWAALAPSERRARLLRAADLLEDRSSEFTAAASETGAAGNWYGFNVYLAAGMLREAAAMTTQIQGDVIPSNVPGSFAMAVRQPCGVVLGIAPWNAPVILGVRAVAMPLACGNTVVLKSSELSPFTHRLIGQVLHDAGLGDGVVNVISNAPQDAPAVVERLIANPAVRRVNFTGSTHVGRIIGELSARHLKPAVLELGGKAPFLVLDDADLDAAVEAAAFGAYFNQGQICMSTERLIVTAVADAFVEKLARKVATLRAGDPNDPQSVLGSLIDANAGQRIQVLVDDALAKGARQVVGGGLDGSIMQPMLLDQVTEEMRLYREESFGPVAVVLRGDGDEELLRLANDSEFGLSAAIFSRDVSRAMELAQRVDSGICHINGPTVHDEAQMPFGGVKSSGYGSFGSRASIEHFTQLRWLTIQNGPRHYPI
The following text describes a protein:
Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
Subcellular Localization:
Nucleus.
Sequence:
MEYLSYVYEKIFGGNPPTDDTQGAFHTPRKVICFGNVLLDRLVQLEDPQLLERFGLELGSKGELDMEKLNQLAAEASESSRCLTNPGGSALNTARILKQLGTDALFFGAVGADKHAEELRQIIRDRGIEARLQTVEDAHTGQCVCLMYQDNPTLYANIGASAQFEVQTLSHAVSHEGQSFLRPVERKQILYVEGFFVPQRSDVCDYIVQHLVRERRRLALNLSAPYIVRKNHQAMMKLARAAFFLFGNRQEFEALAEAAGGFRNVDELADHLLQSGGTKVIFVTNGSAGVQVITNYVEELAPPGPVSFEDFRAQRVEQLVDATGAGDAFVAGFLHAWLEKRSLGECIRMASSVAAKVVTQVGCNLP
The following text describes a protein:
Function:
Binds 5S rRNA, forms part of the central protuberance of the 50S subunit.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MRSQQSLEEIAELYGLLENIKKEYEDGIHSVLRKSNPELFSNPHTIPKLKKISINRGLGLAAQNTNILKKSITEFTRITGQKPLITRAKKAVAGFKIREEMELGLSSTLRGEKMYSFLTKLIFFTFAQIRDFRGLSVRSFDKAGNYTFSLKEQLIFPEIEYDDVDQVQGLSITLVLDSSTPKSRSKTVDRVLNGMILLKFLRFPLNDCGYYDKYESFGEITQVWDKKKHLRRKRWSQE
The following text describes a protein:
Function:
Catalyzes the conversion of lactate to pyruvate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKPRKVMIIGAGNVGTAAAHAFVNQKFVEELILVDLNKERVEGNRKDLADAAAFMPGKMDITVRDASDCADVDIAVITVTAGPLKEGQTRLDELRSTSRIVSGIVPEMMKGGFNGIFLIATNPCDIITYQVWKLSGLPRERVLGTGVWLDTTRLRRLLAEKLDIAAQSIDAFILGEHGDSQFPVWSHSSIYGKPVNEYSLEKLGESLDLKQIGETARDTGFEIYHQKGCTEYGIGGTIVEICRHIFSGSQRALTVSCVLDGEYGESGLAIGVPAVLSQNGVKEIISLKLDEQEQQAFANSVSVIKKSIASI
The following text describes a protein:
Function:
Thioredoxin reductase (TR) that exhibits both TR and thioredoxin (Trx) activities. Contains a C-terminal functional Trx domain. Functions as an electron donor for the plastidial 2-Cys peroxiredoxin BAS1 and participates in a NADPH-dependent hydrogen peroxide scavenging system in chloroplasts in the dark.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAVTRLAVAAALSAAPPSSRRRRAFFHHSCRPLPSSAAAAAKALRASAAPAVDEEAPASPPPSDLGKGVENLVIIGSGPAGYTAAIYAARANLKPVVFEGYQVGGVPGGQLMTTTEVENFPGFPDGVTGPDLMDKMRKQAERWGAELHQEDVEFVNVKSRPFVIRSSDREVKCHSVIIATGAAAKRLRLPREDEFWSRGISACAICDGASPLFKGQVLAVVGGGDTATEEAIYLTKYARHVHLLVRKDQLRASKAMQDRVLNNPNITVHFNTEAVDVVSNPKGQMSGIQLKRTDTGEESVLEVKGLFYGIGHTPNSQLLQGQIDLDDAGYILVEEGTAKTSVDGVFAAGDVQDHEWRQAVTAAGSGCVAALSVERYLVANDLLVEFHQPVREEKEKEITDRDVEMGFDISHTKHRGQYALRKVYHESPRLVCVLYTSPTCGPCRTLKPILSKVIDEYNEHVHFVEIDIEEDPEIAEAAGIMGTPCVQFFKNKEMLRTVSGVKMKKEYREFIESNK
The following text describes a protein:
Function:
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
Subcellular Localization:
Cytoplasm.
Sequence:
MFRMYIKNVHLINFRNYDDMYLELSPNTNIFVGNNAQGKTNILESIYYSSIGKSHRTNKDKDLIKWDKNNTYLRTYVSRERLDKTIDINIFKNGKKAITVNKIKIKKISELMGNLNVVMFSPEDLRIIKDSPGNRRKFLDIELCKINNVYYHDLVQYNKILSERNTALKNWNNKINDIIDIYDEQLSKYGAFIIKERNKYLDKLNIIGKNIHKKITNDLEDINFRYLTNIKDFDNAEKELLIVLKKNRKKDLERNSTSIGPHRDDFEVSINNIDTRIFGSQGQQRTAVLTLKFASLEIIKNIIGEYPVLLLDDVLSELDSNRQKFVLNSIDKIQTIITCTGIEEIDKYLDKKQSQLYLVNNGKIKRV
The following text describes a protein:
Function:
Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.
Subcellular Localization:
Nucleus.
Sequence:
MEAERRRQAEKPKKGRVGSNLLPERHPATGTPTTTVDSSAPPCRRLPGAGGGRSRFSPQGGQRGRPHSRRRHRTTFSPVQLEQLESAFGRNQYPDIWARESLARDTGLSEARIQVWFQNRRAKQRKQERSLLQPLAHLSPAAFSSFLPESTACPYSYAAPPPPVTCFPHPYSHALPSQPSTGGAFALSHQSEDWYPTLHPAPAGHLPCPPPPPMLPLSLEPSKSWN
The following text describes a protein:
Function:
3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGSLLRPVDLVNQPLGFQERYKILQKLFKQLQKAYAHTKGTNIDLERLATRLEVHVAKNSLSGQSYKFNMSILLRDVLKYKGDLSKIKINGRPLKGAKPHLSSIGNANSITTKSKAMEALKALILDSKVLEKNGYIVKEMQNKTNDDNSTQLYAPCLRCSSNFKKTDIMEKTLCRYHPLKRIYNRDTKNHQYPCCGETTDSVSFLRLGCKTFFHHVFRGESYDELCKISKFSSTDDIDGVENVLSLDCEMAFTSLGYEMIRLTIVDFFTGKTLFDHVIQPIGDIVDLNSDFSGVHEIDRTNCPTYKEALDVFLSENLINKNSILIGHGLENDLNVMRLFHNKVIDTAILYSRTKFKVSLKNLAFEVLSRKIQNGEHDSSQDAIATMDVVKVKIGISPSQNKWEK
The following text describes a protein:
Function:
Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MILTEATMNPEEIKAEYTSSLQDLTFNSKPLINVLTMLAEENLAHAPYIVQAIEEHLEKVQTNVKLPILYLIDCIAKNIGQTYMQLFSQNIVKTFCSVFKVVDEETRAEMFKLRQTWNNVFPQMKLYAIDVQIRMLDPAWPVTAQPTSNSIHFNPKFLKTTKTEIATPIVPETTTTPLDMETFTMQQKLIQKQKELIELQQKKLKLELLQTQVKLQKQLENNPNAVVGNNVPPRTQTGTGKTYTMIGNQAINPEDSTIGLIPRAAAHLLEELEQINSKIEYTVRISFIEIYNEEVHDLLNSSSIPLKIFEDPDNKGSVCIKGVKEATVLNLQEVYDWLNIGLVERQTASTNMNRHSSRSHSIFTISVLTRQLTVEGDELITIGKLYLVDLAGSENVGRSGSTELRAREAGNINKSLLTLGKVIKALAQKTQHVPYRDSKLTRILQDSLGGKTKTCMIATISAAANVWEETVSTLDYAQVARNVSNCPQVNENRKQANILKDLKDEISRLRKELAIARSGEGFYTSRENHERLCADVERLQTEVNEEKRKLEQVTKKNSELELAISEKDEKLRNVSQYCDDLKRELREKDLQEKRNKSVIDYFETREKEMRQAAEQLRKVCEVSTKHETLFCQKYENQRAISLKNATAAKNAYNLFGDSLRALQNATEDHIQRQNVSLSEVQANVGCLKENAWKMCKRLTEYSAKMQDDSQGDFYKLDESNLSRDFEQRLESMFTSQFFAIQKKAVQDLEQYNEEKMHEVETMTTRCINSMKQSLNDYMLCVNDIMKNQSSLIASVKGATNSDEVNILLKPEVAKQLMPEVAKQLIPAATRDTKSKSGLGTRAQQTTPKITPVNSALVAAATKPTRDPRLLRQQTEKTTNGTNNSSSTSVSLGSKSSILDSNNKVVTNTKSVRDNRIESRLVTNKDNAPPPKLDKSKTFLKSRQSEQKPNKPPRSKNSADNDSKPFSGKSSINLLDSPVKIKSDLKSPTKSPNRHKKKDHSTDKKGFKDAKRDRDNKGHKNDSLQTTFKGVKAKNRNYIRRNRSPSYSPEPNQDTDLRVSGPPEKQARLHPETVEEKSKLVAQTGMDVDLRQLNDVTKKRASSEGLENSNKKSKTEVFDALFGNEDTDLRTVLPVAQPERPPTPPPPIISLTDKEDSPKKSSDFDAVRAKLANATGRDKIMAKSFRKKRTQDEDLRVPPVSSRISDTIKKIIISSDDAQCIKTGTMSKEKENQLMNKIIAHIEQQKLEEAQLRDSEETVGNLQPVSDEELEFSEETDEKFGDKDDRVNFHKYSRDSRESRRGGSYWRGGKRRHWENPHMGPHPRSAIRPWLHQMHAWRPIGPNFNRQVHTPEHDFSSQEPDGKKSPETAVEVTVDSVNQDDIKTINIDAHPRDIRYYDETAIVFMNWDDPREISFQNGSRRVTFDDKDTYLLSFNEGYKELCINDTIHKVRLGAPSREIFIDGKPYECYFGGPGITIDLNGKMTVVKLDGPPPQVKIGTVKRTDLVAGKVNLIIDAKILVPVFLDAKVQKFVIDGETHTLKFVDALKTVLINDVPFKVEFGGLPKPITVHDKKHFIRFSVLPRGVKPGLVCIKDMEGVQAPETDESQDTALAVDINEPALPVFSRKKKVEDEQDRNSNSPHFFQSFMQQNNLDVLTSVMTSSMTPSATSGGYQVENVGPNTETHSMDAIPYVKPAPVLPSSLNINELFQKLVATGIVATQEPVAEPQPPPPVKTVRRSTMENLRPVTFNRPETLKMRQSLLYEALYSGMQCSSCGMRFPPEQSIHYSQHLDWHFRQNRKGKKNIRVAASRRWYYSLSDWKNYEEIEDLEEREKNYFDQQQLQAEGAGDDVDEEVEVPSVPADPDVQDAHCEVCQDRFDHFFNEEKEEWHLRNAVRVEDKTYHPVCYEDYQASLLEPAEECKMEEPEPEETKIEEANIPGLEIILDDDDEEEEEEGKFKDEEVIIEESDESKPSNELKEENENEEDGEDDDVIIHEVVPEKIEVDDDKEYDTLPPSDVPIKVEQIDDGFMDVEEGLIKIKNGGQIKIKSEPIDPDEEMLEVPREESSVPFTEPVQPSFTSSIDGNTEPVSSVPTTTANIGSKIKINISKPLPVIAPKEPKDISCDSVPSLEPVIDPSQPLPPGEEPVQLNIKPALRGIELKKLPPVQKGSELTGMCSIM
The following text describes a protein:
Function:
Plays a role as a neuroprotective and antiapoptotic factor.
Subcellular Localization:
Secreted. Cytoplasm.
Sequence:
MAPRGFSCLLLSTSEIDLPVKRLLSSVF
The following text describes a protein:
Function:
Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAPPSSGSECPARMAAGRRVGLGPRSHPAMAPWKKKRLRKRRTGASQARDSDSEDGEFEIQAEDDARARKLGPGRALPSFPTSECVSDVEPDTREMVRAQNKKKKKSGGFQSMGLSYPVFKGIMKKGYKVPTPIQRKTIPVILDGKDVVAMARTGSGKTACFLLPMFERLKARSAQTGARALILSPTRELALQTMKFTKELGKFTGLKTALILGGDKMEDQFAALHENPDIIIATPGRLVHVAVEMNLKLQSVEYVVFDEADRLFEMGFAEQLQEIIGRLPGGHQTVLFSATLPKLLVEFARAGLTEPVLIRLDVDSKLNEQLKTSFFLVREDTKTAVLLYLLQNVVRPQDQNVVFVATKHHAEYLTELLTGQGVSCAHIYSALDQTARKINLAKFTHNKCSTLIVTDLAARGLDIPLLDNVINYSFPAKGKLFLHRVGRVARAGRSGTAYSLVAPDEVPYLLDLHLFLGRSVTLARPHEEPSSAGAVGRDGVLGRVPQSVVDDEDSSLQTALQASLELQGLQRVANNAQQQYLRSRPAPSPESIKRAKELDLAELGLHPLFSSCFEEGELQRLRLVDSIKNYRTRTTIFEINASSKDPSSQMMRAKRQRDRKAITSFHQGRQERQDGPADPVPQRELPQKEEEDMVETVEGVFTEVVGQKQPRPGPNQGAKRRRKEASQRDQEFYVPYRPKDFDSERGLSVSGAGGAFEQQVAGAVLDLMGDEAQNMSRGRQQLKWDRKKKRFVGQSGQEDKKKIKTESGRFISSSYKRDLYQKWKQKQKIDDRDSEEEGPSNRRGPGPHRGGKRGRSQGASQSRASSVPTGHMRSELKTKEQILKQRRQAQKQRFLQRGGLKQLSARNRRRAQELRQSAFGRGAPTRKGKMRKRM
The following text describes a protein:
Function:
Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
Sequence:
MKQAFLSLGSNLGNRAEFLKIAVRKLKNTIGIEILKESTPLNTTPLEVIDQPEFLNQIIKIETSLNPEELLEVVLRIEKEMGRIRKVDKGPREIDIDILSYEEVKINTQGLTLPHHSLFTRPFIREILESIGEQSLYEHFTGGKYEKHT
The following text describes a protein:
Function:
May be involved in cell wall organization and biogenesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVMSRIRDTIARPFQNLTALEKVVQWLRLGTTLLIISFGLALTVGPLSSPRTLYMSRLDTYSADITTGLFTVLRESMEQSTSTEENNGVGLTTSELYILTAYTESQIKNVPQYITVSLYGRCDSTYTMVEVFDSEGNMHSVKNSTTKSTCSSIGTDYLFDYREVLESLGLDIILDYAYNKIGSQQAESSAYTTYMRSLKHKKANVLHLLYAVISFQVCMLFFMIWYYYIKGRFMNALKERALVHINSLLSLVVFIGGLISSISLAWVNYTIQSRINTELEAFGFSYHLGVTWFALLWCFAGLISVSCLAWSGLEWCISDNGTSYGGGIDDKFLGYQAGVFTDADLDDETSYSQRYPQRQSTSGEAELMRNSDTMATIRKTSDVDLNSENDANTSLDHGNPTANISNGGKHEPFATREEFELQDIRFRSSNDSEESMQRVIKPSSALQF
The following text describes a protein:
Function:
Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses. Involved in plant basal resistance. Involved in basal heat response through the regulation of the heat induced small HSP (sHSP) transcriptional cascade; [Cleaved BAG6]: Induces autophagy.
Miscellaneous:
MISCELLANEOUS: Overexpression of BAG6 results in a lesion mimic phenotype. Processed by APCB1 during lesion mimic development. The cleavage is triggered by pathogen infection or by pathogen-associated molecular patterns (PAMPs).
Domain:
IQ domain mediates interaction with calmodulin.
Sequence:
MMPVYMDPSQPCQMRPQEYYYQGFGNNSQHMAMDAPPPCHGSCVHGNFPAYWPPCYPPQVPYHQCCMNRSAFHPPHASYAPSCYVHPPFPVGYQPWFDVEKDVPGKHHCGKCSSQMCDLKKDRGVVIEEHEPEIEKGEAVLPVRSTNCPYPIIWIPHENARNQEYRSSLGLGKHNQPPAEVRAPDNMTIQKSFPESWRGCFPFDESSMKSLVQNQDSKKAQNGKTVEAPFDISKFKSLLQGQDMKEAQIQKNKEELGQLTYPTSWVPSRRKRDDVEASESSNEDRKKMQNGKTVEYPFDISMIKSLIQGQDVKEAQNQKNKEEPGQVPYPIFWIPSYGKRKDVEASESKESSNEGRNLESCPSDLHRNEGQITQAKGKEGNFECNVLSDAEEKSSVINIPVANHLQEPRNIPVKLSENHLPKPTEPTKRIAKNEPVKSTKKEQSSSSSEASKLPPVCLRVDPLPKERNGGSKSVSHPKRMEKSKETKIAAPLSSKKAESRTVPEACNVKCEDANAEMKMAEGSLNALRTEKGSVESNSNLQEESNGEIIKPCEAKENREQPAKKSFTEEEAARIIQSMYRGYDVRRWEPIKKLKEIATVREQMGDVKKRIEALEASTDQHIEEKEIVVNGELVMNLLLKLDAVEGLHPSIREFRKALATELSSIQDKLDSLKNSCASAEKEAVKEQVEIKSQPSDSPVNLEHSQLTEENKMVSDTNLEKVLRLSPEEHPMSVLNRTDEKQAESAAETEEGYGLFETLATDSKQATENAAAASSTTIPEKIGEVETVVPGNPPSADGNGMTVTNVEENKAMVVESLEEPINELPQMVEETETNSIRDPENASEVSEAETNSSENENRKGEDDIVLHSEKNVELSELPVGVIDEETQPLSQDPSSSYTREGNMTAMDPKTASQEETEVDHSPNNSKGIGQQTSEPQDEKEQSPETEVIVKEQPLETEVILNEQAPEPEITEPGISKETKKLMEENQRFKETMETLVKAGREQLEVISKLTSRVKSLEKKLSHKKKTQIRRRASKPMSVSPTDAVL
The following text describes a protein:
Function:
Nuclear serine protease which mediates apoptosis through proteolysis of the apoptotic inhibitor BIR1.
Miscellaneous:
MISCELLANEOUS: Present with 3150 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTISLSNIKKRDHSKISDGTSGESSLVKRKQLESATGDQEEEYTDHEIIIEPLHFANNNNTVLTDSENYLRWQNTISNVVKSVVSIHFSQVAPFDCDSALVSEATGFVVDAKLGIILTNRHVVGPGPFVGYVVFDNHEECDVIPIYRDPVHDFGFLKFDPKNIKYSKIKALTLKPSLAKVGSEIRVVGNDAGEKLSILAGFISRIDRNAPEYGELTYNDFNTEYIQAAASASGGSSGSPVVNIDGYAVALQAGGSTEASTDFFLPLDRILRALICIQTNKPITRGTIQVQWLLKPYDECRRLGLTSERESEARAKFPENIGLLVAETVLREGPGYDKIKEGDTLISINGETISSFMQVDKIQDENVGKEIQLVIQRGGVECTVTCTVGDLHAITPHRYVEVCGATFHELSYQMARFYALPVRGVFLSSASGSFNFDSKERVGWIVDSIDNKETPDLDTFIEIMKTIPDRKRVTVRYHHLTDQHSPLVTSIYIDRHWCNEFRVYTRNDTTGIWDYKNVADPLPADALKPRSAKIIPIPVNNEKVAKLSSSLCTVATMAAVPLDSLSADILKTSGLIIDAEKGYVLVSRRVVPHDCLDTFVTIADSLVVPATVEFLHPTHNFAIVKYDPELVKAPLITPKLSTTRMKRGDKLQFIGFTQNDRIVTSETTVTDISSVSIPSNLIPRYRATNLEAISIDCNVSTRCNSGILTDNDGTVRGLWLPFLGERLENKEKVYLMGLDIMDCREVIDILKNGGKPRVSIVDAGFGSISVLQARIRGVPEEWIMRMEHESNNRLQFITVSRVSYTEDKIHLETGDVILSVNGKLVTEMNDLNGVVSSADGILPSAMLDFKVVRDGNIVDLKIKTVEVQETDRFVIFAGSILQKPHHAVLQAMVDVPKGVYCTFRGESSPALQYGISATNFITHVNEIETPDLDTFLKVVKTIPDNSYCKMRLMTFDNVPFAISLKTNYHYFPTAELKRDNITHKWIEKEFTGNSQSEK