lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general role in the rapid activation and adaptation of the actin system to its multiple functions.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, cell cortex. Cell projection, pseudopodium.
Sequence:
MNYEDDNVESGQAGKSDAEYKADIANREKEVTKALNAGKPQDALNVALADPPIYTKTGAIKDQNATIVLNLLGSFKDKDVETSVETLNDDQLDILMKYVYRGLATGENSPIFFKWHECVLKKGGAGTIIRVISEKKTV
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MQTSRFWLSQGDSDSDSDDEEGKSEETFSDVALPPPRRDDDGLRKYLVSSSDSDELDTHRVVRPLKVKLNEKMWSTVEQIRNAMKINDWVSLQGCFENLNKQLEKVVRVSEFNKLPNAYILALMLLEDFLAESFANNKEAKKNMSTSNAKALYSMKQNLKRNNRQYAELILKCRENPECFNKEDANDNSKDDSDDDYDDIEINRLSSNEGKDDNHEGNQKEGLGEKEKVEKDKLMDKQFPKDPSEITWEIVDKKLKEIVASRGRKGTGRVERVDQLMFLTGVAKTPSQKLEVLCHVISAQFDINPSLLGHMPINVWKSCVNNILHVLDILQQYPNIVIGNLVEPMEEISNGADYDGTIRVSGDLVAFIERLDSEYFKSLQCSDPHAKDYVERLRDEQLFIVAAQNIQVYLERIGNFRAAAKVALRQVELIYYKPEEVYGAMRNLAEQAENEDGDANAIDGCSGPTPFVVIPEVVNRRPIFPPSSRTLMDGLTSLIYKYGDERTKARAMLCDIYHRAISDEFTVARDLLLMSNLQDGIKLMDISSQILFNRVVAQLGLCAFRAGLITESHDCISELYATGRVKELLAQGVCYGRYHEKTPEQERLEKRQQMPYHMHINHELLEATYFISAMLIEVPNMVASPYGNRKPVNKTFRGLLQFSERMTFVGPPENIRGHVMAAARALKKGDYQKAFDVISSLEIWKLLRNTEHVLDLLKLKIKEAALKTYLISYSACYGSISLEKLSVMFDLTQSHTQNIVSKMMIQEELHARWDQPTRSIVFQNAEQTRLQRLLSQMADNVSVIAERNEMAYGGKSLAEEVPRRRVDNQDPSKLGRLQKNLVPLQRPGYTRGGGGFTQAGLMHPKDSSSKGLHGNYGRVNKHAYPSVAGMVNLKKAVGV
The following text describes a protein:
Function:
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
Subcellular Localization:
Nucleus.
Sequence:
MKKGRGNMTRHKEEDVVYLFISKGRTMEHYSDDEEASEVNFGEEKVGFQQVMAVAGEWISDFLFLTLCRTFKDGKLEEFNEALSVFETISQSPSLKGAAGNEKTLICAFLSRVIHGKQLDVQFEEDEHVKPLMSAFKIWLNLENTVADESLFENITILLLVQSVAVCLEAGQRSAASSALKWLQEHHELPQNLRVKLSTVVAQRDPYHPFLMSFSFSRLKETTQSFLDAYLKRNPSDFLLKAATKMVQSSRNLQGLEDVDSQDGSHSETEDSAQENKKLKQKLLPTKKNAVRKPNPIKKPATEFSKSESSRKRQLLPTKIEEWSPDIVKKPQVSLTRLSKTGRFIFLFHTCIISRRYLQVYKHEHNSPPPPPPPPPSEICQMKTTKSLKPCNMVKTRKPPQKWTPQLDKFLTEGVKRHGRGNWSHILMDYDFEGRTGTMLKDRWRVLLKAHKVS
The following text describes a protein:
Function:
Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
Sequence:
MADKWRNVEHLQRKQANFLTNYGKVYGYGGRIDKMQEKEFSRLKGIVYLDHTGTTHYAQSQLDAYMKDLQTNVYGNPHTRSASSRLTTDTIDQLRFRILQHFNTSVECHSVIFTSGCTGALKLLAESFPWEDGSIFSYLEDNHTSVLGVREVAAKEGATIVCVSEEELLRCSNCDDKGTLQNRTMTSKNSNSMENCEPNNGVPCHFPAETDTFQGSEKLDSGNATSRSSGQPHLFTYAAMCNFSGRKFPLDWCSKIKRKQFSLCEESRGQWYTCLDAACYVSTNQLDLSCCEADFVTLSFYKIFGFPTGLGALIVRKDAEDLLRKTYFGGGTAMAVTSNGRFYIPRPNLHDRFEDGTLPFLDIIALRHGFDTMEKLTGGMLHISQHTFSLARYVYLQLTSLKHHNGQAVAVVYTDTEFDDINTQGGIVNFNLLRANGDFAGYSEVDKLAALHDIHLRTGCFCNSGACRRYLGLSNQQIKDNYQAGHACGDDKDLISGQPTGSVRISFGYMSTFEDAQFFLDFVQECFVEKSPNTTGAMNGQNEQYYNTELTLAPNVQSTNEGLDTEDDRRETEVNTRSTCAKTSATLQSSGLKNEPKKQADCLQEDRSVSLKKEIEEKSSKGQGLDSQTHSVRDSERSVPQTTWEKDEPTESREVEVPAQRHLTNIFLYPVKSCGAFQVKSWQLSARGLLYDREWMVVNESGVCLSQKREPKLCLIRPAIYLTEGVLQLSAEGMKLLNVSLTCARMGDVEASMCQSKVCGDRIMGLDCGNEAADWLTRFLGRPCRLVRQNPDSDRDCKVNRAGDDSSDGKYSLSLANESQYLLISRASVRELQQQIAANSNMVIPIEDLVLRFRGNLVIDSRQAYEEDEWSEVMIGGQQFQSRGQCSRCQMVCLDQATAQRSKEPLMTLFQLRSKKVPFGIHLVHNMAGTEPCCIQVGDEVTPVTMATD
The following text describes a protein:
Function:
Plays a role in development of both male and female reproductive tissues.
Subcellular Localization:
Nucleus.
Domain:
The cysteine-rich domain CRC binds zinc in vitro.
Sequence:
MGEDGGGGEFPPKKDGVEEGFPTKKPARQLDFTGGSDEHSLSKPAAPTVVATSVKPIISSSVPSTIRPGMTIAIGQVTQVRPTLPMATTMSNPPSQSQIVNAPIRHPIPESPKARGPRPNVEGRDGTPQKKKQCNCKHSRCLKLYCECFASGTYCDGCNCVNCFNNVDNEPARREAVEATLERNPFAFRPKIASSPHGGRDKREDIGEVVLLGKHNKGCHCKKSGCLKKYCECFQANILCSENCKCLDCKNFEGSEERQALFHGEHSNHMAYLQQAANAAITGAVGSSGFAPSPAPKRRKGQEILFNQAIKDSSRLSHFPQVNNGRTGGPTSGTSPSPVSRAGGNASSVPSKFVYRSLLADIIQPHDVRALCSVLVTVAGEAAKTSTDKRNEIENRVDDQTETSLASSAQDQPQGNNNAADVEMVATDHNQADKSGPEESNSDGVDASKVTPLSPATLALMCDEQDTIFMVAAPSPNGSVDPNGCRPNSQGQSEIYAEQERLVLTKFRDCLNRLISYAEIKESKCLSLARMHIQPPAIATVKTENGIQQQVPIVNGASRTNCQPTLNKPQPMQLMNTTSAAPATATNTQHLQKPPALSEKKDP
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MRDSSSFIQRNSQLPLSSNSRLSNINGPGSSARRPSLAPMRAIAQKRQSMTVDSFNNANSRFIAPSVRHSIAPSSRRSSTFVGGRASNASFLSQGVDQGDTRDPRPVRDKAFQSLCATNIVNYLINSGYPSPITIKNILSPTTKEFQSIFKYLYNKIDPNFSFVRRIDEDVKLCLKDIQYPYAESITRSHLMAIGSPHSRPVILAMLHWMVEVVQCIESLSTSQEEVPPDDEHFADKAFFEYLVKSYHFFLDDVPDDSSLTEELCAFLDSQNSGIGKEIENLEKNIQSMTEELEKDEELAAVLSQLQQENAVLQEDELKLQAIIERSELRIEKLQSKMGPLGEELNERNVELERLNQEKLSLQAQIEAQPISTTDLDRMTSEREQLSNGLNQISNRIQELRREILEAEGSVQTKTDSLEKLVQRYNTVAYRLGIVPSTAPRANDQSLELGLLEESEGCLNLDLKNIVRPFLINLRHNLTTEFHSEQSRSLELQESLDKINENVTDTKEELDALEIKIENTLSEYTMLKAKLSEEKSILNSESDKLEHELQQLKLNSQNTLLQLDQRIQALRIEYDHTTQTLEIMKGNAYKEVAFMLDEIIHFKLHIQNGLEELETDYEKELAEASK
The following text describes a protein:
Function:
Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Acts preferentially on (S)-ethylmalonyl-CoA but also has some activity on the (R)-isomer. Also has methylmalonyl-CoA decarboxylase activity at lower level.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSGKVVRPSAALLEVFKSWQGGAIRVQRNEKLKTRLDVILDRPEKNNCLSGEMMKQFGEHTELFSDDQNAIIVVSGVGKSFCSGADLGLIKDISDQKLGVQMFEYMSSILSLLHSSPAISIAKIHGHALGGATEICSSTDIRIAHSGSKIAFFQSKMGIVPSWGGAEYMEGIMGRGRALAAMGRANVMSAEEAKDQGYVDYVYKSEDEAENFINQVASAGLKVTRAQKAMLNAVKIGKTEQKQVLEAVWNGETHRNALQKQLEAVVKK
The following text describes a protein:
Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription.
Subcellular Localization:
Nucleus.
Sequence:
MMDPLYSVKEEYAGSSSGGGGGEPPPPVMTPPQPMEGLHDIGPPPFLTKTYEMVDDSSTDHVVSWNRGGQSFVVWDPHAFSTSLLPRFFKHNNFSSFVRQLNTYTELRYSKKVLSDLDVQMMLPSTCQLGFRKIDPEKWEFANEAFLKGNKQLLRNIRRRKTTNSQLLPTEQALGPCVELGRFGFDEEVDRLRRDKQVLMMELMKLRQQQQNTRSYLRSLEVRLQGTERKQQQMMNFLARALQNPEFVQQLIRQKEKRKELEEAITKKRRRPIDQGPSTLDVGGSSRPIKSEPLEFGEGSGFQVSELEALALEMQGFGRARRDQHEEETREGLEQFGNTDRELDEGFWEELFNEEDVSGNEDGEEEDVNVLAERLGFLDSSPY
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase.
Sequence:
MTETTEETIPTDQSEQPSVRPQFGNRFLSAGDDVFQHNAWDNVQWDEEQENAALEGVKKNSSVKLSDAEVTRLETEADQNWDRFYGIHQNRFFKDRHWLFTEFPELAPAKGPNTVPERVLPDGEPVKRAEEVSQESDGQQRSRTIFEIGCGVGNTVFPILKYSEEKNLMIYASDFSRQAIDIMCQSPEYDTNRCKAFVLDATADRWDVPFAENSIDIVVLIFVLSAIDPERMQHVVNQIARYLKPGGMVMLRDYGRYDLAQLRFKPGKCLKDNFYVRGDGTLVYFFTQEDLRTLFTSAGLVEEQNIVDRRLQVNRGKMVKMYRVWVQVKFRKPTDN
The following text describes a protein:
Function:
Gliadin is the major seed storage protein in wheat.
Miscellaneous:
MISCELLANEOUS: The gamma-gliadins can be divided into 3 homology classes. Sequence divergence between the classes is due to single-base substitutions and to duplications or deletions within or near direct repeats.
Sequence:
MKTLLILTILAMAITIGTANIQVDPSGQVQWLQQQLVPQLQQPLSQQPQQTFPQPQQTFPHQPQQQVPQPQQPQQPFLQPQQPFPQQPQQPFPQTQQPQQPFPQQPQQPFPQTQQPQQPFPQQPQQPFPQTQQPQQPFPQLQQPQQPFPQPQQQLPQPQQPQQSFPQQQRPFIQPSLQQQLNPCKNILLQQSKPASLVSSLWSIIWPQSDCQVMRQQCCQQLAQIPQQLQCAAIHSVVHSIIMQQQQQQQQQQGIDIFLPLSQHEQVGQGSLVQGQGIIQPQQPAQLEAIRSLVLQTLPSMCNVYVPPECSIMRAPFASIVAGIGGQ
The following text describes a protein:
Function:
Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin.
Sequence:
MIRVLLFAHLQEEAGTSELQIEKENITVAQLKDVVANEYNVPVSEPIMVAINEEYANEDDRVQSGDVVALIPPVSGG
The following text describes a protein:
Function:
The subtype A restriction (R) subunit of a type I restriction enzyme that recognizes 5'-AACN(6)GTGC-3' and cleaves a random distance away. The R subunit is required for both endonuclease and ATPase activities but not for modification. Has endonucleolytic activity that requires Mg(2+), ATP and S-adenosyl-L-methionine (SAM); ATP can be replaced by dATP, no tested molecule could substitute for SAM. Generates double-stranded DNA with no nicks, by cutting one strand then the other within a few seconds. Cleaves only non-methylated DNA, hemi-methylated and fully methylated DNA are not substrates. After locating a non-methylated recognition site, the enzyme complex serves as a molecular motor that translocates DNA in an ATP-dependent manner until a collision occurs that triggers cleavage.
Miscellaneous:
MISCELLANEOUS: Type I restriction and modification enzymes are complex, multifunctional systems which require ATP, S-adenosyl methionine and magnesium as cofactors and, in addition to their endonucleolytic and methylase activities, are potent DNA-dependent ATPases.
Domain:
The C-terminus (approximately residues 1003-1170) is required for interaction with M(2)S(1) and with Escherichia phage T7 Ocr protein.
Sequence:
MMNKSNFEFLKGVNDFTYAIACAAENNYPDDPNTTLIKMRMFGEATAKHLGLLLNIPPCENQHDLLRELGKIAFVDDNILSVFHKLRRIGNQAVHEYHNDLNDAQMCLRLGFRLAVWYYRLVTKDYDFPVPVFVLPERGENLYHQEVLTLKQQLEQQVREKAQTQAEVEAQQQKLVALNGYIAILEGKQQETEAQTQARLAALEAQLAEKNAELAKQTEQERKAYHKEITDQAIKRTLNLSEEESRFLIDAQLRKAGWQADSKTLRFSKGARPEPGVNKAIAEWPTGKDETGNQGFADYVLFVGLKPIAVVEAKRNNIDVPARLNESYRYSKCFDNGFLRETLLEHYSPDEVHEAVPEYETSWQDTSGKQRFKIPFCYSTNGREYRATMKTKSGIWYRDVRDTRNMSKALPEWHRPEELLEMLGSEPQKQNQWFADNPGMSELGLRYYQEDAVRAVEKAIVKGQQEILLAMATGTGKTRTAIAMMFRLIQSQRFKRILFLVDRRSLGEQALGAFEDTRINGDTFNSIFDIKGLTDKFPEDSTKIHVATVQSLVKRTLQSDEPMPVARYDCIVVDEAHRGYILDKEQTEGELQFRSQLDYVSAYRRILDHFDAVKIALTATPALHTVQIFGEPVYRYTYRTAVIDGFLIDQDPPIQIITRNAQEGVYLSKGEQVERISPQGEVINDTLEDDQDFEVADFNRGLVIPAFNRAVCNELTNYLDPTGSQKTLVFCVTNAHADMVVEELRAAFKKKYPQLEHDAIIKITGDADKDARKVQTMITRFNKERLPNIVVTVDLLTTGVDIPSICNIVFLRKVRSRILYEQMKGRATRLCPEVNKTSFKIFDCVDIYSTLESVDTMRPVVVRPKVELQTLVNEITDSETYKITEADGRSFAEHSHEQLVAKLQRIIGLATFNRDRSETIDKQVRRLDELCQDAAGVNFNGFASRLREKGPHWSAEVFNKLPGFIARLEKLKTDINNLNDAPIFLDIDDEVVSVKSLYGDYDTPQDFLEAFDSLVQRSPNAQPALQAVINRPRDLTRKGLVELQEWFDRQHFEESSLRKAWKETRNEDIAARLIGHIRRAAVGDALKPFEERVDHALTRIKGENDWSSEQLSWLDRLAQALKEKVVLDDDVFKTGNFHRRGGKAMLQRTFDDNLDTLLGKFSDYIWDELA
The following text describes a protein:
Function:
DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA.
Subcellular Localization:
Nucleus.
Sequence:
MSSGKQRTLFQTWGSTVQQNPDHPDLTARGKRPSGRRKAGTSNAAGKLKPKTSQNPPAPRGSLWGQIGQAAPAAGCWNGDEDDDDLMLVAVYEAEKSLESLQSASERDDGGAEPGITAGSEDLPGFDRTSADIWIYPTNYPVREYQLKISETALSQNTLVCLPTGLGKTFIAAVVMYNFYRWYPSSKIVFMAPTKPLVAQQIEACYKVMGIPQDHMAELTGSTQAQTRKEIWRSRRVFFLTPQVMVNDLSREACPASQVKCVVIDEAHKALGNHAYCQVVRELWNHTQQFRVLALSATPGSDARAVQQVISNLLISHIELRSEESPDIQPYSHQRSLEKVVVPLGEELARYQARYLLVLEKFTSRLTQLNVLSQRDIRNLTKYQLILARDQFRNIPPSHIGVAQQGVLEGDFALCISLYHGYELLLQMGLRSLFLFVQGIMDGSKEMPRARNELLRNQDFMELYQEMEAKFLKPSMAPPAGPEEPFLYSHPKLRKLEEVVLEHFRSWSEHTGPGDAEGAADRVCTRVMIFSSFRESVQEIAAMLSRHQPLVRVMTFMGQSSAGKGVRGFTQKEQLEVVRRFRGGGFNTLVSTCVGEEGLDIGEVDLIVCFDAQKSPIRLVQRMGRTGRRRQGRIVVILAEGREERTYNQSQSNKRSIYKSIMGSKQSFRMYTQSPRLLPEGVRPSLHKMFITSGQFQHRQTSCRASRGRRSDALIQESFTHPRGPGCPASRAKDGGLLSPEELSLWNSSLRLEEEEPQPTLPRSHFLSLKSEPPSPECVPTSSSRELSLWEWRCWQNRLFPTAMVDHSDRCRHFSQIMELIDCMRQEEKGECNYELELMPYLKKEDVIVCKGNKASCGETAVKGKRPRRLGSNLHPVHSKKKRSSSSSIDMEEVDRDFRTPGVSVSKQTSSVCMPESTEKCLSSEDAQAINEPKGCGMESEPSETFQAGDIESECIIIPDKRKDPGAGSADHCSSPELEALHQSAKLSPHIGYANKTDESCSDIEAMFYFPKCTTFSFEKCPDKEIPHNVKVILANVKELLERSPPPEPDLDFDLINVEPPLDSKSQPINTFQITFSLTGELEVPCGEKESSDIVLSGSDLKLNGVASHGVMTKEAAEVNKRPTGHAVLKACSPSWDVIFDEVPEENPTHDEQDMGCRNSKLQLQAGTPGDGNDKATGKQYCQSHSFKADPKDESMDLFEDDDLFLQVSVPDPVVSDDKSPRPNAPAGPVGETDGFERDGLACRDLTVQEKTAFVAEGPTAPYPSSVADQQQLPQDEGQYNCSQELFSVNFDLGFSMEESEDELPEKGNASPHEAKESASSSATPTSERAAETWLIPNEEKHGSSSRCWMDPRGMNCVTPLIHHTERETAPFSVSKGVSVLSPVITNQDQSLLAPPDITDQDQSLLGPPGITNQDRNLLAPTAASTPTPFATLTSPRGSGKLLKRTQTSRPDPSFLGSKLWSPLKGHTQGHLKRALLKAAGPTSENRPSDPLHKGGSSGDSDEEAVFRGHRKRTKANPLDSPDVSDVDSPIQVAQRRRAPFISLEESGDEQLSDQDFKDSLLRRPRRPRPHRNSTPPHGAKVAIRAAREFLDEEAELSEEGGAVSSDEACDSSEELDHSLAGFVVDNIQPSQGLNDSAMHGVYLKSVRSPAVHNKYKMVYKPSYDLEVCSQVTEQDESYMEDSFVVQGGEEEEEEPGDSDEEEVCAVELLPDDTCIGGRKLYPTRRRVRLRRAQGLESGPELFAREVKKPKASRIIVPEDTSEEEEEGKMKDVKEDAGGDAKALPRPGEPPLTRLPVFKTPQPEERGSAIQEERRRQQLSLQASVSEALDFQPASSKELSAAQQQPGCSGVGQGARPPLSQPVCVLADSRGIAGGPEVLSCLRLRHGVTAQVCSLGACDFIVSNRMAVERQTLSEISSSVNRGRLAERVRALQGSFDRVCLIVEKDRTKPGEVSRVFQRSRYYDSTLAALIRAGTRLLFSSGPEDTAALLAELARVEQRKSNAIAVPTEVKGQRHQALQFYLTLPGVSYIAALNMCHRFSSVWHLVNSAVEELAAGACVSRPRAEEIFRCLRYAFHPDLLPHRPAGGAKSSGL
The following text describes a protein:
Function:
May function as a linker between membranes and the actin cytoskeleton.
Subcellular Localization:
Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Associated with membranes and the cytoskeleton.
Sequence:
MEYKSIEKSIVRESKVRNVFSKVCKKELFYTNLKVNSASEELLKSSKSLFAYPSSIGGGSCLSITKLSNHGKVPDTPFCIKGHTDPISCFEFSNFNDYVIATGSRDCTIKIWEVPEEGLIKDNLVTPLITLPKQQKRVTGVYFHPSVDSLFMSSTLDYTLDIWDLSSTGEQSSVIQKLTGHEDLIMSVGWNTWSGGDKLATSSRDKKMRLYDPRSQSTPIQTISTHEGAQGFKLCWADSNGLELICTVGANKSAQRQLYLWDPRQLQSSQPLVSKDVTTDSSILSPYYDFGTNMVYLGGKGDGIYYYEIEKNNAHHIGKATFGNVTQSAITLLPKSVVDVNICEIDRFLRLTAANSVEMVSFMCPRKSQLFQEDIFPPCPSGDPTTDCSLWFADKQLKVIPHTISMKPDGVQSIYEVSEEEGGKSKEKDKLEQLSKLSIGNSGSGGGGGDGDGNGGDSPFITEGIVKQEIEGWLFNSYENRYLKIVKDKIYCFLNEDSAQAIWDSPVLNIKYVDIYDEDENTSGEEWSLRFNIILLNGKEHRMECSTVKQRDAWCQSINAYREMKQQVDQSVVSPTMGEFHLVNTTPVAPSPMVISENKNALQKFSVPSPKEQQQQQQQGSESPNSTTPKSSTPTQTRHHSVLSRNPSYTSLKSSGGFSKPSPSSSTSTPPSTFASPLSIAQTSSTTTTTTTTTTTTSSSSTPPPLRANNSTSSTPLNSSTGIKQSDIVIEGNLTELIPGLLWNSNTEKWYVVSEGMLYSYKNKSLKQLDPLETIHLEKAISAHKTKEIFTIQGFSFQLSTPNRIIHLLAKTKEERGSWLSVLRQNLKSSGETKPKSVLTRASTMDELISSPMSDDESNTNEGGVEEEEEEQPLEGQLSRKLPGIFSMWGQCFVALLAEDLFVSRNKLSTTPELRIQLSSISLIKKISPNEFTLYDSMNQVVCNFRTIAPTAEFDDCTRWIDGLEAARKRSIDIIKMFGINEKEVLSPLPSSSSIPSSGSNGNLLDPSADDLTRYLDLTAIKNGKQKILIQVKGKRKIRVRMVKLSTSSLNCHNSFILDAGPRIFVWAGSKTSRVNKAKALDFANRIRTKERGGKSTLIQLDQGRDEQSFDFWEILGGNSSDPIATTPTPEEQDTESIKTTIYRVGLDVKKNSLRARLAWEGTDWKLPNKEILNTKFVYVVDCVTEIFVWVGKESSSIQRKMATKVALVLQAQKDRVDWTKITRLTEFGENNLFKEKFANYPGMLPISTTRQEIKSHVATSKVEHKIETLASRMTTPFIDNEALFTIPIDEGGRVKVWKIEDYEKIDHPQHLYSQFFSSDSYIVLYTYMQNNKEAHVIYYYLGRDSSINEKGTSAYLTVDLNESLVGACVQTRVVANKECKNFLNLFKTKMVIHKGKYNNYDPKKPSLYQVKGLDKIDIRAVQVEFSSSMLNTLHVSILRTPEKIYIWHGKFSLDAEQNSALSIAENFNSTSAPIEILKEGSESNEFWSAFESTGGRQKYFNDIMIQSSSIPTSFTYKPRFFVCSNASGIVEVTEESPFSQDDLDIGSVCILDVQSHIYLWIGSRATHRTKRASMEVVLNFIETSKLGHSKEHTKVLIATPFEEPIGFKSYFRAWCTSKYPKNKLPLVEKDGIPVEQVLKDYLKEIYTYEELLADPLPAGVDSTKLDTYLNDEDFEKVFKMTRTEWLKIPAWKREGIKKELFLF
The following text describes a protein:
Function:
Part of the multimeric TFIID complex that plays a central role in mediating promoter responses to various activators and repressors.
Subcellular Localization:
Nucleus.
Sequence:
MSAPQQQHNIQQQNIQQNIQQQQPQQNVQQPQQVIGQPQQQPVYKPVIQINKTLPQQQPQQQIPQQQQIYKQAPQQIYNQISPPIQQNINSPTIVNNTPPTPVVTTPTTTTTTTQSNYSTNRPNININPASPISSTTIASPVTPTVLTSTPPTTITTPTTTTTTSTPTTTSTTVITSGTGQPSLGSIESSIESVLRKNNLVNTTNFSPVQNIGTTTPPPSSTVVGITSPTLTQTTSSPITATSITPTITSIPTTTTTNTTSPMSIGTPSSTTPVVSSVLPTTPTTTSVTAPITTTPPSSSVTTTTTTIPTTTTGSNNSVQITGTNPMVYDSRQMANNSSNITSNPTSTINTPTTTTTTTTATSNSTGTILSKQKKEKEKEKERREREIREKENKDQQDKDKGLNSGGGGGGGIGNNNNPNNSNNPNNSNNPNNPNNIEPEVLGKRKLIELLQQISPNEKMDEDAEDILSVLADDFVESTVAFACTLAKHRNSTTLEVKDLQCHLEKNWNIRVPGFGNVEQYKTFKKPHFPENHKLRVAAMKKSIALTQASSRKQQIREFKEQQKELKEQQQQEELKQQLQQSKKQKLQLQQQQLQQQQQQLQQQQQQQQQQQQQQLQQQQQSPSSKF
The following text describes a protein:
Function:
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate, using ferredoxin I (PetF) as the reducing agent.
Sequence:
MQTLPSPVQATPTETAIVRRKTRPVPIGSVVIGGGHPVAVQSMINEDTLDIEGSVAAIRRLHEIGCEIVRVTVPSLAHAKAMEEIRDRLYKTYKPVPLVADVHHNGMKIALEVAKYVDNVRINPGLYVFEKPKPNRTEYTQAEFDEIGAKIRETLEPLVISLRDQGKSMRIGVNHGSLAERMLFTYGDTPEGMVESALEFIRICESLNFYNLEISLKASRVPVMIAANRLMVKRMDELGMDYPLHLGVTEAGDGEYGRIKSTAGIATLLAEGIGDTIRVSLTEAPEKEIPVCYGILQALGLRRTMVEYVACPSCGRTLFNLEEVLHKVREATKHLTGLNIAVMGCIVNGPGEMADADYGYVGKQPGYISLYRGREEVKKVPEAEGVAALVELIKADGRWVDP
The following text describes a protein:
Function:
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity). Within the HOPS complex, contributes to the normal development of gut granules in embryonic and adult intestinal cells. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes. Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (By similarity). Possibly has a role in clearance of apoptotic cells during programmed cell death.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTEFGWRRFNFFDRSVVFDKDDPKQKFMGLKDVAVDCWCSSGGSVYLGEAKGGVFQLTNQFSEYYWKAYQKSLASLHSADKYLFSIGEDDETVNTLLKIWDPERVEKNTPHVMRTIRMSPLNPTSSSPACSIAVHSSLQSVVVGYTDGTVLFYQGDVLHDKSLNSRWIKVRDSSVGEGSVTGLAIAVLPASKTVVFVITQKHVHSYVLENGRTVIAHKKHDANGATADCWTFDESTGQLIVASREMLFFYDADQCIDMDGGEVGRCLQLGRGHEKLQLVASGQYLALLTKHHSLIQKERDSEFMTMLSVYDIKGQYVGFSCSLPNLCRLFIAGSTMLVLSHDGLLSELIEKNLATKLDILVKKSMFDVAVLIAKNSRDGGDYLKGIHAKYGNYLYGKGDYENAIQQYKETIGMLEPSYVMKRYLDSSKIKELCIYLECLHDAKRDNEHQTKILMNAYAKQGEKKKLMEFVNKITDGTRVSRMRDVFEILLKWNYLAEASLLATKFQMHEDALNVIIHHMHKYTMGVTYISKMPIESVIEMTGKFGRDLLIHARDDLMHMLWEKIQENTDAKKNNFMRIFDIFMGDMDASRVFLSYIENQTNEHDEFIIPILECQMRLFKVNSDWSQERLEEDIYRFINKKNEDAALQMAQLFDCTPVIEHILMRCHKSKELMMYHQKKRDLEAIIRLCQSCSKEEKRRLWLDALSFIGKHATARDELIIIDLLKEIEASEQIHPLVVLELLAKNEHLTISSVRDYIIAWLRKQQIIIEEDRNTIKENNKAMGELDGTVESLKFNAQIMQVTKCSACDTPLQLPTVHFLCKHAYHVHCFESYNMDGSDKCPACQTTRDTTRDEEISYHKFQKELAEASNGMELIAMYLQRGLFDEKTKKTKKSEAKKDPFSTGRASTTTNPFDDDEVTTISRTMSTVSSNMATPSRQRSITRKDDDSTNPFFNSDSGTRLSTYDESKNPFGAPAPSTNPFD
The following text describes a protein:
Function:
Functions as a component of the ISW1B complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing.
Miscellaneous:
MISCELLANEOUS: Present with 5820 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSEAIFQPTDIVLAKVKGFSAWPAMIIPNELIPDNILKTKPVSVHKGKSGSDKKANEDIDADMESEARDREQSEEEEDIEDFGESEANPEKFIIYTPVLKFRKNDTLKSTYCVKFFCDDSYIWVKPMDMKILTSEDCRKWLSGKQRKNKKLIPAYEMAMRGKNGIDIWEFVEYGSYGKPDEEEYVEEEEEENEPEKKAIRPTRSSSRQRQKRASETEKSEGGNSNKRKRVTRSTRQQAIDASEEEEEEEEEKVQEAVRKRPQRTKTKKVVVSKTKPNPKTKAKKEKPKPPKPIKYHFEDDEDWSIVGLGPQDLSIEKTMDPIAKKLSQKKNLEKHVEIKLDLEDKLAGINKLLCDVLCSAINQAVSIKDDFEIILDELQIALDTRGSRNEFITIFQSNNSLLLNFRILFNLRKRELNKWDLWDRFQDIFKHIYSYQFIPDTEDWQLEQNMEIEEMDREKPSFSEDVKEEESKVGA
The following text describes a protein:
Function:
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
Subcellular Localization:
Nucleus speckle. Cytoplasm. Nucleus.
Sequence:
MVWSRDQRRKVALENPHMQNSEISKRLGYQWKMLTESEKWPFFEEAQRLQAA
The following text describes a protein:
Function:
Chaperone protein that facilitates the trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16. Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity). In addition, acts as a potent IFN-inducible suppressor of pathogens including lyssavirus rabies, influenza A or yellow fever virus. Mechanistically, associates with the viral replicase, binds viral RNA, and thereby suppresses viral genome amplification that replicates at the endoplasmic reticulum (By similarity). In addition, restores antiviral signaling by interacting with and sequestering influenza A virus protein NS1.
Subcellular Localization:
Membrane; Single-pass type III membrane protein. Cytoplasm.
Sequence:
MVVDFWTWEQTFQELIQEAKPRATWTLKLDGNLQLDCLAQGWKQYQQRAFGWFRCSSCQRSWASAQVQILCHTYWEHWTSQGQVRMRLFGQRCQKCSWSQYEMPEFSSDSTMRILSNLVQHILKKYYGNGTRKSPEMPVILEVSLEGSHDTANCEACTLGICGQGLKSCMTKPSKSLLPHLKTGNSSPGIGAVYLANQAKNQSAEAKEAKGSGYEKLGPSRDPDPLNICVFILLLVFIVVKCFTSE
The following text describes a protein:
Function:
Catalyzes the decarboxylation of (R)-methylmalonyl-CoA to propionyl-CoA. Could be part of a pathway that converts succinate to propanoate.
Sequence:
MSYQYVNVVTINKVAVIEFNYGRKLNALSKVFIDDLMQALSDLNRPEIRCIILRAPSGSKVFSAGHDIHELPSGGRDPLSYDDPLRQITRMIQKFPKPIISMVEGSVWGGAFEMIMSSDLIIAASTSTFSMTPVNLGVPYNLVGIHNLTRDAGFHIVKELIFTASPITAQRALAVGILNHVVEVEELEDFTLQMAHHISEKAPLAIAVIKEELRVLGEAHTMNSDEFERIQGMRRAVYDSEDYQEGMNAFLEKRKPNFVGH
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSETQITYPKRENKWNDVFFYFLFNTAAICSVILAIYNTLKSTPDYSILKDHLSWINLMPPIHLFIPFVLFAGCILSYCFILLLNRYTKLCVYTFSIVLPIIAGTIMLVASIFTIHQGIYTFVISLIFALCFFISPLIIFFSRSKLPLTIEILKHSTFTLLHNTSILFILVPIVMVLCVLILVVICHSLLVQYLSGTTQNNDYYPPTSFYPTFLFQVFMCYWMGNVVNGIFTVCSSSVIAHHYLNNNEIGGDFTESLIHSTTKSFGSIVLGSLLLSIVQFLRFLYEITNQEEDDDNKSSFTCLIHCCLDCILRLIEDILQYINRMTYVIVGMHRTSFIQSAKTACSLIKDNITMAIMEDTIMGSVIFGLTLVSGIISGCIGSLIMMIIFRSMVHSIIAFIISMIIGFLVTGFFMNAVQTSTDTIMLCYTEDMLVYNGIHCEKFGDIVNEFDQYHSFNSNNPILPEEANDLDGVYTS