lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10. When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MNFLSHLDSSQIFSTEDAYKPFLFELISQDKMRELLQPAFKYILTVAAQSYPRWLLLAYRHDKLIYALIMAIIDYHRLCRWGGSFTETFYGLCRSGVKDSSSTTTSLSPSQIRKSLAALILVPLVKSKLDEIHERLAQRRTSERFVGFVPESDSETQSPSTNLFNSSSNLEKLGKIAVKVFKAGYPYTNAAYSAIILGFQIAYMYGKTPYYSPWLYLCGLKLKRLSVSDYQEYDRKARQTRGQALDVISNSRGMQFVARVLQFVAGELVGVIQYAIPMGILLFKFLEWWYASDHHKSANMLPIPPPPDPIPPHIDGTKLPKDAHICPLCSKPRTNSAMLSTGYAFCYPCIFNYVSEYGKCPITFIPLRIDNLRKIYHT
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 6960 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MSIVGRNAILNLRISLCPLFMGKRSFVSSPVSNSAKAVKFLKAQRRKQKNEAKQATLKASTDKVDPVLGRADTPFITRIMAELKEPLVLSKGYNIEEVDKFLAAIESAKRERAELSGLNTEVVGIEDIEKLEDRREAILRILSMRNSENKNAIKMAVELARKEFERFPGDTGSSEVQAACMTVRIQNMANHIKEHRKDFANTRNLRILVQQRQAILRYLKRDNPEKYYWTIQKLGLNDAAITDEFNMDRRYMQDYEFFGDKILIRDSKKVANQKRKEIRKQKRATF
The following text describes a protein:
Function:
Facilitative glucose transporter that plays a role in glucose metabolism and regulation of longevity. May also play a role in lipid metabolism. Glucose transport activity of isoform a is competitively inhibited by mannose, galactose and fructose, suggesting ability to transport also other hexose sugars.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein; [Isoform a]: Basolateral cell membrane; Multi-pass membrane protein. Note=Detected on the basolateral but not on the apicolateral membrane of intestinal cells.
Sequence:
MSEKSRSDTSATASLSDSSKSPSSYSTPGTTTQKIIFPDGKLTKCLAFSAFVITLASFQFGYHIGCVNAPGGLITEWIIGSHKDLFDKELSRENADLAWSVAVSVFAVGGMIGGLSSGWLADKVGRRGALFYNNLLALAAAALMGLAKSVGAYPMVILGRLIIGLNCGFSSALVPMFLTEISPNNLRGMLGSLHQLLVTIAILVSQIFGLPHLLGTGDRWPLIFAFTVVPAVLQLALLMLCPESPKYTMAVRGQRNEAESALKKLRDTEDVSTEIEAMQEEATAAGVQEKPKMGDMFKGALLWPMSIAIMMMLAQQLSGINVAMFYSTVIFRGAGLTGNEPFYATIGMGAVNVIMTLISVWLVDHPKFGRRSLLLAGLTGMFVSTLLLVGALTIQNSGGDKWASYSAIGFVLLFVISFATGPGAIPWFFVSEIFDSSARGNANSIAVMVNWAANLLVGLTFLPINNLMQQYSFFIFSGFLAFFIFYTWKFVPETKGKSIEQIQAEFEKRK
The following text describes a protein:
Function:
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.
Subcellular Localization:
Cytoplasm.
Sequence:
MASAAVDQGEVRADEGPTPASPSGPGYELIGKSGVKIIDIAAKGLEVTANSISGLRVEPLPGPSAFVKPKSIYFQQQTRKRRWDMVESHPSVSILLYHKGFKAALLVRQFRPAVYVSETKRVQLEEGPTATLPLTGAFTYELCAGIVDKPGLKLEEIAKEEIREECGYDIPLQSIRKLTSWLSAVGISGARQTCYYAEIDESMRAGRGGGNLVEGEEIDVVALPVDQIDKFIMDESIPKSTGVI
The following text describes a protein:
Function:
NHase catalyzes the hydration of various nitrile compounds to the corresponding amides.
Sequence:
MTENILRKSDEEIQKEITARVKALESMLIEQGILTTSMIDRMAEIYENEVGPHLGAKVVVKAWTDPEFKKRLLADGTEACKELGIGGLQGEDMMWVENTDEVHHVVVCTLCSCYPWPVLGLPPNWFKEPQYRSRVVREPRQLLKEEFGFEVPPSKEIKVWDSSSEMRFVVLPQRPAGTDGWSEEELATLVTRESMIGVEPAKAV
The following text describes a protein:
Function:
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.
Subcellular Localization:
Nucleus.
Sequence:
MLPYIGHNSYQQHQFPLPEMEIPEKWKLSYEQEAITAPACPRCASSNTKFCYYNNYSLSQPRYFCKGCRRYWTKGGSLRNIPVGGGCRKRSRSRQNSHKRFGRNENRPDGLINQDDGFQSSPPGSDIDLAAVFAQYVTDRSPSSTDNTTGSDQDSPITTTTHALESLSWDICQETDVDLGFYGEFNNLTQKTKEDQEVFGQFLQEDREEIFEFQGLLDDKEIQEILECSFSEEPDQLVSQGSFMINGDNWSSTDLTRFGI
The following text describes a protein:
Function:
Probable lipid transfer protein (LTP). May improve freezing survival. Seems to control the flowering process and lignin synthesis. Has an auxiliary role for germinability and early seedling development under low temperature and salt stress conditions, probably in an abscisic acid- (ABA) dependent manner. Confers resistance to Botrytis cinerea and exhibits anti-fungal activity, at least against S.cerevisiae, B.cinerea and Fusarium oxysporum, probably by increasing their membrane permeability.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MASKNSASIALFFALNIIFFTLTAATDCGCNPSPKHKPVPSPKPKPVPSPKPKPVPSPSVPSPSVPSPNPRPVTPPRTPGSSGNCPIDALRLGVCANVLSSLLNIQLGQPSAQPCCSLIQGLVDLDAAICLCTALRANVLGINLNVPISLSVLLNVCNRKVPSGFQCA
The following text describes a protein:
Function:
Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSLAPRKRRTDRNESPSLPVRSYSDDDKQRTPKPPLSAPYLRHEYIISWSTATALTVVACIVRFWRIAHPDQVVFDEVHFGSFAAQYIKREYYFDVHPPLAKMLNGLAAWFVGFDGNFGFDQIGDSYTEASVPYVGMRSFCAILGTLTIPVVYAIMRESGYPVGIAAFSAALILFDNGHITQTRLILLDAHLVLFMALSLFCYVKFHQYRYQEFSRAWWGWLLATGFWLACTLGCKMVGLFTFATVGAAVIWDLWEILDIKKGHSMSYWTRHFCYRAIGLVIVPFFVYLSFFWVHFKILKFSGPGDSFMSPAFQETLEGNELLLNAQEIRYYDTISLRHKDTKQYLHSHEERYPLRYDDGRISSQGQQVTCYPHNDTNNHWQVIPTKEIPESGRGRIVRHNDVIQLKHVNTQTLLLTHDVASPLMPTNQEFTTVSPDKEDKRNDTLFKMVLDDAHDGEAWKTLSGHFRLIHVPTKVALWTHPKALPEWAFGQQEVNGNKNAAERSTLWFVNDIVEDGQGFDFKNRTVHVEPKAVKKRAFIKKWFELQVLMLQHNAGLTSTHPYQSTPIEWPFCLSGISFWTRNEGQQQIYMIGNLLAWWICAVSVSVYVGVVAADMLARRRGIHPIEDGVRNRLYRNTGFFLGAWAFHYFPFYLMNRQRFLHHYLPAHLASVLVAGSVMNFILIEAVNYPISIAGPTTRLRPAVRAKLNKSAKMVIAGLLVVVIGVYLFLSPLTYGQSMTGEEVNRRKLLSTWSLHFEAKKTHSMDE
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MADKSPSTRAKKRKVSKKSKKSWRKFTDIKDVEEHFEEARRDERTGGPASEKPDASLFFVDTKSKEPETDGTQNKRSRKRKLLKCDQLLLPDTRLKPIGSKKRKVKQSSKKKTLLVNDSSSDEDEPPPKPLVKEKSKKPRAKNKEVFDLWGKEDTPKDVNEHYLKVTGKMKVKMPKSARRKVTELTAVEVCHPGASYNPTFEDHQELLLNANEIEVKKQKENEKLERQVRFLTKDEAAALPTWEEEMGEGLFDDKSDDDKVDDDDDDDEDNEEEVMNGPILRSKQKTSQQKRKELEEKQKQKELEAEKEQKLKENDIFRIKTIKKEIASAENKMAKRRRKKEEEKKTSLQKTRKLGRHTYVNPNVEIQLSDEISGNLRKLKQEGNLMTDRFRSLQKRNIIEPRVPVLPHRKYALKEYEKRSHRKPCINEIWEENAKKKNTR
The following text describes a protein:
Function:
Lysosome fission factor. Recruited to lysosomes by RAB7 (RAB7A or RAB7B) at scission sites and homooligomerizes to mediate the constriction and scission of lysosomal tubules. May sever membranes by inserting amphipathic helices into one bilayer leaflet. Lysosome fission is required to maintain their steady-state number, shape, size, composition and function, and to accomplish regeneration.
Subcellular Localization:
Lysosome membrane. Note=Recruited to the lysosome membrane by RAB7 (RAB7A or RAB7B).
Sequence:
MSETYAKRLSAILLDAVTDKDPQMQEQVCGALCDFGESKPAEVLSACEEHLRLHEKLAHPYRTIILRAMEIVVSNHISELDKDTARAIILLASNEMTKVKELVSDWQQAASSVLVAVGRRFISSVMEELLSKFQPGLLPHPCTVHTLASLSVSNVFGVVPFLTSILSTMLPMLGAAKHDSMKVVFCCALQRFSESILEYLANLDQAPDPTVRKDAFASDIFGAYDILFHQWLQSGGAKLRLAVVEALGPMSHLLPSEKLEEQLPKLLPRVLAFYKKHTETVHVSKSLGQILEAAVSVGSRTLDIHLNSLLAALHAQICVPVESSSPLVMSNQKEVLRCFTVLACCSPDRLLAFLLPKLDTSNERTRVGTLQVLRHVINAAAAQMEVKKPVILSSMKLPLLDTNNKVKRAVVQVVSAMAHHGYLEQPGGKAMVEYIVQQCALPPEAEIQKLGADSEALAADSVRAISVSTLYLVSTTVDRMGEVLWPYLLEFLVPIRFTRALSPLCRSLVHLAQKRQEAGAHAPLIQYNGNVHLPSPYAITTRLLAVSSHPYVGDGRGAASLRLLNVLHQDIHPALGQRWVTAIPLLLEHLDEYSEETLSQKEWEEKLLVFLRDSLAVVSDNTWVCHLTLEMCKQLPNYNGTPLEKNFLYKCVGTTLGAASSKVVRKHLRELLETARYQEEREHEGLACCFGICAISHLDDTLAQLDDFVKSDVLRKSAGIFNLFKNRSESEANKVRSALILCYGHVAAGAPRELLLARVEADLFWNMSECFSTKVLGIKVETQDPALRLSLVQSVCMATQAICSSAHSSSFHLSRKAELVAQMVEFIRAEPPDSLKTPIWKKAMLACTYLVTLEPALEEQVQADLIHSCLHRVMAVLPEPEEGDSPQEVSAAPTVGGDPQESLYLDTVQVLKDLLTSLLLWNMTPLGLQVMLEHLSPWIKSPRGHERVRAVGLSACLLQFFLQHLQISALVPFHNLGLLIGLFSPRCADLWPATRREAVSCIHSLLYLQLTCVGFSRDYQDDVAEQLLSLKDGLVHPDPAILFHTCHSIAQLIAKRLPPDHLINLLLTLFESLGDPDKNCSRAASVMINCLLKERGNMLQEKVPEIVSVLRSKLQETQEEHILQAAQHSVFALATHHCASVVSNLLGSPLPFDSHTCTLWRALALEPGLAAQVLGLLLEKISKDVLFEESQAFLLSSTPDRVATLLPLAATCALHEVASAPASGPAVLELYPQLFVALLLRVSCTVGVQPPRQLQAKERRSASSGLASRSLEPCSSAVDALQAVLVRGGNEDVVQCMELDGGWQLLRTSAGHEEGVTRLASAMAKFAGPRLPLVMKLLFTTQSSMYEVQRVTSTAFLAELLSSNVVNDLMLLESLLYNLMARQKDTSARVRRLVLHGLANITLGSPDKVQTHSPQLLTAMIGGLDDGDDPHSLVALEAMVGLARLMDLVDAWDLHAVLLHIAVRIRPFFDSERMELRSVSIGLFGHLNKACRGDCKDVFLEQVVGGLVPLLLHLRDPHAPVVTACRFALRMCGPNLECEELAAVFQRHLQEGHDLHFGEFLNTTCKHLMRHFPDLLGRLLSTSLFYYKSSWEDVRAAAPMLTGFLVLHMEAEQRPQVDLEQLLTALQLLLKDPALKVRLKAVKTLGRLVKFA
The following text describes a protein:
Function:
DNA polymerase II participates in chromosomal DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MRKQKQNLLDEIELKFNVEWVRSQKELLAWVANMKVISTYDESEKEFTALLVYVITQNGTIFLKLMYDIPPYFYVECNQEHITELAMHLENKYEKQILKVDIIERVDLDKANHLIGKKEKFIKLQFRLIQDLVQVRNLIRARCEKNRRNVDENDMLIKKPSTSKDIQDQLIGVREYDVPYHCRVCIDTGLRCCKWFKFVLKERRIAECIEVKEMMSMPELKYLAFDIETYKQPLKFPDAKNDQIMMISITHSQNSILITNMQTLGQEVQNFDYAPKPEFATQAIIYNQPDEKSLLLKFFQVILDYKPNIISSFNGDRFDWPYIEERCLTHGFYLEQEIGIKKNEENNEYYGRYIIHMDCFAWVERDAYLPQGSHGLKAVTKAKLGYQPIEVDPEKMVPMALQDSQQFAGYSISDSVATYWLYRKHIHDFILALCTIIPLSPDEVLRKGSGTLCECLLMAQAFQREIIFPNKTTTLLERFHDGHLIDSETYIGGKVECLRSGIYRSDIDVEFKIDKECMQSMWSTVDSLIRFVGKIENETFSEEEIEKCSEQIRSKLDVLINRGEVFKEKPLIYHLDVAAMYPNIILTNRLQPVSIVGDQICSQCYFNQPQNRCQRQLEWQWKGDFFPLKRTEYEFVKQQLEQEQTEKERKENEEKKKQMLKEGLDTRRLQLKGFSDLAPDEQIKRIKQRVIEHCKKTYKTIHHHSVELKKDTVCMRENDFYVQTVRDFRDRRYEFKELVKVYKNKLEQAKKEGVGVKECHDFMALYESLQLAHKIILNSFYGYVMRKGARWYSMPMAGIVTHMGSQIISTAKQRVDQIGLPLELDTDGIWCLLPSGFPEDFLIKSQTGRNLKFSYPCYILNELVYEKYKNNQYQWLKDPNSFEYGIRSEMSIFFEVDGPYRCMIIPAAREENKQLKKRYVVYNKNGSIAEVKGFEIKRRGELQIIKQFQQELFSEFLKGTNLTECYQACAEVGKKLLRILMTGGEGISQQELLDLIGESRVLSKEISEYDNKKGVAITAGKRIAEYLGSDQVRGGSLNCQYIITKLPHNTPVNERSIPLLIFESSFETRKKYLRKWLKEPQLQDEDLTLSKIVDWDYYIERLKNTILKLLVIPAALQNIENPIPQVEPPEWLLKKLREKASGLQQTKINQYFSQINKLAHQLAQFKFQPMDIEENKQLSNKKKLQINEDNQKQLHNQYNMETDFKNFLQVQKQIWTKEFRNKQQNKNINGRGNLKNMIKFNKQQLLNSVWQVLQFYEVEPGLFLTWILLENGTLTSVQIQVDRTIYTNQLTKEPELQTIKKTLPRDKKVHYLYPLTMDESAFQLEHKQLFQYEANPNTESLYEHKIPLIFKLVTELGAMCKVNRQYVQQQKNVFKFEDLQIVYEQPSQQQYLDRFQNSFYQSSYIILHLQLQDNFGVWSVFFNDEVLIIIVRKSEEKLNRQDLNQYIKSVQEQFEFKRKQLNKNFEMPIPEKNKITVQSMKDDKLAIDYISNNFETRGQSMKLCILQSNKELTYLQSQGLQFLCLKIPTFCIPNLHRESRKEFQWDINTVKQQLESYCKLRETIAQHIKYCKYVKVPLCNLTASNLGKTDVFKTDIEMLNYTTDIFFQRVLRQKTSCLSWYGSGLGRDNRDLVPTEFTKTYFDNPGIYIGYTCEIDILHFSINTIAQSEEIKNLDKEASQLVGQNGKSDMLDNLDELGGAKIAFRLLQMLVSSWLDDIYAKGEKVSDDHILNINIWIYSGLSPLYDPYLGKLLNRLNFKFFSILTNKLKEFGIKIVKASPTKLLLYTGKQQKDMAKSLIEYIINTFQQSNLFKHVTFKAQKFFTSLIYKDKHNYLGKDVDYNTDDVDFDYKLKLQDFLPPILSSLFVRLLFEILLKVEELRSSQIEEINILPTNLQISRITNLQTDIINLLVQYINSSYSQRIYDIIIDQSEKYKKEKQNYETYLEQQQQTVALTGKMKRCNIEDDEEMQQEVQEDYEQDSFVVGDEDLDETPKQIEIEEELEFQEDGKVSNFPKLWHLRSALGSRIDLEKHEQAILRTFIYLCAILSVDEEVHQQMKRIKNVCCKTVKVSESSKEAEFEDPCFDLILQNVPCYQCYMVQEVNVFKDIWKCEGCKNDYDLDTMEKLICQFVEQQLLFYQIQDLYCVKCKQTQDYSFQKICSCSAQFQLKSDQFEKCFIRTPTYFFDSLLQLSIEKNLHGLKTLVSSINT
The following text describes a protein:
Function:
Component of the cuticle of the larva.
Sequence:
MKFVIVLACLLAVVFANEEADVVKSDSEVNLLDFNYAYELSNHIRAVQTGALKEHDNWVVSGEYEYVAPNGKTVKVVYTADETGYHPKVVEA
The following text describes a protein:
Function:
May be involved in plant development processes.
Sequence:
MEQYEILEQIGKGSFGSALLVRHKHEKKKYVLKKIRLARQTDRARRSAHQEMELISKVKNPFIVEYKDSWVERGCYVCIIIGFCEGGDMAEAIKRANGVHFSEEKLCKWLVQLLMALDYLHANHILHRDVKCSNIFLTKDQDIRLGDFGLAKMLTSDDLASSVVGTPSYMCPELLADIPYGSKSDIWSLGCCLYEMTAHKPAFKAFDMRALINKINRSIVSPLPTMYTGAFRGLIKSMLRKNPELRPSASELLSHPHLQPYVLKVHLKLNSPRCNNIPTRWSDLNFVKKTRFVEQDVIGRRRSFSNDRALNPSVSETEQESLTYIQREQEIPSYLFEKFTEFSVGFDNEEITTVDKSAAIKFPTAVKTPRVTPAVSGTPRKHTIPAKKSQTGQKHDLVPISKTPVRKSSYSLRRESLPLPTRTAALVTPYRANVGLLRSINSPDVSVNTPRIDKIAEFPLAPSDGPLFCVRGTSSTSAKCSSSSIDSANHSITKDNCTVQTLDKVITTSNGSDQSLGVGRDDGEGSEHDHAAASTHSSSDSRQRRFNTSSYRQRAEALEGLLEFSARLLQHQRYDELGVLLKPFGTEKVSPRETAIWLAKSFKETQA
The following text describes a protein:
Function:
Regulator of biological processes that recruits a histone deacetylase to control gene transcription. May play a role in the entry into mitosis, negatively regulating the cell proliferation. Formation of stable complexes with geminiviridae replication-associated proteins may create a cellular environment which favors viral DNA replication (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MQLFKETKIILLSSMSSLGSGSPEEIERSWCACVLYCVSKLGNAGKAKEDRGITLRQILRAFDLKIVDFFKEMPQFCIKVGFILTGLYGSDWEKRLELQELQANLVHLCSLGRHYRRAYQELFLLNDGKPANNSSELNVQQASEYYDFGWLLFLVLRNQASSAVKNLLTSTTELVSVLAVLIIHIPVRLRNFSIEDSSCFAKKSDKGVNLIASLCERYLTSEDELSKALQKTNILIKDILKKKPCSDVSECQQGSLSFIDPEGLTFFKNFLEEDSLKSSLQVLEKEYVNGLDTKGELDARMFANEEDSLLGSGSLSGGALKLPGTKRKYDDVMASPTKSTASRAPMSPPRFCPSPNGNSFCNSKMAPFTPVSTAMTTAKWLRSTISPLPSKPSGELLRFFSACDKDVTDDITCRAAIILGAIFTGSSFGERMCTSLRNTSGMDAIWTEQRKMEALKLYYRVLESMCRAESQILSGSNLTSLLSNERFHRCMIACSAELVLATHKTVTMMFPAVLEKTGITAFDLSKVIESFVRHEDSLPRELKRHLNSLEERLLESMAWEKGSSMYNSLIVARPTLSAEINRLGLLAEPMPSLDAIAVHHDISLGGLPPLPFHKQPDKDEVRSPKRACTERRNVLVDNSFRSPVKDAIKSKFLPPLQSAFASPTRPNPAAGGETCAETGIGVFLSKITKLAAIRIKCLCERLQLSQQILERVYSLVQQIISQQTALFFNRHIDQIILCCIYGVAKISQLALTFKEIIFSYRKQSQCKPQVFRSVYVNWPSRSRSGKIGEDHVDIITFYNEVFIPTVKPLLVDLGPGTSPNRNNEPKSGGDAASFPESPRLSRFPNLPDMSPKKVSATHNVYVSPLRSSKMDTLLSPSSKSYYACVGESTHAFQSPSKDLNAINTRLNSGKKVNGRLNFDVVSDLVVARSLSDQNGSSAAAMAVFGTKTPVKGEQQDP
The following text describes a protein:
Function:
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus. Nucleus.
Sequence:
MFPQFAVSAASFSRATALLTRVGTDAHFYDDPEAPNLAILLDSKYEAEKTEGMKRLIALMSQGRDVSNFFPQVVKNVASPSLELKKLVYIYLVHYAEKRPDEALLAINSFQKDLSDLNPLVRAWSLRAMSGIRVRVVLPLVVMAVNKCARDPSPYVRRCAAHAISKVFAMDREQHLETLEELIALLMNDNSPSVIGAVAAAFSVVCPDRLSLLGPRIQKLCELLPDVDEWGQVVLIDNLLRYAIGRHGFPKGSFGFLNAQQAKGLVQDDVYLEKREGQLLEMLQVGDAHRAVRDKRKAEVEEKDGGGKVSGFQAANELWLRNTPQEMDEPEEVSKDIQMLLQNTQPLLWSRNSAVVMASASVHWLLGRKEDVKKIVQPLVFLLRSAPETQYVVLANLSTFVKLAPSMFQAHYEDFFITSADSEQIRVLKLDILCLLATETSIKYILQEFQAYVRSPDRQFAADTVSAIGRCAVRLPSLAAACTIGLLLLARSGSVVSNDSNDVGKEDQEAQIKGHTTRYTPVRTLRSQNNGEKSSREAVVVTQAVLALRIIVQQRPLENEEVLARLIRGLDKLNVQRARAIVIWMIGEFSETGTLVPKMIPVVLQYLAGTFTKESDETKLQIMNCAAKVVLRSQASSDSASQVALLVFDTVLRLASQDLNYDIRDRARMLQQLLVLHLQGLSERSQKVEGDVADKLTMLRVQESSSILESVEGDDGEKTSSFNVDKPRNGKSSAGLMKLAEHIFLVPKIAPAVLSLTPDRSFLPGSMSHVVQHIAPDYRPLPQPFSIDSADSLTHVRHAATQQADSEVDSSSNGDYSGSGDEKYGNMSSPRSSSNGEHVEEENGESFLSGSGDSSSEIDMYQHSGRSKSASHPSSHSRSHRSGHEKRSSRDVEPLISLSDTEAGVTSGTQGRDVNQQPLSESPTAGFGLSSKDLDSWLGQEEMGTTSGSASGYANLSLGKIAVEPKTHTLLDFTNGGGLEVKYYTERIAVSSSEDQVYVKLLFHNRGSESLSGITVKEVESSKTSFETSESETSSSIPVKSEQVVSGLDPGSKAEGKLVVQFLHHFNPVKLSIVCNDKTYLVKLVLEVGVLIRPVPLSPEAFNSSQSRITGMHESSRRCILKVRHPSQGVPVTEDKLLVVARSIAQKVLTSAHVSLVSTTIPIGDSFVSEQAIKGGGVQGLRLRFSGKTLAESVLCLIEVAVLTETVTEIDCEQLEVLMKVNCENTVFGLTLLQELSKALSSSE
The following text describes a protein:
Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAEVDEFSAFRHENDVSIEQRIVYFINSLIVALVPVYLYHAIFFMSIDDHMIIYGSVTLFAAIVLTFAYNNIYRMKRLKLSASREHISIASKNKVGDKKKFAAAQKEVQALVTSHEAIAASIMYNNAVFLICVSIFSFIIFKNVPLVYNYIISISLGAGLTSFLSTSSKH
The following text describes a protein:
Function:
Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MDSKEKALKTAEFLHDKKAQDIKILELKELTIITDYFVICSAESTTQVKALAEYLQETMQQEGYKLYGIEGFSHAHWVLMDYGDVIVHIFLEETRRYYDLERLWLDAPRIQIEKITSDKSRAVYR
The following text describes a protein:
Function:
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
Sequence:
VFFQMWIFGYGSLLWYTDFPYEKVQGGHVGGFVRRFWQLSPDHRGTPEAPGRTVTLIPSSDDAGCWGLAYKVPEEHQKTTIEYLDHREKAGYTCERAWFRPDDGSPPFLVHVYISGTEDNEFHAGPTEDEEIASTILVRHGPSGPNVEYALKLALVLRSHSPHSDDDHVYSIERRILELAEKTGKGKESLEKLGYRLVEGKWAPPESNSFSLLKKT
The following text describes a protein:
Function:
Hydrolyzes deaminated glutathione (dGSH, 2-oxoglutaramate) to alpha-ketoglutarate (alpha-KG) and cysteinylglycine, alpha-ketoglutaramate (a-KGM), and no activity on glutathione or L-glutamine. May function as a metabolite repair enzyme.
Sequence:
MKPYLAAALQMTSRPNLTENLQEAEELIDLAVRQGAELVGLPENFAFLGNETEKLEQATAIATATEKFLQTMAQRFQVTILAGGFPFPVAGEAGKAYNTATLIAPNGQELARYHKVHLFDVNVPDGNTYWESATVMAGQKYPPVYHSDSFGNLGLSICYDVRFPELYRYLSRQGADVLFVPAAFTAYTGKDHWQVLLQARAIENTCYVIAPAQTGCHYERRHTHGHAMIIDPWGVILADAGEKPGLAIAEINPDRLKQVRQQMPSLQHRVFV
The following text describes a protein:
Function:
Putative RNA-binding protein. May be involved in regulating gene expression during embryonic development. Seems to be involved in endoderm formation. Ectopic expression results in endoderm formation in the absence of mesoderm induction.
Sequence:
MRVCAPGAELGAVSGGSSTMAAQCGGYMNQSDPGSNSERSADSPLPGSEDDSPGSAAPHDPEWREERFRVDRKKLETMLQAAAEGKGKSGEDFFQKIMEETNTQIAWPSKLKIGAKSKKDPHIKVSGKKENVKEAKERIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEETGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARVRIRELLPLVLMFELPIAGILQPIPDPNSPTIQQISQTYNITVSFKQRSRVYGATVIVRGSQNNTSAVKEGTAMLLEHLAGSLASAIPVSTQLDIAAQHHLFMMGRNGCNIKHIMQRTGAQIHFPDPNNPLKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEEIEVEPQCITQLMEQLDVFISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLDSSGVTITNQSTISCPIPMNCHGLDILAAGLGLSGLGLLGPNTLSVNSTTAQNSLLNALNSSVSPLHSPSSAAPSPTLWATSLANTSNATGFPAIPHLMIPSAAQATLTNFLLSGVPNYGQNTPSPPPGLTPVDVHMNGLHSECKKVTSVLNGHVKPTNMKYGTISSSSLGDKVLNTNLAEASRQSNNHSSAEEVNSKTDSEGCNDAFVEVGMPRSPSHSANTKDLKQMLNSTKAPCPTRQTVKLLHGTKNSHLHTAERLLSDSEMSPTEGPMTDKKAPGSERAAERAAAQHNCEMARFTSQSAYGNMQAYDYEQKKLLATKAMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVPYKPTMSTTYENSPMSLSRSNSREQLGNGSDSDNWRERNGIDSSHNDYSSSIGSPKRKQNKSEHYLSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDIFQQQEIDLQTFLTLTDQDLKELGITTFGARRKMLLAISELNKNRRKLFEPTNIRSSFLEGGASGRLPRQYHTDIASVSGRW
The following text describes a protein:
Function:
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral membrane protein.
Sequence:
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELSSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGDYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLADPDGALAKRLLLQLEATKSSKGSSGGKATAGAPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGACLMETVELLQAKVSALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQNKVHQLYETIQRWSPVASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMMASSLKDNTALLTQVQTTMRENLATVEGNFASIDARMKRLGK
The following text describes a protein:
Function:
Plays a central role in regulating the genetic system of this fungus. Has a 3'-->5' exonuclease activity.
Subcellular Localization:
Nucleus.
Sequence:
MPAEGACDAASLMTLTATLSDVTGLANLLKSVAIQTHAVVIASSSGLEIITELNRTLQAHAYLYSHMFDSYRFENAQDDVRGSTSLQARSRPKKRSKLTSKHAETADSQSSAASSDHESGQSQAHTKKRFRANSHSYAQEADRVHDEPDSVSFEVNLQTWISCLNIFGGVGPSRPHSSSSGLPGFRPEQGSAEAPPGGRGYQRTRYGVADAYGAERGTSVERGFDRNPFSSSAKATRMKLSYQGHGNPLVLELEQDANVLTRVSMSTYEPSFLTDMVFEPQNMVAQVIVASELMQSAFTEIDASCKKLSILITSPHSLSTYDGDQRTEAPAPTNRNTSASMLKFRAISDTGSSEMEFPASLTSSDPTGVIEKFVALPGSSEQWYDFTLLSRTMSVLRSSIKTSLRMDEAGLISFQFMMPKYRRAAAAGAPLTNAAAGQAAHEDEQDAFCEFLCCPLDTSTLIV
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MVDNNKTQMEGLSSGLKLEAMLEHLHQQQQERLHSEQQQRRLREAHFFYTQQLAAQQAILAAARASGAALINTHASLLSSSSVDSEREDEEERGRDSAEDEDEDDEDSEEDELDFLRKQSLALQQRDTAVSGSRSGPGAPGATVRVKEEPEEEPSPADRPSDTSPNGPADWSYEEPFKANGAVSWSDDTDAARSRGEASRDFAKLYELDSDPQRKEFLDDLFTFMQKRGTPVNRIPIMAKQVLDLYRLYRLVTEKGGLVEVINKKIWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECERKALSSPNELQAAIDSNRREGRRPSYSNTLFHLSPPPGSAPHLLTSPTMQLSALSALNGFQPTAAALKKRLEDMSPSVFAGRSLPLTPQQAVCFARAATLEQLREKLESEAPERKLLRLSEEQQRVLQHSTHTNNNTINAAAAREERQDLSLSISSGGSASISVSVEVNGIIYSGNLFAQKSVSAAPAGPSGLFTFSSSAPSQSPASCSSKGRSSVEASTSGSP
The following text describes a protein:
Function:
With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.
Sequence:
MEFCVHGPRANWKGFLRLSLVTCPVALYPATSESEKISFNQLNRQTGHRIKYIKVDQDTGDEVPNEDIVKGYELEKGQFIEVTKEELEEIALESTRTIEIDEFVDKSEIDPRYLIRPYYLRPDGKVGHDAFAVIRETIREMNKVAIGRVVLTNREHIIALEPMDKGLVGTLLRYPYEVRSEQEYFDEIQDVKVTKDMLDLARHIVNQKAGTFDPEKFEDHYESALVELINQKRAGKLIRPKERPKGENVVDLMEALRQSVGREKATEPANAPKKSAKKPRKAASGQKEMLMPIAGKKQAKEAGAKKQPARSQRRSAWLGPNVC
The following text describes a protein:
Function:
Plays a role in oxygen metabolism in the mitochondria by regulating the levels of reactive oxygen species (ROS) thereby conferring resistance to oxidative stress. Involved in resistance to P.aeruginosa PA14 infection. Regulates lifespan.
Subcellular Localization:
Mitochondrion.
Sequence:
MIEKMILRRFFSTKSSTMRAWVSENGSGVELKEVPLPVINKPGQVLLKVKAASVNPIDVDMSQGYGREFLGTWKKIESCDAAASRFPLIPGRDCTAVVESVGGDVHNLAPGDEVMAVVPVILPGTHAEFVVTDSKYCSKKPSNLSFVSAAALPYVASTAYSAFTIARVSQRNAKQQRVLIHGGAGGVGSMAIQLLKAWGCEKIVATCAKGSFDIVKQLGAIPVDYTSDQATQELIEHAPFEVILDTVDSQLAKWSDNVMGVWRNCVHVSIVSPLMREMDKNGVPLGLVTTAMKHFERSFQSHLRGRWFSYAFFRPSSDLMSQLSRFAEDGKIVPVVEQVMGFEELEKAYEKVSQLNGRGKTVIKYD
The following text describes a protein:
Function:
Catalyzes a disproportionation reaction in which single or multiple glucose units from oligosaccharides are transferred to the 4-hydroxyl group of acceptor sugars. Glucose, maltose and maltotriose can act as acceptor, whereas of the three only maltotriose can act as donor.
Subcellular Localization:
Cytoplasm.
Sequence:
MHISSLPGKYGIGTFGRSAYEFCDFLEKAGQKYWQILPLGQTSYGDSPYQSFSAFAGNPYFIDLDILNEKNLLDKDDYEEKNFGDNKEMINYGLIFNEKMKVLRKAYMNFNSKDDESFAKFIEDEKKWLDDYSLFMALKYKFNFISWNSWNKDIKLRKNEEIEKYKDELKEDVNYWKFLQYEFFSQWKNLKDYANKKNIKIIGDIPIYIAQDSSDVWSNPDIFLLNKETLEPLKVSGCPPDAFSETGQLWGNPIYDWGYLEKTNFEWWVDRIKSSLKLYDILRIDHFRGFEAYWSVDYGEKTAQNGKWIKGPEMKLFNVIKEKIGDIEIIAEDLGYLTEETLEFKKRTGFPGMKIIQFAFGGDSSNPYLPHNYEKNCVAYTGTHDNDTVRGWFEVTGSKEEKEKAVEYFKLTEEEGYNWGVIRGVWSSVANTSIGVMQDFLNLGNEARINKPSTLASNWSWRAKDNVFTNELANKIYRLTRIYGRCE