lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar-associated type III secretion (T3S) system. Plays a role in hindering to flip the flagellar T3S specificity switch from the rod and hook-type substrates to filament-type substrates prior to hook-basal body (HBB) completion possibly by preventing interaction of FliK with FlhB (By similarity).
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MIQPISGPPPGQPPGQGDNLPSGTGNQPLSSQQRTSLESLMTKVTSLTQQQRAELWAGIRHDIGLSGDSPLLSRHFPAAEHNLAQRLLAAQKSHSARQLLAQLGEYLRLGNNRQAVTDYIRHNFGQTPLNQLSPEQLKTILTLLQEGKMVIPQPQQREATDRPLLPAEHNALKQLVTKLAAATGEPSKQIWQSMLELSGVKDGELIPAKLFNHLVTWLQARQTLSQQNTPTLESLQMTLKQPLDASELAALSAYIQQKYGLSAQSSLSSAQAEDILNQLYQRRVKGIDPRVMQPLLNPFPPMMDTLQNMATRPALWILLVAIILMLVWLVR
The following text describes a protein:
Function:
Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.
Subcellular Localization:
Periplasm.
Sequence:
MNVLRPALLTLACMLASPVMSDDLPSLGDASSSIVSPEQEFQLGRAWLSMLRNQVDAISDPQLKDFVESSVYRLAETSDLQDHRLAFILIRDAQINAFAAPGGVIGVNGGLLLNAQTEGEYAAVLAHELGHLIQRHFARGIEAQQRMQLPVMAAMLAGIVAAAAGAGDAGIAAIAGTQAAAIQNQLRFSRQNEQEADRVGVTNMVRAGYDPRSMPNMFERLARQYRYDGKPPEFLLTHPVTESRIADTRNRAEQYPQGGKEDSLRYQQMRARTQLLFEETPGMAGKRFRAMLNDNPKLDAARYGLAISQTRIGQLNDARDNLRQLLAKAPNDVAYNLAQVELDITANRLPDADQRLKKMLAQFPSSYPLKQVRADLMLKMGKPQESEKILDDLSKARPLDPDVWNRLAEVRSLTNNAIGVHQARAEYLSLTGDYQAAIEQLDFAKRRAGGNFQLAARLDARQQEIRQQEKMVKEMFR
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MANYLAKEALHHARESKRSGQFYFLMILFVRGITSNYPNPDMGCVATIRKSSSKHFHYHQMWIRGFHASQSIHYPPFPVPTSRQTTFLNPRVHKGPTPISLRVATYLPPYPKRIHVFRFLCLSHSVQLAALSVEKDGGDSRGQQDLSPRVLLMLPGCQTARIAEHVSVSGAMLAAVVEGINSGMVTKEEGIELELGLSIGGSYRRENGNVLKSGTSMDMGSSEKSGTCIRSSSSPCFGEDAMQELDPKTKREMHALRRKEAKRRKELKKGFCKGYNLNSSQLNNHGEIKINKNIGMWLKAKDFQVSNSDGPECKKIKIEATGSDQNDTSKVNLNLSMDHDDPNGNNNNSAYLPLHYGLPANGFVYPCGNMNVMPCWFTAIAEEGNAVPVFSYGFVPFQAGSNPGHHFGNGYESEHNCSLDGGGNRKVGSNGSPLGTSSTGSDHRSSSHEGDGSSLSRSHSSPSVPEQSQLSGLKANKTRGHSELGATSYLAEPGSVNESTNQVDKLIQSNSNQPSSVAPKEEAKIETEPDPAENHVTTPENPIFIPLMEAKGNMGKPPKPQSENHITPSLPYMPCVSTTGNGPNGKTINGFLYRYTKTEVSIICVCHGSSFSPAEFVQHAGGTDVSHPLRHITVIPSAI
The following text describes a protein:
Function:
Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSSVGPLEDEAAGTELGGSPADPATLTEIDPSAIQVRKTRTVVKLDCERLVSKKGLPYLLKNAPKHARISKRRDTYGNLCHVLQFYQLWAHELYPKAKFKDFVALCDRLGKTDRQLRAYRMQLIREELGLAAEGLDPPPQPLREHTGAGGSQPAGSVAQDTNTNADLSDDDLLYTTSRAAAASSTANPVPRSETPAALAGVDEAELLAQLAEMQRAAEEDVHESEDDEQLALMREMDEFM
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKYWQAILFFLFGIAFANNLNIPWKACPNYKTYSGRRHYPATGPLRLPFQRPATSCRTFHSKSVEQTIEDVKEQLEDEDLARLFENCMPNTLDTTIRWHAADSHNPQTLVITGDIPAEWIRDSANQLLPYLPLAKSDSPLATLILGAIQTQAEMLIQFPYCNAFQPPKQSFLSGNDNGQSDRVTPAYDPAVVFECKYELDSLASFLKLSYTYWLYTKDQSIFTVKWLAAVERIIQVLEEQSSPSFDEKTGLPKDPVYTFLRNTDSGTETLGLAGRGFPLNANASLIRSAFRPSDDACVLQYFIPANAMMVVELSHLNQMLQASGHADIARTALVWANKIQKGIDQHGIVDHPKFGKVYAYEVDGYGSILFMDDANVPSLLSLPYLGFVERDDPVYVNTRKMILSSEGNPYYLKGKVISGIGGPHIGLRNVWPMSLIVQALTSDDDDEIMSLLDVLKHSTAGLGLMHESVDVSSFKSFTRPWFSWANSLFAELILDLLERKPHLLKKNAS
The following text describes a protein:
Function:
Highly potent vasoconstrictor.
Subcellular Localization:
Secreted.
Sequence:
KDCLGKRSPSPSGLGVQGGHTLHFHFYGESSGVGSPGPESETSYQLSAVDEDANLNLKELDRASLLQALSELLDTQKDDGLRKTDLGSSIYNPIGSTKETLDGKDPATSLLSRLLTKTRKQSKKHVPSSNCFWKYCV
The following text describes a protein:
Function:
Transporter required for vacuolar uptake of basic amino acids.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MGKKDRQRKKLREFAKLKNRQRNLRKSVQTLKNEVQREAKVPRTSNQIALGNDKIEEINENSPLLSAPSKQEEVSIPKAVDIDTIDAQPLHEGPKIDDSPQDEVNSIKGKPADKANEDDLKPPSQHEACGNSALQSSITDFSDRSVSPLQSITSCNTPMSEHELPVSSSNSFERADDMPVVQADNQTSSSKSLHIVAPSPEVPVSGDEITSYGYGSIPQSIGDVENGLNPPYVENTSSDELVHDLTRRRIFSSCMCTYLFFIAMDSSIILVIASKIASEFHELWRLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGGYLSWSSAHFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKNDSRYSLSASMITFAMGVVIGPFMMNLFDSSHGSGWRNAFLIPVPFCLVNASIMLADMYSVKSTLYGRPTPTLWKRFKNTLLSPDLYEILTLTLFLLCFVQVTSLDLTGLKNNTMIQALLFSVIIVCGILFFLIETSDTYMNSVISMSLQGDKRLIWTMIGISFCFAALMCIIPFGTTYFIIVLNLSTLQLAERLSPFFFSIVLGYFSVSYFWKSKGQNFLLKFVLSGATLLLYVALMGVSLNLPVWKQYICLSLPFLGSSMILTLLSNLYHEYHEQRKSPISGSIVYCFGAVGGTVGISLGGYVFHKTLIKLMHEKVMPFSKQGYLKKDLLKIIKHATESSDWVHESAPKFVFQTLIECYLQACRNVFKLSTLFFTITVVAIFIFNRIHCRSQNCLSLS
The following text describes a protein:
Function:
Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEASLKRLYVGGIGSSVTDSELTDRFGKFGKVNDVDIISRKDEQGNPVKTFAYLNINISETDLKKCMSTLNKTKWKGGVLQIEIAKESFLHRLAQERQEAKDRSILKAEPKEELVQSLQQAGVKDFQMKAAVPGTEVPNHKNWVVSKFGRVLPILHLKDSNKKKITKYDPSKYCHNIKKLEDTSLEMTPISQLTWHLEGGDDDISRKRRGEFPATKSPSNKKPKMLKPLNTKEPNEKTKGNIAKKSILSVTKESPGTPRNAEVSGIKQEINMHVVSKKKWWDESDSEEEMRTILEREKNEVKVGPTLATDSNLEIVDNTFKLRYNTHWGHREESTSKGSQPDCSSKGKDDDEYDSADTDEIISVAKTVKNVKVGSEVKENALAIEKQFLLAQKQKSNHGSENKKSQKERPKESNSVNENDDLGSESSDSYSDEEYDSLMQNCQRVSLTLEDLTQLASAAKDTSEDETIEEEAESNEEREEVKTPAAAQRKKNGINPDDILASLLEDDDGSSDEQLKGKRKKEPPVKLPAFKRLGSLLVTAPEQVHEASLSSKSNFSDSGSDSGNQNDDLGSESSDSYSDEEYDSLMQNCHRLTLTLEDLTQLASAAKETSEDEAAEEEAESSKSNQHEDVKSSAATQRNKKSGTTPDEIVASLLEEDDSSSDEQPKRKRKKETPVKLPAFKGLGSLLGTAPKQELDASLNSKSDLLPSTSSTVKNKTCETDRCNTINTEVPKKTAAEKSVQDLELSKSQKKGKVEVKQSSSSESSSESSSDESSTSSSSSAIPAAHTMTQKSKSNEQVKTSAQNSEALKLQDNKKRLAAMEERRKEREQQKQAIKGALLKQDSQPSSKGKHIVFDSEADSEEDDKVTLSTNAMSKPTVNEQSKTTKLFESSDDESKEDDKGSDDADRFQIKSQYEGRSGEKLMQLQSRFGTDERFKMDSRFLDSNSEDEEEEETSQKTQADKEGDELSAEKKKNLNILQSLLNINVEQPPVNKQAAKAKKFKDLNTLQYDPTREDHAAFEAKSEEEEKKESKAQRKKKRLEAEKIPEVSAETYHEVAIDFKEVFGASKPDPTTGTAWDQEEEIEGLGEESSAETQQFSFLTEDKEEPSGFTFSFFDAGNESVSKDETYKIETIKPAKVAWQEDPRFQDSSSEGEDDDEPSTGKESKISMETKTPKSTMRFFFFVKDDERLKEGPKMFFQSSKLTELEEAWEQRRDYLLEECKKRHKDAKRKVKAKY
The following text describes a protein:
Function:
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MKVLAVDYGTKRVGLAIGDEELKIVSPKGTVSSKEAVKKIKEIVEKSRVGKVIVGLPLTPSGKEGQRAKLVKDFVEKLREELPNTEIILWDERWTTAEAMRRLEGLPPKKKKELKDVISAMIILEEYLNSV
The following text describes a protein:
Function:
Catalyzes the degradation of levan mainly into levanbiose (difructose). Is not active on sucrose.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYRAAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEGVAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKGKSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYTSGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFKADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGTDSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDTDLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPYDVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITVKHFDSIHE
The following text describes a protein:
Function:
Transcription factor that plays a pivotal role in hemopoietic and endothelial development.
Subcellular Localization:
Nucleus.
Sequence:
MMEKRQPELCPGSPDAESGPGKREDAAIISRQNGCKEDEESKREEGDKEGGGRFKGDEETDDVPLQNSSNGTSISIIINGVTKETASHNALDLKREVPVIELSRRDAIKAVEQRTESHLVPITELRRPPQLPLPPQQRDDARMVQLSPNAFPVPARAMLYNLAQPLAAINSLGGESEQYSMYPSNRVKRRPAPYEVELDEAKIVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYISFLSNLLEDQDGGRNVSSTTDGETGLMVGAHEVGPQGGPHQDRVVGLARDDIMETMSPGSSCGSLPDGDADGSPESFMEDQDSPPAPRTLTASRGPPLHLTTRDLRRNGRPLDGSSRR
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.
Subcellular Localization:
Nucleus.
Sequence:
MASGTRRKANDDSQSSSEGSSSTTPQFIPQVPFDFNLGSINEEVDDSNGLTGIASVPKDILTPLRDHYSLAEVARRHGISADRPTEIEAAFFPEVQMSRSFSDVFLMIRNTTLSIWLASATTECTAEDVIKHLTPPYNTEIHLVQNIVLFLSRFGMINIGFFFPKTELVNNMEKKFVVVIGAGAAGIAAATQLLTFGFDVAVVEASGLTGGRVRSLISKHGELIETGCDSLRNLDESVITTLLHQVPLNENIMSENTIVFSKGKYVPVARCHVINGLYANLKAGLAHASHGPEQRGENGLYISRQQAYENYFNMIERSTLLSYYNFAKEKVNLNAERKHLYEVLKTNRLTALLAEQKLKNTPPSDELLLKSLQIDIEKAIRQFDEACERFEICEERIADLEKNPRCKQSMHPNDFIHYNFLLGFEERLFGAQLEKVQFSCNVNELKLKSQVARVQEGLAQVLINVANERKVKIHHNQRVIEIDTGSSDAVILKLRKPDGSVGILNADYVVSTLPIGVLKKTIIGDERAPVFRPPLPKSKFAAIRSLGNGLINKIVFVFETRFWPESINQFAIVPDKISERAAMFTWSSLPESRTLTTHYVGENRFHDTPVTELITKALEMLKTVFKDCPSPIDAYVTNWHTDELAFGTGTFMSLRTEPQHFDALKEPLKTRDGKPRVFFAGEHTSALEHGTLDGAFNSGLRAAADLANTCIEIPFINRSRDLIFPPYPRARYSNEGD
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MFVRIDCVIAKKIKIVTSKDQHLYLIDNASKPKFQIDLSIAIFNIHINKRNKVIPQGKENLCFELFYDKVYTFCCPSQIEFDEWMSTLPLLTKVYGTFKYPLGCAVSKSAWRYPIPIYRAIEYLQKNKGAESEGIFRTSASYKIVGRVKSILDGDQDIVIEEFKECACAAAIIKEYLRELPDPLIPFQYYNEFVILGRLKDGVKEKEAKKLINKIPDVNKNTLWYLCYFCQEVVKNVEKTQMTAYNLGTCLGPTVCRAPPHEAMKEMENTKLVIEGFATLINSYEEIFKDIEEINLRAGITPPNYPAVVPHPSAPYEKVTEEIQKVVVERQKRINAGKPRQTIFSHKSIKSEVTDGTSLVKEQVQKVMSQNNGLTRPTTEAPKPSYLPPKPNRLQHNSNELIGGNSASGVLTAIIDKEEDKRKENPNKGKSQEHRTTNNTKDVIEQTEQENNNNNREEIEEKVPTLPPPRRKTSCFRESTGELISKVIEQEKEIEELKNIIQKLEKRISKEEEMIETLIQYNNQYYQEYGGYEEGYYEGQE
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MRSSEVSSEGDVELSLGLTLGGRNNGNKKYSNSQPLMANVVVSTDFSGIFCGEDFYSASRKRQMEAKKDHIESQRMLKKRQKLDDHRHHHRHHQAETTPNSNPNLKINLIPNHNPNSNVTVNMIPNPSATSTSANVSADESDQATVLPPYNHFPVMPMQYSYPYANGFGFSYMVPWYMNVSSSGQDGAMSGRNMFQPVPTRSFHTFQGIAGKEVLQSGGEEGGCGGSINRSHSMTGSQGSSLSAVSEFQSLSQQQGGSSSSDTRGGCRGGDAGQANHDGTDEKSPPFQQHSSSNQIDVESSIKHTFATTTDDDEQAQKKKKKKSLMISPMTKMPCVSTIGDGPNGKKITGFLYRYNKTHNKTEVSIICVCHGSIFSPAEFIKHAGGTNVSHPLRHIVIVPS
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I.
Sequence:
MAVSLLVNSPFRLIGIKSWSKGCVGAVAKRCCSSSPVSTPPPPPSPLKTRAVVFLSKYFNDVEWLVERTSAFRSWMQKFSYYGSTLGLYGDNMIATFYILRLGGSVRFAGHSEWFRQDSRGRISKNMLKMVELPVDGVDASGTLIDYDGLDYLVSQSGLRTLSLSGCPKVDGWFLSRLYVFRDSLEELNLSGCPNVTEGALASLHHLRNLRRLELSLPASSNPGLVRILLEEVLPDCHVAGIEYNQGLRHTDPQGTETDTERDTASHRDALTHRDTSTH
The following text describes a protein:
Function:
Couples activated G protein to adenylyl cyclase signal transduction from surface cAMP receptor. Pianissimo a cytosolic regulator and CRAC, are both essential for activation of the enzyme adenylyl cyclase. Pianissimo and CRAC do not function redundantly. Both proteins are integral components of the adenylyl cyclase activation pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MGKTERKKELLELFEYEKIKGDVSYSSIMKKAGGNGKGFLDRYFALHRNYILYYKLGKSSLKPDDKQEPQGYINLMDCNPDDTKEIAPLMFQISHKHRTYIVKAKDESSMKQFLTLLIARIRSLEKIDIDKLGCTVVVLTKVKKFREVLTNPLILPDRVSPEMAEEWVKQMKNYNASFNLADPFIKQVEQISEFCRGEVKEYIDWFGGPEGPRLAMIRCEETVLSNWVEYINKTSSEITTYQDNRFFREDFKDIAVHLKNMTTFIDCYNDYMIHCRKYNNNKPNTKFLEEKQTFKEYIEKFIPKVASCNDVSLNQFYDRSLIQSSDGIVTINTSGIKKTLINQSNIISITSTTTTTTTTTTTTCSMPNMSNLIHSLDHTNLNIIDLNHSKSQQQLHPPPSPHHQHLHHQIVSNSKDFNISVSSNNFNDGNSEFPNLDINCDFDLTSASNLSSPILSSEVPSNVVDPIGSGQGGGGSGGGGVTAVTEEAINEKWHFDCNTSMIFKPPSEDGRNEGSNMSTSSITSKMSLSLNGGFDMKWVYQCGYFKSKNMGSISWNGKHWCWSHPRTSYKIKYIWDPTKQSFLNIPFKSRVGATGGGSVPSSQSTNNLQSSTSSMSSLSSSSTSTTKRSHPTTLYPDYQFKDNLLTPIIIEGRHQPSLTLIDSPLTIPNACLLTIAMTQYIQDALIHLSLGPKVLSSK
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MTWEPNEIYTTESHIEQEGGENSDYVIMKKLDHFFRTFRTEDGTSSMRDQIQGCLHAPNPSVTVSLDAIMGYDNQLGHLIFNEPERCLELFEQAVTNYAKEITEDVPPIQILLTTNSEPTPLREIDSNLIKKLIVVPGLVISTTPVSSRATEIKAVCSGCGHILTISCKNSGFQLPRKCQRPRPKEGGPAVAGGSCPLDPYTILPDNSTFTDYQFIKIQEAPEDVPPGEMPRHISASVDRALSNNLIPGTRKLFVAILQMMKINDKVQKQVLRIVGIVDPIVEELNTKSVSELSAQFPNREAIIKAFAPEIYGMQDVKEAICCQLFSGVRKNLPDGMKIRGDINVLLLGDPSVAKSQLLKFAHSVTPIGVYTSGKGSSAAGLTATVVRAKGSGEFFLEGGAMVLADGGLVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITAVLNTRTAVLAAANPVSGRFDDLKTARDNVDFQTTILSRFDLIFVLRDVKDEARDRNIAEHVLKIHTGAGAEQTNNTQTGDLKKFIQHVRAHCNPSLGDAANNLLKSEYVQMRSQIDNTQSIPITVRQLEALIRVTESLAKMEQKDECKEEHVREAIRLFKVSTFNAASTGILAPEGPMTDEQRQEVNKVQDYINRRCPLSSRINESALIAELKRKFTDFAIVRVIQTMLYRGEFEYCNNRRSLKRARADEKDTD
The following text describes a protein:
Function:
Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity. Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGDAPSPEEKLHLITRNLQVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSLHFCAECNNLLYPEVDRTNHVLLYACRNCNYQQESRESLVYRNDLMSVTKEQPGIVDNLMKDPTLRRTHDLNCPNCGHSEAVLFQDQSKRIMNRMILFYVCCRCNHLFRDPAQPAPREGPGQVWNDRKKK
The following text describes a protein:
Function:
Activator of the kinase cdk-5 (By similarity). In several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles. In the ventral nerve cord, regulates the synaptic localization of the glutamate receptor, glr-1. In DA motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the polarized distribution of dense-core vesicles in DB motor neurons. May regulate these processes in association with cdk-5. May also play a role in GABAergic synaptic vesicle localization in the ventral nerve cord.
Subcellular Localization:
Cytoplasm. Cell projection, dendrite. Cell projection, axon. Note=Presynaptic localization in the axon and punctate localization in the dendrite.
Sequence:
MGANLTSPLPHHHRTQTTSVCNHLFSPGDGGPTFAPQRDSNTSSRSSSNAKESVLMQGWNWSKRNIQPVMSRRSLPKSGSSSEATSSKSSDSLVSFTRNVSTSTSSQYGKISISLDRNQNYKSVPRPSDTTTIIPNYYSLREEFRRGLQINTRQDLVNNNLASNDLSVIGSPKHVPRPRSVLRDDNANCDISPIAEQENVPSEASTSELLRGLGIFISNNCDVSDFDPAHLVTWLRSVDRSLLLQGWQDIAFINPANLVFIFLLVRDVLPDERHLIHTLEELHAWILSCLYVSYSYMGNEISYPLKPFLIGNDRNTFWNRCVAMVTSHSRQMLLLNSSSTFFSEVFTDLKHCSSSE
The following text describes a protein:
Function:
Probable transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNASENYFTMDPTENISQVLDQNRNNTNSLRTHPTVEEYYENMTAFLSLAIFIASLLTILNISIFATTVSRLRRHLDKPLLGPSIMMVGLYPIISVAALVTILVPYSWFICHTVMHVMFMVGGPVFRTLLFRYVGSEQNYVKETAGEAVQLNTPPCCCCCLCLPMVIPTKAKLCISRYMVWQMPFWQGSIMLVMNILYYRDIQLYRQVMFFFIPFIVCSIVLGAWSLQITVRMITKVRGDYQLRKKMFCLQLVVMLCKLQYLVLYDQLDGIKMGGEYPINHTVYKQTIINILILVEMVLVSMMVQSAYRTPVQVQIDEVNKEKEVTRI
The following text describes a protein:
Function:
Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to and inhibits the endogenous nicotinic acetylcholine receptors (nAChR) in the human rhabdomyosarcoma TE 671 cell line with an IC(50) of 266 mM. Not toxic to mice by intraperitoneal injection or to zebrafish by injection at the back dorsolateral region.
Subcellular Localization:
Secreted.
Sequence:
LKCYGIFRKIMTCPQGQNICEKFAYSPMHNGWMYSWGCTSNCHKGPLDKCCSTDLCNY
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTSPYQEDSDSNPKEENHPSSPYTQPQNQQNSQPQEYPQIQGYAPPPPGGMAQAPPPPPPPGWVPPPPPGWTPPPNYRMEDYIPRDYNPETYHYEQHYQEFPQYQQQPYNGEFYIPQPAMVTADGREIKPEPNQSTWYAVTYEETQYTTYWNSYESFEPQNYRENSTHEKKWNDLPYAIIFLIVLLINIIFGIVGMVKAGNFQKGFAYNRQGLAYGDDDSNSTYTYRSFDDWQTAMKKSVFSAIGYALLFNVLHGLYAIFLPAVYIKLAFVIPFILTLIVCVILTVITKIFYCMIPAGVTLLLTAICCCCCYNELPIAISVFKVATRVTLKYPGLILANIVQGIIIDVITIFVVFEIIGIFCIGWNYVAYIWVIFSAYWFYYTNEFVEVLITAGVAGTHYFLLDTEYMPKSPTLESTKRATTTSFGSACKGGLIVAIIELLEDAAEDSDNGCIKCIALCILCCLRYIIEIITHYGLIYCALYGIPFWDGCKRFIEAANTHAFRTIFDGVIIRYCMSYTILVFDILLFIVGYATSRRFTNDIFLNILCGIECIMFFSVIIQTICGNFCTICDTLFVCFGECPFRMKVIDNEFYELTWKELWK
The following text describes a protein:
Function:
Transcription factor, which in cooperation with EMX1, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combination with OTX1/2 to specify cell fates in the developing central nervous system. In the inner ear, it controls the distribution of GPR156 at hair cell boundaries, and regulates the organization of stereociliary bundles in opposite orientations across the line of polarity reversal (LPR).
Subcellular Localization:
Nucleus. Cell projection, axon. Note=Detected in axons within the olfactory mucosa and glomeruli in the olfactory bulb.
Sequence:
MFQPAPKRCFTIESLVAKDSPLPASRSEDPIRPAALSYANSSPINPFLNGFHSAAAAAAAGRGVYSNPDLVFAEAVSHPPNPAVPVHPVPPPHALAAHPLPSSHSPHPLFASQQRDPSTFYPWLIHRYRYLGHRFQGNDASPESFLLHNALARKPKRIRTAFSPSQLLRLEHAFEKNHYVVGAERKQLAHSLSLTETQVKVWFQNRRTKFKRQKLEEEGSDSQQKKKGTHHINRWRIATKQASPEEIDVTSDD
The following text describes a protein:
Function:
Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes. LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB. GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes. LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MMNFRQRMGWIGVGLYLLASVAAVYYIFEISQTYNRLALAQVEKTSGAQAKWPGDASSSSPSSTSWIVTLKTRLLLLPFWVWATIFLLPYLQVFLFLYSCTRADPKTVGYCILPICLAVLCNRHQTFTKASNQISRLQLIDT
The following text describes a protein:
Function:
Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEREPSASEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIEFHKEKVVCIAAGLRHALAATASGIVFQWGTGLAPCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAIIGGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQLPAHPALVQDSRVTYLSPDAIEDTESQEAMDKERNWEERQSETSTQSQSDWSRNGGL
The following text describes a protein:
Function:
Nuclear receptor transcription factor that binds to DNA enhancer elements to promote the transcription of genes required to maintain micronutrient homeostasis. Direct binding to its ligand zinc allows for nuclear accumulation and activation, which thereby induces the transcription of genes required to promote the storage and detoxification of excess dietary zinc. This in turn, allows for internal zinc levels to be detected and regulated.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes to the cytoplasm in the absence of excess zinc, but accumulates in the nucleus when zinc is in excess.
Sequence:
MQKVMNDPEDLGNCKICLQRADGIHFAVSSCRACAAFFRRTVILKLNYTCKEKGNCTVEKSLRNLCRSCRYTRCINEGMKIELVQLQRDSIGRKKSGASISIDPLFTPNVASSLSAIFKNEKEDVLSTSCTILSQMTSGYAMFLNIRRSTNTLVQSSVITPTFKMPKIELHASRFDSAKQVCKAEAHLVTDIVNSYFSPFNSLKFEDKVALFKNFFCYFSHTDRAYQSFKQFESDNLNDKILMPDGGFIKRTELGRFYENAEGVHTSAEDAAKIFQPALNYILDVIVDYMRRIHIIETEYLALLGFCLWDDAVPGLSKEAKSLAVQTQSKLLAELQNFYSSQNKDAVEITQRVGVLLLLVPKLTKCVIMLRENSVLAELFNYYEADVCCKNFKEDASVDLDCTSQCIVHTKND
The following text describes a protein:
Function:
Part of the outer membrane protein assembly complex (Bam), which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Nonessential member of the complex, which may orient the flexible periplasmic domain of BamA for interaction with other Bam components, chaperones and nascent outer membrane proteins. Efficient substrate folding and insertion into the outer membrane requires all 5 subunits. A lateral gate may open between the first and last strands of the BamA beta-barrel that allows substrate to insert into the outer membrane; comparison of the structures of complete and nearly complete Bam complexes show there is considerable movement of all 5 proteins.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MQLRKLLLPGLLSVTLLSGCSLFNSEEDVVKMSPLPTVENQFTPTTAWSTSVGSGIGNFYSNLHPALADNVVYAADRAGLVKALNADDGKEIWSVSLAEKDGWFSKEPALLSGGVTVSGGHVYIGSEKAQVYALNTSDGTVAWQTKVAGEALSRPVVSDGLVLIHTSNGQLQALNEADGAVKWTVNLDMPSLSLRGESAPTTAFGAAVVGGDNGRVSAVLMEQGQMIWQQRISQATGSTEIDRLSDVDTTPVVVNGVVFALAYNGNLTALDLRSGQIMWKRELGSVNDFIVDGNRIYLVDQNDRVMALTIDGGVTLWTQSDLLHRLLTSPVLYNGNLVVGDSEGYLHWINVEDGRFVAQQKVDSSGFQTEPVAADGKLLIQAKDGTVYSITR
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MPSLLPILSYDVPIQGEIPPLASNESSSIVFRGEQHCSSSSSVLKKHTTVCRELPEKKKKHVKAAQGGVKSHGEGSGGHSHPLAESVVSDSGDAGEGVAKAQAVAEAVKVMKKAVFAIQMALYNGLRSDFQLKAATCLLTQSEYADVVTERSNDKQCGFPLCPNSLKVEKARKGRYHISLREHKVYDLEETRAFCSTGCAVSSKTYAASLPSNHEGIMEHQKLEEIIACVRGLSLATTATTATTTVPAAASAGKMSASAQDSDGVVVRERTDCEPGDLEFQLSRSASIEGYVPRAKPQVQINDSSKPLKSAMKQSPRKNQRITWADEIPAAVAQPDVDDSFTFSTTVTVTSEGERLGAAQVVADALAQAANVSSLGEVEPCKAAATAGLEIVSPYEKVPETFEFDATKEAKEEEDEEEREDLISRSSWYSAPPKPYKAEVSPFGLLWMALDEWVSSGTLAHIYGRDDEEFRDVNGRVPVDGDGSSSPDILRTISSCVSRVLPDVVQALAIAEPLSVIERAVGRLLGTMHFSQALPAFTTKHWRMIAALFLDALSVHRLPGLGGQMTNNRALLRKLIIDSGMNDPEYESFKELLLPLGRLPAFASGGGG
The following text describes a protein:
Function:
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLQKPATRITSWSTEIIIITGGSHGIGAVLTDILANTKKVKKVVVLDKIPPTIQAENVCYFECDVSDSKAVEQVGSKIVNQVGNPTALINNAGIVSGKTMMDLTVSEIEQTIGVNLLGPFYTIKAFLPGFMDRNKGHIINIASVLGLSGTAQVSDYCASKFGVVGMTESLRQEIAHSNVYVTCVYPGLTTTGMFEGLSHKFPWLTPFMEPKRVAHAIVDALESGQSHDIKFPLYAHALPLLHILPIEISDLVKCFLGANDDMKEFKGSISASLYKSMTDVKLYPRPDRLQDPQ