lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.
Sequence:
QIPSTRHCSLFSDLTMEDAATSLATLRASDGGSVTVFKDSLSACSHYFDALFNGPLSMARQGEFLIPGVTRADLASIARYAHTRVADIDADNVESLIVASDQLLVDGLLRECCKFVGDHLDAPNCVSVLEMTRFFGLEELYNQAHRFLLDNFERVHAAGLDFHRLSIASMVNLLCCDELKVSKEELVWEASVSWIEADVTERKQYLVDLLPHIRFCLMKKSYVKRKVLRNPLVTKDALCKTIVQRYSKIQNFDKDACILSPIFNLFTQRVPAEIMFVYGGIHRGYKSNTWEIYDHKTNDPFCYCFDAVKMSWSAIKPMAQLRAFFGIAVLDKCVYCIGGSPNGVVTLDTAEEYDTVKESWRFIGRMNHPRLGASAASCNGRVYIVGGMSTQKLIRSTEAYDPETNTWTMVAPMKTERLFHGLVAYRDKIYVIGGLSRKSSVCEVYDPSSGKWSRGSKTKTFTDKVVAVVLDDRIFAIGEANQKDYKRCLEYFTAGDKKW
The following text describes a protein:
Function:
Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MTQAEKGEVAAAASSSSSAAAAAENGKDKERDKEKEQRGGGGGGSKRPIVPAAVPESLQEQIQSNFIIVIHPGSTTLRIGRATDTLPISIPHVIARRHKQAGQSIYKDSWLLREGLSKPESTEQRQNGLKMVDQAIWSKKMSNGARRIPVSPDQARSYNRQMRPAILDHSSGTKWTNTGHHPEYVVGEEALYVNPGDCYNIHWPIRRGQLNLHSGPGGSLTAVLADLEVIWSHTIQKYLEIPLKDLKYYRCILLIPDIYNKQHVKEIVNMILMKMGFSGIVVHQESVCATFGSGLGSACIVDVGDQKTSICCVEDGVSHRNTRLCLAYGGSDVSRCFYWLLQRAGFPYRDCHLSKRTDCLLLQQLKETFCHLDQDLSGLKDHEFQVRHPDSPALLYQLRLGDEKLQAPMALFYPATFGIVGQKMTSLQQRSQGDPEDPHDEHYLLATQSKQEQSAKATADRKSKPGGFEGDMRGQSANAAENLYPPEVELGTSHGECILGGNDSEEPLTAHMSRKSAVSQFEGKALGLDKAILHSIDCCASDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRRVVENVEVITRPKDMDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGVRMLRERAAFVW
The following text describes a protein:
Function:
Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MEIAVFGGGAWGRALAFAFGEKNEVKIISRRDLNEPLKKLNDALISKGSAPIEQVDLQRGLKATLYVIAISVQHLREWFQNASLPKNAKVLIASKGIEVLNKAFVSEIAKDFIDPNSLCFLAGPSFAAEIIQGLPCALVIHSNNQALALEFANKTPSFIRAYAQQDIIGGEIAGAYKNVIAIAGGVCDGLKLGNSAKASLLSRGLVEMQRFGAFFGGKTETFLGLSGAGDLFLTANSILSRNYRVGLGLAQNKPLEVVLEELGEVAEGVKTTNAIVEIARKYGIYTPIASELALLLKGKSVLESMNDLIRRA
The following text describes a protein:
Function:
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MASSDKDVEEQLLEAGNKIVEPPTSVEELLPLLDKIESLLAKVEQSPSISMQIALTPSLKALVSDQLLRHSNIDVKVSVAACISEITRITAPDAPYSDDQMKEVFHLIVSSFEDLSDKSSRSYAKRASILETVAKVRSCVVMLDLECDGLIIEMFQHFLKTIRDYHPENVFSSMETIMSLVLEESEDMAVGLLSPILESVKKDNEEILPIARKLGERVLNNCSTKLKPYLVQAVKTLGISFDDYSDVVASICKHLSGALEPSNLHDAGENVVEEKPTEVATPERVDTGMEKHHDSVKSNGVAQGGEDGSVSTLENKKEEHGEECKEVKSPKSPEPANLGSEKASNVKERSEKSSRKKGKKSNQSSKSTEISHVNSQKGSESQPERESHSEHPGSPREDQSAENLPLENEADAKPSSPKAMEIESANVASPSLRESVPDRCNNKSGQGNKIGQAKKKGNSVKEGVASSAEVSKKSSDGMDDSGAKLDSDAEEKVPAGVSDDAKAAAEDAGERESDTTSDFETKTLKQSVRKGDGTSKSGGSSLKQSEVKRKKGSTKSISGKNVKRLSGDDDKKETTPVLKPASKNTKDEKIVDKTPTTVSKRKRTPVKEKESGTGTGGTKGFDESLVGSKIKVWWPKDRMFYEGVVESFDRGKKKHKVLYTDGDEEILNLKKEKWQYIDDASESEQEETTDLVRSESAVETPQKKKAKVNANESAKRGKMDASPKKGGVTSSSKSKGAATKTDRSSGSKVESKSKENTPKVGRHTAVTGSKSKDQGTPKTGSKLGSTGPKIAGKSKNDDAESNKTSKSKDDETSTPVAVAKSNKQDVSKTGKSKQETPKTPVSKGKSTKTGDKSNNTNLSTKVKFTSSKAKEKESGDVKHSSTSGKTMENSKGKSLNSSNDQGSEYKSGKKRRRESKG
The following text describes a protein:
Function:
Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.
Miscellaneous:
MISCELLANEOUS: Present with 319 molecules/cell in log phase SD medium.
Subcellular Localization:
Chromosome, telomere.
Sequence:
MDTLEEPECPPHKNRIFVSSSKDFEGYPSKAIVPVQFVALLTSIHLTETKCLLGFSNFERRGDQSQEDQYLIKLKFKDRGSERLARITISLLCQYFDIELPDLDSDSGASPTVILRDIHLERLCFSSCKALYVSKHGNYTLFLEDIKPLDLVSVISTISTKSTNSSKHSSSELISECDLNNSLVDIFNNLIEMNRDEKNRFKFVKLIHYDIELKKFVQDQQKVLSQKSKAAAINPFFVPNRLGIPYIESQNEFNSQLMTLNVDEPTTDISNMGEEMHDSADPIEDSDSSTTSSTGKYFSSKSYIQSQTPERKTSVPNNWHDDDSGSKRKRKLSFHSPNASSIRKAISYEQLSLASVGSVERLEGKIVGMNPPQFASINEFKYCTLKLYFTQLLPNVPDKVLVPGVNCIEIVIPTRERICELFGVLNCQSDKISDILLLEKPDRISVEVERILWDNDKTASPGMAVWSLKNISTDTQAQAQVQVPAQSSASIDPSRTRMSKMARKDPTIEFCQLGLDTFETKYITMFGMLVSCSFDKPAFISFVFSDFTKNDIVQNYLYDRYLIDYENKLELNEGFKAIMYKNQFETFDSKLRKIFNNGLRDLQNGRDENLSQYGIVCKMNIKVKMYNGKLNAIVRECEPVPHSQISSIASPSQCEHLRLFYQRAFKRIGESAISRYFEEYRRFFPIHRNGSHLAKLRFDEVKHEPKKSPTTPALAEHIPDLNADVSSFDVKFTDISSLLDSSARLPRPQQTHKSNTLYSCEGRIIAIEYHASDLCFHITNELPLLQTRGLAPERVLQLHIITSKNFAYFFNRSSAYLQRQPLEEKYTQLAQFLGHSFKFNITSSLTLFPDTTVALQIWCPIECTFRELQQQLAHPKVAAAPDSGSLDCAINATVNPLRLLAAQNGVTVKKEEDNDDDAGAVPTS
The following text describes a protein:
Function:
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MELSELLYNKSEYIETASGNKVSRQSVLCGSQNIVLNGKTIVMNDCIIRGDLANVRVGRHCVIKSRSVIRPPFKKFSKGVAFFPLHIGDHVFIEEDCVVNAAQIGSYVHIGKNCVIGRRCVLKDCCKILDNTVLPPETVVPPFTMFAGCPGLFSGELPECTQDLMIDVTKNYYQKFLPLTQI
The following text describes a protein:
Function:
Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1. Modulates the activity of SCN2A/Nav1.2.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MPGARDQGAARARWLGIGLLGLFLLPVSLSLEVSVGKATTIYAVNGTEILLPCTFSSCFGFENLHFWWSYNSSDTYKILIDGTVKNEKSDPKVKLKDDDRITLEGSTKEKMNNISISLKNLEFSDTGKYTCHVKNPKENDFQHQATIFLQVVDKLEEVDNTVTLIILGVVGGVIGLLIFILLVKKFIAFIIKKTQEKKKECLVSSSGNDNTENGLPGSKAEEKAPTKV
The following text describes a protein:
Function:
Regulator of the GTPase activity of Ras, mainly RasG and RasB.
Sequence:
MDVDKQMLQWRKRAWLNSNQLYGELTDIIIKDTGFTSSFANLIDNSEVDSFSKNIVNIFTTANKTLPLIKDLIYNEFNTKVLAEGEGSILRGNSIVNKIEGAYVRLIGANYLRFVLSDLVTKVVLDSDLKLEIDPRKLNDYYEDKIEFEKKVAEVELRDNQKSLHNIAQQFLDRITDPSVVVEMPREIRAIADYTAESALRYAPESLAPLVGGFIMLRFFSPAIVTPEYSKLLSSEVAPSKRAKRNLVLLAKVLQNASNGVLFGGKEEFMTCMNDFIIGNKEKMSAYFNLICKDPLNQNNKWSDLEGVKSATTTTTILTPTNTTTSSNGSGGTTWAKPIVGGSKWLATTPSGNTPSPAISNASSAHNGKSNNTTNNNNNNNNNNNNNNNNNNNNNNNSNKTTTTATTISSNSWDVYIKNVQIQDLFDLHRIFDSYKEKIVNKIINTNNNNANNANNNNTNNINNKTAIRVIEILKELGPSPKTKTERKKKETDAAEEPTTSLQNGASMGSAFDECTHMLERSRFLFQGPNDKNDRSVFYLIVNRVKPEVFDNVNPLIAHIFKVMDICVNSPYTLVVDMSWAHISNDLKKAIFTHLPKLAEIFSRKYKKNIDKIFIVHPSAYTRAVIYFMSAFTSRKLKRKIHDIYNWKDLSQYIDIENIALPETSKDFITKSYRVVKVNSKGKRQERLIKFTSNSLLNIDPKTHRIQNEKRINEIDEITSRLGSIEINMKLSGESKKSGSILGTKIGFLSINNNNNNNNDDSNGNHDINESNSRKYICNHELERDHILQDIFETGFKMGLQSKSTKSLPTEYKVIKVNNVGKHQERIFKLTIDSLLNLDQQRIKSENSFAGIEEVILDPHDDDIVWLKFKSEPSRRKIICTVKGEGKLLLEVLTDAINKYQTTIDIQEGALKLDAEEGFL
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGFLNLFIVAVMPVLKIILITAIGLLLALDRMKLLGPEAKHHLNNIVFYVFSPALAASSLAETMTFKSFTTLWFMPVNILITFVLGSALAWLIIKITRTPKHLQGIVIGCCSAGNMGNLPLVMVPALCEEPRNPFGDPSVCSRNAKPYASLSLSIGVIFMWSYVYGIMRMYANKSIESSTTGVNSPRDTSETVSGSCTQAALPSSDCNTSHLPRTISSESSTRMSGLMKIMMRIKMISGKIDLKKMFAPAAIAAIVGFIIGAASPIRKLMIGNSAPLRVIDGCAHILGEATIPCVTLIMGANLLIGLKGSDVSRNVIIGIIAVRNIFLPLSGIGVVKAAHHFGLVGSDSLYQFVLMLQYAVPPAMSIGTMTQFFQLGQGETSVIMLWTYAVAAVTLTLWSTFFMWLLT
The following text describes a protein:
Function:
Degrades bioactive fatty acid amides, such as N-palmitoylethanolamine, to ethanolamine and free fatty acids.
Subcellular Localization:
Lysosome. Membrane; Peripheral membrane protein.
Sequence:
MLLLQIILLLLPVICSAGDRKPRHYEINLDEPPSQRWNQVIKDHLEYLPGVVEETKKYIPKPLQPFVWWAASKIDRYFTTEIQEELKGIASESGLPIGEIVGMNILYDVAAFDRRHIFGLGCTSIVAQNSAGQIIHGRNLDYDMTELLKNITIHVDFVRNGTIQYSGLTFALYNGVLTGQRPGEYSVSLNARYSGAYIDNILMEFYTKFKRPVSFFIRDVLENQATYTEAVDAFSRTHLFSPSYIIVAGIKKNEGVVISRNRWSAANVYPLNVDANQWFLVETNFDNWKKQGDDRRITAIQKLKELGRRNFDEKSMVEVLSTVPVRNNLTVFSTVMVPGLPDSADYFRQSTWILP
The following text describes a protein:
Function:
Plays an important role in deacetylating mercapturic acids in kidney proximal tubules.
Subcellular Localization:
Apical cell membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
MTEEKAEEKNKMASVFLPALGGVAVCGGTHGNELSGVYLVQEMERQRKERGDGVWPIPVTTVLSNPRAVKECRRYIDTDMNRCFSKAVLSTPITDSSPYEVRRAQELNNLLGVKGSDDVMDMICDLHNTTSNMGLTLIHYSASDWVTLHICKYLQTKITKVPVRVLVLDFPINDAYNLESVSKHGFTLEVGPQPQGVVRADIYVIMKEAVDLTIDWIHKFNSGTVFEGGDVEVFKFIKSVDYPRDPETRNLTAAVHPQLQDRDFCLLKRGDPLFLSFSGETVTCEEEEPLHPFFINEGAYYEKGIAFHLAKKWTLTVPSVQVQTTNSA
The following text describes a protein:
Function:
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane.
Sequence:
MTGQTSALWPTPRCGARLVHLNCARTSAGSAVVRVCRDKYSRCHQKSWVLRASQEPEGRSSEQPAPADAPETLTTRAAKLAAEIVASPIFYLVAGLLAIKLVASTGEDGAAIFIFAALPITALTALSKSSVGKQVQEQLEAKLPELQAEADKTRAAHAEARRQSKWYGPSRPRLPGPLGSAEHLIGAIAGDAGFDPLGLSKEQASFAKYQEAELLHARWAMLGVVGCLVPELLALRGVDLGEPVWWKVGASKLNSDLTLNWGGIEGFRIAGKQGIGLIAACQAVLMGGPEYARYVGIRSLEPVGVFLPGDQNYPGGGPFDPLNYAADADGFVEQAVKEVKNGRLAMLAMLGFFVQAAVTRVGPVQNVLDFVADPAHNNIFWNLAHLQL
The following text describes a protein:
Function:
Has a role in meiosis and sporulation.
Subcellular Localization:
Cytoplasm. Note=Localizes at the barrier septum and the cell tip.
Sequence:
MQDRFLKENTEIINLSSSIHPNRDSYLDSQSDPLNQNLYNIETENVKDLNIEDVDYYEKLQNFKIVDENIDPGLRTYSKRSVGVNNTFQNPCNRKIEGYIKEIERLSNSNKNLQAAVLQMAVSDTDDPRLKEEYKQTEKELLREISGNHKSKILKLEEELNDLKHSMKEMQLYMTKIIDKAMNNASLENLFSLDENNTKIHDK
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MKSDHLPKMADIWMSYVDRLRKKLIEHGVPLDYLDQLQPGLVTFIQKNRLQLSQMISTILPSNADIHDALLNTSDSDSVKNLFTESIVWLQWLMFEEEPDFALRKLTEVGQRSVCGAIWGKDDLAYRCRTCESDKTCAICVPCFKNGNHKNHDYSIMYTHGGCCDCGDVTAWKSEGFCSKHLGSEQIQPLSQEISHSLEPVLDMLFLYWKDWLLTMKSRNKMIHDDDDRNVLQVSSMLSIVVAKMLIKFCTCGDGLLSFISKKMVQTPDLLSLLVKGGNLLDNSTKDKIHELLLKLIGDPLFKYEFAMIFVTYYQYAIQEAVKAGNDSIINDKYSIISLFSVQLFTVPALALRLVKEINLLSIFMECLRIILSPYDREDGQSQGNKWHDLEATCLRVLADLCFSLNHDEVQQYIALERPDVFRTWLKILVLFQGIDSLKRQLHQEDHDNKYFLPFLCGDFLSKVNLFLVDEVFSMPKFSVARNDQTLGDLDIEVFDKGDYPRHAKVGKLSEETSACHISNVEYDYESLPPKMTWLISECLDVTEKVLELEISRTINVASHGSYNFKGCNFLNLRKKLSQKRVGRYSKLNHRKFTSSPVESIGAFSSGIEKINNDIYLREVKEPGTSSTEVETESPGLFSAVNWPDTSYDVTLEGISFHIPLHRFISLLLRKAMELCHSKTDAFEMYGSNHHYSGHVFFNQILGKYHPYGFSSSLMEHPLRLRVLCAQLHAGMWRRNGDALLWLPEFYRSTQWIEILPDVDLFLLQCCAVLAPDDLFVTRIQERFGLSDYLSLNLGAYDEYEAVMMQEMLTIIIQIIKERSCCGLSLSENLQRELIHKLAVGDATHSQLVKALPRFLSKAKQFKDILNIVAVYINPSSTKQGKYSLRTSYWKELDLYYPRWSSRDSQFVEERYLHICKVSPLDVQLPHWSKIFDPLSALSRMATSKSILFIIRSVCFYAIFTEKPSMCRAPDSVLITALHLLSLALDVCEKLRKVYTNQDGESHDMINASNKSCTGICYPSEIYPVLELSTKPIEAGIGNKSDMRKHHSLISLLVLLLNKYKKADSDADSTQKSIFTLIKCLLKKFSELNNVCMNALKQLAPDIVFEMPECNKSLSDAETSNVWKSKSREHQAAIMDKLKVQQSKFIDGLESSENNDLDLGHGNSNHEQVLDDLVPICSLCHDTNSKSPLAFLVHLQKSRLLSFNNVGSLTWEEIGKDVDRNSIASEEIADMSIDAPSSSQFSPLQTAFSHGLLQTGLNDLMDPVTGQLLHVRNSQLPFSFNNEDNDTLSSIEIIEKNIYLSIREDFDVQDFHFDELVDTPVHSLGAEGLKNVGDRITGLSRKVSSYHTVEDASPTSTIPSLFDCDGIHISSCRHVVHLDCHDRYISSLKQRRALFHIGELLCPVCRRFTNSLLPVFFYCFTPTKSQSLKKLEDSCSTSDISSSSLSMSDNNILLLSHALYLIWSMAKMVNQGKYSLCNFMKVFPGKINEANELALQPILQRLSEMYFPHEHGKVIASKVSHSLMLWDTLKYSLISTEIASRGKINICSEVLNSHLHILRGELQSSNGLTLANLLQVAHANRSMNHFHLLLRFRACQFFANSICAGILGEINITCVDWKQDNLFSILEGLDKESGFSAIQLWKFAADPVLSHDPFSSLMWILFCLPSPFMLSNESFQSLVHLFYIVCVLQALITCHVKCHHDKSSFSNNPLYEICKILEGDDFSKQYFTSNHINDSLCLKDMIREFTFPYLRNCALLRELIKSLSSPLFLDNTDATNVLLTPDMGKNILPCSIDNLQVNTQGITELENMFCICSLDAVLNDKNVHGLALKWCEHFLRAFKICKPGSVLYSTTVTPFRLIKLPYLYQDILERYFRRQCPNCGTEIKEPALCLLCGKLCSTLNFCCRENSSKTHSTICGAGVNVFLLIRRTNLLLQRSPRQSYWPSLYLDTFGEEDYMMKRGRPLYLSEKRYLNLSNMVASHGLDNNSEVLRQTTNIDADEFIR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Domain:
The RING-type zinc finger domain is essential for ubiquitin ligase activity; The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family.
Sequence:
MVGAAILESPGEGIGSNSILSQKRQLSSSDAAKRDAKKRSTMLMDLEILDCPICYEAFTIPIFQCDNGHLACSSCCPKLNNKCPACTSPVGHNRCRAMESVLESILIPCPNAKLGCKKNVSYGKELTHEKECMFSHCACPALDCNYTSSYKDLYTHYRITHMEINQINTFICDIPLSVRMNISKKILIRTEHLTNHLFAVQCFREPYGVYVTVSCIAPSSPELSQYSYALSYTVDGHTVIYQSPEVKRVLKLSFQTPQENFMLIPNSLLRGDVLEMRISVKKLNKE
The following text describes a protein:
Function:
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MAVPVCGGIWEWWGPVSFTSFDIRARELGQLGSAVRFEPLSFPVMHRGDPQARNTSRPAMLRLSNHLLANYKKGVRPVRDWRTPTTVSIDVIVYAILSVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSLPTDSIWVPDILINEFVDVGKSPNIPYVYVRHHGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLLRLPENVKFDRSVFMNQGEWELLGVLTQFQEFSIESSSSYAEMKFYVVIRRRPLFYAVSLLLPSIFLMVMDIVGFYLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERVALLLCLGEQSTSWRPPATSQATKTDDCSDVGNHCSHVGGPRDLEKTPRGRGSPPPPPREASLAVRGLLQELTSIRHFLEKREESREVARDWLRVGSVLDRLLFRIYLLAVLAYSVTLVTLWSIWQYS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MNVEFQKTLSNLEDKLNALITSLTTSPTASGAPAAALALLDADDSLTSAIETLRRHQENYARILKLRAEAESLEEKVKGIVRDVVGYEKEIRRICGDDEPSDSDADDVSDDDDLDSGGDRVQTKPGGLRNTKEIDYKLLLDFARRISKYNHQAAADAAANATQAAKGRGRSLQPGDQDMAMTGVNGGPGAEEGAEPVSSVTKEATSWLDESAKMTRQVYMIPYPMEDRIRMGLMGQIQLAAAEGRPGFNPDQEVERLIREAEGLGSTEPVVPASQPMGEERRHANEAAEAAAQAGAASSGTMAAPAPAPKPKATLDLDLYDPDDDEMM
The following text describes a protein:
Function:
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MANFPGFESLFASIESKITSNYDGLICFLHWNIVNRGFTCVGHGEDTSSSSKKSELLPAMWNSSQEEYAIRYVPQNSEDQYLLKCIVMGDTLLVNFMRLKDEKVSSLSLDVDQYINKEHLKDFDRVYRDKALLHQLINDDLIAPLNKSQTSTTTTTTTTRQRDEAQSSRQSTDQRQGRERETDPLRDPDPLRDIDPLRVPPRHPGQAGHPEWGQPRDPFAVGRDDLDPFGPGGAGMLMDPFRGGMPHRGIDPGIGMPGGRLPRGAVPPGARFDPIGPPRPGGPGGGPQGGFDGGPDPDHLPPPGYDDMFM
The following text describes a protein:
Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Sequence:
MLAITGFVFAASAIIWLWNYAKKPYSTLSKYKNIPVPKGGRYLFGHIFESAKHEHISRYELHLFSELGPTFGIVEFDTAVIITKDLDLIKEVYFNSSKTFSGRRKLFLRKWMRYSLVDQEGSEWKRIRNLLTPFFSTSKLKNNLSLVNCCCKTFIGHLEKMSYQQGPIDVLSLSAAFTLDFICSSAFGLQVDSQRDGDAGENGTLLTTLRKLTNLNFDDPLVFICFTFPFMSPILEFFGVSMFPSGFLEYFETFVDQIIRERLNSKDKQVNMHIYHIYSVGLTREEILAQTLIFVLAGYDTTSRTLTFALYSLAINPEVQEKVYKEIEDTIGEQESASNEKLSNLTYMDMFLNETMRCYPAAFRIDRRLTSNIQMSDGTALKKGTSIVVPIWAIHNDPQIYPDPEIFDPERFSPEESSKRNPLYHIPFGIGARNCIGMRMAQMVIKMALVDVLKNFVLLRIDETTVPLKMKKFTAFLQPESNIYLGLRRRTS
The following text describes a protein:
Function:
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Produced by alternative initiation at Met-54 of isoform 1. Alternative initiation has been proven in human.
Subcellular Localization:
[Isoform 1]: Mitochondrion matrix; [Isoform 2]: Cytoplasm.
Sequence:
MMLFGCRRSLWCALSFLGAAAGYRVGSAYLGTSVLQNQTPFELRNSKVVTQCTMKVELIPALTDNYMYLLIDEESKEAAIVDPVQPQKVVDAVKKHGVKLTTVLTTHHHWDHAGGNEKLVKMVSGLKVYGGDSRIGALTQKVSHLTTFQVGSLHVKCLYTPCHTSGHICYYVTKPNSTEPPAVFTGDTLFVAGCGKFFEGTPEEMYAALIEVLGRLPPETRVYCGHEYTINNLKFARHVEPCNDAIKQKLAWAKETYNSGEPTIPSTLAEEFTFNPFMRVREKSVQEHAGERDPISTMGAIRKEKDHFKVPKD
The following text describes a protein:
Function:
Plays a role in the sugar gustatory response.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNFHNTIRPILVIFLLFGQFPLYGVLTRKPLRWHFRWCSLQTVLSLGLIHVGLFLCFVEYDRLKAIGVNADNLIGPLFYLDVIIIMLLLLRVAYRWPTVVPKWEQIESLEVMQYNARQQNARSCRRIRAIALLLIVLGFAEHMLSIGKTVNARVYEARTCHWNYSNLPEYYALAHLRVLFPKSIIQLSLLYIFRALTMAWTVQDVLLIMISDSIAGYFKRINSRIQFYTTVQVVAREKFWSEIHSDYVMVCELLEHVMSICSPLLVVSCGTNLYLICYQLFHLVDRTDDFIIVTVFTYFSLFFIILRTFLTMHYCSAVHEVARKPLKLFRRVPTSNWCSELERFYSFIRKSSIAINAMGLFRLTKKTMLTMLGAVITYELVMLHFAQTTANQGIVRACSPEQFLFQPKMQITTN
The following text describes a protein:
Function:
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (By similarity). Receptor for THBS1 (By similarity). Interaction with THBS1 stimulates phosphorylation of SIRPA (By similarity). In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MEPARPAPGRLRPLLCLLLAASNAWTGTAGDGELQVIQPERSVSVAAGETATLHCTVTSLSPVGPIKWFKGTGPGREFIYSQKEAPFPRVTNVSDATKRNNMDFSIRISNITPADAGVYYCVKFRKEERGDMEFKSGPGTHLTVSAKPSPPVLSGPTVRATPEQTVNFTCTSHGFSPRNISLKWFKNGNELSASQTSVDPEDNNVSYSINSTTKVLLATGDVHSQVICEVAHVTLQGGPPLRGTANLSETIRVPPTLEITGSPSAGNQVNVTCQVNKFYPRHLQLTWLENGNMSRTEAASVFVENKDGTFNQTSWFLVNSSAHREAVVLTCQVEHDGQPAVSKNHTLEVSAPQKDQDTGQTPGPNDSNWTSIFIVVGVVCALLVALLIAALYLLRIRQNKAKGSTSSTRLHEPEKNTRETTQIQDNNDITYADLNLPKGKKSTPKANEPNNHTEYASIQARPPPVSEDTLTYADLDMVHLNRTPKQPAPKPEPSYSEYASVQVQRK
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk (Probable). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). Part of the complex F(0) domain (Probable). Confers tolerance to several abiotic stresses (e.g. salt, mannitol, drought, oxidative and cold stresses), probably by providing additional energy needed for cell homeostasis.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MRLFDPWPVFFKREWKRCWPFLTGFAVTGVLITKLTAGLTEEDAKNSKFVQQHRR
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MSQFPALEDFDDGLVTAPVDDSKNNTDFLEREKLALGEDAGQFETPEDKDALLNFENDSEAEQTRFEQNFPPIDAEMQASGTFSAPKAPYMGQAEVHPPEDESGDPEPVRKWKEDQMKRIQERDESSKKLRESNIEKARKAIDDFYENFNDKRDKVIAKSRKEQEKLLEENESKSTGTTSWERILKLIDLSDKPEAHGRSTERFRELLISLAKDSNAPGAAGTTVSSSS
The following text describes a protein:
Function:
Thiol-dependent isopeptidase that specifically mediate the processing of UFM1 precursors as well as the deconjugation of UFM1 from target proteins. Mainly responsible for the maturation of the UFM1 precursor, a prerequisite for conjugation reactions (By similarity).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MTAALPSTLELLKDVHLGLPVPCHDPARLALLSGHYLYYHYGCDGLDDRGWGCGYRTLQTLCSWPGGQSSGVPGLPALQGALEAMGDKPPGFRGSRNWIGCVEASLCLEHFGGPQGRLCHLPRGVGLRGEEERLYSHFTTGGGPVMVGGDADAQSKALLGICEGPGSEVYVLILDPHYWGTPKNRCELQAAGWVGWQKVKSVFDSNSFYNLCFTRNL
The following text describes a protein:
Function:
Plays a role in N-glycan mannosylphosphorylation and has partially redundant function with MNN4.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Domain:
The conserved DXD motif is essential for the function, which could be an indication that MNN14 has transferase activity.
Sequence:
MMLSLRRFSMYVLRSLRLHFKKIIITLLTIQLLFITIFVLGGRSSIIDGNWKSFMALFFKPLAYTNRNNNHASFDLRSKDNVAKLYEKMNFDTSGKWIDTYTLKNNLLTVKMGPEKGQVLDSVDELRYYDNDPRLVWSVLLDHLLESDSNEYAFSWYDWANFDSTNKLIALRHTNISCQFVCEGAFDKNVLEMVESEVQEPLFVTNRNKYDESLWYNRVRKVVDSNSVQQAIHDHCMNNDAYSNGTPFELPFIISEISERLRPEVYDLQAKNHLLYSNFTPLSLTVLDSDKDAYRINLKTTDSSKSNIVQTNLLQNYIKRHRNEMVNGDLIFNHTSMFEKFLHHGSTKKRKLDVEALDKTIYAGEYLELSPSDFQFNAKERIIELETRLRSEGLPSHDTHYLRSLKTSVNTSPALQQKYFAEASDITDATADGHHRDRRFFSIGHNLLNDPQEFEARLNSLIRNFQKFVKANGLISWLSHGTLYGYLYDGLKFPWDVDHDLQMPIKHLHYLSQYFNQSLILEDPREGNGRFLLDVGSAITVGVHGNGENNIDARFIDIDSGIYIDITGLSVSSDAAKQYMSKFVEEESSGESFSALIEDYKFDENDYFDEVDGREGLAKYTIHELMEWVNSHPDDFTDAEKNLVTKTYKKELAISRSDYAEKDLSPKQRYLVNEKYNLYNCRNQHFSSLNIISPLRNTMFSGVSAFVPNRPIATLNNEYKVPAKYGLLSFQGKVYLPEFRYWFSFADMKKFANLQLKEPKITRLESPLNDLKFSDISLLITNILKCGFHSVFASLFNSFDSTVYRLKELEIQYDPSLSEEEKSSLLKTLRRGMSKKIKSPEKDPIIYIYERKLWENVEKLLNASNIYNIASQVEKEKGKEFVERSQQVYERNFDGFRLPDGGNSKTVNDLNSKGLNLFGDNKKTSNNIFGSDQKY