lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cell adhesion molecule.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MWISSRFFVILLLLNLDNTCSEPFEAHLRGPGFVMEPPGRVEFSNSSGGWLDCSASGSPQPTVDWVHADGSAVTEIHGVRRVLRNGTLVLMPFAAAAYHQDVHNTIYRCIASNSVGRIVSRDVQVRAVVAQAYKVDVEVLSAARGCTAILRCVVPTFVKELVRVVSWVHEPAIYIYPSLQGDGKFHLLPTGELLIHNLQESDESQSFRCRSMHRLTRQVVVSSPTRLRINSHRGIISPSVVEHTAHVQVSQDEGAVLLCVAQGCPSPEYSWFTHNGAGPLPVLSGPRVRLLGPILAIEAVTGEDSGVYKCTAGNVGGEASAELRLTVATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSPVGMQNILWYKDGRQLPSSGRVEDTLVVPRVSRENRGMYQCVVRRPEGDTFQATAELQLGDAPPVLLYSFIEQTLQPGPAVSLKCSAAGNPTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQHAARLNIYGLPYIRLIPKVTAVSGETLNLKCPVAGYPIEEIHWERGGRELPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPSIEPFAFQEGLAEGMRTRTVCGVSRGDPPLKLIWLKDGDPLPDLLGANVTMLDQYSSLLSIPSLSATHSGEYTCVAKNPAAEIKYTALLQVKVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAVSGDKPINIVWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPPLPPSVLEAAMISSRSVNIKWQPKTLGTGDVTKYIVEFREADPLFVDQWQQIEVKDPPHFNAMIENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLPELRHGDIQGYNVGYKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQGYKLIFEPIIDDIQPSKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVPEAPADIKVVSSSSQSLYISWLPPNEPNGVITKYSLYTRVVNGREELNNEKRSLPSQQAYYEAKGLHPHMEYQFWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWRSTVTLPCTAVGKPKREWFKSDVALRQGGLHNSQLLDSGDLIISSLQLADGGNYSCQVDNGIGTDRLTHTLIVQVPPTAPVLYVTSATSSSILMHWKCGFTGNAPITGYTLFYRRANGNTDEMQLSRHASSHELKGLMCGSTYQIHLSAQNKVGTSPTSTILHVRTQGQSPGHPASTALLAPNSTSLLVRLHSWPDNGCPLLYFVLQYRAVTDDPDAEWVLVSNALKPQRRIVINNLQPSTLYQLRMEAHNVAGISQAEFNFVTLTKDGDPPPPEIMHRGRSGQTTVIFANINLLIPTIAAVSGMFCTIIMIIVCYRHMLKNAPPLAEQSQIQKESLENRANSEAAQRERYYATIHKVSMQNNDKIPETSEDISPYATFQLSEAGGNMSQPHHGGPANTLLHSFMYHERALAEGCSSPPPAAVLNPPTTTTHHHHHHQRPLKTIHNYYQTSPFHNISKNRRRHSRKTEPESEESESDQDQLTSSRTESSNQHEGKIKHSIIYHGAQSSTSSDLSPMSEQKSLPRRGRSRYHHQQYQFSTNTTPRHHNSNKMNNNTTSNTNTTATNTTATPSTSSNSNKILSPRGGNLKSISSTFKSQDSIQCHIPTLVKSPSISTQQQKQFHKQQLQNSSTNNSQHSSSNPNSSSLKQQQPLLITPKLHQLEANGQELLGLDGIGNSPLVACMPPSSQFRPIPHKSIMPAHEPPHHHNHSQQSHPHQQQQQQQHPGTLLNPSTAMLSSKFFTAPTLPK
The following text describes a protein:
Function:
Involved in protein export.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRDKKSLFKNVRVIIFILALLASVLLIHPGYNSEEGLNTNLNYGLDLEGGSWLQIKLQGALVQVDADPEMIVSQLVEPVIGAPIQVTDSNLEVSGVSSSDSYLTFTTSATVSASQLELLNLGSVSVDKLSQGTTQVTLTTSKETLIQAYLAQAFDAEVLPIDTEDGTVYEIRAEASEEEIEALMEKVGGTILKNEDGTSTYKEGVSTDTRDLTRDILNDKLNSLGLKDIPVRTVGEDYILIDFAGIDLATAKDIAEKPGKFEIRIQTTGNETQHVLYGDSIVSVGIPSYHDNQWHTPFTLDEEGARALQKVAIDTGATDYPESHYLNMYLDEEEIYGAPLSYSAASRLKETPIYSWEASTGTDEAAKTEAETLQIHLRAGALPVNVVLVGSGHVDPTLGEQFKTEAVMAGLLSLIAVAAVVFRRYRRSEILVPMVGTSVSEVIMILGVAAAIGWQLDLAAIAGIIAAIGTGIDHLVIITDEVLYEGRLPPTKVFVSRIGKAFAIIFGAAATTIIAMSPLVVMGFGALKGFAITTIIGVFIGVVIARPVYGVVIKELLEVDGNGSQESTAD
The following text describes a protein:
Function:
Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+).
Miscellaneous:
MISCELLANEOUS: Mrp-dependent antiport apparently occurs by a secondary, proton motive force-dependent mechanism, but the similarity of several Mrp proteins to membrane-embedded subunits of energy-coupled NADH dehydrogenase complexes raises the possibility that there is a capacity for electron transport that could provide a primary energy coupling option for Mrp functions.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVISGILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGEKRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESLKYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGMKGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMIWLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDMLIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGKFKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLYPAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE
The following text describes a protein:
Function:
Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).
Miscellaneous:
MISCELLANEOUS: Depletion of MAP1S by RNAi causes mitotic abnormalities that consist of failure to form a stable metaphase plate, premature sister chromatid separation, lagging chromosomes, and multipolar spindles.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Detected in filopodia-like protrusions and synapses (By similarity). Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1 isoform A. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules.
Domain:
The N-terminus of the heavy chain associates with the C-terminus of the light chain to form the heterodimer complex (By similarity). Its C-terminal part of the heavy chain interacts with ESR1.
Sequence:
MAAVAGSGAAAAPSSLLLVVGSEFGSPGLLTYVLEELERGIRSWDVDPGVCNLDEQLKVFVSRHSATFSSIVKGQRSLHHRGDNLETLVLLNPSDKSLYDELRNLLLDPASHKLLVLAGPCLEETGELLLQTGGFSPHHFLQVLKDREIRDILATTPPPVQPPILTITCPTFGDWAQLAPAVPGLQGALRLQLRLNPPAQLPNSEGLCEFLEYVAESLEPPSPFELLEPPTSGGFLRLGRPCCYIFPGGLGDAAFFAVNGFTVLVNGGSNPKSSFWKLVRHLDRVDAVLVTHPGADSLPGLNSLLRRKLAERSEVAAGGGSWDDRLRRLISPNLGVVFFNACEAASRLARGEDEAELALSLLAQLGITPLPLSRGPVPAKPTVLFEKMGVGRLDMYVLHPPSAGAERTLASVCALLVWHPAGPGEKVVRVLFPGCTPPACLLDGLVRLQHLRFLREPVVTPQDLEGPGRAESKESVGSRDSSKREGLLATHPRPGQERPGVARKEPARAEAPRKTEKEAKTPRELKKDPKPSVSRTQPREVRRAASSVPNLKKTNAQAAPKPRKAPSTSHSGFPPVANGPRSPPSLRCGEASPPSAACGSPASQLVATPSLELGPIPAGEEKALELPLAASSIPRPRTPSPESHRSPAEGSERLSLSPLRGGEAGPDASPTVTTPTVTTPSLPAEVGSPHSTEVDESLSVSFEQVLPPSAPTSEAGLSLPLRGPRARRSASPHDVDLCLVSPCEFEHRKAVPMAPAPASPGSSNDSSARSQERAGGLGAEETPPTSVSESLPTLSDSDPVPLAPGAADSDEDTEGFGVPRHDPLPDPLKVPPPLPDPSSICMVDPEMLPPKTARQTENVSRTRKPLARPNSRAAAPKATPVAAAKTKGLAGGDRASRPLSARSEPSEKGGRAPLSRKSSTPKTATRGPSGSASSRPGVSATPPKSPVYLDLAYLPSGSSAHLVDEEFFQRVRALCYVISGQDQRKEEGMRAVLDALLASKQHWDRDLQVTLIPTFDSVAMHTWYAETHARHQALGITVLGSNSMVSMQDDAFPACKVEF
The following text describes a protein:
Function:
Light-dependent serine/threonine protein kinase that specifically phosphorylates N-terminal threonine residues in psbA/D1, psbD/D2, psbC/CP43 and psbH, which are components of the core antenna complex of photosystem II. Phosphorylation of PSII core components facilitates the exchange of chlorophyll proteins between the grana and the stroma lamellae. Also involved in the phosphorylation of the calcium-sensing receptor (CaS).
Subcellular Localization:
Plastid, chloroplast thylakoid.
Sequence:
MASLLSPATPTATSAAFHSCSTAGFSTPTHISSQNSSLSLLSRRGCMMRCSFSPQDIPVDSLSHLPPFLDFQNSLATFSDTQKWGFFVSAGIVWFYLTARPGVLIGAIDAYLLAPLQLGLDTLIGRRLKRSDFLVTEKLGEGSFGVVYAGVLLPKNSTLVDDVRVSKARAKAMDFTGEFKQRVILKKVKVGVRGAEEFGEYEEWFNYRLSRAAPDTCAEFLGSFVADKTNTMFTKGGKWLVWRFEGDRDLADYMKDRSFPSNLESIMFGRVLQGVESVKRRALIIKQIMRQIITSLRKIHGTGIVHRDVKPANLVVTKKGQIKLIDFGAAADLRIGKNYIPERTLLDPDYCPPELYVLPEETPSPPPEPIAALLSPILWQLNSPDLFDMYSAGIVLLQMAVPTLRSTAGLKNFNLEIKSVEYDLNRWRERTRTRPDLSILDLDSGRGWDLVTKLISERGSLRRGRLSAAAALRHPYFLLGGDQAAAVLSKLSFSK
The following text describes a protein:
Function:
Involved in the spatial control of cell division, patterning and differentiation of Arabidopsis root epidermal cells. Could be part of a complex that negatively modulates GLABRA2 and CAPRICE expression via the maintenance of a repressor histone H3 epigenetics status of the GL2 and CPC promoters.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
Sequence:
MEPPKGDTVVKTEVPVKDPSLSVVDSKTKGVEDANTEIALSDEVEIETKGSDSTPVKAPSRTSSGSKKSVHWSPELVSGSQEPDQKAASSSSAGSNPYIARSPAETSDASLKDTMETVKGVLGRWGKRVAEAAKKTESLAGNTWQHLRTAPSFADAAMGRIAQSTKVFAEGGYEKIFRQTFETDPEEQLLNSFACYLSTSAGPVMGVLYISSAKLAYCSDNPLSYKNGDQTEWSYYKVVIPLHQLKAVNPSASIVNPAEKYIQVISVDNHEFWFMGFLNYDGAVTSLQDSLQAGALRSV
The following text describes a protein:
Function:
Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase PpsA for further chain extension. Catalyzes the adenylation of the long-chain fatty acids eicosanoate (C20) or docosanoate (C22), and potentially the very-long-chain fatty acid lignocerate (C24) (By similarity). Involved in the biosynthesis of phthiocerol dimycocerosate (DIM A) and phthiodiolone dimycocerosate (DIM B) (By similarity).
Sequence:
MPVTDRSIPSLLKEQADQRPNETAFTFLDYDLDPNGFAETLTWSQVYARACVVADELTMYGVPGDRVAILAPQGLEYIVAFLGALQAGFIGVPLSTPQYGVHDERVSAVLRDSQPVAILTTSAVVGDVTKYASSQDGQPAPSVIEVDLLDLDTPRPQQALPQPASGSAYLQYTSGSTRTPAGVIVSHENVIANVTQSLYGYFGGPDKFPADTTVVSWLPLFHDMGLILGICAPLVTGCTAVLLSPMSFLRRPARWMQLLASHPKCFSAAPNFAFELAVRRTTDEDLAGLDLGDVLGIVSGSERIHVATIKRFTERFAPFNLSPAAVRPSYGLAEATLYVAAPEPGTTPRTVRFDYESLTAGHARPCRADGSVGTELISYGSPDPSAVRIVNPETMIENPSGTVGEIWAHGEHVAMGYWQKPEQSDRTFNARIVNPAPGTPEGPWLRTGDLGVMSNGELFIMGRIKDLVIVDGRNHYPDDIEATIQEITGGRVAAIAVPDNITEQLVAIIELKRRGASAEEAMVKLRSVKREITSAISKSHSLRVADVVLVPPGSIPITTSGKIRRAACVERYRSDGFNRLDVTV
The following text describes a protein:
Function:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Sequence:
MSTGIYGGDEVGAVVLDIGSHTTRGGFAGEDMPKADFKTTVGVLADAEDITDGSTRKKYCIDTVNIKVPRNSMEMVNFVQDCMIEDWDTFEKVFEYFYKSYIKSSADQHPLLMSEAPWNISSKREKLTEIMFEKYSVPAFYLCKNPVLSAFASGRSTALILDSGASHTTAVPVYDGYVIQQAVTKTSLGGNFLIEECKNYFQHENIDIIPHFSVNETIEDFIQSVIQCSDNNYEEEIESMEATGPVHHEFPDGFNRKFGLERFRIAESLFDTNYIRSHSNPLVQSVSQIISSAIAKVDIDMRPSMYNGIIVVGSNSLLNGFSDRLMTDLANKLPASTKLKVNASQINVERRFSSWIGGSILASLGSFQQLWISKQEYEESGRNCVDKKCP
The following text describes a protein:
Function:
In asymmetrically dividing germline stem cells (GSCs), plays a critical role in ensuring centrosome duplication, which is essential for the production of centrosomes and centrioles in all downstream germ cells. Might recruit SAK for daughter centriole duplication.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=In male germline stem cells, gonialblasts and spermatogonia, localizes to the proximal end of the mother centrioles. Only in male germ stem cells (GSCs), localizes asymmetrically to the mother centrosomes and within it with higher levels at both mother and daughter centrioles. Colocalizes with SAK at the mother centrosome in GSCs.
Sequence:
MRAKRGAVGKVMMSGSRHNKLAESSRVPPLAREYISAMATDRELDRFMALSSTASSGASGSTHSCALGSVPPPGCASMEHESRPESGHRRRTKSSDHRSPDERGEAKEQLRELSVSPPPSKHKISQFTSPKSEVTKTKPNEYTIIPIVLASSPSFRSVAVTQTMSQSAEDIRTPTKSPQMQNKKTQTPESVLKSHKRLEWDPSADVGYCKRAMSMSNISTLERSVLEDCSWRQPTQQRPEANLDGVQPLLAEEPSPMLDKPTPPLACSTFVNRSERTKSLNSGMESSLSSNKGDPRKKCQRKSRRQDSEVSSCQTDCRSSSQKESTQGSSEAKDIRGNFTTEGTQCSYNRNDTEIDSIMEEEESIDRRKKDDLRISSRVQDPQISSRRPSVSSSRRESLSSYRRDDSRLNSPNSSRLGSEVSSRVESSRSSSRRESQTNSVYGSLSASSFDYHMHMAQEVEVLKHNQRRQQEMEVEPKKQLEKEQHQNDMQQGEPKGRELKDKNHHSGREQQEIQPLMRDQRKAEQRHEKDHQLEREQQGIQQLSKGQRKAKKREKEREQERQYTAAQFEKIRSNRRHVNKENQKPENPVVNPSTGVTASTSTTSLDVGSGSRPGGELDLGIDLLCSLVKSRSLSQGQKKKLVRDIARRISCLELTESSTSSRSLSSSSKEQLKVPTGSLQQVAATNTNQSNARSSSKAERIAPPVPAPRKRAAIGSSSPLPESVSYSGSTSGSGEVITQKTNIPNRNASTDADIEPLDLQDWLNPMTLSEIEFEERLKGGTDSERRRQLHWVKTEINRMQEFKNLLENISLPSKSQKKANTESATAAQIPSSMRCMGDQKERPDKEYLLRQEMSAEAESKEMENSETTTTPPPPVRIESVGVNVTNSDPSTLPAPPPTQPPPPPPHLNQRNLQNRKKMATPLLVSGSSTSGGGRSESVCSFVQQRQRQFREHYQNQQQQQFVLLQQQKLYQLQKQLNQQKDILIQRQQHCGQCAQCGHQRTCIHQQNCPRRQQEAEEQPDEREQYMQMQYAQAAGSAYATPHQSGSSGADKNEAIYYQVVNSQGVASYVQATMVSTETQNEASATGGAGGSAITRSTTTTTNSSSSMMCISSDMSVPMGMMNTCETTTTTTTHQYDDVACQRVRRGHKETTMNAESMQRQTLQVRPRAISYVIQFTPTGSSEVIEKPPSLQDQLQLARPEFCANAKQRKAILNEMQMIRNARRQELDNVLSQSTSMEALNRHLEQLPPPANTRVRLFTTREMKAITSKRCKNLPEVLAAQSRQEEEQRRRSNRLMRDVFNKRLKSRVASGQISLNHSMAIM
The following text describes a protein:
Function:
Transcriptional activator for the phage shock protein (psp) operon (pspABCDE) and pspG gene.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEYKDNLLGEANSFLEVLEQVSHLAPLDKPVLIIGERGTGKELIASRLHYLSSRWQGPFISLNCAALNENLLDSELFGHEAGAFTGAQKRHPGRFERADGGTLFLDELATAPMMVQEKLLRVIEYGELERVGGSQPLQVNVRLVCATNADLPAMVNEGTFRADLLDRLAFDVVQLPPLRERESDIMLMAEYFAIQMCREIKLPLFPGFTERARETLLNYRWPGNIRELKNVVERSVYRHGTSDYPLDDIIIDPFKRRPPEDAIAVSETTSLPTLPLDLREFQMQQEKELLQLSLQQGKYNQKRAAELLGLTYHQFRALLKKHQI
The following text describes a protein:
Function:
Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Upon binding to cdc48, required for sterol regulatory element-binding protein sre1 activation by mediating its release from the membrane and thereby regulating its activity under hypoxic conditions. Upon binding to cdc48, required for the processing of sterol regulatory element-binding protein sre2.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein.
Sequence:
MIFMILGRSKEFILKLPIWTQIITYIAILVYALSFFGISTGVLSLSWIGLLQKRQLYEIITYVTLHLSMLHIVFNFVSLLPAMSQFEKKQGTLACILVTVIPYTLFPGIMHLIVYHFFLRKDYVSIAGLSGWAFAFISASCVHSPQRLISFFNLFSIPAYCFPIIYLIMTTILVPKASFIGHASGAVMGYCTPFMLGSIPLKSWAQNVDPIFQSWVKNYHSFDQLSHAQLPIAEPLSTFSSFPGKGTRLGG
The following text describes a protein:
Function:
Sedoheptulose 1,7-bisphosphatase involved in riboneogenesis. Dephosphorylates sedoheptulose 1,7-bisphosphate (SBP), which is converted via the non-oxidative pentose phosphate pathway to ribose-5-phosphate. Has a fructose 1,6-bisphosphatase activity in vitro, but this is probably not biologically relevant, since deletion does not affect fructose 1,6-biphosphate (FBP) levels.
Miscellaneous:
MISCELLANEOUS: Present with 11500 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPSLTPRCIIVRHGQTEWSKSGQYTGLTDLPLTPYGEGQMLRTGESVFRNNQFLNPDNITYIFTSPRLRARQTVDLVLKPLSDEQRAKIRVVVDDDLREWEYGDYEGMLTREIIELRKSRGLDKERPWNIWRDGCENGETTQQIGLRLSRAIARIQNLHRKHQSEGRASDIMVFAHGHALRYFAAIWFGLGVQKKCETIEEIQNVKSYDDDTVPYVKLESYRHLVDNPCFLLDAGGIGVLSYAHHNIDEPALELAGPFVSPPEEESQHGDV
The following text describes a protein:
Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus, cis-Golgi network.
Sequence:
MSTKKSAAQAGQSLWSAMPKANSELFALTYGSLVTELVRDYEDPIEVNAQLDRIGHSIGVRCVDEFLSKADVAGMSLATQCQNLRDTAEVVAKMGFKMFLGIQAEVGGFSQDQRSFSIYLQDNPLATFVELPGDEQSGGDDLRRLKYSNLYCGVIRGALEQVNLKVECNIVRDTLKGDEVNEIRVELKEVLADGAGDDYKEE
The following text describes a protein:
Function:
May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Domain:
Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
Sequence:
IKIENPISSSPPGSTDTPQNDIFTIAVPFGGEVIRWQFIFDGTNQKISPDILLPSTGFDDFDPEFDDIKSLLHWDNENKDSLLLAVQETVHLFKEHQRQVCYGIDKNLSSELSELLTEVYLKRAPKTKAPKSLNVLVKIPVDLKPLLEMFSKEISERDSIIHSPLLLVKFDLEVKKAVPMPFLPSHFEKIIGSKDQLNIPPYTMSTTIHQYVKKVEEKLTEVVQTVVTSQSKRCEYVAAFLRQFPADVLEYDAQNFSSISLVFSYQTFYFLVHISLSKFFPQNLPSVTLQSAYHLTKQDELFKKTFTNYPYSPRWSGTEMAKRTKNFILEKIPLFKDSCIRNGVL
The following text describes a protein:
Function:
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).
Sequence:
MALPLVTVRLVKFLAIYLALSTAFVVAKITLAFLDIFSPDAKDRLFQRVLANAKSMCPKGDTFQIEEFLTLKSYKALLYSQAVGIFKVVRKGRPAEDSALVQLDGQTETTLLSYTSGTRPLVVCFGSYTCPPFRDALSDFAVLAQDYQNVANFLLVYIEEAHPSDGWRFNSGPQIQQHRTVEQRCDAARAMLRDRGVQFDVAVDTMGNAANHTYGAFPDRLYVIQNGVVAHEGGKGPFLFNPTEVREWLNEHLNGLDKNNNTNDRK
The following text describes a protein:
Function:
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.
Subcellular Localization:
Nucleus.
Sequence:
MASGVHGKTVKGGALEESFPEDAQTQPGSAPPQSTLAAELVEGLPNESRRAKPDEVTEIKRLCTIIEQEKDKAGSDLEKTHEGRLAYNHILFYVCAGPVLDVVKTNDPFADFASLQLKAQNTLSLLKLAVQETPDVLKQTTDGNEFLLRGPEPLWLWFQPRLLALLGRSKLLGITSAIEDFFHFTLQTVAERVPLWDLGPGLLQYFQASLHAILEHFQSNPLADMNARNSNLDIQLPPDTFLRALDLDDPDTPSKFFYKIRDSEHAIRHAISLFHILKSTILPVGAAEPPLLYRGNIAWLMDVFQPLFSALVHWSPQLKISLAPYVQTAIDLAEAADDTLRPKAISALALICGEVFDRSAQYLGEDEFGLATRKALSLALLHLVKEADSHRSLMQLFESRVVIPAVSFATASLPNSDLWRSAILLQQVVSAETSFSQVPEELSSSKFVDVTLRQQVGLLGLDPVVEDGEPAPKRRKLVEHQALSADIVEEICRVANLPISEDICSLEDSLIDAFPKLTILRQCRVIELISFVPCATDNTLGLEEGRLGSLALSSASLECSHCSIFGYSAFTQACDDAVTKTTAYKILEKLVKSPGFRDSRRPRVYAIVRLQRMLRHTVLPEFRDLEQSILGQWCVQSLRSSIRELRIGAGRALAVLLDPDVPDFVRPIARGNQNIVLDILKLITDEDALHLHETCILAWGQAGRVVSVDHLNLILIKLVEYLGYNNSVVSSMAVNEILNIATYRGITPLQLFAPYWENMAVLVVKDLVSAPQTTRLVAETLQLSIEELLCLLQKHALPWLVLAKNLGVIEKIAEARGEKSTSQPCIDSANFPSIIALLLIQDVPDVEEHAMELLCVISPKFKEPNPGELNSDEKRPVSVRDRLAEILRVEPLGVLFELFKASGGADERKKALIRKGISILATRSSPLTEKGAEPPHIIERFLEKYTLGLVSRLSERITDIDVPIPDRRRCLRAMEEMIRVCRSSVTTARSQISACLLSALGCDELRSDAFSCWSVMIMNMDEMDVPNLLDTTLWVITHHWTCFDDSTKQQAQGVLDALSKTNGHDLVKATASMTTFNHLPDLAEHRKRLGLLSQSGLTRQDLFRTFCRRLRHDHPGVIEQALTELLELLRQHQDYIQASALAEQPKSFIPGLTRSVLDCAAKYNGWQPGIMRLCAECMGIIGCLDSNRMESNREQKRFVVSQNFMDFRETADFVCFMLENVLVKAFLSTTDTKFLSFLSYAMQELLAKTGIKLAYQSQGQGQHETLYKRWRSFNDITKEILTPFLTSEFIVSSGMIGLDTNYPIFHPQKSYETWLKTFVLDLLRNPQNPNSAILFPPLCRLIKVHDPCVSEFLLPYVVLHAVIGSEGPSQTPDESQMLVAEEGSTRAEAHEKKTSGSEWRKKVMSELKTILEYQPPETATHSEKEEVKLCYEAVFRILDYFKNWLHIKKSQSATKEKDARWCPLVEEVLSSLDPELVARRAIDCGQYARALLFLEPHIESRRDEAIGDEATRLMRSVHDIYTQIDDPDGLDGISACMKDLGFKEQALSHRKAGRWTAAQTWYEIQLAESPDDVNLQLDLLTCLEESGQYDNLLSFAEGIDKTPSSLSKVMPFVLEASWATGRWQIMEKYLRSYTEGDVTDVFNIGIADALLCLKEGDGERFQELLQAMRDKVASSMALSATSSFRTCHDVMLKCHVLEDLEMIANAEPVEGEGHAPLVKALERRLEVLGAYVSDKQYVLGVRRAAMELMRTKFGDEEISSSWLATARLARKSGSTHQSFNAVLRAQQLGDSSAVIEYAKLFYKDGQHRKAIQLLQRAIDDDLFNDGMMAIDTPTSSKSQQSHRNLLKARAHLLLAKWLDSTGQTHAGALRSKFQEAAKTHPQWEKGHYYLGRHYKKVLESEKALSPDDQSDAYLTGETAKLVIENYLRSLNFGTKYVHQTLPRILDLWLELGTQVDAPSLGMVTLSAELQSRRRTILHELYKHFNRHLPKMPAYIFYTALPQIVARIAHPNQDVFRVLEQMIIKVVEAHPRQAIWSLFSFMTGRTNGARRHRGQKVLDDLRAIAKRVDETGYDLKQLLKMGEKLAEQLLLACNKGDFQSNRTVKASITRDLNFNHKCTPCPLVVPIETCLTATLPTLTDNTRKHKAFSGDVITIDRFLDDVLVLGSLAKPRKLTARGSNGQLYGLLIKPKDDLRTDQRLMEFNGLINRSLKRDTESSKRQLYIRTYAVTPLNEECGIIEWVDGLKTLRDILLGIYKTRNITPNYGQIAELMKQACTSDDNLHLWSRSVLGMFPDVLPEWFISQFPDPSAWFAARLRYTRSCAVMSMVGTILGLGDRHGENVLLEEGNGGVFHVDFNCLFDKGLTFAQPEKVPFRLTHNMIAAMGIYRYEGPFRNCSELTLKVLRQQEETLMTILEAFIHDPTLDLQRTKKRTHDVVKLNPTSVVESIKRKVRGLLPHEKIPLGVEGQVEELIKQATDPKNLAAMYIGWCPFL
The following text describes a protein:
Function:
RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.
Miscellaneous:
MISCELLANEOUS: The RBMY1 proteins are encoded by repeated regions of the Y chromosome. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes; MISCELLANEOUS: Overexpression of Rbmy proteins in mice carrying the Y(d1) deletion that removes most of the multi-copy Rbmy gene cluster does not have any effect and fails to reduce the frequency of abnormal sperm. These results raize the question of the role of Rbmy proteins in sperm development.
Subcellular Localization:
Nucleus.
Sequence:
MAETNQPGKIFIGGLNIKTRQKTLQEIFGRFGPVARVILMRDRETKKSRGFAFLTFRRLADAKNAVKEMNGVILDGKRIKVKQARRPSSLESGSKKRPPSFSRTRGASRILKCGRGGRSRARSGPSCEGNLGGDRYTPNFNVSSSGRHFAVKRNPSSKRDDPPSKRSATSAQTRSNTGLRGREPHRREISRNMPRGEPASSRRDEYPLPRDYGQSSNDRKYESTSRGYCDYGNYHSREESASKVFSDHAGYLGGRDRDFSEYLSGNSYRDTYRSYGRFHEAPSARGGNNRYDDYSNSQDGYGGRGEPYISNRSNIYSSDYERSGRQEVLPPPIDREYFDREGRQERGHSPKDGLYSASRESYSSNTKIWGIPWRSWRKQI
The following text describes a protein:
Function:
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSSSPTFKDKDEDLEAQVPLNPQPSNPTVRTEQEVSGTTKLLYLAVYFLCNISLTIYNKLILGKFSYPWLLTALHAGSASIGCYILLLQGRFTLTKLSLQQNIVLFLFSILFTVNIATSNVSLAMVSIPFHQIMRSTCPFFAVLIYRFRYGRSYPRDTYLSLIPLILGVGLATYGDYYFTAAGFLLTFLGVILAVVKTVATNRIMTGALALSPLETLLRMSPLACAQALVCAIASGELAGFKEQNPEGPSGALILTLAGNGLLAFCLNYSSFSTNKVAGAVTMTVCGNIKQCLTILLGIVLFGVKVGFLNGLGMVIALAGAAWYSVVELRSKTQKGGR
The following text describes a protein:
Function:
Forms the helical nucleocapsid (NC) in a ratio of 1 N per 6 ribonucleotides, protecting the genome from nucleases (Probable). The encapsidated genomic RNA serves as template for transcription and replication; encapsidation by N is coupled to RNA synthesis (By similarity). Forms the encapsidation complex with the phosphoprotein protein P (By similarity). Before encapsidation, the newly synthesized free N protein, so-called N0, is chaperoned by P (By similarity).
Subcellular Localization:
Virion. Host cytoplasm.
Domain:
Ncore is globular and carries the regions required for self-assembly and RNA-binding. Ntail is an intrinsically disordered monomeric domain in the C-terminus.
Sequence:
MSDIFDEAASFRSYQSKLGRDGRASAATATLTTKIRIFVPATNSPELRWELTLFALDVIRSPSAAESMKIGAAFTLISMYSERPGALIRSLLNDPDIEAVIIDVGSMLNGIPVMERRGDKAQEEMEGLMRILKTARESSKGKTPFVDSRAYGLRITDMSTLVSAVITIEAQIWILIAKAVTAPDTAEESETRRWAKYVQQKRVNPFFALTQQWLTEMRNLLSQSLSVRKFMVEILMEVKKGGSAKGRAVEIISDIGNYVEETGMAGFFATIRFGLETRYPALALNEFQSDLNTIKGLMLLYREIGPRAPYMVLLEESIQTKFAPGGYPLLWSFAMGVATTIDRSMGALNINRGYLEPMYFRLGQKSARHHAGGIDQNMANKLGLNSDQVAELAAAVQETSVGRQDNNMQAREAKFAAGGVLVGGGEQDIDEEEEPIEHSGRQSVTFKREMSMSSLADSVPSSSVSTSGGTRLTNSLLNLRSRLAAKAIKESTAQSSSERNPPNNRPQADSGRKDDQEPKPAQNDLDFVRADV
The following text describes a protein:
Function:
Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MLSLGDLVRDWHRGAQAVARGDWGCALRLFSGIPEPPARMSFNVGCVHLLAGDPEAALQAFDQAVTRDACLAVGFFQRGVANFQLERFQEALSDFQLALAQLKDNATIDYTQLGLRFKLQAWEVLFNVAAVQCQLGLWAEATRSLEEAISKGPEGARGDLDIALGQVQEQAPLQPRQVPRGEVFRPRQRHLEHLEPVDFLGKAKVVASAVPDDQHQGIRPQQPQAGNEHGEARPRAAARAGTPCGPRKPPDVEMEMGCGQAGQAEHGRPLTSAKQSPHVERVDQQAPPGPTCSPPSAGLLAAEGPDPGSSEDPAGAGGVATGQPAALVTVLVQCAFTLALRAPRGADLSSLRALISQALPPQAQCGQLSYRDPSDGSCWVPLTGEEALQTAWREAATGPAGLRLQCRGVGGRPVLYQVVAQHSYSAQGPADLALQPGDTVDVLCQVDQAWLEGHCDGRIGIFPKCFVVPADRRV
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MSNNSNNNIKTYYIIGIITLIFIVSAVIKNQLSSSNQEQQEEEEETDSMGKSKGRGNKKGKKPEKIQEKKLDNHLKNLEKVKLQEDFKLQQDEKQQLKKEETILVEKQEIVVDELKNKKDEEKQQQQQEEDQQQQQQQQQEEEEEEEEQQEIEEDEEEEEGQEQEEEEEQQEIEEGEEEQQEEEQEEEQFSMFGVSIERLMDFQRQEDENEGSDEVEESSKVPIVLSFMLDRIKNLNGFKTEGLFRVNGNLKLVEQLATEGFDPFSDDLDPNVNTWASLLKKWIRDLPEPLIPHELNPIILDFCTNNNINNTCNNNNDNNNNNNFNVCASTNNLGNVLNLSTNICNNNNNNNNNNNNNNNNNNNNDNNNNNNESIEKKITNIINMIKSDDHRNVLYKIGEFFGEMLQEETVLITKINVESLSKILTPSLFKPNNIIDDFSNGSLNGSGNQIPKYLTTLDLPSILLKQKKEIAFVSCLLNYFKDEYSKKLQEQNDQEEDNQEEEKDNQEEDEDEEDKDQEE