lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
Subcellular Localization:
Mitochondrion.
Sequence:
MRVSLGSFFWFLLVAAALPQALAEIHNGVAYLTAVGREGGPFTLMVVVRLDGQQVLYYDSTRRELVLKLGWLYRALGARRIREKQQKLKAYEEDFRWAVENWMSKHNESGGTHIVQVLVGCEMDGDTQVGSSFKFAYNGMDFCWLDELQGGWVAASPAVLRFEPFQQESTFWSKGVRSYVKEECVTLMRHALRYWQLRELSPPEVTVTRKDAPDGSLTLSCLATGFYPSSILLRWVKDGEKGLWGEESSSGTLPNADDTFYLRQTLELRAEVGDSSYVCLVEHSTLGVPTAYPAPRKPTWWIPWSLALGVAAAAGLVLSPAVGFILWRKKKQGLQVQDLTAERVQQNGIRHCSYTASRNNLYVNKTTKVICQGFTGKQGTFHSQQALDYGTNLVGGTSPGKGGKTHLGLPVFNTVKEAKEQTGATASVIYVPPPFAAAAINEAVEAEMPLVVCITEGIPQQDMVRVKHSLTRQSKTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSFCVGIGGDPFNGTNFIDCLEVFLKDPSTEGIILIGEIGGNAEEDAAAYLKQHNSGPNAKPVVSFIAGLTAPPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVVVSMSPAQLGSTMYKEFEKRKLL
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MENNSLPMDPAMDSSFMDGLLLEGCWLETTDASEFLNFSPSTSVAPFDPSSFMWSPTQDTSNSLSQMYGQDCPERSSLEDQNQGRDLSTFNRRWWIGPSGHHGFSVMERLVQAVTHIKDFTSERGSLIQLWVPVDRGGKRVLTTKEQPFSHDPMCQRLAHYREISENYQFSTEQEDSDSSSRDLVGLPGRVFLGKVPEWTPDVRFFKNEEYPRVQHAQDCDVRGTLAIPVFEQGSQICLGVIEVVMTTQMVKLSPDLESICRALQAVDLRSTEIPIPPSLKGPDFSYQAALPEIRNLLRCACETHKLPLAQTWVSCLKQSKTGCRHNDENYIHCVSTIDDACYVGDPTVREFHEACSEHHLLKGQGVVGEAFLTNGPCFSSDVSSYKKSEYPLSHHATMFGLHGTVAIRLRCIHTGSVDFVLEFFLPKNCRDIEEQRKMLNALSTIMAHVPRSLRTVTQKELEEEGDSMVSEVIEKGVTLPKIENTTEVHQSISTPQNVGLVFDGGTTEMGELGSEYGKGVSVNENNTFSSASGFNRVTEKKRTKAEKNITLDVLRQYFAGSLKDAAKSIGVCPTTLKRICRQHGIQRWPSRKIKKVGHSLQKIQRVIDSVEGVSGHHLPIGSFYASFPNLAASPEASSLQQQSKITTFLSYSHSPPAKSPGSSCSHSSSCSSETQVIKEDPTDKTRLVSRSFKETQTTHLSPSSQEDDFLRVKVSYEEEKIRFKMRNSHRLKDLLWEIAKRFSIEDVSRYDLKYLDEDNEWVLLRCDDDVEECVDVCRSFPGQTIKLLLQLSSSYLPERSSVSGCLS
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSAQTNSGIQQLLEAEKVARNIVEKARQHRTQRLKDARLEAKREIDEYASKKEEEFKKSESQASGIYSQAEAESKKQVQDTFASIETSSQKNSDKVVDAILSITCNVK
The following text describes a protein:
Function:
Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position. Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity.
Subcellular Localization:
Apical cell membrane; Single-pass type II membrane protein.
Sequence:
MSWWKILLGVLGGAVLLAVGLLIGHFGITKTKTINPEWVEELSQDVDEAFIKEFMKEVDNKKIEEHLKELSKKPHMATTTGDEELVKLILARWNHAEYGLDDAKQERYNVYLSFPDKNKPNTVKVLTDNGQNPFTCRLTEANVTPDQEDPEVVQPYAAYAPSGNPKGKLVYANQGKLSDFQYLADQSITLNGTIAIVRYGGAGRAAKAINGAKFGVVGIIVYTDPKDINDGLAERNQTYPYSWYMPESGVERGSYSEDFGDLLTPYYPAKDYTYRIKKSEINGIPPIPTQPIGFEDAKTLICQLAGPVAPQSWQGSLGCPYNLGPGFISSGKFNNSDVQVNVYNYDEIKPSANVMGIIRGSVEPDRYVMYGNHRDSWVHGAIDPSSGTAVMLEITRVLGTKLKQGKWRPRRSIIFGSWGAEEFGLIGSTEFAEDYYSKLRDRTAAYINVDISVFANATLRAQGTPPVQDVIFTAAKQVQTPASSALSVYENWIRYANRFSTLYQKTIPQLGTLGAGSDYAPFLHYLGISCMDISYTYDRNKTSARIYPAYHTAFDTFDYAAKFIDPGFTSHQTVARTAGNVLLRLSDSLILPLGPLDYWETLDSYYNTAESTFGSTLTSKGISLAPLKAAVEQFKKASEALKKTIDELKADNERPLSVRMINDQIMLLERAFINHYAFPEKRYYSHVLWASRSSSVVTFPGLADAYARASASNLEDDWDLVRKHLTIVIYAVTNAASTLETAASI
The following text describes a protein:
Function:
Probable lyase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides. Mediates the dismutation of the unstable peptidyl(2-hydroxyglycine) intermediate to glyoxylate and the corresponding desglycine peptide amide. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MRASTACLVALLAPFYISALPVEYFYGDEQQPIEEGAENSAVFEQDRELIGLFNPSKEIGQVSGLAVNKNGHIVAFHRSGRVWDEKSFNDHETFNKDLGVINNKTIAIISREKKVIDEFGAGLFYMPHGLTIDNNGDYWVTDVGSHQVHKIDAKTQKIVMSLGEKMVPGEDQAHFCKPTDVAVAKNGHIFVADGYCNSRILKFDAKGNLMAQINAATEENQPSEFVVPHSLSLIEDMNIVCVADRENQRVQCFSAGLSEGDRTLPTGIPITSATDIGRVFAIREREHYLIGVTGNSEDVEAQMFSIDMQTGKTETFAKGVRNTHALAIAADGVMFVSQLEPSRILEIRLL
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MMEENKRVLLGMSGGTDSSVAAMRLLEAGYEVTGVTFRFYELNDSTEYLEDARHLAERLGIRHITYDAREIFRKQIIEYFVHEYMVGHTPVPCTLCNNYLKWPLLSKIADEMGIFYIATGHYVRKVKVDDTCYITYAADSDKDQTFFLWGLKQDILRRMLLPMGDITKVEARAFAAERGFQKVAVKRDSLGVCFCPMDYRSFLKMWLVSNCQPQVSVGQPQVSAGQTWSAEVRRGRFVDEKGDFIAWHEGYPFYTVGQRRGLGIHLNRAVFVKEIRPEKNEVVLASLQALEKTEMLLKDWNIVNRERLLGHADIIVKIRYRKQENHCTVTVTLDNFLHVQLHEPLTAIASGQAAAFYKDGLLLGGGIIVE
The following text describes a protein:
Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MLQINSKGSVTLSTRCKGLWRECVWDRFVKIWTCDVFSSYLNPHPAGIVLTRALIIASSIMSVLAFAFLVFGFKNFTCFHDPSIKLQCLRLSSGLHFLAGMSSCAGIIRYCVYVYGNHQYEVSLRIPGFPSFEYGYSLWVAVGGSLGALVTAAITCYLSHAQKKPDVMTLNAINEVTHCNAQEVLKTYV
The following text describes a protein:
Function:
Converts the D-glycero-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position.
Subcellular Localization:
Cytoplasm.
Sequence:
MESAKVLFLDRDGTINRDIGRYVSSREEFILIDRADEAIAIAREAGFRIVLITNQAGIARGIVTPQDVEDVNDYLNELLAERQTSFDRCYYCPAHPNYPHPEYDRFIDHRKPSPRMVEQAIADLREEGFEVDRSASFFIGDKLIDVECGQRAGLKTILVRTGHNEESLCEQHQIFPDHVADDLYQAVTGYILGQPTSRD
The following text describes a protein:
Function:
Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MVLDRQSAAVANSVHSPRKKLRIGFVHPDLGIGGAEKLVVDAALSLQQLGHEVVIFTSHHDPRHCFEATRDGTLKVQVMRTAIPRSLLGGFHLPCAILQQMSLVFQLILAVTLFNYPGTMPRFVSKRMTSSPPIPGFDLFFFDQLPAGIPWLKIILATRVVYYCHFPDKDISNSIAMQRAHARGESGPSVLRKLYRIPFDLFEEGTTDYSDKILVNSEFTSAQFVKSFFRLRRQPRVCYPGVEMDQFKPERVEQALKKLETEAKQMGDPIRGSIAKFCKDESKTTLLSINRFEAKKNVALALEAFAIAQKELAATATNGDSVGSLRLVLVGGYDKRVRDNVATLNELQTQAQELGLSSVTLSYHRQAFETPTTAPAADKLAKASVIFLPSLPMALIHTLLLNPATRALLYTPTDEHFGIVPLEAMACGVPVLATNTGGPVETVVDLALSSTGEPTNLSNGTGLLRHASAPIWAVSITALLRLSSSHREQISAAAKERVRTKFSTEVLSLALEKACYDAFELGRVRGDEGLYQWGSTLAVLMVMSILFWVNVYFSHDKWLAIQAAKLANEKDKWLAELKATGVAGSAGGLNPHADHVAQAPLPTPL
The following text describes a protein:
Function:
Broad-specificity glycosaminoglycan lyase.
Sequence:
MYAPSRLKLIALTMTTLLGTAAYTPHLSANNTKSAKTEVSQKALMQSSIIDFDGNQLPDFVTASSGSTLSLSSTRYIMGQQSLKWEWQAGSTMTIEHPITLVTDKVASKTWGRKATQVLSFWIYNETPVDDYMIVDLGRGLGPSGAPDAGIKVKMNFSGWRTVGVSLQNDLEGREIEGIGFDDNAEGESGGRSTIAGGAKSDMDSIRFRAPLKAPAGIFYIDRVMLSIDDARYQWSDDHVKTRYQIPEINFRLPAKLPAPTAGEIAAADDIRGALIRVFTEGQGGENGLVVVDNREKLRAHFAALKIQRDADGQLSGRHIITDKQKVLYQPEFMDDIDQQRFSDYVLLGDYTTLMFNISRAYQRSTSEEVRQELADMYILMTQHLLDQGYMDGSGLVTTHHWGYSSRWWYISAMLMANELDKHQLRQPVSDALLWYSREFKANFDMVPGPESSDLDYFNTLSRQHLALLMLESDPAKRVALLKRFGEYINVALSQTPPGGYDGLRPDGTAWRHEGNYPGYSFPAFKNAGQLVYMLHGTPFAVSDEGRAALKKAMLSAWVYSNPATSLGLAGRHPFNSSSVTLFQDAFRWLALTGDPKTGDKVDKALAAAYLQITETPESESEAIFGVRIAPAELPQGNWTFNGGAFGIHRFSDKMVTLKAYNSNVWSSEIYYRDNRYGRYQSHGAIQVLPYGNQKEIGFVQDGWDWNRNPGTTTIHLPLAELDSPNTHTLMLRGNHPFSGHSSLSGKYGMFAFKFDAPSMPKFDSSFTARKSALETENRLVLLGSNISNNTEKYATETTLFQHGITDKASDLWVNGERITALPYQRALEEGDWLIDGHGNGYLLTKGAKGEVRRQHQVSANDKSRDPTEGNFSLAWLDHGAKPQNAQYEYLMVLEATPEGMQQLATDYRAGKKVYEVLRQDASAHIVRDNVTQTTGYAAFSSVTPDEGVVKNIAQPAIVMTQMQSHGQLKISGVTPDLNMTRTTKATPLAIAVTLNGQWQATENNPQVSVKLAGETTQLVFTSYFGMPQEVTLKPMN
The following text describes a protein:
Function:
ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSESKSTSWADEVASPSTEKNEESSLEDAQVDGATEPLGGGTLQDGQYEVEVKLSDIQGDQTSPLYSVDTFEQLGIDASILKGLYAMNFKKPSKIQEKALPLLLGNPPTNMIAQSQSGTGKTAAFVITILSRLDFSKPTTPQALCLAPSRELARQIEGVVRSIGQFVEGLSVQAAIPGAVERNARVNAMVIVGTPGTVMDLIKRKSIDASQMKVLCLDEADNMLDQQGLGDQCLRVKSMIKVEQILLFSATFPDEVYGFAQQFSPRANEIKLKRDELTVSGIKQMFMDCPNEVGKYEILVKLYGLMTIGSSIIFVKRRDTASHIAERLTAEGHKVAAIHGAFEGAERDTVLEDFRQGKAKVLITTNVLARGIDVQSVSMVINYDIPMKGRSDFEPDPETYLHRIGRTGRFGRVGVSISFVFDRKSYDALNKIAHHYNIDLIKLNQDDWDETEEIVKKVIKSSRAGTNLRA
The following text describes a protein:
Function:
Fatty acid desaturase that introduces a cis double bond at the 5-position in 20-carbon polyunsaturated fatty acids incorporated in a glycerolipid that contain a Delta(8) double bond.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The cytochrome b5 heme-binding domain acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome.
Sequence:
MPPRDSYSYAAPPSAQLHEVDTPQEHDKKELVIGDRAYDVTNFVKRHPGGKIIAYQVGTDATDAYKQFHVRSAKADKMLKSLPSRPVHKGYSPRRADLIADFQEFTKQLEAEGMFEPSLPHVAYRLAEVIAMHVAGAALIWHGYTFAGIAMLGVVQGRCGWLMHEGGHYSLTGNIAFDRAIQVACYGLGCGMSGAWWRNQHNKHHATPQKLQHDVDLDTLPLVAFHERIAAKVKSPAMKAWLSMQAKLFAPVTTLLVALGWQLYLHPRHMLRTKHYDELAMLGIRYGLVGYLAANYGAGYVLACYLLYVQLGAMYIFCNFAVSHTHLPVVEPNEHATWVEYAANHTTNCSPSWWCDWWMSYLNYQIEHHLYPSMPQFRHPKIAPRVKQLFEKHGLHYDVRGYFEAMADTFANLDNVAHAPEKKMQ
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.
Subcellular Localization:
Nucleus.
Sequence:
MAGSETAKATTTGITTTDNTMSQPTKPMVRRFVGVRQRPSGRWVAEIKDSSQRVRLWLGTYDTPEEAARAYDEAARALRGENARTNFAPVNHNSSQSGSSPSNGGFVSQSDGRHGLSFSSLKAKLSKNLQSIMARTTENKSTKSRVSDHFTFASIFHFRNYQYQNPPVDMKNIEKVVQPSIIVPRAVDEPPSSNWDSSSVSDCSNEWVGFRQHGFDSDGSDIGEVSFGDQGFADQMMGWMDSPEISPRIMSPADGGSRSKRFKVSSSVVVPPTFSGSTCNTDN
The following text describes a protein:
Function:
Mediates clathrin-dependent trafficking of vacuolar cargo from the trans-Golgi network (TGN). Promotes plant growth.
Subcellular Localization:
Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Colocalizes with clathrin at the trans-Golgi network (TGN).
Sequence:
MDTSRRAVESYWRSRMIDAVTSDEDKVAPVYKLEEICDLLRSSHVSIVKEFSEFILKRLDNKSPIVKQKALRLIKYAVGKSGSEFRREMQRNSVAVRNLFHYKGHPDPLKGDALNKAVRETAHETISAIFSEENGTKPAAPESINRRIEGFGNTNFQVPSNDNKSFLSEVVGIGSASIKQGISNFAQGHLPKKNENGSSSYRGPNLHRSLTMENENFSRYDPVKLGKDGNYGTSKNTTGGSWGHASGEASESSASVRVESKTREEKLLETIVTSGGVRLQPTRDALHVFILEAAKMDAVALSIALDGKLHSPMWQVRMKALCVLEAILRKKEDENFSIVHTYFSENLDAIQRCAESPQSSLREKANKVLSLLNGGQSSGLMSSSDNTVKREAAVDLPDLIDTGDSDDTLNNLNAIDTGSTVATAGPLMDDDWFGDSSDIGLSSSEKKTDDDPFADVSFHPNEEKESADDLFSGMTVGEKSAAVGGNHVPDLFDMFGSTAKLEAEPKDAKNINDLMGSFSIDENNSNQKGSSSSTLPQDLFAMPSTTSHQAPENPVGGILGSQNPGFIQNTMLPGGVMPFNFPQGMMMNPAFASQPLNYAAMASLLAQQQQYLGNMSNFQQFGNLNAQGSGNVLSMGTSGGNQSALPDIFQPNFGNQAPTSTMNGSKKEDTRAFDFISDHLTSARDTKRVS
The following text describes a protein:
Function:
Intake of glucose and galactose.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKKNTYTIPLALVFSLFFLWAISSNLLPTMIRQLMKTCELNTFEASFTETAYWLAYFIFPIPIAMFMKRYSYKAGIIFGLLLAAVGGLLFFPAAMLKEYWAYLCIFFIIATGMCFLETAANPYVTVLGAPETAPRRLNLAQSFNGLGAFIAAMFLSKLILSGTHYTRETLPVDYPGGWQAYIQLETDAMKLPYLILALLLLAIAVVFVFSKLPKIGDEGAEPASGKKEKLIDFDVLKRSHLRWGVIAQFFYNGGQTAINSLFLVYCCTYAGLPEDTATTFFGLYMLAFLLGRWIGTGLMVKFRPQGMLLVYALMNILLCGVVMLWGGMIGLYAMLAISFFMSIMYPTQFSLALKGLGNQTKSGSAFLVMAIVGNACLPQLTAYFMHVNEHIYYVAYGIPMICFAFCAYYGWKGYKVID
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP42 is specifically important for nuclear protein and mRNA export.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: SXFG/PXFG repeats are especially abundant in NUPs on the cytoplasmic side.
Sequence:
MSAFGNPFTSGAKPNLSNTSGINPFTNNAASTNNMGGSAFGRPSFGTANTMTGGTTTSAFGMPQFGTNTGNTGNTSISAFGNTSNAAKPSAFGAPAFGSSAPINVNPPSTTSAFGAPSFGSTGFGAMAATSNPFGKSPGSMGSAFGQPAFGANKTAIPSSSVSNSNNSAFGAASNTPLTTTSPFGSLQQNASQNASSTSSAFGKPTFGAATNTQSPFGTIQNTSTSSGTGVSPFGTFGTNSNNKSPFSNLQSGAGAGSSPFGTTTSKANNNNNVGSSAFGTTNNQSPFSGGSGGTFGSASNLNKNTNGNFQSSFGNKGFSFGITPQNDANKVSQSNPSFGQTMPNTDPNISLKSNGNATSFGFGQQQMNATNVNANTATGKIRFVQGLSSEKDGILELADLAEETLKIFRANKFELGLVPDIPPPPALVA
The following text describes a protein:
Function:
Possesses calcium-dependent ppGpp (guanosine 3'-diphosphate 5'-diphosphate) synthetase activity in vitro and is able to functionally complement E.coli relA mutants. May be involved in a rapid plant ppGpp-mediated response to pathogens and other stresses.
Subcellular Localization:
Plastid, chloroplast.
Domain:
The calcium-binding sites of the 2 EF-hand domains are required for enzyme activity.
Sequence:
MASAGGEVVVVDPAAAAVAPDVEHHAPAPRLTPAGSGGRLMAELLGVFNGLTERMGDDVATSSSWTLLFRALKLALPALRDAAGGRSLARALIVAASLADLQMDAEVISAGIVRQAMDAGAVAMADAEAQLGPGAAALLLESLDVKNAPSRVDVADEEAASAVRNRILSGYDVRAVILELAIRLDAMKHLDGVPKHQQRTTSLEVLKVFAPLAHAVGAGALSKELEDLSFWRLYPQAYAQVDQWLSGQEDDCKRVLATCKDDLLQALAADDELRHTVAGFDVKGRYKSRFSAMKKLVKDGRRPEDVHDILGMRVILDHRAGAGDGHRACIRTHEVIKGMWKDVPARTKDYIARPKGDGYRSLHIAVDMSEPGPEGKKRPLMEVQIRTKEMNDAAVFGHALYKGCLADPEEAKRLKDIMLAAAEVAAQHLRDEPATGDQTGVPAAAAAAASAGNIERAFRLLDKNGDGRISMEELTELMEDLGAGGKDAEELMRLLDDNNDGSLSSDEFALFQKRVELKAKLEDKDDEYKEILRQKLQKVDDTGLIHVYRKNLSDKLVSG
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MHEKHPRGPTFLTVAAVMACKLPASVHLHRYNPENLVTLEQYVDTQARENAYDLEANLAVLKLYQFNPAYFQTPVTAQILLKALTNLPHTDFTLCKCMIDQTHQQEERPIRQILYLGNLLETCHFQSFWTSLEENRELIDGIAGFEDSVRKFICHVVGITYQTIDHRLLAEMLGDPLDTQVKVWMNKYGWTENEDGQIFIYNQEESIKPKNIVEKIDFESVSSIMATSQCAESSARWFFTASHSSV
The following text describes a protein:
Function:
Involved in mitochondrial distribution and morphology. Mediates the import of UPS1, UPS2 and UPS3, 3 atypical mitochondrial intermembrane space (IMS) proteins lacking the two major IMS-targeting signals, into the intermembrane space. The UPS1:MDM35 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane.
Miscellaneous:
MISCELLANEOUS: Present with 3870 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Mitochondrion intermembrane space.
Sequence:
MGNIMSASFAPECTDLKTKYDSCFNEWYSEKFLKGKSVENECSKQWYAYTTCVNAALVKQGIKPALDEAREEAPFENGGKLKEVDK
The following text describes a protein:
Function:
Probable redox-inactive chaperone involved in spermatogenesis.
Sequence:
MLLLWVTFLLSSCLSGAQAWGGWDFQNDRIRKLEALGIQEEKNLLVLTATTLARVLNETRFLMVEFYNPLSKQSQNLIKEMGKAVDIMGKENPGVLFGKVNITSEKLLKQEFAINDVPTVKLFIEGHRQWPIDCRGVIEAAALVTWLRNQIRQSIVLLTNREQTKAFINSRKLIVIGFFEDLHEGTVELFYDLVKDFPEVPFGMIEKRDLWIRYGITIDTMVVFQQGKIVHFEECEEDSHILRDLSKIVKFFTMDLVIEYNIETMDQIYDMHIRNHILLFISKNSTEFDALVKIFELAALEFKNKLIFLIVNTDEIHNIHVLEYFQIASWDIPSVRILNLTKSMKYQMPADEITFKNLKNFCKDFLDGLAKQQLSSENIPKDWDTKPVKVLVGKNFKEVVFSHRRNAFVMFYAPWSYECKSLLPVLEELGKKYQYHESVTIAKIDVTANDIHQMFLEKYPFFKFFPAKTDLVVPYDGEYNLDAFINFVEKEIKSQMESEEWTFEQEESDEKEDLSIQDWGKIKEEL
The following text describes a protein:
Function:
May function as a proton-driven pyrimidine uptake system.
Miscellaneous:
MISCELLANEOUS: The Rut pathway degrades exogenous pyrimidines as the sole nitrogen source at room temperature but not at 37 degrees Celsius, a restriction that is apparently a consequence of an inadequate ability to remove toxic malonic semialdehyde at the higher temperature (RutE/YdfG function).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAMFGFPHWQLKSTSTESGVVAPDERLPFAQTAVMGVQHAVAMFGATVLMPILMGLDPNLSILMSGIGTLLFFFITGGRVPSYLGSSAAFVGVVIAATGFNGQGINPNISIALGGIIACGLVYTVIGLVVMKIGTRWIERLMPPVVTGAVVMAIGLNLAPIAVKSVSASAFDSWMAVMTVLCIGLVAVFTRGMIQRLLILVGLIVACLLYGVMTNVLGLGKAVDFTLVSHAAWFGLPHFSTPAFNGQAMMLIAPVAVILVAENLGHLKAVAGMTGRNMDPYMGRAFVGDGLATMLSGSVGGSGVTTYAENIGVMAVTKVYSTLVFVAAAVIAMLLGFSPKFGALIHTIPAAVIGGASIVVFGLIAVAGARIWVQNRVDLSQNGNLIMVAVTLVLGAGDFALTLGGFTLGGIGTATFGAILLNALLSRKLVDVPPPEVVHQEP
The following text describes a protein:
Function:
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by GAR1 to yield mature H/ACA snoRNPs complex. Acts as a competitive binder for CBF5 probably required to prevent non-cognate RNAs from being loaded during transport of the particle by inducing a non-productive conformation of CBF5.
Subcellular Localization:
Nucleus.
Sequence:
MSESTNQQETALREIVEDTTNANEPTAIDKTTLPNETSHERETTTTENASSEIENIEPQVATHNSDLDKSIPTDTNIISDVSQAPHVCPDNENTVQTSEDLQQSNVEKQKMEFHNGLEQSKEMATETEIEKFDDIQREISDPIDDESLKSTQKPESLETEKVEADASHKGLADEAEQLSDEEINVDDISSDDNSESSSSEESSGDSSSDESSDENETSNIDYNDVEDEDEDSNEGPVKSVHEIIDEKAPSLPDNYEISPNTPIEEIGEITGLVENTMIIKARTSGEFRILQEKSIFCFEDRTVIGPLFEIFGRVQQPVYSVKFNSEEQFSKFKESKGKTVYYVVPDSQFLYTDSIKHIKGTDASNCHDEELPEEEQEYSDDEKESAAKSAKKKKKNKKTKDKQTHTSGPSLPNKRQKVSAYSPITTYSQNAVHNRGRQISPQHNTIYSNYGQQQPPQQQQQQSPPVAQYGQPYYPQTDSYNSLMGQTPQYPQPTFGQSQHFYQNAYNQPVQPQYEPAYQPPQQYNQYQQQPQEQQQQQQFNPNMPNAQTQQQVDPAQLEHLQRLLLQHLQNNQNQYQHPPQ
The following text describes a protein:
Function:
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
Sequence:
MFRFDKEQIVLDIAGTKIGGQPGEYPTVLAGTIFYGGHSIIEDEKAGVFDKDKAEALIKTQEEMSDVTGNPHIVQTFGQTPEAIVKYLEFVGDITDAPFFIDSTSGEARIAGAEYASEVGLEDRAIYNSVNMAADESELEALKNTKLSASIVLGFNPMDPTVEGKIGIWEDGAGTIDKGLLEMAADCGIDKYLMDVAVTPLGQGAGVAVRTSFAVKSKWGYPVGSGIHNVPSAWDWLREYKKEHKEAWPVCDVGSNLIQQMAGGDFVLYGPIENARMAFPACAMADIFISEAAKDIGTEAVEDHPFFKLL
The following text describes a protein:
Function:
Role in flagellar biosynthesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Sequence:
MRIDVSLLPALAAAFMLVFARVGAMVMLLPGLGETNIPTRVKLSIALLLTLIILPLHRSAYHVDMGSLAPLLVLMLHEIAIGIVLGATARVTLSALQVAGSVIAQQMGLGFVTSVDPTQGQQGVLVGNFLTMLGVTLLFATDSHHLVIAALNDSYAIFSPGETVSSGDVASLATRAFAAAFRLGLQLSGPFLVFGLVFNIGLGVLARLMPQMQVYFVGVPLSIFAGFLVLAVVLTAMMGTFLDYFIGVMHQMMPLK
The following text describes a protein:
Function:
Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton. Cell junction, gap junction.
Sequence:
MGNNSGKERHGSSGAAVDTYETPPTSPYSVVSTWSPKTQLVSISNCTNTGTPETSQDTLSPPLESSVQNEPILVCKTGPGKEEEGLNMTQGLENVSYVSGVCLNGNTEVDAKLLQECLNTLQLSNIEESTHILNDLLHCFLVEREKMKEELRSCKEKIQAEREEWQQFQADLKVALVVSDRLRAEAEEELNTLRAARQDLGTQLADSLQGRREVEGQLESLRTELEKSKQKMKQVNGSHQGAATLRGLERRVEGSGKSTGHIEQLWTNEMKGKREISGNTERSRSLCRLPSDYTDAVVNGSSQPSITTTIESTPQSKTPAGSLDQQNNMTNSIKDKKVENSLPQTGTSSVLDVTNKVSRMRMQEDFPSGLRSLRLHGGSRRNSLLRWCQCRTQGYKNIEITNFSSCWVDGLAFCAIYHSYLPSHIPYNRLSPENKKENLTLAFQTGEGFGISTSLTVEEMLKDDAPDWHRVLEYVESIYRHFEM
The following text describes a protein:
Function:
Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKIAFTWLLYFAAFQVAWALDFATTRGPFLVNNATQSDITINGIWYSLSNSTTDTNAMDPLKDAKACTRDAALMAQAGINTIYVMAIDPKVNHDDCFSIFNSVGIYVVVVLRKDGVFGTSQEDFEKSYTTEFLKGMFEAIDAVKGYDNLLGFDLVGTTLHLIRNDELLDASYQTESHMYYFYCGEANDPSRSDYISFYNIGFFETSPVEKQNASYQSYQKKAEKSLVPTWFSYMGIFDEADYVEYELRPDLLNDTLFLFNSSSQLVRPNGLFTGGVRVSWTNTNMGWKVPGKANWGLTTTTPNGDVQLTPNYDAFRSIIDQVNPGSWLSGTQRPVQPGQERARCDANAKQMANKTLISLSQNDANNITLATDWALPTRPPGVDAMIENGVGAKTGRMVDVTVTSVAFAVRDSKGGVVTDLALKPSSSQARGPTGSGAAIGMPKSSGELSTGAKAGVGVGAGVSGLALIGAMGFLLLRRRKKRKSVGESDEAVKKTKDVDGYHKAELAAGREVEKQQAELDASGIGPQEVMASERKYELCTAVQQEPVELPVTEKPVEAPGR
The following text describes a protein:
Function:
May form a water-specific channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
MPFLHLFTPYTNADNTKLILRVNESRLRLFTRQLLAEFFGTLFVVYIVSGSTLAANFAVSDPIVRVCLICLVQGFAFAAIIWSISGISGCQLNPAVTVGCVTTGRMGILNGIAFIIFQCVGALVGAGMMKASLPTFYERDLSATTLATGVNVARGFFLEMVTTSFLVFVVLGVAVYNEWDPKISRVAPLAIGCAVIAGVGFLNLFTGGSLNPARSFGPAVFSDTWHRHYIYWFGPICGGIIAGLFWRIFLSEKVLLIDRPYTDFHRSTYGTATK