lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of clathrin-coated vesicles. Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle.
Sequence:
MELAHSLLLNEEALAQITEAKRPVFIFEWLRFLDKVLVAANKTDVKEKQKKLVEQLTGLISSSPGPPTRKLLAKNLAALYSIGDTFTVFQTLDKCNDIIRNKDDTAAYLPTKLAAVACVGAFYEKMGRMLGSAFPETVNNLLKSLKSAESQGRSEILMSLQKVLSGLGGAAASSHRDIYKNARSLLTDRSMAVRCAVAKCLLELQNEAVFMWTAELENIATLCFKALENSNYGVRVAVSKLLGTVMATALMPKQATVMRQNVKRATFDEVLELMATGFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAYVVFVTTLGGQWLERSFATFLSHVLDLVSHPRATQTHVEAVYSRRCVSFILRATVGSLLGEKAQIAAAKEICQAIGKQMKAVEAVVNDTSGENKSGAADIAASQHVMVCALQELGSLVQSLNATASPLIQEASIGLLEIVTSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNNLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDVIRKLMTPIECAMTMMSHIPSVMKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSYKHRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGPLDNPNPILRCAAGEALGRMAQVVGEATFIARMAQYSFDKLKSARDVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLTLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNGATTSTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSLAKNTGDKESSSANVSPFAPGVSSRTDIHCRHQGVNITETGLEGLLFGMLDRETDRKLCSDIHDTLGHMLSSLAVEKLSHWLMLCKDVLAASSDMSTATLLSSGKDEEAEKKDEMDDDTMFTTLGEEDKSKPFVAPRWATRVFAADCLCRIINLCENADQAHFDLALARSAKLRNPTNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVVAMNIKKEAESKPKRAIKNTDDDDDDCGTIDELPPDSLITLVQPELPTLSRLWLAALKDYALLTLPAEFSSQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFTCSESTEAAAISGLQKRSTSVNLNQASGAMGSAKSLPEINKDRMHLILGVSIQFLCSPRPEEPIEHVTACLQALHTLLDSPYARVHIAEDQLIGVELLSVLHRLLLTWNPSSVQLLVTGVVQQIVRAAQDYLQEKRNTLNEDDMEKEACTVLGEGGDSGGLIPGKSLVFATMELLMFILVRHMPHLSTKVSDSPSHIATKTRLSEESARLVAATVTILSDLPSLCSPAGCMTILPTILFLIARILKDTAIKSADNQVPPPVSAALQGIKSIVTLSMAKTEAGVQKQWTALIRSTLACILEYSQPEDSVPTPDEVSMLTAIALFLWSASNEIIGVQSLQNGCMNRFKNALNSCDPWVQAKCYQLLLSVFQHSNRALSTPYIHSLAPIVVEKLKAVERNRPASNIELLAVQEGIKVLETLVALGEEQNRVQLLALLVPTLISYLLDENSFASASSASKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELKVRLETAVRASQASKAKAAARQPAPAIHSAPTIKLKTSFF
The following text describes a protein:
Function:
Exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His-Asp phosphorelay.
Sequence:
MQVFIMRHGDAALDAASDSVRPLTTNGCDESRLMANWLKGQKVEIERVLVSPFLRAEQTLEEVGDCLNLPSSAEVLPELTPCGDVGLVSAYLQALTNEGVASVLVISHLPLVGYLVAELCPGETPPMFTTSAIASVTLDESGNGTFNWQMSPCNLKMAKAI
The following text describes a protein:
Function:
Pseudouridylate synthase responsible for the pseudouridine-2819 formation in mitochondrial 21S rRNA. May modulate the efficiency or the fidelity of the mitochondrial translation machinery.
Subcellular Localization:
Mitochondrion.
Sequence:
MNRWAVPILHEHKHYYIVNKVHGIVCQPPDLRTWYKYHDYEPPVLLDLLRKQHPNFGGEVWRTVHRLDEPVTGGVLVSRNKRAAAMFSRSLALGGNRGFPLTRRYVALLAREAKGLPSEGRITMGDMITDYKRLENDLVLLQLQTGRKHQIRKQMAQVFGQPVVNDKMYGGDSVDGIVDNLIGLHSAFIGAQCGLQARTYLIPIPRTQDAFKLWDKYIDEQGGFIPSVQKELRDFSLPSKLENTITLLSGGQGGIQISYK
The following text describes a protein:
Function:
Elongates the mitotic spindle by interacting with spindle microtubules to generate an outward force pushing spindle poles apart. Following spindle assembly, CIN8 and KIP1 apparently act to oppose a force, possibly generated by KAR3, that draws separated poles back together.
Miscellaneous:
MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Mitochondrion. Note=Spindle microtubules that lie between the poles.
Sequence:
MPAENQNTGQDRSSNSISKNGNSQVGCHTVPNEELNITVAVRCRGRNEREISMKSSVVVNVPDITGSKEISINTTGDTGITAQMNAKRYTVDKVFGPGASQDLIFDEVAGPLFQDFIKGYNCTVLVYGMTSTGKTYTMTGDEKLYNGELSDAAGIIPRVLLKLFDTLELQQNDYVVKCSFIELYNEELKDLLDSNSNGSSNTGFDGQFMKKLRIFDSSTANNTTSNSASSSRSNSRNSSPRSLNDLTPKAALLRKRLRTKSLPNTIKQQYQQQQAVNSRNNSSSNSGSTTNNASSNTNTNNGQRSSMAPNDQTNGIYIQNLQEFHITNAMEGLNLLQKGLKHRQVASTKMNDFSSRSHTIFTITLYKKHQDELFRISKMNLVDLAGSENINRSGALNQRAKEAGSINQSLLTLGRVINALVDKSGHIPFRESKLTRLLQDSLGGNTKTALIATISPAKVTSEETCSTLEYASKAKNIKNKPQLGSFIMKDILVKNITMELAKIKSDLLSTKSKEGIYMSQDHYKNLNSDLESYKNEVQECKREIESLTSKNALLVKDKLKSKETIQSQNCQIESLKTTIDHLRAQLDKQHKTEIEISDFNNKLQKLTEVMQMALHDYKKRELDLNQKFEMHITKEIKKLKSTLFLQLNTMQQESILQETNIQPNLDMIKNEVLTLMRTMQEKAELMYKDCVKKILNESPKFFNVVIEKIDIIRVDFQKFYKNIAENLSDISEENNNMKQYLKNHFFKNNHQELLNRHVDSTYENIEKRTNEFVENFKKVLNDHLDENKKLIMQNLTTATSAVIDQEMDLFEPKRVKWENSFDLINDCDSMNNEFYNSMAATLSQIKSTVDTSSNSMNESISVMKGQVEESENAISLLKNNTKFNDQFEQLINKHNMLKDNIKNSITSTHSHITNVDDIYNTIENIMKNYGNKENATKDEMIENILKEIPNLSKKMPLRLSNINSNSVQSVISPKKHAIEDENKSSENVDNEGSRKMLKIE
The following text describes a protein:
Function:
Catalyzes the synthesis of GMP from XMP.
Sequence:
MEKVLVVNFGGQYAHLIARRIREVGVYAEIASPEEAVIKASKEEVKAVILSGGPSSVYEPGAPDIDEGIFALSKPVLGICYGHQMIAKKLGGKVERGKGEYGKTIVKILVNDPLFDGWKPEEAVWMSHSDFVEEPPPGFHVLAISENGYIAAMRKGLIYGVQFHPEVHHTSKGRVMFENFLRKIARISDVWRPEDQITRIVEEIRSRVKGGDVIVGVSGGVDSTVTAVLLYKAVGQRVKAVFIDHGLFREGEPEEAASLLKSIGIDVVYIDAKERFLKRLEGVADCEEKRRIIGETFAEVFSDAVKQMPNVKYLAQGTLYPDVVESGAVKGADKIKSHHNVGGLPPWFQLELIEPLREFYKDEVRRIAKALGLPEDVVYRHPFPGPGLAVRIIGPFTREKLAIVRKATKIVEEELRKAGLFRKVWQAFATVGEDKWVGVKGDRRAMGYIVTVRIVESEDAMTADWSRIPFEILEKISSRITSEIPEVTMVTYAVTSKPPSTIEPC
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MADKESKIKNVDVASDNSRSSQEEEQDGNETKIDLGISFDKLTLGPKKKLLVIPLAGIIVHRAHRCSPASIPKNRRPDFSYGNFLVYKRPFCEEFLKFCFERFEVGLWSSAMERNIQKVLTHVIGEEKNKFLFTWDQSQCTNTGFMCLWNENKPVFLKELKYVWEKYSKYSSSNTLLITDTEKALLNPPNTAICPKKYDIDNEDDDFLGPNGELRLFLEGVAEAKDVQSYVKDHPFGEPAITPSHPDWKYYSKIIRFFEKKRSSDTDHKK
The following text describes a protein:
Function:
May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRLLPGMVMLMLALVISGSARATTDVMPFKDEAQEQQFRQLTEQLRCPKCQNNSIADSNAMIATDMRRRVYDLMQEGKSRQEIIDYMVARYGNFVTYDPPLTPLTVLLWVLPLAAIVAGGWIIVARTRRRVRLRREPLPADTPVCGARAGWGVYVPGAVIALAVGAGSYALTGSYPQVRAWQQATAQTPGLLARALDPQAQPLNEEEMARLALGLRTRLQNDAGNVEGWLMLGRTGMVLGNAGTATGAYANAYRLDPKNRDAALGYAEALTRSSDPEDNRRGGELLRRLVSRDHTDIRVLSLYAFNAFEQQRFGEAVAAWEMMLKLLPAGDARRAVIERSIRLAQEK
The following text describes a protein:
Function:
Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.
Subcellular Localization:
Nucleus.
Sequence:
MYGRPQAEMEQEAGELSRWQAAHQAAQDNENSAPILNMSSSSGSSRVHTSWNQGLPSIQHFPHSAEMLGSPLVSVEAPGQNVNEGGPQFSMPLPERGMSYCPQATLTPSQMIYCQRVSPPQQEMTIFSGPQLMPVGEPNIPRVARPFSGNLRMPPNGLPVSASTGIPVMSHTGNPPVPYPGLSTVPSDETLLGPTVPSTEAQAVLPSMAQMLPPQDAHDLGMPPAESQSLLVLGSQDSLVSQPDSQEGPFLPEQPRPAPQTAEKNSRPQKGTGRGGSSEARPYCCDYENCGKAYTKRSHLVSHQRKHTGERPYSCNWESCSWSFFRSDELRRHMRVHTRYRPYKCDQCSREFMRSDHLKQHQKTHRPGPSDPQANNNNGEQDSPPAAGP
The following text describes a protein:
Function:
Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
Sequence:
MSSSIPYSLIQKLTQPSSSSSSLLSRTNRLFHHQSPSTSIHPGQTGILLRRSISHRFSHSQPSSSHQEHPSISLNQTRNLEISNSNQVIHQSISSVNQNNLKLPRSSSSTISQPSEPSHEDILINSLPTSYNSSSTTTTASSSSSLEPPSFEPLQTQRETTSSAPNLTQQSPTKAPTSQVKRTTRTSKPAKQVINLTPRAIGHLSTLLDGPNPKLIRIGVKNKGCAGMAYNLDYVDQPGKFDEVVVTKNEEGKEIKVLIDSRALFSIIGSTMDWQESKLGNKFVFDNPNIKEECGCGESFLV
The following text describes a protein:
Function:
Metalloprotease.
Subcellular Localization:
Cytoplasm. Lipid droplet.
Sequence:
MAAGPGGGGPIDLRGCSAWLLTLGAFFLLSFRYAGAANCRHRAPAPDEVVYKVPQKSNHILKRHVSPQLRVKTVYDKSIESLTPEKRRLVKNQLFPQAISYLQMTFQVRKPSSSILLSRQCATNQYLKKRDDPRRYCHGTCSEYTRCGPVIVPEEHLQQCMVCSEAQWHCGPSGASDGRGIQDTDFVLYVSAMTTERCSQENIVAYAAYCQLESEMDRPIAGYANLCPNMISTHPQEFVGMLSTVKHEIIHALGFSAGLFAFYYDDDGMPLTKRYINGLPFFNESRGFYQWSDKVVRMVQRVWDVRGQKTLHHNVFLLVTPRVTEEARRHFDCPVLEGMELENQGGIGTELNHWEKRLLENEAMTGSHTQNRVFSRITLALMEDTGWYRANYSMAERLDWGRGKGCDFAMKSCKYWIDKLKKENQNLSPFCDTVRSNPLQLTCRQDQKAVAICNLQRFSTPLPQEYQYFDHIPGVLTDDLPFYGGAVEIADFCPFAQEFRWHQSGEFQRSSDCRASENQPASSKNYGAESYGPESACLEQRSAFVMEQCMKRMSYPDWGSGCYQVSCTEDGLQVWVHDTPYLCTKSGQILHVHVQMNSWLYEGNLVCPSCTAFCDMCPPERDPPLDNRTRAVPLDLCSHSPNLVVTLWLLTLNLLPVLAGFFLCVYN
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MGKASKGSRKGKKAWRANIRTDDIDDFFEKQTRDAHAGAAAIPSLPSDSLFFVDKPAASASTSAAGASDTTTKDIPVKRKIEKKREKVLYHESLLKRNPFVQPIPSSVVSKKDKKKAKKKELQETQGEKSVPMEDDSVVKNFDIWAVDGRGDSKAKKRSTTSVIPAVEVEPAGCSFNPPLEAHQDSLAQAVADEKRKEYMKELGPAPVPLIVPGEAITEEDKFFLDADDGDEDAAEEDGDQDADNSVGQRKNKTKRVTRVELNKRARRKERLRAEAEAKKMENISKEIDSLPNIMNEIAKEDKEKEKRRIRRTVVKEERRKLGPPRLGRHKFEPAPVQVLLTEEISGSLRKLKGCCNLARDRYKSIEKRGILAPSKRISKHR
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDSPDAESRFLEQLGQRVRTTRALRGMSRKVLAKVSGISERYIAQLESGKGNVSIVLLRRVSDAMGAHLEDLLPSADPTPDWQMFRDLLRKATPAQIAQAKDVLAGGSASAPRRAPFCGIALIGLRGAGKSTLGKILAKKVGWSFVELNKEVEQQNGLSVAEIIALYGQEGFRRMEQAALQQLLARNELMVLATGGGIVSEPLTFDQILSSFYTIWLKAEPEEHMARVRRQGDLRPMADDRSAMAELRNILLSREPLYSRATAVVDTAGLSVDAAAARLIDAVRPVLQNEARSFGLRSVAL
The following text describes a protein:
Function:
Small heat shock protein required for the establishment of auxin gradients and for patterning of the apical domain of the embryo. Involved in the specification of the cotyledon primordia. Also required for normal inflorescence and floral meristem function, normal developmental patterning and thermotolerance. Acts as a molecular chaperone.
Subcellular Localization:
Cytoplasm.
Sequence:
MAIISEYEEEEEDSEERPAVVGVINMQDEEEDGYEDEDEDNDEDYNPDPYFSSQPVYATNSMRPFDEVLRYLLQEHQQQPLDLLSTVIEYLFRKTGIAMQEGVDARVSEMLFAAKRMRVDGDDIEDVFAGPDKVAKLDEIFDDPGTKEEDSPHVSVSESTKGLQGSVSSTSESSKKQGSAVEDEETVIITPTEYLQKDMCEDPEVAVFVANNSGLYHQTDTNHDTKTDMKSETEITTLSEVEPVTNNWLAGEPGNIEIHCKGKKKGLEKGEKPQDLDPNSGNGADLGHYSWTQTLTDTALIFPVPAGTKAKSVVCEIQPRYLKIGLKGEIPLLEGDLNKPVKPSECFWNLEDGKLLTIHLQKWYTMDWWHVVVEGEPEIDVEKLQLPQASLSDLHPDTRQHIEHTLFEQKQAAMGVTDSGEERKADALRKFMGEVLLCHPLVHNFHIQFWDILMRSPMQASRSRLNVINTET
The following text describes a protein:
Function:
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDTILTLSYFVIFSMLGYLTRSGIQGLNTYPGAPFHGLVWAQVCGCAFMGFLQTENVMFPTDSTNKPLLLALTTGYCGSVTTFSSWMLEMFLGMGNIEPSYTRAKGDGFLSLVSIFSITLLMAFAALLYGKRVGSTTHLWTIKSHRLLRPFPAKTHTAVRIFLSLLAVCFYVGAALYTAFSTSYAHRKFGFGLVFSPIGALLRLYLSLWLNKSSAYLPWGTFAANILGTLILSIMFMIPRICHVSDISRSVLYGVQNGFCGALTTLSTFLNELHKLPDKKAYIYGALSVFVGYALVLIVDGSTAWGHGYTVEYL
The following text describes a protein:
Function:
Participates in both transcription termination and antitermination.
Subcellular Localization:
Cytoplasm.
Sequence:
MKITFISGQEVSLGTSFLLFSKKIVMNELNQPLLAIIKNVAKTKNLSIEEVVFCLKTALEQAYKKHLNFVNVEVNINFDKGIINVEQLFNVVSDENEDYDDFLEIPLQAANKINSSLQLGDVLRKPIPLKNISSDLINKMIAIFNQKISETNFKAVMSEFSSEVGEVIEAKVEDIDTNKEGGLKGYIINLETTKGYISKRELSKGERLEIGKKYLFVIKEIQRQASLWPITLSRSDTRLLQFLLTSNTPEIENGTIVIKKIERSPGVKSKIAVISNDPAVDPVAAILGPKGEKIRGISEEFNGEIIDIVFWNEDKLKFLINAILPAEVIGYNILQDDERDTSIEVVVPANQIANVFGFKGVNIRLISNLTGWNSVDVYSEKDASEANIKFTRLSFEPEGLFGIKKRREKIISNDATDKVFYTSKDNVIDDEIIVDLAKDLMVDNKQKQPEQVAKQVVEKSQLEKQVTPKEKEKVQPKAKVHSNSHSKKPAKPNQIFSITVDASDKNLKKDQVDNNQTNPQTKQTFDSFDDL
The following text describes a protein:
Function:
Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Localizes to the sporulation septum and to the second division site within the mother cell. Before the start of engulfment localizes to the septal midpoint, then spreads throughout the septum prior to becoming enriched at the leading edge of the engulfing membrane, where it remains until the completion of membrane migration. Some remain partially trapped at the septum during engulfment and upon completion of engulfment become dispersed in the outer forespore membrane. Localization of the MPD complex to the septal membrane is dependent on SpoIIB.
Sequence:
MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTISQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFIMIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLIRQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF
The following text describes a protein:
Function:
Involved in the biosynthesis of phylloquinone (vitamin K1). Methyltransferase required for the conversion of 2-phytyl-1,4-beta-naphthoquinol to phylloquinol.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASSLHFPVLCLHGGCLNRDRRTRGATRCSSERQALFGRIAPVYDNLNDLLSLGQHRIWKRMAVSWSGAKMGDCVLDLCCGSGDLAFLLSEIVGPHGRVTGLDFSKEQLSVASSRQRSRAKACYKNIEWVEGNALELPFPGSYFDAITIGYGLRNVVDKPKAMREMCRVVKRGCRICVLDFNKSTQPSTTSFQEWMIDNIVVPVATGYGLGKDYEYLKSSINEFLTGKELEKLALESGFSNGKHYEISGGLMGILVATR
The following text describes a protein:
Function:
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
Sequence:
MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS
The following text describes a protein:
Function:
Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.
Sequence:
MLTPRGRSMSRRHRPFHPDHDDSEIESRSTVISRKSDAYQAALGWLVDRIDYEKLASSGSRYRFTLDRMRDLIQRLGHGQHLTVDSTELGQSPPSSENQSSVVELARPDSIVQPSKSTGVQIVHLAGTKGKGSAATMVAALLHSAGYRVGLYTSPHLVNLEERFRVDGEIATPEEMIGLIDSMRPIVEAMTAAPIGGPSFFELTTAMAIEHFHRRQCDIWVLETGLGGRLDSTNVFQSHATAITSIGLDHQHVLGDTAELIAAEKAGIFKRDTPAINGVPAGPVRDVIVRIANQIGAPLMHLGDEIQITPNTESQKCWGSSFQISGLGDWMPGDTVVDLKLEGAHQIRNAAIALALVDALPDVTRKLRPEQCIHQCLSSLQMEARLERFDLSDDRVVLLDTAHNADSIEAMLNVLNQRMAGRRRLCLFGTSADKNVLAMLQRMQPHFDQWTLTRYEGNPRFVPVDDLNRTALQAGLSPDRITSFEHPIAAVQNAVNSLNTGDVLVICGSFFLAAEIRPWLVQCCGSSSVSTTSSSSTDGSSSG
The following text describes a protein:
Function:
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
Subcellular Localization:
Cytoplasm.
Sequence:
MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGDLLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADMKRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQSEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKNSVIGDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK
The following text describes a protein:
Function:
Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
Sequence:
MTFEIVFDSAREFESLIATLEKFFDEAVFQVNMEGIQMRAIDPSRVVLVDLNLPEMLFSKYSVESEEAIAFDLKRFLKVLKLARSRDTLVLRKGGENFLEVGLLGDENTWFKLPLIDANTPEIEIPSLPWTVKAVVLAGALKRAVKAAKLVSDSIYFMATPEKLTFKAEGNDSEVRTVLTMEDPGLLDLEHKMTKAKSAYGVAYLEDILRSLADADEVIIRFGFDIPLLLKYMVRDAGEVSFLIAPRVEEGRS
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MTSVHGSSVHEAFALMATLLAPRVPIRYLEMSGKLLQRRQMEEVFEERAAAERCGFPACENPLPKSAGKFRVSLARKEIYDAHYERQFCSQLCLKLVPSLVEVFGTDKPNPSDYEDDDKQPKKHVETPVGHKPEPLPKSKAVWSKTHDLGVVERKHSTANAMSVGVPPALEAKTSSQLKENEAPAPPDRNFPTTEHAMLIEGYVFPAHKQKLAKKVEKLVKKSQEKDDDEDDIVVSDSDESDAAASDVSSGGSFDISDFDDEEVVTLNDLPLFSHLWGLFSNWITHETTLVVAGLSLPAKEEEKEEDDPFLAGPEKAEADAARRRARQMRVERWNSLSLMLRRPLPQVALKLKLASDRFSNHRIDIITETFTLRDAIDTRNAQQWTCVATILMLVAYGIKPGDLAGGDRSEQVKALTKLDTSELQQLLNLFYEVRKDSDVAVDTDVAPVPEDDSSMKDAAKEGSADNKPPTICS
The following text describes a protein:
Function:
The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.
Sequence:
MSNLSIADGIRLGIAVGVAKTVTAVVKALRLGSASVLPGEIARRLHPKMLGLLAQQVSQGVILVVGTNGKTTTSLLLRKILVDQGYRVTHNATGANLINGLITALLADANLFGRLSTDFAILEVDENVLPLVLKDCQPRAILALNLFRDQLDRYGEVDSISQRWQKAIAPLPENTIVAVNADDPTLSHLGQKLAQRVCYFGLSEPDLYLEEIPHAVDSIYCPQCGTSLDYRGVYLSHLGDYQCPSCGFQKSQPAFHSSKWPQILIGVYNKYNTLAAGLVAQQLGVNTENIFNNIRSFKAAFGRAEELNVEGKHVRILLSKNPVGLNETIRAVNDLKLQGQCSTTLLVLNDRIADGTDVSWIWDVDTEPLVASGGTFVVSGDRLYDMALRLQYSQENLIQPSQGEEPWDGHTSRLILEENLEKAVQIALELTPAEETLHIIPTYTAMLEVRGILTGRKIL
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MASETASASQWVSPSSRPQHIEQLISGVDRYNPQNLDVLHDYLAQQLDDGSYDLLANLAILKLYQFNPADFNYVVVINILLKALVAAPLPDFNLCISLLGEAPLPTVPVKAEKEATTTDADNAGSLSGDDDDDEVVEKPKDVASAGHLTDPLIVRLSQLSTLLFQARFREFWSTLASESYSDVRDYAAKISEFENAARRVALNSVKGSFTSISEKRIANYLNLSGSQLAEFINAQDGWKLADGTVSVPANPDNEIKATVIREEISLDQMHKFLAQAQSPLLRA
The following text describes a protein:
Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
Sequence:
MPELPEVETTLRGIAPHIEGKTVEAVVLRQLKLRWQINPDLGEILSGRQVLSCGRRAKYLLIRFQTGVLLIHLGMSGSLRIFTPSDGRIGRPDRHDHVDIVFSDGTVMRYRDPRKFGAILWYEGIEEHHPLLEKLGPEPLSEAFCADYLYARLKAQKRAVKLALMDNAVVVGVGNIYANESLFRAGISPHRPANRLKKKECALLVETVKAVLQRAIETGGSTLRDFVDSDGKSGYFQQEYTVYGRHNQPCPRCGGLVVKETLGQRGTFYCPNCQK
The following text describes a protein:
Function:
Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis.
Sequence:
MEGPAGYLRRASLAQLTQELGTAFFQRQQLPAAMADSFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAVESFAGSPLIYRPVAIALDTKGPEIRTGIPQGGPTSEVELVKGSRVLVTVDPAFQKLGNATTVWVDYPNIIRVVPVGGRIYIDDGLISLVVTKIGPEGLETQVESGGVLGSRKGVNLPGTQVDLPGLSEQDIQDLQFGVEHGVDIIFASFVRKASDVAAVRAALGPEGQGIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGHFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQAHLCRGVFPVLYREPPEDIWADDVDRRVQFGIESGKLRGFLRLGDLVIVVTGWRPGSGYTNIMRVLSIT
The following text describes a protein:
Function:
Negative regulator of the abscisic acid (ABA) signaling pathway involved in seed germination and in responses to stress conditions. Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MCVLKVANQEDNVGKKAESIRDDDHRTLSEIDQWLYLFAAEDDHHRHSFPTQQPPPSSSSSSLISGFSREMEMSAIVSALTHVVAGNVPQHQQGGGEGSGEGTSNSSSSSGQKRRREVEEGGAKAVKAANTLTVDQYFSGGSSTSKVREASSNMSGPGPTYEYTTTATASSETSSFSGDQPRRRYRGVRQRPWGKWAAEIRDPFKAARVWLGTFDNAESAARAYDEAALRFRGNKAKLNFPENVKLVRPASTEAQPVHQTAAQRPTQSRNSGSTTTLLPIRPASNQSVHSQPLMQSYNLSYSEMARQQQQFQQHHQQSLDLYDQMSFPLRFGHTGGSMMQSTSSSSSHSRPLFSPAAVQPPPESASETGYLQDIQWPSDKTSNNYNNSPSS
The following text describes a protein:
Function:
Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail.
Sequence:
MAEDKTKPSELDQGKYDADDNVKIICLGDSAVGKSKLMERFLMDGFQPQQLSTYALTLYKHTATVDGKTILVDFWDTAGQERFQSMHASYYHKAHACIMVFDIQRKVTYRNLSTWYTELREFRPEIPCIVVANKIDDINVTQKSFNFAKKFSLPLYFVSAADGTNVVKLFNDAIRLAVSYKQNSQDFMDEIFQELENFSLEQEEEDVPDQEQSSSIETPSEEVASPHS
The following text describes a protein:
Function:
ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVWVGIDDTDSSRGMCTTYLAVLAMERVERELGKVIGFPRLIRLNPTIPYKTRGNGAVSFLVEVDDVGELVDVVNEVIIEHAMLDDEKTNPGAVFVDEELAVKLKPFADKAIKDVLQIDEALFVIGKYFIPHLRHKKGRGLIGALAAVGAELEDFTLELIAYRYPERFGTEREYDEESFFDMDYELYPQTFDNVDWCNDVVVCIPNTPCPVLYGIRGESVEALYKAMESVKTEPVDRRMIFVTNHATDMHLIGEEEVHRLENYRSYRLRGRVTLEPYDIEGGHVFFEIDTKFGSVKCAAFEPTKQFRNVIRLLRKGDVVEVYGSMKKDTINLEKIQIVELAEIWVEKNPICPSCGRRMESAGRGQGFRCKKCRTKADEKLREKVERELQPGFYEVPPSARRHLSKPLIRMNVEGRHIFR
The following text describes a protein:
Function:
Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MSPPRRVSFPPDTLQEDPPLADSPLSSPKLPEYDRQSSSTPIVSSNLPTDTTNSASAGPRRRQQPSRQVTLDASPPSATRRETTESARTQRSRAGSRRTSNSLDPNPGLMRRVTTVLFTPPKKIGKAPTYWGSMKAAITSTWLNVLLVFIPIGWALYLAKHNGGKDSISDTAVFCCTFIAIIPLAGLLGFATEEAALRLGQTLGGLLNATLGNAVELIVAILALIKCELQVVQSSLVGSILSNILLVLGMCFFAGGVRFAEQAIKSTAAQLNASLLLIAVIAVLIPSAFHFSISSSTSNTDASELANGEGADLLSMSHAVSILLLILYLGYLLFQMWTHATYYVDDAVTGSTQYPEAITNVSEKLKFRNFHRRKHDEEESYSTATTVSDAAVPPSARAEGGEVPATHGPGTAAAETGNRVEHEDAEEEEEEETPQMNVVCTIALMVIDTVLVGVTAEFLVDSINGMVESNPSLSAEWVGLILLPIVGNAAEHFTAVSVSVKDKLDLSISVAVGSSIQIALFVIPVIELLAWTIGKPMTLLFDPYESIVLFLSVLIVNQTLADGRSNWMEGMVLMMLYIIIAVSFWYYPGSTTATLLGCQDSSSVTG
The following text describes a protein:
Function:
Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.
Sequence:
MSFHQNKYDRQLRLWEAAGQSKIENASCCLLYVNNVGCECLKNLILPGIGKICILDDRLVDKSVDAPNFFLDEEDHNKSKVECLAENLSRLNPDVCIESKKANPLDIISSDIDFFHSFNVVILADMLPKIQLIKLTNYLWNKQIAFLQLRSIGFNGSIRVCLPDCTILQTQNDASLDLRLNMPWAELKEYSKQLFERESKDRHGDIPFVAILVHGCSQLETGNKGNPSSQRKDILRNWIKTQMLYADEENFEEALSNCWRPFQSTNISSALKTIFDDINCQNLNEQSSSFWIIMNAICKFVECYHCIPVSGILPDMKAGSSEFVSLQRVYQQKAKEDALKVKNYVQKNLKLLSRPIDSITDDEIFQFCKNASQARYIKYRKIEEELNSPLLTDLASDNESLVPWYFAFRCFDIYKERYNSSPDASLTSSIHKYEEIACEFMKSLGQSPTQSVCNACREISRSAGAEIHSVSAFIGAIAAQEAIKFLTRQYIPLNNTCLVDAAHARTESFSF