lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity). Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Due to intron retention.
Subcellular Localization:
Nucleus. Nucleus, PML body. Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-210 phosphorylation, to PML bodies for subsequent sumoylation.
Sequence:
MATIEEIAHQIIDQQMGEIVTEQQTGQKIQIVTALDHSTQGKQFILANHEGSTPGKVFLTTPDAAGVNQLFFTSPDLSAPHLQLLTEKSPDQGPNKVFDLCVVCGDKASGRHYGAITCEGCKGFFKRSIRKNLVYSCRGSKDCVINKHHRNRCQYCRLQRCIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLAATPTFVTDSETARSAGLLDSGMFVNIHPSGIKTEPAMLMAPDKAESCQGDLSTLASVVTSLANLGKAKDLSHCGGDMPVVQSLRNGDTSFGAFHHDIQTNGDVSRAFDTLAKALTPGESSACQSPEEGMEGSPHLIAGEPSFVEKEGPLLSESHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHSSLQQDKMSPERRKSLMEHIFKLQEFCNSMVKLCIDGHEYAYLKAIVLFSPDHPGLENMELIERFQEKAYVEFQDYITRTYPDDTYRLSRLLLRLPALRLMNATITEELFFKGLIGNVRIDSVIPHILKMEPADYNSQIIGHSL
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein.
Sequence:
MATRSTRRLLRTTLCPSQLHTSLRTTLYTVRYLRTSSALHEQLSPQSPLKVFLDTFKSEVKKSKELETSVKALQDSSGHLGESEAFKKAKDALEKASIARTKTAAALGTGLHKTWESAPVRMSRKAVSGTTHWFFRMFDIIMKPITGTRLYQSIRDSMVDGASSRYGFYGTKEERRKARALLEMQERLNPKSIRYEPNTEETRVVLHNKLTIRDRIRMYKNQSKLFRKWEDFKIYYQETEHPILSSVRDMADSISSFWYRMFSETEASQVVSRFKEIDPSFNSEVFQRYLREYIIPEVSEAYVKGDKEALRTWFSEAPFSVWETTTKEYAKHGVVSAGQVLDIRGVDIASYRMLQPNNIPVMVITFRTQEVHLFKNAKSGEVVAGRNDRIQQCTYAIVMTRLEEQLDNKETKGWCIVDFARARAVDYN
The following text describes a protein:
Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLRCLISRPQLLPTRLPLATPSCVSRRTFLGFTGGDTKEQRYILKRVFNAPLHYVYPAVSEVSLYKLFIPYCTDSFVNKRRPGDNMPTEAGLRVGFQQYDETFVCRVDCTTLPGNQRSVVAESLAHHLFETLHTQWLLSPHPTRPDASVVELILRFKFKSQLYNSVSSIFGTRVTQVVMKAFEKRVFQLRKEAMDRPPTGDAGH
The following text describes a protein:
Function:
Serine protease inhibitor, which acrs as a regulator of the classical complement pathway. Forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May also regulate blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
Subcellular Localization:
Secreted.
Sequence:
MASKLTPLTLLLLLLAGDRAFSDSEVTSHSSQDPLVVQEGSRDSVPERDGSRSPIEHTGQSSTWPTTSGSTKISNDTMDQVANESFIQHVQPAAQLPEDSPSQSPVNSSSPPSTASAPPTQAPTEPLCPEPLAWCSDSDRDSSEATLSEALTDFSVKLYHAFSATKKAETNMAFSPFSIASLLTQVLLGAGDSTKSNLEDILSYPKDFACVHQTLKAFSSKGVTSVSQIFHSPDLAIRDTYVNASLSLYGSSPRVLGPDGDANLKLINTWVAENTNHKINELLDSLPSDTRLVLLNAVYLSAKWKKTFEQKKMMASFLYKNSMIKVPMLSSKKYPLALFNDQTLKAKVGQLQLSHNLSFVIMVPQSPTHQLEDMEKALNPTVFKAILKKLELSKFQPTYVMMPRIKVKSSQDMLSIMEKLEFFDFTYDLNLCGLTEDPDLQVSSMKHETVLELTETGVEAAAASTISVARNLLIFEVQQPFLFLLWDQRHKFPVFMGRVYDPRA
The following text describes a protein:
Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
Sequence:
MPNSGPSAEKRKEGGGKGGGKGGRGRERKPPSREVTVSKALSLLLRHAAEREGLKIDSQGYANVADVLAWRKLKSLKVTFPEIISAVETSDKKRFALLYQPPSEQTDTLPTKVEEPASAQDEPITATSTGTATATTAALAASKTDQTPAHYLIRATQGHSIKTVEAESGLLERLTLDNPDKLPETVVHGTYHSTWPLILESGGVKCMGRNHAHFATGPAVQDVLSAIDSSVSRGEEGDEKSGSGAGSHGMVISGMRADAAVLIYIDIRRALAGGCPFWRSENGVILSEGMEVNVATGTGTEKGVIPVEYFDVVVERRKGLGKIWEGGKVIQSLPEELTKKGNPKRRGGGE
The following text describes a protein:
Function:
Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation (By similarity).
Subcellular Localization:
Nucleus.
Domain:
In contrast to classical members of the E2F transcription factor, atypical members contain 2 DNA-binding domains and regulate transcription in a DP-independent manner. Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (By similarity).
Sequence:
MEVNCLTLKDLISRPPRLDFAIEDGENAQKENIFVDLSRMAPKTPIKNEPIDLSKQKIFTPERNPITPVKLVDRQQVEPWTPTANLKILISAASPDIRDREKKKELFRPIENKDDVFTDSLQLDAVDDSAVDEFEKQRPSRKQKSLGLLCQKFLARYPSYPLSTEKTTISLDEVAVSLGVERRRIYDIVNVLESLHLVSRVAKNQYSWHGRHSLPKTLRNLQRLGEKQKYEEQMAHLQQKELNPIDHKSGERRRDGCPDSQDPQLLDFPEPDCPSSSANSRKDKSLKIMSQKFVMLFLVSKTKIVTLDVAAKILIEESQDIPDHSKFKTKVRRLYDIANVLTSLMLIKKVHVTEDRGRKPAFKWIGPVDFSSTDDDLVDVSTPVLPELKKEIYGHVQFCAKQKLARHSSFNSEQASERTQRKVNSEPSSPYRQKQGLGVYSLEIGSLAAVSRQKMEDNSETVAFASQNMMPLPSSLDPAAPLPSPSVDSEYRVSPLCHQALSAAQTDLKALPAQNGLNGQGGVSLASMALDVEHQPQPLAAAQPLLYVPPAPLFMLCGGLQEGLSPGSGSGSGSVGGGSEVTAAEQPPMPSGQKRLSKERRLQEEEEEPATKRQCRDHEDGPLSLVMPKKPSDSADIASPKTSENRASAPHEDTHMNGQLSAAKAVSGKATTNGFVSSEWGNPCSNTEIEKPSEENESTKGPSPLQYLYVQPPAGLNGLSVLLPSSQSPHAVGLPVGPLPSLSIQYMVLPSPALSGFPVLCSPTMPGPVSSAPSPLPNVGPVNFGLPGLGSTAHLLIGPAAMVNPKSSTLPSTDPQLQGPCSLHLSPVMSRSHGSVQPGSPAYGSLPAATVKLQQSPVPVTPKSIRCTHQETFFKTPGSLGDPVLRRKERNQSRSSSSAQRRLEISSGGTD
The following text describes a protein:
Function:
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably involved in the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTTKEVKIQYKKFIGRKIFFTFFLLASIILVAGISASLGSANLSLGETYSAVLHRFLPAYFASSSLADVCIWNLRLPRIFMGIVAGFGLGVAGCVTQAILKNPLASPYTLGISSGAGFGASLAILTGSGIIGGDYLVIGNAFLFALLCSFIILGLSNRKDATPETMILAGIAMMYLFSAMTTILQYFGEAEAVKEAIFWAVGDLGRSSWPKVSIITITLACCVFLLMIKSLDLNIMAAGDETAASLGVNVKGTRILLMAVTTLLVACIVCFTGTIGFIGLVAPHLTRIAIGGDNRFVLPVSGLFGALLLISADLVARRVLAPIILPVGAITAFMGAPLFLYMIMKRKREYW
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSSSKHARLLFKAFQKPPQIRCFRAPSSSAPINEKSVFSTKLSGTEFLSPLSKRWTAFSLHRAVPQVSSISNLNSFTHFSSAASPDVSDKTGSPEYSAAEPSRTSTAEGTSESVQHAERSNDIKADDLARMVAERDALLQEKDKTIKELQDKVLRGYAEVENVMARARREAESTRKFALQGFAKGLLDVADNLGRATGAVPENLRKLDSTLEDSSGAAKVLITLLQGVEMTEKQLQQVFRQNGLEKFESEGKEFDPNYHSAMFELEDETKTPGTVAIVTKVGYLLHDRVIRPAEVGVIKAKE
The following text describes a protein:
Function:
Involved in the sexual differentiation process. Modulate the ability of the cell to differentiate in response to the nitrogen starvation signal; in particular in response to decreases in the level of cellular cAMP.
Subcellular Localization:
Nucleus.
Sequence:
MSSYALPSMQPTPTSSIPLRQMSQPTTSAPSNSASSTPYSPQQVPLTHNSYPLSTPSSFQHGQTRLPPINCLAEPFNRPQPWHSNSAAPASSSPTSATLSTAAHPVHTNAAQVAGSSSSYVYSVPPTNSTTSQASAKHSAVPHRSSQFQSTTLTPSTTDSSSTDVSSSDSVSTSASSSNASNTVSVTSPASSSATPLPNQPSQQQFLVSKNDAFTTFVHSVHNTPMQQSMYVPQQQTSHSSGASYQNESANPPVQSPMQYSYSQGQPFSYPQHKNQSFSASPIDPSMSYVYRAPESFSSINANVPYGRNEYLRRVTSLVPNQPEYTGPYTRNPELRTSHKLAERKRRKEIKELFDDLKDALPLDKSTKSSKWGLLTRAIQYIEQLKSEQVALEAYVKSLEENMQSNKEVTKGT
The following text describes a protein:
Function:
Probable lipase.
Subcellular Localization:
Golgi apparatus. Membrane; Single-pass type II membrane protein.
Sequence:
MTLNGNIMKYCLEKGEILISFLLIALESMFRICTVILPSPLRNWFYEQSKKVYSYFLPELLVDDNANKLTDARDTIDLCALHGYDLEEHFVRTTDGYLLGLHRVYKKKKGKIEELNYLPPVLFIHGLMMNSESWVCNLKKEDAIPFALVEQGYDVWLGNLRGNKYSIKNIKFSSQNPKFWDFSLDSIAIFDIPSIVKYILSVNSFDSISLVGFSQGAILAFAALSIDTELRNSVRAFIALAPAIAPKKYSGRTVKSIIHANSQLLYLMFGRNSMLGSAVFWQAVLYPPVFAKIVDLFLRFFLSWTGKNISETQKIVAYSHLYSFTSVKCFVHWAQITRRKVLQMYDDSPGFKPSYYTNLNRIARYPIENIRLPITLVYGSNDNMVDIETLKTQLPPLSQCIQIPNYEHLDIIMGDTKKDIVIQQVVEQLNHVIAGDYFESIKEEFGLDTELVDGVMNHTI
The following text describes a protein:
Function:
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAMVQGKSLKYRVWATHAALWVFLALIIFPLLMIVAISFREGNFATGSLIPDRPSLEHWKLALGIAVQNADGSVTPPPFPVMTWLWNSVKVAGITSVLIVALSTTSAYAFARMRFKGKETILKAMMIFQMFPAVLALVALYALFDKLGQYIPFLGLNTHGGLIFSYLGGIALHVWTIKGYFETIDRSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIGVVGEVPVASLLLSDVNSYTLAVGMQQYLYPQNYLWGDFAAAAVLSALPITIVFLLAQRWLVGGLTAGGVKG
The following text describes a protein:
Function:
Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MNDQMKQRWKEAKERIGNAYHDYGRLCAAHPKTCLTMSLLTMIVLSYPTITRLRLPVSTPIDIFWSEHLHVNEKIAPFWINENPASYIQQFIVSTTVSPWNATEMSPELAVRAAVATSFRIRALLLAEPSVEELCLRLAGQRQDSTWPFRSKSLCVVLSPATIWYNNAQKFQEDDNVIETVFNEQCKTTFCMRDLLLGAPVAATGIKQKYQTNRKRKIEFAVTVFFSRYSKRVIQTLRDKLGKEFKLVQTPSNDEHTFVQVYFHPLKTFSSYLPLISTYFVCMLYVYYSSRKIQMVASRWGLAFASCFTVASTLLMTTGICAHLDLSTTTWGSEIYPYIALIMGLENTLCITRSVVYTSPSLDVSSRIAHGLSQEGYKLTKYYILELLFLLIGFLTRVPDIQEFCQFSVICVTVDFYMQLFFYAPCLTFDLQRLGLEEKRKFAEILLYEEIPRLKNYAPISCPMRKIWPKLFVMKKMQKRRFSDSELFQDDDAPIGSAHFSASKDDGDVPIPRPEDSLRMKIMYFITRTRIVQRTILVVFATWTLILVFFVGSRQLGIDNRLTNQSIESISQSHRILSTANLQYGNWQRRTYKWWPAVAHEYNISLNSRYVTFLPPIVLQSIIDPTDRFLQKIDKSISNHSENSEEDAPILRSRIDWLEMQLKVYLAAFWLLLITTVIAFFAYVFLSDRWKIGGAKQVQIQQESQKIGADVVMEEEMGGGGRRDKNFVETLPIAFQGHRFPIESVAIDESNPSRFVSSCQEGIVNLWNSQTGQRILRINRLRALPEKGKDIPQAPKVWALAKRNDTVILGCCDGSIEIASVSRNKLIGLYTKSIIGVSHVVCRDDDVAIVRLDGSIDFLTVDYEKTDDGKIRVRQIDHLKSVRAHQKPISRVATWNSSQLITSSFDRSIKMWNWSKKGEDIEMSNVFLAHNAPVVSLVIGERSIIDNQSIMYSSCEEGVICWWNLTTGELIRTLDNNTTWAFQLATSSEFLLGFYGSSQLFMWNVENGQLACRVTDALGDGTSEDTLYTVGSSGVVSFDDQIAATASSDSVTFWDLKHRAIIGKAKLNGKISSMRKLTAQSVLCGVDNSMYAVTVPLVRFKS
The following text describes a protein:
Function:
Acylhydrolase that catalyzes the hydrolysis of phospholipids at the sn-1 position.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MDPLLRSELIRYGELAQACYDAFDYDLASRYCGSCKYPRRAFFERLGMPDAARGYSVTRYLYATSNFRFPNFFSGRSRADAKLWSQRANWIGYVAVSTDEESARLGRRDIAIAWRGTITRLEWVSDLMDYLRPVADEGIPCPDPEVKVESGFVDLYTDKDPSCRFCKYSAREQVLVEVRKLVAHHTALGEDVSISVTGHSLGSSLAILSAYDIAESAANLSNGSNRAAVCVYSFSWPRVGNGRFRQRFEGELGVKALWVTNVHDNVPRMEGIFLNVGVPEMVRRVAEGLRMPWCYSHVGVELALDHKRSPFLKDTLDPGCSHNLEAHLHLLDGYHGSGGRFVLASGRDPALVNKASDFLKDHHCVPPYWRQDENKGMVRASDGRWIQPDRRGHLHDDHHHDGHHVVDGDHHGHFRHFRQP
The following text describes a protein:
Function:
Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MNHAPHLYFAWQQLVEKSQLMLRLATEEQWDELIASEMAYVNAVQEIAHLTEEVDPSTTMQEQLRPMLRLILDNESKVKQLLQIRMDELAKLVGQSSVQKSVLSAYGDQGGFVLAPQDNLF
The following text describes a protein:
Function:
Probable GTP-binding protein that may be involved in cell development.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MIKNYGDRYHLIDKKALEDKKLDKDQLVEFVRTSGISDIGKNYNIVSIIGSQSTGKSTLLNQLFGTKFDVQNRQQSVGQTTVGIWLSKDVQNNVVVLDVEGSDSVERKSGENMVENQTALMALAMSHCFIINVFLNALGQHTSCQLSIIKIIMQQNLKLFQQDTVKHIIFVVRDWDEDANYEEASRRLNGYLLNIWNEIPKPDHYKETDFHQLFSVQVVTLVYYKMKKEFIEQTNDLHAKLSNQQDPNFIFKDFDYEKNVRWSDMPQYLSNIWEVISNNKDLNLPNEKILISNMRCQQIKLEALDGVKQLNEDLQNRVRTKLVDNFAQECQTIMNLAFKLYDKDARDYHIEVYKEKEKELKDELVNRFYTYFQKQTEQLKQHYMNTLTENLETLKRESIYNLPDKLNELDLFKLQFEEQLAKSVIQKGLWQEEDHIRYFRQQFDNQLKAFVEAQLATFKQQLDNIIKSECDKIVSSQVLNISSKFWQQIESDYYAMISEKYQKYEVLLTGLRVQQKQIEDYLNKFEEDSFHNLKQVIAVASGRFKDQLFQQFKAQFVRAPDGQPRNWQKLTEEEIFHCYTDARDKVFQLLDSLRIRKIKFIRQQVVLKKKAQTLIISSSQKVQYQISSDADSDDVVLNDVFYTQVKMQLAEDIDVQYQDAIQKHKQDFLQNIPKPFWFLLLFFMYDDVLRWMGNPLFLYPILIILCFVGFCIAIGLHSLPKLAFQWVFRTLNQAVIPIIFGGISKLKGS
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MSLVTLSHVASHLQNASKARLGLTSVPSSNMILTLMLSLQSSGFLSSVTRGGLTPPPMDELSTYEPEAVTQRNISTRRLWLGLKYWNNEPVLSRMSVISKPTKRIWMDVEGLSEIIRGRNANFVEGLRNPGECIYISTSSGIMEARECVERRVGGMLLCRVE
The following text describes a protein:
Function:
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine. Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate. Also has adenosine deaminase activity.
Sequence:
MISITKDKRMLGYESLSSYSNISHFVTTRQGGCSEGNYASFNCTPYSGDEAEKVRRNQTLLMEGMSQIPEELVIPVQTHETNYLLIGDAYLSASSQQRQEMLHGVDALITREPGYCLCISTADCVPVLVYDKKHGAIAAIHAGWRGTVAYIVRDTLLRMEKEFGTSGEDVVACIGPSISLASFEVGEEVYEAFQKNGFDMPRISIRKEETGKHHIDLWEANRMQILAFGVPSGQVELARICTYIHHDEFFSARRLGIKSGRILSGIMIHK
The following text describes a protein:
Function:
May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MSWTQPALLTCLLVLSAITLFDGADSAVSDKRDAVNPQGALRKIFMPEADAASFFKRRSRRAVKTQDEINAEQRQRLAADERRREYHEEQRNKYENYAEEENDEQDERTREKTEQWREFHYDGLDPSYEYNRHTI
The following text describes a protein:
Function:
Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2.
Subcellular Localization:
Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLTDPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNLSGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKSMGFLSIKDTQDEDYFKDILSDNSGHEDSENTCSPYQFKTSGPEKKPIPGIDVLSKKKIWASSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIALDIFGPQKMDPIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDAFSTSSESPSIISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIMLKRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFGPEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHAFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVVVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYVQDSAIDSSSKDHHWSRGTLRHISENSFGLSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDATDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVLVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHREAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLKDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLSKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGNSCGPGTLKMNGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKSQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK
The following text describes a protein:
Function:
Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK). Can use a variety of allylic isoprenyl diphosphates as substrates but has a requirement for at least three isoprene units.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MASFAQWVSGARPRTLPNAIAPVVAGTGAAAWLHAAVWWKALLALAVAVALVIGVNYANDYSDGIRGTDDDRVGPVRLVGSRLATPRSVLTAAMTSLALGALAGLVLALLSAPWLIAVGAICIAGAWLYTGGSKPYGYAGFGELAVFVFFGPVAVLGTQYTQALRVDWVGLAQAVATGALSCSVLVANNLRDIPTDARADKITLAVRLGDARTRMLYQGLLAVAGVLTFVLMLATPWCVVGLVAAPLALRAAGPVRSGRGGRELIPVLRDTGLAMLVWALAVAGALAFGQLS
The following text describes a protein:
Function:
Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration.
Subcellular Localization:
Cell projection, lamellipodium. Cell junction, focal adhesion.
Sequence:
MKNKGAKQKLKRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDENRPIMKSLTLPALSLPMKLVSLEEAQARSLATNHPARKERRENSLPEIVPPMGTLFHTVLELPDNKRKLSSKSKKWKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVEKATIRPAKSMDSLCSVPVEGKETKGNFNRTVTTGGFFIPATKMHSTGTGSSCDLTKQEGEWGQEGMPPGAEGGFDVSSDRSHLQGAQARPPPEQLKVFRPVEDPESEQTAPKMLGMFYTSNDSPSKSVFTSSLFQMEPSPRNQRKALNISEPFAVSVPLRVSAVISTNSTPCRTPPKELQSLSSLEEFSFHGSESGGWPEEEKPLGAETSAASVPKKAGLEDAKAVPEAPGTVECSKGLSQEPGAHLEEKKTPESSLSSQHLNELEKRPNPEKVVEEGREAGEMESSTLQESPRARAEAVLLHEMDEDDLANALIWPEIQQELKIIESEEELSSLPPPALKTSPIQPILESSLGPFIPSEPPGSLPCGSFPAPVSTPLEVWTRDPANQSTQGASTAASREKPEPEQGLHPDLASLAPLEIVPFEKASPQATVEVGGPGNLSPPLPPAPPPPTPLEESTPVLLSKGGPEREDSSRKLRTDLYIDQLKSQDSPEISSLCQGEEATPRHSDKQNSKNAASEGKGCGFPSPTREVEIVSQEEEDVTHSVQEPSDCDEDDTVTDIAQHGLEMVEPWEEPQWVTSPLHSPTLKDAHKAQVQGLQGHQLEKRLSHRPSLRQSHSLDSKPTVKSQWTLEVPSSSSCANLETERNSDPLQPQAPRREITGWDEKALRSFREFSGLKGAEAPPNQKGPSGVQPNPAETSPISLAEGKELGTHLGHSSPQIRQGGVPGPESSKESSPSVQDSTSPGEHPAKLQLKSTECGPPKGKNRPSSLNLDPAIPIADLFWFENVASFSSPGMQVSEPGDPKVTWMTSSYCKADPWRVYSQDPQDLDIVAHALTGRRNSAPVSVSAVRTSFMVKMCQARAVPVIPPKIQYTQIPQPLPSQSSGENGVQPLERSQEGPSSTSGTTQKPAKDDSPSSLESSKEEKPKQDPGAIKSSPVDATAPCMCEGPTLSPEPGSSNLLSTQDAVVQCRKRMSETEPSGDNLLSSKLERPSGGSKPFHRSRPGRPQSLILFSPPFPIMDHLPPSSTVTDSKVLLSPIRSPTQTVSPGLLCGELAENTWVTPEGVTLRNKMTIPKNGQRLETSTSCFYQPQRRSVILDGRSGRQIE
The following text describes a protein:
Function:
Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
Sequence:
MISEIMHPTKLLKGTKSKLLENKKILVAVTSSIAAIETPKLMRELIRHGAEVYCIITEETKKIIGKEALKFGCGNEVYEEITGDIEHILLYNECDCLLIYPATANIISKINLGIADNIVNTTALMFFGNKPIFIVPAMHENMFNAIKRHIDKLKEKDKIYIISPKFEEGKAKVANIEDVVKAVIEKIGNNLKKEGNRVLILNGGTVEFIDKVRVISNLSSGKMGVALAEAFCKEGFYVEVITAMGLEPPYYIKNHKVLTAKEMLNKAIELAKDFDIIISSAAISDFTVESFEGKLSSEEELILKLKRNPKVLEELRRIYKDKVIIGFKAEYNLDEKELINRAKERLNKYNLNMIIANDLSKHYFGDDYIEVYIITKYEVEKISGSKKEISERIVEKVKKLVKS
The following text describes a protein:
Function:
Structural protein that plays a role in the packaging of nucleocapsids and in their egress from the nucleus toward the cell periphery.
Subcellular Localization:
Host nucleus. Virion. Note=Capsid-associated. Present in both the budded virus (BV) and the occluded virus (OV). The occluded form allows the virus to be transmitted from insect to insect through ingestion of contaminated food while the budded form is responsible for the dissemination of infection throughout the insect host.
Sequence:
MNDSNSLLITRLAAQILSRNMQTVDVIVDDKTLSLEEKIDTLTSMVLAVNSPPQSPPRVTSSDLAASIIKNNSKMVGNDFEMRYNVLRMAVVFVKHYPKYYNETTAGLVAEIESNLLQYQNYVNQGNYQNIEGYDSLLNKAEECYVKIDRLFKESIKKIMDDTEAFEREQEAERLRAEQTAANALLERRAQTSADDVVNRADANIPTAFSDPLPGPSAPRYMYESSESDTYMETARRTAEHYTDQDKDYNAAYTADEYNSLVKTVLLRLIEKALATLKNRLHITTIDQLKKFRDYLNSDADAGEFQIFLNQEDCVILKNLSNLASKFFNVRCVADTLEVMLEALRNNIELVQPESDAVRRIVIKMTQEIKDSSTPLYNIAMYKSDYDAIKNKNIKTLFDLYNDRLPINFLDTSATSPVRKTSGKRSAEDDLLPTRSSKRANRPEINVISSEDEQEDDDVEDVDYEKESKRRKLEDEDFLKLKALEFSKDIVNEKLQKIIVVTDGMKRLYEYCNCKNSLETLPSAANYGSLLKRLNLYNLDHIEMNVNFYELLFPLTLYNDNDNSDKTLSHQLVNYIFLASNYFQNCAKNFNYMRETFNVFGPFKQIDFMVMFVIKFNFLCDMRNFAKLIDELVPNKQPNMRIHSVLVMRDKIVKLAFSNLQFQTFSKKDKSRNTKHLQRLIMLMNANYNVI