lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MNTLHPAPTQRFVYLSINAHSIAFPNYPITCDGNIQSLTVVNLITLLTVLSDIDDMIHSQNSKHSSSLPLSVTTQHTNLSNTIIQQPPLPTSTHSISSGSNLKDQNPSNSNLDGLESKLHHSDHTKTLQSTVTASTNKRDSVSARKVSVLLPTLSKPHSGKPTKQFVSKESSLTKIQKHSPKESTTKSIPTLDSSIEIKQSRTIRDSALQKDPYSNEKSQKRLAESESGSMCVDVRKKKKHKGRKDRRDLSKDALLPAIESIHLVNQNLKRFSCFGDEAGAALEKMKTITLEYPGDGAHEVYGLAVPSRSTQNEHNPIQDIYSTTQMIAQYCISQEHKSLFGDSKSGIIRHIIKACHRRDPNALESAIADYNRVMIRLKDKGVFEQDEIRGPPASCELTTHILEQAYGFSNNVYGEIKHSFVRDIIKHADIQPHHTFLDMGSGIGNVILQVAAECLCECYGIEIMETPSELARKQKQEFLSRMRYYAKPCGRIVVKQGNFLDDAEIHEVISRADVIFVNNYAFDAELNLGIIAKFLDLKESAKVVSLRSFVPVDRRPSLRRSNAIESIFTVKEYHFAKDSVSWMVEGGSYYVHTVDRSQLADFE
The following text describes a protein:
Function:
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
Sequence:
MVTERQQDILNLIIDIFTKTHEPVGSKALQESINSSSATIRNDMAELEKQGLLEKAHTSSGRMPSVAGFQYYVKHSLDFDRLAENEVYEIVKAFDQEFFKLEDILQEAANLLTDLSGCTVVALDVEPSRQRLTAFDIVVLGQHTALAVFTLDESRTVTSQFLIPRNFLQEDLLKLKSIIQERFLGHTVLDIHYKIRTEIPQIIQRYFTTTDNVIDLFEHIFKEMFNENIVMAGKVNLLNFANLAAYQFFDQPQKVALEIREGLREDQMQNVRVADGQESCLADLAVISSKFLIPYRGVGILAIIGPVNLDYQQLINQINVVNRVLTMKLTDFYRYLSSNHYEVH
The following text describes a protein:
Function:
Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand. Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide. Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity.
Subcellular Localization:
Cytoplasm, sarcoplasm.
Sequence:
MADFDMVLKCWGPVEADHATHGSLVLTRLFTEHPETLKLFPKFAGIAHGDLAGDAGVSAHGATVLKKLGDLLKARGGHAALLKPLSSSHATKHKIPIINFKLIAEVIGKVMEEKAGLDAAGQTALRNVMAIIITDMEADYKELGFTE
The following text describes a protein:
Function:
Engrailed (en) and invected (inv) are functionally redundant transcription factors in neuronal precursor cell NB5-3 specification. Inv is unable to substitute for en in other regulatory processes such as maintaining gsb expression in the neuroectoderm after stage 10 of embryogenesis. Maintenance of gsb expression in row 5 of the neuroectoderm involves an as yet unidentified short range signaling molecule.
Subcellular Localization:
Nucleus.
Sequence:
MSTLASTRPPPLKLTIPSLEEAEDHAQERRAGGGGQEVGKMHPDCLPLPLVQPGNSPQVREEEEDEQTECEEQLNIEDEEVEEEHDLDLEDPASCCSENSVLSVGQEQSEAAQAALSAQAQARQRLLISQIYRPSAFSSTATTVLPPSEGPPFSPEDLLQLPPSTGTFQEEFLRKSQLYAEELMKQQMHLMAAARVNALTAAAAGKQLQMAMAAAAVATVPSGQDALAQLTATALGLGPGGAVHPHQQLLLQRDQVHHHHHMQNHLNNNENLHERALKFSIDNILKADFGSRLPKIGALSGNIGGGSVSGSSTGSSKNSGNTNGNRSPLKAPKKSGKPLNLAQSNAAANSSLSFSSSLANICSNSNDSNSTATSSSTTNTSGAPVDLVKSPPPAAGAGATGASGKSGEDSGTPIVWPAWVYCTRYSDRPSSGRSPRARKPKKPATSSSAAGGGGGGVEKGEAADGGGVPEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGLNEAQIKIWFQNKRAKLKKSSGTKNPLALQLMAQGLYNHSTIPLTREEEELQELQEAASAAAAKEPC
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Subcellular Localization:
Nucleus.
Sequence:
MGKQKQQVISRFFAPKPSTPTPSQPQNPPPTTPPKITTTVSFSPAKRRRITQLNSPHSKLPKLTHPPPTDEPNIPLPNPTLHQKFLNKLLEPSQDLLEPSRISNSTQAPNPKYTPLEQQVVELKARYPDVLLMIEVGYKYRFFGEDAENAARVLGIYAHMDHNFLTASVPTVRLHFHVRRLVSAGYKIGVVKQTETAAIKAHGANKVGPFCRGLSALYTKATLEAAEDLGGGTEECSSCNNYLFCVVENGAGDMDSGADVRIGAVAVEISTGDVVYGEFDDNFTRARLEAMVLNLSPAELLLGRALSKQTEKLLLAYAGPASNVRVEHASQDFSRSGGALNEVLSLYESLTESKSAKTRGNYLAFEGIKAMPDLAIQALALTTRHLKQFGFERILCLEASFRLFSNIAEMTLSANALQQLEVLKNNSDGTACGSLLQCMNQTLTTFGSRLLRHWVTHPLCDRNMIHARLDAVSEMIHNVISSVLFTLGRVPDVQRGITRIFHRTATASEFIAVIQAILVAGRQLCKLDVELEDDKKNPQGRTVRSVLLRKSISTASSSSVIKSAASLLSKLNKEAADKQDLQNLFIVSDGSFPEVASARNKVRLANKKLDQLLPLYRKKLRIRNLEYMSVSGVTHLIELPVDSNVPSDWVKVNSTKKTIRYHPPEVLSALDELTLANEELTVVCRATWDGFLRTFGGFYSEFQSTVQALATLDCIYSLAMLSRNKDYVRPVFVSDDEPVQINISRGRHPVMENILQDNFVPNDTNLHADAQYCQIITGPNMGGKSCYIRQVALIALMAQVGCFVPASSAKLHVLDGIYTRMGASDSIQMGKSTFLEELSEASHIIQHCTNRSLVIIDELGRGTSTHDGVSIAYATLHHLLESRKCMVLFVTHYPEIVDIINEFPGSVGPHHVSYLTPQKEKATATDHDDVTYLYKLVPGVSERSFGFKVAQLAQLPSSCIRRAVEMAARLEAEVCKRDKNKVLTNCSMHNSESKDADLEEIEKAYRDLFFHVNLSLNEEEDDARRLDYLKHSKCLAQKLVNR
The following text describes a protein:
Function:
Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. Binds GPI-anchor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGLLTDPSAGQGKLTKALLKYYTKLCVLLYIGGIGWFCSLAYTPMNAGTYFSENALLPGLVKSEFREDAIAKTYHSELLDEMKKYEDSIPYPWLLAKMKQIGLDTYTHNFTLNYPLGKPQKFVGKNVYGILRAARASSTEALVLSVPYRPPLSVHATTAPSIAIMLAFAKFANREKYWAKDIIFLITEHEQLGMQAWLEAYHGVACGNDGTLDHGDIKGRAGAIQAAINLELHETAISQVDIKIEGLNGQLPNLDLFNLAAKMLLKEGVPHTFKNRPNKHLKDPVNDWFYSFQTLLAMISTQATGIPNGNHGLYHRFGIEALTLESTPLKGGNKAGFPIVGRIIEGIFRSLNNLLERFHQSFFFYLLPSSERFISIGLYMPAICLIAGALFIKACANWCQLQENQAETEDEKTKTPETKKQVKSSVKPRDSKNYWKEMETRFQTEIQTHNPPDPDSVNFISILCVFLMSHVLGVLIMNSPQLLTTLGGQYNYSTDASLFYGFIAISVVLLTMPLFIPFKACEKSMSVLNILSLLELGTTLICVSMNNFSLALFCAIIYVPLALIIGITRCRLCSAIKKIVWLLAHPLVVLTATVLVYTFFMFPGEKFEDNFHRGVAATQQAIVFSIVDSMIYGNWLFSVVTSVFISNWLCFWIVAFAKVPQDIPKKKID
The following text describes a protein:
Function:
May play a role in septum formation.
Sequence:
MPAGLPGQASVAVRLSCDVPPDARHHEPRPGMTDHPDTGNGIGLTGRPPRAIPDPAPRSSHGPAKVIAMCNQKGGVGKTTSTINLGAALGEYGRRVLLVDMDPQGALSAGLGVPHYELDKTIHNVLVEPRVSIDDVLIHSRVKNMDLVPSNIDLSAAEIQLVNEVGREQTLARALYPVLDRYDYVLIDCQPSLGLLTVNGLACTDGVIIPTECEFFSLRGLALLTDTVDKVRDRLNPKLDISGILITRYDPRTVNSREVMARVVERFGDLVFDTVITRTVRFPETSVAGEPITTWAPKSAGALAYRALARELIDRFGM
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MATETKPVAAEDPKVDLFEDDDEFEEFEFGEEWDDKEEGKETVQQWEDDWDDDDVNDDFSVQLKKELESSSEKS
The following text describes a protein:
Function:
Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLLSLLNSARLRPELLILVLMVMIISMFVIPLPTYLVDFLIALNIVLAILVFMGSFYIDRILSFSTFPAVLLITTLFRLALSISTSRLILIEADAGEIIATFGQFVIGDSLAVGFVVFSIVTVVQFIVITKGSERVAEVAARFSLDGMPGKQMSIDADLKAGIIDADAARERRSVLERESQLYGSFDGAMKFIKGDAIAGIIIIFVNFIGGISVGMTRHGMDLSSALSTYTMLTIGDGLVAQIPALLIAISAGFIVTRVNGDSDNMGRNIMTQLLNNPFVLVVTAILTISMGTLPGFPLPVFVILSVVLSVLFYFKFREAKRSAAKPKTSKGEQPLSIEEKEGSSLGLIGDLDKVSTETVPLILLVPKSRREDLEKAQLAERLRSQFFIDYGVRLPEVLLRDGEGLDDNSIVLLINEIRVEQFTVYFDLMRVVNYSDEVVSFGINPTIHQQGSSQYFWVTHEEGEKLRELGYVLRNALDELYHCLAVTLARNVNEYFGIQETKHMLDQLEAKFPDLLKEVLRHATVQRISEVLQRLLSERVSVRNMKLIMEALALWAPREKDVINLVEHIRGAMARYICHKFANGGELRAVMVSAEVEDVIRKGIRQTSGSTFLSLDPEASANLMDLITLKLDDLLIAHKDLVLLTSVDVRRFIKKMIEGRFPDLEVLSFGEIADSKSVNVIKTI
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
Subcellular Localization:
Cytoplasm.
Domain:
The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.
Sequence:
MAKKDYYEVLGLQKGASEDEIKRAYKRLASKHHPDKNQGSKEAEEKFKEINEAYEVLGDDQKRAAYDQYGHAAFEQGGGAGGFGGGFGGADFGDMFGDIFGDIFGGGGRGRQRVVRGEDLRYDLEISLEEAVKGTTKDIQINTLAHCDSCGGSGAEKGSKVETCPHCHGSGRIRRQQGFFVSESICPTCHGSGKKIEKPCRNCHGEGRVHKKENLSVKIPAGVDTGNQLRLAGKGAAGENGAPAGDLYVVIHVREHNIFERDGSNLYCEVPISFATAALGGEIEVPTLDGRVKLKIPAETQTGKLFRMRGKGVASTRSGYAGDLICRIVVETPVNLTSEQKELLHKLEESLQGKDLSKHAPKSSGFLDGVKKFFDNLGKSDK
The following text describes a protein:
Function:
Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.
Sequence:
MRRIMMFTGIINHCGEIRSMEALPDHTVLSIDTQFSDLQLGESIAIDGICVTVTQKKLGSFSCDLSPETLACTKARDYKIGSRINLERALRLTDRLGGHFVSGHVDQTAILESQKKHAEFIQMDFKNSSEERWNYLIPKGSVAVNGVSLTVNSVAGDYFSVMLIPHTLEHTNLNDLKEGQIVNIEFDLITKIIVQKTREALSHAKTI
The following text describes a protein:
Function:
Functional small GTPase that acts as a negative factor controlling the light-dependent period shortening of circadian rhythms and light-induced phase resetting during the subjective night. May protect the clock from excessive or mistimed light. Suppresses red and blue light-mediated photomorphogenesis and is required for light-controlled inhibition of endoreplication and tolerance to salt stress. The entrainment of the circadian clock is independent from the other pleiotropic effects. Could be a regulator of seedling establishment.
Miscellaneous:
MISCELLANEOUS: Has a GTPase activity despite the replacement of the highly conserved Glu-94 for His.
Subcellular Localization:
Nucleus. Cytoplasm. Note=The localization is not affected by light, but the nuclear localization is essential for the circadian function.
Sequence:
MKFWRERERENKEQILAPLCGQVRVLVVGDSGVGKTSLVHLINKGSSIVRPPQTIGCTVGVKHITYGSPASSSSSIQGDSERDFFVELWDVSGHERYKDCRSLFYSQINGVIFVHDLSQRRTKTSLQKWASEVAATGTFSAPLPSGGPGGLPVPYIVVGNKADIAAKEGTKGSSGNLVDAARHWVEKQGLLPSSSEDLPLFESFPGNGGLIAAAKETRYDKEALNKFFRMLIRRRYFSDELPAASPWSISPVPTSSSQRLDEITSDDDQFYKRTSFHGDPYKYNNTIPPLPAQRNLTPPPTLYPQQPVSTPDNYTIPRYSLSSVQETTNNGSARSKRMDINV
The following text describes a protein:
Function:
Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.
Subcellular Localization:
Nucleus.
Sequence:
MGKRKKSSRQPQQPKKKEPLPSTFACLFCNHENSIVVKLDKKLGLGHLSCKVCGQRFQTGINYLSAAVDVYSDWVDACDAVAKDTASKYEADEYATRPSPRTYSPEGRGIGVAEPASDLGED
The following text describes a protein:
Function:
Involved in the uptake of ammonia.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTTPTNFTTEIDKLHAEITRLETGFYENVNSFFLCSMALIIFFMQCGFAYLEAGAVRSKNTTNILIKNLLDSCICIIGYWAIGWALAYGDSGEGVNLFVGHSQFFLSGFSDYPRFFFQYVFSATAATIVSGAVAERCEFITYVTYCTVISTFIYPVLTHWGWTENGWMAKGITSGIIDTKYDDFAGSGLVHLCGGSISFLAAWIMGPRIGKFPDDEDDESDEILGHSVPFTALGGFILMFGFLAFNGGSVASISHAGDGHTVALAMINTILSGAFAALIYLGVHYYQHGKWTLLLTINACLSGMVAACAGCNKMEPWACIWVGLGAGLIYLAFSKLMIRLKIDDPLDAFAVHAGGGFWGLMSSSIISHGGVAYALADAVSGAKNSGDHLTQAFAQLGWQMICALAIIAWSLGVMLPIFWILKKTGKLRVSEEVEINGLDVFKHGEMAYPLRAYGHGWHDFERANKIQAFSAKITVGEGKNTRIMKIHPEMSIEQLASVYDRSGNIIPMPKKSRTLFTNSAERKMSQMMYDENKM
The following text describes a protein:
Function:
Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MDMVGKLLQQLLLGVIILAATTASIPNSNCERMCGEVEIPYPFGTSEGCYLDKPFLITCNHTFPPPKPFLDIDLPVVDISVPNGELRVSNPVALLCKRGYSTYKRNIATVDYTRISALLNLSSFRISETRNKITAVGCDVYTYIQGLDHGQKGFTTGCLSLCDQNLSVANGPCSGVGCCQTSIPKGATGYILNVRSLSNDTLPGGKHQCGYGFIIEEQAYKFSSLDFRNLKNRTTVPLVLDWAIGNKTCKDAQKNKTSYACKATQSYCYDSTNGPGYRCICSSGYHGNPYLPDGQDDSCQDIDECKLGHWKLACNATTTCINTDGNYTCTCPKGYEGDGRIDGTDCRPIVGQSNNKIISIALGVSISLLVLLVGTSWVYWGLKKRKLIKLKEKWFQQNGGLMLQQRLQHHTGSMDTTKIYSAEELKKATDNYNKSNILGQGGYGTVYKGVLADNKVVAIKKSKIGDQSQIEQFINEVVVLTQINHRNVVKLLGCCLETEVPLLVYEFITNGTLSDHIHNKSRSSLLSWDKRLKIAKETAGALAYLHCEASMPIIHRDVKTANILLDGNHIAKVSDFGASRLVPLDQTQLTTLVQGTFGYLDPEYFRTSHLTEKSDVYSFGVVLAELLTSEKVISFVRPESERNLATYFVSMVEEDRLLEILDDHIYNGSNAEELKNVANVAKRSLSVKGDDRPTMKEVAVELDGLRNKEKHSRKKS
The following text describes a protein:
Function:
Exhibits ATP hydrolysis without substrate. Phosphorylates D-ribulose.
Sequence:
MVVALGLDFGTSGARAIACDFDSDRSVSVSVTFPKTSQNWPQVWREALWQLLTQIPADWRSRIERIAIDGTSGTVLLCDREGQPQTEPLLYNQACPIDLADLADWVPADHAALSSTSSLAKLWFWQQQFGALPPDWQILAQADWLSLQLHGCSQQSDYHNALKLGYSPDRERFSKNLLDSELGALLPVVHEPGVAIGPILPAIAQEFGLSPDCQICAGTTDSIAAFLASGAHQPGEAVTSLGSTIVLKLLSQVAVSDRLTGVYSHKLGGYWLTGGASNCGGATLRQFFPDTELESLSCQIDPTKKSGLDYYPLPSRGERFPIADPDRLPQLEPRPENPVQFLQGLLEGLTQVETLGYQRLQDLGATPLKRIWTAGGGAKNAVWQQLRQQAIGVPIAIAPNTEAAFGTARLAAFGLAAFHSAGLKRT
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MMEVELVKGEAELERQSSVIESFPRDLLRRLSGNNCFNEQREVPSGESDEVELNLNLGLSLGGCLGVDPRGKKLIRSSSIASFSSLPWEHEFSPGTPTMVRTSSLPTETEEKRRKMKELQGLRRLEAKRKRLEKRKSIKSCNPKSDVGMDGGKSLAQPCTVNGRLSLPIGSQFSGLFSVATPPGLRPWTSGSKITAAQGSELENQTPARGLFNLPAFSSNADFNDTATVQSVSAHKTAIAPLVSGARITITPIGGEEDPLEKKKKKVRVTRDASLGRNMIGEMPCVSTRGDGPNGRRIEGFLYKYKKGEEVRIVCVCHGSFLTPAEFVKHAGGGDVTHPLRHIVVNPMPSALMSLR
The following text describes a protein:
Function:
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
Subcellular Localization:
Cytoplasm. Nucleus. Secreted.
Sequence:
MLSFERPPPLAAMHAGREPPSVAIQPLRNTHPQRRRTKRMERGKAGLSSKKLAVLSRSLLICSSSAHEDASSPEEKYREPWDVPLEDRRPDGTLMSRSVSVQTSYRGHEGPKRAMRRSFSIKETSFWRMCVATRDDALHTADRKLQNCDNEASVAQDLHRETYIYFGERLAPFNGQVINEQPNPEPDLHKHKTTESRNTSSKAFTENRALFTNTTESQQLGYGYGEKEPMGNNNNLQMPIIKVSDDDVKDIDNEDQGCQEMSCKRSRSNSTSVHPYWIGDLETIIMKTPELFPCSAHNTAAFYGNRKSLSQQLEFPHSVPQAVVRPSRSLSSAHLVPSCSSVQAFIISNIVLMKGHGKGLGFSIVGGRDSMYGPMGIYVKTIFPGGAAAADGRLQEGDEILELNGESLHGLTHEDALHKFKQVKKGLLTLVVRTSLRVGAVMGSHGQASQLCRSRSLSSSTAISRVSADLGEYNCLINPAKAQDRIMMEITLHKEFGVGLGIGLCCVPSSGGCPGIYIHTLSPGSVVHMDGRLRCGDEIMEINETVVCNMTLNDVYTVLSQCSPGPVHIIISRHPDPKVSEQQLNEAISQAVENSRLRKDRSQWSMDGCNSSLRRPESCCHSRQKCMRCVDRSTSQLTCRRTQKPMIRSCSEGAYSQRCCIPNSTTAQSFLHTDHVSLTTNSETSLNNTLSQSSFTDDDYNIPYKCPVNFNGKQTFDVNASSGLVNQPRKYCRQQQEVSSQEALNVSSGSSRDSPVKEEDLMLSQSNCQFFCSLYRALRKISRLLFKNEVVEHAELGTKASACISEPKSDSTHRGDRLHKDPECSSQVCGSSKRVGLRRQAHLEVSTDQPLDPWVKLTDSPENQSYCSKTMSDHNGDSEVNGTASETTESKSEQATSVKKGPPVAPKSARARQSMKSIKSGKPITEAFRNQQDNRSHETGRTFGISSRAASSGGNLSIRQKISSFETFSSPDGSERPSWRMAPTASVPPTEKTTKTSSADYSNADRTRVNTSNLRNNDYCQSTPPISATTLLSEEHSTSLILESHPGVEKQSTSHDSETCKSIPVEEPTVDPTEEITTAVETEQELVSSAKSSVDTEHKPVSSSETEQEPVSSTKSSVETEPVTSAETKQEPVSSEKDLPSVTHVPRRSSSSKEAPGEKAEDAGTHAVSLRTRSLPLSPSSDGPISSGLEGESLGIILSFSNQVSSALMRSMQSLPQSPCIRLGNPWSAPPGSPLHNPIEEDSAAENPHASTALENNEKGFSVSLAELRERTIERGEECKTDDWKPEQALTSASAACAQSMLSVLPQPEIQRMIQEVKDLDEDTLRQLEDIHVVILHKEEGAGLGFSIAGGIDLENKATTVHRVFPSGLAAQEGTIEKGDEVLSINGQTLKNVTHSDATAILRQSRTLKQAVVVVSKNKDAEGKSANANESSCSGGAESSIAGDDGGEVVTFELEKNAGGVGFSLEGGKGSISGDRPLAVNRIFTGSDAEQKGLKSGDEVLQIQDSSLQGLTRFEAWTLIKNLNDGRFTLIVKRRRCEQS
The following text describes a protein:
Function:
Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.
Subcellular Localization:
Cell projection, filopodium tip. Cell projection, stereocilium.
Sequence:
MTLTRGSFTYASGEEYHGEWKEGRRHGLGQLKFQDGTCYSGQFENGLFHGSGVLLFTDGSRYEGEFLNGQFQGTGVFSRYDGMKFEGEFKDGRVEGYGLLTFPDGSHGVPRNEGLFQNHKLQKREKCPGVVQRAQASASTAHSLAF
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MALYGNQGPSSSQYYNPSQPTCHNTLYNCSQPCVEGFSYCLDHISEDRNAPYRSCTFVFSNGKRCATNVLKGERRDGLCQDHAKRSALCKMKTLRKRQPPESLETLIDDLQHYSEAGNEEKATGTLSLIEKLSLNASTQKLQDYASESDSEDELPTAEQTIRQEDDSDAESIDSDQDDPLRHAGVFTPEEVVLLTRDKLIKLQALYLDQFKRLHHQLKCARRRYLNGVKREKENGVASAPYPDTPSERRAVAKLRSLRRFQRHRGCEALLHHQLQEKRLQVTQGVNYKAPPTPKCSFVDCGIKCTNPAVPLTKHCTKHVLNDSSQMLFRPCGAIFHDNECKEPVINFSENTRCVYHTMMPPMMLVEQDICVASPLISVDDEIEKVEVKIEVDDAGQTCG
The following text describes a protein:
Function:
May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.
Sequence:
MITKNIDENLISVIPEDSDDLLNLRRIIKENDKIIGDTTRVLKQDKDYSRPDKGERIKVRIALTVEKISLDDVLDRLRIRGTISESSNESVPHGTHHSFILKINDGITISKKKWLPFEKNLLESSNNQVGFVLVAIDTGDSGIARLRGTHLEFMPNIYSGSGGKRYKTNFNIEKFFEQVQQAISTILKEGDSIVIFGPGETKKRFANFIQKSQNLQKFKVQVVEGIDSGGEDGIYTFTKSNTMKEIMSDSKLAKVSSIIDEVMLLANKKSTKFTMGFDETFNANQMGAVESMVFSDKAIQDDEQKMIDFLNDMENKGVKMYSVDSSTDIGLRVTGLGGIVSLLRYSIES
The following text describes a protein:
Function:
Involved in mitochondrial genome encoded proteins translation; Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MAKASKGKHQSGPSNHSESIDLVRKALYGNKKVRSLKMNPDMWEKHEVINRAWRIHEYRQEKQRENLLKNQFSAMKIACEELKHTSETLYKAAMSDSINRRFPVETRTPTDTPPRLSK
The following text describes a protein:
Function:
Metalloprotease. Was previously shown to degrade COMP. However, a later study found no activity against COMP.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MLGGPSPRSPTPLLRPLLLLLSALAPGAHGSAPGHAAQGRAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSARPTAPAFYELQYRGRELRFNLTANPHLLAPGFVSETRRHGGLGRAHIRASAPACHLLGEVQDPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDGVPARTGRPQPHVVYKRQAPEKRAEQDDSRAPGTCGVEGSPELEFRRERWEQRQQCQRPRRLQQRSVSREKWVETLVVADPKMVEYHGQPNVENYVLTIMNMVAGLFHDPSIGNPIHITIVRLILLEDEEEDLKITHHADNTLRSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCNINEDTGLPLAFTVAHELGHSSCTTLRLSPGPAAAASTSPGSSTVGGASAWTTLPPRMSSTSPQCRLASCTMWATSVASSTGPTLPSAMTWIMSATHSGALWGPPVTPSWMQLWMVPGVGRARPKYKGKYCVGERKRFRLCNLQACPAGRPSFRQVQCSHFDAMLYKGQLHTWVPVVNDVNPCELHCRPSNEYFAEKLRDAVIDGTPCYQGQASRDLCINGICKNVGCDFEIDSGAVEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRIEEVAEAANFLALRGEDPDKYFLNGGWTIQWNGDYQVAGTTFTYARTGNWENLTSPGPTDEPVWIQLLFQESNPGVRYEYTIHREADGHGHIQPPEFSWHYGPWTKCTVTCGTGMQRQSVHCTERQAGPVDERHCDPLDRPDDRQRKCSEEPCPARWWAGEWQLCSRSCGPGGFSRRAVLCIRSVGLDEQSALEPPACEHLPRPPAETPCNRDVPCPATWAVGNWSQCSVTCGPGTQHRSILCTNDTGVPCDEAQRPASEAACLLPPCLQAVDTPGPEGSGSGSSSHELFNEVDFIPRRPAPRPLPPSPPEPAGMGNAIGEEDPKMGLPGPVFVDDFYYDYNFINFHEDLSYGIFEEPDTDLTGDWMPPPLSSPPEPPTGTPVPATEPPGAEKEGAVPGPRWAGHSPPPPSEQTPGNPQLNFLSEEDAPIGAPDPGLPSLLWPPTPVSLETPMPPGNQTSFPGGEHSQGQPPLPPPQGERTNEVSEDNDEATGHKAPYLPQKPSPTSPSLPSISTTHSSGPNMVELWTGKVVAWDPALDSGLGPQPPPTAALPDTWGTDSPLEPGSPTLSTPRMALQDLQTGAVPGTFLRTAPTGLGNTPWVTALSPGPLGQPESPNSDESPGPVLLSIPAQDSLANSSRAPAPLVPSPTEAEAPVYLPAARNASWEVGNWSECSTTCGLGAVWRPVRCSSGREEDCIPAGRPQPARRCHLRPCAAWHTGNWSKCSRSCGGGSSTRDVQCVDTRDFRPLRPFHCQPGPAKPPARRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCPEPGLCEEALRPNSTRPCNTHPCTQWVVGPWGQCSAPCGGGVQRRLVKCVNTQSGLPEEDSDQCGHEAWPESSRPCGIQDCELTELPRCERDRLSFGFCETLRLLGRCQLPTVRSQCCRSCPLPGHGAPSRGHQRVARR
The following text describes a protein:
Function:
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVKIVSKPTSQLNYTVEKIKNISNKLGFEVVDIDFDYVIAVGGDGTLLRAVKLGKPVIAIKAGRRGLLMDVPVDKIEDALLRLKKGDYNEEEYMLLEMVHNDKVELGFNEIGILYDRPEAIKVGISFDTERVSVEGDGVLVSTPQGSSGWGMSATNSLLYKDLNAIEIIFVNPIFYYLRSVVIPPKSLILRLEDKGYPQTARVVVDGEVVTLIKTNQEITVRVSQHKAKILRFFKLDLIGEVLHAYHI
The following text describes a protein:
Function:
Probable constituent of the synaptonemal complex during meiosis. May interact with RED1.
Subcellular Localization:
Nucleus. Chromosome. Note=Synapsis of meiotic chromosomes.
Sequence:
MSNKQLVKPKTETKTEITTEQSQKLLQTMLTMSFGCLAFLRGLFPDDIFVDQRFVPEKVEKNYNKQNTSQNNSIKIKTLIRGKSAQADLLLDWLEKGVFKSIRLKCLKALSLGIFLEDPTDLLENYIFSFDYDEENNVNINVNLSGNKKGSKNADPENETISLLDSRRMVQQLMRRFIIITQSLEPLPQKKFLTMRLMFNDNVDEDYQPELFKDATFDKRATLKVPTNLDNDAIDVGTLNTKHHKVALSVLSAATSSMEKAGNTNFIRVDPFDLILQQQEENKLEESVPTKPQNFVTSQTTNVLGNLLNSSQASIQPTQFVSNNPVTGICSCECGLEVPKAATVLKTCKSCRKTLHGICYGNFLHSSIEKCFTCIFGPSLDTKWSKFQDLMMIRKVFRFLVRKKKGFPASITELIDSFINVEDQNNEVKERVAFALFVFFLDETLCLDNGGKPSQTIRYVTSSVLVDVKGIVIPNTRKQLNVNHEYKWHFTTSSPKAESFYQEVLPNSRKQVESWLQDITNLRKVYSEALSPSSTLQELDLNSSLPTQDPIISGQKRRRYDLDEYLEEDKSSVVNDTIKAKDFDESVPAKIRKISVSKKTLKSNW
The following text describes a protein:
Function:
Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR). Required for the transport of CALCRL to the plasma membrane. Together with CALCRL, form a receptor complex for adrenomedullin/ADM. Together with CALCR, act as a receptor complex for calcitonin/CT/CALC. Together with CALCR, also act as a receptor complex for amylin/IAPP.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MEGQCLPLQLLLLVFTVTIGLDAYSGTVAPPSNASLSLEGGPNVTAPNYHRNLEGNSTIDVDIYYYLAEDCWLKFYLQMTNVSKEHLCEWRAIGRPYSILRKCLEDYADKWNYGFPNALAEYYIVLSHHLYFRNCTSELHPPFLDPPENILLPLIITPICLIPFLITLVVLKSKDGETQA
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MVNPRCYLDISIDGEMEGRIVVELYSDVVPRTAENFRALCTGEKGISPRSGVPLHYKGSHFNSIIRGLMVQGGDISAEEGVPGESIYGEKFEDENFELKHSRKGMLSMANSGPNSNGSKFAILTNQATHLDGKHVVFGKVIKGLGVVRSIEYVATVGEYYPTVDVVIADCGEIPEGADDGTINFYGDGDVYPDWPVDFDAKVDDVSLIINAVDFIKLLGNEWFKKHDYKMAIRKYRKALKYLDLCWEMEGIDSASLMKTKSQILTNSS