lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto replicating DNA. It performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer (By similarity). Plays a role in the maintenance of heterochromatin (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 2130 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MEASHLQIYWHDSQPVYSLTFQKNSANDKLFTAGGDNKVRIWKLNRDENGQNGGVRKIESLDFLGSLTHHEQAINVIRFNSKGDVLASAGDDGQVLLWKQEDPNTQQESVVRPFGMDAETSEADENKEKWVVWKRLRGGSGATAAAEIYDLAWSPDNRNIVVACMDNSIRLFDVGAGMLVCGQSDHGHYVQGVAWDPLNQFILSQSADRSLHVYGVILSSAGVVTGLKLRSKIAKAELPCPGDVLRTNYLFHNETLPSFFRRCSISPCGGLVVIPSGVYKVAGDEVANCVYVYTRSGILNSAGGVKNRPAIRIPSLKKPALMAAFSPVFYETCQKSVLKLPYKLVFAIATTNEVLVYDTDVLEPLCVVGNIHYSPITDLAWSEDGSTLLISSTDGFCSYVSIDTETQFGSRIEPPAMHAEPLDTDESAVAAKNQREAGGIVNMLPVKKIPCNSSDSKKRRIHPTPVDL
The following text describes a protein:
Function:
Effector protein that participates in the suppression of macrophage apoptosis by blocking the extrinsic pathway. Interferes with caspase-8 activation and binds to the host E3 ubiquitin-protein ligase RNF213, whose fusion partners have anti-apoptotic function.
Subcellular Localization:
Secreted. Host cytoplasm. Note=Is secreted into the macrophage cytoplasm. Might be secreted via a type IV pili apparatus that seems to be encoded in the same operon.
Sequence:
MEAALAIATLVLVLVLCLAGVTAVSMQVRCIDAAREAARLAARGDVRSATDVARSIAPRAALVQVHRDGEFVVATVTAHSNLLPTLDIAARAISVAEPGSTAARPPCLPSRWSRCCCASPVRVHI
The following text describes a protein:
Function:
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
Miscellaneous:
MISCELLANEOUS: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.
Subcellular Localization:
Cytoplasm.
Sequence:
MKTSLISGERFYSLEESNLVKEIFKKAVKIFEAFGYDYINLSHFEPYEFQELTFGEGSKEAITFKDSYTKESFGLRLDFTTQVVRTISHLRNVKLPERVYYFGKVFSLDRRGFEKLQTGVELIGEKSILADFEVIQVLTEFLKSLGLKDLKVILSHAGIVRKVADEREELLRAFSERNLEALKEVLGNDIKFFVEVSKNPEVLNFLEKYDLEKEKEELLELGKLLEEFGIDYAYDLGEVRNFPYYTGVIFEIYELKSGKALAGGGRYDNLSKIYGKEYPATGGAVYLERLLDILPKNVEKKDYFVIDKTKKRLGLKLADVLREKGKKVGMEIVKERGLEHSLIYAFDKGFKEVLLVEDEIVKVYTTPKDYVVMKIREFLDLIE
The following text describes a protein:
Function:
Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.
Sequence:
MSTTTTRNVHQIFLAVHRGWIDHLRRVLEKDGRTMKNLCECNEHKETPLQVAIRERQFKVIEFLVQSVKDHIQIHCHPHSRWVRRMSSFSWDKINVELFAIGPAEFGREFTQIFVLPSADVAILRDMASSNRIGIFKLIEYLIDVVNDDTSWFEFFLNSMVASSMDRADKIIALELMGSAFILKIRLADEQFEPDEIAGGLRGLQCWKKALELRNSTANGRRPMPKIPHVLSSAARNALGDSPEVTTLEQLQELENQLRRHDRRSLITDQAFLVIQRTFAQRQLGAEPNLFHLKTLLDYGKQFKTTGDHFANTEIHYGRAINISLMIMQQFNRADSPKCFQVFVEAFLLFANVLNGLGRKTANNAERIKELTFAHVLEAIKFGFTIATNLILLPPICDQHSMWQSLVMRKIYFLMVTLFKMLPKFDPPEGERLCRVLANFFRVEQLRNGFASMLHLAVEGFVSARIDVTVRAEIVTFFLDNGADPKSLDRNGQSPLHILAGKCQPNSNELFFEVFQAVLEAGGHLDQVTPDGKTVIDVLQDKKKQFQESLDPRVDHWINTVMSLECYCAQKIRQESIPFEEDEQQLPLCLQQFIEQHSPLKSQLQGDNWIII
The following text describes a protein:
Function:
May act as a GTPase-activating protein for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (By similarity).
Subcellular Localization:
Endosome membrane. Cytoplasmic vesicle, autophagosome. Note=During starvation induced autophagy is relocalized from endosomal localization to LC3-positive autophagosomes (By similarity).
Domain:
The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site; The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins. LIR 1 is also implicated in interaction with retromer; LIR 2 is only implicated in interaction with ATG8 family proteins.
Sequence:
MYKSVSETRHPLQSEEQEVGIDPLFSYSNKTRGDLSQNGRGSNSTLDTEGTFNSYMKEWEELFVNNNYLATVRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISKIKELRAWYSSIKEIHITNPRKAAGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIIFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLMAPIPFARPQDLGPTVAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADSLNLSLVDYVFTAMLLYIRDALISSNYQTCLGLLMHYPIIGDIHSLILKALFLRDPKRNPRPATYQFHPNLDYYKARGADLMNKSRTNARGAPLNIHKVSNSLINFGRKLISPASAPGSMGGPVPGNNSSSSFSAAIPTRTSTEAPRHHLLQQQQQQQHQQQQQQQPQQQQQQHQQQQQQQRLMKSESMPVQLNKGQSSKTISSSPSIESLPGGREFTGSPPPSATKKDSFFSNIARSRSHSKTMGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDMHLVNIQDVVLQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAGENEQITIADDHYCSSGQDQGSQVPRAAKQASSEMPGCTGGTTPDDFILVSKEDEGHRARGAFSGQAQPLLTLRSTSGKSRAPACSPLLFSDPLMGPASASASSSNPSSSPDDDSSKESGFTIVSPLDI
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
Sequence:
MNRFFNRELSWLAFNTRVLNEAKDESLPLLERLKFLAIYDTNLDEFYMIRVAGLKQLYEHKIASKGIDGASPEEQLEKIKHYLAHEIEERELEFQKIQALLFKKGLCITPYNELNLEQKAKAKTYFKEQLYALVLPFKLDSSHTFPPLANLTFALFARIKDKETQIISYALIKLPSFIFRFVELEKGLFVLAEEIVEAHLEELFLEHEILDCMAFRVTCDADIAITEDEAHDYADLMSKSLRKRNQGEIVRLQTQKGSQELLKTLLASLRSFQTHSYKKHKLTGMHIYKSAIMLNLGDLWELVNHSDFKALKSPNFTPKIHPHFNENDLFKSIEKQDLLLFHPYESFEPVIDLIEQAASDPATLSIKMTLYRVGKHSPIVKALIEAASKIQVSVLVELKARFDEESNLHWAKALERAGALVVYGVFKLKVHAKMLLITKKTDNQLRHFTHLSTGNYNPLSAKVYTDVSFFSAKNEIANDIIKLFHSLLTSSATNSALETLFMAPKQIKPKIIELIQNEMNHQQEGYIILKANALVDSEIIEWLYQASQKGVKIDLIIRGICCLKPQVKGLSENIRVYSIVGKYLEHARIYYFKHENIYFSSADLMPRNLERRVELLIPATNPKIAHKLLHILEIQLKDTLKRYELNSKGRYIKVSNPNDPLNSQDYFEKQALKTF
The following text describes a protein:
Function:
Single-stranded DNA (ssDNA)-binding protein that mediates the recruitment of telomerase to telomeric DNA. Telomerase is an essential ribonucleoprotein (RNP) enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER. Acts as a part of a replication protein A (RPA)-related subcomplex of the holoenzyme telomerase ribonucleoprotein complex: TEB1 specifically recognizes and binds telomeric ssDNA, thereby mediating the recruitment of the holoenzyme telomerase RNP complex to telomeres. TEB1 is related to RPA1 subunit of the RPA complex but is specific to telomeric DNA, which is not the case of RPA1.
Subcellular Localization:
Chromosome, telomere.
Sequence:
MKLTKGGSYILKKVDRKQFYQDEEIVMQIKKILGQKTTDCKQYIKCECIDGLGDEALIYFEMLANQNQHLQKNDVIMIQDYLNDKTQNDKIVVLVTRFQFCKASHVQPKTAQKESIQLLNTEKTIIQKSKITKNPAEEVLKFIEVNEKDNSSNSEDMIIEQQKQEIKNNQKEKQSINGFNLEDSYSNISDITNFGGKSNFNIGSLSDQLSKQTLLISQLQVGKNRFSFKFEGRVVYKSSTFQNQQDSKYFFITAQDANNQEINLSFWQKVDQSYQTLKVGQYYYFIGGEVKQFKNNLELKFKFGDYQIIPKETLSANYVQPLALQPSKQFGNDSIGDSDYSIHNLIEKEESIAQKGYNGQKNNKYRQNNNNSKHTLLISEVLKTSKQYLSVLAQVVDIQSSDKNIRLKICDNSCNQELKVVIFPDLCYEWRDKFSINKWYYFNEFVRQIYNDEVQLKNNIHSSIKESDDQRKVITYNQEQGVFKKSISINSNDSFEIKPKISYKNNSNQEQRIYSSIEEIIQQAQASEIGQKKEFYVYGNLVSIQMKNKLYYYRCTCQGKSVLKYHGDSFFCESCQQFINPQVHLMLRAFVQDSTGTIPVMIFDQQSSQLINQIDPSIHVQEAGQYVKNCIENGQEEIIRQLFSKLDFARFIFEIQFENKEFNNEQEIAYKVLKIEKENIKEESKYLLKKLEHLINNNQNN
The following text describes a protein:
Function:
Ligand-activated transcription factor (By similarity). Positively modulates expression of homeobox protein lin-39, perhaps by binding to the sequence motif 5'-TGAC-3' in regulatory regions of the lin-39 gene, acting in the embryo, and also in the vulval lineage.
Subcellular Localization:
Nucleus.
Sequence:
MISGPFLHFDPTVPLQTVMIGHPATSPLSLPSSSSSPTVADPSNIHCRVCERRYDGSQHFGIDICRACAAFFRRSVAVKKTFVCRRGTNKCELNTVSRKTTCQKCRWMRCLLVGLNVDAVVGRRSPDHVKTTSRDESVKKEDEESDTGSEGKSCEDMDVSHPIEQFQQQISFSVHRPIPTIGNPNIYTTRASLINKVLINYNEFTKSRLDVELSLKHMQQDSKVFGSTGIPIVPATREIISEIYQKQFGLLHIFLKNTFDEYAECDVQEQKRICAMFYPVLWEIESCYWTYRNMPVQPEYETLMMCTQTTYIDSKNVRYWLGNTTGLNESDIQAVEARLENLLTKARNLVLEPMHKLIIKEFEFITLLALNIWAPRNHRGCVSEDRAEQVRDALFDDLHYLYCDGLKIDKYSSRMGEMMCLHTEVQNADMSSTIKNILFSDLNAYLYSI
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Sequence:
MICEVCGENQAKYKCPACGCQTCCLACVKKHKIDRNCSGQKPKSEFIPVKDMNEHTLYKDIQLLDQASIAKLNAADKLEKSNKPPRYLQKIKKECSQRGIDIKFMPNQATRRQENKTYLTQDGKNLMWTTKWRFFNDRQEKKFEMILPPIQDDTNLASALKAIIDASQDDFVAHLNLKDLAVLMVAEGLENGQFFDLSLDFDLNTNLTAKTIIEYPIFHVLPKDHLSDYKLADPFALCQFKEEKVEEVKENVEEEVLPDYEKIKSALKLDLIKNVMKQVDEGN
The following text describes a protein:
Function:
Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation. Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell. Within the RQC complex, mtr1/rqc2 specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and promotes the recruitment of rkr1/ltn1 to stalled 60S subunits. Following binding to stalled 60S ribosomal subunits, mtr1/rqc2 mediates CAT tailing by recruiting alanine- and threonine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal Ala and Thr extensions (CAT tails). CAT tails promote the rkr1/ltn1-mediated ubiquitination of incompletely synthesized nascent polypeptides: CAT tailing facilitates rkr1/ltn1-dependent ubiquitination by exposing lysine residues that would otherwise remain buried in the ribosomal exit tunnel. Following ubiquitination, incompletely synthesized nascent polypeptides are recognized by CDC48 and degraded by the proteasome. CAT-tailed proteins tend to aggregate and sequester chaperones and can induce proteotoxic stress; their rkr1/ltn1-dependent ubiquitination and degradation is required to prevent proteotoxic stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MKQRFSALDIAAIAAELREQVVGCRLNNFYDLNARTFLLKFGKQDAKYSIVIESGFRAHLTKFDRENAPLSGFVTKLRKHIKSRRLTGVSQLGTDRVLVFTFGGGANDQDPDWTYYLVCEFFAAGNVLLLDGHYKILSLLRVVTFDKDQVYAVGQKYNLDKNNLVNDNKSQSTIPHMTAERLNILLDEISTAYASPTSINEPLPDQQLSSSTKPIKVPKPVSLRKALTIRLGEYGNALIEHCLRRSKLDPLFPACQLCADETKKNDLLAAFQEADSILAAVNKPPVKGYIFSLEQALTNAADPQHPEECTTLYEDFHPFQPLQLVQANRKCMEFPTYNECVDEFFSSIEAQKLKKRAHDRLATAERRLESAKEDQARKLQSLQDAQATCALRAQAIEMNPELVEAIISYINSLLNQGMDWLDIEKLIQSQKRRSPVAAAIQIPLKLIKNAVTVFLPNPESVDNSDESSETSDDDLDDSDDDNKVKEGKVSSKFIAVELDLSLGAFANARKQYELRREALIKETKTAEAASKALKSTQRKIEQDLKRSTTADTQRILLGRKTFFFEKFHWFISSEGYLVLGGRDAQQNELLFQKYCNTGDIFVCADLPKSSIIIVKNKNPHDPIPPNTLQQAGSLALASSKAWDSKTVISAWWVRIDEVSKLAPTGEILPTGSFAIRAKKNYLPPTVLIMGYGILWQLDEKSSERRKARRLEMEVVETQGKVSELKMEGTSVTSEDNIQDVVSEVSYNEDTNNQSTPDTTGSDIHIVSEKRGKKGSKVITAKKVSAKERREARRARRQTALEESLKAPISIEDATDPQTILAILKQKKAKKKHAAREMEISSQIPSNDSSNVQTPTAESEIEEDGVSEPISAEVIEDQSRNSEAENEKGLSTEQRDEKKHAKVESFQRQEMPRSLFEEIFFAIDSLTPNPQQQDTVINAVPTFAPYNAMTKFNQKVKVMPGTGKVGKAARESIAYFMKKLPKSSKEAAYLENLKDGEIVAPISVSRLKMVFGSSGNTKKSKK
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
Sequence:
MSEGYTPLVIDSTFLFDSKKIIKERIIPWEGLARSGVVSEDDANHIKLLEKQSIENRNNTVKAQLDLYSKCLLNVLNRVDSKDDVLKNILALINDLLLDVPEFLDAVLKLSEVDKSLPYIPFINHLDNKDNLIKSLSLYNLEILLGKVKTINDDEILIKIFSVLSYLIGESADSNYQFIGVQLLQDLLIVKPFKLVYQNNNLLTNFKPINNLIEKSAKNPNSIGLQLSYNVLLVVWVLSYTAPINRSLIHNFPQLVGNLLSIAKDSIKLKIVRVAVAILKNFVDITISSQEQFKVIKVLLFSDALNTVNTLKERKFASNGSDEELSNDLNYLYDNLQEIVTQKLTSFDEYLTELENPKLISWASPTHKSTEFWLENSGKFKDSNYKLVKRIFEILISNTNDSTTINVILLNDLQFLIKNLGKDLITFINTEKGGQYKLLIMTFLDNSQGDNELKYQALKTIQLLVGHNF
The following text describes a protein:
Function:
Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair. Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA). Possesses both DNA unwinding and annealing activities. Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA. Efficiently unwinds substrates containing 3' overhangs or a D-loop. In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing. Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to sites of DNA damage; localizes to damaged replication forks.
Sequence:
MDECGSRIRRRVSLPKRNRPSLGCIFGAPTAAELVPGDEGKEEEEMVAENRRRKTAGVLPVEVQPLLLSDSPECLVLGGGDTNPDLLRHMPTDRGVGDQPNDSEVDMFGDYDSFTENSFIAQVDDLEQKYMQLPEHKKHATDFATENLCSESIKNKLSITTIGNLTELQTDKHTENQSGYEGVTIEPGADLLYDVPSSQAIYFENLQNSSNDLGDHSMKERDWKSSSHNTVNEELPHNCIEQPQQNDESSSKVRTSSDMNRRKSIKDHLKNAMTGNAKAQTPIFSRSKQLKDTLLSEEINVAKKTVESSSNDLGPFYSLPSKVRDLYAQFKGIEKLYEWQHTCLTLNSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKDVLMILPYVAIVQEKISGLSSFGIELGFFVEEYAGSKGRFPPTKRREKKSLYIATIEKGHSLVNSLIETGRIDSLGLVVVDELHMIGEGSRGATLEMTLAKILYTSKTTQIIGMSATLNNVEDLQKFLQAEYYTSQFRPVELKEYLKINDTIYEVDSKAENGMTFSRLLNYKYSDTLKKMDPDHLVALVTEVIPNYSCLVFCPSKKNCENVAEMICKFLSKEYLKHKEKEKCEVIKNLKNIGNGNLCPVLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPYVAKEFLKRNQYKQMIGRAGRAGIDTIGESILILQEKDKQQVLELITKPLENCYSHLVQEFTKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQQKVLLKEKSLWEITVESLRYLTEKGLLQKDTIYKSEEEVQYNFHITKLGRASFKGTIDLAYCDILYRDLKKGLEGLVLESLLHLIYLTTPYDLVSQCNPDWMIYFRQFSQLSPAEQNVAAILGVSESFIGKKASGQAIGKKVDKNVVNRLYLSFVLYTLLKETNIWTVSEKFNMPRGYIQNLLTGTASFSSCVLHFCEELEEFWVYRALLVELTKKLTYCVKAELIPLMEVTGVLEGRAKQLYSAGYKSLMHLANANPEVLVRTIDHLSRRQAKQIVSSAKMLLHEKAEALQEEVEELLRLPSDFPGAVASSTDKA
The following text describes a protein:
Function:
May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB. Essential for ESX-1 function, required for early replication in macrophages and full virulence in mice.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Note=Cell wall-associated.
Sequence:
MHRIFLITVALALLTASPASAITPPPIDPGALPPDVTGPDQPTEQRVLCASPTTLPGSGFHDPPWSNTYLGVADAHKFATGAGVTVAVIDTGVDASPRVPAEPGGDFVDQAGNGLSDCDAHGTLTASIIAGRPAPTDGFVGVAPDARLLSLRQTSEAFEPVGSQANPNDPNATPAAGSIRSLARAVVHAANLGVGVINISEAACYKVSRPIDETSLGASIDYAVNVKGVVVVVAAGNTGGDCVQNPAPDPSTPGDPRGWNNVQTVVTPAWYAPLVLSVGGIGQTGMPSSFSMHGPWVDVAAPAENIVALGDTGEPVNALQGREGPVPIAGTSFAAAYVSGLAALLRQRFPDLTPAQIIHRITATARHPGGGVDDLVGAGVIDAVAALTWDIPPGPASAPYNVRRLPPPVVEPGPDRRPITAVALVAVGLTLALGLGALARRALSRR
The following text describes a protein:
Function:
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation (By similarity).
Subcellular Localization:
Nucleus. Note=Associates with chromatin.
Sequence:
MACCHKVMLLVDTAGVSAPHSPARRAALRLLTYLSCRFGLARVHWTFKFFDSQGARSRPSRVSDFRELGSRSWEDFEEELEARLGDRPPGAHLPGPTPRATHTHGALMETLLDYQWDRPEITSPTKPILRSSGRRLLDADGEAREAQAALGGFGNAVFLLAPCPHSQRELLQFVSGCEAQAQRVPLTPKQVMEKVLPKRVQEVMIARNITLYWVDTTERSKLWASPDHVGYWTVCELLHHGGGTILPAETWSLGFTKARETVLPCGGELSHKPHPSPWISALPIDATVNCLLYNSEYEASFPRIEGTLFLPVQGKEIEETWAISLEPLAMHQRHFQKPVRIVLRGSVAQWSLPVSSALGTDSWMLQSPEEHRSTQRLLFQELVSRLTAEEFHLVASVDPGEGWPPITGIISPFSANAMILTVFRAKEAEFQSHFLQTAATEGSQDTASLFSDVVDSVLNQSHNLFEDPASSAPCVPEWVQQELSHTSSWSPALVEKWFPFSNASGATSDLMESFWLLHAASPDNDESSKTESELTRCLSELYQRSHEESTVVNQERSRKKRGIPRTPVRQKMNTMSRSLKMLNVARLNVKAQKLHPDGSPDTAVEKGLQKAVIGRTADKLEDRGRILRSSKLKEFKTEEELLAYIHDNYQKAVATEEITLYSCAQNMVSTIKMFLKSKDIKELEVACLSHVNSNLLKTSKTLRQNLAGKMDTEDKVGECQLQVFLRLEMCEQCPSVLDRPDEVERIVEEVTDLLRLVCLTKDSAYLSEFLEEILRLYIGSIPGTIGQLYHSLGLKIPQKLAGVLPTGFFSDDSMSQESMSPPPSSSTHRSVSAITESEQLEELRTRSAKKRRKNALIRHKSIAEISQTLRQIEVPKVSKRATRNENSHSASIQLPVPRKDTIQEVTKVRRNLFNQEMLSPSKRGLKKGLPRSHSVSALECLHHKQDKFKKTKSSTFQGYCKLLTKSVAETPVHKQISRRLLHRQIKGRSSDPGPDIHVVEESPEKEDEMTLRRSPRIKQLSFSRTNSGSFYSVSQPKSRSVQRIHSSQQESEQRENFPVQSIQSPKTLLFGALSEIPSSSKKGSAQIKRSLRSMLDSEISTSYETPKKSNQKSPSFSKTTPRRFPRTAQTLLYTPERLQNSPTEMTSAEGTISEATIKTPSSHGYNSPFASKVTSQKTVSPAKEETSPPLTKLPSTPRESDVQPPQCSSDCTWPHSVNSSPEGPYYPASPPPMAGQARSQCLTPIRYSFRTPPRTALAGTSKQQEHQELPLPRASQTQEPPQGLEKKALKIPKKPAHTSTSPLSPEEHYSGCDVSPHQPRNSLSASPPPGELNWKEHQTSPSVTSSVSCPVPSTPPRTPQRMTCPIPPSPPSKLRRSCRKKSCPPQDFPECHPGPSAAPVLSSATSPGAVTGSREEQSQFSEGQSYLGTGFRSDCHVSSPVLTASDTKCLPLIDEAQLHGLKNQEVKSGILPGEEGEEPESTIADELPSVSDPGILVPAPSSVSSSSELLPYPLCCTADGKQRQDAAQQGSPRASEATSSPQTYEVELEMQASGLPKLRIKKIDPGVLLEAEALGKEAPLGEEGALPALCMPKASKSSGRTEHPYLSPPCLRPSHSTPGKNGGQTFICQSCTPSRCPPSTPSPFQADAGVSWTPSPKQSGKTTPEIIKDWPRRKRAVDCSAGPSAGRGEASMDLPGSLSLLEPEPEGKERSLEQDLSKVLISEEFELEGVCQLPDQSPPKDSASVTEETSWGQFGLGRKRFLSAKEESEYKVKRVCDSLSEDPQASKQKECSPRWSALPLHSVGDDEVFVSGSTPPSGCMVRSCLSASGLQALTQSPLLFQGRTPSSHSTDTRDEEVDVFPSTAEESPFSHTLSRKRPFRTYTRKKLIS
The following text describes a protein:
Function:
Transcription factor which modulates genes involved in lipid metabolism and the phase I detoxification pathway, including cytochrome P450 oxidases. Required for diet restriction- and mitochondrial dysfunction-mediated lifespan extension, perhaps acting in a ubiquitination-dependent manner. Involved in the response to oxidative stress. Plays a role in cell death.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localized to nucleus at the larval L4 stage, becoming cytoplasmic during early adulthood. Translocation to the nucleus dependent, in some circumstances, on oxidative stress.
Sequence:
MTSSSINATSSREPLIHIPNKPSLSIDPLARADRSVHLSPSFFQPGLSSISSENDDAEQRIHEATRSFNQFGHQFYESIRELSESTSAYERLKANALRRKLENTFGNDSGAATSSSSSSVFERQSDFSAFAPYKNSHFDSTQSLFQPTTSFNDRLEQIKSDFIAEHQKSMSSFSGFNTPTTALGAAFQGMQVKKSAFAPVLLRENLDTRRPGGHLISDILNRDPLPQSRNLNLNMARNVPIRLIHSTSNFDIASSSSGDSGHQDHESIVVEDADMDSPTSPCVKRSAMNFDLRDEPLTVNVESVSSTSDLPSSVSSSVNSFVYQNFDPLEFKRKIDELTASACLAVMPDANGQVDPMAIKTQLDAIKKQMEEHQTHMAEASQRLHVDSSLEDSNCEPSPSSSYDASEPSVKRLHHCTHPNCGKVYTKSSHLKAHFRTHTGEKPYECSWDGCDWRFARSDELTRHYRKHTGDRPFKCSQCSRAFSRSDHLSLHMKRHF
The following text describes a protein:
Function:
May be involved in transcriptional regulation. The function of this protein is unclear. According to one report, it is required for development and viability since mutants display defects in several developmental morphogenetic processes including dorsal closure and head involution, and die by the first instar larval stage. It may also be involved in fwe-mediated cellular competition. However, according to another report, it is not required for development or viability since mutants have no visible phenotype and are fertile.
Miscellaneous:
MISCELLANEOUS: Piragua means small boat in Spanish and refers to the small number of mutant embryos that have a hole in the dorsal aspect of the cuticle and thus resemble such a vessel.
Sequence:
MHTSDISMTQDQDVSTCRLCHHNTDPNSLNIFDDTVQFCKDVSIAEVSKSLWSVQYDRNECLSELICSRCLEILEEAFELRKGMQEREQSLQEQLKEMIKDHPKHRPGLNGNPGVFVPEEGCIIVEVDPENLAESSEEEFALGSDGEYENYDDDDEEEEEDYDEEDEEDGQNGEDVDMPLGMDAAQMAAQQSVANNANTTEARPKRAFLCQYCDLGFTLPAECQEHELAAHDPNAPYCCNFCNIKLVTRPALISHIKTLHDPDRPYVCAHCRKGFVRRSDLKKHTIVHTGVRPFTCNVCSKSFSRNTNLTKHMRIHSGVKPFVCQQCPRSFQTAVEMMRHTRSHGEVKAFQCGRCPYSFSRRDKLIAHQQVHTRRDMEQQQQMGLIPPMEGDLQQQALQAKQKAAAQTKNSRYYHCDVCDRTFQRERDLQRHQALHMDSLFACKTCNQGFNRREQLQRHELEAHGPSFTCGICCISFLHQIELENHLKVHQLQHKMAQRAQEAAILPLKMAEKAPVAMTAPLVQDPQLVRPSAAELSFYSNMIPTMNLGFYSETRPEE
The following text describes a protein:
Function:
Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity). Required for normal embryonic development.
Subcellular Localization:
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGKGEEEILPPCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMRAILTDQPMVCTPRLMYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI
The following text describes a protein:
Function:
May play an important role in the sperm/egg interaction; released during the acrosome reaction.
Miscellaneous:
MISCELLANEOUS: There appears to be no human ortholog of this protein.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome. Secreted.
Sequence:
MWGSRAQQSGPDRGRTCLLAVLLLSFSLFQLHAQDYKPSQTPPPTSDALLKPMGRVQKEICGKTKFQGKIYGGSIAKAERWPWQASLIFRGRHICGAVLIDKNWVASAAHCFKRSLKPSDYRILLGYNELSNPSNYSRQMTLSKVIVHEDYNKLHSQEKDIVLIQLHLPVRYSSHIFPVCVPDQTTKEPSDESCWISGWGMVTDDKFLQAPFPLLDSEVFLMNDQECEAFFQTPQISITEYDAIKDDMICAGDITNQKSTCRGDSGGPLVCLLDSYWYLVGLASWSGACLEPIHSPSIFTRVSHFSDWIEKKKADTPDVDPSLAPLEETAPSLIGWRNYSAGTTLEPRICTTLLSSQVLLLQSIWLRIL