lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in the uptake of a range of molecules including phosphatidylserine, lipids and xenobiotic compounds from the intestine to surrounding tissues. Possesses lipid transfer activity. Mediates transport of lipids from intestine to reproductive tract. Binds phosphatidylserine. Plays a role in efficient clearance of cell corpses by mediating phosphatidylserine appearance on phagocytic cells, thus promoting phagocytic engulfment of apoptotic cells. Vital for embryonic development.
Subcellular Localization:
Secreted.
Sequence:
MSRNFHIFFLLVSIIQVGNSADSSEITHKPAGIYVRLNQKAVDYVADLASDALPAILNNLSPPDIVTDMAKITKLHISNVAKPNLSAKFIDGKGVAYNISLASFRASAYAEISVFVWSYEGDFTAELRELSIESELHFDYNGTTTVNASVCNVTHSELSLVFPPGSSLSALQSEIKGQIVSALRDAVCTTAVEALTFVMAQKPIPPESPNYQKPEAGDPNGFSVAELGASLCQVDTVNGFEDSEQEEGNVETTVAPTPDDDNSTLTTEETQKSYWGVDLSVNHPPTFTDEDMIIGLDGGILFNGWKADSAQQLQILNKTRLDKKMVGILLSEYIPNTLFHHIYMYDLGNFKHRYTPSSLPKILQKLSKAVCSKCYVEVSANLTEQPILQIDAHLGARVQLSGNVSIMFHGREQLHDVLHANTKLHVTLKPTVRHSRIFGDVSLTNVDVNVFDLGLGGPLAAPIEKLFSFVVPRVLWPQVKKRLRFAMNRRGVKLPIFCGVELEHTELDFVDHAVLLNTDFSFDLPLFLAKFKKYLDAKSKINPNLPKYVII
The following text describes a protein:
Function:
Required for normal Golgi function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MENGEPEKVAPASFSSANPAKKKIDKLIASKVHNDPAFAELMDYVSPIVSDIDIHTERRLMRKLEQRELELNKEYLKEFEKVNEHVQKFSDKVTAMHKICADLTDQIQQNKEKTQDLLNKTSALQNRKKVLELKQKTIDDFLAKFSLTEAEEKALDGNADGRVSSDFFPALDRAHSIYEQSKQLLRTCANHSAAMGVMEEMSKKMEAAYDVLYRSIQRECRVLSTEMVEVKGVIAESFAALKDRQILLKYALDDYANARKNNAMRAFSDILTRGAGGGKPLEVLSHDPLRYTGDMLAWIYECIGSEKDLLLLLLSKCPPEMIREHEQRVLASISAQLARTFKVRVEQTLTGEHESTLLYKLVSILAFYATKIEPIVGADSDLVQTIDELQQLTLNIFFSGLNQTVHKILTKMGTPDYDLLPVQAVHQSLMLLKEVLDVHDSTSSGGDESKARFDKMVASVLDPLYRSIQLATTQLHSPVDISVYTLNCLSSIHSLLILYPFTDKRIEVALALMSGHEDTLISEEASAILSSTGLIPIYQKAMAHNQSQGPLSSISEADAATVKRALESFDHFLAQPHFGRIDQVARISNIKVRERVHTRTMENVVAAYSIIHSRLVDPFNKYEGLEAKTVEQVRDLLK
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MSDATPSSSEAPTPSGQCSRLRPRSKNSTAPEPPAPKLTDHTDKLFIEQLRRTTFPFEFQNKLDSRWTIGDMLKTIHKTLLDWLEVKQPTKEVIEDPAKFKSYLKNLNGKIRASHHRPLPEAMELWMKEKCSAKHASRICYFSRELSIGDEKLLNNYRPHSAETYGETALNQLLSICEELEVGTDDIFADLGSGVGQTVLFLSAFAGVKKSIGFEIMQYPSKCAELNRSHFISLMKHLGKAPLEIKLIHGSFLDAEAVELITSEATLLFMNNVKFDPPLMLNSENLFKKCKVGTRIISTSEFVNRGRSPEASNAWTSQLASITSTKKLRSVSNNVSWTGLTQQFYLTTIHSALPTPQPTDQ
The following text describes a protein:
Function:
May be involved in trafficking events within the endosomal system.
Sequence:
MGGIFSKGYLPELPNGSLIKLGIIGLENSGKTTLLNKFIDASSKKSIASVLISTGVYIESIIFKGWEIFAGDLLYPNYISKIYKPYLLGSDVIIFMIDSSDIHQMTEAKNQIDLLIQEQCINSSVFLVMANKQDQKRCVSIHQLEQYLELYRLTNPWKCLPLSLIQEKGIEDLIKWILENTVVRKTYNNQLQTLQ
The following text describes a protein:
Function:
Odorant receptor.
Subcellular Localization:
Cell membrane. Membrane; Multi-pass membrane protein.
Sequence:
VSLQELMQPESGANGTVIAEFILLGLLEAPGLQPVVFVLFLFAYLVTVGGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQRMLVAASWACAFTNALTHTVAMSTLNFCGPNVINHFYCDLPQLCQLSCSSTQLSELLLFAVGFIMAGTSMALIVISYIHVAAAVLRIRSGRKKAFSTCGSHLTVVAIFYGSGIFNYMRLGSTKLSDKDKAVGIFNTVINPMLNPIIYSFRNPDVQSAIWRMLTGRRSLA
The following text describes a protein:
Function:
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MVRFARPFWIEHEGCPIFSVDTSPDGKKFVTGGGDGKVRVWNIEALSDETVQPKLYGVIYVSTLPVNICRFSPDGTILAVGNDDKIVSLWKSEGMKDEFEKDEEGNVYCEEYLNIGNLRGHVQEITDISWSPDGKFLASSSADNTVTIWDITKMELKDVFRGHNSSVFGVAWDPINKYIVSMDVQKVVIWDIKTLEEIARIEDVYKKANHGNFSSRISWSPDGMNIVVGSAVSKKRHVALLIRRNKWTVQLLTAHLNEVICSRFSPEIYTYTKEGGKKKSAFCTFATGGMGGDCCIWENKKDIDSICLVTDVFDNSIQDIAWANQGKMVLLVGLEGFLACIEYSNEELKGEVLKGKAKTKLLNSIYQREVEIAELERDKRKEMKTKLSEEESEELLNPEDEKQKIEEENEERKRRITDDGLTEEERKQLEVFDKIKQSKELKKNNNKKIDIKRPEIKKNEPIKSNGITTNPLIKKQEIKDESREQQLQRERAERLEKIDKMEFNKNIKKLEKIDQLEEKIKWLNERIEKIDWEKISQKVHQLELSINEEKQFILQQPVVKPLSCNSRDQNGSGVIIKGIPTTYGKKMFTCLKCIKIIGDIMYWEAALPYELVVLNCYDNKVITVSKENIIILLDSFSGSICNVPLMNNGIIYNAFYNEGYLVVLECNGIVKVYNNQFELIKVVNIEMLLTQLSNKKPTNIQFINHKNIIVSFDNEMDVLVHQGSYKIIRCLIQEDEKRRNISIYEKRKVELEIIVMQLFNEWDEKVFKQTMNKYIDALKQTNDFGRAKVIVQTLNRLKMKWPSNESCINLNQQEVIEWLTPNGMK
The following text describes a protein:
Function:
May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis.
Subcellular Localization:
Cell membrane. Cytoplasm, myofibril, sarcomere.
Sequence:
MEDAVYRISESCQVGRRLDDSHQNFRSQFKWARKSSVTAGCKAESYSVADSDGSVSPSVASLPQQASGSTSPCSPSSFSGTRHPVSTLKKWLSNPVRKLSSGARTEADKVDKQIFRSEEKQPPVLFSHSETRQSSLKTHDNQSSLTSGNMVRFQDGQRSYIYILGFAFLTCLFLMTVYFCVQEWKNGLLNPAAPSPSPLSHQNCLCERQQSRDSQSLSQKSSSNTLPGDDSGTAADDSASQGSAAVDSEEERSVALEKSLYVLTELVETERLYVEDLGLIVQGYMSMMSSQSVPEDLRGKDRIVFGNIQQIYDWHKEYFLGELEKCVDNPDSLAKLFIKHERRLHMYVVYCQNKPKSEHVVSEYIETYFEDLRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYSKAGRDVEELQNAVEVMCFVPKRCNDMMNVGRLRGFEGKITAQGKLLQQDTFSVSEQEAGLLSRARERRVFLFEQLVIFSEPTDKKKGFLLPGYIFKNSIKVSCLGVEQPSEEDPCCLVLTSRGTNSSVTRFIMHASFPETQQAWFNDVVQILETQRNFLNALQSPIEYQRRESLSNSLGRTVKSPAVPPSGQRLHSSESMDRPHQPCLLSYNNSLPSLHSPRLQPSSKTSNQCEGTFRAAPFSSFQQLSMRSKVKPDCASCTSLSPCSHHSHKGVSASFQTITFCDAASYSAHRPHSLDQLKETEQP
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase playing a central role in histone code and gene regulation (By similarity). Involved in ubiquitination of histone H2A. Plays a role in the formation of the male-specific genital sensilla (simple sense organs) known as rays. Required for normal migration of the hermaphrodite specific neurons (HSN) and for extension of some neuronal processes. Represses vulval fates in hypodermal cells that do not normally contribute to vulval development.
Sequence:
MDDSPGPSTSKSARDKAENAEENTSDSSSDSEVSSASEKSEESRPSSEKKKVITRVIPVRPPTRDKGHRVNLLESGNESETKSLYQRAKEGIPSYKGKPEIKLPTTSEQYYDLEEVLMNPARMEGRELTLNAYDAVRNKYNVLPGKSVCEADLQKVIGSFSCDVCQELIQGSIMTKKCGHRFCDQCILVAFMRSGNTCPTCRQNLGSKRELQQDPRFDQLIYQVVESRSIVGRMMAENREHEKDVYFGRKGYIEGGSDWNKRYGIDPNSKLKAPRPLKSAGRKKIRWFHESDEDGSVRKVMESKKGAPKEDDTNYLENDKEGTSVAAEKEVLEEGEMDFPIEIKSSDEEQTDLDDEEESMLDSDFEISDNEDVSKPSCSTSKKTTNRSRDSSESDNDSRDNELQKKKRKMKRKNVPKTDGSDVSNESFDEDASGEVVATKLIKESKKKPCGRPKKKFAPELIEGDIPTPSEDSLTSSDEERDDNAADPYAFVFQKEFNRDPRRDGHPEKDKLYNFDFMIDMNHQVDRKFEKDGEIHVISDDSNSEHESDEAEDRESSIDSEHEKEISKFLSHRQPLPNPTSVDDDCQVITVVKKDVKQSAITSKPGETSPDSSSKIEEKPDKVSEEVSDDEMTPEHITADKGTDTFLNNIMEHDDEMYGGYLFRPGDTGISRPKVQRAPGTNRLSMNVCPEAVYVVYPQPVLKEGKKKLVIPPEDYEISSDETVTLSDSEETSPSAEMEQSETSEAGPSTIIKTSGTERETQGSSSPSEPSTSRDRKMHKRKLDTRRRKLADDSDLSDFDVFSIDGNELVATGKPIIKHKVFYDSANRMPSKSNLDFTGRRNAREIPMEEISRLAEEQVAHEEYKIHRRRQVVLEAVEAASKKLNVYVDTTEEEEIEEEETPEEEVVKVASPTAPIATENPTTSTAPFEEGVAMKETPIEEIFFDPDEPCSSAQAAQRELIIERVGKEQQIIEDSLEQNRKPSSKTVKESESREAQEPRIEKDEMESEQQKKDADNPTVEVDKESEASSSESDKSDFEDETLDAQSKTVKISLKHEKTVSDEEIEDFDTKFGEFVATADAKMIKRTIGEYVSTEFLKLVAQQPAVTDEVLALGFCVRNTDQEFSTIKETGKRTNKNPDDVRLESMVKNFRESFAAKHRPVPRKLPTNIERMYIERAHMVKYKHVVDMEPLHMKILIALQKQQIAATCANLSQPVTVTPEEHAEQVQLLHNLQNPSILRPLLNNPQFALTLHKAQQQAIQQQRAQQKAQTQKELAARQAEQARVEELARKRIAQEDAEKALRQKGEQMSNVSGIPVSSDQNAQSSNAQQTGLIENQTTTTNSDSLTRPNTLADNSHLGESQQIPVIESIQSSTSEALKESENYKDMPILTPASTVSSKSSAPATRRPSRPCSSYDRPSSPSVVIRERLGSDGALINRPPNRCNIDKSRSRSPISRAPVETVRINDHGQNETILAGNITHTVETTILEEGTSIGQDSTIRYDGECSTTQYIDKTIDLDNSKNGTNVDEEQSNVLKLRENDLNREMLRYANRYHPSTMLAMGNLSINERHNKVQQVLASQELQDLIARHTSGAVSQTQVEVVGGEGVCAGTSDAIGETDEDDDVEEEPEFTVDQLELAKKILKQRQGLESSEDSDSDEDMVYDNVDGSVIRRAPHKKRETRKKKNIFVPNIPPKIRRKYVDKKIEMERAKYRARIKSQKMASIRIAVPQKPTQQFATPQQPVRGPGKHSAAAAARATPKPKKAKMSNVQMSIVQPPLPLHQLQGHMSAPTKITAVPNVAAGFHQNQQQLYSDMAQAPQSTPIRTTPQPGTGSAPQAQTPQSHLAQLGQFVNGANQQQAPQQQGMYTAAQLQAMQAAVAQTAQAAQAAYAAEAAYQAQVAQQARAAPPQQLVQRQVPVGHPGQVNVPMPAQMLNQGNPQMAVNPAQAQMMDERRKMEEVNAVYHLMQSRGQFPPTNQELFQVQFAQAQADLRSAAAQAAQAAQAQAQMTNMRAQAEAVARQQAMMKQEQARAQAAAKEAARLKAETEAAKAKVQAEAEARRKAEQEMRVRQAQAAQTQAAQAQAQSQAHAQNQAQTQAIVEIQRMIQSGQPLSMQQMQQLQQMSQVQMQHAQQVQQMQQMQMQQLQMQQFAARMQQGTPKPAVSQQAVQQGMPAGIQGMPTGMGMQQLQGLGMPGMQLPQQAGQSQQTSQAQQQQLFMQLQLQQQQLMQHQLQQQLQMQQHQQHQQQQQQIQMQQQQQLAQQGLVPNVSSAWLQQQAQLAQQQQQVVQQNLLMRVPSAQTPVAPRAPTVAPQSVVQQAPAPATPIAISVATTQVTRPETVEPFRSISSGTGTGTERINNNVELELWPTNGYSEKKRKEGSQASPIFGASAGDSTFYHVACLIRSRSACNADDVGSLWVLRLEDQTLLQFQLQQTLAEAQRFVGKQHLVIFYDDVMSGEVQQSKEYVINREFKPSNRQIPN
The following text describes a protein:
Function:
Plays an important role in ciliogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium. Note=Colocalizes with sas-4 to centrioles throughout the embryonic cell cycle and in sperm. Localizes at the base of mature cilia.
Sequence:
MANFTTENELEDILHQMGHHIHDKNQFATFKNEIDNLLDRELCLSDADEDVMNESLFASLSVDPAAQFIRQERNFPTENLNIQSPIVSRKRQGKRFIYENVELQSDFDDESSNEYPERNLLVDRAWRSIHRAMETCNGATETLKSISLDGSDIQERSSVDDEENIAESVSVGLSTETEQSELQKSSRPEKEVWTRNVLSLEPGRAPKKYDPVTRYHFYKSEWDRHPAPGEMRRLSLRWKVREFMLRHDVPRLNENNEDWKANHDKDWSPRPYID
The following text describes a protein:
Function:
Regulator of adipocytes that acts by repressing FOXO1 transcriptional activity. Acts by promoting acetylation of FOXO1, both by preventing the interaction between FOXO1 and SIRT1 deacetylase, and by mediating acetyltransferase activity in vitro. Regulates insulin sensitivity and energy metabolism.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Note=Imported into the nucleus following phosphorylation at Thr-93 upon treatment of cells with forskolin. Probably shuttles between the nucleus and the cytoplasm.
Sequence:
MGGPTRRHQEEGSAECLGGPSTRAAPGPGLRDFHFTTAGPSKADRLGDAAQIHRERMRPVQCGDGSGERVFLQSPGSIGTLYIRLDLNSQRSTCCCLLNAGTKGMC
The following text describes a protein:
Function:
May have a vacuolar function.
Miscellaneous:
MISCELLANEOUS: Present with 2180 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Bud. Bud neck. Cytoplasm, cell cortex. Note=And found in the cell periphery.
Sequence:
MSSSSLRVLAIGNNPNILFYTSRFQLAKNIDLYHVNDSKSCQFEIETEYYGKDRFELENHFTSIEHLTEALSSKSSEAVFDIIIMSAPSLQELSSLASKLTSIIDSNTKIFLESSGFIQLEPFVKLSMESPHVNVFSILTDLDIRQIGPNHFKHFPSTAKENTIYLGESKSSTEKYSSGVITLLTTFEKLFAKLFSNIKINLCNFSSIEFLSQQWKLAISRICFDPLLIMFEQENPSDLDQQIIAKPLISGLVTEIITVAKTMGARLNSSHDNENSLLSLWKNSYHSTNKPPALVYHFIHQTTPLNIDILLLQTILLADDFGIKTPYLEFLYSVLSQFERLNSGKSKWFIRSDEKTQILQSLQKSQKNESALQTQITSLQGQISKLRQELLMQAKQHEMETNELKEKHQVALKAQAQAQAQAQSQAQTSIEALTPTEATNQSDTNEYKATGTPNLRDIEDMALYSVNYGDSPVRSPPPVVSSQPQMNSPLSSHSQTFGENNGTNDKLLQERELQLRKKELELQERELEFQKRALQQQRFNNSNNSIPRKPSFPQLQQSANVRSNSRGMHGTNGAMSQPASAGNFVDPISSSIAAYDPQQPPSLPLQQPQQSVQVQPFHSHSIKPTSRKNRNSNMPNIGNPSSINMSDFGRPPNNSSQTRLNSMPTHSIVNQNRLRSQQSKNKLNMPHATNPNNTFNQVPAPSLNNHVPTQRQFSSSTMIEVTNNNNKVNNSSSNPDISTNSVVHNAMQFTNTNNNTSSTVDINDPKNIAPPPTTSVSAPSTPTLSSSSQMANMASPSTDNGDNEEKNGGKKKRFGLFKKKNKSKK
The following text describes a protein:
Function:
Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Sequence:
MEIRIMLFILMMMVMPVSYAACYSELSVQHNLVVQGDFALTQTQMATYEHNFNDSSCVSTNTITPMSPSDIIVGLYNDTIKLNLHFEWTNKNNITLSNNQTSFTSGYSVTVTPAASNAKVNVSAGGGGSVMINGVATLSSASSSTRGSAAVQFLLCLLGGKSWDACVNSYRNALAQNAGVYSFNLTLSYNPITTTCKPDDLLITLDSIPVSQLPATGNKATINSKQGDIILRCKNLLGQQNQTSRKMQVYLSSSDLLTNSNTILKGAEDNGVGFILESNGSPVTLLNITNSSKGYTNLKEVAAKSKLTDTTVSIPITASYYVYDTNKVKSGALEATALINVKYD
The following text describes a protein:
Function:
Putative pheromone receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVSRDLIQGICFLSQTAVGLVGNSFLLTVHVFLLPQLHQPKPTDLIVSHLALVHTVMLLTRVVTVTVSALSLRQLQTDVGCKMFAFVYRATRGVSMGTTSLLSATQAITIGPSHPSWTRLKAQMSKRIFPACVSIWFINMLVEANLLVKMVLSPNLTSRGNSFHDNYCVVSRISTYLSALLQGPLLTLMTVRDILSLGLMGGSSGYMVLLLLRHSQRVHRLHGHHPTSRTSPETQATQTILLLVSCFMVFCSGDFVLSLFLGTMLRNDPFLLVISQFVVSGYPTISPFVLLNSHRQVTKLLGSFLGKKDPIP
The following text describes a protein:
Function:
Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MASFRRTLSPAYPDRQYLNGSFSVSSPSHKLPSSNAKYSSPLPELVAAFLRLAGGVFTRRHGRKGQWRRVVVRCVLCFFVGFLLGMFPFGHVSETVRSHEFSFEMKPPPLPRAANNAQQLLLEDRVLRNRYFELLNVKLSSSHIYQFSTCTAYNHDVFMFLECSRFGTWPVAMLAPSKNKAILEGPVCNASQVIGWHTNEKSKRLRRFHVDMSGFAFNSTILWDPKRWRRPSSNPVRQLDTVKEGFQETTFIEQLVEDESQMEGSPPGCSKILNWHLHLAANNIVYPKGWVLQKNLDAVIPVK
The following text describes a protein:
Function:
Plays an essential role in cuticle biogenesis. Required in combination with bli-3 for correct formation of cross-links in cuticle collagens.
Sequence:
MRRLHRNLSLLFLICILNEYRIESQTLSPPITDRFKCLTNGCCDHHEWCRFWASIGECNANKDWMTENCQLACGTCTAPAAPLLPVTTTASSFNGGGFVQTTTQSSGPTTTITIPPSSLTSVTSCERVKDSIAQASELMSISRLINPVEDNFGRNMLSIDDITRSVPTGCVPQLSDVGVDCRKSLCYHLMYRTLDGTCNNLEKPMQGAAFRRFNRHFPAQYDDGKGEPISSLNQSRPSAREANRVMLSSAQSVVHDKFNNMMMQWGQFMSHDMSKTTLQPSANCKTCDPVPSKCMPIPIGEKDPNLGFKSKQCLKVSRSAPICRVEPREQLNENTAYIDGSMIYGSSLKDLHKFRDGRTGFLRVTRFNNQNVLPFDQSKCANKDKCTASFTAGDIRANLFIGLSSLHIMFAREHNRIAQKLTELNPTWSGDRVFQEARKIVGAQIQNVLYKEYLPKLLGVSFDKVIGPYKGYDTNVDATIANEFTTSAFRFGHGMIEEFYKRVDLSGNNITHGGFFFGDGVFKSGKILFEGGVDPIIRGFMTTAVKRPHRMTPAITEKMFGSTDLGSLNIQRGRDHGIPSYNKMRQFCGLKSANTFDDFADMILDRNLRAGLARNYNTTNDVDFYVGSMLEDPVIGGLVGTTLSCAIGEQFKRARDGDRFYFENPGIFTRSQMEEIKKSSLSRIICDNADNFELVSQDAFLLPGSNLTPCSKIPKMDLSKWRAL
The following text describes a protein:
Function:
Endonuclease RNase P responsible for the 5' maturation of tRNA precursors. Preferentially cleaves at the unusual cleavage site, but also able to cleave at the classical cleavage site. Also involved in the maturation of mRNAs in mitochondria.
Subcellular Localization:
Mitochondrion. Plastid, chloroplast.
Sequence:
MLRLTCFTPSFSRACCPLFAMMLKVPSVHLHHPRFSPFRFYHTSLLVKGTRDRRLILVERSRHLCTLPLAAAKQSAASPSENLSRKAKKKAIQQSPEALLKQKLDMCSKKGDVLEALRLYDEARRNGVQLSQYHYNVLLYVCSLAEAATESSPNPGLSRGFDIFKQMIVDKVVPNEATFTNGARLAVAKDDPEMAFDMVKQMKAFGIQPRLRSYGPALFGFCRKGDADKAYEVDAHMVESEVVPEEPELAALLKVSMDTKNADKVYKTLQRLRDLVRQVSKSTFDMIEEWFKSEVATKTGVKKWDVKKIRDAVVSGGGGWHGQGWLGTGKWNVKRTEMDENGVCKCCKEKLVCIDINPVETETFAASLTRLACEREVKANFNQFQEWLERHGPFDAVIDGANMGLVNQRSFSFFQLNNTVQRCQQISPSKRLPLVILHKSRVNGGPATYPKNRALLEKWKNAGALYATPPGSNDDWYWLYAAVSCKCLLVTNDEMRDHLFQLLGNSFFPRWKEKHQVRISVTREDGLKLNMPPPYSIVIQESEDGTWHVPMSVEDDLQTSRQWLCAKRSKTP
The following text describes a protein:
Function:
Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA.
Subcellular Localization:
Host nucleus. Note=In the absence of DNA replication, found in the nuclear framework-associated structures (prereplicative sites). As viral DNA replication proceeds, it migrates to globular intranuclear structures (replication compartments).
Sequence:
MALKGPQTLEENIGSAAPTGPCGYLYAYVTHNFPIGEASLLGNGYPEAKVFSLPLLHGLTVESDFPLNVKAVHKKIDATTASVKLTSYHREAIVFHNTHLFQPIFQGKGLEKLCRESRELFGFSTFVEQQHKGTLWSPEACPQLPCANEIFMAVIVTEGFKERLYGGKLVPVPSQTTPVHIGEHQAFKIPLYDEDLFGPSRAQELCRFYNPDISRYLHDSIFTGIAQALRVKDVSTVIQASERQFVHDQYKIPKLVQAKDFPQCASRGTDGSTLMVIDSLVAELGMSYGLSFIEGPQDSCEVLNYDTWPIFENCETPDARLRALEVWHAEQALHIGAQLFAANSVLYLTRVAKLPQKNQRGDANMYNSFYLQHGLGYLSEATVKENGASAFKGVPVSALDGSSYTLQHLAYASSFSPHLLARMCYYLQFLPHHKNTNSQSYNVVDYVGTAAPSQMCDLCQGQCPAVCINTLFYRMKDRFPPVLSNVKRDPYVITGTAGTYNDLEILGNFATFREREEEGNPVEDAPKYTYWQLCQNITEKLASMGISEGGDALRTLIVDIPSFVKVFKGIDSTVEAELLKFINCMIKNNYNFRENIKSVHHILQFACNVYWQAPCPVFLTLYYKSLLTVIQDICLTSCMMYEQDNPAVGIVPSEWLKMHFQTMWTNFKGACFDKGAITGGELKIVHQSMFCDLFDTDAAIGGMFAPARMQVRIARAMLMVPKTIKIKNRIIFSNSTGAESIQAGFMKPASQRDSYIVGGPYMKFLNALHKTLFPSTKTSALYLWHKIGQTTKNPILPGVSGEHLTELCNYVKASSQAFEEINVLDLVPDTLTSYAKIKLNSSILRACGQTQFYATTLSCLSPVTQLVPAEEYPHVLGPVGLSSPDEYRVKVAGRSVTIVQSTLKQAVSTNGRLRPIITVPLVVNKYTGSNGNTNVFHCANLGYFSGRGVDRNLRPESVPFKKNNVSSMLRKRHVIMTPLVDRLVKRIVGINSGEFEAEAVKRSVQNVLEDRDNPNLPKTVVLELVKHLGSSCASLTEEDVIYYLGPYAVLGDEVLSLLSTVGQAGVPWTAEGVASVIQDIIDDCELQFVGPEEPCLIQGQSVVEELFPSPGVPSLTVGKKRKIASLLSDLDL
The following text describes a protein:
Function:
Component of KG oxidoreductase (KOR) that catalyzes the CoA-dependent oxidative decarboxylation of 2-oxoglutarate (alpha-ketoglutarate, KG) to succinyl-CoA. Methyl viologen can act as electron acceptor in vitro; the physiologic electron acceptor is unknown. Is involved in the alternative TCA pathway that functions concurrently with fatty acid beta-oxidation. Since a growing body of evidence indicates that lipids (for example cholesterol and fatty acids) are a predominant growth substrate for M.tuberculosis during infection, flux through KOR likely represents an important step in intermediary metabolism in vivo. KOR-dependent decarboxylation of KG also appears to be an important source of CO(2) in M.tuberculosis metabolism.
Miscellaneous:
MISCELLANEOUS: Is extremely stable under aerobic conditions.
Sequence:
MDPNGSGAGPESHDAAFHAAPDRQRLENVVIRFAGDSGDGMQLTGDRFTSEAALFGNDLATQPNYPAEIRAPAGTLPGVSSFQIQIADYDILTAGDRPDVLVAMNPAALKANIGDLPLGGMVIVNSDEFTKRNLTKVGYVTNPLESGELSDYVVHTVAMTTLTLGAVEAIGASKKDGQRAKNMFALGLLSWMYGRELEHSEAFIREKFARKPEIAEANVLALKAGWNYGETTEAFGTTYEIPPATLPPGEYRQISGNTALAYGIVVAGQLAGLPVVLGSYPITPASDILHELSKHKNFNVVTFQAEDEIGGICAALGAAYGGALGVTSTSGPGISLKSEALGLGVMTELPLLVIDVQRGGPSTGLPTKTEQADLLQALYGRNGESPVAVLAPRSPADCFETALEAVRIAVSYHTPVILLSDGAIANGSEPWRIPDVNALPPIKHTFAKPGEPFQPYARDRETLARQFAIPGTPGLEHRIGGLEAANGSGDISYEPTNHDLMVRLRQAKIDGIHVPDLEVDDPTGDAELLLIGWGSSYGPIGEACRRARRRGTKVAHAHLRYLNPFPANLGEVLRRYPKVVAPELNLGQLAQVLRGKYLVDVQSVTKVKGVSFLADEIGRFIRAALAGRLAELEQDKTLVARLSAATAGAGANG
The following text describes a protein:
Function:
Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.
Sequence:
MLRLLAFFATLCAVANSCPTILSKAQWGGRAPTCRTAMATPVTYVIIHHTAGAACSSQSSCITQAKNIQNYHMNSNTWCDIGYSFLVGEDGNVYEGRGWTSVGAHAPNYNSNSIGISVMGTFSNINPNTAAQNAVKNLISCGVTRGYIKSAYILKGHRNVSATECPGNTFYNTVKTWPRFQA
The following text describes a protein:
Function:
Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-2 affects the body shape.
Sequence:
MKSQTSGYVDPQTEEYDESREKSYQVLIAVSGVLSITSLLILVLFVPSMYNYVDNISRFSRRDFEFCQASANDLETEMMSVREGLLRGRNVTKRAAGYGHYNPSMLAADSPQFQECPACCIPGERGPSGDSGLPALPGAPGPDGAPGRPGTTPNASCIPERVFEPPPCLPCPQGPRGVPGHPGFPGDPGEYGIGGRPGSDGMPGKPGDPGLAGPIGPPGESGPIGDKGRTPEAHVIPGPPGDSGLPGPWGPPGSAGMPGEDGYAGTPGEKGWPGPPGAPGPGGMPGPNGPTGEQGPSGTPGTCVCQDTEVVMNDEKGRVPAPRDNVAPGATGGSYEPQGGNDAAAPSAISQSQNRRIRKW
The following text describes a protein:
Function:
SUMO E3 ligase that plays a role in viral gene regulation and is essential for viral reactivation. Disrupts host G1 cell cycle control thus allowing viral transcription and translation to proceed at the early stages of infection. Catalyzes its own SUMO modification as well as that of its interacting partners such as host TP53 and RB1. Regulates viral gene expression and reactivation and may mediate the SUMOylation of viral promoters in the low methylated 'Lys-9' histone H3 (H3K9me) region which results in a diminution of viral gene expression after reactivation. SUMOylates also host histone lysine demethylase 4A/KDM4A, an essential step for complete enrichment of SUMO-2/3 on the viral genome during viral transactivation and reactivation.
Sequence:
MPRMKDIPTKSSPGTDNSEKDEAVIEEDLSLNGQPFFTDNTDGGENEVSWTSSLLSTYVGCQPPAIPVCETVIDLTAPSQSGAPGDEHLPCSLNAETKFHIPDPSWTLSHTPPRGPHISQQLPTRRSKRRLHRKFEEERLCTKAKQGAGRPVPASVVKVGNITPHYGEELTRGDAVPAAPITPPYPRVQRPAQPTHVLFSPVFVSLKAEVCDQSHSPTRKQGRYGRVSSKAYTRQLQQALEEKDAQLCFLAARLEAHKEQIIFLRDMLMRMCQQPASPTDAPLPPC
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGSRWSSISLPKYDRGFYLSLLPFASLIFAIFLALTYVIASASYPSISKFGVKLFTENVWSPSEMGEEFVRYGLLAPLYGTVITSSLAAIIALPLSLSTVYLVEEMTNSRVKELLSTAIDLMAGLPTVLYGLWGLDVMIPFLRENLMKPLHSALPWLPLFSCEPLSGASILSAGILLAIMIIPFMHSLIQDAYRSVPWIYREAILSIGANRYEYYKMMISLIKPAVFGSLLLGIGRASSETVAVTLVIGNAFNISFCIFAPGYTIPSLIANQFSESNFYPYMQSTLYAGGLVLLIVGALFSALALLMMRKVRKLYG
The following text describes a protein:
Function:
Catalyzes the Claisen rearrangement of chorismate to prephenate. The joint presence of this enzyme together with cyclohexadienyl dehydratase and aromatic aminotransferase in the periplasmic compartment comprises a complete three-step chorismate to phenylalanine pathway and accounts for the so called hidden overflow pathway to phenylalanine in P.aeruginosa, in which two possible routes for it exists, namely either via phenylpyruvate or L-arogenate.
Subcellular Localization:
Periplasm.
Sequence:
MRPSFASWGLLALLLLQGPLLQAQPLSPALQQLLSLSSQRLQLADQVAQSKAQSGKAVQDSPREEQQLQMLAGQAGSHGVGAEQVRLLFAAQIEANKLVQYRLLSRPLPDAGQAVDLERIRSRLNQLNLELLRGYAPALAELRVDDCRPRLNQALQRQVRVDRLDELHAIALSRAAGDLCHWAEL
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MNKFLIALLVLATLAVSFSQEIGVSILKTDTPKGECKGKTASIGDYISLKYVGKFEDGTVFDSSEIHGGFSFNFTIGERKVIPGLEIGTINICEGEKRSIKIPYQLAYGENGIENAIPPRTDIYFDLEVVSIEGAPAQPFYYQLIPSVGTIIAFSMLAGFIVLVKFIIKRYPDESNSKKPAPGKPKKTKAAKQN
The following text describes a protein:
Function:
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.
Sequence:
MWCNGIMRKIRLIIPLLMVIFISSLSACGFKPRSPNDIPPQLRILYLDAPNPYDPLVVQLSRTLRALNVHLTQTREAAPVTLRIGHIGWETVIPTILYSSNATTYSYTLSVDFVVETQDGRTIKGPANLTLTRSLLQNANQVYTPNATRLMKREMTRTMVTLIYNYLVTGLAPPPPRVREKGA
The following text describes a protein:
Function:
May be involved in the generation of recombinogenic substrates for the subsequent action of RecA.
Subcellular Localization:
Cytoplasm.
Sequence:
MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLLRLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSPAVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSGKTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGTFHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGFWKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLLEQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFILDFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYPYDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQSFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKALAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLEKGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTVYVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTANRSRFLYPLLQKARQPLHH