lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates. Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation. May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway. May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins. Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols. May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. Nucleus inner membrane.
Sequence:
MPSPRRTIEGRPLGSSGGSSVPGSPAHGGGGGGSGRFEFQSLLSCRSGADPACARLRASDSPVHRRGSFPLAAACPAQVAPAPPPEDAGMNLNPSFLGIALRSLLAIDLWLSKKLGVCAGESSAWGSVRPLMKLLEISGHGIPWLLGTLYCLLRSDSWAGREVLMNLLFALLLDLLLVAVIKGLVRRRRPAHNQMDMFFTLSVDKYSFPSGHATRAALVSRFILNHLVLAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVAFGFFLGYMQYSIVDYCWLSPLNVPVLFVLWNQQ
The following text describes a protein:
Function:
Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAVVDVHRFAESITCHAWSPDLSMVALCPNNTEVHIYKSLSQDHWERLHVLQKHDQIVSGIDWSSKSNKIVTVSHDRNSYVWSLEGAEWVPTLVILRLNRAALCVQWSPKENKFAVGSGAKTVCICYYEQENNWWVSKLIRKRHESSVTSVAWHPNNVLLATTSTDGKCRVFSTFIKGVDTKDSKAGSPAETKFGEQILQLDLSYSWAFGVKWSPSGNTLAYVGHSSMIYFVDDVGPSPLAQSVAFRDLPLRDVLFISEKMVIGVGYDSNPMVFASDDTGIWSFIRYIGEKKAASSNSSYSSQFSEAFGKFYGSQSKSTTANDASESRGGVHDNCINSIVSLSKAGSPKVMRFSTSGLDGKVAIWDLENMEQELGNQF
The following text describes a protein:
Function:
G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5. Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages. Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity).
Miscellaneous:
MISCELLANEOUS: GSK682753A (8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one), an inverse agonist, selectively inhibits the constitutive activity of GPR183 with high potency and efficacy. Specifically inhibited by NIBR189 ((2E)-3-(4-Bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2-propene-1-one).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Subcellular Localization:
Nucleus.
Sequence:
MECIEAKALKSSFLKEFGSKSTQQTLFEDLWCVAGIDNVVNVSPDEFSVDDLLDLSDKDFNNSDGGCFEEYSEEDEEKDSMISSHFSSTGDLVSLPAGEIHLPVDDMENLEWLSQIVDDSTSEFSLSFPPTNLKKTVKFTMNRHEPVRPVIPSFTVLGLSYPVPRKCRSKRSKKTGQVWSGLTESSMDTSSSYDSSTTMHSLNPVQIIQSIFNFQTPPTKKHKKNTGTAIASDLNGCITQRRCTHCQVQKTPQWRTGPLGPKTLCNACGVRFKSGRLYPEYRPASSPTFSGDLHSNSHRKVLEMRKKKETEPDFSFGFDSFSC
The following text describes a protein:
Function:
Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Sequence:
MALALDELAIGLVREFLARKGFKDSLDALDREVPRTDSSLTKKSALIRGLRAETLAKKYKEQNLSSLLETIVKYLADKTGALVDTQTTLTRVSSGQEGHGSSGGVRDNNSDGAMASAISQMSLSSGLNIGRTVTGHHASVAAPVSTRPPRTARGMRTSASGASSGPGLGDPGTSGLSQASRPRAAAPHSQRAGFSANRRPGLVSRPGPDPDDLVLDDLGLEDVVDVGIPSTRPTRAIPRAPSATTINRLVASGGVRAARPLSGQFAVALKKAIFGRLDARFVPAWLRQNLAFHPHPDLAYGLWQQEGGPCGVLAVVQAYLLRELLFETHVGLQPSPAQRMEALTHALTRMLWRCGEGRECVVAVLGTSEAQGLPPTWARDGVLERVHTVECADHDACLVAVRQALLDWCAEQAPGIILILISAILSRGLDRLLADRDVDAGPLLGAHNYCTQDMVNLLVTGRATSNVHDGEVRLDDQLVLKGIDDPADFGLLSLFEHFDSCRVGVHLKRPTFPIWIVCAESHFTVLFSRERQVQDWADDEDFELCYYDQLARLEEHYVLRIGKAKDGQDGQDFPSGGRRAPYIGHNFHSRRLSALFFFSKSFFACR
The following text describes a protein:
Function:
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Miscellaneous:
MISCELLANEOUS: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKLLVIDFKEKIKYEDAWNFQRKLHDLRVNNIIYDTLILLEHFPVITLGKFGNESNLLKRKEELEDIGIDFLRVDRGGDITYHGPLQLVGYLIFRVEGVKNFVLKIERSIINVLNEYGIEAKENLKYPGVWVGDRKIAAIGIAIKKKVSYHGFALNVSNDLTPFSYIIPCGLKDKKVTSILKEADFSPSMEDVKKKVCLSVVREFGFDSFKVFNFSSYKELSNFDMLLEDQ
The following text describes a protein:
Function:
Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Subcellular Localization:
Mitochondrion.
Sequence:
MVLSTRLITRFKLRRTSRCWGPLQPPARPDFSTFVSCQNGLPETNPKTEISNQSTSLLKIINQQILASGPISVPVWMKLCLHHPTLGYYSRTDRSNQADPFGKQGDFITSPEISQVFGELIAIWFISRWQAAGCPRRTRIIELGPGRGTLMADIIRTFKSIKAFDDVDFSIHFIENSPFMRALQDQKLSTFDGLKKENVSWFDRIDQVGKENDQWTMVIAHEFFDALPVHIFQKTPRGFREVMIDINNADMSPTEKSLRFALSPGPTLASQMLISEEHQKLPVDAKLEVSPSANQIAGQISQLLNSDAGGTGLIIDYGAEHHFSHSLRGFYQHQIVDPLSRPGLTDITANVDFASLKRSMSPNVLTYGPITQRQFLLSMGIEVRTKRLNQSSSLTEDSSQRLISPFGMGDQYKFLGFEHPPSQLSSTQAPQEVYPFPT
The following text describes a protein:
Function:
Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Acts as a critical suppressor of gross chromosomal rearrangements (GCRs) during normal cell cycle progression. Involved in stabilizing, restarting or resolving transiently stalled replication forks. Prevents accumulation of DNA damage during cell cycle progression (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPPAHKRDTNVRNLSAPYNIPSQSARVAAGNAAINRRRSSPVENSPGNGFPVSEDATDYPSGTTSENESLPLNRAPRSLREVASELAQEETLPVETSDLNIDVESEVFDLEDINFQNDADDINQRFTYNNHPASVENSLTNVNSIHAQPTTISDMIDLTDETSYDPRKQKFEQGKNPSTTNAEIEKEEPSKKQVVPSSQRLADYKCVICLDSPENLSCTPCGHIFCNFCILSALGTTAATQKCPVCRRKVHPNKVICLEMMLGSQKKKS
The following text describes a protein:
Function:
Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.
Sequence:
MPYKKYMCLLCGFIYEEEKGWPEDGIAPGTRWEEVPEDWLCPECGAMKSDFEMVEVS
The following text describes a protein:
Function:
Involved in the recognition of invading microorganisms. Binds specifically to beta-1,3-glucan and lipoteichoic acid and causes aggregation of invading microorganisms. Binding to beta-1,3-glucan activates the phenoloxidase cascade.
Subcellular Localization:
Secreted.
Sequence:
MWIKSVCLFATIAGCLGQRGGPYKVPDAKLEAIYPKGLRVSVPDDGYSLFAFHGKLNEEMEGLEAGHWSRDITKAKQGRWIFRDRNAELKLGDKIYFWTYVIKDGLGYRQDNGEWTVTEFVNENGTVVDTSTAPPPVAPAVSEEDQSPGPQWRPCERSLTESLARERVCKGSLVFSEDFDGSSLADLGNWTAEVRFPGEPDYPYNLYTTDGTVGFESGSLVVRPVMTESKYHEGIIYDRLDLERCTGQLGTLECRRESSGGQIVPPVMTAKLATRRSFAFKFGRIDIKAKMPRGDWLIPELNLEPLDNIYGNQRYASGLMRVAFVRGNDVYAKKLYGGPIMSDADPFRSMLLKDKQGLANWNNDYHVYSLLWKPNGLELMVDGEVYGTIDAGDGFYQIAKNNLVSHASQWLKGTVMAPFDEKFFITLGLRVAGIHDFTDGPGKPWENKGTKAMINFWNNRFRWFPTWHDTSLKVDYVRVYAL
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.
Sequence:
MDAGGGHQAPQAALANGSGGAQQSHLNGHTQNDLSQVLEALQAIYAPNSNNDTRRQATEYLEQAKRHPDAPSQGFTLANDRSQPAALRHYGLTMLEYSIKYKWEDFTVEQGTELRGSVTELAKQTAEDDPVYLRNKVAQLWTEIAKRSWGAEWLDMDEQLVALWQHSLHHQAIVVYVLETLSEEVFNREDATAGLRGSDLGRACVEIFTPAAVLTEHLPTRDKGLDVRCGEEGWLRRLCDNLGYCLSQDYQNQEAVRTMAVKTLNALRAAMPWIIPKAIGATQVVGTLCRALAVPVVELQLAAIEVFQAIYNRHHLNDDDFGELVWPMFAPESVSLLREVYNWTIADLNINDLDDQKYTLCRKLSELANSLGLFIEQKPRQIPESSDFGGMLGFLFDIMRHPSLVVSIPVLHCWTKLLRSPVVRENDTIKSMIAGLLETSCSRLIRYESLPEDTEDVTLQFLNEDIDTVPERHAFLGNYRRFCADMIETLVRWIPVEAMEHILGQATNVLQNIYRDQPPFSPQTFTKNSPTVLRVDAQITVIDAALKGYLKWLASHGENMQEDERKRSALEDSFEQWGRQMLQARFEDPEIARKIVSLMSTLSTKALGDRPAFALTFLEYMLTIRLADDTAYPLYSDAVKDLERICSLEMQKLAIKFANDFMNVYDQLESKVNEMINDPTTDERQRMAYSAFLFIIIHRCTVLDRSTQEERMRLMLNQVKDAWQNEEFAGAVTNFQSFCGILGMGQLPDFLSVNNFRSVSDWSNQPLGGDGQALQASILERSQQLPLRLTKTLLAATTEKLRDGTPAYDSAALLWAEAIPILLPNLLQLVSHAQAFNDIDSNWSQLPVELQQVIRRVLTDRFWQAGISTESRDDFFARVSGSKSTYEGFASTVRGTVRQIRESSYFILYSLTRFRDAFYGIQDLPGPLSEALFGELDRKISGEWSEVARQVAESGDNDNLTDEMKTESILRQLTYSSVSLVAVLLDSRQEFARADTESRRDPSSPPMCDFILATPSVLEPILLFCTSTIHVRDTRSVIMIVRVLRSLLPRFKEDSPIRSYFCNDILKASITSLHEPYFVDCQKELASLIAGIIHLDDTTPRSIILSLPGMADDHRVDRKLAKLKSVNRQDERTQRAIVLDLLSSIKGVSIHEQGKMVRAGPKKRTAFQEQYMSVDQPVGIVRGTSPGLAGVSDMFGGE
The following text describes a protein:
Function:
Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in spore wall assembly (By similarity).
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MTTLSTIWLFLITITAIFQLGLSSNVTTIIDDDNNNNNNNNNNADDFLEPQIETIKVIGNKFFECESGHQFFIKGIAYQKTRQEGEIYDTTKEPHYIDPLANPFTCLRDLDYLKELGINLVRVYQIHPNANHDVCMNAFAEAGIYVLADLSEPTISIRRDYPHWDTEIFNRYQQVIDSMSNYKNLLGFFAGNEVTNCQSNIDASPFVRAAIRDCKKYINQQGYRKIPIGYASNDDANIRKNLANYFVCQLDEDEDKGQEHLNSQADFFAINVYEWCGYSTYTTSGYRDLTTMFKDYSVPVFFSEFGCNIITPRPFTEVEAIYGSTMKKVWSGGIAYEYFEEVNHYGILLTKKDGSITKLPDFDTLKMRFHAATPIGITMDEATICEPPICSNSVIDDKSSSSSSSSSFWDVALTLPPTPNEAKCECLWQSLSCVVSEDATFDEEVALRELCFKVDCEDINANGRSGKYGRYSDCNPTVRTSYALNKYYEQCGKKQEICDFQGRGELLPNRNGGLQDLENKFSSDGQNCLSLLEGKEEEKEVQEEEPDVPGLPGSNKGKEVESTPKRKGKGKSKEKEKGKLIEEEEEEEEEEEENNKTPSSGEKSPKTSKSIAGGNAITFKNDSIWKTFIEILFTCSAAILI
The following text describes a protein:
Function:
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCK
The following text describes a protein:
Function:
Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.
Subcellular Localization:
Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells.
Sequence:
MSKKGRSKGEKPETETDSVQMANEELRAKLTNIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREALIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLADAREEARRTFDGERQRLQQEILELKAARKQAEEALSNCMQADKAKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKERVILALEKELGVQAGQTQRLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMAELMGGQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLHSIQRMEEKLKSLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDETTTREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDAAWVEEKQVLMRTNQDLLEKIYRLEMEENQLKSEMQDAKDQNELLEFRVLELEVRDSICCKLSNGADILFEPKLKFV
The following text describes a protein:
Function:
Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B-lymphocytes with T-cells in immune responses.
Subcellular Localization:
Secreted.
Sequence:
MATLRVPLLVALVLLAVAIQTSDAGPYGANVEDSICCQDYIRHPLPSRLVKEFFWTSKSCRKPGVVLITVKNRDICADPRQVWVKKLLHKLS
The following text describes a protein:
Function:
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
Subcellular Localization:
Cytoplasm.
Sequence:
MLLSGSSSQSLAAALAAATGERLGDVTYDSFPDGEQLVTVPPAVDGERAVIVASTPTSDAHIEVLQLQDAARDAGASEIITVLPYMGYARQDDAFDPGQPVSARAVARAISTGTDRVLTVNPHEDGVLECFDVPAAGVDAAPQLAAPLPADLTDPVFLSPDHGATDLATSVRDAYGTGVTDHFQKVRHSGSDVTVEPSEIQTAGRDVVVTDDIVATGTTMSEAITALDDPARVFVATVHPLLAGSARLKLARAGVEAVYGTDTIECAVSEVSAAPAIADAL
The following text describes a protein:
Function:
Essential for the control of the cell cycle at the G1/S (start) transition. In association with cdk-2, regulates proliferation, quiescent state and cell fate during the development of several cell lineages. In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase. During the development of the vulva, controls the onset of vulval cell terminal differentiation by controlling the duration of G1 phase. During hypoderm development at early larval stages, controls syncytial fate of seam cell daughter cells. Involved in the progression of cell division in the intestinal lineage in larvae, and in particular in endoreplication, a specific growth pathway in the intestinal epithelium, required for feeding and gut development in growing larvae. By controlling the activity of translational repressor gld-1, regulates the pool of germline stem cells and the size of the mitotic zone by preventing entry into meiosis. In addition, repression of expression by gld-1 prevents mitosis re-entry in meiotic germline cells.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Co-localizes with cdk-2 in the sperm centrioles before the first embryonic mitosis and then to the male and female nuclei upon entry into mitosis.
Sequence:
MAGRKSSRTAERVPTTQKPERKSAILSPHDELRERLLETAIDMKENIPQRNTRNSSVGSQKSDCSETRKRRSTKEGPAAKRHSGEKHRNGSREDSLEYISEYSDDREVGSSSSQSSRTRGQPLPAMPEEEEVFDKSSSSDNLAESEESHEMVRLEERQDIEEEIEDDFDDEEEDVVNDKEEYEEIESEDEDDYPVQNEGFAVTKRLMNDEHMVTAPTFLSTAKCDGIGSPTKVWSLMVKRDEIPRATRFLLGNHPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVECSTDNFQLVGTAALFIAAKYEEIYPPKCIDFAHLTDSAFTCDNIRTMEVLIVKYIGWSLGPITSIQWLSTYLQLLGTGKKNKSDHYEEQNMYVPELLRSEYLEMCKILDFLLFEIDSFTFSYRTIAAAVLFVNYEPTCAVEKATGFMQAQLEKVIEYVEPVCRAFAKQRQLLDDVIPKHESIKSDDSHNIQVYVKRSSMEPIVKSERERIQHLKARRLHPQRLF
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MAAVMMEDPSLGQPAEAESASLHLQDMEMAYKMQLHEVLLASSHTATQNGIPAGIDDYTREILDVEVETQEQQEALRRQTEEVERAREATAGERAAAAARQEAAMQYRLEKSDANFARYLDELSDSEWEDYGDMYDIHSLPPEERDFPEQVQLRCLGIAENDRAGAGALLIGSNDQPLMELSPQLEGVHTACTAELQVILEGLRAVRALGFQRPRLALSPFVLLKLSGSVAPIDATELSTLVAVQGLIAELGANVKGVPIERNKRALRLARTSIAKYVNEPPPVLSHPVLPDEAKGVQEPCPICLENHPPAAMFALARCRHKFCKACAAQHATVRVRARALPVPCPDPGCGGEFSREDCEVVLPPDVFGLLLDVQAENCIPGEERVYCPYKDCSVMMSAGDWGGADAPSSSSHPHRTAVGRVDCVNCRRPFCLECRVPWHQRMTCRQYQDLPPDQRAIEDVKLHNLAAEKQWKQCPACRRMIELAEGCNHMTCVCGTEFCYVCAMLWRGGRATCECPLFDDVAEENEEQVRHDYEADRRRRLVRAYKTRLCVHYMRGHCRNGDWCRFAHGENELRYPEDNMED
The following text describes a protein:
Function:
Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization.
Miscellaneous:
MISCELLANEOUS: Present with 2133 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MNDRLSLTSLFPRCLTTCLYIWTAYITLTRIHQIPRWFLALTIVPTLAVALYTYYKVIARGPGSPLDFPDLLVHDLKAAENGLELPPEYMSKRCLTLKHDGRFRVCQVCHVWKPDRCHHCSSCDVCILKMDHHCPWFAECTGFRNQKFFIQFLMYTTLYAFLVLIYTCYELGTWFNSGSFNRELIDFHLLGVALLAVAVFISVLAFTCFSIYQVCKNQTTIEVHGMRRYRRDLEILNDSYGTNEHLENIFDLGSSMANWQDIMGTSWLEWILPIETFKYKKSKHTKDEKGLYFNVRPQVQDRLLSSRCLEDQLLRRVTPRPSLEADRASVEIIDAN
The following text describes a protein:
Function:
Negative regulator of T-cell proliferation.
Subcellular Localization:
Membrane.
Sequence:
MMKPEFSYFSGLCVYFLFLQVTISSEKWMVTTPTRHVLARVGGQAELSCQVIPPQSVGYMEVRWFRSGHSQPVYLYRGGHSMSGEAAPEYANRTQFVKEAIGEGKVTLRIHNISILDDGPYRCSFNDSGFIDVASMNLNVTAVGLETEIHVQAPDADGVIVECNSGGWFPKPQMEWRDSNGETLRHSMKSYSQDEARFFHMKMALLTNRLQGNIICCIFNPVTGEEKQTNIILANELFYEDHIWMKILVIIACIILFIISFLLLISCFCRRQGCASGYVSKCFCVFNSWPVQILNFLFCTGLLFGIYLPHRSRVSLSDPQFPLYNKWIKDLLFVILFLTVFFVLPIIALILRRLSPTCLNKQKNKDVIMDSKPGLGKAHKVSTLYRKHPRKSWEQER
The following text describes a protein:
Function:
Reductase active only on small flexible lipophilic carbonyls. No activity with cyclic monoterpenes, tropinone, nitrogen-containing tropinone analogs, tropine or pseudotropine as substrate.
Sequence:
MDKRWSLQGLTALVTGGASGIGHAIVEELAGFGAKIHVCDISKTLLNQSLSEWEKKGFQVSGSVCDASNRLERETLMQTVTTIFDGKLNILVNNVGTIRTKPTIEYEAEDFSFLISTNLESAYHLSQLSHPLLKASGNGIITFISSAAGIVSFDAASIYGLTKGALNQLARNLACEWAKDGIRANAVAPNFITTALAKPFLEDAGFNEILSSRTPLGRAGEPREVASLVAFLCLPAASYITGQTICVDGGLTVNGFSYQP
The following text describes a protein:
Function:
Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Sequence:
MIKRALAPIVQPQRLFAALMVIGGGGRSATTTTTTTTKACGNGSSQSPPSTPLLSSKSSTITSNKKSAIPSSHLYIPKKSTLDSRQIGNYSREYSTSSSSSSKKSIFNDTYLNDLFWQLSSQGPAFEVNPNNIDFIQEPIDFYNHLIDGVKRSKKRITMASLYLGTSKQEIELVKEMKLAMERNKELKIHILLDGLRGTRIGLDKESSATILGELLSLYSDRVTISMYHTPDLNGILKKVLPPRINETIGVQHIKTYIFDDDLLLSGANLSKDYFTNRQDRYVLIRSTSTVSNYFNEIVEIIGSLSLHVDKDNRNQLLLSSGSIDPVTQSNEFKNLAYTKLSTLLKSHSYYPSNSNSNSSVDSPFDCNNINNGETTWIFPTIQMGPFNIRQDEVVTSHIFESVPNDSKFFITSPYFNLTENYLNLILTGKPKLDIITCSPQANGFYGSKGLSSAVPDCYAIIEKRFLQRVQDTDNGDRISVQEYIRDKWTYHAKGLWIQVKNQQHPSITLIGSPNFGSRSVEKDLEAQIILITQNKQLQQKMENEKNYLWTDTQNANLELFEKRKVSLMVRFLVYIFGNYL
The following text describes a protein:
Function:
Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MPRAPHSMPLLLLLLLSLPQAQTAFPQDPIPLLTSDLQGTSPSSWFRGLEDDAVAAELGLDFQRFLTLNRTLLVAARDHVFSFDLQAQEEGEGLVPNKFLTWRSQDMENCAVRGKLTDECYNYIRVLVPWDSQTLLACGTNSFSPVCRSYGITSLQQEGEELSGQARCPFDATQSTVAISAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVYALEHGDHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSLTGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCAGVGAAALFSSSQDLPDDVLLFIKAHPLLDPAVPPATHQPLLTLTSRALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLPPGGQSLGPEPIILEEIDAYSHARCSGKRSPRAARRIIGLELDTEGHRLFVAFPGCIVYLSLSRCARHGACQRSCLASLDPYCGWHRFRGCVNIRGPGGTDVDLTGNQESMEHGDCQDGATGSQSGPGDSAYVLLGPGPSPETPSSPSDAHPGPQSSTLGAHTQGVRRDLSPASASRSIPIPLLLACVAAAFALGASVSGLLVSCACRRANRRRSKDIETPGLPRPLSLRSLARLHGGGPEPPPPPKDGDAAQTPQLYTTFLPPPEGGSPPELACLPTPETTPELPVKHLRASGGPWEWNQNGNNASEGPGRPRGCSAAGGPAPRVLVRPPPPGCPGQEVEVTTLEELLRYLHGPQPPRKGSEPLASAPFTSRPPASEPGAALFVDSSPMPRDCVPPLRLDVPPDGKRAAPSGRPALSAPAPRLGVSGSRRLPFPTHRAPPGLLTRVPSGGPSRYSGGPGRHLLYLGRPDGHRGRSLKRVDVKSPLSPKPPLATPPQPAPHGSHFNF
The following text describes a protein:
Function:
Stimulates transcription from the HSP70 promoter.
Subcellular Localization:
Nucleus.
Sequence:
MKTKKKIKAQKTKSPVDRNDDEELSGLVSGIHDDGGEIETAGLGDGEDIPASEISDVIKKLKLDRFKDIAKKPKEKPVQKQDKTAGQTAGQKNKKQLQDKTQKKDKIQRDDKPKEDKPQKKDNSTPGTPATSKKNQKKKNNEKQKDGGNQNKDKNPPSGAAKTPIKERTEKPAQVEKQIKNEKIKGALSLEVPKTSSILLPTGTKWHSIQDGVKATGSPAVSSEGVVSSYMEYATKLYDQEVELHAAKKSSDSGSQSRWMQTVAKSGALSDKVAALTLEVQGAPIHTPLSLDALLAMVKKKGRREALIGLDAAKRLFLEELLPSNRRLTTFAQHSFEDLEKRCSKNRLSRDKQVLLWFFEDQLKQKYGSLLDMIEKMLQDTVSAIKAKALSCCYELIVNRPEEEKRLLRLIVNKVGDPDYKVAAKAVHWLQKLVDVHSMMKIVVVQAIEELLFRPNINTKAQYYAVCFLNQLVLHPEEDQLATQLIIVYLSFFKACTKQKKIDNKMLSAVITGVHRAFPYSKEDEKVHEQLDTLLKVVHQTTFNTSIQALLLIKQVLDKRQSTMDRFYSALYRKLLDPHLSSSPRHAMFLNLLYQTLKSDDVINRVKAFVKRLLQVCSWQQSPFIAAVLVLVSELIKAKPSLGKVNSWNDDDDEDENFMDVQEEEDDDEDKEGEADAKGKTTSHPEKPKPSSKDKASWVHRPVRPGGKEGVPSGYDPLARNPLHSHVDNAVMWELKVLSNHFHPSVSLFASQLLAGSLVFYTGNPLQDFTPGRFLDRFVYKNPKQKQIGKESVMQPKSRSYKPPAIRSMPVNSKNFTSMTEESVPIDEMFFHRFFSQKDLKDKKSKDSKKDKKADSQDNEDGKSDDEDEEEDFDEKITSNANMEAPDEIDSDASSVDDDEFDRILDEIEGGQEDEEDDIDFAREFQKKPSKKSKKRKAEEDDSSSDDDDEDDDEEDDVGMESDDDEEEEIGESADVDGLDEEAFDMSDEEEELSPVKTSKRKQKQDKKSAKKQRKNTQELGDVTEQISSMIDENVGSKFDVGLNALANKDKADMKQLRWEMDRDRWVRGVDARTKVRAKKLQKGPKAKGFRGRGKKR
The following text describes a protein:
Function:
Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The A20-type zinc finger domain mediates regulation of NF-kappa-B activity; The AN1-type zinc finger domain mediates association with TRAF2.
Sequence:
MAQETNHSQVPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSSNGRISPPATSVSSLSESLPVQCTDGSVPEAQSTLDSTSSSMQPSPVSNQSLLSESVASSQLDSTSVDKAVPETEDLQASVSDTAQQPSEEQSKSLEKPKQKKNRCFMCRKKVGLTGFECRCGNVYCGVHRYSDVHNCSYNYKADAAEKIRKENPVVVGEKIQKI