lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Plays an essential role in the development of the embryonic brain and central nervous system (CNS). Has a role in osteoblast function, bone development and bone homeostasis (By similarity).
Miscellaneous:
MISCELLANEOUS: Many mouse mammary tumors induced by mouse mammary tumor virus (MMTV) contain a provirus integrated into a host cell region which has been named INT-1 (now Wnt1).
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Secreted.
Sequence:
MGLWALLPSWVSTTLLLALTALPAALAANSSGRWWGIVNIASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
The following text describes a protein:
Function:
Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.
Subcellular Localization:
Cell projection, filopodium. Cytoplasm, cell cortex. Membrane; Single-pass type I membrane protein.
Sequence:
MKVLLLFLLCGVACSSADPSRHDNDANLFTIRHEQHKKCLEYDNNQITMASCSAENEALLWKWVSNHRLFHLQSQMCLGINLTIPLDPLKMVPCNSDLMLWWRCHDGSIYGASQYKLTEKNGAVTASFSSNDEWRRDNTLENVCYHLYREIYTNRGNSAGKPCEFPFLRHGTWHHDCIKEANDTQEWCATTSNYDTDGKWGYCLKPGNGCQESWVQNVKLQSCYQFNMESILTWKEAYISCQNQGADLLSISTPEELQVFTDKEDVPDSVWIGLNHLDTSGGWQWSDHTPLRFINWDKDRASFSLLDDKDCAILNTDTGRMENIHCEKSLPYICKKNLRNTESKGDWFYSETQCEPGWIPYNGFCYMLHQPSRWNNAEPSCKKEGADLISMHSLADIEMVVTTFQGESEDIWSGLKNEASPAFFEWSDGTETDFTYWDRNEPTGTFNSITHCVSFAAKSGRWHVKSCKEEFKYICKKKGEINDTITDKGCQNDTNSVRHGNSCYWVDPTEVPFGAKCNLTVTNKFEQEFLNYLMKNQKKLNGKYFWTSLRDSNHTGDYCWETADGKQDMTYSNWNVLEPASRGGCVAMGTGPPLGKWEVKDCKTFKAQSICKRQIGSPKPDTRPKPTDTCPEGWYSGSDLFCYKLFHVERILRKRTWEEAEGLCEEFGGHLASFTHEKEKETLTAFILSATRRNPWIWIGLNKRNPALHGSWQWSDDRPVSDVVLPSDFNEDDHDLKDCVAFMPYRDSWENRIVNTMRVMHCDVTLEWVCQVPKGTPLKIPEWYIPDWKDSSHPTIVTAQAHFWFITDPLLDYKEAQLYCSNAGSTLASAQFLHELENIQEQLKHLAEVKKIFPLTQNWWLSSLQVEEYSWRLRFIFGTHGGKDCLFVSAQSWIKGYIEGIDCYQKLPFICESRNMTLLERNTTRRDVFKGDCPKTWLSFGDKCFIKTKPKLMTYHNAEEECKAFGATLPTITSQREQDFITSLLPNMTTAFWIGLRFFLYESESKWIDDQEVNYTNFNPLLHSLDPSSEFQLRERNEVSYIHCTFVLNDPRSTFPGTWDTTYCGSYQYLSLCQQYKASPGKPTPMVVPEDVEYQGQKYKMIQKNVTWYEALAQCSRHDMKLASLTDQYHVAFLALKVGALGHGMWIGLSSNQDGIHYRWQDGKPVTVSRWSKDEEENEKCVYMDTDGFWKTRNCNNQIPGAFCYTVPEDSVAKPVENHTVSCPQRIKDTQWIPFRNSCYSFISTHKRWPLNDTHSRFVCRDLHPDAVVLNIRDEEENNFVMNELQPYRDLVTWLWLGMYYDIKDKRLLWFDETFVKYSNWRYGRPYVSNEMFYAGMSLEGLWDTHSFSDNEEVMSFKYKTIVACKIEMGSKEQYSQSQPADMVHEGLTYHIIQKRLTWNEAAEECNKDGSLLASVHSEAQQIFLESIVKQDGFSLWIGLSSYGANHTDFKWADNSQYDYEHIHFAQIIYAKNCILLDTKGLWHSNNCTDQLEGAICYKASVASLKVRVAIGVTAFLIILFLLLGLFLFHYKEQISGFSPTIHYRHMGDDTEPCLPFPTGHTRSLPARPRDSQDTFALYPLGTSPGITEEKPGEEKPMRALILLSLCSAAYCAAGLPGSAPQENGTGCPSPAWVWFNSSCYTLLHTTPKDLLNIEPAEELCKAYGANLISINTEEENTFILKMFQAEWKGPEKILLGMFYDSDDDTMKWFDQSEVSFTNWRGGEEKNHNNLITCATMSTITGLWHLDSCENVAEMATLCKKPTNPQSEYNLSDQGALTITLIIFIVFLVISVSALLLVLYRRGSPGFPSRNYTLASNVLPYTDQDVLMDTEETEDSNA
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.
Subcellular Localization:
Cytoplasm. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Nucleus, nuclear pore complex. Note=Localizes to the nuclear envelope and spindle pole body.
Sequence:
MESSDEVDLPVYHLQNAPIENGKLNDWRSKGRTVAFKLHPFLRKGLAYINNKEFDENTLKSDKFEEVESLVYEFSTPSTLIEPNYLLTAWHELWEELQDTYMTPILDSEANLLLLTQFYGKISSLFRSKIIQVLEELQSRINEGEKDCQPVLDSLWEVESAWRCAEAIYFPPSSPYTLSTGILDWVNAYDPQPIADDGLEIMAYRIPYQHPEFWPYVNKTAIRGLFEQTISCLEMSGLTKEWPVLKETVDELIDILRYSPCTHQKRIRSVSDFERRWKLWRSRLANLRHVVKKHRDIDSEVLDDFVVLLDILNGNKEVIMLSCAHWQEYFSALAFLYGPLDCKNPEDISLLYQLATGEDSKFYVNGTIEYEQICVNLCSNEPLNAIKHAYLLDLGLAVHLADLLSKSGHLRDYITEEYPITLREHLILEYGQCVLESRNLWQTSFAYWKCVADSGYQRIKACIPYVPLSDVDAKETALQLCKQLKLRDEAQLVLTHWADELIARNHYGEALIALDNAANYSALNRVTWELFDICIAEKKSFSPDKDELLYELFSSPKACTPTLASIISPAATIHQYFFYLQHKKELNASELLVGLLTMVDFPSSRFPKLLELLHEFLNNPLQSNSTDFKLSLVNVYDCIAVLQDQQSTVKDQQLLLSIHERLSSAISWYFLHLKK
The following text describes a protein:
Function:
Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
Subcellular Localization:
Nucleus. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.
Sequence:
AAGRGAWVRTWAPLAMAAKVDLSTSTDWKEAKSFLKGLSDKQREEHYFCKDFIKLKKIPMWKETAKGLAGKVENPKYKKDKQLNEKISLFRGDITKLEVDAIVNAANNSLLGGGGVDGCIHRAAGSLLTDECRTLQNCETGKAKITCGYRLPAKHVIHTVGPIAVGQPTASQAAELRSCYLSSLDLLLEHRLRSVAFPCISTGVFGYPNEEAAEVVLATLREWLEQHKDKVDRLIICVFLEKDEGIYQERLPHYFPVA
The following text describes a protein:
Function:
This protein binds cations of several transition elements. Thought to be involved in metal ion homeostasis.
Domain:
All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.
Sequence:
MVCKGCGTNCQCSAQKCGDNCACNKDCQCVCKNGPKDQCCSNK
The following text describes a protein:
Function:
Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, transcription or reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.
Sequence:
MSKVSFKIMLTSDTQLPYKVLSVLSPAATSAVITNDGIGINLAQTAGNVFLKQGSELWIIPRDHVGSC
The following text describes a protein:
Function:
Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.
Sequence:
MALLQLYSSGLIFTPQKALNRGNFVRNPPGWLSKGPKVEENWSPELQTLGGLSHWVWSVAFSQDGQLLASGSDDKTIKLWDPTTGALKHTLVGHSDSILSVAFSQDGQFLASGSDDETIKLWDPTTGNLKHTLEGHSDWVRSVAFWKDSQLLASGSDDKTIKLWDPTTGALKHTLEGHSDSILSVAFSQDGQFLASGSHDKTIKLWDPTTGNLKHTLEGHSDWVRSVAFWKDSQLLASGSDDKTTRLWDPTTGALKHTLEGHSDSIRSVAFSQDGQLLASGSDDETVKLWDPTTSFLMQTLEGHSDSVWTVAFSQDGQLLASGSRDRTIKLWDPAIGAVKHTLEGHSDWVRSVAFSQNSRFLASGSYDKTIKLWDPTTGNLKHTLEGHSDWVQSFWDLTTGAFNVLWVLAVLTPTLNFPSICRSRLPTWDIILGQSELWLPPDYQSSSSTAGWTHKWQSHCNKPLTVYFILRGLYSNSLIFSNLVSRPGLGSTELYKAHQYSWYCKSHTKSSGFIPVIFHVRSFDRSLRPKTGLLSIHKECLTLGFEDCVRYG
The following text describes a protein:
Function:
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGKEFCWMEEPSPHGQDSASRGHFFKDPGMPSETPQAEERAAGCPRLSAAHLRKGSLEKRPPGDKDTKEHLWISPDTPSRCLWQLGRPVTDSPHHHTTLAKSPQILPDILKKIGDTPMVRINKIGRRFGLKCELLAKCEFFNAGGSVKDRISLRMVEDAERAGTLKPGDTIIEPTSGNTGIGLALAAAVKGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLRNEIPNSHILDQYRNASNPLAHYDITAEEILLQCNGKLDMLVASAGTGGTITGIARKLKEKCPGCKIIGVDPEGSVLAEPEELNQTEQTAYEVEGIGYDFIPTVLDRSVVDKWFKSNDEEAFAFARMLIAQEGLLCGGSAGSAMSVAVKAAQELQEGQRCVVILPDSVRNYMSKFLSDKWMLQKGFMKEEDLSVKKPWWWHLRVQELSLSAPLTVLPTVTCEHTIEILREKGFDQAPVVDESGVVLGMVTLGNMLSSLLAGKIQPSDQVRKVIYKQFKQIRLTDPLGKLSHILEMDHFALVVHEQIQSWDLALSGVGGGPADHSHGESSKRQMVFGVVTAIDLLNFVAARERIQKR
The following text describes a protein:
Function:
May function in a transcriptional corepressor complex.
Sequence:
MRTGGYTIQQTLTTEAASVLKHSLTLARRRGHAQVTPLHVAATLLSSRTSLLRRACIKSHPGFSTNYQFAPSRLQHHHHHNQNHPLQCRALELCFNVALNRLPTVPGPMFHGQPSLANALVAALKRAQAHQRRGCIEQQQQTQTHPQTQQTQLLAVKVELEQLVISILDDPSVSRVMREAGFNSTAVKSCVEDCSVSSVFYGGSAVGVFSSPNSPDQQQQHHNSINRLHHYQNPKDFNFINPNFPLWQTHFLNQSPDQNPLLLSSSASHHHQQQRLREIDLKLVVDVLMRKKTKKKNPVIVGDSISFTEGFVSELMAKLERGEIDQTGELKQTHFVKFHFSPMASKFMRREDVELNIKELRKKVLSLTTSGKNAIIFTGDLKWTVKEITNNNSGGINEISSSYSPLDHLVEEIGKLITECNDDGDDDDCKTRKVWVMGTASFQTYMRCQMRQPSLETLWALHPVSVPSSANLGLSLHATSGHEARNMSTVNATKSLSGYDKAEEEETISHVLSCCPECVTSFDREAKSLKANQDKLLPSWLQSHDADSSSQKDELMGLKRKWNRFCETLHNQTGQLSMMGNYPYGLPYGSSHESSKSTSLIDSLGLKPNQRATNSIAKFRRQNSCTIEFDLGGNEHEKGESINEAEDDKGNETVTLDLGRSLFRSDSVTDTRLKLSALVKALEESIPRQTVTMRLIAESLMDCVSKKKDSWIIIEGRDTTAKRRVARTVSESVFGSFESLVHIDLKKKGNESKASPATLLAYELKNPEKVVFLIEDIDLADSRFLKLLADRFEDKRRIKTGIDHRQAIFILTKEDSRNVRNRDSVLQIGLEITAQSPGKKRKPESDLSIENGFWMKKEVCSRQSSFNSSYLDLNIKAEDEEVEGEISPISSDLTGEEETEFSSSSNFLNRIQNRFVLNRSCEPGIEKGMITAAFREIFPEREEGGGVRFSVEDKLVEELYGIQNGAFERWLKEVFQTGLLTVKKGGKKDTGVIRMVFGGIVDNKGYGGGVGGYMATFLPNKVQVSKFE
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MGEEISNTVNLDLNLGPGPEVTNASAWANGPLNGESEPLRRFWSSLRQVDVRHVPPGETHSPLIELSQLIIPSALPAGEEESKKCENGNKVIEEDSVKEEKRVVEKSVGSEGSFFDCYVCLDLSKEPVVTNCGHLFCWSCLYRWLQVSEAKECPVCKGEVSVKTLTPIYGRGEKNKRVSKEGVSDKNKKIPSRPQARRVESLRTTLERSGYVGTERIRHLQDGQQLQTEPRTGETPARQFLSRVMTSRGVRAEQNQSSASLVAAPLDDFRQMGAAIIQRQMMQAARLMVPFSPVLTAAERLEDAYLMRHTFDEQLNVPSVGGEDRDSFSSIIGVMNSESQVDTAAEIDSMVTVSTSSSVRRPHENNGSRVSDVDSADSRPLRRRRLA
The following text describes a protein:
Function:
Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule (By similarity). Plays a role in cilia formation. Required for photoreceptor development.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, cilium. Cell projection, dendritic spine.
Sequence:
MSKSKSSESVKVVVRCRPMNEKERVANFNRVVSVDVKLGQVAVCNPRGASSHEHPKVFTFDSVYDWNSKQMELYDETFRPLVDSVLFGFNGTIFAYGQTGTGKTYTMEGVRNDPERRGVIPNSFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQARRLELKERPDTGVYVKDLSSFVTKSVREIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSELGPDGENHIRVGKLNLVDLAGSERQTKTGAQGERLKEATKINLSLSALGNVISALVDGRSTHIPYRDSKLTRLLQDSLGGNARTVMVANIGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKEQLEKRSGRKRRRRRRRRVGEGGEEFEDGEDEEDDDDDDEDEEEGVDADKNIADYWHEQQEKLEKERRAIMEDHSLVAEEKQRLLKEKERKMTDLHKEKEASEMLTAKVKAMESKLLVGGKNIVDHTNEQQKVLELKRQEIAEQKRREREMKQEMECRDEETLELKETYSSLQQEVDIKTKKLKKLFSKLQSVKSEIQDAQDEHVKYRQELEQTQNELTRELKLKHLIIENFIPMEEKNKIVTRATFDEEDDLWKMTPITRIQNSDHQMMKRPVSAVGYRRPLSQHARMAMLMRPDVRYKAENILLLELDLPSRTTKDYEGPVIAPKVAAALEDALREEDEIQVDASGFHASLGSSPGLSASAAGFSKKPKSGRPKTGKKVSTPTSAHSPLSGSGSPLYPQSRGLVPK
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MGRDETETYITVPSFFKCPISLDVMRSPVSLCTGVTYDRASIQRWLDGGNNTCPATMQLLKTKDFVPNLTLQRLINIWSDSIGRRHNGDSPVLNPPSGREVPTKEEVNVLLERLMSLENLMKIVRFVKDSDSNREFLSKKMEFVPMLVDIIRTKKTKIELVIMAIRILDSIKVDRERLSNLMLANDGGDCLTAILLAIQRGNLESKIESVRVLDWISFDAKSKLMIAERDGVLTEMMKSISITESSDPSLIEASLSFLITISKSKRVRSKLIAAKAITKIKDILLTETLTNVAVTEKSLKLLETLSSKREGRLEICGDDNGRCVEGVVKKLLKVSTTATEHAVTILWCLCYVFREDKTVEETVERSNGVTKLLVVIQSNCSAMVRQMAKDLIKVLKFNSSALAAYETKTTHIMPF
The following text describes a protein:
Function:
Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins.
Sequence:
MPNLYVQSYSEESYKQQFLQTRMRTRRLYLALCLTLVLLFINVAAYQTILGNNSKRTKLFATNDQTRNKSRRRRQDADVPDISNSPTIFESDRLPVTGNSTIGYTLNTRLMASIGNGHLATTVYSDTIFVNGLYSGDGFKGRSHRATIPSQNNIRAMLPSEEGAVRRFALDVERGVFFETMTTDQVTVEQRTYAHQFYTRLLVTEIHVTRGQGTGDIVIGLTTNPGSDGQDFLWDSISSPSVASRYRHGTINVTETATSTRSEVHMYWTPVPSSITLASSESQKSVSYIASIDTDQATARESFEIGRQFARSDLYPTHLAAWRKVWDAGRIEVEGNLNLQKIINGALYYILSSLPAQEHYGTANQFYGLSPGGLANGKLLQDYQGHSFWDTETWMYPPILMLHPTLAKDILSYRIHVRGPAYDRAQQNGHQGLRFPWESAFTGVEVTPGDICWECRENQQHITGDIAFAARQYVSATRDLGWLQDENGWELIRETARFWKSRPTFNRKRGLYDINGVMPPDEFHHTVNNSIYTNVVAKLSMDFANYTACLVGEAEETAGEVESWVTDVGDRLYLPEITDEKYHPEFEGYPKGELIKQADVILLGYPLMWKMSDEVRKNDLNVYEEVTDPTGPAMTWSMFCIGWLELQEYSKASQMFQDSYSIYVKEPFKIWTEAHQGLGAVNFITGMGGFLQAVLFGYGGFRLHVDHLDLNPVLPPDTDSMKIYGLDYLGSSLDFTISRDQVTINVTSLGGDYPLEIKAGDTSYTLQEGVPVQLPRGPASIATTRQDSNRCTPPVVGDGTADRLKATLWMLLLSVLLIAMQ
The following text describes a protein:
Function:
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
Subcellular Localization:
Peroxisome.
Sequence:
MTQQPPDVEEDDCLSEYHHLFCPDLLQDKVAFITGGGSGIGFRIAEIFMRHGCHTVIVSRSLPRVSEAAKKLVAATGKRCLPLSMDVRVPPAVMAAVDQALKEFGKIDILINCAAGNFLCPASALSFNAFKTVVDIDTLGTFNVSRVLYEKFFRVGILLVVVVVVRFPPVGYLLIALPYMFQDHGGVIVNITATLSMRGQVLQLHAGAAKAAVDAMTRHLAVEWGPQNIRVNSLAPGAISGTEGLRRLGGPKASSKFKYLSSPIPRLGTKTEIAHSVLYLASPLASYVSGIVLVVDGGSWMTLPNDIGRLLEFESSSAKL
The following text describes a protein:
Function:
Catalyzes the hydroxylation of L-4'-hydroxyisoleucine (4'-HIL) at the C-4 position to form L-4,4'-dihydroxyisoleucine (4,4'-DIHIL). Together with HilA, catalyzes the two step conversion of L-isoleucine into L-4,4'-dihydroxyisoleucine. In vitro, in the absence of HilA, can also catalyze the oxidation of L-methionine and the C-4-hydroxylation of L-leucine and L-isoleucine.
Sequence:
MMEYATHLSRQGYAFIPGDYYRSTEAMQFSNKEDFLDELEELKKGYENLLLDPYSPGNRWRGYAQCKKNEKGELTFGKFNPYKQTKAFNPDTGDIIRDYPLLPEAITRNRLFQTLLHDDLSLVDAYESIGPVDSLTIGIHFFRYQATENEPAYSSPVWLHKDDEDVVFVHMINASPNMLGGDSLIASHPRSIDRVLRLEQLFDTLVVNHDKLHAVTPVGARENSGPAQRDIILITFQKNEEKTACPV
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 (By similarity).
Sequence:
MDVVPCLKVPQRHAQMYRKYLESQGVLDRRYGAEKHSDGTVTLLVVASALPQLDLVALKEHVAHDSFCEIVDIQAQLSKKSKVKSVHMKLVEAARSFLLSKGKEWSEDLGRDIPGRWQCHGDLVLFTEGCFSNAVWKEIGSEFWTAVALTLGVKRIAQIKKISQDGYRTPIVTMLLGDSSHVTHIDNHIRYEFDVTKCMFSSGNITEKLRIASFDCSGETVVDLYAGIGYFTLPYLVHANAAHVHACEWNPDAVAALQRNLEINGVSNRCTVHQGDNRQLSLSDLADRVNLGLIPSSEEGWPVACRLLKRSTGGIMHIHQNVTAPFHHEPSELNSSVEGSSVEVSPLRIQKDMQVWTAWASETAKRICTLLLGITGSEWKTNIRHIEHVKTYAPHISHVVLDLECKPL
The following text describes a protein:
Function:
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPGVPAECNEELDEGELELEELEGEEAGIVPEEEAQLPERAKRRRWVQCSDLVFTFSHLALASVIGVLIRCGLEDLFGSRVLGIVGDQTALFTDLPVNMVGSFFMGVIAFAWKDSILRRSNALFLSLTAGMLGSLTTYSGFNQSITTLFVEGNWAAALLGLLIGVELPVVSLVVGIDFGRGASWAFSRLLQPRPSISLSRITADEQSPTEPKTASQKSFRQLPAGASNAGTRPENRVVAPEIRTTPSKLCERPPKTEPLNPQRVSDKTRLRRAAAAAALWLGVVLPLAAVGAKFDTGSSRRREIWLAAALAPPGVWLRYLLSRFNVRPKGGLKWLPVGTLLANVIASAGMAGLSVVLVSVRGLATRLWCQGVEIGVMGALSTVSTFAAEIYLLDQGKQHVWRSYVYILVSLLASQTVALLIYGVPVWIMHYD
The following text describes a protein:
Function:
Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.
Sequence:
MRLLEVILHSSSGMKSKPPQADAPRRVEPHSFEVSVKQLNDLLTDDSGFYSWPTKHFHEVYPRIYIGNAFVATNVLRLKRIGITHILNAAEGNSFMHVNTSSQFYAGTGIVYHGVPASDTDHFDISVYFQEAAEFIETALRSKNGKGRVYVHCREGYSRSPTLVIAYLMLYKKMDVYSALATVRQKREIGPNDGFLRRLCQLNQRLVAEGKLWNE
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAGGHKKNEATRQTDEVIQQKYDESLSKHKNRCELSLTFEYKLSNKLRARLKAAFFKVDHGWEDQTLDQVETLVRKENHVHRRSRSINDLDSSKLRRPHHPNSIMGSNTGKLRASSFTRLVSPREGFAQLPYKKPVSPYSSSSAVSSTSSSFDRTSPPWLNYVEPHTELPRLPFELSHASTASAKSPLFGMNYHISRPEETDESLRLGTANLSRIRKSTSLPFPTAYPLSADDCKAAEVMLTLVNSMPSKKP
The following text describes a protein:
Function:
May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.
Subcellular Localization:
Nucleus.
Sequence:
MSNAPETGALRRKSSLHIRDTRIAGLYDLEKTIGQGHFAVVKLAKHVFTGEMVAVKIIDKTKMDEASTSQIMKEVRCMKLVQHANIVRLYEVLDTQTKIFLILELGDYDLHDFIIKHEKGVCESLAQQYFCQIMTAIDYCHQLHVVHRDLKPENVVFFEKLGMVKLTDFGFSNSYEPGEQLNTSCGSLAYSAPEILLGDSYDAPAVDVWSLGVILYMLVCGRLPFQEANDSETLTKILDCKYSIPDVLSDECRNLIQSMLVREPQKRASLEKIVSTSWVQAGDRGLSTAIPLIVRHHLPTSAHATIIEQMVAGAIASEEDILRFLENDEYNSVTATYYLLAERVLASYREEQARELLAKHVEWDDRPDPISDNSGATTRSNINSRCRSRSNSWRARPCSILKEESEEELSSYLRSASRQSSRFYPLHDFVSSPRSASRCCSAQLSRQNSEEAMSLKSLDSDSMRPTTFYIPNSAVSTTNPTTPTSAIINRFDEVLSPIDEREGSESDLVRKNLRKIVLNEIVDDSLAGSDEHAIRKSSDSCLHAHHQLLRSASAKRLLRRNSSPSVSMFSGITRDRVSPQAVQELLDLNRLGGVRGRAASPESVRSSRSPSPPASSSGRTSPAMSTISSMSRLKVSASNVTNSGMRKLSSSPHLLGICEETEDGSEVLQSTSSRHLRTLDDRGGRANRYRSASTGLVHLPSRHHSVHATKSSAASLLTTPFVSKPQGITPTPSSSSSTSFVQFTPNTYSAVRSIRPRQAIVSPDILRRYDPHQRFIVRSKRSTSCSSSDASDDDDGRRLTMLSSKCASKFDEKNKKDDDDEANGGTTGKRGNSGSGTTSLTVTGKQSNNQSGIAPQSNEKRSTLNDSVLPLRPIPEMTLLDQTLTSPDCASIRDRILHTSLSTQTMIRKWTEMDSWYGTPPRDYEDRTHLHEKTPWLRCLRRTASSQDLLRESDEKATSEHGNDSGCSTTEKDGEHQCTSPQFIQQNMYNDSKFSFLNTLPMEKVDRWLQCADFVF
The following text describes a protein:
Function:
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
Subcellular Localization:
Cytoplasm.
Domain:
The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
Sequence:
MSLELPNVKSNPSGWGPITKLEKFTDIPYAPFSKGDKIGKCSDWNSNVRNYQRQNYGSNVFNPFTFKLEDDEDSFKLVDYTRVSAKLKNKGKTYQKQFYQQSKRGGSSNRGAARGRGGRYANKYWNDRRQRNRESSIEIGSSWESKEEFDLQTFKQYTLENLPESETIGTYGKVKYYNRVYDRINTKNEKKLQKSEVNVPLIPTSDDKVIRSEYMNGNVYATDSILAILMSAQKSVFSWDIVVQKVGARLFFELRPGTSEQLTVNENVSSHQDEKDPINTSASLSSEATQINLNYWQQVLSSDAEPVALDNELPEGEEFENTVDVGYAYKKWDLGDDIVVLARTEIDAAIEDASGEPKFISIKAINEHDSNRFGIEFRKKLDTQRAAILATEIKNNSTKFAKWSIQSTLAGCEMMNLGFVSRDSVRDNNNHVILGTQFYPVADLNKQNGVDMKNCWGIIKHIAQTCMKLANGKYLLHRDPNRNVITLYSVPENAFDQIEEETEEEEEEEQSKGWVDESRE
The following text describes a protein:
Function:
Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing (By similarity).
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MPTMPLLLAALAALAVLALAARPSPSCSPGPDPSGKCQRLVYTHSATCVDLHLRTCADAAYNHTSFPTPLEHRSWEAVESSPEYMLLGVIHFLLEGQCNPDLRLLGCSVLAPRCEGGHTQRPCRHVCEGLREACQPAFDAIDMAWPYFLDCAQYFAPEEEGCYDPLEELRGELDVEEALPSGLPPTFIRFAHHSYAQMVRVLKRTAARCSQVAKTYSIGRSFEGKDLVVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREVLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASTRGVRTDHIPISQYYWWGKVAPETKAIMKWIQTIPFVLSASLHGGDLVVSYPFDFSKNPHEKKMFSPTPDEKMFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYGLWQQNKEPLLNFLEMVHRGIKGMVTDKYGKPVKNARILVKGIRHDVTTAPDGDYWRLLPPGSHIVIAQAPGYSKVMKRVTIPLRMKKAGRVDFILHPLATGPKNFLPGPSRALPRFQDPQREPTQMDFEPPRARRQPASGSKPWWWAYFTSLSPYKPRWLLKY
The following text describes a protein:
Function:
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
Subcellular Localization:
Cytoplasm.
Sequence:
MKSNFYYDPETIRRVLGSTSETWYHKEPLITTITTSSTEAEENSLFVPLLGNRDGHEFIRDAISKGATYFLVEENHPIYKNLNLEEKSKAIPVKNTLTALGKLASFHRSRFDPIVIAVTGSSGKTTTKELLGNCLKNLEESALVVTEKNYNNEIGLPFTLFKISDQTRVVVCELGMNHKGEISRLSQIAKPDYAIITTIGTAHIEFLESQKNIAKAKGEIVEGLKKGGKLFYPNTGEYSKILKNKTRKHGNKLVLTKSDKIFSILQKKSSGFLLEYKNKKIQWNLPGEKLLENLSVAITCLEAIGTPQEWIQEGIHSFKSSNKRLDLQNGKYSVINDTYNANYESMISSLEVADQLADGKEFYAVLGDMKELGEYSKEFHKKLGKKCSEFQNLKGLYTFGTDSFWIQEEFVKRTSSPRFSEHFPGTQEGLSELIHKFLQTIPEGSIVLAKASRGIQLERFVEALPV
The following text describes a protein:
Function:
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Sequence:
MTDKDRLKQIILELSYEKRKVILASGRESDFYFDGKQTTLHAEGGLLVGKLFYEAIKDVEGVQGVGGITLGADPIATATSIAAFLDGRPMHAFIIRKEPKGHGTGQWLEGRKNLPPGSKVVIVEDVVTTGGSSMKAVKRAEEEGLKVLCIVSLVDREEGGRENIEQEGYELRTIFTKSELLA
The following text describes a protein:
Function:
Has enzymatic activity against both sphingosine 1 phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEKIKKQNNIGSYSSDKDGEYKKFRFSKTSIRGFLLKEYEREVPIIVKIQSYRNKFLDFYFKMASILGEEVFFILALPISTWCVATQLGVELCVVLALTIGGGNILKNTFTLPRPPPNIVWTNTAHQKDHGLPSTHTASAFGLTFYFLIYTYFLFPTIGESFNISLLSMFFIVLFWSTSVMFSRLYNGHHTPMDVIAGLIVAITSILATTYQLRYFIEGMVLSETFLFGPMLYIAILSAILFFHPQANTGPTPAYPETGLVCGASLGSLISLWLHAQHPCPLMNQELLLLEANYDSIVSTIHSIPLLLHGSRILIGLVLVGIAKVFSKKFFFFAYDLVIRANTNNEQSQPITTVSFDPNKKIIVTPTIEAFSKLFVYTCVSFTIVSMPYLFYYLNIQTSADVTRYY
The following text describes a protein:
Function:
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASTATNTDFFKTLLSPFSNGNAAQRSSRQNIVWLNRKQSGNNNRSLRVNGLFGGGKKDNKEDGQSKAGILGNMQNLYETVKKAQMVVQVEAVRVQKELAVAEFDGYCQGELVKVTLSGNQQPIRTDITDAAMELGSEKLSLLVTEAYKDAHSKSVLAMKERMSDLAQSLGMPPGLDGLK
The following text describes a protein:
Function:
Regulatory protein of the TOL plasmid xyl operons. XylS activates the xylXYZLTEGFJQKIH operon required for the degradation of toluene, m-xylene and p-xylene.
Sequence:
MFDTRLIRLPDQSHTHAHEHHQLVMSLAGRAEFEVNGCGGEVCRMRACLVPGEAGHVFAGVGDNRMLIIDLGEDNPTPEDPDLLARLFEAPRYPTLDADFQNLLSYAGAELARYGSDPLLTRALGGVLIRALHLRLFGEQQPLAASGPLDLERLDAHIVRNLARRITVAELAQVACLSPSHFHAQFKDSVGLTPHQYLLKVRLDCAARLLRESRLPLVRIAEECGFSSQSALTTAMRRYLGLTPKSLRKG