lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Key stress-response regulator that plays an important role in multiple regulatory networks in response to different stress conditions. Involved in preservation of envelope integrity and tolerance to surface stress. Essential for macrophage infection and facilitates intracellular growth of M.tuberculosis. Controls the expression of several protease and chaperone systems, including clpP1, clpP2, clpC1, ptrB, Rv1043c, acr2, clpB, Rv3269 and the clgR-pspA-rv2743c-rv2742c region. Also plays an essential role in RecA/LexA-independent DNA repair mechanism by inducing expression of DNA repair genes in response to DNA damage.
Sequence:
MAALVREVVGDVLRGARMSQGRTLREVSDSARVSLGYLSEIERGRKEPSSELLSAICTALQLPLSVVLIDAGERMARQERLARATPAGRATGATIDASTKVVIAPVVSLAVA
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSWDDEDFDIPSNSKKTVAASWEDEEDDGPVLESWDVDPEEEEKKKKEAKLQEAKRKAELKAKEDAEKAKKDAKRKELEQFDQLDERTRKELLKKAELNADLNNAADLFGGLGVADDNDDDDFDINEHPRERITKQQLAAAAASKRPALTKDTPLEEHPLFQPTNKQEYEKLRKTVGTSLTRLNEDSSLLYASSLAVDLIRDLSQPLSVENLRKVISTLNVVIKDKERQERQARLKKAGGTATGGAGKKKAKPLARPNVGGGFKKDAFDDMDDGQFDDLDDDDFM
The following text describes a protein:
Function:
Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import; Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASFQDVAKQFTEFYYNQFDADRKQLAPLYRDTSMLTFESSSVLGAPAIVEKLGSLPFETVKHQVSTLDAQPSGDHGGILILITGALLVDEEQRPMNYSQAFQLMPDGAGSYFIFNDVFKLVFG
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFPDITPSLKATMPDLRGRLLANQSLAELTWFRVGGPAQVLFTPADEDDLAYFLAHLASDIPVYVVGVGSNLIVRDGGIAGVVIRLAPRAFGEASASGDIVTAGAAALDKRVAEVAASANIGGLEFYFGIPGTIGGALRMNAGANGGETKDVLIEARGVGRDGTKHVFSNADMKFVYRNSGVDPSIIFTSARFRGEVKDADAIRARMAEVQSHRETAQPIREKTGGSTFKNPPGHSAWKLVDAAGCRGLRVGGAQVSEMHCNFLINTGDATAHDIETLGETVRARVKANSGIELHWEIKRIGVS
The following text describes a protein:
Function:
Regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MQSGEESRLGIKCASLHEELTQIVIDQDVGPLQRVPASEFLARLVEHMGQTIPREVFGAEAETGTRDLERLGAIVAYIDENFAAQNVLPFTIQRICELCYHPLHYFRVGELRKFVNALEKVCYVRSSWSAGYGAVPSPAEGTPTREASVDVSMSKIPWLPDDGGRDLRQFIEKIESIVSVNFGYEDDEDEGRDAAIQEYYDNEGAGDDEDDDQDYVDEDSATSEDEEEDVEEEEEEEGPEPEVGLEPVHAESAPEECVGTNKRTTAEREDCHMQPCAAAHSTDGAHPCGLKRSKLQEDGATMASPPDIVAEGGSHDPQVVDASKPPQLTTSATNVSCNASIEATVSLDDDSTAGGE
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MLWEDFIEKELIGSGHITSCAIIESEYGDTLASSKNWDLKENERSNIIDFFDSPDDEKLRFTINEVKYHVTSTKENVILGLAAGTRIALCKRGEYIVIGFTDKNDKFEDIARVCKNAVNYLNENSKPE
The following text describes a protein:
Function:
Together with tsc2, required for uptake of various amino acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1.
Subcellular Localization:
Cytoplasm.
Sequence:
MPLQSLVKALWNVLHEEESEGYPDLTELIAEVESYQQRYPKQNPTNSQKIRHILDEIYEKTPFNNTRRRILWLAVLKTVIPLLILDRQAVGEWWDQIFFPFLNSPTQLKPVFSDLKSILFYILIFHDEDEWGGDLRRECAEETITRLVDLYVSKAIENLGDVESQEQRNQTIECLVNVLVHYGIQRPKELSSCFCHHFLNPPTRIPILSVMVEVIRRQGPRLYEIPQTGFYDLVLKCAEFDTSPILLSYALSFILMILSHICNSLDDSLYRLFCIYLRFSMIDPTSGFPSSTASGNWEVFHDFMSTYASTTTSQTDSSYNDVHDIVGSSQPDYLESLDYSQLFSILYALYPINFLEFLRDPKLYASKHNFQIRYSFNQELLSTKSDGLLGRHLAHSNFLKYTAETELTDKSRWTRLDSIAVVALCNSLNAVGIAESVMDPFGGKLPTTYEETSSATGLLAYPNESHDIASEPFSISWPQNPSISGSVHSATTFDKAQLSNTEDSYDNISHGTSYSEGVSSIHMVKGERGSNNLELTSESLSSTNDTIRRLQRDLLFLQNELRFEKFVRQQHLQNIGKLHREHILDMAVESERQKLLLTNKRYKAQIELLNSEIDKHRSESQAALNRRVKWENDFNNKIKALREEKKAWKSEESELKSSIESLISQLESIRNSQIDIAFSKNQLELKLQLYETKLKEYEQHLSCVNISKKQVSSSSDTSFGNTKMDSSMILSNSEAVSDEQERELIESEKHRMKLESENLHLQANIELLKKDLEAINVVYEAKIFDLEKRLSSEANAPELHNPVNLNYDAQLSKISEIKENYDELLTRYRELEGKFLESQAEVEELKNFQKPLVDTGSSIHSSPGLQQSKFIIRNDSLHPKVGPPRRQSTDTSRSTFRQY
The following text describes a protein:
Function:
May be involved in the transport of nicotianamine-chelated metals.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDASIGDPRLTSVEAAFEKNPLPGFSWLVTPRAMAVAVLLGIVFCFVGMRIQMMTGFVPALNMPVTVLSFFLLKVLARQLQKWRLTVVPFTRQENMFLITCVITCLNLAITGGFATALTGMGTIVAKTLADDLDPRDIIDYIPTGKLIIYFFLIGMAGVLSNIPLNQIMIIDYQLLFPTGSVIGHLINSFHTPEGAYIAKMQVMTIFKVFFGSFSWSIFQWFYSSGSGCGFSSFPTFGLELYKRRFYIDFSATYIGVGMMCPHIVNFGLLFGAIISWGFLYPYLETKHGEWYQTDSPSNLDGLNGYKVFISVTLIVTDGLINFLILVTSAAINFYHIRQQQQQTSGLASYISKNPSMNYDERKRIEMFLSSKIPMFVPVAAYVAWTAISMVAMPAMFDQIKYYHVGVLYLAIPVVGFCNTYATGLTDWSVSNTYAKFSPFIFAAWIARPGAIVASLLVSGITMASLHVSSQAMQDLKSAHMTLTSPRAMIAGQVFGVALSSVVSPCIFRAFEKAAKPGAPLGSKDSVYPCPYAGLYRAICIIGMGGVKGLPKYCVELCVIAVLVTIAIDALVLVSQLKGWRLHLYIPSMTVIALPFFAGSYFTLDMCLGGLLLLLWKKIDTMSAEILSAAVAAGLICGEGLFTLPSALLNMFKVLPPMCMKFLPSGQEVEVVDSFLNSSGGTVPKT
The following text describes a protein:
Function:
Involved in the regulation of flowering time under short day (SD) and long day (LD) conditions. Functions as a floral promoter by negatively regulating GHD7, a repressor of the photoperiodic control of flowering. Acts as a floral activator in the LD photoperiodic pathway. Involved in blue light-induced activation of EHD1 expression to promote flowering under SD conditions.
Subcellular Localization:
Nucleus.
Sequence:
MATRGGGGGGGGKEAKGKVMGPLFPRLHVNDAAKGGGPRAPPRNKMALYEQFTVPSHRFSGGGGGGGVGGSPAHSTSAASQSQSQSQVYGRDSSLFQPFNVPSNRPGHSTEKINSDKINKKISGSRKELGMLSSQTKGMDIYASRSTAEAPQRRAENTIKSSSGKRLADDDEFMVPSVFNSRFPQYSTQENAGVQDQSTPLVAANPHKSPSTVSKSSTKCYNTVSKKLERIHVSDVKSRTPLKDKEMEAAQTSKNVEVEKSSSFHASKDMFESRHAKVYPKMDKTGIINDSDEPHGGNSGHQATSRNGGSMKFQNPPMRRNEISSNPSSENTDRHYNLPQGGIEETGTKRKRLLEQHDAEKSDDVSRLLEQHDAENIDDVSDSSVECITGWEISPDKIVGAIGTKHFWKARRAIMNQQRVFAVQVFELHKLVKVQKLIAASPHVLIESDPCLGNALLGSKNKLVEENLKAQPLLVATIDDVEPSLQQPEVSKENTEDSPPSPHDTGLGSGQRDQAATNGVSKSNRRATPVASDNKQNNWGVQLQPPQNQWLVPVMSPLEGLVYKPYSGPCPPAGSILAPFYANCTPLSLPSTAGDFMNSAYGVPMPHQPQHMGAPGPPSMPMNYFPPFSIPVMNPTAPAPVVEQGRHPSMPQPYGNFEQQSWISCNMSHPSGIWRFHASRDSEAQASSASSPFDRFQCSGSGPVSAFPTVSAQNNQPQPSYSSRDNQTNVIKVVPHNSRTASESAARIFRSIQMERQRDD
The following text describes a protein:
Function:
Acyl-CoA ligase involved in the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893. The peroxisomal acyl-CoA ligase 891 converts the intermediate MFDHMP-3C into MFDHMP-3C-CoA which impairs its diffusion from the peroxisome. The first step of the pathway is the synthesis of 5-methylorsellinic acid (5MOA) by the cytosolic polyketide synthase mpaC. 5MOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHMP) by the endoplasmic reticulum-bound cytochrome P450 monooxygenase mpaDE. MpaDE first catalyzes hydroxylation of 5-MOA to 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoic acid (DHMB). MpaDE then acts as a lactone synthase that catalyzes the ring closure to convert DHMB into DHMP. The next step is the prenylation of DHMP by the Golgi apparatus-associated prenyltransferase mpaA to yield farnesyl-DHMP (FDHMP). The ER-bound oxygenase mpaB then mediates the oxidative cleavage the C19-C20 double bond in FDHMP to yield FDHMP-3C via a mycophenolic aldehyde intermediate. The O-methyltransferase mpaG catalyzes the methylation of FDHMP-3C to yield MFDHMP-3C. After the cytosolic methylation of FDHMP-3C, MFDHMP-3C enters into peroxisomes probably via free diffusion due to its low molecular weight. Upon a peroxisomal CoA ligation reaction, catalyzed by a beta-oxidation component enzyme acyl-CoA ligase ACL891, MFDHMP-3C-CoA would then be restricted to peroxisomes for the following beta-oxidation pathway steps. The peroxisomal beta-oxidation machinery than converts MFDHMP-3C-CoA into MPA_CoA, via a beta-oxidation chain-shortening process. Finally mpaH acts as a peroxisomal acyl-CoA hydrolase with high substrate specificity toward MPA-CoA to release the final product MPA (Probable).
Subcellular Localization:
Peroxisome matrix.
Sequence:
MFFTQPPHLVKAEELKQEPPKGTAYSVAIPGTEQPGRSRVYRAWNAQKELLTTLDPQVTTAHDMFESTANRQPKNHCLGWRPYNSTTKTWDPYQWLTYETVQKRRAAFGAGLVELHQKHNCHRPGQYGVGLWAQNRPEWQITDLACISQSLYSVSIYDVLAPDATEYIINHAELNCVVTSLPHIPTLLKLKSSLPNLKMIVSLDPLDGPEQNGHSKRALLESMAAGLDLAIYTIDQVEELGLASKRGYNAPSASDIVTINYTSGTTGPPKGVVLTHGNAVAATSCGLTTIGQARGDTMCSYLPLAHIYARLAEHTAFWGGARIGYFHGNIVELVDDLKLLKPTGFMSVPRLYSRFGTAIRAATVEQPGFKGALSRHIVAAKMANMKNPDPSKATIKHALYDRIWAKKVAAALGLERAKYMISGSAPLDPTLHNFLRVATGTDVVQGYGLTESYASATAQSTQDLSSGNCGRLAPCTEACLVSLPDMEYSVEDKPFPRGELLLRGNNMFREYYKNDDETSKAVTEDGWFRTGDVCTVDAQGRFIIIDRRKNVLKLAQGEYISPERLEGVILSELGYVAQAYVHGDSSETFLVGIFGVAPDLFAPYASKVLGKTIAPTDVEGLKEHLNDDKLRRAVLRDLERVAKKHKFAGYERVRNVSLKVDPFTVENNLLTPTLKLKRPPVVKMYRTLLDQLYGQANEEQSAPRAKL
The following text describes a protein:
Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).
Sequence:
MERFLMQSSLSTSSLIYPHGSYDSSCNYCDAGEDKKGRICYGMVADQLTCEDYQLLIDQGWRRSGTFLYKPNNSDKKTCCPQYTIRLDTSSFKPSKDNKSTIKKFNNYILNNIIKEKDSSTTSTTKDIINTTQIKSNTKNNNNKTNDENIIKLNNDIIEIILNNEFINKFNEQDKKILKENLKIKINSNKMIKETGSYSLSFGIFNKYRSELNQHSITIDQIINFTILEFNKTINNSDYQFNLEKGQNNHINFKMINSSQILNDSTKTKTLNIQNNSNKNSTTTATTATTTTTTTNEPKHKFEISIHKPKCTDEVFSLYCKYQKIIHKEDDEKTKSGFKRFLVDSPLIPIIHPDESYDDYVYDGKDDDDDDDDKDEKEDDEDEDQEDDEDEDDGNNEDEKKITKENKEKEIKNHIYKIGKKSKTLKTRKFGEIKTPKPGYGSFHQYYRLDGKLVGVGVIDILPECLSSVYFFYDPDFNFLSLGKYSALNEIEWVQKVSQSIPQLKYYYMGYYIHSCQKMKYKANYQPSQLLCLETFKWVEFKKAISFLQPDKKYSRFYFDENENNNNEKLTYFEKEPELLERVKFRQKNFTFHFSDVSVRFQNLLKDQVIDYINHVGPELTKELIFYFK
The following text describes a protein:
Function:
Probable regulatory factor for several RNA polymerases. Effector involved in facilitation of Pol V transcription as RNA scaffold and recruitment of silencing complex to target genomic sites.
Sequence:
MDGVGESSTQNEVEEKPVIVRVKRKVGQSLLDAFWLEINERPLKRPTLDFSKLSISDSGERGPSVAEDVKPKKVLVRHLETVTDSETTADIIHSFFESDHNEKSCSKGKFEERKIAFKKDNRKEQRLTKSVQKQQIASENARFEQIWRSRKGNKEGIHEKCHFFDVIRVDTEERRDNAQEFTSLEDQKMLASFLPLLRECIPTAAEEIEADIQSSHTEEYVYDYYAVNEEMDISEDSSKNQFPLVIVEDEEEFCDGSDESDYDSEDSNAEDHPKTDYPEEEEEEEEEDDDDDDDDESEEEKSEASDESDDEETSKRHVRSVLGDDEFDDYAEDVYGYSESDEEFES
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MDADLVQMQKKLADYQNALFKEGILDSQYLELHELQDESNPEFVVEVVYLFLADSEKLLDDLSGDLIGAPRIKNACIEFQKFCQEKNIRGCLRYLQQMKQEFDLVKSKLKALFALEQNVVAAGGLIPKMQPIDLID
The following text describes a protein:
Function:
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of embryonic mitosis. The CPC complex has essential functions at the centromere for ensuring sister chromatid cohesion, recruitment of the CPC to kinetochores, and chromosome alignment and segregation. There is no function in meiotic histone phosphorylation or spindle formation.
Subcellular Localization:
Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with and is required for the correct localization of the CPC components Aurora B kinase and Incenp in mitotic cells. Is absent from spermatocytes undergoing meiosis.
Sequence:
MPRTKIPKNSKRNREVANREEKVRLYELKMDSRLISIDSLETKFLSAVDHQVKTLLGQVQKELANLKMPEVLRLFEELDRFSDFKASDQTQLLASMSMSGSAIEGHAPSATGSRNDEEDSSIGASGGSILAAHTGSLLRSTKAMRTPGPLHSARARRARRSRSACGDLNILHSAKPPSISSSSSSSRNSRSKLRTPMASRAKAFSADRTPLKQKQMRSGSPTTPPMAFLRYPKPGEVALSKYGSPMVAQVMPDKFANVNIPIRNGVLSLRPKKLDADEVESNLLENLDEDTLNQIKTLHENLQMIVNKASQAVFK
The following text describes a protein:
Function:
In vitro catalyzes the addition of water to fumarate, forming malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer maleate as substrate.
Sequence:
MATLTEDDVLEQLDAQDNLFSFMKTAHTILLQGIRQFLPSLFVDNDEEIVEYAVKPLLAQSGPLDDIDVALRLIYALGKMDKWLYADITHFSQFWHYLNEQDETPGFADDMTWDFISNVNSITRNAMLYDALKAMKFADFSVWSEARFSGMVKTALTLAVTTTLKELTP
The following text describes a protein:
Function:
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MARLPVGIRFIVSFSRDQWYRAFIFILTFLLYASFHLSRKPISIVKGELHRYCAAVNEGEVEFNSQNQKAGDVPPHQRPDNETDCGWAPFDRDNYQQLLGALDYSFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSFGFYVVTQIVNGLVQTTGWPSVVTCLSNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTCWGLSFVVPGAIVAAMGIVCFLFLIEHPRDIACSSTLTAHSKGYENGMHRLRLQKHVLMEKNKPLDPEMQCLLLSDGKHSAHQNHTIVLPADAGSGVAAISFTGALKIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDAQKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTISKMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKSLKGNSHALATVTAIIDGTGSVGAALGPLLAGLLSPSGWNNVFYMLMFADACALLFLIRLIHKELSCPRSAMGNQVPFKEQ
The following text describes a protein:
Function:
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis.
Subcellular Localization:
Endosome. Lysosome. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle, COPI-coated vesicle. Endoplasmic reticulum.
Sequence:
MAALDLRAELDSLVLQLLGDLEELEGKRTVLNARVEEGWLSLAKARYAMGAKSVGPLQYASHMEPQVCLHASEAQEGLQKFKVVRAGVHAPEEVGPREAGLRRRKGPTKTPEPESSEAPQDPLNWFGILVPHSLRQAQASFRDGLQLAADIASLQNRIDWGRSQLRGLQEKLKQLEPGAA
The following text describes a protein:
Function:
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). eIF-5 is essential for cell viability.
Miscellaneous:
MISCELLANEOUS: Present with 48300 molecules/cell in log phase SD medium; MISCELLANEOUS: [Isoform Short]: Produced by alternative initiation at Met-18 of isoform Long.
Sequence:
MSINICRDNHDPFYRYKMPPIQAKVEGRGNGIKTAVLNVADISHALNRPAPYIVKYFGFELGAQTSISVDKDRYLVNGVHEPAKLQDVLDGFINKFVLCGSCKNPETEIIITKDNDLVRDCKACGKRTPMDLRHKLSSFILKNPPDSVSGSKKKKKAATASANVRGGGLSISDIAQGKSQNAPSDGTGSSTPQHHDEDEDELSRQIKAAASTLEDIEVKDDEWAVDMSEEAIRARAKELEVNSELTQLDEYGEWILEQAGEDKENLPSDVELYKKAAELDVLNDPKIGCVLAQCLFDEDIVNEIAEHNAFFTKILVTPEYEKNFMGGIERFLGLEHKDLIPLLPKILVQLYNNDIISEEEIMRFGTKSSKKFVPKEVSKKVRRAAKPFITWLETAESDDDEEDDE
The following text describes a protein:
Function:
Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. Binds to the 23S rRNA (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MDTYTSAKINWFPGHMKKIHDQLKKLSSQIDGIIEIVDARAPTLTHNSEIISYFLNKPKLILALKTDLAQYKPNKKILFGSLKEPFKLKKKVLKTLTTLFANKRQQLKAKGLLIKQFRLAVIGMPNVGKSSLINLLINKNHLKVANRAGITKSLNWIQISPELLLSDTPGVFLKRIDEIQIGYKLVLTNVIRREVVNIEEVGMFAFNYLKKHYKQLLPFEADSFINFLEKFAKVRGLIKKANELNTNLACEIFINELINGKYGKLSYELN
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. This subunit may anchor the endonuclease complex to the nuclear membrane. Probably carries the active site for 5'-splice site cleavage (By similarity).
Sequence:
MAENMTIATMAQPSESPSKSGEEAPASTNPAATSAPPRPPRVPYHQIYKLPAPIRTFPLPTFYPSNPLSLFHLAVAWLRQVLLPPPAEPSVIHEGIWDPDTRSVHVKDPKSIRALWEQGFYGKGSLSRSEPNWFKRELSRRGLDGTTVSEERTASRREERRQVKWERAKAELEAIEKQKHEEAKLNSETVNAAIPEPPAAEIEPEPEVLLSSLPDHVLSATSTIPLSRAAPTNEFVPKTVAHGHVEPKPPVGPLELLALPNSYALVRGEELALSQPEPAPTEENVRKELKAPVGPIELLALPNSLVDLVALSVVSVLSEDAGVDEDESSTEDQLEASALTNDEPETSATEANDSTSSSSPPHTDGLPDSQPTQENVPATPERRKSVRFSSTVESTTFQHTDAASEVKNNNGSSDVEVFSSFVSAVEKPVILNVEPTVISQELVDKEHFQLAPEEAFFLTFGLGALRVVDPVTEAPISNEQLLIKLRANSYFPPRSVDNLSPEDPFLVQYAVYHHFRSLGWVPRHGIKFGVDWIIYQRGPVFDHSEFGIMVVPSFSDPRWSEFEHEESKKTWSWLMGVNRVLSHVLKSLVLVYVDVPPPPVFDEEMKKGGIAAALKKFTIREVMVRRFSVNRNR
The following text describes a protein:
Function:
Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).
Subcellular Localization:
Cytoplasm. Preautophagosomal structure.
Sequence:
MNPYQRASPRTASPASNLQTNPTRTNNPRHSADRNSYFDNPPYNDRGSEDGEDDMASRGDHMAETDQRQYQKINQVIQNFFTKSALSIVSSRVILPTSFNKNGDIRQNKWFNVILDDSDELQLRLTEWKTMDAMAGQHPPLYIEVYLDISGLGHKQSLVVHDEDGKRWDVAAALNAAQPTSRASSRPARPTQIVIERWKIYVGDIDSVHPSDLTEPLPNVYKKAVVLFRGLYANLRLLPAFKYNKSMAKQPANHTSLKLNYRILNGASERPQLDTLSLPLCPSTDPITETAHIGSTNSPIGPLCISVEYRDACEFSVEDSESLLSDQFMGLDDTYLEQKPRAAAPVPGSLPVDKLNTQETPDVGQAYGSLSTFHQVGPPTGTSPISALRAARDMPSSSPIETPPQKLPPNHRTAQGSKSSLRSNDTSSFQRRTSVSFQPFKAGSLSSSPAPGPAGPASPSSSLGRPTSAFGRNINIVPNSLNQPRNRTSLNALPQAALRAPSLPNDNAIASSASSSPKPAPITRYSSSFGHRRGKFSTGGSKTEEDALSSGKGSATSSLQRGSDTLNDGEGGSSGEMRSEDDNISDFLKLLEAKKDLKSFNRSDSSTRDATMRKTTAQLGKYQRMRDSHAQLSDSVSSSTMLHRSSSSSSRQLSSVPAMIHGTSISTASSPGKPISPHTPHTPAIPSRLSANSIIEYDQPHRSRNHRSRSRSGRTARGQGPENLEEQSEVEDDAAGIDIPLSPRPWNYQRRSSSVAQQNRNLPEDEPDMFGVRAASLPVEEGDRARDLHRITSTDLTSSGLFAQTESLASASRDNQAPDDGDSRDDLPRASSTSNTPAKRGTYSSNLRGRGGFFSQGSSTTGSTGGTSSTERQSRYNFNSRAANLDDDEPLLFQMSEIGAGGSRRSLEEARGGSSTGSARGRNSPWGGR
The following text describes a protein:
Function:
Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It may supplement intracellular myristoyl-CoA pools from exogenous myristate. Preferentially acts on C12:0-C16:0 fatty acids with myristic and pentadecanic acid (C15:0) having the highest activities (By similarity). Appears to play a role in the maintenance of cell viability during stationary phase.
Domain:
The FACS motif is required for catalytic activity and substrate specificity.
Sequence:
MKVQSKAISKPKEHESAIYRNANFPDHLVETYSDDVHTLFDVFRHSVKQFGNKKAMGYRNLVKEHVETKMVTKVVDGEKKEVPKSWSYFELSDYNYLSFNDIYDKALRYAGALRKLGLNKGDKFELYAPTSAFWLLTAEACLSQSMTIVTAYDTLGEEGLLHSLRESGVRGMYTEGHLLKTLVNPLKEIESLEVIIYRNDAKEEDIKTIQEIRPNLKLIKFADFEKMSPPVEPDPPSPEEICCIMYTSGSTGLPKGVILSHKNMVAIVTAIVKHVPEVTSKDYLLAYLPLAHILEFAFENICLAWGGTIGYANVRTLVDTNCRNCKGDINTFRPTIMVGVPAVWEMVRKGIMSKLNAASAVKRSVFWTAYYTKAKLMRHNLPGSCVLDTAVFNKIRSMGTGGRLRYTLSGGSALSPDTKRFLSIVLCPMLIGYGLTEISAAAMVQNPACFNLDDSAGSLLPCTEMKLVDCEEGNYNSHGHPPRGEIWLRGPSLTRGYLNRDKENKESFTPDGWFRTGDVGELTPEGLLRIIDRKKNLVKTQNGEYIALEKLESRYRTSSLVSNICVYADQTKVKPLAIIVPNEPVVRKLATEQAGLSPDASWEEVCHNKKVRQLVYDDLIRIGRSHHFANIELIQNVVLVPIEFTPENGLVTAAQKLQRRKILDRFKKEIDAAYAE
The following text describes a protein:
Function:
May act as a component of the auxin efflux carrier.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVSWKDIYLVLEATVPLYVAMILAYLSIKWWKLFTPEQCSGINKFVAKFSIPLLSFQVISTTDPYDMNIKLIYSDILQKSLALLGFAAISKACCAEKFDWLITGFSLSTLPNTLIVGIPLLKGMYGEQAGKLLSQIVVLQSLIWYTLLLFLFELRAANGMATTTSSETTGLIWALVGFRWHIRLPLIVSNSIRMLSDGGLGMAMFSLGLFTALQTKIIACGAKRMLLALAIRFFLGPALMGMSSYAIGMRGVLLKIAIVQAALPQGIVPFVFAKEYNVQADILSTAIIVGMMVAVPVALAYYFAMIIPAIK
The following text describes a protein:
Function:
Heme-binding chaperone that may be involved in cytochrome c maturation in mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space. Note=According to some authors, CCME is a peripheral mitochondrion inner membrane protein with the hydrophilic domain oriented toward the mitochondrion intermembrane space.
Sequence:
MAARLLFRRSSQILRSIQRNPQISSSFESPPCPIFHSLTTASPDPSRLSSLTFLRSLSIARRGPTRPKKIDIGAKARQMQNRRLWTYALTFSCIAGFVVIVLNQFQDQLVFYLTPSDAMEKFAENPTKNKFRLGGLVLEGSVAQPAASQEMEFVITDLITDILVRYKGSLPDLFREGHSVVVEGFIKPYTDEVRKEVSTKPISKKARNLDCFFSATEVLAKHDEKYMPQEVAAAIEKNKKIIEAAATEQAAEVAAS
The following text describes a protein:
Function:
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Subcellular Localization:
Nucleus.
Sequence:
MSDAAVDRSSEIATKDLKEKKEVVEEAENGKDAPANGNANEENGEQEADNEVDEKVEEGGEEEEKEEEGDGEEEDGDEDEEAESATGKQAESSPAPNER
The following text describes a protein:
Function:
Cytochrome bo(3) ubiquinol oxidase is the terminal enzyme in the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Catalyzes the four-electron reduction of O2 to water, using a ubiquinol as a membrane soluble electron donor for molecular oxygen reduction; ubiquinol-8 is the natural substrate for E.coli. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron and generating a proton motive force. All the redox centers of this enzyme complex are located within the largest subunit, subunit I. Protons are probably pumped via D- and K- channels found in this subunit.
Miscellaneous:
MISCELLANEOUS: Ubiquinol oxidase catalyzes the terminal step in the electron transport chain.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MFGKLSLDAVPFHEPIVMVTIAGIILGGLALVGLITYFGKWTYLWKEWLTSVDHKRLGIMYIIVAIVMLLRGFADAIMMRSQQALASAGEAGFLPPHHYDQIFTAHGVIMIFFVAMPFVIGLMNLVVPLQIGARDVAFPFLNNLSFWFTVVGVILVNVSLGVGEFAQTGWLAYPPLSGIEYSPGVGVDYWIWSLQLSGIGTTLTGINFFVTILKMRAPGMTMFKMPVFTWASLCANVLIIASFPILTVTVALLTLDRYLGTHFFTNDMGGNMMMYINLIWAWGHPEVYILILPVFGVFSEIAATFSRKRLFGYTSLVWATVCITVLSFIVWLHHFFTMGAGANVNAFFGITTMIIAIPTGVKIFNWLFTMYQGRIVFHSAMLWTIGFIVTFSVGGMTGVLLAVPGADFVLHNSLFLIAHFHNVIIGGVVFGCFAGMTYWWPKAFGFKLNETWGKRAFWFWIIGFFVAFMPLYALGFMGMTRRLSQQIDPQFHTMLMIAASGAVLIALGILCLVIQMYVSIRDRDQNRDLTGDPWGGRTLEWATSSPPPFYNFAVVPHVHERDAFWEMKEKGEAYKKPDHYEEIHMPKNSGAGIVIAAFSTIFGFAMIWHIWWLAIVGFAGMIITWIVKSFDEDVDYYVPVAEIEKLENQHFDEITKAGLKNGN