lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for traffic between late Golgi and early endosomes. Required for endocytosis and maintenance of vacuolar structure (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein. Note=Late Golgi.
Sequence:
MSLYDSLLSNLQSINVDTRKKNADLKKLADGSLKFLYTNKNLSQDSLVSKLKGNEAFYKPFLFCCAKKIERHIYISLNSIQLLAINDALSPDILESLFNSLNAVIQLGQDSQLRVLQIIPIICTHYAASMKLPILISLFRICFNLHNSKNSVVSNAAAATLRQIVILVFDYLDYDTLAHKQEADLFLDSLSLFKGLCSLLSAGKSESLNVDHISTTFGLELLESILVNHHRLFQIPEFQDSVRKDLLPIITASLASMSDFPVALRISRILNIIFQHYVTSLTLDIEVIFSFIISSLDNSEAAWKKALFLEVLRSIFSNTNLLYLMYTLFDGNEGRKPIIKKLVTSLSRIVNEKPSVIGVGSRVVLADTFEDYSSTSSGNPPSSMEKVSGSFTGTKPEQIIGICRATILKTPCIEQFDKQEPPIIPFAYLVYLAMCSLASISNGIADFVFQFYEDVGKKEFTLLIEGIKCENFDSKEDSTARPQNIIKCQYGLISENWTSFLVAYSTFVSSALAVELLKFCLNSYVNFVSVCTLFGLETPRDALLTTLSNKAVPSNLLSGNMTHSASSSISHNGRLSTSTMFSVEGLKEAATTIAAIASYDSNHDEKQKCFSLREILFLRCLSSIAKVVGEKMGKGWKILFETFDKADIILNRSPTSKHLSTSSLNRVNSSNSNFQDSKSFSTLMDYELVSYKNELSELMYVTSSYSQPAYMEFLESLLAVITSSSVHPIQTLTAPRQSFNEDLLSANTKNSVYKTSANRSISGGIRLLRKSSEVFYSFSILETVCSCNLDRFLDSKLDHSGWSLISKSLSEVFKIINVAPELRTRAANCLANILVDVASRLSNENSPDSYAFQEIFFESLGMLLPVTEVSDNTSRGVEYDISTIGLEALVSILETVGHHVLHGWQYVFEMLRFNCLNGATCFGSEKGAKIVRLAFSCLQLICTDFLASLDTSNYLDLMDTLLVFCRQLEDANVSLTAVGLFWNVSDTLKNMFSTSDFSCAYNSVEDLYAFTSMKSKEILPEVLWIMLLVHLADLCENSWASVRNGAAQILFRIFNSQCSKLGTNAWASCCQLVIMKLLHSQPIQNVSDVNNKKDEDDHEQTSCLIISGIADVFSENMSLLLNVNGILDVLEEAFQLMLRLHSDIYPKICISNFKALRELSFSISEFGKENATFTLLIKLVFINWGRFCEVSFSERRLANISQEGLTLLIESVVFLLKAYNFGIEEIKDSLLQVRKAVFYEESTSFALDVDFLSSLQLAVESLTDLLISKFKLNHLVLELWSDVLTYAFNEEKTIRASLPTLICLSKKIFENAENVVENHSLDFLNRGTMQHMFESLLVPMRLKYRCPKASRVNQSTLPIWVLASKCFVRLMINCFKDLKGSDAIEDAEKMQCLFLLTVEATNSIISPNADYEYVWSLEDVFENEDVSSLKQLHNLWKPHLQLNCLSDEVAQYYITLCKGSFYYQMRNTEDMVISRSNLDIQKEAARNFFPSTESPVSNRRQRIAVDCFSILLDDYNSSYEHVSLTIRPILQSRLCWSLKRYVADKSVSGYLPLSKSQEMDMSTVAECLNNHPSLYSNPIHYLLRKAYHTTNASPVATSLNAILGQLTLKNEVLNAI
The following text describes a protein:
Function:
Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide. Forms a homodimeric channel where each subunit has its own ion conduction pathway. May conduct double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain and functional switch to the ion conducting state. CLCNKB:BSND channels display mostly a linear current-voltage relationship controlled by common gate. Mediates chloride conductance along nephron segments, namely the thick ascending limb of Henle's loop, convoluted tubule and the collecting duct, contributing to the maintenance of systemic acid-base and electrolyte homeostasis (By similarity). Conducts chloride currents in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing.
Miscellaneous:
MISCELLANEOUS: Compared with CLCNKA/BSND, CLCNKB/BSND is more sensitive to pH and less responsive to Ca(2+).
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLMALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNNRFSSKLLATSKPVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHFMNHSITTLAKDMPLEEVVKVVTSTDVAKYPLVESTESQILVGIVRRAQLVQALKAEPPSWAPGHQQCLQDILAAGCPTEPVTLKLSPETSLHEAHNLFELLNLHSLFVTSRGRAVGCVSWVEMKKAISNLTNPPAPK
The following text describes a protein:
Function:
Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia.
Subcellular Localization:
Cell projection, cilium, flagellum.
Sequence:
MGQDYYADLEVTRNAQDVEIKRAYRRLALKYHPHRNKESGAADKFRQVAEAYDVLSDPLKKGIYDKFGEDGLKGGIPPEFGSEAVWTEGYVFHGNAEKVFRGFFGGDNPFSEFFSSDGSEVNVSFGGLRGRGVKKQDPPIERDLYLSLEDLFYGCTKKIKISRRVMNDDRCSSTIRDKILTIDVQPGWRQGTRITFEKEGDQGPNVIPADIIFVVKEKLHPRFRREDDNLLFVSDIPLGKALIGCTVEVKTLDDRLLNIPINDIVHPKYVKLVPGEGMPLASDPAKRGDLYIFFDIRFPSRLTPAKKQLLRQALPT
The following text describes a protein:
Function:
Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
METSEWIVIIVSLIHVLCAPGTKVEESFNTQATHDLLFHMPTNLSNEQFQAIIMKTFSAIETVRCFLASSCELFPIFSHCQIVFVNASDEFRETLKSDLRVVESVLIYELNLDSVGARFFKNSSDEQGGPSTAEEMEIRENIRRVGSIFSVLNRILLLYRRHTEFSEVSFQFQGYRDRMCEFVIALIIWVLMCWNLDYDHTQFPGVVPRTFIGPIVLAIFSSPMSIMFRFWAIPKPFQLMLIRTTLGLINTVSVLYFARSVQWGFGRETAMFLRYILCSQFHFFFYLSRPLPNSFALCLVMIVFQRIFEERYRSAVRYATACVILFRCELVLLFGPLFLGYLVLGKLKTFGFDGAIAIGVRIAAACLAFSIPIDSYFWGRPVWPEGEVMFFNVIENRSHEYGTHPYFWYFYSALPRCLLTSVFLVPLGCLSDYRVPKILVPSACFIFLYSFLPHKELRFIIYTIPIFSLAAAVFCARIYVNRRKSFVRKLLNYGIILHLIVNVACTSLFLLIASKNYPGYDAFNKTENLKPEDLQHFDFLTLGTYGSNLREEVETKFMKYHRPLFFVNAFHEYKIKTSKSFPWVYPTIVYKEKAAILKNKNYRF
The following text describes a protein:
Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
Sequence:
MKKISLKTFRKSFNLSKSKEETDFMVVQQPSLAGDFGKEDSLFGSCYGKDMASCDINSEDEKGGKNRSKSESLMGTLKRRLSAKQKQKGKGGGPSGGSADEDTFSSASAPLVFKDVRAQRPMRSTSLRSHHYSPTPWPLRPTASEETCIKMEVRVKALVHASSPGPALNGVRKDFHDLQADTACQEQTNSLKSSESQDGDLRLHLDEHVPVVIGLVPQDYIQYTVPLEEGMYPLEGPRSYCLDSSSPMEVSALPPPAGGGSFPEDENQVDQDLVVAPEIFVDQSVNGLLIGTTGVVLQSPRASHDDVPPLSPLLPPLQTNQIQRNFGGLAGTDAHVAESVRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MSTSTLSSSILFITNSNISLNHLHQNLKFQTPPESSLLPTMAAKNTTIFSFFSTLIFFGLIHSNQIDALNTNYYDHTCPNVESTITSVVKKAMMNDPTVPAALLRMHFHDCFIRGCDGSVLLNSTGKNKAEKDGPPNISLHAFYVIDNAKKALESLCPKTVSCADILALAARDAVTLSGGPTWDVPKGRKDGRISKATETRQLPAPTFNISQLQQSFAQRSLSMDDLVALSGGHTLGFSHCSSFQNRIHNFNSKQSVDPALQSSFAARLKSICPAHNTVKKAGANLDSTPTTFDNRYYKLLLQGKSIFSSDQALVTMANTKTLVSKFASSQHEFEKAFVKSMIKMSSIHGGQEVRLDCRVVN
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSLKHAVHRRAHKERSQPKERKRFGLLEKHKDYVVRAKAFHKKEDYLQKLKEKAAFKNPDEFYFKMINSKTVDGVHKQAGDPNKYTQEELLLMKSQDIGYILQKVQSEKKKIEKLTATLHSLDSQPSNRHVYYAEDREDAKRILSETKSVGGFHAFEDLPDKIKRRTAASYRELEARRGRVQELEKVYNEMAMKQELQKKGKKRKLREDEIVCPSSRPVYKWKTERKR
The following text describes a protein:
Function:
Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division (By similarity).
Sequence:
MSSIARPPDPCLVAVVLIARSRAGPRFVFHYPPRPLADNALRPPKARRTSRSRSRQNSKGNDSTSSDDSHSSSDEDEEEAPSQNLNNSNNSNNNSYIAGSRRSSNFGLDDSNTLSENQRPGSISSSRAYLRKRGANSDAETDSGVGSDRQEDGSRESDGPNRVPWESILGLPVDVWEKLLSPSRSWHKRRFELGINDLAFVGWPVFVREDGNWRKQRRKKKKKQRAEWESGELGHNDATEDSQDDGNDAVAASTETLSPFSALHPISQRPSVPNSRSSQMSSEPLDADDKDMMTMFNVVFVLDPPLLEYSMRVREIYDNVIKKFSKALKWEQSRTNYVWRECQHILNIKEKAKEKRSSLNSLYADIISQSSLARAIRTLYTSISASKIASVTLSPDVSISLQIPPLTSTPYLPGPTDQAYPGLWLTTADSISPADDPMTDDNSAPHQVLAKHFALLLLDNEATIIKDVEAAGGALAPPLVHYIRCSSPTKSFVQISQISGMPLPTIQFLASHLVYWRRARAIPPLHQRDTYIVSPNCDLSKLEVASAAYKVAFPTLPSLPKMLSALSGTPRPYGNFIPSKDHKATYFLILAWLLRGGWVTQLRSFARVKVSPEIKMAVELAIRREEVDKYLSKGKPPVATSDKEDSVNDERTEGSDFDDASSSSSSSLASHGSGDATPMPNRFRADTGVDLTHSLLDQTASLKTSSLILLPHKVSPLESRWLDEIVARFPDNAPDFVGNTTEVDSATPIPAKSLKEVWPTYLKYFNGYDALEKIPVREGLKRKLVSQVLTRLGLVTGQSSTELDPREQVLVSFRHW
The following text describes a protein:
Function:
Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate (DAP) to form pyruvate and ammonia. In vitro the D-isomer of serine is degraded to pyruvate, though very poorly; other amino acids (L-serine, D- and L-threonine, D- and L-beta-Cl-alanine) are not substrates. In vivo allows poor growth on L-DAP or a DL-DAP mixture but not on D-DAP alone, this may be due to a poor promoter. DL-DAP is toxic in the absence of this enzyme, it may inhibit enzymes involved in the synthesis of pyruvate and aspartate, as well as amino acids derived from them.
Sequence:
MSVFSLKIDIADNKFFNGETSPLFSQSQAKLARQFHQKIAGYRPTPLCALDDLANLFGVKKILVKDESKRFGLNAFKMLGGAYAIAQLLCEKYHLDIETLSFEHLKNAIGEKMTFATTTDGNHGRGVAWAAQQLGQNAVIYMPKGSAQERVDAILNLGAECIVTDMNYDDTVRLTMQHAQQHGWEVVQDTAWEGYTKIPTWIMQGYATLADEAVEQMREMGVTPTHVLLQAGVGAMAGGVLGYLVDVYSPQNLHSIIVEPDKADCIYRSGVKGDIVNVGGDMATIMAGLACGEPNPLGWEILRNCATQFISCQDSVAALGMRVLGNPYGNDPRIISGESGAVGLGVLAAVHYHPQRQSLMEKLALNKDAVVLVISTEGDTDVKHYREVVWEGKHAVAP
The following text describes a protein:
Function:
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTETSTVSIASSAIVCVEADIKGEVIIKEGCVVHPFVVFDATKGPIYVGENNIFEEYAVIRNNSDGQPMIIGDWNIFQVHSKSSAKYVGSRNVIGVHAVLEDGCSVSDDCSVGAKCTVFSHQNLEPSVSVYAATNLSRTTKTPNMTSPHQIEFLRKILPSYHHLYGKKKAVATASASAAQ
The following text describes a protein:
Function:
Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVLNSDTQEDAKSGVEKFQVKILGDSSAQITEDVLSSSNVGITDSKLSGSASSASLTNGHAAPMYSAGIRNGNETWFEVGRSKTYTPTADDIGHVLKFEYSVVDAVTKSPVGQASTLQTNRVIPAPSPIPRRIIRVDGMGHLDLDRRMTSSGTFTALSYNVLSETCASNDLYSYCPPWALSWPYRRQNLLREIVDYAADIICLQEVQNDHYEEFFAPELDKHGYHSLFKRKTTEVSSGTTIDGCATFFRRDKFSHVKKYEVEFNKAAQSLTEAMIPTAQKKAALNRLVKDNVALIVVLETKVNNQLVDNLGKRQLLCVANTHVHVQQDLKDVKLWQVHTLLKGLEKIATSADTPMLVCGDFNSVPGSAPHALLAMGKVDPSHPDLTVDPLNILRPHSKLVHQLPLVSAYSSFARTAGLAFEQHKRRLDGGTNEPLFTSVTGDFVGTLDYIFYTADSLVVESLLELLDEESLRKDTALPSPGWSSDHIALLAEFRCCKNKSKSRH
The following text describes a protein:
Function:
Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MNSPIQLHKKFSTTVWHVLSWILYAVGAGPTAIISMGVYVPLIVMKNAHDHGFLRTDHTIPCSLYPEEPCSLNIVGPLWIDVSSIVFAASAISTFLQMAMMVSLGVICDYGNNRRYILFSCVIIGSISGIILSWSPSSFLLGKIVFLILVDLNFIISQSCYDSFLPIFLRFYPITRGPITLESALQDETDDLDSYITNTTIDSSEEEPYLLEHSLILNESAPPADVEDEHKAKIAARLSSVGFGSFFGAAILFQIIFTPILYKTNNNPIILPITVTVCSCWWLILSTPLCTIVTLPVENHSSDAILTLLYNSVKESYHSFKHAMSISSIRLFLFSRLFINCGIQTSLSSAVIFGKARLNLSNFQLTLLGMGISSFALLGTVIIPYLTEYFQLNSLQVVMIISILLPMAPLYGLLGYIPGFENAGIRTSADVFRATLFFGFFLGGAHSYCRSVYAQLVPSGKETRFFALYALISQTGVLFSHISLTLISNYTSDLRAVYIFVIVVMTLPLSSLWIMYQHSKTPNLHRSSS
The following text describes a protein:
Function:
Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs). Also identified in a modified version of SAGA named SALSA or SLIK. The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities.
Miscellaneous:
MISCELLANEOUS: Present with 7000 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MNGGGKNVLNKNSVGSVSEVGPDSTQEETPRDVRLLHLLLASQSIHQYEDQVPLQLMDFAHRYTQGVLKDALVYNDYAGSGNSAGSGLGVEDIRLAIAARTQYQFKPTAPKELMLQLAAERNKKALPQVMGTWGVRLPPEKYCLTAKEWDLEDPKSM
The following text describes a protein:
Function:
Required in all receptor tyrosine kinase signaling pathways. Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless. Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor). The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions. Maternally required for normal determination of cell fates at the termini of the embryo. Required for cell fate specification of the ventral ectoderm, in the developing embryonic CNS and for embryonic tracheal cell migration. Functions during imaginal development for proper formation of adult structures such as eyes, aristae, L5 wing vein and the tarsal claw. Dephosphorylates drpr isoform A which is required for the inhibition by drpr isoform A of glial cell engulfment of axonal debris produced following axonal injury.
Miscellaneous:
MISCELLANEOUS: The PTPase domain is interrupted by a PTPase insert which shares no homologies with other PTPase proteins. This PTPase insert is reminiscent of the kinase insert within the kinase catalytic domains of several receptor tyrosine kinases.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSRRWFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNGDFFDLYGGEKFATLPELVQYYMENGELKEKNGQAIELKQPLICAEPTTERWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKYDVGGGESFGTLSELIDHYKRNPMVETCGTVVHLRQPFNATRITAAGINARVEQLVKGGFWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTLIARKRAEEQSLQVGREYTNIKYTGEIGNDSQRSPLPPAISSISLVPSKTPLTPTSADLGTGMGLSMGVGMGVGNKHASKQQPPLPVVNCNNNNNGIGNSGCSNGGGSSTTSSSNGSSNGNINALLGGIGLGLGGNMRKSNFYSDSLKQQQQREEQAPAGAGKMQQPAPPLRPRPGILKLLTSPVIFQQNSKTFPKT
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAAVSGVVISGCSPARELGPGAPTVGPPTIGDRPRPEEGTEAEKQSRVGALLERLHAKHCASRPWQETSKVVRQAMEKRNVLNAGGHQLLLTCLETLQRALKVSSLPAMTDRLESIARQNGLGSHLSPSGTECYITSDMFYVEVQLDSGGQLVDVKVAHHGENPASCPELVQHLRERNFEEFSKHLKGLVNLYKLPGDNKLKTKMYLALQSLEMDLTKMMHMFRLATNANTVETILHGSVGLVTARSGGHLVTLQCYVSPYDVFEEETGALLNLTDSNVPRNLGVGVSVTIEGTSSVYKLPIAPLITGTHPVDNKGTPSFSSVTNSNCVDLPACFFLKLRRPLPFSLSFIHRMGNATGIPLFETAPPLAPLYELITQSQLQEEGGGALPPLAHNMRFYASLPGQQHCYFLNRDAPVQDGRCLQGALVTKVPFRHPAQVPALLDIIRHQAAYNTLIGSCVKRTVLKEDTPGLLQFEVCPLTDSSFSVSFQHPVNESLVCVVMEVLDSRQVSCKLYKGLSDALICTDDFITKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPAGSPGYGMGTGGGAAGGGGGAGASFPGPISTLFGMGLALKERHEGRGGHGDDFSKVTQNPILTSLLQITGNVGSSPTQAPPAAGHQPHHTPPPASSPASNTKNHPMLMNLLKDNPSQDFSSLYSSSPLERQNSSGSPRTDIMGGGSCGGGGGVSGGKTKKKRQRNPDKHHQHHQLEDDFHRELFSMDVDASQNPIFDVNLPGDGLDTPHSITPAPSQCGTPPTQQQQQQVAPPQPPPSGPSRMVRLSSSDSIGADINEILSDIPEQAGKMAAGGGGGHGPHHHGLGGGDDGGALGTPIRDSSSSGQGSAVFEADLFSAGSNENPFTDPVDLIADAATAATPNSDSSSNNFFPDTVDFNPELLAGPGFPQAYFEDSSPSADGDLDLVKGFGGGSQQHTPAGTPQNPTPHGRSTPDPSMKDPFEMSMVFGGSGGGGKPLLGGPLPAPDLADSHSGGGQSPLMMMGMGGGGGSDFKSDAKAKQQQLMRGGGKEGNGGGGGGGSGLGGASGGSSEGKQGKRSRTPSSDGKSKDKPPKRKKLDPEGKSPSHSSGGRPYTPPSGIGGSGGGSMGAGGGSKSPGSSGRSQTPPGGATPPIPKITIQIPKGTLTGGKTSSHGGYTSSSSAGGGGGGAAGGGGSKSHHSHSSSSSSSSGKMKGSKSDGSLGQGGGSKPGGGGGGCSGGGGGGGGGSQSKGSSQGMGGGKPGSSPITKHGLAGAGVVAGGGVGGGAKMKPQGGKPPASLINPNIKPNISPSHSRGVGAPDKLSSPMKLQQQQVPGTPPSSKAKSPMGSGGGGLGSGSKTSSGSGMGPQKQQMGGTSSSGSSSSSSSSSSSSSSSSSSSSSSSFSAGSQSQYGGGGGGGGGGGGNNNPNAKGKSPSRNKKPSLTAVIDKLKHGVGTGGXGPPSSKHGGEYMSKRDKGDKESKSKVSMSGVGSGDKKALDSKSGVVSSTGVAKIIISKPDGGSPSIKAKVTLQKPGEGSGEAMRSQLSGPKAYGSPLFSASTPKHDRCSPSHGRSPGYTPLNPDSESESGSSSVAEKSHQNSPSSDDDQALRPLQPPHEYMSSMPISSGEKHKKHKKEKKKQKERERERERDRDKEKKKSSSSCSTSSSHPLKADSWSRSPIAAPDPSLSLLGSDRPARPSPAYLRTEDDDLMDSALTGN
The following text describes a protein:
Function:
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIPSSPPRSSETAVDVDGVELDASHRPDEPPSSSSMHSQHHHVHRDTDNNNIIYDSPSSPSSPGLRNRRSASNNSDHPSIEMSAEVPVLDDFDESSFMHDNTHETPPQSQQTQPPPPSEPHQQTTNDAHVLHNFWRTFDDVVILSLFAIFGIVFRMLSATWFSLELAFVFSEDSALSTNLPLNCLSCFLLGLLCSGRDAMGIVYSKVLGGANPYGSNGRNILDIGKGAYRGVVDAGREGINRARGYKRHDVTSLPTIHTANIGFSNEETSEEVVSDHQSPSDSLHRRRSQHHSLAVLTASSSPRTRIHLPSSVYNNSNKNTTSPTALSPVSDTLAGESIAGLLGLDEDYRIGARYNNEDEVREVQLRALTRRIIASPSLMLFPAKKVDVDVMEHYQRSSSTELPLSSNNDTSQFEIVSLDDEEVPNSGQESGEPSGNITPSHQQSTNPRIDTIVSSTQQQTQGSNNTIGEDLDDMLQNISESLATLGRINVGDGWDVGTSAEDMKHDILLGLRCGLCGAISTFSSWNTAMVNLLRAGKIGEALIGYGLGIQLGIISYRFGQHLAVYFFVWRCRRETKRDERRGYGLRIRADTTDSDQSEETETAVDANTRRTAFELLSIRAVMTSVFATIMTTLFVAVFLFPKHQQFFISLLFTPFGCLARWKLQNAYNKKLPGFPLGTFACNMLSCLLSGSLGSFLAGNPGPEESIVLTSMIAGFAGSLSTFATFIAEVLALIDPIIFKFDGFVYATITIAWGILLAFFSSNAKNWADEI
The following text describes a protein:
Function:
Required during maturation of the 40S ribosomal subunit in the nucleolus.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAGGEQASHRPGLLKQQNKSHKNGRHRSKSEIDKNNKGRVHVKLASKRKNQELKRDERRRKANQIRSKKREDVLAKKRAIGGNDSAPFLSAIIPLGESANIQKLLKQIKECDADAKVEMTGSNVININVPRFRQNFSLIVPCPGDLYAALDACKVVDNVVFLISPPSDTDSCMSHSTTNEGPLGFDNSGEELLSAIMAQGLPSPIFVVNDIETISLKKRNDYKKLLMKQLDQMVPLEKLQVIENESDALRLLHHIGSQKQRPIYQRNMRCHFLCEEVNFKQNSDDPTVGSLIVDGYVRYQPLNVNGLVHIPGWGDFQMERIEVRREPGEFIFLEEANPAIQESLKSENDPDPMNGEQTWPYQEEMEGQTLEAVKIEDDEESEKKKRVPKGTSEYQAAWIKDEDDDKNEENAEEEEEDSDDWEDDYEDMSGDDGSEESHEEAEEDEMESVDNEGGDTDVYDKKVKFADEEEEFKKIKEAREDELFPDEVDTPRDTLAKVRFQKYRGLKSFRTSPWDAKENLPMDYSRTFQFQNFPRTRKRILKEERTGAKPGWYVRVHVKNVPSHLPASLQSGYPLTLVGMLPHEQRMSVVNLVLKRFKNARDQQAIPSKERLIFHCGYRRYAAAPIFSQHTAANKHKYERFFRPESVVVATLYAPIIFPSASVLVFREKKDGTQVMIATGSVLSVNPDRITVKRAVLSGAPFKVHRKSAVLRFMFFNREDIEWFKPVELRTKYGRRGHIREPLGTHGHMKCVFDGQIKSQDTVMMNLYKRVFPKWSYDPNVASPSPLYNHEVEMEDAANQLMV
The following text describes a protein:
Function:
Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification.
Sequence:
MLSWIRPSARLSFFHSKDNKLLLTKKPGESGVKQQVALADVCRSATPTKCHLNPFLFNGHLQTAWTAVKFDDVPVYYKRRMFEADNSMYKGHFAVDFVVEPYETPRDNAEATDEARRYTLPSGLPERTSFFSEEEFQALPSDDTKPMLVLLHGLSGGSHEIYLRHVLAPLIADGNWEACVVNSRGCSQTKITTGVLYNARATWDVRQTVKWLRKAFPNRPLFGIGFSLGANILANYLGEEGDACQLKAAVLCASPWNLDISSANLQKTWLGLEVYSKTMGSSMKRLFEQHVEEVSRNPRVDVEAVRNSTYLHEFDRALQCPTWGYPTEGAYYRDAASIDSMLAIRIPFFTVQAEDDPIASVDALPFQEMTQTPYGVMLTTSWGGHLGWFELGGDRWFVKPVTNFLNAMAKEIDLETPFIVEHPEKLPGHLANHFDLNKDADTAPKPDFDPMRRKLATKMVQ
The following text describes a protein:
Function:
Involved in the transport of hemolysin A.
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein.
Sequence:
MKTWLMGFSEFLLRYKLVWSETWKIRKQLDTPVREKDENEFLPAHLELIETPVSRRPRLVAYFIMGFLVIAFILSVLGQVEIVATANGKLTLSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQIRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTILARINRYENVSRVEKSRLDDFRSLLHKQAIAKHAVLEQENKYVEAANELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDSIELLTLELEKNEERQQASVIRAPVSGKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNINLDAIEDQKLGLVFNVIVSVEENDLSTGNKHIPLSSGMAVTAEIKTGMRSVISYLLSPLEESVTESLHER
The following text describes a protein:
Function:
Plays an important role in extracellular electron transfer. Can transfer electrons to insoluble Fe(3+) oxides as well as other extracellular electron acceptors, including Mn(4+) oxide and humic substances. Essential for direct interspecies electron transfer (DIET) in cocultures with G.metallireducens.
Subcellular Localization:
Cell outer membrane. Cell surface. Note=Loosely associated with the cell surface. Localizes along the pili.
Sequence:
MKKGMKVSLSVAAAALLMSAPAAFAFHSGGVAECEGCHTMHNSLGGAVMNSATAQFTTGPMLLQGATQSSSCLNCHQHAGDTGPSSYHISTAEADMPAGTAPLQMTPGGDFGWVKKTYTWNVRGLNTSEGERKGHNIVAGDYNYVADTTLTTAPGGTYPANQLHCSSCHDPHGKYRRFVDGSIATTGLPIKNSGSYQNSNDPTAWGAVGAYRILGGTGYQPKSLSGSYAFANQVPAAVAPSTYNRTEATTQTRVAYGQGMSEWCANCHTDIHNSAYPTNLRHPAGNGAKFGATIAGLYNSYKKSGDLTGTQASAYLSLAPFEEGTADYTVLKGHAKIDDTALTGADATSNVNCLSCHRAHASGFDSMTRFNLAYEFTTIADASGNSIYGTDPNTSSLQGRSVNEMTAAYYGRTADKFAPYQRALCNKCHAKD
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MNPKIETFNFYYQTYFKDISKIEFIEHVPDEILIDSNDKDNNNKLIKIEQSTLGISVSAIALLYPICLELVKNEHYEDQASWMILFLNGENYTAWGIRQRLKKEEDLKLTELICIRFPGSSCSFNYRQQFESTYENETRFFLKAFQKKNRSYHLWTYRMKYIKKISQEDHTIYEKECDLMKNLAEKDVHNFSIFHHLMICSKQCGMELMKWALELRDSFSLMYQGQVKDCEIDFKALQSLNQFIKHLQ