lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
Subcellular Localization:
Secreted.
Sequence:
MATAFWLLLFLLGSLHVLTAAQNSSQSEWPIHDNGLSKVVQWDHYSFYINGQRIFLFSGEFHYWRIPVPALWRDILEKIKAIGFTGFAFYSSWAYHAPNNQTVDFSTGARDITPIYDLAKELGMYIIVRPGPYVNAEASAGGFPLWLTTGAYGSTRNDDPRYTAAWEPYFAEVSEITSKYQVTDGHYTLCYQIENEYGQQWIGDPRDRNPNQTAIAYMELLQASARENGITVPLTGNDPNMNTKSWGSDWSDAGGNLDTVGLDSYPSCWSCDVSVCTGTNGEYVPYKVLDYYDYFQEVQPTMPFFMPEFQGGSYNPWDGPEGGCTEDTGADFANLFYRWNIGQRVSAMSLYMMFGGTNWGGIAAPVTASSYDYSAPISEDRSIGSKYYETKLLALFTRCAKDLTMTDRLGNGTQYTDNEAVIASELRNPDTNAAFYVTTHLDTTVGTDESFKLHVNTSKGALTIPRHGGTIRLNGHHSKIIVTDFNFGSETLLYSTAEVLTYAVFDRKPTLVLWVPTGESGEFAIKGAKSGSVAKCSGCSNIKFHRDSGSLTVAFTQGEGISVLQLDNGVRVVLLDRQKAYTFWAPALTDNPLVPEGESVLVSGPYLVRTARLARSTLTLRGDSKGETLEIFAPRKIKKVTWNGKAVEATRTSYGSLKAILAKPPSVELPTLNGWKYSDSLPERFPTYDDSGAAWVEIDANHMTTPNPNKPATLPVLYADEYGFHNGVRLWRGYFNSSASGVYLNIQGGAAFGWSAWLNGHFLGSHLGSASIQQANGTLDFPANTLNTEGTPNVLLVVHDDTGHDQTTGVLNPRGILEARLLSEASDNNDDDSPGFTHWRVAGTAGGESDLDPVRGVYNEDGLYAERVGWHLPGFDDSKWATVNGTSLSFTGATVRFFRTVIPPLSIPENTDVSISFVFSTPNVNNTSAGNTSAFRAQLFVNGYQYGRYNPYVGNQVVYPVPPGILDYNGENTIGVAVWAQTEAGARLNLDWRVNYVLGSSLDAGRLDLSFVAIAYVYIFECLQL
The following text describes a protein:
Function:
Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity (By similarity). In vitro uses also acyl-CoA donors of different lengths from short-chain (C2) to long-chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl-CoA (C14) and palmitoyl-CoA (C16) that are not efficient (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDWLQFFFLHPVSLYQGAAFPFALLFNYLCITESFPTRARYLFLLAGGGVLALAAMGPYALLIFIPALCAVAMISSLSPQEVHGLTFFFQMGWQTLCHLGLHYKEYYLCEPPPVRFYITLSSLMLLTQRVTSLSLDISEGKVEAAWRGTRSRSSLCEHLWDALPYISYLLFFPALLGGSLCSFQRFQACVQRPRSLYPSISFWALTWRGLQILGLECLKVALRRVVSAGAGLDDCQRLECIYIMWSTAGLFKLTYYSHWILDDSLLHAAGFGSEAGQRPGEERYVPDVDIWTLETTHRISLFARQWNRSTAQWLKRLVFQRSRRWPVLQTFAFSAWWHGLHPGQVFGFLCWSVMVKADYLIHTFANGCIRSWPLRLLYRSLTWAHTQIIIAYVMLAVEGRSFSSLCRLCCSYNSIFPVTYCLLLFLLARRKHKCN
The following text describes a protein:
Function:
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAYFMTDVTKENRQDECRFSPNKEATEEDLLRIGVECTKVNFDDEHVQEDLDRLIKKYDMNFHDEVHICRATMPNFDEKLDIFFEEHLHDDAELRVIKHGVGFFDVRTKDEAWIRIPVRRGDFVFLPAGIYHRFTTDPSEDVVALRLFRNNPKWTAFNRKADGDEQRVRQQYLNDISA
The following text describes a protein:
Function:
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.
Subcellular Localization:
Cytoplasm. Cytoplasm, P-body.
Sequence:
MSDEEFFREIRETMIDDTRKMLENAGSSSGRKGLAKDSSKSTTTSTTPRKVESASNGETESGTAKAVLNEPLNALDGKSKHVKSSSTSAHLPHTRPEKTSDRSGKKREPKWNLAEMNQGSEMGDTNTTTTANAESTDKATMELVTLQLEPSGERKKLPVAAPNNAAVSSDAAESDDDDSPPPVGVPEEATDKDRTKARKLKKEMKRKVKEATKLQELNKKKQGKDGPGKDQLSQLTRQIQSIQAQIENLKKAARLDNAVGAGRPDRTRENPLKATRSVSESSSRKETKRKDKPQPATSTSNAFTNVAVIGGDELPPEHRLLVQLFMLSSNQRKKFLERQGMELGLLTPHPHKKHVVLVNKDIQHVAEGLATQARQYLAECREAALPAAPAKQHKDSSLQGATANSSHDSSNFKPKRYSRGTYEEQVTYLLNDGNVRSEEDYDPRLILLDIRDKAKEIIQERLDTFVQGLVTLNVGYVIEGFVRINARNNMQSFVDDASQVGNVYINSILLRRCAMEGDRVRVFVMPKAPSDDSATSPNANGNDESAEEDATQQAGGKSTQNSVGFVVAILEKRHNRQCVGKFLAAAPGKKHYRVFMPRDMRIPPVRVFKQDWPNALLSTNIAKLKDDKEEKEDRKVPQTGDVDVTDVLYQAEIIEWQDEVPIGTILKSIGKCGVLEVENESILVEHNLDVTPYGEAILAQLPAVPYCIPQEELERREDLRGECIFTIDPATARDLDDALSCKQLENGNYQIGVHISDVTYFLRESSPLDELVKLRATSIYMVDTVYHMLPKQLCNTCSLLPGEDKLAFSVFWEMQPDGTVLSTRFARTVINSCSQLSYEHAQLMLDNPSCEVEEDQFPEIMHGYNAKQLCKIVNTLQSIAVQLRQRRMDDGCLKINQPKLTFRLDPATGRPIEYGVYKVRPSNEMIEDFMLLANTSVANAIYKAFPEISLLRAHSPPAENMMKNLVRTLSLHGHALSYASPKDIRECMETIITTSENPDATRSVLSVLLAKPMIRAQYYCSLYATTPEHFMHYALAIPMYTHFTSPIRRYADCLVHRVLAAALAIDVQPKRSPEELQCLAMICNEKKYNAKCAGEASSLLYFRHWLEAVGEYETEAAVMGYAAHHIELVLIHSGIVLKAATKKLSTVATVVYKPTEPVASCMLIPNDTSIPPVELTIFTKVRVTVKVIKDTIIVSSVLPIATQEQSASQTVAQTVEQSVTDLSEEMKSARIY
The following text describes a protein:
Function:
Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.
Miscellaneous:
MISCELLANEOUS: According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MRMSFGLTFRTAKGHWLVNLSRQCSHGSTGLFVPPSPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFIRSAPIRQRYWARNFVGWPQFSSHQPNPAHLALSNWERLGKLYWLVTQNVDALHTKAGSQRLTELHGCMHRVLCLHCGEQTPRGVLQERFEVLNPTWSAEAHGLAPDGDVFLTEEEVQNFQVPSCARCGGPLKPDVVFFGDTVSADKVDFVHRRVKEADSLLVVGSSLQVSDLVAGGNCPFWGIGSPGEAPLLVSLFMHLESSYLALLLVQVYSGYKFILTAWEKKLPIAILNIGPTRSDGLACLKLDSRCGELLPLIDPH
The following text describes a protein:
Function:
Synthesis and degradation of fructose 2,6-bisphosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRRNSIAVEQAINPNMLRAANRSSEALLDNEKFGGVQPYSTESGMLFHAGKLVIIMSGLPARGKSNIAVSIDRYLRWLGFNCRFYSLAKYIDERTREMTSSPVKSAASENHVFSRNDTIERCLADLEIFLLKEKGQVAIYDATNGTRRTRRILYDRFKNCGFKILFIESLCNKEDVINANIQEAIHVSEEFRNWDLEMAEKEYCRRIDILKCHYETIDEKDYSFVKMINFAETIIANKSNEGYLLSRILFLLMNMTLARKRIFLVPKASMRPLKLREPEDDIENRQFSEYVADRIRKSFPDVSFKNLHVLSCMEDSVMSPFRELGSVTSSMSSLSPILMDSFGDDLQKLKETYGEEEYNLYLVDPYRYRVKRKESFYDLAVRLEPLILELGREQRDVLLIGSKSIIRVFYGYYMNVPAKDIPQLCLSSSSIYELIESSTGMTVNEYDL
The following text describes a protein:
Function:
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Also plays a role in the differentiation of both thymic and peripheral NKT cells. Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation. Positively regulates granzyme B production in NKT cells after innate stimulation. Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions; [Isoform 1]: Lacks transcriptional repressor activity. Binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Unable to regulate interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T-cells; [Isoform 2]: Transcriptional repressor that binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Regulates interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T cells.
Subcellular Localization:
Nucleus.
Domain:
The C2H2-type zinc finger are necessary for DNA-binding.
Sequence:
MKEESAAQLGCCHRPMALGGTGGSLSPSLDFQLFRGDQVFSACRPLPDMVDAHGPSCASWLCPLPLAPGRSALLACLQDLDLNLCTPQPAPLGTDLQGLQEDALSMKHEPPGLQASSTDDKKFTVKYPQNKDKLGKQPERAGEGAPCPAFSSHNSSSPPPLQNRKSPSPLAFCPCPPVNSISKELPFLLHAFYPGYPLLLPPPHLFTYGALPSDQCPHLLMLPQDPSYPTMAMPSLLMMVNELGHPSARWETLLPYPGAFQASGQALPSQARNPGAGAAPTDSPGLERGGMASPAKRVPLSSQTGTAALPYPLKKKNGKILYECNICGKSFGQLSNLKVHLRVHSGERPFQCALCQKSFTQLAHLQKHHLVHTGERPHKCSIPWVPGRNHWKSFQAWREREVCHKRFSSSSNLKTHLRLHSGARPFQCSVCRSRFTQHIHLKLHHRLHAPQPCGLVHTQLPLASLACLAQWHQGALDLMAVASEKHMGYDIDEVKVSSTSQGKARAVSLSSAGTPLVMGQDQNN
The following text describes a protein:
Function:
Cysteine protease responsible for the cleavage of kiwellin into kissper and KiTH.
Sequence:
MAIHLSALTISILVMVVSSAAVTSAAAEDMSIISYNEKHHTIGAGRTDDEVMSMYESWLVEHKKVYNALGEKDKRFQIFKDNLKYIDEHNAMPEKSYKLGLTKFADLTNEEYRSVYLGTKPDASRRLSSRQSDRYAPKVGDRLPESVDWVKKGVLVGVKDQGQCGSCWAFSAVAAIEAVNKIKTGDSISLSEQELVDCDTSSNNGCDGGLMDYAFEFVIKNGGLDTEEDYPYTGEDGRCDLTRKNAKVVTIDGYEDVPANDENAMKKAIASQPVSVAIEAGGKDFQHYKSGIFTGKCGAAVDHGVVAVGYGSENGMDYWIVRNSWGASWGEHGYLRMQRNIANPKGLCGIATVVSYPVKTGQNPPKPAPSPPSPVKPPTTCDDMYSCPSGTTCCCVYEYYHMCFAWGCCPMEGATCCKDHNSCCPHDYPVCNVKAGTCSISENNPLSVKAMSHILAKPIGSFSNQGMKNTIS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MALSHSMPRFGFLLIGLMTCTVVAIENNYKARGPLLVVGSINVDTTVHLDELPRRSETKIAQRPSPTLAVGGKGANQAVAAALLSAGTGRAAARFVCRLGDDAYLGWLQGELARAGLDTSASVVVPGMSTGAGIVWLDAEGAATSVVLGGANTQGWSLLPPDDASSAGEKAEEETAAREAALLAEHAAAVVAGGSGNASASSTGDTSAAALRASVLLLQREVPEHVNAAFAAAAAAAGIPVLLDAGGENKPVFAALLSHVDFLAPNEQELQRLTGLPTATEEQVAAAAGALMAAGARGVLVTLEGRGSLLLLGDVEAEAEAGKAAKGTGGISGGRRCRPVRAIRQPALPVPGGVVLDATAAGDAFRAALAVALVEGQGLEDGQGGKEGTGWEQALRFAAAAGAIAVSRMGAMPSLPTRAEVEQLLVEHGASPAAQAWDAPELLAAAARAAAAGSSGTEAAGASAAAAAGSCSLGGGGVGVQEGTCSNPASAAEAGTATTTIPVAATPESAAIGSCAASSSAATPQHHQPQLYQHDGADEAADGACPLLFGARLNSMKSRRDKLLANYANYLPAARSSEDGAAAGSQSAASGDAGQDGSAAAAARRERLLEQLKDNGPLGWVARQGLVRAADGWSGGQQQQQPAGGAGGGAWGGAGGLDVVYFNYPEHLKGLTLQQVQEALSLAGLAAGGVAMRFPADPFRAGAFTNPDPAVRAAAVALAVEGCGWAAQLAATAVAAGNLSASAAAAATPAPGHLVVWSAYDGYDYHLQADYGAAWSAAVEAYRQLADACAAMHVAVSIEPKPTDPSSRFSFLPNTASALSLVSAVGRPNLGLTLDTGHLLMAGECLAQSVAEVAAAGRLFGLHLNDGHGRLGAEDGLVFGSVHGAAALELMYYLRYKLPPRPAGAFSRGDGAAGVFGLPHAIFDTFPLNEDPVLEAEANVRAARGMWARAGRLRRAGLEGCLAAHDGLCGMRLMAELP
The following text describes a protein:
Function:
Component of the caffeine dehydrogenase complex that catalyzes the hydrolytical oxidation of 1,3,7-trimethylxanthine (caffeine) by incorporation of an oxygen atom originating from a water molecule into position C-8 to produce 1,3,7-trimethyluric acid (TMU). Coenzyme Q0 (ubiquinone-0) is the preferred electron acceptor and, to a lesser extent, coenzyme Q2 (ubiquinone-2) can also be used, but oxygen and NAD(P)(+) cannot. Is involved in a caffeine degradation pathway that allows Pseudomonas sp. strain CBB1 to grow on caffeine as the sole carbon and nitrogen source. Is also active with theobromine as substrate, but shows a very poor activity with theophylline and is not active with xanthine, 3-methylxanthine, 7-methylxanthine, TMU, and 3,7-dimethylurate.
Sequence:
MKPTAFDYIRPTSLPEALAILAEHSDDVAILAGGQSLMPLLNFRMSRPALVLDINDISELQQVRCENDTLYVGSMVRHCRVEQEEIFRSTIPLMSEAMTSVAHIQIKTRGTLGGNLCNAHPASEMPAVITALGASMVCKSEKRGERVLTPEEFFEGALQNGLQSDELLCEIRIPVPSQYVGWAFEEVARRHGDFAQCGAAVLIGAEDRKIDYARIALCSIGETPIRFHALEQWLIGRPVGNDLPADVKLHCREILDVAEDSTMTAENRAKLASAVTSRAIARAADRIVHLDVKRG
The following text describes a protein:
Function:
Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Also methylates 'Lys-5' of histone H4. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M.
Sequence:
MEALKVEKFTTANRGNGLRAVAPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRIAKYCSAKCQKKAWPDHRRECSCLKSCKPRYPPDSVRLLGRVIVKLMDEKPSESEKLYSFYDLESNISKLTEDKKEGLRQLAMTFQHFMREEIQDASQLPPSFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSMSLLNHSCDPNCSIVFNGPHLLLRAVREIEAGEELTICYLDMLMTSEERRKQLRDQYCFECDCIRCQTQDKDADMLTGDEQIWKEVQESLKKIEELKAHWKWEQVLALCQAIINSNSNRLPDINIYQLKVLDCAMDACINLGMLEEALFYAMRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMKVTHGREHSLIEDLILLLEECDANIRAS
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MECFSKVIVLYQILALQWFSPKRYRTFDCESLFFITLNFCIITGLFCWIYQHQSLVIYSDNALGYVVDFLKFLLMVFTYYSLFLESGYQRGVLYKVWDELERLHNIFPSAKWALQPQAHLRTVALFVVYMSWWELTYAYWITKSARSSNFTILFWVLFLLLHLRQLQILLYTNVLGFCLKAINSELAWTIELSNGASRYGGRRSDGQICGYLRKLMEGFARVERLLELLNQAFGYSLAIIKLINNIYILTDTYWIVHGFMSGKVFDSVYLECCLSSKFICLMINLHSNERILSEFHRTRVLLHCIHLRWQLRCDQGWQMVQHFLLKLESTQPFTMTALSMYRLDYGTLMQIAFNVTTSISLFIQASQ
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MGKKPCSRSAQPSKNPVGALPVSDSESEEPIHDTDFDEEEEILREKPKEEKVKVNRKREEGNVMEVMGKEKKEEGKLKNGKGGGGILTSKLFSELDISELTAKAIREMSYTHLTEIQARSIPHLMAQSDVMGVAKTGSGKTLAFLIPAIELLHSSHFLKENGTGVIVICPTRELAIQTHNVAKDLMKYHSQTLGYVIGGNNNMKSEANQLAKGINVLVATPGRLLDHLRSTSSFNYKKLKCLIIDEADRILEKNFEEDMKQIFKRLPRDRQTVLFSATQTQKPTVEGLQQGYCVIPSEKRFLVLYAFLRMIVRQGQKGLKEQKVMVFFSSCSSVKFHAELLNFLGVQCDDIHGQLKQQKRTSTFFRFSNEEKGILLCTNVAARGLDIPDVDYIHRVGRTARGDKGKGSALMFLLPEELKLLIHLQAANISLTEYDFSEKHVPKLQPKLEHIVGGNDFLNESAKQAYRSYLLAYNSHSLKGIFDIHQFDLKKVAASFGLKDPPKVSLNLESSASKHRKMRKLDGRRRQRIGPSNPYGRRGGYDLKWLLARF
The following text describes a protein:
Function:
Vacuolar Fe(2+) uptake transporter.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MEIVKSIVYGGLIESITSLVVVFSAAASDADTLKILIIGVANLIGGLFVICQNLMDLKIKYTRVGSNLSDQIDRYQELLGPKEHFLLHAIVALLSYFIFGLVPPLVYGFTYLKSDNKECKLIAVAIASSMCIIMLATAKAYTRGANKFSKYVKTVLFYGIAASMASGVGYAAGHFIKSLMDKLVGLTQSQLPLFLSPR
The following text describes a protein:
Function:
A reversible dehydrogenase involved in cholesterol side-chain degradation. Catalyzes the oxidation of hydroxyl-cholesterol-CoA ester metabolic intermediate (22S)-HOCO-CoA (3-oxo-chol-4-ene-(22S)-hydroxy-24-oyl-CoA), the product of ChsH3, has no activity on (22R)-HOCO-CoA (the product of EchA19). Also acts on (3R)-hydroxyoctanoyl-CoA and 17-beta-hydroxyandrost-4-en-3-one, but not on 7-alpha-hydroxyandrost-4-en-3-one, uses NAD(+) but not NADP(+).
Domain:
The protein surface forms a large groove around the active sites which is larger than homologs, probably to accommodate bulky sterol substrates.
Sequence:
MKLTESNRSPRTTNTTDLSGKVAVVTGAAAGLGRAEALGLARLGATVVVNDVASALDASDVVDEIGAAAADAGAKAVAVAGDISQRATADELLASAVGLGGLDIVVNNAGITRDRMLFNMSDEEWDAVIAVHLRGHFLLTRNAAAYWRDKAKDAEGGSVFGRLVNTSSEAGLVGPVGQANYAAAKAGITALTLSAARALGRYGVCANVICPRARTAMTADVFGAAPDVEAGQIDPLSPQHVVSLVQFLASPAAAEVNGQVFIVYGPQVTLVSPPHMERRFSADGTSWDPTELTATLRDYFAGRDPEQSFSATDLMRQ
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIFKYIQEPVLGSLFRSRDSLIYLNRSIDQMGWRLPPRTKPYWWLYYIWTLVVIVLVFIFIPYGLIMTGIKEFKNFTTTDLFTYVQVPVNTNASIMKGIIVLFMRRRFSRAQKMMDAMDIRCTKMEEKVQVHRAAALCNRVVVIYHCIYFGYLSMALTGALVIGKTPFCLYNPLVNPDDHFYLATAIESVTMAGIILANLILDVYPIIYVVVLRIHMELLSERIKTLRTDVEKGDDQHYAELVECVKDHKLIVEYGNTLRPMISATMFIQLLSVGLLLGLAAVSMQFYNTVMERVVSGVYTIAILSQTFPFCYVCEQLSSDCESLTNTLFHSKWIGAERRYRTTMLYFIHNVQQSILFTAGGIFPICLNTNIKMAKFAFSVVTIVNEMDLAEKLRRE
The following text describes a protein:
Function:
Transferrin receptor subunit involved in receptor-mediated acquisition of iron from the environment by binding host TF/transferrin.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Flagellar pocket. Note=Upon host TF/transferrin binding, the complex formed by ESAG6-ESAG7-TF is endocytosed and delivered to the lysosome where iron is released and host TF is degraded. ESAG6-ESAG7 are then recycled back to the flagellar pocket membrane. May also be secreted.
Sequence:
MRFWFVLLALLGKEIYAYENERNALNATAANKVCGLSTYLKGIAHRVNSESAVVTEKLSDLKMRSIQLQLSVMRNRVPSGEQDCKDIRTLLKTVLRNEFTFQQELEEMRNASALAAAAAGLAAGRLEEWIFVFAQAAGRSSQFCISVGKTGPAEYNNLQECFDGTIGPETLYKIEDSRVKESAKTSLQLHEVLSSISFGSLGVKNIRGGNGKDGCNLVRTDTDGVLEGGSPTRHNLTWGGGVMNFGSYQNGSMYVEGGEYGDATEYGAVRWTEDPSKVSIFKDVIRLFARFQEAKNAVVKKIKTTVDELTKCIGQKEAELTNDQLYEEFIWETINRLELSKRVSEQSAFGEEEETIVKFNYTAEPVRGPFTVAGANAAAIHLSVSTAALCRSALLLGVL
The following text describes a protein:
Function:
Catalyzes the release of fatty acids from lysophospholipids.
Subcellular Localization:
Secreted.
Sequence:
MHLPSSLLIAAPLLANVSAEPIRIPQRDVSVVSTSQQLAVRALPDSPSGGYAPAVVDCPKTKPTLRKAVDLSNEEKNWLSIRRKNTIQPMRDLLKRANITGFDSETFMNEAANNISQLPNVAIAISGGGYRALMNGAGFVAAADNRIQNTTGAGGIGGLLQSSTYLAGLSGGGWLVGSLFSNNFSSIETLLSENKVWDFENSIFKGPKEAGLSTVNRIQYWSEVAKEVAKKKDAGFETSITDYWGRALSYQLIGADMGGPAYTFSSIAQTDNFQKAETPFPILVADGRAPGDTIISLNATNYEFNPFETGSWDPTVYGFAPTKYLGANFSNGVIPSGGKCVEGLDQAGFVMGTSSTLFNQFLLANISSYDGVPDVLIEAVTSVLKEIGAKRDDVSQIIPNPFLDWNNRTNPNADTLELDLVDGGEDLQNIPLNPLTQPVRAVDVIFAVDSSADVTNWPNGTALRATYERTFGSISNGTLFPSIPDDWTFINLGLNNRPSFFGCDVKNFTLNANQKVPPLIVYVPNAPYTALSNVSTFDPSYTMSQRNDIIGNGWNSATQGNGTLDSEWPTCVACAVISRSLDRLGRQTPAACKTCFERYCWNGTVNSKDTGVYMPEFKIADAHALDSGAVAIGKMVNVWSSVVVGVVAATLLL
The following text describes a protein:
Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.
Domain:
A region including the PH domain and partially overlapping with the Rho-GAP domain mediates interaction with phosphoinositides.
Sequence:
MLSSRWWPSSWGILGLGPRSPPRGSQLCALYAFTYTGADGQQVSLAEGDRFLLLRKTNSDWWLARRLEAPSTSRPIFVPAAYMIEESIPSQSPTTVIPGQLLWTPGPKLFHGSLEELSQALPSRAQASSEQPPPLPRKMCRSVSTDNLSPSLLKPFQEGPSGRSLSQEDLPSEASASTAGPQPLMSEPPVYCNLVDLRRCPRSPPPGPACPLLQRLDAWEQHLDPNSGRCFYINSLTGCKSWKPPRRSRSETNPGSMEGTQTLKRNNDVLQPQAKGFRSDTGTPEPLDPQGSLSLSQRTSQLDPPALQAPRPLPQLLDDPHEVEKSGLLNMTKIAQGGRKLRKNWGPSWVVLTGNSLVFYREPPPTAPSSGWGPAGSRPESSVDLRGAALAHGRHLSSRRNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLVRWVEARREAPTGRDQGSGDRENPLELRLSGSGPAELSAGEDEEEESELVSKPLLRLSSRRSSIRGPEGTEQNRVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQLVQLMLTNFTSLFP
The following text describes a protein:
Function:
Might play a role in the regulation of methionine metabolism possibly by binding and inactivating Ahcy.
Sequence:
MNNLADTVVVDPGFGGGDKQQQAGPAPQDASVVVPPPATKQSSALKKTSRYRSRSLSASSTDSFSSASYTGSSEDGDDVPPREKVQKNSKGSSDFCVRNIGAQHAFGRREIEIAEQEMPGIIALKKRAAEDKPLKDAKIVGCTHINAQTAVLIETLVELGASVRWAACNIYSTQNEVAAALAESGIPIFAWRGETEEDFWWCIDRCVNAENWQPNMILDDGGDATHLMLKKYPTMFKLVKGIVEESVTGVHRLYQLSKAGKLTVPAMNVNDSVTKTKFDNLYSCKESILDSLKRSTDVMFGGKQVVVCGYGDVGKGCAQALKGQGCIVYITEIDPICALQASMDGFRVVKLNEVIRNVDIVVTATGNKNVVVREHMDKMKSGCIVCNMGHSNTEIDVNGLRTPDLTWEKVRSQVDHIIWPEGKYIILLAEGRLVNLSCSSIPSFAVSITSATQALALIELFNAPPGRYKSDVYLLPKKMDEYVASLHLPTFDAHLTELSDEQAKYMGLNKAGPFKPNYYRY
The following text describes a protein:
Function:
Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1.
Miscellaneous:
MISCELLANEOUS: Present with 3670 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm.
Sequence:
MDEILAKAGSQAVTFAIKSGISIASTYALKTITNFVVQIPKDDARRIDQLKFKLESRMAIVSSAIDLIKLVAARGNTNLQITLRLTKDLKEEIDRFDEKINEMTQKVEGSRSAKTQNEAIKAVENYIKDLLLRIEEITPFINLSLTTSGANLNSALPYQLSPGLLLKASDFVSENNRKYEKAMKSNEKGTGDKEILKVQVGPTFEVTLFSIFYNLTSENNGQSGIVWKEDMKRAKARIYRLNSTGRKYDYFMKIEQDFNDGRYHEDDDKEDTPQELAIDLNHIKKLFFSVSGKLLRLEEQDSPVLVLKIDRSDDKENESSEGDKGLLDDITWYAVSGYEAIEEDEEEDEEEDEEEGKDGEERKEEEEEENKLEDKDSSITLLEYIIRLTSLQSNDQKSILEVSDERLSIYLNDENTNSRKDRISNSTIEETEKKLKNLKL
The following text describes a protein:
Function:
Required to stabilize the cell wall in the absence of multiple GPI-anchored mannoproteins.
Subcellular Localization:
Secreted, cell wall. Cell surface.
Sequence:
MLQSVVFFALLTFASSVSAIYSNNTVSTTTTLAPSYSLVPQETTISYADDTTTFFVTSTVYSTSWFTSTSATITNAASSSLSTSSASGSVTPESTHEITSTSTITSTLLLTLHDSTTLSPSSTAASVSDEDSNNKDAKVKSFEQASTSNGCVPITKFVTVTNEPVTQYVTVTPNTTTQYVTVTGAPSVTTTSPGNVQWYNTTSITNSTSW