lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLLPWLILIPFIGGFLCWQTERFGVKVPRWIALITMGLTLALSLQLWLQGGYSLTQSAGIPQWQSEFDMPWIPRFGISIHLAIDGLSLLMVVLTGLLGVLAVLCSWKEIEKYQGFFHLNLMWILGGVIGVFLAIDMFLFFFFWEMMLVPMYFLIALWGHKASDGKTRITAATKFFIYTQASGLVMLIAILALVFVHYNATGVWTFNYEELLNTPMSSGVEYLLMLGFFIAFAVKMPVVPLHGWLPDAHSQAPTAGSVDLAGILLKTAAYGLLRFSLPLFPNASAEFAPIAMWLGVIGIFYGAWMAFAQTDIKRLIAYTSVSHMGFVLIAIYTGSQLAYQGAVIQMIAHGLSAAGLFILCGQLYERIHTRDMRMMGGLWSKMKWLPALSLFFAVATLGMPGTGNFVGEFMILFGSFQVVPVITVISTFGLVFASVYSLAMLHRAYFGKAKSQIASQELPGMSLRELFMILLLVVLLVLLGFYPQPILDTSHSAIGNIQQWFVNSVTTTRP
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification (By similarity).
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MAHVRTFTLPHYEAYPVHVALFKDVKNPSYLKSQLLEANPAFDYAFLDAAMVARLGIAWWSHAAANDRPQILSPTHLLSTTFITIHALCTHRQKTRTPHSELVFRLSPNNNIGESYKKFGISDTTTHLIAVKLPLKSSDAEAKEWLVDGEITNESVSQHLGSVVEGTSVEISEKGEELGQWCDIDKIRKVYKLGDGSAKKGKKGAAVNGDGAEKEGEKKQMEVVILGTIALKS
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MASDQIMHAQPEFLATDETNNYMYDQLWKLCAGHLFDLPKIGEELVTYINDELCQLKPVFNIPSKIRCNVFSIKLKAETTTDEIYAEISLLPDTSEVEIPIPKCENHIQNIKCFTKVLSASDTSKKGGFVLNKRHAIECLPPLDTSHLTQSQEINATDIHGHEWKFKHALKGTPQRHLFTSGWNEFAKAKKLVVGDSFVFFREENGESRVGIRKAAHHQQENIPSSVISTESMHHGVVATALNAIKRKCMFVVFYKLGSSQFVVNIDKFIDGVNKKFGIGSRFLMKFEGKDFNEIRYYGSILKVRDFSTNWKDSEWRCLEVQWDEAATIPRPDKVSPWEIEPLTHSSDILKSGSNMWVPTLTQGQEVGHSSIQSSMSYSFPTTMSKPNYNEQMVQVMKETSTTTATTSYRLFGVDLKIPAVTKDSIEPINSYKKSKISKFFDEEKVDHNQTRSHTKVRMEGSVERTVDLSVFDGYNQLTDELERLFDIKGKLHMHNQWKIVFINADGDMMLLGDDPWLKFCNTAKEIFICSKNDAKIGDADNKFSKGHPTLRTTILPPDVNNN
The following text describes a protein:
Function:
Involved in the metabolism of insect hormones; responsible for ecdysteroid C25-hydroxylase activity. May be involved in the breakdown of synthetic insecticides.
Miscellaneous:
MISCELLANEOUS: Member of the Halloween gene group.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MSADIVDIGHTGWMPSVQSLSILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFELKMGRVPTVVLSDAALVRDFFRRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSGVVNFLPWLRHLPANVRNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQRRLHELLLPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRILRRFHLELPSGTEVDMAGESGITLTPTPHMLRFTKLPAVEMRHAPDGAVVQD
The following text describes a protein:
Function:
Involved in rRNA-processing and ribosome biosynthesis.
Miscellaneous:
MISCELLANEOUS: Present with 3060 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVESNDIIKSGLAEKALKALILQCEENPSLKNDKDIHIIINTGKKMGINRDNIPRIIPLTKYKLFKPRDLNILLITKDPSALYRETLTKDEHTSELFKEIISVKNLRRRFKGSKLTQLYKDFDLVVADYRVHHLLPEVLGSRFYHGSKKLPYMIRMSKEVKLKRQQMVEKCDPIYVRAQLRSICKNTSYIPNNDNCLSVRVGYIQKHSIPEILQNIQDTINFLTDKSKRPQGGVIKGGIISIFVKTSNSTSLPIYQFSEARENQKNEDLSDIKL
The following text describes a protein:
Function:
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
Sequence:
MVDTQYAFRAQKTAGVADAPAWEVSNRIPAETVGSKCYAYSPNGEWLAYAMNNCVEIIPSHSSSPTPVTLQQANIVALKFSPMSSYLFTFERPVKTESGEMYKNAKAWDVKNGEIVGGWYQKTMEDWEPIITPNETHLLRAGPSDLAIFSPPFAPRPSTRLKIEGIRGIFISDPSALPATSTNSRPIPAYHEPAVAIWIGEKKGAPASLGLWSLSSLMGKNALQANGNGDIQTETRDMPPTTARKAFYKADKLTVKWNNAGTMALFLAQSDVDNSGKSYYGETNLYLVGLDGTFDGLVELDKEGPIYDFAWSPISREFTVCYGYMPARTQMFDLKAKPVYSFGENPRNTLVYQPQGKLLLSAGFGNLAGGIDIWDVSTRNKVAEFKASNASHCEWSPCGRYVLTATLSPRLRVDNGVKIWWCNGQLLHIQPVEELYQASFAPQRVTEIGSFPAIVPKAPEANPSVAAYRPKGETDGVAAKPAGAYRPPGARNRPEGENASASFGSSRGKPGVRTVPGAGGRQPPGSAPGASTGAGGDDKKKRQRKRGGKDKEEEKKDEAPTQEAVKPEVKEEAGEDAVAKKIRNLMKKLKAIDELKTKLAAGEILEKTQLKKIESEAQVKSEIKALGGNV
The following text describes a protein:
Function:
Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Subcellular Localization:
Secreted.
Sequence:
KRCSNLSTCVLGKLSQELHKLQTYPRTNTGSGTPGKKRSLPESNRYASYGDSYDGI
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MASTSPPSTSSPAAMSSTTTTATTATAKPCIKCRSNPGTLDSRGQLVCHICFQKFISQKCIKQIGLLNKDVRSSSSQSLSAYHLSQKNSGPPQASSRRYLLGLSLGASSAALLELLNENVEFQLSKGRNAPFELEVVHVSCAAGAGADGGGGGGGLEDDGKGRTTTEREKVEEVVLKRLGGRYPRFEFRVVYLEEVVGLETVDWEGLGLEDFAGSSSTSTTTKAEKLQQLFDNLPSTTSRTDLLRLFTRHLLIAEARKSHCHALLLGSSTTALAELTLSETAKGRGFSLPWQINDGVLGVPSFSPSSSPSPPSSPADAGKKTKMEETGMLVYHPLRDALRKELVTFTKLAGQPTPIAELLPETDSFTTTAAVVSHKDLSIDEVMVRYFAEVEENYPSIVANVARTTGKLMRLFGGAGVADGDGDEEGGGKAVGEDGSEDNDEERLCGLCSMPLDVLGDERWKGELGEDSYRDALVVDKGAKRMKQRICYGCERSIRG
The following text describes a protein:
Function:
Seed storage protein. Accumulates during seed development and is hydrolyzed after germination to provide a carbon and nitrogen source for the developing seedling.
Subcellular Localization:
Vacuole, aleurone grain. Endoplasmic reticulum. Protein storage vacuole. Note=Localizes in protein storage vacuoles in cotyledons of developing and mature beans. Synthesized and assembled into trimers in the endoplasmic reticulum, and transported to the protein storage vacuoles by the dense vesicles.
Sequence:
MMRARFPLLLLGLVFLASVSVSFGIAYWEKENPKHNKCLQSCNSERDSYRNQACHARCNLLKVEKEECEEGEIPRPRPRPQHPEREPQQPGEKEEDEDEQPRPIPFPRPQPRQEEEHEQREEQEWPRKEEKRGEKGSEEEDEDEDEEQDERQFPFPRPPHQKEERKQEEDEDEEQQRESEESEDSELRRHKNKNPFLFGSNRFETLFKNQYGRIRVLQRFNQRSPQLQNLRDYRILEFNSKPNTLLLPNHADADYLIVILNGTAILSLVNNDDRDSYRLQSGDALRVPSGTTYYVVNPDNNENLRLITLAIPVNKPGRFESFFLSSTEAQQSYLQGFSRNILEASYDTKFEEINKVLFSREEGQQQGEQRLQESVIVEISKEQIRALSKRAKSSSRKTISSEDKPFNLRSRDPIYSNKLGKFFEITPEKNPQLRDLDIFLSIVDMNEGALLLPHFNSKAIVILVINEGDANIELVGLKEQQQEQQQEEQPLEVRKYRAELSEQDIFVIPAGYPVVVNATSNLNFFAIGINAENNQRNFLAGSQDNVISQIPSQVQELAFPGSAQAVEKLLKNQRESYFVDAQPKKKEEGNKGRKGPLSSILRAFY
The following text describes a protein:
Function:
Required for nuclear membrane fusion during karyogamy.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MLEILLFLCVIIQRSHINAEITHVVSHLAETALRQDTNFQLLSQDIIAKKFPILDSSCVRRALSDFLPQCLQYGFETVPSDVRTQAAVKLSICELQASGVDNMPPECVGAVHFGACLRAMERTPQWWTTYSGNYQHLPSTCFENALPYEKEQLLSLFLNITDVYSNFQDDLVVDLEKYRANFEATVEASLRLMKASLMEGTHEIVNQLKDDLNYVNSKLADMGETITEHTDNVRTVFNDISDELNDYDMAGQIAHLKEDTMSLWQKINSDMGTYHDVQMSSLYNINAVFDTFYNRATESVQQVRTSVIESQLETLDLIADFNSLVRKSILPVLADELQPQLQEMSVSISRSLVGLSASYNEHLQAWSNRVNETLSEMESHLNNTMSQVEHMNDSIETLENKVFVLVSLGNALTTYVKWIYTFSRALISGYGIVTLIMSMLVVRYSIKLNSSWIKVLGRSTFILVAVVLGARTGSMLSY
The following text describes a protein:
Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTEDSDSISEEERSLFRPFTRESLQAIEARIADEEAKQRELERKRAEGEIRYDDEDEDEGPQPDPTLEQGVPVPVRMQGSFPPELASTPLEDIDSFYSNQRTFVVISKGKDIFRFSATNALYVLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKEFPLDGSWGNLTDESWELFNSNDTNWFYSESGDIPLCGNSSGAGQCDEGYICLQGYGKNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQLVLRSAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEALREAEEAAAAKAAKLEAQQAAAAAAANPEIAKSPSDFSCHSYELFVGQEKGNDDNNKEKMSIRSEGLESVSEITRTTAPTATAAGTAKARKVSAGVATIQKASLSLPGSPFNLRRGSRGSHQFTIRNGRGRFVGVPGSDRKPLVLSTYLDAQEHLPYADDSNAVTPMSEENGAIIVPVYYANLGSRHSSYTSHQSRISYTSHGDLLGGMTKESRLRNRSARNTNHSIVPPPNANNLSYAETNHKGQRDFDLTQDCTDDAGKIKHNDNPFIEPAQTQTVVDMKDVMVLNDIIEQAAGRHSRASDHGVSVYYFPTEDDDEDGPTFKDKALEFLMKMIDIFCVWDCCWVWLKFQEWVAFIVFDPFVELFITLCIVVNTLFMALDHHDMDPDMEKALKSGNYFFTATFAIEATMKLIAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTVGALGNLTFVLCIIIFIFAVMGMQLFGKNYTDNVDRFPDHDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNETNKIAEAFNRISRFSNWIKMNLANALKFVKNKLTSQIASVQPTGKGVCPCISSEHGENELELTPDDILADGLLKKGIKEHNQLEVAIGDGMEFTIHGDLKNKAKKNKQIMNNSKVIGNSISNHQDNKLDHELNHRGVSLQDDDTASIKSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGIDEELDDEGEGDEGPLDGELIIHAEEDEVIEDSPADCCPDNCYKKFPVLAGDDDAPFWQGWGNLRLKTFQLIENKYFETAVITMILLSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFIIVMLSLINLAAIWVGAADIPAFRSMRTLRALRPLRAVSRWEGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDKNKTTLPHEIIPDVNACKAENYSWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRDVGKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTNKKFDMIIMLFIGFNMLTMTLDHYKQSETFSAVLDYLNMIFICIFSSECLMKIFALRYHYFIEPWNLFDFVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKSGLDDVYNFKTFGQSMILLFQMSTSAGWDGVLDGIINEEDCLPPDNDKGYPGNCGSSTIGITYLLAYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPDGTQYVRYDQLSDFLDVLEPPLQIHKPNRYKIISMDIPICRGDMMFCVDILDALTKDFFARKGNPIEETAELGEVQQRPDEVGYEPVSSTLWRQREEYCARLIQHAWKRYKQRHGGGTDASGDDLEIDACDNGCGGGNGNENDDSGDGATGSGDNGSQHGGGSISGGGGTPGGGKSKGIIGSTQANIGIVDSNISPKESPDSIGDPQGRQTAVLVESDGFVTKNGHRVVIHSRSPSITSRTADV
The following text describes a protein:
Function:
Guanine nucleotide exchange factor (GEF) that regulates the assembly of the coat protein complex II/COPII in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport. Selectively activates SAR1A and SAR1B by promoting the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) in these small GTPases. In their activated GTP-bound state, SAR1A and SAR1B insert into the membrane of the endoplasmic reticulum where they recruit the remainder of the coat protein complex II/COPII which is responsible for both the sorting of proteins and the deformation and budding of membranes into vesicles destined to the Golgi; Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus. Note=Concentrates at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).
Sequence:
MGRRRAPELYRAPFPLYALQVDPSTGLLIAAGGGGAAKTGIKNGVHFLQLEQINGRLSASLLHSHDTETRATMNLALAGNILAAGQDAHCQLLRFQTHQQKGKTKVEKAGSKEQGPRQRKGAAPVEKKPGAETHQEGIELSVENLKAVQTDFSPDPFQKVVCFNHDNTLLATGGTDGYVRIWKVPSLEKVLEFRAHEGEIEDLALGPDGKLVTVGWDLKASVWQKDQLVTQLHWQENGPTFSNTPYRYQACRFGHVPDQPTRLRLFTVQIPHKRLRQPPPCYLTAWDGSTFLPLRTKSCGHEVISCLSVSESGTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPELLGFHETALFSVAVDSRCQLHLLPSRRSVPVWLLLLLCVGLIVMTILLLQSVFPGFL
The following text describes a protein:
Function:
ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDEEEDSSNVDLPYIPAENSPTRQQFHSKPADSDSDDDPLEAFMAEAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDNLEYDSDGNPIAPSKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEPGDGPIAVIVCPTRELCQQIHAECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENTDRGNNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPIVSAAKGIPGFGNTGNLSSAPVTYPSTGVQGVNNTASGNNSREGIGGGNGKRERYTENRGGSRHSHGESGNRHGDSPRHGDGGRHGDGYRYPESGSRHADGHRHGENRHGGGGGRHGESRAANDGRNGESRKEGCNRESKMDPKVDSSKMDKMDSKTDKTADGFAVPEPPKRKKSRWDS
The following text describes a protein:
Function:
Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables (By similarity).
Domain:
IQ domain mediates interaction with calmodulin.
Sequence:
MAHKVKASFQSLKTMPADYRFLGSPISDHLETNLITPPNGHLKNGVNGTASSVGGMDSVNEDSPYSVRSILNGERSSIGDGDSILPLPESNDRKWSDTNVYARKKVLQFWVQLPNGNWELGKIMSTSGEESVIVVTEGKVLKVKSETLVPANPDILDGVDDLMQLSYLNEPAVLYNLEYRYNQDMIYTKAGPVLVAVNPFKEVPLYGNRNIEAYRKRSNESPHVYAIADTAIREMIRDEVNQSIIISGESGAGKTETAKIAMQYLAALGGGSGIEYEILKTNPILEAFGNAKTLRNDNSSRFGKLIEIHFSETGKISGAQIQTFLLEKSRVVQCTEGERSYHIFYQLCAGASPTLREKLNLTSAKQYNYLKQSNCYSINGVDDAERFHAVKEALDIVHVSKEDQENVFAMLAAVLWLGNVSFTIIDNENHVEPEPDESLSTVAKLIGCNINELKLALSKRNMRVNNDTIVQKLTLSQAIDARDALAKSIYACLFDWLVEQINKSLAVGKRRTGRSISILDIYGFESFNKNSFEQFCINYANERLQQHFNRHLFKLEQEEYIQDGIDWTRVDFEDNQECLSLFEKKPLGLLSLLDEESTFPNGTDLTLANKLKQHLNDNSCFRGDRGKAFTVAHYAGEVTYETTGFLEKNRDLLHSDSIQLLSSCSCHLPQAFASSMLIYSEKPLVGPLHKAGGADSQRLSVATKFKGQLFQLMQRLGNTTPHFIRCIKPNNVQSAGLYEQGLVLQQLRCCGVLEVVRISRSGFPTRMFHHKFARRYGFLLLENIAAKDPLSVSVAILHQFNILPEMYQVGYTKLFFRTGQIGVLEDTRNRTLHGILRLQSYFRGHQARCRLKELKTGITILQSFVRGEKMRKEYTELLQRHRASAAIQSHVKRRIASQQYKATVDASAVIQSAIRGELVRRCAGDIGWLSSGGTKRNESDEVLVKASYLSDLQRRVLRTEAALREKEEENDILRQRVQQYDNRWSEYETKMKSMEEIWQKQMKSLQSSLSIAKKSLEVEDSARNSDASVNASDATDLDSGGSHYQMGHGRSRSVGVGLSVISRLAEEFGQRAQVFGDDRKFLMEVKSGQVEANLNPDRELRRLKQMFETWKKDYGGRLRETKLILSKLGSEETGGSAEKVKMNWWGRLRSTRY
The following text describes a protein:
Function:
[Isoform Holin]: Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space. Determines the precise timing of host cell lysis. Participates with the endolysin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell; [Isoform Antiholin]: Counteracts the aggregation of the holin molecules and thus of pore formation.
Subcellular Localization:
Host cell inner membrane; Multi-pass membrane protein. Note=Classified as a class I holin.
Domain:
[Isoform Holin]: Has 3 transmembrane regions whereas isoform Antiholin lacks the first transmembrane region; The C-terminus acts as a cytoplasmic regulatory region.
Sequence:
MKMPEKHDLLAAILAAKEQGIGAILAFAMAYLRGRYNGGAFTKTVIDATMCAIIAWFIRDLLDFAGLSSNLAYITSVFIGYIGTDSIGSLIKRFAAKKAGVEDGRNQ
The following text describes a protein:
Function:
Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b).
Subcellular Localization:
Cell outer membrane; Lipid-anchor; Periplasmic side.
Sequence:
MTKMHRYAAIAALAIFLSGCMAQRQPAPVEEVKPAPEQPAQPPQPPVVPSVPTIPQQPGPIEHEDQTGQPAPKVRHYDWNGAMQPLVSKMLQADGVTAGSVLLVDSVNNRTNGSLNANEATETLRNALANNGKFTLVSVQQLSMAKQQLGLSPQDSLGTRSKAIGIARNVGAQYVLYSSASGNVNAPALQMQLMLVQTGEIIWSGKGAVQQQ
The following text describes a protein:
Function:
Involved in the immune response to bacterial infection.
Subcellular Localization:
Secreted.
Sequence:
MNKIFGLLFTLCLLLVWPTPGNGQSPDESRLLVAIHYEALCPDSMSFIRRRLYDALQDNDWWSVTDLKLYPFGKAGFYNNTSTGESQVFCQHGVDECELNALHACIIETLDIRKAFNLIYCMLRSYSNELGPCSRSMGVDVSKARECKASRTTAEILAPYGKETLKLGISFVPTIVFENDFDPYDQRSIRNNFERHFCRQYLKKFNIKLPTCSAIL
The following text describes a protein:
Function:
The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
Subcellular Localization:
Mitochondrion.
Sequence:
MFATLRRHVARGVGLQVRAKSGGQHNVLNRGQLPFLYNASGPTAVRYTDQHEWIAAHADGTAFVGVTKYAADALGDATYVELPAADAAVEVGEGLGSIESVKSASEVYAPAGGVVVEANEALQASPQLLNQDPMGAGWLCRLRLHDAAELDSDRLMTLERYEQSLREDA
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
Miscellaneous:
MISCELLANEOUS: Present with 4675 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MVEGDSYVETLDSMIELFKDYKPGSITLENITRLCQTLGLESFTEELSNELSRLSTASKIIVIDVDYNKKQDRIQDVKLVLASNFDNFDYFNQRDGEHEKSNILLNSLTKYPDLKAFHNNLKFLYLLDAYSHIESDSTSHNNGSSDKSLDSSNASFNNQGKLDLFKYFTELSHYIRQCFQDNCCDFKVRTNLNDKFGIYILTQGINGKEVPLAKIYLEENKSDSQYRFYEYIYSQETKSWINESAENFSNGISLVMEIVANAKESNYTDLIWFPEDFISPELIIDKVTCSSNSSSSPPIIDLFSNNNYNSRIQLMNDFTTKLINIKKFDISNDNLDLISEILKWVQWSRIVLQNVFKLVSTPSSNSNSSELEPDYQAPFSTSTKDKNSSTSNTEPIPRSNRHGSVVEASRRRRSSTNKSKRPSITEAMMLKEEGLQQFNLHEILSEPAIEEENGDSIKEHSTTMDGANDLGFTASVSNQENAGTDIVMEDHGVLQGTSQNYGTATADDADIEMKDVSSKPSKPESSVLQLIVSEDHIILDTISECNLYDDVKCWSKFIEKFQDIVS
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MHSCRSHAEHRICISIPKENTMDSTTSIAVASIIMAGLTTAIGSIGPAFAEGRAVAQALNSIAQQPDSSNTITRTLFVGLAMIESTAIYCFVVSMILLFANPFWNQLTQ
The following text describes a protein:
Function:
Involved in copper export. Could be involved in the copper detoxification of mycobacterial cells.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTTAVTGEHHASVQRIQLRISGMSCSACAHRVESTLNKLPGVRAAVNFGTRVATIDTSEAVDAAALCQAVRRAGYQADLCTDDGRSASDPDADHARQLLIRLAIAAVLFVPVADLSVMFGVVPATRFTGWQWVLSALALPVVTWAAWPFHRVAMRNARHHAASMETLISVGITAATIWSLYTVFGNHSPIERSGIWQALLGSDAIYFEVAAGVTVFVLVGRYFEARAKSQAGSALRALAALSAKEVAVLLPDGSEMVIPADELKEQQRFVVRPGQIVAADGLAVDGSAAVDMSAMTGEAKPTRVRPGGQVIGGTTVLDGRLIVEAAAVGADTQFAGMVRLVEQAQAQKADAQRLADRISSVFVPAVLVIAALTAAGWLIAGGQPDRAVSAALAVLVIACPCALGLATPTAMMVASGRGAQLGIFLKGYKSLEATRAVDTVVFDKTGTLTTGRLQVSAVTAAPGWEADQVLALAATVEAASEHSVALAIAAATTRRDAVTDFRAIPGRGVSGTVSGRAVRVGKPSWIGSSSCHPNMRAARRHAESLGETAVFVEVDGEPCGVIAVADAVKDSARDAVAALADRGLRTMLLTGDNPESAAAVATRVGIDEVIADILPEGKVDVIEQLRDRGHVVAMVGDGINDGPALARADLGMAIGRGTDVAIGAADIILVRDHLDVVPLALDLARATMRTVKLNMVWAFGYNIAAIPVAAAGLLNPLVAGAAMAFSSFFVVSNSLRLRKFGRYPLGCGTVGGPQMTAPSSA
The following text describes a protein:
Function:
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates. May contribute to amoebic pathogenicity and may be involved in the destruction of extracellular matrix components (Probable).
Subcellular Localization:
Cytoplasmic granule. Secreted.
Sequence:
MPYPSSVSFQWKSPLAIALTSSIQLNVKSTCNTDCMNFLKSNFNHTISFPLQQQTGLQDFKVSLFKEIDLPRITPSVSSVITDVVVELSSSNPMPKLQIGFDESYILEVTTNSISIKAVTVYGARHAFETLLQLIRISSNKFVISQLPIKISDAPRFKWRGLMVDPSRNPLSPLMFKRIIDTLASVKANVLHIHLSDAQTFVFESKKYPLLHQKGMYDESFVLTQSFLRELAQYGANRGVIVYGEIDTPAHTASWNLGYPGVVANCWDYIVSTSMRYGENVLSLNPANPNTFPIIDALMKELSDTFGTDYVHVGGDEVWTSGWSKSKEYSDIQKFMKSKGLNSLTELEGYFNKYAQEQVIHNGKHPVVWEEVFKKGNADKNTIIQVWDDIRLLQQVVNSGYKAIFSAGFYLDKQMPLCNSYDSSTCVNTHSMWVWTNRDMYDNDPVKSLSSSEKENVLGGEGCSWGESTDEQNFFDRVFQRYSAIAERLWSKESVVDKESHEVRANYLRCLDVRRDIMKGTGPLYHSFCQLPKKEKSN
The following text describes a protein:
Function:
High affinity permease for methionine.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSEGRTFLSQLNVFNKENYQFSSSTTKKEVSNSTVDADNGASDFEAGQQFATELDQGEKQLGILSCIGLICNRMLGTGVFAVSSTIYTLCGSVGLALIMWAVGAIIAISGLYVYMEFGTAIPKNGGEKNYLEAIFRKPKFFITCMYAAYIFFLGWAAGNSINTAIMFLTAADTEVTKWNQRGIGVAVVFFAFLINSLNVKIGLYLQNILGIFKIGIVLFISITGWVALGGGLKDGYQSHNFRNAFEGTETATAYGIVNALYSVIWSFVGYSNVNYALGEVKNPVRTLKIAGPTSMVFLAIIYIFVNIAYFAVVPKDKLISSKLILAADFFDIVFGGQAKRAAAALVGLSALGNVLSVIFSQGRIIQQLGREGVLPFSNFFASSKPFNSPMVGLFQHFIVCTVTILAPPPGDAYLLVQNLISYPMNIINFAISAGLLWIYWQRRQGKIEWNPPIKAGVFVTGFFTLSNLYLIIAPYVPPSNGESVYSSMPYWIHCVIAWGIFFFGGVYYVVWAQLLPRWGHYKLVSKDVLGEDGFWRVKIAKVYDDTIGDVDTQEDGVIETNIIEHYKSEQEKSL