lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNGGPSGFNNAPVTRAFVITSVLFTVFLGIRGGGGGSSSKLALSYQDVFEKFRIWKLIKSSFAFSSTSELLFGVYLLYYFRVFERQIGSNKHSVFILFSGFVSLILQTLVLSLFKDTTANLLTSGPYALIFASFVPFYLDIPVSKRFNVFGLHFSDKSFIYLAGVQLLLSSWKRSMLPGICGIIAGSLYRLNIFGIRKAKLPGFIASFFSRMSLPSSSSHSQAPRRTSPSLGRQAVRSYQAPIPSSIEPSEEAIATLVSMGFDQNAARQALVHARNDVNAATNILLEAHSH
The following text describes a protein:
Function:
Regulates body size probably independently of the TGF beta-like dbl-1 pathway. However, may regulate some dbl-1-mediated transcription. Plays a role in cuticle collagen fibril organization. Required for embryonic development.
Subcellular Localization:
Secreted.
Domain:
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence:
MLLPLLISGLLFRNADAFLPFFNEDDLKYTFGVDTHAEVPNHEEIDPVPYYHQNGSLHKLEFMAFNKKYNLSLEPTLAKLLSSGVTVVKKNEKKGGSLDFGSTLDSCHYHHYGEKVYAAISNCDGRIKGTVIDDGEIIVVHPFPDHHAHRSKRATENGAHVVYKRETLAGEPKDFCGLDNVVTEESLVEDESAIFEDVFVTGQRLTQQSDLIVELAVFVDENLWRHFSSKHGGMADRKLQDYTLTLLNNIQIMYYQPTASPPLTFRVIRYEVLTRQPSALAGYLHNHGNAQMYLDRFCRYQRNLAVRDWDHAIMLTGYDIHRGAGSRSISGIARLDGMCDPWNTCTLAEGLDFTSAFIGTHELGHSVGMRHDEPYCQSKHIMSSSLGPGKVTWSTCSLRDYHQFLQRLDGRGKNCLRVSNMPNKLEISSNVKPGQIYDANLQCELMHGNGYQQVTPRQDSYDGICYMMWCGQSSFGRIITSHPALEGTFCGPSKWCQLGRCVPWTGTNEIQPTVQHVAPVVTTLPSRIDGSWSGWGATICSQCTCNGILGSVGLAIARRTCSAPYPANGGSDCVGSTSRAVLCSRQCGRASKSVDEYISDKCMEQKRLKNDRELTGKGSQLNRFPQRACKVFCDVQQHYGSQRNYRFFGDNLPDGTSCGYDRYCLDGECLALNCNNNALISRDQSCPTDTCPITDQSSSVYRGQWGTWSLWTSCTATCGGGYRKRNRACSITGQCEGNEDETEVCSSESCPSVLRVGNEWSTWTEWNHCSVSCGRGSQARYRKCLSPHRTLAFDCPEKNIEVRSCDNGPCNAIGVWGTWGGWSTCSTSCGPGTLVRQRTCNREPCDGSAHERRSCNVATCQNDGIWSLWNEWSDCSRVCGKGLRSRSRSCFGSGCMGASSEQQFCNEQACASSSANDWGTWSGWSQCSVSCGAGVKRRTRTCRTGNCPGNYKESAICNDRDCENKNAAWGGWGYWSSCSETCGDGVRKRVRKCYGSGNCDGQQYEKQYCNLRVCDFRRKF
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).
Sequence:
PEEREKTSVDTQVSVGGFDRDIKAVDLVKYLENEVGGVWRCRLKTSCTPSESYPNFFIENVAEVQKTDDYEKVEPHAFVHFATSTYITRAMDAAEHMELFLNGRALKVSLGPENPFRLNQRGGTSAPLKLPDVYVEIGSLVTQDEFFVSWRGPASGTDFLVDPFDGTCKFCFTKDTAFALKSSAEHAVIKCEFKVFLVREIDIVKQYSELPRVAILLWLASSPRICYRTAKDDIEVLVPFDLLDDDDPWIRTTDFSPSGAIGQCNSKQRVQEDCLSQPVTIREEPDFEVPVEDPFFCMHYKEGVSFEIMFLVNAVMHKGILNQHQLSDSFFDLLRCQPREVIVTALKHIYSYKRPVFDAYEKLKDVQECLIKNPKLNEGPKNIDDIAEVRRLVITPTKAYWFLESKDVADRFLRVTFMDEGLQTMNANVLSYYVAPIVKDITSNSFSQKTGVFKRVKSILSDGFNLCGRRYSFLAFSSNQLRDHSAWFFSKVGETSVLDIKNWMGEFTAKNIAKYAARMGLCFSSTHATVEIPPTEVDHELPDIKRNGYVFSDGIGKITPDLAMEVAQILKLDGSPPPSAYQIRYAGYKGVVACWPAKDDGIRMSLRGSMKKFKSCHTSLEICSWTRFQPGFLNRQIITLLSTLNVSDEIFWTVQASMASKLNLMLVASDVAFEVLTASCAEQGNTAAIMLSAGFKPQTEPHLQGMLTYELGELKECQCFIQVSESSLENCFSKHGSRFAETKKLQVINGFVVIAKNPCLRPGDVRILEAVDRPELHHLCDCLVFPQKGDRPHTNEASGSDLDGDLYYVTWDENLIPPSKKSCPPMECTPAEAKPLTCHVNHQNLGQICNAHVVHADRSEYGAFDENCILLAKLAATAVDSPKTGKIVTMPSHLKPKKYPDFMEIEEYQTYKSNKILGRLYRQIKGAYDENISVSSEVDINPVDIHYDTDLEVPGSVDFTADARNQKCSYDGQLNGLLGQYNVNRKEFRHIWSMPKYNSRKQGELQERLKHSYSAFRKEFRQVFEKMNSDFELSDNEKNVLYEQKASAWYQVTYHREWVKKSLDLLEQGSARSVVLLSFAWIANDYLARIKIKCQEMANIGKSKPVNNLARYVADRI
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MPLAGAVPSAAILLLVVLSAEGQPFKGLVPKNGSVGLIGNNVTATADAAAMCYRSAVNEEARPSKTVVDVAPLAVCLALDDAVLLPRPLLLNGAASVPSPAAARQFVPPPLPADAPAPTPGASPEDEDKKGLSGRAKAWCCGALAVGITIVVLPGAEIYLIHATIYLTQALSVDDAPVVDGDGDGDGELFDCAICMETVPGVRKFSVGSCGHAFCSGCVAQYVAAKLGENVARVKCPDPSCKNGAVEPESCFGIISSDLLDKWGFLLCESALGGKKMYCPFREWLFCARCAAPWHAGVGCKEFQELGQDERGREDFLLRRLAGRQRWQRCPQCKMYVEKSEGCNYIKCRCGCSFCYRCASKVSAQTHYCGMCKR
The following text describes a protein:
Function:
Converts 15-cis-phytoene into all-trans-lycopene via the intermediary of all-trans-phytofluene, all-trans-zeta-carotene and all-trans-neurosporene, by the introduction of four double bonds.
Subcellular Localization:
Cell membrane.
Sequence:
MKPTTVIGAGFGGLALAIRLQAAGIPVLLLEQRDKPGGRAYVYEDQGFTFDAGPTVITDPSAIEELFALAGKQLKEYVELLPVTPFYRLCWESGKVFNYDNDQTRLEAQIQQFNPRDVEGYRQFLDYSRAVFKEGYLKLGTVPFLSFRDMLRAAPQLAKLQAWRSVYSKVASYIEDEHLRQAFSFHSLLVGGNPFATSSIYTLIHALEREWGVWFPRGGTGALVQGMIKLFQDLGGEVVLNARVSHMETTGNKIEAVHLEDGRRFLTQAVASNADVVHTYRDLLSQHPAAVKQSNKLQTKRMSNSLFVLYFGLNHHHDQLAHHTVCFGPRYRELIDEIFNHDGLAEDFSLYLHAPCVTDSSLAPEGCGSYYVLAPVPHLGTANLDWTVEGPKLRDRIFAYLEQHYMPGLRSQLVTHRMFTPFDFRDQLNAYHGSAFSVEPVLTQSAWFRPHNRDKTITNLYLVGAGTHPGAGIPGVIGSAKATAGLMLEDLI
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MFRTTLLKSLRASVSKPSIVKTIQSSSRSLFTITTITNNKNVTPLTSSMNFIRCYSAFPELTRDIAKERIIELLEGYDKVDQSKGEITEQSSFTSDLGLDSLDVVEVIMELEHEFNIQIPDNEADSLKTVGQTIDYILAQPDSC
The following text describes a protein:
Function:
Surface-exposed protein required for multiplication and intracellular growth.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MPNRRRRKLSTAMSAVAALAVASPCAYFLVYESTETTERPEHHEFKQAAVLTDLPGELMSALSQGLSQFGINIPPVPSLTGSGDASTGLTGPGLTSPGLTSPGLTSPGLTDPALTSPGLTPTLPGSLAAPGTTLAPTPGVGANPALTNPALTSPTGATPGLTSPTGLDPALGGANEIPITTPVGLDPGADGTYPILGDPTLGTIPSSPATTSTGGGGLVNDVMQVANELGASQAIDLLKGVLMPSIMQAVQNGGAAAPAASPPVPPIPAAAAVPPTDPITVPVA
The following text describes a protein:
Function:
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
Subcellular Localization:
Cytoplasm.
Sequence:
MPLYLVTVASSAIRSPQHLYLLAGAELMPSAVTSLADQLLHDPVVQQVHWQVVEDGQALTDPFLPPTDALVIEVAYRPGVTDSEGESVVEGARRLGIRSLEHARSLRRYILPATTDPAQAAADLAIDVVQTTIAYHPGDQTTARAAFYALLVAEPHPTTPHVAMVPLRTADDAELMAISQRGVLALDLAEMRAIQAYFVAQGRDPTDGELETIAQTWSEHCSHKTFKARVQYSQPPEDLSVDSEHYPMLARLAVGNCTIDSLIRTFLMRATQEVLSGRQDEWVLSAFVDNAGILAFGDRHEVSYKVETHNHPSALEPFGGANTGVGGVIRDVLGVSARPIANIDVLCFGMPDAPPPPAGVLHPRRIASGVVAGIRDYGNKLGIPTVGGAVLFDPGYTANPLVYCGTVGLAPRGLHPRNVRPGDIIVVMGGRTGRDGIHGATFSSIELTHTTASEVGSAVQIGDPITEKKMLDVLLQARDAGLYSAITDCGAGGLSSAVGEMGAELGAEVHLEHVPCKYAGLQPWEIWLSEAQERMVLAVPPDRLIALLTLCTAEEVEATPIGRFTDDKRLRVFYRDLAVVDLDMHFLHEGRPQRVLNAEWQPSPALSQSPHLTNVDPEQALLALLAHPSIASKERIIRTYDHEVGGGTVIKPLVGASLAGPSDATVLQPLPGETVGLALGFGICPRYGRHDPYWMALAAIDEALRNVVAVGGDPERTAILDNFCWGDPKQPDRMAGLVRAAAACYDGAVAFGTPFISGKDSLNNEYRDAEGRRVAIPPTLLISALAEVPDIRQCVTMDVKQPGDVIYLLGATRSEFAGSHLAAVGMIDDVGALPRVDLVAARTTFRTLHQAIRAGLVRACHDLSEGGLAVAAAEMAIAGELGLHLVLDKLDVDPITALFSETPSRFLIAVDPAHTAAFEAMFAGLPLVRLGVVTGTPALRVEWQERSLINVPVTTLRDVWQHSLDVINVKDSDL
The following text describes a protein:
Function:
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLKTTKKSLLVFMGVFFLIFGVDQAIKYAILEGFRYESLMIDIVLVFNKGVAFSLLSFLEGGLKYLQILLILGLFIFLMRQRELFKNHAIEFGMVFGAGVSNVLDRFVHGGVVDYVYYHYGFDFAIFNFADVMIDVGVGVLLLKQFFFKQKQNKIKA
The following text describes a protein:
Function:
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrium between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
Subcellular Localization:
Cytoplasm.
Sequence:
MALARRNVQPENRDSTRINAQIRITPVRVVSEEGEQLGIIPTEQALERARDAGLDLVEVAPGERPPVCRIMDYGKFKYDKNKKKNSGSSHTKTKEIRLRPKTGDEDIRTKVRQAEKFLEHKDKVQVSVLFRGREMAHIEEGRKVMEQVIEILSEVGKVETKPQQHGRRMICMIAPK
The following text describes a protein:
Function:
Transcriptional factor that positively regulates or negatively the expression of a large number of forespore-specific sigma G-dependent genes. May provide a mechanism of feedback control that is important for forespore development. SpoVT levels during spore formation have a major impact on the germination and the resistance of the resultant spores.
Domain:
The N-terminal domain binds DNA non-specifically and the C-terminal GAF-like domain is crucial to its correct folding and function. The non-specific DNA-binding activity of the N-terminal domain is modulated by the C-terminal domain, which perhaps in combination with another unknown factor, confers activity and specificity.
Sequence:
MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEVILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEMLERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEVEHKAVETAAGFLARQMEQ
The following text describes a protein:
Function:
May play a role in signal transduction pathways that involve calcium as a second messenger.
Subcellular Localization:
Membrane; Lipid-anchor.
Sequence:
MGICLSTTKVSGSNSGSNNNNANHHRNANKEEAKRRHNHHARNDTTHKHQHQHQERAKNYQQLKTKQHQKTNSRRQTGVIPCGKRTDFGYDKDFDRRYTIGKLLGHGQFGYTYVATDKANGDRVAVKKIEKNKMILPIAVEDVKREVKILQALAGHENVVKFYNAFEDDNYVYIAMELCEGGELLDRILAKMISTTLTSAWFLAIRKDSRYTEKDAAVVVRQMLRVAAECHLHGLVHRDMKPENFLFKSAKEDSSLKATDFGLSDFIKPGKKFQDIVGSAYYVAPEVLKRKSGPESDVWSIGVITYILLCGRRPFWDKTEDGIFKEVLRNKPDFRRKPWPSISNSAKDFVKKLLVKDPRARLTAAQALSHPWVREGGDASEIPIDISVLNNMRQFVKYSRLKQFALRALASTLDDEELADLRDQFDAIDVDKNGSISLEEMRQALAKDLPWKLKESRVLEILQAIDCNTDGLVDFSEFVAATLHVHQLEEHDSEKWHLRSQAAFEKFDIDRDGFITPEELRMHTGLKGSIDPLLEEADIDKDGRISLSEFRRLLRTASISSRNVPPSPSGHRNPRKL
The following text describes a protein:
Function:
Required for efficient biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSAKSDSRNNKAVKSDEPKKRRRKKARTAEVSDSDSSDSESDRAEEDDNEDNEDTTNHVIDEGDVEMMEFDKDDAAAAASAQTMDIPAELQSLPADSANPEFQKFYLNLVTSEFGKDMDELRTSKTFNDNTLGLLVDALKQGVNVFDEKVQGEIVQQQS
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSQFFKRVQRFAKKSPIAAGIPFMGMIVAASYGFSYITQVKYDYIDAKYTTSDPIVSILVHQSEKREKLGLKNAEPIDIRKIYFDLAKDDDDWDFVRVPRQPGEK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSVMEPLSANRTAQFRTLEREARFVSPPKDKSAYPLLYEAVEPHVGSFNALTEGPGGGLLNLGARDIGAKVVFDGKASDENPNYLGNKLALSVTQVSLTKPMSNDGVTAAAERNVFPAEARKRLTTYRGKLLLKLNWSVNDGEETFSEVRDCGPLPVMLQSNRCHLHKMSPQELVEHKEESDELGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGTSYSHYGVQIRCVRPDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVLILKALTDASDREIFDGIVGADTSNSFLTDRLELLLRGFKKRFPQLLNRRQVLQYLGDKFRVVLQASPDMSDYLVGQELLRRIVLVHLGDENTDKSNMLMFMIRKLYSLVAGECCPDNPDATQHQEVLLGGFLYGMIVKEKIEEYLQNIKLQIQADVNRGMPVDFKDRKYMTRVLTRINENIGSKLQYFLSTGNLVSQSGLDLQQVSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCGLLNHFAHKCKISTTQSDVSKIPTLLYSLGVSPAAHVTAAGPSLCCVQLDGKIVGWCSHEQGRIVADTLRYWKVEGKTDGLPLDLEIGYVPASKRGQYPGLYLFGGHSRMMRPVRYLPLDKQDIVGPFEQVYMDIAVTPEEIQNNVHTHVEFSPTNILSILANLTPFSDFNQSPRNMYQCQMGKQTMGTPGVALCHRSDNKLYRLQSGQTPIVKANLYDDYGMDNFPNGTNAVVAVISYTGYDMDDAMIINKSADERGFSYGTVYKTEKIDLSLSRGRGDPVTQHFGFGTDEWPKEWLEKLDEDGLPIIGSYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVTLIGDESNKFQELQYITIKYRIRRVPQIGDKFSSRHGQKGVCSRKWPTVDMPFSETGIQPDVIINPHAFPSRMTIGMFVESLAGKAGALHGIAQDATPWTFSEEDTPADYFGDQLLKAGYNYHGNEPMYSGATGEELRADIYIGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALIGHGTSFLLQDRLLNSSDYTQSAVCRECGSILTTQSSVPKIGSMVTIRCRRCAISFDEAKKIITQQDSEDSIFIDDSHIWEDGQGNKFVGGGNTTTVAIPFVLKYLDSELAAMGIRLRYNVDPK
The following text describes a protein:
Function:
May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response; (Microbial infection) Plays an essential function in adeno-associated virus (AAV) transduction, across multiple serotypes except AAV5. May play a critical role in mediating the endosomal virus escape or in the AAV virions trafficking from endosomes to the nucleus.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Colocalizes with TLR3, -7, -4, and -9.
Domain:
(Microbial infection) N- and C-terminal domains are essential for mediating AAV transduction.
Sequence:
MAVSERRGLSGESPTQCRWGYLSLLVLTLSGCSGRIHRLTLTGEKRADIQLNSFGFYTNGSLEVELSLLRLSLQETEKKLPKVGFSLSRVRSGSVRSYSRRNSHECPLDRNSSNFLVLFLINIKDLQVQVRKYGEQKLFISPGLLPEAPTQSGPPKPDPAGTPKDNHVIHPSPTEMSAVKENQTAPQVSGDKTTPGEHRHSSERQPPTQDPSGKEKDQVLGLGHLNDSYNFSFHIVISSRAEEGQYSLNFHNCHNSIPGQEQPFDLTVMIREKNPEGFLSAAEIPLFKLYLIMSACFLAADIFWVSVLCKNTYSVFKIHWLMAALAFTKSVSLLFHSINYYFINSQGHPIEGLAVMHYITHLLKGALLFITIALIGSGWAFVKYMLSDKEKKIFGIVIPLQVLANVAYIVIESREEGASDYGLWKEILFLVDLICCGAILFPVVWSIRHLQDASGTDGKVAVNLARLKLFRHYYVMVICYIYFTRIIAILLQVAVPFQWQWLYQLLVESSTLAFFVLTGYKFQPAGDNPYLQLPQEDEEDVQMEQVMTDSGFREGLSKVNKTASGRELL
The following text describes a protein:
Function:
Involved in formation and maintenance of cell shape.
Sequence:
MNKLIFKRSSMPGLRTLIYMGLAIALIVLDQKALFFQKIRADLALVVLPLQYLVSVPIKTIHWIAINVTTQQELVADNARLRAHELLLESKLQKLLALERENAQLRTLLKSTAHVGGARVAVAQLLAVNLDPNLQQIIVDKGMRNHIYVGQPVLDAYGVVGQVIHAGLLTSKVMLISDPKSAVPVQDYRNGIRALALGMGSSGKLLLINVPDTSDIQKGDLFVSSGLGLRYPVGYPVGVVTELERDPTKRFATITLQPSAHLDQSQQVLMTWPNKASLAQDVHQELNLKEKE
The following text describes a protein:
Function:
Catalyzes the acylation of sphingoid bases to form ceramides, which are key players in cell signaling events such as extending lifespan and enhancing stress resistance. C.elegans contain specific sphingoid bases, which are unique or different in structure compared to the sphingoid bases found in other animals. Two examples of these distinctive compounds are: 15-methylhexadecasphinganine and 15-methylhexadecasphing-4-enine. Exhibits substrate preference for fatty acyl-coA chains containing carbon chain length (C16-C18) and very long chains (24 carbons and more).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MWRMSYFWHEPYWLPRNVTWPEVPAKFVDLLVPIYLAIPLVIIRILWESTIGVTYLYFRTNAYASRKNITLLGCMWEHMTGGFASVSRAKKILECFWRFSYYTFAFLYGLYVMKNSSWLYDVKQCWIGYPFHPVPDTIWWYYMIETGFYYSLLIGSTFDVRRSDFWQLMVHHVITIFLLSSSWTINFVRVGTLILLSHDVSDVFLEGGKLVRYDAHNKNMTNFMFVLFFSSWVATRLIYYPFIVIRSAVTEAAALIQPDYILWDYQLSPPYAPRLIVFALILLFFLHIFWTFIILRIAYRTSTGGQAKDVRSDSDSDYDEEEMARRERTRLLKKKKNKVSPSTDDDDDEGEEEKNDRKARHRRAPRKE
The following text describes a protein:
Function:
Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate. Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle. Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether. The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors. Cysteine and homocysteine cannot substitute for glutathione in this reaction.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAISSERVEELLRTFRESLKAKGFEIYPFKVGWYNAVLTAAHHLQYPADTLAVLVISTPAMFECAFLPFLQSQSCESLRDPIDQCTAHTLSACISLCFANQFVDVSYDYEMLPSRKPKFLAQTAAHVSGAAYYYQTSDIHNPPWGEKKMFGVCVHPQLGGWFAIRALLVFRDVQAGAGFQQRDPADCVCTQEERIRLLESFNLRWRDWSYRDIVPAEDRYSDQQKQYFITPPGQRRALLRQWGYLTDTQS
The following text describes a protein:
Function:
Multi-functional protein that contributes to the endocytic process, but also to events that occur at the neck during budding and/or cytokinesis. Plays a role as an endocytic adapters with membrane-tubulation activity that associates with transmembrane cargo proteins and initiates the formation of endocytic sites. Contributes to the stabilization of the nascent clathrin-coated pit. Also plays a role in late endocytosis by mediating vesiculation. Involved in the regulation of cell cycle-dependent dynamics of the septin cytoskeleton by promoting septin turnover in different cell cycle stages. May act through the RHO2 signaling pathway to repolarize cortical actin patches in profilin-deficient cells.
Miscellaneous:
MISCELLANEOUS: Present with 4280 molecules/cell in log phase SD medium.
Subcellular Localization:
Bud neck. Note=Concentrates at the mother-bud neck and at the tip of the forming bud. As the bud grows, abundant in the mother-bud neck and in the bud. At cytokinesis, found predominantly at the junction between the mother cell and the bud. Present at the base of shmoo projections.
Sequence:
MTEQRTKYADSILTTKSPYEATETIRIRLSQVKLLNKDFYLLFKELANLKRNYAQQLRKIIAENEDITKILNAQMIESNVLTPQEMSAFRFNSLGELRNVWDTVIEELKSDLKSSTEYYNTLDQQVVRELKESVENNTSWRESKDLHSKLSKNAASIEHYSKNNENSSHLEEARRQWDQQSPYLFELFETIDYNRLDTLKNCMLRFQTSFSDYLLNTTKECETVMTKFLAFEPQSEIDRFAKDASQYNFQLSSSSKEVVPNNASPASATGARPVSVSNGAANTEREKKSPQKDKRKSAFGNIGHRLASASSSLTHNDLMNNEFSDSTNNSSLKSKKSSHTLRSKVGSIFGRNKTKNKRQQQSSSNSHIQASITETPNNSSTRVSSTATSSIYQKQRRPTYSSSKSNNWTPGEASDTPPLPPHATPKNVDAPVTADTPPAQTFTPSEVPPSTPQQSSPPTAKEPDSSNLPKTVPISISQPPLQPQSKTKPLPVEPASPSISLPTATVDNQPSGQVDSRPLHIRAPALPPSRKQNFIHNRDSQLYDSLPNHGSGATPTSSSLSSIPQERPVSTLSSQITGELRELNPQATGSSTSLVGQSLFQHSSLDTSQFGLNASIAEVLNASFKDGMLQNSQLIGEIALNYLPNSVMNSPLPIGINLRINNGAKFEKVILNQAFIERVAPEEFKVNPSFIDSRTLGAIKYSIKEPIAPIVIHPVWRFESHQASVVLTVKMSPSLPDEISQIVIEDLVVFVNIDGANATSALSKPQGSFSKEKKRITWRFKEPVVLTRNGEGQRLIARFITDGLAHESAKGVITKFTISETDNVALPHSGAGSGITLTCQELDENNPFGGEWLDVNTKRTLTTGNYHGLA
The following text describes a protein:
Function:
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.
Subcellular Localization:
Cytoplasm. Mitochondrion. Note=Relocalizes to mitochondria after H(2)O(2) exposure.
Sequence:
MIPMILYASETGNAQDTAERVARAFRANGRAVTCLPMDQFPISALPHTYLLILLTSTHGRGDPPPAMLPLWTALLRSSLPEDILEDVHFALFGLGDSSYERFCYAGKMLLRRMEQLGATKMGEPAWGDERSPNGIEDAFLPWLQQTLDLYLPYLPLISPTPKIIESTVLPPPIYKISPASTSKSVEHDLSLERLSISFPIPNGKPAPVRVEDQARDKASTSRTKPDDWVWATLKKNIRLTSKDWWQDVREIELEFDDPDTKPYTAGSICSLQPQSREDDVNMFLEMMELTSQADEVVTIESLLDEQPLPSHLPPAGTPTTLRSLLTNHLDIRYSPRKSFFEWLRRLSTNEMERERLDEFISDPDEIHTYATRPSRTIVETLADFRFTRIPMSHILEILPPLRRRQFSIASSWEDHPGKVQLLVALIEYKTNLKIPRKGLCSSWLNGLPVGTRIPIHIASPTLFLPQDPEVPIILVGPGTGVAPMRAFVEIRVRQGAAKNTSLYFGCRSSTTDYFFESEWDVHREKGVKIQVAASRDQEERIYVQHLIKRDKEYVKEWIVDKKGWLFISGSSNAMPREVREAVAWCISKEGAGDMTEEESKAYVEQMFEDKRGGEESW
The following text describes a protein:
Function:
Could be involved in the regulation of nitrogen fixation.
Sequence:
MKMIRAILRPEWTEEVTDGLSEAGYYSLTKINVFGRGKQKGITVGDMHYDELSKTMIMMAVEDEAVEEVIKIISGKAYTGSMGDGKIFVSPIDDAYTISSGAKGL
The following text describes a protein:
Function:
Involved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source. Activates the PP2A phosphatase ppa2.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQKQDDFSFKYWTIKVQRGSILKSHEMENLQSTLGFPPPEMTFGNNYISIEYKNQPVVGFFTEDALKMVGTKPEDVMQVSFAKDWAKSRIKPGEEYPVIYPFDWTYYTDYQGTIQRPNAKFIEIDQVIPVQKILNAGQNLWFNEIILFEDELADNGKSMFDVRARVVQGHLILLARLVVRLDKVNVRLNETRIYIDLLNDFLLKDCRKKQATYDKIIKQIPVGGDKAALLDDNNWLSERLDTVDHKIYKLNF
The following text describes a protein:
Function:
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner.
Sequence:
MPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSSC
The following text describes a protein:
Function:
Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the cell from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
Consists of two distinct domains; a N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H.
Sequence:
MLSQKSIQIIKSTVPLLEKYGVEITSLFYKNMFEAQPQFLNIFNHSNQRNQKQPVALANTILQSAIHIEKLNEINLMPIVHKHVALGITPEMYPIVGAHLLGAMKTVMQDEATPEIMAAWTEAYRAVAQAFMDAEEDLYFETEEQIGGWKDTREFVVDRIEEETPLIKSFYFKAYDGKEIATYIPGQYITVKITLPGDGVDVPTDKMRTYVRHYSLSDKPNDEYYRISIKKELGKNTPNGIVSNHFHNNIKVGDVVPMSVPAGDFVVNNDSETPILLICGGVGINPLFSMLKETLVQQPDRKINFIFSTHCESSQPFKEELKQLEDDYKETGNLKINLVYSENQGHINKEIIEKYSTQHVDQAEIAETDVYICGPVPFMMQVNKDLLQLGFHKENVHYELFGPLTPVLEENQMLRGVKNIIEN