lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Plays a role in spatial signaling during cell division.
Subcellular Localization:
Cytoplasm. Nucleus envelope. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, phragmoplast. Note=Localized in patchy areas at the nuclear envelope (NE) of interphase cells. Concentrates at the preprophase band (PPB) and remains associated with the cortical division site (CDS) during mitosis and cytokinesis. During mitosis, associates with mitotic spindles at the anaphase. Associated to the microtubular phragmoplast and the surface of the daughter nuclei at the telophase.
Domain:
The WPP domain is required for the nuclear envelope localization.
Sequence:
MDHSAKTTQNRVLSVKMWPPSKSTRLMLVERMTKNITTPSIFSRKYGLLSVEEAEQDAKRIEDLAFATANKHFQNEPDGDGTSAVHVYAKESSKLMLDVIKRGPQEESEVEVSKDGDVFFDISGGSRAFIEEEEARDLLRPLADPRNSYTKIRFSNRSFGSEAAKFAASVLSSIKDQLTEVDLSDFVAGRPEAEALEVMNMFSSALEGSKLRYLNLSDNALGEKGIRAFASLINSQHDLEELYLMNDGISEDAARAVRELLPSTDKIRVLQFHNNMTGDEGATAIAEIVRECPSLEDFRCSSTRIGSEGGVALAEALEHCSHLKKLDLRDNMFGVEGGIALAKTLSVLTHLTEIYMSYLNLEDEGTEALSEALLKSAPSLEVLELAGNDITVKSTGNLAACIASKQSLAKLNLSENELKDEGTILIAKAVEGHDQLVEVDLSTNMIRRAGARALAQTVVKKNTFKLLNINGNFISEEGIDEVNDMFKDCLDKLVPLDDNDPEGEDFEDEDEEEEGEDGNELESKLGSLKIKQGEE
The following text describes a protein:
Function:
Component of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3. The SAS complex is however unable to acetylate nucleosomal histones. The complex is involved in transcriptional silencing at telomeres and at HML locus. Also involved in rDNA silencing. In the complex, SAS5 is required for maximal histone acetyltransferase (HAT) activity of the complex, suggesting that it may be required to stabilize the complex or help in substrate recognition.
Miscellaneous:
MISCELLANEOUS: Present with 1800 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDHSIEVTFRVKTQQVIIPEQNIRGNELPLRRWQMELLMLDATGKEVEPTILSKCIYHLHSSFKQPKRRLNSLPFFIKETGWGEFNLKIECFFIGNAGKFSIEHDLTFEDDAYAVDYTVDVPHEFSHLNSELSKYFDLPWKVVSPEEEMSLRIADLPWIKSLALIDEDMMTDVVQMILNDPAVQRAIENHPRREQFFMFITQLPDDLLMKIQAFLKLPNKNSTKQERTNFGSDAIHKDEPVKAHNKLK
The following text describes a protein:
Function:
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
Subcellular Localization:
Cytoplasm.
Sequence:
MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAVRRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVIGCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGSGQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVKMARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV
The following text describes a protein:
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MALGGGGPQRGTAAASAANLRRRRTTSGGAAGGAGGTMLQFYTDDSPGLKISPNVVLVMSIGFIAFVALLHVMGKLYFVRKEG
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLNDFNSWYKTQPLFTRTYVSVLVLFGIIGKFKPSYLWYLMFDANKIFPLQIHRLFTHYFFSGTLSFSFIFHLLFIIFCIKNCEMMFEGSNYADFYYMILYFFITGDIMCWLFDYGFLSAAFCFALIYVWCKRKPFETVRFYFGFQFKSEYFPWVLIAFHAITDQDIVQDLIGLGIAHSYLLLKDFLPVTNSIAIIRNTLIFQKLCEQTHCEICTIFKETDLINNNSSNLKGNNSFKDKEYVQVDIQNI
The following text describes a protein:
Function:
Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.
Subcellular Localization:
Membrane raft.
Sequence:
MEAGARPAAGESAPTPAEGGAAAQVGQVGSLSAGVSAARGSACSLAGAGRAKRALGLRIQLWEAGFVSQTLPRKKVMEAEGLRNFKELRAKFQNLDASSLSGPIKFPAGVSQKGDFGSRQSMKTSASGKPPSSSHNQHSPNCADGDPQPLKPQQVKGTQKSETQKCSNYLEQPSFPGSAVRSQKASPLLDVYQSNGEIANKKKVMVNDSFRNKLWSWEVLSQKSETPSIFLPASCGSRAFHLKEQKSIKLTSQEPMENMEIKEAQSLPSHRHLMAQRRLCAISEDPTVQPSQCSRESEANSSPERSLTGSICHPVYDNELTSQTSEEQPDARHPQLPNTKPLPSVESLGPPPPKPPRPPVVTLQAFQRQAAALSKPDGEEATKEGSLPPVSAEFEEPHNYEATISYLRHSSNSINLCTAKKSADSTYEVRIEELRKAWKSFYHQELTPQHEDEDKQMKEKEPYQLKLQNTEDLHLDHLFKVDIYEEIPGKTQMAEDHTGGRIMPARKQDAAMDIIQVEACPEDFQPARLPIDYCGYAKALEMTKETQGQGAIKPNSISENYDDVECSGSKSSDGKASLKRLQRFFKKEKDRLKVNRINSKENIRAFSLSLPDLKLRSQEVIIYDDVAINGKQPNDELKGKSWKLKFLTLKEKKKKGAKESERSFFKIKKQNLQKDRMKREERLFRERFKYDKEITVINTAVVCSNNSRNGISDLPITPGEELDVIDITEENLVICRNSEGKYGYVLIEHLDFKQQV
The following text describes a protein:
Function:
Olfactory receptor. Activated by the synthetic sandalwood odorant sandalore. Endogenous ligand is unknown (Probable). The activity of this receptor is probably mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs. Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes. Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDATACNESVDGSPVFYLLGIPSLPETFFLPVFFIFLLFYLLILMGNALILVAVVAEPSLHKPMYFFLINLSTLDILFTTTTVPKMLSLFLLGDRFLSFSSCLLQMYLFQSFTCSEAFILVVMAYDRYVAICHPLHYPVLMNPQTNATLAASAWLTALLLPIPAVVRTSQMAYNSIAYIYHCFCDHLAVVQASCSDTTPQTLMGFCIAMVVSFLPLLLVLLSYVHILASVLRISSLEGRAKAFSTCSSHLLVVGTYYSSIAIAYVAYRADLPLDFHIMGNVVYAILTPILNPLIYTLRNRDVKAAITKIMSQDPGCDRSI
The following text describes a protein:
Function:
Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MAGRGGYEHARSGFGGDRASKQLPTEPPFIAFVGNLPQGLVQGDVIKIFQDFEVKYVRLVKDRETDQFKGFCYVEFETLDNLERALECDGRIKLDDLSAPLRIDIADRRKNDRPGGGVGGGNGGMTRGDGGRDGFQKRGPPRQGGSSQSYSRGGPGTGGGGREGGGGSGNRGDSRDRPANRGRYGSFNNDDRPFERNQDRDRGQREGSYGNQSRDGDRYNNFNRHRDRERTHYNPNQQSERPSGGMTGLGGGSGGSGGLGVGGGSSMGAIDDNERPRLQLKPRTIAAPINAVAETKQSASIFGNAKPREEKLKELQQNVNHNGDN
The following text describes a protein:
Function:
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
Subcellular Localization:
Periplasm.
Sequence:
MKIYLRFVWILIIILNFLLNLFITTNGVIIVNAFKKSLIVAASFASLSLFNSATAELVYKPLEQPVEPAKPDLKIESVNEKFAEKYPNQYNSWRSTANGDGENIIYADEENPRLIVLWGGYAFAKEYNAPRGHFYAVTDVRNILRTGAPKTANDGPQAMACWTCKGPDVPRLIAEWGEKDYFNAKWAKGGPEIVNSIGCADCHDTTSKDFAEGKPALRIARPHVLRALDALEKATAEKDKAEGRPHNNLSFNTAARTEKRAEICANCHVEYYFAGDIKQVTFPWDNGQTVDDIEKYYDDIGFTDWTHSLSKAPMLKAQHPDFEIWSLGMHGKNGVTCVDCHMPKVQGADGKVYTDHQIQNPFEAFDSTCANCHDQSKEKLRDIVTSRKKEVKDVMGRLEDQVVKAHFEAKEAWDAGATKKEMEAALMDIRHAQWRWDYTAASHGGHMHAPEVVLRVLASGLDKVADARTKLAVILTKHGVKTPVQIPDISTADKAWKVMGIDIEKERKAKEEFLKTVVPQWEQQAREKGLLVDPPAQK
The following text describes a protein:
Function:
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MAEKACVKRLQKEYRALCKEPVSHVVARPSPNDILEWHYVLEGSEGTPFAGGYYYGKIKFPPEYPFKPPGISMVTPNGRFMTQKKICLSMSDFHPESWNPMWSVSSILTGLLSFMMDNSPTTGSVTTTVAEKQKLAKASLAFNCKNPTFRKLFPEYVEKYEEEKVMVHPTQEQVSTIPTQAENSTPLLDGLNKVEPHKDVKNQQRKSCPTWLLLLLVSVFGVVMALPLLQL
The following text describes a protein:
Function:
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MATSSSDRWPIPLKQHIPTLIFITVTVLTSNLVSRTQPTAYLDEIFHIPQAQQFCSALSSTSLFSAQQVWRQLTSVRYDAQLTTPPGMYAISVGMAKVLPGWECKDVVWLRSTNLVLLLTLPVLVARILGQIEEQARIASAAEDYSPSKTITQNLGKEITRHEIEMLQAKAKLQLPPTPSASHDDLAHIEPPTISIAQAALPAPTGSAAPLLRALKQREASAYTMALACTICFLPPLWFFGFLYYTDLASTWLVLAMLSLYNDLNTSNAHVAPTITGLLIALTSILAVAVRQTNIVWIGFAAAQATLSRVGKHVSHTQQGSDPVTQAIGMVKGAFGDNKKGWWTAVAINAAPMVPVLAVCVLFLRWNGSIVLGEKAAHQVALHLPQMGYFVAFALGFGLFPLLFSLQSMSHKAQDQGPSSSTLATFTHSVRSAVSALIDSTIASPGCILALAAALAGFYIAVDRFTIEHAYMLADNRHYTFYIWRKYRSSYAIPALDGMTIEPKLAVVPLFALALIAWSRALTHHAVNKRTGALFSLLFWMATAAVLVPTPLIEPRYFLMAYLLLRIYSHPYAPCEKQEKSAQLKWIYLALEAATYAAVNVITVGLFVNRPFQWPSHAVDVSRNEHTTMRFLW
The following text describes a protein:
Function:
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNQYFLLHTYFQVSRLIGLCNLHYDSSNHRFILNHVPTVVYCVILNVVYLLVLPFALFVLTGNIYHCPDAGMFGVVYNVVALTKLLTMLFLMSSVWIQRRRLYKLGNDLMKMLHKFRFNLGNDCRNRCLCKGLLTSSRFVLLTQQLLTRDSVVNCESNSSLRQAMVPYQSAAIVYALIMILLMSYVDMTVYMVEVAGNWLLVNMTQGVREMVQDLEVLPERNGIPREMGLMQILAAWRKLWRRCRRLDALLKQFVDIFQWQVLFNLLTTYIFSIAVLFRLWIYLEFDKNFHLWKGILYAIIFLTHHVEIVMQFSIFEINRCKWLGLLEDVGNLWDINYSGRQCIKSSGTILSRKLEFSLLYMNRKLQLNPKRVRRLHIVGLFDLSNLTVHNMTRSIITNVLVLCQIAYKKYG
The following text describes a protein:
Function:
Putative Notch ligand involved in the mediation of Notch signaling.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MQLLAISFLFITFIIESIICSGYLELHIQSPHIQTAIVNISSNFRTEKSKIVHLKLKSNVPFNVTRIPVNFDNIYNITIKCGKSEEDGKFNSYFKNSTPKYLGLTDTTIVSTVHPRVGLLSPAAVARPLNGIRIVIGCNKNWFGEKCETFCDENKATNSGKHCNFQGKPSCLNGLTGSKCEKLIVPKLCNCENGGVCIDSNPKPICECSKAYRGEKCEKKHISASLSSHYKGDFWNFRMTFWQLIFSNLVENELAEISKSEAWETINNLLGNVSDTPFANRPNNTETFPITGSVNLDNVDII
The following text describes a protein:
Function:
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.
Subcellular Localization:
Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage (By similarity).
Sequence:
MESMGRQDRRLHQQLKESSSRFQTLMKRLIAKYNQPFEDDPLVEMRTLTYETPQGLRVWGGKLMKKEDKEYTQVIDRLNGQAPEGDSESSGADTSLEENWPSCSSAMREASGDPRQRQPAVPGNTLETDLRRKYLTQVDILPQDEEYFKNAEKRGGKDTVMTWVPSVTSSVTPASGCQDAISAKSSGGPEVSALSSRGQGPSYPCPADMAIVARSDGLSLLGTSSNSVSSQSFEVDDLCNVTISDLYEGMMHSMSRLLRSKPSCIISTKTYINQSWKLRRRPSRKQGLHKNRTHCPRSKPSQRSARKGPASCSEPGKEAGILRDYGNLLHVAPHKTGLELKSVSLEGSKRQVHKSSPAWKELQMMPQKDLDLNRERENRVMTLQWLISPVKVVPRPRMLPSQVEKWYREIKIKFDKLHQEYCLSSGKQPRLTDPTESWAVDVYRSGSKSPGSRQDVETCRPSSPFGREKTERPGEALEDLRGNGKSVKTKSCLLRSCPSPEGSPSRSPSHSQLSSGLQEHNSEPTGKAVWPSTAISAPSIGSPGCGKDNYYELKKEFNRLYQKYCLSPQRAKVTSCGRVSPMKAAAALPCQSEHLKRLNPDSPQQSSQKRSISPGCHRRVLQDSTAQTASTLVRDSWLPTKRCKLSYPVACAHQAKFHDTSGASGWP
The following text describes a protein:
Function:
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Sequence:
MKYSQNQIVYVIFFFIILIVVKPIESVEWSDCSDPSDSFKIEKLEFSPEQPIAGQDLIISVSGYLNKEITKGEAYLAITFDRIPILKLKGNLCDGMGVTCPIPQGNYSTTTINQEIPENVPQGYYYVNFVLYDQDDLQITCVDVQMNITQS
The following text describes a protein:
Function:
Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products.
Sequence:
MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPRRVVNQSDAADRVAELFLDPGQRERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPATIRDRMHLFYEHAVPLAVDVSKRALAGLPYRAAEIGLLVLATSTGFIAPGVDVAIVKELGLSPSISRVVVNFMGCAAAMNALGTATNYVRAHPAMKALVVCIELCSVNAVFADDINDVVIHSLFGDGCAALVIGASQVQEKLEPGKVVVRSSFSQLLDNTEDGIVLGVNHNGITCELSENLPGYIFSGVAPVVTEMLWDNGLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDVLARFGNMLSVSLIFVLETMVQQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR
The following text describes a protein:
Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Subcellular Localization:
Chromosome, centromere. Nucleus.
Sequence:
MAPVRGSYRRGYDQEAMENAIQRVKLGEVSTREASRLYKVPRATLMDKLANRVPLNCRSGPSPKLPIADEANCAKRVIRTRAMAPVRGSYRRGYDQEVMENAVQRVKLGEISMREASRLYKVPRATLMDKLANRVPLNCRSGPSPKLPIAEKGNSAEQGKKRKKTIKLANRVPLNCRSGPSPKLPIAEEANCAEQVIRTREMAPSPDLPIAEEVNCAEQVIRTGAMAPVRGSYRRGYDQEAMVNAVQRVSLGEISVREASRLYKVPRATLMDKLSYRVPLNCRSGPRPYLTMDEEANIAEWVIRMAKIGYGQTLSDLKQTVKKILDDDGRPTPFKDNLPGKKWMKEFQHRHPELVMRTPQLLGKERAVLSVEVISRWYNQLEDFLTCENAASILTEPGRMFNCDESRFVLGEGRNQNILAKKGEHDVTSVGNSDKRQITVLANMSSDGTYLPPLIVFPGVRLSPVVAEGAPEGSYIGGSPIGRMNSEVFFCYISNCFIPFVKQKGVNFPVLLLVDGDRSHLSFELNELCKVNKVILYCLPPNASHMIQPCSLSLFSSLKEKWAATESKYRMENEGAPVSKVMFAREFDKAWTEITCDPMVARNGFRAAGLFPFTKTCMGDKLLPATVFVRTPATQDKPAKAAAGQAPDAPPAPPAQPDAPPNTSIDAGGKSFVSPSLKHHLRFRPITVPPKKRETLKTKRQKKEEEQKNKIKRKEERKRKTTEKEEAKKKKKKKKTVRSADREEAIDKVYTCGDCGGVNSSAEISAKLITSTHGVDQGSTYSPVECHDCHAMVGKVYRTTPRLLDDLRDNYTLDANKLSIYQIGSATTTVSPADDAASSLLNMTDLKTLKETMLKLQVLMCTMHQRIANIEQSLEIEEIDPVGPTQDLIPQVLSPIPKQKQSNGNKDMGRVSQNTSMQLGSNISSSANSDGSGPKENVPSKKKSKRRGVDSRESVSLEERVKKRERSTKRLKKSGND
The following text describes a protein:
Function:
Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MTAVWMGIVGVVLVGLAAPVTGGDGIERLLEAQDRMRLRRMRRGVNAAHWYSQTSTYSAQRFTAADFALLKQLGLNHVRLPVDESWVANSTYGFDAQLFAEVHTGLQRILDAGLAVILDFHATETFHAKLRDGTISTATFCALWRGWATHLAHYYSPDVLFLELLNEPSFPTVAPWDAMAQALTTCIHEARTCVAPDFTVIVDANLRVSENAWNTYAALAQMTPPVNKRHVVYTFHTYDPGVFTHQGATWGWYAYQMLHDLPYPSTPTNVATLAAAETNSTIRNLIEYYGSLQWNAHRLFNTLAPAFDWLRQHNLSAVCTEFGVYRLVSPPAAIPRWALDAAALLDAQGIGRLMRSSLCDMRVLLMSRLGDSRIFDAGMGVGPSLSNGKALINSTLDALVHWGHQQEPASQDPHCAARSVRPRRAYPGAQLGAGVSFNATWYNDTTVVAAPNLYSPIAPSPLGVTLLSLNGSVAAEAELLERILQEAMARHEAVAVFISLSPIPPDFLKNWSSTPEAGPGVLPVANVASAADADTFCAWLTQAALHNAVRHDDCGYAMGGVVAGGAASNDPGLLCAWFSQLACTNASLGVVRASTGFTLSDECFDFVGLPLDDPRADSGALDAQAAAIDWPSAVTEVLAMTTVNSSTIATETPSLAEVQTLCAAGSDGPVGVPLLAQLVAHLAKVDATAYATYLRGSTSLCLAWQAALGLSTVQPDTTTTNSAAAVGGDSAFPIPSGGQLLSLEFGRSRCTRR
The following text describes a protein:
Function:
Promotes neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes and thus regulates SCF-type complex activity. Function promotes cell proliferation.
Subcellular Localization:
Nucleus. Note=Predominantly localizes to the nucleus in eye imaginal disk cells.
Sequence:
MNKLKSSTHRDKVKKFISLTHTGEQTAIFCLQQNDWKFELASDNYFQNPEYYYRELDRKRIEQLFMRYRDPSDPLKIGSQGVIHFLEDLDLKPDSKLVLIIAWKFHAEVQCEFSRDEFINGMCDLGIDSIDKLKTKLPILEQELNDAGKFKDFYHFTFNYAKDPGQKGIDLEMAIAYWCIVLSGRFKFLDIWCQFLEEKHKRAISRDTWNLLLDFATNIDDRMSNYDSEGAWPVLIDDFVEWCQENDHLKEDSSPASGYQQQSSASSSSQKNISSAYQTSHSTNMNYG
The following text describes a protein:
Function:
Essential tubulin-folding protein involved in the final step of the tubulin folding pathway. Required for continuous microtubule cytoskeleton organization, mitotic division, cytokinesis, and to couple cell cycle progression to cell division in embryos and endosperms. Not essential for cell viability. Binds probably to the multimeric supercomplex, stimulating GTP hydrolysis by the bound beta-tubulin and the release of the alpha-/beta-tubulin heterodimer.
Miscellaneous:
MISCELLANEOUS: Belongs to the PILZ group of genes that disrupt, when mutated, the microtubule cytoskeleton and produce mushroom-shaped ('pilz' in German) embryos.
Subcellular Localization:
Cytoplasm. Note=Not associated with microtubular arrays.
Sequence:
MEDDGQSSVAETLDPALQKKHHDMLERLSARHQARKSDSPDSSSSSSSTLESTSSFLAKFSDSKRSIESRIAESRLASSSTDSSKLKSDLAEISVAIDNLEKLLAENSYFLPSYEVRSSLKIVSDLKQSLDILSGELVPKKKFSFKSKSTTKKPESKLPEIQKPDVVLPPKLVPVRDSPGLRNKHGETLVKSFEGSSIGEFTLSDLDSCQVKLTGTVNALFLHRLKKCSVYTGPVIGSILIDDVEDCVLVLASHQIRIHCARKSDFYLRVRSRPIIEDSNGVRFAPYCLDYKGIDEDLKTAGLEEETNNWANVDDFRWLRAVQSPNWSLLPEEERVSLLTISGDS
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRITSTCCICPVLVCLCFVQRCYGAAHHGSIKVTRNQTKHIEGETEVHHRPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSEMGTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESAQVGSAVGKIKANDADTGSNADMKYTIINGDGAGVFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDVTMLKIIVGDVDEPPLFTMPSYVMEVYENAKIGTAVGTVTAQDPDTANSLVRYFIDHNTEEDRYFTIDANTGTIKTAKIFDREETPWYNITVAASEIGLCKAVPESRNGPTTGHRTSAVCGALIYSGDNPGLVSHVPVGIRILDVNDNPPELAREYDVVVCENAKPGQVIQTITATDKDNSANGARFHFSLDEGLSLNPNFTLRDNEDNTASILTRRRRYSRTIQDIYYLPILISDGGVPPLSSSSTLTVRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVVILLAIVVLFITLRRSKKEPLIISEEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDVRPEVKPAPRHHPSSSLDSINVQEFIKQRLAEADLDPSVPPYDSLQTYAYEGHRSEAGSISSLDSVTTQSDQDYNYLGDWGPEFKKLAELYGEIESERTT
The following text describes a protein:
Function:
Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme.
Subcellular Localization:
Cell projection, cilium, photoreceptor outer segment. Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MLETLKVSSKMSETPSTSFSMIRLTSSEGQVPSRHSNVTHPTVAKRISFYKSGDPQFGGVRVVVNPRSFKTFDALLDNLSRKVPLPFGVRNISTPRGRHSITKLEELEDGESYVCSHNKKVLPVDLDKARRRPRPWLSSRSISTHVKLRSATATMPTTAPGLFRAPRRLVVFRNGDPKTRRVVLLSRRITQSFEAFLQYLTQVMQYPVAKLYATDGRKVPSLQAVILSSGAVVAAGREPFKPGNYDIQKYLLPVKLPGISHRVHRKGKAKIEKRKSGNWKVLIITSDFPNAGTSSQVYIVLYGHCRSSAPIYLSGRDGTRFQDGHEDNFTITVGDIGIPFKIRVGHTNSGCSPSWHCKGIELQNMNSGQKFYIPVQRWLAQEQEDGEICREFPILSKGQPVLPVTTYEVYITTGELWNAGTIANVYLSIYGEKGDTGSRKLFRSKNSLKFLRGQIDTFFLEAVNLGVLCKIVIGHDGLGQGNGWFLEDVVVRDPTTNHEYAFFCHRWLDEGEDDGKIVREIYARDKTIFSVRKKLERKRKETWAAERWKFMKGNTLQFYNKLTGGFVRLHPDGSVDAAGEQTDRYSLFDVIFNKGNICVFQSHEMRHLSLTLDNGFVTGMAGGGACSELRVLHQPNHCALLESVLLPGHTLTVDRQGKVADESSAGYAELSKEFSVFVKGVFLNSAVVILATSLCQALCLQPNGTCTGAGSQSEQSYWRVHRIRSGICMFESVKTAQMYLRIKDGCCNGMGTGDTDCHFKIKKNLENASISLESLKSPGLFVGLQPDGQAKPVIYTKNESVCFYPRVIQFGRENPMGMSATPSQGENKTRPPESKTRCPSPLSSEKESRHSHSTENLLSEENWKVLVLTGDTGTQANVTLWVYGDEGITGPISLTKDSQEQLFLPGKMDEFQVVLRGIGEIYKIRIGHDGTGGQPEWSLKRVTMENVKSQKTLNFDANVCLSRNQADGDIVCELPVMKEGKPVFPLVRYHVDVYTGQLKQAKTESEVSLCLYGERGDSGLRLLHRSNMPVRFQRGQIDAFQIEAVSLGNLQKVLLHCEARDKSHYWYCEKVIVKEPGSASESIFTCERWIPFMSQGLMHSEIELYCQEMQTNHPSKIQEEANDGDWKVTVVTGDLENAGTTATVSLCVYGEARCSGPIILGSGKHHLFNPNSADIFKIHLKDIGEIYKIRIGHDNSGENPRWYVEEVILENMATCELLCLTVDSWISDSEDDGDTWKEVPILSAHRGSLPVVTYKIHIHTGTKPGAETESNVFINLIGTNGDSGKRRLHQSRSRKVRLHHGQVDMFSIKAVSLGKLKKVLISHDGTGPGNGWFLKNIIVKYEEEGSCEEVLFPCHRWLDEYQEDGRTERELLRK
The following text describes a protein:
Function:
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNRPSWSTAFNIGGGFPIQWYGIIVSIGIIFAILMFVFKLIYCYKLQDNSFYFFIFIAVLTMVLGARLWSFVIGDSNFANNNFFDFRNGGLAIQGGILLTSIVGVIYFNFFLNSKTNKTKTIAELLNNKNEIKAVYVERNISVLVMLDLIAPCVLIGQAIGRWGNFFNQEVYGFALAGTMNDPQALANTQWGFLKILMPKVWDGMWIDGQFRIPLFLIESFFNTIFFVLIYFVMDFIRGVKSGTIGFSYFLATGIIRLILENFRDQTFYFQTSITTSILFIVVGILGIFYCQFIHVKLRNYFWTYFFLYAFYKVAAFFTTLFLNNRKQMAQQKFAFYEKSLPNKKRSFFEMKYYNDVTTPKIYRLTDQEMKLFDKLEAVTTS
The following text describes a protein:
Function:
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
Subcellular Localization:
Cytoplasm.
Sequence:
MNALERLEKLLDKEQFEKVKAIDNPELHEFLAEWIEWLEPDKVFVCTDSPEDEGYVRWKALYYGEERMLETPNHTVHYDNYYDQARDKANTAILLPGGKKLPYINTKDRDEGLKEIRELMKGIMKGKELFVCFFVLGPKNSIFTIPAVQLTDSAYVAHSEFILYRKGYEEFKRLGRSARFFRFVHSAGELDERKTSKNLDKRRIYIDLEDETVYSVNTQYGGNTIGLKKLAFRLTIKRAVEEGWLSEHMFLMRVNGPHGRKTYFTGAYPSMCGKTSTAMIPWENIVGDDLTFILPVNGIARGANVEKGVFGIIQGVNPEDDPIIWQVLHSPVEIIFSNVLVKDGKPYWNDMGIEIPDEGENHSGKWWRGKKDAEGNEIPPSHKNARFTVSLEHFPNVDMEALENPCGVEVGGMIFGGRDADTWPPVREAFNWEHGVITMGASLESETTAATLGKEGVRAFNPMAILDFMSVHLGDYLRNYLEFGRKLKKTPKIFAVNYFLRENGVWLNHKLDKAVWLKWMELRVHGDVEAIETPIGYIPKYKDLAKLFKDVLNKEYTKEDYERQFKIRVPELLAKIDRIEEIYRKLDNVPEELFKVLEEERQRLLEAREKYGDYISPFALEGE
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MEIDENSCSSIDARDDHACGFKCNICLEVAYQDPIVTPCGHLYCWPCLHRWLRVCLSQSNKPRCPACTAVIKERKMIPIYGIKSDRRSPSVLRGIKFPNRPSPFSSSLIGRAVCQTLNAIASAFNASFSSSSIGRAVPQTLEAVASALNTDHFSKVFEFMPMVLGGIGVVVLSGGYFWWLSKPLASTKQVLDSVEQVCDSWETCDGKRLVCGGWKKVKAMCSLGLRVFYCLI
The following text describes a protein:
Function:
Cysteine protease that cleaves specifically after arginine or lysine residues. May play a role in apoptosis.
Sequence:
MEKIYVKIYELSGLEDKDNFSCYIKIYWQNKKYKSCILQKNPYKFNEIFLLPIDIKNNVKDEKNNILSIEVWSSGILNNNKIAYTFFELDHIRRERISSEKINLIDVVKKCTLQISVHIINNNQDILFCNIKDIFGNNKNDKEIHDAILKYGGNERHIIKELRKEKEIGQYNNIYFNDYVNVLNTDPSQNYIYNDMPKITPNNIYNNMNNDQTNHTYLKAPNSLYNNENTIYSSNVHYSTYMNNSPTYKNSNNMNHVTNMYASNDLHNSNHFKPHSNAYSTINYDNNNYIYPQNHTNIYNRASPGSDQTLYFSPCNQKKALLIGINYYGTKYELNGCTNDTLRMKDLLVTKYKFYDSSNNIVRLIDNEANPNYRPTRRNILSALMWLTRDNKPGDILFFLFSGHGSQEKDHNHIEKDGYNESILPSDFETEGVIIDDELHKYLIQPLNEGVKLIAVVDSCNSGSSIDLAYKYKLKSKKWKEDKNPFHVICDVTQFSGCKDKEVSYEVNTGQIAPGGSLVTAMVQILKNNMNTPSIITYEYLLHNIHAHVKQHSNQTVTFMSSQKFNMNRLFDFEHIIKNKNNQLGQIINKYIEKNKSKNKNKLKHELKNLFFF