lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Sequence:
MDSLFVEEVAASLVREFLSRKGLKKTCVTMDQERPRSDLSINNRNDLRKVLHLEFLYKENKAKENPLKTSLELITRYFLDHFGNTANNFTQDTPIPALSVPKKNNKVPSRCSETTLINIYDLSDEDAGWRTSLSETSKARHDNLDGDVLGNFVSSKRPPHKSKPMQTVPGETPVLTSAWEKMDKLHSEPSLDVKRMGENSRPKSGLIVRGMMCGPIASSPQDSFHRHSLRRSSPSSSSTQPQEESRKVPELFVCTQQDILASSNSSPSRTSLGQLSELTVERQKTTASSPPHLPSKRLPPRDRARPRDPSEDTPAVDSSTDMDRMPLKLYLPGGNSRMTQERLERAFKRQGSQPVPVRKNQLLPSDKVDGELGALRLEDVEDELIREEVILSPVPSVLKLQTASKPIDLSVAKEIKTLLFGSSFCCFNEEWKLQSFSFSNTASLKYGIVQNKGGPCGVLAAVQGCVLQKLLFEGDSKADCARGLQPSDAHRTRCLVLALADIVWRAGGRERAVVALASRTQQFSPTGKYKADGVLETLTLHSLTCYEDLVTFLQQSIHQFEVGPYGCILLTLSAILSRSTELIRQDFDVPTSHLIGAHGYCTQELVNLLLTGKAVSNVFNDVVELDSGDGNITLLRGIAARSDIGFLSLFEHYNVCQVGCFLKTPRFPIWVVCSESHFSILFSLQPGLLRDWRTERLFDLYYYDGLANQQEQIRLTIDTTETISEDTDNDLVPPLELCIRTKWKGASVNWNGSDPIL
The following text describes a protein:
Function:
May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling.
Subcellular Localization:
Nucleus.
Sequence:
MEAAAGGRGCFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPVLHLPAIQPPPPVLPGPFFMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKDKPSSWLRTLAGSSNKSLGCVHPRQRLSAFRPWSPAVSASEKELSPHLPALIRDSFYSYKSFETAVAPNVALAPPAQQKVVSSPPCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAGSEGAAELEP
The following text describes a protein:
Function:
Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. Activates the transcription of the uhpT gene. Acts by binding specifically to the uhpT promoter region.
Subcellular Localization:
Cytoplasm.
Sequence:
MITIALVDDHTIVRSGFAQLLNLEQDIRVQGEYESAKAAFYALTQAEVDVAIIDISMPDENGLSLLERLRQHNPRFKAIILSIYDSASFVKKALDAGAQGYLSKRCGPSELVSAIRTVASGRRYLCADALVNLSNPDINNVLADLTKREVEVFDLLVQGKEVKEIAQTLFLSHKTVHVHRANILSKLNLTNNVDVIRFALQHQLLVEG
The following text describes a protein:
Function:
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAMEF6) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding.
Sequence:
MSIRTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWPFRRLPLRPLIKMPCLEAFQAVLDGLDALLTQGVHPRRWKLQVLDLQDVCENFWMVWSEAMARGCFLNAKRNKTPVQDCPRMRGQQPLTVFVELWLKNRTLDEYLTCLLLWVKQRKDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTPYLGHMRNLQKLVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLCCLQKLSMNSVSFLEGHLDQLLSCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPISMATLENLLSHTIILKNLCVELYPAPRESYDADGTLCWSRFAQIRAELMKRVRDLRHPKRILFCTDCCPDCGNRSFYDLEADQCCC
The following text describes a protein:
Function:
Secreted immune-induced peptide induced by Toll signaling. Has a role in resistance to bacterial and fungal infections.
Miscellaneous:
MISCELLANEOUS: Not induced after bacterial challenge in strains carrying a loss-of-function mutation for Toll. Constitutively expressed in Toll gain-of-function mutants.
Subcellular Localization:
Secreted.
Sequence:
MKCLILSFAIFVVLASQATAGNVIIGGVCQDCSPPVAENVVVGGQSYRTGRPGQGTVYINSPGAYLGALDGPIRRTGAGGGGGGGAQYPDGYSGRLPGGTYLHNKDCVGCSISGGGD
The following text describes a protein:
Function:
Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function leads to apoptosis (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSPVESSNVEKDIFRDTPVRFLGKRYANEVGEAFRSLVKPVVVKFSYVVAFGYVAADSVDKGFKESKKPHANDTEKAKRVAIIAVDTVLWQTFASVLIPGFTINRFCFFTNMLLEKSTKLPTNLRKWTVTALGLATIPFIVHPIDAFVEDAMNKTARKVYNY
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
LKCREKEREKISFFLRKAIVGKETEIDSDGREGGTMNTKKSLFIAGPPGTGKTASVRSIIAEFQEEQALGNIPEFKFIDINGMELRHPYDAYVKFWEAISGIRKERETPGNAAAELENYFVNDEDYGDEEDIPRKPVTVLLLDEIDYLVTEKQTVLYNFFDWPLRCLSCARLIVIGISNTINLPERLTPKLQSRLGWDRVHFQSYNANDTITILKTRLDMMGADFDPTTAVFDEDGIKYAARKTANLSGDIRKAFHMMKVAAEKVFEEYTTGQRHLADGARPMVKISDVTRSSRDMFHSIIHRAIACSTAYQALILIAIGAMKRNSGRENGFTAKEILVKIESISDGSGETRYDARLAWADLIEMLNRLAVVRASVLPCWLPSCTFHSLSLLTLIFAVWNYPIDLSLHQQPMAIGFNQSSCLRNLGIIQKHVSQQVSRETSC
The following text describes a protein:
Function:
Catalyzes the conversion of uridine into UMP and cytidine into CMP in the pyrimidine salvage pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPEAFERYSSNPTYEPPWRKVRFIGIAGPSGSGKTSVAQLIVKALNLPHVVILSLDSFYKSLNAEQKKRAFNNDYDFDSPEAIDWDLLFVKLLELKQGRKVDIPIYSFNEHNRLPETNTLFGASIIILEGIFALYDEKIRSLLDVSVFLDTDSDVCLSRRLNRDINYRGRDIVGVLEQYNKFVKPSYENFVRRQLSYTDLIVPRGRDNKLAIDMVINFIRRTLSIQSETHVKNIDSLQQIVPTIPHLPLNLVQLKITPEISAIRTILINKNTHPDDLQFFLSRIGTMLMNLAGDSLAYEKKTITLHNGNQWEGLQMAKELCGVSVLRSGGTLETALCRQFPTVCLGKILVQINKVTQEPTLHYHKLPRGIATMNVVLMASHLTTHADVLMATQILVDFGVPEENIIIVVYVCYSESIKALAYIFPKVTIVTAFLESVAEPVVGRLDIEKVYYGC
The following text describes a protein:
Function:
Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS/BtsR and YpdA/YpdB, and their respective target proteins, BtsT and YhjX.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTPSNYQRTRWLTLIGTIITQFALGSVYTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALLMIVFGATLMKDAPKQEVKTSNGVVEKDYTLAESMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASLFGGFYVTFYVIFALLILSLALSTTIRQPEQKMLREAHGSL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8 in vitro.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Domain:
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Sequence:
MYQIFFFFLPLLHSYASAQTPPPFRNGDLVANFEPSLAVVTGVLAIMFALTFVLLVYAKCCHIDLRSGSGDRRRHDRRLRQGIFFNRSTASSDRFSGLDKTAIESLPLFRFSALKGSKQGLDCSVCLSKFESVEILRLLPKCRHAFHIGCIDQWLEQHATCPLCRDRVSMEEDSSVLTNGNSFRFLNQSEIREDSSLELYIEREEEEERIHREELSGSSRFSIGESFRKILKLGNKEKTLLDEHVNDKDEKKLMHKFNHRIVVSDVVFKNRWSNVSSSDLMFLNSEMVNSISSERFSSLDHVKRGDEEDQIGILRIKEEMEAKRMLENKLTSMTTMFSSENGDSGSKSRSVMIEPGRRSVSDITAVPRLSISIHGDCSGSAAETASALQNGGNETEERRRRLWLPIARKTAQWFANREKRSQINTTHQHFDV
The following text describes a protein:
Function:
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. The pyruvate dehydrogenase complex contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Miscellaneous:
MISCELLANEOUS: The active site is a redox-active disulfide bond.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MAMANLARRKGYSLLSSETLRYSFSLRSRAFASGSDENDVVIIGGGPGGYVAAIKAAQLGFKTTCIEKRGALGGTCLNVGCIPSKALLHSSHMYHEAKHSFANHGVKVSNVEIDLAAMMGQKDKAVSNLTRGIEGLFKKNKVTYVKGYGKFVSPSEISVDTIEGENTVVKGKHIIIATGSDVKSLPGVTIDEKKIVSSTGALALSEIPKKLVVIGAGYIGLEMGSVWGRIGSEVTVVEFASEIVPTMDAEIRKQFQRSLEKQGMKFKLKTKVVGVDTSGDGVKLTVEPSAGGEQTIIEADVVLVSAGRTPFTSGLNLDKIGVETDKLGRILVNERFSTNVSGVYAIGDVIPGPMLAHKAEEDGVACVEYLAGKVGHVDYDKVPGVVYTNPEVASVGKTEEQVKETGVEYRVGKFPFMANSRAKAIDNAEGLVKIIAEKETDKILGVHIMAPNAGELIHEAAIALQYDASSEDIARVCHAHPTMSEAIKEAAMATYDKPIHI
The following text describes a protein:
Function:
Hyaluronidase catalyzes the hydrolysis of hyaluronic acid (HA), an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. In venom, they are known to enhance diffusion of the venom by degrading the extracellular matrix (Probable).
Subcellular Localization:
Secreted.
Sequence:
MRVVVVVTGLVVVVVATALSLPDHDVKSASSPLSSSSVYQGSSGDDCDEGLPPPDRPFYVVWNHPDTCKRNRIPLHLDHYGFIFNKNRLFLGEEIQTLYNTGLWPNISETGEFFNGGLPQLFTHHDYSETVEILGRYRTENFTGLGILDFEEWRAIYDTNFGIMRKYQDESIKLAKQRYPSYNKKELTMVAEQEWDQAAREIMSTKLAIGQALMPGGHWGYYGYPRTWGSKRNTQLRNNRIDWLWRQSTGLYPSIYIKDPNMTESAIAEFVSGNVEEAVRVQDEFSPPNTPIYPYAMLQSGDHIFFQVDHLKISLGLPAKMGTSGVILWASSNRYKNATRQCSRMRVHIDNVLGPYVENLTQVMADCSTTLCGGHGRCVHNSHDVLLGETDSQRLSGLCTPRHSRFRDYHCRCYSDWEGACCQTVRPSRCHKQQQGNVHEGGDLQEGHVVNVVNPLIG
The following text describes a protein:
Function:
Binds to orexin receptor HCRTR2/OX2R only. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner; Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner.
Subcellular Localization:
Cytoplasmic vesicle. Rough endoplasmic reticulum. Synapse.
Sequence:
MDCTAKKLQVLVFMALLAHLARDAEGVASCCARAPGSCKLYEMLCRAGRRNDSSVARHLVHLNNDAAVGILTLGKRKVGESRVHDRLQQLLHNSRNQAAGILTMGKRLEEPAKFLIPTVPQDVDSYEKR
The following text describes a protein:
Function:
Odorant receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
CCFHRKGSQEMLELTSNYTSPSITFFLIGIPGLEVTHLWLLVPLSTMYIVALVGNSLILTVIWVDSALHEPMYYFLCILALVDIVMATSVVPKMLNIFWSGDGIIGFAACFTQMYVVHAATAVETGLLLAMAFDRYVAICKPLHYQTILTQQTMLGISVAIILRATTFMTPLSWMVSHLPFCGSLMVPHSYCEHMAVAKLGCADHMPSDLYSLIGSSIIVGIDVIFIATCYSRILQAVFRLSCRDAQLKALSTCGSHVGVMALYYLPGMVSIYVAWFGQDLVPLPVQVLLADFYLVIPPTLNPLIYGLRTKQIRGRGWSILKSCLPDQAN
The following text describes a protein:
Function:
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MASNNKDSQLMIALKDIVAGSIGGVGQVFTGHPLDTIKVRLQTQSVGNPIYSGTMDCLKKTISQEGFAGLYKGVASPLVGLSIMNSVMFLAYGQSKTLIQKLSDNPNEALDLKGLTAAGALAGIAIGFVDAPVDLFKSQMQVQQGDKNQYKSTADCAKQIWKVGGVRGVFQGLGATLVRDIPANACYFGAYELCRDFLASKDNISVNQLSSLQIMAAGGAGGVSYWTLTYPADVVKSTMQTDAIVKSQRKYKNMIDCASKIYKQQGIAGFYKGFTPCFIRSVPANAACFVLYEKARQIMS
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MAGRGSRRRRFRRRKSTIKQGGNGDGDGDAHCPPHPGFVCGAMEEDTEAEGAAPRVPVAPCPSRRVLSFLGLGGTKEEGSAEGGAPSKIRDREGPAAVPASMTTSIPRVSDLETLLRARKLTLILDLDHTLLNSTGLDDLSPAEQANGLTRHTKGDPTAGLFRLGRARFRMLTKLRPFARGFLEQASAMFEMSVYTLGDRGYARAVVKLLDPDGAYFGGRVVSSDESTRRDRKSLDVVPGAEAAAVVILDDSSHVWPEHQENLIVMDRYLYFADSCRTYGCGVSSLAELRRDEREHDGALAVALQVLTRVHQGFFDSVLGGRFSDVREVIRAVRSEVLRGCTVAFSRVIPLEGVAGDHPMWKLAEQLGAVCTADADATVTHVVALDPGTDKARWARDNCKFLVNPKWIMAASIRWCRPCEQEFPITRRHGR
The following text describes a protein:
Function:
Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSVPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQGPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPPSFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRIDYDRGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREKKRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETTPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLDREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEYAITNDKTKRPVALRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQAEMGAAMDALEKYNFPQMAHQKRFIERKYRQELKEMRWEREHQEREPDETEDVKK
The following text describes a protein:
Function:
Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block by Mg(2+). During the development of neural circuits, participates in the synaptic refinement period, restricting spine maturation and growth (By similarity). Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits (By similarity). Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits (By similarity). GluN3A subunit also binds D-serine (By similarity). Each GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (By similarity). By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane. Postsynaptic density. Note=Requires the presence of GRIN1 to be targeted at the plasma membrane (By similarity).
Sequence:
MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAQDGGRAGAQRDEPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGTETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESIINITANLSSTKDLLSFLQVQLENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPDLHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPCSKTKRVEKSRWRRWTCKTEGDSELSLFPRSNMGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQTHQDIPLPPRRRELPASLTTNGKADSLNVARNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTNRTCES
The following text describes a protein:
Function:
Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.
Sequence:
MNRATRSVLHGLTAPHRHSSPRTPHIFTKRNYLLSGDDSLNQSTTTINARTEPTITSEHPNSNAFKIWPTITSQPPREIIKPEKRSRIYIDTENTSVALREALLSSELKKAWTAYRLLPASECLLLTHEDHSTLLGLLTAHTHSTIAEAHSVTVIFRMREHDIHLDIRDYHNLMRIYLANNNEAKMLDAMKTMQKVDGVQPDLICYNLLMALYAKSIPRRLDMLTNTWIESLRQMPWARLANMDGWAILIDGYARGGDVEGAEKMYEHVKSKAESAGMEIPAHVHEAAIRMYGLAGKLTDASRVFDFVLRREGPSTQSKTVGSAYQGVNEHLYDAMIEACQACNNLGLATMYFKQVMDMCDQWDEWWTASYLNRHSLITRGVLSLPIKLTPVYDRFKRRDGSNFISDNENRGHLCLLMELYQNQSKENFPRNRAYPLSITFDRMICLAAQANDSRLAFEYLCMHIAHNKPEDISFEYVIRMYIRMGNIDAAHQVYRAMAYFGFRPSVEIAAAITSYGPLDPNAPTTF
The following text describes a protein:
Function:
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MRGDGIRARKALGQNFLTDRSVLSRIAALVSAGAGERILEIGPGKGALTSYLAEQAGQLVAVELDDRLVPLLRGSFAGNPSVTIIEGDILDLDLRETLGRYGTPPWKVAANLPYNISTPVLFRLLDARDLFSRLVLMLQKEVGNRLAAGPGSKEYGVLSVLFQLHFDVTREILVRPGSFHPVPKVDSVVLLFVPLAQPRVDVGDEDYFRRVVKASFAMRRKTLWNCLKGGALGVPTDGIRDVLARCGIDEGRRGETLSLQEFASLTKGLLAAGGSL
The following text describes a protein:
Function:
Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space (Probable). Determines the precise timing of host cell lysis. Participates with the endolysin protein in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell.
Subcellular Localization:
Host cell inner membrane; Multi-pass membrane protein.
Domain:
The first transmembrane region undergoes a helix to beta-hairpin conformational change, which is responsible for its self-association and pore formation in the host membrane. The coiled coil region is required for host cell lysis and for cytotoxic activity. The C-terminus determines the size of the hole.
Sequence:
MSPKIRETLYYVGTLVPGILGIALIWGGIDAGAAANIGDIVAGALNLVGAAAPATAAVKVNQQRKDGTLTTSPVDQVTRGVEQVLAAKQNAEAEVERVKQALESAVNGAVPQLGPLASQILNGIQPAYSQPFDPHTQPWNR
The following text describes a protein:
Function:
Segmentation polarity protein. Acts as a receptor for the hedgehog protein (hh). Associates with the smoothened protein (SMO) to transduce the hedgehog signal leading to the activation of wingless, decapentaplegic and patched itself. Participates in cell interactions that establish pattern within the segment and the imaginal disks during development. In the absence of HH, represses the constitutive signaling activity of smo through fused (FU).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDRDSLPRVPDTHGDVVDEKLFSDLYIRTSWVDAQVALDQIDKGKARGSRTAIYLRSVFQSHLETLGSSVQKHAGKVLFVAILVLSTFCVGLKSAQIHSKVHQLWIQEGGRLEAELAYTQKTIGEDESATHQLLIQTTHDPNASVLHPQALLAHLEVLVKATAVKVHLYDTEWGLRDMCNMPSTPSFEGIYYIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVVIPGLNQRLLWTTLNPASVMQYMKQKMSEEKISFDFETVEQYMKRAAIGSGYMEKPCLNPLNPNCPDTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLGWTQEKAAEVLNAWQRNFSREVEQLLRKQSRIATNYDIYVFSSAALDDILAKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGVDHIFMLTAAYAESNRREQTKLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMISLDLRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQNPLLEQRADIPGSSHSLASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDFWLLLFSEWLGNLQKIFDEEYRDGRLTKECWFPNASSDAILAYKLIVQTGHVDNPVDKELVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYDLKIPKSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLRSSLAMILACVLLAALVLVSLLLLSVWAAVLVILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGFMTSVGNRQRRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSMVGPEAELVPLEHPDRISTPSPLPVRSSKRSGKSYVVQGSRSSRGSCQKSHHHHHKDLNDPSLTTITEEPQSWKSSNSSIQMPNDWTYQPREQRPASYAAPPPAYHKAAAQQHHQHQGPPTTPPPPFPTAYPPELQSIVVQPEVTVETTHSDSNTTKVTATANIKVELAMPGRAVRSYNFTS
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
Subcellular Localization:
Mitochondrion membrane.
Sequence:
MAFGDYPAEYNPKVHGPYDPARFYGKADVPFGQVKLGEIGAWLGRRNKTPNAVAGAVSRAWWRWQHKYVFPKRAGIAPFFQLTVASMTFFYLINYTKLKHHRNYKYH
The following text describes a protein:
Function:
Required for spore wall assembly and ascus formation.
Subcellular Localization:
Cytoplasm. Note=Diffuse location throughout the cell at all stages of sporulation.
Sequence:
MFRRGDNSNFNVQNSFFLPLEYEYTVKDNVPSKKKSSIGFFPLDDSLFTSKNNSGHHKSEQLHRGNAETIRSQFGTDAVPIRIDEKEGKWDRIQDDNSSNLNYQINNSNDPASSGKYTQSIDCNHIAESKFSKKNGNIDSLRSNSATFMLNTADEDVIEFSFDDNVPYAELLSGATLEKCSLTLNEINKKLFNTLYDFRVSKDNPEENLVELILPNCVVLLNFFEDIELLADSSDEAFEKSTFINTIEFIVHDIWVETLIKNINLLQMFDADLKCYNDKYIICKLKGQYPSTNIVDIMCRLKHFSNSILETFKFGIELKEQDQCHNRNTIINYVLFSRVFSTIVLEIQKCFILIVKFMYSVNFLEKFSDEVFLSFIEILIKIVFEHQIPQLFLGIDEIIQLWLKNNEGKRQQLLSAWCNGTVQDMKQSQQRESSNAESESITSSTEEDEEGLQFNKWDVIEPFIDNIKALNQSKSHM
The following text describes a protein:
Function:
Shows a cytidine deaminase activity on 2'-deoxycytidine (in vitro), however shows no RNA editing activity (in vitro).
Sequence:
MGLQAGTRQLHGNLILLPVAVVMLLLCTSPVCATASVGLPADCSRLTSSSPSGVYVIQPAQSPPRVVWCDMDTEGKGWTVVQRNTYSTEITWKESWTTYKYGFGNVQGDHWLGTEYLHLLTQQGTYKVRFVVRDKANVTHYAEYDIFRVESESSGYPLRLGRLLSSGKDYLTSYYSSYGGIHDNMKFSTVDKDQDQHSGNCASSYGGWWYDRCQNVLLNGKKYILWPEICPRVTACRPSSWSNPPMCADCARGWGSATIPSRSPSLPSPITATHTVRNQLQ
The following text describes a protein:
Function:
NAD-dependent deacetylase, which plays an important role in the regulation of transcriptional repression (By similarity). May play a role in cell cycle. When overexpressed, the cell cycle is accelerated.
Subcellular Localization:
Nucleus.
Sequence:
MTDDIVFENMVIDDTIVEEEDVEMKYYLKNKKEFEFLAKEMLSGKKILFITGAGLSINSGISAYRNTKTSVWSNFITEWGTRKKFEQDPAQFWNHFWLRTHEKQEYLDALPNSGHLAISNFVEYLGSNVITQNVDALHLKAKVPIEKLVEVHGRISLYKCITKGCRFEYDDTIDNIEIGDYSINGTTMKQGNLEITPPLCPECKKPILPQSLLFDENYSSHQFYNIEKAMDWIQEADIFIFIGTSFSVGITEEVICHAQSERKKMFNFNIFKETKISGLKSIVGKSEITLPLLERQLLYEAQKRNNGKKQIWYGNTIKRIVSENSMLLKEAMLKNDTKSSVKV