lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay. Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs). Also mediates C(5)-methylation of mitochondrial tRNAs. Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay. Cytosine C(5)-methylation of mRNAs also regulates mRNA export. Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity.
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, spindle. Secreted, extracellular exosome.
Sequence:
MGRRNRRNRQRHQRSTEQRSPAEEEQRRKAREQAAWECGYPEIIKENKLFEHYYQELKIVPDGEWDKFMASLREPLPATIRITGYKSHAKEILHCLKEKYFKELQDIEVDGQKIEAPQPLSWYPEELAWHTNLSRKIIRKSPELEKFHQFLVNETESGNISRQEAVSMIPPVLLKVQPHHKILDMCAAPGSKTAQIIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDASSIPRLLVENNGSREVLYYDRILCDVPCSGDGTLRKNIDVWKKWTTLNSLQLHGLQIRIATRGVEQLAEGGRMVYSTCSLNPVEDEAVIASLLDKSEGSLELADVASEIPGLKWMPGITQWKVMTKEGHWYEKWEDIPTSRHTQIRPTMFPPKDEEKLKSMNLNRCMRILPHHQNTGGFFVAVLIKKAPMPWNKRQPKLQRRPPVSACDASIAVAPELVKAVTENSAGMADEPAVDTENGETKPCTNQSDSSKTDIVCCPPPSKKMKLFGFKEDPFVFVSEDDPIFDPIQTFYALDPSFPKKNLLTRTQEGKKRQLYMVSKELRNVLLHNSEKMKVINTGIKVLCRNNDGEQYGCAYRLAQEGIYTLYPFINARIVTVSIEDIKVLLTQENPFLSKFSKETQKQANNFDMGSIVLKYEPDPQEPETLQCPIVLCGWRGKTSIRSFVPKNERLHYLRMMGVEVFKEKAEVLEKKPVEGKACDEEHIDEKMDIDGAKEESKELSGNESGDDEDPKEEDVIDRGVLEHVALKNTSAIPASVEDQAEDASVSKESVD
The following text describes a protein:
Function:
Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans.
Subcellular Localization:
Lysosome membrane; Peripheral membrane protein. Secreted.
Sequence:
MEIGEDMVADGMDKEWKRGKIAQQGKGTEESRMVVEMVISPSQGREPELWRMKEERVCRLSIERVQARYSSRVNSFFIILGVFIGKGHVQYDVDVLYLSSSRHYRAHKKDVFNGMRMSGATPIAETDDNFVCATLDLWPTEKCNYNQCPWGKAGILNLDLKKKGLINAIKAFNPLRIKIGGSLQVQVVYGVGGVKNCPNFMKNEDSLFGFSQGCLPMERWDELNNFFNQTGVKVTFGLNALLGRNRSEIEKGLWVGDWQSQNAGDCMKYTISMGYKVDSYEFGNQLSGAGMGASVEAEQYGKDIVVLKNLVKELHPDPKTQPKVLGPSGYYDEKWFNSFLEVSGHDVVDGVTHHIYNFVPGDDPNMIAKIQDPSYLNQVSQIDKGVLNIVNKFKPQSGAWVSESGGALHGGAKDLSPTFADGFWYLDQLEMASTYNQKVFCRQTLIGGNYALLNTTTSIPNPDYYGALLWHRLMGSTVRAVTQESNPNLRVYAHCAKKKPGISIIFINLSKDSSFNFTLSNYEHQGRNLRSTDVVKPKFEFRGSKDREEYHLAALAGNIQGQIVLLNDVPMVPTETFDIPAVEPKLVNASTPIHITAHSIVYVTIRDFQAPACA
The following text describes a protein:
Function:
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
Sequence:
MTTQVPPSALLPLNPEQLARLQAATTDLTPTQLAWVSGYFWGVLNQQPAALAATPAPAAEMPGITIISASQTGNARRVAEALRDDLLAAKLNVKLVNAGDYKFKQIASEKLLIVVTSTQGEGEPPEEAVALHKFLFSKKAPKLENTAFAVFSLGDSSYEFFCQSGKDFDSKLAELGGERLLDRVDADVEYQAAASEWRARVVDALKSRAPVAAPSQSVATGAVNEIHTSPYSKDAPLVASLSVNQKITGRNSEKDVRHIEIDLGDSGMRYQPGDALGVWYQNDPALVKELVELLWLKGDEPVTVEGKTLPLNEALQWHFELTVNTANIVENYATLTRSETLLPLVGDKAKLQHYAATTPIVDMVRFSPAQLDAEALINLLRPLTPRLYSIASSQAEVENEVHVTVGVVRYDVEGRARAGGASSFLADRVEEEGEVRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRAFMQQRAADEAPGKNWLFFGNPHFTEDFLYQVEWQRYVKDGVLTRIDLAWSRDQKEKVYVQDKLREQGAELWRWINDGAHIYVCGDANRMAKDVEQALLEVIAEFGGMDTEAADEFLSELRVERRYQRDVY
The following text describes a protein:
Function:
Methyltransferase which catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
Subcellular Localization:
Cytoplasm.
Sequence:
MAQRVQEEDEQMMSTDDLIQAQIKLYHHCFAFIKSTALWAAIDLRIADVIHRNGGAATLSDLALNVGLHPTKLSHLRRLMRVLTVTGIFAVEDRNGEAMYTLTRVSRLLLNSDGEGTHALSQMARVLANPLAVISHFSIHEWFTTEKATTMTPFEVAHGCTRWEMIANDAKDGSVFNAGMVEDSRVAMDIILKESCGIFQGISSLIDVGGGHGAAAAAIATAFPNIKCTVLDLPHIVAEAPATHSNIQFIGGDLFKFIPAADVVLLKCLLHCWQDDDCVKILRLCKEAIPARDAGGKVIIIEVVVGIGSEEIVPKEMQLLFDVFMMYIDGIEREEYEWKKIFLEAGFSDYKITPVLGARSIIEVYP
The following text describes a protein:
Function:
Converts sphingomyelin to ceramide.
Subcellular Localization:
Secreted.
Sequence:
MACRRSTFLVLLCSFWCYLGLTNSSPIPSMRHEQLLEKETRTYFAHRIAPLLFAYSNASLSQSPPLLDPTYMNNIIHESASTYHLDIDCDLCKDIMAAIDDVIMSEESRDLIAVIAAEVCKILKIEDDRVCDYITREFKDEVVDVAALHYLSPNQVCGTLLGESCAVTYDPNSDWNVTFPSIPKPPVTPVNPPKQGSPTLRILHISDLHIDRMYEPGTNTDCGEPICCRSNDGPPAPGVPGAGKWGDLRGCDASLKLMINTLEEISKTQKLDLIYMTGDLPAHDVWNQTRSDNLGIFNLVTDLLLKYFPGVKVYGALGNHESAPVNSFPPTDVIKGDQSETWLYNNMVDSWIDKADWLPNTTRATIQRGGYYDVLLYPGLRVVSLNSNAGNPKNWWLRINGTDPDGQLQWLIGVLQAAEATGEKVHILGHIPPSSTLPVWSKNYELIVKRYESTIRGQFFGHTHHDQFHLFYENVTTRRPINVVYVAGAITPDTQFPGYRVYTLDGSYANSTWAVLDHDNYYLNLTEANLTDKPIWRHEYTAKQTYNMTSLQPEEWNRVVGQMKTNTTLFNQFYRLYHRQFDAGPCDATCRASLICNIETSRADDSSYC
The following text describes a protein:
Function:
Transporter for myo-inositol.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAILISDVFFTIGAVLIASSYSVPQMIVGRIILGIGVGGAAVIAPLFITETAPTAVRGRCIGVNAFFIPFGQVVADAIGAGVQNVHNGWRLLFALGVVPSVLQLLLFHYLPESPRILILKGDTDRARTVFQSIYPTATRDMIDYKFRVAQEYVAATTALQSETTFWERVKKVWKTGSYRRSITTVSVLQAAGQLCGFNTLLYYAGTLFGLLGLSNPALGGLIPAGTNAVFVLIGMSLVDKVGRRGLMLFGVPIMLLGLVWNIIGFYYLCKPTGGFLDTSYSYDTTNVGVVIGGIVFFVVGYGLTYSHLVWYQAEYLALEVRSMGSGVATTVCWIANLVVSVSYLSELETMTPSGTYGFYLGLSVIGFAFVVFCFPETKQLSIDETSLLFENDWGVKRSVQMRKERRETRKRFQDAELAEAATAHLEARQQKSTSVSPAELSKFMAGLKGNKRKPSVLVKTAT
The following text describes a protein:
Function:
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Sequence:
MRRLGFSLAFFEDDYGVYCNFSSLSRTAAKYVSPLSHGVCLSARKGEYRRAVIFDRCRCCVVKTTFSSSGIKSFSLSHNRTIPYLTHFVSFVSRREGFPTLLSLSSWRLSRSSCGSRWELYCLEHGIKPDDMMPSDSTFDVAHDAFKTFSETRSGKHVPRAVFVDLELTVIDEVHCGTYRQLFHPEKLISSKEDAASNFASVGKEIIDLCLDHIRKLVDNCTGLQGFLVFNAVDGGKYPRIHFMLSSYAPIISAAKFYHEQLWVPKITNAVFKPASMMAKCDPRHGKYMACCLMYRGDVVPKDVNTVVATIKTKRTV
The following text describes a protein:
Function:
Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity).
Sequence:
MAKNKVLGRGLADIFPEINEVYEQGLYERANRVVELGIDEVMPNPYQPRKVFSEDSLEELAQSIKEHGLLQPVLVVSENGRYHLIAGERRLRASKLAKMPTIKAIVVDIEQEKMREVALIENIQREDLNPLELARSYKELLESYQMTQEELSKIVKKSRAHVANIMRLLTLSSKVQNALLEEKITSGHAKVLVGLDGEKQELILNSIIGQKLSVRQTEDLARDFKINANFDNKKHGFKQTQTLIAGDELERLNQSLWDHYKLKAALKGNKIVLRCYENSLLEAFMKKMMS
The following text describes a protein:
Function:
Displays both high peroxidase and manganese peroxidase activity. Is likely involved in lignin degradation. Also has a Mn-dependent oxidase mode of action that expands its substrate scope in vitro; is thus able to catalyze the O(2)- and Mn-dependent oxidative decarboxylation of 4-methoxymandelate to anisaldehyde.
Subcellular Localization:
Secreted. Note=Although no signal sequence is found, the secretory machinery for actinomycetes is not fully characterized, and the low pH optimum for DyP2 along with the observation that many DyPs have been isolated from the secreted protein fraction imply that DyP2 could be secreted and still possibly play a role in extracellular oxidation chemistry.
Sequence:
MPVDLSTTLSWKSATGEAATMLDELQPNILKAHVRDRLTVLFLGFGDAAEARTFLNGLSGLMKSARTHLQEVEAHKLTKAVGTPYLGVGLTAHGYATLGVTAPADPSFTAGAKAAVEKLADPAVTEWEGHYQQTIDAVLLLGDATAGPVRTLRRQVEALRPASVTVVGEESGLGLANANGDGIEHFGYVDGRSQPLFLTEDVDAERDTTDGVNDWDPSAPLEQVLVPDPAAPDPTVHFGSYFVFRKLEQNVRLFKEAERDLAHDLGLRGEDRERAGAMLVGRFEDGTPLTAQSAPGSHHPVGNDFSYDSDKLGQKCPFHAHIRKTNPRGSGGAEAPEEERKHLMARRGQTYGRRHDDPNADLPPRLRPAKDVGLLFMAFNSNLGNQFEFTQQIWANNPAFPFPPDGSQPGLDPVIGQGARAPQKYAPEWGHNNVAEATDPIPQAVTMKGGEYFFMPSLAFLRSL
The following text describes a protein:
Function:
TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
Subcellular Localization:
Nucleus.
Sequence:
MSDLFTTFDSNGVAEHHLHHNHNSTSSASGLLHDPPMASPSQHSPMTNNSNSSSQNGGPVSGLGTGTGPISGGSKSSNHTSSAAGSENTPMLTKPRLTELVREVDTTTQLDEDVEELLLQIIDDFVEDTVKSTSAFAKHRKSNKIEVRDVQLHFERKYNMWIPGFGTDELRPYKRAAVTEAHKQRLALIRKTIKKY
The following text describes a protein:
Function:
Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
Subcellular Localization:
Cell inner membrane.
Sequence:
MYDFVIIGGGIIGMSTAMQLIDVYPDARIALLEKESAPACHQTGHNSGVIHAGVYYTPGSLKAQFCLAGNRATKAFCDQNGIRYDNCGKMLVATSDLEMERMRALWERTAANGIEREWLNADELREREPNITGLGGIFVPSSGIVSYRDVTAAMAKIFQSRGGEIIYNAEVSGLNEHKNGVVIRTRQGGEYEASTLISCSGLMADRLVKMLGLEPGFIICPFRGEYFRLAPEHNQIVNHLIYPIPDPAMPFLGVHLTRMIDGSVTVGPNAVLAFKREGYRKRDFSFSDTLEILGSSGIRRVLQNHLRSGLGEMKNSLCKSGYLRLVQKYCPRLSLSDLQPWPAGVRAQAVSPDGKLIDDFLFVTTPRTIHTCNAPSPAATSAIPIGAHIVSKVQTLLASQSNPGRTLRAARSVDALHAAFNQ
The following text describes a protein:
Function:
Involved in sequestration of excess zinc in the cytoplasm into vacuoles to maintain zinc homeostasis.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Sequence:
MDSRRSKVCGETACGFSTSSSDAKKRAASMRKLCFVVVLCLLFMSIEVVCGIKANSLAILADAAHLLTDVGAFAISMLSLWASSWEANPRQSYGFFRIEILGTLVSIQLIWLLTGILVYEAVTRLVQETNDDVDGFFMVLVAAFGLVVNIIMIVVLGHDHGHGHDHGHSHDHGHSYGERAEQLLEKSKEIRNINVQGAYLHVLGDLIQSIGVMIGGGMIWYNPKWKVIDLICTLFFSVIVLGTTIKMLRSILEVLMESTPREIDARQLEKGLMEIEEVVDVHELHIWAITVGKALFSCHVKVRPEAGDEMVLNKVIDYIWREYRISHVTIQIER
The following text describes a protein:
Function:
Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.
Sequence:
MIGLLIVSHSARLAEGVQEFVGQISGGQIPIIAAGGASDGSLGTSVERILAGLEQLRTTDGILALVDLGSAVMSVETALEHFSGPPVHISNAPLVEGAYLAAIEATSATATLEHVASAALQARDLIKVYE
The following text describes a protein:
Function:
Required for nuclear membrane fusion during karyogamy.
Subcellular Localization:
Endoplasmic reticulum membrane. Nucleus membrane.
Sequence:
MQYWLMIAFVCLLLQADGCFASSLKAQLSVAPKAEGLMEFDSIIQVFQTLSRKPTCHQSVIYSLMAQCELQNSVLSMDERIQFSTRLTMCDLEHADITVPSECLRGSQQKCLATLEDNSAWWLAFVSYYRDMDRLCKSAFLEYEKQNALELNKNITRIQKRLLEVLQEKLTEQEISLELMQDTTATSVKRLEQIITSSQSSVIMDMEQQTAQLQKLQNSFDLLTQYQSEVLDSEAFASNKLELLRENVNGLLSAYSSQMNALANIANRGLQSLADEVSKHQTNLQESAVQDAKIFANEVVHTYRNSMAQTKNDLMNFMKSQQSLTEFYFGTTCRME
The following text describes a protein:
Function:
Mannose-specific lectin which binds alpha-D-linked mannose. Displays a high affinity for alpha-(1-3)-mannose oligomers. Displays antiviral activity and therefore may contribute to defense against infections.
Miscellaneous:
MISCELLANEOUS: Inhibits the attachment of HIV viruses to susceptible cells. Has a significant inhibitory effect against various viruses including HIV-1 (IC(50)=0.4 ug/ml), HIV-2 (IC(50)=0.3 ug/ml), and SIV (IC(50)=0.8 ug/ml) in MT-4 cells. Also inhibits human CMV replication in HEL cells (IC(50)=0.9 to 1.6 ug/ml) and inhibits syncytium formation between HUT-78/HIV-1 and MOLT-4 cells (IC(50)=2.7 ug/ml), and HUT-78/HIV-2 and MOLT-4 cells (IC(50)=3 ug/ml).
Subcellular Localization:
Secreted.
Sequence:
MAKASLLILAAIFLGVITPSCLSDNILYSGETLSTGEFLNYGSFVFIMQEDCNLVLYDVDKPIWATNTGGLSRSCFLSMQTDGNLVVYNPSNKPIWASNTGGQNGNYVCILQKDRNVVIYGTDRWATGTHTGLVGIPASPPSEKYPTAGKIKLVTAK
The following text describes a protein:
Function:
Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity).
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein.
Sequence:
MTIPHEVLAQGWIPFTVVVVLAILFSWFYIRYYQDHSQSEVSSTITGIIALFIALMTTALVPVDIFLVSYMKNDDGSWKPWSANRMNRDDIEETAVATTYYILYALLAFFVFVIIPFMYFFFEERDEDITTAERACGALKYSIGFLIVASVLLLVGAFAPLKQPPKNVTEWDKRLIFLKDELKSNNGETALSLLIGFLTLIGMLIMITYTAYGMTALPFSLLKGFKSAKTEQESVTRRRSRNQEQARLIKAQYMGGRAMSSRDRRRLSELEKEEHALATRERRLEAAQLGWLNKCLKLLRPFEMVFGAFFLLVALLIFVSLFITCLDKALHSNGYQYGYSLPTPQLPNPINIIMVYAQIVFPLDYCLFLLVVLYFVYSSMAGIRRVGIRCCWIKLFKVRPRRTLPQALLFMCVMLMLIVLSLNVMLFSLAPQYVMYGSQNYRANSTVTSLVNHTGIIQNVTTSHGIAKVCSMEMSSDHCTMTRIAVFLNRFFYKVWFFGACYYWGTWLFLVVFMTGLIYSIVRKRKTVVDEEYDSSDDSDEEMVTA
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MMLRKLLEQDKTEAASAIADDKISQNKQEQDDEILALEAIYEGSFKHLSKESDGDLRCFMIEVTLEAFESIEISMERPLPSSGATNRHSFTLQYLPPIHLAFLLPSTYPSHSRPPFVLHAQWLSADRLIRLSDKLLEIWEDQKGEVVVYPWTEFLHSQALSAIGAFEKLELVQQPLKLHDPRVISGCNSLDEDALSLLRYNEEMQLSTFLSSIHLCTICFEESTGREFIKLPCQHAYCRKCMQQYMSVHVTDGSINSLKCPDCKGGIPPSALKELLSEEDFERWEKLCLQKTLDAMSDIVYCPRCGAACIEEGDHDAQCSRCFFSFCSLCRAARHDRGSLSEDQRKREENLVNELKNLDFVKKDAKPCPTCGMAISKSAGCNKMTCSNCGQYFCFKCGKRIDGYLHFSNSCTLFDDDDRGENAQLWQLVQQQEQRQQQRQEAIRFGKPCPSCGQPNVKVGNNNHIFCMSCQNHYCGQCHKLVRKSSEHFGPNKCKQHSVEPR
The following text describes a protein:
Function:
May play an active role in the motor area of the primate neocortex.
Subcellular Localization:
Secreted.
Sequence:
MDLSAAAALCLWLLSACRPRDGLEAAAVLRAAGAGPAGSPGGGGGGRRTLAAAAGASAAPAAAAPGPRAARRAAGSGFRNGSVVPHQFMMSLYRSLAGRAPTGAVAASTSGAGRHGRADTITGFADQATQDESAAETGQRFLFDVSSLPDADEVVGAELRVLRRESPEPGPGRATSPLLLLSTCPGAARAPRLLHSRAAEHLEGARWEVFDVVDAVRRHRWEPRATSAFCLLLRGVVGPGRDPLALRLLGFGSSGGDGAAEEERALLVVSSRTQRKESLFREIRAQARAFGAALAAEPPPDPGPAIGSSTAVIGGRRRRRTALAGARAAQDSGAGGGRGHGRRSRSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGVCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR
The following text describes a protein:
Function:
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MESNNSRKKLIKKLRKHQHTVGKETGVVCTDSPTKNLVICNTGQINGLTEEIIVEHFEKYGHLDRVLLVPGKSCAFLSYKDTSSASEALEAVSGKLNIAQDGKPIFLSFVEALPEIRDAKIWGRLPPGLRIITNFVSEEEEARLLALCQFEDGGSMKHRLVKHYGYEFRYDINNVDKEKPLSEGIPQECDFLWRRLPFEFRPNQLTINRYNPGQGIPSHVDTHSAFGDPILSLSLSSDVVMEFKKDETICVLLPRRSLLVMAGESRYEWTHGIVPRTFDFYNDEGGCHCFKRGVRVSFTFRKIRKGGCNCSYKLQCDSQTATKIIESDLLAHKLENQHVHDVYEDIAGHFSETRHTPWPNVLNFVQKLEIGAVLVDVGCGNGKYFGHNRQIVELGTDRSFKLNNLCKHRGFEVFTGNCLNLPLKNSSADAVISIAVIHHLSTPERRLKALKEIVRILRIGGEALIYVWAKQQIKNDEKSTYIKQDRKNRKKEVIGSVTKEEVSVGEGVTLPVHTNRANFTHSDVLVPWKLKGEEQERTFLRFYHVFEEGELESLCQSIGNVSIVKSYYDQGNYCVQFVKNNK
The following text describes a protein:
Function:
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of the anamorsin/DRE2 homolog, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MSIAILYGSETGTAQDIAESLRREAQQRHLQARVHELDEYDVSQLPMEKVVLFVVSTTGQGEMPPNMRKTWKLLLRKSLGADFLKNVNIGVLGLGDSSYQKYNFAGKKLYRRLVQLGAKMMCGVHLADDQHEIGIDGAFIPWKTECWKKIKEIAENLSIYREMTAEIDTSVQITTKYRFLELGGESGNDDDDSDEDLEPQIEIPDYFPLKVLKNRRLTSAEHFQDTRLVDFEISDRNRSKMGFQPGDVLMVRPYNPEETVKIAIEALGLTEEQLKKPLKIVKNDRFSKNPPNFLVGNFSAKTTLLTCLQRYFDLQQVPKRSFFEMLGYYSTNPPEKERLQELASPEGLDDYLDYANRSRRTTAEALRDFVATSKNLKPDYLFEILTTIRPRAFSIASAPSPFHLELLVAKVEYKSRMADKRRGLCSTFISRLKPGDEVFCKIRPGTFKFPSPEAPVICIGPGTGVAPFRSLFGHRSLFSAHFPGILFFGCRSEHHDYYFSDEWPELSGVAVIPAFSRDTDGRKVYVQHKMGENAGKIKRMLDLGAQVFIAGSSGDMPKAVSAVLAQIQGDEWTRRAEETGKIQYETWS
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins.
Sequence:
MKKSIDVFDFNEEDEELAESASGKLLEKFANPSSSVSPILQCQRIQSFCQEEPAPKEVEGASCAEAATDVVDRHCEDAPALATEAEESSRDHFTESDVNHGLVFGLNTEDHRAKEADVDDDDHGLMFGFDTEDHMKETDEDHGLESFSCQPSAKSFYAETSSYSQPQLNSPFSDSSSSPERTDMMSAIDESLSDRSALSEASDSEGDEDWMAEHCFDDMEKIDRNTAVIMIPEYVVLKDMPCAASLVIFSCNGIKIKSYPDNNGEGPFCCEFGVEDIVSIQYNWYQNVGLIILRIRVLLKDEKCHEDLQHTTDIEELKFAVKDHNWPEKQQQINSLHVKYPAVWSADLDEDVEVSGDNLHRRKRYFPRFDEPFEDVVYPKGDPDAVSVCKRDVELLQPETFVNDTIIDFYINYLKNQIQAEERQRFHFFNSFFFRKLADLDKDPSSIADGRAAFLRVRKWTRKVDMFGKDYIFVPVNFSLHWSLIIICHPGEVANGTDLDSDDSPKVPCILHMDSIKGSHAGLKNLVQSYLCEEWKERHKETSDDISSRFMNLRFVSLELPQQENSFDCGLFLLHYLELFLAEAPQNFSPFKIYNASNFLYLNWFPPAEASLKRTLIEKLIFELLENRSREVINEQDQSCESPVPVNNNTGIEVLSGRCTPLIDCNGNMTQTQDEQGIEMTLLERSSMRNLQAVNDSGMVLRDLFDAGANNTGSLLGQLQQTFDEPSSFYHLSNNSLATEQVEMESGEQFMCLNSGEGGNFQRITGTASPRASASFSSLNLSMMPVQKEGVADSLSNDSEDIGIIEDIPMENINEGETGESPSRETVSLFSATLGPITDHNTENEDLPSTPDELVVASSQDGRDEEKQLENDLGIGDKTNEDLEDKTDKTNEAPGIGGKTNEALGIEDKTRDDLGTEDKTNLKTEEKTSDAFGIEEKKSEDLGDDCDQKEKELTEDEEEKRAAKRPRLSSTGEAEEMEIN
The following text describes a protein:
Function:
Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MSTERTSWTSLSTIQKIALGLGIPASATVAYILYRRYRESREERLTFVGEDDIEIEMRVPQEAVKLIIGRQGTNIKQLRKQTGARIDVDTEDVGDERVLLISGFPVQVCKAKAAIHQILTENTPVSEQLSVPQRSVGRIIGRGGETIRSICKASGAKITCDKESEGTLLLSRLIKISGTQKEVAAAKHLILEKVSEDEELRKRIAHSAETRVPRKQPISVRREEVTESGGAGEPALWKNTGTGTEPEPATTPLGAPSQKGGGDMAGVGPEGAWEKPNGDNFQKSGVQTSPEMSMFEIPSPDFSFHADEFLEVYVSASEHPNHFWIQIIGSRSLQLDKLVSEMTQHYENSLPEDLTVHVGDIVAAPLPTNGSWYRARVLGTLENGNLDLYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLARIAPSGEQWEEEALDEFDRLTHCADWKPLMAKISSYVQTGISTWPKIYLYDTSNGKKLDIGLELVRKGYAVELPEDMEETRAVPDMLHDVATETDVSLGSMLTEPKKSPGEIANTLSCLSLSEAASMSGDDNLEDDYLL
The following text describes a protein:
Function:
Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. VLCFAs serve for instance as precursors for ceramide and sphingolipids. Required for normal biogenesis of piecemeal microautophagy of the nucleus (PMN) bleps and vesicles during nutrient stress.
Miscellaneous:
MISCELLANEOUS: Present with 23600 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Accumulates at nucleus-vacuole (NV) junctions. Sequestred to NV junctions by NVJ1. Accumulates in nuclear PMN bleps and vesicles during stationary phase and nitrogen starvation.
Sequence:
MPITIKSRSKGLRDTEIDLSKKPTLDDVLKKISANNHNISKYRIRLTYKKESKQVPVISESFFQEEADDSMEFFIKDLGPQISWRLVFFCEYLGPVLVHSLFYYLSTIPTVVDRWHSASSDYNPFLNRVAYFLILGHYGKRLFETLFVHQFSLATMPIFNLFKNCFHYWVLSGLISFGYFGYGFPFGNAKLFKYYSYLKLDDLSTLIGLFVLSELWNFYCHIKLRLWGDYQKKHGNAKIRVPLNQGIFNLFVAPNYTFEVWSWIWFTFVFKFNLFAVLFLTVSTAQMYAWAQKKNKKYHTRRAFLIPFVF
The following text describes a protein:
Function:
Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons.
Subcellular Localization:
Chromosome. Cytoplasm, cytosol. Nucleus membrane; Peripheral membrane protein. Note=At 36 hours after oviposition, detected in the nucleus and the cytosol where it is associated with chromosomes and to the surface of the nuclear membrane. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Sequence:
MASDYYQVEILHYLNPNLIWVEVLNSPNEISFEQLGVYGILPIDASLDVERPGLKLQRSEDWMPATAILMKNIFQNLEQVWFSPTHIDRRSSIFDNNIHKYGELIIKKNGVQLYLSKELVKAGLATEDPCQFHQYMSLGKIKTKLSNTETRAVIKNLEEYYRKSSKPKELWQKSVHQNTSIFHAGERLQALTVKNLERHNNRQNIMLLENKLKDLEQCKGSDEVSLGRGVCRVPSNKSEMVMLTNKRLKNRLELLSKINMKSDATDAVKSTKRNFSGDGQRKNFENDFESDDESVKKVSIANTINTSDGSANVVDKLLDEKQIDNVFNNKKQICYTESTRRNPVKKAACIVYGPPSINIDKLPLKEAPKMTKTVKWTPHVDCDKEASEVSFGDVDSHVKLDVKNLDKFHEIADRIEIEKTIPVDVNIHKDLYDSMINNKNESESKIMETANLKTEMKNLRKSSILQSKLKQFDKFNVSSNSAASESSTKSSMDSSRISDEDDLSSDDEMSEIMETFKLNLATPKKSEAKHTIDHIEVNNTKLNANPFKNLDGSKSVFVDKLTSPVLLVHTKRNNKVQPCSLLRDVPFGTSIHVVLRNMGIKHPTRLQTVSWGTILRGLSTFLISPPRSGKTMGYLPAVCRLVRDFRKESPDSCGPKCIIVCATSKSVSEVERISKMLLGLEDKVFACYSGMDNLSVTTALLNGCDLLICTPKSIVRLLQNDLSVDLRDLTTFVVDDCERISDVYSNEVKYVLYEIKNMLKNRVNKELKVQIVVASRIWCDFLEPIVLKAPDSVVCIGAFQELILYSKISTTVDFLRPENKIANVLQFIDSVQGPKRTVVVCRADNEVKAVESSLRYNNRVVFACDNTMNIHDLYNLNVVWGDFEDPTLGPILVCCDSNLVHLNVTDASYLIHYSLPALFSTFCKRFSVLNDNYPSIFKNESRDLKVKVLMDESNVEQLPKILNFLKRCTENVPKILDEVSEKILNEKDLAKVKDLVPLCDNLLSLGICPDTWNCTERHRIFKECDSPADWIPKNGVVTFQILYFHSAVMYSARLLSNTVDGETTKYPQTYSTLSLKMGMYFSKESSRRLHGIPMVGDVCAVSKKQNFFIRCQVVKIISFYKNGNPNYVVIKLIDEEKFEQSRDIYLYHLPDEFKDMKTYVVQVRLANIQPQDKDITFSCLAKNELEKIVEKNEDLFMRGHVAMSVGSCIFVDTLEACLDLSSLSETVVRHNFKQELLNAHAVPNPKHLSILEEMCEKSGLIVKAVTNEQVVPKPIPVLPAAQWAHLEDDLSSVYLASVEDMDKLFVRLVKFESCMKLLNIEINKYVSENTVPLDGSNVGDIVLAKFPDDSMYERARIDHIYSEDKVKCFFVDQGDWRDVSTNDLATITENFITQLPFQAIECRLIGIRPFGEQWTEFSTNWFSDHCFEDAKGNLKHLYVKHFTKEKADCTGGHKYGVALIDTYTNEDIIVNQLLIDLNLAKENVDEIAYLSEIKCNKTVLNNDATVDEEEGSLSGVSEPESNINVPLDKVFLKAPIRSVPLVDSEYETSDSDTWQINRPEDFKALFMRTRPESSKIIPMITANEVQNNADGETSKDTSTILEEKGQLPEKVKDDELKLSKPKICWSQNKNTVKLKILIAGIEDYKLKIEDRAVAFSANHCDVEYGFKLELYGVVDVNKSRHSNKGQYVLVTMTKLMCRNWLALTKEGDSQKWIVYDVDTIEASSDEEVYRDDTLEVIKNIHNTNNGSDSEDDDFLDDVS
The following text describes a protein:
Function:
Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MTVKVHVVYCGGUGYRPKFIKLKTLLEDEFPNELEITGEGTPSTTGWLEVEVNGKLVHSKKNGDGFVDSDSKMQKIMTAIEQAMGK