lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAGSSSRNASSFGAEEDEDGALISTRGLEAFGRKVTTTAGHLIGPIDPTSSTHYQNAMSDLHKQLRRPNLQRSVFSFAKTTPTDLVRSKLSTSEIQYRALTFLPDELLRNIPENENSYSLFQGFQASLPEAGEEKGKKHRRRISRGRKLIDNASEGGSEGDGPPSVAKLKKEKEALNHRLEMMGIRKNMASSEIHGIDNKIANLNSMRRIVLDRLAGLEQEESMLEHENVENRLEEAQEQIEDAEALGKSIVGAEEGDDVENSGMESSFMSESIYEKLPSSASTSSSKGSRRHKTIRRKSMPILHEHFEPGSSIREIQAHDDMVTALDFDVPFGTMVSSALDDTVRVWDMNAGRCMGLLEGHTASVRTLQVEDNIVATGSMDATIRLWDLSKARYDPQDKIKEEQEEGEEDQLAFGEALEREQQTHIPQGTMQDCPLFTLEAHVDEVTALHFRGDTLISGSADKTLRQWDLEKGRCVQTLDVMWAAAQASATMGSTEGTWRQTGRLPDATADFVGAVQVFDAALACGTADGMVRLWDLRSGQVHRSLVGHTGPVTCLQFDDVHLVTGSLDRSIRIWDLRTGAIYDAYAYDAPITSMMFDTRRIVAAAGEDMVKVYDKTDGRHWDCGIGAQREASEEMVERNIIEKCRVKDGYMVEGRRSGMVGIWSC
The following text describes a protein:
Function:
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
Subcellular Localization:
Chromosome. Nucleus. Chromosome, centromere.
Sequence:
MAGREDVVWPGPPGRAAGSLLSPDCDRGAPRTVVLVPQDLSRASSGSRGHGAPAQGAAPTRPRLGFQTQGAASGGLSASGQGNHRRGRPPRKPRKRRVAVTTELTLFEMVALGRSSVQTAVEEWVQSYKEDRELALLDLISFFVQCCGCEGVVTAELYQSNQGKSVVHKMTEKFDQETGLYYKKFLAYPWILTIMWPEKLQNDFYPIVGPGPFWKRFRVNFCEFTELLVHLTHSSVLCDGHLMDTVICMLSGLTNSAVYSLRHTSSLAAMKLLTALASVNQGICTGRRTAQRLYEIESITKLKGRHKYYMELLDQRRHQFQNKPMAIDNIICALFKRTFVPRYRDVSSDIRVICMGELGCWIRLYPDMFLDNNYLKYIGWMLYDKDANVRMKCILALKALYEKRESAMKLGLFFHKFKKRILSMTQDQQPEITSECMQLLRLISEHYVGVFSAMEYVFLFQFVYAAYRPMATAAGELICRRLLAPPPHEGFFGQEPPDEFDRNLQNMKTLIDFYLQGEFHRHVPYLVDGLWEAAPTLVRNWECMTALLLEPRGGRQALTSQQERVLIEILVAAVRQAAEGRPPAGRRLGKKGAREVDGTRRWREHANMSRHFVKVLPQLLSKVPCSPAPQYLDAALLELDCLVQRHSDVAVLEACARAYGTYCDEGGSAHGQAAPACSRLVDMLVDVLTPLLDVFIQHEKQGLFLGHGEMGRICSTLRRLAAFYSTHDLSGWNLYEKMDSLLTFRRHQGSLPTEVVHCALQCTYYALLWQIVAATDRLPSQEALLDLRKRLLKFCLACRVYLSHQSKVLSEKAFILLCDLLLILSHQGPEEDTGLGLLFFVPDHVLQCKLLTFVREHVFLEDAGAAGGRRVYREEDADELHELFHRRNMLAVFCKLIVCNVLEMSAAAAVYQFYLKHYHHFGDIIKETMTRTRQNDRLRNALSLLLCLQQLFQKHVDTYGLGSDPIEFICGPFYSIRLLARRFALTLGFDSARDAAHLIHRRGLAFAFSESPVPEEEARQRFPNLSFLLVLAEFSCKIPPAERAAALAHFQDSIPEGVPVFGEGDMNPMLAYRKSLMRTDYMAQGEEEPAANPFDAICKDSKRPQELPAGTCSTWTPDTLASCAAGDREPRSCSSKERKPKR
The following text describes a protein:
Function:
Acts together with EMP24 and ERV25 in cargo exit from the endoplasmic reticulum.
Miscellaneous:
MISCELLANEOUS: Present with 1070 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLRCAVKKFAYFATFLTIVANIYIYTYPSFHPEQCSWNCSNKNAPLQKDLTFVDKVKNYFSDVREQWHGSHASAGNDEDIHILAFGDPQIKGIWPKTPYVSRLDTYGNDYYLGHIYDMMQQRLKPQVVTVMGDLFSSQWIGDSEFHNRTKRYISRIFKRDPTSIENIKQQNLDEKGQYKANWPEWGDRFNEILDNVKENEADNQELSFGFGYENIHSWNPDLEDFLIINITGNHDVGYSGDATYQHMTRFHDLFGKDNYWIEYETNTTHPWRIVVLNDLLLEGPALQPEFVEATWIFLNQLNERKFNGSTVLLTHVPFYKREGLCVDGPDTRYYPDAHAPESYKSGLLRSQNHLSESVSNQVLNMIFENGKPGIILTGHDHEGCETVYNKKSTSTWEATKNIESDVFVKEITVKSMMGEFNGNTGLVTGHFNTDSMTWEWTFSLCPFAIQHVWWFAKVSLLVTIFTWSSLLFV
The following text describes a protein:
Function:
May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates.
Subcellular Localization:
Lysosome.
Sequence:
MDTWMVLLGLQILLLPLLAHCTAPASTLRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQIMGADFIMSLGDNFYFTGVHDANDKRFQETFEDVFSDRALRNIPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPYYRLRFKVPRSNITVAIFMLDTVMLCGNSDDFVSQQPEMPRDLGVARTQLSWLKKQLAAAKEDYVLVAGHYPIWSIAEHGPTRCLVKNLRPLLAAYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSVRHQRKVPNGYLRFHYGSEDSLGGFTYVEIGSKEMSITYVEASGKSLFKTSLPRRPRP
The following text describes a protein:
Function:
Component of the larval cuticle.
Sequence:
MFKILLVCALVALVAANENPEVKELVNDVQADGFVSKLVLDNGSAASATGDVHGNIDGVFEWVSPEGEHVRVSYKADENGYQPQSDLLPTPPPIPEAILKAIAYIQAHPSKE
The following text describes a protein:
Function:
Involved in the mitochondrial expression of subunits 6 and 8 of the F0-F1 ATP synthase.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MELYQKHLKDVYANFNKLAAVHGETTSNSVTFHVFQQLDSTNLTNYQLENVITQVKELDKGPKDYLYWVILGRCSAHLHVKMLDQLLEEAMIMSDNLHYWESIDKNWYSRVLFLIQSFPTRLYHICRNSIKSILQFQNFSNIFAKKNLFPKVSKSDVLLFPRDAFISQASLLSLIRHEYRGNAKRLRQLRDEHACKIGCLTRAIMSEGVSDAASSSGDKNGISAKADLKQVVSQWIQRLSQLQGQKIDNSESLPDILSITLDNLSHPTDEYFEAKAYFRPSAIERNWPKIFVTLLSAWLSTQIITKNRTSIRLWIDYLYSTAVDFYTNWIQKPILGIFDTIRSNRADSQITLLQTKSLESDMESLQRMVIDFVSDTSPAGINLDLVKQEVQQGDLTYVLQAYEHDLKTPIRTAVSGNLVRTLLIQLQKTKVDVEVALSGIDRLLKSQELVFATVGITPSLIFCYVIIRYVKANIFNNDTLSRAERRQRFRQSLRAAERILVRSQKMNSLDDMSYGLLVFQVNLMAIMSMDMGLSKDVAEDLLQDLEDIQSSSYGVQAQLRAVDRIYRLFKNSI
The following text describes a protein:
Function:
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Sequence:
MNYELVFLAAGQGKRMNAQKNKMWLELVGEPIFIHALRPFLADNRCSKVIVVCQEEERKHVKELMSQLNVAEHRIEIVKGGSERQYSVAAGLERCGTGRVVLVHDGARPFITLDIIDRLLIGVEQSKAAICAVKVKDTVKRVMNGVVQETVDRENLWQVQTPQAFELPILRKAHQLARKEQFLGTDEASLVERIPCPVAIVQGSYYNIKLTTPEDMPLAKAILGELGGIAND
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system.
Sequence:
MNTLSANEAKIHFGDLLLKAQQSPIQINKNGKPVAVVISADEYQSIEALKLHLLQSKAVKAMTDIQTGNLVDGNTFFDELAAGLYD
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MHGRPRKSATPVDENASALKAAEIRSLQSQFLHNHHNNIYTKEALELNAKLIEANPEFMTAWNYRKLAFEHSQSEADSDRIQAIIDEELRVVEIALRKNFKSYGAWHHRKWVISKGNSSTERELKLLNLFQKLDTRNFHAWNYRRFITGLKNISNEKELQFTTDMINDNFSNYSAWHNRSVLLSHLLEKKFEGYFPKEMFLKEEYEFVRNAVFTDPDDQSGWFYHLWLLDQTVKVDTPVLVSSWPPHGSEITKTTFPIILCFNEPVEDVSLHAVSLQIENDLFKNVTWSPLSTNKFNHGQTWLTHLTIPQAELNSSKIFQVKISSESRQGIISLSGVPCRPWSFTFTVSVSASHDLQNVEEHSLRRISVTDESFAKVDVNSNMADFLKSYFEVTGDYEQPAPSKWKSEMIAGEIEQYRELLTWAECKIGKLTLARLLMAYDAMTSSDISIAPMTHVDEVLQLYSELMKLDPTHYRYYKDEYSLVFLKQVTSCKESLMKYCWQYKESNSSDITGSMCLRLNSLSLSQIGSFERLLWVQSLDLSHNQLHSIEGLEALQLLSCLNLSHNNLSSFTALDPLRFLKSLRVLDLSYNEIGAHTVDTRRYLCSSPLSHTLDYDKKFEEVANGDETVVNFWEAYSIFGGLNITQLDIMGNAVAVDERFMSFLVKLLPGLKWVDGEELH
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template. Involved in the regulation of transcription elongation. Involved in DNA repair of damage in the transcribed strand. Mediates a transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER).
Miscellaneous:
MISCELLANEOUS: Present with 2440 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTTFRFCRDCNNMLYPREDKENNRLLFECRTCSYVEEAGSPLVYRHELITNIGETAGVVQDIGSDPTLPRSDRECPKCHSRENVFFQSQQRRKDTSMVLFFVCLSCSHIFTSDQKNKRTQFS
The following text describes a protein:
Function:
Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MLGRRVAILQVNRRVISRKAFIGADIPDSLLNPRANAPLAGSLAASADTSLVIDRETLINGVASPFRNELGETIKGSNAQESRLAEATLAGMAPRGQIQLNPEIAKVIRKNILSLHVPSSIRSTAARHFVEIYERKIHRPAATRMEVDAHVAALFLQNYAAIYQTLSELRKRVGPGFNPERVLDVGYGPATGIVALNDLMGPEYRPSVKEAVILSHPDMQKRAKIILSRQLNEVPDSSAAAVEELLETQQSEGENMDDIPEEDDLVGEVMTKKININTRLRKDVPGSQYYDLIIVTHQLLRQEERFPVQVDENLEHYLNLLAPGGHIVIVERGNPMGFEIIARARQIMLRPENYPEERGKIPRPWIRGSTTKPYNYTVVPEKHTEGSNEIEEGTALLKEITEQHGEVKEADLEFEPELMESLRDRSSTREADYHLKIVAPCPHHGKCPLQTGKPAYYELDEGASLKFCNFQQSVERPKYTIELKKGKVLATPWQTPTDAIGIKGKAKAGSGRENGKNSEVVNYSYLIAERAQNDSATIAAINAQRQRSGAAESGSTVANASETWPRVIRQPTKRKGHVMLDLCAPSGQFEKWVVSKSFDKQAYHDARKAQKGDLWALDAKTKIPGKGALNVAKLEKRHKERIKAAKLESKEKSRIVREEAAELEAVEDSSPAHMEATINALANLHADSFRSASKKRDKNRKLAVDAIRK
The following text describes a protein:
Function:
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Is necessary for responses to strigolactones and may be involved in the ubiquitin-mediated degradation of specific proteins that activate axillary growth (By similarity). Targets probably SMAX1A to degradation upon the formation of an E3 SCF ubiquitin ligase complex (ASK-cullin-F-box) containing MAX2B and KAI2IA in response to (-)-germacrene D in the stigma (Probable).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MAKTPIPFTTLNDLPDVILSNIIAAVSDTRSRNATALVCHKWLVLERSTRTSLTLRGNIRDLFMLPTCFRSITYLDLSLISPWGHPLLASRATDAPDNDSALIAHLLRHTFPSVTSLTLYARDPNTIQFLPAQWAHTLKHIKLVRWHQRAQLASGDELNLLFIGTPQITSLDLSNFYCWTDDVPPALQSNPNVACNLTRFNLLNASFPEGFKTDEIKVITKCCPNLKEFKVACMFDPRYIGFIGDEALVCLATNCPKLSVLHLADTSVLSNCRGDPNDEGFTVEDAQFSVSTLIEVFSGLSLLEELVFDVCNNVRDSGPALEILKTKCPKLRSLKLGQFHGISMPIESKLDGVALCQGLLSLSIRSVGDLDDMGLIGIGRGCSRLTKFEIECCKKITMRGMRTLASLLRKSLVDVTISCCKNLGASSSLKALEPIQDRIQRLHIDCVWDTVEEFENLDGVEYGFDLNEASGGEASSNPAGFGDTFGSMDDDLMNNRNKRCKYSYDLNSVYVENNGHGNGFCGRTWDRLQYLSLWIGVGELLTPLAAAGLQDCPKLEEIKIKVEGDCRLWSKPSERAFGLSTLIQYPKLVKMHLDCGDIIGYAHTAPSGQMDLSLWERFYLMGIRHLNLRELDYWPPQDRDVNQRSLSLPAAGLLQECVTLRKLFIHGTAHEHFMMFLLRIPNLRDVQLREDYYPAPENDMSTEMRADSLSRFEVALNRRQICD
The following text describes a protein:
Function:
Has aromatic amino acid transaminase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MVAYQPKDLSHHLSLESSARRPSPLKAAALSKSKTGINIVSLAGGLPHSDYFPIRTLSTAVYRPDGKPENNNVSKIPLQELSLGMEPTEDNDFGLSQGLQYGQGFGALQLAAFVKEHTRIVHQPKYEGWDVMLTAGNTNALDTCLRMLLNRGESLLVEEYTFPSALQTIEPMGINCIPMPMDLNGILPEKLEELLSSWNTKARGCPKPHVMYVIPSGQNPTGSTLSNERRARIYEICQAHDIIILEDEPYYFLQMDNFDGKIPEEQPTVSNETFLSQLITSFLSIDTEGRVIRLDSMSKVVAPGTRLGWLTGHPLFMERALRQNEVNIQSASGLSQVLLHGILHTWGQEGYLEWLKQIRFQYTRRRNALLLAMNKYLPEGLCSYIAPEAGMFIWFEVDRSRYLHSDKFKTVPEIETDIHEQAVDAGVNLACGHWFIVDSSKNDRVFFRVTFAAANFEDFNVAIERFAAVLNKNFK
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSYSGNRVFRGKKEQEAYDKTLAGRYVKLVKKNHFLFFGLPFLVSIVAGSIYLQKFTSVKWEKYDEKYQQLGEEEMLNLIENKRTVDKKNDYYRLQGLLNDHTNQVADDYEIVRVQRRKEDEPVWDRQ
The following text describes a protein:
Function:
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MVSSQINKIQPVPYLDEIYHVPQAQEYCRGNFSYWDNRITTLPGLYLISVGVITPLSSWLSKNLCETHHLRLTNVVLSLSNFVLYVWLIKKIHQDSGKHGTWKGIASALNVALFPPLFFFSFLYYTDVAASFLVFLMYGLHMYGKNALAAVAGIAAVVVRQTSIVWVILVAVGCFDLSLQKLLLTAKDRKFHILSSWHQVQVVLKKFFNLAPAPQKIQLVGKLILELFPYILVGLIFAAFVVINNGLVVGDRDAHQATIHVPQLFYLFALVTLFAAPHWISLVLPFSKACLKNWYVILVAVGLVGLIVRYNTLVHPYLLADNRHYTFYIWKRVFEYQPWGRYVIIPLYLFGSFATYRTMSTSKSFIFALAFIVCCFVALVPQRLLEIRYFFIPFLFVRLHIRPRSWMALFFEFSMYIAINAATIYLFITRPFYWADSPLTQRFMW
The following text describes a protein:
Function:
Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions probably by signaling through the G protein-coupled receptor NPY4R2.
Subcellular Localization:
Secreted.
Sequence:
MAAARLCLSLLLLSTCVALLLQPLLGAQGAPLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRYGKRHKEDTLAFSEWGSPHAAVPRELSPLDL
The following text describes a protein:
Function:
Essential for the homeostatic regulation of sleep and motor activity, by depressing hyperactivity and wakefulness. May function, at least in part, by ensuring dopamine biosynthesis.
Subcellular Localization:
Cytoplasm. Note=Localized to distinct puncta in neuronal cytoplasm.
Sequence:
MSSQGHHKMSGGGKKGAMEQDYTDVVDLGDRFSADMARLCMNEQYADVEFIVEEERIPAHRVILAARSEYFRALLYGGMAETTQRQIPLEVPLEAFKVLLRYIYSGTLLLSTLDEDSTIDVLGMANQYGFQDLEMAISNYLRQYLALDNVCMILDAARLYNLEELTEVCLMFMDRNAGDLLLHNSFNTLSKESLEEVLRRDCFFAPEVQIFLAVWKWSRFNSNVDFKSVVSYVRLPLMNLEHLLQVVRPSGILDPDKILDAIDERSTSKALPYRAALWPEENVAAETFLSRCIQGECRDALLDGDVTTYDMENGYTRHCITDSKDAGIVVELGTFCMINHIRMLLWDRDSRAYSYYVEVSGDQQHWDRVVDYSDYHCRSWQYLYFEARPVRFIRLVGTQNTVNRVFHVVGLEAMHTAKVPRLVNHFVAPKTNVATVEMSAIVTDGVSRTRNALINGDYVRYDWDSGYTCHQLGSGEIVVRLGQPYYLGSMRLLLWDCDDRTYSFYIEISTNRKEWQMVVDRRNDRTRSWQNFHFTPRPVVYIRIVGTRNTANEIFHCVHLECPTQDKNYLKKIADMEKEREKREKEKKTAKTDDDNIASTSGSSLASGHAESPSTSSSSSQSVLRSIHWPPQTREVAVAPLTPPALSPPGTPALPAPLTPATSSPHNNHEQNQPSNISADASHHTSPSSRSNPSPSLSRSRSQSAELEPVPPLVELDTRETL
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MEESEVFIRRKHSGGPLLPPKFGSHIPRHASFLEQKLLPGIRSHPMQSQSNGKSSSTAQLTIFYAGEVNVYDNIPADKAQAIMLLAGESCVSKPMATEKPKAEVKKPTDSTSACKLQTDLPIARKLSLQHFLEKRRRRRTGKSPYSTQHQESEPREDNKDSNDQPISLSPFASRLG
The following text describes a protein:
Function:
Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle (By similarity).
Miscellaneous:
MISCELLANEOUS: No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.
Subcellular Localization:
Nucleus.
Sequence:
MSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFSEMLEAKV
The following text describes a protein:
Function:
DNA-binding protein involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA by preventing activation of the AIM2 inflammasome, probably by sequestering cytoplasmic DNA and preventing its being bound by AIM2. Also inhibits activation of the AIM2 inflammasome via a direct interaction with AIM2, which prevents the interaction between AIM2 and PYCARD and formation of the AIM2 inflammasome. Binds double-stranded DNA (dsDNA) in the cytosol. Has anti-apoptotic effects due to inhibition of the transcriptional activity of TP53/p53. Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Accumulates first in the cytoplasm, and is translocated to the nucleus after a delay, where it is primarily chromatin-associated.
Domain:
The HIN-200 domain 1 mediates non-specific double-stranded DNA (dsDNA)-binding via electrostatic interactions: it recognizes both strands of DNA. The HIN-200 domain 2 mediates homotetramerization and interaction with AIM2.
Sequence:
MSNRNLRSSTNSEFSEGQHQTPSSDSSGHGEDQPQASPGPNKKSHTPKKNISKGAVLHEKPMTVMVLTATEPFNYKEGKENMFHATVATESQYYRVKVFNMDLKEKFTENKFITISKYFNSSGILEINETATVSEAAPNQIIEVPKNIIRSAKETLKISKIKELDSGTLIYGVFAVEKKKVNDKSITFKIKDNEDNIKVVWDKKQHNINYEKGDKLQLFSFHLRKGNGKPILHSGNHSFIKGEKLLKESFEGDGYHKGPKQVVALKATKLFTYDSIKSKKMFHATVATDTEFFRVMVFEENLEKKFIPGNTIALSDYFGMYGSLAIHEYSSVSEVKSQNKEDSSSSDERLIEHLKICDLHLQTKERLVDGEFKVYRKSTGNNCICYGIWDDTGAMKVVVSGQLTSVNCEIGNTIRLVCFELTSNADEWFLRSTRYSYMEVIMPEK
The following text describes a protein:
Function:
A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular Localization:
Cell junction, desmosome. Cell membrane; Single-pass type I membrane protein.
Sequence:
MTWFPFRTTGALTILMAVLLVHGELRIETKRQHGEDETAVQQAKRRYKREWVKFARPCREGEDNSKRNPIATITSDFQATQKITYQISGMGIDQPPFGIFVVDRNTGEINITAIVDREETPSFQITCHALNVLGQDVEKPLILTVKILDINDNAPVFSQSVFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGIPMFLLSRHTGEVRTLTSSLDREQVSTYRLVVSGADKDGEGLSTQCECSIKVKDVNDNFPIFRESQYSARIEENTLSSELIRFQVVDRDEEFTDNWLAVYFFTSGNEGQWFEIQTDPRTNEGILKVVKPLDYEQLQNVQFSIAVKNKAEFHQSIISQYRVQSTPVIIQVVNVKEGISFRPPSKTFTVQKGISSKTLVNYILGTYQAIDEDTNKAASNVRYVMGRNDGGLLIVDSTTAQIKFVRNIDRDSTFIVNKTITAEVLAIDGDTGKTSTGTIYVKVPDFNENCPTIVLEKKTICSSSPSVIVSARALDNDKYTGPYTFSLEEQPVKLPVVWSITTLNATSAVLRAHQQLSLGTHRVSLIVTGQDRLCETPESLTLEVCQCTNRGICGTDGTTDPGNVRDTKSSMRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGTGPIGGMTGGFIPVPDGSEGTIHQWGIEGAQPEDKEITNICVPLITANGADFMENSEVCTNTYAGGTVVEGASGMELTTKLGAATGSGAAAGFGLGVCSTGQSGMMRTRHSTGGTNKDYSEGAINMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGVGAPGSPVGSLSCCSFIADELDDSFLDSLGPKFKKLAEISLGVDDEAKQSYTPTKDGGSGIESSGYSVEVQQSESARYQTLSGSQGASALSASGSVLQPAISIPEPLQHSSFVVTETYSASGSLAQPSTAVFDPLLTQNVTVTERVICPVSNVPGNLHGPMEIRGSRTMICTEDPCSRLI
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MTATEFGIVYAVHIITSHFGSVASKVCECLLRRGPLSSREISRLAESDINHTKVKDILYLLIHHNCVQAFSIDPPDGSESKATVQYIALFRNIIHGARYNKFSKVVNEELGSQCSGLLDGLLSNGRLTLEQLIDRDRDSKKPMGSEAIRDSLQKLVAARFIERVPSPEPVLGNKDEGPAQKKRGAKASKIFKEPESLEERILEAATPVDAIRFPFIFEQGSSSTVADDDSNIPEGKRKQPEVDYSSGPSNEVIWRPNFEELIRRLRHKACVEIVKERRDEGCANVMKAMLEVGRSQEKKAKTDKSVPMSMGSIYEELIKTDAGREMTQARVEACLEQLSATSSYLPAFVIESDDSYIVVVMRRYGKEAFRMFRYLSQEDRFVETDKIADAALTEKKDTPQIVLKMWKDGYLHMQKLAVTGVYMPFLLWKVNKLIVSRRMLDEMYHASLNLSLRLTHEKDSEKELLLLPMEKLEGALKERRNKYRAKSVLLTSASFKLDDAILLFHDF
The following text describes a protein:
Function:
Phosphoinositide-binding protein that plays a role in regulation of ergosterol distribution in the cell. Facilitates ergosterol transport between plasma membrane and lipid droplets.
Miscellaneous:
MISCELLANEOUS: Present with 3080 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Lipid droplet. Note=Associated with endoplasmic reticulum-lipid droplet contact sites.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.
Sequence:
MITQDTPALNPTEEHYLKRELLRCQLDYEIGKLNDQFALRKFGYPFSPNDPTAPQPISNNDSSPVLGGKGHFSVNYPMLSYVLQEFISTFPLLSTNLLVDEKFWQSKVQVFFEHFMSLGFSESYDREEASKRKKVSKKLSKVILLLFNSGVGSFQEQAYYNEDKFVLQSGQARKRSNIEKFAMPTRENLENLLTNESVFINGWDVNIISVFNKNSRKCTESVDNDKSSKSTPTSSPKSHAIKSFASTSKWMKNAFNNTINSTINSMPESSASLFSKLSLGVPSTKSKQSRKHHYFLIKIKKQDDDDQDNSNEENSNLDHHAGYFYVTRTYSDFKKLSHDLKSEFPGKKCPRLPHRNKKVTSMITKTEVLHNGQTKSAAREKIVNTFDTDLQSASESDNSSFLQTTNELSATETVLTEKETETLRKNILNEIKEEDNIDEDEYEEEGEGEESDFDEYKDASDSKINTLVGEKMRTSLRQYLRTLCKDAEVSQSSSIRRFFLSGPNLDIKDINPKIADDIRNRALIDVSNLENQIRFQQMALEKSLKLQDSMKDFKTSLLKDEKYLMSLLVEIKDNTKVEDLSPLLQDFVEWCKIYISSMIYQMFLGNDNSYELYTQIRRLHKLMPYTVMGQIMKFTNPIAIMRGMIELFMAQPFGGHSLLQTMFSTILTDDLKTQKVAIKELERKIAEMDPGASVVTKCLKDFVFNNDTKDEHDTKLFTMDAVNAESESMNMPVPLIVLMKSAAANLIPDEVVAGLIESYSSWKLQKEDTDALNVTSEDQSGIYFTHVKDLWQLYIKEHDKQLMRQLWQDPELTQMLKAIVTMIYEPMVKIFKVARMDVALKNFEKFMSDLIRLVDDVINGQLGVSTQFDVVEEIHNLVTKHQDAFFEFIHDVYLNDSEGIFEGFITWITTIVKFLQKSKFGGPSERIDFNKLICRDDIDIDVKLLKVQVNNVLNKKIGARKIYKKLLDLKVKQGTKQNNKHAAGILQKNWSDINSLVMPSSSGSFGLGDGDLVDLDLDTGDYDFLHKENEVELEKQYKDLLNLVVDESEIDKLRSQVFAQELKNYLEAQIAKK
The following text describes a protein:
Function:
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze TTP and the modified nucleotides 5-methyl-UTP (m(5)UTP), pseudo-UTP and 5-methyl-CTP (m(5)CTP). Has weak activity with CTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. Important in maintenance of cell shape.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSLYLASGSPRRQELLAQLGVTFERIVTGIEEQRQPQESAQQYVVRLAREKARAGVAQTAKDLPVLGADTIVILNGEVLEKPRDAEHAAQMLRKLSGQTHQVMTAVALADSQHILDCLVVTDVTFRTLTDEDIAGYVASDEPLDKAGAYGIQGLGGCFVRKINGSYHAVVGLPLVETYELLSNFNALREKRDKHDG
The following text describes a protein:
Function:
Acts as a negative regulator of the Wnt signaling pathway required for anterior neural structure formation (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The CXXC zinc finger mediates binding to CpG-DNA.
Sequence:
MHRNDSQRLGKPGGAPESLQMANNNFLSTLSPEHCRPLAGECMNKLKCGAAEAEIMNLPERVGTFSAIPALGGISLPPGVIVMTALHSPAAASAAVTDSAFQIANLADCPQNNSSGAGGNPAKKKRKRCGVCVPCKRLINCGVCSSCRNRKTGHQICKFRKCEELKKKPGTSLERTPVPSAEAFRWFF
The following text describes a protein:
Function:
Transcription factor required for the asymmetric cell division involved in radial pattern formation in roots. Essential for both cell division and cell specification.
Subcellular Localization:
Nucleus.
Sequence:
MDTLFRLVSLQAASEQQQQQQQSASYNSRSTTSSGSRSSSHQTNASYSYYHHSSNSGGGGGGGGGYYYGGQQPPPSQYYYLEPYQEECGNAPHHQLYMDEDFSSSSSSRHFHHGARVQQQQPPASSTPTGTAPTPPLSTSSTAAGAGHGLFEAADLSFPPDLNLDFSSPASSSGGGTASSGAVGGGGGGRWASQLLLECARSVAARDSQRVQQLMWMLNELASPYGDVEQKLASYFLQGLFARLTASGPRTLRTLAAASDRNTSFDSTRRTALRFQELSPWSSFGHVAANGAILESFLEVAAAASSETQRFHILDLSNTFCTQWPTLLEALATRSADETPHLSITTVVSAAPSAPTAAVQRVMREIGQRMEKFARLMGVPFRFRAVHHSGDLAELDLDALDLREGGATTALAVNCVNSLRGVVPGRARRRDAFAASLRRLDPRVVTVVEEEADLVASDPDASSATEEGGDTEAAFLKVFGEGLRFFSAYMDSLEESFPKTSNERLALERGAGRAIVDLVSCPASESMERRETAASWARRMRSAGFSPVAFSEDVADDVRSLLRRYREGWSMREAGTDDSAAGAGVFLAWKEQPLVWASAWRP