lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells.
Subcellular Localization:
Nucleus.
Sequence:
MEPITFTAKKHAFPSEISVDFSLQLVGSLPVHYLTTMPMLPWVVAEVRRLSTQSSKKEHVVNQIRLCVSPACLKCEPDPGKSHQWDPLICSSIFEYKPQQVHKLIHNSHDPSYFACLIKEDTASQQSICYVFKADDQTKVPEIISSIRQAGKIARQEEFHSQSEFDDTFAKKFEVLFCGRVTVAHKKAPPALIDECIEKFNHVSCSRKAELDMLAQNSEAISTVGGFSLTDKFRSVFQPGGSAEQDRKPMRKSFSQPGLRSLAFKKEFQDAGYRSSSFFGGSFEENDIQSHLISGHNIVQPTDIEENRTMLFTIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSENGGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQQTSRVPVQQCEGCPMHYLHKLCERIEGMSSSKTKLELQKHLTTLNNQEQATIFEEVQKIRPRNEQKENELIISFLRCLYEEKQKDHVHIGESKQTSQISAETIRNELPTNAPRFRLDMLKSKAKRSLTESLESILSRGSKGKGLPEQSGSVDLDSSVSSTFSNTSKELSMGEKELPALPEGSCPPPGSLDDLSSTSGSPLPEEAAPPSPRQEFRRRANTLSHYPVEGQKPPEPPEASPGLPQRKLMSLNPPVDESKSRSGQSSTPALPPHRLNPSASSPNFFKYLKHNSSGEQGGNAVSKSISYRSALRKKLHSSSSVPNFLKFLAPVDENNTSDFRSTKRDFESKTHHHDSNNESPLKTRRHSWRQQIFLRVATPQKGCDSPSRFEDYSDLGDLPPRSPLEPVCEDGPFGPVIEEKKRTSRELRELWKKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKDVTSVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQYHLKHPFPNKQQPKDTPYKELLKQLTSHQHAILIDLVQNVPFWRSWSPCALGRASMPVRRSSETSKRDTWSGCLRVLKGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDPEVGYCQGLSFVAGVLLLHMSEEDAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYSHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGSEVIFKVALSLLGSHKPLILQHENLETIVDFIKNTLPNLGLVQMEKTINQVFEMDISKQLQAYEVEYHVLQDELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEELQVANGKIQSLEGTIEMLLANENRLKQTALALELERSALLRTVEELRKKAAQLGNGDLGAAQPELTEDGH
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MERDFMGLAVKQETSDETIDAVPVKSLAMQWSFSNKGSSAVPQLLSFQGGQEDNSNKLKTGFDSLTSTGLVTVTTRESFESEHKSYTTTQKNVVHQKQGGIGYTMTTNQKSPTHSYVSTSGHNNLIGSVRAPMKNPVAAIPSTSPVVGTTDLRNSSKISGAPTQLTIFFNGSVCVFDNISPEKAQAIMLLAGNGTPTTPTAIPSPTPLQTKVTRSSILDGHVLNQTYGKTPQHCSPVPLTSITVSHSAAAKPLPAGVPVFSSNIVGPSKAANSLGPVSGTFLSQDTVPQFRRKSLARFLEKRKERVISASSPYGDKKSLDNEGGAGGAAGRRNLSANSSGSCPVTAIN
The following text describes a protein:
Function:
A putative lipoprotein that seems to be specialized for the initial steps of macrophage infection. A non-acylated fragment (residues 26-185) binds phosphatidyl-myo-inositol mannosides (PIMs). Limits, in a TLR2-dependent fashion, bacterial uptake by host (mouse); this effect may be mediated by nonacylated fragment 26-185. Plays a TLR2-dependent role in host phagosome maturation arrest. Plays a TLR2-independent role in chemokine production during the first 24 hours of mouse infection.
Subcellular Localization:
Membrane; Lipid-anchor. Membrane; Single-pass membrane protein. Secreted, cell wall. Secreted. Note=Mature form (about 28 kDa) is associated with the cell wall and membrane fraction, secreted form is seen after 1 week axenic culture in Sauton's medium without detergent, this form is about 20 kDa. May not be acylated, cell wall association is unchanged by mutation of the putatively acylated residue, and the mutant's migration does not change.
Domain:
An extracytoplasmic domain (residues 26-185, without the lipid-anchor, either periplasmic or extracellular) decreases phagocystosis by macrophages; when added exogenously to the deletion mutant initial bacteria uptake by host (mouse) decreases to wild-type levels. When added exogenously however this region is not sufficient to restore phagosome maturation arrest.
Sequence:
MARTRRRGMLAIAMLLMLVPLATGCLRVRASITISPDDLVSGEIIAAAKPKNSKDTGPALDGDVPFSQKVAVSNYDSDGYVGSQAVFSDLTFAELPQLANMNSDAAGVNLSLRRNGNIVILEGRADLTSVSDPDADVELTVAFPAAVTSTNGDRIEPEVVQWKLKPGVVSTMSAQARYTDPNTRSFTGAGIWLGIAAFAAAGVVAVLAWIDRDRSPRLTASGDPPTS
The following text describes a protein:
Function:
May be catalytically inactive.
Miscellaneous:
MISCELLANEOUS: The gene maps to 3q26.31, a region associated with Cornelia de Lange syndrome. However, PubMed:15168106 failed to identify specific mutations in a panel of DNA samples from patients with Cornelia de Lange syndrome.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESGFDQFQLDGAENQNLGHSETIDLNLDSIQPATSPKGRFQRLQEESDYITHYTRSAPKSNRCNFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKSFRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKGTLKAEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGYPSVDESFRQSRSNLTSLLVQPISAPLVAKLISSPKARTKNEACSSLELPNNEIRVVSMQVQTVTKLKTVTNVVGFVMGLTSPDRYIIVGSHHHTAHSYNGQEWASSTAIITAFIRALMSKVKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPVASPSLQQLVVEKNNFNCTRRAQCPETNISSIQIQGDADYFINHLGVPIVQFAYEDIKTLEGPSFLSEARFSTRATKIEEMDPSFNLHETITKLSGEVILQIANEPVLPFNALDIALEVQNNLKGDQPNTHQLLAMALRLRESAELFQSDEMRPANDPKERAPIRIRMLNDILQDMEKSFLVKQAPPGFYRNILYHLDEKTSRFSILIEAWEHCKPLASNETLQEALSEVLNSINSAQVYFKAGLDVFKSVLDGKN
The following text describes a protein:
Function:
Involved in embryonic and larval development. Plays a role in oogenesis by regulating mpk-1 phosphorylation and oocyte maturation in response to major sperm protein (MSP). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of receptor egl-15. Plays a role in fluid homeostasis probably downstream of receptor egl-15 and adapter soc-1. Promotes vulva induction and negatively regulates fertility probably downstream of receptor let-23. Negatively regulates daf-2-mediated repression of dauer formation.
Subcellular Localization:
Cytoplasm. Note=Localizes to vesicle-like structures.
Sequence:
MPRLALRQYNFYYRVNGEKAEELLKEYGEDGDFLLRYSESNPQNFSISVRVAEDKILHIKVTKYESDMLSIFEDERTTPNQFGSITELAEFYMEFPEKLREKNGLFLELKKPVYVPYHLEACAEEQRRTQLYRWWHGNLPASSANKLLQTEKNGTYLLRASQHIPGALVISAKTEGQVVHLTIYQDPSTGRFNIDGDRTKFQSAWLLIDSYSKNPIVEKGEASRVLYLEEPLFNTFIEADLFVDRFEIIRRPINPRESMEKTGISEEFDRLSQEALPAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRFENSQRTKNVTFACEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENERKEKCARYWPAEVNKPEVHGDISLTCTIERKVQRAVSDEVKAELEQEKTNRIAKGLVPEAELNGDGISYILRTLVMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFNAQPIAASLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLCPMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKNNNPYPVKSFIDGDTDAFDFPRRLRPTPNASRPSSARQVTSSRPSSSASSRTSHSRPRTGPQAEPIFERSTSSTSSSSTLLKSTKK
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MQIIGKTNFDFMGKKKITFVISSIIALLGLIGVGQIALGTANMGIDFSGGTAVQLNFSQPVAIDQARHALAKHGFKDANLQEVSGGNKLLVKVGKATHVQGPAADAIEDAFRKEFTDNRFVIESSTEIGPAIGDKLRKDTLVAVVISLVGIVIYIAWRFDFAFGVGALAATLHDVLAMFAVFFVMQKEINLLFITAVLTIAGYSLTDTVVVFDRIRENLHKNVKDSLTAICNFSINEVLSRTIITALTTFLATASLFFFGGEVIHDFAFALLVGIIVGVYSSVFVASPIVVIWGSRNKETKA
The following text describes a protein:
Function:
Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAQQQQQQQHHHHLQHQQQQQQQQQLQHHSNLLLLQQQQQQQQQQQQQQQQLLQQEQQLQQYDNNLYSQNYNMEEYERRRRREREKYERQQGIQSDDRETSLFSEPRRLTEGDAEITAALGEFGDARNYINQYTVGISRHAPGGGSGNGSIGNNPRLQAPMIQQQVSSSISSSASVASSLLPPGLGQTQQQQQQQQQQQQPRPPTYLKQADNKPPYNGRGGYPGQPMKNDIPSSSGMAPPRGPPKLNSNSSSITNNAAASSSSSLLGPPISTQVPNGREKSFLGPPTTGTALHNGGGRFAQPVSNKRPGVGIQPPPPQEKDVRSMLSEMKNHFQVTPLNPIAATPQAPTRENYNLNAPNKFKYAFDIVDPIMPLLNSPPSVTPSSLITPIAPMTSPIAPLLTTPPQASQLPLGSGSGNGAAISATSLSTTTAAAAAAAAVAGVAATVAATVAPIQQLPPTPPKAMSVTPPTAKPLKIEKNPILEKQDSCLENDLELSESEDERKKDGRSPGSSSNGSESDSTESGSESSSKGEHNHHHHHQQQQQQTQQQQLHGHHPQSHHHQQFLQQQLQRQQQQQQQQQQLTANGGKKKYSQTIIASGANTITGLLTSSGGLGSSSGNNSSGGGGGSGNGGTTSSSSGGSMGGSGGSSSSGGASGGGGGGGGSGSSSGIGSGSSSNKTPSPTDSNKWNLSRFFHKPTSQTSSESVSPGNVSMKVPGILPGGAQIIPESIDVTTAIVKNEKIHHDDHLMDIDECDEDDDDVDEQHQQLRYGAGLSVTPVAVKKEEDLGLLTAAAIPKSQIKRESETQISHQRLSESATSGSSSSSCSSSDSAASASEVVPMPGPGETLQIPGVPAAITSVMRVPPINNMQKSQSMSVTVTPIAPLPASPKPRQKKPRKKKMMSVLTPPLLDSSDEDEPSTKHSSLVVAQAQAAVVPPPSTNSTTTSATTTKKGRGRPRKQQQQQSAGSGNLSSASAGSSSQAKGPTLTAAKKTLVKASASSSTSNTNSSSVLPRKREHSSQSSSNGNTPTKKMSSIPMMPAAAASAAATLLQPPAVAAANAVAASSSSSDEESSSSSCSTSKSSSSSSSSDDTETQKTNCRIVKLNKTVPVTAAMAPLAKRSSYHRRSGSSSPTSSSSETDKPNSNSHNNLGIAAISNSNSNSNNNVIVNNNLQQQAMPQQSPYKVPLSGGSQQLSSSDSSSSSSGSSSSSGDEDDAKREKNRERKPKSDKNKISTLTRIFNNKEGGAKKQGQVVIIDQSEEQLQQQQQQQQQVQIRDPLPPPSLLSQSGGVKQRMTPTQQQQLGAGLASPARTTTPLLTSLICKIDLSKLSRERILRLKKLAPSSSNQQNGHLTPNGHVVQGGSSPAGLSKVKHEHHQLHHHSQQAHSHPVKPEPELDSLYETKFRPTNVKQEFQLKQERDRDRNRERDQQQQPPPRRRKRSSSSSSSPYKEKKRKKEKTDPMLTNAKDQMLQINPMLLPSNNHERLSYDKYQLLQEDAAAAAAAAAAVAVVNSSNGQKLFQSSIGGGTGATAVGPLSIMAPSTCSEAVQTTPPTSVTGAGAPASLVSQPPPPPRLIYRSYFDREEEHPSDDLRKSKQFLQEAVQRKHAADSERDSFNQVTLYLEAVAYFLLTADAMERCSSETATWTMYKDTLSLIKFISSKFRPYQQSANCQQETHNKVAILSLRCQSLISLKLFKLRRVNCRAIINSLTDFFRNGRGDIVNGNTPSSISPSNSVGSQGSGSNTPPGKIVPQDIHNQLCKQNEYLTYVNSAHELWDQADRLVRTGNHLDFFRELDHENGPLTLHSTMHEVFRYVQAGLKTLRDAVSHPTHQSQ
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MSTQSLSSLLSRASIDDHEEVLRSCDAALAKSRSDIQAQHVKVVALLKLDRYEDCLRVFEEGGDILKKKAALEYGYTLYKTGHPETAIDVVSSLAGDRGARHLEAQATYRAEKFRRTAEIYQGLSRESAPTVNEENDLRINSWATDAQLQWKGHPESVRHTRPTRDDLEAFETVYNAACLSIAKGEFDQAGLLLKRAKELCRTSEDLTPEDRDAELLPIAVQQLYVLICQGKSAEAESILEEISIKDISELSTKRIGQNNAAIARGTTANPYALYEALHEVPDSTDNDKLFDYQYNVMTGNLHAVDLLVHKYDGIIRSTSKALSQAPFPSTEASTNLLSVYNVAARAKGETGTPALKAILSAVERRPKDIGLVLTAVQLYVNQGNTTSAIVILERTLQLLDESISEQDKEIRFNPGLLSVLIALYKREGRKTQIKAELAKAATFWSGQAAQPTSLLRAAGASLLHSSLASDTSQAAELFKSLYEKTPDDLFAVAGYVASHAAIDYSQVEAQAKYLPSVDDLISDIDVAALETAGVAPSSSTTAAAAAAIAGARKRPAPTKDRVAKRVRKSRLPKDYDPSKTADPERWLPLRDRSTYRPRGRKGKQRAAERTQGGVVSEKSEETTLSGQQQQQKPQTGGSSQKKKKKGKR
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized (By similarity).
Subcellular Localization:
Mitochondrion inner membrane. Note=Matrix and cytoplasmic side of the mitochondrial inner membrane.
Sequence:
MIIRFKINEIECEVNEEKEDITILQACTANGIEIPRFCYHEKLTIAGNCRMCLVYVTNEEKLLAACGIPLDENFDDESIETEIDEILKAREGVMEFLLINHPLDCPICDQGGECDLQEQTLAYGLDTGRFYIKKRAVEIKTFGRLIKGIMTRCIHCTRCVRFLTEIAGVNELGVLGRGYNMEIGTYKKNVMIESELSGNIIDLCPVGALTSAVYAYKGRPWELKNIKGIDIFDTLLTPINYQVKGGEIFRILPRINDRINEEWITDKVRFHYESYKIIEKIRKETPSYKIQANKFIELTWKTALKMVFKVLLNKKNKVDLIIGSKINSTNLRIYKELMNRLGSKNYITENGLMFKKFNYDLRENYINSNDLYNVDKNDLVLLCGINLRVESPLLNIKLRNVNFGDDEIESVKKIGIIGNKFDWKHESEYIGATLNSMLKLFEGRLPYCQQIKKSKAPLIIVGPSLLTRISLTLQEMRAIFMKACNLKPENILIITQGANFGMALEEGLFKEKFSIGGNVLYSIDSNEVQVTNKINYVIYQGIINDKFENKIDLYLPSKHYFEDFEGDREVYMNTFGQRSEIEKLSISKGNKIKENSMIGYIQLMYLNNKEMTRKEKEQKDIKLSYREMKKEEKRKIKVNKYLTINNIIENYYMTDINIRLSKNLMITGQLRKEKKIMEAGIWKNRKCI
The following text describes a protein:
Function:
Involved in the activation cascade of caspases responsible for apoptosis execution (By similarity). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Loss of zygotic DCP-1 function causes larval lethality and melanotic tumors.
Sequence:
MTDECVTRNYGVGIRSPNGSENRGSFIMADNTDAKGCTPESLVVGGATAASPLPANKFVARMPVERYASEYNMSHKHRGVALIFNHEFFDIPSLKSRTGTNVDAQELKKAFENLGFAVSVHKDCKLRDILKHVGKAAELDHTDNDCLAVAILSHGEHGYLYAKDTQYKLDNIWHYFTATFCPSLAGKPKLFFIQACQGDRLDGGITLEKGVTETDGESSTSYKIPIHADFLFSYSTIPGYFSWRNINNGSWYMQSLIRELNANGKKYDLLTLLTFVNQRVALDFESNVPATPMMDRQKQIPCLTSMLTRILRFGDKPNGNKAG
The following text describes a protein:
Function:
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Sequence:
MPRALNDRSSALTAQNLIALPERFGCPVWAYDGDIIAERINQLRHFDVIRFAQKACSNIHILRLMREQGVKVDSVSLGEIERALHAGYQPGQEPAEIVFTADLLDQATLLRVTELNIPVNAGSIDMLDQLGQQAPGHPVWLRVNPGFGHGHSQKTNTGGENSKHGIWHEELPRALKKIEHYGLTLVGIHMHIGSGVDYQHLEQVCDAMVQQVITLGHDISAISAGGGLSIPYQFGDDVIDTEHYYGLWNSARERIAAHLGHPVSLEIEPGRFLVAESGVLIAQVRAVKDMGRRHYVLVDAGFNDLMRPAMYGSYHHISLLPADGRDLTSAPLIDTVVAGPLCESGDVFTQQEGGGVETLALPAAVIGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFEKGQPRLIRRRQTIEELIDLERV
The following text describes a protein:
Function:
Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MMETERLVLPPPDPLDLPLRAVELGCTGRWELLNAPGAPESTLPHGLPPCAPDLQQEAEQLFLSSPAWLPLHGVEHSARKWQRKMDPWSLLSALGAPVPSDLQAQRHPTTGQILGYKEVLLENTNLSATTSLSLRRPPGPISQSLWGNPTQYPFWPGGMDEPTITDLSTREEAEEEIDFEKDLLTVPPGFKKGVDFAPKDHRAPASGLLSLSRLLEPLDLGGGDEDETDAVGQPGSPRGDTVSAPPCSAPLARASSLEDLVLKEASTAVSPPEPPKPPPQEQWAIPVDVTSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLERHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFRNTFADVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPDHVSIILLSATVPNALEFADWIGRLKRRQIYVISTVARPVPLEHYLFTGNSPKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALAELTKRLGALEEPDTTGQLVDLPEYYNWGEELTETQGLIQRRIIDSVNGLKSLSVGRVVVVKNQEHHNALGVILQVSSNSTSRVFTTLVLCDKPMSEDPQQKGPASPDVPYPDDLVGFKLFLPEGPCDHTVAKLQPGDVAAITTKVLRVNGEKILEDFSKRQQPKFKKEPPLAAVTTAVQELLRLAQAYPAGPPTLDPVNDLQLKDVSVVEGGLRARKLEELIRGAQCVHSPRFPAQYLKLRERMQIQKEMERLSFLLSDQSLLLLPEYHQRVEVLRTLGYVDDAGTVKLAGRVACAMSSHELLLTELMFDNALSALRPEEIAALLSGLVCQSSGDPGDQLPSTLKQGVERVRAVAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATLLRRDIVFAASLYTQ
The following text describes a protein:
Function:
Required for normal flagella and striated fiber formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum basal body. Note=Localizes to basal bodies and the proximal ends of flagella.
Domain:
The coiled-coil domain is involved in microtubule-binding.
Sequence:
MGDICETVEATFHGVAYLLTVSTIEGETLCVEVEQKSDCSRWRGDFTSRYIEDITAKTGNFKKFPVFVKMLLSALKQASDSVFVDLLTYQDLEVLKSRKAGGQAPPPRTQPPNNKRYLIMTYAAEFDRVHYPLPLLFEENPDPQHLKRIISQLRSEVEGLQVEAGNRRGGEVSAELRRLREENAALQRQLKQMERSGSGVGAGAESSEARELARELRTVRKERDLLQARVEAAEAELERERGLHRRELRRRAKEQQELVDELGRCKEQIRELKMRIRQLTEDLEARDRRMNSTDRIRSVYARGSNDGSTSGVAPRRPSSGGRGPSSNYMAPTRGADSRSNSRGRGTSSAERSRPNSAPIGGPRPRFDPTEYVRQRKERESAAVGGRRSNAPTPPRSAGTSRASSVVGSRPASAERLPPIRTASPTNSRPSSTERYRPGSGGPPGRTSAGGSRGAADRAGARGPDPYAPRSRGASPSGRATAWGEPGASGGGAGGWSKFPGGGGGGVGGSGQRISSNSPRSMSPARALAEVKQKLSTFVAGRGGSLQGDDASSAHGEHMSQSSKSQVFEDATAEIADIDSRLHALQNFLRMAKTSSTSTSTTQA
The following text describes a protein:
Function:
Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTKLTQWLWGLALLGSAWAALTMGALGLELPLPCREVLWPLPAYLLVSAGCYALGTVGYRVATFHDCEDAARELQSQILEARADLARKGLRF
The following text describes a protein:
Function:
Regulates the expression of the Rv1217c-Rv1218c multidrug efflux system and its own expression. Acts by binding to promoter regions of Rv1219c and upstream of the Rv1218c gene. Important for survival in prolonged stationary phase and during macrophage infection. May be used to eliminate non-growing mycobacteria.
Domain:
Contains an N-terminal DNA-binding domain and a C-terminal ligand-binding domain, which can accommodate a variety of structurally unrelated antimicrobial agents. The C-terminal domain is also involved in dimerization.
Sequence:
MRSADLTAHARIREAAIEQFGRHGFGVGLRAIAEAAGVSAALVIHHFGSKEGLRKACDDFVAEEIRSSKAAALKSNDPTTWLAQMAEIESYAPLMAYLVRSMQSGGELAKMLWQKMIDNAEEYLDEGVRAGTVKPSRDPRARARFLAITGGGGFLLYLQMHENPTDLRAALRDYAHDMVLPSLEVYTEGLLADRAMYEAFLAEAQQGEAHVG
The following text describes a protein:
Function:
Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1.
Sequence:
MDNSSQSKPSSSSSSHSPSPAAITPTQRTTRDSGLCSTIDIPEIQAQCIDNLNSHYLGKGTYGLVEKTRYRKTRQDDFRPAAIKYSSQLHMATLIREAKVMWDLRNHPNIIKIYGLYKSPRNGQGVVMEYMDCGSMADLLYDRTHINYTIDHVASWMFQLSSAVDFFHSNSQVHRDLKLQNMLLSDRYRTMKLCDFGTFTSMHQSMTSNRGTPITMAPEVFRCEQYNMKSDIYSIGIIMWQIIARNHPYRRDLSVPGLLYNVATANLRPQELECNPILSEFYKKCWNDNADIRPTSSECVEYFTLLKDEYPNGSVPLSDSSTNGPAETPPPHAHRPTMLGTSSGSGIGSNNRTPTASKLLNPQQPGQGHRRNRSETFVVQPDLPYPTVPGEAGASRIPKSQSEAKNFRDRAKSEQRQPHRDARPPPPFEHRRDSNDEEKHAVFMNICSNEETRPIDPDTRDEKSLEIFHQHCDNNKQYADAWVIKKEVMRAKHELIAQWPQHDHTVELLERKYYLEQEIARYRDIQDDNYFSTERM
The following text describes a protein:
Function:
Crystallins are the dominant structural components of the vertebrate eye lens.
Sequence:
MGTSVGKILFYEDRNFQGRSYECSSDCADVHLQLSRCNSCRVDSGCFVVYERPSFTGNQIFLRRGEYPDFQRMGSALGMTGAAPMETVRSCRVIPMVRRGRPLLPLLAEAPPNAAGLSFPSAQRPVPHEDLRARELRRPDAGADGGLPVPAGALQHVRLPVLQRDGRPLAPVRAARLQRQDGVPEARRVPEPEGRVHQQHHAVQLGPARHGRLLMPAGVQGNR
The following text describes a protein:
Function:
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways. Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination; (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress.
Domain:
The leucine-zipper domain and the CCHC NOA-type zinc-fingers constitute the UBAN region and are essential for polyubiquitin binding and for the activation of IRF3.
Sequence:
MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
The following text describes a protein:
Function:
Negatively regulates mhqA, mhqED, mhqNOP, and azoR2 which may contribute to the degradation of aromatic compounds.
Sequence:
MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLYHKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLLNDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK
The following text describes a protein:
Function:
Contributes to the regulation of secretory and vacuolar transport pathways in the post-Golgi network, and to the maintenance of the Golgi apparatus and trans-Golgi network (TGN) morphologies. Vesicle trafficking protein that functions in the secretory pathway and mediates liposome fusion. Required for extracellular resistance responses to a fungal pathogen. Also involved in the protection of chloroplasts from salicylic acid-dependent biotic stress.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein.
Sequence:
MATRNRTLLFRKYRNSLRSVRAPMGSSSSSTLTEHNSLTGAKSGLGPVIEMASTSLLNPNRSYAPVSTEDPGNSSRGTITVGLPPDWVDVSEEISVYIQRARTKMAELGKAHAKALMPSFGDGKEDQHQIETLTQEVTFLLKKSEKQLQRLSAAGPSEDSNVRKNVQRSLATDLQNLSMELRKKQSTYLKRLRLQKEDGADLEMNLNGSRYKAEDDDFDDMVFSEHQMSKIKKSEEISIEREKEIQQVVESVSELAQIMKDLSALVIDQGTIVDRIDYNIQNVASTVDDGLKQLQKAERTQRQGGMVMCASVLVILCFIMLVLLILKEILL
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MRSSLLNFLFFTFIAAVAAVNERVLAIFDHEHADYESLLDSLRERDFDVTVKDVKAPDSSLFEFGERKYDDLLLFSARNKGLGASFSPKALIEFVEDGGNILLAAGTNVPEGLREFGRQLGIFVAERGNALVDHFASVGSEDHQLVALDEFSSSKYIVSDETRNAGAVLYKGSGHALGENPLVEPVLRAKTTSYLYNQKSESESSAHPWAAGSQLFVVSSLQTLNGSRVAFSSSLDIFKNEYLSPSSESYNAANALFARDLTNWVFQRSGRLVLENMTYGLISESVEERNGPVYRIKDEMEFTADMSVYENGVRKPYIASDVQMELVMLDPYYRLNFEPVESDLKDAQRYSVKLVAPDHYGVFSYKVRYSRPGLTNIDEKQTFTLRQFHHNEYPRFLPHAYPYYTSAFIVFVGFVMFAGAWLFFKPAAPSVKKQQ
The following text describes a protein:
Function:
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
Sequence:
MEKFILNVEKRERTGKGIARQLRSKGIIPCVIYKNGQSTPVQIPTKELYTFMNIATREKLFVTLKLDGQEKQAILQDYQVDPVTGKLLHVDFMEVSATEKIRVTIPVVLIGEPIGVKQDKGVLQHGISEIEIEAIPEKIPGHIEVDVSHLEVGDAVHVSDIKFEEGIKVISNPEEVIATVTVEEEEAEVAPSIEETVEPEVIKKGKKAEEEEEK
The following text describes a protein:
Function:
Transcriptional regulator acting as an intermediary between major regulators sarA and agr and virulence genes. Represses alpha-hemolysin (hla) gene expression. Down-regulates agr RNAIII expression by repressing sarU, a positive activator of agr expression. Up-regulates sarS, which induces the expression of the cell wall-associated protein A (spa).
Subcellular Localization:
Cytoplasm.
Sequence:
MNDLKSKSNIKLMKRVLTTYELRKYLKKYFCLTLDNYLVLAYLDVFKNDEGKYFMRDIISYIGIDQSRIVKSVKDLSKKGYLNKCRDPHDSRNVIIVVSVKQHNYIKNLLSEININET