lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway. May cleave double-stranded RNA to produce short 21-24 nucleotides (nt) RNAs which target the selective destruction of complementary RNAs.
Subcellular Localization:
Nucleus.
Sequence:
MGDAATAAVAADAAATEEAHKEDPEIVARWYQLEALERAMSGNTVAFLDTGAGKTLIAGLLLRAYAHRVRKPARDYAVFLVPTRVLVEQQARVIEAHTDLRVSKFTGDMGVDFWNAAIWRRVVDDAEVLVMTPQILLDNLRHSFFSLQDIALLIFDECHRAKGNSPYACILKEFYHPVMNSRPRGPLPRIFGMTASPTDSKNLLQESYSKRIVELENLLNSKVYTVDNESALSEYIPFATTRIVQYDDYIIPSNSHNHIKSCLDKLQEKHLEVLKANLHGLSRKNAKKGISKLHKAFLYCTANLGVWLAAKAAEIHSTTNEQFLSFWGEELDKNVEGFVRSYSEEVYRELSCFSKRGHIGEDFAADLQDGLLTPKVHCLVQFLLEYRHMQDLRCIVFVERVVTSIVLESLLSTINQMPGWIIKHIAGNRPMFHNQSRNKQTEIVDAFKGGKVHIIVTTQVLEEGLNVPGCHLVIRFDPPTTGRSFIQSRGRARMPNSDYVLLVRRGDAEAHSKTLKFLASGQIMREASLKLASTMCQPLEDTLLQEEYYRVESTGATVTMNSSVQLIYFFCSKLPSDEYFKPLPRFIIDKELRTCTLYLPNSSPVQAVNTEGEVSALKKAVCLKACRELHAVGALTDYLLPEFGFPCEEEPDIVVEKYQHEQPEYFPEEFVYNWLSFSRLGIYYCYKISVEGCLKTTYCPNDILLAVKCDLGPDFVSTSLKLFGEQDNASVAMKYVGIIHLNQEQVVMARRFQTTILSLLINKDHSEVINAVKYSHEMQVSIGIVYLLLPLVSGKVDWCSIKFSTSQVYDASNKDIRHCHSCKQVDLLQTKDGPLCRCMLQNSIVCTPHNSKFYAVNGFLDLNSKSLLHLRDGSALTYINYFNTRHGLSLTHENQPLLAARNPVEVRNFLQKRHYKNKKESRTSHGVELPPELCRLVMSPVSNNTLYSFSVIPSVMYRIQCLLLSAKLKDQLGPTMQQFAIPALKILEAVTTKECQEEFSQESLETLGDSFLKYVATQHLYGKYKLQHEGTLTKMKKNLISNAALCQLACSNNLVGYIQGEEFNPKGWIIPGLGYDMCGNSKISFLSSNDMHTLRKMSVRSKRIADTVEALIGAYLGAAGEQAAFVFLKSLGLDIEFHSNIPLERKIVLKSEKFINVRSLEMILGYEFKDTSLLVEALTHGSYQTAGATACYQRLEFLGDAVLDHLFTIYFYNQYPECTPELLTDLRSASVNNNCYAHAAAKAGLNKHILHSSLQLHGRMAYYFENFKQPFTGPSHGWEAGIGLPKVLGDVIESLAGAIYLDSKYDKEVVWKSMKQLLEPLATPETVERDPVKLLQEFCARRSYSSSYTKAHKDGVSSVVAEVQVEGTTYTATETGPDKIVAKKLAAKSLLNNLKAIVP
The following text describes a protein:
Function:
Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3. Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (By similarity). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (By similarity). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (By similarity). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (By similarity). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (By similarity). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions.
Subcellular Localization:
Lysosome membrane. Cytoplasm. Note=Colocalizes with FLCN in the cytoplasm.
Sequence:
MAPTLLQKLFNKRGGGAASAQARPPKEEPAFSWSCSEFGLSDIRLLVYQDCERRGRQVMFDSRAVQKMEEAAAQKAEDVPIKMSARCCQESSSSSGSSSSGSSSSHGFGGSLQHAKQQLPKYQYTRPASDVSMLGEMMFGSVAMSYKGSTLKIHYIRSPPQLMISKVFSATMGSFCGSTNNLQDSFEYINQDPQAGKLNTNQYNLGPFRTGSNLAHSTPVDMPSRGQNEDRDSGIARSASLSSLLITPFPSPSSSTSSSSSYQRRWLRSQTTSLENGIFPRRSTDETFSLAEETCSSNPAMVRRKKIAISIIFSLCEREAAQRDFQDFFFSHFPLFESHMNRLKGAIEKAMISCRKISESSLRVQFYVSRLMEALGEFRGTIWNLYSVPRIAEPVWLTMMSNTLEKNQLCQRFLKEFILLIEQVNKNQFFAALLTAVLTYHLAWVPTVMPVDHPPIKAFSEKRTSQSVNMLAKTHPYNPLWAQLGDLYGAIGSPVRLTRTVVIGKQKDLVQRILYVLTYFLRCSELQENQLSWSGNPSEDDQVINGSKIITALEKGEVEESEYVVVTVSSEPALVPPILPQGTAERRSPEPTVVAEISEGVNTSELGHKPEKNRCKRPEQNSEASSMGFQEAEPDSSWIPQGIFCEDKQNDQEATQDCSSSPPSCEVPRVRRRMDQQTLHSKLHGETLKKRAEQSAAWPCPDRHSQEDPPVEKVTFHIGSSISPESDFESRTKRMEERLKACGHFHGASASASSSMDTGLTQEQQGSGCSFKADFEKDITPQDHSSGGEGVSEDRGLRANMTHAVGQLSQVDGPLAHSLCAAESGRRLLEQTRDVQLKGYKGPSSEPVPNRCRQQGGLLIAADVPYGDASGKGNYRSEGDIPRNESLDSALGDSDDEACVLALLELGHSCDRTEESLEVELPLPRSQSTSKANVRNFGRSLLAGYCATYMPDLVLHGTSSDEKLKQCLAADLVHTVHHPVLDEPIAEAVCIIADTDKWTVQVATSQRKVTDTMKLGQDVLVSSQVSSLLQSILQLYKLHLPADFCIMHLEDRLQEMYLKSKMLSEYLRGHTRVHVKELSVVLGIESNDLPLLTAIASTHSPYVAQILL
The following text describes a protein:
Function:
Essential protein that may act as a regulatory protease that is conditionally activated upon appropriate environmental triggers.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Domain:
The periplasmic region consists of a protease domain (PD) and a PDZ domain, connected by a ten-residue linker. Interactions between the PDZ domain and the catalytic domain lead to an inactive conformation.
Sequence:
MDTRVDTDNAMPARFSAQIQNEDEVTSDQGNNGGPNGGGRLAPRPVFRPPVDPASRQAFGRPSGVQGSFVAERVRPQKYQDQSDFTPNDQLADPVLQEAFGRPFAGAESLQRHPIDAGALAAEKDGAGPDEPDDPWRDPAAAAALGTPALAAPAPHGALAGSGKLGVRDVLFGGKVSYLALGILVAIALVIGGIGGVIGRKTAEVVDAFTTSKVTLSTTGNAQEPAGRFTKVAAAVADSVVTIESVSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPSQFKTTVVFNDGKEVPANLVGRDPKTDLAVLKVDNVDNLTVARLGDSSKVRVGDEVLAVGAPLGLRSTVTQGIVSALHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDAQVIGINTAGKSLSDSASGLGFAIPVNEMKLVANSLIKDGKIVHPTLGISTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIVKVGNRAVADSDEFVVAVRQLAIGQDAPIEVVREGRHVTLTVKPDPDST
The following text describes a protein:
Function:
Promotes the invasion of pathogenic bacteria into eukaryotic cells by an unknown mechanism.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKKTLLASSLIACLSIASVNVYAASESSISIGYAQSHVKENGYTLDNDPKGFNLKYRYELDDNWGVIGSFAYTHQGYDFFYGSNKFGHGDVDYYSVTMGPSFRINEYVSLYGLLGAAHGKVKASVFDESISASKTSMAYGAGVQFNPLPNFVIDASYEYSKLDSIKVGTWMLGAGYRF
The following text describes a protein:
Function:
Binds the phosphorylated C-terminal domain (CTD) of the largest subunit of RNA polymerase II and functions as a scaffold for RNA processing machineries (Probable). May be involved in pre-mRNA splicing (Probable).
Subcellular Localization:
Nucleus.
Sequence:
MEGENTTDPPYTTAASSGQSIFVRPPPIAPVLATTSNFSQSELKELHSMSIASTGFVSQSVPYSVTAQWGTNAAASSNVNPIPQASPMLANAPFGRPGTLAPPGLMTSPPAFPGSNPFSTTPRPGMSAGPAQMNPGIHPHMYPPYHSLPGTPQGMWLQPPSMGGIPRAPFLSHPTTFPGSYPFPVRGISPNLPYSGSHPLGASPMGSVGNVHALPGRQPDISPGRKTEELSGIDDRAGSQLVGNRLDAWTAHKSEAGVLYYYNSVTGQSTYEKPPGFGGEPDKVPVQPIPVSMESLPGTDWALVSTNDGKKYYYNNKTKVSSWQIPAEVKDFGKKLEERAMESVASVPSADLTEKGSDLTSLSAPAISNGGRDAASLKTTNFGSSALDLVKKKLHDSGMPVSSTITSEANSGKTTEVTPSGESGNSTGKVKDAPGAGALSDSSSDSEDEDSGPSKEECSKQFKEMLKERGIAPFSKWEKELPKIIFDPRFKAIPSHSVRRSLFEQYVKTRAEEERREKRAAHKAAIEGFRQLLDDASTDIDQHTDYRAFKKKWGNDLRFEAIERKEREGLLNERVLSLKRSAEQKAQEIRAAAASDFKTMLREREISINSHWSKVKDSLRNEPRYRSVAHEDREVFYYEYIAELKAAQRGDDHEMKARDEEDKLRERERELRKRKEREVQEVERVRQKIRRKEASSSYQALLVEKIRDPEASWTESKPILERDPQKRASNPDLEPADKEKLFRDHVKSLYERCVHDFKALLAEALSSEAATLQTEDGKTALNSWSTAKQVLKPDIRYSKMPRQDREVVWRRYVEDISRKQRHENYQEEKQRDYKT
The following text describes a protein:
Function:
Positive controlling element of AmiE, the gene for aliphatic amidase. Acts as a transcriptional antitermination factor. It is thought to allow RNA polymerase read through a rho-independent transcription terminator between the AmiE promoter and gene.
Sequence:
MSANSLLGSLRELQVLVLNPPGEVSDALVLQLIRIGCSVRQCWPPPESFDVPVDVVFTSIFQNRHHDEIAALLAAGTPRTTLVALVEYESPAVLSQIIELECHGVITQPLDAHRVLPVLVSARRISEEMAKLKQKTEQLQERIAGQARINQAKALLMQRHGWDEREAHQYLSREAMKRREPILKIAQELLGNEPSA
The following text describes a protein:
Function:
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
Subcellular Localization:
Cytoplasm. Mitochondrion matrix.
Sequence:
MVLGRRLLGRRSFAALGAVCARRGLGAAFLGSILRQAEVRKSLMVEEGSMKVELLPALTDNYMYLIIDDDTKEAAIVDPVQPQKVVETVKKHGVKLTTVLTTHHHWDHAGGNEKLIKLEPGLKVYGGDDRIGALTHKVAHLSTLQVGSLNVKCLSTPCHTSGHICYFVTKPNSSDPPAVFTGDTLFVAGCGKFYEGTADEMYKALLEVLGRLPPDTRVYCGHEYTINNLKFARHMEPNNAAIQEKLAWAKQAPRQGRSCRSPACFPRPGLHGLEGPCGTTSASLSGETAPALSSEWRNSPGGCLSARHLFQPGLPMCWHPLCCAAQPRAWLGVLEASSVGVWECCCGWLG
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MQLFVTLNLSSHSRLRFFESFCSSLSHCARDPRREKMEGTRAGTATGSYKCGKPGHWLRDCPFSAPNSNFNLNPNPNSITATTPNPNTPNRSSSSFKPKSATKKPNMLPRTKPKLTPELLLSDDDLGYALRYFPRKFKYCGRGHEFVHKVEKVAATRRGKSMDILQVLVESGTSETLLISYAYFIFLYRAIYVKSILRVFFPLILLVWHIKKDTRGAMSCLHCLWTCASKVYKLPFP
The following text describes a protein:
Function:
Regulates the expression of the fruBKA (fru) operon, which encodes proteins involved in the import and metabolism of fructose. In the absence of fructose 1-phosphate (F1P), binds to the promoter region of fruB, interferes with the binding of the RNA polymerase (RNAP) to the promoter and represses the expression of the operon. In the presence of F1P, activates the transcription of the fru operon by facilitating the binding of RNAP to the promoter. Essential for the expression of the fru operon and thus for growth on fructose.
Sequence:
MTLDEIAKLAGVSKTTASYVINGKAQKYRISEKTQHKVMAVVEQYNFRPDHAASALRAGNSRSFGLIIPDLENTSYARLAKLLEQNSRQAGYQILIACSDDDPQIEMAAAEALVSRRIDALFVASGIPSASEYYLKLQQSGTPVIAIDRALDDEYFSCVISEDFGAAFELTRSVLTQDVHSVGLVGALPELNVSREREQGFAMAVKQRGLPTTLGYGEHFNREEGRKVFAKWVANDQLPDAVVATSYTLLEGILDVLLEQPELMQKVRLATFGDNRLLDFLPIRVNSLPQQFELIADSALALALNASAKRYQTGIELIPRQLKVRT
The following text describes a protein:
Function:
Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the mei-3/rad51 recombinase (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPAVGDQHKLIANPFEEPQRRISEYTAQEIATLQSRLEKQLGPEYLSSRAGPSGQKVHYISSEKCIQLANEVFGFNGWSSSIQNIQVDFVDEHPQTLKINMGISVIMRVTLRDGTYHEDLGYGHIENCKGKAAAFEKAKKEATTDALKRALRQFGNVLGNCIYDKQYLAKVTKMKVEPTKFAEDNLHRHSDFVKKEPVEADIMKVDSVGAGARPPALGNEESFEDLLGELDEADFNMADEGHPDEVVLPQAVHNSLNDKPVHQQLTNLNPQAQQSRPLSRSGSTGSLNTRQQPQNSHQFTARAQSRPPQQQLNSNQSRPMGQPVNNSSNANTPNNPQNYTTPQKPAPAAPAPQAGAAVAPAPETVGFFSAKAVTQLPEEALASGQVAPKPGLAFNPHAESPSIRKTPGIDHTKSKPLARNGQHVPPAKTTETEAEPSTSLSRPAGAHAASRPVTMNEARSASGSFSRAGPPMGGNAGNMGKPNVVNPQLDHTRRIGAPGMSGFSSSPSTNRGQYRPLTMKRPAPVVGGGAGQTKDGNGDSATTTTIAANTTAGSATGGNAAPSAGNGGRVPLTDMSANASNATAAGAATSGPEVKRQRLA
The following text describes a protein:
Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. DNA glycosylase that recognizes and removes damaged pyrimidines. Excises Tg:A (thymine glycol, prefers 5R isomers), Tg:G, 5,6-dihydrouracil:G base pairs and urea:A, also excises oxidized purine derivatives guanidinohydantoin:C and spiroiminodihydantoin:C. Poorly cleaves dsDNA with uracil substitutions, thus also acting as a weak uracil-DNA glycosylase. Acts on DNA bubble and 3'-fork structures, suggesting a role in replication-associated DNA repair. Activity on 7,8-dihydro-8-oxoguanine (8-oxoG) is debated; a report shows weak activity , whereas another shows none. Has AP (apurinic/apyrimidinic) activity and introduces nicks in dsDNA strand, inefficiently cleaves ssDNA with AP sites and uracil. Probably cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Cleaves ssDNA containing an AP site. Complements an E.coli fpg mutY but not nei nth double mutant.
Sequence:
MPEGHTLHRLARLHQRRFAGAPVSVSSPQGRFADSASALNGRVLRRASAWGKHLFHHYVGGPVVHVHLGLYGTFTEWARPTDGWLPEPAGQVRMRMVGAEFGTDLRGPTVCESIDDGEVADVVARLGPDPLRSDANPSSAWSRITKSRRPIGALLMDQTVIAGVGNVYRNELLFRHRIDPQRPGRGIGEPEFDAAWNDLVSLMKVGLRRGKIIVVRPEHDHGLPSYLPDRPRTYVYRRAGEPCRVCGGVIRTALLEGRNVFWCPVCQT
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEWLIFFILGAWLIISALGTVLAKNPIHVMLFFLSSLLAMAGLFLSLGAELLAGLQLIIYAVAIVVFYVLAITTIPWEKIKRFEGVYKTEILTASPILLVLFLVMSYMVIKGKFAEPSGVVKDNVEAVGRTLFTSYLFPFEVASVILLVAMVGAILLARKEE
The following text describes a protein:
Function:
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
Miscellaneous:
MISCELLANEOUS: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MDIKEIALGQIRDSIATKQKCIDSILEDIIKAGEIVSKILQAGNTIFLCGNGGSSCDASHIAAELVVRYKSGNERKALPALSLSADSAVLTACSNDYGYEEIFSRQIEAFGRKGDLLIGLSTSGNSKNVLLALEKAKTRGVKTISLLGGDGGKMKNLSDLDVIVPSNVTARIQESHILIGHIICSIVEYNLFKME
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MGRQEKTDMSSTGTSINYKLQNLFKVLTYEKEAAPGMLGASVFGTNDIYKRWTDFVVKRKAAGCTDPLYFVKVDIQHCFDSIPQDKLLEVMASVLSRGCDYLIRRYAKVVATRKNVQCTFEKHIAVLDDFIPCFKAFVLLQNQSGKMYDAIAVDQVIQHHASPTVMLRQLQHHVQNNVIQIGGSYYRQISGISQGSCLSTLLCSFFYADMERRHLCGMDTDGLLLRLVDDFLLVTPHLDQATAFLCTMLDGIPDYGCSVHPDKVLTNFPVQHRNAVVTCQPAVGWFPWCGMLFHTLLLGVMRDYTKYANLSIRYTLTFDLHQTPGQAMKQKLINTVKAKCHAFFLEPKVNSAAVIQQTLYKAFLFTAHQFHSYNSCLPSRCRAQDNPAFFLTMIMDICHYPLLLVDAMVAKEVMSGQLPVSQDAVEWLCLQAFKSKLSSHRSVYFSLLKRLEKCIRTLEKNLDCKELQQVTSQQSVAEFQSILA
The following text describes a protein:
Function:
Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MQKYIVEARSLLALAIPVVIAQLSQTAMGVVDTIMAGSVSATDMAAVAVGTSIWLPAILFGHGLLLALTPTVAQLNGSGRRSQIAHQVRQGFWLALCVSVLIMLVLYNSDHVIKQMDNIDPVLAQKAVGFLHAIMWGVPGYLFFQVLRNQCEGLSKTKPGMVIGFVGLLVNIPINYIFIYGKFGAPALGGVGCGVATASVYWVMFLMMRWYVTRARSQQDIKLEKGFAAPDWQVMKRLSGLGLPVALALFFEVTLFAVVALLVSPLGIVAVAGHQIALNFSSLMFMLPMSLSVAATIRVGFRLGQGAVEQAQVAAYTSMAVGLLLASVTAVFTIVFREHIALLYNKTPEVVTMASHLMLLAALYQLSDAVQVIGSGVLRGYKDTRSIFFITFTAYWLLGLPSGYLLGLTDYILPAMGPAGFWIGFIIGLTAAAILMVLRIRWLQKQPTAFILQRAAH
The following text describes a protein:
Function:
May play a role in the spatial distribution of the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation, perhaps being involved in cytoskeleton dynamics. This subunit is directly targeted to the BMC (By similarity). Might bind GTP (Probable); The 1,2-propanediol (1,2-PD) degradation bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
Miscellaneous:
MISCELLANEOUS: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate. BMCs can constitute up to 10% of total cell protein.
Subcellular Localization:
Bacterial microcompartment. Note=Probably found on the exterior of the BMC.
Sequence:
MKRLMFIGPSQCGKTSLTQSLRGEALHYKKTQAIEWSPMAIDTPGEYLENRCLYSALLTSACEADVIALVLNADAQWSPFSPGFTAPMNRPTIGLVTKADLAEPQRISLVAEWLTQAGAQQIFITSALNNSGLDAVLDFLNSKEPLCLTK
The following text describes a protein:
Function:
Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils.
Miscellaneous:
MISCELLANEOUS: Has no murine ortholog; MISCELLANEOUS: [Isoform 3]: Due to a 40-nucleotide deletion (nucleotides 439-479) resulting in a frameshift leading to a premature stop codon and the production of a truncated soluble form.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein; [Isoform 3]: Secreted.
Sequence:
MQGPLLLPGLCFLLSLFGAVTQKTKTSCAKCPPNASCVNNTHCTCNHGYTSGSGQKLFTFPLETCNDINECTPPYSVYCGFNAVCYNVEGSFYCQCVPGYRLHSGNEQFSNSNENTCQDTTSSKTTEGRKELQKIVDKFESLLTNQTLWRTEGRQEISSTATTILRDVESKVLETALKDPEQKVLKIQNDSVAIETQAITDNCSEERKTFNLNVQMNSMDIRCSDIIQGDTQGPSAIAFISYSSLGNIINATFFEEMDKKDQVYLNSQVVSAAIGPKRNVSLSKSVTLTFQHVKMTPSTKKVFCVYWKSTGQGSQWSRDGCFLIHVNKSHTMCNCSHLSSFAVLMALTSQEEDPVLTVITYVGLSVSLLCLLLAALTFLLCKAIRNTSTSLHLQLSLCLFLAHLLFLVGIDRTEPKVLCSIIAGALHYLYLAAFTWMLLEGVHLFLTARNLTVVNYSSINRLMKWIMFPVGYGVPAVTVAISAASWPHLYGTADRCWLHLDQGFMWSFLGPVCAIFSANLVLFILVFWILKRKLSSLNSEVSTIQNTRMLAFKATAQLFILGCTWCLGLLQVGPAAQVMAYLFTIINSLQGFFIFLVYCLLSQQVQKQYQKWFREIVKSKSESETYTLSSKMGPDSKPSEGDVFPGQVKRKY
The following text describes a protein:
Function:
May be required for cytoplasm to vacuole transport (Cvt) and pexophagy.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Note=Endosome and other perivacuolar punctate structures.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.
Sequence:
MSTDNLFEDIEQDNNPSFYGNPSILNDPYRPIQPPPPQQQQQQHQENESKQSHTKSPKPPLQSIHSGTSNAHPQSQPQHKHKHKHNTSLNNGYPNELVNSTIGLSNRILELLNDSQLQVDIINSEKLVNSSVIVYTIELSSPTTKIVVKRRYSEFKSLRDNLLKLFPTLIIPPIPEKHSILSYLLNTINHSHEISIIEMRKRYFKMFLDDLIFQSDYKLKNCPLLHKFFDPNYELCWYNALNEPPVSLIPDNLLLANPINPADQNGLYSLLPIVNGFDFNSHIDNLSNLKKINEDLYKLNDQVKLYELKGFEQDLEFSIPEELIQFEIKFHQTIKILTDLNKLNSKTTKNYKSMVDTLIDLGGNLNNFSLQVYQQKSGSNNELSEAIEKFGSTMDQSFLNFESFILNQLVPQWQEPVDQLILYLQNSLGLIKFYKYKIVQFKILYKLKFNKFQQLINLTNIGGVSSSGSGGGGLLASRISTDNDSNNSNNSGNNNNDGDLDTENFDHLKELNSPTINNALKNLSTKKISKKSSWYGLFGGNNQTKKFNFQLPIEEPTTATGSTEQQSQQQSAPNSPQREQQQQQSQSQSHHSHQTSIRFKLNHIEKELNKLNQLIELCNQDMHKLTEALVNTFEEFLSKIERKWLQLMITYIQNCKNMFEANLTNWKEFKESLVNETREVN
The following text describes a protein:
Function:
Catalyzes the formation of tuberculosinyl diphosphate from geranylgeranyl diphosphate (GGPP). It could also react with (14R/S)-14,15-oxidoGGPP to generate 3alpha- and 3beta-hydroxytuberculosinyl diphosphate.
Sequence:
METFRTLLAKAALGNGISSTAYDTAWVAKLGQLDDELSDLALNWLCERQLPDGSWGAEFPFCYEDRLLSTLAAMISLTSNKHRRRRAAQVEKGLLALKNLTSGAFEGPQLDIKDATVGFELIAPTLMAEAARLGLAICHEESILGELVGVREQKLRKLGGSKINKHITAAFSVELAGQDGVGMLDVDNLQETNGSVKYSPSASAYFALHVKPGDKRALAYISSIIQAGDGGAPAFYQAEIFEIVWSLWNLSRTDIDLSDPEIVRTYLPYLDHVEQHWVRGRGVGWTGNSTLEDCDTTSVAYDVLSKFGRSPDIGAVLQFEDADWFRTYFHEVGPSISTNVHVLGALKQAGYDKCHPRVRKVLEFIRSSKEPGRFCWRDKWHRSAYYTTAHLICAASNYDDALCSDAIGWILNTQRPDGSWGFFDGQATAEETAYCIQALAHWQRHSGTSLSAQISRAGGWLSQHCEPPYAPLWIAKTLYCSATVVKAAILSALRLVDESNQ
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGRELQKAKNKSSIPKKRQKGPSKKKILQNPIIAKHWNQKETLSQNYRRLGLTSRLNHATGGQEKTIALLGLNDPKSSRADIAAGSTANALNIVSKAPQTIDVEELEVERDPETGAILRVIGQKEETANPLNDPLNELDDDEADEWDGFAMVPEHGEQEQVNPVIRELEEAAKNGERKAPRKQSQREEEWLERLVARYGDDYGRMARDRKLNPMQQTEADIKKRVKKWQASQASQA
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Sequence:
MAKLKVNPTRMALSELKKRLVTARRGHKLLKDKQDELMRQFINLIKENKKLRVEVEKELSDSFKSFLLASATMSPLFLESAISFPKEKIAVEMKLKNIMSVNVPEMKFVKEEMEGSIFPYGFVQTSAELDDTVIKLQKVLDNLLSLAEIEKSCQLMADEIEKTRRRVNALEYSTIPNLEETVKDIRMKLDENERATITRLMKVKQMLQKDA
The following text describes a protein:
Function:
Adhesive protein that mediates cell-to-cell interactions. Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins. Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation. Plays a role in modulating pulmonary endothelin EDN1 signaling. Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging. In response to THBS1, negatively modulates wound healing (By similarity). Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWPLVAALLLGSACCGSAQLLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTELTREGETIIELKYRVVSWFSPNENILIVIFPIFAILLFWGQFGIKTLKYRSGGMDEKTIALLVAGLVITVIVIVGAILFVPGEYSLKNATGLGLIVTSTGILILLHYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLLISGLSILALAQLLGLVYMKFVASNQKTIQPPRKAVEEPLNAFKESKGMMNDE
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MHELFLSASVDSEDVSRALRILQGYCGMIPQPFIRRRLVFEGPRSRTNLKGLDPSFLKKQPPNKQFWWKNLNDQLIRQSYVLTLIYDVDRSQFGQPAKELGSGEDKSGLLPCDEVPGTLRWNDLPDPANAAIVNSRMFIAIDNEKSLCKLLQDSNHRFTREIIQECHRTVHNNIVFTLSRYFEVPSEFQEVDGNSRPKVNSRLPPFELLEPFDAEDKWILTASVEVQNGSDPDHMKSAMAELSGVQEEFRGCFALKAADRHTFDTKVKVQS
The following text describes a protein:
Function:
The main replicative DNA helicase, it participates in initiation and elongation during chromosome replication. Travels ahead of the DNA replisome, separating dsDNA into templates for DNA synthesis. A processive ATP-dependent 5'-3' DNA helicase it has DNA-dependent ATPase activity.
Sequence:
MAAKKPTNKMTEPRDRQMEGLKLPPHSLEAEQSVLGGLMLDNERWDNVSERVASKDFFSRPHRRIFTEMQRLLENSKPIDLITLSESLEQKGDLDSVGGFAYLAELSKNTPSAANIGAYADIVRERAVVREMISVANEIADAGYDPQGRSSEDLLDLAESKVFQIAESRASKDEGPKSVDRILEDTVARIEQLYQRPHDGVTGVSTGFTDLDKKTAGLQKSDLIIVAARPSMGKTTFAMNLCENAAMMQDKPVLIFSLEMPGDQIMMRMLASLSHVDQTRIRTGQLDDEDWARISSTMGILMEKRNMYIDDSSGLTPTEVRSRARRIFREHGGLSLIMIDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELQVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYHENSDEKGIAQIILGKQRNGPIGSVRLKFNGQWSRFDNYAGPQYDDE
The following text describes a protein:
Function:
Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions and plays a role in septation.
Miscellaneous:
MISCELLANEOUS: Present with 24700 molecules/cell in log phase SD medium.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MKLSATTLTAASLIGYSTIVSALPYAADIDTGCTTTAHGSHQHKRAVAVTYVYETVTVDKNGQTVTPTSTEASSTVASTTTLISESSVTKSSSKVASSSESTEQIATTSSSAQTTLTSSETSTSESSVPISTSGSASTSSAASSATGSIYGDLADFSGPYEKFEDGTIPCGQFPSGQGVIPISWLDEGGWSGVENTDTSTGGSCKEGSYCSYACQPGMSKTQWPSDQPSDGRSIGGLLCKDGYLYRSNTDTDYLCEWGVDAAYVVSELSNDVAICRTDYPGTENMVIPTYVQAGDSLPLTVVDQDTYYTWQGLKTSAQYYVNNAGISVEDACVWGSSSSGVGNWAPLNFGAGSSDGVAYLSLIPNPNNGNALNFNVKIVAADDSSTVNGECIYENGSFSGGSDGCTVSVTAGKAKFVLYN