lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the Preiss-Handler pathway, which is a recycling route that permits the salvage of free nicotinamide (NM) and nicotinic acid (Na) involved in the NAD biosynthesis. Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP. It is not able to use nicotinamide. PncB1 contributes to basal NAD level.
Sequence:
MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRYGVVAGTGRLLEALPQFRFDADACELLAQFLDPATVRYLREFRFRGDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAAGGRPLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEALGPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIVVSGDLDEFSIAALRGEPVDSYGVGTSLVTGSGAPTANMVYKLVEVDGVPVQKRSSYKESPGGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTLPLVRAGQPVADTSLAAARQLVASGLRSLPGDGLKLAPGEPAIPTRTIPA
The following text describes a protein:
Function:
Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWRFWIKVIISRLLLPVCIGPSFPNGTCTVMNVRLVNGYHDCEGRVEVNDGSSWVGVCKDLWDKKDATVVCRELGCGRAQFITGNFGQGKSEKQISKVQCSGNETSVLQCEKIQEFCYGSDAAVVVCSENARKQVKNCRDHLKEIKSTNFTYDFLSIYCSNSSETKNEPQKVIGLLSSFLKKLEIISNLTKEERTTAGEIILQSVENIELTVSANFDEFMKKNKSDDKLALEWLVIPANFTQKIEPLQIYGNTLQVNLQSPIQNTTQGNTAVLFASYTGLESVLDGRFFQSNSSEDTISPQINSHIVTVVIKQKNNHNYKCFQPINVTFQNKQKRSNKNVLFCVYWKSEGNESSWSKTGLKVIHSNETHTVCSSDHLSSFAVIMATNSKQINEDSVLSIISYVFVITALICLSLAIITFVFCKSVHKGHNIIHLHLSLCLFMAHLLFLTGGSKTDHNVICAVIAGVLHFFFLASFVWMCLEGVQLLLLVTNLRVVKYSSRSRLTKRYLLPPGYGIPAIIVAVSAGVFPGGYGTQTSCWLSYERGFNWSFHGPVSFLISVNIILFTIILWALRSQLGFLNTDISRVRNTRLLTFKSMAQCFIMGCSWILGFFQDAMFFKYAFVIINSLQGPFIFLVHCVLSQQIREEYRRWLRCTRRQKEKSESSGITMRTFEETSTKEHEPK
The following text describes a protein:
Function:
Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins. Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation. MSRB family specifically reduces the MetSO R-enantiomer.
Sequence:
MAARAALRSVPGSTNLHPTAAPKPFSQFPAIFRISRADKFGSHRRRSSARAMGSSSSSQRPDQVQEPANVNPASLSDEEWKKQLTNEQYYITRQKGTERAFTGEYWNTKTPGTYHCICCDTPLFESNTKFDSGTGWPSYYEPIGNNVKSKLDMSIIFMPRTEVLCAACDAHLGHVFDDGPPPTGKRYCINSASLKLKPK
The following text describes a protein:
Function:
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MLESDSSVKEFFTISRVYGAYYEIYSSKRGIVRAFLRGRLRTVAAQERHPFVVGDKILAEFSTGKDWVICERLERSSFLTRKSREGDTQVLCANVDQTAVLASLKSPETKDGFLDRCLAAVFTSGTQPLILFTKLDLVSKVEAENRMKVYRNLGYKVLGISCTTGQGIPELQKYLHGKMTFLVGNSGVGKSTLINLLTQTQVQKTSGISISKDKGKHTTTNSLLLILEDGTALIDSPGIKEWGILHLKKEEILESFPELSSQKKYCEEPNCCKLSSDCAMLSALEKEVLTSERKKSLESMLTSLDNPHRVTRRDRISK
The following text describes a protein:
Function:
Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds. May play a role in storage protein biogenesis (By similarity).
Sequence:
MDLAPGRRARLLVALALVVLVALAARSGAEVITLTEETFSDKIKEKDTVWFVKFCVPWCKHCKNLGTLWEDLGKVMEGADEIEIGQVDCGVSKPVCSKVDIHSYPTFKVFYEGEEVAKYKGPRNVESLKNFVSDEAEKAGEAKLQDS
The following text describes a protein:
Function:
May be involved in membrane protein folding.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MVKRRLSAFGNAFLIYFIIFRLCCCSPQTSHWCKYPALCLKSPDTHNENLVCDAYLSVIATKSEEKEASNPTTWDFTPTNKYQEPSFHTKTSLNGSDTISSNFLSKYEYSNGTSTSEFIDSISPPLVNETSTISSSKKLEQNYSVTEVIDTNIITSSSVTLPISEDGSSTSAAATIDSNIDEKTVAFSEEKRFNFASTDCAAAVIKTNPEAVGSSSILTENKDKYMLNKCSAENKFVVIELCEDIYVDTVQIANFEFFSSIFRDFKVSVSGKYPKYESSWMELGTFTALNLRTLQSFHIENPLIWAKYLKIEFLTHYGSEFYCPVSLLRVYGKTMIEEFEEANEDFLEQKVNDGSAIKADEIRKPQESPIFVDEEDTDVQSKPVRKNPSVELNSTDTLLSSTVISKSLSTVVIGNETGKSESYPATSTRSFNDISPSSSSSYSTAQISTFPSNQESIYKNINKRLSTLEERKKAFDEIVEKILTNYGKHNAKNMNFTQLLHELNSTLQLEISKLSKSVVKPSLFALQAKLELLSAENEYFQSQITSLYQESSFQKRLLMLQLTVLIVLTVYMAVSRLPENLPTTRSSSNNPIEASRPPFSRDEQDISKANDFRVSASSAVYTVGPELLQRKKRDPNTSIRSIHEREQDKIIHSRSHSVC
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Sequence:
AVKCNSDPVVLRTLNSQGVNFDCSNKGEIKVVLDMGVTPDRVVYANTVKCTSHLRFAEKHGVTLMTFDSEEELSKINDKNARLLLRIAASEYGSHQTMNAKYGSYPHEVEKLMKLAFFKGLNIVGVSFHVGCSFTHTEIFAQTIAEARGVFDSGARIGFSMTLLDIGGGFPGGVRKLERFKQVAETIKCAIDEHFPLSSGVKIIGEPGQFFVTSAYTLVTKVIAKRRKDVTIDGVAHRHENIFINESKYNCIPRDLYPFMDITYKPLSPPHDRPREVLTTLWAATCNPMDCILDKQPFFEVDVDEWMLMDNMGAYTLVL
The following text describes a protein:
Function:
Part of the ABC transporter complex OppABCDF involved in the uptake of oligopeptides and of the ABC transporter complex MppA-OppBCDF involved in the uptake of the cell wall murein tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate. Probably responsible for the translocation of the substrate across the membrane (Probable). Plays an important nutritional role and is involved in the recycling of cell wall peptides.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLKFILRRCLEAIPTLFILITISFFMMRLAPGSPFTGERTLPPEVMANIEAKYHLNDPIMTQYFSYLKQLAHGDFGPSFKYKDYSVNDLVASSFPVSAKLGAAAFFLAVILGVSAGVIAALKQNTKWDYTVMGLAMTGVVIPSFVVAPLLVMIFAIILHWLPGGGWNGGALKFMILPMVALSLAYIASIARITRGSMIEVLHSNFIRTARAKGLPMRRIILRHALKPALLPVLSYMGPAFVGIITGSMVIETIYGLPGIGQLFVNGALNRDYSLVLSLTILVGALTILFNAIVDVLYAVIDPKIRY
The following text describes a protein:
Function:
Together with RPP13L4/ZAR1, involved in the ambient temperature (above 22 degrees Celsius)-sensitive aerial organ development. Together with RPP13L4/ZAR1, involved in the regulation of the ambient temperature-sensitive intersection of growth and immune response in the absence of pathogens, by repressing the transcription of SNC1. Probable non-functional kinase required for recognition of the Pseudomonas syringae type III effector HopZ1a by RPP13L4/ZAR1 and, together with SZE1 and SZE2, to trigger subsequent defense responses. May function as a decoy to trap HopZ1a in the ZAR1 complex for recognition by the plant immune system.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Cell membrane. Note=Associates with the plasma membrane in the presence of the Xanthomonas campestris effector XopAC/AvrAC.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MSKNNKKKRRWDLKNGGILLEELIASFDGKTNPIRCFSSDQILKATDNFSESRIISSWGYFIWYKGVIEERQVSIKKWSSQNLSSFTEAYRDISVSSQMSGHKNALKLIGCCLEFDLPALVCEYTEHGPLNRDGGLSSGVVLPWKVRLKIAKEIASSVTYLHTAFPETIVHRNINPTNIFIDENWTAKLSDFWFCVAIPEGELYVEDDVKGVIGFVDPDYYWTMKVTEKVDIYSFGVVMLVLLSGRAAVFNGPDEAPMSLNDHVSEVMEKGEFDEIVDKEIWNDLGGDDDLVLRRSQVKAFLRLALRCVRYKKEDPVSGMLEVAKELKLIEKLS
The following text describes a protein:
Function:
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MKELKELLDQIQQTTYSQLTSAAVKEVSSQLHTKGTSSSEIKHVLQGINERQQDTLMKVLYFCLDRDAKNSKTYLLWHAELHNITGTGSILRVMAEKNKNYDAQNKSNEKK
The following text describes a protein:
Function:
Appears to perform a very early function in establishing the identity of a subset of cells that originate in the region of the ventricular zone in the developing spinal cord and in the hindbrain.
Subcellular Localization:
Nucleus.
Sequence:
ESNSKARRGILRRAVFSEDQRKALEKMFQKQKYISKTDRKKLAINLGLKESQVKIWFQNRRMKWRNSKEKEVLSNRCLQEGLQENYLSQSAMNFASPCPSVWEVSQEQTSPRWKEKSPGNSERLTSTQPPPRANSSQSPLYLYPDHDTANKAVTSSD
The following text describes a protein:
Function:
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
Sequence:
MRIVFGGSFDPVHVGHIILARDVCEHFNAKEVIFVPTYQAPLKEKHKASAQDRLNMLKLALEREEKFTIEDYEIRRKGISYTVYTLKYLKEKYGGEELYLLLGSDSFLKFHKWKEPREILKLAKIIVVEREGMLEKVKEYIKEYFPELRKNEDIFFYKGRRIDISSTE
The following text describes a protein:
Function:
Zinc chaperone that directly transfers zinc cofactor to target proteins, thereby activating them. Zinc is transferred from the CXCC motif in the GTPase domain to the zinc binding site in target proteins in a process requiring GTP hydrolysis.
Sequence:
MKKTKVHLISGFLGTGKTTALKSLMAQKDPNEKWVIIVNEFGEIGIDGAVLSDNGIPVAEIAGGCLCCTAGPQMGVTVQKMLRDAKPDRLMIEASGLAHAASVIDELKTKPLDSLLEIGAVFTVVDPRQFINPDYAQQALYKDQIGICDVLVASKTDLCTPEQLAEFHDKAAKLFPPKAKVVEVQNAQLDIQWLDIPVIEKSRYRLKALPDNTMGFQSQGFTFPAGRDFDGEKLTNFFNDLPNMTEGLVRAKGVFQVLGTWVWLNWVDGQWGANQVSWRRDSRFELIAKSFDADLIEQKLKDALE
The following text describes a protein:
Function:
Zinc chaperone that directly transfers zinc cofactor to target proteins, thereby activating them. Zinc is transferred from the CXCC motif in the GTPase domain to the zinc binding site in target proteins in a process requiring GTP hydrolysis.
Sequence:
MISAFVVTGFLGSGKTSLIINSVKEHLKDKKVAIVVNEFGEVGVDGKILKNVYSEVLELSEGCICCKLSAEFESSVRRLIQDYNPEVLIVETSGVAEPFPIVFSLKTLGLFVDGVICVIDSKNFPKYKEDDTAKYQLATSNVVVLNKTDLVSKEELEKVKEEVKKIKEKYKVVNMFSPEEKESFYKIYEATYGKVPAEVFKGVGKPVELKEHLHFHSHDSRKEEVVTFDRELTEEELVNFLKNLPKEVIRAKGIVKLKDYPFPVFVHYVFGDYDYGMPAENYEGESFLVLIR
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MDSVIVRMGRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEFCSSSRYNIYMDICTDSFMYRMEYGNGITFFVSSIRICFRSKQAARTGMDRSQFHLIGLPGSFHCNFDFHAENTGEVSKMQLWSTRVKCLCKGSTNSYKHYR
The following text describes a protein:
Function:
Catalyzes the attachment of tryptophan to tRNA(Trp).
Subcellular Localization:
Cytoplasm.
Sequence:
MRIVSGMRPTGKLHLGHYFGVIRNWVKLQEEHECFFFIADWHALTTAYKNTKELRQNIREVMIDWLALGLDPQKSVLFIQSLVKEHAELFLLFGMITPKSWLELNPTYKDLKYNLLRLTDLEKEFKEKLKERISEIVNLIPFNITKEEKFREHLLENLTQTMIEALFEGEIEPEILKRLNVSKRDFYETDTFGFLGYPVLQAADILIYKGEGVPVGEDQLPHIELSREIARRFNRLYGKIFPEPKALLTETPKIPGTDGRKMSKSYGNAVFFSDEKEEVEKKVMKMFTDPQKIRKNDPGRPEICPVFSWHKLFTKDEELVKKIEEDCRAGRLGCVECKRILLKHLEEFLEPIRERRRELEKRINEIEEVFYENSRKAREIAQKTMEEVRKAMNLP
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MSEAMGTAGCVPCHGALQVGFYDEQCGANDVESIVRGVVTTSFASDQTIVAALLRLQFHDCFVTGCDASLLLDGNSTEKNASPNRSMRGYEIIDEAKAAVEALCPDLVSCADIIAIATRDAVSLAGGPSYNVQTGRRDGLSAATTVNLPSPSFTVSQSIAAFKTEGFNVNDMVLLLGAHTVGVTHCPLIQSRLYNFHGTGNPDPSMDKTLASQLRTICPNTNPPPGTPVFLDQNTSSAFVVDNDFFKQILSNRGILQIDRALALDPATRNIVTALASDGPSSPGLGLGRGSGRGRGRGRIVSNFMSGFGEAMVKMGALQVLTGSQGEIRKSCRVAN
The following text describes a protein:
Function:
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MERCLPVGDDHHGRDNIPSLQQSVPTSAEDYLMNVRHEANNCPDVVVAENFDSSRFNSRRTVNYTKSSSLLPTPPSEEIQDFLIHTFSENRQPAMKDENGWLTFCLGSNKHRGNPPTLALLASMKYAVLIKAFENLTEGFNQKEFTDLFGQWLYALLVCVEKPLLPETTSMLRILARNCSERRETLATDDHLVSALNLIIVIVARSLEIGDLQYTVAVTAILDAQDSKTSA
The following text describes a protein:
Function:
Required for correct translation termination (By similarity). Positive regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression. Also acts as a direct inhibitor of ofd1. Functions probably by inhibiting the ability of the ofd1 to accelerate Sre1N degradation in absence of oxygen.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MIGRRPQGLRAAASLKKQQQLEKQKQEASYELSGNSSPSKENGSENVDNGEMEDETMLVYTEEDNISQLWGLYEMSREKLENDDIDASVSLVFGTIHEADRILRNTEDISTLPKDFHAAYSSALLAVSELFEIAQKRLKETNTEESYIDAAIERAQLGLDAPGNESRLFLALARAYLEKVRVLVWRHDNEESLANIPVTQLVNPYIEKAIQYLRPLAQDSTEYFDALTPDSLRPLYILSSYLFQFGDQFSEAFLLDVCSIITALWLKSVVDPNTPAYYKLIAQEAVLNNYTTFAEYYMDLLDNSESNVDDLINKASSWLNNSVDTWNVIYTLDKSPERLLKLADIKMDLAQIVQDEASQDNYLKEACNAIKEAQGSGVELSPDYVEFVEAYSA
The following text describes a protein:
Function:
Multifunctional enzyme that catalyzes the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAGSDQISEFCRALGGDTPIRSVLVANNGMAAVKFMRSIRAWASETFGTEKAILLVAMATPEDLRANAEHVRIADQFLEVPGGTNNNNYANVQLIVEIAERTRVSAVWPGWGHASEDPELPDALKEKGIIFLGPPSAAMAALGDKIGSSLIAQAAGVPTLPWSGSHVKVPQETSCHSIPEEIYKKACVSTTEEAVASCQVVGYPAMIKASWGGGGKGIRKVHNDDEVRALFKQVQGEVPGSPIFVMKVASQSRHLEVQLLCDKHGNVAALHSRDCSVQRRHQKIIEEGPITVAPPEKVRELEQAARRLAKCVQYQGAATVEYLYSMETGEYYFLELNPRLQVEHPVTEWIAGVNLPASQVAVGMGIPLYNIPEIRRFYGLEHGGGYHSWKEISAVAAKFDLDKAQSVRPTGHCVAVRVTSEDPDDGFKPTGGRVEELNFKSKPNAWAYFSVKSGGAIHEFSDSQFGHVFAFGESRSLAIANMVLGLKEIQIRGEIRTNVDYTVDLLNAAEYRENKIHTGWLDSRIAMRVRAERPPWYLSVVAGALYEASSRSSSVVTDYVGYLSKGQIPPRHISLVNLTVTLNIEGIKYTVKTVRGGPGSYKLRINESEIEAEMHSLRDGGLLMQLDGNSHVIYAETEGAGTRLLINGRTCLLQKEHDPSKLLADTPCKLLRFLVADGSHVVSDTPYAEVEVMKMCMPLLLPASGVIHFVMPEGQAMQASDLIARLDLDDPSSVRKAEPFHGTFPKLGPSAAISGKVHQKFAASVNSAHMILAGYEHNISHVVQYLLNCLDSPELPFLRWQELMSVLATRLPKDLRNELDGVYKEYELNADFRKGQDFPAKLLREVIEANLAHCSEKDRITSERLIEPLMSLVKSYEGGRESHACVVVKSLFEEYLSVEELFSDDIQSDVIERLRLQHAKDLEKVVYIVFSHQGVKNKNELILQLMDGLVYANPSAYRDQLIRFSALNHTAYSGLALKASQLLEQTKLSELRTSIARSLSELEMFTEEGEQVSTPRRKMAINERMEDLVCAPHAVEDALVALFDHSDPTLQRRVVETYIRRLYQHYLVRGSVRIQWHRSGLIALWEFSEEHIGQSAALLKQQVQDPRGRRWGVMVVIKSLQCLSTAIEAALKETSHYRAGAGSVSNGNPINSNRGNILHIALVGISNQMGTLQDSGDEDQAQERINKLSKILKDTTITSHLNGAGVRVVSCIIQRDEGRPPMRHSFQWSFDKLYYEEDPMLRHVEPPLSTFLELDKVHLEGYSDAKYTPSRDRQWHIYTLVKNNKDPRSNDQRMFLRTIVRQPSMTNGFSFGHIDNEVCRAQASSSFISNSILRSLMAALEEIELHAHNEAVRSAHSHMYMCILREQRLFDLIPVSTRMDEVGQDEETACTLLKHMAMSIHEHVGVRMHRLSVCQWEVKLWLDCDGQASGAWRVVVTIVTGHSCTVDIYREVEDSNTHELFYRSATPAAGPLHGIPLHEPYKPLDALDQKRNTARKNETTYCYDFPLVFEKALKESWKSGISHVAEANGHNQRYAQVTELMFADSTGSWGTPLVPVERPPGMNDIGTVAWNMKLSTPEFPDGREIIVVANDVTFKAGSFGPREDAFFDAVTNLACERKIPLIYLAATSGARLGVAEEIKACFHVGWSDDESPERGFQYIYLMEQDYSRLRSSVIAHELKLESGETRWVVDTIVGKEDGLGCENLHGSGAIASAYSNAYRETFTLTFVTGKAVGIGAYLARIGLRCIQRLDQPIILTGFAPLNKLLGREVYTSQLQLGGPKIMAANGVAHLTVSDDLEGVSAILKWLSYVPAYVGGPLPILTPLDPPERPVTYLPENSCDARAAICGIQDTQGGKWLGGMFDRESFVETLGGWAKTVITGRAKLGGVPVGVIAVETETMMQVTPADPGQLDSAERVVPQAGQVWFPDSAAKTAQALLDFNHEELPLFILANWRGFSGGQRDLFEGILQAGSMIVENLRTYKQPAFVYIPKAGELRGGAWVVVDSKVNPEHIEMYAERSAKGNVLEPKALIEIKFKPNEVEESMLRLDPQLVRLNASLLKEIKIGTSETEAIRIRSMMTARMKQLMPIYTQVATRFAELHDTTSRMVAKGVIRKVVDWEESRAFFYRRLRRRVAEDSLAKQVREAAGEQMMPTYGSALECIKEWYMASQGQGDGEKWDDDEAFFAWKDDCSNYDKHLEEMKAERVSRLLSQLAESSDVKALPNGLSLLLGKMNPSKREQVINGLRQLLG
The following text describes a protein:
Function:
Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKSQEQQTPETREKSSSTSESGHPISLDSKTPPPNDSKIESIVKAQILFLLSTLREDQYDTKLEQIRQLINKNAPRVYHHFLRRLIQGNSYRIFGTGKSSDGLATYKLLLDELKSLTKSWVMAKRFSDAISGSDSEVFEDFDIEAFLDHFQFSPLERTNLLIGLTTSVKPTLAKKASALLKNTFQSLLNQLSDPTQQQSIDKNDLDLLREGLFTTDYDRIPLIKVPKFDAIIEKKLANSRPLTALFGPMKASKATLKSMKEAILKKYPPGTATETDVAYLINSLVAIHDYGAWDTVLMGKAIVSSFENLNWEAMLSMFDNPKFMITGTPSLVLFFTIFTNAYKLRQTNFTLDFLWVLWRNPLPQLSIISHIILSPTSMFDIREFNVNPVVSVDSLKDYSEELVNYAKIYEKSNLNCIELVQILLRLLSEVVTYETSLFLNFLDEKVSAELLLLGTLQLPLAWNPVQESLAFQWCSDFFSNFKEHKFVFVRIERTNPQFLFAFLRSLWLKDSSSVNQVVEFIIENDFTSHIGNIQPNRFALEIAALAAARKALSFQDWLDKKMLEFEDADGLNVFLVEVLDFLMSRAALQKNESEQKEESVVLSIDTVNVLLTTLMDNVSISEEVSEHIKDVQILCLQVYPRLFSLGHDRDSIVIATNTTNSFSPDVESEVESYFQALYERRISIGKIVLTLQNFKKSENPRDLDLFACLQHSLFDEYRFFPDYPLEALALTAVLFGSLIQFELLSFVPLGVALRYVYQALLMPTDSKMFRFGMQALVQFQEKLPKYINYCNLILGIPSLQLVRPDIYDSIREMIASNENTEVEKDKLDSFSALANPASPKAPEYTFVSIHVPPLNVPNAEGEIEESVCDNILFAINNLSQLNFNEKLKDVKDNLTPAYLPWFSHYIVTQRVSREANFLSLYGKFLEELKSSDLYKIVFRDTLQAILDIMNNNAETLSPSEKTNLKNLGSWLGSITLLRNKPITTLQVSFKDLLLEGIDSGRIDRVLPFVCKVLEKASSSVIFKPPNPWLMGILKLLVELYQFADFRLNLKFEIELLLNNLNVKMDNIEPSEMYRNHLVQKADLEKELPEDVLNAEFPDGTDVITQYIVAASSQITVTDAVAQVFGKPKPAIKNITQLIIQQSVLEIISAVVRRSVGIAAITTKSLLQKDFAAESNPSRLLLAARQMAKTLAGNLAMVTCREPLQMLMINNFRTIALQDVENVHAAVAQAIDELVSQNLFVASSVIESVASETAIAEIDAEIEHMIVERVRHRKTTPNLPFVDPAGAANLHLNLPSVLKLSSELTPQQFQLYENFDRLSLSTIMSNNSFTSLNGLRTDSADSTDALNSNLNNTVENEANQTALNYARNLLIIIGQLFQLAAQMPYTSMQEVPADHELHELVNQFLTGVASINHPIADHVFLLCAQECCRILLTDSKSPFILEVFSAILEYICQASTKTAINVSLYWNFSNDLEKLNLPIILSLIRFGILTSGEVDYHVARGVRSEQGSGPVTDFAIELLRTAVGGENPMALPGNFVNSITSLYEISESFSGETKQAYEQLVETMNKSVSPASEILSDLDNKQQLNDQIIIVFVSWVHLLRNSATNDETKAAFVYQLHKQGILSEPELCIQFFRCNLEAVLVAFLEAASVNAPDYFNVDAYASLLVNVVKYTEGSTEGTVSSKSVLFRKIIALIIGVFAELHNSMAEFVHQKTFFRLFSSILSELDDAKDVLESCFVDIYSVILECFLAIQPRSFPAFTFAWLSLISHSYLLPKVLLVNNDKINDLFSEILMSFLKFLDLKDDIDKAQFKLLYNGFLRIILVLLHDFPGFLATHCYQLIPYIPLECVQLRNMVLSAFPSDLHLPDPFAQGLKVGRLPEVTRAPLISNSVSASLEKFASALDLEACFSSSKPAEVAKLLLEVYSSQDTPTKLNEWANYFMLCLIRHATRDSPAKQAPQFQSKSPECVIISTMNRSCDSKCRYFLLTAIANQLRYPSSHTYYASCCFLYLFKSSSNNPQELLIKEQMTTVLLERIICNRPHPWGLLITFTELLKNEDYNFWKHPYIKRNDEICRLFDSLHEHVMAPSSANNVSTEEATELMGQV
The following text describes a protein:
Function:
Probably a connector protein for RcsB/C regulation of biofilm formation, providing additional signal input into the two-component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB.
Sequence:
MKTSDNERIKYEITGQAVLQILRMKINFSLQTLIKQLLVMKSAEEDAFRRDLIDSIIRDFSNSDSGGPNRRTATADNKSMFNGKKINRIH
The following text describes a protein:
Function:
Involved in the catabolism of quinolinic acid (QA).
Sequence:
MLRQSMIDLFDLYFYEDCPYQDESAELLRLEGQGKMRIISRENGTCACAGELAEYYERKGLKTLNYLGDGETFKPGNAIFEAEGDLKLLFRLWRVSQTFLTITCAIATKTASMVSAGRKVNPDLIIATSRKTHPGFRIFEMKAVRAGGGDIHRNSLSDSIQFSQNHLGVVGELGKLRAVKKIEIEPRSREEAFKYAEMADIMLLDHLSPEELQELGPKLKKLNPKLELAVGGIEAKKIPEYAPFVDIIVISAPYYAKPLDFTTKINRI
The following text describes a protein:
Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
Sequence:
MDTNDLILNVIGSLYEIVKSCYGLNAQYQMLVNDENAKNDDISDYGNETQTIKLSKKASEILKCIKVEHVFSNIVKKSVQMLESICHDGTNTLVLLIYSLFRECDIDLKLLYNTIYSTINTKLDDNIINNDNNSIVSNISKLCLESLKSLYIERNDKQLTVLDIMNNRISFQDQIIIYPRLILSNNPSINLNNESILHINSFIIDNNNNNRINKININNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIIFINEILKLKSNFEKEGITKSDNNNKENEKDKTKLIFHSAQERTELLQYEKLILKNKIINNIILIFKSIDEYSKSLIYNLISNNTNYLIFDNVQEQHIKIITRSFGISVINSIDSTIRDGINDDLFLKNFVGKCGEITFYNSDNKVKLCNLKTKSPLLSVEIYGSSNHILRQRVGSYVTGMGIGKCCLEDLFILPSACSPEFSIIQSLLLNSKHQSENNEKNNDSSSSSSSSSSSSSSSSSSTTYIDKEVYQALIRSIETIPITLLSNQSNKPILKILDSFYCNFKDDIDKIIGINLFSKGEDDFFLNPINNGIFETYRSKFQTFRFAIDIVCLLLKIDQIIQPNQLHQNQQQQQQQQQQQQQQQQISMPTINKKEYIEFKPMEISTDAMEREKIENTKKQNEIFYSKQQVEKRERIDKNFKTNPFTQK
The following text describes a protein:
Function:
Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.
Subcellular Localization:
Nucleus. Note=Predominantly nuclear.
Sequence:
MAQKKYLQAKLTQFLREDRIQLWKPPYTDENKKVGLALKDLAKQYSDRLECCENEVEKVIEEIRCKAIERGTGNDNYRTTGIATIEVFLPPRLKKDRKNLLETRLHITGRELRSKIAETFGLQENYIKIVINKKQLQLGKTLEEQGVAHNVKAMVLELKQSEEDARKNFQLEEEEQNEAKLKEKQIQRTKRGLEILAKRAAETVVDPEMTPYLDIANQTGRSIRIPPSERKALMLAMGYHEKGRAFLKRKEYGIALPCLLDADKYFCECCRELLDTVDNYAVLQLDIVWCYFRLEQLECLDDAEKKLNLAQKCFKNCYGENHQRLVHIKGNCGKEKVLFLRLYLLQGIRNYHSGNDVEAYEYLNKARQLFKELYIDPSKVDNLLQLGFTAQEARLGLRACDGNVDHAATHITNRREELAQIRKEEKEKKRRRLENIRFLKGMGYSTHAAQQVLHAASGNLDEALKILLSNPQMWWLNDSNPETDNRQESPSQENIDRLVYMGFDALVAEAALRVFRGNVQLAAQTLAHNGGSLPPELPLSPEDSLSPPATSPSDSAGTSSASTDEDMETEAVNEILEDIPEHEEDYLDSTLEDEEIIIAEYLSYVENRKSATKKN
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSDRLTQLQECINEQAGHFCNSIGILQGSATPCGFDTNKELQADMHCDNYASFIARTAKDIELLIDSIPIEENMNDLNKEELTTANDKRKELSDQLVDAMDDGEELLSHLREKLDQIAQVQINSRPNK