lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro.
Subcellular Localization:
[Isoform BIN1]: Nucleus. Cytoplasm. Endosome. Cell membrane, sarcolemma, T-tubule; [Isoform IIA]: Cytoplasm.
Sequence:
MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKAQPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQFEAPGPFSEQASLLDLDFDPLPPVTSPVKAPTPSGQSIPWDLWEPTESPAGSLPSGEPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPENFTERVP
The following text describes a protein:
Function:
Stabilizing subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MAARVAAVRAAAWLLLGAATGLTRGPAAAFTAARSDAGIRAMCSEIILRQEVLKDGFHRDLLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLRERNITEAVMVSENFDIEAPNYLSKESEVLIYARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQEFPILKCWAHSEVAAPCALENEDICQWNKMKYKSVYKNVILQVPVGLTVHTSLVCSVTLLITILCSTLILVAVFKYGHFSL
The following text describes a protein:
Function:
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MDAFKLLTRATKLKSGAAPSSTQSLTRLPSTGKAANPQLFRSSEADKVLEEASHGKKRKRVAGPEAAELDDDDDAELNFFGSSKARRSSASMAKEQAKEQQEQQEHRDDTSDADDVDEMDEVQCRTVLNAHKIKVTDMRDLEEIQPVRIESEEPKKKKKKTKQQEESTPALTKKEQKKARRVYPQPLVSFKELRTRYKISRRLAENIAEQGFTVPTEVQLGTLPLLLGGFKASGNSKSAESIEPDLLVVAPTGSGKTLSFLIPVINKIVRHHHEQEKERGIFSVIVAPTKELASQIVNEGRKLVHGTGVKITLMKKGMRVVDREDDDDENSHSEDSEEGSDSEQDEPSTTRKKKGKAPITKSDILVTTPLLLVNALSANRTKPMATLPLVRNIVLDEADVLLDELFREQTLDIWRACTHPELRASLWSATMGSNIEDLAKSTIKERKQAYDQTKSYPLLRLVVGLKDSAIPNIEHKLVYAATEQGKLLGLRQLLHPAAASVSDVRLRPPFLIFTQTIPRAIALHSELRYDIPAEAGGSSRIAVLHSDLSDGQRSEIMKNFRKGEIWILVTTDLLARGVDFRGINGVVNYDIPNSAAVYVHRVGRTGRAGREGGIAVTYYTKEDIPYVKSIANIIDVSEKLRGKDGEKSIQKWLLDALPDLSKKDKKELKKHGVKARQSTLKSVKDDKEHRRTRISTKSGYDRRMENKKKALIAASRNRKSKTQSTDPGSDDESWDGLDG
The following text describes a protein:
Function:
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Specific for GTP.
Subcellular Localization:
Cytoplasm. Note=May associate with membranes.
Sequence:
MKTAALFVSKEFEEEAIALVEGANYKVTSIYKLPKSPNVKFYIQYDKLQQIKNDEEISTLIIFEQLKPRHFINIRRELKGKEVLDKILLLLEIFALHAGSKEAKMQIELARLKYELPIIKETYTKSKIGEQQGPLGAGTYGVESTIKFYKRRINKLMKELESIKIFKEKSIESNKRNNIPSIGIVGYTNSGKTSLFNSLTGLTQKVDTKLFTTMSPKRYAIPINNRKIMLVDTVGFIRGIPPQIVDAFFVTLSEAKYSDALILVIDSTFSENLLIETLQSSFEILREIGVSGKPILVTLNKIDKINGDLYKKLDLVEKLSKELYSPIFDVIPISALKRTNLELLRDKIYQLATQLS
The following text describes a protein:
Function:
ETS transcription factor with a prominent role during development of the eye and the nervous system. Required for glial-neuronal cell interactions at the ventral midline which are necessary for the proper elaboration of commissures in the embryonic CNS; [Isoform P2]: Required for normal EGFR-induced photoreceptor development probably as a downstream effector of Ras85D. In larval eye imaginal disks, activated by MAPK phosphorylation following EGFR activation, induces transcription of isoform P1 which in turn activates transcription of target genes essential for photoreceptor development; [Isoform P1]: Required for normal EGFR-induced photoreceptor development. Following transcriptional activation by isoform P2, acts as a constitutive activator of transcription, leading to induction of target genes essential for photoreceptor development. In larval brains, involved in the maintenance of type II neuroblast self-renewal and identity together with brat, btd and pros; prevents intermediate neuronal progenitor (INP) dedifferentiation by regulating the expression of erm probably via Notch signaling; suppresses Ase expression in type II neuroblasts and promotes the generation of intermediate neuronal progenitors.
Subcellular Localization:
Nucleus.
Sequence:
MELAICKTDLSATKFMLPPALPSSAAIGSSSAVASTASHFLDKAAHELFQLNAINGHLFKSPASSHLNSVGSPSILSQLNGIGNSGNHSGQVSTMRLKKNRKVTFLSSLVESKNIFIKEEPIHGCKDLCSLSDISDHEASLEVPTALPPLTPGTNRKVNEVLKASFASWEKEVQKCNITKDPREWTEEHVIYWLNWAKNEFSLVSMNLDPFYKMKGRAMVDLGKEKFLAITPPFTGDILWEHLDILQKDCEKPNEDIVHGNSFESATTASVCGSDHQVANYPNETHANSNNSSINSRLSMDYVTSAGNSDNKNFHRATPHSHNGYNTSNTHDRINNSTPPQQQQSQQPTVNGSGSASSNNNNSMLPPAVQQSNNENNNTSSSNTNNSSNNNNNSGGSNNSNAGSNNNNNNNNNINFMAAAAIFQHHLKEEPGTQNGNIGGYGGGSNSQNDPTDLSSYGLPAHLAAYGGGSGSGPTGGRSSGGGGDESDYHSTISAQDHQSQQSSGGNGSGGASGGSTGNSNGYLDSSSEFYGSYAGRNRFHDGYPPEFTPYDAQSFQSMGPQPTAMDQWGAAHAHQHPAAYMSTLGLDKGLLGGYTTQGGVPCFTGSGPIQLWQFLLELLLDKTCQSFISWTGDGWEFKLTDPDEVARRWGIRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQNLVGHTPEELVAKYDLKIEKKDVD
The following text describes a protein:
Function:
Required for normal development of ethanol tolerance. Relies on two distinct molecular pathways: a cellular stress pathway defined by hang, and a parallel pathway requiring octopamine.
Miscellaneous:
MISCELLANEOUS: Stress, at both the cellular and systemic levels, contributes to drug- and addiction-related behaviors in mammals. Function of hang suggests that this role may be conserved across evolution.
Subcellular Localization:
Nucleus.
Sequence:
MCDAAAATATTTTTAAVAAAVATTTASVALEATATQPGTTTTTVATASAGTTSPEAAIPTAATATSARNSNSERSARQNCCRLCIAPQTECISIINSYAADKEPLSTKIHNCVGIKVTPQDRLSQQICHACISYLNSWQSFKNRCFSSQAKQRQWLDTNKSKLLNYLDLNSAENGGGGFFDQHLHQQQQHHQHLENELEAEKEKATPTAASTAANILDGIHSLKKRKSLTVYPLPAMPIKDEPIDTDDDYQMKSIDESDDMVDPTMFLERSEHEGDVPLTASDYDYTAQHGVNASSVAASLPPNAVANVAAAGDSKVASCRACSLQFSTRANARRHERNLHPNLFQLSTDSPHNTPITKPTPALAAALEMQRAAAAAATAEANRAAGAAGGNISTQKYRQVVMNAFIKCEGGGYDYDNPEQYRPLLTRDKVEFIEQNDEFLEQYQTMTCRCCNKYFSTYKNFMAHVRKKYPQLPRNLCFNCLKMNDSKALFISHLKKRNCINLFRVLNALRGKTTTVVVPIADDVADDGATGSIPVADAGAGVVAMNSPTVTASGEVVTPGGGSERPEKLRAKELLVNKLYECKLCPKGFRTKHEFRTHVYDKHADVQRKDNNSIQCSFCGLDFADPVDRRRHYNNMDCIVRLRCMTCDAKLETHQRFLDHVYQDHLGGVGGGAVSDNASTTGSGMARSNSMEHSPGKRSLLGALGVGSSAEESRSSSAAPPLTSTPKLAGGNQVGGGGSTSASAAAAAQSSANRDASAPKSQYFSRMPQVCPICGQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRISYLREHMINVHGVDKNRHSGGFEYIVNADAVKLADGSTPNVYTGRYDYVMKDLMSITNGGTLDDEEEEPGSVAKKMRLDDSSNNSSLVGVASQQKECPICNAVFSNNIGLSNHMRSHYTASNAVNAALAAANRMTPKSLTITATPATDSELGVGGTMSESAPATPANVPPAMANQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGKAIKDEMIIKQFECDVCSIVYSSESELQQHKRSVHKLTSASASTSASTSSKIDDDSLMDDGKPTSSDLADLSTLAAGGSTASAPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPNPAECSLCRKVFFDRQMHDNHTPTCNRKPITSTGAHQQQDGQLHSHHTAKRTIFRHKTGDDDDEEDDDEQQQLEERANSDGNGTTVGVASGSTAAAGTSLKIRIPEVACTICGARFTDQEHFSKHIQKHEQELYVDNPLAAMFDDGPADAGQFQVERQNENGEYACDLCAKTFPQVIALKVHRKWHFRGDSKQNPIDGEATQLTNNNHTTNNNNNNSMHLRELHAVGLMPNQQQQSLNNSCNSSMNHNNNSSSNRSKSMKRKRELKCEYCASTFISNNNLRRHMYELHKHEVSNLPEPPVIVVDDHLTCRRCQLKFDTKELWIEHKLADAKVVRPFCPFQWGCDLCGEYLSRKEKLMNHINNHLKEEVIVPVATKAAIERTAAMESAAADANAAATLSALGEGAETEDQFAEKVEAAGATTTDKLTNPDEEDSDDLDEDSSGDDDDSSGTGDDDDDDDSDDDEDGEGEDEDEEGDGGEGEDEEGVQPPAQLLPQQQHKTDLNLNQDDDDLVEEVISSDDDEDDDGEVESDDDDEDDDDEEDDVEEPEPVGLTVRPLMNGKSKMPPLIVASSDDEDDGVMPIEDIIEEEFDEDADPDPEDAIEEVDEDDLDEGEVEDEPNVVSTASFSESESSTTTTSNSHSHSHSTGERRKKAVDQLNDPGFTCDLCQLCFDSQELLQSHIKSHILNGPKLSTVSAAAAAAAAAATASSKATALLTAAKAKPDSKSAVLANNNNSKTSSKTVAAGATN
The following text describes a protein:
Function:
Involved in branched RNA metabolism, modulating the turnover of lariat-intron pre-mRNAs by the lariat-debranching enzyme DBR1. Enhances the debranching activity of DBR1 in vitro.
Miscellaneous:
MISCELLANEOUS: Present with 1270 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Relocalizes to the cytoplasm in response to hypoxia.
Sequence:
MTNAKILVAHISESDADEAIRKIKKVNEKSGPFDLIIIFSNSYDENFELNTDGLPQLILLSCDKANNSKSKKINENVTLLHNMGTYKLANGITLSYFIYPDDTLQGEKKSILDEFGKSEDQVDILLTKEWGLSISERCGRLSGSEVVDELAKKLQARYHFAFSDEINFYELEPFQWERERLSRFLNIPKYGSGKKWAYAFNMPIGDNELKDEPEPPNLIANPYNSVVTNSNKRPLETETENSFDGDKQVLANREKNENKKIRTILPSSCHFCFSNPNLEDHMIISIGKLVYLTTAKGPLSVPKGDMDISGHCLIIPIEHIPKLDPSKNAELTQSILAYEASLVKMNYIKFDMCTIVFEIQSERSIHFHKQVIPVPKYLVLKFCSALDRQVHFNNEKFTRNAKLEFQCYDSHSSKQYVDVINNQSNNYLQFTVYETPEADPKIYLATFNASETIDLQFGRRVLAFLLNLPRRVKWNSSTCLQTKQQETIEAEKFQKAYRTYDISLTEN
The following text describes a protein:
Function:
Suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects. Required for proper cytokinesis during vegetative growth, timely exit from the mound stage during development, and myosin II assembly. May be a regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) and may control localization of PP4 to the nucleus. Involved in the regulation of some ppp4c functions, such as developmental progression, chemotaxis, expression of stress response genes and cell movement.
Subcellular Localization:
Cytoplasm, cell cortex. Nucleus. Note=Localizes to the cell cortex in vegetative cells but translocates to the nucleus during starvation and development.
Domain:
The EVH1/WH1 domain is necessary for cortical localization.
Sequence:
MEPLRKRVKVYQLDNSGKWDDKGTGHVSCIYVDALCAMGLIVRSESDNSVILQTRLSAEDIYQKQQDSLIVWTEPDSQLDLALSFQDSLGCQDIWENILQYQNQRTGSCDSVDLDLPPVSINNLQTINELLEASLPMLDKDKIINSIFKEDLVRSLLDLFDEIEKSGEGGVHLFQIFNIFKNLILFNDTSILEVILSEDYLVRVMGALEYDPEISENNRIKHREFLNQQVVFKQVIKFPSKSLIGTIHQTFRIQYLKDVVLPRVLDDVTFSSLNSLIYFNNIDIVSQIQNDSDFLENLFSEIQKSEKNSEERKDLILFLQDLCNLAKGLQIQSKSTFFTVVVSLGLFKTLSAILDDENVQTRVSCTEIVLSTLLHDPEILRSYLCSPTSGNSKFLVQLINLFITDKDIGVKNQIVEIIKTLLEADSYDSSDFFRLFYDKGIDLLVSPLNEVYKGEPTIPGDPSSNLDSFVLYNIMELVIYCIKHHCYRIKHFIVEEGIAKKILRYTNPTGSGGGGGGGGNSERYLILGSIRFFRSMVNMKDDLYNQHIIQENLFEPIIEVFKSNISRYNLLNSAIIELFQYIYKENIRDLIVYLVERYRELFESVTYTDVLKQLILKYEQIKDSSFESPETSCNNNDSSSNDIDSKPIIGNNKINHNYQRTQREIDEEEEEAYFNRDDDSEDSDDEDELIPISINNNNNNNNNNKQICTNNENNMEKNDDNIEKDNENTNNGNGSSHIKIVDYEDEDDEDDEINKSVESDDIVEKHEIIDKNEKKDEIMKENNDSDNDDNDNNDNDNDNDNNSDIENKNHLNNNGNNENNENNDDVQDKSNNKNNSDKINEDEKIEKQDEMKENLEMEEIDEKVKEKQPKDIKKENQSQPDETVFNGKSNNSNNNNNNNNNNSNNQEIGDNRKTTPKRKLDYEKNESVVSKKIDKSNGPTSIDKDINGCDESPNKKLNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNQNDENELSSASEEEEEQLENGKHIKKFKRGKKDSNNSSNNSNNSSPTPSELHV
The following text describes a protein:
Function:
Probable transcriptional activator that promotes chloroplast development. Acts as an activator of nuclear photosynthetic genes involved in chlorophyll biosynthesis, light harvesting, and electron transport (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MLEVSTLRSPKADQRAGVGGHHVVGFVPAPPSPADVADEVDAFIVDDSCLLEYIDFSCCDVPFFHADDGDILPDLEVDPTELLAEFASSPDDEPPPTTSAPGPGEPAAAAGAKEDVKEDGAAAAAAAAAADYDGSPPPPRGKKKKDDEERSSSLPEEKDAKNGGGDEVLSAVTTEDSSAGAAKSCSPSAEGHSKRKPSSSSSSAAAGKNSHGKRKVKVDWTPELHRRFVQAVEQLGIDKAVPSRILELMGIECLTRHNIASHLQKYRSHRKHLMAREAEAASWTQKRQMYTAAAAAAAVAAGGGPRKDAAAATAAVAPWVMPTIGFPPPHAAAMVPPPPHPPPFCRPPLHVWGHPTAGVEPTTAAAPPPPSPHAQPPLLPVWPRHLAPPPPPLPAAWAHGHQPAPVDPAAYWQQQYNAARKWGPQAVTPGTPCMPPPLPPAAMLQRFPVPPVPGMVPHPMYRPIPPPSPPQGNKLAALQLQLDAHPSKESIDAAIGDVLVKPWLPLPLGLKPPSLDSVMSELHKQGIPKVPPAASGAAG
The following text describes a protein:
Function:
Involved in the import/insertion pathway in the thylakoids. The signal recognition particle is not involved in the insertion of SECE1 in the thylakoid membrane.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MSLTAQFSPPVTGITRSLRDTKPSLSNLRVFPVYTEIRTMTTSNLRKSACFVAKAIEQRRDTAGSESESEATPSPAEESGSGEDKEVEISAIGAEIKAAMEQRKTAEEEKGKNEFLSGVAEEVKEIEWPAFQKVLGTTGVVLGVIAGSSVVLLTVNFLLAELSDRVFIGRGVQDFFS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors (By similarity).
Subcellular Localization:
Photoreceptor inner segment. Cytoplasm, cytosol. Note=Colocalizes with RD3 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer; [Isoform 2]: Mitochondrion.
Sequence:
MAGPRPVVLSGPSGAGKSTLLKKLFQEHSSIFGFSVSHTTRNPRPGEEDGKDYYFVTREMMQRDIAAGDFIEHAEFSGNLYGTSKEAVRAVQAMNRICVLDVDLQGVRSIKKTDLCPIYIFVQPPSLDVLEQRLRLRNTETEESLAKRLAAARTDMESSKEPGLFDLVIINDDLDKAYATLKQALSEEIKKAQGTGHA
The following text describes a protein:
Function:
RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs. Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome. Also binds the poly(A) tail of mRNAs; controlling poly(A) length.
Subcellular Localization:
Nucleus speckle.
Sequence:
MEIGTEISKKIRTAIKGKLQEFGAYVDEELPDYIMVMVANKKNPQQMADDLSLFLGNNTIKFTVWLHGVLEKLRSVAVEPPSLGPSVVHSETSIPAENSRRGAEPRALAVSSSRSDKAEGRVSSSAHENRASKRGSSERPSRLTSAVKPLMEASAEAVIDIKPDLDDDLISYDPVEHSLTSGHSQALYSRSTAERQRPAVESSRRTADTYRSSDISRGQDRSERGYRSSAESSRDLSRKRKAPVASSVVRVHRGHERGLEIEDLEEEEEDEDYGLASKVSLPSKPERKPTLPPAKQANKNLILKAISEAQESINKTTSQYTVPQRQTVPVAPRTRSASDEMSNAAIRLVQEHLHALTPQDTLHNTQSRGLASRLQLEVPEEDSREPHEYELQVLEAARLKALDTRSFIMRQPEVEQPPPIRSRLSAVNQNENAPTTSRMVQARERAEAVGGSSPKFIVTLDGVPSPLANRTDQEMETEDELNTTADLPENNNNNNTTTTTSKPAVHLRLGADLRNACDDEVEEMDIEAVQAKRQKLPERCKFWPTCKSGDECLYHHPNTQCKVFPNCKFADKCLFIHPNCKFDAKCTKADCPFTHVSRRLNSNPTRAAPALTSTVCRFFPECKKVDCPFYHPKPCRFATQCKRADCTFYHPAVAVPPRSALKWTKTQSS
The following text describes a protein:
Function:
Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (By similarity). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).
Subcellular Localization:
Secreted. Note=Secreted from pancreatic acinar cells in its inactive form.
Sequence:
ENGISPRAVWQFRSMIQCTIPNSKPYLEFNDYGCYCGLGGSGTPVDELDACCQVHDNCYTQAKELSSCRFLVDNPYTESYKFSCSGTEVTCSDKNNACEAFICNCDRNAAICFSKAPYNPENKNLDSKRKCA
The following text describes a protein:
Function:
Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins (By similarity).
Subcellular Localization:
Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Domain:
The FF ER export motif at the C-terminus is not sufficient to support endoplasmic reticulum exit, and needs assistance of Gln-508 for proper recognition of COPII coat components.
Sequence:
MAVSRRRVPQAGARSFFCALLLSFSQFTGSDGTGGDAAAPGAAGTQAELPHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSADQIRIAPSLKSQRGSVWTKAKAAFENWEVEVTFRVTGRGRIGADGLAIWYTENQGLDGPVFGSADTWNGVGIFFDSFDNDGKKNNPAIVVIGNNGQINYDHQNDGATQALASCQRDFRNKPYPVRAKITYYQKTLTVMINNGFTPDKNDYEFCAKVENMVIPTQGHFGISAATGGLADDHDVLSFLTFQLTEPGKEPPTAEKDISEKEKEKYQEEFEHFQQELDKKKEEFQKGHPDLQGQPADDIFESIGDRELRQVFEGQNRIHLEIKQLNRQLDMILDEQRRYVSSLTEEISRRGAGTPGQPGQVSQQELDTVVKSQQEILRQVNEVKNSMSETVRLVSGIQHPGSAGVYETTQHFMDIKEHLHVVKRDIDSLAQRSMPSNEKPKCPDLPPFPSCLSTIHFVIFVVVQTVLFVGYIMYRTQQEAAAKKFF
The following text describes a protein:
Function:
Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (By similarity). Contributes primarily to nonhistaminergic itch sensation (By similarity). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (By similarity). Contributes to the regulation of food intake (By similarity). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity); [Neuromedin-C]: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation.
Subcellular Localization:
Secreted. Cytoplasmic vesicle, secretory vesicle lumen. Cell projection, neuron projection. Note=In neurons of the retrotrapezoid nucleus/parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex.
Sequence:
MRGREFPLVLLALVLCQAPRGPAAPVSVGGGTVLAKMYPRGNHWAVGHLMGKKSTGESPYAYEGGNMKEQLREYIRWEDATRNLLSLLEAKGIGSHQPPQWEPLGIRQSTWDSKDGSNFKDMGPRLKVDGLSAPGSQHEGRIPQLN
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity; Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells.
Subcellular Localization:
Nucleus.
Sequence:
MSAANSPGGSRGAGADPMEEDAPQQQQQPANSARTASGLGNADAPGSQQGTPAAHQQQAQPQPSGSVQQQGASDATAGAQHGAATPLPRGHNRGELGGGAMARPNVRVGTAAKPQRTASVSTVLPGALNEDDRELPPAVDAAVDDGTYVWGTNINSRQLRSQIEAFIRQYRPAGAAAGSVPKYVQIIKEAIEAGETSVNVDTADMRAVDPETGTAPHASLYETLVDFPREVHCVLDEVVREVAVKDLDFEPELLDRQQAMDLCMLVCRPYNLAAVKHIRDLDPSDIDKLVCIKGMVTRTSAIIPNLRYAVFECAACGQEVAAPNVGGRVEDPTGCAGCKKKWSMALQHNKGQYTDKQLVKMQESPNDIPEGETPMGVTLYSYDTLVDVARPGDRVTITGIYRAAAVRANPRQAALYAMFRTYVDVVHVHRDESRRLFSAAGGAADAAAAEAEPTVLSCPNTPADSQSGEPPVTETQADPAAASDEQFVAIENITAEELREVEGQIKELAADPRLTQRLIASLAPNIWEMDDIKKGVLCQLFGGCSKAFPGGKIRGELNVLLVGDPSVSKSQLLTYVHKLAPRGIYTSGKGSSAVGLTAYVTKDPETKEMVLESGALVLSDRGVCCIDEFDKMSDSARSMLHEAMEQQTVSVAKAGLISTLNARCSVLACANPIGSRYNPNMSIAENINLPPTLLTRFDLIYLVLDRYEEQRDRRLARHLVSLFHPGSTDRSRTAGAGDLISPDLLKKYVAYARARCQPKLSDEAAEELVTRYQTLRRDGRERKVVMATPRQLESLIRIAESLARMRLDAHVRRDDVAEAVRLWYGAMAGSTSGGAGGGDGRPDLDTLYTGTTAAQREAARALPEELRAFFQNTRLHHALSLDDLLRDLNHQLQQQAQQQQQQQGGAAAPRKAAAGGVSRAALINALRQLDDLVVFDQLTNTVRSVNRPAQQAPAQGGAAAAKEAEAAAAQAAAVLAAAVLAA
The following text describes a protein:
Function:
Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MEVAGYGTHNRDLKQWMVTLLSALSLMMVVVTIGLLALFLVFDIQVNSNSGQKSSNQLKDLQETNENLVDEIFIDSALNNRYIKNHVVGLTPEEDDTKADIVMVFQPPATGRRTVGKKTHHSILDQKTRNARALPADVSLVQVKDCGKRAIPLIANRIVSGNPAAKGAWPWQVSLQRSNIHQCGGTLIGNMWVVTAAHCFRTNSNPRQWTLSFGTTINPPLMKRDVRRIIMHERYRPPARDHDIALVQFSPRVTFSDEVRRICLPEPSASFPPNSTVYITGFGALYYGGESQNELREARVQIISNDICKKRHVYGNEIKRGMFCAGFLEGNYDACRGDSGGPLVIRDNKDTWYLIGIVSWGDNCGQKNKPGVYTQVTYYRHWIASKTGL
The following text describes a protein:
Function:
May play a role in embryogenesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MSISKAAFLNHLQTLSRSYRHRVLPQPFLAVRYMSFATQEEAAAERRRRKRRLRMEPPVNSFNRSQQQQSQIPRPIQNPNIPKLPESVSALVGKRLDLHNHILKLIRENDLEEAALYTRHSVYSNCRPTIFTVNTVLAAQLRQAKYGALLQLHGFINQAGIAPNIITYNLIFQAYLDVRKPEIALEHYKLFIDNAPLNPSIATFRILVKGLVSNDNLEKAMEIKEDMAVKGFVVDPVVYSYLMMGCVKNSDADGVLKLYQELKEKLGGFVDDGVVYGQLMKGYFMKEMEKEAMECYEEAVGENSKVRMSAMAYNYVLEALSENGKFDEALKLFDAVKKEHNPPRHLAVNLGTFNVMVNGYCAGGKFEEAMEVFRQMGDFKCSPDTLSFNNLMNQLCDNELLAEAEKLYGEMEEKNVKPDEYTYGLLMDTCFKEGKIDEGAAYYKTMVESNLRPNLAVYNRLQDQLIKAGKLDDAKSFFDMMVSKLKMDDEAYKFIMRALSEAGRLDEMLKIVDEMLDDDTVRVSEELQEFVKEELRKGGREGDLEKLMEEKERLKAEAKAKELADAEEKKKAQSINIAALIPPKAVEEKKETAKLLWENEAGGVEEADVVEMAKGVEAGGSNGQDPPSC
The following text describes a protein:
Function:
Serine/threonine-protein kinase.
Sequence:
MSKRKSPHDFLFREELGHGSYSTVYRVVERSSQHQYAIKICSKRHIIGENKVKYVTIEKNTLNLLGQANHPGIIKLYYTFHDQENLYFVMDLAPGGELLQLLRRQRVFSEAWARHYMCQLVDTVEYIHSMGVIHRDLKPENVLLDKEGRLMIADFGAAYTVGQSDAGSDGDKPATSFVGTAEYVSPELLLENKSYYSSDVWALGCMLYQFLQGTPPFRGQNEMETFEQIVNLDYTWRIPANPLAAGLVSKILVLDPSQRYTLEQIKKHKWFSGVDWNNKEKIWRGSWTIASESTPRPRVGYKSRELLDTPIKNIPVVTQRNKKPTKMNTTSSIVEWRKMLGLSGNDLGIKATLGGNGLPIAPFTPTSGITPDNRGDNAVAPAKTRDAFRPMSSRVISSPHSKPSGRPAALPLPLQTGTPSHNVVQQIVVNTPGRTETSSPYVSPTVPVRNAIWKQDWVQLHEIPYSAKYSGLTLAGFSQVSDTLIADLISHHANELRTLSRTGILSLDNTGYLSFIEQGRARPLSRIIDPDLSIYEYQLGHSTEDDFLILEKYKQSIWIVWPNKPTSASRRIPIKETWAQTLSKYKKQVSDEEELSAKLNRTCVSSWGSRTPSPTYPAEGKTRVAVQPQDIPLPSPAKSSSNSGVSEPISKIPPRQLVSASEQSHKAKSEAHTKKANSYSYIAPNDMVLSSSRYEVLRTASNNDSKSNGAAVSGASAAFRTLRVNK
The following text describes a protein:
Function:
Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MANSALETTISKILEQTEKSVISNVESALNESLKTLDDSVPKLEQEFDKIIADGKKEADKIEKQIMGSADIEARNKQLMALEDAVDKVFSKALEQIANADRSGDYSNLIKTMITEATQILGTSEITVTTNAKDKDVVQSTLSQFPGSELSSDTIDCLGGVVVKSKDGAMTFDNTIDARIERLKPLIRKEIASKFGVGE