lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2.
Miscellaneous:
MISCELLANEOUS: Depletion of WDR36 mRNA in cultured cells causes apoptotic cell death and consistently associates with a reduced 21S rRNA and delay of 18S rRNA maturation.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The WD repeats are grouped into two tandem seven-bladed beta-propeller regions.
Sequence:
MERASERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYDVQKLSLVAVSNSVPQDICCMAADGRLVFAAYGNVFSAFARNKEIVHTFKGHKAEIHFLQPFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQSFSTVHEKFNKSLGHGLINKKRVKRKGLQNTMSVRLPPITKFAAEEARESDWDGIIACHQGKLSCSTWNYQKSTIGAYFLKPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLNVSMSPTGDFLATSHVDHLGIYLWSNISLYSVVSLRPLPADYVPSIVMLPGTCQTQDVEVSEETVEPSDELIEYDSPEQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPGLVPRYAAPEQNNDPQQSKVVNLGVLAQKSDFCLKLEEGLVNNKYDTALNLLKESGPSGIETELRSLSPDCGGSIEVMQSFLKMIGMMLDRKRDFELAQAYLALFLKLHLKMLPSEPVLLEEITNLSSQVEENWTHLQSLFNQSMCILNYLKSALL
The following text describes a protein:
Function:
Part of the nuclear pore complex. Serves as a docking site in the receptor-mediated import of substrates across the nuclear pore complex including emb, RanGAP and phosphorylated Mad. Protects mbo/Nup88 from proteasomal degradation at the nuclear pore. Together with mbo/Nup88, sequesters emb in the cytoplasm and thereby attenuates nuclear export signal (NES)-mediated nuclear export. Together with mbo/Nup88, required for the nuclear import of the Rel family transcription factors dorsal (dl) and Dorsal-related immunity factor (Dif) and the activation of an immune response.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localization to the nucleus membrane depends on mbo/Nup88.
Domain:
Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG-rich region is required for emb localization to the nuclear pore complex.
Sequence:
MAQNAPDCEDTQDFQFKLHHKIVAFKKCGEPRSNVNLLAVSSSRGLLFAGSPTQPELKVIIVKDLVNAKSTAQQPQARLVPLPSIPNYIACSSDGNLLAVNHTQNGTSLLSIYAVLSFMTPDVRPVYNIRLAAEDHVHGVQLLWNPVLPNSLAVVLSNGALAMYALKEGGNFEMHSLDKNQQVKCGCWSPKGKQIVLGFPGGTVKQFKPDLTLAKTLLCPPNIHDAPFDTIAIQWLSTFQFAVIFLQHGEDCSPSLYILNAPKAGAPSYINYYDICYSMNGPRNHQFVFSHVPQWNLLLVVSANGVEVGIMRSTEAGDTPAWQQLTLLDEARIEMPLSEDKDETFPLGFAFDTSTTHQLTINEKKLQTMPMVHVLSSDGELLSFNFLNVLPTAVSVCSPPPPVADTSGQFKPLNMLLASEEEEQPAWAASPSKAPAATPAASSDISFAFTPNTVTSTPAPSKDKQPSLFSGFGAAAAKAPAPQLSFGTAPTSSPVSFGAPTTNAAKPTTPFGGFGTQATTTAMGSMFSASGANAFGGMALNKPAIASVTPRTAAPGSTVPATPASAPANKPLYTVPLTFTPVDTKPATSAPPQIADESLKPDDTEPIIKDMIALQIEAFSKDIQKQKEQTKELLKGIAAPSALRAYAKRLDDLQELNEQAKDVEFELDVQGLRQGLNEAYAIVAECRGKLEIYRKPEITRLMNSSSCDPSGRRMLARLQSYVAANEAQLRLAQQHVDLQWEQFQDVVRRNSKSRMHMPCLEGIYQRLTRLQNLTSNQRIVQNNIKSKLKERGLLQAALLDQEKSRTRTNEAVDTLTDSILTMSLSQVVDSNAAKLTRERLQKIRNIVQLQKINVICPQRPDRVGLKSEVILETKRRAEQIKRAAAKPATANKYTQAAVAPPSPPDVAPTPAVAPMPQATVTVAPPLPKPMPSIPSVVEKPGVPTHPTTPVATPFSFSQSIPFVKTSTVTPTTNTVTPGEAAKPGLSIFGGSTISSFSFGGGAAKSALSFGTGSPAVAAPTPKPNPLSAVEKPTPEPTKPKEQKAAESKEFKAVQPETEESKVPQKPKAETENKSFGFGGFTGTGGTVGNTSSSPFSFGGLGSSLGFGGTAAAVPKSEPSSTATTSVATSASTAPFGIFSAALAKPSNSEPITTVTSNTTTITSKPTNVIASSSVTDAPSVTTTNAVTSSTDPIGGLFSSVTICKPNTPADTTKPANIFGGGLSAGSFSFGGTIDASKGLFGSTKPVATAPTSVTEANNKTDPISTTPSAISTTTATTTVSSPAVVPAAVTAAVPATSSTTVTSSTAVPGSAFSFSNAFSTLSAGGAAAPTTSASAPLAAKSPTATSTGNNSSNSVFGGGFAVATSTAAPVASPFQSAAKSPVSSANIFGSIPKAETSVFGGATTAPSNTTAAATPDAPPAGLFASAAISNPSPFGSPTTRAPASGGNIFGQAVKPSVFGQPAQAGDSGGSIFGGGSASTPFGSSSIFGGGNTQGAVGAPAAGSTSIFGQKVFGQSSAAAPAAGGNIFSNPVGSPQASPFGGGGNSIFGSPATAPPASGGSIFGGGSSSGGFGSFTQTTPAQGGFGGGFGQGGGGSVAQTGFGSPQAPQQQTTTPGGFGAKPVFGGSPAFGASPTFGGGATFGSPKGFGGFGGASPVASPPPFGAAAKPAQGNIFETLGGQESGLSFGNLAQTGNSNAQKPAFGGSSFMNYR
The following text describes a protein:
Function:
Able to directly activate the TNF-NFkappaB signaling pathway.
Sequence:
MVVFVGRRLPALLGLFKKKGSAKAENDKHLSVGPGQGPGSAVDEHQDNVFFPSGRPPHLEELHTQAQEGLRSLQHQEKQKLNKGGWDHGDTQSIQSSRTGPDEDNISFCSQTTSYVAESSTAEDALSIRSEMIQRKGSTFRPHDSFPKSGKSGRRRRERRSTVLGLPQHVQKELGLRNEREAPGTPRAPGARDAVRIPTVDGRPRGTSGMGARVSLQALEAEAEAGAETEAMLQRHIDRVYRDDTFVGRSTGTRAPPLTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTKRELAENGGVLQLVGPEEKMGLPGSDSQKELA
The following text describes a protein:
Function:
May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification (By similarity).
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKTVLLFLVALAAAAGPAQALRCHVCTSSSNCKKPQVCSASSSFCKTVIRVEPLSGNLVEKNCSVWCTPTNNQQGQVSKGQETTLCCNSDLCNEALQSWQSAAPARTSAHLGLALACGLLALLWAPGL
The following text describes a protein:
Function:
Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
Subcellular Localization:
Endomembrane system; Single-pass type II membrane protein.
Sequence:
MVVLQMMKHAWNGYVTYAWGSNELRPISHTGHSASIFGRGSMGATVVDALSTLKLMGMNEEFERGRKWVAQNLNFNQASDISVFEMTIRFLGGLLSAYALSGEEVFKVKAKELGDKLLPAFNTPTGIPWAMVNLASGSGHNWGWASGGCSILAEFGTLHLEFVYLSHITGNQVYAKKVHRVREVVDQVQKPNGLYPNYLNPRTGVWGSQHVSLGALGDSFYEYLLKSWIMSGKMDKKARDMYDKAVEAIERMLVQRSRKSNLTYLAEYKYGRLEHKMDHLACFTAGMFALGAKESKNEKHYLQLGAELANTCHEAYKRTATGIGPESFRFEGNAEAVAIRNNERYYILRPEVIEGWFYMWRFTRDSKYRDWAWEAAQNIEKHCRVDGGYSGIRDVTNPNVAHDDVQQSFFLAETLKYLYMIFSDDSLLPLDKWVINTEAHPLPVIGKAELPGGVHS
The following text describes a protein:
Function:
Acts as a radical domain for damaged PFL and possibly other radical proteins.
Sequence:
MITGIQITKAANDDLLNSFWLLDSEKGEARCIVAKAGYAEDEVVAVSKLGDIEYREVPVEVKPEVRVEGGQHLNVNVLRRETLEDAVKHPEKYPQLTIRVSGYAVRFNSLTPEQQRDVIARTFTESL
The following text describes a protein:
Function:
Involved in amino acid permease processing and required for the efficient translocation of structurally related amino acid permeases from the endoplasmic reticulum to the plasma membrane. SHR3 may function as a permease-specific 'adaptor' molecule that functions in conjunction with the SEC62/SEC63 complex. Yeast cells may require SHR3 to expedite the processing of permeases to ensure their rapid expression at the plasma membrane in response to changing environmental conditions.
Miscellaneous:
MISCELLANEOUS: Present with 6510 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MFSYSDFCSIGTAMILSATTFLMGVFFSNMPYDYHLLFNPNSTQEHFDLALRHYQILHETPLPVIVTLCVVAGIGLVGGTIKVFKPNPELQMFEYCSLGLYVLAICVFLTNVKTGIDCSVSHNWGEVTENQGLAVIASSNIILLVMFAGVIILQIGLWYSNWDLQKRLKEFYAQEEREAANAGKKTEKVDNAKKNDNKSKGAQKRKNAKK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Sequence:
MRGQQQSCAAQEQAHQDSMRGELQIDMESEIVQQETDMAAQEPTESRFTQTEQRGMVVQKKRLQTIWKRPAVMEHRNTSVHKTVQNLLEKMTPDDDIETFLAMFERVAEHAKLPHDEWAEVIAPYLSGKSLKAYLGLSKQDTKDYTKLKEEILSCEGITLAGHAQCVQDWSYSPERSVRSQMYDLVSLANKWLQPEILTPSQIVERVVLDKFIRSLPSSIQIWIGKRGPRDVDQLVSLVEWYNATVDHLHGSPMPPLMGCTIPGGLGYPGAEPDCFPIKMEKEEPFSEDVPPTTENALAAGGFPKEDPSVLQVKVETEEPDVEEQLNPMGSSEIAFTAGESCLEHKASWDSGLLRFDLGNQNLQVPEAKAPTHAPEPPQASSDPAEFSRQKEKTKPEINASPRNGQRSMRWKMTHFPCSKCGMTFSTRTDLIKHLCVGKNDVSQHSSELGDPLGAKGERSGHKDGKPYKCHECGMDFADEASLQSHQILHAEDRPFQCNQCGRKFSLRSSLSNHERNQSCEQPFRCKECGKIFSRKSSLHSHQKIHTGERPFICMECGKSFYENSDLRKHKKSHTGEKPFSCPECGRKFSLVCNLHKHRKLHERDHVPHMDSVFLDGMIF
The following text describes a protein:
Function:
Disrupts cell membranes through the formation of pores (Probable). Has antibacterial activity against Gram-positive bacteria S.aureus (MIC=10 uM) and B.subtilis (MIC=0.5 uM) as well as Gram-negative bacteria P.fluorescens (MIC=1 uM) and E.coli (MIC=0.5 uM). Has hemolytic activity against human erythrocytes (EC(50)=7 uM).
Subcellular Localization:
Secreted. Target cell membrane. Note=Probably forms a transmembrane alpha-helix in the target cell membrane.
Sequence:
MKISQVFIFVFLLMISVAWANEAYEEESNYLSERFDADVEEITPEFRGIRCPKSWKCKAFKQRVLKRLLAMLRQHAF
The following text describes a protein:
Function:
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.
Subcellular Localization:
Cell membrane.
Sequence:
MAVEDEGLRVFQSVKIKIGEAKNLPSYPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDFYCEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQLQHVDADSEVQGKVHLELRLSEVITDTGVVCHKLATRIVECQGLPIVNGQCDPYATVTLAGPFRSEAKKTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLKSADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFKESYMATFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKNMFQVIQPERALYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPGCSPCTGGLPANIQLDIDGDRETERIYSLFNLYMSKLEKMQEACGSKSVYDGPEQEEYSTFVIDDPQETYKTLKQVIAGVGALEQEHAQYKRDKFKKTKYGSQEHPIGDKSFQNYIRQQSETSTHSI
The following text describes a protein:
Function:
Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and the reverse reaction, i.e. the reduction of F420 with NADPH. Probably functions in the regeneration of NADPH required in biosynthetic reactions.
Sequence:
MKIAVLGGTGDQGLGLALRLALAGEEVIIGSRDAEKAVSAAQKVLEIAERDDLKVKGATNAEAAEEAEVAILTVPLQAQMATLGSVKEAIKGKVLIDATVPIDSCLGGSAVRYIDLWDGSAAERAARFLEDQGTRVAAAFNNISASALLDITGPVDCDCLIASDHRDALDLASELAEKIDGVRAIDCGGLENARVIEKITPLLINLNIKNRIRNAGIRITNLPE
The following text describes a protein:
Function:
Involved in cell wall peptidoglycan recycling. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha-amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety.
Subcellular Localization:
Cytoplasm.
Sequence:
MRKIKDIEKGLLTDCRQIQSPHFDKRPNPQDISLLVIHYISLPPEQFGGGYVDDFFQGKLDPKIHPYFAEIYQMRVSAHCLIERNGRITQYVNFNDRAWHAGVSNFQGREKCNDFAIGIELEGSNEQPFTDAQYFSLQELTNVIMKSYPKITKDRIVGHCDISPKRKIDPGQYFDWERYLSSVK
The following text describes a protein:
Function:
May function as a periplasmic zinc chaperone or mediate direct transport of zinc from the periplasm to the cytoplasm under zinc-limited conditions. Binds zinc with high affinity, and can also bind cadmium, mercury or nickel. Preferentially binds Zn(2+) over Cd(2+). Contains one high affinity metal binding site, and can bind additional metal ions at other sites.
Subcellular Localization:
Cytoplasm. Periplasm. Note=Cytoplasmic in nonstressed cells, and exported to the periplasm upon exposure to cadmium.
Sequence:
MAIRLYKLAVALGVFIVSAPAFSHGHHSHGKPLTEVEQKAANGVFDDANVQNRTLSDWDGVWQSVYPLLQSGKLDPVFQKKADADKTKTFAEIKDYYHKGYATDIEMIGIEDGIVEFHRNNETTSCKYDYDGYKILTYKSGKKGVRYLFECKDPESKAPKYIQFSDHIIAPRKSSHFHIFMGNDSQQSLLNEMENWPTYYPYQLSSEEVVEEMMSH
The following text describes a protein:
Function:
Modulates the RNA-binding activity of ACO1. May be involved in the cytoplasmic iron-sulfur protein biogenesis. May contribute to oxidative stress resistance and overall cell survival.
Subcellular Localization:
Mitochondrion.
Sequence:
MFGNRIIVSVGNMSALSRVPGTMMRHVLRRCCQVRRVYRLPLTVKHYPVLQQCATFRTICNVRMCSDQQSNSQIALNEYHRIADDTLDGLAEYLEDLGDQDCCPPDYDVQFSSDVLTLRLGGDLGTYVINKQTPNRQIWLSSPTSGPKRYDYSPDRGSWVYRHDNNTMHSLLQEELAAALQLDIKLKHLPYSGGSHSS
The following text describes a protein:
Function:
Transcription factor. Involved in stem elongation, probably by regulating a subset of genes involved in this process.
Subcellular Localization:
Nucleus.
Sequence:
MPLDKRQRDLPLGLSPQACFKDIVGRSVLPRIPLPELGKLYAAKLQARCLQPPPFQSLLCSHDKESYGKRFSRSDMRSWCAAATTTTTPLGALESSQKRLLIFDQSGDQTRLLQCPFPLRFPSHAAAEPVKLSELQGIEKAFKEDGEEFHKSDGTESEMHEDTEEINALLYSDDDYDDDCESDDEVMSTGHSPYPNEGVCNKRELEEIDGPCKRQKLLDKVNNISDLSSLVGTESSTQLNGSSFLKDKKLPESKTISTKEDTGSGLSNEQSKKDKIRTALKILESVVPGAKGNEALLLLDEAIDYLKLLKRDLISTEVKNQSSTTHKSPILLLKETTWGTRNLQTDKA
The following text describes a protein:
Function:
DNA- and RNA binding protein, involved in several nuclear processes (By similarity). Binds the conventional octamer sequence in double-stranded DNA (By similarity). Also binds single-stranded DNA and RNA at a site independent of the duplex site (By similarity). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (By similarity). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (By similarity). Together with PSPC1, required for the formation of nuclear paraspeckles (By similarity). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (By similarity). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (By similarity). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (By similarity). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (By similarity). NONO is involved in transcriptional regulation (By similarity). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity).
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Nucleus speckle. Chromosome. Mitochondrion. Note=Continuously travels in and out of the nucleus. Localizes to stress granules in response to oxidative stress. A small subset localizes in mitochondria.
Domain:
The RRM domains can bind to both DNA and RNA.
Sequence:
MSEYIRVTEDESDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MALYPLPSSIILNKLSFHPFTSRFFPKPLFYCRFSTTSFSTVPQHLIYGPSLYKGHKIAHQNSDNFTRIFDITALRVPSKLCFSLESKLRGHLLNWPRIRNIVRVPGDDIEDELKDFIGDDNRDDDDETLKLLERRIYGRGEGDGEKMCEVLYRDKLARTFNSTGYVKFENLAKISRPKKNKWKREGNGRERRGNGRSDMSMVEVVEEEGSGDDEDFSGLLGDDFSGRKWSGSTRLLLLDERYANKGIEEMPEAIKAVLKEHNEEESTRLCFEIVRCKLTLFYNYWQMNEVLDVLLPQGMIVPSAFETVGHIAHLNLREEHFPYKKLIAKVVLDKNKPKIQTVANKIDVIHNDYRTMQLEVLAGNHSLVTTVVENGLYFDVDLAAVYWNSRLATERQRLLSCFTYNDVVCDVFAGVGPIAISAAKKVNYVYANDLNPNAVEYLERNCVRNKLERKIEIFNMDGRRFIDSIFASEKARPITQVVMNLPNDAVGFLDSFRGIFRNKHTDKQFTLPRIHIYGFSKVQDPEFDFHEKIRIALSEVAFEVQMHRVRLVAPGKWMLCASFVLPETVAFAK
The following text describes a protein:
Function:
Binds galactose.
Sequence:
MAEPKSFNIPYRSKLTERIEPGQTLIIRGKTIDESKRFNINLHKDSPDFSGNDVPLHLSIRFDEGKIVYNAYTKGTWGKEERAKNPIKKGDDFDIRIRAHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQWGGKYYPVPYESGIAADGLVPGKTLVVYGTPEKKAKKFNINLLKKNGDIALHFNPRFDEKSVVRNSLVNGEWGNEEREGKNPFERLTAFDLEIRNEEFAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQVVNNQPAQE
The following text describes a protein:
Function:
Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Early endosome. Membrane; Multi-pass membrane protein.
Sequence:
MDQDSTNGGPPPAAGSLHLFADNLNGFLLAVAFIGAGFIVKKQGLRRAGASGSRAGVGGYGYLLKPLWRIGMVTMIFGEIANFMAYIFAPAVLVTPLGALCLIVWWDVRNLKACIGHRFKSLHCSGPIEDWYVDHPLLDDTITCPCIRQYGVSIHIIVYLGICSTIGSLTVMSIKAIGIAIKLILEGINHAGYFQTWVFAMVAISCIIVQLNYLNLALDTFSTAVVSPVYYAMFRILTIFTGAIMFKDWSGQSASDIASEICGLITVISGTTLLHSTSEADPPTSDLYAQLSPKMFWHIQGNGEMGKLEDNDMSSGEFVAVLRQSEDYVTLVYRLTRRMMDPEFSPNHAMQVYVGLNFMIDG
The following text describes a protein:
Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Miscellaneous:
MISCELLANEOUS: Blood stage antigen transported to the erythrocyte surface.
Subcellular Localization:
Golgi apparatus, cis-Golgi network. Endoplasmic reticulum. Cell membrane; Peripheral membrane protein. Host membrane; Peripheral membrane protein. Note=Schizont membrane, internal surface of parasitized erythrocytes and on membranous structures in the erythrocyte cytoplasm.
Sequence:
MDKSKSSIEKELNRIKQDVSLSAFSILFSEMVQYCLYKSKRGYRIEDCLHEMGLRVGYKLNEYLTYKNKVKRSINIINILTFISKHVWKYLFQHSSDLLKSQDSIYEYMICDKNILLNKFINVPKDYGNINCAAFAAGIVEGFLCSSEFQADVTAHTIHEGDDNYNTTIFIKFYPEVVEREKNH
The following text describes a protein:
Function:
Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Sequence:
MLEGTVDYDPLEDITNILFSKESLNNIDELISITRSYKKQLQEDILKEENELKEHPKNSAEIEASLRKVFQDFKETQDVSASTELTISNLTEGISYLDIAKKNLTHSLTLFQNLKILTDSYIQCNELLSQGSFKKMVSPYKIMCSLAENTFISYKSLDEINYLLSSISRLKGDTLSKIKQNYNALFSGGNISEHDTALTMELREGACELLDCDTSTRAQMIDWCLDKLLFEMKEIFRVDDEAGSLENLSRRYIYFKKILNNFNSKFADYFLKDWEMAVRLTTTFYHITHKDLQTLLKREFKDKNPSIDLFMTALQSTLDFEKYIDVRFSKKIKEPKLSSCFEPYLTLWVSHQNQMMEKKFLSYMSEPKYPSNETESLVLPSSADLFRTYRSVLTQTLELIDNNANDSILTSLANFFSRWLQTYSQKILLPLLLPDNIEVQDKLEAAKYTVLLINTADYCATTIDQLEDKLSEFSGNREKLANSFTKTKNIYDDLLAKGTSFLLNRVIPLDLNFVWREFINNDWSNAAIEDYSRYMVTLKSVLKMPALTDASIKQQQEQPSTLAFILSQFNRDVYKWNFLDKVIDIITTNFVSNTIRLLQPVPPFSLAGSKRKFETRTVVNIGEQLLLDLELLKEIFHTLPESVSNDSDLRENTSYKRVKRHADNNIDQLLKFIKLLMAPLDSADDYYETYSKLTNNNPDSAVWSFVLALKGIPWDLALWKKLWSAYNLETDDTDEGSRPDSNRDLFIFKWDKVLLGQFENNLARMQDPNWSKFVRQDLKISPPVMKRIVSTPQIQQQKEEQKKQSLSVKDFVSHSRFFNRGT
The following text describes a protein:
Function:
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.
Sequence:
MGRGRGSVASSIGGANGTSSGRGGGARRHRRAVTSRMGRGPRDDRVWWAEPEGRRVIDGRGRRNVERPGGRGRSTLEGGDVADGGGAYGTCGPRGRGPRSVASAVGVSRGKGARYKSVRRGRGGRRAAPLTLLVVPVAPVPAAAMAPARKFFVGGNWKMNGDKKSLGELIALLNGAKLPADADVVCGAPTIYLDFARQKLDPKIGVAAQNCYKVPKGAFTGEVSPAMIKDCGATWVILGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVISDNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSHVSDAVAQSTRIIYGGSVTGGTCKELASQADVDGFLVGGASLKPEFVDIINAKH
The following text describes a protein:
Function:
Catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Miscellaneous:
MISCELLANEOUS: Present with 2190 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSVADLKNNIHKLDTGYGLMSLTWRAEPIPQSQAFEAMHRVVELSRERGHKAFFNVGEFYGPDFINLSYVHDFFAKYPDLRKDVVISCKGGADNATLTPRGSHDDVVQSVKNSVSAIGGYIDIFEVARIDTSLCTKGEVYPYESFEALAEMISEGVIGGISLSEVNEEQIRAIHKDWGKFLTCVEVELSLFSNDILHNGIAKTCAELGLSIICYSPLGRGLLTGQLKSNADIPEGDFRKSLKRFSDESLKKNLTLVRFLQEEIVDKRPQNNSITLAQLALGWVKHWNKVPEYSGAKFIPIPSGSSISKVNENFDEQKTKLTDQEFNAINKYLTTFHTVGDRYEMA
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MDFQTPWNLVDENLDIEDLEEFDVPTHGNQRQKQKRNGRKTARKVQKRSRKSGQQEVASKKTKKAEPVRQPEEKYEEEQDQEEHKPEAQNPVKQLQEEQDQEEQDQADVPGQVALPDGVFLYKVQSLYRHGVDLHVRSDEPNVMEVIEKIFTEFYKNVLPRLPLQQPDWKAMDTTDLMEFLESFNFAAEKFKKEKPRSLLTAARWRKVHLQSDSFKEGHLITELARKLSVVDERVLKRHYKSFSEETYGATKTEQMKHMLDQLKVKNDDVIFDLGSGIGQLVTFTASYANVAMVYGIEKCDAPADIAARISENFKRLMKFFGKIPSPFELIKGDFTKPANKESIVKKATIIFVNNWLFGNELMRDLREILHLCAPGTRVVVTKLIDQTRFNKKTYVGHFNSFSHTAPLDSIDCPVEWTDKKFDFWVSRMDNEKVYNLAEHFRAEEEEQEAKRETKRLAKAQKAELNSHKFS
The following text describes a protein:
Function:
May play a role in the regulation of cytokinesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDIDIDTIINRSLHALENSEYSEFDLLLNQLSYLIKQSVNSNNKTASKEQITRILDYTPNNFNQVESLRLYRGLLILVRNFAPLLDIDLFPIVANSFEKFLKALNQTSEWTDRIIEVYWQILANFQRNEFTEVANEFFGQWESKYKWKDIPVSVMSPVIHFLFRQFNTQDPHITNENLLSLLKLFETNHVMNAVYEIFTMIDFADTNNIGHDNKMFIHLLYDIITHESFQKWIEQQNEEETITKWLSLTSVIVQTKTDWNNYELIALLSWNGSLFMKYAPLINSNCNTTVNGEDDFGYVEDDISAITAIFAELSQFNATKQYFEHYEDLLPKLIFVFKWIHDNIEPITIKSSKIEEVGRYSSVKTNIITILSYLSYDSFQFQEKIRELGGLSLVLSNCIIDNNNPFIKEQAIVCLKYLLQKNPKNQQFVADLEAKKVVDDQVLSEVGYQVEVIDGKVAVKRK