lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for preprotein translocation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSDPESPLWVATLLRHHKELKQRQGMFQSRHMEFFRFKRFVRALNSDEYRAKSEREPEKYPPVRSEEDARDVFVSLIKAQLVLPCTKLHTAQCREHGLAPSKDYPHLLLSTKATLDADEYYVWTHNPKTLTDYLTVVGVIVGILAFVCYPLWPHSMKRVVYYLSLGLLGLLAVFSALALVRFVIYVLSLAFCSERGGFWIFPNLFEDCGVIASFKPLYGFGETECYGYIKKQKRRKRKLEKKKQ
The following text describes a protein:
Function:
Required for hearing. Plays a role in maintaining cochlear stereocilia bundles that are involved in sound detection. Ensures the restriction of TPRN to the basal region of stereocilia in hair cells.
Subcellular Localization:
Cell projection, stereocilium. Note=Concentrated at the basal taper region of stereocilia in early postnatal development. In adult hair cells, concentrated at the basal region but also detected along the stereocilium shaft.
Sequence:
MEDSEKKLNQKSDDKPRKVRFKISSSYSGRVLKQVFEDGQELESPKEEYPHSFLQEALEPMDGVYGSGEVPKPQPYSPKLTAQRISVFRDSGAYTLAGSQPLFNDYKANDHKPPPIIDFGKIIIYTNNLKIIRTPMDKRDFMRKILQKEDVAEEASLMITGENDGDREQGCPLPERNGSPLPESERTFLHSQHTQDGLVPEDCLHCQGSGIATCSLCHGSKFSMLANRFKESYRALRCPACNENGLQPCRICSP
The following text describes a protein:
Function:
Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Midbody.
Sequence:
MSTGDLNGNVQRLVRELRSIKYPGDVDEVGLRLGDPVALLPLLSFTLLKFSRHVARYIVRNGFELAGKTDQRFVETSFRLLRDLLNVRTVLTPAQFFEQGFAERKVLLLCDVITVCKKLHNDEVRHERLAALKATRQEQVISRLATPHGGQQEPPSGGRHAAGRRSPVVKVVRNDDVELLQVLAPTHQPNATDGAQSVFRTRKTISRSPSPSPPNAVTMRAGPDHSRSRMSPPGRRGASGASDVLELTLRPGSRGVGAPAGRPSSAAAAQQQQQQQPIHAWFLNPAFDEGVEGSLDLGLGLGGAGGARPDSTAWWQQSAPTPAVMQPAAARSWQQNPYLAFARASPTKAAPQAPPGGDRSGAGAPGAAAAAAWPAEEDMAQRDQSSSRQPHTRSQHHQQQQYHHHHDQRQQQQQPASSSGVPGGSAEVSGTAGRGGSYQPREIDEWSFSQYFGPGKGPQSQRTQQQQQQQQADGVGTSQDLGGADYGQGGYGHDQDAAEPSVAGSGEDEREGYTAAALSDRDGRQTDGGHAARRQQQQQQQSQQQQRGGHALFGWQRSQQPSAAEEQAARAGPSAAAAHAAAASTQQRPGVGAGLGRAAPAASEGAGHGGQDWAVKLRQLEQETQQQVQQLRERLAATEAELEKCRSEARQARETLQAQVTVLEGRVRFLECEMELCVKRQPTPARPAAAGDGFGDSALYGASGAAARASPGAGAGAGAGRAAGSPGREPSPAAAAAVAPSWRFGAAEPQRPHSAGGALQLAGGRPSLAAGATDAGVSTGANAWAGQQQAGQAASGLRGPAGSPPRASSAEPTSGAAAAAAALARASAEWLRPATSQPAPATGAAVALRFSAAAEPSLLTSSTYTTDQALQHQQLHHPHPQQPAPPAARLQPLAPQPASLVGSTGGRVTAGLTPMPQPSFSFQPSSLMQQVAASAAAAPGEGPAPAQELAPAPPQAHGQRLMSSSVDSGATAGRRHGAAGAAGALGAGGNQHVRGSAESALSSSSAAAVAAAAAAASRLEAGGAAGGAAAGVAAGHVPAWRAQPSERAGVTGGRLGTGGGAVGGSILDGISATAPAAAAASTAGLSASQSVPAPGTAPAPPAALAAPGGMYTLQPASAGQPGTGTGGSAGGGAYRSTDDLINSLYVRYTEAQDFLQSIRRR
The following text describes a protein:
Function:
Probable transcriptional regulator.
Subcellular Localization:
Nucleus.
Sequence:
MSLIEGDSIYNLFQTQDLGIDFASSIVPDSPNKFKKNANVFNNFQQQQQQIQQQNKQSNGLIYNNNNNNNNNNNNNNNNSSSSNNNNNSSSSNNNNNSNNNNQNHNNNNNNQNHNNIQHNNAQSQVYINHNSNGSQQEEQLFSIYLQPEKENELNNSYHDNVNNNNNNNNNNNNNNNNINLNHAQQQQQQHHLPHGQPHNNNNNNQFYQIKNPMEEIYSSNGIVPNQEPNKKVEYMNEPIKQNHYNIVPESIFDVPFGVSSQTMLNVPSTNNANNNNNNNNNNNNNNKNINFKQPIQPNQLIPIPPHSNQNNNISLNNNNSNSNSNPNNNNNNSNNISTQINNLNNNINNQNNQLNGSNNGKKKEEDKSIKKRKFISSTPVKGENGGTTLIPTTDGGFNMDEERHQKRQRRLVKNREAAQLFRQRQKAYIQDLEKKVSDLTGTNSEFRARVELLNSENKLIREQLLYLRNFVTQAVSFSFPKGGSNGTNSPSGVADQFLNSILPPGLNSPLPQGILPAGMNLQNPMIMSAIAEAASKNSTFRQNIQGNLLGTPIPSPQSSLTSNSGNNSPNKPLNNNNNNNNINNNNNNNPSSPNNNLNNNNNISPNSSTSHQVPYLPQNTPPQQSTPNQR
The following text describes a protein:
Function:
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVTQLSSQSFIFPSPELALREPNGLLALGGDLTAPRLLAAYQRGIFPWFNPGEMILWWSPDPRAVLFPEDLHISRSMRRFIRHCPYRFTLNHAFADVISACATERDEGTWIGRDVQQAYCQLHALGHAHSLEVWLENELVGGLYGVAVGAVFCGESMFSRADNASKSALMVFCHHFTQHGGELIDCQVLNAHTASLGAVEIPRNFFLQQLSQLQFSPLPAECWLPQSLNFSSAMQ
The following text describes a protein:
Function:
Could regulate export of the bud site and axial growth sites selection protein AXL2 and possibly other secretory proteins from the endoplasmic reticulum in COPII-coated vesicles. Seems to be required for axial budding pattern in haploid cells.
Miscellaneous:
MISCELLANEOUS: Present with 7110 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Resides in the endoplasmic and Golgi compartments, and then packaged into endoplasmic reticulum derived vesicles.
Sequence:
MGAWLFILAVVVNCINLFGQVHFTILYADLEADYINPIELCSKVNKLITPEAALHGALSLLFLLNGYWFVFLLNLPVLAYNLNKIYNKVQLLDATEIFRTLGKHKRESFLKLGFHLLMFFFYLYRMIMALIAESGDDF
The following text describes a protein:
Function:
Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains.
Sequence:
MFRKLTTAFNSRCALSRSFSVCELSKEHQQVQQLCRQFSERELKPAASAIDRNGTFPEQHIAKLAELGLMRVTVAPLYGGSGLDMLSLSLVVEELSRGCGSTGSIVSIHNCLYANLLHRLGTDDQRARFFNKYESKTIGAFALSEAGAGSDVAAMTTRATRDADGSWILNGTKAWVTSGIESVAAIVFATVDPALKYKGITAFLVDFDSGALAGVHRGRPEDKLGIRGTSTCDLMLENVRVPEANVLGTVGSGMRIAMEQLDRARIGIASQAIGIGQAALETAVEYAKQRTAFGGTLIDLPAVRTRIAEMGTRLEMARLLVRKAAGEIDRGLRATKACSMAKWIAGETATYAAHGCQQILGGMGYVKSLPAERYYRDARITEIYGGVTDVQKAIVADQIIKELE
The following text describes a protein:
Function:
Transcription factor involved in senescence, biotic and abiotic stress responses by modulating various phytohormones signaling pathways (By similarity). Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Required for the resistance (R) gene Mi-1-mediated resistance to potato aphid (e.g. M.euphorbiae) and root-knot nematode (e.g. M.javanica).
Subcellular Localization:
Nucleus.
Sequence:
MEDFLGENPHNRLIKELVEGKSFTVQLQTLLKQPNESVLAEELIRKIWGSFTQAITVLNSLGNSDNSLTQGQIEEVDQPNSGSELKKKKKEKQDRRGCYKRRKTSGSWMRESATMNDGCAWRKYGQKKILNSKYPRCYYRCTHKYDQECRATKQVQIIQENPIIMYHTTYFGNHTCNPTKIPKHTYNNHAMVKHSDSTVLKEEEEEEESKGQSDNASSIVDSNLWQDFMPSSPSAHDSTMAANYNSSYYEEIISSHDMEDWAKFGEIEAIEFC
The following text describes a protein:
Function:
Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.
Subcellular Localization:
Secreted.
Sequence:
MGIESFHPCNDITAPYTLEKHGVCQDAGQLWVPDLAGLQACYDLVWVGVTLGHYCLQVFCFAMGWPWAPLTAFWALGIVGATALRIGAFNVQSFGDHKASDPDCGSVIAQILAGYDIALVQEVRDPDLSAVSLLMEQINSVSKHEYGFVSSKPLGRDQYKEMYLFVYRKDVVSVVSTYQYPDPEDAFSREPFVVKFSAPGCGELIPPPPPSYRLSLTLTSPLSTAAKELVLIPLHAAPNQAVAEIDALYDVYLDVIDKWNTDDMLFLGDFNADCKYVKAHDWPSIRLRSSQVFKWLIPDSADTTVGNSDCAYDRIVVSGAHMRKSVKPQSASVHNFQEEFDLDQTQALAISDHFPVEVTFKPH
The following text describes a protein:
Function:
Essential for respiratory growth and required for mitochondrial protein synthesis. Required for vacuolar acidification.
Miscellaneous:
MISCELLANEOUS: Present with 1670 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MAQNFGKIPSHKSYVLSLYRTVLRNIPKCCHSYAFQYEIKKTLSIQLFKHKHDKSSWSVYTLLNEFSLLNNCLLEGKLQEIKNLMKPLKKMKKQLKTTKILNSLTSLGDVKTNDPEEVRRFHVLSAYIKRKQDLGLLPAYIPKTYQHKLLLPLALNEHACLKLFHIQQKLKNGPPSAGLSYTKEGRNQIWFVRSPINKGRQQSKKLGILIRKERKDSQKNIDNLNFCEINAAWALHEAIWEEYLESKKIIKVNLPKYLEYAANIPKSTKCNPSSQYQKVKEWVDPVREIMFELHSKSFQRVEYFNKYKEKLLKNGGQLAYFDKKSKEMYAKRLTLFRKMSKETLPYVTLFIEGRDLPSVLAKYGF
The following text describes a protein:
Function:
May play a role in cell viability.
Miscellaneous:
MISCELLANEOUS: Suppresses clear cell renal cell carcinoma growth and metastatis. In renal cancer cell lines, interaction with SLC25A11 maintains mitochondrial glutathione and enhances mitochondrial metabolism. In renal cancer cell lines, interaction with AGK promotes AGK mitochondrial localization and inactivates AGK-mediated AKT phosphorylation, leading to inhibition of AKT signaling and repression of metastasis.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MYRNEFTAWYRRMSVVYGIGTWSVLGSLLYYSRTMAKSSVDQKDGSASEVPSELSERPKGFYVETVVTYKEDFVPNTEKILNYWKSWTGGPGTEP
The following text describes a protein:
Function:
Involved in the formation of the dorsoventral pattern. It inhibits nuclear translocation of the dorsal morphogen in the dorsal region of the embryo.
Subcellular Localization:
Cytoplasm.
Sequence:
MPSPTKAAEAATKATATSDCSCSAASVEERGPVNAANPSSTXATSGKIGGKTQDQTAAINKPKEFAVPNETSDSGFISGPQSSQICSEEIVPDSEEQDKNQQQSAPQKEQPVVLDSGIIDEEEEHQDTTTATADSMRLKHSADTGIPQWTVESHLVNRGEQLNNLGQSSSTQITGRSKFQSSTASTANANPSGXGATSSAPPSSINIXNAWEQFYQQNDDGDTPXHLACISGSVEVVAALIRMAPHPCLLNIQNDVAQTPLHLAALTAQPNIMRILLLAGAEVRDRHGNTALHLSCIAGEKQCVRALTEEFGATEIHEAHRQYGHRSNDKAVSSLSFARLPADLEIRNYDGERCVHLAAEAGHIDILRILVSHGADINAREGKSGRTPLHIAIEGCNEDLANFLLDECEKLNLETATYAGLTAYQFACIMNKSRMQNILEKRGAETVTPPDSDYDSSDIEDLDDTKMYDRFGDPRYFVSYNGGNPMTVA
The following text describes a protein:
Function:
May play a role in cellular adhesion.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAAAVTIPGPRIGALQSSGLTLLLSLAAHCSGPQAKVLSPGGLDASGANLWASANCSLLQGFWCQPASQLPRDQLSALIQRLALLQVPLQAWQLSCLANLASRCGLQDDFTLHPPNLLLFYNLSQVREADCRAFIRRAAQGDVELLSHLPDQRVALWRAAVACLVGAGLRLSASDQQLLGALVCDMDASSIGAADPHMLENLRRCPRLTAAQRIALNSLLAGGKTSLGPPGSWTLEGLQALGPLATYISPHLWAQVQEAVGLGFFRSVVASCQVGRLGQREARCFVTSFLESKTKPVSSRPRLSTGNITAATLRDDLFLVHYDCAELESCLDGCILRTNLDTLLQHLLPTECQHVVKAKLAQIYPQGLPEDQLRLITSLVYLYSRTEIGQWSITSQDTVMALLASDVALENQTEAVLQKFLEHNGTVSGALLLAIGGTRLCWMSPHQIQTIHPQELRLAGALDLSSCPQSRKDVLYTKAHETFGSSGTLAAYYRLMRPYLGGSPGGAQPPSPVPPGGAPVEELRHLAHANISMDIDTFTSLNPLELQSLDVGNVTALLGHNVGDLQKARSHPTVRAWLRSLNSSTLGQLGLDASPTSPTGPAHGTRGPPSTTHQVLHLVHTSGLPTNDAQASTSGSLWAPLGYLPLAMALPCSLLCLLHWGTCILVSVDSVASGWLGSQGSGAGKTEVLDSAGRPLGLTGQL
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MTTTRTRTMRMRMDNDQALVDLDLSQAVKSTEPADWKYIAEGAANLILAYHPALLETEERLLRGKSLRLTKTTSRSHPEDKEKTQEQIEPARSKQISFFDFHHQILSEIISPDLLLQFDLISLDNQWLQGLATAVEPSRPSTKRDQSSIDTTRTHAIIMDNLAHQSDGSEQQIISVEIKPKWACLPHNLDLLEPSTRETKSKFCRTCVFRAVRSVEAAQDPAASEPLDEYYTSAHRFCALQLFNSRHPAHLRRALDRLCAEWQHLKPPTSTIPPDPEISKNTQAHNNFKIFRHGVLLDPLSVEVDPELIEVLAETLERSGVLRRLAELQRRLDKLDIEGVFKELGSKHKEGEEGAEVLEAPIGLAELTALIPLMSETMAPETVQQTLDGQSARTKAVMYALSMTFKDCSIFVRVPVLPSHTNLNPTTSTLLLSPAPEARLPQRTQVKIIDLDLKPISRLHKYFKADRTSFSDFITLLLRSSQSPPVTCLELCNSTASW
The following text describes a protein:
Function:
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (By similarity). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of TEL1/ATM and ATR upon DNA damage (By similarity). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (By similarity). Within the complex, rad50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of rad32 (By similarity). Rad50 provides an ATP-dependent control of rad32 by positioning DNA ends into the rad32 active site: ATP-binding induces a large structural change from an open form with accessible rad32 nuclease sites into a closed form (By similarity).
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The zinc-hook, which separates the large intramolecular coiled coil regions, contains 2 Cys residues that coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another rad50 molecule, thereby forming a V-shaped homodimer.
Sequence:
MSCIDRMSIMGIRSFDNRSRESIQFFSPLTLIVGQNGSGKTTIIECLKYATTGILPPNTKGGAFIHDPKICGEKEVLAQVKLAFRNTNQVKMICTRSLQLSVKKTTRQQKTLDGQLLILKDNERTTISNRCAELDSQVPLSLGVSKALLDYVIFCHQEESFWPLSEPANLKKRFDEIFESLRYAKALDQIKGLKRDQETQVKVDQATLTHYRSDKERAEKIELRVHESLKRISCIRSKVEELDQEITETARLQDELFKSTEEYEQQMITIRHLESQSDIINTTINDLKSQMTITDESSEDLEKLHSNFAEKVKEEQELYKSLEKKRSDLESLLKSRRELLEKLTGDLGKIQGEIESLEKLKVKKSTMINEIVHRYNINEINEEGIMTEVSKYASLVNKNYEISSGKLKERQVAVRARIEGIKAHEMFLNNRVSEINSSLEKQLTTQKELRSRFEILFPVKLQREDFTKDVEKSDLWIKSLRQEYESKNLLELLDKHQTALSSVENRLDEISEIVDSYHKYSGVRTKLQVFEENKTNKSAILANQLMTLKSSFSEVMSYELKDDDNYNEELDKLVEDVRKKLQEKEEAESSLRSVRERLEIRISLSVQSINDLTENKKIKTKTLKSYSGTFASMISEIKALESEIEENRKTLHSLQFGSTFYEKAIEICVDQHACQLCQRSLDKEEEKLFVEHCHSMIDVIPSKSAEVYSHLETLTKTFKNLSEAKPIFDEIELLDKRLSETKTELSDLQGDLQGLDIRKDEIQSELDTLYLRRANLEKLQLLVKDISNLEEEIRTIDRETEVLRIELPSSIAHHNLDEIYAEREKLLEKRGYLRKQIERTKLEETSFKKKIDDAVLANNEQKLKLTKLNFQVNELEQLEKDINKSSEDCDLQKKKLLEVSSKQGSQAPFLNELESEYEKLEADIQEMAQKSRTEILEANEYLHQLNEWNSELRIDVSTKFKCIKEKKSNIGEEVRIIASKIESTDDNLRKLQERLADLRTRERNASDNLRLRALMRQLEEAVTQKNYLLSQQSHDDRESFRERMQILKSKYGALNAERAGLLGECKQLENSITKDKEELNMEFKDADERFRRQLIKTKTTGKANEDLGKYAKALDVAIMQLHSMKMNEINRIVDELWKQTYCGTDIDTILIRSDSEGKGNRTYNYRVCMVKGDAELDMRGRCSAGQKVLACIIIRLALAECLGVNCGILALDEPTTNLDEENICSLAKNLSRIVEFRRKQANFQLIVITHDEQFIRLVNSDAYCSYYYRVKRDTNQKSMIVKEPL
The following text describes a protein:
Function:
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Subcellular Localization:
Nucleus.
Sequence:
MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNAENEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEVSLIHLTFPSSTCASI
The following text describes a protein:
Function:
RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities (By similarity).
Subcellular Localization:
Virion. Note=Minor amounts are incorporated in the virion.
Sequence:
MSDIFNSPQNKASILTALMKSTTGDVEDVLIPKRFRPAKDPLDSPQAAAQFLKDNKYRILRPRAIPTMVELETDAALPRLRQMVEDGKLKDTVSVPEGTTAFYPKYYPFHKPDHDEVGTFGAPDITLLKQLTFFLLENDFPTGPETLRQVREAIATLQYGSGSYSGQLNRLLAMKGVATGRNPNKTPKTVGYTNEQLAKLLEQTLPINTPKHEDPDLRWAPSWLINYTGDLSTDKSYLPHVTIKSSAGLPYIGKTKGDTTAEALVLADSFIRDLGRAATSADPEAGVKKTITDFWYLSCGLLFPKGERYTQVDWDKKTRNIWSAPYPTHLLLSMVSTPVMNESKLNITNTQTPSLYGFSPFHGGMDRIMTIIRDSLDNDEDLVMIYADNIYILQDNTWYSIDLEKGEANCTPQHMQAMMYYLLTRGWTNEDGSPRYNPTWATFAMNVAPSMVVDSSCLLMNLQLKTYGQGSGNAFTFLNNHLMSTIVVAEWVKAGKPNPMTKEFMDLEEKTGINFKIERELKNLRETIVEAVETAPQDGYLADGSDLPPIRPGKAVELDLLGWSAIYSRQMEMFVPVLENERLIASAAYPKGLENKALARKPGAEIAYQIVRYEAIRLVGGWNNPLLETAAKHMSLDKRKRLEVKGIDVTGFLDDWNNMSEFGGDLEGITLSEPLTNQTLVDINTPLDSFDPKARPQTPRSPKKTLDEVTTAITSGTYKDPKSAVWRLLDQRTKLRVSTLRDQALALKPASSSVDNWAEATEELAQQQQLLMKANNLLKSSLTETREALETIQSDKIIAGKSNPEKNPGTAANPVVGYGEFSEKIPLTPTQKKNAKRREKQRRNQ
The following text describes a protein:
Function:
Serine/threonine protein kinase required for spermatid differentiation and male fertility. Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4. Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
EIYTFGRILGKGSFGMVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELREILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVIMYMLLRGEPPFLASSEEKLFELIRKGELHFENPVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNKPSTEEKLKSYQPWGNVRDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSSFTSSKLLPAEIKGEMEKTPVTPSQGTATKYPAKSGALSRTKKKL
The following text describes a protein:
Function:
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MMWSNFFLQEEERRRRGGGLRGARGKRGPGLAPALEGQIKLALLLTGVGATLAVLAVGTEFWVELNTYRANGSAVCEAAHLGLWKVCAKRLWQEDVPSGRATCGPAELPGEANCSYFKFFTTGENARIFQRTTKKELNLAAAVLAVLGLGVMTLGCLCVIMVLSKGAEFLLKPAAICFSLAGVLLLVSLEVFRHAVRGLLEGATPTPAPALEYEYSWSVACALAAGTVLFLGGGCFLLLALPPRPWKAPCLRRGDGDT
The following text describes a protein:
Function:
Has carboxymethylcellulase activity.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
GVQISQISSFPTTADVSYDFNITNALGGIQPVGSLK
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.
Subcellular Localization:
Endomembrane system. Golgi apparatus.
Sequence:
MFERTLQDLIRGLRAHKGASKTQEDAFIAEAMTEIRDELKGKDMALKAEAVIKMCYLMMLYPIPPPAGFAFHVVEVMSSPRYHLKQLGYLAAPMAFSGDTEEIVLTVNGIKKDLLSPHVPLPPLPLTALPQLLSLSSSLSTSLHPDLLHLLTHSSPRIRKRAVLCLLPCWEAFPEGLREGFPRLRERLQDEDQGVVGATVGVVMELARRQGGKNYLPLAPELFGILTGSSNNWMLIKVVKLFAILTPLEPRLVRKLLPPITTLISNTSAISLLYECVRTCIVGGMLNADRPEADALARVCVEKLGGYLRDEGGDQNLRYIALLAMVKIIPTHPQLVAEYQDEVLQSLDDPDVSIRMRALELATNMVDPNNLQTIADTLLSHLAPVSPVLPSAAASLAAIASSSGTSSNALPSLSPAYRHLLSTRLLAILSHNTYANVTDFEWVLSVLVDVAYVSRVNVSQDIKKMILDVVARVKSVRNYAVSVLEKVLGDDDFKERLGDDNESADGLIEAAVWVCGEYPSELSSPLSAISNLLSPSTSTIITSLSIQAVAKIFGYYCTIAASSWSGDKFEETKALVASIDKGLTEVERNAKGDMEVVERVGEIKGLLGFVKADLEHHLPPQNTLRRDSGSSIPELEGGFEAEAKQTNQNDPPYPKSLYIFPPLSTSHPLNAVASYAQSSIRIPEGLDLDTDLVPGGGWPEDIEEVDESEEEREKGLLNLGEGGGEGMEELRRVLREGRKKKKGKKGEEGEDRVERERRRAARRAKHKNDPYYLYDREDEDVDNIPIVKLDDSELPHDITDPSSRPKSKSRQKKKAPPEFDRTGELPEGVSSPQIPTPSSRLSPSASRMNSTTGLAAVDLSASGSMSKPVSRSSSRFEEYKLHEEEGLSGATSQVDFQRNGGEDVPVASVPEVQVVKVKRKKKAGEKKKKKEGKRESPAE
The following text describes a protein:
Function:
Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. Demarcates the prospective midbrain-hindbrain boundary (MHB) region in the neuroectoderm in early gastrulae embryos by repressing transcription of a number of target genes.
Subcellular Localization:
Nucleus.
Sequence:
MHSPGICPQAAGCRMRNSYPNREDKRLMKPVIEKRRRDRINQSLEHLRTLLLEATHDETLKNPKAEKADILKKTVHFLKMCHNPVPSDGKKLLSGFKGGFREGLNQATSFLNSADSICQKKKEYVVQRLCQHMEQQTQKHCHDSAQDVSSRVNQRQILPSPPLISRVTGNGLEQSPETQTSRPPHSHHPSPSSSFRTPCMGQEQQQTPPQTFQANTNKKPTQRTLFPPTSSSVNSALVWRPWP
The following text describes a protein:
Function:
Binds oxalate.
Sequence:
MKEGTGMVVRSSEITPERISNMRGGKGEVEMAHLLSKEAMHNKARLFARMKLPPGSSVGLHKHEGEFEIYYILLGEGVFHDNGKDVPIKAGDVCFTDSGESHSIENTGNTDLEFLAVIILL
The following text describes a protein:
Function:
Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT) (By similarity). Mycobactins are then reduced by the siderophore interaction domain to facilitate iron release in the bacterial cell (By similarity). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity). Required for replication in human macrophages and in mouse lungs.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
In IrtA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused. In addition, IrtA contains an N-terminal siderophore interaction domain (SID) that binds FAD.
Sequence:
MARGLQGVMLRSFGARDHTATVIETISIAPHFVRVRMVSPTLFQDAEAEPAAWLRFWFPDPNGSNTEFQRAYTISEADPAAGRFAVDVVLHDPAGPASSWARTVKPGATIAVMSLMGSSRFDVPEEQPAGYLLIGDSASIPGMNGIIETVPNDVPIEMYLEQHDDNDTLIPLAKHPRLRVRWVMRRDEKSLAEAIENRDWSDWYAWATPEAAALKCVRVRLRDEFGFPKSEIHAQAYWNAGRAMGTHRATEPAATEPEVGAAPQPESAVPAPARGSWRAQAASRLLAPLKLPLVLSGVLAALVTLAQLAPFVLLVELSRLLVSGAGAHRLFTVGFAAVGLLGTGALLAAALTLWLHVIDARFARALRLRLLSKLSRLPLGWFTSRGSGSIKKLVTDDTLALHYLVTHAVPDAVAAVVAPVGVLVYLFVVDWRVALVLFGPVLVYLTITSSLTIQSGPRIVQAQRWAEKMNGEAGSYLEGQPVIRVFGAASSSFRRRLDEYIGFLVAWQRPLAGKKTLMDLATRPATFLWLIAATGTLLVATHRMDPVNLLPFMFLGTTFGARLLGIAYGLGGLRTGLLAARHLQVTLDETELAVREHPREPLDGEAPATVVFDHVTFGYRPGVPVIQDVSLTLRPGTVTALVGPSGSGKSTLATLLARFHDVERGAIRVGGQDIRSLAADELYTRVGFVLQEAQLVHGTAAENIALAVPDAPAEQVQVAAREAQIHDRVLRLPDGYDTVLGANSGLSGGERQRLTIARAILGDTPVLILDEATAFADPESEYLVQQALNRLTRDRTVLVIAHRLHTITRADQIVVLDHGRIVERGTHEELLAAGGRYCRLWDTGQGSRVAVAAAQDGTR
The following text describes a protein:
Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Sequence:
MQEAGDSKGRRSSFHGGSSSFLKNLNSLLKLKKSPGRPAEGAEPANEPHLGDNAKERDRGLCTRPPGPVSRCSTGTVYRSPSHRRQGSSASAKREFKPSHATAVQHASHCCNCMLRGMQPPADSPAERGVTRGEAFANPVCSRGLESKSVPPYVYDSRLPASAIPWHTKDSSTDQLPRISVDVLAAILDGKFSSHYSEVYIIDCRFEYEFQAGHIKNAINVSSRRELEAEFIQKRIQRCSADPGRPPLLVFHCEYSSYRGPIIAAHLRNYDRILNHGQYPRLHYPDIVVLEGGFKSFIEAFPGFCQGHYVGMDSYVNHELELARFKRDSKTILTRQNSQHIFQEQGQEGGHGLAGRAYQPDPVATLLPTRRPSFSFDAPPQSPSLVIGGNSGSSACSCSSSTRSVLTGKMLLMHDLTTDVKACDKDDQDDQFSFDLGDELAITVEDLFSSPVGRRLFPEIVKEEDNDS
The following text describes a protein:
Function:
May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
MATKRAYKLQEFVAHASDVTCAKFGKRTSRTFITGGEDQKVNLWAVGKPSAVLSLSGHTSPVESLSFDSSEVMIGAGAATGTIKIWDIKEAKVVRTFTGHRSNCASLDSHPFGEFFASGSSDTNMKIWDMRKKRCIHTYQGHTGRIDVLRFTPDGRWIVSGGADSSVKIWDLTAGKLLHDFTLHEGPINCLDFHPHEFLLATGSADKTVKFWDLETFELIGSSGPENCREYYMPASVVRSMTFNSDGKALFCGLHESLKVLSWEPIICHDAVDVGWSTLADLNVQEGKLLGCSYNQSCVGIWVVDLMKFDPFTVGSAEAFWNGTGNGPLQADNSISSMLGSLSISRRQEANETSSTLLKRPMSASKEASVPASSAVRKRLSKAPGINNLRLTRAESAPLISPRVRLKPDSTDHQKRHIANVRFKVDLSTSARMIAGNSQASAAPTYIPRSNIFACSSEGSTFVPGIVPRHVSKVDAGSNLSEAAAAAIKPEQLLKGHLAVDHDKDVHRSIFQSKPITSKTPQRKFIRETSSDGDINCFGALCTESVQSNKVDNWYDVCGFEETKSAVGRNPQFVNVNRTVVFGSSQLVESSESSIMQNRGTGHLCASYKRSEYAPTSDGLRQSSFAGERSALANDDDLIADLMQNHQEFIHAVKSRLTKLELVYRCWQNNDIKGSVSAMRRMSDHAVTADIINVLIMEKSTKYITLDICTSVLPLASNLLESGYDRHLNVALVTILKLVKSFRASIFSTLSSTPPVSVDLEAEHRLERCSICFQELEKINAGLISLTRREGKVGRSARELSLLLQDIFKTPSSV
The following text describes a protein:
Function:
May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).
Miscellaneous:
MISCELLANEOUS: Might carry two S-adenosyl-L-methionine binding sites with only one binding to the iron-sulfur cluster.
Subcellular Localization:
Mitochondrion.
Sequence:
MINKIVKNVIENQFKGYNKLKDLPISLFVYWPYCSKICPYCNFNKYRDSDKVDHERMSKSLSRELESFVKNIYLNSNENSFIRERPITSIYFGGGTPSLAKISTFVETIETMKKLFPSSLSIEDIEITLEVNPDQKDLKNLLKDFKKYVGVNRVSLGVQSLVDKDLHFLGRTHNRIQAEESIKIARDLFDHVTFDLIYSRTIDQTLEQWRNELRYALNLADGNGHVSLYTLTFEQGTSFYRRLSSKGNKFKIIPPDDQKSSDLYDLTVCEAEAMGFQQYEISSFASSHNQKGKHNLNYWRSGDFIGIGPGASSRLTTLNNNNNNNNQISRYSFKNILHPKEWMEKLNSKEILCNAFIEDEFNPTIPLTNFEVAEEMLLNGLRTIEGVQLSTFTFQTNGLTFDQFLNMKQVEILQEQGFLILEPTCLKLTGNGRKLLDTIIPKILKY