lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Binds independently on SAGA to promoters in an RNA-dependent manner. Binds to mRNA and is essential for total mRNA export from the nucleus. Required to counteract heterochromatin silencing. Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe. Required for expression of ecdysone-induced genes such as br/broad.
Subcellular Localization:
Nucleus, nucleoplasm. Cytoplasm. Note=Localizes to nuclear periphery, in contact with the nuclear pore complex (NPC).
Domain:
The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module; The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of not/nonstop forms the 'catalytic lobe' of the SAGA deubiquitination module.
Sequence:
MANSNTNQLHPLGATTSQTFITALNHTAASTIAINFRELIKEPKELDEASNYLYQALLDDVVAGIFIETHHLRKTGNLAALDGVGEENLESAFHICEMPNLDIFGISTAKKQMDCTCPNCDRLVAAARFAPHLEKCMGMGRISSRIASRRLATKEGSSASTSSTSTYLQSGGNTGGTDDEDDVDWSSDKRKKKSTQSSRNNGSKKNNGKTF
The following text describes a protein:
Function:
Palmitoyltransferase specific for Ras proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MAFQFSNNPESNETTNNPAPHVLGLPRPPSVGGISSRVTDMSEDGDQSQTNTMSSHVPHRHSVSRRGPPPARSSIASTSQITNRPGSSASRLSRTHIPSLAASGFFRPMSSQRLQAHRGRPATNHTVSTEDWGDQMNQNRRSLISNSTFPNSLSAADQEVPPSRGTEFTDPIIPDRIHSNASPTANTTTVRSESANLIRDRERPPHLNLKVDYKGTNENETPERSPLSFLSLQNRNAPADNRDSRAHARLSSADSSPQSIEKKPELAKSRNKGRNYEYFVGNTIFLGGGRFQNSRDKPVNIATGLLVLVPTGLFFGFSGPWLWHNISPAIPVLFAYVFYLCFSSFIHASVVDPGVIPRNLHQMPPVDPSQDPLAIGPPTNDWVMVKLATSDVAAMDVPVKYCKTCSIWRPPRCYHCRVCDNCIETLDHHCVWLNNCVGRRNYRYFFAFVSTSTLLALFLLGASLAHILVYRSREGISFSDAIDKWRVPFAMVIYGALAAPYPASLWAYHLFLVGRGETTREYLNSHKFAKADRHRPFTQGNVIRNWIAVFGRPRPPTYMQFKEYYQEGDQRLSTVKRRFLPRNTEPQNDIEMQHVPPPNSA
The following text describes a protein:
Function:
Chitin-binding protein that is important for the longitudinal contraction and lateral expansion of the larval cuticle during its conversion into the oval-shaped puparium case. Essential for survival to the second instar larval stage. Confers the orientated contractility and expandability of the larval cuticle by regulating the arrangement of chitin and the formation of supracellular ridges on the cuticle of third instar larvae. Essential for determining pupal body shape; required for the orientated shape change of the cuticle during metamorphosis which involves changes in the morphology of the supracellular ridges; [Isoform A]: Mainly involved in regulating pupal shape; [Isoform B]: Mainly involved in larvae survival, possibly by maintaining the normal morphology of the larval hindgut during development.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MAKILISALLCVAMFGSMALGSPECPTPNGRFASGDQCDSYTECQDGTPVEKLCPDGLLFHQRTKATGECTYAPYSTCKERARLQPANGTEECPRQFGFYPNGDATKCGVYRNCAHGVASLTKCPEGLAFNEETYQCDWPDLVESCNAEAYLGFNCPAADSADDSAAAAVDVSPEGELRYYRHPQTCKKYFVCVNGHPRLYNCGKYLAFNSQTKLCDFYNKVPECYALLKEKQRLKAEKQQPQVAQPED
The following text describes a protein:
Function:
Negative regulator of the dra-nupC-pdp operon. DeoR binds cooperatively to the operator DNA, which consists of a palindrome and a direct repeat sequence located 3' to the palindrome.
Miscellaneous:
MISCELLANEOUS: Deoxyribose-5-phosphate is most likely the effector that modulates binding of DeoR to DNA.
Sequence:
MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYAKEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYMHETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLFAEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALLFRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSILVAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDAFIALSIINVARGSFVTIRYGLVARIPGFHPGGSGSIPARASSVPVLALECTVQSWAEVVTVTRETNRLPTGLLDVGASVTSNCCVVDDTDVFFMAAIRLWDEGREPFIWTSDFALASICMMHLAIDRNKSLLLYLSERTPHDASYTSPVIGAVAPASRKPGAFMHLPSYVMFYYNYLIYAILKIIRAKYKDLNKALKKGVISSKQIETSLFNLKEIVDTFNKIFGWPLLFIIFTSSIIFLDYTDEFFNGKIFALEGRKFGMALGSYVSMALLTSYGAIVVILLCDYIGEEMTKVEERLFKLKRASSEKEISSILVNVRYTFPKFSAAGFFVIGKSTILTVLGTVVTFLVIMVQFKENK
The following text describes a protein:
Function:
Involved in the import of light-harvesting complex proteins (LHCP) and subsequent routing of these proteins to the chloroplast signal recognition particle (SRP) pathway.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASIPCTGVAAAAAAITSKSFPSSTKFNTRFVGTRNRLGWVRPLGLGPSNGSRAKCWFKFGKNGVDAEGAGIYGSQSRDDFDRDDVEQYFNYMGMLAVEGTYDKMNALLSQNIHPVDILLLMAASEGDKPKIEELLRAGASYSIKDVDGRTALDRAASDEIKDFILGFSVQKA
The following text describes a protein:
Function:
Directs RNA polymerase II nuclear import.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
RVQRKRGGAEPAEALLLACKRLRAEPGQGAPVERGVFKLVATVSSKVPPGSSGRRRPRGWNEPIQKYVQEGISKDKAVQSLRPSLGSTQRVVQELRSSKQVRRKENRYRVVASHRPGSSGTAAALTDCEAVRDGGRSAPAAAGDALQQESGAVDKSLDCGGNFQLFDIVHEEEVVEDSSFTAANAQQTGDPDVILCNAVEMIRERLNVSEDHNKVGHREKDEYVYDIYCMETSAPGWIQNILSVQPYKEEYELVDDDQVPAEIYEDEDDENDEDNWRNDYPDEDEFLAEEDDEEKDSEESSSDEDQCYRRRTWNKYRQEVLQEFGYDEIQDLDSD
The following text describes a protein:
Function:
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
Miscellaneous:
MISCELLANEOUS: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.
Subcellular Localization:
Cytoplasm.
Sequence:
MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPTLEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGYAANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIGHAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELRGGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGILFEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVIFSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MVLIHHNIVDFRLHPKGYVEYIIDADRVLYMLRYPRYTHCAKTLYGDTGELIVEELLQNGRMCMSSVLRKVLGRLQGSHTAEAVRSKFVDLVQTHFLCRVPAPEPGGPDAKVPTLILLEEDMYSVPKASPSPSIAGSQPTPPVHLQLLSVAAEDEDQEGPPSKKSRVESQPDEGIYWQVNFERFHLFFRDQLLVQAASRRLGLKAGEVVRTLLRLAETRTHPKSAQSCPVSKQEVHQQLHKEISLSQKELDSFLSLLVEDPLRLVQRSDERGGMFCVDLHRGLRVLAEAFFASTVQDRFGAKSCRIFRWARELPRTPDYAPSRMIYLFHVDLPQLSRQMLEWCCQAVCNLVLRREHICQEHRRLLDKKQRVDLILASMEHNKASPEQVHEVKEMITPPERKQLAYVKHVSSKMELSEVQLDETMLLLQLYVSSLLK
The following text describes a protein:
Function:
Has apparently no steroid dehydrogenase activity. Controls bile acid (BA) and lipid metabolism in response to nutritional cues.
Subcellular Localization:
Mitochondrion. Peroxisome.
Sequence:
MQGQVRAASRRPQPGGGCDRGRLREQARTAAPSVLRAQEPGAGLGPGREPAGQPLQRSGPRALHEVPRARLQPPPHARTPAPAPAREKRTHVAADARATPVAGGTPIVPAEPRDARGAGPPFFLSACAERARPAAGRGRGRRKLAPSAGARCVRRRTPRAAAPGSARSPPASGRGLEGPGLNEERRPASPGPLAAAAVAAASALRKPCYPTPVEAAGGKALPCSVDVRDEQQISNAVEKAVERFGGIDILVNNASAISLTNTLETPTKRVDLMMNVNTRGTYLTSKACIPYLKKSKIAHILNLSPPLNLNPMWFKQHCAYTIAKYGMSMCVLGMAEEFKGEIAVNALWPKTAIHTAAMDMLGGSGIESQCRKVEIIADAAYSIFKRPKSFTGNFIIDENILREEGIKNFDIYAIKPGHPLLPDFFLDEHPDIIIKKAESRDVIPELKEEKPQPPPKQRSGAVEETFRIVKDSLSDDIVKATQAVYQFELSGEDGGTWFLDLKSKGGNVGYGEPSNQADVVMSMSTDDFVKMFSGKLKPTMAFMSGKLKIKGNMALAIKLEKLMNQMNAKL
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MAKILIIGTGGVGTIAGLSLTQHGNEVTFVVRSNFEELKKTGYNIESCDHGDQTNWKPHRMVNSVQEAIANDKNYDYVLVAMKALPDVFSTADIIRPVVESSPNVAIVLFQNGLNIEEPIVKAFPNNVCVSGVSMIGSTNLGAGEIHQAEPDYVKIGYFDNGSDKAPQEKRAKEFVQAYGPKFAHYVDDVVYHRWRKLLYNATFNTICSITRMDSGRLWLNGVSDSLIRPAMGEIRAIAKADGHILTEEDEDYMIDSDGEVYYKPSMLVDVEKGNLMEMEVILKAPLDVAKKYNVPTPILSVVYELLKCLQFQLKEAKGMVELPEKLERKSALH
The following text describes a protein:
Function:
Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MANAYERFNLHSTPEKFYIEACDDGADDVLVIDRVSTEMTLAGIKDIPPSGITRPICGVMGTVRLVAGMYLIVITRKRKVGDLFGHTVWKAVEFDVISYKKTILHLTDIQMQDNKTFLTMINNVLNTDGFYFCTDYDLTHTQQRLSNTSPDFQEMSLLERADQRFMWNGNLLREIIAQPELHKFAFPVIHGFIVMKPCCINGKVFEWIIISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVQFNNARASFVQTRGSIPFFWSQRPNLKYKPKPLISKDTNHMDGLRRHFESQVLIYGKQVILNLVNQKGSELPLEQAFAKMVSSMENGFIKYIAFDFHKECSKMRWHRLQILVDAVSDMQEEFGYFMVSSDGKVLSEQSGTFRSNCMDCLDRTNVIQSLLARRSLQSQLQRMGVLHVGQKIEEQADFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTHWGLVMDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYSVDETDSLTPLHVKKDWKFLLLPVIMVVAFSMCIICLLMAGDTWTETLAYVLFWGMASALTAAVIVVNGREFVDAPKLVQKEKMD
The following text describes a protein:
Function:
Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MKFVEIRDLQVTYMGKDKPSIVVDKLDIEEGESVLITGRSGSGKSTLVSVINGVIPHLINAEIKGEVRVFGFDVKSTPIHEISKYVGTLLQDPDTQAFNYTIIDEVAFGVENYMISRDEMIERVEESMKIYGISHLRDREINTLSGGELQRTILASVLAMRPKALILDEPTSNIDPQGTREILELVKTFRSEGISLVLVEHKIERVLPFVDRIIVVEEGKIAVDVRKDEIVDKADFLYSLGLEIPDYMLFLKKNGFRKIDYEYLRKTYTYRPPSRIGGKGEALYASVKVKTKNGIYLINTKISLKQGTITALMGKNGSGKTTLLKVIVGLIDKKRLIVEEEKVIVNGVDLSKTKLVERGKFIAYLPQFFDVMFIKRTVEDEIKFSMKNRGTYDEKRLGEVLKMFSLDAYRKEDPLVLSMGQRRRVAMASVLAGGAKVILMDEPTSGQDWYHRQILGKELLELRDKGYTILVVTHDSRFVDRFADYLLVMNEGKIVLEGKPEEVFIKSLRHGIEPPLEYELGGLIKNEHFS
The following text describes a protein:
Function:
Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
Sequence:
MTTVLLSLGSNVQPTHYLRLAVEALRARFGPIDVSPAYRTAAVGFDGPDFVNNGVQLQTDWELQALDDWLHALEDRHGRDRSGPRFSDRTLDVDVVFFGDRIVEGPGHLRVPRPELKHAFVLKPLADIAPAFVDPLSGKTLAALWQAHPQYGSAFTTVELDNAVALPQ
The following text describes a protein:
Function:
Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MGSLERSKKKVQLWKKAVVHFSLCFVMGFFTGFTPTGKASFFSDRVAASNISESTTPQPVEVLHPNPINRSLIAEAPATNIPMSRSAKEFERTEVSSEKEAAKEPKLTTRGLVIIVTPTSTKDQFRGVLLRRLANTIRLVPPPLLWIVVEAQTDSDEVSEILRKTGIMYRHLVFRENFTDTEAEMDHQRNLALKHIDHHKLSGIVHFAGLSNVYDLDFFQQLREIEVFGTWPIALLSANKKKVKIEGPVCDSSQVIGWHLRQMNNESEKTRPSINIHISSFGFNSSILWDPERWGRPSALQKYSQNSMRFVKQVVLEDETKLKGIPPEDCSRIILWSLQFFSGAATIDHDLQTVASDGARK
The following text describes a protein:
Function:
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
Sequence:
MANSGQEHEIHYNLVEDDEFDIVNIVVEGTDGIHSAGAAPSASVGVGIKSPITSQPRIPGHPLSQKWLHEELGKYPAKTHVQKVVEELDAPKSGLIYLRGFDEPLYPYSDQGPPFRQQRHFFYLSGADFPGCAVTYDIPRQELILWIRRNDPRLSLWYGTTPSIDESKSKSDVSDVRYIDGLTAYLHAVLTPENGGGGGPLYVLSPDQLPKLSPSPPQYSFFKGMHGSASRGLKIDTTSLLPAIEAARVIKTPHEISRIRRAVSLTSLAHRMVLQRIKHLTNEREAHAVFEGFCISQGAPHQSYAVIAASGPNASTLHYDANDEPLEGRQTMLLDAGCEWGCYASDVTRTFPLNGKWTKEGEEIYKVVERMQRECIDAIRPGRLYYKLHLVACLIAVEELMKLGILYNGTRSEILARGTVAAFFPHGLGHHVGLEVHDVSGRERLLLTGSTVSSSGVNSQRVPGFQEPRRRMKREQVTPEDLAAMYREAMMDRDDVEQNVVGPPPPYKGRQRLRENMVVTIEPGIYFHRPYIQSFFLSNPDHAKYINTKVLDKYWDIGGVRIEDCILVTKDGYENLTTAPKGKEALKIINAGIPGFGGDGQAGGGSS
The following text describes a protein:
Function:
Involved in mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MGGGDLNMKKSWHPLLMRNQEKVWKDEQAHKEEMKRVEQLRREIEEERQLLELHRLQEAAGGKKRKDRVEWMYAVPNTNGPNRDSSEMEEYLLGRRRLDDLLKDKIEDQNNSLEKTEFIALQNANSLQDTQAKLRLDPLLAIKQQEQKQLQTLMEKRKYSLDSDRKSKERRHRDRHHRSNQDRSRERSDNEQHSSDKREHSRRSYRNDRNNWRERTHNDRYRHRDKYDSGYFKKHYDDDMRFDQGHFQDERDLKKYVRTSRQYSRSPSPDFRTRNHQFHSRDSQPITQRHTDIESRLQKMQDNAKELDESRRKKIELLEKKERDEEQFLEKERRDTARKWDNQGDFIRNMRKEIYSGDSVSLADRVNSSRHNMLRP
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity (By similarity).
Sequence:
MHDIGKITEGFQNNIKKGKRSNKHPHPLYALPIIKNIEFDYLFDIPIEVFAILSHHTQLYNNLYADYQQYKKGTFLIEEIKEFIKNSKEAYESLGFSKFFEFEDLKIEDIPKDAKPLELHRLRRKYWIEANNYIKSLSFDDKIKIKSIFSFMFSILQLCDDFASLNFSEYAKDREGIFDDVLENPEIYVPTLNIDNPISFILKDYEPYKFQKELYNSKNKFVMLFAPCGRGKTEGALLWALNALKNFKRNKIILAMPTQVTSNAMYDRLVKIFGEENVGLFHGKSFIKLRDSKEIEDEDDLEEIRDENFKGNVFFKPITITTIDHVIYSFVHGFSQADFALGNIQNSVIIFDEVHYYEKYTLEHLLTLFDILRRMDIPHLLMSGTLPNFLMNNLEGYELVVDEEGLNYKPFKLKCSENHLIWKEDDEWKVNENIINEIIENYKKGLSQAIILNTVERAREFYKAVRDKVPAILYHSQFAYKDRVKKEDEIFTLEEMRKSQNKPYVIVATQVIEISLDMSVDVMYSELSPPDALGQRAGRLHRKGKDWRENGKEYKLKIFLPYKHLPYSKELIEKTINHIKFYEKPLDYRDIKDFVDNVYKDYNLSIPSDLKLFFDEAILFGRHWTDISTIDEEGRFFKVRDDKFMKIEVVPQVYFDELGENSLRAEYMAKIPAYLILNEMKNEEGLIHFYPYEKRVGRKTRRYLICSFKYTYEIGFDYKEEEEFEDIL
The following text describes a protein:
Function:
Catalyzes the covalent attachment of ubiquitin to other proteins.
Sequence:
MANMAVSRIKREFKEVMRSEEIVQCSIKIELVNDSWTELRGEIAGPPDTPYEGGKFVLEIKVPETYPFNPPKVRFITRIWHPNISSVTGAICLDILKDNWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVAYQFKDKYDLFLLTAKHWTNAYAGGPHTFPDCDSKIQRLRDMGIDEHEARAVLSKENWNLEKATEGLFS
The following text describes a protein:
Function:
Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.
Subcellular Localization:
Secreted.
Sequence:
MRQSHQLPLVGLLLFSFIPSQLCEICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIILALGVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQGAGSYVVRNGENLEVRWSKY
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. SSRP1 binds specifically to double-stranded DNA.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MRRHLPRPCYTVSSYRRAFLSSTMPCSTSEGRPTATVESTSLTGCTPLLASPVPLVNVSLLTKMADNGNAKGGSGAYTINLENFSKRLKVFYDHWKEHKSDLWSSSDAIAIATPPPSDDLRYLKSSALDIWLLGYEFPETIIVFMHKQIHVLCSQKKANLIGTLKKAANESVGVDIVLHVKTKNGDGADLMDHIVQAARNQSKSDKPVVGHIAKEVPEGKLLETWTEKLSGSGVRLTDVTNGFSELFAVKDTTEVTCVKKAAYLTSSVLKNFVVPKLEKVIDEEKKVSHSSLMDDTEKAILDPLKVKVKLKPDNVDICYPPVFQSGGKFDLKPGASSNDEYLYYDSASVIICAIGSKYSSYCSNVARTYLIDATPKQSKAYETLLKAHEAAVQEVKPGNQMSAVYQAAVAVIEKDAPELLPNLTKSAGTGIGLEFRESGLNLNAKNDRKIKQGMVFNVSLGLHNVQAETTSEKTKQFSLLLADTVLVNERGHDILTAPCSKAVKDVAYSFNEDDEDVAEVKMESKTIDVMPTKATLRSDNQEMSKEELRRQHQAELARQKNEETARRLAGVGSGSGDGRGPARASNELVAYKNVNDVPFVRDLVIQVDQKNEAVLLPIYGSMVPFHVSTVKSVTSHQDNRTCTIRIFFNVPGMPFSNDSKLNSQGAIYLKEITFRSKDPRHSSEVVQQIKTLRRQVASRESERAERATLVTQEKLQIGNNRMKMMRLSDVWIRPAFGGRGRKLTGNLEAHFNGFRYSTSRSDERVDIMFGNIKHAFFQPAEKEMITLLHFHLHNHIMVGNKKTKDVQFYVEVMDVVQTLGGSRRSALDPDEIEEEQRERDRKNRINMDFQNFVNKVNDHWSQPQFKGLDLEFDVPLRELGFYGVPYKASAFIIPTSTCLVELIENPFLVVSLSEIEIVNLERVGFGTKNFDMAIVFKDFKKDVLRIDSIPSASLDAIKEWLDTTDLKYYESRLNLNWRPILKTIIDDPQKFIDDGGWEFLNMEASDSETEDTEESDQGYVPSDAEPESESEDDDSDSESLVESDDDDEESDEDSEEEKGKTWEELEREASNADREHGAESDSEEERRRRKAKTFSKSRAPERSSFKGAPPSKKPKFR
The following text describes a protein:
Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Sequence:
MDEKKKSLRKKVERSVFAGNRAAAAKELGSTGDPEAVPILIKALEDSSPKVKIAASDALGRLNDPAAVPGLIKMLAEPESTVKKTAIIALGKIGTPEAVSGIVKGFSDPDKFVQKESVKALMKIGSLEAVSGLTKALGSSDIPLKKTSIIALGKINTYEAGCGLIKALEDPDNRVRQRAVKTLGKRGNPDVLEDLMEALKDSRQPVQEAASEALRKIIAASDSVPVLVKALDATDRNVRKAAIEALWKAGTPEAIPPLLRELDDADWYLRSRAADALADIASPEAALGLIKVMDIHDSPVKKIIVNALGKIGTVEAVEGLVKALEDLDSSVRETAALVLGKTGKTEAVPGLLKALHDSKNAVQEAAVISLGDLKAKDAVPELLKILDDPEAMTHKAVISALEKIGTPEAVSGLARALENHGASVRKAALKALERVEKSGNTLEKVKNLGTSGFEVSE
The following text describes a protein:
Function:
Triggers NCR3-dependent natural killer cell activation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The C-terminal part is similar to retroviral Gag protein. This putative protein seems to be the result of a fusion between an Ig-like domain-containing protein and a ERV.
Sequence:
MTWRAAASTCAALLILLWALTTEGDLKVEMMAGGTQITPLNDNVTIFCNIFYSQPLNITSMGITWFWKSLTFDKEVKVFEFFGDHQEAFRPGAIVSPWRLKSGDASLRLPGIQLEEAGEYRCEVVVTPLKAQGTVQLEVVASPASRLLLDQVGMKENEDKYMCESSGFYPEAINITWEKQTQKFPHPIEISEDVITGPTIKNMDGTFNVTSCLKLNSSQEDPGTVYQCVVRHASLHTPLRSNFTLTAARHSLSETEKTDNFSIHWWPISFIGVGLVLLIVLIPWKKICNKSSSAYTPLKCILKHWNSFDTQTLKKEHLIFFCTRAWPSYQLQDGEAWPPEGSVNINTIQQLDVFCRQEGKWSEVPYVQAFFALRDNPDLCQCCRIDPALLTVTSGKSIDDNSTKSEKQTPREHSDAVPDAPILPVSPIWEPPPATTSTTPVLSSQPPTLLLPLQ
The following text describes a protein:
Function:
Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle. May play a role in embryonic development. May be required for proper cilia beating (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, axon. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to two to four centrioles throughout the cell cycle. Localizes to mitotic spindle microtubules during prometaphase and throughout the remainder of mitosis. Localizes to cytoskeleton on interphase. Localizes at the ciliary transition zone which connects the basal bodies to ciliary microtubules. Colocalizes with polyglutamylated tubulin.
Sequence:
MSPGSGVKSEYMKRYQEPRWEEYGPCYRELLHYRLGRRLLEQAHAPWLWDDWGPAGSSEDSASSESSGAGGPAPRCAPPSPPPPVEPATQEEAERRARGAPEEQDAEAGDAEAEDAEDAALPALPVKDVEDKPEQQTRTRETDKSPTSTEPRQQPSALFARGNRKAVKSPQRSSSKIKENKHPFALYGWGEKQTDTGSQKTHNVCASAPVHEIHESALRAKNRRQVEKRKLVAQRQRAHSVDVEKNRKMKASSSENPWMTEYMRCYSARA
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).
Miscellaneous:
MISCELLANEOUS: Present with 5440 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSSLLSVLKEKSRSLKIRNKPVKMTSQERMIVHRCRFVDFTPATITSLAFSHKSNINKLTPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDDFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSFSNGNYRKMPTVEPYSKNVLVNKEQRLVVSWSESTVKIWTMGTDSSTEQNYKLVCKLTLKDDQNISTCSLSPDGQVLVVGRPSTTKVFHLQPVGNKLKVTKLDNDLLLRTSTKLVKFIDNSKIVICSCEDDVFIVDLESEEDEKPQEVELLEVTSTKSSIKVPYINRINHLEVDQNIAVISRGCGVVDILDLKARISKPLARLNNFITAVHINTSRKSVVVITADNKIYEFNMNLNSEAENEDSESVLTQWSKNNTDNLPKEWKTLKENCVGIFSDIENSSRLWFWGATWISRIDFDVDFPINKRRKQKKRTHEGLTITDESNFMNDEEDDEDDDIDMEISENLNVLLNQGNKIKSTDVQRNEESSGHFFFTDKYKPLLFVDLISSNELAIIERNPLTFHSKQKAFIQPKLVF
The following text describes a protein:
Function:
Functions as a phosphatidylcholine:diacylglycerol cholinephosphotransferase that catalyzes the transfer of the phosphocholine headgroup from phosphatidylcholine (PC) to diacylglycerol, a major reaction for the transfer of 18:1 into phosphatidylcholine for desaturation and also for the reverse transfer of 18:2 and 18:3 into the triacylglycerols synthesis pathway.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSDAVTKTVAPLRRKANPINGKHTNGVTIDGIFDDHNRQIGPINSQMEDIAQKTDDGGGGEWTSKASFMTWTMHDIIYVARHHWIPCLFAAGVMFFTVVEYTFQMTPASSQPFDLGFVATRYLHSILASSPNLNTVLAALNTILVGMQTTYIGCTWAVEGRPRATIAALFMFTCRGILGYSTQLPRPQEFLGSGVDYPVGNVSFFLFYSGHVAGSMIASLDMKRMQRFRLAMVFDILNVLQSIRLLGTRGHYTIDIAVGVGAGILFDSLAGKYEEMSKRHLRNTRCSLISKDSLVT
The following text describes a protein:
Function:
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVRVVVCGALGRMGRRIIELALQDKDVEVVGGVEHPDCVPSIDLGEALGKEELKGKPLTSRLEELLPYTDVVIEFSGNPTAAVGHAELTTLEKKAIVIGTTGFTKQEIEQIKEFSKNAPVLLSPNMSLGVNLLFKLAEIAAKVLKDKNFDAEIMEIHHRFKKDAPSGTAMKLAEILSETLEKKNLVFGRKGEAPRKEDEIGVMALRGGDVVGDHTVYFLGFGERIELTHRATSRDTFAKGAVEAAKWIKGKEPGFYTMFDVLGL
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins.
Sequence:
MSKKLLRKFDSPGTSKTPRAIDKYDFLRLFAVAKDTQSEGKALDHIVIDVEDNIPAKEERSRCEPSGYKTCDLIDVASDDSRGRIGISSSSSSSLSENDDASNGEEATSVTSGSREVDSENSQVLIIPDFIIYGDAYCTNSKLTFSRNCMSVESSSVNATKGTFSCRWAIEDIVRIESQWCSELETAVVNVLLKSRDPNGVDNAKEISGIDLLKFSLYDAKWSKEVETIKLLDSRYKDIWFDTITESEESACSGHNLETSLTNLAGSFENLVYPQGEPDAVVVRKQDIELLKPRRFINDTIIDFYIKYLKSRIPPEERGRFHFFNCFFFRKLANLDKGSPSSFGGREAYQRVQKWTKNVELFEKDYIFIPINFSFHWSLIIICHPGELVSSSVENPSRVPCILHLDSIKGSHKGGLVNIFPSYLREEWKARQGNTTMDLSRASNMQLLSLELPQQENSFDCGLFLLHYLELFVAQAPAKFNPSLITTSGNFLTRKWFPAKEASLKRAYILELLYNLHKGHDPSIIPANSKSKPPHCRVSNENDEENESKNVTEICKWRKPFHGSSAIVPYIPQTKNCSADQILSKEVFYTRGYDLPEASKRRKSFMSPIVEEVQESGEKEEIHLPMDTEESICQEMETLRKGECMLYIEDTDDEDAVVEYVPDSQDSCEVEMKEEDDDELILFTGASKNIHKTREIKSASALIEKGVHKSKSRGLAARSCCNNILLVLSDDEGSSAASDELHNKENFSSSRCNVMAKKPKTIYRR