lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional coactivator necessary for expression of the clock genes PRR5 and TOC1. Antagonizes REV8 function in the regulation of anthocyanin accumulation. Involved in red light input to the clock. Activates clock-controlled genes with afternoon peak. Mediates light inhibition of hypocotyl elongation. Unable to bind to DNA, but recruited to the evening element (EE)-containing region of the PRR5 and TOC1 promoters through its interaction with the DNA binding proteins REV8 and REV4.
Subcellular Localization:
Nucleus.
Sequence:
MFDWEEEELTNMIWGDDAETGDHIVPFKVRSEQLNKKEQIEESKTAEQKITGTKIDLHDKNLGSSSSHNVDEGLPQPDFCMSSWPDTSLTNATKVDQDLSATELSKCLAEPVRYDSTRGGAFLLKQSCFTWVRSFQSNHFKSCVLTLFLPEKTSELGKGPDIFHSSDESKEQGDFDDYSWANIGSFDDLDRMFSDGFAAMMSLYLVMAVSAVVMSYGHLLKITEFEQQENQQFPLTGKANGLSSQSVPSVRVTLKADQYREHKGQPSVEDQPYQQNKMMKFSKMPGTSEARPFQELYGQRIPFSNSAGKCVNQLAPPQSSLMAVNLLSESEGSGTSHYSHMPNQYMANSAFGNLANPYSSVPVISAVQHPDVRNQLMHPSYNPATATSVNMATDASARPSTMTPQEKLEKLRRRQQMQAMLAIQRQQQQFSHQVPVADQSITQNCLQDIPLQLVDKTNLQGLTAMPSFDPSSSLEQDDSGKFAAAVDNSAEFAVLYRLQDVVAKLDMGTRTCIRDSLFRLAGSAAQRHYTSDTSHSNKTSQDDQEVIPREESRYRYAGMPDTEAVTNPTDRTVAHLLFHRPFDMLAAKRMEGPESPASSKMGTEEKGNFPKCSIRETHLTKQKAQKEEGPADSLALGNAPNSGSSSTVGERVVEASQGNKRKL
The following text describes a protein:
Function:
Plays a role in early meiotic events; during prophase I contributes to synaptonemal complex (SC) assembly, synapsis and chiasmata formation and stabilization of homologous chromosomes pairing. Required for restricting SC assembly to bridge paired chromosome axes. Required for the timely progression of meiotic crossover recombination. Required for the synapsis checkpoint.
Subcellular Localization:
Chromosome. Note=Upon entrance into pachytene, localizes continuously at the interface between paired and aligned homologous chromosomes. As nuclei progress through late prophase, chromosomal association is progressively reduced.
Sequence:
MNFEKLVSQAVNGDRFKIFCGQLTEFTNSLAGEREAIEKGMRQIETQQLEAETSFTERIAEDRVKCAAQRESLERQLQDLTATDNKLSEQKRDWEERQEKAYDELMSYLENEDVDSAGTQFGDHFNSLIKSMNNLSHDSMNGQFNSLKNNLDELNIEKKQLEVAIADQSSTISEMIPSLRPTCGATYKERNTLRIIFHYQVAKLRSEYQKCRLQEEALKARLST
The following text describes a protein:
Function:
Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3.
Subcellular Localization:
Nucleus.
Sequence:
MSPGQTTVIQVTNLSAAVTSDQMRTLFSFLGDIEELRLYPPDNAPLAFSSKVCYVKYREPSSVGVAQHLTNTVFIDRALIVVPCAEGKIPEETKALSLLAPAPSLSSLLPGAGLLPIPAPTPTPPIASSLASVLRREKVEVPLLSVPLTSLGVNLPTPLEPVITTLAPVLPALTPAIPAVADLPQPPLMGNVDPTKVDEIRRTIYVGNLNSQTTTAEQLLEFFKQVGDVRFVRMAGDETQPTRFAFVEFSDQNSVTRALTFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPETGKPVEKIKQEHSKTRSRSRSKSRSRRKRSRSKNRSHSRNRSRSRHKERRRSKSPHKKRSKSKDRRKSKSRSRSRDRKKEKEYKSKGREKEKQKDKYDKKRKEKRSRSPSKSSSSIRRSQSASREKRKRRSRSLSKSPRTSKTLKRSSRSPSPRSKNRKEKKKGKERDHNGNRHEREHSGSQKRSKVQERKEAADHYNTKLSEKHHSKDERNNMKEVLSDSDQGNSQHNGDCQVTEESPPQTEEMASSSS
The following text describes a protein:
Function:
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MSQSSPSDPDSPGAQRCPNVTDVTEEELKVCAVCGDRATGYHFHVMSCEGCKGFFRRSILKGVHFTCPFTRSCPITKAKRRQCQACRLQKCLDVGMRKDMIMSEEALGRRRALRLQRRLAQAQPGGLTAEQQELISILIAAHKRTFDSSFSQFQHYQPAVRLCIPGPCSQSPPGPGVPSASLSPQLDCLDEDVLPDVFSILPHFADLSTFMIQQVIKFAKEIPAFRGLPIDDQISLLKGATLGICQIQFNTVFNEETNAWECGQHCFTIKDGALAGFQQIYLEPLLKFHISLKKLRLHEAEYVLLVAMLLFSPDHASVTQRDFIDQLQEKVALTLKSYIDHRHPMPEGRFLYAKLLLLLTELQTLKMENTRQILHIQDLSSMTPLLSEIIS
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MACLRATTAALLLTLVSSAAATTTKFNITEVLNKSPEFLTFNGLLSKTNLAEEINKRQTITVLVVDNSAASGITSLPTDTQKKVLAVHVILDYYDPMKLENIEKGTALLTSLFQTTGAATDSMGFVNYTHSADDQMVFGSAEPGAPLSSQLVKVVACRPYNLSVMQVSAAIIPPSISSSAYGSSSNASVPTITEAETLESPDEASALDDDAPASSPPVHSADTAAGAHTSAGNTVVVRTRVWLVGLVILMV
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MAMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQGADYYGSGAQGADFQPSGLYPRPDFGEQPFGGGGPGPGSALPARGHGQEPSGPGSHYGAPGERCPAPPPAPLPGARACSQPTGPKQPPPGTALKQPAVVYPWMKKVHVNSVNPNYTGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSSSSSSCSSSAAPGQHLQPMAKDHHTDLTTL
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
MTDAMKRLATALEGSPASLEHEGPLQDAHLIAIRDLATSATVTDLRNRLLNGSLCPQGATRLTAALWNETSVRGYQKCLLAARQARLDAGHSFNSYDHLAEAGVAMRSAMCSDGAQPKTCAEWARLIDLYTSFLPDRSHIHELENLPQEIAIGELLRETVERVRRAEDHAGGDGFALDCVVDVGGGNGFLAAQVAERLQCDSVVIDPFFPAHSIDCCPRLWRDTAHRARPATRRQRTLHRTVALFRDVRWSDAVPAAPARTALIAKHLCGSGVDEVLRHLEAQECLPRILVLAPCCFNKITVDRYCDAAYLRQVMGIDSEEALERVNRLTDWNMSCYQSTHERMLARVEAARRSSATSGRGCACEVQIAMEAVASQALPAVDSSSAAASPPCCYQRRSGPRSIANSITCTHDFALLAEALLNYGRMQWLQQRHYDVHLVQYVPDVVTPKNKCWLAIRQAHTS
The following text describes a protein:
Function:
Plays a role in the regulation of membrane potential. Could mediate a proton leak.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDSAKIINIILSLFLPPVAVFLARGWGTDCIVDIILTILAWFPGMLYALYIVLQD
The following text describes a protein:
Function:
Microtubule-associated protein (MAP) that regulates the orientation of interphase cortical microtubules. Binds to, bundles and stabilizes microtubules. Required for the organization and stability of cortical microtubules in hypocotyls. Required for normal hypocotyl cell elongation. Acts as a negative regulator of hypocotyl cell elongation in the light.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Associates with cortical microtubules.
Sequence:
MDICMDKEPDGVVVYANGDSCNPNQENVSEPLLDSVSRDDANVHTELRYGEENIEVNEYDVKECTSEIPVGKPIGDDFESKDVTKSSLHAKHASKSGRGNNKTRNTVPQPFSLATEKRASSTRSFTSESLESAGLKKFPDGHSKVQSQATKVPRKPLQPKNKKLSDEEDSCSVASYATSGAKSAKSRTVVTAAPSFRSTERAEKRKEFYTKLEEKHQAMEAEKTQSEARNKEATEAALRQLRKSLRFKANPMPKFYHEGPPPKVELKKPLPTRAKSPKLGRRNPKEGNRAKGASRRHETRKTLVISKEDHDDETTRNADQINHKEMNRNLEPETAFAC
The following text describes a protein:
Function:
Co-chaperone required during oogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with Hsp83/HSP90 and is required for the biogenesis of all three piRNA major populations (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MEFQIDVDFQNRKTEMFINGDDDLFPEMGDEDDSDGEDTLRNIEETTKKMMLASPDYLSFEELGANMIDCMSTGDVKMLIIEEGKGPLVPVDSEVTIHYAAYWEKAVIPFDSTLTMNMGAPKRLRLGTGKIIPGLEIGLTMVKGPQARLNLLVQPAAAWGPRGVPPRIRPEPALFVIVLYDVKDNYAATRFNDLPMAEQTKYEVTLRTVNALRADAKELYKKKKYVKAIKNYQQAISVLRLSRPGTADEELDIKNNKVNAYLNLAVCYYKTNKPKHVLNMCECLDRLIDTEKHCKALYYYGKAHEMLGKTEMAIKYYKKALKLEPKNKEIGKILADLDTKTKDFAVNEKAMWLKAFNVEVPATNAVYDVDATFQSDVLDMCQSLAGRSEFAKFDLPVGLTKNEVDCIKGIVSDFGCLSVDVSGEGRNKKVCIVKKIV
The following text describes a protein:
Function:
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Sequence:
MEAAEPVLEAKETEERTPQENPSPCLLERHLRSKPLMRQVRIQLTPVQLSSDGEGERKRHLAQKRLLEQFSNSEMCSSDEPTAKKVCDHHALGSQNSEEAAFRGESPGRAPVASEDSSSSDSEDPENVGKDYEDGSPELSAYERKRLKNITENARFFASLKMFETAARLREITTKGRSCERKRVRPPKSEPATACRRSMRLQRVDPTGLPLPEPQAQPEPVEEHPRLPPGLLPMVPADQEQGAERTKGFLEMWAKISQVEPKEEERITCTLESYQSSLRRMVLSRDSVAKVVRDRIYSVAVHPSESKTLVAAGDKWGQIGLWDLECGSEDGIHTFVTHSRPVSCIGFSPSNPAQLFSLSHDGTIRCGDVTRATFEEVN
The following text describes a protein:
Function:
Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation.
Subcellular Localization:
Nucleus.
Domain:
Has a particular type of basic domain which includes a helix-interrupting proline; The C-terminal WRPW motif is a transcriptional repression motif which is necessary for interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
Sequence:
MVTRERAENRDGPKMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAVGYLRERSRVEPPGVPRSPGQDAEALASCYLSGFRECLLRLAAFAHDASPAARSQLFSALHGYRRPKPPRPEAVDPGLPAPRPPLDPASPILGPALHQRPPVHQGPPSPRLAWSPSHCSSRAGDSGAPAPLTGLLPPPPPPYRQDGAPKAPSLPPPAFWRPWP
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Sequence:
MSFQSSLYTAFRSLSLTASKRSFSTTRPAQKLPKVPDYIPPYPYGPNYMFRQSNTGLYGGATIQFGNKISQGRNEGKTRRFWKPNVRRKKLWSEALQQFLFIKVTRKALRTIRKAGGLDQYLLDDRPARIKELGVFGWKLRWQVMQTDKIQEQFKQERKRLGLPEPPSFEEWLKQKEGEVKAQVEEHTNIAELTKPTYNEKNH
The following text describes a protein:
Function:
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the rnf8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor ifnar1; deubiquitination increases ifnar1 activity by enhancing its stability and cell surface expression. Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of nlrp3. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in ifnar1 deubiquitination.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). Interaction with abraxas2 retains brcc3 in the cytoplasm.
Sequence:
MAVSAVHLESDAFLVCMNHALSTEKEEVMGLCIGEVDTNRIVHIHSVIILRRSDKRKDRVEISPEQLSSAATEAERLAEMTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSVQAQKGSEYERIEIPIHVVPHEAIGKVCLESAVELPRILCQEEQDTYRKIHSLTHLDPITKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNRQSVIELQLEKERLTQELATM
The following text describes a protein:
Function:
Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development.
Subcellular Localization:
Cell junction, adherens junction. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MPTVESEATVETKVRVEELLKAHNDLIRERKKLKKKIGKSGEKISLGTLRSNLQKIKETKSDAVSAANTNPEKNMRVTKNKPRDPRSAHSEPDDDVSVEEDKQEKANKIQTALQVTAPQEELETPEKEEDATLQKARTKPQPGGTQEKSEKDEEERENKSVDEEEELMRVYQLQVAEEMAKEIKKKIRKKLKEQLTYFPSDTSLHADKLSGEKRKKKKKKVPILSQSETSTLIISDDPTEGEQKKSLVGTVTSESRQDDEINSVEQNVDNNMQEDTKSKPKKKKKKAKAAPCDRHNLCWFLCPPVGAFCQGPRLDSQLLDAPRIVSDDNEDTDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFMISHPMVKIHVVDENTGQYVKKDDSERPVSSYYEKESVDYILPIMTQPYDFKQLKSRLPEWEEQIIFNENFPYLLRDFDESPKVILFFEILDFLSMDEIRNNSEVQNQECGFRKIAWAFLKLLGANGNVNINSKLRLQLYYPPTKPRSQSNVVEVFEWWSKCPRNRYPSTLYVTVRGLKVPECIKPSYRSMMALQEEKPVYCERHHEPSSVDTEPGLEDSKEVVKWKRLPGQACRIPNKHLFSLNAGERGCFCLAFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLCWSNDDRYILTASSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVKELVVTGCYDSVIRIWKVDMKEDPAILIRQFDTHKSFINSLCFDMEGHHMYSGDCTGVIVVWNTYVKVNDVQHSVRHWSVNKEIKESEFKGIPISYLEVHPNGKRLLIHTKDSTLRIMDLRILAARKFVGAANYREKIHSTLTPCGTFLFAGSEDGVVFVWNPETGEQVAMYSDLPFKSPIRDISYHPLENMVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGSFQIDDYVPTENSSMKMQQVKQRLDSVTEVIRACAAKVNKNLSFTSTSASSQQAKSKQSNMLDAHQILRQFGFTQAGIISTERKPCNHHVDTAPTVVALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGSVGKGQEGYFPANHVASETLYHELPPEVKERSPPLTPKEKAKMEKAFSASQKQSFKFQEFRLGSEYMTHAEMGREQSREDRGHMDTQGMKNEQTGRKVTLIE
The following text describes a protein:
Function:
Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
Sequence:
MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKLQNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNNKMLNEQNCIKGEEKNNDMPLKNDDKDTCHMKKLTEFYKNVDKYKINYENDDDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEKISMDMAA
The following text describes a protein:
Function:
Endolysin that degrades the junction between mycolic acid and peptidoglycans in the host cell wall and participates with the holin protein in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the mycolic acid-rich outer membrane. Cleaves the ester linkage joining the mycolic acid-rich outer membrane to arabinogalactan, releasing free mycolic acids.
Sequence:
MSKPWLFTVHGTGQPDPLGPGLPADTARDVLDIYRWQPIGNYPAAAFPMWPSVEKGVAELILQIELKLDADPYADFAMAGYSQGAIVVGQVLKHHILPPTGRLHRFLHRLKKVIFWGNPMRQKGFAHSDEWIHPVAAPDTLGILEDRLENLEQYGFEVRDYAHDGDMYASIKEDDLHEYEVAIGRIVMKASGFIGGRDSVVAQLIELGQRPITEGIALAGAIIDALTFFARSRMGDKWPHLYNRYPAVEFLRQI
The following text describes a protein:
Function:
Transcriptional repressor of the gmuBACDREFG operon which is involved in the uptake and degradation of glucomannan.
Subcellular Localization:
Cytoplasm.
Sequence:
MNKYEIIANEMRNRIKNNVYPIDQPIPDEVSLAKEFNSSRMTMKRALDNLVAEGLLFRKRGHGTFIIQSAIQDDHVHVVSNEILGLTNLLKDKKIKSKVIQFEVQFPTEEVAAHLSIDQKTPVYYVVRLRIVEGEPYVLEKTYMPTHLIPGINDDVLHDSIYNHITNVLQLKIAGTHRKIRACKSDHIDQQHLGCKQDDPILEVEHVGFLDTGIPFEYSFSRHRHDKFVVTSVNIRR
The following text describes a protein:
Function:
May be a positive transcriptional regulator for lgoD and/or lgoT. Is essential for growth on L-galactonate as the sole carbon source.
Sequence:
MSRSQNLRHNVINQVIDDMARGHIPSPLPSQSALAEMYNISRTTVRHILSHLRECGVLTQVGNDYVIARKPDHDDGFACTTASMSEQNKVFEQAFFTMINQRQLRPGETFSELQLARAAGVSPVVVREYLLKFGRYNLIHSEKRGQWSMKQFDQSYAEQLFELREMLETHSLQHFLNLPDHDPRWLQAKTMLERHRLLRDNIGNSFRMFSQLDRDFHSLLLSAADNIFFDQSLEIISVIFHFHYQWDESDLKQRNIIAVDEHMTILSALICRSDLDATLALRNHLNSAKQSMIRSINENTRYAH
The following text describes a protein:
Function:
May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNGPLTMDCICFEPQWPADELLMKYQYISDFFIALAYFSIPLELIYFVKKSAVFPYRWVLVQFGAFIVLCGATHLINLWTFDVYTPTVAIVMTTAKVLTAAVSCATALMLVHIIPDLLSVKTRELFLKNKAAELDREMGIIRTQEETGRHVRMLTHEIRSTLNRHTILKTTLVELGRTLGLEECALWMPTRSGLELQLSYTLHQQNPVGFTVPIQSPVINQVFSTDRAVKISPNSPVARLRPASGKFILGEVVAVRVPLLHLNNFQIYDWPELSTKRYALMVLMLPSDSARQWHVHELELVEVVADQVAVALSHAAILEESMRARDLLMEQNVALDHARREAETAVRARNSFLAVMNHEMRTPMHSIIALSSLLQETDLTPEQRLMVETILKSSNLLATLINGVLDLSRLEDGSLELDSATFNLHFLFKEVLNLIKPVASVKRLYVTSSLSSDLPEYAVGDEKRLMQIILNIVGNAVKFTNEGSISISAIIAKPDSLRDPRAPDFFPLPGDNNFYMRVQVKDTGIGISQQDTPKLFTKFAESQSTASRNPSGSGLGLAICKRFVNLMEGNIWIESEGVGKGSTAIFYVKLEYPARLNESRLPHMRLQPKLGQTSFPGVKVLVVDDNGVSRTATRGLLVHLGCDVTVVSSGEECLQVITKDHKVVIMDVSLPGTESYNAARLVHDRFPKRHEKPLIITLTSNTDRSAKENLLRVGVDAVVVKPVSVEKMRTALSELLEHKKDVQ
The following text describes a protein:
Function:
Chaperone involved in RuBisCO assembly process.
Subcellular Localization:
Plastid, chloroplast. Note=Associated with the thylakoid membranes.
Sequence:
MESSSSLLHHSYLSYLNPKFGKRPLVSYPLMQSSRKCKQTRICSNKMYVPGFGEASPEAKAAKHLHDFFTYVAVRIVSAQLESYNPEAYMELREFLDTNSVSDGDKFCATLMRRSSRHMNLALRILEVRSAYCKNDFEWDNMKRLAFKNVDDSNTRLMREYVLETSHVETDSDK
The following text describes a protein:
Function:
Binds together with bS18 to 16S ribosomal RNA.
Sequence:
MKKKTGQLYEGAYVFSVTLSEDARRKALEKVTSGITNYGGEVLKIHDQGRKKLAYTIRGAREGYYYFIYFTVAPEAIAELWREYHLNEDLLRFMTLKASAVKEVLEFATLPE
The following text describes a protein:
Function:
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
Subcellular Localization:
Secreted, extracellular space, surface film.
Sequence:
MDDSEVCSLCENVIAAVETYVSSQANQNLIIQELDTVVCASLPSILSFQCKSLVKTYTPIVVNMVLAYFEPSAICTEVKLCPGASTFKITADPQFCSDCKAFLGDIDALLGNTTFQTEVLTQLEGLCAQAGSLEAECKLLIETYGPTLFALILSELDPTTDCTMIGLCPAGSAPVISKMDPELCSECKTFLTDAVSFLSNQTFENEILAQLEGLCKLAGSLQAECLLLVKTYGPAAFAYLEAELDPTTVCTEIGVCPGDSAPFMTLRQAISLPVVQPMATLVAARPIQHKEKSKVADTDCDFCKTIVGLFLPYIENNKTEQEVLNAVSEVCKLFGDTTAERECENYVHTYGSLIFELLLNQMSPDDVCKEIGECTSLMASKPMKHLKELLSKLPTDDTFCTLCKMGVGELETILSSNKTKEEIKQEVEKLLCGNLPSPINTQCLSFMEIYGDVLVQLLIEQLDPSSVCAEVGLCDASKHQLNTRMPPLEAGTECLVCEFMVSKLEDEIKENSTESEIRSVLDKVCYELPPTVRGDCDTLVAEYTERIVEYLLSQFEPKALCTALGLCDAATIAKKIALAKKMEIGDQESCILCEYIMSEIDKLLTENSTEAEIQEVLDKVCAELPSHLTAECKEFVDQYEPALLSFLTQELDPKTFCTTIGECDGAKLKVKKSLGNAECTICEFVIAELDTMLKENATQEEIKTALEEICALMPATVRTECESFVETYESILIKLLTTESPDQICTVIQLCSAGFKALQGTIECDLCQTAVREFMIALQEPSVTKEVVAIVNETCAILPAEYKATCLSYVDQYGDLVTEFIAQFFDPITSCTLLEACPYPDNSPRLPKRMLGQHECTRGPGYWCASMENAKECNMVEHCKRHAWN
The following text describes a protein:
Function:
Sugar N-formyltransferase that catalyzes the conversion of dTDP-4-amino-4,6-dideoxyglucose into dTDP-4-formamido-4,6-dideoxyglucose using N(10)-formyltetrahydrofolate as the carbon source. Plays a role in virulence. Has no activity on dTDP-3-amino-3,6-dideoxyglucose, dTDP-3-amino-3,6-dideoxygalactose, UDP-4-amino-4-deoxyarabinose, and GDP-4-amino-4,6-dideoxymannose.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVAERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKVGVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTAKSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFVRVVLEPEKPAEA
The following text describes a protein:
Function:
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
Sequence:
MLTQEQIMNALKHVEDPELHKSVVELNMVRNIQMNGTEVKLEVVLTIQGCPLKAKIQQDIEESLHAIGASKVEVTFGSMTQEERAALTEKLKRNTRTETGMPSMLRPDSGVRFITVTSGKGGVGKSTVTINLATALARMGKKVGILDADIYGFSIPAMMETNKKPTMIDQTAIPVISHGVKIMSMGFFTEGNNPVMWRGPMLNKWIQNFLANTHWGELDYLLLDLPPGTGDVAIDVAAMIPQAKEIIVTTPHNIASFVASRVGVMAKHTKHEILGIVENMAYYEEQDGSKNYLFGKGGGEMLAEQLQTEVIAKIPFAKREENNGSSVYDEDSLVGEVFTSLAEDIIYRG
The following text describes a protein:
Function:
Involved in arsenical resistance. Thought to form the channel of an arsenite pump.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLLAGAIFILTIVLVIWQPKGLGIGWSAMLGAGLALLTGVVHVSDIPVVWQIVWNATATFIAIIIISLLLDESGFFEWAALHVARWGNGHGRRLFTYIILLGAAVAALFANDGAALILTPIVIAMLLALGFGRGATLAFVMAAGFIADTASLPLIVSNLVNIVSADFFNLGFTEYAAVMVPVNLVAVIATLAMLHLFFRKDIPAVYDLSLLKAPQAAIRDMNTFKTGWLVLALLLIGFFALEPLGVPVSLVAAVGALILLAVAKKGHAINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAGLTHYISALLNRLGEQGLWASTLGTGFLTAFLSSIMNNLPTVLVGALSIEGSTATGLIKEAMIYANVIGSDLGPKITLIGSLATLLWLHVLSQKNMTITWGYYFRVGIIMTLPVLLVTLSALALRLSVSM
The following text describes a protein:
Function:
Glucosaminyl-6'-oxidase involved in the biosynthetic pathway of lividomycin by mediating FAD-dependent dehydrogenation of 6'''-hydroxyparomomycin to paromomycin.
Sequence:
MERLRGPSPLENTTARHPAPLGPAHRDGLEPGTADRVWDVCVIGSGASGAVAADRLVRQGLDVLMVEEGFRLAPHVGLDEAESLSRQALARDGEGNWTDEGWPWTTSNLGGGTVYYGGASFRYRPFDFDPGELVHTDGVDVRWPYTLADLVPYYEVLERRLGVCGGDAPGIHRGSRHSRGPAHQPSPAARVLRAAGESLGYRPFPTPLAINRDPHGGRAACARDSLCVSHLCPTGAKGDVVAVFLAPLAAHPNFALRTGVRALRLEQDRSGEVAAVRCLDRQTGQAHRVRARVYVVACNAIQSAALLLRSRTPYSPDGVGNHSHLVGRGLCMKLSEYLSGTVDADPAVLADPYTNTGPFSTVAFLDHYLDPDCPGGFGGLIYESKRDQRHKLVHDALELRIETILADHPNLDNRVGLSTHLDEDGMPAVVIDYTPDPRDLDRLRYMTGRCERLLRTAGARGIRSRSTGFAQGSSHLHGTCRAGHDPARSVVDAWGRVHSADNVYIVDGSFMPYPGGLNPTLTIQAHALRTSRAIASHLAADRAAHV
The following text describes a protein:
Function:
Inner nuclear envelope protein involved in nuclear fission, which is achieved via local disassembly of nuclear pores within the narrow bridge that links segregating daughter nuclei. Les1 restricts the process of local nuclear envelope breakdown to the bridge midzone to prevent the leakage of material from daughter nuclei during mitosis.
Subcellular Localization:
Nucleus inner membrane. Note=Concentrates at the stalk of each daughter nucleus during anaphase.
Sequence:
MQPRFLLHGALLALGIQLCLSIGKITGHISSIEATAADIHDAPSTTTKYVQRTVYAGREKGKIGGPADSWPQRKLDDFLQNHGVKSLDVPPIETPSQFWRKPLQYVSKVTDKCKSFYEKEKNHASHNAQKLDVWIFNSWTNSELSRWLIKNKYEVPEPGTREQLLETVFQASMGDAISTNDELESWSNNLLLSMLDQKNITVPIGASHDDLIVLARRYYDIEERKSQDKVTNITDSQPAPYMKEIIHLWSDGRLIDFLRERNIPISVLSPRETLLKEAYANRFTPRVMIASNVLDGWSSEDLLDWIWKYNKRGSIFSHVAYNSRHELIHAAKLFYMDVASEWSSSDMASLNDSLYSHPSVSKQSTWTEEELKEELESFGELVPVPFSSTKAFERLLPHLYYYLRGPAFLNRIHYWQTFLGNSLKRAFVLSQ
The following text describes a protein:
Function:
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MHSLSQRANTIVCFGGIVLVGVLLLNVLSRAFFSDHVDVDIKLNEIHRFNTQRNFEYSFISIDLDANLEPLFNWNTKMLFLYVTAEYRTKQNVLSQVVVWDHILTEKSKANIHEKRLSKYPIINQGLGLKNNTIKLTFNYNVVPISGILTRHQVGTSEFKFPTTYMKEAY
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Subcellular Localization:
Nucleus.
Sequence:
MGKQGPCYHCGVTSTPLWRNGPPEKPVLCNACGSRWRTKGSLVNYTPLHSRADGEENKDHQRYQRMKSISVNNKYKETKTLKRKAIQEPVLEFNYGFKKAVVEEDASNRSSSGSAISNSESCAQFSSADGSELTGPSQSNAWDTTVPCKRRTCMGLRPKTSSVEKLTQDLYNILQEQQSSVSSGEEDLLFENEMLSMVSVEIGHGSVLMRNPHSFAREEVSEEASCLSSVENKSSISDAYSSHSVKRAEIGAERGSVSVGQSVKEEQLKRTKSQNGRVHVLGSHGSPLCSIDLKDVFNFDEFIEQFTEEEQKKLMRLLPQIDSVNLPDSLRMMFESAQFKENFSLFQKLIADGVFEMPSSTSEARLEEMRTFKKLALSDFRKSRLVESYNLLKEGDKGSATTTSRSSNPNVHKHIVTIKRRCENQTQLKSESRGLMRSPKSVTKMKASYEGNGSCFSQRSLASVFAQGNCSSDQDLLLLDLPSNGSFPQAELLHQL