lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for correct organization of the actin cytoskeleton and cytokinesis. Also required for apical sorting of prestalk cells, a prerequisite for formation of the tip at the mound stage and subsequent formation of the fruiting body. May be required for cell adhesion.
Subcellular Localization:
Cell surface. Note=Forms a discrete lattice like arrangement at the cell surface.
Sequence:
MKDIEASKKPHTTTVAPPQINFIKNNENIFQPKPISNVTTTTVQPPQIVSPPSPPSPPQTTTIAPPTILPTTKTTTTTTTTTTTTTTVQPPQIVSPPIINNLIIQNNLNTPSLSSTPSPLPNNNNSNENDNDINNLKISKEEYQTQIEIQQQIQRQQILERQQLLQRRNQEQLDLLERHNDYQELINTHQNFVPPNNRFSQQIHVSQLKKQSSQSQLQQQLSSQSLQQIQQKSKQPPPQQQQQQQPPPPPIPLLPQIHQQLKPKQQQEQQQQQEQQQQQTENERINELRRLKRKKEYHNDEYKDDEIYLDNILKGIDIRKLEKLTAVELRKIGKTLGVPMGNNTKGETFQRIKSFIENHKKKKQKYREYQSEKNQQQKSNSKKLVNNSTIYDLPIKDIEHLEQLFWRIFRNIVLFRKIIGNLSRGGFFDQQQQQQQQQQSTMTTTSSSSSPMTSSDDKFFYCYNYIFSKTFKYDQIIHVSWIVDSNYFGLLKYKVSRGDLLVFCNHNTINDGDVNDDEDQNTKYEFCKMFKKIFNSIRSIQDKSFYRDLFTNYSEFIFDRINKRYPIDIYLVGSLAIECNCLVATKLLISEFQFRPVMNHSLQLAIKSGSYKMVKLIVTTIHRQMSLNPNNKPFDIEMFSKINNPSIKIINLLIQLRLFTYSNIINLVIADAKLINDNNENDILQFNKNLKNQIFNYSNLLNSFTFNNNINNNNNNNINNNNNNNNNNNNNNNNNNNNNNSNLSNNTIEYSKIKTKTVFNQFTIKQLINSCKLIVTFDLKNQYQQQYYKRHYEDSDNEEEEEITQASFTINTMAEIEFIETQITKEEKHCFVKKVIQKQLLKDGEKEDYDGIKRLAELYVSLNPHLKVYCNFMYKIIYGNENCYDQDLDDEDLFDYRVTRVFDSNCFKQSLKYGSPGYWIEYKEVEMKYAFLSNKYRNEITPNLLFKYVSPNNLNKQLKFIKKIYNSSIENGNSNGNGNGNGGTVIGGILDRLLLFYLIIENNNLELLSIVIKEFPLISNFCYIAKSNSEIYNLKIPRFIRSIEMLEFCFSNFRDHFYLPQSNSLTADFYGFQNVELLRKYDQLMVLDDMDKGIIVSNKKVRASFDDFHFIFEWGSSLKNYNNYLKMLAYIVEDPYGLYTIVTNEILLLSAILSPTTSSGEPLLNLNIERQLIFQEIISSFSTILEGTELKYYPEQMFQESTHLKRFFDWIFENRSEDLLIGGRCVITQSVQSHMLYRAGRLDIVLRKGYYYDDTNEGSKKIMPVGLALVLDDIGKYGDVVALEKYIRSCIPLMKQQSELLTLLDKDERESRACFSQCQRHFSSLLSKASIYGRINIFQHIFYNHQFIFDKKSLLFARKGFLSKISFKKLILECHYHKQHHILDFIQNVIGLDITPKQIKSN
The following text describes a protein:
Function:
Transcription factor which acts as both an activator and a repressor (By similarity). Activates transcription of a number of genes including the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 which are involved in protection against oxidative stress (By similarity). Required for normal brain development.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the nucleus and cytoplasm with higher levels in the nucleus where it is expressed in a diffuse manner. Located in the cytoplasm of spermatocytes and strongly accumulates at the perinuclear region in elongated spermatids.
Sequence:
MGNECFLTFTTTHLSEAEQKLALYRLQLVEPPKLPLEKKTNPDKDGPDIKPNLWMWVNPNMVYPPGKLEVAVKEEDQSALSAFQPALKEEEDSCSEASEVQQPLPPCRQKRKQRRSTVPLPLAPGRRAPLENPWRLPQAISPEGRLWSRPPLHYFHLIALALRNSPPCGLSVQQIYSFTREHFPFFRTAPEAWKNTVRHNLSFRDSFEKVPASRQGGASTGPRSCLWKLTEEGHRRFSKEARTLASTQLQSIQQCMSQPGVKPFLFDL
The following text describes a protein:
Function:
Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Essential for retrograde trafficking of IFT-1, IFT-B and GPCRs. Negatively modulates the SHH signal transduction.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MATEAALASAQALINYYCQEKYFHHVQMCANEGLKDYGNDPVFLFFRAFGMLMEDEVQESIRELEVIKDKTDISLCSLMALIYAHKKSSHPDREAIQELDTKMKELRKTAGHRALYFAGLFLWHVGRHDKAREYIDRMIKISNGSKEGLVLKAWLDLTCGREAYAKKALKYLEEGLGDGTDVFAMLGKAHYLEMRQNYSGALEVVNRILVNCPGFIPALIKKMKLQLALQDWEQTVETALRLLQKDGHNLEALRMLALHYLCREGNVHEASTKLGDLIRALDQFEPQNAHLFYNMSLAFSRMCERNPLILQQTQILVERAVNMATNDAEIATELGYQFILQGKIREALKWYKTAMSLDETSVSALTGIIRCQLIEGHLQDADQQLEFLMEIQQSIGKSGELSYLRAVLAMKKQKKQEEVIHLLNDVLDTHFSSLHGLPLGIQYFEKLNPDFLLEIVREYLSFCPTQPSAPGQPVSPLLRHCASVLEAIMKTAPGLHQAAFLIAKVKYLSGDIEAAQSSLQHCLDQNPSYADAHLLMSQIYLFQDNLKLCSQSLEICLSYSFEIRDYPLYNLIKAQTQKRMGEVQEAIKTLQIAMSLPGMRRAGTSVKSKGKKPEVSPSDRVSIFLELVDAHRLNGEQHEAAKVLQDAINEFSGTPEELRLMIANAELSLMHGDVEQALSMLRNVSPEQPYFVQAKQKMAEIYLKHRKDKKLFVSCYRDLVDKLPSSHTYLLLGDAYMNIQEPEKAIDVYEQALKKNPKDGTLAIKIGKALIKTHNYSKVFVLKGGSASSTVLWCGPAIVLRLYLSVVNSQEQINRKISTIHSTPYFSRECLLLAPYVCFCSQTVNELSSLVDDSRYHVLLAKIYSKMEKIDQSIVSLQRARELQARVLKRTQMEQPDAVPAQKALAAEICAEIAKHSTVQRDYEKAIKFYKEALVYCETDNRVMLELAHLYLAQDDTESCQQQCALLLKIDQDNEAATMMMADLMFRKQDYEQAVFHFQQLLERKPDNYATLSRLIDLLRRAGKLEEIPKFLELAEKNSSRAKLEPGFHYCKGLYLWYTGDPNDALRHFNKARKDSDWGQNAIYNMIEICLNPDNETVGGEVFDNLDGDVGNSTEKQESVQLAVRTAEKLLKELKPQTLQGHIQLRIMENYCLMATKQKANVERALNTFTEVATAEKDHIPAVLGMATAYMILKQTPKARNQLKRISKMNWNPIDAEEFEKGWLLLADIYIQSGKYDMAGELLKRCLRHNRACCKAYEYTGYIMEKEQAYKDAASNYEMAWKYGNQTSPTVGYKLAFNYLKAKRYVDAIDVCHKVLELHPNYPKIRKDILDKSRAALRA
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MNRHAFVEMTPLRPEPTDGSPTRGSQPAAVGQPQFFSRRDDMSYIWGTGIAVEVFRAEFQRFLETFEMPQDVGAAPGADAGAHRGGTRNFFLQELLRLRLQRRSLFEMDLQLFCRAAPRLYQQLIAHPVECLQMMESVAEEVSGRLVAAAGTHPSMPGEDEFILRIAPRNHPEITTLRGLSTRQLEQLVSLQGMVVRVSKIIPEIRVALFQCWSCNHTRHSVVDRGRIFEPTRCDSCGKQYSYRINHNLSVFEDKQLVRLQEAPEHLADGDTPVTMSVVVYGDFVDSIVPGDRVVVTGIYRAWPVRLNSNTRIIRSIFSTHVDAVHIEHRRAGRNAWADQQRQSAGEDEGLPEDPAVVARHNMFRHIAARPDIYDVILNSFARTIWGNEDVKRGILLQLFGGTRKELKCGSFRSEINIILCGDPGVAKSQLLTQVHEIAPRGVYTSGKGSSSAGLTAFVVQNNETGELVLEPGALVLSDRGLCCIDEFDKMNEATRSVLHEVMEQQTLSIAKAGIIAQLNARTSVLAAANPKESQWNVNLNVVENLQIEPTLLSRFDLIFLLMDRHDPAEDRRLASHVLSLFMETDESRASGNAAVPTDDDDDDVDNANGGGTSASRGHLATSRAPILLQHDGEVYLEGTEEKPYMPARVLSQYIAFARENIHPRLTGASHKQLAASYVEMRRARGSTRTVSATLRQLESMIRLAEARSKMRLGDTVSVEDVREAKWLISAALKEAATDPRTGRINLDVFNAPDPTRQTVEGSMLRLEKLIEQRYISAGHTTATVSELRLALNESFGSSMRPLSIVQFMELLALMVGGDHVKSFTASTVSFAGRLS
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKF
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Sequence:
MEDKKMEVDRETHVITSDPTPPPTAPSPTKNSSSPSIAVFHDCPRECPQEDHVKVGGEAQQDIDDTKSDSSEPEYFDIHDDDMTSPIEALSDYGPGGFHPVHLGDTLGPISDPSRFRVLHKLGHGGFGTVWLCRDTQDGKPKALKILSADASEKAAKACPDFKALQLLTHSVSHEEGLSQCFPHALRAHETAQDLLRKYHIALPYEHFWLPYQPNGSHLCLIAPFLGPNLESFCATYGHVTDLVKHVCFQLVEAMHFLHQKGLCHGDFRPANILFCLNEEVERMGDEELVDALGGVQMAKLTRTPLDKNNKDGAKEEEKEWPKELPRYLVGQADMFKLIRGGWCSPSVAVIDFGVSYPVTEPTGKGTGIPLGYAPPEEAITGKNQEGKEKTLVKLGPKSDVWSLGVTLAELVLDYFPFADSSDKLYGVKNMELVMGPIPEPFRSEFREWYKGIWGPDGTALQDVVMVTDPETGKSVLSPLSFSIKRWKEEKEYAKKESGYEDPIRSRMSLGLETLHTKRSGAAIEAQWARDKTKLPSYTWEQTEEEDEMDDDQFPTKKFDDIEVFSDLLRSIFKWMPEDRVSTAEIMAHPWFKDRYAPSKDTKREGVVSRLSQGTFGIINFMVGFPFKAGNFFFRVFSRVFGNFANPLWFL
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mS38 is also involved in the splicing of the COX1 mRNA.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLRRGALSTILKGLNGLSLRSPIPIWHVSASPEVGSKYNLPTVPTTSHVSYRQIAKANFFAGYRPLSANQICVPKVESKTQVSQSQDEEDQPQEYVLSLEDGYLYAQSFSASGSVTQTQPARISTQVWEQICDKLISITPLDLTSVKRKRKLKMNKHKFKKRLRRQRALRKRLGK
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Domain:
Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence:
MDPNCSCSTGSTCTCSSSCGCKDCKCTSCKKSCCSCCPVGCSKCAQGCVCKGASDKCTCCA
The following text describes a protein:
Function:
Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSNLHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVESLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPWEKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPKSHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVSSKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC
The following text describes a protein:
Function:
Involved in the production of blood-red nectar containing the alkaloid nesocodin and that serves as a visual attractant for pollinator visitation, including vertebrates such as Phelsuma geckos. The nectar is initially acidic and pale yellow, but slowly becomes alkaline before turning into red within 24 hours. Together with NEC1 and NEC3, facilitates the condensation of sinapaldehyde ((E)-3,5-dimethoxy-4-hydroxycinnamaldehyde) and proline to form nesocodin, a pigment with a stable imine bond. Protects nesocodin from degradation by hydrogen peroxide H(2)O(2) by catalyzing the degradation of H(2)O(2) into water H(2)O and dioxygene O(2).
Sequence:
MAFLSNMAMFITMLMFSSMMHPCFSQPSCAPMDTMDTNGVDEADIDMMQFPINLEFLEAEFFLWGALGHGLDVVAPQLAMGGPPPYGAQKANLDPLTQNIITEFAYQEVGHLRALERTVGGFPRPLLNLSASNFANLIEAAFGYHLVPPFNPYRDGLSYMLASYAVPYMGLVGYVGTNPNLKGHQTKRLLAGLLGVESGQDAVIRMYLYERQGHVVAPYRHTVAEFTARISELRNRLAMCGVKDEGVIVPRQLGAENQTMSNVLSANYDSISYRRTPGEILRVVYSTGNESVPGGFYPNGGNGRIARRFLV
The following text describes a protein:
Function:
Acts as a co-chaperone and mediates the association of the chaperones HSP70 and HSP90 probably facilitating substrate transfer from HSP70 to HSP90. Stimulates HSP70 ATPase activity and, in contrast, inhibits HSP90 ATPase activity.
Subcellular Localization:
Cytoplasm.
Domain:
The TPR repeats form 3 domains; the TPR 1 domain is composed of TPR 1, 2 and 3 repeats, the TPR2A domain of TPR 4, 5 and 6 repeats and TPR2B domain of TPR 7, 8 and 9 repeats.
Sequence:
MVNKEEAQRLKELGNKCFQEGKYEEAVKYFSDAITNDPLDHVLYSNLSGAFASLGRFYEALESANKCISIKKDWPKGYIRKGCAEHGLRQLSNAEKTYLEGLKIDPNNKSLQDALSKVRNENMLENAQLIAHLNNIIENDPQLKSYKEENSNYPHELLNTIKSINSNPMNIRIILSTCHPKISEGVEKFFGFKFTGEGNDAEERQRQQREEEERRKKKEEEERKKKEEEEMKKQNRTPEQIQGDEHKLKGNEFYKQKKFDEALKEYEEAIQINPNDIMYHYNKAAVHIEMKNYDKAVETCLYAIENRYNFKAEFIQVAKLYNRLAISYINMKKYDLAIEAYRKSLVEDNNRATRNALKELERRKEKEEKEAYIDPDKAEEHKNKGNEYFKNNDFPNAKKEYDEAIRRNPNDAKLYSNRAAALTKLIEYPSALEDVMKAIELDPTFVKAYSRKGNLHFFMKDYYKALQAYNKGLELDPNNKECLEGYQRCAFKIDEMSKSEKVDEEQFKKSMADPEIQQIISDPQFQIILQKLNENPNSISEYIKDPKIFNGLQKLIAAGILKVR
The following text describes a protein:
Function:
Monofunctional pyrimidine deaminase involved in the riboflavin biosynthesis pathway. Also has a reductase domain that lacks catalytically essential substrate-binding residues.
Sequence:
MQAAVGFSVSVSVSVCCNSKCSINASSPHPPLFIPIPSNFNSAFSKPLIIHTHSPKSNSYVVRAQNNHHQDNDDGFYMRKSVELARKGLGYTSPNPLVGCVIVKHGNIVGQGFHPKPGQPHAEVFALRDAGDLSENATAYVSLEPCNHFGRTPPCTEALIKAKIKKVVIGMVDPNPIVASKGVDRLRDAGIEVVVGVEEELCKSLNEAYIHHMLTGKPLLTLRYSLSVNGNLLDSLGNGVTDSGGYYSRLLQEYDAVILSSSLFRENLSANPVPTSKEPGANQPIRIIMHKDSGSSNPIPLVINEVTDKAIIFTNCRTATTPEEAQQGIEIVSMDQINLDVILDYCNRQGLCSVLLDVRGNFSEYEDLVKEGIKKKYINKFVTEVLPVWNGCTKNDPLLPLKNLDQGVKVENLRPMASAQSVVIEGYLNFE
The following text describes a protein:
Function:
Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates.
Subcellular Localization:
Cytoplasm. Nucleus. Extracellular vesicle.
Sequence:
MRLVHLDLKGAPPKVCYLSEIFPLFRALGANGILIEYEDMFPYEGHLRLLRAKHAYSPSEIKEILHLATLNELEVIPLVQTFGHMEFVLKHEALAHLREVARFPNTLNPHKEESLALVTAMIDQVMELHPGARWFHVGCDEVYYLGEGETSRQWLQQEPNSKAKLCLSHMEAVASHMRARYPTTTPLMWDDMLRDIPEDQLSGSRVPQLVEPVLWDYGADLDLHGKALLVEKYRKSGFSWLWAASAFKGATGVNQSLTPIEHHLRNHLQWLQVAGSVPADTLRGIILTGWQRYDHFSVLCELLPVGIPSLAVCLQALLHGDFAENVKARVENFLGISSLEEMSFRR
The following text describes a protein:
Function:
Catalytic subunit of the ethanolamine phosphate transferase 3 complex that transfers an ethanolamine phosphate (EtNP) from a phosphatidylethanolamine (PE) to the 6-OH position of the third alpha-1,2-linked mannose of an alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-2-PEtn-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol (also termed H6) intermediate to generate a 6-PEtn-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-2-PEtn-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol (also termed H7) and participates in the tenth step of the glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MQKASVLLFLAWVCFLFYAGIALFTSGFLLTRLELTNHSSCQEPPGPGSLPWGSQGKPGACWMASRFSRVVLVLIDALRFDFAQPQHSHVPREPPVSLPFLGKLSSLQRILEIQPHHARLYRSQVDPPTTTMQRLKALTTGSLPTFIDAGSNFASHAIVEDNLIKQLTSAGRRVVFMGDDTWKDLFPGAFSKAFFFPSFNVRDLDTVDNGILEHLYPTMDSGEWDVLIAHFLGVDHCGHKHGPHHPEMAKKLSQMDQVIQGLVERLENDTLLVVAGDHGMTTNGDHGGDSELEVSAALFLYSPTAVFPSTPPEEPEVIPQVSLVPTLALLLGLPIPFGNIGEVMAELFSGGEDSQPHSSALAQASALHLNAQQVSRFLHTYSAATQDLQAKELHQLQNLFSKASADYQWLLQSPKGAEATLPTVIAELQQFLRGARAMCIESWARFSLVRMAGGTALLAASCFICLLASQWAISPGFPFCPLLLTPVAWGLVGAIAYAGLLGTIELKLDLVLLGAVAAVSSFLPFLWKAWAGWGSKRPLATLFPIPGPVLLLLLFRLAVFFSDSFVVAEARATPFLLGSFILLLVVQLHWEGQLLPPKLLTMPRLGTSATTNPPRHNGAYALRLGIGLLLCTRLAGLFHRCPEETPVCHSSPWLSPLASMVGGRAKNLWYGACVAALVALLAAVRLWLRRYGNLKSPEPPMLFVRWGLPLMALGTAAYWALASGADEAPPRLRVLVSGASMVLPRAVAGLAASGLALLLWKPVTVLVKAGAGAPRTRTVLTPFSGPPTSQADLDYVVPQIYRHMQEEFRGRLERTKSQGPLTVAAYQLGSVYSAAMVTALTLLAFPLLLLHAERISLVFLLLFLQSFLLLHLLAAGIPVTTPGPFTVPWQAVSAWALMATQTFYSTGHQPVFPAIHWHAAFVGFPEGHGSCTWLPALLVGANTFASHLLFAVGCPLLLLWPFLCESQGLRKRQQPPGNEADARVRPEEEEEPLMEMRLRDAPQHFYAALLQLGLKYLFILGIQILACALAASILRRHLMVWKVFAPKFIFEAVGFIVSSVGLLLGIALVMRVDGAVSSWFRQLFLAQQR
The following text describes a protein:
Function:
Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (By similarity).
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MHLLLAAGFGLLLLLLPPPAASKKPTQCQRCRTLVDKFNQGMANTARKNFGGGNTAWEEKTLSKYEFSEIRLLEIMEGLCDSSDFECNQLLEQQEEQLEAWWQSLKKDYPNLFEWFCVRTLKACCLPGTYGPDCKECQGGSERPCSGNGYCSGDGSRQGDGSCQCHAGYKGPLCIDCMDGYFSLQRNETHSICLACDESCKTCSGPSNKDCVQCEVGWARVEDACVDVDECAAETPPCSEAQYCENVNGSYICEECDSTCVGCTGKGPANCKECIAGYTKQSGQCADIDECSLEEKACKRRNENCYNVPGSFVCVCPDGFEETEDACVQTAQSEVTEENPTQPLSHEDL
The following text describes a protein:
Function:
Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis. Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture. Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with promoter and enhancer regions.
Sequence:
MRVKPQGLVVTSSAVCSSPDYLREPKYYPGGPPTPRPLLPTRPPASPPDKAFSTHAFSENPRPPPRRDPSTRRPPVLAKGDDPLPPRAARPVSQARCPTPVGDGSSSRRCWDNGRVNLRPVVQLIDIMKDLTRLSQDLQHSGVHLDCGGLRLSRPPAPPPGDLQYSFFSSPSLANSIRSPEERATPHAKSERPSHPLYEPEPEPRDSPQPGQGHSPGATAAATGLPPEPEPDSTDYSELADADILSELASLTCPEAQLLEAQALEPPSPEPEPQLLDPQPRFLDPQALEPLGEALELPPLQPLADPLGLPGLALQALDTLPDSLESQLLDPQALDPLPKLLDVPGRRLEPQQPLGHCPLAEPLRLDLCSPHGPPGPEGHPKYALRRTDRPKILCRRRKAGRGRKADAGPEGRLLPLPMPTGLVAALAEPPPPPPPPPPALPGPGPVSVPELKPESSQTPVVSTRKGKCRGVRRMVVKMAKIPVSLGRRNKTTYKVSSLSSSLSVEGKELGLRVSAEPTPLLKMKNNGRNVVVVFPPGEMPIILKRKRGRPPKNLLLGPGKPKEPAVVAAEAATVAAATMAMPEVKKRRRRKQKLASPQPSYAADANDSKAEYSDVLAKLAFLNRQSQCAGRCSPPRCWTPSEPESVHQAPDTQSISHFLHRVQGFRRRGGKAGGFGGRGGGHAAKSARCSFSDFFEGIGKKKKVVAVAAAGVGGPGLTELGHPRKRGRGEVDAVTGKPKRKRRSRKNGTLFPEQVPSGPGFGEAGAEWAGDKGGGWAPHHGHPGGQAGRNCGFQGTEARAFASTGLESGASGRGSYYSTGAPSGQTELSQERQNLFTGYFRSLLDSDDSSDLLDFALSASRPESRKASGTYAGPPTSALPAQRGLATFPSRGAKASPVAVGSSGAGADPSFQPVLSARQTFPPGRAASYGLTPAASDCRAAETFPKLVPPPSAMARSPTTHPPANTYLPQYGGYGAGQSVFAPTKPFTGQDCANSKDCSFAYGSGNSLPASPSSAHSAGYAPPPTGGPCLPPSKASFFSSSEGAPFSGSAPTPLRCDSRASTVSPGGYMVPKGTTASATSAASAASSSSSSFQPSPENCRQFAGASQWPFRQGYGGLDWASEAFSQLYNPSFDCHVSEPNVILDISNYTPQKVKQQTAVSETFSESSSDSTQFNQPVGGGGFRRANSEASSSEGQSSLSSLEKLMMDWNEASSAPGYNWNQSVLFQSSSKPGRGRRKKVDLFEASHLGFPTSASAAASGYPSKRSTGPRQPRGGRGGGACSAKKERGGAAAKAKFIPKPQPVNPLFQDSPDLGLDYYSGDSSMSPLPSQSRAFGVGERDPCDFIGPYSMNPSTPSDGTFGQGFHCDSPSLGAPELDGKHFPPLAHPPTVFDAGLQKAYSPTCSPTLGFKEELRPPPTKLAACEPLKHGLQGASLGHAAAAQAHLSCRDLPLGQPHYDSPSCKGTAYWYPPGSAARSPPYEGKVGTGLLADFLGRTEAACLSAPHLASPPATPKADKEPLEMARPPGPPRGPAAAAAGYGCPLLSDLTLSPVPRDSLLPLQDTAYRYPGFMPQAHPGLGGGPKSGFLGPMAEPHPEDTFTVTSL
The following text describes a protein:
Function:
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAAYTRPMSSCFSRGRNLFNKCPYKELSFVTRRNNATFSHAAKNRSVLLGVGALAGISFGVLYSLKTQSRIAREIEQENYSSENSASNEASHQPKITLYQYQTCPFCCKVRAYLEYFGIDYTKVEVNPLTRKEIEFSTEYRKVPIAIVDGKQARASNDEDHYLLNPFGLLYNEVTASSLVKVDFAGNIVDGGSTNLGVNRAGLVLHSAVHSARKDIACVIHIHQPACVA
The following text describes a protein:
Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMDVNSSGRPDLYGHLRSFFLPEVGRGLPDLSPDGAGPVAGSWAPHLLHGVVEVTASPGPTRDTPRDNTSGCWEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDGKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRPEEPDSVISLNGMVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTMCWLPFFLLSTARPFICGIACSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPELVLMKEAETSP
The following text describes a protein:
Function:
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.
Sequence:
MINMGDSHMDTSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKKKEEVPEFTKIQTLTSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIENALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASETSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELVQFHRDGALTQLNVAFSREQSHKVYVQHLLKRDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHTQAVDYIKKLMTKGRYSLDVWS
The following text describes a protein:
Function:
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MIFLNIISISIRLLLILTLITGILYPIVTTGFAERFFPFRSSGSRVVIQGKIVGSELIAQKFIKDEYFWPRPSAMDYAAGASNASVTNVFLKAKVEERKKFLLEKHSEQTQVPPDLLFASGSGLDPHISPDSALFQINRVAKSRKLTEGQILRLKNIVEESVEKGYIGENRINVLLLNLKLDSEFGIILK
The following text describes a protein:
Function:
Dynein-attachment factor required for cilia motility.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm.
Sequence:
MSSNKSAINADGTTINLSHLEREIQQDIGIYHKHAAEDGMKKRAVHTSKDYDEFRNFVSVSQLKPTSGREVSSLFSGVSGVVTKGGGGGNSVCRNRVGDAVLGGFDDSVQRRKNETDPTVKVATRADDAKLNDGLNSMTFDARQHSSNSATATKQTKLSSREVYDFLREWKQQCKDPTQTLSFLTKTVASTSSEDLPTIQLVLSPGETCKQYFRSEIDSQVVGDIVGALRLLLTQLNDAKSQHGDVGCTDVSCIEDIKSTGSTVTSFIEAWLGSLTGCGRFDLSIAFLTKEEQRQLKEVCTFVRDSGEENISGREYLMRCEKLLK