lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Histone reader involved in homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. Specifically recognizes and binds histone H3.1.
Subcellular Localization:
Nucleus, nucleoplasm. Chromosome.
Sequence:
MEEKRYLKRKEKARSDGNRDQVAVSCNQLGDFYNQQGKYTDAVREYVQEAQIYASMGKELETAKAKRMVGEMYTLLCDYDAAKDHINDYLKIAKRLKNQVEEQRAYATLGRVHLLHGQSLADSSASGSMEQLKLAEKNFLRSLLLIKDLSGQISKLEQLDMQARCYLNIGVVKEHMEAFQESIEYIDKAIKISKTHELWDLTHLCYISMSLLYICKKNDATAALRFCNMALEVAKRFPNKVKKICETLITKAEILIKAGDFASAKQILTKAYKKNTPDENDRVNIEKQLRIVVKVCQTLDELVLTSSVDYAKLKGLYEKLGDGCCHLMNYEKALTYYQKMLENAELNQESGKSLVPIYVSLYQTYRDNGQFDKALEYLWKEFELNQDAPSEAFTTLCTIAEICEQQSHPFWTVHDVYQKALRQADKAGSCSDKLVKIAMVRLRRLMLKHNMQVLVENLEADATAKGIDLDQEESVGDDEEESDGGGTAVQQNTPDWDDDFDLATLTDSDASDLDETEKPRPQRTTRGNRTLVIKKNNKGETQLHQACISGNLELVRRLIDQGHTVNVRDHAGWLPLHEACNHGYREIVELLLDKGAASAINDKGGTSCDGITPLFDACSNGFLDVAELLLDRGADATVRTDYNETCIAGLDKWRQGAQLVDGEQAQYAQLRERLLRTLSKVGICSDKNARPLTNFNAKRISREERGSMSEEEDEEEALHESNRRSLSHNRSGSEYGAKKSKSSTQPSASKEYRSVMAHLKRPNRLNDDPPSTSTLNKHKRNAFLSEDEVDADNWLIDDVGPERKRKRINSGDLSRRTSKENFQDTALSLPANWEDDLLQATPENEYSQRQKQMRKLTLSRSSSMSSNHSSSATSSRKKHQATLLDSGFSRFRSESPLGSESSQDGTTSLISVRTIEPDSTTSTIQVLISPAKSSPIKVQATPVLATTVSFKVKIQDELLLVPIERKKLQDINIRWLAEEAGRRYNKLTGLTPLLRLKTADGFAYEETDPVSVALEQNMLMASILDWKISPLSQRYEEMCLQMQKTVDNKVKLLLERSQNNNMLELSGLWMRAEKTEPIFKALLHQARLTVLDLSCNFIGNEGCQQLAKSLPTLLQLKALRLQCNAIGSHGLEALLCGQGMDKLELLEELNLNQNPLGNASVRILSKYCASPAGQALTCLQLAQCELTELQDFDLGFNKLTRFDISFNQLTQQSVRRLTDQLNSCRLEQLNLSYVRWPLDDASGFALSERLVTLFEGGTCERFVGVQLAGCGLNDAHMYNISQHLAKAKQLQMLDISDNSNLSGTTLGYILDELPQLRDLLAVNCTNLLDDIRLQKLEQLKQLPRRLELTVDEQVFSMPGALETLQSIWQLQFGDKAKMLTTSNSRKIGRRYKGLLKLLADGSDAE
The following text describes a protein:
Function:
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MFQKPFRVKSKTVIRGSDRRKLRADVGKALPSLTEDQLQELVPTKEDMSTMKIYTHSGRNVTVYCLGNNPVFFEMDKNVFPTVYSLWRVPDMLPCLTTWPDVLKNLCGGADLMLPGVIPGEEGLPVIEKNSLCAVSLLGNRAPIAVGRTTMSSSQMQECGMKGKGVTVLHTYLDQLWEHGDQTPLPTMATQQSCPEGHVPDLDSGDATSEEQLQGQLAAEASSTTDTVPIEKLVLNDDLGDEGDLEKVNDLDTETTVGGVKDDGNECGEEEGETRDEEDEVSPVDQMDSLLYQCFLHALKTNVKKIDLPLLTSKLLRGHMQICCPTEKSLDLKKSSYKKLSKFLQAMQTQGLIQVKELSKGVESVVEVNRGHEELKSFEVPDVELPAVEVNDPGTGAGPTYQPPEVVEMFSVTGNLAPLFRTAGIRKGHALSGQEVREFLTQYVKENELVDPNNKRFIVVDPLLCDALRQKGENLTHLTWEDLFTRCCDKMSPCAQLIFPGQPPVLKKGKLEPVDVQVQQRSGNKKVTLIYNLEGFGIRPDTFAHLLQLRVQASTAVNPAPNRKAGVQVMVQGNQVQTVAKLLIDEMKLPKKFVQGVEKAAKKKR
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). INTS15 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters. Within the integrator complex, INTS15 is required to bridge different integrator modules.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates to RNA polymerase II (Pol II) during active transcription.
Sequence:
MSDIRHSLLRRDALSAAKEVLYHLDIYFSSQLQSAPLPIVDKGSVELLEEFVFQVPKERGAQPKRLNSLQELQLLEIMCSYFQEQSKDSVRQIIFSSLFSPQGNKADDSRMSLLGKLVSMAVAVCRIPVLECAASWLQRTPVVYCVRLARVLVEDYCCLVPGSVQTLKQIFSASPRFCCQFITSVTALYDLSSDDLIPPLDLLEMIVSWIFEDPRLILITFLNTPIAANLPIGFLELTPLIGLIRWCVKAPLAYKRKKPCLSNGHISHKVAKDSGASTDRDSHLLYSKLHLSVLQVLMTLQLHLTEKNLYGRLGLILFDHMVPLVEEINRLADELNPLNASQEIELALDRLAQALQVAMTSGALLCTRDDLRTLCSRLPHNNLLQLVISGPVQQSPHTALPPGFYPHIHTPPLAYGAVPAHPAAHPALPTHPGHTFISGVTFPFRPIR
The following text describes a protein:
Function:
Aminopeptidase which cleaves preproteins, imported into the mitochondrion, to their mature size. Could cleave both preproteins and preprotein intermediates already cleaved by the mitochondrial processing peptidase (MPP).
Subcellular Localization:
Mitochondrion.
Sequence:
MWKLTRRLQPHINSTRWLVRNFRNGGAGDATGLYGFDHLKTAKGFQRFVADAIERSGELVSYISGMPSSPEIIKAMDEISDTVCCVVDSAELCRQTHPDREFVEEANKAAIEMNDYLHHLNTNHTLYAAVKKAEQDSNLLTKEASRTAHHLRMDFERGGIHLDPEKLDKVNNLTTNIFQLCREFSENIADDPGHVDIFPGSRIPRHLHHLLNPTYRSTSGGSRGSTRSAHKSKQKGFRINTDPRTVSSILQWTSDEEVRKMVYIQGNSVPHANHGVLEKLIAARHELSQMMGCNSYADIMVEPNLAKSPKVVTSFLQELSKTVKPKADEEFIAIRDFKREKCGNPSAELEPWDETYYTSMMKSSINDVDTAVVASYFPLPQCIEGLKVLVESLFGATFHTIPLAPGESWHPNVVKLSLHHPDEGDLGYLYLDLYSRKGKYPGCASFAIRGGRKISETEYQLPVIALVCNFSRACDSSIVKLNHSEVEVLFHEFGHALHSLLSRTDYQHFSGTRVALDLAEMPSNLFEYYAWDYRLLKRFARHYSTGETIPEKLVNSLQGARNMFAATEMQRQVFYALIDQMLFGEQPETARDVSHLVAELKRQHTSWNHVEGTHWYIRFSHLLNYGAGYYSYLYAKCFASTIWQSICEEDPLSLNTGTLLREKFFKHGGAKDPAELLTDLAGKEIISVHGEGIVPATTYLLNELRL
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
LLVRDHLLGWLDKSTDLKANFNKSAGFSLSKIALWSSLGRNSGLHRELWLACSGPLVIVPSSGDMVFYYPQGHIEQIEACMNEDGLMPMPAYNVPYKILCRVVSVRLQAEANTDEVFAEITLLPHLGTREPILAERSPLFSRAKTDVHTYSKKLTPSDVNTHGGLSIPKQLADECFPPLNNDQDFPAQDLVAKDLNGLEWKFRHVYRGQSRRHLIRNGWSRFVSAKKLVAGDTLIFVRGKNYELYVAVRRAKKQQTSSSTSILSSHYMQHGMLSNAYHAVSSGTMFTIYYRPWTCPAAFIIPYNQYMKASEIDYEVGMTFNMPFESHELDCGRTVCPIFSGTIVDVKDFDPIRWPGSDWRCLKVKWNHAKLMPVRPERVSPWSIVAIGITKRKRRSFSSYPSKAQPLDPANPFGVKDCLMKSSVEHSPPWNSRVLQGQEKAVNAYEENAFRRPHDLRQPPQRKLRWRRGQVRLENQQHNHILDPWLDFIGKEVHGTSPSSNGFSNLQSSKIPSFASESLSIPKIVDYRNSNSKGNVESDVMGSQPTGGSKLKLFGVDILNGPESPSQHGSKLTHFGSFPAASKTVNFLEQSKSTSGNSDTQCSRSCTKVLKYGCALGRSIDMSRVKGYGELISELDKLFGFEGSLLDGSKDWHVTYQDREGNTKLLGDYPWSDFQAMVRKMFICPIGADYLADRSF
The following text describes a protein:
Function:
Through the production of cAMP, activates cAMP-dependent protein kinases (PKAs), triggering terminal differential and the production of spores.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTNNRLKNRKKPNQIHTISEEEEEEEPLFNNEDLQTQHLNSPSSDSISTSSSSSLSSVGGSVVGNNNSNSNGIDNNNSNNNNNNNNNNNNNNNNNNSNNNNNYTGNSIGGNDFKNKASSSSSTPTTSTGIGSSKFPNIKRKNSFSNRYDSGGGGSGSSRSNSFGGSNSSGGASKEFFYFDNDDMIQDDDLIPMLMQDQEHQLQTQYQNQQQVQQQQNIINSFINHENLKFPFSIIYTNKLHIWLSYFLFTFVLIFCCLAVGPLLWIELPPNSGCMWCRIFKLEWVISFMSLISAMFHYTIRRDMFPLYLSIIGFYHVLTYSEPFLEPFRVNNFFSLILTVICIFIAFYPKNKLRRQQASNHHQQQQQQQQQQRQRQQNNNRQPEKSIIKRIIQNEWFHSLIQILIVLGIVVLLFFSIFILALFMKDDKTFSGDVIDGNINSNNNNNNNNNNNINNNNIDNNNNNIKNNNKGFIEEIEQGEEQLELYLENAYHIFKELVFKKFISSSVVYLILITLLFCISLVYHWEVRKPYTLMALASMIPQLTQALYKVELTLTGVMDKGTMSHNVTPLGGGIFYILNVISYTSFYCGLAIDVVVASGEKYKRLKKRGEKYHRRLSTQINEQNAFVNKIYASGTAQLLQKVEFMQKFVDKILFSTLEISNRLQRLESSDQDIPSSLVDQLNDIQYQTNRSLLLLNDTKLILAIESGVISREDVSVNLFDFLEDVLERTSKDIKFNNIELVYKIDKDVPLNIILDPTALTQICFQLLSNAIKYTEEGEIGILIKRILRNDYEYQQEQQQPQQDNELPPFGTISEEDEEYNSNNPPPPLNQQQQQRQQQQQQEPKQIYLEISIFDSGPGMDDDELDICNQFQPFPDIGDEDDIEIKKKGSGLGLLICNKVLKSIGGDLIVERYLETGGCIFKCCIPVLVDPQPKENFTFQIPLSQETNELLSDLSVLVIDDNPYARDSVGFIFSSVFNSAIVKSANSSVEGVRDLKYAIATDSNFKLLLVDYHMPGCDGIEAIQMIVDNPAFSDIKIILMILPSDSFAHMNEKTKNITTLIKPVTPTNLFNAISKTFKLKEFSSVVDLVDLNAPDTSTQIPLKRNRLKFKIDFPFRLPETGKPIMRVLIGESDKSTQSKIQKVIESFGYFSTFVTDGTALISLSKKNYYDLVIVDLELQSTDGFECAQIIRDTHGEIFSNTIFVPKPISTNSNDDNNNNNNNNNNNNNNDNNNNNNNNNNNNNNNNNNNNNNNNNNNNSILTSSVDTDGNHIVSSSTSTSSSFPTRRSSIGSFQTASPSMTEISHRRRVKLPIIGIWHHSDIIPDDIIKKIKRVGFDGYCSFDNLEFYLQEFLLEFDRKRKSNILSPIRLFPNGSPSTNIYDYSSIISNLNQASGNNNNSSPISGILNENVISSPISLDLDLNSVSSIQSQSSSSSSSFQHNNQQQQQQQHQHQLTPTQQSIGGGNNGINQLSFSSQQSTPIFNQSQIQHQIISNRSKHSSLSSSTSSNGSGGSGGKSRFSIPMLPSSTNRDSSPHSSSKMALKRVQDLESVISKFVPIEFQQLIAPSGMENVYLGDAICKSITIFFSDIRDFTSTTEKMLVDDVIDFLNTYLAFALPSITDSGGFIDKFIGDAIMAIFPNSDMKLQAINAVKAAIRMMRSLDFMSISGFRFSSVETGVGINTGKTIIGIVGTENRMEPTALGDAVNLASRTEQLCKEYQSRILITQFTMEAIGTSIDEFVIRLVDSVTVKGKSEAVNIYEVIDGEREDKRVLKMKILPWYQNGMDLYKRHCYEEALSYFQLCTEIMPNDKPTLIYIQRCIQNIKTLELQQIQLQQLQRQQLLQQQQQQLLLQQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSQNIQQPQSQQSQYVQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQQQQQLQQQQQHQQQKQPSPQQQQQPQQPQQQQQQQIQNQYQHQLQYQRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHQQQQFQQQSQQSQQQSQQQQQQQQQQSQQQSQQQSQQIQKKSQHPHSQQIQSQRHQSQPQNVDTNVKTKPQQ
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. bS1m functionally interacts with the 5'-UTR of mitochondrial mRNAs (By similarity). Plays an essential role in mitochondrial translation.
Subcellular Localization:
Mitochondrion.
Sequence:
MSFAQILRGSRAMASPKCLPESNYSTSHLRFPRLQSITSKKNSRARGDWGLKRTLPKIKTRYICVRQQDSLYKQADFQSSAKFVRLVRNWFDAGFVRDPSEVALLQELLKETGLKDTRDINKVFSPSKQSDENDNFRRYGVSGGIQYSNVPLINSRVTPNCESNCSNIRRRLTAHIISSDASTAYYGLGGLILRLPRTVVFNRNRSSPLFSQEQRISYTVYKNGRLRLVPFSGPELETHLAYPSEDSEVESFFNRDIQLVAKRDSSLDAPVSYQRGIMKFFMAPSQTSNNEANSSEKDNLSNS
The following text describes a protein:
Function:
Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (By similarity). Phosphorylates RPS6KB1. Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalizes with APBB1 at the nuclear speckles. Colocalizes with PIN1 in the nucleus. Colocalizes with ATF4, CIR1, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis (By similarity).
Domain:
Displays an autoinhibited conformation: Tyr-108 side chain points into the active site, interacts with the activation loop, and blocks the alphaC helix. The autoinhibitory conformation is released upon binding with NEK9 (By similarity).
Sequence:
MAGQPSHMPHGGSPNHLCHVLGPAHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGIVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCIYPDPNHRPDIEYVHQVAKQMHVWTSST
The following text describes a protein:
Function:
Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. May play a crucial role in GPI-T complex assembly in the luminal layer (By similarity). Binds GPI-anchor (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MAAAMPLGLPLRLLVLLLVGRGCCGCAEGPRDSLREELVITPLPSGDVAATFQFRTRWDSDLQREGVSHYRLFPKALGQLISKYSLRELHLSFTQGFWRTRYWGPPFLQAPSGAELWVWFQDTVTDVDKSWRELSNVLSGIFCASLNFIDATNTVTPTASFKPLGLANDTDDYFLRYAVLPREVVCTENLTPWKKLLPCSSKAGLSVLLKADRLFHTSYHSQAVHIRPICRNAHCTSISWELRQTLSVVFDAFITGQGKKDWSLFRMFSRTLTEACPLASQSLVYVDITGYSQDNETLEVSPPPTSTYQDVILGTRKTYAVYDLFDTAMINNSRNLNIQLKWKRPPDNEALPVPFLHAQRYVSGYGLQKGELSTLLYNSHPYRAFPVLLLDVVPWYLRLYVHTLTITSKGKENKPSYIHYQPAQDRQQPHLLEMLIQLPANSVTKVSIQFERALLKWTEYTPDPNHGFYVSPSVLSALVPSVVAAKPVDWEGSPLFNTLFPVSDGSSYFVRLYTEPLLVNLPTPDFSMPYNVICLTCTVVAVCYGSFYNLLTRTFHIEEPKSGGLAKRLANLIRRARGVPPL
The following text describes a protein:
Function:
Required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with WEB1 to maintain the velocity of chloroplast photorelocation movement via cp-actin filaments regulation.
Subcellular Localization:
Cytoplasm.
Sequence:
MGERNLDGTVSVKATINKYGQKATRSVIKSSVAEDLHKSGRELGIYRESRRVAESAKAKAEVELCKAKKIVKELTLRIEESNRRLKSRRIDIEAVMNESRIDGNGGYVRIMRELEDMKQELSKLKLDVVYVSREKVVAEKEVMELESRMEENLKLLESLKLEVDVANEEHVLVEVAKIEALKECKEVEEQREKERKEVSESLHKRKKRIREMIREIERSKNFENELAETLLDIEMLETQLKLVKEMERKVQRNESMSRSKNRAFERGKDNLSVLKEVTEATEAKKAELASINAELFCLVNTMDTLRKEFDHAKKETAWLDKMIQKDDVMLERLNTKLLIAKDQLEAVSKAEERISYLADNLTTSFEKLKSDREAAKKEELKLREEARIINNEIQKTETGFDGKEKELLSKLDELEKAKHAESLALEKLETMVEKTMETREMESRRNSTITISRFEYEYLSGKACHAEETAEKKVEAAMAWVEALKASTKAIMIKTESLKRVSGKTMLEEERESFRMQRSLSIKRLVQDEIQKFKGNSEDNGLINSPKPVRKSVRLSGKFAPVQGGKSRRYSSGNRATPTFFVIKKKKKVPNMVKFFSRKRRNSSLEQ
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MGTFSLIKSITQPIAVVLSVLVNSVLILLVVTNSPRKMGSYKYLLIYFSALTIVYAANDFVSAPYMFNDDSTVVVLVDLKNNLLKDRPDLLLLAVVSGVSCFGISLYAIAINFMYRYFAVQREGRLRYFSGCRLVFWISLSIIGGIMTGLTFYAIGSRQEISHGLRENLETMYDLDMHRTQYWVFLYWQPKDGNQDLTAKDIMANLGLTTSMVIPILLIVFFGTKTYRKVKNLTTHGKSEYSKRLQMQLYKALVAQIIIPSVFLFLPTLLIAAGPLFKLNIPWASLPLSILFSMFSVMDSIPIIFLVDEYRNALFEFFGGFCCVNEVVPASARDTSSTQL
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKPRKKPEKNAPNPFEIHINKQKMTVLGQKNKNDRGLPGVSRAKALKKRKETLLQEYKLQNKSNKFTDRRIGERSRDLTSEDKLMARFTALRKKAHKKSIFNLADDEVLTHKGQTLAEIEKFDDPRSDNEDSDEDKSGKLDSAFVGDAHFGGGVLRKTGKEGAKTHRELIDELIAESKKRKAEKQRTKEATLELTEKLDTEWKDLLPLVSRAQKGEPDKGAVDDYDKVMRELRFEARGTVSDRLKSEDEVAQEEKQRLEELEEKRRERMRGFEPKTQKHRSADDLDDDVYEADPEYMLSYNTEGEANVEIGAEINGKTVGGEESDEEEECEEEEEEQSDDDLADLKAETSDESDEETEAKATKTDVVAKTDETSADLPFTFALPDSYEALQQLLDDKSSRQQATILERMVKCNHPSLAEKNKNGLGTLFVYLLQYLNDCASEKSAARLFEIYKSLAPHIFDLAQLNKENTHSSMLEVIKEKHDEFKKRPKDFPGLELLVFFKLVSLLFTTSDFRHQVVTPCFVFIEQILNKCKIKSGKDIAYGIFLVTLVLEYTSLSKRVLPTAINYLGGILHMAIPKCGVKLIKVNPPFKPTTSSLVLVEKSCEDCDFKMEASDLERDEINDSFKIRAIYTVLRLVQDFDNNLVSLPSNVEIFNDIRAYLELLPTRNYPKKVADLFESVSQQLKNRKVERKLEYIVLAAKRPKALRLYEPKIVEVFDGKKRKIQSREKAERDKLLHKLKKETKGALREIRRDKAFLGRVKIHQRIQSDNERKEKVKRIYAEASIQQSELNSLDRKKKRK
The following text describes a protein:
Function:
Plays an essential role in the initiation and regulation of chromosomal replication. ATP-DnaA binds to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex once per cell cycle. Binds the DnaA box (a 9 base pair repeat at the origin) and separates the double-stranded (ds)DNA. Forms a right-handed helical filament on oriC DNA; dsDNA binds to the exterior of the filament while single-stranded (ss)DNA is stabiized in the filament's interior. The ATP-DnaA-oriC complex binds and stabilizes one strand of the AT-rich DNA unwinding element (DUE), permitting loading of DNA polymerase. After initiation quickly degrades to an ADP-DnaA complex that is not apt for DNA replication. Binds acidic phospholipids.
Subcellular Localization:
Cytoplasm.
Domain:
Domain I is involved in oligomerization and binding regulators, domain II is flexibile and of varying length in different bacteria, domain III forms the AAA+ region, while domain IV binds dsDNA.
Sequence:
MFLEEKLNLVWNKILEEVSKKISPQYYERFIDTLKLETINSEKCTIIAPSATIKTHVERKYQSIIENAILETCGDKIPVEILIETKAASPLQSILEKSFDQKDFQFNPDYTFETFIVGDCNRLAYTAAKECVRKPAEINPLYIFGSVGVGKTHLLHAIGSELTKKDPWKTVCYVDISSFMNEFRFALQSRELIESFKIKYQSYNCLIVDDIQLLSTNAEKTQDEFFALFNFLFERKRQIVIASDRPSSELAIHERLKSRFVTGVQADIQYPDREIRKGIVTHHSKIMDLGLSEDILDFLADQIEEDTRLLLGALNDIYLYKKSYSLLFLNLDKVKEIVKNRLYRKKNIEFSHDRIIEAVAKEFNLNTAEIMGKSRKKELIIPRHICFYLLHNVFNVNKSQVGRLFQTQHTTVIHGVRKTEELLSNNKEMRFLVERISSKYKLQ
The following text describes a protein:
Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MEEKKETQDLAQLKKEMLGTAIIKDTDMSPDMLSEVQDSIVSGIENNSSPVLSIENACKTIKEALEKKYGPTWQVIIGEGYAYDVTVQNNTRLFMFYNGNLACLVFKS
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Sequence:
MSKRFSTGQSNTLLNYFQSPKSSNGKDVKQNGAGKRDLVSNKDEGDVSPVQAKKRKKTTIIDSDSDDEHLPIQPTSKKSKNGKKRPVSDSDSESSDSDSKPAEKSLKLSASKTNEKSAAKAAPIVSDLNTNWLHNRLDFLQPDKIRDVNKRRPDDPDYDPRTLYIPQSFLEKQTPAMRQWWVLKSTHMDSVLFFKVGKFYELYHMDAVVGVTQLGFSYMKGEFAHSGFPESAYHKMANALIEKGFKVARTEQTETPEMMAERCKKQGRATKFDKVVNREICQISTKATCVYTAQLPDAMHSQSCYMYAIAEKDVTGSQRRFGICFIDTSIGVFKLAEFDDDKHCSKLLVCLSEYPPGLILTERKKLSSKLKLILNTNYRDVRRESLAPESQFYGASTTIEKLLNGNYFRNESNDLCLPEVLKNVTDGYNAKPEFELMVKALGGCLWYLHDSKLDIQVVSLGKFEIYQPLEMNVREKSPRSCMILDSVTIVNLNLLGEENSLQKTLDYCQTAFGKRLLTQWICRPLCVVEKIKERQEAVQELVKNTSLLKDAQDVLKKLPDLERQLAKIHTYGNKFFAQDHPDSRAVFYEAATYSKRRIGDLLKTLQGFELAQNLCPLFKGCQSSLLKRLTQFKPDGHYVDLTELLLFFKHAFDQEEAQKEGKIIPKPGVDENYDQAQDAIKAVTKKLDEYLVELQQFFGCKVTYFGSDKKRFQIDIPESHTKKVTSEYQLEGTKKGAKPSKRYSTSRSRQLLAEMMKAESERAKVIQDLNRRIFQKFSEKREQWEQAIDCITVLDVLCSLAQYACNFGQDICIPEIEPMGNSDKIVIENGRHPCITNIDNFVPNDTKMGVADFANILLITGPNMGGKSTLMRQIAIICIMAHMGGYVPASGCTLSLIDRIFTRLGAHDDIVQGQSTFLVELSEAAVMLHHATPHSLVLLDELGRGTSTHDGNAIATAYVEKLTTINCRTLFSTHYHSLVDHFEARRDVQLGHMACMVENDDDPTEESVTFLYKMARGRCPKSYGFNVARLSGLKHCIVSRGREISKQLENESKSRQVFRDLFTSSVATIRSAMSKLSLS
The following text describes a protein:
Function:
Secondary manganese efflux system. May prevent manganese intoxication.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADGLNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSAGESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAFVSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAYKQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHAIDYSHVHMEPLEQK
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Miscellaneous:
MISCELLANEOUS: Present with 2250 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLRTSLTKGARLTGTRFVQTKALSKATLTDLPERWENMPNLEQKEIADNLTERQKLPWKTLNNEEIKAAWYISYGEWGPRRPVHGKGDVAFITKGVFLGLGISFGLFGLVRLLANPETPKTMNREWQLKSDEYLKSKNANPWGGYSQVQSK
The following text describes a protein:
Function:
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity).
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Basal cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with PDZK1 on apical membranes of kidney proximal tubules. In intestinal cells, apical expression is induced by TNF.
Sequence:
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLSSAWRNHSIPLETKDGRQVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQESCLDGWEYDKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQVFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSELQDLNSTKPQLHHIYDLIRTRNIRVITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFFPESFGVPLPDTIDQMLRVKGIKQWQIQSQTRMQKDGEESPTVLKSTAF
The following text describes a protein:
Function:
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity).
Sequence:
MPNKKAARNAYFFFALDMIPELRRRGLQVSGVREAIPLCSEDWALLSADQKEAYAEKARLLKNDPDSTSTYNDGVFGQRKRNATKSSDFSSVGFFQLNDQRNCVTQRTVPAMNIDISFNKNKAPDQHVCYFINIFSHGDMPSLCEQRYVPCEIACVRYSLREGILGSFHDFIDPGELPRGFRYHCQSGSASTHQIPISGFELANSDYHNMFRKLCSFVCPTPCPVVPVYTKANDIYRVDWCLQWLANKAGMENHFRVQEVETLIIKFYQDKLQEEPSRPTVSRLLDVVQWDYSSNTRCKWHEDNDMWCCALASCKKIAYCISKALASVYGVTLTPAHLPNPERSRNQNSVNPKVVVLDAKRFQRVCSSDPKYSTDKSERSSFEPRGVKPYQGPSGGGRGILRLLETLAASQNSSG
The following text describes a protein:
Function:
Component of the aurora kinase complex, also called chromosomal passenger complex (CPC), essential for chromosome segregation and metaphase chromosome alignment. Mediates the SLI15-BIR1 interaction within the CPC.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Note=In G1, localizes along nuclear microtubules and at spindle poles. In late S phase to metaphase, is seen as a few small nuclear foci and also localizes diffusely within the nucleus. Also found along the spindle in early anaphase, at the spindle midzone in late anaphase, and finally concentrated at the plus ends of depolymerizing microtubules before mitotic exit.
Sequence:
MIPALTPEERQKLRSAILHRMQLELETTEKLIENIKEETLKKLNLLQQPDATSAPQSKELIREVLEQEGRRIE