The following text describes a protein:
Function:
Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MDVLIEWVAIYPQIYDILEHINYVPSNTLQRLRLHQPWSKIDYDVWFLYASDEIRETCKVKYYGETKTYGEVFVLENERISQLHRLFVSWTVSERAEHLKNLLFDAGLSNLPLVELGGNVFFNSHVPLPCSLVLTKSTQENLNRITPYLVQKRPILLAGPEGIGKKFLITQIAAKLGQQIIRIHLSDSTDPKMLIGTYTSPKPGEFEWQPGVLTQAVITGKWILFTNIEHAPSEVLSVLLPLLEKRQLVIPSRGETIYAKGSFQMFATSSMKTKILGQRLWQILDLTYQPDECVEVVSTLYPVLSIICPTLYSVYKDIFDLFSQRSFLATSKIYRRLCLRDFYKFIKRVAFLYHKFMIPSDHVVISQELQDAVFKEAIDMFGAFIPSRDGFDLVVRNVAIELNIPPEKALQLRYSIPVFQNLEHNINIGRCSLKKLSTIRSCSTNSYAFTSSSLGLLEQLAAGVQTNEPLLLVGETGTGKTTTIQLLAGLLGQKVTVINMSQQTESSDMLGGYKPINASTLGLPLHERFIDIFEQTFSSKKNAKFISMASTSARRFRWKTCLKIWKEACKLSKTVLDGQQPLPNPQKRQKRLSNQVELRNQWAKFEKEVEDFEKVLTGGSNGFMFSFVEGALVKAVRSGHWVLLDEINLASLETLEPIGQLLSSYESGILLSERGDITPITPHKNFRLFGCMNPSTDVGKRELEPSFRSRFTEIYVHSPDQNLDDLLSIIQKYIGSLCIGNEHVIREVAELYQVAKSLSLDGSLVDGAGQRPHYTVRTLSRTLSYVTEIAPIYGLRRSLYEGFCMSFLTLLDHTSESLLYNHVVRFTLGELNRDQQNAILKQIPKVPDHSSYIAFCHYWLRRGSFPVEEQEHYIITPFVQKNLLNIARACSTRMFPILIQGPTSSGKTSMIEYVAKKTGHKFVRINNHEHTDLQEYIGTYVTDDNGSLSFREGVLVEALRNGYWIVLDELNLAPTDVLEALNRLLDDNRELFIPETQVLVKPHPEFMLFATQNPPGVYAGRKHLSRAFRNRFLEIHFDDIPENELETILHKRCKIAPSYAAKIVQVFRELSLRRQTTRIFEQKNSFATLRDLFRWAFREAVGYQQLAENGYMLLAERARDQKDKLAVQEVIEKVMKVKIDTDGIYNLDSMEIFQDMSLKEGPLSKVVWTRPMIRLFCLVWRCLLAKEPVLLVGDTGCGKTTVCQILAECLHKELHIINAHQDTENGDIIGAQRPVRNRSAVNYSLHSQLCEKFNVQESLDSIDDLIEKFEKLSSSEKNDNLSNLIERQIIKYRSLFEWHDGALVTAMKQGDFFLLDEISLADDSVLERLNSVLELSRTLTLVEHSNAAVSLTAKDGFAFFATMNPGGDYGKKELSPALRNRFTEIWVPPMVDTEDILKIVEGKLHNNKIELARPLVEYAKWHANEYLYTDVISIRDVLSAVEFINACEILDLNLVLFNAVSMVFIDALGSFTTFSLSNNLASLHAERQRCFAKLNELAGSNIMASKSADISIKFSDSSFFIGDFGIPLGDSVESDSTYSLHTDTTLMNASKVLRALQVLKPILLEGSPGVGKTSLITALARETGHQLVRINLSDQTDLMDLFGSDVPVEGGEGGQFAWRDAPFLAAMRNGHWVLLDELNLASQSVLEGLNACLDHRNEAYIPELDKVFKAHPNFRVFAAQNPQHQGGGRKGLPRSFINRFSVVYVEALKEKDMIEIAACNYHQVNEDWRLKIIKFMFRLQDNIEKDISFGSFGSPWEFNLRDTLRWLQLLNDAPKYTCVSPADYLEVMVLHRMRTVEDRVRTCELFKEVFDIDYEPRTIGFSLSSQCFKVGHSLLVRDVERQKTLLDSQNILQSQLPVLESVITCINKKWPCILVGDTATGKTCILRLLAAIAGAKIKEMAVNSDTDTMDLIGEYEQIDISRKASELFTDLSQQLLNIVIKYRNFDNIFRETSLYTLTTTSFKTHSQAFTLLQKVVDQLDQLKIHETLVHSLGDIHEKARKLLAEFSASPAGRFEWFDGYLLKAVEEGHWFVLDNANLCSPAVLDRLNSLLEHKGVLIVNEKTTEDGHPKTIKPHPNFRLFLTVNPVYGELSRAMRNRGVEIFLLKEALTEIDKKQMSLLEPAPISSAVDTLASNISYIKYVFETMGKIEIDGNYMYIAHAIILALFSPRQLKLLRKVLLTNPQFSLSIKADAELLLTLKNLVQKIYCADYFNHMDLKASRFMDIYEYPVQLREVVGLIQTINDFQSVILTSHLELPETYASGLLFVSAHEILDLTEEVNRLAVSTSNSTYLLKSASAVYHNVSSFKGSTPSLWNLLNQFSKFLIEIASANSNIVYKLSYDVIRHFLKLVVLWKNIYVWTNVPDCDISRFYCYTKMLGEWMFTLTEKTKLLESFLPKDSLEKFSELQNLSTGLHMQAIWDKWHAFVPRTYDQWSLWNTVDKLLTQYVNANIPSISMETTACEVVGTSLSLLNKVLVENEVGDIYSYLKILGKGVNELKSSKQVILPENLVNLFNCLASLDLLHIFIKYTTSSFFLTDDFVRFIRVCFHSRISGNLLTLLHGISFDSTKAVAPVLTYFDFCSLTTGNILGRIALAFTSIDENANLESANIFEHARLALLQHFMDHSSLLAEDSSTKMNLILLQRYAVIISIFLDQGKCEKANDLITKLSLPYEELAENFVSILEACKAFLVANSEFISYTYTERFIHSLRFLKDSWLSSNQQKMLKNQGMAYIYFASGMLLVYVPDKPFDPALLPLLTVESLRHYLESLYKESQILEIAESLNSGKVNSVMRRLVSTEISNTPNIDSSFSTVYRSLNESIVPLYSELEFFMKSVVLNQYIFELAMRLSKESNIAVVEEAKSFVTKWKAYIERIREAYPQFVDVYELILSFISFMIYGIELLMFEAKRRLDERSQILSTLILTLVDPSSFARSLSFDDVSNLIEQIKVLDLNDSIRFEIYLFLASRLCSEKQHSSDTHSLANSFVLLANEFYIHNAKIKQKELEEIEEKNRLYRQREFNFDKNDYLKVFINYDDEVEPEVEPEVVIERKRFLQLQFAFWSLYNEIYSEKMNVIPLEQLMNTGSYLAKKIKVKNPDMIASSGFDIVSVVLMMGVKSTNERQYWTPPVYNFYSDPNPSKAIEVRDLIKIVESRAISLIKNWPENFVLRGLKDAIDAILNLSPFSPIAEYLSKLERVFHLLSEWEKLASREYSLANEMDLIKKKIIDWRKFELSNWNNLLKLEEYKLSERVYPRLYSILQFIILKPFFENSKFTKQNLCESASIIVQFITDLTVGEFQLCLKCLLSFSQHAASLRICHGIDAMLLNIYHYFEQFLSKVSEAIHTQKQSLENSIKERILLMSWKDTNVYALKESAKKSHAELFKVLHRYREVLRQPVSSYLSQKHDWDSLLDTENNSAMWVAKKVNLSPSYIEKMDTEIMKLVPVRFSNTPTTLRLMWTLFANVEKPGSTFTNMVSNLITDARELMKLTPETINDDNLSEIKHLKSRKHLLLTETFKTLKAFGLQYRVKAGIEENLSNLRNLLAVIPTFPVTSLSIEKVDRSLMKSLDFIPKFQTLAGHQHNDLSVPEVQKGVGLFNSMLSLQLGERAQLVEFTNELLALKNVYSEVGVNGSPLESFNNSSFNEVSSLGYDHDFENRAQAVSMLCQIYAIVIQKHSSISPTASFQSIGHELSRFADLLSNKLFPSSIPLYASADKVSSIRDQQKGINDLIEYCRKKRTELPELSYCFKHLVSLQSLKSISRTQVDLTNDEFLNLMNFVLNLFDSLLSSIETATKNMRTFKELAETSSFIEMSSCFSKVLRAFNLKFQSMKLSSLKEKLRSSSVDKMSCQLLMLFLPVCEQFINLAESVLDYFINVHNSNLDSLSKISTLFFMVANNGFCSPDLPQEGKSNSGELESGTGLGSGVGAEDITNTLNEDDDLEELANEEDTANQSDLDESEARELESDMNGVTKDSVVSENENSDSEEENQDLDEEVNDIPEDLSNSLNEKLWDEPNEEDLLETEQKSNEQSAANNESDLVSKEDDNKALEDKDRQEKEDEEEMSDDVGIDDEIQPDIQENNSQPPPENEDHLDLPEDLKLDEKEGDVSKDSDLEDMDMEAADENKEEADAEKDEPMQDFEDPLEENNTLDEDIQQDDFSDLAEDDEKMNEDGFEENVQENEESTEDGVKSDEELEQGEVPEDQAIDNHPKMDAKSTFASAEADEENTDKGIVGENEELGEEDGAAESGVRGNGTADGEFSSAEQVQKGEDTSTPKEAMSEADRQYQSLGDHLREWQQANRIHEWEDLTESQSQAFDDSEFMHVKEDEEEDLQALGNAEKDQIKSIDRDESANQNPDSMNSTNIAEDEADEVGDKQLQDGQDISDIKQTGEDTLPTEFGSINQSEKVFELSEDEDIEDELPDYNVKITNLPAAMPIDEARDLWNKHEDSTKQLSIELCEQLRLILEPTLATKMQGDFRTGKRLNMKRIIPYIASQFKKDKIWMRRVKPSKRTYQVMISIDDSKSMSESGSTVLALETLALVTKALSLLEVGQIAVMKFGEQPELLHPFDKQFSSESGVQMFSHFTFEQSNTNVLALADASMKCFNYANTASHHRSNSDIRQLEIIISDGICEDHDSIRKLLRRAQEEKVMIVFVILDNVNTQKKSSILDIKKVYYDTKEDGTMDLKIQPYIDEFAFDYYLVVRNIEELPQLLSSALRQWFQQMSNT