lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MTESSSISMYHAAVHHIFRRWDAYEGIQADNFWLYQTSDFMTASPSSATASLLRLLTGNDMKGVPVLFMKAQRTVLFLPINERAHKTLSLFTGRSSENIETEVLLMGKGKPPPGLAEAMERLKASKTRTLGVMSADISIIEKSGNKLMEELRAQIASMPNFSMNIDVTELALDILSFIPSGYHSLLRAASQEALSCYGKVYNALEKTFGGGRCLESQRRTMLDAAINLACGGSADISKELSAGSGARYIQLTEQQLLALNKTSRLTASVSLVSTATKDTLDDSLSTVLRRALHASVLGHSVVNELQIVSASGPEPGRLALTNVICAVTRNGMTGAVARTVACAHISIAGAVRSAFEAVERVHRESFDLVKENTSLSSLAEQLLSARANTSSTLTCKRTNLSISLSFDKLELGGVCGAPTGAGVTTKEQALEALRSSGLAPLCLGQDSLSKRTAETIITGSTPLFLTTAAHVTIPDKGISFDIVYGDTILLALAHSNDTQHVLTGPDNMRNSTTACLRGFFMITESGETKAGGLATSLTQPSESSESDESSDVQVSVMRDRNIEERRHVRQERASRQKALNESQARLGLELKQRIEERFRAGRQKFRKEGVVREIAMAFSSVNDYPSAIGGDDSIIYKMTTSDSLFIMINSRPVPIHPNMIHSIKIAGTNEAGVTLIRMQLAAPGVVTGKARDNYPQLELYGTSNVFLKEILFECAASKAEKIVEELTNHLTAFRQKQQNELHRNEPIQIDMDIDNLMGEAVKSAILKPETISLFQSSNPYYFHLSSSNLNQPLQVRPNIERQRSKEGGGLHVHENGLLYLYGNPSRQIKICLLYKNIKTCVFEKLRDSSHIAILYFMFRTPTSIKQLILGDLPKGEYDETVLTKPQNGITFLCNFETGVRLSSGVKPKTDREEVEHERAAAQNMRKANKIYDQFLSCMNDALHAYEEKNPIYAGHLFKVCTRDRNYPSFFASYQGNQTFHIYKNRRLGCMEPKTQFIVAVEDLDMVVFENLNLYRDSTFHMTFHYRDIRMDPVTISSIQSKYVHELQDWVNAMGIKYYITPETTKWKDFTAKYYNKREDYVEFLEGGSWNAFFKSDSESSSEEQDDDSDAFQENSYDEDDEDDEITGSCATSEPDNLQGDDEFSSEVIDFEEESESDHRDYRRRR
The following text describes a protein:
Function:
Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner; Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B.
Subcellular Localization:
[Isoform E]: Endoplasmic reticulum. Golgi apparatus; [Isoform D]: Endoplasmic reticulum. Golgi apparatus; [Isoform B]: Cell membrane; Single-pass type I membrane protein; [Isoform A]: Cell membrane; Single-pass type I membrane protein.
Domain:
Isoform B, displayed in this entry, is the only one of the isoforms to contain both a transmembrane region and 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. The 2 ITIM motifs of isoform B are required for the inhibition of CLEC1B and GP6:FCER1G signaling and platelet activation.
Sequence:
MAVFLQLLPLLLSRAQGNPGASLDGRPGDRVNLSCGGVSHPIRWVWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFVGRLRSLDSGIRRLELLLSAGDSGTFFCKGRHEDESRTVLHVLGDRTYCKAPGPTHGSVYPQLLIPLLGAGLVLGLGALGLVWWLHRRLPPQPIRPLPRFAPLVKTEPQRPVKEEEPKIPGDLDQEPSLLYADLDHLALSRPRRLSTADPADASTIYAVVV
The following text describes a protein:
Function:
Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Is involved in various redox reactions including the reduction of protein disulfide bonds, through the reversible oxidation of its active center dithiol to a disulfide.
Subcellular Localization:
Mitochondrion.
Sequence:
MAQRLLLGRFLTSVISRKPPQGVWASLTSKTLQTPQYNAGGLTVMPSPARTVHTTRVCLTTFNVQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAIKNGDVVDKFVGIKDEDQLEAFLKKLIG
The following text describes a protein:
Function:
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
FYTGDHHKDFKGLSAEETKQKLEQLVKSEVDLDKDGFVTEDELRLRLLNTSRKHRKTEVNSTVTFHDDNKDGKVSWEEFKKAHFTHTEGKEDDKATKEQMAEDEAKFKYADVNGDGMLDLHEYVTFYHPGDDERMSAWVIQDTLKKHDTDKDGMISKSEYMATFSDANNDAKIELEKDFDTSFDKNKDGKLDQTEIRHWLFPDDDMAKEEPAHMIKEADDNKDGKLSMEEILKHSSVFVDNGETPEHDEL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Domain:
The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.
Sequence:
MDRYDMEDVVVAPPAECSSPLKEWRLKRQAGTLDRSDIIEFLKRESPKYFDYQTSATVKDTNVITLKCMFKESLAKEEIIDVVVEFMLGDNPSSALEKLRLEGNTATVCGKVFKNGEPTYSCRECGVDPTCVLCVNCFKRSAHRFHKYKMSTSGGGGCCDCGDDEAWKKDQYCELHLANRKNPLESKILTDAVLERVEICFGAILAFCVSYLEIEPNASLQCLDGNVEGGQVDGAQYCTVLYNDESHTFDQVIQTLTKIAKCRAKDAMEIVAAIDREGRAVVKCDTFEECNKLKVSIENQMILPTSLVSTARNNQSLRTSVLHIGAVACQQFALQLLGWFQEFLVRHYLFRKTFSELVQRKQETFCIRHILEYDVKLWKTARTCWHRLLISGMLMEYDNKMILAQEFSRRYATIVEDFISDDHDHAFSIVSLSVQLFTVPSIAHHLIAHEGIFDKLLHTFYHVAIEKFIRNKTLHFSKNIASLTFFKRANYILYDLRYLLSLKPDVLSNDLRNGFLEGCRALMRVLNVMQGMESMTRQTGQHMDYEPEWECAFNLHIKLATTISQVIDWASGDVKLLRKLYKMTMRALVSNSFIVGGEKVMQPKKVADHVANCLVYDISVQPVSIHLPLSRFFAGIYLHLGAHDLTYDGLQTETEALSIKLTPREIIEPVLCTQAMIAQVGAGLWRRNGYTLLHQLYFYRNVRCRVEMLDRDIACLQIGASLMESNEFLIHVLNRFNTIPWLQENYWSLLSGNEMNDDIIREASIFDEFLELLIVIIGERWMPGVSMVTEEDRLRKEIIQLLCIKPYSHSELSRALPDGNSGNSDNVFEEVINTVAVFKKPVGADSKGVYELKEHLLKEFNMYFYHYTKEDKSKAEELQRERRKAKKQLVCCPPPMLPKLTPAFTPMANILQCPVFLNICSLIMERALNAYSRSFTESHLQKVLHLLGYAIQEELSEHYPFLSFYERSQEYGILEKLEELARCPRLEAHYDFVLWTIERFKQLQAKQAPSDGRAGPSCSQQGTGGKLSLSAEEQAREERENRARLAAERRAHIMAQMQKAQKSFISSNAEMFADTENETRKESASTGPMDWEDIPPEEEQGAVALESKVACLGPDRKFYHGTDDTFKCILCFENCAISRGGRQLVSSAFVQTSRVIFTTPNLRNSQSALHISCCGHVMHYSCWLEYFTNEEFKELRRPHRNRAALAQAANVEFQCPYCRTLSNAIIPVTETLPAFSAPPSPNESYLPLDSFVEIMSTLAIELGNVKDHELTTLPSVSNILRLSGVVGGLAQFERSVQLIKNPPRLHADYIEGIEFLKKALLNTMKIQQSHLKDHPAIESIEMVPILWDSCSYTLQALEIYLYAVEKPLKAELSMRHQSCARNLVRACSRSSALEWETDLPLLPPMRSQAEFSSRLLDTIFNQNDTSVLEWDCFRVLVPFQFGVLNLMVPEKGYKTIIPSGSMFDFYIMQTMFLAQLTKAVLCFDVEKEKAKRAEKAPNSELTQLDYIEQLPSRIRDNMIDFYRRYNIPARVLQKTKQKQLVEEESEENQGHGQTVVIPCESHHLALLLEYVQRQMSSFLRCSCLFYRFLTDVDFPDTFPTDQPDRFDLMCQYLGLDPMLGVYFDMETVYATMMHSFASHPHIDREVEQRCQPDARRSLQVEPCLRPLPRLKVLCDDFSDLINSVSDIFCPNNEREEMKTPTMCLICGLILCGQSYCCQPELGKVSVGACTHHAHACGAEVGIFLRIRDCQVVYLGRGKGCFVPPPYLDEYGETDMGLRRGNPLRLSQAAYRKIYLQWLGHGLHGEIARLNDNANVAAAAQWHHM
The following text describes a protein:
Function:
Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.
Miscellaneous:
MISCELLANEOUS: It is unclear whether the N-terminus residue of the mature protein is Glu-30 or Ser-46.
Subcellular Localization:
Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin.
Sequence:
MRPVATGIFKALVFIFSSLCAWYSGYLLAELIPDVPLSSTLYNIRSIGERPVLKAPAPKRQKCDHWSPCPPDTYAYRLLSGGGRDKYAKICFEDEVLIGEKTGNVARGINIAVVNYETGKVIATKYFDMYEGDNSGPMAKFIQSTPSKSLLFMVTHDDGSSKLKAQAKDAIEALGSKEIKNMKFRSSWVFVAAKGFELPSEIEREKINHSDQSRNRYAGWPAEIQIEGCIPKGLR
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Sequence:
MAQYNHFKSLYPDAILLFKLGDFYELFNQDAIESSKILNITLTTKRIGENKSMGIPMCGFPTHSSDIHIEKLIKVGKTIAICDQVEDAREAKKNGRVIKREVVRVITPGTIFEERFLKSSQNNYLCNFLPVNYHQKDFSNQVLYNNTSRFSISWLDLSTGYFYTTETTYDNLLSELTRISPNEILLPKSLIENPSISKLIKSFNISTESDEIFKIKNTLSKFNETYNLNLNYNQLINSNGFFDGTSERNFSIDELNSSGSILNYVINTQMGNIPHLYPLKKFSSSNTMSIDFSTMQSLEIIKTLQNQKKGTILDCLDKTLTSSGSRLLYSRIQSPSLNINEINNRLNLIEFFYENLDITKEIRKLLVRCLDLERCLQRVYISKAGPRDLSGIGSTLAISMEIKRILDERIKKLKPTPQINNLVENINNKLNDFKQLLLYLSSALVDNPPFNTSDGNFIEKGYSKELDNTIKARDNSKELVQEIQKKYRDQLSLPSLKIKHNQIIGYYFEIQSTFKNKIPSNFIHVQTLLSHMRFKSEDLLKLEDEINISVSKALEIEIGLFNQLCKLTLSFGDQIKETSDVLSIIDVSTTLALIAKERLYVKPIINETKSLKVINGRHPTVELVTKNFISNDLVLNDDSNNHEKEDETLLWLITGPNMGGKSTFLRQNAIIILMAQMGSYVPADYAEIGIVDQIFSRVGSSDDLSNDRSTFMVEMVETAQILKKATDKSFVIMDEVGRGTSTLDGISIAQSVIEHLVSDNKSRTLFATHYHELTKKLNQEQDQFISKKIKNYCCIIKEHQGEILFAHKIIPGIANKSYGIYCAKLANLPEKVLNRANSILTNLENNNKLF
The following text describes a protein:
Function:
May play a role in a redox process.
Sequence:
MNILLAFKAEPDAGMLAEKEWQAAAQGKSGPDISLLRSLLGADEQAAAALLLAQRKNGTPMSLTALSMGDERALHWLRYLMALGFEEAVLLETAADLRFAPEFVARHIAEWQHQNPLDLIITGCQSSEGQNGQTPFLLAEMLGWPCFTQVERFTLDALFITLEQRTEHGLRCCRVRLPAVIAVRQCGEVALPVPGMRQRMAAGKAEIIRKTVAAEMPAMQCLQLARAEQRRGATLIDGQTVAEKAQKLWQDYLRQRMQP
The following text describes a protein:
Function:
Interacts strongly with CDK4 and CDK6 and inhibits them.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLLEEVRSGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
The following text describes a protein:
Function:
Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
Sequence:
MLPTAVLLVLAVSVVARDNTTCDGPCGVRFRQNRQGGVRIIGGQDAAHGAWPWMVSLQIFTYHNNRRYHVCGGSLLNSQWLLTAAHCFRIKKKVTDWRLIFGAKEVEWGTNKPVKPPLQERYVEKIIIHEKYSASSEANDIALMKITPPVTCGHFIGPGCLPQFRAGPPRVPQTCWVAGWGFLQENARRTSPMLQEARVDLIDLGLCNSTRWYNGRIRSTNVCAGYPEGKIDTCQGDSGGPLMCKDSAENSYVVVGITSWGVGCARAKRPGVYTSTWSYLNWIASKIGSTAVHMIQLPTASPASTPGAQASSGSVQPSVRPPWFFQQIT
The following text describes a protein:
Function:
Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (By similarity). Does not fold G(s) G-alpha proteins GNAS nor GNAL (By similarity). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm.
Sequence:
MEPRAVAEAVETGEEDVIMEALRSYNQEHSQSFTFDDAQQEDRKRLAELLVSVLEQGLPPSHRVIWLQSVRILSRDRNCLDPFTSRQSLQALACYADISVSEGSVPESADMDVVLESLKCLCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLLTDTLELTLGVTPEGNPPPTLLPSQETERAMEILKVLFNITLDSIKGEVDEEDAALYRHLGTLLRHCVMIATAGDRTEEFHGHAVNLLGNLPLKCLDVLLTLEPHGDSTEFMGVNMDVIRALLIFLEKRLHKTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGEMLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVTMFDKLSRNRVIQPMGMSPRGHLTSLQDAMCETMEQQLSSDPDSDPD
The following text describes a protein:
Function:
May play a role in maintenance and/or transport of vesicles.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSCSRPCVCSHGTSVEESTWYGFDFYPNLFYNDWLGTTTLPYNPERIPIRYINRPWPSLCWKVTVAVASLFLLLGVAALTTGYAVPPKLELVNESKFSSMEDPVADYNQALMTCRVVGATLCGVAGIMLAVCLFLIASGWMFQDIKAEPLVTETDSPVEVFRDEPEKLSPAFHETSSQSPFLTPPSPFGQQSVQTSQPQRDL
The following text describes a protein:
Function:
Sperm-specific intramembrane-cleaving aspartic protease (I-CLiP) that cleaves distinct tail-anchored proteins and SNARE proteins. In elongated spermatids, modulates intracellular Ca(2+) homeostasis by controlling PLN abundance through proteolytic cleavage. During spermatogenesis, processes SNARE proteins and impacts vesicular trafficking which supports compartmental reorganization in maturating spermatids and may play a role in formation of the acrosome; In round spermatids, acts as a scaffold protein supporting FREY1 in IZUMO1 recruitment at the endoplasmic reticulum membrane and coordination of IZUMO1 complex assembly. Stabilizes FREY1 at the endoplasmic reticulum membrane through interaction. May recruit IZUMO1 interaction partners; [Isoform 2]: No difference in cleavage specificity compared to isoform 1.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein; Lumenal side.
Domain:
The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP.
Sequence:
MACLGSLHPLGSLLLLFLLLLLSPEARGEYGLVRVVSKNWSKDYCVLYSSDYVNLPRDLHHAPLLSLHDGTKTPWCPDEDSFHQAQDSSPRQRPLHQTTTMVTRGNCSFYAKGWLAQDQGAQGLLIVSRARNQQCSDTISKPQDPSKPWPALTIPVAVLRYTDMLDIVSHTYGDTDVRVAMFAPLEPVTDYNMAIIFILAVGTVAAGGYWAGLMEANKLQRRQAQRGGGLGGHNQQQTVAAERSQRAWEDDDFEDAPMDFTPAMTGAVVTMSCSIMILLYFFYDCFVYVMIGIFSLGASTGLYSCLAPILCHLPLWRYQWVLPGQRVSVTWPLLLLAGLCAMVTVLWVIHRNEDHWAWLLQDTLGVAYCLFVLRRVRLPTFKNCTLFLLALLAFDVFFVFITPLFTKTGESIMVEVASGPADSSSHERLPMVLKVPRLSFSALTLCNQPFSILGFGDIVVPGFLVAYCHRFDMQVQSRQVYYMACTVAYAVGLLVTFVAMILMQMGQPALLYLVSSTLLTSLAVATCRQEFTLFWTGQGRAKIPAEPVAQPCIASAVGSKMKLEDAKDSRTTNRFEQAVDGESGDLESSTGDDMAEMVTLSEDEATSPEGHSESSEGWSDTNLDPNELPSGSPMALEAMLIPLIQPIPHPSELGHIRTQSRVHDSSLPWMGLHKRKGLKVKKSMSAQAPL
The following text describes a protein:
Function:
Peptidyl-alpha-hydroxylglycine alpha-amidating lyase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides. Mediates the dismutation of the unstable peptidyl(2-hydroxyglycine) intermediate to glyoxylate and the corresponding desglycine peptide amide. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
Sequence:
MAPGMRAVLTGICLITLGNICLAYPTWDNPWWPRDLLEKFDTTFEELERQRPPQGPFVCTTLKSWRVENLIASGTEGDRIDRIIGYGCEQPASSQTTWICEPSRPDTVCAGPVLGTVFNWEKEREAGPGQTSMMEEEDVEVGPGDINTVVLAMRFTDDGEEEGQEEGAVQEDKNKEDAQSVADRGTDDSSLQVEEDWPVQNLELGQVSGVAVCPAGHVHVFHRGDRVWDSSSFDDDNVYQQQDLGPIQTDTVVELDPSTGDLVRSWGKGIFFLPHGLAMDGDGNYWLTDVAMHQVFKFPASGDSVPLLTLGEAFQPGSDDKHFCKPTDVAVDDSTGDFFVADGYCNSRVMKFSKDGTLLLQWGRPSPQGYSLSGPPPGTFRIPHSLTMVQDRGEVCVADRENGRVQCFEIKEGKFRRMFREREFGGRVFAVDYNPDQGGVLHLVNGPTLAGATLPVEGFTVRFSDGEILDTWRPTPRGFSQPHDVASAPDDSAVYVVEIGPNKVWKFVPANEQPNVILPA
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Sequence:
MSSTTTNTTTATPAIQVNGNQSSSPQSPSSSTSTLSPPMSPSLLTRYREQKAVNKQIEKQLKEEKKIMDSELKLLLLGTGDSGKSTVVKQMKILHLEGYSQEERINQRQFVYRNIIEIAYSIIRGCGVLNLTIPSQFDSICSSIEEIYETKNYTNLDKNVLKGVAELSKNESFINAANNSGSNFQLHSSSQYFLDDIARFSEEDYIPTDQDILYTRVASTSVSETRFSVRGIKFRMIDVAGQRGHRDKWIHHFSEVTAILFVISLCEYDQVLEEDGKTNRMIESIKVFGDIINQRWFKDIPIILFLNKRDLFAEKIKKTGISICFPDYTGPSDDYEQSLVFLKKKILSANKTSKAVYTNVTTATDTTNIGHVFEAVKDILTRQTMEEGGI
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MLSNIPISAIRAFEAAARTGSFRDAANELHLTPSAVSHAIRKLEGTLRTALFERSARSVRLTPAGENLMRHTGAAFDQLRRGLEEVAARGPQLVRVHSAPSFAAQWLAPRLAQFLAAYPKLEVRLAASTDYARFSNDDFDIDIVYGPPRAEGVEIVPLPEETVTPLCSPSLAKSIRKPADLLDQTLIRSDVKRVQWHQWFTANGLEAPALHGMRFDRSFLAIATAAEGLGVALESTLLAERELACGRLVAPLAGRANDIRYVGHRLIYPRASRQRSSVRAFADWVVAQLGGGDVRSSQ
The following text describes a protein:
Function:
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.
Subcellular Localization:
Nucleus.
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKGSRRRSSWPERTSPALASC
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.
Subcellular Localization:
Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin (By similarity). Colocalized with SIRT2 at mitotic foci. Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress-dependent manner.
Domain:
Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity.
Sequence:
MARGRKMCKPRAVEAAAAAVAATAPGPEMVEQRGPGRPRSDGENVFAGQSKIYAYMSPNKCSAMRSPLQEENSVAHHEVKCPGKPLAGIYRKREEKRNTGNVIRSAVKSDEQKSKDTRRGPLAPFPNQKSEAAEPPKTPPPSCDSTNVAVAKQALKKSLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKKNELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYVQDPSTGCYMYYFQYLSKTYCVDATQETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAYPWLKH
The following text describes a protein:
Function:
Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localized exclusively in cytoplasmic inclusion bodies under protein folding stress conditions.
Sequence:
MSLRSWFRGSGTTTPKSSAGPSRATTPPSGVQGTVMTAEQQELADLSDAMQAMAHIMNDDPESAEAHLRQRKDPSSFHLLGLGVSIFMRSILGFEKDVMAEASKCIADCETRSWNDKVKGERREPATDGRLFPNGSEFAIVYAQALLMNAVVSVLHESLTDALKAFYKLRKAMAVMSSISAAEEKIMKEQGASSARGNPFEQASTASGSGNLAAEDEDSDLEFVDADEKVSPEAPIHVTYDGHTSTKDSTSQPATDAATLEGKLQALEIPDDSDTKSHLSKSAVESQVPSLSASRAPSPGPPPQLTDAASDGSLFTHPIDIFIHSAINMCYGSLMLVLSMVPPAFSRLLGIIGFRGDRDKGLHMLWQSAAHPNMNGAVAGLLLLGYYHGLLAFADVLPSERDVAELAEPDEIVGYPRGRCIELLRVMRERYPASGLWRMEQARVLIGEKKLKEGIEMLEKCGDAKMRQVTALSTFELAVSSICYLDWPRMHSSFVRMVELNDWSHALYYFIAGCAHLEMYRDAVHELGGLSELSEDGSESEKEVKAGDVKVTATKDRLDVEDIRKKELISNARKYKKSAETLFRKAPTTAGRKRFMARQMPFEVFVMRKVAKWEERATALKLDLADAIGPSPAAEMIYLWNGGKRMNLELIEKAMTILEWDRCTSSATVAKVKEEHDEVAIHGVGQAALLRHAGRGDEAKGILLDISAYDRATCKGGNKDDYILASATYELAMLAWDDVCRPERWPTDADEVEEFRRKKTEECYTLLETVAKWETYVLDARFGMRVQTGLDTVRWLSKKKGWTL
The following text describes a protein:
Function:
May be involved in the degradation process of some misfolded endoplasmic reticulum (ER) luminal proteins. Its precise role is however unclear and its inability to complement der1 mutations, suggests either that it is not involved in degradation process of misfolded proteins, or that it participates in the destruction of specific misfolded ER luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAGPRNVRTLHGNGGRNNDVMGPKEFWLNIPPITRTLFTLAIVMTIVGRLNLINPWYFIYVWNLTFKKVQIWRLLTSCVMLSSRAMPALMELYSIYDRSSQLERGHFGPGLSNRRGPMVTVDYAYYLCFCILAITTATTIIYGSYYPVVLTSGFISCITYTWSIDNANVQIMFYGLIPVWGKYFPLIQLFISFVFNEGDFVISLIGFTTGYLYTCLDTHTLGPIWGMISRKADPTYGISPNGKFSTPWWFTSLYARITGAHNETATFNNNFANVPSSQRETRTFSGRGQRLGTAPATLSQTSGTDSGRASGSQLRSGPSNLNQFQGRGQRVGQTNSPSDSQ
The following text describes a protein:
Function:
Transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.).
Miscellaneous:
MISCELLANEOUS: Present with 521 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTNDIKEIQTIQPGLSEIKEIKGELANVKKRKRRSKKINKLTDGQIRINHVSSEKKRRELERAIFDELVAVVPDLQPQESRSELIIYLKSLSYLSWLYERNEKLRKQIIAKHEAKTGSSSSSDPVQEQNGNIRDLVPKELIWELGDGQSGQ
The following text describes a protein:
Function:
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Miscellaneous:
MISCELLANEOUS: AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MRAPLLPPAPVVLSLLILGSGHYAAGLDLNDTYSGKREPFSGDHSADGFEVTSRSEMSSGSEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENTSDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKKLRQENGNVHAIA
The following text describes a protein:
Function:
Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.
Subcellular Localization:
Membrane raft. Note=Recruited to membrane rafts and immunological synapse after TCR stimulation.
Sequence:
MEGEGVRNFKELRAKFQNLDAPPLPGPIKFPAGVSPKGDIGGTQSTQILANGKPLSSNHKQRTPYCSSSESQPLQPQKIKLAQKSEIPKCSNSPGPLGKSTVCSATSSQKASLLLEVTQSNVEIITKEKVMVANSFRNKLWNWEKVSSQKSEMSSALLLANYGSKAIHLEGQKGMGLTPEEPRKKLETKGAQTLPSQKHVVAPKILHNVSEDPSFVISQHIRKSWENPPPERSPASSPCQPIYECELASQAPEKQPDVRHHHLPKTKPLPSIDSLGPPPPKPSRPPIVNLQAFQRQPAAVPKTQGEVTVEEGSLSPERLFNAEFEEPHNYEATISYLRHSGNSINLCTAKEIADPTYEVGIEELQKPGKNFPYPEPSAKHEDKKMKEKQPCELKPKNTEKEPYSNHVFKVDACEGTPEKIQMTNVHTGRRNMLAGKQEAMIDIIQTNPCPEGPKLARHSQGHCGHLEVLESTKETPDLGVSKTSSISEEIYDDVEYSRKEVPKLNYSSSLASSSEENRELYEDVYKTKNNYPKIDLDGKEALKRLQQFFKKEKDRFKIKKTKSKENLSAFSILLPDLELKSQEVIIYDDVDLSEKESKDEDKLKMWKPKFLTPKEKKEKNGAEESESFSPRNFFKTKKQNLEKNRMKREEKLFRERFKYDKEIIVINTAVACSNNSRNGIFDLPISPGEELEVIDTTEQNLVICRNSKGKYGYVLIEHLDFKHQSWSP
The following text describes a protein:
Function:
Probable nucleotidyltransferase that catalyzes the formation of cyclic dinucleotide second messenger in response to some unknown stimulus.
Sequence:
MKMAAPTASKAASMGCNNKPAFPELDFRSGARVEELNKLIQEFTRHDQREYDDQRALEIHTAKDFIFSMLGMVQKLDQKLPVANEYLLLSGGVREGVVDLDLDELNVYARGTDYDMDFTLLVPALKLHDRNQPVTLDMRHSALCHSWLSLRLFDEGTISKWKDCCTIADHINGATNYFFSPTKVADWFYDSISIVLSEIQKKPQRGMPKVEKVEKNGTIISIILGVGSSRMLYDIVPVVSFKGWPAVAQSWLMENHFWDGKITEEEVISGFYLVPACSYKGKKDNEWRLSFARSEVQLKKCISGSLMQAYQACKAIIIKLLSRPKAISPYHLRSMMLWACDRLPVSYLAQEDYAAHFLLGLIDDLQHCLVNKMCPNYFIPQCNMLEHLSEETVMLHARKLSSVRSDPAEHLRTAIEHVKAANRLTLKLQRRGSTTSIPSPQSDGGDPNQPDDRLAKKLQQLVTENPGKSISVFINPDDVTRPHFRIDDKFF