lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MCSDVDDVFYGYHSPRSKCSAVQLAEMIKSFCVEVEREISELEGYSKLPNIDFAMTSKLARSIKARSILIGAKNVRGSCVYVIEACLVSDEETLSYAVLGLRNGFKRTKMRFETYLELWNRIAEKEKQLGEAKK
The following text describes a protein:
Function:
Folate-dependent protein involved in Fe/S cluster biogenesis. Functionally complements an E.coli mutant defective in ygfZ.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MNLLQSCKDMAMMMRIDSVSHITNTALLPCLYNGTVLRRRSLSLRKCGFRERKFQLRCVSASSDSLQFDFSPPPIDHDFLDTISVSGGKVSEDGVVESFDNDDEALDAFDNGVVVVDLSHFGRIRVSGDDRAHFLHNQTTANFESLYEGQGCDTVFVTPTARTIDIAHAWIMKNAILLTVSPTTCQSIIEMLNKYIFFADKVEIKDITKQTCLFALAGPKSNQIMSKLNLGDLIGQPYGRHQHYSFDGMPITVGVGSLISDEGFTMLMSPGGAVSVWKTLLAEGAIPMGSVAWEKLRITQGRPAPERELSKEFNVLEAGLWNSISLNKGCYKGQETIARLMTYDGIKQRLCGLNLSAPSEPGSTITVDGKKVGKLTSYTGGKNGSGHFGLGYIKKQAASIGNTVTVGEDISGIVSEVPYLARQHPPSANSSS
The following text describes a protein:
Function:
Glycosyltransferase involved in the biosynthesis of neomycin by mediating glycosylation of ribostamycin with UDP-GlcNAc as a sugar donor to generate 2'''-acetyl-6'''-hydroxyneomycin C.
Sequence:
MAEAPAGRALFEIYDEGFDSPSWGGVETALWHLSRSLREAGTEAEFYRSSEGADLDALAARVERDRVDAVFPLVESDLFEGAAWRRLPALHARTVRVWHDVSRLSADLSAPPPCPVHARVPALPGAPVAEGCPARGAHPEGPMREVFLGEWPWTRCFPRRSVIPWAADHVPAKDLCDPSGPVVLQLGKIDTVDAERCLRRLTGAGVALRVVFATWSRRGREARELVRAHQGAGRRVEVLDAYDIRTDWERVFGGASLFLLPSVFHETYNFAAAEAVQLGVPVAALGEGGNLPRFASLTAPTPDALVDRLLAGGGAVAPRPRPAAGWRDVAARYAEVIREHPAAGAGPAVPAGAGEGRGGREEEHGG
The following text describes a protein:
Function:
Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including tobramycin and netilmicin and to a lesser extent to gentamicin and amikacin.
Sequence:
MDSSPLVRPVETTDSASWLSMRCELWPDGTCQEHQSEIAEFLSGKVARPAAVLIAVAPDGEALGFAELSIRPYAEECYSGNVAFLEGWYVVPSARRQGVGVALVKAAEHWARGRGCTEFASDTQLTNSASTSAHLAAGFTEVAQVRCFRKPL
The following text describes a protein:
Function:
Catalyzes the hydrolysis of a range of N-terminal amino acids.
Subcellular Localization:
Secreted.
Sequence:
MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFKAKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTLSSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYEKAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLKLKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARVLKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASELYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPETEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDIFEDIK
The following text describes a protein:
Function:
Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) (By similarity).
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Cytoplasm.
Sequence:
METRAFWTTLLLVLVAGSSCKAQEFVGLSPSQCMVPANVRVDCGYPTVTSEQCNNRGCCFDSSIPNVPWCFKPLQETECTF
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Srp9 together with srp14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of srp9 and srp14 is required for SRP RNA binding (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MYIEDWDEFYDKSEQLYRTDPKRTRFSFKFRHVEGKVVLKVTNDTVNLKFQTDKENDFKRIDQINSLFFRLTTEQ
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MPTPWNKPESDEESPSAIAEPIYEGNVAPLQFDRILNFSEIDQKSYARNVRDRHRDRDVVASSKVDSTDIDVFCEENVNVYNHDTTDQPSDYDIEKELRKSLIDERLLNNLQKVKVERLNAVQRKSIRTVRDGVGLMVEAPTGIGKTYAFLIPAIERAMDERRKCKTVATKPSPFVLIMANTGTLVKQLFGRCELILGLKCMDGVNPIHDIKVDMLVAEHRFTADSCDIVFCTMGKLKATVESGDVLLDNLKMMILDEADKMIDTAAFGMDVEWILDQMKEEVVRELQSCFFSATFQRDRDAAITLTPLQMKMFGGKPWKLVHCPAMPGYITQHVIRLDRPGRDLTSHTWIKKMNIIRGLINEDLKTTDCKKEGPYKETIAIFCETIQRVAQVAMALRLLGYNFRPLCRTITKSQQEVTINDLEFKRIHGIVCTNIMSRGIDVSSIKHTIIMEMSSDFDTYKHRIGRVGRDGFGGKATVLIDHDTLMNPRSAQIVDALYVFMDQCQQPAPQWLKEWFERRHADEQYY
The following text describes a protein:
Function:
Involved in the biodegradation of 2-Nitroimidazole (2NI) which is a natural antibiotic and an analog of the synthetic nitroimidazoles used for treatment of tuberculosis, Chagas disease (also called American Trypanosomiasis) and cancer. Catalyzes the hydrolytic denitration of 2NI to produce imidazol-2-one and nitrite. It is also active against the 2NI synthetic derivative benznidazole. NnhA confers drug resistance to 2NI.
Sequence:
MTTVDKRPSSRGYGDWRLSDIPQYKDGISTYEFVRATHEADYRTHQAEPVAGRTFGFNGIGRLTEVALHMPTKYTLHDQSSQYKESPSFFQGLMGVPDRGPVDLAAFQRETEELATAFENNGIKVHWVDYPEEPANPYGPLMGHVFLSWGSIWRGGSVISRFGFLPGMVGVSEYLAKWAWNTLNIPPLVAITEGAMEPGACNMIADEVLVTCLSASYDQRGTDQLVAAISKTSGTEEFHNLQLRPAVEGFFNKATGACAHPDININAIDVGKLVVSPAALDWDARTWLYDNNFELIEADPDEQREFLAPCNVLLLEPGKVIAHADCHKTNQKIRDAGVEVIEVTGTEIRKACGGIKCRVMQINREPGPTLADVRNRVWR
The following text describes a protein:
Function:
Promotes the phosphorylation of AKT family members.
Subcellular Localization:
Cytoplasm. Note=Colocalizes with BTBD10 in filamentous structures.
Sequence:
MNVHQGSDGDWSLQPELSCLGDEALAATQEKEGSSLVSSGLHSVTYPLAARSEDLALDYASQPASLPHPHIMPLPEDNKGSCFQSGSKRSHEPFIVPERFGNSGLGFGGGAHSQAPEKVTLLVDGTRFVVNPQIFTAHPDTMLGRMFGPGREYNFTRPNEKGEYVIAEGISATVFRTVLDYYKTGIINCPDGISIPDLRDTCDYLCINFDFNTIRCQDLSALLHELSNDGAHKQFDHYLEELILPIMVGCAKKGERECHIVVLTDEDSVDWDEDHPPPMGEEYSQILYSSKLYRFFKYIENRDVAKTVLKERGLKNIRIGIEGYPTCKEKIKRRPGGRSEVIYNYVQRPFIQMSWEKEEGKSRHVDFQCVRSKSLTNLVAAGEDVLEDQEIIMHHPPQVDELDRLNAPLSQMAPNDFQD
The following text describes a protein:
Function:
An RNA-guided ssDNA endonuclease that may play a role in defense against invading mobile genetic elements. Uses short 5'-OH-ssRNA sequences as guides (gRNA) to bind complementary target DNA (tDNA) or target RNA resulting in target cleavage. The cleavage site is 10 nucleotides (nt) downstream of the target residue base-paired with the 5'-end of the gRNA. Reaction rates are fastest on 5'-OH-gRNA:tDNA followed by 5'-OH-gRNA:target RNA. gRNA between 17-21 nt supports equivalent rates of cleavage, has no preferred 5'-nt. Has weak activity on tDNA with 5'-phospho-gRNA, yielding products 1-2 nt longer. Unlike other characterized prokaryotic Ago proteins symmetric mismatches centered around the cleavage site reduce cleavage efficiency.
Miscellaneous:
MISCELLANEOUS: Unlike most prokaryotic argonautes, this is encoded in a CRISPR-cas subtype III-B locus.
Subcellular Localization:
Cytoplasm.
Domain:
Has 4 domains (N-terminal, PAZ, Mid and PIWI). The N-terminal and PAZ domains are joined by linker L1, the PAZ and Mid domains are joined by linker L2. The domains assemble in 2 lobes; the PAZ lobe consists of the N-terminal, L1, PAZ and L2 domains, while the PIWI lobe has the Mid and PIWI domains. The PIWI domain assumes an RNase H fold and has the catalytic residues. Compared to orthologs, the N-terminal domain has a different secondary structure and position. The 5'-end of the gRNA is anchored between the MID and PIWI domains while the 3'-end is in the PAZ domain. In the gRNA:tDNA complex the 5'-end of gRNA remains anchored in the Mid domain and is unpaired with tDNA, while the 3'-end of the gRNA is released from the PAZ domain. Upon release of the 3'-end of the gRNA from the PAZ domain during nucleic acid duplex formation, conformational changes allow Glu-482 to move to complete the active site. An N-lobe rearrangement allows a unique, straight orientation of the hybrid helix not seen in other Ago ternary complexes.
Sequence:
MYLNLYKIDIPKKIKRLYFYNPDMEPKLFARNLSRVNNFKFQDSNDLVWIEIPDIDFQITPKNVFQYKVEKEEIIKEEEDKKLFVKTLYKYIKKLFLDNDFYFKKGNNFISNSEVFSLDSNENVNAHLTYKIKIHNISNEYYLSILPKFTFLSKEPALESAIKSGYLYNIKSGKSFPYISGLDGILKIDIGNNQIVEVAYPENYLFNFTTRDAEKYGFSKEVHEIYKNKVFEGFKKIPKTLGFLNKITNLNENYQLKDGYKIFINVIYKFKNGESRYAKDVFKYSFYKNEQPLKAIFFFSSKKQFFEVQKSLKELFHNKHSVFYRAAAELGFSKVEFLRDSKTKSSAFLYNPEEFTVKNTEFINQIEDNVMAIVLLDKYIGNIDPLVRNFPDNLILQPILKEKLEDIKPFIIKSYVYKMGNFIPECKPFILKKMEDKEKNLYIGIDLSHDTYARKTNLCIAAVDNTGDILYIGKHKNLELNEKMNLDILEKEYIKAFEKYIEKFNVSPENVFILRDGRFIEDIEIIKNFISYNDTKYTLVEVNKNTNINSYDDLKEWIIKLDENTYIYYPKTFLNQKGVEVKILENNTDYTIEEIIEQIYLLTRVAHSTPYTNYKLPYPLHIANKVALTDYEWKLYIPY
The following text describes a protein:
Function:
May play a role in responding to changes in chemoattractant levels.
Sequence:
MEEDKDSDTLQILNDIINNEPNLEIYVKSKNNNYISSRELPTQDSSTKTSNITTPNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTPTSLNSSWKSVVPKRKIDTSSGAILNNNNNVGSPNNQSTSQTNHQQPPPQQLQQQQSLSSTSTPSISPPMLSPSRRNVTSPNLTRSDPTVPITNSRPTSPLTPPLSPQFQLNNLNFDDNNDHSTTTTNNNNNNNNNNSNNNNNNNRPKLMRENSINKRSSLQTLPVSSSSSSSAEDEILIKVWLPMEYTGQLYKVRKFSGGSSTLKVSSMLNSQLSPMYQSPKNKLFLNNEEKPIPSHLTLKDLSLSKYDILYLRREPEYELIIPSSPQCGSLVMDKDIKIDDMLIKIEHWLKDILDHAPHSTSQQQQQQLQQQPILHVDKHEYFTSLEDQQLMSGHITNSSQYTLLKKLSVPTSNSRQTGKMSRGYYLRLYDQKPISNYGIKIKDTLIFKKKILNRGLSIDDAEGGIEITVLYSPLSMLPTTSDLDFEKELKENQQQLNNNNNNNNNNNNNNNNNNNNNNNNITTTTTTTTSSLINQTNEILLPNLIKIDNTSLLQDIKNEKKKRKSKRTPSSVGLPFNIIHKTHVDFEYKWSGTSVEDTFEFKEKLGQGGYGAVFKVLHRETNFPLAIKVLSITPTRIKDIEKEIDLLKKCRCPNVLSYYGSISSKLTELWILMDHCAVGSINDMMKICCDTLDEEQIAVVTLNVLNGLGYLHSKGIVHLDVKAANILLTEDKQIKIADFGVSQQLQTEYGQANVYIGSPLYMAPEVILKAPYNSKADIWSLGITLIELAEGRPPNRGLRSMNQLVEIPNMPPPKLSNPKDWSPCFNNFLATCLVKDPVQRPSVIDLLSHDFIKNAKTTEVLSNLVKQTLSSRQSI
The following text describes a protein:
Function:
Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors.
Sequence:
MGNAPSNSSEDEAAAAGGEGWSPHQDWAADSGTTPGPGPAAAVLPSAAALLEPARLREAAAALRPAPPCESLVSRHHGALLRWLEERLGRGEESVTLEQFRELLEARGAGCSGEQFEEAFAQFDAEGDGTVDAENMLEALKNSSGANLQGELSHVIRQLQACSLVPGFIDIFSESKEGLGIHSSMILRFLHRNRISSMVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEKESPGDLARSPEMDKLKSVTKCYAYIETSSNPADIYRMTNGETSSYWQSDGSARSHWIRLKMKPDVVLRHLSIAVAATDQSYMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDTRIHGLRAVGFQRVKKSGVSVSDASAIWYWSLLTSLVTASMETNPAFVQTVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAFALARGSIAKVMSSLCTITDHLDTQYDASSLISSMASVRQNLLLKYGKPLQLTLQACDVKGKEDKSGPENLLVEPWTRDGFLTETGKTRASTIFSTGSDSAFQVTQIRIMVRRGGIGAQCGLVFAYNSPSNKFHAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGWFELEEEWDEADVKLQQCRVAKFLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQSILYAHCRRDTENIHGATLLLRTLQFIQQLSHDLMQQKESGLKHKSFLDFAGLDLQIFWKFYSKLKQNRREECICAQTLLLKLLQSCFSVLQGDPQAASEEEKPTAQRSEGIQAAKELYTHLCNVVDKPNGNSMPMEILKQEVRNTLLNGAAIFFPDRQTRRSQLFTMMKSVTEHERKQSLQLTFHSLCTYFSDKDPGGLLLLPEKSDLATMNTSEVLAVMNTLLSVAARECELLMLNRSHGAVGSVLFSLFWSVQGSLLSWCFLQLKSTDAAAKELAMDLIEKYVGQFLASMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDVSHCTLLREFSTLTELLKKLCSDPEGGLSKLDVETWQQEQPVVLHTWTKESTHNYENNCHEVSVFISPGATYFEVEFDERCETEKRYDYLEFTDSRGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHSDSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVHQLGSNMAVSQAKLTSVLNSPLWKPVFRHQICPELELEASWPTHPHKDGKEVKNIPDDPCRHFLLDFAQSEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQKYVNSGGKIALTEEFSQVYSLADGIRIWMLEMKQKSLLSLGNDSEEKRGLEAAEVNPESLAKECIQKSLLLLKFLPMSKSSKENCDKLETVDETDHLQPLDRRQRTSSVVEEHFQGSASPTEAATPAAGDRSPALEIQPKLLPSSGPCVAEVSTAEEPSPPSTPTRRPPFTRGRLRLLSFRSMEETRPVPTVKEKYPVLKDVMDFIKDQSLSHESVVKVLSLRKAQGQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLTCQKDFTNYFGHLEGCGADLHREIRDTYYQLVLFLVKAIKRFSSINDRSLLPALSCVQTALLHLLDMGWEPSDLAFFVDIQLPDLLMNMSQENISVHDSVISQWSEEDELADAKQNSEWMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVDISCDGCDEIAPWHRYRCLQCSDMDLCKTCFLGGVKPEGHGDDHEMVNMEFTCDHCQGLIIGRRMNCNVCDDFDLCYGCYTAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTSTEQVDGEQLDPQARTNAATLRSQCMQLVGDCLMKAHQGKGLKALALLGVLPDGDSTSENQALPVTVSFQASEEQADAGLLVPCNGKRAADTEVRPLDYKQKKKAGEDLSIVKDPSCQTQVSDAPASAHVPPGLPDAEHPEVSAQVLVEEKAITPNPEQVFAECSQKRILGLLAAMLPPIKSGPTVPLIDLEHVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLQPAEVDAAVMKVLSAKHNLRVGLDWACSMAEILRSLNNAPLWRDVIATFTDHCIKQLPFQLKHTNIFTLLVLVGFPQVLCVGTRCVYMDNANEPHNVIILKHFTEKNRAVIVDVKTRKRKTVKDYQLVQKGGGQECGTSQSQLSQYSQHFAFIASHLLQTSMDSHCPEAVEATWVLSLALKGLYKTLKAHGFEETHATFLQTDLLKLLVKKCSKGTGFSKTWLLRDLEILSIMLYSSKKEINTLAEHGDLELDERGDQEEELDRPVSSPGEAEQKKLDPLENLDEPTRICFLMAHDALNAPLHILRAIYELQMKKTDSFFLEVQKRFDGDELTTDERIRSLAQRWQPSRSLRLEEQSAKAVDTDMIILPCLSRPARSDQATPESNPVTQKLISSTESELQQSYAKQRRSKSAALLHKELNCKSKRAIRDYLFRVNEATSVLYARHVLASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLGTMALAACQFMEEPGMEVQVRESKHSYNNNTSFEDKVHIPGAIYLSIKFDPQRNTEEGCDELAMSSSSDFQQDRHNFSGSQQKWKDFELPGDTLYYRFTSDMSNTEWGYRFTVTAGHLGRFQTGFEILKQMLSEERVVPHLALGKIWEWLVGVACRQTGHQRLKAIHLLLRIVQCCSHSDLCDLGLLKPLWQLFTHMEYGLFEDVTQPGILLPLHRALTELFFVTENRAQELGLLQEYLLALTTEDHLLRCAAQALQNIAAISLAINYPNKATRLWNVEC
The following text describes a protein:
Function:
Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKHKTKTTGKGRLDRFYYLAKEQGFRSRAAFKLVQLDRKYHFLSSANSVLDLCAAPGGWMQVAAKHMPVGSLIVGVDLVPIRAIRGAHTLVQDITTSQCRAAIKKLLKEQGHNVIQVVLHDGSPNVGGAWTSEATSQSALVLDSLKLATEFLAPGGTFVSKVFRSQDYTALLYAFKQLFEKVEVTKPVASRATSAEIYVVGLKYKAPAKIDPRLLDHRHLFQGVEEPSKVIDVLRASKQKRHREGYEEGVTTLRKEVPVHDFVWTEKPLELLGTITSISFTSPDDKSINEHPLTTEEVKTLCEDLRVIGKQDFKLLLKWRLKLRDAIKVQGEDGEKTKPEEEDTAPKVDEDQKLLAEMEELKERMEANKKRAKKLAAKKKAKLKARTATGMQVDVMEDKDMYGDEDLFALSVIKAKKDLARVEGAGSSGEDNSDVYMSDDEDMLNNVPSKEDDSDLDSEEERSRYDAELDKALEQAYERYVKDTDGSSKRRRRARLNNDDQDADLWEEGEEPETVVRKGRKVTEEDEDGNPLLVPLVEKAKPSKEQLSQQWFSQDIFSTFKEPEDDNGVSTTEKKRKREETNGVVKSTNGVAEEDDEPRLAADDDKDNDFEVVPVEASGSSDSSSDDDSDLDDNAKAETLAYAKKMLTKKSRESILDEAYNRYTFDDDNLPRWFADDEKKHSVVQKPVTKEDIEAFKAQFKAINARPVKKVAEAKARKKRRVVKKMEQVRQKATAIADQEDINSTSKKKMMERLYNKANAVAKKPKREIVVAKKGVGSKGGAGRVVVDRRMKKDQRARGSGKAGKKGGSKAPAGKGKGGKGGAKGGISGGKKSKRGPKPQKG
The following text describes a protein:
Function:
This protein binds directly to 23S ribosomal RNA.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAACATHSSLMLAYAAASTRSQDLTPTPSLFSFASSRPNHLSFPLLLLGGSRDRRCAAIDRASNHKFIVSAVAAEADLDTEEDLEQTATAVLDPPKPKKGKAALVLKRDRTRSKRFLEIQKLRETKKEYDVNTAISLLKQTANTRFVESVEAHFRLNIDPKYNDQQLRATVSLPKGTGQTVIVAVLAQGEKVDEAKSAGADIVGSDDLIEQIKGGFMEFDKLIASPDMMVKVAGLGKILGPRGLMPNPKAGTVTANIPQAIEEFKKGKVEFRADKTGIVHIPFGKVNFTEEDLLINFLAAVKSVETNKPKGAKGVYWKSAHICSSMGPSIKLNIREMIDFKPPTAN
The following text describes a protein:
Function:
Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. The heterodimer formed with CLEC6A is active against fungal infection. Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MGLEKPQSKLEGGMHPQLIPSVIAVVFILLLSVCFIASCLVTHHNFSRCKRGTGVHKLEHHAKLKCIKEKSELKSAEGSTWNCCPIDWRAFQSNCYFPLTDNKTWAESERNCSGMGAHLMTISTEAEQNFIIQFLDRRLSYFLGLRDENAKGQWRWVDQTPFNPRRVFWHKNEPDNSQGENCVVLVYNQDKWAWNDVPCNFEASRICKIPGTTLN
The following text describes a protein:
Function:
Transcription factor that controls part of the HOG1-mediated osmostress responses. Binds to the DNA sequence 5'-ACTACTA[TA](4)TAG-3'. Does not appear to function in the MPK1 pathway.
Subcellular Localization:
Nucleus.
Sequence:
MGRRKIEIEPIKDDRNRTVTFIKRKAGLFKKAHELSVLCQVDIAVIILGSNNTFYEYSSVDMSNLLNVHQNNTDLPHNIIEPSDYGDYVKKPRVVLNERKRRRRRATVLQPASHSGSCTVSSQDSSSVQNNGNLSAPLASNDAGNAGVSTPLVHCHGAISRSGSNHSDCARNSADYQMLQGGLNSGGSFHANDYKESVDQQHVANEAIHRNFMNKRIRPDTHLLLSESNHSNYHNFYPSPYENLPKPSLPASLVGNIPSFQSQFVQVIPANSNPMGKGFNGTGDSESFEAKQKIHPTVAISNTLEGPAPVQAMVHHLHQLNSNRGKLSGKPYLKLNIPKATNDACQRSPAMYSGTASPKTDVQATPNQMLASNMSSPLSRSKFLGFKNNDMDDLYHNGRCGSTYVNNKTFFLKPPIGRPPKFPKSPSSSIVVFPSSVASSTLKSTSSTNSPD
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MRSQQQQQGQGSPPPSASSCKRPRTAMKPLPPAHLAALRGRVWEARHLRTGLRVAIKILCHAKMRAAKLKPEREPRVMRLLSLGRHPHVARFYEAIRPPAAGDNQYTYIVMELAESGELHDHVAVRERLPEAEARRIFQQLAAAVAYCHRNRVAHRDLKMENVLLDAEGSVKIADFGFSKLWSPGKMQSRSLGSPEYAAPELLEGRSYRGPEVDVWSCGVILYAMLCGRYPFDGADMSDLARNIRRGEFRLPSWVSDDARDLISSMLIVRPEKRATLAEVTAHRWLQPDMPPHLAMPPPDATAAAARQGVNAATVELLVTRHGFERTSLLQSIRLDDGSEEAVAYQLVLSKQHDAATLYQLSMPPPPPPHGRHQWALDGGELVLRECPRETMRRVAKALGELGVRILFYHSHRHRMVCAHVRAAGGGGVPTAAIIHSFIRRHKDCGGSSSSSGAATATATDDDTAAVESLSAAAVFFEIQLLKAGEGNGNSNSQQHQYVLHLKRTSGPQIPYLRVCAQLASKLKSNPY
The following text describes a protein:
Function:
Serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex. May play a role in the regulation of synaptic vesicle exocytosis.
Sequence:
MAVTYLLRRYKPATISSVLSFSTKCFVGRTSSLSVPTEAPPVPKKIPFAISSHGITRQDPFHWMKNTDDTDFVDFLKRENSYSQAFMADTETLRRDLFSEMKTRIPEEIFTPPERWGQWLYRQYIPKGKEYPLLCRRLEKGKTNWLSGLFRGEEEEVVLDWNQIAEQFGYVHVGVCRVSPDHNYLAYTVDPEGDGITLFYTVTDENQRPHRVVVTNVESDGRDDAVVFTERDSSFCVDITTTKDGKFVTINSNSRTSSEVYIVNADKPMAGLQRTRERVPGVQCFLEHHNGFFYILTNSPSNAISEWSGEGYYLTRCLVEEIEASDWQTVFRPDDDVVIQDMDMFNDYLVLYLNKKGLPMLCSIDMPIKANTKHMDDLVPWYFPLPVDSCSVAPGSNHDFQSSIYRVVLSSPVIPDTIVDYDVSRRLFSIVQQEGGVVDNSDSSKPWYTADRSTENNGQLNDRTSEGEDGQLDSRMPKWEDLSDTYVCERQEVSSHDGVEVPLTILYSREAWKKSESPGMLIGYGAYGEVLDKSWCTNRLSMLDRGWVIAFADVRGGGSGEFSWHKSGTRSLKQNSIQDFIYSAKYLVEKGYVHRHHLAAVGYSAGAILPAAAMNMHPSLFQAVILKVPFVDVLNTLSDPNLPLTLLDHEEFGNPDNQTDFGSILSYSPYDKIRKDVCYPSMLVTTSFHDSRVGVWEGAKWVAKIRDSTCHDCSRAVILKTNMNGGHFGEGGRYAQCEETAFDYAFLLKVMGHHNNR
The following text describes a protein:
Function:
May function as histone H3 lysine demethylase and be involved in regulation of gene expression.
Subcellular Localization:
Nucleus.
Sequence:
MATLIAKQRPLSSQNAPRMRNPSKVFRKRNFILNNDEEKHGKDNAASLLNVTEFPNKKPKLCSDTVVPRGRRTMEEQVGVVIRKGVPEDARLSGALGERIKTAQKPKKNMITSHQRTKTIATGKESDDSRSRMHHRSAKKKEPSFISWDDFISDDEEEEECKEEEDEERCSGPLTKSQMPLDEEYCPGPLTRSQMPLDEALNSLRNSEKFWRTSKQEKVLKNGPMRNKRNDKVKDEPLECRDRLKLSTSTKSILLSGNPQRKGMPDKVNLEQSLGTSSKKMAQKGDNTMNKVECGTEEKWGACKKKPSLSKVGKKMPGTQEIEGSRNKRVPAKLNGEKCLGTSSKKKIPKTMDKVDESEDKWDVCKEKPSLSKDGKKTLENHEKDAENKRISVRRVAASFKRYGHDYYVGEWEDDTEGYEVLPISNGHHIPSNTRSQRIDVSHDLKPNNSPKDIIKNSEKLSACSSSPSSSSSSGSTISRSGIDRSTNMKVNFQPPKCHQCRRSDRRTVVPCMKCKEKLYCIQCIREWYPELEEEEVSEVCPYCRGKCNCNLCLHSSGTLKTSRRDLTDREKIEHLHYLIIELLPFLKEIHQEQIQEIEMESSIRGVSSSSVEIKQSLYQNDERVYCNNCSTSIIDLHRSCPNCSYELCLSCCQELREGRFPGNSDEAVFQYLDRGYDYMHGGDLLHENFHNMKISQDQKKPITWIANYDGNIMCAPVEMGGCGNCILDLKHLLPKNWISTLQAKAERILIQCNFAQIISQPICTTDDPELLHKAASRVGSDDNCLYSPTAKDTMKDDALLHFRRHWAKGEPVIVRDVLEHTSGLSWEPMVMWRALCESTDSKILTSMSEVKAIDCLAGCQVEINTRKFFKGYTEGRTYKNLWPEMLKLKDWPPSDKFEDLLPRHCDEFISALPFQEYTDPRIGILNLAVKLPTGVLKPDLGPKTYIAYGMTKELGRGDSVTKLHCDMSDAINILTHTAEMAVSDEQQSAIESLKQKHRAQDERECLEHDGNEYPMKISSGIRREEKTPETTGGALWDIFRREDVPKLKEYLLKHAKEFRHTYCCPVDQVFHPIHDQTFYLTLEHKRKLKEEFGIEPWTFEQRLGEAVFIPAGCPHQVRNLKSCTKVAADFVSPENIQECLRLTAEFRKLPRGHKVREDKLEIKKMIIHAINQVVTDLEQLTYIV
The following text describes a protein:
Function:
Synthesis and degradation of fructose 2,6-bisphosphate.
Sequence:
PPGHSGPPPSSRVCVARWPEGGDLLTPKALWPLAALEGEEREEEEEEEEKGPRLSAPHTDSPTGGAGPAGAHSLAPSLPRSLALWLPRSLPGSLARSPARVRRPTSLTSSLPTATSGGPHSRARGQPGRAARHVPGDGGAHADAAAEDLDPPQQRQPSAAAQGLIHPPVHQLPNDGDHGGAACPGQDLYLYKAHQVPQLDWNPNQRQCALAALKDVHDYLGHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICHDPDIIEENITQVKLSSPDYKDCDREKVVEDFLKRIECYEMNYQPIDEELDSHLSYIKIFDVGTRYLVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDSGLSPRGKQYAYALANFIQAQSISSLKVWTSHMKRTIQTAEALRVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSAEELPYLKCPLHTVLKLTPVAYGCKVESIYLNIEAVNTHREKPEELPPCSSGQPPTNPTALLGRPE
The following text describes a protein:
Function:
Hydrolyzes N-substituted formamides, but not amides. N-benzylformamide is the preferred substrate, while N-butylformamide is hydrolyzed at a much lower rate. Has very low activity towards allylformamide, N-(2-cyclohex-1-enylethyl)formamide and N-(alpha-methylbenzyl)formamide.
Sequence:
MTQMRDLMIINANVRTVDARNSCAQAVLVSGGRIAIVGTETEVRGAAAPDAEVLDVSGKTVVPGFIDAHNHLSVAAFAPDSVDCSTPPLATLDEVLEVIERHCRNIPPGQWVRGINFHASHIREQRNPTRYELDEVAPNNPFFLIDASCHAGFANSAALDLVGIGAHTPEPWGGEIERDLSGKPTGTLLEAAANLLHSASWNDYAERDWDRAVELLHSKMNDYLAVGLTGVGDAMVTAKSAELYRRADAAGKMPFTLQQLHGGDHFFSMQDLGRSDTVDRIMEPESYLLRGGAMKIFVDRAYPSPAIDQIHDGCKTHVGANFYSKSEVHDLAVRASKLGINLAIHGMGNCAIDIVLDAYEAVRRQSNADTVLRLEHAFIAETGQGQRMADLGIDLVANPGLAFGWGEVFNMWRGENQEHLKLFPVRSMLDAGVRVSLASDHPCGTYSPAEIMWTAVARETMAGAPLEPDEAVTADEALRMYTINPAHASGRGSEEGSIEAGKRANLLVLDRDPVDCATGELRELQVLRTYVDGVLRYERTGS
The following text describes a protein:
Function:
Involved in rRNA-processing and ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAPAESITKASYREVVNAFGLHEYGQMALFAGAAAAFAIRAGPAVQAKPAAWTAAILGLMGGFGSSYITTSSHEDEDVYYSTHLRGERLSDISGRTDHHQHAGDPARFAILSGEMVWRSKGWGKQRYTTIHGLDASRRWSSACIGTTCAQHLAHLTVELLLLLAGQNKRNKKRMSIYTQNFGFRQPFQVLVDGTFAQACLDSQIHVTERLPDLLGGPVQIFTTKCLYVELDAIGEDMHGAKVLLRNFKFRRCGHKPTIMAGKCVKNLIGPKNEHRFVVATQDNRLMRDLAAIPALPVITVLNNRPILLKPTVATEQAVAALTARKIGAPVPAAAAPLKTRPASSATSGAVRSSGPAGASAGATQPRHKKKKGPNPLSMKKKQPKGRDQQRGKRQADAGPTDAKRAKPA
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Miscellaneous:
MISCELLANEOUS: Present with 1510 molecules/cell in log phase SD medium; MISCELLANEOUS: During the reaction, ATP is used to activate the C2 atom of U34 by adenylation. After this, the persulfide sulfur on the catalytic cysteine is transferred to the C2 atom of the wobble base (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards the activated C2 atom on U34. Subsequently, a transient disulfide bond is formed between the two active site cysteine residues (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MLARYLNLIGRRSASPYRPQRLPAKFDNVIVAMSSGVDSSVAAALFAGEFPNTRGVYMQNWSESQSLDDPGKEPCYERDWRDVNRVAKHLNIRVDKVNFEQDYWIDVFEPMLRGYSEGSTPNPDIGCNKFVKFGKLREWLDEKYGTGNYWLVTGHYARVMQEMNGKGLFHLLRSIYRPKDQSYYLSQINSTVLSSLLLPIGHLTKPEVRDLAKYAGLPTAEKPDSQGICFVNNSQHGKFKNFLKHYLPSSPGDIITVDPQSGAKTTWGRHDGLWSYTIGQKVGISMPQADPNYQGTWFVSEKLRDTNEILIVRGRDNPALYSDTMRIENFSSLGPREDTINAFQNTGALTLQFRSLQVPVQIKSCKLNRSADNLDITIHLASKQRAITPGQSCCLYIDDRVLGSGPISHVNNNDTHA
The following text describes a protein:
Function:
Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.
Subcellular Localization:
Cytoplasm.
Sequence:
LSTNTILKFLTARKFNVQRAVDLYISHQETRRKENLLEIDPWNPHIRKELLSEKLTVLPTRDKDGSGILLFTARQHQPSLTNHSYVLQGLVVQLDAALESPETQKNGIVFIYDMTGSKFANFDYELNIKILKMLRGSYPARLKKVLIVTAPLWFKAPFKVLRVFILEKLRDRVHILNADELVTHLPLTSIPIQLGGYLRHNHQEWLTKCLLISSSQSSTSSLLLSSYHRHNNNNNNNNNNNNNNSNSSTSSSTNATAAKHFSTTTSSSTAVTSLKNDDLTVVNYDCGKNGLTAVELQKHFDTVGVHGLEAEYNIIRSDPVIGSIHKFKMKVNQGKNRYSDVVCLDRTRVPIQLRLSDDDDGRYVNNEDDDNDEDDDRSPYADFWQMVWEQKVMVVVMTTKLMERGRTKCGQYWPKDDSTIDTHNSLAVINCGSVTSGDLVTTTLLLQNVKTSESREIKHIHFLGWPDYGVPTSAESFLELMFYVRQVQATMCIINGCYGDGWNVAEPPIVVHCSAGIGRSGTYIAIDIMTQALKHSNKVNVMEVIRKIRSQRALSIQMSDQYAFCYKALLCYAKKVGLLR