lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.
Subcellular Localization:
Nucleus, nucleoplasm. Cytoplasm. Note=A small fraction is detected in the cytoplasm (By similarity). Excluded from the nucleolus where it is targeted upon CDKN2A overexpression. Localizes to the mitotic spindle during embryogenesis.
Sequence:
MEGAMAVRVTAAHTAEARAEAGREAGEGGVAAAAALSSGGFLGLPAPFSEEDEDDVHRCGRCQVEFTALEDFVQHKIQKTCHRAPQEALPTTPAATALLDQEVVPTAAEGGPDEPITVAHIVVEATSLAEDISHAPDLVGSGHIKEVIVAAEAEPGDVEMAEAPGSPNHQELGLLGEGEQAHVKLLVNKEGRYVCMLCHKTFKTGSILKAHMVTHSSRKDHECKLCGASFRTKGSLIRHHRRHTDERPYKCAKCGKSFRESGALTRHLKSLTPCTEKIRFSISKDTAVGKEEVPAGSSASTVGTVTSSVAGDPMETSPVIHLVTDAKGTVIHEVHVQMQELPLGMKALTPESPDSEELPCSSENSRENLLHQAMQNSGIVLERVAGEESALEPAPPSGSSPQCLGDGSPELPLLKVEQIETQVASEAATVPRTHPCPQCSETFPTAATLEAHKRGHIAPRPFTCTQCGKAFPKAYLLKKHQEVHVHERRFRCGDCGKLYKTIAHVRGHRRVHSDERPFPCPQCGKRYKTKNAQQVHFRTHLEEKPHVCQFCSRGFREKGSLVRHVRHHTGEKPFKCYKCGRGFAEHGTLNRHLRTKGGCLLEVEELLVSEESPSAAATVLAEDPHTVLVEFSSVVADTQEYIIEATADDTETSEATEIIEGTQTEVDSHIMKVVQQIVHQAGAGHQIIVQNVTMDQETALGSEATAADTITIATPESLTEQVAMTLASAISEGTVLTARAGPNSTEQATVTMVSSEDIEILEHGGELVIASPEGQLEVQTVIV
The following text describes a protein:
Function:
Processive glucosyltransferase involved in the biosynthesis of both the non-bilayer-prone alpha-monoglucosyldiacylglycerol and the bilayer-forming membrane lipid alpha-diglucosyldiacylglycerol. These are major components for maintaining the anionic lipid surface charge density, for balancing the bilayer to non-bilayer phase equilibria and for keeping a constant lipid bilayer spontaneous curvature (curvature packing stress). Catalyzes the transfer of a glucosyl residue from UDP-Glc to diacylglycerol (DAG) acceptor to form the corresponding alpha-glucosyl-DAG (1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol), which then acts as acceptor to give alpha-diglucosyl-DAG product (3-O-(alpha-D-glucopyranosyl-alpha-(1->2)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol). It can only use UDP-Glc as sugar donor.
Subcellular Localization:
Cell membrane.
Sequence:
MKVLLYSQKQSMLKKSGIGRAFYHQKRALEAVGIEYTTDPKDTYDLVHVNIAHSNKIKKFRKKYPVIVHGHSTVQDFRRSFAFWRVIAPFFYKHLQNIYGIADLIITPTRYSKFLIESMHVVKSPVVALSNGIDLDAYEYKQENVDAFRKHFDLEPNQKVVIGVGLLFERKGIHDFIEVARTMPNVTFIWFGNLSKLATTHFIRKRIKNKPKNMIMPGYVDGAVIKGAFSGADCVFFPSYEETEGIVVLEGLASKTPVVLRDIPVYYDWLFHKEHVLKGHNNFEFSKLIEKVLHEDQTEMIENGYKIVQDRSIEKIGEGLKQAYQEVIKIKR
The following text describes a protein:
Function:
D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
Sequence:
MKVVMTTKVDLASMNIREKLIENFGFKEDELLFDGNPVYQKDDVVILTTNQEMIYYDGLDRAIERQTGIKPEIIAFASRHSSKQKLPALTTHVTGNWGGALYGGKDESLAIAQPSAMKLALLKMNELNDLGWTVCYEATHHGPSELDVPSFFIEIGSSEEEWVNDRAGEIVAETIIYVLENYQNSKFKVAVGIGGGHYAPKQTKRALQTDLAFGHIAPKYAHPLSKELLLKAIERTAERVDAIYVDWKGSKGETRQMARAVAEELGLEFIRD
The following text describes a protein:
Function:
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
Subcellular Localization:
Cytoplasm.
Sequence:
MKNKVLKLKNNKIFDKKLATFLKNLDIFPNNWEFFEKAFIHASYINEHEDVSESYDRLEFLGDALIDFVVAKKLFELYPKYNEGLLTRTKIEIVKGENLNRIGMELKLGDFVKLSNGAELTENTVGDVLEALVGAIYEDMGMKKATEFVEKYIFERTFSEILKYDFFSLFQEQKLPEPRVRVSLTSNNLVLSIIELDGDIIWSQAIPNNKNYDDKSVLEHNAMASFTSFLKSSKGSHFFSDLKEKIENQKMCKKLAIKPKKN
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
MCACTFLFVDCTILLQSEIVVDNNPSKSVNTKEQIISITAEKTSATDARGSTSLESPKGSQEKANFLGKGGEQPYVYQTNVYAPQPQTVYSGGYINPSGQWEEYPYYVSMEGLHSASPSIMLSPGYANNPQMMYGAYSPVATVGEGQSYSPMHFPFSSPYYQPPASLSMGYSNSSTGMSQGDPMLQQEYFLPDGLLYSPTTVYHQPFESYNRDWSEPFQTNCEFLPQRQHNQAMLRDYLGKGMHHWFLECIDYACYLQQHGSMYNSGSYKARQQASKYGGITPNWGSAGRRFNNFDYNSSQQRVSMPFNIQNGALEFLNEQNRGPRAAKPKKQDRDNSLVDDKSEKTTQLIDSELYNCPDFATEYKDAIFFVIKSYTEDHVHRSIKYNVWASTASGNRKLDSAYRAAKQKEDHCRVFLFFSVNGSGQFCGVAEMIGPVDFDRSVDYWQQDKWSGQFPVKWHIIKDVPNTLLRHITLENNDNKPVTNSRDTQEVKLEYGLQMLSIFKNHEAETSIVEDFDFYEQREKALKENRRQQQPGSAESLKPTDAKAVGNSVTHIADSFSRSVQLKEIEKSDNKLTADGAISVNDAQTATVKAEESNANKTKGPVEESS
The following text describes a protein:
Function:
Transcriptional repressor of CCA1 and LHY, and positive regulator of LWD1 and LWD2 expression. Represses the expression of other clock proteins and master regulators of plant growth, development and response to abiotic stress. Involved in the positive and negative feedback loops of the circadian clock. Controls photoperiodic flowering response and temperature compensation. Expression of several members of the ARR-like family is controlled by circadian rhythm. APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes to repress their expression from noon until midnight. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock.
Miscellaneous:
MISCELLANEOUS: Regulated at the level of mRNA maturation and alternative splicing by SKIP. The expression of APRR9, APRR7, and APRR5 requires the presence of LWD1 and/or LWD2, indicating the existence of a positive feedback loop within the circadian clock.
Subcellular Localization:
Nucleus.
Sequence:
MNANEEGEGSRYPITDRKTGETKFDRVESRTEKHSEEEKTNGITMDVRNGSSGGLQIPLSQQTAATVCWERFLHVRTIRVLLVENDDCTRYIVTALLRNCSYEVVEASNGIQAWKVLEDLNNHIDIVLTEVIMPYLSGIGLLCKILNHKSRRNIPVIMMSSHDSMGLVFKCLSKGAVDFLVKPIRKNELKILWQHVWRRCQSSSGSGSESGTHQTQKSVKSKSIKKSDQDSGSSDENENGSIGLNASDGSSDGSGAQSSWTKKAVDVDDSPRAVSLWDRVDSTCAQVVHSNPEFPSNQLVAPPAEKETQEHDDKFEDVTMGRDLEISIRRNCDLALEPKDEPLSKTTGIMRQDNSFEKSSSKWKMKVGKGPLDLSSESPSSKQMHEDGGSSFKAMSSHLQDNREPEAPNTHLKTLDTNEASVKISEELMHVEHSSKRHRGTKDDGTLVRDDRNVLRRSEGSAFSRYNPASNANKISGGNLGSTSLQDNNSQDLIKKTEAAYDCHSNMNESLPHNHRSHVGSNNFDMSSTTENNAFTKPGAPKVSSAGSSSVKHSSFQPLPCDHHNNHASYNLVHVAERKKLPPQCGSSNVYNETIEGNNNTVNYSVNGSVSGSGHGSNGPYGSSNGMNAGGMNMGSDNGAGKNGNGDGSGSGSGSGSGNLADENKISQREAALTKFRQKRKERCFRKKVRYQSRKKLAEQRPRVRGQFVRKTAAATDDNDIKNIEDS
The following text describes a protein:
Function:
ATP-dependent 5'-3' DNA helicase. Thought to be involved in nucleotide excision repair (NER) of DNA (Probable).
Domain:
[4Fe-4S]-binding is required for protein stability and helicase activity.
Sequence:
MLKLRDWQEKLKDKVIEGLRNNFLVALNAPTGSGKTLFSLLVSLEVKPKVLFVVRTHNEFYPIYRDLTKIREKRNITFSFLVGKPSSCLYAEKGAESEDIPCKYCELKGSIVEVKTDDSPLSLVKKLKKDGLQDKFCPYYSLLNSLYKADVIALTYPYFFIDRYREFIDIDLREYMIVIDEAHNLDKVNELEERSLSEITIQMAIKQSKSEESRRILSKLLNQLREVVLPDEKYIKVENVPKLSKEELEILADDYEDIRKDSLKQGKVNKIHIGSILRFFSLLSIGSFIPFSYSKRLVIKNPEISYYLNLLNDNELSIILMSGTLPPREYMEKVWGIKRNMLYLDVEREIQKRVSGSYECYIGVDVTSKYDMRSDNMWKRYADYLLKIYFQAKANVLVVFPSYEIMDRVMSRISLPKYVESEDSSVEDLYSAISANNKVLIGSVGKGKLAEGIELRNNDRSLISDVVIVGIPYPPPDDYLKILAQRVSLKMNRENEEFLFKIPALVTIKQAIGRAIRDVNDKCNVWLLDKRFESLYWKKNLKCLNANKMKL
The following text describes a protein:
Function:
Key structural protein of the Golgi apparatus. The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon. Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks. However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA. Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane.
Subcellular Localization:
Golgi apparatus membrane; Lipid-anchor. Endoplasmic reticulum membrane. Golgi apparatus. Note=Detected in the intermediate Golgi, membrane-associated (By similarity). ER stress triggers its relocalization from Golgi to ER membrane.
Sequence:
MGSSQSVEIPGGGTEGYHVLRVQENSPGHRAGLEPFFDFIVSINGSRLNKDNDTLKDLLKANVEKPVKMLIYSSKTLELRETSVTPSNLWGGQGLLGVSIRFCSFDGANENVWHVLEVESNSPAALAGLRPHSDYIIGADTVMNESEDLFSLIETHEAKPLKLYVYNTDTDNCREVIITPNSAWGGEGSLGCGIGYGYLHRIPTRPFEEGKKISLPGQMAGTPITPLKDGFTEVQLSSVNPPSLSPPGTTGIEQSLTGLSISSTPPAVSSVLSTGVPTVPLLPPQVNQSLTSVPPMNPATTLPGLMPLPAGLPNLPNLNLNLPAPHIMPGVGLPELVNPGLPPLPSMPPRNLPGIAPLPLPSEFLPSFPLVPESSSAASSGELLSSLPPTSNAPSDPATTTAKADAASSLTVDVTPPTAKAPTTVEDRVGDSTPVSEKPVSAAVDANASESP
The following text describes a protein:
Function:
Involved in a root UV-B sensing pathway and in the protection against the hypersensitivity to very low-fluence-rate (VLF) UV-B. RSU1 and RUS2 are probably both negative modulators of the same UV-B perception pathway, which when overstimulated in the roots causes a block to postgermination development. Required for polar auxin transport by maintaining the proper levels of auxin transporters AUX1 (AC Q96247) and PIN proteins on the plasma membrane.
Miscellaneous:
MISCELLANEOUS: Several mutations in ASP2 (AC P46645), but not all, and any of the non-phosphorylated B6 vitamers can suppress the rus phenotype.
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MSCSYLLSGDASVVASRRWSDVSSRQRLFLPRQSLRQPSGSSFSRCVRLVANVNDHFSKQSLATRNCLASVFSADLGGSNGNNDNGNGGGGGGDGGGDNSDDSSFDLRYLCFLLLGLSCFFHFRLSAASAIAKDQNSDSNGDAVKETVWEVRGSKRKRLVPDFVKDEFVSEESAFELSSSLTPENLLAQCRNLLTQFLLPEGFPNSVTSDYLDYSLWRGVQGIASQISGVLATQSLLYAVGLGKGAIPTAAAINWVLKDGIGYLSKIMLSKYGRHFDVHPKGWRLFADLLENAAFGMEMLTPVFPQFFVMIGAAAGAGRSAAALIQAATRSCFNAGFASQRNFAEVIAKGEAQGMVSKSVGILLGIVVANCIGTSTSLALAAFGVVTTIHMYTNLKSYQCIQLRTLNPYRASLVFSEYLISGQAPLIKEVNDEEPLFPTVRFSNMKSPEKLQDFVLSSEAKAAAADIEERLQLGSKLSDVIHNKEEAIALFDLYRNEGYILTEHKGRFCVMLKESSTPQDMLRSLFQVNYLYWLEKNAGIEPASTYSDCKPGGRLHISLDYVRREFEHAKEDSESVGWVTEGLIARPLPTRIRLGHDRELLLSSPNSS
The following text describes a protein:
Function:
Essential protein that plays a role in the establishment of coordinated motor control. In the developing eye, involved in axonal targeting of the R7 photoreceptor.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MGVCADLGSHRWCRALSTQHNTEKSKEQQQQSQPLEIPEQRASKCRGDIDRTTTTTIPASKTLTASPAKTAAFTVKTTRRRRSRRRAEGSSICVPIRRGQGSTPTPTIQVLQFVLVSLLALLAKNAQAHNIPEDAVHITAILGEGVIFNCHVEFPNDHPVPYVLQWDKKVSETGSDLPIYIWYESYPEHIEEGYKGRVSRVSQDSPFGSASLNLTNIRESDQGWYECKVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPTPEILWYKDANPVDPSPTVGIFNDGTELRISTIRHEDIGEYTCIARNGEGQVSHTARVIIAGGAVIMVPPTNQTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQLQYVTWTKDKRLLEPYQMKDIVVMANGSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLVRKPPAFTVEPETLYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNRIKISGGNITIENLRREDFGYYQCVVSNEVATLMAVTQLVIEGTQPHAPYNITGKATESSITLQWLPGYSGGSEYKQDYTIWFREAGVNDWQTISVTPSGSTQVTINGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPAAPRNVKAATQPPDSFFQLMPDEAGPKPGPPRNVSVTEVSNGFLITWQSPLERAHIVKFYTIKYRTDAQWKTLNRGQIRPEETQYLVKNLVGGRTYYFRVLANSEKSYESSDEVKFPVPARVKHKAITAGVVGGILFFIVAIILSVCAVKICNKRKRRKQEKEFNMVACRITDARNIAANNHHLHNRSTGSISSGQVPLKNNTEHYRDYESVFIVPGHPVIIKIVQTNPNIKSNRHSHCHLHWIWPPDRCTNCHSIYSSPNLEDGDEDDGGGGRRRSVSRIQRSLDGRFVLDVEGVSKLGYSQQTLESGNVDVVDGGLFERRNSNVSQKSSSDDGGFLSRRNFITARASWRRPLVASSSQLSLQSAADSARGFLQGLLKIGAKQSAVPPNSQSYFDEAVSGARYQNVLRPYTSSNNLYGNADRSRPLHINTISGSLSQQQQLYTPSRISRIFSSSPQQLQPHHQQLLLSSGGSGAYPTHFSDLSTVYPPNSAERSSHNLSSRYRYYSQELPSLRTIQEETRRQQQQKQHPLEDHFVPLQLPSPPSWRSYYQSQASYRPRTRWYPRHHSRLFSNRQQQHEMLSPLPQLNLNLRNSMNPGGLEASPESRSSSSGFGSKNTSNHPGSTSEWRLLPPYRAPPSPPKHSGYFGGQQAQGQTPHGSYSYPRATTPPYTMAHWLEMISRLNAATDSNLPKAPCPVDVGSVDGHYEFDPATPTPSASSMLREDLNLHIDTHPYHHHTLGPLSGSLLHSHAPYGGGARKQRSLPAHLPRYDNVEVRLQAMREEFYAYRKRQAMQQMESVC
The following text describes a protein:
Function:
Cleaves the spore coat proteins SpoIVA and SafA. May cooperate with tgl to mediate the temperature-dependent cross-linking of coat proteins like GerQ.
Subcellular Localization:
Forespore outer membrane. Note=Synthesized in the mother cell compartment and assembled on the surface of the forespore.
Sequence:
MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRLIADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQEHYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDILVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFESLIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIETRGVLRIGMPYKSN
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MSIFNQKSKFKIKTEIRTVRETVERPKLKASTSSSSIPTTGSSQHSNVRIAGAGSSLSRASSTPRLNGTSHTTSTSSSARASLTKVTTIPTARRIQSASPIPSINGDGRSSRKRRAIKASSRSPISPHFSEDSDSDSNGDENWEDNLDARKRRKRVHDERPVDVNRKLRHPKIWKGEEADQVERIPGPAIIHAAKVASLEHKCKPALGLKNEEVAVRLQYPGARYPERYELVEGKDKIDAVKDIEKVVQLAASTYLTDEEGKIFLDHQTGILRKLVKSKNRSDGPGFKAALREYNDEFLKLMRKGVIVRNLDKMHGIPRELVDFILDQVYDRTVAPRVELLAKYQNGSDNVYGELNHPFISDILERTNLTSDKVFVDLGSGVGNVTLQAALEIGCESWGCEMMENACNLAEAQYDEFLARCRLWGVKPGKVRLERGDFRKNEKILEVLKRADVVLVNNQAFTSQLNDNLVSMFLDLKIGCKIISLKTFVHDNKNAENDVATSILDVEHLTYPEGYVSWTGASGTYCISTRR
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MKDEVDIDFNGVELINEKDWFKEILNYQQQNNQLHSNQDQDITQYIKNHNQFRMNENYQKKSFTQEELKSNLDYSAINQSVLASSILMLNRADQFNKTNLPNGFLLSPFHQPITTPQSYDYQPPQCKSCFSYINMYCELKDGKDKKNNSNRKWICSICKTSNDILETNNGWWKTQHYKSVFSSETFDIKIRKNKHSQVKKLNNKNPTKSIIDQDNYEEEDDEDDEYFSQRQQNQQSSDQEASAEHSNIYLFLIDENISTTDLKDINKSIRLLIKDLPNNSKIGLLTFSKNISIFEMSAISVNEKSQEGLLSFNSTRLVGGRASLDRSNKYEIQRKRRLYLETILDSGIEERSPKLNLVLNSLLETFENNGTSVVYESKQISLGVAIECALRIVKGQNVNSGRFFVFLNGAPDYGPGAIPRSDDALFINCSSGKRKNVTTEEKAILNNALQYYEALGEKAYRSGFAIDLQLIGYNNFETKILAPLCRPSGIMSCSLDVHSVSNNKYQTRSNILFENMNNAIIKNSGIFGQLDIHVPEFLNLTHLIGPTINPASVSNNKKGASQEQFIEKEQDFIYAEDVDNDRYTSFVISNLQQDICFSIYFNLSEDIPFDHIYVQFVTHLIKSNGIKITRVITKQIKVTGNFEKYLSSVDFKVIATLLSKKIILQSIKDQQPDSSDTGSIANTTQFELDKQLAKITLSCSKVEKSWFFKKTVIIPDLIKSFINLIYKVRKSLIFGQNIQNDDDLTIYQNYLLNSNFTDCQKLLLPNLLLIDDNCQFRNIPLDVCSIDSNAILILDCFINIYILVGSDIEKSDNQDRLNLLDSYIKEIITQRLPSPYIIKFNERDHEVRWLKSLLSSSESYPIDQRLEIVKEIYPQFQNETNQNFLERFNDPFTNDPFTPSNYLREINTKIYDYFI
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MAAPAPALMQLKVRIPENEEVARCLHEKRLSMREQPAGFKEHLDRTFAKAYRNVCAANEPIRTLKEFSKINGVGPWLIRCMKGFFAESKQDSPAKGKKTRVPKCCVTKKKTAASASLGKGPPSNLNCQNAQFSSSQGTLELQPSGKTGSTDFNMLDKDVVSMNNCILAMPPRQSSEEFLEAYEVVLILDDRENFGYCSRKVASKKVADNIGSQFNVPVEVKRLPVGDGIWIARHKKNFTEYVLDFIVERKNVADLGSSIRDNRYKDQKTRLQRCGLRKLMYLVEGDPNTSKGSAASIKTACFTTEIFEGFDVLRTNGLDKSACICPTYDEFERHCHCLQKRTVSQIFALQLMQVPQVTEKVALTVIEFYPTLFSLARAYSMLEGDIHAQEEMLKNKSKMINAGASRNIFRLVWGDGCQSSGLILD
The following text describes a protein:
Function:
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MKEAILFRREWNEEYPFHLNKEEISHLKALRIFSEDKNLRVLNGIGTEWIYEIPGNSVQGIFKKTITHLKSERVSAVATAIPKGNRLEWLLQKGTELGLTHFYFLNFEQSDRKDFNLNRAQKIVEEASIQSKRIFLPEIVSPVSLKEFLISQKKQNLSIYRLDPQGEWKLKPEFFQNAIWIIGPEGGFREKEILLLQERNIPGIKVGDTILKIETAVVFTASLFRYSTIC
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).
Sequence:
MDQHAFPDLPPRLSQRLHSILQQRGWLPPQWDFPDSLALRNLGSLAHDSESAASKVLDNLYSKYEIKKSTSAVIMQEVKMQRQALGLGTGLSPAGGGRVSAQHWQDQANAMQRGGNAAGFTPPRSGHQSTSPLNATAYQANPQQKPPTLSHQRSRETVESDYLLRREPVTPEKSSPAPAMVCSPPSPERPPTSVQAQSPGSVRLSQGGPVVRKLDPLLGPPRAKSPRIGSETTRHASRKGTHQGGSADQQRNADVSNASLGEWDEGVPGSQQSFAFPRLETTPPIRFETPPPEEAGILINANALSQQGLASDTRGLAESFSRFEPPSGFRSYKPPSRGAYLLDPPETKPVGIERTPSSLPLEDKHVLCVTHCETPPLPSSQALRGLPNPSPGLPNPSPSLPNPPLQPITGTWRLETSSSQGPHLVLEAIPGGPVHTRVPLRWEQPLPLPPDLQEGNANLLRSTHSNWRPVQIAEDGSLQGVLWGQTLVNVPRVTAAREAMPPGIQKSLLHGSGMTRDDVSTSSSHGSRVHGLPGSLGGRASLGAPDCDQSTPLRKAFGELEFKKRWLVEYHGGHNLSTLSQTVDDVTLTSSLVAFRSSSLLEIEARLLSFLPRAKHRKLIALVLTREDPDANVVYAVKVRKNRTVELMAPALEKAGTAGGRLFDYDRLLTVYIEDIQKHRATCESVLRDSLTICARTYAFLLPKDATNRDVRILFLALSSDAATDARAGFSPYDSIDDARARVAHFHTCANAARGCSWQIQAHLLTLFSRRSQDSRGAALADELIHTDGNVFISEDLAKLVPAGISQGCLPKEKSGHDIPLVIQFRLFHEGEAFKGTVTLNRLLPPNTLVLPGSCRKVARDHAWAEALPRALSSFEVCQSSQEPSGEARLNQQLILLLWHGGVPTETFMRLLDDALEALLTSCTDVAAAYKVANSFGSDDRPKQQALDALIMLTSGFDMHELRLRSIVRTLQKERFVELSRGRIPVKRTYSNLMGIADPTGQLAPDEVMVILLSAFDDLVGLVRSRERLEDELRLPGNFPISAGRSAVLTSEKVLLFRQPGLHPGDIRVFKIQKVPANGPRSAADMMAGGDLDGDPYWVCFNEELCAPFQPSDPMERLQPSGVRPEPLPNSADELNAKLREHFLTCAFAIQGAIGGAQRNWLAHADWGSQDERPIRGGGPGSATCLALNEIYCRALDAGKSGEKVSVPPELLASHYPSYMEKGKETRERGGNLTAFTEYESKSVLGRIYQRVYPLLHEAQEKPEEVIFDEDLKLDLAGNNAPVWTQWTKWLHEYNQSVREAMSGHRADAREAAMEQVKLKYKRLLWQQHLPRDVTPADADIIARLESAAPPDDVILAARAAYSVTYSEANAAYERGRDGRQPDEGRGG
The following text describes a protein:
Function:
Toll-related receptor which binds to the neurotrophin spz5. Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe. Involved in the targeting of specific classes of PN dendrites (Va1d, Va1v, DC3 and DA1). Functions with Toll-7 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS). Possibly functions with 18w and Toll-8 during convergent extension, to help direct proper planar cell polarity, cell intercalation and axis elongation. Promotes heterophilic cell adhesion with 18w in vitro. May be an upstream component of the NF-kappa-B (rel) regulatory cascade.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MIYYMLLILPVVLAQDQQHTTESLSTKHHQQQQLSHSNAIMGEAGVSNSQLMQPSTPARTLRPLTAGAGGDPSLYDAPDDCHFMPAAGLDQPEIALTCNLRTVNSEFDTTNFSVIPAEHTIALHILCNDEIMAKSRLEAQSFAHLVRLQQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLENDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGDLPQRDIDMDMRHYLRTSTCIEWDDKKFWQKLRLALPLPNGRGNNNKRVVSGCLSGRTPSVNMYATSHEYQAGNGGVIPPPSARYADCGSNNYATINECAAAGGGRGYKPIPTSASAAAAACKFNTMNQLSKKQQRDLSVAGMAKTLEHQHHHNHQANRRSQHEYAVPSYLPSAAPAYDSVDYAKQQIRNNANCECVNLGTAKRAAGKNPASGLPSSFSSNFVPPGGASYNCKKSCSCIGDDELLCSCGGGGGIGVNLLESGTQSSVTMSSSSNNSRQPELTHYESNLSLNDDEDEDHDQQKNLWA
The following text describes a protein:
Function:
IF-3 binds to the 28S ribosomal subunit and shifts the equilibrium between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.
Subcellular Localization:
Mitochondrion.
Sequence:
MGPLSTLSACTSKIYQIHEWKDRKAIKKSMCHLMAALFLKRLTLQTVKSENSCIRCFGKHILQKTAPAQSSPIASAPRLSFLIHAKAFSTAEDTQNEGKKTKKNKTAFSNVGRKISQRIIHLFDEKGNDLGNMHRANVIRLMDERDLRLVQRNTSTEPAEYQLMTGLQILQERQRLREMEKANPKTGPTLRKELILSSNIGQHDLDTKTKQIQQWIKKKHLVQITIKKGKNVDVSENEMEEIFHQILQTMPGIATFSSRPQAVQGGKALMCVLRALSKNEEKAYKETQETQERDTLNKDHGNDKESNVLHQ
The following text describes a protein:
Function:
Involved in ciliogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MAASQRAATPAAARLQSPGDSSPGAQAAQSQREDPSEAATAADAALRDEEDGEEAAPRAQARADFNTNISEVDEQTQISNEDFVDFSDICHSNEEYFRKLEELKAAHLETMAKLEKMYQNKLNLKVQPVIIREEASSVSSRSESEKNSYHPISLMTSSEPDLGPSSSLIMSSSEDELPNLEKEYPEKKRVVMSYAKELINNMWTNFSVEDYIRCEDAYFPAVEKTKKKPREWVPKITVPEPFQMMIREQRKKEENMKSKSDIEMVHQLLKKQEEESECKKKFRATPVPAFVFFPLYHDLVKQNEDRRKRLKEKNKEALLASQKPFKFIAREEQKQAIREKKLRDLFKSKKKTNRFKARPVPRSTYGSATKEKLKEEELYRDIMTQLKAQELLQNPSPLPSRSGHKSCAPRKLKRPEQPERLKCTHKFRCQIADFEKLPEGYQKHLSEQKCSKLPTSHKPPNLHAASTASTKREKILADIAADEEHSKETRSFLSPRNKSPGRSASAKPVPCNCPPPMPTVSSRGREQATRKSEKERMREYQQELEEREEKLKNRPLLFERVAQKNARMAAEKRYSNTLKALGLSDEFVSKKGQSGKVFEYFSNQEMKNFTEDKESFDEEENVEERASGEENHFIDTNSQDSYKEKEETDEESGEEKSVKE
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGRGKIEIKRIENTTSRQVTFCKRRNGLLKKAYELSILCDAEIALVIFSSRGRLYEYSSNSVRSTIERYKKASASTSGTAPVIDVNSLQFFQQETAKLRQQIQTLQNSNRHLMGESIGNMTAKELKGLENRLERGIGRIRSKKNELLLAEIEYMQKREADLHNENMFLRAKVAEVERALQQEAAAEDQTMAMGPAAVGGATTELKALPASFDPRGYGYYQQQQQQHVLAAASAASSSQYSEQPQGQGQQEYEYHHQTALHLGYHVKIHSAAGGKGFL
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
Subcellular Localization:
Nucleus.
Sequence:
MQSSGKRISAYAVFKAKQNATPKKEVRGKVQKPEASTPIAGLIRQGQGKLKKLRESARSKKTKKAVKRSEGTVGRLQADNMDVNDDDRPSSRLSSRTRPTRTEAADSKPRGSSQKKRKSPYTTTPDKGGRKKVTPTLQPTEPIAKRLKYQESGNESTIAGPSSSVSDNSLKRDSHQHGKDVFSWLISPFKVEDYFKNIFERKPLFLKRHKPGYFTDIFSSKELSNILKENDVQFTRNIDVTTYTDGKRETHNPTGRAQPQVVWDYYNNGCSVRVLNPQSYSTRVWQLLAALQEFFGCFVGANIYLTPPGTQGFAPHYDDIEAFVLQLEGKKHWKLYNQRSPAEVLPRFSSSNFTDADIGQPILDTTLEPGDLLYFPRGVVHQASTPSETHSLHITISACQKNTWGDLMEHVLTRALHVVREENIDFRKSLPTDYLNYMGVAHEDLDDERRQPFMKKIGDLFSKLLKSAPIDAAADQMSLEFFHTSLPPVLEEAEESCSVFGESASCRNGKVSGIVQLGEDDQIRLLRRNILRLVPEEDKVLVYHSLENSRVFKEKELQYFEIPPELAPAVEHLLHSYPDYVPVSNLADQLQPVNDEIADPEDLAQTLYEKGLLMTKFKLEPSVSSSSDGHREVTIHQSR