lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding. Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding. Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN.
Sequence:
MDMGNQHPSISRLQEIQKEVKSIEQQVIGFSGLSDDKNYKKLERILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQNANHPHRIEIQNIFKEAQSLVEEKIVPFYNGGNRVTDEFEEGIQDIILRLTHVKTGGKISLRKARYHTLTKVCAVQEIIEDCMKKQPSLPLSEDAHPSVAKINSVMCEVNKARGTLIALLMGVNNNETCRHLSCVLSGLIADLDALDVCGRTEIRNYRREVVEDINQLLKYLDLEEEAGTTHAFDLRQNHSILKIEKVLKRMREIKNELLQAQNPSELYLSSKTELQGLIGELDEVTLEKNPCIREARRRAVIEVQTLITYIDLKEALEKRKLLVCEEHPSHKAVWHILGNLSEIQGEVLSFDGNRTDKNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVKLAQNILSYLDLKSDEWEY
The following text describes a protein:
Function:
Involved in branched-chain amino acid transport.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNKNKESLHLSSPAINTHMNKRSQIWAAFRSAFPYTIPIFAGFLFLGIAYGIFMHSLGFSAIYPIIMSFMIFAGSMEFVAANFLLGAFNPMNALFLTLMVNARHLFYGISMLDKYRGTGKKKLYLIFGMCDESFSINYTANVPANVDKGWFMFFVTLLNHLYWVAGAAIGGIFGSYVKFNTEGLDFVMTALFIVIFIEQWMKEKKHYSALTGLGLSVASLILFGGNQFIIPAMLAILGVLTVLRKPLEKAEVSV
The following text describes a protein:
Function:
Involved in the synthesis of phytochelatins (PC) and homophytochelatins (hPC), the heavy-metal-binding peptides of plants.
Sequence:
MAAMAGLYRRLLPSPPSVDFASSHGKQLFFEGIQNGTMEGFYRLVSYFQTQSEPAFCGLASLSMVLNALAIDPGRKWKGPWRWFDESMLDCCEPLEMVKSRGISFGKLVCLAHCAGAKVDAFHASQSSIHDFRKYVLKCSTSDDCHVISSYHRAALKQTGNGHFSPIGGYHAGKDMALILDVARFKYPPHWVPLTLLWEGMNYIDESTGQSRGFMLISRPHREPGMLYTLSCKHESWNSIAKFLMDDVPFLLKSEDVKDIHKVLSVIFTSLPSNFEEFIKWVAEIRRREDGDSSLSAEEKTRLAVKEEVLGQVQETRLFKHVSSFLSSSCGRQKLTSGDGDTLPAIAASVCCQGAEILDGKLSSSAAYCCPETCTKCWNAEDDKSITMVSGTVVNGNTEQGVDVLIPSSSGKLCCTCSSKKNIRMHPASTDVLTVLILSLPSTTWAGITDNQLLAEIHDLVSTENLSTLLQEEVLHLRRQLHILKRCQEGKVDEDLGAPSS
The following text describes a protein:
Function:
Cyclin-dependent kinase that acts as a master regulator of the mitotic and meiotic cell cycles.
Sequence:
MENYQKLEKIGEGTYGVVYKARDLANSGRIVALKKIRLEAEDEGVPSTAIREISLLKEMRDPNIVRLLNIVHADGGQGHKLYLVFEFLDLDLKKYMEALPVSDGGRGKALPEGTGAGLHNLGLGEDIIKKFMSQLCEGVRYCHSHRVLHRDLKPQNLLIDRDGNLKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGGRQYSTGVDMWSVGCIFAEMCTRKPLFPGDSEIDEIFKIFRLLGTPTEDIWPGVTSYPDFKASFPKWVRDYNVPLCQNLDDVGLELLESMLVYDPAGRISAKAACNHPYFEDYNPKPKSKYRDSSRYA
The following text describes a protein:
Function:
Hydrolyzes 1-carboxybiuret to urea-1,3-dicarboxylate and NH(3).
Sequence:
MKTVEIIEGIASGRTSARDVCEEALATIGATDGLINAFTCRTVERARAEADAIDVRRARGEVLPPLAGLPYAVKNLFDIEGVTTLAGSKINRTLPPARADAVLVQRLKAAGAVLLGGLNMDEFAYGFTTENTHYGPTRNPHDTGRIAGGSSGGSGAAIAAGQVPLSLGSDTNGSIRVPASLCGVWGLKPTFGRLSRRGTYPFVHSIDHLGPLADSVEGLALAYDAMQGPDPLDPGCSASRIQPSVPVLSQGIAGLRIGVLGGWFRDNAGPAARAAVDVAALTLGASEVVMWPDAEIGRAAAFVITASEGGCLHLDDLRIRPQDFEPLSVDRFISGVLQPVAWYLRAQRFRRVYRDKVNALFRDWDILIAPATPISAPAIGTEWIEVNGTRHPCRPAMGLLTQPVSFAGCPVVAAPTWPGENDGMPIGVQLIAAPWNESLCLRAGKVLQDTGIARLKC
The following text describes a protein:
Function:
Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase. May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1.
Subcellular Localization:
Nucleus.
Sequence:
MKLQCEVEVVNRHLPTFGLKGRGKGTRAVLSLGRPSDKTLPQSQSGTAHLVIHTLKDKTGSRYKLKENIEQFFTKFVEEGKATVRLKEPAVDVCLSKANSSNLKNFLSAVRLAHQGCAVETLPLLTLAPLKTSEVEKPKTKMVITSKKDYPLTKNFPYSLEHLQASYCRLARIDMRMLCLKKLKKLDLSHNHIKKLPATIGDLVNLQELILNDNHLETFSEVLCSSTLQKSLQSLDLSQNKIKALPLQFCQLQELIYLKLDDNELIRFPFKIGQLSNLRFLSAARNKLPFLPSSFKKLSLEYLDLFGNVFEQPNLLVPNIQLTIPLTLLETSARAVLNYRIPYASHIIPFHLCQDLDTSKSCECGKSCLSSFIQATITMNLHYVAHTVVLVDNMGGTEAPILCYFCSLTCYSQFLDKINKK
The following text describes a protein:
Function:
Promotes the exchange of Ras-bound GDP by GTP (By similarity). Induces the formation of substrate-attached pseudopodia, that leads to increased adhesion and thereby negatively influencing cell speed and polarity.
Sequence:
MTDYPFYKPDDETNIIYNININKKEGFSAIKSCSLAKLIEKLTSTKQLHTYFSSAFFLTYRDFTTPLEIINLLISRYTGPPPDSSKDSLRLFEIEVDIVQANVLSIFRTLIGTLIQVDFDTPKLSSSIIEFFNSLPESVKNELFLEFFKAKKMARPPGSIPKPVNSNIISSAASTMRFSYSVSPKTQSPNSTNNVLSGLLSNNGSNTMNGINGTSNNNVNSNNNNNNGTTNISSPNFDPSRSSMKMGKGIMKLLQSNIANFNNQQNGGGGGGSNNGTSPQSSPSSTLSSTNSLFNQQPSLSMLNDDGSVQNNNNNNNNNNNNNNVNEISTINVQLPPSTPPINGIPGEKTAFLPEAIAKELTIMEWELITALSVSDITSKEWNKSVNIQNLTTWFNRISSWVSTKIISKETPEERAIIIEAFINIANFAKELKNYNCVMEILGSLHGSSISRLKSSWALLSQKTNDMFQILNNLMTTDGNFKNYRKILTTVLPNEPCIPYLGLFLTDYTYLDESNPSLSTDSNLINIDRIFLISTRVQEFFQLFTNCNYTFISNMSVRDAILGEKVWDENEIFRLSKIREETSSLQSLKESNGIGNSNSTSGGSSSSLVNKDGSGGGGGSGGGGSVNSKGDGKGDGKDNRDGRGDGNSNCGNGSGISSKDKDLLLSSSSSAASHTVRRKNFVTKYRMSFTGNDPLPSVSSTLSEREWKILTTNSKTIIYPRGKTVLSVGETNTNIYRVISGRVKVETLKSFNSSDADLGAGGGGGGDNRGEDNSLMAIKARNRLSLNLPAQDDGYYVEEGEIFGQESFLYTDRPMLSNIIVDSGECELMEIEKSFVLQLFASEHQLSATFYKFIGVIQAQLLKSIYINFTSNYGNGGSGGSGSNGNGGGSSNGAGGGGLSSSVSIGNLNSPNINRIDFKRRSTIFETPSSLDILRDGNDSSFRTKFGLSQDEVIIKRYQCKHNNMNGTLYITKHNLCFEGKFLGINKNKTIPFDRTDKILTVDKNIMTVTTKEKVKKFTFKSHDDLNEGYGISVQIWANHLNINVKQQLQLQQQQLQQQQQQPSQQPSQQQSQSSQLQQSVSASSTTPPVPNSPKVGRGESFSNIKDLPSKDEWNQILKGTKPLTFKKGEILICEGVEYQKMFQIVKGECSVVKSLLPTPLDQNIFNNINNNNNNNNNNNNNNNNNNNNNNNNNNNGNNNNSIFKNNSSISNTNSNTSIDGGVGGGLSPQTLVDPKNSVIVSKLTHGSIFGEMSFLLPGGSATSLVVSSDEVEVYIIESYFLHILLKSKPYLASKFYKYLACVLETRVRNLT
The following text describes a protein:
Function:
Transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway. Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes.
Subcellular Localization:
Nucleus.
Domain:
The DELLA motif is required for its GA-induced degradation.
Sequence:
MSSSFRSDMGTDPYDSVGDDRWIIASASDRGSSRGEIDSLLHGAGYRVRSTDLRHVAIGLEQLESTMVGDQCVASSAEAIHYNPSDLTAWVDSMLSELAPDPHLLRHPLSTAAANTWADPTQQRPSLHRLENHHQHRNVPAVSLQSMDEEEDAAIRLVHLLVSCADSVQRGDSEMAGSLLDQTRLALARVNTGFGIGKVAGYFVDALCRRLYPPPPSATGGGGSAANLEILYHHFYEACPYIKFAHFTANQAILEAFQGHDRVHVVDFNLMHGLQWPALIQALALRPGGPPLLRLTGIGAPSPDGRDALREVGLRLAELARSVQVRFAFRGVAATRLEHVRPWMFQVAPGEAVAVNTVLQLHRLLGDRASPEGGDAAAAEPIDTVLEWIVGLKPKIVTVVEQEADHNKPSFLDRFTEALFYYSTMFDSLEGGRVGGSHRGGQQQQQTVVAAVAEAYLQREMCNIVCCEGAARVERHEPLARWRDRLGRAGLRAVHLGSNAFKQASMLLTLFSGEGYCVEEVAGCLTLGWHSRPLISASAWRADDADDASPPRDHQTLVLQDHSSSITSGSNNVVDGDDHLHQHSVMRSHMGSSDRINDTGSGSSCSRV
The following text describes a protein:
Function:
Transcription factor that regulates pseudohyphal differentiation, invasive growth, floculation, adhesion and starch metabolism in response to nutrient availability.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSKPPPQHQSKNANNSLSSPVSDKQSNDSRQLLLAHLYNYFKTNGLEETAQALLIECNNTIPKATTNSKGYSLDNSGPDQKDTFLDQWWGLLWSIQSSINPNLNQMTNPSGILTPQHQMIVQQRMLQQQQQQAQQQQQQAQQQQAQQQQQQQQLLQQQRLQQQAMIQQQHQQQLINNLSARQQQVGLSTTTNQMGPPGSNSNNLQSNMSPNNEQLQSQARLQQLKLQFQQQQQQQLQQQQQQLQLQQQQQQQQQQQQQQQQQQQQQQRQQQRQRQKKFQRQLSTSSQKSPVINNGQPQQQLQQDQRPASAPQNQPTPGNNNNNNNNTNAVSPKLHRQSVDDYQMNLLQMENQNNSQRQKYLNNQQTRNSQQQQQQQQSQSQSQQSSPFQPPAQQPKNSTTTSTNTTTSRAQKSSRKQQPKNSRRQSVQQQQQQQPQQQPQQSQQMSTSSQSFTAANNSNNVNNTFDISPQIQDQGMLSTKEQQQQPQQPQPQPQSQPQSQSQSLPSNNNNNNNNKQDVVNVVFDDAFFSGNLLLDDFNEFANSTSNNGNGNGNNDMNSQFNNTQTERIMFSMPPNQNQNQFPSQSGDGGGGGGGSMQPNFFEGIELGDGNNSGNGDDDDAPIITTDWLSSMGSGPGYE
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MKRNCNLELPLVTMPSVFSDSSAHEHSYQFYNMLNMEDDQSPNQKQKQHQLTVFYNGRIAASDVTEFQQARAIILLASGEMEDEKRSAIPTSGLSMKRSLQRFLEKRKTRLQCTSPYPITTLHK
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSWDSYVDNLIAQSKDASGTTHCDKACIIGKDGSAWTTMPTSDTSNNLKLTPEEMANIAKCFKSKDFAAFMSSGIYVNGTKYQFLREEDSKLVLGKKKGEGSLTLQSSKTAIVIGHCPEGGQQGNLNKAVGVIAEYLESLSM
The following text describes a protein:
Function:
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
Subcellular Localization:
Cytoplasm.
Sequence:
MLRVAINGFGRIGRNVLRAVYESGKRDRIQVVAVNELAKPDAMAHLLQYDTSHGRFGKKISHDQQHIYVHHQNGEYDSIRILHLSEIPLLPWRDLGVDLVLDCTGVYGCQEDGQQHIDAGAKLVLFSHPGASDLDNTIIYGVNHETLTAEHKIVSNGSCTTNCIVPIIKVLDDAFGIDSGTITTIHSSMNDQQVIDAYHNDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVRVPTVNVTAMDLSVTIKSNVKVNDVNQTIVNASQCTLRGIVDYTEAPLVSIDFNHDPHSAIVDGTQTRVSNGQLVKMLVWCDNEWGFANRMLDTALAMQATQ
The following text describes a protein:
Function:
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Sequence:
MGTPESQLRLRKTDQNPSADQNSLSSSSNPGRAPIGSDYNRPIFKLGIVSLSMAILPIGTYFGTLGHVFDKTNTTAAAISAIVVTNIILVGYIFAALSESDDEQNNNTTSTDLQKRKKKDS
The following text describes a protein:
Function:
Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel, that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.
Subcellular Localization:
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.
Sequence:
MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGDQHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVSEVESNYGATEEDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPGLMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK
The following text describes a protein:
Function:
Expression is vital for development; may be involved in transcriptional regulation. In embryos, muscle specific expression is required for segmental nerve b (SNb) motoneuron target recognition within ventral longitudinal muscles. Has a role in establishing and maintaining embryonic muscle attachments, adult sensory cell formation (macrochaetae) and morphogenesis of adult appendages (legs, antenna aristae and male external genitalia). Has a role in the morphogenesis of the class I dendritic neurons: selective expression of ab in class I da neurons plays a pivotal role in forming dendritic arbors, which are characteristic of the class I cells. The development of more complex arbors of class II-IV neurons depends on the absence of ab.
Subcellular Localization:
Nucleus.
Sequence:
MTESTQLQTAENNNAGVVKMEPPPPATSSVSVSAAAAAHALSSLSSLTMAATGSALSPATPPPSLNLSHQQQQHQQHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHPIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADVNGGYPYSKALSAALSHNSSNNNNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSNSNSNNHSSSHNNSSSNNISGSLNSSLNSPFSAPQIPPPVTASSAAAAAAAAASLTAAVAAAAAATAASAGSSSSAASGQTSGTPAIQELKASSAASPVRNPNPNPSKASSSNHWDMGEMEGSRKSHLTPPPQKRIKSADLFRAQHGISPERLLLDREFPVAGQHPLTRNRSGRDTSKDRERNLELRESLLGQALENSNGQQANPKHELGQSAGEDSNSSDTEPSDRGDGQHDGTLDGIDNQRSHSFPNAFLGLQGIPGLLPGPSGINSDFVSRRSLEMRVRATDPRPCPKCGKIYRSAHTLRTHLEDKHTVCPGYRCVLCGTVAKSRNSLHSHMSRQHRGISTKDLPVLPMPSAFDPELASRLLAKAGVKISPAELRARASPTGGSGSSGGGGGGGSSQAKLDLSNASGGPMDDAEDSDDDPEDLTTGNGLYGMGGSSSDLSRYHESLLSNFGHARMRNEAAAVAATAAALGQPKDLGVQLPNSNAPGQSLLDTYLQFITENTFGMGMSQEQAAAAALRAKMAQLNAMGHSLDNLPPGLLPGQFDLSKLAAGNPAFGQSGPGLTIEPIMRHEQAAGNLSPNRPLALNSGGRMMGHDEMAENDGDMRREGSEPMDLGLDNNQSGSNHEVANSDAEENYSEDEGVHNT
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MSAAATTTTTTTCRSILDKPLNQLTEEDISQLTREDCRKFLKDKGMRRPSWNKSQAIQQVISLKALLEPSVDDSASGVLRKAVVSLPRATSNSVDSVKEPSPDVQVSLSAEESQGRKDPPKSAPSGDRSADIDNNAVSPRSPCATNPSVGQMTIFYCGKVNVYDGVPTDKAQAIMHLAASPIHLPQDDALCGAAALWSPCHLQISSDKDHLIPPCNNISHIMQTEKMTEYAQQYRDKGSIPRDPEGQANRKVSLQRYLEKRKDRGRLKIKKNMGSTNSSLEMYLNHQVRTHAPNGKSSRSSTSSPPQHGLPQTLVSSVDNQLKSAGLAVDLNDKDVQDC
The following text describes a protein:
Function:
Involved in secretion of bacillibactin.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIITVYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGRVLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWYWFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFIIGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKGRMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESEQCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKKSEEEKNLGTV
The following text describes a protein:
Function:
Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. This subunit forms the outer membrane channel.
Subcellular Localization:
Cell outer membrane. Note=Most of the protein is in the periplasm which it traverses to contact proteins of the cell inner membrane.
Domain:
The N0, N1, N2 and N3 domains are periplasmic, while the secretin and S domains form a channel that is partially inserted in the outer membrane. The N1, N2 and N3 domains each form a periplasmic ring. The secretin domain forms a double beta-barrel structure; the outer barrel has a diameter of about 110 Angstroms while the inner barrel forms the central gate with a small pore in the closed state.
Sequence:
MSERMTPRLFPVSLLIGLLAGCATTPPPDVRRDARLDPQVGAAGATQTTAEQRADGNASAKPTPVIRRGSGTMINQSAAAAPSPTLGMASSGSATFNFEGESVQAVVKAILGDMLGQNYVIAPGVQGTVTLATPNPVSPAQALNLLEMVLGWNNARMVFSGGRYNIVPADQALAGTVAPSTASPSAARGFEVRVVPLKYISASEMKKVLEPYARPNAIVGTDASRNVITLGGTRAELENYLRTVQIFDVDWLSGMSVGVFPIQSGKAEKISADLEKVFGEQSKTPSAGMFRFMPLENANAVLVITPQPRYLDQIQQWLDRIDSAGGGVRLFSYELKYIKAKDLADRLSEVFGGRGNGGNSGPSLVPGGVVNMLGNNSGGADRDESLGSSSGATGGDIGGTSNGSSQSGTSGSFGGSSGSGMLQLPPSTNQNGSVTLEVEGDKVGVSAVAETNTLLVRTSAQAWKSIRDVIEKLDVMPMQVHIEAQIAEVTLTGRLQYGVNWYFENAVTTPSNADGSGGPNLPSAAGRGIWGDVSGSVTSNGVAWTFLGKNAAAIISALDQVTNLRLLQTPSVFVRNNAEATLNVGSRIPINSTSINTGLGSDSSFSSVQYIDTGVILKVRPRVTKDGMVFLDIVQEVSTPGARPAACTAAATTTVNSAACNVDINTRRVKTEAAVQNGDTIMLAGLIDDSTTDGSNGIPFLSKLPVVGALFGRKTQNSDRREVIVLITPSIVRNPQDARDLTDEYGSKFKSMRPMDVHK
The following text describes a protein:
Function:
Plays a role in the inhibition of host immune response. Participates in the inhibition of host autophagy by interacting with and inhibiting host PKR/EIF2AK2. This interaction also prevents the interferon-induced shut down of protein synthesis following viral infection. Downmodulates the host RLR signaling pathway via direct interaction with host RIGI and IFIH1. Associates with endogenous HSP90 to disrupt the HSP90-TBK1 complex and induces destabilization of host TBK1 through a proteasome-dependent pathway. May also participate in nuclear egress of viral particles through interactions with host NCL and regulation of the viral UL34 mRNA.
Subcellular Localization:
Host nucleus, host nucleolus. Host cytoplasm. Note=Following infection, it is released into the cell cytoplasm.
Domain:
The N-terminal tetrapeptide may be responsible for virion incorporation; The C-terminal half, rich in Arg and Pro residues, seems to be responsible for the RNA-binding activity, and for the association with ribosomes and the localization to the nucleolus. This region may adopt a poly-L-proline II helix secondary structure.
Sequence:
MSQTQPPAPVGPGDPDVYLKGVPSAGMHPRGVHAPRGHPRMISGPPQRGDNDQAAGQCGDSGLLRVGADTTISKPSEAVRPPTIPRTPRVPREPRVPRPPREPREPRVPRAPRDPRVPRDPRDPRQPRSPREPRSPREPRSPREPRTPRTPREPRTARGSV
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Acts as an RNase. Upon expression in M.smegmatis inhibits translation, growth and colony formation. All its toxic effects are neutralized by coexpression with cognate antitoxin VapB2.
Sequence:
MTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRALEVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA
The following text describes a protein:
Function:
Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Nucleus, nucleolus. Cytoplasm, perinuclear region. Nucleus, gem. Nucleus, Cajal body. Cell projection, axon. Cell projection, growth cone. Note=Localized predominantly in the cytoplasm in serum-starved cells growth arrested in G0 of the mitotic cell cycle. Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized throughout the cell during mitosis. Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle-dependent manner. Colocalized with EGFR in the cytoplasm of quiescent cells. Translocates from the cytoplasm to the nucleus in a epidermal growth factor (EGF)-dependent manner. Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens. Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons (By similarity).
Sequence:
MAASGAVEPGPPGAAVAPSPALAPPPAPDHLFRPISAEDEEQQPTEIESLCMNCYCNGMTRLLLTKIPFFREIIVSSFSCEHCGWNNTEIQSAGRVQDQGVRYTLTVRAPEDMNREVVKTDSATTRIPELDFEIPAFSQKGALTTVEGLITRAISGLEQDQPARRANKDATAERIDEFIVKLKELKQVASPFTLIIDDPSGNSFVENPHAPQKDDSLVITHYNRTQHQKEMLGLQEEAPAEKPEEEDLRNEVLQFNTNCPECNAPAQTNMKLVQIPHFKEVIIMATNCENCGHRTNEVKSGGAVEPLGTRITLHITDPSDMTRDLLKSETCSVEIPELEFELGMAVLGGKFTTLEGLLKDIRELVTKNPFTLGDSSNPCQKERLQEFSQKMDQIIEGNMKAHFIMDDPAGNSYLQNVYAPEDDPEMKVERYKRTFDQNEELGLNDMKTEGYEAGLASQR
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
Sequence:
MTIGKHFLKHHLHQVRKLFCKKMQPSVRLKEPRRKRARAQAAHQEPLPVSLQCSQASTFNNWKVCKGFYDGGSVLVHDLDEIEFIYINGFFGKGAHSRGPPELLAEYLEADERFLIPCKKKRNDIEDDGLPPLPFPTLPSSDVHEPLVLSLCEAFFLTYGLGCLVIYDDQKQKPMSILRTWRLFMNFDPNFVVTYAAYHYLRSKGWVVRSGVKYGSNFVLYKDGPAFYHSTYSVVVKPVLHNSNDNIIHVGNSSNNNNSNNNNNNDNNNNHMKSNNNVDGDGDDPCAISDWTSLSRLNRITEQVAKDLVICYVIQPDNNNNNNDNNNNNDNNNSNDTNNNSTDDKNDNNNSNVNFWNSPNCLKFFKIETVTIKRWISNKERNTADTN
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MPSFDVSVVTQVKKILEQEAGYLRLRTSEGDIGILPNHAPFVAELSMGKMEIESPNKDRRDIYFLSGGFLEISDNQATVIADEVFPIEKIDVESEQALVENLKKELEKVSTEEEKRKLQKKIKISLAKIDAKNN
The following text describes a protein:
Function:
Plays an essential role during the late stages of embryonic neurogenesis. May either fine-tune the guidance or the spatial maintenance of the migrating SNB and in nerve roots, which are composed of axons originating from distinct groups of motor neurons and may be required to either guide or maintain the position of these nerves along a direct and straight path to their ultimate targets in particular muscle fields. May play a role in egg chamber development and/or may confer essential maternal contributions to the early embryo.
Subcellular Localization:
Nucleus.
Sequence:
MAEYWQQLTNGAGEAGPGNESSAMADCNGGHESAAVGGSCNRHSNNNYVNFNQFIMQHNLGGGAPSNATSTMQHPVGSSYTNFSLGGGGGAFGLNPPVASASTSHFANVSHQSPNFYSQAMIPTYQNGDGIARVTVTSSYGSVNPSNSNFSSFYTPFGNNPFDFSASKLQASAPEFVPNFAKLSLEETPAAATTNGNSTASLETAINETRPRTLRAQEPAERGANNQCSNHNYERERERERDRDRDRERDRDRDRDRDRDRDRDRDRDSRPGNTRQQRRSDYRDDREDRYERSDRRRPQKQQRYDNHRSNKRRDDWNRNRDRINGFPRAVDDLDTSNESAHPSPEKQSQLQQISPRRGPPLPPADNEKLSQREKLVRDIEQRRLECLVCVEAIKSHQPTWSCRNCYHMLHLKCTITWASSSKSEVGWRCPACQNVLQDLPRDYLCFCGKLKNPPVSRTELAHSCGEVCCRIEGCSHACTLLCHPGPCPPCQANVVRSCGCGRSTKTMQCAMKEEVLCGEICDKLLNCGEHRCQAECHSGKCAACSEQVVQQCHCGKQERKVPCTRESQDKRTYSCKDSCGQPLPCGHHKCKDSCHAGSCRPCKLSPEQITSCPCGKMPVPAGQRSSCLDPIPTCEGICSRTLRCGKPAHPHQCGSKCHLGQCPPCPKQTGVKCRCGHMDQMIKCRQLCNRADDARCKRRCTKKRSCGKHKCNVECCIDIDHDCPLPCNRTLSCGKHKCDQPCHRGNCPPCYRSSFEELYCECGAEVIYPPVPCGTKKPICKLPCSRIHPCDHPPQHNCHSGPTCPPCMIFTTKLCHGNHELRKTIPCSQPNFSCGMACGKPLPCGGHKCIKPCHEGPCQSAGEICRQSCTKPRPTCGHKCAAACHEGACPETPCKELVEVQCECGNRKQNRSCQELAREHSRIATIQLASSMAEMSRGNYMELSEILAPAKKSNKTLDCNDECRLLERNRRLAAALSSGNSDTKQKCLTKYSEFVRGFAKKNPALTKSVYETLTDLVKLAKESKQRSRSHSFPTMNREKRQLVHELCEVFGIESVSYDKEPNRNVVATAHKDRCWFPATSIMEVLARESGQRRVPVPSNNAWGLKK
The following text describes a protein:
Function:
Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Recycling endosome.
Sequence:
MCQLWCSSIPPSQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWVKRQLVDYEEKYGRMFPREWCMTERISVEFCHVTRTELSKIMRARAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLKKLESPPPSTNPFLEDETAAETEELALEKGELEQPKKPKAPDNPFHGIVSKCFEPHLYVYIESQDKNLSELIDRFVADFKAQGPPKPNTDEGGAVLPSCADLFVYYKKCMVQCSQLSTGEPMIALTTIFQKYLREYAWKILSGNLPKTSSSSGGLTISSLLKEKEGSEVARFTLEELCLICSILSTAEYCLATTQQLEEKLKEKVDVSLTERINLTGEMDTFSTVISSSIQLLVQDLDAACDPALIAMSKMPWQNVEHVGDQSPYVTSVILHIKQNVPIIRDNLASTRKYFTQFCIKFANSFIPKFITHLFKCKPISMVGAEQLLLDTHSLKMVLLDLPSIGSQVVRKAPASYTKIVVKGMTRAEMILKVVMAPHEPLVVFVDNYIKLLTDCNTETFQKILDMKGLKRSEQSSMLELLRQRLPAPPSGTESSSTLSLMAPTPEQESSRIRKLEKLIKKRL