The following text describes a protein:
Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components (By similarity). Required to assemble a stable basement membrane and for organizing receptor complexes and cytoskeletal components to the proper cell surfaces. During embryogenesis, does not require the presence of collagen type IV in order to associate with cell surfaces, prior to assembly of the prototypical basement membrane. Plays an important role in muscle contraction of the body. Probably plays a distinct role from the related laminin subunit alpha epi-1.
Miscellaneous:
MISCELLANEOUS: Tissue-specific expression of the laminin alpha subunits lam-3 and epi-1 begins early, before or as organogenesis proceeds; furthermore, the tissue localization of the two alpha subunits are independent.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Secreted, extracellular space. Secreted. Secreted, extracellular space, extracellular matrix, basement membrane. Note=May be localized to neuronal cell surfaces by specific receptors.
Sequence:
MRLWLGLLAVSNIALGGWNTSEDASIWENYVEDSNYHEFISSESERGLFPNIFNLATNSLITATDTCGQYTAEEYCKLVEHVLLRKTTNTQSPQCDICDANNVHKRHPIEYAIDGTRRWWQSPSLANGLRFEKVNITIDLRQEYQVAYIILKMGNSPRPGTWVLEKSLDGEYYEPWQYYAMQDAECMRQFGIPATTGVPRFQKEDEVHCTSEYSKITPLENGEIHTSLVNGRPGAENTSLELQKFTRARFVRLRLISPRTLNADLMIINKKSDSLDKSVTMRYFYSISDISIGGQCICYGHAESCPSDPVTGQFKCECRHNTCGESCNRCCPLFNQLPWKPGTNSHPNVCQQCQCFNHAHSCVYDDELDRNKWSITPEGVYEGGGRCLECAHNTEGFNCERCKDGYYRPSGLSHYREDACRTCECDPVGSVSDACVRDDQSAENGQKPGDCICKPGFGGRRCERCAPGYRNHPTCEPCPCNRAGSVNFDTCDGASCQCKANVEGIYCDRCKAGTIHLSASNPLGCQPCFCFGHSSTCTQGKWNKAQIINNIGWHLTDLTGGKDVKPEVENGEVLMFNANQNQDRSLYYWKAPDSFKGNMLNSYGGYLHYDVYYVPTEQGATVFVADVAIEGNGIKIEYHSRIEFLPREKMTVAIPMSELSGWYNAEARSPVDKADMMRALANVDRFTVRATYHQPQLQSSIFGLSLDTAVPAPDEIVEEDTSLKALAYHTQDTLMGGVEVCECPENFAGNSCESCVPGYRRVNNQLYGGRCEKCDCHGNSEECDPFTGECLNCRHNTTGSRCELCKPGHVGNPSRGGELGACEQCECPSLDLNPNPECISTELAVLGSVASNEDNYVCINCPLGYEGNKCEYCSDGFFEDPLTGKCIECTCNGNIDPMGIGNCDSETGKCLKCIGHTTGDSCESCKEHHWGNAQLHTCKPCGCHTQGAVNPQCSEENGECECKENYIGAQCDRCKENHGDVENGCPACDCNDTGSIGSDCDQVSGQCNCKQGVFGKQCDQCRPSYFNFTDAGCQFCHCNIYGSIEDGKCDQTTGKCECRENVEGTMCEKCADGYFNITSGDGCEDCGCDPTGSEDVSCNLVTGQCVCKPGVTGLKCDSCLPNFYGLTSEGCTECEPCPAPGQVCDPIDGSCVCPPNTVGEMCENCTTNAWDYHPLNGCKLCDCSDIGSDGGMCNTFTGQCKCKAAYVGLKCDLCTHGFFNFPTCEPCGCNAAGTDPLQCKDGQCLCNEIGECPCKKNVHGTKCDQCGEGTFSLDSSNLKGCTECFCFNRTSNCEQSDLVWQQMYAEDRRAVFQEPWEFYTKKHNINLLREKPSHFNSYPTDATPLYWPLPSTMLGDRTASYNGFLRFKIWNEDNRRGLHGIRPDQQYFRHFPQVIIFGNNRIELEHIPMEINDDGIYKIRLHESEWRVRHSPELTLTRKQMMVALQDTQGIYIRGTYTYPARGDAINIQEVSLDVAVPESKIVAGLSTTKAIGVEKCLGCPQGYTGLSCQNPEVGYYRKKHREYLNQADDIALIGWSEPCSCHGHSQTCNPDTSVCTDCEHNTFGDFCEHCLPGYIGDAREGGANACTKCACPLVENSFSDSCVAVDHGRGYVCNSCKPGYTGQYCETCVAGYYGDPQHIGGTCSPCDCHPDGSLHGACNPLSGQCECKPGVTGRTCSMCQERHAFINRVCTSCDQGCYLPLMETMDTMEEHLGRQNFSGLKPIPWKRVWRIGNESQDLSTFVGGIDKDGEIVKDSKWAKDAFALLDEVNFQMGRSNKSAVSIKQFTGIAEQLILDAQIHYANAFNTTNFLKMFAEHGATTVGGAALDGMLMEAEAHLNATVERGEYVEKRLNRAQQEHKKAEELLKMVTAQKLNETIFEDLKNRIDVLEQWMNDYRETIYDVSKKDTADAERMSLVVGKRINRYKEVSNEIEKLRVEAEDQIAYSRNSIEKARSEELMNMFEDKEKINMTLAELPDLVEQCQNITLLYSQLIDEYDEEYVQTAGRHAEKLEVQAQKIVDRFVDTRTETENPLKASHAYENIVEALKNATEAVDSAAEASEAVSKMLGSEGSESGDANEESLRSQLEKLKNESSLSNVDNSNAVKIVEELKKEKKDLTDRLGHLNELKTSIVKRLGVIKNEASSWDDKHDRMHSILKNGAKTAHERSANVKKESEGIKTEVSAIKAEVEKLMNSTSSGVQEDMEKIRASRTGMEYGAQKLTKVNKLSTANQGRTDKMARNIAILKAKIEQAREKAYQIRLSLNSGERGLCKRSYISPASPSPVNTFHVSYRPLQQVSDAVILVSKTKGRRTQPSEHLAVEIRDKRVVVHWDIGSGKKMITNSHPINYVPSNDRVTWYHIDVLRIGNAVNLTVALKESYDGGFKPRGAPVSVFVGNSKDDNSIFNTIPGETTIDVGTDETVASDIGLTTHKFSGIVGGLRIDEVPLPLWSFESTTGECEGATSPPKTSQRGHLFRDGFANVSMSVSERTMSAITVIFNAFSPNGLLYFRGSEASGDFVAIYLNDGKVMFKINLGGGSVAELTSQNVYNDGKEHTVKAIRTGSEMYLQVDSDADRFNTVITGENTALNIENENHYVAGVPMTLNKEVFGDINWNGFIGCILTVKPSQVGELDLDHPEHSQGKTDGCSQVSGVTDKIIGFPKPGYLITKGISIDNSSTFAFSFRTREENGTLVYQSSKLQKVSKRDSEDDGKGYIAFYLFRGYLVLHFGKDASSRKEVVTFRSSHPYNDGQVHAVFMERNGKIISVKVDDKEIGDSQSLSDETSVGTTSGRLILGGFSDDLKPPNNEIPITSFFIGCISDVFLNMKRVSLAPEKHNAQIGMCSMDDTQGLSPIDDPIDGNGHNGHRKSSKLSFEATNRNYYEVSTQSSHLVMNPNGEETVEKTCETSLGSLQGAVRYGLSKSSHSRINFEAPYPNITDFTVKLSLQTETSNGMIWAWANYKNYTRYIFLDIIDGFATLEVKGHKQPKILKHLGNRINDGQWHDITVEKKNRSLKLIIDSLGPVEMTDCPTPKVMKKRVYVGGVISRHRRQFGLTTPGLDGCIRDFEMNNRIFNNLDEPSTSKNVMPCAKACKLKRSSKRKRNSKN