lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton. Cell junction, gap junction.
Sequence:
MKQEITLSSQEQRIVQILLHSVVVISDSCNVFFCLHIIAVIINLMMIPLWAGHSTFFPGANMAAKRSASSSGAKDRLRSRPMASKKLPGEPSSSSSSLLTTKRSRSRVAEAHLPKSKSDTQIMAADRSSLEAALKAKEAEILRLRGELRGKAEPLSGQSGASSEGAEVPAQAEPEAASIREELARLKSENRMLKDRLNALGFERMTPSAEGSLEDLLGHHSQDNSESSEAYHPLTSSDDALDAPSSSESENGGNNNSNENNELSLAGLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSENERLGEEKLILMESLCQQSDKLEHFGRQIEYLRSVLDESEVGYILEGDLKSNRYLELEQRYVDLAENARFEREQLLGVQQHLSNTLKMAEQDHAEAQAVVSALKERVHLAERALEAEREANAALALALEECRAGRDGERAELARTEAALEAEREKLAELYALHRGGMEERDIRGLLEGARAEKEEAQAQAAQAKEERERAKAEAARSHEQHRALKLNHDLLATDLHNTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGELKRRLHEAQDKGEKLAKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSSSSSSANTLIKSFDSASASSAPGPSPSSSSASSMPRTPLSPSPMKTPPAAAVSPMQRHSISGTISSPKPLSDKRPAFTEIPTQGTKGIHNISNNCNNCLSLPASSRRSSEEMKRELSAPDGPASSSAANPSPSPTASVTPTTRSRIREERKDPLSALAREYGGSKRNALLKWCQKKAEGYQNIDITNFSSSWNDGLAFCAVLHTYLPAHIPYQELNSQDKRRNFTLAFQAAESVGIKSTLDINEMVRTERPDWQNVMLYVTAIYKYFET
The following text describes a protein:
Function:
Accessory component of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Functions with VMA21 in assembly of the V0 complex.
Miscellaneous:
MISCELLANEOUS: Present with 12764 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MVFGQLYALFIFTLSCCISKTVQADSSKESSSFISFDKESNWDTISTISSTADVISSVDSAIAVFEFDNFSLLDNLMIDEEYPFFNRFFANDVSLTVHDDSPLNISQSLSPIMEQFTVDELPESASDLLYEYSLDDKSIVLFKFTSDAYDLKKLDEFIDSCLSFLEDKSGDNLTVVINSLGWAFEDEDGDDEYATEETLSHHDNNKGKEGDDDILSSIWTEGLLMCLIVSALLLFILIVALSWISNLDITYGALEKSTNPIKKNN
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MGGVDSEGSHTPRAEGLCQERQGLQEIRETGTAFPTMAEVVAEVAEMPTQMSPGAVEMSTPMSGEMMEMSTEVTEMTPGEALASSLFFQHHQFMCSECGSLYNTLEEVLSHQEQHMLAVSEEEALTTQNVGLEPELVPGTEGPFQCGECSQLILSPGELLAHQDAHLRESANQIQYQCWDCQELFPSPELWVAHRKAQHLSATVAEPPVPPPLPPPTPLPPPSPPSEVKMEPYECPECSTLCATPEEFLEHQGTHFDSLEKEERNGLEEEEDDDEEDEEDDEETEDEEAMAEVGDDAVGGDESTASWAQGCGDCPQHRPSAGARRQHRRTSHSPASAAHPFHCSQCQRSFSSANRLQAHGRAHVGGTHECTTCSKVFKKAASLEQHLRLHRGEARYLCVDCGRGFGTELTLVAHRRAHTANPLHRCRCGKTFSNMTKFLYHRRTHAGKSGAPPTGATAPPAPAEPTPPPPPPAPPAQLPCPQCSKSFASASRLSRHRRAVHGPPERRHRCGVCGKGFKKLIHVRNHLRTHTGERPFQCHSCGKTFASLANLSRHQLTHTGARPYQCLDCGKRFTQSSNLQQHRRLHLRPVAFARAPRLPITGLYNKSPYYCGTCGRWFRAMAGLRLHQRVHARARTLTLQPPRSPPPAPPPPPEPQQTIMCTELGETIAIIETSQPLALEDTLQLCQAALGASEAGGLLQLDTAFV
The following text describes a protein:
Function:
Regulates the expression of 12-16 transcription units involved in various steps of sulfur utilization. Represses expression of pfkB, fliZ, cysE, ydcO and its own expression. Activates expression of ypfN. Acts by binding to SutR boxes.
Sequence:
MENLARFLSTTLKQLRQQRGWSLSRLAEATGVSKAMLGQIERNESSPTVATLWKIATGLNVPFSTFISPPQSATPSVYDPQQQAMVITSLFPYDPQLCFEHFSIQMASGAISESTPHEKGVIEHVVVIDGQLDLCVDGEWQTLNCGEGVRFAADVTHIYRNGGEQTVHFHSLIHYPRS
The following text describes a protein:
Function:
Possible regulatory or functional link with the histocompatibility cluster.
Sequence:
MHQAARAIPFSAKKKKAQLQDKRQRKRDKVAVSNTPVSDTCGVCKDTLLNRVDRDDTYNEEQKEREREPDRSTDYSDGRNSEGHPLQQSRQDSHGCIPTQTAGTVSHPPVSAHSSIYCCRVTSRQEHLQKESSESIQESKEIESVDARSAAHCHSPARNSSGRNASHVHQEQTRTKITPCISSTDSRIPYSSKASHFESVFAKVELDAIQAMRLASQSPITPLPQTVLEIGFEDLYPSGDMIDFPKRPHWNHSDSKETLEKRESEYFKWWLDGVNRRFDPDSLGYFEQNLEVWRQLWRVVEVSFTTSHSTFPTNPVQLYRSGNEAYSYIGVQQVPAPILAAWKEYFQNRYSGIHIVEFSCYSRDVFNVQDSMQGTLIKGKQPKSKRYAHAVGALQIIEECSKVKFDKNGIEINWAELMDQMQKDINKREKQASDVIERKECTESFLGRSRRRQQVPKSVSITCIQDTDIENDASKSKESFQLDLGQENQSISESITSRADLITIGLVGHPNVGKSSLINGIMGRTVVPTSKTPGHTKHFQTLHLSKRIRLCDCPGIVFPLKISKPAQILAGMYRIAQVREPCSVISYLAERIPIPDILHLKPPAYATFDKSINKTLAQSQATFLWSGWTICEAFAIQRGFLTSKTARPDVHRAASMLLGMVNYGKLLLVYRPSNFSSMHINLDFQNWQKLHHTSVSNASGSKGTRNGDLSKANDAQSLIECIHETQDEASPCTQSIAHLNSFAFLTDTTE
The following text describes a protein:
Function:
Catalyzes the conversion of 5-phosphoribosylanthranilate to l-(O-carboxyphenylamino)-l-deoxyribulose-5-phosphate, which is the third step of the tryptophan biosynthetic pathway.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MSTGISTDLHVHFGALNFSKTYKSGLSNRTVSFSRVGYAQNRKLSCSVSNTENVAPKDDERGKDRPLVKMCGITSARDAAMAVEAGADFIGMIIWPHSKRSISLSVAKDISKVAREGGAKPVGVFVEDDENTILRAADSSDLELVQLHGNGSRAAFSRLVRKRRVIYVLNANQDGKLLNEVPEEDCHLADWILVDSATGGSGHGFNWAQFKLPSVRSRNGWLLAGGINPTNVSEALSILQPDGIDVSSGICGTDGIQKDKSKISSFITAVRSVHY
The following text describes a protein:
Function:
Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.
Subcellular Localization:
Nucleus.
Sequence:
MFYFHCPPQLEGTAPFGNHSTGDFDDGFLRRKQRRNRTTFTLQQLEALEAVFAQTHYPDVFTREELAMKINLTEARVQVWFQNRRAKWRKTERGASDQEPGAKEPMAEVTPPPVRNLNSPPPGDQARSKKEALEAQQSLGRTVGPTGPFFPSCLPGTLLNTATYAQALSHVASLKGGPLCSCCVPDPMGLSFLPTYGCQTNRTASVAALRMKAREHSEAVLQSANLLPSTSSSPSPVAKPAPLDGSQDKTPPSKEQSEHEKSV
The following text describes a protein:
Function:
Involved in spliceosome assembly.
Subcellular Localization:
Nucleus speckle. Nucleus, Cajal body.
Sequence:
MAAELAEMRAQLAQVEALILAEPDNAEYQALASNIKQLIALQSQVAGVTAPADGDASGADGAKPKTVDGWTVGQECEAVWSDDGKYYKAVITAFTDDGLRAMVTFPEYEDSDEVKLASLRPLGGAGSGPSAKTGPKSKVSTGAAGDAPVTASSEPLKKKKKSYEERKKHEAKRRAKETELEKAYNDKANSWKNFAKKSKKKASGVGGSGKHGQSIFKTPDSYDGKVGVGTCGIGGKGMTSFTNRGKWQFEKE
The following text describes a protein:
Function:
RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
Subcellular Localization:
Nucleus. Nucleus speckle. Note=Colocalizes with splicing factors SRSF1 and SRSF2 in speckles.
Sequence:
MAIPGRQYGLILPKKTQQLHPVLQKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD
The following text describes a protein:
Function:
Hydrolyzes cerebroside sulfate.
Subcellular Localization:
Endoplasmic reticulum. Lysosome.
Sequence:
MSMGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEVVSMAEGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRGVFAVRSGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCQPGCTPRPACCHCPDPHA
The following text describes a protein:
Function:
Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTEPTLNFHIQTHQNQFKIPHELIKKNFKLIQKLIEKQRKQLIDDISKIKKCKTTSPSFKLELIQKLIKNFESFMKKLQNFINKDEEFRSRLIARLENLTELQQYVITNNDNQEGQNHEESTENNNNNRNNNNNSTTTDDDKLLDFHNPNLINWYRDQTNLLIVDYLIKSNTRTRFEDNGEDNPGNIGLLLLKNLTKTNPKLLKLIDYDLLENFNKVFVSIINNHDLSLIVGWFNENKNLLNKINSNLEFEINYCKFLTLIEKGDINEAINYSRENLSGYGNKENYQQTNNNNNNTFSNGDTTSTNHLTNLERLKGLGGLLVFRSMENNNKNNNDLNSNDTPLSSKLMLNSTPFKEYQKLLSNERWESLAQCFIENFTKLYGISKNFPIYIYLSAGLSSLKTKSCYHNVENTIFKHSTGNGIDYDNGNDDYDDDDDDDDEGGVIDSNLSFISAETTTNTNTTSNSGKSLLNDPKYRGPNHYYKLLNKINNCPICSPELFKLSQNLPYAQLITSIFNNPFKLPNGNIYPFDKLLAPTDKYLSEKNTLLRANKVKDPLTREIFTIDSCIRVFPA
The following text describes a protein:
Function:
DNA-binding zinc finger protein that recruits chromo domain protein rhino/rhi to specific chromatin regions enriched in H3K9me2/3 histone methylation, mediating piRNA (piwi-interacting RNA) biogenesis. May bind to GC rich DNA sequences including a 5'-GRGGN-3' sequence motif. Nucleates rhi/rhino accumulation and stabilizes its expansion. Involved in piRNA transposon repression, particularly in the female ovary during oogenesis.
Miscellaneous:
MISCELLANEOUS: Kipferl is the Austrian name of a traditional breakfast yeasted bread roll common in central and eastern European countries. Its crescent shape is reminiscent of the redistribution pattern of rhino protein in the nuclei of kipf mutant nurse cells.
Subcellular Localization:
Nucleus. Chromosome. Note=Localization along chromosomes matches that of rhi/rhino.
Domain:
The ZAD domain is required for dimerization; Possesses 2 arrays of C2H2 type zinc fingers. The first, consisting of zinc-fingers 1-4, plays a major role in DNA binding, while the second, consisting of zinc fingers 5-7, only has a minor contribution. C2H2 type zinc finger 4 is required and sufficient for interaction with rhi/rhino but is not required for DNA binding.
Sequence:
MMHSAKNVCRTCMDETGTLVDIFANVRDPVLDEPEMSLSHILARCTERPVKRGDLLPQFICVSCVLAVQNAFRFKWQSEQSYQHFFRVLNQSGAPENQVHLAACNGDKNQIINQKMQLKSDRQQDTQQMTKTQKPDDDLSQKQTLQAKLQEGNIDGPPESFTLHPRKRTCRTEEQADMIPKEATRSTKMICDADGYYNCPHCSKRFCSQTQLRTHITDLCNRCPYCPRTYMQKSNLKRHLRNHLSKPAHKCFHCSKAFMRKDHLKRHLRTHDSDGPLSCSQCSAVFIEHVQLEIHRREHKQRPGSSKSESTKDPDSDDSDQAQDLKPKWTKNTFNGTCSIPPMLKPKPICDICQKKFSSVYALKRHMLTHNRQHHLKKCTYCSEEFKTEKHLKRHERGHMGDLFRCEFCSLVFVDVNYLRKHKKRIHSNNVIAM
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Nucleus.
Sequence:
MGVKGNDGKAAKSKLSHQVVIICAIALLFVAAVKTIGSAPWHSKAVVREEQHINWLRDNTSSRQSADSVIEDSSASEESNFIQFEFSNLGGVEGSTGIVVVELHPEWAPLGVDRVKSLTAASFWEGCRAFRVVPNFIVQLGINGDPATQKQWASKKIEDDPVKKSNERGTVTFAMAGKGTRTSQLFFNTGKKNGFLDKEGFAPFGAVISGMDVVDRIYDGYREKPDQGKIQRKGNEYLEEYFPKLSFISKARFIARDTALS
The following text describes a protein:
Function:
Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex. Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes. Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (By similarity). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein. Note=Associates with late autophagic structure. Recruitment to autophagosome membrane is promoted by autophagic stimuli.
Sequence:
MVSQSSGRQDSPVDPWEGVSDDPGNTDGLPSLLDTEHPFCPSDIRFTRHRAAWINPPCAQQQLQDASPQVLAVGNRESHTASNTKSPLGTSPLSLGDSVVETSLPKGTTDSLGSSSAWGTAGNGSDSSVTLKEERAGLPRRCPHTSLITSSKTVSGPPCPEDGRAFFKPSQLTASADADAVQVGGRTVSSNSFSPEAFVLPVDAEKENAHFYVADMIISVMEKMKCNILSQQHTETWSTEEAGRSLGNSRADLEGTFYTHVKQESGSSTSSDSGYEGCVLQVSPVVETPTFSEVTEEDCKCDFDDFVIVELGDFSNTTEPCGCSSDTSKSVIHEPNFNSAELIAKELYRVFRKCWMLAEVHYQLTGSLDAAGSIVINEERVQKDFESSTDVVQEIKLKSRIRGTGDWAPPRFQIIFDIHPPLKRDLVVIAQNFFCAGCGTPIEPKFVKRLRYCEYLGKYFCDCCHSYSESCIPARILRMWDFRKYYVSNFSKRLLDHIWHEPIFNLLHVSHGLYTKAKELDRVREIQEQLFHIKKLLKTCRFAESTLKEFEQLPGHLTEALHLFSLEDMVKVKKGLLAPLLKDILKASLEHVASCELCQGKGFICEFCRSTAVIFPFQTATCRRCSACRACFHKQCFQSSKCPRCARITARRRLLESLPSAAT
The following text describes a protein:
Function:
Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDDLVFAGNKALYLVLILSGWPTIVATIIGLLVGLFQTVTQLQEQTLPFGIKLLGVCLCLFLLSGWYGEVLLSYGRQVIFLALAKG
The following text describes a protein:
Function:
May be involved in 20S pre-rRNA processing.
Sequence:
MAGAAEDARALFRAGVCAALEAWPALQIAVENGFGGVHSQEKAKWLGGAVEDYFMRNADLELDEVEDFLGELLTNEFDTVVEDGSLPQVSQQLQTMFHHFQRGDGAALREMASCITQRKCKVTATALKTARETDEDEDDVDSVEEMEVTATNDGAATDGVCPQPEPSDPDAQTIKEEDIVEDGWTIVRRKK
The following text describes a protein:
Function:
Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAPSRANTPSDDELDNILNGITEGRDISGTQAESTRPAYASKGSGNAGDGLGIDEEIIITKKRIPIPKLDDNRLLSDPGIPRLRRISKDRLRFKGKGHEYGDIARMLNMYQLWLDDLYPRAKFADALTIIEKVGHTKRMQMMRKEWIDEGKPRRTSAYEEEDADEVVVQAPTTEQATESMEGVEQGEEGAERAGPDEDELDALLAESAQQNTSAPKTLPVRTAGGEDDPFADEMEAMVDMEDMW
The following text describes a protein:
Function:
Transports riboflavin into the cell.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSIKHHPLQGALWMLTAGLAFAIVNSVAQYASIQFGLPSTTVALVQYAIAIVVILPYLKTLGIRQSLRTQQFGWHLLRVFLAVIGIQLWLWALAYPVPIWQGIALLMTSPLFATIGSGLWLREKVGMARWVATLTGFIGAMIILEPWADDFNLASLLPVGAAFFWASYSLMVKKLSSHDSPSTMVVYLLLLITPFNLLLALPDWQMPNGQTVWLLLIGAGVMTALAQWAIAKAYAVADASFVQPFDHAKLPLNVLAGWLVFGWVPPGRLWLGAAIIVLSVAFITQWETKKSRRERNIA
The following text describes a protein:
Function:
Defense against chitin-containing fungal pathogens.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MEFLGSQMVLCCVFWLFLTGSLAQDVGTIVTSDLFNEMLKNRNDDRCPAKGFYTYDAFIGAANSFSGFGTTGDDTARKKEIAAFFGQTSHETTGGSLSADGPFAGGYCFLREGNQVGSGFYGRGPIQLTGQSNYDLAGQAIGQDLVNNPDLVATDATVSFKTAIWFWMTAQGNKPSCHDVITGQWTPSAADTSANRQPGYGVITNIINGGIECGKGQNPQVEDRIGFYRRYCTILNVAPGDNLDCYTQRNFAEA
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MAELNVEIVAVDRNIWSGTAKFLFTRTTVGEIGILPRHIPLVAQLVDDAMVRVEREGEKDLRIAVDGGFLSVTEEGVSILAESAEFESEIDEAAAKQDSESDDPRIAARGRARLRAVGAID
The following text describes a protein:
Function:
Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly.
Subcellular Localization:
Nucleus, nucleoplasm. Note=Granular component of the nucleolus.
Sequence:
MAETLEAVEDAVDILEKEMLSFCNLIPVNSWGFDDDVKESLKMRKHSLVNRQLSKKERKSMSAQQKQHLAKGLGLVPNTVQEVLEWMSKSKQHSKVQPQKVVAPVKRPADQNKNKEKVVKKDQKKQDKKADSDSEEDDSSDDEEKEETDEPVAKKQKKEESSDDDEDSEDGEEPEGNNGAVEAEDSDSTDEEEETPSKPNKTVAQSTLKSNGKIDKEIQKLEDDEDNESPEIRRQIALLRLQKKLKEMKVERKGKGPAKVTSAMAEKMAEEKRLKRRESKLKLKQRRAEEKKGKEAAAQVKKETVESTENGNEPVEKQKSGISFNNLKFEIKEDKQRGKKQRTAKKDRALKLTGRDYKSLIAKVEETKATIAKVREADPHKATIMEDELKWEKTLKRAAGGKVKDNLGMLKKALVKKNKMKDRRKQKWENRENKTEGEKQTKQDKRKKNLQKRIDDVKKRKMNKLRNKGRIL
The following text describes a protein:
Function:
Lacks protein kinase activity.
Sequence:
MTPSLSLGQRLDDRYLIQLHLGQNSLGQQYLAQDTHRFDEPCTITVLTAPPGDKAGNLFKQQAEILYALDHPQIANFREFFALGSELYLVQDFIEGQSYFDLLKDRRLQGKAFTELEVRQWCRQLLPVLHYLHIQKICHGQISPSSIMRRTVDGLPVLVDFTHSQYYSGTPGEDRRDLHGLGLGAIALLTGEVNPNPPWENLLSSVALSQEFRQLLLKLLAWPPLVDWPTLTDNLNNLPQHFLPTVAEFNLTSTIPEQTDNGVGKSSTGEPPFPTVHQSPESSSSAKVKNMVRVDGLKGLVKKSFILLGLMAIAMALGWGAGQLWLDNQQRAALEKLAQEEPGDDVPEKTDLEIKNEIRARRLNLGISPQRFQTLMDDGLAFQLGIDPQQRLEKNPNTNGAPLSLGSPEQQMAMTITVLDALESLSREATRDFAQNNSGDRRRWIPRVNQLRLSSRSFYDLVNARFHHYLPMVSPALLGEPEFEQRPLAQVWNAMAFDSLASLEDESHYQRLSFDDTNQLNLNGTLEPGEGYAYAVTIPPTEEFSLQLTAPPTARISFYPPTGPEVILQNSAMHRWSGPTDQAGYYELVITSVAEEPIAFELELSIIPASAQPF
The following text describes a protein:
Function:
Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Subcellular Localization:
Mitochondrion.
Sequence:
MHRPARGALRISTRLATRPPLPALIHSRPYSLSATEPPPNLQPHQYPAFERLSTALSLKQPCFGARGDEVELLTGPEVFYSRLLDMIKGAKRRILISSLYIGAEEGELVEAIQAALTNNPQLRVVFILDYHRATRLATSTNLPPSTAHLLLPLVERFSDRCEVWLFRSPKLKGLMEKIVPARYDEGWGTWHGKWYGADDEVIISGANLGRSYFTNRQDRYIHFRSNPSLLSYLSSLTRLFTQYSYLLHHSPPPHIPPYNTVPLPSPENPDNSKLPSSSVSIRPRASLIWPSSSINPRKFSLHALATLSAFQNSWRASNSARSRRVDVDTWFWPVLQAGVLGIKEEERAMAEVWKAVRESHEGEQNESRKVEVDLTSGYFGLYKKYKQLVVESPASVKIIAASPKANGFYGSKGFSRLIPEGYTLLETRFHRDTVRAGRTWNVEKGTGVRLKEWEREGWTYHSKGLWVSPPDSKPFLTFVGSSNLSTRSLTLDTELSMVMMTSSPTLRRALDTELKHLDEYATQVGEETWKLEERQVSWLAWLLVALGVEGML
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Sequence:
MSAAFPSVRAVCRPGSFAGEKRGPPPAAASGKLASGFLGSAWKLRFGALPARRRGSSSVVVAVSDVVKEKKPKRSSSSSSDLLITKEEGLELYEDMVLGRTFEDMCAQMYYRGKMFGFVHLYNGQEAVSTGFIKLLKQEDCVLSHYRDHVHALSKGVSARAVMSELFGKTTGCCRGQGGSMHMFSKEHNLLGGFAFIGEGIPIATGAAFTSKYRREVLKEADCDHVTVAFFGDGTCNNGQFYECLNMAALWKLPIVFVVENNLWAIGMSHLRATSDPQIWKKGPAFGMPGVHVDGMDVLKVREVAKEAIGRARRGEGPTLVECETYRFRGHSLADPDELRDPAEKAHYAARDPIVALKKYILESNLASEAELKAIDKKIDEIIEDAVEFADASPIPPRSQLLENVFADPKGFGIGPDGRYRCEDPKFTEGTAHV
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDHNILKSIFLIGSPFGLCQNKFYKLFAIGFFLLYNVGIIVKFHARQNSSYWTLSSMQFVLRLLLNCDLYFHNFYVFIIVGITKRNQLTRLVTNIKKIKLGGLSQYHCVFFGWYITMVAVLSLNFYIWWTCFKFDFIRFYLIEYFEMYTQFFFILSACIILRMLLFRYKYQKQLILEESVMKQITSLNMHDIEINLVILKRTDSTFNEIFGWTILYNIFFAAIKTLIYLDIAVKNYSTLVTHSTSQFVSQITLLLLFWICIIVVIRFCDSIIEEFEGLISLAYRFENCDLDLIIDKNEICEFIKNVSQNRPKFTAGRYFVIEMTLIFNILDSMTTFLLIVLQFKEN
The following text describes a protein:
Function:
A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSEKQMKEAFVSNLNGTTVLEITQGLCFPAFCILCRGFLIIFSQYLCSFSPTWKTRFLIDFVVLIVPMVATLTIWASFILLELLGVIIFGAGLLYQIYRRRTCYARLPFLKILEKFLNISLESEYIPAISCFRVITSAFTAIAILAVDFPLFPRRFAKTELYGTGAMDFGVGGFVFGSAMVCLEVRRRKYMEGSKLHYFTNSLYSVWPLVFLGIGRLAIIKSIGYQEHLTEYGVHWNFFFTIIVVKLITPLLLIIFPLNKSWIIALGITVLYQLALDFTSLKRLILYGTDGSGTRVGLLNANREGIISTLGYVAIHMAGVQTGLYVHKNRSHIKDLIKVACFLLLAAISLFISLYVVQVNVEAVSRRMANLAFCIWIVASSLILLSSLLLGDIILSFAKFLIKGALVPCSWKLIQSPVTNKKHSQSLVPEAERMEPSLCLITALNRKQLIFFLLSNITTGLINLMVDTLHSSTLWALFVVNLYMFSNCLIVYVLYLQDKTIQFW
The following text describes a protein:
Function:
NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability.
Subcellular Localization:
Nucleus.
Sequence:
MDLASAPRGESPPLKAPLVEIEAAEVERSLPQENAAPEEKGSNSQSEYESDSDALDDEWETQSLYEDAIQMIRDDQLRDGTIPGACTLEEAIEFRKRLHEVGKAQFVEETIARDTVTAKKLCTAFGILPPSFLEGAPDEAYHPLLAIAISREFARRQKLPQYNSVDDAVKLLKESKNIIVLTGAGISTSLGIPDFRSKDTGLYSKLENLGLNDPQEVFDIRIFREDPGIFYSIAKDILPTEKKFSPTHGFIRLLQDKGKLLTNYTQNIDNIEANAGVFPENIVQCHGSFATATCVKCQYKVAGDEIYDDIKKGLIPECAQCRKRIAEDSQKPQGQKRKRNSTSAHKDRSKSGEDSSDGEDYEIPTPGVMKPDITFFGEDLPDEFGRRLLHHDRDKVDLVIVIGTSLKVAPVAEVPGVLPPHIPQIYISRTPVAHTNFDIDLLGDCDVVVSELCRRAGWELKHEMISPDEKVDVTPVFGYGSRHVFKVSG
The following text describes a protein:
Function:
Peptide hormone that functions as endogenous ligand for the G-protein-coupled apelin receptor (APLNR/APJ), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis. Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR. Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs. On the other hand, APLNR activation induces beta-arrestin recruitment to the membrane leading to desensitization and internalization of the receptor. Required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis. Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating APLNR. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Positively regulates sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel sprouting. Plays a role in placental vascular development; promotes placental trophoblast invasion and spiral artery remodeling in the uterus. Involved in the regulation of maternal cardiovascular homeostasis to prevent gestational hypertension and for potent cardioprotective functions during heart failure. Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity).
Subcellular Localization:
Secreted. Secreted, extracellular space. Note=Found in blood plasma. Found in serum of pregnant mice, peaking at midgestation; indicating a maternal and zygotic origin of circulating APELA during pregnancy (By similarity).
Sequence:
MRFQQFLFAFFIFIMSLLLISGQRPVNLTMRRKLRKHNCLQRRCMPLHSRVPFP
The following text describes a protein:
Function:
Acts as a tumor suppressor; induces growth arrest at G(1)/S checkpoint and apoptosis via RB1-dependent and p53/TP53- and NF-kappa-B-independent mechanisms. Modulates expression of genes involved in the regulation of proliferation, cell cycle and apoptosis.
Subcellular Localization:
Cytoplasm. Nucleus. Membrane; Multi-pass membrane protein.
Sequence:
MYCLQWLLPVLLIPKPLNPALWFSHSMFMGFYLLSFLLERKPCTICALVFLAALFLICYSCWGNCFLYHCSDSPLPESAHDPGVVGT
The following text describes a protein:
Function:
May play a role in the regulation of insulin-dependent IRS1 tyrosine phosphorylation in adipocytes.
Subcellular Localization:
Golgi apparatus.
Sequence:
MASAVVSMVSTTASRFALLKVDSSSDSDSEKARGTHTSGKAHSGSAARGKTNVNEKKKEKRRKKKEQQQSEANELRNLAFKKIPPKASLGVSAAVQEHITHTVPKDAQKEDWQQWQQRDKQLTSDMFEADLEKALILSKLEYEESKVNGDGVNGVPQSKKVNKKDKRKNNQGKDKPLTVPLKDFQLEDQQAKKQEELKSPALPQGSGFFNKVEDDVTKIILNEKRKEHSTDVTESFATPEYSTEPALKDGKTEVLKQEIEKKEIALQQMRSKISQWEAKYREVKARNSQLLKMLQEGEMKDKAEILLQVDELLSIKNELTLQVTTLHAALEQERSKVKVLQAEQVRYQGGKKSKRNPELEHGR
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes. Also regulates the sphingolipid metabolism (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MICINCCCHVESLYVAYPGDHIRLTDCWQCGEVVDRYVEFDNVLLFIDLLLLKPGAYRHLVYNSLEVDMRRYPEHGTRESGFRGYVQDWLLWFRKYDRLNRIWLLLITFEVYLMWMTEEKKYNNYYREPATQYGWHLLTGDVLSLQNPLLQYLFFAVYVIGDLALLHKLTRESLLNWSQWGQDLRYAKDIVSYTILLSYGAKIFPILMLIWPYDSLVSTSIIKWIANFYIVESLRIVTSKSYSYIILLFAGIFIVRSVVLKPVLALIVSRGNMLQAQRYLWGEYELFKFRFLTKRDIFL