lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MKLCGVRGSGVSLMRSSNFPCFRAAHNGGAPTATRHQSLCGRCLDSHMGAGKRWCFRPLLAEPRRYGSASSASTTDAATAPVHGEDLYVSHYAIPEDARRLVGTPQLLPRNPAEEVAFKKNLIRSFPQACIRNVSVVAHVDHGKTTLSDAMLRFSNLLPADGATGTFTDRLKVEKERGITIKAQTCSVLLTVRETGTQYLVNLIDTPGHVDFQYEVSRSLCASEGAALLVDVRQGVEAQTMAQFYAALEQNLTILPVLTKMDNVMSDAEVEKTLLQLEDSTGLLSREVILTSAKSKQGIEQLFQQIIDKVPPPRGREGFSDMKQLPAMHPDSADRKKVEKELVPLRALLFDCWTSESSGMTDGAASAPVSTVSSVSSGTTAASGGQSVAKDGIYGLIRVMDGTVTPGTTVTFFHSGKKHEVREVGIIHPTLHPTAALTAGMVGFVFFPGLLKKDVFIGDTLCTLPTRKHTMRVVATGPPETASRTKPATAAETASSDDASGSSGSSVVEPIPGFKTVQPVVFAGFYPDEGVYITQLREAVDLLCVNDPSVTVEQLQCPALGPGLQLGFLGFLHMQVFKERLLMEFGQTVLVTPPQVQYMYVEQHGDPDDPAQRKPVSVSNWRWPHEGVGAYLEPFITATVLTPSEYLNEINSAALSAFRGEMQEMRVIDGARTLVRYRMPLADLARGFFSTVKSSSHGYATLEYDDPTYMTADLVKMDIVINKAHISALSTICLRHEATTHARRIIGSLKENLLRSSVDLPLQALVGSKIIARETVKAYRKDVTAKIHAGDISRKQKKWNDQKKGKERMARRSVGTVTLDQSVLAAALGATTAR
The following text describes a protein:
Function:
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEEKTPENEQSKKTFDPKDSMKIEETSTNGSSQPSQPSNIKLSIGSILESSNDNGDPEYSENGMGNMNMNTLPMATSTPMSYTKQPSEAKYPNSVWERKGVSDQEENTSSVKRQKTLPTQSSGEEEAKYSHPGAPTATSADSISMESRPSNLSTSLSKTTSYPQFQVRQFVSPIISIDNSALEPFLNRYPASESLFPVTEYEYTPWLEFPLLYSSIGKFVRVTIDIKWLNAAINPRLCRREIWGTDVYTDDSDIATILAHCGCFSLLKPVRKIAVVDLYILPPLVHYKGTRKNQIESRSWSSRQDGISLKIKEVTWKPACASIFENSIHTLTLEERLQARLELSRSSTFKI
The following text describes a protein:
Function:
Displays acyl-CoA thioesterase activity with short chain aliphatic acyl-CoA thioesters, such as propionyl-CoA and butyryl-CoA. Enzyme activity is relatively low, suggesting that the acyl-CoA thioesters used in the assays are not the physiological substrates. Has no detectable activity with 4-hydroxybenzoyl-CoA, lauroyl-CoA (C12:0), arachidoyl-CoA (C20:0) and arachidonoyl-CoA (C20:4).
Sequence:
MLDNGFSFPVRVYYEDTDAGGVVYHARYLHFFERARTEYLRTLNFTQQTLLEEQQLAFVVKTLAIDYCVAAKLDDLLMVETEVSEVKGATILFEQRLMRNTLMLSKATVKVACVDLGKMKPVAFPKEVKAAFHHLK
The following text describes a protein:
Function:
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLSINNKLKNLKLSTVKNLYNKSSSISIILVNNNNNNNNNNNNNNNNNNNNNNNNNNFISLSTTNLFNQKLCIESYKKVNYCKKKGGGNKNNDDNDNEKNEKNEKKVKNEKKEKNEKNDGNEKVEIVEDNDLIVPLSKELLQFDKPSNKRKDWPLNSEVVIYPSNSVNFIGTTGPINLGFQFITRLVPNASGKTFLGFFLCKDAYRNNNNQIGRTIDSIHNVGVLAQVTLSPSGIYHFETIKRIRIKEVQNGQFPFIASIEPLSNDERELKDPRIAELMTKINVLSLEYRKLYPDVYTINSVDFENQIEVIDNPDYYLAAVINYYGLNYPDECQKILETQSVVKRLEMLYHMILNEQPLLALQQKIAKDLDDKTTAYKNKLLLTEQLKKLKALLGNETDEKEKTIEKYQNKLSELTLISESSKKVIQDEIYKISTIDPSSSEYSALKNYLEWLTNLPWGIYSADYFDLKHSKMVLDSDHYGLEDIKQRILEFISVGHIKGTVQGKILCFIGPPGTGKTSIAKSIAKALKKEFFRFSVGGLFDESEIKGHRRTYVGSMPGKIIQALKITQTSNPVILIDEIDKIGKRNHGDPSSALLEVLDPEQNVSFVDHYLDTPYDLSKVLFICTANSGQDIPAALSDRMEIIRLPGYVEEEQIEIVKNFIIPKTFIDCGIKLDQLSISDDVIKQIVKFYSREVGIRELEKLIEKIMRKTALKLVNGTAERVDLTLDNLEQYLGIPSYTSDRYYDVTPIGVVNGLAYTKKGGATLYIESTSEEIQKPLSSLPPSQQQQNQLEPSIKTTGNLGDVMSESSTIAYTFAKNFLYELDPNNTFFSNHNIHLHSPQGNIPKDGPSAGVTMVTSLLSLALNEPVQNNLGMTGEVTITGKVITIGGVKEKTIAAKRSGLTSVIFPINNRINFEELPTYIKNDIDVTYANDYKDVFEVAFPNKKYLLNNLKTF
The following text describes a protein:
Function:
Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADPH, but not NADH, as an electron donor for its activity (By similarity).
Sequence:
MKGLIIIGSAQVNSHTSALARYLTEHFKTHDIEAEIFDLAEKPLNQLDFSGTTPSIDEIKQNMKDLKEKAMAADFLILGTPNYHGSYSGILKNALDHLNMDYFKMKPVGLIGNSGGIVSSEPLSHLRVIVRSLLGIAVPTQIATHDSDFAKNEDGSYYLNDSEFQLRARLFVDQIVSFVNNSPYEHLK
The following text describes a protein:
Function:
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKALFLVIFAYLLGSITFGEVIAKLKGVDLRNVGSGNVGATNVTRALGKKYGVLVFFLDFLKGFIPALIAVKSFGIDSWVLTFTGLASVLGHMYPVFFGFKGGKGVATALGVVFAVSPSVALFSFLVWLGIFLWKRYVSLASITATISAFLFLFVAGYPVNVLFMAIVIGALIIYRHRENINRLLTGREHRF
The following text describes a protein:
Function:
Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. Mechanistically, captures transport vesicles arriving from endosomes via the protein TBC1D23. Recognized vesicles are then tethered to the trans-Golgi before subsequent SNARE engagement and vesicle fusion. Selectively regulates E-cadherin transport from the trans-Golgi network in tubulovesicular carriers.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane.
Sequence:
MFAKLKKKIAEEAAIAPRPGGAARIPRSISKESITSVGADSGDDFASDGSSSREDLSSQLFRRNEQIRKLEVKLSDYADQIRNLQKIKEKLENALEKHQDSSMRKFQEQNEAHQANRAKMAEGMALALEKKDQEWMEKLSHIEKEKKMLETQLQEMRERSLNLFQKRDEIDELEGFQQQEMAKVKHMLLKKEECLSKAEQELEARTRELIHAKEMLQEASTESSGLRKDLHELQEQFLEVEARRDELMTAERNAENKITALELREQELQTVIQHLSVDLQNARVAGSGCEKRLETLRVEHESLKVEYEQHKLKMTFEFAERSKLIEQLQEKVSSLEKKLERNLSGDEHVQELLKEKASLEQKLDETSQQILTDRMDHANGMNQLETQNRELEEKLQIATEALKMSKEAACEQDLKIQKLQMDVENERSKLQQQVLSEKHQYEQKISELESQIAALQTAWEFDKTAAQHKISQLEKENENLNGSREEYESSLKKQESVLNKLKKELSSRETVNTEIANTLEETEKQKDKLQQQVSHLASLIKDKDRLIDEKSGMLLKQKEELNQLRQDHEAALLQMHQLRSDIEASNSQAVEKEETARKEIEELKLQIQEFLLAREHEKNVSELEESARGLNEHLHLPENCATEQNGEVTATDVIQLQKDNRELEQQIVEKNKMIKQLQQRMAELKKTLQKELKIRPDSEVPELREKTNSEVPNASVTVTNNSDLNDSREINFEYLKHVVLKFMSCRESEAFHLIKAVSVLLNFSQEEENMLKETLEYKMSWFGSKPSPKGSIRPSISSPRTLWS
The following text describes a protein:
Function:
Peptidoglycan polymerase that is essential for cell division.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKTKTKLGAIDFTLFVTITLLVSIGVIMVYSASSYSAFFNPNIKDSTYFLKKQGAFAIVGIVSMLFIIKIDYHKYKKHTKKLMLITIVLLLMVFIFQPVNGARRWIRLGPLSLQPSEITKYMIVMYMAKSLEYKGEKIKTFTYGIIPYLLVSGFYAGLVFAEKNLSIAAVIMIVTLIILYVAGAKTKHISLVMLMVLLAGVAGIIFEPFRVARFLSFLDPWKDPKNTGYQLIQSLLALGSGGIWGVGIGRSRQKCYYIPEPHNDFIFAIIGEELGLIGCILIIILFSIFIWRGIVIATKAKDTYGTILATGITSIVAVQAIINMAVVTGSMPVTGVPLPFISYGGSSLAINLMAMGILLNISRQTENTI
The following text describes a protein:
Function:
Probable transcription activator for a number of lung-specific genes. Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1 (By similarity).
Subcellular Localization:
Nucleus.
Domain:
Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.
Sequence:
MSTEGGPPPPPPRPPPAPLRRACSPAPGALQAALMSPPPAATLESTSSSSSSSSASCASSSSNSVSASAGACKSAASSGGAGAGSGGTKKATSGLRRPEKPPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYHRVVSGLGFGASLLPQGFDFQAPPSAPLGCHGQGGYGGLDMMPAGYDTGAGAPGHAHPHHLHHHHVPHMSPNPGSTYMASCPVPAGPAGVGAAAGGGGGGGDYGPDSSSSPVPSSPAMASAIECHSPYTSPAAHWSSPGASPYLKQPPALTPSSNPAASAGLHPSMSSYSLEQSYLHQNAREDLSVGLPRYQHHSTPVCDRKDFVLNFNGISSFHPSASGSYYHHHHQSVCQDIKPCVM
The following text describes a protein:
Function:
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MSHKFVIVGAGLSGLSNAFFIKHFFPKAQITLVEQSNRVGGMIISNNRNGFICEEGPRSIRMGKYNRPLYHILNKIGLYKEFVPSIQQPYSYIYWNGKLNAVPLQMNLETISQFVQDNGSGDVFKLIKAYPKMLFKKLDTDNLGDYLELVLGRDLTEKYAESVFYGIYGESVYNLSKALCYQKSHMKGYDEQQISKDLSFDKDFEQARDQKLKGANSYRFKEGVESLPKRMHAYLQETYESDYKVKLNSKAKCIDLSRKELVVESREEQEEQRLNYDYLILNAPTHQLSQIMINSNLNKVGEMFRGVKCNTLVTRNICWDQKILPKEFKGFGYLINPKQQQVILGMVADSLSFPSQYPENATNLSVMSIYDVNDHVILSELSKHLGVKIPDPKEIVTKSWSKAFTQFSPGHQEEMKKIESELNAKSIIIGANNYTLAIPELVYLSYSKVKQLYL
The following text describes a protein:
Function:
Emits blue light flashes with a wavelength of 475 nm during the night phase.
Miscellaneous:
MISCELLANEOUS: Dinoflagellate luciferase mediates much of the bioluminescence in ocean surface waters.
Subcellular Localization:
Cytoplasmic vesicle. Note=Localizes in scintillons, specialized organelles formed as outpocketings from the cytoplasm into the acidic vacuole.
Domain:
Composed of 3 homologous Luciferase domains: each of the individual domains are most active at pH 6.3, and there is very little activity at pH 8.0.
Sequence:
MAAQLEQFLVNEGQVDQRAVTYMLKGLQLESLSDFASFWTSKDYENGVRDDIISKVAPFNSDLSLPAAKLQVARLRAAWRKAQGKPSAAVPLQSAKPVAGSVVTATKDTGFCEKTGLESGGVAHGGALNAAQVAHLDEDAFKGGLHRPKFDSEGLHKPHTSGGKTYETGFHYLLEAHELGGKNADGGFGGPLCADPFSPEIEQLCQALVREAQDDKTLCFENFTKPCPQLTKKQVELCKGFDYGDKTLKLPCGPLPWPAGLPEPGYVPKTNPLHGRWITVSGGQAAFIKEAIKAGMLGAAESHKIMADTDHHQTGGMYLRINQNGDVCTVDASVAKFARAKRTWKSGHYFYEPLVSGGNLLGVWVLPEEYRKIGFFWEMESGRCFRIERRAFERNGLMIMRQATEVAGKISFVFYVKVSNDPESKPIPLQSRDYTALAGLDNVPDSLGNPYTCEAKDLDYPIKRDTWLDKNQEEMLKQRSIVGTAFAKCCDQGFEAHDNPKGGALTAAHVESLGKENFKNGLHAPNFHDDGLHKPMEAGGKVYSTGFHYLLEAHDLGGKNEDGGYGGPLCKDPYGKEVQSMVENLLVQANVDTTNAFDNFKQPCPQLTKEQVAMCKGFDYGDKTLKLPCGPLPWPAGLPEPGYVPKTNPLHGRWITVSGGQVAFIKEAIKSGMLGAAEAKKIIADTDHHQTGGMYLRINQYGEVCTVDASVAKFARAKRTWKSGHYFYEPLVSGGNLLGVWVLPEEYRKIGFFWEMESGHCFRIERRAFPCGPYMFLRQATEVGGKISYVFYVKVSNDPGSKPIPLQSRDYTALAGQDNAPDNLGKPYKCTARDLDAPTKRDGWLDTNKGAMLDQREKVSKAFAKVCEKGFEAGDNKLGGALNAKHVEKYGDNFKNGMHKPEFHEDGLHKPMEVGGKKFESGFHYLLECHELGGKNASGGYGGPLCEDPYGSEVQAMTEKLLKEADSDRTLCFNNFQDPCPQLTKEQVAMCKGFDYGDKTLKLPCGPLPWPAGLPEPGYVPKTNPLHGRWITVSGGQAAFIKEAIKSGMLGAAEANKIVADTDHHQTGGMYLRINQFGDVCTVDASVAKFARAKRTWKSGHYFYEPLVSGGNLLGVWVLPEEYRKIGFFWEMESGRCFRIERRAFPVGPYTFMRQATEVGGKISFVFYVKVSNDPESDPIPLQSRDYTALAGRDNAPTNLGKPYPTLAKDLDYPKKRDGWLEKNEKEMLRQRNIVSSTFRS
The following text describes a protein:
Function:
Required for assembly of the mitotic spindle.
Miscellaneous:
MISCELLANEOUS: Present with 656 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MIQKMSPSLRRPSTRSSSGSSNIPQSPSVRSTSSFSNLTRNSIRSTSNSGSQSISASSTRSNSPLRSVSAKSDPFLHPGRIRIRRSDSINNNSRKNDTYTGSITVTIRPKPRSVGTSRDHVGLKSPRYSQPRSNSHHGSNTFVRDPWFITNDKTIVHEEIGEFKFDHVFASHCTNLEVYERTSKPMIDKLLMGFNATIFAYGMTGSGKTFTMSGNEQELGLIPLSVSYLFTNIMEQSMNGDKKFDVIISYLEIYNERIYDLLESGLEESGSRISTPSRLYMSKSNSNGLGVELKIRDDSQYGVKVIGLTERRCESSEELLRWIAVGDKSRKIGETDYNARSSRSHAIVLIRLTSTNVKNGTSRSSTLSLCDLAGSERATGQQERRKEGSFINKSLLALGTVISKLSADKMNSVGSNIPSPSASGSSSSSGNATNNGTSPSNHIPYRDSKLTRLLQPALSGDSIVTTICTVDTRNDAAAETMNTLRFASRAKNVALHVSKKSIISNGNNDGDKDRTIELLRRQLEEQRRMISELKNRSNIGEPLTKSSNESTYKDIKATGNDGDPNLALMRAENRVLKYKLENCEKLLDKDVVDLQDSEIMEIVEMLPFEVGTLLETKFQGLESQIRQYRKYTQKLEDKIMALEKSGHTAMSLTGCDGTEVIELQKMLERKDKMIEALQSAKRLRDRALKPLINTQQSPHPVVDNDK
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.
Subcellular Localization:
Nucleus.
Sequence:
MEIQSQQQSQLKLQPKPSNPSVSKGSKFKGRNNNKVNKFVGVRQRPSGRWVAEIKNTTHKIRMWLGTFETAEEAARAYDEAACLLHGSNTRTNFITQAPSDSPLACRIRNLLNSKKGGEQHHHQSVVVSAAPSTSATISFSPMPSPSTSSSGCSSNGGLSNGNLSVSGRVQDTQLFDDAYKPDMRSWRRESGFDSDFTYTSSELGFDRFLYTQETTGLPEETGSELTEFQSMKVERQISASLHAMNGVEEYMETVHDSSENLWDLPPLCSLLY
The following text describes a protein:
Function:
Inhibitor of trypsin (serine protease). May protect the plant by inhibiting proteases of invading organisms (By similarity).
Miscellaneous:
MISCELLANEOUS: Has a single chain structure.
Subcellular Localization:
Vacuole.
Sequence:
MKCLFLLCLCLVPIVVFSSTFTSKNPINLPSDATPVLDVAGKELDSRLSYRIISTFWGALGGDVYLGKSPNSDAPCANGIFRYNSDVGPSGTPVRFIGSSSHFGQGIFENELLNIQFAISTSKLCVSYTIWKVGDYDASLGTMLLETGGTIGQADSSWFKIVKSSQFGYNLLYCPVTSTMSCPFSSDDQFCLKVGVVHQNGKRRLALVKDNPLDVSFKQVQ
The following text describes a protein:
Function:
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSLNPQYEDIGKGFVQQYYAIFDDPANRANVVNFYSATDSFMTFEGHQIQGAPKILEKVQSLSFQKITRVITTVDSQPTFDGGVLINVLGRLQ
The following text describes a protein:
Function:
Probable histone methyltransferase (By similarity). Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin.
Subcellular Localization:
Nucleus.
Sequence:
MHGAGEQQQRYRYNARSDEQHHHPSTSSHQYQQQGARQMHQMHPIQATLMCTPTTTSAAASTSSSGGSNSSGGSGGHRQQGNILRIGNSIKIGDNILEPAGTLVFSQADGTPWTGQRIVVNGSTHAVVKANLFPIGTTPPVLNMQSNQNWYMNQPSGTVPMSSNAPATTSSATPDSGIQSVPTSPPSPSYAMMNDVDIGDHDDEEDDDGPADFTDMPLLKPVDEDDDCYDVPCTSEGPPPNNSNPAITTIPSSCSTPAPPKESLPTGMNVEEWGSFLIASNMDREEIVRRLMAHDPEMAKAIAMRIRELSAEESKKKKDMEAEVSSTTPTTPRARGTRTRNKCATRSTNSPDVTTSNLPEEPSTSTMGLVKENEDVEKVEGKRRGRKPKKRRGFHKESFEDLESDAKKSKAEQHEDHLPEASCSSRPESVIPPPVDPIQFRLKVREMMERKLEQLTQKMSEDMTELRLSHLTSSKMVNGERGKRRESFLRQLNEQSKKLRKGGMLGRKRLRMFMTESDILEENKDNIKKEVKEESTPPPTKLRGRLPSRRTREPSEIVNPEPVEKKFNGEYFEITKSVPSSDDIIPLWMAPSLTCGCTKGACTSDMDCLNRALRVQCSSDCSVPYCSNRRFWKEDCGNKLCVSNGPRSKRVLKTKIARRAGEFLCEYAGEVITREQAQEKFAQDRDPRIIAIAAHLFVDATKRSNIARFIKHSCKPNSRLEVWSVNGFYRAGVFALSDLNPNAEITVDKSDLLPFDMACNCGATECKRVIRGVRWRCADPNEKIVTRRFVIRNRRKTIERSSHSGLPAILQTPMDENSSIRLKMKQVLAAFAFRVRKIDGSMSRTMLPHYTLIIKFLKTKGNNPNPVEFVSLFRKWLEAIDDDDLERAFVAIESHYMSSSILSSSLQSKKAKDNAPRARALSTSCPSPVPSKRGDADLSYLESLYPIGSYDPDDAWESYSTNKKGNAVRCICGALDEEGTMVQCDTCHFWLHVDCCQYVVRSNEKAQKSKNPPSDDGEYICDFCTNKQNGLRPSADVKLTEQPDVRFENCDYYRSLINRRGIQVVLNETVYVNRVLPEDHKAMLRNLREEKKGSKQKDTNKYRFPKAATSPLPIEKVDRKNARIFRVERLFVCPGNNRFVFGSFYAWPHETYADAGRVFSKKEVFATPYYETLPLDEVIGRCLVLDTATWCKGRPKVPKFKEDDVFLCEMQIGKTQRVFEKVPPKNRYPINTNSYVFTEFTHPKKVVRDFRPYDPSNPSPKPPKTSSIPSTSSIDPPQSSSDGLPEVDTKKLSKRHIQRVLKRLVKNGSRRS
The following text describes a protein:
Function:
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
Subcellular Localization:
Cytoplasm, P-body. Nucleus.
Sequence:
MDQPIVNIPEEVLSSLCTRFLINIPDEERNDLIRAFFQIELAHWFYIDFFRVEQQGLPNCGMKEFSKAIFKHCPFLIDHADKVDKLHAEWREYKMSVPTYGGILLDTSLTHLVMVQGFFSRTSWGFPKGKVNKEELPVQCAIREVREEIGFDVTNYIDENNYIETYLNDQLARLYVVPNIPMDVDFKPITRGEIKEVRWFLINDLPASKKDPAPKVNLGLNPNHFFMVIPFIKPLKKRLNKMQQSGSSNRGTYSPSAILSSNSNTQSQRTQSPTQGNYRQSGGRGRGGNNNHVVNTNGGPTSQTTPDSNKVETRRKQQQQSFKAQNMNAITQYSRFKDPALDAMWNNQGGVGLKQRQKSQGGGGQGVVVIHPRHRSHRRKLQNKGDIARSEFMTLMLINKIQRLFKDPPHFRASKSIANRRRIAANPVTPSALKHSSTSGSMSMPS
The following text describes a protein:
Function:
Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Secreted.
Sequence:
MALSRINSLLIFCLNLLLLLHVKKSFCIGNDTECFSNPCPNNSTCDDAGKDSTCHCSGTTENVGEDCIKKLVSCSSKPCKRNGFCFDLDEEPGFLCRCPPGYGGKHCEITFTSCVSGFCRHGGICHEGTSGPFCDCPDGFIGKHCETDFNECASNPCRNGAVCQDGINGYSCFCVPGFQGRYCDREVDECVSNPCYNGAKCHNKVGSYICDCLPEYFGTNCEFEIDQCLSQPCLNGGTCQDSVGRYFCDCASGFRGEHCEINTNECLSQPCLNQGKCTDGYNSYSCNCDDTGFTGTHCEISLSVCSSKPCHNNGTCEEFDDTFICHCWPGFTGSQCEIDINECSSNPCLSTGECVERSWASHYGKIPELPSEFNYLQATGYVCHCQPGYTGSRCEDDIDECSSNPCRNGGMCENIPGNYTCHCPPKDYQGIVYGGVDCREIFLGCTQDKCQNNGICIPYVQNGQHEFSCLCPSGYSGSLCDIMTTLSFEGNSFLWITSTPGPIKDSLSNIALSFQTVQPSALLLLRGDKDTHVKLELWNGYVSLSIQANNQSKVLLHISHNVSDGEWHSVEVTLAEAVTLTLRDDSCVEKCVNKTPSPIERDQVMIAFQNTFLGGLPVGKTNDGATLLNIYNMHSAPSFVGCLQDIEIDLNLITSENISSGSSFNVKAGCDRKYWCENHPCQNRGRCVNLWLSYQCDCYRPYEGLNCLREYTPGRFGQDDSTGYALFRLDNNPEEIVTLSMFVRTRRSFGFLLALRNSTFQYLSVWLEHGRLAVLAPSSPKLLGRSLLNDGNIHLISLKIIPNKIELYQSSQNLGSLSTSTWKIQTGDILYIGGLPDKKGTEVWGGYFKGCIQDIRLNSQKLEFFPITKGNSTLNQTLVNVTPGCTGDNLCKYNPCHNGGVCYSIWDDFTCSCPPNTAGKACEEVKWCELSPCPPEFQCQLVSKGFECIASAVFSGRESAIFFRSNGKITRELTNITFGFRTRDSDVILLYAEKEPEFITISIQNSRLIFQLQSGNSFYMLSLKSMQPVSDGMWHQVFLSMIEPLAQSSRWRMEVDDQTTIVTSAVATGNLNFLREETNIYLGDKPFDNLDGLRGCLSSIEIGGIYLSYFENADGHTKKPQDEQFLKISTNSVVTGCLQVDACNSDPCWHDGDCEDFYNSYGCVCPIGWTGAHCEINIDECFSKPCVYGNCSDRIAGYTCKCNPGYTGVNCETNIDDCENHRCANGATCIDGINGYSCLCFGNYTGKLCRQTRLPMTVCGNERRNLTCYNHSNCTELQGDLKCVCRPGFTGEWCEKDINECDSDPCLNGGLCQNLLNTFQCNCDGNFAGERCELDLTDNLISDIFTAIGSITLAVLLILFLAVVASFIASNKRANQGTYSPSRQEKEGSRVEMWNMVQPPPMERLI
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane; Mediates sugar transport across membranes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MALENFREILSVTATITTIIQFLTGVIICLSIRRKGGSGDISGFPFIAGVLGCSLWLRYGMLMKDTAMTVVNAVGLVLQLCYVFMYYLYATNKGPYLKQVVIVFSVILSTMLYVAVEPIEDKAEFRLGLLCCATTLIFCSAPLATLGDVLRTRSTETLPFYLILANVFVAAQWFLYGVAVHNTFVQVPNFISCLIALFQLALFAFFPSTNTRTKLQVSDEE
The following text describes a protein:
Function:
May contribute to the regulation of cell proliferation.
Subcellular Localization:
Cytoplasm. Nucleus. Mitochondrion.
Sequence:
MVLWIMSAGFCRVSSGLCRVSSGFFRVTSGSSRASSVFGKFRLVSAGSARFCSGCEERLCPPLLAGDVDRFGGVTVRDFPPDISEEEFSDLLKVSLHQWRSEGRVAVWLHVPISQSRVCSAAARHGFSFHHARGDQAVLSVWLAEGQNRLPAFATHQVGVAGAVLDESNGKVLVVQDRNKTKNAWKFPGGLSDLGENIADTAVREVFEETGVRSEFRSLLSLRQQHTHPGAFGMSDLYLICRLQPLSHRIHICTHECLRCDWLDLRELAETSETTPITSRIAKLLLYGLENGFQHIDLHMEELPAVYSGLFYQLYHRPMPDGGKQYSKGAI
The following text describes a protein:
Function:
Plays an important role in transactivating viral early genes as well as activating its own promoter, probably by altering the viral chromatin structure (By similarity). Expression of IE1 and IE2 proteins is critical for the establishment of lytic infection and reactivation from viral latency (By similarity). Disrupts PML-associated ND10 nuclear bodies by interfering with host PML and SP100 sumoylation thereby altering the regulation of type I and type II interferon-induced gene expression (By similarity). Promotes efficient viral growth by interacting with and directing host SP100 to degradation, leading to enhanced acetylation level of histones (By similarity). In addition, functions in counteracting the host innate antiviral response (By similarity). Inhibits the type I interferon pathway by directly interacting with and sequestrating host STAT2 (By similarity). Also targets type II interferon pathway by repressing IL6- and STAT3 target genes (By similarity). Repression of STAT3 genes is due to STAT3 nuclear accumulation and disruption of IL6-induced STAT3 phosphorylation by IE1 (By similarity). This repression is followed by phosphorylation and activation of STAT1 (By similarity). Inhibits host ISG transcription by sequestering host ISGF3 in a PML- and STAT2- binding dependent manner (By similarity). Alters host cell cycle progression, probably through its interaction with host E2F1 or RB1 that overcomes the RB1-mediated repression of E2F-responsive promoters (By similarity).
Subcellular Localization:
Host nucleus. Note=Colocalizes with host PML-associated nuclear bodies very early post infection.
Domain:
The N-terminal region is required for nuclear targeting. The C-terminal 16-amino acid is termed the chromosome-tethering domain (CTD) and is required for the association of IE1, host PML and host STAT2 with the mitotic chromosomes. Targets host nucleosomes by directly binding to the acidic pocket of core histones.
Sequence:
MESSAKRKMDPDNPDEGPSSKVPRPETPVTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLTELVKQIKVRVDMVRHRIKEHMLKKYTQTEEKFTGAFNMMGGCLQNALDILDKVHEPFEDMKCIGLTMQSMYENYIVPEDKREMWMACIKELHDVSKGAANKLGGALQAKARAKKDELRRKMMYMCYRNIEFFTKNSAFPKTTNGCSQAMAALQNLPQCSPDEIMSYAQKIFKILDEERDKVLTHIDHIFMDILTTCVETMCNEYKVTSDACMMTMYGGISLLSEFCRVLCCYVLEETSVMLAKRPLITKPEVISVMKRRIEEICMKVFAQYILGADPLRVCSPSVDDLRAIAEESDEEEAIVAYTLATAGASSSDSLVSPPESPVPATIPLSSVIVAENSDQEESEQSDEEQEEGAQEEREDTVSVKSEPVSEIEEVASEEEEDGAEEPTASGGKSTHPMVTRSKADQ
The following text describes a protein:
Function:
Mitochondrial proton-coupled zinc ion antiporter mediating the export of zinc from the mitochondria and involved in zinc homeostasis, zinc mobilization as well as mitochondrial morphology and health. In nucleus, functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt-responsive genes.
Subcellular Localization:
Endoplasmic reticulum. Mitochondrion membrane; Multi-pass membrane protein. Nucleus.
Sequence:
MFPGLAAAAAAHRCSWAALCRLGGGPAVARGRSQGWKNLMTFESFTSMIPSIHPQISVLNQVKLYSTNVQKGGQGSQTPRTDKAPPLTQAAENIGAELKAPLKQDPLQVRVKAVLKKREYGSKYTKNNFITGVRAINEFCLKSSDLEQLRKIRRRSPHDDTESFTVFLRSDVEAKALEVWGSLEALAREKKLRKEAEIEYRERLFRNQRILREYGDFLGNTKPRSRAISVFLKGPGKVVMVAICINGLNCFFKFLAWIYTGSASMFSEAIHSLSDTCNQGLLALGISKSVQTPDPSHPYGFSNMRYISSLISGVGIFMMGAGLSWYHGIMGLLHPQPMESLLWAYCILAGSLVSEGATLLVAINELRRSAQANGTSFYKYVMESRDPSTNVILLEDTAAVLGVMIAATCMGLTSITGNPLYDSLGSLGVGTLLGVVSAFLISTNIEALLGRSIQPEQVQRLTELLESDPSVRAIHDVKATDLGLGKVRFKAEVDFDGRVVTRSYLEKQDFDQMMQEIEEVKTPEQLEAFMLKHGENIIDTLGAEVDRLEKELKKRNPEVRHVDLEIL
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MSLADKRSKYQRSQTLSYIRINKSQQKQSQSSDSSVSLEKISKNTLLPQSPANRTETKTETPISTRSLTPRSQNEQQSLFSNENIKLPQKWINSSLNQSVKVRPKSLTRKISYNEFHHSSSILSCSKSSNGSINIFNRVKDKIVETVYHTQDMPHWAAIVQEKRQKAANEYEAKIVDTLSRERSNEISQKNCKLLISSTETNEPISQKDSSIITKREKARQGFRRRSISQDSYPQNLLLPKAGTLTAKQSNEGITCSFGDFQAILQEFNNYMRESKGASKSSSTASNFSKHEDQTHCVKTPSDNTPNVINESTITQKVKSSAEKNSKESTFLHEFSLARIAETDCTARNSFDAVEVEYDENGQTWGVYGAEIDPEILGNAIQLHLQRLIDQKLNINESEKKPIRPNRKYEMKQMSSEASCFVSKFFCFIKKKSCDVNITDE