lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Sequence:
MARYHIETYGCTSNRGESRDIERRLRDAGHHKVETAADADVAILNTCTVVEKTERNMLRRAKELADETADLIVTGCMALAQGEAFADADVDAQVLHWDDVPEAVTNGECPTTTPDAEPILDGVVGILPIARGCMSNCSYCITKQATGRVDSPPVEENVEKARALVHAGAKEIRITGQDTGVYGWDTGERKLPELLERIATEIEGEFRVRVGMANPGGVHGIREELAAVFAEHDEIYNFLHAPVQSGSDDVLADMRRQHEVSQYRDIVETFNDTLGEWTLSTDFIVGFPTEDDDDHEASMDLLRETRPEKINVTRFSKRPGTDAAELKGLGGQTKKDRSKAMTELKMDVVGEAHESMVGTRRDVLVVEEGTGDSVKCYDGAYRQVIVQNATDHGLEPGDFATVEVTSHQTVYAFAEPVDAAAVDDGPAETTAD
The following text describes a protein:
Function:
Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
IFHTLSIFHCSFTKCERVLSTLYRIVFCMNGIGNKCLFLPDAKERPARRFSAEGVFNYSSLLLSSEEDVLFVGGREALFALNLSDISNGKLHKNLTWSTPEKKRHECSFKGKNLQTDCFNYIKILLRLNSTHLYVCGTYAFSPICAYIRISDFSLVKSEKGDIVTEDGRSRCPFDPEYKSTAIMVDGELYAGTVSNFQGNEPIIYKSLGQGTPLKTENSLNWLQVDPAFVGSAYIQESLPRGNSVGDDDKIYFFFSEAGKEFDFFDNTIVSRIARVCKGDMGGERVLQKKWTTFLKAHLLCSLPDDGFPFNVIQDMFVLTPGRQHWKNTTFYGLFTSQWYRGASGSSAVCAFSMEQVERAFNGRYREVNRETQQWYTYNHPVPEPRPGACITNAARQMNIHSSLHMPDKVLNFVKDHFLMDSVIRSQPILLKRNVRYTQIAVHRVQAISRTYDVLFIGTDDGKLHKAINTDHRMYIIEEISLFAEPQPVQNIILDLEKGVLFVSSHSGLVEVPVANCSNYQSCGECILSRDPYCAWSGRHCRDVRQASPDRSWKQDVEEANTSAACSIALPGPRSFNPSGKSGFECQAFVLPANTFKVLSCKLHSNLAQRRWVYSDSASQFVYASPDGGLVVVAQADMPETYECWSVEEGFRQLVANYCVRAEKLPDTTTTTTASTARSRTPRVQVDGSLILPGESRSPQLSPKTYWNELLIVCALLGFSFLVFSLFVVYRNRDHMKSVLKQGECPNMQQKKPRMGGKPAESLPLNGSAVPASTSDHKGYQTLNDNYICSTPTHESPDHGKGFTESEKRPLDFKESHVEISPTCPRPRVRLGSEIKDSIV
The following text describes a protein:
Function:
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Sequence:
MAKRKGKGTRSESNRNLEELRRKAVEIVKRLEKVYLNPRLELEYENAFQLLVMAILAAQESDKVVNKVSKEFFKKYKTPQDIARANLEELEEDLKHINFYRRKAKLIKECCEKLIELYKGEVPKSVGELVKLPGVGRKTANMVIGGAYNLPAIIVDRHVHRVVERISLSKQKNPDKMEMELSEIVPQELWTKFSLLLLNHGKTICKARNPECEKCPILDLCEYGQKNLKGRK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation.
Subcellular Localization:
Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE
The following text describes a protein:
Function:
Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Sequence:
MAKALVTRFNPRQKQQENVTIEALALVPWSKRMGDPVPEVAALKTIAHLDSHYRLWCCLDNGAIEIVLPISGRHDNTIQIHSQLITAILYHDGYVWTAAYDGTIAVTNARTHKILDKLKFHSDAVSCVHKDDKGRIWFGSLNGQISCWDLVDPAGRNPEVVAVVNLEASEVRAALKENEQLRIYSLRYHQDKLWLAAGSTIVVYDLQLHRAILHLPHGIVPAPATPNTSSTTSHSAHAADLSSYTSYSQRASASTDLDSLAALSMADTMSVGSNMSMASTTTTKSMPAPEDDSIHPAALVASAIEQHHQQQQLHQHQQHFQPALPHQHRPPMTNRSRAGSNSSKLNAAAQRAIKLLSNSSSNDGRSGSDSRRGSMPALSSNRGTLSPTGSRNRPLSPNRLSPHPAGNGGPRERSNSLFRAREREQLGFPDAATASGPVAQANAFLRRMKSAREHQRQRSEAQPTVSSGRPPSGGSVSSLVLPNTSRPLAVERPRSGSTKAGFAPFSTAGVVSSDSGLNAEWKPIQAERFARSADTSPLKMPVRDSGVGESMPRPSAARPLLPDLSQATHPRLSTLTSASSNPPGAISALPSPHSVVSVFGEEEAPAAQESKPWAKDRLRKILGFHGGGAATLSPDELPRFYRRGANLDGEDCPTPPSSVSNKNLVYLGSSYSSFGSRRNGDTRHMTVAAHCLELGVNNDLWTGCENLGMVQVWSLTDGNMIWEVHADCGGIVVLRLITGRMWAACATGSLLVWDAVTYEPLQEIDAHADAARFLLPVSTDVLLSSGASQDGTIAWWQLLAPGQQLSLAHFSPFEEEPVDDGKSRHAFMAYNRYGFALDTFLRNEDGSWMLMLDDELPPSAQATITAREHRNSSWLQLLADHPNLEGVSEDSQLTTCVANGVPNQHRISVWSVLLNRWIGQERAARGGNYYNELCRRGKSPCDAQIMLDLPRTFPHNRFFQDRRRRGWRCLRRVLNSFALHNAEIGYCQGFNFIAAFLLLFLPEEVAFWGMVALIDHIMPVGYYVDPMISPRADQRVMVDLVQVHLPALGARLAELEVDLSLVTFQWFFVMFVDMCDTELTLRLWDLIFVHGHNVIFRVVLALLKLHEAQLLQMEDRQEVYMRLRRLGYDVSTHLDTIIELAMSLPLDDQLIVERFDAHVEAISQEEQDVLRQRKSKNAVNAAAPPLSPGLPGSTPAFPIAGSVPVSAGPNAAAQSVVVHGGASRDGQLEDGSHGDNDAQVALPVPFSYGGPAAADLIAMAMQARVQTTTMQRNRLHSETDTGHLTVLGDEQVTPDLANLDLPKSQPMSLHAAMDVGGAAPAGKVAVSPDWTPQAVRRHHLDSFDSWTDSDDQRSGHWSGDQRSGEPADSHVMFRAGVERSTTVVPTAFSPAAVPGRRDDHHSPVPDDLANLTPSGPDSHADDLEQLSL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
MAAHVYLPVGHLPPWTRLPEEKEEGMRAQQQEKEAEKEGGGGGKRRKVAADVTIDLDILDCPVCYQPLRPPIFQCTVGHTISSSCHNKLPEKCHFCSLPTVYNRCHMVEHLVESIKVACSNCNHGCTARISYYQKEDHEKGCPHAPCFCPETDCGFSGPTAVLLEHFSGKHKWHSPKVTYNKAFRIRIHVGSTVLVGEDGNLFLVNMTMESRGGVISVCSVQPHSTGSSFRCKLTLSCTEPSFSQSMEFLIRSTNLYDGFPKDCFQFLVPKVLLRGAGTSATAMVGVTVTPQ
The following text describes a protein:
Function:
During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, iron and copper toxicity, thermal stress and acid and base shocks. Also shows a weak catalase activity.
Subcellular Localization:
Cytoplasm, nucleoid.
Domain:
12 dinuclear ferroxidase centers are located at the interfaces between subunits related by 2-fold symmetry axes. The lysine-rich N-terminus is required for self-aggregation as well as for dps-driven DNA condensation.
Sequence:
MSTAKLVKSKATNLLYTRNDVSDSEKKATVELLNRQVIQFIDLSLITKQAHWNMRGANFIAVHEMLDGFRTALIDHLDTMAERAVQLGGVALGTTQVINSKTPLKSYPLDIHNVQDHLKELADRYAIVANDVRKAIGEAKDDDTADILTAASRDLDKFLWFIESNIE
The following text describes a protein:
Function:
Binds GTP and exhibits intrinsic GTPase activity.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MSSSLQSNRQSLNRKVAVMGYPHVGKSALVLRFTQNIFPERYESTIEDQHSKHIAAFHRDYHLRVTDTAGQQEYTVFPRSCSLDINGFILVYAIDDRKSFEMCSNIYEKIVRTYGDTSIPIVIVGNKTDLSTQRVVRAEEGEELARQWDAKFVEITARESNRVHEVFELLLREIEISRGNLSPTERPNGNSPKRNPFKDDGKPCSIS
The following text describes a protein:
Function:
Toxin component of a type II toxin-antitoxin (TA) system involved in plasmid partition. Acts by inhibiting DNA gyrase, converting supercoiled plasmid DNA into a singly cleaved linear form in an ATP-dependent fashion. To do so it probably interacts with one of the gyrase subunits. Gyrase inhibition is prevented by antitoxin ParD, and is reversed in vitro by incubation with ParD. In cells that have lost the plasmid filamentation and growth inhibition occur; this is suppressed when ParD is supplied in trans. The parDE operon alone is capable of stabilizing an RK2-derived minireplicon under defined growth conditions in several different Gram-negative bacteria. It does so by the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system.
Miscellaneous:
MISCELLANEOUS: Plasmid IncP-alpha RK2 is maintained at 5-8 copies per chromosome.
Sequence:
MTAYILTAEAEADLRGIIRYTRREWGAAQVRRYIAKLEQGIARLAAGEGPFKDMSELFPALRMARCEHHYVFCLPRAGEPALVVAILHERMDLMTRLADRLKG
The following text describes a protein:
Function:
Toxin with unique selectivity to KCa2 channels. Potently blocks human, rat and mouse KCa2.2/KCNN2/SK2 channels (IC(50)=27-140 pM), and moderately blocks human and rat KCa2.3/KCNN3/SK3 channels (IC(50)=0.6-4 nM), and human (IC(50)=0.7-12 nM) and mouse (IC(50)=28 nM) KCa2.1/KCNN1/SK1 channels. Does not show any antimicrobial activity. In vivo, intracerebroventricular injection into rats of a dose of 1 ng results in neurodegeneration specifically in the Purkinje cells of the cerebellum, and induces seizures characterized by hypersensitivity to noise, loss of postural control, paroxystic jerking, and alternating periods of great agitation with tonic-clonic convulsions and periods of total prostration. When administered at high doses, exerts anti-inflammatory, anti-oxidative, anti-fibrotic and anti-apoptotic properties in several models of inflammatory disease, including gouty arthritis, atherosclerosis, atopic dermatitis and acute kidney injury. Down-regulates pro-inflammatory signaling pathways, such as the NF-kappaB and STAT3 pathways, probably by blocking SK channels such as KCa2.2/KCNN2/SK2 and/or KCa2.3/KCNN3/SK3 which are thought to be involved in promoting some inflammatory responses. For example in mouse and rat microglia cells, inhibits LPS-activated KCa2.2/KCNN2/SK2 channels and TLR4 expression leading to the down-regulation of the NF-kappaB, STAT, and MAPK/ERK signaling pathways and, as a consequence, decreases secretion of pro-inflammatory cytokines.
Miscellaneous:
MISCELLANEOUS: Negative results: No activity has been detected against the following channels: KCa1.1/KCNMA1 and KCa3.1/KCNN4/IK/SK4, Kir3.1/3.2, 15 voltage-gated potassium channels (Kv), 10 voltage-gated sodium channels (Nav), TRPV1, three ASIC, three types of glutamate receptors, and three nicotinic acetylcholine receptors (nAChR).
Subcellular Localization:
Secreted.
Sequence:
MISMLRCIYLFLSVILITSYFVTPVMPCNCKAPETALCARRCQQHG
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MRTFMERVCVENRRPSPRRVWSPAATRCGESEAMHEDIHSLRRHGRLLVAVSPEAAMHLSKDKQLKSHPPKNVESEILREHIKKEREAAKAGKRPYYLKKYRACLSVFVQLVISEIDSSAATSLQVVKLLALYLTGDKEGAISSLKEWLSDSAIGSNPVLRLIAGIIFMHEQDYNEALKHTHSGGTLDLKNRYCKEAKACTSDPLKHPATVLQAQPPRKFTFRRGKVLNPEESSGSTPK
The following text describes a protein:
Function:
Promotes transcriptional elongation by Su(Tpl)/ELL. Essential for development (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MMMTKQKSTLTERLNIGGDEVRELKLGATFNPKNTSTAFHTIKYDFKPASVDTSRMATVDVGSNNQVTVTVPNLESSGVPQTVYKGNHKKYTKECLIIFDKETGAITLERLNHNIQVKKTRSEVTNKPSLMSATNAPMSNGAPVPSSAAAGTGSAGKLENSTMRISSKTKVSTGSRRNNIIDFKPRNSPMQQSSPSRPVASHRSPQSAPAWHANNAQQTLPSIPMIMDDDDFGLSAALHNGSQANISGSSTGSSAGQPDYASVHSGKQRQATPQGHAKRQQLTQRSSPPMQQQQHQNYGRGSNNYAQQQQQQQQQQLQQRASFSHSNHSNSMPMDMDSPTHNEQTAQSMAQAAAALEQQIGGELSASSSSSESDSSDSDSGSDSDDSTEDDRPNHHTNQQLPPAQQPQHHHMQHQQQQHMHQLPNLELGSVSPAYNSHHHHQQQQQSHHHHHHQQQQQQQHQQSGIYASNGGFPNDLLQNDLQLSSNSSDDDDD
The following text describes a protein:
Function:
Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MALEYGSTKRAMMTFTVGALFGGVVAMLVVSSEVLMDGVNKPLPDDGLRRQSYIRTLQETVGDLTPQAGRDQGQGYFDTIEFQAMNKGKEKSRVRVLCWVLTDPENHDSKALPAYDTWASKCDRTLFITTKSHSFLPTVVLNVTEGRESLLQKSIHAFKHVYEHHLDEADWFLKADDDTYVIMENLRHFLSNKNPEEPVYYGFRFNSIRPDTKNGYMSGGAGYVLSREAVRRLVTQGMDDPRKCRLHSKAPEDLEIGRCLEKAGVLAGDSRDEEGRQTFHCLSLQDHVLGNLPEWLHRYSTYPVKSGPDCCSKHTISFHYTEPIMMYVLDFAIHHIRPYGQCDRKD
The following text describes a protein:
Function:
Mannosyl transferase (ManT) required for the biosynthesis of mannose-carrying glycosylinositol phosphorylceramides (GIPCs). Maybe involved in cell-cell adhesion that maintains the integrity of organs by providing mechanical strength and facilitating the movement of metabolites throughout the plant during development. Prevents abscisic acid- (ABA-) mediated effects on development (e.g. cell size, flowering time, senescence). Probably implicated in beta-(1,4)-galactan biosynthesis thus being a cell-wall synthesis-related (CWSR) protein.
Miscellaneous:
MISCELLANEOUS: Initially thought to be involved in cell-cell adhesion , this function could not be confirmed.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MGGGEVSKEMGACSLAYRRGDQKLRKFVTARSTKFLLFCCIAFVLVTIVCRSSRPWVNSSIAVADRISGSRKGYTLLMNTWKRYDLLKKSVSHYASCSRLDSIHIVWSEPNPPSESLKEYLHNVLKKKTRDGHEVELRFDINKEDSLNNRFKEIKDLKTDAVFSIDDDIIFPCHTVDFAFNVWESAPDTMVGFVPRVHWPEKSNDKANYYTYSGWWSVWWSGTYSMVLSKAAFFHKKYLSLYTNSMPASIREFTTKNRNCEDIAMSFLIANATNAPAIWVKGKIYEIGSTGISSIGGHTEKRTHCVNRFVAEFGKMPLVYTSMKAVDSRNLWFW
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MSFKRRTPTNRQSPIDIRTSKVIPDPEKCSPLIIRFNPGDCVEVAVNEDGCWKVSARLHSTSVIRGSHLTGTYRLLQFHAHWGGSEHTVDGKRFDGEIHFVFWNTRYFSPEEACKKSDGLAVLGVFVEKGPANQEFNILLKAIEESNKTGKSVRIPPSFDPMRLVPRSGLSRYFTYLGGLTTPPYSECVVWTVMQTPITMSEAQLKTLGTLTDENWRECQRLHARKVYSTRGI
The following text describes a protein:
Function:
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subcellular Localization:
Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal.
Sequence:
MNLLNKSLEENGSFLTALYIIVGFLALYLLGRALQAFVQAADACCLFWYTWVVIPGAKGTAFVYKYTYGRKLNNPELEAVIVNEFPKNGWNNKNPANFQDAQRDKLYS
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
FGKDVPDENNNVAADELTDSLVPFYDGKNVLVTGGTGFLGKVLIEKLLRSCVGISTVYMLLRPKRGMTSEQRYREFVRHPVFERIRSKTPQLLAKLVCVGGDISLPLLGLSDQDRHTLVERVQVVFHVAATVRFNEALIEAAILNTIGTKQLLELCIGMRQLQSVVHVSTAYSNACRREVDEVVYPPPMDPDRFIQCVQLLPGEVIGAIAGQLQGAHPNTYTLTKAITEQLVAQYADRLPLCIVRPSIVTGAMAEPYPGWIDNVHGITGIMMEIGRGTISSIMCDERCTMDVIPVDVVCNTLIAAAWRQHYVRVTNRRSRWEFFFCNRFCFVFTTPVRVYNCTSGQVNGIKWHEYGRITQRCAVRNPTKHVLLYPGFQFRTNRLVHKLVELVLHFLPAYLFDALVRARGGQPIMTRLARRFQRAADTGEFFAMHEWIFRNGNLRRLGDRVRRDRAALSFRCDVAGLDWETYIEAYMFGIRRFVLLDEMDSLEQARAKLRRLLWFKRAVQLAGLLLLYYMCVLVFYSAVV
The following text describes a protein:
Function:
Acts as a transactivator along with IE2, and is required for oriLyt-dependent DNA replication in the transient transfection replication assay using native promoters.
Subcellular Localization:
Virion. Host cytoplasm. Host nucleus. Note=Isoform IRS1-263 is predominantly nuclear.
Sequence:
MAQRNGMSPRPPPLGRGRGAGGPSGVGSSPPSSCVPMGATSTAGTGASAAPTATPGHGVHRVEPRGPPGAPPSSGNNSNFWHGPERLLLSQIPVERQALTELEYQAMGAVWRAAFLANSTGRAMRKWSQRDAGTLLPLGRPYGFYARVTPRSQMNGVGATDLRQLSPRDAWIVLVATVVHEVDPAADPTVGDKAGHPEGLCAQDGLYLALGAGFRVFVYDLANNTLILAARDADEWFRHGAGEVVRLYRCNRLGVGTPRATLLPQPALRQTLLRAEEATALGRELRRRWAGTTVALQTPGRRLQPMVLLGAWQELAQYEPFASAPHPASLLTAVRRHLNQRLCCGWLALGAVLPARWLGCAAGPATGTTSPPAASGTETEAAGGDAPCAMAGAVGSAVTIPPQPYGGAGGSAICVPNADAHAVVGADATAAAAAAAAAPTVMVGPTAMAGPAASGTVPRAMLVVVLDELGAVFGYCPLDGHVYPLAAELSHFLRAGVLGALALGRESAPAAEAARRLLPELDREQWERPRWDALHLHPRAALWAREPHGQWEFMFREQRGDPIHDPVAFRLSDARTLGLDLTTVMTERQSQLPEKYIGFYQIRKPPWLMEQPPPPSRQTKPDAATMPPPLSAQASVSYALRYDDESWRPLSTVDDHKAWLDLDESHWVLGDSRPDDIKQRRLLKATQRRGAEIDRPMPVVPEECYDQRFTTEGHQVIPLCASEPEDDDEDPTYDELPSRPPQKHKPPDKPPRLCKTGPGPPPLPPKQRHGSTDGKVSAPRQSEHHKRQTRPPRPPPPKFGDRTAAHLSQNMRDMYLDMCTSSGHRPRPPAPPRPKKCQTHAPHHVHH
The following text describes a protein:
Function:
Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
MNLNGVNVWIPSNSGGTYLFQEASDILRLSNTGSRQHSCEKQDDDQVAWTNDRSRAPVNGFIGNRIKSFMWKKNLDMGKQMANNLADLTNQPSVDVVCKQDHVWKEILSREYQNLIQQEAYYPQAWQDEAEDFLSSNLTPISHTIDLGDPPLLCSSNLQSAQHDLSAASCMNYSMLQTGSSANKSPVSVSHVPEEIVDSPEPFSSVTVSSDVEWNANKEPYEDGLMYSDSSLLSISESISKSSIKPQYSDGVECNLGNYGGYLESNQNIYHENVPASHGQSLSHLNRWTSEPDIKSFSEDNTLPTAISYQLPNPRSHGCLVEQDASISNLSRQRSSLPNVFQLFPEQSPSIQQRDFHQLHNGSSNGSGFDEECNGYSSYINEATLPPSKRKRVENLPVLHFGPFNADASSGNQQSPIAGHLSLGQYSEGPTCSKRNKTNISNKIASCVKDLNIAGGSCNLPSIDMLRVDNGYYFSSTELSNDSELQKIEHTCTSGTENSEIDNSPKMSLDGSSFLPVEHSNDQREEIQQTSKYNQTTSATRSDLIEPKVNCQMGMRSSTEDSKRLSVSLTDFFTVEQLKNHIYSLSQYNQGSTGNMILHSVNENICQLCGTDRFVFVPVPIYCSSCCARIKRNLVYYWTVDKAGARHCFCTRCFRKSRGDNVSSRGLSISKQKFQKAKNSEQNEESWVQCDKCECWQHQICALYNAKKDLEGQAKYICPFCCLEEIQAGERVPLCAPLRATLGAQDLPRTMLSDHIEHRLFRRLKLESDERAKLSGQDADEVLGATDLIVRVVLSTNKKLKVKQQFLDLFHNENYPMEFQYKSKVILLFQNIEGADVCLFGMYVQEFGSECAPPNKRCVYISYLDSIKYFRPEKETVKGEALRTLVYHEILIGYLDYCKKQGFTTCYIWACPPVKSEDYILYCHPESQKIPKPDQLRRWYRSMLRKASEEDIVVNYTNLYDHFFVPSARNNARISAVHLPYFDGDYWSGAAEDLIRNIDKESRGDSPNKVKKLMTKRALKAIGHNNLSADATKDILVMQKLGQTILPVKEDFIIVNLHVVCTNCHEAILSGSRWFCYQCRNFHICARCLALKENFGEQKTHTSINGEKHLLSEVVVDDIPANTEDRDTIIDNDLFKNRHSFLSFCQQNHYQFDTLRRAKHSSMMILYHLHKKIHSSETDSGVGSDQFEGQKPLQVKLMGVLVHASQCRATPSNPCSYSGCLKIRKLFQHANRCKLRVPGGCELCLKTWSLLHWHSQTCQDFSCLVPRCMDIRKHVARNSSLQRGGKGLAST
The following text describes a protein:
Function:
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular Localization:
Nucleus.
Sequence:
MAENNNNNGDNMNNDNHQQPPSYSQLPPMASSNPQLRNYWIEQMETVSDFKNRQLPLARIKKIMKADPDVHMVSAEAPIIFAKACEMFIVDLTMRSWLKAEENKRHTLQKSDISNAVASSFTYDFLLDVVPKDESIATADPGFVAMPHPDGGGVPQYYYPPGVVMGTPMVGSGMYAPSQAWPAAAGDGEDDAEDNGGNGGGN
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGCCSNKQQVGVKDEAASQGVAPASSRKCRDVLCVLFFAVFWVGMIAIAAVGFMHGEPKRLLYGSDYNGSTCGTGEQEEYPLTFYPRITQDLLEQASNPSLSPEDFSFYGVCVESCPDAGSYICNYEAENEIQNDPSLTTDEERGRERKSRATSLLVLPSEKECWLVAMSSEQVFYRCLQLTESNSTSVEKCVVPGDEPEYYDEVNGVQVPNDKCEIKRVITTSEALGPAQENPLYSTLQTMGATIGRVIGDLQETWPVFLTCGGVLALVLGFAFVVLLRFCAGCIVWIMLWSFVLLLLLFALMLSAKGGIIGSSELSAITAELATAAAAAGVNATEMNVTTIELPQTLRASEDKQKAYAVAAYVSYVLAGVALLLVCFFQKKIRIAVGIVKEASRALQHLPLLVLFPIIPFIMLLVLFAYAAIVGAYIYSSGEMQLASLAGELADQAGQNVTAEATTTLSQVSPDQTMKLLVAYHFFGFLWTAQLINAISMCTIAGAVSRYYWSRNKTSEEMGPFPVLTSFKNCFRYHFGSLAFGAFIIAVVQFIRAALLYLDHQTQDVQKSNLVLKVVMKIVQCFLWCLEKCLRFLSKNAYILIAMKGHSFCSSAKDAFKILLSNIAQVGAVSTVTFLLLGAGKVAIALSCAIATFAYLEKNSDDYGVGGAHELSSPLAPILLALLLGWFVASTLLGVYEMAIDTILLCFCEDKEVNKTSGQYFMSDSLKKFVASVQVSKTESPATDIQE
The following text describes a protein:
Function:
Regulatory subunit of type 2A protein phosphatase. Not involved in HMGR regulation in seedlings grown in standard medium, but negatively regulates root growth in response to salt.
Sequence:
MEIDGGNDVQILDPELLQLPGLSPVSLKENPHIAEELFSQWLSLPETGRLVKSLIDDTKSSTPVSVSKNCTSLNVACGSALPSVFLNSGTPPLSPRGSPGSPRFSRQKTSPSLQSPLKSVREPKRQLIPQFYFQHGRPPAKELREQCISMVDQFFSNYIDGLHMDEFKSITKEVCKLPSFLSSVLFRKIDTSGTGIVTRDAFIKYWVDGHMLAMDVASQIYNILRQPGCKYLRQADFKPVLDELLTTHPGLEFLRNTPEFQERYAETVIYRIFYYINRSGTGCITLRELKRGNLITAMQQVDEEDDINKVIRYFSYEHFYVIYCRFWELDGDHDFLIDKENLIKYGNHALTYRIVDRIFSQVPRKFTSKVEGKMSYEDFAYFILAEEDKSSEPSLEYWFKCIDLDGDGVITPNEMQFFYEEQLHRMECITQEPVLFEDILCQIFDMIKPEKENCITLQDLKASKLSGNIFNILFNLNKFMAFETRDPFLIRQERENPTLTEWDRFAQREYVRLSMEEDVEEVSNGSADVWDEPLESPF
The following text describes a protein:
Function:
The B regulatory subunit may modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Sequence:
MNGGDEVVAAPAGPPHPLEWKFSQVFGERTAGEEVQEVDIISAIEFDKSGDHLATGDRGGRVVLFERTDTKDHGGSSRDLERVDYSIGRHPEFRYKTEFQSHEPEFDYLKSLEIEEKINKIRWCQIANGALFLLSTNDKTIKFWKVQEKKVKKISEMNVDPSKSMGNGSIASSSNSSSSRPYLANGGSPDRYNYISNDFSFPPGGIPSLRLPMVVSSHETSLVARCRRVYAHAHDYHINSISNNSDGETFISADDLRINLWNLEISNQSFNIVDVKPANMEDLTEVITSAEFHPTHCNTLAYSSSKGSIRLVDLRQSALCDSHAKLFEEQEAPGSRSFFTEIIASISDIKFGKDGRYILSRDYMTLKLWDINMDSGPVATFQVHEYLRPKLCDLYENDSIFDKFECCLSGDGLRLATGSYSNLFRVFGCAPGSAEATTLEASKNPMRRLVPTPSRPSRSLGNSITRVVRRGAETPGVDANGNSFDFTTKLLHLAWHPSENSIACAAANSLYMYYA
The following text describes a protein:
Function:
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Among the identified substrates are the SodA and Ino1 proteins.
Domain:
The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.
Sequence:
MAQEQTKRGGGGGEDDDLPGASAAGQERREKLTEETDDLLDEIDDVLEENAEDFVRAYVQKGGQ
The following text describes a protein:
Function:
Serine/threonine protein phosphatase that may dephosphorylate and activate lipins. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. Induces neuronal differentiation by antagonizing BMP signaling. Acts both by dephosphorylating BMPR1A and by promoting BMPR2 proteasomal degradation (By similarity).
Subcellular Localization:
Membrane; Single-pass membrane protein. Cytoplasm, perinuclear region.
Sequence:
MMRTPGLLGLRGFVAFAAKLWSFVLYLLRRQVRTIIQYQTVRYDVLPLSPASRNRLSQVKRKVLVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNNRGVLRRRFYRQHCTLELGSYIKDLSVVHSDLSSVVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQHRLW
The following text describes a protein:
Function:
Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAELYVKPGNTERGWNDPPQFSYGLQTQAGGPKRSPLTKRVAAPQDGSPRVPTSETSPGLPPMGPPPPSSKASRPPQFVGSCPPSRTEPMDSPVVESETLLEDVLRPLERALEDCRGHIKKQVCDDISRRLALLQEQWAGGKLSMPVKKRMALLVQELSSHQWDAADDIHRSLMVDHVTEVSQWMVGVKRLIAVKRSLFSEEEANEEKSIATAEQNQTVPGIQHDL