lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional activator that binds to the DNA specific sequence 5'-TGAGTCA-3' found in seed storage protein gene promoters. Involved in the endosperm-specific regulation of storage protein genes. Can activate the expression of genes encoding for the seed storage proteins glutelin, prolamin, globulin and the allergen RAG1. Functions synergistically with DOF3/RPBF to positively regulate quantitatively many seed storage protein genes. Functions synergistically with DOF3/RPBF to positively regulate some metabolic enzymes, such as alanine aminotransferase and pyruvate phosphate dikinase, that are expressed in developing seeds. Functions synergistically with DOF3/RPBF to positively regulate genes that are key players in the development of aleurone layers. Functions synergistically with DOF3/RPBF to positively regulate the glutelin GLUD-1 gene in endosperm of developing seeds. Can activate the expression of the bifunctional lysine-degrading enzyme, lysine ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH), one of the key regulators determining free lysine content in plants. Functions as a key regulator of starch synthesis in seeds, by direct binding to the promoters of starch-synthesizing genes, such as AGPL3, WAXXY and SBE1.
Subcellular Localization:
Nucleus.
Sequence:
MEHVFAVDEIPDPLWAPPPPVQPAAAAGVDDVGAVSGGGLLERCPSGWNLERFLEELDGVPAPAASPDGAAIYPSPMPAAAAEAAARWSRGYGDREAVGVMPMPAAALPAAPASAAMDPVEYNAMLKRKLDEDLATVAMWRASGAIHSESPLGNKTSLSIVGSILSSQKCIEGNGILVQTKLSPGPNGGSGPYVNQNTDAHAKQATSGSSREPSPSEDDDMEGDAEAMGNMILDEEDKVKKRKESNRESARRSRSRKAARLKDLEEQVSLLRVENSSLLRRLADANQKYSAAAIDNRVLMADIEALRAKVRMAEESVKMVTGARQLHQAIPDMQSPLNVNSDASVPIQNNNPMNYFSNANNAGVNSFMHQVSPAFQIVDSVEKIDPTDPVQLQQQQMASLQHLQNRACGGGASSNEYTAWGSSLMDANELVNMELQ
The following text describes a protein:
Function:
Substrate-recognition component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations. Required for the adaptation to osmotic or heat stress. Specific for substrates with an N-terminal Pro (Pro/N-degron).
Subcellular Localization:
Nucleus.
Sequence:
MPRSLDNFQNEDSSHPNEQGAWADSGSGFPNPNSNDVSNSQRNHHRHMFPLARIRSELSEQDSSISFTHDPLHIPLPNPSNNNDNIFHPQVHSSFHSRSASRQRRRSGLSRSNATRYSRRSLSDWLETIRENNYDEASIPSFFSPHTERLVGRVLRLNRYLQNSELLDRNSSTFGSNPNSVFSAQPTEPSVEPPTSSFPIQPPLPPSRSISISNPQSLSFPSSFDQSNYNFQAASTPQFNPLIEHLRRSNSPLNPSHDSAGASTFNTYFPNSTYQNILNSLDNNPAVLDLNGPPNQESSSSASSYGSRTQTPNARSCSLNIVFHKHKKVCTYYMIRHYAKRRLFITPTWWLRSGSVFRGLQFGGVQSISGLPPLTNPKERWIVDVSIHVVDYKRRALEGQLNAQARSSDPSSTISTAWTGEILDFSEKLNFATEKWSAPLEIDVCYWRKLAPFQNMDTNTFLETITNPKKLYKICQKYIFMRWKDMLILKDQTDTSESRITGFYFCCLCRENGYIQGYYYDPKHAFCSQPLNLFPEQPSLSPSYHFV
The following text describes a protein:
Function:
Required to direct the migration of Q neuroblasts along the anterior axis of the body during larval development. This is dependent on its asymmetric expression in Q neuroblasts.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAQIVRQSKFRHVFCKPVKHESCMSDIRVTEITWDSLFCDVNPKFIAFINRGAGGPFMVIPVNKIGRVDKDYPFVDAHKAPCLEVAWSPFNDNVIASCSEDTTCKVWVIPDRGLNRNLSEPAVELTGHQKRVNTIAWHPVANNVLLTAGGENVMFMWNVGTGEALLEISGHPDQIWSINFNFDGSQFVTTCKDKKIRILDSHTGEVVHEGMGHEGVKPQRAIFVKDGLILSTGFTKRSERLYALRAPEDLSTPIVEEELDTSNGVVFPFYDEDSGLVYLVGKGDCAIRYYEVNNDAPYVHYINTYTTNEPQRAVGFQSKRGMSSEENEINRIYKLTTKGVVDILQFFVPRKSDLFQHDLYPDTRSTIPALTAEEFMEGKNAAPNRQPVNAAAAAAAAKPKVQVAKKANILSTLAPTAAESVPTQSYSERPPSSQQPSPRPSASPRPRPVVDDDMGIVTMREAPPSRPASSRASRTEIPPKEESKVDPMKPKQAVQLKSRAARDEPGGGAQTAGQRRAAAELERIKRDQSRTADEDNTLAPPPSSSRASASPRGSVSAASDVGHVPQNMDELLEDLMKMKAVLRQHERRIRMLEEEIADRNMSNAYSF
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MPGADVGADEQQEPAAARAEEMPEPTPAPAAAPPLTIFYGGTVVVFEDFPAEKTAEVMRPAAGDDLPIARKASLPWFLAKRKDRLVERAPYARPSSPAKEPEKKTVKPASASASCSTK
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MNRQLVQMFRKQFFQVPKYFASNEQPIILRNEKSGYYVNPEDVARRMIKVISLHDDVKNPSGITLQSTWTDIGLSDMAYVEVMVEVEREFEIEFPDIDVECFRTVNDAVEYVARSFFAV
The following text describes a protein:
Function:
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MVLATALGLRFDGGVVLAADRRVSYNGFILSKSARKVFLINERVGVSTAGLPGDFQELVDVLKYNITMYELENEKAATPTNVAKLLSILLYQGRFSGIYYAELVVGGIDNSGPKIFVLDPAGGLMEENFSAVGSGAQIATGILERFFKEGMSEKEAVELAERAMREAISRDALSGDGIDLLIITSKGSRMEFIPVRTA
The following text describes a protein:
Function:
Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces.
Sequence:
MEQRLLACTWLGTGGILLILAGMCVSGPFQVRLVNGPDSCTGRLEVFYNSTWGTVCDDHWNLAGAHVVCRQLDCGMGLSAIGGARYGRGKDPIWLDNVQCTGMEAALSECRARPWGNHNCGHGEDVSVVCSGAPAPGEIQVRLINGSSSCSGRVEIFHNGSWGTVCDDGWNMAAAEVVCREMGCGSALSAPVGATFGQGAGQIWMDDVTCAGTEAALSLCQVSSWGSHNCGHREDAGVECSEPTQVRLVNGSSRCSGRIEVHHNQRWGTVCDDGWDLADAEVVCRQLGCGKAVSAPGKAMFGQGHDPVWLDEVNCMGTEGAITECNLKHWGDHNCKHDEDASVVCSDPTELRLVNGPNHCAGRVEVLHHEQWGTVCDNDWGMEHAKVVCRQLGCGTPIYAPGWARFGRGYDPIWLEKVICSGMESALSECTVQSWGQHSCHHGEDASVVCTDPMAVQLVNGPSRCAGRVEVLERHQWGTVCDDNWDIRDANVVCWQLGCGVAIAAPGLAHFGRGSGPIWLSEVNCTGTEDSLSKCRARPKGVTGCHHGEDASVVCSDPTEVRLVNGSNHCSGRVEVLHNQRWGTVCDDGWDLNDAEVVCQQLGCGTAIWAPSAARFGQGYEPIWLDDVNCTGSEAALSECRARPWGVSNCNHKEDAGVVCIGPTQLRLVNGSNRCSGRVEVLHNQQWGTVCDNGWDLNDAKVVCQQLGCGAAVSALGSAHFGQGSNPIWLEDVECTGMEGALSECRSRKGEMSKCSHGEDAGVVCSDPAALRLVNGSNFCAGRVEVLHKQLWGSVCDDSWDMKDAAVVCRQLGCGTVLSAPGRAWFGRGHNAIWLDDVNCTGTENNLLECLAKPWGEHNCNHGEDAGVVCSESENIPSLTEPQGPSSSTPNPSPGSDSHHLDPSTGSAELRLVNGLNRCSGRVEILYDHQWGTVCDDDWSFTNAKVVCRQLGCGEAVSAYSSAHFGQGSGPIWLDNVQCIGTETALSQCQARPLGFSNCDHGEDAGVVCAEGIITETPAQLRLVNGPSQCSGRVEVLHDHHWGTVCDDDWSLSEAMVVCRQLGCGAAVSAPGSAHFGQGSGHIWLDNVNCTGAETVLSECPSRPWGSNDCSHREDAGVVCSDTKTSEHRLVRLMNGSNNCIGRVEVFHDQKWGTVCDDTWDLQDAAVVCRELGCGMAMSAPGSAHFGQGSDPIWQDNVHCIGTESTLEECTLNNWGEHNCGHSEDAGVVCTGTNPLQLRVQDGPGPCAGRVEVLYNATWYGVCDSSWTMLEAKVVCKQLGCGPAESAPIGAQFSQGHDLTLLEGLNCRGTESLLLECQQRNTGPGLCRHGMAAGVVCTEMKDIMHSCSVLSGLLGVVAMLCGILLVMYLGVRCRRQAGRILDKSHVRKMENAGMS
The following text describes a protein:
Function:
Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.
Subcellular Localization:
Cytoplasm. Nucleus. Cell membrane. Note=Localizes at the plasma membrane in the presence of a CAR protein.
Domain:
Upon interaction with ABA, the 'latch' and 'gate' loops change in conformation leading to a tight dimerization and the creation a surface that enables the receptor to dock into and inhibit the PP2C active site.
Sequence:
MKTSQEQHVCGSTVVQTINAPLPLVWSILRRFDNPKTFKHFVKTCKLRSGDGGEGSVREVTVVSDLPASFSLERLDELDDESHVMVISIIGGDHRLVNYQSKTTVFVAAEEEKTVVVESYVVDVPEGNTEEETTLFADTIVGCNLRSLAKLSEKMMELT
The following text describes a protein:
Function:
Involved in the export of mRNA from the nucleus to the cytoplasm.
Subcellular Localization:
Nucleus.
Sequence:
MAPPTGPRAGTGRAPPRGPRATGGGGGIQKRRANPRTDRDGDVSMDAPAGGSGRGGLASGGRGRGSKDARGGRGAVNSRTASRVVQNLQNYVSGGPVGKTQSNMATLKIHGMSNSKATGNRDGGLRSLLTFLERKASKDKAVTIGKSIMDGDYVWITVRKDDAPEILRLNGFTYAGAPLTITETTERMPRPEDKISKAAEETKQKLTAVLAARYNPELKLLDLSSLGTDPILSSMGTFDSKDRAEKAFKVLVVIASQQYKTAAEKREGIQAISLASNGLNDVMQVFTLATSLPDIKRLDLSSNNLDSLSKISKWQHRFQYLEELHLTGNPITTQPDFVAELIKWFPSLQNINGQIVRSPQEVTEALKGMHPTPLPQFPSNLRDGEANVASIFVQVFFPMFDSDRARLAAEFYDDDSWFSIQAIANSGRNLPWKTYLKYSRNVHKLGEKNPATVQRLFTGGNLIADMWKALPSTRHPSMENPGAWLIDCHTFPNLADPTGHGFATGLLITVNGQFEESDTTENLYGKRTFTRTFILGPSKPSNPPPVHPYRVISDQLTLHDWTPAETPAGQAPVANQVPQVPVTNAVPPAEPVMLDDATKNQLIQEVMKRTGMTAEYSELCLSGTANWNFELALKSFEEQRANLPPTAFINAV
The following text describes a protein:
Function:
Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier.
Subcellular Localization:
Cytoplasm. Membrane. Nucleus.
Sequence:
EREIFISICNAWDDQRKSVDYKLILSIFVIQDPKLRELLDVGNIGRLEHRMVTVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGTGEPDTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKTPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGIYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPIWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSESRTTPAENGVNHTTSLAPKQPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKTAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNSQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQMELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPASWPLDPGKVNHKTPSSEEVEGENPGKEFDTPL
The following text describes a protein:
Function:
t-SNARE which may play a role in determining the specificity of membrane fusion, protein transport and vesicle trafficking within the Golgi/endosomal and plasma membrane/endosomal systems.
Subcellular Localization:
Endosome membrane; Single-pass type IV membrane protein.
Sequence:
MDVLKLGYELDQLSDLVEERTRLVSVLKLAPTSNDNVTLKRQLGSILELLQKCAPNDELISRYNTILDKIPDTAVDKELYRFQQQVARNTDEVSKESLKKVRFKNDDELTVMYKDDDEQDEESPLPSTHTPYKDEPLQSQLQSQSQPQPPQPMVSNQELFINQQQQLLEQDSHLGALSQSIGRTHDISLDLNNEIVSQNDSLLVDLENLIDNNGRNLNRASRSMHGFNNSRFKDNGNCVIILVLIVVLLLLLLVL
The following text describes a protein:
Function:
May act as a GTPase-activating protein for Rab family protein(s).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MWVRPEDVLLANALWATERANPYFVMQRRKGHGGGGLTSLLIGTLDNVLDSKVKLPAPFRILLQLANSDVSYVISSASSFKEIESDWEWLTKYLLETLSNIDSDDDIKDFVKAKIESLVANCEPDEDTSTIEQETSKFKSASNRFHRLFNMPEQDKLVNYYSCSYWKGRVPRQGWLYLSVNHLCFYSFLMGKEARLVIRWTDVTSLERTNSVLLPDGIKVTTRDGEFCFSLLLHPTETFGLMEQLANLAMRQLLSQEGFEQDKSLPILTKNQGKTMKKVPTLKRDLDARAQSEYYRNLFRLPVEEKLDGHCECTLWSPHNKAHVWGTLYCSPNFLCFNSKIRQLLSVVVPMREITLVEKVDTSALIPNALHITTRSKANFLFASLRDRDYLTHLISDFLAKTPEPKYMSAIIPNALQITTCTYFKRTTNYSQKKYPMLCTSLLGQRDIGGEWELAGREQKPKKKTEFQPPLTQVFSSTPTDQITAKETVKEHLWRLHLAEYGRGVCMYRTVKTHELILKGIPDNLRAEIWLIFSGAINEIETHPGYYVSLVEQCEGKSSLAFDEIERDLHRSLPEHPAFQSDVGIGALRRVLTAYAWRNPSIGYCQAMNIVASVLLLYCTEEQAFWLLVAVCERLLPDYYNTKVVGALVDQGVFEDLTRDHLPELYDHLKDLGILNMISLSWFLTLFLSVMPFVCAVNIIDCFFYDGAKVLFQIALACLDANRTKLLSIEDDGEAMTILGAYLDHVTNRDSSIPATTMSVNNRSLGIPSPGFSTSVDVSNLILESYQKFGFITAENIESMRNTQRLKVVQGLEDSMRRNAVRSIGAESSDFDQKELEQLYAVFKTGHIQARNRGFSEVKDSTSWQQQYIDLYGFEPLFVTLTNWGKCEIADTLARRAFKVIAGDDSDLITFKGLVWGLGTICKGDVQHRLRFMYRMHIAPAITDDLEDSDGIDTCSEVTEDEQGAGVGASEPTGIPKTQKDVLVPDEATVSSSLKSRESIDRMLRSDEGNRDAVELPRMTQEQFIHLWKTMYSLFRELPNEQQMYQAIATVGNILLKLGDFAHDRNLMTDNKSAEETAQSLDSSLSERLVECAPTPSESGASSQALGPGSTGLIDSLWSISFEQFLASMLTEPYLVHYFEEQVDVIERLKRLKTEGISSFSAANTTNE
The following text describes a protein:
Function:
Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MARAPRWMLGWLLLACCVPHTEPLAVMSVDMGSESMKIAIVKPGVPMEIVLNKESRRKTPVAVALKENERLFGDSALGMSIKTPKVAFRYFQDLLGKQIDNPQVALYQSRFPEHELVKDEKRQTVIFKLSQTLQYSPEEMLGMVLNYSRGLAEEFAEQPIKDAVITVPAYFNQAERRAVLHAARMADLKVLQLINDNTAVALNYGVSGGKTSMPLHSFSFQNIMFYDMGAGSTVCTIVTYQTVKTKDSGTQPQLQIQGIGFDRTLGGLEMELRLRDYLAKLFNDQHPSKDVRKNPRAMAKLLKEANRLKTVLSANADHMAQIEGLLDDIDFKAKVSRQEFEDLCSDLFQRVPGPVQQALSSAEMNLDGIDQVILVGGATRVPKVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFMVRDAAMFPIQVEFTREVEEDDKSKSLKHNKRILFQRMAPYPQRKVITFNRYTDDFEFYVNYGDLSFLNQDDLRIFGSLNLTTVRLKGVGESFKKHSDYESKGIKAHFNMDESGVLSLDRVESVFETLVEDKLEEESTLTKLGNTISSLFGGGGHTPEAGENLTDSVQEEEESLAEAAKEEQGVKQGQKSSAEDAGEEQGEEKQQSPHPDQAEAVPPKEESQKNEEGEKSEARDPKEDKETVNEEELSKSSGAGTAAKAEEEKKIKAPKKQKLVHEITMELDVNDVPDLLEDELKSSMKKLQDLTIRDLEKQEREKSANSLESFIFETQDKLYQEEYLFVSTEEEREEISKKLSEASNWMEEEGYAAATKELKDKLAELKKLCRNLFFRVEERRKWPERLAALESLLNHSNIFLKGARMIPESDQIFTEVELGTLEKAINETTVWKNETLAEQNKLSPAEKPVLLSKDIELKIAGLDREVQYLLDKAKFAKPKPKKEKNATKSDSGKNATGTSESENTIPPTEGKQEEKPEDISPAKEPPTTEKVVTDDEPGSDSSSKKEKKPEAGGESRKNDEL
The following text describes a protein:
Function:
Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation. Also functions as a membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1 (By similarity). This pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (By similarity). Mediates androgen-induced vascular endothelial cell proliferation through activation of an inhibitory G protein leading to the AKT1 and MAPK3/MAPK1 (Erk1/2) activation which in turn modulate inhibition (phosphorylation) of GSK3B and CCND1 transcription. Moreover, has dual functions as a membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane. Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Mitochondrion. Nucleus.
Sequence:
MDDFISISLLSLAMLVGCYVAGIIPLAVNFSEERLKLVTVLGAGLLCGTALAVIVPEGVHALYEDILEGKHHQASETHNVIASDKAAEKSVVHEHEHSHDHTQLHAYIGVSLVLGFVFMLLVDQIGNSHVHSTDDPEAARSSNSKITTTLGLVVHAAADGVALGAAASTSQTSVQLIVFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPVMSMVTYLGLSKSSKEALSEVNATGVAMLFSAGTFLYVATVHVLPEVGGIGHSHKPDATGGRGLSRLEVAALVLGCLIPLILSVGHQH
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of arginine residues in proteins.
Sequence:
MNENKKTPLLNDNMVLSSRIRLARNVDKAPFPNKIDNKNGRDIIYRIENEFYKEVGKDTFKTIYLWNLEKKEINSLLEKHIISFNLINNIDKAAIIIDSSEENSIMINEEDHIRIQSITKGFNLEKAFEKANQIDNMIEKNVNLAFDKDLGYLTSCPTNIGTGLRASVMIHLPALSMNNRISALLNAISQLGMTVRGIYGEGSKALGNIYQISNQITLGLDEVEIMNNLKAVIKQIINEENIAREKFIESYEYEIKDKIYRSLALLKSAILLDNLECLNYISNVKLGIEMSIIKDIDENIINQLIIDTQPANLNRIYDKEMTEKESKHYRAMLVKERLKKQKFKEGD
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDTASHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQTSECIKIQPTDIQPDIFSYLLHIMYTGKGPKQTVDHGRLEEGIRFLHADYLSHIATEMNQVFSPETVQSSNLYGIQISTTQKTTTKEGLEMKENPSNSNGNRNIAQGDHPQLQLSLAIGLDDGTPDQQISHTSSQAMDELQKPPVSIKQERCDPESVVSQSHPSPSSEVTGPTFTESGIKIHLCHYCGERFDSRGNLREHLHTHVSGSLPFGVPASILESNDLGEVHPIGESSEALECHRLNTFLVKENEQQPDHLNRGTMEPLQISQLSLISKDTEPVELNCNFSFSRKRKIGCTVCGHKFLRKSQLLEHMYIHKGMTGSFTLSSKILKAKRLHLQSGSGKALLTPFYRKNPKT
The following text describes a protein:
Function:
Essential for cell growth and peptidoglycan synthesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The extendend C-terminal region contains a kinase-like region, which encodes a catalytically inactive pseudokinase, and an extracellular region reminiscent of carbohydrate-binding proteins.
Sequence:
MRPSPGEVPTASQRQPELSDAALVSHSWAMAFATLISRITGFARIVLLAAILGAALASSFSVANQLPNLVAALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLATTLLLGATTLSVLAAPLLVRLMLGTNPQVNEPLTTAFAYLLLPQVLVYGLSSVFMAILNTRNVFGPPAWAPVVNNVVAIATLAVYLAVPGELSVDPVRMGNAKLLVLGIGTTAGVFAQTAVLLVAIRREHISLRPLWGIDQRLKRFGAMAAAMVLYVLISQLGLVVGNRIASTAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNAAADDTPAVLADLSLATRLTMITLIPTVAFMTVGGPAIGSALFAYGNFGDVDAGYLGAAIALSAFTLIPYALVLLQLRVFYAREQPWTPITIIVVITGVKILGSLLAPHITGDPQLVAAYLGLANGLGFLAGTIVGYYILRRALRPDGGQLIGVGEARTVLVTVAASLLAGLLAHVADRLLGLSELTAHAGSVGSLLRLSVLALIMLPILAAVTLCARVPEARAALDAVRARIRSRRLKTGPQTQNVLDQSSRPGPVTYPERRRLAPPRGKSVVHEPIRRRPPEQVARAGRAKGPEVIDRPSENASFGAASGAELPRPVADELQLDAPAGRDPGPVSRPHPSDLQNGDLPADAARGPIAFDALREPDRESSAPPDDVQLVPGARIANGRYRLLIFHGGVPPLQFWQALDTALDRQVALTFVDPQGVLPDDVLQETLSRTLRLSRIDKPGVARVLDVVHTRAGGLVVAEWIRGGSLQEVADTSPSPVGAIRAMQSLAAAADAAHRAGVALSIDHPSRVRVSIDGDVVLAYPATMPDANPQDDIRGIGASLYALLVNRWPLPEAGVRSGLAPAERDTAGQPIEPADIDRDIPFQISAVAARSVQGDGGIRSASTLLNLMQQATAVADRTEVLGPIDEAPVSAAPRTSAPNSETYTRRRRNLLIGIGAGAAVLMVALLVLASVLSRIFGDVSGGLNKDELGLNAPTASTSAASSAPPGSVVKPTKVTVFSPDGGADNPGEADLAIDGNPATSWKTDIYTDPVPFPSFKNGVGLMLQLPQATVVGTVAIDVASTGTKVEIRSASTPTPATLEDTAVLTSATALRPGHNTISVEAAAPTSNLLVWISTLGTTDGKSQADISEITIYAAS
The following text describes a protein:
Function:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Also has 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. Acts as a regulator of ribosome biogenesis following stress.
Subcellular Localization:
Nucleus. Nucleus, PML body. Nucleus, nucleolus. Cytoplasm. Note=Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein.
Sequence:
MERNSGPEAGPEAELEEGEPEVKKRKLMCVEFASVASCDAAVAQCYLAENDWEMERALNSYFEPAVEESASESRPESLSEPGSCVDLTKEETNDSISSKTSTSEDKSVQQEDGSVFSFITWNIDGLDMNNLLERARGVCSYLTLYSPDVIFLQEVIPPYYAYLKKKASSYKIITGREEGYFTAIMLKKSRVKFKSQEIIPFPNTQMMRNLLCVHVSVSGNELCLMTSHLESTRGHAKERMNQFKMVLEKMQEAPGSATVIFAGDTNLRDQEVTKCGGLPNNILDVWEFLGKPKHCQYTWDTQMNSNLGIAANCKLRFDRIFFRAAAEGGHIIPQSLDLLGLEKLDCGRFPSDHWGLLCTLDVIL
The following text describes a protein:
Function:
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD.
Miscellaneous:
MISCELLANEOUS: Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma; MISCELLANEOUS: [Isoform 6]: Generated by alternative initiation at Met-69.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, P-body. Cytoplasm, Stress granule. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.
Domain:
Domains KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. The contribution to RNA-binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules.
Sequence:
MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSGKVELHGKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVNTDTETAVVNVTYATREEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDLSIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSVLSPPAGPRGAPPAAPYHPFTTHSGYFSSLYPHHQFGPFPHHHSYPEQEIVNLFIPTQAVGAIIGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQEQKYPQGVASQRSK
The following text describes a protein:
Function:
Catalyzes the synthesis of activated sulfate.
Sequence:
MMQGLVLEWESVSVGVIRSPIDVSAMWGKGGRMLEAQSPGGGICGNDGRIKSSKVLQWKRRGRKGLCGGHCNAGALVRVNSYEQWPGRCVAAWSSGSARHDEVKQETMAEERDCRNGDASKAPLACTEDGSNGSISGLILPPLMTIGKSTNILWQGCMVKREDRQRMLNQKGCVIWITGLSGSGKSTLACTLDHALLQRGKLSYVLDGDNVRHGLNNNLGFSAEDRAENIRRVGEVAKLFADAGVICIASFISPYKRDRDACRKLMAPGDFIEVYMDVALDVCEQRDSKGLYKLARAGKIKGFTGVDDPYESPQEPEIVMKAVNGVYATPQEMTVQMLAYLEDNGFLTVGNRLRCSHFPICW
The following text describes a protein:
Function:
Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia.
Subcellular Localization:
Cell projection, cilium, flagellum.
Sequence:
MGFDYYIALDISRSAQDADIKKAYRRLALKNHWLNARDPGSAERFKQIAEAYDVLSDPIKKAIYDKFGEEGLKGGIPPEFSSQLTWTKGYVFHGDANKVFHEFFGGDNPYSDFYDAEGREVCLNFGGLRGRGIKKQDPPIERDLYLSLEDLFFGCTKKIKISRRVMNEDRFSSTIKDKILTIDVQPGWRQGTRITFEKEGDQGPNIIPADIIFIVKEKLHPRFRREDDNLFFVSSIPLGKALTCCTVEVRTLDDRLLNIPINDIVHPKYFKKVSGEGMPLASDPTKKGDLFILFDIQFPRHLTPPKKHLLKQALPM