lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Exhibits ATPase activity in vitro.
Subcellular Localization:
Mitochondrion.
Sequence:
MSKLTFLTSCEVASMRLRMILYHVKARELSGEADSILKIGKVRKDIKKPANPELVPVGYANQNVPKTVQRHLKWIMQKDNIQQDVFLIGNPGPLRRIIVMQYLELTKSELEYIRLSRDTTESDLKQRREIISGTAHYIDQCAVRAAIHGRVLVLDGIEKTERNVLPILNNLLENREMQLDDGRFLMAADRYDSLLKTHSKEELDARNLVRVSKEFRVIALGLPVPKYMGNPLDPPLRSRFQARDVEYLPYQEYLQSFQKEFRNIPKERLVKILSYGSTLLLSEDKLLGLPDFPLSNLYSVAKILDSAPEASTYQTLYKLYPYELILGYDGKMAAKHALQMFDVVDKVDARLPYRITDIKPSGNGSVASVTLQSHTKNLCHIEVPMGKNNPLRNVEDIKYFVPTSYHSGTLADMILSHMMRDFCLIGPKGCGKTLLVQSFADILGYHTENVVLYQDMTARDLLQQRVTLENGDTTWRNAPLITAALEGYIAILDGLHRLNPSTLMILQRLIDDRELTLHDGTRLMSVDKYKLLQESSGLSETELQERSILPIHPTFRIIGLAEPKGSSGKTSGQQWLNSELLTLFLHHEIRPLTKSEEIDVIKTLVPRVPEQDMGLLMKFTHSLRNNNDPTVQSISSSLSTRQLLRISRRLASYPNENLRHSIYKACLSKFLPPLASDVLENGLKEAEFVAEKLTDDADATYKVENDSLRIGKITTTRYKPDSEVMVPDVLFYDNLQHIKIMEDMLKDFLLGEHLLLIGNQGVGKNKIVDRFLHLLNRPRQYIQLHRDTTVQGLTLQPSVRDGQIIFEDSPLVNAVRNGHVLVVDEADKAPTHVTCILKALVESGEMLLADGRKIVTGVRQAEAPENAILAHKDFRLVVLANRPGFPFLGNDFFGSLGDIFSCHAIDNPPVDSEVAMLKKYGPDVPEEVIRKLVAAFGELRHLADDGQISYPYSTREVVNVVRHLQKYPNDGIANVVKNVFDFDNHQNELMEVVISTLRKHDIPIGASIRDIRLAKSFPLPPPTLMSNWTLSKQQRSFKPCSIETSYLIAQDRLEIGVDHFETQQIKQRSIAFNELLSTWQLFMHSSNRIAAVATTKDGKKNNIYAATCNPVSVYAMEEDADSYTFLDLYGMFPSTRYRWKPSLTISALGNSMNDCILLHEETSNTLMLVWPRKGEIQKIHTKSRFARVRDSFTRRMEESEELHKICNEFSHENWVVTYREHGSSKIHNINRKYLLKKEHETDLWPTILIQTEQEMLSSELQQEQDLQLSSKATSEAIVHKFLDISNIDNMTNRIVSDDMSYAGIAVGLPDNFLNDTDTAVGLFKVPRTLQPEKNSEIGRTVSDAVFLSSVGQVARIVKDVHVPEEISKEESSDHFIEVVDLQRHVVRFLPLPRVPRSNYVYTPGEIIPYAINALPDDRILVIDSTGRVTLWETGFSNLESSLDKWMQLVTDEGAAEDTQITIERPNDLEVTDPKHGKEDPSNAPHVGGNTWAGGTGGRSTAGLGGRGGPYRLDAGHDVYQVSDTDKEVVPPEISEAARKMNRKAFQDRLREIEMSEYDADAYDKVSNTVQRQVKALRVILDSLEAKGLERTWAKNQTTGDLDDNRLIEGLTGERTIYKRRADKEPEYNSQDQEHPKRLRLAVDVSGSMYRFNGVDGRLQRTLEATCMLMEAFENYDQKFQYEIFGHSGEDPEIPFIRYDKAPKNNKERLKVLKAMHAHSQFCFSGDTTMEATKNAVEKVVEDEADEHFVIILSDANLERYGLNAAKLGAMMSSDPRVNVFFIFIGSLGNQAERLKKKLPAGHAFVCMNTKDIPQILQQIFTSTMLLTR
The following text describes a protein:
Function:
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Subcellular Localization:
Nucleus.
Sequence:
MKQSKDPFEAAFEEEQESLPDSPVAPDELETQTPAATVVAFDAPDDDPGINIRSGQPSTSAAAQSTATTAGKTKEEEDEEEEENMDVELGKFPSSADPDKMAKMQAILSQFTEQQMSRYESFRRSGFQKANMKRLLASITGNPKISVPMTIVVSGIAKMFVGELVETGRMIMTERRETGPIRPCHIREAYRRLKLEGKVPKRSVPRLFR
The following text describes a protein:
Function:
Pleiotropic ABC efflux transporter involved in the protection of the cells against a wide range of toxic compounds.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGEKTAEAEAEKPSLLTRCTTFTRLLFYGSPSLKEALVLLTGLISAIASGIPFPIMAIVFGQLVDEMNSSTCNATPENADSYQSSINAKVLQIVYIGIAYFVLIYIYVFCWNISGEWLAQRLRERYFQSLLRQDAGFFDTLAPGEASSRITGDISTIQQGTSEKVGIVLNSIAFFVTSYVVAFIKDARLAGMLVSLAPAYLIMSLAGGYFVRKYFGRALECMAAASAVALEAFSNTMLVHAFSAGGRLEERFIEHLGPARVAGIRKSIATATQAGLLYFIAFSANALAFWQGSMKIAGAVEGGADGVTVGNTYTVILVLVDASLILSQVAPFLQSFDAAAVAFKKLEKDIERPSPIDGTADSGLVPAAAKIESDIEFRNVSFRFPSRPDKPILQDLTLRIPAGKQTALVGLSGSGKSTVAGLITRFYDAEEGQVTIGGHDVRELNVRFLRSAISLVQQEPCLLDRSILENIALGLVNSSAHVHLMDVLKSSALEDIATAIREKGLSLNHAIDLQPSNKDQIREIVSLVETAAGLADASNFINKLDHGYATMVGSSGNLISGGQKQRISIARALVKSPQILILDEATASLDSATELRVQRALEAAAAGRTLVTIAHRLSTIKKADNIIVMRQGKLIEQGSHAELLAADGAYAELVRLQNLNVNASQESASSSARPSLDSTALEKERNAEVTSVQDDESSTPSPKEKPADEEPVTTERSVGSTSKAIASLFRPYSLALLVAIIGAVVIGGTYCGSAVIFGNVVGKLSSCETAESIRHAGEFWGLMFFVLALIEFFANLISWSLFGWIAEQLIYKVRVLSLRSILEQKLEWHEARTPSGLLSLIVKDSNALNGLTGSVICTILSILVNLFAAIIMTHIIAWRIALVCLSVVPLLLGAGFMRVSTLARFEERHNDAFARSLGITVEAVTSIKTVHALAIESEVLSTYRRSLQGPMREITGQSAFTNLWLAVGYGLSNFVYALAYWWGAKQIIAGHYTQTQFFIVQLALLVSSQLWGQMFALAPDVSRAVQATRRLLNLLDLGSTKRLSDPILPPHSASTDIEATSHPSEKPPPPDPSGTQSGLSVSFKQVQFTYPARPDTQVLHGLDLTISAGQFAALVGPSGAGKSTIISLIERLYTPSSGTIELGNRNIAHMDASFRDEVAYVPQHSVLFDGSIRFNLELGARPNQALSQTEIEEACKLANIHDTIVSLPDGYDTAVGPNGDRLSGGQKQRLAIARALLRRPRLLLLDESTSALDAESERLLQDGLEKAARGITVIAIAHRLYTIRKADVIFLIEEGRCVERGSHTELMERSESYRVNALNQAVDG
The following text describes a protein:
Function:
May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.
Subcellular Localization:
Nucleus.
Sequence:
MRPGCDLLLRAAATVTAAIMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDDECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDESQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSESGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVAEWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLADENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQGLRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAKVSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSREWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTSRDASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPEGGDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGYGGIRPKQPFMLQHASGEHKDGHGK
The following text describes a protein:
Function:
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil. Probably interacts with both lipid and phospholipid moieties of lipid bodies. May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth (By similarity).
Subcellular Localization:
Lipid droplet. Membrane; Multi-pass membrane protein. Note=Surface of oil bodies. Oleosins exist at a monolayer lipid/water interface (By similarity).
Sequence:
MANVDRDRRVHVDRTDKRVHQPNYEDDVGFGGYGGYGAGSDYKSRGPSTNQILALIAGVPIGGTLLTLAGLTLAGSVIGLLVSIPLFLLFSPVIVPAALTIGLAVTGILASGLFGLTGLSSVSWVLNYLRGTSDTVPEQLDYAKRRMADAVGYAGMKGKEMGQYVQDKAHEARETEFMTETHEPGKARRGS
The following text describes a protein:
Function:
Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Moves along the ciliary axoneme and is involved in the assembly, localization and the movement of other intraflagellar transport (IFT) proteins along the cilia axoneme. May also associate with the BBSome complex in order to mediate ciliary transport. Regulates cilia biogenesis, morphology and sensitivity to environmental cues.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MSLKVIPCTLTKNQEVFKCVSAQLQYRRGEEEHGSGPIIHRWRPNGHTVAVACANNTVIYYDKKGNVIDALNPTGKLIDIAWDKEGDVLAIAVANTGTIYLWDVNSRNTDTVESGATSSKELPTCLAWSPSTPTLVIGNNAGNIVVYNHRTSRRIAVMGKHQRSVTQITVTPEDYVISCSDDNTLSVTTLEGTTVSTTTTNGEPTNMDYGSVNGKGGSGVTMVSVVIGKKILMLAHYNALDEPVNLQFQEKYGNIHSYRWFNDGYILIGFDRGYIISISAHNNEIGSELVSFLEYRGYLASIAVSTSFNKLLTIGDNMVKVRDLDELTTVTMLTEIETEKNLSEIEVTEDGQLVAVSSQSGVLSIFVTKMPTLAASYNNSICYLTNLTQVTVVAEVEKKGSSTLELNIEPTVMGLGPLNLAVANNNTVFFYDYHTPAQMQAAQQLQSTQSAAEKPTIVAAEPINRVEYLSTVTNIQLNYMYAAVNFGSRLRLHRIRNSEDNVSIEFPEANRNATLYSYALTENFLIFTTSNNYIVYFSLSEWAIVSEYRHVVPVRSIFPHPTNVVCCCFDDRLEAMIYSAVDDEVFRLPSVGSSAHYKGAIWETFTIDKNTFAVFDSQNIYVFLLSKQHIQGESVIYVSATRLPHAYVPLSLNKGIVTCLMSNGKLSSVLLDSHKTESVISDKSETVIDDILTRSLLMHRWSTAWKICIHSNDGSHWNQFAMAALLDSDVGMAIKIFREIGDAAMVTALELIETIEEKNLLHAQIYTILSRYDDAEQLYLESSRPMEALNMRRDLLEWPKALVLAETMNPKEIPYLSKEYAQELELTGDHANSLANYEKGVMENPQNLPELQEHNEICQSGIARMAIKTGDLRRGVQLAKQLEGRVVKRDCAIILEQMKQYTEAAQLYEVGLFYDRAAAVCLKANAWAKVGELLDHVKSPKIHIQYGKIMEKEKKYKVAVKCYETGRDYDNQVRLLLDPLNDPDEAVRVVRESRSIEGAKLVAKFFVKLGDYNSAIQFLVMSQCVQEAFELAEKNNAVREYAKAIEQHGNISQALELAEYYNRVNDMFMAAKFYTQAGQYNNAINLLFKNGDDENCVALAVDCGIKSKDKTLNNKLVKFLLGEDGNVKDPAQLFRLYVGLGRTKDAAQTAVVVAQIHQAKGNYRIARDLLFQMHQQLREKMMRIPLDMNKSLMAIHSYIIVKALINRKETLLAARLLIRTCGEIQRFPTHVVPILTSSVVICTQANLKKSAHKFAAQLMTPEYRPKIHEKYKKKIEDIVRKGGNQKDLVEENTPCPICDDLMPAYAMSCDNCKSLVPYCILTGRHIVASDFSRCPHCEMPGFYSEFRKLSILNENCYMCGGDLKGAIPEDAKAYLEKMEQDYK
The following text describes a protein:
Function:
May affect the expression of genes linked to host macrophage apoptosis and immune response, thereby promoting the survival of M.tuberculosis in host macrophages. Overexpression of the gene increases susceptibility of the bacteria to various stresses, but promotes intracellular survival in host macrophages. It has no impact on the growth rate in vitro. Overexpression causes changes in the transcriptome of THP-1 cells, including expression of genes involved in cell proliferation, fatty acid degradation, cytokine-cytokine receptor interaction and immune response pathways.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MTGPYFPQTIPFLPSYIPQDVDMTAVKAEVAALGVSAPPAATPGLLEVVQHARDEGIDLKIVLLDHNPPNDTPLRDIATVVGADYSDATVLVLSPNYVGSYSTQYPRVTLEAGEDHSKTGNPVQSAQNFVHELSTPEFPWSALTIVLLIGVLAAAVGARLMQLRGRRSATSTDAAPGAGDDLNQGV
The following text describes a protein:
Function:
Probable component of sperm glycocalyx. Likely protects and facilitates transport of sperm in the female reproductive tract. Probably released from the sperm surface during capacitation.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome. Secreted, extracellular space. Note=In the corpus epididymis, located in vesicles below the apical surface of the plasma membrane. Secreted by epididymal cells and absorbed to the surface of sperm during transit through the epididymis. Coats the entire surface of ejaculated sperm although presence on the equatorial segment is less intense.
Sequence:
MKSLLSTLVIIMFLAHLVTGGWYVKKCANTLGNCRKMCRDGEKQTEPATSKCPIGKLCCVLDFKISGHCGGGGQNSDNLVTAGGDEGSSAKASTAAMVGAAAMAGTPTKTSAPAKTSAPAKTSTTTKASNAAKASTTTKASNAAKASAATMAGNTTKVSTAAIASTPAQASTPTKANST
The following text describes a protein:
Function:
Protein involved in the regulation of cell wall assembly and 1,3-beta-glucan synthesis, possibly through the transcriptional regulation of cell wall glucan and chitin synthesis.
Miscellaneous:
MISCELLANEOUS: Present with 5680 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDLFKRKVKEWVYSLSTDDHYAEYNPDETPTFNMGKRLNSNNGQVNPSQMHLNSVDEEMSMGFQNGVPSNEDINIDEFTSTESNDGVSETLLAWRHIDFWTSEHNPDLNATLSDPCTQNDITHAEEDLEVSFPNPVKASFKIHDGQEDLESMTGTSGLFYGFQLMTLDQVVAMTQAWRNVAKNLNKRSQQGLSHVTSTGSSSSMERLNGNKFKLPNIPDQKSIPPNAVQPVYAHPAWIPLITDNAGNHIGVDLAPGPNGKYAQIITFGRDFDTKFVIAENWGEFLLSFANDLEAGNWYLVDDNDDYFSGDGELVFRDKKSNGPIQDYFEVLKRRTWIKYQENLRSQQQKSQPDTSLQEQKYVPASQKKVAAEQPSTLNAESIKGEDSGSADVQSVQDHESVKIVKTEPSEAETTTVNTESLGQAEHEIKADNVDIKQESERKEDEKQPKVEEKEHVENEHVTESAKKDDDVNKQTEEMNKKEENEIRSDDAKVEEAREEFENIAL
The following text describes a protein:
Function:
Probable methyltransferase.
Sequence:
MISYEYCDSSDSFYFNDIQDFDFNPWIEVKSVSEKGRCVFSKKFIPKGTMVFRDIPYAAIVDNQFKRNICTTCFKILLESNRHNFQTCPSCFQVNYCSNYCKQYSKIETKHTELECKWIQDFTVSFKHQMAEDDRNIVLLVLKILARRIHEKQSTIFHNKPLTTNTFETCTSNNNNIDLLPMIPNDIPDLIDHLDDYFINSKNNNEFENEEEEEEEQEQKGEGEQEENENNENNEKVKKKVIIIDDNEKEKEEIKKFNKIWKNDFKRLINIAKVIQIIIDDSIDSLENIKCDYGFVDNQGDTEMVDNSIDPKGLDKLVDNLSSSDLNILRLLCKIRANYFGLWNSAYKPIPLNSIDDDDDDNNNNKEKPNNDYLWCGSGVYLKLSLFNHSCFPNCTTLIEYNINKKNSNNNNGNNGNNNSYGDTNQLTISIITLRDIEENQELLITYIPLNQKINDRVKSLKSNWLFQCDCKRCHFEKINENQTEKIYKDSCCTNQKCSGGLLIPLEQNSTQGICRVCKNTYTLPTVFYPLK
The following text describes a protein:
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Sequence:
MATGRGRLLQLQWRGLQAPRLPLGVGSAPGRTGFRNGPCIRYAAGCATLKQHARRERHCERASADCSVSLDSMPSEILLKIFSYLDAGTLLCTGCVNRRFYHLANDNFIWIRIYSTAFSPKRSNWKVNSVEKTAVTMNLLSVEDKEAGYWKKEYIAKQIASVKAALAQVLKPVNPYTGLPVKTKEALRKSGLGWVIILKEKSGKEYMMEHVDLSVNDSSVTVVWYGKNWPLLATLSTLDLCGVTPVFMDRSKTPMKNGPRWHSLIAKYNLSNLTASTMFGCDRLIRIFCLNPGLLVGLWKREEELAFVMANLHFHHLVERSTLGSATIPYELPPHSPLLDDNPEYGLHGYQLHVDMHSGGIFYLCGTFRNLFTKKGYIENGYAKLIVISFKNNTEHLPLIGKVGLSWRTDIFDGCIKLIYLITSTNPYGVLPEWHVLCWLPEGWEKRSIQMSEVHRWTSDVVMKADDLSGAGEELQWGRPRWRGGCPLLGGWGASQRLCPVSRKRREKLYAKNRSRCL
The following text describes a protein:
Function:
Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MMAQSAEVLGTSQVGSFGNNVQCPVCSLEISAGQINSHLDSCLQGKAVGGVPGKKRRLSSNEESGKEVAQQPGKQFGPAGPTFPLFNKSKSFTGPSECATQSLCTSPSSRKQGVSVSSAEALHCQEDDDYRLPQHNLTPDAKKPNNLSEKLNGKPLADKMRPTDLNDYMGQKKVLGENTLLRNLLQSNDIPSIILWGPPGCGKTTLAHIIAKNTHKSSCRFVTLSATSASTSDVREVIKQAQNEQRLFKRKTILFVDEIHRFNKTQQDTFLPHVECGTITLIGATTENPSFQVNTALLSRCRVIVLEKLSVEAMEAILMRAVGSLGIKVLKVGEQPVHSSSDVSETPIYVEEKALTTLAHLCDGDARTGLNGLQLSVQASLAAEKDPIEHGIIIKEEHIKEGLQRSHILYDRAGEEHYNCISALHKSMRGSDQNASLYWLGRMLEGGENPLYVARRLVRFASEDVGLADPQALTQAVSTYQACHFIGMPECEVILAQCVMYLACAPKSISVYSAYNKVKECLKNHKGPLPSVPLHLRNAPTKLMKGLGYGKGYKYNPLFSEPVEQDYMPEEMKGVTFV
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
Subcellular Localization:
Nucleus.
Sequence:
MAKQQYRDDQTPKKISHIQFGLMDHYEMQRLSEVRVYSKEFYTGLPDRKPAPFGPLDRRLGAFDKSLDCATCSQNLRKCEGHFGHIELELPVFHVGFFKATLSCLQRICKSCSRVMLSHKQATVFLRRLQDPNLERGPRAAIIKEVGDQCRKNAASCPHCSACNGVVKRPKNSVLRIVHERFTKKNNRLREAHHQLFQEAASEVKDLSASLKADKVQDELNPLRALQLLRAVPDQDCPLLDMDPFCGRPEKLILTNLIVPPGGSGSNEDPLTTGLAAKRVEDAGGQKIERIMQTWEALQVHVALYFNGDLPGLPKDLKPKKAPRGFYQRLKGKQGRFRGNLSGKRVNYSGRTVISPDPNASIDEVCVPYHVCKILTYPEMVNDYNIQRLRAAVENGPDNYPGAVLLEKSRDKRTYDLAHCNRQKSARELAKGDIVRRHLIDGDYALFNRQPSLHRMSIMCHRVKARPWRTFRFNECVCKPYNADFDGDEMNLHVPQTEEAKAEAALLLRTTHNLCTPCNGEPLIAACQDFITGCFLISQKDTFFTKAKVMQMVCAFSDGSLKISLPVPAIVKPVAMWTGKQVFSMMMRPSKDDPHQVDLTEKNKSFDKNYEKSEVKKLGRDLTIGERSLCPEDGFVIIRSSRLLCGFLDKANVGESKSTIFYRLLRDYSAQAAVDGMLRMTKLTTRYLMERGFSIGLEDVTPPQELTDEKAVLIKTAFDKCSGYIAEYKSGRIECQPGQSAEETLESFIRKDLNQVREEAGSLCRKVLSPYNAPKIMAKCGSKGSPINMAQMIALVGQQILNGSRVPNGFEDRPLPHFRRFAKVPMAKGFVANSFYTGLTPAEFFFHTMSGREGLVDTAVKTAETGYMQRRLMKALEDLVVHYDTTVRNSSGHMIQFCYGDDGLDPQGMETDDCAVDLEHLFVHVLASDRDGPPPVTLQPAAVISTFESILKEQDLRDYDHPYCPLGLDVSADKEHFFLNQLRVFLEKRAQQLAEIRQRIGLAPALEAPAEDDPAKRHLVNNLMSVTREDMRIFVEKALFKFRRTVVEPGTAVGAIGAQSIGEPGTQMTLKTFHFAGVAAMNVTLGVPRIKEIINAAKNISTPVITAKLENDREESFARQVKARLETLTLGEVADHFDVVCNEDGGYVRVKLNLKVIQRKHLEVTMNTIIDSIAASRLTKIKHEHLSVMSSEVFQAVPVCDSKTVANRVHALRHLANVLPNCVITGLPGIRRAIIAKDPNEGTFSIAIDGTDLKGVMATPGVIGTTVDCNHVMELEQTLGIEAARSIIMDQVQYVMSNYGIHINPRHTMLMSDLMTFKGEVLGITRFGIAKMKESVFMLASFEKTTDHLFDAALRGTTDSVDGVSECIILGVPMRIGTGLFKLLHETKVEEQPKRRPLLFDQEQFHPSLPKRSQ
The following text describes a protein:
Function:
N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation. In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu. In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp. May act as a tumor suppressor.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MELILSTSPAELTLDPACQPKLPLDSTCQPEMTFNPGPTELTLDPEHQPEETPAPSLAELTLEPVHRRPELLDACADLINDQWPRSRTSRLHSLGQSSDAFPLCLMLLSPHPTLEAAPVVVGHARLSRVLNQPQSLLVETVVVARALRGRGFGRRLMEGLEVFARARGFRKLHLTTHDQVHFYTHLGYQLGEPVQGLVFTSRRLPATLLNAFPTAPSPRPPRKAPNLTAQAAPRGPKGPPLPPPPPLPECLTISPPVPSGPPSKSLLETQYQNVRGRPIFWMEKDI
The following text describes a protein:
Function:
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Subcellular Localization:
Secreted.
Sequence:
MRSSPGNMERIVICLMVIFLGTVAHKSSFQGQDRLLIRMRQLIDIVDQLKNYVNDLDPEFLPAPEDVKRHCEQSAFSCFQKVQLKSANAGDNEKKINVLIKQLKRKLPPTNAERRQKHRPTCPSCDSYEKKPLKEFLERLKSLIQKMIHQHLSRTHGI
The following text describes a protein:
Function:
Transcriptional regulator which has intrinsic repressor activity and which competes with the transcriptional activator IRF1 for binding to the 5'-[CA]GAA[AC]C[CT]-3' consensus sequence in gene promoters. May thereby play a role in keratinocyte differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MMRREDEEEEGTMMKAKGDLEMKEEEEISETGELVGPFVSAMPTPMPHNKGTRFSEAWEYFHLAPARAGHHPNQYATCRLCGRQVSRGPGVNVGTTALWKHLKSMHREELEKSGHGQAGQRQDPRPHGPQLPTGIEGNWGRLLEQVGTMALWASQREKEVLRRERAVEWRERAVEKRERALEEVERAILEMKWKVRAEKEACQREKELPAAVHPFHFV
The following text describes a protein:
Function:
Might be involved in the organization and polarity of the actin cytoskeleton.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MQNFWFAIFFFLLTCAPPSPLSYASTVTLSRRLLYDYESPLPLPLSPISPPFFPLESSPPSPPPPLPPTPPTTFAVFPTFPANISALVLPRSSKPHHTSPTLLLPALSAVLVIATVIGLALFLYGRHRGQTRHLKNSHCSSSNTSSYGDEQSHITTNFNMAATTSPSEVFYLNTEESDHIRTGGTFFLKQDSPEIRPLPPLPPRSFHHNNYETEVNEEDEEEEEDVFFSPMASLPGSANSSPSHSCSSSCSGWVSPARSFSITMSPPNPRYSDATNLQSPSPERLRVRKNYNGNGSSSLRMFSFWNQNMGFGFPRISSASTSPDRGFIRTPLSSLYSSVSTSPDGLFRKFLDSSPPIWNDFSRNVKSVLLSHTASSRRDFVINIGESSSQQSKVPALPPPTRPPPLVPPSQPFVVQNDVKKQSFSDQPPKQLHWERLRSSSSKLSKEMVETMFIANSSNPRDLPIQNQVLDPRKAQNIATLLQLLNLSTKDVCQALLDGDCDVLGAELLECLSRLAPSKEEERKLKSFSDGSEIGPAERFLKELLHVPFVFKRVDALLFVANFHSEIKRLRKSFSVVQVACEELRNSRMFSILLEAILKTGNMMSVRTNRCGDADAFKLDTLLKLVDVKGLDGRSSLLHFVVQEMMKSEGSVRALEGIRNLNTELSNVKKSADIEYGVLRSNVSRICQGLKNIEALLLLSEESGSYGDQWLKFKERMTRFLKTAAEEIVKIKIRESSTLSALEEVTEQFHGDASKEGHTMRIFMIVRDFLSVLDQVCKEMGD
The following text describes a protein:
Function:
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is involved in meiotic sporulation through regulating IME2 expression, and is also essential for 2-micron plasmid maintenance and for normal REP1 protein localization.
Miscellaneous:
MISCELLANEOUS: Present with 2330 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Note=Localizes to centromeric and flanking chromatin. Association with these loci is dependent on STH1.
Sequence:
MMPDDNSNSSTQNSSALYKDLRKEYESLFTLKEDSGLEISPIFNVLPPKKDYPDYYAVIKNPVSFNTLKKRIPHYTDAQQFMNDVVQIPWNAKTYNTRDSGIYKYALVLEKYLKDTIYPNLKEKYPQLVYPDLGPLPDEPGYEEFQQKLREKAEEVARANAARAESSSSMNSTEAARRLRKTRTSVKRESEPGTDTNNDEDYEATDMDIDNPKDADFPDLIRKPLININPYTRKPLRDNRSTTPSHSGTPQPLGPRHRQVSRTQVKRGRPPIIDLPYIQRMKNVMKVLKKEVLDSGIGLTDLFERLPDRHRDANYYIMIANPISLQDINKKVKTRRYKTFQEFQNDFNLMLTNFRISHRGDPESIKISNILEKTFTSLARFELSKPDRSFIPEGELRYPLDEVIVNNISYHVGDWALLRNQNDPQKPIVGQIFRLWKTPDGKQWLNACWYYRPEQTVHRVDRLFYKNEVMKTGQYRDHLVSNLVGKCYVIHFTRYQRGNPDMKLEGPLFVCEFRYNESDKIFNKIRTWKACLPEEIRDLDEATIPVNGRKFFKYPSPIRHLLPANATPHDRVPEPTMGSPDAPPLVGAVYMRPKMQRDDLGEYATSDDCPRYIIRPNDSPEEGQVDIETGTITTNTPTANALPKTGYSSSKLSSLRYNRSSMSLENQNAIGQQQIPLSRVGSPGAGGPLTVQGLKQHQLQRLQQQQHQYQQQKRSQASRYNIPTIIDDLTSQASRGNLGNIMIDAASSFVLPISITKNVDVLQRTDLHSQTKRSGREEMFPWKKTKGEILWFRGPSVIVNERIINSGDPHLSLPLNRWFTTNKKRKLEYEEVEETMEDVTGKDKDDDGLEPDVENEKESLPGPFVLGLRPSAKFTAHRLSMLRPPSSSS
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLGHSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWALLVKMCLFFGSAFSVPFLVVRHQLLKQ
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MASLFIIMDKRFAVFASSDKPNNCSRKNMFFLKNIIVLSNYLYLLYKAWIVCTTISLCCDFPLFNFLFIAIPYFTEILYNDSSLLWFLFVSLCFITLSFQSLEI
The following text describes a protein:
Function:
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
Subcellular Localization:
Nucleus.
Sequence:
MARILSNEDFVVVSVGRDVVIYHFGLEHIVHIKLKSENVQIDNNARNNENKNKKNDSITNKSTTESSKITSMACSHSKKYLSVSDDGKNLYVYDASNNWKLVNHRSIPKRCTSMKFTRDDKNILIADKSGDVLKFDVLGVEGLTSLESKDGKGVGGLVISGPKNAVSGSNDTDDNRDDDDSFVVAGHVSMLLDIELCDADRYLVSCDRDEKIRISNYPNCYNVHQFCLAHTDFVSKVLYIEECDLLLSGSGDGRIILWDYKSGRLLDSVNTFEYLGHDQSAICPSSFPNQSEEENVCRGVDVRNICYHKLTKFVFVIFERRRVVLTLKLCFPSIANENPTKSKMLQFVSVTNVNNNIQDISLLDEQLILLLAQESVAEGQICLSTFKIFEYALQLNELEPVYVDCLNKELQHMHVSSCQSSSDNSSGSGSCNRFECNLHKMRIDNISEYVERKNKRLMKRQDESGRKTKMMIMENEDEHR