lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNNEPLRPDPDRLLEQTAAPHRGKLKVFFGACAGVGKTWAMLAEAQRLRAQGLDIVVGVVETHGRKDTAAMLEGLAVLPLKRQAYRGRHISEFDLDAALARRPALILMDELAHSNAPGSRHPKRWQDIEELLEAGIDVFTTVNVQHLESLNDVVSGVTGIQVRETVPDPFFDAADDVVLVDLPPDDLRQRLKEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRVDEQMRAWRGHPGEEKVWHTRDAILLCIGHNTGSEKLVRAAARLASRLGSVWHAVYVETPALHRLPEKKRRAILSALRLAQELGAETATLSDPAEEKAVVRYAREHNLGKIILGRPASRRWWRRETFADRLARIAPDLDQVLVALDEPPARTINNAPDNRSFKDKWRVQIQGCVVAAALCAVITLIAMQWLMAFDAANLVMLYLLGVVVVALFYGRWPSVVATVINVVSFDLFFIAPRGTLAVSDVQYLLTFAVMLTVGLVIGNLTAGVRYQARVARYREQRTRHLYEMSKALAVGRSPQDIAATSEQFIASTFHARSQVLLPDDNGKLQPLTHPQGMTPWDDAIAQWSFDKGLPAGAGTDTLPGVPYQILPLKSGEKTYGLVVVEPGNLRQLMIPEQQRLLETFTLLVANALERLTLTASEEQARMASEREQIRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGSPHARQASEIRQHVLNTTRLVNNLLDMARIQSGGFNLKKEWLTLEEVVGSALQMLEPGLSSPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGENLQLDVWDNGPGLPPGQEQTIFDKFARGNKESAVPGVGLGLAICRAIVDVHGGTITAFNRPEGGACFRVTLPQQTAPELEEFHEDM
The following text describes a protein:
Function:
Has a cytoskeleton-independent function in chemotactic signaling during development.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Associated with microtubules and actin.
Sequence:
MTSTSGKPKMEKFGLQTDKSARVILFRNGDRYHVEGVHCLVHSSKFKTFDQLKLEFSKKVGLFTGNVQKVYSMDKKRIQDIKDFVDGHHYICCGAEPLNTEVIPKGIQDIFGKAEVSDQDDEPKPSKPFVSSVPPPPTPTPTSSSGTTTTSQPTLSASPSVSSAQSPKKPVVSAYKESAVHSIDKFSVQTEKAKVIMCFRNGDRYHSGERVTVHSTKFKTYDQLKEQLSKQVKLPTGPVRKLYLASSGKLVKTMEEIIDGEYYVCAGGETLNPLDFSPTLSEHVKQKKLQEQQQQASEQQKPQEQEIF
The following text describes a protein:
Function:
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
Sequence:
MTMSDEATAVAEYSAEAKELGDKIANMTLKQAKELSDYLKDEHGIEPAAGGGAVMMAGPAGDGGGAAEVEQTEFDVVLTGFGEKKLNVVKVVKNITGASLMDAKKMVEGCPATLKEAVSKEDAEKVKAEIEEAGGSVELK
The following text describes a protein:
Function:
Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May result from the retention of an intron in the cDNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFNIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCALCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGEFIFLRLNVLREYLERELTMASLPFPFDVERSIDDWVFMCFFVGNDFLPHLPSLEIREGAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGCQVASNPRQAAYEMRMQRNSSPSISPNTSFASDGSPSPLGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMSSEFEKGTKPFKPLEQLMGVFPAASGNFLPPTWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEENRRNSLGGDVLFVGKLHPLRDFILELYQTGSTEPVDVPPELCHGIQGTFSLDEEAILPDQTVCSPVPMLRDLTQNTAVSINFKDPQFAEDYVFKAAMLPGARKPATVLKPGDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVTPRGSGTSVYTNTALPPANYQGNNYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQHRFERSVGAEPLLPWNRMIQNQNAAFQPNQYQMLGGPGGYPPRRDDHRGGRQGYPREGRKYPLPPPSGRYSWN
The following text describes a protein:
Function:
Required for the export of polyadenylated mRNAs from the nucleus. Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage.
Sequence:
MVPSISFRSSRAQGMPRRTVTYAEEVSVGASVTSENQSEGKMAEKEQLRRQIRLLQGLINDHKNIHGNAPVPPPSLRWRNPRPAFTNQGSFSTRYSQQTQRDFPPCQTTANAWRNKYSLVNVPPRPTPPSSSSVSARTLRTTLNHGSSEEAGPQQVLSETNEGATMDRTVARVQAALAASSIAAPKSQWDTSAALGVPSAFQGHVSSSASTSNAGSKKSKELPYLLDFKTVPRSRDNDAPKVHQKIPMTAEAFQGASKFAPSLCRTIGESAIALKSEPQQSLTTHDHESSYLPKRKTPALQAPLLHSSQQPPGAKGKANPFNVADTSVVCTKSACKASSTPGKNLSERKHSAPTVQKTPVLPTSIKSPRFRKANYTWVANSSKSPRTVKRWATSRGSENAHKFSVSSRAAAKLQPRGELGVKQKKPGLHSKLGVSSSQYKWKASSLQSSPSTSTSLFTWHHKRHDGAGVSPNVDASPFLQPARRMPLGHGAPRPSCGNMGFYKLKSRTKIIKKKGNACSPVDKRNAAFSTVVLKSRYSLRKKSSPRGKSSPTARRAGTKGLVQIGKHRLRRLPASRAHASAREGSSYLLLPGSTANKVVNTRYRIVKKTTASPSSSTASFSSSAHSWRTRKLSASRSPLLGTTRHSPSGSKSQALQQQRWKNRNLRCIGGVMYKVSANKLAKVSSPPARSGETFSRSLIRTGRPDSANSPFGYPSPSFTSRSTPSRYIASRAVQRSLAIIRQAKQKKEKKKEYCMYYNRFGKCNRGENCPYIHDPEKIAVCTRFLRGTCKKTDGSCPFSHKVSKDKMPVCSYFLKGICNNSDCPYSHVYVSRKAEVCPDFLKGYCPLGEKCKKKHTLVCPDFSKHGVCPKGSHCKLQHLQRKHTAGPSSTKATFQRGSSEPKRGRPAAKTSRFYIKEKGEEEDVDDDEEIAGPSRSAQEAWQPRCLSHTSKLAKLPSFISLRSPPTSPEEEEDQKPEKDKHAEETGIHGAGFLWGKKDIFLPFGGSPFPGRHRERG
The following text describes a protein:
Function:
Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MAYPRTVEDVIKDFKGRRGGMIKALTKEFEEFYRLCDPNSPNLCLYGHPNQKWEVNIPSFSDLPEPRLGINFVRNTMTKHEWISMVALHSDAWLYSIASYFATKFNFDKADKKRLFNKLTEVSSLHEVVVTAGKKRVKTEGGGLPEEILVEEILSRLPARDLLKFRTVSSTWRSLIDDSDFVSTHMETYKNNIEVSHLLVMYRPARSWLKDEHVLVRRSDTFRKVMELQSLYDHYEGAYELISYINGLVLVKKGKSRGFREIILWNPSINSSINVPNPMFEAMREATYLELGLGYDASKKDYKVVVMVYPKAEIKYYFGERYRATGPGFVQVYTLSTNSWTSNNNVSPPPYWSVGGQVFVNGAIHWINFGPKLEDDLWYKDKDMYIVSFDVENEVFKYFELPKGLKTDDEPKEKFPTMLGGSLAVYCSHYQSRNDIWVMGEYGVSNSWSKRYTFSLQFDKLLHFKSNGELLFAVDGKGIKSYDVKKERVRDLAKTYARSSNYTVFTYVESLVLFKQASKRPLQLLV
The following text describes a protein:
Function:
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNRCSLWQQRARLDTVEPVKQAFPADVPPAAHSPAGAPDGHGTVFSHHDGEEHNDSANRDEQASYPSQSPLPPSPSAATPYTGNWPPYALLLVSCLIVAAAGLGGSAARVALQKCFEKNPFFPKYTYIGPNSLGSFLMGFSVTVLPPEGALPLTHRALCVGFCGSFTTFSSWIVKAMVQNTVADALEHLFIGGTMPLVFFLWGRDCGRGVRWCCEHVVDSPWETWPLHRSLLRAVDAVMFVLVFLASILAPVLVLVYIGEGGIRVISTDDVRMVVLAPAGAVTRFMLSVYLNKKACAAQFPLGTLAANLLGVLLAIIMYNMEVNHLSCEWCIAVQNGICGALSTVSSVANELVSFYGSGRMLSAYVYALVSVGFSVFIAGVGRPQLYRHAVS
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLSRHTVRSEYALGGRDLYRGADQHDPEAVLDGAAMAGLVGVLRQLGDLAEFAAQVFHGLYDEVMSTSARGHGLMLRVQQLEAELPLLEEDSCQRNYLHVVASNRGVDWHPNPRVDHGVVAGGDTPRFIMESVKQCRGPPKLFVLDKYDVGGDGACLKRYTDPSSFRTGSACPTTLLQEGTRDDRRPLRAVEISPNLQNAEIFRSPNAADNFSKLETGSSAGALDEVPTNRRRLKFRQLNGSVFQSFRPLMQNLHEKPSSEERLITGDHSKVHVFMVESPEPGAEERDVMVDTSDNMEKGKLTVRRKRSVSEEALSRSSDARSAGSSRGGYDSELDIYVDALTTMDSEDFSAPESGAREQATEEEEEEQRCNGSVTSAVSNGTRDITKKTKEVKENSKKIASKRSKYVGSMELTASKVGILPRELSEKHAPFSGSLRYMAKQLLELRYDGTQDSELYDVEADGVGRDVKYQEISDHAVEAKESDAVHKILSGSPYDDAGLGKCPQEEINHGQEHDVPPTDSPHDSAPDEGNGFQDSNMAYLVGIITSSSSQEGEGCTSTALHENSSMAVLNHVLEHAQERFGEDLDKEVDVDIHTEAISENTSDKCEDLKEVSIYTEQVNVEDMEEINESDVYALDDERAEYIEQQVVSDGSISSPVSSKQSDDPCWITPLTLADEDDTVACKVVDRPEGDHVILSETFKGIDLPNVVTESVINSKHDMPNNGQYYLHPKATFGQDLCLGSYKIVGENGEVPLCSSTTATTTPELTVNTETKHEFHQAVYQEPSNSFNSSAEVFGDPLAPDSRDDAPSVISSFDWMLNGATQKSFNIFPSHPTNGNAEENGSSEDVPPLPPLPPMQWRTNKIQTGPSPLSAKIGRPPRPKPSVKQQQSEASHVLQENSLHKGLSLQNELVQANISSDHEKNQILNIDFRESHHQEGEEYDAQDSNPFASSEVECLAEVASVKSENLHPLQLPELIVVLEEAWSEFGNIKFMPEQEGKFQLSNGLSVWNDLCTSGLSSQKTSEKPEFFADYKGKEFSFAGSDEVADSEENKPNGAVKHLQNPDLPAQQKDDIHDCDGKVTKFSSALEEDSSQSPTHTVSGPPRYPLLPVTSHDRSMIRKAPTLVQPSSMLADEKNTLLEQIKNKSFNLKPVLAKRPDVMGGPKTNLQVVAILERAHAIRQAVADDDDDDNWSE
The following text describes a protein:
Function:
Has a role in the formation of the multivesicular body (MVB). Required for the sorting of lipids to form intralumenal vesicles and for fluid-phase transport to the vacuole. Required for sorting the plasma membrane proteins STE2 and STE3 into the MVB. Acts a cofactor of VSP4, promotes the oligomerization of VPS4 and stimulates its ATPase activity by 6- to 8-fold.
Miscellaneous:
MISCELLANEOUS: Present with 4400 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein.
Sequence:
MASNAARVVATAKDFDKVGLGIIGYYLQLYAVELILSEEDRSQEMTALATELLDTIEAFKKEIGGESEAEDSDKSLHVMNTLIHDQEKAKIYMLNFTMSLYNEKLKQLKDGPWDVMLKRSLWCCIDLFSCILHLWKENISETSTNSLQKRIKYCKIYLSKLAKGEIGSSDEKTLDYADFADDSEEIKDEDVDHQTSDLENNNNDKVEGLAPKDQTTSYEPVDEVPEFIDDADSVNEEEQTVDKNEDAITKDEQQVVKKEVDLTRPSAPSEPAAAEHKSYTKDELTKIMDRASKIEQIQKLAKYAISALNYEDLPTAKDELTKALDLLNSI
The following text describes a protein:
Function:
Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.
Sequence:
MAAIPPPTATWDTIQDVFYRKDEIYSMGWKVSDLSDYIVTSARNSGPIAMIRDERKIMLLGKHPPGKPKIYVYTSSGILLNTFTWDLTPPILLHFTSQNLIVLSDEGLYRVYDLSNSGEYKQHTLGSDVAEMGLVDAQAWEDGMIVLTGELEYLQVSGWSGGRVIRLSPSGLGELPMSWSLLSPDKSPTGHAQVLFSTSSTIITLDALERIDQRVSRGPFSHIRVSPNGRFLALITVFGSLWVVSSDFSRNLSEVDIGELSDSAGLPEKVEWCGDNAVVLGWGGKVVVVGPAGDSLKYYYSPSAHLIGELDGLRVISATSCDFIQKVPDSSLAVFRPGSTHPASILYDALDNFERKSPKADESIRSIRPELADAVDTCIQAAGREIEVTWQRKLLKAAQFGRAFMDLYNPSEFVEMAQTLKVLNAVRYFEVGIPITYDQYITSSPSYLISHLISRNLHLFALRISQHLSLRPDPVLKHWATAKITRSNKGVDPSDRGVADDEQVCEAIVEKFEKEGERGVSYAEIAKKAWEAGRTRLATMLLDHEPQAAEQVPLLLQMKQDKIALTKAIDSGDTDLVYQVLLHLRSTLTPGDFFHVLDDSISPNLKPAVNLLQVYARQADRQLLRNFYYQDDRRTESACLEMEEAGQSQDVNDRIEHLKVAAKRFGESKERVFEAKMVEDAQRLLILQEAYERELAHKFKFTGLSVDEFIHKLLIEGFGKRAERVRADWKVPDRRWWWVKLKALAEVKDWDGLEAFAKSKKSPIGYEPFVTHLLSLKPSQPKHAATFVSRCDAKSRADLYVRCGEWGKAAEVARERGDRAKLEQLRRMAPNGFAQRDVDEVIQRSGK
The following text describes a protein:
Function:
Mast cell degranulating peptide. Antiproliferative activity against human breast and ovarian tumor cell lines in vitro. Inhibits granulopoiesis in rat in vitro. Causes histamine release from rat peritoneal mast cells in vitro. Has antibacterial activity against Gram-positive bacteria B.megaterium Bm11, S.lentus and M.luteus, and antifungal activity against C.tropicalis, C.guiller-mondii and P.nicotianae spores. Has hemolytic activity. The mature peptide inserts into the hydrophobic core of the bacterial cell membrane and increases permeability without disrupting membrane integrity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores.
Subcellular Localization:
Secreted.
Sequence:
MFTLKKSLLLLFFLGTISSSLCEQERDSDDEDQGEVTEQVVKRLVRGCWTKSYPPKPCFVRG
The following text describes a protein:
Function:
Probable ATP-dependent RNA helicase.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MNKYKNKYNTDNKFNNSKYIKNNQVELSKQELEDEEILKINDDEFNEGLNKQALFQQDDYVYKFKKQQKEEKIGGDEKTQIDNEKPEDFNITLKSIDFKSINLPSFKKRFLQSSTIKDIDSFEFINSTTEFIIENKSDDDNYYDDDDDDEGDKNKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKNKEIENKTYPNNCKIPIANTGESECLPNTLKLFFKKTQFPTPTLFQQYAWPAILTGHDIIGTSLPGSGKTLGYLAPMIPHCLARVDRGGKNKITGEKAPKQYTGILVLVLVPTRELGLQVHSNTLIITQLFGIKTSVIYGGISKNLQIEQLEKEKPQILISTPGRLIEMIENGHVDLSSVTMLVLDEADKMLSKGLIPQLKQIRGQIRPDSQNILFSATFPDSLKEVSKDWIKDPSIRLRIGSSELPKLNHIQQDAQLIAHHKKPRALIKLLSEPQFKEKKKTIVFFNKIKELKRISIMLLKSNIKHDTIFGNIDQELREKLINKFSSSRSTLLLSTDIIGRGIHIDDIFNIINYDFPRSLEQYCHRVGRAGRSDKVVNPKAFSFLTNSDSYLVEPFVQFLKDQHQNISIPFLKLCNENFGTKFEFTLSKRKQKKLAQKDDVEKDDEAYLAKYEKLIKKDRKKDSDDECKKFKSFKRKNIDSDSDNDSDSNSDNGKETKSKDKNKKFKKY
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Via its catalytic activity, regulates many processes, including cell proliferation, cell differentiation, inflammatory response and apoptosis. Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of pro-inflammatory cytokines IL6 and TNF-alpha. Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (By similarity). In the brain, epigenetically controls quiescence of neural stem cells for sustaining a protected neural stem cell population and maintaining a stem cell reservoir for neurogenesis. Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Through the catalysis of XRCC5/Ku70 trimethylation, regulates BAX-mediated apoptosis. SETD4-catalyzed XRCC5 methylation results in XRCC5 translocation to the cytoplasm, where it interacts with BAX, sequestering it from the mitochondria, hence preventing BAX-mediated apoptosis (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MQRRRGRTERARKRRRRSSGSRAVNESYRSEFIELRKWLKERKFEDTDLVPASFPGTGRGLMSKASLQEGQVMISLPESCLLTTDTVIRSSLGPYIKKWKPPVSPLLALCTFLVSEKHAGCRSLWKSYLDILPKSYTCPVCLEPEVVDLLPSPLKAKAEEQRARVQDLFTSARGFFSTLQPLFAEPVDSVFSYRAFLWAWCTVNTRAVYLRSRRQECLSAEPDTCALAPFLDLLNHSPHVQVKAAFNEKTRCYEIRTASRCRKHQEVFICYGPHDNQRLLLEYGFVSVRNPHACVPVSADMLVKFLPAADKQLHRKITILKDHGFTGNLTFGWDGPSWRLLTALKLLCLEAERFTSWKKVLLGEVISDTNEKTSLGVAQKICSDVIEETHAVLRKVSDMKEGTVSLRSQLSLVEALRMEELRILQASAEILSGLLAPFS
The following text describes a protein:
Function:
Involved in mitochondrial potassium homeostasis through the mitochondrial K(+)/H(+) exchange regulation.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLRNRLFKTPHQTGFQWRLGAPATGITIRNQPIRSYSGLRGNFLIDKRLSPVKFNKYSPSDIVFYNIGSSRLYSTETPTPSKVKEAPKQVAAEETKPTTVVKKPSIWQRVKGGVLHFWDGTKLLGVEIKISSKLVYKMAVGYELTRRESRQLTRTLKDIGRLVPFSVFVVVPFAELLLPIAVKLFPNLLPSTFEDAKDKEAKKAQLRKTRNEVSNMLRSTLKSGKFTFSNETRESKEFRDFFQKVRTSGQSPSREELIEVCKYFKDDITLDNLSRAQLVAMCRYMNLNAFGTDPLLRYNIRHRMRQIRRDDRAIYIEGINSLSIPELFNACNSRGIRTQGLSPAKLKEELSVWLDMRIKHGIPSVILMLSNAFSYGYNEGTYDSRWDALQDTLASIPDELYHETVVDMPTKQVSNKERLEILREQEELIEEEAEHVAEHPDLAKKQTEENKATSKPAVSAKSPESNIPKNERK
The following text describes a protein:
Function:
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
Subcellular Localization:
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Sequence:
MENGTLAQNYGATVAEAASPWKIIGAEQSTGGFQLIRCAACQTLFDISKQRHQSLVRCNQCNEATSMVRAPAGKKYVRCPCKCLLICHESASKIACPRPGCRRIINLAPKQSFQTPNSLPIFTCAYCSNQFLFNLPKSALNGCTYARCPDHDCKKVSSIGSPKFGRKWAIIFLMMSLVFTGAAVGLICTTSYTDESTKGGIFAVYVGMFLIAFLSFVRSLFYWTMRVSLIQGST
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB15 may act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MAKQYDVLFRLLLLGDSGVGKTCLLCRFTDNEFHPSHISTIGVDFKMKTLVIDGVKVRIQIWDTAGQERYQTITKQYYRRAQGIFLVYDITSERSFQHIMKWASDVDEYAPDKVQKILVGNKSDDVDKRQVATEQGVKLAQNYGMDFFETSAFTNHNITETFTRLAERVLAANKKDLDLLRMSLNDELNLAALEEEEGLRDGAAGDQQKQCWC
The following text describes a protein:
Function:
Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MEAPGEAEGEPEDGDSSCADVCFMDKGLRGISELSLDSTLHAINLHCNNISKIEAIDHVWNLRHLDLSSNQITQIEGLDTLTKLCTLNLSCNLITKIEGLEALINLTRLNLSYNHINDLSGLMPLHGIKHKLRYLDLHSNCIDSIHHLLQCLVGLHFLTNLILEKNGEDNPVCRIPGTSVMLQTLPQLRILDCKNIFGEPVGVSEMDSSQLQCFESLLDNLVSSDSPLNISEDEITDGVPVVTPPITEITALDQCASAPADAGLTSFISACPSSEPEKVSPENDFQNEMKLQKLDDQILQLLNETSNSLIDNVPEKDLRPKRDTDVTSESDFGNRKECNKKIPRRSKIPCYSRTIQTIKHHSKNNSPLTSCNRKMKQPFFKELYIRSSIVNSNILEESEEQKTELVKVDNGSSEDTTYRALIEQLDQEREKRWKAEQAEKKLMDYIDELHKHASEKEDLHSLALLTTDRLKEIIFKERNSKLQLEVMVHRLQSEVKKLTIELIKARDQQEDHIRHLRILEKALEKMERQKRQQQAAQMRLIQEVELKATAADREINLLRTSLHQEKEQVQQLHELLALKEQEHRKELETNEFFSDAEFQEALAKEIAKEERKHEEEIKEYQEKINVLNQQYVDLENEFRIALTVEAKRFKDVKDGFENVATELAKSKHALVWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKIQLISELAAKESLIYGLRTERKVWGRELAQQGSSLAKRRGKLEAQIESLCRENESLRKTNQRDNDALRIKCKIIDDQTETIGKLKCCLQEREDQIKILEGKIHEIEKCTQEQLDEKSSQLDDIVEKLEKHNARKEKLKQQLKVKELELEEIRKAYSTLNQKWHDKGELLSHLEMQVKEVKEKFENKEKKLRTERDKSLELQKDTMEKLHSMDDAFKKQIQAIVEAHQAEILQLANEKQKYIDCANSKVHQVEEEMRGLLEETCKNKKAMEEKINQLAIALKEIQQEM
The following text describes a protein:
Function:
Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYVAASWTVAIALAVALLFYKMPVANALASVVYGFFYGLWPIAWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFCFGAFLEGAAGFGAPVAITAALLVGLGFKPLYAAGLCLIVNTAPVAFGAMGIPILVAGQVTGIDSFEIGQMVGRQLPFMTIIVLFWIMAIMDGWRGIKETWPAVVVAGGSFAIAQYLSSNFIGPELPDIISSLVSLLCLTLFLKRWQPVRVFRFGDLGASQVDMTLAHTGYTAGQVLRAWTPFLFLTATVTLWSIPPFKALFASGGALYEWVINIPVPYLDKLVARMPPVVSEATAYAAVFKFDWFSATGTAILFAALLSIVWLKMKPSDAISTFGSTLKELALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGVSDLLLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCIVGVITTLQAYVLTWMIP
The following text describes a protein:
Function:
May have a role in maturation, such as during flavor formation or other metabolite production specific to aging tissues.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MIMLFLLFVALPFILIFLLSKSKNGGKNTLPPGPIGLPFIGNLHQYDTLNPHIYFWKLSKKYGKIFSLKLASSQMVVVSSSTLAKEVLKKQDLIFCSRPSILGQQKLSYYGRDIVFAPYNDYWREMRKICVLHLFSLKKVLLFSPIREDEVFRMIKKISKQASTSQIINLSHLMISLTSTIICRVAFGVRFEEEAHERKRFDFLLAEAQDMMASFFVSDFFPFLSWIDKLSGLTYRLERNFKDLDNFYEELIEQHLNPNRPKYMEGDIVDLLLQLKKEQLTPIDLTMEDIKGILMNVLVAGSDTSAAATVWAMTALIKNPKAMEKVQLEIRKSVGKKGIVNEEDVQNMPYFKAVIKEIFRLYPPAPLLVPRESMEKTILEGYEIRPGTIVHVNAWAIARDPEIWKNPDEFIPERFLNSDIDYKGQDFELLPFGAGRRGCPGIALGVASMELALSNLLYAFDWELPYGVKKENIDTNVRPGITMHKKNELCLIPKNYL
The following text describes a protein:
Function:
Plasma membrane transporter that confers resistance to toxic metalloids by mediating extrusion of arsenite (As(III)) and antimonite (Sb(III)) out of cells. Displays low-affinity As(III)/H(+) and Sb(III)/H(+) exchange activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSEDQKSENSVPSKVNMVNRTDILTTIKSLSWLDLMLPFTIILSIIIAVIISVYVPSSRHTFDAEGHPNLMGVSIPLTVGMIVMMIPPICKVSWESIHKYFYRSYIRKQLALSLFLNWVIGPLLMTALAWMALFDYKEYRQGIIMIGVARCIAMVLIWNQIAGGDNDLCVVLVITNSLLQMVLYAPLQIFYCYVISHDHLNTSNRVLFEEVAKSVGVFLGIPLGIGIIIRLGSLTIAGKSNYEKYILRFISPWAMIGFHYTLFVIFISRGYQFIHEIGSAILCFVPLVLYFFIAWFLTFALMRYLSISRSDTQRECSCDQELLLKRVWGRKSCEASFSITMTQCFTMASNNFELSLAIAISLYGNNSKQAIAATFGPLLEVPILLILAIVARILKPYYIWNNRN
The following text describes a protein:
Function:
Required for chondrocyte development and proliferation. Plays a role in myoblast differentiation and fusion. Modulates skeletal muscle extracellular matrix composition. Plays a role in skeletal muscle function. Plays a role in glucose homeostasis.
Subcellular Localization:
Nucleus. Cytoplasm. Secreted, extracellular space. Note=Secreted from smooth muscle cells into the muscle extracellular space.
Sequence:
MSQAGAQEAPIKKKRPPVKEEDLKGARGNLTKNQEIKSKTYQVMRECEQAGSTAPSVFSRARTGAETVFEKPKAGPAKSVFG
The following text describes a protein:
Function:
Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, 2-oxopimelate, oxaloacetate, citrate and malate. The main physiological role is probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate, respectively, and in lysine catabolism.
Miscellaneous:
MISCELLANEOUS: Present with 2840 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MTSIDNRPLPFIYQFTAGAIAGVSELLVMYPLDVVKTRMQLQVTTKGHPAVVAAKAAVDHYTGVMDCLTKIVKKEGFSHLYKGITSPILMEAPKRAIKFSGNDTFQTFYKKIFPTPNGEMTQKIAIYSGASAGAVEAFVVAPFELVKIRLQDVNSQFKTPIEVVKNSVVKGGVLSLFNGLEATIWRHVLWNAGYFGIIFQIRKLLPAAKTSTEKTRNDLIAGAIGGTVGCLLNTPFDVVKSRIQRSSGPLRKYNWSLPSVLLVYREEGFKALYKGFAPKVMRLAPGGGLLLVVFTNVMDFFREVKYGKKQ
The following text describes a protein:
Function:
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Subcellular Localization:
Cytoplasm. Note=Partially associated with the inner membrane.
Sequence:
MSDNDTIVAQATPPGRGGVGILRISGFKAREVAETVLGKLPKPRYADYLPFKDADGSVLDQGIALWFPGPNSFTGEDVLELQGHGGPVILDLLLKRILTIPGLRIARPGEFSERAFLNDKLDLAQAEAIADLIDASSEQAARSALNSLQGAFSARVNHLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEAQLNDVIADLDAVRAEARQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLREASDEVERIGIERAWQEIEQADRVLFMVDGTTTDAVDPAEIWPEFIARLPAKLPITVVRNKADITGETLGMSEVNGHALIRLSARTGEGVDVLRNHLKQSMGFDTNMEGGFLARRRHLQALEQAAEHLQQGKAQLLGAWAGELLAEELRLAQQNLSEITGEFTSDDLLGRIFSSFCIGK
The following text describes a protein:
Function:
Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.
Subcellular Localization:
Membrane.
Sequence:
MSKGPGLFSDIGKKAKDLLTRDYLSDHKLSVSSVTESGLALTTSTVKKGGYSSGDVAAQYVYKNTFLDVKVDTESNISATVAITDIVPSSKTIATLKYPNYESGKMEFQYFHPHAALSAAVGLNQTPPIDLSVTLGTPTFALGAEAGYETTSGKLTKYTAAITVTKPDSCASIILGDKGDTIKVSVIHYLDQSKRSAGVGEIARKFSTNENTLSVGGSYAIDSLSLVKVKLNNHGSLGAVLQHELAGKSLVTISSEFDTKALDKTPKFGVCLAVKP
The following text describes a protein:
Function:
ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose. Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins. Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively.
Subcellular Localization:
Chromosome. Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MAGSPNEDSEGSRITYVKGDLFACPKTDSLAHCISEDCRMGAGIAVLFKKKFGGVQELLSQQKKSGEVAVLKRDGRYIYYLITKKRASHKPTYENLQKSLEAMKSHCLKNGVTDLSMPRIGCGLDRLQWEHVSAMIEEVFDATDIRITVYTL
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAFTEIANLISSKNFKAILDYCQRQEIESKNIDLIKSYYGVYLLSYLINNDLINAKHLWKRIPNDFKQSNQQLKNIYTIIKSISQTNPTITYTSLSINIGDDYTPFITTLKENFQQRTFELISNAYSSITVNDCSSYLGISPEDTIKFTTSKCWEHDKASNTLKPVPIQKQSSELPTGNQQIRSLTSYVLFLEKST