lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin.
Subcellular Localization:
Secreted.
Sequence:
MMWWFLLIGLASAAATASSASSASFESRCQHFHKEIHLQNVHVLSTTYVPIGSNIPMVYNPPICGGTASSSISTIQFCQVALNVTTSDKSQFFMEAWLPSNYTGRFLSTGNGGLNGCVSYADMVYATQYGFATIGTNNGHFGDTGQYFLNNPEVIEDFAYRALHTGTVVGKALTKLFYPQGYKNSYYLGCSTGGRQGWKSIQRFPDDFDGVVAGAPAINFVNLCSWGSRFLKITGPPGSETFVTSAQWSAVHNEILRQCDALDGAVDGIIEDTDLCQPVFETLLCNSTAVDKTSCLTGVQANTVNEVFSAMYGLDGKWLYPRMQPGSELAASFIYYSGNGFKYSDDWYKYVVYNDSNWGHSTWTLADAAAAAAQDPFQISSFDGNISGFQKAGGKVLHYHGLEDAIITSDSSKAYYKHVADTMGLSPSELDHFYRLFPISGMGHCSPGTGAASIGQGSSTYAGDDPQDNVLMAIVQWVEKGIAPEYVRGSKMSRDGTIDYRRKHCKYPKRNRYVGPGKYTDENAWKCV
The following text describes a protein:
Function:
Involved in growth and development through its role in cytokinesis and polarized cell expansion. Required for plasma membrane internalization. May function in clathrin-mediated membrane trafficking, including plasma membrane endocytosis, essential to both cytokinesis and cell expansion. Acts as a negative regulator of basal resistance against bacteria.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Colocalized with clathrin at the plasma membrane.
Sequence:
MGRIFEYFVVCGLGPEMRTVDGDLGFHGMQTFYLPALLDQFPPTDQSPYPAPPPQLPTCVLPAGVEFHSSGFVSSDPASFPRSYPIVLTEGDGSKIFVSCIAFRDRVCEDIIEAYRLPPNTYADKCICLVSHAPNFRVLRNSLEEIFVLCFSSEGSCKPLWDIIAYMVSNVPLPTPGKDRVLFAVENCLLSVEAPPEDSLPQADISLQPLVQCLDVDNLIKLFTSVLVERRILIRSNKYSLLTLVSESICHLIYPFRWLQVYIPLLFFSGVDYIDAPTPYMMGLHSDVDTSNLAMDGVVVVDLDINQITTSEEIPQIPEPEFSTLRNDILKLLHPNVVAIDQLKGFGNSVEQCPKSLSKPWGEDHDLQLRVIFLKCFASILGGYRNFIENKVFSTDAFLKRRSRSTNQPPEPMLVQFLGSFAFLDYLERRLSSDEKSTNLLEKLQDAVGRGQDAMSILPKSSMEPEIITIAEPEVEESATRYTYDRFPASVRSEEQEEKRKQILAAASGALESNGRHPPSSPPGKNTKEDNFSSMERAAERERMVLDIQVKLQGLWLRLLKLGSDEDPLSSFEYGTILALIESDAEGIGGSGFIECIREHLYSGWHGQLSEEQFIAVKELLKMAVGRAASRSDLSTVRDALEVSAEMFKKDANNVSDYVQRHLISIPIWEELRFWEGYFEYLMEQPANESVNYATLVTARLIIVASHMAGLGLPDTEAWNMIETIAEKQKLGYKLLIKLRGFLSHVQQLRVGYWGASSFKQQAISAGLPSPRPKDVSVSDETQQPSEASGRSWVQSMFSRDTASRANSFSRVRKWVSDNASSDITAAAQKKIQTNVRVLKGHGGAVTALHSVTRREVCDLVGDREDAGFFISGSTDCLVKIWDPSLRGSELRATLKGHTGTVRAISSDRGKIVSGSDDLSVIVWDKQTTQLLEELKGHDSQVSCVKMLSGERVLTAAHDGTVKMWDVRTDMCVATVGRCSSAILSLEYDDSTGILAAAGRDTVANIWDIRSGKQMHKLKGHTKWIRSIRMVEDTLITGSDDWTARVWSVSRGSCDAVLACHAGPVQSVEYSPFDKGIITGSADGLLRFWENDEGGIKCVKNITLHSSSILSINAGENWLGIGAADNSMSLFHRPSNAGTKVSGWQLYRVPQRTAAVVRCVASDLERKRICSGGRNGVLRLWDATINI
The following text describes a protein:
Function:
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
Sequence:
MSRLRIFADSNPTTPHFDSRDGEQIATELRKIGVTFERWHASQPVEPGASPEQVMAAYRADIDRISAERGFKTVDVVSIAPDNPKREEMRAKFLDEHFHKEDEVRFFVAGSGLFTLHVDAQVYEIECVKDDLIAVPDSTLHWFDMGPEPHFVAIRFFTEPDGWVGHFTGTEIAKQFPRYAPEKPPKAS
The following text describes a protein:
Function:
Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.
Sequence:
MTYDIKGKTAIVTGSARGIGKCICSDLLKKGANVVVSDTAEDVGNETTAEFQKEFGESRVVFIRCNVTKEEDLQNLYSKAIATFGYVDIVVNNAGILNEENWKLMMEINVTGLIRSCQLALDNMSTKNKGKGGVVVNLASVAGLMAGEGSKVYHASKHAVYGYTRSQYLTQGTDNVRFNCVCPFLVDTALAQDWDNSNRTFLTSDLIEKLKAHMLKTEDIAEAVIFLIEDESNAGKAYLVTPFQKWDYYEQPSVLPF
The following text describes a protein:
Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
Subcellular Localization:
Cytoplasm.
Sequence:
MIGRKKLEEHYITIAEAKELLERRHAEGLAENPEEPMFYEARVSLEHAERFAKLKPEQARELKEKLMGLFDWINERIAAKLVDILPEDYLDIRVIFAKEEYMPTPEEAEEIIKVS
The following text describes a protein:
Function:
Vacuole-specific MYO2 receptor required for vacuole inheritance. Binds simultaneously to MYO2 and to VAC8, a vacuolar membrane protein, forming a transport complex which moves the attached vacuole membrane along actin cables into the bud. Once the vacuole arrives in the bud, VAC17 is degraded, depositing the vacuole in its correct location.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MATQALEDITERLLIRSQEAILQLDLWIQRQQRSSICQTTDQESLDKLSQQYNQYMSQLNSLYVRSESVRDKLSKEQQRRLITEDNEHQRIEDLVREFQDITLRLNELATVPNEAPNDSPQSQSTRSSLGSFQPRPLKIIERQRLCMVTPSKPPKKSVGFNPINEVDCPSKTNSLPCSPKKQPARNRTLRAAKSHDTGLNKSKKPSSSDTYESFFKNRQRLSLTFFDEMDDEDFDSDQDTIILPNISTPPHVGVTAKGAEFEPLRRYNSHESILSNKPAPSKSLNLGSFSASFFRPSNPTFGTSISNVQVNCHPTVAATMAPSRNGPRISSSKALLSSFIARSDTHTVKENNTNLKHASFMDKFNSSLSTISESFQSKRGRKNKGMNEERISNHNVAQEQKNNMDISVSIEELQDALNTELLF
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 plays a supporting role to the catalytic subunit OSGEP in the complex.
Subcellular Localization:
Nucleus.
Sequence:
MELLGEYVGQDGQRQRLRVPCEAPGNADHFQGLLSGVARMKELVAELFGSPVQGEAQDRVAAAPEEALDGDDEDDAEDENNIDNRTNSDGPTAKRPKPPS
The following text describes a protein:
Function:
Catalyzes the isomerization of D-erythrulose-4P to D-erythrose-4P. Involved in the degradation pathways of erythritol and D-threitol, that allow M.smegmatis to grow on these compounds as the sole carbon source.
Sequence:
MALRVVVGADDAGYEYKEALKGDLAADDRVTEVIDVGVGADEDTAYPHVAVAAARLIAEGKADRALLVCGTGLGVAISANKVPGIRAVTAHDSFSVERSVLSNNAQVLCFGQRVVGLELARRLAREWLGYEFDPTSKSAEKVQAICGYEPATS
The following text describes a protein:
Function:
Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The C-terminal RRM domain and the zinc finger motif are necessary for RNA-binding.
Sequence:
MSRKVSISSLTLSEPMTKPARVQVNPEDIDDLDKTQQVNNHQYNIWYSKSLSDANNKSTTKSKYRVRISTDQGFTKANKNTHICLFFSRGCCYLGSKCQYFHRLPKESDNFKPTQDCFGRDKTANYRDDMDGVGSLNKVNCTLYVGGIHIKPNTEQLLVKNFQEFGTVEKVRVLQGKGCAFVTMKTENQAQFAKEAMQSQSLVEGSNEVLYVRWANEDKNPAAQKQEKKRQQELAYDTVKQLLEQESNKKPRLENGAVNRIETINIDDESEDEGAVEDDEADDDIEETRVNSLSAGVKKNVSTHQANGTPESSSTSDENDHNTILRNSLLKDISRLKKKMVYKREEPYLTNLLVDYSSDEDDD
The following text describes a protein:
Function:
Required for correct meiotic chromosome segregation.
Subcellular Localization:
Cytoplasm.
Sequence:
MKEMINLDSSSEPSIVTKQFSVEECLSKLKEQHCYVPMRTIGRLRLRKSSDQTEKKCWKEKLMKIRSELEELWEQSMMYEEQKELTQLGEMLDRLWDKHINSEGSKSETISDTAISGNDDTMEKRLEQFSDDTLQDTLETEKNLNSKTSESLKSPTLSYPFDLDSLDKRIFKLESKIGYADEPLSELLNKCMEKLEIVEQDPQFWQSRIESWKQLLAKDFLKHHERNLCSIEKQTTLKNSSLKELCTEEDIVIMLEICSSQLPFVEQYMPILPLLLERLKSLQNMHTDAAEAISSWQGSKDVMMTMQSELNEWKNTVERLDHSKFYTQSVEEMRRLSDTVTQLEKRVLKLQ
The following text describes a protein:
Function:
Hepatic sulfotransferase involved in the maintenance of bile acid homeostasis and energy balance. Catalyzes the transfer of sulfonate group from 3'-phosphoadenylyl sulfate (PAPS) to the 7-alpha hydroxy group of primary bile acids to form 7-monosulfate derivatives in the pathway of bile acid elimination. Displays high catalytic efficiency toward cholate, chenodeoxycholate and their glycine and taurine conjugates.
Miscellaneous:
MISCELLANEOUS: The short isoform L-STL2 appears to be a minor form. It is likely non-functional as it lacks a conserved C-terminus region required for PAPS binding and sulfotransferase activity.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MTDEFLWIEGIPFPTVYYSQEIIREVRDRFVVRDEDTIIVTYPKSGTHWLNEIVCLILTKGDPTWVQSTIANERTPWIEFENNYRILNSKEGPRLMASLLPIQLFPKSFFSSKAKVIYLIRNPRDVLVSGYHYFNALKQGKEQVPWKIYFENFLQGKSYFGSWFEHACGWISLRKRENILVLSYEQLKKDTRNTIKKICEFLGENLESGELELVLKNISFQIMKERMISQSCLSNIEKHEFIMRKGITGDWKNHFTVAQAEAFDKAFQEKAADFPQELFSWE
The following text describes a protein:
Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS
The following text describes a protein:
Function:
Putative transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'.
Subcellular Localization:
Nucleus.
Sequence:
MPRKRKSRGTRDVAEILRKWREYNEQTEADSCIDGGGSKPIRKAPPKRSRKGCMKGKGGPENGICDYTGVRQRTWGKWVAEIREPGRGAKLWLGTFSSSYEAALAYDEASKAIYGQSARLNLPLLPLCQARLLHFLMNLKFVHVRIQMQDLVLVRSD
The following text describes a protein:
Function:
Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MALPAARSALSARAFIRPAAALNAAASSSRYLSTTTPRHDAPVATTPGNSETALPVPLPGIKFLSMPPVTPHPPTHGIHVATLHLQAHHPYNLDLVSQFAVHSAHSLNIPTSLPAFLPREKSLYTVLKSPFVKKKAQENFERRTHKRAIKVYDADREAIDLWLRYLRQNALPGVGMKAYIHEWVELGFGRKEAEGQNEIEMEVEEKRIQDAAAELVKALSEGEGEDQAEGVQKIVDAAREEKPAEKLKEEEAKSS
The following text describes a protein:
Function:
Involved in glucose repression of glucose metabolism genes.
Subcellular Localization:
Nucleus.
Sequence:
MSMSTPMPTPTSLDTKKMPPKEKKNKDDRPYKCTFCDKAFHRLEHQTRHIRTHTGEKPHACTFPGCVKRFSRSDELTRHLRIHTNPSSRKRKNKNQNMMINPNATTATTTGPAGMAIPTSNLPPGSYAIPNTAIPFSIDRNGNHVYHQPYPVYFVPHANGYMQPMVQTQGVTVVPNTDQQQQQYYQQQQQQYQFQERPQHQQQQQTNIGTNNHLQQNGSAVFSLPSSPTMASAQTPNSGTSSSSESIKLAPLSIPNNISRSQQQQQQQQQQQIPKSESSTSLYSDGNKLFSRPNSTLHSLGSSPENNNASGPLSGVPTPSFSNLNDYFQQKSNSNNSRLFNASSSSLSSLSGKIRSSSSTNLAGLQRLTPLTSTTNNTNNTTTSNTTNNNMTKPSIIPKQPSSTSLNLEFYNGNNQQQQNYHTHKKSRPNSPSQTPIHLSSSRKSANNSFIISPNETPLQTPLQSPQLKPYQDQPPTNVNINVSAPSDTFIGTAVTEKLNNISSIAGNGTQLPPIRSVLSFTSLVDYPDPKQKNVAPPVVDTTNVARGETNGSNGNNSNAKPMSLTNLLS
The following text describes a protein:
Function:
Component of the transition zone in primary cilia. Required for ciliogenesis.
Subcellular Localization:
Cell projection, cilium. Membrane; Multi-pass membrane protein.
Sequence:
MEAKVHRQHQRHRRTEARQRRLEREAVATGAAAPTPTTPERAEALDCATALNEGVVSADPGGSGGTPSSAGRISAQSSADSIELVGSPSQTSQQTVVLVNGHAPPGQEEGEEESPLGAGNTRDSPPPPKQSDGSRNSSGDAMSLRETLQQLPATHHHRSRRTHSPADPDASFHRGILGYMDRELKQSSPTPSAPAGTGNGTGNGTSTGASRKQQSLSDPQASPAQRSLRSRSSFDKSPRRKRSKSESRRRRERKLIAAGEMEVRQANETLMRYLKQCSDMHDASLSGELEIDQSLEERRVHRKTKSQRDKRGQLISKLYSAGGISSILKELADDIAPADGEEIYNPFTPVVSPTDDAPAHIDKMFLQTSSGYRPVEHSYYKRSFLGAAVRGSAGISASGGGGGCAGGGGGRLDGISAAELGGAGRLFRSSGSHAHGGDRMGGNGSGRGSYGDTRCLLDADFNRNGITSNIQLACVVQRIWLLISNICHGLLAGLALAHLLFVLSSHPMDWAKVINGMSLAGETVSSTAQPPAASTPSAIDIDSGDRGTESGESSSPSAAASGLALISDYAGFAEIYLNTFYCLAIICLVSVFDRMDICRWSFSNASELISFRWLIITMIYVATIILAICSDSIDEKLYLFNNNANITLTQQEMLSNSVQSVWSSLSVTRSIAAISGWIMIGLTPQEDMLYEHLVDLTKYQLTNN
The following text describes a protein:
Function:
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MKGWNVIVIGGGHAGLEAAWAAAKFSRVALLVGNPATVGRMPCNPAVGGPGKSQLVFEVQALGGLMGRLADDTAIHTRMLNASKGPAVQSLRVQNERDAYAERAQDVIFGHSEIEIVRGEAADLEQDGQGGWVVVTSDGRRLHARSVVLAAGTFMRGVTWYGRQSRPEGRQGEPPSRFLSAPLERGGHVLKRYKTGTPPRVRADSVRFADLLEIPADPQPRGFTGTPGPRAAESPTWQTHTTPQTHALIQENLHESPMYAGDIEGLGPRYCPSIEDKVVKFAHHDRHLLFVEPDGVQTSEVYLQGFSSSLPPRLQDELVRTLPGFEQAVIQRYAYAVEYDVVDSTELTLNLESKKLPGLFTAGQLNGTSGYEEAAAQGLVAGTAAARRSLGLDEQVIGRETSYLGVLLDDLVFKGSDEPYRMMTSRVEHRLLVRQDNADERMTPIGHALGLVDDAELIRVQEKYARVQSGIKSLSKQRMQGQTADAWLRRPELSLADVETLGATLPAELGASEREAVEIRVKYAGYIARAESQLRSEAKARELSLSGVNFAGITALSNEAREKLTRLQPQTVEQASRISGVRHADISALLVHLKGQRVGS
The following text describes a protein:
Function:
Essential for cuticular modification during development.
Subcellular Localization:
Secreted. Note=Secreted as part of the seminal fluid transferred to females.
Sequence:
MSASASACDCLVGVPTGPTLASTCGGSAFMLFMGLLEVFIRSQCDLEDPCGRASSRFRSEPDYEYDFIVIGGGSAGSVVASRLSEVPQWKVLLIEAGGDEPVGAQIPSMFLNFIGSDIDYRYNTEPEPMACLSSMEQRCYWPRGKVLGGTSVLNGMMYVRGNREDYDDWAADGNPGWAYNDVLPFFKKSEDNLDLDEVGTEYHAKGGLLPVGKFPYNPPLSYAILKAGEELGFSVHDLNGQNSTGFMIAQMTARNGIRYSSARAFLRPARMRNNLHILLNTTATKILIHPHTKNVLGVEVSDQFGSTRKILVKKEVVLSAGAVNSPHILLLSGVGPKDELQQVNVRTVHNLPGVGKNLHNHVTYFTNFFIDDADTAPLNWATAMEYLLFRDGLMSGTGISDVTAKLATRYADSPERPDLQLYFGGYLASCARTGQVGELLSNNSRSIQIFPAVLNPRSRGFIGLRSADPLEPPRIVANYLTHEQDVKTLVEGIKFVIRLSQTTPLKQYGMRLDKTVVKGCEAHAFGSDAYWECAVRQNTGPENHQAGSCKMGPSHDPMAVVNHELRVHGIRGLRVMDTSIMPKVSSGNTHAPAVMIAEKGAYLLKRAWGAKVURVDATWTLHRVI
The following text describes a protein:
Function:
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSLTRLHPRLLSRTNRIFSSQIRYYAAPGEGTIPAAKKKYVPTSGTYPLGFKAGSAHVGVKASNTRFDDLALIASDTPCAGAAVFTTNKFQAAPVTVSRDMLRKRKGEGVRAVIVNSGCANAVTGRGGIEDAISMGQETDQCFVKDNNGKDDGKEYHIAGMTKGAGMIHPNMATLLGIICTDAPVSAGPLQTALTSAITKSFNSISIDGDTSTNDTVALLANGAAGGQSITSTSSEDFQAFQKTLTEFAIDLAKLVVRDGEGATKFVTIRVTNAATYKDAHKVASTIARSPLVKTALYGKDANWGRILCATGYAEGVDSVIPEETSVSFVPTDGSEELKLLVRGEPEQVDETRAAKILEAEDLEINVRLSENKGYKEEAVFWTCDFSHEYVTINGDYRT
The following text describes a protein:
Function:
Involved in rRNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKRSYEEAEGSNADGQEQNQAQKRNRNPHNRFNPKNIAKRQKTTQKINDGNLSQIKKRVRAIERLLEHKNEKLPANVRNDLERELQAHKQRIVDESDRKLRSKMISKYHMVRFFERKKAMRLAKQLMKQLDETKDEAEIARLKADLHIAEVDLDYALYHPHMETYISLYPKPKDEAAEKDEKSSAAHHLHSSRPPMWTTIEKARQEGKSALEKIRDRRPERDFSKPTSKKTAKKSSSQSEERPAKGKFGKTEEESANESDDGGFFEED
The following text describes a protein:
Function:
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Domain:
Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
Sequence:
MISEDVVQKVIELNDIVDVISGDIKLKNSGRNYFGLCPFHHEKTPSFSVSQDKQIYKCFGCGEAGNVVTYVMKTKNVAFPEAIKILAERVNIDIEEDKKENTNNPKDKIYKINVDAARYFFNNLIINKNAINYFLNRGVTKSIIKRFGLGYSKDSWDGLLRHLKTKGYTELDMLSAGLIIRSKNGSYYDRFRNRVMFPVFDYRGKVIGFGGRVLNNAKPKYLNSPETMVFKKGINLYGLNYAVKENKDRVLIIVEGYMDCITLHQYGIKNSVASLGTALTTNQARLLKRYADKVIISYDSDTAGQLATQRGLEILKDVGLGVEILTVPDGKDPDQFVKAHGKEAYLKLVKEALPLIEYKIKISKQDLNIGNKRQVIQYIDRYIKIIENLDPVEKDMYIRRLSEETNIEIQTLYDQLNKKNQNSRKNGKEVNMLEAFGQKLYLEPAYIRAERFILQLMFNYNNIYEYIKNSINEQDIIEETHKAIYKYIKDTLEDSNIQNKKLHIETLCNKNVETSKEWVNILNTNFIYKEDESKKFIDDAILNIKKYKLEKYKENLLKKIKEYEAQGKLDETIKMSQELIKVKKTLGAMK
The following text describes a protein:
Function:
Acts as a regulatory protein involved in the regulation of numerous cellular processes. Together with its homolog TMC8/EVER2, forms a complex with CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 and reciprocally. Together with TMC8, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER. Down-regulates the activity of transcription factors induced by zinc and cytokines. Also plays a role in thermal sensation by inhibiting the M-channel (KCNQ2-KCNQ3 channel) current in primary sensory neurons (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Localizes to the ER, Golgi and nucleus membranes in keratinocytes.
Sequence:
MAQPLAFILDVPETPGDQGQGPSPYDESEVHDSFQQLIQEQSQCTAQEGLELQQREREVTGSSQQTLWRPEGTQSTATLRILASMPSRTIGRSRGAIISQYYNRTVQLRCRSSRPLLGNFVRSAWPSLRLYDLELDPTALEEEEKQSLLVKELQSLAVAQRDHMLRGMPLSLAEKRSLREKSRTPRGKWRGQPGSGGVCSCCGRLRYACVLALHSLGLALLSALQALMPWRYALKRIGGQFGSSVLSYFLFLKTLLAFNALLLLLLVAFIMGPQVAFPPALPGPAPVCTGLELLTGAGCFTHTVMYYGHYSNATLNQPCGSPLDGSQCTPRVGGLPYNMPLAYLSTVGVSFFITCITLVYSMAHSFGESYRVGSTSGIHAITVFCSWDYKVTQKRASRLQQDNIRTRLKELLAEWQLRHSPRSVCGRLRQAAVLGLVWLLCLGTALGCAVAVHVFSEFMIQSPEAAGQEAVLLVLPLVVGLLNLGAPYLCRVLAALEPHDSPVLEVYVAICRNLILKLAILGTLCYHWLGRRVGVLQGQCWEDFVGQELYRFLVMDFVLMLLDTLFGELVWRIISEKKLKRRRKPEFDIARNVLELIYGQTLTWLGVLFSPLLPAVQIIKLLLVFYVKKTSLLANCQAPRRPWLASHMSTVFLTLLCFPAFLGAAVFLCYAVWQVKPSSTCGPFRTLDTMYEAGRVWVRHLEAAGPRVSWLPWVHRYLMENTFFVFLVSALLLAVIYLNIQVVRGQRKVICLLKEQISNEGEDKIFLINKLHSIYERKEREERSRVGTTEEAAAPPALLTDEQDA
The following text describes a protein:
Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MNGKGLEKKKKTIVKGSMNEKKFALSTAFMKGIGWLGVNVAYAQEDSDDDATKSEGVVDDESDVEVEDDKSGQRSADSAQGGNEQEEEKAEEEAAPLIKSSEFAETNILFTTNDVQALPTGTLSKCLIGFSNIGELDFIVDSIEGSVRYPADYNYFIQNTTFYYAFAPHDSLASRPFGLVFTVSYRDADGNTFQTVLYNDTVTFVEGKSGVDGEMVFMYVFLAACAALVVLLVRQLVVARMSKKSAKPTFETGTQNADIDMEWIPKENLVIAGGSQSPKRSPRNRKSKAESS
The following text describes a protein:
Function:
Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes.
Subcellular Localization:
Nucleus. Chromosome, centromere. Nucleus, nucleolus. Note=Localized to the synaptonemal complex lateral elements in late diplotene oocytes, while it is absent on the synaptonemal complex of leptotene, zygotene, pachytene and early diplotene oocytes. Localizes to centromeres in dictyate oocytes (By similarity). Detected in nuclear granules and sizable aggregates (By similarity). Localized in a cage-like cortical structure around the entire nucleolus, consisting of a meshwork of patches and filaments.
Sequence:
MSEDGAQTAEKMDTHTQYYLESLIIDALKGKGFQKIIELFDGKVIFSSQFHNKLLLSQLDKLINKELDRNEFKHVSVLMKCIQHFCKNDCQESSTLIHQGLVSKMVLWFERTVDFLRISKEATLLTLVEDFYDSALVICKCNCEDGKRQLLDSFLIRLGHLVTEKWVACHLRLEALRTINCILDSISREDKKKLHCSEDLCELTKDLARTIQEAGDYDIQVAISEALCRMMGKKFRDSFVHQWFEDNFLADAFKEIKDKEFETDCRKFLNCLNSRHQSNKGVYTFPCITVFTDLDELKKPQDENMENFWIDFNAGSQCVSFYIHNTEGSLWDSVRLLKESVNNYTLKENDGQQMLGIYLKDPQVINTNDVTKVKIYFEPKHDIKSAIKRVFEDINEIHSNPVELDSTEGLIDIGNSLASHTVITTATTFKQWKRNQANKMDSASDILGSQTSEHSSTTKTSSANRSVQKSLSNADSHEIVIESVPLEAVITIADEQPNTAQFQDDMDDAIFQGAASDVPAKDSSQEIIIITEASADKEFAAKKTQGIFQFQGYSDTLASDQVSDAKKKILLPKQSTERATPASRYRASMNSPLQRTSSAYRSHLFCESNEVTSNTESERSWIQDFKNKSAVKSADYSCEKTRNKSKRKVLPLASESGDDEKQVDTTETVARFTSRKEMHRPEDINPKSPHSAELKLPGISALLTPGDSRSQSKSDYRYQSAIDDQDIMDPVEEASSPEMSIDHNKEPKNGHDEVYASGPLNRSVDGNNIYHAADTLQHATGKRKHKTCEREEIPFKPRKLFSSTEKNVNRSAADSEDSEDVFYSESHDQDLAEASVLSAFDSFTKELKRKFLTRYKRIENRANHVLKSSHQQVSTVLNEIHQCRLQKINHFNKIVVHELSSLEAEVQALKQFEKETLDFWEDQYVKMNTFCSSQTQRIKTMDSALLETISNLKNVIQKTTKEEVSNTEEHIQNKLLK
The following text describes a protein:
Function:
Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPASLRSPLAIILGAIPGALARYYATIFLAGLFGNDLPYATFLINFSGCVGMGLVVTLATQPALMSPDLRLLLAVGFLGSYTTFSTYALEVTSLWRMGQLGQGVLYGLGSLGIGTIGVLLGSLIARRLTI
The following text describes a protein:
Function:
Has bactericidal activity.
Subcellular Localization:
Secreted. Cytoplasmic granule.
Sequence:
MKILCLLFAVLLFLFQAAPGSADPLFPDTVACRTQGNFCRAGACPPTFTISGQCHGGLLNCCAKIPAQ
The following text describes a protein:
Function:
Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Could play a role in mother cell lysis with CwlC.
Subcellular Localization:
Secreted.
Sequence:
MVTIKKDFIPVSNDNRPGYAMAPAYITVHNTANTAKGADAKMHAKFVKNPNTSESWHFTVDDSVIYQHLPIDENGWHAGDGTNGTGNRKSIGIEICENADGDFEKATSNAQWLIRKLMKENNIPLNRVVPHKKWSGKECPRKLLDHWNSFLNGISSSDTPPKETSPSYPLPSGVIKLTSPYRKGTNILQLQKALAVLHFYPDKGAKNNGIDGVYGPKTANAVKRFQLMNGLTADGIYGPKTKAKLKSKLK
The following text describes a protein:
Function:
Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates.
Sequence:
MNPTELDSDVFAQDVDNQKARELREMLNTQDFVFAPGMYHALDARLAEMTGHDAAYMSGYSTVLGQFGFPDLEMVTMTEMVENAKRMVEATNLPVIADCDTGYGGIHNVRRAVREYEKAGVAAVHIEDQTTPKRCGHIAGKQIVSREKAKARFEAAVDAKQSEDTVVIARTDAYGSSNGDWDEHVERGRIYADAGVDIVWPEMPNPSREDAVAYAEEIHETHPDLKLAFNYSSSFAWSEEEDPLTFQELGDLGYKYIFITLFGLHSGAHAVYEDFKKLAEQDEEGQFDLEQRYLDHPTESHHELSFVSRYQDIETEFDPEARRRIEESEGFSEEQADPITSNDDD
The following text describes a protein:
Function:
Transcription factor that binds to the promoter and the enhancer regions of target genes (By similarity). Regulates expression of genes involved in fat metabolism, including ech-1.1 and fat-5. Has a protective role in response to infection by the Gram-negative bacterium P.aeruginosa. Required for the activation of infection response gene irg-1 following P.aeruginosa infection. Required to prevent P.aeruginosa ToxA-mediated lethality. May also function in concert with transcription factor zip-11 to mediate immune responses, independently of the pmk-1/p38 MAPK pathway. May act together with the bZIP transcription factor, zip-2.
Subcellular Localization:
Nucleus.
Sequence:
MSGNRKRNTSEPREDDEDDYSTKRKRNNEAVNRTRQKKRQEENDTAEKVDELKKENETLERKVEQLQKELSFLKEMFMAYAKNDGNDGPPPPPPPSSSAV