lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
Sequence:
MACSCLLMASMQTLPGPGAFRTENGTLYLAFQEYYEAPQDPHNMADALSQTLSNSSLSQTLLSQTLISHTFLSQTLLSNSSLSHSLTLSQNSQTLLSQTLLSQTLLSLLSLTLSHSLKTLSNSFFSLKLFSLKLLDVFSLSHTRTSTREDGGDGQDGHEDRVWDVKWSPTGAVLASSSGDQTVRLWTREARDWVCLSTLEGPQKGTIRSLSWGREGNYLAAASFDSTTCVWEKGPSGFECFATLEGHENEVKGVAFSASGDYIATWFADEEEFDCAAILAEHSQDVKAVAWHPTRDLLASCSYDNTIRFYRADPDNADWICCDTLSDNQSTVWKICFNADGSRLAAVGDDRTLRVYQAFPPGNPQGAALPAHSSIYAPCLRNTLHSAINRLVCSDFAGIVTPSASDDKWKCIATITGQHTRPIYSVDWDPETNILATAGGDNIVRLFRETAVQPDTNTPSYELIGQFQAHDQDLNGLAWAPNQPDLQHRLLATCADDGLHVGNHKS
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine diphosphate (ThDP) into mitochondria.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MKMKMEDGGLERAAVDAIAGAVAGGISRSVVSPLDVIKIRFQVQLEPTSTRLGPLGGTHVVSKYTGIWQATRDILREEGLPGLWRGNVPALFMVMPYTAIQFVVLQKFKSVAASYQEGDKNPGHLSTTMAYASGAVAGTAATVGSYPFDLLRTIMASQGEPKVYPTMRSAFMGILRSRGITGIYAGLTPSLVEIVPYAGLQFGFYDTFKKWTSALNERKGLPKDPHAENLSGFQHFVCGLGAGTFAKICCHPLDVVKKRFQVEGLQRHPRYGATITHKEYKSMRDAISRILQKEGLAGLYKGTLPSVIKAAPAAAITFVVYEYLADYLKDLATSES
The following text describes a protein:
Function:
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Sequence:
MLNAQQFLNQFSLEAPLDESLYPIIRDICQEVKVHGDKALKMYNLTFDHTKTDHLEISHEQIKAAFDTLDEKTKQALQQSYERIKAYQESIKQTNQQLEESVECYEIYHPLESVGIYVPGGKASYPSTVLMTATLAQVAGVENIVVVTPPQPNGVSQEVLAACYITQVDQVFQVGGAQSIAALTYGTETIPKVDKIVGPGNQFVAYAKKYLFGQVGIDQIAGPTEIALIIDETADLDAIVYDVFAQAEHDELARTYAISEDAQVLKDLESRIAKALPNVDRYDIVSKSIANQHYLIHASNFDEACHVMNTIAPEHASIQTVNPQPYIEKVKYVGALFIGHYSPEVIGDYVAGPSHVLPTNRTARFTNGLSVNDFLTRNTVIHLSKDTFEQIADSAQHIAHVEALYNHQQSILIRQS
The following text describes a protein:
Function:
May be involved in vascular wall and kidney homeostasis.
Subcellular Localization:
Secreted.
Sequence:
MELAPRASSVPLLLLLLLGLSTGAVTDWPAEEGKEVWDYVTVRKDAHMFWWLYYATNPCKNFSELPLVMWLQGGPGGSSTGFGNFEEIGPLDSDLKPRRTTWLQSASLLFVDNPVGTGFSYVNKSDAYAKDLATVASDMMVLLKTFFDCHKEFQTIPFYIFSESYGGKMAAGIGLELYKAIQQGTIQCNFAGVALGDSWISPVHSVLSWGPYLYSVSLLDDQGLAEVSQVAEQVLDAVNKGLYKEATQLWGKAEMVIEQNTDGVNFYNILTKSTPTSAMKSSLEFTQSHLVHLYQRHVRHLQRDALSQLMNGPIRKKLKIIPEDCSWGGQSTNVFENMEGDFMKPAISIVDELLEAGVNVTVYNGQLDLIVDTIGQEAWIRRLKWAELPKFNQLKWKALYSDPKSSETSAFVKSYKNLAFYWILRAGHMVPSDQGDMALKMMRMVTQQE
The following text describes a protein:
Function:
Enhances the ATPase activity of DHX15 in vitro.
Subcellular Localization:
Nucleus speckle. Nucleus, nucleolus.
Sequence:
MFGAAGRQPIGAPAAGNSWHFSRTMEELVHDLVSALEESSEQARGGFAETGDHSRSISCPLKRQARKRRGRKRRSYNVHHPWETGHCLSEGSDSSLEEPSKDYRENHNNNKKDHSDSDDQMLVAKRRPSSNLNNNVRGKRPLWHESDFAVDNVGNRTLRRRRKVKRMAVDLPQDISNKRTMTQPPEGCRDQDMDSDRAYQYQEFTKNKVKKRKLKIIRQGPKIQDEGVVLESEETNQTNKDKMECEEQKVSDELMSESDSSSLSSTDAGLFTNDEGRQGDDEQSDWFYEKESGGACGITGVVPWWEKEDPTELDKNVPDPVFESILTGSFPLMSHPSRRGFQARLSRLHGMSSKNIKKSGGTPTSMVPIPGPVGNKRMVHFSPDSHHHDHWFSPGARTEHDQHQLLRDNRAERGHKKNCSVRTASRQTSMHLGSLCTGDIKRRRKAAPLPGPTTAGFVGENAQPILENNIGNRMLQNMGWTPGSGLGRDGKGISEPIQAMQRPKGLGLGFPLPKSTSATTTPNAGKSA
The following text describes a protein:
Function:
Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
Sequence:
MVVKIGIIKCGNIGTSPVLDLLLDERADRPNIDVCVVGSGAKMNPDEIERAVPTMLEMERDFVIFISPNPGAPGPAKARELLSAADVPAMIIGDAPGLRVKDEIEEQGLGYIIVKADPMIGARREFLDPTEMASFNSDVIKVLAFTGAYRVVQNTIDAMIADVEAGKAPELPQVVIDTDKAVEAAGYTNPYAKAKAMAAYEIATKVADIDVRGCFMVQDPDQYIPIVASAHEMLSAAAKLAIEAREIEKANDTVLRTPHGKEGKTLSKKDLLAKPE
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of a 2'-O-methylguanosine in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
Subcellular Localization:
Mitochondrion.
Sequence:
MISIFKILSSPKPATTTTNIINPINIINGIRYFSSNQEDYPLFKKPVFNGKVLRGGRKVFKNDLIYSKKESHYNNNNNSNNNSNNNNNNNNSNNRNNNNFSNNRNNNNNRNNNNNNSNRNNNNSNDNNFRNNNNNNRRTEYYKNDFDSSKYISNKPEIRIFDLHEQAVYGINPVWVALSSGNRTFNALYVCGTLLPKLKELGIDIKNIENSKREYISDFDHNYGRETNQIEDENQDEQYSNQHDEQEQNEYEEEQEEEKVQEEEEDNNNNNNIKKTTFNRYNDRKNLVALKEIVKNSFKLKIPVRSVNKGTLDSFSKGRPHQGIILDASPLTLLNIDFLEKFDINERVNKRMNGGGGGGGGGGGNKINNDKYPLWLVLDELWDPQNVGAIIRNCSFFNIDGVVISNKNSSPITPAASKSSSGACESFVINRTESIEGFLKSSQRNGWNVVGTSLDDLNENQPCLDINQIKLDQPTILILGNEGFGLKPSVLEICNKTIKIVGGNYKIDSLNVSVTSGILIHTLLSSGTLPK
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins.
Sequence:
MLQATCARIARRFVWRNRMPRRLFIGLFLLPLPLFAAPPKDELAYAVGARLGMRLQQEMPGLELSELLLGLRQAYRGEALEIPPERIEQLLLQHENATTETPRTTPAEARFLANEKARFGVRELTGGVLVSELRRGQGNGIGAATQVHVRYRGLLADGQVFDQSESAEWFALDSVIEGWRTALRAMPVGARWRVVIPSAQAYGHEGAGDLIPPDAPLVFEIDLLGFR
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the nedd8 pathway: processing of full-length nedd8 to its mature form and deconjugation of nedd8 from targeted proteins.
Sequence:
MSDPLIVSYNDSAIYQSDINILKSNQWLNDSIISFYLEWLKDGGEDNKNKIPNQVLLLSPSVVFCCSFVESEQEIQLMFEQPLSLKTKEVIFFPLTNNRDPNVIGGGTHWSLLIFIKSLNKFIYYDSINSFNSSDAIFIISKFKFLLSSPPPKTNLKEFLINQKTPQQQNGYDCGLYVLSIIEELLKLIIKENENNKGEENKISYKDLLLSEFTNELLFKEITPNYIKDKRVEILNTILKLKK
The following text describes a protein:
Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MARFADDLPSRYGGGAGGGGRGGPGAGRGGARGGGAPGGQRMYKQSMAQRARTMAIYNPNPVKQNCLTVNRSLFIFREDNLIRKYLLLNPHTPFEYMILATIIANCIVLALEQHLPASDKTPMSERLDDTEPYFIGIFCFEAAIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGSDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGVEFYMGEFHKTCFKSDTDERVADWPCGQEAPARTCPNGTQCKEYWTGPNFGITNFDNILFAVLTVFQCITMEGWVDILYSTNDVVGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVEKRQEFLKLRRQQQIERELTGYLEWICKAEEVLLEEEDEIAEEKSPLDVLKRGKIKKVKNDLMGAEEGEDPFADMSSVAPPSSPFGRASVKSSGKMDSSSYFRRKEKRIRFFIRRMVKAQSFYWIVLCLVGLNTLCVAIVHYDQPEWLTRALYTTEFVFLGLFLTEMTLKMYGLGARNYFHSSFNCFDFGVIVGSIFEVIWDIIKPGASFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFEDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVRRGMFSSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEQEEAANKKLALQKALEVKEVSPMSAANISIAAFVKQNRDPLSRRSSISSIQSPREQHRSSKSMSVWEQRTNQLRRHNMKSSSEALFSELNPEERLRVSTLLHLHPDMKTHTDRPLVVDGKNGDQTGRPSEGGQEEAEAPRPDEVGDSFRAHSRKHHRHRDRNGNGGDSRRERHHTHHSRSRENAADGSREGTEGFDAGQGCRHHCQASSPEEGAGDGRRGGEPGGHRHHHSRPPREGNGIMGNGAQGECRGRGGDMGDAIAERRGRNSCKARAQPTLEGGDCRKQGVYREGQVGVEENSPACSPVLQTRSSLTLSEKQEDADNLKNSTRASHAGLNSNAIRIPVTVTAPPGETIIPMNNTDDDIFQLSEEKKDLDEEEGTNGPRQILPYSSMFIFGQTNPLRRLCHYVVNLRYFEMCILMVITMSSITLAAEDPVQANATRNNVLKYLDYVFTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFACSGTKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKGLEKDCRGQFLDYDRDDVTAQPREWKKYEFHYDNVLWAFLTLFTVSTGEGWPVVLKHSVDATYEDQGPSPGFRMETSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKAMSDCSLEKNERACIDFAINAKPLTRYMPENKKSFQYKMWKFVVSPPFEYAIMTLIALNTIVLMMKFYGAPDLYKSMLKYLNIVFTGLFTLECILKIIAFNPLNYLKEPWNVFDFVTVIGSITDILFTEINNKMINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIELNEETAINHHNNFQTFFQALTLLFRSATGEAWHEIMLACLSNRPCDKLSGTTEKECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDASILGPHHLDEFIRVWAEYDPAACGRICYRDMYKLLRFISPPLGLGKKCPNRVAYKRLVKMNMPIADDNTVHFTSTLMALIRTALEIKLASGVLAQRLCDADLRREINKVWPNLSPKTADLLVTPHKCNCFSLLFSADNELTVGKVYAAHMIFDYYKQNRAKKLQQQNPTGASQNKLGALFRPVLPFTHIHASEPPMPSPKQPLPPQPEPVTKAEAPPTTPSTNADRTSSRDTLNTIKHSQSGDVSQASQRPKARRRLQRGQSEDVQYSSKPQEQLELRQVEIISDSERFPSLESHCRAASLPRLNRSHPRHAPGTHLAPIVDLSPIKRSASSLTPQSHREVELRDYDLERDGQLPAGPGQIQEEERVHHHHHHHRCHRRRDKDREKKHRSLEKAASGQPGSTTADVFPRERPRERDRSRPLERRHHSSAGEKQRYYSCERYGSRESCQARSAGPSRSASPGEGQDSGSLKQVRFVSGAAKVAPPTGTSTAGRGRRQLPQTPLTPRPGVAYKTASSSALQGSGVASGHQARLSRGLSEHDRHPVGHSEGLLSITCMGSDPNLNRQHLDSSRQALFGESEDFQDALSSHGGGRFANTAASSTTLQRGAAEAATATTMQGRAAGVPNGYHFTLGVNAASGSGNRGTGNLREREKDDWC
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MAATAAASRSQSSKKKPKKKTAKNPEVERLSALPWNESLPVEDPFAIFGGTNNLEGGFLSLEEIDESEYGFVIPEPGKDEKEAAEEPFSSSKSRNRKRKAADGVSGDDSEDYSEENAEDEGKAKKKTKKKKRKAKKKKTENKKDGEQLSAEEPGNNASEDVQGDSVVDDAEFYVWNELRLHPLIMKSIYRLGFKEPTPIQKACIPLAAHQGKDVIGASETGSGKTLAFGLPILQRLLEERXKAAKKLSENGNAVEKGAQGSPLRALIVTPTRELALQVTDHLKEVAKVTNIRIIPVVGGMSTEKQERLLKRKPEIVVGTPGRLWELMSGGDEHLSELHSLSFFVLDEADRMIETGHFHELQSIIDMLPMTSGSGGENSNMTKNCATVPNLQKKKRQTFVFSATIALSADFRKKLKRGALKSKKSMLDGMNSIETLSERAGMRADTAIVDLTNALIMADKLEESFIECREEDKDAYLYYILSVHGQGRTIVFCTSIAALRHISSLLRILGTSVWTLHSQMQQRARLKAIDRFSGNEHGTLVATDIAARGLDLPGVRTVVHYQLPHSAEVYVHRSGRTARASADGCSIALISPSDGSKFASLCKSFSKETLQRFPVDNMYMPEVTKQLSLARQIDKILRKDSQERAKKSWLERNAESVELVIEDNESEEERVSSHKKKKISSIHLKQLQQELNVLLSRPLQPKTFSHRFLAGAGVSPLLQHQFEELARKKLVENRSHNESKRSKFVVIGQDCMEPLQALRRAGPEMRMDLKELAEKRRNIENIRRKRKEEKKRLRDQRRKERKRLKNGSG
The following text describes a protein:
Function:
May be a component of the TFIID basal transcription factor complex.
Subcellular Localization:
Nucleus.
Sequence:
MAKDKEKKGNLTGFLFGNVKESGELDVEENDQVFKDLKKDLELFAKSSQHISFKKTIGIDEDDKNAVTDSVIVPDKNALDYEDIDEVAEEIQSTENEINKLNADKLANAAIARLQQQHKEREEQQRLKLLEQQQRQLSKKERRKQRKQVGSKQPLQIKKKPSVDDFDFDEEEEQQQQKSTRSEDEDDDDISSASSLSSSSASSSASSSRSPSMSRSASDIESDSMSDSSRSSGSSISSRSSISSSSSRSDSDSDGGGGGGGGGGGSHRRRHKEKKPKKKVTMKAGSYEVVKSILETPEMFTPEDQEFKVFVSGKSSEGFILKFSQLFAPKFPDKPTRKKSRKTRFSTPQTLNDDSIETDELLLWNQPSKKQPPPSIIKKPITEIDSITKQLLKSNAGITSSTGGGGEEDTLTSSNTTTPTLTSMQLYQAAAEEDEEYVPEPLRETEDEEIMTMFYMVPDSNYHSLQQVNWEDNIIWDEESLIKFKKSDHFNQFYLSSDNQQQNIIIKEAITMPVEINDLTPNLNKNSKQTSSSSTTTSTTTTTSTTTTTTTTTTATTLSSTSTSTTTQRNNKNKNKNNNNNINNSSKLFGLDHISEKEEIMDTDSQNLLQQPLSQEKDKEKEKDKDKAQNEQHIQTIVNNKKNSTTNNNNLTNNNGNNNNTNNNNNNSNNNSNNNNNNNNNNKQNNNKEIDEIMKSNIDKWSLFPISNQELENGDWIDNIIWDESMVPEKIQQVSMLILDLNDREMYFEEHIEKKEHNNGESGSNGDQQAPVKKKSKKKLALEAAQAAQAAALERAQAAARAANGQTMSFEEQLQKDKEEDERKEREEREQSQREIDKFNLSNDKFYRPVRKPPPRPPNGSTKVVIQHSLPGIKLSLVKTHLTKEDLIYAHRPRILFPSNVPFRIIIYNKEGSLSGDLSSSSNNLLLNSSTNSIMGGHNMRGSINGGMMSSSSSSSSSSSKKSLHKSDLSARDGRLVLIEYTEQHPPLVSNVGMGLRIRNYYKKKNTHDTGPKDLNFEDGELVMLDNNEESPFLGDINPGQTIQSVVNNLFKVPIHKHNSANTDFLLVKSRDGKRWYIRDVGPIYAAGQILPEVEVPAPNSRNANMFLKSRLQAYIYRQFLKKSNPQRRLKITDICSAFPSQSETSIRKRLKDCADFQRGGDDSGWWTVKDNFTLPTEEEFQKLVTPEAVVSFESMLIGLQRLQDNGIIHFTAPGTIPTILGNLDDEDPIKKSIKPVEDELSITPWNLTGSFLSAMQGKGRLQIISDDPTGREDEYSYLKMPQKVVNQKQKAIKLALQKNQVTGTDADLRKLSLSASKTVLLELGVDEETINKLARWQRIDLVRKKSSEAALASNSNAAMTKFARGSRYSLDHQNLQYKEQCQLVFDNQIKAIAGKGDDLYDEDLDADLLKDLEDSLFGDSNQSQNQNQNQNQNQNQSNNNNNKSSSKSTGKRSRSLFSRDESDEEEDNEEEEYNKLMGTKNKDEESKAKAKAKAEEEEIKAKAEEAKAKAKAKAEEDDLTQGDRVFVKRTTLFQKPDGSLFKRIEIIRDPKVVQDYQKKKHDQFLQDRKKFGKQNEEDEETKKQRRRIQERLRRLKKNDQREDSFNMNSSNSSIGATIGSSNMINISAGNIPVSNINNNNYNNNNNNNNFSLNTSSSNKPIPPHRSSSSGIGSSGSNNNSNTDRDQTRISIVMPNQQANSDSNSSSSTKIRIGQSSSSSSSSSSSSGHPRSSDREHRSSEHRSGEHRSSEHRSSEHRGSEHRSSEHRSGEHSSHHRSSEHRSGDREHRSSDRGDREHRSSEHRSSEHRSSEHRSSEHRSGDKEHRSDREHRSSEHRSGDREHRSDREHREHRSGDREHRSDREHREHRSERSRNSSSGSSSSSRDHRDSHHRNSTGSSSDSHSSSHHSSSNRDSNHNGGSSSNNNNNNSNNNHNNNNNSNNNNNNNNNNNNNNNINNNNNNNNNINNINNNNNNNINNINNNYNNNNNNNNNNNNNNNNNNNNNNINNNENNNTNNLSNSTNQSPTLSQSGIIIRYNGSNSGNSNNTNGGNNRTEDQSVLNTPLSASSSGSNRKKRTLDQSNSESPSLSSTTLDGSDKSSRRNRVRKDGSGADVELSNIFERILDKLRTNDEFIAFRHKVTPKLAPDYHKVIKNPIDLTTMRDRNRHWEYKSKNQFIDAIKLMVANCFEYNEKRFSHLLPIAEKLLTSTLQLLAPFDSQIGDLEKSIEQTNLKQSSSSLLLSVDHTNGSTPSTPITLNTPITPNLPSNSPFFPPVDPPSKAHHSAEDEEIDIVSLYESGVSPSVKNNFN
The following text describes a protein:
Function:
Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia.
Sequence:
MENYQKLEKIGEGTYGVVYKAKDLSHSGRIVALKKIRLEAEDEGVPSTAIREISLLKEMNDPNIVRLLNIVHADGHKLYLVFEFLDLDLKKYMEALPVADGGRGRALPEGSGPELGRLGLGDAMVKKFMSQLCEGIRYCHAHRVLHRDLKPQNLLIDREGNLKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGGRQYSTGVDMWSVGCIFAEMCTRKPLFPGDSEIDEIFKIFKLLGTPNDQEWPGVSDKTCFPDFKPSFPKWQRDMSQPLCTNLDDNGLDLLELMLVYDPAGRISAKQACAHPYFEEGSSAYSGRGLGATYKPTNGYH
The following text describes a protein:
Function:
Catalyzes the deamination of D-threo-3-hydroxyaspartate (D-THA). Also exhibits dehydratase activity towards L-threo-3-hydroxyaspartate (L-THA), L-erythro-3-hydroxyaspartate (L-EHA) and D-serine.
Sequence:
MQDTLLTLDTPAAVIDLDRMQRNIARMQQRMDAQGVRLRPHVKTSKSVPVAAAQRAAGASGITVSTLKEAEQFFAAGTTDILYAVSMAPHRLPQALQLRRRGCDLKLIVDSVAAAQAIAAFGREQGEAFEVWIEIDTDGHRSGVGADDTPLLLAIGRTLHDGGMRLGGVLTHAGSSYELDTPEALQALAERERAGCVQAAEALRAAGLPCPVVSVGSTPTALAASRLDGVTEVRAGVYVFFDLVMRNIGVCAAEDVALSVLATVIGHQADKGWAIVDAGWMAMSRDRGTARQKQDFGYGQVCDLQGRVMPGFVLTGANQEHGILARADGAAEADIATRFPLGTRLRILPNHACATGAQFPAYQALAADGSVQTWERLHGW
The following text describes a protein:
Function:
Catalyzes the conversion of taxusin to 2-alpha-hydroxytaxusin in taxol biosynthesis. Catalyzes the conversion of 7-beta-hydroxytaxusin to 2-alpha-7-beta-hydroxytaxusin in taxol biosynthesis.
Subcellular Localization:
Microsome membrane; Single-pass membrane protein.
Sequence:
MDAMDLTVAKFKEFTQLQSSAILLTVVSGIIVIVILLLRSKRRSSLKLPPGKLGLPLIGESLSFLWALRSNTLEQFVDKRVKKYGNVFKTSLLGQPTVVLCGAAGNRLILSNQEKLLSRTVSDRVAKLTGDTSISVIAGDSHRIIRAAVAGFLGPAGLKIHIGEMSAHIRNHINQVWKGKDEVNVLSLARELVFAISASLFLNINDREEQHQLHKTLETILPGYFSVPINFPGFAFRKALEGNSKRRKHFSVLQEKRRRDLSVGLASRTQDLLSVLLAYEDDKGNPLTDEEVLDNISALIDGSYESTSSQMAMLLKLLSDHPECYEKVVQEQLEIASHKKEGEEITWKDVKAMRYTWQVMQETLRMFAPVFGPRGKAITDIHYDGYTIPKGWQLSWATYSTHQNDTYFNEPDKFMPSRFDEEGGRLAPYTFVPFGGGRRKCPGWEFAKTEILLFVHHFVKTFSAYTPIDPHESIWGRPLPPVPANGFPIKLISRS
The following text describes a protein:
Function:
Probable E3 ubiquitin ligase acting as a positive post-transcriptional regulator of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity. Might be involved in the quality control that degrades misfolded proteins (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The RING-CH-type zinc finger domain is required for E3 ligase activity.
Sequence:
MEISPADSLSISGAAASEVVSEPSVSSSSSSSSPNQASPNPFSNMDPAVSTATGSRYVDDDEDEEDVCRICRNPGDADNPLRYPCACSGSIKFVHQDCLLQWLNHSNARQCEVCKHPFSFSPVYADNAPSRLPFQEFVVGIAMKACHVLQFFLRLSFVLSVWLLTIPFITFWIWRLAFVRTFGEAQRLFLSHISTTVILTDCLHGFLLSASIVFIFLGATSLRDYFRHLRELGGQEERDDDVDRNGARAARRPAGQANRNLAGEGNGEDAGDQGAAVGQIARRNPENVLARLDIQAARLEAQVEQMFDGLDDADGAEDVPFDELVGMQGPVFHLVENAFTVLASNMIFLGVVIFVPFTLGRIILYHVSWLFAAARGPAVAASLHLTDTGLSLENITLKSALTAVSNLTSEGQGNGLLGQLTEMMKVNGSELNGANNTLSVATDLLKGSTVGASKLSDITTLAVGYMFIVFLVFLYLGIIALIRYAKGEPLTVGRFYGIASIVEAVPSLLRQFLAAMRHLMTMIKVAFLLVIELGVFPLMCGWWLDVCTVRMFGKTMSHRVQFLSISPLASSLVHWVVGIMYMLQISIFVSLLRGVLRPGVLYFLRDPADPNYNPFRDLIDDPVHKHARRVLLSVAVYGSLIVMLVFLPVKLAIRMAPSIFPLDISVSDPFTEIPADMLLFQICIPFIIEHFRLRTTIKSLLRCWFTGVGWALGLTDFLLPRPEDNIGQDNGNGEPGRQNRAQVLQVGGPDRAMAALPVADDPNRSRLRAGNVNTGEEYEDDDEQSDSDRYNFVVRIILLLLVAWVTLLLFNSALIVVPVSLGRALFSAIPILPITHGIKCNDLYAFVIGTYAFWTTISGARYAIEHVKSKRTSVLLNQIWKWCGIVFKSSVLLAIWVFIIPVLIGLLFELLVIVPMRVPVDESPVFLLYQDWALGLIFLKIWTRLVMLDHMLPIVDDSWRAKFERVREDGFSRLQGLWVLREIVFPIVMKLLTALCVPYVLARGVFPMLGYPLVVNSAVYRFAWIGCLSVSLFCFCAKRCHVWFRNLHNSIRDDRYLIGRRLHNFGEAALANQNQNQSSEDAGDGVLIGREGDVDNGLRLRRAIQQEA
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MADPRKTAAAGAASSASTLILLQICSRILTFVLNQLLVRLVSPSVFGLANIQLELLISTILFLSRDAFRTILIRNECLATSSSTMGQVKISGARKGSTNSVHNLSLLPIPIGFTLTMAACTVYIRYISPEAMRFVPTFRVSIALYALGALSELVCEPLIIRAVRLGHPTWRVKAEGIGVFVKTTSTIATIVIVPRLNIASLQTYLVDERATALFAFGIGQASYSFVILAVLMVLFFQEYGVSDTLDLYIARPDSLRGAEKLKGTTRTIWFDRRTLSLCATMAQQGLLKHCLTEADKFAVARYATLEDQGGYALASNYGSLVARILFQPIEETTRIVFSAQLPALDCTTNQRTSSRPDLSEDAVERVGSMLCGLFRMHILLACCMTAFGAPLSTPFLYIVAGPRWALETSAPTILAAYTWYLPIMGINGIVEGFVQSVASEAQVNRYSRVLLVASAGFIMALAMMNVLVDRSNVMEFVLGKTALVWANAFSLAIRAAWCWSFVIAYVGRAATNKKHTFDVSPRAALPSSSTLVMFALVAAMLRVATPTLMPNTSQLSLTAHAGRWSALRLLLPTLTLTASCLATVLCTVILVERHQLQHALRSLGRAGNQTRKSQ
The following text describes a protein:
Function:
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Sequence:
MNTDERYKLLRSVGEECIQESELRNLIEKKPLIRCYDGFEPSGRMHIAQGIFKAVNVNKCTAAGCEFVFWVADWFALMNDKVGGELEKIRIVGRYLIEVWKAAGMDMDKVLFLWSSEEITSHADTYWRMVLDIGRQNTIARIKKCCTIMGKTEGTLTAAQVLYPLMQCCDIFFLKADICQLGLDQRKVNMLAREYCDLIGRKLKPVILSHHMLAGLKQGQAKMSKSDPDSAIFMEDTEEDVARKIRQAYCPRVKQSASAITDDGAPVATDDRNPVLDYFQCVVYARPGAAATIDGTTYATYEDLEQAFVSDEVSEDALKSCLIDEVNALLEPVRQHFASNEEAHELLEAVKSYRKDGATLPLAETALPAAPAKPHACMWMPALLKVPLDVAEGMIKVTKDFIAAHPEGTVTLVLPDWSAVASDEITGVEKDISAALQVNCALLKAYGLPSSVKIVTENEVILGNCDDFWVSVIGIARKNLLSHVEELYGGEVRNAGQVIAALMRVATALMLSVSHVISTSLDGHINAFAREYTKERIDCVQTLEGRIPALHRPGAAPAVLGADDVLYLDDNDMDIRRKIKKAYSAPNEEANPVISVAQHLLAQHGALSIERGEANGGNVSYNTPEALVADCGSGALHPADLKAAVLQLLLDRSAQARALLNGELKKNMTVLRNAEKKMAKKR
The following text describes a protein:
Function:
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. Could also be permeable to glycerol.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
SIAFSRAVFSEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLAIGTLVQTLGHISGAHINPAVTVACLVGCHVSFLRATFYLAAQLLGAVAGAALLHELTPPDIRG
The following text describes a protein:
Function:
Involved in DNA repair and RecF pathway recombination.
Sequence:
MRQKGIIIKAVDYGESDKIITILNEHGAKVPLMARRAKKVKTGLQAQTQLFVYGLFIYNQWRGMGTLNSVDVISQHYKLQMDLYVSSYAALAAETIERSMDEGDIAPYNYQLLQFVLEKIESGTSAQLMSVVVMLKCMKRFGFTASFNRCAVSGNDTQADLIGYSFKFDGAISRQEASKDVHAVILSNKTLYLLDVLQKLPIDKMNSLNIHQEIIDEMSDIILMLYREYAGMFFKSQKLINQLKRLEQ
The following text describes a protein:
Function:
Major component of royal jelly, a substance produced in the hypopharyngeal gland containing proteins, free amino acids, fatty acids, sugars and other nutrients, which is fed to developing larvae by worker nurse bees. All larvae are fed some royal jelly early in their development but it forms the principal source of nutrition for larvae destined to become queen bees (Probable). May play an important role in honey bee nutrition. However, its role could not only be associated with larval development, because high level of mRNA is found in both forager and nurse honey bees. No antimicrobial activity (tested on E.coli, B.subtilis or Paenibacillus l. larvae) has been observed. Together with MRJP1 forms the apisin complex that polymerizes into a fiber network at low pH, increasing the viscosity of royal jelly. Larvae destined to become queens are reared in special large cells oriented vertically; viscous royal jelly acts as an adhesive preventing the larvae from falling out.
Subcellular Localization:
Secreted. Note=Royal jelly.
Sequence:
MSKIVAVVVLAAFCVAMLVSDVSAKTSISVKGESNVDVVSQINSLVSSIVSGANVSAVLLAQTLVNILQILIDANVFA
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.
Sequence:
MSSLAPRAPPSSTIHNTPSPRQRPTDQDEPRPTIIGPDDGPEPPFPVKLYGKVEHGFKRGSRELGCPTANLPATLTNNPALERNGVYFGWASVWITSPNPLPPVIKPMVMSVGYNPVYGNKSRTIEVHVIPTFDQDFYGETVKVIVTGFIRPEYNYSSKEALIQDIEIDKTAALQSLKRPDYQAFSEDEFLLKN
The following text describes a protein:
Function:
Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer. Positively regulates neuronal differentiation. Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (By similarity). Important for the correct development of primordial germ cells in embryos. Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes. In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: Major form in the testis.
Subcellular Localization:
Nucleus.
Sequence:
MPKVFLVKRRSPGVSVRSWDELPDDKRADTYIPVSLGCLLRDPPEDCRSDGGSSSGCSSSAGEPGGAESSSSPRAPEPETPELHDAQGTDGHLAAMQRPVARSKIKFTTGTCDNSVIHNCDLCGKSFRLQRMLNRHLKCHNQVKRHLCTFCGKGFNDTFDLKRHVRTHTGIRPYKCEVCNKAFTQRCSLESHLKKIHGVQQQYAYKQRRDKLYVCEDCGYTGPTQEDLYLHVNSDHPGSTFLKKTSKKLAALMQNKLTSPLQENSTLSEEEEKK
The following text describes a protein:
Function:
Toxin that inhibits rat ASIC3 channels (IC(50)=13.8 uM). Also able to bind T.californica muscle-type nicotinic acetylcholine receptors (nAChR), and human alpha-7/CHRNA7 nicotinic acetylcholine receptors.
Miscellaneous:
MISCELLANEOUS: A synonymy between H.magnifica and R.crispa is controversial; MISCELLANEOUS: Negative results: does not inhibit rat ASICa channels.
Subcellular Localization:
Secreted. Nematocyst.
Sequence:
MDYQRLLFLFAVAMVITTTVALPQDTALMDGQLQKRGTPCKCLGYTGVYWFMITRCPNGHGYNLSCPYFLGVCCVKK
The following text describes a protein:
Function:
Has a role in the DNA replication-monitoring S/G2 checkpoint system. It is responsible for blocking mitosis in the S phase. It monitors DNA synthesis by interacting with DNA polymerase alpha and sends a signal to block the onset of mitosis while DNA synthesis is in progress. Phosphorylates rad60 and dna2.
Sequence:
MEEPEEATQATQEAPLHVSQNIAKQVVNNENVFMKLVMTRMLDGKTEVIPLTTDVHNGFWRFGRHKSCEVVLNGPRVSNFHFEIYQGHRNDSDESENVVFLHDHSSNGTFLNFERLAKNSRTILSNGDEIRIGLGVPKDEISFLCQVPVKHSRDSQKNMIKSENSHYEIIRTLGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEMFQREIDILKSLHHPGVVQCHEIFENDDELFIVMEYVEGGDLMDFLIANGSIDEQDCKPLLKQLLETLLHLHKQGVTHRDIKPENILITNDFHLKISDFGLAKVIHGTGTFLETFCGTMGYLAPEVLKSKNVNLDGGYDDKVDIWSLGCVLYVMLTASIPFASSSQAKCIELISKGAYPIEPLLENEISEEGIDLINRMLEINPEKRISESEALQHPWFYTVSTHEHRTPPSSSEHEATEQLNSSS
The following text describes a protein:
Function:
Required for sporulation.
Subcellular Localization:
Forespore outer membrane. Note=Forms a ring around the forespore.
Sequence:
MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFLLETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK