lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating the chromosome architecture. Promotes chromatin compaction by converting H4k20me2 to H4K20me1 leading to transcriptional repression. Required for X chromosome dosage compensation by enriching H4K20me1 on X chromosomes and thereby reducing X-linked gene transcription in hermaphrodites throughout development. X chromosome specificity is mediated by the recruitment through proteins of the condensin-like dosage compensation complex (DCC). Required for the enrichment of H4K20me1 on autosomes in meiotic germ cells leading to their compaction in a DCC-independent mechanism. Involved in 3-dimensional chromosome organization by strengthening the borders of topologically associating domains. Involved in the regulation of growth, fecundity and body fat metabolism downstream of the TOR complex 2 and the protein kinase sgk-1 pathway. Also involved in male tail development.
Subcellular Localization:
Nucleus. Chromosome. Note=Specifically localizes to the X chromosomes around the 300- to 350-cell stage in hermaphrodite (XX) but not in male (X0) embryos. Requires sdc-2, sdc-3, dpy-26, dpy-27 and dpy-28 for X chromosome localization. Colocalizes with X chromosomes during interphase, but is diffusely distributed during mitosis. Localizes to all autosomes but not to X chromosomes in pachytene nuclei.
Sequence:
MRSTTFDKNSGAPEEPRRPRGPRTPDGEPTEANERPCSSSSSLSNDSFVPAPQGPQNGHTSSSHDNDYSEYRPRRGPKTPPLPPPDEPVKQQQQQQPIVAPYSYYPTYGSSTGYPYPYPTMMMPQQGIPGPSQHPATPSYYIQHPPPPSMSNGAPYYPHMNPSPYYQPRPNYVTQPPAPIIPPPQPPVMTASAAAAAYRDRLPPPPPKPPMPDLRTKEPIGIRSWNGSGIPPPPILPPVACLSSTMSPGMLRSPVPRERFNSVESNGSFSLHPPPPVPPPAKKPLNMDVRELLNGAHQTTVESVKKDPPAPQPRPRPIPVPPTTSYNSSFCGLLPPPPVPPDLRASAASAAASPPMVQDASFSSVLTPKTKAPEKIPSPPATVTSSTDSLEHMQRKRKKQQETEEQEKAAKKAKRHQEERERQKIEAEKRKKAILEEAAKVTRPPAEKKPPVVVEETIRAVPFVFKQEMPLPFVLAAAAAAAKEPETRPEPRPEPKQNGYHVKQAEPLQAEPPQNGYRLAAAQALQHEPRQASEPLQNVQPEPSKQASELVQNGYAAPQEPRRATPPPEPLRNELPKHSDLLNVSKPSEPAEPPKPSDAPREPEVAAAEAVIPEPSPAVSVEEPPRREERAASMAGIPPPPPTSSRHSPVPRREDRAEFMARSTPPAPGKDRKSLGGRMAMWRNKKNKTASMVGPPEPKELPAVVEVEAIVEPVVEDQPEPVVSEELKPTEPEPVEPEPMEVEPVVAKEVVEEVVEEVVETQEPWVPLSECSRSSSLELLAELPPPPRASEPPPPPPPPVATAPVPASMEEDEIIDIETIDEITSTSTKKPEKVEKIKKAPVVTKAALKMVGRPKKTPGRRRKKDRGASPSPSPSPPPPPETTLTPIVLPRKKQRIEKKKLTPPPPQQAPVTSHTPPPVEQLMSRKKQIMMEHSSLDHIQFKLIEIELAAKRRKAEAAAKAAAAVEQKDEKAEEVENRETPPGPSTSMRSSSLHTPNTSEEDEVIFVEPSTLEKPERRNGTTEERVMTADQRAMFDAKIEEARRSRMSTRDCSVVSTLGPVKSKASQRLHDIIEGKEELEDSMDDPTNNNGTLAGILYPMRSERAESVSSNHRSEGAGGSMSLKHHLARKNELKEEANVARRSEILKAVVKRQREIGVPTTLMSKSAIELVEEDEKERKNHKNNKTLSHPDYVRSKNEAEKAEFHGKGGTMRITNRNLKMLTRQFDLPKMSSRFRKFVRIRRHPNGMATIISCDYNQIKQHLGPNEMKHFERQFVRLGFAENNGVPLFAIGVMENAAEALHDQFEWLAKNSPNTQVKVGSLTNKQFIETMPMKKYYESAMETLDMGTFRFGPLMSLSMVGTKNEEAGGNFKEMLDALNAAPFLGPIMPWGDFSEVQGIKEDTSDDGPIFWVRPGEQMVPTDGKNRSTEPRHPLATRGNDRRETAFNDRTNAHADQVRESTEDDPTTTTTTTTTTSSSSSSSKSKKSAKSDPTFVKSTAAVGVLQGIRNPDANDDDEYYEDERKAVKEVIVFDAHDLHKVAHHLAMDLYEPPVSQCHRWVDDAILNTMRREGIRYAKLELHENDMYFLPRNVIHQFRTVSACSSVAWHVRLRHYYDVDQPASLSDPQFECDSDYSDDGDFDD
The following text describes a protein:
Function:
Transcriptional regulator which binds to the E box motif 5'-CACGTG-3', when in a heterodimeric complex with mxl-1. Involved in the control of lifespan in response to dietary restriction, the decline in protein homeostasis associated with normal aging, germline signaling and may overlap with the insulin-like signaling pathway. Plays a role in autophagy. Involved in promoting infection by the microsporidian pathogen N.parisii, possibly together with transcription factors pha-4 and zip-10. In response to neuronal injury, mdl-1 is targeted by sdz-33 for ubiquitin-mediated degradation, probably thereby reducing levels of mdl-1-mxl-1 heterodimers, allowing free mxl-1 to form complexes with tdpt-1 and thus inhibiting tdpt-1-dependent sumoylation of ets-4.
Subcellular Localization:
Nucleus.
Sequence:
MEQQLNLGHLLTAARLLDIGALDISSLDLGALTSTSSSPGSSSPAMFDLSNESELRSLFCGKLKVDKKQSSCASNASTSSQPYCSSPPARKSSKHSRTAHNELEKTRRANLRGCLETLKMLVPCVSDATRNTTLALLTRARDHIIELQDSNAAQMKKLNDLRDEQDELVAELAQLQADEEVAQATSQACQTLSQSRPESRASSFTSTSSRDSPCYLEYSPSSKPMDSHKPTIIDLYAEGLIPRGPITFPRPLVYPHNVFDLMNLPPTPFDVSQFLPINLQV
The following text describes a protein:
Function:
Participates in abscisic acid-regulated gene expression during seed development. Regulates the transcription of SGR1 and SGR2 that are involved in leaf and embryo degreening.
Miscellaneous:
MISCELLANEOUS: The truncated abi3-6 mutant lacking the DNA-binding domain is unable to localize to the nucleus and is an embryo stay-green mutant; MISCELLANEOUS: [Isoform 2]: Due to a cryptic intron removal.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Predominantly found in the nucleus.
Sequence:
MKSLHVAANAGDLAEDCGILGGDADDTVLMDGIDEVGREIWLDDHGGDNNHVHGHQDDDLIVHHDPSIFYGDLPTLPDFPCMSSSSSSSTSPAPVNAIVSSASSSSAASSSTSSAASWAILRSDGEDPTPNQNQYASGNCDDSSGALQSTASMEIPLDSSQGFGCGEGGGDCIDMMETFGYMDLLDSNEFFDTSAIFSQDDDTQNPNLMDQTLERQEDQVVVPMMENNSGGDMQMMNSSLEQDDDLAAVFLEWLKNNKETVSAEDLRKVKIKKATIESAARRLGGGKEAMKQLLKLILEWVQTNHLQRRRTTTTTTNLSYQQSFQQDPFQNPNPNNNNLIPPSDQTCFSPSTWVPPPPQQQAFVSDPGFGYMPAPNYPPQPEFLPLLESPPSWPPPPQSGPMPHQQFPMPPTSQYNQFGDPTGFNGYNMNPYQYPYVPAGQMRDQRLLRLCSSATKEARKKRMARQRRFLSHHHRHNNNNNNNNNNQQNQTQIGETCAAVAPQLNPVATTATGGTWMYWPNVPAVPPQLPPVMETQLPTMDRAGSASAMPRQQVVPDRRQGWKPEKNLRFLLQKVLKQSDVGNLGRIVLPKKEAETHLPELEARDGISLAMEDIGTSRVWNMRYRFWPNNKSRMYLLENTGDFVKTNGLQEGDFIVIYSDVKCGKYLIRGVKVRQPSGQKPEAPPSSAATKRQNKSQRNINNNSPSANVVVASPTSQTVK
The following text describes a protein:
Function:
Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Sequence:
MAYASVVSLAQTLGQLNTRIPGLFSDPKIQSLAASLDYFKAFLDDSSNSSYYHQENIKDLVGKFRDALNEAENIIELKICEIHQRGNEDLVPVVQKIELLREELVLSLETCTSHDHDTEPGEDHFETRVGSPSKPSFNANLENDVVGLDDDLEKVIERLLGYSSEREVVAITGMGGIGKTTLAKKAYDYPRVRSRFDVHAWVTVSREYGMRRLLLSLARCIPGMTADKLVEKTEDQLAESLYRKLKDRRYLIVIDDIWSTKVWDDVTRCFPDDDNGSRIILTSRLKDVAAYANPDSPLHEMGVLSLDDSWKLLSIKVFGVNDLCPFELEDIGKQIAERCGGLPLAILVVAGHLSKISMRRESWITVAKTVNSVVANDPDKCLGVLGMSYNYLSNHLKPCFLSIGAFPEDFEIKARTLIQVWVAEGFLKAERVESLEKVAEECLEDLISRNLIMIKKRRFNGEIRSCGMHDLLRDLSLREAQKEKFLHVTSARYVSNFLAQRNEGRGFSFLSNISLNDSSELSSHVTRSMFFWGELSISSPPHRQISLFASFKHIRVLAIISHMFPAFPAEITQLTHLRYLWIRSNGGLPASVSHLYNLQTLVFQQPELYYMHKTLVLPRDIWNMTQLRRLRLLSGNYLSKPKRSTTTDDVLGLSNLEELSHLCFASCTEEVFSCLPSIRKVSILDAASDDASEYLQNLVHLEKLETLKCVCYGQKRLTLSNWCASLTSVKRLILSGCLLLSQDMASLAALPNLEVLKLRDNEFEGCAWTLSDEDEFSQLKFLLLAEPRLLNWEAGSVNFPNLQKLVLRKCICLEEIPIDIGEICTLEMIELICCSSSAQNSANEIREEQESMGNSCLDIRVYVDDDEPSSLFDFWRAVLD
The following text describes a protein:
Function:
Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (By similarity). Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (By similarity).
Subcellular Localization:
Secreted.
Sequence:
GGGGGPAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWARYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC
The following text describes a protein:
Function:
Involved in the biosynthesis of phenolic sesquiterpenes natural products (Ref.2). Sesquiterpene synthase converting (2E,6E)-farnesyl diphosphate (FPP) to (E)-beta-caryophyllene and alpha-humulene.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MEFPASVASLSANTVGSNDVLRRSVAYHPNIWGDFFLAHTSEFMEISIAEKEEHEWLKEEIKKLLVQTEYDSILKLELIDSIQRLGVSYHFEKEIDRILRYVHQTYPIYETENKDLRMLALRFRLLRQHGFHVPCDVFSEFIDAEGNLMESIAYDIQGILSLYEASNYGVLGEEILDKALDSCSSHLESLITDTNDDRLSRQVKEALKIPISKTLTRLGARKFISMYKEDDSHNEKLLKFAMLDFNMVQRLHQNELSHLTSWWKELDFANKLPFARDRLVECYFWIMGVYFEPRHEIARKILTKVIYMASVLDDTYDVYGTLDELILFTSVVRRWDISGIDELPTYMRIYLRALFDVYVEMEEEMGKIGKSYAVEYAKEEMKRLAEVYFQEAQWFFSKYKPTMQEYMKVALLSSGYMMMTINSLAVIEDPITKKEFDWVVSEPPILKSSSIITRLMDDLAGYGSEDKYSAVHLYMNEKGVSEEEAFQELRKQVKNSWKNRNKECLEPRSASVPILTTVVNFTRVVVVLYTDEDAYGNSKNKTKDMIKSILVDPV
The following text describes a protein:
Function:
Component of the DNA topoisomerase VI complex involved in chromatin organization and progression of endoreduplication cycles. Binds to DNA. Required for endoreduplication beyond 8C.
Subcellular Localization:
Nucleus.
Sequence:
MVRASSSKKGGSKGGDKDDAESKQRKRLKTLALDNQLLSDSPAKSHSSLKPSKQVLKHHGTDIIRKSQRKNRFLFSFPGLLAPISAATIGDLDRLSTKNPVLYLNFPQGRMKLFGTILYPKNRYLTLQFSRGGKNVLCDDYFDNMIVFSESWWIGTKEENPEEARLDFPKELAQAENTEFDFQGGAGGAASVKKLASPEIGSQPTETDSPEVDNEDVLSEDGEFLDDKIQVTPPVQLTPPVQVTPVRQSQRNSGKKFNFAETSSEASSGESEGNTSDEDEKPLLEPESSTRSREESQDGNGITASASKLPEELPAKREKLKSKDSKLVQATLSNLFKKAEEKTAGTSKAKSSSKA
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), also called psiRNA (prokaryotic silencing) in this organism. This protein processes pre-crRNA into individual crRNA units, with an 8-nt 5'-repeat DNA tag that may help other proteins recognize the crRNA. Further processing occurs at their 3' termini in this organism. Generates a 5'-hydroxy and 2',3'-cyclic phosphodiester.
Sequence:
MRFLIRLVPEDKDRAFKVPYNHQYYLQGLIYNAIKSSNPKLATYLHEVKGPKLFTYSLFMAEKREHPKGLPYFLGYKKGFFYFSTCVPEIAEALVNGLLMNPEVRLWDERFYLHEIKVLREPKKFNGSTFVTLSPIAVTVVRKGKSYDVPPMEKEFYSIIKDDLQDKYVMAYGDKPPSEFEMEVLIAKPKRFRIKPGIYQTAWHLVFRAYGNDDLLKVGYEVGFGEKNSLGFGMVKVEGNKTTKEAEEQEKITFNSREELKTGV
The following text describes a protein:
Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).
Sequence:
MHNRSQGFFFSSCHPQNHVSYGCQSPSFIFCRCQSLNFVSRTCYPLSYFSYGNQTIGSISNSFRSLNYVSHSFQPISFMHSSFQPACSDFVGWQSPFLRRTC
The following text describes a protein:
Function:
Excises hypoxanthine, a deamination product of adenine, from double-stranded DNA. Acts on double-stranded DNA containing G/I, T/I, A/I and C/I base pairs, but not on single-stranded inosine-containing DNA. Also has minor xanthine DNA glycosylase activity. Lacks any detectable uracil-DNA glycosylase activity.
Sequence:
MKKQGFPPVIDENTEILILGSLPGDVSIRKHQYYGHPGNDFWRLLGSIIGEDLQSINYQNRLEALKRNKIGLWDVFKAGKREGNEDTKIKDEEINQFSILKDMAPNLKLVLFNGKKSGEYEPILRAMGYETKILLSSSGANRRSLKSRKSGWAEAFKR
The following text describes a protein:
Function:
Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MLSFKKYQDLISLLFYKHGLTCSTYPAIYICGVIIAFLFVCYPFSDLPFPANPAQYYTTPFHGHQVPLSRSHFNVHFNSSANLIDPDVPRWYFDAPVSYIQQIVVKSSLPSSLTSSSSSSSSSSSASSSSSSSSSSSSSSSSPSPSGLKSSLEVVFDLLEHIDSYRLNDSNRILSMTDLCFRVSEVTLSLSSSSSSSSSTGGGGDDTVVEDNDGDEDDGTFHLPQYNCLFLSPARLWDQDRDKFIDSLNKDLHEKYHNVISSAPIKNNNTSSSSSSSSSSSSSSSSLPTLRVDHMVHIHYQTHNYFVEYTPLIFAYVVLCLYLYFSVRKIEMVKSKWGLALSAMVTVVASLFMSVSLCMSVGLTPSLNGGEIFPYLVVIIGLENILVITKSVVSTPVHLEVKLRIALGLQKEGWYIFKNLLTEFFILAVGFLTFVPAIQVYWGFFIGVLLFQLSDLQRHHSALERQRRTSSSNNINNNTSNPTNNNNNTQCTYKDHHIQELASSPFSTLWYLYNRTTKSHNYNNNNNNINKGNKGNSCDDDDDDGYLYDSDGEKVSKRVRLLHVWARYRILQRAIMVFIIIWIALVVFKTTIMDDEHSSPSSSSSSSSSSSASSFVSNKDTANMEDSSFELPKLFYSSKLSSSNKNITYLQSNKRSFIDSPFRSSSSSSSSSSSSLLSSSSYMEHNDLELWKQLPYNHWENLYSCYNISLMGRSTLEFVLSTFLGLFSVVLLSCCLFMLYDCFCPRRYASWRSSWSSRHASADGRDQHNKYYKQIREARPLLLRGHRQEVECICTDGRLIASSCLGGEQQQKSPSLLPTTPSFDLSAIDNFFCDSKHSSKHEKRHQHQQHSRHRVVDATLASIIPDLTETIDTDFLRRARLNKSKNNNNNNCDYINNGTNADNNENINSININNNSSNTIKNDNIKINNNTNNTINNNSNRTSSIFRYPVNIDDDDDDDDCINHKHDEAASNDNILTSNTLISYISSDRNSRISCSIANNSSINNNNNNNNNNNNNNNNYSYKNNNNNDNNNNINNNNNNNIDSNTVVHSSSSGLNNVNNSDSKSNNNSNNNNNNNNNKSNCGFDFTQFQPYFDEQRAIYESGKQRQKIVTLRKRKRDKCLHARSQKKDEVVVDDEEFTLGSAIWCMAFKSNLIVLGCGSGDIEVFVGADGQKSFQCTHLWSTRAHQLTINCIQSDGALVLSAGQDFIVKVHKLADHSCLYTLIGHEACVTTLLVDKDDKLAITGSDDCSLRLWSLQTGSCLHKLIGHEGTITCVTYDNNHYNNSGEADDVIRLFSVALDDRLCIWDTRRGHLLHCIQMDPGCSNTLAVLSHQLILTGGLGCLYLWDVDKEVVLRRMPLSEEPSSVFIRQLFVCQAGHIVCDYGSQLRVIRLNFVLEKDE
The following text describes a protein:
Function:
Odorant receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAWENQTFNSDFILLGIFNHSPPHTFLFFLVLGIFLVAFMGNSVMVLLIYLDTQLHTPMYFLLSQLSLMDLMLICTTVPKMAFNYLSGSKSISMAGCVTQIFFYISLSGSECFLLAVMAYDRYIAICHPLRYTNLMNPKICGLMATFSWILGSTDGIIDAVATFSFSFCGSREIAHFFCEFPSLLILSCNDTSIFEEVIFICCIVMLVFPVAIIIASYARVILAVIHMGSGEGRCKAFTTCSSHLMVVGMYYGAALFMYIRPTSDHSPTQDKMVSVFYTILTPMLNPLIYSLRNKEVTRAFMKILGKGKSESELPHKLYVLLFAKFFFLISIFFYDVKILALIMYIA
The following text describes a protein:
Function:
Monitors proton H(+) homeostasis in chloroplasts to manipulate luminal acidification levels appropriately to balance photoprotection and photochemical processes. Required during acclimation response to fluctuating light (e.g. photosynthetic activity optimization) by controlling non-photochemical quenching (NPQ); acts independently from DLDG1.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Plastid, chloroplast membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MASSSTFLELTPFQWNQPLPYTQRPHHRTVLLYSKPQRRSNSIRLQISVKYKQSTSSSDPDLRSNFNPFEQIAIQVKKALDSLKKPAIAAVLLGLLLFYDPNSALAASGGRIGGNSFSSRSRSSSSSSSQSYSVPRTSNPSFSYSARTAPYYGPSPFGGGFVGPAVGFGFGGFSSFSLILVGFAAFVLVSGFLSDRSQDDSILTDTQKTSVIKLQVGLLGLGRTLQQDFNRLAESSDTSTPEGLSYVLTEATLALLRHPDYCISCYSSVDVKPSIEKGEKRFNQLSIEERGKFDEETLVNVNSIKRQSSKIRKASGFSNEYIVVTILMAAEGIHKLPPINGTTDLKEALLKLGSIPRNKIMAVEVLWTPQNEADALSERELLEDYPLLRPL
The following text describes a protein:
Function:
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
Sequence:
MSVVTVQLGQCGNQVGGALFDVLAGEALSASRKEEPEAETFFRRGKGGTQWVARAVLVDMEPKALASTVRSARASSGGVWGFDEGRLFSRESGSGNNWARGFHTHGPACRDDILNLVRKEVEECDRFGGFLTLQSVAGGTGSGLGAYAAGCLRDEYPASPLLGHCVWPHESGEVIVQSYNAMLTLPKLAQAADGVILVENEALTATCRRLLNISRPSYTDLNLVAGRALACVLLPAQWRSEADSVGVGGARFRPLSDLVSAVCAHPHYPLLSLRALPQIPPASVDFTTFTWPSLVRQLRQMASSGAPLESAVDWAAASGAPSSPPPAGTFRSVNKSVSSLLVLRGKGASGVDVSSFASPTLYPSWAVDPLTVISSPTQFGKYEMATGLLSNCQTLVSPIERMLGRAYEMSHAGAYLHQYYQHGMSEASFEAAFASVEETLCHYRSL
The following text describes a protein:
Function:
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
Subcellular Localization:
Host nucleus. Host cytoplasm.
Sequence:
MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSERGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFETSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMNKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKRKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTEISFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKIRTQIPAEMLASIDLKYFNDSTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRHTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVNRFYRTCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTHSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVNHKDIESVNNAVIMPAHGPAKNMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFTEIMKICSTIEELRRQK
The following text describes a protein:
Function:
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
Sequence:
MAQAQATAQQRTELLARQLLAAEQANGLVMAPTAGHQHASQVEIPTFSIALPEKLTPDGPWSVYRSATSPFQLVSTYPPPADHVRTLHDNLEYAASKFPHMPYLGWRKRDDKGRLGAYTWMTYAQASDVRTALGSGLMQLGLQPKSAVGIYSVNCKEWLLYDYALHAYGMVSVPLYDTLGPDAVEFIANHAELAAVGVSAAVLPTMLTVLHRCPTVRLLVVWGASGPLPDPPAGASHCRLMTLEAVEGLGRRHPRAHLPPKPSDIATLCYTSGTTGTPKGAVLTHGNLISNAAGTATLLTESSPGDRHLSYLPLAHIYERVNIVLLTYLGAAVGFYSGNVQELLEDVTVLKPQIFASVPRLWNRIYDRVMLAVQTGSPLARGLFERAYAHKRACLAKGDPVGGRWGRLYDRLVFSKIRAKLGGELKYMISGASPISEEVMSFLRICFGAVVLEGYGMTEAACTISTTRAEDLTTGHVGAPNPAVEIKLVDIPEMGYTARDSPYPRGEICVRGPSVFAGYYKDEAQTRDVLDGDGWLHTGDVGAWLEGGRLKIIDRKKNIFKLAQGEYIAPEKIENTYTRSPMVLQVFVYGDSLRSQLVAVVVPDPEVLVPWAKERGIAGSLPELCANPHVRDAVLKSMQEQAREAQLRGFEQVHTIHLFPEPFSVENDMLTPTFKLKRPQAKARFQEELDAMYAAMPATH
The following text describes a protein:
Function:
S antigens are soluble heat-stable proteins present in the sera of some infected individuals.
Subcellular Localization:
Parasitophorous vacuole. Note=Localizes to the cell periphery in early schizonts and then to the parasitophorous vacuole in late schizonts. Following schizont rupture, the S-antigen is released in host sera.
Sequence:
MNRILSVTLCLFFIYLYIYKTYGKVKNTDEGLSNIYGAKYYLRSGLFNEKNGKGQKYEDLEEEKEGENDDEEDSNSEESNNDEENELIKGQEGVEQETHGSEDEVSNGREDKVSNGGEDEVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGREDKVSNGGEDEVSNGREDKVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGREDEVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGREDKVSNGREDEVSNGREDKVSNGGEDEVSNGREDKVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGREDKVSNGREDKVSNGGEDEVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGGEDEVSNGREDKVSNGREDEVSNGREDKGGAGTDGELSHNSESHTKNKKSKNSIINMLIGM
The following text describes a protein:
Function:
Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
Subcellular Localization:
Nucleus.
Sequence:
MSRDAITNAAGTVESTLLHQVFIQSLLSRRVVSEAIALELYKRAVTAVRAYDRQFNPPYAISGHGVASFVTDVSTLLHSVSLEVIRTIDQRSDRAFFVLRNLDASEVASFATDLNSMEVEYLRNLIESIVVSYPANSLAIGQARDVINDSPLTQHKMTKSHAESLLDALVSRGWLYKSKRTRFSLGVRALAELETYLKNEFDQYVKSCAQCRRVVTEGLACSNVGCDCHIHNTCYARNIQQLANPVCPSCSSSFRDLAPKPVGEKAVSIMEDNFKGGRKRKGKGKNVGDMDDEGEEEEGGSSEAEDELDERRESQSQTQNQGSIRRSYVPETQYDEEPSTGSAGPSKRIRRG
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTTPRVPTTFTRKVAGGVKTTTTGSSLPTNNTSTTTTTTTTAAKKLPNGCKISIKNSNLLTSTGLTDLDDIIGGGIPIGSILMIEEDINSSYYMFLLKYFLAEGVLQQQGVFFSSLIGIDPFEILNKLPARITKEEEIEADKNDTTNNINTNINTNNNNKQPTDELKIAWRYQQYVSNELSKQQQQQSASTIMNQTFCHSYDFTRKMNVQSMNPELIHTLSHDAQSQAEGTSPYRNLFLEIQNLVYKYNKEAAMNPDQTRVLRLCIQSFSSPLWSNDEEGVIEFLHALKGLLRSSVATCVISVPTYIYSGAFVKKIAHLCDTVVSINSFSGLGGETPEQFAEYLGLFNIRKIARLNTLSLSFHPDMLTFVFKMKRRKMCIETIHLPPESSRAGDSKPDNNDSNKNKSDQNNIVSKMKSGSGLLCGGGGGGSSNNNPLDF
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTVKRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLDSELSLKLTSIGLDLSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAYLYRAAEDIKKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTAVATHDDDIIKFTKQLVAEHRIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTDWFSYFMRRIAERPANAAFVLKGILKK
The following text describes a protein:
Function:
Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex. Involved in the control of ciliogenesis and ciliary length.
Subcellular Localization:
Cell projection, kinocilium. Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MSGTSARSSHLSQPVVKSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQLQSGGNYVAGGQEAFKKLNYLDIGEMKKRPMEVINTEVKPVMHSRINVSARFRKPLQEPCTIFLIANGDLISPASRLLIPRKTLNQWDHVLQMVTEKITLRTGAVHRLYTLEGKPVESGAELENGQFYVAVGRDKFKKLPYSGLLFDKSTMRRSYGQKASSLPPIVGSRKSKGSGNDRQSKSTVGSSDNTSPQPPKRKGRKEEVSLEKPKKGKQNVKLKKSPQTSPNSDEGVFKAGAERSETRGAAEVQEDEDTQVEIPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGEVEEGGDLEATEASEEVEEVPDHREEPAGPTRGNGGTDEENGEELDQVTTELQEAVDEDVKSQGAGTGQNEADLDHQRPPRPEVKITSPQ
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MAHRLRGTKPGQIVHSQVDKASSKSTTSAKPQRPKPAEVPVEEDRALYTNDNGSDGIVLLVDIREWGGDRVKLGELHRYLCRLGVRHRTASLQCGDYSWVWKCGGVEHVLPVLVERKRADDLAWSLKDGRYFTQKDRMLDFRRRFSPYSLHCSLKYIVECTPEQYMVRCGDGCRGVARCGNPTVEQVNNVLEELDASDDFDLVRTENIEGTVEFLATVTAELHQR
The following text describes a protein:
Function:
Plastidic transporter involved in the biosynthesis of aliphatic glucosinolates by translocating the biosynthetic intermediates of Met-derived glucosinolates across chloroplast membranes. Transports short chain (C2) alpha-keto acids, such as 4-methylsulfanyl-2-oxobutanoic acid, from the cytosol to the chloroplast where they are subjected to chain elongation cycles. Also functions in the transport of chain-elongated (C3 to C8) Met derivatives from the chloroplast to the cytosol. Does not seem to be involved in the transport of indole-derived glucosinolates.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MGVISPTETLFLKSQHRLLQPRNYSYALAFHSTRRVANFPRNSFSSLGSCSVDFPLRSNPISQNSKSIHPWRRYVSESDSNELYHKKVSSIMETLKQAYSFIPHGILLSTILALVYPPSFTWFKPRYFVPGLGFMMFAVGINSNERDFLEALKRPDAIFAGYIGQYLIKPLLGYIFGVIAVSLFNLPTSIGAGIMLVSCVSGAQLSNYTTFLTDPSLAALSIVMTSISTATAVLVTPMLSLLLIGKKLPVDVFGMISSILQVVITPIAAGLLLNRLFPRLSNAIKPFLPALTVIDMSCCIGAPLALNIDSILSPFGATILFLVITFHLLAFVAGYFFTGFFFSKAPDVKALQRTISYETGMQSSLLALALATKFFQDPLVGVPPAISTVVMSLMGVSLVTIWKNRKE