lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane.
Sequence:
MAAEVPSQPQAALEAPLPEPEQPSLSELDADTTVQSAIRFLQDPRVRCSPVESQIRFLKGKGVSDGQIKYALAKVGRTVTAEKIASVRAPLANAAPTGATATAYATPLSAQLKTARQNAPVAMTPGPQYTQMLFPHSPPPPQVERQTKTVDWRDVVIGAGAAMLAGFSAYKLFNRYSPYEFRRKSDKKPRLYRGSSSRPRPANIASSGSETDASSTPQRGCVLPLPPPPPMAAAAEPSVSAASPAALTEEVKRLQTELDEAKEALANERKKCADLAVSAAKIRADKQQLSRANDRLTQQIDGLKKDIESLEGKKSSAVGEATQTAAEGAVAAVPAPPSTYFPSVTTEGEQARNSAEVTSVTSASAPNSDVMPVLPVVPSPEATAIAAAAPAMPDPITEAAQAAPASVAAVAPAPESPPAVFAASTPYVDAAAPVATVTEVAAPLLSIGSAEPPKAGDGTPMSTG
The following text describes a protein:
Function:
Putative androgen-specific receptor.
Subcellular Localization:
Cytoplasm.
Sequence:
MPERELWPAGTGSEPVTRVGSCDSMMSSTSTRSGSSDSSYDFLSTEEKECLLFLEETIGSLDTEADSGLSTDESEPATTPRGFRALPITQPTPRGGPEETITQQGRTPRTVTESSSSHPPEPQGLGLRSGSYSLPRNIHIARSQNFRKSTTQASSHNPGEPGRLAPEPEKEQVSQSSQPRQAPASPQEAALDLDVVLIPPPEAFRDTQPEQCREASLPEGPGQQGHTPQLHTPSSSQEREQTPSEAMSQKAKETVSTRYTQPQPPPAGLPQNARAEDAPLSSGEDPNSRLAPLTTPKPRKLPPNIVLKSSRSSFHSDPQHWLSRHTEAAPGDSGLISCSLQEQRKARKEALEKLGLPQDQDEPGLHLSKPTSSIRPKETRAQHLSPAPGLAQPAAPAQASAAIPAAGKALAQAPAPAPGPAQGPLPMKSPAPGNVAASKSMPISIPKAPRANSALTPPKPESGLTLQESNTPGLRQMNFKSNTLERSGVGLSSYLSTEKDASPKTSTSLGKGSFLDKISPSVLRNSRPRPASLGTGKDFAGIQVGKLADLEQEQSSKRLSYQGQSRDKLPRPPCVSVKISPKGVPNEHRREALKKLGLLKE
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm, cytosol. Rough endoplasmic reticulum.
Sequence:
MAGEKVEKPDTKEKKPEAKKVDAGGKVKKGNLKAKKPKKGKPHCSRNPVLVRGIGRYSRSAMYSRKAMYKRKYSAAKSKVEKKKKEKVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHRGKRVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEVFDTEKEKYEITEQRKIDQKAVDSQILPKIKAIPQLQGYLRSVFALTNGIYPHKLVF
The following text describes a protein:
Function:
Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MPGISDAETIRILVSTDNHVGYNERDPIRGDDSWKSFHEVMCLAKERDVDMVLLAGDLFHENKPSRKSMYQVMRSIRMNCLGDKPCELEMLSDASENFQGAFNHVNYEDLDINVAIPIFSIHGNHDDPSGEGHLAALDLLQVSGLLNYYGRTPESDNIHIKPVLLQKGRTKLALYGMSNVRDERLFRTFRDGKVKFYQPSIQKNDWFNLMCVHQNHHAYTETGYLPENFLPDFLDLVIWGHEHECLINPRLNPETKFHVMQPGSSVATSLVPGEAVPKHVAILSITGREFKCEPIRLKTVRPFAMREIVLSEEKGAQKLARKENNRTEVTRFLISIVEELIEEAQAEWLEMQDEADDDEEREVPLPLVRLRVEISTPEGGSYDCENPQRFSNRFVGKVANVNDVVQFYRKKKNTTTRKKDDEIDEAAMSQLSTLDTVKVEQLVREFLAAQSLTILPQNSFGDAVAQFIDKDDKHAMEMFVNESLESQVKHLMSLDREGDEMDDEELARSSIQKAMEKYRTQMEEMFSRGVKKRSTRGKKRFKPKPDGWDTEFDGEWEDQPGALIHSDNEVGDPNEEEAAEDGTEPQTASSTRGRGRGRGGRAAAATTSRTTAKASAVKKSTSATTTRSRKQQVISDEEDDDVVMLDDDEEDAAPQALSNIEEDEDDDDDSQALFVKQPTTRTRKPASSSVATRPHRSGRSAASPAPSSATISGTATGRTSGRARQRQTTLNFVGSQSSTRSRAAEPSRPASKTSRSTRAASVASEDIDDDSDAFEPMQTSRRRR
The following text describes a protein:
Function:
Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.
Sequence:
MRRAAGDRPVAGPMRELLQGPGVENPPASSGPYLQRQAQRESNARSYPRRIPFAFKKAEGVYLTSVEGKQYIDCLAGAGALPLGHNHPVAIQAIQTVIRGKFPLLTLDLPTPLKDRFVDELFACLPAEFARNARIQFCSPAGTDAVEAALKLVKTATARRGILSFQGAYHGMSHGSLSLTGNLAAKVVPNLMPEVQFLPYPYELRCPFGLGGEVGYRTGLHYIENLLKDPEGGVPSPAGIILEVVQGEGGVIPAPDEWLRGLRRITQEQQIPLIVDEIQTGFGRTGKLFAFEHSGIVPDVLLLSKAIGGGLPLAVVVYRESLDRWQPGAHAGTFRGNQLAMATGLATLRHILEHRLWEHAQVMGERLLTHLHQIRSSWIGEVRGRGLMLGVEIVDPTGEPDYRGIAPHAGAMARRIQAECLERGVIVEVGGRDGSVVRFLPPLIVTDSQIDTIAEVFHDAVHAATRITSTAPDSRIALPTAAL
The following text describes a protein:
Function:
May act at junctions between the membrane and the cytoskeleton; Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.
Subcellular Localization:
Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Photoreceptor inner segment.
Sequence:
MTSRLRALGGRINNIRTSELPKEKTRSEVVCSIRFLDGLVQTFKVNKQDTGQVLLDMAYNYLGVTEKEYFGLQHGDDSLDSPRWLEASKPIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDHDSSIHPPGYLSDSQFIPDQNDDFLTKVESLHEQHSGLKQSEAESCFINIARTLDFYGVELHSGRDLHNLDLMIGIASAGIAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQTESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNPKKRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSMSPKDSDSEVSQNRSPHRESISENNAAHGCLTQKSSSSASPSSNAPGSCSPDGVDQQFLEDFHRVTKGGSTEDSSQYYCDKNDGDGYLVLIRITPDEEGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHTRELVLVIRRKAVHSFADIKSEDELNQLFPEAIFPMCPEGGDTLEGSMEQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAAHLVNKYIAAQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPNPPDVMEHGSFHIRCRSEDCTIAYVFREMLVTNTETGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDGEPVVVHCSAGIGRTGVLVTMETAMCLIERNLPVYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS
The following text describes a protein:
Function:
With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.
Sequence:
MHTVWKGALSLGLLNIGIKLYSAVEENDIKFLSLHKECLTPIKYKKFAPDCTGEEIDDKDIVKAYEYAPHKYIIMDEKELAELQKAHEPRSIRIISFIQNNEIDSVLYDRSYFIGPTSGHEKSYLLLKEALERTNKLGLIHISIRKKQHLAIIRNFEDGLILQTIHYPNEIRDITNTPNLPSNENYPIQKQELTAAINLIHHLTNPFEQEMYTDEYKEALTELIENKIEQQEKTETISPTPNIINIMETLQASIEQAKIKRENKAEKEAK
The following text describes a protein:
Function:
Functions in the early stages of organ development by regulating cell division rate. Is probably involved in the regulation of a number of cell-cycle genes. May act as regulator of brassinosteroid (BR) signaling and cell-cycle controlling organ growth.
Miscellaneous:
MISCELLANEOUS: Xiao means small in Chinese.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MPPPPRLLFLLVMLLVVAAPGAPVFGANAPPEVKAEIDALLMFRSGLRDPYAAMSGWNASSPSAPCSWRGVACAAGTGRVVELALPKLRLSGAISPALSSLVYLEKLSLRSNSLSGTIPASLSRISSLRAVYLQYNSLSGPIPQSFLANLTNLQTFDVSGNLLSGPVPVSFPPSLKYLDLSSNAFSGTIPANVSASATSLQFLNLSFNRLRGTVPASLGTLQDLHYLWLDGNLLEGTIPSALSNCSALLHLSLQGNALRGILPPAVAAIPSLQILSVSRNRLTGAIPAAAFGGVGNSSLRIVQVGGNAFSQVDVPVSLGKDLQVVDLRANKLAGPFPSWLAGAGGLTVLDLSGNAFTGEVPPAVGQLTALQELRLGGNAFTGTVPAEIGRCGALQVLDLEDNRFSGEVPAALGGLRRLREVYLGGNSFSGQIPASLGNLSWLEALSTPGNRLTGDLPSELFVLGNLTFLDLSDNKLAGEIPPSIGNLAALQSLNLSGNSFSGRIPSNIGNLLNLRVLDLSGQKNLSGNLPAELFGLPQLQYVSLAGNSFSGDVPEGFSSLWSLRHLNLSVNSFTGSMPATYGYLPSLQVLSASHNRICGELPVELANCSNLTVLDLRSNQLTGPIPGDFARLGELEELDLSHNQLSRKIPPEISNCSSLVTLKLDDNHLGGEIPASLSNLSKLQTLDLSSNNLTGSIPASLAQIPGMLSLNVSQNELSGEIPAMLGSRFGTPSVFASNPNLCGPPLENECSAYRQHRRRQRLQRLALLIGVVAATVLLLVLFCCCCVYSLLRWRRRFIEKRDGVKKRRRSPGRGSGSSGTSTDSVSQPKLIMFNSRITYADTVEATRQFDEENVLSRGRHGLVFKACYNDGTVLAILRLPSTSSDGAVVIEEGSFRKEAESLGKVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVVHGDVKPQNILFDADFEPHLSDFGLEPMVVTAGAAAAAAAASTSATTTVGSLGYVAPDAAAAGQATREGDVYSFGIVLLELLTGRRPGMFAGEDEDIVKWVKRQLQRGAVAELLEPGLLELDPESSEWEEFLLGIKVGLLCTAPDPLDRPAMGDVVFMLEGCRVGPDIPSSADPTSQPSPA
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).
Sequence:
MAKFKVHIGKIPRSITARELVDVLERAVGKGTVTVVDIKTDHRTCESKGFGFVTFNTEKAAERAALLGENGHLVLLNSRLQVSIADRQKDLCSMLSETLASWQWSSRSNVTSDFNFDNHKVHFVFDVTNNLEKRHYKMESNFEELDAVKIVAVRGASTRALLLQLRTPPYLYVQRASKCRSRETILDMIIGTPSLDPHYVHTEEEEGLWVRTVDYTPKRSIGQCLSYLLKISNTKTGDDMNDLFKKLAEFHLAAYPPVIQQISLQKGAPFASSQVLVPIVDAPPEKKVNFELMFQVNQLLQTSKLIGETLDSRFYHLLQPDVTPHEQAKLVLERLGKRVGPCWDPVKEIQEELGNMKETLSSPRSVSIKLASGMTWVRRVLVTPTKVYCTGPEVDTSNRVTRQFASHSDRFMRMSFVDENLEPLSSVALSVPRRGGAQDGVDAERSLLYNRVLKTLKEGIVIGDHKFEFLAFSSSQLREHSVWMFASYAQLTATMIRAWMGDFLTIRNVAKCAARMGQCFSSSKPTLEVPEQEVEQIPDIEREDEFGMSKYCFSDGIGKISKEFAKEVAKRLQMEVVPSAFQIRYGGYKGVVAVDPHSDFKISLRPSMRKFASKHVGLDILASSRFLPSYLNRQIILLLSTLGIEDSVFEQMQHRMVSELNDMLKDGDVARDMLQINHAGEMHTRLIDMLAAGYQPQTEPFVKMLLEAFRASQLVDLRKRSRILEPKGRVLMGCLDETKSLSYGEIFLQVTPALGRRKGLRDGLETFDSYPIGSAANQNIAYVVTGWVIVAKNPCLHPGDIRKLKAVDGPGLRHMVDCLVFPQKGHRPHPNECSGSDLDGDLYFVSWDEDLIPLNTDEPMDYTSPGAMTLDHHVTIEEIQEFFVKYMVTDSLGVISNAHVVNADIEPAMARSTACQELAKLVSLAVDFPKTGVPAIIPQNLRPTKYPDFMEKGDKETYKSERVLGKLFRQVKDASLEKLPCEIPREDIERAFDPVMVITGYEEFIDMAKFHKNEYDRKLIGLMNQYGIETEAEAVSGYMLNLARQYVKRREDVVERIRDAVRSLINEARQRFDENADDMVDDDIYAKASAWYHVTYHPEHIKVSATGRREVHLISFPWVIYNVLLQIKKAGGRPC
The following text describes a protein:
Function:
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGKLIRMGAQERRSLWPKRLHWSRPLFLLGMLIIGSTYQYLTSPQGLPTLWAAVSSQHPVKVASRDLSNKEMMMVSSETSKSSSEMEVEAWAPEATAGRDGTPPGIARKNTPSTPRGTASITPAIPNNYSPTPTGTGKVKEDTSATPSGVLNHYTQSRPMVNSYTRLTARGEVKSSRPTQSRGKEEKYSPSPLGRMVNSYAPSTLMTMPRSHGITPRTTVKDREIMATKKMLATNPSKRLVEKTTPTPLKGITDNTPTFLLSDLETDTLTSPRNVVEKKTLTTPRRVDSNSSTNHQGLVGKNNLTTPQGMVLEHTAAVSEGQVTISTMTRSSPTETKASTDAWKVRNPLPRTSAPIIRISSATFRGLLKNPSKAPSTPAAPRVRANPTIQVRHCLVVEPAPVAPTAPSPSWTTAVIPGIPSPSGQPDLYPKAEYPRDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDITFYIFDLMMLILFFLDSLIAWWESVLLLLAYAFYVFTMKWNQQLELWVKEQLNKRPVAKVMALGDLSKPGDGTVVVDEQQDNKKLKLSSMLTRGSSSASLHNSTIRSTIYQLMLHSLDPLGEARPSKDKEEETLIPEAKATPQAKAESKPEEEPAKLPEVTVTPAPAPDVKGDQEEDPGSQGVGAEAENTGERTGGEAEAPAEGENGERSGGDAALGGESEGKAENESEGDIPAERRGDDEDEGEIQAEGGEVKGDEDEGEIQAGEGGEVEGDEDEGEIQAGEGGEVEGDEDEGEIQAGEAGEVEGDEDEGEIQAGEGGEVEGDEDEGEIQAGEAGEVEGDEDEGEIQAGEGGEVKGDEGEIQAGEAGEVEGEDGEVEGGEDEGEIQAGEGGEGETGEQELNAEIQGEAKDDEEGVDGEGGGDGGDSEDEEEEDEEEEDEEEEEEEEEEEEEENEQPLSLEWPETRRKQAIYLFLLPIVFPLWLTVPDVRRLEAKKFFVITFLGSILWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWMLFSLINGLQPVAVSSNGLFCAIVLLFLMLLFVISSIALCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV
The following text describes a protein:
Function:
UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.
Sequence:
MSNDQLKSKLREFFDRQPDQSEKAHQDSKIFEVLYSQFLENQHCIDWNSWKFLEEKHQVTLKDLEPFDKSRFNILNKLAVIKLNGGLGTTMGCSKAKSLVEVREGYTFMDLAVLEHQKMCEAHNVDTPLYLMNSFYTDEDTKKYLAEKGYSNVKTFVQSKCPRLDAETKLPIEDENEDWGDDAWCPPGHGNIFQSLQNSGVLDQLLADGREIIFVSNIDNTGANTDLQIVQLMLDKNVDYIMECTPKTQVDVKGGTLIDIGGRMMHLEMPQVPAENLPDFCSTKVFKIFNTNNIYVNLKAVKKLLPDIKSEIIVNKKTIRSREVLQLEFSIGGCIKNFDNALCVHVERKRFRPVKNLGDLLSLRSTLCDLDHSTFKVHHNHELGAPPVISLDPSIYNSVEVVDLKFPHPLVMDNCSEFAVVGDVTFGKNVKLSGKVTVNGKTESPGVVPDGTVLKDQEYIAE
The following text describes a protein:
Function:
DNA helicase that acts as an essential component of the spindle assembly checkpoint (By similarity). Probable chromatin remodeling factor that regulate homologous recombination (HR) and non-homologous recombination (NHR).
Subcellular Localization:
Nucleus.
Sequence:
MAENTASHRRKPRSLNDRHYSILQDLSAPPRQPPSSSHGEDEETKKSMIKLAGRRRLCKALPKEDEADGYDDPDLVDFYSPVKGETSLDSAGIGNKFTSWDESKEANTELAGEPNFSIITDFCSPSPQLKQKEEMQGDGGRNEIMGILDDLTSKLGTMSIQKKKDSQSNDFDACGVKSQVDKFDFEDAKSSFSLLSDLSKSSPDVVTTYNAGVNSIKDKQGKSGFAIREEQTSKEFSREWEERISNVGKQNSYSGRHFDDNSEDNRQGYNLDRGKSQCKEVDQSMKTTRHIEVSEKIRTVGRSNAAKLRDLDEDDDDDDCLILSGKKAAEMKINKPARSYNAKRHGYDERSLEDEGSITLTGLNLSYTLPGKIATMLYPHQREGLNWLWSLHTQGKGGILGDDMGLGKTMQICSFLAGLFHSKLIKRALVVAPKTLLPHWMKELATVGLSQMTREYYGTSTKAREYDLHHILQGKGILLTTYDIVRNNTKALQGDDHYTDEDDEDGNKWDYMILDEGHLIKNPNTQRAKSLLEIPSSHRIIISGTPIQNNLKELWALFNFSCPGLLGDKNWFKQNYEHYILRGTDKNATDREQRIGSTVAKNLREHIQPFFLRRLKSEVFGDDGATSKLSKKDEIVVWLRLTACQRQLYEAFLNSEIVLSAFDGSPLAALTILKKICDHPLLLTKRAAEDVLEGMDSTLTQEEAGVAERLAMHIADNVDTDDFQTKNDSISCKLSFIMSLLENLIPEGHRVLIFSQTRKMLNLIQDSLTSNGYSFLRIDGTTKAPDRLKTVEEFQEGHVAPIFLLTSQVGGLGLTLTKADRVIVVDPAWNPSTDNQSVDRAYRIGQTKDVIVYRLMTSATVEEKIYRKQVYKGGLFKTATEHKEQIRYFSQQDLRELFSLPKGGFDVSPTQQQLYEEHYNQIKLDEKLESHVKFLETLGIAGVSHHSLLFSKTAPIQAIQKDEEEQIRRETALLLGRASASISQDTVINGADYAFKPKDVNLDKRINISPVDDKELSESVIKARLNRLTMLLQNKGTVSRLPDGGAKIQKQIAELTRELKDMKAAERINMPQVIDLEEDISRKMQKGLNL
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MLDGHVLLGWLSSCALLGLLACTPRPSAAYFGLTGNEPLTILPLTSEMEEAAVKAHYKVCDRLKLEKKQRRMCRRDPGVAETLMEAISMSALECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHAMAKACSAGRMERCTCDEAPDLENREAWQWGGCGDNLKYSNKFVKEFLGRKPNKDLRARVDFHNNLVGMKVIKAGVETTCKCHGVSGSCTVRTCWRQLSPFHEIGKQLKQKYETSLKVGSTTNEATGEGDISPPKKSIPGHSDQIPRTTDLVYIDDSPSFCLMSRYSPGTSGRKCYKDKNCDSICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTCKD
The following text describes a protein:
Function:
This enzyme has both RNase and DNase activity. It degrades single-stranded DNA and RNA.
Miscellaneous:
MISCELLANEOUS: The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MSSNLIKSFGLIAIGAISGVTFTHFYYKGYQGSDVPDLTPRYTKFDSAGRALESIYDFNATKFFQYGIPGPVADQRVNHGYMSVFDRRTRNPFYTAETITQESLNQRKGNRRYSEFVPDDNIPEMFQAKLGDYRGSGYDRGHQVPAADCKFSQEAMNETFYLSNMCPQVGDGFNRNYWAYFEDWCRRLTSKYGSVTIMTGPLYLPKKNERGQWEVQYRVIGNPPNVAVPTHFFKVIIAEKSGEPTSSPSVAAFVLPNKPIADNFPLKNFAVPVEVVERASGLEILSNVPKGNRKQLCSEVVCQLNVKEFVESVKQKQKNQGK
The following text describes a protein:
Function:
Part of the ABC transporter complex OppABCD involved in the uptake of oligopeptides. Responsible for the translocation of the substrate across the membrane. Glutathione (GSH) uptake by mycobacteria through the OppABCD system contributes to the depletion of the GSH pool in infected macrophages, which impairs the ability of the macrophage to detoxify methylglyoxal (MG) and contributes to enhanced production of inflammatory cytokines.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTRYLARRLLNYLVLLALASFLTYCLTSLAFSPLESLMQRSPRPPQAVIDAKAHDLGLDRPILARYANWVSHAVRGDFGTTITGQPVGTELGRRIGVSLRLLVVGSVFGTVAGVVIGAWGAIRQYRLSDRVMTTLALLVLSTPTFVVANLLILGALRVNWAVGIQLFDYTGETSPGVAGGVWDRLGDRLQHLILPSLTLALAAAAGFSRYQRNAMLDVLGQDFIRTARAKGLTRRRALLKHGLRTALIPMATLFAYGVAGLVTGAVFVEKIFGWHGMGEWMVRGISTQDTNIVAAITVFSGAVVLLAGLLSDVIYAALDPRVRVS
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization.
Subcellular Localization:
Cytoplasm.
Sequence:
MGSNLPAQPNLRLTTDGLYKRDVFRFPDPFAVATVGGEQTHTTSVIKKTLNPYWNEMFDLRVNEDSILAIQIFDQKKFKKKDQGFLGVINVRIGDVIDLQMGGDEMLTRDLKKSNDNLVVHGKLIINLSTNLSTPNTNQANGLHRSHVQSSTSSGLVPQVAPSSSHPAASGTAPVDPSASNPSLNPQRVPSTTRPSSTAAPASAAGAAVSNSHGSRTNLSSFEDSQGRLPAGWERREDNLGRTYYVDHNTRTTTWTRPSSNYNEHAQRSQREANMQLERRAHQSRMLPEDRTGANSPNLPESSQQAHTPPAGGSANAVSMMATGATTAGTGELPPGWEQRTTPEGRPYFVDHNTRTTTWVDPRRQQYIRMYGQNANGTNTTIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQGVPQYKRDFRRKLIYFRSQPALRIMSGQCHVKVRRNNIFEDSYAEIMRQSASDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGVNPEHLNYFKFIGRVVGLAIFHRRFLDSFFIGAFYKMMLRKKVSLQDMEGVDEDLHRNLTWTLDNDIEGVLELTFSVDDEKFGERRTIDLKPGGRDIPVTNENKAEYVELVTEWKIVKRVEEQFNAFMSGFNELIPADLVNVFDERELELLIGGIADIDVDDWKKHTDYRGYQESDEVIQNFWKIVRSWDAEQKSRLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKSGDPAALPKSHTCFNRLDLPPYKSYETLEHKMSIAVEETLGFGQE
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MSQLSQKSQIKLQKGQIVGLLQDYRELNKQIHETSEEIIMSQNPKMLTNYLDKNDSYFQDVRTPSTFAKDCETLRTITETAVTQSSNVNLGPRPFTFNNVRQKMMAMFPDGRYLDWDAIGEWALRRSLTAPICTPFLFGLEEFEVKKRERAPTQRKGKDVIEEEQEVKNKDMSQAIANQLLARARKLCDRLKKDGDMPVSKVIATKAGFSESVENAFELSHLVRDGKVGLHTENSKVVATANVQQSQANDRRKQCILHLRDIDYQKLLQLEQ
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively. PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MARPRPAPRAARDPRVPSGAEVRGRRPGVRAERLRRAGPSGAAGAERSAAEGSASGAGAPASGGDADARPAPRRRGRPGMEEECRVLSIQSHVVRGYVGNRAATFPLQVLGFEIDAVNSVQFSNHTGYTHWKGQVLNSDELHELYEGLKLNNVNKYDYVLTGYTRDKSFLAMVVDIVRELKQQNPRLVYVCDPVMGDKWNGEGSMYVPEDLLPVYKEKVVPVADIITPNQFEAELLSGRKIHSQEEALAVMDVLHSMGPDTVVITSSDLPSPRGNDYLIALGSQRMRSPDGSVVTERIRMEMRRVDAVFVGTGDLFAAMLLAWTHKHPNNLKVACEKTVSAMHHVLQRTIKCAKAQAGKGLKPNPAQLELRMVQSKKDIENPEIVVQATVL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MAFRGGRGGGRGRGGGRSQGLEYRHSVDKPWEFFPEKELPPLPSTTQQDLTLMRKKVQLTNYWKHSPYYITDENPKSVVDGLQLYSDVVEAKKKENREKFESYLKLNESNFPSELIQGTKQKITTVKLRWDRNIDHKMNLFEKLELSEKKKDDTGNDSEEEEQADNQLEEENEESSEDGDYLQNVDFDDDDDDQVIEDDEMENIYED
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MDGIDGTDHFTGGVEGPSPSCLVIILDTNPHAWALLSSTLPLSKAVANLLVFINAHLAVNNANQVAIIASHCHRAVWLYPAPPSASEDIEMGGSTTHGPPNDANKYRQFALIENTLLNSLRNLISSTTEQEVSTTTTTQMAGALTLALSYINKQSLAYNDVSASDSKPTTSDVNTSDSSIGLQSRILVLSVSGDLAHQYIPIMNTTFAAQRMRIPIDILKLAGDTVFLQQASDTTRGIYMHLKNPQGLLQYLMIAFLPDQTSRKDLIAPTQEVVDFRAACFCHRKVVDVGFVCSICLSIFCSPPEGAICLTCSTHLSLGDYGSKPAVVPRKKKKKRKVNGAGVETGSARGTPVPGE
The following text describes a protein:
Function:
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for simple Y, 5'-flap and replication fork-like structures. It cleaves the strand bearing the 5'-non-homologous arm at the branch site junction and generates ligatable, nicked products from the 5'-flap or replication fork substrates. Plays a critical role in maintaining the integrity of the ribosomal DNA (rDNA) loci, where it has a role in re-starting stalled replication forks. Has Holliday junction resolvase activity in vitro.
Subcellular Localization:
Nucleus.
Sequence:
MSQKIQQHQFPDFYCCYLLQSINKRQSFYVGSTPNPVRRLRQHNGKLAVGGAYRTKRDGSRPWEMIMIVRGFPSKIAALQFEHAWQHGYQTHYIAEKDRVVKHKAGGRTLHHKVALMKLLLKHEFFQRMNLIVEVFNIKAWEVWKQDKFFIERDRFPINIQINENALEEPKEKTVDVLMDHSDENLKVVEAVYTKVIENERNIFETFEKKLTTGVVRCEICEKEIDYTSEEQNLKPFVALCNNKDCGCVNHLKCLHRYFLDDEQLMVGRRNLIPRGGKCPKCDMFCDWTTLVKFSTRMKLAHGK
The following text describes a protein:
Function:
Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence:
MWSLLLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITERAGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFRAYLIGGLIALVAVAVSVVYIYNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYPKPHKESQRHAVDALVLNILPEVLERQCGYKLFIFGRDEFPGQAVANVIDENVKLCRRLIVIVVPESLGFGLLKNLSEEQIAVYSALIQDGMKVILIELEKIEDYTVMPESIQYIKQKHGAIRWHGDFTEQSQCMKTKFWKTVRYHMPPRRCRPFPPVQLLQHTPCYRTAGPELGSRRKKCTLTTG
The following text describes a protein:
Function:
Involved in the production of floral volatile phenylpropanoids in flowers of fragrant cultivars (e.g. cv. Mitchell and cv. V26) from cinnamic acid, a common precursor with the anthocyanin biosynthesis pathway involved in flower pigmentation. Methylates caffeoyl-CoA to feruloyl-CoA, also able to methylate 5-hydroxyferuloyl-CoA.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAENGAAVQENQNVIRHQEVGHKSLLQSDALYQYILETSVYPREPESMKELRELTAKHPWNLMTTSADEGQFLNMLLKLINAKNTMEIGVYTGYSLLATALAIPHDGKILAMDINRENYEIGLPVIEKAGVAHKIDFREGPALPVLDQLVEDKNNHGTYDFIFVDADKDNYINYHKRIIDLVKVGGLIGYDNTLWNGSLVAPADTPMRKYVRYYRDFILELNKALAADPRIEICMLPVGDGITLGRRIS
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAKRVADSKPKADRVVVDNSNLTELKATCDEAVERILSRQPGANGSSTKAQGFAPFKVSHFHTDLRLVLGFVASAIMIGTSIWAYFVEKEWKRNKQACAIAVVIYILLSGIQMVDSYLQGNLIFSGTRKTTSDPTEIESLTIASPPLPKATKSNSQTSAGQAILTPPAYTLQIDYTRKSSEAKSLLARKNSSLPLGHLGEWFTEDGEFVEPIFEQRLLSGLEKAFGQ