lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSGSAAVGGKLSREDFRKEKLIEEQRKAGTLPAEVDPETGRDINPHIPQYISKPPWYLDIQHATLKHQRYEDASVSSDMNTWYARGSRQGPAATKYRKGACENCGAMTHKTKECMDRPRKKGAKWSGQGFQADEVIQQVQLGFEGKRDRWNGYNAMDHIKQVEEWEVIEEKRRLKREKEAQEALAAAAAKTTAAKTNESAASKLDGVAAVHNGDADGFKQPAPRSGLVSAEVAAAAAAAAAAVDDSSDDEDEDKYAEKANVAGQKLDTKSRITVRNLRIREDTAKYLRNLDVNSAHYDPKTRSMRANPHNDKDASEVTYAGDNILRYSGDVSKIAQLQSFAWQAEGRGKDVHLQANPTQAELLYKEYQAKKGQVAETQKKSILEKYGGAEHLDAPPKELLLAETEHYVEYSETGRLIKGQEQAKQKSKYEEDIFPLNHTTIWGSWWKDGQWGYACCHAILRASYCGGKAAIEAAKASHEQLIQSSLSNTNTTAPPKKSLLEQYVQRASKEGPAMSKTDYSTKTRLGEGDALLDLNKLAQAREAEQKRKSMGVSELNGDQRDGKRKYNSFNGSGELTEEQLEAYRMERQRGEDPMANYIDEE
The following text describes a protein:
Function:
Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.
Sequence:
MPVTVLMVAEKPMLADSIARLLSDGRCSKRKGMNKICSVSEYNGDFMGQPAFFKVTSTCGHVMGVDFPEEFNNWHRVQPVELYNAPIEKVECSKEMKMNRYLASEAKGVDYLVLWLDCDKEGENICFEVIDAVHGKMKKPRNVDIMSLVYRAHFSAITEYDIKAAMRNLGRPDQNVSLSVDARRELDLRVGCSFTRFQSMFFKGKYAELDASTVSYGPCQTPTLAFCVNRHDEIVNFRPEPYWVIQTEFEARDGSSVKGDWARQRVHDPADAQMYLNRIRQAGVAAVFDINTKRSDRYPPHALNTVKLMRAASTQLGLSPATTMHIAESLYTQGYISYPRTETSTYPTNFDLRGTLSRQTNDRRWGDIASRVMQEGINRPRGGADKGDHPPITPMRSDGGALHGDNARVYEYVVRHFIATLMRNCVYEVTTVKMNCGEEEFSFQGKQLIDPGFTLILSASGAEKDVWMPRVERGDQMRLKSAEVVDRQTIPPSYLTESELISMMEQHGIGTDASIPVHINTICQRNYVTVETTSRRLIPTQLGVCLIHGYHAVDPELVLPTIRADLERQLDMIASGQADFMTVKNHAVDLFRRKFLYFKDNMPRFDALFAATFRTVSVEERQSTVCPKCRVNSKTPGHIHCQQCKDASKRGADIRSAGVVTRGSRGGRGRGTARGASTRGGPSLRATRGARLRGAVATRGTRSTRGRGSTARGASSGGGGGESNANLMPLGTPGGRGSSLPPIRGARGSPAGPPPPRGRGMPPRGGGSNAFVAPPPLPMPPPIRPPVQQQQQQRYQQQSNMSPPPLPMPPPIRPPAQQQQSRMPPPPLPMPPPLPHQRYHPPSAPSTSTSIPPQAARHSAPWPTEASPPKRVKQEPQGSLHWPPNYAQPSAAAPGTWQPNDGPSQTWQPSAHQPPRPTHNGAMKREEIDFTADVEVSTAQPKRESWIPSDEFS
The following text describes a protein:
Function:
May function in G-protein coupled signal transduction.
Miscellaneous:
MISCELLANEOUS: Present with 1160 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKFADHLTESAIPEWRDKYIDYKVGKKKLRRYKEKLDAEEEQSSSYRSWMPSVSVYQTAFQQREPGKSRSDGDYRSGPAFKKDYSALQREFVADFIEDWLISFQLSKCNEFYLWLLKECDKKFEVLQSQLHYYSLQKNYERDNLNRSSSNVDMSTSLYAAGLAGRSDSRVNSIDSDSRSVMYGSMPCTKEAKKPRLSLLAYCQKVLKDNRLLPSWPKRGFSLLQDLRQDASSRGRETFAFGASFLETMTTTQARNLLSNAIIEYYLYLQLVKSFRDINVTGFRKMVKKFDKTCHTRELTTFMSYARTHYTLFKHADANVQLVAQKMQQITSSQPTPTSELSSAQRDKEPITWLETQITEWFTTALTNSPKDRKHNTHKLKKLTIQYSISEQMVHRNNRSIVQMLVVGLGIGVSMTLITYTLYLGISSEETSFTHKILFPLWGGWYMVLLIAFLFLVNCFIWHRTGINYRFIMLGEIQSKNGTQFFNNDFATSKIPLKLYFLTFFIVPCAVCSMLSFALEKLTPLGFLYIGIVSFLFLCPSGLIPYWDKVVHTRKWLVVTLIRLMMSGFFPVEFGDFFLGDIICSLTYSIADIAMFFCVYSHTPNNLCGSSHSRAMGVLSCLPSYWRFMQCLRRFADSGDWFPHLLNAAKYTLGIAYNATLCAYRLSDRSEQRRTPFIVCATLNSILTSAWDLVMDWSFAHNTTSYNWLLRDDLYLAGKKNWENGSYSFSRKLVYYFAMIWDILIRFEWIVYAIAPQTIQQSAVTSFILALLEVLRRFVWIIFRVENEHVANVHLFRVTGDAPLPYPIAQVGDDSMDSSDLGSKAFSSLNDIPITPSHDNNPHSFAEPMPAYRGTFRRRSSVFENISRSIPWAHATDFQRPTVNTVDDRSPETDSESEVESIM
The following text describes a protein:
Function:
Transient component of P-granule which is involved in germline development.
Subcellular Localization:
Cytoplasmic granule. Note=Localizes to P granules only during postembryonic development.
Sequence:
MKPCKREIVDFDGIRTHFFPNLALYTCYNEELIAHHSENANRFTSYVFGAVEDSPTEQEILEILFPENANPEAISTGMDACLALGENFLSHYKSFNARLNRQNHSHDLLDAVQEFDEKKILAISRKSRLRKSADSKILTILVNILLSENQEEKFMEICELCSLDLDFDAFVLIKILQLENEENAEEVQIIRENVVDQILEQKPFLAHLLKNGPEKIDEITKLLSVPIIGSSSNQINQLITKICDSSEISDTAVEEHYHQNFKLMNILVRTMIVDRFDLTIDALEQIPVEIKNRMFPGIRIRVLQDTLHFLHQLFKVFLNESQKFDNLAPQSFAKAIKNVWVRHAIIGILDSLKFSLNKDVFNQLVPLIPGSQVSNDVISGKVENAISCAIWIVKTFGTEGSRDSIEKLPWFDSSVELTELINSIEIAVTSVEVEDQTVNFRKIPQKDWLDGNLQKALKTEPTSEKFGISNSLKIKDENQRNQIRGFKDNSKEPNAKVSARFGSKFQRVDSSTKRRLFGGVGVGEPRNCRGFL
The following text describes a protein:
Function:
Does not possess nicotinamidase activity in vitro.
Sequence:
MAERWRNTALLVIDMQNDFIEEGAVTQVKGGKSIVPNVIRVVELARQRGILVIWVVREHDRQGRDVELFRRHNYSSEKVGPVIKGTVGAELVDGLMINEEDDYKIVKTRFSAFFSTNLHSFLQTSGVTKLVIAGVQTPNCIRQTVFDAVALDYPNVTVITDATAAATPEIHTANILDMKNIGVKTPTLHEWSEELA
The following text describes a protein:
Function:
Essential component of the mitotic checkpoint. Required for normal mitosis progression and tumor suppression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. Essential for tumor suppression. May play a role in regulating aging and fertility (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Cytoplasmic in interphase cells (By similarity). Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and KNL1 (By similarity).
Domain:
The D-box targets the protein for rapid degradation by ubiquitin-dependent proteolysis during the transition from mitosis to interphase; The BUB1 N-terminal domain directs kinetochore localization and binding to BUB3.
Sequence:
MAEASEAMCLEGAEWELSKENIQPLRHGRVMSTLQGALAKQESAGHTALQQQKRAFESEIRFYSGDDPLDVWDRYINWTEQNYPQGGKESNMSALVERAIEALQGETRYYNDPRFLSLWIKLGHLCNEPLDMYSYLQSQGIGVSLAQFYISWAEEYEARENFKKADIIFQEGIERKAEPLDRLQSQHRQFQSRVSRQAFLALGNEEEEALEPSEPQRSSLAELKSRGKKMARAPISRVGGALKAPGQSRGFLNAVPQPVHGNRRITVFDENADTASRTELSKPVAQPWMAPPVPRAKENELQPGPWSTDRPAGRRPHDNPASVTSIPSVLPSFTPYVEESAQQTVMTPCKIEPSINHVLSTRKPGREEGDPLQRVQSHQQGCEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKERREAELLTSAKKREEMQKQIEEMERRLKAMQAVQQEGAGGQQEEKMPTEDPARLQIASGPQEMSGVPLSCSICPLSSNPREISPAENILQEQPDSKGSSMPFSIFDESLSDKKDKSPATGGPQVLNAQRRPLSVLKTTEVGTTNEDVSPDICDELTELEPLSEDAIITGFRNVTLCPNPEDTCDFARAARLASTPFHEILSSKGIAADPEGLLQEEDLDGKAAEAHHTVHHQALIIKKLSPIIEESREATHSSGFSRSSSSAPSTSSIKGFQLLEKLELTNDGAEDAIQSPWCSQYRLQLLKSLLELSAFAEFSVEDRPMPVLEIGKEIELGPEDYVIKQEHLTCDDYRLFWVAPRSSAELTMIKASSQPIPWDFYINLKLKERLNEDYDQLCSCCQYQDGHVVWYQYINCSTLQNLLQHSEFVTHEIIVLIIYNLLTIVEKLHRAEIVHGDLSPRSLILRNRIHDPYDYVNKDDHAVRIMDFSYSVDLRVQLDAFAYSGFRTAQILEGQKILANCSSPYHVDLLGIADLAHLLLFKEHLHVFWDGLLWKLSQSTSELKDSELWNKFFVRILNASDKSTVSVLGELAAEMGGAFDATFHSHLNRALWKLGKTISPEALLTQQDKQPGGSQSPA
The following text describes a protein:
Function:
May be involved in vacuolar sorting and osmoregulation.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MDQTKPPRRNPLAFTPWPVTLITAVVYLAFVIPLLVIHHVVPSAPTSSPDGLNITEAWNDLQVLTAGYRPYNSRQNDKIHDWLLHRINEILGAAPPATTDEKKPDVFVFDDTRSNLTFARDNLAVYFEGTNILVYIRGEDDDQEQWWELPEGSPKGKGGVLVNAHYDSVSTGYGATDDGVGVVTCLQLVKYFTTPKNAPRKGLVVLFNNGEEDFLNGARVYSQHPLSRFPHTFLNLEGAGAGGRAVLFRSSDAEVAASYMRSKHPFGSVLGSDGFKAGLIRSQTDYVVFEGDMGLRGLDVAFLEPRARYHTDQDDTRHTSKDSLWHMLSTAVATTEDLVSDTSDRFDGPARNDHKIASGTGHQAVWFDLYGSTFVLFRLHTLFALSVTLLVVAPIVLLLTSIILTKVDKMYLFRTSIRPEGSLEVLPLYGDRGVIRYPFLLGIPTAVTIGLAYLLTKFNPYIVHSSQYAVWSMMVSVWIFLAWFVSRVADFARPSAFHRVYTLTWTFVVMWVLQVIATVYQDRWALGGSYFIFFAYAGTFLATWISYLELFALPRKSEYANHLRPVSRHASSHSSRRGLSEEDEEDEDEAPTESTSLLGSRQRTTFANYVRVNADTADLSDSEEHTQDVNVYGLEQRWSASLPKWLWLLQFLLAAPIVLILVGPIALLLTGSLHQTGQDGSSSLFIYIAIVALTTLLLSPMLPFVHRCTYHIPLFMLAVFAGTLIYNLVAFPFSDSNRLKLFFIQEVDLDTGLNTASLTGVQPFVHDVAVGLPSAAGQNVTCGPFGDRFKCSWTGIPPHVLTEDKPVEEWLSFEVSRSIDKPRHAQLQISGQNTRACKVVFDSPIKNFHVAGSAYDPRFPHTYAKGIKEIRLWSRVWDNTWTVDVEWFNPDSSSDHSKTSGSLTGQVVCLWSDYNQPGTIPALDEVRQYGPAWIGVSKLADGLVEGRKSFEIA
The following text describes a protein:
Function:
Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus leading to their ubiquitination and degradation. Also directly recognizes the C-terminal glutamate-leucine (Glu-Leu) degron as an alternative degron in proteins leading to their ubiquitination and degradation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
Sequence:
MASTVSWRHHLHVDADSSQNGMSSHDSRRLDLVHDSADILGSSTSNSTNHYSSDLVGHFKRFTTRRIEGWKYPSTFTEGPNHDHASRYYVEKEPCNVVDYLKSREMIASHRNRPQYRHRPTMDAITIDARSDPITIRCPDCKCPRYSGVGSVPVSRCHSPSPQVNANSSVEPECLEFPPKTQSTSPIYAGVDWASIVKPLTGALWPVLDIPSTIVQTPSPINSLSDSRSDCLDLQKDLDMPFELDNIPPSSPSDEGSTTSTHGDFSSLLLMERPSFVSNSAADKKLRCATCSAQMRLGMHENFMSAGESRLSSFVTRHLPVALSESAFLMENTDKIFASAWLSDSSVVLGTKCNKLQVLDVDSGKRIDIPTFAACNLIPQSKSSQETASNSARGLYQPFSTLSLQQQRPLQSAALHHCAGIHSISINPSNTLIAVGGGDPTNLVQIYHLPTFEPYALLKGHTDVVFSVAWLDDTTLVSGSRDAQFMHWSLNSLHISDSLYQYPLNHFVSVYSPLSMKKEHMGKVRDLKYDHHLKHAFTLSSDGFVKVWDVAGTSCKVSSSIPLHHSNETVCLALDTTHHLIAVGSQNHVSLLDPRIGSVVHMFESSDEGWGVRSLCMDRDTVTVGGGLGRISFYDLRAQKYLSWRKSTVWNKHSTLCTRAFSRTLAPFNDHLPVNSPELHGLDFELSTQIFSHVGTRTHPTLQQYTQSCQPDFTQPNHSYLQSGKGWLHRDEIYTTHFQGVDISNAVYTLSYNSKGNRLFTAGGPLQLNLRGSYAGVWQ
The following text describes a protein:
Function:
E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate (By similarity). Acting downstream of probable Golgi transport protein eas-1, involved in inhibition of activation of transcription factor sbp-1, thereby playing a role in regulating AMsh glial cell size.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network. Golgi apparatus, trans-Golgi network. Note=Localized to cis-Golgi during larval L1 stage, but localized to trans-Golgi in early adulthood.
Sequence:
MEGVMENVGGLMQNIRRRHMSITEMTEESVRLGVAQMDTGFKKIKEMSIMVLETGLRLPGLLFIELLWRYQGFSFEDISDDMMKQTPLSYFDIPTMLDFVHRRNFDHHAAIILSYFVIFISLMFLTLPLSRLIRMYSHFLSVFLFGVAYKLSAIYVDLEMKTGEEELKLDGLIKLERHGFHFLAQMLLVVLQSMLLEVDGEPWRVALPVFALPIVARMCGCPMDKLKNAHNYACTGTMIFIATYMLYRAPSLIKSTKTALRQIKAVFMVHGLADGVAVLWRKLRILELLTFTWITMFLMVLYVELIDKGRTWSEVGRILLTGVAETTNTPITLAALAVSVSYVCKWIADLTKLITGGTRSHGHVLAHSGYTEAVSVVILCIQTGFLGMQVEQKTILLALVLYIVISALLQSLFEIIEVVLLNLPSSPTASRARHARCICIALLLVVIPFFTTKTMLALLPIDIYTAIIIANSATVTARAIGVILKYIVLIVETKSEEPWEGIDDLTYYIDCANKGIELLAAKVVMVFGCMQVVKVGFSFATFAILLFHVIVNIYKRLEHTVSFIKNRNAAVKNINRLSKADVVQLREREDVCAICFIEMKEEARITPCKHYFHGPCLRKWLAVKMVCPLCYTYMKEDDFDSKSSSSGTLNEVQQNEEGAAVEENPENPEEQPEAPNAERAPGDMFDWDDLFGFRAERETRNRNEQRIHGARDMWPLLVDNDAYESDSDAGSEELVIEEENNN
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEAVYLVVNGLGLVLDVLTLVLDLNFLLVSSLLASLAWLLAFVYNLPHTVLTSLLHLGRGVLLSLLALIEAVVRFTCGGLQALCTLLYSCCSGLESLKLLGHLASHGALRSREILHRGVLNVVSSGHALLRQACDICAIAMSLVAYVINSLVNICLIGTQNLFSLVLALWDAVTGPLWRMTDLVAAFLAHISSSAVAMAILLWTPCQLALELLASAARLLASFVLVNLTGLVLLACVLAVTVTVLHPDFTLRLATQALSQLHARPSYHRLREDVMRLSRLALGSEAWRRVWSRSLQLASWPNRGGAPGAPQGDPMRVFSVRTRRQDTLPEVGRRSEAEEEEARTIRVTPVRGRERLNEEEPAGGQDPWKLLKEQEERKKCVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPLCRRGILQTLNVYL
The following text describes a protein:
Function:
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein.
Sequence:
MDTLAKNSDVTVGAFAVPPRTEYKGMALYIGANIAALVFFLWSLSPTWLLHYLHIYYFPSRWWALAIPSWLIAAFIFTYVFLTLYNIEVMTYPLDRLEVIVDEHARVDGGKNGEYFWEATDGVWDLPLVDVSKVLYGDDSE
The following text describes a protein:
Function:
Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MSHNEQHGGFVKLLEKDADVQIVDHRRKNLPANAYSYQFIEKSIQKGRLENLEAYKAGPSTTRPVGASNIPTKGQRAAFTIEEDQLIYDYMQHYERDPLSSVMGNKIYQLFAANHPGHTWQSWRDRYLKRLRGRPRPGGMSKSNDATAVREEDRKSQPIPAPTSTAHPVVPATQRDETSVQPRERKRKRSPEPTVSGSRTSNGTLSTQQRTTNRHPTPSAPQVATISPASASQQRKLPQLDTLPSPKRVKTTTTRISGIILPQENGPTEEAMDKDPADESNTSIDSVFLELPFLPSSPVAEEAPEQDIDSWIDSRVRAGKGSEDQVIEALQCTSMDPDLAEKVLESLSAGKGIPTNMRGVWTAQDDRDLEAQNTRDIQRVIEKHGDLLNYRWDYLNMTRAAAR
The following text describes a protein:
Function:
Component of the spliceosome involved in mRNA processing.
Subcellular Localization:
Nucleus.
Sequence:
MSQPLPPGWTEHKAPSGIPYYWNAELKKSTYQRPSFIEKNHSSSVTASQASLAFNTSEKLFVNENAEERKNSRDLRKQLPDRPKFKKRIPNNDSWVVVFTKKNRYFFHNLKSHESYWEPPLEISKDLKILRLPIRKQISKDSSQSQNVDSGKTNHEEIHESRHLQTEIEEPSGLEESSEESVLYSEEFYEKSDEEEDEEKSHSAEELEFGEEDIMYQLQQLDDETVSYDIQEQATNLSTDDARRVFTELLKDKNIGAYQPWELVYPKLLDDDRFYVLDSGERRKEVFEEYCKSVVSTKKITRRKNTLSDFWTLLHSLPSTLLWPQFKRKYRKSSTLQIPGYSERDFEKLFREFQILRKQPMQDKLLNFKKLCKSKTVDPKNPDEFTESILNDTRYAVLTREELDSLACSSN
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MDGFSRDFLRGIGKGDAPPPEQRPGQPREAMEEDVELSLELSLGGLFGPARKRDKDKLPRPSSAAAMMTPVDVPAPPAHPRASGSPSSASPEGDGQRFLGSGTLMRTSSLPAVTEAAGNEEWKKRKEAQSLRRLEVKKKRIERRNSLTCSTSKEVTRQIPEKMNAHTDKLASCDEAVVGNNENHSSGKHLAKGKAPKHQAAITSQASLSAMRKKPNSAFKGKAVTKENKSSSSVPSGEATSSVTAASPPPPSSLAPRRAAALGSRGDGRAAVPQVQIPWGNVERRLMQEMPGVLTKGLPNKVDGFLYKYREGDDMRIVCLCHGSFLTPSEFVQHAGAVNGEAANPLQYIFINPTPNL
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MDKMDVNMEVSDKLRDEKNDLETGLSIQTLPGSPKIDAEVKPARKKINKRKKKKMKATVNNEIQSMDQSKTEPTESPAEGNVNLKRKRRKRIRRSVKKGKQIQSTDQEDGMLDLHLSDGQGIEGKLAEKECTNQETEPCARNELSLSESVHDKESPLNLCKDEETILSPDMVVVSTNEVPVELVEDSQHSSNPNQITVENAISENELNEVNEAMIVDRVKCSTESRSCDVEMSTALSSPEMKEAECLSEDLGQDPIIAPIASVKRKLIVLDVNGLLANIVMPAPKDIRGDTHILGRAIFKRPFCDDFLKFCFQNFDVGVWSSRSKRIIDRVVDYLLGDLRDQLLFCWDMDHSTQTGFKTLENIHKPLVCKELRRIWENDDSDVRWKKGDYDESNTLLLDDSPYKALLNPLHTAIFPNSYNYVDKDDNSLGPGGDLRVYLEGLLNSEHVQKYVEQHPFGQSAINDTNLSWDFYSGVLQAISNQPHDNTPNSVPTS
The following text describes a protein:
Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
Subcellular Localization:
Cytoplasm.
Sequence:
MRRAEDAKTLLILPLFTYILAEIIDENEVIGDPEIECGPSSIIVNWRIRKPFDGTVFVKGLRSREECINTSRGREVAGIEIPFESCGLIRSRSLNPRGIFVAATVVLSFHPLFITMIDRSYRVQCFYMENDHQVNARVGVEELSTTLITNSPSLPSCKYEILDGSITGPPVSSASIGQKVFHKWSCKTEAVNTYCITVHSCIVNDGLGQRVSIIDEEGCAMDERLISQLEYTNDLVVGQISHVFKYADKEELFYECHLAISIKEVGAECPRPVCIPPPSSSPSPPSIPPQSNPSLPVHTFPSATPYRRRFRSIPHYEIDVTTQLTATNAKIEESTMDITRSSCISSILLFTLIPFSVISILVVFTAIFVICLKKTGKAMLPVQILKDHAQEERGDSARLSSFVGAIAIGDLVKTTLGPKGMDKILINGNPDRNDIKVTNDGATILKSIGVDNPAAKVLVDISMAQDNEVGDGTTSVTVLASELLKEAEKLINMRIHPQTIISGYRKALKLSQDALRECAIESGSKMREDLLKIARTTLSSKILSQYNELFSTLAVDAILRLKGSANLDAIQIIKKLGGSLNDSYLDEGFLLEKLPGMYQPRRLENAKILIANTPMDTDKVKVFGSRVRVDGVAKVAELEAAEKLKMKEKVDKILSHKMNVFINRQLIYNYPEQLFADANVMAIEHADFEGIERLALVLGGEIVSTFDTPEKVKFGQCDLVEEVMIGEDRLMRFSGVALGEACSIVLRGATNQILEEADRSLHDALCVLMTHVKDSKTVPGAGASEIIMSNAVLNGAQKVAGKEALAIQAFGQALSALPIIISDNAGLDGADLVTRLRAEHANGNHRMGINVEEGIISDVIELGIIESLQVKMCMVSSAAEAAEQIIRVDDIIKCAPRPRAPDNRPC
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. May represent an important antioxidant defense against cytotoxic peroxides, especially peroxynitrite, which can be formed by activated macrophages during infection.
Miscellaneous:
MISCELLANEOUS: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule. C(P) can be reduced through a mixed disulfide with the N-terminal cysteine of mycoredoxin-1 (Mrx1), resolved by its C-terminal cysteine, or by a mixed disulfide with mycothiol, resolved by a second molecule of mycothiol or by mycoredoxin-1.
Sequence:
MLNVGATAPDFTLRDQNQQLVTLRGYRGAKNVLLVFFPLAFTGICQGELDQLRDHLPEFENDDSAALAISVGPPPTHKIWATQSGFTFPLLSDFWPHGAVSQAYGVFNEQAGIANRGTFVVDRSGIIRFAEMKQPGEVRDQRLWTDALAALTA
The following text describes a protein:
Function:
TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
Subcellular Localization:
Nucleus.
Sequence:
MEKVEAVTVSNVDPYRRILNKVVSQLLLDKGAGQASNHSLETLTQMLQALIWEIGNSAHNYCELSGRTMPTVGDVSLALINMGISISNLDPYMRKETHVPIPLPPQQTQQRPLSLLQAGIKAPHPHYVPSYFPPMPDPHAYIRTPTHKQPVTEYEAIREKAACQKRDIEKALTKFLCKTTETNNLFPTEDNMFPLIACKPAFPPYAAALNPTDQVFDFEELEYHYLVANRTEDEPSKDDGEEGDSENEEMDGDKSKEEKPELDIKPNSNTNKAILENPNIDNPYLRAATLPKRSKNCPTPGTMPSRSLATTAPTIRTPSTLEITKTNL
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MLGPGQVRLRPRVWRDKAGGRVADGASGLPPARGSWRETGTGRALGASSPPRPAQGSSSPGIQSGPSSRPGSPRGAEQAGTPRPRLSLGISQATGSAARWRTRRTGKGLGYNSDEIRPRTLLIEHLMEGGRRDHHTMTVLWGTQEIIVAEFHKKIKEAFEVFDHESNNTVDVREIGTIIRSLGCCPTEGELHDLIAEVEEEEPTGYIRFEKFLPVMTEILLERKYRPIPEDVLLRAFEVLDSAKRGFLTKDELIKYMTEEDGVSLRRPG
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRFFAASDSSSEESSEEELYSDNEASAQEDSDKDSDDDDSDDDDSSSGSEAGGANRFLKDADSDSESEDEDQNKVLKSAKDKRFDELEATIRLIENAQRINDWAVISDQFDKLNRQAPTLMKQNDGKVPKLYIQAIADLETVVLETHEKQKVTPKKMNAVNTRGFNAVRQKVKKHNREFQKDIDLYRENKDEFMRETEEVEAAPKEKKKKSKIPQLGTEIVDEATDDGFITVGAGGKAVQYTPEGILKHLRAIVEQRGRKNSDKLEHIRTLEKLFDVSVNDYQRIRVLLTLISTRFDLTSGTASHMHQDQWKLADQEFGKLLEILENTKEIVVIENAEEWEDDDKLPPIEEGQIFRIPGSVVSFVERLDDELTRSLQHIDPHTAEYVERLTDEALLYAQLVRALIYVESLKKNASLELPQESLNRVVMRRLEHVYFKPSQVVTIMEANSWKAVPETLDSEVTPRAISNDTTSLVQTLSTYLFQNSEGIIRARAMLCQIYFLALHDQYYKARDMMLMSHLQETISNFDVNTQILFNRALVQVGLCAFRAGLVYESQNSLQEICGSNRQKELLAQGLQMQRYSQISPEQERLERQRQLPFHMHINLELLECVYLTCSMLLEIPLLAQLGSSPDLRKRVISKTYRRLLEYHERQIFTGPPENTRDHVMQASKALSAGEWKKAAEFINSIKIWELVADSEKIKEMLSAQIQEEGLRTYLFTYAPYYDTLAVSTLASMFELSERKVSAVVSKMISHEELAAALDQVNSAIIFRKGVELSRLQTLALSLSDKASGLIESNEKTLEQRTQGTANAFERQGGRGGRGGGRGRGGGRGGGVPRGGRNQQFTGGALGRAIQA
The following text describes a protein:
Function:
Activation of RuBisCO (ribulose-1,5-bisphosphate carboxylase/oxygenase; EC 4.1.1.39) involves the ATP-dependent carboxylation of the epsilon-amino group of lysine leading to a carbamate structure.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MASSVSTVAAANKVLLSLNNSVAGNSAPSTVFFGKTLKKVNAKGTSSPKVSKRSFRIVGAQEIDEKKQTDQDRWKGLVTDMSDDQQDITRGKGMVDPLFQAPVGTGTHHPVLSSYEYISQGLRQYNLDNTLDGFYIAPAFMDKLVVHITKNFLTLPNIKVPLILGIWGGKGQGKSFQCELVFRKMGINPIMMSAGELESGNAGEPAKLIRQRYREAAEIIRKGNMCVLFINDLDAGAGRMGGTTQYTVNNQMVNATLMNIADNPTNVQLPGMYNKQENARVPIIVTGNDFSTLYAPLIRDGRMEKFYWAPTREDRIGVCKGIFRTDSVPDEHVVRLVDAFPGQSIDFFGALRARVYDDEVRKWIEKTGIEQVGEKLLNSIEGPPKFEQPKMTIDKLLEYGYLLVQEQENVKRVQLADKYLKEAALGDANADAINMGNF
The following text describes a protein:
Function:
Required for the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. Does not have deaminase activity but binds to dsRNA and regulates A-to-I RNA editing, possibly by modulating the accessibility of the double-stranded RNA-specific adenosine deaminase adr-2 for target adenosines. Regulates editing efficiency of specific adenosines in 3' untranslated regions of target mRNAs. Represses editing efficiency of the Y75B8A.8 3' UTR in neurons. Required for correct expression and A-to-I editing of clec-41. Required for normal chemotaxis. Also required for normal vulva development. Plays a role in determining lifespan. Not required for RNA interference. Likely to play a role in determining whether a dsRNA enters the RNAi pathway.
Miscellaneous:
MISCELLANEOUS: Can prevent somatic transgenes from inducing gene silencing via the RNA interference pathway. This may occur due to A-to-I editing of transgene-derived dsRNA, preventing transgene RNAi.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Detected both in the nuclear fraction and in the ribosome-containing pellet of the cytoplasm.
Sequence:
MDQNPNYNFGYGQAYGSGTDHTSDSTNNYNWASQWSQPESAASLATHTFPQYVSQQQQQQQQQAQQQAQNTYAAMNPISTFMQQQQRAQTFPQKKYGQQGGAPKPSAIRNNNFGAFGGGHALSQEWVQPMSQNQMGGPQGNRFFNNQKGGPFNQNKPNWRQNKPKGPAAPKKFDSTGKSPAMLLHELFKDVSEEYTEVEGVPKKYCCTLKVNGRTFQMESVNKKAAKQKCSELVVRDLRPDVHVTPFEEGVAAKAAAPVKKEIDAASGNGQNNKRNLLQADAISNQPTPKKVSAVKKAKLQLTPVESALSLLDLMQKIIAESAEKYSPVFEASEVPKDPEIPEVEVKKEEVDTNGENVANEKKSGWRKNETMHNVTLKFVEQNKQYTKMGPSRGVLKDMVIREALRDLFNVSHADITTVARRHASNRLGHDTTILQCLNTICSILNCTLTIECEPAEDRPLGIGRAYFMAKCTIIDHNENDLKFEVKSSSLASKAMAKDWVAQETLKNYFAIDPSSCVKTDAVSSQGPCALLHAMLNKQTKQKCKIAYEFKDNVPPVAGQATTTFYCECVIDETDRYIGVGRSKKLAKSEAAMQALKKLFKIDYDPAGNYPLALTSRAMTESKVSPLCRHIAEFCKREYHQMTEYYQIPPSNLFAAFLLVNAQEEKRVLAMGSSIQYIVEPDTLSGANGTSLLHLDAIILARRAMLKAFIHELSTVDSECSIFEKKEEGKAALKPNLRLVLYSNYSPPCIHAVDDAATKKLSYVTPTNLTCVPDDVLTYEQIKETKSLRVHCTADKLFKWNTLGIQGALLSNVLHPIFIDNIFFGSEAPVSDESLSYALQGRLGPNENEREIIVESMPVQMRMHMGISHLWHRGVDSVETLDYNTGRTSKGSPSRVCKAEIFEAYRKLNGVDQAVVNYAKAKEMASEYQYEKKVFYEKLEAAGLGKWQTKPAELVDSFTLAAFD