lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Carboxylate--CoA ligase that may use 4-coumarate as substrate. Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester.
Domain:
Both substrate-binding domains (SBD1 and SBD2) are involved in the substrate recognition, and are sufficient to confer the substrate specificity.
Sequence:
MADRAPPPPPPPAGIDSRSGFCAATRIFHSTRAPGDLPPESLPMTAAAYAFSLLSSSTLPGRPALVDAATGIAISYPSFLAAVRSLAGGLWCSLGLRPGDVALVVAPSRLEVPVLDFALMSIGAVVSPANPVSTPEEYAHQVALSRPVVAFAAPEVAAKLPEHVRCVVIGSDEYGRLAASDGRRAAAPAAVAVKQSDTAAVLYSSGTTGRVKAVAITHRNLIALMSLHADNREKVAREAAEAGEEPPPPAVTLLPIPLFHVFGFMMVLRSVSMGETSVLMERFDFIAALRAIERYRVTLLPAAPPVLVAMVKYEEARRRDLSSLLVIGIGGAPLGREVAEQFASVFPNVELVQGYGLTESSGAVAATVGPEESKAYGSVGKLGSHLQAKIVDPSTGYVGDDEATAATVDSEGWLKTGDLCYFNEDGFLYIVDRLKELIKYKGYQVPPAELEHILQSHPGIADAAVIPYPDEEAGELPMAFIVRQPGSNITKEQVMDYVAKQVAPYKKVRRVAFVTAIPKSPAGKILRRELVQQALSMGASKL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQMSLSRDATKECLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPLVPYPEKFSEDGVGNPEGKILSGTPTCKRRVISLLVTIENHTPLVELSEYLGTNTLSEILDSSWEGAKNVYKCPECDQNFSDHSYLVLHQKVHSGEKKHKCGDCGKIFNHRANLRTHRRIHTGEKPYKCAKCSASFRQHSHLSRHVNSHVKEKPYTCSICGRGFMWLPGLAQHQKSHSAEKAYESTNRDKHFNEKPNLALPEETFISGPQYQHTKCLKSFRQSSYPALSEKSHDEDFERCSDDGDNFFSFSKFKPLQCPDCDMTFPCFSELISHQNIHTEERPYTCKTCEKSFALDSELACHQKSHMVEETFKCTVCGKSFRSNLHLITHKRTHIKNTT
The following text describes a protein:
Function:
May be involved in the regulation of cell differentiation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MYRFSNTVIGVLNLLTLLASIPIIGTALYKARSSTTCENFLQTPLLVIGFIILIVSLAGFIGACFNVAWALWVYLVVMIFLIATLMGLTLFGLVVTSQGGGVEVPGRIYKEYRLGDYHPWLRERVRDPEYWNSIRSCILSSKTCTKIESWTTLDYFQRDMTSVQSGCCKPPTACTYEAGVVDGGGDCFRWNNGVEMLCYECDACKAGVLEEIRLDWRKLSVVNILVLVLLIAVYAAGCCAFHNTRHAAHPYHPSDDNRMTRVRPRWDYYWWRWWHEKKEQLY
The following text describes a protein:
Function:
Pore-forming subunit of gustatory voltage-gated ion channels required for sensory perception of sweet, bitter and umami tastes. With CALHM1 forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to membrane depolarization and low extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of small ions including Ca(2+), Na(+), K(+) and Cl(-), as well as larger ions such as ATP(4-).
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MDKFRMLFQHFQSSSESVMNGICLLLAAVTVKLYSSFDFNCPCLVHYNALYGLGLLLTPPLALFLCGLLANRQSVVMVEEWRRPAGHRRKDPGIIRYMCSSVLQRALAAPLVWILLALLDGKCFVCAFSSSVDPEKFLDFANMTPSQVQLFLAKVPCKEDELVRDSPARKAVSRYLRCLSQAIGWSVTLLLIIAAFLARCLRPCFDQTVFLQRRYWSNYVDLEQKLFDETCCEHARDFAHRCVLHFFASMRSELQARGLRRGNAGRRLELPAVPEPPEGLDSGSGKAHLRAISSREQVDRLLSTWYSSKPPLDLAASPGLCGGGLSHRAPTLALGTRLSQHTDV
The following text describes a protein:
Function:
Major secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Plays a role in the morphogenesis and autolysis (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MRFATSTIVKVALLLSSLCVDAAVMWNRDTSSTDLEARASSGYRSVVYFVNWAIYGRNHNPQDLPVERLTHVLYAFANVRPETGEVYMTDSWADIEKHYPGDSWSDTGNNVYGCIKQLYLLKKQNRNLKVLLSIGGWTYSPNFAPAASTDAGRKNFAKTAVKLLQDLGFDGLDIDWEYPENDQQANDFVLLLKEVRTALDSYSAANAGGQHFLLTVASPAGPDKIKVLHLKDMDQQLDFWNLMAYDYAGSFSSLSGHQANVYNDTSNPLSTPFNTQTALDLYRAGGVPANKIVLGMPLYGRSFANTDGPGKPYNGVGQGSWENGVWDYKALPQAGATEHVLPDIMASYSYDATNKFLISYDNPQVANLKSGYIKSLGLGGAMWWDSSSDKTGSDSLITTVVNALGGTGVFEQSQNELDYPVSQYDNLRNGMQT
The following text describes a protein:
Function:
May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Note=Found mainly at the interface between amorphous elastin and microfibrils.
Sequence:
MWQPRRPWPRVPWRWALALLALVGAGLCHAGPQPGYPARPSARNKNWCAYIVNKNVSCSVLEGSESFIQAQYNCAWNQMPCPSALVYRVNFRPRYVTRYKTVTQLEWRCCPGFRGGDCQEGPKDPVKTLRPTPARPRNSLKKATDNEPSQFSEPRKTLSPTGTAQPSWGVDPKEGPQELQEKKIQVLEEKVLRLTRTVLDLQSSLAGVSENLKHATQDDASRTRAPGLSSQHPKPDTTVSGDTETGQSPGVFNTKESGMKDIKSELAEVKDTLKNKSDKLEELDGKVKGYEGQLRQLQEAAQGPTVTMTTNELYQAYVDSKIDALREELMEGMDRKLADLKNSCEYKLTGLQQQCDDYGSSYLGVIELIGEKETSLRKEINNLRARLQEPSAQANCCDSEKNGDIGQQIKTLDQKIERVAEATRMLNGRLDNEFDRLIVPEPDVDFDAKWNELDARINVTEKNAEEHCFYIEETLRGAINGEVGDLKQLVDQKIQSLEDRLGSVLLQMTNNTGAELSPPGAAALPGVSGSGDERVMMELNHLKDKVQVVEDICLLNIQGKPHGMEGALPNREDRAVRDSLHLLKSLNDTMHRKFQETEQTIQKLQQDFSFLYSQLNHTENDVTHLQKEMSNCRAGENAGMGRFTKVGEQERTVDTLPSPQHPVAHCCSQLEERWQRLQSQVISELDACKECTQGVQREVSMVEGRVSHMEKTCSKLDSISGNLQRIKEGLNKHVSSLWNCVRQMNGTLRSHSRDISGLKNSVQQFYSHVFQISTDLQDLVKFQPSAKAPSPPPPAEAPKEPLQPEPAPPRPSGPATAEDPGRRPVLPQRPPEERPPQPPGSTGVIAETGQAGPPAGAGVSGRGLPRGVDGQTGSGTVPGAEGFAGAPGYPKSPPVASPGAPVPSLVSFSAGLTQKPFPSDGGVVLFNKVLVNDGDVYNPSTGVFTAPYDGRYLITATLTPERDAYVEAVLSVSNASVAQLHTAGYRREFLEYHRPPGALHTCGGPGAFHLIVHLKAGDAVNVVVTGGKLAHTDFDEMYSTFSGVFLYPFLSHL
The following text describes a protein:
Function:
Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2+)-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose.
Subcellular Localization:
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP).
Domain:
The number of the intragenic tandem repeats varies between different S.cerevisiae strains. There is a linear correlation between protein size and the extend of adhesion: the more repeats, the stronger the adhesion properties and the greater the fraction of flocculating cells (By similarity).
Sequence:
MTIAHHCIFLVILAFLALINVASGATEACLPAGQRKSGMNINFYQYSLKDSSTYSNAAYMAYGYASKTKLGSVGGQTDISIDYNIPCVSSSGTFPCPQEDSYGNWGCKGMGACSNSQGIAYWSTDLFGFYTTPTNVTLEMTGYFLPPQTGSYTFSFATVDDSAILSVGGSIAFECCAQEQPPITSTNFTINGIKPWDGSLPDNITGTVYMYAGYYYPLKVVYSNAVSWGTLPISVELPDGTTVSDNFEGYVYSFDDDLSQSNCTIPDPSIHTTSTITTTTEPWTGTFTSTSTEMTTITDTNGQLTDETVIVIRTPTTASTITTTTEPWTGTFTSTSTEMTTVTGTNGQPTDETVIVIRTPTSEGLITTTTEPWTGTFTSTSTEMTTVTGTNGQPTDETVIVIRTPTSEGLITTTTEPWTGTFTSTSTEVTTITGTNGQPTDETVIVIRTPTSEGLITTTTEPWTGTFTSTSTEMTTVTGTNGQPTDETVIVIRTPTSEGLISTTTEPWTGTFTSTSTEVTTITGTNGQPTDETVIVIRTPTSEGLITTTTEPWTGTFTSTSTEMTTVTGTNGQPTDETVIVIRTPTSEGLITRTTEPWTGTFTSTSTEVTTITGTNGQPTDETVIVIRTPTTAISSSLSSSSGQITSSITSSRPIITPFYPSNGTSVISSSVISSSVTSSLVTSSSFISSSVISSSTTTSTSIFSESSTSSVIPTSSSTSGSSESKTSSASSSSSSSSISSESPKSPTNSSSSLPPVTSATTGQETASSLPPATTTKTSEQTTLVTVTSCESHVCTESISSAIVSTATVTVSGVTTEYTTWCPISTTETTKQTKGTTEQTKGTTEQTTETTKQTTVVTISSCESDICSKTASPAIVSTSTATINGVTTEYTTWCPISTTESKQQTTLVTVTSCESGVCSETTSPAIVSTATATVNDVVTVYPTWRPQTTNEQSVSSKMNSATSETTTNTGAAETKTAVTSSLSRFNHAETQTASATDVIGHSSSVVSVSETGNTMSLTSSGLSTMSQQPRSTPASSMVGSSTASLEISTYAGSANSLLAGSGLSVFIASLLLAII
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
MDLLRSHLHKVRIPEPTNRIHKDECCVSFDTPRSEGGLYVDMVSFLGFGREYVEWNFEKTGNPVYLHIVQRRKPEPDEADRPLKKPTLLAIGVEGGFGDQEPEYDETFEIVILPDFICLPFPSVDLPEKVRLAVDKVLLAESADRKEQLAAWVADKKNISAYAMDLQQLDNGVIVPPTGWKCSKCDKTENLWLNLTDGMILCGRKLWDGSGGNNHAIEHYEQTKYPLAVKLGTITADLEAADVFSYPEDDSVEDPLLAQHLSHFGIDFSSLQKTEMTTAERELDANTNYDWNRIQESGKDAELLFGPGYTGLANLGNSCYMASIMQVMFSIHPFISRYFEKQSLKAAFATAPADPTVDLNMQLTKLAHGLLSGKYSAPAKEGQEGIRSRMFKSVITANHPEFSSMRQQDVLEFFLHLIDRVEKANPGDRELNPFSGFKFVVEERVQCPSGKVSYNKRSDNVLSLSIPLHEATNKEQLEAFNEKKAAMNLDGKEVSNEDIVRPRVPLEACLSSFSGPEEIPDFYSTALNSKTTVTKTAGFTTFPDYLVLHMRKFVMETGWVPKKLDVYIDVPDTIDITHMRSKGLQPGEELLPEGGSGDDSAEPANPVASEDIVTQLASMGFNYLHCQKAAINTSNTGVEEAMNWLLSHMDDPDINDPISKDSRAYEPSVDEASVQTLISFGFQEDIAIKALKASGGNIEKATDWIFSHPEASTSASADSSTSNVNADDTYIPDGSGRYKLMAFVSHMGTSTHCGHYVAHVLKDGRWTIFNDSKVAVSVDLPKEMGYLYFFQRISN
The following text describes a protein:
Function:
Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.
Sequence:
MPKCPKCNKEVYFAERVTSLGKDWHRPCLKCEKCGKTLTSGGHAEHEGKPYCNHPCYAAMFGPKGFGRGGAESHTFK
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAAAIPPITGMLRRGLVLDLSTAFGFGTTFGYLWWYGYHLPRVRARDAYYTRLEKERAAQQA
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
SSSSKSLGEAERLAALEQVCVAALDVGHISLAESCLDAMQAGASTSSVPKESARYRKLLGMCLEASGDFDGASAVYDALLKDNPSNRYAAKRKYCILAAQSGKEKEAMQALNDYLETNSGDIPAWNQMAEVCLSVSDFKGAAYCYEEVALGCPLDSTVHTKLGETYCTAGGIENAKLARKHLAQAVQLDSNNLRAWYGLI
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLLLLGGFLLLMLLGVPVAIAMAASSLLYILVSGVTPDVTLAQRMIAGVESFPLLAVPFFILAGNLMNIAGVTGRIYKFAVALVGWMRGGLGHVNIIGSVIFSGMSGTAIADAAGLGTIEIKAMKDHGYSTEFSVGVTAASATLGPIIPPSLPFVIYGMMANVSIGALFLGGVIPGIVMTLLMMATVTYFAHKNKWGSDTPFSWPQLGSAGLEIAIVLAFPLAIWLMVVAGMSTNMAVVIGLGVLLAIDWYFDFSAVMALMAPVILIGGMTLGWFTPTEAAVAAVIWSLFLGLVRYRTMTLKTVAKATFDTIETTASVLFIVTAASIFAWLLTVSQAAQMLSDWMLSITHNKWVFLALANVLILFVGCFIDTTAAITILVPILLPIVLKLGIDPIHFGLIMTLNLMIGLLHPPLGMVLFVLARVAKLSVERTTVAILPWLVPLMLALIAITYIPELTLWLPKYMGLSK
The following text describes a protein:
Function:
The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspE catalyzes the sulfur-transfer reaction from thiosulfate to cyanide, to form sulfite and thiocyanate. Also able to use dithiol (dithiothreitol) as an alternate sulfur acceptor. Also possesses a very low mercaptopyruvate sulfurtransferase activity.
Miscellaneous:
MISCELLANEOUS: Catalysis proceeds by a classical ping-pong bi-bi reaction mechanism, whereby a covalent enzyme-sulfur intermediate is formed on the active site cysteine.
Subcellular Localization:
Periplasm.
Sequence:
MFKKGLLALALVFSLPVFAAEHWIDVRVPEQYQQEHVQGAINIPLKEVKERIATAVPDKNDTVKVYCNAGRQSGQAKEILSEMGYTHVENAGGLKDIAMPKVKG
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKRAWMDRFIDTIEWIAAGFVGLVALDIFVSVLLRNTLNYSIPDSFDIGRMLLGILIFWGIAATSYRGTHITVDLVWGNVEPRYQRWIDVFATLVLLFVVTVQTWTLFDKVRGTYNDNVQTFDMHMPTWPFFAIAWIGDVSAVLLIAIRTYRLIFHPEEMHDPKLKATE
The following text describes a protein:
Function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Sequence:
MFHISRAVRCNALATAIAGRTSLSDAIRQVQKVWNLDFKDGPVITSTLAFNDEPDPAAPIFHVLDLQGRVFVEDKADSRAAAATPSTVNEAGKMESQSADVGEVFRYHAEDEMSVITREVAQGMMSAMLTHNTMDKIMLEAQRQGRISFYMTMFGEEAAVIGAAAGLASNDELFAQYREAGILTYRGYTIPEFIAQCMGNCECDAKGRQMPIHYGSKRLHAQMVSSPLATQIPHGAGAGYAFRLENQALERRLPAGTLLSTIPEARICATFFGEGAASEGDFHAGLNFASTVGSHTLFFVRNNGYAISTPTHSQYMGDGILSRAVGYGIPAARVDGLDALAVYHTVRKAREMILNSHRPVLVEALTYRLSHHSTSDDSTAYRSRDEIEHFAETFSPIERFEHFVTARGWWTPEQSREVVERTRSEVLSELRRQEKLPAWPVSTLCDDVFEHLTPELERQRTQLVEHYQAHRSIYDQEKL
The following text describes a protein:
Function:
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore.
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Sequence:
MNQEDLDPDSTTDVGDVTNTEEELIRECEEMWKDMEECQNKLSLIGTETLTDSNAQLSLLIMQVKCLTAELSQWQKKTPETIPLTEDVLITLGKEEFQKLRQDLEMVLSTKESKNEKLKEDLEREQRWLDEQQQIMESLNVLHSELKNKVETFSESRIFNELKTKMLNIKEYKEKLLSTLGEFLEDHFPLPDRSVKKKKKNIQESSVNLITLHEMLEILINRLFDVPHDPYVKISDSFWPPYVELLLRNGIALRHPEDPTRIRLEAFHQ
The following text describes a protein:
Function:
Regulates membrane-cell wall junctions and localized cell wall deposition. Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAKARRFVVLALRITTAAAAGVAAIVMATSHKTTTVFGVQVQAKFQYTPSFVFFVAANVVACAYSLLAILVPPASPAARHVLVADAVLGMVLTGAAAAAAAISALGKNGNSHAGWQPICGLVRTFCDHVTGALACGFVAVVLHLLVVLHSIYTMNT
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDHHKQLTLQTTLESCNNLYNLLFNSIGSIKPSQQQQQQQQNQKNTNSVTSNTNIINDQEIFKLNKFHLYGENNIDELYNSIELQLQTIKFTCQQYRQWDSTERDSIKFFNTQKLYNQSQQRGNLVSKTLFDCSLLGKIYLNQQKEQQQQQKQKNKQQQQQPQPLVEDLSKNISKTVEVKRKLGLLAGKLQEMTNELNNKYSTFSVLDDLLGLLKSNTEIDYNSDSYVSCNISSSTFLLDIDIYHNGEIKEVKLVHILTTTGEVEPAEQQFNDELTNSLKTDMKEFIKKVQRICDLDLLFRKYKHFDLQKAFSILQSDFLNISINSNIKYIDNKEIEMNKGFGEIKLDCCGVLIKYFQSYIEKISKMNEPYSIMIEMESSAVTNNGSLIDQSEYSRLSLKTLLQKQQHTQPSAQTDYSEQQQQQSISTQLTSIEFNEKDCLDCEPLSSMLESDSIFSPVRLVCKLNKPILITNQQLSKILNLSKIHRSSQQPSQQQPSQQQQQQQQQQQQKKLNSVDESMNENGDSNIIENINELIKKYSIQNLLISSSSSSSSSNDSNISVNVDNSFDCEVYGMKQRYYYTGEFELGIEISRIPIYHPSQVYPTIQLLRQQIVFNILFKSCFQNLNISKSDDHHNIIDNNNDVKIFEITSNPPNSINIIFLHPIDNSFNSIDIFIKNNGDLEAFYYDNTTNIQPNIQKSTLFTKMLIKSLSISVSLACFFKNK
The following text describes a protein:
Function:
Transcriptional regulator that positively regulates the expression of the yqhD-dkgA operon. Acts by binding directly to the promoter region of yqhD.
Sequence:
MLQNCAQSNCRIIPKKLRDMKREEICRLLADKVNKLKNKENSLSGLLPDVRLLYGETPFARTPVMYEPGIIILFSGHKIGYINERVFRYDANEYLLLTVPLPFECETYATSEVPLAGLRLNVDILQLQELLMDIGEDEHFQPSMAASGINSATLSEEILCAAERLLDVMERPLDARILGKQIIREILYYVLTGPCGGALLALVSRQTHFSLISRVLKRIENKYTENLSVEQLAAEANMSVSAFHHNFKSVTSTSPLQYLKNYRLHKARMMIIHDGMKASAAAMRVGYESASQFSREFKRYFGVTPGEDAARMRAMQGN
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Domain:
The homeodomain differs form the typical one by having namely 4 instead of 3 extra amino acids inserted in the loop between helix 1 and helix 2.
Sequence:
MQSTCVYRECMRNHAAKLGSYAIDGCREYSQPSTGDLCVACGCHRSYHRRIDVISSPQINHTRFPFTSLRRVKQLARLKWKTAEERNEEEEDDTEETSTEEKMTVQRRRKSKFTAEQREAMKDYAAKLGWTLKDKRALREEIRVFCEGIGVTRYHFKTWVNNNKKFYH
The following text describes a protein:
Function:
Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1.
Subcellular Localization:
Nucleus.
Sequence:
MEESHFNSNPYFWPSIPTVSGQIENTMFINKMKDQLLPEKGCGLAPPHYPTLLTVPASVSLSSGISMDTESKSEQLTPHSQASVTQNITVVPVPSTGLMTAGVSCSQRWRREGSQSRGPGLVITSPSGSLVTTASSAQTFPISTPMIVSALPPGSQALQVVPDLSKKVASTLTEEGGGGGGGGGTVAPPKPPRGRKKKRMLESGLPEMNDPYVLAPGDDDDHQKDGKTYRCRMCSLTFYSKSEMQIHSKSHTETKPHKCPHCSKTFANSSYLAQHIRIHSGAKPYSCNFCEKSFRQLSHLQQHTRIHSKMHTETIKPHKCPHCSKTFANTSYLAQHLRIHSGAKPYNCSYCQKAFRQLSHLQQHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHRRQHNKDKPFKCHNCHRAYTDAASLEAHLSTHTVKHAKVYTCTICSRAYTSETYLMKHMRKHNPPDLQQQVQAAAAAAAVAQAQAQAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQPPPPQPPHFQSPGAAPQGGGGGDSNQNPPPQCSFDLTPYKPAEHHKDICLTVTTSTIQVEHLASS
The following text describes a protein:
Function:
Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria. Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain. Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Plays an essential role in hematopoiesis; Acts as a co-chaperone in iron-sulfur cluster assembly in the cytoplasm. Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1. This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MEPTRAVLKCYASQWMRMVVQHWWSRKPPVSRGFWAFSWPPRLPCIKSATSAMSRSTLRSSCTYSLRSFCVTSQSRLCWRCQAEMSRAELFCPTCTSLQPPDESKDFFQVLDCEKSFNVDTQELQRKYRNLQRLLHPDFFSQKSESERNISEKQSTVVNKAYKTLLSPLKRGVYLLSLNGITLKEGADDEVDTQFLFDILELNEQLNDAETKDDIEEVGHFVQEQLVSLTKDLRKAFQQGDLQEAKILLAKMKYFSNIQDQVKKKIIP
The following text describes a protein:
Function:
Main transcriptional repressor of genes involved in N-acetylglucosamine (GlcNAc) transport and utilization. Represses the expression of the nagAB and nagP operons by binding directly within their upstream regions. Binds to the DNA consensus sequence 5'-ATTGGTATAGACAACT-3'. Also acts as a weak repressor of mapB expression.
Domain:
The N-terminal region contains a canonical wHTH DNA-binding domain. It is linked via a 21 residue-long linker to the C-terminal domain, which binds the effector molecule.
Sequence:
MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQFGISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGSRLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNESHFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNGTAFEHAKSVYRGDRYTFVHYMDRLS
The following text describes a protein:
Function:
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Prevacuolar compartment membrane; Multi-pass membrane protein. Note=Cycles between the Golgi apparatus and the prevacuolar compartment.
Sequence:
MITRWLLITSFLALAILSLSSAAKKSEPEITSSSFDNEPFSLSYFEDTETILMNTRDGNLFRSFDGGKAWEQVDGPDGKMKKAVRSIWQHPFDKNKAYALGANRRHWVTKDQAKTWESFEVDGYAAAQHEPLIFHGWDSAKVIFQSDECMGRLCIVKSYYTTDDFKTVSPLRVSAGGCLWAVGHPQFADGLNLEDELRDRVLCIVPGLKVPSAHANRLVYSDDFFRSDAEGTELNIQHGRPVSGILSAAAVKKFFVTAAKSQGTNELALYVTLDTKAWHRADFGGHRVEQDGYTLLESTNYSMQVDVLTSPSSNTGVLFTSNSNGTYFTRNVEHTNRDRFGHVDFEKIADIQGIVLVNTVKNWDKVESENEKKVVSSISFDDGRTFQSLKVGDKQLHLHSVTTFANTGRVFSSPAPGLVMGVGNTGDHLKKYSEGSLYVSDDAGVTWRHALDGPFKYEFGDQGSVIMAVSDKGTTDEIQFSIDHGKEWHSTKLQHKINPKLLTTTPDSTSLTFLLVGSEESSGTKHVVYSIDFHGLHERKCEKDDFEKWAARLNENGEPDCLMGHQQFFNRRKANADCFVDEEFKDPQPIFEPCKCSFEDFECDFNFVRSEDGKSCVPTAPLVPPVGRCQKQTDTFMGPSGWRLIPGNTCTREGGENLDKVVERPCKDVVSAPSHDKPMAQKQVFNDARQFSEQYYYLERQASSSGDDETVIMLTSEGEFWVSHDHGKNWEQPLKGVKIAAIVPHPYYSDGAFLLTRDKQAFWTVDRAYTFKSFEAPIPPNQEGLPVLSFHPHYKDWLIWTGAVDCSHGDCHSDAYFSKNRGENWDLLLRYVGKCEFESRENRPGSEKLIFCQQYENENKKNHLQLLSSENLFSDSHVHFNDAIRYATMSEYIIVASRDPDNPDSLIASVSVDGKTFARAEFPSNVDVPVKTAFTVLDSSTHAVFLHVTVSDVKGAEYGSIIKSNSNGTSYVLSLNAASRNEWGYVDFEKMQGLEGVAVVNIISNVDAVQKKGPAAKKLKTMITHNDGGQWMLLPPPAKDADGKNFGCSVKDGKGSDQCSLHLHGYTERRDPRDTFSSGSAIGLMMGIGNVGAYLSGKDEADTFMTRDGGITWKSVKKGRYMWEYGDAGSVIVIVPELRPTKVLYYSLDEGDNWEPYEFSEVEMHIYRLSTVPSDTSKNFLLWGKEMESNRLATINVDFSGLRKKSCILVEDGQESDDYYLWEPKHPFQEDNCLFGHVEQYHRKKPSSQCWNNWREPHVHSIGRNCTCTRADYECNYNYEPQNDGSCALVPGLPKPDALAVCREDPDRVEYWEPTAYRRIPQTTCSGGLILDHVVSKPCPSKEKEYEKKHGISGTGLFFAIMIPLVAAAGVGYYVYARWDGKFGQIRLGENAGTYEGLLSRESPIVTAPIAIIAGIVAVIRALPLLAMSLWRSASGYVRLGRNRAYSRPYASRGSFAARRGDYTSVVDDEDELLGVDDAEIDDDDEL
The following text describes a protein:
Function:
Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MATATRLLGWRVASWRMRPPPAGFVSQRAHSLLPVDDAINGLSEEQRQLRQTVAKFLQEHLAPKAQEIDRSNEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTCELIFEDCKVPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAKDCAGVILYSAECATQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFH
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May be involved in the detoxification of metabolites produced during cellular division and morphogenesis.
Sequence:
MADEAQAPPAEGAPPAEGEAPPPAEGAEGAVEGGEAAPPAEPAEPIKHSYTLFYFNVKALAEPLRYLFAYGNQEYEDVRVTRDEWPALKPTMPMGQMPVLEVDGKRVHQSISMARFLAKTVGLCGATPWEDLQIDIVVDTINDFRLKIAVVSYEPEDEIKEKKLVTLNAEVIPFYLEKLEQTVKDNDGHLALGKLTWADVYFAGITDYMNYMVKRDLLEPYPALRGVVDAVNALEPIKAWIEKRPVTEV
The following text describes a protein:
Function:
Transferase involved in the biosynthesis of the lipopolysaccharide (LPS). Catalyzes the transfer of a polymerized O-antigen molecule from its polyprenyl diphosphate membrane anchor to a terminal sugar of the lipid A-core oligosaccharide, finalizing the biosynthesis of the lipopolysaccharide. Required for the attachment of both A-band and B-band O-antigens, two forms of O-antigen produced by P.aeruginosa, onto the lipid A-core receptors. Important for cell wall integrity and motility of the bacteria.
Miscellaneous:
MISCELLANEOUS: Was originally reported to have ATPase activity, required for ligation as an energy source. However, it was shown later that ligation occurs without ATP and magnesium ions, and that WaaL cannot catalyze ATP hydrolysis in vitro.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MFAATRLSRLRHDTSRILSHWILPLGWLALLTGMFWVGDRSDYHRLFYILLAAPTLLYVILQPRLLRPLTGSPLFIAFLAFSSYMMLSLSWSTPENSTGSLLKRPLYIALLFFCAAILALEAPLRLKTATWLAALGAVISAAATLLRYYWDANPLRLTGYGALYNPLLSAHVYGAFTALWLAYWMQSRPILAPLPLISLALLGGLLIATGSRTPLVGLTAALMWLVLAGDRKKALIALALALAGALLGYILYPEVITQRGASFRPEIWADALRQISEHPWLGHGYDHPMRIVLSNGMLLADPHNIELGVLFAGGIIGLLLWVAIYALAFGFSWKNRKSPAVLLASTWLVFGLAAGLTEGNAFLPRPKEHWFLIWIPMALLYALWIQQRFAASRRGEDIAAP