lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Abrogates the interaction of BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).
Subcellular Localization:
Nucleus. Nucleus, PML body. Note=Co-localizes with the CLOCK-BMAL1 heterodimer in the PML body.
Sequence:
MDSPSSVSSYSSYSLSSSFPTSPVNSDFGFPSDSEREDKGAHGPRPDTVGQRGGSRPSPGPIRCRHRSKVSGNQHTPSHPKQRGSASPMAGSGAKRSRDGELETSLNTQGCTTEGDLLFAQKCKELQGFIPPLTDLLNGLKMGRFERGLSSFQQSVAMDRIQRIVGVLQKPQMGERYLGTLLQVEGMLKTWFPQIAAQKSSLGGGKHQLTKHFPSHHSDSAASSPASPMEKMDQTQLGHLALKPKQPWHLTQWPAMNLTWIHTTPICNPPLSSPGTISFSHGPLGTGTGIGVILFLQHGVQPFTHSAPTTPVPPTTASPVIPGEPMKLSGEGPRCYSLPVTLPSDWSYTLSPPSLPTLARKMTIGHREQQRSHPPVAADAHLLNL
The following text describes a protein:
Function:
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
RRMDGWYNNLDHPQWGSPGERMIRRSTNGYSNGINKPIEDGLPNPHTLSRLLMRGESGIPSVTGKSVFLAFFGQHVGDDMIDSRRNACPSEYINIEIEENKESNNHILPMYRSKFITGSGSSVNSPRMLVNEATSWLDGSVIYGNSHSWSEHLRSFERGRLKEEDGHPGYPSFNRNEIPLYNPTIDLKRPPKTRNPEELLSFGNPRGNENPFLMTIEIIWFRWHNHLAEKIAVQNPDWSDQQIFDKARKWTIATYQNIAFYEWLPEIIGTSPPPYRETEYNKFMLPSVSVEFSIAAMRLGHSLVPSGVVLRQPDCSPIDPLPEDYLASAGEPALRLCNTYWQLQDALLDLGIEGIVLGMTSQNAEEEDAVVVDDLAGFLYGPLKRTRMDLEAMTIQRGRDAGLQRYNEVRKTYDLPPITDFSQLNPSLPNEVIARLRNAYNNDTNKLELYVAGMMEDRSNASNVLFYKIILEQFQRTRDGDRLWFENAQNGLFNASELQEIRQTTMRDIIAATTTFNRSLFQPNVFNTAGNKSCTPNTGIDFFYGYWGKYAGIVVLLLLFPFGKCCYLTSEYNAYLFMMVLYRGDVKKSTVGTGFNNRLCTHKISKWVLIFFLAFEVEGQDKSRRVVVMLEGTCIKLFSSAGRELRKICFSHFKVNECSLLYPCTATFQKSFLFMSRNKRNHVCFRVEAIKNVQEFMQHNGVNVDVFEMDESALKEEAVTKEARQALLETFLRQTFAEALNIDDAVEQNSKAKYRHKTMEVADCELTQMELAETMGMKPDSLFVTQMFQLADTDHSGYLSFREFADLIILLMNGSPEQKAKMLFDMYDVDHSGEINREEGRNMIKSFLEMAGANLGPDEVSAAVSTIFKEAGIGENKDSLTLEDFTYVLLKDHREAFESSELSMPGRSNLYKDQGELSEQNKMSDQSINCNTFTGITKSLKKNVENYRRHIFCMVIFYGITIALLVERATLHAYGAQHIGIRRVTEWGIIISRASAAAISFHFRSILLTMSRNLIATCRETLLKNLIPFDSAVAFHKQIAYVALVETIFHVLGHASNFYHFCVHPLPVLACLFPKIFVDDGSDLPKSLTWWFFETITGLTGVLLLLTISIIYVFAMQYSRRFCFRAFWITHHL
The following text describes a protein:
Function:
Plays a role in both early and late gene expression.
Subcellular Localization:
Host nucleus. Note=Enters the host nucleus and accumulates within the electron-dense regions of the virogenic stroma.
Sequence:
MVNVPEQQSPETAAVCKNEKLLNKLESSSYNKSNMDQLAVIVNFLERKNINYILNVVPVMQDERKMSKRKKKVINNNKYILFNSWYTKIKQPEWPSSPAMWDLVKNKPELADFVFIFDHTEKLGKKMADRSTSSSSSENAAIPASKKRQTVVLTNANLAELKESCEMRDKLYSEFYSLLNETFNHNVAPLLSNIYDEVLTRDFITKSMAKFKTVALKLPVAPSTTEYVPTPISGSRKRKSSVPAKQRSSIKTRRNTVAPALLMVSDNTQDTNMSD
The following text describes a protein:
Function:
Repressor of the multidrug resistance operon mdtRP. Acts by binding directly to the mdtRP promoter region, leading to the repression of its expression.
Subcellular Localization:
Cytoplasm.
Sequence:
MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLASLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGDIKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG
The following text describes a protein:
Function:
Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MDIGGPTNIRHVAHVTFDRFDGFLGLPSEFEPDVPRKAPSASATVFGVSTESMQLSYDSRGNCVPVILLLLQSRLYDQGGLQAEGVFRITGENSEEEFVREQLNKGIIPDGIDVHCLAGLIKAWFRELPRGVLDPLPSEQVMQCESDEDFVKVVRLLPQTEASLLNWAINLMADVIQFEHVNKMNSRNLALVFAPNMSQMADPLTALMYAVQVMKLLKSLTEKTVREREASSSVVDRRCSKEAEDGEKEKDNEEEEEDEEEEEEEEDEDEDEEEEGDGVYIIKEEEASEIIKVVADEHKSGSIKSEFEGSSATDSKGDNGVVQPPICSSNP
The following text describes a protein:
Function:
Putative transcription factor that appears to regulate lipid metabolism.
Subcellular Localization:
Nucleus.
Sequence:
MPQQLLITLPTEASTWVKLQHPKKAVEGAPLWEDVTKMFEGEALLSQDAEDVKTQRESLEDEVTPGLPTAESQELLTFKDISIDFTQEEWGQLAPAHQNLYREVMLENYSNLVSVGYQLSKPSVISQLEKGEEPWMAEKEGPGDPSSDLKSKIETIESTAKSTISQERLYHGIMMESFMRDDIIYSTLRKVSTYDDVLERHQETCMRDVRQAILTHKKRVQETNKFGENIIVHSNVIIEQRHHKYDTPTKRNTYKLDLINHPTSYIRTKTYECNICEKIFKQPIHLTEHMRIHTGEKPFRCKECGRAFSQSASLSTHQRIHTGEKPFECEECGKAFRHRSSLNQHHRTHTGEKPYVCDKCQKAFSQNISLVQHLRTHSGEKPFTCNECGKTFRQIRHLSEHIRIHTGEKPYACTACCKTFSHRAYLTHHQRIHTGERPYKCKECGKAFRQRIHLSNHKTVHTGVKAYECNRCGKAYRHDSSFKKHQRHHTGEKPYECNECGKAFSYNSSLSRHHEIHRRNAFRNKV
The following text describes a protein:
Function:
Specific and potent inhibitor for yeast aspartic protease A (yscA). The proteinase acts as a folding template stabilizing the helical conformation in the inhibitor, which results in the potent and specific blockage of the proteolytic activity.
Sequence:
MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQDKDGKTTDADESEKHNYQEQYNKLKGAGHKKE
The following text describes a protein:
Function:
Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
Sequence:
MGVLESYQKIYEELQQLRSENPPTLIAVSKFQPIEKIKEAIGCGVVHFGENRIQEGIEKFSQWLKDKNTSLVLHHIGPVQSGTLRKLFLGYSYAHGVGSVGIVNELLTRALREEKKILYFLQANLTGENTKHGFERKELIEILKQKEKLSNTYCKLEGLMVMGPSDGDLTKTREVFRELSKFKKDYIPEAKLSMGMSGDYKIAIEEGSDFVRIGSAIFGERN
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity); Plays a critical role in M.tuberculosis ability to inhibit apoptosis of infected macrophages; thus helps the bacterium in its struggle to resist the host immune response. In fact, via a NuoG-dependent mechanism, M.tuberculosis can neutralize NOX2-derived reactive oxygen species (ROS) in order to inhibit TNF-alpha-mediated host cell apoptosis. Also mediates inhibition of neutrophil apoptosis, leading to delayed activation of naive CD4 T cells.
Sequence:
MTQAADTDIRVGQPEMVTLTIDGVEISVPKGTLVIRAAELMGIQIPRFCDHPLLEPVGACRQCLVEVEGQRKPLASCTTVATDDMVVRTQLTSEIADKAQHGVMELLLINHPLDCPMCDKGGECPLQNQAMSNGRTDSRFTEAKRTFAKPINISAQVLLDRERCILCARCTRFSDQIAGDPFIDMQERGALQQVGIYADEPFESYFSGNTVQICPVGALTGTAYRFRARPFDLVSSPSVCEHCASGCAQRTDHRRGKVLRRLAGDDPEVNEEWNCDKGRWAFTYATQPDVITTPLIRDGGDPKGALVPTSWSHAMAVAAQGLAAARGRTGVLVGGRVTWEDAYAYAKFARITLGTNDIDFRARPHSAEEADFLAARIAGRHMAVSYADLESAPVVLLVGFEPEDESPIVFLRLRKAARRHRVPVYTIAPFATGGLHKMSGRLIKTVPGGEPAALDDLATGAVGDLLATPGAVIIVGERLATVPGGLSAAARLADTTGARLAWVPRRAGERGALEAGALPTLLPGGRPLADEVARAQVCAAWHIAELPAAAGRDADGILAAAADETLAALLVGGIEPADFADPDAVLAALDATGFVVSLELRHSTVTERADVVFPVAPTTQKAGAFVNWEGRYRTFEPALRGSTLQAGQSDHRVLDALADDMGVHLGVPTVEAAREELAALGIWDGKHAAGPHIAATGPTQPEAGEAILTGWRMLLDEGRLQDGEPYLAGTARTPVVRLSPDTAAEIGAADGEAVTVSTSRGSITLPCSVTDMPDRVVWLPLNSAGSTVHRQLRVTIGSIVKIGAGS
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MGKIAKGSRKGKKAWRANISTEDIEDFFEQSNKDALSGGSLSQLPNDSLFYVDNSKDLSVKRKIEKHREKVLRCDSVLQKNPFVQALPSSKPKQKKKSKKENKDVVKEKDETRDGQKSDGASASGMVDIWANEGEGDNPKKVPKPSVIPAVEVEASGCSYNPTFESHQESLAQAVAEEMQKVYRKELGPEPVPITVPGEVINDEDRYFLEVDNGSDDENVENLSENQDTGNENRSRKTKKVTRVELNKRERHKELHRKEAEAKKREELSKQIDSLPNIIEEITKEDEEKQKRHIRRVVAMQERLKVRPPRLGKHKFEPAPTQVLLSEEITGSLRKLKGCCTLVKDRFKSLEKRGLIVPVKGKRLDELSTLLLLFLSLVVAILLIRVTVDYLKQRL
The following text describes a protein:
Function:
Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome (By similarity). In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented (By similarity). PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2: specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination.
Subcellular Localization:
Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies.
Sequence:
MAAVEAETGLLTLESLPTDPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRRHCKKYWLISEEEKAGKSQCWRSLFIETYSDVGRYIDHYAAIKKAWRDLKKYLEPRCPRMVLSLKEGAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPGLLGSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLTFCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPAAIDMFIIGATFTDWFTSYVNNVVSGGFPIIRDQIFRYIHDPECVATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIEMSRDALPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPGRIYEYTSCTTFSTTSGYMEGYYTFHFLYFKDKVFNVAIPRFHMACPTFRVSIARLEMGPDEYEEMEEEAEEEEEEENDDSADMDESDESDADENESDEGEGEARRRRVFDVPIRRRRCSRLF
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSPPVKVIGHIASPFSHRVEAALCLKGVPYELIQEDLFNKSELLLTHNPVHKKVPVLLHGDRAICESLVIVEYVDEAFEGPPLLPIDSYDRAMARFWADFMDNKLLKLFWLAHWTEGEVQKGITKEAKESLALLEDKLRGNRFFGGDTVSYLDLVYCWLAPWLSVVEEVTGVTVVDESEFPAIRQWEKEYNSCEALKPCMPDRDQIVAYFIESKESYKMFANAWAAQQ
The following text describes a protein:
Function:
May be involved in the ribosome maturation process.
Subcellular Localization:
Nucleus, nucleolus. Note=Found in the dense fibrillar compartment region of the nucleolus.
Sequence:
MVWTSRICFRKYGNFVDNVRLYVRGGTGGMGLPRLGGHGGDGGDVWVVAKKDTRLKQIKDKHPDKRFIAGVGSNSSIQALRGAKGEDVEVFAPTGISVTSDHGRMLGELNREGDKLLVAKGGRGGSPQSGFLPNKGQTRNIRLDLKLIADFGLVGFPNAGKSSLLTALSHAKPKIANYPFTTIKPEIGKVMYDDHKQVSVADLPGLIEGAHVNKGMGHKFLKHVERTKQLMFVVDVCGFQLASKTPFRSAFETVLLLSKELELYKEELLSKPAILVINKMDLPEAQSHFQELEAQLENQGESIHLFSEDVIPKSLMHFTHIVPVSAMTGHGLPLLKSLIRQSLEEQDTIDTEAQRSQKILELRREIPSSSIPSWGLPQPT
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MAEYDDAYEDEFYDEMEEGITSEDCWTVISSFFDTKGLVSQQLDSFDEFISSTMQELVEEQGQVTLDQTLPPSEDEDDPVVLRRYELKFGTVMLSRPSVTEGDGATTIMLPQEARLRNLTYASPLYLGITKRIMEGRERLIADRDEDDAAPDADEDRKARGTYLQWEQKELPPDQAKEETVFIGKMPIMLKSKYCILKDLSEQALYNWNECPYDSGGYFIINGSEKVLIAQERSAGNTVQVFKKAPPSPTPYVAEIRSAVEKGSRLLSQLSLKLFAKGDSAKGGFGPTIRSTLPYVKTDIPIVVVFRALGVVSDEDILNHICYDRNDTPMLEMLKPCIEEGFVIQDREVALDFIAKRGSSQSSMNHERRVRYAREIMQKELLPHISQSEGSETRKAFFLGYMVHRLLQCALGRRDVDDRDHFGKKRLDLAGPLLANLFRVLFTRVTRDLQRYVQRCVETNREIYLNIGIKASTLTGGLKYALATGNWGEQKKAASSKAGVSQVLSRYTYASTLSHLRRTNTPIGRDGKIAKPRQLHNTHWGLVCPAETPEGQACGLVKNLALMCYITVGTPSEPIIDFMIQRNMEVLEEFEPQVTPNATKVFVNGVWVGVHRDPAHLVNTMLSLRRRNMISHEVSLIRDIREREFKIFTDAGRVCRPLFVVDNDPKSENCGSLVLNKDHIRKLEQDKELPADLDPEDRRERYFGWDGLVKSGVVEYVDAEEEETIMIVMTPEDLEISKQLQAGYALPEEDDPNKRVRSVLSQKAHTWTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNFDQRMETMANILYYPQKPLATTRSMEFLRFRELPAGQNAIVAIACYSGYNQEDSVIMNQSSIDRGLFRSLFYRTYTDSEKMVGLTVVERFEKPMRSDTIGMRKGTYDKLDEDGIIAPGVRVSGEDIIIGKTAPLAPEAEELGQRTKAHTKLDVSTPLRSTENGIVDQVLVSTSNDDLKFVKVRMRTTKIPQIGDKFASRHGQKGTIGITYRQEDMPFTREGVSPDLIINPHAIPSRMTIAHLIECQLSKVSALRGFEGDATPFTDVTVDSISRLLREHGYQSRGFEVMYNGHTGRKLVAQVFLGPTYYQRLRHMVDDKIHARARGPTQILTRQPVEGRARDGGLRFGEMERDCMIAHGASAFLKERLFDVSDPFRVHICDDCGLMTPIAKLKKGLFECRLCNNKHRISQVHIPYAAKLLFQELAAMNIAARMFTNRSGVSVR
The following text describes a protein:
Function:
Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.
Sequence:
MSSHCAETSPNNNSVPESQSNTTRSDAQAQNSNIFIENRVIESAEFISQNSKHVKLGTDDEYKKAAVIVEDLAKKWRAESWSDFPLHPSELSDPEKKAAYVFLIDTMNYAFWTETGHKPYTVSYNGKPYTGYWSLCAAIKNAVLKDEKILDAEFWAKATVEDWGKIFTSETETPCPFLEWRQKTISEAGRYLINNFEGSTYKMIKSCNKSAVALAELVRANLDSYKDQYEYHGRTVYFLKRAQIFAADLYFAFAADNNYVAEACSFTDINKLTMFADYRVPQALNYLNLIHYDDYLMNELKERPHFPPGSELECEIRGCSIAAVEKLKKFISYPKITSVLIDFVLWPYAKENTELMAHIPIHQTRSVFY
The following text describes a protein:
Function:
Vacuolar Fe(2+) uptake transporter.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Domain:
The cytoplasmic metal binding domain (MBD) is located between transmembrane 2 (TM2) and transmembrane 3 (TM3).
Sequence:
MAGNGDEHRLNLEPEKQSLLNRHTEKHFTAGEIVRDIIIGVSDGLTVPFALAAGLSGANATSSIVLTAGIAEVAAGAISMGLGGYLAAKGEADHYNRELKREQEEIVTVPETEAAEVAEILAEYGIEAHEYGPVVNALRKNPQAWLDFMMKFELGLEKPDPRRALYSAMTIAIAYVLGGIVPLIPYMFIRNASEAVLVSVVVTLIALLIFGFVKGSFTGNKPIRSALETALIGAIASAAAYGLAKAFHP
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MKSPVFPYASEMSCFWFIFMLFFVISPINDVSPAQLTVNGPLHPVTASLSEDIVLHCHLSPRTSAENMEIKWFRSQNSSYVHLYHNGKEHLEKQQPEYQGRTELLTDGIEDGKIGLRILNVSFYDAGQYHCSVKNKSFHQEATLDIKVAALGSTPLISIERYQERGIYLVCRSRGWYPQPEVLWRNPSGKHLSFLAKETSQENNGLFEVQKDILLTEGSNQPLTCVVRNRLLNQEKGSTIHVADNFFPKIDPWAVGLCVSILVPVGLLIAILYLINRNRKLITELSWRNMVVPIEKANVTLDPSTANKELILSADQKNVIQGFMWHNLPDHPWRFDVERCILGKEGFSSGRHYWEVEVGEEGYWAVGVARESVRRKGRLSLDPDEGIWAVEKARVQTVQYQALTIPQTPLTLRKRPRKVGIYLDYELGKVAFHDVNHKMHIFTFFAADFNGETIFPFLQVGIGCWLTVCP
The following text describes a protein:
Function:
Essential for normal spermatogenesis and male fertility (By similarity). Required for the completion of meiosis in male germ cells (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly localized to the cytoplasm. Translocates from the cytoplasm to the nucleus in the G2/M transition upon treatment with cadmium, cobalt or zinc.
Sequence:
MEEGPLPGGLPSPEDAMVTELLSPEGPFASENIGLKAPVKYEEDEFHVFKEAYLGPADPKEPVLHAFNPALGADCKGQVKAKLAGGDSDGGELLGEYPGIPELSALEDVALLQAPQPPACNVHFLSSLLPAHRSPAVLPLGAWVLEGASHPGVRMIPVEIKEAGGTTTSNNPEEATLQNLLAQESCCKFPSSQELEDASCCSLKKDSNPMVICQLKGGTQMLCIDNSRTRELKALHLVPQYQDQNNYLQSDVPKPMTALVGRFLPASTKLNLITQQLEGALPSVVNGSAFPSGSTLPGPPKITLAGYCDCFASGDFCNNCNCNNCCNNLHHDIERFKAIKACLGRNPEAFQPKIGKGQLGNVKPQHNKGCNCRRSGCLKNYCECYEAQIMCSSICKCIGCKNYEESPERKTLMSMPNYMQTGGLEGSHYLPPTKFSGLPRFSHDRRPSSCISWEVVEATCACLLAQGEEAEKEHCSKCLAEQMILEEFGRCLSQILHTEFKSKGLKME
The following text describes a protein:
Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MANKSKFIDYIDEALEKSKETALSHLFFTYQGIPYPITMCTSETFKALDTFEARSDDIVLASYPKCGSNWILHIISELIFAESKKKYEYPEFPILECGDPEKYQRMKQFPSPRILATHLHYDKLPGSIFKNKAKILVIFRNPKDTAVSFFHFHNDVPDIPSYGSWDEFFRQFMKGQVSWGSYFDFAINWNKHLDDENIKFILYEDLKKNLAAGIQQIADFLGFSLTGEQIQTITAQSTFQAMRAKSQETHGAVGPFLFRKGEVGDWKNLFSETQNQEMDAKFKECLTGTSLGAKLKYESYCQA
The following text describes a protein:
Function:
Electron transport system for the ribonucleotide reductase system NrdEF.
Sequence:
MSITIYTRNNCVQCHATKRAMESRGFEFEMVNVDLVPDAADTLRAQGFRQLPVVMAGDLSWSGFRPDMINRLHPTPHAANA
The following text describes a protein:
Function:
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
Subcellular Localization:
Secreted.
Sequence:
MWVLVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRSNSVILLGRHNPYYPEDTGQVFQVSHSFPHPLYNMSLLKNRYLGPGDDSSHDLMLLRLSEPAEITDAVQVLDLPTWEPELGTTCYASGWGSIEPEEHLTPKKLQCVDLHIISNDVCAQVHSQKVTKFMLCAGSWMGGKSTCSGDSGGPLVCDGVLQGITSWGSQPCALPRRPSLYTKVVRYRKWIQDTIMANP
The following text describes a protein:
Function:
Sodium-independent transporter of chloride and iodide (By similarity). Mediates electroneutral iodide-chloride, iodide-bicarbonate and chloride-bicarbonate exchange with 1:1 stoichiometry. Mediates elctroneutral chloride-formate exchange (By similarity).
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney.
Sequence:
MAARGGRSEPPQLAEYSCSYTVSRPVYSELAFQQQRERRLPERRTLRDSLARSCSCSRKRAFGVVKTLLPILDWLPKYRVKEWLLSDIISGVSTGLVGTLQGMAYALLAAVPVQFGLYSAFFPILTYFVFGTSRHISVGPFPVVSLMVGSVVLSMAPDDHFLVPSGNGSALNSTTLDTGTRDAARVLLASTLTLLVGIIQLVFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGILSIIYTLIEIFQNIGDTNIADFIAGLLTIIVCMAVKELNDRFKHRIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPSGFLPPVLPSVGLFSDMLAASFSIAVVAYAIAVSVGKVYATKHDYVIDGNQEFIAFGISNVFSGFFSCFVATTALSRTAVQESTGGKTQVAGLISAVIVMVAIVALGRLLEPLQKSVLAAVVIANLKGMFMQVCDVPRLWKQNKTDAVIWVFTCIMSIILGLDLGLLAGLLFALLTVVLRVQFPSWNGLGSVPSTDIYKSITHYKNLEEPEGVKILRFSSPIFYGNVDGFKKCINSTVGFDAIRVYNKRLKALRRIQKLIKKGQLRATKNGIISDIGSSNNAFEPDEDVEEPEELNIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAVSFLDVVGVRSLRMIVKEFQRIDVNVYFALLQDDVLEKMEQCGFFDDNIRKDRFFLTVHDAILHLQNQVKSREGQDSLLETVARIRDCKDPLDLMEAEMNAEELDVQDEAMRRLAS
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The Cas1-Cas2 complex is involved in CRISPR adaptation, the first stage of CRISPR immunity, being required for the addition/removal of CRISPR spacers at the leader end of the CRISPR locus. The Cas1-Cas2 complex introduces staggered nicks into both strands of the CRISPR array near the leader repeat and joins the 5'-ends of the repeat strands with the 3'-ends of the new spacer sequence. Spacer DNA integration requires supercoiled target DNA and 3'-OH ends on the inserted (spacer) DNA and probably initiates with a nucleophilic attack of the C 3'-OH end of the protospacer on the minus strand of the first repeat sequence. Expression of Cas1-Cas2 in a strain lacking both genes permits spacer acquisition. Cas2 not seen to bind DNA alone; the Cas1-Cas2 complex preferentially binds CRISPR-locus DNA. Highest binding is seen to a dual forked DNA complex with 3'-overhangs and a protospacer-adjacent motif-complement specifically positioned. The protospacer DNA lies across a flat surface extending from 1 Cas1 dimer, across the Cas2 dimer and contacting the other Cas1 dimer; the 23 bp-long ds section of the DNA is bracketed by 1 Tyr-22 from each of the Cas1 dimers. Cas1 cuts within the 3'-overhang, to generate a 33-nucleotide DNA that is probably incorporated into the CRISPR leader by a cut-and-paste mechanism. This subunit's probable nuclease activity is not required for spacer acquisition.
Domain:
Substrate DNA-binding induces large structural changes that generate a surface for DNA-binding across the Cas2 dimer and formation of an optimal catalytic site.
Sequence:
MSMLVVVTENVPPRLRGRLAIWLLEVRAGVYVGDVSAKIREMIWEQIAGLAEEGNVVMAWATNTETGFEFQTFGLNRRTPVDLDGLRLVSFLPV
The following text describes a protein:
Function:
Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.
Subcellular Localization:
Nucleus.
Domain:
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MPTRVLTMSARLGPLPQPPAAQDEPVFAQLKPVLGAANPARDAALFSGDDLKHAHHHPPAPPPAAGPRLPSEELVQTRCEMEKYLTPQLPPVPIISEHKKYRRDSASVVDQFFTDTEGIPYSINMNVFLPDITHLRTGLYKSQRPCVTQIKTEPVTIFSHQSESTAPPPPPAPTQALPEFTSIFSSHQTTAPPQEVNNIFIKQELPIPDLHLSVPSQQGHLYQLLNTPDLDMPSSTNQTAVMDTLNVSMAGLNPHPSAVPQTSMKQFQGMPPCTYTMPSQFLPQQATYFPPSPPSSEPGSPDRQAEMLQNLTPPPSYAATIASKLAIHNPNLPATLPVNSPTLPPVRYNRRSNPDLEKRRIHFCDYNGCTKVYTKSSHLKAHLRTHTGEKPYKCTWEGCDWRFARSDELTRHYRKHTGAKPFQCMVCQRSFSRSDHLALHMKRHQN
The following text describes a protein:
Function:
Part of the tripartite efflux system PvdRT-OpmQ required for the secretion into the extracellular milieu of the siderophore pyoverdine (PVD), which is involved in iron acquisition. This subunit is an adapter protein that stimulates the ATPase activity of PvdT and connects the inner and outer membrane components (By similarity). The system is responsible for export of newly synthesized PVD after the final steps of biosynthesis have taken place in the periplasm. It is also responsible for recycling of PVD after internalization of ferri-PVD into the periplasm by the outer-membrane receptor FpvA and release of iron from PVD, thus making PVD available for new cycles of iron uptake. In addition, can expel unwanted metals complexed with PVD from the periplasm into the extracellular medium. Does not contribute to resistance to antibiotics belonging to the classes of tetracyclines, aminoglycosides, beta-lactams and macrolides, and chloramphenicol.
Miscellaneous:
MISCELLANEOUS: Was originally thought to be involved only in PVD recycling. It was later shown to be involved in the secretion of both newly synthesized PVD and recycled PVD.
Subcellular Localization:
Periplasm.
Sequence:
MRRTRSTRRALLVAVCLSPLIALAAWQAYPFRSNNFDTVSVSRGSIESSVSALGTLQPRRYVDVGAQASGQIRKLHVEAGDDVTEGQLLVEIDPSTQQAKVDAGRYSIEMLKAQLAEQRAQYTLARQQYQRQQRLAAGGATRTEDVQSAQAQMLATQARIEMYQAQIRQAQASLRSDEAELGYTRIYAPMSGTVVAVDAREGQTLNAQQQTPLILRIAKLSPMTVWAQVSEADIGRVKPGMPAYFTTLSGEGRRWTGKVRQILPVPPKPLDQSNQGGGSPTSGSGGQSGSGRVVLYTVLVDVDNGDHQLMAEMTAQVFFVAATAENILTAPVAAIHDDGKGGQVAWVVGSNGKPQSRQIRTGISDRLRVQVLAGLEEGDRLLMAAPDGSDS
The following text describes a protein:
Function:
Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner.
Subcellular Localization:
Nucleus.
Sequence:
MVAPVLKSFQAEVVALSKRSREAEAAFLSVYKQLIEAPDPVPSFEVARTLDDRLQRPSFDPSGQRLQDVHIAWKRCPEPPSAREQNEGTCPTGHTPANGNHLPGPEDTLVTDTLLQKNEAERQKGLQEVHITLAARLGEAEEKIKVLHSALKATQTELLELRRKYDEEAASKADEVGLIMTNLEKANQRAEAAQREVESLREQLASVNSSIRLACCSPQGPSGEKVSFALCSGPRLEAALASKDREILRLLKDAQQLRHSLQELEEVSANQIADLERQLAAKSEAIEKLQEKLEAQADYEEIKTELSILRAMKLASSTCSLPQTLAKPDDPLLVAKDVFFPTQKFLLEKPALLASPEEDPSEDDSIKGSLGTEPPYPPQLPPPPGPEDPLSPSPAQPLLGPSLGPDGPRTFSLSPFPSLAPGERLAGDSLLSKHMMGPAAFKGETGNLLAFPPTFYGGAKPPSAPAASVPCPEPTGAPEAVDGAGPEEEQLDTAEIAFQVKEQLLKHNIGQRVFGHYVLGLSQGSVSEILARPKPWRKLTVKGKEPFIKMKQFLSDEQNVLALRTIQVRQRGSITPRIRTPETGSDDAIKSILEQAKKEIESQKGGESKNSPASVSIPNGTASSSTSEDAIKNILEQARREMQAQQQALLEMESGPRGRSVPPSPPERPSPATASQNGALTCVKQEDGGGGSGSSSTVQAPLAVLSPAAFVQRIIRKVKSEIGDAGYFDHHWASDRGLLSRPYASVSPSLSSSSSYSGQPNGRAWPRGDEATIAPEDEAAMGEDEAPRVGELKAEAGAPEVGGGRLPYYPAYVPRTLKPTVPPLTPEQYELYMYREVDTLELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLSDQLGQGQGQAPTQQPSASQASPTEPTSSPSPPPSPTEPEKTSQEPLGLSLESSKENQQPEGRASSSLGGKPFSSSQAAGGIQEMVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLSDPHNVEKLRDMKKLEKKAYLKRRYGLIGTGSDSESPAAHSECPSPCLQPQELSLMQAKKPRVVLAPAEKEALRKAYQLEPYPSQQTIELLSFQLNLKTNTVINWFHNYRSRMRREMLVEGTQDDPDFDPSGGPNVLTPGHTHREPTPQSPDSETEDQKPPMKSLELQEPEGPLQRAAPDRALVKIKQEEGLEVDGDSQPQDVGDPDRGQDGPKEEHTHPLGNSDLSELAPGPFLSGTPNPDCPSLHNPQEKGTGEQVHSEPLSFKSTSESSCCSLEGPPNSPSVISSPDLTTCVSPAPSSSAPISPSLPGAPPAKVPSTSPTGDTAAALHPSTKVNPNLQRRHEKMANLNSIIYRLERAANREEVLEWEF
The following text describes a protein:
Function:
Binds together with bS18 to 16S ribosomal RNA.
Sequence:
MNNFYEKVVLLLPTLTEEEVQEAVKKISSLIVENGGEILKVDNWGKKKLAYKLNRQTMGYYVLFLFKAPALSIKKMEEFYKVYDPVFKFMVFKLTKHQIAALPPEIKGIPVEPSEIASQG