lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTDK-I phosphorylates 'Ser-5' if the CTD substrate is not phosphorylated at 'Ser-5', but will phosphorylate 'Ser-2' of a CTD substrate if 'Ser-5' is already phosphorylated. CTDK-I is also more reactive toward substrates that are prephosphorylated at 'Ser-2' or 'Ser-5' compared with an unphosphorylated CTD substrate, therefore efficiently creating doubly phosphorylated CTD repeats. Involved in RNA polymerase II transcriptional elongation, and through PTI1, pre-mRNA 3'-end processing. Participates in both positive and negative regulation of CTD phosphorylation. Required for DNA damage induced transcription, including the expression of the RNR genes, and reprogramming of gene expression upon amino acid starvation. Required for SET2 mediated H3K36 methylation. Also regulates H3K4 methylation. Controls the maintenance of suppressive chromatin in the coding regions of genes by both promoting H3K36 methylation, which leads to histone deacetylation, and catalyzing phosphorylation of the CTD required to localize H3K4 chromatin modification specifically to the 5' ends of genes, thereby creating a boundary for H3K4 methylation that prevents a mark associated with transcriptional initiation from spreading into the bodies of genes. Involved in RNA polymerase I transcription. Involved in telomere maintenance. Acts together with SNF1 to induce GSY2 transcription in response to glucose limitation. Involved in the adaptation to alternative carbon sources, including galactose, glycerol and ethanol, but not raffinose. Required for the integrity of the rDNA locus. Functions in translation elongation by enhancing decoding fidelity. Needed for translational accuracy by phosphorylating RPS2.
Miscellaneous:
MISCELLANEOUS: Present with 125 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm.
Sequence:
MSYNNGNTYSKSYSRNNKRPLFGKRSPNPQSLARPPPPKRIRTDSGYQSNMDNISSHRVNSNDQPGHTKSRGNNNLSRYNDTSFQTSSRYQGSRYNNNNTSYENRPKSIKRDETKAEFLSHLPKGPKSVEKSRYNNSSNTSNDIKNGYHASKYYNHKGQEGRSVIAKKVPVSVLTQQRSTSVYLRIMQVGEGTYGKVYKAKNTNTEKLVALKKLRLQGEREGFPITSIREIKLLQSFDHPNVSTIKEIMVESQKTVYMIFEYADNDLSGLLLNKEVQISHSQCKHLFKQLLLGMEYLHDNKILHRDVKGSNILIDNQGNLKITDFGLARKMNSRADYTNRVITLWYRPPELLLGTTNYGTEVDMWGCGCLLVELFNKTAIFQGSNELEQIESIFKIMGTPTINSWPTLYDMPWFFMIMPQQTTKYVNNFSEKFKSVLPSSKCLQLAINLLCYDQTKRFSATEALQSDYFKEEPKPEPLVLDGLVSCHEYEVKLARKQKRPNILSTNTNNKGNGNSNNNNNNNNDDDDK
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.
Sequence:
MPRPSGPRDPIAGPDTPAPPFPLRLRGPVIKGFGRGSKELGIPTANIPLEGLSIGGHDDLDSGIYYGWCTLDHSSIAAQTTTTSVPSATEDTSPPSRSSNHAVADLEYTSAPAPSSTTIYPTVLSIGFNPYYKNTQRSIEIHILANFPADFYGATLSLVILGFIRPEYDYVSVEALVEDIRTDIRVAQKSLEREAYQSWKRDEWLRGKGGGQVGQVDGVGVSRME
The following text describes a protein:
Function:
Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MSIQWFPGHMHKARLEIQAALPKVDVVMEIIDARIPYSSENPMLADIRGDKACLKVLTKSDLADPHRTEEWLDALNSSSSTRARSVTTDDVPTIRRLKSALIGMCPHRKGRSINAMVMGIPNVGKSTIINFLAGRKVAKTGNTPAVTQHQQRVDIGDGVILWDTPGMLWPKVHNVSSGYRLALIGSIKDTAMDYTDVGFFAARYFMEQYPDRLASRFDLESVADTEMAVIEDIGRRRGCLGRNNRVDLERASRILIQEYRTGGLGRLTLETPATMQRERILTQKAMVEAEEAARLKDEKRKKRFKNKQKAQRKSREMDASRRDRRQ
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MPIFRYLFRCLGFFTEVKCDADGPRSPTQRRTEGSTCGDQLRVALAESPRAASIQISDDDGLVMPSVDGEATATERGAATHPGGDLQNHLNNVEREEDARHHLPGDADIILTSGDDGPVMPSVDGEATATERGVATHPGDDLQNHLNNVEREEDARHHLPGDADLIQTSGDDGPVMPSVDGEATATERGVATHPGDDLQNHLNNVEREQDARHHLPGDADLIQTSGDDGPVMPSVDGEATATERGAATHPGGDLQNHLNNVEREQDARHHLPGDADLIQTSGDDGPVMPSVDGEATATERGAATHPGGDLQNHLNNVEREEDARHHLPGDADLIQTSGDDGSVIPVADDGCDSHHRDDAQNLEEVLYHIAIAESLEYQGLPALVDFDGFRGFKLDDHDDEEVARLIALELGQSSNNPPPPAPDAHCSICMEDKYSFECMAIKGCSHTYCACCVSQYVASKVEANEARVGCPDPNCETGFLEPEMCRLILPAKVFDRWGCRLCEEGILGSAKFYCPYGDCSALLIDDGGDAVDHSKCPHCMRMFCAQCRVPWHSGYSCKDYETLCPDKKSRDLMKLATRKRWQRCPNCGFFVERTSGCNYIKCR
The following text describes a protein:
Function:
Specifically methylates guanosine-37 in various tRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MRFDVVTLFPAIFDGYLTQSLLDKAIVRGLVEIQRHNLRDWAEDTPHRKVDDRPFGGGPGMLLQVEPTVTCVRDVDAMADVPARKILLTPQGRRLDQRLAEDLATSDRIMLMCGRYEGFDQRVLDILQPEEISIGDFVLNGGEVAAMTIIDAVVRLLPGVLGDEQSSLDDSFSRGNRMLEFPQYTRPREFEGHTVPDVLLSGDHAAIAAWRAEQSRARTIDRRRDLLPEHSKNNPEQTNKLS
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.
Subcellular Localization:
Endoplasmic reticulum. Nucleus.
Sequence:
MEDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSSETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITRALHIPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKSHFIPDHLSKDTTFIHQIFGGVKQALEQLVKPEELNGENAYHCGPCLQRAPASKTLTLHTSAKVIILVLKRFSDVTGNKLAKNVQYPECLDMHPYMSQQNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQEVTASSITSVLNQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRQATDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEFNVREVEGTLPPNVLVIHQSKYKCGMKNHHPEQQSSLLNLSSMTPTDQESMNTGTLASLQGRTRRSKGKNKHSKRALLVCQ
The following text describes a protein:
Function:
Transcription factor that acts with ADA2 to promote cell wall integrity. Regulates the expression of target genes in concert with the transcriptional regulators SWI4 and SWI6. Crucial for proper cell cycle dynamics and responses to echinocandins, which inhibit beta-1,3-glucan synthesis. Has distinct transcriptional targets under basal and stress conditions. Also regulates a transcriptional network that influences the response to fluconazole. Plays a key role in adherence, hyphal development, and virulence. Acts as a repressor of hypha-specific genes during yeast-form growth.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes to the cytoplasm under basal conditions and translocates to the nucleus under cell wall stress.
Sequence:
MENYLLSSPTQLSQPYDDGTNSLLFMDNYELSQNLSQPLDQHLQSLQQQSQVQSQAPQQVQSLNQHQQLPQIQPFPTLVNNQQYAQETFQQLSQQHQQQQQQQQQFSPFQQSQLQQQFQYQYSQQQQQQHFQQPVTIEEEIVPASNNTNIQISKFFDDNKGDDEDIANSGNFNEFDHSRNISLDDTTITDLHRRENSINPPTGLPHSISSNTIYSYSSFESPQSHIQSQPSYSQGYHNQNSLSTPLRRNKSYSISSANFNQSPVNLATTAMNKIMKTPLRGHTRSRSKVDVNAAVTAAMNLGQATKSNSTSSYNSTLNPFYTPSQQLSSTDDDDISTPLLTPGTKLHTSKSTFFSPYNKDDLEDQDDDAVKQLRKAKSYTSLLRKKKREDMTPSKQNQQHQQQQQQQQQQQQSRQSGGGHIQNLSFPNSTSQPKIDLLAYDQNPMTSYPPMDKSILKNLNQSISPFNKPKLSPPPSNFPSISIDLTTIATNKSSSFSSSTTHRNYNENTPFNSANSTSGGLLPPMATFTVPTVIKEELQVHNLQEEEQEHQDEQMEIDSFESNEKNARPTLSTSSLVRSMKMANLEISNDQQMSSNEDENIVTEAVVKQEKNGPVVDDVNGTGTNSKKPRKKQKSKSKENCNKKGKVATGNGKDNDKNNECLVNKGNKTNNNDTSNDKLDNDNKNTNGNGNNDNDNDSEENNDNVDDADDDDDGTVTIPIPEDLNVTKVKVRNNRSKSNDKSDPKKKHKCPICESRFQRPEHVKRHLKSHSSEKPFECQMPNCGKRFNRKDNLKAHLKKIHGLVKGQEEFTRVLNENKEVS
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
Miscellaneous:
MISCELLANEOUS: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.
Sequence:
MRTEIATLGEFGLIDRLTEGIKPENESTKYGVGDDAAVLSYPSEKQLLVTTDLLMEGVHFDLTYVPLKHLGYKSAVVNFSDIYAMNGTPRQITVSLALSKRFSVEDMEELYSGIRLACQQYHVDIIGGDTSSSLTGLAISITCIGDADKDKVVYRNGAKDTDLICVSGDLGAAYMGLQLLEREKTVLKGEKDIQPDFTGKEYLLERQLKPEARKDIIEKLAAANIVPTSMMDISDGLSSELMHICKQSNTGCRVYEEHIPIDYQTAVMAEEFNMNLTTCAMNGGEDYELLFTVPIADHEKVSQMEGIRLIGHITKPELGCALITRDGQEFELKAQGWNPLKEDK
The following text describes a protein:
Function:
Possible role in spermatogenesis.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MGGHLSPWPTYTSGQTILQNRKPCSDDYRKRVGSCQQHPFRTAKPQYLEELENYLRKELLLLDLGTDSTQELRLQPYREIFEFFIEDFKTYKPLLSSIKNAYEGMLAHQREKIRALEPLKAKLVTVNEDCNERILAMRAEEKYEISLLKKEKMNLLKLIDKKNEEKISLQSEVTKLRKNLAEEYLHYLSERDACKILIADLNELRYQREDMSLAQSPGIWGEDPVKLTLALKMTRQDLTRTQMELNNMKANFGDVVPRRDFEMQEKTNKDLQEQLDTLRASYEEVRKEHEILMQLHMSTLKERDQFFSELQEIQRTSTPRPDWTKCKDVVAGGPERWQMLAEGKNSDQLVDVLLEEIGSGLLREKDFFPGLGYGEAIPAFLRFDGLVENKKPSKKDVVNLLKDAWKERLAEEQKETFPDFFFNFLEHRFGPSDAMAWAYTIFENIKIFHSNEVMSQFYAVLMGKRSENVYVTQKETVAQLLKEMTNADSQNEGLLTMEQFNTVLKSTFPLKTEEQIQELMEAGGWHPSSSNADLLNYRSLFMEDEEGQSEPFVQKLWEQYMDEKDEYLQQLKQELGIELHEEVTLPKLRGGLMTIDPSLDKQTVNTYMSQAFQLPESEMPEEGDEKEEAVVEILQTALERLQVIDIRRVGPREPEPAS
The following text describes a protein:
Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSDKPGMAEIEKFDKSKLKKTETQDKNPLSSKETIEQEKQAGES
The following text describes a protein:
Function:
Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
Subcellular Localization:
Lysosome.
Sequence:
MMRRQQLTFPTLVLLVLINNSLGYEIDLSTANGYAWSAALPNKSIAVPGRVPGSIYTDLDEAEIFTGGPLLFRFNDLEYRWVSYEDWDYSLTFDVPANVASYSAVDLVFYGVDTVADIELNGSPLGATNNMFIRYKYNIKDFLKTDVSNELLIRFKSPVKYARDRYDEQAVDYPVLPTCLDPAYQGECHANHIRKMQSSFSWDWGPAFPTVGLWHPVKLEAYNTVSIRDWWVGFERDEIQQLWKVDMKIHCETPDSGIDHAGTFTVTITDQQQVVQTLKQETVLTGDGNRQVSTPVISFVVPFSQIKPWMPNGWGEQKLYDMKIEYQETGSAEPPVVLDEKIGFRTVDLIEDDLPTGRTYYFRVNGEPVFLKGSNWIPSAVLPELITEQYLRELLTASKDAHMNAMRIWGGGIYEFSEFYRIADELGILIWHDMMYACSMYPANEQFLETVSVEIRQQVRRLSHHPSVLIWAGNNENEAALRQNWYGTESKFETYKADYIKLYVDTIKRILNEEDPSRPFTVSSPSNGKKSEEEGYVSLNPGNPEYGDVHYYNYFDDMWNWETYPKPRMATEYGFQALPSVHAWTTAANPIGMDEDWHYDGQLLFTRQHHPGGNNELVLQVEGQLGKARETTQEQRFLDMIYLTQMHQAEAIKIESEHYRRLQYLDFDGLGHCMGSLYWQLQDIWQGPSWASIEYGGRWKPLHHFATKFFAPLSFMLWVRDGNVAIYPHDYRSGADMVPGILLIKLQSWSQINPIVTERIPNVNGNSTIEWQKPLDSWLSDNGCSRQTCFLTATYQDPETGRHLAPDSYLYPSNFTAVTNLAKANVQVTSVGQVYESSQSSWTIDVELSTDKPAAFVWLDTTTDRKGRFSDNAFLMSTATKTVSFWSSDPITDSTEFSNELRIAHLAEIIR
The following text describes a protein:
Function:
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Sequence:
MFLHGTSRQNERGHLEIGGVDVLSLAERYGTPLYVYDVALIRERARKFQKAFKEAGLKAQVAYASKAFSSVAMIQLAEQEGLSLDVVSGGELFTAIKAGFPAERIHFHGNNKSPEELAMALEHQIGCIVLDNFHEIAITEDLCKRSGQTVDVLLRITPGVEAHTHDYITTGQEDSKFGFDLHNGQVEQAIEQVLRSSAFKLLGVHCHIGSQIFDTAGFVLAADKIFEKLAEWRETYSFIPEVLNLGGGFGIRYTKDDEPLAADVYVEKIIEAVKANAEHFGFDIPEIWIEPGRSLVGDAGTTLYTIGSQKEVPGIRKYVAIDGGMSDNIRPALYEAKYEAAVANRMNDACHDTASIAGKCCESGDMLIWDLEIPEVRDGDVLAVFCTGAYGYSMANNYNRIPRPAVVFVEDGEAQLVIQRETYEDIVKLDLPLKSKVKQ
The following text describes a protein:
Function:
Required for vacuolar biogenesis.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSLAEDWIDPNSSEDSDIQEDAELEYTADNPEKEQRGVFSLEKVQLQFPVSIRCLAVENNILVMALTSDKLMIVDLERPEDIIDIELPKKVLALGLTYKIFLDPSGHYIFVTTTAGDNCLFTPSHQGRVLTKLKGHTVEAVQWNLNGGNILELLIASKSGVLLELVLTLDSANLKRIEKSINTLYSFPFMESPMGILKNIQDDSMTIVTNKRILRFEPKTSRGKDQLYFSPAFQGSMKEILSFSEEETAQCFSYSPFPKNLAEPYTLALKTSKRIIYLDIMNPVNPDIQDYEFNESPKLSVPTVEMNMILTSFHLAFLDLDTLYIVNRVNGKESYQQRVNLSPHEEILGLCCDHEKNTYWLYTTDSLHELVVNNETREASLVFLEKGDFEKALECANTAKVRNTVLVGYAEFLMEHEEYERAATLYAETLKSVEEVALKFIELNQKDVLRLYLWKKLRSYKSTMKIQKSLLVNWLLELMLAKLNSLDEKERLELFPENVMQQRQQVQREFSTLLNQYKDEINREAAYNLANNYGKEEQLLQIATVMKDQSYIMHYWVQRENYEKALETLNEGVSQETLIQHATALLTHRPNETVSIWERQTDLDVHALIPSLLSYNQRSHVPVEENAAIRYLRYVTGVLGCVDPSIHNTLFCIYACHSSSNESYLMNYIEQQGNHPLYDMDLGIRLCLQFNCRRSAVKILVLMKLYSQGVELALEADDCELAATIANIPEEDVVLKKTLWQTIAKYMFSKKSGIKETLRFLENSEVLQLPELIRLLPEDIKLDDLSDNVCDELDHCMKRIEQLDFEIGQASEVAHEIQTNAENMRNRYIVLEPNESCWHCNQPLFSEPFVLFPCQHAFHRSCMLEKTYKLASEKNILKECQLCGPSYAVRLINEPFSTDF
The following text describes a protein:
Function:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
Subcellular Localization:
Nucleus.
Sequence:
MYQNAMQQVISHLLSQGLTPAQAQQQAHAYVQQNLQQLISQQQHAQGQHQQAISQQQQQSATLPESTTEAQRKVQQQPVQQIPAVQPVATYETHRLIAAGAGVMPHHIMKVPNPKFDLKSFKAPVTMVRQDPYKIRQEQYRLDAIRQGKEFKAAGRGDNQIDGNIGLGGINISLDKDKIAPFGNAAKQKQNLFKKKTRTYYLSRDHEDAGNSDRLGDTDMILTSVNARHGDPDRHPWVLQDDDDQYYTGNLEGSQGSNYMLFVFVNGGFKVIPATKFYKFMPRVNYRTLTVDEAEEQMKTKTRSKVSSHSDRWVMRNKEGIDGEKSMSLMDKLRNNIIDDEPKHAVVKTKREAEPGLDYTEEFADDEEINFGIDDAEDAKDAARRMFGEDRANQRFEDEEDVDAELDNLRKGKVAKNSRFTSAWYLLGMLTIQRVSSLDSNCQKIAKSLVKHEKNDVYEMDEENPYVSDEEEDEELNEMEEQKDEKAAQQQAIAAKKEADLIMKIRRDVSGSSTKLQRSGSISGTQSPRVASPTSPSSQPSATSPLSNTSTANGKNRPKSGGSTPGPASSSEIKRRRESSVSTGMTGHNSPPPPPAPAQVIARELEKQKEQRSKKRARMSIASQGDAPSSPFNPTQHQSSSKPSSRPQSSSPASPHNSQVRQPTPRSISHSSAASPSALSVPGSPPRSGDSENTGAVLTEEHIIRVIQAKKGAPITVKDIVAHVRNFLQSNPTNKDLLRQIMRRVVVHDKETGIVTLKDEFKGKY
The following text describes a protein:
Function:
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSVHKTNDAFKVLMNSAKEPIVEDIPKKYRKQSFRDNLKVYIESPESYKNVIYYDDDVVLVRDMFPKSKMHLLLMTRDPHLTHVHPLEIMMKHRSLVEKLVSYVQGDLSGLIFDEARNCLSQQLTNEALCNYIKVGFHAGPSMNNLHLHIMTLDHVSPSLKNSAHYISFTSPFFVKIDTPTSNLPTRGTLTSLFQEDLKCWRCGETFGRHFTKLKAHLQEEYDDWLDKSVSM
The following text describes a protein:
Function:
Has a role in both calcium and manganese homeostasis. Involved in the transfer of iron and Mn(2+) from the cytosol to the vacuole for storage of these metals (By similarity).
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus membrane. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MWSIFEARPKEAHSVNKIGWLRASVLGANDGILSLSGLLVGVVAANADIKVILITGVAGLMSGALSMAVGEYVSVSSQADLEDADLQLERREMDADWDAEVDELAAIYRGRGLDEELSRTVAVQLMEYNALEAHARDELGINIHTTAKPTLAALSSAASFSVGGIFPLLTSLITPLEYLSLVLPIATMFFLGMLGFVGAHIGGAKRVRAILRAVVLGLLAMAATALVGRLLEIHALSLQYAI
The following text describes a protein:
Function:
May facilitate the progression of anaphase through direct or indirect interaction with the cut8 protein.
Sequence:
MKHIKNEREEVFLEDDQAQHSQAELLSSKDENLQPSIPLSPVAFELDFSGNFQFISDNSSELLDIPKDKIIGHSVAEVLGTDGYNAFMRAVNCLLKDDSHSYHVRFQHSINANHANQNYYTAKGDLPSDEKITKPFDAIGILIRHPGSAIPAHTMWVVNPATNSLGSVSPLVTKLLDVIGFGASLLDKYLCDLRTSYHKHNSLDALPLPTPEFCQICEREIQSWFFELHSKFCLSTSTYESVVQAAQDSLLYFRSTLLEIQEGMQKDSSLVPVYKNEPLIVDADDYFFTDENKQTLSLCSFLSQVMYYLEVAIDITIPPVKIIVNFDKVDSLRVQSPRSEKATIELDNYNPSLENCSSAVIALWEDIKTAVDTKITGVLRLRNAIYYSERIRLEIDHHVQEIIDDVVSNLVTNHSSTSLGHLESKLAPSITFPDACDALEAEECITRPGSATNTPQSDRSLDINDLSRSSSYSRHLSHVSLSNPDFAIGSPMSQDSSNYSSPLHRRKASDSNFSDPRFDDLKYLSPNSSPRFVASDGPNRPASNGRSSLFSRGRASNLGDVGLRLPSPSPRIHTIVPNSAPEHPSINDYKILKPISKGAFGSVYLAQKRTTGDYFAIKILKKSNMIAKNQVINVRAERAILMSQGESPFVAKLYYTFQSKDYLYLVMEYLNGGDCGSLLKTMGVLDLDWIRTYIAETVLCLGDLHDRGIIHRDIKPENLLISQNGHLKLTDFGLSRVGYMKRHRRKQSSSIPVLDLRDRSSAISDLSLSTASSVLEAQSLITPERPKRPSLNEKLLSLDGTSIRLAGQSFNYENSAEDSPTATNTPTSQVDESNIFRSTDSPRVQPFFENKDPSKRFIGTPDYIAPEVILGNPGIKASDWWSLGCVVFEFLFGYPPFNAETPDQVFQNILARRINWPAEVFTAESSVALDLIDRLLCMNPANRLGANGVEEIKAHPFFKSVNWDTILEEDPPFVPKPFSPEDTVYFDSRGLKGFDFSEYYNQPTVTEAQKLEEERPASSIPQHVSGNRKGRLRSNTISTPEFGSFTYRNLDFLNKANRNTIQKLRKEHMAVKSAKTSVDDTFSQYMSRFKAKLSTSQSVGPVKSSRRASMADYEASTTTRVQDITTDSIDSIDDFDSLKEGRMLSFFDNLALEDHKGVSSTMSASQSQSSMHTALPDVTEGTSSDEHTTIQKGRIDNLQAQSLTHKRNAISYPGLFQLDRLQMIIPKDEIELAEILKKIFPKLTLVLIDDPWSILKKLLQNEQFNVVFLHFGNDKVSSSRLMYSVRTSATINSRVPFVYICEDETCIPTDLQSDGVLLKPITCENIESCLRKLDVWHS
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MSLIRAFTAASRVPRASLLSCVAVRFNSTSKASKQPLLAEIYPLNKDSITEKDLDNWIDAVKQLKSGKASHETPEEIYLGQLSQPQQFLKQTYEPTVDQIEETKKYANKKIPLRSDPTVDNLTNLIMRHGKKAKAQKVVSRALYIVQLKLRKDPIEVLRETLDKLGPLVNTKTMSTGVAKKRVVPIPLNEKQRNRFAIKWILEASNSRKSNDFSVRLAEEIINAYQGKSSGYDKKAQMHKQATQQRAYINL
The following text describes a protein:
Function:
Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Involved as a regulator of Golgi positioning and morphology. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration (By similarity). Participates in vesicle transport between the endoplasmic reticulum and the Golgi complex.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle membrane. Golgi apparatus, cis-Golgi network. Note=Localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Also detected on tubulo-vesicular structures in the cell periphery that frequently localized along microtubules.
Domain:
The N-terminal region associates with membranes, the coiled-coil region binds to microtubules and the WH2 domains promotes actin nucleation.
Sequence:
MDSEQPDSLDGWVPLREDLFPEPERHQLRFLVAWNAAKGQFAVTCHDRTAQRRRRERREAGDGGCSWAGVLSPAGFRGAHRQLAALWPALEPCFPPLPPELDAASGAGWGLGRGLWALLWPLLWPAPADPGDSALQELCRQLEHYLGLAAEGCGGATVRDVLFPAPGDSADCEGLSEFRERTLRARLGQTATRLHQVLQDHGKANTMVALMKVYQEEDELYQELVTMATTFFQYLLQPFRDMREVATSCKLGILKSLDEDELGPRRVAALQKEASEWTRQAEEAVGSIQDITVNYFKETVTALTGMQKQMEQDQKRFGQAAWATAMPRLENLKLMLARETLQLMRAKELCLKHRQAEIQRKVEDLPRQGKQLDVVDELEIQCYEIQLELYDVKLEMLRNEETILVTRLDSVKRLITEKQAEVIYYDPCESPEELQSLAPDLELHLGDNRELRALSQQCQRLEAQRGRICSRRALLRNRKDHCRENHQLRLQQAKQSLRHLHQHHSIQMKRDKVKEEEQKKKEWIDHERQKTLERLRAYKEKCPAHRSALKTTCSESMVSNLPGGRSQKRLSTAHHHKTAHPASSKTGSAVPLPEASVRPPEHQDPCGSVPVQAFVPVSDQTLSGSSEDLSLPPQPPAPPLPPPPPPPPPPPLPPALSSFQGTTHQNLGLRTLATEDRPLPLACDPSAGRPCDYQGPGSMDEVLASLRQGKASLRKVETPTLPHPGTSVNEQVLAAIRQGVQLKKVHTGQGVDPGKKSTSDLERSIREALERIKKVSADSEEDNDEPSPTEWDR
The following text describes a protein:
Function:
Stabilizes the F-actin cables forming the F-actin ring that surrounds the nucleus during interphase. May work in conjunction with myo2.
Sequence:
MSYLSKNGSNDNNNIIKKLVDAEKHCNAVKDASFDERTWIWIPDSKESFVKAWIVEDLGEKYRVKLERDGSERIVDGFDAEKVNPPKFDMVDDMAALTCLNEPSVVNNLTQRYEKDLIYTYSGLFLVAVNPYCHLPIYGDDVVRKYQSKQFKETKPHIFGTADAAYRSLLERRINQSILVTGESGAGKTETTKKVIQYLTSVTDASTSDSQQLEKKILETNPVLEAFGNAQTVRNNNSSRFGKFIRIEFSNNGSIVGANLDWYLLEKSRVIHPSSNERNYHVFYQLLRGADGSLLESLFLDRYVDHYSYLKNGLKHINGVDDGKEFQKLCFGLRTLGFDNNEIHSLFLIIASILHIGNIEVASDRSGQARFPSLTQIDQLCHLLEIPVDGFVNAALHPKSKAGREWIVTARTREQVVHTLQSLAKGLYERNFAHLVKRLNQTMYYSQSEHDGFIGVLDIAGFEIFTFNSFEQLCINFTNEKLQQFFNHYMFVLEQEEYTQERIEWDFIDYGNDLQPTIDAIEKSEPIGIFSCLDEDCVMPMATDATFTEKLHLLFKGKSDIYRPKKFSSEGFVLKHYAGDVEYDTKDWLEKNKDPLNACLAALMFKSTNSHVSSLFDDYSSNASGRDNIEKKGIFRTVSQRHRRQLSSLMHQLEATQPHFVRCIIPNNLKQPHNLDKSLVLHQLRCNGVLEGIRIAQTGFPNKLFYTEFRARYGILSQSLKRGYVEAKKATITIINELKLPSTVYRLGETKVFFKASVLGSLEDRRNALLRVIFNSFSARIRGFLTRRRLYRFNHRQDAAILLQHNLRQLKLLKPHPWWNLFLHLKPLLGTTQTDEYLRRKDALINNLQNQLESTKEVANELTITKERVLQLTNDLQEEQALAHEKDILVERANSRVEVVHERLSSLENQVTIADEKYEFLYAEKQSIEEDLANKQTEISYLSDLSSTLEKKLSSIKKDEQTISSKYKELEKDYLNIMADYQHSSQHLSNLEKAINEKNLNIRELNEKLMRLDDELLLKQRSYDTKVQELREENASLKDQCRTYESQLASLVSKYSETESELNKKEAELVIFQKEITEYRDQLHKAFQNPEKTHNINDVKSGPLNSDENIYSTSSTTLSILKDVQELKSLHTKEANQLSERIKEISEMLEQSIATEEKLRRKNSELCDIIEALKYQIQDQETEIISLNADNLDLKDTNGVLEKNASDFIDFQGIKSRYEHKISDLLNQLQKERCKVGLLKQKTENRSVTQHTLDGNSPHPSFEEKHSGDPLKRIDGNNDDRKIDNKLLKTISKSLDALQLTVEEELSNLYSLSKDLSFTDISGHIPNSIRKLEKGLSTLSELKERLNASNSDRPSPDIFKDTQAIMNSRKLLSNPNSDAQSGLISSLQKKLYNPESNMEFTGLKPLSPSKISNLPSSQPGSPSKRSGKMEALIRNFDQNSSIPDPFIVNQRNSVLQTEFEKINLKLKEATKSGILDNKDLSKFSELIQSLLKENEELKNLTTSNLGSDDKMLDFAPLLEDVPNNTRNQIKGFVEKAISSKRAIAKLYSASEEKLFSTEKALREITKERDRLLHGLQGPSVPTSPLKAPTASQLIIPNFDGSITNYSGEEETEWLQEEVNIMKIKELTSTVNKYREQLAMVQSLNEHAESSLSKAERSKNYLTGRLQEVEELARGFQTTNADLQNELADAVVKQKEYEVLYVEKSNDYNTLLLQKEKLMKQIDEFHVIRVQDLEEREKKDQLLFQRYQKELNGFKVQLEEEREKNLRIRQDNRHMHAEIGDIRTKFDELVLEKTNLLKENSILQADLQSLSRVNNSSSTAQQNAQSQLLSLTAQLQEVREANQTLRKDQDTLLRENRNLERKLHEVSEQLNKKFDSSARPFDEIEMEKEVLTLKSNLAQKDDLLSSLVERIKQIEMFALKTQKDSNNHREENLQLHRQLGVLQKEKKDLELKLFDLDLKTYPISTSKDVRMLQKQISDLEASFAASDIERIKGIDECRNRDRTIRQLEAQISKFDDDKKRIQSSVSRLEERNAQLRNQLEDVQASETQWKFALRRTEHALQEERERVKSLETDFDKYRSLLEGQRVKRSESRLSMRSNRSPSVLR
The following text describes a protein:
Function:
Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs). Also identified in a modified version of SAGA named SALSA or SLIK. The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities. SGF73 tethers the DUB module to the rest of the SAGA complex through its central domain and activates the ubiquitin hydrolase UBP8 by maintaining its catalytic domain in an active conformation. SGF73 mediates recruitment of the TREX-2 mRNA export factors SAC3 and THP1 to SAGA, which is crucial to target TREX-2 to the nuclear pore complex (NPC) necessary for export of mRNA. Upon environmental stress, involved in the bypass of the canonical mRNA export process for the immediate export of stress-related transcripts to maintain proteostasis.
Miscellaneous:
MISCELLANEOUS: Present with 486 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MRSGDAEIKGIKPKVIEEYSLSQGSGPSNDSWKSLMSSAKDTPLQYDHMNRESLKKYFNPNAQLIEDPLDKPIQYRVCEKCGKPLALTAIVDHLENHCAGASGKSSTDPRDESTRETIRNGVESTGRNNNDDDNSNDNNNDDDDDDDNDDNEDDDDADDDDDNSNGANYKKNDSSFNPLKRSTSMESANTPNMDTKRSKTGTPQTFSSSIKKQKKVKQRNPTEKHLIDFNKQCGVELPEGGYCARSLTCKSHSMGAKRAVSGRSKPYDVLLADYHREHQTKIGAAAEKRAKQQELQKLQKQIQKEQKKHTQQQKQGQRSKQRNVNGGKSAKNGGKSTVHNGNNINEIGHVNLTPEEETTQVLNGVSRSFPLPLESTVLSSVRYRTKYFRMREMFASSFSVKPGYTSPGYGAIHSRVGCLDLDRTTDYKFRVRTPQPINHLTNQNLNPKQIQRLQQQRALQAQLLSQQQQQQQQQQQHHSPQAQAQASTQQPTQGMVPNHFPGGATNSSFNANVSSKQIQQQQQQQQHKSQDTGLTPLEIQSQQQKLRQQQLQQQKFEAAASYLANATKLMQESNQDSHLSGTHNNNSSKNGNNNLMTMKASISSPNTSVNSIQSPPSVNSVNGSGQGVSTGINVSGNNGRIEVGIGNSVNPYNGRIN
The following text describes a protein:
Function:
Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.
Sequence:
MFTGIVTDLGEIVSFTPTAQGQLHRLRIACSYDQTTIADGASIACNGVCLTVVASGVAGGKAWFDVDAAAETLALTTAKHWRVGTRLNLERALKIGDELGGHIVAGHADGIATIVSREDLPDMARFVLSTTRELARFIATKGSITLDGVSLTVNTVADVTFSVLIIPHTLTVTTIGGWKAGAEVNIEVDLMARYAARLTEMK