lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MCAQPVANTKEVRWQKVLYERQPFPDNYVDRRFLEELRKNIYARKYQYWAVVFESSVVIQQLCSVCVFVVIWWYMDEGLLAPQWLFGTGLASSLIGYVLFDFIDGGEGRKKSGRTRWADLKSALVFITFTYGFSPVLKTLTESVSTDTIYAMAVFMLLGHLIFFDYGANAAIVSSTLSLNMAIFASVCLASRLPRSLHAFIMVTFAIQIFALWPMLQKKLKACTPRSYVGVTLLFAFSALGGLLSISAVGAILFALLLISISCLCPFYLIRLQLFKENIHGPWDEAEIKEDLSRFLS
The following text describes a protein:
Function:
Promotes flowering by suppressing FLC-mediated inhibition of flowering through the regulation of FCA pre-mRNA alternative processing. Regulates mRNA maturation including alternative polyadenylation, splicing or transcription initiation of stress-associated genes.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MDSEKILNPRLVSINSTSRKGMSVELPQKPPPPPSLLDRFKALLNQREDEFGGGEEVLPPSMDEIVQLYEVVLGELTFNSKPIITDLTIIAGEQREHGEGIANAICTRILEAPVEQKLPSLYLLDSIVKNIGRDYGRYFSSRLPEVFCLAYRQAHPSLHPSMRHLFGTWSSVFPPPVLRKIDMQLQLSSAANQSSVGASEPSQPTRGIHVNPKYLRRLEPSAAENNLRGINSSARVYGQNSLGGYNDFEDQLESPSSLSSTPDGFTRRSNDGANPSNQAFNYGMGRATSRDDEHMEWRRKENLGQGNDHERPRALIDAYGVDTSKHVTINKPIRDMNGMHSKMVTPWQNTEEEEFDWEDMSPTLDRSRAGEFLRSSVPALGSVRARPRVGNTSDFHLDSDIKNGVSHQLRENWSLSQNYPHTSNRVDTRAGKDLKVLASSVGLVSSNSEFGAPPFDSIQDVNSRFGRALPDGTWPHLSARGPNSLPVPSAHLHHLANPGNAMSNRLQGKPLYRPENQVSQSHLNDMTQQNQMLVNYLPSSSAMAPRPMQSLLTHVSHGYPPHGSTIRPSLSIQGGEAMHPLSSGVLSQIGASNQPPGGAFSGLIGSLMAQGLISLNNQPAGQGPLGLEFDADMLKIRNESAISALYGDLPRQCTTCGLRFKCQEEHSKHMDWHVTKNRMSKNHKQNPSRKWFVSASMWLSGAEALGAEAVPGFLPTEPTTEKKDDEDMAVPADEDQTSCALCGEPFEDFYSDETEEWMYKGAVYMNAPEESTTDMDKSQLGPIVHAKCRPESNGGDMEEGSQRKKMRS
The following text describes a protein:
Function:
May be a transforming oncogene with exchange activity for CDC42. May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (By similarity). Involved in the regulation of actin polymerization (By similarity).
Sequence:
MPEGARGLSLPKPSLRLGCGHQGEVCDCAAVSDTPTAQAATTMASPRGSGSSTSLSTVGSEGDPSPACSASRPEPLPEPPIRLHLLPVGIQGSVKPSRLERVAREIVETERAYVRDLRSIVEDYLGPLMDGRALGLNMEQVGTLFANIEDIYEFSSELLEDLEGCSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSVSPPATLWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPDSGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGTFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGPEYTYKGHIFCCNLSVSETPRDPLGFKVSDLTIPKHRHLFQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKHIPEPPTSPLDSPRPRDAPGFTPGRRNPAPSPRLSGSRRGRRQSEPAKEAYVIFPQNDKPQVKHAGSEGELHPSSELQPVSASGLPEDLEDAGPPTLDPSGTSITEEILELLNQRGLRDSGPATHDIPKFPRDSRVPVESEPLPFQSLPSRESSEEEEEEDLETDEREPSPLHVLEGLEGSSAAEIPCIPSLTDIPSEVPSLPEIPEAPCLPCLSDISGVFEVPCLSPTSTVPDIPSLATTPSFPCGSWLPGPLQEAAQPQATRRELLSGSNPGRLSESPSESREGQEDDTEGVSFSAVQREAGTSVQGFPEELEYRSCSEIRSAWQALEQGQLARPGFPEPLLILEDSDLRGGSTSGKTGMPHSERSASRVRELARLYSERIQQMQRAETRASTNAPRRRPRVLAQPQPSPCPPQEEAEPGALPAFGHVLVCELAFPLNCTQESVPLGPAVLVQAATPLCIQGDDLSGQNLNVSDLSKQGHLSSNSIPPPVPLPGQSNFQNIQVPSTSLLPKQEPPDVQVPTASTLPDTSQLQSQVPAATPSAGHRNCVEIQVQSTTSLPGQECQADTVALSKQEGHEDSQNPNKAPGAEQRDVSIDQGLAVVGGRPVSPLPVCTSSPDQQIPATTPLPLSTDFPDMEGPGALPLPTQEGRPDCSIPCNPLPSLSQDVQVPAVIPVSQLQGLTDTRATVPLSSHKQEDAPECLGPEPSLTDTPAPRLLSSLGQQNTTDGPVSAAAVPLTEQGCSQDLQGLITSPVQTTMELPKPRGLVSRVATSESLDLTPPHSPSLSTRQLLGPSAAALSRYLAASYISQSLARRQGPGGEGTVASQGHWSSSAPTSRAPSPPPQPQPPAPPARRLSYATTVSIQVGGGGRLRPAKAQVRLNHPALLAAPHPGAVGPSQGPGGS
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MLSVQQQPPPALASSTLPLESIARALPDQVPENAPAHCPGTESEQAGKADACAGCPNQDACASAPKGPDPDLPLIKERMSRIKHKILIMSGKGGVGKSTFTAQLGWAFSSRFSGNSVYEDHVAEETKHAANGQGQQAADWDAEKQVAIMDIDICGPSIPTILGLAGQSIHSTSQGWSPVYVSDNLCAMSIGFLLPSASSAVIWRGPKKNGLIKQFLKDVDWTAGLEEDQDEEHENPAVSSLESGCVPIPDSAAAAAAAATSTTPPTLIDYMLIDTPPGTSDEHLSIVSYLKQSGITGAILLTTPQEVSLQDVRKEISFCRKMDVPILGIVENMAGFVCPSCTGYSEIFYPSTGGAKALCDELALTLLGSIPLDPRIGKSCDLGLSFCDEYPDSPATKAYLEVIARVRALVDS
The following text describes a protein:
Function:
Involved in cell integrity signaling during vegetative growth at elevated temperature. Acts positively on the PKC1-MAPK pathway. Cell membrane sensor of oxidative stress in the cell integrity pathway upstream of PKC1. Required to transmit the oxidative signal to SLT2 and to restore the correct actin organization following oxidative stress. Multicopy suppressor of 1,3-beta-glucan synthase (GS) mutation. Also suppresses RGD1 null mutations.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MASCNPTRKKSSASSLSMWRTILMALTTLPLSVLSQELVPANSTTSSTAPSITSLSAVESFTSSTDATSSASLSTPSIASVSFTSFPQSSSLLTLSSTLSSELSSSSMQVSSSSTSSSSSEVTSSSSSSSISPSSSSSTIISSSSSLPTFTVASTSSTVASSTLSTSSSLVISTSSSTFTFSSESSSSLISSSISTSVSTSSVYVPSSSTSSPPSSSSELTSSSYSSSSSSSTLFSYSSSFSSSSSSSSSSSSSSSSSSSSSSSYFTLSTSSSSSIYSSSSYPSFSSSSSSNPTSSITSTSASSSITPASEYSNLAKTITSIIEGQTILSNYYTTITYSPTASASSGKNSHHSGLSKKNRNIIIGCVVGIGAPLILILLILIYMFCVQPKKTDFIDSDGKIVTAYRSNIFTKIWYFLLGKKIGETERFSSDSPIGSNNIQNFGDIDPEDILNNDNPYTPKHTNVEGYDDDDDDDANDENLSSNFHNRGIDDQYSPTKSASYSMSNSNSQDYNDADEVMHDENIHRVYDDSEASIDENYYTKPNNGLNITNY
The following text describes a protein:
Function:
Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHRLAQGRSQDQPSSPATEEPANLSRRLCWGLSVPASRMEEGERSPLLSQETAGQKPLSVHSPLTSGCLGPVPREDQAEAWGCSCCPPETKHQALSGTPRKGPAPSLSTGSSCVKYLIFLSNFPFSLLGLLALAIGLWGLAVKGSLGSDLGGPLPADPMLGLALGGLVVSAVSLAGCLGALCENTCLLRGFSGGILAFLVFEAVAGALVVALWGPLQDSLEHTLRVAIAHYQDDPDLRFLLDQVQLGLRCCGAASYQDWQQNLYFNCSSPGVQACSLPASCCIDPREDGASVNDQCGFGVLRLDADAAQRVVYLEGCGPPLRRWLRANLAASGGYAIAVVLLQGAELLLAARLLGALAARRGAAYGRGARREDRAGXXXXXXXXXXXXXPARG
The following text describes a protein:
Function:
Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress.
Subcellular Localization:
Membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MPTVQTPSQRRANTQFQKNITRRVKTNSKERYVAKHPPTKIPRNIAMFFILLMSGGIILGILRFLLTFFS
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of conidiogenone, a diterpene known to induce the conidiation. The bifunctional terpene synthase PrDS converts isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) into deoxyconidiogenol. The C-terminal prenyltransferase (PT) domain of PrDS catalyzes formation of GGPP, whereas the N-terminal terpene cyclase (TC) domain catalyzes the cyclization of GGPP into deoxyconidiogenol. The cytochrome P450 monooxygenase PrP450 then catalyzes two rounds of oxidation to furnish conidiogenone (By similarity).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MLLLWFGFFSFVCGLVIYRLQFHPLSKFPGPKLAALTSLYEFYYNVVLGGRYLWEIERMHEQYGPIVRITPHELHVADPNFYTEIYAGPTRRRDKDPRLVRLAGQPTSMFATVDHGLHSSRRAILNNYFSKRSIAGLEDMIQGKVQKLVKRLNIACDQGTVVQLDAASSALTADIISEYAHGVSLDYLDDVNFNNEVADSILSLASVVHVLKFFPFLLDLSKFIPDKVLENLWSHAANILRLQKLVRAQADVALQNGGKVNGQATMFGALCDPSLPAQERTLDRLQDEGFSLIGGGTETTTGTLKVIMFHLLNEKALLRKLRKELEESPSGTWAELEKLPYMRGVMNEGLRLSGVITRLPRRAPDEALRYKQWTIPPNSLMSTSSHFVHTNSDLFPDPLVFDPERWIRAEAAGQRLEHMIVTFSKGSRQCMGNHLALAELYLVISTLVREFDMDLYGVTADNIVTHREYGFGVPKERGGGLRVSISRVRTP
The following text describes a protein:
Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Subcellular Localization:
Secreted.
Sequence:
MNTLVILPLLLVTIQVSLSASSSSGCSTFKQQLGSRNEKDILLEMAKQNILSKLHLKRRPKISNTISREALAQALLRLNIRLQEDSSREQVEELNNDQDYEVISFADIEHSQASQTILHFHLSTEKGTYREIHNATLWLYLQPDRNKKIAISITTSLSKEKPSTEMIYREIVRSGWYTVPLPMLTEAAFVDGEENIDLYLECLNCTGQPVIENTSDAQRPFLVVKAHNQRDDHRFRRHITECSSDVDMCCKKNFYIDFKEIGWSDWIISPEGYNMNYCEGRCPVHLARVPGIAASSHTAILSLIKANNLYASFSSCCVPTKRRPLSLLYFDMYNSIVKTDIPDMIVESCGCT
The following text describes a protein:
Function:
Metalloprotease.
Subcellular Localization:
Secreted.
Sequence:
MRRNELLNYYLSSFLILSLSYASIHAEKDLLPQSTSSETFLTDEDFLRPLYDDETFLTEKDFKNGEKLGEDHVAAGSILWKQVYKKGDIRGKAAWKLDSKNSESLRRNGVITGTRKWPNGRIPYVISNQYNDRERAVLARSFQAYHDKTCVRFVPRTAVDNDYLYIGKIDGCYSDVGRAGGRQELSLDNGCLQYDTAIHELMHSVGFYHEHERWDRDEHITILWHNIDREAYDQFGKVDLAESSYYGQLYDYYSIMHYDSLAFSKNGFETMVAKAPEMTAVIGAAIDFSPIDILKMNLMYQCSDVKLPATIVASTVPPAVVPAPAPGITVVEDDCRDRTNLCWRWIDRCKSFFFEQIMKEFCALSCGYCTPKTLQTAKASPPNYSNTMLTKSSTSYLQHG
The following text describes a protein:
Function:
Mediates cleavage of dimethylsulfoniopropionate (DMSP) into dimethyl sulfide (DMS) and acrylate. DMS is the principal form by which sulfur is transported from oceans to the atmosphere and is a key component of the ocean sulfur cycle.
Sequence:
MGSASSKTRKDKAKSSTIAACPTDTAAAKACPTRLDDGLAQVAMFAGLRQVTMGVLRIDYDYQTNLGDILDPRSFDFRLVSATVEGLTFKRAQEGEPLPCYVMSNLDGAVKKLIDAGADFIVGDCGFLVYWQVYVRDFAQQYAGGRACPVMLSSLVLSLPLLATIPVGGKIGILTASKGSLMKMQKKLASVIELQKEEARTRAVPAAVQPSGIEINFSDPRFKVVGLDTVNSFKTALADDSGVDDRRSIAIEIAKYCKQVACEDPAICAWLIECTEAGGFSWAIKLGTGLPVWDPVTIGRFLSLGFTSSLPSVALTLGETGQVALDPNETDVSKGRPTKAEHRFGPEFEEMLQ
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5.
Subcellular Localization:
Nucleus.
Sequence:
MALAIKKRVGTYVETVDGSPPVKKLRLQTLAADAKGGKSGKVGNVERKLTALNQLDAYVGNLPAGALVLPTGTPVASTGAPSTGVIGNPPAAATGAPPMTAANSRELLELLVKITDEISYEDVEMGELKEVASKIFQLYQLQERDSDTSIRVKLLELLSGLGCECATEQALTMIIDYFIFLLRKEVSQKVLAQGMMCLFRIGERRKHMLPISYKTQVAHLAKEQLRSGSAHTQKNAMLVIGRFATKMEGERHYVWKLAFYIDSQDSSVRAQALHALLTLGERGSQLPAVLYKRAVEAMKDDYECVRKEALQLVFMLGNRHPDYILPSDRQQEELRMIDAAFSKVCEALCDLSLQIRVLAAELLGGMTAVSREFLHQTLDKKLMSNLRRKRTAHERGARLVASGEWSSGKRWADDAPQEHLDAQSISIIASGACGALIHGLEDEFLEVRTAAVASMCKLALSRPDFAVTSLDFLVDMFNDEIEDVRLKAIYSLTAIAKHIVLREDQLEIMLGSLEDYSVDVREGLHLMLGACRVSTQTCLLMVVQKLLDVLAKYPQDRNSTYACMRKIGQKHPHLVMAVAVHLLYVHPFFETPERDVEDPAYLCVLILVFNAAEHLVPIISLLPTATHRHYAYLRDSMPNLVPQLPIEGASSASATHRIDSAMHQAGSSAEYLQMILSHIEEIFTMTDERLELLQTAQSNLQRLGSIDAGMYGTSNFLETFLAAQIQIEQMQRCASTQRSRVPLKESLAALIRNCLKLQHTFSGLNYGDILQVKQLRLRACALHLVLVVRDRSQSALGPCQMLLQTAGDISEFIKANTKDEEEKPPVVETDMPMKESVSRDAQPDSFTRQLLIKLDGISDPKPGRVFREILPLVQQAPPLALPPANDKIRRCVANILEPCPLQSQDNVIKVTAGLIAAVPFVAEIDNLLESQKADMRIKIKYPDQHMHTVVPKQSDFKPIMTEQGEHKTNVRLRTTILLSHSVWTESSLVEIQLCLAVRPGSELELCKPAKVLFAPKPVRRGI
The following text describes a protein:
Function:
Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters. Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively. Also possesses acyl-CoA retinol acyltransferase (ARAT) activity that preferentially esterifies 11-cis-retinol, a chromophore precursor of bleached opsin pigments in cone cells. Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13-cis-retinol, and all-trans-retinol substrates.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLLPSKKDLKTALDVFAVFQWSFSALLITTTVIAVNLYLVVFTPYWPVTVLILTWLAFDWKTPQRGGRRFTCVRHWRLWKHYSDYFPLKLLKTHDICPSRNYILVCHPHGLFAHGWFGHFATEASGFSKIFPGITPYILTLGAFFWMPFLREYVMSTGACSVSRSSIDFLLTHKGTGNMVIVVIGGLAECRYSLPGSSTLVLKNRSGFVRMALQHGVPLIPAYAFGETDLYDQHIFTPGGFVNRFQKWFQSMVHIYPCAFYGRGFTKNSWGLLPYSRPVTTIVGEPLPMPKIENPSQEIVAKYHTLYIDALRKLFDQHKTKFGISETQELEII
The following text describes a protein:
Function:
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
Subcellular Localization:
Cytoplasm.
Sequence:
MKEDPKHIHISEYNYPLPDERIAKFPLAVRDQSKLLVYRHGEVSEDVFTSLPDYLPKGSLMVFNNTKVIQARLHFRKETGALIEVFCLEPIQPNDYVLNFQQTEHAAWLCMIGNLKKWKDGALKREMTVKGFPITLTATRGECRGTSHWIDFSWDNPEVTFADILEVFGELPIPPYLNRDTEESDKETYQTVYSKIKGSVAAPTAGLHFTPRVLEALQEKGIDLEELTLHVGAGTFKPVKSEEIEGHEMHTEYISVNRATIKKLIDHDGCAVAVGTTSVRTLESLYHIGVTLAENPDATEEELHVKQWQPYEKYDQIPPVVALQKILGYLDRNGLEALHSSTQIIIAPGYQYKIVKAMVTNFHQPQSTLLLLVSAFVKGNWRTIYDYALAHDFRFLSYGDSSLLIP
The following text describes a protein:
Function:
An essential gene required for embryogenesis; required for cell viability.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MALIRCCFEPPELPEFFDSFVQKCTDPSCCCGCCSALRPRYKRLVDNIFPVNPEDGLVKSNMEKLTFYSLSSPDKLDRIGEYLYQKATKDINRKRYKLAEIAMEAMDLLLQACHAQTTLNLFVESFLRMVQKLLEDSNPNLKIMATNSFVKFANINEDTPSYHRRYDFFISKFSSMCHSDAASMRDSLRLAGIKGLQGVIRKTVSDDLVENIWEAEHMEKIVPSLLFNMQFCVNVMFVKKNLLASGDLTPVEDATNVTPPALAEEVLRELVGRASFGHIRSVLKPLLTHLDRHELWVPNTFAIHTFRIVMISIQPQYSYTVVETLMQHLDNNFKSSPKTRTSLAVVLSKIIAIAAGESVGPSALDIINNLLTHLRTSVSTTSEITPEESQYQEALINALGEFANHHPDYQKIEIMLFIMNTVPDLSKKSKGDQMLQNILLKSLLKVGTQYSTVSFEKAFPASFLQPLLKMARAPHNPTRMVVMQILQALLDRHQNEQVLSSVSVKPYPALSQEPPSRSDIIFTHKYGANIMQALIDSMALSDRVDALTSSFNTAALLIVEMSCNETVQEFLLFILGIQQVACTVDTLGNVHKCSLHAISIGLLVLISRVSGINNLLEYAQKIVDARREEASHFLPPLLEPKKLAGKTFNLQLPHLAIDKLALGECLQNAGMDAQRLNTGAPYSLNQTDHPGHRHSWVESVSNQLTQRNSSADLTVYNGDVDSVSSSPGVCKKLLAPEFNFDAMKRALAEPTEAAKREQRERQMQIVRTFREGEFDDLMRRTEPKHDLIQNRLNELFNSLAVERQITQSDTKSSQLQASNEKPIYETNFPELFYY
The following text describes a protein:
Function:
Microtubule inner protein involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Functions at the initial step of left-right asymmetry specification of the visceral organs.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MSEEDPKACAEPEEPKAGPPPEKTSDWYRVSEDLPARFNNPAWFRGYRTKEPPSVYRTSNQAYGSRAPTVHEMPKVFYPNSYKFSRQVAVGGMFQNNTLNVYMEKSIVTGPDNYITSYDRLNFHPSYRVCRPSICD
The following text describes a protein:
Function:
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
Sequence:
MTPHISAKKDDISKVVLMPGDPLRAKWIAEQFLDQAKLVNEVRGMFAYTGQYKSKTVTVMGHGMGIPSIGIYSYELMNFYEVETIIRIGSCGALAPQLKLKDLVIASKAWSESIYAKDMGVEIPEDKILFATSSLVELAKETAIKNKLDFHEGLVFCEDAFYQTRKDVISLAKEKNSLAVEMEAHALYANAILLKKKALTLLTVSDSLVTHEALSSELRQKSFKQMALLALEMTQKLI
The following text describes a protein:
Function:
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing. In the heterodimer formed with mettl14, mettl3 constitutes the catalytic core (By similarity). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing and translation efficiency (By similarity). M6A is also involved in hematopoietic stem cells specification: m6A methylation and subsequent destabilization of mRNAs, such as notch1a, leads to decreased Notch signaling, promoting endothelial to hematopoietic transition. M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (By similarity). Mediates methylation of pri-miRNAs (By similarity).
Subcellular Localization:
Nucleus. Nucleus speckle. Cytoplasm. Note=Colocalizes with speckles in interphase nuclei. Suggesting that it may be associated with nuclear pre-mRNA splicing components.
Domain:
Gate loop 1 and gate loop 2 regions are adjacent to the S-adenosyl-L-homocysteine-binding site and display large conformational changes upon ligand-binding. They may play an important role in adenosine recognition. The interface loop contributes to the heterodimer interaction.
Sequence:
MSDTWSHIQAHKKQLDSLRERLQRRRKDPTQLGTEVGSVESGSARSDSPGPAIQSPPQVEVEHPPDPELEKRLLGYLSELSLSLPTDSLTITNQLNTSESPVSHSCIQSLLLKFSAQELIEVRQPSITSSSSSTLVTSVDHTKLWAMIGSAGQSQRTAVKRKADDITHQKRALGSSPSIQAPPSPPRKSSVSLATASISQLTASSGGGGGGADKKGRSNKVQASHLDMEIESLLSQQSTKEQQSKKVSQEILELLNTSSAKEQSIVEKFRSRGRAQVQEFCDYGTKEECVQSGDTPQPCTKLHFRRIINKHTDESLGDCSFLNTCFHMDTCKYVHYEIDSPPEAEGDALGPQAGAAELGLHSTVGDSNVGKLFPSQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRKLNIPILQDDGFLFLWVTGRAMELGRECLSLWGYDRVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNRGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPEVVARFKKRYPDGVISKPKNM
The following text describes a protein:
Function:
Plays an essential role in generating the deoxyribonucleotide precursors dGTP for DNA metabolism. Highly specific toward deoxyguanosine (dGuo) and deoxyinosine (dIno). Only marginal activity is observed with guanosine. UTP is slightly more efficient as phosphate donor than CTP, ATP and GTP.
Miscellaneous:
MISCELLANEOUS: Catalysis proceeds by a classical ping-pong bi-bi reaction mechanism.
Sequence:
MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLDKFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSPHQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLISDYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV
The following text describes a protein:
Function:
Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MEGHRKKRRKVGLGDDEEATGDTVRSNGMDTVDVQKLERAAPKVTGPQGGISSNWMKMKAEIASSGRQKRGSHPRATSLQAAAKVVQQVAEDEKVGSPQPLGKDMGPTKVVAMDCEMVGVGDDGVRSILARVCLVNAHGNVLYDKHVQPLERVTDYRTHVSGVRAKDLKKTAEEFFQVQKEVAALLKDRIVVGHALQNDMQALLLSHPKRFIRDTSKYAPLRKHGRPRALRHLAEEILGLRIQAGEHSPVDDARAALYIYLKFKKDWEQSLLPKKQKRIQAPEKTPAKSEKR
The following text describes a protein:
Function:
Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Essential for retrograde trafficking of IFT-1, IFT-B and GPCRs. Negatively modulates the SHH signal transduction.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MDSQGLQTLINYYCQERYFHQVLLVASEGIKRYGNDPVFRFYHAYGTLMEGKTQEALREFEAIKNKQDVSLCSLIALINAHKRSPNPDREAILESDARLKEQRKGAGLKALYHAGLFLWHIGHHDKAREYIDRMIKMSNGSKEGQILRGWLDITRGKDSYTKKALRYFEEGLQDGNNIFALLGKAQCLEMRQNYSGALETVNQIIMNFPSFLPAFIKKMKLQLALKDWDQVVETAQRILLQDNQNVEALRMLALYHLCRDGDIEKAATKLENLGNALDAMEPQNAQLFYKITVAFSRTCGRSQLILQKTQTLVERAFNLTPQESEFATELGYHLVLQGKVKEALKWYNASLTLGENNVSALIGCIQCQLIEGQLQEAEHQLEFLREIQQSIGKPAELTYLHAILAMKKNKRQEEVINLLNDALDTHFSHLEDLPLGIQYFEKLNPDFLLEIITDYLNFCPMQPASPGKPLSPFLRRCTSVLETIVRTVPGLLQAVFLIAKVKYLSGDIEAAYNNLQHCLERSPSYADAHLLMAQVYLSQEKFKLCSQALELCLSYDFKVREYPLYHLIKAQSQKKMGEITEAIKTLRMAMNLPGMRTGASSKSKCTKTEVDASHRLSIFLELVEVHRLNGEQHEAAKVLQDAIHEFSGTSEELRVTIANADLALAQGDVERALSMLRNVTVEQPYFIEAKEKMADIYLKHRKEKMLYITCYREIAERMPSPRSFLLLGDAYMNIQEPEEAIVAYEQALNQNPKDGTLASKIGKALVKTHNYSKAITYYEAALKSGQQNYLCYDLAELLLKLKLYDKAEKVLQHALAHEPVNELSALMEDGRSQVLLAKVYSKVNRPGDAVTSLQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQRDYEKAIKFYREALVHCETDNKIMLELARLYLAQDDPEACLRHCALLLQSDRDNEAATMMVADIMFRKQDYEQAVFHLQQLLERKPDNYKTLSRLIDLLRRCGKLEDVPRFFSMAEKRNSRAKLEPGYQYCKGLYLWYTGEPNDALRHFNKARKDCDWGQNALYNMIEICLNPDNETVGGEVFENLDRDLGNSSEKQESVQLAVRTAEKLLKELKPQTVDGHVQLRIMENYCLMATKQKSNVEQALNTFTEIATSEKDHIPALLGMATAYMILKQTPRARNQLKRIAKMNWNPIDAEDFERSWLLLADIYIQSAKYDMAEELLKRCLRHNRSCCKAYEYMGYIMEKEQAYADAALNYEMAWKHGNQANPAVGYKLAFNYLKAKRYVDAIDVCHQVLKAHPAYPKIRKDILDKARACLRP
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MNFVLALTINTLLALLLMILTFWLPQLNPYMEKSDPYECGFDPAYPARIPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMTTSSLMLIIILALGLTYEWSQKGLDWTE
The following text describes a protein:
Function:
Required for acclimation to reactive oxygen species (ROS) responses downstream of beta-cyclocitral (beta-cc) or mediated by dihydroactinidiolide, including singlet oxygen 1O(2) detoxification reactions, especially upon light-mediated photooxidative stress, and leading to programmed cell death. Prevents leaf senescence. Involved in cold acclimation.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, Stress granule. Note=Moves from homogeneous distribution in the cytosol to discrete spots (e.g. stress granules (SGs) and processing bodies (PBs)) in response to singlet oxygen 1O(2) exposure. Accumulates in nucleus after beta-cyclocitral (beta-cc) treatment.
Sequence:
MTGKAKPKKHTAKEIQAKIDAALTNRGGGKAGIADRTGKEKGGHAKYECPHCKITAPGLKTMQIHHESKHPNIIYEESKLVNLHAVLAPVAESKPKPGIRGSLKK
The following text describes a protein:
Function:
RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (By similarity). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (By similarity). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing. Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (By similarity). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm.
Domain:
The xRRM domain binds the 3' end of 7SK snRNA (7SK RNA) at the top of stem-loop 4.
Sequence:
MKVCQRKTIDTEKMSSVGDTACADLSEKKDNEKKKRSRVKQLLSDVKKQVEFWFGDVNLHKDRFMKSIIEQSRDGYIDIAVLTTFNRMKNLTADVKLIARALKNSTIVEVNDEGTRIRRKEPLGETPKDVDSRTVYVELLPKTVTHIWLERVFSKCGHVVYISIPRYKSTRHSKGFAFVEFETQEQAQKAVEMLNNPPEDAPRKPGIFPKTCRKKAVPFDAVTQDNDEDGKKKKTELKNSTSEETGSNNMDQDGMLESTVTSEPNLATLTSTVSKKAKKKRLRSQSFEASSGEDQFEMSSKMRKVEEEKSELKDLSSENKDEELNSLKKKDDSVLKAKRKRKKKLKERLKVGEEVIPLRVLSKKEWLDLKQEYLTLQKRCMAHLKQSVFQINQKPTNYHIVKLKEDDTNAFYKDTPKKELTSGPEFLSGVIVKISYNQPLPSKRCIKDMLSELSPVAYVDLLDGDTEGHVRFKSSEDAQKVIKARFEFQKKYNWNLELLSGDHERRYWQKILVDRQAKLNTPREKKRGTEKLISKAEKIIIAKAKEASNHIRFDD