lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MAESIFRKLRDGGEEGELAPALTIEETVASPFGLDVSGYLLTNLSSSILAGKSSSQGLVLITFSRSPSFYLQLLKQKGIVVSSSSKWIRILDCYTDPLGWIDQSSTSFSEGSSLIKLHKCVSDLKKLFSSIIEAGRELVGTGKTRFCVAIDSVNELLRHSAMPLVSGLLTDLRSHAQISSVFWSLNTDLHQEKVTNALEYISTMKANLEPLCPSSDGQRNALENLFSVHQDFGKGRFHVRFKLRKGRVRVMSEEYHVDQSGINFSPISSVDTVIAATKSLLPKVQFNLQLSEKERVEKEKVVLPFEHQDDGKSNEIYDGRRSLVDGKIETTPLSSMELQTDVVSSGKGGEIIYFRDSDDEHPDSDEDPDDDLDI
The following text describes a protein:
Function:
Required for accurate chromosome segregation in meiosis. Required for pairing to occur between homologous chromosomes. Acts in early recombination steps and ensures pairing fidelity and proper repair of meiotic DNA double-strand-breaks. Regulates recombination and pairing of homologous chromosomes during meiotic prophase by controlling transport of RAD50 from cytoplasm to the nucleus. May affect pairing of the gene-rich fraction of the genome rather than preventing pairing between repetitive DNA elements.
Subcellular Localization:
Cytoplasm. Note=Localizes to the cytoplasm during leptotene, zygotene and pachytene.
Sequence:
MAGSLTASNRRRNAEDSSEIYRWTIGFARFVHYPSSPSPHPVLKPLGKREQYHSPHGTWLSASSSTVSLHIVDELNRSDVILSVKLGQKVLEEHYISKLNFTWPQMSCVSGFPSRGSRAIFVTYMDSANQIQKFALRFSTCDAALEFVEALKEKIKGLKEASTQNQKNKTRCDVSFQSDYNPSDAIIPRATQKEPNMVRPLNSYVPEMLPRIVYEAQYQKSETRSEVSFQSDYNPSIEIFPRATEEEPNMVRFFDSSVPEVLPRPEYEAGQALYPSQSTLNQIPSLPPSFTTLLSGCFPDSTLDAGQTTVKQNPDLKSQILKYMEDSSFQDMLQKVERIIDEIGGNWIT
The following text describes a protein:
Function:
Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. Together with HTL1, NPL6, RSC3, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity. May be involved in the transfer of mannosylphosphate (MP) groups into N-linked oligosaccharides.
Subcellular Localization:
Nucleus.
Sequence:
MSGSNMGYYDVLAGLSALEKSSQVVFSATELQQLTQQSHATDKGIEGSENSKAKVSKPKRVAVHGYLGGKVSLADAAQVEYEVGHSLLGSYVPRQQLEALSSVDFSHHFHRTLECKAALETHDVFLAGAGQLSLPFQSHIESPRNSEAKRKRKVIICKRCQSRFIGSHRRSQLREHACVD
The following text describes a protein:
Function:
Toxic component of a toxin-antitoxin (TA) system. An RNase.
Sequence:
MIFDTDILIWVQRGNVKAAGLIEKAEERMISIYSYMEMFQCATAKSQHKIMHAFLREYDFKIQPLSEKIGHRAAIYIEEYALPSGLRAGDAIIAATAVENNWVLATSNNKHFKCIKDLQFNLFKP
The following text describes a protein:
Function:
Vacuolar Fe(2+) uptake transporter.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MSISDNSITSPVRAPTDLERNVVSQPDVNYAKRANLLRAMMFSANEGLVFVALLIIVGSKKMTSKELVVIGLLSIVANACKMAIGEYVSVSTQYDIHMAQIERKRESGGIIMTEEEENLPSPTQAAGASALASALGGLLPLLSGVLVNPWEIRVVVVCVVTSLGLGATGGYFGGCSVKRSAIKVFIGGLIRLFFGLFFELEIKSSGDKFDDDDSEYILCCFVYLYFNFEMFLHAHLSFYFS
The following text describes a protein:
Function:
May be involved in the early steps of the plant defense signaling pathway.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Domain:
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Sequence:
MARLLFRLLVESNTPSPAIDNSTAALNSDLVVILAALLCALICVLGLIAVSRCVWLRRLAAGNRTVSGSQTQSPQPPVAAANKGLKKKVLQSLPKLTFSPESPESEKFAECAICLAEFSAGDELRVLPQCGHGFHVACIDTWLGSHSSCPSCRQILVVARCHKCGGLPGSSSSGLESEPEIEIRIKQGEDDPNSFLP
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.
Subcellular Localization:
Nucleus.
Sequence:
MILSIPQLILPLSTTTNSEEPIHHPQQNSHLCSTPQVHAYLFTNVIDTQQLLTHLRHVPPILPTAVYLDASKIFSLFQLSLAVTKTHLNKCTNKMRTHSDQSEILLSLSGDTSISQAFKQFGISKHTCNVLVVDYSGNDQIENHNQEILQDLTRHIHGTHIAEFTDLDNIRDMKAIRKVG
The following text describes a protein:
Function:
Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MFPGSTWTVIVEQIAEYEEVIDPKAFFDKIISLWKEYPNAISNRITTSVSVDTDSDLWNEVLRTFETHYKFCPRDCSEIAITKIIHKDLANNKFSDNAFEVSYYEEELLVRFYPITLDGMQHPHFESPYSIAIKIPTDTSIQLQFLKQANSSQEHFEFMKKQAFKQLYTWLKGIDLSKSSRKTNSLLDKESYIKTYRHIREDYGRGMIKGWTENSNPQKSIFEDCGIASYINELVNSDLLPKPNKFVDIGCGNGLLVHLLNKIGMSGYGIDVRHRNIWKTTLKDVDLREMPVDPQIVVQNEPHFDLDVDLLIGNHSDELTPWIPVMAAKLNCNFFLIPCCPFNFFGKYANNGSHLGPKRIVSQYESFFEWTVSVAERLGFDVKIDRLAIPSTKRLCIIGRVPEGGLCPNVDETINSMTEGQKFIARPKEIKTTNCMNIPVTDRERIAKKLFDFVLNYSDAVRDGWRCGGEVPLAQLAALLTEEDKKLMKDQDGGLQTFLRNQHQIFHVYQATARLRDFRQPVVQKRQSWKPKKAETIRKAPCWMSLHHPDGCPVGQEACRYEH
The following text describes a protein:
Function:
Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.
Sequence:
MSRLSTTTPVGALTLRPVDPLTDAVLLHGWLTHPKSAFWMMQDARLVDVERAYMELAADEHQQAHLGLHDGVPAFLTERYDPAHRELVGLYEPEPGDVGMHFLVAPTDRPVHGFTRAVITTVMTELFADPATRRVVVEPDVTNTAVHALNAAVGFVPEREIQKPEKKALLSFCTREQFAKAVSA
The following text describes a protein:
Function:
Involved in peroxisome biosynthesis.
Subcellular Localization:
Peroxisome membrane; Single-pass membrane protein.
Sequence:
MARTGLQRHRGKLLGTGAVLGGLVVAGVVAAVAAKRWVRRQQQRLSEQHYVREQIKRRFTQTQQDALYTMYELVPVLALVLGKELDVEELVETLKGKKLKRAGEDDEQGSGGHASAGEGSVSSTVARSKAELWQELKMRSAVKLLAVVYTTCMLLLLTRLQLNILARREYLETAIRVAKGEEATRRDAAGWLGAVWEYGAAALGALGPRPAVTAVEPVDQHEETRYVNEQAFLSLSWWLLNRGWLQFKPLIERQVEQQFGTLSPRDTLSMEQFSARLSNTIHAVNRELFDSDSRALLLRALLPDATEELHVLQQTLDEGSLRVIERDDSMLRELLQETCRCAESTASLIVLESLVNESFQFVMQQLETKVTKKLRKPATDAPEADGAADAPSQKFQVALYSVALKDCCQEMLKNGLVSMNNEYLQDLDAVPELDDLSASVYSNFGV
The following text describes a protein:
Function:
Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
Subcellular Localization:
Secreted.
Sequence:
MPLATGGRDLTKPLPTLGIEGKGGRVIQPPLGTGTLTAPNSFLVLQGVRTARSRDRALSTVSRGSARGRTRAMFLVCPRFFLLVVLGTRWAGWGSHQAEAAQLRQFYVAAQGILWNYHPESADPSLNSIPSFKKIVYREYEPYFKKEKPRSSNSGLLGPTLYAEVGDTIKVHFRNKADKPLSIHPQGIRYSKFSEGASYLDHTSPAERKDDAVAAGEEYTYEWFIGEDSGPTPDDPPCLTHIYYSYENLTQDFNSGLIGPLLICKEGTLTEDGTQKMFDKQHVLLFAVFDESKSWSQSPALMYTVNGFVNRTMPDVTVCAYDHVSWHLIGMSSGPELFSIHFNGQVLEQNQHKVSTVTLVSATSTTANMTMSPEGKWIVSSLIPKHYQAGMQAYIDIKNCPKKTRSSKTLTREQRRHMKRWEYFIAAEEVIWNYAPVIPANMDKLYKSLHLDNFSNQIGKHYKKVIYREYKDETFTKRIENQSSRQSGILGPIIKAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDGVNSSSTSGSHTMIKPVQPGETFTYKWNILEFDEPTENDAQCLTRPYYSDVDVTRDIASGLIGLLLICKSRSLDQRGIQRVADMEQEVVFAMFDENKSWYIEDNINKFCENPDEVKRDDPKFYESNIMNTINGYVPESISTLGFCFDDAVQWHFCSVGTHDDILTVHFTGHSFIYGRRHEDTLTLFPMSGESVTVVMDNIGTWMLTTMSSNPRRRNLRLRFRDVKCNRNDDDDEDSYEIYQPLEPTSMTTRKIHDSVENDFGIENEDDDYQYELASTLGIRSFRKSLLNPKEDEFNLTALALENSSEFISLSTDGVVDSKSSRNLSKITNNNLNDSQRTLSGSGATIAGILLGNLTGLGKNSVLNPSTEYHSSSYYENDMEDPQSNITVVYLLPLGAKGSGSREQTKPKTIKTGRPHRMKHRFSWMKAPAGKTGRHSNPKNTSSRMKSEEDIPSDLLLLKQKVASKLLNRQWHMASEKGSYEIIPANGENTDIDKLTNSPQNQNISTPWGASTSRINTTGKPSNLPTFSRFRHKSPHVRQEEESGDFKKRQLFIRTRKKKKNRKFALHSPLSPRGFYHPRREDHPPLLDRRLLNHSLLLHKSNETALSTDLNQTSPPVSTDRSLPDYNQNPSNDTEQMSSSLDLFQSVPPEEHSPTFPTQDPNQTHSTTDPSYRSSPPEPSQGIDYDLSHEFYSDDISQTSFFPDQSQKSPLTSDDGQAIPSSDLNLFTISPELDQTIIYPDLDQLFLSPDDIQKTSSQDLGQVTLSPDENQETSSQDLGQVTLSPNENQETSSQDLGQVTLSPDDIQETSSQDLGQVTLSPDENQETSSPDLGQVPLTPDDNQKTSPDLGQVLLSLDDKQKTYFLDPGQVPISSDQSWETSSTDLSLLTLSPKFGQTVISPDLDKMPLSSDNSQVTLSPDLSLLTLSPDFNEIILSPDIDQVTLSPDLIQTSPALNHRHKTSSADPGQASYPPDSGQSSPLPELNQTLPHPDLIHMQPPLLSPTPNDTSLSKTFNPLVVVGLSRVDGDDVEMIPSEELESIDEDYPEDDYVTYNDPYKTDTRANVNSSRNPDTIAAWYLRSFGGNKKFYYIAAEEISWDYSKFAPSEMDNEETDNTPKDTTYKKVVFRKYLDSTFTSRDPQGEYEEHLGILGPVIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKNYEDDSPKWFQEDDAVQPNSSYTYVWHATERAGPENPGSACRAWVYYSAVDVERDIHSGLIGPLLICRKGTLDRASNLPLDMREFVLLFMVFDEKKSWYYEKSKGSWRIESPEAKNSHEFYAINGMIYNLPGLRMYEQEWVRLYLLNMGGPQDIHVVHFHGQILLDNRTKQHHLGVWPLLPGSFKTLEMKASKPGWWLLDTAVGENQIAGMQTPFLIIDKECKMPMGLSTGAISDSQIKASEYLTYWEPRLARLNNGGSYNAWSIEKSALDFPIKPWIQVDMEKEVVVTGIQTQGAKYYLKSCFTTEFQVAYSSDRTNWQIFRGNSMKSVMSFAGNSDASTIKENRFDPPIVARYIRIHPTKSYNRPTLRLELLGCEVNGCSTPLGLEDGRIQNKQITASSFKKSWWGSYWEPSLARLNAQGRVNAWQAKANNNKQWLQIDLLKIKKVTAIVTQGCKSLSSEMYVKSYSILYSDQGVSWKPYRQKSSMVDKIFEGNSNTKGHMKNFFNPPIISRFIRIIPKTWNQSIALRLELFGCDIY
The following text describes a protein:
Function:
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MYKLACLSLIASASAFAPAQTGKQSTSLNSWNEAPRALPFGSAPPTLDGSLVGDVGFDPIGFSTAPFASFNNPIYQEGNFMTDVQWLREAELTHGRIAQLAVVGFIWPALFGTFPGNENFGGADAYSYVNPLEAINHIPSLAIYQIVGGMAWVEYQRVQRIKEQGKDRISGDIGLAYPGGWNPFNINYSPEEYAEKQLQEIKHCRLAMLGAFGLFFQALNSGEDIVSQLSPAFAAPEYAAKAGYFLPQGI
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAFLHRVQAVVALDNTGSRIFAKYFIGEDTPESSKALAPFEKQRSLEHAVFQAIHDPRRGNHVVYESEILVVEGHIALFHISEDVTIIVIGAGSENEVVLSNVLMGLVDALRQELNTPSLTARLLLENYCALLMTIDEMLDEGIILETDSATVANDLEPYLVDVSNDTARAALTGVNKYLRDNL
The following text describes a protein:
Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Subcellular Localization:
Nucleus.
Sequence:
MWDQKLVRLAVVQQLRAVYGIKVKGGRGQCDRRRQEAASTEKVGKIFGVPFNTLPQSLVPEYGHIPSFLVDACTSLEEHIHTEGLFRKSGSVIRLKALKNKLDHGERCLSSAPPCDIAGLLKQFFRELPEPILPGDLHEALFKAQQLRTEEKNTATLLLSCLLADHTIDLLRYFFNFLRKVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSANTEKKLRLQAAVVQTLIDYASDIGHVPDIILEKIPGMLGIDGLCATPSLEGFEEGDYETPGDYKRKRRQSVGDFVSGALNKLKSSRTPSITPQQERTAQLSESPILTPNAKRKLPVDSHGFSSKKRRSIKHNFNFELLPSNLFSSSSTPVSVHFDTSPEGSSQGSLSPVAISGNHLISTGMLRRSKRIASKKVCRVESGKAGCFSPKISRKEKVRRSLRLKFSLGKSSKDGNACSGVDRSENVGRRLASQQSLKNRIESVKTGLLFSPDIDERLTKKGSKKISKSEENLLTPERPGGKSYRMSWTGPSGSSFQEIDGNETSPKDGTLEVENSSLEPDIMLEKSPVSAYEPTPSNVHNKHNNSITGSSLSGDENNLTTETVMKIQKAFSESGSNLHALINHGQSSLTNVEKVKFNETSSIEYSPEKNLFETNNLTVIESNEHHTYKDENSFSEGDLSLHQMQKLDSEITIKCYSTQMKIELESSIHSHIPKDDVSKQELPSDEQIKQESPGDTLNTKLKENENVIELLKSAASREDVASTSSSGQLTCNNANVSKPRPVRIAKQQSLVETCAKTVSERLQMTEHGKVSDHIQWFNKLSLNEPNQTKVKSPLKFQRTPVRQSVRRINSLLEYGGQPPRHKLASLGDTASPLVKSVSCDSALPSHIESTSKDSSIPRTKSGPKEQKSTSCKQTNTDMISKSSMELTCTSFSQMKRHPHSVNASVRSTRVCKQEVISNGQIKVPLDDLTNHDISKSVVNNDMGFSIGINNNKILRKPSEKERVWYKGSPKNPIGKAQLLPSSKPVDL
The following text describes a protein:
Function:
Specifically methylates the ribose of guanosine 2251 in 23S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEIIYGIHAVKALLERDPQRFLEVFILKGRDDRRLQPLIAELEAAGLVIQVASRQWLDSQVEGGVHQGIVARVREGRQYQENDLPALLESVETPFLLVLDGVTDPHNLGACLRSADAAGVHAVIVPRDRSAQLNAIAKKVASGAAENVPLIKVTNLARTLRVLQEHNVWIVGTAGEADHTLYQSKMTGPMALVMGAEGEGMRRLTREHCDELISIPMAGSVSSLNVSVATGVCLFEVVRQRGLKA
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDPQEWYNGLPIVTKTLFTSVLVTTLAGNFGLLSPYTLILNYPLIWGGFEIWRLVTCVFFFGKLGFPFLMNLYFLYNYSLNLERGLFERRTADYVWMIVSIWLTLLVVAYFMSLVMIGLPLVIAILYVWCNVNAEQIVSFWFGTKFKAMYLPWVLVGFNILMGGNGFSELLGIFAGHVYYFLKYKMPENGSPDYLQTPAFVRNIFPDEQGGFGTMGGTTFGQAPASRAAAAAADRRTFTGAGHRLGNQD
The following text describes a protein:
Function:
Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSRMVDTMGDLLTARRHFDRAMTIKNGQGCVAALPEFVAATEADPSMADAWLGRIACGDRDLASLKQLNAHSEWLHRETTRIGRTLAAEVQLGPSIGITVTDASQVGLALSSALTIAGEYAKADALLANRELLDSWRNYQWHQLARAFLMYVTQRWPDVLSTAAEDLPPQAIVMPAVTASICALAAHAAAHLGQGRVALDWLDRVDVIGHSRSSERFGADVLTAAIGPADIPLLVADLAYVRGMVYRQLHEEDKAQIWLSKATINGVLTDAAKEALADPNLRLIVTDERTIASRSDRWDASTAKSRDQLDDDNAAQRRGELLAEGRELLAKQVGLAAVKQAVSALEDQLEVRMMRLEHGLPVEGQTNHMLLVGPPGTGKTTTAEALGKIYAGMGIVRHPEIREVRRSDFCGHYIGESGPKTNELIEKSLGRIIFMDEFYSLIERHQDGTPDMIGMEAVNQLLVQLETHRFDFCFIGAGYEDQVDEFLTVNPGLAGRFNRKLRFESYSPVEIVEIGHRYATPRASQLDDAAREVFLDAVTTIRNYTTPSGQHGIDAMQNGRFARNVIERAEGFRDTRVVAQKRAGQPVSVQDLQIITATDIDAAIRSVCSDNRDMAAIVW
The following text describes a protein:
Function:
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Miscellaneous:
MISCELLANEOUS: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
Domain:
The Walker A ATP-binding motif also binds Pi and PPi.
Sequence:
MTKSVTVKDLKERLNLELICSETGLERPISTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMCTKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKSETALELVKRGHRLVADDNVEIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDKHYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND
The following text describes a protein:
Function:
May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.
Subcellular Localization:
Nucleus.
Sequence:
MSSYRSNFRTVDSQIAGLYDLQETLGRGHFAVVKLARHVFTGEKVAVKVIDKTKIDEVSRAHLFQEVRCMKLVQHPNVVRLYEVIDTQTKLYLILELGDGGDMYDYIMKHDNGLDEEQAKLYFSQILSAISYCHRRHVVHRDLKPENVVFFQKQGLVKVTDFGFSNCFRPGEMLDTSCGSLAYSAPEILLGDAYDAPAVDVWSLGVILYMLVCGEAPFNEANDSETLTMIMDCKYTVRAHVSEECKNLIARMLIRDPARRATLEQIENHPWLQNGNLPPFMVPPMIHRKDIPEEDSRQIMQSMASGKIAELDAIKESVAHDKYDHITATYYLLAERKLRRNLVPDHPRVSLVRQNSAPSDNPRKPFIVAKRPMNADPEDSDHVAKSAMVPGRQSPSRSRSPSPSSSATRIASEAINIPSRHKPPLQGRDHLTISPRRGRSVVLEGVEVLQEEEEEHNLRFSDINSDDDDYDDDDESSKHSGSNDSEEDFRRHLEKMSGGSSLAAGVRMRKVPLNRRIQNRRSTPLTLNEIHEEGEEIESDDDSVHRTSPRILRNRMSIATPESLRKKFSSLQHRKTLRNKASNCSSTDTSDDDTDSRLRRDSGGSLSQHWRRRDSDDDPRGGGGGSGGTGPSQNNNGEGFNGANGTSSNGWNNQNYGSSNGGGTDPNCNSTGLNNANNLRSSNISIASNKSQHRKNSNELRDSLKNSNLSISSHSSSNSKYAIDPSNHTPSESDTQSVDSQKVQWSKPDVLDTQNNFTNIVDTSDMVLTENEINAKMNRSVVLTAARPGVLNSVRTTAMKRAISRSKLDRSVMVRNDPKASHLHSSCCRLV
The following text describes a protein:
Function:
Plays a major role in cholesterol homeostasis. Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol (By similarity). Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia. May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation. May be involved in caveolin trafficking from the plasma membrane (By similarity). In addition, acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
Miscellaneous:
MISCELLANEOUS: Target of cholesterol lowering drugs.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5.
Sequence:
MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGVARCNESQGDDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTILLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDWLTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDGQVLDTVAILSPRLEYSGTISAHCNLYLLDSTSRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPALALEQKRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEGSIKGAGAISNFLPNNGRQF
The following text describes a protein:
Function:
Necessary for normal cell division and for the maintenance of normal septation.
Sequence:
MDAHFLKSASDLKDCPQDNIPEICFMGRSNVGKSSLINAFFKKKLAKTSATPGRTQLLNYFEYKDKRFVDLPGYGFAKINKNKKDFITNLLTQFLNFRSNLVGVVLIVDSGVVTVQDQEVVKIILQTGLNFLIVANKFDKLNQSERYFSLKNIANFLKVNFDKCVFASTKTHHNLALVHKKIFELFVEDER
The following text describes a protein:
Function:
Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.
Sequence:
MSDQIASHGVQWELLVDSGYMLSRGPHLKRAGNSSRMSIENLKTFDPFAEADEDTGQVKQSQQDYIHIRIQLQGLPKKFDQKKILKVIKKKFACNGTIVTDVEMGEVVQLQGDQRKDVQDFLTDKKEGLGLDTKTIKVHGF
The following text describes a protein:
Function:
May contribute to cell wall structure in root hairs.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MAITRSSLAICLILSLVTITTADYYSPSSPPVYKSPEHKPTLPSPVYTPPVYKPTLSPPVYTKPTIPPPVYTPPVYKHTPSPPVYTKPTIPPPVYTPPVYKPTLSPPVYTKPTIPPPVYTPPVYKPTPVYTKPTIPPPVYTPPVYKPTPSPPVYKKSPSYSSPPPPYVPKPTYTPTTKPYVPEILKAVDGIILCKNGYETYPILGAKIQIVCSDPASYGKSNTEVVIYSNPTDSKGYFHLSLTSIKDLAYCRVKLYLSPVETCKNPTNVNKGLTGVPLALYGYRFYPDKNLELFSVGPFYYTGPKAAPATPKY
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MRFLGDIQVQLDEVACLGIAELLKSPSMGEFTREGFVNGWRGVGCDNQQKMIAHAADIRARIPAEPDLFRRVYRYTFPLCRMQGQRNLQFDIAVEQWRLFFTPEHGGIQWNTPTTPWLDWWIEYLEERGKRPVNKDLWEQVEVFLRKTLEDENFGWWSADAAWPGTLDEFVGWVQAKRGKSAEEMEVE
The following text describes a protein:
Function:
Plant-specific actin binding protein. Associates with F-actin at the tonoplast. May be part of a membrane-cytoskeletal adapter complex.
Subcellular Localization:
Vacuole membrane. Note=Arranged into short filaments and foci.
Domain:
The NAB domain, also called NAB (NET actin-binding) domain, is sufficient for F-actin binding.
Sequence:
MDYDLLRSKKSIKRVESTKSNPWWWDSHIGLKNSKWLENNLDEMDRSVKRMVKLIEEDADSFAKKAEMYYQSRPELIALVDEFHRMYRALAERYENITGELRKGSPLELQSQGSGLSDISASDLSALWTSNEVNRLGRPPSGRRAPGFEYFLGNGGLPSDLYHKDGDDSASITDSELESDDSSVTNYPGYVSIGSDFQSLSKRIMDLEIELREAKERLRMQLEGNTESLLPRVKSETKFVDFPAKLAACEQELKDVNEKLQNSEDQIYILKSQLARYLPSGLDDEQSEGAASTQELDIETLSEELRITSLRLREAEKQNGIMRKEVEKSKSDDAKLKSLQDMLESAQKEAAAWKSKASADKREVVKLLDRISMLKSSLAGRDHEIRDLKTALSDAEEKIFPEKAQVKADIAKLLEEKIHRDDQFKELEANVRYLEDERRKVNNEKIEEEEKLKSEIEVLTLEKVEKGRCIETLSRKVSELESEISRLGSEIKARDDRTMEMEKEVEKQRRELEEVAEEKREVIRQLCFSLDYSRDEYKRLRIAFSGHPPTRPSSILAS
The following text describes a protein:
Function:
Contributes to the transfer of mature mRNA from the nucleus to the cytosol. Required for both R gene-mediated and basal disease resistance. RNA export seems to play a critical role in stress responses and regulation of plant growth and development. Required for proper expression of factors associated with auxin signaling.
Subcellular Localization:
Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus, nuclear pore complex.
Sequence:
MEENRRNPSAGMEVPVAGGGNVVKWIEISVPSPSVSSSSIGANSSEDNECVQLPLSEDYASSSVIGEPSISFVWRINKTSPNALELLQLSAKSGFPITGLRFVFAQTLSPFAFVYADEGGDSGRLVYFLYSLTPSGVVYVLKLSNTLAYKSGSVFPLDHLIHLDVRPYLNESRVTSVAASPGFIFLGRSDGCVSCFQPIVYFQKSSGFHQELRDDTGFGRLGTVVAAVQDLFISEVHGRNYLCVLHADGALRVWDILTYSRVLCQSIAAKNLEGVMCVRLWLGKADYDSGIIPLAVLYRKSMNDSMDVITVYGLHFSSAEGIALSLDSGLQNIPLEEGELRDVRFTSDKIWTLKANELTSYMLCQKSSTMEAQSYTLQEDYISEQLFLSSRSSSHDLLLTTHSLFSSAKDQIMGFISSIFLRRLLCPGIFHNVALRLTLLDHNKNWTDSEFQSLSLDELTSEILLLVEHEVTAETSISVFHWWKNFCTSYLHHWCSNNEPRTLLVQSDVIGLVRNNSVSLFFRLENAEHSLGGSSSEHSNLTSLDLGVSHSDHEILAEVLRCTSKISKQWGGAPYAMYYESITGRPIISSDEIVPRLVNILESGYSTTIGQRTWSDLGADRAWEKELEAHKNLRTFSIDMLLSLSALCQRAGSWEKVFTIMEHYLQYLVPKKSMQKNDGEALSDICSSILVQATSQFVKVMFESAFDIFLLISYLLNIAGQVNMSQQDICKLRLELLPMIQDIVSEWLIILFFVTTPAESTSMEDFSLKLSSLQIDSSIDKRSWNAMLGKCGFSLAFILLFSDRSCIVDGRFNLRYLPSSQIITSLVQNFISWIRYSKTGDDSSSLLRRSTELSLRLIRNGQSDAVERILVVVEASLRGEKTFGCSQDTSGDWCLLQHLRGCCLLDQVQRGASGILRERKIIDAIRCFFRASSGEGSWKALHSLSKEAGFSPATTGPSILDGSTSSAAWKLHYYEWAMQIFERYNISEGACQFAYAALEQVDDAYNFIEMTEEFDPTKAATYTRGRLWANVFKFTLDLNLLNDAYCAIISNPDEEIKRICLRRFIIVLFECGKTKILSDGHLPFIGLTEKITQELFWKAGRSDIMMKPNPYKLLYAYEMRRHNWRMAASYMYQFSARLRSEGACKDYKHMSLVLQERLNGLSAAMNALALVHPGYAWIDPVPEETTRYPVKKARRAEEEQLRSNDQPKGEKSCIDIEKLQNEFVFTTAEYMLSLKNFGWTYSGLEKPPSDLVDLLVQANLYDMAFTVVLKFWRGSALKRELEKIFENMAIKCCPAKGTLWSSPNLMLTSNDEEVTHSPDRSPADQGSKLAGDWEILEVYLKRYIDIHARLPVSVASTLLQADSCIELPLWLIQMFKDGQKEKALGMAGQEASPASLFQLYVDYGRLTEATNLLLEYMESFASSKPAEVLKRKKVSGVWFPYTTVERLWWELEKTMNSGRMVEQCHKLKEQLHHALLNHLKLLKVDSNDAVSSATG