lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF6 homodimer connects TFIID modules, forming a rigid core.
Subcellular Localization:
Nucleus.
Sequence:
MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEDALKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGRELYFYEEKEVDLSDIINTPLPRVPLDVCLKAPKEQQKAEATEPLKSAKPGQEEDGPLKGKGQGATTADGKGKEKKAPPLLEGAPLRLKPRSIHELSVEQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRAEFGSLGPLLCSQVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAAAPPQPSPPPTKFIVMSSSSSAPSTQQVLSLSTSAPGSGSTTTSPVTTTVPSVQPIVKLVSTATTAPPSTAPSGPGSVQKYIVVSLPPTGEGKGGPTSHPSPVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGTPKANGSQPNSGSPQPAP
The following text describes a protein:
Function:
Peptidoglycan polymerase that is essential for cell wall elongation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MIDRRLITNFDWMLLGLVLLICAVGVVNIYSASSSYVLSGTPYYLKQMSWVLVGLAIMLLVCSIDYHLLEDVAYWFYGILFLLLLVVLAFGKTSMGATRWLHLGFISVQPSEPMKIIGIITMARILANIPVSGGLGLRELAFPALMIGAPAILIMKQPDLGTAILVILIAGSMLAFVGIRLSALAAVCIATVPAVWLGWHYYLRDYQKNRVLNFLDPERDPLGTGYHIIQSKIAVGSGGLFGKGFLQGTQSQLRFLPEQHTDFAFSVFAEEWGFVGSLVVLLLYAVLTLWGLQIARRCNDRFGSLVAVGVTAMLFWHIIINIGMVIGLFPVVGVPLPLFSYGGTSMITSMTGIGILLNISMRRFMF
The following text describes a protein:
Function:
Major sphingomyelin synthase at the Golgi apparatus. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes. Converts the newly synthesized CER, that is transported from the endoplasmic reticulum to the trans-Golgi by the Cer transport protein (CERT), to SM. Can form a heteromeric complex with glucosylceramide synthase (GCS) increasing SMS activity and reducing glucosylceramide synthesis, a critical mechanism that controls the metabolic fate of CER in the Golgi (By similarity). Does not use free phosphorylcholine or CDP-choline as donor. Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to CER to form ceramide phosphoethanolamine (CPE) (By similarity). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting. Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MSASTMKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGRDLINLTQEDFTKPPLCRVSSDNGQRLLDMIETLKMEHHMEAHKNGHANGHLSIGTDVPAPDGSFSIKVKPNGMPNGYRKEMIKIPMPEPERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLGRQVKYSRLVNDT
The following text describes a protein:
Function:
Critical role in copper (specific) homeostasis and detoxification. May protect by directly chelating and sequestering copper ions.
Sequence:
MTVKICDCEGECCKDSCHCGSTCLPSCSGGEKCKCDHSTGSPQCKSCGEKCKCETTCTCEKSKCNCEKC
The following text describes a protein:
Function:
Processive glycosyltransferase that is part of the biosynthetic pathway of the lipid-linked oligosaccharide (LLO) that serves as the glycan donor in bacterial protein N-glycosylation. Catalyzes the transfer of exactly three alpha-(1->4)-N-acetylgalactosamine (GalNAc) units to the growing LLO precursor, GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenyl. Cannot accept UDP-GlcNAc as substrate.
Miscellaneous:
MISCELLANEOUS: N-linked protein glycosylation in C.jejuni consists in the transfer of a heptasaccharide (GalNAc-alpha1,4-GalNAc-alpha1,4-(Glcbeta1,3)-GalNAc-alpha1,4-GalNAc-alpha1,4-GalNAc-alpha1,3-bacillosamine) from a membrane-anchored undecaprenylpyrophosphate (Und-PP)-linked donor to the Asn side chain of proteins at the Asn-X-Ser/Thr motif.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Domain:
Contains an amphipathic helix (''ruler helix'') that has a dual role of facilitating membrane attachment and glycan counting. The ruler helix contains three positively charged side chains (Lys-67, Arg-71 and Lys-74) that can bind the pyrophosphate group of the LLO substrate and thus limit the addition of GalNAc units to three.
Sequence:
MMKISFIIATLNSGGAERALVTLANALCKEHEVSIIKFHAGESFYKLENEVKVTSLEQFRFDTLYHKIASRFKKFFALRKALKESKSDVFISFLDTTNIACIAAKIGLKTPLIISEHSNEAYLKPKIWRFLRRVSYPFCDALSVLGSSDKVYYERFVKRVKLLLNPCHFSDEISFDSSFEKENLVLFIGRLDHNKNPVMFLKAIAHLDKNLQENYKFVIAGDGQLRQELEYKVKSLGIKVDFLGRVENVKALYEKAKVLCLCSFVEGLPTVLIESLYFEVCRISSSYYNGAKDLIKDNHDGLLVGCDDEIALAKKLELVLNDENFRKELVNNAKQRCKDFEISHIKEEWLKLIAEVKNA
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MAPLPDWVPKADDLEYGHKRVLAIDGGGIRGILVGVVLEYLEQAILEVLKEDKKHANLTRQDIYLADYFDIIAGTSTGGLLALYLAARGDTYDELGDMGRLGLEREMREEPNNPKHHRKGGATAALQMYRANATKIFKKKVPGWIPGVEAINNALCGSKYGWKGIEGVLREVFGDDEGRNPMLKLTDLTGSVLIPSFETKKTSPFTFSYNKYTGRSGFTYMANDPVGRYGADELRNFKADFPLWQVARATSAAPTFFPVAIVSPYGDPPVNKEGVKPPEFPYELIDGGVVANDPAFQAVLVQARMYGAHLKEKNAMNADDWLLPTDFAVLSLGTGTVKSAANQGRGAQLSIVADLVTKVLMSGASDLVHSYFMAMMGNLPKGSEGRDQFERNPPCPYLRIQKTDTSTDDPKELEKLADDVLRKAQKDVTADERNTYKKCLSAMDDVSDKNMDMLEHIGDFLGRYYTGRPLGDRLERPNLLKNYVREYLLAPKKKKN
The following text describes a protein:
Function:
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MIAVFSLIAAALAVGSLVLLPVVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPAAPFVGNVWNLLRGACCFGDQFRELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSRFETTDPTCDTMGSQNLFFSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALFTTDIIASLAFGIEAHSLQNPEAEFRRMCIEVNDPRPKRLLHLFTMFFFPRLSHRVGTHLYSEEYERFMRKSMDYVLSQRAESGENRHDLIDIFLQLKRTEPAESIIHRPDFFAAQAAFLLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDPKAFVLTAHNGTYLRFVKNSL
The following text describes a protein:
Function:
Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions may be to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C (By similarity).
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Cytoplasmic in interphase cells. Accumulates onto both kinetochores and the spindle microtubules in cell arrested in metaphase. Associates with unattached kinetochores in early prophase upon spindle assembly checkpoint (SAC) activation. Present in chromocenters.
Domain:
The KEN box is required for its ubiquitination and degradation; BUB1 N-terminal domain directs kinetochore localization and binding to BUB3.
Sequence:
MAAETKVQVSDPEAEFLNSKQETGYEWELFKENVRPLKRGRNVGILNHALKSHSDHQLRKNLIEKRRNLIEAIDEYEGDDPLSPWIECIKWVQEAFPPGGECSGLLVIYEQCVRKFWHSERYKDDLRYLKVWLEYAEHCADAEVIYKFLEVNEIGKTHAVYYIAYALHIEFKNKVKTANEIFNLGISRDAKPVEKLNDAYKKFMVRTMRRSNTADEEPKENNDLPSRSFGTLLSRGDNNARRQALGSSNPQAKKLKPNQSSKTPFAIYADAVSDTTSGNQPESDKSRPEFGSWLMLGGRAERNKENNSLPRKWASFKVPQKPIVRTVAAASASTFEVFVDEEECTEEEEEKKKNDETISSSSNVLPLNGGREIKKETELLRQNPLRHFPPNSFLR
The following text describes a protein:
Function:
Membrane-anchored myosin receptors that define a distinct, plant-specific transport vesicle compartment.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Domain:
The GTD-binding domain is sufficient for myosin binding.
Sequence:
MAANNFATKLSRNTNRITVILVYAFLEWLLMFFIFLNSFFTYFIVKFASFFGLKQVCLLCPKLDRIFERKPENRFTYKELLCQNHIAELASLSFCRTHGKLSESANLCSDCSNREEEQSNIGLGFCTCCQKSLADKPYPNYLLLKSSIWGKTLGDREDGGLILEMIDDDKFGDGFEIDRESYPLGFFRDKAEEGKKQDQQQNGEVISDVESYGLSLREVSEEDGLRSIISNNSPGNEAKSRVSEDEQRNDDTSNVATYGEDQISGRVEEKEEETGVADLLYDQFESKNFTGSQIEEEEEDREETTKELDPETPTSVSTLFNKKLHFLARNEYAAAEDAGDGNVLVSEMDGGDPLRTIERLRETVRAEQEALRDLYAELEEERSASAISANQTMAMITRLQEEKAKVQMEALQYQRMMEEQAEYDQEALQLLNHLMVKREKEKEQLQRELEVYRAKVLEYESKAKNKIIVVENDCEADDDDKEEENREEDNSSEMDVDLEKITLDCVQHMSMLGESLSEFEEERLVILDQLKVLEDRLVTMQDKESAEDPGEFSNSYEEASNGHGGLTMASMAKSLLPLLDAAENESEDGSQGLPESDEKNFGSDSEKLEIIKQVDSVYERLQELETDGEFLKNCMSSAKKGDKGTDILKDILQHLRDLRTIELTNTIENQTTQEE
The following text describes a protein:
Function:
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
Miscellaneous:
MISCELLANEOUS: Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGKKVLLVYAHQEPKSFNGSMKQVAVEELSKQGCTVTVSDLYTMNFEPRATRNDVTGALSNPEVFKYGIEAYEAYKKKALTSDILEEQRKVQEADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDVPGFYDSGFLKDKLALLSFTTGGTAEMYTKAGVNGDFRYFLWPLQHGTLHFCGFKVLAPQISFGPEVSSEEQRKVMLASWVQRLKSIWKEEPIHCTPSWYFQG
The following text describes a protein:
Function:
May assemble to form gap junction channel-like structures involved in intercellular communication. Channel gating and ion conductance are likely regulated by membrane lipids rather than by membrane depolarization or extracellular calcium levels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKP
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MGPRYDGEYLKELLDKELGVVTLKQTLTQVIIPTYDIKRLFPVIFTTAEAKMDELNNPLLADVCLSTSAAPTYLPSHKFGIEGNSNIFHMIDGGVAANNPTLTAILHEKKAMIIRSELETEKKNKEAKLKMSPKKLLVLSLGTGSFKKIGKYDAEDTAKWGILSWVHKNKTTPIIDIFSDANADMVDIHLATMFQYDHDLHKNDGNKKDNHRKKDYLRIQAADLSGDELCSVDIATKENLENLEIVGEKLLDETVSRVNLKTGRYEKLSSKKGTNREALVKFAERLSKERKLRLSG
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across the thylakoid membrane. Involved in delta pH-dependent protein transport required for chloroplast development, especially thylakoid membrane formation. TATC and TATB mediate precursor recognition, whereas TATA facilitates translocation.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Membrane; Single-pass membrane protein.
Sequence:
MFDLGFQELIIIFIVALLVFGPKRLPELGYTLGKTLNEIKKAFQGAKSEMEKEINEVKETVEEAKKDIKDPLQLKNELFKDIPSLEDLRIDKHIENIARKEIEKKE
The following text describes a protein:
Function:
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.
Subcellular Localization:
Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex.
Sequence:
MTICQFFLQGRCRFGDRCWNEHPRGGGGRPHSGPVRGAGGGWGAASQRYANVIQPPIFKHSTWGGSGDGGGFSGASDFGSPGNKSAVFSQNRFSALSSAHPADGFSDEEQRLLDCVAKDMATWESSGQWMFSCYSPEAGKPNVSGFREFSAEEVRLEYYNCSANNNTENYINSVNQLVQEWRNRLQELKALNASGKESLLSQLKNAVTQPLPSLGFGGQQASSFGFPSFPVSSSSGAASFSFKANPSVPPGNAAAVGSSAAASNPPTLGVTSSPSVPNPVGSGNSSAPSAAPSSLNAPGATGGCGTSGLSGSGSSAAANSSCTALLPGSSAAANSSSTAPLPGSSAAANSSSTAPLPGSSAAANSSSTASLPGSSAAANTSSTALLPGSSAAANSSSTALLPGSSAAANSSSTALLPGSSAAANSSSTAPLPGSSAAANSSSTAPLPGSSAAANSSSTAPLPVSAIPSAATGTSQSGASSASAAQTAGASGHNVTSAPSAVRDGIRP
The following text describes a protein:
Function:
Transcriptional activator which binds to the consensus sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in higher-order sensory processing.
Subcellular Localization:
Nucleus.
Domain:
The second H-T-H motif is necessary for transcriptional activation.
Sequence:
MADCPYARCIQERRHIRRELLRWTKNMVFVVGLERVAEELMGRRRWKQYQDTLYSGTRSSESLTAQAHHRLYPAFSSSCDPVPGNLEQIGSRPLHPPASSTSLPATITTTTTTTTTTTATAAATATTTATGLIKQETLQRHHHLQNHHHHLQSTAVQDHHRPYQQQQQQQQRQQQRQEERRLRPDEIKVEVGEDEFANGGAARDESKAGSTDASTPATVTTTGATTTLPAASATGTGPATPSAVVATSNATAAMTTGTTTIPTRRLRKRRQNDGEGADDRDDDEENEEEEDGRGQSEAEKRLKLDEDADGAVSPLRREKDRGSREYPTSNATDTDGTKERTEEVALDRTPVTQGLLRVKKEEELQEAPSCGGGPTILTTPGLDSDGIRLPCREVEAAATARNVVAPFLIGSRRTSPPPEDWKPLDKCYFCLDGKLPHDDQPPLSPQSDSSSSSRSAESPMSVQVDPMAASVVAAALTGTYPTLLPQWCLPPREAPLVGVQPHQDSATPADQPLDLSAKPKNSQDNNISLLEQQKIPLRMTAGIDPKSIFNSGYRPKPRMSGPVAAVAAAAVAAAGVGGVPVVGAGGGRRAYTEEELQAALRDIQSGKLGTRRAAVIYGIPRSTLRNKVYKLAMERERDASLSSTHSHPHEPGAPATTITTITTTTTTTTTTTTTTTTPNTTQNASATTPPPQVDEVDDKELSGAEEEKEVEKALLKPLLSLEDLVRFSTLEGSGGDSLRTLLQRGQETGAEWPGLEHANIGPYIQKMIAAAAPFKGMETQDYRIPEVMRRLMSEDKRLSKSVNGDQSQPPHQQLHHHQSTHPQAQAQAQPQQQQQQQQQQPQQQQQQQQQQQQQQRGPMTNDDFNPNIEEEASDSAQGRAILKIPSYKPASTPGCSSKNGEPTSAAFAQGFATAASSPGLLERASPAFSGTSSPTNSLVGKTVAVNFRDVIAKSISVKFQEGQTVSGGGMGGCQPGGVVQSQQPIMTDPSPFKRGRYTPPQPANAQQGQAQAQAKPQSQEANKPKPATGGKGTRPKRGKYRNYDRDSLVEAVRAVQRGEMSVHRAGSYYGVPHSTLEYKVKERHLMRPRKRDQKQSDDKTKETSTVTAAAAATNIRPGTADNKPQLKPQKPFTSPGGIPGPNGIKMPSFMEGMPHLPFTPFNFWNPPPFMPSPFMAGAPNVPTILPEQYFATSRIRGLQEQQRNAAMVQQQQQQQQQQQQQQQQQQQQQQQQQHQAREREGVGAGIAETSAGTSNSRGAAQMSKVPRDVSEGIYDGSGANGSFLDNLIRSSLETGIPRDQRAMTEARNQQQQASSQQQIPESMRSKALIDQLCRNSRRTPVPRLAQDSSEDESYRGPSASGGRPVPERPERVPTVDLSPSPSDRGRNDDGSDRLTSPPTPLSISRAGSRDEDSTRDSTKLDRSSREREVHNGGQQEDRDRKTLTSAPQQPQQQQQQQQQQQQQQQQLNHYPDLHNLYAVPTDKKSACDSKLIVDHSSQKTQQQQPQQQQQQQQQQQPQQQSQQPQQQQPQPQQQQQQQQQQQPQQQQKEYGAVSGLVVQLQRGYNSGNNRSGEQANSQQQQQQQSGEPVIGMEDSVEQ
The following text describes a protein:
Function:
May be involved in cell cycle regulation.
Subcellular Localization:
Nucleus.
Sequence:
MADGKAGEEKPEKSQRAGAVGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN
The following text describes a protein:
Function:
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells.
Sequence:
MVEPTLRTSAVVLLLILHNCAANHVFLKGQQASQVLVRNPRANQMFEELKPGNLERECFEEICDHEEAREVFEQTDKTEIFWAKYLDCEGTVKHRTTKTIGLIRDCVEGHCVSGNGHNYNGNIHITKSGRVCQHWSHSFPHPIFREFNASEPNSILQENFCRNPDKRSEGPWCFTKDPSVQKETCRVPKCGEKFVPPTVAPEVVKTTICLPNYGVDYTGDLSVTLGGHTCIQWSSPQAKALSKDKEFIPEVQLTGNKCRNPDNDPEGPWCYVHISGNITVDYCDLDLCEDPLLAQEQETETEGRERSVLAPAKKLFFNPRTFGEGESSCGLRPLFELKSKKDAKEQELLDSYREQRIVGGDDAEVASAPWQVMLYKRSPQELLCGASLISDQWIVTAAHCVLYPPWNKNLTTEDILVRLGKHNRAKFERGVEKIVAIDEIIVHPKYDWKQNLNRDVALLHLRRPITFSDEIYPICLPNKQVARNLMMQGYKGRVTGWGNLKESWNPAARNLPTVLQQIHLPIVDQEICRQSTSVRVTDNMFCAGFKPDDSQRGDACEGDSGGPFVMKHPGENRWYQIGIVSWGEGCDRDGKYGFYTHLFRMGRWIKKVIEKSGGDDE
The following text describes a protein:
Function:
This protein catalyzes the committed step to the synthesis of the acidic phospholipids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKEQIPNLLTIGRILFIPIFIFILTIGNSIESHIVAAIIFAVASITDYLDGYLARKWNVVSNFGKFADPMADKLLVMSAFIMLIELGMAPAWIVAVIICRELAVTGLRLLLVETGGTILAAAMPGKIKTFSQMFAIIFLLLHWTLLGQVLLYVALFFTIYSGYDYFKGSAYVFKGTFGSK
The following text describes a protein:
Function:
Binds the 23S rRNA.
Sequence:
MKQGIHPKYYTDGIVCGTCGTVWKIGSTRPNLRVEICANCHPFYTGEQRIVDTAGQVDRFMRRLNVAQERQNERESRRAARTQPEKKSLLKEIYGEDAE
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSYRLSRNDIRFLKVMYKLSHFLSITPNYDFENFVIISPRCDKISAICFLLSTILGTCWIIYVRIYCKEIRFFEISFEILGSLDSLILLMVLVSIILGSLKTKEWAKLNNKFQYIDEKLKTRDQKERNLFKNAYFQLVLSISVYSSSVGYTQYVRIAAKGLPTLKLFALHEFYGFCYLWVLILICNIALAFKQRYQLINEQMAVRINPKNCASFVIEVRKLSRLLGEMVGLFNDIFGWPLVFITGRFVIKILVALNFFTSTLEIDNLYLKHKLEISSLVQTAITLVAMCGLVLICDSAKSESQQTVFLCYKLMEKFPERSHEQQELYMAAQVIEKSVANFTAAGFFDVKRSTLFGILATTTTYLIVTIQFNQGLNK
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MWRFAALAIILLFSLPNHADSVRLSRPGKLNRQKPLLAAKLSTPAEFLAAHNKIREIHNLTLLAWDQKLAGYARWWADTRLDNCRKLLHSPNSPYGENLFWALRDHWNASKVVKYWGDERNLYDPNTNECINNSVCGHYTQIVWNATQRVGCAHVLCHNIQGHLFVCSYDPPGNIYYHGPFGGRFNKSIVNPPSPNNASSTILGSQSGITGNKANYIVSSTTGHPTNKT
The following text describes a protein:
Function:
Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein; Cytoplasmic side. Cell membrane.
Sequence:
MVFLVYDILLLLLSPAIIAHHAWRTVSRGRSFAGFGERFGFIAPERLIPVAGKRPVWVHAVSVGETMAVKPLLRELKHRYPERPVVLSTVTETGRSIAEKIAEADLVVYFPFDFGFAVSRALRLVSPSLVIVVETEIWPNFLRYARRRSIPAVMVNGRISDRSFPRYLRFSWFFAPLLAKLSALCMQSEEDARRIVAIGGPAQRVFVTRNLKYDLPVRTLSPAEREELHQRYRLPPDTLVITAGSTHAGEEEVVVDSYARLARERSGLFLVLVPRHPERAAEVGTMLQGKGIPHVRRSALDGAPEPAAGGVLLVDTVGELMNLYALSDLVFVGGSLVPVGGHNLLEPASVGAPVLFGPHMHNFREITALVLAANAGEQVEDRAGLEDALRRLLNDEPRRLAMGERGIRLMTEQGGAAARHLEIIGRLLVTGSAE
The following text describes a protein:
Function:
Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MINFDGIKKITERLKWKQGDEDENWAKKAIDNLMKKLIKHNKQALENLEFALRCQGQQKTECVTIPRSLDGRLQISHRKALPHVIYCRVYRWPDLQSHHELKAIEDCRFCYESGQKDICINPYHYKRVHATGVLPPVLVPRYSEKPPQEVPPTLAKFQLMEMSGSRMPQNVNMANVNFTANQFHQYNPNGIEEMDTSQKFDIPPGVPTCLVPFDKVWEEQFWATVSYYELNTRVGEQVKVSSTTITIDGFTDPCINGSKISLGLFSNVNRNATIENTRRHIGNGVKLTYVRSNGSLFAQCESDSAIFVQSSNCNYINGFHSTTVVKIANKCSLKIFDMEIFRQLLEDCSRRGFDASFDLQKMTFIRMSFVKGWGAEYQRQDVTSTPCWIEIHLHAPLAWLDRVLSTMGPTPRPISSIS
The following text describes a protein:
Function:
Responsible for O-acetylation at the C(6)-hydroxyl group of N-acetylmuramyl residues, forming the corresponding N,6-O-diacetylmuramic acid of the peptidoglycan. O-acetylation of the peptidoglycan is the major determinant for lysozyme resistance.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDTKDFKRLEKMYSPRYLPGLDGLRAFAVIGIIIYHLNAQWLSGGFLGVDTFFVISGYLITSLLISEYYRTQKIDLLEFWKRRLKRLIPAVLFLICVVLTFTLIFKPELIIQMKRDAIAAIFYVSNWWYISQNVDYFNQFAIEPLKHLWSLAIEEQFYLLFPLVITFLLHRFKPRNIIQTLFIVSLISLGLMIVIHFITGDNSRVYFGTDTRLQTLLLGCILAFIWPPFALKKDISKKIVVSLDIIGISGFAVLMTLFFIVGDQDQWIYNGGFYIISFATLFIIAIAVHPSSLFAKFLSMKPLLIIGKRSYSLYLWHYPIIVFVNSYYVQGQIPVYVYIIEILLTALMAEISYRFIETPIRKKGFKAFAFLPKKKGQFARTVLVILLLVPSIVVLSGQFDALGKQHEAEKKEKKTEFKTTKKKVVKKDKQEDKQTANSKEDIKKSSPLLIGDSVMVDIGNVFTKKIPNAQIDGKVGRQLVDATPIVKSQYKDYAKKGQKVVVELGTNGAFTKDQLNELLDSFGKADIYLVSIRVPRDYEGRINKLIYEAAEKRSNVHLVDWYKASAGHPEYFAYDGIHLEYAGSKALTDLIVKTMETHATNKK
The following text describes a protein:
Function:
Involved in the mineralization and structural organization of enamel.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MKQWMLVSSLLGICSALPLFPQHAGIPGMGSISLERTRQLGGLNIPPAVPQALPYSYADPFHSMWGRSFLPSHTFLWMTQGGPQRQDTQQYEYAMPVHPPPLPSLQTPIQFAEPRLPEQPFFQITNLIPTRQVQIPRYAIQPSIQQTFQQVEAHPPVDPQQQPLPAERQTHQIYPALHGTQQDPSQQLQQQSIYPSLYYMPYVANQGAAPARQGIVSSEEMQGGGFGAPAYRAPGPDLFAMDTRFGNSPLNQPGDYTVEDDTLGITEQPDVKGGANAGANPSGKGNNAVLLDGTQGGALPNANSHLFSPAGQSQGLSGLAQATAAPHATQGPFLPLDAADPSMPLDATMFPDLYTSNVGNEAGLAQVGQDAWHFQEP
The following text describes a protein:
Function:
Involved in sister chromatid and centromere cohesion during mitosis.
Subcellular Localization:
Nucleus. Chromosome, centromere.
Sequence:
MFYSQFILAKKGPLGTIWIAAHLERKLRKNQVADTDIGVSVDSILFPEAPIALRLSSHLLLGVVRIYSRKVNYLFDDCSEALLKVKQAFRSAAVDLPPEESTAPYHSITLPETFDLDDFELPDNEIFQGNYVDHHVSTKEQITLQDTMDGVVYSTSQFGLDERFGDGDTSQAALDLDEAVFQDKDVIGSDDEGVPGIDHNAYLDAAAPGIKDSMEGVSEAMPMDFNEEQVEDLAMNNEFIEDAQAPQTPGLVEVPNSSSVREQMACDDHMDVEDLNAEEGIKSSGELNANEMPKRGEDLSSEYNAPESAVTPVEVDKSQIDENVNTQNEPEEERAEHVHVTSPCCSHITTEMEDPGQVMNEAGANVVPDKPDAVPPLETPGEENRDHFAIATEVNQETDSSLQGDEQAYSRPDGQLNNAHETDEQLGNLTGFTDSDFPPPEKVLAVPNRQGDGNDFMVESTPDKEDPGTCNDDAGNNNITGKKRTFTESTLTAESLNSVESVGLIQSKRTADSVPDDDDLLSSILVGKSSFLKMRPTPVLEPATTKRLRSAPRSTATKRKVLMDDPMVLHGDIIRQQLTNTEDIRRVRKKAPCTVPEIVMLQRQALEDGLFKEPIFTGMSVELVSLHTEPYDLRGIMIIENDDRHASVGAVEDNECSVTAVEENKTEESSDPQAHPNDCEEQPGTAHTHPQEEQTINQQEELKDDNELAEKSDLEVLKEGNGAADEVNLVVIDDVSQIPSEEKLDRVEDLQVEESHENHDGEGGQDVCADPNEKSCTDVIEIAEGDTDINPIFNEMDLKVEDELPHEDEKTDASAEVSELGRDDQTPCDNTVGSTETGCLEAGDLSNMALENCNEPLVEANSDGLNPETESYNKYEPHNEMSNEEASMQNALDGEHTSRDGLMGDNDEMDTMENAHDTGFLNVDDDEVDEDHEEDDIQYDDETRLLENSGWSSRTRAVAKYLQTLFDKETENGKNVLVADKLLAGKTRKEASRMFFETLVLKTRDYIQVEQGKPYESIIIKPRPKLTKSIF
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAHENVWFSHPRKYGKGSRQCAHTGRRLGLIRKYGLNISRQSFREYANDIGFVKYR