lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis. Binds to the highly selective inward-rectifying potassium channel KAT1 and inhibits its activity. Functions as an essential negative regulator of inward potassium channels in guard cells. Essential for the efficient stomatal closure and opening in guard cells.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEEKPNYVIQVEEELPTLLRKATTEEMVGFDNYKENGHPFPHSISRFHPSHASTTTLNGQETSRSIDTMEAHHHNYNETTPWTHQRKPSISMPTSPNVLMISDPTTSLSSENHKNSGSTGKSVKFLSQPMTKVSSLYIESGNGDDDRRQSHDNHHHHLHRQHQSGHHQNQNQAANKLKDNRYNSFKTWSGKLERQFTRKPASVEPEAPNRNNQNLNTNEAMPVDRYYDALEGPELETLRPQEEIVLPNDKKWPFLLRYPISTFGMCLGVSSQAIMWKTLATAEPTKFLHVPLWINQGLWFISVALILTIATIYLLKIILFFEAVRREYYHPIRINFFFAPFISLLFLALGVPPSIITDLPHFLWYLLMFPFICLELKIYGQWMSGGQRRLSRVANPTNHLSVVGNFVGALLGASMGLREGPIFFYAVGMAHYLVLFVTLYQRLPTNETLPKDLHPVFFLFVAAPSVASMAWAKVTGSFDYGSKVCYFIAIFLYFSLAVRINFFRGIKFSLSWWAYTFPMTGAAIATIRYATVVKSTMTQIMCVVLCAIATLVVFALLVTTIIHAFVLRDLFPNDLAIAISNRPRPKQNSQHRWLDQLRNVSSENIENYLKFTDSDSSQSNDVEACNGKTQESDSS
The following text describes a protein:
Function:
Required for normal heme biosynthesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MQDSGPLVPSHWIGFGYAALIASGGITGYAKAGSVLSLAAGLLPCALASLGAFQLSQDLRNIWVFLATSGALAGIIGMRFYDSGKFAGASLSMVAKLGITVLNMPRQ
The following text describes a protein:
Function:
Catalyzes the glutathione-dependent reduction of S-glutathionylquercetin to quercetin.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAPSFIFVEDRPAPLDATSDPPSLFDGTTRLYTSYVCPFAQRVWITRNFKGLQEKIKLVPLDLGNRPAWYKEKVYPENKVPALEHNGKIIGESLDLIKYLDNTFEGPSLYPEDHAKREFGDELLKYTDTFVKTMYVSLKGDPSKETAPVLDYLENALYKFDDGPFFLGQLSLVDIAYIPFIERFQTVLNELFKCDITAERPKLSAWIEEINKSDGYAQTKMDPKEIVEVFKKKFM
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus envelope.
Sequence:
MLPQDDMTDEMKSLASRLEDTTQAFYDLALIVYNLEDTTPSDAIPESLDTLIRDLKSLPDISRKVNNLIPQDVLEYIEQGRNPDVYARQFSELVQKDNQYVNGKLYAIEGFQKAFAEEIKQAYPEVSSVVDKILNEGKVESTVS
The following text describes a protein:
Function:
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Sequence:
MSSFAPNVKICEDISHISSAARDIILAAIDARVDKSAPVVLALSGGSTPKRLYEELHEKDLTLLQQHAVQFILGDERLVATDDEQSNFSMATKALLRDVPISDVIAIEPSAALATSKDEKGGVDGAWAVAQDYEKKLRNRLPCTQVNGTDMSVPIVDIVLLGFGADGHTASIFPDSVAATDESHVVSVSFPSPTMNPKVWRVTLSKTVIQHAKHVVVLACGKDKNWVVHGVLAEAPTGPLPVSRFLRECRGSVTMLLDAGSGEGLSA
The following text describes a protein:
Function:
Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA.
Sequence:
MSSSDLGRGFKQGRGTGDSGQSSLYNNERRWKDDDTFNALGATDELSSFLGVCGASAQNDGSMSDVVETLTRLQCCLQDVGAHLATPPKNSSERKQKKTAFDIAMVEWINAEIDRYGDALPAIRQFILSGGGMTSAQLQYSRAICRRAERSIVPLMRDEDVDPMALKFLNRMSDLLFVLGRTACMRNKNEELTYLRPDSFTNLKWDRKSLHEKK
The following text describes a protein:
Function:
Required for nuclear membrane fusion during karyogamy.
Subcellular Localization:
Endoplasmic reticulum membrane. Nucleus membrane.
Sequence:
MALVISRADVTLEALQLLETLNSSSSCNKLAATKLVSSCKSIGRNAESTGGSDTYLTLERVRSLYAARLAICELREAGIPTPSACRSVDHFQPPRRGLWGRHPRNSFVTDIDNMPKSDFEPCIRVLESRPQWWTSYSNSKQNAVIICQASRIEIDKEDILETYNSILHSSAKLSDGLHEALRTAAEESTRSRAFLQSTELLRKEMLREMQESTSTLLERMFHNLETRLGLLTEVISSTLHRFRLGLSSLEGVSQSLAIPVRNAEKHNELALSLQSKLKSITKDDITELRQGVENIDSSLEWLYARIVRIYEEEASVSERLRGIESSLAEFQQRADNLDKVQQRQYEIAVAQAQAQQVLEENMRISKGILDQTMSTAANLQAMIGETADTAEAIRHYIPTLPPIKCTDLIYCAFDFLKFQRPCEWLAFSMCHHKRYRARPVRDAKASTGLRIGRVICHPLTGFVTIRARQLQGQAYSLSNLAFPHASSMHRTIACAMRSTAVRYIFG
The following text describes a protein:
Function:
Regulatory subunit of mitochondrial acetolactate synthase, which catalyzes the first of a series of common steps in the biosynthesis of the branched-chain amino acids. Stimulates activity of the acetolactate synthase catalytic subunit ILV2 seven- to tenfold and confers sensitivity to inhibition by valine and activation by ATP.
Miscellaneous:
MISCELLANEOUS: Present with 15800 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRSLLQSGHRRVVASSCATMVRCSSSSTSALAYKQMHRHATRPPLPTLDTPSWNANSAVSSIIYETPAPSRQPRKQHVLNCLVQNEPGVLSRVSGTLAARGFNIDSLVVCNTEVKDLSRMTIVLQGQDGVVEQARRQIEDLVPVYAVLDYTNSEIIKRELVMARISLLGTEYFEDLLLHHHTSTNAGAADSQELVAEIREKQFHPANLPASEVLRLKHEHLNDITNLTNNFGGRVVDISETSCIVELSAKPTRISAFLKLVEPFGVLECARSGMMALPRTPLKTSTEEAADEDEKISEIVDISQLPPG
The following text describes a protein:
Function:
Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
Sequence:
MANVGLQFQASAGDSDPQSRPLLLLGQLHHLHRVPWSHVRGKLQPRVTEELWQAALSTLNPNPTDSCPLYLNYATVAALPCRVSRHNSPSAAHFITRLVRTCLPPGAHRCIVMVCEQPEVFASACALARAFPLFTHRSGASRRLEKKTVTVEFFLVGQDNGPVEVSTLQCLANATDGVRLAARIVDTPCNEMNTDTFLEEINKVGKELGIIPTIIRDEELKTRGFGGIYGVGKAALHPPALAVLSHTPDGATQTIAWVGKGIVYDTGGLSIKGKTTMPGMKRDCGGAAAVLGAFRAAIKQGFKDNLHAVFCLAENSVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACKDLGADIILDMATLTGAQGIATGKYHAAVLTNSAEWEAACVKAGRKCGDLVHPLVYCPELHFSEFTSAVADMKNSVADRDNSPSSCAGLFIASHIGFDWPGVWVHLDIAAPVHAGERATGFGVALLLALFGRASEDPLLNLVSPLGCEVDVEEGDLGRDSKRRRLV
The following text describes a protein:
Function:
Serine hydrolase required for the maintenance of steady state level of non-polar and polar lipids of lipid droplets and thus plays a role in maintaining the lipids homeostasis. Exhibits both esterase and triacylglycerol lipase activity.
Subcellular Localization:
Lipid droplet.
Sequence:
MNMAERAEATKSWSCEPLSGKTLEEIVQNAENAADLVAYIRKPEVDLDFRLKFIAEHEEFFNVQLSDRNSRIRTCHNLSDKGIRGDTVFVFVPGLAGNLEQFEPLLELVDSDQKAFLTLDLPGFGHSSEWSDYPMLKVVELIFVLVCDVLRKWSTAVPNNDNVNPFNGHKIVLVGHSMGCFLACHLYEQHMADTKAVQTLVLLTPPKAHIEQLSKDKHIIQWALYGVFKLPWLFDVYRNKFDQVKGLQSSGIKQYFYQQGDDVKLKYRKFWQFKNNISNKSRTIIGYLLGWETVDWVKFNGVLTQTDMKQKIIIFGAEKDPIAPIENLEFYKQTINKECLRKVIILPDCSHNLCFDRPELVCENFQREVIDNSKL
The following text describes a protein:
Function:
May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4-benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NADPH is the physiological reductant rather than NADH.
Miscellaneous:
MISCELLANEOUS: Catalysis proceeds by a classical ping-pong bi-bi reaction mechanism; MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MVTRIVILGGGPAGYEAALVAATSHPETTQVTVIDCDGIGGAAVLDDCVPSKTFIASTGLRTELRRAPHLGFHIDFDDAKISLPQIHARVKTLAAAQSADITAQLLSMGVQVIAGRGELIDSTPGLARHRIKATAADGSTSEHEADVVLVATGASPRILPSAQPDGERILTWRQLYDLDALPDHLIVVGSGVTGAEFVDAYTELGVPVTVVASQDHVLPYEDADAALVLEESFAERGVRLFKNARAASVTRTGAGVLVTMTDGRTVEGSHALMTIGSVPNTSGLGLERVGIQLGRGNYLTVDRVSRTLATGIYAAGDCTGLLPLASVAAMQGRIAMYHALGEGVSPIRLRTVAATVFTRPEIAAVGVPQSVIDAGSVAARTIMLPLRTNARAKMSEMRHGFVKIFCRRSTGVVIGGVVVAPIASELILPIAVAVQNRITVNELAQTLAVYPSLSGSITEAARRLMAHDDLDCTAAQDAAEQLALVPHHLPTSN
The following text describes a protein:
Function:
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MKYLKILIIVTIFFFLLINVINCIDRKEIVQKEVKIKFKNLKSTLIKKYSESNMEKIQKHLKHILVERVADTPNHKKVREYIISQFDQLYWDIELDSFKDNTPFGEKTFTNIIVTSKFVNDDDEDDIDTKESNGNISSEPPKTLVLSAHYDSKYFKEFKFFGATDSAVPCSMLIDLAISLQSEIKKSKKKLMIIFFDGEEAFKEWSDTDSLYGSRHLANLLLDKKVITKDNEDLPISSSFYNTVEAFILLDLLGTPNPRFYMFNKKTESLFKKLSDIEDKLSLKRFISPKANKYFQNHFIGSDIQDDHIPFLNYVPTLHIIPYPFPNVWHTEKDDESCLDKNTIEDLSKIFKIFVGSYLI
The following text describes a protein:
Function:
Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTTPSKSSNKRFRDNESEVDETGSQIEKQVNATASTSTSRPALSSHESEGSSVMKTKKKKKAQTPGIVFISRVPPGMTPQKIRHLMGRWGDIGKVYAQRRDAPGGYNPNSANQKKQKHASANFTEAWVEFLDKSVAKTVASMLNAQVIGGKKGDRWRDDIWTMRYLSGFKWEMLGEQIAYERQAHQARLRTEITRAKTEQNEYLKNVELARTLEKRKAKKAAAGGPSESAPNQDAHSRSYKQRNVVEKPKTLEGQGMDGVLNNIFG
The following text describes a protein:
Function:
Positively regulates mitochondrial complex assembly and/or stability. Increases mitochondrial membrane potential while decreasing mitochondrial reactive oxygen species (By similarity). Increases mitochondrial respiration rate. Increased mitochondrial respiratory activity promotes myogenic differentiation which facilitates muscle growth and regeneration. Increases mitochondrial calcium retention capacity. Plays a role in maintenance of cellular lipid composition through its interaction with cytochrome b5 reductase CYB5R3 which is required for mitochondrial respiratory complex I activity. Interacts with the mitochondrial trifunctional enzyme complex (MTE) and enhances fatty acid beta-oxidation. Not required for MTE formation or stability. Modulates triglyceride clearance in adipocytes through its role in regulating fatty acid beta-oxidation and lipolysis.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Note=Preferentially binds to cardiolipin relative to other common cell membrane lipids.
Sequence:
MADVSERTLQVSVLVAFASGVVLGWQANRLRRRYLDWRKRRLQDKLATTQKKLDLA
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MATSALLRALRRPSSEAALRLAASVRVQGVTGYRHLNNRNLSVFNEFSKQLKGEAKSNPEFQKSMKEFSEKLSGVKEDLKVRTKQTAETIYKSVDDVLTEAEATSKKVTANVKEKMSAATEEVKESFRLGKEDTSSCKDGSPETSKHEYSETSSHSDDKSQAGTSGYTLFNKLRSTLSSASPVLSGAFAKLRDTRVSTYAKQGYEIFKDELSSSSSRKKRNHARHASAGTVEKSTRTELVIVPTKKSVLGEKWEAFKNKMRGHPAYKRVNEYTKPVVNIGQEVAEDVRERWETSDNPVVQKIQDLNESIFEETATAVSFREIRQRDPSFSLPDFAGDVQEMIKPVLTAYSKGDVKTLKKYCTKEVIERCKGERDAYASQGIFFDHKILHISDADVRETKMMGSTPIIIVGFQTQQIYCVRDREGQVTEGGQDTIQTVFYAWAMQLMDSDEVPEEESYYPVWRLREIQQVGIKALI
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MVRACEARRLGGLRALFKYTQIVADNRPPQENDWPYNNPPGQNESSIVGAPSLEDQLRAASASPSVATQPLPPTKPTTQKDPTHAVKSLSPASRTGPSSPATAADTGNQVANNIADDARAASSNGTSPAPAVQHAVGVDASVSDGPSIAPSAVNTPDVDLKDEAATAESKPKAPQVVHLPPKDVQEARLHETERKLEKIAEKERKDDFHANGPTDLISSPSSTVGPYSQATPHAPHHSPDTSPDTESFQERPRATLQTTESLDPAAQQVKEDHERALQKEMTEARERARGTESPTPDIEKQIEDEQAIRLARDGKSRLAGSTTEQGTGLMSHAKDIARDAAPAGERFVEVRASQDPAADSLPTPTTTAPEPSTVDPEATDRETNKVAEADSHPTPPAELDVEMGDAPTSTNPRSPPVHPSRPDRMTTRVSSGAMRQKSVSEILAEKAAPKTVLTPRSSNLSTSASPPRPKTRDPRSKEVVVFAKKTPRRGSKALQAYDEDYASLHGASEDSSRDYLEGLFKYQAHHPPRSIPLQELVASARKTVTTAGTLAMHREHQDYKILKRVYQLQNANRWSLRQLQKSVEPERPFTHHDQLLLEMKNISTDFQEERRWKEALAASFAEWCAKYVNSSPEERATLRVNVRKPIAAKQVEHHDEDMDDAPTPDLVQSHAHETESESFADEDELRTPLSANPPTGLFSLGFNDVVMKIHRTPASDTMFRELPFYEPMLEGSSDGNPFSVAEPPILPVSKYVTGKLVSQIRGPPRKRSRYDYDSEDEPSTPPSRSGTSAEHSMPSTPGRRLFCRNDLPPEMTDVALFNAENKHVRDRLQAAHQFRPPTEFNMPSVAFFEHRIPSQWLWEEDQKLRSLVKEFTFNWSLVSQQLSLPSMFVSGSGRRTPWECFERWVQLEGLPAEMSKTQYFRTYQGRLEQANKTVFAQYQAQQQQQQQQGAAPAQPRRRPTTTPIRVERRRENRYLAIIDGMRKLARKRESAAHKQAESQKAAALRKAHEPAPPKNTVHTPQEFSRLKWEREEKLKLRQQQQEMAVRQQMVQQRQQAQMAAQGGMPNGANQMLRNGTSMGNPTGSAHMANSASQQGQNAAAMAARAHQGQQGMQANFGNGNMAGMPMGTSGVPQAQMQGNMQNGQRMAPPNQMQMAMQRGQFPNSAQQQFQLQQQQHQLGMGNNLTPGMGLNSNIPNANMMASMSNQNMNGNINGNINATMNGLPNNVGSPRPNQGNGNMQTPSRPLSSGHMPNILHLQNVYKVQHPEWTNEQCQKAASEHLQKSMAKTQRTQAMNAAAGSSGMSPSPQIGNNQYLPQNGSMANSPQPGNNPAVANYQQQLVQQQRMMQQSRQQAGSPGMNAARPASRSATPQNPQMLQSPGMQQAQVNRSS
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MSIMHTLFSKGNEEIAENPVATLSTTVPCWSNGLVSQSDPFGQLKSASVEHSELPKGNATEFTIFSVSPSGDWKSSGYGQNQSNIQAAATSANMDYRCHFELGFGQSLISAKYPYGGEQSVGLFSAYGPQLSVLLLSHSTSFQSLELYDGLGRVMLPLNLASDEGPIFVNAKQYHGILRRRKSRAKEMEKKALKPRKPYLHLSRHLHAMRRPRGCGGRFLNTRKMNGIMKGGKTNDTVKTGDVHSFYSTGSQNSEVLQSDSSNLSSPKETTGSRFCHSSEVTNMYSRGNLDPFLFQDLRPSVQAIPDMMNTGHGILMAGKWVSAADSCCNLKV
The following text describes a protein:
Function:
Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.
Subcellular Localization:
Nucleus.
Sequence:
MKAGCSIVEKPEGGGGYQFPDWAYKTESSPGSRQIQLWHFILELLQKEEFRHVIAWQQGEYGEFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKLVMPNYPFINIRPNGEPTLWVE
The following text describes a protein:
Function:
Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK. Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis.
Subcellular Localization:
Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
MSKLKVISEKSLTNNSRIVGLLAQLEKINTESTESDTARYVTSKILHLAQSQEKTRREMTAKGSTGMEVLLSTLENTKDLQTTLNILSILVELVSAGGGRRASFLVAKGGSQILLQLLMNASKESPLNEELMVQIHSILAKIGPKDKKFGVKARINGALNITLNLVKQNLQNPRLVLPCLQLLRVYSANSVNSVSLGKNGVVELLFKIIGPFSKKNSGLMKVALDTLAALLKSKTNARRAVDRGYVQVLLTIYVDWHRHDNRHRNMLIRKGILQSLKSVTNIKLGRKAFIDANGMKILYNTSQECLAVRTLDPLVNTSSLIMRKCFPKNRLPLPTIKSSFHFQLPVIPVTGPVAQLYSLPPEVDDVVDESDDNDDIDLEAENETENEDDVDQNFKNDDIETDINKLKPQQEPGRTIEELKMYEHLFPELVDDFQDYDLISKEPKPFVFEGKVRGPIVVPTAGEEASGNPGNLRKGIVRTNVSPKADESDKKPTCVDLAKEDIKDNDRTSQQQLGDQNRTISSAQGLNNDIVKALDRITLQNIPPQTAPGFTAGAKKDYSLPLTVLTCTKACPHMATCGNVLFEGRTVQLGKLCCTGVETEDDEDTESTSSVEQASVEVSDGPTLHDSDLYIEIVKNTKSVPEYSEVAYPDYFGHIPPPFKEPILERPYGVQRTKIAQDIERLIHQSDIIDRVVYDLDNPNYAIPEEGDILKFNSKFESGNLRKVIQIRKNEYDLILNSDINSNHYHQWFYFEVSGMRPGVAYRFNIINCEKSNSQFNYGMQPLMYSVQEALNARPWWIRVGTDICYYKNHFSRSSVAAGGQKGKSYYTITFTVNFPHKDDVCYFAYHYPYTYSTLQMHLQKLESAHNPQQIYFRKDVLCETLSGNTCPLVTITAMPESNYYEHICQFRNRPYVFLSARVHPGETNASWVMKGTLEYLMSNNPTAQSLRESYIFKIVPMLNPDGVINGNHRCSLSGEDLNRQWQSPNPDLHPTIYHAKGLLQYLAAVKHLPLVYCDYHGHSRKKNVFMYGCSIKETVWHTNDNATSCDVVEDGGYRTLPKILSHIAPAFCMSSCSFVVEKSKESTARVVVWREIGVQRSYTMESTLCGCDQGKYKGLQIGTRELEEMGAKFCVGLLRLKRLTSPLEYNLPSGLLDFENDLIESNCKVTSPTTYVLDEDEPRFLEEVDYSAESNDDLDTELVENAGDYEPSAQEEVLSDSELSRTYLP
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
Sequence:
MTRNIGLKVKEPKRECEDKNCPFHGELAIRGKLFDGKVTGSKAKQTITLQKDAPVYFNKFKRYARGKSSIHAHVPGCIDVESGDNVLTAECRPISKSVSYVVVEVRS
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MASTSASFSVSEAPATDVAKRMAVSKNAADDMMRVLSIYDARLLPMSPAEGEPAGEAYGCDEREEQEEEAFAAAEDVIRRCDSSSSSSGMADYLYAVDDALAAASLQGGLASRAAEAVQAAMPRLEEEARALLCSSSARRLSLSSDDLDDAATPPDASPRLSPRAAASVRGVADRMLRAGYGPELAQVYVTTRRDAITEAVAHQLGAAEPVAIEEVLRMEWQVLDQKMRRWNHAIRAVVRTLLAGERRLCDEVFASDEELGHECFADVSRGCVLQLLGFADAVAMSARATEKLYRTLGMYEALADVAPELEALFTGDARELFSAEVSAVAARLGSTVRRTIEEFGSAIQGESSRRPVQGGEIHPMNRYVINYCGLLADCRSTLDMILVNTADAVDGDEATGGGGGATSTPSGRCMLELLTRLLRKMDEKSCLYDDAGLKHIFLMNNLYYIVQKVMDSPLRELLGDDWIRRHRGQIRQYETGYLRASWITVLSVLRDDGGSAAPTVKDKARSFNAAFEELYRNQTAWKVIDPQLREELRIAVSERLIPAYRSFLSRPRPQTGSSSGGSRHSASKHVKYTLEDLEDYMLDFFEGVQKFVK
The following text describes a protein:
Function:
Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MARGWVRPSRVPLCARAVWTAAALLLWTPWTAGEVEDSEAIDTLGQPDGPDSPLPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRVIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGLKTITATGVLYVRLGPTHSPNHNFQDDDQEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTQLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLENDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGADYRGMASTTKSGHQCQPWALQHPHSHRLSSTEFPELGGGHAYCRNPGGQVEGPWCFTQNKNVRVELCDVPPCSPRDGSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLISQHKQAKLKEISLSTVRFMEELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRSWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYMAPKQKAQPFPQPQFIPMKGQIRPLVPPAQLYIPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSVADRAALLSEGTEDAQNIAEDVAQSPVQEAEEEEEGSVPETELLGDNDTLQVTEAAHVQLEA
The following text describes a protein:
Function:
As part of the KICSTOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
Subcellular Localization:
Lysosome membrane.
Sequence:
MCDPQRDEELRPVPKERAVLESFFTQLGMFWFDRAKDYVEKEKDASKSAGAIWGSLLAALAHLAAAEKAYHNMTFLGQKLGGQSFFSRKDSIRTIYTSLHNELKKVVSMGRHAPGGSTPNLEELLPHLSEQLCHFTQARMEIADFYEKMHTLGSQKTVNSEELVGALDSILQKYSSRFHHPILSRLESSFQVEVDVLTQLLRCQAQISEWHFLPSLLNLHGAHSKLQAWGQVFERQRETRKHLFGGQSQKAVQPPHLFLWLQRLQATLLAKFSFYFHEALSRQTSQSEMKTLTARTSLDYFGKISGFIRKYDASNVSLVFDNRGSESFQGHGYHHPQSYREAPKGVDQFPAVVSLPGGERPVTHWPNVIMIMSDRSTELNTLDKVVHFYDDKVQSTYFLARPEPHFTIVVIFDGRKSERDSYIVAFLQELIGSLRNSKPFTSLKPGSKG
The following text describes a protein:
Function:
This protein is involved in control of the biosynthesis of isoleucine, leucine, and valine.
Sequence:
MTTSMLNAKLLPTAPSAAVVVVRVVVVVGNAP
The following text describes a protein:
Function:
Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Note=Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes (By similarity).
Domain:
The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns(3)P).
Sequence:
MPNSVLWAVDLFGRVYTLSTAGQYWELCKDSQLEFKRVSATTQCCWGIACDNQVYVYVCASDVPIRRREEAYENQRWNPVGGFCEKLLLSDRWAWSDVSGLQHRPLDGVALPSPHWEWESDWYVDENFGGEPTEKGGWTYAIDFPATYTKEKKWNSCVRRRKWIRYRRYKSRDIWAKIPSKDDPKELPDPFNDLSVGGWEIAEEPVGRLSVWAVSLQGKVWYREDVSHSNPEGSSWSLLDTPGEVVQISCGPHDLLWATLWEGQALVREGINRSNPKGSSWSIVEPPGSDNGIMHVSVGVSVVWAVTKDWKVWFRRGINSHNPCGTSWIEMVGEMTMVNVGMNDQVWGIGCEDRAVYFRQGVTPSELSGKTWKAIVAARECDRSHSGSSSSLLSAGCFFGDEVRGSGESAPSDTDASSEVERPGPGQTLPAEPLDDSKNAMENSASGPGAGRTTEDTVEDACPAEGSREARPNTHPGPATTPAELPWTNIDLKEPKKVPSHSAAGFPETTSLSSLGLFPLGLEEPYGVDDHPLRAWVSGGGCMVEACAVPRWFTVQAGLSSSVHMLSLSITPAQTAAWRKQIFQQLTERTKRELENFRHYEQAVEQSVWVKTGALQWWCDWKPHKWVDVRVALEQFTGHDGARDSILFIYYVVHEEKKYIHIFLNEVVALVPVLNETKHSFALYTPERTRQRWPVRLAAATEQDMNDWLALLSLSCCESRKVQGRPSPQAIWSITCKGDIFVSEPSPDLEAHEHPLPCDQMFWRQMGGHLRMVEANSRGVVWGIGYDHTAWVYTGGYGGGCFQGLASSTSNIYMQSDVKCVHIYENQRWNPVTGYTSRGLPTDRYMWSDASGLQECTKAGTKPPSLQWAWVSDWFVDFSVPGGTDQEGWQYASDFPASYHGSKTMKDFVRRRCRARKCKLVTSGPWLEVPPIALRDVSIIPESPGAEGSGHSIALWAVSDKGDVLCRLGVSELNPAGSSWLHVGTDQPFTSISIGACYQVWAVARDGSTFYRGSVYPSQPAGDCWYHIPSPPRQRLKQVSVGQTSVYALDENGNLWYRQGITPSYPQGSSWEHVSNNVCRVSVGPLDQVWVIADKVQGSHSLSRGTVCHRTGVQPHEPKGHGWDYGIGGGWDHISVRANATRAPRSSSQEQEPSAPPEAHDPVCC
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.
Subcellular Localization:
Cytoplasm.
Domain:
The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain.
Sequence:
MRLSDYFPESSISVIHSAKDWQEAIDFSMVSLLDKNYISENYIQAIKDSTINNGPYYILAPGVAMPHARPECGALKTGMSLTLLEQGVYFPGNDEPIKLLIGLSAADADSHIGAIQALSELLCEEEILEQLLTASSEKQLADIISRG
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Domain:
Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence:
MDPNCSCPTGGSCTCAGSCTCKACRCTSCKKSCCSCCPAGCAKCAQGCICKGASDKCSCCA
The following text describes a protein:
Function:
May sequester excess cytosolic iron and manganese into endoplasmic reticulum to reduce metal ion toxicity. Not essential for the accumulation of ER body components, including PYK10.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: May be due to an intron retention in isoform 2.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Located in ER bodies.
Sequence:
MDPTMNPTPTPSSAGNSVCTDELTNLPPEDSPLDSEKDDSVDFSQEQGSESNEAIDTENGSRSVDKNQYSETEVVVRAKDLQTEPDSLDDDVEIVIKNQHKYYIYCPCCGEDITKTVKLVKISDPKHTKDHDKAVDSDTENGSKSKDKNTKVPSWFSDFIQPLFSSEDRGKKGVVDSELLGTYEDLGIIGEEPSIDVSNEKDRPSFPKWYLDVFAWLFLCIIIALSVLSTSPPPFIQPHLQLPSMPTLRMPSASVLLLLPTSAVLLLFIISMRSRFTPRYHKEKGEVVPKSTDSKSHDDQAANTDQDFDKKTDNKRNRLTPIYPSSLEKPSKQTVNKETQNHDKEAADPDQDVDKETENQKSHLTPIYPSPLEQPSKQIINKETQTEPMLPPNAQSEIPNSVEPRKGGNKVEILKSIVYGGLTESITSLCTVTSAAASGASTLNVLALGVANLSSGLLLTVHSLQELINEKPRKQTNTDDSPEEGEGEEDRYEEVLGRREYSRIHRVIAISSFVIFGLIPPLVYGFSFRKKMEKRQEYKVLAVYAVSLLCIVLLSIAKAYVSKKRDYVKTLFRYTTTATTASGFSQFVGYLVSQWLEKSGFYDDSPETQRV
The following text describes a protein:
Function:
Catalyzes the reduction of a single double bond in the isoprenoid tail of menaquinone (MK-9) in M.tuberculosis, likely the beta-isoprene unit, forming the predominant form of menaquinone found in mycobacteria, MK-9(II-H2). Is required for M.tuberculosis survival in host macrophages.
Sequence:
MSVDDSADVVVVGAGPAGSAAAAWAARAGRDVLVIDTATFPRDKPCGDGLTPRAVAELHQLGLGKWLADHIRHRGLRMSGFGGEVEVDWPGPSFPSYGSAVARLELDDRIRKVAEDTGARMLLGAKAVAVHHDSSRRVVSLTLADGTEVGCRQLIVADGARSPLGRKLGRRWHRETVYGVAVRGYLSTAYSDDPWLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTSRRPADLALRPLISYYTDLRRDEWGFTGQPRAVSSALLPMGGAVSGVAGSNWMLIGDAAACVNPLNGEGIDYGLETGRLAAELLDSRDLARLWPSLLADRYGRGFSVARRLALLLTFPRFLPTTGPITMRSTALMNIAVRVMSNLVTDDDRDWVARVWRGGGQLSRLVDRRPPFS