lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MAPSSLLLSVGSLITSSLVSATALEARQSQTYQLAESWQGESFINDWNFFDGADPTNGYVTYVNQSFAKQSGLVKVTESGSFYMGVDYESTLNPNGAGRESVRIESKNYYTEGLYVIDIEHMPGSICGTWPAFWSVGKNWPNDGEIDIIEGVNLQKANKIVLHTSGSCDVSGSNDMTGTLSSSECGEASGTVGCVVKGTNGSSGDPFNESGGGVYAMEWTDTFIKIWFFPRSQIPASLASGNPDTSSFGTPMAHLQGSCDFAERFKAQKLIIDTTFCGDWAGNVFAESTCPMSDPSSPMQSCVNYVAQNPAAFKEAYWEINSIKIYQYGVSAASSAAVSQATASKVEGTRVSAQAANTATPTVPAPVETTTVPQPAQTNTVATSAADHATPSSAETTTVPAATGAPSVSATEGGDSELESTSTVYVTSTTTICPVAESSSAAAAGGKEDAPSNGTSGAEVAATSVAAAAPAAATSGHPGADAIANSAAATSTDAQSESATSRLTAGALSEIPTAPPEPVSQAVSTGSFDDSDTAQGDSEEQGSIASASVAPSTIPVPASSSAAALGGSSIASSFASSRLIPRPTGSSTAASATAIATWSPTAGESASGTAKESATLTTPSEVFFTPGLSNGANRMSVGLSGLIGVMFIAALA
The following text describes a protein:
Function:
This colicin is a channel-forming colicin. This class of transmembrane toxins depolarize the cytoplasmic membrane, leading to dissipation of cellular energy; Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGSNGADNAHNNAFGGGKNPGIGNTSGAGSNGSASSNRGNSNGWSWSNKPHKNDGFHSDGSYHITFHGDNNSKPKPGGNSGNRGNNGDGASAKVGEITITPDNSKPGRYISSNPEYSLLAKLIDAESIKGTEVYTFHTRKGQYVKVTVPDSNIDKMRVDYVNWKGPKYNNKLVKRFVSQFLLFRKEEKEKNEKEALLKASELVSGMGDKLGEYLGVKYKNVAKEVANDIKNFHGRNIRSYNEAMASLNKVLANPKMKVNKSDKDAIVNAWKQVNAKDMANKIGNLGKAFKVADLAIKVEKIREKSIEGYNTGNWGPLLLEVESWIIGGVVAGVAISLFGAVLSFLPISGLAVTALGVIGIMTISYLSSFIDANRVSNINNIISSVIR
The following text describes a protein:
Function:
Lacks adenylate kinase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
METLLHSEILKKYKEETNEYIKKKNVEKLFDIILKNVLINKPDNIYLYIYNNIYSFLLNKIFIMGPPVLKITSMLSSHISEFFNYYHISLPILIQQYKLNKGESSNNKIIVNDEIISFILKENIHNLDSKKKKGYIVEGYPNNNLQAYSCLKYLPSHVFVLYADEEYIYKKYEEENDIAIFSYTQKKDYDINEPHEINNIDVKPLKDQVLSYIRNISDMLTILGTNKKVLNLHDFNDQMLIDHVKNEVSKNKDEWDSTLNGDI
The following text describes a protein:
Function:
Essential cell division protein.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Sequence:
MTEHNEDPQIERVADDAADEEAVTEPLATESKDEPAEHPEFEGPRRRARRERAERRAAQARATAIEQARRAAKRRARGQIVSEQNPAKPAARGVVRGLKALLATVVLAVVGIGLGLALYFTPAMSAREIVIIGIGAVSREEVLDAARVRPATPLLQIDTQQVADRVATIRRVASARVQRQYPSALRITIVERVPVVVKDFSDGPHLFDRDGVDFATDPPPPALPYFDVDNPGPSDPTTKAALQVLTALHPEVASQVGRIAAPSVASITLTLADGRVVIWGTTDRCEEKAEKLAALLTQPGRTYDVSSPDLPTVK
The following text describes a protein:
Function:
GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades. The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form. May play a role in synaptic vesicle exocytosis (By similarity). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm. Cell membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=Interaction with PKD1 promotes location at the cell membrane. Interaction with RGS7BP promotes location at the cell membrane.
Sequence:
MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYVEYDPFLAPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIREVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGKSLTSKRLTSLVQSY
The following text describes a protein:
Function:
Involved in the regulation of homocysteine metabolism.
Sequence:
KLGTLSPQTKHISKEEEEKCTLGILERLDAGEVVVGDGGFLLTLEKRGYVKAGLWTPEAVVEHPNAVRQLHMEFLRAGSNVMQTFTFSANEDNMESQWEAVNAAACDLAQEVAGKGDALVAGGLCQTSLYKHHKDEDRIKKLFRLQLEVFVRKNVDFLIAEYFEYAEEAVWAVEVLKESGKPVAATMCIGPEGDMHGVTPGECAVKLVKAELGRQRGANLQGASIIGVNCRFGPWTSLKTMRLMKEGLQAAGLKAHLMVQSLVFHMPDCGKGGFVDLPEYPFALEPRVATRWDIQKYAREAYNLGIRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLNMHTKPWIRARARREYWENLLPASGRPFCPSLSKPDV
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MIQVEIVSPQGMVYSGEVESVNVPTVEGEVGILENHMYLMTLLKPGLVYFNGDDKNGIAVTYGVLDVTPQKVLILAEEAYEVGKLPPASKLKEEFEEAVKKMATAQTMEELKEWEKEAEKARTLLELVEKYR
The following text describes a protein:
Function:
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.
Sequence:
MKDDTIRKVALDIGNNRIKLLVGEMSSDFQRLAVTNYVKTRSNGISKSLIENPEALAIALKEAVSKAESVESPITRLSLALGGSGIHSATVNVKTSFPEKEIEKTDMDNLLRQAKRQIFGGREGQYRILYKEVYNKKIDISSGIVKEPIGMVGKELQADIHLVYVDDNYVQKFIQVVNKIGIDIDRIYLNSYASAKGTLDDETKKMGVAHVDIGYGSTSIIILKYGKVLYAKTKPVGEMHYISDLSIILKIPKEGAEEILNKLKNKQIEADNTIRYGAKKVTLREIKDIILARTGDIIDFITTTIDESGFNGHLTKGIVLSGGAVEIDGVSEQIASRSGYLTRRMLPIPLKGLKDAFYSDAVAIGIFLEDMEREYRAYLEESRQPAPTVKEKKEIIKEETTSNNKINDKKMDRKEEIDSFLEDVEEIEPKKEDGKIKSFFKWFGELF
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MDDDEQKGYTWEAGYAEGLNINDVLVEDEGGSIEKSIAKYVADSKRKARLTKRPERIRLGIMRHVMIVIDCSRFMTSKAMPPSRFVVVMKALQTFLDRFFEQNPIAQIGLITCKDRKADRLTMMTGNIRVLKESLNTLTEAFCGGDFSLQNALQLACANLKGMPGHVSREVVLVISALSTIDPGNIYSTIETMKRMNIRCSAIGLSAEMFVCKEMAKATKGEYSVALDPDHLQLLFSKHTLPPSSAKSSECNAIHVGFPHHELITTRSFCVCHPDTKPISSRGFICTQCGARHCSIPAECPVCKLTLVAAPQLARAFRHLQPLSAFEQIEVTRGFCYACETRLSGEGFRCGSCQLVFCLDCDTLLHESLHVCPGCN
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB39.
Subcellular Localization:
Secreted. Note=Following 6 weeks of nutrient starvation.
Sequence:
MTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTFWPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion membrane.
Sequence:
MIKLGALVGTSAVTAALISKKTIFAAAPQKDSKIKLSELPLYDVKKSEPTFIVEEENISMLRSSISDARKFVWEYVGSMEGMIATIKDKYNVAESHTKETLAYIHEDSAVLPRIAIITVAGLGGVIAGYRGGIFKKIIYSSISVATAAAVCYPKEASDFAQQGWDYLKETTDDIWGSADKKSDTVNKKVGSEKTGETDKNVNNDVKESNVHADSNKDMYSNRST
The following text describes a protein:
Function:
Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Domain:
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRPAGAPTNRWREELSHMKRLPPLPGRPYDLAATVATDLESGGAGAACSSNNPALLARRETEEFNDLLDLDFILSNSLTHQESVAATVTTSASASSSSSPASSGPASAPSTCSFSYPIRAGGDPGVAASNTGGGLLYSRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLTTPGSEYSSPSVISVSKGSPDGSHPVVVAPYSGGPPRMCPKIKQEAVPSCTVSRSLEAHLSAGPQLSNGHRPNTHDFPLGRQLPTRTTPTLSPEELLNSRDCHPGLPLPPGFHPHPGPNYPPFLPDQMQSQVPSLHYQELMPPGSCLPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MGGVIRKVMDRGRGSEGEEQRVWREERGIKLNCSLQSGISVWIPLVVQLLHWLITRGKQGHFQLSPSHKEPMGMWEEASDTGMKGKKKDKNEEEEERGKKERMVNLTLEMIYLLTGEVAIRTHHVSIYFSLDEWDYIKGNKDLYREGMKEEPQQLHPLATCEYKDESNVTSHVQATLSCNNDETITIPDISPVEQPPPANWIKEEVASREEGNQSDCSINPLTEQIQETDMPTPIMGCSMSANHILDIIKEEADSYEKSILLPNSDSHAVKEEVTSCEESNQSYYSINPLTEQIQGTDTPTPIMGYSLLSSPLKIKGNEYNDDAIEGHTNFMHILDFDGHKKTQIIKKHVFCSDCGQSFGTSSELTVHRQQNHTGEKPFVCSECGKCFITPKELSVHQRTHTGEKPYSCSECEKCFSNRSCLIDHLRTHTGDKPYSCFQCGKCFSNRANRIRHQRIHTGEKPFACSECEKCFASSTELTVHRRRNHTGEKPYSCSECGKCFATTSHLRAHGRAHTGEKPYSCLECGKCFATSSNLRAHGRAHTGEKPYSCSECGKCFSTRLSLTRHERTHMGKKHFLNSIKTENNFHVTNVNVGGVIRKVMDRGRGSEGEEQRVWREERGIKLNCSLQSGISVWIPLVVQLLHWLITRGKQGHFQVSPSHKEPMGMWEEASDTGMKGKKKDKNEEEERGKKERMVNLTLEMIYLLTGEHYIPRKKSDDGGALHAPGSVIQKENNKNDKKILELMSNIIQLLTGEVAIRTDHVSIYFSLDEWDYIKGNKDLYREGIKAEPQQLHPLAACGYKDESNVTSHVQATLSCNNDGNITIPDISPVEQPPPANWIKEEAASWEWGNQSDCSINPFTEQIQGTDTPTPIMRYSMSANHILDIIKEEADSCEKSILLPNSDSHAVKEEVTSCEEGNQSDYSINPFTEQIQETDMPTPIMRYSMSANHILDVIKEEADSCEKSILSNSDSHAVNRGVTLCEESNQSYYSINPLTEQIQGTDTPTPIMGYSLVSSPLKIKGNEYNDDDDAIEGHKHFMHILDFDGHKKKQKIKKHFFCSDCGKSFGTSTEVTVHRRRNHTGEKPFACSECGKSFITPKELTVHQRTHTGEKPFSCSECGKCFITSSELTVHQRRNHTGEKPFACSECGKSFTRSKELTAHQRTHTGEKPYSCSECEKCFSNRSCLVDHLRTHTGDKPYSCFQCGKCFSSRANRIRHQRTHTGEKPFACSECEKCFASSTELTVHRRLKHTLEKPYSCSECGKCFATSSHLRVHGRAHTGEKP
The following text describes a protein:
Function:
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MNQLTSLYLAALNRVTWQQPDDIEFPAPLAQQWLLEQGSLSRRMATQCEHLTVDLLSNQIMLADTLSYDETQLLASEEYLLRQVIIYGDQQPWVFGHTLIPRSSMHNQPFDFTQQGKIPLGLTVFSADNVKRDALQVGWVETELGRLLARRSRLWMNNKPMLVTELFLATSPIYSKERV
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAATPGLHPPPPLEQDDILIVKVEEDFCWEEEPSQESEDPSPETFRQLFRLFCYQEVAGPREALSRLWELCCRWLRPELRTKEQILELLVLEQFLMVLPGEIQARVREQQPESGEEAVVLVEGLQREPRKQRQRGLEVLPDDVRPHGTGEQCLKHQEEARPGDLSLEEGSGCSSQQPPAQRGHRPKRGPQLWPKRGPAASQHQEMATASATSFVPSWSRQAPVTLEDMAAYLSQEEWQRPDPTPRDCSWDVLPEKRGLGLLPEDGEDSRKHVSMSRERDREPVRGMTRPEQPLERGGPRRVEKPYTCPECGKGFSKTSHLTKHQRTHTGERPYKCQVCGKGFSDRSNFSTHQRVHTGEKPYACAECGKRFSQSSSLVIHRRTHTGERPYACAECGKRFSNSSHFSAHRRTHAGEKPFVCSACGRGFRRGTDLHKHQRTHSGEHQPGQQSPPTARLQEAPGPRSSRHSSSCPLPRSLLEYRGQSS
The following text describes a protein:
Function:
Is probably involved in a pathway contributing to genomic integrity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MKISLVAAAMALASTASAWGKKAGPVEIPVASHLQFSAVAQIGSNSDVEASDAGFFVANTFINGEDVPINLVFENKEKDPISVVAVGGTFYDLKTDKVVVSVQGTQVGPIKVDSGKTAALTHQFETNLDAKVYRNVIQVYIQYGNEVYQVHAFDGPVSIVDPYVSPLSFKFLFAQIVLGITAAALGYYVVNVYAIPYATGTYGQEKKPVRAKPVVPAGSGVKTGPKGYDESWIPKHHLDQEKVKVKKRS
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.
Sequence:
MDSLIIVKQLETFSKSLNNNSNNNTSNENEEFIYNSFLDCVLINNNDNNDVNNQLQESLIERLKLIINSDLNISDSENHHLVKLLLLSIQRISNNSNTNSNNNENIFNIYFNILQNSHNVNNKSILDIIVNNIKQSIITFIKTNNNSINSDKIVEKLLEISNSSLISLLDNNSTNNNNNTIEYNINFKLLINIYNIINQQQNNEINKSNNSYLIILKYKEILIKNSIDLIKLLNNQDAKNLIVSQLIISLVGNSVEHLNQIKEESFKMLDQPDATEEASRIKMDGYRILSGFLQTFPSSFLYDERFWKSIISGLVDMEPLNRKRSNYLLKKSISISISNENNSEDMGKWTQYFEWNKENSSKLQKLWNTFFLINESLDDFTIHTIEPVWKELDQLVVSSSSNSSFGLHFDWLNILFKRGLQHMNPAVIKILVLDVLYAKHYIPYLPLDFVTDNMIHLISTPLIYKGSTEGSIHAAIQHFFTVYYESLKETEMKIKLFRNIITILKNNHFHRDLVINLIKFIEVITNKHKEQVPVVNNEFFPIFNTLFELSIKRLHSNGRNRLYKSVIKSLQYITDEQLSFDNMSKIIFSIPFHFHSNPQYNQLISNWLNGNSGQGANKTFNSIMEILKNHHQQQSIPNTSNIDKDFIVKLKSDSFISARIISYLKDEQFSGVIKQILDSTKQLIENNNTNSVGFFYFITLLGSILSIINLPNQIQILNQLINEIFSNTFMNYLGESFKSIPSIDYAVLLEVEESYYLIESFILGNHSNLKNKINEYFTTLLNSQQINNNNLVPTTIENEFNKIKTIQRFYGLFKDRACSANLFTIEQFENVLDRAINIELKKPKQSEGEEESVIIKNWGTINSYFIKIKWYLIRNLLTCLLHLVKSHSTESKVLNENSKKYLEIAIESLGGSNFYCSQPIIHSLTILLPLGAIDKKTNTFDQELFERALSYTWTSSVDCGILNYIGSFVQLAFQHNTLSVHVTQEQENDLGLFNHHTVLKEYFYKLLEYCNVVPGIYNLLVMKSTMIWREYPEIAIQYIDEIYEALIYGPIRVASNDLHQDENEISFYEPLVGIPSYVFNLHQDSIVESQQDEEKFGFGYVPYRDSFGRAATTIFINTMGELSQQKPSSTTDEHKINLYKKFINLITIKFLDSNFYEEFLKKKEYILNTFTHRLKIRIWQTLCVLSKFINTEDKEMSNQIGDSIVKVFFIFHLPSVRKYINIFLVNLIKSNHEIVESHLLKLFDNVNLRGDILSSITVTAAYVLINIENNDALYQKVFNRVLSLCVSGHIIVKTIASSVISQLIENDMEGLKKKLEPGVLEYLDQLNYFFKTNSQAYKLLQKQKKQMDIAKENQFTDCAFLNLFYETPVIEKLAVTEIIPPGIFDFLSSKEYLNQSILEKQLRDQLFEKSKLYPKVDDFESEDDDEDVGEETKDKKLEDVDEYIDTNPTSYQKKILPWADLEYESRSEIMTKSRQSVILVASFVDKIPNLAGLVRTSEIFNIECLVVSDMKILNDTAFQQITVTAEKWLPMEEVPEESLKQYLLGKKSQGYSLLGIEQTSSSVQLNKFDFPEKSVLVLGKEKEGIPTEFINLLDKCIEIPQLGVIRSLNVHVSGSILMWEYTKQKLNQ
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
Sequence:
MATKTDTSQDPTKLERMGKVREIGDLAVWSVSSCKPGFGVDQLRDGSLDTYWQSDGPQPHLVNIQFRKKTAVKSLCLYADYKSDESYTPNRISIRTGTHFHDLQEVEQVELSEPTGWVIIPIQDKSLQPQRTFMIQIAVLSNHQNGRDTHMRQIKIHAPVEDGPMSKFPKFSSLDCKMHSCIR
The following text describes a protein:
Function:
Likely to play a role in iron homeostasis.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Under iron-replete conditions, enriched in the nucleus. Under iron-depleted conditions, expressed in both nucleus and cytoplasm.
Sequence:
MHNTGKRYSETAKKVAAGRARKRRQAYEKDQLEKQQLEAQEAQRWEEGARTPNQKKLIMEQKKTEKLRAKKERDQLLAAEEEALGKGGRGKRY
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MVLGSPPYTVPLPKKPIQSGPLKISSVSEVMKESKQPASQPQKQKGDTSASTTAGDTLSVPAPVVQHEELIKTDHPETGEGKPKPATSEASSTSVRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALSQTARITQQAIVAQNAAVQAVTAHANILKAAMDDSEIAGDKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKEEVAGAKSHITAAEGKLHNMIIDLDNVVQKVQAAQSEAKVVSQYHELVVQAREDFKRELDSITPEVLPGWKGMSISDLADKLSADDLNALIAHAHRRIDQLNRALAEQKATEKQHIALALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKYEFEQDLSEKLAEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKVHQLWLSVEALRYRMKTASADLPTVPLGSAVEAIRASCSDSEFAQALTAALPPESLTRGVYSEETLRVRFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQQLKPPAELCPEDADTFTLLSYASYCLEHGDLELAAKFVNQLKGESRRAAQGWLKEARVTLETRQIVEILTAYASAVGIGTTQVQQQEGLGRVP
The following text describes a protein:
Function:
Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MIIVRSMEEKEISSMNVIPLVDIMLVLLTIVLTTATFIAKGEIPVELPEAKSGKAVQPQESVVITITKEGKIYLKSREVSYEELKEFLKTLNRQTPVEINADKNAKLENFVKVFDLLNQYGFKNVNLLVKKE
The following text describes a protein:
Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (By similarity). Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (By similarity).
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region.
Sequence:
MSAHEAGSSGRRRPATFHLHIYPQLPSAGSQTSCRVTATKDSTTSDVIRDVVASLHLDGSKHYVLVEVKESGGEEWVLDASDSPVHRVLLWPRRAQKEHPREDGYYFLLQERNADGSIQYLHVQLLAQPTAACRLVERGLLPRPQADFDDLCNLPELNEANLLQSLKLRFVQQKIYTYAGSILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRKHVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVERTILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYLESGIVRGAVVEKYLLEKSRLVSQEKDERNYHVFYYLLLGVSEEERQEFQLKQPQDYFYLNQHNLNIEDGEDLKHDFERLQQAMEMVGFLPATKKQIFSVLSAILYLGNVTYKKRATGRDEGLEVGPPEVLDTLSQLLKVKRETLVEVLTKRKTITVNDKLILPYSLSEAITARDSMAKSLYSALFDWIVLRINHALLNKKDMEEAVSCLSIGVLDIFGFEDFERNSFEQFCINYANEQLQYYFTQHIFKLEQEEYQGEGISWHNIDYTDNVGCIHLISKKPTGLFYLLDEESNFPHATSHTLLAKFKQQHEDNKYFLGTPVLEPAFIIQHFAGRVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRQLIGMDPVAVFRWAVLRAAIRAMAVLREAGRLRAERAEKAEAGVSSPVTRSHVEELPRGANTPSEKLYRDLHNQIIKSLKGLPWQGEDPRRLLQSLSRLQKPRTFFLKSKGIKQKQIIPKNLLDSKSLRLIISMTLHDRTTKSLLHLHKKKKPPSISAQFQTSLNKLLEALGKAEPFFIRCIRSNAEKKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDFTEQFQVLLPKDVQPCREAIAALLEKLQVDRQNYQIGKTKVFLKETERQALQERLHGEVLRRILLLQSWFRMVLERRHFVQMKHAALTIQACWRSYRVRRTLERTRAAVYLQAAWRGYLQRQAYHHQRHSIIRLQSLCRGHLQRRSFSQMMLEKQKAEQARETAGAEMSEGEPSPVAAGEQPSEHPVEDPESLGVETETWMNSKSPNGLSPKKEIPSPEMETPAQKTVPAESHEKVPSSREKRESRRQRGLEHVERQNKHIQSCREENSTLREPSRKASLETGESFPEDTKEPREDGLETWTETAAPSCPKQVPIVGDPPRSPSPLQRPASLDLDSRVSPVLPSSSLESPQDEDKGENSTKVQDKPESPSGSTQIQRYQHPDTERLATAVEIWRGKKLASAMLSQSLDLSEKPRTAGAALTPTEERRISFSTSDVSKLSPVKTSTEVDGDLSAKKPAGHKKKSEDPSAGPDAGLPTGSQGDSKSAFKRLFLHKAKDKKPSLEGVEETEGSGGQAAQEAPARKTLDVPSSQQHRHTTGEKPLKGKKNRNRKVGQITVSEKWRESVFRKITNANELKFLDEFLLNKVNDLRSQKTPIESLFIEATERFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLAAERGEKDTNLVLNVFQSLLDEFTRSYNKTDFEPVKGKAQKKKRKQERAVQEHNGHVFASYQVNIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSYCSYTGRRKSELGAEPGHFGVCVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPATVKLEDFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLDHLPEANHTSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKYKVKMEEINHLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVRTKSPRTPVVQDLEELGALPEEAAGGDEDREKEILMERIQSIKEEKEDITYRLPELDPRGSDEENLDSETSASTESLLEERAVRGAAEE
The following text describes a protein:
Function:
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MQTLFLSLLAAAVTVHAYGSGGSNWDQAYSRAKDALQKLNQTEKVGLVTGVKWMGGPCVGNTYKPESIDYPSLCLQDSPLGIRFANPVTAFPAGINAGATWDTQLLYARGAAMGAEAKGLGIHVQLGPVAGPLGKNPNGGRNWEGFSVDPYLSGVAMEKTIRGMQDSGVQACAKHWLGNEQEHYRDTISSNIGDRAAHELYVWPFMDAVKAGVASVMCSYNKVNGTWACESDALNNKLMKEELGFPGYIMSDWNAQHSTVNSAVSGLDMTMPGSDFSNPPGSIFWGSNLEAAVADGSVPQSRLDDMVTRILAAWYLVGQDQGYPPVAFSSWNGGKANVDVTADHGTVARAVARDSIVLLKNGHGTLPLRKPKSLAIVGSDAIVNPAGPNACSDRGCNNGTLAMGWGSGTAEFPYLVGPLDAIQKRAAADGTKIVPSATDDPTAGASAAAAAETAIVFINSDSGEGYITVEGNLGDRNNLDPWHNGNELVKAVAAASKNVIVVIHSVGPIILETILAQPSVKAIVWAGLPGQESGNALVDVIYGDTTPSGKLPYTIAKQAADYGASWINAETDDFPEGLYVDYRHFDAKGIAPRYEFGYGLSYTTFKYSGLWVNMDASAGAANGQVVPGGPADLFEVVGQVSVSVRNNGRVAGAEVAQLYLGLPDSAPATPPKQLRGFQKLMLQPGQTGRATFKLTRRDLSYWDVQQQKWVVPSGTFKVYVGSSSRDIREEGSFRVRRGW
The following text describes a protein:
Function:
Plays a role in primary ciliogenesis by modulating actin polymerization.
Subcellular Localization:
Cell membrane. Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MEAAAKFLNHIGPEELESCLFEETLALVAAGGRPQGHLWVTARHAPYEQEGQQVRSCLLLQAGSKGLLDGVPYSCRLTGYVSMQLETLEQEQHERLEFGAHPTERKIHMVQHPHGMTVTVTTREGEAEPQHQVFSYGWASLEGLLGEAASLLLLRVLACRRAVPPSITFPAIDKEGHLCTTTYRSLGVQQQPVGSTQVEVLVVERALHAAQGIPMVWYHSLLPSGHLARRVQVGCPVVAVLQDAPALSSTGAEPQPLFPKQLLDWEEDAQLCSWFLDRKEELRASHSTYVQQHPELFALLADFLQALLLRQPQNPILFAAEFFAPFARRQPPGPSFASSVSLSPFCSTSCPNPPPQGD
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MKSTEFLTLDSFLLHFSIFLTQENNRRNEPQQPTPSHGNFQWGGCGDDVTFGVLFSKWFTDVPWVNERASKKFLVNLHNNAVGRKLTSESLAVTCKCHGVSGSCSLKTCWYALPNAKAIGLKLQKKYFSSVEVNMKLDKRMRKRSSLPLVSVLPTRKYVDEDELIFSTISPDYCSPDVSVGSVGTEGRVCDVDSTGTKGCRSMCCGRGYTVEVQEVKYRCECKYHWCCYVKCRTCLKSIQVYRCR
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Sequence:
MFNSISRGVFASSTRFTRVARFLHQVPKLESHETWTQEGIPGFLSPKGYNLAWTDYQNYLLTNLTLLTNGTSSEYKTPYQTLLHTAKQTTQQHVFHYASMAHNNHFFFQQLDTKENASKTKPSRFLMEKLMHEDILDLDQLRNKLLTMAENTYGQGWIFLVETEDKNLKFINCHNDGTPYYYAKQQLLDLNGGIDEGNFSYLENLKSRALNNEKDYTLPILAINYWDYMYIPDYGVTGKSDYLNKLWDHINWDVVNKRLFQI
The following text describes a protein:
Function:
RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDAYREFIDPSKVNNCVGCNFISSTKKNLIVGKGSLLQIFETIQLKQSTINKPQYRLKLIDQFKLQGTITDLKSIRTIENPNLDYLMVSTKYAKFSIIKWDHHLNTIATVSLHYYEHCIQNSTFEKLAVSELILEPTYNSVSCLRFKNLLCFLPFEVIEDDEDEEEEEEEDEEDEDEGEENIDDTKEKKDKKQSKTDTIEEDKNSTTTNQEPRLFYDSSFIIDATTLDSSIDTVVDMQFLHNYREPTIAVLSSKQEVWAGNLIKSKDNIQFQVLTLDLNLKSTISVFKIDNLPYEIDRIIPLPSPLNGTLLVGCNELIHVDNGGVLKRIAVNKFTRLITASFKSFQDQSDLNLKLENCSVVPIPDDHRVLLILQTGEFYFINFELDGKSIKRIHIDNVDKKTYDKIQLNHPGEVAILDKNMLFIANSNGNSPLIQVRYRDSSKTSDTKESKLNKIEEKEDNKDDDDNDDDDEDDLYKEEEEEETQKTISKSHIEFLYHDELINNGPSSTFTLGICSKEKFKCNLPNPNYNEVSILSNAGTDSQTKLNIITPTIQPSISSSLTFSQVNRMWNLNQKYLITSDDVNYKSEIFQIEKSYARMKSKHFINNELTINMHELNNGKFILQVTPKQIVLYDNKFKKRFTLNDEIKDDEILSSILRDEFLMIFLASGDVMIFVINTYNESYDKIEIPKLLDDTIITTGYITNSYLLSAVSKNVNLLLDNNTSSNKRKRKHSALSNSEGSKKNTGKSQPSTAAPPPPPKVNKVKTFVLVTGDNRIVAFNRFHGEKCYQLNHVDKFTENLSLGFFDPNQSTVDPFIKQIMLNELGDKFDTKDEYLTILTIGGEIYMYKLYFDGENYFFKKEKDLTITGAPDNAFPYGTSIERRLVYFPNLNGFTSIFVTGVIPYLILKTVHSIPRIFQFSKIAAMSISAFSDSKIKNGLIFLDNQQNARICELPLDFNYEFNLPMKHVDIGESIKSIAYHETSDTVVLSTFKQIPYDCLDEEGKPIAGIIKDIKDTPAMSFKGSIKLVSPYNWTVIETIELEDNEVGMTLKSMILDVGSESGSTLGSDPNSLIKKYNKKKREYIVIGIGKYRMEDLAANGIFKIYEIIDIIPEPGKPETNHKFKEIFKEETRGAITSICELSGRFLVSQGQKVIVRDLQDDGTVPVAFLDTPVYVSESKSFGNLLILGDPLKGCWLVGFDAEPFRMIMLGKDTQHISVECADFIINDDEIFVLVADNNNVLHLLNYDPDDPQSINGTKLLTKASFELNSTISCLRSLPLIDIEESVQTDALTNIAVPPPLPPNTTSNYFQVIGSTQDGSFFNVFPINEAAYRRMYILQQQLIDKEFHYCGLNPRLNRIGSIKLQNNETNTKPILDYDLIRRFTKLSDDRKRNLANKVSGKGIYQDIWKDIIRFEHTLNDL