lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition. Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair. Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells. Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements.
Subcellular Localization:
Cell membrane.
Sequence:
MLLALALLLAFLPPASQKSSNLEGRTKSVTRPTGSSAVITCDLPVENAVYTHWYLHQEGKAPQRLLYYDSYNSRVVLESGISREKYHTYASTGKSLKFILENLIERDSGVYYCATWDR
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MSSPYAYLKPSLHELEEDCERNILPSKTAIDLTYAAFAMYSGNTGSANHHPPSYPGYPPAQSDVHAMPMPVIPQSHYSSTRLNNPPIDVSSDISTFLGILRGKTSDDLQTLLHNESKIISMIGESDQVRKMKSTIQTSTARNQSLADYNLKRKPDLESRINSLKQVLEKYKTLRDEYAQKVQLLGNYRIDLDTISALMKASVAQNEEEAETLADEFMDRKISVENFVNEFLEKRKEAHLRIAKSENLINIISQSGSQANWKMIMAFSIKYT
The following text describes a protein:
Function:
Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MLSASQFLKHRVSCLPMLNKVESDSTDGDPDDACQHPHDCNIFSVLVNGATDRLEGFFDESDEEDGDEVETPSTTTTAVSPSATMSAPSPTATAPTPHSGTHTPKSPLHSISHCPSFNSVAQALPHSLSPHSLCHTSSHEASRRGSAEQPSRTQSELARRIKTENILNSFHDSLEAAYEKCHGGANPEEHQSNKTEYFQQKLKGFAALDVDEQLIADYPVWLLKNVLIQGHLYITAKHMCFLSYLPRRQNANIRSGTLVKARKRSLREGTRYWCVLKNDSFSYYPDSTDVYFPAGTIDLSEALAAELCDDEGDVTEPESFRIVMPKKSVLFKADSHSAAHEWVKALQKEIFRAHNQGDTVRIVIPLQNIVDLEKTKIFEFATTIKTSVVESNETYAIDEYIFTFFKFGDDVLRTLTENGVEISGGNFSPRQSQLAVGHKHVTESVRDSTLLHASGHHHHFFHSAHHESDGKSNSKSHTSSRSHTPRNLTPQVTGEQPHERDEKRDSKLPRLPKFLRRFKDKVDDKCDDKPTLVPSFLKSRASSRRNSAEGSDRPNLASQRTSSSTLFPSAPPTPGSQPTTPGVHAPGSSTPGGSYGTTTPGTPASADSVSLAGTPGVAAPVGDIEGLNGNPMPAGIAAELKEKRKSGGATSSGAATGATTPGGAAAPGSTGNSSPGTPGGLGGPGAVGAGGPGVMGGAESAPAGTVPQQSHHAGISVVAPHDPAAAAAAADAAAPFTRGPGSGIPEIQDDSDSSDDDHWGHIGTAEVDEDPEQDTFKKKNKRFSTLSKVSDLWSGSTKHYGKHHTERLGDDDDKHLASAEEITESNERFQKRFALGTEERLIASYHCHLHRGGIPTYGKMYVSTNYVTFRSFLRTKTLMIVPLKVVENATKDSGFKFGYSGLVLTIQGYEEIFFEFASASHRDDAEVMLLRQLDIIRPHINDDIKSDDQYMLQSARLCTYEDALKAEANVEMPPVIIDGNLASVLPGLVTPQSKMLFTLLTIGSRGDVQPYISLGKALIEEGHRVRIATHSEFKDWIEGYGIEFKEVAGDPSELMKIMVDHGVFSVSFLRDAASKFRGWINELLASSWEACQGSDVLIESPSAMAGIHIAEALQIPYFRAFTMPWSRTRAYPHAFIVPDQKMGGSYNYLTYVMFDNVFWKGISGQVNRWRKKTLHLPRTNLDHMEQNKVPFLYNVSPAVLPPPVDFPDWIKITGYWFLDEGSKDYTPDDKLCRFMEKARNDGKKLVYIGFGSIVVSDPTALTKSVVESVLKADVRCILNKGWSDRLGKKDAKEPEIPLPEEVLQITNCPHDWLFPQIDACVHHGGSGTTGAGLRAGLPTIIKPFFGDQFFYANRVEDLGAGIHLRKLNVSQFSKALWEATHNERIIAKAAAVGRQIRSENGVISAIQAIYRDLDYARSLVQKKRGYTPTSDKEEETWTLVDDIERQMQDEVEKHNL
The following text describes a protein:
Function:
Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5-carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Catalyzes the decarboxylation on the malonyl group attached to PigH to yield a C2 carbanion of acetyl-S-PigH. Then, the heterocyclic pyrrole group of PigG moves to the PigJ active site Cys-525 to generate a transient pyrrolyl-S-cysteinyl PigJ intermediate (acyl donor) whose pyrrolyl group is captured by the C2 carbanion of acetyl-S-PigH to yield the pyrrolyl-beta-ketoacyl-S-PigH.
Domain:
It seems that PigJ is composed by an active ketosynthase (KS) domain and by a chain length factor (CLF) partner domain that potentially decarboxylates the malonyl group of PigH.
Sequence:
MSNDKHIAPLAVVSMGCVLPGVDHFRALDTIADWETVFQSASPLAWSETSRPIQGRQMDDSGFDFKKFSIPPLFRKAVSRETRLALRAAEDALAGLVLPESLRDCCDQFCAIHLGSDAAYRNATKVGALRALAEKLQAQGCPAAEVRRRLDDYKQPLAESLGCSSHDRVGEMASSIPARIAHFAHTRGKCQTLDGADKGGLRLLQLAQDCFRYHDSQMAVLTSVQCFHHRPQAYMLLEQGVSQDACWLEGAISLVVCPLAVAHEQGWPVLTQLGDIVTTHDGSPQPEADHPAALYFAGANQVFCQIVEMVLRQHQRCEGRSFTGGRWQVNVAQTQSLTPAVDDRVAIVDYQPITGHPLDKTQFWQTLEQGEDALREHSAAHVNAEAFVRTTQQKLSTYIHRTMSFPAHSPSDVALKKPMMPAKKQRLDVTQLYALNSCHSWSEKIRQFERVAIIIASNLSLSADRLQAMRALWSGLPGSEGAIPLPELPSINHWSWYGACGIGTAQLLAQYFGISADCYAVEAACASSLAAVHDAVRALQAGRYDAVIVGGIETATLERDLVLCSAQMMLSVSRIRPFSQGADGFTPGDGGGFVMLTHHPVPRAIATIEAISGSCDSYSMTAPDPLGQALAIKKTLSLTAIDAQTVQYLEAHGTGTELGDRSEVMSLKYSYHRDKHSPLYIGSAKYNFGHCFAGAGALSLCKVLSAFEHERIPPTPVSELNVDLPLGDIPAEVPQQAIPWRLSEDGQRKAAINAFGTGGINYHLVIRQSS
The following text describes a protein:
Function:
Uses inorganic polyphosphate (polyP) as a donor to convert AMP to ADP. Can also convert GMP to GDP, with lower efficiency. Cannot dephosphorylate ADP in the presence of polyP.
Domain:
Contains 2 fused PPK2 domains. The N-terminal domain seems to be catalytically inactive and might be responsible for the protein dimerization.
Sequence:
MFESAEVGHSIDKDTYEKAVIELREALLEAQFELKQQARFPVIILINGIEGAGKGETVKLLNEWMDPRLIEVQSFLRPSDEELERPPQWRFWRRLPPKGRTGIFFGNWYSQMLYARVEGHIKEAKLDQAIDAAERFERMLCDEGALLFKFWFHLSKKQLKERLKALEKDPQHSWKLSPLDWKQSEVYDRFVHYGERVLRRTSRDYAPWYVVEGADERYRALTVGRILLEGLQAALATKERAKRQPHAAPLVSSLDNRGLLDSLDLGQYLDKDAYKEQLAAEQARLAGLIRDKRFRQHSLVAVFEGNDAAGKGGAIRRVTDALDPRQYHIVPIAAPTEEERAQPYLWRFWRHIPARRQFTIFDRSWYGRVLVERIEGFCAPADWLRAYGEINDFEEQLSEYGIIVVKFWLAIDKQTQMERFKEREKTPYKRYKITEEDWRNRDKWDQYVDAVGDMVDRTSTEIAPWTLVEANDKRFARVKVLRTINDAIEAAYKKDK
The following text describes a protein:
Function:
Cofactor for the uncoating of clathrin-coated vesicles (CCVs) by Hsp70-type chaperones (SSA1/2/3 and SSB1/2). Coat disassembly is important for fusion of vesicles with target membranes and for recycling components of clathrin coats to the cytoplasm for further rounds of vesicle formation. Binds to assembled clathrin and recruits the ATP-activated chaperone to CCVs. Stimulates the ATPase activity of the clathrin-associated Hsp70-type chaperone SSA1, which then disrupts clathrin-clathrin interactions, leading to release of the clathrin coat. In addition, prevents unproductive clathrin assembly in the cell. Also required for cortical endoplasmic reticulum inheritance.
Miscellaneous:
MISCELLANEOUS: Present with 768 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein.
Domain:
The TPR repeats and the J domain are required for interaction with Hsp70-type chaperones. The J domain is responsible for stimulating the ATPase activity of the chaperone.
Sequence:
MSDPFAHLLTSLKNKDSASASKETTPQSSNSPSITGSAVADVARTDKSPNDSLHSISAPPLIPSPKVDFSAPPLVPTNSTTKSNTANNTPPSALANTDDDFNQLFGMGTVTTTDTIQKPDEDYYGSKEDHLYNGDDALVDEVKDMEIARLMSLGLSIEEATEFYENDVTYERYLEILKSKQKERNDLAIRKKESGIKMEKSGLSNIVGTDSNNLFSMATDFFNKGKKLVDQWTSFPPEANDRLNNYSKTHDKVEDYDLPQVNDSPNRILFEDNEVVENLPPADNPDQDLLTDFETKIDITKRTAPDVSHSSSPTSGILIEENSRRNEPLIEDSLLDFSEGNLTNSKSNEDSTLFNENSNTDSTIPISDIELSGYNEFKAKGTSLFKNGDYINSLQEYEKSLNTLPLNHPLRIIALSNIIASQLKIGEYSKSIENSSMALELFPSSKAKWKNKISNSDPERSFNDIWPKIMIRRAESFEHLESFKKALETYQELIKKNFFDDKIMQGKRRCQDFINPPPVKKSMPVKKKTTTTSPATKKQNLTASSSNSPISVDSTSEIKKRELENAKLALYDKVFEKISSWKDGKDDDIRHLLANLSSLLTWCNWKDVSMQDLVMPKRVKITYMKAVAKTHPDKIPESLSLENKMIAENIFSTLSIAWDKFKLQNDIN
The following text describes a protein:
Function:
Involved in the regulation of root growth. Involved in the suppression of the root bending in response to touch stimuli, gravity and light. Negatively regulates stimulus-induced root bending through inhibition of root tip rotation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MVTYVSALFYGFGGIVVAGVALLVAFQEKLVYVPVLPGLSKSYPITPARLNLIYEDIWLQSSDGVRLHAWFIKMFPECRGPTILFFQENAGNIAHRLEMVRIMIQKLKCNVFMLSYRGYGASEGYPSQQGIIKDAQAALDHLSGRTDIDTSRIVVFGRSLGGAVGAVLTKNNPDKVSALILENTFTSILDMAGVLLPFLKWFIGGSGTKSLKLLNFVVRSPWKTIDAIAEIKQPVLFLSGLQDEMVPPFHMKMLYAKAAARNPQCTFVEFPSGMHMDTWLSGGEVYWKTNLQFLEKYAPEKRKEDTGR
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Miscellaneous:
MISCELLANEOUS: Present with 9620 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVKSYQRFEQAAAFGVIASNANCVWIPASSGNSNGSGPGQLITSALEDVNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHKDSITGFWCQGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLAVKDDLLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDKTSFFYIQNADKTIETFRIRKEEEIARGLKKREKRLKEKGLTEEEIAKSIKESYSSFILHPFQTIRSLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDISDDNKLLATASNGSLKIWNIKTHKCIRTFECGYALTCKFLPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQVFLEEEKEKELEEQYEDTLLTSLEEGNGDDAFKADASGEGVEDEASGVHKQTLESLKAGERLMEALDLGIAEIEGLEAYNRDMKLWQRKKLGEAPIKPQGNAVLIAVNKTPEQYIMDTLLRIRMSQLEDALMVMPFSYVLKFLKFIDTVMQNKTLLHSHLPLICKNLFFIIKFNHKELVSQKNEELKLQINRVKTELRSALKSTEDDLGFNVQGLKFVKQQWNLRHNYEFVDEYDQQEKESNSARKRVFGTVI
The following text describes a protein:
Function:
Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MKTARPGKLKRQEEQASFISWRFALLCGCILLALVGLIMRTAYLQVINPDKLVREGDMRSLRVQEVPTARGMISDRSGRPLAVSVPVNAVWADPKELIEQGGISLDTRWKALSDALEIPLDQLATRINANPKGRFVYLARQVNPAIGDYIRKLKLPGIHLRQESRRYYPAGQVMAHIIGVTNIDGQGIEGVEKSFDRWLTGQPGERTVRKDHYGRVIEDISSVDSQAAHNLVLSVDERLQALVYRELNNAVAFNKAESGTAVLVDVNTGEVLAMANSPSYNPNNLTGTPKDAMRNRAITDIFEPGSTVKPMVVMTALQHGVVKENSVLNTLPYFVNGHQIKDVARYAELSVTGILQKSSNVGVSKLALAMPSSALVDTYSRFGFGKATNLGLVGESSGLYPKKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSMGVYRPLSITRVDPPVAGERIFPEPLVRTVVHMMESVALPGGGGTKAAIKGYRIAIKTGTAKKVGPDGKYMDRYLAYTAGVAPASNPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRTMNIEPDALPTGDKSELVINTKEGSGGRS
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice site.
Subcellular Localization:
Nucleus.
Sequence:
MDDLHGRNGRMHIGVAQNPMHVQYEDHGLHHIDNENSMMDDHADGGMDEGVETDIPSHPGNSADNRGEVVDRGIENGDQLTLSFQGQVYVFDRVSPEKVQAVLLLLGGREVPHTLPTTLGSPHQNNRVLGLSGTPQRLSVPQRLASLLRFREKRKGRNFDKTIRYTVRKEVALRMQRKKGQFTSAKSSNDDSGSTGSDWGSNQSWAVEGTETQKPEVLCRHCGTSEKSTPMMRRGPDGPRTLCNACGLMWANKGTLRDLSKVPPPQTPQHLSLNKNEDANLEADQMMEVTGDISNTQ
The following text describes a protein:
Function:
Catalyses the transfer of galactose onto proteins or lipids.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MKYFPGHYDNRSTTRHGRSPSYSNYLRNFRFRYGTEAGSVKKVAKYVVALLACIQLPLLLYFHRGGDRGRLEYSPEQPESDVLTRMMSRDVGRLEGATYDRTPPIRMMQPMQNVGLLRKLTNQVYSPTNYSGTESFVTSIDAPTQVKSTMPRCPMTPPNLFGRLEFKFNTTPPSFEHTTLHNQNLHPGGSYFPEGCVPRHRVAIIIPHRSREVHLKALMWHLHPILQRQQIYYKVYVIQQAYNLAFNKAKLMNIGYLEAMKEDLYDCVVFHDVDLLPEDDRLLYHCTDTPKHLSVAIDKYGYRLPYPSLFGGVTMLSKDQFRDVNGYSNMFWGWGGEDDDMFARIFSRGYTIKRPPFHQAKYRMSYHERDKGNKL
The following text describes a protein:
Function:
Required for normal axon patterning during neurogenesis.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MTSNSCLISLGLLLVLIQILAPAKAAEHSVFTHKNASSVLGQLVTSSTLVWESYDPKDATQLQFAVEGGKYVTEDEHYPMYVCRVPIDGIQVSGHTEKILQRHVCLAAHYKHGKYDNFDVLMNKGHLGKVGWRHWRKFDAGVPVGAIRIGDDSYIGRHRAPSQPNKDGVVTHWGADFNLGHLEPVGLGKIRVIEAEREKYYDDGEVLVETEPFRYELRDIKLDRLRTDIQENMTELVTRKLENLEDKYSTVETILSYTFNYNQYWGSHEGVARGLPTKIFEKDEAVPAEINWALKHTEKRSENKAVHTKLWPGTAINVTLRGNYVTLEAPYSGKLFAFYYGSDESVSRKISAEVRKSYLKEVKLEFSPVYWIENGTLVPTTTTTTTTSTSTTTHATTTSTNEPTPINEPPLVHMKDNGVQHSGPDTLEKTLHDSPSSNELNSHEAPENMSSDPGKDVALAGFGVNAAGSTFIAGSALLTLLLTIFLSL
The following text describes a protein:
Function:
Probable ATP-binding RNA helicase.
Sequence:
MQRKEANPFQILGLRPWLVKQLTKLGLKGATPIQQKCIPAILAGQDCIGAAKTGSGKTFAFALPILERLSEEPVSHFALVLTPTHELAYQISEQFLVAGQAMGVRVCVVSGGTDQMVESQKLMQRPHIVVAMPGRLADHLTGCDTFSFDNLKYLVVDEADRMLNGDFDESLSIIERCLPKTRQNLFFSATMKDFIKESSIFPIASDCFEWSQDSDVATVETLDQRYLLCADYDRDMVLIEALRKYREENENANVMIFTNTKKYCQLLSMTLKNMEIDNVCLHGFMRQKERVAALSRFKSNQIRTLIATDVAARGLDIPSVELVMNHMLPRTPKEYIHRVGRTARAGRKGMSISIFRFPRDLELLAAIEEEINTKLTEHPIDQRMVERIFMQVNVTRRESEMQLDNNDFDERAQNYRRKTWIMEGKDPDQMEALYRKKQKDKLREIRRKRKLQHAEPAASEEGKALLQDERFKSVDSARFEKKGKGRSRATQEDTPTKPLKRLNKEKPVAQKGRADVKKDKA
The following text describes a protein:
Function:
Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation.
Miscellaneous:
MISCELLANEOUS: Expressed from one of two small open reading frames (smORFs) encoded by a bicistronic transcript. The ORF for sloth1 has a non-canonical Kozak sequence while the ORF for sloth2 has a classical optimal Kozak sequence. Both ORFs are expressed because ribosomes occasionally fail to initiate translation of sloth1 and continue scanning to initiate translation of sloth2, a process known as 'leaky scanning'; MISCELLANEOUS: The 'sloth' peptides were named for the slow movement phenotype of mutant flies.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion.
Sequence:
MPAGVSWGQYLKFLGCALASMMAGSQAVHLYYKPLEDLRVYIEQEQHSTQVDPTAKPPESA
The following text describes a protein:
Function:
Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
Subcellular Localization:
Secreted.
Sequence:
MKAAMFALVLICLGSVWPSAGSQPLDSSIIHSSPNDIQKLSRRYAESTIASDISKIVDSMVQKNFVNFLLNQREKKSEPALTEDPESHIFNDLLKKEFVMWIQSKGDTFKNQ
The following text describes a protein:
Function:
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular Localization:
Nucleus.
Domain:
The N-terminal half of the protein contains two conserved domains I and II. Domain I includes a slightly degenerated ERF-associated amphiphilic repression (EAR) motif which seems to be involved in the activity of transcriptional repression. Domain II is required for the correct degradation of the protein through the SCF-mediated ubiquitin-proteasome pathway. Interactions between Aux/IAA proteins and auxin response factors (ARFs) occur through their C-terminal dimerization domains III and IV.
Sequence:
MAKEGLALEITELRLGLPGDNYSEISVCGSSKKKKRVLSDMMTSSALDTENENSVVSSVEDESLPVVKSQAVGWPPVCSYRRKKNNEEASKAIGYVKVSMDGVPYMRKIDLGSSNSYINLVTVLENLFGCLGIGVAKEGKKCEYIIIYEDKDRDWMLVGDVPWQMFKESCKRLRIVKRSDATGFGLQQD
The following text describes a protein:
Function:
Glucosyltransferase involved in the biosynthesis of the core oligosaccharide region of lipopolysaccharide (LPS). Catalyzes the addition of a glucose (glucose III) to the outer-core glucose II.
Subcellular Localization:
Cell inner membrane. Note=Membrane associated.
Sequence:
MDSFPAIEIDKVKAWDFRLANINTSECLNVAYGVDANYLDGVGVSITSIVLNNRHINLDFYIIADVYNDGFFQKIAKLAEQNQLRITLYRINTDKLQCLPCTQVWSRAMYFRLFAFQLLGLTLDRLLYLDADVVCKGDISQLLHLGLNGAVAAVVKDVEPMQEKAVSRLSDPELLGQYFNSGVVYLDLKKWADAKLTEKALSILMSKDNVYKYPDQDVMNVLLKGMTLFLPREYNTIYTIKSELKDKTHQNYKKLITESTLLIHYTGATKPWHKWAIYPSVKYYKIALENSPWKDDSPRDAKSIIEFKKRYKHLLVQHHYISGIIAGVCYLCRKYYRK
The following text describes a protein:
Function:
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Sequence:
MYTLKEGIDFYIEPMQNKKVTVFDTTLRDGEQTPGVSLTSSQKLEISRQLDKLGVDIIEAGFPISSEGDKESVKSISNAGLETTVCGLARVLKKDIDACFESDVGLVHTFVPTSDVQRIYTIKKSQEEVIQLAVEAVQYIKDHGLKCMFSAMDATRTDPAYLIEVFKAVQEAGCDIINVPDTVGVMVPSAMYRQIKDIAAEITIPIDVHCHNDFGLAVANSLMAVEAGASQVQVTINGIGERAGNADLAQTVMSLASIYGIKTNIRTEYLVETSKMIENYTGIRLPPNTPVVGQNAFSHESGIHSQGVLEKSDTFEPGIMTPEMVGHRRRIVLGKHTGKHAVKQSLESAGVKTSENQLDEIVLRIKEIANKGKQITDADLYAVASAVLGKASSEEELIKLKEVSVMTGNILTPTAVVKADIEGKEIIAAKTGVGPVDAALKAVRDILGESNHFRLQEFRIDAITGGADALADVYIGLENEKGRIVTARSANPDIVMASVEALINAMNLLYKKEKS
The following text describes a protein:
Function:
Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway; The FZ domain is involved in binding with Wnt ligands.
Sequence:
MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGSETVV
The following text describes a protein:
Function:
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MHDLQSRISAIASFFLTVLATQFSLVALLQLVLVFSKSAIVVNSFEPARVKLVSGRVGGGDYYMYGSPYTNLGVISFDLDADLSSYFQWNTKLLFVSAIVEFTNSQYHVNQAVIWDDLISDKEDAVIVLKNQRHEYQVHDLTNSLANSKANLTLQLQVVPWVGVMRTYRHVVADGITFPDAPAKKG
The following text describes a protein:
Function:
DIG2 and DIG1 are negative regulators of the filamentation and pheromone induced mating program. DIG1 and DIG2 inhibit the transcriptional activity of STE12 by direct protein-protein interaction. DIG2 binds to the DNA binding domain (DBD) of STE12 and thus inhibits transcription when overexpressed.
Miscellaneous:
MISCELLANEOUS: Present with 1310 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MNKEEQEDPQQEQISTVQENDPRNLQQLGMLLVSPGLDEDRLSEKMISKIKKSRDIEKNQKLLISRLSQKEEDHSGKPPTITTSPAEKTVPFKSLNHSLKRKRVPPALNFSDIQASSHLHGSKSAPPNITRFPQHKNSLRVRYMGRMAPTNQDYHPSVANSYMTATYPYPYTGLPPVPCYPYSSTPTQTHAYEGYYSPMYPGPLYNNGIIPADYHAKRKKLAGRSPHLEDLTSRKRTFVSKHHNGDPIISKTDEDIECSVTKNSLSEGASLNDDADDDNDKERIIIGEISLYDDVFKFEVRDDKNDYMKACETIWTEWHNLKK
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MNVVQGLLSAVKPLPDGDSADRLSYCLTTVGLILGSAFVSGWSFVGSPIQCWFPAYYKGWWMEYALDYCYVQNTYFIPFADQKISNAFDFGAHMVEIPKNITDREKKEISYYQWVPFMLAFQAFLFYAPIMFWRAIYESAGYKVKAICETCAVSHNMEPVDRKKNMAIVSRFLTQEHDISSALGGRFRNMGGGGTSIIFAYLVTKLLFCINAIFQFFLLQKFLNVESPLWGFTVFTDLLAGREWTETANFPRVTLCDFSVRVLGNLHRHTVQCVLMINMFNEKIFVGLWFWLCIMVAISVSSFIYWLATSSTSSYGRSVVSHYIHKMDPSMEKSPRKKALLDEFITTKLHSDGVFLIRLISSNSGDTITASLLKELWENFMEDRVNLPPPYTEPLLLGKKTIDEDEL
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MNDSELTSYEFERRFDQQRAFEWMQENWRKSFMLCGLYAALVFGGQHFMRERPKLNLRRPLVLWSLSLAIFSIIGAVRTGTYMLHVLLNGGFRQSVCDSSFYKAPVTKFWAYAFALSKVPELGDTMFIILRKQRLIFLHWYHHITVLLYSWYTYKDQVAGGGWFMTMNYMVHSLMYSYYAARAAGLRVPRVCAMTITAAQILQMAMGLVVLAYVYYWMDIAHCFSYVDKVVWGTIMYLSYLLLFASFFYNTYLKDSSEVKGTKAE
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MTDLEAECLSLGLPPECGSPPSPLDSSLQVDCGTGPAGSAPAPTLALLSSDCPTPTLSSLAAEIVEPLVMLPCVKSEPEDGDLEPIRTVDLSEIQPLSTAELGHEQIKMEISGLDYIKSEHHGGHHLGPFHHGDVPELDYKSHYEAGSVFDYISQVTDTLEYIKSDPHVDLHCYYSAELSSLKSEYLDCVATPPHLQHNGLESIHMAELRSELNKLRPDGPLIDGIGKLDPDFAGAALYELQPHGEAGKSPAAAGAAGATGTVIKTKTHSPTVRKPRNMQGEKPFSCTQCGKNFSTLGNLKTHQRIHTGERPYTCSQCGKSFGQAGNLKRHQLIHTGQKPYVCAHCPKGFTKADDLRSHQRLHTGERPFICSTCGKSFSQSKELKAHQLSHTGERPFCCAHCGKSFTKETSYHNHVQIHTGEKPFTCSQCGKTFSNSGVLKTHEKIHTGERPFGCTQCGKSFGRLGHLKAHQQIHTGERPYACPHCGKTFSQSGHLKAHEQIHKRERADAASDGGGSSSSSVVGGDSS