lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the sporoblast-to-spore polar tube biogenesis. Plays a role in the control of the polar tube extrusion as part of a specific response to ionic stimuli.
Subcellular Localization:
Spore polar tube.
Sequence:
MLLFLLCLYSMVARGDLGSRSSSHAVHHHHSKEGKNASGMDYGNRSTRNARVKVRLHNHNDDSQDGHHHHKVHRSHGGSIKPHNQKHAKLIRNMIGTHENDPENLTHEEKDLANMAAHGNLDALDMLYRNGSITPDVAESVGGSIPGGITEPVVIQPAESSPMEVNEEARVVDTMSPPDYSDPTGVYVSNGVATGRTNEEQAEINVLNRNENPIDDGIAEEAYSSLLSVGHSLPVAKAVADEIKDANVRKMLRTKRAYDISQPPVNPVYIPQAELARATNSKDVVSDTDRQMFMKKVFEEYIRQGAPVERANFEAGQAGFLIDEYNENLASGLSPDAAYEKAMSLVDLNYQHATRAAAIAGGGQVAAQNAADRSLIEETSANEMVKTPSGLRPEVLKKKEEAINSKKLDRAQDLSSYLTKLHIVEPVNRAHQKLSQAAALKDAASMEGLDNPVVQEKILTDVAASSAEDLAKAHENLENVKTQLKPGGRKTNALNFLSKVLTEKAIKDVNQRNEEMQKEAVKAQKEANENSAVKSAEEHLAKAAEQQIINNEGKSVFSKVLESTGDISEAAKAREEAERAMAETLRHQREARKAEVMKMLGPMGMNSSVKEAVEHMATAHAGLNVVGSDLNELNKKYEEEVAHQSNIEELLRETATSNLEVKEVIPPTTSRVGISEGKIKLPLKGFSNEEPKTEEETIVQSRQRNRRNQVRNKVIGTPVESGLNVVEMEDGYMHISEAAKALKINKGKVFYPESAKGIMEKQKLDTSLLEHKFNTGERAGLDKGVGYYEADASGFTLPLPSPLNPVPTSTMTNEEKSLNIGHAFELEIEDGELIQTPWIEFVKDMRPMVNGRMAHEAEVAAASEMKSRVEEEKKAKNLEGITTEVYTNPDGSKFVEVSSPYGVPEIMTMDQAVESLKSVGSSSVGAVSEEAKKQTPEVPLDMAVTNSVKGSEESFVSSVLSTIQKIGNGKALAKRNAFNGKVDGEKAAIVDEYNKELINEHLSPSSTVEARVRNSIISKAESYARSMGISTQSFLNMISQLPDSSIKEMISYNEAPPSARKDVAETHFYNQIASILPDSKTANTGSVTEMIFNNISTVTHEPNTVGGEILEQMTVPNLKTIEQVETKKTPTGTTQVSVSVPNDPGKIQVLGEVKFKGNPTTTPSSGRRPASNQAVAPANVVPGPMVPSSGRNPLKPGARLPANNGPVSNAPAARIPAGQPDHTMRGFSHSFPNNPQAPGIGATPSPAVGYSGKIAR
The following text describes a protein:
Function:
Cytosolic inhibitor of vacuolar proteinase B (yscB), probably regulating protease B activity during limited proteolysis. PBI2 is a component of the LMA1 complex, which is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi.
Sequence:
MNQNKKLTGLILLAIISIITLFNFKTISQITAIRSFVSPASSTATNTNTKSTMSDSKGYIITLKDTCADSEASSIKSKITELGGKITNEFSLIKGFSAQLPTIHAEALPKDFAGIANIEEDGEVRTQ
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MMYTKMSSQWLLWTFAAFLLALTVDAQLSTTFYSSSCRNLTARVDEIIRGHIRRDRTLAPSLLRLHFHDCFVRGCDASVLLNSPRGAQGEKDAIGNKDSLRGFEIIDDVKTKIETMCPGVVSCADLLALSARDSMRAFGNITWSVPLGRRDGTVTSASEANNDLPPPFGTFSSLSAIFRRKGLTVKDMVILSGAHTVGTARCASMQTRLYSFSSANPTDPTLDPTFASRLKRQCPQGDNTTLIRNDQTKPTDTWDFNYYSNVLRSKGLFGSDDAMKRNPAARKIVLSQNKPGSPFSAEFAKAMEKMGRIGVLTSRQGQIRRTCTRTN
The following text describes a protein:
Function:
Probably acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP (By similarity). May also chaperone the processing and/or trafficking of small GTPases independently of GEF activity (By similarity). May be involved in the control of polarized cell growth via CDC42-mediated signaling (By similarity). May also be involved in the control of cell-wall organization via RHO1-mediated signaling (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTASDTVYLFQSLADRSKNPQERSLFRNYISEALELLRETPSSPTVVHEQCFRFLANSCSDNNENRAAFFNLGGIDVLKPYCSKDNEYSALAFAVIHNCILDSREYRAQVADAQILNLAITYWIDWQHKLKAPFFNMLSFVCEMLYPFCKDCSLVFMGLQLLPSMVREGIDPFTIFAKAFDNSLVCVSFAQNPSMLIDSIDLVRNMPDFTKKTDMLNLFPRIAEHDAVLSTSLHADPQFLDFLESCFRSDDSNSITMASLFIGNLVRRDDIAKQLMQKDFLNMLISCIMQEKDVDGNVERVYACCAALRHFMIPVSSRAHFAPTAILLQEKLASSRFTQLHYISASMIRLSMPYILCELADHPERFYKLKDWSKSPDFNLALESNRTLLGFVKHYLTVPKSKEKISAFFKNNINLFEESVVTVLSTESKYPIVIGEAVFVAILMIKHGYANVAQTIIASPVYEALKSYRDDPNLAYQLKQNVRSLLVLVEHR
The following text describes a protein:
Function:
Acetylates and succinylates nucleoid-associated, DNA-binding protein HupB.
Sequence:
MSRHWPLFDLRITTPRLQLQLPTEELCDQLIDTILEGVHDPDRMPFSVPWTRASREDLPFNTLSHLWQQLAGFKRDDWSLPLAVLVDGRAVGVQALSSKDFPITRQVDSGSWLGLRYQGHGYGTEMRAAVLYFAFAELEAQVATSRSFVDNPASIAVSRRNGYRDNGLDRVAREGAMAEALLFRLTRDDWQRHRTVEVRVDGFDRCRPLFGPLEPPRY
The following text describes a protein:
Function:
Ketoreductase; part of the gene cluster that mediates the biosynthesis of novofumigatonin, a heavily oxygenated meroterpenoid containing a unique orthoester moiety. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase nvfA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations. DMOA is then converted to farnesyl-DMOA by the farnesyltransferase nvfB. Epoxydation by FAD-dependent monooxygenase nvfK, followed by a protonation-initiated cyclization catalyzed by the terpene cyclase nvfL leads to the production of asnavolin H. The short chain dehydrogenase nvfC then as a 3-OH dehydrogenase of asnovolin H to yield chemesin D. There are two branches to synthesize asnovolin A from chemesin D. In one branch, chemesin D undergoes Baeyer-Villiger oxidation by nvfH, methylation by nvfJ, and enoyl reduction by the nvfM D enoylreductase that reduces the double bond between C-5'and C-6', to form respectively asnovolin I, asnovolin K, and asnovolin A. In the other branch, the methylation precedes the Baeyer-Villiger oxidation and the enoyl reduction to yield asnovolin A via the asnovolin J intermediate. Asnovolin A is further converted to fumigatonoid A by the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfI that catalyzes an endoperoxidation reaction. The alpha/beta hydrolase nvfD then acts as an epimerase that converts fumigatonoid A to its C-5' epimer, which then undergoes spontaneous or nvfD-catalyzed lactonization. The following step utilizes the ketoreductase nvfG to produce fumigatonoid B. The dioxygenase nvfE further converts fumigatonoid B into fumigatonoid C. Finally the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfF catalyzes two rounds of oxidation to transform fumigatonoid C into the end product, novofumigatonin A.
Sequence:
MTQGKHCVPQGSTILVTGANGYLASAITKLLLELGYKVRGTVRAPKPWLNHYFEERYGSGNFETVIITDFQDTDTWDQALEGISGIAHVAHDMAWSSDPNIAVRGPVKAILNILDIASKHDSVKRIVLTSTIGAAPCIDINGNPATTPVNDDDWNDFAVEAAWSDSTPEEQRVYINHCAAKVEGDRKALQWVQDNQPGFDVNIVMPGFSVGRILHASITGQSMREIVGLLQGKPTKMFEFVPPWFINTEDVARLHVIALLKPEVSSQRIFACASPFTWKEVVSILRELDPSNTLIPDAPDENRRPCHVIPATEAERLIQDFFGRNGFTSLRDSLASAVTKSA
The following text describes a protein:
Function:
Catalyzes the formation of isopentenyl diphosphate (IPP), the universal five-carbon isoprenoid building block of all natural isoprenoids. Acts in parallel with the mevalonate (MVA) pathway and plays an important role in regulating the formation of both MVA and methylerythritol phosphate (MEP) pathway-derived terpenoid compounds by controlling the ratio of isopentenyl phosphate (IP) and dimethylallyl phosphate (DMAP) to isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Controls the levels of IP and DMAP that are competitive inhibitors of the farnesyl diphosphate synthase. Regulates the production of farnesyl diphosphate-derived terpenoids in the cytosol, and geranyl diphosphate-derived compounds in plastids.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MELNISESRSRSIRCIVKLGGAAITCKNELEKIHDENLEVVACQLRQAMLEGSAPSKVIGMDWSKRPGSSEISCDVDDIGDQKSSEFSKFVVVHGAGSFGHFQASRSGVHKGGLEKPIVKAGFVATRISVTNLNLEIVRALAREGIPTIGMSPFSCGWSTSKRDVASADLATVAKTIDSGFVPVLHGDAVLDNILGCTILSGDVIIRHLADHLKPEYVVFLTDVLGVYDRPPSPSEPDAVLLKEIAVGEDGSWKVVNPLLEHTDKKVDYSVAAHDTTGGMETKISEAAMIAKLGVDVYIVKAATTHSQRALNGDLRDSVPEDWLGTIIRFSK
The following text describes a protein:
Function:
Involved in the replication of mitochondrial DNA.
Subcellular Localization:
Mitochondrion.
Sequence:
MLLSLRAGRASRPSASFIRLAKYRAQKPQHILIPFRPWRTYSTEADAAREESASTIGQLKDDPELRLNEIGVQQISGYVYSQIFATEQSPPSQELIDLSMDHLRRHELFGKNTDHAPPICFDLPELHGDTLDEHFYKLGIDASEPYLTYAKDFAKVETPPRPLEWSHQSGWTKYGGDGSMESVEAPNEDMLCFDTEVMWKESSFAVMACANNFLDTMSLHVAVNGMCSRQRPTWMKHRKDRELREKIAAETDNAELASLLGQRSLMEEEEAELWIGRSSVNSLRDVAKFHLNVTIDKAERDAFGECGREEIMAKLDSLLDYCAADVDITHRVYKRVFPNFIETCPHPVSFAALRHLSSVILPVNRSWESYVANAEATYLKLSDAVQERLLALKEKALEIKDDKPTWSKDPWLRQLDWSGQEIKYLKKRTKDGDLKPAKQKMAGKPKWYKDLYPTAAGPINLSVRTRIAPLLLRLAWDGYPLVWSDKYGWTFRVPIEEAHKYTEKQMQECNAFEAPDMALRDDTSAAYFKIPHKDGPLARCGNPMAKSYMQYFEKGILSSEFSYAKEALQMNASCSYWISARRRIQSQMAVYETDGAKGPATSESQSESHSESQLESQSENQLESQMAVYETDEAKGSATSESQLVSQLESQSESQSESQSKPQLKSPSETGYILPQVIPMGTVTRRAVENTWLTASNAKKNRVGSELKSMIKAPPGYCFVGADVDSEELWIASLVGDAQFKLHGGNAVGFMTLEGTKAAGTDLHSRTASILGITRNDAKVFNYGRIYGAGLKFASTLLRQFNPSLSESETSETAANLYKATKGVKTNRKALHPGPFWRGGTESFVFNKLEEFAEQEKPRTPVLGAGITQALMARYVSKGGFMTSRINWAIQSSGVDYLHLLIVSMDYLIRRYNINARLAITVHDEIRYLVKDDDKYRAALALQVSNLWTRAMFSQQMGINDLPQSCAYFSAVDIDHVLRKEVDMDCITPSHDTAIPPGESIDIQNLLLQPTARLDPTIVPTDPPNPSIIPYESRIPVMESLQKSTDLMFLKAQITSSDQELKDILKEKKKLDGKNAPGERKTRKNDVVPYHTYAHLMEEPIMVSDALRVGEERKGGNVQEIGNHDKNIRVSIVIYIYCSSPIDEQT
The following text describes a protein:
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MADNADDLFQIPKNFYKEGSHFIKRCVKPDRKEFLSISKAVATGFVLMGLIGYIIKLIHIPINKVLVGGA
The following text describes a protein:
Function:
Aldehyde oxidase able to catalyze the oxidation of retinaldehyde into retinoate. Acts as a negative modulator of the epidermal trophism. May be able to oxidize a wide variety of aldehydes into their corresponding carboxylates and to hydroxylate azaheterocycles (By similarity).
Miscellaneous:
MISCELLANEOUS: AOX genes evolved from a xanthine oxidoreductase ancestral precursor via a series of gene duplication and suppression/deletion events. Different animal species contain a different complement of AOX genes encoding an equivalent number of AOX isoenzymes. In mammals, the two extremes are represented by certain rodents such as mice and rats, which are endowed with 4 AOX genes, and by humans, whose genome is characterized by a single active gene.
Subcellular Localization:
Cytoplasm.
Sequence:
MPSSSDELIFFVNGKKVIEKNPVPEMNLLFYVRKVLHLTGTKYSCGGGGCGACTVMISRYNPESKKIYHYPATACLVPVCSLHGAAVTTVEGVGSIKRRIHPVQERLAKCHGTQCGFCSPGMVMSIYTLLRNHPEPTPDQITEALGGNLCRCTGYRPIVESGKTFSPESSVCQMKGSGKCCMDLDEGCSESTKERMCTKLYNEDEFQPLDPSQEPIFPPELIRMAEDPHKRRLTFQGERTIWIMPVTLNGLLELKASYPEAPLVMGNTAVGPGMKFNNEFHPVFISPLGLPELNLVDTANSGGVTIGARHSLAQMKDILHSLTLEQPKEKTKTHQALLKHLRTLAGPQIRNMATLGGHVVSRPDFSDLNPILAAGNATINVISKEGQRQIPLNGPFLERLPEASLKPEEVALSVFIPYSGQWQYVSGLRLAQRQENAFAIVNAGMSVEFEEGTNTIKDLQMLFGSVAPTVVSASQTCKQLIGRQWDDQMLSDACQLVLEEIRIPPDAEGGMVEYRRTLIISLLFKFYLKVRRWLSEMDPQKFPDIPEKFVSALDDLPIETPQGIQMFQCVDPNQPEQDPVGHPIMHQSGIKHATGEAKFVDDMPRINQELCLTVVTSTRAHAKITSIDVSEALAYPGVVDVITAEDVPGDNNHSGEIFYAQNEVICVGQIICTVAADTYIHAKEAAKRVKITYDDIEPAIITIEQALEHNSFLSSEKKIEQGNVDYAFKHVDHIIEGEIHVEGQEHFYMETQTILAIPQTEDKEMVLHVGTQFPTHVQEYVSAALKVPRNRIACQMKRTGGAFGGKVTKPALLGAVCAVAAHKTGRPIRFILDRSNDMLITAGRHPLLGKYKIGFMNNGKIKAADVEYYTNGGCTPDESEMVIEFIVLKSENAYHIPNFRCRGRACKTNLPSNTAFRGFGFPQATVVVEAYIAAVASKCNLLPEEIREINMYKQISKTAYKQTFNPEPLRRCWKECLQKSSFFARKQAAEEFNKNNYWKKKGLAVVPMKFSVAVPMAFYNQAAALVHIFLDGSVLLTHGGCELGQGLHTKMIQVASRELNIPKSYVHLVETSTVTVPNAVFTAGSMGADINGKAVQNACQTLLDRLQPIIKKNPKGKWEEWVKKAFEESISLSATGYFKGYQTNMDWEKEEGDPYPYYVYGAACSEVEVDCLTGAHKLLRTDIFMDAAFSINPALDIGQVEGAFIQGMGFYTIEELKYSPKGVLYSRGPDDYKIPTVTEIPEEFYVTMVRSRNPIAIYSSKGLGEAGMFLGSSVLFAIYDAVTTARKERGLSDIFPLNSPATPEVIRMACKDQFTDMIPRDDPSTFTPWSIHVS
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MEQDLDDIRAQERLGGRVTEMPSESLFFTDTKGDQNIRKELRLKPLYMDQLLKSDSAIPGLLSRRFIKKTTKVVDPDGQLTTKSCVVSKSAAKKIETLAKRKKGLGLSIGSDAEKKEAERRKQQDMVQRAKGGFDLWGSDAVQSNAVKDKYLARTLPPYIAKYTTSDYRPKLIPAVRISHPGTSYNPKGDDHQAAILIAADIEFKKIAQEEEAEKQLSYPKELDLLDDNDYFDDTDDEEDSQAEDSAAEGETAETLQDEAAAKKKNPARKTQNQRSRRARHIEYKRRLKMQHERNEFFEQINGVDAINESMEKQAEAMQLNQAKRQALRETLKETKPARVGKYSFQAAPFEIQLKDELSGSLRTLKPEGNIFRDRFKSLQERNIIEAYVPVTKKRRYQPKFTESHDYKRFK
The following text describes a protein:
Function:
Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase TorZ. Required for electron transfer to the TorZ terminal enzyme.
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein.
Sequence:
MRGKKRIGLLFLLIAVVVGGGGLLLAQKVLHKTSDTAFCLSCHSMSKPFEEYQGTVHFSNQKGIRAECADCHIPKSGMDYLFAKLKASKDIYHEFVSGKIDSDDKFEAHRQEMAETVWKELKATDSATCRSCHSFDAMDIASQSESAQKMHNKAQKDSETCIDCHKGIAHFPPEIKMDDNAAHELESQAATSVTNGAHIYPFKTSHIGELATVNPGTDLTVVDASGKQPIVLLQGYQMQGSENTLYLAAGQRLALATLSEEGIKALTVNGEWQADEYGNQWRQASLQGALTDPALADRKPLWQYAEKLDDTYCAGCHAPIAADHYTVNAWPSIAKGMGARTSMSENELDILTRYFQYNAKDITEKQ
The following text describes a protein:
Function:
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAGLPKGGNGTESPDRTSQFPLQRWQASSAPSGQSSALHHSVQVLPQSIPPSVAAQCSPSSHIDSVALLSALALEQHVDAATLNQDLVAVQEKTRVDLERIKVGGGDRDSSASSASVTEQNEQHDDLSTLSMRDDISALSIRDDISALSVQDDHSSRRSNVSSRQNPSMSVGQDLSAVRVELARSERLSPTLEYISALAHLTTFGILGVCIRYGLRILFSDYLHITSDSTPLLFDMPSNMVGCFFMGWVGVVLKRDIAAFSELLAIGLSTGLMGSITTYASWNQAMIVLITNGFWLRSIVSLIVGMELFQMSLMLGIDSAKLLRSVLTYIRRERIRRGWQKQWDSSPDNLRRRKIGMLIFLVTSTILWAGSLGLTVTDVNSAVRRRLWLSCLVGPPGVWARWCLARLNGQGIGRNQRLKWLPIGTFLTNLVASVLQAVLSVVILSNPEDASLLCRGLQIGLLGCMSTVSTFVTEIFSLRQSPKRWRAYAYLCLSLISTYCMGVIAYTVPVLTHPFAP
The following text describes a protein:
Function:
Orphan receptor.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAFCRVCDLKVLVAIVCGLLTAIVLGLGIWRIAVRIHRGTTIPTSSTPIAFCRNGGTWDNGRCICPEDWKGLRCTVANFCENSTYKSFTFPRISVGRYGPSFQTCDNSTLNAGNPMATRLCSLNENGEIELQNVTIGNCNENLETLEQQIGNTSIPFSNISMEVQILTSNASKLTPENITSATRVLGQIFNTSRNDSSEAKLVAVTTVSQLLDASEDIFQEAAATDDAAFETLIEQIETYSLSLGSEPVVKPNIAIQSGDIPSEGSTGVLFTVQKGASESLISGSTSISTSADGLNADEQTELQVFLNTSASNAKSCGFVVYQNSKLFQSKTFTTTSNFSQKIVSSTIDANKEDQSSSVTMVFNPKNNQQGFQLHSYACVYWNLSKKDWDTYGCHKEEGLDGFLGCHCNHTTSFAVLMSFKKYHKYPESLDILSILGCALSITGLAVTIIFQIVTRKVRKTSITWVLVSLCTSMLIFNLLFVSGIENPNKNSETSGSVSTVDSNNNEIPRQDIVFSSNPTCTVFAALLHYFLLGTFMWTGLSAAQLYFLLIRTMKPLPPRFILFISLIGWGVPAVVVALTVGIIFSQYKDDPEWELHYRQEQICWLAVPESTGLLASPLLWAFIVPVTIILISNIVIFVIIVVKVLWKNNQNLTSTKKSSSLKKILSTLSIAVVLGITWILSYLMLIEDDDIRIIFSYIFCLFNTTQGLQIFIVYTVRTKIFQSEASKVLKSLSSSTGTVKSLPPMIPLRLRVRMYNMLRSLPALNERFRLLEPSLVNNETTLSESDQENPSI
The following text describes a protein:
Function:
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA); Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Sequence:
MICVSLGRARHKRMIAEHQFLVEQGAQLVELRLDYISRAVDLKRLLNDRPGPVVATVRRKEDGGRWERSEQDRLMLLRSVIAAGAEYVDIEADVAAQIPRYGNTKRIISYHDFSGTPENLDELHEAMAAEDADIVKIACMANSFSDNIRMINLCKNAKIPTIGICMGEIGMLTRILANRVGSPFTYATFSSDKKLAPGQLNWKEMNSVYHYETIKEDTALFGVIADPVAHSHSPLIHNAAFVDAGLNARYLPLRVPKDDLPSFMRTCKELGIQGISITIPHKESALQYCTQAESSCTGIGAINTMIFNGDDRLGYNTDYRAAMDCIEESFKIERGTENSLQGKTALVLGAGGVSRAIAWGLRQRKCDVTISSRTRERAEMLAADIGCRVIDWEERHEAKVQLLINGTPIGMHPDVDNTPFNQSALNQFMVVFDTVYNPENTLLIKQATQKQSRVITGVDMFVRQAAYQFKLFTGQEASIELMRKKIKEATNPVRLN
The following text describes a protein:
Function:
Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis. Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes. Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs.
Subcellular Localization:
Secreted.
Sequence:
MCILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVRSSNNFGTILSSTNVGSNTYGKRNAVEVLKREPLNYLPL
The following text describes a protein:
Function:
Blocks voltage-gated potassium channels.
Subcellular Localization:
Secreted.
Domain:
Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).
Sequence:
MKAFYGILIILLFCSMFKLNESTTINVKCTSPKQCLKPCKDLYGPHAGAKCMNGKCKCYNNG
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSGFLTTLYHSVFRRSSTFALAVIGGAFLFERAADATADGLFDYLNRGKQWKDIKKNYE
The following text describes a protein:
Function:
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAPFLTRLLKALCESSLRILLLFFVVLFRSCQFVCVRVLRAERRKSVSGETVLITGASRGIGRCLALEFAKHGADTIVLWGRNEEKLSSVKKEVEEIGTSRCHFYRCDVGDRQQVYRTIQKVQEDVGTITILVNNAGVVHGGTLLETKDDKIEETLRVNTLSHFWTTKSVLPTMIARRRGHVVGIASTLGLFALPGVSDYVTSKFSLVGFYESLAVELKQQGHRDVGVMCVCPGHTTTDMFKDLTTQSFSLTPQQVAEQTIEAVKTNQRRVILPRVMHLTWILKSWLPGSWMWNTLYVTGALKDMEKFCTKR
The following text describes a protein:
Function:
Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.
Subcellular Localization:
Nucleus.
Sequence:
MGERKVINKYYPHDFDPSKIPRRRRPKNEQIKVRMMLPMSIQCDTCGTYIYKGTKLNSRKEDVVGEMYLGIQIFRFYFKCTKCSAEITFKTDPQNSDYTVESGASRNFEPWREQDEAADKEKRKRDAEEMGDAMKALENRAMDSKQDMDILAALEEMRSMKSRHAGVSVDQMLEILKRSAHEKEEKAIAELDEEDEELTKSITLRNSGFYVKRIEDDDEDNNDDLVPGQSSRTGKIDCSSESVTKPTDVLSKANGSEGVNKEGSKSWMPKFIVKPKSAGADPKRQKTESTAVQDNGKAPVGDQKSEPAMQTNVLQSLCQNYDSDDSE
The following text describes a protein:
Function:
Catalyzes pseudouridylation at position 35 in U2 snRNA stem-loop II region which induces particular conformation of the mRNA-U2 snRNA duplex and places the nucleophile in an accessible position for the first step of splicing. Also catalyzes pseudouridylation at position 56 in U2 snRNA. Also catalyzes pseudouridylation at position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr). Pseudouridine residues in tRNAs may stabilize the local RNA conformation, favor interactions with protein partners and play an important role in the stabilization of the codon-anticodon interaction with mRNA. Also catalyzes pseudouridylation of mRNAs in response to heat shock: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAR-3'.
Miscellaneous:
MISCELLANEOUS: Present with 4150 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Predominantly nuclear in 30 degrees Celsius and primarily cytoplasmic in heat shock.
Sequence:
MSDSSEATVKRPLDAHVGPSENAAKKLKIEQRTQADGIHEADVGITLFLSPELPGFRGQIKQRYTDFLVNEIDQEGKVIHLTDKGFKMPKKPQRSKEEVNAEKESEAARRQEFNVDPELRNQLVEIFGEEDVLKIESVYRTANKMETAKNFEDKSVRTKIHQLLREAFKNELESVTTDTNTFKIARSNRNSRTNKQEKINQTRDANGVENWGYGPSKDFIHFTLHKENKDTMEAVNVITKLLRVPSRVIRYAGTKDRRAVTCQRVSISKIGLDRLNALNRTLKGMIIGNYNFSDASLNLGDLKGNEFVVVIRDVTTGNSEVSLEEIVSNGCKSLSENGFINYFGMQRFGTFSISTHTIGRELLLSNWKKAAELILSDQDNVLPKSKEARKIWAETKDAALALKQMPRQCLAENALLYSLSNQRKEEDGTYSENAYYTAIMKIPRNLRTMYVHAYQSYVWNSIASKRIELHGLKLVVGDLVIDTSEKSPLISGIDDEDFDEDVREAQFIRAKAVTQEDIDSVKYTMEDVVLPSPGFDVLYPSNEELKQLYVDILKADNMDPFNMRRKVRDFSLAGSYRTVIQKPKSLEYRIIHYDDPSQQLVNTDLDILNNTRAKESGQKYMKAKLDRYMPDKGGEKTAVVLKFQLGTSAYATMALRELMKLETSRRGDMCDVKENI
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSVFGIGLAYAIATLVVMFSGMPIAFALGAVAVVFMGIYMPSASLDTVTQNVYEEMASITLLSIPLFILKGAAIGKSRAGQDLYLALHAWLHRVPGGLGVANVFACALFAAMAGSSPATCSAIGSAGIPEMRKRGYSGGFAAGIIAAGGTLGILLPPSITMILFAVAAEKSLGRLFLAGIGPGLLLVSLFGTYAVIRFRREYAAAEAIYRKGGPEAAILARDEYTLAERFSVLPRVIPFVLLLTGVMIALYGGYATPSETAGLGGLLALGLIAAIYSVWRPSDLAPIMKSTIRESTMLMMIIGMSLLYSYVMSYLHISQSVAESVVAMHLPRWGLLFAILVMVVVLGFFLPPVSIILMTAPIILPPLRAANFDIIWFGVVMTIVMEMGLIHPPVGLNIFVIRNVAPDIPLSEVIWGTLPFVLLMMLAVLLLCFVPGISTALPDLVMGPDGSR
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MATSEKKKGRLEALERRLTATPSTPQDQLPTASKKTATSNASPSTFVYPAPARSQAEIIEREKTYAQLCPSVVDGPLSSLLKHKRGKDSHAAIHDFLKILLEGSSKFQDVEETLESRVQENQVLLLDNPTNQVVPASEKARDRVHRNRAKRSREHMSLRQHRKCGSYGLPQEFREYQLFQPLQEMWTTYAKDLLSDCSETMMQTRLLTADLHGAVLSVVDSKNSSFAGTRGVMVRETENTFGIVTMNNKFRVIPKVGSIFRLEMENIKVTLFGNNLGLRSSATKAKKQKLTSTIEL
The following text describes a protein:
Function:
Catalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate (DOHNAA) and 2-hydroxy-hexa-2,4-dienoate (HHD). Is also able to catalyze the hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) and the synthetic analog 8-(2-chlorophenyl)-2-hydroxy-5-methyl-6-oxoocta-2,4-dienoic acid (HOPODA).
Miscellaneous:
MISCELLANEOUS: Cholesterol metabolism contributes to the survival of M.tuberculosis in the host by helping the bacterial multiplication during earlier stages of infection and to the dissemination of the pathogen in the host.
Sequence:
MTATEELTFESTSRFAEVDVDGPLKLHYHEAGVGNDQTVVLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFNRYAAMALKGLFDQLGLGRVPLVGNSLGGGTAVRFALDYPARAGRLVLMGPGGLSINLFAPDPTEGVKRLSKFSVAPTRENLEAFLRVMVYDKNLITPELVDQRFALASTPESLTATRAMGKSFAGADFEAGMMWREVYRLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFNKLTIEFLGGGR
The following text describes a protein:
Function:
Required for meiotic chromosome segregation.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDFKSRKYKIKKHPKDCKLHAKKYRGTLNSKGKNDNDCLIMCMRCRKVKGIDSYSKTQWSKTFTFVRGRTVSVSDPKVICRTCQPKQHDSIWCTACQQTKGINEFSKAQRHVLDPRCQICVHSQRNDGDDNLESDKFVDPFIGDDSDLDDDIYIHDKQTINSEYADDVSDNTDEERTESKGQQESNSAEEYDDDDSDEDRMEEIFQQFKKEKQIV
The following text describes a protein:
Function:
May act as a potent antibacterial protein that may play a role in the innate immunity.
Subcellular Localization:
Secreted.
Sequence:
MLSSILLWGLIALIGTSRGSYPFTHSMKPHLHPRLYHGCYGDIMTMETSGAACDITRLMNCGIRGSEMFAEMDLRALKTYQILIKEVGLRHCVDPALIAAIISRESHGGAVLKDGWDHRGLKFGLMQLDKKIHHPVGTWDSKEHLLQAVGILTDKIKAIQKKFPTWNVAQHLKGGLSAYKSGIDAIVTPVDIDNDLVNDLLARAKFYKRHGF
The following text describes a protein:
Function:
Metalloprotease which cleaves the carboxyl terminus of procollagens, such as sqt-3, to mature collagens (By similarity). Involved in cuticular collagen maturation.
Subcellular Localization:
Secreted.
Sequence:
MHKIFIIFGLLSLCAAHSLRDLSNKDEEDPPSSAPGVRKRRMMSEEDQKTVDYYMDKLNKLADEKHPEEIERHKNPELVAWDRKRDSVLNPEEQGKFFQGDIVLYPEQAKALYEQALTEGKTRVKRKFIGSNLRRWDASRPIIYAFDGSHTQREQRIIELALEHWHNITCLNFQRNDQANSGNRIVFTDVDGCASNVGRHPLGEEQLVSLAPECIRLGVIAHEVAHALGFWHEQSRPDRDQYVTVRWENIDKDSKGQFLKEDPDDVDNAGVPYDYGSIMHYRSKAFSKFDDLYTISTYVTDYQKTIGQRDQLSFNDIRLMNKIYCSAVCPSKLPCQRGGYTDPRRCDRCRCPDGFTGQYCEQVMPGYGATCGGKISLTRSTTRISSPGYPREFKEGQECSWLLVAPPGHIVEFQFIGEFEMYCKIRHSLCMDYVEVRNSTDFANTGMRYCCYGTPPTRIRSATTDMVVLFRSFYRGGKGFEARARAVPEAGNWNSWSPWTACSATCGACGSRMRTRTCPPGNACSGEPVETQICNTQACTGMCAQKREEEGQCGGFLSLLRGVRCRQEKTVMAPCENACCPGFTLQRGRCVR
The following text describes a protein:
Function:
Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
Sequence:
MPVIKDAVCSLCGSLCDDITVTVEDNKITKIENACILGHSKFVGMFEHDRIETPMIRKDGELVPVSYEEAIEAAAKILVNSRRILSYGWCSTSCEAVSGAIELAEETGSVIDSTANVCHGPSALAAQEKGSPSASLGEIKNRADVIVFWGCNPVHAHPRHMSRYSSFSKGFFTEKGRKGRTMVVIDVRKTDTAKLADNYVEIEQGSDLLLITALRSIVNGHEDVVPETVAGVPKAEVLELAETLKNAKFVCIFFGMGVTQSRSKYKNGDAVSSLISDLNQHTKAVMIGMRGHYNVTGFGQVATWETGFPMAIDFARGYPYYNPGETGANDLLVREEPDAAIIAAADPGAHFPQKAVRHLAKIPVIQIDPYANPTTEIADVVIPSAIVGIEAEGTAYRMDAISLRMKKLIDTRFKTDEEIVKDLTAKVRELKRGA