lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSGRHNNKLPTNLPQLQNLIKRDPQSYTEEFLQQYRHYQSNVQIFKLKPDKPNKELAELVMFLAQVAHCYSEQLANFPQELKELLLCHHTVLEHDLRMTLYTHIVSDIKNINAKHKNNKVNTTLQNFMYTMLRDSNATAAKISLDVMIELYRRNIWNDTKTVNVITTACFSKVTKILVAALKFFLGKDEDEKNSDSESEDDGPSAKDLILRYSTGKKSSKNKKKMEKALKVLKKNKKKKRAEVFNFSAIHLIHDPQDFAEKLLKQLEDSKERFEVKIMMMELISRLVGIHELFLFNFYPFVQRFLQPHQRGAEVTKILLCAAQASHQLVPPETIQPVVMTIANNFVTDRNSGEVMTVGINAIKEVVGRCPLAMTEDLLQDLAQYKSHKDKNVMMSARGLIQLFRTLNPNMLHKRDRVRPWMDSGITGKFIIFFSPITFVYWLPIRVQAVEMSHSQWDLWFNILHAHLQFKDGHSLTVNYISMKNTSLPTLADKLQSIPAEERKARAVAMSTSRLLTQEDFRKIRLAQLAKEVSSAPGKNQKRKSADSDDESRGELLSLRNIEHLHKKPKSDKETRLATAMAGRTDRKEFVKKRAKLNPFASTTNKEKKKKKNFMMMRYSQNIRTKGKRSFREKQIALREALLKKKKQHMK
The following text describes a protein:
Function:
Involved in p-cresol and 2,4-xylenol catabolism. Catalyzes the oxidation of 4-hydroxybenzaldehyde and 4-hydroxy-3-methylbenzaldehyde to yield 4-hydroxybenzoic acid and 4-hydroxy-3-methylbenzoic acid, respectively.
Sequence:
MSQRLAAYENMSLQLIAGEWRVGKAGRDLDVLDPFTQEKLLQIPLANREDLDEAYRSARQAQVAWAACGPSERAQVMLNAVRIFDERRDEIIDWIIRESGSTRIKAQIEWGAARAITQESASLPSRVHGRILASDVPGKESRVYREPLGVIGIISPWNFPLHLTARSLAPALALGNACVIKPASDTPVTGGLLLAHIFEEAGLPKGVLSVVVGSGSEIGDAFVEHEVPGFISFTGSTQVGRNIGRIAAGGEHLKHVALELGGNSPFVVLADADLDQAVNAAVVGKFLHQGQICMAINRIIVEDSVYDEFVNRYAERVKSLPYGDPSKPETVVGPVINAKQLAGLQDKIATAKSEGARVMVEGEAQGNVLPPHVFADVTADMEIAREEIFGPLVGIQRARDEAHALELANSSEYGLSSAVFTSSLERGVKFARGIRAGMTHINDIPVNDEPNAPFGGEKNSGLGRFNGDWAIEEFTTDHWITVQHAPRRYPF
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Mitochondrion.
Sequence:
MRSTTRFRNASSRFQRFARLNSARPFVVTILRQQSPFRRLYASTSTTKYTVEQSVERNAPPQWLSFKGFNGNEEKVPVIQACLNAGDISRALQILQKTIGHSTTDEAVHLVHVFLKHSVSCVPVEEVISYYEQLLKTRRFRADAISYAILCQAAMVQEKASNSSFPILRKLVRNWRRMNHSLSEILMVGSLVFSKKEASVLAELFRLPLHVYSGEERDKMQLADLYDSISKNFANAQPDFVSQDQLLSVKTRNIGLDMLKNTLSAIQANSKDQLEIDRAALDIGEEADPYNAARQRLMEKKALESSIAEWRHSYNEILRRGENPPHSRSLNALLYVWYEKLEALIQEEFRQIEDSENNKASPYKSRTRAEYAQYLKLLSPSKLAAITVLEMLTFVTNKRYCTGVRSTFALMSVGRAFEKEYFSEQLQKIEAEGNLPKSVDSKKLFSSPRLFNSFVKKIRDNEDNGIVQSSLYQPWSPNILVKVASVTVSLLINSAKIRDSALDPETKSTVFQDSSAFQHGYRYLAGRKVGVIVAHPVLYDILASELSGAHLPPYRLPMLVKPRPWLMWNSGGYYYSSESVLRFKESHEQLLYLKAASDSGQLKDLLEGLTALGNVGWKVNRKVYDMLVKIWNTGESFLSIPSANTTLDIQEMPEKSIDPSARAEWLRMLKERSLDFASQHSQRCEFNYTLEIAKAFLHETFYFPHNVDFRGRAYPIPSHLHHVNSDFCRSLLIFAEGKPLGEEGFQWLKVQLANLFGKNKSTIQERIDFVDNHLQDIFNSVDKPLDGEQFWTKADDPFQALAVCFEIADAIRSGDPSSFISHVPVQQDGTCNGLQHYAALGGDPEGAREVNLEPSNRPNDVYAAVAARVISILKKEAAAGDPMAELLKDRVTRTVIKQPVMTNVYGVTYVGARAQIEKQLKLQEDIPKDLLRDASAFLAKRVFQSLRALFKRAHEIQDWLADCAALIAHSVPEEALKQKELDKMTAVVWTTPLNLPVVQPYRKFPSKQITTNLQSVYLEDPDSNAPVDPRKQTTAVPPNFIHSLDATHMFMTCLKCKKRNITFVSVHDSYWTHAASVAELNGLLREAFVELHSRDILGDLKREFEDRYKNHYVHNHYPVDSPAGQYLLQQGATAKRSVVKGWAPLTFPEVPERGTFDIRSVLHSQYFFS
The following text describes a protein:
Function:
Can transport glutamate, aspartate, glutamine, asparagine, serine, alanine and glycine.
Miscellaneous:
MISCELLANEOUS: Present with 432 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKMPLKKMFTSTSPRNSSSLDSDHDAYYSKQNPDNFPVKEQEIYNIDLEENNVSSRSSTSTSPSARDDSFAVPDGKDENTRLRKDLKARHISMIAIGGSLGTGLLIGTGTALLTGGPVAMLIAYAFVGLLVFYTMACLGEMASYIPLDGFTSYASRYVDPALGFAIGYTYLFKYFILPPNQLTAAALVIQYWISRDRVNPGVWITIFLVVIVAINVVGVKFFGEFEFWLSSFKVMVMLGLILLLFIIMLGGGPNHDRLGFRYWRDPGAFKEYSTAITGGKGKFVSFVAVFVYSLFSYTGIELTGIVCSEAENPRKSVPKAIKLTVYRIIVFYLCTVFLLGMCVAYNDPRLLSTKGKSMSAAASPFVVAIQNSGIEVLPHIFNACVLVFVFSACNSDLYVSSRNLYALAIDGKAPKIFAKTSRWGVPYNALILSVLFCGLAYMNVSSGSAKIFNYFVNVVSMFGILSWITILIVYIYFDKACRAQGIDKSKFAYVAPGQRYGAYFALFFCILIALIKNFTVFLGHKFDYKTFITGYIGLPVYIISWAGYKLIYKTKVIKSTDVDLYTFKEIYDREEEEGRMKDQEKEERLKSNGKNMEWFYEKFLGNIF
The following text describes a protein:
Function:
Required for proper chromosome segregation during mitosis and error-free mitotic progression.
Subcellular Localization:
Chromosome. Nucleus, nucleolus.
Sequence:
MAVDAVEEYMPPQYPKEFDSTDLRRLVGVAPKGYKVNPIKSQKRKRVEEPDEEPMEEETAMQQDEPQADVAQAGKRQKADDKTWRPVSGKVWKAPGQRASKVMKANASSNKSWGRRMTEKAANKALKETKAEALAETKAKRKAAADQRKAARERKQANQAKSAVTQKITKASTVKKMLKDKKQRKLLRTADTN
The following text describes a protein:
Function:
A hormone that controls sex pheromone production in females and pheromone responsiveness in male. Also mediates visceral muscle contractile activity (myotropic activity) (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MIGFAVFSSFNRFTTIFVCVLLCVVYLLSYASGEYDGRDSSSGSNNDRAPSNEFGSCTDGKCIKRTSQDITSGMWFGPRLGRRRRADRKPEINSDIEAFANAFEEPHWAIVTIPETEKRQITQFTPRLGRESGEDYFSYGFPKDQEELYTEEQIYLPLFASRLGRRVPWTPSPRLGRQLHNIVDKPRQNFNDPRF
The following text describes a protein:
Function:
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
Subcellular Localization:
Cytoplasm. Note=May associate with membranes.
Sequence:
MSDKHITLHDDAPERSILARLILPDTVVEEDPLEELHGLATTSGTEVVDELIQRRSTPDHSTYLGKGKVEELRLMVERHEADVVIFDNDLSPAQIRNLEKKTNAKVIDRTELILDIFAAGARTHESRLAVELAQLEYSLPRLKRMWTHLSRQSMGVGMRGPGEKQLEVDRRLAQKRIHDLKTELKSVELRRERQVAARSDSPTVSLVGYTNAGKSTLMNALTDAGVMAQDKLFATLDTRTRRWHLPEWGHVLLSDTVGFIRDLPHSLVASFKSTLEETRQAELLLHVADASSSQVFEQISAVYQVLEELGIEAKDTLLVLNKIDAITSPRDLNRVLDRYPNAIPVSARSRSGLKPLAQAVGEALSREFLDVEIGVAHHDGKLLSFLSATGKIESREFGNDHVIVRVRMPASAMGTVNRSALSVTPTTLEMWKQTASEEELEDSSEDSSEESVERSSDVA
The following text describes a protein:
Function:
Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition.
Subcellular Localization:
Mitochondrion.
Sequence:
MFAGRLMVRSIVGRACLATMGRWSKPQAHASQVILPSTPAIAAVAIQCEEFTANRRLFSSQIETESTLDGATYERVCSDTLDALCDYFEELTENASELQGTDVAYSDGVLTVNLGGQHGTYVINRQTPNKQIWLSSPTSGPKRYDFVGTVAAGRWIYKHSGQSLHELLQQEIPGILKSQSVDFLRLPYCS
The following text describes a protein:
Function:
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MRSRSNSGVRLDGYARLVQQTILCHQNPVTGLLPASYDQKDAWVRDNVYSILAVWGLGLAYRKNADRDEDKAKAYELEQSVVKLMRGLLHCMIRQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQMTASGLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIWERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQSILNSLLPRASTSKEVDASLLSVVSFPAFAVEDSQLVELTKQEIITKLQGRYGCCRFLRDGYKTPKEDPNRLYYEPAELKLFENIECEWPLFWTYFILDGVFSGNAEQVQEYKEALEAVLIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFLAPGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKTILKDKGIYVETIAEVYPIRVQPARILSHIYSSLGCNNRMKLSGRPYRHMGVLGTSKLYDIRKTIFTFTPQFIDQQQFYLALDNKMIVEMLRTDLSYLCSRWRMTGQPTITFPISHSMLDEDGTSLNSSILAALRKMQDGYFGGARVQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDDNYDYLESGNWMNDYDSTSHARCGDEVARYLDHLLAHTAPHPKLAPTSQKGGLDRFQAAVQTTCDLMSLVTKAKELHVQNVHMYLPTKLFQASRPSFNLLDSPHPRQENQVPSVRVEIHLPRDQSGEVDFKALVLQLKETSSLQEQADILYMLYTMKGPDWNTELYNERSATVRELLTELYGKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSHQKHLTVGLPPEPREKTISAPLPYEALTQLIDEASEGDMSISILTQEIMVYLAMYMRTQPGLFAEMFRLRIGLIIQVMATELAHSLRCSAEEATEGLMNLSPSAMKNLLHHILSGKEFGVERSVRPTDSNVSPAISIHEIGAVGATKTERTGIMQLKSEIKQVEFRRLSISAESQSPGTSMTPSSGSFPSAYDQQSSKDSRQGQWQRRRRLDGALNRVPVGFYQKVWKVLQKCHGLSVEGFVLPSSTTREMTPGEIKFSVHVESVLNRVPQPEYRQLLVEAILVLTMLADIEIHSIGSIIAVEKIVHIANDLFLQEQKTLGADDTMLAKDPASGICTLLYDSAPSGRFGTMTYLSKAAATYVQEFLPHSICAMQ
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
RPGAAPDTNAPLRTGDQFYIVLKGRLESHSLLFSAEVDAIDNDVPQEPGSTAAYVEFKTSRIITHPNQERNFFGKKLLSCWSQSFLAGVPRIVFGFRTADGEVQSVEEFSVEEMPSLAEGQWSDRVCLSFLDKMLSFVKECVTEDDPNVVYLFTYNPKEDSRVVCKKLSDPGKFHILTSSYLDAFSH
The following text describes a protein:
Function:
Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).
Subcellular Localization:
Cell outer membrane; Lipid-anchor; Periplasmic side.
Sequence:
MSILLQGERFKKRLMPILLSMALAGCSNLLGSNFTQTLQKDANASSEFYINKLGQTQELEDQQTYKLLAARVLIRENKVEQSAALLRELGELNDAQKLDRALIEARISAAKNANEVAQNQLRALDLNKLSPSQKSRYYETLAIVAENRKDMIEAVKARIEMDKNLTDVQRHQDNIDKTWALLRSANTGVINNASDEGNAALGGWLTLIKAYNDYIRQPVQLSQALQSWKNAYPNHAAATLFPKELLTLLNFQQTNVSQIGLLLPLSGDGQILGTTIQSGFNDAKGNSTIPVQVFDTSMNSVQDIIAQAKQAGIKTLVGPLLKQNLDVILADPAQIQGMDVLALNATPNSRAIPQLCYYGLSPEDEAESAANKMWNDGVRNPLVAMPQNDLGQRVGNAFNVRWQQLAGTDANIRYYNLPADVTYFVQENNSNTTALYAVASPTELAEMKGYLTNIVPNLAIYASSRASASATNTNTDFIAQMNGVQFSDIPFFKDTNSPQYQKLAKSTGGEYQLMRLYAMGADAWLLINQFNELRQVPGYRLSGLTGILSADTNCNVERDMTWYQYQDGAIVPVAN
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Cell membrane. Endomembrane system; Multi-pass membrane protein.
Sequence:
MANNDKNKEKENEYFLDANEDETDIEAVNYDSDSSNNRGSYDDDDQQPESFTSQQWPQTYNEAIDPLTIAAAPNLGSILRGPSVLYSSFVGSFSSKSYLELHDGKTSFLSGNQIQEGFPTTWWEKASIQMQIPEELPIGYGCTFTQTIFNGINIMAGVGLLSTPDTVKQAGWVSLVVMLIFAVVCCYTAELMRHCFQSREGIISYPDIGEAAFGKYGRVIISIILYIELYSYCVEYIIMEGDNLAGLFPGTNLHWGGLNMDGKHLFAILAALIILPTVWLKDLRIISYLSAGGVIGTALVATCVFVVGTRKDVGFHHTGQFVNWSGIPFAFGIYGFCFAGHSVFPNIYQSMANKKDFTKAIIICFVLPFLLYGGVGAMGFLMFGEGTLSQITLNLPRDAFASKVSLWTIELLPHSISSTNWCFILLRTALVISTVCAAFVIPFFGLVMALIGSLLSVLVAIVLPALCFLKIVGKKATSTQVVLSVVIAAWGVVCASLGTYSSLLKILQIS
The following text describes a protein:
Function:
[XK-related protein 9, processed form]: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKYTKQNFMMSVLGIIIYVTDLIVDIWVSVRFFHEGQYVFSALALSFMLFGTLVAQCFSYSWFKADLKKAGQESQHCFLLLHCLQGGVFTRYWFALKRGYHAAFKYDSNTSNFVEEQIDLHKEVIDRVTDLSMLRLFETYLEGCPQLILQLYILLEHGQANFSQYAAIMVSCCAISWSTVDYQVALRKSLPDKKLLNGLCPKITYLFYKLFTLLSWMLSVVLLLFLNVKIALFLLLFLWLLGIIWAFKNNTQFCTCISMEFLYRIVVGFILIFTFFNIKGQNTKCPMSCYYIVRVLGTLGILTVFWVCPLNIFNPDYFIPISITIVLTLLLGILFLIVYYGSFHPNRSAETKCDEIDGKPVLRECRMRYFLME
The following text describes a protein:
Function:
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MFCAISGEAPREPVVSIKSGLLFEKSLILKHIADCGTDPENNEPLTVDDLISVKSASKVIKPRPPVATSIPTLLLTLQNEWDSVMLETHQLKQHYHSTRLELANALYEYDAAKRVIARLIKERDDARSTLSQFKASHGTSQSNGHAVASDNTTADVDMAPVTESALPEAMVQTINKTSEELSQTRRKRKAPETLATIEEIASMTEIAENTSIHTAKEPTSLSLDLFTADIDGNSISWALLAGKDGSVYILDASNKCESEISHAKAHSKPVTCAVWRGASKKSFITTSFDHTVKLWNVDRVKNSYKIKSAIVFDAHKDRATMVSVHPSGEFAISVGMDSIWAILDLDSGKIVASVSHPEITSGYTTVQFHPDGFLLGTGTNDSLIHLWDTKTLTKAHTFTGHLDGTITSIAFSENGYYLASTSDKETCVRFWDLRKLTNFYTLELGPIEGVTGIARVRFDHSGQYVGICVGNELRIHLVKKWDHVATFTNNGASLTDFAFGVDAKYVVMVGQERKLSFFSNAE
The following text describes a protein:
Function:
As a component of the decapping complex, involved in the degradation of mRNAs. Promotes P-body formation. Translational repressor.
Subcellular Localization:
Cytoplasm, P-body.
Sequence:
MAAEAPPSASASSSSAPRPPAAAASASGGGAAGSAESYIGSLISLTSKSEIRYEGVLYKINTEESSIGLRNVRSFGTEGRKKDGMQIPASDKVYEYILFRGTDIKDLQVKSSPPPPPPQAASLHNDPAIIQSHYSQPASTSSNLPSAGGAVLPDLSSQAVQYGLQRPTFQSNLPLYQPGNAPRGSSAAPPAGNAPWGSSAEPPAGTTLSVPSMYWHGYYAPSSGLPPHLQQPLLLQPTPGLSVPQNLQYPGLNPSLPSGMQKLSELQPSLMPPINSQGSSGILPTTTAPASATLLAPESSKPQVPNMGSLFTPATSLGATFPYPSQPTPVAETSATVSQNITSFSSNKATALPGSTLSYQTASQSVSSTIAPSSSAQVEMAVPLLASSGQLLQNTSSMLSSSHSMQAPLQVASKEVKPVEPKAKVAEPLLPDPLLPDPPSQSLPENKEPILPLPKQTPQKYNGSGLHNHHNFRGRGRGRGSAFSQSVTTFTEEFDFTAMNEKFNKDEVWGHLGKKSQSRDKDGEVGDDVFDEDLEVEETDNPELSVKPVYVKDDFFDSLSSGTFGRGGPNGRDFWRISTAQATLPWWRPRLPWRWTFPRFILWWQRLWKHRDRRLWKHRDRWPWKFLFSPGLWERLIIAEMCRQPYLWVL
The following text describes a protein:
Function:
Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane.
Sequence:
MLQLLAVTFFLSGIVTTLLGNVSPAIQKLSYYGKTLTQKTNSTLALPKPWFIHFYILAAFLGYYSLFIVYDSFSDNHILIDVLGLLDSPISANNMFANGWTDWMDDLVSNINEWKLISTTHVQKPLTTLVLLLLGTIQGTRRLYECVYVMKYKVKTGASRVAEEQRKKKEGQTAEIESRESQMLLTHYLVGMGFYVAVFCSLWATGVAGVRDMEEWDFDYNSVGLSIAISLFLVASTLQYLCHVHLSSLIKYSLPTFWPFKITVCPHYTCEALIYMSYIGVSLSTGSTPNYGLLLAPLFTLTVLTTSAKNSKDWYKQKFPEYNVRWLTIPGVL
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
Miscellaneous:
MISCELLANEOUS: In contrast to the orthologous protein in animals and plants, this protein does not contain a HMG box DNA-binding domain. This function may instead be provided by the HMG box of the associated NHP6 protein in the FACT complex of fungi.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MSTVTFENIFHGDSADLGKLRFNPVGFGWKAYQSEDNNPTTYNGSDIRHATWFRVARHFQLRLGMRNSEKPRISFDGFKRDDLDKIKRTLQEYFNITLETRDTSLKGWNWGEAQVKGSDLVFQVQGKTAFDVPLSQVANSNIAGKYEVALEFNPPSNYKFDPKDLNKRPPDEMVEMRFYIPGKSMKKAGSDAGSGGEETELDEEGNEVSAADAFHSLIKEKADIGAVVGDSIVVFEDCLILTPRGRFSIEVYADSIRLVGKSTDHRVPFTSIHRIFLLPKLDDLHVQLVLGLDPPIRQGATRYPFLVAQWPKDEVVNAELNLTDEELAQYPDLEKTYEATTFQVVSRVLKALTGKKVTPPGSLRNAQGLNGIRANVKAVQGELYFLEKGLIFISKQPILIDFSKTDSISFSRVGGGVASARTFDMRVVSKTGGADHVFSAINKQEVGPISSFLQSKNIRLKNEMEEAIVDIDEPFSDDDEEMESPSEDERPSKAKNDKSKTKPVKKAADDDEDESDDEDFEDESSDGGSPSESDSDDDSGMASDASDPMMEELRKKTQAKRTKAKETSGSGSEDEKPKKKKAKKDDDE
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLLCVVIQGVTLINANITPHWHQRKMHVLAPIVALFLLATTAFAQVFDAEFIRENLPSLSRSKGVIRLNDQNFQKLVGGPRDYHFVVLLTAEAAQFGCHLCKEFGPSFDLLAASYLTDHPDSDNVFFGIADFSESQATYRGLDLTAAPNFWIFPPTEKNIPIGGEHYKFSFPQVDNLEVPAGNFIREVTGKDFKIHYPFRWDKLFSAILTIAGVGVGLVVFKKQLKVFFAKRNVWAAATLVLILMFVAGHMYNIIRKTQYIVADGNNNPVYFVGGFSQQIGVETQIIALTYALLAFCVISLALRAPSLNTGSKQVGVTLALCIVILVAYSFLLAKFHIKNGGYPYHLLNIF
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MTKRVKRNVASTPTSTATPASSLAPQELSPSPHASKRGKTRPDRAPAPRTSFSLTACRKWFATYLSQDGDKQIEPAGVMKLCEDLNVTPENPVLLVLASDAGCERMGYFTWNEWLSAMNKYQCASAGSLKAKLPLLEARLTTPTELDVIYKFAYDFARSAQDNPAQRSLDKDLAIDMWQLLLRRGWPLLPTFLNFVRSNAIKVVTRDQWRSLLAFARENTDTVENYDETQACTLIFLSFSLSLSLSLSLSLSLSLSLSLSLSLSLFLSFSLSTNLTWMTNAECFV
The following text describes a protein:
Function:
Integral membrane transporter that imports quinic acid to be catabolized as a carbon source.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell membrane.
Sequence:
MSILALVEDRPTPKEVYNWKIYLLAAVASFTSCMIGYDSAFIGTTLALSSFREEFGFSTMSKTAVNLVSANIVSCYQAGAFFGAFFAYPIGHFWGRKWGLLFAGTIFTLGAGLMLGANGDRGLGLLYGGRVLAGLGVGAGSNITPIYISEMAPPSIRGRLVGVYELGWQIGGLVGFWINYGVSETLAPSHKQWIIPFAVQLIPSGLLLIGAVFLKESPRWLFSRGRREDAIKNLCWIRQLPADHIYMIEEIGAVDQALEEQRTTIGLGFWKPFKAAGTNKKVMYRLFLGSMLFFWQNGSGINAINYYSPTVFKSIGLHGANTSMFSTGIFGVVKTVVTFVWLLYLIDRVGRRLLLLIGAAGAAVCLLIVGAYIKIADPASNPTQEMTGGGIAAMFFFYLYTVFYTPSWNGTPWVMNSEMFEPNMRSLAQACAAASNWLWNFLISRFTPQMFAKMEYGVWFFFASLMLLSIVFVFFLVPETKGIPLESMDVLFESKPIWRAHATVLAKLREDEEQFRHDIEESGYSKTGEQQVEHVSEDLPKV
The following text describes a protein:
Function:
Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
Subcellular Localization:
Cytoplasm.
Sequence:
MEDLTPQQTKELIDFLKFERQNRDETRGEISVELNELLKEKFNRDDTYGGKEALKTLAEFPEAIAKTMHTELIHMRDINVNLIRQILLDAQKENLLLELSIPDLENEASTDAANLLAGKLIMNADKMPAAKETKDEAPVDEKIDVEALMAENEKLRAQLQQNKRQWPEFIEAQNKLKNLNTEVHDLRHKLGKE
The following text describes a protein:
Function:
Involved in the transport of siderophore enterobactin and so has a role in iron homeostasis.
Subcellular Localization:
Endosome membrane; Multi-pass membrane protein.
Sequence:
MLETDHSRNDNLDDKSTVCYSEKTDSNVEKSTTSGLRRIDAVNKVLSDYSSFTAFGVTFSSLKTALLVALFLQGYCTGLGGQISQSIQTYAANSFGKHSQVGSINTVKSIVASVVAVPYARISDRFGRIECWIFALVLYTIGEIISAATPTFSGLFAGIVIQQFGYSGFRLLATALTGDLSGLRDRTFAMNIFLIPVIINTWVSGNIVSSVAGNVAPYKWRWGYGIFCIIVPISTLILVLPYVYAQYISWRSGKLPPLKLKEKGQTLRQTLWKFADDINLIGVILFTAFLVLVLLPLTIAGGATSKWREGHIIAMIVVGGCLGFIFLIWELKFAKNPFIPRVYLGDPTIYVALLMEFVWRLGLQIELEYLVTVLMVAFGESTLSAQRIAQLYNFLQSCTNIVVGIMLHFYPHPKVFVVAGSLLGVIGMGLLYKYRVVYDGISGLIGAEIVVGIAGGMIRFPMWTLVHASTTHNEMATVTGLLMSVYQIGDAVGASIAGAIWTQRLAKELIQRLGSSLGMAIYKSPLNYLKKYPIGSEVRVQMIESYSKIQRLLIIVSISFAAFNAVLCFFLRGFTVNKKQSLSAEEREKEKLKIKQQSWLRRVIGY
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MEAESLVDRPSTHPGEIEDQEDLPKEKLSEQLIRHWINERFAPEVLAHQEELLEKILSRIQQQSLALDVLSNNPEELSSDDHFRLMLIETEIEHLRYICKAYARCRMHKLDKFFDHCLMDPETRSRLSKVDLEYCSREQTLVHNLLYDSVLDQLPIKYRKLDEDHMIIRPNLDQSVFIIVRSSCGPVYIPHEEPLMLEKGSIHFINYRSIKSFLESGHVKLG
The following text describes a protein:
Function:
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Plays a role in the regulation of lipid metabolism (By similarity).
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Note=Localized at the apical membrane surface of renal proximal tubules.
Sequence:
MQGARAPRDQGRSPGRMSALGRSSVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWRKPMPQRKDKVR
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
MCAEHGPKDKPNMNPDFVLCPFHPKHVVRVNDLDLHRQTCLFRPQPLPPYHVKNINSGSNLDSVSQHDMHVKILDILSKEDLFALIQKLDTAYHQAIQHDHIFMRDGIPLHVLTHESLNQRLNETQHGKHAVQQASLMGHLHEKNLIGEHRCYAEFGCGKGELSKFIYASVPQHTRYLLIDRKVMKLKVDRVFRANADWERVTIDIRDFNLQGVERIQQMPVIAISKHLCGVATDLTLKCLSNYKKNCESDSSNPSLVQGMVIALCCHQLCKFDDYINPGFLSKYGIGAKEFDILAGVSTWALCGERSTSKSTSSKESSSVDPTHELGTESNEPVAVP
The following text describes a protein:
Function:
Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm.
Sequence:
MSAPVELTDQWEEDKMSKENRRMGVPTAAMAGSSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAALITNDSKITVLKQVQELIINKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRDENVNVVKKAILTMTQLYKVALQWMVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIRTHAIKFVEGLIVTLSPRMADSEVPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLLKFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKNLKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSGKDARKRPRDDSDSALKKMKLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMVYLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEKVVKPESVLIKRRLSAQGQAISVVGSLSSMSTLEEEAPQAKRRPEPIIPVTQPRLAGAGGRKKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFDSGLKAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASGTLDKYEDCLIRLLSGLQEKPDQKDGIFTKVVLEAPLITESALEVIRKYCEDESRTYLGMSTLRDLIFKRPSRQFQYLHVLLDLSSHEKDKVRSQALLFIKRMYEKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAAPWTEETVKQCLYLYLALLPQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPELLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEKKEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMKSIIKATNLCFAERNVYTSEVLAVVMQQLMEQSPLPMLLMRTVIQSLTMYPRLGGFVMNILSRLIMKQVWKYPKVWEGFIKCCQRTKPQSFQVILQLPPQQLGAVFDKCPELREPLLAHVRSFTPHQQAHIPNSIMAILEASGKQEPEAKEAPTGPLEEDDLEPLALAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGAPSSSSSSSARPGPPQPEEAIDFREEGPECETPAIFISMDDDSGLTEAALLDSSLEGPLPKEAAASGLTAKEERSPQTLTPAGEDTVKTPSPAAAEEAGESENKGNS
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).
Miscellaneous:
MISCELLANEOUS: The protozoan parasite evades the immune response of mammalian hosts and digestion in the gut of the insect vector by means of its coat proteins tethered to the cell surface via GPI-anchors. GPI10 is essential for growth of mammalian stage bloodstream form, while procyclic form (insect stage parasites) are viable but grow slower, suggesting that inhibition of GPI synthesis may be an effective chemotherapy against African trypanosomiasis (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPWWLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVFFPAVVALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFRMGATLDELLAKRELELAEEMRQSKTKGFSYFREVFVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLTLQQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFTRGLFRIVLTGLIVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITAAFVLVRWSRTSAVVVKMNRLFVLFNIVMIYLMGYVYRRGPLDVMAEVRDGPRINRLDVIATCYTVPGYSYMHRKVNHLGFVDCSIDLDEKTGLPKVTEDIMFRRYPKEYVLWRYDGKHSFNMGDLEESRKASELQSVVMPKSAPHPDAMVMTRAVAKEIEEPFLKRHGYRLYRTFLHSPLTLAPYEDIYIQMWVKVTK