lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly cytoplasmic. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase and telophase is localized at the midbody region. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1. Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis.
Domain:
The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
Sequence:
MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHELPASEGEVWSLPVPAERRPSPGPRKRQSSQYSDPKPQGNRPSTAVRVHRPSTHNLHNDRGKAVRSREKKEQNKGREEKNKSPAAATEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSREEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFGSC
The following text describes a protein:
Function:
May be involved in vascular wall and kidney homeostasis.
Subcellular Localization:
Secreted.
Sequence:
MSPVCIVLLVFVSIPCEGREGVGGSDQDWGYITVRPNAHMFWWLYYTTYNNVSNYTDRSLIIWLQGGPGMPASGFGNFLEIGPLDANFQGREGSFIENFNVLFIDNPVGVGHGGETAEDLYNFLKIFLDETHPEFKNVPLYVFGESYGGKMATEFVYRLKQKEKFENLTLCNLKALALGGAFISPISYISNYAAIAFHLGLVNKRVSARIDELTKQIQVLINKEAYEEASDIYDNILNELDLILNVDFHNIVRKINATWMTDFQKITSTLEHVMNSKVKDKLNITADVYWEYNSDVYNSIKGDVLKSVTDKIETILNTTDVKVLVYNGMLDFIVNTAGTVTWLDDLNWTGKEKWSTQNETVFKINDVIEGYSKRVDNLVFYVVFRAGHSVPADNLLAMNEILRKEILDDL
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MNRKILYSKTTDSYSEKVLIGEWFNRRHNVKPPLPQNHDFLTVYRESFTPKPYSKWDTALMWDHLMKNEDSNFISQNECYESTNFFDNYCSTNDLAYNYFPKCVKKPIARTWRMKKGWHEPIDEFLPSFGNLTSFGLVKQKKSQWECEKNFGLFTSYEADFRAPRPEDYKFDKFLFPKVNCVRLKMRGKNSVSQSRLVFITPSTYSNKVLIGPWVYDRLNAQYSPPEHKDHVTTYRDHFQPKQNSGSDLTAVWDQKLKSEDSNFIPQTGRSDFPNYFDNFSSIYDLSFNHFPKCLDGRLARKRQRNGHCIPLEEYLPTFGNMTQFGLVESKQEQWKCETQDPRRNKVTHYSDHYAAPELSAYKFKRFAIPLANSSIMDATNLTTMALNLRNRPTFKVVPPQDLVPVPRPPHLNPITWECIPEKPKVSKKCI
The following text describes a protein:
Function:
Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKKVKIGKQRRDKYYKLAKEAGYRSRAAFKLVQLNKRFEFLEKSRATVDLCAAPGGWMQVASQFMPVSSLIVGVDLAPIKPIKNCIALQGDITTNETRAAIKKELKTWSADCVLHDGAPNVGLNWVHDAFQQNCLTLSALKLATQILRKGGTFVTKVFRSNDYSCLIRVFEKLFKRVHVWKPAASRLESAEIFVVCEVYQKPEKVGAEYLDPKKVFANPDGSEGTKPNPQNMLIGKQKKAKAEGYDTNSLAIHSKVNASDFIKSSGYLDILGEANVILLDDPKWKNHEKTTEEVVEYMKDVKVLGPRELRVLLRWRKSMLETLEAERKAVEGEAQDVEIEEDLTEEQIEDRAMAEIDELIAKASEDEKAALKKKKKKMLKAKARVLKRRELKMIIDGDEGPQAEDQEVFQLKKIRKAKELAEITKETQAPDFENVEGKGRRKSSLKIPEIPAENLAKIPISCTFSDSDDEEGLGDGEWETHEQEVGGEDSDEDENELIHTVNSGLSKKEKKNVRTESWFEKEEIAGLISDEDDDDEMNAIEKHIGKKKKETKKYENTVSFDDGNKKKKKGKNGADDDGFNTKDGEDVEMASDSESDAEMDDAAKEKLSRFDAQIDLDDDEEERYEDEGTRATKRKADKKIIGEDMKPVEKKRRLTPEQLAIGEQMIYSSKSARELEENAWNRYANNDEDLPDWFVEDEKKHYFKQTPVTKEQVALYRERMREFNARPSKKVAEARARKQKKMQRKLESAKKKAEGILENDQMEHSEKVREMKKVYANATRKEKKKVELVRMTKGKKGKTARPGGQYKLVDSRMKKDLRAAKAKEKTKGRGRGRGGGAKKAGGGRGGGRGGRGGRR
The following text describes a protein:
Function:
(Microbial infection) Susceptibility host factor required for viral infection by recruiting viral RNAs to the host ribosomal complex via an interaction with viral genome-linked protein (VPg).
Sequence:
MVVEDAQKSAITEDQNPSRVANDNNDDEDLEEGEIPDDGDDGASATSKPPSALVRNPHPLENSWTFWFDNPSAKSKQAAWGSSIRPIYTFATVEEFWSIYNNIHHPSKLGVGADFHCFKHKIEPKWEDPICANGGKWTMTFQRGKSDTSWLYTLLAMIGEQFDHGDEICGAVVNVRSRQEKIAIWTKNASNEAAQVTFLFIQLVLVCFFFSLCLLLCCRWEGVREIYLASSIML
The following text describes a protein:
Function:
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.
Subcellular Localization:
Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction.
Sequence:
MSEPGKGDDCLELESSMAESRLRAPDLGVSRCLGKCQKNSPGARKHPFSGKSFYLDLPAGKNLQFLTGAIQQLGGVIEGFLSKEVSYIVSSRREVKAESSGKSHRGCPSPSPSEVRVETSAMVDPKGSHPRPSRKPVDSVPLSRGKELLQKAIRNQGSISGGGSGGSSSLLTNARSWGVRILHVDEMMMHVQQLSLASLCVKKQQPKKPEGTCPAAESRTRKVARLKAPFLKIEDESRKFRPFHHQFKSFPEISFLGPKDASPFEAPTTLGSMHHTRESKDGEPSPRSAAHTMPRRKKGYCECCQEAFEELHVHLQSAQHRSFALEAHLYAEVDRIIAQLSHSFADIPFQAGLPRWSGSPASDCDPLCPETLHPHQPSHPRAASPRIRKEDSCQASVTQGRAAGQQRWTESLDGVMGPPASHTCVSATTLLPALPKGSREQGCLCPCPASFTQSHLVTSLALLPGEWSPAEDMPLHPSQENSFAPADIPVKGPLLFPEARPWLMSARCWVRPFPFVTWGCLIPHDTTPLHEEVSPCPCLRLGYLYLLLTQSLWCRVRVPSLSTAGPIPRTSHPCTLAFPSYLNDHDLGHLCQAKPQGWNTPQPFLHCGFLAVDSG
The following text describes a protein:
Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite.
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTHHGASPAPQPKKSVNGESGSRNWRLGVESKAGGGLCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
The following text describes a protein:
Function:
FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MPLTKQLSVAIIDSNPALMNNFHIKKEDPPDPRVSTVTPATISFFKDMGAWEFVQQHRHAYFDKMQVWDYTGLGYTRYNARDVDADVLGCVVENKVLHKSLLSCIQNTDFQKTIHSSRLSSITFPAMSSVTSSSGTSSSASGSSAKLELDNGNSMYAKLVVGADGSKSSVRELARIQTTGWKYSQSAIICTVEHAVENFCAWQRFLPNGPIALLPIGEKFSNIVWSMDPKEAVDRNSMSEEDFVKAVNLALDHGYGPHPRSKSFEGGNVFSWLKADSTSSTHEGFEVPPKVTKLASHRMAFPLSLMHANSYASKRLVLIGDAAHTVHPLAGQGVNMGFADALCLSKVIAEGVAVGSDIGEITLLQRYESERKAANITMMAILDGFQKAYSIDFMPINVLRALAFNGAQYISPLKRKIISYASGNKLLPLFT
The following text describes a protein:
Function:
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.
Sequence:
MSGRRDNLIVGLDIGTTKICAIVGNVTEDGIDIVGIGTSPSRGMRKGVVINIESTVESIKKAVSEAELMAGCDIRSVYAGIAGGHIKGINSQGVIAIKNREVSSEDVKRVIDAAKAIAIPMDREVIHILPQEFIIDDQDGIREPLGMSGVRLEARVHIVTGAVASAQNIIKACNRAGLDVADIVLEQLASSESVLSADEKELGVALIDIGGGTTDIAIFVDGAIKHTAVLSLGGNHLTNDIAVGLRTPMAEAEKIKQKYGCCMASMVGKDETIEVPSVGGRKPRVLSRQLLAEILEPRVEEIFTLVNREIVKSGFEDLIASGIVITGGTTILEGMPELAEQVFNLPVRRGLPQQIGGLTDVVNSPVYATGVGLVVYGSKNVGIREFPTAQTDENMFRRVTRRMKEWFGEFF
The following text describes a protein:
Function:
Regulatory subunit of the dimeric uba-3-ula-1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-rfl-1 (uba-3) thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of ubc-12. Required for rfl-1 (uba-3) nuclear localization during early embryonic development.
Sequence:
MLPFDPSTRYDRQVRLWGEEGQASIGSTSACVLGSDSLATEILKSLVLAGVQSFYVVDDAKVEQADIGQNFFLHADDIGRSRAEATLEKLTELNPSVSGSASSQPPTALAMEDVEKLTTFSVVVAANQNEEIDTTFAKVLYNIRVPFICIKTFGLIGTIRICIKEHTIANSHEENPRPDLRLDAPFSKLIEMINETNLDEMTLEQLRHTPYILLHFKALEVFRKQRNDPEAFPSTTAERKELQAILMSFRRSSEESGTKDSENFDEAKAAVIRAFQRTTIGSSVKSILSSPQCSTSTRPFWLICEALRRFVTENNNLLPLRGTLPDMTSDSSRYTRLATLFHEKALSDAQEVLRLTREVEKERGVGDVISDDVCYRFCKNADRIRVQYGDVLDYNEETKAIVEKIRESNIDEETRNQKVDEATWMLLMRAVGRFQKEKGRYPGTNGVPVSIDAQDLKKRVEVLIREALKDEQDFTSISNKVTDTAIAEICRFGAAELHVISSYVGGIAAQEIIKLATNQYVPIDNTFIFDGHTQESATFKF
The following text describes a protein:
Function:
Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
Sequence:
MKKIHSRIRTFIAVPLFPAERDQLQTAIKPLIKQWTHLRWLPPENWHLTLRFLGDVTPEALEILRQATAKEAKETIKFKININKIDTFPPEKLRLLVAYIERQEHLSQLFFNLDQAAEKAGLAREERLFLPHITLAKSRRPIRHFDPLDCDLSIHAEELVIFESRPTNDGSQYVPLYKFQFSLH
The following text describes a protein:
Function:
Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization. Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MAKPVNVNQSKWTVPVLLKECEIYCPSTCVAFGPILSDNDSKLIIAHGGHRGVNMKLKVFQQLEQLSESSLADMPTALVHFINDLSSIPSIAVAAGPSLLIYKNLKPFYKFTVPSSAINPTESEAWKAVVNKKINGDTLLTVLKRLEDDVAFSKLTPISQTYLRADKETQVVLVEHYGTKIANSATITCIAKLTKSTAEPLDILVIGTEHCEIFLIDSQAFTILETIKIGSVPVNICAYGTYDVDYRLFVQTRASLIFCMKRGEADYQPIVISQSMITSMVLVNKMIVYTTVENLIHFASFRGKKMNTVKCPSKIKMLEPFIYPLKQLAAVIAVFDKEIRMYNEHYLLDTVQYEKPLAWVKYGCYGREDSTLVVAFKDGSIAIQIFRRKANFDTKLDYNQVPQAHALKLQIPKKTKVFIDLTQREVQLGNRIHKVYQKNLFDVKYRLAASYLELTSSASATVSTTTVLPVEISVDIHGFGPTFRMTIHLLSSSKQNLYDMHLSIISDPELYDFDTPLIPVHLLASGQSYSFTTLLYCKDPEKAANCDVRALLVHAKRATPIVTAVIKMPFSEFPLD
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
Sequence:
MSLTQIRKQELMTEYQAHETDTGSADLQVAFLTERITQLTGHLKANPKDHASRRGLLKMIGRRKRLLSFINAREPERYQALIKRLGIRR
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins (By similarity). It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Modulates the uptake of MRP substrates into the vacuole; reduces metolachlor-GS (MOC-GS) and enhances 17-beta-estradiol 17-(beta-D-glucuronide) (E(2)17betaG) uptake. Regulates cell elongation and orientation. Functions as a positive regulator of PGP1-mediated auxin transport. Confers drug modulation of PGP1 efflux activity as interaction with NPA or flavonol quercetin prevents its physical and functional interaction with PGP1. Required for the proper localization of auxin-related ABCB transporters. Plays a role in brassinosteroid (BR) signaling pathway. Required for seed development by promoting stamen elongation and, to a lesser extent, anther dehiscence and pollen maturation, probably as a chaperone helping ABCB1 and ABCB19 auxin transporters localization and activation. Involved in auxin signaling in nectaries to promote starch accumulation to attract visiting pollinators.
Subcellular Localization:
Cell membrane; Single-pass type IV membrane protein. Vacuole membrane; Single-pass type IV membrane protein. Endoplasmic reticulum. Note=Localized on the endothecium and middle layer cells plasma membrane.
Sequence:
MDESLEHQTQTHDQESEIVTEGSAVVHSEPSQEGNVPPKVDSEAEVLDEKVSKQIIKEGHGSKPSKYSTCFLHYRAWTKNSQHKFEDTWHEQQPIELVLGKEKKELAGLAIGVASMKSGERALVHVGWELAYGKEGNFSFPNVPPMADLLYEVEVIGFDETKEGKARSDMTVEERIGAADRRKMDGNSLFKEEKLEEAMQQYEMAIAYMGDDFMFQLYGKYQDMALAVKNPCHLNIAACLIKLKRYDEAIGHCNIVLTEEEKNPKALFRRGKAKAELGQMDSARDDFRKAQKYAPDDKAIRRELRALAEQEKALYQKQKEMYKGIFKGKDEGGAKSKSLFWLIVLWQWFVSLFSRIFRRHRVKAD
The following text describes a protein:
Function:
Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Miscellaneous:
MISCELLANEOUS: S.pombe appears to be critically dependent on the mus81-eme1 endonuclease for the resolution of meiotic crossovers. This may be due to the absence of an alternate pathway for crossover resolution such as the MSH4-MSH5 pathway which exists in S.cerevisiae and other eukaryotes.
Subcellular Localization:
Nucleus.
Sequence:
MDCGNPLFLQWIQEWMEESTRRFPKSYQTWRKAYDSMKSCPITFHRPSQALALKGIGPTICAKLEKKWNAYCLENNIPISTHNEQNDSHVNANKSSSETSSEKPRSVKKPTTRKRKVYVPSYRSGAYSILCALYMLNKHEFATKPQIVTMAQPYCDSSFGSATDRNMRYTAWSAMKTLITKNLVYQTGHPSKYCLTDDGEEVCIRLAKVDDSFQRKHTVSNFSVSKSDDHDSSLCQPPNFVTSINKAGSSSDHGGELHVTYCPVDHNEVSDGVETDIDVDQVDSLTGIHDHHIINNEQLIDLTEQEKKQPNESNLSNLKIETVLFSNCTVFLLIDTREIRSPLDRNLIIDKLTNDFGVNCQVRSLELGDALWVARDMESGQEVVLDFVVERKRYDDLVASIKDGRFHEQKARLKKSGIRSVTYILEESSYDESFTESIRTAVSNTQVDQLFHVRHTRSLEHSVSLLAEMTKQINLFYEKRKTLAVIPDLSIEAKTYESLREQLLKIDPSTPYHISYHAFSSVLSKSSTLTVGDIFIRMLMTIKGISASKAIEIQKKYPTFMHLFEAYEKSSSSQERNLLLNKTCQGYGFQTIGPALSAKVASVFFPES
The following text describes a protein:
Function:
Probable transcription factor (By similarity). Involved in responses to oxidative stress.
Subcellular Localization:
Nucleus.
Sequence:
MSSKRTSPNGKQRLLNFLRGLLEDDSHSDLITWSNKDTLEFQMLKPHKVAELWGAATGNPGMNYDKMSRGLRYFYTNNTLKKVKGKDSRYCFLDTPLLAPFPDFFPKANEPMRRVPLFSIENLLASSEETTSNFSLQSSPSSSSNSSSARTMSATSSPTSSLEDVINPPVLIDPFQMQMAHITQTFLATQLPALQAFPMQLQLQFLKTLLPTLFPNNN
The following text describes a protein:
Function:
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Chromosome. Chromosome, telomere. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex.
Sequence:
MAEVMDLGKDPNGPTHSSTLFVREDGSAMSFYVRPSSAKRRLSTLILHGGGILCRVQKPGAVLLAQPGEALAEASGDFISTQYILDCVERNEKLELEAYRLGLTEQASDPKPGASAEGSTEPEPQPLTGRIAYTDADDVAILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSLKDRYLKHLQGQEHKYLLGNAPVSPSSQKLKRKAEQDPEAADSGEPQNKRTPDLPEEECVKGETKENGEADNKLFEEATPELGEAVVDESPDFEIHITMCDGDPPTPEEDSETQPDEEEEEPKVSTQEVGTAIKIIRQLMEKFNLDLSTVTQALLKNSGELEATSSFLESGRRPDGFPIWCRQDDLDLQKDDDDTRNALVKKYGAQNVARRIEFRKK
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.
Sequence:
MTDRETNSYGKLLIVGLACVDIVNVAAVYPTEDTDQKLLDQQVNRGGNATNTSVVLSQLGSPVEWFGTLATDNLADVITEDLEKYGVICDNVRQYDNCVTPLSCVIVNASSGSRTILHKNKTLPELDPKDFEKLDLGKYSWIHFEGRNQVNVEKMISMIDDYNERRKDSKPITVSVEAEKTRNITHSFLQKAEFVFISKDYSMAMGYNSAEECLNGVREKKLLKIGAKAICAWGEKGAWGLEESGRIVHSPTYPPIKVVDTLGAGDTFNAGVLHALNRGRTLEEALRLGCQVAGQKVGRSGFRIDTASLDLL
The following text describes a protein:
Function:
Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
Miscellaneous:
MISCELLANEOUS: Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation; MISCELLANEOUS: Subject to X inactivation.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Enriched in transcriptionally active regions of chromatin in neurons.
Sequence:
MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLADMRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIESGYGEAPPPTESLEALPTPEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDERESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRLKRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVQDLRHISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDASHSFFSWFSNHSLPEADRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCEVVIMEDAPDYYAVEDIFSEISDIDETIHDIKISDFMETTDYFETTDNEITDINENICDSENPDHNEVPNNETTDNNESADDHETTDNNESADDNNENPEDNNKNTDDNEENPNNNENTYGNNFFKGGFWGSHGNNQDSSDSDNEADEASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDDRDIEYYEKVIEDFDKDQADYEDVIEIISDESVEEEGIEEGIQQDEDIYEEGNYEEEGSEDVWEEGEDSDDSDLEDVLQVPNGWANPGKRGKTG
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane during regulated or polarized secretion. Involved in polarized cell growth and organ morphogenesis. During cytokinesis, involved in cell plate initiation, cell plate maturation and formation of new primary cell wall.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MQSPKPRRKAGPTTNGLDSAEKLDELLISSAICNGEDLGPFVRKTFGTGKPETLLHHLKLFSRSKESEIEEVCKAHYQDFIHAVDDLKSLLSDVESLKSALSDSNSKLQSVAAPLLSSLDSLVEAGTVSNNVDLAIGAVKHCVRVAEIASRANRHLQGGSFYMALKCVELIESELLEKTPSSTLKRMIEKRIPEIRGYVKRRVSKELGDWLVEIRVVCRNLGQLAIGEASSSRQREEEVRIKQKEAECVYALNEEDIDGDEYESSDDDAFDLTPLYRAYHIHQTLSLEDSFKQYYFDNRELQLKSDSQIAGFFIVEDRVLRTGGGLISKMEVEFLWDLAVTNMCAVLEDQFSRMQTANHLLLIKDYVSLLGVSLRRYGYTVDPLLEVLSKHRDKYHELLLSDCRTQMAEALSADKFEQMLMKKEYEYSMNVLSFQLQTSEIAPAFPYIAPFSTAVPDCCRIVRSFVEDSVSFMSHGGQLDFYDVVKKYLDRLLGEVLDEALLKLISSSVHVVSQAMQVAANMAVFERACDFFFRHAAQLSGVPLRMAERGRRHFPLTKSQNAAEETLSGLLKKKIDGFMILVENVNWTSDDVPQGGNEYMNEVIIYLETLVSTAQQILPAKVLKRVLRDVIAHISERIFGTLCGDLVKRLSMAAIKGLDMDVQLLDSFTEQLTSLLTEKEANEMKTAFVGIRQMINLLLSSHPEKFLNPVIRERSYHALDNRKVATVSEKLRDPSDSIFGTFGARGSRQNPKNKSLDTLIKRLRDVS
The following text describes a protein:
Function:
May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.
Subcellular Localization:
Cytoplasm.
Sequence:
MIGLTGVIVLLIAVTVDGRIGDSTSESSYCSETKECLLFDLVCAGSDYEVRHYDAAKWVTTEAESYVMEIAVSRAFRKLFKYITGENEAGAKIDMTGPVTIKVNGSSNMWQSSVYVLSFLLPSNYQSKPPRPTDPSVYFTDSPDMKVYVKSFGGWMFSLVSKYQTQSLKTALDNAQATYETDYHYNVGYNSPMKITNRHNEVWFIVKGEPVCPKSE
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP), and the reversible cleavage of pseudouridine 5'-phosphate to ribose 5-phosphate and uracil. Is involved in a pseudouridine degradation pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MLIVMNRGCRLVSRIPLGFRRLKRNPNPGLRNILCRRYSPLALSKEVTEALKNNVPVVALESTIITHGMPYPQNEELAIQVESKVRSMGAVPATIALLNGQCTIGLEQFQLSELAKSGETAYKVSRRDLSYVASQRLNGGTTVAATMILARAAGIDVFATGGIGGVHRGAENSMDISADLIELGRTRVAVVSAGVKSILDIGRTLEVLETQGVPVVTLGPPKSAFPAFFSRESKFQSPLSLETPQLIANMLFSNIQLGQECGTLVAIPTPHHCSIDYEKMEALIETCLQRSVQLGITGKNVTPWLLGELLRESKGKSLNTNIDLVLNNAEKASLIAKELAVLKEKSSFFPTNTGNTFETKPVKQDFFYGKVSDKGVSSSKKKITETTSKPAEVVCVGSVSIDSVLKLDNPLTSKFLGTSHPCHSEQAFGGVAHNMALASSLMGASTKLVSCVGTKSVPTSSIKEYLTKSSLQHTIVEKSNFTSCSYTAINDCNGNLLLAGADMAIMENLSYSEIKDDLNDAKYICFDGNISPSLMLDITTSKSSKQRVVFEPTSGPKTLKILKVLSVASIDFITPNKFELDVLFQAMKDGNFFENESWWQKLNSFGITSSFYNEIERFTKSTGIEEITENGILQKCFHLLPFIKNIIVKLGPNGALLISSEKLQGVNSNSASLFTPGNVTVKYYPVPKVIATPVNASGTGDTFIGTFTALLSKGWGMDDAIDTAQKAAGLTLQCNFSVNPEIKTLLK
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.
Sequence:
MAQTSSMKLLGARNMSCIVERMEWNNKMDLIAYGTEKGEVVIQRLNWQKIVTFPTPGEDVRVRSLSWQMDETLLAVGYSNGKVALLDAESGTIISGLIYEDDIKKVYFSKAINSQENLGTYTCNVKDKHRRFLPKLQPMTNIDPCLKTLDQKSFPKGSPCFLVVIMRSGKVHLLLLGALQAGSIDLTQHILHPHEFDVYDVRMNGDCNAIYALLRDGQELILLHFQNQVLQDCMAPMLELATHCAHILETKNYINDTQQCLTEAWETVQLEMDNKLTRYANSQPYGVISAHFLELHVFGFATFEVEEFLFETLSEKGFKKIANSVDLSLSNLQSLVFKQLNGAAINMFYFLNTIAGFGRMSHFFESLISPDVANEAMRACGGFVLKVHELQRTIDTLAYDMKLFHAWMIFTILRLSHQEIPDDLVLTEEENIAMADFICAMEPELDDRSDDEDELDSQSQTPPPARSKFNLERVGQYLDNAYLTQLYPRDPVQLWEEMVTDNECLSNCKLFVPHDVNLSLVQQRDKMFNAIDAVFHKPTESISGSFKVSSTVICNDLPPMEPGEDHRDRDLVTCTYYVNEASRTDMLACTISGQEAMILEFSRAGDECVRCTRITLEPGLFTTSVSEDFCYLRFVDLQFYNESSLSILAQSINAGPGMRPHSFFIQFSLTAALNYSTQHRMGPLVKLSEATVSQSIHDIADGAAFKGLDGFSDMLAVSGSRKVATVLSDRKRKMTIFEMEIEEEEDDTEMSQASFLDISKESVLAGVPDAEKQEA
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MSENRLGICSTCQKNASKYRCPRCDSRFCCLECNLEHKRLTKCSGERDPATFVPKSKLVNHLNSDFNFLSGVERLINRKENGSHQVSNRAERNRLQLKRSLERAGINIKFAPPSNKKRRLNRTHYDKKSHLIKWSIEWCLHESSTSKDLTDEASENTIITHSHPESEPLEKIFRKLVEENSEMNSQVSKANIHAPDDMQFMIKSRKSRSKGFIYKKIEPSNSLSSCLRNSFVFEVPTIHVFTSTTQVHTESSYETSSSEQSDDSSSSSSCISDSEESSSDDELNELSNEKKANSPTQNVDTSSKLSSVKFQNEDDEDRRKNSDGSEASYSLPPLFGSYFQKQGQY