lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential for recycling GMP and indirectly, cGMP. Essential for chloroplast differentiation at early stage of leaf development. May not be involved in the synthesis and maintenance of the organellar DNA during leaf development.
Subcellular Localization:
Plastid, chloroplast. Mitochondrion.
Sequence:
MLLTRRFSSALARSPLLPRSLPPPRAVPATPPAPRPPPRRLMSSSSSGWHHSSRPPPPPPSGADKDQLFRGLEAALGTTFSSEPLAPPPQPMILVISGPSGVGKDAVIQRLQEEREGMHFVVTATSRAKRPGEVDGKDYYFVTKEEFLTMIERKELLEYALVYGEYKGIPKQQIRDYMAKGYDIVLRVDIQGAATLREILGESAIFIFLVAESEEALVKRLIHRKTETSDMLLVRVATAREEVKRMNNFDYVVVNSEGNLEGAVKQVESIIDAEKAKVHKRTVNI
The following text describes a protein:
Function:
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAKLAPTCWTLAFLVTLCTTGAQFSIQITPLCKGDQHYEYAGQCCTKCEPGKYMAAKCTATSETVCQPCGPNEYIDIWNEEEKCLLHKICDHGRALIEVNPGNSTSQRQCACTAGYHWNEDCDCCRRNRKCPQGSGVKHPIQQNKDTVCTPCPTGYFSNVYSATDACKMWTNCTALGTEEKMPGNSWSDAVCRQHLKPHEQDDSNTLLYIVIASFFLVALVGIFLLVRYYHKKGKTLTDLQYWAHVVCRQIKRTKDSPCDTFVNGNVACPEGPLLLKDMYSFSEDVFYPQGHNVNGEGVPDAIHYESGEDFPTQSLITMSEDDHFRQVPMEDEYTDRMSHGPHYLPLLSQAESKPISCFSEPLEMGENDSLSQCFMGTENVLEFPYCCCSDASCGTDTVQPSSHKCLPTSCYHSACRDADMQDISDAFLKSGETCGCTACKASCRESASKHFCTGNSLEDSSPSPLGTYGLDSPSLSHTDSASDSGVRSDPFDGNGTKQQNAKRIPESNCNTSDAPAASGNVTGNGNSTFISSGQVMNFKGEIIVVYVSQNSQEGSMSPGSSDDSLGSPVQEENLNRCETFAGNAHQYKEKCAEMNLPHSMSSSEPASTVGGFKRTSGPIVQEENLKGQDNKHLYNEASWPVQEEGKSGQFLKQALN
The following text describes a protein:
Function:
Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Associated with pericentric heterochromatin.
Sequence:
MGSNRLTARELCENDDLATSLVLDPYLGFRTHKMNVSAMPTIRRQHHLREALQTFCKKKDLEAAYQSLTAGGWARHYFHSRTRQQESLLKTHIFRYLRMFLPESGFMILSCSRYSLEMNGAKVVSTKSWSKNEKIELLVGCIAELSKADETLLRFGDNDFSVMYSTRKKCAQLWLGPAAFINHDCRPNCKFVPTEGNTACVKVLREIKTGEEITCFYGDSFFGEKNEMCECCTCERKGDGAFKQQNTEQTVSTSLEKYQLRETDGRLKRLSESACKPSPQVTTKKKGSKLRLSLRLKRIPASRRKGAFYRRVKTFASSRYFYKSHLMKHIPLKPVKIALPRGTVLRDVRIILHNCKKCNQASRPKSQHERQCCKLGKEPLVSLRREDLSPERLKFRLSCPGGSCPPIIQTANVGCNAKDCSQTEAGKSNLEQITTAELCEHLSFSPVPSHNEDDNSFYEPEIPGSLLGPESPSSEPLSNNLNLECNSPEPIVINTVYPHYNGGVTSDSHPHALKQFGITHYIQVDLRKDVTLEPGRSQPDKSSLEAEKKQIPNNKHSQHPVISDDHLVANLNAETQSNAVSPPTNTPICEALNGSLEHKVFSLRSRPVSFRPRKTSDNKITLFKRRRSSVKQGVRCVKLNGHVKLTGQLVPSKLHPPPGAGANHLTDAMHSDPKLLLKPYVELGLNNNLKRQSLTGLPPSTVLTGDAFNILHSPPASKQSTEGATKNVAFNPFTPSKRLRLVVSHGSIALDMASTSSEETS
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Sequence:
MSVTLHTTHGDLKVELFCEAVPKTAENFIALCAAGAYNDTPFHRLIPGFMIQGGDISLGPAANSQGTTPMLPFDDIPKGGTSIYHPSALNQEIHLPALRHNTRGILSMASRPVKNQTAPGSQGATGPTINGSQFFITFAAAPHLDGSSTVFGKVLNLTAEDEGGDVLSKLEKANVKTDKKGKVVQPKENEETEYETLRINRVTIHANPFAT
The following text describes a protein:
Function:
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
Sequence:
MTLSKMKVDYTLYLVTDSGMVPESSSFLKQVEDSINSGATIVQLREKSLSTLEFIKRAEQVHKLTQKQGIPLIINDRVDVALAVNAEGVHVGQDDMPAAIARKLIGDDKILGVTCSNVTEVQEVVEQGIADYVGLGTVYKTNTKKDVTDPEGTGPSGIRRMLRVLQKHNSKSGAKKIQSVAIGGINHSNVRNVMFQCAVPGEKINGVAVVSCIMANENAAEATLSLSQLISSAPYGYEPYEESQYLDDYQHSLKQLSSSSPMIHHITNNVVKNFSANVTLAIGASPIMSEFDEEFNELASTPNTALVLNLGTPSKEMMKIFKNSIIAHQSRNPIVFDPVGCGASKGRLECCRQLLDTGYFAVIKGNVGEISALRKLTSSYRESQSKSYMRGVDSISNLTEEEIIEIGKDVSIEFKAVVVITGPTNYIIEGEDKVVKVEGGNKLMGSITGSGCALGSTIAAFVSSQARSPQGPNNFYAAVHAVKLYNKAGAAVSEKTPGKFMASFIDELYKLTHS
The following text describes a protein:
Function:
Catalyzes the synthesis of mevalonate. The specific precursor of all isoprenoid compounds present in plants.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDVRRRAVKPLDASKHISSGEPLRPRNQDSSVKASDALPLPLYLTNGLFFTMFFSVMYFLLHRWREKIRDGIPLHVLNFSELVAMFSLIASVIYLLGFFGIGFVQSFVSKGNNDSWDVEDETPEQFIDATVTSPPVRRNIPMKSVPVDENAAQIITPFSGEDDEVVIKSVVEGRIPSYSLESKLGDCKRAAFIRKEALQRTSGKSLDGLPLDGFDYESILGQCCEMPIGYIQIPVGIAGPLLLNGNEFSVPMATTEGCLVASTNRGCKAIYVSGGATSVLFRDGMTRAPVVRFGSAKRAAELKFFVEDTMNFETLSVVFNKSSRFARLQNIQCAIAGKNLYMRFSCSTGDAMGMNMVSKGVQNVLDYLQNEYPDMDIIGISGNYCSDKKPAAVNWIEGRGKSVVCEAIIKEEVVKKVLKTEVAALVELNMLKNLTGSAMAGALGGFNAHASNIVSAVYLATGQDPAQNIESSHCITMMEAVNDGKDLHISVTMPSIELQHSQYFLTFLHFFSVNSGDRKIFTMDVRRRAVKPLDASKHISSGEPLRPHNQDSSVKASDALPLPLYLTNGLFFTMFFSVMYFLLHRWREKIRNGIPLHVLNFSELVAIFSLIASVIYLLGFFGIGFVQSFVSKGNNDSWDVEDETPEQFIDTTVTSPPVRRNIPMKSVPVDEKDAQIITPFSLEDDEVIIKSVVEGRIPSYSLESKLGDCKRAAFIRKEALQRSSGKSLDGLPLDGFDYESILGQCCEMPIGYIQIPVGIAGPLLLNGNEFSVPMATTEGCLVASTNRGCKAIYVSGGATSVLFRDGMTRAPVVRFGSAKRAAELKFFVEDTMNFETLSVVFNKSSRFARLQNIQCAIAGKNLYMRFSCSTGDAMGMNMVSKGVQNVLDYLQNEYPDMDIIGISGNYCSDKKPAAVNWIEGRGKSVVCEAIIKEEVVKKVLKTEVAALVELNMLKNLTGSAMAGALGGFNAHASNIVSAVYLATGQDPAQNIESSHCITMMEAVNDGKDLHISVTMPSIEGATSVAAMRNASFEALS
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MGPLCAVCESPTAFTLHFGGRCCKACAAFFRRTIALDLKYECAADDPCEIHFKFPGMRLVCRECRLRKCYSAGMRSELVRSKRENFACTRRKDSRNNSDAAPNSNSPSTRQSSSPEEMDDWSFQMFEEKPKIEDLPLTPSISHPPLPTQLMPEESSRTSSFDGGYCSSYPSSSAATHPSPPGMLYSIENNSILQYYHSMETGLCSKRRIMYTNTGMDFILDTHANLQCPFTVNDLRPHDYRNFRGMLRHDFVMLFDYATRFPEFNSFTSHEKNMFYRQIVAVDFILSSAYYTAKLGQAHRQMVLTNGEYLNMDPLPMSGNEIDARRYFDCDEDFSKYRALMPMHIAIWEESIVPFSKLNVTFEEFCLLKALTVWQATYFKLTENGREKCRRQRNIIIGFLSKMCHSPGGGGEHRVGELLMSMNYLRESAQKLTTSYVMLTVFNVLNCDSMLHEMLNFQY
The following text describes a protein:
Function:
Required for lysine biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli. Not active with meso-diaminopimelate, lysine or ornithine as substrates.
Miscellaneous:
MISCELLANEOUS: The expected covalent binding of pyridoxal phosphate by Lys-305 has not been observed in the 3D-structure.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MSSTHQLVSSMISSSSSTFLAPSNFNLRTRNACLPMAKRVNTCKCVATPQEKIEYKTKVSRNSNMSKLQAGYLFPEIARRRSAHLLKYPDAQVISLGIGDTTEPIPEVITSAMAKKAHELSTIEGYSGYGAEQGAKPLRAAIAKTFYGGLGIGDDDVFVSDGAKCDISRLQVMFGSNVTIAVQDPSYPAYVDSSVIMGQTGQFNTDVQKYGNIEYMRCTPENGFFPDLSTVGRTDIIFFCSPNNPTGAAATREQLTQLVEFAKKNGSIIVYDSAYAMYMSDDNPRSIFEIPGAEEVAMETASFSKYAGFTGVRLGWTVIPKKLLYSDGFPVAKDFNRIICTCFNGASNISQAGALACLTPEGLEAMHKVIGFYKENTNIIIDTFTSLGYDVYGGKNAPYVWVHFPNQSSWDVFAEILEKTHVVTTPGSGFGPGGEGFVRVSAFGHRENILEACRRFKQLYK
The following text describes a protein:
Function:
RNA-binding protein that acts as an associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs. M6a modification plays a role in the efficiency of mRNA splicing and is required for sex determination. In the WMM complex, may act by binding target RNAs and recruiting the WMM complex. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. Acts as a positive regulator of canonical Wg signaling during wing disk and eye development.
Subcellular Localization:
Nucleus.
Sequence:
MSSHRDGAGADRITIKIHNMKRSASRSPGPASRSSLSRNSRSMGRGYDNGSGVPGDSPERLSPERMRRRLDRSPSRYGSPHREPYMRGPPPAERPAGYKVLCVSALPPKAPDDFIEETLYREYKKFGDFSVRLAHDLDERVAYVCFRTPEDAREAKHHKPRLIIYDKMAIVEPVYKSTTRPEYRPRGHSMSPPDYERYHYSRSPMGQGVPLDHRRPPIDPYDRYGPPHMHPHAVHPRDYRPLHHDYPHPPRGPPLHRGGHPHHLHGHAPPHQYAPMRPLAPRPHAPYEKPESKKDKFPNYLHHVQPEDDPLSTRTLFAGNLEVTIADDELRRIFGKYGVVDDIDIKRPPPGTGNAFAFVRYQNLDMAHRAKIELSGQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVTQLEREFDRFGAIKKIEYQKGEPYAYIQYETVEAATAAVKEMRGFPLGGPERRLRTDFAELPGATPAAPFKSSKPPYDESALEYRRPEYDPYYEESAAYAPRGGYSPYPPRGGYRGRGGYRGRGRGMYHYHNDVHRPPHPGSLAGSSSSVPPPGGVEDEWRRPPGESYDRGARSSSREPGVERSRSRSPLKRARSPGSDSDTSTRRNDALASASTVPDVARKCSTVWTGALILKSSLFPAKFHLTDGDTDIVESLMRDEEGKHNLRITQRLRLDPPKLDDVQKRIASSSSHAIFMGLAGSTNDTNCDDASVQTRPLRNLVSYLKQKEAAGVISLLNKETEATGVLYAFPPCDFSTELLKRTCHSLTEEGLKEDHLVIVVVRGGTA
The following text describes a protein:
Function:
Inhibitor of tracheal branching that restricts branch budding by antagonizing the BNL-FGF pathway (BNL: branchless, an fgf inducer of branching). Acts as an antagonist of EGFR-mediated signaling in the eye (where it is important for cell determination) midline glia, chordotonal organs, wing and ovarian follicle cells.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The Cys-rich domain is responsible for the localization of the protein to the plasma membrane.
Sequence:
MDRRNGGDPLAPPRPPKLLPRVHRPRAPEPTLSGVDHNAGATASALASGASSAAPVAIHNNNSQQQLSISAAASNNNTISIIPASPDFDDYQIHHLTFLPQRPSSLSRNSSTASSTTATGISVSGSGSVSGSSSSFTRRRPPAPVPLNNSISNNNNNSINNNFLSHFQSAEPASNALGQPPASPVTLAQPRPESERLTNEYVDTPLQHATRSQHPAGQQDNGQTTTHHLLLLPQRNQHLHLQQHQQHLQQQQQQQQQQQQQQHLQHQQNQQHARLATTTQATSVGSDHTDGLLHSHLQNSTTKPPASKQPAPPRLGMGLGLGLGLGLNQPIITKQPTPATQKERMHALEELLQPGGAGGNGGPLVMAGDPSLLNPIVCPRCGRCRCEQCQSPRPLPQTWVCNKTCLCSAESVIDYASCLCCAKALFYHCARDNDLDCDDGNGTPCVDNPCSCGPYKRTQRWGWLGALSIFLPCLWFYWPMRGCMKLCEKCYGRFAGRGCRCQGIGGGGAGSGGGVGSIGSTSSMLPIVPLGVNGSGLGGGVSLSGGVTDGGLNQANGKAMDHGCSAARSILRKGDLTPEKRLLDSSPDY
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fumiclavanine C, a fungal ergot alkaloid. DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan. The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (By similarity). The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by EasD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde. EasA reduces chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline. EasG then catalyzes the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine. Hydrolysis of festuclavine by easM then leads to the formation of fumigaclavine B which is in turn acetylated by easN to fumigaclavine A. Finally, easL catalyzes the conversion of fumigaclavine A into fumigaclavine C by attaching a dimethylallyl moiety to C-2 of the indole nucleus.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MDFLQRILGILSSEDVAPALFASSISVLFLILSYQVLYPPSKYSAFPTINGTRWLALSNRRILAEFVTDAQGLMRNGLEKYDIFRIISSIGPMTILHPKYTDEIHNDRQLNFMAVLAKEMFPNYPGFDLFREGTDGSTVLQDAVKFGSSRCLGKSTQLLSDETSTLLQKLWGDEPEWHEVTAKSSVHDIIAHLSALLFYGPELCSHKEWLEVTDEYASVGFLAARQLRLWPPILRPIAQWFLPACRRLRYLASRTRGLIEPVIAARQKEKAICYSHGRQPPVYDDAIEWTERAAKGRPYDAAMSPLLFSINALHTTTDLLTQVILDLSTQPDLIVALRQEILSVKPQQNGWKNASLNQLLLMDSAIKESQRLKPTESILMRRYAMDDLTLADGNKIPKGTVLGIPIFGMRDPKIYVDPDMYDGYRFQKMRDKPGFENKCQLVSTSPWHLGFGHGIHACPGRFLAAVQVKIILCYIVAKYDFKLAGGAPPKVQSVGIELISDTEARLAVRRRQEMVIGLE
The following text describes a protein:
Function:
May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
Subcellular Localization:
Nucleus.
Sequence:
MTTAQFYCQYCTASLLGKKYVLKDDSLFCVTCYDRVFSNYCEECKKPIESDSKDLCYKDRHWHEGCFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEFKGNYWHETCFVCENCRQPIGTKPLISKESGNFCVPCFEKEFAHYCNFCKKVITSGGITFCDQLWHKECFLCSGCRKDLCEEQFMSRDDYPFCVDCYNHLYANKCVACSKPISGLTGAKFICFQDSQWHSECFNCGKCSVSLVGKGFLTQNKEIFCQKCGSGMDSDI
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MASSSSTKKFTMKSSDGETFEIEEVVFQSIKNLTDGAANDTEILVPHIPGKFLAKVIEYCKKHVEAASSDEKLFDDELNKWDTEFVKVDNVTIFNLIWAASYLNIKSLLDLSMKALADMIKDKKPEEISKIFNIVNAYRPKEDEEVRCENQCTFEN
The following text describes a protein:
Function:
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.
Subcellular Localization:
Cytoplasm.
Sequence:
DVTHSHNSCGILLHNITRNVFVFVRQFRPAVLMHDVGMKLLSVNGETCVNIEHDTLQRGFTVELCAGIIDKKDKSVEETAALEVLEECGYRINFKDLEPISSTRLPLNLGTLQSMFYIKVTDDMKVDGYGGGNEEEGELIQVVEVKVEDVLKSVFDDQLPRPVGWTFAIVWFCYTK
The following text describes a protein:
Function:
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Sequence:
MKTARRRSRELAVQAVYQSLINRTAAPEIAKNIREMSDFAKADEELFNKLFFGTQTNAAEYIRQIRPLLDRDEKDLNPIERAVLLTACHELSAMPETPYPVIINEAIEVTKTFGGTDGHKFVNGILDKLAAQIRPDEPKRR
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSTRKQYACDLACRLVQDQYGDAVGKVFKLLVSKGQLQLGDIVRGTSMNPNIVKQALLILIQQNCINSYLQPGEETLRGPRPSFYLYEANTDRVLQIIRHPRFLLHIKDEAGEVAEAVIAQLLQEGRLRMDQVLGSVAARLGKALDKETRDSISNTFISLVQAHYVERSPPCSLPPPAVRPHPNSVRTRKAKSAASNTEGYAADQAAALKSFEELSFEKQRFKVPAELALEMFMSDVPAAAAAAAADGAANGGGSGEGSGDEEGDERAASPDAKMEDADGAGESAGGSGAGGSGAGGGRGRKKRAAPDDDDELAIKITAPAKKAKMRAGTARPDVSASPGSQSPTRTTGGGAGAGRAASPGSPVAEPAVVLWRVNNDEFNRRFRHQAIVGLVREKFDEDAAGVVSAMLAAGRPFESSVKEERSVQLSEDEVEATAHKLANAGIIPSMAGVSVSGVLRTLANDGFEMFTHVGTGPQGSASYVVNSQRVIDLIMLKQTEAVVKARFDVAGLRVFRLLALRGQLEQKQIADLAMLPAKDTRELLYLMLQGGFVMLQDIPKTADRAPSRTFYTWRVNMTSLSDSTAAQLYRSAGRVWQRLQFETEKEKDLVALIESAKETRTVNFNLTTAQRQAVARLKRVNEVMETSLAHLDQMIAVFNDF
The following text describes a protein:
Function:
A murein DD-endopeptidase with specificity for D-Ala-meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH. Partially suppresses an mepS disruption mutant.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Note=Uniform peripheral location, with partial enrichment at cell poles.
Sequence:
MQQIARSVALAFNNLPRPHRVMLGSLTVLTLAVAVWRPYVYHRDATPIVKTIELEQNEIRSLLPEASEPIDQAAQEDEAIPQDELDDKIAGEAGVHEYVVSTGDTLSSILNQYGIDMGDITQLAAADKELRNLKIGQQLSWTLTADGELQRLTWEVSRRETRTYDRTAANGFKMTSEMQQGEWVNNLLKGTVGGSFVASARNAGLTSAEVSAVIKAMQWQMDFRKLKKGDEFAVLMSREMLDGKREQSQLLGVRLRSEGKDYYAIRAEDGKFYDRNGTGLAKGFLRFPTAKQFRISSNFNPRRTNPVTGRVAPHRGVDFAMPQGTPVLSVGDGEVVVAKRSGAAGYYVAIRHGRSYTTRYMHLRKILVKPGQKVKRGDRIALSGNTGRSTGPHLHYEVWINQQAVNPLTAKLPRTEGLTGSDRREFLAQAKEIVPQLRFD
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSTNIDNRVPIEKTIEVIVKNDKGEEVKVIKRYQEYQITVKRNRKVDERKKWKKFGECDNKTGLENTAYGDEQFLVLTRGAEVKEEEKDVVKCRICKKNHFTTKCPYKDALELTTQPQKSEKEEKPISNKYIAPNLRGGYTGSAPSGSDVPSIMVSNLSQNATEKDLYELFGQFGPVSRVSIPKSMEGSSKGFAYVTYNHLDSAEKALKQLNGHRYDYLVLSLEFAKKKSLN
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSRKPADVASKERNEYIPAFISKKPFYIDDDDTANDYLEHQRLHKQTTDQSKWYERGKRAGPAATKYRKGACENCGAMTHKAKECLSRPRKHGAKWTGKDIQADEVIQNVDLGWDAKRDRWNGYDAAEYRQVVEEYEELERLKRQAKLTKGETQTTNDGLDDEAPEQEARYAEESDMGRQQSTATRNLRIREDTAKYLLNLDLDSAKYDPKTRRMVDMGAAEDQAAALVAEENFVRSSGDAAEFERAQRYAWEAQERGTQKIHLQANPTSGEITRKKELAESEAKRDAHRKALLEKYGGEQHLKHTPLLETMVVENERFVEYDETGAIKGAPKKATKSKYPEDILTNNHKSVWGSWWHNFQWGYACCFSTVKNSYCTGEEGKRAFEEARNMLLLPGDETEQPSLAVESASRQEEPSAESHNQQRDSKKRTLMEVQSGITEEELESYKRSRLAADDPMAAFIEKDDS
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Required for the localization of cnp1 to the centromere.
Subcellular Localization:
Nucleus. Chromosome, centromere.
Sequence:
MESFENKGFLDIEEGIQWIKKNSENLSSSKKTILARLQQFHKLCSEVGLNQHSISSLLDVILSKKTHFDKNHVQLLIKCLYPNELISQTIAIRIISSLDPHGLRCSYAIQAKLLNWLIHVYEFLDGNNLLCRYYGVLFHFLDFLTLRPYISNLLVLLTKHYHVKSFRIHQLLALYQKPGNTADPYLLALILTYKQHFPDVIVGSYTYRKHGSVRLDSEWIAATKAILNRQSEDVPLETWSSEKRKRQSSLIPDLITMKNTSSSYSLEELTSVQQMGLVYEKIVFPSRIAAVLKSKLFLIFLFLKNKNVYYSRLDEWLHITLNYGLALRSGSNNQEEEVLHLLYKYLLFSPKFPKSLLQYVITFFSKPNITEENYNLLTLLVTHIPITTDSSYFNSLLKEFEQFILQKNAEFCSKHLNILWLWLFRMLNLRIASMGNNHTLLEKCLLITNHATFLVSHFSWDVSLAYQLSRLFQLYYKILTKIRKQIEPNIPPKELIYVLFFQPSAFYINSMVGLLLLTKNYQERLMDSRIDAISKFTHSYLKSLSEIILLKEKRAILSFLQLWEPFKSDYSQFLPIATRIANDHPYAQRVFSLTCAPQFFSYINGYQIYLQQTNPATGSIPLKPIQEETFGAFQSNLHLSDSWEDFQKNFIIYLKKKGYLAISDFLLSTLNR
The following text describes a protein:
Function:
Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.
Subcellular Localization:
Mitochondrion.
Sequence:
XPGFVFAPCPHELPCPQLTNLACSFSQAYHPIPFSWNKKPKEEKFSMVILARGSPEEAHRWPRITQPVLKRPRHVHCHLCCPDGHMQHAVLTARRHGSSWGDLLPVLTPSAFPPSTAQDPSES
The following text describes a protein:
Function:
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MGLGLLTLTPSSMSETKRKGRGRGKKHREGRKRERERAPELGDEAVPPKLKKMKSQTAQVGEKQSLKCEAAAGYPQPTYRWYKDGKELNRSKDIRIKYGNGKRNSRLQFNKVKLEDAGEYVCEAENILGKDTAKGRLNVNSVATTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGARCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEELQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLEQTESLTSDSQSGIMMSSVGTSKCNSPACIEARARREAACNIEDERRPAMPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISFRLAEQQPLLRHSPATAAAASAAPASDMQRSYDSYYPPRRGCSHDSMGSLPASPFRITEDDEYETTQECAPTLEPPKRTATGHRRWRKSRLNGHMAQRARAVRDSFSLSSASYSESDEELVAECTPFLSIHTSDMLGTDSPPLYQPVDSRTYYSLDRHSTQESRHSRITHPRGKQDSAPL
The following text describes a protein:
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.
Sequence:
MEEEVQQHSHCMNCVSRRCMTRPEPGVSCDLIGCPLVCGAVFHSCKADEHRLLCPFERVACLNRNFGCPFTLARNKVAEHLEMCPASVVCCTMEWNRWPVSYSDRKSYESLSRDVDEVAQLDMALALQDQRMLLESLKVATMMSKATDKISEPREQISVKSSVQEIPRTNGLVSVDEESYGALYQATVETTRSLAAALDILNSATRDIGMLNTSLHATANEMDEENNKESFQDKNLKDQDHLDEGEIGAVGGVDYSGTSQNAQAEQNGSSDLLCDLNPSSNGTSALCNGFPLEKMCIQVKGQDQNFHGDSTESNITNGDCVEADGTSEPSSSLVVPEQLREISPFSALPDSTFQQILMPDEDDEKDLCWKKVDLGDLKDVNGSPFSHAPSFKFLSNSWYIPKEDKAVDTSDLEVAEDPMGLQGIDLITAALLFCLGDSPGGRGISDSRMTDVYHVDFGTQTFSLPSAILATNTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLECVARYQPKQRSMFTFVCGQLFRRKEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSTQGAKIIHDRHLRSFGVQPCVSTVLEEPSRNCVLGLRSDHLSSLPFEVLQHIAGFLDGFSLCQLACVSRLMRDVCGSLLQSRGMVILQWGKKKYPEGNSSWQIKEKVWRFSTAFCSVNDWKFADILSMADHLKNCSYNVIEKREEAIPLPCMCVTRELTKEGRSLRSVLKPVL
The following text describes a protein:
Function:
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in position 34 of the tRNA(Asp), the wobble position of the QUC anticodon. Does not transfer glutamate to either tRNA(Glu) or tRNA(Gln). The incapacity of the glutamylated tRNA(Asp) to bind elongation factor Tu suggests that it is not involved in ribosomal protein biosynthesis.
Sequence:
MLPPYFLFKEMTDTQYIGRFAPSPSGELHFGSLIAALGSYLQARARQGRWLVRIEDIDPPREVPGAAETILRQLEHYGLHWDGDVLWQSQRHDAYREALAWLHEQGLSYYCTCTRARIQSIGGIYDGHCRVLHHGPDNAAVRIRQQHPVTQFTDQLRGIIHADEKLAREDFIIHRRDGLFAYNLAVVVDDHFQGVTEIVRGADLIEPTVRQISLYQLFGWKVPDYIHLPLALNPQGAKLSKQNHAPALPKGDPRPVLIAALQFLGQQAEAHWQDFSVEQILQSAVKNWRLTAVPESAIVNSTFSNASC
The following text describes a protein:
Function:
Sterol O-acyltransferase that catalyzes the formation of stery esters.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTSTPPANRHRPLPFEEDFLPKQHPKVAHLASDLAPDSLESSAITTPASEIMPSSELPSTPLDGRSTPESEGEPSVATSTVTTTISTTQGTGSSTVEFRHIGAKGLSHRVGKNGAIHLEPVAASSKARKKMRAVVSFRPRQSHFDRFNETSSRDQFRGFFTLFWVCLALFVLNTSYTSFASTGQVLSLTFATLFSKDAWMLALSDGVLIASLFICVPFAKVCRSGWVRYWPTAVVFQHLWQAALLGAVIKWARYREWPWVQSGFFVLHTLAMLMKIHSYMNVNGNMADTYHRMRRVEAMLEERVAEVEGSEAGRGEEQLRAAWATAVRHARQSGGFADLDASKDVARSLAQWSSLDTQRGSDSRRPRAGQSLNATNCGEDGESKLEFKHQHNEKVQESTMGQKRLSKQEHIELHKNLAEQEKSERSTAQSSHQQNGQNITNQPSPLGRKPSTSRHLFDSQHTIRDPHPLSSHPDTLISDLAREVEVLREDLLSARSPSEPSSTELIPQDPVMWPGNISYANFWDYLLVPTLVYELSYPRLKTIRPLYVLEKTLATFGTFLVIYVITEHWIMPFTPTADTPFLRTFLQLAVPMMINYLLIFYIMFECICNAFAELTRFADREFYLDWWNATSMDVFSRKWNKPVHSFLLRHVYASTIAAWGLSKSMAMFLTFLLSSLVHELVMAIVSGKIRFYLFAAQMVQLPLIFLSQVPFIKQNETLGNMIFWIGLMAGFPLLNIGYLVY
The following text describes a protein:
Function:
Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP.
Sequence:
MKNVLSIQSHVVYGFAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWTGMVIPQEQIREIVTGLDNIEKLQECDALLSGYLGSAEQVDQILFALEQIKLRNPNALYLCDPVMPHPKKICVVANGVREALIEKAIPVADIMTPNLHELRQLTEFPINTFDDVLKAVNALIAKGVKKVLVKHLGSAGKINDPDTFEIIMATPEGVWHLSRPLYQFNFEPVGVGDLIAGTFLANLLNGKSDVEAFEAMNNEVAGVMKTTFELGSYELQTIAARFEILNPSSNYKAEKVA
The following text describes a protein:
Function:
[Isoform 2]: Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane.
Subcellular Localization:
[Isoform 1]: Membrane; Single-pass membrane protein; [Isoform 2]: Secreted.
Sequence:
MAGQPAATGSPSADKDGMEPNVVARISQWADDHLRLVRNISTGMAIAGIMLLLRSIRLTSKFTSSSDIPVEFIRRNVKLRGRLRRITENGLEIEHIPITLPIIASLRKEPRGALLVKLAGVELAETGKAWLQKELKPSQLLWFQLLGKENSALFCYLLVSKGGYFSVNLNEEILRRGLGKTVLVKGLKYDSKIYWTVHRNLLKAELTALKKGEGIWKEDSEKESYLEKFKDSWREIWKKDSFLKTTGSDFSLKKESYYEKLKRTYEIWKDNMNNCSLILKFRELISRINFRRKG