lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.
Subcellular Localization:
Nucleus.
Sequence:
MNIHKHTHHHTHEFNTLPLAQFERTRDAGNTAITRPQEIAHFSYDDSHEFRLDDSSIRWYYPPDLGTDLNRGFETFRKHDDSKDEHLDSLLRALIEKEKVTNVKTEADVITWRGMMTKEDHQYKVKTRARQDARQRPQPGRPSGDAMSFWVYKGSKSEDGKSTEWIELKTTVTPRHRGDEQNFEKKLLKFWLQSFLLGVPHIIVGKRSPDGILQSIERINTAQIPGMVKKRGNNSWDGDMCINFANRFLEFIGDGVWKIRRREKSMAIEVFKTEEVEGHGGILSDEFVEWRNAFNRQTAHDSHVANNTVQMNGMNIAAGDAPESVLDDVL
The following text describes a protein:
Function:
Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 26 nm in diameter, and consisting of 89 capsid proteins dimers (178 capsid proteins). Involved in viral genome encapsidation through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome (By similarity); Acts as a translational repressor of viral replicase synthesis late in infection. This latter function is the result of capsid protein interaction with an RNA hairpin which contains the replicase ribosome-binding site.
Subcellular Localization:
Virion. Note=The shell is composed of 178 copies of the capsid protein and 1 copy of the maturation protein.
Sequence:
MSKTIVLSVGEATRTLTEIQSTADRQIFEEKVGPLVGRLRLTASLRQNGAKTAYRVNLKLDQADVVDCSTSVCGELPKVRYTQVWSHDVTIVANSTEASRKSLYDLTKSLVATSQVEDLVVNLVPLGR
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
Sequence:
MRVAATEQTQLPAVFLPVSTTSRESVSDDQSADNGSYVVVARRYRPRDFTQLVGQDHVARALQGAIETSRVGHAYLFTGARGVGKTSTARIFAKALNHPDGPTANPDSESDVAQAIDSGEDVDVIEIDGASNRGIDEIRSLRANVGVRPSRSRYKIYIIDEVHMLTGAAFNALLKTLEEPPEHVKFIFCTTDPEKIPITVLSRCQRFDFAPVESDKIVQRLREIVEAEDNTVEDEALELLARRAAGSMRDSQSLLEQVLSFSDGHLTADHVHTMLGTADDQRLHRLAEAMADRDASAALSQIDEAIAAGVDAGRLAEQMLGYFRDLMAVAVGCEASLMRYAAASMHGSLGELAGRWGLQTVLAIVGLVDETLVRIRHSVHARVLLEATVIQVCHLPDLQAISDLTAAASGAGGGKSAGEKKKRVAVASSSPSSAAMPTSAVPSSSTSPAAGSDAKVRVDSPAAPSGDHRAATSATASVAAGVPSGTPPVNSGSTAATSSQPAPQSQAVPSGGVATAVATPPQSEGAENSAAANESTTSTDGYPLISGDEATSSWSQVLQEMDPMTATLAKAAERVDSPEPGVLRMIFPGNSGLAFSRCQMPEHKEEILRTLSRVTGRRATLQFEATAVKKIEPVAAAKPKNKNRMQRMREIQANPLVQSCVELLGAEIVRVDTPRG
The following text describes a protein:
Function:
Involved in the presentation of foreign antigens to the immune system.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAVVGSGKRVPLPWDVLLQLLLVPCLATGSELHSLKFFSFAVSEPSPGVPEFGLHVYLDDHFLAQYDSEKQKLKFQNKRIENRVGHGYIEKQILQISLWQDWFQSQMQDIMSHYHHSGGSHTFQNVIGCEIQKDNSSKGIFFFGYDGEDYISYDLDKETWTTKDSVAKITEQKWNATEAHRKSELLDKCVQTFQDLVKYKKYILDLKERPSGLVTQHTGPNREMILKCWVFSFSSPNIVLSWLKDGEEMEQDTKHSKARPSGDGTYQKWASVEIPPGEKEKYICRVKHGELSAQFNQAWELEPDSLTIWVIAFCLVAVLFFTLVWIWNCVL
The following text describes a protein:
Function:
The glycine cleavage system catalyzes the degradation of glycine.
Subcellular Localization:
Mitochondrion.
Sequence:
MFSLARPTARPVAALARRALATSAVLAQLKKTPLHDFHVQHKAKMVPFAGYSMPLSYGETGQITAHKHVRSDAGLFDVSHMLQHNFTGPTAQEFLLTLCPSSLDSLKPFTSTLSVLLNEQGGIIDDTIITKHSDSAFYVVTNAGRSVEDKAHISQKLEEWNAAHKGREVKWETLEGWGLLALQGPKAKDVLQRVTDQDLNKVKFGSSVFADIKTMDGQTVKCHVARGGYTGEDGFEVSIPPEHTLALSNTIASHPDVMLIGLGARDSLRLEAGMCLYGHDLDESVSPVEGGLSWVIGKDRRAPDAQPSFPGKSRILEELANGPSRRRVGFEVIGSPAREGCKVLDALGEKEIGVITSGIPSPTLGTNIAMGYIANGSHKKGTAVKVEVRKKLRDAFVKPMPFVPTKYFK
The following text describes a protein:
Function:
Part of the ABC transporter complex HisPMQJ involved in histidine transport. Is also part of the ABC transporter complex HisPMQ-ArgT involved in lysine/arginine/ornithine transport. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLYGFSGVILQGALVTLELAISSVVLAVIIGLIGAGGKLSQNRLSGLIFEGYTTLIRGVPDLVLMLLIFYGLQIALNTVTEAMGVGQIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPSMMRYALPGIGNNWQVILKSTALVSLLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLFLERRYSVGVKRADL
The following text describes a protein:
Function:
Promotes double-strand break (DSB) end-joining and facilitates programmed recombination by controlling how DNA ends are joined in a spatially oriented manner during repair (By similarity). Also plays a role in DNA repair by restricting DNA end resection in double strand break (DSB) repair. Facilitates replication of complex DNA regions and regulates the maintenance of chromatin structure (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Mitochondrion. Chromosome, centromere. Note=Colocalizes with NEK6 in the centrosome. In response to DNA damage, translocates from the cytosol to mitochondria and nucleus in a reactive oxygen species (ROS)-dependent manner. Centromeric localization is facilitated by its interaction with PCNA.
Domain:
The atypical PIP-box motif mediates interaction with PCNA; The helicase C-terminal domaine drives nuclear localization and recruitment to damaged sites.
Sequence:
MDQSTPKPHAETNSKDIWHPGERCLAPSPDNEKLCEASIKSITVDENGKSFAVILYSNFQERRVPLKRLQEVKSVKDCSRNFIFDDEDLEKPYFPDRKFPSSAVPFQLSENGDSIPYTINRYLRDYQREGAQFLYGHFIQGRGCILGDDMGLGKTVQVISFLAAVLGKKGTREDIENNMPEFLLRNMKKDPPSTAKKMFLIVAPLSVLYNWKDELDTWGYFRVTILHGNKKDSELIRVKQRKCEIALTTYETLRLCLDELNSLEWSAVIVDEAHRIKNPKARVTEIMKALRCNVRIGLTGTILQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDPVEHGQRHTATKRELATGRKAMQRLARKMSGWFLRRTKTLIKDQLPKKEDRMVYCSLTDFQKAVYQTVLETEDVSLILQSSEPCTCNSGQKRRNCCYKTNSQGETVKTLYFSYLAVLQKVANHVALLQTASTSRQQETLIKRICDQVFSRFPDFVQKSKDAAFETLSDPKYSGKMKVLQQLLNHCRKNKDKVLLFSFSTKLLDVLQQYCMASGLDYRRLDGSTKSEERIKIVKEFNSTQDVNICLVSTMAGGLGLNFVGANVVVLFDPTWNPANDLQAIDRAYRIGQCRDVKVLRLISLGTVEEIMYLRQVYKQQLHCVVVGSENAKRYFEAVQGSKEHQGELFGVYNLFKLRSQGSCLTRDILEREGKVEAGIMTATTWLKEEPPVHKLETAREPDCREHRGPEQLAEAACDLCSDFSEDETASNSVTKTVKNKASDSSRASVSPGQFSLLQCGFSKLFETKCETVEDGDENIASDNESSDEQPTCFSTEAKNAGCQKSQDSLGTLKHQKLANVLNPNGKCVFEKSEKILKENIPSESDDEKNFKNTVDHHHILQNVTESEDSDIIFPTQYTTQRFLKKNIRFKPPVDGSEDSESENPVNIKNNGDDTKTNVRGNGLISKQLNLEIETLKSNTKRKGGSDISDESDDIEVFCKSRVRKQRATSSLRFKRKKENKRELYTFPKTMKKANQQCATDEDCNSQTIDDFSSSDDNLSVGHISFSKQNHRPKTIKDKISVSSKLTNHKRNSTFIPRKPMKFSNESVVNQNRICESMDKFLDGVQEVAYIHSNQNVIGSSKAENHMSRWAARDVFELKQFSQLPANIAVCTSKTHKEKMKGDISTRTKECQPLSEGSISFPLYISHPVSQKKKKVCRIDQTTFIIGETPKGIRRKQFEEMASYFKLSSVKEFAKRVTNATSEERQKMLRDFYTSQYPEVREFFVDSPSECTKSASEKGERVENKSEKRQSLMKEQPSDSETLSFKNSTKKISPIFSPSICKKKSIKFQNHSSCKKKVLSNDVETKKLPISCTQETDGGERSQASEGTAASCSLNSKSGADELGKLENAGKGQQDLTSLGISRNGPIFQVENKTIENPVLEDTSVVGLLGDTSILDDLFKSHENSPTQLPKKVLSGSIEKAKQRPKDFWDILNDQNDDSLSKLTDLAVIETLCEKVPFAASSKRKEDLEASLWKSNEKFLWKKFNSSDTDESTANTQE
The following text describes a protein:
Function:
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Sequence:
MNKNFEEQEKKAKGGVRLAREEVFKLVFGVEATESASEELKQAFDIYLQNSEELIGTLNENQLEFLKSSIDGIAKNYDNIKDIIKKNTQNWAYERIGVVERALLIVATYEFIFKNAPIEVIANEIIELAKEYGNEKSYEFVNGILANIEKSKK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MADGKDSLRLAPDEFKQLEVLRNRFHQLTHSLNSLFNDIQRSQPLPSQESLTASAAILQKSLETIQKLADENSDLFQRIVVHPSTNFPGRTQEHILLQLLRKKLEPEVESWVEDARSVAKASGLDPSKLASSQQRSNDYDDDDDDYRDEEEDAPSDPFNEQWADMFQVSMDSIRDYLMNQANEPYTIAEREMGIENVRTGLKRSLEEEDSEEEDEDEDEDEDRSLATAGLGNINAANLFHPEHVLWLASRGNMKVPKNVDLEAIRKREKPRGRPAPAQ
The following text describes a protein:
Function:
Involved in the biosynthesis of (+)-sesamin, a furofuran class lignan. Functions in a dual catalytic mode. Catalyzes the synthesis of (+)-sesamin from (+)- pinoresinol by formation of two successive methylenedioxy bridges on (+)-pinoresinol and (+)-piperitol, respectively.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MIGKAAWKKNFPPSPPGKLPIIGHLHLLKTPLHKTLNQFSQKHGPIISLRFGFRNAVVLSSPSAVEECFIKNDTLVLNRPKFLSGKLLNYNFTTLGAVPYGPLWKNLRRLTAVEIFSTARLNGFSGIRQDETNLLLKKLYQLSSRGGFVKVEMKSKLSELSFNIVMRIVAGKRYFGDHEMENESEARRFRVLIEELSYLSGASNPGDFLPFLQWFDYQNLEKRMIILQKEMDSFLQGLIDERRRNGDCGGEKTTMIDSMLALQVSEPENYSDQIIKGIILVVLMAGTDTSAVTMEWSMSLLLNHPDVLNKAKTELDRYVGESRLVNEHDITKLPYLRGIINETLRLYPAIPLLVPRESSHDCKIGPFDVPGQTMLLVNAWAIHRDPRVWVDPERFDPDRYAGLEDEDYRYRLVPFGAGRRKCPGSGLANRVVALALAALIQCFEWERIGGGEAVDMAEGGGLSMPKAVPLEAMCRAREDMMHLDSHTAKLLVISHHVPRSSQFHRRILIGHTPTTTAAAPALKPPRNNQVHQEIDPINPRKNPVKTIKPANIKIIPQPPLPLPPAGSSLHHLNNGGAQPTPDPNLTQEHRTAYTPRTVSRLVVEKLQLPHVRENLRRTHQKKLREEPENTQSAAAVVVVGARMK
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Also a component of a complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDETYEENEKVLVHHQNRIYEAKIIKVDPKTSKSDKKKPLYFIHYLGWKEKWNEWIEPNKILKYTDKNRELQKRTNIKASTTSLNNKKNTKKAKEVKQQQQQQQPIAYDSENSDEDENESELEDGGGEDADEGGEDIEDQENNNNNDTGGEEADDNNTSPRSTGSSSSSSSSKSNNNNNNNNNNNNNNNNNNNNNNNNNNKRKRNDSKSSHFQSTKFIDIEIPLSLKNKLVDDWNSINNEKSILSLPKSPNVKDILNKIIEENDKSSECKEVINGIKQYFNKALGTLLLYKFERPQYDSILKTNPKKSMSDIYGAEHLLRLFVKLPQLLVISNLEEKTITQLKDAFEIVLEYLEKNSSTLFLKEYTIASSPYLKAASSN
The following text describes a protein:
Function:
Calcium- and calmodulin-dependent protein kinase required for arbuscular mycorrhizal (AM) symbiosis. Involved in response to water deprivation stress. Required for abscisic acid-induced antioxidant defense and oxidative stress tolerance during dehydration stress. Functions upstream of MPK1 in an abscisic acid signaling pathway that regulates the activities of antioxidant enzymes and the production of hydrogen peroxide.
Miscellaneous:
MISCELLANEOUS: Can restore mycorrhizal and rhizobial symbiosis and induces spontaneous nodulation in a Ljccamk mutant of Lotus japonicus. Can restore nodulation and mycorrhizal symbiosis to a Medicago truncatula dmi3 mutant.
Subcellular Localization:
Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.
Sequence:
MSKTESRKLSDDYEVVDVLGRGGFSIVRRGVSKSEEKTQVAIKTLRRLGPAMAGMKQGTKPVPGSGLPMWKQVSISDALLTNEILVMRRIVESVAPHPNVINLHDVYEDVHGVHLVLELCSGGELFDRIVGRDRYSEFDAACVIRQIASGLEALHKASIVHRDLKPENCLFSDKDEKSTLKIMDFGLSSVEDFSDPIVALFGSIDYVSPEALSRQEVSAASDMWSVGVILYILLSGCPPFHAATNREKQQRILQGEFSFQDHTWKTISSSAKDLISRLLSVQPYKRPTASDLLRHPWVIGDCAKQDLMDAEVVSKLQKFNARRKLRAAAIASVLSCKVALRTKRLRNLLGTHDLTSEELDNLRLHFGRICADGENATLSEFEQVLRAMKMDSLIPLAPRVFDLFDNNRDGTVDMREILCGFSSLRNSRGDDALRLCFQMYDADRSGCISKEELASMLRALPEECLPGDITEPGKLDEVFDQMDADSDGKVTFDEFKAAMNKDSALQDVLLSSLRPQ
The following text describes a protein:
Function:
Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
Sequence:
MSDEGSRGSRLPLALPPASQGCSSGGGGGGSSAGGSGNSRPPRNLQGLLQMAITAGSEEPDPPPEPMSEERRQWLQEAMSAAFRGQREEVEQMKSCLRVLSQPMPPTAGEAEQAADQQEREGALELLADLCENMDNAADFCQLSGMHLLVGRYLEAGAAGLRWRAAQLIGTCSQNVAAIQEQVLGLGALRKLLRLLDRDACDTVRVKALFAISCLVREQEAGLLQFLRLDGFSVLMRAMQQQVQKLKVKSAFLLQNLLVGHPEHKGTLCSMGMVQQLVALVRTEHSPFHEHVLGALCSLVTDFPQGVRECREPELGLEELLRHRCQLLQQHEEYQEELEFCEKLLQTCFSSPADDSMDR
The following text describes a protein:
Function:
Multidrug resistance transporter involved in resistance to the antifungal drugs miconazole, tioconazole, clotrimazole, and ketoconazole; as well as to quinidine. Decreases the intracellular accumulation of clotrimazole in and plays a role in the extrusion of this antifungal from preloaded cells.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMEDQQSLHSFISDYDQRSHAVEKYDGPDLSEVDSEDNDKMIKTNEDEAVKEPIYRTRSNQTEPDIANAPPYSRFDAKYKMALVLQCAYTGLFSTMAGAIYYPVLSVIEKQFHITEELVNITVVVYFIFQGIAPTLMGGLADSLGRRPVVLFAVTVYFGACIGLACAQTYAQIVVLRCLQAAGISPVIAINSGIIGDVTTRAERGGYVGYISGFQVLGSAFGALIGAGLSSRWGWRSIFWFLAIGSGVCLVFSIIMLPETKRTIVGNGSVTPRNYLNRAPLLMFPLIRRKLHLDDPEYETLEPRTQLSLLAPLSILKVKEISILLVTAGIQFATWSTHQTALSTVLSKNYHLSVAKIGLCYLPTGICTLISIVTSGRYLNWSYRRRFAKHKVWLKEQEEILVKENGYSREEVQNIINNDPKYVFNLVQTRLHAAFVTLLLSSSGFVAFGWCIDVKAPLASVLVMSGFASLFSNCILTFSTTLIVDIFPSKTSTATGCLNLFRCLLSALFIGCLSKMATSMTYGGVFTFLGALTALSACPLFYLLKNGREITLKRKRKEDASRAFALSVANEKAEAEGKAEESR
The following text describes a protein:
Function:
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSFQEQQCKQPCQPPPVCPPPKCPEPCPLPKCPEPCPPPKCPEPCPEPCLPSPCQQKCPPVQTPPPCQQKCPPKSK
The following text describes a protein:
Function:
Component of the Set1C/COMPASS complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face. SWD1/CPS50 acts as an assembly and regulatory hub for COMPASS complex formation. Serves as a highly utilized surface for COMPASS interaction with the nucleosome.
Miscellaneous:
MISCELLANEOUS: Present with 907 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MNILLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPDFEEVEENVDYLEKEDEFDEVDEAEQQQGLEQEEEIAIDLRTREQYDVRGNNLLVERFTIPTDYTRIIKMQSS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MALQYLCPLCPYETRSRGILYRHLLIHTGVKPYCCEHCGRRYALPETLLRHMAAHRKKPPYQCSRCTLALDHFSEYLRHQVYHMLKSIHRCSSCGEGFVWKQALKHHSRLHKDSRHLFHMFFRRQAKMATARQAARFPGGANENDMPLDLKMPPVKVKAELSERPLNLKSTNSNNHGQGRLDQDRTLGLLQCPPLQSPLGNLLMPGCSPLLDNYFKFYMYPHLNLLPYQNGGAGLASPDSPVANGGESGLLVCRVCGWQFTKLSHLTAHMYVHTGRRLHSCEVCSKTFTRKGSLKLHRLQHLDEKPYQCDICRKTFLQARYLRAHLLVHRRQEASSLPVEPELGDAVPPASAPVFPAVFGTAMPTPDLSVPEPEAVESPESSSGATPSGSSPHRCPVCQKGFSQPYKLRRHLVIHASPRIHQCNVCQKVLPSVTELRSHKKSHGRARLHCCDYCKKDFSCSSTLRRHVRIHTGEKPYQCEVCFKRFSDLSNKNCHMRTHTGEKPYRCQVCSMKFSLKNALNCHMRNHML
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MAAPPRSLSAITALKQRCEDRLKHDEAKVKFLQDSVDTTSKTVDSMVGSARASQRLRSRDNLKKLLDLAKHVETYYGASIKLAPILEPGPAYNLEGYLAALKQLEEANLYFQRNNPRHPDVAHIQTLRRRAHQMMEKEFTTLVERFSVAADRDAVVMALEEQERDLERHGRLGEAPLALESDTVETLAGLVGWLEQTDEHAQCVKQYVKQRSRCMNDLMATARDESPLITPQSSLPRARSQINSKTPTRGFLRRPSEVRARRNTEASVLGRSHDSAAINYVQGTDPVLQHIRAFLAGARQELTLVQNIFSEDLQAAILHDVVLPAMEALRTSVRTMLDNSNRHLTEHSFFNLLNIYDVVTELHRKEPCFAAVLRYTEDGMFQAYMGMMLSVAEFGRRVTLEFQDMINTDASKKLPLDATVNELTAQALKFVNHAIDYREAVATVLRPDLAATRGELNWLKGEDANNMFCDWLRPVISTLTSNLLRKSRGYEDESVAAVFLLNNYSYIVRSLDSERFRDVMGQAASA
The following text describes a protein:
Function:
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity.
Miscellaneous:
MISCELLANEOUS: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization.
Sequence:
MVHHSGSIQSFKQQKGMNISKSEITKETSLKPSRRSLPCLAQSYAYSKSLSQSTSLFQSTESESQAPTSITLISTDKAEQVNTEENKNDSVLRCSFADLSDFCLALGKDKDYTDESEHATYDRSRLINDFVIKDKSEFKTKLSKNDMNYIASSGPLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIASPDIMFIKIHIPWDTLCKYAERLNIRMPFRKKCYYTDGRSKSMGRMQTYFRRIKNWMAQNPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAFPPHEGAYKSSQPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGLFTMNNSQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVMEQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIHDASIPQWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQEMMYEAELEHLQQQRRKSGQPVHHEWP
The following text describes a protein:
Function:
Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
Sequence:
MILITGANGQLGTELRYLLDERNEEYVAVDVAEMDITDAEMVEKVFEEVKPTLVYHCAAYTAVDAAEDEGKELDFAINVTGTKNVAKASEKHGATLVYISTDYVFDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKNFVFTMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDTTWYDFAVEILKDTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQEFYKQEVR
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for glutamine; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MNLLFAPNDCREGGAVPLPARIVGILIAFLLVTLIFAYAFHSLQYHWGWESVYAYRQKFVNGWLMTLAISAAALLLSLAIGLCTALTQRSRLLPLRYLGRIYVETIRGTPLLVQILVFFYVVADAFGVGDRYLVGVITLSLFAGAYISEMIRAGIESVGDSQMESARAIGLTRAQIYRYVVFPQAFRQTLPPLAGQFASIVKDSSLLSIIAVSEFTLNAQEVNAFTYSTLESYLPLAIGYLAITLPISLLSRRLEKKFRYAT
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MMRMRENSFLQLLLLLAVMVVAAVPFAGGHTDTFGSNTLMIGNACKETQYPEMCTSALAAVGAEKRAKKPRDFFDMSLEFAITKAHHARVIAYNLTFPNHDAAMYPPTGTYDCVELLDNTLALLDDVTKTPSDEDIETWLSAALTNQETCSESLAIKPPTKKEVIDSEAERMTHIISNSLSLHKSTKKNNKRQGRGSAGLERKLLADDFPEWLTERDRRLLQASPEEITPDAVVALDGTGTHTSINEAIAFVSLAKSKSKKSKSKKSGGGSSSSSGGRQVIHIKAGTYKETIRVATKQKNVMLIGAGKGSSVIVGSRSAGSGWTTYNSATVAGMGQGFICRDLTIVNNAGSGNHQAVALRVGADRSVIYQCSIQGHQDTLYAHSNRQFYKQNDIYGSVDFIFGNAAAVFQSCNILPRKSSAGWSTITAQGRRDPNQNTGFSIQGCKISSDGVRAYLGRPWKKYARVVFMESYLDSSIESRGWLAWSGNFALSTLFYGEYGNSGPGSSTSNRVKWSGVHSSMSSSEASKFTVSNFIYGNMWIPKSGVSFSSGL
The following text describes a protein:
Function:
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity). Interacts with p24beta2 at endoplasmic reticulum export sites for endoplasmic reticulum exit and coupled transport to the Golgi apparatus. Once in the Golgi, interacts very efficiently with the COPI machinery for retrograde transport back to the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Cycles between the endoplasmic reticulum and Golgi via COPI and COPII dependent pathways. Mainly located in endoplasmic reticulum.
Domain:
The cytoplasmic C-terminal domain contains a functional dilysine-retrieval motif, which is involved in the retrograde Golgi-to-ER transport of the protein.
Sequence:
MAINRIAHGSLFLTVVLFFLTVNYGEAIWLTIPTTGGTKCVSEEIQSNVVVLADYYVVDEHNPENTPAVSSKVTSPYGNNLHHQENVTHGQFAFTTQEAGNYLACFWIDSSHHLANPITLGVDWKMGIAAKDWDSVAKKEKIEGVELQLRRLEGLVLSIRENLNYIKDREAEMREVSETTNSRVAWFSIMSLGVCVVVVGSQILYLKRYFHKKKLI
The following text describes a protein:
Function:
May insert into membranes and form chloride ion channels. Involved in the formation of the excretory canal. Required to prevent cystic lumenal expansions in the excretory cell. Not required for formation of the initial tube, but is required for regulating the size of the tube lumen as it grows.
Subcellular Localization:
Cytoplasm. Membrane; Single-pass membrane protein. Note=Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Localizes to various tubular membranes in distinct cell types, including the lumenal membrane of the excretory tubes.
Domain:
The N-terminal part (1-55) is necessary and sufficient for translocation from the cytosol to the membrane; Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as a chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).
Sequence:
MAEAYQIQSNGDPQSKPLLELYVKASGIDARRIGADLFCQEFWMELYALYEIGVARVEVKTVNVNSEAFKKNFLGAQPPIMIEEEKELTYTDNREIEGRIFHLAKEFNVPLFEKDPSAEKRIENLYRNFKLFLRAKVEFDKGKKEPSRVEDLPAQIKVHYNRVCEQLSNIDQLLSERKSRYLLGNSMTEYDCELMPRLHHIRIIGLSLLGFDIPHNFTHLWAYILTAYRTAAFIESCPADQDIIHHYKEQMNLFTNQRETLQSPTKTHTIPEKVLSDIRVKGLAPDVNVH
The following text describes a protein:
Function:
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
Sequence:
MAASAKKKNKKGKTLTLTDFLAEDGGSGGGGTTFVPKPVSWADETDDLEGDVSTTWHSNEDDMYRVAPIDRSILPTAPRAAREPNIDRSRLPRSPPYTAFLGNLPYDVTEESIKDFFRGLNISAVRLPREPSNPERLKGFGYAEFEDLDSLLSALNLNEESLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRDDSFGDKYRDRDRYDSDRYRDGPRRDMDRYGGRDRYDDRGSRDYDRGFDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWGPRDDYSSRDDFRRDDRGPMQRPKLNLKPRSAPKDEDPSASTSQSSRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEENQERSRTGSESSQTGSTAPSGRTTRRRESEKSLDNEAFNKDDDSPSPTSKTPRAEQPPLKVVPAPPPKENAWAKRSSNPPPAARSQSSDSEPPSPLPAPIGGGPPTTSWPSLPADENKVDGANEKNAPKGQSGGRGPGEGTNKDHWKDPDSEPSPSIRVPKPRRTPPGKPWSRRGRRRGPPVVSSNTKAWRSGWSWGLGVRRTWLLIPTPPLVGWVILDRSLHFSGPRLPHP