lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.
Sequence:
MASNPALKWEQLAGKFYSTHEYDYELERDGREIDFDSSVVALAPGGGAVAVTDDEHKLVAMGNAARQMSIGVFSGSGNLIRRLPWDMGRIRGLGWTTEGEKLVVVSDQGSVRVYYDFHGNFNQFSLGLDAETAGVKETKFWNSGFVCLLNNGQFIGVLRAHSESPVPRKLAEPVTEKIHSWCIIPPEVSMSRGVEVVASTEQGLMTLDSLDSSTKKFDKKAEVQPVFNGLTVSPSGHHMALVGNTHVTMGDVSLDRIYGKYELEENVDQPIRTLCWLGEDAVAISFGDEVSLVGRENGSQLTLYYNGDGAVEIRGEDDGSIRIMGNNSHHLFSRVCDAALSIFRIGSVAPAAILLDCVTHLDKQSPRAWENLEIIGPDLQTAVDNCILAAGNEDSPSLQKRLLRAAAFGKSALDIYNSERFVQVCDDLRVLNSVRQSEVGLCLSYQQYKLLGPKKLIQRLLLRSLHQLCFNIADVLKYPVSAIEVNWACSKIFHSPESTDEELYKAIMNRLKDRRGVSFCEIARQAAQDGRVRLATQLTEQEKDAYKQVPLLMELGDDRLALEKAVECRSYDLITLVQLHLQDTLSMAQLYKLIREFPIASHVYENNAKVNSKEALEQYYYQSDRQTDSANCVYLNALGQNLNSEKLEGFRKAASMYSEHGSVGDAAIIEEQSKLLKLQEQLERDYECNFLGLSVTDTIHNLLVMGQASKALKIKTDFKISERKWTWLKLNAYVERRDWTGLMEFATSRRSPIGYVPFYDACMAAGSKRNAAEYITMTALDADVDERVQMALKADDVSKAAKEAFGGKRGDLLEELESKASGATVEEIQGMIEELRLAQK
The following text describes a protein:
Function:
Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the cox2 protein into the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MLQTLIGVHSYMPWCYEIPAMAIFLRSTITLPIAIASLKTARRFVQVQPLIKEAKKRCRTNTDFRTVRKKLYKRFNCHPLMIYALPITQLPLFAFASYQLRQAVDVCPESMSTEGMLWFTDLTLPDPHGVLPAVLAVTYLTNMSILKRPSDSRLLKIFNTAGIMSAFFVSFMAFKTSTALSLYWTTSAIYSLVQNVALRKLL
The following text describes a protein:
Function:
Transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway. Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes.
Subcellular Localization:
Nucleus.
Domain:
The DELLA motif is required for its GA-induced degradation.
Sequence:
MKREHQESKGDSSSSCSAMAKGKLWQEEEEQQQQDGGGMDELLAVLGYKVRSSDMAEVAQKLEQLEMVMGIAQEDGISHLSDTVHYNPSDLSGWVQSMLSELNNPLDTIQNQQDSSSVISFGNSQSGIFNDDSEYDLRAIPGVAAYPPQPESSDSNNNSSSRKRMKTSTLANSDSTIPTNLSEPNRPMVLIDSQETGVRLVHTLLACAEAIQQDNFKLAEALLKHIGLLAASQASSMRKVATYFAEALARRIYKIYPQESLDPSYSDTLEMHFYETCPYLKFAHFTANQAILEAFGTANRVHVIDFGLKQGMQWPALMQALALRPGGPPAFRLTGIGPPQSNNTDALQQVGWKLAQLADTIGVEFEFRGFVANSLADLQPEMLDLRPPDVETVAVNSVFELHRLLARPGGMEKVLSSIKAMKPKIVTVVEQEASHNGPVFLDRFTEALHYYSSLFDSLEGSGLNVPSQDLVMSELYLGRQICNVVACEGAHRVERHESLPHWRTRFESAGFDRVHLGSNAFKQASMLLALFAGGDGYRVEENNGCLMLGWHTRPLIATSAWQLSDSK
The following text describes a protein:
Function:
F-box protein component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). The SCF(DIA2) complex is specifically involved in the pheromone induced degradation of phosphorylated TEC1. The SCF(DIA2) complex binds to DNA replication origins. Involved in DNA replication, genome stability, and the control of cell cycle, probably through its association to replication origins to facilitate the ubiquitination of another origin-binding protein. Required for invasive growth and growth under alkaline conditions.
Subcellular Localization:
Nucleus.
Sequence:
MSSPGNSGVAIDSTVLKAIELGTRLFKSGEYLQAKRIFTNALRVCDSYSQEQIMRIRNAYQLDTARPDNKRLYHPRYIKILDNICACYEKLNDLKSCLDVSQRLLKLEPGNIKCYIRCTRTLIKLKDWKRAYKTCSRGLQLCNNDSNHLRQQKQFIKNNMVQKQDGKRSYIDPLEETKIAKKKKNNNVLESLPKKKIKGSTKKTDLVGNLPIEILPIIFQRFTTKELVTLSLVCNKWRDKILYHLDCFQEFNLAPINFKNFVKFMDFLQQNFTRTYRKYILSQVKVSSRITSEELRITQLLFSKMPKCINIERLILSMPTLTTTQIFKLMVRGGTDFFTRLLELSLMITYRPDKQHELEILQTCPLLKKIELIFVNSLVPIFDGNNSVGRDGSFNVMARHTNMQISTADNDEQGIVEEKVIYSELEKITLICDKKKIKNFPLCRALLRGQFPLLQKLTITGVTFPMNNQDIMNFQWLLNFPDLKELWIEDNDNCELSKFLQLLKFSNVWKNLEKLTFRENKLYPIVNLDEDQPVTNDDEVPSMLFYKENLQNLEKLDLMGTSISGSALTRLCEQEYLDGRKLRSLNIGNCPNIQFPNNHAHTARMILDVNAVLKRLSKLEEINLSHLSSLNDSTMKSFIINVPFLENLKRLDISHNFEITGISIYEFLKKFQMDHDNEAGGQPLAYLNIDGCSQVSHITVNMIRAQNLVTQVDCVYERDVWRKFGINSYSYS
The following text describes a protein:
Function:
Negative regulator of transcription elongation.
Subcellular Localization:
Nucleus.
Sequence:
MVRKSTRRTAKASEKPPETVVRCVCKSQEDIGDTWVQCDGCDCWQHASCVGLADKDIPESYYCEVCHSRSDVSSQVQNSPNKDEEHQTADLLASNEGNEKNNEENNVVSSDSKEAITKESGAELESSEPASTNSNVGMTTRSGRQSPRTPIGSTTPKSSHSPPSTRKRRGSVGTTATHTKRSKNAPKTSPKDASNETADQEKELSLHTSIDEIQNPVRKSVAKAWVSVFEKIIEKAKLEGVQGLEDLNSTSLALQLEHIMFMVLSYTTDHSLTPNNKYREKFRALRFNLVDDKNPAFRARVLKNEISFNDLVNLSSEEMANPDLKNLAEEIRQQSTENTVIKQHLIAPRDRLLDEDKLTQQDELGIAENDDAMFPKPPGELVAPISIAEEEPTIDSKSPTLPEHNPLSEDDTSNGDKAAKRKGSFNDTKPIVNVPSIVEIDDPTILDIVEEEPLARNDSFSSPYSPAEDMAEESEFFGMKEKIWTGKVKMATVSEFHANALNLFGDVSASHLFEILSATALIEGRISVSSVLQYFHALRKTPSKEIIAVLFVPTEQNSQGFDILYDYFVKRNRYGVLHSKSNSVKDAYIIPMPSGNSVPELLDLLPKVDLPKDRNFQYFMGLFVLNKSSSRHESVERATPITTSTNGIPSTYQSASGTPTNPVHSYPSLESIINALTPSDMLLIKDVVENNPQIRANPSLAINPQFMQNAISAAQKKASKQ
The following text describes a protein:
Function:
Component of the 40S ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MAIYRQNPQVQKPAPAVSTCVLSGFSAAARSRQSLRHCRGHPRPREGPDRGRGEAARKRRCAAHAPSFLAPAPYAVAAAMLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGFVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARFTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ
The following text describes a protein:
Function:
Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly located near the cell surface.
Domain:
The DOCKER domain may mediate some GEF activity.
Sequence:
MAASERRAFAHKINRTVAAEVRKQVSRERSGSPHSSRRCSSSLGVPLTEVVEPLDFEDVLLSRPPDAEPGPLRDLVEFPADDLELLLQPRECRTTEPGIPKDEKLDAQVRAAVEMYIEDWVIVHRRYQYLSAAYSPVTTDTQRERQKGLPRQVFEQDASGDERSGPEDSNDSRRGSGSPEDTPRSSGASSIFDLRNLAADSLLPSLLERAAPEDVDRRNETLRRQHRPPALLTLYPAPDEDEAVERCSRPEPPREHFGQRILVKCLSLKFEIEIEPIFGILALYDVREKKKISENFYFDLNSDSMKGLLRAHGTHPAISTLARSAIFSVTYPSPDIFLVIKLEKVLQQGDISECCEPYMVLKEVDTAKNKEKLEKLRLAAEQFCTRLGRYRMPFAWTAVHLANIVSSAGQLDRDSDSEGERRPAWTDRRRRGPQDRASSGDDACSFSGFRPATLTVTNFFKQEAERLSDEDLFKFLADMRRPSSLLRRLRPVTAQLKIDISPAPENPHFCLSPELLHIKPYPDPRGRPTKEILEFPAREVYAPHTSYRNLLYVYPHSLNFSSRQGSVRNLAVRVQYMTGEDPSQALPVIFGKSSCSEFTREAFTPVVYHNKSPEFYEEFKLHLPACVTENHHLLFTFYHVSCQPRPGTALETPVGFTWIPLLQHGRLRTGPFCLPVSVDQPPPSYSVLTPDVALPGMRWVDGHKGVFSVELTAVSSVHPQDPYLDKFFTLVHVLEEGAFPFRLKDTVLSEGNVEQELRASLAALRLASPEPLVAFSHHVLDKLVRLVIRPPIISGQIVNLGRGAFEAMAHVVSLVHRSLEAAQDARGHCPQLAAYVHYAFRLPGTEPSLPDGAPPVTVQAATLARGSGRPASLYLARSKSISSSNPDLAVAPGSVDDEVSRILASKLLHEELALQWVVSSSAVREAILQHAWFFFQLMVKSMALHLLLGQRLDTPRKLRFPGRFLDDITALVGSVGLEVITRVHKDVELAEHLNASLAFFLSDLLSLVDRGFVFSLVRAHYKQVATRLQSSPNPAALLTLRMEFTRILCSHEHYVTLNLPCCPLSPPASPSPSVSSTTSQSSTFSSQAPDPKVTSMFELSGPFRQQHFLAGLLLTELALALEPEAEGAFLLHKKAISAVHSLLCGHDTDPRYAEATVKARVAELYLPLLSIARDTLPRLHDFAEGPGQRSRLASMLDSDTEGEGDIAGTINPSVAMAIAGGPLAPGSRASISQGPPTASRAGCALSAESSRTLLACVLWVLKNTEPALLQRWATDLTLPQLGRLLDLLYLCLAAFEYKGKKAFERINSLTFKKSLDMKARLEEAILGTIGARQEMVRRSRERSPFGNPENVRWRKSVTHWKQTSDRVDKTKDEMEHEALVEGNLATEASLVVLDTLEIIVQTVMLSEARESVLGAVLKVVLYSLGSAQSALFLQHGLATQRALVSKFPELLFEEDTELCADLCLRLLRHCGSRISTIRTHASASLYLLMRQNFEIGHNFARVKMQVTMSLSSLVGTTQNFSEEHLRRSLKTILTYAEEDMGLRDSTFAEQVQDLMFNLHMILTDTVKMKEHQEDPEMLIDLMYRIARGYQGSPDLRLTWLQNMAGKHAELGNHAEAAQCMVHAAALVAEYLALLEDHRHLPVGCVSFQNISSNVLEESAISDDILSPDEEGFCSGKHFTELGLVGLLEQAAGYFTMGGLYEAVNEVYKNLIPILEAHRDYKKLAAVHGKLQEAFTKIMHQSSGWERVFGTYFRVGFYGAHFGDLDEQEFVYKEPSITKLAEISHRLEEFYTERFGDDVVEIIKDSNPVDKSKLDSQKAYIQITYVEPYFDTYELKDRVTYFDRNYGLRTFLFCTPFTPDGRAHGELPEQHKRKTLLSTDHAFPYIKTRIRVCHREETVLTPVEVAIEDMQKKTRELAFATEQDPPDAKMLQMVLQGSVGPTVNQGPLEVAQVFLAEIPEDPKLFRHHNKLRLCFKDFCKKCEDALRKNKALIGPDQKEYHRELERNYCRLREALQPLLTQRLPQLMAPTPPGLRNSLNRASFRKADL
The following text describes a protein:
Function:
Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MDFSVISDNLSYLLLGAYPDGPLGGAALTLLLASLSGLASAVLGLVLGVALAVLPGKPRLLLVALLGFFRAIPVLMLIFWTYFLLPIVFHVDVPALATVVCALSLIGGAYLAHSVYAGIHSLPAGQWAAARALGLRPWQVLRLVILPQALPVMLPSFLNQWVSLIKDTSLAYVIGVGELSFVATQVSNRVMVHPTEIFLFVALLYFLLCTSLDLAAAFLARRRRA
The following text describes a protein:
Function:
Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At metaphase-anaphase transition, this protein is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm. Note=Shows cell-cycle dependent localization to chromosomes, with an accumulation on chromosomes apparent during mitotic interphase and telephase, but more diffuse nuclear expression during prometaphase, metaphase and anaphase.
Sequence:
MFYAQFVLAKKGPLAKVWLAAHWEKKLTKAQIFETDVPQAIEEVIRPKVKMALRTVGHLLLGIVRIYSKKTRYLLADTNEAYQKMKINFRNGFSFEVDIPENAEIEEDFSNFIDKYNITVPEFHDADYNEQLIMANVSRREDITMKETVNFNVEFNIDADFDGFGDEGESWQLDHLYGSVEPLSLRPTPQPESLMEVERDRDVAANGTEISRIDADSVIFSEGPTRPNLIFDNQEGGNFMPEMNLKVENQTLENDGGVGPADMFSSMIHPVREHAVADVQNDDGMDFDYQPFEPENVEPSRPQSPESFALEPLDVEHMEGRKKRQRKARKLIVDAETMISNDAFREQQEDFSDTMRVVEMAPPTRKMFNLCVSGDLQHLSREPGCKMFNRELLQRYRRCLVTREFDLNYTMQELSDSSSFTPSMEAQAEPWEDLNLNEDIQEDIQAQGPAVDEFFNDVRMDDDDDRQPAQEMDFGDNFDFPQEVEHQECAPIPIQSGFAGENKENEDAEDWSDPFGSSNSSRRGQLEAYGFGNTSTYKEDDGKWAKRAKHILKKVSADIETSGQADFSSVTATAKNRKQAAEQFYSLLTLAKSQAISVDQSEPYGEIVIRPGANFKEACPLSSPKPMGLGNTMENSTMRTPMRPV
The following text describes a protein:
Function:
Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
Subcellular Localization:
Cytoplasm.
Sequence:
MGDEDRNLIEILEENSPIDFNKYIGYVSSPKCGAIATFAGTTRDSFDGKEVLELRYEAYIPMAIRCLKSLCTSARASWDIHSIAVAHRLGTVPVGETSVFVAISSVHRADSLDACKFMIDELKASVPIWKKEVYTNGEVWKENKEFIERMPDLGKTSHDQGSACSGKKKVEAHERKSCCGTKVKVSDESADSFR
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MDEDFEKRYFEMEMRLNRTLQENNKASIDEISNSYGLKQTRLAPTNQYDIPIAYLSKQASYGPSSEDHLKDKDVYRYLRSINKLPETLFKEYQDRKEKGIKTSEDYAKPEAVDRLQKDLIKKQEKSKARNERAGNYDISGKTSVDFINDNNRRFNRKLARAYDQYTEQTRINIERGGNV
The following text describes a protein:
Function:
Involved in male fertility. Required for manchette development and acrosome biogenesis during spermiogenesis. Binds in vitro to phospholipids, including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Contrary to other profilin family members, does not bind to actin in vitro.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSWQQFVDESLLGTSQVAKASIHGLNGERYASSSGFVVLPSEAQVLIAAITKDPSPTYYKGVCLNRTKYFVIRVDPGHSLYCRKGNEGAVAVLTSQCLLIGAYSEGMTPGCCSAVTEKLADYFRVNGF
The following text describes a protein:
Function:
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MSQVPVASSQQRSVSAGNHPSSSSTSSSFAVPFSSTSATSTPLLAQGSLHAGSPTSNHLSSSPYAAAGSLPAAATPASLSHQHSSSLVGTPAILATTSFRKLVWDGTIPICVSVDPAELPPGSDATIDSTYLVVPRISYLPLIIADVRRNLLELVLEQPALNVLNEKELWFEYEGQPLRWHWQIGLLYDYHTSNPARTAIAYQSSSTNTTGLGSLRPNTPLIPQGGSDTEFSSAAQPSRLPWNIRLRLSKLPVERLHSNSGLESCKTSFMSMIKEADFVRYGSTKKVVNLRKQEQDTLWDSVVSHDYELFWSIANKLVPNAGVSGSDAAAGNGLALGRSPIAARTMSLNLGGTQEDRTNASAQRSLTTLQNESQASLAPSTLSTLTSTTSSDPTSATNSTPTSSAGNSVRSIPIRFFLPDNAPIVQEPVPPTLDDGRANTLAAVLSALFPLLFPPPPSFSSFQAPAPPLAYALVQGVRMPLDTEIAWLGSALVGPDGWVSVVVGLVS
The following text describes a protein:
Function:
Probable transcriptional regulator.
Sequence:
MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQKEVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGAYRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQDIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSNRPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEMPGELLDEPVNLSFEEELQK
The following text describes a protein:
Function:
Probably involved in membrane trafficking.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein.
Sequence:
MSRFTEKNPFDDETDANPFADPAIKSHSPGAGAYGGGAYSGGGTFYQEPSVAPAKPTPLPPERASVTSFASDSATVDIPLGEPGYKKKEKELKAKEKELQKKEAELKKREEDARRAGVIIDTKNWPFFFPILHHDISADIPEAQQWTQRLAYYTYLGLMLCFLWNTVCVSAGWAKGVISGGSAFVCWLAAILYAVAGIVLAWPLWYKRLYNAMRRDRAMTFAWFFLMYLVHIAWCIFAAIAPPIFIKGSSLTGFLSFIKALDADTVVGIMYLVGCILWVLEALLSIFVLQRVYSYFRGSGKATEVKRQGARAVVQAAV
The following text describes a protein:
Function:
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
Sequence:
MFKKLFRQDENILNSELAEDLPIPRHVAIIMDGNGRWAKKRFLPRIAGHKEGMDVVKRVTRYANAIGIDVLTLYAFSTENWKRPTDEVDFLMKLPVEFFDSFVPELIEENVRVNVMGYRENLPDHTMRAVEKAIADTAHCTGLTLNFALNYGGRSEIITAAKEAMKELELEGKSADDLTEEKLNDHLMSSGLGDPDLLIRTSGELRLSNFMLWQLAYSEFYFTDTHWPDFSKEDFLQAIIEYQNRSRRFGGL
The following text describes a protein:
Function:
Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici; Promotes hydrogen peroxide H(2)O(2) production and cell death.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MAICNTCSSNSPLLLSFFTITISFCLTIIPLASALTFNYTSFSPQYDDNITYERAYPDSNRVIQLPANRETAGRATYNQSMRLWDKATGNLTDFTTHFSFVIDSRNSSYYADGLAFFLAPQGSKIPTNKGGGSFGLTKDNEPLNSSIPFVAVEFDVYVNSWDPTFSHVGIDINSVKSKKNVSWWSDVKSGRRNEAWISYNSSTHNLSVAFTGFRNNLVVMQGLDYQVDLRQHLPEFVTFGFSMATGVDFAIFSIYSWEFNSSLEMDDETTNPVSNPKRRRKNRTALVVGLSLGGGVLVGGVVLIIWLAGIGRKRKEGDEEDNQGFSEYIDDEFERGAGPKRFPYKELALATNDFNDDQKLGQGGFGGVYKGFFRETNSYIAVKRVSQGSKQGIKEYASEVKIISRLRHRNLVQLLGWCHEKKELLLVYEFMPNGSLDSHLFKENSLLTWEFRYKIAQDLASGLLYLQEEWEQCVVHRDIKSSNIMLDSNFNAKIGDFGLARLVEHAKGSQTTVLAGTMGYMAPECATTGKASKESDVYSFGIVALEIACGRKPINPKAPQGQVSLLQWVWDLYGNGKLLEAVDPRLCRDFDGQQIERLMIVGLWCAHPDENLRPSIRQVIHVLNFEAPLPALPPKMPVPTYLSPP
The following text describes a protein:
Function:
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
Subcellular Localization:
Cytoplasm.
Sequence:
MSYSKIPAGKDLPNDIYVAIEIPANHAPIKYEIDKDTDCLFVDRFMATPMFYPANYGFIPNTLADDGDPLDVLVVTPYPVAPGSVIRARPVGVLHMTDEAGGDAKLIAVPHDKLSVLYKDVKEYTDLPALLLEQIKHFFENYKDLEKGKWVKVEGWGNADAARAEITKAVAAFQK
The following text describes a protein:
Function:
Triggers stress-induced chloroplast degradation, independently of autophagy and senescence-associated vacuoles. After targeting to the chloroplast, triggers its destabilization and subsequent disassembly, inducing the formation of CV-containing vesicles (CCVs) carrying stromal proteins, envelope membrane proteins, and thylakoid membrane proteins which are released from the chloroplasts and mobilized to the vacuole for proteolysis.
Subcellular Localization:
Plastid, chloroplast membrane; Single-pass membrane protein. Plastid, chloroplast thylakoid membrane; Single-pass membrane protein. Plastid, chloroplast envelope. Vacuole. Vesicle. Note=Present in vesicle-like spots observed in destabilized chloroplasts; these CV-containing vesicles (CCVs) carrying stromal proteins, envelope membrane proteins, and thylakoid membrane proteins translocate later to the cytosol before being mobilized to the vacuole for proteolysis.
Sequence:
MAGRISCCLNLPPLDSNSAQSLASLLKTTSKISCRRTENETEPRKNKCSFVLGVAATVVIGGIQINDVASVEAAVVKSPVEEMAAGVVPPRRWSDKRTCPPWLENSLETIVPENLPRPSAHRRLELAGLAKGDAPPVGVVMTRVNRGGCFSV
The following text describes a protein:
Function:
Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid; Reversible hydration of carbon dioxide.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MEVAVLWFGPALLPLAQDGLLSLKNYKLGNNLPTDLDGKISGKKGETIQTKTYLLYLESLFRGYFLIFLAESSWCYEVQVCSTGCKGPRNWKHIYSECGGSQQSPVNIMTKNTTYNSLLRPFQFKGYNVTHALPITNNGHSAQVDLPTDAQISGGGLVGVYEAKQLHFHWGSADIAGSEHTIDGERYLMELHVVHRRKAIKEENISISKGDMAVLGFFFEVSPYFVHLNQTKSFPNCGQDYIVRFFLK
The following text describes a protein:
Function:
Involved in activating dmsEABCD gene expression related to dimethyl sulfoxide (DMSO) reductase. Required for anaerobic respiration on dimethyl sulfoxide (DMSO).
Sequence:
MADSTSGVAEAKADTLREQHLQLLLEIEPAKRCSCPLAGPDSAVEDVHTQLDGDVCHAEVTVGDGDASKVVHATTSVGDDCLCRAFAEFECVPRIRRADGECIVVETYLSDRAVITDLVERLDELTERVCLRRLTSDGRGDSTESKTATIDLSSLTAKQREAALIAVHHGYYETPRRTELATLAEALGISKSALSQRLNAVEAKLATAVFDSE
The following text describes a protein:
Function:
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MSRNKPLSKEEKRQRLKALFNETREVYLIKELEKIAPKEKGIVSKTVEEVLKELVDDGIVHSEKIGTSVYFWGFPSEEFVNKKVENERLEQEIRENCKRIEEVKEENEKLKRERGGDEGREMKEQEVERLRERKEEIMKELEIYKENDPDMIKKLKEQVQKSKEAANRWTDGIFMIQTYAKERVSVPIEELNKGLGIPNDLDYLD
The following text describes a protein:
Function:
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
Subcellular Localization:
Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Sequence:
MSFVPGQENAGGRSSSVNRAGNGILKKTTWADQTERGPNNQNRGRRNQPKQTATTQPNSGSVVPHYSWFSGITQFQKGKEFQFAEGQGVPIANGIPASEQKGYWYRHNRRSFKTPDGQQKQLLPRWYFYYLGTGPHAGASYGDSIEGVFWVANSQADTNTRSDIVERDPSSHEAIPTRFAPGTVLPQGFYVEGSGRSAPASRSGSRSQSRGPNNRARSSSNQRQPASTVKPDMAEEIAALVLAKLGKDAGQPKQVTKQSAKEVRQKILNKPRQKRTPNKQCPVQQCFGKRGPNQNFGGSEMLKLGTSDPQFPILAELAPTVGAFFFGSKLELVKKNSGGADEPTKDVYELQYSGAVRFDSTLPGFETIMKVLNENLNAYQKDGGADVVSPKPQRKGRRQAQEKKDEVDNVSVAKPKSSVQRNVSRELTPEDRSLLAQILDDGVVPDGLEDDSNV
The following text describes a protein:
Function:
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDSTNSPFTLLGKQMITPSPKTNKQRNSYRTKSSMSEADETLFGVPTRYAQQVETKRPSSGKQWDPPWVTSPTKKGAPLLWTPFDYKGFDDSLSPEGNENTRSNTKPRTPRSARTPNKYRLKKHTPTYVDETLFGSRLKDPSFQVPWSGSNNSNNNESKDISWSPDMKNLTPRPGEIIRPVCPLSVYDDPYIPPTPRDAPRSAPVIRARPGSLIKTPQKKSSKYGGVKQKLDFSDPDEKQKEELIQRALRLAQVSREAAEQNEMRLNLENARNDFTWKRPSSASTVHSQRNRPRSARMSDFQENENFLSATGVRVPLSARSDSGSRPNSARSRPSSARRSNMGGSSTDRPSWRP
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
Sequence:
MKGLVKFSRVFPPIEQSVLVQSWASPRAPPVPPAEKSQLVQSRPSHRLPGKKRKSLLGEPEVAPGGRLREAAAILWNGPAMAYRGQGQKVQKVMVQPINLIFRYLQNRSRIQVWLYEQVNMRIEGCIIGFDEYMNLVLDDAEEIHSKTKSRKQLGRVMLKGDNITLLQSVSN
The following text describes a protein:
Function:
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as BMP a antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MNRTAYTVGALLLLLGTLLPTAEGKKKGSQGAIPPPDKAQHNDSEQTQSPPQPGSRTRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
The following text describes a protein:
Function:
May be required for the assembly of mitochondrial cytochrome c oxidase.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MQFAHNSSIQKPTPPDKGSFPLDHDSECSKPMLAYVNCLSENNGLSRFCMEFSKEYLKCRMDNNLMAKEDMDNFGFEEVKKAKIVPAPHYNPNEPIVAGLSRRKRD
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAKSSHEGLRERKTAASTNGTADTTADSSSSMFLSRRAHSSPTVVNPFVANELRHATADAVKQILVDDFGFVEDHTISNVQLILGYVSSISIIAGSLYNFLVPFHQSMNLLLVSMAIYVVLNTALSAYNLLFAKDIMFVGVRKDHTGAGPDIHLVIRSKFEKYSETYLLKFGISKFKKGHPQAKSGPVAESILEKPYSAWFDVDGKLVPKRLYEDIARVASRNQLHLS
The following text describes a protein:
Function:
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
Sequence:
MLPLTAAITAGGASSRFGSDKALALWQGRPLLDQVAAGLAACERRLLIAPPGKYALPGWETWPDTRPGEGPLAGLEVALTHAAPGWVAFTGVDNPALTSDYWLTLLAACRPGMSSVQALHPERGPQPLGALYHTALLPRVTGLLAAGERRLRLTAPAEQTVLVTGLGAHFFQNVNRPADLAELSGRGEESLEV
The following text describes a protein:
Function:
Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).
Sequence:
MSEHHFRTGETLPPLKPGVLRLYTMAFCPFAERTRLVLAAKGIDYELVNVNTFQKPEWYFDKNPDGVVPTLEQDDKLIQESIVTCEYLDELYPDTAPMFPSDPYLRSRDKLFIQRFGKYISAFYQSAKQKGANEELRSAALKQVEWVEQELKKRGTPFFSGLSPGMVDFSIWPFIYRIPSSRSLGDGGLDSFVLLKQWMDRMRQDEIIAPRIVEDEALIEFSTHYRTPGSRFDEIQTKAVK