lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor 1 (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as a positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF1 and PDGF-induced mitogenesis (By similarity).
Subcellular Localization:
Cytoplasm. Membrane. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MNGAPSPEDGVFPSPPALPPPPPPSWQEFCESHARAAALDLARRFRLYLASHPQYAEPGAEAAFSGRFAELFLQHFEAEVARASGSLSPPVLAPLSPGVEIPPSHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGAVESPSQAGPLETTSGPPVLGGNSNSNSSGGAGTVGRALANDGTSPGERWTHRFERLRLSRGGGTLRDGAGVIQREELLSFMGAEEAAPDPAGVGRGGGAAGLTSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSTITDVRTATALEMPDRENTFVVKVEGPSEYILETTDALHVKAWVSDIQECLSPGPCPAISPRPMTLPLAPGTSFLTKDNTESLELPCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASFSPSSASIAASHFDSMELLPPELPPRIPIEEGPPAGTVHPLSTPYPPLDTPEAATGSFLFQGEAEGGEGDQPLSGYPWFHGMLSRLKAAQLVLEGGTSSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSQRQQERSTSRDPTQPSEPPPWTDPPHPGAEEASGAPEVAAATAAAAKERQEKEKAGGGGVQEELVPMAELVPMAELEEAIAPGTEAQGGAGSSGDLEVSLMVQLQQLPLGGNGEEGGHPRAINNQYSFV
The following text describes a protein:
Function:
Plays a role in seed and fruit development. Functions probably in association with CYP78A6 in the regulation of seed growth.
Miscellaneous:
MISCELLANEOUS: The gain of function mutant 28-5 (T-DNA tagging) in apetala2-1 (ap2-1) mutant background show enlarged and wide pistils and siliques.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MATKLDTSSLLLALLSKCSLLTQTNLALSLLVASLASLALSLFFWSHPGGPAWGKYFLHRRRQTTVIPGPRGLPFVGSMSLMSNTLAHRCIAATAEKFRAERLMAFSLGETRVIVTCNPDVAKEILNSPVFADRPVKESAYSLMFNRAIGFAPYGVYWRTLRKIASNHLFSPKQIKRSETQRSVIANQIVKCLTKQSNTKGLCFARDLIKTASLNNMMCSVFGKEYELEEEHEEVSELRELVEEGYDLLGTLNWTDHLPWLSEFDPQRIRSRCSNLVPKVNRFVNRIISDHREQTRDSPSDFVDVLLSLDGPDKLSDPDIIAVLWEMIFRGTDTVAVLIEWILARMVLHPDIQSTVHNELDQIVGRSRAVEESDVVSLVYLTAVVKEVLRLHPPGPLLSWARLAITDTIIDGRRVPAGTTAMVNMWAIAHDPHVWENPLEFKPERFVAKEGEVEFSVLGSDLRLAPFGSGRRVCPGKNLGLTTVTFWTATLLHEFEWLTPSDEKTVDLSEKLRLSCEMANPLAAKLRPRRSFSV
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Sequence:
MTILVTRPSPAGEQLVTRLRALGRVAYHAPLIDFSPGRDLPKLPELLQDMQAGDLVFALSQNAVRYANPLLKRNKLSWPVQLSYYAIGRTTALALHTASRLHVTFPPMGETSEMLLSLPLLQNLAGKKALLLRGNGGRELLGASLAERGAAVTFCECYQRSPIYYDGSEQSAHWQRAGVDILVVTSGEMLQQIYTLVPDYYRSSWLLRCRLIVVSDRLAALATQMGWTEVRVAENADNDALIRALQDLQ
The following text describes a protein:
Function:
Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements.
Subcellular Localization:
Nucleus.
Sequence:
MAAFLGETNHMGNHCDFSYEIWPDMESFLQEICPPNSFEEPSFAPRLETCSPASTVFSGAGSDGSTCLSPPPVSPESDAFAQVYDDLLDLDFIINNTSDLEAYSPEPSPEPITVPQQIKIKEEAASPIPGATPSDCIGHFFDDNLNFSNAFEAKVSPQQIQHQTQQQQQKHQYLLTGDIHHMQQLHHQQQQHHQQQQQYFQTFNVHHLQMASQLQQRSEGQSLPEPPPYSHQHLVAPQMTRLAMPQQQQLPQQHMMPTPPNTPPTSPLLDLLRNTPVDTAVPTSVPATQIVRRKGRRTWGRKRTTSHTCSHPGCGKTYTKSSHLKAHMRTHTGEKPYHCNWKGCGWKFARSDELTRHYRKHTGDRPFQCHLCERAFSRSDHLSLHMKRHM
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSSNEEVFTQINATANVVDNKKRLLFVQDSSALVLGLVAGFLQIESVHGFIWFLILYNLINVIYIVWICQLQPGKFYQSPLHDIFFESFFREITGFVMAWTFGYALIG
The following text describes a protein:
Function:
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
Sequence:
MTSSPNEPRKKKPDSRKISIKNPTNLKITKDTFKTGLNRHVHYTLMKDKNVADFFDYCRATCLCVRDLIALRWVRTQQFYYEMDVKRVYYLSLEFYMGRTLANTLVSLGNNKLAEEALYELGLSLEELEDLEVEAGLGNGGLGRLAACFLDSMASLGIPAYGYGLRYEYGIFKQVIKDGWQFEEPDNWLKYGNPWLTPRPEYQLHVKFGGKVHYQNKAAKWEQEETVLATPNDVPIPGYKNDHVNTLRLWVSKAPENFNFSFFNNGDYIKAVMMGNLCENISRVLYPNDNFFQGKELRLKQEYLLVSASLEDIIRRFKKSTFYIRNKGAMLKLHEKVAIQLNDTHPSLAVPELMRILVDVEKLSWDDAWKTTVLTLAYTNHTILPEALERWPVSMLESLLPRLMHIIYEINSQFMQEVAKKFSNDVSRMSRMSLIDEEGEKKVIMAHLCIIGCHSVNGVSAIHSQILKDKIFKDFYEMFPERFNNKTNGITPRRWLLVCNPGLADLINENIGTFWHRKLEGLTQLCKFAKVEAFCKKLQAIKKVKRIHEYKRQMLNILHIITMYNRLRADPAYNFTPRTVMIGGKAAPGYHKAKLIIKLFNNVASACNADPNVQKKLRCVFLTNYQVSLAEKIMPAADLSQQLSTAGTEASGTGNMKFMLNGALTIGTLDGANVEMREAMGAENFFLFGMNVNQVEELRANGYDPIRYYHANKELKEAIRQIDSGYFSPGDPHLFKEISSSLLSHDEYMVCADYESYINCQEKVGQIYKDQATWSRMVIMNIASSGKFSSDRTVTDYCNDIWGVQPNFDMMNLS
The following text describes a protein:
Function:
Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell surface. Endosome, multivesicular body. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Melanosome. Membrane; Multi-pass membrane protein. Secreted, extracellular exosome.
Sequence:
MVVEGGMKCVKALLYVLLLTCCICAVGLIAVGLGAKLDLNQTTNWEATPESLVPVVIIAMSICLFLVAFVGCYGAWKEDYCLMIMLAICLSLIMLAEVAAVVAGYMLEDKVMSESNKDFQQQIQNYQKNNHMSPIMDRMQEHFKCCRAANYTDWEYILLTTKRVPGSYCVSITKGCGINFSIKEMHAESCVAKTGGWLRSKVVIATGLSIAFMEVLVIVFACCLVKGIRHGYDDVRVL
The following text describes a protein:
Function:
Involved in plant defense. Required for basal resistance against Pseudomonas syringae pv. tomato DC3000. Required for resistance against nonpathogenic bacteria. May be involved in signaling components that function downstream of SNC2 and upstream of NPR1 and WRKY70 to regulate defense responses.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDSKLLLVTQSGSVDDLYSLIQAAPDILQKVDVLPIIHTPLHEASSAGKLDLAMELMILKPSFAKKLNEYGLSPLHLAVENDQVELALELVKVDPSLVRIRGRGGMTPLHLVAKKGDVDLLTDFLLACPESIKDVNVNGETILHITIMNDKYEQLKVLTGWMQKMRDSDDVFIDVLNRRDRGGNTVLHLAAYENNDKVVKQLVKCLSLDRNIQNKSGMTALDVLRARGSHMNKEIEEIIQMSGGKTGGSLSGIQEWYIFLREPVTFKEHCKTRIARYRSRISDGSRNALLVIAALIISATFQTAAQLLDKEKLDKVKKNGMRFSEFQLWGCNTVAFSIAILFSFILLPVGRAYEWWYFIITVPLVFSYFLLMYMMHGLSFFFLIIYEGGLFLVYLLVLYVKWKRCTQMKVRKPKSDLISDNFKNMV
The following text describes a protein:
Function:
Involved in 20S proteasome assembly. Required for maximal proteasome activity. Affects the chymotrypsin-like activity of the proteasome. Can be degraded by the proteasome. Involved in the endoplasmic reticulum-associated degradation (ERAD).
Miscellaneous:
MISCELLANEOUS: Present with 2940 molecules/cell in log phase SD medium; MISCELLANEOUS: Deletion induces the unfolded protein response (UPR).
Subcellular Localization:
Cytoplasm.
Sequence:
MSCLVLPLVSVGNIPQLSIDWLLNSQANEWEYLEALDSKYLVEFVGPLDRPEDGSDSLYKDADMKYSSALEVFYNKKRGLFAIQQRTPLVSVNYLNNFIVEIILPFLSKYNISEICIWDSLYAMEDENGVIVRPQEVYSLGEFYFDDEAELLSNLHLNDQESMVNNWLHFTPTSFQDKISVDQPIFKILFQILNASQRPKALRSIKYCSCLANEGDNSLDSQQFLQWIISQKVIKNAPPIVKFVRPISWQGAYGMADARDKFVDLYN
The following text describes a protein:
Function:
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
Sequence:
MRVGAHVSIAGGVDNAVTNELDVGGNCGQIFTHSPQVWQDPNIGADEAAAFREGTAADLDGPWVIHSSYLVNLCTPKDDLRAKSIDSMQAEVDAAHTLGIPYVNVHLGAHTGAGVDDGLDNAASALDELDIPDDVTVLIESDAGSGTKLGGDFEHLHEVLTRSDQDLDVCIDTAHAFAAGYDLSTEAAVNDTLAAFDDVVGLDHLQYVHLNDSKHACGTNKDEHAHIGEGHIGEAGMRAFINHDAIADVPLVLETPHEDGRGFAWNIDRVRDLRA
The following text describes a protein:
Function:
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.
Subcellular Localization:
Cytoplasm.
Sequence:
MITSFYAFLDYLKNMKASSLHTLRNYCMDLSSLKCFLEKKSDLSPTPPLSLHDNTYDYPPLSFSLFTKDNIRLYLLEQIQTHHSKRTVRRRLSAIKSFARFCVKNQLIPENPAEMIRGPRLPQELPSPLTYEQVLALMAAPELDKVTGFRDRCLLELFYSSGLRISEITALNRADIDFQSHLLHIRGKGKKERIVPMTKVAVQWLQDYLNHPDRASVEQDHQACFLNRFGKRLSTRSIDRKFQQYLLKTGLSGSITPHTIRHTIATHWLERGMDLKTIQLLLGHTSLETTTIYTHVSMKLKKQIHDETHPHNLEE
The following text describes a protein:
Function:
Efflux carrier for plant-derived alkaloids, antibiotics, heavy metal and other toxic compounds. Involved in cadmium detoxification. Requires probably a proton-motive force for the efflux.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEEPFLLRDELLVPSQVTWHTNPLTVELKRVSRLAAPMATVTIAQYLLPVISVMVAGHNGELQLSGVALANSFTNVTGFSIMCGLVGALETLCGQAYGAKQYEKIGTYAYSAIASNIPICFLISILWLYIEKILISLGQDPEISRIAGSYAFWLIPALFGQAIVIPLSRFLLTQGLVIPLLFTAVTTLLFHVLVCWTLVFLFGLGCNGPAMATSVSFWFYAVILSCYVRFSSSCEKTRGFVSRDFVSSIKQFFQYGIPSAAMICLEWWLFEILILCSGLLPNPKLETSVLSICLTIETLHYVISAGVAAAVSTRVSNNLGAGNPQVARVSVLAGLCLWIVESAFFSILLFTCRNIIGYAFSNSKEVLDYVADLTPLLCLSFILDGFTAVLNGVARGSGWQHIGAWNNTVSYYLVGAPVGIYLAFSRELNGKGLWCGVVVGSTVQATILAIVTASINWKEQAEKARKRIVSTENRLA
The following text describes a protein:
Function:
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
Subcellular Localization:
Cytoplasm.
Sequence:
MSITGIIVSSGIAFGKALHLNHCENHLDYRPIPLSRIPLQQSKFLKALQALKQQLSLSQAKLDPESENYQLIEADLLLLDDDELIEQVKEAIRTLQLSASVAVERIFAHQANELESLDDPYLANRAQDVRCLGQRIVTAINGRLEQGLADLSEATILLAQDLTPAEFALLPKEHISGIVLKTGGLTSHTAILARAAGIPAMLSCQFDAEFIPNNTPLVLDALSGVLYVNPEPEQQARLTVTLHHEQARRQALQTYRDVPAQTQDGHHVGLLANVGNLNEITHVKDEGADGIGLFRTEFMLMNTSTLPDEKAQYNLYCEALHALDGKTFTIRTLDIGADKELPCLCQNIEDNPALGQRGVRYTLAHPELFKTQLRAILRAANHGPIRLMFPMVNQVEELDEIFKLIAECQDALEEEEKGYGELSYGIVVETPAAVLNLASMLPRLDFVSIGTNDLTQYAMAADRTNPQLTKDYPSLSPAILHLINMTITQAKATGVTVSLCGELASSPQMAPLLVGMGLDELSVNLSSLLEVKAAICQGELAKFSELAHTAMQQNRISDLQQCITNYK
The following text describes a protein:
Function:
Elongator complex-associated factor that is not a structural subunit but rather transiently contacts the complex. Regulates elongator complex gamma-toxin target (TOT) activity, resulting in G1 block by Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin), probably through regulation of the ELP1/IKI3 subunit phosphorylation state. Required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA.
Miscellaneous:
MISCELLANEOUS: Present with 5260 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPLVLFTGYPCSGKTTLAKHLVQLLQSKIDATPSLSKYSITYHSDESLGIKHSDYITSQDERKLRSEIISAVKRDLSKNKIVIVDSLNYIKGFRYQLHCEVKNLSTTFCVIQTLCPPETIFEWNKTSNPNPWEPELLNQLIQRYEEPNSSNRWDSPLFAILTPQDNITDYIDDICKVVFQTSKSAKNSGHNDPLSKGLQKPNSATVLKPASQSNFIQVLDIETSKIIKTIMNHIKSLTSIGGVSNGTRVIVSEGITDINDDGCFFVDLPIGNVVTLAQLQRLKRQFINFNKLRDIDQDRIGPLFADYLNKNLN
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Sequence:
MPLNLDIKKKLNSRIGKVKCVDIHESENWILASLYSGKLVIFDYVNQNTIKNIEVSVFPIRCAKFIEKKQWIICGGDDMTIRVYNYNTFEKIKSFEDHTDYIRYIEVHQTLPYILTSSDDMTIKLYDYENNFEKLCSFENHIHYVMMCKFNPKDTYIFASASLDKTIKIWGVQNNTSVVTKPHFTLSGHTKGVNCIDYSCSGETSYIISGSDDKTIRIWDYHTKQCIQVLSGHTQNISCVIYHSNLPIILSSSEDCNVKIWNSSMFKLESTLNYNMDRCWSLCAKKTKNDLCIGYDEGLVVIQIGSDVPIYTMFKNKIIYIKNTDIFIINLQNVQEENYNDGDIYKVNKKELGNCDFYPTNVSFHPSGRFICVNGHHEFNIYTSQVLRNKAYGKSSFFVWSHTGDYAIKDEGNKVSIYKDFTSHHIFQTPYTITQLFGGYLLGVKSNNFICFYDWSDYSLIRKIDINVKNVFWNDSGTYVAISTEDSIYILNYLNSDGNLSKDNINKNNDTINNNNNSNNNGNIELIGVQNRNINHPQHVENKMDEENYFQLESEINESIESGIWIYDSFLYISKNLRLYIYTKKFIDIYAYIDKYLYICGYVYEYDRIFLLDKNFNFYSFFLPITYLQYQKYIMGQDFIAADNIMKNIPESLYNKLSLFLEKMGYKNKALNICNDLEKKFELSLSIGNLQLCVDIINELERKENDSFVHNKYKKLGDTALVYNDIPMAIYCYKKTNDFSSLLIILSTLGDKIGIEELGQMCLNHQKFNIAFICYFLLHKINKCIHILLSNNNFAYAAFFSRVYKPSLLPTILKKWKEHLNKVYPNIPVNLLNPEENPEYFPDYDKAVECEKIFDKVNTIGSTKNYNTLKTLIDLNIVEEIKEIGYDKVEDIFIKQFNEELEKDIQNFDQNGKIFLTEESKNKNVNQKEDNKEINKENNKDDNKENNKEDNKEYNKEDDKEDDKEDDKEDDKFCKMEDTELLSNIQIQEDNKNINSYSINSNQSMDEELL
The following text describes a protein:
Function:
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.
Sequence:
MRENSIIVGLDIGTTKITTVIGEVAPDGTIDIIGEGSVPSEGMKRGSVINLERATQAIKQSLHAAERVSGVRAWNVFVSVGGNHTKAMTSHGLAAIRRQQEISPPDVERAIENARAVPLDPSLEILHTIPQEYVVDGQEGIKNPVGMHGVRLEVDVHIVAGSAGPLLNLRRCVQEAGLQIEGFVLHSLASGLATLDHSEQNQTTVVVDMGGGTTDIGVFKRGNLAHSASIPIGGDHVTADLAQILKIPMEEAEKVKRHYGAAIPELADQELTLEITTASGATHAISAYELSRVIRPRVSEIYGLIRDEIDQALGPVELVAQSVVLTGGGAQLPGAVDLARERFRLPTRLGRPRGIHGLSDIVGDPAHACSVGMVLYGITQDGRVPSGLDDGGDPAGYTEYAGRHDQGYPQGGYPAPGYLTAPTGGTHVAPQGTPGSYPGPGYVVSGGQSQGQPYPPMPNTGSHSAGVPSMSGPVIGGQVVGVDPHAQVLVDGQPQRPPSGPKVSLMDRVRSLFRDWF
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MWTIPELNNSLRPVLFNNESDVIVTDHVGLYENKQKVPNFQNGRIYLTSERLIYVDKDSPKKFTISIPLKAVSEVEHSGGFYLKTSPKITCFLKPEETSSSKDSGHHAVDTTWICTICFMSNTLKSWREGNEIPKCSMCGVKPSIDIIDNAVKATKDSSKMTKKKATVETNECPRCTFKNHPSMLNCEMCGAVIKAIQAQTVRCLIPNNSPVVAFRLSFRKGGDKLFLEKLTSCINKEAVSRTSEGSRDSKENSRDASVTPGLSGLQLSGQQRLSANDSLMESALVDLQALMTQGKQVLTLAKSFQSLIEAEGGTSTTITVSSSFDAADSLSEDVFYQELSRDLSEFLHSGVLDKEGGIISLFDLYALYNRSRGYSLVSPNDLYKACAQMESLGLPVKMRRYKNGFLAVQEKFKTNDALTKQLISWIKTVDASNTKGVSTLGVCSKFKWSVGVAEEELQYAEEKGLLCRDEHVTGLRYFVNIMCT
The following text describes a protein:
Function:
Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with acetylated chromatin.
Domain:
The 2 bromo domains mediate specific binding to acetylated histones. The exact combination of modified histone tails required to recruit brd4 to target genes is still unclear. The first bromo domain has high affinity for acetylated histone H4 tail, whereas the second bromo domain recognizes multiply acetylated marks in histone H3 (By similarity).
Sequence:
MGDGLDAVQMSGSSSSQGQPSSQAPSSFNPNPPETSNPTRPKRQTNQLQYLLKVVLKSLWKHQFAWPFHAPVDAVKLNLPDYYKIIKNPMDMGTIKKRLESAFYTSAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKVFLTKISEMPQQEVEISTTAGKGRGRGRRDPDMNMKVGPVLEPLTASPQTRGLSNLTPGPQTRGPPQGPPTLPPQPIVQIQALPPRVPPSLPTIPLHAPQLGPPFSLGPTDCNPPAPIITAVPPPTQTALPPVHIQQSAAPPILQTPISIPNKRKSQKRKADTTTPTANDQLNESSPAESKSGKTLPRRDNTRPSKLPKKEAPDSQHHWTAAPGTPSPKQQEQLRYCSGIVKDMFAKKHAAYAWPFYKPVDVDTLGLHDYHDIIKHPMDLSTIKDKLETRQYREAQEFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEMLAPAPAPVLHPAPVKTQPVMATASSSDTSSDSSSESESSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQASKPKKKEKEKKEKKKDKHKKKAGVMPALEEILEPPPALKPQGKPKNKDPLPKKSKKLSKKEGGKSNRSMAPPGAAPPTLQPVPGLDTEEDLGLTGGAAMAGMAAGEKCKPMSYEEKRQLSLDINKLPGDKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVSSCLRKKKKPAVPEKSMEAISAVKTKGTSSDSGSSSESSSSESEDSETGMASKPKKRGRGEGKKAHHQTTAPGMPLPQVPLQPQTPALQPSIQLKQQQPQHPSPAAYMPPPVTALEPSQLLENPFDPLAHFMHLPHHANDSSSPAPPHLNAHPPGGPVSPETHPFLNQHPILPSPALHNALPQQPSRPSNRAAPLPPKPLQQSTSQQQPPPQQTLVPPQQLQPQQQQPAPPQQQHLPHHPLHAPQQMRPRPLSPPTLTPQGLLSSQPPQMLLEDDEEPVPSMSLPMYLQHLQPNRLQATPTSLMQSLQSRPQPPGQPSLLQSVQVQSHLPPPQLPVQTQVQPQQPAPHQPSPQLSQHQARHMQQLGFPQGPLQTAQTQPGQHKVSMPSTKAQQIIQQQQATQHHSPRQHKADSYNSAHLRDNPSPLMMHSPQIPQYSLVHQSPSQDKKEPQRGPSALGGIKEEKLPPSPVMRGEPFSPAMRPESHKHPDSKPTMPGHSQQRADMKPLEMSRPVIRSSEQSGPPPSMQDKEKFKQEPKTPSAPKKVQDVKFKNMGSWASLAQKSSTTPSSGLKSSSDSFEQFRRAAREKEEREKALKAQVEQAEKDRLRKEQEKLRGRDEEDSIEPPRRPLEEPRRRQEPQQVQPPPQQHQTQAQAQTLNPAQSPSASQPTQAPPQSPASSQSALDQQREMARRREQERRRREAMAATIDMNFQSDLMAIFEENLF
The following text describes a protein:
Function:
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MNQTAINRADVRTRFIFDDMPVRGLHVRLENVWQHIVKQKNYPAAIRRALGELLAAGVLLSGNLKNEGTLIVQVQGRGRLKMLVAEAASDRTVRATARWDETAEIADDESLGDLLGEGGVFVLTLQPKDGEPWQGVVPLEGGGIAQMLVNYMKRSEQLDTHIVLSASDEAAGGLLVQRLPEEVLDEEAWEHVSTLARTLTAEELAGLDAQHVLYRLFHETPPRVFEPETFEFSCTCSRGKVSDMLLMLGGEEVGGVVVEQGSIEVDCDFCHSKYVFDETDVNALFGEDVVGVAKGLPRHTVQ
The following text describes a protein:
Function:
May act as a component of the auxin efflux carrier.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MITGSAVYQVVEAMAPLYTAAALGYASVRWLKAFSEEQCAGINRFVATYAMPALIFDMVSTNDPYAMNGRLVAADTLQKGFMLLGLVAWAAWSSPRRRDTSAGNGKVAASPLQWVVTAFSMAQLPSTIVMGVPLLGALYGPTSKDLMKQIVVMQLCVWYNVVIFMYEYMAAKDGSTKVGPAPASPENVESTEVQAAQQGMAAASQTTSTAVVGEASPTHGADAEVAEAEDVALPPPPSMSHVAFVTGKKVLKIPNTYATFLGLFWALIAFKCRIKMPKIIVDSLFTIQTTTVGLSMFSSGTFMARQPRFIPCGYVIALVSMILKFLIGPMAMLLASFAIGMQGTLLRIAVIQAALPLSVISFVYAKEYKVHADIMSTGVILGIFILLPVTIVYYILLEL
The following text describes a protein:
Function:
Probable transcription factor involved in muscle spindle development.
Subcellular Localization:
Nucleus.
Sequence:
MTGKLLDKLQVNMTSLLPDSLYPEEGQDLSGSLAIYPGGNDQHYPVMSTDNVIDLGLNNDKNSQDLSYNGTFQPGNKTVTYLGKFSFDSPSSWCQENIISLMSSGILGVQTSQAPNGGGTGNGGGNGGLMGQNQNDVESMFHGLPSYAGCGDLYHEQVGFQGGGMAPYTSQDYSSAKQSLDSGVFPMIPDYNLFHHNTEMPPVDQKPFQNMEAIRVNPPPITPLETIKAFKEKQVLPSFGGMGHQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACDFCGRKFARSDERKRHAKIHLKQKDKKGGDKAVCSPSVGGAPVVTTCA
The following text describes a protein:
Function:
Involved dehydration tolerance. Involved in the adaptive response of vascular plants to withstand water deficit. May possess chaperone-like activity under water deficit (By similarity).
Sequence:
MQSAKQKISDMASTAKEKMVICQAKADEKAERAMARTKEEKEIAHQRRKAKEAEANMDMHMAKAAHAEDKLMAKQSHYHVTDHGPHVPQQAPVPAPAPVMGHGYGHNPTGVTSVPPQTYHPTYPPTGHHNHHHY
The following text describes a protein:
Function:
Common component of the spliceosome and rRNA processing machinery; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPDARAVPLASEAQSKRIYELVDLAKNSRSISRGMNEVTKALNKGKARLVVLSADALPLELVLHLPEVCEDKGIAYIFVPSRQELGRSVGISRQAVAVAIKAPRQGTALDDKLNIFLTELGH