lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.
Sequence:
MRKFLNLVPALMLLAAPCYAQGVVMVAGGGSEGDIGDTASWSYRLYPTLIEAGDVNGDGRVTVAVIADSSQSEFIPEYFEWLGADDAFNVLVATRTQANDPAAVDRVRDVDAIFIKGGDQGKYYDNWNDTRLEDHIRYVVQTLGGGVGGTSAGAMSQSQYALAGEKDLISQDVLTNAQTRYLDDADGGSGIHADFLGFVANTVIDSHFNDRGRLARLLGVMAKVNEDFGLTTGLLGIGLGDLTGLVIRGDRAEVIGQGSVSFLQATPETVTHRPGGAPLYMTNVRADVLTEGWSFNLSGRAVAAQPAGVVTVSYAGDSAANRGALTIQGSKKGNERLYALKPTYFPQSYGLVPTTASTYIFNSLGLNDAQNPDNRGAIQETALRALYDYPHYTGILLSVGAKLSRTQSSPDAIAFGAGTGGSEAAAIVLDGKKIEARGLSPYAAPTDSGNGSLRAAALVNLRVHILGQTGIWGTRYNTRTHTLQQ
The following text describes a protein:
Function:
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Sequence:
MNKTKRIEILTRLREQNPHPTTELQYNSPFELLIAVILSAQATDKGVNKATEKLFPVANTPQAILDLGLDGLKSYIKTIGLFNSKAENIIKTCRDLIEKHNGEVPENREALEALAGVGRKTANVVLNTAFGHPTIAVDTHIFRVCNRTNFAAGKDVVKVEEKLLKVVPNEFKVDVHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEKVEF
The following text describes a protein:
Function:
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Miscellaneous:
MISCELLANEOUS: Present with 5350 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane. Note=Bound to the mitochondrial inner membrane with its active site facing the cytosolic side.
Sequence:
MLLPLTKLKPRAKVAVVGGGVSGLCFTYFLSKLRPDVEITLFESQNRTGGWIYSCNTRDMSGNPIMLEKGPRTLRGVSDGTVLIMDTLKDLGKEAVIQSIDKGCIADKKFLLDPSDKLVQVPNSISTTVKFLLNPLGKGLITGMMGEWFRKKSPHPGQDESVESICDRRFGNNYISNNMISALLRGIYGDDVSLLSAKRTFKKIYYNELKHGSNTQAMIDNMRGKSRSKKTENLHQSLTGCLNDYSNAFGKDRSKLLDLSNTLKKYPMLGLAGGLETFPKIVRNALNEFKNVKIVTGNPVTQIMKRPANETTIGLKAKSGDQYETFDHLRLTITPPKIAKLLPKDQNSLSKLLDEIQSNTIILVNYYLPNKDVIDADLQGFGYLVPKSNKNPGKLLGVIFDSVIERNFKPLFDKLSTNPNALNKYTKVTAMIGGCMLNEHGVPVVPSREVTINAVKDALNNHLGISNKDLEAGQWEFTIADRCLPRFHVGYDAWQERAERKLQESYGQTVSVGGMGFSRSPGVPDVIVDGFNDALQLSK
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MASLGTTVEPVAQNMTEQVASEEPEEQKEGASLESLEAAIEILSTEVLAAFLPEMDEAKEKINELTQNQGILIETMQQENAKFAESQEAKALAEILSQVRAYHIKLNKIKHEMSSINERVARLKRRAQKLKSQKEKEEKSKLEAQQRELELERELTAKIATEPK
The following text describes a protein:
Function:
Serine/threonine kinase regulating cell substrate adhesion, phagocytosis, motility, chemotaxis, and actin cytoskeleton organization. It is a downstream component of Rap1-regulated adhesion, and it is a regulator of myosin II phosphorylation. It is also a negative regulator of development initiation.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Domain:
The N-terminal domain (region 81-193 aa) interacts with PI(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) and PI(4)P (phosphatidylinositol 4-phosphate), and it is the responsible for the recruitment of phg2 to the plasma membrane.
Sequence:
MDDQQPLQTYNQPPPPLPKHIQLQIQQRQLQLQQQEEQERLQQQQQQQQQQQDQQQHKLEEGSRRRSLSDVVGGVNISNKETPKRAFRIYWANDNHMYWTLLLDSTNTVGDVSEGLKDKVPSSGTQCYLYKRTKANFGRWKDRRLSNEDSVWDIVDRRRKNHKSDPIFVLKRKKSTFSISQKKSPQNESDTSPLSSSGEFLNPYTNPTGSNNIVPSNAGHSRNTSSNSNNSANTSSNNLLAHHQFNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNSSNSNSNNSSNTTTTTTTTTTTTTTSTSTNSINTSNNNNNNNSGSNINPSSFISPMSSLVSLSLSSSPASSAPHSPTLSSQPSSPHTITPITTSPPPPQRNNSSKSLKSTMEMEPPAEYISLLSNNPPPTNGSGSRPPSGSFIPGSIVNGSRSSASDLIGFKPPVCQQQQQQQQQQQQQQQQQVQQQQQQPQQVQQLQQLQQLQQQYQQQQPQQQIQPLSPQQQSQQQQQSPVKQSESIPQSPNLQSITQSSSSNKPLSGSTGMNRSSSPSPFAKKNIGGGGGGGSLADRKNRLSVQPKDIMRLMRFYFGDSLDGTFFTIAVQNDTSAKDVCASVEQKLLLPSGSTFVSLVLPIQPNGSKIERVLGEDEIIIEVKDTWEDPSQTFFQVTHKQQAPNNKRLSRQIQAEPHVIPSEWRRSTDAISLRASSDDMWKRKSIPIFLQVTGPPNTHSHSHSPQRQLPNMSGSPHSHHHHQNNNNNNNNNNNNNNNNDLDDDDSDDESDFDVSTLRGWVHWIPSADLEYIKRIGSGTYSKVYKGKYRDKFVAIKTMRGSNMTTEQIESFKKECDILSTIQSPLLISFYGSCIEESQLSMVVEYCSKGTLHKVLNNPLLDFDWDKWFKWMTEVVEGVRYLHSMNPPMVHRDLKTLNILISSDWTAKLCDFGLTRTMTMTNVSTLGMLRGTMAYTAPEIYDGLLFNTKSDVYSLGVIMWEAIQRCISGVYLRPFHEHPISMDIQIIILTSKNKVRPKISENCPEQLKTLITRCWDENPDKRPNCDEILEILLTMKQAHDENKDEWESIRTKLPKQTIKAVSSSSSNNNNNNNNNNNNNNNNNNNNNNNNNNNNGTNTNSTVNNVVVPSSSNATIVVAPSVSSNSSNINTSMDNKSMSSLSDSPVLPSVGIVSTSSLTGNSNINNNNNNIHDNNNPNNNNSNNSNNTSLDVPPVGVILTRDRRNSIIAVGEVPVIVKPPETPDGTTMVTEVFDFEVPQDSPSLEPLSSNNIISTANILNIGYVNNENNSIIIEGNKSTLNEIGNNNNNNNNNNNNNNNNNNSSNNNSINNNSSNNDENNCINNCINIESNESCIKSNTPEQITLKCVDER
The following text describes a protein:
Function:
Methylates ribosomal protein L11.
Subcellular Localization:
Cytoplasm.
Sequence:
MKYFEFTFHTSPCTETVNDVLAAVLGEAGFESFVESEGGLTAYIQQALCDENTIKNAITEFPLPDTEITYTYVEAEDKDWNEEWEKNFFQPIVIDNRCVIHSTFHKDVPQATYDIVINPQMAFGTGHHETTSLIIGELLDNELKDKSLLDMGCGTSILAILARMRGARPCIAIDIDEWCVRNSIENIELNHVDDIAVSQGDASSLVGKGPFDIIIANINRNILLNDMKQYVACMHPGSELYMSGFYVDDIPFIRREAEKNGLTFVHHKEKNRWAAVKFTY
The following text describes a protein:
Function:
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
Subcellular Localization:
Cytoplasm.
Sequence:
MLTNPSQVIIRNQETLSQHKVLVLNHEADLLPKALLDVASSVDALALDYHHYLHLAPQANNKLRCYFGHQLPHQNKYNTVIVYFPKAKPLAPYLFNLAAQHLVPNGQLLVVGENKGGIKSLVKLLPNYFAAGVKLDNARHSLLFGSSLIDTAPEITLSDWASQYQLSTPQGNITICNLVGVFSEKHLDQGTELLLSHLPTLSGRVLDFGCGAGVIAATLLKAQPTLSLECIDINAMALASCELTLAANGMMAKVYPSDGLAQTSGKFDGIISNPPFHDGLASTTNIAQRFVADSAKQLQSKGIWQIVANRHLPYSDTIAAEFGQLTVPAENNKYKLYYFQQS
The following text describes a protein:
Function:
Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 vertices of the pseudo T=25 capsid. Involved in virus secondary attachment to host cell after initial attachment by the fiber protein. Binds host integrin heterodimer ITGAV-ITGB5 (alphaV-beta5) thereby triggering clathrin-mediated endocytosis of virions. Mediates initial virus attachment to CXADR-negative cells. Binding to integrins ITGAV-ITGB5 also seems to induce macropinocytosis uptake of the virus. As the virus enters the host cell, penton proteins are shed concomitant with virion acidification in the endosome.
Miscellaneous:
MISCELLANEOUS: All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Subcellular Localization:
Virion. Host nucleus. Note=Located at each vertex of the virion. Present in 60 copies per virion.
Domain:
The cell attachment RGD motif is exposed at the virion surface and is involved in binding to the integrin heterodimer ITGAV-ITGB5.
Sequence:
MRRAAMYEEGPPPSYESVVSAAPVAAALGSPFDAPLDPPFVPPRYLRPTGGRNSIRYSELAPLFDTTRVYLVDNKSTDVASLNYQNDHSNFLTTVIQNNDYSPGEASTQTINLDDRSHWGGDLKTILHTNMPNVNEFMFTNKFKARVMVSRLPTKDNQVELKYEWVEFTLPEGNYSETMTIDLMNNAIVEHYLKVGRQNGVLESDIGVKFDTRNFRLGFDPVTGLVMPGVYTNEAFHPDIILLPGCGVDFTHSRLSNLLGIRKRQPFQEGFRITYDDLEGGNIPALLDVDAYQASLKDDTEQGGGGAGGSNSSGSGAEENSNAAAAAMQPVEDMNDHAIRGDTFATRAEEKRAEAEAAAEAAAPAAQPEVEKPQKKPVIKPLTEDSKKRSYNLISNDSTFTQYRSWYLAYNYGDPQTGIRSWTLLCTPDVTCGSEQVYWSLPDMMQDPVTFRSTRQISNFPVVGAELLPVHSKSFYNDQAVYSQLIRQFTSLTHVFNRFPENQILARPPAPTITTVSENVPALTDHGTLPLRNSIGGVQRVTITDARRRTCPYVYKALGIVSPRVLSSRTF
The following text describes a protein:
Function:
Histone acetyltransferase that probably regulates acetylation status of histone H3 during meiosis. Histone acetylation may influence recombination and chromosome segregation.
Miscellaneous:
MISCELLANEOUS: The gain-of-function mutant mcc1 (T-DNA tagging) has elongated rosette leaves, increased stem length elongation, early flowering and reduced fertility and seed number due to defects in meiosis.
Sequence:
MSRFPRRFIDDSSMEDAGISLCPSIHYRPINPNDLDRLEQIHRDIFPIKYESEFFQSVVNGVDIVSWAAVDRSRPDDHSDELIGFVTAKFVLAKDSEIDDLIHYDSSKGEETLIYILTLGVVETYRNRGIAMSLISEVIKYASGLSVCRGVYLHVIAHNNAAICLYKRLMFRCVRRLHGFYLINRHHFDAFLFVYFINGSRTPCSPLEVAMFVVNYMKSGIKSVASKLANKDEKGLKWLFCKDTDCV
The following text describes a protein:
Function:
Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD. May have alpha 1,2-mannosidase activity.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MASLLLCHMIYLSTHLFSFPFTCSLFVCWFIACNQQEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDTLDTLVVLNKTKEFEDAVKKVIRDVNLDNDIVVSVFETNIRVLGGLLGGHSVAIMLKEKGEVMQWYSGELLHMAKLLGYKLLPAFNTTSGLPYPRVNLKFGVRSPEARTGTETDTCTACAGTLILEFAALSRFTGASIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDSLLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFTEKEDLTFDIEDYIFTTEAHLLPLWLSTTNQTAPRKNITTEYTELDDSNFDWTCPNTQILFPNDPMYAQSIREPLKNVVDKSCPRSISRVEESLGNGPKPPLRARDFMASNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSLDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGMDLSKHKSGTRGFVAVSKPYNGCSEITNPESLKEKIALMQRGQCMFAEKARNIQKAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKNTEDITIPMLFLFNKEGSIILDAIQEYEAVEVLLSDKAKDRDLEMESMDQKSSDNDSHNQRSEEISTDLNLVPQDPEEGGLSSHAELDSSRVSLSDEDSCIPKLQETSSTNSPVSELDNPLEEQSKTETDSSPSNSWDNKGQSMDSILADWNEDIEAFEMMEKDEL
The following text describes a protein:
Function:
Catalyzes the decarboxylation of the cysteine moiety of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine and this reaction forms part of the biosynthesis of coenzyme A.
Sequence:
MIPAQDHTPDQENSPGQDLDSCFTGQILLSSQKATRSRMEPEAPCPASIPSVERKFHVLVGVTGSVAALKLPLLVSKLLDIPGLEVTVVTTERAKHFYSPQDVPVTLYSDADEWEMWKRRSDPVLHIDLRRWADLMVVAPLDANTLGKVASGICDNLLTCVIRAWDLNKPLLFCPAMNTAMWEHPLTAQQVGQLKAFGYVEIPCVSKKLVCGDQGLGAMAEVEIIVAKVKDVLFQHGGIQQS
The following text describes a protein:
Function:
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to form 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipooligosaccharide (LOS) to the outer membrane of the cell. Can functionally complement lpxH deficiency in E.coli. Overexpression of LpxG results in toxic accumulation of lipid X and profoundly reduces the infectivity of C.trachomatis. Can utilize UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine as substrate in vitro, but the substrate is likely UDP-2-N-((3R)-3-hydroxyicosanoyl),3-O-(tetradecanoyl)-alpha-D-glucosamine in vivo.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein; Cytoplasmic side.
Sequence:
MFVSVGITASLTTILAAPVLTWVWANHLEPNLLRVTRLNWNLPKKFAHLHGLRIVQISDLHLNHSTPDAFLKKVSRKISSLSPDILVFTGDFVCRAKVETPERLKHFLCSLHAPLGCFACLGNHDYATYVSRDIHGKINTISAMNSRPLKRAFTSVYQSLFASSRNEFADTLNPQIPNPHLVSILRNTPFQLLHNQSATLSDTINIVGLGDFFAKQFDPKKAFTDYNPTLPGIILSHNPDTIHHLQDYPGDVVFSGHSHGPQISLPWPKFANTITNKLSGLENPELARGLFSFPEESRLLYVNRGLGGWKRIRFCSPPEICLMRCLYEP
The following text describes a protein:
Function:
Heterogeneous nuclear ribonucleoprotein (hnRNP)-like protein that acts as a component of a complex regulating the turnover of mRNAs in the nucleus. Binds with high affinity to RNA molecules that contain U-rich sequences in 3'-UTRs. May function in complex with UBP1 and contribute to the stabilization of mRNAs in the nucleus (By similarity).
Miscellaneous:
MISCELLANEOUS: Plants over-expressing UB2A1 display severe growth defects consisting of premature cell death and chlorosis.
Subcellular Localization:
Nucleus. Note=Relocalizes into nuclear speckles in response to abscisic acid (ABA).
Sequence:
MTKKRKLESESNETSEPTEKQQQQCEKEDPEIRNVDNQRDDDEQVVEQDTLKEMHEEEAKGEDNIEAETSSGSGNQGNEDDDEEEPIEDLLEPFSKDQLLILLKEAAERHRDVANRIRIVADEDLVHRKIFVHGLGWDTKADSLIDAFKQYGEIEDCKCVVDKVSGQSKGYGFILFKSRSGARNALKQPQKKIGTRMTACQLASIGPVQGNPVVAPAQHFNPENVQRKIYVSNVSADIDPQKLLEFFSRFGEIEEGPLGLDKATGRPKGFALFVYRSLESAKKALEEPHKTFEGHVLHCHKANDGPKQVKQHQHNHNSHNQNSRYQRNDNNGYGAPGGHGHFIAGNNQAVQAFNPAIGQALTALLASQGAGLGLNQAFGQALLGTLGTASPGAVGGMPSGYGTQANISPGVYPGYGAQAGYQGGYQTQQPGQGGAGRGQHGAGYGGPYMGR
The following text describes a protein:
Function:
Histone methyltransferase.
Subcellular Localization:
Nucleus.
Sequence:
MPASRLPLKRCTAAVPREGEPPAAEGMAPAKRRRERVVPSRFKDAAVSTTAPPKKACKAVVATEDGDGEVYEVEVRAASPKAASFGAVRTVVWTGEEQPAQTEEELYRACRNISRSSTSGCFSGSVVTSVSNAGGNDGLEKRPVVGSVVTSVSNAGGNGGIEKRPVVGSAVTSVSNAGGNGVPETRPVVVECKPKRESGVRREDFYWPEDFVLGDVVWARAGKKCPAWPALVIDPLLHAPEVVLNSCIPGAICVMFFGHSAGGHGRDYGWVKQGMLFPFVEYMDRFQGQPLYKLKPSKFRAAIEEAFLAERGFFELQIDEGCSLEKAANDQSVADGINEVTGSNNEQECQSDSQVVGKSAACCESCGNRLTSKISKKKKQEVEQLLCRHCEKLLQSKQYCGICKKIWHHTDGGNWVCCDECEIWVHVECDRTCSDLEDLENTEYFCPDCKSKRKRVLRAEHTNMPNSSEFPDKTSKEKLPESIPVCCFGMEALYIPEKHMILCQCKSCKERMMSLNEWERHTGSRKKNWKMSIKLKSTGEPLIGMLDDIPGGNFKSSTPSIKKEELLTLQANSYSPVYAKWTTERCAVCRWVEDWDYNKIIICNRCQIAVHQECYGARVVQDFTNWVCRACEVPQQKRQCCLCPVKGGALKPTEIDQLWVHITCAWYQPKVSFPFEETMEPATGILNIPSEYFKRTCVICKQMHGACTQCYKCSTFYHTMCASRAGYCMELQYTERNGSQVTKMVSYCAFHSTPNPDNVLIVKTPEGVFSTKLLNQNNEKQSPARLDKENHQAFPAKNSDCPAVRCLPYEMLKNKKEQGEAIPHRITGPQHHSQDLIEGLNSYMDQNGDQTFSTFKERLHFLQKTENKRVSCGRSGVHGWGLFAARKIQEGQMVIEYRGDQVRQSVADLREARYHRENKDCYLFKISEDVVIDATERGNIARLINHSCMPNCYARIVSVGDDKSQIILIAKRDVSAGEELTYDYKFDRDESEDRKVLCLCKAPNCRGYMN
The following text describes a protein:
Function:
Cooperates with Rab11 and fwd/PI4K to mediate the flow of membrane through the Golgi, which is required to support cleavage furrow ingression, therefore promoting cytokinesis in male meiotic cells.
Subcellular Localization:
Cytoplasm. Golgi apparatus. Note=Specific to spermatocytes.
Sequence:
MRAAVGLMLSHGAGGMEPALSRPDYEQSALHHSCLLVLLRGVGPSRARVLQRAFEKVRRVNHIRVNDSSGHPRSIWIRFVHDHPVEHNDWGDFQTHRRLLGLVTIGKFDSQIELNELCRQHESLKVRYGSTLYESRAIFFGPDEQPLETIGEVLGPPAAGGRRLQDEFTTPSNFKAQAFFYREQDSCADLESRIGDFASALFWVLESRRLERSREKADKVSLLLAPFEKRDFVGLDMESRNNRKRCVGRVMKNLADLSLQAGLVDDALSLYHNANETLRSVGDSLWVGATEEGLCAASAMLLYPQMRETETLHRNSSLQEAGTSPLKNTPEKWRASDATKKISASDATANNVDSNQPQQRVTSNSSSCSSVSSLVTTATNSSASDTPTTSSSSTSTISAAPIPGHQRNGDLPGNILKAEEISNYYRKAIINYSKYRHAATIETEAALKASRICIEQNRPLDVAMFLQNILYINLSMSEAERVKRFEVITDLYQQIGYQRKAAFFQRLAALKHVQQGSQAPDWNQSYRLMLGSFTGYRLCLDPLEVIENAAGWPALQIDLVQTLITAARRLGHSALATRHMTFLLQTQWDNMSPTEQSEMAVQLQNLSAQCEGSPVPLVLENGTVIPPANLTDLPYCIDLQVKDLPAHLRPQRIKVAKADSGPFLFTPIHFNSVDRRDKKKDKNKIAFQWVQNDLSEVTVRLRNPLPFELPVTDMRLLTNGVVFESLPQTLVLQPHVPTYVALHGTPIETGQLDLQGYSTHTLGVKSNCRLKHMRGRSFPPNYVVDVIPALPRISVKTSLPQTATFSNMNSADIVVTSASLTLYNGESSSCTITITNESATLPLEHLEFSINSNVEQELQQKIFRIDEEAIKAHLPVPPQGTIEIIVDVFAEADFVCPQPPASLHSAAAPGDYGASSLTHYSSVSTSGHASLPSRVGSPHHRRNEPQNSSFRSTISGGPPSLAALTLHPGGGGGVGPSSLGSQYNQHIEAQVRFKYSGGDALTAGYCRQCAVSFNLELLPSVQITSWDVLPAEVASQFYLVLDISNLTAQEMSLNYTDTKNILIEAKESCRVPIPVDRCSLEKVVAARAAEVAENLERELCFRTQLLSFNDALSKLCSIHIAERVKIKWLLTGTDIQGIASLRGIVLSQSMVDLTAVSPLEWAISFQDTLVQPHNEIVCTVGQRSLLSIQLANQSLQPLRNLVLSIKFYQDYLNGMENYNLETRVAISGPNRIAIPLLEKQEQKEHTCSVIFFTPGRFKASIECTSNPQKQSEQPSSLLTRSCPAEAESVGQSVMFSSSYDEQQAHVWKFIPPIEVTVVEQ
The following text describes a protein:
Function:
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaB is not essential for flagellar synthesis and motility.
Subcellular Localization:
Secreted. Bacterial flagellum.
Sequence:
MAINVSTNVSAMTAQRYLNNAADGTQKSMERLSSGYKINSARDDAAGLQISNRLTSQSRGLDMAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSANGSNSSSERQAIQEEVSALNDELNRIAETTSFGGNKLLNGSFGNKSFQIGADSGEAVMLSMSDMRSDTKAMGGKSYVATNGKAPDWSVTNATDLTLSYTDKQGEAREVTINAKAGDDLEEVATYINGQNGDIKASVGDEGKLQLFAANQKVSSDVTIGGGLGTEIGFAAGKDVTVKDINVTTVGGSQEAVALIDGALKAVDSQRASLGAFQNRFGHAISNLDNINENVNASRSRIKDTDYARETTQMTKSQILQQASTSVLAQAKQSPSAALSLLG
The following text describes a protein:
Function:
Polyprenyl transferase; part of the gene cluster that mediates the biosynthesis of pyripyropene A, a specific human acyl-coenzyme A:cholesterol acyltransferase 2 inhibitor. The first step of the pathway is the synthesis of nicotinyl-CoA from nicotinic acid by the nicotinic acid-CoA ligase pyr1. Nicotinyl-CoA is then a substrate of polyketide synthase pyr2 to produce 4-hydroxy-6-(3-pyridinyl)-2H-pyran-2-one (HPPO) which is further prenylated by the polyprenyl transferase pyr6 to yield farnesyl-HPPO. The next steps consist of an epoxidation of farnesyl-HPPO to epoxyfarnesyl-HPPO by FAD-dependent monooxygenase pyr5 and a cyclization of the terpenoid portion by the terpene cyclase pyr4 to yield deacetyl-pyripyropene E. The 2 cytochrome P450 monooxygenases pyr3 and pyr9, and the 2 acetyltransferases pyr7 and pyr8 are involved in the conversion of deacetyl-pyripyropene E into pyripyropene A through several cycles of oxidation and acetylation steps. Pyr7 acetylates deacetyl-pyripyropene E to pyripyropene E which is oxidized to 11-deacetyl-pyripyropene O by pyr3, which is in turn acetylated into pyripyropene O by pyr8. Pyripyropene O is then oxidized to deacetyl-pyripyropene A by pyr9. Deacetyl-pyripyropene A is finally acetylated to pyripyropene A by pyr8.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MATAQSPTQLVRTLIDVSRFDKYNCLFAIFPGVWSIFLAAASRHADGVHLPSDWVLGRAGLAFAYTYLLSGAGMVWNDWIDRDIDAQVARTKNRPLASGRLATRAAIIWMLVQYAASVWLMDRMLSGQNLWTFMLPLTTGIILYPFGKRPTTRKLGIYPQYILGASSALTILPAWASVYGDSVAPPDLLAKCLPLCVFLFLWTIYFNTAYSYQDVKDDCRLSVNSSYVLAGQYVHGLLLLQAVAVVMVIPWILHENGSAWLWFSWLGVWTAALAEQLYLFDTKDPSTGGRVHRRNFALGIWNVLACFVELLLVSGSLDMF
The following text describes a protein:
Function:
Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Postsynaptic density. Synapse. Cytoplasm. Cell projection, axon. Cell projection, dendritic spine. Cell projection, dendrite. Presynapse. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Suppression of neuronal activity induces synaptic accumulation and clustering of DLG4.
Domain:
The PDZ domain 3 mediates interaction with ADR1B; The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic density.
Sequence:
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL
The following text describes a protein:
Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MEAAGTWTLLLALLLLLLLLALARPRTRGHLPPGPPPLPLLGNLLQLRPGALYSGLLRLSKKYGPVFTVYLGPWRRVVVLVGHEAVQEALGGQAEEFSGRGMLATLDGTFGGHGVFFSNGERWRQLRRLTTLALRDLGMGKREGEELIQAEAQRLVEAFQGTEGRPFDPSLLLAQATSNIICSLTFGLRFPYEDKEFQAVVQAASGTVLGVSSPWGQVSRPQGNRSWTPRAPHSDVVDAFLLKMAKEEQDPNTELTDKNLLMTVIYLLFAGTVTVSTTVRYTLLLLLKYPQVQERVREELSRELGAGRAPGLGDRARLPYTDAVLHEAQRLLALVPMGVPRALARTTCFRGYTLPQGTEVFPLLGSVLHDPEIFDEPEEFNPDRFLDADGRFQKQEAFLPFSLGKRICLGEGLAHAELFLLLTTILQAFSLESPSPPGALSLQPAVSGLFNIPPAFQLRVRPH
The following text describes a protein:
Function:
EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
Sequence:
MPFSLFICQSRAQNPNKYQTSPLTARSGTSKTPSREKSHHFEMAVAFPDVKSASGLKKLDEYLLSRSYISGYQPSKDDVTVYEALSKPVSSEYVNVSRWSNHIEALLRVSAVFGEGSGVKLDAVATPPAADAKAADDDDDDDDMDLFGEETEEEKKAAEERAAAVKASAKKKESGKSSVLMDIKPWDDETDMKKLEEAVRSVQMEGLLWGASKLVPVGYGIKKLQIMLTIVDDLVSVDNLIEEYLTVEPINEHVQSCDIVAFNKICKCSFNFVAPAHKLDCANFELFRQTQELVASKMLNSGRCFIEASFIRFLSSPALPRQPNPPLAGHHHHLTTIFESSLCSLLLRCLHYRSPVRLSIRFLYFSFITATLLPGPAELHLERFATLNHGVEFESLNVDSFGAQMPSSLGFIAADF
The following text describes a protein:
Function:
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MRPPRGGGRGGGFRGGRDGGFRGGRDGGGRGRGGFGRGGGGFGRGGGGFGRGGGFRDEGPPSEVVEVSSFMHACEGDAVTKLTNEKVPFFNAPIYLKNMTQIGKVDEIFGPINEAYFSIKMMEGIVATSYSSGDKFYIDPRKLLPLARFLPQPKGQSAGRGGGGGGRGGGRGGRGGGGFRGRGGPRGGRGGPPRGGGFRGRGRS
The following text describes a protein:
Function:
Synthesizes nicotianamine, a polyamine which serves as a sensor for the physiological iron status within the plant, and/or might be involved in the transport of iron.
Sequence:
MDAQNKEVDALVQKITSLHTAIAKLSSLSPSPDVDALFTDLVTACIPPSSMDVTKLGPEVQEMREGIIRLCSEAEGKLEAHYSDMLAAFDNPLDHLGMFPYYSNYINLSKLECELQARYVPGGIAPARVAFIGSGPLSFSSYVLAARRLPDAMFDNYDLCGAANDRASKLFRTDKDVGARMSFHTADVADLTGELTAYYIVFLGALVGMAADDKAKVITHLGAHMTDGAALVVRSAHGACGFLYPIVDPHDIGRGGFEVLVVYHPDDDVVNSVIIAHKSKDVHANECHNGRGGRCARGAVPVVSPPCRFDEMVADVTHKREEFANAKVAF