lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the presentation of foreign antigens to the immune system.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MGAGRAPWVVALLVNLMRPDSFMVEGRDSPEDFVIQAKAECYFTNGTEKVRFLVRFIFNLEEYLHFDSDLGFFVALTELGEVDADQWNKRLDLLETSRAAVNMVCRQEYKLGAPFTVERNDFYPGDISVRWFRNGQEERSGVMSTGLVRNGDWTFQTTVMLEMIPELGDVYSCLVEHPGLLRPVSVAWVAQSEYSWEKILSGAAAFLLGLTVFLVGAVIHLKAQKASVETQPGNEASRALLPPHPY
The following text describes a protein:
Function:
Negatively regulates the expression of the ganSPQAB operon. Inhibits transcription of the operon by binding to an operator in the promoter region. In the presence of galactobiose, GanR dissociates from the promoter, resulting in the expression of the gan operon.
Sequence:
MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEKLNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADGIESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKTVNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFSVENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNISFAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN
The following text describes a protein:
Function:
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
Miscellaneous:
MISCELLANEOUS: The mature protein migrates in two distinct mature proteins, P16 (16KDa) and P17 (17KDa); MISCELLANEOUS: Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and mammals such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig can ovulate in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the number of follicles that go onto ovulate during each reproductive cycle are poorly understood. According to PubMed:21970812, mRNA expression levels of GDF9 and BMP15 are tightly coregulated within each species and influence species-specific ovulation-rates.
Subcellular Localization:
Secreted.
Sequence:
MVLLSILRILFLCELVLFMEHRAQMAEGGQSSIALLAEAPTLPLIEELLEESPGEQPRKPRLLGHSLRYMLELYRRSADSHGHPRENRTIGATMVRLVKPLTNVARPHRGTWHIQILGFPLRPNRGLYQLVRATVVYRHHLQLTRFNLSCHVEPWVQKNPTNHFPSSEGDSSKPSLMSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQKDSGGLELWHGTSSLDIAFLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR
The following text describes a protein:
Function:
Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MEYQILKMSLCLFILLFLTPGILCICPLQCICTERHRHVDCSGRNLTTLPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAHLPRSLWNMSAANNNIKLLDKSDTAYQWNLKYLDVSKNMLEKVVLIKNTLRSLEVLNLSSNKLWTVPTNMPSKLHIVDLSNNSLTQILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLKWMMETKAHVIGTPCSTQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQPKVTKIPKQYRTKETTFGATLSKDTTFTSTDKAFVPYPEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTKSSPTPMTLSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLMLNVVVMLAV
The following text describes a protein:
Function:
Actin-based motor protein, possibly involved in a wide range of motile processes, such as cell movement across a surface, and extension and retraction of pseudopodia or lamellipodia.
Sequence:
MATFKRDLTKNVGVEDLIMLTEVSESSLHENLKIRYKEGLIYTSIGPVLVSMNPYKQLGIYGNDQINLYKGKHEFEIPPHIYSIADKAYRALRSEGENQCIIISGESGAGKTEASKYIMQYIASITGSSTEVERVKKTILESNPLLEAFGNAKTLRNNNSSRFGKYMEIQFNLGGDPEGGKITNYLLEKSRVINQTQGERNFHIFYQLLKGSSEEEKKTYNLLSPDQYHYLTRNASNGCFTADGIDDQIGFKQTKNAMKVVGIDEPLQKEIFATLSAILLLGNLSFNKSASGNGSVISDKKLANTIASLMGVDAIVLESSLVSRQISTGQGARISTYSVPQTVEQAMYARDAFAKATYSKLFDFIVRKINQSIEVKTIGKVIGVLDIYGFEIFENNSFEQFCINYVNETLQQIFIDLTLKTEQEEYVQEGITWIPVQYINNKACVDLIEKKPIGILSLLDEECLFPEGNDQTMIDKLNKHFSNHTHYSKVERQKNSQFIINHYAGKVFYNIDGFLDKNRDTLFNDLVTLATSSSCSLLVEIFKYVPPLEVDPEQEKKNRDKFSKNGFANNAAKTFIPTDKKRPITAGFQFKNQVTSLLKSLYSCSPHYVRCIKPNSNMRALEWDQSKCAEQVAYLGLFENLLVRRAGYCYRQTFSKFMRRYYMIGKSTWPKWSGDAEKGVNLLMGELTQEINIKEEVQYGKTKIFIRNPQPLFLLEDKRNKRLNDLATKIGSVWKMYKQRKWYLRTLAAIKIQRTYRGWLLVRECVKLKNQSISIFQNNKERNRQSIKLSKAAFIGDFLSLTRDNYTTATLKREEGPNAVLQLSLNVSKVSRHHKIQKRSLLVTNETIFTITPHKPKKDGSWFAIKRKVPFSAIEKISFSKLSDDFFVIHIINEHDLCLETNKKTVLITLLSNLYSKHLNGKELVFEFKDSIQYRNQKGPSELKFVKVDSIHEKSSNSPQANSPSFTAKAEKNYLKVCVLPGLSSESKSILIEK
The following text describes a protein:
Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGTPPASPAPPRPAPPPGPPGQEARKEPPGAMDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAECVSVAPVAVESPPEPGAAAFRLDTAQRSHLLAADAPSSAAWVQTLCQNAFPKGSWALAPAENPPKLSALEMLENSLYSPSWEGSQFWVTVQKTEAAERCGLHGSYVLRVEAERLTLLAPGAQRQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKIQGKAGQGQDVLRADSHEGEVADGKLASLAAPLELPGSPPALYSEPLDSLRIPPGPSQDSLYSDPLDSTPARAGEGTQLKKALYWDLCEHVQQKLIKAKLTDPKEDPIYDEPEGLAPATLRGLYDLPQEPKDAWWCQARVKEEGYELPYNPAMDDYAVPPPRSTKPFPAPKPQGLALSESGAATGSGSQGHSSDTALYSQVQKSGASGSWDCGLSGVVTDRTGAKSEGST
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDVFGLENSRELVVSWWPKINDVVHAVSPIWNTSRAFGIHVLRFDTTTDRPTLLELVLSFAITVIRIYMIYIILVTDAWDLIFVSSSQLVEKGLDIVLKIPFAMMLFVPWIFLFRKTKIFYISRDLDIFDALVNETFLCFVRTSCFLFSAIIFLFLQIAKYNYPANYQFFHMFSTLFATAAISIPLLSLASIRGLEFWMDHFFVLTFVGFSWSGGLLYNNICNVLLFHILYRIEVINDFLRKSITSDRLEDDLGSVLQLIKTLMRLHDKLSDISTNCSQCFGFSVGTSVFITMIHVLISQLITTFAFIRVMFYHYNETELNDSIIYTIGTTSYCCLPIITIWIAGHIKKRNVITFKLVHRIINTTNVVEIEDLLQQFSEQMNHRSPSVDFRFFDVDWPLLVKACSEAATYLIIMIQFETKI
The following text describes a protein:
Function:
Riboflavin transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGCSAATFILVALFGSSSWMGTNSVWMQLPLLTSELPEQWNLPSYLAGVVQIACIVPLIYTILHKGVKSFTIPTAPLIIALLSLACCCQLGLSFFWSDYSEIFGAPRSWPLYSLLFGLAIVNAMSNVLFMPFMAQFHPAYLNAYFVGMGLSSLAPSLLSLAQGTSMFKCDEKGVAERFPPNFSVSIFFFVIFSFTCVALFAFIALYRSGAHTHFATPNKKEPNEGTPLKKDLNNTSSSRKGDDEDESPIEIHETGAPAIDAIVSELDVTFREELQKSFRDANYLERSAMINDDSEPHPVDYITGVKFTFLLFTTALVNAQMNGIITSVQSYAALPYSQATYHFAVTLSNVVSPLSSFLPFFISVRSIPVLAILTACSTAMTAFIVYLAALSPNLIFNSVTIGSALSIGGSLIAAGLHSYLRVVFASLLREGHQSESRLFWCGVFIQIGSFIGSAVMFPLVNIAHLFTSAPQCKSIS
The following text describes a protein:
Function:
Transcription factor. Interacts, when in complex with WRKY71, specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Represses specifically gibberellic acid (GA)-induced promoters in aleurone cells, probably by interfering with GAM1.
Subcellular Localization:
Nucleus.
Sequence:
MEEVEVANRAAVESCHRVLSLLSQQQDPALLKSIASETGEACAKFRKVVSILNNDGGGGHARGRFSRGSKPVELMRQKGLLESSSNPPLGMLMSSSTAATPSASAVSSVPQLRAQVGAPQTDLHRLDLVSSSSKSAHQFGAPKMVQPLSVQFQFGAIAHRYPFQQQQKLQAQMFKRSNSGTSLKFDSPSGTGSMSSARSFMSSMSMDGSVASLDRKPPMHLTGGPTASEPLNVHHGARKKRCMGRGHGDKCTVDNGCHCSKKRRKLRIKRSIKVPAISNKISDIPPDEYSWRKYGQKPIKGSPHPRGYYKCSSVRGCPARKHVERCVDEPAMLAVTYEGEHNHNRLPTQSALT
The following text describes a protein:
Function:
Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (By similarity). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (Probable). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (By similarity). May play a role in the regulation of the circadian clock (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The core of the protein consists of three WD40 beta-propeller domains.
Sequence:
MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGKTAVMELFRPKGESKDLLFILTAKYNACILEYKQNGDNIDIITRAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRENKELKAFNIRLEELQVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDSHREMDNMLVLSFVGQTRVLMLNGEEVEETELTGFVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPNGKNISVASCNSNQVVVAVGRALYYLEIRPQELRQINCTEMEHEVACLDITPLGDTNGMSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLSLETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDASGGTTALRPSASTQALSSSVSTSKLFSSSTAPHETSFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFHYSDGKLQSLAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTAEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLSHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGFIDGDLIESFLDISRPKMQEVVANLQIDDGSGMKREATVDDLIKIVEELTRIH
The following text describes a protein:
Function:
Crystallins are the dominant structural components of the vertebrate eye lens.
Sequence:
MSHTSKAAPASHGDKTVPAPVPSAKPTRTGDPMMGSFKIVLFEQENFQGRHVELLNECGNLGERGFDRVRSVIIESGPWVAYEQSNFRGEMFILEKGEYPRWDTWSSSYRSDCFMSARPIRMDNQEHKISLYECTDFKGNKMEIIEDDVPSLWAYGFYDRVGSVRVPCGTWVGYQYPGYRGYQYLFETCDYKHWNEWSAYQPQIQSIRRIRDKQWHQKGCFVIAATK
The following text describes a protein:
Function:
Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPVSMAVCETANVVNAALRESLGGNSSAGSSTDQAKSGEDTNGSLQNHIVANAKRILMAKIEYEEVPNYHESVLENLKSKYIVIKPGNPGAINGFSGKNNTGKLVGANGHDNNGARKQAEHPNNQSHHNHPHPTSNPNELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLADCNVAEPGSGCIICAMAKTLLATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADSLEDAFEGHFSRERLEDMGYKCEGCKKKLKRFSMIGNKLTKQISFKPRIDLSKYAARSPAAQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPITMQNVCNTNAYIMFFELDLSQAASPPANRPNGVRLTNGHSTTPVPAATVSSPSPTRFIGPQLPPGGANGYTNGNAQKTAIQFKQQNQQNGLQLGTGKFQDTAKPPLVGAYAKGEATSAPTANGNKSSSPSSNSSSNHKSINQQQYLPISSDDEDIDDEMKPGPTTAQLPSMPNMTEDNTEPKAKSPVKIHLKTPVKTPLKSLVPYESASEEEEAPLPNPRQSPGGEDFSESDQESGQTNGHSKTNGSLTNGSASSSVHVNNSKQKTDAIDEIFKSLKKSADSEEDDDEEEPSIQLTNGWHPQKQSQSQSKAPPSPKTPPSPAVIKSKTGIWKVTRKDEVDAIDDDDDAVVVEGAPVKIPTPNKTHRNPFSSSKPSTDSPATPGAKRQKLLNGSALKSHQQPRVGNGYQSNVTSNGSTVNELLKQSYRGYGASVLSWNGKPAELEKEPFELVCAKRIAGHGSVEGSDIVEGSVAVDAAVTSSSNSNDVVVIAVALLVDAREQRQRDLDDDEENEMDRGRQRKVKSGSAKGNNASNSTPGYNPFQEYEGQKRWNKNGGGGGFSRFYNQNYRQNFQQRNKFKFNRFGGAGSAKFQQQRALQRHLSAGGGFSRRQPSAQQQQQT
The following text describes a protein:
Function:
In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.
Sequence:
MPKTSPKTTAKADTKAAAPKTAADSKSAATTAAKPVAAKAAGKGDHVFLVDGSSYIFRAYHALPPLNRKSDGLQVNAVLGFCNMLWKLLRDMPADNRPTHLAIVFDKSEVTFRNKIYPEYKAHRPPAPDDLIPQFALIREAVRAFDLPCLEQGGFEADDLIATYAREASDRGATTTIVSSDKDLMQLVNDRITMYDTMKDRRIGIPEVIEKFGVPPEKVVEVQALAGDSTDNVPGVPGIGIKTAAQLIVDYGDLEQLLFRATEIKQPKRREALIENAEKARISRKLVLLDDKVELEVPLDDLAVHEPDARKLIAFLKAMEFSTLTRRVADYSQIDPANVDADVANSSEARGGDSAARTTSSATSGDLFAAPAVTATGGDKGGKSASIKGAPISLAAAREEALRKLPVDRGKYQAIKTLAELNAFIARIHDAGHVAIEIRANSIDPMQADLCGVALSLAPNDACYVPLAHKQSGGGAGLFDGGLAPDQVKHADAIDALRPVLESSGILKIGFDVKFTAVMLAQHGITLRNTDDAQLISYVLDAGRGSHGLESLAERWFGHAMLKEGELLGSGKGKITFDQVPIDKAAPLSAEGADMALRVWRVLKPRLVAEHMTTVYETLERPLVAVLARMERRGISIDRQVLSRLSGDFAQTAARVEAEIQEIAGEPVNVGSPKQIGDILFGKMSLPGGTKTKTGAWSTTAQVLDELAEQGHDLPKKILEWRQVSKLKSTYTDALPEYVNPQTHRVHTTYALAATTTGRLSSNEPNLQNIPVRTEDGRKIRRAFIATPGHKLVSADYSQIELRLLAEIADIPVLKQAFRDGLDIHAMTASEMFGVPIKGMPSEIRRRAKAINFGIIYGISAFGLANQLGIAREEASAYIKKYFERFPGIRAYMDETRDFCRQHGYVTTLFGRKCHYPDIKASNASVRAFNERAAINARLQGTAADIIRRAMTRVEDALAEKKLSAQMLLQVHDELIFEVPDAEVEATLPVVQHVMQDAPFPAVLLSVPLHVDARAAKNWDEAH
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
Sequence:
MKSSETKKKCPYVERDISWMYFNQRILLEAARPEVPLLERLTFLGIYSNNLDEFFRVRVATLNRIIEYADKNIQKEQETATRTLKQISKLHNRFYEQFEETFASIMEELKKENICVIKDTEMTDDQKTFITSFYRNKLNGSTTPLFLNGARPLDDQTDEDIYLAIRLLRKDETGKIKEKDYAVIELPTEEYGRFIQLPDSEGKTYLMFLDDVIRYCLPLIFVGMKYTDYEAYTFKFTKDAEMEIDSDLRTGVLQKISKGVKSRKRGEPIRFVYDEQIPKDLLKRLVDRLNVDKNDTRVAGGRYHNFKDLMKFPVCGRYDLKYPVWEPVFKPELNGKESLLTLIRQKDRSLHYPFHSFDTFIRVLREAAISKEVKSIKMTLYRLAKESKVIKALICAAKNGKKVTVVIELLARFDEASNINWSKRMQDAGIHVIFGVEGLKIHSKLVHIGTRHGDIACISTGNFHEGNARMYTDYTIMTAHRPLVREVNAVFDFIEKPYTPVNFKELLVSPNDMRKRLIALISKEIKNKEQGKEAYILAKVNHITDRALIEKLYEASTAGVQVELVVRGNCSLVTGIAGISENIHINGIIDRYLEHSRIFIFANGGEEKYYIGSADWMPRNLDNRIEVLAPVYDKEIQADLKRIVCYGYRDTAKGRIVDGTGENRPWENRPSTLCKDFTPALAEAETATVVFRSQEELYRKYKNTL
The following text describes a protein:
Function:
Extracellular proteinase found in the pitcher fluid of carnivorous plants. Digest prey for nitrogen uptake.
Sequence:
MSLPLPKVHAIYTSMADSATSSLLVILLLVSPLLCICSSQGSSTNLRVILTHVDAHRDLSPLQMIKRSMQRGKQRHGEFLAGLMVSTQGSSDVRTRVVGGDGEFRMSLSIGTPPVPFLAIMDTGSDLIWTQCKPCKACFKQPTPIFDPAESSSFAKVSCSSPLCKKWKDSKCGSSCEYSNSYGDGTSTEGFLATETFNFGGSDNESSVPDIGFGCGVNNDGPGLNHGAGIVGLGRGPLSLVSQLHTRQFSYCLTSIGGTNGSSSLFIGSAPSSVHISNASTTPLLENPVLPTFYYISLVGISVGRNRLSIPQSWFQLTKDGTGGLIVDSGTTITLLTEDAYDVLRREFLEQTKLELSDSSDNSGLDLCFDLPHGKYAKQIAVPKLIFHFTGLDLALPPENYMIVDEKMGLACLAMAPAGGFSTLGNIQQQNMLVVHNLEQKTMSFVPTDCGKL
The following text describes a protein:
Function:
May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1. Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation. Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA. Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration. Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1.
Subcellular Localization:
Cell junction, focal adhesion. Cell projection, podosome. Note=Localizes to both focal and fibrillar adhesions but is mostly found in fibrillar adhesions.
Sequence:
MEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYDDKVSALMQPSQKRYVQFLSGLLSGSVKMNASPLFLHFVILHGTPNFDTGGVCRPFLKLYQAMQPVYTSGIYNVGPENPSRICIVIEPAQLLKGDVMVKCYHKKYRSATRDVIFRLQFHTGAVQGYGLVFGKEDLDNASKDDRFPDYGKVELVFSATPEKIQGSEHLYNDHGVIVDYNTTDPLIRWDSYENLSADGEVLHTQGPVDGSLYAKVRKKSSSDPGIPGGPQAIPATNSPDHSDHTLSVSSDSGHSTASARTDKTEERLAPGTRRGLSAQEKAELDQLLSGFGLEDPGSSLKEMTDARSKYSGTRHVVPAQVHVNGDAALKDRETDILDDEMPHHDLHSVDSLGTLSSSEGPQSAHLGPFTCHKSSQNSLLSDGFGSNVGEDPQGTLVPDLGLGMDGPYERERTFGSREPKQPQPLLRKPSVSAQMQAYGQSSYSTQTWVRQQQMVVAHQYSFAPDGEARLVSRCPADNPGLVQAQPRVPLTPTRGTSSRVAVQRGVGSGPHPPDTQQPSPSKAFKPRFPGDQVVNGAGPELSTGPSPGSPTLDIDQSIEQLNRLILELDPTFEPIPTHMNALGSQANGSVSPDSVGGGLRASSRLPDTGEGPSRATGRQGSSAEQPLGGRLRKLSLGQYDNDAGGQLPFSKCAWGKAGVDYAPNLPPFPSPADVKETMTPGYPQDLDIIDGRILSSKESMCSTPAFPVSPETPYVKTALRHPPFSPPEPPLSSPASQHKGGREPRSCPETLTHAVGMSESPIGPKSTMLRADASSTPSFQQAFASSCTISSNGPGQRRESSSSAERQWVESSPKPMVSLLGSGRPTGSPLSAEFSGTRKDSPVLSCFPPSELQAPFHSHELSLAEPPDSLAPPSSQAFLGFGTAPVGSGLPPEEDLGALLANSHGASPTPSIPLTATGAADNGFLSHNFLTVAPGHSSHHSPGLQGQGVTLPGQPPLPEKKRASEGDRSLGSVSPSSSGFSSPHSGSTISIPFPNVLPDFSKASEAASPLPDSPGDKLVIVKFVQDTSKFWYKADISREQAIAMLKDKEPGSFIVRDSHSFRGAYGLAMKVATPPPSVLQLNKKAGDLANELVRHFLIECTPKGVRLKGCSNEPYFGSLTALVCQHSITPLALPCKLLIPERDPLEEIAESSPQTAANSAAELLKQGAACNVWYLNSVEMESLTGHQAIQKALSITLVQEPPPVSTVVHFKVSAQGITLTDNQRKLFFRRHYPVNSVIFCALDPQDRKWIKDGPSSKVFGFVARKQGSATDNVCHLFAEHDPEQPASAIVNFVSKVMIGSPKKV
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTEKLIDFGLEQEEEDTEFVPGDSTDTESSFSDADSSEEEFVEEKEASQVQSTKSKIATSESEDVTLKNIAKKNKRERNDKLIPQQSNESEAIEKPVQSTTEVELKTNELAESNSSVAVEGDENSYAETPKKKHSLIRKRRKSPLDSSSAQKVLKKNKLNTLEQAQQNWSKYIKEQDIQDELRIANKDGYVERQEFLAKTRAAHEEKIREMKKLP
The following text describes a protein:
Function:
Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
Subcellular Localization:
Secreted.
Sequence:
MKLSCAFVAVAALVATAVEANPETERRRSCALPTTYRWTSSAPLAQPKDGWVSLKDFTHVPYNGQHLVYASYHDSTKYGSMAFSPFKHWADMATATQTGMTQAAVAPTVFYFTPKKLWFLVSQWGSAPFTYRTSTDPTKVNGWSAPQPLFTGKVADSGTGPIDQTVIADDRKVYLFFVADNGKVYRTSMAIGDFPANFGTASEVILSDTQAKLFEAVQVYTVAGQNQYLMIVEAQGTNGRYFRSFTANSLDGEWKVQAGSESAPFAGKANSGASWTNDVSHGDLIRSNPDQTMTIDPCRLQLLYQGRDKNKVPSSYDLAPYRPGLLTLYGL
The following text describes a protein:
Function:
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
Subcellular Localization:
Cell outer membrane.
Sequence:
MSRKFTDKIKGIVMNNLVKNSGLAVIALATLNLSGCKHHPAGANAATGLSDGTGAQAYALAEGKGYQGQLKKDSEGRIINPLVAPANQTYYFDFDSTQLRSLDLGAIRVQANYLATHSTAKVRLEGNTDNRGSREYNIGLGWRRDQAVARILEQEGVAPKQIDMVSYGKERPAVMGNNENAWRLNRRVNLIYEAY
The following text describes a protein:
Function:
Immune regulatory cytokine.
Subcellular Localization:
Secreted.
Sequence:
MCLSVSQQGCMVTKMLLGCLVSLLFILNRVVDSRTLHTDSCSFNVYTHELRKYYADMLVHLFQEDQTCCFLRLLLRFYVERVFNNFSPSEPHQLRCSSAVANAFVSIRRDMQKCHCHCAEETHRQIDSMHTAFDKLQIQLAAQKAVGELDTVLDWLEALGHKA
The following text describes a protein:
Function:
Enzyme involved in the ethylene biosynthesis. May promote stem elongation by maximizing the extensibility cells, possibly by activating ethylene biosynthesis, in response to very-long-chain fatty acids (VLCFAs C20:0 to C30:0).
Sequence:
MESFPIINLEKLNGEERAITMEKIKDACENWGFFECVNHGISLELLDKVEKMTKEHYKKCMEERFKESIKNRGLDSLRSEVNDVDWESTFYLKHLPVSNISDVPDLDDDYRTLMKDFAGKIEKLSEELLDLLCENLGLEKGYLKKVFYGSKRPTFGTKVSNYPPCPNPDLVKGLRAHTDAGGIILLFQDDKVSGLQLLKDGEWVDVPPVKHSIVVNLGDQLEVITNGKYKSVEHRVLSQTDGEGRMSIASFYNPGSDSVIFPAPELIGKEAEKEKKENYPRFVFEDYMKLYSAVKFQAKEPRFEAMKAMETTVANNVGPLATA
The following text describes a protein:
Function:
Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity).
Subcellular Localization:
Lysosome. Golgi apparatus, trans-Golgi network. Membrane; Multi-pass membrane protein. Note=Colocalized with TGOLN2 in the trans-Golgi network. Colocalized with LAMP1 in the lysosome (By similarity).
Sequence:
MTEPETLALLDMKDTEISEKSPPQASVLQPEEEGGTESPGAESLRVGSSVGSPTVREGPEDGPDSTISEAATLPWGTDPHPSAPLPDPPGWRDIGPELLESEAPIKSEEPLKEDANLLPEKTVRAFVPIDLQCIERKPQEERIKHREAGPGELRNFLPARLSHPEPPERKWAEAVVRPPGRSCGGCGSCGGREALRAVASVVAALIFFPCLLYGAYAFLPFDAPRLPTMSSRLVYTLRCGVFATFPIVLGLLVYGLSLLCFSALRPFGEPRREVEIHRQYVAQSVQLFILYFFNLAVLSTYLPQDTLKLLPLLTGLFAISRLIYWLTFAVGRSFRGFGYGLTFLPLLAMLVWNLYYMFVVEPERMLSASESRLDYPDHVRSVSDYRPRSWG
The following text describes a protein:
Function:
Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration. Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF. Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration.
Subcellular Localization:
Cell junction, focal adhesion. Cytoplasm, cytoskeleton.
Sequence:
MSQVMSSPLLAGGPAVGLAPCEEPRRVLHPAPSPSLPPPCPYYTTEGWGAQALMAPMPCKGPPGRLQPAPQAGANASCLLKAPGEQVSGAQEDLDSYIDFSLESLNQMILELDPTFQLLPPGPGGPEAQPTQSTTLGKKKEEPEALDIKYIEVTSTRSRCHDGPRSCCSPSVTPPFGSPRTGGLLLSRDLPRETRSSSESLIFSGSQGRGHQHPAPPSAVPSSHPPTSPSISIPGMGSKASGPHGLGSPLVASPSLEKGLGGQGPQLSSRVSMLSGSPASDISYVFGSSQSLLHSSISSHQSSSRSLESPSSSSSSLNNLGPVSLYTRASDLQVPSNATPSMGQPRATRSPPLAKEHASSCPPSITNSMTDIPIVLINGFPEPGSPPSQRTPGPQDFVRPGATSSSMPCPATRSHSQTLPEAPPTASPEGPARDMQPTMKFVMDTSKYWFKPSISREQAIELLRKEEPGAFIVRDSSSYRGSFGLALKVQEAPTPAQSRPGEDSSDLIRHFLIESSAKGVHLKGADEEPYFGSLSAFVCQHSIMALALPCKLVIPQKELGGGDGASDPSADGQASCLKKSAGCHALYLSSVSVETLSGALAVEKAISATLERDVLPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLATLRFCGMDPEQRKWQKYCKPSRIFGFVAKSQTESQENVCHLFAEYDTLQPASQVIRLVGALLQDPERM
The following text describes a protein:
Function:
Involved in the assembly of the cytochrome c oxidase complex.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MTRDQTTSSTTTTTTPTNPDAAARSWLSGGSGGSPPPPPAPFAPSQDLQQQPPQSNNTTPQVVPGQQQQQQPSQQQQKQQKPTTHSSNRISLTEVASTISPSDFLSVHETPCARQGFMTGIGAGAGIGVLRWIMGLPIPKAANWGVGCGIVGAMAQYEYCQWQRRKEKEKMQRVVAVYTKKQAENRAKEAKEAKEKKAAEKGEVVQGTSMTAPGGEKKKSWYKFW
The following text describes a protein:
Function:
Lignin degradation and detoxification of lignin-derived products.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MGSAFLRILVTALCALWIFSELVVAKHAGITRHYKFDIKLQNVTRLCRTKSIVTVNGQIPGPRIIAREGDRLLIKVVNHVQYNVTLHWHGIRQLRSGWADGPAYVTQCPIQTGQSYVYNFTVTGQRGTLFWHAHISWLRATLYGPIVILPKKGVSYPFPLPHKEVPIIFGEWWKADTEKIISQALKTGGAPNISDAYTINGHPGLLYNCSAKDTFKLKVKPGKTYLLRLINAALNDELFFSIANHSLTVVEADAVYVKPFKTHIVLITPGQTTNVLLMAKAKAPNSTFLMAARPYATGPGSFDNTTTAGILEYDQNPSATNSKSKNKKLPLLKPSLPVFNDTTFATKFVKKIRSLANARFPAKVPKKVDRRFFFTIGLGSLPCSQNKTCQGPNNTMFAASVNNVSFVQPNIALLQSHFLNRSKGVYTTDFPTNPPFKFNYTGTPPSNTMTAKGTKVVVLPFNTSVELVMQDTSIIGAESHPLHLHGFNFFVVGQGFGNFDPKKDPVKFNLVDPAERNTVGVPSGGWVAIRFLADNPGVWFMHCHLEVHTSWGLKMAWVVNDGKRPSQKLPPPPSDLPKC
The following text describes a protein:
Function:
RNA-binding protein that plays a central role in spermatogenesis. Required for meiotic entry and germline differentiation, at the transition between G2 and M phases of meiosis I. Acts by regulating translation of specific mRNAs, possibly by binding to their 3'-UTR. Essential for translation of twine (twe) mRNA. Required for the expression of various genes such as CG6784, CG17210, CG15841 scpr-B, scpr-C, and rho-6.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Nuclear in primary spermatocytes until near the end of the meiotic prophase and cytoplasmic localization from then onward.
Sequence:
MHKIAAAPPPSATPGGGLETPLAAPKYGTLIPNRIFVGGISGDTTEADLTRVFSAYGTVKSTKIIVDRAGVSKGYGFVTFETEQEAQRLQADGECVVLRDRKLNIAPAIKKQPNPLQSIVATNGAVYYTTTPPAPISNIPMDQFAAAVYPPAAGVPAIYPPSAMQYQPFYQYYSVPMNVPTIWPQNYQENHSPLLHSPTSNPHSPHSQSHPQSPCWSIEDLRDTLPRV