lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTGLDRLSYQSRWAHVAPQRKFLLWLAMMILAFVLPPVGQGIELLIIAGLSCWLLRISLWRWCRWMAIPFGFLLVGVITIIFSISREPQMLLAGISVGPYWIGITRAGVVTANETFWRSLTALSATLWLVMNLPFPQLISLLKRAHIPRLLTEQILLTWRFLFILLDEAVAIRRAQTLRFGYCSLPNGYRSLAMLAGLLFTRVLMRYQQMTTTLDIKLYQGDFHL
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MVKRKFEDEDQTLREGQSGFATMNNNSYWKQEGESENGTLEDDGVDVTKVAQAAQAAGAVEADADADESTDSANMAAVVAAATAATAAAQAGGAEPEEPQQVVQTGEAEVDASLLPLRVNNRGRPLQTTKRAAQNRAAQRAFRQRKEQYIKELESEVKESKESLDELEKNYHQLREYAIKLSYRLSKDGDLPEPPACIANDVAQSS
The following text describes a protein:
Function:
Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs. Confers resistance to a diverse group of cationic or zwitterionic lipophilic compounds such as ethidium bromide, tetraphenylphosphonium, rhodamine, daunomycin, benzalkonium, rifampicin, tetracycline, puromycin, and to chemically unrelated, clinically important antibiotics such as chloramphenicol, erythromycin, and certain aminoglycosides and fluoroquinolones. Overexpression results in isopropyl-beta-D-thiogalactopyranoside (IPTG) exclusion and spectinomycin sensitivity. Transport of neutral substrates is electrogenic, whereas transport of cationic substrates is electroneutral. In addition to its role in multidrug resistance, confers extreme alkaline pH resistance, allowing the growth under conditions that are close to those used normally by alkaliphiles. This activity requires Na(+) or K(+).
Miscellaneous:
MISCELLANEOUS: A negative charge at position 26 is required for efficient transport of positively charged substrates, but not for neutral compounds. This negative charge does not play an essential role in the multidrug transport mechanism; MISCELLANEOUS: Has a sensitive conformational switch that can be triggered either by substrate binding or by attaching unrelated agents inside the pocket. Dissimilar substrates induce similar conformational changes.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MQNKLASGARLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASDMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGLFNLFNLVNGILWLSLMVIFLKDKQMGNSHEG
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MPSTQIRNSKTRTSLNGKYSKQVQNKSNGPVVDSLQLENLLLRDEDIFQTTLNSEDYLESLAPIMKDAIKSNGLSELLVKLNEIVKSKDEELNQASMESMDEINTCINTIDNIHKEANELNKQFIQVSSSLNKSAYELMSKKKNYVKYKDVCERINETQVVLNECIQVLELMNKILELIRQTKYFSALKLIDEIINIHIQKVEDFSFAKKIVDSIPHLTKMVKDESFENLCKWLSINLERKLQDIASGLYNNLDELQNNWSKIKKENGPTFLPYKINSPVELALRDPELNYNVFEDVSLQINLNAVYDAVLVYQTLQELDTLSSAYHKEWMSKYSRVIYPITTASVSKKDVVFDNNELYEYLRKIAAFFVTDKQLNLITKFQLRSNTQADELWLSYMTKLKPVLIQLLKHHNFTNIQELGSFKTIVGEFLQIMDNHDYDISELYEVMMMIFKEYYAPLTIQTFRKQFVASIQSDRYRPLTVTDEADYTAIMQNVWYKDDASFAPAYVKSFPVTFPFSEDYVHYCIQVRRLLKDVLRFIGDYYNYEIGELTNTIVNNIIEVVLSDEKGYGIAYEIEEFITRNENNKEITAQTYTNLEYYLFSLYEIGKLVNRELRKHTGMGVHNIDANDTFTLRAVETFNKLKKHAEETVFKMVDNKINELLDMVEYDEYLPVEKNDEANFAIKDFALFLENLFTSIFNNLPSQLRTLGLFRTYDFVSEYFLNVLKDANVYNRIFVANFDLDIQYLETSLRNLHGFKEDGDEANGNGGNVALESTFTELRQCIDLLNLEDYEEFINDSSFRMRRFDRVKYEDGINLIKKMQDNESKQQTSVSAMSERGTIGGVIPNSSSTRSFVNMLSNLSTDDAGNTSSGSIESTSTTSKLAQFTTRFKQNK
The following text describes a protein:
Function:
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MRKIKSLALLAVAALVIGCSSGSKDVEQASVNELYTKGTTSLQEGSYSEAIRYLKATTERFPGSVYQEQAMLDLIYANYKTQDYTQVLLMVDSFLHQFTQSPNQAYAVYMAGLTNAATGDNFIQDFFGIDRATRETTSMRTAFSNFQNLVRVFPNSPYSQDALARMAYIKDALARHELEIAKFYAKRKAWVAVANRVVGMLKQYPDTKATYEGLFLMQEAYEKMGLTALANDTQKIIDANKDKTFAPIEKPNEPDLKVPAVK
The following text describes a protein:
Function:
Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway.
Subcellular Localization:
Cell membrane. Note=The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells. Membrane localization of the Sca1 complex is regulated by scaA phosphorylation by PKB and PKB-related PKBR1.
Sequence:
MLLLNYTQNFQLITFLLFPFINTFDYNCLKPTTTTTTSPTSSKLGFLNRSKSNSNININELKNKFLEQQQEGSISNIAGVATTQQNPSIVINSSSSSSSSSSHHPHHQKTPSNSSSNFNLIKASFNQIGVAFNNNISPRSNRKEKEKDKDKDHQDNSNINNINNINNNINNNINNNNNNNNNNNNNNNMHNPTSSSPSINNNLKGKNVASIIAANGANLNNSLSNLHQHVNNNSNNNLTNSFNSVSHNNISISSGGSALSYNYTQQLNQNGGSNNGSTSNSTSNSANNSLLSLASSINGNIGSDENGSNVMYGGDIASSYHSMSIDPLKSSTNTETIEIMVVGDELSNKARFISSFLNNGIGEDPTLEISTKKSIAIQSGAYNVNINTTVGQEEFWGINDVYYRSSQGFIFVYNVNSRESFLSFLKFRDKIIHEKGTENILMAMVGLTSPLINQESGEESCIREVTQQEAKRMADLYSCSFVELNSFGLDCEHQIQSIVTDLLGRITSGLSSTNNNNSGNNSNNNNGNSNGNSSNNNSNNNSTNNLNNSAILNESIAQSIEVLMLGDIFVGKTQIIQRLLGNPFQNAYKETTEWNRNVYQMTVNDVRYLLKIVDTCGLDIEETLNRERLVSTQGFIFVYSIASRESFLMIEQLRKKLSSIKSETKIPSVLIANKGDSLIRQVTFDEGSKMAQHLGSHYFEVSSMFSDDESIGRPFEQLLIDIQKSGNASGFEPSEIKKKGYLFKEGKKLKSMSKYFFKASRGNLSYCKNESNKSKVKSIQLSEQIQLAIPHNVHEKKDVWPFSIILDPVSKHSINLIASTEEERNAWIKAIKFNCFLEDITSNIIDDVVKSMVSEIASGVAGSGSNNGNNNGHLKRSDTTQQLNNSGSFINGINANKPVPNFSNLSISGGGSSNNSNNSTPMSSPYGSSNNFSSHLSQSTSSMSMSPQQQLQSVLLSSSNLSSSMNSSFSYSSSISSSYTDSMSGSPPDSNGQVFPQSPQLKKTLFQRTTSFSKGSKLK
The following text describes a protein:
Function:
May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MKKFFQEIKADIKFKSAGPGQKLTDTAGEKGSKERQSQQASKQPRQGPTNEAQMAAAAALARLEQKQPRSRGPTSQDSIRNQVKKELQAEATVSGISESSGANVIPEAKEEGSANLSVTGVYFTCPFTGAILRKDQRDAHIKEVINEYADKDPVTASIMKIHTFNRDREKVKLGVDTIAKYLDNIHLHPEEEKYRKIKLQNKVFQERINCLEGANEFFRAIGFEKTSLPVPEQEALEEFYVLGEDAQVEKLEQHKVALQNSEPVRAQLARQRRIFKPSPLAAQFDLPGDFFNLTTEELKREQKLRTDAVERLSVLRTKAMREKEEQREMRKYTYTLLRVRFPDGHILQGTFYARERLSALYSYVREALQSDWLPFELIPVGGHKLLDDSLAFNECGLVPSALLTFTWDAAVMDDIKASGAEQPPGALKPELLATVESLS
The following text describes a protein:
Function:
Acts as a guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
Subcellular Localization:
Cytoplasm.
Sequence:
MREEKMEPEETEVDLSSSWSPITRERLLTCANLSDFAGKKRKQDPSSDAENSARILEDCEEDDFPISDHMQDSEGPCNKRVKPVDKGASVTGIITPVKTPALKRLGQSIQRSISFRTEARPLPPMPRSRQKASSFPRRRSSQLWSDTVDNMSHELSTKEIKRQEVIYELTQGEKQLIEDLSLVKKVYYEPMLKLDIMTESELGQIFGTLDSLIPLHEDLLVRLEGLRGAEKTVQEVGPTMMDWFPCLEAYITYCCNQVGAKALLDQKKQDKRVEQFLRLCQESSFSRKLDLWNFLDLPRSRLVKYPLLLKEIQKSTPLDHPDEDALPQAMELIQRIITEVNLKTGEAECQFYRRGLCYAEDSQRVAEIQASRFLYCHGELKSTKGQKLHVFLFELVLVLTRPVAQDREGPVQFQVYRQPMPAAHLHLEDLPDGEPSSSGSFRGAFTGNDKVKNCFRVSTTGRSKSQSHSLQANDSFNKQQWISCLRQAMVQSRDRQAQSSPCNPNERLSPEPALYNNIAELTINSDVDMPDT
The following text describes a protein:
Function:
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MFFTGTLQEGITLAVQESKAVVCFVPDNGETSSTWQEEYFQGDEEFTRLLGSQSVLLRIAKDSQEAGFLASVCPISKYPTVVIIRNGMLREYIVPDISKEGFRNRVMAAIADSKPQSQTISSSVPQQSAQQAQELSSPAARAPQTVTTAPTPAVDTTRASITQGQSSQNVSTRSSGGRANDITYSSGSRMYSATVPRKQEREYDTPQSSNKAKETTEQKNDDMKGKAPIRTNKDEKSKNQKSAAASPAPHSTSVPVPPSQYRLQVRLFDGSSVRSTFSPLHTIRSDVRPWLDNQLEEKRPYNLKLIMTPLPNKTLTIAEEDQTLSELISGSTATFVMVPIKAYTEAYSDSGSLPVRAVSSAYGLVTSVVGGAVGYIGSFIGYSPNRASSSESAPPQSREFQASADATRRPRQWGANIRTLGDQRDGQNSQFYNGNQLNFEPRQGDDR
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MFLGLLLKISTSAPIITNSTYLVFEKEGKRVGKVIFGLYYNECPKTVENYLAAFSCQPKREFCYNNTYVAKLNPNKRLSIGVTLATKSVKGDHESNHEENKLLHDRAYLITSNTHYKTFLTGEFYITFRAWPKYNEENIVFGRVLRGFDVLEKLKINSNEKDVDKIKIIDSGIIQDDDDDDYDL
The following text describes a protein:
Function:
Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTVTDAQLSTMSEAGPGDAVGRRVSCDGERGTVRYVGKVPPTAGIWLGVEWDNPERGKHDGTHEGVQYFKCSHPTGGSFVRPRKASFGVDFLTALRQRYDMEMEQDSAEELKIANKPVELVGFETVCQKLSQLNSLEAVSLQGSEVAGAGPDNEIQQNTPNILSLDLSESLLASWDDVASITRQLIKLRELQLSYNRLHMPANPACLSHCFASLKVLVLNSTGITWSEVLVCAPMWPVLEKLCLSSNAITVLQKPVDVLQSLSLLDLSKNPLAGGDELQNIAHLPKLEKLILSNTGLSSIRFNDVGPGCKTSMFPSLKCLVVENNNISEWSFVNELEKLPNLQQLSCFNNPLMTAGKSPETVRQLIIAKVGGLQLLNKSKIQPVERRGAELDYRKMFGRVWLECGGDRDPERDRPSQAFAAEHPRFRTLIQKYGAPEEGELKQQQPFALKNQLLTITFVCPDVTEKKPIEKKLPDSMNIQKVKGLLFRLLKVPGAELRLSYTSSKMEGKEIEIDNDLKPLQFYSIEDGDRVLVRWS
The following text describes a protein:
Function:
Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MRPEFWLLSMGSLFPVLLLWLLSCPRLQLGHAQDPAMVHLPGGRFLMGTNAPDGRDGEGPAREVTVKPFAIDVFPITNKDFREFVREKKYQTEAEAFGWSFVFEDFVSPELRKQANEMPAVLWWLPVQKAFWRQPAGPGSGIREKLELPVVHVSWNDAGAYCAWRGKRLPTEEEWEFAARGGLKGQVYPWGNQFQLNRTNLWQGKFPKGDRAEDGFHGLSPVNAFPPQNNYGLYDLMGNVWEWTASTYQAAGQDMRVLRGASWIDTADGSANHRARVTTRMGNTPDSASDNLGFRCASSEGRLKEDL
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRIFLEWGLGVTMTLLSSLHACLPPGPNMSHWPESNWTAPQEFVILGFSRWPQGLRGLLFAFLLPLYLATLAGNLLILGLAVTDPALHTPMYFFLGALSAVEVAYTLVLTPRMLAGFLLPPGGHAVAPSTCAAQMGLFVALGGSECLLLAAMALDRYLAICRPLYYPQLMTTGLCWCLLASCCVGGSVLALGLTTAIFRLPFCRGGSVNHVFCDLPAVLVLACGNRDLQERVLLAACLVLLVLPLALILLSYSRVLAVILGVGGAAGRRKAFNTVASHLTVAVLHYSCATAMYARPLSSRSLEEDKLVSLIYINLTPLLYPAIYTLRNRDVQGALQRAVSHRTPGTVRQADVT
The following text describes a protein:
Function:
May play a role in regulating the integrity of microtubules possibly by influencing their stability. Involved in an anchoring mechanism to maintain tea2 and tip1 at growing microtubule ends. Strongly stimulates the ATPase activity of tea2.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Associated with microtubules. During metaphase, localizes to astral microtubules, spindle microtubules, and intranuclear microtubules (INMs).
Sequence:
MSESRQELLAWINQVTSLGLTRIEDCGKGYAMIQIFDSIYQDIPLKKVNFECNNEYQYINNWKVLQQVFLKKGIDKVVDPERLSRCKMQDNLEFVQWAKRFWDQYYPGGDYDALARRGNRGPANTRVMNSSAGATGPSRRRQVSSGSSTPSMTKSSANNNNVSSTANTAAVLRAKQAQQQITSLETQLYEVNETMFGLERERDFYFNKLREIEILVQTHLTTSPMSMENMLERIQAILYSTEDGFELPPDQPADLTTALTDHDTNNVAEEAQMTDLKDSETQRVPSAPDFVHARLQSLEVDDDENITF
The following text describes a protein:
Function:
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MNGRACRILQEGAAELGVEISDELVTLFSLFADELKKWNRKINLTAITGDEEIALKHFVDSLALCRLVSGDDELLDLGSGGGFPVLPLALVFPTMTAVSVDAVEKKIIFQRHAARLLGCRRFEAIHARGEDLPRMLERRFNRIVSRAFSDIPSFARMALPLLMPQGTIIAMKGRGGAEEADAARGALEEMGLTVVRVTEYRLPFSGDARTLVEIGFC
The following text describes a protein:
Function:
Transcription regulator that plays a critical role in the expression of beta-lactamase AmpC, acting by positive regulation of the ampC gene. Has a wider role in the regulation of expression of genes involved in proteolysis, quorum sensing, and virulence. Acts by binding directly to the promoter region of the ampC gene. Probably does not regulate transcription of its own gene.
Miscellaneous:
MISCELLANEOUS: Orthologs in several species of Enterobacteria, but no known ortholog in E.coli.
Subcellular Localization:
Cytoplasm. Membrane.
Domain:
Effector binding domain recognizes specific cell-wall-derived muropeptide products, probably acting as a link between cell-wall recycling/repair and the induction of resistance to beta-lactam antibiotics.
Sequence:
MVRPHLPLNALRAFEASARHLSFTRAAIELCVTQAAVSHQVKSLEERLGVALFKRLPRGLMLTHEGESLLPVLCDSFDRIAGLLERFEGGHYRDVLTVGAVGTFTVGWLLPRLEDFQARHPFIDLRLSTHNNRVDIAAEGLDYAIRFGGGAWHGTEALALFEAPLTVLCCPEVAAQLHSPADLLQHTLLRSYRADEWPLWFQAAGLPAHAPLTRSIVFDTSLAMLEAARQGVGVALAPAAMFARQLASESIRRPFATEVSTGSYWLTRLQSRGETSAMLAFRGWLLEMAAVEARGR
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Sequence:
MATYKPLEYLEHLKKIVPDLSDQINNIKDTYENKLWHQLTKQIEMIIISPQLLEKKELFNFYTNFIRDFENKLRPLSLVEICIAVARQFDTDESRKFIETISQKVKKDKSAYILTLSYIANMNLRSGVAEQLQDCKKTLELAKEELQGVTGLDTIVYSSFYRVSTDYHMAKSQASEFYKNALMYLSYCKLETISQEEQASLAYNLCIAALVGENVYGFGDLIANPILKALEGSQHNWLIAFLKAFNIGDIQQFEGLMSQHRDIISTQTAITNNMQKLRQKISILSLLELAFRTPSDKRSISFSKIAQATKLPLGEIEHLLMKSLSLNLIKGSIDQTVEIIHITWVTPRILDLNQINSMNNRIAEWTEKAKTSLRLVEDDTVDLVA
The following text describes a protein:
Function:
Catalyzes the non-oxidative deamination of L-phenylalanine to form trans-cinnamic acid and a free ammonium ion (By similarity). Facilitates the commitment step in phenylpropanoid pathways that produce secondary metabolites such as lignins, coumarins and flavonoids (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
ETGRIHHGGNFQAMAVTNAMEKTRLALHHIGKIIFAQSTELINPATNRGLPPSLAASDPSLNYHVKGVDIATAAYAAELGYLASPVSTHIQSAEMHNQAVNSMALVSARATINSIDVLSMLVATYLYNLCQALDLRALQAEF
The following text describes a protein:
Function:
Acts as a negative regulator of cortical contractions during early embryonic cell division, possibly by regulating rho-1-dependent actomyosin contractility. Plays a role in polarity establishment in early embryos by regulating the size of the anterior and posterior cortex in the first asymmetric cell division. Might play a role in cell cycle progression. In the germline, involved in the regulation of meiotic progression during oogenesis, possibly by modulating the timing of mpk-1 activation. Plays a role in meiotic recombination events. Involved in pharyngeal pumping.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Localized to the anterior cortex in embryos; localization to the anterior cortex depends on par-3 and rho-1.
Sequence:
MAPAVLQKPGVIKDPSIAALFSNKDPEQRYQDLREIGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAVEKWNDILKEVSFLNTVVHPHIVDYKACFLKDTTCWLVMEYCIGSAADIVDVLRKGMREVEIAAICSQTLDALRYLHSLKRIHRDIKAGNILLSDHAIVKLADFGSASLVDPAQTFIGTPFFMAPEVILAMDEGHYTDRADIWSLGITCIELAERRPPLFSMNAMSALYHIAQNDPPTLSPIDTSEQPEWSLEFVQFIDKCLRKPAEERMSAEECFRHPFIQRSRPSDTIQELIQRTKNMVLELDNFQYKKMRKLMYLDETEGKEGSEGNGASDDLDFHGNEANSIGRAGDSASSRSASLTSFRSMQSSGGAGLLVSTNTTGAMDNVHGSSGYGNGSSSTTSSARRRPPIPSQMLSSTSTSGVGTMPSHGSVGASITAIAVNPTPSPSEPIPTSQPTSKSESSSILETAHDDPLDTSIRAPVKDLHMPHRAVKERIATLQNHKFATLRSQRIINQEQEEYTKENNMYEQMSKYKHLRQAHHKELQQFEERCALDREQLRVKMDRELEQLTTTYSKEKMRVRCSQNNELDKRKKDIEDGEKKMKKTKNSQNQQQMKLYSAQQLKEYKYNKEAQKTRLRSLNMPRSTYENAMKEVKADLNRVKDARENDFDEKLRAELEDEIVRYRRQQLSNLHQLEEQLDDEDVNVQERQMDTRHGLLSKQHEMTRDLEIQHLNELHAMKKRHLETQHEAESASQNEYTQRQQDELRKKHAMQSRQQPRDLKIQEAQIRKQYRQVVKTQTRQFKLYLTQMVQVVPKDEQKELTSRLKQDQMQKVALLASQYESQIKKMVQDKTVKLESWQEDEQRVLSEKLEKELEELIAYQKKTRATLEEQIKKERTALEERIGTRRAMLEQKIIEEREQMGEMRRLKKEQIRDRHSQERHRLENHFVRTGSTSRSSGGIAPGVGNSSSIQMAM
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNQSKISKIAKHLCKLWSLHGLPIFTLKNGKFVNKPTKSYIFSLLFVAVVVAIYTRIKKFDNRVYSYITTIQFFSIFLLNTGFIICSHRKRKKIEKIFANLLHAETMVHRFSGDKFPSSKIGRNLLIYIIFQFMLTLVQFVSVTSTLSRDNLSLYFEILCHQCLLTYSFNFNIMIFFFLFSLREIGKHFVGAIQAKMSHKVLDREFRQVMEISTLLHNVANDVHQTFQLVLLLKIFKDFILAVSSAYHSAFTMANLTTVLSYLRNITEVGVFLFATLMSNFGMVYYFDEISKQDVNLMEIMDEILISFKDDLIVSYKSVELFDLRLKNRNSTFYVCGLFPLNCTFIYTMIAGMASYMIYLVQFTQVQQKDSTVSNN
The following text describes a protein:
Function:
C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. FixP subunit is required for transferring electrons from donor cytochrome c via its heme groups to FixO subunit. From there, electrons are shuttled to the catalytic binuclear center of FixN subunit where oxygen reduction takes place. The complex also functions as a proton pump.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MTDHSEFDSVSGKTTTGHEWDGIKELNTPLPRWWVICFYLTIVWAIGYWIVYPAWPLISSNTTGLFGYSSRADVAVELANLEKIRGDKMAALGAASLADVEKDPALLALARAKGKTVFGDNCAPCHGSGGAGAKGFPNLNDDDWLWGGTLDQIMQTIQFGARSGHAKTHEGQMLAFGKDGVLKGDEIVTVANYVRSLSGLPTRKGYDAAKGEKIFVENCVACHGDGGKGNQEMGAPNLTDKIWLYGSDEAALIETISQGRAGVMPAWEGRLDPSTIKAMAVYVHSLGGGK
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDEELQIKEQLTQVPFHTLLGFEKQMKSQQQAKTQIKDQELPKKLKGGPEVRDARKPLPKIKNQPQKKQEQRDPRFDKTSGDLSLTKFYKSYDFIGKMKSNEMQVLKKQSEKLDNESKQKIKQIIGKQKDELIKQEQFLKKQQTFSKLKKKNYHPKQSIIKQELLKQKFDSLEATGKLDAYMKQKKKSISKKLDFASKKIKK
The following text describes a protein:
Function:
Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFTSRIYTLVFVMKPQQILLGMKKRGFGAGKWNGFGGKVEDGETIEEGAKRELLEESGLIVDTLQKIGKITFEFVGNTELMDVHIFYADSFHGTPKESDEMCPQWFQLKQIPFRDMWPDDSYWFPLMLQKKEFHGYFKFQGQDIILSYTLNEVEIV
The following text describes a protein:
Function:
Catalyzes the two-electron reduction of biliverdin IX-alpha to the tetrapyrrole chromophore phytochromobilin (PPhiB).
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MALSMEFGFSIGSCFKAPNPPVLISASPNKINFTLRRRKKRFLLRVSAVSYKEFAESALEETRKRIVLEPSHLQEKYSSMTGLDGKTELQMLAFKSSKIRLLRSMAIENETMQVFDFAGFMEPEYDTPIFCANFFTSTNVNIVVLDLNPLHQLTDQTDYQDKYYNKIMSIYHKYAETFPWGGKLTGESIKFFSPLVMWTRFSSSKEKHKALFSAFLEYYQAWLEMTIQVREEMEPSHVRANCEAQHKYLTWRAQKDPGHGLLKRLVGEAKAKELLRDFLFNGVDELGTKTFIDYFPEYQTEDGTVSDKRSIIGKSYETRPWDLTGQFIG
The following text describes a protein:
Function:
3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEEAACETPSIYSNVVKNKIMVYKRMTVAQWKEERAREVAKEKASRIPVSDTPVTKPDEPPKPIETGLSSEEELALLPRLYTPVHGLSQHGYVTNIPTDAEIEKAKIGIEASKGWEVCDRCKTRFQIVLPLIPKPNGKRNGVAVIKILETLPGCTTAEHHVFKVSEAKRLATVLNFEKTPENEANSSIPTQPICIDCEMGYTVHGLELIRLTATSWPSGSSLLDILVRPYGEILDLNSRYSGIYPQDITSAVPYSFPGSQLLAESKGKLRIVDSPAIARSLLFSFLTPSTPIIGHGLENDLNATRFIHPTIIDTALLFPHKAGLPFRNGLKMLMQSLLNRNIQMVTYTEGKVDGHDSEEDANAAGDLVRFRIGKEWERMQRAGWKLKNGVFEPPEIVSALGKGGKWIKEGGHDGRNGNDGNDGEEEENEQEIKDERIFVSVSASAGSKRSREDMEG
The following text describes a protein:
Function:
Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Multi-pass membrane protein.
Sequence:
MMRIPNRSIQAANIFFSSGAILLLIAGLIMENWVELIPKVRKDKVTHSPWLGCCPPFWPEESLEAIRRMMMMSLNISIYLNLIIGLQFTYMISQNKCVHLLIGFLSFFTGCLLFYAIIVYHHKLNKGQYVYFVNYKTKWIVFTIYLTIALFLTCGIFSFIQCTNRCACMKFCVPHTESSSKAMTQNTIQVISLPPRSEMPRSIVHMHSDMPGKEGSISKPHLQSRRVTWAL
The following text describes a protein:
Function:
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Modulates SLC51A glycosylation, membrane trafficking and stability activities. The Ost-alpha/Ost-beta complex efficiently transports the major species of bile acids (taurocholate). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols. Able to transport eicosanoids such as prostaglandin E2 (By similarity).
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes.
Domain:
The transmembrane domain (TM) is the major site of interaction with SLC51A. The extracellular-membrane interface is absolutely required for transport activity. The intracellular-membrane interface is necessary for establishing the correct membrane orientation that is essential for the heterodimer Ost-alpha/Ost-beta complex formation and transport activity at the cell membrane surface (By similarity).
Sequence:
MEHSEGAPGDPAGTVVPQELLEEMLWFFRVEDASPWNHSILALAAVVVIISMVLLGRSIQASRKEKMQPPEKETPEVLHLDEAKDHNSLNNLRETLLSEKPNLAQVELELKERDVLSVFLPDVPETES
The following text describes a protein:
Function:
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Splicing acceptor site not canonical.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.
Domain:
The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
Sequence:
MSRPGQGVMVPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDARGSVVLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLTVGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPIAPAAPPAPPPPPPPLPPGGPPGALVVRPSATFAGAALWAAPATGPTEPAPPPGVPPRSPSAPNGAPTPGQNNLSRPGPQRSTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRNKSVRPELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFADTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAMAKA