lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable).
Subcellular Localization:
Nucleus.
Sequence:
MEEGILLKKYVESSDKDIRYMALSDLAARLNDANHLKNLKLESFPDTLDVLLQALSDASPEVQQEAVRCVAIISSKIPQDKLKSTVENLLSGVAGKKSKNYLSALSLLLSNSNVQPFVNKFYTSTVFPSFLQILKQYNVAQEEFFAILCVVCDSLEIYHSNLSTLLPNNFELCIDVFQKCTTQCQRELIIKKACYLLSDVSLYGPRFAYKYIIEVLDRGLGPSTQMSEVNISIKLLNEILLSSKKEKDSSTSFISTAVADYTNKILSLLKKEEAPDELTQKLLEVLGLLLEYQQVNILKIWPELHGLLISKISYDPNLISDTNDEDDIADFLEEMSDYSSIYEDEEDVSWIVRRESLKVVLSVILSRLEYLPIVLQALGTSVVSKLNDREESVCLISIEVLKQAFLHVPRWIEVYATSNDRKRRYEGLPSDRSAISDTSIYLVSVIGKHVSKLSDKTPLSIVSELLNLVTVIFSSRDLGVQSEFSNLSSIIYRFPDFSTLDIKIKLNLVRLISAIISCGCEEIENMESKMSTILSLAVQNNYPQLSYEALITELSFCKYIHKKQPTNVSTDFSTMIDSSLQLLESKISDLKVRLALIDLVSQYVILFYEPDFDSIFLRRVLIILCKKLQEEPTRSAAARALCDIFMSVTDITKIENGTKIYEEILQDCCRHIDKSGNEFTTAYLELLEVLLKVGQKYLAESLLEHILGLLIETLKRNTENTVAILKCLLIIPLSILLKSKNLLIDTIISHLQSSTIHLNEESVCLLSRIIAVISKEEDLELIINSFTCAQKPVEEMVTLALIAAQLICIFQSKAIVTSLNKSFMSPKSEVRIKVFTTLIFGQLDYGKLTLPANEYFDTIASNLNSPNADVMKAAAIALGSLTSQSEKFIKELCALYVSDAYDKELLLISFLTFLKKSKIDYETADKIWDILSKDIENIKDFSTSPFRTLLSECLGLLICNESSSLYYKLELLSSSEASNHMLLSLSVFRFSLTLDCPKLKAYEKQFFEKAYKLFQNPDLEVSQETLQVIISVIKNRRSCIADVYNELLQGLISKSSVDSSNVHVVQMGPFQHVVDNSINQRQLVFETLYSLLDIPESLNHLTHFLQVSVMGLEDEHYIKLVSLSILEKLVDCSPSIIDEQVDTILEALRKIIELRKTEKTLKTDSDNILDLVRSALRVLFTMKLKCDNPVISEFESQVQKGPYSLEYEGIKNEIKTTIKT
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MAPVDSGSDSDGSASDGDDGSVNEEESRSDEEYDSAAEHDDDDDNNEAEGEDDNSVEVSDQYSSDEFEDQGSSDDDEDRLARQAELDSDEDDDSDDEDGAAASLLHTDNLSSDDEDPTGTDNRIGRVPLHWYDDYSHIGYDAHGNQVIKSSSAFNNQDLLDQAIQVADEMEGDGKFKVYDALNARDVTLTPRQIELIRRLQSGAFAHPEHDANPDYIDYFSGVDPEISGINSNRYEKKSRFQPSKWEKLQVRRLLHRLKCGSINMDDKPFELWKGDEEDELALRKGPQHMPAPKLPPPGHAFSYNPPEEYLPTKEELAEWSEMDPEDRPYGHYIPQKFHNLRSVGAYQHAVKERFERCLDLYLCPRAMKRRLNIDPESLVPQLPRASDLRPFPTTKCIRYEVPGGDESGGDGVVRCLSVSPEGQYLASGGEDGVVRLWEVQTGRLLRSWDLVDKPIASLEWNPNRSHHTLLAAIGQCSVIISTGTAGPDDAEVTDALLSAAASCKNGGNVAPDSRASKAVKWISLKKKYNTSKATPISAYGGTSGPIALIRTNKDISSLRWHRKGDYFVTVSPKAGAASVLIHQLSKAASQQPFGKMKGEAQLACFHPQKPFLFVASKEHVRVYHLVKQVMVKRLMSGCRHISSLDVHVSGDHLVVGSLDRRLVWFDLDLASTPYKTLKYHERALRSVGFHPRYPLMASASDDGSIHVFHSMVYSDLMRNPLIVPVKVLRGHSVVNSLGALAMVFHPTQPWLFSAGADGKIHLFQDL
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MAEYNEDTFSFETLRNNVSNFCLFFNKYTQDQRQKLLDDKNEHLKQCSELWEKQKKTEKELERAQLREKEVMDNIEKEKLEQLTITQEIQRYTEILEDMNRRKALLAEEIERQQSVLTAKRELKAKEEHHFMKQKSLDNPELQFWEKYLGMRIEGVREDELRIVFVNIDDKNWKKRFSFHINFMEKLYEVTKCNPPLSNLEELVERLNKTRNFFRFLKEIRMSFYIYAHSNS
The following text describes a protein:
Function:
NADH-dependent flavin reductase that acts in the coenzyme Q biosynthetic pathway. Required for synthesis of the p-hydroxybenzoic acid (PHB) precursor to form a quinone backbone.
Subcellular Localization:
Mitochondrion.
Sequence:
MSIRFTHCFTSSSSLPCYILRHLPFSNFNRYSTASHDNVNAFRLLMRRFAQPVVIITSGFADGHRAGMTASSFTPVSLTPNPVISFNIKIPSRTANAIQQSNRVIVHLLSSSIKKHSEWASLLAKQKHQINPLMNSEKNSTSVEDLPGSNRTQQTSSHSLLHPLHPIDVSLSKEGLPCLVDSLGLLHCSIIHSYQVQDHILFVANVERVEHGSSPLESSSGLVYYNRNYCSTSPLSPIIDSFES
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 2 and elongation factor 3A.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MILEDTDLPLSHEQPSYSQIKDVLDKIPTGEHLWDLPKYEEKIILNWLIKLLATNLEWITVEEERDYLVSTICERIAERSGRLAAPTRKREFSLSNGVSVVLREPTMTYNTLGFKTWGSAPLLSANLPKWEDLSNSINALELGAGTGLVGISAAIQLGWQVVCTDLPDIVENMQYNVDYNSELIQQYAGSVSCHVLDWMNPPDDDNRPSWLIKPFQRIIASDCIYETHFGELAIALFRKYLAKDGIVITEYPLRETHLEEIGVFEKGMDAAGFERQMGEEIGEEDFGSLYPVTCRWSRWKYHG
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites.
Subcellular Localization:
Nucleus.
Sequence:
MADGGSGMCWCLRRCGKNQEVLLLPDGEEVTMGRGLGVTYQLKPTLCPLMISRTHCLFKQNARDEWTVTDNKSLNGVWRNKERLEPHKAYTLSEGTLIQLGVPPPNMESAEFEYILVREHLDKVSGSLIRPLPGKTKATRTKRKFPSEDADASGNEGPSNFSIPKFCRVSRDGEDSAKSLRTSHKQPKASGVEPELNDSVETDTVSPTQQQCCRSTLQLSRVRETMEEIRRLNVQIQEKQIEMQEKLNHPQESQLGSNSYLVVQKELQALRNQLSNEQEQHLQSVKELKEIFQEEQQSMGSQKQAEEEHLKEQLAQALQEHTQLMQELNRNKNDFEQIIQAKNKELQETKEEKEKVCAQKEEVLNHMNDVLDNELQCIICSEHFIEAVTLNCAHSFCSYCIKSWRKRKEECPICRQEILSETRSLVLDNCIDSMVDKLSPEMKNRRAALILERKAEMVQAEESNPVLVVSDSSSFLSDTFYISSSSSDSDELGSDFWMVNEEEEYEESLFGCGTDELDSSDFESDDDDSFLIV
The following text describes a protein:
Function:
Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan.
Sequence:
MYTNSDFVVIKALEDGVNVIGLTRGADTRFHHSEKLDKGEVLIAQFTEHTSAIKVRGKAYIQTRHGVIESEGKK
The following text describes a protein:
Function:
Receptor for the peptide pheromone a factor.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSYKSAIIGLCLLAVILLAPPLAWHSHTKNIPAIILITWLLTMNLTCIVDAAIWSDDDFLTRWDGKGWCDIVIKLQVGANIGISCAVTNIIYNLHTILKADSVLPDLSSWTKIVKDLVISLFTPVMVMGFSYLLQVFRYGIARYNGCQNLLSPTWITTVLYTMWMLIWSFVGAVYATLVLFVFYKKRKDVRDILHCTNSGLNLTRFARLLIFCFIIILVMFPFSVYTFVQDLQQVEGHYTFKNTHSSTIWNTIIKFDPGRPIYNIWLYVLMSYLVFLIFGLGSDALHMYSKFLRSIKLGFVLDMWKRFIDKNKEKRVGILLNKLSSRKESRNPFSTDSENYISTCTENYSPCVGTPISQAHFYVDYRIPDDPRKSQNKSKKYLFADKETDDILDEIDLKESRHIPYVTQGQSFDDEISLGGFSKVTLDYSEKLHNSASSNFEGESLCYSPASKEENSSSNEHSSENTAGP
The following text describes a protein:
Function:
Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Sequence:
MSLLRDVSLQDPRERFELLQRVGAGTYGDVYKARDTDTSELAAVKIVKLDPGDDISALQQEITILRECRHPNVVAYIGSYLRGDRLWICMEFCGGGSLQEVYQATGPLEEKQIAYVCREALKGLQHLHSQGKIHRDIKGANLLLTLHGDVKLADFGVAGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSGFQPPKLRDKAHWSQDFHQFLKLALTKNPKKRPTAEKLLQHPFTIQALPRTLLTQLLDKVNDPHLGVPSSDDCDLETYDVFPDTIYSRGQHSQAERTPSEIQFHQVKFGTPRRKETEPLSEPWEEEWTLLGKEELTGSLLQSVQEALEERSLTMKPALELQSLISPEDGMATVKRSPFQGTGRSEPLSLPPSETSPVLSTEWATMRRKEDTERSSCHGLPPTPKVHMGACFSKVFNGCPLKIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLIAHRCSWLYCINNVLLSLSGKSSHVWAHDLLGLFEQRRQQRQVPLSIPTNRLTQRIIPRRFALSNKIADTKGCLMCRVVRNPYTENTFLLAALPSSLLLLQWYEPLQKFMLLKHFPTNLPTPLGLLELLVLEGEELPQVCVGATGPGRPGLELHFHIVPLEGGPTPSNPIPPEGTPGLAQQVIQMDRDTVLVSFERCVRIVNLQGNPTGALAPELTFDFPIETVVCLQDSVLAFWRHGMQGRSLEANEVTQEITDKTRVFQVLGAHKDIILQSLPTDNPGAHSNLYILTGHQSSY
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSHEPQKPAKSAVKEPPVVSEETRTTDKCLADFCLKGGSGLIIGSAVTLFFTRPQTYPIWLGLGVGMGVAYDCCQARWNQQ
The following text describes a protein:
Function:
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Domain:
Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
Sequence:
MGNRIPEEVVEQIRTSSDIVEVIGEYVQLRKQGRNYFGLCPFHGENSPSFSVSSDKQIFHCFGCGEGGNVFSFLMKMEGLAFTEAVQKLGERNGIAVAEYTSGQGQQEDISDDTVIMQQAHELLKKYYHHLLVNTEEGNEALSYLLNRGITKEMIEKFEIGYASPAWDAATKILQKRGLSLSTMEQAGLLIRSEKDGSHYDRFRGRVMFPIYTLQGKVIAFSGRALGDDTPKYLNSPETPIFHKSKLLYNFHQARPFIRKRGQVVLFEGYADVLAAVKSGVEEAVATMGTALTEEQAKLLRRNVETVVLCYDGDKAGREATMKAGQLLLKVGCQVKVTSLPDKLDPDEYVQQYGTTAFENLVKSSVSFVGFKINYLRLGKNLQDESGKEEYVKSVLKELSLLQDAMQAESYLKSLSQEFSYSMETLLNQLHQYRKEQKVQQKQIKQVAKPSQVVQTKPKLTGFERAEREIIYHMLQSAEVAVRMESHIEDFHTEEHKGILYELYAYYEKGNEPSVGTFLSWLSDEKLKNIITDISTDEFINPEYTEEVLQGHLETLRRHQEKLEKMEIIFKVKQMEKTDPVEAAKYYVAYLQNQKARK
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Sequence:
MASGDSVKKLCEELACPICLGYFKKPVMIISCGHNFCQSCLDQCWEGKEASCPQCREKVQEGDIRPNRQLANLVEVAKELGSQKAEEKGSVCQRHQEPFKLFCKDHEAPICVVCDRSKEHENHKVIPLDEASKEYKDQIWNLLETLKKERKKILAYKADAEKTQREKDRTVAAFRRMHQFLEEQEKILLAKMEEVEKEISAKGEEHLARLSKELSSLSKLIQEMEEKLQQPASELLQVRPRLSPWGAETGSLAVIQSLAVEFILINRFGSRKCLWLLQRMRLYTFIHSFIHSLFTLHLFPSPTAHVTLDPSTAHPQLICSEDLRRVTFGEKEQDLPDNPERFNEYFFVLGQEGFNGGRHFWEVLLGNEGEWSVGVARKSVQRKGCIPFGPHAGIWQVGKCWSEYWFFFNNGVSSSLNLSKESKRVRVTLNYEGGRVAFYDADSAALMYEYSPASFSGETLLPFFSMFSEGHLELSP
The following text describes a protein:
Function:
Mitochondrial glutamate/H(+) symporter. Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton. Plays a role in the control of glucose-stimulated insulin secretion.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYSSMSDCLIKTIRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHHLARDGKKLTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQKKLMAAQAQLNPSSGAAAAESVMESRTTAMQITRDLLRSKGIAGLYKGLGATLLRDVPFSIVYFPLFANLNKLGQKSPDVKAPFYVSFLAGCVAGSTAAVAVNPCDVIKTRLQSLQRGVNEDTYSGIVDCARKIWQKEGPAAFLKGAYCRALVIAPLFGIAQVVYFIGIAEYILDMLPRRRD
The following text describes a protein:
Function:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Sequence:
MLSQPSSFTDVIKSKFLAILFDQLEVRSVAMVTQTMLSLYSYNATTGVVLDVGEKIEVLPVVNGYVVEGGVMRLPLGGQRLCEVMNSYLINRKVRFASNAEFLLARYAVEKLCFVSMDYTDDHEQCLESSQDFKSTVPLLGPLTSDLGRFKSPEGFFNPEIWGVDNDSVQKLVLRSIGQCPIDSRRQMWRNIYLTGGVTMLPNFKERLQLELNRLTPDNVVVQVHASWFRYHSSYVGACVLANLESFQRSCVNREEWMSLGDGCLKKMSGY
The following text describes a protein:
Function:
Part of the energy-coupling factor (ECF) transporter complex NikMNQO involved in nickel import. The complex confers nickel uptake upon expression in E.coli; can also transport cobalt with a very low affinity.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTDPSVVHARAPAPDRIGRLGAGVRGLMQHAEEAAGLAQRPGLLQGLDPRAKVAGAFALILAAVATRSLLVLLALFVLATALAAASQISPARLARQVWIVVLGFTGMIALPALILVPGTPVLSLPFGLAITEQGLRAAAFLTGRSETTATLALALVLTTPWPQVLKALRCLGVPRAAVMILGMTHRYIFVLADLALDLFEARRSRLVGRLSPAEARRLATGIAGALFERALALSSEVHLAMLARGWRGEVHLIDDFRFRPRDGGALVLAAAILAGVVWAGSVWP
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MERIESYNTNEMKYRGVRKRPWGKYAAEIRDSARHGARVWLGTFNTAEDAARAYDRAAFGMRGQRAILNFPHEYQMMKDGPNGSHENAVASSSSGYRGGGGGDDGREVIEFEYLDDSLLEELLDYGERSNQDNCNDANR
The following text describes a protein:
Function:
Required for export of phthiocerol dimycocerosate (PDIM) to the cell wall. Essential for normal replication during the active-growth phase of the murine tuberculosis model; Confers a high level of resistance to isoniazid (INH) when overexpressed in M.smegmatis.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPSPAGRLHRIRYIRLKKSSPDCRATITSGSADGQRRSPRLTNLLVVAAWVAAAVIANLLLTFTQAEPHDTSPALLPQDAKTAAATSRIAQAFPGTGSNAIAYLVVEGGSTLEPQDQPYYDAAVGALRADTRHVGSVLDWWSDPVTAPLGTSPDGRSATAMVWLRGEAGTTQAAESLDAVRSVLRQLPPSEGLRASIVVPAITNDMPMQITAWQSATIVTVAAVIAVLLLLRARLSVRAAAIVLLTADLSLAVAWPLAAVVRGHDWGTDSVFSWTLAAVLTIGTITAATMLAARLGSDAGHSAAPTYRDSLPAFALPGACVAIFTGPLLLARTPALHGVGTAGLGVFVALAASLTVLPALIALAGASRQLPAPTTGAGWTGRLSLPVSSASALGTAAVLAICMLPIIGMRWGVAENPTRQGGAQVLPGNALPDVVVIKSARDLRDPAALIAINQVSHRLVEVPGVRKVESAAWPAGVPWTDASLSSAAGRLADQLGQQAGSFVPAVTAIKSMKSIIEQMSGAVDQLDSTVNVTLAGARQAQQYLDPMLAAARNLKNKTTELSEYLETIHTWIVGFTNCPDDVLCTAMRKVIEPYDIVVTGMNELSTGADRISAISTQTMSALSSAPRMVAQMRSALAQVRSFVPKLETTIQDAMPQIAQASAMLKNLSADFADTGEGGFHLSRKDLADPSYRHVRESMFSSDGTATRLFLYSDGQLDLAAAARAQQLEIAAGKAMKYGSLVDSQVTVGGAAQIAAAVRDALIHDAVLLAVILLTVVALASMWRGAVHGAAVGVGVLASYLAALGVSIALWQHLLDRELNALVPLVSFAVLASCGVPYLVAGIKAGRIADEATGARSKGAVSGRGAVAPLAALGGVFGAGLVLVSGGSFSVLSQIGTVVVLGLGVLITVQRAWLPTTPGRR
The following text describes a protein:
Function:
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). Inhibits the type I interferon activated signaling pathway. Mechanistically, mono-ADP-ribosylates beta-TrCP/BTRC to promote IFNAR1 ubiquitination and protect BTRC from ubiquitin-proteasome degradation. Additionally, acts as an antiviral factor by cooperating with PARP12 to suppress Zika virus replication, independent of IFNAR1 regulation or intrinsic PARP enzymatic activity. Instead, facilitates the degradation of viral NS1 and NS3 proteins, potentially disrupting viral replication.
Miscellaneous:
MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Nucleus, nuclear pore complex. Note=Colocalizes with NUP153 at nuclear pores.
Sequence:
MWEANPEMFHKAEELFSKTTNNEVDDMDTSDTQWGWFYLAECGKWHMFQPDTNSQCSVSSEDIEKSFKTNPCGSISFTTSKFSYKIDFAEMKQMNLTTGKQRLIKRAPFSISAFSYICENEAIPMPPHWENVNTQVPYQLIPLHNQTHEYNEVANLFGKTMDRNRIKRIQRIQNLDLWEFFCRKKAQLKKKRGVPQINEQMLFHGTSSEFVEAICIHNFDWRINGIHGAVFGKGTYFARDAAYSSRFCKDDIKHGNTFQIHGVSLQQRHLFRTYKSMFLARVLIGDYINGDSKYMRPPSKDGSYVNLYDSCVDDTWNPKIFVVFDANQIYPEYLIDFH
The following text describes a protein:
Function:
Beta subunit of a guanine nucleotide-binding protein (G protein). G proteins are involved as modulators or transducers in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of cAMP phosphodiesterase. Required for the control of pseudohyphal and haploid invasive growth.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MEISSSPWNDGGYSPYERNRVAVSPFSSALEGEERIETSRSLGDHCFEPLPYVTNYLSIFALFGKEIFGDKGNVSSRNEYLLKKYYSLKKPFVLRHNGHALKNPDMPLQRNDILQTNFMVDKFLNRTVRSVNFNNFKIISDMQSKSGRGTKSGTNQNQSADAIQNICLPSIPSALPYFQYYRKLLTVNTKEWDILKLHSLWVPKLRKDFKDFSLYGDKNSLKPIDSHYDEDNTMKKNLFFERSPSRQTLDGKGCASKGYDISSGNMIIPSLFSEDKLPALTYHCSVELNGNIYIFGGLMPCYSYEEDAPMLNDFFVDGIKNLPPPLLPQVINNPSMVNNPHLYVASIPSCRFSKPKMGGYIPPPLLCVQGSKLTDRHIFFYGGFEIRTETRGDENGKYHLKKRLYVNNTGYILDIMSFKFTKIDIIVQPSKYNAYPTMSSRFGHLQISIDNPNRRASVHSSSMNEIHKMGSASMKQGSSITSGRLEKAAVLSSLPHNTVHTVIIFGGYRQTGDDRYEAMNDLWKIEIPVIRRGKKGYCKFSETANAILLTPSEKDKSDWPEERAFSAFSVHGTSLMDRSSLDMRLLNNLKNHFVLKPSYISQDRVVSPKPVFPMMVHGTHQDLFNSGSAAQESPKAGASASSASAASFDPDMDDNLENYIVNPGRKSSSIPMTAIGRQRLILSQEKPVGKTVVLHGGSNGLNVLDDMWLMDLECETWTPIETFAKADSSEDGDEKLDSVNVGLVGHRMESIGRICVCIGGMVQEDVDQFYSENDDEPPRKRKVDTLPLGGNFLNTIDLSTQCWEEHKITLSKKEDDEDRQDSENEDTNSNIVVGVGGTSLQCDKSIILIGGLISRRSNVKEIYLHGTITKSIFPSVNPSA
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain (120-144) is required for interaction with COI1.
Sequence:
MIIIIKNCDKPLLNFKEMEMQTKCDLELRLLTSSYDSDFHSSLDESSSSEISQPKQESQILTIFYNGHMCVSSDLTHLEANAILSLASRDVEEKSLSLRSSDGSDPPTIPNNSTRFHYQKASMKRSLHSFLQKRSLRIQATSPYHRYR
The following text describes a protein:
Function:
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Sequence:
MKMLRWSMFITLTLLTVLPFLFENGTEASNSASAFVQNAIYSNRITIFSKSYCPYCLRAKRVFVELNEQPFVIELDLRDDGYQIQGVLLDLIGRRTVPQVFVYGKHIGGSDDLSAAVQSGELQKLLKSS
The following text describes a protein:
Function:
Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1. Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
Subcellular Localization:
Cytoplasm, cytosol. Lysosome membrane; Peripheral membrane protein.
Sequence:
MWALLMPATLTRSTLAHEDSSNSQYHSAPNTSSILCQRQSVNTHIGLCHSLLKIPGRPGSVFLLGAKVGSGAERPKPSHCGPQPLGKGGKVGTQGRTWEPFAALAAPARAAAGGGGPGLQPAAPIPLPPMLRSGRGATCCSFSPPGRRGLLPTPPRSSPGSQAPVPRQHPGAQGVHAGLLRTTHPGGPRGPRHVTQGSPAFPLEGCLELQLPAGSVAALRAAPLPEVRVPLPAASGARGVRLSPRRGGPARGGAAREGCSGASWPTMAKPASKDSGLKEKFRILFGLGTPRPNPRSAEGKQTEFIITAEILRELSVECGLSNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIIQGQGERLGVLRALFFKVIKDYPSNEDLHERLDVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVTWDILLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKASGPLSPPTGPPGPAPAGPAVRLGSLPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIMIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPQLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSRIQTSLTSASLGSADENSVAQADDSLKSLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGMNVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFPGSAASPGPQTAPAAKPEKASAGARLPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVPVEPPGLEDFEAALGVDRRTDAYSRSSSTSSQEEKSFHAEELVAGGIPIERAVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGILDGESAAWPASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGRRVERDAFKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIITPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRVGKMGLPRLWGGRLGRAGATPPGLAAQAASAFRSARKPPTPTPACLWCTPHPIPKGLHRLQPSPRLATRWASGSASSPLWRTSPSSCEAGALPAAPALDAILCQ
The following text describes a protein:
Function:
Required for neoxanthin biosynthesis. Probably not involved directly in the enzymatic conversion of violaxanthin to neoxanthin. Is necessary but not sufficient for neoxanthin synthesis. Seems not required for abscisic acid (ABA) biosynthesis in response to drought stress.
Sequence:
MEVKDTNCTSLGYGKPPWIFKGSALYQLHLVKAENARAFIPKECKLVEAFGYTLGGFFLASYDDSPAGIFDELVVIAGLVWNPPTSCAWAARVLVGSDEACLHGRKVVGLPSQVARFSKKITALPQKPESKSSSFLRRIGLRTSSNYKNHMDVEVTEIKKQTAMSICNINVNATASQQDSKGWMGPLIKMSLPNFSGRTKYNSDLLKYSCQIECRVRAVQPAKVSGPSESDADKENSSEDQSSNVESVSRVPRGTKRNFSISVMLSKPILALEFNHLKMRVEAPTTVTACSHDTT
The following text describes a protein:
Function:
Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane.
Sequence:
MNQLRPLARRLALNNTQSLRPVVLPAATSIRFNSTTTAPTDPKAKANAFLDALPGNSAISKTGWVTLAASLGGYAVSNELYVVNEESVILAGFVIMVGYLSTVIKEPYKQWADSVIEKQRSVLNASRTEHTNAVKERIASVSEMKDVVSVTKTLFEMSRDTAVTEHELHKMKQKMAVKDEIKSILDGWVRVETQAREAEQAELVKQVVSSVQKQLEDPKLQKEIMSNSIAEIEALIKDKKI
The following text describes a protein:
Function:
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MRVLSLFLKDFRNYTDLRLELGPEMNSIFGLNAQGKTNLLEALYILSLGRSFRTSRLTDAIRFGASHFFIEAVFSHKEVFHTLSIQVDKKGKKILFDGAPITKLSELVGLFPVILFSIKDIAIIEGSPSERRRFLDLLLAQASDKYTEHISLYHKALDQRNASIKAQNQKAISAWNSPLIAYGSLVAFLRNECTKKLNTIFQTLWDNTLKETLSLRYESSLITEESPTLNDIASNYYEQLRIANTKDLDLGYTMVGPHRDELLLTINDLPVAKFSSEGQKHSLLAVLRFAECVYLQEEFCIHPLLCMDDIHACLDQQRLDQLLQLSNSLGQVVTTSTICPDHRSTTSCIFHVTQAQVSLVAPQSL
The following text describes a protein:
Function:
Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, acts as a virulence factor by suppressing PCD and HR-based plant immunity. This function requires its E3 ubiquitin ligase activity probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. Also, induces expression of host genes involved in ethylene biosynthesis and signaling, in particular ACO1 and ACO2, encoding the ethylene-forming enzyme ACC oxidase.
Miscellaneous:
MISCELLANEOUS: Unlike many effector proteins, it is widely conserved among diverse genera of plant pathogens including Xanthomonas, Erwinia and many strains of Pseudomonas; MISCELLANEOUS: Acts as a general eukaryotic PCD inhibitor in plants and yeast.
Subcellular Localization:
Secreted. Note=Secreted via type III secretion system (T3SS). Localized to the plant cell cytoplasm.
Sequence:
MAGINRAGPSGAYFVGHTDPEPVSGQAHGSGSGASSSNSPQVQPRPSNTPPSNAPAPPPTGRERLSRSTALSRQTREWLEQGMPTAEDASVRRRPQVTADAATPRAEARRTPEATADASAPRRGAVAHANSIVQQLVSEGADISHTRNMLRNAMNGDAVAFSRVEQNIFRQHFPNMPMHGISRDSELAIELRGALRRAVHQQAASAPVRSPTPTPASPAASSSGSSQRSLFGRFARLMAPNQGRSSNTAASQTPVDRSPPRVNQRPIRVDRAAMRNRGNDEADAALRGLVQQGVNLEHLRTALERHVMQRLPIPLDIGSALQNVGINPSIDLGESLVQHPLLNLNVALNRMLGLRPSAERAPRPAVPVAPATASRRPDGTRATRLRVMPEREDYENNVAYGVRLLNLNPGVGVRQAVAAFVTDRAERPAVVANIRAALDPIASQFSQLRTISKADAESEELGFKDAADHHTDDVTHCLFGGELSLSNPDQQVIGLAGNPTDTSQPYSQEGNKDLAFMDMKKLAQFLAGKPEHPMTRETLNAENIAKYAFRIVP