The following text describes a protein:
Function:
Component of the NuA4 histone H4/H2A acetyltransferase involved in transcription and DNA repair.
Miscellaneous:
MISCELLANEOUS: Although strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, suggesting that it may lack such activity.
Sequence:
MEDGFEKSLSSSIELLKAESTEIEEKIKLTKILITKVSSISSDASQLYAELIPLLLDFLRNTEVNLYRNSSVNELKIEALTLIQSCAHRDEFKQYAQSCVLSFISLIKADNEEVAVFCLKVIMDIFKTFKFCIESTAQPFFDLVLELSTNLPYLIPSIFVENPKSNEEENTTLAFGSYLSTETSIIQQRVNSLAISTQPLELASQSFRVYVECPVIIVLILQAYRQAAFPGVQAIIPCFLKMVQIDVPIDIASYAMIEKDSSIDFIEFIRNKYQYRNFFMAQVKTLSFLAYILRTHPNTLSEKDIIPDIVIKLLRRCPFDMCFARKELLVATRHILSTNLKSLFVKKLDFLLDLNILLGNGVGTQKLLRPLAFSTLADLLHHVRDELNETQIRKSIMIYSTNMHDLTLSIGLQTMGARLILNMVDRMISLPSIPDAIFLLLSIFDSFVNKFSELNDSLDQFFKKKYEEEIKETKSPTRSSPRDLSSFSTSVNDGSFLFKNLMFGLRALMYGLRTCKSRCIEIGGEQFSGFLTNIKPFEAVTFQKLFFEVGKGFSYFRPEQVYLETFFCCEEESLDRPAISTLPRNKDEKDCLEVFATIFIHLEPSIFLKVFETNLPTFFDQLKKNLTLFHIPQFLLSNESTSSKFLNILLRFLLSRIEELGSSDIRHGSVLLRLFRLSFVTVSMFATENEPVLRPYVSEIIVKCMKLAPNSANSLNYYYLLRALFRGIGGGRFESLYKEVMPLLHALLEAFNSLLISARTPKEKDLFTELCLTIPVRLSLLLPYMSYLMRPLVMSLKSSQELVSQGLRTFELCLDNLTPDFLDPIMAPYIEDLMNALWSHLQPLPYNYNHSHTALKILGKLGGRNRKLLDRVQSLKNSPEPNNDFTLLLSIKGVKQPQLLHYTQYVDEAVNLLSSPSSDLEVKQQAFTYVCNISKLYVYKSDATNSLASSIRCTADKISKSNFDFRRPYSVIPSRMTGRSSFTQLSDDSDETIILASATYGLFFATTVDELREEAYFWLEKLAVNVIVHDIFYAFDVIQGNHSKFTTNLQKEVIISPHYFAHCLSEVVCNDNSKMGDAVKHVLKFMFSFLESIFENPERAFILPIFEVLLSDFRHKCYDPHWYKKYGGCFGLECLIEQDHSSKWLFDRQVDILTALFFTLKDTTSEVPTVCKDHVMDVLKQLFRKIYASKDTEIAPGILGHLVLELSNHNSVVRSSTQKLLSLLSELSNTPIVKLVSPFKERLLSPIFAKPLRALPFHIQIGHIDAVNYCISLGSELITFSDELIRLIHETTALAEADDDALIGIGKTSHFKNAALLIRLRVVCVELLSTCILKIDFNNPQHAHLREGIIVVFFKSLYAKSKELIEAASLGLKNALQEDQKLSKELLQTTLRPILYNISDYRRLSVAGLEGLGRLLRLLTNYFKVEIGRKLLDHLKALLENVDFQKVSSLPLFCQTEMKIVRALIDLFHLLPNNANRFMDELLICVVEFSLRLQRTFPNYFSEPLLKYVNRYPEDAWKFFMVRYDEAAFTSVFVELLRLKDSDPLLSVVKDNWLFFQTILTNEINTVTANRYSFALDSAIVILQRDPSFFKDKNDFFRGSMDAVLAISHLVENESILESMVFWNDLLVRTSTFLLEVYDLCIYNYDDGLKLLSCFHMYKNSLAKNLVSDLTAHLVKKIEEPDLENNVKLILNLILSKDYGFLLKENLAGILLTYLNQNVSSLEKCNQIFSIFYEVFFQHPSTNVYANDEGIKIGALQIISFFLKNVPEITVQHQTEMLKMCSLFGNSEDVMIKQLSIYVMSLFILRSQFPYELVNVVYMALLKSSPIEVRHLVKSSFDNIFSYIFSEEPESKKSPIWFELPLQVISSQSQNISQLLNVYDFISSHSDIFIEHRGRYVPILIDSLYKFGAIPNPNPEIRALSLGLIKVLLEWNDLQLKVDQKEIFSNNQKRAILSYLFRFVCLFSEPFTEGLCSEAISLLERLLSSGTWASLGMKLSFFTKSITHFDATDANSVMFANSLRTLSIVVGHSDSAWIEENLSDLKFLLEKSLENESVGVQSAIGNFVSTILTLSNTHPSIAGNPIFNDIWTSIASWTERRLQSCSQIEVTLPCVECFFKYKKDALHTLLPGFMRCFHKVAKEFLSLGSQPSGNSLNLQIVNAVDERVSILKSMIELGCSYISYLGDQRRWFLSALVQIIEKSSSYEICNYLLEIVRGWIMNSPVPVPTVKEKAALLLKMVTFEGRFSQNEQNDLFNKYLSFIADIYEMEPYKNSELTFRLEAVYLLGTRVANKKLKERFIKGLNSSFPSDLFSRFQFLLGSQHWESLSNTYWIVQLNIFLSRCFDLNQRCQFYKKPKLFSCFSIYCREFDEDLTSQAQDTEMLHNNLLKYGIIDFNQNSMLVSDFVLPVLSLQFSNSKIAEYLWRDFFNASVCSFTKDEIPLCIGSIISFLSREYHIRLLGKTPNVLETILTSIVSSDMPIPLPPHLLVYLSKTYGLHHYCILLLENSLQNNPGLSEDELTVYHKSCLDALSDIYYSLDEHDLYHGLWRRRANFLETEVATSHEQCHEWEKAQLVYEHAQLKVCTGSLPYSPTEHGFWLDHWILCAQKLNQWDVLFDFSKQEGCAELYLECAWRLSDWSTEQDTLEKATKSLSPFTSLRRHTADALLYLNKTQRKMGSVTEFSRIIDECMQFSLRRWQQLPKRVYQSHVSLLHHFQEIVELQEAFGIYSQLNDTNIHNIDNKLRDIKVVLQGWRERLPNVWDDIDIWSDLIAWRQSVFKSINKVFLPLVSIAQQSTNKSNTNSVSYLYRGYHELAWIINRFAHVARVHHLPEVCINQLTKIYTLPNIEIQEAFLKLREQAECHYESPSEMQLGLEVINNTNLMYFRNRQKAEFFTLKGMFQNRLGEKDEANQAFATAVQIDIGSGKAWSEWGLYHDELFQANPQEIHHACNAVSCFLQASSLLSSSNSKPLLTRVLWLLSVDDSHGSVSEVVSSFKSEIPTWNWIPFIPQLLSALSHRESIHARAILIQIAKTYPQSLHFQLRTAYEDFLMLKKQQAANVLRGNSRLRENDSSSDNKSKDLSPSGSFSSVSQFNSKNGSPSSIDSSEKHQISTVKPAWELIADVTSILKTAYPLLALTMETMVDQIHTRLKSFPEEDAYRLIVALLNDGLQYISRLGVVSKNTFQLPMSQANIQRFAENVLPVSVREAFLRDFVETKLDLLTYVDKLRMWRKKFENILDQRPKFLHLEQCSLYLSEFQHQKFDEVEIPGQYLLDKNNNNDFVRLERFVPNVDLVRGHTMCYKRLTLRGYDGKLYPFALQYPATRHSRREERMLQLLGTFNTVLRSKIEIQNRNFSFQIPSSIPLSSHMRIIADKPSYVTMQTISDEYCKNRGMPLDYGIRFYFDRLQTGLIQLKRASASMLSNSTVEEKKQIFRQRALQLRMQLLETLNSSVFPESIYYDYFYKTFERYCDFWFFRRTFTTQYAYMIIMTYVFNIGGRSPQKLFIVKDSGQVMSQDLLPSMTSNQPVFHNTEAVPFRLTPPIQYLISDLGVEGLLSGLVMSIAQSLSSPTTDIKQYLSLYVRDEVFWWSKQQRKPIPQGIQLFETVKVNVELLFRRISVISHNVPEDLPLNQTLVDLVSQATNPQQLAQMDQLWQAWL