lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MASSIVVMLAIIARLAYRASGTANEAVPAYHTLCAVVNIARGEPTTPEDTEGAAISQEITLLTELNITVADDDFYNQDFKEDPNNKITEANWVKHRAAWHAAKKNLQNNKVEKHGLKITRPLNSHARQAAAVVINRTLEMALERRKDYKPLKKTGVEEALLTALYGPTEALSQKAGETFGASGVNACSAPGSGTAVPGMSLASDLVCMFGSNSGSNKAEECLGTQGGQDCQYNDQSGAHTCFPQLLAGFPAAGKAKVSAAAIQAAIGAFITGLKDKGGSTQANNLILGTANSVNCNGVANAGCVKYKATSTGTVPIPWMRHLETAATKLAEHAEQRSKNMASLAEIRHLRSIAIQEYLKALKGDQPQLQKIAGDQTAHPKKKEPECNKHQSKTECTEPCKWNENATDASKKCSLDPQKAKEQAAGTEDGAAGEQKTDSKCSEKKKQEDCKDGCKWEDNKCKDSSILVNKQLALSVVSAAFVALLF
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
Sequence:
MQFDGRSGGEGDAEGVQGAGAAAVNTPSIVSDDELMALEKRESLIVLQDAVWSVSSAKHGNGVMCLLDGSHNTFWQSDGVVPHVISIDFALLKPVAAVALYLDCAEDNSYTPRRMRVQAGTHNGDMADVATVTVDDPRGWVLIRMQTEAETPSSWNTPAAHSDDAKADIENDMPLDNADFEEFIQDGVWCTRVRVIVEENRQEGRDCHVRGLRVLGHIKQSLFTTASFTQNLHLR
The following text describes a protein:
Function:
Probable plant-specific actin binding protein that bundles and stabilizes microfilaments (MFs).
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTKVCPEIEDMTLPEPVTTVSADVSFASNHFPSYKLGPDNQIVEEPKEDDKGPSVQDTVEKESELLSDQHKRLSVRDLASKFDKNLAAAVTLADEAKLKEAASLEGHVMLKKLRDALEYMRGRMDGQNKEDVEKAISMVEALAVKLTQNEGELIQEKFEVKKLGNFLKQASEDAKKLVNHEKSFACAEIESARAVVLKLGEAFEEQERSSEASRAQGPDVEKLVEEVQEARQIKRMHHPTKVMGMQHELHGLRSRLQEKYLNSIKLHQEIKRVEESKSCPFVLEGTQSLGSCLRIHVSSDDAIDLSNCSIQWYRAACETSRREAISGANQSVYAPEPFDVGRILQADIISNGQKVTVTTDGPIDPDSCLQTRVESLMRKSNSEFNVVISQMNGQDYASRTHVFTVGKTRIKLSRGWITKAREIYSTSMQLCGVRGNIKAPARALFWQPRKSLTFILTFESEQERNTAIVLARKYAFDCNVTLLGPDD
The following text describes a protein:
Function:
Required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. ATG14 mediates the specific binding of the VPS34 PI3-kinase complex I to the preautophagosomal structure (PAS).
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=TRS85 is required for the recruitment of ATG14 to the PAS.
Domain:
Coiled-Coils at the N-terminal half are essential for interaction with VPS30 and VPS34 and autophagy.
Sequence:
MHCPICHHRAHVVYCAHCINTSPSLLLKLKLDLILLKDENKELNGKVEQILNEAMNYDQLDIKRMEKKKDPLMNSLMKLDVLRMKKNNNLIRHRIEQLNERIYSKRNHISELKVEIDNYKCYKVGTGTDKLREQVEISDAKNKLAQVSKICESARDYKLNLLNNWFVIQKLQDNFQIPFAIAFQPLISLKNFRILPLAITNDSINIMWKYISFFSDILMIKLPYTNKICEQPMFEFSDSIQTVVQRLIKLIINILQICRHLKLVPSTPMDIPWLLDQYDVDGLFYNMVKRNKMKCRSVSLYWTFGMLYSMVLDNMNNPQRGHPARRTAPPPTVTGPHDRWYVVG
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.
Sequence:
SEVQGMKNLPYFCRGEVIRGFGRGSKELGIPTANFPDSVVDNLPADICTGIYYGWACVGNGDVHKMVMSIGWNPYYKNTKKSMEAHIIHTYKEDFYGEMLSIVIVGYIRPEKSFDSLDALIAAIHSDIEEAQKRLDLPDCRKLREDNFFRTSANQIMNGH
The following text describes a protein:
Function:
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MAIRPSYGSLGQGSWGGPRGAPLPGPSSPKKLAACQLVLFASCCLLLQEQSCVAAVKVNCSRPDTYSLYTVLNTALNNSALRPVISLKTPTNVNVSFTLYSILGVDDKQQVLTTFIWQVLEWDIEYLSWDPEQCGTERVSLPRVMIWVPDILINEFMSDNKSPQTPYVYIDHTGHVYDDRPLRVDSSCSLDIYNFPFDVQICSFSFGSYLHYASDVTISQGQPVEYILEESLNVMQNTGEWELVNISVMDQTLLTSNSTYDMVVYNLTIKRRPMQYVVNLLIPSCFLITVDLFSFLLPPESVDRSAFKMTLILGYTVFLLIMNDLLPDTGSTTPLINVFFSICLALMVASLLETVLITNILYSSGQYPNVPRWIRILVLQYLSRLVLLPQKTSQSNRVTVFLNPGVQDVQVVKSLEGGGNVPCQTPESQLDRAAVELLKRLSRDLQAIRQHAEKHFKSSDSSEEWCQIGHILDRLLFAIYVVFICGSFIVILAIWNKAVLKSERA
The following text describes a protein:
Function:
Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. Involved in pollen tube growth by modulating Golgi morphology and vesicle trafficking homeostasis leading to the deposition of cell wall components and proteins at the pollen tube tip. Required for sporophytic development.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MAMEVGEMSQPEATASLLSLASATQQPYVSELLSFTLDRLHKEPELLRVDAERIQRQMQEVAVGNYRAFITAADALLAIRQEVSSIDKHLESLIGEVPKLTSGCTEFIDSAENILEKRKMNQALLANHSTLLDLLEIPQLMDTCVRNGNFDEALDLEAFVSKLATLHPKLPVIQALAAEVRQTTQSLLSQLLQKLRSNIQLPECLRIIGYLRRIGVFGEYEMRLQFLRCREAWLTGILEDLDQKNAYEYLKGMINCHRMHLFDVVNQYRAIFSDDTSGSEENYDGGLLFSWAMHQITSHLKTLKIMLPKITEGGSLSNILDQCMYCAMGLGGVGLDFRGLLPPLFEEAVLNLFSKNMSTAVENFQLVLDSHRWVPLPSVGFPSSGINEDSKDDVTPPSYLMEHPPLAVFINGVSSALNELRPCAPLSLKNVVAHELIKGLQAVSDSLLRYNTTRMLRLSESNLFLSLCRAFVEVVFPHCATCFGRCYPGGATIVMDAKSAYEGLGRILAASSSQEPSNKSPKVISTDTKDASENGVASQPEEKQAENPNAKEEDNSPIPLQTPEITPES
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MVRVARMKLHLKIHDGYKPHVCEVCGRGFANKSSLKVHSRFNHLGVPKPFMCSTCGHMCSNKKTLEIHEMTHTDARPFSCSICDKTYRSKANLKKHKRSHTGEKPYTCTVCSKSYSHRYLHLPNNFPRHHCEVCQQKFCRVLAFERHRATHTGASVGVPCGQPDCDFMYSSLKELKEHLIEHHPEKVFHCELCDKVFLTQLNLTLHQVTFTLAKCQQCNKTLKVSSMKNHLKSHSGVKSHLCELCGRSFVFKSSLNSHIRINHNGEAKPFMCTICGHTCSRKQLLDDHERIHTNERPFECSICDKRFRTKSTLATHRRTHSDVKPFSCKICAKSYTQSTSLKKHFRRHHENTGPNGAKNPLIAFAKLSYHCEFCQKQFWRLLTYEKHRATHTGEAVAVRCAHPNCDFTYSDTQQLKTHVLTQHPHKAYTCDVCEKIFLAKHSLKDHKILHDSTLGFQCSYCPARLTTKANLISHEKNHTRDTPFECSYCEMRFYSTYMLNIHMRKHHLLGQPKKKRIRKPTGK
The following text describes a protein:
Function:
Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MIKYECVIKLYVNTFKGFEEIDEEKLKEYKGKYVIWFDLFNPTEEEIEFLRKQTGFSMPPKEILGDIEISSKYIEDKDYLEVTLSFVIPQKEEILVEPVVFYIKEKFFVTVRYRDIPSIMIFKNRTNFQRKFFQFPESLFAEILGIEVDRIGDRLELLGNKIKDIWRQMFVEQSEEMIRELAFYDELNITLRESINEKIRIITKALKSPLINAHTKKELRIIYEDLTTLLEYTSFYMEKIDSIQNSLLGLITIRQNEAVKVFTVLATIFLPATLIASIFGMNFKHMPELHWKYGYPYSLFLMVFVTLVLLFWVRRKGWL
The following text describes a protein:
Function:
Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling.
Subcellular Localization:
Cytoplasm.
Sequence:
MRLVILDNYDLASEWAAKYICNRIIQFRPGQDRYFTLGLPTGSTPLGCYKKLIEYHKNGDLSFKYVKTFNMDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNATDLQAECDAFEKKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCDEDATLELRVKTVKYFKGLMHVHNKLVDPLYSMKEGN
The following text describes a protein:
Function:
Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.
Subcellular Localization:
Secreted.
Sequence:
MLRAVLLPTLLAFGAFTPVHGANSPGCGKQPTLTNGVNQINGREYVLKIPDGYDPSKPHHLIFGLHWRGGNMYNVVNGDSIQPWYGLEARAQGSAIFVAPNGLNAGWANTNGEDVAFIDAIMEQVEDDLCVDQASRFATGFSWGGGMSYALACARAAEFRAVSVLSGGLISGCDGGNDPIAYLGIHGINDPVLPLDGGVTLANTFVSNNGCQPTDIGQPASGSGGSVRTDFSGCSHPVSFIAYDGGHDGAPLGVGSSLAPDATWEFFMAA
The following text describes a protein:
Function:
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MFEVTVSKRLLKSGIIVSAMTLISRVLGLVRDVVVANLMGAGASADVFFFANRIPNFLRRLFAEGAFSQAFVPVLTEYHASGDINKTRDLIARASGTLGVLVTIVTLIGVLGSGAVTALFGAGWFLDWLNGGPAAGKFELASLLLKITFPYLWFITFVALSGAILNTLGKFAVSSFTPVFLNVMMILCAWYLSPNLEQPEVGLAIGVFLGGLVQFLFQLPFLIKAGVLVRPKWGWKDPGVVKIRTLMIPALFGVSVSQINLLFDSFVASFLQTGSISWLYYSDRLLEFPLGLFGIAIATVILPALSRKHVDAHSDGFAHTMDWGIRMVTFLGIPAMLGLMVLAKPMLMVLFMRGEFTPSDVEQASYSLLAYSSGLLSFMLIKVLAPGYYSRQDTKTPVRYGIIAMVSNIVLNAIFAWFYGYVGLAVATSMSAFLNMALLYRGLHLQGVYHLTRKTVWFVARLAMAGAVMTGALLWQLDTMATWLSWGISQRALTLTGLIGLGVASYLAILLLLGVRLKDLKAATE
The following text describes a protein:
Function:
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular Localization:
Nucleus.
Sequence:
MDQQGQSSAMNYGSNPYQTNAMTTTPTGSDHPAYHQIHQQQQQQLTQQLQSFWETQFKEIEKTTDFKNHSLPLARIKKIMKADEDVRMISAEAPVVFARACEMFILELTLRSWNHTEENKRRTLQKNDIAAAVTRTDIFDFLVDIVPREDLRDEVLGGVGAEAATAAGYPYGYLPPGTAPIGNPGMVMGNPGAYPPNPYMGQPMWQQPGPEQQDPDN
The following text describes a protein:
Function:
Catalyzes the hydrolysis of inorganic orthophosphate from phytate.
Sequence:
MPRTSLLTLACALATGASAFSYGAAIPQSTQEKQFSQEFRDGYSILKHYGGNGPYSERVSYGIARDPPTGCEVDQVIMIKRHGERYPSPSAGKSIEEALAKVYSINTTEYKGDLAFLNDWTYYVPNECYYNAETTSGPYAGLLDAYNHGNEYKARYGHLWDGETVVPFFSSGYGRVINTARKFGEGFFGYNYSTNAALNIISESEVMGADSLTPTCDTDNDQTTCDNLTNQLPQFKIAAARLNSQNPGMNLTASDVYNLMVMASFELNARPFSNWINAFTQDEWVSFGYVEDLNYYYCAGPGDKNMAAVGAVYANASLTLLNQGPKEAGSLFFNFAHDTNITPILAALGVLIPTEDLPLDRVAFGNPYSTGNIVPQGGHLTIERLSCQATALSDEGTYVRLVLNEAVLPFNDCTSGPGYSCPLANYTAILNKDLPDYTTTCNVSASYPQHLSFWWNYNTTTELNYRSSPIACQEGAAMD
The following text describes a protein:
Function:
May be involved in environmental stress response.
Sequence:
MGTPEFPDLGKHCSVSDCRLIDFLPFTCDRCNQVYCLGHRSYIEHNCTKPNKQDVTVVICPLCAKGVRLIPDQDPNIVWEHHVNTDCDPSNYEKATKKKKCPVPGCRETLVFSNTIKCRDCEVDHCLKHRFGPDHKCPGPKKLETSFSFMSLWNMSSGKEVSKPNLSSTTSSKWTSSLLDMASKLSGIGQSSGSGTSNNQLEKCPLCDAKFSSAASLVDHAKKVHQRSGGNQYGAKKVSISACPKCSKGFLDPVSLVEHVERDHGGCS
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Sequence:
MAERERIARAFVLLLAVQAVVLLAQGKSCRHRLADHIRGVDKWTFDPPKNIYGKERNVHKQKSSLIVQDFKGNGTSSQSPAWIWANNDIEAGINKQINRELFAHYTYLSMAAHFGRDDIHLPGFAAFFKKAAEEEYTHAHMFMEFLNKRGGRVKLHHIMKPCRDHWGNGLMAMRDALYLEKEINHALLDLHQVADTNRDPQVQDFLESNFLGEQVDSIKTLANYVSTLQRLGGGLGEYQFDKETLGAK
The following text describes a protein:
Function:
Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair as well as from single-stranded DNA.
Miscellaneous:
MISCELLANEOUS: The 4Fe-4S cluster may have a structural rather than a catalytic role.
Sequence:
MDLQKLHELIKNCDKCPLHKYRKNAVPGEGEMKLGVMIVGEAPGASEDEAGRPFVGAAGQLLTEALSRLGVRRGDVFITNVVKCRPPNNRTPNREEVEACLPYLIQQIGILKPRRIIALGLISAKALMELMGRRAEKLGDVKGKCYQGRIAGVQVELCITYHPAAVLRKPALRGEFQKDLAMFFGGGLDRFLDPSK
The following text describes a protein:
Function:
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Miscellaneous:
MISCELLANEOUS: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
Domain:
The Walker A ATP-binding motif also binds Pi and PPi.
Sequence:
MNTSITARELFDQQRDKLALRWVAGQKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLRAAADESNTPLWISPKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MLNQVAVEAIYSATYLENYLDSVENLPNDLQRHISRMRQLDVDFQAILRDIEHYSDVIQRGPEAQESQVDSGDEKPSGSGLTASSGGNAGHWRKRLLQKVQSALISSLEIGDEKLQLVQTVQDVIENKSRQLETDCKALEFSKDRESVECAKDNTTNTRETSSATGGNSGNTGERTKRARRARPDDRDSPVPTTPVNVGVSQRKTSNAANSTAASSVAKKKKRRSGRGNEREKERSASPQEMPIDPDEPTYCLCDQVSFGEMIGCDNDLCPIEWFHFSCVQLTTKPKGKWYCPRCRGDRPTVMKPKAQFLKELERYNKEKEEKA
The following text describes a protein:
Function:
Facilitates the differentiation and the cornification of keratinocytes.
Miscellaneous:
MISCELLANEOUS: Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAKRPTETERCIESLIAIFQKHAGRDGNNTKISKTEFLIFMNTELAAFTQNQKDPGVLDRMMKKLDLDSDGQLDFQEFLNLIGGLAIACHDSFIKSTQK
The following text describes a protein:
Function:
Sterol O-acyltransferase that catalyzes the formation of stery esters.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTDTPRILITPSPLSDISTTINKPNVHPSMSLLKALPECRLVVKSKGDKNNANVVEFPLDRHKQLLIAGKVYHDYKFKPRKSIFDRVTDPNYFAKSEFRGFYVLFWLSMAAWVLQLYARSYWQRDTLLGLPLARQVFRQFFVLFSSDFLMICLSFFSYGLQVCIEKNMIRWANLGYTIQTLWQGFYMVLAVYWVKHRDFPIVQCVFFTLHCAVLIMKQFSYSHHMGYISEIRILHNEYEKLLKFVRECLNSTEKDEKYTFELTFPNKPAETISTLQAEEIVALTAKYLSRQMRSEVGNVVYPDNINFFNYVDYLLVPSLVYSMEFPRVAHFRWHYMAFKAGSTFGLLALTLALVDWYFVPSAVAVKDLDFIGKLRIAPLLMNKIMFPAIILYLIMFYLIFDCILNAFAEITKFADRGFYGAWWNTVTWDEFSREWNKPVHVFLMRHVYHSSISGFKLKKSHAVLLTFLISALVHEFVMLLATGKFRCYILTFQLLQIPLYDLQQMFAFKKRDILGNVFFWIGMFTGPSFLCILYIVF
The following text describes a protein:
Function:
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLFRLLIVLPVLAVALFLYGAIVSIGYIEENRCRMTYMFEHPQYTRLPVQGNERFPKYGLYAYSEGFVTQRVQQRLFTGAPVLFVPGSGGSYKQVRSLASVALRKGLDNNWQAHLDYFSVDLNEELSGVYGGYLQDQTDFLDLCIQEITRLYGARGRTTRLFIVGHSVGGKLAQAVVGARTSIGRHVAGIVTLSAPVDKPVALFDHYHYSFYDRIEQAWRTNRSLAGAANASPSHGLLPLDGILFVTIGGGIRDIIVHDGLTASRYADLHAMTHNIPNVWLSVDHLCAMWCLQFVLVMNRFLFSMIVPQGRGSWGFVEGKQHQLELATRFLAQPFRSDDDDDDDDDEGNNHKRLPAGSAKQPLIQHHPEQEDWIEDIRRSFTERHRAGIDRTRVQMIRLVPEKLAHRFVRIEVINSEQSNWLSGCAAVEVYGNSRMCQKAISLTNYTLPVPSSKFDRFGALLDLHELKRANPRWTHVLVKIPRTTKPVQFSVDVFNPDERAINVTMPHWFDYRARTILQDASPDDSYYRISVSGMTHTYQTIALDLTAVACDGVRGTVVVKVHVAWAPGYDRYAFHEELNQTTVYIYPPIEKPPAGEPDVPIQLDVHLTPGCKYRIRYAQSLRVSMARMVQQHVVLIPAHLVALLLLAFKDQLTQTPADDPAFVVGKLRSSLTKPGPLLMLLATGSLTAKFLALFKAIPPTETVATPLAVSILVHLVALGVLVLATLALWGAIAFCANFAHKIILRLIALPIPVMSSTFLSCIHKFPLAIAVLLVAIALTACGGVSLLCAAAVYFVLLSKAYEDYLENFVFNTARKIAARLFGARERPHGEGSRAGRKRNRRRTANETGDELMVINFHLPLFLLVILLALLNVPSVITWAKNYHYANTLQPDPSLVPALAVLVCLAVLWQLNTPRNVCGYELLSALLVIGAFVSVLYCQVHVYRLNYLLALVFVAITVHQIIAPKRREVGEGGEQEEEADDGKEAVEGVEQAEHEEEETGDKKAN
The following text describes a protein:
Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSDKPNMEEVTSFDKTKLKKTETQEKNPLPSKETIEQEKQAESS
The following text describes a protein:
Function:
Involved in translation regulation. Inhibits protein synthesis and decreases bacterial growth when expressed in E.coli. Can also stimulate macrophages and peripheral blood mononuclear cells (PBMC) to secrete important cytokines that may be significant in granuloma formation and its maintenance. Increases secretion of IFN-gamma, TNF-alpha, IL-1 beta and IL-8 through human Toll-like receptor 2 (TLR2) signaling pathway.
Sequence:
MEPKRSRLVVCAPEPSHAREFPDVAVFSGGRANASQAERLARAVGRVLADRGVTGGARVRLTMANCADGPTLVQINLQVGDTPLRAQAATAGIDDLRPALIRLDRQIVRASAQWCPRPWPDRPRRRLTTPAEALVTRRKPVVLRRATPLQAIAAMDAMDYDVHLFTDAETGEDAVVYRAGPSGLRLARQHHVFPPGWSRCRAPAGPPVPLIVNSRPTPVLTEAAAVDRAREHGLPFLFFTDQATGRGQLLYSRYDGNLGLITPTGDGVADGLA
The following text describes a protein:
Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular Localization:
Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.
Sequence:
MTIYAFYIYSRKCECVFAHRWKPSDRNSMETLVSQLEQNSIEDDMEKLIFGVVFSLRNMVKKITADQDQFMSYTTSKYKLHFYETPTNLRLIFITNPKIDSLTHVLQQIYTTLYVEFVVKHPLYTHVPPSAEEGGINCEIFRITLDRFVRTLSCF
The following text describes a protein:
Function:
Protein phosphatase that modulates defense response to pathogenic bacteria, conferring resistance and promoting salicylic acid (SA) accumulation.
Sequence:
MGYLNSVLSSSSQVHSDDGPVSGGGLSQNGKFSYGYASSPGKRSSMEDFYETRIDGVEGEIVGLFGVFDGHGGARAAEYVKQNLFSNLIRHPKFISDTTAAIADAYNQTDSEFLKSENSQNRDAGSTASTAILVGDRLLVANVGDSRAVICRGGNAIAVSRDHKPDQSDERQRIEDAGGFVMWAGTWRVGGVLAVSRAFGDRLLKQYVVADPEIQEEKVDSSLEFLILASDGLWDVVSNEEAVGMIKAIEDPEEGAKRLMMEAYQRGSADNITCVVVRFFSDQAGGIGSSSTNIPIDHGIVPDRISGDSST
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using mono- and dimethylated H3 'Lys-9' as substrate. Acts redundantly with the methyltransferase met-2 to position chromosome arms at the nuclear lamina. Required for small-RNA-induced H3K9 methylation. Together with met-2, protects and stabilizes repeat-rich genomic regions by suppressing transcription-induced replication stress through methylation of H3K9. Suppresses transcription from various repetitive genomic elements through methylation of H3K9; exposure to moderately raised temperature reduces methylation by set-25 leading to de-repression of transcription of repetitive elements lasting at least 3 subsequent generations, despite culture at lower temperatures. May play a role in transgenerational transmission of environmental information.
Subcellular Localization:
Nucleus. Chromosome. Nucleus lamina. Note=Colocalizes with its own product and hpl-1 in foci in the peripheral region of the nucleus, in a manner dependent on H3K9me3.
Domain:
The SET domain is not required for localization to nuclear foci.
Sequence:
MLPAWGTSTEATASHAGWDGDDEGDIRAAYTEDEKKENIPPISLTSVSTNGAYPGQKRRRSESVRTLKPECPPEETQRLRQRRRISATDATQSSRTMNVIEDRKPRVNRARKSQDAPSTSTCGFETPVGTKRKSKAADSQKPPKQSKLRKIDEASTSKAVDNSSKDGKKTTKPAVTQSNRRRSGLSLRPVPIETIFSESSGRESSTEDEADVSHQQRVEKIAKNPIMVVVLPLGPGNYPNNERITVVSTYKSRVNKNCNEARRAQRHGSWSRKGIAFPGIPTKKFTKSDLAKYGAHASNWPAQAAFRSEEGKILIYYEGWTCLTLHRLSVEECARTAPTILEEMSIRDKFIETVKSAAAEEAKLVVEKNQENGIELTLDEALKQIFIEPVPQSSPENVFWIYQDLSYFHTMDNRDLGLAPVFYISSYTQSVRPPCYAYTAINIVDVDAYKRCLESRANMSFADLTGQKIWMPTRSKACENGTKCKCDARFMFLYDPHDVTNLECTPDGKVDFTDFKIDNARIVMECSDACGCSLDCPRRSLQRGQQHPLAVYYEGPEKGFGVRAAANIKAGELVCEYTGDVTLLPTSDPVASSSTKTDDGEEQENPEAPERVDSSYDAAFNAMDTKIIISAKKTGNISRFINHSCDPSSVFVEVYSRRFEEDPLIPRVAVYAIKDIALGEEITIAYYEPGIEWKRSSVKCRCKSTKCMGTLPAF
The following text describes a protein:
Function:
Binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MLPLSLLRTAQNHPMLVELKNGETYNGHLVACDNWMNINLREVICTSRDGDRFWRMPECYIRGSTIKYLRIPDEVIDMVKEEVVSKGRGRGGGGRGRGRGGPGRGGAFGRGGGRGGGRGDGKRGGRGGPPKS
The following text describes a protein:
Function:
Probably plays a role as positive regulator of autophagy.
Sequence:
MASISEPVTFREFCPLYYLLNAIPTKIQKGFRSIVVYLTALDTNGDYIAVGSSIGMLYLYCRHLNQMRKYNFEGKTESITVVKLLSCFDDLVAAGTASGRVAVFQLVSSLPGRNKQLRRFDVTGIHKNSITALAWSPNGMKLFSGDDKGKIVYSSLDLDQGLCNSQLVLEEPSSIVQLDYSQKVLLVSTLQRSLLFYTEEKSVRQIGTQPRKSTGKFGACFIPGLCKQSDLTLYASRPGLRLWKADVHGTVQATFILKDAFAGGVKPFELHPRLESPNSGSCSLPERHLGLVSCFFQEGWVLSWNEYSIYLLDTVNQATVAGLEGSGDIVSVSCTENEIFFLKGDRNIIRISSRPEGLTSTVRDGLEMSGCSERVHVQQAEKLPGATVSETRLRGSSMASSVASEPRSRSSSLNSTDSGSGLLPPGLQATPELGKGSQPLSQRFNAISSEDFDQELVVKPIKVKRKKKKKKTEGGSRSTCHSSLESTPCSEFPGDSPQSLNTDLLSMTSSVLGSSVDQLSAESPDQESSFNGEVNGVPQENTDPETFNVLEVSGSMPDSLAEEDDIRTEMPHCHHAHGRELLNGAREDVGGSDVTGLGDEPCPADDGPNSTQLPFQEQDSSPGAHDGEDIQPIGPQSTFCEVPLLNSLTVPSSLSWAPSAEQWLPGTRADEGSPVEPSQEQDILTSMEASGHLSTNLWHAVTDDDTGQKEIPISERVLGSVGGQLTPVSALAASTHKPWLEQPPRDQTLTSSDEEDIYAHGLPSSSSETSVTELGPSCSQQDLSRLGAEDAGLLKPDQFAESWMGYSGPGYGILSLVVSEKYIWCLDYKGGLFCSALPGAGLRWQKFEDAVQQVAVSPSGALLWKIEQKSNRAFACGKVTIKGKRHWYEALPQAVFVALSDDTAWIIRTSGDLYLQTGLSVDRPCARAVKVDCPYPLSQITARNNVVWALTEQRALLYREGVSSFCPEGEQWKCDIVSERQALEPVCITLGDQQTLWALDIHGNLWFRTGIISKKPQGDDDHWWQVSITDYVVFDQCSLFQTIIHATHSVATAAQAPVEKVADKLRMAFWSQQLQCQPSLLGVNNSGVWISSGKNEFHVAKGSLIGTYWNHVVPRGTASATKWAFVLASAAPTKEGSFLWLCQSSKDLCSVSAQSAQSRPSTVQLPPEAEMRAYAACQDALWALDSLGQVFIRTLSKSCPTGMHWTRLDLSQLGAVKLTSLACGNQHIWACDSRGGVYFRVGTQPLNPSLMLPAWIMIEPPVQPAGVSLVSVHSSPNDQMLWVLDSRWNVHVRTGITEEMPVGTAWEHVPGLQACQLALSTRTVWARCPNGDLARRYGVTDKNPAGDYWKKIPGSVSCFTVTASDELWAVGPPGYLLQRLTKTFSHSHGTQKSSQAAMPHPEDLEDEWEVI
The following text describes a protein:
Function:
Major transporter for myo-inositol. Plays a role in the traversal of the host blood-brain barrier.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSDEKNYGISLAAPARPDLGSRTASQLEKATASHVEFATPKDPGALHDATLMAGERTEKLTKFVVGLALFASVSGFCFGFDTGVISAALVSIKDDFGHILDDTEKEWISAATSCGALVGALSSGALADRVGRKWTLAVGDVWFTLGAIIICSSFSVVQMIVGRAVLGLGVGTAAAIAPLYIAEVAPTRFRGALVTVQSIAITGGQFFSYCIGIPLTGHNGWRIQFAIGIVPAVVQAAVVHFLPESPRYDLLRGQREAALATIHRSYKGMSEDYIAVKFAALEEVVGISADFNRGHTLGQKMRLVLTEGKYRKPAITALGIGIFQQLCGFNSLMYYAATIFSYAGFDNPTSVGLIVSGTNWFFTFVAMMILDRVGKRRILLSTYPGMIAGLALASVAFWKMTGSTGHRLVEGTEYPQQWSNMMLGMMVVFIAFYATGSGNITWTVGEMFPLEMRGIGASILAGGVWAANIVISATFLTLMNAIGPTPTFALYAGICLAGLIFIYFCYPEPSGLSLEEIQIIYNYGFGVQKSREIRAEHKLKAQEMRDRANSHIGGSATASDDQLNKV
The following text describes a protein:
Function:
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPSKKKKYNARFPPARIKKIMQTDEEIGKVAAAVPVIISRALELFLESLLKKACQVTQSRNAKTMTTSHLKQCIELEQQFDFLKDLVASVPDMQGDGEDNHTDGDKGPRRGRKPGSSGRKNGGTGSKSKDKKLSGTDSEQEDESEDTDTDGEEETPQAPPQASHPPAHFQSPPTPFMPFTSPLPLPPAPPGPSAPEAEDEEDYDS
The following text describes a protein:
Function:
Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).
Subcellular Localization:
Cytoplasm. Membrane, caveola. Cytoplasm, cytosol. Note=Localizes in the caveolae in a caveolin-dependent manner.
Domain:
The leucine-zipper domain is essential for its localization in the caveolae and for its interaction with CAV1 and EPS15L1.
Sequence:
MRESALERGPVPEAPAGGPVHAVTVVTLLEKLASMLETLRERQGGLARRQGGLAGSVRRIQSGLGALSRSHDTTSNTLAQLLAKAERVSSHANAAQERAVRRAAQVQRLEANHGLLVARGKLHVLLFKEEGEVPASAFQKAPEPLGPADQSELGPEQLEAEVGESSDEEPVESRAQRLRRTGLQKVQSLRRALSGRKGPAAPPPTPVKPPRLGPGRSAEAQPEAQPALEPTLEPEPPQDTEEDPGRPGAAEEALLQMESVA