lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription.
Subcellular Localization:
Nucleus.
Sequence:
MAGVVKEFDSSHDMFKVREEPKVVFNNKDLSEEMMKIKEEPMLVFDEHEDFVGGEEAPKPIEGLRDGGPPPFLKKTFEMVDDPTTDSIISWSSSKNSFILWDPHKFSTDLLPQRFKHNNFSSFVRQLNTYRFKKIDPDRWEFANEFFQKGKKHLLRDIKRRTNQPQNTQKQEEIRKQEQQQCCGHQTNSTMETELKNLRKERITLKQEILKMKQQQENTEKHLEMVEERMLRMEFKQQQLLVFMSKAFRNPIFVKLLQHLVQKQKTGSVEMCKKRKLEQMLDTDDLDRFQEMWNMIEPDAYTVLSSDGSVSPPEDQNTSDKSGSNGSDYNSESFILWEKLMEDELIFGGEQSGKDQTETYLQEWEELIPKA
The following text describes a protein:
Function:
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
Subcellular Localization:
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MFSTAASPYDDLVIKATDENLASEDWALNMDVCDKVSSDGQNGARQAVTALQKRLSHRNPNVQIYALELANSLAQNCGKDLLGELSSRNWTSALDRLINDRATSTPVKKKALSFVKSWAKQIEETGDPNLGLMGELYDQLRAKNHVFDEPEPTPESAEEVRRRQEEEELQRVLELSKQDKGGRSLFTYQPSGSAGASSSSAANNNTSPSIPQSQAQPLAQDQAQSQAAPQVTGYAPQPQKIYSPQPLEPEPPRVDLNTATRVRAIYPFTGQEVGELDFERGDVIKVLDRGFKEWWRGACNGKIGIFPVTYVEALPEPTPKELQEKAQEEARVFASLGLVDQLLQTLKGIDPARGDKLDDHPEIEEMYQASVALQGQINTLIKKYSDQKAELEHMNANFIRAMGQYEELRNGPPLVQAQPFGYVPPQPQPLLQQQNSYSYQQYPQQPQQQPQPYAQAPYAQQAQPQLQPEQYAQQTPSPAAQSQASYTAQQQPYPAQVQQDPAAASPPPNQPFYHHGGSTTSVNRIPSAQTAVQPQPHGAPSFPPSSPPTRQVTEPGVAGLGAGDQQAWDQYYQQHGQQAPHSSQHPSQPQSQPQSQPQSQPQSQQGSYYPAHAQAQGYQAAYATVPDGRAYASPPLPGTQQGQGVEGVTAGMDRMSVHAP
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MNTLLRLKGLCGNKHKICNNVLRKCYSIKGNITKGDMEELIDDNIFYEKEEGKKGNLGNYYVIRDMKNGKIGFVYNRTAVFDSMSNIDMVYMNKLNIDNKKDIHPSNEMHYVNERMRNNLLYNENKKYNLLNNIFHFKKYKVCRRKSFNGLENMGNYKYFSSTIGFNNNNTMKDKDKGEKNIGVGSNKCGVKYNNIDNKRMDINNNIRNRLLKNNKLSGNLINNKESKTLKEIYLDKKEKEKLIKMYLLLSLLLMPFGYIYMYCIENDITVEEFIKMMKKKGDVLENKYNDILNEFIDKYFPLSNEPLLPDFKDLNYPENLPTLVIDLNYVIAKLEYDRKTGWRVLKRPYADRFFKELSSFYEIVIWSDDNFPVAQEVISKWGIPAIGCLHRDQCSKKKKSYVKDLKRLGRNLDRVVIIDHDAKAFMLQPENGILIKEFHGDLNDKEMLCLIDLLKSFAISTHDISQFLKKHGGGDYNIGKRYLQQKSDTEQKSQRIRNIGKIFHLDNKKSTNGISFNS
The following text describes a protein:
Function:
Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).
Subcellular Localization:
Cytoplasm. Cell membrane. Cytoplasm, myofibril, sarcomere, Z line.
Sequence:
MGKDYYCILGIEKGASDEDIKKAYRKQALKFHPDKNKSPQAEEKFKEVAEAYEVLSDPKKREIYDQFGEEGLKGGAGGTDGQGGTFRYTFHGDPHATFAAFFGGSNPFEIFFGRRMGGGRDSEEMEMDGDPFSAFGFSMNGYPRDRNSVGPSRLKQDPPVIHELRVSLEEIYSGCTKRMKISRKRLNADGRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTLDGRNIPMSVNDIVKPGMRRRIIGYGLPFPKNPDQRGDLLIEFEVSFPDTISSSSKEVLRKHLPAS
The following text describes a protein:
Function:
Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus, Golgi stack membrane.
Sequence:
MKMGILVFMRNLLLALCLFLVLGFLYYSAWKLHLLRWEDSQYDRLGFLLKLETKLPVELATRYANFSEGVCKPGYASALMNAIYPKFSKPAPMFLDDSFRKWAKIREYVPPFGIKGQDNLIKAILAATKEYRLKPALDSLNCRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKLEQYEKDSIFVLAGFKWQDFKWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDEVAVAGFGYDMNLPNAPLHYYETIKMAAIKESWTHNIQKEKEFLKKLVKARVINDLTNGI
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGNSKSKEPAFDPNAQSPYNVGFQELTDANENKDMEFFARVGKAEGLSKLLSSSVESGLNADPQAAGDDSVLEHRRVFGENKHAETPPKNFFFLVWEVVQDPILILLIAAATVSTVLGAAIPEERAKSAWVEGVAIWVAVIVVTLVGAGNDYSKDLQFRKLNAQKDRIEIKVVRGGQQILVPNTDLVVGDVMLLDTGDKVVADAIVIDSQGLTMDEASLTGESDPMKKNTTADPWVMSGTQVTEGSGRVLVTAVGPNSTWGKTMALVSEAGDDETPLQQKLEVLAGAIGKVGFAVAICCFIAQLIKWCVENNGFPISEINNNGPIQFFLYAITIIVVAVPEGLPLAVTISLAYSMKKMMADQNFVRVLAACETMGGATAICSDKTGTLTENRMTVVEGWFVGRHFSTAPKANELDPEVCEQLKMNCAMNAKAFIIEKDNGKMDFVGNRTECALLLFMNKELGSNYNDYRHKYDKAVVKLYGFSSAKKMASVLIQLPDKLRLYNKGAAEWVLKRCIRCHTEAGIVEMTPALRGKLLDEVTNMAKRGLRCICLSYTDYPISDPSRPENFFEEADTVDDNLTCLGIVGIKDPVRAEVPLAVRTCKRAGIVVRMVTGDNIHTAQHIARECGILYDMGPNHPEHVAMEGPVFREMLKDPDFMALRERMNDPKADGQKEALQEMKEKINHVRVLARSSPEDKLQLVRLLKEMGDVVAVTGDGTNDAPALKESDVGLAMGIAGTEVAKEAADIVILDDNFSSIVKSVKWGRSVFANIRKFLQFQLTVNLVALVTAFIGAVVGGHEPLNILQLLWVNLIMDTMGALALATEAPHPTLLLQRPNGRTEQLINAKMTKHILVQGSYQMIWMFLCLYLLPQGPPGLEQYKVHNEAYMANQDCVKYATEVLPGQPNITNANLATSVSFTCNVLTACDMPWTSSDLSCVLTGLWAPQPVPADRATALCTNPAYPRNGTDASVCDYESWAETVQGKLDDEFMDYEIDEYKRPLSLLFNIFICTQVANEINARRINDEYDIFSGLFTNWIFMAVLAITMGAQAIIINFLGMFFKVEPLDWKEWLVSLAIGSGAWPLSLITRFISRNIAACVRFESQLPPDMDDPQLRAEVAAGYDFDFAPAGTVRPDFEGAALIGNNTNGHAAAHAAISKSDVEIGNGASGKQ
The following text describes a protein:
Function:
Required for arbuscular mycorrhiza (AM) development during AM symbiosis with AM fungi (e.g. Glomeromycota intraradices).
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MIKSISVPVCAFLVNLLVLLCGQGVLVTKVEATSNVHIVYLGEKQHDDLKLITDSHHDMLANIVGSKELASELMVYSYKHGFSGFAAKLTESQAQKLSELPGVVRVIPNSLHKLQTTRSWNFLGLSSHSPTNALHNSSMGDGVIIGVFDTGIWPESKAFSDEGLGPIPSHWKGVCISGGRFNPTLHCNKKIIGARWYIDGFLAEYGKPINTSGDLEFLSARDANGHGTHTASTAAGAFVSNVSYKGLAPGIIRGGAPRARLAIYKVCWDVLGGQCSSADILKAIDEAIHDGVDVMSLSIGSSIPLFSDIDERDGIATGSFHAVARGITVVCAAANDGPSAQTVQNTAPWILTVAASTMDRAFPTPIILGNNRTFLGQATFTGKEIGFRGLFYPQASGLDPNAAGACQSLSLNATLVAGKVVLCFTSTARRSSVTSAAEVVKEAGGVGLIVAKNPSDALYPCNDNFPCIEVDFEIGTRILFYIRSTRFPQVKLRPSKTIVGRPLLAKVAYFSSRGPNSIAPAILKPDITAPGVNILAATSPLDPFEDNGYTMHSGTSMSAPHISGIVALLKALHPDWSPAAIKSALVTTAWRNHPSGYPIFAEGSSQKLANPFDIGGGIANPNGAANPGLVYDMGTPDYVHYLCAMGYNHTAISSLTGQPVVCPKNETSILDINLPSITIPNLRKSVTLTRTVTNVGALNSIYRVVIEPPFGTYISVKPDSLVFSRKTKKITFTVTVTAANQVNTGYYFGSLSWTNGVHTVASPMSVRTDILQPHVDEN
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEAKPSKMSRLFQTSSVESKDEYEEKLERSYQAVTALTAGLSDKDAYDAITKALLKDKGYEEVSLGLLVTILTEPHNAARGYRDLTLISNDGFGLVLNSLSQLVLDRYLRFTDVVKGQVVWLLREMIKNAVNNVDNLCWNLMRHAAGGDVSAKNIALIESLLDVLVEYRSWLDKFPLLIPSVVYTYLRLVEDHNAPYLANLRQKEVNFLISLIRERFNDCIGIGRDLVRLLQNVARIPEFEQLWKDILTAPRTLSPTFTGVLQLLQARTSRRYLQSRLTPDMERKLVFFTSQVRFGNHKRYQDWFQRQYLATPESQSLRCDIIRFIVGVIHPTNELLCSDIIPRWAVIGWLLTTCTSSVAVSNAKLALFYDWLFFDSEKDNIMNIEPAILVMHHSMRSHPAVSATLLDFLCRIIPNFHQPLTEKVRNGIFSSLRKILEKRVVPSLVPLFDNGKLDPELRNMVRETFKEFCAATVPESSGVNNHVNNHVLDNEPAFSDDEEEQPLTICALDDDSDEDDDDIPLSKVRLRKVQDKLDESIDGPLGEILTKLQLEKDRESRCGHMETFLQTLMGFEGDDDDNLPMIAKTLANIIQDDHKCGELKPEQMTDDELLESIKLPLFVLFQTLYNFTKQDEDGKEILNRLLAEMRNCFPTVGYFLLYFLKVQIRTENKREDQTKASALKVSVYKEYCQSCDKKIDVCLLDDLIACHISDTKLMMWIVPDLFRDFKQQTVNNAQIIRVIISAIDSRQLQTLVGKVLQGHLVMFKSENLVPLLKITLTWESIEQFFFWQLIHAHDISIDTVLPLVTQLDYEQHSEALTAITLMLKQERPNADYVKYLFSRDLSPSGDLFIFTIVKYWCDEYIDKVAELISSLLSTRYPSTSPNKRKRSGNKTLSATVPSADQVLGHLEQLRVICERHDCMAIYTLDSMQRALNIAMNNCSDGQKKQYGQLFALLEEEEEVSSATKSRSQGRGRKPVNKSAVATKRTAVREICDSSEESSEEEEIVKPKQPKKRKKVMSDSD
The following text describes a protein:
Function:
Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator.
Subcellular Localization:
Nucleus.
Domain:
In the N-terminus possesses a conserved domain OCA for bivalent binding to class II POU domain-containing transcription factors and to an octamer DNA motif.
Sequence:
MLWQKSTAPEQAPAPPRPYQGVRVKEPVKELLRRKRGHTSVGAAGPPTAVVLPHQPLATYSTVGPSCLDMEVSASTVTEEGTLCAGWLSQPAPATLQPLAPWTPYTEYVSHEAVSCPYSTDMYVQPVCPSYTVVGPSSVLTYASPPLITNVTPRSTATPAVGPQLEGPEHQAPLTYFPWPQPLSTLPTSSLQYQPPAPTLSGPQFVQLPISIPEPVLQDMDDPRRAISSLTIDKLLLEEEESNTYELNHTLSVEGF
The following text describes a protein:
Function:
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MASFSAETNSTDLLSQPWNEPPVILSMVILSLTFLLGLPGNGLVLWVAGLKMQRTVNTIWFLHLTLADLLCCLSLPFSLAHLALQGQWPYGRFLCKLIPSIIVLNMFASVFLLTAISLDRCLVVFKPIWCQNHRNVGMACSICGCIWVVAFVMCIPVFVYREIFTTDNHNRCGYKFGLSSSLDYPDFYGDPLENRSLENIVQPPGEMNDRLDPSSFQTNDHPWTVPTVFQPQTFQRPSADSLPRGSARLTSQNLYSNVFKPADVVSPKIPSGFPIEDHETSPLDNSDAFLSTHLKLFPSASSNSFYESELPQGFQDYYNLGQFTDDDQVPTPLVAITITRLVVGFLLPSVIMIACYSFIVFRMQRGRFAKSQSKTFRVAVVVVAVFLVCWTPYHIFGVLSLLTDPETPLGKTLMSWDHVCIALASANSCFNPFLYALLGKDFRKKARQSIQGILEAAFSEELTRSTHCPSNNVISERNSTTV
The following text describes a protein:
Function:
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
Sequence:
MAKLTYRGSEYTKFKKFRIKKNDEVICITGKHKGKRGKVLSIDKKRDRVIVEGLNKRKRFMRPTQENPQGGVIEVEAPIHISNVMFYDPKKKKKAGVRVGFETVKGKKVRVSRPDKKEL
The following text describes a protein:
Function:
Involved in translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MFKKDITPSPKQKLKSSIQRNLRQSLLTTYPLLTPHIDDIIPKKASLEQIKLPDRVSLYVIDGTTPLFFQADTPSQQNTIVPHLKLVHRFPQCFPTIRIDRGAIRFVLSGATLMAPGLTSKGGRLPQPHERPPREKSAAEAENDEIEVPNEGADEEGHWSRELEKGEPVVVLAEGKEEACAVGVLVAGTKEIKEKGKGPVIEEAHFLGDGLWRMALD
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Sequence:
MPKQLTLDFFVRKHPQSSGRTVIDSESAEPIPVPVKTEDEATMKSVASFADRQKPSTPQCQTQVFIAEPLIRRVRPGLEAFRAQPTASLTSASASPSPRGFSTPGASPQQGHLKASASPLHSSIPQKNLSSKRRAASTSEESHDDIRSPNQGKQAPTTGFTRQYASIRKRLDSNTVLYIRKGRFFELYEQDSIFGNVTMGLKLTRHASSMSMCGVPDYMLDKYIKLTLDSGKRAAIADEMPEMDKVEKVQKRQVIAVYSPGSVSSALLLGTQYGILYIEDRGSADSDSKYLQFYDPLRRLILVKSEPCTMGEVIALIQRLSPAEIVISSCVYELVRAQLSVYFLGPIYAYNNLYATVCSTNLLWDISLDALESCANISSAFRYYLNYLLATDKRLTPIQQGDIAEYLTNITLSGIFRLPQNSSPIATLPMLTLSSLGILPLCSADSLARFEAVDSSVFEVYNNCVTRDGSQMLKMWLMNPLYDVETIQLRQNAIKLFADSVNHKHVEAVLTSLKAVGTSLYYLVLGCRSNCHFNSFNVLEQSTLSNRLFVQLLVTIIRTCSAAEALHTLLGSNEKNVQSNEMLRHFSSSNSCWKFLETLYNKVASMFEVDTPQTMLRKDFKLSANSNEPNLQIVDALLDRIEQRYVEYLNTLAQTHRLSPSLKDYPLTALTPATSTAKVYTFSPFPDRHLVIGDSLIPLAKQSHFARIEGITQISSTKTAGRFSVLDPLPNETIAAANLATRATESQSQYNQQALCRLLGVDVTVDGATQGTRAKVKLLIQALDKVAFRRLLELESFLLRRKNSILNTLKLDLLVFLFEHEDMIREMCSIFSQVDVLCCFSKLSRIYAHVPWSYPLFQPPVHEQEHILDISKAYHPIALKLSQARLKAWVPLDCNFQNNKMLVLTGCNMSGKSTAMRLIGIAVLLAQIGAPLPCSGMVLTPYNTILAKIGNEEDIRSTFQKETADCAELLQEALRPDARSLFLLDEFGRGTDSTTGDALAEAVCRQLTQLNLRAVVSTHSPLMALKLEQDKQVRLCHMSYEITASGIQFKHTLCHGLCTRSFGSQVARLAGFPTELLEQCDKHTRGFIYSCILSTMEAVEDMLGQK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MASRGGGRGCGRGQLTFNVEAVGIGKGDALPPPTLQPSPLFPPLEFRPVPLPSGEEGEYVLALKQELRGAMRQLPYFIRPAVPKRDVERYSDKYQMSGPIDNAIDWNPDWRRLPRELKIRVRKLQKERTTIILPKRPPKTTEDKEETIQKLETLEKKEEEVTSEEDEEKEEEEEKEEEEEEEYDEEEHEEETDYIMSYFDNGEDFGGDSDDNMDEAIY
The following text describes a protein:
Function:
Lysosomal lipid chaperone which binds to a wide range of unsaturated fatty acids, including high affinity binding to oleic acid and oleoylethanolamide, to transport them into the nucleus. As part of a lysosome-to-nucleus retrograde lipid signaling pathway, translocates into the nucleus where it activates the transcription of genes promoting longevity and activation of mitochondrial beta oxidation.
Subcellular Localization:
Lysosome. Nucleus.
Sequence:
MVSMKEFIGRWKLVHSENFEEYLKEIGVGLLIRKAASLTSPTLEIKLDGDTWHFNQYSTFKNNKLAFKIREKFVEIAPDERSYNTLVTFENGKFISHQDKIKENHHSSVFTTWLENGKLLQTYQSGSVICRREFVKE
The following text describes a protein:
Function:
Required for acclimation and survival during thermal stress. Heat-specific cofactor of XRN4 required for its targeting to polysomes and subsequent rapid degradation of seedling transcriptome during the early steps of the heat stress response.
Subcellular Localization:
Cytoplasm, P-body. Cytoplasm, cytosol. Note=Translocates from cytosol to P-bodies upon heat stress.
Sequence:
MMAETEGSVADDRELITREGGIGTKSPWKTTTSPVETIDAPVMGAHSWPALADAAQQPRPKNPPAPAPAPPSKNIPTSIPIPTPAVTGQAKSKGGGKANPGHKNPSGRHSKPGPRSNQNGPPPPPYLVHAVPYHPPPFPPMVPLPHAAGPDFPYAPYPPYPVPVPPVTESGNEKQVQASPLPPVLPAPQGDPGKPWPHQRGFDPRNMPQGAGPRNFGRPPFMGPAPGFLVGPGPGFPGPVYYLPGPPPGAIRGPYPPRFAPYPVNQGPPILSPEKLDLRDRVLKQVEYYFSDENLENDHYLISLMDEEGWVPTKIIAGFKRVKAMTMDVDFIVYALGFSNSVEVQGDQIRKRDKWSDWIPASKKSTSAETIGDGDKDSPKSITSGDNFGNPSKGSSKPTVSDFSSEGAQSSRTNNYKSGNLKSSADEKRNVEDLSNDFSNTFLLDEELDLEHRSPRKSGLSMSKSIEYEDDDMAVDDQDIQKLVIVTQNSGKSDGAGIGGTEAKNIPKELASTINDGLYYFEQELKKKRSGRRKNNSHLDTKDGKIKSGEGLNTKLGENSAANDGGEEHGIITSRRKQNKGTHKHHTAHARRFFSSNIRNNGNISESPPSSSIGFFFGSTPPDSHGPRLSKLSSSPQCTLSGSSPPVGSLPKSFPPFQHPSHQLLEENGFKQEKYLKYRKRCLNERKKLGSGCSEEMNHLYRFWSYFLRDTFVLSMYDDFQKFALEDAAGNYDYGLECLFRFYSYGLEKHFDEDLYKDFEKLSLDFYHKGNLYGLEKYWAFHHYRGKEEPITKHPELEKLLKEEFRSIDDFRAKETITNQKENKSH
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSMMNRNIGFLSRTLKTSVPKRAGLLSFRAYSNEAKVNWLEEVQAEEEHAKRSSEFWKKVTYYIGGPALILASANAYYIYCKHQEHAKHVEDTDPGYSFENLRFKKYPWGDGSKTLFWNDKVNHLKKDDE
The following text describes a protein:
Function:
Involved in the mitochondrial expression of subunits 6 and 8 of the F0-F1 ATP synthase.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MGSITHNKGNQIKKKLDSFIGISNWESLSIEHDNINHQLDITLLAIIKDITNKPDYSSCTTTTTTTTITTNNNNNNNNNNVNKNEDNSNTTNNNLIKSINKEVENSSVNNNGFISMNQQKQNYHYNIPTSLKDIKSIIIKSQKLKGQLQSLKQVFKQNIIINNQEVIEQQVDAIKQQQQQQQEQQQEQEQEQQQQQDGESISLSSSTSSGITISSLSNIEYNPSIAFKLGKEFVIGNLFIDQIILFLEFLYGIALEIETNLQYWESIEPTIYYLQKSPLFWLKYYHQQLNRRIQFSNKFSELHNLKQPKPILYISNLLNKVNSFILNKQPSSQQVEQQQQQQQERDEQQQQQQQQQQQQQQHNNSHHHHHHRNENEKKKKSKRIKHPKIELLDKIQKLKSYQVVISVIIGRLTFLLDSLKINTNNNNNNNNTADNNNNNLNDNESIKRFSELMSKSSIIIFDSLLLFNELFKKNKESNDNDKKVDDDDELIKLSKDLINEIINIRNEDGDQQQQQQQQQQQQQQQQQQQQQQQQQQQQSLQLLNFKILLNNQNLINKLMEVMVKRLSGNLSIPNVFIRNWVKLSVGSVIVFFGIKYSYDNFDSFKQSAFDIRDAFIRFYHEHLEEPLLNIWNVIRYDKKSLQLADPASLQSSIDSLGRMVIDYNIDRNHLDINSTETRQHLFQLASRGDISSIMKSYESNIRSPLQNILFGDMIRLILIQIQKEKVDVDKAMVAIDKLLQANELNFQLLAAIPSAIFLALLIWQIKKLFTNQKKTLPYSQLVIFQTLRKINRTLILNNTQDQQNNNLPNFISPLLLTQINILNYSTIINNQDNNNNINNINNNNNNNNNQLIKTQFKPFEKYGTILISTNKLRSHQRFVRENTESQWFNQDVHDLESEALSNQDKIQTINRMFQTYSFLKNIK
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSGRNNNKLPTNLPQLQNLIKRDPASYREEFLQQYKHYLSVIEIFKLQPDKPNKDLSTLVMFMAQTAHCFQQYLEDFPEQLKSLLCTHHTVMDPDQRMTLCKALIMLRNKNLISPSVLLELFFELLRCQDKLLRKTLYTHIVTDIKNINAKHKNNKVNTTLQNFMYTMLRDNNAIAAKISLDVMIELYRRNIWNDAKTVNVITTACFSKVTKILVAALKFFLGKDEDEKKDSDSESEDEGPTARDLMVRYSTGKKNTKNKKKLDKAMKVLKKHKKKKRPEVFNFSAIHLVHDPQEFAEKLLKQLEASKERFEVKLMHMDLISRLVGIHELFLFNFYPFVQRFLQPHQREVTKILLYAAQATHHLVPPEISQSVLKTIANNFVTDRNSGEVMTVGINAIKEVTARCPLAMTEELLQDLAQYKTHRDKNVSMSARGLIQLFRSLNPDMLQKKFRGKPTEASKEARIHAYGELDAKDYIPGAEVLEVEQEKKEEPEEDDGWESASLSDDDEDGEWIDVHHSSDEEQQEMAEKIQAMPTEERIAKAATVSGSRLLTQEDFKKIRLAQLAKEMNNAPGKSMKRKNIEIDSDEEERSGELLSLRDIEHLHKKPKSDKETRLATVLAGRTDRKEFVRKKTKMNPHASSTNKEKKKNKNFMMMRYSQNIRSKKKRSFRDKQIALRDSLLKKRKRLMK
The following text describes a protein:
Function:
Probably functions as a FAD-dependent oxidoreductase, whose physiological substrate is unknown. Does not display amino-acid oxidase or glycerol-3-phosphate dehydrogenase activities. Is essential for growth of P.aeruginosa in the sputum of cystic fibrosis patients.
Sequence:
MPQALSTDILIVGGGIAGLWLNARLRRAGYATVLVESASLGGGQSVKSQGIIHGGAKYALHGALTGASEAIADMPRRWRACLGSDGELDLRGVRLLSEAHYLWSPGGLAGSLTSFFASKAVRSRVEQAKGEDLPPALRDKGFKGKAYRLTEIVFDVPDLIRRLAELAGDSLLAGERIEPLREGRELAGLCVDGREIRAQRVVLSAGAGNEALLRELGLEQPAMQRRPLHMVMVKAATLKPLYAHCLGAGPKPRITVTTHPTRDGQSVWYLGGDIAETDGVARDEAAQIAEARRELAKLLPWIDLGQAQWATLRVDRAEPAQSNLLRPDNAFLAEQGRLLVGWPTKLALAPDFADRVCARLEEDGIRPSEHAALPQLPRPPLAEPAWEVAFA
The following text describes a protein:
Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MSTQVCVTRLKKELLALSKNEDIKDIFIAKPSISNILEWHYVIYGPPDTPYHGGYYHGQIIFPVEYPYKPPSILMTTPSGRFVCNSRICTSMSDFHPDTWSPFWSNCTIILGLISFMTEDENGFGSIVKSKETRKQLASQSMAFNLKNPVFVKLFPELISDYKKKGTFYSSSSTPSSTPPPSSTPSSSSSSSNISKRNVPIPTTKTTPQDTNKKKEQKNNNIPYIILFIALIIILLYLFLK
The following text describes a protein:
Function:
Involved in the degradation of unsaturated organohalogen compounds. Catalyzes the NADPH-dependent reduction of the carbon-carbon double bond of 2-chloroacrylate to produce (S)-2-chloropropionate, which is probably further metabolized to (R)-lactate by (S)-2-haloacid dehalogenase. Can also use 2-bromoacrylate as substrate. Does not act on acrylate, methacrylate, 1,4-benzoquinone and 1,4-naphthoquinone.
Sequence:
MVMAAVIHKKGGPDNFVWEEVKVGSPGPGQVRLRNTAIGVNFLDTYHRAGIPHPLVVGEPPIVVGFEAAAVVEEVGPGVTDFTVGERVCTCLPPLGAYSQERLYPAEKLIKVPKDLDLDDVHLAGLMLKGMTAQYLLHQTHKVKPGDYVLIHAAAGGMGHIMVPWARHLGATVIGTVSTEEKAETARKLGCHHTINYSTQDFAEVVREITGGKGVDVVYDSIGKDTLQKSLDCLRPRGMCAAYGHASGVADPIRVVEDLGVRGSLFITRPALWHYMSNRSEIDEGSKCLFDAVKAGVLHSSVAKTFPLREAAAAHKYMGGRQTIGSIVLLPQA
The following text describes a protein:
Function:
Skin-specific kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Involved in skin-specific regulation of sterol regulatory element-binding protein (SREBP) processing and lipid biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAPSKVAAKPAGAAKDSQCAEESGPPDSPAFILALDVGTTCVRSFVLDEQCEVRGSAVDAVELLNPQPGYFEIEPESLWRKIVGVITQAVKNAQLTPPDITCLTISTQRCTFLTWDHRSGEYYHNFITWKDLRADELVDQWNASWTKSSMNWFSYALFLLTRQSRFLAGSVLQLMNGQVTPRLLFEIMNNKKLKQALMQKKARVELLDSWILHKLRTGSSRDKDVEHITDVTSSTATGLYDPFTLSWSPLISWLFGINSKILPRVVDNGYKGFGHVHPTAFGPDWANTEIPIAASLSDQTAAIWGSQCFQKNDVKVTMGTGAFLNLVTGDRCQAVISGMYPLVAWQFKKPTRQQGAVYCIEGASHDFGTVVTWAQSCELFDSPANTSDIAQSVPDTNDVFFMPAFSGLGPPVNDYRSASGFIGLTPSTTKAHMVRALLESIVFRLVQLIEAAEKETSQKLHMIRVDGGVSRNDFVCQFLADLSRLRVERADNAESSIMGATFMAGINLGIWRDVNDLKRFRKVARVFEPRPKEYETIANRMDKWSRTIARFSDWY
The following text describes a protein:
Function:
Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety in natural or engineered linear fusion proteins, irrespective of their size or the presence of an N-terminal extension to ubiquitin. Plays a role in regulation of silencing by interacting with SIR4. Also, in conjunction with BRE5, cleaves ubiquitin, leading to the subsequent mono-ubiquitination of SEC23. Required for ribophagy, a process which relocalizes ribosomal particles into the vacuole for degradation in response to starvation.
Miscellaneous:
MISCELLANEOUS: Present with 2210 molecules/cell in log phase SD medium.
Sequence:
MNMQDANKEESYSMYPKTSSPPPPTPTNMQIPIYQAPLQMYGYTQAPYLYPTQIPAYSFNMVNQNQPIYHQSGSPHHLPPQNNINGGSTTNNNNINKKKWHSNGITNNNGSSGNQGANSSGSGMSYNKSHTYHHNYSNNHIPMMASPNSGSNAGMKKQTNSSNGNGSSATSPSYSSYNSSSQYDLYKFDVTKLKNLKENSSNLIQLPLFINTTEAEFAAASVQRYELNMKALNLNSESLENSSVEKSSAHHHTKSHSIPKHNEEVKTETHGEEEDAHDKKPHASKDAHELKKKTEVKKEDAKQDRNEKVIQEPQATVLPVVDKKEPEESVEENTSKTSSPSPSPPAAKSWSAIASDAIKSRQASNKTVSGSMVTKTPISGTTAGVSSTNMAAATIGKSSSPLLSKQPQKKDKKYVPPSTKGIEPLGSIALRMCFDPDFISYVLRNKDVENKIPVHSIIPRGIINRANICFMSSVLQVLLYCKPFIDVINVLSTRNTNSRVGTSSCKLLDACLTMYKQFDKETYEKKFLENADDAEKTTESDAKKSSKSKSFQHCATADAVKPDEFYKTLSTIPKFKDLQWGHQEDAEEFLTHLLDQLHEELISAIDGLTDNEIQNMLQSINDEQLKVFFIRNLSRYGKAEFIKNASPRLKELIEKYGVINDDSTEENGWHEVSGSSKRGKKTKTAAKRTVEIVPSPISKLFGGQFRSVLDIPNNKESQSITLDPFQTIQLDISDAGVNDLETAFKKFSEYELLPFKSSSGNDVEAKKQTFIDKLPQVLLIQFKRFSFINNVNKDNAMTNYNAYNGRIEKIRKKIKYGHELIIPEESMSSITLKNNTSGIDDRRYKLTGVIYHHGVSSDGGHYTADVYHSEHNKWYRIDDVNITELEDDDVLKGGEEASDSRTAYILMYQKRN
The following text describes a protein:
Function:
Plays a role in intracellular vesicle trafficking and exocytosis. May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MPCHRELLALLAVLGWLLVLLLDLRALALLCGTAALLGGWLGPRALSRPGWRLRLERFAGSLRPAAASPEAEEQLEQEISSTIRKVVRDFVSSWYCTVSSECAFEAEVEKAMAGLAAELRRRMARVDRQALARRLLLLCGHHLQSYLQALRGRGPLWQEYRQIAGLHPALCSPAAEVSYARASVELLLRALVPRPHLETRTGHFVVVELVACNVLLPAVRKMADPDWINLLLVGAFPRKAQGEEPSPAAPVPDSLPLIVQPDVAPAVPLLSPSPGREAGAGGEDGADVPSEPPRSEGVVLRPRGLGLLFPYEGLELDSPGQDVELLAPSPAGEFLDEPLPDVPAPLEGADTSEDGMGDLEDGHTTSSDASLLLPSAYALGPCPDIQIDPVMETEEDSPKKPSVQRPCSLGKELGTPEAPPQSPSDPGQPLPLLSSSPTAPISTFSFEPLSSPDGPVVIQNLRITGTITAREHSGTGFHPYTLYTIKYETALEGEVVGSLQQMAYHTVNRRYREFLNLQTRLEEKPELRKFLKNIKGPKKLFPDLPFGNMDSDKVEARKSLLESFLKQLCAVPEIANSEEVQEFLALNTDARIAFVKKPFVVSRIDKIVVNAIVDTLKTAFPRSEPQSPTEDLSESEVDGKCQPDGKKANKSRLRFPSSKITPVLSVSEAHDRIVYSVREGSAVSGTLSLAAMESFIQKQEKVLEAVPSKAPEGEGSEEAKEKSVQEDIDGLSTSEQGVHLDTDTDSETALADLALDLLRLLLMDHWTWLGMENIQKVFHLLFGTLIQRFISTWEQGCVFWMWHADLMLSPLIVQKKSFGISWWLEVQVVNLTCTQRWVQYLQLLQESIWPGGVLPEIPKPARTEEQKKAAAEQALQSLMGILPNVVQEILGTDKCRMSWSLVLESLGHPVINRHLVFCLLDVLLEFLVLKGSSDELETATVVPPDSSGLEKAGGAAH
The following text describes a protein:
Function:
Member of the two-component regulatory system PprA/PprB involved in biofilm formation by controlling the expression of many related genes including type IVb pili major subunit flp pilin, adhesin bapA or cupE fimbriae. Functions as a transcription regulator by direct binding to promoter regions. Negatively regulates its own transcription.
Sequence:
MDKPASRHFSVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPNIGLVICDLYLGQDNGIRLIESLKEVAGNGRFFESIILTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERLESRLHERVRSQLSLSHVNQRLEYLAESLNSIYRDIHKIKYEVHGNSQPSALRSEDSQPSAPPAPVAESQVSPSNPLFGKLSPRQQAVARLVSKGLTNYQIAYELGITENTVKLYVSQVLRLMHMHNRTQLALALSPAAMQQGSGAVVH