lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.
Sequence:
MAGKTKKSEASSSSSRNSSRSSNHRGESVVVDYGKNKSSCGYCKSSARSSISHGLGTQSITINDYQDLLDRGWRRSGCFLYKPEMEKTCCPAYTIRLKAGDFVPSKEQLRVSRRMQRFLEGTLDCKRPVESVEDPNASKDTCSHTHLGVSSLAVKESSSNNNVEKDGEENIMRFLSDQVGNIVHACSESGEFPDIQFPKASVKKVSQAKRKILVEGPEDLLYSTNIAFQIAATIKRSLPDQKDGNQGRLSRNITDENGPSPKLIAEKLESFLNQLAKTSGLSVRACNGHLNFYSAAKHASAYESSQTVSVSKGSAASSESKGCSLKNSSENTQVKRRRLEIHLKRSSFDSEEYALYRRYQMMVHNDTPDHVTESSYKRFLVDTPLIFVPPTGDGTVPPCGFGSFHQQYVIDGKLVAVGVIDILPRCLSSKYLFWDPDFAFLSPGKYSALQEINWVKENQAHCSTLQYYYLGYYIHSCSKMRYKAAYSPSELLCPLRYQWVPFAIAKPLLDRKPYVVLSDFSTLQDRESLLPHVSEDVMEVQHDDIGKEDTNDFLMYDDEGMMEPEYGSSDNEQHLPSVDVEDGDVNNILIGLKGSRVKFKDLKFAFRPSERSYLEFQLRRYMRVVGEALAERMVYSLE
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLRPATPLAVLLFAAFGLLTLATISTPIIKQIPLSSFEIKDVGDLSFGVFGYCTSSGCSPIEIGYDTSAFSDKINSDFDIPRATRSTLSSILIVHPVAALITLINFVLAIVAHFHSPSHSARYLLILFIVSFVDFIVCLLCFLVDVLLFIPHLSWGSYIVVAATILVAFCGLVTCAMRRTLVNRKANRKRIAENAEMSGENYYNRQAQTAPVTQVTGPQPTVPMISGANGGGDKLPEFTTFEKKDDRSEERIPLTSVSPIERSPATLVNDSTPPNFMDGAPSRSPSTTPVGRDQYGNPLPPQDGYAMRVGPQNERLNSRGRGGMPPGGYRGRGGFPGPGRGGGPPQNGRGGYGPPGRGRGGYGPPPRGYGGPGPRGGRGPPPQGYQGGPDRRPSPGAPYGPGPGVGTYGPSQPSPYANRQQSPGPQFAAPGYGNPEQPGPQYSAYNPRRVSLPRAESPPPLPGIDDGMPGPAVELDASPANRGVGQYGIRDSDSDVAGMLAMQQARVPDPDRGNDANGHSQEGPNDVYVPPRQAWNQGFVGSTPGLAPPTARGPTRPISEAVTATVASDYYEDVDPRFAEPSAAADKRPPPISMQSPPASNSYDDIPNRARSPAESENSNFTSISQRGINPRWNSANAPMPPPVAGVYAGGGGGGNVVPRRPVNRPGAGPADGSDLFLNSNPDFQLPGRGGNMPRAAGPR
The following text describes a protein:
Function:
Required for normal Golgi function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MDNSEAVRKGGIRPGVTSGDVGRIEKRNSEPQHSIFGTEVAGGLTTERFVSSTRNFATTRKVQKLLDVTVNDNFRELVLYMNDVVPEFLEGLYFQRGDLPSGGSEKTTPLQRPQQHNSAVASVNANGVTTATTTTTTGTASSLSSHSSAALRAALEGRVVDVHQRFLQEWSTLNEVFEEVYSLVTKLHRESEVLEATLGAHAAQAEDFSGLMTTLQAELTLVHQREREIKEFQGRYHFTAEEQRILEEGSVDTTYLDVLSSVQATHRECRQMLLSRESYQSAAAVMDSTYIAIIKGTEKVARHLKTLSGRSTSGPTSSCGEAPELTNFYLRCMNFLREENKAQWASVVEEVARLRRAAVLRQYFHLLTTGSTTTASRTYHMGGGERHNSAGGGEGSSAGIRPLEAEIGNPVFFFSSLFAWLHQAIVDEDDFFSTFFTSPVLEPRQPPLSGGKGECTDALEGGRGSPCSATVANHFDEPVGEDLMLSKSSVLDSVFDVLCKHIQSVLEGVLERFLRTASNLQDADGVGSNTGEAGSPGTEDFSSKAGSSRMGPSGPIGLTGGIARLLSAAAGRPLSLVSGASKAENRYQHVMNRSQLEALVATTVSSLTSGLQTTHALLQLFTYCSTSTFTALLGRDAALTRLIADDGKMQLLRVYHTIAKHLSDHSLDSVAGVVSRSAILRRLASAEALEWKLGGTARYFVVDFLLEYKVEDERGLDGSSFHEDQMKAQERSASTQGLKPSSFSGRPASCNPYLRSGLSKHQAQAAELLRTLETMVLPVPPEVAECLRVLQATMVEAQKHAEIMESLHVSPSYGLVQEVSGGAEAASAAPPCSEQFFAVIVQHLMSFPTVLAHQPVLSSGVDEPCKLVIQLNTMNALYETLVPHTGSSASGSKLAHYTMPLLSTVMERIEDLIKELVAALSQCVARHYLGEATNEGDEMEKAICTPEAAKTIESTGGGDGEGGVAAKEFDTRTVMDKLNEFYSVVAASGRLYVPIVSSLASPPLRDRVMQGVLDITLAVYERRYEQLLNLSSEGGSDITTTLSSDLPGRTSVEDLHPDKLRILLDTTP
The following text describes a protein:
Function:
Exhibits both muramidase and DL-endopeptidase activities. The N-terminal region acts as a N-acetylmuramidase, which cleaves the bond between N-acetylmuramic acid and N-acetyl-D-glucosamine (MurNAc-GlcNAc) in peptidoglycan. The C-terminal region acts as a DL-endopeptidase that cleaves the bond between D-gamma-glutamate and meso-diaminopimelic acid. Cannot degrade purified B.anthracis peptidoglycan, which differ from those of B.subtilis. CwlT is required for ICEBs1 conjugation: the muramidase activity is essential, whereas the peptidase activity is partially dispensable for transfer of ICEBs1.
Miscellaneous:
MISCELLANEOUS: The cwlT gene is located in the region of the mobile genetic element ICEBs1, an integrative and conjugative element (ICE) found in B.subtilis; MISCELLANEOUS: Exogenous CwlT causes lysis of B.subtilis and B.anthracis, most likely by causing at least minimal degradation of the cell wall.
Subcellular Localization:
Secreted. Note=Accumulates in culture supernatant and some of it is found associated with the cell. The putative signal sequence is required for CwlT to function in conjugation, but the putative lipid attachment site is not.
Sequence:
MISKKVVLPLVFSAPFIFFFVLCIVVVMTISRENQVGDDFIGGGDGEYETVGIAPEVERFRAVFEKYARQEGVFDQVNIIMALTMQESGGRSLDIMQSSESIGLPPNSITDPERSIEVGIKHFKKVFKQAGGDVRLTLQAYNFGSGFIDYVKKNGGKYTKKLALDFSRLQAFKMGWKSYGDPSYVDHVMRYVKGSDKNVKPVKGSMDFYETVMKEALKYEGQPYAWGGSNPETGFDCSGLVQWSFAKAGITLPRTAQEQHGATKKISEKEATAGDLVFFGGTYEGKAITHVGIYVGNGRMFNSNDSGIQYSDLKSGYWRDHLVSFGRIK
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Miscellaneous:
MISCELLANEOUS: Present with 76000 molecules/cell in log phase SD medium; MISCELLANEOUS: There are 2 genes for uL6 in yeast.
Subcellular Localization:
Cytoplasm.
Sequence:
MKYIQTEQQIEIPEGVTVSIKSRIVKVVGPRGTLTKNLKHIDVTFTKVNNQLIKVAVHNGDRKHVAALRTVKSLVDNMITGVTKGYKYKMRYVYAHFPINVNIVEKDGAKFIEVRNFLGDKKIRNVPVRDGVTIEFSTNVKDEIVLSGNSVEDVSQNAADLQQICRVRNKDIRKFLDGIYVSHKGFIVEDM
The following text describes a protein:
Function:
Binds to the host phosphopolysaccharides at the onset of infection. Upon activation by calcium, the receptor binding proteins change their conformation, presenting their binding sites to the host, and a channel opens at the bottom of the baseplate for DNA ejection.
Subcellular Localization:
Virion. Note=Part of the baseplate.
Domain:
The C-terminus is involved in host receptor binding. Host-recognition domains point upwards, towards the capsid.
Sequence:
MTIKNFTFFSPNSTEFPVGSNNDGKLYMMLTGMDYRTIRRKDWSSPLNTALNVQYTNTSIIAGGRYFELLNETVALKGDSVNYIHANIDLTQTANPVSLSAETANNSNGVDINNGSGVLKVCFDIVTTSGTGVTSTKPIVQTSTLDSISVNDMTVSGSIDVPVQTLTVEAGNGLQLQLTKKNNDLVIVRFFGSVSNIQKGWNMSGTWVDRPFRPAAVQSLVGHFAGRDTSFHIDINPNGSITWWGANIDKTPIATRGNGSYFIK
The following text describes a protein:
Function:
ABC transporter involved in fatty acid import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.
Sequence:
MTAPPGARPRAASPPPNMRSRDFWGSAARLVKRLAPQRRLSIAVITLGIAGTTIGVIVPRILGHATDLLFNGVIGRGLPGGITKAQAVASARARGDNTFADLLSGMNVVPGQGVDFAAVERTLALALALYLAAALMIWAQARLLNLTVQKTMVRLRTDVEDKVHRLPLSYFDGQQRGELLSRVTNDIDNLQSSLSMTISQLVTSILTMVAVLAMMVSISGLLALITLLTVPLSLLVTRAITRRSQPLFVAHWTSTGRLNAHLEETYSGFTVVKTFGHQAAARERFHELNDDVYQAGFGAQFLSGLVQPATAFIGNLGYVAVAVAGGLQVATGQITLGSIQAFIQYIRQFNMPLSQLAGMYNALQSGVASAERVFDVLDEPEESPEPEPELPNLTGRVEFEHVNFAYLPGTPVIRDLSLVAEPGSTVAIVGPTGAGKTTLVNLLMRFYEIGSGRILIDGVDIASVSRQSLRSRIGMVLQDTWLYDGTIAENIAYGRPEATTDEIVEAARAAHVDRFVNTLPAGYQTRVSGDGGSISVGEKQLITIARAFLARPQLLILDEATSSVDTRTELLIQRAMRELRRDRTSFIIAHRLSTIRDADHILVVQTGQIVERGNHAELLARRGVYYQMTRA
The following text describes a protein:
Function:
Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA.
Subcellular Localization:
Nucleus.
Sequence:
MLARFAVRFCSTMTKTIENAASSSNSDAALHRVQDGRVGDDSRQDQQKVRVKTNRYAMLLGYQGKNYFGMQVQRGNGEDVCPTIESHILDAMLELGWITPELKQTPYDFFFQRAARTDKAVSAVRQLCSCQMPIAIDLPSHGAELINNKLPDDIKVFGFRRVTKNFHAQKNCDGRTYSYTLPTFAFAKPTELTNSSFRISESTLTQIGEVLAQYKGTHNFFNYTSGRPFNDRSCNRYIISFEVGKPFLYKDEFRKEDVEFVTCTVKGQSFMLHQIRKMIGMMIAIVREMQDPSAVQKSFLSSDRLDIPKAPGLGLLLDRLHYDKYDRQFGNKEPHLPLSNWGDEIETAIDKFKMEKIVSEIMSTEITTQSMMMWLTDLNQHNFLDPTDDGIKQADFVTGAAKKAKEAVRAASAEWENEEEVKNVMEEESEEKVVKKEEGDAVESVEKS
The following text describes a protein:
Function:
May be involved in photosynthetic membrane biogenesis.
Sequence:
MTKIRTVSDAKRKFFTHYSRPISSIYRRFVEELLVEMHLLSVNIDFTYDPIFALGIVTSFNSFMQGYQPAEQLPAIFNALCHGVDQNPDQVRQDAKNVAASAHHIGLDAWVTAAASEQASGDNLLLNTLTGIHQRHKFKYSRLFAIGLYTLLADQDPEVKDNDEKRQDYLTRLSELLDLSLDKVVKDLDLYRSNLEKVDQLLKVLEDAAEAERKKKEKQAASTTPAIEEAPVTTAESSES
The following text describes a protein:
Function:
Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein. Nucleus envelope.
Sequence:
MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTSLPAEFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNRLVTLPVSFAQLKSLKWLDLKDNPLDPALAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKREQEKKPKKETNQAPKSKSGSRPRKPPPRRHTRSWAVLKLLLLLLLCVAGGLVACRVTELRRQPLCTSVNAVYDNAVRALRGHDILQWVLQTDSQQ
The following text describes a protein:
Function:
Subunit of heteromeric glycine-gated chloride channels. Plays a role in synaptic plasticity (By similarity). Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability. Plays a role in cellular responses to ethanol.
Miscellaneous:
MISCELLANEOUS: The alpha subunit binds strychnine.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein. Synapse. Cell membrane; Multi-pass membrane protein. Cell projection.
Sequence:
MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MSGGAPLPPSQMPLQKVHEVQFEVFKEAQIKAYAKCIIEHAKSYEHGQPVRGGINDLRMGTTDFEYSCETCGLRHPECPGHFGYVELAEPIFNINVFDVVLIALKCVCKYCGALLMDTNDPSEMKKIAHLQGLNRLRMVAKLCGSVCKRSKDIQGCEGKGRQPRIGRFVGIYPGLQIKVTQEEQDYVWHAENARQVLDRVSDSDALIMGFDRRFCHPRDLILTVLPIPPPQVRPAVTFGSAKSDDELTHQIMSIVKRNIQLRKDKESGVKAAVDRSRALLQEHVATFFNNASTYYKPAKVGDTKKLKSLTERLKGKYGRLRGNLMGKRVDFSARTVITGDPNIDVDEVGVPFSVAMTLTFPERVNVINKKRLTEFVQRTTYPSANYIIRPNGNVTKLALVKDRSAVHLDVGDVVERHVIDGDVVLFNRQPTLHRMSMMGHRVRVLNYNTFRLNLSCTTPYNADFDGDEMNLHVPQSLLTKAELIEMMMVPKNFVSPNKSAPCMGIVQDSLLGSYRLTDKDTFVDKYFIQSVALWLDLWELPIPAILKPRPLWTGKQIFSLILPEVNHPASPYDKPPFPHNDKKIMIQRGQLLVGAITKGVVGAAPGSLIHVIFNERGSDEVAKFINGVQRITTYFNYCFAFSVGVQDTVADATTLKEMNNVLHKTRQSVEKIGAAANNGKLTRKAGMSLLQSFEADVNSALNKCREEAAKKALSNVRRTNSFKVMIEAGSKGSDLNICQIAVFVGQQNVAGSRIPFGFRRRTLPHFMLDDYGETSRGMATRGYVEGLQPHEFYFHTMAGREGLIDTAVKTSDTGYLQRKLVKALEDVHASYDGTVRNANQELIQLAYGEDGLDGARIEGNQAFPIPHMTNSEMADKYRYEYNDEGSFSENMGGHYMDPFVRDSLLRDPQSVLKLQEEFEQLMRDRAMSRLVIDMEDKNKLKMNLPVNVARLIQNARTTMGKRSQVSNLNPITVINRVRELQEDLVQLFPSYHKDYNGRFVNVLSQQRVERALTLFGIHLRQILGSKRVLKEYKLNDKAFEYLLKEIRTKYQQSLITPGEIIGAIAAQSCGEPATQMTLNTFHNAGISSKNVTLGVPRLLELLNVSRNQRNASVAVCLIREYQKRNKAQEAQQFIEYCTLANITTTVQIIYDPDPRNTVVAEDEEMIRWEQAVMNAEDEEPDAEQPPSPFIARLILDNDLFNDKRLNMKDVKSAIRQVDDTYMVQANMENDGQRIVRLRPRKCTGADSVPALTKAVAQLLQSVHLRGIPGIKKTLLKEGNTFRVDPEAGGIKNESSWMVDTEGTALQRIFVGVVNSEGKNIIDFSKTSSNKIPEVVTVLGIEAARRKLLSELREAYLAYGLNINYRHYTILVDTMCQRGYLMAVSRTGINRSETSGPLMRCSFEETVKVLMTAAAFGEKDPVRGVSASLVLGNQARIGTGLFDLLLDMSKLQHVVPLDKATEARTSNVYHTDASVAPGSSTLQGSHGELPPSTVHENSSLAAGASSVYPRHERAGMYGGIPIEASEVQFSSALPTVMRTALAASNTTEYHSSHHLSGASTYLASSALPSASALDTELSSYHLQSVARSTAYGYAPMAASGMPMPGATQLSVGEGGSLPYPYEASNGERFGSLGGAASSRASAPYDPTQQPSQEFSQTEEQEEP
The following text describes a protein:
Function:
Plays a role in the process of neurogenesis.
Sequence:
MWTSATISNLILYHWCSSTFGCPENTTLPLPPPLAAAPEMNKLRQSLRRKKQTYVPEASRPHQWGADEEAVRRGKCSFPVRYLGHVEVEESRGMHVCEDAVKKLKTLGKKSVKAILWVSADGLRVVDDKTKDLIVDQTIEKVSFCAPDRNFDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQKREKECGVTASFDASRTSFAREGSFRVTSASQQAEREEVMRQLQDKKKAEAAPSLCSSIATVGAPSNPVLPAQPDQSPPQCATVPSDKSEAGGQHAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRKTNFQDKSQAIEMESSMHQEYDGINDLCNQINSSFTNKPSEDPFANSNGTRTPSMLPAVSLPPQTVQGISGWAEQTGTSASTSGFQMGHRRTPSEAERWLEEVAKAAKAQQQQPPPQPMVAVPMPVPAAIQAYSVPYDAATAPVGMFITPHMQPAYVPVAGYNPAMSYPAPSVPVVGITPSQMVANVFCSATQVPSSNLASKSNPFPQSILQTSNASAQSSQLGPKPNGTANGTSWPPDPNQLRLASTAQEVDQFEAQWAALESKSQQRLANPFSNELQKTFQIEL
The following text describes a protein:
Function:
Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation.
Subcellular Localization:
Nucleus.
Sequence:
MHLHSPPLMADGSFSLSGHLLRSPGGNPSRLHSIEAILGFAKEDSVLGSFQSEVSPRNAKEVDKRSSRHCLHKMTEEIHPQQEHLEDGQTGGYGDPYSAKTSSECLSPGLSTSNSDNKLSDDEQQPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKLEVTSMKLQDSPMLSFNRSPQPSAMSALSSSLPLDSWLTPPLSNSTALQSLPGFVTTPTSLPGSYTPPPFINPASMGHALQPLGAMGPPPPYQCGANFVDKYPLEEIDPRNNSIASLRMKAKEHIQSFGKPWQTI
The following text describes a protein:
Function:
Required for the activity of the bacterial periplasmic transport system of putrescine.
Subcellular Localization:
Periplasm.
Sequence:
MKTFIKGLVLSAVVASSQVYAEQTLNVYAWGGYLPEKSLKAFEQQEGVTINYSTFENNESMYTKLKLLKGTGYDVVFASAYFIEKMGREGLLAEIDHNQIPNMKDAMPTVLGLAHDPQNKFSLPYIWGITGLYYNSSTLPNGITKWADLWDKQYEQQVMLIDDIRDVFGMALKLNGFSINTKNEEEIKKAYESLVALKKNVLLYNSDAPHVPYVSGEATLGMQWNGNAYQGQVEMPELKFVMPEEGAVLWMDNFTIPSGSKNIPLAHKFINFMYQPENQAEIVQSLGYASATKGGRALLPAELRDNPTIFPSDEDMKKGEFINDVGPETLAIYEKYWQRLRNQ
The following text describes a protein:
Function:
May be involved in spermatogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MATQGKSVDFSVLEFDNYNDYISSFATVTDHRYLGNQNTIKTIVQLGYRTTKIPYTAEEYEKRVDLALEAIRPKLAHVGLFSDLLSPTNRDPVLLEFKARELLNLNKILSTIVFTSYIHMDGSEISGYIDLDMSWRNCFREAIKHTDWRGVFQGRSRLKPMPHHLSYSNPRYNVVKYTDSDNYQVMHDHHFGLMFMHRGDHKMISVGGQFNIYSRNAKRSMVYSPKFGYVVFYDHFVRKKV
The following text describes a protein:
Function:
Probable metal transporter (By similarity). Acts downstream of PRL-1 and protects the nervous system against olfactory carbon dioxide stimulation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNTYFISFITIIIFANGINGTSVDTSNKLLLQKANDFNLSQNLSSSRTRRTIANSFRIVGIRLEDETVETKNGIPTVLVDKEQQFRVFGSGLEENTAITFTNEKNDYGGPCLKPATDLFTPIEVSSNGFSALYSVKFPSFINEFFICAKTAEKTTNHSKAATTTPLEHQGNSDFLKIKTFEPLIPVWLAIIIIVTCLGFSALFSGLNLGLMSMDRTELKILRNTGTEKEKKYASKIAPVRDQGNYLLCSILLGNVLVNSTFTILLDGLTSGLFAVIFSTLAIVLFGEITPQAVCSRHGLAIGAKTILVTKTVMAITAPLSYPVSRILDKLLGEEIGNVYNRERLKELVRVTNDVNDLDKNEVNIISGALELRKKTVADVMTHINDAFMLSLDALLDFETVSEIMNSGYSRIPVYDGDRKNIVTLLYIKDLAFVDTDDNTPLKTLCEFYQNPVHFVFEDYTLDIMFNQFKEGTIGHIAFVHRVNNEGDGDPFYETVGLVTLEDVIEELIQAEIVDETDVFVDNRTKTRRNRYKKADFSAFAERREVQTVRISPQLTLATFQYLSTAVDAFKKDVISELILRRLLNQDVFHNIKTKGKSKDDPSLYIFTQGKAVDFFVLILEGRVEVTIGKEALMFESGPFTYFGTQALVPNVVIDSPTQMGSLQSLNMDSKIRQSFVPDYSVRAISDVIYITIKRVLYLTAKKATLLEKSRKSGTFSSETFDDEVERLLHSITENEKPSCFAQNQSTRRLSNRSINSSPTNMNRSPDFVYNSVDEAIQDDTKLKNIKHADNVTTSISLVAAELEDLHSGEQDTTAASMPLLPKLDDKFESKQSKP
The following text describes a protein:
Function:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MLIYCTLFSIVILSCLIFYKRFTLSKKRAQRKQQEYFETGLSKQTVAFLHPHCNAGGGGEKVLMCMIEKLQKTQKHNIVVYSAEEVDDQQIIEKANTRFSTHITNQDLKFIPILNKQLLEPKKRFTLLLQIFGQMRYALKCVNSFQPDIFLDSTGLPFTFFIVKLLLPNVRVIAYVHYPFISTDMISQVEKKEARYNNDDEITKSEGKTKLKLWYYKFLFFFYSLCGKMTEFAYVNSTWTYNHMKQTWKSTQLIKLFPPCQVDAFMRRKQFTNQFIIISFAQFRPEKQHLLQIEIIEALVDRLPSEISQSIKLYMIGSCRNADDDLLFETIQDTINKKNLQDYISMHKNLPFQDIQKFLTSGMIGLHTMEYEHFGITLVEMLAAGLIVVAHNSAGPKLDILANDVGFLCENLEDYVLSIVRIMQLTDEDRSRYQLMGRKQAVNFSDESFKDLFNI
The following text describes a protein:
Function:
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.
Sequence:
MSDSQGNRSVHTSIISTVYNIPMRVLIRPLPSILDESKVQSLMETLQKDDDLVPPIDVLWIKGQNEGDYFYSFGGCHRYAAHQRLNKETIAGKIIQSTVSDLRTYLGTSTPDLL
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGRGKIVIRRIDNSTSRQVTFSKRRNGLMKKAKELAILCDAEVGLIIFSSTGKLYEFSNTSMRSVIERYNKTKDEHQQLHNPLTELKLWQREAEILRQQLQDLQENHRQLMGEELRGLGVKELTNLENKLEMSLRGIRTKKEQILKDEIQELTRKGSMIHQENLELYKKVNLIQQENAELYEKAYGTRDATAINGTTNYPYRFTVSREVHAPIHLQLSQPDPQNFETPARVSN
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of a cytosine in 28S rRNA.
Sequence:
MSKKPHSIKVPTQYRATAKILKAALEQQKCIKTLIFAEKHARTRSLHTVLKKFSENRVALEKAIEETGLLRDNPSFDPSLAKILVTELLFGRKELNGESKPVQTVRSYKDRLLNSIRDFGVQRKEPNPRYVRINTNLYSLAEALDYLHKSDWRRKELPADASYADFLTAIKSLAENEFMTDLHVEGVLIFPAKWSNYWVRHPLVHSKRFILQNKATCLAAELLAPPSGATVLDMCAAPGMKTVHICNVMQNKGCIYSVEQDHVRYNTLCEITKDAGCDIVKPILGDALNLTPERFPDVEYILVDPSCSGSGMQNRMTVCDEPKEDKRLQKLQGLQIKILSHAMGAFPNVKRIAYCTCSLWKEENEQVVQRCLQLNPSFKLLSCKKALRNKWHNVGDKDYPNIGKNVLYCQPDSDLTDGIFLALFEKRREGEKD
The following text describes a protein:
Function:
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MMPRRHRPAVARTYTPMRKLPNRPERGAWHRRTACSKQPSTPMEGQKPRKNSQIGQSEGRGNHRAARSKQATAESSPGCCVHCPAAAAAPARTQGRPKAEQDRPRRVRGQNWQAAPAPKWPKPPHKSPADSKHRSTPPPPRKAEPQRAAPKSRPVVQRERGVGSGTNLPRHHLHHHRPPPPPSRPLKPCPSRGRDAVSSCPHRAARGNPSGCRSPGRRPDPGGPRPDSALPAPQMAADGADSDLEEQLKDVGARLQEAPDDSDGLLKLLYDVEKYLLRVEQSPAASTFAAVRPAMDALIKNELLTHPNAEVKLAIASCISEVTRITAPEAPYDDNIMRDLFSIIVGTFQNLDDIESPSFARRISILETVAKVRSCVVMLDLELDDLILQMFNHFFTTVTSNQPEIVISSMVTTMKLVIDESEEIQTALASYLLQKARNEERETSPASFELAEKVISSCEDGKLKPIFLQLLQVQGNPLDEYSKIVTLVCEGDKVVREDNNVDPSGKDTVDDGKLSERTISDELPQESSKLEQDGTPTTAISSGATLVDNGEANQGLASPKGPASPKGSASPKRPVSPKGPVSPKGPASPKGPASPKEKPEQPEDTKDADQLKSANEGVEPVDAKPKKPSDLDSDKDLKLKPCKSVATPHSNVDVDKEAHVVSGELSADKKVVNGVADNVPKRADTTPDVVKPKRGRPPGPKSSEKKAARNNQSSDLDLKKTEEAMDSTGKLIKRSAKDDIKASTKKTGEGESSKKQQKPSLKQHKEEILSEEDTTKDMTLKEMVSPKSLTKGSGRTKGQSGENNVVKRKREQDTEETPRSRKDKGLDGSLVGARIKVWWPDDEMFYKGVVDSFDTHSKRHKVAYDDGDVEVLLLRDEKWDFISEEEGKTPDVPSEIRRGRKGRGITLLPVKEEKIETPKSDGVELPKKRGRPKGWRPNNGGTPSTTPSKSKGKTAVKDAKGTPKTAVEIKKEGKEKATGSANKTKDDLAKDSSNQKLKEVGSKSGDGSVKGRPGRKPKSAATTTPVAGSGSGSVQEKRKDKEEKEEAEASEMEQEASGKGASSTGKKRRRKA
The following text describes a protein:
Function:
Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis. Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol. Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation. Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase; [Isoform 3]: Does not have enzymatic activities toward E1 and DHT.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTAEGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFSLEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIWTLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQKMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL
The following text describes a protein:
Function:
Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs). Also identified in a modified version of SAGA named SALSA or SLIK. The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities. SPT3 is required for recruitment of TATA-binding protein (TBP) to SAGA-dependent promoters. During SAGA-mediated transcriptional inhibition, SPT3 and SPT8 prevent binding of TBP to the TATA box. Required for diploid filamentous growth and haploid invasive growth.
Miscellaneous:
MISCELLANEOUS: Present with 1710 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MMDKHKYRVEIQQMMFVSGEINDPPVETTSLIEDIVRGQVIEILLQSNKTAHLRGSRSILPEDVIFLIRHDKAKVNRLRTYLSWKDLRKNAKDQDASAGVASGTGNPGAGGEDDLKKAGGGEKDEKDGGNMMKVKKSQIKLPWELQFMFNEHPLENNDDNDDMDEDEREANIVTLKRLKMADDRTRNMTKEEYVHWSDCRQASFTFRKNKRFKDWSGISQLTEGKPHDDVIDILGFLTFEIVCSLTETALKIKQREQVLQTQKDKSQQSSQDNTNFEFASSTLHRKKRLFDGPENVINPLKPRHIEEAWRVLQTIDMRHRALTNFKGGRLSSKPIIM