lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for the establishment of the posterior-most head and the anterior-most tail segments of the embryo. Probably function as a transcriptional regulator. Could repress the transcription of the tsh gene.
Subcellular Localization:
Nucleus.
Sequence:
MTNRAQWRNESSSEGIHQPLDAMNSDEHDEVIGDVHVCGNCRGEFVVFADFVKHKQSCIKKQVVMIFNEGQERMDESSRMSEKDHDTASDRSMTPESRKSVEPNYVSEGKAQQQDEQPGRSSDQSPNPSLPPSNVSLDNLENTPYAVAQFPRESAMVPGHPDVVMIQEQLYALQQQHLHQLHMIQSIQHQINHLTAQQQRQQIQHQHLQQLQQQGQQKQEPKDSSGSQGSPGLEEKTFEAKAEPAPHSSASTATTSCIPSTPIVPIPTIHGMIHPPHILSPAGAAAASAVQQSAIEAMHAQGRLLPPMQLPPPFHLPSQKSPFEMLQQHANRHMPHNPLGIPPPLPYHESLLSAGHKPKPPNVSVFDPKFSADDPFFRHKCRFCHKVFGSDSALQIHIRSHTGERPYKCNICGNRFSTKGNLKVHFQRHQSRYPHVHMDIRHHPPTPPLMDQPLQPPSIHQIPMPTIPNDQPQYPYEVDMTPYQPSKSTSPRESEGTMADNARRYQEEEEEEEEEMKQEMKHSNNIDRSQGGDNRESPSTSQSGSISPNERRLIQSTSPSIALSSNVFPIMSASGFPMSSGYPLPYAGFPRMAFSQNGAMPFESSKSAAELDLVKPETPPSLANLAEAGMRASETSKLQQLVENIEQKITDPNQCVICHRVLSCKSSLQLHYRTHTGERPFRCKICGRSFTTKGNLKTHYAVHRSKGPIRILHDCPICEKRFSNPLVLQQHLRLHAAEGMTIPPHMEHPRPEDMNIKADGDDMEKTDDVGEDNHMDVDERNDLPTPEEGEVPDDSFPEGDKPEDGTLPSDVNSPPAEDHSSKTLASDEDKKTSQLQSRPFMPGILGLQPVSSMANGDSSMAPSPGHSVDTKSMMSEDENRNINMSMYHRHGPESITSSMAEEELDGEFRNEVNDTDMSGALDLRPKGTPQENIPPHYKDAGDLAGYYSHDDHYSEDIKPTMTSAGLLMSVPSMQLGSRRLMRPNTTCHYCGKVFACTSALNIHYRSHTKERPFRCDCCSKGFSTKGNLKQHMLTHKIRDMPMPRYDSPINNPSHSMSPVMPKPISQELPLQQTTTTINSQTPPLKRSLSVSPEEANKRSQFKHSCSVCGKQFQTNSALEIHMRTHTGEKPFRCHICSRAFTTKGNLKVHLGTHMWNGGGRRGRRIAVEPPFIVSPKEGEIFRGDLFGMHPGFAEGAFYHYPPPHLINGFAAAAAANSKANEISVIQQPSSLHLQDSPSVIMRNSLAPSAESREAAYNREAERHREMVLSRDEALNHEIALNREEALSREMAMNREEAMSREIALNREEARSREMAMNREEAMSREMTINREEALSREMATREEALNREIALNREEAFSREMALKRELAQNKEIALERSNSRTPPVAPQLSS
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MLTRFITDVSTRFNPFSAKAKAARLFLSFLPPNARSNGMNITTQLLPRNSTETPLLYVKFKDGKEMNLDVENMGIKSIVEEVDRHSRILQKQADLNDG
The following text describes a protein:
Function:
Multifunctional transcription factor in endoplasmic reticulum (ER) stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG) (By similarity). Together with ATF4, mediates ER-mediated cell death by promoting expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the unfolded protein response (UPR) in response to ER stress. Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity (By similarity). Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response. Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation.
Domain:
The N-terminal region is necessary for its proteasomal degradation, transcriptional activity and interaction with EP300/P300.
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
The following text describes a protein:
Function:
Catalyzes the reduction of superoxide to hydrogen peroxide, using electrons from NADH and NADH:rubredoxin oxidoreductase (NROR) and rubredoxin (Rd) as electron transport intermediaries between NADH and Dfx. Is a key factor in the superoxide reductase dependent part of a pathway for detoxification of reactive oxygen species (ROS) in C.acetobutylicum, an obligate anaerobic bacterium.
Miscellaneous:
MISCELLANEOUS: The SOR reaction is believed to be advantageous to anaerobic bacteria, in comparison to SOD (superoxide dismutase), because SOR produces no oxygen by reducing superoxide.
Sequence:
MNNDLSIYVSKNSGTAVLLLQGNGTDLTCGSEPMAKIVANTTDAAQEKHVPHITKNGNNIDVSVGSVEHPMTPEHFIEWIILVSGDRLEMAKLTPDMKPRAQFHNVTSGTVYAYCNLHSLWKADI
The following text describes a protein:
Function:
Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
Sequence:
MYTSGYANRSSSFPTTTHNAARTATENAAAGLVSEVVYHEDQPMMAQLLLLPLLRQLGQQSRWQLWLTPQQKLSREWVQSSGLPLTKVMQISQLAPRHTLESMIRALRTGNYSVVIGWMTEELTEEEHASLVEAAKVGNAVGFIMRPVRAHALPRRQHSGLKIHSNLYH
The following text describes a protein:
Function:
Represses the melibiose operon melREDCA in the absence of melibiose or raffinose. Binds to two binding sites at the promoter region of the operon.
Subcellular Localization:
Cytoplasm.
Sequence:
MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEELGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFITNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGIDFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQPEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTAIVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQSCGCTAKEVT
The following text describes a protein:
Function:
Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system.
Subcellular Localization:
Nucleus.
Sequence:
MSDGNPELLSTSQTYNSQGESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLAPNGLLPAYSYQAMDLPAIMVSNMLAQDGHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGLRSGIAHSSPSPPGSKSATPSPSSSTQEEESDAHFKISGEKRPSTDPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSPPDQGEAKNAQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSAASPASLARTLGSKALLPGLSTSPPPPSFPLSPSLHQQLPLPPHAQGTLLSPPLSMSPAPQPPVLPAPMALQVQLAMSPSPPGPQDFPHISDFPSGSGSRSPGPSNPSSSGDWDGSYPSGERGLGTCRLCRSSPPPTTSPKNLQEPSAR
The following text describes a protein:
Function:
Mg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol. Required for de novo lipid synthesis and formation of lipid droplets. Controls transcription of phospholipid biosynthetic genes and nuclear structure by regulating the amount of membrane present at the nuclear envelope. Involved in plasmid maintenance, in respiration and in cell proliferation.
Miscellaneous:
MISCELLANEOUS: Present with 3910 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Domain:
The N-terminal amphipathic helix (residues 1 to 18) is involved in the membrane recruitment; Contains one Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity.
Sequence:
MQYVGRALGSVSKTWSSINPATLSGAIDVIVVEHPDGRLSCSPFHVRFGKFQILKPSQKKVQVFINEKLSNMPMKLSDSGEAYFVFEMGDQVTDVPDELLVSPVMSATSSPPQSPETSILEGGTEGEGEGENENKKKEKKVLEEPDFLDINDTGDSGSKNSETTGSLSPTESSTTTPPDSVEERKLVEQRTKNFQQKLNKKLTEIHIPSKLDNNGDLLLDTEGYKPNKNMMHDTDIQLKQLLKDEFGNDSDISSFIKEDKNGNIKIVNPYEHLTDLSPPGTPPTMATSGSVLGLDAMESGSTLNSLSSSPSGSDTEDETSFSKEQSSKSEKTSKKGTAGSGETEKRYIRTIRLTNDQLKCLNLTYGENDLKFSVDHGKAIVTSKLFVWRWDVPIVISDIDGTITKSDALGHVLAMIGKDWTHLGVAKLFSEISRNGYNILYLTARSAGQADSTRSYLRSIEQNGSKLPNGPVILSPDRTMAALRREVILKKPEVFKIACLNDIRSLYFEDSDNEVDTEEKSTPFFAGFGNRITDALSYRTVGIPSSRIFTINTEGEVHMELLELAGYRSSYIHINELVDHFFPPVSLDSVDLRTNTSMVPGSPPNRTLDNFDSEITSGRKTLFRGNQEEKFTDVNFWRDPLVDIDNLSDISNDDSDNIDEDTDVSQQSNISRNRANSVKTAKVTKAPQRNVSGSTNNNEVLAASSDVENASDLVSSHSSSGSTPNKSTMSKGDIGKQIYLELGSPLASPKLRYLDDMDDEDSNYNRTKSRRASSAAATSIDKEFKKLSVSKAGAPTRIVSKINVSNDVHSLGNSDTESRREQSVNETGRNQLPHNSMDDKDLDSRVSDEFDDDEFDEDEFED
The following text describes a protein:
Function:
Mediates the export of fixed carbons from the chloroplasts into the cytosol in the form of triose phosphates. In addition, it can also bind and transport phosphoenolpyruvate, thereby increasing the photosynthetic efficiency of C4-plants.
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein. Note=Located in zones of contact between the inner and outer membrane of the chloroplast.
Sequence:
MSALGTLSGGAAGVSGLLRLRRRAAPAPAIAAPSHLPAGTVKCAAAVPDAAPIVWGRQLRPALLLPAALLPSLQPARRHTLQPPAAAAESAGEAKSVGFLEKYPALVTGFFFFMWYFLNVIFNILNKKIYNYFPYPYFVSLIHLVVGVVYCLISWSVGLPKRAPINGTLLKLLFPVALCHGIGHITSNVSFAAVAVSFAHTIKALEPFFSAAATQFILGQQVPFSLWLSLAPVVIGVSMASLTELSFNWTGFINAMISNISFTYRSIYSKKAMTDMDSTNVYAYISIIALIVCIPPALIFEGPKLMQHGFSDAIAKVGLTKFVSDLFLVGLFYHLYNQIATNTLERVAPLTHAVGNVLKRVFVIGFSIIVFGNKISTQTGIGTSIAIAGVAMYSYIKAKIEEEKRKKSA
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds to GA-rich elements (GAGA-repeats) present in regulatory sequences of genes involved in developmental processes.
Subcellular Localization:
Nucleus.
Sequence:
MSAAPLHFKPPLFLFSLLSLSLSFLLSPLSLSVSFFSSLSSLQEKRAVLPTQVMDDDGLNMRNWGYYEPSFKEHNGLQLMSHFGDHRDTKPFLSARETPIMINPHGGAAAGTTTAAAGYHHHHPLIPMPYMRDSWVHRERLLHMLPGPGNPNFVPDHSGSGSNSIHIMHPNGTLKDPGLSLEDIGGGDGDGDGDGECVGDVGGPNGPVKKRSGPLGPKGPRGKKPKKAKETANQTGQTGQTGQRSKVMKRSLDIVINGLDMDISGIPIPVCSCTGTPQQCYRWGSGGWQSACCTTTISMYPLPMSTKRRGARIAGRKMSQGAFKKVLEKLASEGYSFDNAIDLRGHWAKHGTNKFVTIR
The following text describes a protein:
Function:
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Subcellular Localization:
Chromosome, telomere. Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MEEGTDGPPFDDTAAVATNWMCDFMFASICFYFREDRTEEFQRSANVLEWLLEGSRKIDAHRKTIPIAQFLMRVSEGKNLDSQFDTDESLTPLETALMTFNQIEEEENLKNLHEEIELVLKVQAVVICMEKGKFKLSSEILDRLFQESGSNTYVRMKLAMLIEKKDPYHEFLQNFTYAQMMKKIKTYITLKMKARPPVFLLEAAAKVVEAVAKGELEIQTKEREDCETNESLENKEENSSGECEEKDVQSCSNIDHLENREEISSSEYEEVAEQQKACNRDINQNELTNTSNIQETTEKCTKRHQRRLFFIAQRTPWNPEKPCTSKRLLSNINIGKRNRENQENISDDRTEKPLSFSAPKRKQHWTWEEDELLKKGVRKFGVGNWSKIFIHYDFRNRTGVMLKDRWRTMKKLKIVESDTEP
The following text describes a protein:
Function:
Plays a role in the maturation of immature virions to infectious particles. May also participate in viral transcription.
Subcellular Localization:
Virion. Host cytoplasm. Host nucleus.
Sequence:
MDSTNVRSGMKSRKKKPKTTVIDDDDDCMTCSACQSKLVKISDITKVSLDYINTMRGNTLACAACGSSLKLLNDFAS
The following text describes a protein:
Function:
Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MLGVKGNYLLPADCAHRLVAELQGALDSCADRQRQLERSLRVSRRLLQVWEPARTPSPVPETKEEDPSPACAPSSQDLEELELLTQALEKAVRVRKGVSNAGQRDRTPTLTSKAATSGAAAASHPRAPSRGGSRVLGTRSTKGIQRATAPPKDYPEHRLRSKGDKTHVRTQDQTTGYGPDLRDQQMTPSSAHHTTELFALKEKGTLLQLPEDFRKAVSRNSCLWAQLNSARTNDSTDATRAAKTQFLHKLQMASGCSSHRPSATEVEAHARILRKACMLLRLRMQKELAIAPTDWMQEYRCLLTLEGLQTVVGQCLHRIQVLQAAVTEQLPGECLAETRTQASSVCGGEVDSACSPELLLYASTEELQTLATLKLQVALLHQQIHLEKVLMAELLPLINTQDPGGPPWLALCRAAYSLLCEGGERFLTVLRDDPAD
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MEEWDVPQMKKEVESLKYQLAFKREMSSKTIPELLKWIEEGIPKDPFLNPDLMKNNPWVEKGKCAIL
The following text describes a protein:
Function:
Essential for proper maintenance of sister-chromatid cohesion in both male and female meiosis. Mutations in ord cause premature separation of the sister chromatids in meiosis I and random segregation in both meiotic divisions. Required for chiasma maintenance in female meiosis. Mutations in ord reduce recombination in female meiosis.
Subcellular Localization:
Nucleus. Chromosome. Chromosome, centromere. Note=In male meiosis it assembles onto chromosomes in late G2 of the meiotic cell cycle. It remains at the centromeres after chromosome condensation, through the meiosis I division until the separation of sister chromatids at anaphase II.
Sequence:
MYGETTLNKNHVIKFIKLKINNCLGCDEVEINFSKADNVHIIIYSLVTDMAKDLPAVTPVAQAILLLCSLTYPDSDSLETIPQLKIGKGSVSMSFKVYPVNKEEETEPESESDLDEGPSTSKQALERMVQRAERKAKEASTRNVHSKGIYVNVERRFDMYFALDTVSYYINGGKRQSCPLPEFHAKFFVRPQHSINLLRQLHEKCSGNWLKVIQSDGDGDAFKKFKDPDSPFETFVKLFESNPIKPNDMMGKLAKTCLHVNEAVRLTEREFILEVFNQVRHIFEYITAQEYTVWFLVPCLGDKDQLRSKTLEDFDLTKVRTSIRRAGDTSNIWWDHTDHNIKDILLVAFQLDLATHVNQSVLVISHLETLAEFSTMQYVTAFFMNDFYAKKNTEPKWICHRYLERIIDVALFLGVIVIIEYPSAFTLLQEGRHLIKCFQKENADSSRTSQWEIFEDVVKENESDLEFLKEAVGKVQQNV
The following text describes a protein:
Function:
DNA binding protein which is involved in the positive regulation of both basal and inducible transcription. Mainly localizes to active promoter sites and interacts with components of various transcription and replication regulatory complexes, such as the ORC, SAGA, THO, TFIID and SWI/SNF complexes. It may therefore regulate transcription by promoting the association of these complexes to their binding sites.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Predominantly localizes to the cell nucleus. Associates with chromatin.
Sequence:
MEHEVAVSGGDSSLEEITGSSKLKPSKNTAIKCLKCDKVYIFPSDKDDCLAHLYMEHRLVIADVEDIALLEDYLQYWEKEFHTHEFEQYCTTMFLDQLPDGKYAKNEKYYLLCDILPQDYELRRRLKEKRLSEALERHQFELTDRTFSKECLFCRAIIKGLRADYLDHLFDKHFLLVGKPEKLVYVDELLDHLEENLNRLMCLYCEKIFRDRPTLKEHMRKKGHKRINPNRREYDKYFLINYNRVPTAPTPRKQHLQKRRRETASVSTVADPETGSVDFDKHFARPDSDGEHDSDWSDWAADGEPSSIKCLFCHHLGDNFTALKKHMHEVHRLDFEKATSSLNFYQRVKVVNYLRRQMCLLRCVTCDLQFDEEELLVEHMAQESHHGIGDKESWDKPEFFFPYIENDGLLCVLDDSGGDDPDVDTVRIISEDSLAQINKDAERLSLENFKLL
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MDFLSNIPVHLCTAFLIRRSVGNGFACTRRGPVTPTDISIRNSPTRGPCLLPVSTACGPSRCRRRAPAPPLRCPSGNDAALPPSSSPRACSKRILQTLILDLSPGRQRLRHDVGGLSFLRTSQLTDLPDPPPQARPVPLQGELQAVSWFQFFPCEADSNSLSEKRLKAEQKDAATHLVLSAHLQLQNEGFLSTWTNSFVGPWDPSQGAHNPDEKIKLWLFLPGRHSSVVETAHAAISRLRVVGSGIWLAPGDSEEVGVALAQALRNSLERSLRELSYVRFGDVFTRCHPLTSNVRRPQPTIEFTFAATEEAIYVHAVVSAKHIRGLCSSDMEKLLWHCSSHSIRDGIPAIVAPTGMRGRLTGCCPSDLVKQVYSSKLKGSNGIAIGMPSHMVQSSNCQLRGQRCYVEVTFDCHSDIVMGSNNKQNTNESHVHNEEPHLIAVGKVQKKHGVDHLPVLERTFIYPAEAVVIPMMHRAFARSFNKSLWLQNWVGTSLSEMWPLWNFSDSSQPELCLALGDAFISDPFNGLGVEFNGMRLQKQYNSSSNSISSSISSISRTSSESEHATAVGAGDLEADADSLTCRQSGLSSNDQFENDGPRKVSKRPRTGATDTCVQTGTVLSATIQDAFMSDYSIAEVDNSGAAGAQNTQVGSHWDWDGDDRGIGMDIQTLLSEFGGFGDFFEDDILAFGEPPGTAESQALIFPAAEFGDVTGSPCNGVMEVSEQNICHAGLASLEGFNHQTVIHTEETTETKSDIPKDTRLSSHAESGHSTGKFDYLTKAEAMMTFAPEYAPVETPNSEFSTSIFRSPYVPRSKMVESSSSSSSAYMYNAMPPPCIESSEEKSDKPTKLTLCELGHEGISSVKSSKLYTHVACGIEKKNNRSVNSDVTSNNGEGLSSICGVKSMNAALTFQKKGEHMLESAGFLMPVKTVLATDIECMMYQTAMCKVRHTLLSLRNKVSMGLRNAMSDLVQSDSSVKSDIMTVKHELRKKDSIPVRLAGDIDGGMQDGTFTTPVGVWRSVGAPKATKPTRVCENLPSMPLNNLSDEGINFHGQRQPLQDLLDAIAFLVQQSTSFVDFSLDTNDGYGAYYWLGIQEQRRREFACGPSMIHAGCGGLISTCHSLDIAGVDLIDPLSADVQASSVMSLLQSDIKVALKSAFGNLDGPLSVIDWCRGCSHFVDSGTPGDGNEPRDSSGAFSLVGEPISPPQSTGGSSSTRDRARIDESSQQRLNQETCNLEAEQQKGFSRFRPTIMVLPLPAILVGYQDDWLKTSVNSLRLWEKAPLEPYASPKPVTYYALCPDIELLTSAAVDFFQQLGTVYEICKLGSHTPHYSGGQMELPTGACMSSGLVLVDCPQQVKVSRNHVNIVSSIRDFFLSLSKSWSPKSFIRSLTKVIKDLKLASSFSVNQKECSSGPCTVVYVVCPFPEPKAILQTLVECSSALGSVVLSQDKERRSLLYSQVAKALNCTAAVDEASASNVLMLSGFSVPKLVLQIITVETLLRIYRPSSELAILKDIAFTVYNKARRIPRAVSSSDMFQNSSFSGRSQSGLMHMTSSIPGLSKDCLVPRMSGPSLSREGEIDAALRPGPWDSSWQTSRIGGLSCEQNRSADLCGLDDARFMFEPLFILAEPGTLEHGSSPIVFGSSVLESSSLKFVDDTGGIYMQSSTSGGAAEIGTASVVDGSEHDNKAPSLHCTYGWTEDWRWLVCIWTDSRGELLDSCIFPFGGISSRQDTKVLQTIFVQILQQGCQISSSCSDAGLVRPRDMIITRFGCFFELECQEWQNAIYSFGGNDIKKWPLQLRRSTPDGVTSSNNGSSLQQHDLVMIQERNLPSSPSPSLYSPHSKSSFTKSGMGQPNSKKQILVGQTGVDSSRSSLQLVQSISLVGVSIDHSLHLILQADMSSSGGTQSSSSSSVTSYVEGFSPLKSLGLMQASYLLIPSPNMRCLPPLPLHLPTCLTSESPPLAHLLHSKGSAIPLATGYIVSKTVPPMGQDLGEPTREDWPSVLSVSLIDHYGGNNSNIQERMIRGAGSSNAVKQVRNVNPESVNKDYELETHIVLESIAAELHSLSWMTVSPVYLERRTALPVHCDMLLRLRRLLHYADKELIRLPENVL
The following text describes a protein:
Function:
Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRMGGSFVVLSGVIAIVVGSVLGGCARYFISGAVARRLGETFPWGTMTINVTGAFLIGIFGALATHPGSMFASPNPWLFAVTGFLGCYTTVSSFSLQTLTLARNGEPMHALGNVAFSVGLCLAAVSCGFLLADGLGG
The following text describes a protein:
Function:
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRSIASKVLVIGVVVVLAFFVTQYVLLNTTVFNSIMERKKEEAKHLVESVYGILERAYEMEQKGELTREQAQELAKSLIGKIRYDDNNYFWINDTHPRMVFHPIKPEMNGQDLSNYKDPNGVYLFNEMVKVAKEKGEGFVSYSWPKAGSDKPEPKISYVKLFEPWGWIVGTGIYVDDVKVTVGNLIFRNVLTVSVIGIAVIIMIFFYGRVLSRKTKAVLSALEKISSGDLSVSVDIKSKDEFGLIAQKLNETVGNLRKMVQEIDKSQDEVERVSEELFALSQQLRSALEEIARASDTISKEVQNASASIEEVTSGSEEVSANSQNISKLIQEISENADNIADFARNGQRVLEEAVKKVEDVSENSRETADVVSNVTESARNIEEIVRTIQSIAEQTNLLALNAAIEAARAGEAGRGFAVVADEIRKLAEESQKATEEISQILENIREGVERTNEMSKKNVEITKDARRLVEESYESFNQIVTRIEDLAARIEGIAASAQELSAASEEMSSALDAVAKTTTTVADEVEEVSENITEQEKAAKRIADIGTELKKLSDELKEDVERFKI
The following text describes a protein:
Function:
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
DAETAPVASLTFSSYYQHSSPVAAMFIAAYALIFLLCMVGNTLVCFIVLKNRHMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSV
The following text describes a protein:
Function:
Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin. Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598. OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation.
Sequence:
MEGRYSIKTRWTPTGNAEHSENFYKVDNMAQAGIYKSQKVASGSDSYLTDLTSSPSTSHELRVPTPSNVETLRTLANIRIITQRPASATIEPIKYLPGYSTTEHYIKKDGNCLFRTFAHFKYGDQEKHIQVRQEMIKYIEANPFEFQDFVEGEDPEPEIRLKKYLYRIKNGAWGDELSIKALSEAYELDVVVVSVSDRSMYAQLHVGNKGTTGFNGAYLQNDHYELLFQA
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. A stable (half-life 27.6 minutes) endoribonuclease that in the absence of cognate antitoxin RnlB causes generalized RNA degradation. Degrades late enterobacteria phage T4 mRNAs, protecting the host against T4 reproduction. Activity is inhibited by cognate antitoxin RnlB and by enterobacteria phage T4 protein Dmd. Targets cyaA mRNA.
Subcellular Localization:
Cytoplasm. Note=May associate with ribosomes, it sediments in a P100 fraction (pellet of a 100,000 x g centrifugation).
Domain:
Composed of 3 domains, the NTD (N-terminal domain, residues 1-90), NRD (N-repeated domain, residues 91-197) and DBD (Dmd-binding domain, residues 198-357). The DBD is responsible for dimerization, growth inhibition upon overexpression and recognition of T4 antitoxin Dmd (via residues 327-357) and antitoxin RnlB and subcellular location.
Sequence:
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSLGQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGKLQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAAPDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHSLFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
The following text describes a protein:
Function:
Probable lipid hydrolase.
Sequence:
MGQRIPVTLGNIAPLSLRPFQPGRIALVCEGGGQRGIFTAGVLDEFMRAQFNPFDLYLGTSAGAQNLSAFICNQPGYARKVIMRYTTKREFFDPLRFVRGGNLIDLDWLVEATASQMPLQMDTAARLFDSGKSFYMCACRQDDYAPNYFLPTKQNWLDVIRASSAIPGFYRSGVSLEGINYLDGGISDAIPVKEAARQGAKTLVVIRTVPSQMYYTPQWFKRMERWLGDSSLQPLVNLVQHHETSYRDIQQFIEKPPGKLRIFEIYPPKPLHSIALGSRIPALREDYKLGRLCGRYFLATVGKLLTEKAPLTRHLVPVVTPESIVIPPAPVANDTLVAEVSDAPQANDPTFNNEDLA
The following text describes a protein:
Function:
Has strong antibacterial activity against P.aeruginosa.
Subcellular Localization:
Secreted.
Sequence:
MFQLGSLVVLCGLLIGNSESLLGELGSAVNNLKILNPPSEAVPQNLNLDVELLQQATSWPLAKNSILETLNTADLGNLKSFTSLNGLLLKINNLKVLDFQAKLSSNGNGIDLTVPLAGEASLVLPFIGKTVDISVSLDLINSLSIKTNAQTGLPEVTIGKCSSNTDKISISLLGRRLPIINSILDGVSTLLTSTLSTVLQNFLCPLLQYVLSTLNPSVLQGLLSNLLAGQVQLAL
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MSYYDIDSIIAENQKIPCTCLVSIPGLGHEGREVSQGSKVELPFWLAEVFAVNSFVDIHMPPPFSSVVRNALKANPNTVALRDTTTHFYHFAEQLLHVVSDTSLAEVVLDTLRQRSMEIADAAVNPQGAIQQNNSFIEGLDDFERLLFRLAYLSHRDIARWQKQN