lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Late endosome. Lysosome. Note=Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes.
Sequence:
MMVTLLGATTLVLVTLAPWVLSAAAGGKNLKAPQKVEVDVIDDNFILRWNRSEESVGNVTFSFDYQKPEMDNWIKLPGCQNMTSTKCNFSSLKLNIYDEIKLRIRAEKENTSSWCEVDSFTPFRKAQIGPPEVHLEAEDKAIVIYISPPGTEDSVMWALDRSSFTYSLVIWKNSSSVEERIENIYSRHKISKLSPETTYCLKVKAALLTSRKIGVYGPVHCIKTTVENELPPPENIEVIVQNQNYVLKWDYTYANMTFQVQWLQKPGNHLYKWKQIPDCKNVTTTQCVFPQNTFQKGIYLLRVQASDGNNTSFWSEEIKFDTEIQASLLPPVFNIRSLSDSLHISIGAPKWSENKPVIQDYPLIYEILFWENTSKAERKIIKKKTDVTIPNLKPLTVYCVKARAHSMDEKLNKSSVFSDVVCEETKSGNTSKIWLIIGIFTVLLALPFVIYAVKVLLRCINYVFFPSLKPSSNIDEYFSEQSLKNLLLSTSEEQIEKCLIIENISTIATVEETNQTDEDHKKYSSQKCWDYGCEPPCMAGLTFGKALSLWKFVSLKRRLETYSDCLPPLLIRLLQFNDPAQDFWPWVHHWENVLQTG
The following text describes a protein:
Function:
Involved in the cellular supply of leucine from externally offered leucine-containing dipeptide substrates.
Miscellaneous:
MISCELLANEOUS: Present with 2910 molecules/cell in log phase SD medium.
Subcellular Localization:
Periplasm. Cytoplasm. Mitochondrion.
Sequence:
MPIVRWLLLKSAVRGSSLIGKAHPCLRSIAAHPRYLSNVYSPPAGVSRSLRINVMWKQSKLTPPRFVKIMNRRPLFTETSHACAKCQKTSQLLNKTPNREILPDNVVPLHYDLTVEPDFKTFKFEGSVKIELKINNPAIDTVTLNTVDTDIHSAKIGDVTSSEIISEEEQQVTTFAFPKGTMSSFKGNAFLDIKFTGILNDNMAGFYRAKYEDKLTGETKYMATTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTHLSNMDVKNEYVKDGKKVTLFNTTPKMSTYLVAFIVAELKYVESKNFRIPVRVYATPGNEKHGQFAADLTAKTLAFFEKTFGIQYPLPKMDNVAVHEFSAGAMENWGLVTYRVVDLLLDKDNSTLDRIQRVAEVVQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYVTDTLQHALSLDSLRSSHPIEVPVKKADEINQIFDAISYSKGASLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTEDLWDALADASGKDVRSVMNIWTKKVGFPVISVSEDGNGKITFRQNRYLSTADVKPDEDKTIYPVFLALKTKNGVDSSVVLSERSKTIELEDPTFFKVNSEQSGIYITSYTDERWAKLGQQADLLSVEDRVGLVADVKTLSASGYTSTTNFLNLVSKWNNEKSFVVWDQIINSISSMKSTWLFEPKETQDALDNFTKQLISGMTHHLGWEFKSSDSFSTQRLKVTMFGAACAARDADVEKAALKMFTDYCSGNKEAIPALIKPIVFNTVARVGGAENYEKVYKIYLDPISNDEKLAALRSLGRFKEPKLLERTLGYLFDGTVLNQDIYIPMQGMRAHQEGVEALWNWVKKNWDELVKRLPPGLSMLGSVVTLGTSGFTSMQKIDEIKKFFATKSTKGFDQSLAQSLDTITSKAQWVNRDRDVVNKYLKENGYY
The following text describes a protein:
Function:
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MSDPLNAASLLGLLPTLLPQGTTSPLPLSTDAIAALVHAIHTALQFRLISPAPQPVDDNSKLEQPRSGGDNDDAMSEVTAVEQEDNSQPPIGRLAEGWNSRGEDSYSFQYRHDQSAMNFRVRVGKMGNRVQIDAMAEDGEPHNLSVVRSELVDSGLFPIPSSATASSASNQESPDASATAVGFKSMNDVKTFVEKYSRDVISRLLPGLSIPGYSQVSGSDPRGPPPAGAPQGSEPSPARPSVPRTGDPLLDNINNINPSGRNPASLGHRDLDPLASLRPPGSFNPNRDGGGMLMDFNHPMFDSRRGRGLGDPDLDGPGGSVQPPGSRWDPVGPSPDGVGGGGIFPGVGGNPLGGVGRGDRDRWGDEMPPPGEFGPDLGRFGGGNGIGGPLGGGRGGGRFGGGGGFGGGGGFGGNMYM
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MDVKEELEALQLGESEDVAMEDADTGVVTLDKVSLLQESVDKTALSMFNALRLLPAATGDDAKQQETKDAITTLANDVLKMVQETDALIDDLPGLDKTEAEQMEELRRLQIQSEEEAQTLRQVAEEAEPPTTASLHFTWLENGVTFEFALRDNILLTLNHLMRQFTASVILLTAIFACFSSFATAWYGTVKFYADVEFEGATYPWGISKTQRCYNLSCWDNRASSVKWEGLPTSGSFSGKSRIAFFTGKDCTGDSRDWPTDGYINDKKGNYPMDFTLDGINDGISSFIVWETSKRITSGKDTPCPWGTS
The following text describes a protein:
Function:
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MTAPTGDRPEPQHGAGMWAHAGTSPTSTTLFHFLQGKTLAASRSPHSDMVRSSCLMIAAALACASCRATRIVDATCTEITANKSYTCEGLGLREIPGSLPVTTEILDFSFNVLPSLQNSTFSGLVSLLYLDLTRCQINWVYEDAFHNNRRLQTIVLTGNLLMFLSDTAFAGPQSLRELVLTQTGISTISFIPMTNLDMLDTLILGSNHISSLQFPPNFPTKNLKHLDFQMNHIRVITAEDVSILQKTSNMTLIFKGNDILHIEPGAFQSYFYSLDFGGCADIPGVLAGIRNSTTQTLWLGTFSDVEKKTDITPGVLEGLCNISVKDLYLQLRHFENLNAATFHCLTRLRKLDLTHTHISALPPGISGMSSLRELVLSINSFQHLCNVSSASFPSLTHLHIKGNLQALQLGSGCLEGLAELRYLDLSHSHVESLDCCSKALNGLSSLQYLNLSHNTKLHIQDLFFKEGASLELLDIAFTRLHIATLQGPFRNLRRLQVLNVSSSYVNTSIQHLFQGLENLVLLDLSQNTFESGIMLEDKLFRQLSNLEVLILSSCELTAVDNQAFHSLGKLRHVDLSHNKFTALSTDAFSKLKTIYLNFAYNKIRTVPRDQLDSLPGHSVINLSYNPLECTCSNVGFITWYRQNLDKIEDPEGTTCSEPKSLAGAPLATVTLSCGISTAGIIAVVLVVLCCVAISIWAARYFKQNYQPI
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MFRKRNVKGSQQKKAALRVVEDDVECLATPPVVPAKKRKIRELDDTSRSAVRASGFGRDHVSAGTQEAVARATDDAPDRRAESSGARTAVGSNVRTRVVMDYQPDVCKDYRQTGFCGYGDSCKFLHSRDDFRAGWRLNEEWKVGQTEARDLDSIPFRCVLCRGHYRAPVRTRCGHYFCGGCFARRVRETRQCAVCGADTQGVAQSAARLRELLAAGAGAGDSPDDTPAEEEPRSPGEPAAGEERRGAESG
The following text describes a protein:
Function:
Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (By similarity). Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (By similarity).
Subcellular Localization:
Secreted. Note=Secreted into blood plasma. Produced in astrocytes and secreted into cerebral spinal fluid (CSF) (By similarity).
Sequence:
FWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNPDVVNWMCYRFTIWLDLNMFLPLGVDVPGFGKTYSVEYLDNSKAAPYDWRLEPSQQEEYYLKISLGAPWGGSDLHFEEGWYDLLAGLPAPGVEVYCLYGVGLPTPRXYIFDXGFPYXDPVQQQPVHLLPLPGTQHLNMVFSXQTLEXINAILLG
The following text describes a protein:
Function:
Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits. Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. May function as a ribosomal silencing factor.
Subcellular Localization:
Mitochondrion.
Sequence:
MAAMCCKTGSFLGIMSFKRFLSRSSVISSRMCNRVCTSAVCRYHRTENWPTICSKSDAKLSRNLCHRWSSPQLDLDERRLGLQNTGLLYVGWSPYRSINHRLFTSYGSDRTGGSSYEAEAVTGRPREREARLKGVFTIDELVEELRGENAKDICVIKVPVSLQYVDFLVIVSGSSTRHLKSIAQYVISLHKDRKGARDKFVTVEGADCDDWMAIDLGNIALHMMLPETREKYELEKLWTLGSEYDDQTRDISFLNFPFALSDQFEILQTEE
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MSNTEHNVESKNVTDTLDEILRLQEDIQARIGSSNHNLETNFESIKDFVSRAHAYIPILNQISKDMIEICERTQALKKKTSQLELSDTNIEDGSTTSTPTTTNKSQ
The following text describes a protein:
Function:
Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
Subcellular Localization:
Secreted.
Sequence:
MADAKTSWLGAALSLTPLFFLICCVDAASFQHYQLLQKDPDYRFKNLQRFPSPDMIKALEYLESLRQQANKGESIPDYNSFQGIQVPFQQKEIKDQSHLADSLKDSLSEDESQWMQIILEALRQAEKESKAASKENKAYPLSSDKSFPIEVSDDYESQQWPERRHRHTKLPRLYEESTRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKLTEPSNRKRERLDEEQKLYADDEDDIYRVNNIAYEDVVGGEDWNPIEEKVESQTQEEVRDSKEEIEKNEEEVDDEMKRSGKSGLLDEDIRKENKDQLSDEVSRLMNYYLKKIMNGAGNGRQRSGQNEEKRATKVLEKRLDPQAIYELIEISRNLQIPPEDLIDMLKVGEKPRERMETEQDSELPDDTDETSEADFDHPEVFQSKTNSKNGYPKPPANAGPDALPESLNIEDILNILGTDNVANQNPAFFGKQLSRENVLPRLTYMPGRPRGHQAPKAPWLTDQERRPMEYENVNGKDEELGDYLAKMLAKYPEVMNSNQMKRVPVSVSSEDEQQEEDQIEQAIKDHLSQLGSQESEKLALANKRLSLVQENDDTQNGQYLDEDMLMKVLEYLNQEKSEKGRGHMNKRAMENM
The following text describes a protein:
Function:
Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Microsome membrane.
Sequence:
MQPPPRTAPPGAVGPPPTGGVPNAFRRTKTYKPGNAPVSGAAAPIPPVTNPFAYGRQTPQTMALENHPAPMKSSPLPMQNQPPSGFYQMAPVQNQPLPSQTMESAQGSQSVPTLPSLSGPPGVNVFTPNRKDHGPFNSREHSPYHAQGAPDNSFEGPSFAAAPLQNRPPYVPSAMPFPPQNMQPLATQWMSDHGSRPPSVHNYFQPSSDHSSPSVSAPLPDLSTANIPQQIPPQSHVYSDQLGQSSQHNATLFPSSATSTTQQLLEKAESNKPPAPEHYNPQLPTQGYFSQNFGSPDPWFNPPPGEHFYHQMGGIVTNNLPNPANTEQAPIPVQSGELPAGNPVSYESDPGTLSMFFKGNDVENEEMLVSKGKTANGISNADSFVPSQDAFFNPGFPNTQLQSSQLQTGTDITQSSYLNDSGFARDSQKNIGTHFDNVENLECVPNQEVLPNEPPNIPEMPHNLGDNFEGGPNLETPDSIPHPVRSESVSSSYSNISHSSASSSRRPQGVVGTFIQQEIAKPTEETSAGYFEQIDTSPAGDVIDQNKMYHTQLSQPPTPSPPKPTGIFQASANSSFEPVRSHGVGVKPIEIDQARMVMEKSNGAQNNAPQGVVISDASPGNLEQPPDNLENIFIPSPRTPSVVQSHERRPSSRAHGTRVKCESPATTLWAQNEMPELGANILLAPAAPPVHGLFKQPSTEVIQPPEDGPLEHSFQQLQLSSDQASPSQKPETSSENLENPPKVTKDAQQTGKAQHEQQQLSTAAVPPMPTNTQQPADDTSQKPEAQPGLLRKEAALPAQPSQCPAPNNEYPQPQYAPGLGGPQPPSMYPPQPLPPNTSQQPPPDLQRPPSSHTPQPGYGPPSQPPQPPYGPYYGGAYPEYPDGRPYPPYPPPADPRAHQPYYQEDPYRRYDPRYGRYDNYNPAYREGERYQYPEQPERPSSRASQYSDRPSSRQGYAEDYYLKASRSAYDEYYADFYKKQYDYGASYDSRYRDYYDQSYWYNYDSEAYRRRDPYYSQAYLQRPEGYDDRWRYDPRYDASFDDEYVRPRDAYGDEYDRRSVHSEQSAHSVRSSRSQRSSFSSRSQQSQVYRSQQDLVGGSYDQAGQPTSLQADYSYRQYPDAVDGSQGYPDYQYSAGYQVESGWPAVEQAPPRPVTPEKYTVPHMCARFGPGGLLIKILPNLPSEGQPALVEMHSMETVLQDSQEQEELRSFPGPLVKEETHKVDVIKFAQNKAMECLRNESLLDKDSAFLIWEFIVLLCRQNGTVVGTDIADLLLREHKSVWLPGKSPNEANLIDFNNEPLEHAEEELGSGQLSLLSDTFMTVPENAGKETERFRELLLFGRKKDALESAMKNGLWGHALLLASKMDNRTHARVMTRFANSLPINDPLQTVYQLMSGRMPAAATCCGDEKWGDWRPHLAMVLSNLTHTLDLDTRTIATMGDTLASKGLIDAAHFCYIMAQVGLGVYTKKSTKMVLIGANHSLPFFRFASNEAIQRTEAYEYAQSLGSQPCYLPNFQVFKFIYACRLAEVGLSAQAFHYCEVISRTVLSHPSYYSPMFVSQLIQMSAKMRFFDPQLKEKPEQELFIEPDWLIQLRQLDGQIKDGAIMYSLDRATPQQYASSTPSSEFDQPSPPDGLGMSQDVNGAAPEIPPTTSFMPNPGSQVQLVPPAPPTILDGTMPSIMPPPAEGGVQFYPVPPVPLCPVPGPVPPSQGPGFPPPTPGYGVPNQQEQHEMYPGQHMPLQMPPSETLPTVPERQQNHQPGNIHLYTGTRYHGNYIDRSLVPPGGSHSSLPPQVLQPPLKKIDIHLNSQPSSPSRSTFTQGPMDFYDHMAIMGPGRRSRSTSQSSMHMGYGRRSRTTSESSSNSVGRDRSNSAAKQPSPPPPSIPEQPVSKSEDSKTATKKDSPKKGGGAGGWLNWLYRKRNEAYLPDDKNKSIVWDENKKRWVNLDEPEEESKPPPPPPTSFPKLTPQQRPGATAGPPSGAPPVNIFSRKAGTRSRYVDVLNPGGPKPSPIPADLFAPLAPMPIPTNLFIPSSASADSQQPTEGSVPETEQNTGQTISDTSSQPQFYNPGLYTPSTEGTSNTDATQAGEAPNQPHVQEGPIAGGVAFYNPSQFAQPTAPSGGARTGKFGQRKYPVLK
The following text describes a protein:
Function:
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
Subcellular Localization:
Nucleus outer membrane; Single-pass type IV membrane protein. Rough endoplasmic reticulum.
Sequence:
MTQQPQEDFDRSVEDAQAWMKAVQEQLQVNDNTKGPRAALEARLRETEKICQLEPEGCIKVELVLRAAEALLATCQEGQKPEILARLRDIKSQWEETVTYMTHCHSRIEWVWLHWSEYLLAQDEFYRWFQKMVVTLEPPVELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAGSLFSRIGDPSVDEEAQKRMKAEYDAVKARAQHRVELLAQVAQDHEQYREDVSEFQLWLKALVEKVHGCLGRNCKLATEPRLSVLQDIAKDFPRGEESLNRLEEQAVGVIRNTSPLGAERISGELEEMRMVLEKLRVLWKEEEGRLQGLLQSKGACEQQIQQLEVELGELKKVLQRLAQQGLEPTVKTATEDELVAHWRLFSGTRAALASEEPRVDRLQTQLKELVIFPDLQSLSDSVVAAIQEYQSMKGKNARLHNATRTELWQRSQRSLNDLQLWKALAQRLLDITTSLPDLASIHTFLPQIEAALTESSRLKEQLSMLQLKTDLLGSIFGQERAATLLEQVTGSVRDRDLLHNSLLQRKSKLQSLLVQHKDFGVAFDPLHRKLLDLQARIQAEKGLQRDLPGKQVQLLRLQGLQEEGLDLGTQIEAVRSLAQGNSKYQHKVDQISSDQQALQRSLEDLVDRCQQNVREHCTFSHRLLELQLWITMATQTLESHQGDMRLWDAESQEAGLERLLSEIPEKEVQLSLLQALGQLVMKKSSPEGAAVVQEELRKLMESWQALRLLEESMLSLMRNEQLQRTEVDTGKKQVFTNNIPKAGFLINPQDPIPRRRHGVNPPEEHDLHEDHPQLLREFEQWLQAENSKLLRITTMRTATAKDLRTRELKLQELEARIPEGQILFENLLRHRPARDPSNELEDLRYRWMLYKSKLKGSGDLLTESSPGELTAFQKSRQQKRWRSPCSLLQKACRVALPLQLLLLLFLLLLFLLPAGEEERSCALANNFARSFALMLRYNGPPPT
The following text describes a protein:
Function:
Component of the NF-Y/HAP transcription factor complex. The NF-Y complex stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNQINYLTSERNFLPPTDRDILNLGNNSSNSNNNSSSSNNNNNNNNNNNNNNNNNNNNSNSNSNSNNNNNNNSNNNNSSSSPDHMSLHSNGMDIHHNQQNHHYQNIQHQPHHFQQNYDERRIDYGNNNNNNNTNSMNNSNNNSNNNSNNNSNNNNNNNNNNNNNNNNNNSNNNNNSNNNNFNYNIKQQPQQTLQNQIVNMNGNIITSNGNHHYPTPHMLYARMAEIVEEPLYVNAKQYNRILKRRAARAKLESENKLPKTRKAYQHESRHQHAIRRQRGCGGRFLTKADQAKLDAQNAANAAAAAANPNASSTSTTTSNITNNNNNNNNNNNTNNNNNNNNTNVNGSGGSGGSNKIASSDDDIENDVENDSDSANIKNNSNSPNQSSSSPPPSKSKVVKKSNTINKRNNNINNNNNNNNNNNNEKTQPISSSSSSSSPLLNNGHIQAQQNQSPSSSPSQNLPPLNFSNNINNNINNNGNPTNFNNNNPNNNPNNNNNNNPNNNSFLPPLSNFSNNRS
The following text describes a protein:
Function:
Specialized component of the nuclear membrane that may be involved in the connection of the spindle pole body (SPB) to the nuclear envelope. Recruits CDC5 to spindle pole bodies in metaphase.
Miscellaneous:
MISCELLANEOUS: Present with 3420 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Localization is controlled by phosphylation.
Domain:
The PxxPxF motif called the CLB3-docking motif mediates CLB3-specific phosphorylation; The CDC5-binding motif contains phosphorylated Ser-170 and is essential for tha recruitment of CDC5 to SPBs in metaphase; The CDC14-binding motif is required for dephosphorylation in early anaphase.
Sequence:
MGIQEKTLGIRKERKLVVVPRERNHVRHASQRTRSKNYKNISKKRAQQHAFGFNIAKTLAKIQAFVWGSPADEEEESVVPLSKNSQDCVPLQWQAKFAQLRQQLHSTQKELQFVKEKCHLLQSVLDDANIDQRYLESRRDMKNIERDNLKPTENLPPSPVRAVNPLVTSSPIHMSPLQSRQRPVSSLQPPKGPNFYAKYPKLPQTNILRESPTEDSVPHAE
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Subcellular Localization:
Cytoplasm.
Sequence:
MVYIASWDEFVERSVQLFRADPHSSRYAMKYRHCDGKLVLKVTDNREVC
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
Sequence:
MEINYEKVGLKVGLEIHQQLNTKRKLFCHCPTILRDDEPDGEIVRVLRPSLSEMGEVDRAALIEARKGKKFIYQFYNDTTCLVELDEEPPHPPSEEALRIALEVALLMNMNVVDVAYTMRKIVIDGSNTSGFQRTIFLARDGYIETSEGKVGITSLCLEEDAARKIEDRGDAVVYNLDRLGIPLVEISTAPDIKTPKMAKEAARRIGEILRATGKVKRGLGTIRQDINISIKDGARIEVKGVQDLDLIEKVVENEVIRQLNLLKIRDELRERNAEVVEKIFDVTEIFKDCKSKIIQNALKKKNGKVKAVLLKGFAGLVGKEIQPGRRLGTEFSDRAKVIAGVGGLFHTDELPKYGITEEEVKKLKEFVNAEENDAVIIVADEESKVDRALEAVIERAKEALIGVPEETRRALEDGNTAYLRPLPGAARMYPETDIPPIIIKKEFIEEIRANLPELPEEKFERFKKEYKLNDELAKKMVLSYYVDLFEDLCKKFKNVKPVLIATTLEGTLKEIKREGYDIDKLEDRHLEETFKALSEGKIAKEGIVEVLKGFCEFPDKSIDEILEIKGLKGLSKEEVEKIIEGIIKEHLNVVKEKGEKAYGFLMGRCMAKLRGKADGKLVNDILRKKLKEI
The following text describes a protein:
Function:
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, growth cone.
Sequence:
APKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIVANLKVKDATQITQGPRSAIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLPPAGFATEGWFIGFVSAIILLFLVLLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESDNEEKAFGSSQPSLNGDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINPAVALE
The following text describes a protein:
Function:
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
Sequence:
MQSSFLNFTSFKKAANRLLSRMESSSASCVVVQLGQGGNQLYTSFFTALANLSNPTMQNSGFFREGTKGGRVARAVLIDMEPKVEACDMFGGFLTAQSMAGGTGSGLGAYVTELLKDEYPSKCVLSHCIWPYESGEVIVQNYNALLTLAKLQESADGIIISQNDALSSICRKTLGIPRSSFDHMNDVVANSLASIFLPASWRTVCPSERNEHPRKTFRDKGQYEDEDGIKGGIYGAGMPVRLLSDLVSKLCAHPGYRMLSLRFTPQISNKSLNFTTFNWGAQIKQLQQMLMTEALGDFDLDLILPSAKKDTLLGSKVSRFGNTPNVNRCLANMLVLRGSGSLTADVSRFEHESLYPVWSVDHLSVAVNPAKLGKYEMSAGLLCNCQSTVMCTFRALSRAYGMFASRAYLHQYFKFGMEISTFEEAFTTVEDIISRYLAL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MTAVIHELLSSVMGVLVESVVSELSKHLSDLTTVLSEEWKRSKGKAMNKNKLKQANQAKSKEFAAFMELLSKATVETMVKLIHDRISAQVLEVTAKSQLSQEDKLDEGQAATSEPENGVLLEPELNKEYEMGSEHHENSGQAANNQYQQLSSAPTDILAGALVLSESQPSTSTNGATEGRQEPFVCKSCGVSFSDGALLNIHNALHKERPFNCLICGNTFKMMKCLMKHQRFHTTSDMSIEFEGPLHEEEFIVQLETCDSTSLETLEVTTQDILQNNLDGEDVSCAILESSQYAAESLVQTLNITIENTDDRQPNATPDMDMIKQSNDGLFRCKTCGKCFELRWKFINHVRAHVKHYKCSHCDKRFTMRSCLIRHAATHTGAQLFKCDICSKSFVFQASLEKHKHLHTAEKTVTCPNCQKVFPGTRSFGRHRCRAVETLYNCPVCDKQFKIKQNMLDHQTLHTGEKPYCCEICGEFYSCERYLKNHQKSHIEKTYEFSCEICEKRFSARKHLQAHMLVHTREKRYTCDVCDKKFATSGNLNRHKAGHTGVKLYGCPICLKRYTTAYALKMHTHKHTSSKPFLCDVCGKGFTSSDYMKRHKRIIHAGRRDCVCSICNKAFIFPSSLNQHMLVHTGEKHHERLISPLLKKFACDHCQKKFYSQAALTVHQRVHTKEKPYSCEICGKRFGYSSSIQMHMRIHTGERPFGCDVCGKTFNQAVHLRTHQRVHTGLKSFSCESCGKKFVDHRNLKQHKCKYTM
The following text describes a protein:
Function:
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MATTESIGAVSSDGLRNRLNPTVRLDDSPRSDSTVLAGATSDQDPHDSKDNLSSHQHTKVLGRTPDGTVFTVPHTPDMLSSIFDPRQPKTPLDIVTVVSLSLQILLYFALSRRAAQIFFLLYFSFWRASYNAGLGWILKQQSEKGWIIRHVKQHGWMDANRRPRVHNWIKQQLVTKMDVDYVFDAMPLDYNVWLMFRSIVDVILLNDFFAYSLFAFSCTRLPEGHSVVMHILRWMAGWTFDLFTSGSDRRSRVVKTTLGMGDCFFLCMYSIGYAGYYGLSLVSGSYAVLFVSLAAHFSQFLFMTFFEGPHIERTYGERKPIAARVPLRQAPFNAASRKAAHARQDADTAPQTYSDDSVKIEERTSAKRTQQPHSTQITHDMELETPTPSQTQGSTAMTTEDEASDEGHSRAFKRDALRASSSSNDAIKQHLLDKQQRPVTTLHDLHHRIFRKDTVVFRNLDLMRANDFLLVISSIYALFPLLLPALSQTPRITLLFINALAWRTFHSFGLGFALSRQSESKWIVRHFLKHYHYAQPQDAVFEAFTHWKVVYNTSLVMTYISFGALAWNCYAPIGHSDWTVGPELLRHTLGLLLVALHVWTANSSYEVLGPFGWLYGDFFVDEYPHQLYYTGIYRFLNNPERSMGGAAFFGLALVSGSKLTLLMAIVSYIAHWGFLSYVEGPHMRKLYGEAALRKDSGLTKQLKSQWVAAKDSDLFRLAQEHPTIRNFQGTIEKVQRDASEAFEEFFRQSRPRFEGMLEETKVLLQQSKDRLLIVRVQDDQKLRSEGIDKSKYSLKVIRAQSTDDSTTPRFHLGEPIAVEWKAAPNHSRRDWIGLYLLSRFGGKQGADEAGLVTKISSQGKWLGVAEEEWVGDVHQGSAHVSGDVTAEGVSVFRDSKLPWVPGLYEFRYHHDAKHNVFARSDPIEIYVGSLPADASTAKSADVIDKTADIIRTIVRYSAATTRPLRLSISQPATQRVLSSVSSSSIPEDALDDSSMEASAPLVNPLNSIDAADQDDFAIWDREQATRISTAIKCAFNIELSPEVIIAEANVKRLARDVVEGTRVLQPAFAPLMG
The following text describes a protein:
Function:
Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia.
Sequence:
MENYQKMEKIGEGTYGVVYKAKDLTAKDGRIVALKKIRLEAEDEGVPSTAIREISLLKEMNDPNIVRLLNIVHADGHKLYLVFEFLDCDLKKYMEALPVSQGGRGKALPEGTGLYGKPLNMDETMVKKFMMQLCQGVRYCHAHRVLHRDLKPQNLLIDKDFNLKLADFGLARAFGVPLRTYTHEVVTLWYRSPEILLGGRQYSTGVDMWSVGCIFAEMCTRKPLFPGDSEIDEIFKIFRILGTPNEQDWPGVTSFPDFKPSFPKWNRTDIAAIVTSLDDVGLDLLDNLLVYDPAGRISAKQTVLHQYFTGTGANGYSNGYH
The following text describes a protein:
Function:
Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MLCPQLENAGGDLQDGRHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKNVREDGVFNINVDNTCSLFRGLQKEEIVLLTHGDSVDKVAEGFKVVAQSGNIVAGIANESKKLYGVQFHPEVGLTENGKAILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALDQDQVIAVHIDNGFMRKRESQSVEEALRKLGIQVKVVNAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLRPEEVFLAQGTLRPDLIESASLVASGKAEVIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYVCKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKEDPDWESLMFLARLIPRMCHNINRVVYVFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHSILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIAATPGNEIPVEAVLKMVTEIKKIPGISRVMYDLTSKPPGTTEWE