lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Toxic component of a toxin-antitoxin (TA) system. An RNase.
Sequence:
MKRPVPEVIYLDTSALIALFNRNDKNHERAVSYLREALESGNLFLLSRPVLMEYLNGLSKRYGKEIAKENYDALTSSSFVYIENETEADWRKAWEFFFKYRDQRGIDLFDSLSFAIMERLGLKTAFTFDSDFEVHGFRTVP
The following text describes a protein:
Function:
May play a role in response to oxidative stress and polyamine biosynthesis.
Subcellular Localization:
Cytoplasm, cytosol. Note=In the cytosol of the cotyledon cells rather than in vacuoles or protein bodies.
Sequence:
MTKTGYINAAFRSSQNNEAYLFINDKYVLLDYAPGTSNDKVLYGPTPVRDGFKSLNQTVFGSYGVDCSFDTDNDEAFIFYEKFCALIDYAPHSNKDKIILGPKKIADMFPFFEGTVFENGIDAAYRSTRGKEVYLFKGDQYARIDYETNSMVNKEIKSIRNGFPCFRNTIFESGTDAAFASHKTNEVYFFKGDYYARVTVTPGATDDQIMDGVRKTLDYWPSLRGIIPLEN
The following text describes a protein:
Function:
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
Sequence:
MITDRQLSILNAIVEDYVDFGQPVGSKTLIERHNLNVSPATIRNEMKQLEDLNYIEKTHSSSGRSPSQLGFRYYVNRLLEQTSHQKTNKLRRLNQLLVENQYDVSSALTYFADELSNISQYTTLVVHPNHKQDIINNVHLIRANPNLVIMVIVFSSGHVEHVHLASDIPFNNDKLNTISNFVTNKLTEFNQNLQDDIVSFVQSEQEEIFINKLLNTMNNHISNQSNSIYMGGKVKLIDALNESNVSSIQPILQYIESNRIAELLQDISSPNINVKIGNEIDDSLSDISIVTSQYHFDETLKGQIAVIGPTAMHYQNVIQLLNRIW
The following text describes a protein:
Function:
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPKRKSPENAEGKDGAKLTKQEPTRRSARLSAKPVPPKPEPKPRKTSAKKEPGTKINRAAKGKKEEKQEAGKEGTAPSANGDTKAEEVLSTNASH
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Component of the NuA3 histone acetyltransferase complex. The NuA3 HAT complex has 2 functionally distinct forms. NuA3a binds H3K4me3, through the PHD finger of YNG1, and acetylates H3K14 at the promoter region of actively transcribed genes to promote transcription initiation. NuA3b binds H3K36me3 at the coding regions of actively transcribed genes, through the PWWP domain of PDP3, and coordinates transcription elongation.
Miscellaneous:
MISCELLANEOUS: Present with 504 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTDELKSYEALKAELKKSLQDRREQEDTFDNLQQEIYDKETEYFSHNSNNNHSGHGGAHGSKSHYSGNIIKGFDTFSKSHHSHADSAFNNNDRIFSLSSATYVKQQHGQSQND
The following text describes a protein:
Function:
Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MVKGRSEMDGVEVPEAMIDTLNRTLESLQQLETQLPQFLSLSDPDFLAELPLVERAHSLFSLAKLTSTLFSLKLRCRGVNPNGHPVKSELDKINVLQKKLERLPRFTEAQEQDTRNISEEEEPEMNYQERTSQKRKYPSSEEQFVQIDAVGSLVKVKEEHVGDNNGNIKEAIVIDISDDDE
The following text describes a protein:
Function:
Involved in a dynamic process of vesicle-mediated thylakoid membrane biogenesis. Required for the normal organization of vesicles into mature thylakoid stacks and ultimately for leaf development (By similarity).
Subcellular Localization:
Plastid, chloroplast outer membrane; Single-pass membrane protein. Plastid, chloroplast stroma.
Sequence:
MAAISSLPFAALRRAADCRPSTAAAAAGAGAGAVVLSVRPRRGSRSVVRCVATAGDVPPTVAETKMNFLKSYKRPILSIYSTVLQELLVQQHLMRYKTTYQYDAVFALGFVTVYDQLMEGYPSNEDRDAIFKAYITALNEDPEQYRADAQKMEEWARSQNGNSLVEFSSKDGEIEAILKDISERAQGKGSFSYSRFFAVGLFRLLELANATEPTILDKLCAALNINKRSVDRDLDVYRNILSKLVQAKELLKEYVEREKKKREERSETPKSNEAVTKFDGSLNSMRH
The following text describes a protein:
Function:
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation (By similarity). Involved in phase separation into sub-nucleolar condensates.
Subcellular Localization:
Nucleus, nucleolus. Note=Localizes to a sub-nucleolar compartment, the outer granular component (GC).
Domain:
Arginine-glycine RGG-box region plays a role in sub-nucleolar compartmentalization. Dispensable for nucleolar accumulation.
Sequence:
MGFDSPRGRGGGGFRGGRGGGSGFTPRGGGGGFRGGDRGRSPGGFRGGDRGRSSSGFRGGDRGRSPGGFRGDREGGFSPRGRGGGFRGGDRGGFRGGDRGGSPWRGGDRGNFRGGDRGGSPWRGGDRGVANRGRGDFSGGSRGGNKFSPRGGGRGGFTPRGRGGNDFSPRGGRGNFQSRGGGSRVGFSDKRKQYDSDGDDDEEEEVPKKKLATGTPFAKQTKPVEDDSGEDEEDEEESDEEPQPPKKTAKSAIATAAEDSDDDEEDDDEEEEESDDDAPQVKKSVAVEEDEEDEEDEEEIEMDEEDEEEEEDEEETEPVAKTPAVKSSLKSVDSTKGKQVNLSKVATPTTVDKKAPATPHPAKTSKNAAGDVPKLNFDDDSDEEDEEDEEVEEEDEEEEEEEEDVPAKKAPVLKQSLSQIAQAIEEDSDDEDEDEEEEEDEEDEEEEEDTTNVPLIKSKADLLKQIAANRAAASAAQDSDEDEDEEDEEDVEEEDEEEEEEEDIPAVKPKVTEKQGGVKRKLDEPTVASKQVKSDGKSIISEEERRRQDRDSRSLFIKEIAKKAKDAEITGLVTGLDSFRRKKNSNFGWLVFNTVADCKKAHDVLSKSKIQGKALYVDFCLSESKAPKEHGVRPINPLQLFINALPGTCNNTDLKNIFRSSTDIKILHASGQPNSKKRAFITFGTVEDAQAAFAKSNGLKVNNHLVDVFYARHQETKVDVKPKKAATPAVQKKIVPKVAADSSGDDSEEVASSDEGIQEVEEEQPKQKKLVKKVEPKTIPRVQQKKPQFKKTGFKGKK
The following text describes a protein:
Function:
Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MSRYFLGSVPQDDPSPAAEEDEDPSSDWSAATPIRPRENIPSSEQYESSDGHISCILSPLDRNIVIPDQSDEPPIPVVLDPTEILLRRYRPESFNNSAASSAANSTTVKASSAGSDANATSNFTNNLDLNTTVIADDPFVEAVCSTPKGRDISGRFEETTPTRGPPAPKPEESYKLSSSPPKATAEKPSITTSIEGLSSQLDILDDLDDDDIDFALTQHTQKKKEVKLTQPTIKKETDIHVLKDIEDLKKTRGSPIKLSKASMGSNIRPLTEVKKVDVKSFIDDLEDEDFDSDLELEFTQVRAKKKPRLQTSRYKLVTDHVMSQRTHKENALPVEIDYKRDDVLRFRIVEVEESSTQIALVVEDSKAQQHRVALRGCWMRAIPCVGDICHLIDESSNDDMDLDFEMDFDYIVDDMKGDMLFILNPDTLVTCTAVAEAHQCTRNVVLKDKMQGPRGIGSIFALLGVIIHETIQMCFGAVRYDAEFVESCAETVTKANMDGIMLSGESFDSVFAKIKDRLPNIVEWFREYMRQTPSAVAIENRTGKKRTLAITKVVDVEEEIWSPRYGIKGKIDATIEVREGNHRYLVPLEVKTGKSTTHIPHRSQTALYTLMLHDRYTCPINFGVLYYSATSETLVIPAVKDEIHNLLAIRNEVASFMRQGSRDMPDVIYDQGQCDRCFQKSECMVYYRLYDTYLKEYMGEDGGATANKARFLQETEHVTEKDSQFFNHWDALLAKEGSDTAVLKREVWTMLSKDREREGRCFSSLIIDNVEKNANSLWYTFKSPDGSEIPYASVNISPGDRVVISDEAGHYCLAMGTLLGSSSETVRCALDRRLEFSLQKLQGFRSNDNQVFQSMLTHSSQSHEAPIDFRFRVDRDDFAFGLGVARNNLFSLFAKHLGTDESPQKIEQLRSWIVDLAPPQPVAGEPTVKLGRLNSDQTRAVHHILNSKDYSLLLGMPGTGKTTTIAEIIMELVKNGKTVLLSSFTHSAVDNILLKLMQHPSCNFDMLRLGSTSKIHPEVAEHYAANNRRNYETREEFEKLFLAPPVVGATALGIGDWVLQERHFDYCIVDEASQITLPFCLGPIRYADKFVLVGDHYQLTPIVKNPEAAGLRESLFKMLCDAHPTQVVNLGIQYRMCADIMLLSNTLIYDGKLKCGSDEVANQSLAVPQLSKLRTLYADGLPNGDYLGHVLDPKRKVIFLNTDLVPAQETIAGDRIHNPTEAVIVGQIVEALCLCGVEDSQIGCISQYRAQLKLINKELALRSGIEVMTADKFQGRDKDCIVVSLVRSNNEQRVGDLLKDWRRLNVAFTRSRSKLIVIGSRATLESFDLLKEFLRLIDDNGWMYSLPKDCTKMYSIVKQGTSPRKKQKRVGLSQRLIDNRPIMKNILEGL
The following text describes a protein:
Function:
A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSYKTEKEAFVSNLNGTTVAEIALVNASAPLAVLLRAVVIPWLFGQMYSKFNIGQANKNGSTHRKPSKPAHTHSNPSKPAQTHSNMSKPTQTQSVSLQTILDRKLSETVPFVTNYRAYANIATAICILAVDFHIFPRRFAKAEMYGTGLMDAGVGSFVVSNAIVSPEARGKYRMARSLSGKLSNIAQSVRSTAPLWMIGLSRMVVVKALDYQEHVTEYGVHWNFFFTLAVVRVLSTAVLQFTGAGMSGLLSLVLAVQYQFALSNQGLQEFVLHGSDGRDSRRGFLDANREGICSCWGFLAVYFTGVELGRFIFRKRSTVQQWLVGCVQLLVSCGVFWVLLVLCEEYVEPVSRRTANLPYQLWMMVYNIQIIGSMLLVDLVVVIAAELRLLKREYSPRIWGVEPTTGDSKDAVPTEQQLPDWCLLSAVNRNQLFFFLLANLLTGAVNLCVDTLHTEPFMAFCIVFAYMLQLCNVVVVLHARNISLKFW
The following text describes a protein:
Function:
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
Subcellular Localization:
Cytoplasm.
Sequence:
MLVIIRPSGEIALKSPRSRRNFEYTLINNIRNTIGGGKIWRSQGVILLEVNDNNANIEALSEVFGISSFSPVIAIKSNNLEDIVNKAKEIFAEIVKGKIFAVRAKRIGSHSFTSLDVERRAGEALYPYSKGVDLENPEVEIFIEIRNEMTYFYHKVIKGPKGLPVGVAGKTVVLFSGGIDSPVATWMMMKRGSVPIILNFNLGGDLHKELVLKELNMLKRWSGGHKLKIFIVKGTDVFIKLSQVERRSRVVMLKRVMYKTAEKLCEKTNAKSITTGESLSQVSSQTMANLYVTEYGIKYPIFRPLIGFDKEEIVDIARKIGTYKHSIKLPEYCAISTKARTSEDLNEILKNEERLNVDYEKILENSEVIEL
The following text describes a protein:
Function:
PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression.
Subcellular Localization:
Nucleus.
Sequence:
MFWGIEISKVPVKFTPAFDLHITTACLSAVAKDTGRNVLQVKYDGKTYSLCSLKLNATEHSVLDTNFEEGKEVEFSVSGNNTICLTGYFVDSMFGDDEHGEDEDNEEEEGEEGEDEEMEGEDEDEDEEDEDEEDEDEEEEDDEEDDEINKELERQILEQALKRKAQIEADKNKQQKKPKQEEPVKQVTPVKPTAQAAKPTAATTTTTTTTTTTPTKQTTPAKPAAKPVTPTKPVTPTKPVEAAVVEKKKPTSSVVTLPSGLQYEDLVVGSGPSPKSGKKVGVKYIGKLTNGKTFDSSLRTPFTFRIGIREVIRGWDIGVASMKVGGKRRLTIPADLAYGRSGAPPSIPPNATLIFDVELVSCAQ
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MVSYVKGPAYKALSHFGKLNAPLVRSYIPNLVFWGAAAGGAVATFTEGVPLFQKTFYEKIPFFGQHWIYNPDPEDVPV
The following text describes a protein:
Function:
Involved in beta-methylthiolation of ribosomal protein S12.
Sequence:
MTQTFIPGKDAALEDSIARFQQKLSDLGFQIEEASWLNPVPNVWSVHIRDKECALCFTNGKGATKKAALASALGEYFERLSTNYFFADFWLGETIANGPFVHYPNEKWFPLTENDDVPEGLLDDRLRAFYDPENELTGSMLIDLQSGNEDRGICGLPFTRQSDNQTVYIPMNIIGNLYVSNGMSAGNTRNEARVQGLSEVFERYVKNRIIAESISLPEIPADVLARYPAVVEAIETLEAEGFPIFAYDGSLGGQYPVICVVLFNPANGTCFASFGAHPDFGVALERTVTELLQGRGLKDLDVFTPPTFDDEEVAEHTNLETHFIDSSGLISWDLFKQDADYPFVDWNFSGTTEEEFATLMAIFNKEDKEVYIADYEHLGVYACRIIVPGMSDIYPAEDLWLANNSMGSHLRETILSLPGSEWEKEDYLNLIEQLDEEGFDDFTRVRELLGLATGSDNGWYTLRIGELKAMLALAGGDLEQALVWTEWTMEFNSSVFSPERANYYRCLQTLLLLAQEEDRQPLQYLNAFVRMYGADAVEAASAAMSGEAAFYGLQPVDSDLHAFAAHQSLLKAYEKLQRAKAAFWAK
The following text describes a protein:
Function:
Acts as a chaperone for histones, such as histone H2A-H2B, and thus regulates the assembly of nucleosome cores. Involved in chromatin remodeling, especially during fertilization and early embryonic development. May be involved in sperm chromatin decondensation during fertilization.
Subcellular Localization:
Nucleus.
Sequence:
MASTASNTSKVEKPVSLIWGCELNEQNKTFAFKIEDEEEKCEHQLALRTVCLGDKAKDEFHIVEIVTQEEGKEKPVPIASLKPSILPMATMVGIELTPPVTFRLKAGSGPVYISGQHVAMEEDYSWAEEEDEGEEEEEEEEDPESPPKAVKRPAATKKAGQAKKKKLDKEDESSEEDSPTKKGKGAGRGRKPAAKK
The following text describes a protein:
Function:
Involved in the final stage of protein secretion.
Miscellaneous:
MISCELLANEOUS: Present with 639 molecules/cell in log phase SD medium.
Sequence:
MSDLIELQRNYLIGVLNQIETKNNLKFLIIDKTVETILSYLFLTPQELLNNVTSVDLIDSPTRKGQSSIEAIYILEPTKYNINCIDADFMVRPPKYRRCHIRFLPGLTNPIFQFFQSKRYIAQNLESFKPIELGFFVKESQFFETLQMEHSLQVFFNNNCKALIPTNVRKIVGSLVSLCVITGEYPIVRYSVSNPVEEEDARNGNAVVNANSLTRSIANAFQIAIDTYARNNPDFPPQNTERPRSILIITDRTLDPFAPILHDFSYQAMAYDLVANVDTQKDIYHYSAENEAGEQEEKVSKLVDLYDPDWIDLKHQHIMDANEYIQGRIKELIAKNPLLVDRSNVKNTTDLLSVVAHLKDFDEERRRLILHKTLVDECLGENAERKLADISAIEQNLSGFGMDFSGEKIKHIIDDLLPALAMKEPTILDKLRYIIAYALFRGGIIELDFIKLLNFIGVTHEHENFQQYLKIFRNYDLIDFKLIKDKPKDKPFQKEWFHDTLVNDPNIYHTSRFVPAVGNILSKVIANPLLLSEQYFPYLKDKPIELLNEEEFQAGLANTSANSSSSLRNPRHKAAWTTKSSNIKKNIPRQRFFYYVIGGISIPEIKAAYDQSNLKNRDIFIGSDEILTPTKFLDEVERLQNPREFFKFKEDQRQQVNPPDFLLREMKPVAQPVSHVHLKSQDNSPKSGTSSPKAAGSLKSEPPEKEKKRSKFSRFLKRKSHHDK
The following text describes a protein:
Function:
Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity.
Subcellular Localization:
Cell projection, stereocilium. Cell projection, kinocilium. Cytoplasm, cytoskeleton. Note=Also present in the cuticular plate of auditory hair cells. In the organ of Corti, in inner hair cells, expressed along the length of the stereocilia, but excluded from the very tip. Colocalizes with F-actin cytoskeleton.
Sequence:
MSETSCSFFIEKEFQDGQLENVSAGLSSSYKDKGALMAFRGIPISELTNHGILQALTAETNGWQPGVVSEEVLRAQEEWEVVDTIHPDIESGVHCQQPGQLISFNEALEHFQSVDLSSFKKRIQPTIQRTGLAALRHCLFGPPKLHQGLREERDLVLTIAQCGLDSQNPTHGRVLQTIYKKLTGSKFDCALHGDHWEDLGFQGANPATDLRGAGFLALLHLLYLVMDSKTFLMAQEIFRLSHHHIQQFPFCLMSVNITRIAIQALREECLSRECNRRQKVIPVVNSFYAATFLHLARVWRTQQKTILDSGFVLKDLEALAKKSPKRLLKTLDDYLAQVSKGQTSLLEAHKRPGSQGPHSRDLTFTGVCDLQSHSFESAGLI
The following text describes a protein:
Function:
[Ninjurin-A]: Effector of non-apoptotic necrotic cell death that mediates plasma membrane rupture (cytolysis): oligomerizes in response to death stimuli and promotes plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane, leading to release intracellular molecules that propagate the inflammatory response. Also acts as a homophilic transmembrane adhesion molecule that promotes cell adhesion by mediating homophilic interactions via its extracellular region (By similarity); [Secreted ninjurin-A]: Secreted form generated by cleavage, which acts as a negative regulator of cell adhesion. Promotes the loss of cell adhesion in a cell non-autonomous manner.
Subcellular Localization:
[Ninjurin-A]: Cell membrane; Multi-pass membrane protein; [Secreted ninjurin-A]: Secreted.
Domain:
[Ninjurin-A]: Composed of 4 alpha helices: 2 hydrophobic transmembrane regions (alpha3 and alpha4) and 2 alpha helices (alpha1 and alpha2). Alpha1 and alpha2 feature one hydrophobic side and a hydrophilic side. In normal conditions, NijA is inactivated and alpha1 and alpha2 helices are not inserted into the membrane. Following NijA activation, alpha1 and alpha2 helices insert into the membrane and drive NijA oligomerization via interactions between alpha3 and alpha4 and the hydrophobic face of alpha1 from an adjacent subunit. Such structures disrupt membrane integrity and form a lesion through the introduction of the hydrophilic faces of alpha1 and alpha2 into the hydrophobic membrane.
Sequence:
MSNLEHITLEMDKVPLGDNKTLVRNTENISKHSYGGAIDGRTRNTLRVPRAVPETDDDDNDDRPFVKDGNDNPGVDDGLFSTVGGNGGNGGNVNVNVPNGGRRPSFSFPGYNGPGFVTINGVETPIPDVNAYQHKKTLAQGMMDLALLSANANQLRYVLETSSQHPYFYPSLLFISLSIIFQIAVGVGLILNGQYNIKNGHDICRANRINNYTVSGIFIVTVVNVLISAFTVDRDTVPALPANTT
The following text describes a protein:
Function:
Transports trehalose monomycolate (TMM) to the cell wall. Flips TMM across the inner membrane. Membrane potential is not required for this function. Transports probably phosphatidylethanolamine (PE) as well. Binds specifically both TMM and PE, but not trehalose dimycolate (TDM). Also binds diacylglycerol (DAG) and other phospholipids, including phosphatidylglycerol (PG), phosphatidylinositol (PI), and cardiolipin (CDL). Contributes to membrane potential, cell wall composition, antibiotic susceptibility and fitness (By similarity). Could also be part of a heme-iron acquisition system; Is the target of the antitubercular drug SQ109.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell septum. Cell tip. Note=Colocalizes with TtfA to the cell poles and septa. Trehalose monomycolate (TMM) synthesis is not required for localization to the poles or septa.
Sequence:
MFAWWGRTVYRYRFIVIGVMVALCLGGGVFGLSLGKHVTQSGFYDDGSQSVQASVLGDQVYGRDRSGHIVAIFQAPAGKTVDDPAWSKKVVDELNRFQQDHPDQVLGWAGYLRASQATGMATADKKYTFVSIPLKGDDDDTILNNYKAIAPDLQRLDGGTVKLAGLQPVAEALTGTIATDQRRMEVLALPLVAVVLFFVFGGVIAAGLPVMVGGLCIAGALGIMRFLAIFGPVHYFAQPVVSLIGLGIAIDYGLFIVSRFREEIAEGYDTETAVRRTVITAGRTVTFSAVLIVASAIGLLLFPQGFLKSLTYATIASVMLSAILSITVLPACLGILGKHVDALGVRTLFRVPFLANWKISAAYLNWLADRLQRTKTREEVEAGFWGKLVNRVMKRPVLFAAPIVIIMILLIIPVGKLSLGGISEKYLPPTNSVRQAQEEFDKLFPGYRTNPLTLVIQTSNHQPVTDAQIADIRSKAMAIGGFIEPDNDPANMWQERAYAVGASKDPSVRVLQNGLINPADASKKLTELRAITPPKGITVLVGGTPALELDSIHGLFAKMPLMVVILLTTTIVLMFLAFGSVVLPIKATLMSALTLGSTMGILTWIFVDGHFSKWLNFTPTPLTAPVIGLIIALVFGLSTDYEVFLVSRMVEARERGMSTQEAIRIGTAATGRIITAAALIVAVVAGAFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVPSVMKLLGDDCWWAPRWARRLQTRIGLGEIHLPDERKRPVSNGRPARPPVTAGLVAARAAGDPRPPHDPTHPLAESPRPARSSPASSPELTPALEATAAPAAPSGASTTRMQIGSSTEPPTTRLAAAGRSVQSPASTPPPTPTPPSAPSAGQTRAMPLAANRSTDAAGDPAEPTAALPIIRSDGDDSEAATEQLNARGTSDKTRQRRRGGGALSAQDLLRREGRL
The following text describes a protein:
Function:
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A.
Subcellular Localization:
Lysosome.
Sequence:
MTRFQGSTGSVFIGPFRETPQSLWEVPLVSSPGKISSSGVSFCLSCVFLLLLRCVPGAQGVWPMPQRVVQSEVRYPLSPHDFTFQYGKESAVQQGCAVLDVAFKRYFSLTFTGYANVRTGTEKHKVSPYGGHRFGTAPPTGLVVTVKEPGCDGYPDLDSKENYNLTVADGPGVLIADSVWGALRGLETFSQLVYQDDDNTYYVNKTEVQDYPRFQYRGLLLDTSRHYLPLSAILKTLDAMAYSKFNVFHWHIVDDPSFPYQSPTFPELSNKGAYHPQTHIYTVTDVKRVIEHARLRGIRVVPEFDTPGHTQSWGKGQLGLLTPCYKGSVPSGSFGPVNPALNSSYQFMSTLFKEVSVVFPDSYIHLGGDEVDFTCWQSNPDIQIFMAKMGFGTDYRKLESYYIEKCPRTRSCMCGRVIQHSTSMR
The following text describes a protein:
Function:
Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion. Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MALVALVAGARLGRRLSGPGLGRGHWTAAGRSRSRREAAEAEAEVPVVQYVGERAARADRVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSTDGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVRLAGEVLRMDAKSRVT
The following text describes a protein:
Function:
Probable retinal pigment epithelium (RPE)-specific proton-coupled L-lactate transporter (By similarity). May facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina (By similarity).
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein. Note=Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression. Colocalizes with BSG in basolateral cell membrane of the retinal pigment epithelium (By similarity).
Domain:
The two basolateral sorting signals (BSS) are required to direct SLC16A8 to the basolateral membrane.
Sequence:
MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRRRLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALEVLSARGEPTEPEIEARPRLAAESV
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSTDAVAVIGFVSLFALMLLRVPVGMAMGLVGVSGFSYLVGATPALKLVGQTSMRTVTDYTFGVIPMFLLMGSFVSNSGMSRELFRAANGFVGHLRGGLGIATVGACGGFAAICGSSVATAATFSAVAYPEMRRFGYPQSFATGVIAAGGTLGAMLPPSTVLAVYGIITEQDIGKLFIAGIIPGLLAMTMYMITIALIGYFRPDFLPKGKVLPWRERFAGLKEIWAPVLLFVFVIGGLYGLPFLPRFTPTEAGGVGATGAFIIGVFTGRLDREKILASLLQATRTAAAVFTVLIGALIFGYFLTVTQTPQKVTEFLTGLGLGPYGVLALIMVMYLVLGCLMDAMAMIILTVPIIFPVIMHLGFDPIWFGVIIVMTVELGLIHPPVGMNVFVIKSVVKDVSFSTIFKGVIPFVATDLVRLVILIAFPLLATWLPTRMMAH
The following text describes a protein:
Function:
Defense against chitin-containing fungal pathogens.
Sequence:
MRFWALTVLSLLLSLLLGVSSDTAQCGSQAGNATCPNDLCCSSGGYCGLTVAYCCAGCVSQCRNCFFTESMFEQMLPNRNNDSCPGKGFYTYDAYFVATEFYPGFGMTGDDDTRKRELAAFFAQTSQETSGRSIIGEDAPFTWGYCLVNELNPNSDYCDPKTKSSYPCVADYYGRGPLQLRWNYNYGECGNYLGQNLLDEPEKVATDPVLSFEAALWFWMNPHSTGAPSCHEVITGEWSPSEADIEAGRKPGFGMLTNIITNGGECTKDGKTRQQNRIDYYLRYCDMLQVDPGDNLYCDNQETFEDNGLLKMVGTM
The following text describes a protein:
Function:
Heavy-metal-binding protein.
Sequence:
MSKEEFMKIQTCVLKVNIHCDGCKQKVKKILQKIEGVFTTKIDAELGKVTVSGNVDPSVLIKKLLKSGKHAEIWGAPKGGSNNNQNQPNLANQFKAMQIDHGGKGGGGGGGGPANNNKGQKIGGGGGGGGGGGGGGGGGPPKMVIPQLTPQQMQQLNPQQLQQLQQLQQMKGFQDLKLPPQLKGGPGPGPGSVPMNKNPQMPNNPNQKAVKFNVPDDDDEEDFSDEFDDEFDEDDDEFDDDLEDDEFDDHPPPPNKMKPMMGGGNMIMPNNMMPNMMMPNAQQMLNAHKNGGGPGPAGGKIEGKGMPFPVQMGGGGGGPGGKKGGPGGGGGNMGNQNQGGGGKNGGKGGGGHPLDGKMGGGGGGPNGNKGGGGVQMNGGPNGGKKGGGGGGGGGGGPMSGGLPPGFRPMGGGGGGGGGPQSMSMPMGGAMGGPMGSLPQMGGGPGPMSNNMQAVQGLPAMGPGGGGGGGPSAEAPPGYFQGQVSGNGGGGQDSMPGNPYLQQQQQQQQQQYLAAVMNQQRSMGNERFQPMMYARPPPAVNYMPPQPQPHQQHPYPYPYPYPPQYPPHNGDQYSDYFNDENTSSCNIM