lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Glutathione S-transferase; part of the gene cluster that mediates the biosynthesis of gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide bridged cyclic dipeptide. The first step in gliotoxin biosynthesis is the condensation of serine and phenylalanine to form the cyclo-L-phenylalanyl-L-serine diketopiperazine (DKP) by the NRPS gliP. GliP is also able to produce the DKP cyclo-L-tryptophanyl-L-serine, suggesting that the substrate specificity of the first adenylation (A) domain in gliP is sufficiently relaxed to accommodate both L-Phe and L-Trp. The cytochrome P450 monooxygenase gliC has been shown to catalyze the subsequent hydroxylation of the alpha-carbon of L-Phe in cyclo-L-phenylalanyl-L-serine whereas the second cytochrome P450 enzyme, gliF, is presumably involved in the modification of the DKP side chain. The glutathione S-transferase (GST) gliG then forms a bis-glutathionylated biosynthetic intermediate which is responsible for the sulfurization of gliotoxin. This bis-glutathionylated intermediate is subsequently processed by the gamma-glutamyl cyclotransferase gliK to remove both gamma-glutamyl moieties. Subsequent processing via gliI yields a biosynthetic intermediate, which is N-methylated via the N-methyltransferase gliN, before the gliotoxin oxidoreductase gliT-mediated disulfide bridge closure. GliN-mediated amide methylation confers stability to ETP, damping the spontaneous formation of tri- and tetrasulfides. Intracellular dithiol gliotoxin oxidized by gliT is subsequently effluxed by gliA. Gliotoxin contributes to pathogenesis during invasive aspergillosis. In macrophages and neutrophils, gliotoxin showed inhibition of various different cell functions including cytokine production, antigen presentation, phagocytosis, and production of reactive oxygen species.
Sequence:
MSERPSDLVVNRLVLFVVKGTATSTHNTVKPLILLEELGVPHDIYVVEKVSAPWFSEINPHKMVPAILDRSPDGRDTLRAWESTSTLMYIADAYDKDGTLGGRNVQERSEINNWLTLHTAALGPTAKYWLYFYKLHPEKLPKTIEKLRSNITVQYDILERRLNEPGQQYLALKDRPTIADIATLPFAMKSTAELFGLEFEKWPKLQEWSVRMGEREAVKRAWQRVAGFGHGEKEYGMLEA
The following text describes a protein:
Function:
Involved in 20S proteasome assembly.
Sequence:
MNLIIPSVSCGNIPQLTVDLLIHSLDFSLVSRLDDSYLHPFASPVDHVEGQQVESGHVATAIELYRSEKLDTDVIQIRSPPIADFKQAFSAQLEELTKKYTNVIVLGSSDAGLREQVGAPKIEYYTSDLATRFQTLSLDGPKVKEVPAVLPGSGYFRSLVKGPALGLVFFAYEGDNFGDAHQLADAVIRLLGGSEMKWTQPVSWQGAYGHDAPLGVEQGVYC
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Subcellular Localization:
Cytoplasm.
Sequence:
MGCVSMTLGIDEAGRGCLAGSLFVAGVACNEKTALEFLKMGLKDSKKLSLKKRFFLEYKIKTHGEVGFFVVKKSANEIDSLGLGACLKLAVQEILENGCSLVDEIKIDGNTAFGLNKRYPHIQTIIKGDETIAQIAMASVLAKAFKDREMLELHALFKEYGWDKNCGYGTKQHIEAIIKLGATPFHRHSFTLKNRILNPKLLEVEQRLI
The following text describes a protein:
Function:
Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro. Essential for viability and secretion; Has a direct role in controlling cell septation and in forespore membrane formation.
Subcellular Localization:
Nucleus. Prospore membrane. Note=Nuclear, during meiosis. Associated with the forespore membrane during sporulation. During interphase found at the cell poles and during M-phase is located at both the cell poles and the medial region.
Sequence:
MSETISDPYPLTNPNAPLGHPGHLNSTQQATLDSMRLELQKLGYTERLDDATLLRFLRARKFNLQQSLEMFIKCEKWRKEFGVDDLIKNFHYDEKEAVSKYYPQFYHKTDIDGRPVYVEQLGNIDLKKLYQITTPERMMQNLVYEYEMLALKRFPACSRKAGGLIETSCTIMDLKGVGITSIHSVYSYIRQASSISQDYYPERMGKFYVINAPWGFSSAFNLIKGFLDEATVKKIHILGSNYKSALLEQIPADNLPAKLGGNCQCPGGCELSDAGPWHEEQWMNKN
The following text describes a protein:
Function:
Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSKHSEDPIKGVKVQKRKVASIASTSSSTSTHQQLMNQATKMKRTKINEMKKQKQDFFKRINYSHLLTVVVLPLLAVLYVVLCKQSIVPENERTLYFTCIYYNITMLAFTSGYHKYFAHNSFKVKAELLKYYFCIFGSSCGLGSVRWWAGLHRAHHHFTDDTERDPYSIKRGFLFSHYAWLLKKPKLTKFYLDFLEQEFPEHAENQKVQNEIVLDKEIETEYNGEDIMRQNYDESLRNLLMWQQRTYLFWFFVTTILIPALITKYVCGDSIVHGILYPGILRMFLCQQSLLSTESICHLKRIQVTIPTQPFNDKNSSTNCNNPLVSFLTYGQSHQNYHHEFPHDYRVDNSYLTYDPTKWFIWILEQLGAVDELSRTPGNLIVQLKLQQQQLIINRTKSQLNWGTPISKLPLISPSDFKKIISSTSNKDRIYIVIQNIIHDITPFMDQHPGGVALLKASHGKDATKAFYGGVYGHSTAAVNLLATMRIGVLDDGDDEEVWRRVAREEREVSNSTDSRPGHHHTAEAA
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MWYNNIKHIMASCGYSEDVRLSRLLIGAIVIIITLFDQFYNEKFPDNKNYLIGFWVHYVSKITCLILDYCTYVIFNGILQLIVYTKEKNTILFTYPPAGSIYKSTGLMISSKLPRFSDMYTLTIASADPKSISAHPTVEVTKSGATVLTPNVPYISVVLLEDIRLRKLIDTMALYVLDGGYAFEQAIMERVRGNPLFSFLFELGSKEHTYYVWRLYSFAQHVGTERTLTGAQRDEFEDMLHALTLERIQVKEAMGKTIINLNKTNVLVLLKQLYWLQNTVNDPWKIKRSW
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MAAVLLSNTMAQNHNSNVNNDVKPTIFHDFLGRDCPPVPNCAAAGDASAAGSPSASASRAGGPISTTSDLGSDRQVGSHLEGVPFYGQKSDFSGSDIGNRYAGNKRSNSDSVFLSSSRDSSHLMKMLRNVGQEQQPMRPILQQATVANGKPDSNPSNSKWERAIPVNVGPVLQYPSRTGQPLPYPYQQTLSNRFKDPTMGTSVISQSAADEGSRTGIKGSGILNSGNVSGVGEPKHKSGISVPEPGSSAPLRRLGSTSVSRQMTIFYGGQAHVFDDVHPNKVSSKVVFGMMESGKEWNADAIMAMAGSSGGSWSTNYSQNPSIKPFIGIGDNNTLSRERLNSTHGTGLSDRIPSIHGGHSGVLMTDARRLSQATEEKP
The following text describes a protein:
Function:
Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body. Acts as a nuclear repressor of the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock components. Inhibits circadian clock function in cancer cells, when overexpressed.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Due to intron retention.
Subcellular Localization:
[Isoform 1]: Nucleus. Note=Associates preferentially at the periphery of the nucleus with heterochromatin; [Isoform 2]: Nucleus. Note=Associates preferentially at the periphery of the nucleus with heterochromatin.
Domain:
C-termini of isoform 1 and isoform 2 are sufficient to interact with and to repress the activity of CLOCK-BMAL1.
Sequence:
MKMRGEKRRDKVNPKSSQRKLNWIPSFPTYDYFNQVTLQLLDGFMITLSTDGVIICVAENISSLLGHLPAEIVGKKLLSLLPDEEKDEVYQKIILKFPLLNSETHIEFCCHLKRGNVEHGDSSAYENVKFIVNVRDICNEFPVVFSGLFSSHLCADFAACVPQEDRLYLVGNVCILRTQLLQQLYTSKAVSDEAVLTQDSDEEPFVGELSSSQGQRGHTSMKAVYVEPAAAAAAAAISDDQIDIAEVEQYGPQENVHMFVDSDSTYCSSTVFLDTMPESPALSLQDFRGEPEVNPLYRADPVDLEFSVDQVDSVDQEGPMDQQDPENPVAPLDQAGLMDPVDPEDSVDLGAAGASAQPLQPSSPVAYDIISQELELMKKLKEQLEERTWLLHDAIQNQQNALELMMDHLQKQPNTLRHVVIPDLQSSEAVPKKQQKQHAGQVKRPLPHPKDVKCFCGLSLSNSLKNTGELQEPCVAFNQQQLVQQEQHLKEQQRQLREQLQQLREQRKVQKQKKMQEKKKLQEQKMQEKKKLQEQRRQKKKKLQERKKWQGQMLQKEPEEEQQKQQLQEQPLKHNVIVGNERVQICLQNPRDVSVPLCNHPVRFLQAQPIVPVQRAAEQQPSGFYQDENCGQQEDESQSFYPEAYQGPPVNQLPLIDTSNSEAISSSSIPQFPITSDSTISTLETPQDYIRLWQELSDSLGPVVQVNTWSCDEQGTLHGQPTYHQVQVSEVGVEGPPDPQAFQGPAAYQPDQMRSAEQTRLMPAEQRDSNKPC
The following text describes a protein:
Function:
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform 6]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform 7]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform 12]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein; [Isoform 2]: Cell membrane; Single-pass type I membrane protein; [Isoform 9]: Cell membrane; Single-pass type I membrane protein; [Isoform 11]: Cell membrane; Single-pass type I membrane protein; [Isoform 3]: Secreted; [Isoform 4]: Secreted; [Isoform 5]: Secreted; [Isoform 6]: Secreted; [Isoform 7]: Secreted; [Isoform 8]: Secreted; [Isoform 10]: Secreted; [Isoform 12]: Secreted.
Sequence:
MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAPCTEPCGNSTCLVCPQDTFLAWENHHNSECARCQACDEQASQVALENCSAVADTRCGCKPGWFVECQVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCLPGFYEHGDGCVSCPTSTLGSCPERCAAVCGWRQMFWVQVLLAGLVVPLLLGATLTYTYRHCWPHKPLVTADEAGMEALTPPPATHLSPLDSAHTLLAPPDSSEKICTVQLVGNSWTPGYPETQEALCPQVTWSWDQLPSRALGPAAAPTLSPESPAGSPAMMLQPGPQLYDVMDAVPARRWKEFVRTLGLREAEIEAVEVEIGRFRDQQYEMLKRWRQQQPAGLGAVYAALERMGLDGCVEDLRSRLQRGP
The following text describes a protein:
Function:
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, and mRNA stability. Recruited to promoters upon gene activation, methylates histone H3 and activates transcription via chromatin remodeling.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASSPDLFPNVAFSDVSAPADVPAAEGATAAFGLGAATGAPRLSLVKAGKAEAESTVEIDLADAQVFKLGPREWLCVCDESEAKAGVEVKSFSRAIKVVLRTEAESKAFSLAFQRWKHQVISGKAGERLENGSIIASKSKFDTKIEASSAKMYFHYYGQLLHQQNMLQDFVRTGTYYAAVMENRSDFEGRIVVDVGAGSGILSLFAAQAGARHVYAVEASEMAEHAQRLISGNPSLGQRITVIKGKVEEVELPEKADILISEPMGTLLVNERMLESYVIARDRFLAPDGKMFPTTGRIHMAPFSDEYLYVEMANKALFWQQHNFFGVDLTPLHGSAFQGYFSQPVVDAFDPRLLISPPTYHTLDFTSMKEEELYEIDIPLSFVASVGTRVHGLACWFDVLFNGSTVQRWLTTAPGSPTTHWYQLRCVLSQPLYVMAGQEITGRLHLVAHSSQSYTIYLTMSAKMWGVGAEQGGILQTSTGKLELKEPYYRLSQPQSYMLPQDQQQQQLPSLQAQGSEQQMQEGLSPGITIDQVDQDCGLN
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Sequence:
MSTKPILLLGDEILYRISEEIQKSNLDKAKQVINDLHDTIVSFKNRYGFGRAIAAPQIGESVRIIYMHLGDKTHYFINPILEFIGEDTFHLWDDCMSFPGLEVYVERHKKCKVTYKNLSWEDCEMYLEGDLSELFQHEYDHLDGILAVQRAKDLKSFRINKNKSGY
The following text describes a protein:
Function:
Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during embryonic development and for the phagocytic elimination of S.aureus by mediating the binding of S.aureus peptidoglycan to larval hemocytes, which probably activates a signaling pathway involving Rac1 and Rac2. Not required for the production of antimicrobial peptides during S.aureus. Upon activation by LanA, integrin alpha-PS3/beta-nu activates Fak in presynapsis to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with LanA, glutamate receptor-modulated NMJ growth.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MTSLGGRAFLWIYLVFLIAEISHSDADSIDDQCRHADSCERCLSAHLECAWCTDKEYQVGYRCLSRRQLLNYNCSETDIYENQPVLDVLQDKPLKDYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMILPQHRENPCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQFADNSPDFIDMAYYTDCGGQFPSLQKRNYCNNVTLGKQIDFYVDVTLKKYPDNQVYTHKIRVEETSLSEFMDLDVELQRPCPCQETPDPENEEGRFLCDYKGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQKCRQPFSDKSTSELVCSNHGDCDCGTCLCDPGYTGPFCECRECLDCDEKLADCFCGQCVCKYGWSGSKCNCDGDTDACVGPTGEICSERGTCQCEECQCEEPYLGKFCEIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCENLTEICSSLDRQETYPYNFVHELDPEQDQCLVRLVNKHGIQCDSFFVYQVIDHSNFLTIQAVDCEPPDYVALVGYISAFTLLIGLLIIFIILWYIRAKDAREYAKFEEDQKNSVRQENPIYRDPVGRYEVPKALSVKYDENPFAS
The following text describes a protein:
Function:
May be an inorganic phosphate cotransporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNDMEEIPKTVPRLGLRHLQAGLLFYGLAANTVLQLNVSVAVVAMTNETTSNNSDPPHYNWSEEKKSYILSSYYWGCALAQFPAGYLCKRFGSKAVLFWGTLGSSLLSALTTYGVYAGGWKAYCAIRLLQGLCQVTWPCIHQHLANWCPTAERTRLGAFAYTGFDCGNVLAMYGAGMIASSSLGWPGISYSAAGLGLIWCGLWLLLGANKASDARFIGEAEKAYIVGDIQRSERKGPKKMEIPWKGIFTSVPVYALLCARCADSWGLTTMQTELPTYLSGVLKLDMKSNAVFSALPFLLMWVMCYVYLIIADVLLRKKWMSLTTLRKTYTSIALWAPASIMLSLVIVGEGQKTLVLVLVTLSVGVSSAATIGSELNTIDLSPNHAGILAGLMSSFTNLMALLTPLVVGVLVTDPSQRSQWQIVFSLAAGVLFTGNVIFLIWGTAVTQPWNESKESRRELEPEEKPFHRAKLEIGTDNTDGNVVGLKLNCTSP
The following text describes a protein:
Function:
Selective L-arginine transporter that is essential for parasite survival and virulence. Does not require other inorganic ions such as sodium, chloride, potassium or calcium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAGLLSSCCGRVYALLPDSAHPSAQQKTPFGVNRYVLLVIYMIYALLTSSVYFGWRSMSAMLFKSGQFSWVCTGESADTSPEEGETDYLCALQDTKVQSLFTIAMACHFTCSAVAGYLLDTVGPKAVALLGQTFNALAWILLAFSGPNFRSVYPAFVFMGAGADVSVYPTLLIVNLFPGSTALIMATLGACISLSFFVPLVLRTMWESTGISFEAVCIGYAVAGPILCAVVAFFFIPFKAFKGVDNFSACVEAEKLANSPTAQSSPKAVDSPPCDEGASSRGRLAVSHNTERTAPDDEQEKDNTERISLSDLACDPRFKKQKVSFSSQAFTFLYFGICLYFTVCGWVMAYYQEAAGRFLCNDAEYTLEILTPLSTIPCLLFGVVINRIGIMPVILMLNTIGLLTYVCVVAAESVVAQYFSVIFFFMYISIFTTQMYVFVESTFDSAHFGKLIGVASLIGGLLSLISNVLYGDVTVGMLNGDTRPVVIALLAVIILMYPILLAMRTKRNRKKQMEQEDIRSRVLELKAAHAADAA
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Sequence:
MVSAQLHFLCLLTLYLTGAYGQEGKFSGPLKPMTFSIFEGQEPSQIIFQFKANPPAVTFELTGETDGIFKIEKDGLLYHTRVLDRETRAVHHLQLAALDSQGAIVDGPVPIIIEVKDINDNRPTFLQTKYEGSVRQNSRPGKPFMYVNATDLDDPATPNGQLFYQIVIQLPKINNVMYFQIDNKTGAISLTPEGSQVLDPIKNPYYNLVVSVKDMGGQNENSFSDTTSVDITVRENIWKAPEPVEIRENLTDPHPIKITQVQWNDPGAHYSLINKEKLPQFPFSIDQEGNIYVTQPLDREEKDSHVFFATAKDENGKPLAYPLEIRVKVIDINDNPPTCLSQVTVFEVQENEVLGSSIGIFAAHDMDEANNINSILKYRLVDQTPKVPSDELFLIDEYGGKVQLGKRSLKKQDSPQYNLTVEVSDIDFKTLCSLQVNVIDINDQIPIFERSDYGSKTLSEDTAIGSTILIIQATDDDEPFTGSSKILYKIVQGDTEGRLEVVTDPMTNTGYVKIRKPLDFETEPVTSIVFKAENPEPLVNGIEYNASSFASFELTVTDVNEVPVFPQQIFQANVSEDTAIGTKVGTVTARDPEGLTVSYSLKDNKRGWLKIDSVTGDIFSTAPLDRETESVYRVQVVATEVGGSSLSSTAYFHLVLMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQQSVRRPKFTFALGRESLQSDWEVSKINGTHARLSTKHTRFEEQVYDIPILINDGGQPPMEGIVSLSVTFCQCVDGSCFRPAGNQVGIPTVGMAVGILLTTFLVIGIILAVVFIRMRKDKVEDPQSPENKPLRS
The following text describes a protein:
Function:
Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MQLKHLRTLLSPQDGAAKVTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRKSYMVKGMAFSPDSTKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQTSAVTCLQWPAEYIIVFGLAEGKVRLANTKTNKSSTIYGTDSYVVSLTTNCSGKGILSGHADGTIVRYFFDDEGSGESQGKLVNHPCPPYALAWATNSIVAAGCDRRIVAYGKEGHVLQTFDYSRDPQEREFTTAAASPGGQSVVLGSYDRLRVLNWSPRRSIWEEAKPKEIANLYTITALAWKRDGSRLCAGTLCGGVEQFDCCLRRSIYKNKFELTYVGPSQVIVKNLSSGTRVVLKSHYGYEVEEVKILGKERYLVAHTSDTLLLGDLNTNRLSEVAWQGSGGNEKYFFENENVCMIFNAGELTLVEYGSNDTLGSVRTEFMNPHLISVRINERCQRGMEDNKKLAYLVDIKTIAIVDLIGGYNIGTISHESRVDWLELNETGHKLLFRDRKLRLHLYDIESCCKTMILNFCSYVQWVPGSDVLVAQNRNSLCVWYNIEAPERVTMSSIRGDVVGLERGGGKTEVMVTEGVTTVAYTLDEGLIEFGTAIDDGNYTRATAFLETLEMTPETEAMWKTLSKLALEARQLHIAERCFSALGHVAKARFLHETNEIADQVSREYGGEGTDFYQVRARLAMLEKNYKLAEMIFLEQNAVEEAMDMYQELHRWDECIAVAEAKGHPALEKLRRGYYQWLMDTQQEERAGELQESQGDGLAAISLYLKAGLPAKAARLVLTQEELLANTELVEHITAALIKGELYERAGDLFEKIRNPQRALECYCKGNAFMKAVELARLAFPVEVVRLEEAWGDHLVQQKQLDAAINHYIEARCSIKAIEAALGARQWKKAIYILDLQDRNTASKYYPRVAQHYASLQEYEIAEELYTKGDRTKDAIDMYTQAGRWEQAHKLAMKCMRPEDVSVLYITQAQEMEKQGKYREAERLYVTVEEPDLAITMFKKHKLYDDMIRLVGKHHPDLLSDTHLHLGKELEAEGRLPEAEYHYLEAQEWKATVNMYRSNGLWEEAYRVAKAHGGANAHKHVAYLWAKSLGGEAAVRLLNKLGLLEAAIDHAADNCSFEFAFELSRLALKHKTPEIHLRYAMYLEDEGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVGQARGALEEKDFQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYMPGQLEALQEEYEREATKKGARGMEGLVEQARHWEQAGEYSHAVDCYLKVRDSGSSSLVEKCWMKAAELSIKFLPPQRSLEVVRAVGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRVAKELDPRYEDYVDQHYKEFLKNQGKVDSLVGVDVVAALDLYVEQGQWDKCIDTATKQNFNIYKRIFTDMVSSPGTNSAEAYHNWADLRDVLFNLCENLVKSSEANSPAHEEFETMLLIAHYYATRSAAQSVKQLETVAARLSVSLLRHTQLLPADKAFYEAGVAAKAVGWENMAFIFLNRFLDLTDAIEEGTLDALDHSDFQDTDIPFEVPLPAKQHIPEAQREEVRDWVLTVSMDQRLEQVLPRDERGAYEASLVAASTGVRALPCLITGYPILRNKIEFKRPGKAANKDNWNKFLMAIKTSHSPVCQDVLKFISQWCGGLPSTSFSFQ
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSQANQSEFNSPENGDKKPFFRLKSLNLQVFVMLAAIAIIMLFFTFTTEGAYLSARNISNLLRQTAITGILAVGMVFVIISAEIDLSVGSMMGLLGGIAAIFDVWLGWPLPLTIVVTLALGLVLGAWNGWWVAYRKVPSFIVTLAGMLAFRGILIGITNGTTVSPTSNAMSQIGQSYLPSGIGFGIGAIGLMLFVAWQWRRRNHRIRLGLPVAAPQGDVTRQTITAVIVLGAIYLLNDYRGVPTPVLILTALMLAGVFMATRTAFGRRIYAIGGNIDAARLSGINVERTKLAVFAINGLMVAMAGLILSSRLGAGSPSAGNIAELDAIAACVIGGTSLAGGVGSVAGAVMGAFIMASLDNGMSMLDVPTFWQYIVKGAILLLAVWMDSATKRRV
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSMNLRRLLPQRAKQERPQPESSKKKGFLERKKDYVERAKDYNNKRDTLKKLKLQAAFKNPDEFNYKMISSKLVDGVHSEISKTSLKKEQIIDIKTQDILYLQSKRRADDKKIERLQATLQYMDSGLEPTEQIIYVDDEKEVKNFSATKYFDTVPDAFNGSLSTIPKISKLKEGSLVVNPKTAPTLGQLEAMTATSYKELKERKLRRDQLFKAEMDLSKSKIQLKRGTKSGVTKKVGKKEVVFKQVRSK
The following text describes a protein:
Function:
May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes.
Sequence:
MEPTTDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSLENLALRGCCQEAWVLSGKQQIAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPPDNRSSLGPENLSPAPWSLGDFEQLVTSLTLHDPNIFGPQ
The following text describes a protein:
Function:
Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Photoreceptor outer segment membrane; Single-pass type I membrane protein.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MFLGPWPFSRLLSWFAISSRLSGQHGLTSSKFLRYLCLLALLPLIWWGQALPYKIGVIGPWTCDPFFSKALPEVAAALAIERISRDMSFDRSYSFEYVILNEDCQTSKALTSFISHQQMASGFVGPANPGYCEAASLLGNSWDKGIFSWACVNHELDNKHSYPTFSRTLPSPIRVLVTVMKYFQWAHAGVISSDEDIWVHTANQVSSALRSHGLPVGVVLTSGQDSRSIQKALQQIRQADRIRIIIMCMHSALIGGETQTHFLELAHDLKMTDGTYVFVPYDVLLYSLPYKHSPYQVLRNNQKLREAYDAVLTITVESHEKTFYEAFTEAAAGGEIPEKLDSHQVSPLFGTIYNSIYFIAQAMSNALKENGQASAASLTRHSRNMQFYGFNQLIRTDSNGNGISEYVILDTNGKEWELRGTYTVDMETELLRFRGTPIHFPGGRPTSADAKCWFAQGKICQGGIDPALAMMVCFALLLALLSINGFAYFIRRRINKIQLIKGPNRILLTLEDVTFINPHFGSKRGSRASVSFQIISEVQSGRSPRLSFSSGSLTPATYENSNIAIYQGDWVWLKKFPPGDFGDIKSIKSSASDVFEMMKDLRHENVNPLLGFFYDSGMFAIVSEFCSRRSLEDILTQDDVKLDWMFKSSLLLDLIKGMKYLHHREFIHGRLKSRNCVVDGRFVLKVTDYGFNNILEMLRLSEEEPSEEELLWTAPELLRAPGGIRLGSFAGDVYSFAIIMQEVMVRGAPFCMMDLSAKEVIDRLKMPPPVYRPVVSPEFAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILRTLSEGYEVELRGRTELKGKGTEETFWLVGKKGFTKPLPVPPPVGKDGQVGHGLQPAEIAAFQRRKAERQLVRNKP
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
Sequence:
MQVLALKYRPKHFSELVGQESVAKTLSLALDNQRLANAYLFSGLRGSGKTSSSRIFARALMCEEGPKAVPCDTCIQCQSALNNHHIDIIEMDGASNRGIDDVRNLIEQTRYKPSFGRYKIFIIDEVHMFTTEAFNALLKTLEEPPSHVKFLLATTDALKLPATILSRTQHFRFKKIPENSVISHLKTILEKEQVSYETSALEKLAHSGQGSLRDTITLLEQAINYCDNAITESKVAEMLGAIDRSVLEDFFQSLINQDEARLKERYAILENYETESVLEEMMLFLKAKLLSPDFYSILLIERFFKIIMSSLSLLKEGANASFVLLLLKMKFKEALKFKALDDAILELEQTPFNQNPSISYNAPKQESKNIEKREKIEQIERIEGTEKREKLEKKENAETPQTPMLSAKDRIFHNLFKQVQTLVYERNYELGAVFEKNIRFIDFDSQTKTLTWESLATDKDKELLRERFKIVKSIVDGVFGKGESIKIALKNHSENKSTLEVVKELKFPYSKPKPTTETTAETKEKETKEKEIQENDTKEIQEVQPKQAPTALQEFMANHSELIEEIKSEFEIKSVELL
The following text describes a protein:
Function:
Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.
Subcellular Localization:
Cytoplasm.
Sequence:
MKQRQARISRRSAPVLSAVHQPEEWRRRAWGYALASFLALALLSHLHFVPFACLKSTPFSEIPSLDTVLESRWQAAYRRGVFRTTTERSLPKRTIRNGQLSFSLALNEGRQQKRQTLVTAAAAAADPGDHENALQLTRPFIEADFHFGKVDSNEYLFIVDEVADRVRCGPVADLHQHAVLINPFPLGWLSGLLVPYLLEHRPQVMTRDALTAGFAFAQRLQNPYTRLAFNSLEAGASVNHLHFQFWQFDAPLAVELATRQLYFRFGEELTLHILPDAPVHTLAVEYFRTTATGAIVVVQRIIDLLYQHVLPFNLVFSRYYVNAGISPSRSTVYIVLRQRMHPFPGINIGFPEVSGELICTSSSIYHSVTAHNISQHWRDNVRLSGDRYTEFLGSLKRHLPTLLSETT