lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Bifunctional serine/threonine kinase and phosphorylase involved in the dark/light-mediated regulation of PPDK by catalyzing its phosphorylation/dephosphorylation. Dark/light-induced changes in stromal concentrations of the competing ADP and Pi substrates govern the direction of the reaction. In the dark, phosphorylates the catalytic intermediate of PPDK (PPDK-HisP), inactivating it. Light exposure induces the phosphorolysis reaction that reactivates PPDK. Unlike the kinase function which can utilize either Thr or Ser as target, the phosphorylase function has a strict substrate requirement for threonyl phosphate.
Miscellaneous:
MISCELLANEOUS: The initial 51 amino acids are sufficient to act as a chloroplast transit peptide and the removal of the next 35 amino acids reduces the strength of interaction with PPDK significantly, which suggested that these residues are important for binding RP1 and may not be part of the transit peptide.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MALLSAMKLQGRPPPISSNLNPNSKPAGSDSVSLNASEPGSERKPRKFSSQLNRWNRARTLRSGAKLDSTITNGSNNTTGPMRPIESSSRTDVSTLDSDVSSSSNGVSEADMTAAKSIYIVSDGTGWTAEHAVNAALGQFDYCLVDRGCPVNTHLFSGIEDGEKLMEIIKQAAREGAMVIYTLADPSMAEATMRACKLWKIPSLDILGPITESISSHLGTNPSGLSRGITNSSLNEDYFKRIEAIEFTIKHDDGALPENLEKADIVLVGVSRTGKTPLSTYLAQKGYKVSNVPIVNGVDLPKTLFEIDPRKVFGLMINPLVLQGIREARAKSLGLGSSFKTKYSELGSVKEELELAKKIFAENPTWPVIEVTESAIEETAAVVLRLYDERQSNRAMPRISKSY
The following text describes a protein:
Function:
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
Sequence:
MAISIKSPKEIKALRKAGELTAQALALLEREVRPGVSLLELDKMAEDFIKSSHARPAFKGLYGFPNSVCMSLNEVVIHGIPTDYVLQEGDIIGLDLGVEVDGYYGDSALTLPIGAISPQDEKLLACSKESLMHAINSIRVGMHFKELSQILESTITERGFVPLKGFCGHGIGKKPHEEPEIPNYLEKGVKPNSGPKIKEGMVFCLEPMVCQKQGEPKILADKWSVVSVDGLNTSHHEHTIAIVGNKAVILTER
The following text describes a protein:
Function:
Involved in the lipid remodeling steps of GPI-anchor maturation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MERYQLILYCALLVIAIFHSACGSVGDRLERYQSLLSQCVANCREATIPWSISIFGWDCLDNCKYLSMHQVVDELIEYNQPIPQWHGKWPFVRFLGIQEPASVVFSIGNAMANYFGWKAYRESVHSNYRMYHVVRTYTMVSVNAWLWSTIFHTRDLLWTERMDYFSAGAVIAFGHYLFMFYILTNYGYKWLARLYGGIVLLLYSCHIYYMAFIQFSYSYNMRANVAVGFLTALCWCTWFIKTAKSRPHVWIGFLCAIGTPAVAALELFDFPPFWWTFDAHSLWHAATIPFAYIWFLFLRSDAELEIRRDQGKLE
The following text describes a protein:
Function:
Produces N-formyl-kynurenine through the oxidation of tryptophan.
Sequence:
MPSISPATQLPERFRSWDQLAASLPELLRDQTLRATVDRLAVLPTDVKSLPDKYLQRASTLVSIVSHAYVHADMAGPAPLPVCLSQPWTEITRRLGREKPALSYIDLIVYNWKKRSAAGAEFCVENLELLVPTVDTAEERVFYLTQAEILSRATPLLNSIVDAQIAVLCDDVAALAAVLKRMSDVLSDIGRKSLMQIAPNPTRKSHVDPVVWAKSVAPLAVPLSADVPGPGGTASPLFHLMDNFIGRTSYNAVLGEEAQRIRRNYPQNWRNVISAAAEVDIATFVVNKNHPALRQSWELMKERYCGPMGLLGLHRRKVFAYLPMAFKVGRSATIAGFNGDVAQQEWHRVHEELEKSRQERLAEGKLSEPPIVATSNAPKSDGQTYCISTLVEHSSKDVGFWFAANGRVYDATKYLRFHPGGDKILMNSSGRDVTADLLAITHLQDPTIAEKVEKFAIGKLHVPGFNSDKLRQFYDFAVAMAYKVTDLHTTFGNDLTFLYRQLTSVDPSGVLTEQKRRFAVAAMARLGEQFVPSIATHAEVLADLCGSSTMARFKALRRGYLVSVSLEQGHQMLGLCKSQAVLLLKTLESISASASKLSEGQTHTINHILEQLVKLLEAF
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
Sequence:
MEFWLISVPLDKISCQSVEKLKRVAAKNGQSASSRMHIPELKVGTLDVLLGLSDDLSRLDSFTEGVMRQTSQCLAEVMDEFSGKLLESLLAGGEHRTLQKDPKSPLKSYFQTVQVDLATYVTRFQWDRAKYPTAQPLKTLADIISKQVSQVDTELKSRRASYSHLKASIQSYERKSEGSLQNRLLTNIVKKEDLVLNSEYLTTLIVLVPRTEYVLWQKTYESMSKFVVPRSSRKLAEDAEAGVFTVTLFKSVIAEFKANAKKHKFTVREYNLEEAEKQKQKIGRLALDKKELCRTFVCWLKVNFSETFVAWIHVKVLRTFVESVLRYGLPVSFQAILLQPGKKNVKHLKQQLNSLFKHLDPAAISTKPEMGLDIPDGGAGQQEYYSYICYPIKINLVDPS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVRASAPSQAFLLGEHAVLYGSPALALSVDKRSHVEASPLPEGEIMIESELGVYKEGSSYNEDLVKLAEGVKELFNKYGIRSGVHLRIRSEVPASSGMASSASVAAAISKSIDALFNLGMSESELLDAVYTFERIIHGRASKTGPACAVLGGVIWVEWSDGEMRATSLGHREVPVAIACTGEPSRTKEMVERVSKLREAFPEVHEGIVRTISDLVFKGREALESGDFRTLGSLMNINQGLLYSLGVSSFAIERIIWEARMKGALGAKLSGAGGGGCVVILHEAPEEVASNLTSASISFPARVSRRGVVLEP
The following text describes a protein:
Function:
Copper (Cu) transporter that plays an essential role in promoting translocation of Cu from roots to shoots. Involved in loading Cu to the xylem of the roots and other organs, including panicles.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAASTRALFLSCFHGSGGGGGTSEVSRRLVLRPRYPSMPRRPRSAAVAGEGGEGGGGGGDGDLEAAAVGAEEEEKVAVFEVSGMTCAACAGSVEKAVKRLQGIHDAAVDVLGGRAQVVFYPAFVSEEKIRETIQDVGFEAKLIDEEVKEKNILVCRLHIKGMTCTSCASTVESILQVVPGVQRASVALATEEAEIRYDRRIVTASQLTHAVEETGFEAILITTGDDQSRIDLKVDGTLNERSIMIVKSSVQALPGVEDIKVDPELHKITISYKPDQTGPRDLIEVIESAASGDLTVSIYPEADGRQQHRHGEIKRYRQSFLWSLVFTIPVFLTSMVFMYIPGLKDGLEKKVINMMSIGELLRWILSTPVQFVIGRRFYTGAYKALSHGSSNMDVLIALGTNTAYFYSVYSILRAASSHNYMATDFFETSSMLISFILLGKYLEILAKGKTSEAIAKLMDLAPETATMLIYDHEGNVVGEKEIDSRLIQKNDVIKVVPGGKVASDGFVIWGQSHVNESMITGESRPVAKRKGDTVIGGTVNENGVLHVRATFVGSESALAQIVRLVESAQMAKAPVQKFADQISRVFVPLVIILSLLTWLAWFLAGRLHGYPNSWIPSSMDSFQLALQFGISVMVIACPCALGLATPTAVMVATGVGASQGVLIKGGQALESAQKVDCIVFDKTGTLTIGKPVVVNTRLLKNMVLREFYAYVAAAEVNSEHPLGKAVVEHAKKFHSEESHVWTEARDFISVTGHGVKAKISGRAVMVGNKSFMLTSGIDIPVEALEILTEEEEKAQTAIIVAMDQEVVGIISVSDPIKPNAREVISYLKSMKVESIMVTGDNWGTANAISKEVGIENTVAEAKPEQKAEKVKELQSAGRTVAMVGDGINDSPALVSADVGLAIGAGTDVAIEAADIVLMKSNLEDVITAIDLSRKTFFRIRMNYVWALGYNIIGIPIAAGVLFPSTRFRLPPWVAGAAMAASSVSVVCWSLLLRYYKSPKLGR
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEVVRFVFGIFGNATALFLFLSPLVTFQRIIRKRSTEDFSGVPYTMTLLNCLLSAWYGLPFVSPNNLLVSTINGAGSVIEAVYVLIFLVFAPKKERARVAALFTFVLSVFAVIALVSLLALRGQRRKIFCGFAAAIFSICMYASPLSIMVRSLDHLPLLGLHEVPVRDGSIWASQSNLRAEIGDQDQKRGVHAVSAVLVRVLVRDIMVRLWLTGWGSIRHGAEWVWERAGSHPADPVCNLQESHHHRRGLGDERPGTQAAGG
The following text describes a protein:
Function:
Ureohydrolase involved in the biosynthesis of spermidine via the carboxyaminopropylagmatine (CAPA) pathway. Catalyzes the conversion of aminopropylagmatine (APA) to spermidine and urea. Is highly specific to APA and incapable of releasing measurable urea from CAPA, agmatine, arginine, guanidine, guanidinobutyrate and guanidinopropionate.
Sequence:
MHSPNKFTSGPKQFLESEAITSYADAAVVVVPIPYEATTSYRKGCEHGPEAVLEASDQLEAYDEELGTSPCHDLGIYTCAPLADSNKHPALAGDAMVTEVCDGIAPFVEDGKFVVAIGGEHAITTGVVRAMQRGTSEPFTVVQIDAHGDMRDKFEGSCHNHACVMRRVLELGLPTLPIAIRAICQEEADLIREKNIPVFWAREMADNPNWINEAIASITTQKVFLTIDMDGFDPGFMPGVGTPEPGGLGWYEGLNFFRRLFQTKQVIGCDLMELAPVRGSVVSEFSTAKLAYKLMGYWGESQRKKL
The following text describes a protein:
Function:
Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents (By similarity). Required for meiotic progression, hence for fertility.
Subcellular Localization:
Nucleus.
Sequence:
MAVALPEVVEELLSEMAAAVRDSARIPDELLLSLEFVFGSSAIQALDLVDRESVTLISSPSGRRVYQVLGSSGKTYTCLASCHYCSCPAFSFSVLRKSDSLLCKHLLAIYLSQLLRNCQQLHVSDKQLTDLLMEDTRRIKGAAGTWTSKTEA
The following text describes a protein:
Function:
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum where it forms a ring structure.
Sequence:
MNTATRVIVAQNVRTRNRTFQITKQGVVIVALVIALLCSAFGVVYFKDLNRRLFIQYQTLQREKAEELIQWGKLLLEQTTWSTQSRVQRIAEQQLGMQLPSAKEVILVNADAMIE
The following text describes a protein:
Function:
Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
Sequence:
HEFFVDMTCEGCSGAVTRVLNKLGVKFDIDLPNKKVFIESEQSVEVLIETLKKTGKTVTYIGPK
The following text describes a protein:
Function:
Formylates methionyl-tRNA in mitochondria and the cytoplasm. Responsible for the formylation of the 8 N-terminally formylated (Nt-formylated) mitochondrial matrix proteins that are encoded by mitochondrial DNA. Nt-formylated proteins in the cytoplasm are strongly up-regulated in stationary phase or upon starvation for specific amino acids (His or Lys) and are targeted for degradation by a PSH1 E3 ubiquitin ligase-mediated fMet/N-end rule pathway. Increased Nt-formylation of cytosolic proteins appears to be important for adaptation to these stresses. Stationary phase-degraded Nt-formylated proteins include histone H3-like centromeric protein CSE4, Mediator complex subunit 3 (PGD1) and small ribosomal subunit protein uS8-A (RPS22A).
Miscellaneous:
MISCELLANEOUS: Formylation of the initiator Met-tRNA is not essential for mitochondrial protein synthesis in S.cerevisiae; MISCELLANEOUS: Present with 1070 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Mitochondrion matrix. Cytoplasm. Note=In exponentially growing cells, more than 97% of FMT1 is present in mitochondria. In stationary phase, about 35% of FMT1 becomes localized to the cytosol in a GCN2-dependent manner.
Sequence:
MVKMRRITPTRLLFTCRYISNNASPPVQPLNVLFFGSDTFSNFSLQALNELRQNNGSCGIVDNIQVVTRSPKWCGRQKSILKYPPIFDMAEKLQLPRPITCDTKQEMLALSKLTPSRQGNPENDGSGAPFNAIIAVSFGKLIPGDLIRAVPLALNVHPSLLPRHKGSAPIQRALLEGDTYTGVTIQTLHPDRFDHGAIVAQTEPLAIATMLSKGRVNDSTADFNSEGLPRRTAILMDQLGALGAQLLGQTLRERLYLPQNRVQAPTAYKPSYAHRITTEDKRIHWARDSAAELLNKLETLGPLHAFKEATAARKDAQNSVLKRILFHECKVMRDARLDNGSKPGMFKYDDIKDCILVTCRGNLLLCVSRLQFEGFAVERAGQFMARLRKRCGALSEKLVFL
The following text describes a protein:
Function:
Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to exon inclusion. Unphosphorylated form.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation.
Sequence:
MPAGLTEPAGAAPPAAVSASGTVTMAPAGALPVRVESTPVALGAVTKAPVSVCVEPTASQPLRSPVGTLVTKVAPVSAPPKVSSGPRLPAPQIVAVKAPNTTTIQFPANLQLPPGTVLIKSNSGPLMLVSPQQTVTRAETTSNITSRPAVPANPQTVKICTVPNSSSQLIKKVAVTPVKKLAQIGTTVVTTVPKPSSVQSVAVPTSVVTVTPGKPLNTVTTLKPSSLGASSTPSNEPNLKAENSAAVQINLSPTMLENVKKCKNFLAMLIKLACSGSQSPEMGQNVKKLVEQLLDAKIEAEEFTRKLYVELKSSPQPHLVPFLKKSVVALRQLLPNSQSFIQQCVQQTSSDMVIATCTTTVTTSPVVTTTVSSSQSEKSIIVSGATAPRTVSVQTLNPLAGPVGAKAGVVTLHSVGPTAATGGTTAGTGLLQTSKPLVTSVANTVTTVSLQPEKPVVSGTAVTLSLPAVTFGETSGAAICLPSVKPVVSSAGTTSDKPVIGTPVQIKLAQPGPVLSQPAGIPQAVQVKQLVVQQPSGGNEKQVTTISHSSTLTIQKCGQKTMPVNTIIPTSQFPPASILKQITLPGNKILSLQASPTQKNRIKENVTSCFRDEDDINDVTSMAGVNLNEENACILATNSELVGTLIQSCKDEPFLFIGALQKRILDIGKKHDITELNSDAVNLISQATQERLRGLLEKLTAIAQHRMTTYKASENYILCSDTRSQLKFLEKLDQLEKQRKDLEEREMLLKAAKSRSNKEDPEQLRLKQKAKELQQLELAQIQHRDANLTALAAIGPRKKRPLESGIEGLKDNLLASGTSSLTATKQLHRPRITRICLRDLIFCMEQEREMKYSRALYLALLK
The following text describes a protein:
Function:
Cell-counting factor that limits the maximum size of the multicellular structure. Does not possess acid phosphatase activity. Cells with decreased levels of this protein form large groups while cells overexpressing this protein form small groups.
Subcellular Localization:
Secreted.
Sequence:
MIKKSALITLFLVSLILGVSLSQKPFYCQAPEPTPSLNTDGLTLKMVQILTRHGDRTPLYSTLKPTMNTWDCNLGWLMVSSLNNVPGAATDVDRLFRKVYMPNREYFPGNCSDGQLTSLGFQQHLQLGQSLRQLYVDKYELLPSELSVDAASTIWVRSTDVPRTIQSVQGHLTALFPPTTVTSGSGIPIININTMDNYYENMTPNPTLCPELAVLIANTTTTPEWGEFITNTTQLKEDVMETLGISVFPGWSSLMDLFFATQCHDFPLPEGVTQDMVTQVYEAAYWQYQYQLSFPMIARLGMSTFLEEVVDNIRAFVNGTSSVKYIVFSGHDDSVGPFTNLFGLMKEWPPYASHVELELWSDEKDNYFLQFKFNGQSYTLNGCEDVMCPIDSFFETAYSILVPNYADACSNSTMTF
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).
Subcellular Localization:
Cytoplasm.
Sequence:
MRTQVIKPRIREILSKELPPELVSLLPKHWVQIGDVLILPLRPELEPYKRRIAEVYAQVIGAKAVLRKGHIHGETRKPDYELLYGNDTITVHVENGVKYKLDVARIMFSPANVKERVRMAEVAKPGELVVDMFAGIGHLSLPMTVHKGARVIAIEKDPYTFRFLVENIWLNGVQDLMTPYNMDNRDFPAENIADRILMGYVVTTHEFIPKALSIAKDEAIIHYHNTVPERLRPEEPFATFKRIAREHGYEAEKLKELVIKRYAPGVWHVVVDIGVYKR
The following text describes a protein:
Function:
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Sequence:
MTTQTPPPSADPASQKIFTIGTRKSKLALLQTDLVLAALKERFPDYTFKIHSRETAGDQNTTIALRDFTTKNLWTQELEDLLEAGSVDLIVHSLKDVPTLLPTSCTLGPMMKREDSRDGLVIKKGLPNMSLAEMPAGSVVGTSSIRRTAQLARKYPHLKVMDVRGNIGTRLAKLDAEDSPYTCLILAAAGLLRLGLGDRIYQYLDSRNAGMLYAVGQGALGIEIRKGDKAMEDILNTIGHKETTFACLAERSLLRTLEGGCSAPLGVETEWIQDTNGSSKLRMRSVVVSVDGSEHAEVEIDGTVDSPQSAEEFGVTVAKALVNEGAGKILSEIQQNRQLKVPVSEST
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MYQQLFEIYQHLISFLSQQRVMADRLTQLQDAIDELALQFVASLVWVNKHHDYQTLSPTDIVRKDTKKDESGEALPNEDGLEPLPADKFKEGQVELARDLIVKEQQIEVLITALPGLENSEKEQQQTIQRLERELKEEEERRKEALKEKEAVLARLEGVIRSIKRP
The following text describes a protein:
Function:
Bifunctional enzyme involved in flavonoid metabolism.
Sequence:
MKRVCVTGAGGYIASWVVKLLLSKGYMVHGTVRDPCDEKKNGHLKKLENAEERLKLFKADVLEYENLCAAFAGCIGVLHVASPVPGGPVSNPQVELLDPAILGTKNVLNACLNAKVEKVVVVSSASALLGNPKWPTDLEMDESCWTDIEYAKSIEHWYAMSKTVAEVEALEYGKRDDLSVVTICPSFVIGPMLQSTINATSLILLSYMKEEGRTGGDTIENAERPYVDVRDLSEAILLLYENPESNGRYICSPYSLRTRDFVAMMENMFPGHTYPKIFTEKSGRTLLSSKKLVNLGWSYRPLEETIVDTVNNYEELGFLEKGKPYPATIKF
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MGEAMMSYLLTFGSIYVHLPGKNYVQLCGVPLCDVPVLSRTEDVRKKRKTRPWPDAPKSQKKPNSRESISKKVSIRQILFTMNPTNSSPNYSVGFDKNYPLSISRPRPLHKRSLYVLCLMFPKQIPSSHESSGSIKGKTDSQHSSFSDFVIPKRLNSAYSMIRQLLKRYDKTSYQELYQYYCPFPKDAIAKREASTSITDFSVGSHQVYAFVKAVLKRVIPKNFWGSTANFQHLLKAVKFFINLRRYDVLNLDHVLLDIKIKDIRWLELPSTKGCRMSLTDFNKRKEIFAEFVHWLFSSFVMNLLQTSFYATESSGQRNKIYFFRRDVFHDLSEPFCHDIRNRLFEPVDANELDEKLHVASIRLLPKRNTFRLIVNLSRKLQLKESFTKETTFRSSSTNTMLLPLATILGWKTKLLSKKEAVYTTLADVYTELINYKARLSRVDMMNCKKYFVKVDIRNCYDCIDQKKLLRIVRTLFDEDEFLIRKYAIVRACYENFVKKYALSACTYADYLNFFQFAMQFKGRRDCQVFIDNVDSQTRTTDELMLLLKQHITQHTVSFGNGCYRQTQGIPQGSKISNTLCFFYTRDLVRKRLRFVNKGNSVLLRVVDDFLFITTRKRDAKRFLSLMVKGFPDYNFYVNEDKTMVNFDPGPKYLNKIKIASDELLFCGFRVNLRDLSIGRELYIQSSAHRRIITVEHASCIWQVLCKRLMGTVFSSLHPIFLNASHNSPSAIRYNVYTVAHNTAFRLRQYIHEYKLLPINVHDIVSKVWFVLSTRFRVYSLGVVNSSKPESLQFTSAEMKWLIIQGALDALRPVKQLAAFTLSLSREQKRLEKKIPVMYLRQCVSSRRFRAINLR
The following text describes a protein:
Function:
Plays a role with ILK in promoting the cell adhesion and spreading of leukocytes.
Subcellular Localization:
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Constituent of focal adhesions.
Sequence:
MEPEFLYDLLQLPKGVEPPAEEELSKGGKKKYLPPTSRKDPKFEELQKVLMEWINATLLPEHIVVRSLEEDMFDGLILHHLFQRLAALKLEAEDIALTATSQKHKLTVVLEAVNRSLQLEEWQAKWSVESIFNKDLLSTLHLLVALAKRFQPDLSLPTNVQVEVITIESTKSGLKSEKLVEQLTEYSTDKDEPPKDVFDELFKLAPEKVNAVKEAIVNFVNQKLDRLGLSVQNLDTQFADGVILLLLIGQLEGFFLHLKEFYLTPNSPAEMLHNVTLALELLKDEGLLSCPVSPEDIVNKDAKSTLRVLYGLFCKHTQKAHRDRTPHGAPN
The following text describes a protein:
Function:
Plays a role in the regulation of phosphate uptake.
Subcellular Localization:
Cytoplasm.
Sequence:
MVVRKIFTEQLNDLHQHLMEMGMLANEAIFKAVKSLVHRDTELAKQVVAEDKAINNMELSLEQRSFELIALQQPVGMDLRKIVTVLKTSSDLERIGDHAVSIAKTAILIGESKVLKPIPEIPEMGEIVKSMLQDVLKAYLAEDEGAAREIAERDNEVDKLHKIVYQKCIHFMQEEPEHIEDVSQLLLVSQYIERIGDYVTNVCEWIVYLKSGEIEDLNR
The following text describes a protein:
Function:
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MEHEVGMDADISDFTLGADGYVRIWSTEAIYNTGNPEYANKPKQLASMSNHSGTIHTVRFSPNGKYLASGADDKIVCIYTLDANPPSHASTFGSNEAPPVENWRTIRRLIGHDNDVQDLGWSYDSSILVSVGLDSKVVVWSGHTFEKLKTLSIHQSHVKGITFDPANKYFATASDDRTVRIFRFTSPSPNSTAHDQMNNFVLEHTISAPFQNSPLTAYFRRCSWSPDGMHIAAANAVNGPVSSVAIINRGSWDGDINLIGHEAPVEVCAFSPRLYSSQPVSKSAVDNQNHAMQNVTVIACAGGDKSLSIWITSNPRPIVVAQEMAAKSISDLAWSPDGKCLFATALDGTILAVRFEDGELGYPMAMEENEKSLTKFGTNRRGAGIAETTDGLLLEEKSKAGEIKDVEGRMGALMGDGHATAESMVNGKTAPLPSNGATPARGPSPAADTQKAQPNGTAATPAAPEPEKPDPYQAKLERLKQRPTYTKDGKKRIAPLLVSGAGAAESSLPQARLMASVSSQVKADVPQSIVDLSKPFDGLPKGGLSALLFGNKRKLAQLEGDEDGHVEKRVALASQNGATPILANTPDGLLPAQPQPAPTGQQPTPEFIRPAVTNPCMAISQLRLAVPKVRSQIVRAIDSNGRPTEPPSATGEPGKSRADVVFEARNPSPASLTGRAVDREPVRLTLFRGEQPLWQDFLPRTVLLVTGNQSMWSAACEDGSVYIWSPAGRRLVSALVLEAQPVILECNGPWILCISAVGMCYVWNVKHLSSPHPPISLQPVLDAAIHTLGAHPSAAPAITNARINSEGRVVVALSNGEGYSYSPSMYTWQRVSEAWWAVGSQYWNSTEAPVGNLQSAGPQQDKETTAAVSAGIIPFLERNTTNETLLRGRAYFLQRLIKVLLSREGYESFESSVSIAHMENRLAAALSLGAKEEFRLYLSMYAKRLGAEGLKMKVEELLKGLIGGLFEEEDETGTGRRLQANEKEDRNWQESSDTLCGWPREVLLKEVILALGKHRDLQRVTVPYAKLLGVVDNESEDNDAMET
The following text describes a protein:
Function:
As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. wac is dispensable for somatic mitosis and for assembly of spindle microtubules in oocytes during female meiosis but is required during female meiosis for chromosome alignment and segregation. It is required for microtubule assembly near spindle poles in oocytes. It is also required for acentrosomal microtubule nucleation and meiotic spindle formation during male meiosis. wac binds to microtubules in vitro.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Enriched at spindle poles during meiosis in oocytes.
Sequence:
MQNLKIQEEVNSLMRLGQHFDDQLKLASVELGDFSDDDLALLDKCAQYYSLLHIHDINLNYLRDFYCAKKRECIENRQTTVQQRVELQRILSSIEEATRDVVMLERFNAAAEERLIPDIVVMQRNAQQLATKQALLDRQKTLKIPKDFSIESVIEKVDSLEQR
The following text describes a protein:
Function:
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
Sequence:
MNSFSTLSILQIILFPILYVFSFLYRALFLLDQKFTKKKKLPGAFVISVGNLSMGGTGKTPFSIFLAKLIHKKFPDQKIIILSRGYNAKGSLRGHRVGPHSTPMEAGDEPLLLKKHLPFAEVWIGKDRYSSYIHFREELRMRENSIVILDDGFQHHVLERDVDLVLLDSSKISKERFLIPAGNLREPISSLIRADQIIFSKYESSIEKIVQNIQNKFSKEILRFSLEPDKLLSPNLQSDSPKILSGKKVYAFTGIGNPEVFFSMIRKFEPLKLETRAFRDHHSYTIEDENVLNLIAKNFDFLVCTEKDLVKISNPPNQLRILLLKSKLDKEEFLISFLQKKISLKTF
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEIKEEPCRIKEEVTEKLIGPVEVEELKQPHHFKNEDANAAEQDFTQKQVQTAEAKELFACSECGKSYTYKSSLKKHMSAHSGEKLFACTQCGKSYMYKSDLNRHFKVHNGDRPYICSECGSSFIYKGHLKEHMKIHSGEKPFTCAQCGNSFMYNKDLNAHMKIHSGEDMFECTHCGKKFTRKGHLNVHLRVHTEDKPFACAECGKSFKYKSVLNNHLHTHAEVKSFSCDQCGKSFVCASNLRTHLKVHTGVKPYICAFCGKKFLHMSYLKLHQHTHTGVKPHACSVCGKSFGLLSNLKKHQRIHTGEKPYMCSHCGKSFSCSSAVKAHERIHTGEKPYPCSSCGRRFALFHNMRSHEKKHRLKLSL
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MKPSTAYLALYNAAQACGWAAILVVLVIGVTQRETPEQLYDRAAPLTKLVQGAAILDTLHAAVGLVPSSPAMTLMFWVGRGNALFAITEPIAALHASWWAVLMLGAWAAAEVIRYPWYAAITLGACPGWLTWLRYTMFIPLFPLGTLAEMALMWTALPELQSRRLYSLGLPNPYNWAFDYHRFIQIVLLLYPLLWWQLYSSLLRARAKKLGGSKGGSSKGGSGEGSRPPAADILRQETRSKLLKTQ