lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload.
Miscellaneous:
MISCELLANEOUS: [Isoform 5]: May arise by a -1 programmed ribosomal frameshift at codon 233. A nucleotide 'slippery sequence' followed by an mRNA pseudoknot are found downstream of the frameshift site and direct frameshifting of a gene fragment with about 10% efficiency.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome. Note=Predominantly found in the trans-Golgi network (TGN). Localized in the trans-Golgi network under low copper conditions, redistributes to cytoplasmic vesicles when cells are exposed to elevated copper levels, and then recycles back to the trans-Golgi network when copper is removed; [Isoform 1]: Golgi apparatus membrane; Multi-pass membrane protein; [Isoform 2]: Cytoplasm; [WND/140 kDa]: Mitochondrion.
Domain:
Each HMA domain can bind a copper ion, they are tightly packed and closely interact with each other. Wild-type ATP7B can usually be loaded with an average 5.5 copper atoms per molecule.
Sequence:
MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGLDGLGPSSQVATSTVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMGFEASIAEGKAASWPSRSLPAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSRHSAAADDDGDKWSLLLNGRDEEQYI
The following text describes a protein:
Function:
Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates, and participates in the detoxification of a plethora of hydrazine and arylamine drugs.
Subcellular Localization:
Cytoplasm.
Sequence:
MDIEAYFERIGYKNSRNKLDLETLTDILEHQIRAVPFENLNMHCGEAMELGLETIFDHIVRRNRGGWCLQVNQLLYWALTTIGFQTTMLGGYVYIPAANKYSTGMIHLLLQVTIDGRNYIADAGFGSSSQMWQPLELISGKDQPQMPSIFRLTEQKGIWYLDQIRREQYIPNTEFLNSDLLPKTTHQKVYSFTLEPRKIEDFESMNTYLQTSPTSAFTTTSFCSLQTPEGVHCLVGFTLTYRIFNYKDNTDLIEFKTLIEEEVEEVLKNIFKISLGRKLVPKPGNGSFTI
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mL54 may have a meiosis-specific role as it accumulates during the middle stage of sporulation.
Subcellular Localization:
Mitochondrion.
Sequence:
MPFIESMAPLSRAITRGISQFSCYSNTLVLRSSRNSSSSLVKRSYVSSRVSPKKPQHNSDATSSAQKVANKTHTSSVLPGTILKGLCIKAGGVDPVAREDHEYPEWLWSLLDEPAPNSKTARSHARKSAIRAANFLTKK
The following text describes a protein:
Function:
Small polypeptide acting as a regulatory molecule which coordinates cellular responses required for differentiation, growth and development, probably by restricting polar cell proliferation in lateral organs and coordinating socket cell recruitment and differentiation at trichome sites.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MAGTVVLRCCTSVTKVRTWKRCSKQIKEQRARLYIIWKCAVFLLSSHD
The following text describes a protein:
Function:
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU.
Sequence:
MALLQISEPGLSAAPHQRRLAAGIDLGTTNSLVATVRSGQAETLPDHEGRHLLPSVVHYQQQGHTVGYAARDNAAQDTANTISSVKRMMGRSLADIQTRYPHLPYRFKASVNGLPMIDTAAGLLNPVRVSADILKALAARASESLSGELDGVVITVPAYFDDAQRQGTKDAARLAGLHVLRLLNEPTAAAIAYGLDSGKEGVIAVYDLGGGTFDISILRLSRGVFEVLATGGDSALGGDDFDHLLADYIREQAGIADRSDNRVQRELLDAAIAAKIALSDADTVRVNVAGWQGEITREQFNDLISALVKRTLLACRRALKDAGVEPQDVLEVVMVGGSTRVPLVRERVGEFFGRTPLTAIDPDKVVAIGAAIQADILVGNKPDSEMLLLDVIPLSLGLETMGGLVEKVIPRNTTIPVARAQDFTTFKDGQTAMSIHVMQGERELVQDCRSLARFALRGIPPLPAGGAHIRVTFQVDADGLLSVTAMEKSTGVEASIQVKPSYGLTDGEIASMIKDSMSFAEQDVKARMLAEQKVEAARVLESLTGALTADAALLSAAERQCIDDAAAHLSAVAQGDDVDAIEQAIKNVDKQTQEFAARRMDQSVRRALKGHSVDEV
The following text describes a protein:
Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.
Subcellular Localization:
Nucleus.
Sequence:
MALKKNTHNKSTKRVTKHPSLKTLTHKQIHTTIFVKSTTPYVSALKRINKFLDSVHKQGSSYVAVLGMGKAVEKTLALGCHFQDQKNKKIEVYTKTIEVLDEVITEGQADIDMESDVEDDDKETQLKKRAVSGVELRIYV
The following text describes a protein:
Function:
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA.
Subcellular Localization:
Mitochondrion. Cytoplasm.
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD
The following text describes a protein:
Function:
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MAPCVSCFLLAVLISAGCKAIPSSDPKCTEKEGNRTYNCENLGLREIPDTLPNTTEVLEFSFNFLPTIQNTTFSRLINLIFLDLTRCQINWVHEDTFQSHHQLNTIVLTGNPLIFMAETSLTGPKFLKHLFLTQTGISNLEFIPVHNLENLESLHLGSNHISSINLPENFPTQNLKVLDFQNNAIHYISRKDTNSLEQATNLSLNFNGNDIKGIEPGAFSSKIFQSLKFGGSLNLFIIFKGLQNSTLQSLWLGTFEDTDDQYLTSATFEGLCDMSVESINLQKHRFSDLSSSTFRCFTRVQELDLTAAHLNGLPSGIEGMNSLKKLVLNANSFDQLCQINAASFPSLRDLYIKGNMRKLDLGTRCLEKLENLQKLDLSHSDIEASDCCNLQLKNLRHLQYLNLSYNEPLGLEDQAFKECPQLELLDVAFTHLHVKAPHSPFQNLHLLRVLNLSHCLLDTSNQHLLAGLQDLRHLNLQGNSFQDGSISKTNLLQMVGSLEILILSSCNLLSIDQQAFHGLRNVNHLDLSHNSLTGDSMDALSHLKGLYLNMASNNIRIIPPHLLPALSQQSIINLSHNPLDCTCSNIHFITWYKENLHKLEDSEETTCANPPSLRGVKLSDVKLHCGITGVGIFFIVVFVFLLILLLIFSVKFILRWKYQHI
The following text describes a protein:
Function:
Mitochondrial inner membrane-associated mitoribosome receptor that spatially aligns the mitoribosome exit tunnel with the membrane insertion machinery and allows cotranslational protein membrane insertion.
Miscellaneous:
MISCELLANEOUS: Present with 2720 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Localizes near the mitoribosome exit tunnel.
Sequence:
MSVLRSTCLFFPPRSLLISFNKRRLFSTSRLILNKESETTKKKDKSKQQDFNPRHLGVAAEIFIPSAYKNLPNVFAHPLIVANALIRRLYTFGLNSVQVALFRFQSGIKPSFLLWKNKAIETYINVNTSFAHKNLSDIKGLVSLWVQEALEARSRQLPGNATLDWQLIKFNAVPKLVSVQPIMIPGMPLEHLQLVYKFDTKQRLIKVNQQTKKTETLDRDVVDYIAFLCDATTNDMILMGSLFESKPNDKLPKSYEDDAKVAIHRMKVNGDIYRLPPS
The following text describes a protein:
Function:
Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors (By similarity). These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense (By similarity); Plays a key role in defense against host by cleaving histatin-5 (Hst 5), a peptide from human saliva that carries out fungicidal activity. The cleavage rate decreases in an order of SAP2 > SAP9 > SAP3 > SAP7 > SAP4 > SAP1 > SAP8. The cleavage of Hst 5 by SAP7 results mainly in the appearance of the long DSHAKRHHGYKRKFHEKHHSH peptide which is then slowly proeeded to DSHAKRHHGYKR.
Subcellular Localization:
Secreted.
Sequence:
MQRVLELLLLSSTALAVIGDGFIALPVHKLQAGEGSAHFPNRLPIFDVVNGVAKSVEDDVNQIIQPIFGNGIFSGGSIQGTHSGNGHSVKYEVSLPSSSSQKGSNGPSSTDNKDTDPSKTGFSLDDLMNSIPTDFWNLIGLNKAPTSSDNGSKDADFTPSAVSQVEQPTSKSVESTAPGPASSASSSSSSEAASSSQPSEDSQPSSSANKKTGAFFLSLDNTQTLYTATLKVGSPAQEVQVMIDTGSSDLWFISSGNSQCKVNGGSIDCDKYGVFDKSKSSTWHDNKTDYSISYYDGDKASGTMGQDNITFADGFSIENANFAVIDNTTSSIGVFGVGYPELEAVKSKYTNLPFAMKEQNLIAKVAYSLYLDSRDAVQGYILFGGIDHAKYTGDLKAFDIVQSNDKYVYSQIPLTSVASSLNNYTNAYGLPAGSNHPKVGAVIYNGTDSFNGGVDLKDTPTLLDTGTTYSYLSKDQVESIVGLYGNVTYNDAGKAYEVPCWVGNPGNYLEFNFKNEQYIKVPTSEFVISVGTYASGAELCVFGILPGTHSILGDNFMRSVYAVFDLEDHVISIAQAAYNDNHAVVPIE
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAGAGEGGDELKLLGNLTSPFVLRVKLALSFKGLSYEYIAEDLQNKSNLLLSSNPVHKKVPVLIHKGEPICESQVIVQYIDEAFQGTDGPSLLPADPYERAVARFWAAYVFDKLLPAWLQSFMGKTDEEKAEGLKQTFAAVDQLEAAFKECSKGKPFFGGDSVGHMDVALGSLVPWGVYAGEKLYGFRLFDAARSPLLNAWLERFAALDAAKAVLPDADRLVDYAKMKRAEAEAAAAAAASSNN
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MSPRVNPQQTKTSLLTSVGVRSEVLSKPARFITSTACPTVENSAKQAKLNQGIPSLTWDSTLESYATDWAATRTAAGDDCALIHSGGPYGENIFWSTGPSPPADAVQSWVSEEAYYDYASNSCSAPEGESCGHYTQVVWRDTAALGCGSATCPSGALFVVCSYDPAETLTVSCLTRPPLRIAAAVERLRVSSLLKWWTYSNQSTYITCTSVDEYRSQIREGAGMRISWEGTPSLPGVRMTESAVGIVFLNRGYCECFYPGRVLTYIL
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MARDFGTEEMEREDGVELSLGLSIGGSFRRSQEKVGFNGACNSDLKITETKERESVVHGGERETGVIPNGFSVFNAFENREGGSELMEQQRKREMHALRRQEARKKREEKQQKKGFPKVSNGVSLEDRSTLEAQELACRVKDRQVRERELGRSERKSVLQKEEEEEGRERKCGSEKQNLTLNINQQENNPCGYAPPAGFPVYPFQFIPNSHHHHVQYLPFANGFSFPYVMPCWTPVAPGSGNPNHNPNSQDGGSSNGSGTVFQPIPCRSIPHPNPNSSSEESKKSGKDGVKQELSSIASQGSGSAISDYESGSPQGGSSSDMRSNSSHSHSDRGPNIRSLSNQIPANGSSHPSAISEPSTSSHKVAEEAPDKSSAHSSPGKAQSLKPEPDLGSITQPQIPESKPIEPISSSAQGTLKTRPEPNLGLVIQTKQCERINGQEKKVALPHMPCVSATGDGPDGKTINGFLYRYTKGEISIVCVCHGSFLSPAEFVRHAGVTDVSQPLKHIIMAPTTFG
The following text describes a protein:
Function:
Transcription factor that controls hypaxial muscle development by down-regulating myod1 and cdkn1b/p27, thereby allowing myoblasts to proliferate before the onset of terminal differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MTSKDEAKSSSVEERRRHALDLLPPPANSNKPLTPFSIEDILNKPSVRRSYTICGTAHLLSTAEKPPAAGLPLSSRALLSQTSPLCALEELASKTFKGLEVSVLQAAEGRDGMTIFGQRQTPKKRRKSRTAFTNHQIYELEKRFLYQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKLKRDLEEMKADVESVKKMSPSTVEAVLTISELEEETNSVRDDSRSRSPQLGLSGHMPLSPSSPLTEQHTSKECSEDEEDVEIDVDD
The following text describes a protein:
Function:
Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia.
Subcellular Localization:
Nucleus.
Sequence:
MHCHAELRLSSPGQLKAARRRYKTFMIDEILSKETCDYFEKLSLYSVCPSLVVRPKPLHSCTGSPSLRAYPLLSVITRQPTVISHLVPTGSGLTPVLTRHPVAAAEAAAAAAETPGGEALASSESETEQPTPRQKKPRRSRTIFTELQLMGLEKKFQKQKYLSTPDRLDLAQSLGLTQLQVKTWYQNRRMKWKKMVLKGGQEAPTKPKGRPKKNSIPTSEEIEAEEKMNSQAQSQELLESSERQEEPCDTQEPKACLVPLEVAEPIHQPQELSEASSEPPPLS
The following text describes a protein:
Function:
Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation (By similarity).
Sequence:
MASISDDGMALSGYLKKLKTMKKKFFVLYEETSNSSARLEYYDTEKKFLQRAEPKRVIYLKNCFNINRRLDTKQRFVIVLSSRDGGFGIVLESENDLRKWLDKLLVLQRNIANTNGTAYSPYDQVWQVVIQKKGISEKVGITGTYHCCLTSKSLTFVCIGPDKTPNGEERVASIEILLTTIRRCGHASPQCIFYVELGRQSVLGSGDLWMETDNAAVATNMHNTILSAMSAKTESNTNLINVYQNRPDLSHEPMRKRSSSANEASKPINVNVIQNSQNSLDLRSCSSPHNYGFGRERCDSLPTRNGTLSESSNQTYFGSNHGLRSNTISGIRPHSSNKHSNSPTFTMPLRCSASEESSISIEESDDNGSFSHYRLNTRSSETAIPEENIDDFASAEFSKVSEQNESDENYIPMTPINPTDAIHEKEKVDMQRLEDGSLHFDFPEHASEKLARDFDLDSDNQCGRPIRAYSIGNKVEHLKFNKRLGHLNDTGQNPNRVRAYSVGSKSKIPRCDLQRVVLVEDNKHEFAANRSQSSITKEGTSYSTSSNRQKKSTSAPLLSLKNHINSDRMSDLMEIDFSQATNLEKQKFIKNNEIPKYIENVFPKTPRTDSSSLTLHATSQKDIFNGTKLNNTVNASEEGYLEMKPVGNAYTPSSNCLPIKVEKLKISDYTAPLTTAAPVHDLNKISAYNISAEKWKEQSLCEEKKSNSPLNETPCSLKPTDVESNSHDEHSTNNMECEVSVQCDKQNNLDDKVAENNNLDIGGHEEKKLVHSISSEDYTQIKDKSNDFTKFNEAGYKILQIKSDSSLISLKLYQKGIHKDNLERSHRLTESVNTIPDNATASSSVTKFNINTKAADSRSTDPSTPQNILQIKDLNFPSRSSSRISQPELHYASLDLPHCSGQNPAKYLKRGSRESPPVSACPGDGNTYAKIDFDQSDSSSSSSNIFNT
The following text describes a protein:
Function:
Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MATFSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSCRWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRNKKRKARGTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSKPLNVELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLARILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
The following text describes a protein:
Function:
Cell surface metalloreductase. May be involved in copper homeostasis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIEERDLVLSNGIHCIADIHSELYARLKKESQAATPWVYQKQYGKFVTYFVAVIIFLSLIKKLAFMYYDSSEEFLPEKKNSPTTPSVFLARIMTKLVAFNRYICYRKFPTLIFSYLGIPTSVGTFLVVMATTLYTLLYCFVPHPFYRPCAGFGSPPLSVRAGIMAISLVPFVFSLSGKINVIGWLVGLSYEKINIYHQWASILCLFFSWVHVIPFLRQARHEGGYERMHQRWKASDMWRSGVPPILFLNLLWLSSLPIARRHFYEIFLQLHWILAVGFYISLFYHVYPELNSHMYLVATIVVWFAQLFYRLAVKGYLRPGRSFMASTIANVSIVGEGCVELIVKDVEMAYSPGQHIFVRTIDKGIISNHPFSIFPSAKYPGGIKMLIRAQKGFSKRLYESNDDMKKILIDGPYGGIERDIRSFTNVYLICSGSGISTCLPFLQKYGPILHKTNLEVITLDWVVRHREDISWIRDEMCTLSNNLRQLFLDGKIVVRIYVCSDSTVPGIIKTFPQTIDTASDQSDLAKREKDTEFGQDDTESNSTFDKSNNEYKGLITIIPSKPDLNQVINDYQIGFRNCFICSGSDSLRYTVGNSVAGLQAKVFSNKNVEECYLHSESFGY
The following text describes a protein:
Function:
DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSQSVAGSPPPTKSEKKHKDKKRSREEAEEVPAVEDAPKKHKKSKSESLETETTDKKAKRSKKSKKSKLEAEPEQPEEEEEKPEQEAAVASESEAEEKKKRKSKDKKEKKEKKDKKDKKKRQASATPEPEPETTTDAMDVDTTTTFPTDDDADFPFYTQVHSLYVPFYPCGFDKPITNVAAQHLEPLLNHYSPVLRGVLLRYTNLNLSERPVQASVINPPTDKTPALLRSVDEYAVGFAYLTFDAHIFKPARGKWMEGVVQLQSEGHIGVQCWGRFNASIEAKRLPKGWKWVDLKGDHKSYNQQEEEQQEEEEQQEEEDQLDGEELQVVEQVHTTGYWVDASGKKVSGKVRFRIKNFDVGLAGDYGYLSLEGTFLNDQDERALQKEERELERKRRSRQNPGGLLRPMSRRVPEFSMTKFGKEEEEEDAGQRTVFAKVTGKEGDVTPDD
The following text describes a protein:
Function:
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal region is involved in phosphatidylethanolamine-binding and is required for ATG8-PE conjugation; The flexible region (FR) is required for ATG7-binding; The handle region (HR) contains the ATG8 interaction motif (AIM) and mediates binding to ATG8. It is crucial for the cytoplasm-to-vacuole targeting pathway (By similarity).
Sequence:
MSLRSKLSSLREYLTPINHNSNFVTTGEISPEEFVKAGDYLVYKFPTWQWGNDCPKNLQKSFLPPDKQYLVTRHVPSYQRASNYLTGEDKKGANPEEDDEEEEEEDEEGWVKSKKIHKVIDDTHDSQINKGEEINDIDDFIDENAEEQEHDQIGDHELDDDEFDDLDIINDSKNNKLRRFDLYITYSTSYRVPKLYLVGFDSNGIPLLPQQMFEDINSDYKDKTATIENLPVAHNTTSVSIHPCKHSSVMKVLMKHSKLNKKNLQQKDESLSDDLSKLSVNEKKTQDEHSQINNDDKEEEEEGIRVDHYLIIFLKFIASVTPGIEYDYTMDAL
The following text describes a protein:
Function:
Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MISSSRRLFASSILSTARGLIGKGKQTGQDKVTGLFGNDLLKTAQGFAALTEQVKAKCGPLLERIEKGDKERTRVQLVDDLSNELCIAADLAECVRNLHSEPEMAKAAEMAIRELYTLLETLNTYQPLYENLKLSKETEKERLNEVDLRTLDLLVEEFEQSGVHLPDKEREEFVKISGEIFDAGVTFESGCDRNVEVGKSEKATFKLDSRLVSPVSHSSSRDKRKYVYNQFMKHSDEQESSLRKLITARHSLAKLTGFESYAHRSQKNSLLGSYENAHDFLWGLIQRIRPSAERELAVLSDVLHQCDHKSTRVGEWDLFYLTEMYKKSAFGSVPSSVLTQFVTLGNVLRGFGRITQSLYGVTFEQRIPLSGEMWEGAILKLLETGIWQSPVIVLSLNLIPQPNGASISSIPITMKAAENIFHELGHAMHSFLGRTIHQHVSGTRCPTDHAEIPSTLMEYFFYDINVMQKTLCTTDGKSIDIKDAATASYALFDLELHSPQVSESFINGKVSSTQILNRILSRALPNVERDEWTAYQHRFHHLIPYGSKYYSYLVAKASASLIWRNHFHADPYNREAGEKWAEAQSHGGGLPSSVILSRMLGSPPTPSLLIDTLASQSQQASNIPVVNNLIVSML
The following text describes a protein:
Function:
Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle pole. Mitochondrion outer membrane; Single-pass membrane protein. Nucleus.
Sequence:
XESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVGVGEGQGPHSPQLRKKGPHPFLSGLQYGSRQDFLWRLARAYSDMCELTEEVSEKKSYALDGKEEAEAALEKGDESADCHLWYAVLCGQLAEHESIQRRIQSGFSFKEHVDKAIALQPENPMAHFLLGRWCYQVSHLSWLEKKTATALLESPLSATVEDALQSFLKAEELQPGFSKAGRVYISKCYRELGKNSEARWWMKLALELPDVTKEDLAIQKDLEELEVILRD
The following text describes a protein:
Function:
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase.
Sequence:
MELRADLRSILQYLPLVAQSSSLVWPPSVEEELQTISRGPSESMVNSGEALALHITNMRKSLSLNASDLAPYALQGYGLFFDKKISREESANFFGEVVPALCRLLLQLPSMLEKHYQKADHVLDGVKSGLRLLGPQEAGIVLLSQELIAALLACSFFCLFPEVDRSLKNLQGINFSGLFSFPYMRHCTKQENKIKCLIHYFGRICRWMPTGFVSFERKILPLEYHPHFVSYPKADSWANSVTPLCSIEIHTSGAIEDQPCEALEVDFADEYFGGLTLSYDTLQEEIRFVINPELIAGMIFLPRMDANEAIEIVGVERFSGYTGYGPSFQYAGDYTDNKDLDIFRRRKTRVIAIDAMPDPGMGQYKLDALIREVNKAFSGYMHQCKYNIDVKHDPEASSSHVPLTSDSASQVIESSHRWCIDHEEKKIGVATGNWGCGVFGGDPELKIMLQWLAISQSGRPFMSYYTFGLQALQNLNQVIEMVALQEMTVGDLWKKLVEYSSERLSRRTWLGFFSWLMTSLST
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MARLLQHPPKFLPSEWHIANKNQCHKAEAQRSRSERLVAESQRLVDEIEKTTRKSQSDVNKKLEQRLEEIRFWKKELDDKLEQLVFATEDLLIYQTRLEKALESLKEPLHITQTCLEYREKRVGIDLVHDEVEQELIKEADVIQGVMALLTRTLEETTEQIRLNRSAKYNLEKDLKDKFVALTIDDICFALNNNSPNIRYSENVMRVEPNSVSLEDWLDFSNTNVEKADKQRNSSLLLKVLVDRVLSQTASDLHKQCDVVDTAFRNGLKETKGARDKLADHLAKVMEEVASQEKNVAVLEKAILDQEGPAKVAHTRLETRTHRPNVELCRDVAQYRLRKEVQDITHSVARLKETLAQAHTELKGLNRRQLALQEEIQVKENTIYIDEVLCMHLRKSIPLRDGDDHGEWAGGLRPDAVC
The following text describes a protein:
Function:
Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MTRRTMEKPFGCFLLLFCFTISIFFYSAAALTDEEASFLTRRQLLALSENGDLPDDIEYEVDLDLKFANNRLKRAYIALQAWKKAFYSDPFNTAANWVGPDVCSYKGVFCAPALDDPSVLVVAGIDLNHADIAGYLPPELGLLTDVALFHVNSNRFCGVIPKSLSKLTLMYEFDVSNNRFVGPFPTVALSWPSLKFLDIRYNDFEGKLPPEIFDKDLDAIFLNNNRFESTIPETIGKSTASVVTFAHNKFSGCIPKTIGQMKNLNEIVFIGNNLSGCLPNEIGSLNNVTVFDASSNGFVGSLPSTLSGLANVEQMDFSYNKFTGFVTDNICKLPKLSNFTFSYNFFNGEAQSCVPGSSQEKQFDDTSNCLQNRPNQKSAKECLPVVSRPVDCSKDKCAGGGGGGSNPSPKPTPTPKAPEPKKEINPPNLEEPSKPKPEESPKPQQPSPKPETPSHEPSNPKEPKPESPKQESPKTEQPKPKPESPKQESPKQEAPKPEQPKPKPESPKQESSKQEPPKPEESPKPEPPKPEESPKPQPPKQETPKPEESPKPQPPKQETPKPEESPKPQPPKQETPKPEESPKPQPPKQEQPPKTEAPKMGSPPLESPVPNDPYDASPIKKRRPQPPSPSTEETKTTSPQSPPVHSPPPPPPVHSPPPPVFSPPPPMHSPPPPVYSPPPPVHSPPPPPVHSPPPPVHSPPPPVHSPPPPVHSPPPPVHSPPPPVHSPPPPVQSPPPPPVFSPPPPAPIYSPPPPPVHSPPPPVHSPPPPPVHSPPPPVHSPPPPVHSPPPPVHSPPPPVHSPPPPSPIYSPPPPVFSPPPKPVTPLPPATSPMANAPTPSSSESGEISTPVQAPTPDSEDIEAPSDSNHSPVFKSSPAPSPDSEPEVEAPVPSSEPEVEAPKQSEATPSSSPPSSNPSPDVTAPPSEDNDDGDNFILPPNIGHQYASPPPPMFPGY
The following text describes a protein:
Function:
Has antimicrobial activity against Gram-negative bacterium E.coli ATCC 8739 (MIC=100 ug), against Gram positive bacteria S.aureus ATCC 6538 (MIC=25 ug), methicillin-resistant S.aureus ATCC 43300 (MIC=100 ug), B.subtilis ATCC 6633 (MIC=12.5 ug) and against fungus C.albicans ATCC 90028 (MIC=100 ug).
Subcellular Localization:
Secreted.
Sequence:
MFTLKKSLLLLFFLGTISLSLCEQERSAEDEGEVIEEEVKRGFMDTAKNVAKNVAVTLLDKLKCKITGGC