lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
Subcellular Localization:
Bacterial flagellum basal body. Cell inner membrane; Peripheral membrane protein.
Sequence:
MADILSQEEIDALLEVVDENVDIQNVQKKDIIPQRSVTLYDFKRPNRVSKEQLRSFRSIHDKMARNLSSQVSSIMRSIVEIQLHSVDQMTYGEFLMSLPSPTSFNVFSMKPMGGTGVLEINPSIAFPMIDRLLGGKGSAYDQNREFSDIELNLLDTILRQVMQILKEVWSPVVEMFPTIDAKESSANVVQIVAQNEISIMVVLEIIIGHSRGMMNICYPVISIESILSKMGSRDLMLSETNSKKSRNKELQALLSGVSVDMIVFLGAVELSLKEMLDLDVGDTIRLNKIANDEVSVYVHKKKRYLASVGFQGYRKTIQIKEVIYSEKERTKEILEMLEEQRRGKVGDIMKIEEE
The following text describes a protein:
Function:
Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
Subcellular Localization:
Cytoplasm, cytosol.
Domain:
Based on x-ray crystallography data, the protein would be constituted of 4 tandem ACT domains instead of the 2 predicted from the sequence.
Sequence:
MELHILEHRVRVLSVARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVLNVSSHSGAAVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAQEFDIYREVGGEPVPVTRDDSSNGFPRTQHGPSPTVHPIQSPQNRFCVLTLDPETLPAIATTLIDVLFYSHSTPKEAASSSPEPSSITFFAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGIGSVIEVLQRRQEGLAS
The following text describes a protein:
Function:
Catalyzes the deubiquitination of SPDL1 (By similarity). Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (By similarity). May be involved in the maintenance of photoreceptor function. May play a role in normal retinal development.
Subcellular Localization:
Photoreceptor inner segment. Cytoplasm. Nucleus.
Sequence:
MRLKDPFSLKTADMTKRSNKPKKPRDEDSSDEVGGLTCQHVSRAVDLSSVKKAVTGSLWSVCSDCLKERNVLEGETAGAHDILVCLKCGFQGCNQAEVQHSTKHQQAHHSDSHCITISLTTWKAWCFECKEELSTHCNKKALAQTLDFLQKQSAKATSGTSSKLIKLREEPAEYVDTQRGKSPVNSTLIPVKGINNLGNTCFFNAVMQNLSQTHMLNDLIQDVKEKGHKMKISPSTETNLGSLTVTLPSPEPLTSAMFLFLQSMKESGKGPVSPKILFNQLCQKAPRFKGYQQQDSQELLHYLLDSMRVEETKRIKAGILKAFNNPTEKTADEETKRQVKAYGKEGVKLNFVDRIFVGELTSTIMCEECEHISTVKEAFIDISLPIIEERISKPTNPARLGKSGREQDSLTSHDDSLAAHSQANRNSRRLSGQKLQSRHSSTSHDDRGPDTVSSRQEEDLCVAGRGLSSYRTDTMGSQSDCSEKESNLQDSSNDADSEASESEWSPRIPSVSSHSSTSDKTSITTTLSTTTHNPSLKSNPSSTPLPSIRPQQGGAVEQLVSAVSKLGLVHTSTDTLPISHSQEELSETRDRDRQHHQGAFQVLCHSYTPSSKECSVQSCLHQFTSIELLMGNNKLLCENCTDRRQRQMKRSDKKAEKVYTSARKQMLISALPPVVTLHLKRFHQAGMNLRKVNRHVDFPLLLDLAPFCSATCKNLGSGERVLYSLYGIVEHSGSMRGGHYAAYVKVRTPQRKPEQRRNQSGSREACSAPQGQWVYVSDTTVQTVPESRVLNSQAYLLFYEELL
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Miscellaneous:
MISCELLANEOUS: Present with 74700 molecules/cell in log phase SD medium; MISCELLANEOUS: There are 2 genes for eL22 in yeast.
Subcellular Localization:
Cytoplasm.
Sequence:
MAPNTSRKQKVIKTLTVDVSSPTENGVFDPASYSKYLIDHIKVDGAVGNLGNAIEVTEDGSIVTVVSSAKFSGKYLKYLTKKYLKKNQLRDWIRFVSIRQNQYKLVFYQVTPEDADEEEDDE
The following text describes a protein:
Function:
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.
Sequence:
MNSTKYMQRMAKDRESYPNPPVTKTYKLNGSIADVLAVHLPHGADVVLLRLERHEPVALALVRLAVAHNLEKLNLHRTRGSRWGPTRPARGPPTAPRQHIARTASSSSRHAALARVFISSIFLFGSSALAGAYICGFDSMVAGGSMSPPALVSAAAAPKLTMEATGGTRRGTAKFASLDPNLVVFLPVGISTTGGTGGAVMEGGAEMVLALPVPEGAADVDGAASGSSEFVVERGHYPKRQSVSPRQVYALIIAMYFNADKERPVGAVITGGKLLKKSKKSLEQLKRHDPDVEVANEPTKILFVANSSVLCSVSPEELQEIFTQFDASVELIVFPNRRAYSFIEFSTIEAASRAKEELNGKVPEQLRKSHLPFVIEFVKNLPLSKTADGVAGPRDLQIVDDFVDQGIERDLIDMVMTDPRLNEMKHRSVLHWGHAFDYSTNSAFVPIEKIPSRLEMIVDRLIEKGHITERPDQITANVYSPGQGIPSHFDTHSAFEDPVVSLSLLADVVMEFKDAANSARVAPILLPRRSLCLIQGDSRYRWKHGIVNRQYDVCPRTNRLLPRQQRVSITFRSVASRAAATTRSSATGTGTARWRSLPPPLPRAPSRAATSRTFLDSIPRGSLLYDIGCGNGKYLLPERNDGLIKIGADRCLGLCEIAASKGCCVVRGDALGAPLRAGADAVISIAVLHHMSTAERRRKAVEEIASLLRVGGRACVTVWSLEQGQSEYAKMRENREENGGNKEEERERREENGRLLVHDGREFVQQDLLVPWTVAGKEARKAKEEDESKEEETFLRFYHVFAEGELAELVQSVDGLKLESIELEQGNYVAVFERIRSDRVPTGAKPVCLLESFSSKFLLARAYVPSARMAGSVSGSGGGGTSNGQAAVGLSTERIAGVKRRSPPSSGLYTTGLIYAAIQVAFLSFLCSYYEVGPTDAGAWVMQRLQENDYTRAKLEYVQSLVGGFAAPSKKSKRSMAEGETFDPMVKEGDDGVVNVLTPEQLGLFDGSRSSRPVYLAIVGRVYDVDKGKKHYGKGGGHEDILGIRDWVAFYEKDYKLVGVVAGRYYDAAGAPTEEMTNFLSRVQVATEWREAKAAEAEVFPPCNSEWHKDSGGRVWCTKRSGGIEREWSGLPRLYLDPATNQKRCVCVKNFGEGLSVHAQASGSNRGDLDHPALELYPNCKETANSCKIESD
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MADHTTKEQKSFSFLAHSPSFDHSSLSYPLFDWEEDLLALQENSGSQAFPFTTTSLPLPDLEPLSEDVLNSYSSASWNETEQNRGDGASSEKKRENGTVKETTKKRKINERHREHSVRIISDITTYTTSSAPTTLSKETVSRYFYMPITQAAIALNVGLTLLKRRCRELGIRRWPHRKLMSLNTLISNVKELQKMEGEENAEKLQDALEMLEKEKRTIEDLPDLEFKDKTKRLRQACFKANHKRKKKRSLKSDQSQVPSCSSSGSVPSDESVDEAGMESDEEMKYLLCGFSSEFTSGL
The following text describes a protein:
Function:
GTPase-activating protein (GAP) for Rab35 which regulates synaptic vesicle (SV) protein recycling and turnover at the neuromuscular junction boutons and possibly ventral nerve cord via endosomal trafficking. Inhibits Rab35-mediated endosomal sorting which traffics old or dysfunctional SV proteins through a degradative endolysosomal route that involves the ESCRT pathway and the HOPS complex members dor, vps39 and rab7. This function is essential for preventing excessive degradation and turnover of vesicles from the readily releasable pool which leads to increased neurotransmission and eventually neurodegeneration. Preferentially binds phosphoinositides phosphorylated at the D5 position of the inositol ring, such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). Binding to phosphoinositides and thus membrane-association, is required for its function in regulating the turnover of synaptic-vesicle proteins. It is therefore likely that it is recruited to vesicle membranes with high phosphoinositide content and thereby selectively prevents endolysosomal degradation of these vesicles.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Detected at the synapses of neuromuscular junction boutons, where it displays co-localization with Rab35. Associates with certain types of membrane phosphoinositides such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3).
Domain:
The Rab-GAP TBC domain is essential for phosphoinositide binding.
Sequence:
MPYHRGGDASSQADKLSGIVEESDLYEGFAPHVETSEIKTLDFYNLPKQTGKEPALRSYTEIQQLLQQGKKRDVKNILRENSWPINSPIRAQLWPMLCGQHQTKQQMLDGFYWEMVHQVFGTTELSEKPIMLPAFVDATHCLPYHLTSTGRAVADRIVNVLGYDCPDITYSPVLYPITSILLHFMSEEEAYICLAGLVGSKEKVFINQTKLQHEVTWKTVMQIAKKHTKSATSYFQRICPGLKLERIFMDWCWWILAGLPFQHLVRIMDCYFHEGIKVLYRVALVILNLFHKECQSNNEWSPDNIKNDIGNALIKFCKKIPVSPAKLLHAAFSIRGLSTQYISRIFIKTEMLLKSRSVLTSGSKQLIKSRSSDNLPTSQSQVNIQMMSHTLTIREHFGLPGTKNFIKTWTDRQFLFTLWSWLPVRITMYQPVLLYTTEEHGCSLTTFYVRVEQHEPTLLMIKTCNNEVFGAYCSSRWFERNVKDDKGQRQAYFGTGETFLFSLYPERAKYPWVGIEGDKDLGHSSELFMAADSKMITIGGGEGQAIWMDENIRFGKTDSCKTFNNPPLCPSGDFEIRVLEVYGFVGI
The following text describes a protein:
Function:
Putative prephenate dehydratase required for the synthesis of L-phenylalanine.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSASKIAFLGPRGTFSHQAALLARPDSLLCSLPSFAAVLEALSSRQVDYAVLPIENSTNGAVIPAYDLLKGRDDIQAVGEVLVPAHHCIIGKSLENVQKILSHPQAFGQCSKWISANVPNAEFVSVSSTSQAAALASKDITGTIVAISSELCAVENQFNLLVKNIEDDSNNRTRFLLLRSGGFQDDLSPLKEKSLLQFYLSHPKKLSAVFEVFAAHKVVITNLVVRPSCKFPWTYIYFVECLGMEKHLIDRVGKYCDTFTFMGSYTNQISYF
The following text describes a protein:
Function:
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
Sequence:
MILTSLSLYLYRLPLDSFLPVGKQRIDHRKGLVLQAKATADGEVCDTEISNAEVTDSEVTEGEVKESHVEIAPLSGFDIDQQPLSGFSRESLDEVQQALTVLLPKLQNQSIDCLLEQAEASPYPSIAFGLSLLHAKLSGKLDAVRPLTTAVPLIYQPTDAPKAELIAKIASLKPSVRSVKVKVAQTSMEDELSLIYGILSQRPDLKLRLDANCGFSLEQALDFAACLPLDSIEYIEEPCQHPQDNHTLYRAIPLPYALDESLNDPDYQFVMHEGLTALIIKPMLLGSIEKLQRLIDEAHNHGVRCILSSSLESSLGINDLAHLAAILTPDEIPGLDTLTAFSQDLLVPSGKLQCLTLQCLTLNQLERVASTVQD
The following text describes a protein:
Function:
Binds sperm in vitro but has no effect on sperm capacitation. Also binds gelatin and heparin, but not chondroitin sulfate B or phospholipid liposomes.
Subcellular Localization:
Secreted.
Sequence:
MEVMSHLVHWVFLAVYMYELNAELISHLHPPEQEISTDSCVFPFVYADGFHYSCISLHSDYDWCSLDFQFQGRWRYCTAQDPPKCIFPFQFKQKLIKKCTKEGYILNRSWCSLTENYNQDGKWKQCSPNNF
The following text describes a protein:
Function:
Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
Sequence:
MQSWYCPPVPVLPGRGPQLRLYDSADRQVRPVAPGSKATMYVCGITPYDATHLGHAATYVTFDLIHRLWLDLGHELHYVQNITDIDDPLFERADRDGVDWRDLAQAEVALFCEDMAALRVLPPQDYVGATEAIAEMVELIEKMLACGAAYVIDREMGEYQDIYFRADATLQFGYESGYDRDTMLRLCEERGGDPRRPGKSDELDALLWRAARPGEPSWPSPFGPGRPGWHVECAAIALSRIGSGLDIQGGGSDLIFPHHEFTAAHAECVSGERRFARHYVHAGMIGWDGHKMSKSRGNLVLVSALRAQDVEPSAVRLGLLAGHYRADRFWSQQVLDEATARLHRWRTATALPAGPAAVDVVARVRRYLADDLDTPKAIAALDGWVTDAVEYGGHDAGAPKLVATAIDALLGVDL
The following text describes a protein:
Function:
Component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach (Probable). ADC can be found in two forms: biodegradative (this enzyme) and biosynthetic (speA). The biodegradative form plays a role in regulating pH by consuming proteins. Converts arginine imported by AdiC to agmatine which is then exported by AdiC (Probable).
Subcellular Localization:
Cytoplasm.
Sequence:
MKVLIVESEFLHQDTWVGNAVERLADALSQQNVTVIKSTSFDDGFAILSSNEAIDCLMFSYQMEHPDEHQNVRQLIGKLHERQQNVPVFLLGDREKALAAMDRDLLELVDEFAWILEDTADFIAGRAVAAMTRYRQQLLPPLFSALMKYSDIHEYSWAAPGHQGGVGFTKTPAGRFYHDYYGENLFRTDMGIERTSLGSLLDHTGAFGESEKYAARVFGADRSWSVVVGTSGSNRTIMQACMTDNDVVVVDRNCHKSIEQGLMLTGAKPVYMVPSRNRYGIIGPIYPQEMQPETLQKKISESPLTKDKAGQKPSYCVVTNCTYDGVCYNAKEAQDLLEKTSDRLHFDEAWYGYARFNPIYADHYAMRGEPGDHNGPTVFATHSTHKLLNALSQASYIHVREGRGAINFSRFNQAYMMHATTSPLYAICASNDVAVSMMDGNSGLSLTQEVIDEAVDFRQAMARLYKEFTADGSWFFKPWNKEVVTDPQTGKTYDFADAPTKLLTTVQDCWVMHPGESWHGFKDIPDNWSMLDPIKVSILAPGMGEDGELEETGVPAALVTAWLGRHGIVPTRTTDFQIMFLFSMGVTRGKWGTLVNTLCSFKRHYDANTPLAQVMPELVEQYPDTYANMGIHDLGDTMFAWLKENNPGARLNEAYSGLPVAEVTPREAYNAIVDNNVELVSIENLPGRIAANSVIPYPPGIPMLLSGENFGDKNSPQVSYLRSLQSWDHHFPGFEHETEGTEIIDGIYHVMCVKA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MPRGRPPKPRDSGPSAAHCDGVLTLNAENANYAYPAPNFHKCDICLLSFPKETQFQRHLRDHEQNDKPHRCDQCPLSFNVEFNLTLHKCTHSGEDPTCPVCNKKFSRVASLKAHIMLHEKEENLICSECGDEFTLQSQLSLHMEEHRQELVGSQSHTCKACKKEFEASSQLKEHMKTHYKIRVSKTRSYNRNVDRSGFTYSCPHCGKTFQKPSQLTRHIRIHTGERPFKCSECGKAFNQKGALQTHMIKHTGEKPHACALCPAAFSQKGNLQSHIQRVHSEVKNGPTYNCTECSCVFKSLGSLNTHLSKMHMAGPLNQPSAPPDPAHGSVGSGPQTPAASATPLLQSAENKWKNQTDPPAPPAATPPAPQAVTDVIQQLLELAEPSPVEANAPQTPASQQLSIAVGLNQDILQQALENSGLSSLPVAATPGDPAQAKPAAAGAVPTPSPELLNVSSQHTDPSEAEQEKDRDSPDKLDKKEKKVIKKKSPFLPGSVREENGVRWHVCPYCTKEFKKPSDLVRHIRIHTHEKPFKCPQCFRAFAVKSTLTAHIKTHTGIKAFKCHFCLKCFSTSGSLKVHIRLHTGVRPFACPHCDKKFRTSGHRKTHIASHFKHTELRKLRHQRKPARVRMGKANVPMPDIPLQEPILITDLGLIQPIPRNSQFFQSYFNNNFVSEADRPYKCIYCHRAYKKSCHLKQHIRSHTGEKPFKCSQCGRGFVSAGVLKAHIRTHTGLKAFKCLICNGAFTTGGSLRRHMGIHNDLRPYMCPYCQKTFKTSLNCKKHMKTHRYELVQQLQQHQQAASIHDTTVDQQSIPVSTQMQVEIESDELQQAGAVAADPDAILELEQPHVVGPEEAALGQPLTDQPLETEEDRFVTSQHALQDNIAQFEQQTLPQQPFEQTGLSQGFTGSDSYSQQNPFPPVQQLQDSSTLESQALSTSFHPQNLLQVSGTEPLNEPTRLIQEPSQDELELQPQRPPQLLEESEEQTRRAYRCDYCTKGFKKSSHLKQHVRSHTGEKPYKCKICGRGFVSSGVLKSHEKTHTGVKPFTCNICAAAFTTNGSLTRHMATHMSMRPYKCPFCEESFRTTVHCKKHMKKHQAVSSAVATSGEAGGGGEAEGGSGDGEGGGGVGCLEEEDENSDRAASRRPRPGVITFTEEETAELAKIRPQESATVSEKVLVQSAAEKDRISEMKDKQAQLEAEPKYANCCTYCPKSFKKPSDLVRHVRIHTGEKPYKCEECGKSFTVKSTLDCHVKTHTGQKLFSCHVCSNSFSTKGSLKVHMRLHTGAKPFKCPHCDLRFRTSGRRKTHIQCHYKPESKKARKPPVRTPAESLQPVSLLGAPSADPSVFIMNNSVLAAQLDQNLLQQGLVGQAILPASMSAGGDLTVSLTDGSLATLEGIQLQLAANLVGPNVQISGIDASSINNITLQIDPSILQQTLQQSNLLAQQLTGEPHLTPPSTALQTQDGPVPANVVIQPISGLSLPAAVAPSANMTIGPLSEQEAVLGPGSSGPQDLSQVMTSQGLVSTSNGQHEITLTINNTSLSQVLAHATGSTTPTSAGSPQEITLTISGQDLIQHNPSGSIRLSSPAVSTQPNAATLTISHDQLLSQSSALNSSPELNAATGSLPAPAPMSPPPVSASNLVMSSSGVGPDASVTLTLADTQSMLSGGLDAVTLNITSQSQQFPALLTESSLSSPSGAGPQQVILVSHTPHSTTPHSEDITFQVTEGSPPLSQGSPTEKGGRGHQCLECSRTFPSASTLMHHSKEVHGKERIHVCHACSKAFKRATHLKEHLQTHQAGPSLSSQKPRVFKCDTCEKAFAKPSQLERHSRIHTGERPFHCTLCEKAFNQKSALQVHMKKHTGERPYRCEFCAMGFTQKSNMKLHVKRAHSFTGALQESGGHQEPEGGDLNRALRLEEVVQAPASEWQSLTSIFR
The following text describes a protein:
Function:
Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion outer membrane.
Sequence:
MDFLSARDEVDEEAILPDLSDEILVEQFTRNVQFFGLEGQKRVQASFVIVVGLGGVGSHAAAMLLRSGVGKLRLIDFDQVSLSSLNRHAVATRDDVGTPKAVCLKEHFSRIYPECVIEACSELFDESSAEDLLSGSPDFVLDCIDNIDTKVFLIATCNKKSLRVLSATGAGARADPTRVRIADVCESSIDPLSRAVRHRLRRLHGIESGVPVVFSMERPKAKLLPVNGVDGQEGNPSDYQIVPGFRVRIIPVLGTIPAIFGQVMASYTIAKLAGLQVETEPVVNLDVEHYAVLHRRLIEREELLYGTADAVEVDKEEVAYVVRELWRGKSARNQDSHDVGRGMWRSVNKLTLTRWDHKQPPSVSNLILLTFQEAEKHEASSVEEIKEQEPAFYAMVTETLNRGKKEF
The following text describes a protein:
Function:
Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.
Sequence:
MTEEFNESMINDIKEGDKVTGEVQQVEDKQVVVHINGGKFNGIIPISQLSTHHIDSPSEVVKEGDEVEAYVTKVEFDEENETGAYILSRRQLETEKSYSYLQEKLDNNEIIEAKVTEVVKGGLVVDVGQRGFVPASLISTDFIEDFSVFDGQTIRIKVEELDPENNRVILSRKAVEQEENDAKKDQLLQSLNEGDVIDGKVARLTQFGAFIDIGGVDGLVHVSELSHEHVQTPEEVVSIGQDVKVKIKSIDRDTERISLSIKDTLPTPFENIKGQFHENDVIEGVVVRLANFGAFVEIAPGVQGLVHISEIAHKHIGTPGEVLEPGQQVNVKILGIDEENERVSLSIKATLPNEDVVESDPSTTKAYLENEEEDNPTIGDMIGDKLKNLKL
The following text describes a protein:
Function:
Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1.
Subcellular Localization:
Endosome.
Sequence:
MTNPWEEKVCKMAQTSLLQGKQFYCREWVFHKLQHCLQEKSNCCNSAVNAPSLVMNSGNNASGVSGKGAAWGVLLVGGPGSGKTALCTELLWPSSPASLQRGLHRQALAFHFCKAQDSDTLCVGGFIRGLVAQICRSGLLQGYEDKLRDPAVQSLLQPGECERNPAEAFKRCVLLPLLGMKPPQQSLYLLVDSVDEGCNITEGEQTSTSLSGTVAALLAGHHEFFPPWLLLLCSARKQSKAVTKMFTGFRKISLDDLRKAYIVKDVQQYILHRLDQEEALRQHLTKETAEMLNQLHIKSSGCFLYLERVLDGVVENFIMLREIRDIPGTLNGLYLWLCQRLFVRKQFAKVQPILNVILAACRPLTITELYHAVWTKNMSLTLEDFQRKLDILSKLLVDGLGNTKILFHYSFAEWLLDVKHCTQKYLCNAAEGHRMLAMSYTCQAKNLTPLEAQEFALHLINSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNGPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHNLSFTEQIQQHSLPRSRSRQSIVSPSSTTQSLGQSHNSPSSEFEWSQVKPSLKSTKASKGGKSENSAKSGSAGKKAKQSNSSQPKVLEYEMTQFDRRGPIAKSGTAAPPKQMPAESQCKIMIPSAQQEIGRSQQQFLIHQQSGEQKKRNGIMTNPNYHLQSNQVFLGRVSVPRTMQDRGHQEVLEGYPSSETELSLKQALKLQIEGSDPSFNYKKETPL
The following text describes a protein:
Function:
Transcription factor that regulates the expression of genes in response to changes in temperature. In particular, binds to the promoter region of genes such as asp-17 in response to severe cold to warm temperature transitions to promote gene expression. Promotes stress-induced death, particularly in older animals, following cold shock followed by warming and this may have evolved as a form of kin survival under thermal stress conditions, favoring the survival of younger animals.
Subcellular Localization:
Nucleus.
Sequence:
MTTMTNSLISNSVSSVPESLFSSASIHRPVAINPAMLAQFSINLPVLPFESSASLGTSTTSSSRCSSTESSAAPGKIRRGRPQQEIADGQDAHSQKKRHRRLYARQYRAQMRQKVENVKSLHDEKEQLELEVKALRQAVSGLQQENAQKDFLISILQLNNQINHS
The following text describes a protein:
Function:
Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
Sequence:
MIPDLEKDYLYFTRVVKRDLGLDLALYKETQMKRRILSFIVKKKYITFGEFFKHLKKDAVLLDEFISLITINVSSFFRNRNRWDALEKQVLPRLLEDSRGKLRVWSAACSSGEEPYSLAMMMERSVGTRHYDILATDLEPAILKRAVIGEYQSRQMEELSEQERHTAFVEKGDTYQILPKYRKSIRFRRHDLLTDYYEKGFDLIVCRNVLIYFTAEGKHQAYQKFAESLRRGGVLFIGGSEQILNPADYGLATLNNFFYIKT
The following text describes a protein:
Function:
Involved in the ingression of the plasma membrane during cytokinesis, leading to the separation of the daughter cells. Unlike its S.cerevisiae ortholog INN1, it does not play an essential role, probably because the actinomyosin ring is connected to the cell cortex by many more proteins.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes at the barrier septum and the cell tip.
Sequence:
MSKNPLGTLVVRIWKAKNLPNKALVGKQSPYCVCRVGEVVKRTQTDKRSGQEPSWNAVLEFNIPSESYHIMKITVFHEGFRKHPHLIGDTVLSFEKAMKEELQSEWYELKNEFQFAGELSVQFKFIPTDPLYFDRASSKPVLQFPYSSVAALTPVPKKPSKPSKPRKKVPVSHPLPPTPPSREEHVSVPRESSLFTYEDDPLPSFPSPYMVDDYYTQDVFVSDNVNDYSYGVQNPTNPRLSVEDYDANHSSLPPVPPPHLILPTASSSQIFH
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Sequence:
MTTHSKMAATTIFLTRILRHSSRLTINQSLLRSLASTSTTTTTTTTTTTSAILSDESTKSIQTIEKDIKPIEEKVQKTKPSKAKEKTEDVKSSEQETKELPPDKTDSSESLTSPKDGGDKAASTSEDLQKVTKNQQTAANNQSKEETKNQQKAANNQPKKTKNQPKKTENQPKKTENQPKEETKNQQKAVKNQSKEATKNQQEATKNQQEAAKNQLKEETKNQQNAAKNQPKMATKNQQKAAENQPKVAKIQQKAAKNQPKKTENQPKKTKNQPKKTQNQPKETKNQPKETKNQPKEAKNPHTALQDQPKETQNPQKAVEDQSKVTKSSTAKASNTPSTTEEATSQAVKPEVAQSLKPLPLPKTIRSQEEKAITTIDSDLIKFDQFVTIGSPPSQNPSMYTKKIAKFILDSRLRFPDAILLTCVGSFYEAYFDQAVEVAQLLNIKQAQYQFAGKTYPFSGFPIASLQKHLKTLVNEHNRIVAIAEQISTDEELERRIVRIITPGTITDENLIDDESYNYLLGIHQNQLAWLDVSTGSYFSTTCEGGESELLDQICRISPKEILISADSSFRIPPNSKAAKLSMLITKIKSDASISPDELSAEKLIGIYIKRNLLPSRAAIQPLCVDTFRHLKLDAEAIDSLEIIRTQNGKSAAGSLLSTISRTITRPGKRLLRDRIMSPSRVPAEIQSRLDLVGKLVVNHISREDIQDTLKDIEEIDYVRLLQRFNLGQGSIQDLMSIVRILKAIKTISSTLSDLGIPSRLGCHLALEENISKAIDELTPAHGQIASEEASIEEAKDFFSPASWNVRSDLNKELSSMHQRFTALMEKGKELQAKYRNDFNSKDLKLQVVPKLGAVLIVNKARKPSSELKSKLDNLKGQTLIDNGSRVVVAVPDWTKMHASIEKLRQELVQAEQRVLKRLFEQVASDHVTLNPSFHDLAELDVAQSFATFAVETNCVRPSINSKRSTAIVNGRHPIAERALSSSANGSFIPNSIVMHDNDGLVQIITGPNNGGKSTYLRQLAIMHILAQAGSFVPAEKAKLGLVHQIFTRFGSFDNVVLGKGTFLIEMEETCKILKSADEMSLVLMDEVGRGTGIEDGLSIAYGVLKYLIEKNQCRTLFSTHLPHVGSLLLRKDMGTNVSSSSNANLDGLKAKEYLKIAKLGFFCFGSSKIHGDGKKGKQEEILNFPYRIQRGLNPDSSGIDIAKLVGLPKEVISHATTIKRQLGNYSLRFEQDHKA
The following text describes a protein:
Function:
Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3'. Positively regulates the determination of retinal ganglion cell fate and formation of the optic nerve and retino-hypothalamic tract. Required for retinal circadian rhythm photoentrainment. Plays a role in brainstem auditory signaling and binaural processing. Regulates the differentiation of olfactory receptor neurons. During retinal neurogenesis, activates the transcription of several genes such as brn3d, coe3, cbfa2t2, glis2, elrC and xgadd45-gamma.
Subcellular Localization:
Cell projection, axon. Nucleus. Perikaryon.
Sequence:
MARLLHGAATAADWCELKELPSEAGLLARDYLLDSSDPRAWLSATSLQSRPEYVLHPPGRAHKVRELCKLKGLRDDDDEEEDDEEEEERSEGLCRHRGPPGKGPGGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSDLLQAPPDSRDPPCPPTYQLHSGPEPRLGQSGSCMRFSGDFPGQSPLSFQFQEGAALSQKGIGSAPSSSSGEDSKTSPRSHRSDGEFSPHSHYSDSDETS
The following text describes a protein:
Function:
Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site. In response to insulin and nutrients, AKT1S1 dissociates from mTORC1. Its activity is dependent on its phosphorylation state and binding to 14-3-3. May also play a role in nerve growth factor-mediated neuroprotection (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Note=Found in the cytosolic fraction of the brain.
Domain:
The TOS motif mediates interaction with RPTOR, leading to promote phosphorylation by mTORC1 complex.
Sequence:
MASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIALAHRAATAARPPAPPPAPQPPSPTPSPPRPTLAREDNEEDEDEPTETETSGEQLGISDNGGLFVMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPTCSVPPASALPTQQYAKSLPVSVPVWGFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLPRPRLNTSDFQKLKRKY
The following text describes a protein:
Function:
May regulate the dynamics and distribution of mitochondria in neural cells.
Subcellular Localization:
Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MSRVRDAGCVAAGIVIGAGAWYCVYKYTRGRDQTKKRMAKPKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVAPAASSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAGAPKVAEAPREAETSRAAVPPGTVVPTEAAAPTEVTEGPGVAAPTKVAEAPGVASPTEAAEAPVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKATPGAHTGAIPKATSATGAVPKGGGKGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAEVPDSEEGESGWTDTESDSDSEPETQRRGRGRRPVAMQKRPFPYEIDEILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQETIRKLGGLPIIANMINKTDPHIKEKALMAMNNLSENYENQGRLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANFFRLLSQGGGKIKVEILKILSNFAENPDMLKKLLSTQVPASFSSLYNSYVESEILINALTLFEIIYDNLRAEVFNYREFNKGSLFYLCTTSGVCVKKIRALANHHDLLVKVKVIKLVNKF