lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Negative regulator of multiple nitrogen catabolic genes including the allantoin pathway genes.
Subcellular Localization:
Nucleus.
Sequence:
MVLSDSLKLPSPTLSAAAGVDDCDGEDHPTCQNCFTVKTPLWRRDEHGTVLCNACGLFLKLHGEPRPISLKTDTIKSRNRKKLNNNNVNTNANTHSNDPNKIFKRKKRLLTTGGGSLPTNNPKVSILEKFMVSGSIKPLLKPKETVPNTKECSTQRGKFSLDPCEPSGKNYLYQINGSDIYTSNIELTRLPNLSTLLEPSPFSDSAVPEIELTWKLHNEEEVIKLKTKISELELVTDLYKKHIFQLNEKCKQLEVELHSRASVQSHPQH
The following text describes a protein:
Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
Subcellular Localization:
Zona pellucida. Cell membrane; Single-pass type I membrane protein.
Domain:
The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
Sequence:
MSVSQPFALGVVLSTLCVFVTHSQGFAAWLGDISRNRARTRVRPDIPGPISPRLSPPPAPAPDVQLRAQERPRIRVQCGEATVRVSVDRLYFGEPGPVSAASLRLGEDPRAPGSCTPEPTASVPGAALVITARLHECGSVSRVTPQALVYLNKLVYSPSPAGGVLERASPVLVPLECHYRRKHRVSSEAVRPTWLPFTSTRSAGGLLRFSLRTMNEDWGSPRLSSVFYLGETVRLEAAVSSQGHPPLRLFVDRCVAT
The following text describes a protein:
Function:
Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MINRQLSRLLLCSILGSTTLISGCALVRKDSAPHQQLKPEQIKLADDIHLASSGWPQAQWWKQLNDPQLDALIQRTLSGSHTLAEAKLREEKAQSQADLLDAGSQLQVAALGMLNRQRVSANGFLSPYSMDAPALGMDGPYYTEATVGLFAGLDLDLWGVHRSAVAAAIGAHNAALAETAAVELSLATGVAQLYYSMQASYQMLDLLEQTHDVIDYAVKAHQSKVAHGLEAQVPFHGARAQILAVDKQIVAVKGQITETRESLRALIGAGASDMPEIRPVALPQVQTGIPATLSYELLARRPDLQAMRWYVQASLDQVDSARALFYPSFDIKAFFGLDSIHLHTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAVNGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGGGYQAGPVVEKK
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Cell membrane. Endomembrane system; Multi-pass membrane protein.
Sequence:
MMIRSCKGLRCLPEGIRFLTSLENIPLVSLHCGLVARCSFFLGAHFSSSCMAIVDDEGSEPLYEECWKRYASFISFMNLLITILFSHFNFYVLWYDLITQFWDHLLSEGNQDVHVIFLTTNTYCDSRVVCKYYENWGATFSIVYYHRDQCDADLVNVTNQNSRSKLLARNVVEHMDAAVRYATLAPPVKGKMFKELSVCYTVVAVTFFSVAISGYWAYGNESEGLILSNFVDNGKPLVPKWFIYMTKWFLIQVYLQPTNEVLEQTFGDPKSPEFSNRNVIPRPISRSIAITISTLIAAMLPFFGDINSLIGAFGFMPLDFVLPVIFFNLTFKPSKRSLIFWLNVTIAVVFSALGAIAAIAAVRQIILDAKNYQLFANV
The following text describes a protein:
Function:
Catalyzes the attachment of glycine to tRNA(Gly).
Subcellular Localization:
Cytoplasm.
Sequence:
MRTWKKGTAVASTSTLDNVINLCKRRGFVFPCGEIYGGTRAAWDYGPFGVELKENIKRQWWRAMVTRRDDVVGLDSSVILPREVWVASGHVGVFNDPLTECLSCHKRMRADHLQEGHAAKHGIADPDSISLEEVNCPNCGNKGQWTEPRDFNMMLKTYLGPVEDKSGLHYLRPETAQGIFVNFQNVLTSARKKPPFGIAQTGKSFRNEITPGNFIFRTREFEQMEMEFFVEPGTDEEWHQYWIDVRTAWYTDLGINPDNLRHYEHPKEKLSHYSKRTVDVEYKFGFSGSDWGELEGIANRTDFDLGNHSRHSGKDLSYYDQANNKRYLPYVIEPAAGLTRSLMAFMVDAYTEDEAPNAKGGVDKRTVLKLDPRLSPVKAAVLPLSRNSDLSPKARDLAARLREHWNVDFDDAQAIGKRYRRQDEIGTPFCITVDFDSLEDDAVTIRERDTMAQQRVSIDKVEEYLGGKLLGC
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MYELLLYGQVPVGRHEQVLKILAGVAAMQPLRILERCIIYKPQREPEEPGLNVRRGGTQNIALKQGNKPATAAAALYYTKLIQKLSEDDFGVEHGKPLSADVKDGEEAKWSMRWEDQPDTGDRGVSIRFTNTTDLLSGDPHAHMIATGPNRFVTEYYVEGHRFVHGNVIIFLHRVLHEPGVRSLEVAPKTQLPDFAALQLLDMSGAYILEVKLRVQDFKDAATLESGVNELKGFQKQMAGCVELSLPDRLSLDTRVKYKPPHAGAAPAQNRPR
The following text describes a protein:
Function:
May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.
Subcellular Localization:
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=The unphosphorylated form is predominantly cytoplasmic. A phosphorylated form is associated with the plasma membrane.
Domain:
The SPRY domain mediates the interaction with MET, AR, and CDC2L1.
Sequence:
MSGQPPPPPPQQQQQQQQLSPPPPAALAPVSGVVLPAPPAVSAGSSPAGSPGGGAGGEGLGAAAAALLLHPPPPPPPATAAPPPPPPPPPPPASAAAPASGPPAPPGLAAGPGPAGGAPTPALVAGSSAAAPFPHGDSALNEQEKELQRRLKRLYPAVDEQETPLPRSWSPKDKFSYIGLSQNNLRVHYKGHGKTPKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINNTCFYTKNGHSLGIAFTDLPPNLYPTVGLQTPGEVVDANFGQHPFVFDIEDYMREWRTKIQAQIDRFPIGDREGEWQTMIQKMVSSYLVHHGYCATAEAFARSTDQTVLEELASIKNRQRIQKLVLAGRMGEAIETTQQLYPSLLERNPNLLFTLKVRQFIEMVNGTDSEVRCLGGRSPKSQDSYPVSPRPFSSPSMSPSHGMNIHNLASGKGSTAHFSGFESCSNGVISNKAHQSYCHSNKHQSSNLNVPELNSINMSRSQQVNNFTSNDVDMETDHYSNGVGETSSNGFLNGSSKHDHEMEDCDTEMEVDSSQLRRQLCGGSQAAIERMIHFGRELQAMSEQLRRDCGKNTANKKMLKDAFSLLAYSDPWNSPVGNQLDPIQREPVCSALNSAILETHNLPKQPPLALAMGQATQCLGLMARSGIGSCAFATVEDYLH
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDINIDDILADLDRDTTAVGSTPAPAGDDTTRLDDSAATVAADYSTLVTHWCNERVAPELLPYPHTLMARVLARLAAQIEHLETLSTGVLEQTLDRSAKLPLLCMEAELERLKFVVRSLLRCRLGKIDRFGLYLRQLDARSPGALQTLLSAQERVYYERHSAILLKLFNNAILRHMPAEMQAVDDTEGSVSMIDEPEWARFVFLYVREPAPDAPDPLLAVDDHGQPCYSVNIPELGEVVDLAVGGIYIMRYNVIKDLLMDGKVVLI
The following text describes a protein:
Function:
Secreted effector that translocates into the nuclei of host cells to reprogram the expression of immunity-associated genes by binding to effector binding elements (EBEs) in rice. Binds the 5'-CAATCTTC-3' EBE of promoters from targeted rice genes and probably recruits a yet to be determined host repressor. Causes ambivalent immunity with increased susceptibility to the hemibiotrophic pathogens Magnaporthe oryzae and Xanthomonas oryzae pv. oryzae, but enhances resistance to Cochliobolus miyabeanus, a necrotrophic pathogen.
Subcellular Localization:
Secreted. Host nucleus. Note=Secreted via the biotrophic interfacial complex (BIC) and translocated into the nuclei of initially penetrated and surrounding cells.
Sequence:
MQLSNFLSIWALVAMGATAAPMPSGSAPGNPFADGEAYGARPSQGLTPVPKVHDGSYHSCETCAAPFRTEERLAAHRQADHGNQGAAARGSGRHTSKNRGSSKTSERERLDRLASRVGEDYVEKRSQEATEEQEQGHVKPGRSKKEIAQRIRNLPVTPWNQYGAAVKLDKPTRKEQYRQLPGNDRLTPFEEQGDPVQL
The following text describes a protein:
Function:
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.
Subcellular Localization:
Cytoplasm.
Sequence:
MLIKSFLDYLRYERNYSEKTVLAYGEDIKQLQEFAQEEYGKFDPLEVEGELIREWIVSLMDRGYTSTSVNRKLSSLRSFYKYLLRQGEVTVDPLRKITGPKNKKPLPAFLKESEMDKLLDDTDFGEGFKGCRDRLIIGVFYATGIRLSELIGLDDKDVDFSASLLKVTGKRNKQRLIPFGDELKELMLEYINVRNETIPERSEAFFVKEDGERLYKNLVYNLVKRNLSKVATLKKRSPHVLRHTFATTMLNNDAELGAVKELLGHESVATTEIYTHATFEELKKVYKQAHPRA
The following text describes a protein:
Function:
ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping.
Subcellular Localization:
Cytoplasm, P-body.
Sequence:
MNNNRGRYPPGIGAGRGGGMNLNPAFQSRVPQQHYVQRSLVQQQNHHQQQQHQYQQQQQQYHQQQQQQQQQWLRRGQLGGADSIVDEVEKTVQSEAVDSSSQDWKARLKIPPPDTRYRTEDVTATKGNEFEDYFLKRELLMGIYEKGFERPSPIQEESIPIALTGSDILARAKNGTGKTAAFCIPALEKIDQDNNAIQVVILVPTRELALQTSQVCKELGKHLNIQVMATTGGTSLKDDIMRLYQPVHLLVGTPGRILDLAKKGVCILKDCSMLVMDEADKLLSPEFQPSIEQLIRFMPANRQILMFSATFPVTVKDFKDRYLQKSYIINLMDELTLKGITQFYAFVEERQKVHCLNTLFSKLQINQSIIFCNSVNRVELLAKKITELGYSCFYIHAKMLQDHRNRVFHDFRNGACRNLVCTDLFTRGIDIQAVNVVINFDFPKNSETYLHRVGRSGRFGHLGLAVNLITYEDRFNLYRIEQELGTEIKQIPPHIDQAIYCR
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
IVRQGEPQAPAKRAGGAEQTVAKKKKKRKADKRKRSEPKTAADNPSNDETPVQEEDQKDMSAWLNCYVPEPVLKALAELNFTQPTPIQAQTLPSAIRDHMDVMGAAETGSGKTLAFGIPILHHIAEQKARIGDGPMSLQALVLTPTRELAIQVKQHLQSAAKYTGIGVVNVIGGLSADKQLRLLKRRPEIVVATPGRLWELVDQNTPHLSDVSNVRYLVIDEADRMVEKGHFEDLTRLLALMNADRVDGAKRRQNFVFSATLTMQLMRIIGVSAKPKVVDLTRKLGTAESLRESRIVCSSIEDKDSRLYYFLLAHPGRTLVFCNSIDSVRRLVSVLDLLQCSPLPLHAQMQQRQRLKNLDRFRSSPTGLLLATDVAARGLDIEGIEHVIHFQVPRTAEVYVHRSGRTARAASDGLSVMLMEPRELPVYRKICRTLGREEDLPDFPVDSDVLKAVLDRVSLARR
The following text describes a protein:
Function:
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MHACEGDAVTKLTNEKIPYFNAPIYLQNKTQIGKVDEIFGPINESLFSIKMMEGIIATSYSAGDKFYIDPAKLLPLARFLPQPKGQQQASRGGGRGGGRGGRGGRGGGGFRGGRGGGGGFRGGRGPPRGGRGGGFRGRGRF
The following text describes a protein:
Function:
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MKWFEGQISNAVAQARQQRSVFMVYIRGSNEDSEKMDATWEEETVDKSCQEAGIVVLRLQADSEECKQFSVYYPVICVPCVYLIAGETGVLIESIAGFATSSDLVQKIKKVHETMKQAQSASPPAEQPATAPQVAAVTPVQPSSTPEVSSAAASSSSSGSQKESAQERAARMRQKMEEVHRKKEQQRKEAEKQKELERRKVGQEIQKADQGRTELQARKAADDLRKERLDDKLAREKVLQQLARDKAEKEARFRTEKEKREQQKMQAQKEKEETLKATQAQKEAAKLDTAMIQFRLPDGSTMTNQFDSKAPLQEAQDYIKQNVGAALPEFTLSVTYPRRNFGPNDMQTTFLDLGLAPRAAIVVLPGRLTPTTSGQSRSQVSASSDGGLVSWVLAPFLFVYNIIYNVIFGSPESTSSPQPSPSPSQSPVGPESPAGDRSSRGAGARPKSSYARRRTPASGSNADNFSRQEGNVHRLNTQQEDDDENNTWNGNSTQQM
The following text describes a protein:
Function:
Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing.
Subcellular Localization:
Golgi apparatus.
Sequence:
MTIWHGGNMALWLVPRTTGDHDLVSAIRRESSVLRERNAGRCSDEFGIHATLLAGLGDRSIGVNGLKQAVQQAVEQWKHVHHKSSLTVPLQSVTTKASYFQCILIALSATPALTSLNHITSRIVNQSFPPPSPDPSEPYFPHISLLYADLSQSEAQSQILQMQQQHVFKTLDHNPSHPHISFRGFTHVEFDSIHLYDCTGTPQQWKHLHTIPL
The following text describes a protein:
Function:
Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
Subcellular Localization:
Cytoplasm. Mitochondrion intermembrane space.
Sequence:
MSSLSAASCDSTKDATEPQEKKPLKPCCACPETKKARDACIMEKGEEGCKDLIEAHKDCMRALGFKI
The following text describes a protein:
Function:
Histone H3 and H4 specific chaperone component of the nuclear histone acetyltransferase B (HAT-B) complex. Involved in chromatin assembly and telomere silencing.
Miscellaneous:
MISCELLANEOUS: Present with 4550 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The N-terminal TPR repeat region contains an acidic patch that is important for interaction with histones. A C-terminal, highly polar region mediates interaction with dimeric histone H2A and H2B, but is not involved in interaction with heterotetrameric histone H3 and H4.
Sequence:
MKLRAEDVLANGTSRHKVQIDMERQVQIAKDLLAQKKFLEAAKRCQQTLDSLPKDGLLPDPELFTIFAQAVYNMEVQNSGNLFGDALLAGDDGSGSESESEPESDVSNGEEGNENGQTEIPNSRMFQFDQEEEDLTGDVDSGDSEDSGEGSEEEEENVEKEEERLALHELANFSPANEHDDEIEDVSQLRKSGFHIYFENDLYENALDLLAQALMLLGRPTADGQSLTENSRLRIGDVYILMGDIEREAEMFSRAIHHYLKALGYYKTLKPAEQVTEKVIQAEFLVCDALRWVDQVPAKDKLKRFKHAKALLEKHMTTRPKDSELQQARLAQIQDDIDEVQENQQHGSKRPLSQPTTSIGFPALEKPLGDFNDLSQLVKKKPRRH
The following text describes a protein:
Function:
Essential for the assembly of the mitochondrial F1-F0 complex.
Miscellaneous:
MISCELLANEOUS: Mutations in ATP10 induce a loss of rutamycin sensitivity of mitochondrial ATPase; MISCELLANEOUS: Present with 1890 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MQGTFKRFYHPTLTRMSFLDKFLKPMMATASPKEYQIKQLVKPIGLTQAPRKSTKYSQGNSLRDMFDSEKTNHRVKELAVEFSKSGLYDVQVFQKTKGKLFIAPVSYWKEDKALFFPHLIGTAMDGTKQQNIEDMLRGKTSIVRLFSTASGDKLSSSYFQGIVDDNKKTDYLTEADARLSLNDSNVQIIEVNLVENAVKSALVKTLARWANRVPSWRQPFYFECSRGQWPFSVREELFCNNVFSGYVFLVDQQLKIRWAACGEATPSEKEALWKFAKRL
The following text describes a protein:
Function:
Required for efficient biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDVDGDKAARLTSRYDRLISALGEDASSGVCARVEDASAAVEVAESGEQRQKLLAAATAKSVRCAELIAKSLEASAALSQLQRTLKDAYERSQEDADESMNTEEDEQEDEATTLLLQDLVAAGDDAEDATKKYARLGVVRKTARASHELLASAEHHLQEHLGSLSTTAGDAAVQNEFRDLYMEEFTTAFGDELDQFRQEERFESKDVTYLISCIHSGGDIFSPLQKKLFIESVGASRASE
The following text describes a protein:
Function:
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
Subcellular Localization:
Nucleus speckle. Cytoplasm. Nucleus.
Sequence:
PMNAFMVWSCGERRKLAQQNPSMQNTQISKQLEYGWKSLTEAEKRTLFQEAQRLKTL
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MCVCVCVCVWAVSPVRWSVRRFSCCTMQVPRWLIVLQSVVLKFLFAILPLSFDRHRERFRNRTKDVILSTVLLVLYAIVGPIVCVELYVMNISVENQITNALSAFQFAFVYFFILIVQIIFIRKKACLHVLLNEMFQLKHVLERMVARSMLEFRLYRLFLVKVTAVDILMQLLALYTFEDSTYTGRVDSVGLASWLTFYAMMYFIAVIENFILAGVLIGAVMQAMVNIGLKRLARSRQGSAAGRQPSVLQLYMLHCKNEDMVKQFMETLNFPTLMLTGWYFFMIVYSVRPPASPVGNGIADDFKAYINPLIFFLYQCVQLYLLVLIPSVYTDHAKKMMRLLNYVSVNQHHHRPGQERLVGREGGVIEVLMVDCMQRNNAINNYGMYAMNRALLFGMIATMTSYLIILIQFHIQAYE
The following text describes a protein:
Function:
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVQIWQMEPYPCGDPRLPHHLFPPKKITPDELSKRTGTLYWKLDTLDQVALAKRLTTLKLEHNFKKEDIFTLDAETTANFDDKIEELFEESSVPFEQARMIIEGSAYYDVEDKNGQWVRIFCEYGDLILIPSNTCFRFTTTPKNFVKMRRFYKEEEGN
The following text describes a protein:
Function:
Has bactericidal activity.
Subcellular Localization:
Secreted.
Sequence:
MRTLCSLLLICCLLFSYTTPAVGSLKSIGYEAELDHCHTNGGYCVRAICPPSARRPGSCFPEKNPCCKYMK
The following text describes a protein:
Function:
Cytochrome P450 involved in the biosynthesis of etoposide, a chemotherapeutic compound of the topoisomerase inhibitor family. Catalyzes the conversion of matairesinol to pluviatolide.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MEMEMSVLAMSSTLILALAMALIFLFKAKSSSAIKWPPGPKTLPIIGNLHQLGGDELHIVLAKLARVHGAIMTIWMAKKPVIVVSDVNSVWEVLVSKSSDYAARDAAEISKIVSASSHSINTSDSGPYWQTLRRGLTHGPLGPLNISAQIPIQQRDMQRVIREMQQDAAANGGIIKPLDHLKRSSTRLVSRLIFGDTFDNDPYNDSMHEVVQDLNRFGGIALLEQAFSFAKHLPSYKRGVKEFHIHKRKIDDLVRPVVASANPPSNSYLGFLQSQNYSEEIIIACIFELYLLAMDSSASTATWALAFMIRDQQVQEKLYQDIKRVIGDGVDLVKAEDLSKMHYLQAVVKETMRMKPIAPLAIPHKTAIDTTVMGTKVPKGTCVMVNLYALHHDESVWAKPYTFMPERFLQGEDGKSVTEQAFLPFGAGMRICGGMEVGKLQFSLALANLVNAFKWTSAAEGKLPDMSDELQFITVMKTPLEARIIPRNP
The following text describes a protein:
Function:
Involved in nuclear export, actin cytoskeleton organization and vesicular transport.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPTDTKRKAHDQEPTADSSDYDSDGSEEPDFINVDFDFRAPEEIDFQALKRLLQQLFYTHNTKLDLSSLADHVVKTSTTQGVGTTIKIVDDEDQDPYAFVSAITLSSEKKEGSEAANSLSKYLLEVTSKPSSKSVHDVIKSAASSTSTNAPVIAVLHERMVNMPPQVAPPLYKMLLEEVQASLVSTSATRPSHYLFFSRVFSADAFSDDEAMDEDDDDDDDEPSGLAGARKRKAKLARREAKKAGAKKDAPKSRTISDGMALAGSSDEELGLFHPEDIAISKFASNSLTYRFPPPPDASDSFEAPLFGRIALVPADKMDALLQQIETDLSMPAPQ
The following text describes a protein:
Function:
Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
Sequence:
MDCVSSVLPNGIHLKLMKGPRGVCSIGAVFPIGSINSPKTADTQVTLSSKLVESLISPKHVFMHQVYPFLQVNREYSYLTLQFLPESTTYAIESLKRFLDGAAPANTTFDQQKQLNYAAEQLGEYNLLEKYKDLVCMSSFSNKSYAHGNYALQGEKIDLNPQILKEIPKCTTLVGSIDMYEELVKLGGSLSPFPKVKLHITSNFEPNHVNKNVKQSSLQGSKISMTSSLSIMSLSWPSCEAKSVEAPAYAVLSKIFGGGSEFSSEGLGSGFSSLLYTKVVGGVARCHQAYAYNNFFTTGGRFNINVVAEDRNLVKAAQLVRECIHSVETIEDKNLDAARGLVITAGTKELNASDKRFNEFVRSSYLGCKPIYSSQYKKSIKEVTRKAVEKALKQTFSYKPAVAVYGPAVPNEIAKVFE
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
Subcellular Localization:
Cytoplasm.
Sequence:
MTRSPAPSSPTHPRRLGLTGSIGAGKSTVARLLRERGLTVLDADAEARWVTEQPEVLTELNEAFPGVVTGGTLDRAGLAARVFSDPAQVARLNAITHPRVRARMEALEAAATARGEHWVVQDIPLLFEGGLERGMDAVLVVDAPLELRLERALARGGLTREDILARDARQLSSEEKRRRATIVLDNSGPLEALEGQLDAALRQLEIT
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MQPCKESQSQPTLKNRIFNLLSRSEPRVKRATHSSLPTKRDRTERRVSSTSTNQNTSKPDEQRQPKMAAITLRLIGAIYLFRLLNALLCRTYFQPDEYYQSLEIAHRLVFGYGYQSWEWRPLPDGSTGGIRSPLHPFLFVPLYWLLRILRLDHTRLIIILPKVLQAGIATVTDLATYSLASVLLTPSYAAAALACSLTSLFNAYAGIRTFSNSLETALTASALAYWPWNPAQISSSWANLSFSILLIALSVIIRPSSILFWSLLGYTLLQKSNGETRMDVMAIVAVMGVISALACFLIDSSFYGVATFTPLNFVRQNLLNDISSFYGVNRLHFYFTQAFTFVNFSMFPTVILGMNMLATPQNDHESRGQLDRLRSARVAVLGTMLGLSVLRHKEFRFIEPLLPLFNCFAARAMVNNYIKDRLARPATSPADVSPLERILSARPLGFILRSSISLLAAVYLLGFHYRAQVSVIDYLREVPDLQLKSVGFLTPCHSTPWQSHLHKPHLAPNGTQERLWMLNCEPPLVSFQNSSLSEADSTANTTTYQNATESDEDSERKRETIATTKQMNETREYEDEASEFYGDPTGFLRARFPGTVDRGYPATDKSLQSYQWPSHLVLFEALWNHTSVRELLQTLGYQVVWNQTNGWWHDDPQRRAGSVIVLRSV
The following text describes a protein:
Function:
Phosphomevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). Erg8 converts 5-phosphomevalonate to 5-diphosphomevalonate (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase erg12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase erg8. The diphosphomevalonate decarboxylase mvd1 then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase idi1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase fps1 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).
Subcellular Localization:
Cytoplasm. Mitochondrion. Nucleus.
Sequence:
MKVTCSAPGKVLIAGGYIVLDPQYSGLVIGLTAKGYASTTTLDDKCGTVRVKSPQFINAEWLYNIDWTVSPIRVHQIYENCELEKNPNPFVQLALFYVINYFFSTGRQPLCWQDLQVTLQVDNAYYHQPQLKPDQTSYPKFNFLNCTLGQVHKTGLGSSAAMITSLIGSLFLSLRRLTDDTGDKSLKIDDSTKVIVHNLAQIAHCSAQGKVGSGFDVGAATWGSCIYRRFDPKLIEQLLVPYDEQIKNINFSTELRKIVSKKWSDVVPFQLPATYCLLMGDVAGGSSTPGMVKKVQQWQKENPEESKNCFDDLYSRVLSIKNCFLSSESLDSELQSQFRSIRRILQRITVEAKVDIEPLKQTNILDNIEQLPGVIGVGVPGAGGFDAQFCLAINHTEIIENVIKTWKDDGVVPMDVSPAFDGLAVE
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane; Single-pass membrane protein.
Sequence:
MATQSSDPPPPSNPADQNPGNVQPTNGIQQDAEVEAIKQSPPSVFVNSEPMREEQVQNAVKFLSHPKVRGSPVMYRRSFLEKKGLTKEEIDEAFLRVPDPTPSTQATSLNQAEGQVKSTPNAQPLASAQTLQPVAAGPTAVISSVGTLTRSRFHWYHAVFAVGLLAVSGAGTVVLVKNTVIPRLKSWIRKVVLEEEDDNVKKTNLKPSLAEEAAAAAKSAAAAAVDVARASQELLNSKNEEKRYFKEFMKMLDVQVQEMKSMSTAIHRLEGQTDNRVRNSLADQEDYRALVANPKQTYTNGKTEFDLHSGGSSSQPASAEPSAAPHPKSYMEIMEMVRRGERPGNIRPWEVGQVQNNSSQVLQSQVSGEDLNSKVQDNGIYQFDGESTTPWWQQKNAGIAEIDNEDEVKAGRYGGQNNQQPVRRTWVPPRPPPVVMAEAAEAIRRPKQSIQKEQLEDDRSVSHPTDTADELQRITKISESGGAVEINGGGSVLNSSEIQEEPEQIHEGN