lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.
Sequence:
MASPPERTVAALESCFRALPADAVPAVVDCVLASSASTSPAQLFHALLRSPASSEVGWLWLFAAALFYPISIHIQRIYGSSFPPKQQQQGLQAQSDRHASISHAAALRHLLARFDNRPKAKDAMRLLLWRVFLPLLRDTIEPNLHQVVAFMCDAISDTGSWDLLGATIVPFCIRSSVVAMGLSAGHDSMLYHSITEADFAGDSLAPMLTLSKASSVLASLLRDILERRRTVLSVGPLNSQEVAVDLDALVQNLTWDLSTLVFKMFAHGQEYRSCATRTLLQPLLISLADIPCVTVMLGAVQHKLSRFGFLERIWDSCISLFSLGRGERLDAYNVLSLYLSTLKLGHQVAILGADKLQEFDLSNVSEFWNQLRKGLVDKDSFVRKQAFYVLTISLSIFTSSSLNDGNHHCSSKRLAALPAQTKSNTATTKRERWASKEAKSLGVRQTDQSDERCSNGQGRWKVFLLLYEMLQEYGTHLVEAAWMHQVMLLFESTPQTDYLNHTSHGAFHAQMESWEGILHWMTVLWERGFTHDNPQVRCLVMQSFLDISWEHYKVCAQIIPRGFVLGSLIRGLNDVVHHKDFGVVGIYDSKTIKGAESFFSTYAQNLTRRDRIHLVWSLASAAKHDSFGRAGLMTLASCVASCTCQSDINDVPCATPWKEPSKCDGDVPTEVRSEDLLDALWILSERSKQHFNPKYRLKVCEQVIKVATSLINAAEVPLNQLLHFISTIPREFTDYFGPLRVIVQEWFVQKKECSPGNTLLSKLLDFPTTFVKHSKQDQGSNLFDDEDVNAWEAEARRWARTLLLVTSDEQHLKRILGFIEAHGYKLSQQSPVGDCVPIKFFIILLSFIEELEARQKKLETMVVFSKLSCSVFWLKNIENMDLPYSVKGKLGGPSQRRLATSITSSVLQGIWSMRCISSVASWCNHYNSGDSFFPTFSFLWDFYWKVIEHSTNATETGAELHLAAYEALAYVLEALSTARNSQYLDLVETEQTNQARKFSLDISVTTFLNNINRLLTDGILTRSRRAVLMTWKTMMQLAKSSWILHLSCNKRRVAPIAALLSAILHPAIFCKLEMHQTNEEGPGPLKWFIENLLNEGSKSPRTIRLAALHLSGLWLMYPETLRFYMDELKQLSLYGSVAFDEDFEAELSENHEAKFEVSMLAQSPDREFTEVFINTELYARVSVAVLFHQLWKQIKEKNISGTEEALQSGKLFLLKLLDSAVNDKDLSKELYKKYSSVHRRKVRVWQMICVLSHYVEDDIVGEVILSTHTCLYRNNLPAVRQYLETFAILLYLKFPTLAKEQLIPIFHDKGMRQQALSSYVFIVANVILHSRQLSVQRNHLNQLLPPILPFLTSHHHSLRCFTQLLVHSVLSRLWPTLYLETSEDVIFERRCFQELKDYLAENSDCVRLRVSIEGFLDVFDPNASGTPSGIFSTRPEVSEFECVPVSVMERVIEFLNDVREDLRHAMAKDTVTIKNEGLAVEGHGDEDKSGEKVSVLLQPGCQDALDFQKKITPRRDSEQALNLNARDHSRLISGMQTVPCCSFLSPTYIVTCLSPVLIAEIEEDDQLFNLALEARLHAAETIKQSQQELIVVASLVDRIPNLAGLTRTCEVFRAAGLVVADKSILLDKQFQLISVTAEKWLPITELPVDSVKAYLERKRAQGYSVIGLEQTAHSRPLDRFEFPRRTVLVLGREKEGIPVDIIHILDACVEIPQLGVVRSLNVHVSGAIAVWEYTRQHSQQPRPSSGVLTLLNADATS
The following text describes a protein:
Function:
May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Associated with microtubules.
Sequence:
MEGGGGRDEPSACRAGDVNMDDPKKEDILLLADEKFDFDLSLSSSSANEDDEVFFGPFGHKERCIAASLELNNPVPEQPPLPTSESPFAWSPLAGEKFVEVYKEAHLLALHIESSSRNQAAQAAKPEDPRSQGVERFIQESKLKINLFEKEKEMKKSPTSLKRETYYLSDSPLLGPPVGEPRLLASSPALPSSGAQARLTRAPGPPHSAHALPRESCTAHAASQAATQRKPGTKLLLPRAASVRGRSIPGAAEKPKKEIPASPSRTKIPAEKESHRDVLPDKPAPGAVNVPAAGSHLGQGKRAIPVPNKLGLKKTLLKAPGSTSNLARKSSSGPVWSGASSACTSPAVGKAKSSEFASIPANSSRPLSNISKSGRMGPAMLRPALPAGPVGASSWQAKRVDVSELAAEQLTAPPSASPTQPQTPEGGGQWLNSSCAWSESSQLNKTRSIRRRDSCLNSKTKVMPTPTNQFKIPKFSIGDSPDSSTPKLSRAQRPQSCTSVGRVTVHSTPVRRSSGPAPQSLLSAWRVSALPTPASRRCSGLPPMTPKTMPRAVGSPLCVPARRRSSEPRKNSAMRTEPTRESNRKTDSRLVDVSPDRGSPPSRVPQALNFSPEESDSTFSKSTATEVAREEAKPGGDAAPSEALLVDIKLEPLAVTPDAASQPLIDLPLIDFCDTPEAHVAVGSESRPLIDLMTNTPDMNKNVAKPSPVVGQLIDLSSPLIQLSPEADKENVDSPLLKF
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
Subcellular Localization:
Mitochondrion.
Sequence:
MLSRSSLSLATSSRLARWACATSTSTRNTTATTLQIPTACSITRCLATSVSVASGREASSPASNRNQDRSDYRPRRRDEDVRSNHRSGGPNHGVPVAQYSRNQRFAADGTRKRLPHPNAKPRSDREGDRNQSANDQRSSRPRDGPSRFKKAGEAGYSSWRNKDDSALKFGYTAQDGMGSNSASNAATKRDSTVSRLRARNNTPLDDADDRGFRNTEADRFGDATSIEDDASARSPRGVAVDDGILKGNSILERSDRHHTAKQKKKEGRGSLLDPEHDHDHNPSSRSWPTSSSNRQPRHASVSPDNMHASRLDRAPTPRVKPKLLPKVERNIFLPSVISVVMLATRMEKKLRAVQNVMSELGMEDTRPDLMLKFEDAEMIAAQLNVVAIPNDEASFDIYPRPPPSTPEEAASLPRRPPVVTIMGHVDHGKTTLLDKLRSTSVAQGEAGGITQHIGAFSVPISGREQLKGKRKGYQGIQTITFLDTPGHAAFTAMRSRGAMVTDIVVLVVAADDGVMPQTREVIQLVKDANADMDSNDIASSQPHVQMVVALNKIDKPDADPERVKRQLVAAGVELEELGGDVPCVHVSGKTGRGLDDLEETVAILGELAELRAERTGLPQGYVIESKVDKGRGNVATVLIKRGVLSKASPIIAGTAWCKVRQILHSSGRPLANAFPGDPVLVTGWRELPSAGDMLLGATDEQSCKRACENRKQLQEHKKMMQDVEQINEARRAKAEQEEAEAKKEFEDRQRRRAARLAADDGKDPLAVLAAMEAASSGATGETVQVDQDADGVEIAESKDSTTSAGQGKKLLNVIIKADFSGTVEAVVGAISSIGNNEAGVKIVSASVGEPSESDVAKAAALSATIIGFNVTPSKSVLQSAARAQPDPVPVIVSDVIYRLMETVSARVSTLLAPLTEARVHGEATVSQIFDINLKGKTFKKIAGCKVTNGTISKSNAVKVLRGAERKEVYRGKLDQLKHVKKDVAEMRKGTECGMSFEGWQDLKEGDVVQCFSEVEVARSL
The following text describes a protein:
Function:
Involved in ribosomal large subunit assembly.
Subcellular Localization:
Nucleus.
Sequence:
MTSTVVNKVVDPLVDCGRLLLIDRDPITEFGNEDELITRARNNVQFLFNKVWELDKKRVEDSIVAVLPKPSFKLPREKPIPEKRAATRWEEYAKLKGIAPRKHRNKKVYDEESGEWKPRYGYRSKDNTKEWCIEVPENRGEDADMFAEKREAKKERVAKNETQRLKNMARNLQASCYALFATFLIIFTKNKKKAAIPPEDIARVGLAKEADERTKHDIRVTVDRTRASTASLGKFQKKIHGEKENVKTGKKRQFAPNIQPVSGEKEQAKEVLKHLLTKKPRLLDHTMTTVAAGPAEKEEAPLDASRRKKGGERIRQKNSIHKASYFKNAVKGKNAPQKGNKKGGKGKGRRE
The following text describes a protein:
Function:
Broad-complex proteins are required for puffing and transcription of salivary gland late genes during metamorphosis.
Subcellular Localization:
Nucleus.
Sequence:
MDDTQHFCLRWNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTPCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAEDTHSHLAQIQNLANSGGRTPLNTHTQSLPHPHHGSLHDDGGSSTLFSRQGAGSPPPTAVPSLPSHINNQLLKRMAMMHRSSAAAAAEETSHAFKRLRGSDNSLPLSGAVGSGSNNNSPDLPPLHARSASPQQTPADFSTIKHHNNNNTPPLKEEKRNGPTGNGNSGNGNGNGNGASNGNGISISDKLGSLTPSPLARAGADDVKSEPMDMVCSNNNANANDEHSNDSTGEHDANRSSSGDGGKGSLSSGNDEEIGDGLASHHAAPQFIMSPAENKMFHAAAFNFPNIDPSALLGLNTQLQQSGDLAVSPQGKLTTNATTTTTTINNSITNNNNNNNNNNYDYSLPTKNSNSQKTPSPTTTTLTTPTTTTPTRPTAITSASGICGLNLSTFAANGSSSGGSNGGLSMTALLPQQQQQQQQQHQMSQQQQQQQQQQQQQGNSSSGQQQQPNGILACSTPKANTPTTTQQQMYAAVMAAAASASASTSGSANSSLNNSNSTLNTSGGLNNSASGGDDFRCNPCNKNLSSLTRLKRHIQNVHMRPTKEPVCNICKRVYSSLNSLRNHKSIYHRNLKQPKQEPGVGATQAAANSFYHQQHQQQQLNHHSSS
The following text describes a protein:
Function:
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Sequence:
MSLNIETKKVAVEEISAAIANAQTLVVAEYRGISVSSMTELRANARKEGVYLRVLKNTLARRAVQGTSFAELADQMVGPLVYAASEDAVAAAKVLHQFAKKDDKIVVKAGSYNGEVMNAAQVAELASIPSREELLSKLLFVMQAPVSGFARGLAALAEKKAGEEAA
The following text describes a protein:
Function:
Catalyzes the 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp-B) to cis-4-hydroxy-D-proline betaine (cHyp-B). Is involved in a catabolic pathway that degrades tHyp-B to alpha-ketoglutarate. This pathway would permit the utilization of tHyp-B as a carbon and nitrogen source in the absence of osmotic stress, since tHyp-B functions as an osmolyte and is not catabolized when it is needed as osmoprotectant. To a lesser extent, can also catalyze the racemization of L-proline betaine.
Sequence:
MKIAEIQLFQHDLPVVNGPYRIASGDVWSLTTTIVKIIAEDGTIGWGETCPVGPTYAEAHAGGALAALEVLASGLAGAEALPLPLHTRMDSLLCGHNYAKSALDIAVHDLWGKRLGVPVHELLGGALTDSVSSYYSLGVMEPDEAARQALEKQREGYSRLQVKLGARPIEIDIEAIRKVWEAVRGTGIALAADGNRGWTTRDALRFSRECPDIPFVMEQPCNSFEDLEAIRPLCHHALYMDEDGTSLNTVITAAATSLVDGFGMKVSRIGGLQHMRAFRDFCAARNLPHTCDDAWGGDIVSAACTHIASTVLPRLMEGAWLAQPYVAEHYDAENGVRIEGGRIRVPQGPGLGLTIDPERFGPPLFSA
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Sequence:
MAMAAISSTTCTAAPSSTLRLSSNGSGLRSAFAGPQCSCGGFSSALFGAPILRVQRLSGTPRQRGPVQISAVKYEYKSSQNTNDLSQAPLSSGNSNLTLIKDARIEAQPQDMKLKLRVDLTGQSTQKAFDTIVRSLAKNAPPVPGFRKAKGGKTSIVPTSVLLNMMGVSRVRKFVIEEIVRTVLVEYVEQEGIKAKKNLATDKTADELNAIFEPGQEFGFDATLELEDDSADEVAKPEAADASEIEVVGA
The following text describes a protein:
Function:
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. This enzyme is essential for viability.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.
Sequence:
MTLTLNRQLLTSRQILVAFSGGLDSTVLLHQLVQWRTENPGVALRAIHVHHGLSANADAWVTHCENVCQQWQVPLVVERVQLAQEGLGIEAQARQARYQAFARTLLPGEVLVTAQHLDDQCETFLLALKRGSGPAGLSAMAEVSEFAGTRLIRPLLARTRGELVQWARQYDLRWIEDESNQDDSYDRNFLRLRVVPLLQQRWPHFAEATARSAALCAEQESLLDELLADDLAHCQSPQGTLQIVPMLAMSDARRAAIIRRWLAGQNAPMPSRDALVRIWQEVALAREDASPCLRLGAFEIRRYQSQLWWIKSVTGQSENIVPWQTWLQPLELPAGLGSVQLNAGGDIRPPRADEAVSVRFKAPGLLHIVGRNGGRKLKKIWQELGVPPWLRDTTPLLFYGETLIAAAGVFVTQEGVAEGENGVSFVWQKTLS
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B (By similarity). H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (By similarity). Involved in regulating stem cell proliferative fate.
Subcellular Localization:
Nucleus.
Sequence:
MMKRSNEGIGGENYASSPSDDGQQKRRKIQFEPVRMPAVSNVNDIRARAVVYQTSKLKQQLLYKNKRIAELEKENERSKRRQQTDESNFLKVYNMFSDIEKYICTQTKNEFGEYIGGDTAPTGIDVLGMTNETYNKFFDQAKQNLRNAFVSYAKARHDRAHESTIFIDKLKTLIDSPTFNPNGVHKELTAKAASLAIQNEKLQSEVTKVQSDCYNLERKKRILTDKLSVQENRVQELEHQLEDARFETDKHMRLANKFEYKLATLVSEGQSGGNGGATPSSSGTTNATEKKISAPDIPPSETAAKEIENLRLERDEQESIASRRLQDLEEMNKKVQTLTQENSKLRLETQTFFSVDSIVNSEEYKNLKKYYSLAIKEYERVSKDLEDITTERDAFRSAKEARAMLMSEEHQKTLKEIQCQSDIHNSFYKVSHDSEVLRCEFETVKEEYNKTVKQSEWDEMKATLNTLRSMNRSLKSEKIRLREKDKQSQKDINTLKSELTSLKEAQDKCLLVPLEDVSNAPPEDVNKIRQEYESLCKEVKRLGAMEKQEKQKQVENLQKEVNRQIADKLSELETLRKTNEMLTNDEECISDELEAIGTAVEEEQERNAQLYIEKREQEDRNLKMMNDRMIQNQTFNRLREKLSCLESKAQTDAQIAKMHEFEKKANEELVTKLSESVQFKSAELTRLTNLMEQHRKNIQEVGMSRDENQIKADRCEGQMKQIQELYAAKAREIEDFKFKRQRAEEELETLRIKYERVKRNESVPAQSGDQVLEEANRQMKETLTCPSCKTRPKDCIMLKCYHLFCETCIKTMYDTRQRKCPKCNSNFGANDFHRIFI
The following text describes a protein:
Function:
Involved in the protein transport to the vacuole, probably at the level of vesicle fusion at the trans-Golgi network (TGN) and not in transport from the TGN to the prevacuolar compartment, by promoting the recycling of vacuolar sorting receptors back to the TGN. Involved in early endosomal vesicle trafficking, particularly at the trans-Golgi-network/early endosome (TGN/EE) thus residing in early endocytic route. Together with BIG5/BEN1 required for polar PIN-FORMED (PIN) proteins localization, for their dynamic repolarization, and consequently for auxin activity gradient formation and auxin-related developmental processes (e.g. embryonic patterning, organogenesis and vasculature venation patterning). Necessary for pollen germination and for cell expansion. Binds syntaxins.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Early endosome. Note=Binds to trans-Golgi network membranes through interaction with other proteins.
Sequence:
MVLVTSVRDYINRMLQDISGMKVLILDSETVSNVSIVYSQSELLQKEVFLVEMIDSISVSKESMSHLKAVYFIRPTSDNIQKLRYQLANPRFGEYHLFFSNLLKDTQIHILADSDEQEVVQQVQEYYADFVSGDPYHFTLNMASNHLYMIPAVVDPSGLQRFSDRVVDGIAAVFLALKRRPVIRYQRTSDTAKRIAHETAKLMYQHESALFDFRRTESSPLLLVIDRRDDPVTPLLNQWTYQAMVHELIGLQDNKVDLKSIGSLPKDQQVEVVLSSEQDAFFKSNMYENFGDIGMNIKRMVDDFQQVAKSNQNIQTVEDMARFVDNYPEYKKMQGNVSKHVTLVTEMSKLVEARKLMTVSQTEQDLACNGGQGAAYEAVTDLLNNESVSDIDRLRLVMLYALRYEKENPVQLMQLFNKLASRSPKYKPGLVQFLLKQAGVEKRTGDLFGNRDLLNIARNMARGLKGVENVYTQHQPLLFQTMESITRGRLRDVDYPFVGDHFQQGRPQEVVIFMVGGTTYEESRSVALQNATNSGVRFILGGTAVLNSKRFLKDLEEAQRISRSGSHMV
The following text describes a protein:
Function:
Probable transcription factor. May regulate some genes of ciliated sensory neurons. May activate the expression of the shared components of sensory cilia, but not the cell-type-specific expression. Together with transcription factor atf-7, involved in regulation of the serotonergic response of ADF neurons to pathogenic food; [Isoform c]: Involved in male mating behavior; may play a role in functional specialization of PKD ciliated sensory neurons.
Subcellular Localization:
Nucleus; [Isoform c]: Nucleus.
Sequence:
MTNEEPVPSTSSVLSAAEKNVKIETPSRKRKGLDIDALWRKKFKDVENQKSPEKSEKSEKTIKEEPLETHPSGERKLRSASKDSKSLSKETHNTISTRSSSSGTPRKKMEPEDVKPNIKMLKKSLPVSFQCSNLNDGTVGDASVMLDPTKISLHSSSVAYGEESQDEMEVIQHSTDDPNGTREEFDYNQIEYGNAVTPNGTYTLYAPDSNYAPYYQYSNNMQSSPQDNAPYLVPAPQSPVSIDDADSINLPNNQRASPATVNWLFENYEIGEGSLPRCELYDHYKKHCAEHRMDPVNAASFGKLIRSVFHNLKTRRLGTRGNSKYHYYGIRLKDSSTLHSMQHPQPQIIQNTYTPPMQLPQRDAYADTVNQVAAIKYMDVEIPDKRARKDNSSSSSSCRDSVSPCMDLPAQQTIQHTPVHSVIPSTQQPAPLHNNNVVSYVVTESDKAAMGKIDLPIVPFPDKDALMATIGFRKLGVGEEELNSLIDIYEILCREILALIKNIDFASVEDTWSKFWSGNFGVDRDHISALCTLDQVQDYIIEVDLALYQTIVDTLIPNVLLSELSTGMTQTCRTFAKNIDVYLRKSLMLANLGEFFVKKKIQAIKYLQQGLKRYTSLNHLAHASRGVLMKPEQVQQMYQDYIRVDINTVHQQAGWICGCDSVMVHHVNNAFKHNLQRMSAMEVWAEWLESIVDQVLAKYHDKPANVIANVGKQFLLNWSFYTSMIIRDLTLRSAMSFGSFTLIRLLADDYMYYLIESKIAKAGKQQLITVIRADKDWPLTTNPQEYIVVANDNDEDLDLEKAGLL
The following text describes a protein:
Function:
Required for pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MEIQTSGKPIDSLLEKVLSMNILSSDYFKELYRLKTYHEVIDEIYNQVDHVEPWMTGNCRGPSTAFCLLYKFFTMKLTVKQMHGLLKHPDSPYIRAIGFLYLRYVADPKTLWTWYEPYIKDDEEFSPGSNGRLTTMGVYVRDLLLGQVIHFGKCPTCSYEILGLHFLMEYSLRDQYITSLSTIKFKYYFDTLFPRVPVPVVRQIVANLEKLKLPTKHCGVTGETSRQGSDDIARRPPSVKAALSVSFGQRAPHRASTRDSSPVRRNLGPIHERSDGDDHRRSSPSIRRSSSRDRHDRDRSDRDRDHDRDHRDRDRRDHHRDRDHSERDRGRDSERRHEHERRGDRDRDSHRSKHSERDSGRRDHERSGRDADEYRHSNSRRSRSRSRSRSRSIHTRGADRPSPFGDENKEKTKAVSSNLAKLKDLYGDGSDKKSNEAADRLRKDTSTEEVIRLGGSTWR
The following text describes a protein:
Function:
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MSAATTAYPRTFSSQFSDASSYDAMEGADNLRTRQRRDSAIMDDRAKTSQSNYADTVEKLNTYYQLVKKQIMCHQHLVSGLFPRDTSDPTCNVTHIRDNIYCAAAMWALSQAYKRIDDDQGRTKELLLTAVKTMRGILECWMYQADKVELFKKTQSSKNSLHVLFDSSTQGTVTGDEEYEHLQLDCLALYLIFLVQMTQSGCYIIWCIDEVNFIQNLVFYIERAYRTPDFGVWERGSKYNNGSVELHASSIGTAKAALEAINGMNLYGNQGSNWSVIFIDIDAHYRNRIIFDTILPRESASEEQLVQRTLDKALRKLKGRYGLKRFLRDGYGTVLEEKGKKYKTSDVKQFDGIECEWPMFYCYLAIDSVYKGDMDKAHEYMDLLKPLLIDGMSGPLVPKYYYVPQYSINEERLRPGSQDRLPSAKGNINEATKKDNIFFWGQSVYIIARMLVDGLISKHDLDQISRRLPASLRPRHNSRYLNFQMMMMKRMMAMKRMMAMKRMMAVDGLINISELDPIRRHLPAAERPKANSRYSSFQRGSAEQSSPVDLVIQVSLIAESVRLQQMLATYGIQTQTPHQVEPIQIWPPSELAKAYEQLGVNEKLGLTGRPPRPIGGLGTAKIFKVFGHLAICTSLLFELGDFYLSQDVEFVTNVIQIYRACGYTFVCYSLLFHISDFYLAQDIEFVIDEVKSDLAFLGKCWKLAGRPTFCMILREENLRGVGARYILDLLAQFKKGDCDGTKIRLGRLQEFIATGCIEHLDFLDIDIANTFCPMTEKDKGMQFKSFTDIPKSLKLEIEEDWTDEAEYHSMHIQDLIMLVKSPLNLFRQAQALRELAKRKGLYELLDEQTIDQRLQKLSHTAATAQLWSVVRYCSSVLGKLVDSLAPSITAILVRGKQLTISVYGQQEHVVDKPITPLEIKEVLYTKLYPVDPSQAVLQQELIINIGTFITTTPELFQGILKIRIGLLVEAMKLDMKYKEKTKDSLYTLSPSAIKKLLFRVLDKRHDSTSYYTHERSIIWNRQLDGCLNRVPRDFFERVWHILERTPSGIKLSGYILPQQPTLSDMTQYELNFSLVVDQMLSKIVEPTYRQLIVETIVIVDTMLTRNPELSFQKPIELDLIFKDALFMFTRDHRDQNVRDSKDLTSEDLALFFDTPPNSAHGTTVYIVRAVMNMLLDGDVRGHVDSQCSIS
The following text describes a protein:
Function:
(Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm.
Subcellular Localization:
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Melanosome membrane; Multi-pass membrane protein.
Sequence:
MADPRAESEPLLGRARGGSGHDWPAGSAACGSVRGDPGAVSRWDLCFDQATVFIEDAIQYRSINHRMDARSMWLYRLYYSNTCQWILSFTIFLILFLAFIETPSSLTSTADVRYRSPPWDPPCGLTESIEGLCLLVFVADVSVKSYLVGWAQFQKNLWLLAYMVVLVVSLMDWIVSLGLVCQEPLRIRRLLRPFFLMQNSSMMKKTLKCIRSSLPEMASVMLLLALHLCVFTMFGMLLFTGEKQDHGQDRERLIYFRNLPEALTSLLVLLTTANNPDVMTPAYSRNRAYAIFFIVFTLIGSLFLMNLLTAIIYNQFRGYLMKSFQTSLFRRRLGARAAYEVLSKTAEGEAHPQRVGVKPQDFLQVLQKVQLDSAHKQAIVEKVCSYGDDLLSADEFQKLFNEFDKRVIKEHPPRPEYGSPFLQSAQFLFSHRYFDYLGNFIALGNLVSVSVFLVMDADVLPEDRDDFVLGILNCVFILYYVLELLLKVFALGLPGYLSYSSNLFDGLLTVVLLVLEISTLAVYRFPHPGWKPEMLGLLSLWDMARLVNMLIVFRFLRIIPSMKLMAVVASTILDLIKNMRAFGGILVVVYYVFAIMGINLFRGVVVAPPGNGSLAPDNSSAPCGSFEQLEYWANNFDDFAAALITLWNVMVVNNWQVFLDAYRRYSGPWSKLYFVLWWLVSSVIWVNLFLALILEHFLHKWDRRTHLQSLAGDQETSYQMSVELLFRDVLEEPTEEELVEKLSHHPHLQLCR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGRPKGDAARSKARPSSSSLAASLLPSGSAAAGLGFGGYVGSSRFESSISNEDSAPLLDLDSEMAQHLQRLSRKDPTTKIKALASLSELVKQKKGKELLPLIPQWTFEYKKLILDYNRDVRRATHEVMANVVAGVGRDLAPHLKSIMGPWWFSQFDLASEVSQAAKSSLQAAFPAQEKRLDALNLCSAEIFAYLEENLKLTPQNLSDKALASDELEEMYQQMISSSLVALATLLDILLHEPDNAGSASLNAESKLATKARRVATSSAEKLFSFHKCFLNFLKSESPSIRSATYSLLSSFIKNVPEVFSEGDVRCLAPALLGVFRENNPICHSSMWEAVLLFFRKFPQSWGNLNVHKSVLNHLWQFLRNRCFGSPLVSYPALILFLEVMPTQSVEADKFFVNFFTNLLAGRSMCDSRADQLSLLRATTECFLWGLRNSSRYCDNPNSIQDLQVALIDKVLVKILWANLFELPKGSTPPIQKKPAETLSMSSSVSFLSELGRCIIEILSGVNLLEQKLLSFFFKYVQESFLNTLQQGNLEIITGSMKKMIDFLLLLERDSVSEAESWPLDQFIRPLLSKAFPWIKSSELIDAVKLLSVSVSIFGPRKIVPSFTGCIETSTLLSDDEGSDMSSEKFIKVFREVLIPWCMDGHDSSTAAKQDLLLSLLDDECFTQQWSDVISYVFDQQHQGFNNLASIEMLLEKARGEITKRSSGLGLNKRIGSRPVDWHHNLIESTAISLVHSSSMTTTSTAQFLCSVLGGSTEDSSISFVSRSSLVLIYRGILERLLSFIKQSPLCSVNDTCSSLIAVAVDIEFDLSSSVDATTVAKFAAEVIDGSIFSLKGLNQDATLLSTILSSIFIIDLENRLSSLVDNTLYEFKEKRKDRDLVCGFVHAVCSKINNQFWKSINYDVRKSTARILAQSLRSVVQLEDDLQPCQLTLLCASWMPEVLEYLSLDQTDEENICGLLLLESDVWPMWISPSSLASINTRDLPAHLYELRASKSQRFVSFIESLVMKMGIHRFLGGHKDNGLSSQAWLSAEILCTWEWPGGSVQTSFLPALVSYCKSEPARADLLNFIFEILLNGALVHGEDEEAERESSEHMWVELNNHIEDVQEPFLRALVSLTSTLFKENIWREEEAIAAFKMVTDKLFIGEETSKNCLRTIPFIMSIIISPLRTTTKSDVSGEDTGLPLEVFLRGWLERSLSFPPLVLWQSGEDMEDWYQLVISCYPVSEMAEEDKAPQMHVSNEERTLLLDLFRKQRQVPRASSVVTQLPAVQILLARLIAVAVSYCGNDFNEEDWDFVFSNLKRLIQSAVVVMEETSENVNEFISGVSSKEKEIDTLEGLGHIVSISDPSLANAKNALSAFSLLNALVKHKSVEGENNLNSLADEIWEPVKDRILEGVLRLFFCTGLAEAIAASYSPEAASLVASYRVDHLQFWELVAHLVVDSSPRARDRAVRAVEFWGLSKGAINSLYAIMFSSAPIPSLQRAAYTVLSTEPISRLAIVADGNASPSDESLIDQDSINVPSEERLGLRDEISCMVEELNYELLDTDLTAPERVQTFLAWSLLLSHVNSLPSLTQGRDRLVQYIERTANPLILDSLFQHIPLELYMAQSLKKKDAIGLSDLSGVASAAVLAITTGSSLSTVESLWPIDTGKMAALAGAIYGLMIRVLPAYVRGWFSEMRDRSASSSIEAFTRSWCSPSLIMNELSQIKKADFNDDSFSVSISKSANEVVATYTKDETGMDLVIRLPVSYPLRPVDVNCTKSIGISDAKQRKWLMSMLMFVRNQNGALAEAIRIWKRNSDKEFEGVEDCPICYSVIHTVNHSLPRRACVTCKYKFHKACLDKWFLTSHKKVCPLCQSPC
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKRDSNRNLVRKRADDSDSDDYNTFAGLEKDSGPEEMSSLSFGAIRNAQKNLDKENEDDSDSDSDSGPEENSGGYERSSYKGNNKGKGNNKEDGGPKKRLKHAPSEASSKKRVSVIRPIPGLTMTKSGADSASRDSKLYRDIRFDATYGKANEDRVREDYAFLDEYRREEIAELQAKLKKTEESYIRSQIQTQIQSLQSKLKTLEKRDFRKKVLNEHRQQQREQAKDGKNPYYLKRSDQRKLVLTEQFKTMKKKDIDRAIERRRKKITGKEKKDMFSGRD
The following text describes a protein:
Function:
Acts as a homeotic selector gene controlling antennal and mandibular segment identity.
Miscellaneous:
MISCELLANEOUS: The sequence shown is that of strain canton S.
Subcellular Localization:
Nucleus.
Sequence:
MTKMIPPVPTAAAAVMMPTPKQKIGFSIESIVGNDVSTAGGNSTPDLSGPQSPPPGERNVPGSPPQTPPATLTLIPGSPPHHLMAPPAHGLPYPHPHAQQQQQQHLQAPHPHPHLSPAQQHVLHQHLLMQHQHPGTPKSHQDIQELLQRLHHNAAMASGLSPLQTRLSPETEQPQMAVSLKRERSPAPPAMEQAENPAQRIQPPHTPPKSVSPQSSQPSSSPTLLISSPHATPPQQQQQQPPPNYPKPAMMHPGGAGPMMMPGMPPAGLVRPFPMGPGGPPMPQGQPGLPDIKALPPYINAPPELPPQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAGLPPHAAQFMPNPGMARDSYQLYPWLLSRHGRIFPHRFPGSFLVPPFRKPKRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKRMQQEDEKGGEGGSQRNMHNGSGDEDDDELIDMEMDECPSDEEHELDASH
The following text describes a protein:
Function:
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
Subcellular Localization:
Nucleus.
Sequence:
MSNDLLANLNAFKSKIKTAPVITTRRKVVAHQDSGSHSGGARQSKAMKRETPRDGGDQGAGQPSAAKKMKLGTASPQKAAVPSRSENGALDSTHLSTKMLIATEYIQERAEPVPIDQIESYLSLPKDNSVIPMLKGLAKFKFDPKKNTLQYVSIYDVHSAEELLKLTRTQVTFKGISCKELKDGWPQCFEVIDELEKKNRILVSRTKKDNSPRFVWYNFGGPLGEIDEDFVKMWENCKLPQRSELPRKLQDLGLKPASVDPATIKKQGSTRVEAKKRKQRKGKITNTHMAGILKDYSDRV
The following text describes a protein:
Function:
Viral serpin that inhibits both cysteine and serine proteinases involved in the regulation of host inflammatory and apoptosis processes. Major anti-apoptotic protein which inhibits both intrinsic and extrinsic pathways and strongly cleaves host CASP1 and CASP8 but is a rather poor inhibitor of host CASP3. Prevents the proteolytic activity of host interleukin-1-beta converting enzyme (ICE) and ICE-like enzymes. Can also block apoptosis through host tumor necrosis factor (TNF) receptor.
Subcellular Localization:
Host cytoplasm.
Sequence:
MDIFREIASSMKGENVFISPPSISSVLTILYYGANGSTAEQLSKYVEKEADKNKDDISFKSMNKVYGRYSAVFKDSFLRKIGDNFQTVDFTDCRTVDAINKCVDIFTEGKINPLLDEPLSPDTCLLAISAVYFKAKWLMPFEKEFTSDYPFYVSPTEMVDVSMMSMYGEAFNHASVKESFGNFSIIELPYVGDTSMVVILPDNIDGLESIEQNLTDTNFKKWCDSMDAMFIDVHIPKFKVTGSYNLVDALVKLGLTEVFGSTGDYSNMCNSDVSVDAMIHKTYIDVNEEYTEAAAATCALVADCASTVTNEFCADHPFIYVIRHVDGKILFVGRYCSPTTN
The following text describes a protein:
Function:
Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. Involved in the formation of free oligosaccharide in cytosol.
Miscellaneous:
MISCELLANEOUS: Present with 4850 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGEVYEKNNIDFDSIAKMLLIKYKDFILSKFKKAAPVENIRFQNLVHTNQFAQGVLGQSQHLCTVYDNPSWHSIVLETLDLDLIYKNVDKEFAKDGHAEGENIYTDYLVKELLRYFKQDFFKWCNKPDCNHCGQNTSENMTPLGSQGPNGEESKFNCGTVEIYKCNRCGNITRFPRYNDPIKLLETRKGRCGEWCNLFTLILKSFGLDVRYVWNREDHVWCEYFSNFLNRWVHVDSCEQSFDQPYIYSINWNKKMSYCIAFGKDGVVDVSKRYILQNELPRDQIKEEDLKFLCQFITKRLRYSLNDDEIYQLACRDEQEQIELIRGKTQETKSESVSAASKSSNRGRESGSADWKAQRGEDGK
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (By similarity). Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity). Involved in the maintenance of mitochondria morphology. Binds to glycerolipids such as cardiolipin (CL). Contributes to the export of phosphatidylethanolamine (PE) from mitochondria and to the import of galactoglycerolipids from plastids during phosphate (Pi) starvation. Promotes lipid desorption from membranes, likely as an initial step for lipid transfer, and regulates probably the tethering between the inner and outer membranes of mitochondria by binding to TOM40 proteins.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MLRKSVLELSSRLSIKRFPRNLGAQRFHLSSSRNASTSGKNGLPGAKPVGKPDASKVDPPKVTPPPPTKGNSSKVVIGGVAIAGAFLVAYQTGYLDQYLGKEQQKLSERIHSDALTEKLEEAHHLNVPSGVEDSTEKDGKVETQPQVTHSEASEGVQSDIELQPESDLSSDRFTYISSNQEETPQETVIDRAEINLPISASEDSGAKPDMPSEIISEAESVKLEAVPKPGDSPIIVNAQSSSVHRESETESASPKDPAALKTPEDGIEREVQLPGSLLKEYNLEGSDTESTGSSSIGEQITKETEAFPNSTEGLKDSYMTEDGKLVLDFLAAIHAAEKQQAHLDAQVFAEELRALKEKYENELRDLRARELMRIEEAAILDKELKRERTKAAAAIKAIQERMEDKLKAELEQKETEAQLALSKAEELAKAEMISTIAKEKAAQIEKMAEADLNIKALSMAFYARSEEARQSHSVHKLALGALALDDTLSKGLPVQKEIDTLQTYLEGTHKDSILGLVLSSLPEEARSNGTDTVLQLNQKFDTLKGTLRHFSLIPPGGGGILAHSLAHVASSLKFKEVDQANGGIESVIKKVDNYLAEGKLAEAAATLEEGVKGSKAEEIVSDWVRRARNRAITEQALTLLQSYATCVSLT