lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential protein. Required for male and female gametophytes development. Exhibits sn-1 acyltransferase activity with high specificity for acyl-coenzyme A, thus triggering storage lipid biosynthesis and playing an important role in the Kennedy pathway of glycerolipid biosynthesis. Catalyzes triacylglycerol (TAG) accumulation involved in membrane lipid and oil biosynthesis, especially in seeds. Also contributes to the biosynthesis of both polar lipids and TAG in developing leaves, as well as lipid droplet production in developing pollen grains. Seems to not contribute to surface lipid biosynthesis (e.g. waxes and cutin).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MSSTAGRLVTSKSELDLDHPNIEDYLPSGSSINEPRGKLSLRDLLDISPTLTEAAGAIVDDSFTRCFKSNPPEPWNWNIYLFPLYCFGVVVRYCILFPLRCFTLAFGWIIFLSLFIPVNALLKGQDRLRKKIERVLVEMICSFFVASWTGVVKYHGPRPSIRPKQVYVANHTSMIDFIVLEQMTAFAVIMQKHPGWVGLLQSTILESVGCIWFNRSEAKDREIVAKKLRDHVQGADSNPLLIFPEGTCVNNNYTVMFKKGAFELDCTVCPIAIKYNKIFVDAFWNSRKQSFTMHLLQLMTSWAVVCEVWYLEPQTIRPGETGIEFAERVRDMISLRAGLKKVPWDGYLKYSRPSPKHSERKQQSFAESILARLEEK
The following text describes a protein:
Function:
Required for mitoribosome formation and stability, and mitochondrial translation.
Subcellular Localization:
Mitochondrion.
Sequence:
MKQGPAWARTASRSMAQAAAATERPQPTAQPHPATRVTIDELFDARVHLGHKRGMWNPKMEPYIYTTLADSHIIDLNVTKAHLEHALELTRRISADGGVVLFVGGRPQFEGLIRHEARRCGEYFVTRKWIGGTLTNNTEARTSHRLVHGVQTLGGLRMPDLILFFCVPVSKVGVKEALDCDIPSVGIIDTDGDPDGVTYVVPGNDDTTQAIEFYVRKFADAVLAGKEAISDEQ
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
KERKKTLEPIKLLQQHFLSSLPRSHPVTFKFENGLFGVLNALPSFPRLAGRVRSPKRDLLVGRPLGAPRGRGETGSPAAGSRRPRPRRTLPSRRPGNAAVRAPEPHPQPRGAPRRGRGGPRASPPPPGPAAGGGGGGGGGEETPGPRRRTWRPRLSPSAVSLRAPASAAASLAGTPAGAAPRKDRTHGHAHGHTHGHAHARSAAAADQAEAPRRGAAAAARTGAPSAASPLLVSQRRGGRRAGRRAGGRAGRPGAPRGRPSPPSPRPPSAAPRGGGRSVPAQSRLLPAPAPPPPRRRRPPPAAAAAPAAPRRPRCSAKGSKMAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPVEIDMIVGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRVLVFVMGKEGVHGGGLNKKAYSMAKYLRDSGF
The following text describes a protein:
Function:
Involved in the uptake of iron; Part of the ABC transporter complex FeuABC/YusV involved in import of the catecholate siderophores bacillibactin and enterobactin.
Subcellular Localization:
Cell membrane; Lipid-anchor. Cytoplasm. Membrane raft; Lipid-anchor. Note=Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion.
Sequence:
MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYLDKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGEKMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLTGKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYGDLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWKSLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN
The following text describes a protein:
Function:
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.
Subcellular Localization:
Cytoplasm.
Sequence:
MIHRHLQHSPFPVLLVEPQGRIVQASPASLEFLGIGSRHSAPSALADIMHAEQCEAVLRAGAALTDTGFWEGECSLIGRDGQPVRAFLRVARAGDDRLVMYLRDSAGRSRSEELLRIRLQLSERARCESLDELLRSALDAAERLTDSSIGYLHVVAPDREQASLQAWSSNTLATMCRVRGEKEHHPTRRAGIWGDCCRERTAMIHNDYAGLPHKKELPEGHPPIVRVMGVPIIHGDKVLAIIGVGNKATEYIREDADALHELASMIMDLVERKQAEAQLLASEKRFRTVFEQAAVGVALVDPLTGRFVRVNAKYGDIVGYSPETMLTMGFQELTHPDDLAVDLECISRLLKGEIRTFTREKRYLHRDGCNVWVRLTVSPLWADGEEPSFNIAIVEDITARKAAEAALREAKEQLELRVRERTADLEQANRALQEEVAARSQAEESLRASESRFRRLVQMAPLPLCFADASGTLRYVNDRFTRLFGYAPEDIPTQEEWWSRVCTDGRCRGETADAWQASVQRGPNGASDIEPAEFRVACKNGDIRLVEVSGITIEGTVLATFIDITERRLAEDELHRHRELLEELVHQRTAELKLRNMELASEIAERRRAEAALRCYTRRLTEMEEDLRKKLAAELHDEIGRDLTALNLNFSVIGNRLVQGPDGCLKARIEDTERLIEDISRTVRGLTAKLRPPVLDDYGLPAALRWHADLFSRRTGIEVTVRGADSVPRMPAEKEIALFRIVQEALTNCSKHANAGNVKVSLDHGDGRVRLSVVDDGIGFAPESASPTPAGSGWGLTIMRERAELIGGTFRLNTAPGKGTVLTVEIDEGS
The following text describes a protein:
Function:
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
Sequence:
MKRYVVGISGASGIVLAVTLVSELARLGHHIDVIISPSAQKTLYYELDTKSFLSTIPQNFHNQIVLHHISSIESSVSSGSNTIDATIIVPCSVATVAAISCGLADNLLRRVADVALKEKRPLILVPREAPLSAIHLENLLKLAQNGAVILPPMPIWYFKPQTAEDIANDIVGKILAILQLDSPLIKRWENPR
The following text describes a protein:
Function:
Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract. Required for the establishment of radial spokes in sperm flagella.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MSEIEKENLIKNVVREICQECHLKGKAVSESLASFIIKAVLLHPKNGFNINNPTTKENLDKLTQLCVEKLTKNDEPSMDTIKMQIYFDENFVDRETFEKEDIAALDGQLSKKLEDIISRDVEGCKEQECLYKKIIRFIMYKSELGCMSNSDSIKEFSAALSSVMPISEIQCFLKFSKSKRAKQLMELTWIVAGVVLFNKESGKGGENIEDVGKTLNNLIPNISLLVDEKLSEVHNHATTTTTEMLEYYRATVRDLPDLMNSNAKQCLINCCQHVLYLKLMKKLVANAAKMVDKEVTSLAHVIKSIKNSVSKTVVTALRIFPQFTKLSTIWSMLMMELKYMHLIIGIFNDLHQFTQVLPGYFSLMNFCHFSLRNIPENCFDMQLKRIHDINKTDDVMILFPETTSNYWRLPLQFRGYCCWTLVNRDILLVPGNLNLGIIYYKKCCYAFTSNRAAVDFVSDPVSYLKGVAQLACSNPELIHLLELYHLFTSLLPYEQANEEQNELEQPLLKSECASQTDTHFCESNIVRTYEWNEWQMRRMAIRLANLRNKRSKSTQTKMSNMRRDIFTQVYRKKTTETQTKMDAGSNVPRPQIFLAGLRGTNPTVYNKVDLTLRDDEDYND
The following text describes a protein:
Function:
May be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development. It has a role in the development of the HYP7 hypodermal syncytium.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MCLKMRYERIKYILLFSLMHLVYSNSTFESFTENPHISSQISNVLYMDQMFIIYILICILLILISVIVYLSKRYSQQMMQSSDNITNRRSNPEVRNKSNIYDLPPLLDVTSVNEETPIVKRPINERIENLEFDPRFEIDQAKLEISEDKLGSGFFGEVCYGLLSMRTSNTETDTLQKLSVAVKQSNDPTQENQEKMIEDETKLMCAIGRNPNILAIIGAVTANSGSARNLLIVEFVECGDLLKFLEEKKSIFKDELVYEKNGYLLPKSIRRKTYMFNENEDDVIEESLDSLCTSDLLSFSYQIAEGMEYLASIPCVHRDLALRNVLLNKNKTIRIADFGLARKYQVDGYYRITKGVGTPMPARWMAPEVMREGKCTEKSDVWSYGVSLYEMFSLGELPYSNVSNSDVFEHVVQGNQLPMPQYCHPKMYDRMKQFWNFDATFRPSFSKCVEFFEEHLSVSATNLLEQIQKTLKSEAERQSKLEDWIRRD
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MERILRGIMRYRNTTREQMVKEFQKVRDNPEPKAVFFTCMDSRMIPTRYTDTHVGDMFVVRNAGNLIPHAQHFQDEYFSCEPAALELGCVVNDIRHIIVCGHSDCKAMNLLYQLRDPDFASKLNRRLSPLRSWLCTHANTSLERFQEWRDAGMKDPLIFSSETPLRRFVAYIDEEQKFALEDKLSQINTLQQMSNIASYGFLKARLESHDLHIHALWFDIYTGDIYYFSRGAKRFLPVDEDTVDRLSEEVRRFYS
The following text describes a protein:
Function:
Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSFNGECGIEPNGTENAIKAAEGAKRTTVQHQQLPPRPKLVPIYPSAQAQTPPSCSTGIEGKLRSTLPFEFSGLCAETCSQGRENGVWASIITAPAYAPMQSWLTVMQSLIRHPERNSTNILRADILSEILASDKRPDALSEDAHEKGWKRQWTVRRSLLPRRPNLDWSMLQDCSLYYRYNSTARKTKDEPDFHQQEKAEEGNGAEVEEAVVVYTPLVGDVSHPKMDLPESCKPTTSTTPPAAAQAQIGYPPPHESYIPFYHPKVRALAFHFHAIAPQDSAGETRFGQLGISLIPFSSPHSTLAPPSYPPTHRLSRVSLSLLTTLHVHTWGDLHSYRKRVHHDQIVPRSLYQDVYLSLKAKYASELIAGWKEATDPSKHVFEEMGIAAFLIGLWELHYRKQADDEREWKNSVKFVDVGCGNGLLTHILMREGFIGVGLDMRERKSWPSFRLHGSVLQEWTFNPSNLVSSPSPDKLEPEIWKGAWLIGNHADQLTPWLPLLATHYRSAGFINLPCCYYALDGTRDFPLLLKAEAGENVSRNEQYLAYVSHLHRWSGWKVELDPLRIPSTKNWCFIGRTRETASVEAVQGDQDSLLTQRVKKAVEQASCGAWGKQIPRPSDKT
The following text describes a protein:
Function:
Involved in a signal transduction pathway that is activated in under conditions of heat shock, oxidative stress or limited nutrition. Unlike win1, it is not activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation.
Sequence:
MGLEHTFYPAEDRFEPLLEHSEPVNFVPKENAKSYVRQGFASPHQSLMDNLVDSTESTKRSENFVSHIPLTPSHSGQSEKLMSTRTSHSPYISPTMSYTNHSPANLTRNSSFNHQHYSTTLRSPPSMRGRGIDVNSSHYPHISRPRTSSDSQKMYTRAPVDYYYIQENPYFNNIDQDSISDKSLPSTNQSLHHSEEDTESDNDFSESIHPEFDIDVFYKVSNILYDESDLQDPEKRERLEWHSMLSSVLKGDVMQTEKRRLRLTEPDGHSGTYISEVWLGLQAWLHGRLNADQAEVIRKSREGVEPVLREVIDFQIQDEETTKPPLEQVTEILEKVEQCKQFYISSREMEENVPLSASKEFNYKLNALISWSNVMESIQVETLVLQKWVGNDEFDLTMRTPQFNYDGVENTSSFVERIFRQSGLQRTFEQRTLTTLNRIIHQAKQTISENAQAFEEMKLPTYEDKLLPLVRFPIKLLEEALRLRLAYAKKIKGPNFLIVDSMLDDFKIALSVAVRIKREYIKIASPSPGWSLPTNVDEDYDNVLLDSLKFYFKLLTLKLSSGNKNLYFKEIDFLENEWAFLNEHIYWINGGDIHMAGQFSYLSNSLLLNVHRYVESHLNGPTERTAASLTNWYSTLLKNTQIRFRKILRFSETLNSRFENASDFVISEGHLPDLVNRLSTTGHFLAYTANLERDGVFVIADHTLSENPEALKALLFSKDISNLETIQQNCSYVLILCPVHPIVWKGRIEKVDVPDFSVDLKTNRVRIIASNKREHLQAAKSVFQSISGDLVTLAVECRSSITRVYKEFIRLSKLCMRISSTVVDCVSAVREACSGVNCHDLIYHVFSFAAEFGQRILRFLSFDSYWQTKLKRKITSLAVEWISFICDECDLMDRKTFRWGVGALEFLMLMIRGNNILLIDDAMFLKIREKVGKSMAFLLTHFDVLGAKSKVAAKLQRESTEVSSSPRLTSFGDVEEEALSIQLLQKETMLRIDELEIERNNTLLERLAIGHVLDDSVFRNRDFIKLASSFSNITIRWQQGHFVRSGMFGDVYTGVNMETGDLLAVKEIKLQDSRTFRSTVDQIHNEMTVLERLNHPNVVTYYGVEVHREKVYIFMEFCQGGSLADLLAHGRIEDENVLKVYVVQLLEGLAYIHSQHILHRDIKPANILLDHRGMIKYSDFGSALYVSPPTDPEVRYEDIQPELQHLAGTPMYMAPEIILGTKKGDFGAMDIWSLGCVILEMMTGSTPWSEMDNEWAIMYHVAAMHTPSIPQNEKISSLARDFIEQCFERDPEQRPRAVDLLTHPWITDFRKKTIITMPPATITKKTSLSHTITEEKTAQLLAGRHDDSKAETDSLAASYKEESALPVASNVGLRQPNELRIDSINLPPAIVTPDTINYSVD
The following text describes a protein:
Function:
Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytosol. Note=Exhibits a diffuse cytosolic localization.
Domain:
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). Essential for its ability to link NOS2 and the ECS E3 ubiquitin ligase complex components ELOC and CUL5.
Sequence:
MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPLPPAMKRYLLYQ
The following text describes a protein:
Function:
Transferase that catalyzes the transfer of sulfur from thiosulfate to thiophilic acceptors such as cyanide or dithiols. May function in a CysM-independent thiosulfate assimilation pathway by catalyzing the conversion of thiosulfate to sulfite, which can then be used for L-cysteine biosynthesis. The relatively low affinity of GlpE for both thiosulfate and cyanide suggests that these compounds may not be physiological substrates. Thioredoxin 1 or related dithiol proteins could be the physiological sulfur acceptor.
Miscellaneous:
MISCELLANEOUS: Overexpression of GlpE can complement the growth-defective phenotype of the thiosulfate-grown cysM deletion mutant.
Subcellular Localization:
Cytoplasm.
Sequence:
MDQFECINVADAHQKLQEKEAVLVDIRDPQSFAMGHAVQAFHLTNDTLGAFMRDNDFDTPVMVMCYHGNSSKGAAQYLLQQGYDVVYSIDGGFEAWQRQFPAEVAYGA
The following text describes a protein:
Function:
Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1. Also able to mediate the transport of dehydroascorbate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTPEDQEETQPLLRPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLRRAAPPAPHLDEDAASWFGAIVTLGAAAGGVLGGWLLDRAGRKLSLVLCALPFVAGFAVITAAQNLWMLLGGRLLTGLACGIASLVAPVYISEIAYPEVRGLLGSCVQLMVVTGILLAYLAGWVLEWRWLAVLGCVAPSFMLLLMCFMPETPRFLLSQHKHQEAMAAMQFLWGYAQGWEEPPLGAQHQDFHVAQLRRPGVYKPFIIGISLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGVIQVLFTATAALIMDRAGRRLLLTLSGVVMVFSTSAFGAYFKLTEGGPSNSSHVDLPALISMEAADTNVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGVCVLTNWFMAFLVTKEFSSLMEVLRPYGAFWLASAFCIFGVLFTLACVPETKGKTLEQITAHFEGR
The following text describes a protein:
Function:
Essential protein which may play a role in mitochondrial morphogenesis and function. Has transfer RNA (tRNA)-binding activity and can bind tRNA(Ser) but does not have serine--tRNA ligase activity and does not bind ATP.
Subcellular Localization:
Mitochondrion.
Sequence:
MLSLRSVLKHCLSAKKTCSRNISALYITGDKANENYVTLQPYMDFNKTFGERQFLEQSISSRGLDIRLETVLSKYEKYKTHHAQLSKVAEERERVTKRLKELTKSGSSAVQLEELKEHGKSLRNELKALKQTLYPIEDDFIHDYLHLPNLLHVQCPVGGEEKLLYRHGIPKSENKTTSHLARQELVHFVDNNRYYLMEQAALFDVNAMQSLARYFVNHGHFIQTANPDFVRCVLLEANATPLSDYHLVQEEHLQNKINTAYLTGGASFESYLGAMTKLCVYPSVLPLRYVCCGRSYNRAEADLYGPIPSLYTATQTNAVQIFVATQTDNEADSQLEHILNLATDFYKALDIPFRISYATAADLTPAESIRAVIEVYAPSLQRYVCVGRISNYGDFVSKRILFSTRREKHYDFLHMVGGPVLYTSRLIAALVEHGVRLEDCKLLGSISQKPVHQQDLQQFKDLFT
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcriptional repressor RIM101 in response to alkaline ambient pH, which is necessary for sporulation and invasive growth.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVSMIHIVVFLLAITTMFEILPLITVPVTKYLSLSSFRNHYYGLFGWCVRGQNQELMCTKMKIGYDSTDVDSSGHVLTLPSNSKVVVSNLLVVHPISLAFTGTLLILAVIIMVTPLGDSPEMLLFTALFSLPTFMLCLLCFLVDILLFISKLDWPGWLMLAATISVALCCSMLWVMRRVVSVKKYESQQSIAHACSMEQYSISDIYQSKQNGNSSEYEVAPTHTDSLIAPEVTYRGFIE
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MDVADSTSETPPVFDHDNLALAAQTNLLQFYLTHLASTLVPPMKLDMRDSMTPSFSQTESPNSETDDSTSAANKVLFSILGTPTTDSTSNAVSKSSSKLCSVCGDKSTGLHYGAATCEGCKGFFKRSVQNKKVYHCSQDNCCEIDKQNRNRCQSCRFRKCISKGMLTEAVREDRMPGGRNGNSIYSNYKQRRSIIRKTKDYVEEQERRPFQSLPSGKKLIKELVEMDCLDRLINLKGLRINPSANCDIAPACKRLTRIGDEIVEQLVEWTKTLPFFDELPVEAHTHLLTQRWAELVLLSAGYYACSVFTPDSPDTTEMIDETDEISFTNPQVNLRLLQNRLSLVLGKEIPLEHVAKEAGPLVTRFTTLLHSFSNLKVSPEAYVCIKAITLLHLSADSTLDRSIIDKVNTLQDHFVKTLQIHLHQPGEDAQTTSLAQILDWLPDLRNASSVLLHSKMFYVPFLLCKNPRRLVFDE
The following text describes a protein:
Function:
The B regulatory subunit may modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Sequence:
MDPNKVPEKQKAAEAKELSIQGAKRKRVVVPGPSQELETDLERHRAEKIRKNEEFLASLGIESNFLASKKAQTGAKVKQARKVAPPVQMPVRRSTRARGLVADSDSGLVMSSPTAPRVEPEEELEPLHYDDSSVRKYTCRTQWEGATEKCSDLGVQAFDSLQPTGVSYCDPLMTRVYALVAREGCGGRLLAAGGHAGRLAVFGLREAAELAASDCARVDTRGDGDMETAHGAAEEPLLAWKGGNGWISAVQFLTRQQQEGATLLLTSSNDRSVVLWDIDKTSNSTGTPRIVAETSSIHNNGIFGMHELGGKIATASKDKTVGITVVTEAGLEPVTVLSGHHSAAVRAIHFRDSHHLADGSADCSVAVSDLRLADPGSLCIENAHNSAINVVQWHPTNEHLLMSASHDRGICLHDIRATQQPLFTFVGHLGPTLARSKSIYRPSFLGAGRYLASPGEGSQAISLYDVASGKTVSRGCLGFDATMTMAGKMGRDLWVAAQGGLVRKYKASLSAAAI
The following text describes a protein:
Function:
Required for cytokinesis in both mitosis and meiosis. Has a role in actin cytoskeleton organization and is essential for many, if not all, actin-mediated events involving membrane invagination. May serve as a mediator between signaling molecules and actin organizers at specific phases of the cell cycle. Possible component of the contractile ring or may control its function.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cleavage furrow. Apical cell membrane. Note=Localizes to the site where the metaphase furrow is anticipated to form, to the growing tip of cellularization furrows, and to contractile rings. Recruited to the apical cell membrane of epithelial cells in a Rho1 dependent manner, enhanced by phosphatidylinositol 4,5-bisphosphate (PtdIns[4,5]P(2)) enrichment established by sktl/skittles and Pten.
Domain:
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity). DAD-mediated autoinhibition negatively regulates dia localization to the apical cell cortex; The N terminal basic region is enriched in basic amino acids that may mediate interaction with negatively charged phosphatidylinositol 4,5-bisphosphate (PtdIns[4,5]P(2)). It is required, but not sufficient on its own, for efficient apical localization in polarized epithelial cells; The GTPase binding domain (GBD) probably mediates interaction with Rho1 required for disruption of autoinhibition and targeted recruitment to the apical membrane of polarised epithelial cells.
Sequence:
MSRHEKTKSTGGGLLDSLFGRPSKSKGGTISSGTLAHGGRPVSADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFEKPIDYVEYLQNGEHSTHKVYQCVESLRVALTSNPISWIKEFGVAGIGTIEKLLARSKNNASYEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQLESAKQEAEAKAAHLEEKVKLMEANGVAAPSPNKLPKVNIPMPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRVTNGQLMTREMILNEVLGSA
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.
Subcellular Localization:
Nucleus. Nucleus, nucleolus.
Sequence:
MEDDQELERKISGLKTSMAEGERKTALEMVQAAGTDRQCVTFVLHEEDHTLGNCLRYIIMKNPEVEFCGYTTTHPSESKINLRIQTRGALPAVEPFQKGLNELLNVCQHVLVKFEASIKDYKAKKASKKEPTF
The following text describes a protein:
Function:
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MKNLIAELLFKLAQKEEESKELCAQVEALEIIVTAMLRNMAQNDQQRLIDQVEGALYEVKPDASIPDDDTELLRDYVKKLLKHPRQ
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.
Sequence:
MLSYQDLFLFSIIIIVLFGSSKLPEIGKGLGEAIRGFKKAVSDSESNSNKDMDETLKIEHKKQS
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MPPTPSRSAQRGGARQRQGSSLHPQSGTTSGPLATAGPGRSSVQPARGAKATQTHDPGAVPFIHPALALSSGVLPSSSSSTAGLPAAAVAQVRGRRPFNHRNLFARDLRNLMYAYGDSPNPDPDSVMLMEEMTVDFITDLCCRARPSPYSLGLGTSSISNSSSAFGATLEQHLSSQDPNGLLDGAEAMPQTLPPRAPHRLRVKLEDFRHALRKDVEAKKLGRMEQLLYADKVVTEARRVGGVEEAAERAGAMQTDNLPPPTSNMDGSSQNASLEGLDVDEDDTQASKSGKAGKGKSKGGVGGSKGGGKGKAKPKGTAAV
The following text describes a protein:
Function:
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Sequence:
MTITITNIKRVGSEQTESLTIENGLIKGWNLPAEGEIFDGQGGTLAPALIELHAHLREPGQTEKEDLASGLAAASAGGYGTVVCMPNTRPVIDDPALVRSLIEKARGLGFARLRPAAAVTKGEKGEQLTEMSYLKEAGAVMFTDDGLTNENARVLRLGMEYAKSLGMVISVHAEDDALRAGGVMNEGPVSESLGLPGNPAAAAAARVARDMEIVALTGARLHVQHLSTARELDIVRDAKRRGLPVTCEVCPHHLDLTDESLRTFDAMYKVAPPLRTRADADYLLEGLLDGSVDCIATDHAPHTRAEKERDLLDAPSGIAYIEIAFPIMWTRFGERLGLEKLIDLMTAGPARVMGWPEPSLEAGAPADMVVLDLETEREVNPAEFKSKAKFTPWQGQKLRGFPLLTVVDGKVAYRRE
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as regulation of organ-specific terminal differentiation during development.
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Domain:
Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity); In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Sequence:
MARDLKDCRVPCKLLLEDLQALCRRKKLVCKQLSVTKNNFNDYEVEYLCNYKKHKGREFFLVKWKGYEESENTWEPLKNLKCPILLHQFRKDMKAALLQANEPLDSASLSGPIISFLRQKATQRIRLKKWEDLMNQTCWHKGRIFVSNEVDMDGPPKNFTYINENKLGKGVDMNAVIVGCECEDCVSQPVDGCCPGLLKFRRAYNESRRVKVMPGVPIYECNSKCRCGPDCANRVVQRGIQYDLCIFKTDNGRGWGVRTLQRINKNSFVMEYLGEIITTDEAEQRGVLYDKQGVTYLFDLDYVDDVYTIDAAHYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIALFAKRGIKAGEELTFDYKMTVDPVDAESTKMDLDFSRAGIEGSPIKRVHMECKCGVRNCRKYLF
The following text describes a protein:
Function:
SNARE required for protein transport between the ER and the Golgi complex.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MNALYNHAVKQKKLLEQELNRFELGVAAPVGLQGSISTALVGLERTIEQYQAQVAQTGSGAEAGKHAQRVGELTECAASARRRFEGLRAASMQPVAFQSGAAAPEGAVSQRAAGARTTINSAGGLPLYEGLRREQNMLARGNARLDSILQMGQESLEDMVEQHRILQRVAERMQGSLRTLGVSDATIERIGRRVKKDKAIFWSSLTLLVVGVYYVLRIFG