lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Has a role in proliferation and development of cortical neural precursors. May also regulate bone homeostasis (By similarity).
Subcellular Localization:
Nucleus. Note=Localizes to chromatin during prometaphase.
Sequence:
MPKGGCPKAPQQEELPLSSDMVEKQTGKKDKDKVSLTKTPKLERGDGGKEVRERASKRKLPFTAGANGEQKDSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVALLMQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSGDPKLKEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPASGADSKDWLAGPHMKEVLPASPRPDQSRPTGVPTPTSVLSCPSYEEVMHTPRTPSCSADDYADLVFDCADSQHSTPVPTAPTSACSPSFFDRFSVASSGLSENASQAPARPLSTNLYRSVSVDIRRTPEEEFSVGDKLFRQQSVPAASSYDSPMPPSMEDRAPLPPVPAEKFACLSPGYYSPDYGLPSPKVDALHCPPAAVVTVTPSPEGVFSSLQAKPSPSPRAELLVPSLEGALPPDLDTSEDQQATAAIIPPEPSYLEPLDEGPFSAVITEEPVEWAHPSEQALASSLIGGTSENPVSWPVGSDLLLKSPQRFPESPKRFCPADPLHSAAPGPFSASEAPYPAPPASPAPYALPVAEPGLEDVKDGVDAVPAAISTSEAAPYAPPSGLESFFSNCKSLPEAPLDVAPEPACVAAVAQVEALGPLENSFLDGSRGLSHLGQVEPVPWADAFAGPEDDLDLGPFSLPELPLQTKDAADGEAEPVEESLAPPEEMPPGAPGVINGGDVSTVVAEEPPALPPDQASTRLPAELEPEPSGEPKLDVALEAAVEAETVPEERARGDPDSSVEPAPVPPEQRPLGSGDQGAEAEGPPAASLCAPDGPAPNTVAQAQAADGAGPEDDTEASRAAAPAEGPPGGIQPEAAEPKPTAEAPKAPRVEEIPQRMTRNRAQMLANQSKQGPPPSEKECAPTPAPVTRAKARGSEDDDAQAQHPRKRRFQRSTQQLQQQLNTSTQQTREVIQQTLAAIVDAIKLDAIEPYHSDRANPYFEYLQIRKKIEEKRKILCCITPQAPQCYAEYVTYTGSYLLDGKPLSKLHIPVIAPPPSLAEPLKELFRQQEAVRGKLRLQHSIEREKLIVSCEQEILRVHCRAARTIANQAVPFSACTMLLDSEVYNMPLESQGDENKSVRDRFNARQFISWLQDVDDKYDRMKTCLLMRQQHEAAALNAVQRMEWQLKVQELDPAGHKSLCVNEVPSFYVPMVDVNDDFVLLPA
The following text describes a protein:
Function:
Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm. It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm.
Sequence:
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV
The following text describes a protein:
Function:
Encodes a member of the mid-SUN subfamily of SUN-domain proteins that is localized to both the nuclear envelope and the ER. It is involved in early seed development and nuclear morphology. [TAIR].
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MQRSRRALLQRRRALEKTTCGRNRVYKVSLSAVAVLWALVFLLNLWIGHGDVNEDGAGDFPVPVGSWDEDKPQYGSGTCAALPETETSSQEISSEDSAKILCTEAGKNQVNGETPDVVQNSNPVPANQQQASEGKPESTPSSEKDASKSDRFARAVPPGLDEFKNKAFNAKNQGKSGQAGGIIHRLEPGGSEYNYASASKGAKVLAYNKEAKGASNILSRDKDKYLRNPCSAEEKFVVIELSEETLVDTVEVANFEHHSSNLKGFELLGSPIYPTDTWIKVGNFTAGNIRHAQRFLLPEPKWVRYLKLNLLSHYGSEFYCTLSILEVYGVDAVEKMLEDLIFDQDKLFVPERTNSDEKSVPTQHVSNQGEFVQDIDDEIEKDLAVGKSDVKRGVMTTDVPDQVEEVRHQQVNRMPGDSLKILMKKVRSLDINLSVLERYLEELNSRYGKIFKDFDSEMGEKDALLQNIRSDIRGLSESKDSLGKEVADLVSWKSLVSTQLEDIIRGNAILRKEVEKVQRNQVHMENKGIVIFLICSFFGLLALVRLLVDTVLSNYRSENSRKFCSESYSWYFLLLSCTITIIILSL
The following text describes a protein:
Function:
Transcription repressor.
Subcellular Localization:
Nucleus.
Sequence:
MDTNELYALEESLKQYEQQLQAVHIALESSDDAQASDLLELKQNLEEVICLTKTTHAQNPATEATEGRRSLDDSSQSIDDEFARFQAEIAGLGGTSGPADVAGSAAEEDHSKELAELTDHLEGSKVRAPYSKDWGQMEYHNAIVLSVEAADIAHVDDIRVNVMFTHPTTPSMKPCSFFLEGHCKFSAERCRFSHGHAVPLSDLQEYAEPSFSSMQLGSTCLIRNDSDGLWQLATVDSDQASTLSKSSAGKIMVRLSRSGKAISVAAEDVLPLGDYGGAEDSDSDSDLDLSTEDGPSEMCLPPSEASEEDASVPVIAWMPNESASFPLGLWEKHTKGIGSKLMEKMGYVWGEGLGIRGNGRTEPVEAVILPAGKSLDKCMELREKGLTQNSAKVQRKMLLKLQRQEEKLQRQYHKASKPESVFDFFNGHIFSKKHNKGSGAQSLLAEEKSASQDIKSTSSKGLSVEVCLGPIRQPRLSWLLIGTKSLFFFFFCRDKLMHAKVEKKIEEQRQLIRQLQSRERSIQAEQQHRMGNDKLRIF
The following text describes a protein:
Function:
Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. This is a collagen critical for organismal morphogenesis. Mutations in sqt-1 can lengthen, shorten, or helically twist the entire animal.
Sequence:
MSVKLACYVTASVTVATLMVCFMTMSTIYSEVDGFREKLDTEMNVFRQSTNGLWKDIVVIGRSSKRVRRQYEETNATPTPHADGSPSAPPGQPPAVPPVFNQPKTPNGANGNGPTCNCNADNKCPAGPSGPKGVPGVPGLDGVPGLDGVPGVGADDIAPQRESVGCFTCPQGPVGPPGALGRPGPRGLPGPRGQNGNPGRDGQPGHPGEQGSSGQIGKIGEPGPPGEKGRDAEHPIGRPGPKGPRGDQGPTGPAGQNGLHGPPGEPGTVGPEGPSGKQGRQGPDGTQGETGPDGRPGKDAEYCQCPDKSPPSEAVNANRGYRNI
The following text describes a protein:
Function:
Seems to play a role in sperm motility.
Subcellular Localization:
Cell projection, cilium, flagellum. Note=In mature sperm, localizes in the midpiece of flagella.
Sequence:
MMKKNRNKKAMNKQEALFIPHYYRLGHLKNILDGGEYAPYVSPPILESNFIQVNRRGESIYLHNRANWVTVGICSSNPIFKTPNMMLLAHLTPEARKEPEPLFKTLLKSSSSGTLVLTRFIPLQFVTLSVHSAKNMRLKVKLINGRSYYLQLCAPVYKQDIIFSQWVDLIPLLNQEKIKNTKVSEVSSLSELTNSTDIAGSMDITDITAFRELRPRHPKTHRYPCNIMESADFSEYTDVTDVTDVTDVTDMLDNGITDVQDIKIVTEVTEVTEVTEVTEVSEVSDVKMATNISGVKIVFENDDIIKTKQEEKEYTLKHRSLQDTKTKSDYQDSPNPVTMSNIALALQDEGCFQTTQTPVKSKEDIYKEICDETSEENMIRLQNIHLKATESRSTRTDSDISDGELKLGRYLHKQCSSREQSFIHSLGSLPRGFVFLHLLL
The following text describes a protein:
Function:
Involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme (Cys-321). Also specifically repairs the Sp diastereomer of DNA methylphosphotriester lesions by the same mechanism, although the methyl transfer occurs onto a different cysteine residue (Cys-38). Cannot demethylate the other diastereomer, Rp-methylphosphotriester. This is a suicide reaction: the enzyme is irreversibly inactivated; The methylation of Ada by methylphosphotriesters in DNA leads to its activation as a transcriptional regulator that activates the transcription of its own gene, ada, and other alkylation resistance genes, alkA, alkB and aidB.
Miscellaneous:
MISCELLANEOUS: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.
Domain:
Consists of two domains. The 20 kDa N-terminal domain repairs the Sp diastereomer of methylphosphotriesters and, in its methylated form, binds DNA in a sequence-specific manner. The 19 kDa C-terminal domain repairs the mutagenic lesions O6-methylguanine. Each domain retains its activity when separated form the other.
Sequence:
MKKATCLTDDQRWQSVLARDPNADGEFVFAVRTTGIFCRPSCRARHALRENVSFYANASEALAAGFRPCKRCQPEKANAQQHRLDKITHACRLLEQETPVTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLRESLAKGESVTTSILNAGFPDSSSYYRKADETLGMTAKQFRHGGENLAVRYALADCELGRCLVAESERGICAILLGDDDATLISELQQMFPAADNAPADLMFQQHVREVIASLNQRDTPLTLPLDIRGTAFQQQVWQALRTIPCGETVSYQQLANAIGKPKAVRAVASACAANKLAIIIPCHRVVRGDGTLSGYRWGVSRKAQLLRREAENEER
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Sequence:
MPKKPKWYVVFEGRKRGIYTSWDVCSSLIKGFSQAKYKSYLTQKEAEDVFQNYITIHPNPITNEEIIEKRIIKDNNKKDTILVKEDIIIPSFNEVKLPSQMKQSNNSSFGIRFSQNKNGLIRTDINEVVIPGIQSVELYKKGIEYLFYNHLIEVGYKLIIPLCYFQQIQVSSLLIPLQTIYDMIIQIE
The following text describes a protein:
Function:
Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
Subcellular Localization:
Cytoplasm. Early endosome. Nucleus. Recycling endosome.
Sequence:
MGNCLKSPTSDDISLLHESQSDRASFGEGTEPDQEPPPPYQEQVPVPVYHPTPSQARLATQLTEEEQIRIAQRIGLIQHLPKGGYDPGRDGSEKKIRECVICMMDFVYGDPIRFLPCMHIYHLDCIDDWLMRSFTCPSCMEPVDAALLSSYETN
The following text describes a protein:
Function:
Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Midbody.
Sequence:
MSSDLQNQYENFKKTMKKAEYKEQFTFDYVQDNNPTVFLRILHYILIEYNSGFYKSLLDKGYELYSKNDLRFTEQVFKMLQFEFNYKSSINIAQFLSEQYLEHKLILINDIFNEVLQRTKKDKKVNIFKGQENSSHLQNTQKSQESNNKQKTQVFVQRENFQTEDDEEDIEQPKRPEPYKITQQNELVQKMPSYNQEQYEELEQQCNYTLQLQQQPSPPQSNQKNEYQNEIQVLQAFKQQINQVSQVNPIQTNNYIQQNGVTHQDLQKLMQVILLSNDNIKTIMQKFSELQTTVNIALANFDQRLTRLELKIRDQ
The following text describes a protein:
Function:
Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair (By similarity). Sequence-specific DNA-binding protein that has a high affinity for a 31 bp sequence in the Yp1 gene. Site-specific DNA binding to 31 bp P element inverted repeats.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MSTWNPENDVDLLSGSEDEEDVSMKRDYHGREAILFVVDANLQTAGVERLLEALNIIRTAFISGLLVNDKDLIGLIFANTKHSPPPLEASALDNIVMPDNCAVFLPLRQLTKPIVEHYLEFMGGVETQFADVYGLAEPDGRGRFDLMIRLCIEMLEKCGKKLNNAKIAYVTDVREPHPSNSNHFQAALQKASDLEGKEFEFHVIPMVDDFDYEPFYKEFITLSRAIELDAFQVPDAQMLREILSDRKLKQDFLRRCLGHFSFYLGPNLSMSVQYYNYFQRRAYPRKVQILRRDNSVVRTKRVITVQKQKDDGSQDIEHEYQIKVTGGWYTCNVGERDLRISMDQLNRVRNLHKPQMMLLGFKHRSSLPEVSYIKPANFMYPDDQSIIGSKRLFRALWERCLVRDKIAICLFMCKRKSIPRYVALVPVEAPDNGEDKNYRSLLCGDGFKIVYLPEAKHIRHLDLQDWNNTENTADEQKVEFFQKIIKKLRVDYQPNLINDPSLDALQANLLALSLDFSTDTKGLDNLLDTSQQDKRIEKLLPDYEMFAPEAEPHKKRAAKSTTAGASGPKMAKIDDDQLKEFEFVKSLNKDEALTSCTAAQLHFILQHHFDVTMPKSSKKAKLVAKIEELHK
The following text describes a protein:
Function:
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Subcellular Localization:
Nucleus.
Sequence:
MRTSLSVVPMQLNFCMSSASTSMSVPSMGGGSPVAETGSYGREGGREGGPLSVNSEALSSHNNPTTTIASAHGTTRGTMFDVTTSFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYQKWMEEQAQSLIDKTTAAFQQGKIPPTPFPGGPPPAGPPRPGMLPTPPMGGPPMMPMMGPPPHGMMPGGPGGMRPPMGAPMPMMPGPPHMMRPPRPMMMPVRPGTHTV
The following text describes a protein:
Function:
Involved in the organization of the Ori region of the chromosome into a macrodomain (MD). It constrains DNA mobility in the Ori macrodomain and limits long-distance DNA interactions with other chromosomal regions. Is part of a system composed of two elements: MaoP, which can act both in cis and in trans, and a cis-acting target sequence called maoS.
Miscellaneous:
MISCELLANEOUS: MaoP belongs to a group of proteins conserved in Enterobacteria that coevolved with the Dam DNA methylase and that includes SeqA, MukBEF and MatP, which are all involved in the control of chromosome conformation and segregation.
Sequence:
MAESFTTTNRYFDNKHYPRGFSRHGDFTIKEAQLLERHGYAFNELDLGKREPVTEEEKLFVAVCRGEREPVTEAERVWSKYMTRIKRPKRFHTLSGGKPQVEGAEDYTDSDD
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MAENVLRGGPEGPDPLTGTTGRGGFCDGTVFHRRVPGFVVRGGDRLGTGHGSAGYRIPDEIRPDQGFEQPFPLAMANLGRDSTGPQFFITLAPAPRLNGQYTIFGQVADERSQDVVRAIAAAPTAVRLDRVTIAADQRSRRRRALWPGGGTAMVTLI
The following text describes a protein:
Function:
Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.
Sequence:
MVGSGRGGWKSLLARCSVVTLDCIPVDFLADEANATTKPKNMNENLVVLYDKYVIPKGKVSDYRTQWSGITKDTYSSNNTGDENSIPIVSFQQCQKEISELLSSIDGKSVVVVGHALDNDFDALEMKHPVALTRDTAFYRPYMRQVRRRMFPRKLSTLSSEVLGIEIQQEPHLIPDDDEGNAIKNSSKIGHSSVEDAATALRLYWHRCLGWERSLRYPLASPQSCDTSTDERHWPALGMYLDGCNLPIGMRGVDFKELLGGKASPETLSYNSVRLVSKHRSNSTSTTVAIVDWIPSFKSVLLPGSLPKITDIVIMFDGAKFRDITSKSKGNRRITDEFHSTTKSFTFESRDNHGSIVLEVTEDGSSADDVLFDRCCKSDGYNTSEYDEQPSTRKIIPLEQAISVLSENRSDLSNDFLSHYIVIRRNGGGSKTHRRLFDKLNLRRPNEGALCLSGITVSHQRDSLKIARELERGRVERVIECELRRRDEVRFIVVTNDVFLAERLTSKGGVLVLSYRQMEHMF
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MDRLTSMAVFVKAVDLGSFAAAADALEMSGPMVGKHVRFLEQRLGARLLNRTTRRQSLTDAGQAYYERCRAVLSAAEAADAVVADELSEPRGRLRVTMPALLGRHCIAPLLMKLARKHSHLELDLSFGDPIADIVEGGYDLAIRTGDLDNQSGLITRRIARQRMVVCGARSYLRAHGKPKSIDDLAAHQAIIYRRSGRVRPWLFPRDGQPPREIMPAGRLRLDDLEAIADAAAQGMGLAWLPCWLVRERLNNGALVGLFGGQPEFLYDCHALWPRSPRMPLKVRAAVDALAAALPKLMP
The following text describes a protein:
Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Subcellular Localization:
Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
Sequence:
MPEGPELHMASQFVNRVCGGVVFSGAVEKSEVSKNPEVPFACTAYRISAVSRGKEVRLTLTPIKDEGAEGGGGKPMDIVFRFGMSGFFRYTAQDELPKHAHLRFYTKEKPGKVLSFVDIRRFGSWEPNGTWQAERGPCVMFEYQSFRDNVLSNLSDRAFDKPICEALLNQKYFNGIGNYLRAEILYRLKIPPFVKARTVLEGLLPRDYAELDVKPVKGGCASPQSPEISLSKKVKLKRESPDLLNLCHTVPLEVIQIGGKGYDPEKADYSDFEAWLQCYYVSGMKSLRDHNGRTMWFQGDPGPMAPKASKSPKAKKRAKKTGDGENDAQVVQEKEPAKKVKEEKESKRKQRRKGKEVQSDRGTPSPVPKRKMSQSRKTPTAGQAGEKFQRSESESRPEPVLNKPAKPVQGTRGPSD
The following text describes a protein:
Function:
Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
Miscellaneous:
MISCELLANEOUS: Using chirally deuterated NADPH, the enzyme was shown to be A-type reductase catalyzing the transfer of deuterium from the 4(R) position of NADPH to the 1' (S) position of the substrate.
Sequence:
MLRVRDDLPPFLKNYLPDGHRNGRPFVTLTYAQSIDAKIAKQRGVRTTISHIETKEMTHYLRYFHDGILIGSGTVLADDPGLNCKWIGPNNDPDESMEEKSPRPIILDPKLKWKYSGSKMEELCNQGMGKPPIVITTKTPKVKEANVEYMIMEPDANDRISWKSILDTLRRNYDMKSVMIEGGSHVINQLLMCSDLIDSLIVTIGSIYLGSEGVTVSPPDEVKLKDISWWKGTSDVVMCSRLQN
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MSDPFGDENIEYTEEFVEGDINEADLVDEHVEYIDENGVSLNSFNNNSNSNTLDFETEDVSNKNNNNNNDYSNDNSSFSAGASHLSPSNRETAPAMKEYLAKHEKELEDKQKASEEKRKKKIAEAKQSLDNFYSEREAKKKTALKNNREHNKTLEGEGTTGGEHSWESVVSMIDLQAKPTPTNKDTSRMKEILLRLKNQPIA
The following text describes a protein:
Function:
Involved in regulation of the phosphorylation of a number of proteins, some of which appear to be important in cell growth control; The M-Pol I complex possesses alpha-1,6-mannosyltransferase activity and is probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins.
Miscellaneous:
MISCELLANEOUS: Present with 4750 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=Cis-Golgi. Recycles between endoplasmic reticulum and Golgi.
Sequence:
MGMFFNLRSNIKKKAMDNGLSLPISRNGSSNNIKDKRSEHNSNSLKGKYRYQPRSTPSKFQLTVSITSLIIIAVLSLYLFISFLSGMGIGVSTQNGRSLLGSSKSSENYKTIDLEDEEYYDYDFEDIDPEVISKFDDGVQHYLISQFGSEVLTPKDDEKYQRELNMLFDSTVEEYDLSNFEGAPNGLETRDHILLCIPLRNAADVLPLMFKHLMNLTYPHELIDLAFLVSDCSEGDTTLDALIAYSRHLQNGTLSQIFQEIDAVIDSQTKGTDKLYLKYMDEGYINRVHQAFSPPFHENYDKPFRSVQIFQKDFGQVIGQGFSDRHAVKVQGIRRKLMGRARNWLTANALKPYHSWVYWRDADVELCPGSVIQDLMSKNYDVIVPNVWRPLPTFLGTEQPYDLNSWMESQEALALAKTLDEDDVIVEGYAEYPTWRVHLAYIRDAEGDPNEAVDLDGVGGVSILAKAKIFRNGVQFPAFTFENHAETEAFGKMAKKMGYRVGGLPHYTIWHIYEPSDDDLKEIASREREKRRQSE
The following text describes a protein:
Function:
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Sequence:
MNRMFDLVLGTGNAKKLVELRMMLPEETIALTALSEIENAIDVVEDGETFSANAAKKATEQAKHLERWVLAEDSGLSVDALKGAPGVYSARYAGTHGDDEANNEKLLRELTDVPMDRRGAQFNCHLCLSDPDGNVRLAESGICRGRIATERSGGAGFGYDPLFVIPEYHKTFGELNLTVKRALSHRSRALRLFIPQLLRLVQSNSTSA
The following text describes a protein:
Function:
Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation and colocalizes with a subset of trimethylated 'Lys-36' histone H3 (H3K36me3)-enriched regions. Binds DNA (in vitro). Facilitates Pol II transcription through nucleosomes. Facilitates male-specific lethal (MSL) histone acetyltransferase complex targeting to active genes on the X chromosome. Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by nej. May have oxidoreductase activity (By similarity).
Subcellular Localization:
Chromosome. Note=Localization to open chromatin depends on H3K36 trimethylation by Set2.
Domain:
The PWWP domain is a H3 reader and strongly binds DNA; In the dehydrogenase domain, the conserved NAD(P)H-binding sites and sequence similarity to plant dehydrogenases suggest that this protein may have oxidoreductase activity. However, since the active site is not conserved, the dehydrogenase domain seems to serve as a catalytically inert oligomerization module.
Sequence:
MSKNKKLSLSGGDTTEKFIYKPKDLIWAKMKGFTPWPGMIVDPPLDLLSQQRRANTKCVFFFGSRNFAWIEENNIKPFEGPWKEELAKVSKPAAFRHAMTDIEKYIDDPAEVDEQVNKSCGAPNHATEADFDKIRDGLDSEEIVGEEATADGNNGVVAHVVGSPDEGDGLDVEINADSSASPVTSPAVTTKAAGKRTPKAKSVAATSVKSTKGSAKSAQKRRTSAQQSPSGPSNAKRGKRDVSGEALQDADEASSTPTGRRRVETDALLASIAAKRAPNAIALLDRPVVTRPEAQVIDMSSRSNTLADRDIVPSEQTFGFLGLGMMGSTIVKDLIYTGHKVVVWNRTIDKCQPFAEAGAEVKDTPMDVVEAADVIFCCVSDPKGAKDLVFGNCGVLQLKDLNNKAYVEMSTIDPDTSLDIGEGIKQCNGRYLEAQIHGSRQEAAEGMLIILAGGDRSVFEECHSCFKTIAKNTFFLGNIGNACKVNLILQTILGVSLVGLAEALALADRFSISLNDIIDIFDLTSMKSPMLLAKGKEMAKGDFNPQQPLSHMQRDLRLVLNMAENLDQSMPVTSITNEVFKHTKRLGYSEHDSSAVFVRSRF
The following text describes a protein:
Function:
Fatty acid desaturase that introduces a cis double bond at the 4-position in 22-carbon polyunsaturated fatty acids that contain a Delta(7) double bond, resulting in the production of delta-4 desaturated fatty acid docosahexanoic acid (DHA) (22:6(4,7,10,13,16,19)).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The cytochrome b5 heme-binding domain acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome.
Sequence:
MTVGYDEEIPFEQVRAHNKPDDAWCAIHGHVYDVTKFASVHPGGDIILLAAGKEATVLYETYHVRGVSDAVLRKYRIGKLPDGQGGANEKEKRTLSGLSSASYYTWNSDFYRVMRERVVARLKERGKARRGGYELWIKAFLLLVGFWSSLYWMCTLDPSFGAILAAMSLGVFAAFVGTCIQHDGNHGAFAQSRWVNKVAGWTLDMIGASGMTWEFQHVLGHHPYTNLIEEENGLQKVSGKKMDTKLADQESDPDVFSTYPMMRLHPWHQKRWYHRFQHIYGPFIFGFMTINKVVTQDVGVVLRKRLFQIDAECRYASPMYVARFWIMKALTVLYMVALPCYMQGPWHGLKLFAIAHFTCGEVLATMFIVNHIIEGVSYASKDAVKGTMAPPKTMHGVTPMNNTRKEVEAEASKSGAVVKSVPLDDWAVVQCQTSVNWSVGSWFWNHFSGGLNHQIEHHLFPGLSHETYYHIQDVFQSTCAEYGVPYQHEPSLWTAYWKMLEHLRQLGNEETHESWQRAA
The following text describes a protein:
Function:
Glycosidase that specifically hydrolyzes the Man-beta-1,4-GlcNAc linkage in the trimannosyl core structure of N-glycans. Does not hydrolyzes pyridylamino derivatives sugar chains containing Man-alpha-1,3-Man-beta or Xylose-beta-1,2-Man-beta.
Sequence:
MAEIGKTVLDFGWIAARSTEVDVNGVQLTTTNPPAISSESRWMEAAVPGTVLGTLVKNKAIPDPFYGLENEAITDIADSGRDYYTFWFFTKFQCQRLLNQYVHLNFRAINYSAQVFVNGHKTELPKGMFRRHTLDVTDILHPESNLLALIVHPPDHPGTIPPEGGQGGDHEIGKDVAAQYVQGWDWICPIRDRNTGIWDEVSISVTGPVRIIDPHLVSTFFDDYKRAYLHVTAELENKSTWNTECSVNIQITAELENGVCLVEHLQTENVLIPAQGRIQHTFKPLYFYKPELWWPNGMGKQNLYDILITVVVNEFGESDSWMQPFGFRKIESVIDSVTGGRLFKINGEPIFIRGGNWILSDGLLRLSKERYRTDIKFHADMNMNMIRCWGGGLAERPEFYHFCDIYGLLVWQEFWITGDVDGRGVPVSNPNGPLDHELFLLCARDTVKLLRNHPSLALWVGGNEQVPPKDINEALKQDLRLHSYFETQLLSDKDSDPSVYLDGTRVYIQGSMWDGFADGKGNFTDGPYEIQYPEDFFKDTYYKYGFNPEVGSVGMPVAETIRATMPPEGWTIPLFKKGLDGFIKEVPNRMWDYHKYIPYSNPGKVHDQILMYGTPENLDDFCLKAQLVNYIQYRALFEGWSSQMWTKYTGVLIWKNQNPWTGLRGQFYDHLLDQTASFYGCRSAAEPVHVQLNLASYFVEVVNTTSKELSDVAIEASVWDLDGNCPYYKVFKIVSAPPKKVVKISEFKYPKAANPKHVYFLLLKLYTVSDKAVISRNFYWLHLPGKNYTLLEPYRKKQIPLKITCNAVMVGSRYELEVNVHNTSRANLAKNVVQEDEKRDLGLLQKLFSRCVVSADSNRGLKVVEMKGSDSGVAFFLRFSVHNAETEKQDTRILPVHYSDNYFSLVPGESMSFKISFAAPTGMKKSPRVMLQGWNYPDRFSVFG