lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7. Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal. PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5; Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome matrix.
Sequence:
MAMRELVEAECGGANPLMKLAGHFTQDKALRQEGLRPGPWPPGAPASEAVSVLEVESPGAASEAASKPLGVASEDELVAEFLQDQNAPLVSRAPQTFKMDDLLAEMQQIEQSNFRQAPQRAPGVADLALSENWAQEFLAAGDAVDVTQDYNETDWSQEFISEVTDPLSVSPARWAEEYLEQSEEKLWLGEPEGTATDRWYDEYHPEEDLQHTASDFVAKVDDPKLANSEGTSDAWVDQFTRPVNTSALDMEFERAKSAIELQAELEEMAKRDAEAHPWLSDYDDLTSATYDKGYQFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTNESLQRQACETLRDWLRYTPAYAHLV
The following text describes a protein:
Function:
E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways. E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.
Subcellular Localization:
Cytoplasm.
Sequence:
MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSAFPLDAILNARRAARPCQAHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFEELQRELKEQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSGGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI
The following text describes a protein:
Function:
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
Subcellular Localization:
Nucleus.
Sequence:
MSRRKQSNPRQIKRSLGDMEEGEDNQAEDISQSEQEGDASDPEASAEGDALSSPGSIELEAKEVLESPKDPEKQEPDKGPKEADPWNGPDELELILVEGESRVRARRSLPEGLCWGPFSGNIQSEQASPGQGEPSPPLTLLLGDEHCWLTRLPLVSSEAEANSVIYRKEEAVWCKTTKPVSGDELMTTFIMAEPQGIPNHTVKTEPGDPTYPVTLHSDIQLLPQQAGMAAILATAVVNKDVFPCKDCGIWYRSERNLQAHLMYYCASRQSSSSPSPSAEEKPKDTYPNERICPFPQCKKSCPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLNGVCHSCGFVSTTRDILYSHLVTNHMICQPGSKGELYSPNSGLPATKPAPPGLAQGSITPILKCSLPSLTADSLPGLQQHVVPHGPPVAPTPGPAPLQPESPPAALDPVGRRPRAEMENGDTPGEGCSSASSSAGEEAVPAMSIKRELEESHGTGPEGTKSRRPGEPGPSSRTPSPHSPPLVKVKSELASPTPGSSPVPSEPCPGHAGGTVFLPQYLFSPEASVVPQASEILAKMSELVHSRLKQGHGGGGGPPALFAGTPVPKGATCFECEITFNNINNYYVHKRLYCSSRHLPEDGPPGTRKPKSAAPRGSPGAAPARALLSPQPPEGQGAPTPPDGGDEGGARSPPGPEARAEEGGRAKGASPEADGAGRGSEGSQSPSSSVGDPDDDPTKTVCEACNIRFSRHETYTVHKRFYCASRHDPPLRRPGSASKVAFLPQPVRTRKRRKLYEIHAAAVATTATPGPALLPAPLHHHRPQPPGADPAATTASPQRGPGPADPPGVGARPDGPPAPLPGAPAPASAPSPGSGPDAEGPIDLSKKPRLRGGEVQPAAPPPPPLLPLADYHECTPCRVSFHSLEAYLAHKKFYCPAAPLQQSTLEQLHKIKSLPRLRPAGASAQGFSGEEPEGPPGARVKVEKGAGPAKAPSLPAAFPAGDALQRYLGPKALHLSGGKAPPLVVCPYCPLNGAVKGDLIEHFRHAHGLFVAQPVAGHVLAEASGPLARTPAGSGAENSLPAPLPLPPLASSSTVSSSSSSSSSSSSSSSSPQPGPRLPRDSFNGQDPKEPPISSNGSPMPAGSPRPVLPLSPTGPSLPLSPVPEAPLLKPPTPPVFTDKSAQPPPAKSLPASAPNGNHRYCRLCNIKFSSLSTFIAHKKYYCSSHAAEHVK
The following text describes a protein:
Function:
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase.
Subcellular Localization:
Nucleus. Note=Observed in the nucleus during prophase and metaphase.
Sequence:
MNSVLSNIEKLDTYILRRNEYVAESKDEPNKLNTSRKLEVTTKKNQSNNKKRPPPINKARKSLPSIFRRAEENKDSAQIITPTGSKIIGSPLYKRSKSDSFFDHAFNFDKNLGKGSFGEVVAATCRSTSKKFAIKKIPFSKLSKDQYREAYGHMNIPCHPNIVRFHQAWIDKQILHIQLEMCDKSLAAYCHGIDWLEDKELWNVFLDILQGLGHLHNNFMLHNDIKPDNIFMTKNKVCKLGDFGLISDMRSEPINNSSNKHYQSEGDGKYCSKEAINGTLSIFSDIFSFGISILEVGTNIHLPSYGTGWEPIRKWEIPEEILEPMSDELRELVKQMMDKAPTRRPTCSELMKNHVVKEKLRIRKQEVEHIPSESQFQPISYLTTESPLGSRESSCSSIDFLDHFENAEKKTPFVSKLNFDLEDDEDEYEVFSPPRTPVKKSRYQQTMPEVSPPRKIQKLFQRKNLFDE
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MLPFSGEQQRLSAHTVTLLTLCFTTILRLAKPSTNGFNEAKITQLCGTAMAIQDTAAVAIGRLQKLHRQEQAAAEARNKLLLAALVVPTVNDTILFTAAARAAENCRVDATTKAAGNVAAGVTAAANGAHVAGRLTELVAILQATTKSDTARKCITQANTRTTKLTSPAEFGCPTTITDEYAPKLNLDSSEITNKGLAKYSGPTQLQDATGNNVCAFMLGSNADNTALWQYSGSATPATVGADLITVSPHTGSGATATIAVANALGTDYQAPDSATAAKKLFTAIGKVMKLPESTCPETTEKAISEALTTTTIKAEVKDLLIKLGKVTNTMADQAARSLIGQAVKDDNAASTARVNQVNKLKVKKIDGGKPKEVKIETLTDPPEITTALLIAIPELKAKADRTVASEPAKDCSTNGGIQEENKECSKKTGDDCKDGCKLTGEGENKKCVKDTYFVKKEVEGGEKDSKTGTTNTTGSNSFVIHKVPLLLAFLLDFINL
The following text describes a protein:
Function:
Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface.
Subcellular Localization:
Golgi apparatus membrane.
Domain:
The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.
Sequence:
MEKMTTLKSFESKGILTSTPIRGAGDGMETEEPPKSVEVTHGVQPINQHVLPSPRKKVPSDSPGVLQLGKILNEKTVEVEAVRIFVPKAAITHDIPTKSAKVKSLGHHREELHNQSEVVTDPRKELSEVKKVLEKLKNSERRLLQDKEGLSNQLRVQTEVNRELKKLLVASVGDDPQYHFERLAREKNQLILENEALGRNTAQLSEQLERMSIQCDVWRSKFLASRVMADELTNFRVVLQHQNRDAQSAIQDLLSEREQFRQEMISTQKFLEELLVSLQWGREQTYSPNTQPHSTADLALTNHRLAEAVHAHLLGNVGISHPKRTPATAEVCSTPAEKMAEKVLRILDPVACTESSPDNAFAESTLLTTKKNIGRFHPYTRYENITFNCCSHCQGELLAL
The following text describes a protein:
Function:
Class I viral fusion protein (Probable). Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. During viral entry or virus-mediated fusion between infected cells and neighboring susceptible cells, the head domain of the H protein initially binds to its receptor and then the stalk region of the H protein transmits the fusion-triggering signal to the F protein. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity); Some hyperfusogenic isolates can induce membrane fusion in SLAM- and nectin-4-negative cells and are linked to fatal subacute sclerosing panencephalitis (SSPE) or measles inclusion body encephalitis (MIBE). The neuropathogenicity is closely associated with enhanced propagation mediated by cell-to-cell fusion in the brain, which is principally regulated by hyperfusogenic mutations of the viral F protein. Cell-to-cell transmission of the virus also occurs with hyperfusogenic isolates.
Subcellular Localization:
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein.
Domain:
Contains 3 heptad repreat regions, HRA, HRB and HRC.
Sequence:
MGLKVNVSAIFMAVLLTLQTPTGQIHWGNLSKIGVVGIGSASYKVMTRSSHQSLVIKLMPNITLLNNCTRVEIAEYRRLLRTVLEPIRDALNAMTQNIRPVQSVASSRRHKRFAGVVLAGAALGVATAAQITAGIALHQSMLNSQAIDNLRASLETTNQAIEAIRQAGQEMILAVQGVQDYINNELIPSMNQLSCDLIGQKLGLKLLRYYTEILSLFGPSLRDPISAEISIQALSYALGGDINKVLEKLGYSGGDLLGILESRGIKARITHVDTESYFIVLSIAYPTLSEIKGVIVHRLEGVSYNIGSQEWYTTVPKYVATQGYLISNFDESSCTFMPEGTVCSQNALYPMSPLLQECLRGSTKSCARTLVSGSFGNRFILSQGNLIANCASILCKCYTTGTIINQDPDKILTYIAADHCPVVEVNGVTIQVGSRRYPDAVYLHRIDLGPPISLERLDVGTNLGNAIAKLEDAKELLESSDQILRSMKGLSSTSIVYILIAVCLGGLIGIPALICCCRGRCNKKGEQVGMSRPGLKPDLTGTSKSYVRSL
The following text describes a protein:
Function:
Transcription factor that plays a role of activator of filamentous growth and which is involved in invasive growth at a high temperature. Required for human oral epithelium colonization and damage. Promotes filamentous growth in EFG1- and FLO8-dependent manners. Antagonizes functions of SFL1.
Subcellular Localization:
Nucleus. Note=Localizes to the nucleus in both yeast and hyphal cells.
Sequence:
MSKKNPGDPRVKKNAFVHKLYTMLHDPALSHLIWWTNRNGEQNTFALCPGKEFADCLTQYFKHGNVASFVRQLHMYGFHKVSDPLPITYPPNGNNNNNNNNKEVPPVWEFKHSSGRFKRGDETSLVYIKRRSSSNHTSGSTIYAEPIYNPLLTNPYNQPQFMYQDYSMGPPVEVQQFYNYQNQPLMYYQQPPGQVPPPPPPSLPPHQQPEMALQYHQYNNYQQPPPAPPAPPPQPGNVLFGYQQVAPPQQPGSTVQQIPANAPPTLDQTQPLSYTPQLEYQQQQYPQPPLPPPPPQLQLQTSPGIPKVNDNLSRPSPNEQHLQFRKIWPDENNEANSKPRNPSLMFDPLLRVNSEGSPKTQPNHSVSLLNNEVRSESSTSSSSTTVTSTALPPPSAIDRSVSLVGGSPFDLSSRMNNQQSFNRTPSISTPPTQNGRLPKISSPLIPSNTESQSPTMVTGTDNDVGVTSKGSTSIISVSKKPSVFSNSLQERLRPSMFEYHPIGNNLSKDVLTIPKISTNSNSGSRTTSQSSMSSASALSSKKSSLSSISSTHGNLSILNSTNYRSTSVGGSGSGPFSTSTSTSTTSPTLSSLLHHPQHEPQNSTIANGTSIRSSISSSQSISSPPLTTTTTTTTTDQRQLSNSPISRQQQQQPNNNTNKKVSVTSLLLPSHSQSQGYAQPLYKSSVIAEEENSTTSSGGGYRSKSDDDTDNMNK
The following text describes a protein:
Function:
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRILVTGTPGVGKTTLAKRFLELHPDYRYVNVSDLVHSSGLIESYDEVFNSVVPDEERLLDTLEVLIQRNKNILVDHHSCERFPIRWFDIVVLLRLGTEELYDRLVLRGYSSKKILENIEAEIMGVAEDAVADFDQRRVITFTHKTEDDMRHVLARIEERLHQTPRSVRLKGSKTRLCVCRPQRCYAWTWHGSISSFCKAYRNSLRFRSSGGERKK
The following text describes a protein:
Function:
Prevents non-specific action of the splicing factor CFM3b during plastid rRNA biogenesis to improve the accuracy of plastid rRNA processing. Required for plastid functions such as photosynthesis, intracellular distribution, plastid rRNAs biosynthesis and plastid gene expression in roots. Involved in a sucrose-conditional process important for the organization of root lateral and apical meristems (e.g. establishment of RAM from pericycle and symplasmic connectivity), and subsequent primary and lateral roots development. Modulates C18 unsaturated fatty acid metabolism (Ref.6).
Subcellular Localization:
Plastid, chloroplast. Plastid. Note=Present in root plastids and chloroplasts in leaves.
Sequence:
MESLLHASSSLVSLRPRIDGRDSFINPSRVCLNPSLGRRGSKPLPLVAAAKKKKSKKDDNHNFSARPDEATGPFPESILLKEKKIDEEGDLLPEFADAEEKELYQFLDLQLQSDLNEERMRHYEVVYLIHEKHAEEVESINQKVQDYLKEKKGKVWRFSDWGMRRLAYKIQKAENAHYILMNFEIEAKYLNEFKGLLDSDERVIRHLVMKRDEAITEDCPPPPEFHSVRAGDEYYDDDEEEEIEEDEDEGEGEDEEDADNIEYEVDDDGNVVMVLYGDEEEGEEEEDGASEQEEGQDKSTNGRRETRRTVNVGG
The following text describes a protein:
Function:
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.
Sequence:
MLNFLRSFWRIKRPSTMEPLIAVVGATGTGKSKLAVDLATRFNGEIINGDAMQMYRGLPIITNQIPFEERNGIPHHLISCVDFEEEPWRIGHFKRECLRLIKDIHSRGKLPILVGGTHYYTQTVLFKDQLVEESLFSGDDDDAHFHKETKPTSAKWPILDAPPDVVFQKLKEVDPVIASRWHPNDVRKIRRSLEIYFQTGKPASEIYAEQKRQKYATGTNGESSPGIGQLRYPTLIFWVHSEKETLNCRLAKRVDSMVEQGLMAEAQRMWAYIREKKGQGITVDQTRGVWVSIGFKELAPYFDALENGELSEGELEALKQSSIELVKIATRQYATSQIKWIRNKLWKALADAGATKNLYLLDSTNVEDWQRWVTEPSEHLTQALLNDEPRPDPKSLSDMARETLCAREVQAQTQRSDVLQTFTCEICSRTMATQDQWNIHLNGRAHKRAIKNAAKRAEREKYLRNQQTLGVGQNCDNPTPTEQPSTPQ
The following text describes a protein:
Function:
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Subcellular Localization:
Mitochondrion. Nucleus. Cytoplasm.
Sequence:
MSLMFLRRAGNIKGRNIRFALQRGSVGYSQQSSEACKNFLNTTQLRTMVQTAALHGPKPMDSSHIKVTNVKELKPLPEWKSLKFGENFTDHMLIMKWNREKGWSTPEIVPFGKLCFHPASSVFHYGFECFEGMKAFRDEKGVPRLFRPIKNAERMLSTGTRISLPSFDPAELAEIIRKFVAHENRWVPDQRGYSLYIRPTFIGTDEALGVHHCDNAMLYVIASPVGPYYSSGFKAVKLCCSEESVRAWPGGTGHYKLGGNYAPSVLPQKEAAKKGYAQILWLYGDEDYITEVGTMNCFTVWINKNGEKEIITAPLDGMILPGVTRDSILEICRERLAPKGWKITEGKYSMKEVAQASKEGRLLEVFGAGTAALVSPVKAINYKGTEYEIPMPEGQEAGPITSEISKWILDIQYGKEPNNPWSVPALP
The following text describes a protein:
Function:
Catalyzes the exchange of ADP and ATP across the membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDHDQLYDSPQSAKDSLLDMTALLIVTFAQRAVMAPSYRVTLLATVEGELVREGRLPPKGFGGVFGCIKRLYVKEGVRSFFRGLLTDAVLSLPATVVENISSTLVSFALQVAIPVRLVESMNPWTYLTLSLSSTSAAVLLATPATGLHSTIVTNYVADIVAPVPSEKSKNPDKDDGENNKEIKEGEKGGEESYRYATATEAVASIFRRWGFSGFYRCIGADAIAVFLYRGTYYYGLQLLPSTLHNRFPYGISRCLAVVAGFLTQPFEVVSRRMQLTASSTTGRRYKGMLHCARTIVAEEGYTALWAGMQARLLVTCVGVAVLELHRHFWAV
The following text describes a protein:
Function:
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular Localization:
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton.
Sequence:
MLPFSCYSVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQALIINAYPDNITPDTEDPEPKPMIIGTNNVFEVGCYSQAMKMGDNNVIESKAYVGRNVILTSGCIIGACCNLNTFEVIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKTMKGSSTPVKN
The following text describes a protein:
Function:
Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
Sequence:
MLLPGSRLGVMGSGQLARMFCLEAIPFGYEISVYSPEKNSPAAGAGAKEYISTYEDEKALTFFLENIDGLTFEFENIPEIALTTIENFSKRTGLIVRPSPNCVRISQNRWKEKTSFQKAGIPTVKFYPVLTEEDKKSVLSKTNFPCILKTNTMGYDGRGQIRCITEQELSLVFSNLNKPDHIVEEFFQFTSEASVIMARFEDGKILNFRPSKNVHKNHILDLTFYPGNFPDSIETKLVNYAKKLAETIDYVGVFGIEFFIRGDEILCNEFAPRPHNSGHFSQNSGTISQFSLQLRTLCNLPSPKTILANPVSMKNILGEDYKPGSTLWNKTLENPYYHLHLYGKTEIRNGRKMGHWNYSGPNIESAFLNWD
The following text describes a protein:
Function:
Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
Sequence:
MKNNAKEDYRTFSLTTNYSRQMIYRCVTGLQIGFSLFSFIIVCVALPIMYNHVQNTITYVDREMAYCEVRFLYFYCIKFFSTLQRSNDEAALELQYGKMRMTGNRTARGAYGSGASHGFRPTAYGDEITGAPLETECPGCCIPGPPGPRGSSGTPGKPGLPGNAGKPGMPGTTPNQTCPLNQVREPPPCRPCPKGPPGIKGWPGFPGDVGPPGPPGLKGIDGEDGAPGETGPTGPPGYRGGPGAPGDKGPTPEGDLKEGPPGDEGPPGPIGAPGMPGLPGRNGLTGGQGERGWPGVSGESGEPGYPGPEGPMGGQGPPGEPGVCVCQNVDSILLINPGPQPRIRADDYNSDDGYGGSRGGGDRAGYQGYGRK
The following text describes a protein:
Function:
Involved in endocytosis and clathrin cage assembly.
Miscellaneous:
MISCELLANEOUS: Present with 6800 molecules/cell in log phase SD medium.
Subcellular Localization:
Bud. Bud neck. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Sequence:
MSSLYTKLVKGATKIKMAPPKQKYVDPILSGTSSARGLQEITHALDIRLSDTAWTIVYKALIVLHLMIQQGEKDVTLRHYSHNLDVFQLRKISHTTKWSSNDMRALQRYDEYLKTRCEEYGRLGMDHLRDNYSSLKLGSKNQLSMDEELDHVESLEIQINALIRNKYSVSDLENHLLLYAFQLLVQDLLGLYNALNEGVITLLESFFELSIEHAKRTLDLYKDFVDMTEYVVRYLKIGKAVGLKIPVIKHITTKLINSLEEHLREETKRQRGEPSEPQQDRKPSTAISSTSSHNNNSNDKNKSIAQKKLEQIREQKRLLEQQLQNQQLLISPTVPQDAYNPFGSQQQDLNNDTFSFEPTQPQMTAQVPQPTANPFLIPQQQQQALQLTSASTMPQPSEIQITPNLNNQQTGMYASNLQYTPNFTGSGFGGYTTTENNAIMTGTLDPTKTGSNNPFSLENIAREQQQQNFQNSPNPFTLQQAQTTPILAHSQTGNPFQAQNVVTSPMGTYMTNPVAGQLQYASTGAQQQPQMMQGQQTGYVMVPTAFVPINQQQQQQQHQQENPNLIDI
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MASSSSVQSSSAQWYPPSPGGLKLVEALTRPKDDLFDNSTMTFGEHLEELRGSLVKAIIWLLIGLAVGLMFANRVVRFIQEPLKQAIIEYNADRDLKEMGLPDRKEDPQVSRFYEFLTSNSLVADVVYTLPSGSVPVATGDMVEPPEATGTAVESEPDEKNSPDVEAEAGESAALDIPERITTAELMKSMGTIPNPDELVPMIQLRRSERGLSSLKIEEPFMIWVKAGLIVGAVLASPMIFYHLWSFVAAGLHSHERRYVYVYLPFSVVLFVSGVVLAFGLVLHYVLTFLLQFNGSMDVAVEPRLTYYVNFVLMLPLGFGVAFQLPLVMLFLQRIDLIQTQDYINSWRVAVLVIFVISMIVTPADVTSMVALAVPLLFLYFLGIVMCAYMPRGRGLGSEAYDPA
The following text describes a protein:
Function:
May activate progelatinase A.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MLRLLALLLPLLQPPARAREPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPAKLRDAIKVMQRFAGLPETGVLDPLTVATMHKPRCSLPDVLGAAGLVRRRRRYALSGSVWKKRTLTWRVNSFPQGSGLSQETVRTLMHHALTTWGAESDLRFQEVGSQGPTEPDILIDFARAYHQDSYPFDGQGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPDSIMRPFYQGPVGNPAEYRLSQDDREGLQQLYGRAPQTPYDKPTRKPLAPPPPPPALPPDSTPQPLPDRCDGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPTQVKVIQAAYARHPDGRILLFSGPQFWSFQDRLLEGAARPLTELGLPPGTEVDAVFSWPLNGKTYLIRGRQYWRYDEAAARPDPGYPRDLSLWEGAPSAPDDVTVSNTGDTYFFKGLHYWRFPKGSIKAEPDSPQPMGPKFLDCPAPTVGPRAPRPPRATLKAGDCDCQCGISRAAGRPSVLLLPLLSLLVGGLASP
The following text describes a protein:
Function:
Receptor for prostaglandin E2 (PGE2). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKETRGDGGSAPFCTRLNHSYPGMWAPEARGNLTRPPGPGEDCGSVSVAFPITMLITGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSKQRWEQLDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTIQWPGTWCFISTGRGDNGTSSSHNWGNLFFASTFAFLGLLALAITFTCNLATIKALVSRCRAKAAASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTDTGKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQVIHENNEQKDEIQRENRNVSHSGQHEEARDSEKSKTIPGLFSILLQADPGARPYQQ
The following text describes a protein:
Function:
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (By similarity). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (By similarity). Within the MRN complex, XRS2 acts as a protein-protein adapter. Specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (By similarity). Recruits MRE11 and RAD50 components of the MRN complex to DNA damage sites in response to DNA damage. The MRN complex is also required for the processing of R-loops.
Miscellaneous:
MISCELLANEOUS: Present with 358 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome. Chromosome, telomere. Note=Localizes to DNA double-strand breaks (DSBs); recruited to DNA damage sites.
Sequence:
MWVVRYQNTLEDGSISFISCCLQAFKTYSIGRSSKNPLIIKNDKSISRQHITFKWEINNSSDLKHSSLCLVNKGKLTSLNKKFMKVGETFTINASDVLKSTIIELGTTPIRIEFEWINEVWNIPPHLTQFRTMLSEYGISTEISINDIPANLMISDYPKSEDNSIRELYALVSTIPMKKSRFLMELCNTLLPTSKTNLKFDEMWNDMISNPEYNVFDFDPNILLSKFMRLNNIRVLTTIKSEPRLSSLLRTFNINLFAFDNIDSLYKYVDSLEASTEYLILTTTDKKENGKILCTIKTMLTSIIDGTLSAVINMKGASSRTLDNGKFDQISEGMSTILKTSRAPEVEASPVVSKKRKLNRRRVLPLDSLDFFAGGLSTKTLSENRSLTDAKRLNCGAESKTVISSPNIAEADEKHAPFLQNALKPTEDIGKKSGHSSPGAIIVSSPNLGTVNTSEDSLDKSLQSHKLPQPSLPEVAGIGSQTISSNSADYETAAVNSMDDAEVTKNFRVNHHQNIEQPSKNIRKLSNYSREISSPLQENCKSPVKELSIKEKSGTPHAFVEAIQETKNREVKRVKSTIVELKDEELSEEAINQLKNLAIVEPSNNLLRKSFDSEGNKTSRTTEKWENSLMEPEWHKRKNFKTFVKVRPKSKAHKEEGKNNTQSSDFIRNAAFLITRNYVPLKKYSKKDTTTKWGTEENEDMFALTEMERFGSNTFMSDNINSNTIQKRSQALNRFTNEDSSNEGEEDSFSFSRCSGTAASVQPLKNKIFITDEDDLGDIDDKSDRLNHRENNRNLFVVKEMNLRPNLSEECSKQSRHSRSATSRSRGSFGASNNGDGDDDDDDGPKFTFKRRKG
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MATDWRLPKAVCAEAEVPFTTEESDDEGEPSDPKEPELPAEFKTLWEEATENPYNFNGWAKVLEYVETMNNLVAGRKVYDAFLTRFPYCYGYWKKYADLELQLRNTAETEEVYCRALQSIPLSVDLWINYITFLKNTLDTALPESIEKLQGAFRSAAAAAGMEFRSDKFWEMYIDWEIKQGNFREATAVYDQVLSIPTQLYRQHHERFKQHISAHAPHELLREEEFKWICSKIKAEGENDQIAAEDSPSGDDQENPVDVTDPELQSKVKAQVLIIREQLFLLNEAEVRKRWSFEEAITRPYFHATPLDRTQLQNWRKYLDLEISQGRHERIVTLYERCLVACALYEEFWLSYVQYMEPHSIEAARCILQRACCIHLPLKPTLSLYWAAFEEKHGQIDTARSVLYDLENLMPGLAMVRLRRVSLERRTGNLEEAEHLLEEAVKSSLGTELAAFYSVKLARLLLKLQGNMEKARKVLTEALEKEPDNPRLHLCLLEIEVSREGSQGEADALLCVERALKSSLSDDFKKMISQRRLEFLEDNSSNITSVLSAYDEHQKFLKQEELKRQAENGSEDETEEKKPKTETVVHISAPPVHVNRNTLHPRPMNYNTLLPTPTVSAPPYRPMLGAHYRAPAYGYGPWYQNYSAYNPPPWNYNRFYQPH