lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEDDDDDI
The following text describes a protein:
Function:
Olfactory receptor specific for trace amines, such as beta-phenylethylamine (beta-PEA). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors. Beta-PEA-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
In addition to the well known disulfide bond common to G-protein coupled receptor 1 family, trace amine-associated receptors (TAARs) contain an unique disulfide bond (Cys-22-Cys-186) connecting the N-terminus to the extracellular Loop 2 (ECL2), which is required for agonist-induced receptor activation.
Sequence:
MSSNSSLLVAVQLCYANVNGSCVKIPFSPGSRVILYIVFGFGAVLAVFGNLLVMISILHFKQLHSPTNFLVASLACADFLVGVTVMPFSMVRTVESCWYFGRSFCTFHTCCDVAFCYSSLFHLCFISIDRYIAVTDPLVYPTKFTVSVSGICISVSWILPLMYSGAVFYTGVYDDGLEELSDALNCIGGCQTVVNQNWVLTDFLSFFIPTFIMIILYGNIFLVARRQAKKIENTGSKTESSSESYKARVARRERKAAKTLGVTVVAFMISWLPYSIDSLIDAFMGFITPACIYEICCWCAYYNSAMNPLIYALFYPWFRKAIKVIVTGQVLKNSSATMNLFSEHI
The following text describes a protein:
Function:
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.
Sequence:
IASSSMLARHVILIVCSVSVVRCYNSLPWEHINIAEHQRPCLQHKFNQTKKDKPKCWGYEAGCDELSRYEPRWPRDCETHELWRFWEQGDFGYVRNRLNELEQLQICKPRKNDVTKSSMNCTGRLQFCQARDIFLDLRHPRSTKWPRHPDDVLMADEVGGNCDVDKEALSRQYTQGLNGGLRAWYSELRHFTDVTDPQCDLFIDKPVVFMKLDQGNNMYHKFCGFFNLYISMHVNGSLDFNDDFMIINWDWSNVPYNNYFEASWSAFSKHQVGHIRDWFGKRVCFKSAVFSFLPRMLLGLFYNAMLGENCSGSGMMKSFSQFFLHRMNVTQKGPIPGKIRVTFLQRSTKPDYLGKVYRQIVNEKDLFKVLNNIPGFQVKVVEYHQDTMSFKDQISMSHNSDIMIGMHGAGLTHFLFLPPWAVAFELYNCQAKCYRDLARLRGVRHMTWSRDDKLTTHNARERERDPENRRYWNFSFDLEEFRRLVLEARDYVLQELGRVHTEL
The following text describes a protein:
Function:
Required for DNA damage induced mutagenesis. Involved in DNA repair, mitochondrial DNA repair and translesion synthesis. Has a role in the bypass of abasic (AP) sites.
Subcellular Localization:
Mitochondrion.
Sequence:
MNRWVEKWLRVYLKCYINLILFYRNVYPPQSFDYTTYQSFNLPQFVPINRHPALIDYIEELILDVLSKLTHVYRFSICIINKKNDLCIEKYVLDFSELQHVDKDDQIITETEVFDEFRSSLNSLIMHLEKLPKVNDDTITFEAVINAIELELGHKLDRNRRVDSLEEKAEIERDSNWVKCQEDENLPDNNGFQPPKIKLTSLVGSDVGPLIIHQFSEKLISGDDKILNGVYSQYEEGESIFGSLF
The following text describes a protein:
Function:
Possesses E3 ubiquitin-protein ligase activity when associated with the E2 enzyme UBC8 in vitro.
Sequence:
MGLPTDFKELQIPGYVLKTLYVIGFFRDMVDALCPYIGLPSFLDHNETSRSDPTRLALSTSATLANELIPVVRFSDLLTDPEDCCTVCLSDFVSDDKIRQLPKCGHVFHHRCLDRWIVDCNKITCPICRNRFLPEEKSTPFDWGTSDWFRDEVESTN
The following text describes a protein:
Function:
May play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage. Can resolve the topoisomerase II (TOP2A) DPCs (By similarity).
Subcellular Localization:
Nucleus. Nucleus, PML body. Chromosome. Note=Co-localizes with SUMO2 at PML bodies in all interphase cells. Localizes on condensed chromosomes in spermatocytes in G2 and M during meiotic prophase (By similarity).
Domain:
SUMO interaction motif 1 (SIM) mediates the binding to polysumoylated substrates.
Sequence:
MDGCKKELPRLQEPEEDEDCYILNVQSSSDDTSGSSVARRAPKRQASCILNVQSRSGDTSGSSVARRAPKRQASSVVVIDSDSDEECHTHEEKKAKLLEINSDDESPECCHVKPAIQEPPIVISDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPDDSSDDSDVPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEASDDSSDDSEASDDSSDDSEAPDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAEDLCNEGQIASDEEELVEAAAAVSQHDSSDDAGEQDLGENLSKPPSDPEANPEVSERKLPTEEEPAPVVEQSGKRKSKTKTIVEPPRKRQTKTKNIVEPPRKRQTKTKNIVEPLRKRKAKTKNVSVTPGHKKRGPSKKKPGAAKVEKRKTRTPKCKVPGCFLQDLEKSKKYSGKNLKRNKDELVQRIYDLFNRSVCDKKLPEKLRIGWNNKMVKTAGLCSTGEMWYPKWRRFAKIQIGLKVCDSADRIRDTLIHEMCHAASWLIDGIHDSHGDAWKYYARKSNRIHPELPRVTRCHNYKINYKVHYECTGCKTRIGCYTKSLDTSRFICAKCKGSLVMVPLTQKDGTRIVPHV
The following text describes a protein:
Function:
Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.
Sequence:
MPLQLNLLQAVDQPHPVAFKPNNCSTHQPQHSPSTQNNGKSARANRRRRRRRNKQQQNSQQPDAFRDTDAQLTPSTSSSTPHSAPNDRQDHLNSQFNPESINMPARFAEEVITAEPAQRAAPQLDLGGGHYVPRQQHLNDEIAITGFSGRLPESSTIEEFKQNLFDGVDMVNDDPRRWERGLYGLPDRIGKLKDSDLENFDQQFFGVHQKQAECMDPLLRMLLELTHEAIIDAGLNPSDLRGSRTGVYIGVSNSETEQHWCSDADRVNGYGLTGCARAMFANRISFTFDFKGPSYSIDTACSSSLYALEQAFSDMREGKVDNALVAGAGLILKPTMSLQFKRLNMLSPDGSCKAFDESGNGYVRSDGCVVLLLQRTSAARRVYASILNVRTNTDGFKEQGITYPIGKMQNRLIRETYEEIGLNPADVVYVEAHGTGTKVGDPQEVNSITDFFCKDRTTPLLIGSVKSNMGHSEPASGVCSVAKILIAMEEGVIPGNLHYNKPNPDLYGLVDGRLKVVDRNLPWNGGIIGLNSFGFGGANAHVILKSNPKPKALTPKDGALKVVLASGRTFEAVEQLLESASTNADDDEYLQLINEIHSKAIPNHFFRGYGVVSSKGTHQREVIESNDDKRPIWYIYSGMGSQWASMAKDLMKIEAFAKTIQRCADVLKPEGVDLIDVLTRSTDKSFENILNSFISIAAMQVALTDLLSSLGIHPDGIVGHSVGELGCAYADGCFTPEQTVLAAYWRGKSILDTQLAKGKMAAVGLSWEDAHSRVPSDCFPVCHNSEDNCTISGPEASIEALVAKLNAEGVFAKAVNSSGYAFHSKYIAEAGPKLRKSLEKIIPNAKNRTARWISTSIPESAWNTPVAKQSSAAYHVNNLLSPVLFHEALQHVPKNAISVEIAPHGLLQAILKRALGPDATNLSLVKRGHENNVEFFLTNVGKLFAAGAQPQVLTLVRPISYPVGRGTPMLNSKVGWDHTQKWLVAKFGKETSSGETIVEVDLSKEDDAFLAGHTIDGRILFPATGYMTLAWQTFAKMQGSEFHKTPVVMENLVFHRATILNKNAVVKFGINFFDGTGAFEICESGSLAVSGKITIPESIDNEELPLEEQTPSAVAKELGTNDVYKELRLRGYDYGGIFRGIVRSDTVASTGKLQWVDNWISFMDTMLQFSILSKNLRELYLPTRIERAVINPAKHFELLSALTKEEQVETGLPVQWYSDINVIKSAGVELRGLKANLAQRRPGTQAPPTLERYQFVPNINTTDLNENSEKARLHALDVAIQVIIENSSGAVKLKGVELANGRNPDVLVANRLLQIIEGEPVLTGDVAVVTSNNNEETITAALGDSGVRVVSKDVLKEPVEQNCHFVFGIDVLSRPDTKTLENSIASIRENGFLILEETLPTYTKTGRALLTKFGFVAVQEQSLGATRVLVLARKAVDLKTRKSVVVVATEQNFNWVDDLKAALATAATEEQYVYVVCQGEELFGAVGLMTCIKNENGGKLARLVFVQDAKAEKFSLTSTLYRQQLEKDLISNVLKNGAWGTFRHLKLETQQATLQVEHAYVNALVKGDLASLKWIEAAQADTAATVDKNLETCTVYYAPINFRDVMLTSGKLAADALPGDLAEQDCVLGLEFAGRDTQGRRVMAMVPAKSLATTCVASKRMMWQIPEKWTMEEASTVPCVYSTVYYALVVRGQMKKGEKILIHAGSGGVGQAAISVALAHGLTVFTTVGSKEKREFLLKRFPKLQERNIGNSRDTSFEQLVLRETKGRGVDLVLNSLSEEKLQASIRCLGLNGRFLEIGKFDLSNNSPLGMSVFLKNTSFHGILLDSVMEGEEEMQNQVVSLVAEGIKTGAVVPLPTSVFNDQQVEQAFRFMASGKHIGKVVIKVRDEEAGKKALQPKPRLINAIPRTYMHPEKSYILVGGLGGFGLELTNWLVTRGARYIVLTSRSGVKTGYQGLMIRRWQERGVKVVIDTSDVTTAAGAKKLLENSNKLALVGGIFNLAAVLRDALIEDQTAKDFKTVADPKVTATKYLDQFSRDICTELDYFICFSSVSCGRGNIGQTNYGLANSAMERICEQRQVSGFPGTAIQWGAIGDTGLVLENLGDNDTVIGGTLPQRMPSCLQTIDLFLQQPHPVVASMVVAEKRKSDQSAGVSLIATIANILGLRDTKNIQDGASLADLGMDSLMSAEIKQTLERNFDIVLSAQEIRQLTFGALKAMDGGADVKPAAAAPAAAAGVPEANITSGGSSRTASPMGDGTQVVFTTSLIPTEAIVQLDTKAPANSKQSPIFFISPIEGFASALEPLAKRLEVPAYGLQYTEAVPSDSLESAAKFFIKQLRTVQPKGPYKLAGYSFGCLLTYVMAGILEETNEVANVIMLDGAPSYVNWYTSSFKQRYTDGTNADNDNQSYGLAYFGIVLANIDYKALVRLLIVIPTWEEKLERFAELMSNEITQPVETIKKSATLFYKKLELADGYQPTLKLKTNVTLVKPTDNSAKLDEDYRLKEVCTKPVEVHTVEGNHRTFLIEDQSLKTIQSILKRLFN
The following text describes a protein:
Function:
Specifically methylates guanosine-37 in various tRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MKFSVLTLFPQLVWPYFEDSILKRALEKNLFELEVLNLRDFSANKYQKADHTLIGGGAGQILDPEMVENALHSVKNPKHTIFLSAVGKPFKQTDAMRLAQKKHVVLVCGRYEGFDERSIELGADEVFCIGDFILTGGELGALCLIDSIARHIQGVLGNAQSLENESFENHYLEAPNFANAVFKSKEINKIPAPLEYSKGNHAKIKQLKLDLSKLRTKFYRLDLFKQHKS
The following text describes a protein:
Function:
Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.
Sequence:
MFRSKQRHTNTENCFSALSYEDIIKAFNNPSNINRNEAMAAKIRREIDLRLGGVFSHFQTLKMKKYIEEKREEVLSYGPCQLPTLGFVVHSFLKAQKYNNYPEKCWKIDVHIKKGDKSLQIKWNRKHLFCKVSCFGQFASMFDFPSAIVTDIQITESEVTKPQPLTTATHLINCCKYLKLKASRAMAITENLYNNGFISYPRTETDSFPDNFNFVDILTNLTIDREVGGMAYEVLNSLQKPLKGNCTDNAHTPIYPIVCPSEFNSKEEKDVFYLICRHFFAVLSSNCLVTTKTTEFDVGGELFHYKSKTIKQIGFMKYFDYFKIKEKSDIDFSMNENIEVESIKMVNTSYKKPELLSEYELIDKMNKKKIGTDATFHQHISKLVERKYIKIDGNGKILPTAVGAALVAAYEKLRIGFARPQLMADLEQSLREISEGKRKSDDVLKDFIRRYMEIFEKIYINADSLCIEFSKAIKKFSEDIELNSQEKTPENTQETIEMDDEVSLTTDTRADDINVDRKSCIIS
The following text describes a protein:
Function:
Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.
Subcellular Localization:
Nucleus.
Sequence:
MDYEVNANQIPVLGIEQGLIPDNLDGSVKADTATSTAMNMNDKSEISNDGSHSIHTSNPNNNGENGKNGGKPASNDFVRKLFNILESNQYSNIVRWSNTGDSFVVLDTGKFTTQILPNHFKHSNFASFVRQLNKYDFHKIKRTNEERQKSIYGEQSWEFENPNFKINDEKSLDLIKRKTPAQRKVMLEDASAPSQKTPELLSVQSENKLKSALLSNTVKKDIFNNLRKRVDKMQKDMDTVMMDNYNLKSDYQKLATKYNTLLDSLITFRTVNENLINNFNALCNVLSSKGVELPSSVYENMNINIPVPSGQSPVNISPSPSLGIPIKNSTMSPSLPSMKSLQNTPSLTGKLSTNQRLDLPPNSQGILSDTNVGQTESPEIQMPISSNSSSTTKEVDQNIVLRKGFHVLLVEDDSVSIQLCSKFLRKYGCTVQVVTDGLSAISNLEKFRYDLVLMDIVMPNLDGATATSIVRSFDNQTPIIAMTGNIEDQDLITYLQHGMNDILAKPFTRNDLHSILIRHLKDRIPLCDQNRGSGITSESPNLPPTQHIISSQQNNEQNSSLPQSLPPIHPPNHQSPLFNNRASNITPLAPLNSAMSPQSPSHLERPLTNRSPLGMTPLNDGQPAFKKQHT
The following text describes a protein:
Function:
Flavoenzyme involved in polyamine back-conversion. Catalyzes the oxidation of the secondary amino group of polyamines, such as spermine, spermidine and their acetyl derivatives. Plays an important role in the regulation of polyamine intracellular concentration (Probable).
Subcellular Localization:
Secreted, extracellular space, apoplast. Secreted, cell wall.
Sequence:
MSSSPSFGLLAVAALLLALSLAQHGSLAATVGPRVIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGINVELGANWVEGVNGGKMNPIWPIVNSTLKLRNFRSDFDYLAQNVYKEDGGVYDEDYVQKRIELADSVEEMGEKLSATLHASGRDDMSILAMQRLNEHQPNGPATPVDMVVDYYKFDYEFAEPPRVTSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYLAGQYLKTDDKSGKIVDPRLQLNKVVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDLIQFKPKLPTWKVRAIYQFDMAVYTKIFLKFPRKFWPEGKGREFFLYASSRRGYYGVWQEFEKQYPDANVLLVTVTDEESRRIEQQSDEQTKAEIMQVLRKMFPGKDVPDATDILVPRWWSDRFYKGTFSNWPVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEILINCAQKKMCKYHVQGKYD
The following text describes a protein:
Function:
Function in exit from the mitotic cycle. Contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. Interacts with protein kinase A.
Sequence:
MLVSSNEEQLTAHTPTSSSSIEPKILAACSYSLSVGPCSLAVSPKGVNSKSPSLKNETAFVVDSVSTLSAESSALLYNTQSSLLTGLSMNGYLGEYQEDIIHHLITREKNFLLNVHLSNQQPELRWSMRPALVNFIVEIHNGFDLSIDTLPLSISLMDSYVSRRVVYCKHIQLVACVCLWIASKFHETEDRVPLLQELKLACKNIYAEDLFIRMERHILDTLDWDISIPTPASYIPVLDPIFFLVLDASMFVPNLFKFPASKIACSVMNIVNEHVGSFLLTHPSMESYRKDDNFLWPEDLDTVTSYMENMSKRYANEECTDLLFSSLGRISSILAKKYPEQCAMAAWCNMTEKDTERTL
The following text describes a protein:
Function:
Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein (By similarity).
Sequence:
MDFLRLRLPGLHQALRGALDSFSAFVSYLVGDTVPTVERQTQAAEELGEVTEGKVVGEEAQEVLEGLRSGQSEGVEAPEETRRCQEGSLAGEQTWGWRADSSARPQAERQDTGSWKAAEDARGQEPSVPLKPEAEPGTHRDRSSNTAQEIWEHGEEEASSGEPLRTCEQKEEEEEVVRAAESGMAEGVESQPTWHSEPGGNAGTEGQHVTEDSKEIDWVAKDMVAEIEWFGAKGIDKEEERMVPMRDGERARAQGTQCPGAESEDQAMLSREAWTVSDREGADSLGVQGTEYGSDPGDNFPGTTGRVWVLEEADKGDQQDEVDEKREAEVRFPIQTLEAERTGEMTEGHIAEEEAMGEQETEGSFEDEERQDLAIRDNGVSLEEEVRAEESSREKRNSWATEPTLVLDTEAKDEPDWEDSPEVSTEELFVGERSEAAQMTPEVLRVKVTEGQDPELVRHSQALTKQLEEGQKGQEETSGAPDLSPERVLSLKEYPGPVGFAGPELEAWGNWSRGVDRRNSQEVKADAEAGKEQTATEQAVEIRAEGGQEAQQPEVFGSGGEEALTSVALNPELEGSQGAEAGTEESVEESKPTENEAAEEEAVVPWEADGTCRKRRLEEVTLSLQDSEDTETSYLAEEIIVGIRAVDTEEGPKWEAGLAPETELGKAWCSEGRGEAGRGTELEETTEKQSGQEVGLVGSAEKVSGYDIQEIDGTEEGEQAEMETSVMAEDIRGTDGVTLGSQAERAEGSITPMETEGLLRDQMLLEEEAGGGQSREQKVHNSEGEIQTLDDSSDQEGQQTHQIPTVAVPGPLESAEATAGAPGDVHSNWNEALLPGSRLDVSVPRSRVLLSRSSSRRRSRPSFHRISVPEPQCDPPSPQPQAERPVPEQSSLQLEETPELSATKPEGTPVPARRKMLGRGFGFAHPGMMQELQARLSQPKPQ
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MEGYVAGGSSSAGTSAGHTSTTGSIPTSANTSTSTESIIQRLINCGVPAEYAERGQAGLADYAKNHRFQLPRVISGLLPGMEELEAVSTTDADEAQGPGTRKGFLSQCRDAIEWVKWVMFQGEPQAILEVAGQGGGGARGVCGAVWGVNDIAYRCRTCEHDPTCAICVSCFQLGNHSTHDYYIMRTGGGCCDCGDITAWKQAGFCSRHSGFGQAVSLPSSIEEAATPVLEALLIHWVRWLKAADAVTEGKSKIWKNLKVEEKVASQLSVVCVELLMELCSYGETMLAFIADLMGKNASGILDTLMNTEHFLPKPVSASLHELLYKLLGDSNFKLSFAKVFISHYPKFFKDSAAAESAAIGITSTSKYSEQAILNSFSVQIFTVPTLTPKLVIESRLLEMLLGTLKEFFLACAGEDGRLLGSKGLLVKRLYHRILEDIRYVMNHFEVAKYVAERKPELLRAWLHLLAFVQGMYPQRRMTGIHVEEDNEVWSSGYFLESQMASIHSLFVAGAAAASNASFEETYLSKPCGSFGFVKEALGNGESFSRPVRIGCVLREPNETAGASGSGPSEAVVEMRDATVTVDAVEGIQSEIVPHPVEKKDVGFVSPARMTMPASLVWLISECTQVLDTWLRLDAAREVAKSGQSGCEGGQESEQRSATQVQHGKGRFLSVPQNQGDVDVDIGEAEPVAKAGVTEWWMGSEPVHLAPTANCEVDEWAVVDFDVSRQEVSFHIPLHRMLGLLLHKALDYFALYTEASAGPAFVSPNVHASGERFLAQMFPPGFTSVLLEHPLRLQVLCAQVQAGMWRYNGISSNDLSILYHTVHWCEDSLELDLFLLQCCAVMAPPEEFVERLQVRFLLSDYFTLVLSCPNEYEVTLAQELLVLMIRLVSERGFCGITEVDAIRRDLVWRLAVGDATHSVLLKALSPRLRGSKHVQEILNSVATYRNPSGMQQGKYVLREDYWCELDLYHLRWNSRNIQVAEDRYLRARKVPAMFVQLPRWKQPYKQFQNLGQFSICRRVHDMLRSVFFHAAFAENPSKSRAPEGLLLSALHLLALALDVCSAYKMSAEGATPGASSTISRPLGLDMCSTDKNCEDTPPLLLDSVKRVAVAREDGSMMEEQQSMLSTLVLVLRKNNTGDNMATSALGNFRVGGLIKNLLLRFGELNQNCLGEIELLAPEIFQRTPATGATHWADGSGDNKSKDVSSVSEFDITRAVVRKRQAAVMAKMKAAQERFAVVNQCAEEGNSQGREEEADAKRARKSEGGSDDVCKETQLHCALCLDSASASPLCFLTFIQKSNLLEITERTTPSWDHRTVVLPLQAEREGVAPGGPSTMCTPVGDGTHPNLQSTVELLRWMQETLVDAPTRTRLLEGENFFELLRNGLPLGLRNAVPSTPAVTSEATVAPSGDTESEEVESSCEITDLEISSEVGTSDTSDALLMNWWEDNHERTEKEGSSSNRDIAAETVLAEYVAVVSRPQALVCRGLQSSVQAPAEQGWEGNLTSARRATESMLHSRIGMNDPVGIYLSACGHAVHQDCHNRYFSSLVQRYNSRAPFEGERIVDLDLGEFLCPVCRRLANSVFPVLPGHTGLNSPFKTPNAPQISVRITPDSPTTLQLEHAFRMLIKAEELVSKSGFRKVVDPQLPDMLRGVLDDLAKRLWFFYPGNDQFYFLEHGRVHEGLLLWDVFRYTLMSAELAARSNELIVSNSSGLVTLVNVGDATHGSVLPLLLHAAKATQSQSRQAILLRARGLQLLMDSLANGISRVLSAEKALHGNVSSLLQNLDNGHNAADLQFWKRMADPILVHDSFSSFMWLLFCLPLPFPANGAPFTALVHLFYLVSITQIIAQAGTSLALDTELAPTTVSFVASIHASLIGTRLQSSSVDENIAIPAGPALVAIRRLTLPFLRRCYLLKTLITGSAQIVPIARAHQWELPQGHEVPTGSSMFSNDARDANSQILGDGEELDQLESIFCIPPLAKILEENAVQKLVLTWCRHVRTDTGMRYFPDVPRLTTAAPFRMMQLPRLFQDLLQRFVKERCRRCNSVPDKPALCLLCGALYCAACPKSICRQGELYRHAMVCGAGIGVFLMLRTTNIRLQRCKRQAMWPSPYLDDFGEEDIDLRRGKPLFLSQERYHALSAMVAAHGLDYSSPVLSHTTRESAV
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MATLLDIEGTVCSISFVHDILFPYALEKLPQLLKNEQFPIKPGGNQTSDLTPYLESFPEEYKQSAQALEDHVIDLTEKNVKAPYLKALQGYIWKSGYQSGEIKAPLYPDAVDYMKRVVDGGNKVFIYSSGSVPAQKLLFGYSSAGDLTPLISDYFDTVNAGPKMEAASYTTILKAIGFEADRVLFLSDNVREIEAAKKAGLRAYVAERPGNAKLTPQEKEDNVIKTSFEGIEI
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase activity (By similarity). During embryonic and larval development, regulates the pattern of axonal projections of class IV nociceptive sensory neurons (C4da) downstream of netrin receptor fra. Regulates fine-scale topography of C4da axon terminals upon neuronal activity. During eye development, consolidates the attachment of R8 photoreceptor growth cones to the target medulla layer, probably downstream of fra.
Subcellular Localization:
Cell projection, axon. Perikaryon. Note=Colocalizes with fra and pico.
Domain:
The fibronectin type-III, SPRY and coil-coil domains are necessary for C4da axon patterning.
Sequence:
MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGNGGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCSNTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRFCAREALRCQMCETDPKVASLICEQCEIRYCDACRELTHPARGPLAKHTLVKPRGAAQQRESVCGEHEETLSQYCLSCKAPACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQQLSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWHQEVTNAAPRVSPIVDLTLDDAALARAIDNLNFIQMRAVKDGDERCPAAPMTPTILPSDCSAENNSVTVAWQPPNHSFVEGYVLELDDGSGGEFREVYCGKETICTVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQTAEVAWFTFDPVLSGGAGSGLIFSKNNATVSVEGWEHRVALGSVGFSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKMLGKDEKSFAMYIDRQRSWFQHNSIHERRVEGGITTGSTIGVLLDLERHTLSFLVNEMPQGSVAFRDLYGVFYPAVSINRGVTLTMHTAMDAPKMDYF
The following text describes a protein:
Function:
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
Sequence:
MKVQPVLVNKDNYSYLVIDEKNKVAIAIDPCEPNKVISSLSSISSDIKINSVFTTHHHWDHAGGNNLIKTIIKDINVYGRDERFEGITKKLENNEVLKIGSLKIKTLDAPAHTSSHVLYLIEDENEPNQVKSLFTGDTLFIGGCGRLFEGNPEQMYNALYNVIGKLPDNTLVYVGHEYTLKNLEFAKTLESENENKELYNFYDQCKEKLANGEFTVPSSIAQEKLINPFMRCHLPSIYNHYLKENPNSINPPSPIDVLGFIRSLKDKF
The following text describes a protein:
Function:
Demethylates proteins that have been reversibly carboxymethylated.
Sequence:
MFRGMYKSTLPPVDPNSLSAHPNLADQLSDKDYYSVEWNQYFDKCRDIKLPNTENTFRIYECNDHVDDGNLFVFLHGGGYTSLSWSLVVDKIRKQFDNVRLMCYDCRGHGETKTSNDLDLSIGTLVDDCSSLINHYQEEIALKSNDPEKNLKVIIVGHSMGGAVAIKTSSSEKVKNLMGLVVIDVVEGTALQALSSMRSILAKRPKHFESVKDAIKWSISTGTIKNIESARVSVPSQIKLSKEDNKYHWIAQLEKTDIYWNDWFLGLSKEFLSNKVIKLLILAGTDRLDRELTIAQMQGKFQLILLPLCGHVIQEDNLPGINIRV
The following text describes a protein:
Function:
Probable transcription factor that may function in the maintenance of the proper function of the central cell in pollen tube attraction.
Subcellular Localization:
Nucleus.
Sequence:
MDSSMSTKKKTKLSVRNQTCFKKSSLSSSSTAKKTTNLSMREQTMFKKALELSTLCNIDVCVIYYGRDGKLIKTWPEDQSKVRDMAERFSRLHERERCKKRTNLSLFLRKKILDDTKLSEKVLEMEDSLESGLRVLQDKLLLLQPEKNQTEFGQTRAVSSTTNPLSPPPSLIEDHRHQQWTEPLMSGVSNTEQDLSTSSLSQNQSRISVFLYNHDNRSFYQVPDSVSSFDQSALLGEQGSGLGSNFDLPPMVFPPQMQTQTPLVPFDQFAAWNQAPSFADPMMFPYN
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of toxin RelE2; Induces its own promoter, in combination with RelG represses its own promoter. Has been seen to bind DNA in complex with toxin RelG but not alone.
Sequence:
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGEDEIRAEFGVPRRPH
The following text describes a protein:
Function:
Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glr-1 subunit of AMPA-type glutamate receptors (AMPRs) in the ventral nerve cord. This may be partly through interacting with the small GTPase rab-6.2 in its active GTP-bound state.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cytoplasm. Synapse. Perikaryon. Note=In trans cisternae of Golgi or trans-Golgi network. Localizes to Golgi-associated structures. Partially co-localizes with glr-1 at the synapse. Localizes in endosome-like structures in ventral cord dendrites. During hypoxia, diffused cytoplasmic localization. Localization in the ventral nerve cord is regulated by egl-9 isoform e and cdk-5. Co-localizes with rab-6.2 in neuronal cell bodies. Co-localizes with rme-8 in puntate structures in neuronal cell bodies and in the intestine.
Domain:
PDZ protein interaction domains may not be essential for function in vulval induction.
Sequence:
MSSEAVAQATAATTSPEHGVPTSSATPTPPPSKGGGAGGGGGGEQQQVPFQMIPPGHFFANPFLNPYIPTAGAPAQEGEAQPQMVFSPAQYQEVMHHYFQQMMAASGAQFPIPFPMQFQPALQQPRPSSQASSSHRSEDDNGRQTAGSVVSSNVSPNHREVRPAEDSTETSGVVQNNDELLVPTSTSSDVTIGDVIEKSDSPENSQESAGGEEKSEEKRKLSGDRTDSLIRKQMSEMEKEITRRSQNKNIKTIDDDGLAELIGGSSTRTVADDFSPFVDKSGLSYTAPAPPSTEKSAPKESLNQLRSSFNLPDDSTTVGPVGPSTVPQQSQQFANNSMFMANAGNFVQNAFPIGVTMTPQATFGAAPGFQMMQPHQHNLFMQQPNPTFVNNGTNPFLQTQATLPNFVQNGTAPLVPTVSAQQFTPEQLAAAFAQQQIAQSAAPTPFDSPPPSMPSTSSGPSGALAPPPPPSHPIPRRVSGNGWPEENKENGTSTSTTNGAQSVPAAAGTDDPVWVLRDSYLKKMQREQRTSEEEEMSWQEAATAAQEAAENGGGDDQEEQETDRLLNGGTTGASTKGAERRGSVDKKKNSKETMVHEPAVLIEGVLFRARYLGSTQMLCESRGSKAARMAQAQEAVARVKAPEGDVQPSTEIDLFISTEKIMVLNTDLQRISDTDVRQDILMDHALRTISYIADIGDLVVLMARRMSTSHSDESCSDGDSSGGGVRKTPKVICHVFESDEASFIAQSIGQAFQVAYVEFLRANGIDDPSYLRQIDYQEVLNSQELLGDELEMFAKKETQKEVVVPKKAGEPLGIVVVESGWGSMLPTVVLAHMNPVGPAAHSNKLNIGDQIININGISLVGLPLSAAQTQIKNMKTATAVRMTVVSTPPVVEVRIRRPDTKYQLGFSVQNGVICSLLRGGIAERGGIRVGHRIIEINGTSVVAVAHDRIVNMLATAVGEIHMKTMPTSMFRLLTGQEQPQYI
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Also catalyzes the hydroxylation of 60S ribosomal protein L8 (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAQNIPTKRQSAFGVFVKSKVKGPTIQQTGATKTPKTPSKIRRLSIRKSTRKIKHALKGKSGSQPVAAHKDMPVTQNTGQGEEGVKLKGYKMKTSPARVQEPQRTGSPEENSIGKGNIKTNIKGSQNVQAGQKFQERIATQHPQKRKPFGIEDSDDKTPVKRVRSDTAKSVQSPAKAVDVGEVEDSTEEAEKMFEWLIHPVKKEKFFSELWEKKPLLVKRHLESYNDGWFSTEDLTKILHENDIQFGRNLDVTTYEGGQRETHNPPGRANPAVVWDYYQNGCSVRLLNPQTYSQGVWRLCSTLQEYFSSMVGANIYLTPPGTQGFAPHYDDIEAFVLQLEGNFSQEEIGEAILDVTLEPGDLLYFPRGTIHQASALPDTHSLHITVSTCQRNTWGDLMEKLVPAALTMAFSEDVEFRQALPRDYLDYMGLANADLDDPRRKAFLETLQSLLSRLVNYVPVDAGVDQKAVEFMRDCLPPVFTKNERACSIYGCRTRLEKGRVVGSVDLKTSTPVKLIRKGAARLVMEGEQVFLYHVLENARVYHGAELQPIEVPPEAAPAIEYLMHSYPEYVTVDSFPLDHQQDKIDLAMLMFEKGIIIAQEPASVDN
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MEVSGEFTASLTSSSSTDEVFNVYFKGLVCGETVSIRICDTSYRCLYELRISSLFDAGDLVELQALMEALNVAVNLGLKRVAIFCRSNLVYQYLKGKRQPTSNKVTTLVDQVNLIRSKFVYQALFHMKRNYMKFVYRLIAKWTNSDSYFTIIEQCTICFEYIHNDQIYTVHKCLHRYCFSCMRQHVEAKLLQGKLPECPHEKCESKIGIDSCKKFLNPELYDIMRLRVKEASILPKDRVYCPFSKCSAFMSKTEVIAHTPSSSSTAAGDTGMRRCVECNRLFCINCKVPWHDDMTCSGYMKSYVFQSSNDAKLKSLATKERWRECINCKNLVELTSGCYHIECRCGYQFCYTCGAEWLDKKQTCGCRLWDEHNIIYA