lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity).
Subcellular Localization:
Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes mainly at the nuclear periphery and the endoplasmic reticulum membrane.
Sequence:
MILRFRSKRGMARAEFQPTDTLAMLSAKILSDILKNDYSPENVSLCQNESDQGVIFSNLNDQTLQDAGLTHGQMLYLRLGTPNSDIASSNNEPALTVTGAPKQVSTPDVSEKKPSMPVIQDPIDDSLEKEDGLIRRSMTSLCRHGPKGMCDYCSPLEPYDESYRQENKIKHLSFHAYLRKINSNVNKYASSQSFIPPLEEPSFTVKEKCPSGHPPWPAGICTKCQPSTVMLNLQPFRVIDHIEFASPGIVDSFLNKWRQSGFQRIGYTYGHFEQYNNVPLGIKGVIEAIYEPPQVSEADGVTLEEWADEALVEQVATACGLRRIGIIFTDLTDDGSNSGKVLCKRHSDSYFLSSLEVYNSANFQTKFKNPCKWSRSGYFGSKFVTSVISGNLNGEIEVMSYQVSNIGTALYQADLIQPSVDPDRMLVKKEDQTRYVPDVLYRYTDKYGKQVSENAKPAFPVSFLLVTLTDGFPEKPDPLFSNNDTSIITTLESTDETGRLRQLAKLFDHNAIANGSLSNFSVLLAIAKLSILGKDDLAALASYATAPTEENEKNLNSRESYQTLLAILYSSL
The following text describes a protein:
Function:
Catalyzes the production of firefly sulfoluciferin from luciferin using the sulfo-donor 3'-phosphoadenylyl sulfate (PAPS). Is also able to catalyze the reverse reaction, i.e. the adenosine 3',5'-bisphosphate-dependent desulfonation of sulfoluciferin. Can use either D- or L-luciferin stereoisomer as substrate. Sulfoluciferin, which is not a substrate of P.pyralis luciferase, likely serves as a luciferin storage form in fireflies.
Miscellaneous:
MISCELLANEOUS: Both D- and L-luciferin stereoisomers are found within the firefly. L-luciferin is the likely biosynthetic precursor to D-luciferin, though D-luciferin is the major stereoisomer by static abundance.
Sequence:
MFASILGKIPQYSTISSKCSLKECRKVKKVENSDEIGEIIHRDFLDPFCNEYVLIGEEETSLGINYLQFEEEIRTFEIRDSDIIVASYPKAGTTWTQELVWLIGNDLDFKAAEEHLDKRFPHFELCTIVNFAKMTEMLGSTRPEYIGNSINYLRDLEGTRFIKTHLTYNLLPEQILNGNRKPKIIYVMRDPKDVCVSYYHHGRLIQGWRADFQNFSKVFLSEKIMFGSYWKHVLGYWEHRDKPNVLILTYEEMKKDLLSVIRKTAQFLDKKLNENKIPQLLKHLSFESMKNNRAVNQQDKIESRMKHKLVPEQGAFMRSGTSQNYKGEMSEELILKFDEWTKKSISGSSFVTEPIADLYLNTSQKSVPKM
The following text describes a protein:
Function:
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
Miscellaneous:
MISCELLANEOUS: In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
Sequence:
MMTLLAQAARDRLLRPLDVQFSRMIAGDDDPRLQLAAAILSAEVGAGHVCLPLRYLQPELLFGGRQPDLSLALWQAAGSPDKAQWLQALQNAPVVSDGSQPTPLVLQQERLYLQRMWQYEGDVVQFIASDSVFINRDSDFMTSKGIATSVDESLLRETLDALFGCAGSEVDWQKVAAAVAATRRISVISGGPGTGKTTTVAKLLTALIRLSQGQRLRIKLAAPTGKAAARLTESLGKAIRQFFLTDDERKLFPDQASTLHRLLGVQPNSQRLRYHRGNPLNLDVLVVDEASMVDLPMMARLIAALPAKAKVIFLGDRDQLASVEAGAVLGDICRFAELGYSEQRAQQLTQLTGYLLTNNALTSNVLTNKALANKAQPDETYSDSANVRDSLCLLRKSYRFDEKSGIGQLALAVNAGEYRQALSVLNSAYSDVERFPLADEEDYQVLLEACAVGYQHYLERVAALAPAAEVLAAFGRYQLLCALRSGPFGVSGLNERIEQVLHRKGFIIRPSGPSGRWYVGRPVMIELNDSALGLFNGDIGIALHDNEGELRVYFQLPDGNIKSVQPSRLPSHETAYAMTVHKSQGSEFEHTALVLPNTFMPVLTRELVYTAITRARQHLTLYCSDAVLSHAIRTPTLRLSGLVDRLNTLNRQ
The following text describes a protein:
Function:
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MVGANASSISTQYYKLAHLGSISYTIYTSSDNNDQALLELELTIRHKWPQILVTYYNKSLYYFVFGHNKVDSETIDLTKEFPQLSTKYTDTVNVDQFPNPHKSTKNDDNLAWASLSFLKATKKMILYNLSLSGAIKLFGNYCVAPTGDSVYSILCIDPILFQNGDLVVSCVEKPFTQLFSSSVAYPRNLAIDTNFVIYLIPSGIRCHLFDPTSLRNNLIEKPQIENGKLLELLKITTGVQCDESTLWVKLIPNLKHLNNQTSAIGKFIHSVENKKFILWPWDLCLLQFGKFEPAIEEEGLLESSELNNPLHLISDFLDFRIAHNTQLQQQRDSLSDQQQGETVNVPLSAGSVHATGANSFGNVPDISKDVDTVGLSTTTPIETDLFNLQNTEEFFKNDSIHMNLEDQIHKKETEPENESENDMEIDDLFGGDESDDNDDLEEAGNEEEKPTPSNNTIDKNGVIGNALEEAFIADATPSKENINLDSKIMPPDSTSEEAVPDKENFKPKETKPSYIDILKDKMTIEKIVNSPDYKDPGAPLPVVPTPLVSSTVSQSAVTTNPPSVGSAPGPAPGPAPGTETLYEANNAYAQSSQISQLPQQKSAFSPILFNPIIKSDIDTKYGKGGKFYVAKDSSTNGNLDMKNRSLRATSVSGMEIPFSSEDKKRLQQNLEVLDSSTTSDNEGGEDIEDDDNDYEDEGDDDEEEEGEEEEEEESDEDEISDIGKSTPLKLNTQNESVPPQQSNYNPVNITDSGSNTTNNITDKQGYENTEGFGTPFPNQISKYSIKPESPFASNELQSSVSPMYFDTSQSHQSPQLQPSTGTLEVLKASSLESPSKISESSNYLPLILRSINVSTIPSSYLMNNLISSKLLPSFTISDDDLENDLDITKSNEMIVKLGFLKEFLDFMSPNIIFDLGLMKNDESDYYINGVNDLLLNSDPGISSDWILNSLSKVFPCTYPMKLIELLYDFKSLELEDQLDSQLNFLNEIADEEDFVGPKALYRKLKALEWDSFSLNESNKTSFEKYKNVMEKLSAENTVSDDDYFKLPMVKTRILKNGNIVNLNNIGLKFWKYLNFSPVKKQKDFQILLIAETHRNTASYATEFLDQIIQNYKECNFGTISKVNLSTVETRSDLEPISDGLVLVHKEHDQSYNDFYIQTNKKLISLVELIKLDLINKTNNFEFGKPLLLFFIDFNDSSNSNVQVCKIFRNFKVALTTHQLPLVDIFTKIVPSSLLVKKVHHETALKVFSNYKLTKISMNLYNECPNDLANKSIVKNLFTTIVKDPPSKIQFKFMNSSYRDNSSNDDIFLHLAYERSIDNSWFVASWSDPLGRVVHVKSWYCSDSVSKSEKSTYRGDIMDIMSITDDIWSISTDLFKVLNDELGSFGGKKFLVLTRINSIIPDVELVHWKRLSSKHKEISLIVVSVRQTPRIVGSNESEDLGPKSNDYAPTPMIQDKDIFFGFKQTFSTSNTSSPSASGGALVTSPNSLSLHSPQQFLNAPANFLSPQDLIAPTSSGISGAKPGSSGIDPEVVLENQDNEVYGVIPKVPLPSFNSPTRFCMKTGYLMMQVNQPSEEEYKDDIKKTYLVYEINLLSCSNYWNLDVLMKLIMSQYKQMIALNDILCMNPIVGESDILGTHSRNNAIVPWHINAVGKLLDYLVHIYVDKD
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MRICIFGAGAVGSHIAVRLARAGHEVSCVMRGAHLEAARAGGLKLRVGDSEVTAKVNASGDPAQLGPQDVVISTLKATALTGLVSSIKPLLQDDTAIVFAQNGIPWWYGIGLPPRHPTPPDISFLDPGGRLRACIPKERIIGGVIFSSNEVVSPGVVQNLTPDRNRLLIGECDDRNCERITKLRGVLNDARLESPPVAEIREAIWSKLLTNMSLSVLCLLTGQTARGVRDDPAFAEVIPRMLNEANDIAQHFIPEVKRVTRSGPAPNHKPSLLQDYEIGRAMEIDVLVKAPAAFARTSGLPTPTLDLIAALAIQKARDKGLYSA
The following text describes a protein:
Function:
Cysteine protease which plays an essential role in merozoite egress from host erythrocytes. May cleave host SPTB/beta spectrin and ANK1/ankyrin-1 which disrupts host erythrocyte actin cytoskeleton and leads to host erythrocyte cell membrane rupture.
Subcellular Localization:
Parasitophorous vacuole lumen. Parasitophorous vacuole membrane; Peripheral membrane protein.
Sequence:
MICPIFFLYIINVLFTQYFIKCEGNKVTVISHNNGHNDNLDVNKNGVISQENVFDTSESLNLPSNKKVGSDDLNTTTISFTVPDNLENEVKVVSSSESGKGATVSHTKVTSEGLSDTQPNVTQSVSSSTHTPGSLDSTMSTEQHSSVSQSSLPTESSSETLNKATVPEIPIQINSGLLKNYNGVKVTGSCGSYFRVYLVPHILIYALTKYSVIQLESLFNDNARIDVEHKGELQNKCSEGYHFKLVVYITHNVLNLKWKTYKPNEESKSEDSDVRKYRIPKLERPFTSIQVYTANSKAGVIETKNYNIRTDIPDTCDAIATDCFLNGNVNIEKCFQCTLLVQKKDKSHECFKYVSSEMKKKMNEIKVKAQDDFNPNEYKLIESIDNILSKIYKKANKPFEISKDLINLEDLDYQFKNELLEYCKLLKKVDTSGTLEEYELGNAEDIYNNLTRLLKSHSDENIVTLQGKLRNTAICIKNVDEWILNKRGLTLPSESPSESSSKSDSYLNTFNDKDKNEDKDDMSKNSKEEFKNDDKENSDDQNNNDSNKKDDENNINNGDTNYVYDFDDDDYDNNSYEKDMYESPIKENKNGVIDLEKYGNQIKLKSPYFKNSKYCNYEYCNRWRDKTSCISQIEVEEQGNCGLCWIFASKLHFETIRCMRGYGHFRSSALYVANCSKRKPIDRCEEGSNPLEFLRILDEKKFLPLESNYPYSYTSAGNSCPKLPNSWTNLWGDTKLLFNKKVHRYIGNKGFISHETSYFKNNMDLFIDMVKREVQNKGSVIIYIKTQDVIGYDFNGKGVHSMCGDRTPDHAANIIGYGNYINKKGEKRSYWLIRNSWSYYWGDEGNFRVDMLGPKNCLYNFIHTVVFFKLDLGTIHVPKKKSWKKNVYFLRHNPDFMYSLYYNNYEPETSQDFESENDYDNAFVHGQSNESDETNKEGKNVHNSVEKKIQILHILKHIKDSQIKRGLVKYDNINETKDEHTCSRVNSQDAEKYEECKKFCLTKWNECKDHYSPGYCLTDLYKGEDCNFCYV
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MSLNSTGKADEDERREDVAVAAVERQDSREVDEGKGTWKHAAFHVATTIATPAAYAPLPFALASLGWPLGVSSLVGATLATWYSSLLIASLWRWNGKKQITYRHLAESIFGFWGYWSIAFFQQVASLGNNIAIQIAAGSSLKAVYKHYHKEGTLTLQHFIIFFGAFELFLSQLPDIHSLRWVNALCTFSTIGFAGTTIGVTLYNGKNMDRKSVSYSVQGSSSLKRFKAFNALGAIAFSFGDAMLPEIQNTVKEPAKKNLYKGVSAAYTVIILTYWQLAFCGYWAFGSEVQPYILASLTVPEWTIVMANLFAVIQISGCYQIYCRPTYAYFENNMLRSKTASYFPLKNCLIRLVCTSIYIVLITLIAAAMPFFGDFVSICGAIGFTPLDFVFPAIAYLKSGRMPKNMELRISVQLLNLAIATWFSVVAVLGCIGAVRFIVEDIKTYKFFHDL
The following text describes a protein:
Function:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Sequence:
MKSTGVQRVTASDHPMPQQGVRSHSWRGSASINDRIAMDKYQERRPLSLRKTRSQRLLDQPALHSVAKTAKLMPRFTRIQVLSIIKLATMDKLRESGAGDDPTTQQRLATDGQGGTAAVAAAGGEGTSDEYHHQFYNTGRIGRRNALPDILGTHCTTTTADLSSQLGSLSTSDCAGKASDGSSSCIAAGNNGQPPPTTTAT
The following text describes a protein:
Function:
Involved in the normal targeting of ventral muscle, muscle 12, by motoneurons. May function as an axon guidance molecule involved in neuromuscular specificity.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MFHSLVLMACALAALSVAQGAGSARSKSLPLSLSLSVSVSSSLASASSPGAAADPTAAFTVTATAPTPASAPFAGKQLNRCRQSCYQQLSKDWHYCKDSVDCTNCCQKLVAPFELRILKAQRQESLVLTDIGWDEMIANASRQCLITWEVSGGGLIGNLLTDTARAELSLWPDTVYNIQVKCKHKLTGLMRRSIKLNVDTSQLVGTTTTTTTSKSSIQRQHLEQPVDHTDALEHSQHIRIPRPTDRVYIISALPTPSELGGVVYPAFGALAFFLALLVMFLFLRPQRKRFPLDADSADTATLIGRSSSSSRNSMDASTLHV
The following text describes a protein:
Function:
Required for normal embryonic development.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAVPGARGASLSGLLPAQTSLEYALLDAVTQQEKDDLVYQYLQKVDGWEQDLAVPEFPEGLEWLNTEEPLSIYRDLCGKVVILDFFTYCCINCIHVLPDLHALERTFSDTDGLLIVGVHSAKFPNEKVLDNIKSAVLRYNITHPVVNDTDASLWQELEVSCWPTLVILGPRGNLLFSLIGEGHKDKLFSYTSIALKYYKDRGQIRDGKIGIKLFKESLPPSPLLFPGKVAADPTTGRLVVADTGHHRILVLQKNGQIQYSIGGPNPGRKDGVFSESSFHSPQGVAIADNVIYVADTENHLIRKIDLEAEKVSTVAGIGVQGTDTEGGEEGDKQPISSPWDVALGTSGSKVQRNDILWIAMAGTHQIWAFLLDSGTLPKKSDLKKGTCLRFAGSGNEENRNNAYPHKAGFAQPSGLALAPEEPWSCLFVADSESSTVRTVSLRDGAVKHLVGGERDPMNLFAFGDVDGAGISAKLQHPLGVAWDEKRHLLYVADSYNHKIKVVDPNTKVCTTLAGTGDANDASSSFAESAFNEPGGLCIGERGRLLYVADTNNHQIKVMDLEARTVSVLPVFKSDSAVVDGSFPREKQKTVPKVPKSAPNISLPPVTVHPGQALQLGLRLELPPGAKLTEGAPSGWFLKAEGNEWLLQEQIPSGDIENISNQPAISLQIPTECLSLEAVVSVTVFLYYCSADSSACMMKGVVFRQPLQINSVQPACAAPVELTYAF
The following text describes a protein:
Function:
Integrase is necessary for integration of the phage into the host genome by site-specific recombination.
Sequence:
MCPQMKLNARQVETAKPKDKTYKMADGGGLYLEVSAKGSKYWRMKYRRPSDKKEDRLAFGVWPTVTLAQARAKRDEAKKLLVQGIDPKVVQKEARAENSGAYTFEAIAREWHASNKRWSEDHRSRVLRYLELYIFPHIGSSDIRQLKTSHLLAPIKKVDASGKHDVAQRLQQRVTAIMRYAVQNDYIDSNPASDMAGALSTTKARHYPALPSSRFPEFLARLAAYRGRVMTRIAVKLSLLTFVRSSELRFARWDEFDFDKSLWRIPAKREEIKGVRYSYRGMKMKEEHIVPLSRQAMILLNQLKQISGDKELLFPGDHDATKVMSENTVNSALRAMGYDTKTEVCGHGFRTMARGALGESGLWSDDAIERQLSHSERNNVRAAYIHTSEHLDERRLMMQWWADYLDMNRNKYISLMIIQNTKKYLNKNSYWLIFKMSVK
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MGVALSITAFPVLARILAELKLLTTDLGRMAMSAAAVNDVAAWILLALAVALSGSGSPIISLWVLLTAAGFVAAIFLFLRPALAWMARRSPEGEPVKELYICATLAIVLAAGFVTDTIGIHALFGAFLVGIAVPKDGPFAGVLIEKVEDLISGLFLPLYFVSSGLKTNVATIRGAKSWGLLVLVIVNACLGKIGGTVITSLLVKIPVREAVTLGFLMNTKGLVELIVLNIGKDRKVLNDEAFAIMVLMALFTTFITTPIVMAIYKPARPTAPYKRRTVDGGEADGELRVLACFHTNRNIPTLLNLVESSRGTGRGRLVMYAMHLVELSERSSAITLVQRARRNGMPFFNSGDKAEQMVVAFEAFQQLSSVRVRPMTAISDLDTIHRDVIDSATAKRAAIVVMPYHKMLQHDGTFQSLGSAYHAINKRVLREAPCSVAVLVDRGLGGHAQVSAKNVAFSVAALFFGGPDDREALAYATRMAEHPGVAVTLERFRPSRAQPDEEDAADEAAVEAFKSKVGMVKDGSVRFDERPAQSKAEVMEAINSLSMFSVFVVGRMPPTAPLVEKPDELGPVGSYLASPEFRTSASVLVVKRYDPAANPASKRYDPKARPPAATEEDALDELTGAAVVPVAHSPMNHDIV
The following text describes a protein:
Function:
Catalyzes the attachment of tryptophan to tRNA(Trp).
Subcellular Localization:
Cytoplasm.
Sequence:
MTKPIVLSGAQPSGELTIGNYMGALRQWVAMQDSHDCLYCVVDLHAITVRQDPQALREACLDTLALYLACGVDPKKSTVFIQSQVPQHTQLGWALNCYTQMGELSRMTQFKDKSQKHANNINVGLFGYPVLMAADILLYQANEIPVGQDQKQHLELTRDIATRFNNAYGETFTIPEPFIPEHGAKVMSLQDPLKKMSKSDDNRNNVIGLLEDPKAVMKKLKKAMTDSDEPPVVRFDIENKPGVSNLLSLMSGITGQSIASLEAEFEGKMYGHLKGAAGEAVVGMLEPLQERYRALRADRAYLDQVMRAGAENAQARAEVTLKKVYEKIGLLV
The following text describes a protein:
Function:
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
Sequence:
MTMASDPKMNPQSGLLSAEANHAAALAAFGGVLTVDLDAIIANWRKLEKTAVPAECAAVIKADAYGCGAAQVARALHKAGCKTFFVATIEEARKVRAAVPEPTIYVLGGYFQNTGEHYAQINCRPVIGDLNELAEWDVFCRRTGWNGGAAVHIDTGMNRLGLTLAEAQAIIPRINAGDHGITLVMSHLVSAEQLNSPVNAKQLASFRGIASEFSGVPAALANSSGIFLGAPFQFDLVRPGAALYGVNPTPEADNPMQPVVDLKARIVQIRNVERGESVGYGGTWTARRPTKLAIIAVGYADGYFRAASSNDGTRGAEVIVAGKRCPVAGRVSMDLIAIDITDLPPNAARRGHLVTLIGEGITVDELAHHFGTIGYEVLTSLGHRYARVYKGGNVVEPLAKPAAEQPSSPPPVEQPASPPPLPS
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Sequence:
MAILNILEFPDPRLRTIAKPVEVVDDAVRQLIDDMFETMYEAPGIGLAATQVNVHKRIVVMDLSEDKSEPRVFINPEFEPLTEDMDQYQEGCLSVPGFYENVDRPQKVRIKALDRDGNPFEEVAEGLLAVCIQHECDHLNGKLFVDYLSTLKRDRIRKKLEKQHRQQA
The following text describes a protein:
Function:
Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling. Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation. Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling. Promotes apical constriction of cells via ARHGEF18.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: Due to intron retention.
Subcellular Localization:
Cytoplasm. Cell junction. Note=Enriched at apical cell junctions.
Domain:
The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins); The PDZ domain is required for localization to apical junctions.
Sequence:
MDVTVSELLELFLQSPLVTWVKTFGPFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTNQRINKHVNNDVNLRIQNLTILVRNIKTYYQEVLQQLIVMNLPNVLMIGRDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESSDPASPAASQPLRSQAENPDTPALGSNCAEERDAHNGSVGKGPGDLKPKRGSPHRGSLDRTDASTDLAMRSWPSELGSRTCSTSATTTAPSNSTPIARHPGRTKGYNSDDNLCEPSLEFEVPNHRQYVSRPSSLESSRNTSSNSSPLNLKGSSEQLHGRSESFSSEDLIPSRDLATLPREASTPGRNALGRHEYPLPRNGPLPQEGAQKRGTAPPYVGVRPCSASPSSEMVTLEEFLEESNRSSPTHDTPSCRDDLLSDYFRKASDPPAIGGQPGPPAKKEGAKMPTNFVAPTVKMAAPTSEGRPLKPGQYVKPNFRLTEAEAPPSVAPRQAQPPQSLSLGRPRQAPVPPASHAPASRSASLSRAFSLASADLLRASGPEACKQESPQKLGAPEALGGRETGSHTLQSPAPPSSHSLARERTPLVGKAGSSCQGPGPRSRPLDTRRFSLAPPKEERLAPLHQSATAPAIATAGAGAAAAGSGSNSQLLHFSPAAAPAARTKPKAPPRSGEVATITPVRAGLSLSEGDGVPGQGCSEGLPAKSPGRSPDLAPHLGRALEDCSRGSVSKSSPASPEPGGDPQTVWYEYGCV
The following text describes a protein:
Function:
Controls the rotational direction of flagella during chemotaxis.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MAADEKAPVEGAPKDKKKLFIIIGAAAVVIIALAVVFLGGGKKEKGKEGEAEAKVEQKAEGGHGGGKEGAAGAVATAFALEPFIVNIYDGQELRYLRVKVEFETATPDAKAEIESRQAPLRDAILVLLTTKTLQDIQDLQGKNQLRDEILVAANKILPPGKVTKVYFTDFVVQ
The following text describes a protein:
Function:
Involved in parasite invasion of erythrocytes.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MRKLYCVLLLSAFEFTYMINFGRGQNYWEHPYQNSDVYRPINEHREHPKEYEYPLHQEHTYQQEDSGEDENTLQHAYPIDHEGAEPAPQEQNLFSSIEIVERSNYMGNPWTEYMAKYDIEEVHGSGIRVDLGEDAEVAGTQYRLPSGKCPVFGKGIIIENSNTTFLTPVATGNQYLKDGGFAFPPTEPLMSPMTLDEMRHFYKDNKYVKNLDELTLCSRHAGNMIPDNDKNSNYKYPAVYDDKDKKCHILYIAAQENNGPRYCNKDESKRNSMFCFRPAKDISFQNYTYLSKNVVDNWEKVCPRKNLQNAKFGLWVDGNCEDIPHVNEFPAIDLFECNKLVFELSASDQPKQYEQHLTDYEKIKEGFKNKNASMIKSAFLPTGAFKADRYKSHGKGYNWGNYNTETQKCEIFNVKPTCLINNSSYIATTALSHPIEVENNFPCSLYKDEIMKEIERESKRIKLNDNDDEGNKKIIAPRIFISDDKDSLKCPCDPEMVSNSTCRFFVCKCVERRAEVTSNNEVVVKEEYKDEYADIPEHKPTYDKMKIIIASSAAVAVLATILMVYLYKRKGNAEKYDKMDEPQDYGKSNSRNDEMLDPEASFWGEEKRASHTTPVLMEKPYY
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MDQWGRRSLYFPASQPQSEETPENNADHPPCLNGYPELTPTNVLPLASAFAGISLTGDQTRTPSFGIPPPAGSSIADFLDPTVDYLMGFSSNAELQQGLIRAHQNNGAHQNLNVGPDIRADILRRMHPWYPQLYSDECWRWNYDVANYNGLHSKEPIPQFPILPCLNQNSSIISNGVSYNYNCTVVPSNLKNNQSVLLGDNDLRGKVVALAKDQQGSKILQAKLEKGNKEEIEVVLSEVIDCVTDLLKNQSGSYVIQKLFVVCNEEQRTTIIQAITRTNLQFVNICFSQHGARAMQKLLENLSTPQQTSLIISALTPVAVALANDQSGHHVLQYCVKTFSIEYTRHLLSEIANNCFTIATQKSGCCVLQSCVEFSHGELRDRLITEILTNAVHLSEDQYGNYVVQHLVGLKLPRVTETLLERLQGSFVTLSCNKYASNVVEKIILESGEVHSTKIIAELLRSPSASMLLVDPYGNFVIQTALQVSKGHIFNALCKLIYMNSASMQSNIYGKKILDRLCSKKEPLHCTRLYKRQV
The following text describes a protein:
Function:
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).
Subcellular Localization:
Nucleus.
Sequence:
MSLLATPMPQAATASSSSSASAAASASGIPITANNNLPFEKDKIWYFSNDQLANSPSRRCGIKGDDELQYRQMTAYLIQEMGQRLQVSQLCINTAIVYMHRFYAFHSFTHFHRNSMASASLFLAAKVEEQPRKLEHVIRAANKCLPPTTEQNYAELAQELVFNENVLLQTLGFDVAIDHPHTHVVRTCQLVKACKDLAQTSYFLASNSLHLTSMCLQYRPTVVACFCIYLACKWSRWEIPQSTEGKHWFYYVDKTVSLDLLKQLTDEFIAIYEKSPARLKSKLNSIKAIAQGASNRTANSKDKPKEDWKITEMMKGYHSNITTPPELLNGNDSRDRDRDRERERERERDPSSLLPPPAMVPQQRRQDGGHQRSSSVSGVPGSSSSSSSSSHKMPNYPGGMPPDAHTDHKSKQPGYNNRMPSSHQRSSSSGLGSSGSGSQRSSSSSSSSSQQPGRPSMPVDYHKSSRGMPPVGVGMPPHGSHKMTSGSKPQQPQQQPVPHPSASNSSASGMSSKDKSQSNKMYPNAPPPYSNSAPQNPLMSRGGYPGASNGSQPPPPAGYGGHRSKSGSTVHGMPPFEQQLPYSQSQSYGHMQQQPVPQSQQQQMPPEASQHSLQSKNSLFSPEWPDIKKEPMSQSQPQPFNGLLPPPAPPGHDYKLNSHPRDKESPKKERLTPTKKDKHRPVMPPVGSGNSSSGSGSSKPMLPPHKKQIPHGGDLLTNPGESGSLKRPNEISGSQYGLNKLDEIDNSNMPREKLRKLDTTTGLPTYPNYEEKHTPLNMSNGIETTPDLVRSLLKESLCPSNASLLKPDALTMPGLKPPAELLEPMPAPATIKKEQGITPMTSLASGPAPMDLEVPTKQAGEIKEESSSKSEKKKKKDKHKHKEKDKSKDKTEKEERKKHKKDKQKDRSGSGGSKDSSLPNEPLKMVIKNPNGSLQAGASAPIKLKISKNKVEPNNYSAAAGLPGAIGYGLPPTTATTTSASIGAAAPVLPPYGAGGGGYSSSGGSSSGGSSKKKHSDRDRDKESKKNKSQDYAKYNGAGGGIFNPLGGAGAAPNMSGGMGAPMSTAVPPSMLLAPTGAVPPSAAGLAPPPMPVYNKK
The following text describes a protein:
Function:
Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3'. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17. Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus.
Sequence:
MDAAANKRGRGKGTRSTGRTVAAAVAVGGGAAANSGTNSPIVVSPSVVTLERRSTLPIPSITGNSSSTVLGVAANNATATASTATTTTASAPSIQRKLLRLAGKRHTGKGVSLGATTSKLACSSRTHLVRKALPVSGAVVGSVADRLHHRHGGVVPPIISTATANRNSANEAKLGKHHHPLPHQQNGYVAAAGSSYAPIVPYGPPGLLDGAETHQAGVAAVAASTRMVATSVSPLSPQTLSPSTGSSSPSTISPGVSLAASPLASCTGRQNAPAGGGARTANSNRGATASSVPFRMAPGTDGSFSVAGVPPALISSRDGKIQLQIVTQPEQQHRARYQTEGSRGAVKDRSGNGFPVVRLVGYNKPAALLVYIGSDVGRPTPHIFYQACKVSGKNSTPCVERILEGTKYIEVQLKPENNMTVTCDCVGILKERNVDVEYRFPDQTASRTKKKSTRCRMVFRTTITGEDGATETLQVSSHQIICTQPPGVPEILKKSLISCPVEGGLELFIIGKNFLKDTRVVFHRPKAVPAHSAFTRTAAAGAAWEHAVAPDKEHLNQVHLICKVPPYERQDITEPVTIKLYILSSGKKSETHDFIYTPKGEHTALSAATTVATIPGRRNRLGTAVGQQQQQQQQPPQHQQQQPPPTSHNYFSELAGLGNNGAGVQNGGNVTAVPNVDGAALANAINAIAATAAGMGELPGPNGAAGGRFVCNGNRTEAAVSPFDEPANVHASRPMFLRTSTPLEIEAKGMMPPPINVLPTGSIIPPQCHPGVLSLPSPNQPIQPAVDVFKPELVEPECSRSHMADEESLDQFAVKASLARFGASVENSLDGILFAPVPAEPSILYRRRSVRQPSMEMEDSCSNMSLLANDSRMMDLPSAGGAAAAAAAGGGGSSGGGSLSIGSHFDTVMNIATLTSFCGSLPVAPMETNYMGGEPLGTAKPPPLPVDCDIKSIIKTEPQTPHASTTPVNMQLDQLLAAFRRVQRRDCHADRGGNVCCSSNSSSSSNNNSSSNNSSSRNSNNSNNNNNSNNSSSNNSSSNNSSSNSSNNNSSSSSSNNNSSNNNNNNNNSSSSNSSRNNTSNNSNSSSSNNNNSINKLNNSNNNNCSSNNNNCINKLNNNSNNNNSCSNSINKLNNNSSNNCSSKHC
The following text describes a protein:
Function:
Redox component that participates in c-type cytochrome biogenesis in the mitochondrial intermembrane space. May play a role in the reduction of heme prior to its ligation to apocytochrome c by cytochrome c heme lyase. Has oxidoreductase activity in vitro.
Miscellaneous:
MISCELLANEOUS: Present with 2730 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Sequence:
MLWKNYVLSSSRITRRLHKSPRKSSFSKNFFITGCLLTVGAVSSYLTYRYTSERENKHELSPSYFVKYKISHKRDIDSSHFLLEVTPLFKQKVNIWSLMTAENLWSVEIKQPEVMVVRNYTPLPLKFNPASKEIEILKDGDNADGKLSFYIKKYENGEVARWLHHLPKGHIIEIRGPFIDYEFPHLPNELKRSRDCLYMDNRNERGNNVRENSQFIYQPYDIMMFTAGTGIVTALQLLLTESPFRGTIKLFHTDKNIKQLGPLYPILLRLQASNRVQLKIFETDRQTKQDVLKSIQKSITKPYPYKGLLPFSNVNNKNIMPVLALVCGPESYISSISGRKYDLNQGPVGGLLSKEGWNSDNVYKLS
The following text describes a protein:
Function:
Involved in apoptotic DNA degradation.
Sequence:
MIRQIILIVSLIGISNAAYQCKDNNGSNVDWFVFYKLPHLWNHPDNVPISNGTGFLYFDVNNKNWKLMPQGMDVENNAVYYTLQQYYNSNMNTTFSYMYNDEWPDSTIWSNSSGHAKGVTVFDQYTGFWMIHSIPKFPSKDMFRFPSNAHYYGQMGICISYNTVSLATIAQQLFYYNTFTYQFNLPQSFANQFPVLSQLKNKEYNKSPPLTSTKVLKSLGGQHFRHFAKTGEWGKDLYSDFVGPTLKSSIKVETWNHQSGDEYNLPSVCDPNHVQSTMSAKYIRLPYAIDYSSYEDHSKFVVAYSESSSKPPIPYVCIGDINRQSHQIHRGGGTMCIYDQETYFQFANIISETVPCTKATAEKATLTVLLIAIITFFK