lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mediates endoplasmic reticulum to Golgi transport.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Single-pass type IV membrane protein.
Sequence:
MQTRRRLHQTDQQDYSSSSTYTIQEDQQGGAGAGSVGTGTAGGSVGLLAQSLVPPPTGHEAAIHIGDNYQSGDSISTPDYSDDKYGKAARQWNLRAFSGHALRTLSAAAAVVTGNQPGINNDSQSNYSYPASIPTSSQFYQSKEEPQETEPEPEIFVMAARDRTGEFANAIRSLQARNITRAVNIRDPRKAKQVQSYSEFMMVARFIGKNIASTYAKLEKLTMLAKKKSLFDDRPQEIQELTYIIKGDLNALNQQIARLQDISKDQRRHTNGKHLVSHSSNMVLALQSKLASMSTDFKQILEVRTENLKQQKTRRDQFSQGPGPLAAHTVSPSTAKQGSLLLSEENQAVSIDMGSSDTTPLLSTQTQMAIYDDSDNYVQQRAETMQNIESTIVELGGIFQQLAHMVKEQEEIVERIDTNVADAELNIEAAHGEILKYFQSVSKNRWLMIKIFGVLIFFFLFFVVFMS
The following text describes a protein:
Function:
Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MFPARRKPRLPWEDSRSRLPLGMAPRRCTVFRLFFACLVLGFLSLLWLQLSCSGDGDRRERAWGEEAAAAPGSQRACDPGPVHFEEDPSWDPHRLALLVPFRERFEELLVFVPYMHRFLSKKKIRHHIYILNQVDHFRFNRASLINVGFLESGNGTDYIAMHDVDLLPVNEALDYSFPEAGPFHVASPDLHPLYHYKTYVGGILLLTKQHYRLCNGMSNRFWGWGREDDEFYRRIRGAGLQLFRPSGITTGYKTFRHLHDPAWRKRDQKRIAAQKQEQFKVDKEGGLSNVRYRVDSRTALTVGGAPCTVLNILLDCDPAQTPWCSSG
The following text describes a protein:
Function:
May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
Sequence:
MYTVLHIEQSDFFCKMVENILREKNYDYIATDSFNEAYNLIKEYDIDLIITSLYGKGGDIEDFIKNIGYMDSNEIPIFIVTSDNDHEKKKNLLNLGVFDYLLKDDLKEEITKHVDAVFQDDEYMKNLKEAKIAIIDDNSFDCTLEKDMLARYGIQNVDYYNSGKELFNSNKKYDMYLIDMVLENEFGKTLIRQIRRNNINSSIIAVTVLDNNKTLSNILNCGADDIINKPLDENLFISKLKSNIRIYTLNKKIKSILKEMKNK
The following text describes a protein:
Function:
Baseplate protein that is located next to the tail tube (inner baseplate). Involved in the tail assembly. Involved in the tail assembly.
Subcellular Localization:
Virion. Note=Present in 6 copies in the baseplate.
Sequence:
MLFTFFDPIEYAAKTVNKNAPTIPMTDIFRNYKDYFKRALAGYRLRTYYIKGSPRPEELANAIYGNPQLYWVLLMCNDNYDPYYGWITSQEAAYQASIQKYKNVGGDQIVYHVNENGEKFYNLISYDDNPYVWYDKGDKARKYPQYEGALAAVDTYEAAVLENEKLRQIKIIAKSDINSFMNDLIRIMEKSYGNDK
The following text describes a protein:
Function:
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MNLRALAAKAIFDVLEKGVSLSVALPEQQKHLASGKDKALLAELCYGVMRTLPQIEKRTAECLAKPLKGKQRIIHQLLIVGCYQLYFTRIPSHAAISETAEACRQLKFEGMVKVVNGVLRNIQRQLTPLSNESETLSYNTPGWLIKRLKTAYPGNWQEIIQQSHERPPMWLRNNRLSQSRDEYLAALDKLEIDASAGLSDDAILLAAPKDVATLPLFLEGAASVQDGAAQWAATLLAPQANELILDACAAPGGKSCHLLELEPSIKLIAVDFDAKRLERVQQNLDRLSLKAEVIHGDAANIDSWWQGEQFDRILLDAPCSATGVIRRHPDIKWLRKNHDIEELAELQRQILDHCWKWLKPGGTLLYATCSILPQENRDQISAFLARTADAKLDTLVQQASSQDIGWQITPGQHNMDGFYYARLLKATH
The following text describes a protein:
Function:
Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSSNGSDLGHNNRRNEKGNPDSVHSSMRGSMSSTRRKSINFQNQLQLALESNECDVMYCSLSSGRFRAPNGENFPPHGGKLKLSPLEKYDDANRGVPPPSPAPNSDCFATCVANQLPSQSCSVGSAKPETSVMQKHGMAGNGMVGSGMSGNGMAANGTNYHQRGVSPNSRYRLERYRESQSTPQSKLMDNMGGMPSAVPSVSATRLLLPSNVPLPLAQCENYNAYLGSTVHTPVKRYVPTPPPAMELYSDLSISSSPAANLPTPAAAVASSASTSASAMQSQYANMPYNYRSKCCHSEASHGSLSRTSQTYASCSPACTSPSPAPSTSMSMVFSAASSCSPIMTATSSARSGNHRGDDSDSVIVVPPGGGAMAQIEAENPSGTCLHCNTVRRTTGVHQTTQTTGPISPVPISLPVPMAMPVMSGLNEQMPSQSLESSMVSVQAKRLEGGGNMAVPPGSNQHQLYRSQMASNPRLQHIHHQTQQHQSLQVLPQPQNHHLSCKKRIGMYMRRTTSQFFGVEPSTEAADCALWQGRHRRLAIRCFGMFDTELEYHMQQAIGGGNEDAGQSNGTNGNYAPDRPDILPVQDAIGMDMTMSGDSRRQKCYTNRDFLAGEFVERKASVGYMFVAMVSYLVHMFNKRRPIQMHRVRCPWQWSRSFAPIHVQSHSNQQTDADGCLTDGLEAIIDDEVFFDSPCEITTSAVNDESSDIGRQAAKPRPCADQSGVGVSVYMAERQQNGWRTSALNSGGNATSDINLTGDQSSHQPGAAHIPLCSSVSSQMQPAMRSSHSTTSTCNRGNRITAQLLDGVLENSRRPPLRCIKYFSVNDLDDRTDHRPFFTYWINTVQVVVLILSIICYGIAPIGIGSEQKTGQVLVTSLSLQTVQHVEQRNLWIGPRNIDLVHMGAKFAACMRRDIKITEVVTKTRRHERETACCIRNDDSGCVQSSQAECSIRGLYPTKSISTWKKWSPSESGPGGRISGSVCGLDPKFCDAPASIAPYEWPDDITKWPICRKTNSFTQRYRYKDHTSEHMVCEVIGHPCCTGLYGECRITTREYCDFIKGYFHEEASLCSQISCLNNVCGMFPFISVETPDQLYRLLTSLCMHAGILHLAITLIFQHLFLADLERLIGTVRTAIVYIMSGFAGNLTSAILVPHRPEVGPSASLSGVVASLIALLVWMHWKYLHKPHIALFKLLLLCSVLVGIGTLPYQLNFLGLLAGVICGCLLTMSLVPFTTFSKYGRKKKINLIWTCVLFHVVVYTAMIVTFYIHPSEFHSISFVDMFSNSNGYDNFTNADHHGVDVVSSNTRYSQTQNSQYYYHHHSDDIIRKSVTFTEKALVSHILYPTAPRKTSAQQWQEVEYSRSFNHLSNYSDRIKKSIGNISKLKQVFTSPIRFSNKNNHSNLMTELTSVHSENKQKYLGYINNNTEFNVL
The following text describes a protein:
Function:
Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MSLRPSTAPPIQDMPPPGGYKKLDFGRYLPDRGPKGWQLWAGATTLILYGYYQVGKTNQAKIQQKMQERKVRYALAPLMQAEADREYMERELVGLRKEAEVMKGV
The following text describes a protein:
Function:
Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MEERELNLANKELTSLLDVPLGSILTSLNLHCNLIPRIEGLTSSWNLRNLDLSSNRISKIEGLSSLSSLRTLNLSCNLITKVEGLNGLVNLTRLNLSCNQINNLTGLLYLHGTEYKLKHLSLHGNHLDSIDHLLQCLLGLQGLRNVTLRRDGQSNPLCASAGFWDAVMESLPQIFVLDGLDRLRHPSSPGLSSICDIPGLEDYMDFLLSSDTSHHEKVKGAVSPPRSGAGTHTSSEEVAQPTSQPVGRRSRTLSSSGPDPADADNEERIRKLEHQVSRLIQQVPTGEKPANLSRTAGKPLKAKRDTDRVSESDGDSGKENRRRSGIPTHHTVPTSSTTPQETKSSRSDSDQENRRLRTLKPAGSRRKAGGAGRMGGAVQPKEVLLRAAKVPEDVRSRSKQEEETYRTIVEERDQERERRWKAEQAVRRLAEELKSLQTKVSEEKDLQSMALHTTDRLKDLLLKERSGRSELQNRVEELEGRLLSLIQQLEVTRSNEEKSKAALQRAEESISHADALRAGQQAEEMKRRQDMENKAAALKRELDIQRAAVNQHKEKLQQLHELLASREQEHRKQLDLRLQPGGADFREAVAQQVSSAERRHAQREAELQEKVAEGRKRYAALEDEFRLALTIEATRFSEVKEAYDRLTEEMVEVRAALSQWQQKEKRSGSLVQELTAVVKEQKSRIAELIKAKKDAVCGLKSRLRSLEAEVEGDRRLDLQLEVLKKEKARLLSQVTAQESVIDGLRSERRIWGQELAQQGASLAQDRGRLEARIEVLASELEAQRKQADRNQDALKIKTKIVDDQTETIRKLKESLQERDDRIRRLKNEAAEAQKRLHLQLEEDRVQQAELQERLERLSLRKEELKQQLEDKEAELHEVKTSHRESRRRWQEKEDLLTQLEVQVKGMKENFDSKERQLLEERDKAADAHKAALQKLRRADDAFRAQLESVHAAHRAELLQLADEKQQQTERANRKVLEVEEEMRQLLQETQTSKRVMEEKVRRLSSVLKDFHS
The following text describes a protein:
Function:
Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA.
Subcellular Localization:
Cytoplasm.
Sequence:
MADLDDIKDGKDFRTDQPQKNIPFTLKGCGALDWGMQSRLSRIFNPKTGKTVMLAFDHGYFQGPTTGLERIDINIAPLFEHADVLMCTRGILRSVVPPATNRPVVLRASGANSILAELSNEAVALSMDDAVRLNSCAVAAQVYIGSEYEHQSIKNIIQLVDAGMKVGMPTMAVTGVGKDMVRDQRYFSLATRIAAEMGAQIIKTYYVEKGFERIVAGCPVPIVIAGGKKLPEREALEMCWQAIDQGASGVDMGRNIFQSDHPVAMMKAVQAVVHHNETADRAYELYLSEKQ
The following text describes a protein:
Function:
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
Miscellaneous:
MISCELLANEOUS: In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
Domain:
The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC; The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
Sequence:
MSSFDIFSPTASVSGKFFLEASAGTGKTFTIEQVVLRSLLEGSIEQTKNILVVTFTNAATNELKLRIQASLKQALSLFSQALSHPGTPLPPYISSSETKVKQLYMKIRNSLATLDEMNIFTIHGFCRFTLEQHFPWIQPIQPSSIFSEPQTIQQHILDYLRKNLWDTVLSPKQYAFLSYHHRATTQQTRHLIERLLQDYTSTPNLALSPLSITLQKLKAWVSRYQHLAPLSLEEMQAFSLRFKQSDLSIERELPAFVQQFETNPYSLDMLFFPGMVQKFQEENRNKKKLSAPASPLDPFFQDWIQLAHPFCQKEPIFHTLLKSVQQHLKTHCAQSYSHDESIATLESLLAHNDTVVSQLRKQFQLVLIDEFQDTDKRQWQIFSKLFASPDYSGSLFLIGDPKQSIYEWRNADLPTYLQAKHSFPKEAQLILDTNYRSTPELMQALNHLFSLPTPFLETPQNILYHPLHSKGSAEISYSEFSPIHFFSSEDIQEETLWISKTASYLRSAYSIPFGNMAVLVQDYPQALKLITHSTIPMAYCKEKRIFDRTESPYLLILLLEALLYPENQQKIQAILMSRLFQLSSTEIHQHLKTFSSLFFTLNRHLYHYSLLATFYKLMGENVLSQTIGETLLQTPLGDIIFQELEALCLYLDKTTENPHHKLLHLINILITGKYDEELSFSSQSNDENMIKITTVHSSKGLEYDVVFCSCLNKAKEKTPSVHMREMYVACTRAKKFLFIPFSPIEKRSLSTKKLSALANYANVTKHHSVPHLVETLTSSSPELFSSSFQPPESSLTPDRERLPQQTYFSLPHLPSRTIHSFSSTVENLHFSEPIQELSPSLLFPGGSLTGTLIHKLLESLAGNFAACFEEIFNKAQTLLKNTPLEGYESIIAEKICTVFSTTLPFSSGSFALRNVHPHNIRAEETFLLQEEGELWQGIVDLFFEHKDRFFIIDWKTSFLGDETSCYSPDQLHLYIQRQGLDRQERLYRKAAKRFLHQFNSLLQVEMAFVFIRGLDDKGNGFLQPGR
The following text describes a protein:
Function:
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSHQQKQPCTAPPQLHEQQVKQPCQPPPPEPCVSQVKTPCDTKVPEPCHPKAPEPCHPKAPEPCHPKAPEPCHPKAPEPCHPKAPEPCHPKAPEPCHPKAPEPCHPKAPEPCHPKVPEPCLPKAPEPCQPIVPEPCPSTVTPILAQQKTKQK
The following text describes a protein:
Function:
Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.
Subcellular Localization:
Cytoplasm. Nucleus. Note=May translocate to the nucleus after heat shock.
Sequence:
MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEALVDYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFLKDISTTLNADEAVARGCALQCAILSPAFKVREFSITDLVPYSITLRWKTSFEDGSGECEVFCKNHPAPFSKVITFHKKEPFELEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGDSSKVKVKVRVNIHGIFSVASASVIEKQNLEGDHSDAPMETETSFKNENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLKKGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTVYEKFITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYMEHEERPKALNDLGKKIQLVMKVIEAYRNKDERYDHLDPTEMEKVEKCISDAMSWLNSKMNAQNKLSLTQDPVVKVSEIVAKSKELDNFCNPIIYKPKPKAEVPEDKPKANSEHNGPMDGQSGTETKSDSTKDSSQHTKSSGEMEVD
The following text describes a protein:
Function:
Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
Subcellular Localization:
Periplasm.
Sequence:
MKQIKAKIFNNFVLLIVFCLTFLFISSSFAFDTAFLANLLSNEIKKSPIATEVQVGQIKFIGYEPHENCNPENLKIREIKRPNAAEFTFKCGNRQYRAIANYEVLTRVYITQIPLKRGEVITEEKIMEIKQPLSRLPVGAITDKNLLIGKVVKRSLTRGLIIKEDYLYSGMPVKKGSKVDVIINTGQVMIMTEGVLKSDAVVGGNARVQCFQTGKEIVGKLVGKDKVRVSL
The following text describes a protein:
Function:
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis; Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has very weak wax synthase activity, incorporating palmityl alcohol into wax esters in the presence of palmitoyl-CoA.
Sequence:
MKLLSPLDQMFARMEAPRTPMHIGAFAVFDLPKGAPRRFIRDLYEAISQLAFLPFPFDSVIAGGASMAYWRQVQPDPSYHVRLSALPYPGTGRDLGALVERLHSTPLDMAKPLWELHLIEGLTGRQFAMYFKAHHCAVDGLGGVNLIKSWLTTDPEAPPGSGKPEPFGDDYDLASVLAAATTKRAVEGVSAVSELAGRLSSMVLGANSSVRAALTTPRTPFNTRVNRHRRLAVQVLKLPRLKAVAHATDCTVNDVILASVGGACRRYLQELGDLPTNTLTASVPVGFERDADTVNAASGFVAPLGTSIEDPVARLTTISASTTRGKAELLAMSPNALQHYSVFGLLPIAVGQKTGALGVIPPLFNFTVSNVVLSKDPLYLSGAKLDVIVPMSFLCDGYGLNVTLVGYTDKVVLGFLGCRDTLPHLQRLAQYTGAAFEELETAALP
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MSEKKQLVDLGFLEEDDEFEKFPAEDWADLDEDEDAHVWEDNWDDDNVEDDFSNQLRDVLSVLS
The following text describes a protein:
Function:
May transport inorganic phosphate (Pi).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MELALEFFRRLDAELNRVNRFYKLKEEEYTLRAHTLQLQMATLLELRKALARDGGKSPGTGVCVSDAKDENKSEAILDVWSIPPGQEGAISKKQVQHAEKLLRTAFADFYRGLGLLKSYSSINIMAFSKILKKFDKVTGWSVSATYLRAVETSYFASSEKVVKLMDRVENIFTLHLAKRNHREAMIYLRPLQDSSSNFLSFFLGIFTGCSVALLSILVLKGIIPLRWESGVNTHGEHMRALISVSSTVGLVLLHLYMYGWNVYLWRGARVNYALIFEWAPGTELQYQQVLLLSTGLTSLWMLALIVVKLYPTLPYSDLVPFLMFLVILVILFLPLDFCYRSTRVVFLRCMIQIMSAPFHKVVLADIFLADQLCSQVTAMRNIQFLICYYFEGYFDLQDKRACTSQCPTFRNLQYVVAMLPSWWRLMQCARRWMDDGEVQQVLNGGKYLSALIAAVVRVAYVQSETGGWLIVYVACSLVSSLFGVYWDTVRDWGLLQAKSANPWLRDHLLLKHRGVYYISMVTNIVLRMAWLFAVVVEETSDLDRNTVDLVLATLEVIRRGHWNFYRLEYQHLHNFGDFTALKQMALPFQDSSIQACR
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and cell cycle control.
Subcellular Localization:
Nucleus.
Sequence:
MNEKEELHLYHVSLQKQRNYVHSCIGHFVDYRHHHIRAQGGSVEGGKKGSKWRKQLQICMATQTQVELYDVEEGRLRRLFTRTVFGTITGLSSVVADGRSVLIVVGDSGKMSVLRFKYEGGRVRLEALFNEPLSRSGVRRLSPQAHVSVDPQGRCVLLSAMERNKVCYLMDVKQGELQVSSPLEANRPNYVTMQTAACDVAFDNPIFASLEIDLADGAKYLFFYMLDLGLNHMAKVADFELGDGSANFIMSVPDLEQYGINTKAGGPDDGDPDAIVPFVLMGFDNYVSLKDLRGRYDINVQIPTRKLSQKTIITAGTVQKLKRDFFMLLQSNHGDLYKVKILPDEKTASPVVTISYFDTIPQAQNLHIFKHGYMFANSEYGNSYLYQFENLDDEEESMLTSVMPGRRLIIEPRTVLKNLLVADKLALVNPILSSQLTERVPLTIATSTLGDVRLFTAGVNFMDIISSPLPAAPLDIWTVATNGSRFHKLLFIALQESTMILKIAAGTVEELELPHNPFVIAQDKTVLIAHMGGQSIIQVTENKMVHIIENRDESYESKLEWFPPAGICILKASSNSTQLILALSNNEVVYFEIGSNESLNELQDRIEVEERITALAIGNGNRSDYMIIASVDSTVKVYSLKVQDQANFLEVVSMQVLVSPASSLQLASSGGSLCLHIGLDSGVYVRSKLDRNTGELFDVRTKYLGTKPVEISLLLDMNPYINEEVDDEGEEEEEQDDEESLGGPHSRLVPCVVLHSGKTWISYELDSSLFIRPLLNDQSLKRVAQFTSNEIQRNGCCSISSAGFLVIGRIGTFRNNDCWFQESSLALPDSEDSVNGNELENDEKDPDALLEEKQKVNSSIGKLIIPDPDDIKLFYYCEYNEVENSCRVSLFKQGISYKHENSTEAFQLIPDCRPSTATIARFGLDMKHLVISTVNGVLKTFVIRITKAANNRRFELLALHDTVAGSTIHAMCPFHDKLLVPLANAVVLYGLGKKQLLKKSISYLPTSITKIVALDQWNGTRVAVGDIHESVTLLHFDERKNQFIPVADDVTKRHVTVVKFVDECTVIGGDRFGNIWLLRLPLEYDRLIKEGVDSYLLTLNTGIPSNIRECVFKWQLLNHFYINDIPMSFHLIASPQMADRASILYAGLQGTIGYLIPLITRREIEFFDLLEQAMRDADHLFYLDQENRLNDTSELNDGADEEGSVIDRRFPSVQKKRKIPEGAYSLVGRDAMMYRSYYNPVRHVTDGDLCEQFLELYPSEKNFLAARVDNRSVQEIERRINDMRTNCM
The following text describes a protein:
Function:
Transcription factor that activates the genes for FRE1, FRE2 and FET3 in response to iron deprivationand thereby plays a central role in iron homeostasis. Also required for the expression of LSO1. Recognizes the consensus iron-responsive element (Fe-RE) sequence 5'-CACCC-3' in the promoters of target genes (By similarity). Iron could interact directly with AFT1 and inhibits its activity. In high iron condition, the presence of Fe(2+) or [2Fe-2S] cluster leads to dimerization, which in turn leads to a decrease in DNA affinity (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 2730 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The CDC motif is involved in iron-sensong via binding to Fe(2+) or [2Fe-2S] cluster, which leads to dimerization and loss of DNA-binding.
Sequence:
MEGFNPADIEHASPINSSDSHSSSFVYALPKSASEYVVNHNEGRASASGNPAAVPSPIMTLNLKSTHSLNIDQHVHTSTSPTETIGHIHHVEKLNQNNLIHLDPVPNFEDKSDIKPWLQKIFYPQGIELVIERSDAFKVVFKCKAAKRGRNARRKRKDKPKGQDHEDEKSKINDDELEYASPSNATVTNGPQTSPDQTSSIKPKKKRCVSRFNNCPFRVRATYSLKRKRWSIVVMDNNHSHQLKFNPDSEEYKKFKEKLRKDNDVDAIKKFDELEYRTLANLPIPTATIPCDCGLTNEIQSFNVVLPTNSNVTSSASSSTVSSISLDSSNASKRPCLPSVNNTGSINTNNVRKPKSQCKNKDTLLKRTTMQNFLTTKSRLRKTGTPTSSQHSSTAFSGYIDDPFNLNEILPLPASDFKLNTVTNLNEIDFTNIFTKSPHPHSGSTHPRQVFDQLDDCSSILFSPLTTNTNNEFEGESDDFVHSPYLNSEADFSQILSSAPPVHHDPNETHQENQDIIDRFANSSQEHNEYILQYLTHSDAANHNNIGVPNNNSHSLNTQHNVSDLGNSLLRQEALVGSSSTKIFDELKFVQNGPHGSQHPIDFQHVDHRHLSSNEPQVRSHQYGPQQQPPQQLQYHQNQPHDGHNHEQHQTVQKDMQTHESLEIMGNTLLEEFKDIKMVNGELKYVKPED
The following text describes a protein:
Function:
Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. Binds to the 23S rRNA (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSWYPGHIEKAKRQIKDLLRLVNTVVEVRDARAPFATSAYGVDFSRKETIILLNKVDIADEKTTKKWVEFFKKQGKRVITTHKGEPRKVLLKKLSFDRLARVLIVGVPNTGKSTIINKLKGKRASSVGAQPGITKGIQWFSLENGVKILDTPGILYKNIFSEDLAAKLLLVGSLPVERIEDQRIFERAFEIFARSIGIESSFSEFFEDFARKRGLLKKGGVPDIERALMLFFTEVAQGKAGRVSFERPEDITPVQQEQTRGV
The following text describes a protein:
Function:
Glycosyltransferase required for the biosynthesis of heparan-sulfate (HS). Transfers N-acetyl-alpha-D-glucosamine to the nascent HS chain (GlcNAcT-II activity). Appears to lack GlcNAcT I and GlcAT-II activities.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MQTRKKYLFLTFLASWLLLFFFGREQLRRFTFFPRRNVAVRRSWPRWADRTLLHSFAEPWELQGSTDTAQPSPRARRVAQLSTSQGSRCRMESCFDASRCQNGFKVFTYPREHGEPMSESYSKILSSIERSRYYTPRPEEACLFVLSIDTLDRDPLSAHYVRGVEQRIRSFPLWNSGRNHLIFNLYAGTWPNYTEELGFDIGHAMLAKASFHSKNFRPGFDVSIPLFPREHPQRGGQRGWLHHNSVPPKKKYLLVFKGKRYLTGIGSGTRNALHHIHNGQDIVSLTTCRHGKDWERHKDTRCDQDNVDYEKFDYQELLHNSTFCIVPRGRRLGSFRFLEALQAACIPVLLSDGWELPFSEAIDWGKAAVVGSERLLLQIPSAVRCIRPERVLAFQQQTQFLWDAYFSSVDKIVHTTLEIIRDRLLPHRSRSHFLWNTLPGGLLALPDFSTHLGDFPFYYLQHGSGPSDKFTALLRAAPPLGSLSQPTLRLIQAVSRSQYCAQILVLWSCEKPPPPSGTWPQTAVPLTIIQGRTKLSDRFFPYAAIGTDAVLSLDEHSSLSTSEVDFAFVVWRSFPERIVGFSAWSHFWDPEQKRWGYTSRWTNKLSIVLTTAAFYHRYYHSLFTEYLPTGLQELVDSLAACEDILMNLLVAAVTKLPPIKVTQWKQHKEAASQPVKGTAAGSSRRFSQQQDCLNQLVDWFGSMPLVSSQLRLDPVLFKDQVSVLRKKYRYLEKP
The following text describes a protein:
Function:
Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome.
Sequence:
MHFSIPETENLQDKDGSYYQGYHVHINGNHHCTLRYKQLRHLHDQLKKLFSHDTIPEFPSKKLLPLTTLQLEERRLYLEKYLQSIALDHRISSSTFFHAFLRMAQNETHLSSDDQKIIHIRITLPGEEVISIPVTPIQETSSVIKKVAQHVGLPEELADYFALFIQDANEFNQYCLVRRLLNYESPFLAVKLSGESASLVMRKSYWDSIYDDELLKCPIGTKLVYNQFRDDHKRYWIQPNEQQLISLKRLIDQDKQHEVMKLARQIRFYGGVNFLPCITDFPTAGTPVSIHALNKELVFCYPDLTERSFRVTRMRSWRITTIVQVKHITHNSNVDHPKLELSFEYLLSKDRLQWITVDSAQVIFLSLCLQSMVEELMRKQQDGGGGSSFPQLADEVIQKLTFLGKHGNLLCISESTGKTRISKDPVKKSLGLKESIRVRFRNGRNHSFEEARIENHAFEDIRDEDL
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase). The cyclase preferentially catalyzes the symmetric cyclization of both ends of the substrate to produce dicyclic carotenoids. Beta-carotene is further processed to the acidic carotenoid astaxanthin.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTALAYYQIHLIYTLPILGLLGLLTSPILTKFDIYKISILVFIAFSATTPWDSWIIRNGAWTYPSAESGQGVFGTFLDVPYEEYAFFVIQTVITGLVYVLATRHLLPSLALPKTRSSALSLALKALIPLPIIYLFTAHPSPSPDPLVTDHYFYMRALSLLITPPTMLLAALSGEYAFDWKSGRAKSTIAAIMIPTVYLIWVDYVAVGQDSWSINDEKIVGWRLGGVLPIEEAMFFLLTNLMIVLGLSACDHTQALYLLHGRTIYGNKKMPSSFPLITPPVLSLFFSSRPYSSQPKRDLELAVKLLEEKSRSFFVASAGFPSEVRERLVGLYAFCRVTDDLIDSPEVSSNPHATIDMVSDFLTLLFGPPLHPSQPDKILSSPLLPPSHPSRPTGMYPLPPPPSLSPAELVQFLTERVPVQYHFAFRLLAKLQGLIPRYPLDELLRGYTTDLIFPLSTEAVQARKTPIETTADLLDYGLCVAGSVAELLVYVSWASAPSQVPATIEEREAVLVASREMGTALQLVNIARDIKGDATEGRFYLPLSFFGLRDESKLAIPTDWTEPRPQDFDKLLSLSPSSTLPSSNASESFRFEWKTYSLPLVAYAEDLAKHSYKGIDRLPTEVQAGMRAACASYLLIGREIKVVWKGDVGERRTVAGWRRVRKVLSVVMSGWEGQ
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MAGIKESFSGISDSGSRISISNKKKKIFLFLIASFLLVASVIGIVAGVASRKNSSKIPSSAHAILKSSCSSTLYPDLCYSAIATVPGAADNLSTQKDVIEISLNITTTAVEHNYFTIKKLLAHEKLTEREKTALHDCLEMVDETLDELHETAEDLKQYPNKKSLDEHAEDLKILLSAAMTNQDTCIDGFSHEQADKEVRNALLKGQEHVYHMCSNALAMIKNMTDTDMAEEKLKMGRKLGESTGEIDGFPGWLSAGDRRLLQASTVTPDVTVASDGSGNYKTVSEAVAAAPINSNKRYIIRIKAGVYKENVDVSKKKKNIMFVGDGRKNTIITGSRNVVDGSTTFHSATVAAVGEGFLARDITFQNTAGPSKHQAVALRVGSDKSAFYRCDMLAYQDTLYVHSLRQFYVDCLIVGTVDFIFGNAAAVFQNCDIHARRPNSGQKNMLTAQGRDDPNQNTGIVIQNCRIAATSDLQAVKSSFPTYLGRPWKEYSRTVIMQSTISDVIHPAGWHEWSGNFALTTLYYAEYQNTGPGAATANRVSWKGYKVITSATEALRFTVSNFIAGGSWLGSTGFPFSSGL
The following text describes a protein:
Function:
Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).
Subcellular Localization:
Nucleus.
Sequence:
MAGLDLGTNSYLHHHQQLHLRHDDGAGGSDDGQDALSPGGVGGSTAAGAGIGGSEVVGRRPRGRPPGSKNKPKPPVIITRESANALRAHILEVAAGCDVFEALTAYARRRQRGVCVLSAAGTVTNVTLRQPQSAQSGPASPAVATLHGRFEILSLAGSLLPPPAPPGATSLSAFLAGGQGQVVGGSVAGALVAAGPVVVVASSFSNVAYERLPLEDGDEVVPTPPPAGSDQAGGGMPFGVDPSGGSAGAGLPFFNLPMGMPPMPVAGHNGWPGAAGGVERPPFS