lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development.
Sequence:
MRFVSSRWRESAPNSERLLPLNKRKRRKRKCACSMTACWRGPSRFVFASLGSGCFRKFPVALLARGHSRGVKVLLGNQFKQDVCPRSAALSLVSRLSFVSDSGGVDMSSSEMSHRMVWVDLEMTGLDIEKDQIIEMACIITDSDLNILVEGPNLIIKQPDKLLDEMSDWCKEHHGKSGLTQAVRESKISLQQAEYEFLSFIRQHTPPGQCPLAGNSVHADKKFLEKYMPQLMHHLHYRIIDVSTIKELCRRWFPEEYKMVPYKKASHRALDDIQESIKELKFYRANIFKDSTEEKKCKVVENGENNKP
The following text describes a protein:
Function:
Substrate adapter of E3 ligase complexes mediating ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, and which is involved in various processes, such as ribosome recycling and reticulophagy (also called ER-phagy).
Domain:
The shuffled ATG8-binding motifs mediate interaction with both ATG8 family protein and UFM1.
Sequence:
MSEPAIARLIGEGVERPEASLPIDINYAKLTEWLVTRQKIPKDWHKRLQVIQAKAAEAVKELPPGTLSSLTDGADAPVDYMRAVEIRDKLASTSERTMFGGLQGPAATWDKIVKAYEKQFVYLGEAGQCLVQNVDFEIPYLRRNAAKLAGQLADGERKQGEYTRAAAACAAKYKEECKKLGISGAAVRAELRALAGELPGLLRGVVDSLHQPRLQEAAEYYAAFTRFAHAPRAGAPSSAKGPASSASAPPALEPESMLPVLFEIRNRRTAPPEAESGAAGAGASGQGGGIEIDWGDSGGDAGGAGVAAIDIDWDAPTAAPEGDAAAAAGPAVDINWDFDMADLAAAAGDDAGGTAAAPTADASAGPVGIDWDIEVDAAGDAAADANNRAGDVAEGEAAASLSGGGGGGASSGDPDDVAAARLERDADYRARLVDDLTELRAFLAQRKSDLAAGGSELTATALPDAVSSVDAAAVASMLGSVQAVLGQLGTPRFRQLLLIATSPRYLDRLEARLQRQAGAEAKMLAAAAEAVARQHEARAGLAAQAPRTAALVARCRRLKGVVERGIAASLGGKRSVNVLGEINNVLASAGQ
The following text describes a protein:
Function:
Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.
Subcellular Localization:
Endosome.
Sequence:
MSVHLKLSRPNRIYRPSELLEGKIIVKTQSSISHYGIRLTIKGSVNLQVRGGSAGVVESFYGVIKPIPIVKRTVEVQSSRKIGSGTTEIPFSLNLRQDEDLERFYETFHGADISIQYLLTVDISRGYLHKSLSATTEFIIESDKGDLLQRPIPPEMVIFYITQDTQRHPLLPELKSGGFRVTGKICTQCSLSSPLNGELTVERSAVPIQSIDIQLFRVESILHGEKIVTETSLIQTTQIADGDVCRNLTLPIYVILPRLLTCPTIFAGPFSIEFKVAVVITFQSELSKLQKKSDSRTPRLWLAMEMLPLELVRTM
The following text describes a protein:
Function:
Required for the processing of the 27S pre-rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSDDDGFQVENDSDNDSDKELQVAFEKGLLKDTVIVSTTNPKPKYINNKVGLEEALRNLKRDLPWQETLDICVEPAPLPYCLKDDDESDIKGDGKEEENDFKLENLFYRQAQNAVLKGLARLTAFNIPTKRPEDYFAEMLKSDLHMKKVKENILSLQAIKDKSEKAKKEREAKKVKKLADKEGRKEKKKEKLEYKNTLKKVRKKLNLGQRGKILNPDDLFEDTSDRKSVEVVYRKEQKIKQQHKQQQQMNNNKNNNDSSYIVPEKPMKANKKRMMKNKKFGFGGQKKRSKYNTRESVDEVQFKSFRSPAAIKKYKNKNKSNNRRNKKKK
The following text describes a protein:
Function:
Associates with SLC3A1/rBAT to form a functional heterodimeric complex that transports anionic and neutral amino acids across the apical plasma membrane of renal epithelium. Preferentially mediates exchange transport, but can also operate via facilitated diffusion. May act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MAMDSKKEIRLKRELGYFWGTNFLIINIIGAGIFVSPKGVLQHSSMNVGVSLCVWAVCAVLTLTSALCSAEIGITFPYSGAHYYFLKRCFGPLVAFLRLWTSLFLGPGLIASQALLLAEYGVQPFYPSCSAPILPRKCLALAMLWIVGILNSRGVKELSWLQTVSSVLKVGILGVISLSGLFLLVRGKKENVQRLQNAFDAEFPEVSQLIEAIFQGYFAFSGGGCFTCIAGELKKPSKTIPRCIFTGLPLVTVVYLLANISYLTVLTPQEMLSSDAVALTWTDRVIPQFTWTVPFAISASLFINLVINVLETSRVLYIASENGQLPLLFCALNVHSSPFIAVLLIISMASILIVLTNLIDLINYLYFVVSIWTALSIIGILKLRYQEPNLHRPYKVFLPFTFIALGITLSLVLIPLVKSPKLHYIYVFLFLLSGLVFYVPLIHFKVKFVWFQKLTCYLQLLFNICIPDVSDDHIHEES
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MPGVVDTPAGPSWPGLGFTVAHQKVELELDFASRSLKGKTEIIIHPHYKDLRYIRLNFRQGELKRVTVSGKVPLVKYTDPYESLQLYGPHYHQRLASKLDALLKTPSEPELTLTLPKSVRIDELDPFSVEAQDQMALRAPGLADDTEGPLSSKTAETSLPRFTALTVTIEFIVENIRDGIQFVGVENGDKRYPHAYTTNSLDHGTGCPLFPCVDDPSSRCTWEIAIRCPCTLGDVFERKPRDQSVSGTGTRLRSNHDRLAPDDEALDLSVVCSGELTDDIVDSKDSSKKTVSFASYSPLSARQIGFAVGPFEYVNLADFRESDQDEQLGQNAIPLHAFCLPGRGDEVRNTCFPMAKAIDFFSMTYGSYPFSSYKMCFVDDAPEDTLPTACFSICSSRLLFPEEIIDPMYDSTRAITHALAAQWIGVNIVPKEPADTWVTVGVAWYITDTFMRKLCGNNEYRFRLKLMSDRVCDLDYERPSVYDMGNILSIDPSEAKFIALKAPLVLFILDRRLTKASGKATMSRIISRLFLNARMGELPNGAVTSSVFQKTCERLGHAKLDTFFNQWIYGAGCPRFQATQRFNKKKLVVEMMIKQVQSDQPTARDLERDAFMRDVKEEIRNVYAGTIQPVFTGSMTIRIHEADGTPYEHIVEIKEGVTKFDIPYNTKYKRLKRNKRQKERAAAVIGADGNAEVQEDILLYCLGDVLQSEEEMQQWRLADWSKEDEERMGQESYEWIRMDADFEWICKLSLVMPGYMYLSQLQQDRDVVAQLESLQYMAAQREHPLISTIFLRTLMDRRYFYGIRVAAARALVKHAKEEINWLGLFHLEKAFQELFCLPGSPMTRSNNFSDRAAYVLQLVIPEAISKVRDVSGKTPMRVKRFLYDKLKFNDNSNNEYSDNFYVATLMKSLCHAMLGRVESRTDDLNNFDMDAVLEAQAEEQLEKDAIAEIDRYRRMDEWSSSFQNLYSRAALYCQMQLMQAKIAEVDVMQFLPYTRVGTYDLLRLDAFECLVELDIFKSPELLRWFIFTMSNDPSIWLRWQLHGLFGRALAPVAFGRGVINEPPPPTDGLIIEQESSTEVRQADLARRQTVTGALAALKAEVSGDQVLKECLWAACSSPIIGILELSEFTDLCRVIYDPVTSKRVTLKYPRYWAVKHHGRGRLQFYRTNKIRTSLNPSTTSSAKRKREDGTAMPAPSSGLRVTFKQSRPNPSNHHPSTPSAKTPGPSSGLGTPLQQRQPTKLHIPNFAAAQVHRQPPSHTPATPSTPGGGLKLKLKLGSQPKQ
The following text describes a protein:
Function:
As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex. May play a role in cellular response to endoplasmic reticulum stress (By similarity).
Subcellular Localization:
Cell projection, microvillus. Note=Localizes at the tip of microvilli. May associate with endoplasmic reticulum membranes (By similarity).
Sequence:
MSTRYHQAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKGTFSRSSPSNASAPGTFGSLSKGIKDTFKIKFKKNKDTAEQVGKEGRSGQRNVMEVFREEEEDSFSGDFKEKLQLSAEEDGSVHHESILNRPGLGSIVFRRNRISSPEDISDSKREFGFKLPSELLQRQGASEADEGAADEEGEENGLKDDLPWDDDEVEWEEDVVDATPLEVFLLSQHLEEFLPIFKREQIDLEALLLCSDEDLQSIQMQLGPRKKVLNAINRRKQVLQQPGQLVDTSL
The following text describes a protein:
Function:
Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
Sequence:
MSKFGVLVMGPAGAGKSTFCSALIQHLQTTRRSCFYVNLDPAAESFNYEPDLDIRELITLEDVMEEMELGPNGGLIYCFEFLLQNLDFLSQALDPLSEEYLIIFDMPGQIELYTHIPLLPSLVQYLSRQGPLNINLCAAYLLESTFVIDKAKFFAGTLSAMSAMLMLEMPHVNILSKMDQVRDMVSRKELKRFVNVDVNLLQDEIGGAEEPVEGDPSSKDTLLSGRSFKRLNRAVGQLIDDFSMVSFLKLDVQDEDSVAAVLSHIDDAIQFHEAQEPREPNDEQDVDYEDADI
The following text describes a protein:
Function:
Participates in the folding of proteins containing disulfide bonds.
Miscellaneous:
MISCELLANEOUS: Present with 830 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MLFLNIIKLLLGLFIMNEVKAQNFYDSDPHISELTPKSFDKAIHNTNYTSLVEFYAPWCGHCKKLSSTFRKAAKRLDGVVQVAAVNCDLNKNKALCAKYDVNGFPTLMVFRPPKIDLSKPIDNAKKSFSAHANEVYSGARTLAPIVDFSLSRIRSYVKKFVRIDTLGSLLRKSPKLSVVLFSKQDKISPVYKSIALDWLGKFDFYSISNKKLKQLTDMNPTYEKTPEIFKYLQKVIPEQRQSDKSKLVVFDADKDKFWEYEGNSINKNDISKFLRDTFSITPNEGPFSRRSEYIAYLKTGKKPIKKNHSSSGNKHDEL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLERNLTSMMSVEEPLPRPLTSLYIRLSILERNHMNMTYMAKSSVKIHISKVIIGFVLKRSLTNVCGKVLSQNSHLVNHQRIHTGEKSYRCHECGKAFTQGSRFINHQIVHTGENFPNVLNVARLLRMALNSGLTK
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MTEPQGPLDTIPKVNYPPILTIANYFSTKQMIDQVISEDQDYVTWKLQNLRTGGTSINNQLNKYPKYKYQKTRINQQDPDSINKVPENLIFPQDILQQQTQNSNYEDTNTNEDENEKLAQDEQFKLLVTNLDKDQTNRFEVFHRTSLNKTQVKKLASTVANQTISENIRVFLQAVGKIYAGEIIELAMIVKNKWLTSQMCIEFDKRTKIGYKLKKYLKKLTFSIIENQQYKQDYQSDSVPEDEPDFYFDDEEVDKRETTLGNSLLQSKSLQQSDHNSQDLKLQLIEQYNKLVLQFNKLDVSIEKYNNSPLLPEHIREAWRLYRLQSDTLPNAYWRTQGEGQGSMFR
The following text describes a protein:
Function:
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Sequence:
MTRLGLVVAEFNRSVTERMEAAAREAAADADAAITDTVHVPGAYDSPLAADRLARRDDIDAVAVVGAIVTGDTDHDHVIASATADTLTDVSLERDTPVTFGVSGPGMSGAEARERVEKGAAAVESAVSLTQEL
The following text describes a protein:
Function:
DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.
Sequence:
MTANSEFNKRRLENIKRNNELLKKLNLAGIPARIRSEAGIEDHRKASGGAVKKKQGKAPVKREAKPAPIPTRRSRRLRGEAADVEGEAGAGSDTAQNVKQEEEWKELKEARVVGDIKLSDLIKSEDDGELLEKFRRYADKSFSGGDFFEELQRHQKPNPEVQRLREEMRLQQYDVFDPKELAIVHERVTALCFHPSQEKKLIVGGDTAGTVGLWNVADENPDPEHPDSVPDITRFKLFSRNVSKIEVFPTDSSKILAASYDGALRSIDMQSLKSDELLHFQNEHGDTLGISDCQFSYDSPNVVMLTTLGGEFAQRDLRTKPDTMNIMRLSDKKIGCMAIDPSRPYSVATASLDRTLRIWDLRKTVAKPDWSQYEDYASHEVVSTYNSRLSVSAVSYAPIDHTLVCNGYDNTVRLFNARADLPSELQPDFTIQHNCKSGRWVSVLKARFKLNMDVFAIANMKRAIDIYTSRGEQLSHLETSTVPAVVSWHPMQNWIVGGNNSGKVFLFTDAPQE
The following text describes a protein:
Function:
Transcriptional activator of evening element (EE)-containing clock-controlled genes. Forms a negative feedback loop with APRR5. Regulates the pattern of histone H3 acetylation of the TOC1 promoter. RVE4, RVE6 and RVE8 are components of the circadian system acting synergistically to regulate flowering time, redundantly to regulate leaf growth, and antagonistically to regulate hypocotyl elongation; their action seems independent of ZTL and HY5.
Miscellaneous:
MISCELLANEOUS: Subject to temperature associated alternative splicing producing mainly non-productive mRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSSSPSRNPTNAEAPPPPPTSTDAVAEGSSKKVRKPYTITKSRESWTEEEHDKFLEALQLFDRDWKKIEDFVGSKTVIQIRSHAQKYFLKVQKNGTLAHVPPPRPKRKAAHPYPQKASKNAQMPLQVSTSFTTTRNGDMPGYASWDDASMLLNRVISPQHELATLRGAEADIGSKGLLNVSSPSTSGMGSSSRTVSGSEIVRKAKQPPVLHGVPDFAEVYNFIGSVFDPETRGHVEKLKEMDPINFETVLLLMRNLTVNLSNPDLESTRKVLLSYDNVTTELPSVVSLVKNSTSDKSA
The following text describes a protein:
Function:
The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
Subcellular Localization:
Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Golgi apparatus.
Sequence:
MATLQLLRAPLLCVLLWVFCAPGARAHDHGADVHHGSVGLDKSTVHDQEHIMEHLEGVIDQPEAEMSPQELQLHYFKMHDYDGNSLLDGLELSIAITHVHKEEGSEQAPVMSEDELVSIIDGVLRDDDKNNDGYIDYAEFAKSLQ
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MKQKETKTSQIALVDGEKLSITDSFASLFTLDEEEENDSVDNEEIKLTKEKHEKLLLLFWLHCKFPNGLEWLHSSSDLLPEQVSEWFNFYQKYRFKRGRNFNLSARESVTPIVEEPIVPEEPDNLEGVSEETPLKETSLELSEEEIITSKSPIPSPETIHKNIDVEEKETIEPTTPVKEVETTAHAEEEKGPLTPDSEYAARQLTEELANKSSQEEGVDKQLRVVEATEKEHEEDGNEENVTVTKPVEVATDQVESKEVKKKEVSETTEPTAPPVTVAEVLEIEDKVPKVDEVEEVHSPEAKVTENDVENVQSGIDIEKTIQLLNNQEIPSEQQIISVDKATESPVQEVAVDVNEKPVDEIVEPSKLQMENKLPSEKSPTIDRTGVEAPLFELSVSMPLTLIPPSKFSEPVKPELSSEAWLLRTEMSPLHLRLKNAHKYVLSDNWSHAYREEIVRQSLHHLTVAKEKGIWSFRQPKRQNEMPRLKTHRDYVLDEMQWMSIDFSQERKWKIILAHRMANWVMDYHQASDKCTVCTPASLSKNKKPYMQENEHQKDSHEETFNEQIVSHFNLNDNNNNKVLSIPRDSLQFYNAVFSDDIFVTTNSEQIQNCVLNVPMYGPPTENNEYCEEISEKYPITPVSRFAYAKTKLKSTCAKASRKRLFNQLELSPPESFMEKKARSDENQLDGNKIKDDNQKLSSVGTFSVRPPYPPSSKDIRPEAPWLPEEDELLLLLLRRYSFNWEFVASRLTPPGLYIPLAEKRTAWDCFERWIQVDPRAANVQLTGSHARLAQQKLDESLRHSDKVSQHLSLRDEGTPNHLIKHNSYFLLPTVSRHYRPITIFEAIRKILKKREFAKKPTMTKRAIAPSAASTEKLPPVPSPLELSRLKSEREAQIQQIQAQRNFAQLQSQNRALRPQNAAVAAGAQQHNQQLAAFQAVAASQNSSNNSSAGVSPIAGRMVPRLQPYAVSSSLKLTPEQIHQLQQRKQTVPTTERTQ
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSGCPLHRPPRPPTPHTTDLPLPPLPPAPARPEEWRPGACASWETTPPAGKGPHAPPFFSARSKDGRRTGSRDPGRSSLFPARRVLNPAASGSHSAIRPFIHSFIHSFLPSFLHSFIHSCVHALMHSCIHSFIHAFIPNNHGLCGALTRFTTRTTTGGSVLSGARKRQRRIETLRLHLSAWSSLPPAPEVNENFAIDLIAEQPVSQVESRVISCDGGGGALGHPKVYINLDKETKTGTCGYCGLQFKQHHHH
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MASRKRGRSEFEGGEEEEDFDAQLRKEYTQKVLQQQKLILVLDLDHTLLNSASFSKVDEEERLYLEKIYDWQEKAPKRRKLLHKVESLQVWTKIRPFAFKFLEEASKFFDLHIYTNGREIYAETMAKLLDPTGSLFKGHIFSRDHNCMKAMKDLDTVPGDESITLIVDDSDCVWPKKHHKNLIPVYDRYLFFRSSTGLFGLRESSSLTSKKKDEVATKATLAKLLEGLKRIHSEFFQESGCFAGDVRQTMREVKGHALSGCKIVICAKSQAAHELLWDSCQELGAECVVDIDDTVTHVVVASKQQPQGLELSAQAGKYLVWPSWIHTAHYRCCRPDEAAFLWRKLE
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Sequence:
MANILKTIIENDKGEIRRLEKMADKVFKYEDQMAALTDDQLKAKTVEFKERYQNGESLDSLLYEAFAVVREGAKRVLGLFPYKVQVMGGIVLHHGDVPEMRTGEGKTLTATMPVYLNALSGKGVHVVTVNEYLSERDATEMGELYSWLGLSVGINLATKSPMEKKEAYECDITYSTNSEIGFDYLRDNMVVRAENMVQRPLNYALVDEVDSILIDEARTPLIVSGANAVETSQLYHMADHYVKSLNKDDYIIDVQSKTIGLSDSGIDRAESYFKLENLYDIENVALTHFIDNALRANYIMLLDIDYVVSEEQEILIVDQFTGRTMEGRRYSDGLHQAIEAKEGVPIQDETKTSASITYQNLFRMYKKLSGMTGTGKTEEEEFREIYNIRVIPIPTNRPVQRIDHSDLLYASIESKFKAVVEDVKARYQKGQPVLVGTVAVETSDYISKKLVAAGVPHEVLNAKNHYREAQIIMNAGQRGAVTIATNMAGRGTDIKLGEGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMKRFGSERLKGIFERLNMSEEAIESRMLTRQVEAAQKRVEGNNHDTRKQVLQYDDVMREQREIIYAQRYDVITADRDLAPEIQAMIKRTIERVVDGHARAKQDEKLEAILNFAKYNLLPEDSITMEDLSGLSDKAIKEELFQRALKVYDSQVSKLRDEEAVKEFQKVLILRVVDNKWTDHIDALDQLRNAVGLRGYAQNNPVVEYQAEGFRMFNDMIGSIEFDVTRLMMKAQIHEQERPQAERHISTTATRNIAAHQASMPEDLDLNQIGRNELCPCGSGKKFKNCHGKRQ
The following text describes a protein:
Function:
Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.
Sequence:
MVAGSDAGRALGVLSVVCLLHCFGFISCFSQQIYGVVYGNVTFHVPSNVPLKEVLWKKQKDKVAELENSEFRAFSSFKNRVYLDTVSGSLTIYNLTSSDEDEYEMESPNITDTMKFFLYVLESLPSPTLTCALTNGSIEVQCMIPEHYNSHRGLIMYSWDCPMEQCKRNSTSIYFKMENDLPQKIQCTLSNPLFNTTSSIILTTCIPSSGHSRHRYALIPIPLAVITTCIVLYMNGILKCDRKPDRTNSN
The following text describes a protein:
Function:
Iron-storage protein; May alleviate iron toxicity in the presence of oxygen.
Subcellular Localization:
Cytoplasm.
Sequence:
MISEKLQKAINEQITAEMWSSNLYLAMSFYFEKEGFSGFAHWMKKQSQEEMGHAYAMADYIIKRGGTAIVDKIDVVPNGWGTPLEVFEHVYKHECHVSALVDKLVDVAAAEKDKATQDFLWGFVREQVEEEATAQGIVDKIKKAGDTGIFFVDSQLGQR
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
Subcellular Localization:
Nucleus.
Sequence:
LFEYLEHLPPQTLKSIYALPAPRGPTVAAAVVRSSALTDIARQCALRLVACGGSFKVESIVEGWIHRHGRRDAFVALRRLECMGILQPLGLATRFGEDEVLAPEFKAALTAYLATASSSPWPIITQDHIDEFSMDGGDLETYTQSSWDSVLHFLVGSDETDRGSGYGIEEPPEAMVQFLMRIGLMQVDPDFKGNDKSRAPLVITSKGYEFMLRDTNAQVWQFVLQYLNSMAHHEQKDFIRMEALSFLICLGSCRVGEGYQSSVLGSKSARALMRDFSRFGLLFVCRVAGKNSFYPTRAAVNLVASSEKAGRQASDLMGQTLAAPVPSRSHLAVVVQTNFQVVAYTKSKLHISTLGLFCDVSSFRRLPNVIFFHITRDSIRSAFRLGVTADQILRFLHVHAHPMLRSGDRPMVPSNVVDQILLWDRERHRVVMDEVCVHQCRDAAEFTAVSQYASDVDALAW
The following text describes a protein:
Function:
Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC), the main low-molecular-weight thiol compound instead of glutathione in halophilic archaea.
Sequence:
MDVGSPEAFSESGTLGVEEEFFVVDEHGVPTAGSDELVYEGEPPEPIAGRLDHELFKFVVETQTPTLNGVAEAPAAIREVRAALVAYASEHGLRIAGAGLHPGARWREHEHAEKPRYRSQLDRIQYPQHRNTTAGLHIHVGVDDPDKAVWVSNRMRWHMPVLLALSANSPYWNGFDTGLASARAKIFEGLPNTGLPTAFESYAAFQAFERRMVEHGGIEDRGELWYDVRPHSGHGTVEVRAPDAQADPAVVDAFVEYAHALVTEYAQRYDDHPDPFSVTGLRRELLDANKWRAMRDGHDASFVARETQGAVDLGTVVDRECDRLGVSGIRDVYDDVSGAQQQRRILDTHGEKRLYNHLSL
The following text describes a protein:
Function:
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Miscellaneous:
MISCELLANEOUS: Present with 2940 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MIMLRIPTRSYCSPSKLIKGVGLSPLKKSLLSKKIKEDIHPSLPVRTRFAPSPTGFLHLGSLRTALYNYLLARNTNGQFLLRLEDTDQKRLIEGAEENIYEILKWCNINYDETPIKQSERKLIYDKYVKILLSSGKAYRCFCSKERLNDLRHSAMELKPPSMASYDRCCAHLGEEEIKSKLAQGIPFTVRFKSPERYPTFTDLLHGQINLQPQVNFNDKRYDDLILVKSDKLPTYHLANVVDDHLMGITHVIRGEEWLPSTPKHIALYNAFGWACPKFIHIPLLTTVGDKKLSKRKGDMSISDLKRQGVLPEALINFCALFGWSPPRDLASKKHECFSMEELETIFNLNGLTKGNAKVDDKKLWFFNKHFLQKRILNPSTLRELVDDIMPSLESIYNTSTISREKVAKILLNCGGSLSRINDFHDEFYYFFEKPKYNDNDAVTKFLSKNESRHIAHLLKKLGQFQEGTDAQEVESMVETMYYENGFSRKVTYQAMRFALAGCHPGAKIAAMIDILGIKESNKRLSEGLQFLQREKK
The following text describes a protein:
Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Sequence:
MKPQDLKLPYFWEERSPQIANHVFYVPNYYSRYEEFVMPTWQELFANNGPICCELCSGNGDWVVEQALKDASVNWIAVEKRFDRVRKIWSKMGNYRVNNLLIVCGEAQTFFSHYVSDASFQKIVVNFPDPWPKFRHRKHRLFQDLFVQDMMRTLVVGGQLTLATDDYNYLVNAITVMLKYLSPGLKSPHYINVKDNYGGSWFENLWRSKGQEIFCTEFIKRVGI
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MKPCQKMEGNLEKEDEPKPEEEPKPEEKPEEGQEPEEEEKSEETFRERLIRSLQDFQEDIHNRHLSSDDLFRDVEELDEIRKVRNKLIVTRWKANRSHPYPYLM
The following text describes a protein:
Function:
Involved in resistance against the herbivorous insect brown planthopper (N.lugens, BPH). Member of the BPH3 (BPH resistance locus 3) cluster which contains LECRK1, LECRK2 and LECRK3.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MSCKTFLFKHLINSKFLKFHLFISETAKQLHNTKSILSRETKECMASSNLRILQALFVSLLLFIPKVFSFDCSQPKGSSLSSLEANPSWLSPNEEFAIGFQKLPNDNENHFFLAIWFNKIPETTIVWFAHTEPAPQGSTLKLTDEGKLVLHDPQGNSLWERPSTGGAKSMCASMNDSGNFMLLDGDNNPIWETFNETTDTILPGQTLNMGSNLTARYSRESYVDGRFQLHLQPDGNLVLYTVTMPTGAVRGAYWATGTMTGNSKLVFNENGYMYVTDGTRWVYNLTKNDAGSSQDFYHMARIDYDGVFRQYHCPKSKNCGLKWSVVKRFPEDICSVILTEVGSGACGYNSICVETNGEPACLCPENYSYLNEFAKNQGCRPNFELPSCRPNGWESNLGLVEFVEYNNTDWPLDDYDLQIGSGVDLQTCKQLCLDDCFCTVAIHNGNSCWKKKYPLSNGRREPNVNRTALVKVPKVNVTELYLVSQRQNNKDQSTTVLIVSILLGSSVFINIVMTLAICIAIYFSYHNKLLNISSVSSVASTNIRSYAYKELEQATGGFKQILGKGAFGTVYKGVLASHPKRFVAIKKLEKFEQEGEKEFKTEVSVIGQTHHKNLVRLLGYCDEGEHRLLVYEYMTNGSLASLLFGITRPDWNQRVQIAFGIARGLMYLHEECSTQIIHCDIKPQNILLDEFYTPRISDFGLAKLLVAEQTRVARTNIRGTVGYFAPEWFSRASITVKVDVYSFGVLLLEMICCKSSVAFGMGDQEEALMDWVYACYCKKKLDKLVENDEDARNDMKKLERLVMVAIWCVQEDASLRPSMKKVTQMLEGVVDVSVPPRPSIYCST
The following text describes a protein:
Function:
High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE), with much lower affinities for other HETE isomers (By similarity). 12-S-HETE is a eicosanoid, a 12-lipoxygenase (ALOX12) metabolite of arachidonic acid, involved in many physiologic and pathologic processes, such as cell growth, adhesion, inflammation and cancer promotion. 12-S-HETE-binding leads to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B pathways and leads to cell growth. Plays a crucial role for proliferation, survival and macropinocytosis of KRAS-dependent cancer cells by mediating the translocation of KRAS from the endoplasmic reticulum to the plasma membrane (PM) and its association with the PM (By similarity). Contributes to enhanced immune responses by inducing dendrite protrusion of small intestinal CX3CR1(+) phagocytes for the uptake of luminal antigens. Also acts as a key receptor for 12-(S)-HETE-mediated liver ischemia reperfusion injury; Proton-sensing G protein-coupled receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MERTNCSAASTVVETAVGTMLTLECVLGLMGNAVALWTFFYRLKVWKPYAVYLFNLVVADLLLATSLPFFAAFYLKGKTWKLGHMPCQVLLFLLAFSRGVGVAFLTTVALDRYLRVVHPRLRVNLLSLRAAWGISSLIWLLMVVLTPQNLLTCRTTQNSTECPSFYPTGGAKAIATCQEVLFFLQVLLPFGLISFCNSGLIRTLQKRLRESDKQPRIRRARVLVAIVLLLFGLCFLPSVLTRVLVHIFQEFKSCSVQQAIVRASDIAGSLTCLHSTLSPAIYCFSNPAFTHSYRKVLKSLRGRRKAAESPSDNLRDSYS
The following text describes a protein:
Function:
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MLKITFITGIFCLITKVSGLKVTQPDIIVASRHGKATLVCDYRTRAKVEEMRFRLLRKMGNQMKEICAFSYSTNYESVTTGDAIHCEGEPGPNNVTLHVSGMQISDTGMYICKLDIMYPPPYRTTEGNGTLIYVSDLMSECAQSMVPPESILDQKILLVVCFVLFLYCLIITAVLLCGKQRKKFNIGNYEKMLESDQGNGFSPYYIRFN
The following text describes a protein:
Function:
The glycine cleavage system catalyzes the degradation of glycine.
Sequence:
MAKQTPLYDQHVACGARMVDFHGWMMPLHYGSQIDEHHFVRQDAGMFDVSHMTIVDLHGNRTREFLRYLLANDVAKLTQPGKALYTGMLNESGGVIDDLIVYFLSEDYFRLVVNSATRDKDLAWISQHAEPYQVEVTVRDDLALIAVQGPQAQQKVATLLTTEQQQAIAGMKPFFGIQTGDLFIATTGYTGEAGYEIALPKQQVVAFWQQLLAAGVKPAGLGARDTLRLEAGMNLYGQEMDEKTSPLAANMGWTVAWQPEDRQFIGRAALERQRMKGTEQLVGLIMTEKGVLRNELPVYFFDAAGNQHVGVITSGSFSPTLGFSIALARVPAGIGEHAVVQIRNREMPVRVTKPGFVRAGKAIVL