lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probably catalyzes the hydrolysis of the 9-O-acetyl group of 9-O-acetyl-N-acetylneuraminate (Neu5,9Ac2). Is required for growth of E.coli on Neu5,9Ac2, an alternative sialic acid commonly found in mammalian host mucosal sites, in particular in the human intestine.
Subcellular Localization:
Periplasm.
Sequence:
MNAIISPDYYYVLTVAGQSNAMAYGEGLPLPDREDAPHPRIKQLARFAHTHPGGPPCHFNDIIPLTHCPHDVQDMQGYHHPLATNHQTQYGTVGQALHIARKLLPFIPDNAGILIVPCCRGGSAFTAGSEGTYSERHGASHDACRWGTDTPLYQDLVSRTRAALAKNPQNKFLGACWMQGEFDLMTSDYASHPQHFNHMVEAFRRDLKQYHSQLNNITDAPWFCGDTTWYWKENFPHSYEAIYGNYQNNVLANIIFVDFQQQGERGLTNAPDEDPDDLSTGYYGSAYRSPENWTTALRSSHFSTAARRGIISDRFVEAILQFWRER
The following text describes a protein:
Function:
May have a role in maturation, such as during flavor formation or other metabolite production specific to aging tissues.
Subcellular Localization:
Membrane.
Sequence:
MALIWTTLILALVIYMFHKLLNIKNRKKLPPGPIGIPILGHLHLIGKNAHQDLYKLAKKYGPFMYLRLGLVPTIIVSSPETVEKVLKTYDHVFASRPHNEASQYISYGQRNLIFSKYGSYWRNMRKLCTLQLLTSQKVNSYQSSRKEEVYILVKSIKQAAQDGVAVDLSAKVSSLNANLSCLMVFGKKFMDEDLDKRGFKSIVQEVAHLAVTPNLGDFFPYLGVLDLQGLTGRLKALSKFFDEFLEKIIEEHVQSKEQRETEDFVDTMMAIMQSGEAGFEFDRRHVKAILLDMLTASMDTSATSVEWILSELLRHPQVMKKLQKELEEVVGLDRMVEESDLENLKYLDMVIKEALRLHSVAPLLNHESIEDCVVDGFFVQKGSRIIVNVYAAQRDSNAWPEPDKFFPERFVESNVDLRGHDFQLLPFGSGRRSCPGMQLGIIIVRLVVAQLVHCFDWELPNGMQPSELDMSEQFGLVTYRAKHLMAVPTYRLHYN
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs (By similarity). Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree (By similarity). May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MINMDISVTPNYSYIFDFENDFIHQRTRKWMLENWTWVFYYCGIYMLVIFGGQHFMQNRPRFQLRGPLIIWNTLLAMFSIMGAARTAPELIHVLRHYGLFHSVCVPSYIEQDRVCGFWTWLFVLSKLPELGDTIFIVLRKQPLIFLHWYHHITVLIYSWFSYTEYTSSARWFIVMNYCVHSVMYSYYALKAARFNPPRFISMIITSLQLAQMIIGCAINVWANGFLKTHGTSSCHISQRNINLSIAMYSSYFVLFARFFYKAYLAPGGHKSRRMAASLAAQNVVKQSSSPQQASESSKFIGAGEDQAAYLRKAKAQ
The following text describes a protein:
Function:
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSFEDVGVGFVQHYYNFFANQRDQLAGIYRPNTLLTWQKEQVQGVDAIMARFANLGFTEAAFKQDSIDCQPSMSGGVIVIVNGEVKLRGEEHSLKFNDFFHLAQDNGQWYVSNQVFNLVGGGGL
The following text describes a protein:
Function:
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (By similarity). Preferentially binds sialic acid to the short O-linked glycans of certain mucins.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MLWPLPLFLLCAGSLAQDLEFQLVAPESVTVEEGLCVHVPCSVFYPSIKLTLGPVTGSWLRKGVSLHEDSPVATSDPRQLVQKATQGRFQLLGDPQKHDCSLFIRDAQKNDTGMYFFRVVREPFVRYSYKKSQLSLHVTSLSRTPDIIIPGTLEAGYPSNLTCSVPWACEQGTPPTFSWMSTALTSLSSRTTDSSVLTFTPQPQDHGTKLTCLVTFSGAGVTVERTIQLNVTRKSGQMRELVLVAVGEATVKLLILGLCLVFLIVMFCRRKTTKLSVHMGCENPIKRQEAITSYNHCLSPTASDAVTPGCSIHRLISRTPRCTAILRIQDPYRRTHLRNRAVSTLRFPWISWEGSLRSTQRSKCTKLCSPVKNLCPLWLPVDNSCIPLIPEWVMLLCVSLTLS
The following text describes a protein:
Function:
Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Prevents the accumulation of intracellular nicotinamide, a known inhibitor of poly(ADP-ribose) polymerases (PARP enzymes). May play a role in the regulation of seed germination potential.
Sequence:
MASSSSRTYETRKREPNPKIAALLVIDMQNHFYSMAEPILQNALTTIDICRRASIPVFFTRHNHKSPTDHGMLGEWWNGDLILDGTTDSEIIPEINRQVTGPDEIVEKSTYSAFNNTHLQEKLDKIGVKEVIVIGVMTNLCCETTAREAFVKGFRVFFSTDATATVNEELHEATLMNLAYGFAYLVDCDRLRRGLLSS
The following text describes a protein:
Function:
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.
Subcellular Localization:
Cytoplasm.
Sequence:
MLRRCCLLFFCLLLSLPVRAEESVALPLTAELRTWLAEHRELRVGVVTEAPYAQYDRRLQQYSGANVELMGWLATAMQVTLRWQGYPDQAALDDALRAGRVDIAPGLSQTPAGLRLWLFSDPYLRVSRLVVGKRDGSGSVELEQLERDTRVAVRAGSSVADYLSSTYSGLQWVSADSEREVLRAVLAGQARYAVIDEAQLSRLTREPEFAELAVVGDIGYPQLLRVATRRDWPELAMVVDQALRSLPRKSLDQLHERWLQPKYPRLGESPGFWQNLSILLGLLLAGALVAVFLQRRQQHALEARLYGARRDLELRQAAEEALRLTQFSIDNSTLGILWVNWDSRVRYANRAAEQMLGHADGQLVDRPLADFEPGLDMDRWLNLWRRARNSEEGPLSFETRCLRADGSWLPADVSLSFLRFGTSEYLVVFLSDVTERRRAREALQESEARMKGIASNVPGMVFRLERPRAGAFSDFAYISEGSEALVGYSARELIESGRGIRGLVHPDDRERYWSSQMAALDENRDWHWQGRILTRQGELRWADIKASARCFEDGRAVWDGVVWDITANKQIELELGESRAQLRELSAHLESVREEEKARIAREVHDELGQVLTVLKLETSMCELAYADAQEGLRERLGNMKKLIAQLFQLVRDVATALRPPILDAGIGSAVEWQARRFEARTQIPCLVEVPENSPQLVDAKAIGLFRILQEALTNVMRHAEAHTVQLRLLREGDELCLSVSDDGRGFDVATVGRGSSFGLVGMRERVLMMGGTLDIDSAPGEGTTLSVRIPLGVAGP
The following text describes a protein:
Function:
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
Sequence:
MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MFNILSRVCRSSSFHGFLRSSGYPRFGASFRGISMLNDLNNSANYQSKKRVGRGPASGLGKTSGRGHKGSGQRRGRRIKPGFEGGQTPITKLFPKVGHSTGHLKKPLRLGLGRVQEWIDRGRLDASKTITMKDLLDSRCCRGIKHGVELTADEPGLLKTAISIEVSKATVQAIQQIKNAGGSITTVYFSPLALRAHLHPSSFRTPPRPPLPVSKKDIRYYTNPHFAGYLANVKNIRELYYGDQRFPYEPIVKDK
The following text describes a protein:
Function:
Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTRNDTPVTQVALIGLFVTALVTAQLTASKLLLFELPVSLPVTGAALVLPGAALAYAVTFFASDCYAELYGRRDAQVMVNVGFVMNLVLLALVYSTVRAPIAPFSGVGQDAFATVLLSAGNIVAGSLLAYVVSQNWDVIAFHAIRDRTGASHLWLRNIGSTATSQIIDTVIFVTVAFWAAPVLLGVGQPRTPAQLLALIVGQYLLKLAIAVGDTPFVYAVVAAARSRGLGAPAPAAD
The following text describes a protein:
Function:
Promotes anthocyanin accumulation through interaction with PHYA, especially in response to far-red light, high light and sucrose treatment, probably by triggering A3G2XYLT/UF3GT expression. Required for gametophytes development as well as male-female gamete recognition during fertilization, possibly by regulating mitochondrial gene expression. Represses PHYA-mediated PIF3 phosphorylation.
Subcellular Localization:
[Phytochrome-interacting ankyrin-repeat protein 2]: Cytoplasm. Nucleus; [Protein ANKYRIN REPEAT 6, mitochondrial]: Mitochondrion.
Sequence:
MLQEPSAAFSLRRNSFRRRSPRSNVDDRGWNPLHIKARKGDLKSVKQLLDQGMDVNALAWGPKSKGVSALHLAAEGGHIEVMDLLLERGANIDAKTWGSCGWTPLHAAAKERKREAVKFLVENGAFLADDITDTRFNPPVHYCHGLEWAYEEMKKLNSESSSSSGGDTSSSSDN
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MKTTKAPPTDPSSSRRAQPLRQTRNNPPRSSISGSRPFGPRGSIGGGDGVPNVDQTVEIFPAITQFADAISALPKELVRHFTLLKEVDAKVFGPEEELARLVDIALNTPPPTALNYSSNSRSASTNGHHHLSSTNGSLANGNGGPAGMLMEMQGESFAPVNPAYAIYHTPNMPRRRQFQSCASYMQNMLVSLDEKNHVISTAGEALNKQLARLDQCFPHIEKEVSEEARYGSTTHWAYPENRTSKTNSGGNSRRDAPPANNPSAAAQQVAEEHAARSDARKQALLARKGAKNQHADSDFDDSQEGRKADSNKRPHGNSKARKAATTETPTGVGLGIINGNGTNGNPPKRRKVDKTTTAGPSTERVLNGVFGTNGTASKGKAGSPRSTPAPDGTKKPARARAAPNGQARKRNNTANAAMSPSLASSPVRSTFPDIKPPVRASPAPVNGGRPASARARQNSVQSVADTARRPPSSASNKPNGNAPGTPDLAVVASVTGKTIPEVKATMKEAGTNGKGEHLLEDAQPQNPEVLGGIIVGNSRESMKREETVESNGDAMQGIQSTTITTTKSGRASKPSTPAMPSFVEPVRSRSSRSIPDPVSTAKRSHKKGAGAAAQLIAQQNMELDDTTSSAQGDDEDVEIDADEPTYCYCNGVSYGEMVACDNGTCEKEWFHLECVGLRIAPKGNAKWYCDDCKEKTKNKRFNNGR
The following text describes a protein:
Function:
May play a role in plant defense. Probably has no oxalate oxidase activity even if the active site is conserved.
Miscellaneous:
MISCELLANEOUS: Is the most highly expressed of the GLP genes.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MLRTIFLLSLLFALSNASVQDFCVANLKRAETPAGYPCIRPIHVKATDFVFSGLGTPGNTTNIINAAVTPAFAAQFPGLNGLGLSTARLDLAPKGVIPMHTHPGASEVLFVLTGSITAGFVSSANAVYVQTLKPGQVMVFPQGLLHFQINAGKSSASAVVTFNSANPGLQILDFALFANSLPTELVVGTTFLDATTVKKLKGVLGGTG
The following text describes a protein:
Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.
Sequence:
METGKEEDGVSAALVDSLKAAIRDWMVDAGVGSDFQVPDVGVRRISEKVRQKLQEDSTSEWEASYTSNAAFLVASALKKRRNLDGGQLAMEVVPADLASQLAAKLSAQQLSGVVVKACKGHVNFYLSSSAKGKSSVAAIHGETKAGHGDGEAPVHRVKRTLEVRMQRSAFDRESFELYKKYQVLVHNDKQVLESSYRRFLVDSPLVPFQSASTSYGSFHQQYRIDGRLVAVGVVDILPKCLSSKYLFWDPDFAFLSLGKFSALQEIEWVKAAAEPSLQYYYLGYYIHSCPKMRYKAAYAPAELLCPLTLKWIPFDIARPLVETGAFVRLSGENKQADITSNGTEALELHETPKNLGEVPILLYSSARCILLKDLELAAPKRFIEGLKWQLLQYWQLVGEGLASRMAYAIQSKFS
The following text describes a protein:
Function:
One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular Localization:
Cellular thylakoid membrane; Single-pass membrane protein.
Sequence:
METIYLLAKLPEAYQIFDPLVDVLPVIPLFFLALAFVWQAAVGFK
The following text describes a protein:
Function:
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Subcellular Localization:
Secreted.
Domain:
A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
Sequence:
MRHLWLLLLSVSLVQTQAATTDSDKVDLSIARGHRPVDRRKEEPPSLRPAPPPISGGGYRARPAKVDAGQKKVERKPPDAGGCVHGDGDMGVLCPTGCELRQTLLNHERPIKNSIAELNSNINSVSETSSVTFQYLTLLKDMWKKKQAQVKDNENVINEYSSILEDQKLYIDETVNDNIPLNLRVLRSILEDLRSKIQKLESDISAQTEYCHTPCTVNCNIPVVSGKECEEIIRKGGETSEMYLIQPDTSSKPYRVYCDMKTENGGWTVIQNRQDGSVDFGRKWDPYKKGFGNIATNEDTKKYCGLPGEYWLGNDKISQLTRIGPTELLIEMEDWKGDKVKAHYGGFTVQTEANKYQVSVNKYKGTAGNALMEGASQLVGENRTMTIHNGMFFSTYDRDNDGWVTTDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGLYSWDMSKHGTDDGVVWMNWKGSWYSMRRMSMKIRPVFPQQ
The following text describes a protein:
Function:
Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Microsome membrane.
Sequence:
MMQPPPQTVPSGTGGPPPVGGPRNMYWSNSPYSRRANAPMTAVGGPVQPVTDPFAFGRQTPQGTALGNPSKGNSLVMQGPSQPMFSQPPGMHVPHNHAGDNSQGLYTSLSGPVSQPEVNTDSFTNVLAPVAMPGHVMNSSAEIHPTVEPGIQTSSVPSHYNPGAGENSFGGHLQCGVPLPGRPLSRQDPNGGTPAPTTSFFPQPHQQTPVQWRPVQGSPQSSIQNYSPYTEPPSQNAVPLASGSSHFFPQANMHQVPGHQQHVPFVSTSGPLVSEKSETVPSQSGNYTANNFQPENMFRQNLGVNSSWLSQEFRQNLVGSKQHLPDPTLVNPIAQGNSLENQPQHRTEAVTSHVPPELNSGTITMFFKGEEAENEENLSSEKADTAVKSDFDGFPSNSGHGGHHLPHPMQIGASAPFQASVPKGSANESSQQGLEAQQYFSQSTSNQHDKQTTKNCDIYVNDDKACTVKTCGAIGSQYENVENLECIQNQEVPPSEPPNLNPSSSNDQFRYGPLPGQSVSKHSIVSYAEGGPNLEAPDSIPHPVRSDSVSSNYSSISHRSISSSTRPQESVGTFIQQEVGKPNEEASGSFFKQIDSSPLVGETNDNNINKSYHSNLSQPPTPSPPKPTGIFQTSANSSFEPVRSHGVGVKPIEADRANVVGELRENHSKQNNSKPTVTVPAASPGNLEQPPDNMETIFTPRAHPLPLTTTDEGVNMLSHVGGTLLENVPLASEKRPSRAQGATKKCESPATTLWAQNELPNFGGNVLLAPAAPALYVPAKSSEIIQPPDEGQPCKPGSIPLHSSPDGNVSSENLENPPKMGEEEALQSQASSGYASLLSSPPTESLQNQPILIAQPNQSYNLTQPINFSVSLSNQLSHNENNHSCKDSGVGDKSAPSSQPLCAGVPRESVPLSGTQAASPVNSPLPTTNHSHSNFSQGPGTTSEMVPNQSPNLLVQPPSHQMPLNLVPECQKNQNSESFPSEYTTKPVVNLSASPGTNLPSGNTGVMLVPPVNNTLIPHVNKTNLTNYQEETSGALDFTLNRTLENHSTDNSVRIHNTSHSSGPTFSQQAITNHTSQSGPELHDKEHFYQQVTKDVQQQIVLDKSQPGALPPQQQGSSAAQVPKTASDSSNSGIQPDSFPSGNSPQLPSQGKVDQPQLSQSSSVSTTSVHSGQPASQQEQQWPPSQTPQNAFGPPSNLSTYYYYRHLYDTYQPQYPPPYPSDPRTASLYYPEDAYGPYDPRYRHYDNSAAYAENYRYAEPDRPSSRASHCSDRPSSRQGYPEGYYTSKGGWSSHSDYYANYYSGQYDYGDANRWERYQYDPRFRDPRSYDRRYWYDTEHDHYRKEAYPYSDRPEKYDDHWRYDPRFTGSFDDEPEPHRDAYDDDRRSIHSEHSAHSLHSTHSLQSRQSSFSSRSHQSQVYRNNDVTANSYERPAPPGSLHGEYSYGVYGNNFNGAQGFTDYGYSAETGWPTSEQVPSRPTTPEKFSVPHVCARFGPGGHLIKVLPNLPSEGQPALVEIHSMETMLQHTSDQEEMRSFPGPLAKDDTHKVDVINFAQNKATECLRNENLIDKESASLLWDFIVLLCRQNGTVVGTDIAELLLRDHKTVWLPGKSPNEANLIDFTNEAVEQVEEEESGEAQLSFLTDSLMTTIDSLEKETERFRELLLYGRKKDALESAMKHGLWGHALLLASKMDSRTHARVMTRFANSLPINDPLQTVYQLMSGRMPAASTCCGDEKWGDWRPHLAMVLSNLNNNMDVESRTIATMGDTLASKGLLDAAHFCYLMAQIGFGVYTKKTTKLVLIGSNHSLPFLKFATNEAIHRTEAYEYAQSLGTQPCFLPNFQVFKFIYACRLAEMGLAAQAFHYCEVISKTILKQPRQYSPVLINQLIQIASQLRLFDPQIKEKPEQESFIEPTWLIQLQQLKRQIEEGDVIWNQDRATPHQYPSTPSSELEQYDGTGHGQEIGPGTDNPLLASLLPNTEQSNQSIRLMPSAPQTILENSGSMPASFQSEKPDNVPFYPVPPGSVGHVPVYGPPLSVPGFSDQYGPEHGAVYPGSNVSPGGQPLQVTDQLPEDSRIQDTGRVPQESSIKNSLSEQREEDFGGKFANLASGRRSRTTSQSSAHMEYSRKCPNTESYKGRERSNSAGQQPSPSPTFASEVKRPTKEVKKESKEPKKSGESWFSRWIHGKKKTEAHLPDDTNKSIVWDGKKQRWVNLDEPEEENKPPPPPPTSFPKLPQVAAPSGPGGPPNASVNMFSRKAAGTRARYVDVLNPSGTKQSGPVPAPSDLFAPLAPLPIPSNLFVPNSEEQPLENSGLEEQLPDAYQPDLEPTTEPQLLNSATLPPGSELAASNMDGHQSGEPPSLPPSGGPPVGTVPFYNPSQFAQPPAVTGSSRLGRIGQRKYPTLK
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MSKKLASPLSFLPLYNLLSAVGWSYLLYLVISLYPKVGQPAFFYQTKNVATLVQCGAIIEIINSFLGVVRSPLLTTVAQVSSRLLVVLGIFQLLPNTSGVQSVVYISLLLAWSITEIVRYLYYFFMLVFKNGAPKILILLRYNLFWILYPTGVASELRIIYCALNAAESQYSLLYKRILIAAMLAYIPGFPMLFLHMVAQRKKVMKSLRSSFGKKLI
The following text describes a protein:
Function:
Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy. May play a role in dendrite postsynaptic membrane trafficking.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus membrane. Postsynaptic cell membrane. Vesicle.
Sequence:
MTSTEVRPTPSTELRTRTTTEVRPTKRTSTAFPPSLSAGPTMAARSGERRLLLQRLPARKDGAAWARAGNPVGKGLPSGAGAGRGVASRVSSGGSGSLSLLRGVKGPRLAMGIFSVFVVNKAGGLVYQLEHYAPRAETEKTFSFPLELVLRPHDERLLVAFGQRDGIRVGHAVLAINGAEVSGRFTADGKDVLEYLANPAHYPVSIRFGRPRLSSNEKLMLASMFHSLFAIGSQLSPEPGSSGIEMLETDTFKLHCFQTLTGIKFVVLADPRQSGIDALLRKIYEIYSDFALKNPFYSLEMPIRCELFDQNLKLALEVAEKAGPFGPGL
The following text describes a protein:
Function:
Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification. Moreover, is involved in the metabolism of aggrecan (By similarity).
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MMMVRRGLLAWISRVVVLLVLLCCAISVLYMLACTPKGDEEQLALPRANSPTGKEGYQAVLQEWEEQHRNYVSSLKRQIAQLKEELQERSEQLRNGQYQASDAAGLGLDRSPPEKTQADLLAFLHSQVDKAEVNAGVKLATEYAAVPFDSFTLQKVYQLETGLTRHPEEKPVRKDKRDELVEAIESALETLNSPAENSPNHRPYTASDFIEGIYRTERDKGTLYELTFKGDHKHEFKRLILFRPFGPIMKVKNEKLNMANTLINVIVPLAKRVDKFRQFMQNFREMCIEQDGRVHLTVVYFGKEEINEVKGILENTSKAANFRNFTFIQLNGEFSRGKGLDVGARFWKGSNVLLFFCDVDIYFTSEFLNTCRLNTQPGKKVFYPVLFSQYNPGIIYGHHDAVPPLEQQLVIKKETGFWRDFGFGMTCQYRSDFINIGGFDLDIKGWGGEDVHLYRKYLHSNLIVVRTPVRGLFHLWHEKRCMDELTPEQYKMCMQSKAMNEASHGQLGMLVFRHEIEAHLRKQKQKTSSKKT
The following text describes a protein:
Function:
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
MEQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQRFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILNDESYGDPTNIQGKYQKHQSFEAEVQTKSRVMSELEKTREERFTMGHSAHEETKAHIEELRRLWDLLLELTLEKGALLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLQKKFEDFQVDLVAKEGRVDDVNQYANECAEEKHPELPLIQSKQEEVNAAWERLRGLALQRQKALSSAADLQRFKRDMTDAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSNWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMKEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSAKETGEDLLDANHEASDEVREKMEILASNWDALLELWDQRHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHDDFEEAFTAQEEKITTVDKTATKLIGDNHYDSENIAAIRDGLLARRDALRGRATTRRRLLEDSLLLQQLYQDSDDLKNWINKKKKLADDEDYKDTQNLKSRVQKQQVFEKELADNEIVLENIQKTGQEMIDSGHYASDNVTTRLSEVASLWKELLEATKQKGTQLDEANQRLQFENNAEDLQRWLEEVEWQVASEDYGKGLADVQNRLRKHGLLESAVAARQDQVNILTELAAYFEKIGHPDSKDIQARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHKVILENIASHEPRIQVITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALQNQAEACQQQQAAPVEGAAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEADDHQGFVPAVYVKRLAHDEFPMLPQRRREEPGNIAQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLKTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNARWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADAGSDLFSVQALQRQHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFGAELIDSEHRASPEIEKKLQAVRLERDDLEKAWEQRKKILDQCLELQMFQGNCDQAENWMVARENALRSDDKDSLNSLEALKKKQDDLHKAITAQEGKITDLQHFAERLIADEHYAKEEIATRLQRVLDRWKALNAQLIAEQTKLGDQADLKQFYRDLEELEEWISEMLPTACDESYKDPTNIQRKYLKHQAFANEVYGRADQVDATIDLGRSLIERSTCDCDEEAMKEQLEQLKEHWDYLLEKTTDKGQKLNEASRQQRFNTSIQDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLETEMLAREDALKDLNTLAEDLLSSGTFNVDQITEKKDSVNKRFLNVQDLAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLLRVSSQDYGRDLQGVQNLLKKHRRLEGELVAHEPAIQNVLDMAEKLKDKAAVGEEEIQLRLAQFVEHWEKLKELAKARGLQLEESLEYLQFMQNAEEEEAWINEKNAMAVRGDSGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLKDDYDFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDQLIAAQHSQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFMEFAHKASAFNNWCEKAEENLSEPVHCVSLNEIRQLQKDHEDFLASLAGAQGDFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASAFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIEDLGDNMEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDTIGVSEETLKEFSTIYKHFDENLTGHLTHKEFLSCLRGLNYYLPMVEEDEHEPEFKKFLDAVDPGRKGYVSLEDYTAFLIHKESENIKSSNEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQYMDPQGRSHLSGYDYAGFTNSYFGNS