lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.
Sequence:
MFEVFIIKIESPDCFWGSIKGGGNFVDNEMAYKKLQFEMNQFYNLTHRGLDEVKPSVLKEGQVCVVYSQEENSWCRAIVESIISCTDNYLAECFLVDYAKNIPVKAEKICCALESFMRLPYRAQKFRLYHIKPVTLRVNYYTNNAEIVPATKWNIAAIRYFQDLLDAASQVEAKLCAVEDDTFAVYLYVTKRGEKVCVNDDLVAKNFASSEKNEERSIIMEEQNQEILGLESVSVSEISPAHILSPTSLDIKEPKAVEMCECGRLSVDNKRDLKMGLKPILKIWKKFVGPNHVQSYSWPAIARGYDSVVICPENDPLIYLLPIITFLQSRNCYLSLPARNGPVALIICTRQRKAELVFEFVEKYTHCSRPLHPLLLSVGMNKEEIKSVRIPRGCELIVTTPYSLLRLLECHSLMFLRLCHLVLDEAEALFSEANDQVFNILEHYKRSLNDEVKEYVPQQIVAIGSRWTKKLEYLTKEFMNDPYVVITSLEEAAIYGNIQQVVQVSLECNRISILLQTLDFTPHNAQKTLIFTSSVEETDNICKVSPLAKEQPKAKSILLLTENSAWHTVGVLDYLKRTEANIPPELHDFTSGVLDAKENCKSGKPFCRYLKVYGFCKDKKRCPDRHRISLQVDFPKGERNSTQPTAGNVTILPLFIVDATNYFGRIVDKTKDQYTALEKEMHQYYKKSSNCISVSLVEKLALYGVHEKNYIHRVQVLQIAPKEGKCVFYSIHVKYIDEGRTGQVQNYQLLSLPEHFQVLPPQAVEFIVCRVKPIDNEAEWNPKVNRYINHKIKGQLHEAKIVHTLNNTIWVDPVVRVTKLPDLKTYINEYNIRSEILATGFGVDNPEHICELQRLFREAEIAFEKKDMPQQRTDCFTLLQQTAIGDINPQKSLNFRQDACSLQRPKPGQLCLYCRKHLRIGPRSIKWFEKEDVVVLKIKVQNITNHDCKFFTQRIIGSAEGKFYLADLELQENIVEEKSRCVLRGNEVVVSLAKEKKGSWCRLLKQKNPHVSFDFDYLEDDSEESGFPISVFLHAFVVVAVAVIFPTTPPSGNSCDSISAYILFVGSWIWFDLVP
The following text describes a protein:
Function:
Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation. Promotes as well axonal outgrowth.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
MRKFNIRKVLDGLTAGSSSASQQQQQQQHPAGTREPEIQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYVIMWNKAIELLFNISDNPMDEGKVEFKKYIYLLNAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPMQTITPHGKQLKDGKKPEPCKPILKVEFKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFAGCPGDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGVQISNKCFFLVTLQVLYKLKTSKVFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVITEVIPMLEVRLLYEINDVESPEGEQAPPLPTPVGGATPQPIPPQSHPSTSSSSSDGLRDNVPCLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVFGNCNGIAMVDYLQKAVLLNLGTIELYGSNDPYRREPRSPRKSRQPSGGMLIVTSCMYGLSSLYSESVKKLQSSLSGLCDISEGTVVPEDRCKSPTSGSSSPHNSDDEQKMNNFIEKVKTKSRKFSKMVASDIDIKDNSFSRSRSSSVTSIDKESREAISALHFCETFTRKADSSPSPCLWVGTTLGTVLVIALNLPPGGEQRLLQPVIVSPSGTILRLKGAILRMAFLDTTGCLVPPAYESWREHNVPEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVISLPTQNCAYKQNITETSFVLRGDIVALSNSICLACFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVEAPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAASGVVGELARARLALDERGQKLGDLEERTAAMLSSADSFSKHAHEVCLSNKYLNKIA
The following text describes a protein:
Function:
Functions as the light chain for myosin-B. Binds calcium with submicromolar affinity and may sense physiological calcium changes.
Sequence:
MSDEKTQLIEAFYNFDGDYDGFVSVEEFRGIIRDGLPMTEAEITEFFEAADPNNTGFIDYKAFAAMLYSVDES
The following text describes a protein:
Function:
DNA glycosylase involved in the repair of interstrand DNA cross-links (ICLs), which are highly toxic DNA lesions that covalently tether the opposing strands of DNA, thereby inhibiting essential cellular processes such as DNA replication and transcription. Acts by unhooking both sides of the ICLs, forming abasic (AP) sites on both strands. Unhooks ICLs derived from various cross-linking agents, including azinomycin B (AZB) and mechlorethamine, also known as nitrogen mustard (NM), protecting cells from the toxicity of these cross-linking agents. In vitro, also acts on monoadducts and can catalyze the excision of N7-methylguanine (7mGua) from an oligonucleotide containing N7-methyldeoxyguanosine (d7mG). Shows no unhooking activity toward FaPy-ICLs.
Sequence:
MSLPHLSLADARNLHLAAQGLLNKPRRRASLEDIPATISRMSLLQIDTINIVARSPYLVLFSRLGNYPAQWLDESLARGELMEYWAHEACFMPRSDFRLIRHRMLAPEKMGWKYKDAWMQEHEAEIAQLIQHIHDKGPVRSADFEHPRKGASGWWEWKPHKRHLEGLFTAGKVMVIERRNFQRVYDLTHRVMPDWDDERDLVSQTEAEIIMLDNSARSLGIFREQWLADYYRLKRPALAAWREARAEQQQIIAVHVEKLGNLWLHDDLLPLLERALAGKLTATHSAVLSPFDPVVWDRKRAEQLFDFSYRLECYTPAPKRQYGYFVLPLLHRGQLVGRMDAKMHRQTGILEVISLWLQEGIKPTTTLQKGLRQAITDFANWQQATRVTLGCCPQGLFTDCRTGWEIDPVA
The following text describes a protein:
Function:
Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.
Sequence:
MDDDDDSCLLDLIGDPQALNYFLHGPSSKSGSDDVTNAGYSAANSNSIFANSTNADPKSALKGVSDQLGEGPSDGLPLASSLQFLEDELESSPLPDLSEDQPFDILQKSLQEANITEQTLAEEAYLDASIGSSQQFAQAQLHPSSSASFTQASNVSNYSGQTLQPIGVTHVPVGASFASNTVGVQHGFMQHVGISVPSQHLPNSSQISGSGQIQLIGSFGNQPSMMTINNLDGSQIILKGSGQQAPSNVSGGLLVHRQTPNGNSLFGNSTSSPVAQPVTVPFNSTNFQASLPVHNIIIQRGLAPNSNKVPINIQPKPVQMGQQSAYNVNNLGIQQHHAQQGISFAPTSSPQGSVVGPHMSVNIVNQQNTRKPVTSQAVSGTGGSIVIHSPMGQPHTPQSQFLIPTSLSVSSNSVHHVQAINGQLLQTQPSQLISGQVASEHVMLNRNSSNMLRTNQPYSGQMLNNQNTAVQLVSGQTFATSGSPVIVNHASPQIVGGQMPLQQASPTVLHLSPGQSSVSQGRPGFATMPAVSGMAGPARFPAVSSASTAHPTLGPTVQSGAPGSNFTGDQLTQANRTPAPVSVSHRLPVSASKSPSTLSNTPGTQQQFFCQAQKKCLNQTSPIPTSKTTDGLRPSQIPGLLSTALPGQDSGSKIMPATLGATQAQPESSVGSSPSQTAVQVDSHPGQKRPAAKQLTKGAFILQQLQRDQAHAVTPDKSQFRSLNDTVQRLLSYHVCQGSMPTEEDLRQVDNEFEEVATQLLKRTQAMLNKYRFLLLEDAMRINPSAEMVMIDRMFNQEERASLSRDKRLALVDPEGFQADFCCSFKLDEAVPETPLDRSDQHRSKTSSLHQVPRAQSRDRAKPGMAEATNHDQFHLVPNHIVVSAEGNISKKSEGHSRTLKFDRGVLGQYRGPPEDKGGRRDPAKVSRCSPGPEGHRKSLPRPDHGSESKLPGVLASSHMEMPCLDSFQDKALRNSPKNEVLHTDIMKGSGEPQPDLQLTKSLEKTFKNILELKNSGRPPSDPTASGAADLDFPSFSPMASQENCLEKFIPDHSEGVVETDSILEAAVNSILEC
The following text describes a protein:
Function:
Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain.
Subcellular Localization:
Cytoplasm. Mitochondrion matrix. Note=Concentrated in cytoplasmic granular foci.
Sequence:
MALSLGWKAHRNHCGLLLQALRSSGLLLFPCGQCPWRGAGSFLDPEIKAFLEENTEVTSSGSLTPEIQLRLLTPRCKFWWERADLWPHSDPYWAIYWPGGQALSRYLLDNPDVVRGKSVLDLGSGCGATAIAAKMSGASRILANDIDPIAGMAITLNCELNRLNPFPILIQNILNLEQDKWDLVVLGDMFYDEDLADSLHQWLKKCFWTYRTRVLIGDPGRPQFSGHSIQHHLHKVVEYSLLESTRQENSGLTTSTVWGFQP
The following text describes a protein:
Function:
Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase.
Subcellular Localization:
Nucleus.
Sequence:
MQLRAAQHLIAEELQMASSDDEDEKFLYGSEDEADGPRGQQKRKLIPQGTAQIQEPDTKRARGADDGDVDMLDDDDEEEDDDEDEDDEDSDSDVEIIIGTGADSSKLDSKALTTPSTAATATSAAESAIAPVSEQSAPVAAVQSGDSGAAMDKAVGALDINAVGEYEGTPITDIDPEVLKEKPWRQPGANLSDYFNYGFTEETWMEYLHKQEKLRKEYNPRKILMGLLALQQQGKLGDGGAGDGVMLSAGGMAHNDIKSPNKNNGSLPQPPAFPMGMPPMFGGFPPFPFPGMIPPNLGAASGNNGSGNHQNMGTSSGNGNNGK
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSSKIIKENKRLVLDLYKRCLYSAKRCPKYQNQMMMESYIKLKFRSNKEIHQKDFETIENLLKQGEEELKSMNDFHELRAKSKSGQDHESILNDCFDDDFNYIGSTPTVKK
The following text describes a protein:
Function:
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein. Note=Localizes to the transition zone of primary cilia.
Sequence:
MALLTPLPGSVRHGLARISGSLFIQNKTRDCGEQHAYQSGHDLLSSLPLQMMLYFNAFFFPFWIISEIITMELKFGRLSGYYQILLTTSLVILTLVESLRLYIGYVGNLHEKVPELAGFLILTLLIQLPLLLFLLTDNRNLLLPLDLAVHMIYLMFINAEIVISFLVLKTMTRQFALEYYLQQSEILVSKHVPVNRTLLRFQNTTTSIAEQYGSDALMY
The following text describes a protein:
Function:
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
Sequence:
MKDTLFNESLNKRFCFDEKVAHVFDDMLERSIPYYHEMLNLGAYFIAQNLKENIYPKSLPKPLIYDLGCSTGNFFIALNRQIQQEIELVGIDNSMPMLKKAQEKLKDFNNARFECMDFLEVEFKEASAFSLLFVLQFVRPMQREVLLKKIYNSLALNGVLLVGEKIMSEDRILDKQMIELYYLYKQNQGYSHNEIAFKREALENVLVPYSLKENVALLESVGFKHVEALFKWVNFTLLVARKT
The following text describes a protein:
Function:
Displays specific enterobactin (ENB) esterase activity required for intracellular release of iron. Enterobactin is a xenosiderophore that is selectively produced by Gram-negative Enterobacteriaceae. The affinity for enterobactin is quite high, potentially due to the low natural abundance of this xenosiderophore in fungal habitats. Does not hydrolyze triacetylfusarinine C (TAFC).
Domain:
Contains a proline-rich insertion between residues 112 and 122 that forms a kinked, partly disordered turn that decreases the diameter of the active site, making it too narrow for the extended, flat TAFC, while the compact, cylindric enterobactin is still able to enter.
Sequence:
MTHWAFSPIQPGAARNMAAWQIAGKKDGPYQIDVSWPLTWSESGDASGKSANAVYLVDGNALFLTATETLRRRESHRPSETGTVVIAIGYPITDSVFSPRRSYDLTPPCDHYIPPEGPDGSPKPEAHGGADEFLTFIAEIVRPFVELKVFPRVSFGRTALFGHSYGGLFALHALFTKPSSFDVYLAASPSIWWNNRSILTEARRFISGAALFSSAHPVLRLSFGSREQYPVRQRVESDEMFKRRQRAAEQRRMNDNCEELYSELLASGRLCKLEVKEYLDEDHGSVIGPALSGGIMFLSNLSA
The following text describes a protein:
Function:
As accessory component of the DNA polymerase epsilon complex participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair.
Miscellaneous:
MISCELLANEOUS: Present with 3110 +/- 251 molecules/cell in log phase SD medium; MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFGSGNVLPVKIQPPLLRPLAYRVLSRKYGLSIKSDGLSALAEFVGTNIGANWRQGPATIKFLEQFAAVWKQQERGLFIDQSGVKEVIQEMKEREKVEWSHEHPIQHEENILGRTDDDENNSDDEMPIAADSSLQNVSLSSPMRQPTERDEYKQPFKPESSKALDWRDYFKVINASQQQRFSYNPHKMQFIFVPNKKQNGLGGIAGFLPDIEDKVQMFLTRYYLTNDRVMRNENFQNSDMFNPLSSMVSLQNELSNTNRQQQSSSMSITPIKNLLGRDAQNFLLLGLLNKNFKGNWSLEDPSGSVEIDISQTIPTQGHYYVPGCMVLVEGIYYSVGNKFHVTSMTLPPGERREITLETIGNLDLLGIHGISNNNFIARLDKDLKIRLHLLEKELTDHKFVILGANLFLDDLKIMTALSKILQKLNDDPPTLLIWQGSFTSVPVFASMSSRNISSSTQFKNNFDALATLLSRFDNLTENTTMIFIPGPNDLWGSMVSLGASGTLPQDPIPSAFTKKINKVCKNVVWSSNPTRIAYLSQEIVIFRDDLSGRFKRHRLEFPFNESEDVYTENDNMMSKDTDIVPIDELVKEPDQLPQKVQETRKLVKTILDQGHLSPFLDSLRPISWDLDHTLTLCPIPSTMVLCDTTSAQFDLTYNGCKVINPGSFIHNRRARYMEYVPSSKKTIQEEIYI
The following text describes a protein:
Function:
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Subcellular Localization:
Cytoplasm.
Sequence:
MSYITKQDKVIAEAIEREFQRQNSNIELIASENFVSEAVMEAQGSVLTNKYAEGYPGRRYYGGCEFVDVTESIAIDRAKALFGAEHVNVQPHSGSQANMAVYLVALEMGDTVLGMNLSHGGHLTHGAPVNFSGKFYNFVEYGVDKDTERINYDEVRKLALEHKPKLIVAGASAYSRTIDFKKFKEIADEVNAKLMVDMAHIAGLVAAGLHPNPVEYADFVTTTTHKTLRGPRGGMILCKEEYKKDIDKTIFPGIQGGPLEHVIAAKAVAFGEALENNFKTYQQQVVKNAKVLAEALINEGFRIVSGGTDNHLVAVDVKGSIGLTGKEAEETLDSVGITCNKNTIPFDQEKPFVTSGIRLGTPAATTRGFDEKAFEEVAKIISLALKNSKDEEKLQQAKERVAKLTAEYPLYQ
The following text describes a protein:
Function:
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Note=May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons.
Sequence:
MVLYTTPFPNSCLSALHAVSWALIFPCYWLVDRLLASFIPTTYEKRQRADDPCCLQLFCTVLFTPVYLALLVAALPFAFLGFIFWSPLQSARRPYSYSRLEDKNPAGGAALLSEWKGTGAGKSFCFATANVCLLPDSLARLNNVFNTQARAKEIGQRIRNGAARPQIKIYIDSPTNTSISAASFSSLVSPQGGDGSRAVPGSIKRTASVEYKGDGGRHPSDEAANGPASGEQADGSLEDSCIVRIGGEEGGRPQEADDPAAGSQARNGAGGTPKGQTPNHNQRDGDSGSLGSPSASRESLVKARAGQDSGGSGEPGANSKLLYKTSVVKKAAARRRRHPDEAFDHEVSAFFPANLDFLCLQEVFDKRAAAKLKEQLHGYFEYILYDVGVYGCHGCCNFKCLNSGLFFASRYPVMDVAYHCYPNGCSFDALASKGALFLKVQVGSTPQDQRIVGYIACTHLHAPPEDSAVRCEQLDLLQDWLADFRKSTSSTSTANPEELVVFDVICGDLNFDNCSSDDKLEQQHSLFTRYKDPCRLGPGEEKPWAIGTLLDTNGLYDEDVCTPDNLQKVLESEEGRREYLAFPTSKSPGAGQKGRKDLLKGNGRRIDYMLHAEEGLCPDWKAEVEEFSFITQLSGLTDHLPVAMRLMVSAGEEEA
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes; Regulates also the sphingolipid metabolism.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MICIKCGSSNSNLYTVYNKNNIRLNECNRCNKICDEYVEKNRFIIFLNILFLKPEIYRHIVFNRIKYHDKFINNFFLKMIIIFLIINAYLHPNFERENIKNTGILSNIFFMENNFEEYIQGTDKYKNDCSSYTLFIYKYDDKHKLYGLYNIFNNYNMSNLVNIHKNKYLTCIVNNKFSDYNLCIVNRQFKAEDDYDKELINIFINNNGKYIKKYNTTVSTNSKLHKDHINKNNINNDNNNNNINNNINNDNNNNNINNNINNDNIYTSYKDNRNNKNIWYETNFFKKISGSQILYYILHFINKSISKIKYILKYDSIFYFKKNNTLLKNNIINLKNPEEYNDLFQIINILVYYNIHNYKIVLEPKEKENLNIDFIFKFIKNIFFYNQFIQKKNYIQSQTNTYMNDPKKKNDLQNNCVHQSEISTFNNFTSTNNHIKNQDNNKKMCHNNNDNLHNIYPFDDLCNEFLKNINSTLNKKMAEITKKQNKIQDTFQIKQISMYSKLLFSELDNEKYILKICNSTFSFKKFKTVIISYITYFLFLCIFTYFFKLYQQHKYNIKITMVKYNYLFMLFVLSNYPLVIYFILKIFNYNYINIYLNIYTIVCNIIAYHIFISTDQNYICYSIFSVLTSYLLKYLVMLKIINYI
The following text describes a protein:
Function:
Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKILLHLTEQASNHHVVAVLGTWGSTGQKGFLLHPSSSIICSNVLKASAQVYDNVVELRFIISSIPVFNFAAAVAAGRLYNNRKKSFWKFLYIAMLGLILGSLACTAVFFMASYENYPSGYALKALHRIGLHMIICTHDVLENGRNLGYICNFSRVPAVFGNSHPLYFPAYNVELNLCLGGVTKNSDELRVHIDTFSAMNGISRFCEYNYPWSCNLTSKIAPLGIDCKVLVIGNRSDIFSFVRLRHYGHFPDVERSRQRRVQHVLTVRENPMSRGSHVGSILEAKLPCLLPPCVDLLFMISSSSLCQSLRRCRCTALKLFPSMLDKFQCHVMEDNFDSIATVALAPQF
The following text describes a protein:
Function:
May be involved in mitochondrial iron or copper homeostatis.
Miscellaneous:
MISCELLANEOUS: Present with 2160 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MLINHLSKIRTVRHFSNIKPVLSKEVSRRVIVAPASHFKTSSPNVKSNIPIHEYKQLPEDSNYIEKHYKELQVFLNEFLIKKLNKTYADFEGDPDELVFQLEKFIELEVTPRYTNHSAPDGCEERFKSIGDRIVVDRYLDFVKDVRLTLLLNGGHSFIFDVMLQAKEVFDKMQKE
The following text describes a protein:
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. May methylate the ribose of the second nucleotide of a m(7)GpppG-capped mRNA (cap0) to produce m(7)GpppRmpNm (cap2) (By similarity). Regulates expression of tracheal genes required for pathfinding on the segmental nerve.
Subcellular Localization:
Nucleus.
Sequence:
MSFRSSPQGKPHPMTDYQSIRPSEVEQLFEKKFHYQKPKGNKSWQLPPPDQALFSEFYQFEALQGLREQLNAVKSKLNDYGVQEWSAHTNRRDPSGEVSWRLKNDTKAEFVTVAWCKLFECLHRYPLVTKPAVNSMHLCEAPGAFIASLNHYLHSKYEKDEIKWRWRSTTLNPYYEGNAINQMISDDRFIVHTLDNWFFHKDLTGNLLDVANIDHLVERCEVEFQGQVDLVTADGSIDCAAQPDCQEEIVVRLFFAEVLSALRILSSGGNFLVKMFTLFEACSVSLLYTLNCIFEEVHIFKPATSKRGNSEVYVICLNYNKDHPDLPRLLEEIKSKLAQPNDTLVMPLFAKFQIPHDFLMQHEIACRMYMKLQTDAIEGSIYAYESNDRHYLRHLHHLRSLVANTYYSLYKVKPLEDSLCIVDKEATSKALGFQVPVYGGSYTERESLKHGDLLKQIYCLRREFNQLEKCLNNRTPYSYVKNRTAPLNLHISRGAPVQSLQSSMFASEPILILRLRILDTFELDPVWQSAPKCQLESKTLCYLPPTEDEAFHTAQQRFFIDLLEEVKKLKPDSIVFHKFLFLTHYAASLLLFLIESVYQDCCFNSNQAQTLTLSKLKDTANSALEQVLELLKDEQAGAIHSLLDIKELQKNQFSKALIQHNNSIVMTCFRSMLGEESFPMPVAPTSNSDVGSIQESAAVF
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
METSAAAGGAHLIYVSSDDEEDETRVLLAESYSAEEIQIQQAILLSLDPSSDADAAHSSASSSRPSGAASTSDEPSSLPDRKGKRKLSSEEDGPIESTRKKRRKRGRFKCSVCMEKLQVSEQFTVSFCAHAFCNSCIGRYVAAKISENVAVIGCPDPGCEEGFVEMDTCRDIIPPELFDRWSVSLCELALGEKKYYCPFKDCSALLINDNDGAEKKIRETECPHCHRMFCARCRVPWHDGIKCKEFRKLGDDEKGEEDLMFKKLAGKKKWQRCPNCKMFVSRIDGCLQIKCR
The following text describes a protein:
Function:
Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands, such as CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MWVRQVPWSFTWAVLQLSWQSGWLLEVPNGPWRSLTFYPAWLTVSEGANATFTCSLSNWSEDLMLNWNRLSPSNQTEKQAAFCNGLSQPVQDARFQIIQLPNRHDFHMNILDTRRNDSGIYLCGAISLHPKAKIEESPGAELVVTERILETSTRYPSPSPKPEGRFQGMVIGIMSALVGIPVLLLLAWALAVFCSTSMSEARGAGSKDDTLKEEPSAAPVPSVAYEELDFQGREKTPELPTACVHTEYATIVFTEGLGASAMGRRGSADGLQGPRPPRHEDGHCSWPL
The following text describes a protein:
Function:
Involved in male-mediated self-incompatibility.
Subcellular Localization:
Secreted.
Sequence:
MRCVVLFMVSCLLIVLLINHFEEVEAQKWKECNLRDIFPGKCEHDANAKLRCKEDIAKNFRPSRPFECDCQTFDQGRICYCKKCLV
The following text describes a protein:
Function:
Component of the intraflagellar transport complex B (IFT-B) involved in flagellar assembly (Probable).
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body. Note=Localizes to the cytoplasmic and membrane-bound portions of each of the eight axonemes, localizing particularly at the flagellar pores and at the distal flagellar tips. Localizes to the basal bodies.
Sequence:
MYGISSFYCRDPPNLTCLTWIGIDLAVAASQTDRCLYEIIVPPSLGQVRVSRISDPIPSTIISMTALPPGNGSSASSSTSGPAVMANTASSYQITKGSGSSSTSASQATIVAGCANGTLIFIQADVLGLGCTSQRVSVRRQKSISVSSYVGGEDAIHPVTSLCMMQPRGSSLLVGLETGTVLLLTMMGGLYQFRQILKSNLNAPVHAINSIDRNRAAIAYGGSVTVINITKNNSTELSYKLQSDGDAITALANTGRVLVLGCEHRGAIVLDLLSGLEISVIPPPPYDAVVSVSSQPVASNGFIIATRRGVVIGCRENGTVRSCATLEYDSAHLPVSKIAADGAPATLLSPLADSSMTNVDENLGSSVGGIRDLAFAPYGGSFLCLCLNGLAVGYLAPQRLSSGYITIEVTGLTTVMITDARLQVSEVYTAPEPVISLFLSRFAHTLRLGATTASSVIVWTPPTMAKISSFSLEGGMPLVTKIQWITEPVRSTSYGDMIRPSTVQNQPSTQGLPNRQQQELDFDNLLEKPGDTLQQTESRPLLKSFSQKKLEHDKASNPPIKTAAYVRNPPRYIVLGDSYHLVVDISGEANIVSATTLALVTSIYISSLDSDRQIAIIDSALAYVEGGTTLRIIDPRSGNFILRGVIHHKAVLDLTIGISSQQHIRNASETSAKEGTQGNAVSDFALGSVFSNLTGHQAGKPVDATASTSSLKQTEMSSNDASSYVLALLDTSNSLYVGRLTTSPQAYAKLGNSMSTAILQQSKFLDSIPYSIQFIAQTDLLCMLISESQSLPQALSQIGETVGSDCKLRLVVDACPVRTSIITEDPVFVTPTTIDYSSVQRSNAAVSIFEEDPSRILAAYRMLSRSNIHTIHRITPMVLKNDGLMSNAITMSHAVLGLAGDSSQMVVAVPEFSVLLNYLAKSGNTQRALRLCRFLDQKPLWAQMATYCIEANNIQHLQSALSGLGMVAKASYCHSISSHNEVNAGAVKLAIGDPEGANILSSQGKIGAAILAACDLWNFSKALELCRGNKKYMPLLVYLRTKYHNNLGMSNCNNEEPWLSLSRQYGNVSEDEIHRLMKG
The following text describes a protein:
Function:
Catalyzes its autophosphorylation, which is needed for enzymatic activity and phosphorylates myosin II heavy chain at a threonine in the C-terminal tail region. This phosphorylation is critical in regulating the assembly and disassembly of myosin II filament. Participates in control of myosin localization.
Sequence:
MIFKVWFSYEDEEVELSELTNDTTVSAIRKILHEGKIFRFPYGTSQTDLQIGKMLPSGSGGGATADSKFEKFKARNTLADIQYKVGDTLYVRVKKSKPTNDSLLPTLNIAFLDGSERAIKWEYDPYTTTAQWTCTATLVKVEPVPFAEGAFRKAYHTLDLSKSGASGRYVSKIGKKPTPRPSYFEDVKMQMIAKKWADKYNSFKPPKKIEFLQSCVLEFVDRTSSDLICGAEPYVEGQYRKYNNNSGFVSNDERNTPQSFSHFTYEHSNHQLLIIDIQGVGDHYTDPQIHTYDGVGFGIGNLGQKGFEKFLDTHKCNAICQYLNLQSINPKSEKSDCGTVPRPDLIFPDTSERDNNNNNNNNNNNNNNNNNNNSNNNNNNNSSISKSLVEISSGSKERNDRDSPSRQLFVSNDGNTLNTNKERSKSKSIDLEKPEILINNKKKESINLETIKLIETIKGYHVTSHLCICDNLLFTGCSDNSIRVYDYKSQNMECVQTLKGHEGPVESICYNDQYLFSGSSDHSIKVWDLKKLRCIFTLEGHDKPVHTVLLNDKYLFSGSSDKTIKVWDLKTLECKYTLESHARAVKTLCISGQYLFSGSNDKTIKVWDLKTFRCNYTLKGHTKWVTTICILGTNLYSGSYDKTIRVWNLKSLECSATLRGHDRWVEHMVICDKLLFTASDDNTIKIWDLETLRCNTTLEGHNATVQCLAVWEDKKCVISCSHDQSIRVWGWN