lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
Subcellular Localization:
Cytoplasm.
Sequence:
MYYVTPRQLVFPGDVIATADSKVEGPVYLDNGKYRSLVVGLVEFREDVVVVVPLEGTYKPKKGDLVIGYVTDVLATGWEVDVRSFMPAYLPVGEALHRHVDLETTPLTTFLNIGDVVVAKVKDVDLTDEYPIILTLKDEKVGKVESGTVVEITPVKVPRVIGKRGSMLNTLMELGCDIVVGQNGRIWVKCKDPRDEVFLASLIRKIEAESHVMGLTDRIRAEIENYKTSKQQGTV
The following text describes a protein:
Function:
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein.
Sequence:
MSVLGERLKNGIIDENVTFVQVLAMCPTLAVTSSAENGIGMGIASTVVLMGSNLVISLLRKVIPDKIRIPAFIVVIAGFVTLLQFLMQGFVPDLYTKLGIFIPLIVVNCVILGRAEAYASKYGPVSSIFDGLGQGLGFTLSLGVIGMIRELLGAGQLFGHQIMPSSFQPALIMILAPGAFFTLGILMAIINNMKLKKAK
The following text describes a protein:
Function:
Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MLKGQKEGEAEPVPEGDKSGAGSSPSGVRKGLRVPLGLVSHSFSSLAKHKEAERRLTDEEESLSSPQDREDDAASPNIMAKSIAGLLTTASMYVGIGDIHRAEQLATGQPETDAGADETEDEMDEAGDETGDDADAPATGTDGEEESRPVSAQESRRSTLFELSIEPHPESHTAQASRTKNRRSRMTSKLRSKFNLDDDEELVREYPCWLLRDVLIQGHIYLTSRNLLFFAFLYKSNGSARLTGNLSICNNGLSISGISGKPTRYWTVLKDHTLSLYSSSTDLYFPVLTIDLRYVTKVQHCKNNGKDTRQFHITTESKTYTFYSDNEHSARSWSSALKKQVFATQNSDNDSMSVRIPLSNIIDVEEQAIVEQGLTLRVRVMESSDSFALDDYFFMFFNNAGSQLKELIQIQVANLEMLGAANVDYARHPLPPDTEASLPAVASDAAPQDAAIASEAAADAAAADTASHSPSTNAEPRARGRSTERAMAASAYLFGRLTSPRRDDAKQLSPSKVKLRFRSVADTLKLTTPRQPGSDAPQEPEPETTILESRPRLNYWSPRPFTTMRSMWNAQPVHYAAKGMSLFADDDELMIGDEAELLAADKRFKAHFSLTDDESLVASYYTYLNRSMPLYGKIYLGKTIMCFRSLLPGSKTKMILPLHDVENCYKEQGFRFGYFGLVVVIYGHEELFFEFASQKSRDDAEYVILKIIDSLKPVDGVMADDMSAGAYSLKAAQGRDATTDAKVKLFEQRISSVGYDIPIMVEDNPFYKTTITPKKFYTFGMLTIGSRGDVQPYIALGKGLLQEGHRVVVISHAEFGDWVRSHGLQFRAIAGDPAELMALMVQHGSMNVGLIREAASTFRNWIRDLLETAWEACQGIDVLIESPSAMAGIHIAEALQIPYFRAFTMPWTKTRSYPHAFIVPDQKRGGNYNYFTHVLFENIFWKGINSQVNRWRVEKLGLKKTNLEFMQQGKVPFLYNMSPTVFPPSVDFAEWIKVTGYWFLNESSNYVPPQALLEFMAKARRLDKKLVYIGFGSIVVKDPVKMTMAVVEAVVKADVYCILNKGWSARLGGQSQKSIEVQLPNCVYDAGNVPHDWLFPRVDAAVHHGGSGTTGATMRAGVPTVIKPFFGDQYFYANRIEDIGAGIALRKLNACTLSRALKEVTTNTRIIAKAKKIGQDISKEDGVATAIAFIYSEMAYAKSLIKAKRQEDKKAAKEAKQIQNEDSWLLL
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Sequence:
MQLNCIVKLHSMESSWGLKQCADGLWSLLTFPFSFPEAFEVVVRHARNFTNLMFRNYYRGIATYASPFVGDLFTDISLYILGSDLSVNDMVNEFFDGLFPLVYSRLVNPGLPEPSAEMAECLRLARRDVEAFGDVPKAMMTRVSRSLRVTRVFLQALNLGIEVVNTTDHLRLSKDCGRALLKMWYCPHCQDLLTAKPCAGFCGLVLRGCLASVAEVDGHWREYLHALEGLTKSMRGTYDVEHVLLHLFSSIRDAITHMQKNAGKMAAAVRPLRDNRSDYWLLIVIMVALVTLCIKNRKHFLFLVCKCYFQFNCALLILKVFVLIIIIIIIPYILEDKPSFSALIHELKKPPPAYNQVKVKAGNGVCRLLLAICDLFPSSPPLSVCFLLLLLAICDPFLSSPPLSVCLLLLAICDPFLSSPPLSVCFLLLLLAICDPFLSSPPLSVCLLLLLLAICDLFLSSPPLSVCFLLLLLAICDLFLSSPPLSVCFFFLQSLPRS
The following text describes a protein:
Function:
Component of the SRP (signal recognition particle) receptor (SR). Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. GTP hydrolysis may enhance the fidelity of and provide unidirectionality to the targeting reaction. It is important but not essential for cell growth. May be directly involved in mitochondrial protein import.
Miscellaneous:
MISCELLANEOUS: Present with 2000 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Thought to be anchored in the membrane through an interaction with SRP102/SR-beta, which contains a bona fide transmembrane domain.
Domain:
The SRX domain is sufficient for interaction with GTP-bound SRP102/SR-beta; The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the signal recognition particle (SRP) complex subunit SRP54 (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). GTPase induced rearrangement of SR drives SRP-mediated cotranslational protein translocation into the ER (By similarity).
Sequence:
MFDQLAVFTPQGQVLYQYNCLGKKFSEIQINSFISQLITSPVTRKESVANANTDGFDFNLLTINSEHKNSPSFNALFYLNKQPELYFVVTFAEQTLELNQETQQTLALVLKLWNSLHLSESILKNRQGQNEKNKHNYVDILQGIEDDLKKFEQYFRIKYEESIKQDHINPDNFTKNGSVPQSHNKNTKKKLRDTKGKKQSTGNVGSGRKWGRDGGMLDEMNHEDAAKLDFSSSNSHNSSQVALDSTINKDSFGDRTEGGDFLIKEIDDLLSSHKDEITSGNEAKNSGYVSTAFGFLQKHVLGNKTINESDLKSVLEKLTQQLITKNVAPEAADYLTQQVSHDLVGSKTANWTSVENTARESLTKALTQILTPGVSVDLLREIQSKRSKKDEEGKCDPYVFSIVGVNGVGKSTNLSKLAFWLLQNNFKVLIVACDTFRSGAVEQLRVHVENLAQLMDDSHVRGSKNKRGKTGNDYVELFEAGYGGSDLVTKIAKQAIKYSRDQNFDIVLMDTAGRRHNDPTLMSPLKSFADQAKPDKIIMVGEALVGTDSVQQAKNFNDAFGKGRNLDFFIISKCDTVGEMLGTMVNMVYATGIPILFVGVGQTYTDLRTLSVKWAVNTLMS
The following text describes a protein:
Function:
ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Binds and transports smaller and larger peptides with the same affinity. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Note=May be located in membrane rafts. Takes an intracellular route from the endoplasmic reticulum (ER), via Golgi and early endosomes to late endosomal and lysosomal compartments.
Domain:
Divided into an N-terminal domain (TMD0) comprising four transmembrane helices and the following core domain (coreABCB9). TMD0 is required for lysosomal localization and LAMP1, LAMP2 and YIF1B interaction. The core domain is required for homodimerization and peptide transport activity.
Sequence:
MRLWKAVVVTLAFVSTDVGVTTAIYAFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCLLLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMAKLLLFSEVRRPIRDPWFWALFVWTYISLAASFLLWGLLATVRPDAEALEPGNEGFHGEGGAPAEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDSIVIQKSMDQFTTAVVVVCLLAIGSSLAAGIRGGIFTLVFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQSALARASTTAEETISAMKTVRSFANEEEEAEVFLRKLQQVYKLNRKEAAAYMSYVWGSGLTLLVVQVSILYYGGHLVISGQMSSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLQGGRVLLDGKPIGAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQRHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLEHPLDYTASHKEPPSNTEHKA
The following text describes a protein:
Function:
Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling-activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury.
Subcellular Localization:
Nucleus.
Sequence:
MAAGTSTLLSLSGPADHMAEGKGAPLRPSVEKRWKLMEPKQTQAGMFKKMSLVDSDTAAGKGSQDEAYTELSLPTAPNKPRLDRPRACKAYTEQRHNTFTELSCLQERPGDIQAQTRKLENPEGQLGPQQLPSSFLRASGDGTVCSAWPGAPRSEQKSAFSKPAKRPAEKPKRSPMLLAGGSAEGSWELSGLITTVDIPYWAHLSTFKFMGDFWKLHTLSQNILLCNAFQGAPTPWLEHTQVQAPTSSAPSSTASRALLPPTLSSLGLSTQNWCAKCNLAFRLTADLVFHMRSHHKREHVGPDPHSKKRREEVLTCPVCHEYFRERHHLSRHMASHS
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MGFGLRPRFLIHILVISLIASSIINVAQGQSTADEYLTPHNDARAGLNQGIPSLTWDTTLESYATDWAATRAAAGDDCALIHSGGPYGENIQRMFSSNPADAVQAWVSEEAYYDYATNSCSAPEGEFCGHYTQVVWRDTAALGCGSATCPSGALFVVCSYDPPGNFAGQLPY
The following text describes a protein:
Function:
Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MDMIAAAYGCESDEEDSDPWASSRVSAKRTIGRDEEFSSRPFKKVPNRLPAPKLITHEEPDEVVDDPSQHGNRIRSFPHERGNWASFIYLPWEGDSNFVNSVELITQCFQNYGIELQICDDFHISLTKTFILRHHWIEGFVNSVKKQLNGISRPFQLLGTNVLSVYTNEERNRTFLAINIEDPSGMLNVLTQKMDSCMIEYQLPTFYKEACHHVSIAWCVCDKKEELEKIAAGLKLEIEQTACNMAEVRCKIGNLVKRL
The following text describes a protein:
Function:
Translation activation factor that as part of the MRH5C complex specifically recruits cox1 mRNA to the mitochondrial ribosome for translation initiation.
Sequence:
MRVCRTLKISIKSFPSSLSLLSLYKRRLHKSTSHSSTATSSHYSKNNLPSDSPDLLFDYFIDGHKIHVNPNAVEPLHLRRNADVVGFSLPHGVKQSFENYIQKYPLSDQVENSSNIYDPSSPPDSPRKQQTHLGTIPPEHPDVFFHNLKKKLDSLHTHSSPLTVYRNHLLTCETDSALAQLFKSEIYQQLSDFRRDFPLSHALRDTMLIARLNFLNPMLALSFFQAVKKHSPNAYVRGCSAPVYNQAILSVWQGCKDPNFVLHLLGEMRENVVMRDSETREAINIVYKDVNEWPKQLLFSQNRILEKLKIFLLP
The following text describes a protein:
Function:
Involved in the assembly of lipopolysaccharide (LPS).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Note=Copurifies with LptE/LptD, LptBFGC, LptA, DnaK/DnaJ and LPS.
Sequence:
MKYLLIFLLVLAIFVISVTLGAQNDQQVTFNYLLAQGEYRISTLLAVLFAAGFAIGWLICGLFWLRVRVSLARAERKIKRLENQLSPATDVAVVPHSSAAKE
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
Sequence:
MTREPVRMTRQGKERLEEQLQYLKTTRREQISEYMGKAIEDGDLRESAAYDEARMQQSENEAKIAEIEAQLERAQIMKDEEIDTSAVGVGARVIVEDAQNKQRTLEIVGSFEVDVLKGKISDASPMGQALLGKRPGESAVWPGPKGNVSLKVISVEYP
The following text describes a protein:
Function:
This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. Principally active against barley beta-glucan.
Sequence:
MRLVNSLGRRKILLILAVIVAFSTVLLFAKLWGRKTSSTLDEVGSKTHGDLTAENKNGGYLPEEEIPDQPPATGAFNYGEALQKAIFFYECQRSGKLDPSTLRLNWRGDSGLDDGKDAGIDLTGGWYDAGDHVKFNLPMSYSAAMLGWAVYEYEDAFKQSGQYNHILNNIKWACDYFIKCHPEKDVYYYQVGDGHADHAWWGPAEVMPMERPSYKVDRSSPGSTVVAETSAALAIASIIFKKVDGEYSKECLKHAKELFEFADTTKSDDGYTAANGFYNSWSGFYDELSWAAVWLYLATNDSSYLDKAESYSDKWGYEPQTNIPKYKWAQCWDDVTYGTYLLLARIKNDNGKYKEAIERHLDWWTTGYNGERITYTPKGLAWLDQWGSLRYATTTAFLACVYSDWENGDKEKAKTYLEFARSQADYALGSTGRSFVVGFGENPPKRPHHRTAHGSWADSQMEPPEHRHVLYGALVGGPDSTDNYTDDISNYTCNEVACDYNAGFVGLLAKMYKLYGGSPDPKFNGIEEVPEDEIFVEAGVNASGNNFIEIKAIVNNKSGWPARVCENLSFRYFINIEEIVNAGKSASDLQVSSSYNQGAKLSDVKHYKDNIYYVEVDLSGTKIYPGGQSAYKKEVQFRISAPEGTVFNPENDYSYQGLSAGTVVKSEYIPVYDAGVLVFGREPGSASKSTSKDNGLSKATPTVKTESQPTAKHTQNPASDFKTPANQNSVKKDQGIKGEVVLQYANGNAGATSNSINPRFKIINNGTKAINLSDVKIRYYYTKEGGASQNFWCDWSSAGNSNVTGNFFNLSSPKEGADTCLEVGFGSGAGTLDPGGSVEVQIRFSKEDWSNYNQSNDYSFNPSASDYTDWNRVTLYISNKLVYGKEP
The following text describes a protein:
Function:
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MPFQIFASGESAHEAFDLNEVIVHHLMDNAEFPFNIGGVKVFEGESDFDSSKETIFTDHETGKRFHFVGGFDMHITKRVTMMWIVALLLFLIFIPAAKIIARNPLQVQSRFANTVEVFVNFLRKDIVDESMHGHGHGYYHYILTLFFFILFCNLMGLVPSVGELIAVAGDATGMVHLDHHNPPWIAKVWSGITVTGDISVTMTLALLTMFLIYAAGFIYQGPKFIWHSVPNGVPLLLYIIMWPLEFIVSPMAKTFALTVRLLANMTAGHVIILALMGFIFQFQSWGIVPVSVIGSGLIYVLEIFVAFLQAYIFVLLTSLFVGLSMHRH
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MPPSIKHLYAGQTIFITGVSGFLGKALLEKLLRVAPNIERIYVLLRPKKGQQPTERLKTILQTKLFDSIREASPNFTEKVIPIFGDITLENYGICESDLCDIIANTDIVFHVAATIKFDELLRKSILQNVVSVQTMIRICKRMPKLKSYVHVSTAFCNTDKEVIEEVIYSDIVPPQKLIDAMSWMDDDMISQVTPKLLGRLPNTYTFTKKLAEIVIATEGLNLPIAIVRPSIIGASWKEPVSGWIDNYYGGTAAMVLVAKGLLRRIVAKEKCKADLVPVDYTVNMLIAACWHAVHASKQQTPLIYNCCSSPDNPFVWGSWLSLTLKNSYEFPHDQVFRMPSCSMNGETNRFHLFMQHWVPAYIVDAWRFVCGKKPRLINEYDRIHRSMTAFEYFTCTEFKWTNKNAKKLWQTMTPEDHKEFPFDFTELNWESYISNYCIGIKRYLMNEDLSNLPQAKKKMARRQHIRWGTYALLVFIIWRVIFSKSMWDKSLWLSRINTYLKTTRTLLLISP
The following text describes a protein:
Function:
May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short-term and long-term synaptic plasticity.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Melanosome.
Sequence:
MEGGAYGAGKAGGAFDPYTLVRQPHTILRVVSWVFSIVVFGSIVNEGYLNNPEEEEEFCIYNRNPNACSYGVTVGVLAFLTCLLYLALDVYFPQISSVKDRKKAVLSDIGVSAFWAFFWFVGFCFLANQWQVSKPKDNPLNEGTDAARAAIAFSFFSIFTWAGQAVLAFQRYQIGADSALFSQDYMDPSQDSSMPYAPYVEPSAGSDPAGMGGTYQHPANAFDAEPQGYQSQGY
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in proline-rich peptide sequences of plant glycoproteins and other proteins. Hydroxylates preferentially prolines in second positions in the -Pro-Pro-Gly-triplets. Hydroxyprolines are important constituent of many plant cell wall glycoproteins such as extensins, hydroxyproline-rich glycoproteins, lectins and arabinogalactan proteins. Can hydroxylate collagen-like peptides and hypoxia-inducible transcription factor peptides.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing P4H1 show absence of trichome on leaf and petal surfaces, increased root hair and reduction in seed size.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MAPAMKIVFGLLTFVTVGMVIGSLLQLAFINRLEDSYGTGFPSLRGLRGQNTRYLRDVSRWANDKDAELLRIGNVKPEVVSWSPRIIVLHDFLSPEECEYLKAIARPRLQVSTVVDVKTGKGVKSDVRTSSGMFLTHVERSYPIIQAIEKRIAVFSQVPAENGELIQVLRYEPQQFYKPHHDYFADTFNLKRGGQRVATMLMYLTDDVEGGETYFPLAGDGDCTCGGKIMKGISVKPTKGDAVLFWSMGLDGQSDPRSIHGGCEVLSGEKWSATKWMRQKATS
The following text describes a protein:
Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRFAFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLNIAESDTGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLFPSNELSHINKPILNMDDNPYSILERVEQVDVVPTICLLLGIPIPKGNMGKVLSPVTELWKDTKTAKMAALSNLFQLSLLKNPSLTTSELSTQFQDSDLNDIRLALENLQSQMVAQSSSYSLDRMLVAISILGACSILSLILFRNLYNYKELLAFAPFVVQNIIIVFSSSFIEEEHVIWYFAAVSLSLLQLLNPKTRLAGSLQLFCLSIIKRWNQTGQKYSDLRDIVDDFIAPSTFMKTILCVTSAFMPAIRSPSPINFLSSMFIAFYKLMPIISKHLNELPIIASFDYTFFVRIIWSLLLISFLSKPTFKQLRCQLSLFILLLTRLENMGLYLLYDIWQRTMPEEGTLASVMYYVAEQVAFFSLGNSNSLATVDLSQAYTGLDSYNIFAVGILLFTSVFAGALWWCLHQPKRMMDRSVKTFWIMSSISLTFLCISCFIMRHHLFVWSVFSPKLLYNASWASMYFLAKCLISTIMVRLR
The following text describes a protein:
Function:
Key component of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation. RqcH recruits Ala-charged tRNA, and with RqcP directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal alanine extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.
Sequence:
MQAVDYTTLMAIVAELQGDWLPARIEQIYQHDRHGLSLALRTLERRGWLTLAWHPQGARICLDPPPPQEPDTFTFSDQLRHQLKGLALISLKPLQPWERVIDLAIAKRPGDEPLYHLFLEVMGKYSNLILTDAQRQIITVAHQVNSQQSRVRTVQTGQPYQSPPALLATPPSLTESFSSWQERVQLIPGLLSKQLLKSYRGVSPMVVKNLLGQADLDSQVSNQDLTDEQWQNIFIAWQNWLQRLEKLDFLGKSLPQGYIVLAETTVVNDVKPTQEEGDRPLLPINKLVSEYYRRELGRENFQQLQHQIQQKLNNLIAKLQQKADTFKQRLNAAANAQQYQRQADLLMAYLHQGQPGLSSITLPDFDDQSPVTISLQPDKTLIQNAQRLYKQQQKLNRAEAAILPLLAEVEQELAYLTQVETSVQALTEFDDLADWQTLTEIRDELAEQNYLALSHGRPRRKEAETFEPHQSLTPSGFPLWIGRNNRQNDYLSFRVATEYDLWFHAQEIAGSHVLLRLPPGAIAEDQDLQSAADWAAYYSRGREEEQVPVVYTQPKYVFKPKGSKPGMVVYQQETVIWGKPGAVNPKLTHN
The following text describes a protein:
Function:
GTPase-activating protein for members of the Rho subfamily including Rac1, RhoA and cdc42 and other Ras-related subfamilies including let-60. Mediates radial (inner-outer) polarity and gastrulation by excluding par-6 from contacted cell surfaces; acts by inactivating cdc42 at inner cell surfaces which limits active cdc42 to outer cell surfaces devoid of cell-cell contacts, where cdc42 can bind and recruit par-6. Required for blastomere polarization.
Subcellular Localization:
Cytoplasm. Cell junction. Cell junction, adherens junction. Note=Locates to inner but not outer surfaces of early embryonic somatic (EES) cells. Specifically localizes to cell contacts in hmr-1-dependent and -independent manner in embryos.
Sequence:
MEEHHRRLHVKAERASVIGGDIVDGAFGSWALRAARSEHQLKQQSNEDLAQNARISALLGEMRPRMSAMPPNGHQQQYQPQLRRKANTTNIVDVSSQVPSARNAIYGSWQDRHRPTRLYGSQLVSSSSTLPKYDQLYCNTASPLTGNGSTNTIATTGIRREPPEYGNVGRSVSTWQVTNSEHRPSLQAGWLKSSRPLARGALSPAAYFRDLENRHGSGASSPIVGGLSVVAVPITQRHAPTAGLAPISDDISTSKVSLDTENQQLNNEDSDKISGSALSRNTPRQASFMAAMQRHPLKESSTSIESNGGGTNTEEDQTVSATSKEDPSEDTGHDDPEETQEISETPIRRSRNRNASLRNRQSSRSLGGLDFEKLRMGTARVGDSNEATAENGTSSSSSRKNSRDDGLTSSPTTVAGPVFTTSSTSSISTSGEASSTAVAAAAAGSVAATTSRQTSSNSSVDSNHNEAMKMIRRARPKSYVLATSASMNEDVLSSSIIANEQSSSISHDTTTSGRELPSSLMGSTISMEMRSGGASSATTTTTSNSGQQTSRSLNAPHPPATHRLQRFIALFNSSKTSDGSGEHKKSRMKRSRTSLPASRFALPGTILQRDGVARQTWVKHQEIALGKSGKRNNWEDRWAVLCRRSLYLCVESPAYTTEKTIELGSHTRVDVCNAIVDIAYDWLSSSFSKQRHVVRIVTQNRSEHLIELNTESEMLSWISVLQSSSEDGIATGSSVDENELSTTGRHNNNAVSNSSALLHNSQSIASLASSSCSTATTSEFLNSQHTLQQQQQQQTNQKHQQTVNELSAGIVSHLPTSKSFGGLSTTASSTTENAKNRLIMHRYIAKNSQLQSPTANKKMETDPSTVPSSSQTMATTSSSFHHHSSQAGPSRDIENGEAPTATATTPKSGRKWKKSKAAKQGSGGGSSGSSSGSQQQGAAGAPQPVLGVRIADCPTGSCEDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSKVESLDPRWRDVNVVSSLLKMFLRKLPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPSDDNMATMVTHMSDQCKIIETLIHYNLWMFDESSTTEDAVPEQHPADGQNPLEPGGYGVGVPTGVSAASFNDMHNLIRKANEDQAAAMMNEGKGQKIKNMLRRNSRRDKSKSKLKIESTAPAAVNPRGWTQPTPSNTSAASVESAFCGNYQERDIDAEIESRQTVSPQMTSGSADGASSTRLDQSPSLESSLGSLPDTSRTEPILGSSGYDDDEAKEAARRKRQEEMYSARRIFIAGAAGAAAAATTTADAEKAAIDALANHSQHLHLASSPAFEVLSEETREKIRRMQKKQSWHDTKELRSGELLKTYSPTKDLTDALSCTSDYSTTSSAPLSTNPPLAVACADQPNSSSDYASSDPSPCARNPSTSPASRPSNLAISPAQLHATSSSGQSHQPMSRSQKIRLRTKLGSRDPARRHTLSDVDTLKEGRLDKLARWFGIRKSSPDVSRDEVSDDEKNHQEAPPLPAAAPPVIVRTSPNELTPVSGDELL
The following text describes a protein:
Function:
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Subcellular Localization:
Secreted.
Sequence:
MKSLLLLSVLAALAVAALCYESHESLESYEINPFLNRRNANTFISPQQRWRAKAQERIRELNKPPYELNREACDDYKLCERYAMVYGYNAAYNRYFRQRPGAK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
RGGWRGSPKGGGVPGWRWGGEKGRGEGGGGGRGPLCRRSESSGGGSQEAAGPRAVCWRLRELSRRWLRPERRSKEQILELLVLEQFLSILPEEIQSWVWVRHPQSCAQAVALAESFQTGWEKQVTVRVKLEEVPPGNTEDPEVVLDPPSPPPEPTGDEWWEGNGRSDPEEEEEEEEEERSLQETAGPTAASTEPEDPILTTQDPPHPPSIPQGGPTTRTPTQTETHRRPRAIPKDPTAFPPPQTPPRPTEDTGNTEKPWAKPPEHGKERPYPCGECGKTFGRLTHLKTHQRTHTGVKPYACGACGKSFGHLSTLTTHQRLHTGERPYACGACGKTFTNPSDLNKHQRSHTGERPYPCAACGKRFSQQSNLTMHQRSHTEERPYPCGVCGKSFKYLADLTVHERSHTGERPFPCAQCGKSFSNKSSLARHTRIHARAATRDK
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MADDDDGLQLNICYLNKAPPKKKSDIDEDAFFKENISNNSRFSTNKLYKGKQTNEINNNNKNNNTQNNNYRNNNNNNNNNNNNNNNNNNNNNNNQNNNYRNNNQNNNQNNNNNQNNNQNNQNNQNNNKKPTYLEKRIALEQKQKELKESKGPQVHRYNSNNNNNSNNNESNNINTTNSKNDTINKFKLAEKNAEKDELNRPILENIEPAISKLESFETFSSMNFGSLQLSETLVRNLQGHMKLVKPTHIQEASIPTILKGSDALVKAQTGSGKTLAYLIPVVQKLTEQRVSRADGCYCVVISPTRELALQIFDELQKLLKPFYWIVPGLIMGGENRSAEKARIRKGINILVATPGRLLDHLQNTKTFPTHNIKWCILDEADKLLDLGFEKDITTIINILDEKKKSNGVPRQNVLVSATLSDGISRLASISLKNPVYIGLDQRALESGENPFDAAMKEELLAPKQLDQYFVEVESKERLTSLVSFIRWKTSNINTDGSKSVNNEQQKMIVFFSSCDSVDFHFYAFTHLKMDKERGLSKSIKEKLRDERKKQQAKQQSSKIFHTGNSDDEESDAESDGGNDNGSDSDNTDDEKEKINTDSVRNTRSKTSVFSVPVFKLHGELDQQTRTKTFFDFKNSSNGILLTTDVSARGLDLPSVSWIVQYDPCSDTKDYIHRIGRTARLGNAGSSLLFLLPSEKKYIQHLENYKLQIREMKVTSILQSLFYTSEGQLKKNSKASQLESIVHDLQLLFERFLIYDSKAKELARCAYQSSLRAYATHKGDVKSIFHISHLHLGHVSKSFALRETPTELNKMSAGIKGAKAAKKGDESTLQKQTIDFKMKSYKSVNEFSDGLNDQPLQKSNFHYQSESGTIHNIFQRHFDRNKQNDDSDNEDNDSKQKKRRLYDKKIKDNSKKFKSK
The following text describes a protein:
Function:
Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
Sequence:
MRDGFRIGILGGGQLAKMSAQEARRMGFDVLVLDPTPGCPASMVAEQIVGSFQDGEMVIELAERADVVTYDIESVNVEALKKVAKEKPVIPEPHVLEVIRDKYVQKKVLRRAGVPVPWFRELKSLDELENLIPVVQKARSGGYDGRGVVVIRDEKDLQKALNVPSYVEELVPIEKELSVIVVRNDDETLAYPTTEMVFNNEGNILDFLVAPGRVEKDVEKEAEEIAIRAVEALDGRGVFGVEMFLARDGRVLVNEIAPRPHNSGHWTIEAAVSSQFEQHVRVVADLPLGSTEVVLNAAMVNLLGEKGYYGKPVYDGVSEALRIPGVFVHVYGKREVFPFRKMGHVTAVDRTLPGAIEKALRAKALIRVRGEVNAQSGNNNG
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MIIPIRCFSCGKVIGDKWDTYLTLLQEDNTEGEALDKLGLQRYCCRRMILTHVDLIEKLLCYNPLSKQKNL
The following text describes a protein:
Function:
Component of the synapsis initiation complex (SIC) necessary for the synaptonemal complex assembly. Stabilizes the ZIP2 component to the chromosomes. The SIC complex loads onto chromosomes and nucleates ZIP1 polymerization, a molecular zipper that acts to bring homologous chromosomes in close apposition, which is required for meiotic crossover. May also be involved in double strand break repair.
Subcellular Localization:
Nucleus. Chromosome. Note=Synapsed meiotic chromosomes.
Sequence:
MGGYLAIVFIPQTNTKSMREKKQKCLKQVRRLSLISPKKYIMPDSIFEQPFVYCGVCHRRTSHGDPLRLTSCAHILCSQHSPLTSKVCPICRSSDISIINLVESKQLPTDIRIFFEPLPPLLESLYNVSQFQLNGLSKQCQYYQNHCLKLREKCARQQQLLYQAKIELDSMAILKKRIQELESVLNHNNVSSMSVGVLPTRNSHQNHYQPPPTVDLTVDDNSLEEFEAKSFIKKLKKNSSLRNSSKNNNGTVTPSTSGRVNKNQPLFMETLNNPNRNSIPPPGMNPNANSNLPNISTIAESTNLNRFSFSPVRVAKGFDGKLPNLDILTNNGSVSSKNISRLSSASLQPSSPLSSSSNRLILPNSNLKELHHSNTPLTSTSTQFPSALEKLKITRKRNNTISGSNRITHNLSSHVRSSGLAFSSSSNSLQQSKLPKSNILKRSNSTQQLTNTHLKSDNHLPPRSSNTVLGSSKKNNKFRRIR