lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH); Possesses non-specific lipolytic acyl hydrolase (LAH) activity. Hydrolyzes phospholipids as well as galactolipids. May play a role in disease resistance.
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MAGGSSATAGDEAKVITILSIDGGGVRGIIPAIVLAFLEKELQKLDGPDARIADYFDVVAGTSTGGLLTVMLAAPDKDGLPKLKYSAKDAAKWGILSWLIKDGSVPILDMFNAGSADMVDFHLSVLSAVLGTSHQYLRIQYDKLSGSAGSIDDSSKANLDRLVKIGEELLSEKVSGVDLETGRNVEVPGGGTNAEELAKYAKQLSDKRRKRRNN
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MAKSGEKGSVLVLVAFAAAILLLGAQVKPAVADGYNTDIEGKVRGIVNARIYDAPGLIRLVFHDCWVKGCDASVLLKRADGLAEMDAVQNGGLRGLDVIQAIKDALTKDYPAVTCADAVVYAAREACYILSYGKIAYPVDGPGYHKDAVGSFKDDAAALPPPFGPSSSFKNLTKNFGGKPGFGAGDLVILSGAHAVGLAHRPAFVDRLDLQVAARGEIDVLYQKKIDQVSNASPAKAIHNNVRDIDQPETVPGVLDNSYYAANLGKKVLFNSDWALITDPAARGQMERFEKFPGDWYDLFGKAMAKLSRLPAEGPTLSVPRARCDGTSY
The following text describes a protein:
Function:
Required for normal spermatogenesis and male fertility. Plays an important role in sperm flagellum biogenesis.
Subcellular Localization:
Cell projection, cilium, flagellum.
Sequence:
MPGDEQEAKKAAQRTEEGVHITEALITKRNLTFPGDEDLSEKMFHTLGELETVRLDGEGITCIGNLEKLRNIHSLYLQSNKIQRIENLACITSLRFLSLARNQIRHVENLLDLQYLQFLDLSENLIETLKLDELPESLLILNLCGNPCTNQEGYRKMVIGALPLLLDLDKQPILERWTSDEEDKSSDDDDEFPELNGPFCAERGFFKDLEQELHQHQERRQQAALTEHLSRMETQPVLTDLPLLPAVPMAGDCSSTATDQPGKESAPKATSSTQTASTTKKQVSKNQKSSVQARKGALAATTSKTSQAATPSMTKMTNKKSTK
The following text describes a protein:
Function:
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Plays an important role in starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions downstream of the ulk1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and maybe other phosphoinositides including PtdIns3,5P2 and PtdIns5P, and is recruited to phagophore assembly sites at the endoplasmic reticulum membranes. There, it assists wipi2 in the recruitment of atg12-atg5-atg16l1, a complex that directly controls the elongation of the nascent autophagosomal membrane. Together with wdr45/wipi4, promotes atg2 (atg2a or atg2b)-mediated lipid transfer by enhancing atg2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes.
Subcellular Localization:
Golgi apparatus, trans-Golgi network. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Domain:
The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane. Association to the membrane can also occur through binding to phosphatidylinositol 3-monophosphate (PI3P) (By similarity); The L/FRRG motif is required for recruitment to PtdIns3P.
Sequence:
METGGGGDGTGDICCLSYNQDCTSVAIGMRSGYKLYSLSNVERLDLVHESCEAKDVYIVERLFSSSLVVVVSHAKPRQMNVLHFKKGTEICNYNYSDNILSIRLNRQRLIVCLEESIYIHNIKDMKLLKTLLDTPRNPHGLCTLSINHSNSYLAYPGSSSTGEVSLYDANCLKCECTIPAHDSPLAAIAFNSTGTKLASASEKGTVIRVFSIPDGQKLYEFRRGMKRYVNISSLVFSMDSQFLCASSNTETVHVFKLEQLPERSEENASWTGYMGKMFMAASNYLPTQVSDMMNQDRAFATVRLNFSGQKNACTLVTIQKLPRLLVTSSSGHLYVYNLDPQDGGECVLIKKHSLLGSAKSETDGDSDAESPVPVSYAATVARPSSAPALSTITGYSEDGGTLRGEVIPEHELAVGPVCLDDEKEFPPVSIKNP
The following text describes a protein:
Function:
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
Subcellular Localization:
Cytoplasm. Nucleus, nuclear pore complex.
Sequence:
MASEGRCWEALQAPRSSDRGPLSYPSDWPLRGQETLEERMSIPEWSTSSGCVADHILPPSQQNRLPSEDSSLSSAPDQVLSVPQTPARHAKVSSPVSLAAPSGTRRQEDELHQAKSVVLRPSRGTEVEGCIRLYEEVHRLKGTRGLRQRQEEHERKARLLSDMASEQLKRFDERTSRKQHKEYQDLREGMEKSFRETQGQQEQLQEEHRHRAHMLHPKLREAEQQPSRHTGQGRLRKEEGQDRWRRLYALQEEALQLNQQLGASYRHNGLPRRDLSAFGGRGDQLCALISDIIRSASERGFPAPEDEATAERALQEMRHVLTGLQQEMAKATEEKRRPDEEECEDKQGQLEQRPRAEKETPDPGQCPGGKQREGLHVKAGDGTMQWYQQLQDAANQCVLAFDALTNSKDQEAKKIKMDLQKAATIPVSQISTIAGSQLKEIFDKINNLLLGKAVPCGGRSVSVTNHQQGLDFVHYKLAEKFVKQGEEEVASHHEAAFPIAAVASGIWELHPRVGELILAHLHKKCPYSVPFYPAFQEGMASEEYQKLLGYQVKDSKVEQQDSFLKRMSGMIRLYAAIIQLRWPYAERQGAHPHGLNHGWRWLAQLLNMEPLADVTATLLFDFLEVCGNALMKQYQLQFWKMMLLIKEEYFPRIEAITSSGQMGSLIRLERFLENCLQQGEIPVPKGSLPPSFWLS
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Golgi apparatus. Vacuole membrane.
Sequence:
MEECKLDINKGKDAEILYEEYKYHEIKEMSFSSCARTSPELLKKFGCDAHVITSVEGAPKKENKKIWEFFKGSNKIKNLFTMFTCCFANDEEEIWGEETNESVVYKEYTYNSRWKIEIPSYPVREIPYVVADTPYNKLLCPLSSLEWVSKLILMDNANSIGMKNNRYSTNPFIYGMCYIIRNNANRILLESCYCENSTGMSTCPRILEFMPYEPLLKYNSYRLLSTYENSYKELSEMLTNNNAPLEVLIHHVMLYHYYPSFLQSALWTAVSSYLEERCNNGLYSKLLVKAAKQHFGDIRLYFVTPDDIYTFDHCNNWIAIVTRNFMAYIETKRKLEFDSIPFNCPLITQLFPLISSPKEMAWLLLIVCTDSNESWFPVHAYINTKTRILRPRSPKLDFFLKESDLLYFQDKQSISEFDIIRKDLLEDLIQCDSYVNTREQLRRRRETLNRKRITIAKLQNNHSQITFPYKRHNIHKSVDSIQFCKPASNLLTLKDNSYTQIPLEPLLLAEISV
The following text describes a protein:
Function:
Involved in the lipid remodeling steps of GPI-anchor maturation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRIFLNRGPSSNFSTWVFILTVPILKIRSSPGDYSPGYQRCVNYCNFENCFTVDENPKALPFSLRLFHWTCTDNCAYQCMHDLTQKVLKLPRAVPKPGQTFEGWWDEPDWEPGTELEGLPPGRIVQFHGKWPFKRWYGIQEPLSALFSFLNFTVYALSYRKMKRLIPLDWPLRAHYLGVAMVGMNAWMWSILFHCRDKPWTERLDYFSAAAYSLYGLYVSSIRIFRLYPTHARHYIPLDQRLHIGSQLKLIMSAMFLVHIAFLSFGERFNYKYNMAVNVIVGVLTILLWLSWTASHSHRPPKGLPAKLDVDEDLISSPQSEQSESPPPSPARPNGFFSSAWLSLLYESIPAVTETGIEPPYVSKPIIPLVCLIGAGSLELLDFPPVWNMSLDAHALWHLATTPLGWIWCVGFLAQDAQWESQFVEGINRPGSDSKEAEATAKSTPSKSPPIITTTKVD
The following text describes a protein:
Function:
Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis. This cell-cycle arrest depends upon inhibition of the G-protein TEM1 by the BFA1/BUB2 complex.
Miscellaneous:
MISCELLANEOUS: Present with 1380 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MSIRPLTLNGLDEPETSFEELNTTLPRFQSHETLTLEENVPPLSTSTYIPPPSSVGTSDTGTVFSNSTSAFWSNKQADDDQDMEVDQDDEFLNDFQEFQNKKDDFDDAIKTNFHLRNGCRTGPFKNDIFAEEFDRKLSLEDKPRLKQPRSMMELKPKRKLSNSVTSRNLRSGNSVRFKKSMPNLALVNPAIREEEEDEEREREDQREFNYKIDNDTQDTILAKFSSDDEGDFLTGFEELEGEAIDETISSNDKESADHPRFLKKSSSSLPLKISPAQYDIVKHDELLTPGLHRRQRDWNTQQELDSFKEKRSVRHCSNQNVQLNGPAKIKTIKQQIDHNTPMKKGSMIYNPKTMKWEGNENVLSKFSDVDTANRKALLIKNKLQRDADSKKQKYSDLQHARATSRNQKVIGNMILDEQNLRWVSVSEEEADPFAGIPEINLPPVGKSMKKRSSSPFLRSKSQVNTPFVSNDNDGVYQSTAAQARLRKYHSMRTLNGTTETPEISSTFHLSSRALEKFYHEENRWCKKLASWFIPRDETIISVDEETIMDESTVNSKRKSYMYEIRNMVINSTKD
The following text describes a protein:
Function:
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MIVDTFTNRGSTFFSKLSTVLFFLCAVITFQGVIQRREVELDTPVYVHYAKYRSARFYHAFRNVRQQYAQVKFNMDADLSELWDWNTKHVVVYLVASYSTEKHEKNQVVVWDKILSSPEESKMFMKDTLSNIQAHPFNEYSNQFEGKNATYTLHWTVSPKMGFLSWGAGPGSYEIPFHKIITQPK
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
MAVLRYDGDLESEMGWGKGLVRRKIGPLGLRNLGNSCYLNSVLQCLTYTPPLALFCLKKQHSSLCDSVNLNQKQDCAFCILEKWIHKSLTVELAMDAPSKIQSSLHIFAKPFQSGRQEDAHEFLRYVIDACQNTCLKLLREKNKAAERGGEVKANSTIVKEIFGGVLQSQVKCLSCNMESNTLDDIMDISLDVYQSTSLKDALRRFFQPEVLDGSNKYKCDKCKKLTAARKQMSIFRAPYVLVIQLKRFEGIHSGKIDRAIAFEESLELSAHMCKAGQDLQPEYSLFGIIVHSGYSQDSGHYYAYVKDATGRWFCCNDSHVSVATTQDVLSEKVYILFFIRTNQGSKSRKSGFASIGVKPSVCNGNGTSVSQKLCEPVEPPANRPSTAKIYQKYSSPCLETGKVLLKPQIKFANLKPAASESQRSDANGKVIQEVYNRASIEKHVNSKESTVSVAKENLPSSIHLNANGNRPADSSPEIKNTFFSGSVDDQKVNECFNKSNHIDHTDKVSVGEDKGVVSKNSHYGNGNYHCDRSVSKRKSHDNSSADVDTSVAANSCSSSKHDAGGEIAIDSCRKMDLAEYKQIIQHDLFDVLQQY
The following text describes a protein:
Function:
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
Sequence:
MFRIRSKVKYKKTNKRRDSPPSAEIEMDSDEDVSTVLPLSQRPEWSDITPVPQNDGPNPVVPIAYSEQFAETMSYFRAVYLADERSVRTLLLTAEAIHLNAGNYTVWQFRRVIIEALNADLHDEFDLVEQLASKNSKNYQLWHHRRWVAEKLGTEAVSRELEFTKKIFLNDAKHYHAWSHRQWVLLNLGGWEDELAYCNELLEVDIFNNSAWNQRYFVITRHPKLGGIEATLDSEVDYTIKAILTKPENESSWRYLRGLYKNNMQSFVTNPKIPTLCLDVLTSKVYPVFALSLLLDLISNGFEPNQDLKNAVEAVVPESNSQGLDIAATICTVLEIIDRMRVNYWGWRKNNLRSQVAEGVANLSIH
The following text describes a protein:
Function:
Nuclear import adapter that specifically recruits the two functionally and topologically linked ribosomal proteins rpl5 and rpl11 (encoded by rpl11a and rpl11b). Guarantees that this cargo pair remains bound together from the time of synthesis in the cytoplasm until delivery to the nascent 5S rRNA in the nucleus.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGRANGKRRNHRKNRMNPIQKKGFLEQEIPLNNSEAALPLLSRLDNPEIKERSWACSAISNIIASCTEGRLYLLKNGLVSKLIDRISDDSVEVVVEATGALRNLAIEEGYSICMDMYRKNVLAPLQIWQTKIVQTLDEATEGKNVLETYEDRSTFSCLCAIAENISSLLVNLGETTSQVIKVLNQKNTLVFLSRLLIPEAKIPQSVQEMALQAFFTLTDDNDDGIITWIQNSSDFALKTINQIYLYFSYPSCLVRVYSIGIIYNIYQSGFVNKKMESVVKGISLFDSFIPEALPILSDLLPSEENYRNLVRQVYDKDTYFKTKKDDLTLSSELLVIPATLELISSMTSLLQSLADGTDELEEQEDSLMEDEDLSYMDDMSNVVNEDENLIIDEIPSNTPQKGNFKLVEYMLDHVLPKVITYCVVAFEFSSEEIPSNLSNYFQEVGDRTIECLNNISWSCNSVFVESSEAFTRWKLSAGKILQWIFQTIFLRLGLGVWPFSSEGFTTACSLLWSVSKPFPAEIQVLSVDDISTLILFSSTHGSLEAQSRLLGAFGSLGRCGNIQINQLLGQTLMSCVIASDPNPLLAVEALNAIFDVYGDKSYPYDAPVFKGSGYLSQLSEALPRLKNMVKKIDRRREKHLRFRAEEALENLESFIDYKHAEYAS
The following text describes a protein:
Function:
May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
MQSNNRNAQSSAFTDDTDMRKFENSCAISSSDTGPLHANTSRIISGFTAHASKTNCLRIGPKSGRVIVTGGEDRKVNLWAVGRTSAVLSLSGHSSPVECVCLDWPEELVVAGSSSGSLKLWDLEHAKVIRTLSGHRSSATSVQFHPFGEFFASGSSDCTVRLWDVRRKGCIQTYSGHKNSIDYLEITPDGRWIASVDTDGVVKIWDMTAGKLLHTISGSSESVASLSFSPSEFILATSSLDGNFHIYDLQNFECISSSFQKLNGVSKISFSGDGHTLATSSVGTFDIWKWDRPQQSPMSFASGWSNIVDFKFLSDTNSIIACSVEQSFVEVWAIDITASPKGRKGSAAQSLYQTTKDSLAQVEHTAEQLSTGSVFPSAQLDQQIPSEFFKNATNLTDSEANDNSLHQEKGNSISGNNIFMPPEFSQLNLESNENAATEPIQSLQHELPNSRSLNSLPLYTGYMPSQSFNAPADSLIEQSCSIASSSLNPKQLSGSIELNIQPFTTSQSNTSSYIPACDGNRPLNLDLSRFIKHQFPGRAMHPIPLSISDTSSTVSSDQDVIESVLNRHVSMVTVLNTRLENIRLVREVWSENNPKLALDVVCKLEDRSVLVEFLRILNLRPRLLTLEIAVQILPLSCELLFEMYEDYIQIACSTVLLLYKNFSGIIMDTLRASRTPVHTMDMAFEDRLNRCRSCLDGFTQFSQILGEMRKYHGKLGDQIREISTELELFCESAY
The following text describes a protein:
Function:
Required for cell survival under thermal stress.
Subcellular Localization:
Endoplasmic reticulum. Cytoplasm. Note=Under thermal stress, relocalizes from the ER to cytoplasmic foci that are distinct from P-bodies but contain stress granule markers.
Sequence:
MEHLSNLEQPTTMDSYDFQKLTNDENLQGTESQVPSGSKSASTNGLLSAASSAAGSSFGLTPSAILQQKHENAQQGKKQNNSKSFSKKPAIDVHSEDAFPTLLSKTGPSKPRIVSWVRKTASNTSVAGSDSVSRDKIPFSASSRASSTKSTLSSVKETDFVTETLILSPDNQAPRMSFVGKPNSVAEIVRTVMHQTSTRINVSTASKTKNTTFLIQGKTSAVKAARRQILKLIGRRETKTMPCPVFVVGAIIGTNGQNLKSIMDRTSTRIQIPKRNNTANESSDDAKKPEKEENSAASTLDDLEPQYEMTTITIEGDFEGVELAQKDIEAIINERTSNTTVRISHISTELYSLLRGPDGKNIKELEEGRDLKVQIPFAYLDPSAPVNPIVLSGEKSAVRECALYLQGQAEELLRTTIPTMLPIPRRQHRFINGEKGVGIQDILRKSGCSVILPPINGDSDVVSVRGPALNISEGIRLTLERANSTIVDAVNITTAYASSKNPFDIASIVARLFLRSRKLIPLEEECAVQYHLPKREELQSNSNKTVIIEISGKSQEAVREGRAKLLALVNQFPESKFYKVTIDPLLQRYVIGSKGKNLQKLRNEHQVELLVGEYGEEDPDVIVCYIGADDGKSPDQIQKELADLAESVKSSAEASAKIVSEIIQVPSVYHKHIVGPKGTTLNAIIGKSEENVIVQLGKVSYRPDSTDDDVYIRGFSKDVERVVSEIKQVVRDAKNHEILHSHVEEFDFPAQYSKNVIGKNGSNVSSLREDLGVQINVEEGHIRIQGIKKNVEETAARIKSQIEALIDDTILRVNIPNDFHRQLIGSNGKYVRRLEEKFSVRVRFPREDDSSNSTGNELMKPTSPDEVVIRGGKKSVAAAKQELLELYEYEKSIAYTSTIDIPSKAVSRVVGRNGSTVENIRTQFDVKIDIGDVSTEETTPVSVRGAKADVENAIKEISAIAEEVKNLVEKVIKIDREYHRYLIGPNGSKLQNTIKECGGSTDKTETARLISFSNGNSEEERNSVVLRGDKEIVEALETRLLEIVEELKNQVEEKIEVPQRCISSIIGRMGSTRRDIERKTSTMLNIPNVLDPEETVTITIVGSPENCEKAKEMIQEKVASQYTQMITVPDTVYESIMKGILMKKLRSDLKVFVDTPEIKPVQPTEVVLEDHEDGVFPWKLVTHDYTGSSSSEWAVRGHKENVEKAIASLEKSIKQVMENCIAYLGIPTNLHRRIIGSGGSIINKIRKIAQVKIDVPRTPGDEIVVVQGSRAGVVKAKDLIFERLQENQNQE
The following text describes a protein:
Function:
May be involved in vascular wall and kidney homeostasis.
Subcellular Localization:
Secreted.
Sequence:
MWCGALSIVCLIFLFGISEARKGFGPGEQDWGYVDVRDGAHMFYWLYYTTANVSSYTDRPLVLWLQGGPGGSSTALGNFQELGPVDTNGQPRDGNWVQYVNVLFIDNPVGSGFSYADNTSLLVTNNEELIDDLISFMLHFYKLHKEFKNVPLHIFSESYGGKMAPALAIRLAKAMSAGELAHPGTLKSVTIGNPWISTRHISREHSKYLFVNGLIDEDGVALLDAQEERILSALKKHEFDKATDEYLRWYELMQQLTGEIYLYNTQTHVDPSEDRTYGYGEEFIRFIERNVSEALQINGTVYASQVMEVLSSLHGDRLKSEINTIPRLLNETSVKVNIYSGQLDTLVPTTATLALIKDWAWNDKSEYLEANRTTIVIKGILQGYKKVGGNFGMYWINRSGHMAPSDNPVAMQYVLQSVTQYDSYNIE
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA gene.
Subcellular Localization:
Nucleus.
Sequence:
MGVTILQPYPLPEGKSGAHIIDQLSKRLLALGATHAGQFLVDCETFISTPQPHNGAPGRAVHVLHNSEYPASTFSIIDNGTGKQVAIVADNIFDLLMLKMTNTFTSKKQTKIESRGARFEYGDFVIKLGSVTMMEHFKGILIEIEYKSCVILAYCWEMIREMLQGFLGIAVNKDFPSYFAPQTIMTAMGQQQLHAKHNDIFEPMDTVKQYLEQFTNYRKHVTLMGGMGSGPGSQQVGPNVHMSPAVAGLHRS
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MGSAQSHRTKRNQRKNQKECTNSPETTPPQSSPHENWKQPINKTKKSFTTTQCVSKTVETKPIVPVQEKPTAQIQEKPKTNPQKEETTKITQEKQKEQINTIQNDFNLYQKDGEIQPEGLAQMIEDLGINDVGSIKALWVAWKLGAKDYKINENGFRKGLESVHVSSLKEFKNCIPEDPLNDNLTGKRLFNYAFECNVEYRQKLMEKEDSILLLHQFFGENNEMVNKFITFLSLDSTKPLNRDEWQNLYDFIKTIHLDFSNYDTTSDSAWPLLFDSFVSSFQN
The following text describes a protein:
Function:
Sugar kinase that catalyzes the ATP-dependent phosphorylation of N-acetylmuramate (MurNAc) and N-acetylglucosamine (GlcNAc) at its C1 hydroxyl group, leading to MurNAc alpha-1P and GlcNAc alpha-1P, respectively. Is involved in peptidoglycan recycling as part of a cell wall recycling pathway that bypasses de novo biosynthesis of the peptidoglycan precursor UDP-MurNAc. Plays a role in intrinsic resistance to fosfomycin, which targets the de novo synthesis of UDP-MurNAc. Is also able to use N-acetylgalactosamine (GalNAc) as a substrate, but not N-acetylmannosamine, N-deacetylated sugars or glucose.
Sequence:
MPEHDVRLQQLTVWLDEQLNDLFRDNAWGEVPAGSLTAASSDASFRRYFRWQGAGHSFVIMDAPPPQENCRPFVAIDHLLASADVHVPLIHAQDLERGFLLLGDLGTQTYLDIINADNADGLFADAIDALLKFQRLPMDAPLPSYDDALLRREVELFPEWYVGRELGLTFTDAQKATWQRVSQLLIDSALAQPKVLVHRDYMPRNLMQSTPNPGVLDFQDAVYGPVTYDITCLFKDAFVSWPQARVEGWLGDYWQQAQAAGIPVHAEFEAFHRASDLMGVQRHLKVIGIFARICHRDGKPRYLGDVPRFFAYINEVIGRRPELAELGELIAELQAGARA
The following text describes a protein:
Function:
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similarity).
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MATLGGLTHSHTLFVEDDGTPVRFYIPPGPLKRQLYQLIIHGGGEMCRLQQPGALLLSTPGSAQGAQYVSTAYVMDCVRKGELLHVDDYRLDGSHGRKRQSKGMKQDEREGESSHGSDGKEQVKVGEGPEEEDELSDLGELVIEEGLEEDEQESDTVKIKKENKMDCSEAQKIGSLKSARIHQTGRNPFTEEEDVAILVYVRDNAPHRGTVTGIALWKEMEQRRVLKRTWQAIKDRYIKHLKGKQGYRLPLSAASRSHDPSEDESPQPITKKSRTNTSTPWTKRPGNIGRTSEKLGTALPMEKSSTKAPAEQSDAVESTSINFPLEKRGQHVTKGVVRRSEGEKKSSDMSKGAVSATSKEDQEDGGDLHIFEIANMEFEVDDTPEIELPKRSLSLREFVMGEDPPSSQSQTQVDEVSSSPEDSESEGLQEALLGMMSEFKLRLRDVTQALLKNNGELSATRHFLRTGSRPDGFPIWIRKDDLDLQKADAETQKRLIQKYGSDNVAKRVAFLAS
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
Sequence:
MDSDIPLQDIFSPPRFPRYSPLSSGIRRTSKFSSTTENFDRFIPDRSSTNMDIARCLLTQPRKNKRNKDTIVSPSKEVYRKCLAETILQNRTRILSFKSKPPPKPLDSWLKKPFSHQDKFVKPHRHIPQSADRILDASDIVDDYYLNLIDWGSANILAIALRNTVYLWDDSIGSTSELMTVDEENGPVTSVNWAPDGKHIAVGMNSSDVQLWDSTSNSLLRTFKGAHCSRVGALAWNNQILTTGGMDGMITNNDVRMRSHIVQTYSGHTQEVCGLKWSTSGRLLASGGKDNLLHIWDLSKSSSNIVRNQNQWLHRLDDHVDAVRAIAWCPFQSNLLVSGGNKNDQSIKFWNIHNGTCLNSVSTRSQVCSLLWNKNEKELLSSHGLTNNQITLWKYPSMVKMAELTGHTSRVLFMTQSPNGCTVATAAGDETLRLWNVFGNPDAQKPSSTNSNAITEFFARFNHIR
The following text describes a protein:
Function:
Acts downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. Mediates signaling of the complex.
Sequence:
MATVAPKGNCLVARAIPSDSHADQLTDLLCKLSVNGDANQKSVNKFESQHGVTPSDFRDIQNIRSSALAKKTKTSKFQLDGVTLFADLTPNSKSKKKTENQETKEKDEEAEEKKDGPPKDDKELKMKKEKEQEDENAELDEQKKDGDLLGRGPVHNVRVATGGSHPYHRAQIPYGCAAQTPITDISAYTGYGSGYECGSTWSLSPDTTIGSISASTTPDTVLSSDGYGSASPPQHSPKESLQSPFSDISSADTSRVLTPENNELPESLQDFILQYSNQYTKEESIRGRPPSADSGVSSPMSARSAPYASPHVPQGTCSGPTTPSFNQTRLSPRTSENGITAKQRLNAIIPESDLATGFHWACTTWKNVLTNRDADGDTPLHIVAAHNDLGKIYALCETLRKTMNENDDNVFNVSNNFGETPLYVAVLQRSIEVVEYLLELGASPNSRSSRAVGDSPLHFATARGMNNMVEALLSKREIRVNETNDDGQTSLLCAVKMHGMMDEQTQHKIDNKSIIEMLIKAGADPTIAETSTGKTIVHHAVDKMDVELLDFLKTVVNEDTFTELANLSDFHGDTAVDLLCSSTQNEDTNNVRENLYIRLLTSGAVPNKSRA
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTTIREIWSWNKTEEMNLVRESLRSCNYISVDTEFPGCLKETVMEASEETRYQNLRFNVDKTKPIQLGFSLFDSEGAISGTWEVNFSDFDETEDLCNEKSIAFLKRNGLDFKRIREEGVGIKDFFTEFTRMVKDEEDKKIINWVTFDGSYDLGYIIQSMTGRERLPDTSLGFNDTVQKLLGLTFDVKKLAGQCKGLNSRFGLQRLADELGIRRVGEAHHAGSDSQLTARVFANINLTFSRDLKRKREHEREIVMIRREHDRLQQHLFMQQVMEQEILMRRCVPRRCYGPVHPPRPIMYAHYPSPRGYFVVPVAPRLSRNAQQ
The following text describes a protein:
Function:
Transcriptional activator.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSVFYPIHCTDYLRSAEMTEVIMNTPSMDEIGLSPRKDSYQIFPDPSDFERCCKLKDRLPSIVVEPTEGDVESGELRWPPEEFVVDEDKEITCDQTKKENEQ
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly. May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Nucleus.
Sequence:
MTQKDLEKKFLSRKLSTATAEDLKNEAFRRKIVESSIEIRELESKLKMAYILKERKKQLDEKESIRVMEKVMTLQEREETEKQLKLDHELEIRKLLYEKWKKEKYCQELVKQAEQYRAAKQLELMKERKLDDMYLQEILMAELRRERQEREDRERKKRRLAEELDNCIRLQNQWKAIQKLIEMEEDRLIEECQVQRRRLSHMQQQERKEKADKLAAIRQQLQKALEVEERRRREREELWVEYGCEEREDLETKKAVELEKMTQAQRIKWNEDMTEQLRLLELKKKAMKEEELNERLWMLEQAALEEQAEREAADKRHKDLTQLQKEQAALLEERRQQRKLEFAEKEEERRREEMRQQAEDQAIAEERRRILEQHAPLLIGFMPPGVFRDMAEIRSLPENVQAQFRRHVRIQDDPDLW
The following text describes a protein:
Function:
Histone demethylase that demethylates 'Lys-9' (H3K9me) of histone H3 with a specific activity for H3K9me1 and H3K9me2. No activity on H3K4, H3K27, H3K36, H3R2 and H4R3 methyl marks, but weak activity on H3K9me3. Involved in regulation of gene expression. Regulates flowering time by repressing the major flowering regulator CONSTANS (CO) and promoting FLOWERING LOCUS C (FLC). Exhibits a positive impact on abscisic acid- (ABA), hydrogen peroxide- (H(2)O(2)) and calcium- (Ca(2+)) induced stomatal closure. Promotes stomatal-closure-dependent drought-stress responses through its histone demethylase activity toward at least GOLS2 and RD20 loci, thus protecting them from silencing by removing H3K9me2 marks in drought conditions. Required for plant defenses leading to resistance against the virulent bacterial pathogen Pseudomonas syringae pv. tomato DC3000 (Pst DC3000) via a negative regulation of WRKY25 (a repressor of defense) and by triggering the expression of several pathogenesis-related (PR) proteins (e.g. PR1, PR3, PR4 and PR5).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Mainly observed in the nucleus, but also, to a lower extent, in the cytoplasm.
Sequence:
MEKMRGKRIRPRDSGELVEDGRSESERKTRKKENDVVSKGRIGRGRGRGEVSKRSIEIDISNPEKDIKPDGSRKCLGSTCHHCKILTSESDLIFCSKCNKKCYCFDCIKRSYSERTHEEVRAACPFCMMTCICRACLRLPLVIKPPSEKDTDVKLKQLQYLLVKVLPVLKDIYTEQNRELEIESTIRGHPVTEANIKRCKLDPSERIYCDLCRTSIANFHRSCPNKNCSVDICLSCCKELSEGFHQERDGKKNAEGKGYECRIPAGQGKDSDAYVPLHFSTWKLNSDSSIPCPPKECGGCGTSTLELRRLWKRDWVEKLITNAEKCTLNFRPTDVDIVHECSSCSTNSDSIRRQAAFRKNAHDNFLYSPNAVDLAEDDIAHFQFHWMKAEPVIVRNVLEKTSGLSWEPMVMWRACREMDPKRKGTEEETTKVKALDCLDWCEVEINLHQFFEGYLEGRMHKNGWPEMLKLKDWPPSDLFEKRLPRHNAEFIAALPFFDYTDPKSGILNLATRFPEGSLKPDLGPKTYIAYGFHEELNRGDSVTKLHCDISDAVNVLTHTAKVEIPPVKYQNIKVHQKKYAEAMLQKQQYSGQVKEASELENKSMKEVDESKKDLKDKAANEEQSNNSSRPSGSGEAEKVIISKEDNPTQPAVSTSVESIQEQKLDAPKETDGNTNERSKAVHGGAVWDIFRREDVPKLIQFLKRHEHEFRHFNNEPLESVIHPIHDQTMFLSDSQKKQLKEEFDIEPWTFEQHLGEAVFIPAGCPHQVRNRQSCIKVALDFVAPESVEECLRLTQEFRRLPKDHSSSEDKLELKKIALYAASSAIREVKGLMQSSRRSDT
The following text describes a protein:
Function:
Catalyzes the attachment of a first N-acetyl-N-hydroxylysine to a carboxylic group of citric acid to yield N-citryl-N-acetyl-N-hydroxylysine. Involved in the biosynthesis of the siderophore aerobactin which is a chelator that mediates the high-affinity iron transport systems induced under iron-stressed conditions.
Sequence:
MILPSEKSATDVAAQCFLNALIRETKDWQLAEYPPDELIIPLDEQKSLHFRVAYFSPTQHHRFAFPAHLVTASGSYPVDFTTLSRLIIDKLRHQLFLPVPLCETFHQRVLESYAHTQQTIDARHDWAILREKALNFGEAEQALLTGHAFHPAPKSHEPFNRQEAERYLPDMAPHFPLRWFSVDKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQWLFPLRPWQGEYLFQQVWCQALFAKGLIRDLGEAGTSWLPTTSSRSLYCATSRDMIKFSLSVRLTNSVRTLSVKEVERGMRLARLAQTDGWQMLQARFPTFRVMQEDDWTGLRDLNGNIMQESLFSPAWKTLLLEQPQSQTNVLVSLTQAGPHGGDSLLVSAVKRLSDRLGITVQQAAHAWVDAYCQQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGFIYRDCQGSAFMPHATEWLDTIDEAQAENIFTREQLLRYFPYYLLVNSTFAVTAALGAAGLDSEANLMARVRTLLAEVRDQVTHKTCLNYVLESPYWNVKGNFFCYLNDHNENTIVDPSVIYFDFANPLQAQEV