lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Implicated in development of the cochlea.
Sequence:
MDACRPAEKRSRKPAHPLRRNISEDMKNFAENTMNELLGWYGYDKVDLQDSEAADARNRVKRNHISVLKENAVPKPLNVEKKIPPSSSSSSSSSSSCSSEPVRNGDQDPPTVPVSPSASSASPRHNMNVIVPLIKPSAVEDVQNVQIVCVWCQKEGMKRYSLLMGSELKSFCSEKCFAACRRAYFKRNKARDEDRHGDKSPSPGQTLDTPTRLMLKMNNNNSSTRVCDWCKHIRHTKEYLDFGSGEERLQFCSTKCLNQYKMDVFYREARAALTSSKEEENHPKPAATSENQTLLTPDAWESPAKSLSPQTPTASALQRTPVCMRVQMATSPKSPTGPSQGTPEQPRPPHMPLPFIRPPLHAQSLRSPTPNLPHNPPHPLSPTQRVPFAPPPHYPLPYLPLHPTFPPQMPPPWPQPMMMMPYPVFVPIPIPIPIPIPISPQNSHRGVIRSLQEPEKEPAGSQRVKTERCVSPVSASERQVIQCLRRDSVKEERNDTHIQTLRKALYTSVLTSTASASLDGRIVSPASLYSLARSTAIQAASFSLDSSSGQIPSPLSDCEDVKENSYLCGRGNDSANQWTAEQMDCQSDQSKEGKGEEETPQDVEHTYARSVPPKLREKNTHVNTQTHLHTQIWEKNTQVDELGPEQSVRDDAEPAVKRRCLRIRDQNK
The following text describes a protein:
Function:
As part of MIA, a complex associated with the outer doublet microtubules of the axoneme, may play a role in ciliary/flagellar motility by regulating the assembly and the activity of inner dynein arm.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Note=Localizes to the outer doublet microtubules of the axoneme.
Sequence:
MDEEGSATARAKMMPQTLVLDHVSPATRLLEKRRQMFEVQEALEAQKQDFNRKEEVFKRREEALKLKDLELQESLIRFSKFLQENDSKRARAEKKANDEIKARIQKEKEIEQLTEVLEELKSEKERILEVLEKNMRYQHYLESVLEVADEYQEVADLLLRHATLSATNADLKDHQRKCSELAEKVRTELQIYVKQKTDEILNLNNQVAKLKTELEGYEAEAMVQEAKKDSSLQIASQRTLEYGQVVLSADNIFNRCRSKSSIGHPAESNPLHQLDVIGNFVSDLGSIIKQFKQEQAKRASLASRAEIE
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDYRGQIRAGHLMRLIIILFALFGLLTAWAFKNMGIGLLVHAFGLCLAALATVPDWPYYNQMEIAWQPVRGRTERLTVFQRLLSIFQ
The following text describes a protein:
Function:
Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression (By similarity). Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser- 536' (By similarity). May be involved in early neuronal development (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MDFQQLADVAEKWCSSTPFELIAAEETERRMDFYADPGVSFYVLCPDNGCGDSFHVWSESEDCLPFLQLAQDYISSCGKKTLQEVLEKVFKSFRPLLGLPDADDDAFEEYSADVEEEEPEADHPQMGVSQQ
The following text describes a protein:
Function:
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Subcellular Localization:
Nucleus.
Sequence:
MNQSQSQQTSEGRHEDDTALADFLASLMDYTPTIPDELVEHYLGKSGFQCPDVRLIRLVAVATQKFIADVATDALQHCKARQSAVVKDKRDKQQKDKRLILTMDDLSKSLREYGVNVKHQEYFADSPSAGLDPASREE
The following text describes a protein:
Function:
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAFEGVLQIVATLVLMVAIVPFFGTYMARVFQGESTWLDRVLGPIENLVYRLGGVRPELTMDWWSYARAVLASNAAMFVPVFAVLLLQGSLPLNPNGISGMSWDLALHTAISFLTNTNQQHYSGETGASHLAQMVCFQFLMFTSAATGLAVGIAFIRGLLGKPLGNFYVDLTRSVSRILMPISIAFAVVLLSQGVPQSLGGTTEAQLVDPYRTEQDGKREQVTAQKLVSGPFASMESIKELGENGGGSYGINSAHPYENPNPFTNLLEILLLLAVPTSLIYTFGVLANNKKQGWVLFGTIFVLFVGLVGVAALGEYWGNPTVNALLGSANPNFEGQEVRFGWAQSALFATATTGTMTGAVNAMHDSLTPLAGLVTLFNLCLQVIWGGQGTGIAYILVFLIIAVFLTGLMVGRTPEIFGRKLEKREVALASIIFLVHPVIILVPTAIALAIPGLAGNSNPGFHGLTQVVYEYASAAANNGSGFEGLGDATPWWNLSTSVVLLLGRYAPIVALLALAGGLQRKQPVPETPGTLRTDTVLFGSVTAGTILILGALTFFPVFALGPIAEWIANLAGKTL
The following text describes a protein:
Function:
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MRKKVDDRIRTLIENGVKTRHRSMFVIVGDKSRDQIVNLHYMLSKAVVRSRPTVLWCYKDKLELSSHKKKRAKQIKKLMQRGLLDPEKVDPFSLFVESGGLTYCLYKDSERILGNTFGMCILQDFEALTPNLLARMIETVEGGGLVVLLVRSLSSLTSLYTMVMDVHERFRTESHSEAAGRFNERFLLSLASCKACAVMDDELNILPISSHIRSITPVPVIEDSEGLSETQRDLKNLKEQLSDDFPVGPLIRKCCTLDQGKAVITFLDSILDKALRSTVALLAARGRGKSAALGLAIAGAIAAGYSNIFVTAPSPENLKTLFDFVCKGFDALEYKEHIDYDVVKSANPEFKKATVRINIYKQHRQTIQYIQPQEHEKLSQVELLVVDEAAAIPLPVVKSLLGPYLVFLSSTVNGYEGTGRSLSLKLLQQLEEQSQMGTKSMDGSLSGRVFKKVELSESIRYASGDPIESWLNGLLCLDVTSSIPNISRLPPPSECDLYYVNRDTLFSYHKDSELFLQRMMALYVASHYKNSPNDLQLMADAPAHHLFVLLGPVDESKNHLPDILCVIQVCLEGQISRNSALRSLSDGHQPFGDQIPWKFCEQFQDTVFPSLSGARIVRIAVHPSAMRLGYGSTAVELLTRYYEGELTPISEADPDKVVEKTNVRVTEAAEKVSLLEENIKPRSNLPHLLVHLHERPPEKLHYIGVSFGLTQDLFRFWRKHKFAPFYIGQIPNTVTGEHTCMTLKPLNNDDIEASGSDQWGFFSPFYQDFRRRFTRLLGSSFRAMEYKLAMSVLDPKINFTEQEPMPFTSNGFSRSLNDILSPYDMKRLEAYTNNLADFHMILDLVPILTYQYFQEKLPVTLSYAQASVLLCMGLQCQTVTYIEGAMKLERQQILSLFIKVMKKFHKYLFSIASEEIHANLPRIKEVVMEPHSVSVDDDLNDAAKQVKDKMKAETEDLLNPEFLQQYAIVDREDDFENALQNGAGKISSSGLISVKSSKNKVGKHGKLSENNKDTKKRGKGDGGFKSNKKKKS
The following text describes a protein:
Function:
Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
Sequence:
MLNPSIDSLLQKIDSKYTLVTVAAKRAREMQLANNCVVEKPVSHKCVGKALEEIDAEALSYVPSEDKVAE
The following text describes a protein:
Function:
Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate. The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate. This enzyme participates in both the breakdown and synthesis of glucose. Enzyme of the glycolytic pathway (Probable). Glycolysis is essential in glial cells but not in neurons; neurons rely on the citric acid cycle for their energy needs, and on lactate and alanine secreted into the hemolymph by glial cells to fuel it.
Sequence:
MSLTVEIVATKPYEGQKPGTSGLRKKVKVFTQPNYTENFVQAILEANGAALAGSTLVVGGDGRFYCKEAAELIVRLSAANGVSKLLVGQNGILSTPAVSSLIRHNKALGGIVLTASHNPGGPENDFGIKFNCENGGPAPDAFTNHIYKITTEIKEYKLVRNLQIDISKVGVTSFDIAGKPFTVEVIDSVANYVRHMEEIFDFAKLKDFVSGKATGKPLKMRIDAMNGVTGSYVREIFLNRLGATESSVVHTTPLPDFGGLHPDPNLTYAKDLVDTVAQGDYDIGAAFDGDGDRNMIIGSKAFFVTPSDSLAVIAHYLEAIPYFQKNGVQGFARSMPTASAVDLVGRKLGKEVFEVPTGWKYFGNLMDAGRLCLCGEESFGTGSNHIREKDGIWAVLAWISVMQHTGKGIEDILKQHWSVYGRNYFTRYDYEECASDPCNEMVATMEKTITAPEFVGKSYSSGGKTYKVKEADNFSYTDPVDKSVATKQGLRIVFEDGSRIVVRLSGTGSSGATVRLYIDSYEKENVLGQASVMLKPLIDIALEISQLPKFTGRNAPTVIT
The following text describes a protein:
Function:
Transcriptional activator.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNNLVEGSLNNQPRRQTTGKYDDHGNSNGSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPIICSLNTDKKEWAKWTKEELIGQLKPMFHGIKWTCNNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGNLGAGSSVHHKCNSAKHRIISPKVEPRTGGYSTHSEVQNNDVSEGKNEHSHGKSSSREKRNGKMAKPVLLHQNSTEVSSTNQVEVPDTTQNSPVSISSGLNSDPDMADSPAVTGVSSMAVASVMGSLSQNATVFMSEVTNEAVYSMSPNTGPNQHLLSSDTSAQGLVLAVSSDGHKFAFPTTGSSDSLSMLSANVAEELVLSTTLDSSRKIPETAMNFDPDCFLNNPKQGQTYGGGGLKEDNICSNMRRSSSTDRSFGFNAVLAKEIKTEDTSFEQQLAKESFPSTSSNTLTLTPGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYTTSFNHAVQSPHVHQTPSPSFFLQDASKPIPLDQNSHNSLNDTNSTYVNTLEIPNVKTEVSSQTASNCNGTIDQARIESTSSLQLMQFQANYQAMTAEEVPMETSQQTEGNDGLLKQADLQACSAEHYMQSDNNAGMRNGGSLPILQGNMVQGLYPVAHQTINNSSNMELNLDHFDISFSNQFSDLINDFISVEGGGNTIYGHQLVAGDNNVLPQSEDGSRPAYSQAEMCIPCCSPQQASMQLSGADTGVTTMAYMHVAEVVSAAAAAQSTLGMLQQSGRLFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAYNSQILSNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMTGAQQHKQSVGGGNGGGANSGGNQAQCAAGTGSIGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHTEAAVVLYKWDRRAISIPDSLGRLPLSIARSRGHVKLAECLEQLQREEHSQMGQNPRIQCSPSEDTSADSWLTQWQSDTMSHSQESQKGVTIISNVNTELRRPRSEPANYYSSENPKDYPAAKKHKLNPEYFQGRQERVISTALSLEQPSTRKQCSSTKQSLPEALSHNEGMRDFSRDLPPRTPDTSSYKATTGLKWKPKDLYLGVSAVQLTGTPKTSALGKDIVGHKLRQREQMNVLMMSEREMVDAELLSYRENLENEDCLQHMDDLQVNMMNLAEQIIEATPERIKRENFVPMESSLAERADSAAFSTTMSWLASYLADVDHLPSAAQIRSLYNEPLTPSSNTSLSPACSPLNQTTFEKPSLPSAADWSEFLSASNNEKVENEFAQLTLSDHEQRELYEAAKLVQTVFRKYKGRPLREQQEVAAAVIQRCYRKYKQLTWIALKYALYKKMTQAAILIQSKFRSYYEQKKFQQSRRAAVLIQQYYRSYKECGKMRQRRRTASLVQQKLRSSLLTKKQDQAARKIMRFLRRCRHSPLVDHRLYKRSERIEKGQGT
The following text describes a protein:
Function:
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Domain:
Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
Sequence:
MIPSDFIDELLAKTDIVDIIDEQVPLKKGGANYMACCPFHKEKTPSFSVSPTKQFYHCFSCGAHGSAIGFVMEHQGLSFPEAVQFLADRVGMVVPKVHGQNDNPEVRAERKKKQQTLEETTAAAADFYAQQLKFNPAAKAYLDKRGLSAEVIAHYGLGYAPDGWQPLTQVFQPYPNTALVDTGMVIDNEGRHYDRFRHRIMFPIRNPRGQVIGFGGRVLDDSKPKYLNSPDTPLFDKGKNLYGLYEGRAAVKEAGRILVVEGYMDVVALAQFGVGYGVAALGTATTAEHVKILMRQADSIYFCFDGDSAGRKAAWRALENALPQLKDDKSLHFLFLPEEHDPDSYIRAYGKAQFEDALLNQSKPLSEYFWEHLSDGIHLNTQEGKAELVKTSSPLLAQITAPALAYLLKQRLSELVGIDPDNLAQLLGQEAPKRHVKQKNYKLPPISVKQPVMLTLVQRQIRSLLINPDWAAYIDLPDYLALDGDFACLANLAESIKNHAAVPETAQVLEYMRGSPYEETITRIFHSTHQSEEMNSSSEEDCENFQIGMKKLLNELKYSQIETLKQKSLQSGLNESEKKLLLSLLTAKQN
The following text describes a protein:
Function:
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MSTSWDNARRHARALETALDSKLSTYSKLAASIARGSSLGGSSSRDELSMEEEGIGGYKLVEEEIEELLSKLEQAIEDLTSLINSPSQPPSTSMQHSAQTHRDNLDDYRRDFVRTRNNVEQTIRRSNLLGSVRKDISDYKSGRSGTTDALLQDRSRIDSSHRMIDDTLNQAYATREDFAQQRTFLASIDSRMGGVLNQMPGINSLITMIRTRRRRDTVIMGCVIGLCVVLLLGYMFGF
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MADQLRTLPKNAKVIYEHCLKQIPNSLSQQDLVEAIGASISVNDLSSALNILLSRRLLDPLRQGNVLVYRAVRLDEAKTVSTMEGDEQIVYSFIKNSGNEGIWRKTLTLRTNLHVSVVDRCLKSLESKNLVKSIKSVKNPTRKIYMLYDLVPSTELTGGPWFTDQELDVEFIENLKKVIYRYVHSKSFPPKKAAMGPDLVWGPEYNGYPTALQIHNWLRSTNITKVDLSLANVISLVDVLIYDGKVEKRSDGASYRAIRVNNENIDAFTESPCGNCPVSDICDANSRVNPITCEYLDKWLN
The following text describes a protein:
Function:
May be involved in the generation of 28S rRNA.
Subcellular Localization:
Nucleus.
Sequence:
MEEETKVVKKVTGPAKPQKLRSIDVELAQKLNTGSSQTKSSALYKLRSVVKNEKLTEIQLLKIWKGLFLSLYNTDKPIVQEEFSRDISKLTTYFKDYKDSLMFIKCFFIILQKHWDYIDKYRVDKFYSLVRKMLNSSFQILKKRNAQHEEGSEEEEARLALNEQIYSGLVKIFKSTVLNTSSDSTTNTNGVLLHFADIYLEELFKVTQGHMEPINLTKILLPFVNFLTKSEDDVSCKRIKERVFDRLLTTYSPFDKKDAYYLPKVGVSSSTPEIFPTDYEMFSKLFFKCASSKDTLEQNRKTLYGLKNQFKRAQAALEELEELADNIVLDENGDIVENPNVNPEDLQGDDSDDSDEEFDVDQMDSEDSGEGEFDDEIDADDAEELDDDDDEEFDEELDEEDEEEEEEEEEEVPPPPPTKNLKSKPSPVTQKNKQQQQQPPAKPAPITKKQQQSPAKPTQVTKKQQSPAKPTPVTKKQQSPVKPTSPKVVKKPTRK
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center.
Sequence:
MESMTPRWNQDRPGRFHKETRTSSKLADSKWFPSNSSSNSGVEQAIGCYDTPVQELIVIDDLLSALLLLNTLNLPMMGSMRALAAVIQQASAKHFVGSGVLNLLHNQAKAMAGDNSVRSLLEKMTECASNAYLSILERWVYEGIIDDPYGEFFIAENRSLKKESLSQDSTAKYWSQRYSLKETIPGFLANIAATILTTGKYLNVMRECGHNVQVPISERSKLTIFGSNHHYLECIKAAHEFASKELVSLIMDKYGLIGRLRSIKHYLLLDQGDFLVHFMDIAREELNKKVNEISVQKLQVSLLPLFNHLALRTTASAADPRHEDLTCFVDRTSLLTTLGMDKDPDSNSVEDPVSITGLETFSLSYKVQWPLSIVISKKALSKYQLIFRFLFHCKHVERQLCGAWQIHQGIRSMNSNGTAICRSSLLCRSMLKFISSLLHYLTFEVLEPNWHVMQDGLQSTRSIDEVIQHHDFFLDKCLRGCFLLLPDVLKVSKLKSVCLQYAAATQWLISSSVDINSQSQKTMIRDTTVTESIFNFEREFNSELQSLGPVLSKGSQAEPYLTHLSQCILGVSKD
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MIDSGEKKPGRRAEEAVTFKDVAVIFTEEELGLLDPAQRKLYRDVMLENFRNLLSVGHQPFHGDTFHFLREEKFWVMGKTNQREGNSGGKIQTEMETVPEAGTHEEFSCKQIWEQIASDLTRSQDTTISNSQLFEQDDSPSQIKARLSTVHTREKPFQGEKCKQSFSDVSIFDLPQQLYSGEKSHTCDECGKSFCYISALHIHQRVHMGVKCYKCDVCGKEFSQSSRLQTHQRVHTGEKPFKCEQCGKGFRCRSALKVHCKLHMREKPYNCEKCGKAFMHNFQLQKHQRIHTGEKPFKCEICGKSFCLRSSLNRHCMVHTAEKLYKSEEYGRDFIDRLDLHKHQMIHMGQKPYNCKECGKSFKWSSYLLVHQRVHTGEKPYKCEECGKGYISKSGLDFHHRTHTGERSYNCDNCGKSFRHASSILNHKKLHCQRKPLKCEDCGKRLVCQSYCKDQQRDHSGENPSKCEDCGKRYKRRLNLDIILSLFLNDI
The following text describes a protein:
Function:
Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.
Subcellular Localization:
Apical cell membrane; Lipid-anchor, GPI-anchor. Membrane; Lipid-anchor, GPI-anchor.
Sequence:
MWRQVLVALCLSLWICSSDLTLAEDPYLIRAYQLMSETPLIDGHNDLPWQLRMQFNNQLNKVNLDTLETTHTNIPKIKEGRLGAQFWAAYVPCETQYKDAVRQTLEQIDVVHRMCEKYPDTFKFVTTSQGIMDAFKENKTASLIGVEGGHSIDSSLGTLRTMYQLGVRYLTLTHSCNTPWADNWRVDDGSDPVQSGGLSPFGKQLIVEMNRLGMLIDLAHVPVSVMKQTLSLSVAPVIFSHSSAYAVCRHSRNVPDEVLLKVKEKKGIVMVNFYNDYVTCSQKANISDVADHFDHIKKVGGAEIIGFGGDYDGVPRTPEGLEDVSKVPNLVAELLRRGWTDEEVKAALGNNLLRVMSEVERVRDNMTSRAPDDVPIPYSEVENPCRTSFGYTDAGAAHSVSTAALLLPLALHISMFTN
The following text describes a protein:
Function:
Probable promoter-specific protein mediating the interaction between DNA and RNA polymerase.
Sequence:
MVGNLDNRKEKILVVDDEASIRRILETRLSMIGYDVVTAADGEEALEVFSREHPDLVVLDVMMPKLDGYGVCQELRKDSDVPIIMLTALGDVADRITGLELGADDYVVKPFSPKELEARIRSVLRRADRDTASGIPSSGVIHVGDLKIDTNKRQVYKRGERIRLTGMEFSLLELVVSRSGEPFSRSEILQEVWGYTPERHVDTRVVDVHISRLRSKLEDDPSNPELILTARGTGYLFQRITEPKE
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MISRSALSRGSQLALRRPAAAKTAQRGFAAAAASPAASYEPTTIAGVKVASRDDSGPTTRLAVVAKAGTRYEPLPGLTVGLEEFAFKNTNKRTALRITRESELLGGQLQAYHTREAVVLQASFLREDLPYFTELLAEVISETKYTTHEFHELVENCIHEKQAKLDSAAIALDAAHNVAFHSGLGSPLYPTVDTPTSSYLNENSVAAFANLAYNKANIAVVADGASQAGLEKWVEPFFKGVPATSSGNLNTAASKYFGGEQRVAKNGKNAIVIAFPGASLGVPHPETSVLVGLLGGVSNIKWSPGFSLLAKATAANPGAEAFAHNYAYSDAGLLAIQITGKGAAVGKVAVEAVKGLKAIAAGGVSKEDLTKAIAKAKFNLLSASEVSGTGLVHAGANLLAGGKPIQVAETLKALEGVTAEKLQAAAKKLLEGKASVSAVGDLHVLPYAEDLGLKV
The following text describes a protein:
Function:
Involved in the synthesis of fatty acids. Elongates C20 polyunsaturated fatty acids (PUFAs) with a preference for n-6 PUFAs.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKFADAMQCIGKESLCFHPELNVFVNYPVLIGCHIGYLVVIVLLYKFMKGRTAYVLKYPMMLYNTAQVALSLVMAINLGQFLVYGVFNLNGGFTGTIEYWIFVHYATKFLDMFDTYFIVLRKKEEQLSFLHIYHHVTIGFIWGLLLHHGVANGTAFFGAWINSAVHALMYFHYLYTSLGYTNPLKTYLTQLQMIQFALCILHAVLAVVAHSPIPKKWAVLQLCYHLTLLYLFMRFYRKGMRKLKRKAKV
The following text describes a protein:
Function:
May negatively regulate the SNF1 kinase by promoting the interaction of the REG1/GLC7 phosphatase complex with the kinase. Deletion of SIP5 promotes resistance to artemisinin, which is probably an indirect effect of an action on the electron transport chain.
Miscellaneous:
MISCELLANEOUS: Present with 556 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MGNVPGKIDQEDSFNDVRPDSSYNTTSSNSVIKQYDEEASSRVRTRRTTSLVNNILNGNNARTKTGSHLSSTSRRKTSREKELAKEAHAKQLVVRCSETVDGGFLAPFGCYSFEKLDYDATVVKNLIIKRKLAPFYTPLQDFDESWTRDELIKIVDGLPLHDTFDENLEEFEDVPIGNLRKSTFNELIDKSLSKKEQRRMHAKIFRARLYKKRILWQENENETFLERKLEMKRIGSKSSNVEDNTSSQPRKNYHLPSDDLKYTLYKNGSECPICFLYFPGPFNYSKCCQQPICTECFVQIKRADPHFPHDEVDPTEPQTNDSEKDPNLLTSEPANCPYCATASFSITYQPPTNRETGIGGMPADSYVYKDAAISRADGGQPNISAITSDTIRPDWEIKLNKERARLMRRSANATAIHISNRLIDPSHSRRRNTSHSITPIHDESTSASRSPEPTINELEDQMVREAIRLSLEDQDNRKKSKNRNTSLRP
The following text describes a protein:
Function:
Probable transcriptional regulator. May mediate transcriptional activation by binding to the E-box motif 5'-CANNTG-3'. Plays a role in the differentiation of the hermaphrodite-specific motor neurons (HSN) that are required for normal egg laying. Might play a role in serotonin production by regulating expression of the tryptophan hydrolase tph-1 which catalyzes serotonin synthesis, in the HSN neurons. Also plays a role in HSN axon guidance towards the vulva and the ventral nerve cord, possibly by promoting the expression of the netrin receptor unc-40. Under feeding conditions, involved in the regulation of the srh-234 chemoreceptor encoding gene expression in the ADL sensory neurons. Together with hlh-2, involved in the induction of programmed cell death in the sister cells of the serotonergic neurosecretory motor (NSM) neurons, probably through the activation of egl-1 transcription.
Subcellular Localization:
Nucleus.
Sequence:
MTASTSSTPSTSTKIPSSSKSSVTKQTKQKRNERERKRVDQVNQGFVLLQERVPKAAGNKAKLSKVETLREAARYIQELQKQLGMSSTSFHNSMPADFPTPEQSPVYPQSVCSMMAQTPSPSYTSPYYPPPQMMSSNQHDMSSHYYQESSSSSASTSGDHHSFYSHTETY
The following text describes a protein:
Function:
Could act as an H1-type linker histone.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MPPKKASTGATKKATSSHASYRDMIKDAILNLKERNGSSRQSIKKYVLANNKIAFASQAAFDSQFNKAIKAGVEKGEFTQPKGPSGPVKLAKKEPAAKPAAKKATTATKAAAPKKAAAKKTEKAEKPAAKATTKKAGTTTKKAAGRPKANTAKPRKASTAAPAVVDQPKVLSTTKSGRVTKTTAKPAEKATKKKATTTKKAEKSEA
The following text describes a protein:
Function:
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Subcellular Localization:
Secreted. Melanosome.
Domain:
The N-terminal (AA 42-139) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 380-416) is essential for serpin activity.
Sequence:
MQALVLLLWTGALLGFGRCQNAGQEAGSLTPESTGAPVEEEDPFFKVPVNKLAAAVSNFGYDLYRVRSGESPTANVLLSPLSVATALSALSLGAEQRTESNIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASRIIFERKLRIKASFIPPLEKSYGTRPRILTGNSRVDLQEINNWVQAQMKGKVARSTREMPSEISIFLLGVAYFKGQWVTKFDSRKTSLEDFYLDEERTVKVPMMSDPQAVLRYGLDSDLNCKIAQLPLTGSTSIIFFLPQKVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTIPKLKLSYEGELTKSVQELKLQSLFDAPDFSKITGKPIKLTQVEHRVGFEWNEDGAGTNSSPGVQPARLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGT
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MYKTTGLTHLINSTKYSLQGLKSAFKNETAFRHECFLACILIPLTFFLGETKIEIILMISSVLLVMALELLNSAVETVVDRIGTERHELSGRAKDQGSASVFIALCIVGIVWGGILFF
The following text describes a protein:
Function:
Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Early endosome. Membrane; Multi-pass membrane protein.
Sequence:
MAPVFLRLSVFFFCYWVFCFGCCAASARHAVFCLCWAGVACVVWVLGGVFTGGYVHRVSDLTFGVDLKQIRLMGILQRENIVNSGSYMLYAETCYPPLVQYVTYNRLGPIRTMGCPSYYVPPLPCMCTGFDRDPYQFQSTPLIPFGFFGDENASGCSVMWCLTPSNTVIVSPIYYVMFTTLAIIATVIMFKVPFSTIMSEICSFIVVLSGTIMLHLTKDFERSHSFRGGGLPSSPTLSVRFYTGNEDSLLKEDEENKSPEDMCSRRQDLC
The following text describes a protein:
Function:
Required for efficient mating. Involved in the production of alpha-factor, the KAR9 and TUB1 location to the shmoo tip and nuclear migration into pheromone-induced shmoos.
Miscellaneous:
MISCELLANEOUS: Present with 6510 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Note=Detected in both cytosol and nucleus but is predominantly cytosolic.
Sequence:
MSTSASGPEHEFVSKFLTLATLTEPKLPKSYTKPLKDVTNLGVPLPTLKYKYKQNRAKKLKLHQDQQGQDNAAVHLTLKKIQAPKFSIEHDFSPSDTILQIKQHLISEEKASHISEIKLLLKGKVLHDNLFLSDLKVTPANSTITVMIKPNPTISKEPEAEKSTNSPAPAPPQELTVPWDDIEALLKNNFENDQAAVRQVMERLQKGWSLAK
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Acts as an mRNA and 23S rRNA interferase, cleaving predominantly after the first 2 Us in the sequence 5'-UUCCU-3'; in 23S rRNA only cleaves once in the ribosomal A site in dissociated but not intact ribosomes. Cleavage of 23S rRNA inhibits protein translation; the 23S rRNA region cleaved is involved in tRNA-binding in the A site, 30S and 50S subunit interaction and ribosome recycling factor association. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. It dramatically increases persister cell formation in M.smegmatis upon challenge with gentamicin or kanamycin. Overexpression leads to bacteriostasis rather than bacteriocide. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE3.
Sequence:
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNTQTIPVCDLGRQIGYLLASQEPALAEAIGNAFDLDWVVA
The following text describes a protein:
Function:
May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1.
Subcellular Localization:
Nucleus.
Sequence:
MADWLFYQPKVPKRQAKPSSDDGYWDCSVCTFKNTAEAFKCMMCDVRKGTSTRKPRPVSQLVSQQVTQQFASATLPKKEKKEKTEKDKNEREPTLKKNNHKKMRPRLKNVDRSSAQHLEVTVGDLTVIITDYKEKTKPSSSSSSSATSADHHSQSGSNSDNTEKGISRSSSPRGEVSSLNGESH
The following text describes a protein:
Function:
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments (By similarity). Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle. Melanosome. Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments.
Sequence:
MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEDRLSEMKQRLAEENSKCSILSKHQKFVERCCMRCCSPFTFLVNARRRCGECKFSVCKSCCSYQKHEKLWVCCVCQQARLLRTQSLEWFYNNVKTRFKRFGSAKVLKNLYKKHRLESGACFDILGGGLYEPNLENEGSISGSDSTFYRQSEGHSMMDTLAVALQVAEEAIEEAISKAESQRDSLDKQNEASYLRDHRQELAEELAGTILQRIIRKQKDKADLHAEEEEPECTRPQSSGVKARGEGTAAPPGRHKARAALWRSQSAFSFTTEDTLKTSSAEAAPRQPKDRAQRLLEESALPSWRSMDGLDGKNLVPLLQSPDGNWMTLKDSSRQPPTRLLAKPKSRTFQALEVASSVASAYDELGSDSEEDFDYSEALSKLRPPSQGRLKQPQPQPAQAQSSGQGPLATSPSNPEAMCSDSETSSTSSSREAGCRAKLLWLQRKAPKNPSAEKTHLQGELDVNFNPQAAGGETSDSSDPEETLHTADRRARRWRRARVGPEESNRGLPSPSAYPPALHTAQVSDNVSETDISNEAQNSRSSTDSAEEKLRNRLYELAMKMSEKETSSGEDQESESKTEPKNQKGSLSSEENNQGVQEELKKKCSAVSLCNISTEVLKVINATEELIAESAGPWEIPPVSTDRDNGMFPLGTDQRSLDKQLTSLEENVYLAAGTVYGLEGQLSELEDAARCIHSSTGETELADLEDQVAAAAAQVHHAELQISDIESRISALTIAGLNIAPCVRLTRRRDQKQRSQVQTIDTSRQQRRKLPAPPVKAEKIEASSVTPIKTFNRNFLLQGSSTNRPTASTSNTKDLMEPVLESAVMY