lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting.
Subcellular Localization:
Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Mitochondrion membrane; Single-pass type II membrane protein.
Sequence:
MKQNLFTLKNQSKGVTVSDSGFWMILDKRCYICTRNHWGKIFPEHPPSINLEFLHSFRCKRLKRHVILEHADQEDYSFSYFSRGKPGPQPSILMLHGFSFNKDIWLDTLEVLFPHDLHVVCVDMPGHGDTTRLLQESYTATAQTRRIHQFVEWIGLNKSPFHLVGMSMGGMVAGLYAAEYPSEICALSLLCPAGLRYPTESEFFVFLKELVFSKDPSDSTIVSVDEKEGEKLLQICLYDPSFIKTQVRYFTLKLCFLTEKGFLDVSSARSRYSFHDNLRKIKAPTQIIWGKHDKVRDGLENCGAGNSGLPEVAGLLIPESIANCAKGEGPWETVW
The following text describes a protein:
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Sequence:
MAAVSEITERTGQIAIDPSSQAPATKPITGFSGPFKTRLDQIYQSLTTESSNFSRDIQRDDQDPKDNNPLSSLAAFHAYMASPSASALRPAGPPDDSAPITDYFISSSHNTYLTGNQLYSDAAAKAYTDVLLGGCRCVEIDPKVLHGHTLTKGTTFREVCYAIRDSAFIVSDLPVIVSLEVHASLEQQETMVEIMEDAFDGMLIQVTPEMEAMETPPPLRDLKRKILVKVKWVSPSAENAEDVDDRTDDLEQLAPTKSAGASSQSASQAAQKPSKILHSLSRHAIFTKGFSFKQFSQPEAKVPGHVFSLSERAARQADEKYGKELFEHNRKYFMRVYPYGLRVNSSNLDPTFFWRRGAQIVALNWQNSDKGMMLNQGMFAGEQGWILKPQGYRSTEPESAPIPRRTVDLSIEVLAGQDLTLPPGDKNEKGFRPYVACYVHVETPEDAANPGLKGDDSTDSEKTSYKRVTKAGEGVNPDFGSQILQFPTLPGVVEELTFVRFKVKDDEIGFDSLASWACIRLTRLQEGYRVLRLYKCDGSDSGGFLLVRITKNIS
The following text describes a protein:
Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm.
Sequence:
MNLVLPGQVVARGAPNGEGTVKRGDYIISTRTGIFDPEKNSVTYPRKVEETAVLPNVGSIVLARVSRINARQATVNISVVDDVCTKDEFQGVIHVQDIRATEKNKVKVQNSFRPGDIVRALVISLGDGSSYFLTTARNDLGVIFAQSSETGEQMFPVDYQHMQTKSGYTEMRKCAKPILDE
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDILGLVDQAQIRAPQDRRRFECGYDPVSCRKAFARRSDLIRHERIHNNERPFQCQQCGKAFIQRSALTVHFRVHTGERPHVCQTDGCQKAFSDSSSLARHKRVHTGNRPYRCTIEGCSKSFCRRTTLTKHVQRNHVGLSSGNQSSTGHPPTTTVIHGGRGEDSSPVDGCGGGAQMAGVRLSAGSESPCSVGFIDTPGADQYTPPTSILEPVWLYSLLESPDHPAASPNHDPARICQPRFNRVEYGYKQPTNSKTPDSDSFITELSQLYDRSLAGPVVGPLIHASSQSDHSGGACAQDARSHGCTNQMGETDLIWGFIPNVGQSQRKDGPPEHAIFERGGQEGPGRHENGDVPDIHDPRQIFASLSRYSWPSYELHSPAHEPGSLLDPETRSNPPLVGAPLSRDPLSHLPLNLY
The following text describes a protein:
Function:
Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP.
Sequence:
MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ
The following text describes a protein:
Function:
May be involved in the cellular control mechanism of the secretion of toxins from the gland into the venom.
Sequence:
MAHRFTPEQLVEYKEAFSLFDKDGDGAVTTAELGIVLRSLGHNPTEVQLQAIVQDVDANHSGKVDFNEFLVLVAKNTKSYEEEEEEIREAFRVFDKNGNGYITVGELRHVMTNLGEKLTDEEVDQMIKDADLDGDGKVNYEEFVQVMTEK
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MEARSFTIPSCSRLFFALTVLLLISNINPTLAGTSTTAKSNSLKIYKNFIKTSCNSTLYPALCYKYLSSHASTIKTDSVKLCNTALTVNLKAANKTSALVTSMAKKGGLRPAEKAVIEDCNEEIDDCVDELRKASNVLDNLRDALNKEDQMADIKTWVSAAMTDEDTCMDEFEENNVRESVKNKIKKSIVDLRKITSNSLALINRLSN
The following text describes a protein:
Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Sequence:
MDDEWPSELSITDLPSPTLGLSYISPGARVVSPVTALAHDLEVSCRSHSLTPKRRLSLSSAVGNDSYVDDGFSDTTPGQLPDASKTFEFNKENITNNPIALTDDELIAINSRKSACPNDANGPPKLTDSVIFENNSYDNKQSDKVQFPKPWPPRRKSNKENAAIQSGICRQKSAPPTLSNNRHPSTRESSSSDICNKDIMKIWHGTEQTNAEEDDDDAFFDEFEPQHLPDNGSVINERSSSKMEDLMIKQIILSHSSEAEPGTFSKEMQKMKEKYDSKALSASWNGIKPVIDNFERTKRSEPPRGSSPVAIKRSKSQVMSPCKKTTSRLIPRSISCHTFAEPPVIDYGNLGKISPTRYALPKCMGPKCDLRNISPATLAELIRGGYRTDLDEFIIVDCRYPYEYKGGHIKGAINIHTSDGIETRFLSKTDTYHNKKVAVIFHCEFSSKRGPHLCHYLRKRDRNIHADSYPSLYYPELYLLCGGYTAFFEEFKELCEPQNHVKMCDKNYAEELKHFMRKSKTWSGESSKRRRLYTNFGE
The following text describes a protein:
Function:
May mediate the cellular interaction between myeloid cells and B-cells.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The second EGF domain mediates the interaction with the putative ligand.
Sequence:
MLMGATRDMGSRCLLHASVPGMLLIWSILQMMNISASCPQCNENASCFNSTHCVCKEGFWTGSENRRIIEPHEKCQDINECLLKELVCKDVSYCRNKIGTYICSCVVKYPLFNWVAGIINIDHPDCYVNKSKNTGSKTHTLGVLSEFKSKEEVAKGATKLLRKVEHHILNENSDIPKKDENPLLDIVYETKRCKTMTLLEAGNNTMKVDCTSGFKEHNSGGETAVAFIAYKSLGNLLNGSFFSNEEGFQEVTLNSHIVSGAIRSEVKPVLSEPVLLTLQNIQPIDSRAEHLCVHWEGSEEGGSWSTKGCSHVYTNNSYTICKCFHLSSFAVLMALPHEEDGVLSALSVITYVGLSLSLLCLFLAAITFLLCRPIQNTSTTLHLQLSICLFLADLLFLTGINRTKPKVLCSIIAGMLHYLYLASFMWMFLEGLHLFLTVSNLKVANYSNSGRFKKRFMYPVGYGLPAFIVAVSAIAGHKNYGTHNHCWLSLHRGFIWSFLGPAAAIILINLVFYFLIIWILRSKLSSLNKEVSTLQDTKVMTFKAIVQLFVLGCSWGIGLFIFIEVGKTVRLIVAYLFTIINVLQGVLIFMVHCLLNRQVRMEYKKWFHRLRKEVESESTEVSHSTTHTKMGLSLNLENFCPTGNLHDPSDSILPSTEVAGVYLSTPRSHMGAEDVNSGTHAYWSRTISD
The following text describes a protein:
Function:
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. Probable competitive antagonist of fish muscle acetylcholine receptor. Inhibits postsynaptic nicotinic acetylcholine receptors (nAChRs) from zebrafish (IC(50)=58-100 nM). Blocks mammalian nAChR composed of alpha-1/gamma and alpha-1/delta subunits. Blocks central nervous system nAChR composed of alpha-4-beta-2/CHRNA4-CHRNB2 subunits and peripheral nervous system nAChR composed of alpha-3-beta-4/CHRNA3-CHRNB4 subunits. Low toxin concentrations potentiate currents in muscle nAChR composed of alpha-1-beta-1-gamma-delta (CHRNA1-CHRNB1-CHRNG-CHRND) subunits and central nervous system nAChR composed of alpha-4-beta-2/CHRNA4-CHRNB2 subunits, but not peripheral nervous system nAChR composed of alpha-3-beta-4 subunits. Also exhibits inhibition of D.melanogaster alpha-7/CHRNA7 nAChRs. Has possibly a distinct nAChR binding mode from other alpha-conotoxins, due to a different three residue motif (lacks the Ser-Xaa-Pro motif) (By similarity).
Subcellular Localization:
Secreted.
Domain:
The cysteine framework is I (CC-C-C). Alpha4/7 pattern.
Sequence:
MFTVFLLVVLATTVGSFTLDRASDGRDAAANDKASDLIALTARRDPCCYHPTCNMSNPQICG
The following text describes a protein:
Function:
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Sequence:
MHRPPPPPVASWLLLLPPFVFLCLQNQIAPSADPPPDRSKAAPCLLRGTRSAFPLGEAMSAVITKFAVTSMVMWMAPVAIMYGFIYQIFPGVGQLSPSAQTMASGFLAVISVNLVIGFYIYMAMKETPHQEPQPDPTFLANAKASINQPTSSQVSDDSHGKGKVE
The following text describes a protein:
Function:
Involved in nuclear pre-mRNA splicing (By similarity). Seems to not be involved in polyadenylation.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEMQEANQGGGSEVSPNQTIYINNLNEKVKLDELKKSLNAVFSQFGKILEILAFKTFKHKGQAWVVFDNTESASTAIAKMNNFPFYDKEMRIQYAKTKSDVVAKADGTFVPREKRKRHEEKGGGKKKKDQHHDSTQMGMPMNSAYPGVYGAAPPLSQVPYPGGMKPNMPEAPAPPNNILFVQNLPHETTPMVLQMLFCQYQGFKEVRMIEAKPGIAFVEFADEMQSTVAMQGLQGFKIQQNQMLITYAKK
The following text describes a protein:
Function:
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (By similarity). May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MAGPGTAAAALLPAVLLAVLAPWAGRGGAAPTAPNGTLEAELERRWESLVARSLLAGLPVAAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQVLPDGRIGGVHADTSDSLLELSPVERGVVSIFGVASRFFVAMSSRGRLYGSPFFTDECRFREILLPNNYNAYECDRHPGMFIALSKNGKAKKGNRVSPTMKVTHFLPRL
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Sequence:
WDIAHLLSERLNVDKNTANNIIQMIEVQECTIPFISRYRKEVTHGMDPNTLRMFLDTLKELRDVQKKATTAIRQVQKQEPLDHAVVESLNAAETVEEINVLLAPYKVDKKTLACRARTLGLDNAAKAILNNPRQLINLNEWVKKDCEGRANLKEVKTGVKHIICEAIARDKTTLERIKRYLKPTCLTLEAKMSASKKKAITSQNTSKFECYHHFQHNVSALRSYQVLAINRGEALKELTVKIHISERAENNFIDWCNYKWAEEHKYEDMKTLLKECVTEAYTRLLKPQVLRKTRSELTKTAQMDSVHVFGRNLKKLLLTSPVRGKIILGIDPGYKNGCKCAVVSSNGMEILAVDVFYLHHANPAVSKLLQLLNKFNIQLIGIGNGTACRETEELVSRFIYVSCKKDLKYCIVNESGASIYSVTEEAKQEMPDLDPNLRSAVSIARRLQDPLVELVKIDAKHLGIGMYQHDIPDILMKATLQSVVEDCVTFVGVDLNVAGASLLRHVAGLKKTQVDKILKWREKNGPFINRDQLLEVPGVGKKTFEQCAGFMRIVQKANTPSECQKKSVKTEHVKTEPTDKRKRKITATSKNSKKQKLHHEVNPLDQTWIHPESYKTTEQFLKKINLSSSEVGKDYFISNIKQAVRKKTISQFANELEVGEPTLQLIIDGLSAPCGYRDIRNVTSHFYKTGISCITDLRCGTTMQGKVSNVVDFGIFVDIGVGTDGLVHSSDMKGKWEELRHVLGPNDLISVAVTNVNKPKKRISLRLVKTD
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation.
Subcellular Localization:
Nucleus. Cytoplasm. Nucleus, nucleoplasm. Note=Excluded from the nucleolus. Recruited to the nucleoplasm and chromatin following DNA damage induction.
Domain:
The Phe/Asp-rich domain at the C-terminus is necessary for its incorporation into the CSN complex.
Sequence:
MKPAVDEMFPEGAGPYVDLDEAGGSTGLLMDLAANEKAVHADFFNDFEDLFDDDDIQ
The following text describes a protein:
Function:
Serine/threonine haspin-like protein kinase involved in cell cycle regulation.
Miscellaneous:
MISCELLANEOUS: Present with 2190 molecules/cell in log phase SD medium.
Domain:
The KEN and D (destructive) boxes are required for the cell cycle-controlled ALK1 degradation by the anaphase promoting complex (APC) pathway; The protein kinase domain is predicted to be catalytically inactive. However, weak kinase activity was experimentally demonstrated.
Sequence:
MLLHFDIVIQLLSSHTLKSHQVEPPMDFETSFEEFVEDKRFIALEVSDNDDDCDTDLTADTADELESSAILKMRESDASLNVTTGNNTSRKTTSNSKKRWSLLSNHSAVSSSKSKKRWSVLSSSFTSESHKDRESRNVLQQKRKSLQSYSSLDTVASNSSISASSSLKRSSTGLSLRQLFTKIGINDDISQPGIGIPQGKENLPPTMGKKNSSIASTSSENRLRTPLKPLVNHSKRPTSQPQQQQPLYNASLSSRRSSISSTVSSSSSSKWRFWKRNKNQTPALLQPDHHSLKTFPAVNRRDSMTPVEPRNMVKHKTSFSDFHKTIFSSNTYSESSDTISSMEITLKNKASSSSLSLNVLKKRNSQSSLKHKSSHASLQKFKRNKGKSSMIAPSTATNSSNDDSCSYSSKNSTLSHRISLPVPDQVSRDKIQNKLRYSTSLLSLNSKSSLPMNKNDHDETLLRQILLNCDIKRILNPAKGDVLPLINDVNHLSSIQLTSNVWQIGEVICKKVSLGTIDDITWDRKFLSLQELEKLKIMQQKFDGIPQLLKSFVVKEANGGLYLYLLFKDHGTPISLISLKNWKQILKIFWSCAGIIHGLEKNLKFEHRNLTLDNILIDGNGNITIIDFKCSRLQTPQDDVLYLRLDHPLFFLNGKDKSKINEYQYQFEFEIYQSMRILLNMDASAFEPMTNLYWLYYLSRVLLKFGDRKLGKNDANRDKMARVINHLEMNLAVHKRGGQLFKRLETEDIKNTGDLLKLYK
The following text describes a protein:
Function:
[Isoform 1]: Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (By similarity). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (By similarity). Phosphorylation at Thr-634 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (By similarity). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (By similarity). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (By similarity). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (By similarity). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to sites of DNA double-strand breaks in response to DNA damage.
Domain:
In mouse, the SAM domain is required for deoxynucleoside triphosphate (dNTPase) activity and ability to restrict infection by viruses. It acts by capping allosteric sites.
Sequence:
MDSLLGCGVSAAAREPVPRYLTSQPRVSEVAMQSAPLEQPAKRPRCDGSPRTPPSTPPATANLSADDDFQNTDLRTWEPEDVCSFLENRGFREKKVLDIFRDNKIAGSFLPFLDEDRLEDLGVSSLEERKKMIECIQQLSQSRIDLMKVFNDPIHGHIEFHPLLIRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVRALAEKQPELQISERDILCVQIAGLCHDLGHGPFSHMFDGRFIPRARPEKKWKHEQGSIEMFEHLVNSNELKLVMKNYGLVPEEDITFIKEQIMGPPITPVKDSLWPYKGRPATKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARICEVEYKVKEDKTYIRKVKHICSREKEVGNLYDMFHTRNCLHRRAYQHKISNLIDIMITDAFLKADPYVEITGTAGKKFRISTAIDDMEAFTKLTDNIFLEVLHSTDPQLSEAQSILRNIECRNLYKYLGETQPKREKIRKEEYERLPQEVAKAKPEKAPDVELKAEDFIVDVINVDYGMEDKNPIDRVHFYCKSNSKQAVRINKEQVSQLLPEKFAEQLIRVYCKKKDGKSLDAAGKHFVQWCALRDFTKPQDGDIIAPLITPLKWNNKTSSCLQEVSKVKTCLKF
The following text describes a protein:
Function:
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
Sequence:
MMKWAVVLCALVALSECMHKISLIKGKTAREALEERGLWEEYRKRHPYNPIIKFDPIAAAASNEPLTNDADLAYYGVISIGTPPQSFKVVFDTGSSNLWVPSVYCNSAACGNHNTFNPSQSSTYQSTSQTLTIQYGTGSMTGILGYDTVTVAGIVDTNQIFGLSETEANFMYYMEADGILGLAFPSIAASGATPVFDNMMSEGLVSQDIFSFYLSRNGQTGSILTLGGVDQSYYNGQINWIPLSSESYWQITMDQVTINGNTVACAGGCQAIVDSGTSLVVGPTNDISNINAWVGASQNQYGEAVVSCSNIGSMPKVTFTINGYDFTLPASAYVFQRSSGCSTGFGNGGNDQLWILGDVFMREYYSVFDRANNRVGLAQAV
The following text describes a protein:
Function:
Transcription factor that plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development. May be required for neural tube ciliogenesis during embryogenesis.
Sequence:
MHCGLLEEPDMDSTELIQAPERAPVENVEVSIESWIERCLNESENKRYSSHTSLGNVSNDENEEKENNRASKPHSTPATLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGAAWVSETGKKEVSKQTVAYSPRSKLGTLLPEFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHMLPVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLCQASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDEHRKLIIQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSLKKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSAAEVREEIVLTEAAPPTPSPVPSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRSTHVPSSSVTHRIPVYPHREEHGYTGSYNYGSYGGQHPPPMQSQYPALPHDTAISGPLHYSPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPTANTCYTSPSVHSTRYGNSSDMYTPLTTRRNSEYEHMQHFPGFAYINGEASTGWAK
The following text describes a protein:
Function:
Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Colocalizes with FLNA along actin bundle-like structures.
Sequence:
MVGHLHLQAMGDTREQSRDGLLDSPDSGLPPSPSPSPPFYALSPGTLDTRTTTEAPAAPSLFQTPPALEMRSRLLPVFFGESIEVDPEPAHEIRCNSEITYASERYFRDKIFYAPVPTVTAYSETIVAAPNCTWRSYRSQLTLEPRPRALRFGSTAIIFPKLARSSFRTTLHCSLGQPRHWYSSSLQLRRCGDPTPGPSCPDVL
The following text describes a protein:
Function:
May be involved in the suppression of BCHC1 activity.
Sequence:
MESDSVAGSASSSDAAASHLPSVSVLLDALEQSASTPRIANGLSQRLLRSLQFSNENKLSFKALNGACRVLRLACIQAKESRKSGCVSPLVESSDCGVIVDSPHKKSDSSHTEDCWFECVESCVGIFTEFFSSTNDAKVYVLRSSVCVDCLFELFWEKAVRNNVMKLIIDLMKIRPLCEEDKSAKLQVCSKYLETFTQVKERENDSVDLSVDLLAGMRDLIKSDSRYYQALFREGECFLHIVSLLNGNLDEANGEKLVLNVLQTLTSLLANNDTSKFAFKALAGKGYQTLQSLLLDFFQWKPTQRLLDALLDMLVDGKFDDKGSALIKNEDVIILYLNVLQKSSESLQCYGLNLFQQLLRDSISNRASCVRAGMLHLLLDWFSLENDDSVILKITQLTQTIGGHSISGKDIRKIFALLRSERVGNQQRYRSLLLACLLSMLNEKGPTGFFDMNGVESGIVIRTPVQWPANKGFSFCCWLRVESFPGDGKMGIFSFMSKNGKGCFAALGKDGLSYVSLNLKRQCVNVHTNLVCKKWHFICVSHSIGRAFWGGSLLRCYVNGDLVSSERCSYPKVTDVLTSCLIGTRITLPHIQDNDGLESIRDVFPFFGQIGPVYLFNDSLSSEQVQAIYSLGPSYMYAFLENEMTCPFSDNPFPSGILDGKDGLASKVSFGLNAQASDGRRLFNVSRVSDHLQERLAFEADIMVGTQLCSRRLLQQIIYCVGGISVFFPLITQSDRCESETLNEETSAMPTKERMTAEVIELIASVLDENPANQQQMHLLAGFPILGFLLQSIQPKQLNLETLSSLKHLFNVISSSGFAEQLVEDAISSIFLNPHIWLHAAYNVQRELYMFLIQQLDNDPRLLGSLCRLPRVIDIVWNFYWESERYCKGSKPLMHPTRTIAERPSRDEIHKIRLLLLSLGEMSLRHNISSGDVKALTAFFETCQDVACIEDVLHMVIRAISQTSVLVSFLEQVNLIGGCHIFVDLLQRDYEPIRLLSLQFLGRLLYDVPSERKGPKFFNLAVGRTKSLSQGHKKIGARTQPIFLAMSDRLFQYPQTDNLRATLFDVLLGGASPKQVLQKHNQVDKHRSKPSNSHFFLPQIFVFIFEFLSGCKDGLARMKIISDILDLLDSNPMNVEALMEFGWSAWLTASMKLDVIKDYRSELLNHDDLALNEQHFVRGLFCVVLCHYILSVKGGWQQLEETVNFILLQSEHNDVPYRSFLRDLYEDLIQRLVELSSEDNIFLSHPCRDNVLYLLRLVDEMLVREFGSRLLFPAISTDFSEDLLQLGNREDPTLGLDESFQRFLTEEISRNTECQQSCTTVTELMTNERWWNLYDNLWKIICDINGRGPVKMSPKSLATGPSIGQRARGLVESLNVPAAEMAAVVVSGGIGSALSGKMNKNVDKAMLLRGEKCPRIVFRLVTLYLCMSSLEKATRCVQQVTSLLPSFLAADDEQSKSRLHLFIGCLLYVRSQYGKLDDGARFHVISHLIRETVSCGKSILATSGMNKDDSSDSGGIFKEMGSIQNLIHKDRVLAAVTDETTYMKTLISDRTRQVQALGERNNETLSIECNSKKAFDGELQNVLKTVVTWDENRRVSVQLSHEEQQQNVTEKWIHMLRSLMDERGPWSATPFPNNILNRWKLDRTEDSWRRRPKLRRNYHFDERLCHPPSTSTATENETSNVINESKSGVIHIPEQMKKFLLKGIRRITDEGGSDSCENDSSQAEQSFMDTSADIQFSELVRTSSGLKDVVQDKVDASSLEVGTSEVLTSVPCVLVTPKRKLAGWLAVMKNVLHFSGEFLVEGTGGSAVFKNFSTSKGSDVTKAENKQNLVKWSSPYDSETFLDLESGNKNKKPLKKVKRHRRWKIGKVKSVHWTRYLLQYTALEIFFQESVPPVFLNFASQKNAKEVGMLIVSTRNEFLFPKNVPRDRTAMISFVDRRIAMEMAETARDRWRRREITNFEYLMILNTLAGRSYNDLTQYPVFPWVVADYSSETLDFSKASTFRDLSKPVGALDTRRFEIFEDRYHSFSDPDIPSFYYGSHYSSMGSVLYYLLRLEPFTSLHRSLQGGKFDHADRLFQSVEGSFRNCLSNTSDVKELIPEFFYMPEFLVNSNSYHLGVKQDGEPLGEVCLPPWAKGSPEMFIARNREALESEYVSSHLHDWIDLIFGHKQRGKPAVEAANIFYYLTYEGAVDVENMEDQLQISAIEDQIANFGQTPIQIFRKKHPRRGPPIPIAHPLYFAPASINLSSILPATTHSPSAVLYVGVVDSNIVLVNQGLTLSVKIWLTTQLHSGGNFTFSSAQDPFFGVGSDVLSPRNIGSPLADNVELGSQCFAAMQMPLENFLVSCGNWENSFHVISLTDGRVVQSIRHHKDVVSCVAVTADSTILATGSYDTTVMVWDILRMRTPEKRVRNTHAEVLRKDIVIADAPSHILCGHDDIITCLYVSTDLDIVISGSKDGTCVFHTLREGRYIRSLKHPSGSAVSKLAASHHGRIVLYGDDDLSLHLYSINGKHLASSESNGRINCLELSKCGEFLVSAGDQGQIIVRSMNTLEVVKRYNGAGKIITSLTVTQEECFLAGTKDGALLVYSIENPQHRKPSPIWSIKS
The following text describes a protein:
Function:
Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSDAATRAEETSEGHSSSAIGLMVGAVGVCYGDIGTSPLYTLKEVFIGGYGVQANHDGVLGVLSLIFWSLVWVVSIKYVIFVLRADNQGEGGVMALSALARRAAAPFGRLQTFVVVAGLIGAALFYGDSMITPAISVLSAVEGLEIAFDGLEHWTVPLALIVLIGLFLIQKHGTARIGILFGPVMVLWFGALAALGVYGVIQQPEVLQAMNPVWAVRFFSSHPGIGVAILGATVLALTGAEALYADMGHFGRKPIARAWFLLVLPALVLNYFGQGATILSNAEAARNPFYLLAPGWALLPMVALSTLATVIASQAVISGAFSLTRQAIQLGYVPRMTIQHTSSHEQGQIYIGGVNWALMVGVVLLVLGFESSASLAAAYGVAVTGTMLITTLLMGVVIWRLWKWPLWLGVPFFCVMLAVDSLFFAANLPKVIQGGAFPVIAGIVIFILMSTWKRGRQLLVERLDEGSLPLSVFISSMRVQPPHRVQGTAVFLTARTDAVPHALLHNLLHNQVLHEQVVLLTVVNEDSPRVSPDRRFEVEAYGDGFFRVILHFGFMEEPDIPAALRLCHLNELDFSPMRTTYFLSRETVIPSKRIGMARWREGLFAFLLKNANGNLRYFNLPLNRVIELGTQVEI
The following text describes a protein:
Function:
Part of the ABC transporter complex YclNOPQ involved in uptake of ferric-petrobactin. Petrobactin is a photoreactive 3,4-catecholate siderophore produced by many members of the B.cereus group, including B.anthracis. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKLRYLFILLIILAVTSVFIGVEDLSPLDLFDLSKQEASTLFASRLPRLISIVIAGLSMSICGLIMQQISRNKFVSPTTAGTMDWARLGILISLLLFTSASPLIKMLVAFVFALAGNFLFMKILERIKFNDTIFIPLVGLMLGNIVSSIATFIAYKYDLIQNVSSWLQGDFSLVVKGRYELLYLSIPLVIIAYVYADKFTLAGMGESFSVNLGLKYKRVVNIGLIIVSLITSLVILTVGMLPFLGLIIPNIVSIYRGDNLKSSLPHTVLLGAVFVLFCDILGRIIIFPYEISIGLMVGIIGSGIFLFMLLRRKAYA
The following text describes a protein:
Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MNKIPLFFVFQVFLISGAFSSCENPEIKSTSYTTQDATILTHIAYISEFNVKCGSGSLTNLYSLLGDTIQPVGMTGPNKYQISWTEEVKNARNGDITIKLFDDDGYALLRKAQRAGDDLKTVPHFAVITINHPGTYKGPWISCECLAVAFSLVVCYYAIHFRSKLLA
The following text describes a protein:
Function:
Provides the (R)-glutamate required for cell wall biosynthesis.
Sequence:
MAEKTQRIGIFDSGLGGTTVLKELINSLPNEDYIYYGDNGNFPYGSGKTKNELQKLTERILDFFVKNNCKLVIVACNTASTAAIDYLREKFSLPIIGIIEAGVKIASKNTKNKNIAVISTKFTAESHGYKNKAKMLDSELNVKEIACIEFAQMIETGWDTFDNRKELLNKYLSEIPKNADTLVLGCTHYPLIREDIEKNIKIKVVDPAVEIVERTIQTLTSLNLLNDKKERGRIIFFVTGETYHFKPTAEKFLGKEIEIYRIPK
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MALKAVCVLKGAGETSGTVHFEQEDN