lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (By similarity).
Subcellular Localization:
Melanosome membrane; Single-pass type I membrane protein. Melanosome. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
Sequence:
MLLFTMGLLLAILQPSTGQFPRVCANTQSLLRKECCPPWEGDGSPCGERSNRGTCQRILLSQAPLGPQFPFSGVDDREDWPSVFYNRTCRCRGNFMGFNCGECKFGFSGQNCTERRLRTRRNIFQLTIREKDKFLAYLNLAKNIPSKDYVIATGTYAQMNNGSNPMFRNINVYDLFVWMHYYASRDTLLGGSNVWRDIDFAHEAPGFLPWHRAFLLLWEREIQKITGDENFTIPYWDWRDAEDCVICTDEYMGGQHPTNPNLLSPASFFSSWQ
The following text describes a protein:
Function:
Activates transcription elongation by RNA polymerase II and pyrophosphorolysis as a complex with ell1. Acts as a transcriptional transactivator of ell1 elongation activities.
Subcellular Localization:
Nucleus.
Sequence:
MNSLQKGSYKVIPGSSFSKNSNGLLSIKYNFIPESVDPSRRGVLEKAQEAYRLRLPSTFDDDRPHIFEGSCQRARNVDCVLIFNAKTKTFTLEHIDEIARLNALRNPKVSKTVPSNAITQSDNSQISESKSTSQSAVTTNSTRRKEKELEASKDGKIKPSSSNTRYPAISSKGPITTDTNDEPDMEVMELDDFAKELELGFDQEFNSIDDPSTVSQTASKPISLRGLSSQERDYASSAQAEGISSASEDED
The following text describes a protein:
Function:
Negative regulator of the ER-associated degradation pathway (ERAD) of misfolded proteins. It competes with AMFR/gp78 for binding VCP/p97, and inhibits AMFR/gp78-VCP/p97 complex formation that is required for degradation of ERAD substrates. Involved in the regulation of adrenal cortisol and dehydroepiandrosterone (DHEA) biosynthesis.
Subcellular Localization:
Membrane; Lipid-anchor. Smooth endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Lysosome membrane.
Sequence:
MGLCFPCPAESAPPSPSPEEKRAKLAEAAERRQKEAASRGILDIQSVEAKKKKKEQLEKQMETSGPPAGGLRWTVS
The following text describes a protein:
Function:
In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.
Subcellular Localization:
Endosome, multivesicular body membrane; Peripheral membrane protein. Prevacuolar compartment membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Sequence:
MDTKDSNSSQALAIDGGAQTRPTDDHASLTKRLTQPRSDRSQSPEGRPPPLPPRPETLILLEDGGAAPGTPRPNVSAVHPGLQSRATTAVSLAEISQNDRGKDALAVRSFPGTVRAKASLSHLATPKDGSDAGDSASVTSYVPYSESGDVENIFGSLASSEVGIAQEESTGLMQFPEFQADDVEDDFASELEPVGEIGEGGENEGTVLAYGSTTAETDQLIDLVLEKWKAKRKHYIILSAAGKPIWTRHGDGGLISTYVGIIQTIISSYEDSNDRLNGFTAGDTKFTVVAKGPLYLVAISRILESDTQLKLQLEALYMQILSTLTLPALTHLFSVRPSTDLKRPLQGSETLLSTLADSFTKGSPSTLLSALECLKIRKSHRQTINNTLLKTKVSKLLYGLVVAGGRLVSVVRPKKHSLHPGDLQLLFNMIFEAEAVKAGGGESWIPVCLPGFNSSGYLYIFFELQAMKNALVEKLEENGSINNIKEAIDKGRPSTTDIVPGSVLHHFVYKSRVNVQFIMSAYDPEFSTITRRRRLISTYNNLHASVHAKHTHVKVHHCVTQSSSSFAWITPVFELYCVAGPHANRNALAQSASKVVQWVQKEEERLFIISGAVF
The following text describes a protein:
Function:
Skin-specific kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Involved in skin-specific regulation of sterol regulatory element-binding protein (SREBP) processing and lipid biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MANSQGKYVLSIDSGGSGIRAFLLDRKGNIVERQYEKTPPNIPEAGALEHDPEILWKALLSLLKKIQKNQQIVKEIIALGICNQRGSFLLWEKSTGKPLTPLISWADVRSHKIAEAMNRNLIWTIIRVVSTFVGRLTNHPMMIATSMLRFTTDHATCRLKWILDKNPDLKQRCKKGEVLFGTLDTWFIYKLTGQKQHLTDSSNAVATGMFNPFQLIWNQPILSIFGIPSNLFPEVKDSNGDFGHTLPEYLGGHSIPIRASIGDQMAALFGHCCFERGEVKISQGSGAFVDINIGPKAKLSKRGLFPMIAWRIDGNTTYMLEGYVATAGTLIDWLGQGIGLSDTPKVLNELAAQSEDTEGVVFIPTPTGARFPYFNPRAKASVIGLSLASHRRHVARAVLEGISLSLYEILEGIQRDTKVEIKDIKVDGGVSQSDILLQCLSDFSNVRVNRSPEPDMTATGTAYLAGLAVGFWKNLDELKNLQKGYKSFEPKMNPTKRVQKIQRWKKAVTATLSIE
The following text describes a protein:
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MDALDQVFDPLRDFAKDSIRLVKRCHKPDRKEFSKVAFRTAVGFVVMGFVGFFVKLIFIPINNIIVGST
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCLPNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVISPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQNYTNTPPVIDVPSTGAPSKKSVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQPNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
The following text describes a protein:
Function:
Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MGIPKFFRWISERYPLTSQLITPNSIPTFDNLYLDMNGIIHNCSHPPSTENDPHFRITEEQMILAIFAYIDHLFTKIKPQKVFFMAIDGVAPRAKMNQQRSRRFRAGKDARDQREKAEKNGEKLPDEKAFDSNAITPGTPFMARLSQHLKYYVRKRISEDADWRSIRVILSGHDVPGEGEHKIQEFIRLNKAQPDYNPNTRHCLYGLDADLIMLGLLSHDPHFCLLREEVTFGRKSRQNTELANTNFFLLHLSLMREYLDLEFSSLQTQISFEYDLERIIDDFILMAIFVGNDFLPHLPDLHINEGALERIWGMYKDILPTIDGYINEHGTISLPRLQLLLDKLAEFEVKRFEDDLLDQVHFSGNHTRDTMVIEKARKKNRKVITKYQQKVLNQLRSFIEKQQNQPNPTHRLELINTQDKRDNAFVQELADELHLHTTWDEVDDYGQSLIVCTFNMEGVSQDGSADGKEEDGDWESDEMEDEGKLAVQRVFRNWSKAAVVDTYPEDVEKSMDEKLKEAMDDIKRQYYHDKLEINYNDPAQMQDLVHHYIEGLQWILNYYYKGVSSWGWFYKYHYSPRITDLKGVADMKFEFDYGKPFTPFQQLMGVLPVDSMDHVPLAYRDLMYEETSPIIDFYPRNFELDMNGKKQDWEAVVKIPFIDQNRLLKAMAARDVRLTPEERERNKSGVLSTQFVYDPEIDENYPSSFPGVFPELTRSHCRASPFNLPVLGGDVQLIFGLVEGVQLGVSALAGFPSLDTLPHNGTLDYHGVNVFQSDSKNPSMVITIIGKDELPKTSEIARNVLGQRTFHSWPYLQEGIVAAVSDDMFKYTLQQVGKSLRVVHMPHQDAVKWRRQADHVERHYSRRYGVIIGGVEVLLHIRPLKGLKHLDNGALVKDYETPEKEIVQAYQVAVSQVTFEDERFLERAPPDLKVDFPVGEKVLFLGDMHYGLAAQVSAVNEEAQTLSVILAYFEEETEETLRFMKAVAHRPAGKWWPSPILSRRLGISALALSRITSTLLVQLGDGSKTNIGLSLKFESRGLKVLGYSKRNDRGWEFSEKTAQVLEAYKKAFPEVFKHLENRGGDLVKSKELCPTAEDPDTVIKGMKKWLKDEGLNDLESVSLFADQLEAETCQIVEKLADDILSKKTFQSIKKKRLDNVPRQTLLKPAQAIYRLQGQVFEPGHRVVMVQDPAAGGVPTGMRGVVVGLGMRTVDVIWDNGFMGGSTLQGKCSPYRGSTVPFSSCLNLTRPQFTVSERAGPKPVPQNVFRPQLGPRPAVPMQHYQPSVPGRQQTATTTHHILQKPKTVHSTQSTTVVGSNGHLKYSGVAKGVRPQPVQQQPVSHRDQLSNLLGGLRLGPGPVVNDNRDSSHVTHVQAQGNLPVVHSHASVHQAIPTNPPIRGKAQNMNNKSGIGAVRGRGAANGAPFAHRGTHNGVPASARGGAPNGGPRGRGGFRGGSRGFTRGRGVGSGGSAVVEE
The following text describes a protein:
Function:
Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, stress fiber. Cell junction, focal adhesion. Cell projection, ruffle membrane. Synapse. Note=Colocalizes with F-actin and COMMD1 in the nucleus. Colocalizes with MAP1A along actin stress fibers and membrane ruffles.
Sequence:
MYSEIQRGRADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRRIATLTSEEREL
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPPTIRVIGSLNADMVSVTPRFPDAGETITSSSYFTSAGGKGANQAVACGRLSRSQPQSSSFSTSINTGDVNVEMVGAVGGLDGHFSALLKPTLEKSGVDTSRVKVVEDAYTGVAVIIVDSSAGGENRILFSPGANYSGMQADPSVVGMALAEPAPDVIVMQGEIPTETTVAILREIARWKEQQRADGKRGIDAGPDVMFNPAPAPPGGLPEDVYKGVDHLIMNETEAELMTPDEDVLLRVPGIESAQDGKEKVARYFHSLGVRYVIVTLGAKGVWYSAADPDTLGDRVVNEVPAAKVSRVLDTTAAGDTFVGAYAVQAARWREGRRREGKAGKDLDAEEKKHRYKNVMDEAMGVATRASARGVERQGAMDSIPWENEI
The following text describes a protein:
Function:
Involved in meiotic recombination in association with MSH4. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. Promotes homologous recombination through facilitating chiasma formation during prophase I. Involved in the control of class I crossovers formation.
Subcellular Localization:
Nucleus. Chromosome. Note=In pollen mother cells during meiosis, localizes to unsynapsed axes during leptotene and zygotene, but is not present on synapsed regions of zygotene nuclei.
Sequence:
MEEMEDTETEPQVYMACIQHGRRVGVSYYDCSVRQLHVLEFWEEDCSDFTLINMVKYQAKPSIIYASTKSEESFVAALQQNDGTDETTMVKLVKSSTFSYEQAWHRLVYLRVTGMDDGLNIKERICYLSSMMDVGSEVQVRVSGGLLAILESERIVETLEQNESGSASIAIDSVMEVPLNKFLKLDAAAHEALQIFQTDKHPSHMGIGRAKEGFSVFGMMNKCATPMGRRLLRSWFMRPILDLEVLDRRLNAISFFISSVELMASLRETLKSVKDISHLLKKFNSPTSLCTSNDWTAFLKSISALLHVNKIFEVGVSESLREHMRRFNLDIIEKAGLCISTELDYVYELVIGVIDVTRSKERGYQTLVKEGFCAELDELRQIYEELPEFLQEVSAMELEHFPHLHKEKLPPCIVYIQQIGYLMCIFGEKLDETALNRLTEFEFAFSDMDGETQRFFYHTSKTRELDNLLGDIYHKILDMERAIIRDLLSHTLLFSAHLLKAVNFVAELDCILSLACVAHQNNYVRPVLTVESLLDIRNGRHVLQEMAVDTFIPNDTEINDNGRIHIITGPNYSGKSIYVKQVALIVFLSHIGSFVPADAATVGLTDRIFCAMGSKFMTAEQSTFMIDLHQVGMMLRQATSRSLCLLDEFGKGTLTEDGIGLLGGTISHFATCAEPPRVVVCTHLTELLNESCLPVSEKIKFYTMSVLRPDTESANMEEIVFLYRLIPGQTLLSYGLHCALLAGVPEEVVKRAAIVLDAFESNNNVDKLSLDKISSQDQAFKDAVDKFAELDISKGDIHAFFQDIFTS
The following text describes a protein:
Function:
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
Miscellaneous:
MISCELLANEOUS: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALGKLMFEELRNAGRGGGVGGFLPAMKQTGNMAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGFDINCGVRLLRTNLDESGVQPVKEQLAQTMFDHIPVGVGSKGVIPMSAKDLEEALEMGVNWSLREGYAWAEDKEHCEEYGRMLQADPNKVSARAKKRGLPQLGTLGAGNHYAEIQVVDEIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKIIVNNRQLACARIASPEGQDYLKGMAAAGNYAWVNRSSMTFLTRQALAKVFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVDYQLTGQLMLTGGTTGTCSYVLTGTKQGMTETFGTTCHGAGCALSRAKSHHNLDFQDVLDKLADMGIAVRVASPKLVMEEAPESYKNVTDVMNTCHDAGISKKAIKLRPTAVIKG
The following text describes a protein:
Function:
Involved in the degradation of galactose via the DeLey-Doudoroff pathway. Catalyzes the reversible, stereospecific retro-aldol cleavage of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) to pyruvate and D-glyceraldehyde-3-phosphate. In the synthetic direction, it catalyzes the addition of pyruvate to electrophilic aldehydes with re-facial selectivity. It can use a limited number of aldehyde substrates, including D-glyceraldehyde-3-phosphate (natural substrate), D-glyceraldehyde, glycolaldehyde, 2-pyridinecarboxaldehyde, D-ribose, D-erythrose and D-threose. It efficiently catalyzes aldol addition only using pyruvate as the nucleophilic component and accepts both stereochemical configurations at C2 of the electrophile.
Sequence:
MQWQTKLPLIAILRGITPDEALAHVGAVIDAGFDAVEIPLNSPQWEQSIPAIVDAYGDKALIGAGTVLKPEQVDALARMGCQLIVTPNIHSEVIRRAVGYGMTVCPGCATATEAFTALEAGAQALKIFPSSAFGPQYIKALKAVLPSDIAVFAVGGVTPENLAQWIDAGCAGAGLGSDLYRAGQSVERTAQQAAAFVKAYREAVQ
The following text describes a protein:
Function:
Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MALYFDHRIEAPDSVGSPSHISWHPVHPFLVVASISTTSGGSVDIYLEQGEPVPDTHIERSVRVTSLCWHPTRLILAVGWETGEVVVFNKQDKEQHAVPPTHTADITILTWSTSGNCLVSGDKLGVLLLWRLDQRGRVQGTPLLRHEYGKHLTHCIFRLPPPGEDLVQLAKAAVSGDEKALDMFNWRKSGFGNFLKMGSQEGLSFFVSLMDGTVHYVDEKGETTRVASTESSIQTLFYIEKREALVVVTENLLLSLYLVTPEGEAEEVMKVKLSGKTGHRADIALIEGSLLVTAVGEAVLRFWDLERGENYVLSPEEKFGFEKGENINCVSYCKVKGLLAAGTDKGRVAMWRKVPSPPNSRGVEGKDRWTLQTPTELEGNITQIKWGSRRNLLAVNNISSVVVLSEQAMSAHLHQQVAVVQISPSLLSVAFLSTGVTHSLRTDMHVSGVFATKDAVAVWNGKQVVIFEPSGAALRNAGTFLCESPVLAMHEENVYTVEPNRVQVRTWQGTVKQLLLFSETEGNPCFFDICGNFLVVGTDLAHFKSFDLSRREAKVHCNCKSLAELVPGAGGMASLRCNANGSKISILLSKADNSPDSKICFYDVEMDTVTILDFKTGQIDRRETLSFNGQETKKSHAFADERLTNLIPVSHFWDQSEPRLFVCEAVREVPGAQLLPTDKKPHAEDGAGPLADVLILSFFISEEHGFLLQESFPQPPTFQTLLGIEVPHYYFTRKPGEADREDQVDSGYHRIPQLVGRRPLRDFVGLEDCDKPTRDAVLNFSFFVTVGDMDEAFRSIKLIKSEAVWENMARMCVKTQRLDVAKVCLGHMGHARGARALREAEQEPELEARVAVLAIQLGMLEDAEQLYKNCKRYDLLNKLYQASDQWQKAVEVAELHDRIHLRTTYYNYARHLEASADCSRALTYYEKSDTHCFEVPRMLSEDLHSLELYINKMKDKTLWRWWAQYLESQAEMEAALRYYELAQDHFSLVRIYCFQGNIQKAAEIANETGNWAASYHLARQYESQEEVRQAVHFYRQAQAFNNAIRLCKENGLDDQLMNLALLSSPEDMIEAARYYEEKGEQMDRAVMLYHKAGHFSKALELAFATQQFVALQLIAEDLDEKSDPALLSRCSDFFLEHSQYEKAVELLLAAKKYHEALQLCLEQNMTITEEMAEKMTVAKDSKALSEEARRELLEQIAHCCMRQGNYHLATKKYTQAGNKLKAMRALLKSGDTEKIIFFAGVSRQKEIYIMAANYLQSLDWRREPEIMKNIIGFYTKGRALDLLAGFYDACAQVEIDEYQNYDKAHGALTEAYKCLSKAKAKSPLDQEARLARLQSKMALVERFVQARRTYTEDPKESVRQCELLLEEPDLDSTIRVGDVYGFLVEHYLQMEEFQMAYKYLEEMRRRLPSANMSYYVSQRTVDAVHQGLGIPLLRVAPERTRHNSMEDHREMGEEVAEEVENDP
The following text describes a protein:
Function:
Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space.
Sequence:
MKYLFLTRAFWTLKGLRADSRAPATAASPSAPALPVHSPQPPSAEPQRPLPSPTTAGRRMEMLCAGRVPALLLCLGFHLLQAVLSTTVIPSCIPGESSDNCTALVQTEDNPRVAQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVALTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV
The following text describes a protein:
Function:
Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).
Subcellular Localization:
Nucleus.
Sequence:
MGPCSHPRLGLPGSESSSQPPKRRKKRYLRHDKPPYTYLAMIALVIQAAPSRRLKLAQIIRQVQAAFPFFKDDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQSRGARGAFAKDLGPYVLHGWPYRPPSPQPPPSPQPPPSEGFSIKSLLGDPGEGAARGSPGEEGVRTPPLPCEQPPWPPCLLTGPRRADGEASQGGTSRPPPLSPEHRAWPLHLLQASPDPGGLPGGSHRPSLWGQLPTSYLPIYTPNVVMPLAPLPPASCPQCPPSTSSAYWGVASETHGPPGLLWDLDALFQGVPPNKSIYDVWVSHSRDPAASTPGWLLSWYSL
The following text describes a protein:
Function:
Probable glucose transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTAQIPYQHSSGYISHFHNNELDAGRGRDYNVTIKYLDDKEENIEGQAAKISHNASLHIPVLLCLVISLGGFIFGWDIGTIGGMTNMVSFQEKFGTTNIIHDDETIFVSTKKLTDLQIGLIISIFNISCGVGALTLSKIGDWIGRKGGIWFALVVYCIGITIQILSYGRWYFLTLGRAVTGIGVGVTTVLVPMFLSENSPLKIRGSMVSTYQLIVTFGILMGNILNFICERCYKDPTQNIAWQLPLFLGYIWAIIIGMSLVYVPESPQYLAKIKNDVPSAKYSFARMNGIPATDSMVIEFIDDLLENNYNNEETNNESKKQSLVKRNTFEFIMGKPKLWLRLIIGMMIMAFQQLSGINYFFYYGTSVFKGVGIKDPYITSIILSSVNFLSTILGIYYVEKWGHKTCLLYGSTNLLFYMMTYATVGTFGRETDFSNIVLIIVTCCFIFWFAITLGPVTFVLVSELFPLRTRAISMAICTFINWMFNFLISLLTPMIVSKIDFKLGYIFAACLLALIIFSWILVPETRKKNEQEINKIFEPE
The following text describes a protein:
Function:
Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Note=In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases; [Leucyl-cystinyl aminopeptidase, pregnancy serum form]: Secreted. Note=During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.
Sequence:
MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVVAVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL
The following text describes a protein:
Function:
Could be a regulator of the dopamine receptor signaling pathway.
Sequence:
MKTLFEEIKASIKNNYNQDRSFWRPVLPWGGVFTIKAGRKAVSCTPLYVEIRLKNTCTIDGFLMLLYVILNENESFPRELSLHFGREFVDCFLYLMDTYSFTTVKLLWIWDKMEKQQYKSEVHKASLVIDLFGNEHDNFTKNLENLMSTIQGSYCSNWHCPTRVQEDQQRTISINPPQEIPHGNLIRLAVDELFCSKIELCEERGCGGLREFSQRVFCHGAPPFVVLNMQHWKPEDLAYVPYYLDLSDHKYLLEGATLFNKEEHHYSAAFQIDGHWMHYDGLRNVNLILLNKPPEFLLLSSLVYIRATEK
The following text describes a protein:
Function:
Required for correct meiotic chromosome segregation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MEVPSYFDPDYDPSSLRVVDLRNILTEYQIYYPSTAKKAQLITLFSKLRRAKNGLISMTELQQKNVPPSSRSPRRRVAGVTNNVTARISSKRKINMVDEANDTEISKTSQFEDNVMGMLQDENVQVLNTNTITISEESEFHASKIAKIDSRNEEITHIPFETQTELNAAVVNLDNSMESSFSIVQNLTNKDSSVDTATYDFSAEVGNIVTPASKFLDYDQSYLVNASVSGDPTPVKVLNTTSPKSENPLNQSSFLSFLGENLKPKFTSRSSSVYASPIKSSLNSLECNPSNLLSVRKNFQQSSDSYLKSNKSFDQLNNLVGLSTGNSENFTPENNSFSWTHPKKNSSSPLPQSQSSSIFVEHLNQLYEANASIHRPVNPAFSTNFGLEASNTSTPEKKKFDSQKPDDDSVNEISSDLGLSTTGIDRVEENISLTKDRQPKRPYFSLGSFISLIFSFTKVVNSLWLVLLVVPLLGFVGFWHQEVQRVGFCGVPAEPYPSSLYYLQPGVLRSSIESAYSFAHSLGIEASCQPCPENAECGFNRQLFCKEGLKASFPLLADFGLKPYPRCIPNTVKVNKVEEMVQAFMSIIGKWYYKAPKEFATFESAKNLNGKSFVDNFKDRYYMYKQDIDNVVGLKDFKVYLKTTLNRLYNSKLTRKVLYYLFSPLFTLELWKLRVRGALSKFPTNCLRSVYSHTVSLMKYLTSAVISCWRIYLLIGILAAITGTVVWRIRVYAKKHVVKHGVSVCVSHCIAKLQKTKLKSLTDFSVNPRVEVVQLRSDCFVSGVADDKGLFELVHLPLSIQLEIWEKVVSVLEGMVSVKVWDSERLAKNRAWEWIGVFSDDIAL
The following text describes a protein:
Function:
Actin filament (F-actin)-binding protein which may play a role in cell-cell adhesion.
Subcellular Localization:
Cytoplasm, cell cortex. Cell projection, filopodium. Cytoplasm, cytoskeleton. Note=Localizes to points of cell-cell contact in the pinacoderm. Localizes to the base of the microvillar collar in choanocytes. Detected in filopodial extensions in migratory cells of the mesohyl. Colocalizes with F-actin.
Sequence:
MPVKFHTKTLESVIDPVAQQVGQLVLFHEQAESGLLKEDLTPLVQGVGIAVTNLVQVAASMVETSNDEDFKAELPPSMQEVQQAAVFLSDAARLLKADQGSPEGKRKLLDGARGVINGMSDLLMCADRSEVRKMVKVCRSVQEYLDVAKVIDVEADLATFLQNLTPGMTSMMKVVEQRHPELTNLAHAQMLKSELGTVREQIPILISSIRVCCLVIVKDGSSGMKDAAFGRDYVIQKLFIAIEEIIRVLQLTTTFEEEEVGGAGAASAASLAHMFHQAQDALASGDISRSTLDAVRKCISEGRRVAALAATDETRAKLLAAADELDQILKELEELQAKGLGDSRQARALAHAAAVKLQELEQEIRKALAERVATDFVNVGGPIKALEDAALASPSDPNRQANFAQKAKEFEAHTARLADTAELVASSGGCSDAVAAELRKEAAKLRDISTAVVPAARVVLENPGNQAAKDYLRTVKEKWLEAAESMGRSVDGVIDSLEFMKVSEARIQADVKEAKRIALAEEDSMKLIAKASSVARQANRVIQVAKVEADNSENPEFVAKLSSASESLAKSISPMVIEAKAVVTSPQNKDIQRKFCSSADKVVEGVAAVRSVIEDNWVPPRPPLPELEEEEEPPELPPPPEDPASLLPAEMQEAEEMLRAPLPPKDQNPIHHAAASVFREADQWDEKGNDLISLVKQMARKMAMMSKYTRGESGEVRSKADLIRMAKEIALNAQELLKLARQIANACMDKRAKTNLLQLLDRIPTISTQLKILATVKATSMGGGDARADADATDMLVGNAENLMRTVKDVIRASEAACIRLRPDSPIASILWRKKGGQGRRISVSY
The following text describes a protein:
Function:
This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MAQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLLKSD