lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane. Membrane; Single-pass membrane protein. Prevacuolar compartment membrane.
Sequence:
MSISPRQYASLSLLHPPSPKTTWTMLLLFIIASILSVAPLSVLAGDPEVTVSRIDNLPNRLFYFDDTPVVMYHDPVKLTVHRSADEGKTWEQVSGPQEGDAARLIEHPHNNEMAFIIGRYSVHWVTYNRGASWQSFETPRDASLTGKTLSFHAEKDEWILFQGVACENTGSGKWGEGKTCWDETYYTTDAFRSEPQLLLSQTSQCLFARSSESFKSAPESLIFCVAFDQSQKPGSGGMHSYKESRLFSSEDWFATKKFVDLGIGKRARGVVGLGVVSKFMVVALRAEGTATKRASGGDPMSLYVTTDGLEWRQTQFPHSALPDLKENAYTVVESTTHSIAVDILTSPSANIGTLFVSSSEGTYFVEALADTNRNEYGIVDFEQLVGLEGIGIANVVSNREQVVGWGEAKKIKSKITYDDGSSWRPLKAPAKMMNGDDWACDTSDLESCSLHVHSVTVPHNIGRVFSSTAPGYVMAVGSVGNSLLPYEDCDTFLSTDAGLTWRMVREGAHKYEFGDQGSILVTVDDEQATDHVHYSYDGGNSWIPLDLGITIRGIVLTTIPDSTSQKFLLLGTLPRKDSNGGRHAMVFLDFAPLQTRQCTDSDFERWYARSADGKECLMGHRQWYQRRKLDAQCYVGHKFEDPVGHEENCACTDDDYECDYNFVKQDGECVAVGPETVPAGTCHKEGDKYLGSPGYRKIPGNTCEVRSGQAKDSPIMKDCSSARPESGKPSHVVHEFTSDIASHSYFPLSQTILLQLADSTVWQSSNEGFSWKQLYPDETFLGVVIHEHSPERAYLLTPTRKIYYTTDTGRSWNTIDAPADPNNLGIAILDFHPTKADWLIFVGAIDCKDPLSSSCRAVAYYSTNHGRGWNKIDEYVRTCAWARDKRLKIDEREIICESYKNKKGSQVSGEYNPMELIAGASYYSKKIKLFDAVVGFATFSEYLLVAQLHEAQGTLSLQVSLDGYNFAEGQFPPNMKIDNHAYTILESSTGSVFLHMTMNSAVNNEWGSIFKSNSNGTYYGLSVEYVNRNSAGYVDFEKMLGLDGIAVINIVANPSEADISRRKKLQTRITHNDGGSWKPLNPPAKDSLGQEYDCQWTSCSLQIHGYTERRDPKATYSSPSAIGLMLAVGNVGEELAPYTDSDTFLTRDGGYTWEEVHKDAHMWEFGDSGSIIVLVNDEEPTDHVLYSTDEGLTWSEYPFGQTLRVRTIQTVPDDTSRRFFLIGTPPSSPDKTTLVHLDFSAITQTKCVLSIEDPNHDDFELWSPSESREDKCLFGRQTMYHRRIREKNCYIGERVEQPKTIVRNCTCTPSDFECEFNYRRDSSGKCALVDGATALSWNTEEEQCDGYTEFWYERTEYRKIPYSSCEGGERPDRGKRHECPGLIIGGARRGVLVWGSIVILPFAFAGLAGYWWYKKGSRAGSIRLGDHRAFGGDSSSGVLAVVASVPMFLIAIGQEGWAWVARRVPFIEDLFTRRSSSYRSVPIDEDAEILGNYEDE
The following text describes a protein:
Function:
Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Mainly localizes in the female pronucleus, localization to the male pronucleus in much weaker (By similarity). Expressed during blastocyst, morula and 4-cell embryo stages.
Domain:
Mediates binding to H3K9me2 via N-terminal region, while ability to exclude TET3 from the maternal pronucleus requires the C-terminal part.
Sequence:
MDSSEDNPTWTLESLKTSIDDASQAMQVATQLSEMLATNLSNLTLNPSIKLPYLPEYPSQLTGQLPSEKTPHRRRGVRTVLSERRYRMQKLIESLRLRYAKGIPRSDSQRQLQQQEDTEIRSRVRRFQCTCSYCQFKRNPSDDNYENYYNTTYSNYAMESNES
The following text describes a protein:
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.
Sequence:
MAVSMETFAQWKNTTLGKLDQSRKGSVDERARHVVCLLNSQERFFTTSSCSGRIVLMDGPPEGGVVQKKDCRWLFISHDPCRSEDLVSALSRSSGEAVLKFEAFVLHVQCHRLEDAQLLHSVAVNSGFRNSGLTVSRSGKIIMAVRSTHGLEVPLSHGGKLLVGEEYVHFLTQKANQKMEENFRRIHRSVRCPLPGRLKNWTASETLFRFFQILQAALTAETPDLQGAEDPAVTPGEQENQAAVYRRRRKRHQSQTHAELDEEDSCSLDDCLDLFS
The following text describes a protein:
Function:
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDHENTGENTSEYQYKQPPQKSIDELLNADKEDESLKVYKAKLLGQGTVIVDEKNPLRVIVRSVELLINGKTAQSFDLSDPAKLVNSDLSVSIKEGSNYRLSFAFHVQREITSGLHYKHKVKRSGITVENEKYMMGSYAPKLEIQEYKSPNEEAPSGMMHRGKYKVYSKITDDDNNVYLDWQWTLHITKE
The following text describes a protein:
Function:
Thiol protease that cleaves dipeptides from the N-terminus of protein substrates. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine or lysine cannot occupy the P2 position of the substrate. Involved in host hemoglobin degradation by generating dipeptides from hemoglobin-derived oligopeptides.
Subcellular Localization:
Vacuole lumen. Parasitophorous vacuole lumen. Note=In schizonts, the immature form localizes to the parasitophorous vacuole. In trophozoites, the mature form localizes to the digestive (or food) vacuole, an acidic vacuole where host hemoglobin is digested.
Sequence:
MAKRIFSVSFLLVLLNVLHICIKFSVADLPTHVETKNLLGKWKILRTKTSPNLTTCGSSQPNKNTYNVGITDYKKYLLENNYEFVSELNVILSDDYVLYGDIYNTQDNEHRSKWKVLAVYDENKRVIGTWTTICDEGFEIKIGNETYAALMHYEPNGKCGPVSDEDSLDSNGDTDCYTTSFSKIRYGWLDVENEKNEHLHGCFYAERIFDNVNEIKHLDSFTIDKDSQNVLQTFTYDTKLNNILNSNNMLYKFGNLQKPTFTKRNNTNVQFNSELNWHRMKHHGKKKPLKKSMLDASRQTYACPCNANEVVDNVINKGDSDNPVSPTLIQLNNNLKNTTQTGNKDTNEMDLENYEDTLNSPKRELEINELPKNFTWGDPWNKNTREYEVTNQLLCGSCYIASQLYAFKRRIEVALTKKLDRKYLNNFDDQLSIQTVLSCSFYDQGCNGGFPYLVSKLAKLQGIPLNVYFPYSATEETCPYNISKHPNDMNGSAKLREINAIFNSNNNMSTYNNINNDHHQLGVYANTASSQEQHGISEENRWYAKDFNYVGGCYGCNQCNGEKIMMNEIYRNGPIVSSFEASPDFYDYADGVYFVEDFPHARRCTIEPKNDGVYNITGWDRVNHAIVLLGWGEEEINGKLYKYWIGRNSWGNGWGKEGYFKILRGQNFSGIESQSLFIEPDFSRGAGKILLEKMQKELGN
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MTESSQQRRSTFNRYIAAAVAILLPILPQQAIQQLPPAVLADVNTVCREATYFTVASNQYVQKLQQLSSDLTSSQIQTKVWQLAAAKAAAVDKKAFYTSLIAYDNKRRREAAITATAAIQAVTRALAAVARQAGYLNGREHAADLLAGAALAGDPTHSGTRCTHAITQTPTTFSTCTDGSLEAAGFTNTDLDIFRTTHVKISKHSDLKTLTSTSNVIATTTGTTFTGASAGKCQDSSESGITDVQLSLKLTKEASLSTAASKLKNHGTARDSCRQKPEQQQVEANEDKLERLICEAQQAVAKAKLDITGLDVAALQADEVMLEATNNLAMGNERVGDPTKREGKEAVAKKIAALAGDPTNFYATFVSELNKQKVTFKKAGKTTEKSLEDIAKSDDFGIAVSYFEGQSMLAIADAATKTCKPQLTETEATCAARGAGDDCKSPCKLVEEEGGKKKCTLDAKAAKKQAQNQETEDKDDKTTSTTGSNSFLITKAPLLLAYLIL
The following text describes a protein:
Function:
May play a role in the establishment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not show this retardation, suggesting growth may be regulated through an ATP-dependent function.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MSSGNSSLGIIVGIDDSPAAQVAVRWAARDAELRKIPLTLVHAVSPEVATWLEVPLPPGVLRWQQDHGRHLIDDALKVVEQASLRAGPPTVHSEIVPAAAVPTLVDMSKDAVLMVVGCLGSGRWPGRLLGSVSSGLLRHAHCPVVIIHDEDSVMPHPQQAPVLVGVDGSSASELATAIAFDEASRRNVDLVALHAWSDVDVSEWPGIDWPATQSMAEQVLAERLAGWQERYPNVAITRVVVRDQPARQLVQRSEEAQLVVVGSRGRGGYAGMLVGSVGETVAQLARTPVIVARESLT
The following text describes a protein:
Function:
The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MNFSEVFKLSSLLCKFSPDGKYLASCVQYRLVVRDVNTLQILQLYTCLDQIQHIEWSADSLFILCAMYKRGLVQVWSLEQPEWHCKIDEGSAGLVASCWSPDGRHILNTTEFHLRITVWSLCTKSVSYIKYPKACLQGITFTRDGRYMALAERRDCKDYVSIFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLAVWDTCLEYKILLYSLDGRLLSTYSAYEWSLGIKSVAWSPSSQFLAVGSYDGKVRILHHVTWKMITEFGHPATINDPKTVVYKEAEKSPQLGLGCLSFPPPRAGAGPLPSSESKYEIASVPVSLQTLKPVTDRANPKIGIGMLAFSPDSYFLATRNDNIPNAVWVWDIQKLRLFAVLEQLSPVRTFQWDPQQPRLAICTGGSRLYLWSPAGCMSVQVPGEGDFAVLSLCWHLSGDSMALLSKDHFCLCFLETEAVVGTACRQLGGHT
The following text describes a protein:
Function:
Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly. Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, filopodium.
Sequence:
MGAGGRRMPVRSARLLLLPLLPCLLLLAPGTRGAPGCPVPIRGCKCSGERPKGLSGGAHNPARRRVVCGGGDLPEPPDPGLLPNGTITLLLSNNKITGLRNGSFLGLSLLEKLDLRSNVISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIYSSLQPGVFDELPDLKIVDFGTEFLTCDCRLRWLLPWARNHSLQLSERTLCAYPSALHAHALSSLQESQLRCEGALELHTHYLIPSLRQVVFQGDRLPFQCSASYLGNDTQIHWYHNGAPMESDEQAGIVLAENLIHDCTFITSELTLSHIGVWASGEWECSVSTVQGNTSKKVEIVVLETSASYCPAERVTNNRGDFRWPRTLAGITAYQSCLQYPFTSVPLSGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSGIVGALERIGGAALSPHAQHISVNSRNVALEAYLIKPHSYVGLTCTAFQRREVGVSGVQPSSPGQDVPLEPEALADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSTLPAALAPPVPPDCTLQLLVFRNGRLFRSHGNTSRPGTAEPSKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGTDPLAAWWNQDGPGGWSSEGCKLRFSQPNVSSLYCQHLGNVAVLMELSAFPREAGGSGAGLHPVVYPCTALLLLCLFSTIITYILNHSSIHVSRKGWHMLLNLCFHMAMTSAVFVGGVTLTNYQMVCQAVGITLHYSSLSSLLWMGVKARVLHKELSWRAPPPEEGEAAPPGPRPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILPITWIYFLCAGLHLRGHVAQNPKQGNSRLSLEPGEDPRGSTRLRSSGVLLSDSGSLLATVSAGVGTPAPPEESDGVYSPGVQLGALMTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPSASHAPPRALPTAAEDGSPVLGEGPASLKSSPSGSSGRAPPPPCKLTNLQVAQSQVCEASMVARGDGEPEPTGSRSSLAPRHHNNLHHGRRVHKSRAKGHRAGETGGKSRLKALRAGTSPGAPELLSSESGSLHNSPSDSYPGSSRNSPGDGLPLEGEPMLTPSEGSDTSAAQIPETGRPGQRRSASRDNLKGSGSALERESKRRSYPLNTTSLNGAPKGGKYEDASVTGAEAIAGGCMKTGLWKSETTV
The following text describes a protein:
Function:
Potential transcriptional regulator that is required to activate expression of a number of early meiotic genes including HOP1.
Sequence:
MSIEEEDTNKITCTQDFLHQYFVTERVSIQFGLNNKTVKRINKDEFDKAVNCIMSWTNYPKPGLKRTASTYLLSNSFKKSATVSLPFILGDPVCMPKRVESNNNDTCLLYSDTLYDDPLIQRNDQAGDEIEDEFSFTLLRSEVNEIRPISSSSTAQILQSDYSALMYERQASNGSIFQFSSP
The following text describes a protein:
Function:
Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation.
Subcellular Localization:
Mitochondrion.
Sequence:
MMLKSITESFATTIHGLKAGHLTDRVIQRSKRMILDTLGAGFLGTSTEVFHKASQYSKIYSSNITSTVWGRPDIRLPPTYAAFVNGVAIHSMDFDDTWHPATHPSGAVLPVLTALAEALPRSPKFSGLDLLLAFNVGIEVQGRLLHFAKEAKDIPKRFHPPSVVGTLGSAAAASKFLGLSSTKCQEALAIAVSHAGAPMANAATQTKPLHIGNAAKHGIEAAFLAMLGLQGNKQVLDLEAGFGAFYANYSPKVLPNLDSYSWLLDQQDVAFKRFPAHLSTHWVADAAASVRKNLVAETALLPIDYIKRIVLRIPNVQYVNRPFPDSEHEARHSFQYVACAMLLDGSIAVPAFHECQINRPQVRELLSKVELEYPPDNLPSFNTLYCEISVTLKDGATFTHRSDTFYGHWREPLSQEDLEEKFRANASKMLSCDIVESLIKIVENLEDLEDCSVLTTLLKGPSPPEVASNSSAYNNSITNLS
The following text describes a protein:
Function:
Acts as a ligand for sevenless tyrosine-kinase receptor during eye development.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKVMDALQSGRRKPLPVALLCILVTVFCVLECHGADLTSPTKKSAPLRITKPQPTSQQAKPISITTRAPTTVASTTDDEVSSSVDGQLAPLISSTTEGPSSGTTASLVPEICLNGLQLTVNSADEGTVIRKQEEFVKILEGDVVLSVLTKDPDSALFVINRVNQANLIMADFEIGIRAISIDNASLAENLLIQEVQFLQQCTTYSMGIFVDWELYKQLESVIKDLEYNIWPIPGTRAHLFPKVAHLLHQMPWGEKIASVEIATETLEMYNEFMEAARQEHMCLMHFKSDDNVYIMFGNKLASHFKENGTLFSVPTDRTDDEFLADLPNRAFVLMENEIDLSTAVELDATPTALDEILIGKSVLPSRVLSFAGSIIDLMNWLRGSLSKHCKRGEEHDLYVLESCFNFLNFIEDWRTSEYRQAHDTAEILSLLLMRKLGTAMNFQMYQKKVLTLDKITGESRTELREIASQNFVTNVTTYYHYNRDNHTSLELKTKFGQVFNCQYSAGDNRRYPFLFDGESVMFWRIKMDTWVATGLTAAILGLIATLAILVFIVVRISLGDVFEGNPTTSILLLLSLILVFCSFVPYSIEYVGEQRNSHVTFEDAQTLNTLCAVRVFIMTLVYCFVFSLLLCRAVMLASIGSEGGFLSHVNGYIQAVICAFSVVAQVGMSVQLLVVMHVASETVSCENIYYGRWLWGLLAYDFALLCCVGALIPSIYRSQRNYREGILIVIGSVLIMVIWVAWIALSLFGDEWRDAAIPLGLQASGWAVLVGILIPRTFLIVRGIERSDIAQALPSLTSLAFAQNNQYSSEQSVYECVNPAMRHCSQDEVNHQSPSEIPTLPLRGGGPRRQQFFANLRQANANINPQRPPPRPQQSPSRSSVSSLPPSPDHNKITRF
The following text describes a protein:
Function:
Acts on leucine, isoleucine and valine.
Sequence:
MKEVGKIWMNGKLVPFKDAKVHVLTHALHYSTSIFEGIRCYNTPNGSAIFRLPEHVDRFFKSAKLYSMKMQFSKKEISDGIIKTVKASGLKECYIRPLAYYGYGTMGLTPTQNKVDASISCWEWKMGESKAGKFSGAKCKVSSWIKIDSRSQPTQAKAASNYANAALARMEALENGYDEAIMLNWHGKVAEGSAENIFVVKDDIIQTPPLSAGGLEGITRDSVIQIIEENGGFVIERDLERDDLYAADEIFMTGTAAEVKSVTQIDKVKIGNGKMGHITKALQKSFTDVVMGKDERFLPWLTYI
The following text describes a protein:
Function:
Peptidyl-alpha-hydroxylglycine alpha-amidating lyase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides. Mediates the dismutation of the unstable peptidyl(2-hydroxyglycine) intermediate to glyoxylate and the corresponding desglycine peptide amide. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
Sequence:
MATPTVAILGLVLLTGALAGPFERQQNAQLYDEVRQLLSLAQGYQAGVQNDAPSEQASDKPDVPRAVKNWPKKPLKLGQVSGVSVNSAFQPVIFHRADRVFDQYTFNSTNHFQQLHLGPIAEPTVLTLDPQTGQVLGQWGENFFFMPHGLTIDRHDNLWVTDVALHQAFKFKPGELSPILTFGQRLTPGSSKNHLCMPTSIAVASEGEVFIADGYCNSRILKFNAAGVLLRIIPSPPEFLSLQVPHGVALIESLDRLCVADRENMRVTCPRAGLYSMKGKSEPALTIQQPDMGRVFGVAAKGKLIYAVNGPTNQLLPVQGLTIDPQAEAVIDHWAPEEGFGNPHAIAVCPNGSALYVAEIGPNRIWKFELVPPKKK
The following text describes a protein:
Function:
Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Subcellular Localization:
Periplasm.
Sequence:
MMTKIKLLMLIIFYLIISASAHAAGGIALGATRIIYPADAKQTAVWIRNSHTNERFLVNSWIENSSGVKEKSFIITPPLFVSEPKSENTLRIIYTGPPLAADRESLFWMNVKTIPSVDKNALNGRNVLQLAILSRMKLFLRPIQLQELPAEAPDTLKFSRSGNYINVHNPSPFYVTLVNLQVGSQKLGNAMAAPRVNSQIPLPSGVQGKLKFQTVNDYGSVTPVREVNLN
The following text describes a protein:
Function:
Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Midbody.
Sequence:
MATGDLRNNLLKFQSELKLLKYSTSVDLFGASRGDPAVFLPIIHHILLNYSGILARYFAEQSFDLYGKKDARFMESVYSLLRDEFNYKPSISRDQFFAMGFAERKLIFICDMGRMCRELVVSLKRTSRSNGQSKASSVHGGSLFTNGQSTHSLAVPEPIVHSHCHASRPFSSHHASSSLGSAHSGLKESPSVWTADTLHFSTNGSMGSLNKKPTPTQTHPNYVYVQQHQAVNTQVPQSNISQTVDNHSISLNQYRVFEHGHDTELEAIYDESIVHEPQIPPAPAPAPNPDLIPILLEQPPTQNTATASTGMPPQQLLNSFIIGQSQHTPTKNNHGNHSAAPRSILKTSPQKSPIRSDTNHSNFTSSSQVDIQTRSMRLSPKKFRIVESISQDEHLASYRYYPLEWGQRDDYPSTFIGERLVDTPKANINSCRIDGDAGARDILFPDSPSEKEPGSPTKPSDAGHLENPAIFDHSTVGETPISRKEFEDMTASLKTMTSKNTELEKITQTLVQRIEAMQHQINSLLDSRTKHQETLDVIPSNVLASDLNVQPAVPNQRKLEHHKPLFVEPINTDAAPISSARLDISQRILNIQQRISDTSRLLNQPAASVLH
The following text describes a protein:
Function:
Catalyzes the trimethylation of 'Lys-116' in calmodulin.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MERNCTTAEKRKPASPLRRKSTNADTCSARAETCDANDVARARWTLLRQVLRQKQLESPEIQQVSVRRFATFDLFSRELLEAKDVCDTSDAQWVEYRSVHFPEYSALLRDNLGPVRVNEVLNSFDNTGNICVWPSEEVMAHYCLQKRHTFKGAVCELGGGMTCLGGLMVAISADVKEVLLSDGNEKSIQNVQEVIEKNKQAGKFGSTHVSSRVLRWDCEKDISAFEDHFDVIMCADCLFLDQYRASLVDAIRRLMHPKGMALVFAPRRSETLSLFCELAQQAGLCVSQHQQYDAQVWDVHLKMQREGKQVYDENIHYPLLIILTKGPQPFSHSQ
The following text describes a protein:
Function:
Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.
Subcellular Localization:
Cell junction, focal adhesion. Cytoplasm, cytoskeleton, stress fiber.
Sequence:
MASKQEKRVASSVFITLAPPRRDVAVTEEVTQAVCEARRARPWETLPTKTPGAAVGRSPKTWTPSGRTTASLPEVPPQLSNGGCSLPPPPLNEEDLDLLPPPPPPPSAYLPLPEEEPPVVPGSSLISDLEQLHLPPPPPPPLLQAPSKGSSVQPQPVQVRPSEEELPPPPEEPVTLPEREASTDVCGFCHKPVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQRFYQKDGRPLCEPCYQDTLEKCGKCGEVVQEHVIRALGKAFHPPCFTCVTCARCISDESFALDNQNQVYCVTDFYRKFAPVCSICENPIIPRDGKDAFKIECMGRNFHENCYRCEDCSVLLSVEPTDQGCYPLNDHLFCKPCHMKRSAAGCC
The following text describes a protein:
Function:
Probable RNA helicase required for post-transcriptional gene silencing (PTGS), a process that provides protection in plants against virus infection and can suppress expression of transgenes. Plays a central role in RNA interference (RNAi) process, a process that mediates mRNA destruction of translational repression. Required for the assembly of the RISC complex, a complex required for target RNA destruction or repression. May be required in the RISC assembly to unwind miRNAs, in the production of single-stranded miRNA from the double-stranded miRNA, a key step in RISC formation. Involved in the amplification of sense-PTGS (S-PTGS), leading to siRNA production. Required for the maintenance but not the initiation of tobacco rattle virus (TRV)-mediated silencing, probably by mediating/maintaining DNA methylation and chromatin-based transcriptional gene silencing at some genomic locations.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVSGYKSDDEYSVIADKGEIGFIDYQNDGSSGCYNPFDEGPVVVSVPFPFKKEKPQSVTVGETSFDSFTVKNTMDEPVDLWTKIYASNPEDSFTLSILKPPSKDSDLKERQCFYETFTLEDRMLEPGDTLTIWVSCKPKDIGLHTTVVTVDWGSDRVERVVFLLAEDKISSSLTSNRPYSRSRRAPKKDFAVDDYVKGSRPSKVVERSFRNRLPLYEIPKEIREMIENKEFPDDLNEGLTARNYANYYKTLLIMEELQLEEDMRAYDMENVSMKRRGIYLSLEVPGLAERRPSLVHGDFIFVRHAYDDGTDHAYQGFVHRVEADEVHMKFASEFHQRHTAGSVYNVRFTYNRINTRRLYQAVDAAEMLDPNFLFPSLHSGKRMIKTKPFVPISPALNAEQICSIEMVLGCKGAPPYVIHGPPGTGKTMTLVEAIVQLYTTQRNARVLVCAPSNSAADHILEKLLCLEGVRIKDNEIFRLNAATRSYEEIKPEIIRFCFFDELIFKCPPLKALTRYKLVVSTYMSASLLNAEGVNRGHFTHILLDEAGQASEPENMIAVSNLCLTETVVVLAGDPRQLGPVIYSRDAESLGLGKSYLERLFECDYYCEGDENYVTKLVKNYRCHPEILDLPSKLFYDGELVASKEDTDSVLASLNFLPNKEFPMVFYGIQGCDEREGNNPSWFNRIEISKVIETIKRLTANDCVQEEDIGVITPYRQQVMKIKEVLDRLDMTEVKVGSVEQFQGQEKQVIIISTVRSTIKHNEFDRAYCLGFLSNPRRFNVAITRAISLLVIIGNPHIICKDMNWNKLLWRCVDNNAYQGCGLPEQEEFVEEPFKQEGSSNGPQYPPEAEWNNSGELNNGGANENGEWSDGWNNNGGTKEKNEWSDGWNSNGGGTKKKDEWSDGWDNNGGTNGINQEGSSNAPQDPQEAEWNDSGEVKNGGTKEKDVRSDGWNNNGGKNEKEECCDGWKDGGSGEEIKNGGKFETRGDFVAKEEDEWSDGWK
The following text describes a protein:
Function:
Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, ruffle. Cytoplasm. Note=Recruited to the cell membrane via interaction with PACSIN1 (By similarity). Colocalizes with the actin cytoskeleton. Detected throughout the neuron cell body, as well as in axons and dendrites.
Sequence:
MDAPRALAAKPPTGRKMKARAPPPPGKPAAQNVHSEQKLPHDATLGSQQSLVYMKEALQNSTLDITVVLPSGLEKQSVVSGSHAMMDLLVELCLQNHLNPSHHVLEIWSSETQQPLSFKPNTLIGSLNVHTVLLKEKVPEERVKPGLTKAPEKSVRLVVNYLRTQKAVVRVSPEVPLQNILPVICAKCEVNPEHVILLRDNVAGEELELSKSLNELGIKELYAWDNRREMFRKSSLGNDETDKEKKKFLGFFKANKRSNSKAEHLGLSGADSDEDPAKSASGGDLNGCVTTPNSPSLHSRSLTLGPSLSLGNISGVSMKSDMKKRRAPPPPSPKLLGQDKVSEKASLSSQADLQKKKRRAPAPPPPQQPPPSPVVPNRKEDKEENRKSTVGVGRQVPQKPPRGTARGPPQLVLPPPPPYPPPDTDVTEPVTFPGEGAGSETSELRPKLSLPLGPGSHCSMGGVSQVPAESEETASEDTTEDSGVMSSPSDAISLDSQQDSMRSKDKWSTDQEDGSDQDLAGTPELGPQKSPSWGKSGSGSSILRTEKATMPTNDDEDLFITGHLHQTLAELDEDLEGMEENYETDTSSLTNSVNGVSNHSLQEAIIPDSGVDDIPVTFIGEVSDEPFDSGLFSSRCNNATTFNTGSIASQRSHLSPSQTEHSQPFVRTSRKEPDPSPPSQDNRKRNQPTLANTSENENPVETDPTVTSLVSKLLIDDPKAKDKGKVHGSSHSEKTQAGHGINSLRVNPRDGKDESSNSAPPPWSHHGQALGGSYGLKYGLTTYKIVPPKSEMRCYDRDVSLSTGAIKIDELGNLVSPHMNGSRTISPPSAVVETDTPPIGKVKEFWRRNSMEKYLNGPAECTIKRAPSTTITATPEKPQQDNGMKAAFTVTTPQQQPASQEYGAHLEEERSRPQSAVSCSVKVPASNPTDITFLKPQRRTSSQYVASAIAKKMGPPKVHADVVRPHKATTEQCHEEAKLARSPPTRKDDAAPNLHSEARQHEHGTNQSSVCLPSNPGVQLPAGGHPKVEVNSTYGKSSTQDYPAAVHRNSYFLPGRSSHRDRVSVGQSCGFNEKQTTSNQKANSTSNFSQALDKAHPPPLLLAEARDSGRILMNGSARTPGNCEPPHSPKESTLTSYIILQTEEKPSSLSTDGQDADDTLPSSIFGPKKKFKPVIQRPLPKDVSLHSALMEAIHSSGGREKLRKTAEQTSEGRPKKPSYVEAESERSALLAAIRGHSGTLSLRKVSSLASEELQSFRNAALGAPGLDKPQQEDLGLPPPPALPPPPAPAPQAPSASVTVSRFSTGTPSNSVNARQALMDAIRSGTGAARLRKVPLLV
The following text describes a protein:
Function:
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAVHDLYGDNKSNWQLVLDVLSWIFWSNATILLNKWIINSTDFPIILTCWHSVFATIVTQVLARTTRLLDGRRSMPMDARMYCRTILPIALLYCGTLVCSNVVYLYLNISFIQMLKAAGPVVTLITSWSWKVAKPSIGAFINILIITLSVAMAVSGEIRFSWLGFGFQFASLVFDANRLVMVQILLSDSGQKMDPLVSLYYFAPACAVMTSLVAWQTEYASFEWSSVAQAGWTVLSLSAVMGFMLNVSIFLLIGKTSGLAMTLISIPKNILLIAISVVLWHTPISLLQILGYSIALWSLLFYSIGWKTVKAYIDALGVWSRKSDENEVLLSDRV
The following text describes a protein:
Function:
Uptake of arginine from the medium in exchange for ornithine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVEFEPRSYEDFDPEKRPSFGQALLPIAGMITFLAVGIVLLGLDAQMPLLWGIAFTGVIARYGWGYTWDELFDGISNSIVMGLGAIFILFIIYMLIASWVDAGTIPFIMYWGLEFLTPAVFVPLAALLSFVVATAIGSSWTTAGSLGIALVGIGSGLGIPAPLTAGAILSGVYMGDKQSPLSDTTLLASGVSDVDLWDHVRGMFPNTIIVGVISLALYAVLGLMAETGGTGGTGAEVAQIQGGLAGTYTLSVLVLLPLVITFGLAIKGYPALPSLGAGVFSAAGVSILIQGRGFAEAWQIIYSGTGPKTGVDLVNNLLSTGGLEGSIWVITIVFGALSIGGILEATGVLSVIAHNTAKAVDSVGGATLVTALGPLVINALTADQYMSIVIPGMTFRDLNDEYDLDGTSLSRTLEETGTVSEPMIPWNSGGVFMASALGVPVLSYLPYYFVGILSPILVVIMGFTGWKMYMKDPEESPEESADTAA