lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLVVNAGLCTPLGQCPLLVPLFEVQLGSAAAVKKRADRSDLQKPDLYRRKCPMGKACLPCKKDEYTEYPNDFPKCLGCRTCREDQVEVSPCIPTRNTQCACKNGTFCLPDHPCEMCQKCQTECPKGQVRLAPCTQHSDLLCGPPLEISSSSSTLWIIITFTVLLAVILGLVLVFWKRCSSRHHGAGDDGELSWKPSAVVNRLLQRLGIQDNRCNEQIYQNQQQQELLFTAQGSEVPHGVEMEGTERRTPDPKVETQRKLVPVLGENPIALLHRSFNTFVDYVPFPEWKRFGRALDLQENDLYLAEQHDRVSCEPFYQMLNTWLNQQGSKASVNTLLETLPRIGLSGVADIIASELISKGYFQYEVS
The following text describes a protein:
Function:
Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Sarcoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
ASPRPTGSPGGGRWNWAGLLLFVCDSCFCTSSLSLTFPNIAKHGGHKNGRRGGISGGSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLGKLGVYDADGDGDFDVDDAKVLLGLKERSTSERTFPPEEAETQAELEEQAPEGAEAQNVEDEVKEQIQSLLQESVHTDHDLEADGPAGEPQSEVEDFLTATDSDDRFEALEPGTQNNGTDKKQIKWKFSLSLSLSLSLSLSLLSVKKKKPKLLNKFDKTIKAELDAAEKLRKRGKIEEAVSAFEELVRRYPQSPRARYGKAQCEDDLAEKQRSNEVLRRAIETYQEAASLPDAPTDLVKLSLKRRSERQQFLGHMRGSLLTLQRLVQLFPSDTTLKNDLGVGYLLMGDNDSAKKVYEEVLNVTPNDGFAKVHYGFILKAQNRIAESIPYLKEGIESGDPGTDDGRFYFHLGDAMQRVGNKEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPRETGYTELVKSLERNWKLIRDEGLMVMDKAKGLFLPEDENLREKGDWSQFTLWQQGRKNENACKGAPKTCTLLEKFSETTGCRRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANETRSWEEGKVLIFDDSFEHEVWQDASSFRLIFIVDVWHPELTPQQRRSLPAI
The following text describes a protein:
Function:
Catalyzes the coenzyme F420-dependent oxidation of hydroxymycolic acids (H-MAs) to ketomycolic acids (K-MAs), a lipid class making up the mycobacterial pseudo-outer membrane and over one-third of the dry weight of M.tuberculosis. Does not exhibit F420-dependent glucose-6-phosphate dehydrogenase (FGD) activity.
Subcellular Localization:
Cell envelope. Note=The Rv0132c-F420 complex is translocated via the Tat pathway across the cytoplasmic membrane, where Rv0132c is anchored to the cell envelope.
Sequence:
MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSHEQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVGNSTSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGERLNEQAATDTFGNYRERHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKLYDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQARDINDAKLLAAFAAGAQAAGRDPTTLGKRAELFAVVGDDKAAARAADLWRFTAGAVDQPNPVEIQRAAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGAVPFLHFPQDDPITAIDFYRTNVLPELR
The following text describes a protein:
Function:
Plays a role in vesicular protein sorting.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MEEDQEKYLEDARKVVKEQAYFMRASLEKAQLKDALRYSSAMLSELKTSLLSPRNYYILFMQVFDEMRILENYFKEEYRRGRKMPDLYESVQHATYVIPRLYLLITVGSVFIQTHEIGAKVILLDLLECIKAIQHPLRGLFIRYYFLKLCKDRLPDTGSEYEGTGGNIDDAIEIIIRNLSEMNKLWIRMQGSKDKSKRERERLDLKVTIGENVTRLSNLEGVSLDTYKTKVLPKIIDIITSSKDAISQTYLMDCTIQAFPDEYHLQTLQELLKVCTTQLEPTVDIKNIFINLMGRLADFALNNDMGTFNSEVDIYSMFKQNIDKMLDSNSQIEFKNLLDLQVAFLNFTLRCYPNNSEYVNDILKSCCRLCERQNETDFTEECQKNIVKFLAMPLDTMSLSILTMNEYPNLMKHLPFQKRRQVAIKICQAVVNLNQVIDDLKITGELLKFIQPLLITQNDYVEIPENEFEEEQQLVARTVHLVQNGDLAIHNTILQQFIAKFQQGEINRQKYTYPAAIFALFRLIQLIAAQGGPQTQETQYKGLFEQIRGLIEVLQGHFPELALKLNLNFLLCINIVDQAQEFDEFSYDVGTQIITIFQDEIGDSNVKVVLLNQIMSTFAKLNCISGENFDTLAGNATQQAAKLLKKNEQAIGVLNSAHMFYNDHIKNVQRVQECFKKAIKIANQSIGNNPKFVYVFIQILNKYFYFFEQVEFKDAEIQEVIKMINEKLPKALSDNDEQSKKIKILWTATQELVRERKRRSIQAYQQINI
The following text describes a protein:
Function:
Putative phospholipase (By similarity). Involved in the regulation of cellular plasticity in imaginal disks.
Subcellular Localization:
Secreted.
Sequence:
MLKVVGASWQKTRIGTYILIGAGLLVIGAFFIGYMERPEYDGTYCATALWTKQVGFQIENWKQQNDLVNIPTGVGRICYKDSVYENGWAQIEVETQRTYPDWVQAYAAGMLEGSLTWRNIYNQWSNTISSSCERDESTQKFCGWLRDLLTTNYHRLKRQTEKAENDHYWHQLHLFITQLEGLETGYKRGASRARSDLEEEIPFSDFLLMNAAADIQDLKIYYENYELQNSTEHTEEPGTDQPKNFFLPSATMLTKIVQEEESPQVLQLLFGHSTAGSYSSMLRIQKRYKFHYHFSSKLRSNTVPGVDITFTGYPGILGSTDDFYTIKGRHLHAIVGGVGIKNENLQLWKTVDPKKMVPLVARVMAANRISQNRQTWASAMSRHPFTGAKQWITVDLNKMKVQDNLYNVLEGDDKHDDAPVVLNEKDRTAIQQRHDQLRDMVWIAEQLPGMMTKKDVTQGFLVPGNTSWLANGVPYFKNVLELSGVNYSEDQQLTVADEEELTSLASVDKYLRTHGFRGDLLGSQESIAYGNIDLKLFSYNARLGISDFHAFAGPVFLRFQHTQPRTLEDEGQDGGVPPAASMGDERLSVSIEDADSLAEMELITERRSVRNDMRAIAMRKIGSGPFKWSEMSPVEEGGGHEGHPDEWNFDKVSPKWAW
The following text describes a protein:
Function:
Cleaves double-stranded RNA (dsRNA).
Sequence:
MAPPPAMKPASRKRGPPAPDPVELPPPGFVADRAEAAARVERLLRYQFRDGRLLEEALTHQSFADDAVSYQRLEFVGDSALGLAFSNFLYLTNPTLGPGPLSTLRAANISTEKLARVAVRHDLYPLLRRNCPRLDLLVGQFIETVKQEPEDDLSTVPYGGSVVKAPKVLADIVEAIAAAVYVDCKFDLEKLWKVTRWLFEPIITAETIDEQPVTMLHELCQKHGKMAQFKTWQKGGMTVVNVFVAGELVGIGSSEQKVIAKLNAARDATRKLAGAKKQVLTTGVGNGLGDEIGELRECKQKLNEQCSRQNWPKPIFK
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Deubiquitinates H2BK143ub1 of histone H2B.
Subcellular Localization:
Nucleus.
Sequence:
MRPNTRNKNKRQRPSETVDSSSQILRKMYEANDVTEEEVNHLFMIHKKPLCQGCRVNTRDNPNCFCALVPPPNGTRKSGLWQKTSELIQALGPDLSSHRRASLSSPSGLTNLGATCYANSILQCLYMNSAFRDGVFSLEAEVLQQHPVLDQIARLFAQLRASNRSFVDSDAFVKTLELDNEIQQDTHEFLTLLLSLLERCLSHSAVSKAQTIVQHLFRGRVSHVTSCSKCGRDSEASSKVEDFYALELNVKGLKSLDDSLSDYLSLEHLNGDNQYFCASCDARVDATRCIKLRTLPPVITFQLKRCVFLPKTTAKKKITSSFSFPQVLDMRSRLAESSESELTYELSAVLIHKGSAVNSGHYVAHIKDEKTGLWWKFDDEQVSELESEVFSSSDAYMLIYSLRSSKLESWEGQREDPIDITKGDVDGVQQPEGGYLPPHLDEWISDLNATFLEGCKQFDLRKERELNTLTERRQEVRTILSEAAVQSLEDQYFWISTDWLRLWADTISPPALDNTPLLCSHGKVLASKITCMKRISELAWTKLESKFNGGPKLGKGDYCRECLMDSARMVVSSDSYRDRRTFMKSIATDVLSGKFEDGEYYVSKAWLQQWVKRKNLDAPSEADAGPTNAITCSHGGLMPEQAPGAKRILVPENFWSFLVEDALKVTPEDTSDCPCFPLDSSQCSHCTSELSEVADVEDALRTIKAKQRQNHEKLATGKSIALTPQSRYFLLPSPWLVQWRSYISMTGKNSSSVPDPELLSGVIDTLKCEKHKRLLERLPELVCKRGSFFQKNPSTDKLTIIPEDDWKCFCEEWGGIMENGVSAFTETGNNRHGSASQDVIDLEKDMDIDSQQLILRTSPEVCEECIGDRESYELMQKLSYSEGEVSVSLVRGKEAPKSMLEASDSGLEVDRRTSKRSRRTNYGKQTSLKVSATTTVYNLKMMIWQLLGVMKENQELHKGTQVIDQESATLADMNIFPGDKLWVRDTEIHEHRDIADEICDKKMGHQDIEAGFRGTLLTGDITSEAR
The following text describes a protein:
Function:
Plays an essential role in both non-selective and selective autophagy such as mitophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation, through its interaction with ATG32 (By similarity). Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation (By similarity). Required for ATG9 anterograde transport from the mitochondria to the PAS (By similarity).
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MSEISYLSINNAHNGIIIKIPKPVRFHTLSEFKKYIQQSYSIDSVDNLFLLTTFGIKLNYNLINEIGEVFVYDKRLFTNIVDQSLIDQYTQSTFRVSEPTHSPLLKSNVGFLKQNLSSNLKINQGWARIITQDGELMDQYCRELIQQINVIFKCLNTIFQFATNFTNEIEKNFSNFFNYVKLINYKTLHKSWITNYKNLKTFPTFKIDNENIKLSDFLEVDRLQSSADYIEKFLPLIVNKLNELKQVIETVNEEKLTVDKFIETSRNESISNFKNVNISNVLSQLQTESQQLTDDIENLHYKNMDEIYRLHRDKLSISIYNNAKDIYKNLNDLQQFKNKLTKASLKAFNTIANLQMKMVGVKTEMKKITTEDETATEDSKVGDVNYKTISNVKKYEDYLSLTIDLPLIFGFSLIEKRRQFEWYDFYSKGIVNNVSEQLSTIIEHEKVFRGIWLKKFGTLLSLINDDPLTPSLPNIDVTLVGNRQNNFSILYDLKIERDDIINYISLIEATNMSKNFVTLLNKNFKDLIASTNNMKKVTKVISSLSTYTTNSADDKSKSSHEEGTEEEIDFDLNLIKGLKSRIKKLENLLHQQQFKNLNNWPVIRNVPSMTNDNRQSTIIQPTVVSPARTNPTQLLSRNPSTTKENTTTNIHNNHQQSEVLDSSVIDKHLDNIRLKKLNNELQTKNTELTNQINSKNETITQQQKEMEHMKLKTEKRVDELMKKLQEKDEECQSLKQENKIKCDEVENLTKKLELSDNHNKELEAKITEYTQKATSKTKEIADLNKTVSNLRSELGDAMHMKNDLLSNLSSKEAEFTKERNQFNNDLKALQLKLDEINEDYENLMELTQAKQKKHDLIINDLNNVIINLMNDIKKTLLSVFEYFLEYCLVLESMGLLLVKEDEIYKIKRVKGLKSKKSIGDGDMSIISNGTPSSKVIEEIENEINIVNNIPPISSILPDSYSSGTESDSVVDRYNDQSMKLISTFNQLFKFNNENENENRIDHILNTLAFKNNVQLQEDSINDTRFFLNAISKRFRDVEGFAKRQAKDNKLKEQEHRKLVHRLNSKISVNGFQEKDLVLFLPTRIDRPNGENIPSNDKIQPWAAFNIGAPHYFLKTEQTKNKEWIIGRVKKITEYKVTEENVQSLESNPFQLSVNVTWYLVEADEE
The following text describes a protein:
Function:
Required for cell migration during body enclosure and cell shape changes during body elongation. Plays a role in recruitment of the cadherin protein hmr-1 to adherens junctions.
Subcellular Localization:
Cell junction, adherens junction.
Sequence:
MLLHSTNSYSIFTDHEVETRTSRIRSAMFPDWIPPTSAAEATNSTTSIVEMMQMPTQQLKQSVMDLLTYEGSNDMSGLSLPDLVKLMCDHDESVVARAVHRAYMLSREDPNFFNAPGFDHRSFVEALMAASKSSNVNVRRNAIGALSHMSEQRGGPLLIFRSGGLAEIIRMLYDSLESVVHYAVTTLRNLLMHVSDSRAQARALNAVEALTPHLHKTNPKLLAQVADGLYFLLIDDAPSKITFLSLLGPQILVSILREYSDHRKLIYTVVRCIRSLSVCPSNKPALISLGCLPALYVELCTAKDERSQTAILVAMRNLSDSATNEENLTQLIIKLLEIIRVANDGMTACACGTLSNLTCNNTRNKQTVCSHGGIDALVTAIRRLPEVEEVTEPALCALRHCTARHSLAEEAQSELRFCQAFPVILDQLETLRTPVIKAALGVIRNSALLQTNLIELTQEQTANGHTAVSLTMDILRRAITAIEENPDIAVDGVPMWGVIEGAVSALHQLANHPAVAAACCDDIGQVGNPECPPFLDLLHRLLAHPRLGSMDDEVLEREILGLLYQLSKRPDGARAVESTGVSALLMESRGSQYKSVVTYANGVLSNLKRGDSAAIMNMSNSYDYEMSGSAADWQRDGLERELFAEMYPTNDGGHSESINMALNNSQMRPNHNWYDTDL
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MVIPDIPHITQGLFPLSDIVDAFSRNTLKQLVQLADILPSLSNVDKKRQILQWLIQYRGYAIRILVLSRWAGVAPLVNRCIDVVAYLQGQKFCYQNLIYALQDIRYQLSFARVRNSDLLTAVDVLSSGTYPRLLQTPTSNAYLVPDEEISAKEALKALDAIHATLRLRLHLHETIPRPFRDYEIRDGRCIFVVPNEFSVALSTTSDNIRPENLAFQWFLVDFDFLLPSTSPSTITPERYKNLIEQHLNEQLAVALLNKLPALPLVYDILHRCCLYLRLNLLHQQLEALSRDSWAGHLIGTLNEQTSTLRIKYWPKLKISKDGKVVTPDFEIIISVLTQEPTAYERLLSTRTSSAEYDHSKLNIVWQHDGTSEPISIEEPFESQDLLMLVTKKHAAIFFERIQSNMNKSILSELREDGLVLQMMKHRILLKVNSITGRLVLLDEQQRLAPARYLRAAENTIAAKPDLAAQTLNRLRLFCIQAQMIELSQCARLHVVRGYLPPAYLTFTRLSWHRPDHSVWMLAFHVETLHWFMYLTSATGKVLFSQRVHTTGDALSIQSFSRLAHLVHLRQQLYEIQLVCESKHMRYSYMLTPPGASFQDTFSEFVQTSLLCIEMPEKYGVLYPMVFVRASENKLVFDGRIHYRTPQGKKETSGDCTVDWRVGRFTVQSRNFDEFEKQWVGLSKLAMLAVTTAFEVVEVTLHYVKFRYGDTETFQVSVLENDSFKIQFFNPQSCFHMIAHLLQGVLSDSRNDVRTLRNILDRTHGILIAQSMGFIVLVRSLRSFRILLAPNHGLQVTLSRSGAVIQDLSIAKCEPSKNPADDEALIKWAPCAWLNSVWEGDMDDDELNGQVEASPESCLLRLSKDADLSAVIKHILMLTCKLKAS
The following text describes a protein:
Function:
Crystallins are the dominant structural components of the vertebrate eye lens.
Sequence:
VHFLCFYSYRRRSLEPAKMTTQPMVEQMGQWKITVWEEENFQGKRCEFMMECQNIMERGFHKIRSIKVENGPWVGYEYPEYQGQQFILEKGDYPRWEAWSGNSGYRTEHLLSFRPIRCANHSDSKVTLYECEDFQGRKFEMCDDYPSLQAMGWCSKEVPSIKVNSGAWVAYQYPGYRGYQYILERDRHNGEYRNYNEYSTQAHTNQIQSIRRIQH
The following text describes a protein:
Function:
ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular Localization:
Nucleus.
Domain:
The DBINO region is involved in binding to DNA.
Sequence:
MAHTFRNSYEKTFKVLDNSEAKMHHELNGSTSKPIHVQRVERAVQLNNFLKEVDYQLDENSNSDDSIDISNNFDNLLRESESHSTKDYYNLKHVSQRRAWLAEVLQENADSTPDDAQYKHITKLHTWQKQIRSTKDVDFKRYIYYGSGLLSEIDRYPEIEKSLPVKSVKKRHIKEETSKSPLYPPEILEDISDEPCIGLSLDNVIDFQNLDEDSNVNSDFGQPVSQTSHQTNTSHSSSKKRVKKFKDEESRKKWEDMMKVKRKKIFTNMAKKEIGKQHRSKINKHKEMLIQCRRVAQQCLKYGRQKALQSARTVKEQQWRMKRLSRENIAYWKRSRRFDREVKKRLEKEAEEQRKIDHELIEAKRQQRKLNFLITQTELYAHFMSRKLGKASPEEQLRILSQLDEEQSSRLLNIDDYDSEVMKEKAKRNAQEAFQNEKVRTRHFDIEAKSSVDVNAIDGEQPQPSIFQGKLKGYQLRGMNWLANLYAQGISGILADEMGLGKTVQSIAFLCHIAERYSVWGPFLIISPASTLHNWQQEIAKFVPNFKVVPYWGNPNERKILRQFWDQKDIYTKDASFHIVITSYQIVITDIKYFNRIKWQYMILDEAQAIKSTSSMRWKTLLGFSCRNRLLLSGTPIQNSMAELWALLHFIMPTLFDSHEEFNEWFSKDIESHAENKTGIDEKHLSRLHMILKPFMLRRIKKDVENELSDKIEVMVYCPLTTRQQLLYMALKQKIKIEDLLHYSVGGGDSHTVDKNFTSNLMNLVMQFRKVCNHPELFERRDAKSPIHIAPCVFRIPYLIYDFNVTAVLMLTLQKYFVFTPGYIAEAVKNDFNTLFRVHSFLNLSFYELYMILQGDVRTRWTHFFRSENEDEILYHRYFWNEGSTKPSMRISYKFKLTNANIRTSSILPELIFTRKNSGSRVFYTHTDQYYYPMPETVEHRNIRCKNALNNEEDAIIDVVADESPLTEEVKSEGGEAGTYRDETPRIQKHALTDLPSFLFCTMPKVTTIFPNLYCYSRRVAWLIRRHNYEFSYNSLNHYWSEATGHRNRKPAETLYPQPTNAIDVLRPLKGWSYIAIPDKETLVTDSGKLSVLDGLLKRLKEEGHRVLIYSQMTKMIDLLEEYMWHRHHKYMRLDGSSKISERRDMVADFQARTDIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGSIEERILQRAREKSEIQKLVISGGNFKPDTLKPKEVVSLLLDDAELIHRSEKLRVDFNKTKDEDKELEKKRKHMLAFKTIPAVPELKKTKSDSSQETYIEDWSSTLDSGPSSPHSANSPDVLTDDMAESGYGEEDSPITNKYTVYNVYGSTVKPRIPGRGGSRRGRPRGSRRMSSLGRTNSSISSTSTNGENEYSTNSQSTLASPTSNNYLNVPLGASGSQSPNLAIRRGPGRPRLKPTGPPNTGSRGTYRPRKPARPLPVPLPSDGSNVSCSTSGASATPSYSTYLYDLPDQDS
The following text describes a protein:
Function:
Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAEEVFSKLRSNSEQNCDEAVRLLVKIAENIVKDPANLKVRSLQKSNSTIKNKILSVKGGSECLKLMGFQENESSFTLPSTTSMEKLQEVKKCLLNFKNDEKRQGAVPKLKQETMIRSNSTNFEVNGDDLDNVKRFVLPTLKKLFTNPFLQRIETEFHRALAFDDKECQKRAKKLIPLDRLEKNAQRNLRYVQTRIKNERVQDPEFSVQDMLLIELLKWFKEEFFSWVDSPGCEKCGGNTAMSHMSSDKTDLVYTSRVEVYKCKTCNAFTKFPRFNDLNILLETRRGRCGEWANVFTLLCRSLGWDARYVVDELDHVWTEVYSVTQKRWVHCDCCENACDTPLMYETGWNKKLTYIIAYSPDEVQDVTWRYSSNHREVRTRRNKCSEDELVNALITLRNERQKSFSAPKRDYLTKRLVTELIELMVERKANDSEKFGRISGSKEWRSARGEIKNENMYVWIVPSKHIVNNKLTIKYSTAFDKYEFVKGDNSVLGVNGWQYGVYDFSNVFRKEEKDWKTVYLARNEGTDQGSISWRFELDKGVKKCIDNLSLKFNYQLYESGVVQIQLISDDKCVDFPKTEGALETQAFSGVRHFTIKATLSGGKGNVAWQHAQLFRQSSDSKDFPFVLSVTFRNVE
The following text describes a protein:
Function:
Encapsidates the genomic RNA, protecting it from nucleases (Probable). Displays high affinity for single-stranded nucleic acid. The encapsidated genomic RNA is termed the nucleocapsid (NC) or ribonucleoprotein. The ribonucleoprotein has a non-helical structure. Serves as template for viral transcription and replication (By similarity). After replication, the nucleocapsid is recruited to the host Golgi apparatus by glycoprotein Gn for packaging into virus particles (By similarity).
Subcellular Localization:
Virion. Host cytoplasm. Host nucleus. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus.
Domain:
The N-terminus is involved in homooligomerization.
Sequence:
MDNYQELAIQFAAQAVDRNEIEQWVREFAYQGFDARRVIELLKQYGGADWEKDAKKMIVLALTRGNKPRRMMMKMSKEGKATVEALINKYKLKEGNPSRDELTLSRVAAALAGRTCQALVVLSEWLPVTGTTMDGLSPAYPRHMMHPSFAGMVDPSLPGDYLRAILDAHSLYLLQFSRVINPNLRGRTKEEVAATFTQPMNAAVNSNFISHEKRREFLKAFGLVDSNGKPSAAVMAAAQAYKTAA
The following text describes a protein:
Function:
Transports pantothenate into the cell. Also involved in the catabolite repression-mediated regulation of ergosterol biosynthesis and in fenpropimorph resistance.
Miscellaneous:
MISCELLANEOUS: Present with 3060 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMKESKSITQHEVERESVSSKRAIKKRLLLFKIDLFVLSFVCLQYWINYVDRVGFTNAYISGMKEDLKMVGNDLTVSNTVFMIGYIVGMVPNNLMLLCVPPRIWLSFCTFAWGLLTLGMYKVTSFKHICAIRFFQALFESCTFSGTHFVLGSWYKEDELPIRSAIFTGSGLVGSMFSGFMQTSIFTHLNGRNGLAGWRWLFIIDFCITLPIAIYGFIFFPGLPDQTSAVSKFSMTRYIFNEQELHYARRRLPARDESTRLDWSTIPRVLKRWHWWMFSLVWVLGGENLGFASNSTFALWLQNQKYTLAQRNNYPSGIFAVGIVSTLCSAVYMSKIPRARHWHVSVFISLVMVIVAVLIRADPLNPKVVFSAQYLGGVAYAGQAVFFSWANIICHADLQERAIVLASMNMFSGAVNAWWSILFFASDMVPKFERGCYALLATAISSGIVSVVIRSLQIKENLSKKQVPYIDANDMPGEDDDDDNQDNENDGDDESMEVELHNEEMAEISNPFR
The following text describes a protein:
Function:
General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).
Sequence:
MKIMEPEIKIVNVVVSTKIGDNIDLEEVAMILENAEYEPEQFPGLVCRLSVPKVALLIFRSGKVNCTGAKSKEEAEIAIKKIIKELKDAGIDVIENPEIKIQNMVATADLGIEPNLDDIALMVEGTEYEPEQFPGLVYRLDDPKVVVLIFGSGKVVITGLKSEEDAKRALKKILDTIKEVQEL
The following text describes a protein:
Function:
Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNNQGFLGVNSDQAKSDATKSVNIGKDVDAGTLGNLNKIAKSNEIKDPHPLSDKELAENAQLRITLLGISMESFLFICVNENGVKFPVELAGIAHTNITSSSPIIRNLFIDFFVENLLDKQFLLRIHTKSPNGYVGTLTQGNRDIGATMLIKGIVRFNSLTSNYLSKPNHFQALETTAKRQGTGIWADTNYKEIRTKPFPAQILAIPSSNTFTIINESGDEELFYLSTVHCPDFSFNGISEPFGFEAWNFIRETVIGKEVYITLDDDRADKKFATIKIGNEILNEMLCRKGLALLSINRVRKNSDYIEQIRNAYLYAQENQIGIFGSEIPKPVLVKELNREDRDLLMADEYSRNVRAIIVEVTGSVYLKLFVPSLQTILRVSLVGLVPLQSNDWTSRRAMEVLRRCFLHHEVDVTITRYAEHSRYYRVLIYDSISKLDARVPPVHEGLVHYNKLATDDPSTNKDELEQHAEEARSKSIGIFKSEGRNSSQIPKDKAIPVIITKVIDETTYAVQAQNDNSTKVNELLKADFPQLELLPMEDQYVIMVRNGVNYRAQVVRNRGPEVFVNLIDYGVDVWSFVSDLRKYDDELMQYQPNGFVVSLAFIQPFRNRSKQFTETCLNYIANIFALGNSVYIRRPFDRELPCVMMMMNDTPAAMTLQYALVHDGICTVIDEDVHQLFLPVVKELRKVMANAKENKFGGWSLQESLI
The following text describes a protein:
Function:
Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. Lacks antibacterial activity against Gram-negative bacteria.
Subcellular Localization:
Secreted.
Sequence:
MKVDQMFDLDLRKSYEASELSPQASIIKTTIKVSKAVCKTLTCICTGSCSNCK
The following text describes a protein:
Function:
Flavoenzyme involved in polyamine back-conversion. Catalyzes the oxidation of the secondary amino group of polyamines, such as spermine and its acetyl derivatives. Substrate preference is thermospermine > spermine > norspermine > N(1)-acetylspermine. No activity detected when putrescine or spermidine are used as substrates. Plays an important role in the regulation of polyamine intracellular concentration (Probable).
Subcellular Localization:
Cytoplasm.
Sequence:
MVAKKPRVVVVGAGISGLAAAHRLCGAGGDRFEVAVVEAGDRVGGRILTSEFAGHRVEMGATWVQGVVGSPVYALARDAGALGEEEGRGLPYERMDGFPDRVLTVAEGGEVVDADTVAGPIEELYRGMMEAARAGEAGGGGGVEEYLRRGLRAYQAARSAGGGGGGGKELEEVDEALLAMHINRERTDTSADDLGDLDLTAEGEYRDFPGEHVTIPGGYSRVVERLAAALPPGTVRLGLRLRRLKWGGTPVRLHFADGAPPLTADHVILTVSLGVLKASLGNKDTAGVGAAAIAFDPPLPPFKREAVARLGFGVVNKLFMEVEAVAPSEPEDVAGVQPAAAGFPFLHMAFRGHVSKIPWWMRGTESICPVHAGSTVALAWFAGREAAHLESLPDDDVIRGAHATLDSFLPAAPRWRVRRIKRSGWATDPLFLGSYSYVAVGSSGDDLDRMAEPLPRGPDAAADERPPSPRLLFAGEATHRTHYSTTHAAYLSGVREANRLLQHYRGGANHTT
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).
Sequence:
MDLFSHLNWYSGDFMNEDGEPIKSIPSGKLILVSDTLESEGSFLIHYFLQSIFKATTSTNSSTNNNNSNNSGGVGGGACLLGLNQSLYNYFNVGRKLGYNLTTEYNKGNFTFINGLSTPYKWIIEQRLQQLEDQGIDEEPQLDSISQGFNPFPTIHLIDNKNITSSSSSSSYSNSNNKNKNNNELKDILYKIYNEFINDHKKRVMNNNNNSKTLFIIDGLNLLESHYSTNPSGSNMDILNFLQYCHNYIKENSTTCSMIILYHSDCDEDSKFFNLLQYESDLTINITGLKSGYSKDIDGQLNFIQKDEKNNTFTRVNPIHYQALDNSIRFFSMGSRIQ
The following text describes a protein:
Function:
Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (By similarity). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTMEEMKTEAEAASMVSMPLYAVMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIIMKILEKKSVEVNFTESLLRMAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELLDTVNNVFKKYQYQNRRALEHQKKEFVKYSKSFSDTLKTYFKDGKAINVFISANRLIHQTNLILQTFKTVA
The following text describes a protein:
Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MASSALQVFGFTLGVLAWVGMIGTCASPEWRKNSHGQTLIDNTLKYEGLWVSCTAFVTGQTNCKDYAEFFVNLPQVLQICRALMISSIGTGFVAIIITVLGMKCVGLGSSNHIVKARIALLGGLLFGISGVLTGAAVSYYAQGVLQDYYNPSFAQGLTNVP
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSWITPDLIEILLSILKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQLVADMIKMFFKEDWIPKFSDRVIFTLAPMIAFTSLLLSFAIVPVSPNWVVADLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTVSYEVFLGLSLMGVVAQAGSFNMTDIVNNQAHLWNVIPQFFGFVTFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGEYIGIVTVSALMVTLFFGGWHGPFLPPFVWFALKTAFFMMMFILIRASLPRPRYDQVMSFGWKVCLPLTLINLLVTAAVILWQAQ