lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Sequence-specific, DNA-binding protein required for Tn7 transposition. Recognizes sequences necessary for recombination at both left and right ends of Tn7 and, together with TnsA, forms the transposase. TnsB executes the 3'-DNA strand breakage and joining reactions. TnsB binding introduces DNA bending. There are 3 DNA-binding sites in the left and 4 in the right end of Tn7; as TnsB levels increase more TnsB is bound, suggesting high protein levels contribute to transposon immunity (Probable). Binding of TnsB to the transposon right end represses expression of the downstream transposition genes. TnsABC + TnsD promote high-frequency insertion of Tn7 into a specific target site known as att-Tn7 whereas TnsABC + TnsE promote low-frequency insertion into many different sites.
Domain:
Has 4 domains separated by linkers; DNA-binding domain 1 and 2 (DBD1 and DBD2), a catalytic domain (CD) and the C-terminus (not resolved in structure 7PIK). Binds 21 base pairs (bp) of double-stranded (ds)DNA; binds adjacent sites with a beads-on-a-string architecture making filaments. The CD of 1 subunit interacts with DBD1 of its own, the preceding and the following subunit. Contacts dsDNA via DBD1, DBD2 and the linker between them.
Sequence:
MWQINEVVLFDNDPYRILAIEDGQVVWMQISADKGVPQARAELLLMQYLDEGRLVRTDDPYVHLDLEEPSVDSVSFQKREEDYRKILPIINSKDRFDPKVRSELVEHVVQEHKVTKATVYKLLRRYWQRGQTPNALIPDYKNSGAPGERRSATGTAKIGRAREYGKGEGTKVTPEIERLFRLTIEKHLLNQKGTKTTVAYRRFVDLFAQYFPRIPQEDYPTLRQFRYFYDREYPKAQRLKSRVKAGVYKKDVRPLSSTATSQALGPGSRYEIDATIADIYLVDHHDRQKIIGRPTLYIVIDVFSRMITGFYIGFENPSYVVAMQAFVNACSDKTAICAQHDIEISSSDWPCVGLPDVLLADRGELMSHQVEALVSSFNVRVESAPPRRGDAKGIVESTFRTLQAEFKSFAPGIVEGSRIKSHGETDYRLDASLSVFEFTQIILRTILFRNNHLVMDKYDRDADFPTDLPSIPVQLWQWGMQHRTGSLRAVEQEQLRVALLPRRKVSISSFGVNLWGLYYSGSEILREGWLQRSTDIARPQHLEAAYDPVLVDTIYLFPQVGSRVFWRCNLTERSRQFKGLSFWEVWDIQAQEKHNKANAKQDELTKRRELEAFIQQTIQKANKLTPSTTEPKSTRIKQIKTNKKEAVTSERKKRAEHLKPSSSGDEAKVIPFNAVEADDQEDYSLPTYVPELFQDPPEKDES
The following text describes a protein:
Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Subcellular Localization:
Nucleus.
Sequence:
MAHTAAMHTGPPPAAPTNVGNSPSHTTMAMPGAAARIARTGYIYDPLMMLHCMEGYMPTAENVMDNGDGHPEDPMRIKRIFTRLAEQGLIRRMKRLDFEEVKFEQVLLVHGEEMWDKVQATELLSDQQIQDMKEYYDQLSLYVCRETAHCARLSAGGVIQACRSVCKNEVRNAFAIVRPPGHHAEPNEHMGFCFFNNVAVATREMQREGLAKKVLILDWDVHHGNGTQRAFWHDGDVLYMSLHRHEGGTFYPNSDFGSLNMVGDGEGVGKSVNIPWPGPGFGDADYIYAFQRIIMPIAYEFDPDLVIISAGFDAADGDMLGQCRVTPAAYGHMTHMLSSLAGGKLVVALEGGYNLRAISDSALAVARVLLGEIPPELGIMRASEAATEVVYQVALEQSKYWKCIDVKACEPPEVTELENGTSPVYTIPDLLKIHRAHHMFTKHQLYQIPLASQELEAAFGGQIICNENMYEVGEKGVLVVFVHDFGNLRVETDGARSTNIHLANSYLLDTSDAVVSWVKTKGYNIIDVNILKQLPTEYPEGPKMVVKQANDMESKLMKYIWDNYIELSECEKVVFIGHGTGCQAIMDLVNARDVELKVKAVVQVAGLHSLVRPNPSNKEKLSWFKQCNQIYVPAEHVVLEDEKVKRRLGDAVFTSQKAKVVDVLNDVLPRIKAFVESKVEDGLAPRAHSGLDGLYGLGGAGAGGELVVVNGHVHVG
The following text describes a protein:
Function:
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
Subcellular Localization:
Cytoplasm.
Sequence:
MSIFKGSGVAIITPFTNTGVDFDKLSELIEWHIKSKTDAIIVCGTTGEATTMTETERKETIKFVIDKVNKRIPVIAGTGSNNTAASIAMSKWAESIGVDGLLVITPYYNKTTQKGLVKHFKAVSDAVSTPIIIYNVPGRTGLNITPGTLKELCEDKNIVAVKEASGNISQIAQIKALCGDKLDIYSGNDDQIIPILALGGIGVISVLANVIPEDVHNMCELYLNGKVNEALKIQLDSLALTNALFIETNPIPVKTAMNLMNMKVGDLRLPLCEMNENNLEILKKELKAYNLM
The following text describes a protein:
Function:
Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.
Subcellular Localization:
Endosome.
Sequence:
MASIEIPPEDRQHIDYLADLFAVIIAIEQIEKANRRDLINPNQYDSTVRRLLEKYKNTVAHLQGARNPYFTTIDDFFDKYCARCLAARATIRDGPMSRPTENNARFLARQSVECSDHFITLLDSLRLQQTSVDVLNPPLGDLLQVLRKLGLSKEDFYMRLHNWQRRLDSMSAADMLDESAARDFAYDLDRGYACFKAFLESDPTLSTRR
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAAPTAATDTGIISLRELIDFIAHVADCYPTITKEFPQQLMDILTQHHLVLEPELREKIVGSLVLLRKKELLDSATLLQTLFPILITTPSKTLRALIFQKILMDLRSSNAKTTNHKLNRTMQTVLFNLVTSDRTSSKGLWAIKLTRELWKRQIWTDAKAVEVMKEACLSENEKVIVGGVRFFLGGDKEREEMEDESSDEETIDLARVKHQVGINKKTRKKSRAVEKAKAIVKKRERKKNQPHPLNFSALHLLHDPQGFAEALFAKHLQNTKSNLNLEQKLLVLQLVSRLVGLHRLHIMHLYSYFQKYLTPRQASVTSFLASLAQASHDLVPPDVLEPLVQKIANEFVSEAAASEVATAGLNAIREICARQPLAMNETLLQDLVMYRKSKDKGVVMAARGLLSLYRDVGADMLKRRDRGKEASMSLRAGEKKERRFGEQQTGEIEGLELLEKWKEEERRKRRIEKGLPSDAEDDEDDEAEDDAAWERWNIEEDEDSDDSGGWIDVESDAEIELSDSDDDESPPAKKAKQGDEEEGKAKSETAKPETKKTNLATTRILTPADLAKLAELRSEAAVNSLLPKRLRSDQKNGPSRHADDPLTAAEIEGLAALSAGKATREERIAHAKEGKDRSEYKSVTARRKERKEAQGKSTTNKEKARRKNLFMTLGKAKSKNKRSLVETRNILRAHQQRQKRGGRRGNTGS
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MADKHEVSVVGLLKDVDFHIAKGAVLQLRQKEPDSFYDPNVLGLLECDWVSFIQGKKKEIKGEMWGFEESVLVFIDGQPIGGKEDFLKWAQESFNFQDFRSLPLWYAMAKASYKDHLLSLKHEFVYFDIAVGAKSIGRLIIELYSDRLPRTCGNFKSLIAGNLEESERHDPPLKLRYKDSILHGIVPNGWIQGGDIEGGRGIGGESVYGPLFEDEDFSVAHNRRGVVGMANKGRHTNGSQFYITLQPAPWMDTKYVAFGQVIEGLNVLDVLEGQETFNERPKVECRVADCGVLDPERIWQ
The following text describes a protein:
Function:
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Sequence:
MVKSLVVVESPAKAKTIEKYLGKDFKVMASYGHVRDLIPKEGAVDPEDHFKMHYQAIERNIRHMDAIAKALKPCHNLYLATDPDREGEAIAWHVKQMLESRNGLKDKKFSRVVFHQITKKAVQHAIENPRDISMDLVNAQQARRALDYLVGFNLSPLLWKKIRPGLSAGRVQSPALRLIVEREIEIENFESQEYWTIHADCHAQQQPFDARLIEFQGEKLEQFSIVNEKQAHETRDAITQAANGKLTVAKVVKRERKRNPAPPFITSTMQQEAARKLGFSASKTMQIAQQLYEGVNLGEEGAMGLITYMRTDSVTLASEALQEIRQLIEEKYGQENVPEQTRIYKTKSKNAQEAHEAIRPTSAFRTPENLKKYLNSDQLKLYTLIWKRTIACQMIEATLHTVAVDLKAPNAIFRANGSTIVKPGFISVYQETFDDKKKEEESDSKMLPPLEEGQTVDVNEIKSEQHFTEPPPRYTEASLVKALEEYDIGRPSTYASIIATLKNRKYVDVDNKRFIATDVGRIVNRFLTHYFTKYVDYGFTAKLEDELDDIARGEKTWIPVLETFWSPFKNLVDVTEKTVKRSDVTQEKIDEKCPKCSAQLSIRLGRRGRFIGCTAYPDCDYTRNLTEIAAEAQAVLEGRQCPECQSNLIIKMGRYGKFIGCSGYPNCKYMEPLEKPKDTNVTCPKCKKGTILQRKSRRGKIFYSCARYPDCDYALWNEPVAEACPKCGWPILSIKTTKSRGTEKVCPQKSCNFIEAYDGDKPSLD
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome; Forms part of the polypeptide exit tunnel.
Sequence:
MELKVIDAKGQVSGSLSVSDALFAREYNEALVHQLVNAYLANARSGNRAQKTRAEVKHSTKKPWRQKGTGRARSGMTSSPLWRKGGRAFPNKPDENFTQKVNRKMYRAGMATILSQLTRDERLFAIEALTAETPKTKVFAEQVKNLGLEQVLFVTKQLDENVYLASRNLPNVLVLEAQQVDPYSLLRYKKVIITKDAVAQLEEQWV
The following text describes a protein:
Function:
Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
NMGEEDTLKYLVKLTQEGQLSLIRKVLSEKENIRNLIKKKHFGKSGDTLLHYAARHGHLEVLKFLMEDTGLDIELHNSDYKTALHEAASMSHRECVVYLIAKGANIDRLKKADWTPLMMACTRRNLDVIKELIENGAKPALKNKDGWNSFHIACREGDPWVIQYLLDTCSGVWKTESKTLRTPLHTAAMHGCDEVVNILLDRCNYEPDYRDSCGVTPFMDAVRNGHISIAKSLMEKHQASFTAVDNLGAQPLHQAAVTAQEDALRFLVEDLGVNVNEKATDIKLTALHYAAKEGHSNAIKTLISLGADLLAKDAKGRSVLHMACAGQHAEAVRILLQAGLSDTEDSSGTTAKHFIKKPDVLKVFEEVLGDPNEPKLN
The following text describes a protein:
Function:
Non-histone protein that probably binds to the inner side of nucleosomal DNA, altering the association between the DNA and the nucleosome octamer; Oncorhyncin III has antibacterial activity against Gram-positive and Gram-negative bacteria at submicromolar concentrations.
Subcellular Localization:
Nucleus; [Oncorhyncin-3]: Secreted.
Sequence:
MPKRKSATKGDEPARRSARLSARPVPKPAAKPKKAAAPKKAVKGKKAAENGDAKAEAKVQAAGDGAGNAK
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MTIFIDLASLEDLYNDLISHIETLRKKKGSEYSVADYQILIGEQRTVEFLSKIVSNETEFLFKECKDSDKDIEGFFNVILTILHKLENEDEINIVSQKIRDSLSAHPTENSQLKIKILTNLFNSFQPKSTQRYDIFFALVKLASDSNNLEFVKYQITDIDSWLEDWNVSIQQKRKLYKLISNIFKEKQRMLSHQFLVKYLQTFTKEDSQEAQEDAVRVCIESISLQELYQSDYLLDLPAVQYLEGSTVSANSLTYELMKIFATEQLDSFLQFQQKNPNFLSTIGLSNDDCLQKIRLLSLATLTSEQSKVPYSLISKMLQIDENEVEMWVINAMEGDLLDAKLDQLNRIVNVNSSTQRVFNKSQWSQLGQRFSVWKSSVKNLLQVIENAKTTQVKPFYFQTR
The following text describes a protein:
Function:
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
MSFQIYRNTSVGESLMETIEQMAQEEKLTEEIALAVLKQFDTSMSKAIKEFVTGKATMKANMKTYHYYENVWTFSLEKVEFKLNQAGNGSMNGAQSLACDTAKVVVVDAKLGEGENPTA
The following text describes a protein:
Function:
May function as an activator of NOX1, a superoxide-producing NADPH oxidase.
Miscellaneous:
MISCELLANEOUS: Although it only shares low sequence similarity with members of the NCF2/NOXA1 family, it may ensure the same function as NCF2/p67-phox.
Sequence:
MLKQTIKKWNQSIERYESGNVGEALTILTSIEQSTSKINYNIGVMYIKSNNFRNAIEYFNRSVEQDKYLASSYYMRAIAHHMNGELNHAIVDYDETISKLRGHEYIDYKQLGLDHKLLLAEVLFNKALALGRAGSSVALQATQCFSQPSDSQEFKNQCKKIQDGSQLNFSTRPIPLSLLFKPPKVSDAPQKQRSATTSSIQSSSPSTPMSSSPPSYILKGPSSPPSSSSPSSSSPSLSSSSSPKLPPTPKPSFGSSPPPSSSSSSSSSSSSSSSSISPLTNKTLPPKPPPLPSKKLPSRPISCVIQDVKITLKVFYKDRRLIQIPVPCNLSTFIQKIELKFEITISDKFSLSFQLDGEENEINSQVQLDKMICMEINEINVKDIIPSPSPSPSPSPDKTNNSTSSYSSSSSSSSSSSSSSSSSSYDNKPKSSFIPKTTTRPILPPTTTTTTSTSNNFNRNATLPKKFGSTPSSPSFSSPSSSSSGGGGGPPIPTRGSPSISLLKQQNQTQSINIPPKVPTSSRPKMTQSHSPPSSSPLSSYSTSFQSVSSPSLSSSYNGSTSSYGGFSSSRPPPTPYPYQVLYTDSNEKYYLNTETNETFWELP
The following text describes a protein:
Function:
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Involved in pollen development, by being required for tapetum differentiation and male fertility. In addition to the sporophytic effect, it also exerts a gametophytic effect on pollen performance.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Mitochondrion. Note=According to PubMed:12897259 it is mitochondrial. However, no clear transit peptide is predicted by sequence analysis tools.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MVLPELLVILAEWVLYRLLAKSCYRAARKLRGYGFQLKNLLSLSKTQSLHNNSQHHLHNHHQQNHPNQTLQDSLDPLFPSLTKYQELLLDKNRACSVSSDHYRDTFFCDIDGVLLRQHSSKHFHTFFPYFMLVAFEGGSIIRAILLLLSCSFLWTLQQETKLRVLSFITFSGLRVKDMDNVSRSVLPKFFLENLNIQVYDIWARTEYSKVVFTSLPQVLVERFLREHLNADDVIGTKLQEIKVMGRKFYTGLASGSGFVLKHKSAEDYFFDSKKKPALGIGSSSSPQDHIFISICKEAYFWNEEESMSKNNALPRERYPKPLIFHDGRLAFLPTPLATLAMFIWLPIGFLLAVFRISVGVFLPYHVANFLASMSGVRITFKTHNLNNGRPEKGNSGVLYVCNHRTLLDPVFLTTSLGKPLTAVTYSLSKFSEFIAPLKTVSLKRDRKKDGEAMQRLLSKGDLVVCPEGTTCREPYLLRFSPLFAELTEDIVPVAVDARVSMFYGTTASGLKCLDPIFFLMNPRPVYCLEILKKLPKEMTCAGGKSSFEVANFIQGELARVLGFECTNLTRRDKYLVLAGNEGIVR
The following text describes a protein:
Function:
Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development.
Subcellular Localization:
Nucleus.
Sequence:
MPSDTPPPSATSVSHPSPASSHHDPNDPNAPPRDPVDRSGTGTPGPSDHPTGGHLGHHQPPSSSSSSSSSSSSSSTSSSLSSLSLKRSLEEPLTTAKPSPPCSPLTMDHHHQHKAARQSRAASPAGRSTQQQASPSAPGTGGSSSGGGGGGQQFCLRWNNYQTNLTSVFDQLLQSESFVDVTLACDGQSMKAHKMVLSACSPYFQTLFFDNPCQHPIVIMRDVSWAELKAIVEFMYKGEINVSQDQIGPLLKVAEMLKIRGLADVSGDAGEPTGSRAEREAAGSRGPEELDREEHGKLLNPLAIVGSSLLANGAASAAMAGGNGSNSTATSGSAAVQAAAAAAAAKKQRAGRDRDTTKEHRMDARLSEFARDLSRADPHISSRDISSVAAAAAAAAAAAAGLAVGEWPLGAAGLEAAAAAAVQASTPKSARKRRWPSGERSSIGSPADSTPDQLEVPSPIPPTPSSLAQSSGGGGGGGGGGGGGTGSGGGGGGSSNPLASFPLPPALDTAAMAMSSLSSSIANHPDDMEIKPGIAEMIREEERSMWQKCWNSQNLIHHLRFRERGPLKSWRPETMAEAIFSVLKEGLSLSQAARKYDIPYPTFVLYANRVHNMLGPSIDGGTDLRPKGRGRPQRILLGIWPDDHIKGVIKSVVFRDAKDMKEEPMMYGRHSPFPFQDNPLSYGPTAPNGQLPSVATGTNVPDGMSQDALTAATVAAVRQQMCNMVAAAQHHPDAANLVAAAGFNLPSHCGTPPNLSMHPAAAAAAAAAAAASNASAAGGPSGGGGGGGSSGAIPLPKMGSPAVPSTGHGNNNGGSGAGIQMPRLGSPAGSSGLAKEHELQHHGGGGGGGGGLGGGSGGGMSRATPPGARDRAMTARSNLAAGETGRSSSSAGSIHRSSPSSSAGSSLNHQHPAHLSHPHHQQQHHHQHHHQPHHGHAHHLPHHNPLSHLVGSGGASGALSITKLGSPGSAHDLRISNSPDESPLASPIGLAMEPAVNLALGAGGTQPGPEDVRLHVPPPYGSKPPSRGGGAPSTGYTSNSSPPRPEHLFQDQDIAALVATTRAACPPSRVPDYKDTAVRPTASIKVEPLTECRGD
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MMAAELVKQYSNITLGEDNKICDIKQALKALRKKILSLDFDNSMHVHDPQDSFEYLEVLRKIKQLSEKLRTLDPGGEAKQLDELTVYAYEISEMAMARLEEEFIYLLTHFKQPLEQEVLSFRSTEDGSVEDFSSSSFSEEPSDGKATPNDISGGPEYFVPDLIQPGALSAVKSIAKFMFLNGYDKECLQAYINSRQTAIDEYFGSLRLEKLSIEELMNTSWNKLNSLIKRWNRAMRGFIRVYLVSEKRLSNHVFSELTDSTADLCFSEISFNSVVQLLSFYVSVAIGPPKTEKLFRLLDMYEVLDDLLPEVESLFEPKYGDMILNEYHEALLQLGESARKTFAEFKCAIQSYTSSNAVARGEVHPLTKYVMNYIKALTAYSKPLDSLLKDTDRRCLTSDIQLMANTYPNFTATALHLQSVTAVLEANLEAGSRLYRDDRLQNIFMLNNTHYMVQKVKNSDLKSFLGDDWIRIHNRKFQQQAMRYERASWNNVLSYLSDDGLCASGDAASRKTIREKIKNFNLSFEEVYRVQTAWSVPDDQLRDDVRISISLKVIQAYRTFVGRYSGFLDGSRHRDRYVKYRAEDLETLLLDLFEGTQKTLQHSCRV
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Sequence:
MFRFAPRRAVHTVPKLAQLSELHAQGIPKVLSAEGFRRCWTEQQQYLCEKLTLATAGTPLESYLPFHLVLNTAQKTFKSNVFNLASAVHNNHLFVENILPAEGAGAKPSIQLLQRIESQFGFGWEELKEEMVRRAETDVVGQGWLFLVENGHKELQILTLQNHGSPYYFARGQAFDLNSPITTEIAAQLQTMREAVDAGNDEDWTMPLIAVSLWDHAYLRDYGVKGRSAYVRAVLDNLNWTVINKRVYTGP
The following text describes a protein:
Function:
Binds the phosphorylated C-terminal domain (CTD) of the largest subunit of RNA polymerase II and functions as a scaffold for RNA processing machineries. May be involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MGSPVYSQLGHPQADGKLPCRVEGKLSKSFVEEIACGAYHVPVLTSRTEVYTWGKGAKWKIRSCSKKSLRTSMAPNPNKPYRVCDNCCNKLKKAIETDASSEASMSRRGSLNQGSTDVIDKSAKLDTRSRPHLTRFSSMEYFKQVETLSSKQKKKFEFNSSRVSPIPSSTLQLGALNSSKSSNQIFASSKKFFSASVPGSRIVSRATSPTSRRPSPPRSTTPTPTLGGLTSPRIVVDDAKRTNKSLSQEVTKLRAQVETLPRKAQLQEVELERTSKQLKEAISIAGEETAKCKAAKEVIKSLTSQVSYIHSYHSTFKLCQSCAYVGKNIVLLFIISTEKVSITSSDIPNGCIDQVHSQLTFQELESSVSNSQLLSNGSSNSSNRSAIHNRQGYPEATTNNGARTKECDSLNENEWVEQDEPGVYITLTSLPGGVKDLKRVRFREESRDGIEEQGITCLLRADASTDRREFTSPEGRKYYYNRVTRTPKWRMPDEVKLAREKDTISHASDFGSISIVKTSSLGADGSLVSAHGAKSSPIAVSPAANLPTIVASESSSLSGKVSSPMIETVEMNNSSEPASPAVADSEKIGIAVTLGNSIAPPVSETTTAQDAVVYGDGFSSENREEAKSAFKTLLESANIGSDCTWDQAMRAVINDRRYGALKSLCERKQAFNEVSLQKKLEAEERRVKQKKAWEDFRIMLEDCKEMSPSSRWSKAISIFEHNERFKAIERAKDHEHLSEDYVEELEKKVFVLVELASVPRLCFPIPGDRTSIVPLLLTSFVQASSQWWKVQDRLETDERCSRLEKIDHVEIFQEYIRDLESEVEEQRKLRMEELRKAERKNRDEFRKLIEEHVAAGILNAKTNWRDYCIKIKDFAAYLAVSSNTSGSTARETREIGC
The following text describes a protein:
Function:
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity).
Subcellular Localization:
Periplasm.
Sequence:
MNTIKILIGLLGIFLFSLSGIVSAQSDATTQLSQLLSNFRTYQAKFNQITFDGQDRVIQQSHGRVMIMRPGRFRWETDSPTKQIIITNGKTLWVYDVDLSQATQQPLAQKTNINPASLLSGSVKDLKQKFTITISPTPDAATFQLVPNLGKSLNFNWIRLKFSKKQLTEMTVLNNLDERSIFQFSQIKVNAPLSSTLFEFKPSRGIDVVKQ
The following text describes a protein:
Function:
Required for the assembly or recycling of the small Tim proteins in the mitochondrial intermembrane, thereby participating in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Probably acts by facilitating the formation of disulfide bonds in small Tim proteins.
Subcellular Localization:
Mitochondrion intermembrane space. Mitochondrion membrane; Peripheral membrane protein.
Sequence:
MIETAIYGKTVDDQSRCVHWHLPKDVIAIRFKCCDKYYACFECHQELSSHPLEKYDLLDDANKHLIICGVCRHEMTFAEYYDYNSNLICPNCRSPFNPGCKLHYHLYFQNPPPAMC
The following text describes a protein:
Function:
DNA polymerase II participates in chromosomal DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MAPNFSGKQRSFRPAGSQSRNWNSAVTAKANEEVVLENIWNEIQSKNEIDTKMGFDNIEAGPPRIGWLLNVHPTSVPSDDNANGKSAIALYFIQEDGETFRVTVPYRPYLYVSTKEGKEAEVEDYLKKAFPNLIKDCKHVYKDDLKLVNHLVGYQKLFVQLFFDNQMDLFTVRRLVLSASRTNENRREATNTYADIFETKDNKDESTNADAPLDYILDVREYDVPYHSRSLIDLNVRVGQWFNVSFKHGEPSITLDESRIERAEPVIMAFDIETTKSPLKFPDSTFDQVMMISYMIDGQGFLITNREIISEDIQDFEYTPKPEFEGPFVIFNEENEMALLQRFFRHIRSAKPSIIVTYNGDFFDWPFVDARASCHGMDMFQEIGFSKDQEDEYKSTYCAHMDAFRWVKRDSYLPQGSQGLKAVTVAKLGYDPIELDPELMTIYASEKPQVLAQYSVSDAVATYYLYMKYVHPFIFSLCNIIPLNPDEVLRKGTGTLCETLLTVQACTRNIVLPNKHVDPLEKFFDGHLLASETYVGGHVESLESGVFRADIPTDFHLDPNVYQELLDQLDSALHFSITIENKKNMEDISNYDETLRDSPTRKENPRIYHLDVASMYPNIMITNRLQPDSIKDESFCASCDLNVPGKTCDRKMIWAWRGEYYPPKRNEYNMIRNALQSEVFPPKFKNGPPRSFDDLSPPEQAERIQKRLSDYSKKVYHKLYDNTIINKETVICQKENSFYIDTVKSFRDRRYDFKGLQKKWGKILAERQKGGTLSGIEEAKKMIVLYNSLQLAHKVILNSFYGYVMRKGSRWYSIEMAGITCLTGATIIQMARQIVERAGRPLELDTDGIWCILPESFPENFTLKTKTGGKFTVSYPCVMLNHLVHEKFTNHQFSVLKNAETLEYETFSENSIFFEVDGPYRAMVLPASKEEGKNLKKRYAVFNFDGSLAELKGFEIKRRGELKLIKTFQAQIFKVFLQGKTLEECYAEVAKVADNWLEVLFSKGSSVDDDELFDLISENRSMTKTLKEYGNQKSTSITTARRWLKDFGRDSFDIRSILDWDYYLERLGSVVQKLISIPAVLQRIANPVPRIPLPNWLFKRVAEQNSKFQQVKLESFLSKQKVEDKNKPVINDIEDILSPAKAHVSPIAIVKKRKAVHSATEAPLTFKETFVPINEDYRHWLVYAKKKWAFQKQVRDRRRTIIGHSNSISGAFQSSMEELINNTWHILQIRPTDVPGLLLAWIVVNKRLTSVKLKVHRKFYVNFKTNDLPEVEIEGCVIEKSNCILPHGKPTNNLFSLIIPEKIYQSECDCLSLIFSHNSVEVCTKEEYHLSNVPSLNWATCRLNGTVSGAFGEALETGFLTSMLNQSEDDYLADIDVKYVYLFHASFDNKMMVGLFYPHLSSADIIIVDKHTTDHSFPPLKKLYEEALPSYKQSEAPSCIKYGDTIEAGVSFCNSPKQMYKSLTDKLSKFVSSKLGVCTLILETSEAFILKKNLKILDDIPFAVIERHDTANMSFSWKSTYAKMMIRHYLGIGPWITHQRQLAAYASIPFCNFEKDNMQYLLDIEYARRLTEKQIILWWNKNPLPDLGGLEHDDILHLTSPSDNFELNYSGAYANASVDIHISNLAMCSILNSAIVNDAEGVEDFSALDDSYLASDSGNLEARFGASENFGLTYSLPILKDLVKELWLEAGKGDLIADLIIQHLVRWVQQTDAHMYDPVLVTHVRLLMRKTFLQLLAEFRRFGVHVVYANAKRVLISTKKPAIQTAASFANYVLKTIKSLPLFHFVDFTIREYWDYLLWMDPFNYGGKACIPESLAQTNCVLQTTVSWHIKKHLPSSMQNEFQNWIIEFVEEIHKLKMEKNEEQKLRVRVRNNNEDVEEEILGAGLIKRKFLAPLERQISQFQHQYQKSLLNSDVDVDFSIPQLPGTHLSPKNPVLEFAKSICTVFNLAGNLSLEVRALQKSLYSILNVRDFSKDTEFIYPSKRLQLEQVPCKHCGNSQDFDLCLNEELWPERTESGQLQFSTGWHCTICNLEYDRWAFEEMLVEVLQKQLLKFQVQDFHCAKCGNIRTSPFKSLCSCSGAWKMSYPQEKFLDLLSVYRNIAEYYEFTMLKAMVSTIDQSIS
The following text describes a protein:
Function:
Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity).
Sequence:
MSQLHRGMHKKPGMFPPKEVLEEVDAGSGSDTETEETVECTEEEEEQDETDGLGDLGMPPPKKTTKSAASPTVPAPALIPSLSHLIGLEGKQPSRKYAPAEWPQYFKQKISVARDNDTFNVLYTPPDDSEAPVYVFHHGAGSCAESFALLSVRLREMMHEERFQLAATAKIRDENKLPGMIAFDARGHGFTEVESTDYSLEAFTNDFAFIVANVVAEFGLTNNLILVGHSLGGAVVTNACHLKLIQHPVIGLAVLDVVEGTAIESLASMQQILNSRPKSFPTVEKGIEWTVQSHTIRNRESACVSVPPTLISQHDGPGMTWRTDLMLTKPYWKGWFTGLSEKFISCAPAKLLILAGTDRLDKDLMVGQMQGKYQLIVFQESGHFVQEDAPDKTALSLIDFWKRNDKVNKTVPLFGAFRA
The following text describes a protein:
Function:
The dimeric enzyme acts as an E1 ligase for sumo. It mediates ATP-dependent activation of sumo and formation of a thioester with a conserved cysteine residue on sae2 (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTNPENTPMTTTNEGGKGLTEYEAKIYDRSIRLWGVDAQAKLRQSKVLFIGINGLMSEIIKNVVLAGVDSITLVDDHIITTSDLSAHLFINEDSVGKVISTESVFAISELNPLVTIDVYDKEIETMDDQFIKNYTMVVISDKNLNNVSKVNSLCRKNNVSFIFSHSFGLKGLFFSDLNEFKYFTKTTTEPPKTETHISIFKSFKESMGYDWSKTNSRTPLPFFALSTLYQFEEKHNRVPDNISDSDLSELKSIINSSIEKFNLKNTDSNKYFEETKDLLNKMNIEISPVCAIVGGIVGAEIIKIITQNMQVLNNFFFYDGVKGTGLVEQF
The following text describes a protein:
Function:
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII. May function as a tumor suppressor negatively regulating cell proliferation and cell migration.
Subcellular Localization:
Secreted.
Sequence:
MFARMSDLHVLLLMALVGKTAYGFSLMSLLESLDPDWTPDQYDYSYEDYNEEENTSSTLTHAENPDWYYTDDQTDPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPCGRGQCLITQSPPHYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPDQFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTVSMPQGHFCGGALIHPCWVLTAAHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTEAGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVYTQVTKFLNWIKATIKSESGF
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
MSGFGTNSAMGSSSLPSRVVYNTGNDLPVEYIYDQGLSYPATNGYAYYGGFEPPVGWSENTNYWGVDGQYLQLTNDNLPYVYCTPGYEFSYSSQDQYTSYMPGMFMGVDGSVVGSQQYFTNPYQPPGSPSGYFPVYLQPTTDLSSAVSLEPPVFSTGTSVASWPANTSIKDTHQMSGNTMASRTVPSASPAIGSSHRAYQNQSTNKPSDLPGANVARHDKPSTSHLTVLVDTDKKFQAASGMGSSGDNGQITDRAEVAPVAAMVGEGAQSKAVSSSAVKNIVIHPDQYNKADFPCDHPDAKFFVIKSYSEDDVHKSIKYNVWSSTPNGNRRLDAAYSEAKGSQRKCPIFLFFSVNTSGQFCGVAEMVGPVDFHKDMDFWQQDKWSGSFPLKWHLVKDVPNSTFRHIILENNENKPVTNSRDTQEIPYKSGINMLKLFKSSPMTTSILDDFPFYEGRQKAMLEQKRRSLGRSFGGLTYVPALVAKRSVVVEGEPSEVGEGISSKDPHPGKTGQDSGACEQPDKTSQTKDGVVTQVLKKDAVSPVEQPEHVKTERHSLDDIHQQNEGCSVSVSPENAGREHAGLSELVKSNGKVYSDRESQPVISSTEPNSSGRKGLSQELGGHDPSDRTKGGASGIMKDVKATLLKKLEGLSTSHTDGQAKGIVNEAPAGVVKVGSVHIKLNVAGGSSSEIIGDGSLELKGAEHIEQGISTKLS
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
Subcellular Localization:
Chromosome. Cytoplasm.
Sequence:
MGRASIGPKTPVHLTSLNDDALEKKRNKERLRKQQHLRRTSAINSITPRTSLTGRESIGSGSPGLNSPFGTPQKKAPLLANFEEWMKLATDNKINSTNTWNFALIDYFHDMSLLKDGDNINFQKASCTLDGCVKIYTSRVDSVATETGKLLSGLANNAQWKEIEDEHAMENDGEDKDELAGAKEKRERKRAHRAEQTLAKSFEALQAKRLDLEYTFDPLFKKMCADFDEGGAKGLLMNHLSVNLHGRIVFDSTDDMVLDEHDDDKTGSNEDKDGAMDEDKEVEEDVKEEEEEEEFNPIMMTDLKNIYFQRLDGLSVCPSLQGFEFGNNTSLNVSLLKSLGEEATSVDGPLVLDNADSQSGPPNLELDVSDDGDDDDAPLDFIGLAQDEEDTTLATAQHAIVDPQHAHPTLVGETTEEQQNQQDYSISSIYSSFNEVYGYFDKSLKHNWAGPELWRIQRLKQKALQDAENRTNSSSALDAASTNDTATSIVSVDKKRRKEVDYTIDFSEPINEESLFAPASANLQLPKNHWRTLNRNLLPDDYHIDSKRLLRLFLKDNALINARSNSSTTSQPEADVDPSTDVPADADNSLVLAHPGLDDGAMSDSDGAADAPLPFVPEGEEDNPFAMDSSKPPSSAGFGESLLLNARLAMPEMLQYAKRATRVDVKVLKERLYECLEIPPSSEEAPEPIVRRFTDVLDKLSAIYEPSAYKDVSTSFAFICVLHLANEHGLKITSSDDLNDLYIERDLSLEPLTT