lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
A probable ATP-dependent DNA helicase implicated in DNA replication, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also plays a role in preserving the stability of 45S rDNA repeats.
Subcellular Localization:
Nucleus.
Domain:
The PIP-box (PCNA interacting peptide) motif mediates the interaction with PCNA and localization to replication foci.
Sequence:
MGFTVVSRSGSPTRRENQKRRVCFRLLLRLLRRGFVVLSAESDPKMPNYSIRGINVEFPFEAYQSQIIYMDRVIESLQNKCHALLESPTGTGKTLCLLCATLAWRKSLGSFSTRKDRKNSAIPWSDSDEPLSQSGGGGGGAFPTIVYASRTHSQLRQVIKELKRSSYRPKMVVLGSREQLCVNEEVNSLRGKALTNACQYLCKKRGKRQCNHFNRLPDYLKHNPHIGDEPVDIEDLVNIGKDSGPCPYYITRELHKDVDIIFAPYNYLISNGYRKFLKVNWTNSVLIFDEAHNLESLCADSASFDLPSVLLSACISEAQECVQLAAARRDSLNDVSINPENFAILKGLLLKLQELISKVPIPKRDEGFTKPGPYIYEMLKSLNITHETAPKLIGTVEEAAVFLEEEKQRTATNAGSKLEIIADMLKLIFRENGSNHADVYRVHVQELEQNSTDVMKGKVSRTLSWWCFSPGITMLDIAQKGVGSIILTSGTLSPMDSLAQELKLDFPIRLENPHVISSNQLWAGVVSTGPSGYVLNSSYRNRDVPEYKQELGNAIVNFSRVVPEGLLIFFPSYYLMDSCITFWKNGCYRNSMTVWERICKLKKPVIEPKDSSLFPAAMRDFSEKLQDRATSGVVFFAVCRGKVSEGLDFADGAGRAVVITGLPYARVTDPRVKLKREFLDEQSQLADVKLPRSTLLSGSMWYSQEAARAVNQAIGRVIRHRHDYGAIIFCDDRFEQPSQQSKISLWIRPNVKCYSRYGEVISDLARFFRTERSNFPARLVTEQENNIVSTLLPVESIEDNPTPAFGNSNLKNVGVAQNELSRLEAFPPANRASPLERDGNNVKRNGLTILKHTGKIPRIVKGDVMQGCSSRKAKLVELSDDEETPVERRCEVVDLESDNCETQTCVTEVLASSTCLNTMGLKKKRKVPESQGSASSSVLTAKGNGGGDKKEASASAFLSQVKEKLNTEEYKKFIGYMQALKKKEIKLANVMQSIVQLFCGSERDHLLMGFKDFVPVKYRPAYEECIKTRKRQSIIFGNSN
The following text describes a protein:
Function:
Cleaves the gamma-glutamyl bond of extracellular glutathione tripeptide (gamma-Glu-Cys-Gly) and certain glutathione conjugates. Hydrolyzes glutathione releasing L-Glu and Cys-Gly dipeptide which is further metabolized to maintain extracellular cysteine levels but also to provide cysteine necessary for intracellular glutathione synthesis. Among glutathione-S-conjugates metabolizes leukotriene C4 (LTC4) and S-geranylgeranyl-glutathione (GGG), but is inactive toward gamma-glutamyl leucine. Converts extracellular LTC4 to LTD4 during acute inflammatory response. Acts as a negative regulator of GGG bioactivity. GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to bone marrow parenchyma (By similarity). The transpeptidation reaction, i.e. the transfer of gamma-glutamyl moiety to an acceptor molecule to yield a new gamma-glutamyl compound requires high concentration of dipeptide acceptor and is considered nonphysiological.
Miscellaneous:
MISCELLANEOUS: A previous study reported that GSH and oxidized glutathione (GSSG) are not substrates for murine GGT5 (By similarity). However, this result contrasts with two studies reported that GSH is indeed a substrate for GGT5.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MARGYGATVSLVLLGLGLALAVIVLAVVLSRHQAPCGPQAFAHAAVAADSKVCSDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAPSLLDQCAQALPLGTGAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSILRPSLQASTLRQLFFNGTEPLRPQDPLPWPALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYSPPPPAGGAILSFILNVLRGFNFSTESMARPEGRVNVYHHLVETLKFAKGQRWRLGDPRSHPKLQNASRDLLGETLAQLIRQQIDGRGDHQLSHYSLAEAWGHGTGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLCERCPRGSGTTPSPVSGDRVGGAPGRCWPPVPGERSPSSMVPSILINKAQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAIAAPILHVNSKGCVEYEPNFSQEVQRGLQDRGQNQTQRPFFLNVVQAVSQEGACVYAVSDLRKSGEAAGY
The following text describes a protein:
Function:
Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
Miscellaneous:
MISCELLANEOUS: Present with 1760 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAPTQLDIKVKALKRLTKEEGYYQQELKDQEAHVAKLKEDKSVDPYDLKKQEEVLDDTKRLLPTLYEKIREFKEDLEQFLKTYQGTEDVSDARSAITSAQELLDSK
The following text describes a protein:
Function:
Together with PhnG, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate.
Miscellaneous:
MISCELLANEOUS: The sequence shown is that of strains K12 and B.
Sequence:
MTLETAFMLPVQDAQHSFRRLLKAMSEPGVIVALHQLKRGWQPLNIATTSVLLTLADNDTPVWLSTPLNNDIVNQSLRFHTNAPLVSQPEQATFAVTDEAISSEQLNALSTGTAVAPEAGATLILQVASLSGGRMLRLTGAGIAEERMIAPQLPECILHELTERPHPFPLGIDLILTCGERLLAIPRTTHVEVC
The following text describes a protein:
Function:
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Subcellular Localization:
Nucleus.
Sequence:
MNTNTQTEQQIIREETRIDKIIKKRKKKMRAQVLLCPTITAYGRLYCAPRRLHRYNSSSSSSQFLNLNLSRFSGALFFHMEQFQSGTGSSGKRGMVENLKRYGVISSKRVAQVMEALDRGLFVPVGSSAYVDTPVPIGYNATISAPHMHATCLQLLEDKLHPGMRALDVGSGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKSVAASFLKKGSLSLHVGDGRKGWQEFAPYDAIHVGAAASEIPQPLLDQLKPGGRMVIPLGTYFQELKVIDKNEDGSIKVHTETSVRYVPLTSRVEQLGGF
The following text describes a protein:
Function:
Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP-bound state of MacB, increases the capacity of MacB to bind macrolides such as erythromycin, and provides a physical link between MacB and TolC. Confers resistance against macrolides (By similarity).
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Sequence:
MMQLSRGQRRWLAAIAVLLIGGFFIARHLMAPVPVNYQTVKVVHRDLQQNVLATGKLDAVRKVDVGAQVSGQLEKLYVEIGDHVKRGQLLAMIDPQQAQNQIKEVEATLQDLNAQRIQAKAELHLATVTLGRQQNLAKLQVVSRQDLDQAVTDLAVKNAKVGTIDAQINKAKASLDTAKINLDYTQISAPMDGDVVQITTLQGQTVIAAQQAPNILTLADMSTMLVQAQVSEADVINLKPGMKASFTVLGDPGKRFSGVLKDILPTPEKVNDAIFYSARFEVPNPDRLLRLQMTAQVSIQLANVDQAVVIPLAALGDELGSNRYQVTVLKEGKEEKREVTIGIRNNVDAQVISGLSVGEDVIVSRGGTGDA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MATNIHMDEVVLDLFVETDKAFQDPINHVQTHSGEKPFMPSNNDQSCAEIHALEKPFMQTTSSQNYTGTHTGEKPFIQNNTGRNYTEIHPLEKPFMQTNSAQNHTETHTGEKPSMPSNNGENYTEIHPLETPFMPSTMDTNAVEDKPFMCGKCNMRFSELADLGVHVQMHSSQKASAQTRTGGQPYSSGEGTTRQFSTQNQVGRSVQTHTGEKPASFEGGSGQFNQQDPKTHMQTLTGEEPCVQTHTGEKPCSYEGDGKQFSQQQHQETHNDMQNIGEGAHMQTHTGEKPGMFNNDKKEESEMGNRRKTRQQSLVCKECGKRFNKSDNLKSHMRTHTGEKPYGCGECGRRFSDGTALRKHKLTHTGEKPYSCEECGKTFGLPATLNRHMLTHTGEKPHSCVECGVQFSRTDALKNHMQTHTGDRPHICKECGQQFRQLGHLRKHKQTHVGKKSQRGNDATPFECDKCGKTFKTPRNLRRHAATHTEEKPYKCDECGKGFRDKQGLGRHVPIHSDEKPFKCDQCSNSYSVERYLKRHMVTHTGEYRYSCEDCGKRFQDREGLARHMRTHTGEKPFQCDECGKRFGQHSSLTLHKRTHLTEKPFPCDKCSKQFSQLAHLKRHLMSIHSGDKPGTSGEGTLEEGELKKGMRFHPCDVCGKTFKKRGVLKSHVRIHTGERPYGCEDCDKRFRDAETLRRHKITHSSVRPFICDQCGKGFNRSQHLKTHMMTHTGERPHVCPECGKGFYDSGGLKDHLMTHTDEKPFMCDECGKQFRQAAALRVHLKTHTGEKPYICSKCGKQCIQLAHLQRHMLIHSDAKPHACGECNKRFRTPTDLKKHGQVHTGARPYTCDECNGQFSQPNALKRHKRTHTGERPYSCRFCSRKFSRQDHHKTHERTHAGPSVLFLE
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
Miscellaneous:
MISCELLANEOUS: Present with 9570 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTMATTAMNVSVPPPDEEEQLLAKFVFGDTTDLQENLAKFNADFIFNEQEMDVEDQEDEGSESDNSEEDEAQNGELDHVNNDQLFFVDDGGNEDSQDKNEDTMDVDDEDDSSSDDYSEDSEEAAWIDSDDEKIKVPILVTNKTKKLRTSYNESKINGVHYINRLRSQFEKIYPRPKWVDDESDSELDDEEDDEEEGSNNVINGDINALTKILSTTYNYKDTLSNSKLLPPKKLDIVRLKDANASHPSHSAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFENFKVAHLQNSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLNHY
The following text describes a protein:
Function:
Binds iron and zinc. May bind nickel.
Subcellular Localization:
Secreted.
Sequence:
MAFSTIVVLFVAAVGFGNKISSADTCPEFGEWKPWTECLWYPMQNIYDKMTASCGLPGHRNLTNILPLPPGFTIPPPCGHCSFKTRCRTRPKKEGCYPFDGEREICHEHGDICTIAKLPGIGCGWTVLQEVVKQCLSRPDIPEYMRAGYKKLFHMLPKGHCIEKDNQCKCCCGDYEPNEDGTECVKQQDHQCAPFNEPGDWSECLWFPLADMFKKVQSHCGVEGKPEGLSPSSLAPAGFQIPEKCGFCSFRLKCQSREKKEGCFPLKVDKKSCGAEDCPTCGDVCTLDKQNNSCAFTKAMGMKFWNSFAHKAKESNLAHWRRDGYADLFKFLPYGHCKEVGDKCKCCCHPYEPNEDGTACVVKQYCKSLEEVGGKKQQKDQPESEKKAENMPETTGNASHHQHRHHHGDSSSESHEQHHHHHHH
The following text describes a protein:
Function:
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MTSLSAASGPEGAPPPNSTPFDAPDARFTLGICVMERKARSAPMMEILGRLPPALFRVEFFGDDTILNEDVENWPRCDALVAFFSQGFPLQKAQDYVALRRPVVVNDLSTQYVLQDRREVYRVLQEHDVPTPRHVFVSRDGYGGQTEPPELVEGDDFIQVDGVRINKPEYDSQVNTVRGGGGSYIYEEFLSTQGTDVKVYTVGPHYAHAEARKSPVLDGRVVRDADGKEVRYPVMLSTEEKQIAFRVCRAFKQTICGFDILRVRDASYVCDVNGWSFVKNSEKYYDDCGILLTQYLEQALASGGATAGEDFGVDSSAFSSVTFRFAPDAPPPSAELSEPPTAHRHAMLRCHTSSIAESEISEADSITDGNEDSLYQEEELRCVLAIIRHGDRTPKQKMKMNVCHPAFLQFYEDRLRESQQENGDGNDTKKKKKMDLKIKAVGNLERLLLVSNDLLHKYETRDPAFMDFLEQREVKFGEDATDRVKGYRTLRDVLQRWQLVGINRKVQLKPKEFVNVPVENASADGEQPTVRRVSKLLLIIKWGGDLTHTGEEQAEHLGQKFRRMMYPGGAGGLNRLHSTYRHDLKIYTSDEGRVQKTAASFAKGLLELEGDIIPILVGLVLKSKDADSMLDQSGSSAQEIIMRVKQRLHKIIHREDHCSQLIASNSRLIRSVALALTKVDQPIRKMGIMHKLLQSLKEQLTRMLQEKAQYRTEIDRWKQKKADAGRLLTPSMGRSASVNELSQPRSRHVHSYAPRKKHSEGSNIPSDAANSSVGLRKLRLQEPLPAEEIKYPEPCGRETLEVMRERWAKLYRDFYVKKRDTYDLSKIPDIHDCIRYDAVHNAHLNLTDVRELLEISSALSHALVPQEYGINVDEKIFIGSAMCRTLLSKINTDLDLARGLGSDVLKDHNTHRLNPSYAKKIKSTHRSVRTRLYFTSESHLHSLLNVLRYGREDCTVKSPVGEEARKWVEDIPELCYMTHFVVRVFERVQYSLTDPQRFRVEISVSPGAVQDPLLSDPEKQIEVAPLKIISREGLTCQELVDYVADCIDYAEQNEIKEMISRTVAVKSDDSPGTTPDESSSNSGDVTPVKRSMYSLSNNSSDSNFSSDN
The following text describes a protein:
Function:
Plays an essential role as an potent mitigator of inflammation. Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways. Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway. In turn, promotes bacterial tolerance. Also inhibits the RIGI-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation (By similarity). Also acts as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue.
Subcellular Localization:
Cytoplasm.
Sequence:
MLPSTARDGLYRLSTYLEELEAGELKKFKLFLGIAEDLSQDKIPWGRMEKAGPLEMAQLMVAHMGTREAWLLALSTFQRIHRKDLWERGQGEDLVRVTPNNGLCLFESQSACPLDVSPNAPRKDLQTTYKDYVRRKFQLMEDRNARLGECVNLSNRYTRLLLVKEHSNPIWTQQKFVDVEWERSRTRRHQTSPIQMETLFEPDEERPEPPHTVVLQGAAGMGKSMLAHKVMLDWADGRLFQGRFDYVFYISCRELNRSHTQCSVQDLISSCWPERGISLEDLMQAPDRLLFIIDGFDKLHPSFHDAQGPWCLCWEEKQPTEVLLGSLIRRLLLPQVSLLITTRPCALEKLHGLLEHPRHVEILGFSEEARKEYFYRYFHNTGQASRVLSFLMDYEPLFTMCFVPMVSWVVCTCLKQQLESGELLRQTPRTTTAVYMFYLLSLMQPKPGTPTFKVPANQRGLVSLAAEGLWNQKILFDEQDLGKHGLDGADVSTFLNVNIFQKGIKCEKFYSFIHLSFQEFFAAMYCALNGREAVRRALAEYGFSERNFLALTVHFLFGLLNEEMRCYLERNLGWSISPQVKEEVLAWIQNKAGSEGSTLQHGSLELLSCLYEVQEEDFIQQALSHFQVVVVRSISTKMEHMVCSFCARYCRSTEVLHLHGSAYSTGMEDDPPEPSGVQTQSTYLQERNMLPDVYSAYLSAAVCTNSNLIELALYRNALGSQGVRLLCQGLRHASCKLQNLRLKRCQISGSACQDLAAAVIANRNLIRLDLSDNSIGVPGLELLCEGLQHPRCRLQMIQLRKCLLEAAAGRSLASVLSNNSYLVELDLTGNPLEDSGLKLLCQGLRHPVCRLRTLWLKICHLGQASCEDLASTLKMNQSLLELDLGLNDLGDSGVLLLCEGLSHPDCKLQTLRLGICRLGSVACVGIASVLQVNTCLQELDLSFNDLGDRGLQLLGEGLRHQTCRLQKLWLDNCGLTSKACEDLSSILGISQTLHELYLTNNALGDTGVCLLCKRLRHPGCKLRVLWLFGMDLNKKTHRRMAALRVTKPYLDIGC
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MYRLLVQKALANNSKRPSAQLFAASRSYSGSARGSNLPPLQEAGFGKVLVVLSPILIGGGVVTYAKYDNEFRKTLITNVPALEPVLKTLLQETNPLDEVSKKMDDISKTIGEYTSTITGFFGGGDEEKKQEKKPDLPPITRAKSVHVPVPSPPLPKPEPINLSDKVPEQPKKKPEAAAPKVTTATATKAAAAATAAAPAKSAPAAPSKPAPLASGGETVPKSISDLEQQVEVAATIAIKEYGHAVDVLKSYTNEVRKVVDESVDKLDSSSWTTLRNRTSARDTALQAAEDAADKARGNIEKLHALLNSREIKCSDELKDKARQNIAAYLDHLKKAKEEVYAARDLASLGEKYWKRVESARNYFVEEMESLFPGINLAERKLNLSKDELDLFILHAYTQVIAHQKELQKLQIEGDQNLRRALEAVRGSDQSEEVKARLEYEIAKEKRQLNLLNQKKLLLTRAELEQQMREQLKRQTEAHVDHLKDALTQKELEMKRKFQRELDEKITTEQASYKLQLAAMLGKLKGIHNALVEIDTEMKEHADAEKSAHQAQALWGACQSLWSSIRSGQPGKSWRDQLRPLKDEIAAVARSAEGDELVTVVLKGLPETAVKRGVYPEDALRERFLKVEEVSRRLALVPAEGARLPMYVLSYLQAALIARPDKPISQDELENKPFDFSKLDTYDILNRARYWLDRGDLVKTVQYVNLLQGAPRKAALDWLNEARLLLETQQAASTLMAHAAASGVRFL
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVTASSSKATGATRLKQANKAVKEPSPDDEFLESDSEVDEFAEGFQPGLAEEYSDDDDDDEGKEDDGEGYGYEESEEEGNAKWEPDNWDGNEDTVSESGSDDDEDAELRNLQNNLNSLPLSTLAKAQKSLSRKSSSSSSNGRSKEEKLALMKSKLAQMQRSKGKAVAVPDTDSHRFGSRAQESDEESDSGPETTSSTKRGSKHAPAALSTKKQVSRKRQVIEVPKPERRDPRFSSVSAGHANADLHSKSYSFLPDLLRQEFSGLKEAVAAAKKAEKNCPWAEKPMRTAERERLEVQMGQVRTKLVRTEKEAMEREVLAKAKKEEREKRTQGKAAWFMKKGEKKDLLLKARFETLEKQGGKTAVKKLVEKKRKKLASKEKKSRPFAKGAEGMGRDTKRRRVA
The following text describes a protein:
Function:
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
METPWSEVNLLLKEHGLPVIVPVQPGHGALSADVTVLDRATAQSLRDSLKSLIQDCDRRQVLIQDLILTNNQLKEKTGRTSTAAAEPSQQLQQLQQQLMESQAMAKTLDRKKTEKERQHRSEVQLLQDNQETLVQRCRELETTVQEQRQRIHRMKAKIKLAVQEEEKRLQTRADEIEDPQQQATSTRGVGGEKEEDVTADILRPADNPDFDATVNYKALLKSYEAQLEEKQKQVEQVTAENRLLQVQINQLQEELNTRPQQKELQYVQHRLTKAEKLLAQNNLSLSNRRRRHKKEDSQSLSTDVSDIPHLPIDVCRQWLEAFASRLKVDDLQEGLRHIRALENTADRVSGLEKFADEVKSIVEDKRAPVLEMRQTGHSHAAWCEKSYRNVLPKLKIWLHNLAGMKHLQASVTQLAGQVVPWDTSFQTVPEGEACPSTADIARNINEMTKKVRQAPHIKGTEEAPSAAVLQTMVGHFQKLFDVPKLSGVYVRMNQVYSRLGEMQNMMNSVREALKLDKSASCQTVVDRVVDLCEAHSSTTAQQLYSLLHTSSLDSVLDRLQQYDKFFPAFNHLVQQLQGILEIDNMEHIVPAVRALKLLS
The following text describes a protein:
Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.
Miscellaneous:
MISCELLANEOUS: Present with 3180 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MINGVYYNEISRDLDISSSTQCLRFLKETVIPSLANNGNNSTSIQYHGISKNDNIKKSVNKLDKQINMADRSLGLQQVVCIFSYGPHIQKMLSILEIFKKGYIKNNKKIYQWNKLTSFDIKREGRNELQEERLKVPILVTLVSDSEIIDLNLHSFTKQ
The following text describes a protein:
Function:
Golgi membrane protein involved in vesicular trafficking and spindle migration.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
Sequence:
MPADYSSTARALALPISPLESPPSSPIQHAERPPWSRRISSGVRRAYNSASPYSSQPTTSFKDQILRKADKLQRKCITAWQNLSTLQKCLAIVAAILNIVLVALFLVYQHQIFASLAPFAERWRDLPGGWMILWAMTFVAAFPPLIGYSSTITIAGFVYGVPKGWAIVATSTVAGSTCSFLASRTILSTYVHRLVGKDKRFEALALTLKHDGIKILCMIRLCPLPYSLSNAAVATFPTVHPLNYALATALVTPKLFIHVFIGSRLGSLAGNEGMDTSTKMINYASIVIGGGLGATVGYIIYQRTMARAKELEIEELEAANGDVAPGRRVAAEYSDANNDDAALMNDDDISLWDNTDEPARYTDFVDEDEANVFASGDLDEEADIGGRGKMTRT
The following text describes a protein:
Function:
Functions as a guanine nucleotide exchange factor (GEF) for Rab small GTPases. Activates specifically RABF1, RABF2A and RABF2B proteins. Required for early stages of embryogenesis, cytokinesis, embryogenesis, and organ development. Is essential for the establishment or maintenance of the polar localization of the auxin efflux carrier PIN1.
Sequence:
MENTDVFLGLHDFLERMRKPSAGDFVKSIKSFIVSFSNNAPDPEKDCAMVQEFFSKMEAAFRAHPLWSGCSEEELDSAGDGLEKYVMTKLFTRVFASNTEEVIADEKLFQKMSLVQQFISPENLDIQPTFQNESSWLLAQKELQKINMYKAPRDKLVCILNCCKVINNLLLNASIASNENAPGADEFLPVLIYVTIKANPPQLHSNLLYIQRYRRESKLVGEAAYFFTNILSAESFISNIDAKSISLDEAEFEKNMESARARISGLDSQTYQTGHGSAPPPRDESTLQKTQSLNPKRENTLFQSKSSDSLSGTNELLNINSETPMKKAESISDLENKGATLLKDTEPSKVFQEYPYIFASAGDLRIGDVEGLLNSYKQLVFKYVCLTKGLGDGTSLAPSSSPLQASSGFNTSKESEDHRRSSSDVQMTKETDRSVDDLIRALHGEGEDVNNLSDVKHEEYGAMLVEGKDEERDSKVQGEVDAKDIELMKQIPKREGDNSSSRPAEDEDVGSKQPVTEASE
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).
Sequence:
MASRGGGQHQRHQQQQQQPGGYGRGGGGGRGRGRDGAPYSGGRGRGQDGSYPGGRGGGYGGGGGGGGPPYYGGGGGGGGGGGGQGRGYYDDGGDGRGYQRGMEGGGGRGGYRGDGDGGYGRGGGGYHGDGERGYGRGGGGGGGGGGGYRGDDEGRSSYGRARGGGGGGGGYHGDGEAGYGRGRGGRDYDGGRGGGGRRGGRGGGGSSYHQQPPPDLPQAPEPRLAAQYAREIDIAALRAQFKGLTTTTPGAASSQFPARPGFGAAGEECLVKVNHFFVGLKNDNFHHYDVAIAPDPVLKGLFRTIISKLVTERRHTDFGGRLPVYDGRANLYTAGELPFRSRELEVELSGSRKFKVAIRHVAPVSLQDLRMVMAGCPAGIPSQALQLLDIVLRDMVLAERNDMGYVAFGRSYFSPGLGSRELDKGIFAWKGFYQSCRVTQQGLSLNIDMSSTAFIEPGRVLNFVEKAIGRRITNAITVGYFLNNYGNELMRTLKGVKVEVTHRGNLRKKYRIAGFTEQSADVQTFTSSDGIKTVKEYFNKKYNLKLAFGYLPCLQVGSKERPNYLPMELCNIVPGQRYKNRLSPTQVSNLINITNDRPCDRESSIRQTVSSNQYNSTERADEFGIEVDSYPTTLKARVLKAPMLKYHDSGRVRVCTPEDGAWNMKDKKVVNGATIKSWACVNLCEGLDNRVVEAFCLQLVRTSKITGLDFANVSLPILKADPHNVKTDLPMRYQEACSWSRDNKIDLLLVVMTDDKNNASLYGDVKRICETEIGVLSQCCRAKQVYKERNVQYCANVALKINAKAGGRNSVFLNVEASLPVVSKSPTIIFGADVTHPGSFDESTPSIASVVASADWPEVTKYNSVVRMQASRKEIIQDLDSIVRELLNAFKRDSKMEPKQLIFYRDGVSEGQFQQVVESEIPEIEKAWKSLYAGKPRITFIVVQKRHHTRLFPNNYNDPRGMDGTGNVRPGTVVDTVICHPREFDFFLCSQAGIKGTSRPSHYHVLRDDNNFTADQLQSVTNNLCYLYTSCTRSVSIPPPVYYAHKLAFRARFYLTQVPVAGGDPGAAKFQWVLPEIKEEVKKSMFFC
The following text describes a protein:
Function:
May be involved in iron transport and iron homeostasis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
LYAAQFLGRWGAGMWDFLVALLLMRVGSNSLLLTAAYGLVQAAATSAFGAAIGSAVDKISHIKASKAKRTELLRSFFALILCDHAQLLRLGIGTRNLSIALSATALSPLLIPGSIPPLGRKLAIAIVHSLGAVGILSGLAVGILLERDWSEAVTLGELPGQSLTRINSAMKRIDLVCKMLAPAFVGIWLSSFSAIPCLIATVAWNGLSLALEYRLLSTVYHRAPALQKLSRSKKCQDKLDPRALSGVTQLVKGACIAMIDGWASYFRQEVVLAAVALAVLHCTVLSFGFVMTAALAWKGVPAHIIGVARGLGAFLGVAATYLYPVIQSKEGTGKAGLWAISTQWLCLMVSVASVWIHKTSVATSLLISGIVASRLGLWMFDLALSSHFCDAQSTVEEQERGRIGGVQSALQSLMTLLSFVITILAPDPKEFGRLVIISYVIVTIAALLFSSYFYR
The following text describes a protein:
Function:
Has E3 ubiquitin-protein ligase activity. Plays a role in male fecundity through the interaction with the E2 ubituitin-protein ligase UBE2J1.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MNPLQTGPWQTSAPSFWLLKFSFIWLVSQNCCTASAVWTAYMNISFHVGNRMLSELGETGVFGRSSILKRVAGVVVPPEGKIQNACDPNTSFILPRNKEPWIALIERGGCAFTQKIKVASENGARGVIIYNFPGTGNQVFPMSHQAFEDIVVVMIGNVKGMEILHLIRKGVHVTVMVEVGRKHVIWLNHYFVSFMIVTTATLAYFTFYHIRRLWVARIEDRRWKRLTRELKKAFGQLQVRILKEGDEEVSPNADSCVICFEAYKPNEIVRILTCKHFFHKNCIDPWILAHGTCPMCKCDILKALGIQMDIEDGSDSLQVLMSNELPGTFSAMEEELNNELPPARTSSKVTHVQEHPTSVNVGSQPPEAEETGHPSFGQHDL
The following text describes a protein:
Function:
Component of the meiotic bouquet that facilitates meiotic nuclear reorganization of the telomeres to the centrosome. Links telomeres to the meiotic centrosome component pcp1. Essential for the formation of normal telomere clusters during meiotic prophase. Required for telomere length regulation and chromosome segregation. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).
Subcellular Localization:
Nucleus, nucleoplasm. Chromosome, telomere. Note=Associates with major heterochromatin, sub-telomeres, rDNA and the mat locus.
Sequence:
MSEINDFTNSIIINESDTKYEVYSEVNSSNRWIAKEDCPSPLEDVWLLKLAGHKRKLEEPLSCMRNEEPASKQREIEKFLRTDLDHSENDFLTQEVDEFPSTQQLFPIPLQNDTAFDSSEESITKSSKSSFSVLDIGLPMSALQRKMMHRLVQYFAFCIDHFCTGPSDSRIQEKIRLFIQSAHNIAKHPSLYDTEVRNPSAAESTNSHVSLDASNFSSYAENSSKFLFLQELFKNLSPSYSKTFFLFISNQFLANTLTQWLKSQNIDAELWAEEDAKTSQHPAIWICVSKKAPSASHFLQSCPDLSATIFYDIEAYMSVTSSLPSIQSLVLRLIHLGSIEHAIKCFQSSYNASFLVNIVGVVATLSSSSEENSEASNLSTLFEKSGNFEEILGSESHSSITEKTRDIAKNVATWLKNGENFSSWPLPPLMDLASLSVAEPRDSQPSVSQVNDTFVKSSDSTFPSSQSMQSPSKLHSLTSNATDLLSSSSLKKNFFSQQEADEVELSNNYDLQGAAVQYLQRRLRMVEDELHEAINSKNVQQSRSEELEQQISKLTDNLQEYRNTVRELKLDLEKSKKKNEDLSKLEVEKVEEIANLKKELTHLAKQQEFGFKYVQEFSNEDLQGKLIEANEKNYKLTQLLKTQKEDADFITNQYQNASTFAAEQSKEVAKLQAECKRLQAINSKVMEEVKVYNDSRVEALLAKVSSLEETLKILEQKSLPKFTPHNQSPRIIDSN
The following text describes a protein:
Function:
Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway.
Miscellaneous:
MISCELLANEOUS: Present with 1340 molecules/cell in log phase SD medium.
Sequence:
MYEMSGIDSLFHDRVVHDYSHTSEQVIVVYISSAAGDNSWLHQWFKPGNLSDEERENILWVRLVNGTKECLLFKSIFPSSSAPSINILQNGLLECSIQGNSLSREQDPWETFINGLQSVFKGQVTKRKLFSKSNEEYQRVKRMIQNDKLERKYVFQNTNDPQRKPQKWKQLTVTDNVSYKSQKGFLAQNYCTLQLKLPNGYTISNTFPPQTKLHKVRMWLDYNCYDDGTPYLFHRNIPRVTLTRNDELKSLQELDLLPRSTLILEPLEANNKTFDYMEQSSLLHKVYSGLTSFWAKEPEVDASSSRLGYQRLGTNVSNSANYSLQKLSSLDMVSDGGGGGGGDSMTPSAYTTPRMYPSNGTSQLRQNVSELNLSSNNSASNTKVRTLGYSNNNGNN
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
Subcellular Localization:
Cytoplasm.
Sequence:
MTTMAKKSLQLGRAVEWPHTPEEAQLDRVPNPQKGTDYLVRFTVPEFTSLCPVTGQPDFAHLMIDYAPGPWLLESKSLKLYIASFRNHGAFHEDCTVMIGKRIASEIKPKWLRIGGYWYPRGGIPIDVFWQTGRVPKGLWVPEQGVAPYRGRG