lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
CQFPFYSVRGRLAQRGQLVTVPPHSPIRQAEALPNEQSTQSSTEQSLGPRAARKPIPHRSQILIRAVPGNARAVRAGLLHIRPERGTSQAREQGPGLHSTRPKVSKKLRGQVGLLFTNRTKEEVNEWFTKYTEMDYARAGNKATFTVSLEPGPLEQFPHSMEPQLRQLGLPTALQRGVVTLLSDHEVCKEGDVLTPEQARVLKLFGYEMAEFKVTIKYMWDAQSGRLQQMGDELPESASESEEESEEEDDG
The following text describes a protein:
Function:
Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Secreted.
Sequence:
MCSRGWDSCLALELLLLPLSLLVTSIQGHLVHMTVVSGSNVTLNISESLPENYKQLTWFYTFDQKIVEWDSRKSKYFESKFKGRVRLDPQSGALYISKVQKEDNSTYIMRVLKKTGNEQEWKIKLQVLDPVPKPVIKIEKIEDMDDNCYLKLSCVIPGESVNYTWYGDKRPFPKELQNSVLETTLMPHNYSRCYTCQVSNSVSSKNGTVCLSPPCTLARSFGVEWIASWLVVTVPTILGLLLT
The following text describes a protein:
Function:
Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
Miscellaneous:
MISCELLANEOUS: Present with 504 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MEHQALRRLVLYCPNFIRRGALRQNMTRVSCRHMSGKGGGRDEKGDCNEEKDSSKDLGRVPSKMKRAYDGETVIKEGDSHAESLAQQGKQPTDLAYNSRSKISGSNLHLLVPRVASTDYISNKEVHTEGLFAGYRPLFLGNSGFPSDARKGKNFHELDDVLPNIQVVDASEKDGKLNVQEIIEDLQRTSLRESIHSMEQLPSSHKRKPVIPWDASISGMVYNDMPFKYVPKNIILKMKPFKLLRIERKSQAKNARKPTMIKLQFHNRRINDTPELVNLYHNKSRLHESLYNTKPLQESGYSSANTSKRQKMLKARSDFEHKQKNYAYKHTFIKNDQELFRNELTKLNKILAREFKKLTKLSIHNEFKREHLPLAVYVSKSKGTKKLFRRSLKMKIMDHIYPVYTTILSTLTNSRDSKKFENKIKAYIEKIIVRLSDEVPSTYFFQDGVDCIIQPSPIHNFKRMHWLRYTKRHNTFWGRTIHKDVQVSFNDKYVVTRSGVRYTRYPTNLNTQLLETAFEEWDYYE
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MSANKLKVSVISPEKILYKGEVDSLIVPGSEGFFGILPNHAPLVATLGIGILEIRKGEKLKVLSVEGGFVEIKDNSISILTDHGALKEDIDLEVEKKNLAEAEKLPPSDSKNLFLQKTKTRILVASR
The following text describes a protein:
Function:
Fructose and glucose phosphorylating enzyme.
Subcellular Localization:
Plastid, chloroplast outer membrane; Single-pass membrane protein.
Sequence:
MRKAAVGAAVVCTAAVCAAAAVLVRQRMKSSSKWGRVMAILKELDDNCGTPLGKLRQVADAMTVEMHAGLASEGASKLKMLISYVDNLPTGDEHGLFYALDLGGTNFRVLRVKLGGKEKRVVEQEFDEVSIPPELMVGTSEQLFDYIAEALAKFVATESEGLHPEPNKQRELGFTFSFPVKQTSIASGTLIRWTKGFNIEDTVGEDVVAELTKAMLRKGVDMRVTALVNDTVGTLAGGRYYKEDVIAAVILGTGTNAAYVERASAIHKWHGPLPKSGEMVINMEWGNFRSSYLPLTEYDIALDEESLNPGEQIFEKMISGMYLGEIVRRVLYRMADEASLFGDTVPSKLKTPFILRTPDMSAMHHDTSPDLKVVASKLKDVLGIPNSSLKVRKIIVDVCDVIASRGACISAAGILGIIKKLGRDTLKQGENQKSVIALDGGLFEHYAKFRECMEDSLKELLGDEVAETIVIEHSNDGSGIGAALLAASHSQYLEEDES
The following text describes a protein:
Function:
Component of the RAVE complex which is required for stable assembly of the vacuolar ATPase complex V-ATPase.
Subcellular Localization:
Cytoplasm. Nucleus. Endomembrane system.
Sequence:
MPLAFTNPGTPLKRTAAYDNVQWNQNRILTFGTRYTVLIIVNNYESYQNIQFGESIGAVALDQRTGFLAIAHGQVLDIYKPADSLKWTHHYNYITQLSEDITQLSWGYNFDLLLCASSYTKLINFSEDKPRLVWSQNRISDSFLSSTISSDACFIASIETKNPLAKVWQRTSPQGTVSSCDDFSYLVHPCRVRFSQWSKHLHPDASGSTPFLSTVGYDNVLRIWQVGSRFGSQLMHLSCFLNLRKYYKSDQPPYCCFIDKDDFTIALAHAISRHSGQVHKDRILNRLLALASGQPHIFLLFTFECLYIFSLVIDQETLSSFELINQVPTNFPKGALQPDGFIPIYRTSKHEFYDYNIILFFQNSAREYMFSLTDFFYSDFELRVSYDFYGHDYPIKSLTRTSNGHGIVSRDVNRICMFQSYISQDGKNQLICRFRLLLGESDFILPLYAGEYAAVLNLNSLKLWHCNEAIPPTLLCTCRQVPTSPIITFFILPVQNNDNSALCALTEGGHAWFWSVSNEAHDGSAVLRFIDRVNFTKNLNIASAVDVMGWSSTLNLSSLSSFDQEVFQSISKDGLLQTWMARVLGDDKAEISEISKVQTSIKSATMIKGSTSKKVAVVSENNRRLSIFDTRSSEFSEKEEFSSVFDDYGPINDLDWTSTPNSHSILAVGFLHDVILLCQNRRSYMNDIPCWSRIRRYNLLEYTNSLISDSSWLDNGTLVTAIGNGLFYFDNSLPEDQSLLFPASLKRSAKNIFDLAYQLNGILPVFHPQLLQQLLLRNQPFLFTNILLRFYLCLKDDVDMHFLLNMDCSEFYCCDEEISKDLLIKSLSQNSAEILNPAELDFEETSVSKHLGLYIDEMIKKLTALLKVKKVKTLTRSSQFLLLNLIEAFNKARALRDSLDLNGKRYCIMLNQYVLSKHQRQLTSLPTREMAWAFHSSNKAVLLDHTKKLHGKPLLWNAVEEYAIPFWLNEQLLKDVFLELSRNHYAEIDDRNPENVSLYHIALHKINVFRDLWRLASWHKESARTVKLLSNDFSKKKWKVVASKNAFALLSKHRYFYASAFFLLADSCYDAAKVCIRNLKSISLAIAMTRVYEGDDGPTLKRLINEYVLPLAVSQNDRWLTNWSFTILKQEKKALQSLVSPIRSLVSDNDFIQLYTSDKNDQEIHENKDSQRNSTNEPVRNKFPSDDPAFILLYECLRSSNVQIDESLEYRFVLHNANVYCQLGCDLIALGLLRNWKFQKNPATAHLETEDYMVTDKQSAVEKTHDSPKLGKTLMGQDIRPTPDDVPEFNESAFSFE
The following text describes a protein:
Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
Sequence:
MTSKEKIPTFNTEEDVESYISFNAQAKIYDDFAIDLQAVESYIQEHVKPKTKVFHSTKERLDFLIKNDYYDEKIINMYSFEQFEEITHKAYSYRFRYANFMGAFKFYNAYALKTFDGKYYLENYEDRVVMNVLMLANGNFNKALKLLKQIILNRFQPATPTFLNAGRKKRGEFVSCYLLRIEDNMESIGRAITTTLQLSKRDGGVALLLSNLREAGAPIKKIENQSSGIIPIMKLLEDSFSYSNQLGQRQGAGAVYLHCHHPDVMQFLDTKRENADEKIRIKSLSLGLVIPDITFQLAKNNEMMALFSPYDIYQEYGKALSDISVTEMYYELLENQRIKKTFISARKFFQTIAELHFESGYPYILFDDTVNRRNAHKNRIVMSNLCSEIVQPSLPSEFYSDLTFKKVGSDISCNLGSLNIARAMESGSELAELIQLAIESLDLVSRISSLETAPSIKKGNSENHALGLGAMNLHGFLATNAIYYDSKEAVDFTNIFFYTVAYHAFSASNKLALELGKFKDFENTKFADGSYFDKYTKVASDFWTCKTEKVQALFDKYQVKIPTQENWKQLVASIQKDGLANSHLMAIAPTGSISYLSSCTPSLQPVVSPVEVRKEGKLGRIYVPAYKLDNDNYQYFKDGAYELGFEPIINIVAAAQQHVDQAISLTLFMTDKATTRDLNKAYIYAFKKGCSSIYYVRVRQDVLKDSEDHTIKIKDCEVCSI
The following text describes a protein:
Function:
Cell autonomous antagonist of the canonical Wnt signaling pathway.
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MGKLQSKHAYKRRENPEGDAFKEVACSEELDRNKQDLCVREAEEDHLSDHYCSLQVTLPPQRLLETSESLHSCPENGRQHPQKDTVRRSGKTDEKECNVSIPDENRQEWMITLYGLDNSGKITKENKLSLMQTICELVEASVKQLVLSNGTTLRVKLSVTPLTSRKTYRKDAGISLNERDQMNETGCSKESQHPQIRVLNSDQLSAPERKQYSVDENTERRNHYLDLAGIENYTSRFEETSAKDPPQDVPSSRVHHRRSQPETCIRVDSSGKSLPFLRSLCSRSKSVGYTAATSKPSKHHGHHPITWCYPSQQQQQHPLLHSSSKRMRARARETASPSRNPQDRDLNCGTALQPTGLIPVPQRHEHHHHHEHHHHHHHHHYHPA
The following text describes a protein:
Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.
Sequence:
QKLFDLVWDVESYPKFLPWCAAARIISENNQEVIAELVIQLKGFSEKYNSRVTSEITGDGIYLINTVAISGPFEYLKSTWQFVPCTAGTELKFFIDFKMKSVILDKLIGTYFTKATEKMIVAFEKRAKEVIK
The following text describes a protein:
Function:
Thiolesterase that catalyzes the hydrolysis of S-D-lactoylglutathione to form glutathione and D-lactic acid. Involved in the metabolism of methylglyoxal, a toxic compound for yeast proliferation, by converting methylglyoxal to lactate via S-D-lactoylglutathione by sequential enzyme reactions catalyzed by glyoxalase I and glyoxalase II.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MKFLLQQIRNMHVKPIKMRWLTGGVNYSYLLSTEDRRNSWLIDPAEPLEVSPKLSAEEKKSIDAIVNTHHHYDHSGGNLALYSILCQENSGHDIKIIGGSKSSPGVTEVPDNLQQYHLGNLRVTCIRTPCHTKDSICYYIKDLETGEQCIFTGDTLFIAGCGRFFEGTGRDMDMALNQIMLRAVGETNWNKVKIYPGHEYTKGNVSFIRAKIYSDIGQNKEFDALEQYCKSNECTTGHFTLRDELGYNPFMRLDDRAVRLAVGDTAGTYPRSVVMQELRKLKNAM
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA.
Subcellular Localization:
Nucleus.
Sequence:
MNGDSYSRDGGRQGGRSNYVSADKTLNTGRTLTGQSSRDDRRGGDRGGDDRRRRRSRSPRHGGGGGGGSRRDYEVDTYSSSRDYREREREDTYARRETRRDDRGAGGERGDRSWGDSYARRDRPGRDRGDRDDDRAPRQDRRDRRDRGDRDGGGYGDDRRRGGRDGGGFGGGRGGPRQPKEESPLPNKAREPTPDLAPFTNILKRERRMTQWDIKPAGYENITAEQAKLSGMFPLPGAPRAAPMDPSKLAAFMSPSAGTASAAALAPGASKQSKRLYVHNLPSGTTSEELLEFFNLQLNGLNVVSGQDPCLSAQIASSKTYAALEFKTPEDATVALAMSGISMRDDGGGPDRSGLSIRRPKDYITPSADENAYPGDEVSSVVKDSPNKLSIVNIPTFIEEEQIRELVETMGKLNAFVLVKDISSEQHRGIAFCEYADNEVVNAVIEGLNDITLGEGNLKVSRATVGMQQNAGLDGGVNAISMLASAEPTSNLEHGRVVCLMNMVTSDELINDEEYEEIKEDIEEECQKYGPIVETKIPRPAGARSSLGVGKIYIKYQDTESAQRAIKALAGRQFSRRTVVATQFSEEGFDVDAW
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAYCLTSCYQDSVTFEDTAVDFTQEEWTLLDPVQRNLYRDVMLENYENVAKVGFQLLKPSVISWLEEEVLRTLQQGVLQDWAIKHQTSVSALQQDFWKIQTSNGIQTDLVTFDSVAVEFTQEEWTLLDPTQRNLYSDVMLENYKNLSSVVYQLFKPSLISWLEEEEELSTLPRVLQEWKMCLKTNGPALWQDNFCLKTLNGIQLARNQNGEELYDCKQCEDVFCKHPCLKTNMSTQNRGNTSECIQYAKDLLSLYNKTSTIRKVSVFSKHGKSFRLILNVQVQRKCTQDKSFEGTDYGKAFIHQSHLEAHRKTQSGEKLNEWKQCGEAFTHSTSHAVNVETHIIKNPYERKECGKDFRYPTHLNNHMQTHIGIKPYKCKHCGKTFTVPSGFLEHVRTHTGEKPYGCKECGKAFGTSAGLIEHIRCHAREKTFKCDHCGKAFISYPSLFGHLRVHNGEKPYEHKEYGKAFGTSSGVIEDRRSNTGQKRFDCDQCGKVFVSFSSLFAHLRTHTGEKPFKCYKCGKPFTSSACLRIHMRTHTEERLYQCKKCGKTFTKCSYLTKHLRTHAGEKPYECMKCGKAFTERSYLTKHLRRHSGEKPYECKKCGKAFTERSDLTKHLRRHTGDKPYEYKDHGKAFVVSSRLVDHLRTHTGYKPYKCNACEKAYSRSCVLTQHLKTHAAEKTSECNACGNSFRNSMCFHDRLKTLTEIKPYKCKDCGKAFTCHSDLTNHVRIHTGEKPYKCKECGKAFRTSSGRIQHLRTHMGEKPFECDQCGKAFASFSARIAHLKTH
The following text describes a protein:
Function:
May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDSQNREIMKHLKAICFLRPTKENVDYMIQELRRPKYTIYFIYFSNVISKSDVKSLAEADEQEVVAEVQEFYGDYIAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLSSEAAKRLAECVKQVITKEYELFEFRRTEVPPLLLILDRCDDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKKPKEQQKLESIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDHSSALQNVKRLLQNPKVTEFDAARLVMLYALHYERHSSNSLPGLMMDLRNKGVSEKYRKLVSAVVEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENLYPYLGPSTLRDRPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNTKSFLEEVLASGLHSRSKESSQVTSRSASRR
The following text describes a protein:
Function:
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Sequence:
MANQEKIEAVALLKGKLETRNNFILACYSGLTVEEITGLRAQLRKEGSEMKVLKNNLFLRALKESGAHKDKNITFGSEYQGPLAAIFAKDNLPAIAKVCKDFAKNNKNLIVKAGYMDGSVLDANGVDAIAGLPSREQLLAQIAGGINGPARTIASGINQIIASLARAIQATAEKNNA
The following text describes a protein:
Function:
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Functions as a transcriptional corepressor by associating with ZHX1 (By similarity). Required for DUX4 silencing in somatic cells (By similarity).
Subcellular Localization:
Nucleus. Note=Accumulates in the major satellite repeats at pericentric heterochromatin.
Domain:
The PWWP domain is essential for targeting to pericentric heterochromatin.
Sequence:
MKGDSRHLNEEEGASGYEECIIVNGNFSDQSSDTKDAPSPPVLEAICTEPVCTPETRGRRSSSRLSKREVSSLLNYTQDMTGDGDRDDEVDDGNGSDILMPKLTRETKDTRTRSESPAVRTRHSNGTSSLERQRASPRITRGRQGRHHVQEYPVEFPATRSRRRRASSSASTPWSSPASVDFMEEVTPKSVSTPSVDLSQDGDQEGMDTTQVDAESRDGDSTEYQDDKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMPGMRWVQWFGDGKFSEISADKLVALGLFSQHFNLATFNKLVSYRKAMYHTLEKARVRAGKTFSSSPGESLEDQLKPMLEWAHGGFKPTGIEGLKPNKKQPVVNKSKVRRSDSRNLEPRRRENKSRRRTTNDSAASESPPPKRLKTNSYGGKDRGEDEESRERMASEVTNNKGNLEDRCLSCGKKNPVSFHPLFEGGLCQSCRDRFLELFYMYDEDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGAGTAEDAKLQEPWSCYMCLPQRCHGVLRRRKDWNMRLQDFFTTDPDLEEFEPPKLYPAIPAAKRRPIRVLSLFDGIATGYLVLKELGIKVEKYIASEVCAESIAVGTVKHEGQIKYVNDVRKITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYTRPKEGDNRPFFWMFENVVAMKVNDKKDISRFLACNPVMIDAIKVSAAHRARYFWGNLPGMNRPVMASKNDKLELQDCLEFSRTAKLKKVQTITTKSNSIRQGKNQLFPVVMNGKDDVLWCTELERIFGFPAHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
The following text describes a protein:
Function:
Multidrug efflux transporter. Contributes to resistance to several antibiotics, including fusidic acid, novobiocin, streptomycin and actinomycin, possibly by pumping these structurally unrelated antibiotics out of cells.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDLGGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMTELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWIVDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLALSFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGFFMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQIITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEELGVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKGMIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAVFTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH
The following text describes a protein:
Function:
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity).
Miscellaneous:
MISCELLANEOUS: The propeptide plays a role in directing the deposition of this enzyme to elastic fibers, via interaction with tropoelastin.
Subcellular Localization:
Secreted. Secreted, extracellular space.
Sequence:
MRFAWTALLGSLQLCALVRCAPPAASHRQPPREQAAAPGAWRQKIQWENNGQVFSLLSLGSQYQPQRRRDPGATAPGAANATAPQMRTPILLLRNNRTAAARVRTAGPSAAAAGRPRPAARHWFQAGYSTSGAHDAGTSRADNQTAPGEVPTLSNLRPPNRVEVDGMVGDDPYNPYKYTDDNPYYNYYDTYERPRPGSRYRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMAMYNLRCAAEENCLASSAYRXDVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYNADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYSNNVVRCEIRYTGHHAYASGCTISPY
The following text describes a protein:
Function:
Sigma-2 receptor which contributes to ameliorate dysfunctional cellular processes and slow degenerative progression by regulating cell functions including cholesterol biosynthesis/trafficking, membrane trafficking, autophagy, lipid membrane-bound protein trafficking, and receptor stabilization at the cell surface. Forms a ternary complex with PGRMC1 receptor and low density lipoprotein receptor/LDLR at the plasma membrane, which increases LDLR-mediated LDL cholesterol internalization. Decreases lysosomal sterol transporter NPC1 availability to the cell, probably through NPC1-binding, hence controlling lipid transport, including cholesterol and LBPA, outside of late endosome/lysosome. Binds regio- and stereoselective ligand 20(S)-hydroxycholesterol (20(S)-OHC), thereby linking OHC binding to cholesterol homeostasis. Also able to bind cholesterol. Binds histatin 1 (Hst 1)/HN1 salivary peptide at the ER membrane, which is critical for increasing mitochondria-ER contacts and stimulating Hst1 wound healing properties. May alter the activity of some cytochrome P450 proteins. Although shows homologies with sterol isomerases (EXPERA domain), not able to catalyze sterol isomerization. However, may act as sensors of these molecules. Acts as a quality control factor in the ER, promoting the proteolytic degradation of nonproductive and extramitochondrial precursor proteins in the ER membrane thus removing them from the ER surface.
Subcellular Localization:
Rough endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MAVCSRLLEWIFFFYFFSHIPITLLVDLQAVLPPSLYPRELLDLMKWYTVTFKDHLMANPPAWFKSFVYCEAVLQLPFFPVAAYAFFKGGCKWIRIPAIVYSAHVATTVIPIIAHVIFGDFPKSDAIAPLTQKDRLTLVAIYAPYLVVPVLLLLTMLFSPRYRQEEKRKRK
The following text describes a protein:
Function:
Transporter required for vacuolar uptake of histidine, arginine and lysine and to a lesser extent tyrosine.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MSISNWITTAYLITSTSFQPLYGSFSDALGRRNCLFFANGAFTIGCLACGFSKNIYMLSFMRALTGIGGGGLITLSTIVNSDVIPSSKRGIFQAFQNLLLGFGAICGASFGGTIASSIGWRWCFLIQVPISVISSILMNYYVPNQKEYNRQNSSIFQNPGKILRDIDVMGSILIITGLTLQLLYLSLGCSTSKLSWTSPSVLLLLVGSVIILLLFILHERKTSARAIIPMELVNSSYSVVVLSISILVGFASYAYLFTLPLFFQIVLGDSTAKAGLRLTIPSLFTPVGSLITGFSMSKYNCLRLLLYIGISLMFLGNFLFLFIEKTSPNWLIGLFLIPANLGQGITFPTTLFTFIFMFSKSDQATATSTLYLFRSIGSVWGVAISAGVIQLSFAGLLRSNLKGLLDENKIKKLIVQLSANSSYIGSLHGEVKNTVIKSFDEATKRAHLMSTLLSSLALILCILKDNLAKPKTRR
The following text describes a protein:
Function:
Component of the viral envelope that plays a central role in virus morphogenesis and assembly. It is sufficient to form virus-like particles. Seems to be important for creating the membrane curvature needed to acquire the rounded, stable and infectious particle phenotype. Acts as a viroporin, inducing the formation of hydrophilic pores in cellular membranes. Also induces apoptosis; Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subcellular Localization:
Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal.
Sequence:
MFNLFLTDTVWYVGQIIFIFAVCLMVTIIVVAFLASIKLCIQLCGLCNTLVLSPSIYLYDRSKQLYKYYNEEMRLPLLEVDDI
The following text describes a protein:
Function:
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the chloroplast. Required for the accumulation of TOC34, an essential component of the outer chloroplast membrane translocon (TOC) complex. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to chloroplast, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MALASGNRLGSARGQTCADASGRVAPRLLSRACSGSPLALGVLACLGAASSVKPHPRLPATTSAASAPLPARGPAPCAAVPTVVTPDNATGVFEELAAGQQRKYIMISGKGGVGKTSLSASLAVKLAAAGHTTLVVSTDPAHSLSDSLAQDVSGGRPVLLQGTDLPLWGLEIDPEEAKREFFEGSGAGQDGEAGGPSAASQVSDFMNRMGMGFVIDQLKELKLGELLNTPPPGLDEAVAIAKVVQFVQAAEYARFSRIVFDTAPTGHTLRLLALPDFVDASLAKVIRLRKKLNGATSVVRGLFGAGESQDEAVEKLELLQQRVRMVKALFRDKTQTEFIIATIPTYLGVNESSRLLQALRAEQIPCKRIIVNQIVGPQQGDAYLRMKMKDQIAALEMVANDPGLRPLRKVIAPMVDVEVRGVPALSYFGNVVWKDVYDQMNQGADRKFFLLGGKGGVGKTSCSSSLAVHFANDGLPTLVVSTDPAHSLSDAFDQDLSGGSPVKITSPLGDELPLWGLQLDPEQAKAELRAVLADDGGKKLNETLDGLGLGVISDQLKDLQLGELLDTPPPGVDEAIAIAKVVQFLKAPEYSHFKRIVFDTAPTGHTLRLLSLPDFLDASIGKLVRLRQKLSAATSAVKNLFSGGQPGEEDVAVKRLEALQASMEDAKAMFRNQQTTEFIIVTIPTVMATAESCRLASALQHEGIPLKTIIVNQVVQANATDKFLTARRADQARALHHLEEDTGPDGLASLQLIKAPLCDLEVRGVPALSYFGNVVWK
The following text describes a protein:
Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Subcellular Localization:
Nucleus.
Sequence:
MGTPPGLQTDCEALLSRFQETDSVRFEDFTELWRNMKFGTIFCGRMRNLEKNMFTKEALALAWRYFLPPYTFQIRVGALYLLYGLYNTQLCQPKQKIRVALKDWDEVLKFQQDLVNAQHFDAAYIFRKLRLDRAFHFTAMPKLLSYRMKKKIHRAEVTEEFKDPSDRVMKLITSDVLEEMLNVHDHYQNMKHVISVDKSKPDKALSLIKDDFFDNIKNIVLEHQQWHKDRKNPSLKSKTNDGEEKMEGNSQETERCERAESLAKIKSKAFSVVIQASKSRRHRQVKLDSSDSDSASGQGQVKATRKKEKKERLKPAGRKMSLRNKGNVQNIHKEDKPLSLSMPVITEEEENESLSGTEFTASKKRRKH
The following text describes a protein:
Function:
Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (By similarity). Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis (By similarity). Regulation of lumenal pH stability is required for autophagosome-lysosome fusion (By similarity). Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes (By similarity). Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (By similarity). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (By similarity). The lysoK(GF) complex is required to protect neurons against stress-induced damage (Probable).
Subcellular Localization:
Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Domain:
Composed of two modules of six transmembranes, forming a homodimer with a tetrameric architecture. The six transmembrane regions of each module are tightly packed within each subunit without undergoing domain swapping. Forms a central ion-conduction pore lined by the side chains of the pore-lining helices. Conserved isoleucine residues (Ile-43 in the first module and Ile-268 in the second module) in the center of the pore serve as the gate in the closed conformation. In the widened channel in the open conformation, the same residues establish a constriction essential for potassium selectivity.
Sequence:
MSRLQVQEQAVDSEGDSSLYRRDEEGTQSSHRMLGFSDALLSIIATVMILPVTHTEISPEQQFDKSIQKLLATRIAVYLMTFLIVTVAWAAHTRLFQVVGKIDDTLALLNLACMMTITLLPYTFSLMVTFPDVPLGIFLFCMCVIAIGSVQAMIVGYAFHFPHLLNPQIQCSTHRALSRRHILHLVLRGPALCFVAAVFSLFFFPLSYLLMVTVIFLPHISKATTWCKDKFMGHRESPAHNVEPFSIDLHAPLSKERVEAFSDGVYAIVATLLILDICEDNVPDPKDVQQKFSGSLVAALGAYGPQFLAYFGSFATVGLLWFAHHSLFLHVRKATQTMGLFNILSLAFVGGLPLAYQQTSAFARQPRDELERVRVSCAIIFFASIFQFAIWTTALLHQRETLQPAVQFGGQEHAFMFAKLALYPCASLLAFAATCLLSRFSTAIFHLMQIAVPFAFLLLRLLVRLALAGLQVLWDLWPERPQQDQGEPETQSQLLPASC
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MAETKRLERLKAMRSLLKSEMEKTKTSSLVLEKTGSKLEELNTKLLSLEADVKVERWRSSPFSDHIRYTIAPVSAALRVFATVQELERDLMSCNEVLGYVSDVKCLGEALKLLTSSCVLALNWLEDTTKFLSENGMPEDHPCGLRFKTSLELLRELQMTEARAYLRGGSLYTALENLEIELEMILEEEEVLSEYNLRDMKAIIKRLDAHTMLTNCVHVYIKNRTRVIQKRFEIDYLERKITETAIEGYIDQWRVDMELAVKEVYEFESNLCYEVFKDVGEEEYVPLHCFGAIASKSGIIPLLRFGSRISKWKKSPPKLLRLLECFSTMDNVRTEFNRLFIGEECSEIRRETRELISNLVKGVCEIFWELPCQVELQRPNCPPLDGGVPKLVSVVTEYCNKLLGDKNKPVLSKILEIDLGWKNEKYQEEILTGHMYNILREIALNLDAWSSSNKETALSYIFMMNNHSHFCGLRETPLGLMMGESWLNAHEQYRDYYAALYVKESWGKLLSLLNNKAQTVKTTLQAFAKGFDEMYTKQSRWVVEDEKVRWKICEAMVRTVVPKYKSYLQSYIMLLVEEDDYKSHGKDMNYYTPKGLEMKMRTMFQSKEEREFSHFDGYKD
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MHCFLGNCYCPLVYSVSFLSSPSLGGPCTCSGKCKCKECKCTSCEKGGCCTCCPSECPKCSKQCVDKGTDKCSCNH