lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes metal ion-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane and participates in the redistribution of phospholipids between membrane leaflets. Metal ions bind to the calcium-binding site and induce conformation change in the protein. Has a greater affi nity for Ca(2+) than Mg(2+) and Zn(2+).
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor; Cytoplasmic side. Nucleus. Note=Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus.
Domain:
The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
Sequence:
MSGLVPTAPEQPTEEMENQIKSPTAVPDAPPDYNSHFAPGPAGPVASPSAGLPMGYYIPQQPGAIPLYHPTGGTHPIQYQPGKYPVTNQPAPIMWMAGPAPVPNCPPGLEYLAQLDNIHVLQHVEPLELMTRFETNNRYDIKNNIDQMVYIVTEDTDDFTRNAYRNLRPFVLRVTDCLGREIMTMQRPFRCTCCCFCCPCARQELEVQCPPGVTIGFVAEHWNLCRASYSIQNEKKESMMRVRGPCATYGCGSDSVFEINSLDGVSNIGSIIRKWNGFLSTMVNADHFEIRFPLALDVKMKAMIFGSCFLIDFMYFERPPPRRMSR
The following text describes a protein:
Function:
Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology. Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant. By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis. May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin (By similarity).
Miscellaneous:
MISCELLANEOUS: Monogastric animals cannot hydrolyze dietary inositol hexakisphosphate (InsP6) which makes up the bulk of organic phosphates in soybean, grains and other plant seeds which are the primary source of animal feed. The high activity of the chicken protein toward InsP6 offers a genetic strategy for improving InsP6 digestion in poultry and reducing the pollution that results from high phosphate content in manure.
Subcellular Localization:
Endoplasmic reticulum lumen. Secreted. Cell membrane. Note=Also associated with the plasma membrane in erythrocytes.
Sequence:
MAPRRAACLLPLLVAVASAGLGGYFGTKSRYEEVNPHLAEDPLSLGPHAAASRLPAACAPLQLRAVLRHGTRYPTAGQIRRLAELHGRLRRAAAPSCPAAAALAAWPMWYEESLDRLAPRGRRDMEHLARRLAARFPALFAARRRLALASSSKHRCLQSGAAFRRGLGPSLSLGADETEIEVNDALMRFFDHCDKFVAFVEDNDTAMYQVNAFKEGPEMRKVLEKVASALCLPASELNADLVQVAFLTCSYELAIKNVTSPWCSLFSEEDAKVLEYLNDLKQYWKRGYGYDINSRSSCILFQDIFQQLDKAVDESRSSKPISSPLIVQVGHAETLQPLLALMGYFKDAEPLQANNYIRQAHRKFRSGRIVPYAANLVFVLYHCEQKTSKEEYQVQMLLNEKPMLFHHSNETISTYADLKSYYKDILQNCHFEEVCELPKVNGTVADEL
The following text describes a protein:
Function:
Directs RNA polymerase II nuclear import.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAIKCYDGDEELFKIENKFKFAGTVHQANDSLIHQTVKTAIRQYKLENERKRHCDVADDHKPSKKRRISLHKGYQIIEKKTAETFDSFDFSPFQNVQHVEAYKQCDDAEYLAEEEEEEEEEEAYEEDDNEDCENNWRNDYPDESSWFYNADPNFSCYDCVQPKSKQAIEQHLLSNISIHTTELQAINFALEFIKSKINKSLLVITDSLSSALAITQVMIGHTNITYNCLLSKTDPPVCKYC
The following text describes a protein:
Function:
Transcription factor (By similarity). Plays a role in embryogenesis and later development, perhaps acting redundantly with forkhead protein fkh-2.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MLPLSISTSPDPASQFPTVPDLPTLTPTPSPTSGTAKMNEFTISNLCPEASDRLSLEVSPSSTGLLEPKSSTVSPAPSCTGYPIFDLTGISKQSSSGVSSTRTSSLEPKSSAVSPAPSSPEASNPNKRPAYSYNALIAMAIQNSPFKALRLSEIYAYISNNFPYYKMENGGWQNSIRHNLSLREEFYKVQTTDGKGSFWAMNTQLGSDVYIGKDCGSLRRKKNGKPRKYSKRSNTVSNPNPIPQIPSFTPSPLLATPFPLFLYISQAYAQNPNLLPMMLQNFQHFNFQNIPALSFPFPFSNSNGNPNSRN
The following text describes a protein:
Function:
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAADWAVVGKQKKSRKQTGGDKKTQSQNGSESAPKIEDMVDMDEICSLYSDVKDDVFAKFNGLKDANAGAKADPKKTLAPVNGKRTATPVRDQALQQGGGSNKNNQQREPESGTAPAKQTYRSLDAALRAISAPDLHSQLAAVNVSFKDNHLMLLKALTGILNDKLRVDDAAADPLYSSKPTTYPYKTMPTALRTVIDECIGKANEENVKYFYDLTLSNLASDLNKGLPHLGHKVILQAIAMHYPSACVNNLARNAILRNSYQNRHNIGLSLLWALGQGGYNDLDVGLKVWQDIMVPVMELKNYNRFTSDYVVRILRLHRAHRLTLGGSEFLTILSSLTTQPKACRELDEAAQLLVERYVFSAPKASATFTMLFKNVSFITRPEMIYYGLALCLLEDPESAAVWLGLYRSNVETSLAILSYLNTSSQKNCSKLLGEDHFIRFLSDVEKLNEELQQSKKKIEGLESVTSILKEVQGKSKKKQSSKVNSKSSSSVTSVLCSFLLATFLLFGVTGALIGYDTYRAGGKFEASFTGQTLKQAGLLPAVQDAWTCTMKYSARGYKWAETNVPVYYQATSKALGPYVEFSIDFGKVLWNGTKKGFANMKLLAEQKLPVVADFIEQYAPGLPKKIGDASCAFCDTVSTFASNAYKHTFEFFKTQVFVGKLSMESLGKAFNSTQQAAAQYYSWFNDQVDFYAKLK
The following text describes a protein:
Function:
Cytokinin receptor related to bacterial two-component regulators. Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MGDEYLAEPEDEVAISMWPENIGDKHQKQFKMEKLGKDQDALEDANFQQKPSSVDLNRLMELANSEKGVSQMQYFVKHWEYKRANTARLLKEQIGLLCQQRKEIEQRKQQILEEQQFQDESYYAVKWQVPILDEVYKDEWKRPSKKNDDLSHNQELKIDAEYDSISYWKERAMQLEKTLEASLQRERSLEEKLEENIKNLQSHTPVEEFSGMLKRADYFLHLVLQSAPIVIAHQDADLRYRFIFNHFPTLADEDVIGKTDYEILSGEGIEEMNNVKKEVMASGKATKREFVFNTPLFGAKTFVTYIEPVFSKSGETIGVNYVAMDITDQVTRREKMADIRVREAVQKAKETELSKSLHITEETMRAKQMLATMSHEIRSPLSGVLSMAEILATTKLDKEQYQLLEVMLSSGDLVLQLINDILDLSKVESGAMKLEATTFRPREVVKHVLQTAAASLKKELILEGCIGDNVPLEVTGDVLRIRQILTNLISNAVKFTHEGKVGINLHVLDKQLPGCRIEGGQLHSKAHSAPAAAAEHFSASPRKCDNDTLGCSNHEDACQTGIPSNDNFGEHHEGDEVVWLRCDVYDTGIGIPEKSLPLLFKRYMQASDDHARKYGGTGLGLAICKQLVELMGGTLTVVSKENEGSTFSFVLPCKIPVKEDHSDDPDDMPSSGGDFTTSDIEGSFIFKPQARPYLLTSGVSVMNNTKLIGGNQFYDPPNILEDRKPFSNGFVLAEDHSTNSASTAHQSNGPSVSRTNKEQHDNAMVIELNRQAERVSSSRGDTTSVSGLIHDERGPCRVHEEKSLHKKSKCSPSSNKAKILLVEDNKVNIMVAKSMLEQLGHGIDIVNNGLEAIRAIQKRQYDIILMDVHMPEMDGLQATKFIRSFENTGCWDTSVKPEHDQIIAGSDNLSDCAHMKKQGKRVPIIAMTANSFSESAEECLAAGMDSYISKPVNFQNIKECLQQYLPPQ
The following text describes a protein:
Function:
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. Likely functions in some aspects of cellular RNA processing. Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury.
Sequence:
ANMAATTFAIDGSIMEGGGQILRVSAALSCVQGASLSISKIRAGRSTPGLRPQHLSGLELVRDLCGGHLEGADVGSTEVALSSGKIKGGSHVADTKTAGSVGLLLQVSLPCVLFADAPSELCLKGGTNAEMAPQIDYTMKVFRPMVEKFGVKFDCELKMRGYYPRGGGEVIVKTNPVKELSPASLIERGSITKIYGRAFVAGVLPHKLAKDMATAAVRQIRKEIKDLYVNIQAMQEKKEEAFGNGNGIIIFAESSTGCVFAGSALGKKGVYADKVGIEAAEMLLRNVRHNGCVDEFLQDQLIVFMALANGTSRVRTGPVTLHTRTAIHVAEQLTKAKFTITKAEDQNSTNETHIIECQGVGMTNPHF
The following text describes a protein:
Function:
Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs. Required for the correct positioning of the substrate tRNA for methylation. Required to suppress amino acid starvation-induced autophagy. Enhances the STK11/LKB1-induced cell growth suppression activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MEPPVGKAQSLLLLAPVTALQCVGDRVLAGEGPNLLIYCLESGEQLVVTKCVPSVLSHYYIHGIRELQSPSSTKASETTVAVFGSKGLRVLTLSWGEKAESLTWMSQLCELHDWIWDLHWVQGPGKATLALALALGHNSVVLYDHIHQQILQEVHCEETCIIYSACLAGKDWQELVLVAGTVFNQLVIWHPADFTGEERRVKVERRISGHNGVIFSICYLESKGLLASASDDRSIRVWRVGDLRAPLSLVQCILVCYGHQSRVWAVQLLDNYIISIGEDSACIVWNYSGEIVQTFKGHKGRSIRAVTVHQTQAWMVTGGADSGIRLWPLRGNRLLGNSLLPLRFSSFTKKGSPKALTLVSSSWLLVMTDIGAVYLYDLTIKQWKFILDDINYQSYNLLDAVQLPGGSVICALGNLEGRIKIFPLHYPQEAKELKLYKGKVHGLSWVTRQPQDPLRHDSCCALFLSGPDGVLSWLDVSFCPLGKVDKVVERRRYVLPLCKQRWHTCLTFLPQGDFFVCGDRRGSLLLFPCGAATVKPSREERGGRESGSSTDGEESDHGSDRSLSPGEGAPVDLLYGIHGKQGVTSVTYHKGYVYSTGRDGSFQQLCVLGQQLRPLWKQKPCKGMDWVAGLSFAPDENLLVLGFHSTDFVVWSPRTHEKLHKVPCGGGHRSWGYTSTPATMVFAYIKAGDVMVYQAQEGGSSCQAVLKESLHGRELTCVRYVGSMKTQEGSNTTDILVTSSEDTTVNILAFVAASSTVFLLATINNHISSVRTLALCEANTNGGEAETGLRALLFSAGSRAEMQCYQLLVMPDLTTQAGLTCRVTHLISHRLDEHWDRQRNKHKVIKMNPETRYMSIVVVTSPQQSGFGLVLAAACSDGSVKLFLVDELARKLQLLAESFYHQRCVLKIQTFTYEAGTGTR
The following text describes a protein:
Function:
May play a role in chloroplast biogenesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MEAKLLKPAFYNSPNLNLTNSSRLISRLSIWNDKSKVGLSSGSLFLRLSAASPIRYSRGLLRVDESEYLKLESIRHSLIRQEDSIIFNLLERAQYRYNADTYDEDAFTMEGFQGSLVEFMVRETEKLHAKVDRYKSPDEHPFFPQCLPEPILPPIQYPQVLHRCAESININKKVWNMYFKHLLPRLVKPGDDGNCGSAALCDTMCLQILSKRIHFGKFVAEAKFRENPAAYETAIKEQDRTQLMQLLTYETVEEVVKKRVEIKARIFGQDITINDPETEADPSYKIQPSLVAKLYGERIMPLTKEVQIEYLLRRLD
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MASVELEQQVDDLTVSKVTPFVEKNIDELNSLVQLMFTPSAPDIHCTQKLSKSQNTKLIQYKIRLEKTRSRILVLIDNYITHEEKLSHFLGLLDRIDDILTTIKIMSGEDEELNFTLPPTTNNNNNNTTNVLESSSDSDYDIIQPREFLKKSKPNLILSTKNSLSSLLKRKKSKNQITTTTTTTTTTANNNNTRRNRNNNNNNNNNANGANRTIDTSSEDDDESISSSDDDIVIGSRRSRAATISYLPNVPRANPTPINGRTPTPSHNFEPFTINTFLNSVNGVNKTSTTSTTTTTTTTTTAAGRTNKTVNRNNNNNNNNNNNKRFEIESEEESETDISSEEEENNNNNNNNSNNNNNSNNNNNLKLKTKSMSFTKNGIPLKIRSRINSESESEPENQLAESYELGKCQRKHISTPSLRLSSAHLPNTTTTTTTTTTTTTTTTSPKSVNNNDDDESSDSDSSDSEIENIKQTIKKNNGPPSPMTTEIIIGYSGHSKRLCNRYSLPTVQKSFTKQQLHEEIINFGRTPSRIKQSFLKPVNGDAELVFEYDDSEEEEEEEEEEEGEESDSESSSGSEGEVIVESFGIEKKVLRQYIKLKKEMEDRKKVSTKLEEPVECKICYMEYDQSNEVFTLECDHVYCFDCITEHLRILITEGRVLDISCPHPQCKKEIKESEIYMLTNEKNWLKYQKFSMIASLKTEPIKWCPTPDCDTPVRGGSERNPILNCPKCSNDFCWICGEYSHEGAKCGTEAMELQGRKNKSIESAATAYIDFLESNKHFVKPCPTCKSHIEKHDGCNHMTCINCQHQFCWLCMNPYQSGHYSSNEYPECFDRQYYSPFVPDTYTPPPPRRRHRKLKMAKKITLYTAAFTVGAPLLLIGGAVLLCVKIHKHRKNRARRNRNVGLY
The following text describes a protein:
Function:
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MQTRYDVIVVGAGHAGCEAAHAAARLGCRTLLLTIDLDKLAHMSCNPSIGGPAKGHLVREIDALGGLMGRITDRSAIQIRLLNESKGPAVQSLRAQCDKRLYARLMKETLERVPNLDLRQAMVERIAPPNADTQCFTVTTHTGWRYLAPAVILTTGTFLRGRAITGEAMWGAGRAGEAPAMALSEDLAALGFPLVRLKTGTPPRLAAATIDFSLTELQPGSDTPLSFGHYYPELGETIPPPEYHGPPAPVYPHPQLDGWRPQLPCYQVHTTPEFHAIIRENLHRAPLFSGIIEGVGPRYCPSIEDKIVRFADKERHGLFLEPEGWTTSEVYVQGCNTSLPEDVQWAMLRSIPALRNVELMRIGYAIEYDAVATGEITADMQTRRLRGLFFAGQINGTTGYEEAAAQGLMAGINAAHYVQGKPPVILGRAEAYIGVLIDDLTTKEIREPYRMFTSRAEYRLLLRGDNADLRLTPLAYRLGLVDGERAAVVEARRQQTEHALQQMRERRIFPSAAVNASLEAHGIKPISQPVTVAEVLARPEVRYTQLRDALPDLPALSDAVIEQVEIGCKYSGYIARQEREVARMQKMEHRRIPPDFDYTSLPGLRNEARQVLMRFRPATLGQAGRLAGINPADVAIILFALERRQGDQVAR
The following text describes a protein:
Function:
Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPCSTHGDALANCQTVSSNDHGNGTDNNYINETKTSVGFTFMDTASNSPVTTKPINNSNIAVYDSPSNNNWTDLFSTVDSMLASSPSGNGTIGASGGGGAGGFGSEVMIPLYSVIFILSVLGNILVIVTLTQNRRMRTVTNVFLLNLAIADLLLGVFCMPFTLIGQLLRDFIFGSFMCKTIPYFQAVSVAVGVWTLVAISLERYFAICRPLKSRIWQTRSHAYKMIIAIWILSLSLCLPVAVLSRLKPIRETGRHKCREEWPDAVSEKVYNLLLDVILLVLPLLIMGLAYWLIAARLWRGLRHETSSSVNTNTGSRLQTMMAAAESSAPLENICGSSCTVYEYMGPTEIALTQLLAYLSSCCNPITYCFMNEKFRNAFLSAFGCGPQGRGFGRAPNRSTDLLSASFNDSFNLGRRTTNKGK
The following text describes a protein:
Function:
Required for 27S pre-rRNA processing. Has an early role during 60S ribosomal subunit assembly.
Miscellaneous:
MISCELLANEOUS: Present with 1660 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGDLTEELSIPDNAQDLSKLLRSTSTKPHQIAEIVSKFDKLETYFPKKEIFVLDLLIDRLNNGNLDDFKTSEHTWIIFTRLLDAINDPISIKKLLKKLKTVPVMIRTFFLWPKDKLLTRSVSFIKAFFAINDYLIVNFSVEESFQLLEHAINGLSSCPTTDFALSYLQDACNLTHVDNITTTDNKIATCYCKHMLLPSLRYFAQTKNSASSNQSFIRLSHFMGKFLLQPRIDYMKLNKKFVQENASEITDDMAYYYFATFVTFLSKDNFAQLEVIFTILGAKKPSLECRFLNLLSESKKTVSQEFLEALLLEMLASTDESGVLSLIPIILKLDIEVAIKHIFRLLELIQLENLNDPLFSSHIWDLIIQSHANARELSDFFAKINEYCSRKGPDSYFLINHPAYVKSITKQLFTLSSLQWKNLLQALLDQVNHDSTNRVPLYLIRICLEGLSEGASRATLDEVKPILSQVFTLESFNNSLQWDLKYHIMEVYDDIVPAEELEKIDYVLSSNIFDTTSADVEELFFYCFKLREYISFDLSDAKKKFMRHFEILDEERKSNLSYSVVSKFATLVNNNFTREQISSLIDSLLLNSTNLSSLLKNDDIFEETNITYALINKLASSYHQTFALEALIQIPIQCINKNVRVALINNLTCESFCLDSATRECLLHLLSSPTFKSNIETNFYELCEKTIMSPEMAISETGDEKKEIEDKISIFEKVWTNHLSQAKEPVSEKFLESGYDIVKQSMSLSNGDSKLIIAGFTIAKFLKPDNKHRDIQGMAISYAVKILENYSENFESETIPLFRISMSTLYKIITTGQGDISKHKSRILDIFSKIMLRYHSKKVYHAPEEQEMFLVHSLLTENKLEYIFAEYLNIEHTDKCDSALGFCLEESLKQGPDAFNRLLWNSAKSFSTISQPCAEKFVRVFIIMSKRIARDNNLGHHLFVIALLEAYTYCDIEKFGYKSYLLLFNAIKEFLVSKPWLFSQYCIEMLLPFCLKTLAFIVNHESTDEINEGFINIIEVIDHMLLVHRFKFSNRHHLFNSVLCQILEIIAIHDGTLCANSADAVARLITNYCEPYNVSNAQNGQKNNLSSKISLIKQSIRKNVLVVLTKYIQLSITTQFSLNIKKSLQPGIHAIFDILSQNELNQLNAFLDTPGKQYFKALYLQYKKVGKWRED
The following text describes a protein:
Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MMVPVRCFSCGTVVGEHWEAFKARAETHDGDEDPADVLDDLGVDRHCCRRMLIAHQDLVDVVSPYQ
The following text describes a protein:
Function:
Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Secreted, extracellular exosome.
Sequence:
MRRAALWLWLCALALSLQPAMPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTWLLTATPMSPEPTGLEATAASTSTLPAGEGPKEGEAVVLLEVEPDLTAREQEATPQPTETTQLPTTHQAPTARATTAQEPATSHPHRDMQPGHHETSAPAGPGQADLHTPRTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAIVAVEPDHRNQSPVDPGATGASQGLLDRKEVLGGIIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA
The following text describes a protein:
Function:
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
Sequence:
MSKRQMLMLADVQSVENTCKTDPACPFVAFEKSKNTFGFTLAANGEVVIYTFSMGDDYPDNTVLTYSHCPDQPLLIHERIPTFFNTISPKYWKNPKCVNPLPRVGIQEPDETTDFWLNEDSPSSDMDVNIPANEDGDDTNDSDYDDDGEDDNDVDEDYYNTDGEDIPEYFSDEDEQVKMHPLLAHDIEQVKQLAGNQAISYRMFDALGDIDIDLQLDVSFLQDLIAKAWCLNREQPLVVRLHCSLSKYLDENSPQVSVFQSSKSNQPGVCSQMKKITESFLLGHWKSLTNKAVLAHLKSREKSPSKTCQRDGHRNHSNTSRGRTLTIPISFSRSSSSMSQSPSSESPSPVSPDSSSKKFGKKMFPWQPWQRSSSTGHSPPSPGKEELHLIPAATQDQKQAKQIPSLEHGFLWQMYGYLKNRIPNLSEFCVVCDEPHIFQNGAMLKPAVCERELCVFSFQMLGVMQDAAENIATGAEVVDLLVSMVLAAVKSRRRQLILDPFPSVVDPKSSKELAFSPKKKNFDRLESTLDKFSSMTDMLAAGSVTDMKKQMDRMDFMAYPLLQWIISSNRSHIVKLPTNKQIRFMHTPHQFLLLSSTPSKEIAFRKAKQEHGSIFAFHGSNIENWHSILRHGLINASGTKHQMHGAAYGKGIYLSPHSSVSFGYSGMGHGIHQPVKKLPPVQEPKKSACRFLQSKNLRCIALCEVISSKELNRHGHVWVCCNPDHVCTRFFFVYEDGKVGDQGVDTTQDKYTKDILSAMADWRTL
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAHTTPRSHPPPHSLLQNLTTQSLLLSHLFTLIASPPNPNTSTQTQLNQVYSALQLSTLDLSGLVKEVGHHQEAYRRLVEKKNEVAGLEMRVRGLVKRLEEGRKELEGMIDQGERSLEDIEKSEREPVPAKTLMAHAQSLSKHSSAPVSSLLAPVDKAQYAPWPTEMSMRMGLLFQLEGSMSGMGERGVVGEEQKAPQKVEERREHVEHEESDRRYDPNAVFQLDLNSDESDED
The following text describes a protein:
Function:
Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.
Subcellular Localization:
[Isoform 1]: Secreted. Note=Secretion depends on EGFR activity; [Isoform 2]: Cytoplasm; [Isoform 3]: Cytoplasm.
Sequence:
MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
The following text describes a protein:
Function:
Required for chloroplast division. Together with MIND1 and ARC3, regulates FtsZ ring positioning in chloroplasts in an ARC6-dependent manner. Determines the site of chloroplast division in concert with MIND1. Not directly involved in ring formation, but required for MIND1 and MINE1 localization to regulate FtsZ ring formation during plastidial constriction.
Subcellular Localization:
Plastid, chloroplast inner membrane; Single-pass membrane protein. Note=Localizes at the chloroplast to a ring structure at the constriction site and on the punctate structures of the envelope membrane throughout the chloroplast division.
Sequence:
MASIDSLQFHSLCNLQSSIGRAKLQNPSSLVIFRRRPVNLNWVQFETKGSFVCKAIGDSSTPDEDIQNTQSDDNVVVVTATTQSDIPHDSEYSISRFRSMVTTLPPVVFLMKKCSVNSIWIGVCITATVLVAAIRAYVVRKSRDNQRAGSVADLVRRGQLRSGDRRGISKSLNYEDPFNNPFVKLDKGSSTVEMCGKVYRLAPVTLTEKEQTIHQKRRSRAYQWKRPTIFLKEGDSIPPDVDPDTVRWIPANHPFATTVSDIDQDLAQNNVYQKQGVPFRIRAEHEAMQKKLEALQNEEKLNNLSIDSQNARDFQRPYKFSAKLEGENIQKNSQENHTGNSSSEETHKS
The following text describes a protein:
Function:
Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
Sequence:
MLTAFVGLGANLGQAEATVRAAIVALGTLPQSSVTAASRLYRTPAWGREDQPDFINAVAAVRTALAPLALLDGLLAIEQAFGRDRRDGERWGPRTLDLDVLLYAEQVIDLPRLQVPHPHLHARAFALVPLAELAPEAIIPGHGTVRHALQGVDGCGLEPIG
The following text describes a protein:
Function:
Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of specific genes in the developing lens. Also required during spermatogenesis.
Subcellular Localization:
Cytoplasm. Note=Localizes to cytoplasmic RNA granules.
Sequence:
MQEPDLVAKALRSVLHSSKHGIPLSELQDEYRSLTGEWIPFRHLGYATLEAYVASIPEVVRIERNQTGEVTCHAVACPETIYVRVWAVAHKRTSPIFLLFCCRQNIEKTLQMIRVLDICAIFKDPRWSSEVSFVVSVSVCLRRDQLSHHGFKRSCTFTCPEGLPLIQMVSFPIKSILSEKGLIPAYEKNHSNSEFYFSLTDNLNASGVETHTVASGRSVPNISEIQNRIKEILSKYRNGVWLSKIAQVYEETYREELSTTVLRQLEHWPHVCTVEKVRTGDQTYRILYPSKRIPPAVKSNTEQDQASQNVTSSKAGPVLKTSREAESASCSSDFKQNVVNILVKYPCGLWADALPKLYQDAYQRKFPEGILNNLQLLSDVCVVDYVSNVPQKAILYVKTQSCTDENLNVTEKVQIPDGAKATAEQQHEESKEQYPESISSVPPLVIPSEGPVSVLVIDVNNPNELIIRYVGKDYSGAQEQMEDKMKAYYSKNSTASQITFPSVGQLVAVHTEEEAWLRAQIISVEDKRLKLSCFCTYFGCITFRMCKPKENTHCCMKQCTSHKCKLTGLEVFSDDPLLLKAVELQAYHKICAVEILERSDIPVFVLYDTSGEDDININATCLKALYDKSFELNLQVDTLYTNVRVTSILSDGNMYCQLPSEGLSKLSEVLQKIEYYLLHQETSEFNVSQPYCGKICLFLCKGKWTRVEITIIHSRRALGVRFIDTGRVAYVKVTDLREIPSQFLREVIKIPPQAIKCCLADLPPDTGMWTPEAVLWLRDNVMDYAEFSMQVSVMEKRCVLKFWKAFIPISYLLADRSINRRINAVLWKHQKDVFLSVTSQGLAPPKHLNQGRLEKSDSLEPAVESRGVESATDVPPPLPLSEVGGFMDVYVSVACHPGHFIVQPWKEIHNLEALMEEMILYYSMAEERPVNIGTNKLYAAKIENRWYRVIVKGILRKGFLSVYVLDYGKHEVISIDKVQPLLDKFRKLPFQAIKAELAGVKSQQWSEEASIIFRNRVEKKPLVAQIQAINESTNSWDRKVVTYLVDTSIPDTDVWIHDFVCQSLAELSEAD
The following text describes a protein:
Function:
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Subcellular Localization:
Cytoplasm.
Sequence:
MDIGKIDIPESSGVYLMKKNNKVIYVGKAKNLKNRVSSYFNRVHESEKTNELVKNIEDIEFFLTNTEIDALLLENNLIKKYSPKYNILLKDEKTYPFIKISKEDFSSIKIVRTTKALDIKSGEYFGPYPYGAWRLKNILMKLFKIRDCNRDMKKTSPRPCLKYYMKSCTGPCVYKDIKEEYNKDVENLKQVLKGNTSKLINELTALMNKASQDMDFEKSIIYREQIKELKSIASSQIIQYERELDEDIFVFKTILDKAFICVLNMRDGKILGKSSTSIDLKNKITDNIYEAIFMSYYSKHILPKSLVLDAEYENELSVVVKALTIEDSKKKEFHFPKIKSRRKELLDMAYKNLERDIESYFSKKDTIEKGIKDLHDILGLKRFPRKIECFDISNIQGKDAVASMSVSIEGRAARKEYRKFKIRCKDTPDDFSMMREVIERRYSKLPDIEFPDVILIDGGLGQINSAGEVLKRLGKIHLSELLSLAERNEEIYKYGESIPYVLSKDMEALKIFQRVRDEAHRFGITYHRKIRSKRIISSELDKIDGIGEVRRRKLLTKFGSISAIKKASIEELKEIIPEKVALEIKNKIR
The following text describes a protein:
Function:
Dual substrate-specific glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase, catalyzing the first and committed reaction in the de novo synthesis of glycerophospholipids and triacylglycerols (TAGs). Prefers Gly-3-P over dihydroxyacetone phosphate and has a marked preference for 16-carbon fatty acyl chains. Transfers a fatty acid from fatty acyl-CoA to the sn-1 position of glycerol-3-phosphate to produce lysophosphatidic acid (LysoPA). These lipids not only are precursors of glycerolipids, but also are dynamic components of signal transduction systems that control cell physiology. SCT1 is the primary supplier of diacylglycerols (DAG), used mainly in TAG synthesis and phosphatidylcholine (PC) synthesis through the CDP-choline pathway. Regulates fatty acid desaturation, that is, the ratio of unsaturated versus saturated fatty acyl chains, by competing with the desaturase OLE1 for the common substrate C16:0-CoA. Sequesters C16:0-CoA into lipids, thereby shielding it from desaturation by OLE1.
Miscellaneous:
MISCELLANEOUS: Present with 1050 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to both perinuclear and cortical endoplasmic reticulum.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MPAPKLTEKFASSKSTQKTTNYSSIEAKSVKTSADQAYIYQEPSATKKILYSIATWLLYNIFHCFFREIRGRGSFKVPQQGPVIFVAAPHANQFVDPVILMGEVKKSVNRRVSFLIAESSLKQPPIGFLASFFMAIGVVRPQDNLKPAEGTIRVDPTDYKRVIGHDTHFLTDCMPKGLIGLPKSMGFGEIQSIESDTSLTLRKEFKMAKPEIKTALLTGTTYKYAAKVDQSCVYHRVFEHLAHNNCIGIFPEGGSHDRTNLLPLKAGVAIMALGCMDKHPDVNVKIVPCGMNYFHPHKFRSRAVVEFGDPIEIPKELVAKYHNPETNRDAVKELLDTISKGLQSVTVTCSDYETLMVVQTIRRLYMTQFSTKLPLPLIVEMNRRMVKGYEFYRNDPKIADLTKDIMAYNAALRHYNLPDHLVEEAKVNFAKNLGLVFFRSIGLCILFSLAMPGIIMFSPVFILAKRISQEKARTALSKSTVKIKANDVIATWKILIGMGFAPLLYIFWSVLITYYLRHKPWNKIYVFSGSYISCVIVTYSALIVGDIGMDGFKSLRPLVLSLTSPKGLQKLQKDRRNLAERIIEVVNNFGSELFPDFDSAALREEFDVIDEEEEDRKTSELNRRKMLRKQKIKRQEKDSSSPIISQRDNHDAYEHHNQDSDGVSLVNSDNSLSNIPLFSSTFHRKSESSLASTSVAPSSSSEFEVENEILEEKNGLASKIAQAVLNKRIGENTAREEEEEEEEEEEEEEEEEEGKEGDA