lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional regulator of sporocyte development. Acts as an adapter-like transcriptional repressor recruiting TPL/TPR corepressors to inhibit TCP transcription factors. Required for nucellus and embryo sac development. Plays a central role in patterning both the proximal-distal and the adaxial-abaxial axes during ovule development. Involved in establishing the prospective chalaza of the ovule and in controlling the cell number and the length of the funiculus, and is required for the development of the integuments. Required, with BEL1, for cytokinin-induced PIN1 expression in ovules. Involved in controlling stamen identity. May also regulate the morphology of lateral organs by repressing auxin production.
Subcellular Localization:
Nucleus.
Domain:
Contains 1 EAR motif required for the interaction with TPL and TPRs.
Sequence:
MATSLFFMSTDQNSVGNPNDLLRNTRLVVNSSGEIRTETLKSRGRKPGSKTGQQKQKKPTLRGMGVAKLERQRIEEEKKQLAAATVGDTSSVASISNNATRLPVPVDPGVVLQGFPSSLGSNRIYCGGVGSGQVMIDPVISPWGFVETSSTTHELSSISNPQMFNASSNNRCDTCFKKKRLDGDQNNVVRSNGGGFSKYTMIPPPMNGYDQYLLQSDHHQRSQGFLYDHRIARAASVSASSTTINPYFNEATNHTGPMEEFGSYMEGNPRNGSGGVKEYEFFPGKYGERVSVVAKTSSLVGDCSPNTIDLSLKL
The following text describes a protein:
Function:
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal glycosyl residue.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MPSSPKPHHHHGRPSPPSPRRSTMLIVSCCLLVGFSGFVLGFIAILGPGRGSRCSGAEPRLLRVSWSGEARDGGGGLLVRDGGKVLRRRKVKGFVGIQTGFGSVGRRRSVRRTWMPSDREKLQRLEEDTGLVFRFVIGRTNDRTKMMELKKEVAQYDDFLLLDVEEEYSKLPYKTLAFFKAAYALYDAEFYVKADDDIYLRPDRLSLLLTKERSHSQTYIGCMKKGPVFTDPKLKWYEPLAYLLGKEYFFHAYGPIYALSAEVVASLVALRNNSVRMFSNEDVTIGAWMLAMNVHHENNKELCQPECTSSSIAVWDIPKCSGLCSPEKKLLELHQKEICSDSPAVASDD
The following text describes a protein:
Function:
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Midbody, Midbody ring. Nucleus.
Sequence:
MKPTRGKTPKKTPRRPQQSNKPKDPVEVYCRLRPPNEEDVCAEVLSDGVLLLRPSEAARVNRIGELKETQHTFKFVFPPETSQKTLFDVVALPLVQDVIQGRNGLLFTYGITGSGKTHTVQGTPADHGLLPRCLDVIFNSIGELQAKRCVFKPDKVNGMDLQTEADAMLERQRKLQQDLLVPPKTPTTPRRNNVGDDWQNFPYVADPTKVDAVDEDNAYAVFVSFIEIYNNYIYDLLEEAPTSMPSTPRGPLKYQTDDGNGIAPQSKILREDMNHNMYVYGATEVEVKNPEEACEQLIKGQKRRRVAHTQLNMASSRSHSVFLIRVAQAPLDPEGEEVLQDKSQVCVSQLALVDLAGSERTNRTKNTGDRLREASNINASLMVLRTCIEILRENQTSSANRIVPYRDSKVTHLFKNYXEGEGKVRMHVMRFAELTQEVEITRQKEVRFDTGLTPGRRKANQMYREALEKFERGEQDANFMLPGRPGYSLGPPWPCLELTSASDSITLQTLIQYLVDREACRRTLCDDLSRKRKVFGLTVFCCVLQNEVLRRTAQLYDEEKKEMESELKSKEHQISSRTAESRRLRQTMKAIEQTKDAKWEKECDRRMKQQRMELQNKMWVKEEKLRQLKEIVSHKDGKRRAKSPPPKPTAPPVRLNHRRSRSASGDRWLDHKPVCNLDTETVLQPHLKKKMTVSVPDVKNIKKTDKYMLTHQEEDSQGEIETKLIKGDVFKSRGGGHSVQFTDIEVLKQEAPPESRKRSASEDIAEEHTGDWTDVEERCAIAVEGHDRRASAKRHKV
The following text describes a protein:
Function:
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Membrane, caveola.
Sequence:
MQMSFSVSLTPFGSCPRLGASKFVCGPRTRTGLAQARGRAWRVVVSHASSWVALRLRQDPAPGISLTLAISQVQALSCPTPRCPPASQEPPPAPTPPQTHVTAQGGASAAAAAALRPELAASASPRSPAPRPRGANPRARCLAPPRRPPRRAPLPPPAGPPVRQAGKQAGSRSERPSALQPFRAAPSLLLPGQRRRLHRQRRGPSGRRGVGRAAAAERRGQRGGGGGRAPNMAAAAAAAAACAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
The following text describes a protein:
Function:
Transcriptional repressor that may regulate multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing OFP10 have no visible phenotype.
Subcellular Localization:
Nucleus.
Sequence:
MLNLQAKLNEKKVPLLTNFPTPTSSLNNLNLFSLPLVKKKMSFKKMMKYILKTIFKPIFMACGCGSTVPPSSHSHYTPGPPVSPTVLRSPCPKIDESVAMAKESINPFEDYKKSMNQMIEERYIETESELKELLRCFLDINPSPQHNLIVRAFVDVCSHLQPPHDRRGKSLGRLLRLYVNNPLDNNDDDSHQTSSK
The following text describes a protein:
Function:
Soluble adhesin with carbohydrate-binding activity. Binds to sialic acid-terminating oligosaccharides. Required for attachment of the parasite to the host cell and subsequent invasion. Ensures correct folding of MIC6 and transport of the MIC6-MIC1-MIC4 complex into the micronemes. Facilitates the correct targeting of MIC4 to the micronemes. Triggers the activation of murine bone marrow-derived dendritic cells and macrophages and production of pro-inflammatory cytokines, such as IL12 (IL12B/IL12A), in host TLR2/TLR4-dependent manner. Plays a role in the induction of cytokine storm during infection and acute death in mice. Triggers the production of anti-inflammatory cytokine IL10 in murine bone marrow-derived macrophages in host TLR4-dependent manner. Induces transient endotoxin tolerance in murine bone marrow-derived macrophages, manifested by reduced TNF-alpha (TNF) production in response to lipopolysaccharides (LPS) challenge.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, microneme. Host early endosome. Note=Localizes to host early endosomes after interacting with host TLR4.
Domain:
The galectin-like domain has been demonstrated not to bind lactose, glucose, maltose, mannose, heparin, fucose, L-arabinose, N-acetyl-D-galactosamine, or N-acetyl-D-glucosamine. It interacts directly with the second and the third EGF-like domain of MIC6, and with part of the acidic domain; The MAR (micronemal adhesive repeat) domain was at first proposed to be TSR1-like (thrombospondin type 1-like repeat) by PubMed:9027753, but PubMed:17491595 found that this domain represents a previously unknown protein fold. This domain is jointly responsible for interacting with MIC4 and for host-cell adhesion.
Sequence:
MGQALFLTVLLPVLFGVGPEAYGEASHSHSPASGRYIQQMLDQRCQEIAAELCQSGLRKMCVPSSRIVARNAVGITHQNTLQWRCFDTASLLESNQENNGVNCVDDCGHTIPCPGGVHRQNSNHATRHEILSKLVEEGVQRFCSPYQASANKYCNDKFPGTIARRSKGFGNNVEVAWRCYEKASLLYSVYAECASNCGTTWYCPGGRRGTSTELDKRHYTEEEGIRQAIGSVDSPCSEVEVCLPKDENPPLCLDESGQISRTGGGPPSQPPEMQQPADRSDERGGGKEQSPGGEAQPDHPTKGGNIDLPEKSTSPEKTPKTEIHGDSTKATLEEGQQLTLTFISTKLDVAVGSCHSLVANFLDGFLKFQTGSNSAFDVVEVEEPAGPAVLTIGLGHKGRLAVVLDYTRLNAALGSAAYVVEDSGCSSSEEVSFQGVGSGATLVVTTLGESPTAVSA
The following text describes a protein:
Function:
Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MNEQELQDLQKMVGVAVNALGDIKAKDISVLETQDKTSLFARMIIASGDSTRQVKALANNVAVDLKEAGFEILSTEGDSGEWTLVDAGDLVVHVMLPAVRDFYDIDTLWGGEKPSFHAGMQKPWHAAD
The following text describes a protein:
Function:
May be a transcriptional repressor.
Subcellular Localization:
Nucleus.
Sequence:
MDSSSFIQFDVPEYSSTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNVFEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILESIHSKISVGDVDSVTVGAEENPESRNGVKDSSFFANPVEISPPYCSQGRQPTASSDLRMETTPSKALRSRLQEEGHSDRGSSGSVSEYEIQIEGDHEQGDLLVRESQITEVKVKMEKSDRPSCSDSSSLGDDGYHTEMVDGEQVVAVNVGSYGSVLQHAYSYSQAASQPTNVSEAFGSLSNSSPSRSMLSCFRGGRARQKRALSVHLHSDLQGLVQGSDSEAMMNNPGYESSPRERSARGHWYPYNERLICIYCGKSFNQKGSLDRHMRLHMGITPFVCKFCGKKYTRKDQLEYHIRGHTDDKPFRCEICGKCFPFQGTLNQHLRKNHPGVAEVRSRIESPERTDVYVEQKLENDASASEMGLDSRMEIHTVSDAPD
The following text describes a protein:
Function:
Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).
Sequence:
MTSKAKPNPKHLVQGDPIPPLKKGVPRLFSFRFCPFAHRSRLVLAAKNVDYELVNISLSKKPEWYKTKNPFGTTPCFEHDEKIVRDSSIVCEYVNDAYPGVNLWPEDPYRKAQDKMLLDYFGSKISPPFFKATYHPPPSSTEDFLAVYQKELYVLEEELKKRGSAFFFGEKPGLVDFIMWPWFERWAVLGEDFHRENYPTLMGYCGRMKEDPAVIEAATPDEIYQNNFKKQMEGNPQDDY
The following text describes a protein:
Function:
RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (By similarity). Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Also plays a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA (By similarity).
Subcellular Localization:
Cytoplasm. Mitochondrion matrix. Mitochondrion intermembrane space; Peripheral membrane protein.
Sequence:
MAACRYCCSCLRLRPLSDGPFCLPGRDRALTQLLVRALWSSTGSRAVAVDLGNRKLEISSGKLARFADGSAVVQSGDTAVMVTAVSKTKPSPSQFMPLVVDYRQKAAAAGRIPTNYLRREIGTSDKEILTSRIIDRSIRPLFPAGYFYDTQVLCNLLAVDGVNEPDVLAINGASVALSLSDIPWNGPVGAVRIGIIDGECVVNPTRKEMSSSTLNLVVAGAPKSQIVMLEASAENILQQDFCHAIKVGVKYTQQIIQGIQQLVKETGVTKRTPQKLFTPSPEIVKHTHKLAMERLYAVFTDYEHDKVSRDEAVNKIRLDTEEQLKEKFPQADPYEIIESFNVVAKEVFRNIILNEYKRCDGRDLTSLRNVSCEVDMFKTLHGSALFQRGQTQVLCTVTFDSLESGIKSDQVITAINGIKDKNFMLHYEFPPYATNEIGKVTGLNRRELGHGALAEKALYPVIPRDFPFTIRVTSEVLESNGSSSMASACGGSLALMDSGVPISSAVAGVAIGLVTKTDPEKGEIEDYRLLTDILGIEDYNGDMDFKIAGTNKGITALQADIKLPGIPIKIVMEAIQQASVAKKEILQIMNKTISKPRTSRKENGPVVETVQVPLSKRAKFVGPGGYNLKKLQAETGVTISQVDEETFSVFAPTPSALHEARDFITEICKDDQEQQLEFGAVYTATITEIRDTGVMVKLYPNMTAVLLHNTQLDQRKIRHPTALGLEVGQEIQVKYFGRDPADGRMRLSRKVLQSPATTVVRTLNDRSSIVMGEPISQSSSNSQ
The following text describes a protein:
Function:
O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MISLSLTKMHACKLCGRMFRVVLRSNRALLSRFNGVLDSTGRNTSVRSCSSTAYPSSDSVNESGTKQKKTSINPEEVKKFNALASKWWDTKGELKGLHSMNRLRVPMIRDTLVKHHSISKKSRPLEGLRILDVGCGGGILSVPLAKLGAQVTGLDASEEAVKAATAHMARDPSLKDTLTFTHGTVEDLVASEVRDYYDALVASEVIEHVDALDDFVGSSCDLVKPGGSLFFTTINRTTQSYYLAVIAAEYIVGVVPRGTHNWNKFVKPEELKDELKANNCHPRLIHGMFYNPFLNRWNWTGSTEMNYALHAIKEPEL
The following text describes a protein:
Function:
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSGWWSSKSPFASLVERATSETLPTGSEDFELNLSVSDEIRSKRVPAKTAAQTLKTRINHRNPNVQLLALKLTDTCVKNGGTHFLQEIASREFMDNLVSILHAPTGVNHLVENQILSFIQALAVATKDRPEPGLSYINQVFERLKNEGREFPALDTSITSSFLDSSAPPDWADSDVCMRCRTAFTFTNRKHHCRNCGNAFCGLCSSKMKTLPHLGITEPVRVCDGCFSRPQNARTTNARPASLPRRPVPSAQQQPSGRSSKQQEEEDLRRAIELSLQEPRSGRASTFQPARANAPTTAVTDDEDEELKRAISLSLEEAQREEEKRKSATTSAPATTQRPSSNDAFSYPSVPEHTASVSSTTSSPFMPPRPSIPTASPTPPSHSSNKLSDISSADADQIALYVALVEKLKRSPPGTIFTEYKLQELHDAMRDMRSRLMRALGVAMSKHNQLLEATDKIQSCVKLNDSLIKQRMDMTVGRNRPAYEQTDDHNYGIARPASPLHRPTEPERPAVPTSAPVSTPVPASAPAPAASASASTLTVDTRPPSPKSARPAGPRTPIVIVQTPEETEAEAALFSAPPAYSKDDKHSSATAPEKQNNNTQEEDTDLSTIAPYYTDISPSSHQQSQTSAGATSVQPSSSNANSSSVSRTDEAGAIENLYYSQSLRTRREVPMRQSSPRQHRQQQPPAEEKPSVVEASLIEL
The following text describes a protein:
Function:
The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MYSRLFFSILFFLGCCPALFADTDSPQRATFGQPAVMLGIAIVFFYFILWRPEQKRRQAMEKRKSELAVGDKVTAMGIVGTIAEIREHTVILNIASGKIEILKAAISEILKAEK
The following text describes a protein:
Function:
TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription. Regulates the genes involved in ubiquitin-dependent proteolysis during the progression of M-phase of mitosis.
Subcellular Localization:
Nucleus.
Sequence:
MAQSSYSSGNSTSDLNKIVLDYLFKKGYSRTEAMLRLEISSVGAIPEEQQDWHIGASETYVQVYILLRDWIDGTLDLYKPKLQKVLYPIFVHSYLDLLQKNDPEMAIYFFESFRIEHEVLHGYDIRALAQLKIASDVEEIEIAQLYRKNKYRINFTRSTFDLLVQFLFENEVNGSGIIIRLLNQYIDIKITMPQVEGKEDPNVQAVYEMDEAKNEQTIISEQEGIPGHSEQLLDYNKQSIQLGLRPLSEEVVTTLKNLLEVKDKDVEGRNEALNKILHPAKNLVELLTEKENLINESTLESPSDPPLPPTKMKDIDYFVSLLESEQNSLILGKNATDPSVFMYTMHNTLSAVNCAAFSDDASMFALGCADSSIHLYSSTNNGPQPLVGSQNEPLQKSSLIGHTRPVFGVSISPQKEFILSCSEDGFTRLWSKDTKSTIVKYAGHNAPIWDVQFSPFGYYFATASHDQTARLWDVEHAAPLRVFVGHQNDVDCVSFHPNAAYLATGSSDHTTRMWDVRTGGTVRVFNAHHSPVSALCMSADGLSLASADESGIIKVWDLRSSNQHVSFVKHSSIVYSLSFSYDNKILVSGGADTDVNFWDLTYRNNLSDGEQSPLLFNFKTKNTIIQNLSFTRRNYCLALSSS
The following text describes a protein:
Function:
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
Sequence:
MTATWSVNKKIFLQNAITVKNNQPLMAVVKNNAYHYDLEFAVTQFIHAGIDTFSTTSLREAIQIRQLAPDATIFLMNAVYEFDLVREHQIHMTLPSLTYYYNHKNDLAGIHVHLEFENLLHRSGFKDLNEIKEVLKDHHHNQNAKMIISGLWTHFGYADEFDVSDYNVERSQWMEIVEALLSEGYQFDLIHAQNSASFYREGQILLPHHTHARVGIALYGSRPYSSLNQHDIVQSLTLKAHVIQVREVQAGDYCGYSFAFEVTKNNTKLAVVDIGYGDGILRTRAKHEALINGKRYPIRALMMSHMFVEVDGNVHAQDEVILYNNDIRIDEYTFKGVGANSEQLSAMNHDSLKKEYISNDC
The following text describes a protein:
Function:
Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.
Subcellular Localization:
Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Found on the monocyte and granulocyte surface.
Domain:
The fibrinogen C-terminal domain mediates calcium-dependent binding to carbohydrates and tethering to the cell surface in monocytes and granulocytes. The domain undergoes a conformational switch at pH under 6.2, and looses its carbohydrate-binding ability.
Sequence:
MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA
The following text describes a protein:
Function:
Required for assembly of smooth septate junctions (sSJs), together with mesh and Tsp2A. May be important for barrier function of the midgut epithelium.
Subcellular Localization:
Apicolateral cell membrane; Multi-pass membrane protein. Cell junction, septate junction. Note=Specific to smooth septate junctions.
Sequence:
MVSVETVGSIFIKALKLIINLVIIFLYRWGDGGEFLGIGGTWNLNEEKSADAEIVASGVMVGFLIYTGCHTIAFAFGTTKHKGELCDTIMNVVGCIMWIAVGGVALHYWKGYMSDEGFLYVNSERQVGIAMGSLCVIEGALYLLDTVLACIHYSKGDTDYTQ
The following text describes a protein:
Function:
Tubulin-folding protein; involved in the final step of the tubulin folding pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
EDILASFVEKNTDSENSERNSALKELKERLEDRNESRVLNLQQKHKEEESEKVTEEKSDFFTQNFEKEAALLEEMLLCNGIEKTDRLLVVDHFDAITASFSRLQKFFSDSIMFLPKYKSRKAKSQLTELQAKIDLKRVEMIPKKKFAFKSKSKKAERKTEPDVETTSKPVKTAGEIMMAKLCKEFQVKDKMGETIEMNENEINQCDVSISNLKNCTVRLRGAPGTVHISDVQECVISIGPVSGSVFVDRCTDSRIATGCQQLRVHHTKRTDFYLHVTSRAIIEDTTEIRVTPYNLNYSELDSHFKLSGLDQSTNNWQNVDDFNWLAMSTPSPNWSVLDKNEQKVEW
The following text describes a protein:
Function:
Reversibly catalyzes the synthesis and degradation of trehalose from glucose and alpha-D-glucose 1-phosphate. The equilibrium lies in the direction of trehalose synthesis.
Sequence:
MAPPHQFQSKPSDVIRRRLSSAVSSKRPNIPGYTSLTPMWAGIAGAVVNNNTQFEVAISIHDSVYNTDFASSVVPYSPNEPEAQAGIIEKHVLETLRKFSTEHMCKFLGAGVTVILLREAPNLCTRLWLDMDIVPIVFNIKPFHTDSITRPNVRHRISSTTGSYVPSGAETPTVYYDPAQLQDPNKLSANVQTRLPIPRTVDEQADSAARKCIMYFGPGNNPRLQIGPRNQVAVDAGGKIHLIDDIDEYRKTVGKGTWNSVIKLADELREKKIKIGFFSSTPQGGGVALMRHAIIRFFTALDVDAAWYVPNPSPSVFRTTKNNHNILQGVADPSLRLTKEAADNFDSWILKNGLRWTAEGGPLAPGGVDIAFIDDPQMPGLIPLIKRIRPDLPIIYRSHIEIRSDLVHVKGSPQEEVWNYLWNNIQHSDLFISHPVNKFVPSDVPLEKLALLGAATDWLDGLSKHLDAWDSQYYMGEFRNLCVKEKMNELGWPAREYIVQIARFDPSKGIPNVIDSYARFRKLCVDKVMEDDIPQLLLCGHGAVDDPDASIIYDQVLQLIHAKYKEYAPDIVVMRCPPSDQLLNTLMANAKFALQLSTREGFEVKVSEALHAGKPVIACRTGGIPLQIEHGKSGYLCEPGDNAAVAQHMLDLYTDEDLYDTMSEYARTHVSDEVGTVGNAAAWMYLAVMYVSRGVKLRPHGAWINDLMRTEMGEPYRPGEPRLPRGELHVQG
The following text describes a protein:
Function:
Catalyzes the production of 7-dehydrocholesterol (7-DHC or cholesta-5,7-dien-3beta-ol) by inserting a double bond (desaturating) at the C7-C8 single bond of cholesterol. Essential regulator of steroid biosynthesis as this reaction is the first step in the synthesis of the steroid hormone Delta(7)-dafachronic acid.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MISRIPRLLFENILVPVADVLTKSVSNFAGHKSDQSYNSNATRVSTISDEEIEFYLNLKSAVLLLCLALCIAGFSVLMYFLYVLVFVPYNRVKRLGSIGYQNHEEGHLSKKDIANLVRRRRKVGDDLPPVFPNGWFRLVDSQQLEPGQVKQVTALGEHFAVFRSKSGKASILDAYCPHMGGNLAVGGIVKNDCLECPFHGWRFDGDGKCVAIPYSEKIPTFAKTKSWPCREVNKAIFVWFHCDGKEPEWEIPDISEISTGKFTYKGRVEHHANTHIQDVPENGSDLAHLSHLHVPHAMSGANLSTQYSSWWNFAEHIFKAQCIGPADGEPHISLFYLTHYLHVFKRFKLLSLNLNVYQIGPGIVHLHFDSPFGKGVFVQTLTPVEPLHLVLTHNLHASWSIPVWLGRIFLYLEAIQVDRDVMIWNNKTFEPRPKLLKEDSLIAKYRRWYSQFYTENSPRLTLKSEDGNGW
The following text describes a protein:
Function:
Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.
Subcellular Localization:
Microsome membrane.
Sequence:
MSLLPTVCIIGAGPSGIAVCKALKDKGIPFECYEAGSEVGGNWKFKNDNKMSSIYKSLHTNTHKDKMQYKDYPMPNSYAAYPDHQKISEYFINYVNHFGFRDHIFFKTPVTHVKHEEDGTWSILTEDGKQKYYDVLIVSNGHHWSQRWPKPDFPGKFTGDIIHSHSYIDPNKPIQLTGKRVVILGMGNSAMDIAVELCRPGISSKVFLAARRGAYIIPNYLFGKPLDKIATLFPVHTPFWLKSLIIKFALKLGVGNVEDFGLQKPDHKPGAAHFTISQDILVRLGRGDIIPKPNIESYNGNKVKFVDGSEEEIDVIIYCTGYDVKFPFFDENFLSAKDNHLPLFHRMVKPEFKNLFFVGLFQPLGPIAPLSEFQGKWISEYLVGNYEFPSEEKMNQSIEKYESKMKRRYITSARHTMQVDFEVFLYDMKSELKKGIKRAAKNGNKLPVPALAQNKSILSNDISVKRFKNKTELFSEI
The following text describes a protein:
Function:
Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. Plays an important role in virulence.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSFKGFKKGVLRAPQTMRQKFNMGEITQDAVYLDAERRFKEIEMETKKLSEESKKYFNAVNGMLDEQIDFAKAVAEIYKPISGRLSDPSATVPEDNPQGIEASESYQAVVKDLKDTLKPDLELIEKRIVEPAQELLKIIQAIRKMSVKRDHKQLDLDRHKRNLSKYESKKERTVKDEEKMFSAQAEVEIAQQEYDYYNDLLKNELPVLFQMQSDFIKPLFVSFYYMQLNIFYTLYTRMEELKIPYFDLSTDIVEAYTAKKGNIEEQTDAIGITHFKVGHAKSKLEATKRRHAAMNSPPPTGASSIASTGTGGELPAYSPGGYNQPYGDSKYQPPSSPATYQSPVVAATAQSPATYQSPVATGQPPSYLPQTPASAPPPQVGSGLPTCTALYDYTAQAQGDLTFPAGAVIEIIQRTEDANGWWTGKYNGQTGVFPGNYVQL
The following text describes a protein:
Function:
Mediates the conversion of kanamycin B into 2'-dehydrokanamycin A during the transformation of kanamycin B to kanamycin A.
Sequence:
MALAAPPGELTLALTPDDKTLDPASLDRALAILAEHGILVLTGMLRTRLTDQLRTAMLDDLPEVLRQQDVPTNFVPGHVQQDPPVRESLLFPDVLLNPVVYQITHAVLGADARNAVYSGNMNLPGSHEQPVHLDEPHLWPGISHPPYCLCVDVPLIDFTLENGSTEYWPGSHVLNPDECYDERGCVLPAELERRRAVAPPVRFPIPVGSVVIRDGRLWHRGVPNLSAAPRPLLAMTHYTEWFDMPPIQLPDTVKSWVDGSDRHTHAHFVAGDVDHLTGDHPFAVR
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRASLLSFLFFCSSLYCAKAASVYIGALVNTESRVGREKKVAIEIAARHYNSSSSSLLLSVREFNSGADPLEIYTKAQDLMNWGAEAIIGAGTWPEVAVLARLGSTARIPVISLATTPTPSSPMPFLVRMSYPNSGEARCLSDVVRSYNWRRVIVLYEDDSYGSISGVVPLLSDAFRAGGSRIDHHIAFPPWHTVSDDDAADTVRQKLKHVPPQLSKVSIVLRSSPELAVHLFKEAKLLGMMAKGHVWIVNDDITALLDSTDLSSSFISSYMQGVIGISTYVNTTTSFFHDFSSEFQQRFDQDLPEDGRRNSAFRVLNVVGRSYRELGFWSEGYGFFEEETEMAHGRPVVDVLRPVFWPGGTERTPGGWGMLRIGVPNHTTFDQFVKVEYDDSTGKVKGITGFCIDVFREILKHLSYDLYYEFIPFAGSYDDLVNRVPLQVIDAAVGDFTILAKRAVDVSFTEPILSSGLAMMVPLRPNHTPWMLIKPFTRDVWFLILATLIYTAGVLWYLERDSNPEFHGTWCVQLGAALWLIFSTIFFAHGRIHNYYTKTVMVVWLLVVFILTSSFTANLSSILVTEKLGAVPPGSRVGYDGDAFVLKYLKDVLGYKERNIEWIRSPEAYSEAFKSNKISAAYLETPYIRVFLSRYNDFTVSGETHRLGGFGFVFPKDSPLVADFSQVILQLAENGALNNLEKKWFSVALSSSPTPDNDRKKESLSLDSFWALFLFTGCTSTIILLVFSAHSFLLTRARAAAAVSFEPLRQSFKKVWTATAKLIEKRESPKPSEQQGSGMNSP
The following text describes a protein:
Function:
Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Sequence:
MKILRWLFALVMLIATTEAMAAGHSVDVYYGYNGDSRNIATFNLKIMMPSAVYVGEYKSSQWLMTGEILQNVSWSGPPPAPSVKLIGYHQNINKASCPGLPSGWNCGYYTFEVIVSAEIESYFSCPWLVIMNDSEASPGGVTYQGPDSHDTICPSVSVQPYDVSWNENYVSKSKLLTLQSTGGVVEKTLSTYLMKDGKLCDSTQMNETGGYCRWVAQMITFTASGCDKAEVSVTPNRHPITDKQLHDMVVRVDTSSMQPIDSTCRFQYILNEL