lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MQIKYQAIILGGGQKAGSMLFPLCQDYSKSLLPICNKPMILYQLDLLETAGFGPQDILILLTKNHQAVADLVQRRAEIFYVSEDSESGSALLEAHEKIKKDFILLSCDSMIGANILDLLDFHYSKKATITCLIKEEDLDKKQGRAPISCNLDESFDIMFIGSDQSLLHITSQEDDDQVNLQVSRNVLLSCQSVQIMTNLFDTHVYVCQYEVLELFQKLSKQELEIQNWRLEFLPYIIKHQKNVNLLNLMSKKEQGLFNERKQQQFSIKVFITQDYARRLNNIKDYQQANYESMIKGNKGISLYQTVQDFQIQNQYPQDARISPDTVIGEGTRIGNKVTIQRSIIGKNCTIGDHVKISNSIIMKNVVINSNCIIQHCILSNESAVGHATELNKCNLGTLASVEPNQKLVDECIIR
The following text describes a protein:
Function:
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Subcellular Localization:
Nucleus.
Sequence:
MDPSLLKLLEEDDEDESMHSKEDVDAFQASLIREIEGGNHSWSQQFAAWNNGITQDANTNKLHILESTQMKEQQQQSVLGSHDRELKPEDESPVQHNHNLPQNHLQPDGLSENPSHVPQATDLQSRNNSISMEQPVGSVNLGPTQLQVGELFRLLRPQVDKDRGKQLNTLFYKFKSNEVTKESFLRQARNILGERMILWAVRKLQQQGNKGVKVPDGPNHYRDPFTSAEDQSLIQSLTEDISAKKSDTYGSHDNQLHSTSSGTLSSSATVHGLHNSESPVSVNGPAMVHGGPIFPNQNNSSLPINPAPCRGSVTKDQTMSNDQTVAHVKQKLTDQSFDQVRKPCPVVRQDVSNVPMEQRNGNPRRSDDDLLKQSTEMVLSAPTTHANFASPSVKTQLDSSTMVNFSAPAATIFPGTIVTTTQGQKKTLEAQGSSLPPLSKRQKLCETSLAGSGKKFNDVTELSGINLMEEERELLSSLTKNNSRVFKSFRRVAYEEEGRTILQKAPLQRKLAGIMAKSGIKHIKDDVERCLSLCVEERMRVLLSKIIRTSKQRTDPEKCRNRICITSDIRKQINEMNQKEKDEQERKHGGEEELKNDTAKEDKRSEQLKANKEQAEKRAKAANDAALASVGGDNVFSKWKLMAEARQKPSSETRRNAKKLSGGQRLGKKNHGSPKVVRSISVKDVIAVVEKEHQMSRSTLLYRLYDSICSYVPTQDKT
The following text describes a protein:
Function:
Represses expression of the HQNO methyltransferase htm gene (Rv0560c) by binding to its promoter region. Also represses the expression of at least five other genes, including the methyltransferase Rv0558. Binds salicylate (SA), para-aminosalicylic acid (PAS) and gemfibrozil.
Domain:
Conformational changes take place in the N-terminal and the winged-HTH (wHTH) domain on ligand or DNA binding. SA and PAS stabilize a conformation of Rv2887 incompatible with DNA binding. Rotation of the N-terminal plays a key role in the dimerization.
Sequence:
MGLADDAPLGYLLYRVGAVLRPEVSAALSPLGLTLPEFVCLRMLSQSPGLSSAELARHASVTPQAMNTVLRKLEDAGAVARPASVSSGRSLPATLTARGRALAKRAEAVVRAADARVLARLTAPQQREFKRMLEKLGSD
The following text describes a protein:
Function:
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Sequence:
MGRTRENKATVISDVQELFQDAQMTVIIDYQGLTVAEITDLRNRLRPLGGTCKIAKNTLVRRALAGQEAWSPMEEFLTGTTAILVLKEDLGGAIKAYKKFQKDTKKTELRGGVLEGKSLTQADVEAIGDLPSKEQLMGQIAGGINALATKIALGIKEVPASVARGLQAHVDKE
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MDSADQSLSLLASLGDAPLLAPDSGRSSPSVRATANGMRDDEDTRLLEPVVGASVRQGLLHVKGVFPDQSTEFVDVDPRFTTIGDLKRALCERRDAARDLGLPTRDARVMFGGQLVEDAWLVMDCGMGFEGAIHIVQAGGSFLGRAGGLFGDRRTQHRADPKLSISSIASVYQSQDQPLTVDQLANDPVMNQLATFDQSLSLAAVPSAIGDLYSRHVRPEEASFAEMAADFYDNLERVQDSDLYCEKLLSGYIDVLQTRLEKMEATLAGTNKARGVSTTTQKRLQDDVQELRDERNTWRLLFELRQVCHTSKDMADGEDSLMMLGAETEELRFEMLEDDAVRLLETRNETYKIQRAVKAWLESMALEDTISISDKRGAGGSRTLRMMRKQGFPVDDDVHMDPDAVLRDGDDHILPDDTEDEAELMKAVWLYVRAGRMDDAIDLCIRLGQSWRAASLSGGNPVGASESNEREDLSLERWGNPFRALWKSMCWRLSEQAVDGKLSKSSSLLAKKYEELIYAALSGNIQVITKSSLCESWEDHCWAYLQGITEQQLDEILFKLLKVKVQSSRLIVGNNAHYLRHYSTLLDKTKYLKRYQVDLDTLFDELRGSQSEHVRIQANQPHRQIQAKLVTAKFDYIVSRILDTLLFNPEDDSYNWDLKLDSAVQSDGTSSLFLRFAAHFIMFAGFTGEHFDEQAGHMILKLYIRHLVQHRQLQFVPIYASRLPVAGAIEIYVQMLSTVDDSLERELCIKRILEYAGMDVLSAVLQSVVERLCEEYRSVALGEQQKKGQPVPSDVPTSEIDRRRIRAIEFLCFHSEHRAEALVRSNLLTRQFLLEGKFAAVKELVEENLPEDSIGVLDMHRAAQLLRDDDEIEQAMREYLCWRAYIQACAQYDLWRNCINNPGAEALSLYSEEKDYLADLMFHVSRSTAATLEVLHFENGWLMGCSNDATEDAAIRERCLPSLVFNLHFIQLESAKTIMRLNHYPEDAKAELARPLLEKSIEVADVVADEHYAVYNALDQDQCRDLLHGFRESAVSLAFVESMPTPTISPDSDQE
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MPNSSSTSQANITGSETASTSYVNYVEMSAEQEYFLYELETTDSGSMGLVLRAIYDTGDVQQFARALQQRISHYDKNIQKVCSFHYQSFVDAMQELMQLKEQCQDIKDETVQIDAEIQCISQRLCAKKQEIVRYRKLMKNAKTAMDQIAVCLPVLENYAKLQELMSNKKYYQALKTLEELEHTHLALVEKYRFTQVLAKSMTPVRLEIKDKAYSEFKDFLENIKKVAGRIGKHASKDTAEQHSFGVTDAERARKIQEEARKNASNVEIEVSADGSIVKKNVSPKRYPQAQVEDSPSFFQDDEQVSAQDLIDFTPVHRCCQIFNVLGAKEEFEQYYRQQRREQCDLVIRPSHKMNNFKHYVEYLDEIVGFFVVEDQILMTQSNLSTAAEKDKLWDNALLKIRHHLDARFGGCPDVEMMLRMKKVILLFILTMKSYGYAVAPLYELLQNFRDQYNEILVKEYCAQFERDLDKDNYTPITVNSEEEFRAVIRQFPFYKRSMEQEPFPRKFPFSRFVISAYTQAKQYLIGCLKFMDNLQLNTSAVDDTVRRCANVLLGRWAGILKSFVYKRLSMIQLVQITINLGYLEKSCESLGAFITSKTSGEEAIGTTSHQVVLSEKVFRDVRSEVEQQIDECMRSKVDEIIELSNYDWELPAAAGQASDFITDLIKFLLTTFQSFTNLPSGLAKHVCTQTCKHISQSLSDLLLSPETKAISTGALDQFSLDVMQCEMFTTRCPVVGVDPQTLSMTFADLRQLLDLVMSSDWTTFNAEYGKDHAKYLRVKASTAIVVLEKMIEYERKSTGFFGIARGDRKRLLDTIVRQLKLLEIQ
The following text describes a protein:
Function:
Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF).
Sequence:
MYDYIIVGSGLFGAVCANELKKLNKKVLVIEKRNHIGGNAYTEDCEGIQIHKYGAHIFHTNDKYIWDYVNDLVEFNRFTNSPLAIYKDKLFNLPFNMNTFHQMWGVKDPQEAQNIINAQKKKYGDKVPENLEEQAISLVGEDLYQALIKGYTEKQWGRSAKELPAFIIKRIPVRFTFDNNYFSDRYQGIPVGGYTKLIEKMLEGVDVKLGIDFLKDKDSLASKAHRIIYTGPIDQYFDYRFGALEYRSLKFETERHEFPNFQGNAVINFTDANVPYTRIIEHKHFDYVETKHTVVTKEYPLEWKVGDEPYYPVNDNKNMELFKKYRELASREDKVIFGGRLAEYKYYDMHQVISAALYQVKNIMSTD
The following text describes a protein:
Function:
Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MHWILALSLLLLLLLLVASPRLAWLKAGLLSLLLLLLSAWGLVDRLSGDGVNAATLYHLRADMDGAGVSDFSGYIAVFIGMVLLSLSPLVLLRVRRFRRPRGGGAVFGAFVVMLLVSVAVSPLYRDGKRLYYQLRPVDYATVVPEYQVPQQPLQKRKNIVWIYGESLERTYFDEATFPGLMPNLHQLATEAVDVRNLTSTEGSGWTIAGMVASMCGVPLTTAPGDENSMGRMGLFLPEARCLGDYLKDQGYRNHYVGGADASFAGKGSFLASHGFDVVHDVNYFHDKGVAPKHFSAWGVHDDVLLDDAWDSFQTLSRAGQPFMLTTLTMDTHHPAGHLPLACKNQRYESPLGDIGLLHAIKCSDRLIGRLVTRIRNSRYGRNTIIVIASDHLAMPNDLSDVLAKQKRENLLLFLGKDIPPQQVVTRAGSTLDSGATLLQLLEPGMRTLGFGRSLLANDAPPSASVAASRDSGKNYPRYLAYARTLWTGRSTRMLRVNGNGDVVVGVQQVRPPVLLEYDDNTNLKTVYLENTSRQFDRTHSDGTLAYVDRCTAFEDGSADGDWCALVVDRNQHMKLYRDPDLTRGIAVDAPLDVTPQAPRPRVRQPIMLTQAARKTEAGRYMLELYAKRRPTRAFWVEAVSSERKVVLAQQWVVPDASGRIRMPVGLEHAVEDLEIRAWLDYTEEVSVDDLALVKDTAVADRS
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
Subcellular Localization:
Membrane. Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MTFMFLLVVCLSSLLLFIGTLVMKGFVLNIFNASFSSYECGFMTMMNFKNFYTMQFFIIGLSFMLFDLEILLFLPFIYSESTNSPSIYWALFFLFIVSYLLVYELSMKVMSQW
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MDRRTVLKSTHIQQKIAEKKAELENLNEIKKFTSILTNQLDELENKLDYMAEGTESVALVLSNWQNVVKSVSLASLGLLKYSEKDYETGAPLPECLVRIKLDKDDNVGEEIQEKEEMETDDYISDQQAEESENINEEEDRQEVQTSYTD
The following text describes a protein:
Function:
Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.
Subcellular Localization:
Cell membrane, sarcolemma, T-tubule. Endoplasmic reticulum membrane; Single-pass type III membrane protein. Preautophagosomal structure membrane; Single-pass type III membrane protein.
Sequence:
MPPFLYVDVSKEDLSNSEEAHLPEIHCSIRNRRTVCHKETLLHHPTEKVSAHEEMHTSTLSQRFRSMMEPSLQDSDKTLKDDWMTADVASCGHVEDELRPSKPMIGGPHQDQSEVPKSQEDEILEMFVWDAETSQEKVLSPMTTTSSSVSDTGTGHCQNIEKSQETDQMLHDAKTSRESDLKELACDADVVNSCHQRSTENVALSGTDLYPSFEEQTNAENTLFDGDKIAGEIRKDASNTSGTCLSMQHINGREQNVMDQFGEGEILTIELKQGGIKKVENGENTGAVKANNGKTEISIREATMDTEWMVDDEEAHPWVNLSDHIVVKHVQTNHRCCSSLSEIELSSDNEVKQTNTLYFVGGNGEKSNKVVAVQPMSQFVDVTFHIHYVTQSLYQKVAITGNQQELGNWKGFVPLEKTKDGHWATVVSLPAESHVEWKFVVVDKGEVCRWEECGNRLLETGSGDDLLIQKWWGFL
The following text describes a protein:
Function:
Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
Sequence:
MLPTAVLLVLAVSVAARDNATCDGPCGLRFRQKLESGMRVVGGMSAEPGAWPWMVSLQIFMYHNNRRYHTCGGILLNSHWVLTAAHCFKNKKKVTDWRLIFGANEVVWGSNKPVKPPLQERFVEEIIIHEKYVSGLEINDIALIKITPPVPCGPFIGPGCLPQFKAGPPRAPQTCWVTGWGYLKEKGPRTSPTLQEARVALIDLELCNSTRWYNGRIRSTNVCAGYPRGKIDTCQGDSGGPLMCRDRAENTFVVVGITSWGVGCARAKRPGVYTSTWPYLNWIASKIGSNALQMVQLGTPPRPSTPAPPVRPPSVQTPVRPPWYFQRPPGPSQQPGSRPRPPAPPLPRPPRPPTPTASTTPTPPPQQVSAKPPQALSFAKRLQQLIEALKGTAFSSGRSYYETETTDLQELPAS
The following text describes a protein:
Function:
Methyltransferase that methylates adenine residues in the ssDNA and dsDNA sequence 5'-GATC-3'. May prevent degradation of viral DNA by the host restriction-modification antiviral defense system (Probable).
Sequence:
MMTKSNTKKSDKDLWATPWWVFHYAEQYFNIKFDLDTCAMEHNTKVKNFITPEQNTLTADWQGRYCWMNPPYSNPLPFVLRAISQSVLHNKTVVMLLNVDGSTKWFDMCVRNAKEIVYITNSRIPFINNETGEETDQNNKPQMLVLFEPKAPYGSLKSSYVSLHEMKEKGMLQ
The following text describes a protein:
Function:
This necrosis-inducing peptide induces a hypersensitive response on Cf-4 tomato genotypes. Race-specific elicitors are compounds which only induce defense responses in genotypes of host plants which are resistant to the pathogenic race that produces the elicitor, but not in susceptible genotypes.
Sequence:
MHYTTLLLSTLLVGTALAQPTNPPAKTPKKAPKTQPYNPCKPQEVIDTKCMGPKDCLYPNPDSCTTYIQCVPLDEVGNAKPVVKPCPKGLQWNDNVGKKWCDYPNLSTCPVKTPQPKPKKGGVGGKKASVGHPGY
The following text describes a protein:
Function:
Functions redundantly with BicD. Involved in formation and/or development of mechanosensory organs during metamorphosis. During macrochaetae development, together with BicD, involved in Rab 6 and Spn-F stability and distribution and actin cytoskeleton organization.
Sequence:
MHKPKLANAITAAAIASSISTKNNNNNSIVGGSSSSSSGGNKSKRPRQFGQYSIGVGTGAGAGGLLRSDDSGFDHLDYSSLIGDSIDLEHYISAMEARRHDQEPDVWAQLQQKESDILLAAELGKALLEKNEELVKQQEKLIEDYSSKIEKLEQEKHVLRQKLAIAEDESDQRVLELQSDLTELKDKLQTQDTAIRQAEKEKTILIDELQHQNTRLTEQIQEAHATELKLSAQIQELKDQYHYRNSSLQEHVNSLESIKTELNLTTGKRQELERRLQIAQEEKESLTSSLEESSDRIHMLERHAREQETKLETTLQALERSQRENNVLSERLGADTNSSTPGRKSLQFEMECDEDDGSYTETGKPNQMFVEARSVYIQLKSLVDSLKVSHDDDSGLNSDISLELESMDNTISSSERHEDGHLAIEFRQGMLSSMSDELTRLLLNLDAGNFKKMLDQTRNLVLEQEDEIKRSHQLIQQLEAKVTVTDVELQNVKEERDQARGDLEDNTDRDELLSKAQTERDAANDRRTKAEVELAKTRVELMQANSQLLESIQQKVELSQQLEQWQMDMHELIDEQMRSKLINNRRAMAAESSAPSPPSSAAANLAKRVTSYKLWSLFQR
The following text describes a protein:
Function:
Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.
Subcellular Localization:
Chromosome.
Sequence:
MLRPEISSTSPSAPAVSPSSGETRSPQGPRYNFGLQETPQSRPSVQVVSASTCPGTSGAAGDRSSSSSSLPCPAPNSRPAQGSYFGNKRAYAENTVASNFTFGASSSSARDTNYPQTLKTPLSTGNPQRSGYKSWTPQVGYSASSSSAISAHSPSVIVAVVEGRGLARGEIGMASIDLKNPQIILSQFADNTTYAKVITKLKILSPLEIIMSNTACAVGNSTKLFTLITENFKNVNFTTIQRKYFNETKGLEYIEQLCIAEFSTVLMEVQSKYYCLAAVAALLKYVEFIQNSVYAPKSLKICFQGSEQTAMIDSSSAQNLELLINNQDYRNNHTLFGVLNYTKTPGGSRRLRSNILEPLVDIETINMRLDCVQELLQDEELFFGLQSVISRFLDTEQLLSVLVQIPKQDTVNAAESKITNLIYLKHTLELVDPLKIAMKNCNTPLLRAYYGSLEDKRFGIILEKIKTVINDDARYMKGCLNMRTQKCYAVRSNINEFLDIARRTYTEIVDDIAGMISQLGEKYSLPLRTSFSSARGFFIQMTTDCIALPSDQLPSEFIKISKVKNSYSFTSADLIKMNERCQESLREIYHMTYMIVCKLLSEIYEHIHCLYKLSDTVSMLDMLLSFAHACTLSDYVRPEFTDTLAIKQGWHPILEKISAEKPIANNTYVTEGSNFLIITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYSSFRIAKQIFTRISTDDDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGICYAVCEYLLSLKAFTLFATHFLELCHIDALYPNVENMHFEVQHVKNTSRNKEAILYTYKLSKGLTEEKNYGLKAAEVSSLPPSIVLDAKEITTQITRQILQNQRSTPEMERQRAVYHLATRLVQTARNSQLDPDSLRIYLSNLKKKYKEDFPRTEQVPEKTEE
The following text describes a protein:
Function:
Catalyzes the hydroxylation of 3-hydroxyphenylacetate and 3,4-dihydroxyphenylacetate to 2,5-dihydroxyphenylacetate (homogentisate) and 2,4,5-trihydroxyphenylacetate, respectively. Both of these compounds are used as substrate by homogentisate dioxygenase in the homogentisate pathway. The homogentisate pathway is used to catabolize phenylacetate and use it as a carbon source. Can also catalyze the hydroxylation of phenylacetate to 2-hydroxyphenylacetate at low efficiency to compensate for loss of phacA.
Sequence:
MAIAEALLFVNNRAVEHPLQFLTAVAFAVPLLYVVINEFIRASARIPGFKGPRGLPLIGNLAQIRKDAAEQYRIWSKIYGPVYQIQLGNIPVLVVNSAAAAKVLFGQNAQALSSRPEFYTFHKIVSNTAGTTIGTSPYSESLKRRRKGAASALNRPSVESYVHHLDVESKAFVAELFKYGNGGKTPVDPMAMIQRLSLSLALTLNWGVRVASQEEELFDEITEVEDKISKFRSTTGNLQDYIPILRLNPFSSNSHKAKEMRDRRDKYLSSLNRDLDDRMEKGTHKPCIQANVILDKEAKLNSEELTSISLTMLSGGLDTVTTLVAWSISLLAQRPDIQDKAAKAIQEMYSEGQPLCDPADDQKCAYVAALVRECLRYYTVLRLALPRTSIRDITYDGKVIPKGTVFFLNAWACNMDPEVWSDPDEFRPERWFEQPDAPMFTYGMGYRMCAGSLLANRELYLVFIRTLNSFRIEPTEEKIEWHPLKGNSDPTSLVAIPKKYKVRFVPKNEVSLVEALS
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSADQQPLDQPIHQAIIDLAQELEQKPWILASGGDESVAEKSLSAAKAIFDLGVSLEPISHPHLHPFLLSVLEPPSINLRSRSKSEQDEPETQEAPTPESVLPYTPLSVLTVDGFDPEQVWAQLELRAHGIVNAVKSIDDSNGDAEEDFEGNPGSDDSDEDMTLEEFREMLKEAGYDNVDSMPDEELIEMRNEMEGGEDAMSLEEFREMLKESGEDVDDMTEEELMERMDEFEGDESDDSEESGSGSDEDEDDDDEEGDEDELLASASEGENDEEVSVGDDEDEDEEDEDEDEEDEEEEEEIQVEDQGNSEDDDTSALFGSTAGPSKPRKGHHPTLDDDFFSIDEFNRLTEEAEAGRLTSGRLGGDEDDEEELGDVGALMLDGAGDDEEIGYADFFEPPRGAKQTKGKSNGKEKKGKGKSKSKVRFDDDEVMDEDEEMAHEEVEDDDEARGIMGRVKGDLFDSDDEEDREDQVLSTHEKRQKALAEEIAQLESEAVGPKEWTLLGEASSRTRPQNSLLEEDLDFEHVAKVVPVITEDSVATMEELIKQRILDNNFDSPVRVRAFEPTPFLPSRFFELQDTQSSKSLAQIYEEEYQAAASGEKVKDARDQKLQKAHEEIEGLWGEICYKLDALSSLNFVPKAPKASITTISDLPTTSMESALPPTAAASTMLAPQELFAAPSSTDLVARSELTSEEAQKLRNKHRKHKKAERKKLGEMEELYGKKRKSAREEKEEALKGLVKSGKGVTVIGKGAKEMEKGKKRGTEGEEQDGKRLKL
The following text describes a protein:
Function:
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEPNEVIEEFETYLDLEGKSPHTIRMYTYYVRRYLEWGGDLNAHSALRFLAHLRKNGYSNRSLNLVVQALRAYFRFEGLDDEAERLKPPKVPRSLPKALTREEVKRLLSVIPPTRKRDRLIVLLLYGAGLRVSELCNLKKDDVDLDRGLIVVRGGKGAKDRVVPIPKYLADEIRAYLESRSDESEYLLVEDRRRRKDKLSTRNVWYLLKRYGQKAGVEVTPHKLRHSFATHLLEEGVDIRAIQELLGHSNLSTTQIYTKVTVEHLRKAQEKAKLIEKLMGE
The following text describes a protein:
Function:
E2-like enzyme which specifically catalyzes the second step in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage. Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy).
Sequence:
MADEATRRLVAELPLLKTNAGPRDQELWVKRLKEEYQALIKYVENNKNADNDWFRLESNKEGPRWFGKCWYIHNLLKYEFAVEFDIPVTYPATAPEIAIPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEIPDLISKGQIEHKEKGGA
The following text describes a protein:
Function:
May be involved in the septin organization at the site of septation.
Subcellular Localization:
Cell septum. Note=Localizes to two distinct rings on septal sites.
Sequence:
MDEQSSGQDVDQSLDTLLKEIDLKMQLRDGEEGRRASAQSEGSLRLPAVRMLERGMVASASHKSVTFDEEPPSVHEYSVVMDSSAGTSECAEEEREGADGYECAADTMRVLYDEDTDSSCMGSERALAGPAAEGIVPEGYKEADLLGTERAGSGTPSLSYDDAAGLGSPPHVIFTIKPTSPLNAYDRGSWEPLQSNTAMDTPPRGGTAVSQHGLFAKAPKLPAIPSPNSRRRVSYAGSDSYPSDDSATDKRSLTDKTVPDNRGENERGGFGYENSDRNPSIETGTTDEYQSAGEYKSMSSSEANDDSKTEASVEDLRISNKPQRDTTIQDLHATTLPRSSSTLIPPALPPLDPSFFGRLARSPSYSPIRDRGSSEGSVGEHDSSLEQDHELGMGQQSARTNSSASGNSSDSVMVKPLSLFSNSQVDSLHLGAPAPDNSTPNKEALPSACPPDAMKSIGTQTSILEDKAESGPSQSSATSEKSVMLPNFPRFESFFDDSYPFGHDSDRSNNSVSYSKRTLKPSNYLSIWHLQEAQMRHDSPAFSANSQFSCKMVGESKRTSLESSRLSAKYESRFKFKFKPKLVSRRRIYYNKDQWRNFQEPPTRYYSNCTESDHISSDVPGTPVSPSIKSRNLCHGRTRGNMKMVERVNSLCSANERLSSAGNGDETFLSASSNLDVTSRRPSVDIISEISTKDLLPKIKQDSDGFNELIKTFVDHDEQSQQTDSTIASYRRGTRDTTIYHIWEHSIQENSISDYGNSPTAGKGTISKLLDNHEVEFDGKNSFVTGLGIIKKTDQDSRVDVLRIDSTQGIEAIQSFSPYSYRNAFDPVTPTKSAYHGCEALQASQMGTPFRPAISTTLQAQSGLGHKRPAVERPTTAQLGNYVSAEMSPEVQEPAEETKKRTDLQDNGQLYFVFVGIEQLALRDIERHSAECSIEFDNGNNVVQSEWLPLPKSGSMSLNQEYSVIIAEESLPNMIITLKCRYKSPKKELVEITEKVPLKSKCCGLGKPKYKQVKKLLRREMDFDEWDYKIAQDGSFARCKEQIDEELLKNVRYKKQQFRWTLLSEWERDHSKEHKRKRAWELPRLPAHPAGALVVDMCYLPRTSRFEKFPKTLQIARRVVNKFKEQKAIAMEGFMWQEGGDTEVLKRRYFTLNGTQLVAHHEITKKPKAMINLLRVEKLLTEAEISREMLSSSSRCFTDLVLLHECFVLFFENGEEIMFNPDTKTEKLEWIEKLRKVIELNRFHQPWVKKFLNSSENIL
The following text describes a protein:
Function:
Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Sequence:
MNETDIKFLESAFKKYYFEQFELIRVPERTSEREFGYQKFNSGMTRHISVKDDKELHLLLMQNVPSDVYCSNAYYSFPNLPMNEKDWKEADLIFDIDAKDLNLSCRGNHTLSICNECHEISNNSEKCSKCNSTKLEKKSLPCKNCIDSSKIEVKKLSEILTNDLSVNKDDIQVYFSGNEGFHIYVYNSQFQQNGSRERSELVDYIMFNGAIPEKFGMKKFKPNRNSFPDFDEAGWKGRFSKYVYGSKSKRSKIVSELLSNGYSSFQKTLDDVSENIGTKIDPNVTMDIHRIFRLPGSINSKSGLTKIHCKDLVKFDAYVDSSFLSDDSVEVLANCPIEFKLKNKKFGPYHNEKVSVPTFAAVYMVCKKLATIA
The following text describes a protein:
Function:
Component of the PhsABC thiosulfate reductase that catalyzes the reduction of thiosulfate to sulfite and hydrogen sulfide, with menaquinol as the sole electron donor. Proton motive force (PMF) is required to drive transmembrane electron transfer within the reductase. The PhsB subunit transfers electrons between PhsC and PhsA.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Periplasmic side.
Sequence:
MSCTRRQFITRVGALAAVSGMAGRVVANTLNINGVRYGMVHDESLCIGCTACMDACREVNTVPEGVSRLTIIRSEPQGTFPDVKYRFFRHSCQHCDHAPCVDVCPTGASFRDAASGIVDVNPDLCVGCQYCIAACPYRVRFIHPVSKTADKCDFCRKTNLKAGKQPACVESCPTKALTFGNLDDPNSDISRLLRQKTTYRYKLALGTKPKVYRVPFNYGEVSQ
The following text describes a protein:
Function:
Receptor for ecdysone. May be an important modulator of insect metamorphosis. Plays an important part in embryonic and post-embryonic development. Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene.
Subcellular Localization:
Nucleus.
Domain:
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Sequence:
MDNCDQDASFRLSHIKEEVKPDISQLNDSNNSSFSPKAESPVPFMQAMSMVHVLPGSNSASSNNNSAGDAQMAQAPNSAGGSAAAAVQQQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQRGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSIERIIEAEQRAETQCGDRALTFLRVGPYSTVQPDYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVSAIFDRILSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFLFRITSDRPLEELFLEQLEAPPPPGLAMKLE
The following text describes a protein:
Function:
Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions.
Subcellular Localization:
Nucleus.
Sequence:
MTMTTMPESLNSPVSGKAVFMEFGPPSQQMSPSPMSHGHYSMHCLHSAGHSQPDSSYSTASSFSRPLGYPYVNSVSSHSSNPYISSVQSYPNSSSLTQTRLEETGADSEKSTVVEGGEVRFNGKGKKIRKPRTIYSSLQLQALNRRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLMKQGGAALESSALANGRALSASSPPVPPGWNTTSSSGKSSTGNAGTYIPSYTSWYPSAHQEAMQQPQLM
The following text describes a protein:
Function:
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSNNSRLPENGVQSGNGEDAELKKSMRIIEREIPDSLLEKIPEAEDYIALQDLERKLDSLIVRKRFDLQDSLSRNSHKTRILRMYIHSTVANQSWQQKGENQENNSGDINSLPIPEWTLHIEGRLLVNPDDEDDKAFELAPFTNFFRKIAIQILRSDDLYPSGNYVEWNKLPDNSNTSNGITVTRKGDQSVDVKIMLYPEEHPERYKLSKAFANILGIREGTRPDIVSYLWQYIKFHRLQDMEEKRLINCDKALRDLFEADRLYFPRIPELMNRFLEPIDPIVIPYTINVSEHTVEKVTIFDIRINTEDPRHSQIRSFLATMMSQDKIRSIDDKLTELIQAITYSQSKYDFMKKFSESPIEFINEWIESQSRDLEIVLDGTNMNYAEKRSADYYQQPWVHESAFHYLNLLNSKKQQSVLNASAKK
The following text describes a protein:
Function:
The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation. May play a role in the regulation of proline metabolism and ROS production.
Miscellaneous:
MISCELLANEOUS: Amplified and overexpressed in oral cancer cells.
Subcellular Localization:
Nucleus.
Sequence:
MAGSQDIFDAIVMADERFHGEGYREGYEEGSSLGVMEGRQHGTLHGAKIGSEIGCYQGFAFAWKCLLHSCTTEKDSRKMKVLESLIGMIQKFPYDDPTYDKLHEDLDKIRGKFKQFCSLLNVQPDFKISAEGSGLSF