lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MKLKEVNRTAIQSWSPAQHHPIYLATGTSAQQLDASFSTNASLEFFELDLADPTLDMKSCGSFSSAHRYYKLVWGPFGMDSQNHPAGVLIAGGENGNVILYDPARIMAGKSDVVITESDRHSGPVRALDVNPFQANLVASGGNESEIFIWDMNNFGSPMTPGPKTQPLEDISCVAWNRQVQHILASASPSGRASVWDLRKNDLIIKVSDHSNRMHCSSLAWNPEVATQLVLASEDDRMPVIQMWDLRFATSPLKILEHHTRGILAISWSLADPELLLSCGKDSRILCWNPNTAEVLYELPTSSQWCFDIQWCPRNPAVLSAAGCDGHIDIFSIMGGSNQAQSQRHADQISNSFGNMDPFGTGQTLPPLQLPQTSAPPASVIPLRKPPKWICRPVGASFAFGGKLVSLDNAKPQQQQPSSHLVHISQVVTETALLDRSEQLQATLSSRNFVGFCQEKIDAAENEFEKTLWSFLKVNFESDVRSKYLELLGYNREELASKISAALAEKPADLPQPDPSVPAPLQPPADLPPADAPEAAFDWIAAANSQPAVTLSPTPESEEPEEPAEDGQEANLDQVLQEDEEAEEKEEEEEIPLNEDVAAPAEEISPAETPAAVPAPTPAGVALSISQDVDGLITQALLTGDFEAAVELCLHDNRMADSIILAIAGGAELLETTQRKYFTKTRSRITKLISAVVTKDWHDILRTCDLQNWKEALAAVMTYARPEEFSSLCDLLGGRLEAAEDAQLKSQACLCYICAGNVEKLVSCGTRAQAGHSPLSLQDLVEKVVVLRQAVEQTQRSGPAAIGVLLAEKMSLYANLLAAQGSLATAITYLPDDTNQVSVQQLRNRLSRALGHQVAAPPTHPQGVPSHHPQPGSAPFVPAQQPAAPPAQQHYRQPVRAASTVTSWSNQTPTALPNVPPLPHPHPVGSASNPQAEPPAPGYRMLTPASAAPPPASSAPAYAFSHQYQPFPQVNRYPSQAGGQPAYPPQYSSAAPPQTPPTDPSSPPPHPPGFLPQYTQPVPPQPAPLRYPGQPPSSHPDFFPSSSSASSSSSSSFSALPSFGESFQHGGPGSPVSYLPPPLTGVSGPQNGWNDPPSLTHASKKKQLPENYTPPAPITAPIMAPLGTDPMAQQIPPAAPQGPQVPFSGMHQQQLTPPSVNPAMPNTSMEGAPGAPTGDMIQPLQSIPAEKILKKPIPEEHLILKTTFESLIQKCLAVAADPQTKRKLDEASKRLEALYDKLREQTLSPPIITGLHNITRSIEARSYTESLNIHTHIVSHSNFSETSAFMPVLKVVLTQANKLGV
The following text describes a protein:
Function:
Binds both saxitoxin and tetradotoxin. May play a role in toxin accumulation and/or excretion.
Subcellular Localization:
Secreted.
Sequence:
MGAVPGVVLLLMLAVLGIRAAPAPEECHKLTKPVTKADVQSVSGDWVLVWSVANTTERWICENLTSSYVEFKLHSDIIEYTERNLFLGNSCISFYSNLSASTEKQQQFSLNNLQMEEKGVVRPFNDNGTVKFFETCVDCLSMEYSGDIGRFLLIYRRDGVHQNVEVLKAAQDESQKLAECLGFSIDEPFIYDGVSDFCHKKSPEECHKLTKPVTKADVQSVSGDWVLVWSIDENSTISDDWKKLKTSYVEQRVDSGVIRFTERNMLKNNSCMTFKTNMTAGPESQNTFIYTSGKMEENGVVTVLDENGTVKFFETCADCLSMEYSGFFGHFLLIYRRDGVHQNVEVLKAAQDESQKLAECLGFSIDEPFIYDGVSDFCHKKSSPEVKPEQD
The following text describes a protein:
Function:
Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
Sequence:
MAKQVLTYIDAKEFAYIIDSISVLVEEANFLIRNDGLYLRALDVSRTAMVDLAIPKESFEEFPEVEELRFGLNFKELKKLLRRVKKGDKISMEFEEGRVRIKLIGKSVRSIVVPSIEVVGEELPTPKVVYTAMVKAASDVLATAVKDADAVADEVKFEASEEALIISASSDKGEVEVKLDKNSELVYEFDVKEPASARFSLEYLVDITSKTSKISDIVTIELATAKPIYLSFDIPAGGKISYFIAPRVE
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
MADEQESQPTRITCGFYVKRKNRYCKMIVGKGKKYCGEHMHLSGENGDNRKRILCPLDPKHSVYEDQLKNHLKRCNVKKKTDVVYYAKNINSGIVDYKPSSEEKIPLSSFPQDCISKVIHKLKKFFKDNNLEVMPHIMSHDAFKAEMSQENYGPSVHKHLKQQASLVGNMERLGLLQPDTVYLEFGAGKGKLSHWVQQAHPEGGNVEYVLIDRASNRYKFDSCHKRGDNGPDFKRVLLDIEHLNLGELPHLGDKTRRIVAVSKHLCGTATGRYLTLRCLLDTLHGSSATEPDSTLKSEQKDAKRRKLDAAGPSVIGIVVALCCHHQCYWPHYVGRPFLESLGITPQEFHLLCCMSSWATCGMRPPQGSSKEAEHCNTDESGETDDDNGVDGSDKGLGLSIADREEIGRQCKRLLDAGRVWYLREKGFNTSLAYYVDSSVSLENVVLLATANT
The following text describes a protein:
Function:
RNA-binding protein.
Sequence:
MNGAGGNHQQQQQQQQRLRQQQQQQALLMQQALQQQQQYQSGVLAAAAAAAMTQMEPISNGNLPPGFDPSTCRSVYVGNVHPNVTESLLIEVFQSSGLVERCKLIRKEKSSFGFVDYYDRRSAALAIMTLHGRHICGQAIKVNWAYASTQREDTSGHFHIFVGDLSSEVNDATLYACFSAYPSCSDARVMWDNKTGRSRGYGFVSFRNQQEAETAITEMTGKWLGSRQIRCNWATKNNAEEKQETDNHNAVVLTNGSSSNPGMEASQDTGSKENPENNPDCTTVYVGNLGHEVNRDELHRHFYNLGVGAIEEVRVQQDKGFGFVRYSNHGEAALAIQMANGLVVRGKPIKCSWGNKPTPPGTSSKPLPPPLPSYQPVPMAGVPQGFSAADIVAYQRQLTLSQVAAGQIAGQHGLAGQVSAGLLAAGSQALYDGYPNQSSAQQLMYYN
The following text describes a protein:
Function:
MRS3 suppresses a mitochondrial splice defect in the first intron of the COB gene. It may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations).
Miscellaneous:
MISCELLANEOUS: Present with 1360 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MVENSSSNNSTRPIPAIPMDLPDYEALPTHAPLYHQLIAGAFAGIMEHSVMFPIDALKTRIQSANAKSLSAKNMLSQISHISTSEGTLALWKGVQSVILGAGPAHAVYFGTYEFCKKNLIDSSDTQTHHPFKTAISGACATTASDALMNPFDTIKQRIQLNTSASVWQTTKQIYQSEGLAAFYYSYPTTLVMNIPFAAFNFVIYESSTKFLNPSNEYNPLIHCLCGSISGSTCAAITTPLDCIKTVLQIRGSQTVSLEIMRKADTFSKAASAIYQVYGWKGFWRGWKPRIVANMPATAISWTAYECAKHFLMTY
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEHATSELREFISDLVIPHQRCNVNINPDHITMLEGTKIKKQHSRKRRAHKSSTLSRREYAALGLNTLPTKQMKYEEALPLHHLWKGYVREHLELREGDEVPQVHDARYDEFSRKLVKLDLHGAKMKVLQSKCSTLENLAGICVMDTKNVLKLLGKDHRLRTIPKSECVFGMKVGNMEFTIFGQHLNIRPAERSVKKIKNFVKPFM
The following text describes a protein:
Function:
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
Sequence:
MGAVSRDDYIALCTELVEHDRRYYVLNQPTISDYSYDVKMRELQEIEVQHPEWKVSWSPTMYLGDRPSGQFPVVPHSSPMLSIANVYSLQELEEFFSRTEKLLGYSPGYSLELKIDGIAVAIRYEKRLFAQALSRGNGVKGEDITANVSTIRSLPMRLPQEAPEDLEVRGEVFLSYEAFEELNACQREQGKLEFANPRNAAGGTLKLLSSKEAAKRKLDLSVYGLITDQKKRSHFENLQLCSQWGFFVAGMPKQCRSRQDVVERIREIEEMRAALPMAIDGVVIKVDNIAYQDRLGLTSKHYRWAIAYKYAPERAETILEDIVVQVGKTGILTPVAELAPVFLSGSRVSRASLYNQDEIEKKDIRIGDSVYVEKGGEVIPKIVGINLAKRSLESEPWKMPSLCPVCHEPVVKEKVSVRCVNPLCSGGMLEKICFFASKSALNIDHLGEKVVTKLFEVGLISSCSDIFALAEEDLKQVPGFKDRSIQNLLASIAGAKKVALDRLLTALSIPFVGSSGAIALADHFGTLDKVIEASLDELMSIEGIGPKVAASIVAFFSKHENREEIRRMQELGVQVLSKQSDKEAPLQGKVFVLTGTLQQMTRTQAEERIRCLGGKVSSSVSKSTYAVIAGSEAGGKLKKAQDLGLSIWNESELLRILDAKSVS
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Sequence:
MTALTGRIRRPNAFAYAKSKQKEVCLRVCFPVFHALLQTLFLLSLLPTGRLASSLLPRPSAIYRTLAYRTPLDMINQQPYPPPYPQVNNYPPPGPPQGANYPPPQGANYPPPPYSPGPNYPPPAPITQQPGTPGFGNNIDVCKTLIDHFEEEIRYKILNGAGQQIYAANEESDCIERFFCHHKRGFVIHEIILIKKNFHICTALNAPLHMIQIYCHICSFCQQQATIESPPGNIVATVRQTWRPTHTVRGPDGQIIFTLNAPSLKMVCCCREQIYEVYAGKDKVVGISKFWGGALKEFFTTADIWGITFPPQMPVHHRAIVLGSLFFIDFVSFEGQGCTVQGWLPKLAKCGIF
The following text describes a protein:
Function:
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPFVQRVVEPKFLSRTSLWDEEGKPLVSDDELEAVTNNTLSNALRQLASLVLIADDIFAELGSQLKEINKRSEGLKAKIAAVEGKVSAFDPKKVTVPESDICTFALLKNHYAAKCNPETGLFTASTRPRALQSLYEAATKTPVHLMRQLDRWRRDGHRSSRFFLCTPVLGNKRRKIRNKVDIDIETRMPAAVQELRRWTSSEALGDITVTPDCPNRIAPNFTLTDGEATDGTAVSDDEGIDHKLPSPEEQLQVVALKFPAEIVAVDVSGRSFDRMSIQRRSLLHTDANAAKAEDPSLKRRTRTRRPRTRRRNTLAGTDQKEIRDALTAGEEPCSSANNHETESTTIGAVSRSKSSDLLRSSNKKDSPDKKSHFNTLKQWGKNRYDRFMNKSSESKSEKKDDIDDFNIYETVTMKRKRNVDKDRRSHERNPSISSSEKSSVNLPVSSPLSSVMNIAVKLRESSAQRRQRRSGGSNKDEPPHSSSGNWSASSESGRASIGSEFTSTTQPKSTTSAATSNNSLNQQAPNSANSRRRFVANTSTSSSITSEGTLTPDIIHDLHEDGETSSVYSCDTEGYYTSFHMDSGLKTLKEEDLPCTPLHSTSAFSSSSNNTMTAENEYELFGKGSTSTTTSSAGTVCTTLRASESNRSLNGCPAVPERKSSLSKHSNKDNSPESSLERDETSEKTGTVKRSPATNKASVVAMVHKQVNGDVSPDSGHNTSSSPIESISSPNGVRSGSEFEFSESSDMEGPERIERIRIKTTINSSRIPSMCVITPPHSDDESIKSYNLNNFNKRNLIDRRNADRNKLDLNLKTSENEVNLLKSSDSDKENFTIQSRIINGTNKMQVINVNPQSGYATVEVVDANENIDVNKSSKVLRAPSPSGGTVTINETPGKSPPTQPIIKATLLPFNNMFGRIKTNLANLTRRDSKSPNRNNQAISEEMGDSGEYVTLADVKNNNEKILTPKTETLYANDIVRKNLKFSGEKKRDTEYVSLDELPRNEDQTAASADNTNDSLERKRRQGARVTLDAEGKVVYSSDSLRRRKGAHTTFEPGPFVKTTASPSQSPLPVHRLPKSVRPPQDSSRPLSPQLGKLVIRAVPGMTSPTTEFIRIPPSTIVAPSVRPTSPKAARGAYVHMQDTGKPAQDKGKPPLPAQTAPHAQISHDTVNRMNVINCSRKIVKRSDSYRIANTILSPAKMLSDKIDIEDRIEKEIAAELWRERINYPPTVSPKCGRHIYTRVQAQEILLASPNRVIIPPDSGEHRARVLTASVADTEIW
The following text describes a protein:
Function:
Part of the ABC transporter complex TcyJLN involved in L-cystine import. This high affinity cystine transporter is involved in resistance to oxidative stress by forming a L-cysteine/L-cystine shuttle system with the EamA transporter, which exports L-cysteine as reducing equivalents to the periplasm to prevent the cells from oxidative stress. Exported L-cysteine can reduce the periplasmic hydrogen peroxide to water, and then generated L-cystine is imported back into the cytoplasm via the TcyJLN complex. Functions at low cystine concentrations. The system can also transport L-cysteine, diaminopimelic acid (DAP), djenkolate, lanthionine, D-cystine, homocystine, and it mediates accumulation of the toxic compounds L-selenaproline (SCA) and L-selenocystine (SeCys). Binds cystine and DAP.
Subcellular Localization:
Periplasm.
Sequence:
MKLAHLGRQALMGVMAVALVAGMSVKSFADEGLLNKVKERGTLLVGLEGTYPPFSFQGDDGKLTGFEVEFAQQLAKHLGVEASLKPTKWDGMLASLDSKRIDVVINQVTISDERKKKYDFSTPYTISGIQALVKKGNEGTIKTADDLKGKKVGVGLGTNYEEWLRQNVQGVDVRTYDDDPTKYQDLRVGRIDAILVDRLAALDLVKKTNDTLAVTGEAFSRQESGVALRKGNEDLLKAVNDAIAEMQKDGTLQALSEKWFGADVTK
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MNTNYIVYQQWQERLERQPNCLEKLCSCNYFFRKKTHKTNEKYQLKESIPQNYIKICVLYLDETLVHCQYKPDNSYDFHLIVKFIVQSICDNQTWGRNFIQTLSEYYEVIMWTASLKEYADPIMNIIDG
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
ILELLIQRDKEFQELMKLALDQGKIHHEMQLLEKVVEKRDNDIQQLQKQLKEAEHILATAVYQAKEKLKSVEKARKGAVSSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSANGVNGHLPGDALAAGRLPDVLAPQYPWQSSDMSMNMLPPNHSNDFMLEPPGHNKENEDDVEVMSTDSSSSSSDSD
The following text describes a protein:
Function:
Xyloglucan acetyltransferase that catalyzes the acetylation of fucosylated Gal residues on xyloglucan side chains. Predominantly catalyze 6-O-monoacetylation of Gal residues in the Fuc-Gal-Xyl trisaccharide side chains of xyloglucan oligomers.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MGSPFKDHHTLHPSLVRKLIPWTFYAMVPLVLFRVYLYPYPLHHTTTTILTSSPVSPPPALLEDETSCDYTDGNWVPDRRDPLYNGSTCGTIKEGQSCIAHGRPDMGYLYWRWKPKQCKLPRFEPNTFLQLLRNKHLAFVGDSMARNQLESLLCMLSSVSPPNLVYRDGEENKFRRWYFESHNFSISVYWSPFLVRGVEKSNTGLNHNQLFLDHVDERWAADMNGIDMVVLSIGHWFLHPAVYYEGDQVLGCHYCPDLNHTEIGFYDILRKAIKTTLKALVDRKGPNDNGFDALVTTFSPAHFEGDWDKLGACPKTEPCKEGEKTLEGMDAEMRQVEVEEVEAAKMNSVQLEKFRLEALDVSKLSLMRPDGHPGPYMHPFPFAYGVAERVQNDCVHWCLPGPIDTWNEILLEVIKKWEYASRREQ
The following text describes a protein:
Function:
Kinase involved in the biosynthesis of the core oligosaccharide region of lipopolysaccharide (LPS). Catalyzes the phosphorylation of heptose I (HepI), the first heptose added to the Kdo2-lipid A module. Also has protein-tyrosine kinase activity: autophosphorylates on all Tyr residues; in vitro can phosphorylate poly(Glu,Tyr).
Subcellular Localization:
Cytoplasm.
Domain:
Shares similarity with eukaryotic protein kinases in the conserved tyrosine kinase functional motifs.
Sequence:
MRLVLEEPFKRLWNGRDPFEAVEALQGKVYRELEGRRTLRTEVDGRGYFVKIHRGIGWGEIAKNLLTAKLPVLGARQEWQAIRRLHEAGVATMTAVAYGERGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHRAGVNHRDCYICHFLLHTDKPVSADDFRLSVIDLHRAQTRDATPKRWRNKDLAALYFSALDIGLTRRDKLRFLRTYFRRPLREILRDEAGLLAWMERKAEKLYERKQRYGDLL
The following text describes a protein:
Function:
Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
Sequence:
MQVLKRKVLALVGNHAVAYAVKQAKPKVLAVFPITPQTTMLEKLSEYISSEELKAELIKVESEHSALASIYGAALAGARVFTATSSQGLLYMTEMIYWAGGQRVPIVAAVATRAIAEPWSIWDDHQDFVSKRDAIWIQIMAENVQEAYDMTIQAFRISEDERVILPVMMGFDGFILTHTMERIEVLEDNEVDNFLPPRQFNLIDFSDPIAIGPIATPEEYIKYRYEAMKAMERAKGVIEEIMGEYERISGRKQHGLVECYKCEDAKYVFVTMGAWSGDGKAAVDRLRDSGVKTGLLKIRVFRPFPKEKVEEYLRSMKGVVVFDRAYSYGYGGILVNEIKAALYGYRVPVYSVVAGIGGKDVRPRHFQKVIEDLINDNLEEERWLF
The following text describes a protein:
Function:
Probably part of the binding-protein-dependent transport system YphDEF. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSASSLPLPQGKSVSLKQFVSRHINEIGLLVVIAILYLVFSLNAPGFISLNNQMNVLRDAATIGIAAWAMTLIIISGEIDVSVGPMVAFVSVCLAFLLQFEVPLAVACLLVLLLGALMGTLAGVLRGVFNVPSFVATLGLWSALRGMGLFMTNALPVPIDENEVLDWLGGQFLGVPVSALIMIVLFALFVFISRKTAFGRSVFAVGGNATAAQLCGINVRRVRILIFTLSGLLAAVTGILLAARLGSGNAGAANGLEFDVIAAVVVGGTALSGGRGSLFGTLLGVLVITLIGNGLVLLGINSFFQQVVRGVIIVVAVLANILLTQRSSKAKR
The following text describes a protein:
Function:
Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer two glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA). In vitro, UgtP can also use cholesterol, cholesterolglucoside and the fluorescent substrate 6-(N-7-nitrobenz-2-oxa-1,3-diazol-4-yl)-amino-caproyl-sphingosine (NBD-ceramide) as sugar acceptors, but it can only use UDP-glucose as sugar donor.
Subcellular Localization:
Cell membrane.
Sequence:
MVTQNKKILIITGSFGNGHMQVTQSIVNQLNDMNLDHLSVIEHDLFMEAHPILTSICKKWYINSFKYFRNMYKGFYYSRPDKLDKCFYKYYGLNKLINLLIKEKPDLILLTFPTPVMSVLTEQFNINIPVATVMTDYRLHKNWITPYSTRYYVATKETKQDFIDVGIDPSTVKVTGIPIDNKFETPINQKQWLIDNNLDPDKQTILMSAGAFGVSKGFDTMITDILAKSANAQVVMICGKSKELKRSLTAKFKSNENVLILGYTKHMNEWMASSQLMITKPGGITITEGFARCIPMIFLNPAPGQELENALYFEEKGFGKIADTPEEAIKIVASLTNGNEQLTNMISTMEQDKIKYATQTICRDLLDLIGHSSQPQEIYGKVPLYARFFVK
The following text describes a protein:
Function:
Nucleotide sugar antiporter transporting UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-glucose (UDP-Glc) from the cytosol into the lumen of the Golgi in exchange of UMP. By supplying UDP-N-acetylglucosamine, a donor substrate to heparan sulfate synthases, probably takes part in the synthesis of these glycoconjugates.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MAEVHRRQHARVKGEAPAKSSTHRHEEELGMASAETLTVFLKLLAAGFYGVSSFLIVVVNKSVLTNYRFPSSLCVGLGQMVATVAVLWVGKALRVVKFPDFDRNVPRKTFPLPLLYFGNQITGLFSTKKLNLPMFTVLRRFSILFTMFAEGVLLKKTFSWGIKMTVFAMIIGAFVAASSDLAFDLEGYVFILINDVLTAANGAYVKQKLDSKELGKYGLLYYNALFMILPTLAIAYFTGDAQKALDFEGWADTLFLLQFTLSCVMGFILMYATVLCTQYNSALTTTIVGCIKNILITYIGMVFGGDYIFTWTNFIGLNISIAGSLVYSYITFSEEQLSKQSEASSKLDIKGKGAV
The following text describes a protein:
Function:
Acts on leucine, isoleucine and valine.
Sequence:
MTQAIYINGEYFSREDAKISVYDHGLLYGDGVFEGMRIYSGKVFALEDHMTRLYESARAIMLDIPIAIDALTTAVNETVAKNGLTEGYIRLVVTRGGNQLGLNPFSCEDPQVIIIADTISLYPEKFYTEGLELITASTIRNHPAALSPRVKSLNYLNNIMAKIEAIRAGCIEAVMLNTKGEVAECTGDNIFIVRGGRLITPPIDAGILEGITRNTVIDLARENGIEVAEEAMTRHDIFVADECFLTGSAAEVIPAVKLDGRVIGDGKPGPMTQKLNAAFRAFVAR
The following text describes a protein:
Function:
Involved in ribosome biogenesis. Required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1) (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPKAKKRVSLASKASSRLPSSGKPSQQASIPNVELSSTVTSNSQVLNNDPLKETKKDKRKDRHFNWQQKFSNPKISASARKRRNRKARENLKVNVSSIGEVLPEIDLDISVANSRLKPVIKDSLSSKQTKSSMKRNTVEEIERFQAILKHPSFVSNPLETVREHLGNSLDSR
The following text describes a protein:
Function:
Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(3+) atoms. EntB is a bifunctional protein that serves as an isochorismate lyase and an aryl carrier protein (ArCP). Catalyzes the conversion of isochorismate to 2,3-dihydro-2,3-dihydroxybenzoate (2,3-diDHB), the precursor of 2,3-dihydroxybenzoate (DHB). In the enterobactin assembly, EntB functions as an aryl carrier protein phosphopantetheinylated near the C terminus by EntD to yield holo-EntB, which is then acylated by EntE with 2,3-dihydroxybenzoyl-AMP to form DHB-holo-EntB. Then this product will serve in the formation of the amide bond between 2,3-dihydroxybenzoate (DHB) and L-serine.
Subcellular Localization:
Cytoplasm.
Sequence:
MAIPKLQSYALPTALDIPTNKVNWAFEPERAALLIHDMQDYFVSFWGRNCPMMDQVIANIAALRQYCKEHHIPVYYTAQPKEQSDEDRALLNDMWGPGLTRSPEQQKVVEALTPDEADTVLVKWRYSAFHRSPLEQMLKDTGRNQLIITGVYAHIGCMTTATDAFMRDIKPFMVADALADFSREEHLMALNYVAGRSGRVVMTESLLPTPVPASKAALRALILPLLDETDEPLDDENLIDYGLDSVRMMGLAARWRKVHGDIDFVMLAKNPTIDAWWALLSRGVE
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAQTEVLVFGSAIIDFISYTTRLPKAGETLHGHRFQIGYGGKGANQCVAAARQGSRTALVAKLGADTFGSDYLRHLREERVNVNHVEQLAEETTGVAQIAVSDGGENNIIIVVGANNRLSSCDVSSAKALFQEAKVLVCQLETPVEATLTALRAFRGVSIVNAAPAMADTPPELLQLASIFCVNESEAALMTQMPDIGNIEHAEDAVGKLIAAGANTVIITLGKLGAVFGSADSKGVCQHVAAPSVPPEKVVDTTGAGDAFIGALAHNLARHPTRKLEEHIAAACAVASQSVQLPGTQSSFPHA
The following text describes a protein:
Function:
Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQIFVKTLTGKTITLDVEPSDTIDAVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLDVEPSDTIDAVKAKIQDKEGIPPDQQRLIFAEHSQIITIQRGINPSLGFKIKRRNTLTGKTITLDVEPSDTIDAVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLDVEPSDTIDAVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLDVEPSDTIDAVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGQ
The following text describes a protein:
Function:
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
Subcellular Localization:
Cytoplasm.
Sequence:
MRNDLETLKHIIDSSNRITFFTGAGVSVASGVPDFRSMGGLFDEISKDGLSPEYLLSRDYLEDDPEGFINFCHKRLLFVDTKPNIVHDWIAKLERNQQSLGVITQNIDGLHSDAGSQHVDELHGTLNRFYCNACHKSYTKSDVIDRTLKHCDNCGGAIRPDIVLYGEMLDQPTIIRALNKIEHADTLVVLGSSLVVQPAAGLISHFKGDNLIIINKDRTPYDSDATLVIHDDMVSVVKSLMTE
The following text describes a protein:
Function:
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.
Sequence:
MATQEQLELSGLIKSVHQRLRDSAKQQDPEAVWKEHVRDAGLLKSYAEAMHKLATCYWDRTMEVSCKRSNSRIEWVVASCRSYFHGATPLLYLFREKDDKVMQAIDGIGHQPAHRPYTIDRIRLLDVGSCYDPFACFPDFDVTAIDIAPACASVWHCDFLEAEILKSITEPLVSVEHHSIEAFPSEHYDAIVFSLLLEYLPSPDQRLQCCRKAYELLKPEGILLIITPDSRHQGANAKLMKNWRYTLGLMGFGRIKIEKLEHVTCMVYRKCIFPAVSKRWCDIHREAYMQPVLNIPQDFNESKVDGREQEDEMAVCRTEEDEGEIREAFAGLPFLDS
The following text describes a protein:
Function:
Involved in the biosynthesis of the disaccharide D-N-acetylglucosamine-L-rhamnose which plays an important role in the mycobacterial cell wall as a linker connecting arabinogalactan and peptidoglycan via a phosphodiester linkage. Catalyzes the transfer of the N-acetylglucosamine-1-phosphate (GlcNAc-1P) moiety from UDP-GlcNAc onto the carrier lipid decaprenyl phosphate (C50-P), yielding GlcNAc-pyrophosphoryl-decaprenyl (GlcNAc-PP-C50) (By similarity).
Miscellaneous:
MISCELLANEOUS: Mycobacteria use decaprenyl phosphate (C50-P) as a lipid carrier in all known cell wall biosynthetic pathways, rather than the usual undecaprenyl phosphate (C55-P) usually used in Gram-negative bacteria.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQYVREMSSDLATFASGLLALFERSAGVPLRELALVGLTAAIITYFATGLVGVLANRLEAVAYPRERDVHVTPTPRMGGLAMYLGVLAAVFLASQLPALTRGFVYSSGMPAVLVAGAVITGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIPLGGVGTIVLDQTSSILLTLALTVSIVNAINFVDGLDGLAAGLGLITAMAICIFSVGLLRDHDGDVLFYPPAVISVVLAGSCLGFLPHNFHRAKIFMGDSGSMLVGLMLAAASTTAAGPISQNAYGTRDVFALLSPFLLVVAVMFVPMLDLLLAIVRRIRAGRSAFSPDKMHLHHRLLQIGHSHRRVVLLIYLWVGIVAFGAASTIFFNPRNTGAVMLGAIVITGMATVIPLLRRRDNY
The following text describes a protein:
Function:
Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Sequence:
MLPRLLVSLAALLCLCPGPGAHGTELPSPSSVWFEAEFFSHILHWTPIPKPSNSTYYEVELLRYGLEPWKRIPSCNQTQVLFCDLTMVTLDLYHNNGYRAKVRAVDGNQSSNWTLTNTRFSMDEVNLTVGSVKLEVENGIILGKIQPPRPRIAPTGDTYESIFQHFREYKIEIRKVPGNYTFTKTVKHENFSLSPPGKLGNFCVKVKPSVSSRMNNGIWSKEECVVLTYQYFTVTNLSIFFTFVLLLCGALAYCLALHLYVWHRRKLPPVLIFKKPQPFSFISQLPYPEPQDTIHPLDEEAFPKVSSELKNLELHGSTDSGFGSAKPSLQNEEPQFLLPASHPQAEGTMGKGPSLEPGSSCSGGSSNSTDSGICLQDPSLSPSTGPSWEQGGEQPGDQDDSGIGLVPNSEGQPGHERSGSALDHIDPPGPEAPGEEDLTFRGYLKQTRCTEEKAAKADCLEEESFSPDSLSPKFRTCLEAGWPPPALAKGYLKQDPGMTVTPSGTSTGQWNQPTKEWSLLGLTSCGDLRASDWSLAHDLAPLDWVAGPMGLLGKFDSNLATLPLISSLHSSE