lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in endocytosis.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle membrane.
Sequence:
MADAEYESVLCVKPEVHVYRIPPRSSNRGYRAADWQLDQPAWTGRLRITSRGKMAYIKLEDRTSGELFAQSPVEQFPGIAVESVIDSSRYFVICIEDGNGRRAFIGVGFADRGDAFDFNVALQDHFKWVKQQAELAKQAQNPDPGPKLDLGFKEGQTIKINIANMKKKEGTVGSTKPRPLSGTLNLLPPPPGAKLPAPSASPAQPFPAQPCPAQPTAAASTAADLLLDLGGSSSWAGPPASSDVWGDFTKASGAPSGQPSTGWVQF
The following text describes a protein:
Function:
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (3',2'-cGAMP) from ATP and GTP and plays a key role in innate immunity. Synthesizes 3',2'-cGAMP in a two-step reaction through production of the linear intermediate pppA(2'-5')pG (By similarity). Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses. Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 3',2'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish) (By similarity).
Sequence:
MELQANLENVLQKVNNFINIDAKRQIYAAHFDNLKNTIFNELRKNEVLAYLFNGFQLGGSYGDNVKVTVPNEYDLVFNIKFPEQPLIIVTADHELPGNVFLDFTRVIHKIAKEKQHEKILQHLKQWLDDENYLKVEKFQWFLRSCFIDVLTKMNFKITFKGRTSSLRYSREGPAHTIKVTESLNFDYSVDFVPGILLNANQCVTSNIVGQWEAIPKPTPTNNHLYKSFRASFYRQEQKIIKNQQQLKNVYRMMKKFRDSKTNMLKMKSYFIKTLFLWKSSRENVSYWSKPLTEIIIDMFKDMEKSLREEKLPFYWDRKLNLYDNYQPRLMREMLNCVESARETLEKAAKELTLPLQKRVFCIFCKLKI
The following text describes a protein:
Function:
May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons.
Subcellular Localization:
Cell junction, tight junction. Note=Localizes to the apical junction complex composed of tight and adherens junctions. In the liver and kidney, it is also found along non-junctional actin filament bundles in addition to the apical junction.
Domain:
The head region is responsible for both junction and actin filament-based distribution.
Sequence:
MELYFGEYQHVQQEYGVHLRLASGDTPKPRNSQPSKAGSYGVSIRVQGIDGHPYIVLNNTERCLAGTPFPENAPSFPSSVINNLSLHPSNGTVLKENTPEELQLPENPYLQTSPLRGQKQFSLHEGRNGVLERKDGPTKLPHVLNFQRHPELLQPYDPEKNEVNAKKHHPPESPWLRNATEDGTNCKKSRNCFPKSYGSQPNSPTSEDLAKTNMTAIRLCSSVVIEDPQKQTSVCVNVQRCAKEGVGEETLSPRRKSPTAPSPQAYSETKKNRPDVLPFRRQDSAGPILDGARSRRSSSSSTTPTSATSLYKFLLDDQECAIHADSVNRHENRRYIPFLPGTGRDIDTCSIPGVDQLIEKFDQKPGLQRRGRSGKRNRINPDDRKRSRSVDSAFPFGLQGNTEYLTEFSRNLGKSSEHLLRPSQVFPQRSVAQEHRGKHSPSSPPAKLQGAQGAHPKPPLQNKDGKVLNKGRQESTGACAPSLPAPNKKEEEIKIATATLMLQNRAVAATSDSGAKKISVKTFPSDSSTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGGTDNEDATKRKVNLVFEKIQTLKSRAAGSAQGSNQAPNSPSEGNSLLDQKNKLILEVSELQQQLQLEMKNQQNIKEERERMREDLEELRVRHQSQVEETATLQRRLEESEGELRKSLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSTKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNSSEQSQAEADLREKVLKEENEKLQGRIAELERRAAQLQRQMEDVKGDEAQAKETLRKCESEVQQLEEALVHARKEEKEATCARRALEKELEQARRELSQVSQEQKELLEKLRDEAEQKEQLRKLKNEMESERWHLDKTIEKLQKEMADIAEASRTSSLELQKQLGEYKEKNRRELAEMQTQLKEKCLEVEKARLAASKMQDELRLKEEELQDYQRAEEEALTKRQLLEQSLKDLEYELEAKSHLKDDRSRLIKQMEDKVSQLEIELEEERTNADLLSERITWSREQMEQMRSELLQEKAAKQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLENEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMGVNEQLQGQLNSLKKGLRLKTLSSKVLDDSDDDDLSSDAGSLYEAPLSYAFPKDSTIASQI
The following text describes a protein:
Function:
Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of OPG158 N-terminus.
Miscellaneous:
MISCELLANEOUS: Displays structure similarities to capsid proteins.
Subcellular Localization:
Membrane; Peripheral membrane protein. Note=Associates transitorily with crescent and IV membranes.
Sequence:
MNNTIINSLIGGDDSIKRSNVFAVDSQIPTLYMPQYISLSGVMTNDGPDNQAIASFEIRDQYITALNHLVLSLELPEVKGMGRFGYVPYVGYKCINHVSISSCNGVIWEIEGEELYNNCINNTIALKHSGYSSELNDISIGLTPNDTIKEPSTVYVYIKTPFDVEDTFSSLKLSDSKITVTVTFNPVSDIVIRDSSFDFETFNKEFVYVPELSFIGYMVKNVQIKPSFIEKPRRVIGQINQPTATVTEVHAATSLSVYTKPYYGNTDNKFISYPGYSQDEKDYIDAYVSRLLDDLVIVSDGPPTGYPESAEIVEVPEDGIVSIQDADVYVKIDNVPDNMSVYLHTNLLMFGTRKNSFIYNISKKFSAITGTYSDATKRTIFAHISHSINIIDTSIPVSLWTSQRNVYNGDNRSAESKAKDLFINDPFIKGIDFKNKTDIISRLEVRFGNDVLYSENGPISRIYNELLTKSNNGTRTLTFNFTPKIFFRPTTITANVSRGKDKLSVRVVYSTMDVNHPIYYVQKQLVVVCNDLYKVSYDQGVSITKIMGDNN
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
MSLVVNMQQRRTVADGRQNQDPNTIVSPAKRRTSKRLQISLEKSSQDDPNNSKNTAGRGGQMVLSALQKKQPTQQKITLEISRPAVVTPELEGGKRSIFDIRKRQLDEDESRAPLSVLDASKHDGVDNDWTTASPAKPTSKGGTHVYRKRSKTGTTPPTPSLRSFGRRQVTKEASPPPLPPPAFAPKSLSVGDKDNSESQALMPTGEQVAVMDILQPVRRQLLSPPKAREESDLYGSSATTNNMDVVTSYALLGDSETQVLGFENQIFSFIPTSPRRMHGLMNLGNTCYMNVIIQCLYNTSSFVDGMERFFGLHVKQNHSEGSEPFSYQDAESVHAALLKVFRDLKQAGRYEYVNPSVVKHAFAKHQSSFWGCIQQDAHEFFCSLIDRVQEEVSSELKRQFPIDANQPKLDTVCPTTQNFSCSVRNSLTCTGCGKVSSLEETYRDFCLALPEDERTHASKNCSLESLLNLYFQEITMSRKCEDCGVEVTKAKAQFLKLPHVLVLQLKRLHMDCDVPCTKVTAPVKFTPRLDVGPWCAPDKQKFWSPVSDDVQNFERKESVASPCSTQNGLGIVSQGNIDCESQELHAPLRTNADVGTNYRLYGVVNHLGFTASGGHFFADTYDPEGDRWLRCDDSFVTDVSSSNHLRIYVSSVLCCLHRGSRRTSGGLLTCEFAHR
The following text describes a protein:
Function:
Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture.
Subcellular Localization:
Nucleus.
Sequence:
MDSVETRYAHLLQPLRDLTKNWDIDLASQLGEYLEELDQMTISFDGGKTMMNFAEAALLIQGSTCIYGRKVELLHTLVFQTLDYISNKNKKRDKQGSSSDGNQEQAPSGSEGDGCEFDEIEQDENVNTHNITMKDPTEPVRIIRLPPESLIPAESHEKQKYPLLSLKGELLGSCKDFRINTFTMDEAGLMRLGSNTHFLKGVAEVQRDFSVHLPEPLQIEGEAAAANGGYDEEVDGGAEVLPPLEDHGMEVESDEWVERHEAPSEGRMLRPRPAVQPVSEEPKQLKETVDPWKLHDPYATFGEDKPLKAGKCYKVPAGLDESGKRKRKGPSKLQDFGTWFNKAFETADRKLKNGPTFPDLNYIFVSKMDQRLKVQRQMLRKRGVFVSDEELKKTYLEPENVEDQVEVIRHPDADGDDYSDEEHDNLADDLEPAEHLDDQEQIFQDLHMSRMSYEDLVKKSVDLFLVNSQKYAQETALSRRVKDWEDSINPHLAAQEISPAFDIHEYGDRIVHALSNVGVKKSFAFVVRGKENTEACRYMLAALQLANDYTVEVDKVDGLDCSVDTMELTLLTTQRAHERLKTYNATAATDIP
The following text describes a protein:
Function:
Component of the p-aminobenzoyl-glutamate hydrolase multicomponent enzyme system which catalyzes the cleavage of p-aminobenzoyl-glutamate (PABA-GLU) to form p-aminobenzoate (PABA) and glutamate. AbgAB does not degrade dipeptides and the physiological role of abgABT should be clarified.
Sequence:
MESLNQFVNSLAPKLSHWRRDFHHYAESGWVEFRTATLVAEELHQLGYSLALGREVVNESSRMGLPDEFTLQREFERARQQGALAQWIAAFEGGFTGIVATLDTGRPGPVMAFRVDMDALDLSEEQDVSHRPYRDGFASCNAGMMHACGHDGHTAIGLGLAHTLKQFESGLHGVIKLIFQPAEEGTRGARAMVDAGVVDDVDYFTAVHIGTGVPAGTVVCGSDNFMATTKFDAHFTGTAAHAGAKPEDGHNALLAAAQATLALHAIAPHSEGASRVNVGVMQAGSGRNVVPASALLKVETRGASDVINQYVFDRAQQAIQGAATMYGVGVETRLMGAATASSPSPQWVAWLQSQAAQVAGVNQAIERVEAPAGSEDATLMMARVQQHQGQASYVVFGTQLAAGHHNEKFDFDEQVLAIAVETLARTALNFPWTRGI
The following text describes a protein:
Function:
Is thought to be an important plant defense-related product against fungal pathogens.
Sequence:
MPLLILLMLLAAGAAGAESATPSLHIGVNYGANADNLPSPTSVATFLATKTTIDRVKLFDANPTFISAFAGTPISLAVSLPNSALPALADKATGLDAARSWIRANLSPYVPATNVTLLLAGNEILLSTDTNLILSLLPAMRRLAQALKAEGLTGVRVTTPHYLGILAPSDGIPSNASFRAGYNTKLFPAMLQFHRDTGSPFMVNPYPYFSYRPETLNYALFRPNSGIYDPATKLNYTSMLDAQMDAIYTAMKKLGYGDVDIAVGEAGWPTQAEPGQIGVGVQEARDFNEGMIRVCSSGKGTPLMPNRTFETYLFSLFDENQKPGPIAERHFGLFNPDFTPVYDLGLLRDGASVAPTPSPNPSPNPSPKPAPSGGGKWCVAKDGANGTDLQNNINYACGFVDCKPIQSGGACFSPNSLQAHASYVMNAYYQANGHTDLACDFKGTGIVTSSDPSYGGCKYVS
The following text describes a protein:
Function:
Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions.
Subcellular Localization:
Secreted.
Sequence:
MPSFKLFFVVALLVAIAFAVPAPSRRSVQKRSFKVPRQLNTAHPTGPNGMAAMRKVFRKYNFQVREDFMSREGLIGLTKASKNESSVQTQAAAGKNQSGTVMATPEQNAALFLSPVKVGGQTLNLDFDSGSSDMWFFSTELPQQAIQQHSAFDPAKSNTFKLTPNAKFKISYGDGSGAAGIVGTDVVEIGGVKVENQTVELANAVSQSFIQDVNTDGLVGLAFSNLNTVNDGTKKTPAKTFFDNVMGNLDLPVFTADLDPDGTGVYEFGKIDATKFEGQMAWIPVKAETGFWQFPSTKFAVGDKVIENPGASDAIADTGTSLLLVDQKVAEAYYSQVKGAQLNAQVGGFIYPCKAALPDLSVAIGDSYMAKIPGNQITFATVDKANTTCFGGVQGNQGAGLQIFGDTMFKAQLVAFNGGNQSLGFGQKPLAK
The following text describes a protein:
Function:
Immune regulatory cytokine.
Subcellular Localization:
Secreted.
Sequence:
MKAQRVPLWLLGAMLLQCSVHARGLRKCLISTDVHRAGETKDAFQNVTILSALETLHRIKPLDVCCMTQNLLAFYMDRVFKDHQGLNPQILRKISSIANSFLSMWKTLQQCQRPCHCRQEATNATRTIHDNYSQLEAQSAAVKSLGELDVFLAWLGKNHQGSSSI
The following text describes a protein:
Function:
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
Subcellular Localization:
Cytoplasm.
Sequence:
MFNRNNYSNPFGSNPPQRDGYSRPPQGYPPQHGAPDSGGYGTPPPRRPAPGARPPPQAPMGGRPSEGGVWALTPKESPNKECQFGNLVALSAQDFPRAQFGYEDILIIVNGLYVFSARILDEFPPGYIGLSSIQRPWARAGFRDSLDVRIYDPFRQGGEAYLGSADMEVKFAGKLRPDTLYDQDELLNSVIKNFESQIFAPGQPVLMDHHGVPLQLTVKTILRVSLTSEKDTSKVPETEPTARGILTKHTLINFFKDPQSEIQIKPAKNRPAANAIIQPDFNTEKMGIGGLDSEFHTIFRRAFASRIFPPDIVQKLGIQHVKGILLFGPPGTGKTLLARQIGKMLNAREPKIINGPERGSGAGGGTGVGDSVVNQLLSKMDGVDQLNNILLIGMTNRKDMIDDALLRPGRLEVHVEISLPDEAGRAQILGIHTQNMRQSDLMDPSVNLSELATLTKNYSGAEIAGLVKAATSFAFNRHIDSGKTVRVKDDAAEMKVNHSDFIHALDEIQPAFGVSEDEIKRCIEHGIINYSDKIDNVLQEGEALARGLGRPEQTTLWSVLLNGPPGSGKTALAAQIALDSGAPFIKMVCPEDVAGYNEAAKIQHILRVFNDAYKSQTSVVVVDDIETLIDYVSVGPRFSNSVLQTLKVLFKKRPPKNRRLLILATTSERALMKELNIYNSFNSDIDIPNVTSHEELRHVMEKSEVFASEQVAEALERIDPLKGETPYSMTFGVGIKKVFDGIELAKKTPDQLVNQFVRFINSAVQEGGLTTRRAV
The following text describes a protein:
Function:
Probable methyltransferase required to silence rDNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
SLGEKMKSKLESSRFRWINEQLYTTSGDHALTMFSAEPALFDVYHRGFRTQVEHWPVNPVNVIIQWLLERPVSLIVADFGCGDALIAQTVPNKVHSFDLVAKNDLVTACNMANVPLDSSSVDVAIFCLSLMGTDLQNYLLEAHRVLKKGGILKVAEVVSRVDPEAFVDSLSQLGFRLESRDESNKMFILMDFTKVKRKMPDCAELLGLKLKPCIYKKR
The following text describes a protein:
Function:
Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9 (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/PLAUR.
Sequence:
MGFIFSKSMNENMKNQQEFMVMHARLQLERQLIMQNEMRERQMAMQIAWSREFLKYFGTFFGIATISLAAGAIKRKKPAFLIPIVPLSFIFTYQYDLGYGTLLQRMKSEAEDILETEKTKLELPKGLITFESLEKARREQSKFFSDK
The following text describes a protein:
Function:
Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Involved in splicing pre-mRNA of the A1 cistron and other genes that are important for cell growth.
Miscellaneous:
MISCELLANEOUS: Present with 7330 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=This protein lacks a nuclear localization signal, it may interact in the cytoplasm with a component of spliceosomes via the leucine-zipper and then be transported into the nucleus.
Sequence:
MNTVPFTSAPIEVTIGIDQYSFNVKENQPFHGIKDIPIGHVHVIHFQHADNSSMRYGYWFDCRMGNFYIQYDPKDGLYKMMEERDGAKFENIVHNFKERQMMVSYPKIDEDDTWYNLTEFVQMDKIRKIVRKDENQFSYVDSSMTTVQENELLKSSLQKAGSKMEAKNEDDPAHSLNYTVINFKSREAIRPGHEMEDFLDKSYYLNTVMLQGIFKNSSNYFGELQFAFLNAMFFGNYGSSLQWHAMIELICSSATVPKHMLDKLDEILYYQIKTLPEQYSDILLNERVWNICLYSSFQKNSLHNTEKIMENKYPELLGKDNEDDALIYGISDEERDDEDDEHNPTIVGGLYYQRP
The following text describes a protein:
Function:
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
Subcellular Localization:
Cytoplasm.
Domain:
The PRC barrel domain binds ribosomal protein uS19.
Sequence:
MKPTERRILLGRIVGAFGVKGELKLESWTEPRSAIFRYQPWIVRTPSGQESVLSGVRGRDQGKNLIAVFPDITDRDTVEAMHGTEIYVARSALPPPKPDEYYWVDLEGLQVETVEGVKLGTVSHLFSTGSNDVVVVRGDRERMIPFVLPEYVKSVDFEANLIVVDWDPDF
The following text describes a protein:
Function:
Essential fertilization factor required for male fertility. Part of a conserved trimeric sperm complex with the essential fertilization factors IZUMO1 and SPACA6 which bridges sperm and oocyte membranes during fertilization by binding to IZUMO1R/JUNO on the oocyte.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MALSTLWLVLMLWTSLFSDSQCSTLSQAELQELEQIHTWVVSRSFPCSVTCGLGLLTQELCPIGVTRNISTSSCKLRTISCLDSWQCGLKTQTATVGRRLVLDCLEEVMEAMGRFSFVVSWRFAFAIITTDDSLFTRYEALSLDKVVLDPLREEDSGTYRCDVLDTGKRRVKRMYKGVKVLSPKDLSLDFAQGLIHWEIPESRFANLTSSRKVYSSSTIRNIVIISVPLSFAIAVVIFIFLFCYSRRARRAAHLCQDNI
The following text describes a protein:
Function:
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
Sequence:
FHHIWLRDHCLCKECLNPATHQREVDILKLQLNMAPPKVRVVSDTVELLWSDGHATDYKSSWLAQHAYKGNKKLRVKEELFLWDKERINSTTLPEFSFDAVTTNKKDLFEISKAIIKYGFAFVNDTPTELSAVEKLAKSLGCFVRETHFGRLWAFSNEVMDHADTAYTSGFLHAHNDNTYYTSPAGLQMLHCVHHDGKGGESLLVDGFNAANELKKEHPGAYTFLTTKVLPYRYIDSERHLKAFGPTIELDPFSKDFHQIRYNHYDRAVIDCLESDDVPSYYKAIQAYAEILRRPESEYWFKLVPGQLMVMGNWRVMHGRNRFTGRRDMQGCYVDKD
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MTTPSGLILAEQIIKSHFGSIVAKVCNCLLHHGSYTFRDVIRLTELEPKIVKKCLIVLIQHNCVQAYSLSRAEGVSKTVTIYMVIFDNIIHRMRFPKFLKIVEERLNSQCEVLLEAIFQHGRLTFEQLSQHSLSKDKAIDLHALKESFNRLVKGRYIERCPKPEPFLSSSAEDAPPPRKRNQKFVLDTMTMEKKALANATLSDAERFCEITNFECDNDTLEDKFIEGKRKYGSHEIDKKTEATIVEKEVLWRANFQNFINFLRAKACISYKSSRLTNDAGVILEALIECCSNQSTEMEASFDEIFGHIANHQAHMTKDYVGQVLDEIGCQQSMKGIVAFYTIDLKSIIEDSRKEEMETIILQRYGKSACKIFRLLSTKNQPFETDKISDMTFVDKKEAIALFYKLWNDKILHMEPVGSTDQKKGYYLWKISESASSDFFLENIYHTAANLNQRIDYHYEENKEFILLSAEDKKEMIKNQPERCKVYQHYVKTVKILETSLLNLDKLLLYFHDF
The following text describes a protein:
Function:
Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate. However, this apparent glyoxalase activity may reflect a protein deglycase activity, which could be the primary function of this protein like other DJ-1 superfamily members such as PARK7, YajL, YhbO and HchA (Probable). Is not able to use methylglyoxal as substrate.
Sequence:
MKKIGVILSGCGVYDGSEIHEAVLTLLAISRSGAQAVCFAPDKQQVDVINHLTGEAMTETRNVLIEAARITRGEIRPLAQADAAELDALIVPGGFGAAKNLSNFASLGSECTVDRELKALAQAMHQAGKPLGFMCIAPAMLPKIFDFPLRLTIGTDIDTAEVLEEMGAEHVPCPVDDIVVDEDNKIVTTPAYMLAQNIAEAASGIDKLVSRVLVLAE
The following text describes a protein:
Function:
Endoglucanase (EG) that cleaves the internal beta-1,4-glucosidic bonds in cellulose. The degradation of cellulose involves an interplay between different cellulolytic enzymes. Hydrolysis starts with EGs, which cut internal glycosidic linkages to reduce the polymerization degree of the substrate and creates new chain ends for exocellobiohydrolases (CBHs). The CBH release the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain. Finally, beta-1,4-glucosidases hydrolyze the cellobiose and other short cello-oligosaccharides into glucose units.
Sequence:
MDSPLTYLVKNVPDHLDISPRYMEGDWGTRMSRTMLFKSLISTVGVLATSASATIYYAGVAESGGEFGVYSGSGTVGTGLPGTFGRDYEFINKSAIDIYVDQNKANLFRVAFLLERMCPLATGLGSTFNETHYSYYADAINYITQTKSSYAILDPHNYMRYNDPSSQPYSGSIIGDTTDAKAATTAQFGAFWGELAKRFKNNQNVIFALMNEPHDMATSLVVKNNQAAITAIRKAGAKNLILAPGNSWTGGHAWTQGSDPSSALLQTLQDPLNNTAMDIHEYLDSDFSGGHSLCSSPASSNLAALTSWLQTYKLKAMITEFGGANGTECEPYISGMINYMAANDVYIGWTAWAAGPFWGANSPCCADSAQWGSLEPGSLAGDGSPGLYETVWLKTIQPLLPKTLQRSGPATVHH
The following text describes a protein:
Function:
Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, stim-1. Required for Ca(2+) and IP3-dependent contractile activity of sheath cells and the spermatheca. Affects brood size and somatic cell function (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPRSHDPSRVELLRQEGSTMNEKRVSISVEDIRGAVATWKTTSGAPITPYPLPQFFLQPPSSGGGSRNVGGGDGAAGNSKNGSMNSLRMQAYAKKTDDDVDLGHRGELDLSEKYNYDLSKAQLKASSRTSALLAGFAMVCLVELQYDDSTSKPLLIVLGVVTSLLVSVHLLALMMSTCILPYMEATGCTQDSPHLKLKFYIDLSWLFSTCIGLLLFLVEIGVIFYVKFTAVGYPTAGYITTAMLIPVGIVFVLFSYLIHKNRVSHSLGRFKDKVDTMKQFLDVEANLQKSTIAPSTIRDI
The following text describes a protein:
Function:
Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MESSGKMESGAGQQPQPPQPFLPPAACFFATAAAAAAAAAAAAAQSAQQQQQQQAPQQQAPQLSPVADGQPSGGGHKSAAKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF
The following text describes a protein:
Function:
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
Subcellular Localization:
Cytoplasm.
Sequence:
MLELKPPLVLLSGPAGFGEYLKLMDHRYVGGVLLKTVTLHPKEGNPTPRMADSDFYVINRIGLENPGIHAFVENIPELPVPMIASLGGDSFEEYLEVARVFKKVADRFYAVEFNFSCPNVKEGGLSIVKNAEEWKKLLNTLRKELPDSFLIAKVGVEGIFVEDAAEFVMKTGWDGITLVNTVRGLHFEKDTMILGGLSGPVLKPIALRAVYEVKKRFPELFVIASGGVYSVKDAEEFLKVGADVIGVGSALFKDPGVVEEIGKYLLEVKR
The following text describes a protein:
Function:
Receptor for both octopamine and tyramine, invertebrate neurotransmitters, and neuromodulators. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The rank order of potency for agonists is tyramine > octopamine > dopamine > epinephrine > norepinephrine > serotonin > histamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > cyproheptadine > dihydroergotamine > clonidine > synephrine. Tyramine has a functional role in the olfactory system as a neurotransmitter or a neuromodulator.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPSADQILFVNVTTTVAAAALTAAAAVSTTKSGSGNAARGYTDSDDDAGMGTEAVANISGSLVEGLTTVTAALSTAQADKDSAGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLLGLN
The following text describes a protein:
Function:
Microtubule-associated force-producing protein that mediates mitochondrial fission during interphasic growth and at cell division. Fission of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. With vps1, acts redundantly in peroxisome biogenesis, which is under cell cycle control.
Subcellular Localization:
Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes at sites of mitochondrial constriction.
Sequence:
MEQLIPLVNQLQDLVYNTIGSDFLDLPSIVVVGSQSCGKSSVLENIVGKDFLPRGTGIVTRRPLILQLINLKRKTKNNHDEESTSDNNSEETSAAGETGSLEGIEEDSDEIEDYAEFLHIPDTKFTDMNKVRAEIENETLRVAGANKGINKLPINLKIYSTRVLNLTLIDLPGLTKIPVGDQPTDIEAQTRSLIMEYISRPNSIILAVSPANFDIVNSEGLKLARSVDPKGKRTIGVLTKLDLMDQGTNAMDILSGRVYPLKLGFVATVNRSQSDIVSHKSMRDALQSERSFFEHHPAYRTIKDRCGTPYLAKTLSNLLVSHIRERLPDIKARLSTLISQTQQQLNNYGDFKLSDQSQRGIILLQAMNRFANTFIASIDGNSSNIPTKELSGGARLYSIFNNVFTTALNSIDPLQNLSTVDIRTAILNSTGSRATLFLSEMAFDILVKPQLNLLAAPCHQCVELVYEELMKICHYSGDSDISHFPKLQTALVETVSDLLRENLTPTYSFVESLIAIQSAYINTNHPDFLGVQGAMAVVLSRKEQNRLMLSQENDEPISSALDTVKPDGIELYSSDPDTSVKSITNKATNEITTLKSDDSAKMQPLDVLASKRYNNAFSTETAERKTFLSYVFGANNATRKAMSIDKSSSYPLNDSLSGGDTNHKNNHPLKMTDLSNEVETMALEDMSEREEVEVDLIKELITSYFNLTRKIIIDQVPKVIMHLLVNASKDAIQNRLVSKLYREDFFDTLLIEDENVKSEREKCERLLSVYNQANKIISTVF
The following text describes a protein:
Function:
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex.
Subcellular Localization:
Nucleus.
Sequence:
MVRTSQVVEQDLPEEGDRAKEKGISTPQPETAKDTWAAEPENSSKENEVIEVKSMGETQSKKPQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNAKFHPGETNFKLKLIKRNNQTVLEQSIDATSHVVSITSSGPGSGDSDPGISVSKTPIMKPGKPKADAKKVPKKPEEAAPENHVEGTARLVTDAAEILSRLGGVELLQDTLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLAPTKVSQPILQTALPCQILGQTSLVLTQVTSGPATVSCAPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANPPLTQTSERKKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAKDQLAIAASRHGRTYHAYPDFAPQKFKEKTQGQVKSLEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGQDAAAPNGALSRLDQLSGAQLAGSLPSPSPAITKSQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGSLKWMEQYQPQPVADDHGCDAPSRKGAKTILTESPKNGSEVAQPYYKDPKKLSEDDLEKLVPRAKAGSEQAKDGLPAKPSEATSDRSEGSSRDGQGSDENEESGVVDWVEVTVGEEDAISDRSDSWSQTAAEGPAELADSDSDSVPAEAGQA
The following text describes a protein:
Function:
Putative phospholipase.
Sequence:
MLLILTSFVTIAHASRRLAIVRDDQGGVSLLHNFASNAIVNSELTDVNSVGGYYQLRSAASTAEHDTDEERAYYMGYAEGYLLAPQIQDHMRNVMDDTFSELYDGNWPSKFREYASESRARIVHNYHTHGLEPFWVATYLMSDRYISGLHAGYMRYSIDNPSLKLIDISEDEFYMLSSIGDWEIGLELLLYGDNETVIQSIEHRAAEQLYSHCSGCVRIADDLDEIFTGHATWTSWGFGFLRVMKIYDFNFQTLNTTAQQISFSSYPGFVSSVDDFYIVKGTEKTTGHPIKFSVIETSYNIMNTTAALSAISRASNTSVLTWSRAMAANLIASSAANWPEVFTNKISYTYNDNWLITDYAILDTINSMCKTRGERDSYIRTHSPVILTSLEVVPGYYKSFDATSKLIHDGLYVSINVPADPYVRKYGYFHDDDPYEGSPRYSIFMREGTRVGNCKSMVTLMRHNSYKTDSASNKDPGSAIASRYDLRSYEECGKNPAPFGATDAKVVANYNFNDMSFWAIFGPTLGTHNDLPKFTFSDWPGLPHRGVPHNSLPVTTVPSLIIFKNSTPKSQSPIVTSVIIILLLAIISAVLGLVIRTVIHRKRVKLSNPKLVEGTENDEKRALINPDDPATVACTTQPVQGEKQ