lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II).
Subcellular Localization:
Cytoplasm.
Domain:
RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Sequence:
MPLLFFALAGCDGSPLCGGLSQRNQFVRLACSVTNFQSSAMFEGSESANTQEVKSESTLGSSLSACKKVLCSNSVLDSSEYWLKNDKTLCRIGFLEDQHDSGCPTICFVNLDRHTSDWHDDNYIKKLASVCPELPRLIESLGVRQPKENEILLLSSLEPPDSCQHDPSHPQSPRTADVCLVHCSCGRRPTQTSSIIFEINKFLIGLQSGQERQKHGRLAGQRAAEDDTNRSVSSIEEDFLTASEQLGEDSEEDPFRNDPENSLMPESVKVLRAAHAQKRSEIEREDSEDSETLCTSSNSQKLSRTYSAPARGRPTTPKQVKESAGHYATNLAESVLQDAFIRLSQDEPSFVAEAAVSVSSDISHSTEAPQRARACSFELPKIVIVQSPDNSEEVTEWPEVQSHATSEHDSGNKAKAKHGTHPPHNSPVGHPAKPLEIALACAASVIGTITTPQVTEQLTLESGEEYECEDEEEESETDQGEYSFSSAVCGMSQVAGAVAAVDLADDSGDNEDLADMYSASMGLLSVAQASTAIPLHCSIAEGTSVEAFRANVAEVLLREASAVFTHRQSYSSVANFLETTHNKIVDGITNPRRPYQEQQDVDNFTQEISDSIFQYALEKAEKRKELEGPGKDAPNIEGFLSDCVNNLLFDVLCVTSRKISDISNCNMESCDGQEGSVGYRAYEADSKAGREALSQLQHLIEPSQAYNHGERRSSVEKLSALIGKREREQKHIQEERENEARLKEPYRLALNRVTATMVKEQSDLQGQLGRSDKNADSALPSAESSPLHMQRGRAGGESETRQQSLSSSSGALVALKMDSGESKTPVTCFAEDLATTVVSMATELAAICLENSSGKQPWFCALNGGSEGPEGLLLPCRTAAALRRKETQNGTSVTKKHRPPRLSEIKRKTEEQPELMERLVNRVVDETVNLDEPTTTDPFALFASEVTARIMNCPELSVVDTSKSGQSSRSRLQCERWSSRGKASSYESIPEEDADPSGTSNTLGPGNRLGHNLSRGSSISKQSSCESITDEFSRFMVNQMETEGRGFDLLLDYYAGKNASSILAAAVQQAASKKNGHLNVRTSSCLSKQSSTESITEEFYRFMLKDMDKENKDYSMTKTKEWSNSLLPPSPRTPFCIRQSSVPDRRSSDSRLTVNSPIKANSFDGFAQNVHGDSLNIYPTNSVSSSGLCKSDSCLYKRGQTDQITDMLIHETWSSSIESLMRKNKIIAEPSEDSLELDSADSQPHVQQFANRLAADIVESGKSQLGGQQDVTAAACQPHIPVGERRHGFKHSRCNNSGNRPGVEHQENSCSSYSSSCVRQAWRGQREVPLIHIEPDQREEASEEKGGVETHHREASHQTQQQSGKGSETATKSSSDSDRVSSVATVPPAGVEVERRSLSASSEESGSGSWAQIATEDDPQEETTSSFIQLSEGNGNSSTSSLGLADLEGFPDFSISSNLISEERERKTSHCQDQADVTLVVLSEVTSGLSTAGSSCQRELLVLNCDLEPDCVDGELRAALQWISASELGVPALYFRKTHQHNLTKLHRVLQLAGQKAWRVGDLFSAVAQFCQLHQDLELKGRPLPSLFDWILKTKR
The following text describes a protein:
Function:
Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi.
Subcellular Localization:
Cell outer membrane. Membrane; Lipid-anchor.
Sequence:
MKGRWAKYVATGVMLAMLAACSSKPTDRGQQYKDGKFTQPFSLVNQPDAVGAPINAGDFAEQVNQIRSASPRLYTNQSNVYNAVQNWLRSGGDTRTMRQFGIDAWQMEGTDNYGNVQFTGYYTPVVQARHTRQGAFQYPIYSMPPKRGRLPSRAQIYAGALSDKYILAWSNSLMDNFIMDVQGSGYIDFGDGSPLNFFSYAGKNGWPYRSIGKVLIDRGEVKKEDMSMQAIREWGEKHSEAEVRELLEQNPSFVFFKPQSFAPVKGASAVPLIGRASVASDRSIIPPGTTLLAEVPLLDNNGKFSGQYELRLMVALDVGGAIKGQHFDIYQGIGPDAGHRAGWYNHYGRVWVLKSAPGAGNVFSG
The following text describes a protein:
Function:
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MIFFKPSWVTHEGSKPIFSVDIHPKGGRFATGGQGGSGGRIVIWNIAPVLSENDESSLKIPKMLCQMDNHLACVNVVRWSSEGHLLASGGDDKLVMIWRLTNEGSSSIFGSGKVNVETWKCVHTLNSHNGDVLDLAWAPHDGWLASGSVDNTVIIWNAHKFPEKVAVLKGHTGMVKGVTWDPVGKYIASQSDDKSLRIWRTCDWVQQEVVKDPFVDCSATTHVLRLSWSPDGQYLVSSHAMNGGGPTAQIIEREGWRQDKDFVGHRKAVTCVRFNSNILKKISAGSPKSQQYCCCAIGSRDRSISVWLTSLKRPLVVIKDLFDDSVLDISWSSNGLYLFACSWDGSVACVIFDQREIGIPLSIKEKNDLYERIYHKSLQKSWNLSFSGTQIVENPELLTAIDKINESSNNSVNLELPKPASRDVSFESPKPNTTILVPANKQVETRLPSGKRRITPMLLTTVQTTTVEATNSPPKTNLEVPTKESTSFSSSSPTKSKIVVETVVDQVKHPTFGGSSMKSSILNDANKLISAPPGTQINQLTCCEVPGDQPIVQFINVLDPLKLPSGTSVTKQCGTLKIQITNNCHKTSKGSLSSIEAYKNIDDKEPNWDTYIGSTIRCLAANRKFIVACCEDLSINCYEIKSGARPLPPIIIEDVVSSISLSQDSHCLVLTKTGLLYMWNFELCKSILSRISIRSLLNNKGVVSSCGLTSSNLPVITLTDGRAYSYASDLQTWVQLSNPLDPLSRVGGSLTRRVSPTLPLASLQRVMPFHGPHDTLPSGVTLSFLENQITASSIISSHDEYRHWLIATVNYLLDKGPECRLRVILDELLGPTYSSTAAKKSKNSDKILGKPSHAFLQEILEIIKTKLPWQRLYKEYREQLDEILHTM
The following text describes a protein:
Function:
Secreted chorismate mutase that is one component of a cocktail of effectors shaping the host metabolome and acting as virulence factors. The enzyme is taken up by plant cells, can spread to neighboring cells where it affects the biosynthesis of the plant immune signal salicylic acid by channelling chorismate into the phenylpropanoid pathway. Interferes with the activity of host cytosolic chorismate mutase CM2 through heterodimerization.
Subcellular Localization:
Secreted. Host cytoplasm, host cytosol. Note=Is translocated to host plant cells and spreads to neighboring tissue. The spreading is likely to occur through plasmodesmata.
Domain:
The extensive loop region (ELR) is specific for fungal secreted chorismate mutases and is required for the interaction with the host defense kiwellin KWL1.
Sequence:
MKLSVSIFVLLAVSAFGGGSAAAVSGKSEAAEIEAGDRLDALRDQLQRYETPIIQTILARSALGGRAPSEQDEVRAALSRNAFEPSEVISEWLQTESGARFRSTRPLPPAVEFITPVVLSRDTVLDKPVVGKGIFPIGRRPQDPTNMDEFLDTSLLSLNQSSTVDLASAVSLDVSLLHLVSARVLLGYPIALAKFDWLHDNFCHILTNTTLSKSQKLANIIQQLTDHKQEVNVLSRVEQKSKSLSHLFRNDIPYPPHTQDRILRLFQAYLIPITTQIEAAAILDHANKCT
The following text describes a protein:
Function:
E3 ubiquitin ligase essential for DNA replication origin activation during S phase. Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase.
Subcellular Localization:
Chromosome. Note=Association to chromatin is cell cycle-regulated, absent from mitotic chromosomes, is associated with chromatin from G1 and partially released from chromatin from mid S-phase.
Sequence:
MAQTVQNVTLSLTLPITCHICLGKVRQPVICINNHVFCSICIDLWLKNNSQCPACRVPITPENPCKEIIGGTSESEPMLSHTVRKHLRKTRLELLHKEYEDEIDCLQKEVEELKSKNLSLESQIKTILDPLTLVQGNQNEDKHLVTDNPSKINPETVAEWKKKLRTANEIYEKVKDDVDKLKEANKKLKLENGGLVRENLRLKAEVDNRSPQKFGRFAVAALQSKVEQYERETSRLKKALERSDKYIEELESQVAQLKNSSEEKEAMNSICQTALPADGKGSKGSEEDVASKNQGDSARKQPSSSTSSSSHLAKPSSSRLCDTSSARQESTSKAELNCSKNKDLYQEQVEVMLDVTDTSMDTYLEREWGNKPSDCVPYKDEELYDLPAPCTPLSLSCLQLSTPENRESPVVQAGGSKKHSNHLRKLVFDDFCDSSNVSNKDSSEDDISRSENEKKSECFSSPKTAFWDCCSTSYAQNLDFESSEGNTIANSVGEISSKLSEKSGSCVSKRLNSIRSFEMNRTRTSSEASMDAAYLDKISELDSMMSESDNSKSPCNNGFKSLDLDGLSKSSQGSEFLEEPDKLEEKTELNLSKGSLTNDQLENGSEWKPTSFFLLSPSDQEMNEDFSLHSSSCPVTNEIKPPSCLFQTEFSQGILLSSSHRLFEDQRFGSSLFKMSSEMHSLHNHLQSPWSTSFVPEKRNKNVNQSTKRKIQSSLSNASPSKATKS
The following text describes a protein:
Function:
May have a roles as negative regulator of innate antiviral response.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEGMDIDLDQELMQKFSCMGTTDKDVLVSEFQRLLGFQLNPAGCAFFLDMTNWNLQAAIGAYYDFESPNINTPSMSFVEDVTIGEGESVPPDTPFTKTWRIQNTGTESWPPGVCLKYVGGDQFGHVNMVMVRSLDPQEISDVSVQMRSPAVPGMYQGQWRMCTATGLFYGDVIWVILSVEEGGLLGVTQQLSSFKTEFNTQPHRSLEGDYNPFASPQKNKQDTNEDHLKDPGGPWEAPLDSIQQDQNGLNHSSVNITPNGLQNNLSVVTYSQGINGPFPFGQS
The following text describes a protein:
Function:
Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAARKLQQEIDKCFKKVAEGVATFESIYEKIMQTGNPSQKEKLEDQLKKEIKKLQRSRDQIKTWAAMSEIKDKKPLLDHRKLIETPTDHVQQMERFKAVEKEMKTKAYSKEGLQLASKIDPKDKERMEVVEFLQHMNEELERQIETLEAEAETMQVVGKKSKKADASKAERIAEMEETVERHRWHQTKLELLQRALENSSIDTEQVKEIEESIKYYVEENQSPDFMDDDTIYDELNLQEEEVIFGMGGEMDRVSSQDTQSIQDETPELEGKPSAPETQGRRTDAVRRAKTVDAAQVSITGVGDIAYAITWYIELSKHYASAAAAAAASDKNGVGIAPLPPPPGGSAAPSGLAPAGARASASTSPATTHPKLAQTSSEQVQPAQARSPAATPSHPVTAAVEKEALSRAASAEDAVKASRRTPAPERLEEEGSQAATPPLTNGDSHAEDEEEESVYHLPSSLQDLLDSFEATKNEINASVSKPPDERMLASSMATAPDSADTEAPRHYQPQNPYPFTPAHYPQEPLPIFDDPRLYQRIETDALFYAFYYQQGSFQQYLAAKALKSQSWRFHKQYQTWFQRHEEPKAITEDYEQGTYRFFDYESTW
The following text describes a protein:
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MSDAKASGAQPNLAALASKNSQAVRRRAAQQAAAKPNSPRAAGAGGSSSTMMRLYTDDSKGLSVDPVVVLVLSIAFVFSVVLLHIIGKFMRWFSK
The following text describes a protein:
Function:
May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Sequence:
MKNEDSSLTRFLVKNLQPLTTADPVILAEYVIALLKKDKSNKELQRLCVDNLVDFLGHSTDTFIKTLFQALEDGSVVRPVDNNDENNISEHLELKVLPTKDEDNSRSKKEHELSTSSRPASDPEDQEISDDDDDRNHKHRRRDSQPLSFGKDDQRKFIGHPRGKRNRTFDNGDLSQENHLRSSDAKREYNPSLDRELSSKYEKRRPGMVYSGPRFDPSTSFSRPVGGRGRGRGLGSWNQQDSRFPSLGALDFAPHLVSQGPTHPSLFVPNSLPNAASVQSASWAPFGFVPGMPNMCLDPLNSLGLQGAVHSSINSQLNLGMHRQRCRDFEEQGFCLRGDMCPMEHGVNRIVVDDVQSLSQFNLPGSVSSTHHSSQITVSGTLNPNVNGKPLPNKNSKVGLIDDSSIPAMESDVYDPDQPLWNNIHSEPSKGLLNLPPKVDGMESLWDAAPSHVHGFKFSDRVDSEDPPPASNLTDNNSHVKVSSAKLKIPRRNENIQTSTYSFDNGTNGTRDRTITNTNVGINHRKQISVGDVDGKAVDSSSTQIFHKDTRGNTIKASQKAFRTLFVIGIPQINNKRTALLSHFGKFGNVIHIHIPQVGDKAFVQFSKREEAEAALQAPDAVMGNRFIKLFWANRDNIVDDKEGNKMCTSVGLLPRADCAVSSKLSNTARQEPISSDVQRKVSSVSTLKPVPTQKKRELELLKEELRKKQEMLAQKRNDFRNQLNKLEKQAIPFFEEDSPSKQPSKKHKSEMDPETLKTTVAKVEMCMDVDAQPDAEKPNSGIIRNPSIFQNKNNSPALHRQLSVNRYKLDNRPTGFRILPPLPEDFLDVSVMKGHFLIFNNLSTIELEDIEVKSSTGTLKPSQSCSAFINFTTRRSAEKAFLSGKCWKGQNLQFEWLKASSVINHRSVQKVPLLSNFNEVEAFRVEPQNVVSKHLSSPAKPTSCSVSNTMKTEADEKSLPNAADTYNTVKTETVEKLMPNAVDSCITVKTETDEEAMFKAVDANNSREHLDVDHNHESLRTMSTPTILSPSKSPPNSELLFVEDDNSIGSKH
The following text describes a protein:
Function:
Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE). Unlike yeast, exhibits no effect in transcription regulation.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MSFTFTKSDGSSILFAVSKNFEHIRGFKNAIDCFKGKIEFLSFDKVDPTKHDYYLVAEDERVSDLDIPKGFFERNPEFRHKMLKIAWITQCIEQGKLLPTESFEVELNQDDVNRTHDGFRKRELFTLEDEKILIDHVHKNDINRFGTKVYEELARKYPQHSLESWRQHYKYMKKRLPPVSDSDESNYCQRIIVKPYSSQKDYTQSTHEQTLSSPISKSASVSKSENKALVNNKRYSDSYFYFSKMRRISIDVDYVDEDLNLINAYLSQFGKKRSLNELCALLSRRFSNRHTFSEWRALFMHFFPFINSEGVDPAILSDRETSAMLDETSDNEVADIDDQMIERKYLFSASEPNTVKSTNRLIFSERKAYAADDSIDNTPSKVPIVNSLSDPRTNRPFFYSNPDSMYRSISNPLHLVDSQHLSPLNRKTHFNNPIGQPQFTCLDDHEKTLRETSFRSLDDMSLRKSNSDNIFVKPGEDLEIPLLSDYSDSENISEKSSDDEEAFEKQVTSSYSSPIKVKSQGKSSKGSSGLDVREHEGSDDDAEVFVDRSPESFGATKVAHTSLEGNAASHKKVEENMQQPVTKKQKKYRMVNEEAHTGPTIIIPSDNNEKVTTLPAGHVPSEEKGKFINLAMHELQNEVSILRSSVNHREVDEAIDNILRYTNSTEQQFLEAMESTGGRVRIAIAKLLSKQTS
The following text describes a protein:
Function:
A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity (By similarity). Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
Miscellaneous:
MISCELLANEOUS: Disruption of the gene was not associated with abnormal growth and development or redistribution of interacting proteins. However, a modulation of expression of selective ion channels in the kidney, as well as increased serum cholesterol levels were observed.
Subcellular Localization:
Membrane; Peripheral membrane protein. Cell membrane. Note=Localized in the brush border membrane of renal proximal tubule cells. Associated with peripheral membranes (By similarity). Localizes to the apical compartment of proximal cells and to sinusoidal liver membranes (By similarity).
Domain:
The PDZ 2 and 3 domains seem to be involved in the interaction with SLC26A3; Interaction with the C-terminus of CFTR could be mediated through independent binding of PDZ 1, 3 and 4 domains; The PDZ 1 and 3 domains seem to be involved in the interaction with SLCO1A1; The PDZ 1 domain interacts with BCR; The PDZ 2 and 4 domains do not interact with the C-terminal region of SCARB1.
Sequence:
MASTFNPRECKLSKQEGQNYGFFLRIEKDTDGHLIRVIEEGSPAEKAGLLDGDRVLRINGVFVDKEEHAQVVELVRKSGNSVTLLVLDGDSYEKAVKNQVDLKELDQSQREAALNDKKPGPGMNGAVEPCAQPRLCYLVKEGNSFGFSLKTIQGKKGVYLTDIMPQGVAMKAGVLADDHLIEVNGENVENASHEEVVEKVTKSGSRIMFLLVDKETARCHSEQKTQFKRETASLKLLPHQPRVVVIKKGSNGYGFYLRAGPEQKGQIIKDIEPGSPAEAAGLKNNDLVVAVNGKSVEALDHDGVVEMIRKGGDQTTLLVLDKEAESIYSLARFSPLLYCQSQELPNGSVKEGPAPIPAPLEATGSEPTEDAEGHKPKLCRLLKEDDSYGFHLNAIRGQPGSFVKEVQQGGPADKAGLENEDVIIEVNGENVQEEPYDRVVERIKSSGKHVTLLVCGKMAYSYFQAKKIPIVSSMAEPLVAGPDEKGETSAESEHDAHPAKDRTLSTASHSSSNSEDTEM
The following text describes a protein:
Function:
Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region.
Sequence:
MPIGFQQIQNEEEDADAPPPPGLTPTLAMAVGTAVLGSLQVGYHVGVINAPQKVLEDEYNTTWTQRWGEPPPPTTVSTLWALSVAIFSVGGMMASLMVGVVAERLGRKHAMIATNALAFVGGAMMGAAKWGPSYVLIIIGRFLLGAYSGLVSGLVPMYVGEIAPTHLRGALGTLHQLAVVIGILGAQVLGLGALLGTARRWPLLLGLGLCPAALQALLLPRCPESPRFLLGRERRGAAMHGTHSAPSASSSSSSSSSSVSRLRSSLWSSSLSLSLLLFSLLSSLLSSSSSSSSSSSSSSSSLLALSSSSPPPPSSSLLWSSPLLSLLLLSSLLSSVLLLSLSSSSSLSSSSSSSSSSSSSSSSSSSSSSSSSSRLRSSLWSSSLSLSLLLSSLLSSLLSSSSSSSSSSSSSSSSLLALSSSSPPPSSSSLLWSSPLPSSLLLSSALSSVLLLSLSSSSSSSSSSSSSSSSSSSSSSSSLSRLRSSLWSSSLSLSSLLFSLLSSLLSSSSSSSSSSSSSSSPSLLALSSSSPPPSSSSLLWSSPLPSSLLLSSLLSSLLLLSWSSSSSSSSSSSSSSSSSSSPSSSSSSSSSSSSRLRSSLWSSSLSLSLLLFSLLSSLLSSSSSSSSSSSSSSSSSSSSSSSPLLALSSSSPPPPSSSLLWSSPLLSLLLLSSLLSSVLLLSLSSSSSLSSSSSSSSSSSSSSSSSSSSSSSSSSRLRSSLWSSSLSLSLLLFSLLSSLLSSSSSSSSSSSSSSSSSSSSSSSPLLALSSSSPPPPSSSLLWSSPLPSSLLLSSLLSLLLLLSLSPSSSSSSSSSSSSSSSSSSRLSSLSLLWSLLWSFSLSLSHIAPHCPIHPTSVPHNPTHCPIHPTSVPHNPTHCPITPYIPHPCPITQDNPYLCPITPHIAPYTPHLCPITPYTPHLCP
The following text describes a protein:
Function:
Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Miscellaneous:
MISCELLANEOUS: Present with 5110 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSQRKLQQDIDKLLKKVKEGIEDFDDIYEKFQSTDPSNSSHREKLESDLKREIKKLQKHRDQIKTWLSKEDVKDKQSVLMTNRRLIENGMERFKSVEKLMKTKQFSKEALTNPDIIKDPKELKKRDQVLFIHDCLDELQKQLEQYEAQENEEQTERHEFHIANLENILKKLQNNEMDPEPVEEFQDDIKYYVENNDDPDFIEYDTIYEDMGCEIQPSSSNNEAPKEGNNQTSLSSIRSSKKQERSPKKKAPQRDVSISDRATTPIAPGVESASQSISSTPTPVSTDTPLHTVKDDSIKFDNSTLGTPTTHVSMKKKESENDSEQQLNFPPDRTDEIRKTIQHDVETNAAFQNPLFNDELKYWLDSKRYLMQPLQEMSPKMVSQLESSLLNCPDSLDADSPCLYTKPLSLPHPTSIFFPNEPIRFVYPYDVPLNLTNNENDTDNKFGKDSKAKSKKDDDIYSRTSLARIFMKFDLDTLFFIFYHYQGSYEQFLAARELFKNRNWLFNKVDRCWYYKEIEKLPPGMGKSEEESWRYFDYKKSWLARRCGNDFVYNEEDFEKL
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Sequence:
MIVHVYSMMALSMSQSHPLSLIEPPDVIPPTSSSLLQNSTLDIGAHNQQYQTLKMASVDEVKVGDKIPSVVLKEGQADYEKPVDVNIGELIAGKKVALFAVPGAFTPGCSKSHLPSFITAQKELREKGVDLTICIATNDAYVMEAWGRTSGGADAGIRFLSDANAELSRALGLSMENDVMVRTKRFSLIAEDGIVTHYFSSADASDNTWAPNVLAAL
The following text describes a protein:
Function:
Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MAPVLSSNWKSLQAILKKNPPASIEAQKRKAAEPSERTKDSIAKRRRLEGNTLKTRSIAEAKGTATKRKAMGGMGSSPILESTEDDTPLPKNAPSASLALWAEDNDISAKDLAEAYGGNLKDTTIQGARADKINGGLSTDVDIGKYIGIDCEMVGVGGAEDRSVLARVSIVNFHGTQVYDSFVRPQEFVTDWRTHVSGVSTKNMATAREFDEVQKDVAEILKGRILIGHAIKNDLEAMILSHPKRDIRDTSKFSGFRKYSNGRTPSLKKLSKEILGVDIQGGEHSSIEDARATILLFRKHKSAFDIEHAKHNPSHSGASSKSKPKKKKKGKR
The following text describes a protein:
Function:
Required to load the replicative helix DnaB onto single-stranded (ss)DNA, to initiate chromosomal replication. Also loads the DnaB in the replication restart primosome (composed of PriA, PriB, PriC, DnaB and DnaT; DnaG primase associates transiently with this complex). DnaC alters the inter-domain and inter-subunit interactions of DnaB, inducing an open ring conformation that allows ssDNA to access the interior of the DnaB(6):DnaC(6) ring. Has ATPase activity only in the presence of DnaB and ssDNA. ssDNA binds to the central pore in the DnaB(6):DnaC(6) complex, making contacts with both subunits. Mutations in this protein can bypass the need for PriA recognition of collapsed replication fork substrates in order to load DnaB onto recombinational intermediates in vivo.
Sequence:
MKNVGDLMQRLQKMMPAHIKPAFKTGEELLAWQKEQGAIRSAALERENRAMKMQRTFNRSGIRPLHQNCSFENYRVECEGQMNALSKARQYVEEFDGNIASFIFSGKPGTGKNHLAAAICNELLLRGKSVLIITVADIMSAMKDTFRNSGTSEEQLLNDLSNVDLLVIDEIGVQTESKYEKVIINQIVDRRSSSKRPTGMLTNSNMEEMTKLLGERVMDRMRLGNSLWVIFNWDSYRSRVTGKEY
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MGGGHYEAPRVPTRQEMVDAKVPLHYRDTCAGLLIPLNECRRATYFLPWKCQDLRHAYEKCQYEEWKTRVELLKNQD
The following text describes a protein:
Function:
Cationic peptide that possesses multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor. It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism.
Subcellular Localization:
Secreted.
Sequence:
FLSEPGNAYKQCHKKGGHCFPKEKICIPPSSDFGKMDCRWRWKCCKKRSGK
The following text describes a protein:
Function:
Involved in the decoration of cell wall teichoic acid with galactose and glucose.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNKIRKWLDKIPWYTDEIHSILMYLIMGGFTTLINIVTFWLCTYVLNWDYRIANTIAWVASVLFAYFSNKKYVFESYTPTWKERAREVTSFFGFRFLTYLVDILVMILLIEVLSINELWAKIWTNVIVLVLNYVFSKWIIFKVKK
The following text describes a protein:
Function:
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Sequence:
MGDPRSVIKEDRWDVRKDIGLLNGELKRKGTSSHSRREQNSSDRKRKKDTSQKSKNENKDRSSIKRTSSRMEQEKSRCSEPHGKSVQEHRFVSYEKSKWPERTALGNSEDKTNIIMDHSSVSDDDMEETPGFLDMNNNISAVSREERHSDRALCSENQNERSEEKSDVEKNKMVHKVERKEKNCKANKTRDGTTEHSDSQSDPGAEEEDGNNAMNREEIQREEGGKSRDSKMDKPSKSGKNKVKKEKEQQSKFTDNSKEQRAREKKIDEAEERKRRKLHKGKKEEDGNPRRGDEKKKDVKKSKIAKDEPEEGGTAKKRKRENREEENKEKKLKKEEQEKKKQEEEANKWKWWEEGQSSDGTKWQFLEHKGPLFASEYEPLPENVKFYYSGKPVKLSLTAEEVAVFYAKMLDHEYTTKEVFQKNFFHDWKQEMTAEEQSLIKDLSKCDFKEIHQYFEKKTEEKKAMTKEGKQALKKAAEMVTEEYGYCLLDGHREKIGNFKIEPPGLFRGRGDHPKMGKLKRRIQPEDVIINCSKESKIPVPPQGHKWKKVQHDNTVTWLASWVENVQGGIKYIMLNPSSKLKGEKDWKKYEVARKLKDKVDMIRHQYRQDWKAREMKRRQRGVAIYFIDKLALRAGNEKEEGETADTVGCCSLRVEHITLHRRLDGQDHVVVFDFLGKDSIRYCNQVPVEKAVFKNLKLFMDNKNPDDDLFDRITTSYLNKSLQESMDGLTAKVFRTYNASFTLQQQLNKLTDPDQTVAEKILAYNRANRAVAILCNHQRAAPKTFEKSMQNIQEKIAQKEQQLEDAKKDLKKAQEEYNREPSDKLKKLVEKKEKLVKRLEEQLKKLILQATDREENKQIALGTSKLNYLDPRITVAWCKKYGVPIEKVYNKTQRDKFAWAIDMTEEDYEF
The following text describes a protein:
Function:
Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAPKHKSSDAGNLDRPKRSRKVLPLSEKVKVLDLIRKDKKSYAEVAKIYGKNESSIREIVKKEKEIRASFAVSPPTAKVTATVRDKCLVKMEQALHLWVEEMNRKRVPIDSNMLRQKALSLYQDFSKGCSETDTKPFTASKGWLHRFRHRFSHHYKKKKGIMAQVAMSTLPVEDEESSESRMVVTFLMSALESMCKELAKSKAEVACIAVYETDVFVVGTERGRAFVNTRKDFQKDFVKYCVEEEEKAAEMHKMKSTTQANRMSVDAVEIETLRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGISFIIKRPFLEPKKHVGGRVMVTDADRSILSPGGSCGPIKVKTEPTEDSGISLEMAAVTVKEESEDPDYYQYNIQGSHHSSEGNEGTEMEVPAEDDDYSPPSKRPKANELPQPPVPEPANAGKRKVREFNFEKWNARITDLRKQVEELFERKYAQAIKAKGPVTIPYPLFQSHVEDLYVEGLPEGIPFRRPSTYGIPRLERILLAKERIRFVIKKHELLNSTREDLQLDKPASGVKEEWYARITKLRKMVDQLFCKKFAEALGSTEAKAVPYQKFEAHPNDLYVEGLPENIPFRSPSWYGIPRLEKIIQVGNRIKFVIKRPELLTHSTTEVTQPRTNTPVKEDWNVRITKLRKQVEEIFNLKFAQALGLTEAVKVPYPVFESNPEFLYVEGLPEGIPFRSPTWFGIPRLERIVRGSNKIKFVVKKPELVISYLPPGMASKINTKALQSPKRPRSPGSNSKVPEIEVTVEGPNNNNPQTSAVRTPTQTNGSNVPFKPRGREFSFEAWNAKITDLKQKVENLFNEKCGEALGLKQAVKVPFALFESFPEDFYVEGLPEGVPFRRPSTFGIPRLEKILRNKAKIKFIIKKPEMFETAIKESTSSKSPPRKINSSPNVNTTASGVEDLNIIQVTIPDDDNERLSKVEKARQLREQVNDLFSRKFGEAIGMGFPVKVPYRKITINPGCVVVDGMPPGVSFKAPSYLEISSMRRILDSAEFIKFTVIRPFPGLVINNQLVDQSESEGPVIQESAEPSQLEVPATEEIKETDGSSQIKQEPDPTW
The following text describes a protein:
Function:
GTPase-activating protein for the ADP ribosylation factor family.
Subcellular Localization:
Cytoplasm. Cell tip.
Sequence:
MDGSDSLLKSVDVSKLDNGSTISFRAREDGFLESISSSSGKLVDMVLDSTSKECLPKFSFQNKLDFYFLFSDRVLQLQKERKVLVLIHCESLQSFDSFFAQKLKYADLISSDNVHEIFLPDSNAANIRYHWEWSPPSGKLLEYECKNYSCIAVYSTEDCTLERISKFSYYTVSRCGDSMDDTFFSESQRVTSPLTTSQTVQTQPPQSPEAKTELSLINTKTVIFPENYEDGPSFRSMLHELEQKSSLMKYYCKKIMKRIVQLSDAYDASQVAVMKLSETLSEASNSTSMNMDILLDSYLTKAMDIHATFIQKLNYDLINLLYEPFHNIYSSFIKPIDDRRLEFDEQSKSFYGSLSRYLSAKKDKKGGDSKFFQKEKTFALQRYDYYCFMQDLHDGSIINDINGIFLQYFHRQYDHIALFSNLMNSVLPNLQQLNLKLEKTKWSTTRRDKGREMHRSQVIQTSGRPKSMAPPSPSPISPSFPLHEIQSPMPNRRMAASADDISQTSNFTTEIKGKCISNGGSASPDKIFKEGLLLVFGATELGTDLAMVSKAAWHKHWIVVENGSLWEYANWKDSVKSNVSSISLKHASADKVRKQGRRFCFEVVTPKLKRLYQATSAEEMDSWIEAICEAAKISSFQLSRVATPLSASVRRPSKVFPLFSTSFETTPISRKLSGSGIKKAFSRKGSWNLQQFFRSDNSGTMHMEQLERYHASANIFIQMLRKTDVSNSVCADCGSVKDVTWCSINIPVVLCIECSGIHRSLGTHISKTRSLLLDSLSQQSKVLLCKIGNAAVNRVYEKGLSNPSLKPKPEHNAQVKLAFAQKKYVEHAFIDFAGVDADATLLEGLEQNKISKILLGLAAKPNFEENGVVFLKAVTRDTSKLHLLELLFMNGLLLPDSEQLSEHVSPDMQSYLSQKQFTKYLKE