lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MLVLLMVLVFTLVLLFAFYLINFLLSIKDMGKNKISAFECGFVSVGKIQNSFSIHFFIMMLMFVIFDLEIVMFLGILVSDLSSYISFLMMFIFILGGFYMEWWYGKLVWVI
The following text describes a protein:
Function:
Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). Required for the maintenance of neuromuscular function.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MACLRKLKEDIQVLEKLFPKNHNRFQILSASVDELSMKFINAENKGIIVTANIQENYPRQPPIWFSESDDVPVIGMSLQRLTETEESTNILHQVHRLVSDLCSFYNLQMPCELPQIAPPVRDDIDEGRGSDISDTTSEPIDDDMAGDGEVDDDDEEEEDDEDADGDIEIVEMAEEDPTSQHDVGVSKEGLDMLDKVSKINRQQHLDGKVQGSITATDRLMKEIRDIHRSEHFKNGIYTFELEKEENLYQWWIKLHKVDEDSPLFEDMKKLKKDHNQDHLLFSFTFNEKFPCDPPFVRVVAPHINQGFVLGGGAICMELLTKQGWSSAYSIESCILQIAATLVKGRARISFDAKHTSTYSMARAQQSFKSLQQIHAKSGWYTPPKTEG
The following text describes a protein:
Function:
Synthesizes cyclic GMP (cGMP) from GTP. May play a role in embryogenesis.
Miscellaneous:
MISCELLANEOUS: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.
Subcellular Localization:
Cytoplasm.
Sequence:
MYGLIIDHIATYIKEKYGESTWSEVKFVSGVTDDTFQMDKKFSEGLSHKLIWACHDVTGDPVDELMTNIGTSFYKFLTKFEFNKVLRVLGRTFPQFLNGLDNLHEYLRFTFPKLKPPSFYCEHESRTGLTLHYRSKRRGFLHYVQGQIRNISQELFQTEVVIELLDIEHDLNLEHVIMRLHFNNLDFNRQGTAYRNLNDSILEKVKITSDIFFDIFPFIIVFNRGMRIRNIGIGLLRVMAGIVGKKINQTFLLMRPFIRFRWEEIMLHSNNIFELISSDPIQEDEDGILVYKTTDVDQMTEERHRMGDGEREKFLSLKGQMFYMEEWESICFVGIPVMSHLPQMYKSGLFINDFALHDSSRDLVLASTQQSAELKLLLHQEAQKSRNMRENMNRLKKERRRTDKLLYQMLPKSVANQLRHGESAVACCERFDSVTILFTDIVEFTKMCSSLTPLEVIEFLKVIYTNFDKIIDTHGVYKVETIGDAYMVVSGAPTKTEHDAEFILDCASQFLVEAGKMVNMNNKIHKIDIRAGVHSGSVVAGVVGLSMPRYCLFGETVYVANKMEQNSSPMKILVSETTHNKIEESDPGLYQFERREEIEIKDDQTIQTFFVVSRHGPHRVPSPRNCESRQDDSQTEDDDDDELLLPRKSGRKSPTSEAEEELKKKGQLSFTPVSDAGIECHSRNSNKTPRQSQDLTPRKSIT
The following text describes a protein:
Function:
Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Sequence:
MDLAAFTANNKSSAVIKSAVPDVAKSYPCMLGVDEAGRGPVLGPMVYGIAYCPVEFEEDLKRLGFADSKTLTEEKREELVGVMEQRSESLGWMVEVISPTVICNHMLNMSKYSLNAISHDSAIGLIKQALDDGVCVTEVKLERPENPLHESKLPKLRHASRNTNRHAFGARTIIFRIALLFHRHFECSTFHLSKKKFHGGRSMDCSNSLLLWGVVLLSDPATKKFLSAHVDNVFGFPSLVRFSWSTAEKLLEDNSATVSWYAEKATQNNIASIQSFFKRDPNHTAKVAPKESAFFVDRALAQVSDL
The following text describes a protein:
Function:
This protein plays a role in synthesis of starch. It catalyzes the synthesis of the activated glycosyl donor, ADP-glucose from Glc-1-P and ATP.
Sequence:
MRGVSEDHETYHIIQYMCLRSSYPESNDFGFEIIPLAVKEHNIQEPLLRTPRADPKNVASIILGGGAGTRLFPLTSKRAKPAVPIGGCYRLIDNIPMSNCINSVIRKIFILTQFKSFSLNRPLSRTYNFGNGVNFAVLVFSKLTLQFLVYHQKKLPGSHTLVLRSSPLALKEHTVQCLLLIAIIIHMMEHNYNSDSDDEYFSAGEGEGPYYVVRPPIYSYGDDGFHLFGFPHLKLGESIGLVGPKLTGKTTVLNLLAGNLVPNLCKPEEPPQWEAIMHHLDIIKEHPRAKEFRTYLARIRVNDLKVSMKTQLVSYEELIEMQQQKTFQETVDILGHHSRRNPYKIMEMCNMVGIDDGILYSLPSQLTKAGIQKVKFAAALLKEADAYVLDEPSSYLSRKERLGVSHAIVSVIGPIKYVVVADEDANMVEHISKSIFKVDGTPNQNGHVKPFPYHRF
The following text describes a protein:
Function:
Serves as a base for tail tube protein polymerization and acts as a template for tail length determination.
Subcellular Localization:
Virion. Note=Probably present inside the tail tube.
Sequence:
MEGARLQAVVTANIREFQRKMAAVNRIVRTTANRVTVTVDSRTEKFENAMNRLARITGSLSTVIGGALRGALMSAFPAAVPAAASLVGVVGSLGPMLGVAAGGAAGLGSAFATAGAGAVAYGALAATSIGGVIKASQDLDKLQAKLDDATDAKERAKIMEQIKNLQASLGKEERKALDTLEDFKSNWQDIAKSVQKPILRTFTTSLNTFKSVLNQLQPMFRGLARGGESLAKSMQNAFKAPDMKNFINYLNTEAPGAFVSFGKISGNIIRTVMNLMVAFGPLGKNMTKSIEGATAAWVKWSASLGSSVKFQKFIAYVQTNGPKLLKIIGNLSSGITSLFTGFAPLSADMMTSLVNLTARFKEWAASAKDSKEFKSFIDYIRTNGPIVWDSLGKIAKTLINLAVAMAPVGSEVLKMVNSFAQWTAATTKAHPEIGKFMAVAISLGGALRALTPVIISFQTLFGGFSSIGKAIDLIKKFKTSAAGIKLAAAIADMKLFTKTNALMAAQMAKTKFTNMITQLGLFGTKLRLQMSIMAAYLKQLVVAAAQQTAFAVKMAASYAQMKITSFITALKNGIIQMGLWIKNMAIMAAQSAANAVKMAAAWTAARISAFASMLAAGIKQMIAFGVRLAALAAAAAANAARMAASWVIAMGPIGWITAAVIALVALIIANWDKIKEYTVKIWGAVSKWLSDAWNKIKQAASVVWQALVTLIKKNFEMQKKIVTTVWNTIKSVSSKVWNGIKSFLSSVWNGIVNAGKTVWNGLKTFFTAWLNFQKKTWSTIWNAVKTAVTKVWKGIVSVGKTVWNGLKSFFTSWLNGQKKLFSTVWNAVKTAVTNVWNKLKSAASSTFNALKSSVTNIMNKVKDKIKSIWNSVMSFFKGINLGSIGRNIMQGLINGVTSMWGRVTSTFSRLTNAIPKTIKKILGIHSPSRLMRDEIGYHIGTGLVKGITGTEGMVTKAAASLAKSAVPEVPTVPELAVNSSYSGGMVEQSVNASLENFDLPEKNIIIQMDKREVGRAVEEPVREFTGRKRKRR
The following text describes a protein:
Function:
Possesses E3 ubiquitin-protein ligase activity in vitro when associated with the E2 enzyme UBC8 in vitro. Plays combinatory roles with AIRP2 in the positive regulation of the abscisic acid-mediated drought stress response.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing AIRP1 exhibit tolerance to severe drought stress.
Subcellular Localization:
Cytoplasm, cytosol.
Domain:
The RING-type zinc finger domain is required for E3 ligase activity.
Sequence:
MGCCCCLPSIPESSRTIDEHLPLSRATPSSLSNAYSSPLSPPIPLAITNINLQTSPPKLPRTQGNSSEASPGLTQVVPEKKTWHVDDLTDFELKKQYREAIDECPICLEEYEIDNPKLLTKCGHDFHLACILAWMERSEACPVCDKELVLTES
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MCSVSLSLWSQCFSPEKAQERLRVYEKRMCPPNLSFSQYLEALQSTGQAQCTTVWTKKTVAYRCRTCQVNDSSAICMGCFTRGQHVNHDYVMYHSESGGCCDCGYPEAWKPSGFCSAHRIGNRPESSVPADLERVSRLSVSSVLVMFSFIVSYIPETKGGPPVSTEKKIEVATIYLNWLKRLCSVDALRKIVCSEIVQRNAKDKEMREVKTPLQILMKTFASMPEDIMEGETTLFLQMLYDPKFKQQYSEELMDHYQMMLESVTEKIVRNDDPLVRHFKALDSSLDRVMVQLFNVPNLELIESKNLLRLFVMVLGKILKRCLARGTNVVNLRDPKIENKVYLRPQGDLRLVFAHQCVTQHLFEKQPDVFVSILDILVPLQWMNPYHPAKYVDFEENTEWTLGIQLEMHIMAIIFLLISGCYSIRRPDLEDPTETSRKTLLSAANCTLKRLREYLNEESTLKFLSSTAHSAPVSLHVPLHRTLSVVLAKLVLFPWKDVNDGFLSSLNLNYSEQEVLALMEHPLRIVVWTAQIRANRWTDVSGELNRLELIYRGSFWHDQSMDMDILLLQFCTVARENMERAAFMRMAERFELKELVSTPLNENEGEKFLLVHDFIKLVLLVVRERRNTGLEEMDCLRYDVIQWLCVKNQTYSQLCRALTATPVDDKKLREILDKVAYFHSPRIQEQGYFELKAECWQEFDPLFAHFYLNELEDAQERAVHIGKLPHYWRIRSLRGVKPPYNRLINLLHTEECHQLLWNVLNYVSALLMNVSTSTAGESLGVVALQMLGLALLDRRDNPEKFPVPAETLQSHPASSIDIFYNVYRRPQFNQNTRVMEWKICQSESPCILDLLRKLQDVTNAPRLVDSAHFVTQLLTASPYFVMGGVLPTKVALLPKAHDRVDTAHDDERLQKKQRQEAIMAQFKAKQNAFLEQFEVSDEDENDGPSFSDNNLESGSSSEDPSTEYSSIGTKSGKAAVKSSEIYECAFCRTECGGSDKSTGWIAFVQRYNMPKHVIEKRKEVNSKAHAEAIVQMANVSEYGNSSNGSDVKQLVVFMEENMIDQIPAEHVRCCGHQMHQECFQSYHASLVKSHCSEITYEGKDIIDLPKTEFLCPICRRLANVLLPIVHQPSLSKMLQFCVNDDLENQREHWVKFWDKCNNLRGALDHFAIQSLNVRYNFLKEVESKDLPKSPVFWEVFASNITHCEVETREKLPEVASSSAAMNQPSDQRLWGGDAGHWIAIRELGKLAMVFNTLDNGQEMTTKRETIKNMLTKISQFLQNEEISSQNEYLRILFTSVRSVLIRHLNIMEETLDPEELENCRRKEEFCQSNGTVEALHRPCTNGCTSLSMHRDSPHGQQRHPMRWTRSEPPRPEFFRRRGMDEGVAPCDDMETKGEDYVTTRIKGISCRMPPDPEYLDEPVLVPMDLDRSSFLQIGSLFNADPFRLLVVILSAFPGWPKAEEILLLVKFSYVVTLIQVLLACSGLEGNASINVLDLEKEWGGVVQHTCLPFLRRAALLVQITVGADCKQNYAGLGRSVMDASYLQRELGLAECHKMFFTSISEVDNFAATSGETSLLQQLRFDHNLLNKDSKLILMEVPKDLHFTTLPSVYQDLMLRSINEKCKECDSVPLNPAICLVCGVFFCFASECCTKENMEECSRHAESEGCGIGIFLFMHSTQLVLIRGGRVCMAHSIYLDQYGEGACGERQDESDSSDEPEDMLLRRCQLLHLSKLRLNEVRRLWLTAGFDSDTLILHNSRHSSRVL
The following text describes a protein:
Function:
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.
Subcellular Localization:
Nucleus.
Sequence:
MPSEPNQTRPTRVQPSTAAYPPPNLAEPLPCPRCNSTTTKFCYYNNYNLAQPRYYCKSCRRYWTQGGTLRDVPVGGGTRRSSSKRHRSFSTTATSSSSSSSVITTTTQEPATTEASQTKVTNLISGHGSFASLLGLGSGNGGLDYGFGYGYGLEEMSIGYLGDSSVGEIPVVDGCGGDTWQIGEIEGKSGGDSLIWPGLEISMQTNDVK
The following text describes a protein:
Function:
Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (By similarity). Required for pollen tube elongation and other polar growth.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Note=Localized in the GARP complex in the Golgi and post-Golgi compartments.
Sequence:
MSDISIDALGQTMGDFSNHEKLGFDLGAFVGDLAFEEDSGSEDISLEGLQQELEECESDEVVANILSSGDKLREYAKGVENNLRKVELDSIEDYIKESDNLVSLHDQIRDCDSILSQMETLLSGFQEEIGSISSDIKILQEKSMDMGLRLKNRRVAESKLAKFVEDIIVPPKMIDVIVDGEVNEEYMKTLEILSKKLKFVEADQAVKSSKALKDVEPELEKLRQKAISKVYDFIVQKLIALRKPKTNIQILQQSVLLKYKYIISFLKEHGKEVFMDVRAAYIDTMNKVLSAHFRAYIQALEKLQLDIATAYDLIGVETRTTGLFSRAREPLKNRSAVFALGDRIKIIKDIDQPALIPHIAEASSLKYPYEVLFRSLHKLLMDTATSEYMFCDDFFGEESIFYEIFAGPFSVIDEHFNPVLSNCFDAIGLMLMIRIIHHHQLIMSRRRIPCLDSYLDKVNISLWPRFKMVFDSHLSSLRDANIKTLWEDDVHPHYVMRRYAEFTASFIHLNVEYGDGQLDINLERLRMAVDGLILKLAKLFPRPKQQIVFLINNYDMTIAVLKEAGPEGGKIQMHFEEMLKSNTSLFVEELLVEHFSDLIKFVKNRASEDSSLNPERSITIAEVEPLVKDFGSRWKTAIELMDKDIITSFSNFLCGMDILRAALTQLLLYYTRLTDCIKKIDGGSALNRDLVSIQSIMYEIRKYSKTF
The following text describes a protein:
Function:
Catalyzes the reduction of tatronate semialdehyde to D-glycerate.
Sequence:
MKVGFIGLGIMGKPMSKNLLKAGYSLVVADRNPEAIADVIAAGAETASTAKAIAEQCDVIITMLPNSPHVKEVALGENGIIEGAKPGTVLIDMSSIAPLASREISEALKAKGIDMLDAPVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVHTGEIGAGNVTKLANQVIVALNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIKDLANALDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHSALACYYEKLAKVEVTR
The following text describes a protein:
Function:
Component of the spliceosome involved in mRNA processing.
Miscellaneous:
MISCELLANEOUS: Present with 1310 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MRGEWQEFKTPAGKKYYYNKNTKQSRWEKPNLKKGSNLESNAKESQTERKPTFSLELVNGWHLIIYNDGTKLYFNDDSKEFKNDISQEDDSRCRSLIESLDKEKLVLLIGVARGYTMREEDIDKILESCNEEIHLFKRNQDEVERKDEISEEAGDVKSPLQESHTGLVSGYGSSSGEEDEEEDEEEDEENEEQIVNQDISIIDDLNRIDTDDIDERNIFFELFDRYKLDKFSTWSLQSKKIENDPDFYKIRDDTVRESLFEEWCGERSGNATAEESDSEDNSEDDSEVLEPTKYHYLAQIVANAGTIAPDTIPQDIRKQQKALYKAYKIKEYIPSKRDQDKFVSQLLFYYKTFDLEQRKEIFCDCLRDHERDFTGAVESLRQDKELIDRWQTLLKAPADSSSIEDILLSIEHRCCVSPIVVTEPRYYVVGILEKTVVWVRWLAAEVGPSSRFTPVGAGNEPINPE
The following text describes a protein:
Function:
Responsible for microtubule translocation. May be important for the organization of phragmoplast-specific arrays of microtubules. Plays an essential role in stabilizing the mitotic spindle. Required during mitotic cytokinesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
METPKLNHQRRGSIPPFLMSQTLWSNEKLCRDSRSNDEKGVNVKVILRCRPQNEDEMKVKGPSVISCNDLKKEVTANLNTATKQLNKTFVFDKVCGPSSQQKDFYDHSVAPLVNEALEGYTCTIFAYGQTGTGKTYTMEGEAIKEKNGEFHKNAGVIPRAVQQIFDILETQKAEYSMKVAYIEIYNEEITDLLSLDEESKSIDEKPRKPLALMEDGKGAVFIRGLEEVTVSTADEIYKILEKGSANKHTAETLLNKQSNRSHSIFSITLQVKECTPEGLELIKCGKLNLVDLAGSENILRSGAKEGRAREAGEINKSLLTLGRVINALVDHSGHVPYRDSKLTRLLRDSLGGKTKTCIIATVSPSIQCLEETLSTLEYANRAKQIKNRPEVNQKVTKSALIKDLYVEMDRLKQELHATREKNGIYIPQDRYLSEEAAHKAIFERLKFLELDLESKNKKLRELQDLYDYQRQLTADLTKKLERTQRELKEAEQAFNDLQAQNSRAKETVQEKDHLVSNLIKSEKAMTDKALELRAEVENAESEISTLFAKTEKTNNREERNKILVQNFRNKLTQQLESLKRNTAVSVTKQEQQLNVILEDTQSFLATKRRGTDELKSQLQKLKDKYSSDIQNLAISAQELNENSQLAFSEVHSEVSKHSSFFMVFVAKISADVNAILNGLQGNITELEVKISAFVQKEQQNQTRRYQGIQLTSEVLLNFFKTLNSYISKLRLMDEKSQTINHQQLCTLEEKFEELAASEERQLIEKVAELMSASNTRKKRLVQTAVNGLRECSSIKTRNLNAEFSNIQGCTNSAYEEWTSYVESTQAHHIEDSTRLEFWKSSLAGHVECCLAKSKGVQDGWRNAEESLLRQQTRNINSIDCIMKSAMESNGKTSTQFSSTVTSILEETAISKRNLLSAMESLLKLDHNECEKIYSFIHPCVEDMKQMKDSHSSKVSEIAENAGKVLTDEYKVDEPSCSTLRRKRVSVPSRESIENLRTPLLEESLKSFQGNVIAKRANRM
The following text describes a protein:
Function:
Peroxisomal adenine nucleotide transporter catalyzing the counterexchange of ATP with AMP. ATP is needed by reactions that generate acyl-CoA for peroxisomal fatty acid beta-oxidation during postgerminative growth. Required for the beta-oxidation reactions involved in auxin biosynthesis and for the conversion of seed-reserved triacylglycerols into sucrose that is necessary for growth before the onset of photosynthesis.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MGVDLESLAEATSGAVGSLLSTTILYPLDTCKTKYQAEGQAHGQQRYRHLSDVLWEAISNGQVLSLYQGLGTKNLQSFIAQFVYFYGYSNFKRLYLKRTGYKSVGTSANLVLAAAAGACTAIITQPLDTAAARMQTSAFGKSKGLWQTLTEGDWTHAFDGLGISLLLTSNPAIQYTVFDQLKLRLLKGKQNKTDKGSSPESLSAFSAFALGALSKSIATILTYPAIRCKVMIQAVDSSENGTETAKKKPRKTIPGIMLAIWNREGFLGFFKGLRAQILKTVLSSALLLMIKEKISATTWVLMLALRRSLLLTRGGLKSA
The following text describes a protein:
Function:
Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore.
Miscellaneous:
MISCELLANEOUS: Present with 45300 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MKSFITRNKTAILATVAATGTAIGAYYYYNQLQQQQQRGKKNTINKDEKKDTKDSQKETEGAKKSTAPSNPPIYPVSSNGEPDFSNKANFTAEEKDKYALALKDKGNQFFRNKKYDDAIKYYNWALELKEDPVFYSNLSACYVSVGDLKKVVEMSTKALELKPDYSKVLLRRASANEGLGKFADAMFDLSVLSLNGDFNDASIEPMLERNLNKQAMSKLKEKFGDIDTATATPTELSTQPAKERKDKQENLPSVTSMASFFGIFKPELTFANYDESNEADKELMNGLSNLYKRSPESYDKADESFTKAARLFEEQLDKNNEDEKLKEKLAISLEHTGIFKFLKNDPLGAHEDIKKAIELFPRVNSYIYMALIMADRNDSTEYYNYFDKALKLDSNNSSVYYHRGQMNFILQNYDQAGKDFDKAKELDPENIFPYIQLACLAYRENKFDDCETLFSEAKRKFPEAPEVPNFFAEILTDKNDFDKALKQYDLAIELENKLDGIYVGIAPLVGKATLLTRNPTVENFIEATNLLEKASKLDPRSEQAKIGLAQMKLQQEDIDEAITLFEESADLARTMEEKLQAITFAEAAKVQQRIRSDPVLAKKIQETLAKLREQGLM
The following text describes a protein:
Function:
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular Localization:
Nucleus.
Sequence:
QRLQAFWTDRLDEIEHMSDFKIHSLPLERIKKIMKASGENVQVIAGEAPGVLTKACEIFIQELTLRSWLQTREKNRRTLQKNDIAAAVSRNEAFDFLVDIMQDNGVGLPTGTMQTMIPGMGTFGIGGQDE
The following text describes a protein:
Function:
DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro. Acts as an AR-coregulator in Sertoli cells.
Subcellular Localization:
Nucleus. Note=Localizes in speckle-like nuclear compartments.
Domain:
Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be important for the association with nuclear receptors.
Sequence:
MSDESASGSDPDLDPDVELEDEEEEEEEEEVAVEEHDRDDEEGLLDDTSLEGMCGTEHAQLGEDGQRPPRCTSTTSSQSEPSEQLRHQGKILASEDPKKKRAQKPSHMRRNIRKLLREDQLEPVTKAAQQEELERRKRLEQQRKEYAAPIPTVPLEFLPEEIVLRASDGPQLPPRVLAQEVICLDSSSGSEDEKSSRDEVIELSSGEEDTLHIVDSSESVSEEDEEEEKGGTHVNDALNQHDALGRVLVNLNHPPEEENVFLAPQLARAVKPHQIGGIRFLYDNLVESLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWLPAPEALPADSKPEEVQPRFFKVHILNDEHKTVASRAKVTADWVSEGGVLLMGYEMYRLLTLKKSLATSRPKKTKKRSHPVIIDLDEEDRQQEFRREFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILVRLSQIQRDLYTQFMDRFRDCGTSGWLGLNPLKAFCVCCKIWNHPDVLYEALQKENLANEQDLDVEELGSAGTSARCPPHGTKVKGEDSALPSSMGEATNSKFLQGVGFNPFQERGNNIVTYEWAKELLTNYQTGVLENSPKMVLLFHLIEESVKLGDKILVFSQSLSTLALIEEFLGKRDMPCLPGAEGQGTQKWVRNVSYFRLDGSTPAFERERLINQFNDPSNLTTWLFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQKKPCHIYRLVADYTLEKKIYDRQISKQGMSDRVVDDLNPMLNFTRKEVENLLHFVEKEPAPQTSLDIKGIKESVLQLACLKYPHLITKEPFEHESLLLNRKDHKLTKAEKKAAKKSYEEDKRTSVPYTRPSYAQYYPASDQSLTSIPAFSQRNWQPTLKGDEKPVASVRPVQSTPIPMMPRHVPLSGGVSSASSTNTSMNFPINYLQRAGVLVQKVVTTTDIVIPGLNSSTDVQARINAGESIHIIRGTKGTYIRTSDGRIFAVRATGKPKAPEDGRMAASGSQGPSLASTSNGRHSASSPKAPDPEGLARPVSPDSPEIISELQQYADVAAARESRQSSPSISAALPGPPGQLMDNSTIPGTALGTEPCLGGHCLNSSLLVTGQPSGGRHPVLDLRGHKRKLATPSVTQESIRRRSRKGHLPAPVQPYEHGYPVSGGFAMPPVSLNHNLTTPFTSQAGENSLFMGSNPSYYQLSNLLADARLVFPVTTDPLVPAGPVSSSSTATSVTASNPSFMLNPSVPGMLPSYSLPFSQPLLSEPRMFAPFPSPGLPSNLSRGVSVYPGYMSPHAGYPAGGLLRSQVPPFDSHEVAEVGFSSNDDEDKDDDVIEVTGK
The following text describes a protein:
Function:
Cilium-specific protein required for cilia structures in Johnston's sensory organ. Plays a role in motility of cilia and flagella.
Subcellular Localization:
Cytoplasm. Cell projection, dendrite. Cell projection, cilium, flagellum. Note=Detected in the inner and outer dendritic segment and basal body.
Sequence:
MVLITEELVRKKSEHNERLISTLEEISLHQEDIEVIEHIQNWCRDLKILLLQSNLIARLENLHKLKRLEYLNVAINNIERVENLEGCESLSKLDLTLNFIRELTSVESLCGNYNLRELVLIGNPCVDYPHYRDYVVATLPQLNSLDCVEITPSERLRALRELSKNRSIIVQKQVEQDIERDEQRIRVAKQQSALAEHCAGIEDEEERIKAFWQAKSEHCPEIRTEIARQHRLGRERHETKSPLDPLKPQRNLFAPCGRPYNLNQAKLPFKFRDEADHYLLQLEVYRHLDTSLIDVDVQTTYTRVTVKKKIFQIAYSEEVKPDESTVQRSQITGHLVVNLKKLKVNELLIAKKSPTKSPAAPFDAGKKDGKPEEAFHGGVVDISNICAPEDLPDLI
The following text describes a protein:
Function:
Effector that promotes P.infestans virulence and suppresses pattern-triggered immunity (PTI). Interacts with the host ubiquitin E3 ligase NRL1 and enhances the association between NRL1 and SWAP70 to promote proteasome-mediated degradation of SWAP70, which results in the suppression of immunity.
Subcellular Localization:
Secreted. Host cytoplasm. Host nucleus, host nucleoplasm. Note=The cytoplasmic localization is more important for its contribution to virulence than the nucleoplasmic localization.
Domain:
The RxLR-dEER motif acts to carry the protein into the host cell cytoplasm through binding to cell surface phosphatidylinositol-3-phosphate; The C-terminus (residues 126 to 135) is required for the interaction with host NRL1 and the ability to enhance the association of NRL1 with SWAP70.
Sequence:
MRLAFLLLAVSHFICGNALPTNVKSSPVVSPGLIQSFDNAQKPVVMSRKLLRTDERLSEANEERTKLSELFRLDDDEVAAIKELSSMFSAFLQKKSQAFDVYDEIFRSGYPIDTAARISNLYTKYLKDPQAFRGP
The following text describes a protein:
Function:
Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. In addition to its role in regulation of the mTORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux. Within the GATOR2 complex, WDR24 constitutes the catalytic subunit that mediates 'Lys-6'-linked ubiquitination of NPRL2.
Sequence:
MDFRVVDFVRNETKIFTDSDLNMEPPGNSNMALAKYTTSVNVGSAINALSLCQNSNKIVVAGRALLKIYEAEPQNQLKEIANLHMGRKQGLNMSSSDVVWSSKDENLIATAATNGAIVVWDLNAVGRNKQLAVLSDHRRTVTKISIHPKESTRLLSGSQDCTMRMFDLRKKESTGMFQSKADGVRSVEFSPFHYFMFAASFDNGSVQQIWDYRQSKTYLSQFLAHKGSVYTLNWHPDEDERNKIATGGRDNIVKVWETGTSHNKQISNIPTSTSVSAVRWRPSHKDQLATVSMMLDFSVNVWDLRRRFVPYAYFEEHNDVTTGIAWKQNDPEVLFSCSKDGTLVMHAMQDAIQPWKKIKTRGLDVGSRGLVLFAGEDSNIPARAQSPTGSGQNKLPGLFGWGVGKQDPEWAGSAPASPTTMDEIISETFVDDGFVYAAKHYLLNGPENDMSFRKLCEHNSNVAAKLGEFSVSRVWLILAEFYNSVVLLKQKMTSNFFPVPKTCSDATLDGTKRTENETKRNSVIRLQNTVVILLESLSVTFIQVEDYLTDIARGRHSEPDFYISDDENGLWGGATSDADFMYTQEWSLMGRVPTEAFEKSHIDAPSGMTNDSEAPKQKIITPHGGRWYETQTSTQDSSSPPTPTSMDQNSDPLATAFHVNVTIFTLTRYLAESGDVQTPVSILVAISSYPTNVTLEIPEAEAEHWFNSYLDLLFKHELFVQHAEVIKLSRLPSIRMLSSSSTIHTSCKVCQRRMPNSCSWSCDHRSKPDHKSPVLCFLCKKVVKTLYLYCQTCSFGGHLQCMQSW
The following text describes a protein:
Function:
Catalyzes the conversion of L-glutamate to alpha-N-acetyl-L-glutamate. L-glutamine is a significantly better substrate compared to L-glutamate.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MTERPRDCRPVVRRARTSDVPAIKQLVDTYAGKILLEKNLVTLYEAVQEFWVAEHPDLYGKVVGCGALHVLWSDLGEIRTVAVDPAMTGHGIGHAIVDRLLQVARDLQLQRVFVLTFETEFFARHGFTEIEGTPVTAEVFDEMCRSYDIGVAEFLDLSYVKPNILGNSRMLLVL
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MEAAATIITAVVILCWLQFSSVECHWRLRNPRQPNQTEASTRPQGTLLQSNDKLQDRFYRNTCPQAENIIAKSVYDAVLVQPGLAAGLIRLHFHDCFVNGCDASILLDTTPSGEPVEKTSRANVFASQIFKYIDRLKADIERECPGVVSCADILAYATREAVKEEGLPYYLVPGGRRDGLSSSASNVAGNIPSPNESLKNMTQIFLTKGLSIEDMVVLFGAHSIGHTRCRSLFKRLYNYSSTQAQDPSMDFAHSLYLKGLCPKAGPLLQEVIDKVMVPLEPITPSRLDTLYYTQLLKGEGVLQSDQALTNNPTTNEIVKRFSQNPLEWGARFTNAMINLGKVDVLTGQEGEIRRNCRAVN
The following text describes a protein:
Function:
Auxiliary protein of electrogenic Na(+)-coupled sugar symporter SLC5A2/SGLT2 and SLC5A1/SGLT1. Essential for the transporter activity of SLC5A2/SGLT2 but not SLC5A1/SGLT1.
Subcellular Localization:
Apical cell membrane; Single-pass membrane protein.
Sequence:
MSALSLLILGLLTAVPPASCQQGLGNLQPWMQGLIAVAVFLVLVAIAFAVNHFWCQEEPEPAHMILTVGNKADGVLVGTDGRYSSMAASFRSSEHENAYENVPEEEGKVRSTPM
The following text describes a protein:
Function:
Male seminal protein which enhances ovulation in female Drosophila by stimulating the release of oocytes by the ovary following mating. Acts by increasing octopamine (OA) neuronal signaling in the female genital tract leading to the postmating relaxation of the oviduct muscles. This activation of the OA signaling pathway is likely to indirectly contribute to the mating-dependent increase in the number of OA synaptic sites in the female reproductive tract; [CP3-N]: Male seminal peptide which is able to enhance ovulation in female Drosophila; [CP3-C]: Male seminal peptide which is able to enhance ovulation in female Drosophila.
Subcellular Localization:
Secreted. Cytoplasm. Note=In 1 day old virgin males, secreted into the cytoplasm of accessory gland cells. In 5 day old males it localizes to cytoplasmic vesicles of the secondary cells.
Sequence:
MNQILLCSPILLLLFTVASCDSEQQLDSAMHLKSDSTKSASLKNVAPKNDETQAKIAKDDVALKDAKKGDYIMDIDISDLPLDDYPINRSKSLKSSSIDLNNIPFNKGLDDFPAKEKNQGSNQSALKALQQRLLTEQNNSLLLRNHSIYLMKEIEARKTDIIKVRQLNLDLELELNTVNRRLLELNGQLQNTRKSTKPCKKRSSKDSAPPAANQFQEANVRNTYRNKYLTLLKELSQKINNEIAKVATDVPTETNPSQGNLPTL
The following text describes a protein:
Function:
Plays a role during cell aggregation and slug migration.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MLTNNEIYQEVQKFAKGYDLNQDGVLTSQEIYYSLLKKMNGNSYEASKATGVLCSTIDINKDGKFSYHEIAKYCADNAKKLIEQNADIAALADVEAFLLRFDKDKDRKLNKTEFVEYFKGGTDTPYSDRDYVLKIIDLDKDGCVSANELQEWFKKKRIDYASRPHC
The following text describes a protein:
Function:
Component of the RAVE complex which is required for stable assembly of the vacuolar ATPase complex V-ATPase.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQTEIDASVIVKEKEWLETNVLPEFWESMSEGLKEALNLISSDDPTVLVFTSPKTDAVKGIVSRSSSNVVRVNVTAKVGRTTHVLKLKDSAIIHLDQILNLSNYMHYALYCLPRLRHNTERAIKELQEILHAIVCLLHSIMQEESEKEEIPSNASSISLKSQNSIVSRTSNPFSCLNHSPRQIHKTVRNHLFSPPLPSNLALSFSISNASVCLHLFRLSGPNEVLESFAKNSVDIEMLKPFVSQRIDAFSQDPILLAVTAKLSALQKKVNDVSYRFKTISSSLYGAK
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MVGEDDVSSNNAPINNLARALLENHEPKFVAAEDSLQDLTAKQDMLMGQVFRQTDCLSEAIKHTQVYEMVTQTKIYQNKLLSLQKEMADLSERSQKIKKRALKLQQSKQHEALLREQAKDRELEREKQLIARPAKRN