lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription; E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSFAVNTFQKYSNDFGLGSNGVKVTLNYFDALPPQDLLMSLPSGLQLTLKSLLKRDDTTKERALNEIQELISTQASAEQFKDDIFCLCWSQIYAKLVTNSSKSIRAGTHDFTARLIRLLHKKGAKFLKDWIPLLLVGCYDIDTSVGSSARSALLQCFNNSDEKLAALWKVFYKQILACAQQILVVENVGSISDERYVSPEDADMRYSRLAASGVFLLVQLLKNMNDEQGEEDTWYEILSSEALWKLMSLANLRSMKLYQVLLQLQRILLENGYLLGHKDVLKLTGKRYFKTLAQVNTRNLLQISPLLPEVLETTLLWNSYKDGQIWAYDKSFKDRILNLLKLGPGNSSAAYFDYLSKLFRVCEFLNAEETKLSILHKHALVFSERRILTKTSEEQLSRFCSCYYQIVREIDSEVARDQMRDDSQKLISNISLQKHSNLVEAFAQITSPDSISTDLCSLLPLGTDKEHPSTTYADNLLALLLHNGLQKVDILKELARSSLESIENGEVAVNYSFRIFQLFIKNNILSLHQEVQKFIGILPSTIDPSFIEQPTNIMSSYSRSQFLQQMGEEEAVELFSDYVFAIAQLDIPMNSKLTHLNNLDIAILEKLRKEPSETLADFMTNFIGTYDFSTDLIFSSNLLDQHVLKRLYEKALEHRKLDVFSSYLTRVPLTIYEEFLCGTDFLSNYNIWYSAAAAQQVLKSLIPMVKRNGSFARKVTQEIVVHGASDYKHIPTELLIKFASELFESNSDIWSYLSPHIMLKDLKTIVPYIDYRLSLVSPLGVGIHALDIPNESTFECSSARSIISYALFLDKFLTNHPQLCDDDCRIFLALMSELTLDFNCFSTDPIDQFPGFTNSLFTGKTYDFNFADIVHAIIAGESHIAILNKLASRDVSDSSAVYNCRILKRMLLNSIDYTTLNQFNEQVRIEKFISGIIRNTSSSAMDYLYATTIISACSKFSAESPMFVKLRTMLVAELIGKNSTDLVNGSWRLLILLDNILQVETSIMHSDSFQPITPQRLVMFVRTIFQWLDSDVCFEESFSVVRLCLLHLLISMLQINSIRSLGSSLTDLCIRILADSLGFCHLEETLYLDELRFYVLKLHLEIIRWTKEDKNTKDLWEHSAKDLNSELVELCLINYEKTPENHPHILFCSLLSSSVDQIPESYLQSYFDKFMEYLLSSLGTISSVRVVVTTLRKLIIAQQQELVIEYELQKSNLGDGDNTPTSTCKIPPILVSALFADLPEEYLEYEEPMKVIKPLWYWYLVVSYFKNISYNIRHQYIDQLKANNEIDRFFYFVSEQLDMQDTKFWDSVSPHEITEYQIHATGDSPYKDDILKESKLLLVSLLYDLFNNVGAMTSAWWLNIKDRALRSKIDAFVTRYVSPILIDQELEQVSSKIPVLTAQDENLSIRINKITKEIKARYFIDDQNLEISFKLPCNYPLTNIQVQEGTRVGVSEQKWKSWILSTQRVITGMNGSVVDSLELFTKNVRLQFADFEECAICYSILHVVDRKLPSKVCPTCSNRFHGACLYKWFKSSGNNTCPLCRGEIPFRR
The following text describes a protein:
Function:
Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MLLRSLRSWAARSPRSVGPGSSGSPGSLDSGAGPLWAPRRAWPPDKDRENDKEKKAVVCIEGNIASGKTTCLEFFSNTTDVEVLMEPVLKWRNVHGHNPLSLMYHDASRWGLTLQTYVQLTMLDQHTRPQMSPVRLMERSIYSARYIFVENLYRGGKMPEVDYAILSEWFDWIVRNIDVSVDLIVYLRTTPEICYQRLKMRCREEEKVIPMEYLHAIHRLYEEWLVNGSLFPAAAPVLVIEADHNLEKMLELFEQNRARILTPENWKHGP
The following text describes a protein:
Function:
2-oxoglutarate-dependent dioxygenase involved in the oxidation of jasmonate (JA), a stress-induced phytohormone synthesized in response to attack by pathogens and herbivores, which triggers the activation of defense responses via the JA-mediated signaling pathway. Converts JA to 12-hydroxyjasmonate (12OH-JA), an inactive form of JA. Is specific to free JA, and cannot oxidize the bioactive form jasmonoyl-L-isoleucine (JA-Ile) or other JA-amino acid conjugates. Prevents over-accumulation of JA and indirectly its bioactive form JA-Ile under stress response. Acts as a negative regulator of JA-mediated defense signaling, by contributing to 12OH-JA accumulation, which represses JA defense responses upon infection by the fungal pathogen Botrytis cinerea. Acts as a negative regulator of JA-mediated defense responses upon infestation by the herbivorous caterpillar Mamestra brassicae.
Sequence:
MATCWPEPIVSVQSLSQTGVPTVPNRYVKPAHQRPVFNTTQSDAGIEIPVLDMNDVWGKPEGLRLVRSACEEWGFFQMVNHGVTHSLMERVRGAWREFFELPLEEKRKYANSPDTYEGYGSRLGVVKDAKLDWSDYFFLNYLPSSIRNPSKWPSQPPKIRELIEKYGEEVRKLCERLTETLSESLGLKPNKLMQALGGGDKVGASLRTNFYPKCPQPQLTLGLSSHSDPGGITILLPDEKVAGLQVRRGDGWVTIKSVPNALIVNIGDQLQILSNGIYKSVEHQVIVNSGMERVSLAFFYNPRSDIPVGPIEELVTANRPALYKPIRFDEYRSLIRQKGPCGKNQVDSLLLTR
The following text describes a protein:
Function:
Catalyzes the biosynthesis of ceramide phosphoethanolamine (CPE) through the transfer of a phosphatidyl head group from cytidine 5'-diphosphate (CDP)-ethanolamine on to the primary hydroxyl of ceramide.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Golgi apparatus membrane. Cell membrane. Note=The majority of protein localizes to the Golgi apparatus.
Sequence:
MIGPSSQISKILLTLLFLLIIFYVFMDVELYLRIHNYAIERNYHTNVSLPASVVGPSTSESGSGSIGGSSSSSSSSSSSTSTKLPTAGDRQPSYEDHTWISCDINPLCHVTVKAILLDHTNHYLFAPLATMFDNVIGFSRSTFITPNMISFFHVGVACLAGKLVASDSLGYRRLGVLLFQIRTFLDDLDGHVARVRKHIRGERSEIGTSGYYVDGLCDGLGCIALLLGIFFYLKNNPPRRGYSIIPMSDSKLPEPTMMIPKMKATTRKVAKNVISFTGQLLLSSTAWNRYIAVYQNMLEREDVSGNQSHCQDYVFKSTWFFCVAWMWRIVNVHALLHCVLLSIFCDKLWDFLRAIRYSGYIILLVAICLTEMHILEAQNYIFNSTACSNISL
The following text describes a protein:
Function:
Plays a role in axon pruning in larval mushroom body neurons during metamorphosis. Plays a role in the infiltration of glial cell processes into mushroom body lobes and the subsequent engulfment of degenerating axon branches. Involved in Drpr-mediated phagocytosis of apoptotic cells. Required for bacterial phagocytosis. During neuromuscular junction development, required for the clearance of pruned ghost boutons and presynaptic debris and for normal synaptic growth.
Subcellular Localization:
Cytoplasm.
Sequence:
MPYQPANSGGTSGGSKAAAKMAQLKFWNKQNSSKQQQQDKDKDAADGGNNTSGGGTGSNSNGDAKSEAKNGKRNWLHTPEQLISGHAVYLVKFFGNLSVDQPKGIEVVKEAIRKLQFAQQMKKAETGTQEKFKKLEITISIKGVAIQEPRTHKILHQFPLYNISYCADEKGVKKFFSFIAKTVKTQDGSDPTSNGHANGNGDGSAKVEESHECFVFISNKLASDITLTIGQAFDLAYRKYMDSTEKTNLSKAQQQINHLQQTVNVYKERLREVSAKLPKAELDALLFNLGIKDILEAPTTEPQNGIEVASEALSNGKLDDDKLLIDTNSTTASTHSASPSSFLPIVPPRNNLSSQISIGGKSNSQKMDELLLNSDSDSDFDPRADETQEIGGTGRSAISNMFGFEPANSFGQHLFSNNNDHKLQNNNSSLLITSNNNSINSSGFSSELNITPPLLAPPPKIAAPRRLNSVTTGNGLNGNTDLFGSDPFELNNGPNIFKQNQLNLDDFSLESLDPLRK
The following text describes a protein:
Function:
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
Sequence:
MIRIGNVTIPGKISLSPMAGISDSPTRRICRKFGAAFSYTEFVNTDELVHRAPKALKMFRYKSEERPITFQIFGNRLEIIAEAAEIIQELKPDIIDLNMGCSTRKVSLRGAGAGLLRRPLLAGKIIEAIKKRVNIPVTAKIRIGWDSTSRNYLEVSKILEESGVDALTVHGRTKEMAYTGFADWDAIGEIKVNRKIPIFGNGDIKSFQEANFKIDKYLLDGVLIGRNAIGNPWIFSGVKKEELSWSEVLDVILQHLRWMIEDYGEEFGLVLFRKHLVKYLNGLEFDLAWKTELLEIKEWNRFEDILLSDKKRIEFTVPTFGTTKRFVFP
The following text describes a protein:
Function:
Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle. Presynapse.
Sequence:
MTYQAQLFQCCREGDLQKAQFLHEEKDVDLNLRDIWDSSPLYYACLCGHFELVEYLLQNGAKCVENSFDGERCLYGALTNDIKNLIKNWKQVHTRGLRRERHYDMMRSLLDKGSFYDVIMNVHGRQFKVHRYILSARSEYFADAFSNKWKNVDEVNISHHAVTADAFACLLQYLYTGRMDIQCDMVGQVKRLAKNCRLDLLHQEIIKVELRVDELVRLKPQMKKRVKVFSIEGEVCMSVFRDDLRKLVDHVIPPSLHDWVEDGILPFTKMWRETLLFPDVCFNIDNHLFLGHKAIFCACSDYFTALFEDHFLENSFHSGTRVLPMITLTHISPQIFKNVVVSMYSDEVEFTSMDTAYETMCTSHMLLFHGLTRRCGQILGQHLDESNLFPLLEVARNFDLPKLEDMCAMYMAKRNNVLNKMHD
The following text describes a protein:
Function:
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Has an essential role in mediating growth by negatively regulating insulin signaling. It also has a role in maintaining presynaptic function in the neuromuscular junction synapses of third-instar larvae.
Sequence:
MDEGDIGAVDDSHALVVLPLENNVADEGPRNELLQMQRIRELDMEPLEEEADSEAGHSLSYNDSSSGGRGDGGGGQMGGFTFDTNLASMHTYLGEVDDVHSSRSFADGGALLTLPMFYLEGIVLFPEDTLPLRVLQPRFKAAVDRAMRNDEALNTIGVIHVRARDGHVHVASIGTTAEIRQLRHLTDGSINVVTKGRQRFRVCKAWTEADGALFAQVQIIEEKIPLHVPRDAFSHLAAVSAFHSGKVPRAATTSSLLHEQSDDEAGLQADVDGSDDFESDSGPEARLLRRLTRFASESTELLRALERVVGEDESSERERLRWWFRRRRVRRRSFDDFEVGNDRGEEPESSGELRLGDALHSNERRVYPGEPSGISNGHSTSVKRPPEGGRGGCWKAWAADAGKWRCKAQRSAWPYWVYRQFDAYDLARRAADMLRQMAELPRVEAMVRTPSLLSYYIASNMPLQDATRQELLEVDGTVYRLRREIELLESMDQLRCKRCLDIKARRSEMLVMSAEGPISAYVNAHGYVHETLTLQRACRLVLAGQPQTANSWFPGYAWALAECSACTEHMGWRFTAVAKETRPKAFWGIRRFFLFFFSSFSFLFSNLPSSCGSATVHELKNLLRPLKPGAWSH
The following text describes a protein:
Function:
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MGLLILFLSKVEALSGQVCLWDPHRRRCCCPGWPGAPRRHAEAGSRKMSRLLLGGTLERICKAVLLLCLLHFLIAVILYFDVYAQHLDFFSRFGTRGSAARPHPGANCSRPNGTAPSPGTPESPSGRPDANRSVTVLPLPPCPEMPPGLVGRLLIEFSSPMPMERVQRENPGVTAGGRYAPPDCTPHQTVAIIIPFRHREHHLRYWLHYLHPILRRQRLRYGIYVINQHGEDTFNRAKLLNVGFLEALKEDGEYNCFIFSDVDLVPMDDRNLYRCSEQPRHFAIAMDKFGFRLPYAGYFGGVSGLSKSQFLKINGFPNEYWGWGGEDDDIFNRISLSGMKVSRPDSRIGRYRMIKHERDKHNEPNPQRFTKIQNTKLTMKRDGIASVQYRVLEVARCPLYTNITVDIGKAPPRPARG
The following text describes a protein:
Function:
Required for incorporation of 9(10),16-dihydroxy-hexadecanoic acid into cutin.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MKIKIMSKTHVKPTKPVLGKKQFHLTTFDLPYLAFYYNQKFLLYKFQNLLDLEEPTFQNEVVENLKDGLGLVLEDFYQLAGKLAKDDEGVFRVEYDAEDSEINGVEFSVAHAADVTVDDLTAEDGTAKFKELVPYNGILNLEGLSRPLLAVQVTKLKDGLAMGLAFNHAVLDGTSTWHFMSSWAEICRGAQSISTQPFLDRSKARDTRVKLDLTAPKDPNETSNGEDAANPTVEPPQLVEKIFRFSDFAVHTIKSRANSVIPSDSSKPFSTFQSLTSHIWRHVTLARGLKPEDITIFTVFADCRRRVDPPMPEEYFGNLIQAIFTGTAAGLLAAHGPEFGASVIQKAIAAHDASVIDARNDEWEKSPKIFQFKDAGVNCVAVGSSPRFRVYEVDFGFGKPETVRSGSNNRFNGMMYLYQGKAGGISIDVEITLEASVMEKLVKSKEFLLSEEEEEDDGKKLTNGNGHVNGNGNGYVNGNGNGFV
The following text describes a protein:
Function:
Probable oxidoreductase that may play a role as regulator of mitochondrial function.
Subcellular Localization:
Mitochondrion matrix. Note=The import into mitochondria is dependent on TOMM40 and TIMM23.
Sequence:
MAASGRGLSRALHSTPCPAWKRVQSGANGCLKPEYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIIPGFKFSRASYLLSLLRPQIYTDLELKKHGLKLHLRNPYSFTPMLEEGTLSKPPRSLLLGTDVAENQKQISQFSRKDAQAFPRYEEFMKRLVLAIDPLLDAAPVDIAALQHGSLLQRLRALSTLRPLLKAGRTLGAQLPQYYEVLTAPISKVLDQWFESEPLKATLATDAVIGAMTSPHTPGSGYVLLHHVMGSLEGMQGAWSYVQGGMGALSDAIASSATAHGASIFTEKTVAKVQVNSEGRVQGVVLQGGEEVRSRVVLSCASPQVTFLELTPQEWLPGAFVKRISQLDTQSPVTKINVAVDRLPNFQAAPNAPGDQPQAHHQCSIHLNCEDTLLLHQAFEDAKGGLPSQRPMIELCIPSSLDPTLAPTGCHVVSLFTQYTPYTLAGGKVWDEQKKNTYADKVFDCIEAYAPGFKRSVLGRDILTPQDLERIFGLPGGNIFHGAMSLDQLYFARPVPQHSDYRCPVQGLYLCGSGAHPGGGVMGAAGRNAAHIVFRDLKNM
The following text describes a protein:
Function:
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on target proteins.
Sequence:
MEFLGAHLAFRFRWHKTDEELCRHSMSFVLHKAISTDFFESYLYLFERQPLVNLYALTSEVIDGEMQFYARAKNFYRDVPATEEGMMGGFSELTNIDTESSREFLRKFVGGPGKAGTDFALDCGSGIGRLSKNVLLPVFSNIELVDMMEPFLEEAQNYLEEEVDRVETLYCYSLQDFFPPVRTYDVIWMQWVSGYLTDKDLQEFLIRSKNGLKDNGVIILKDNVARQGCILDPTDSSVIRDIHILRNIIEKSGMSILAVERQSGFPELCIPIWMIAIQ
The following text describes a protein:
Function:
Involved in post-transcriptional regulation of gene expression. Promotes mRNA stabilization by recruiting a complex containing PBP1, LSM12 and XAC1 to mRNAs. Recruited to mRNAs by sequence-specific RNA binding proteins. May regulate translation through interactions with the EIF4E6-EIF4G5 translation initiation complex.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, Stress granule. Note=Localizes to polysomes. Partially localizes to starvation-induced stress granules but not to heat shock-induced stress granules.
Sequence:
MYPRHDDVSLFQRFVNDHKLEEKGLPLYQLAQLEGTDQVMLGVDGTKIIDMITQAVREREKMAIYTYTTPYTVYEKINEFRTMFQSIKNCTPVFVFNGIQYSPDSAEEFGREKNVVPSEVAALTGTDSSRLSNTTNVRFAEIHKKTANRFVVEEDVEGQIIRIFRSEFKNTIRAPYLAWAQLSSFRHCNHRHISEVYGCLELLAFPGIDRVVTNINPTRGTFDVVYKARVLEAARLSEEDLSSLILVESRSRVMRTVTLKFSSLEDMIKKVVRYKGSTIGASFAQQLHEEAIRASEANRMRASNQRGAAFRNLSAFASPVLTLTPPHCLPLHFLYGIPGFPHADAESFVGLPLPPVLYYIMSAGLLSPSLFAAVSQETVVDDWPLVDSIKYRDVAETVLPLRVQTIYQLAWTMSRGLGSISWFRRYNVLPARVSKLHVPPAIQLDGWALHSVTVPRGLHLVDVMEFAHLACSVDQVIYNTMEETYAAILLQSLDLLGYLTHETQDLHEEGQSSEPSTFGRALQLCSVPTLSEYTVLLIELARTNAISTEPFRITTEEVSPRDTPRDIVFASRVLSIIPLNVSGPWTAPIDAELAAFSMLSRMISRSIRQLLEAITTLMFSKGRTHVPLHRIGEIQRLLPFSTPVEFGCGVLVEYMLMKDKCTLKDLEEAFPECTYLRHDLATLFYFWDLAVQVLQRIETKENFCVDQHCLSSANERMKRAQKNLNILTGVRETYY
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MADVVAARQQLLEVNKATVMYSDWELAYDLQLEEAMAASAMDVPPVKSQIREGKRPVEESFVQETLPKNSLDKTTLDVRDRFSALGFQSAELQILEEILGDQKKAAKEAQDLIQEFRMRSHDRQFAKSVDEMPDTEWEEEGDIYEEPFHGLDDDYWDENQVCKLYTGRAREEPGHVAMAWSLRDAEGHVLVESGKYLGMGTAAYVAEYTALIEGLSYAVAAGVKNIQARTFSHPVFNQVSGLWKARAPKHIKLLEEVFEHTKQLKVFNIRLTSRRTVENLAHDAIRKHVTQGPKDIKRLKPSSSGFVTTPEETDMIDCPVCLENVREADTFVVQECLHRFCVSCLTQHVQIRVKSNQVPVKCPQDCSRLVDVEQCRNFLPPDLVELYTKSLIEASIPESERVYCPFTNCSALMSKGDLNPSSRPSSSRPSSSRQPKSFAIGQVECMECHRLFCVECQVPWHADMSCEDYNNLPPDGRAAEDIKLYKLASNKNWQRCTKCRRMIELDQGCYHMTCRCGHEFCYKCGAPWVDKHATCKCKLWDEEHIVGDPFSSDSEIDANSESDVDSVFDDDGLFPRRRPFNPLAVSELLYKTKLCRYWMSGNCRLGQHCKFAHGEHELRYL
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MFLHQLDLTTALRPSLLPEETLLFVQDAVGLYEGKFKIPQYQHGQAYLTSHRVCYVDHAEPRKNSVAIFLKDVEKTEFYAGFLKSSAKITLLPQTLEAAHTRSVSPNRCREPDRGDSAPTQQPCTSTTAKRYLDFKSGGALPLPSANGMVSCPRCTLENHPSLSTCEICGAPLTTAVDRRLDLARDVSRPESPGPSLAATAQSAVPECIKVSFRQGGEKIFHERLKNALVQRKWLLHSAPPIPKPRPASGAFEDNYSIKSDQSSAEPERPRVVGIAGLERRGLEQRQNNEAMIGSAFEDLEALMTSAKEIIALAEQFASQANIGSNGNSEASVLASQSASALGLVTTKDMLGTGSGSESLEGGIMTLVDLWAVFNRARGGVELVSPSDFEKAARMWDTLKLPVRLRQFKSGLLVVQGRDRTDEKTIASLLAWLHGLHDEPPSADVTWDWQMYGRGVTAQETAERFGWSVGVATEELEMAEEAGALCREQGLDGFRFWENWLVKLSVTSVDA
The following text describes a protein:
Function:
Catalytic component of the DSC E3 ubiquitin ligase complexes that tag proteins present in Golgi, endosome and vacuole membranes and function in protein homeostasis under non-stress conditions and support a role in protein quality control. Mediates ubiquitination of vacuolar proteins such as CPS1, PPN1, PEP12 and other proteins containing exposed hydrophilic residues within their transmembrane domains, leading to their sorting into internal vesicles in late endosomes. Targets also the unpalmitoylated endosomal SNARE TLG1 to the MVB pathway.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MEIDGNTLVFIIVILFLFFSSPGGDGVSSQYEFNQLQRLKQQFRTEHNTFVNMTYTDSFRNITGLKLSYQDMLNNPLQNATYPLPGKDYDRWFPNQNYMVLPNDVIEAINTEVWNTSNDDASNLFPPNITSTLLGKIDLVSNNKYEKIRMPVPRFYEPATDFSEDIPPEGETYWSEWPSYGELHNVSFQHGEIAIQISHMSNLQDNNNYLRRNFINKKNDRWKLLNLQIDFSDKAEKEKHSIYSKAVYDIQRGRILSISQSSKFHSLFALPHYMSFQNDYNEKIFNDVKELVDEFWNFTDYTDVMTMKDVQDAYNNANFKCEYLIFLQLEPWNQYTRDQIKLIDDELNWPLGRPANLSSLPPINVVSGLLYSPDCGVRLGLHNVKGTRYELKIMSIRKHLLFGIALFAAQIYLLLTQMHHTNTPSMVNKISFYCFSMINLVDGSLATLYFVAASVVPELYLPLVISAFSCFILASIFEIRYLISIYASQVNEQNVGIINLLRGNTGTYDENRPRPAFIPDEGSIGGSLYGRFFFMLIIFTFLILSSTSWPRQLRMVFEYILIFILNSYWIPQIFRNAVKGIPSRRERARSSIGGNRSQNKMPLLWSFVIGTTIIRSLPVVYVFTYSSNVFRHHKDVHFVVFLSLWLLFQISILYSQDVLGSRWFLPKHTIPDGYSYFKPLSNEYISEHGGGTAEHTVDCAICMSDVPIYIEEIPETHKVDQHSYMVTPCNHVFHTSCLENWMNYKLQCPVCRSPLPPL
The following text describes a protein:
Function:
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDGLVVSGTTGESPTTTDGEKIELLRAVLEAVGDRARVIAGAGTYDTAHSIRLAKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPGRSAVPIEPDTIRALASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKINIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGRRNKTQENLTLLQLQNYIKRDPGSYRDEFTQQYRYYQSNLKIFQLQPSQPSKTMIELIMFISQVAHCYPEDLDTFPQELIDLIRQYQDVLDTDLRLAICRALILIRNKNLLSPTSLLELFFELFRCKDKLLRKTLYNHIVADISNINLKHKNNKVNKALQGFMYKVLCDGDALATRYSVEVMIELYKKSIWNDSKTVNAIVLACFSNVAKARVIAVKFFLGTDDIEDGSDSDDSDDAVSICNLYLRISYDHYLGERQNSLRYYPTKMKGLLVSHNVSKKTKKKKKTLEKALAALKKHKKKRSAKSSSFSALYLINDPQAFAEKLYKELEKAGDKFEIRIMIADLISRLVGLHQLFLFNFYPYLQRYLQPHQQEVTKFLTFVARSSHDLIPPETLEPVLRTIVNNFVTERNSSEVMAVGLNAVREMCAKCPNVMTEELLQDLTQYKSSKNKSVLMAARSLIQLYRYINPSLLRKKDRGKPMELSKEVGPLAFSEVKAAGHVPGTEFLEVSENVDGEEEIDSAIAYVDSDEGTSDDDAISLNSEGEDDDASSSEEIPAERKTDKRAEKARRTMSTDSDQFDKIRTEKVLRELDMRTGGKMKRKHLETMVDNEMEKELSKPIISQDDIEIIHKKARHDRESRLATVKEGREGRGKFTNEKYRMNEFASTSHKEKRKGKSFMMVRQAKGVQRKIKRSFRQKQLALRDSMLKRRKSKR
The following text describes a protein:
Function:
Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
Sequence:
MPIEWVKVHDYTDIIYEHDAAGEGIAKITINRPEKRNAFRPETVNELIDAFSRARDDERIGVILFTGAGDKAFCSGGDQSVRGIGGYVGKDQIPRLNVLDLQRLIRIIPKPVIALVAGYAIGGGHVLHVVCDLTIAADNAIFGQTGPKVGSFDGGYGSNLLARMVGDKKAREIWYLCRQYNAQQALEMGLVNAVVPLERLEDEGVQWAREILEKSPLAIRMLKASINAAADGYAGLQQLAGDATLLYYLTEEAQEGKQAFLEKRKPNFRRFRRYP
The following text describes a protein:
Function:
Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein; Periplasmic side.
Sequence:
MIDFWLAAGLLLLAALAFLLIPLLRGRRAQAEEDRTALNVALYQERIAELAGQQAAGTLTAEQLENGRAEAARELLADTEGSGEERSSRLGRAVPLVAALLVPLVALGLYLHWGASDKVELAREFAQAPHSMEEMTARLERAVQAQPDSAQGWYFLGRTYMTQERGADAARAFERAAELSGRQPEVLGQWAQALYFSGGKKMTAQIKALADEALKGDPAEVTTLGLLGIAAFEEQRYADAIGFWERLVSVLPNEDPARSAIQGGIQRARERMTEAGQTPPAPAAPAAAGVTLTVKVDISDAVKGQVKADDSVFVFARAVGGPPMPLAVKRLTVADLPAEVSLSDADAMMPQLKLSGFPQVELVARVSRAGNAISGEWIGRGKPLSTAQSSAQALTIDGPDQPQAARP
The following text describes a protein:
Function:
Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MKIKRFFAKDMRAALAQVKDTLGSDAVIMSNKKVNGGIEIVAAVDYDEPKAKASAAAPTFMDVSDDLVSLGGKAPIRAETKLKPSAPADSLQALLEKQQNRLNQQLTHQQQDAELPAWAKGLQAPAAAKAERRDIANSFDKKPQTSQKQNADLEAMRDELASLRNLLTHQVSALMTEHKKRIDPVGAMLESKLLEAEFSPAVASKLAALSQHYTPAELVRALPQSLANMLDNQGDDIVKQGGVVALVGPTGVGKTTSLAKLAARFAAHHGADQVALITTDHYRIGAYEQLATYGKIMGCPVKQAHDLAELEQILYQFRNRKLVLIDTAGMGQRDMRLYQQLDNLTANSRIPIRSYLVLSATGQRRVLQDAVNHFKRIPLSGVVLTKLDESVSLAGALSVLIQSGLPLSYVTDGQRVPEDMKVADTLMLAEQALAALENTEQQSLPDTAWSDNMTCAFE
The following text describes a protein:
Function:
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MYLRCTMELNNILFVMTLLLYGAASMKSQAYFNKTGELPCHFTNSQNISLDELVVFWQDQDKLVLYELYRGKENPQNVHRKYKGRTSFDKDNWTLRLHNIQIKDKGLYQCFVHHKGPKGLVPMHQMNSDLSVLANFSQPEIMVTSNRTENSGIINLTCSSIQGYPEPKEMYFLVKTENSSTKYDTVMKKSQNNVTELYNVSISLSFSVPEASNVSIFCVLQLESMKLPSLPYNIDAHTKPTPDGDHILWIAALLVMLVILCGMVFFLTLRKRKKKQPGPSHECETNKVERKESEQTKESFSVFAPAMPPSWNLLLPLFCLILQILVQAELLKKENKNQKTTFLKLHYVSLLSCHLDPYAFSS
The following text describes a protein:
Function:
Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function. May sensitize cells to DNA damage-induced apoptosis. In skeletal muscle, mediates TNF-stimulated oxidant production.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Nucleus envelope. Cell membrane, sarcolemma.
Sequence:
MAFPHLQQPSFLLASLKADSINKPFAQRCQDLVKVIEDFPAKELHAVFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVEYSTAMEFLDPSGPMMKLVYKLQAEDYNFDFPVSCLPGPVKASIQENVLPDSPLYHNKVQFPPTGGLGLNLALNPFEYYMFYFALSLISQKPMSMTLHVRTSDCAYFTLVDRYLSWFLPTEGSVPPPLCSSPGGSSPSPAPRTPAMPFASYGLHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKLEVLHYRLTVSSALHSPAQPSLQALHAYQESFTPTEEHVLVVRLLLKHLHAFANSLKPDQASPSAHSHATSPLEEFKRAAVPRFVQQKLYVFLQHCFGHWPLDATFRAVLEMWLSYLQPWRYAPEKQAQGSDPQPRCVSEKWAPFIQENLLMYTKLFVSFLNRALRTDLVSPKNALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELIIPHRQHRLFTVTTSFLSPWPPVVTDASFKVKSHVYSLEGQDCKYTPMFGPEIRTLVLRLAQLITQAKQTAKSISDQYVESPTGRSFLSWLTFGLTDTNSCYPANDLDEIGQDSIRKTDEYLEKALEYLRQIFRLSEAQLAQLTLALGSARDENGKQQLPDCIVGEEGLILTPLGRYQIINGLRRFEIEYQGDLELQPIRSYEITSLVRALFRLSSAINRRFAGQMAALCSRNDFLGSFCRYHLTEPALSNRHLLSPVGRRQVTNPARGPRLSLRFLGSYRTLLLLLMAFFVASLFCIGPLSCSLLLVLGYVLYAIAMTLLTERGKLHQL
The following text describes a protein:
Function:
Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to centrioles in proliferative cells and basal bodies in ciliated cells. Disappears during ciliogenesis but reappears, albeit at a lower levels once ciliogenesis has completed.
Sequence:
MKTPTSTIQTNAATATHGNLVSTSNANFSEHMDERSSVLTQDTQEFLTDLLNRQKTRLNELSSHLSSMAHSETFLSSLKSSMHWPVEELTCDKVVTLLTKLKDTDVAANSVETLIEKLKDSSRGILRADNVSSLDAIDISKQNDLLWKELETFRHIRGILESFLQTHYSKSSRLINQESVEVLMGQLLEHEKDNLRLREQVVEKETKVEDLLHLIQQEKDTAVKSNQVSRSTEATHIRLQNLVKRKETENQQIVTQIQSLAAVISGRKLEIEDLRREITHLKEKQTFEKEGLKKAFRVQKQKVDNFQDVMENLNTQIKKKETELSEVHSSCSIWKDHHDSAVETKTRLEVQHESLTKQISDHLKLIKTMDEEREQSKEENAEKISAIILENAHFSEENVKLKASIAALESETVLVNSELLEVREKASQQKHFAEQYENQVQKLQEELNKLKEKFKDVLTKKKEILENKASENKKVDTNDYFLGNESFKLENNRIERKCEEIRIKLEKMIMHNEQLESKLKGQERDLQRSEVELEGKAKECSTLMRLLENAVEAGNKQISEENNKVLSKELALQRKLQSLESELKRKRAEHKQLGCTLNAFEKTHNLRLEEIRHSLEMTESRNKSIQSYVQFLKTSYAAMFE
The following text describes a protein:
Function:
Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
Subcellular Localization:
Cytoplasm.
Sequence:
MDKKPLDTLISATGLWMSRTGMIHKIKHHEVSRSKIYIEMACGERLVVNNSRSSRTARALRHHKYRKTCRHCRVSDEDINNFLTKTSEEKTTVKVKVVSAPRVRKAMPKSVARAPKPLEATAQVPLSGSKPAPATPVSAPAQAPAPSTGSASATSASAQRMANSAAAPAAPVPTSAPALTKGQLDRLEGLLSPKDEISLDSEKPFRELESELLSRRKKDLKRIYAEERENYLGKLEREITKFFVDRGFLEIKSPILIPAEYVERMGINSDTELSKQVFRIDKNFCLRPMLAPNLYNYLRKLDRALPDPIKIFEIGPCYRKESDGKEHLEEFTMLNFCQMGSGCTRENLEAIITEFLNHLGIDFEIIGDSCMVYGNTLDVMHDDLELSSAVVGPVPLDREWGIDKPWIGAGFGLERLLKVMHGFKNIKRAARSESYYNGISTNL