lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Has antibacterial activity.
Subcellular Localization:
Secreted.
Sequence:
MRIAVLLFAIFFFMSQVLPARGKFKGICERPNGSCQDFCLETEIHVGRCLNSRPCCLPLEHQLRIESTTPKKD
The following text describes a protein:
Function:
Transcription factor (By similarity). Plays a role in embryogenesis and later development, perhaps acting redundantly with forkhead protein pes-1.
Subcellular Localization:
Nucleus.
Sequence:
MARFSILDLCPDLVEEAVKIEQLHISTQPCIKQESTDISDPSTSIDTTDTMSTDYLHDESIDDERSESTLSKDSKSPSSSNSEEKTPSSPNDKPPFSYNALIMMAIKDSPEKRLTLAGIYEYIVTNYPFYRDNKQGWQNSIRHNLSLNKCFVKVPRNFDDPGKGNYWMLDATAEDEVFIGGATGKLRRRPSSLSRARMDAYKQYGAAAANLFPYFSPGMPALPRHPYLTAPNGFLPRQMMPIPAMPQVFAQPELLQLYINQQQSLFTKLQ
The following text describes a protein:
Function:
Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins.
Sequence:
MTPSLKISQKVVNKLSNFSQEILGKLYGIVTKNTFIVLGLQTELENGSGNALINSLPAEIYLCGVFQSGSETFNEQSIKSSLAEVYVTDNPVFVHYNSSTNKITAHFYINGQLETTKFAPISEQEILSQFLYLRLKANVPLTCELATNSLKDSFTNLRKNVASGVMSFGLGKNIYLVGSDSEGIVGVTGNPSIGELFETSEPSEGGARKKKVQNYEIDVMGVDMLKMMTKELGVAEREHAPLCVLDKKQCKTMTIMVSIDSLSMVNRQTKIANLYEILVESAVRNLRLLESSILEKLQNEDDTIAQPEVFHFYPDDCGHFVTKIYLKGETEDALLPVRETLHNELLLSGCRPMFRRANSFAFKTKNPGNEPLINPHLGLKPTDNGGKVALVKGKYAYYHYCQNKMDDNGWGCAYRSLQTLASWFKLQGFTDKEVPTFKDIQKCLVDLGDKPSSFIGSKQWIGSTEVNYVLNTLLGVTCKILYVSSGEEMGSKGPELLSHFENHGSPVMIGGGVLAHTILGVDYNSQSGNLRFLILDPHYTGGEDLHTIQNKGWCGWKSVDFWDKTAYYNMCLPQVPKGI
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MAQQASSSFIGLDTVDDLYFSIVFDQETDPVFVSDDKYAEALQFQETLMASAITSHQNHSSSFSSSPPPFFPCVASSSKTVDDELLFNETLMKSLVISQNASSSTSPPLLCVASSSEVVDVAAVVKTEQAKVFTQETDEPSSITVCEICAETKTTDEMFRNLRCYHSFCSECVVKQVATKIQDNITNVSCPGLNCKGVLELESCRSLLPKELIDRWNDALCEAFFLAVPKFYCPFKDCSAMMLDENEDGQDIRESECHVTWHPRVGCEEFQTMNVDERGREDLLVRELANKKKWKRCPRCRFYVEKNDGCLHISRAGANLSFAMRVVQDGHLLMVVVKEIR
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MNRPCNSMEPRVMDDDMLKLAVGDQGPQEEAGQLAKQEGILFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLVYLDYRRIDDHTKKLAEAKHQYSIDELKHRENLMQAQLEDEQARREELEKHKTAFVEHLNGSFLFDSMYAEDSEGNKLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKTELDTFSECVHEAIQENQEQGKRKIAKFEEKHLSSLSAIREESELRNIEKMILECSADISELFDALMTLEMQLVEQLEETINMFERNIVDMVGLFIENVQSLMAQCRDLENHHHEKLLEISISTLEKIVEGDLGEDLPNDLRALFVDKDTIVNAVGASHDIHLLKIDNREDELVTRINSWCTRLIDKIHKDEIMRNRKRVKEINQYIDHMQSELDNLECGDILD
The following text describes a protein:
Function:
Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSDYTNVSWDNVTYYGGNGVALDELELKVSWHNRPASSWSVRRIGALQHKIEQYTFKIYHVNRYGKHSLSQVIPTHVLIQFANEAFGYNGWSSAVEEVLITDVKQRERVRDGAAIELYTVTAEARVKLTLQDGTNTEATGLSKITLPSKGDAYGKAKKEASADALKRCLLSFEGIVIEHEQKVASNYYTDGEFGSRKAGDKRDR
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSTINVEHTYPAVSSLIADLKSRKVQGPFAVAVETALVMRQVISQTRWSTVDQLIDTVRAVGSTLVKAQPTEFSCGNIIRRILRLIREEYQELLKTADENEKLIVSSSNSSSPSQKRDIPSNEKLVQSHEPVSVQMYSSMLNLLGRPTLESPTHSKTVGDSRVTGGMDMRAVIISGIQDVIDELDKINTDIEVQSMDHLHSNEIILTQGCSKTVEAFLRFAAKKRKFSVIVAEGFPNNQKGSHAMAKRLAQAGIDTTVISDATIFAIMSRVNKVILGTHAILGNGGLVTYSGAQLVAQAARHHATPVVVCSGIYKLSPVYPYDLESIIQLSSPDKIMSFNEGDLISRAEILNPYYDYIPPDLVDLFITNLGGYPPSYLYRIMNDTYDASDTIL
The following text describes a protein:
Function:
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.
Sequence:
MYDNVIHTDGFVSAIEFCPYESATKLLAYSSAEYLHICSVTFQHEEQSSQQEKQPVRSVVTHHEHLKKYSQDGITSISWSPSSSMKYLPRCGKLALGLLNSKVIILTTDFKEETTHTTLEGHKSGVNSVAFEPLEGNKLASVSDDNTCRIWDSVNESILHVLCLQHAGINVCWNRLEPDVLMVAELSGSIRFYSLDEENEAPLPLKWLHCGRGNLTAADWCPINPMKVGAAVGTEWVLWDSTKSSLSEDTRQCHVGGSIMFRWSRQNEDVFLTQGRPKHSLKIHHLGHRELLRHETLQVGSGATWHAIHPICAVAGSQHIQFYDVSSDL
The following text describes a protein:
Function:
May influence gene expression by regulating the function of the PRC2 complex and modulating H3K27me3 level.
Subcellular Localization:
Nucleus.
Sequence:
MGNILPTGSRVSENEGSDDNKLKEHDVKMENVKEDSEQIGDNVRSGVSSLRDNFEELENGFHVGDFVWGEEANSQQWWPGQIYDSLDASDLALKTMQKGKLLVAYFGDGSFFGWCNPLELKPFLENFKEFSKMSDSRRFLLAVEDAVREIGEHVEKFLVCDDAALVSSVALNLGIKDGVVVPDVRRKIISSLVLENPGVVLEDVKRLAMTVRFDDLLEIEVLRRKISAFYRCKGRFDLAKFDEHRYIIGLEDKEHESCQRLLRKCSGFASKKRKCGDVATTGSTTLRKKRLSEVSKIETAEKEISNGKSLSSRKRKSKRGLDENDDDGIEKREESNDSNHLEESEKKDDLATPLASICKRLNVDVSSCVKRCNGNGEAILQTGKRERKKSKYLSPEYMTDFSCRARKIKIESAESSQIQVAVRMTTPNTAIDVVKLGATPEEMLALIRAAALNAQYPKDYNSTSCDMVREFVSNYRSFNNKRNLSDVEKQPEVKQEIVDEKEKTRNEPGVELYIKTGFGSTLPSKDDLIKTYEKFGALDKERSYMFNNNSCSCVAFVNASDGEEAFNRSLEKCPFATTSTVTFKLEYPSSASSEKKEAETRKGVTEIECLKEKLEGIRALLDQSEGKITEELKMKLEDESRNLLDKVRKMII
The following text describes a protein:
Function:
Involved in the lipid remodeling steps of GPI-anchor maturation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNYLLRCTFTIGLLAYTALASPGDDLYAFQDCLYQCEQITCNNNPYHIIQQEFYTELSNNPDYEFRYYNPHWQFDPMPLPLHLRLLGWNCESNCDYQCQRIITGERIKNHEEIYQFHGKWPFLRVLGIQELTSVVMSLGNLYVNYQSFKKIWSSVITNDSVPSNLKYQFTNIFVVQIVTMCAWLFSTIFHVRDYILTERLDYYFAGLTVLTQFHALGARYFNLYKHSRVVYRWLFSLACILAYVYHVHRLYTDWSYTYNMQANICVGLSQNVFYCLVCFGLYVKYYNLEQTENKVILNHLNYVDSQRIILSSFFTRSSKLFSLYPLLLCFIVVCGMALEVFDFPPVFFDLVDAHSLWHLVTIVPVYMGWYDWLVWDVYENVWSNIQEEDKKKKE
The following text describes a protein:
Function:
Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.
Sequence:
MSFFERLKTEASVEWRAYTEHPFTNGLADGSLPEAAFRHYLVQDYLFLIEFARAYALAVYKSPRLADMREAAAGLSAILDVEMNLHVKLCADWGLSPTDLEQTPPAAEMLAYTRYVLDAGMRGDLLALKVALAPCVIGYAEIATRLAARPDADAATNAYRVWIAEYAGAPYQEVAAKARAHMEHLADLYATPAREAELIAIFKEATRLEADFWEMAWRAGQLVQ
The following text describes a protein:
Function:
Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
Subcellular Localization:
Mitochondrion.
Sequence:
MASRSFIRRSARIAAAISSNRSVVCSASMSVVGRQCFQATPATAQIRFQSTQAAASSEEKAQPEAAVDPEQRILAKAISHVVVHGWTIEALAAGATDLGYPSVAHGMFPRGAVELVEYFMDSCHDKLRETLIVNTEKLQAMTVAERLKFGVRMRLEMLEPVLATWPQGMAAGALPQNAPSTAKRLAKISDEIWYFAGDKSTDLSWYTKRAILTGIYASTELFMLSDKSPNFQDTWAFLDRRVDETIQLGELPQNLNDVAGMASIGLQSVFSAVTSLAGPLAGQIISNSPLSQVPNPISAVGSVIPPSIVSAVASGLPFSGPASVSSSAGDDAMAFKSKDLKEINEELEKLGGIDTSERRS
The following text describes a protein:
Function:
Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.
Subcellular Localization:
Cytoplasmic vesicle. Golgi apparatus.
Sequence:
MRKDIETLVAQERAEILAKYEKGRQEGAQIDPWEDADFTLYKVTDRFGFLHEQELPEHSALEEKQKLQEIERVSKWLKMLKKWEKYQHSDKMSRRVYKGIPLQVRGQVWSLLLDIHKIKSENDGKYEKMKEQARSFSSEIKQIDLDVNRTFRNHIMFRDRFGVKQQALFHVLSAYSVYNTEVSYCQGMSQIAAILLMYLNEEDAFWALAQLLTNEKHAMHGFFIPGFPKLQRFQAHHEQILSKLFPKLKKHMDKEQMSTGIYTTKWFLQCFIDRTPFTLTLRLWDIYILEGERVLTAMAYTILKLHKKRLLKMSLEDLREFLQEQISGSLHFEDDLVIDTLQASMAELRKMKFDLPPPAKADEFPKKPLGLELSLSPVPAKPAANGRSKPPGSPETPTDPLPQGPPPPRRSPAATGPGLGPTTGPTGPVPPAALPGPRAGPGLDAHAEERRLRGGDRGPPPLAPSCCPDGEAEALCPSAPEDPVVPPRPEDGAPPDSREPEAGPLDGWTGEEEEEEEEEEEAQFPAAPQAPEWEAPAQPYPFPPPPLPEELLPLGTLPEDSWYPPLPPPGAPDEPLHLPPPPPSAAADGEPGRDQEALPAPPAPDTEETLPLTLGAAGRPPSRSADLPPWEAPGPGLAPAWRGPLPKASSVGEMGDLVEREDGGAGAAVLRPRPSGSLPGLCDPRPVPEGPPGRPTPDPPAGARPGHFCLIRTGPPLHVAHATDRNLATGKQVALPLTPTRRAAAHGDPGSRPPDENQTEPPAEAGDGPRPPPPHGPKPVPF
The following text describes a protein:
Function:
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFVLSRMAACGGSCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVLQLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPELHRPGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREDAEEQETTCPICLGEIQNAKTLEKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD
The following text describes a protein:
Function:
Minus end-directed microtubule (MT) motor that is involved in spindle microtubule shortening, kinetochore capture, and polarization of cytoplasmic microtubules. During mitosis, promotes spindle microtubule shortening by depolymerization. During metaphase, involved in the recapture of kinetochores displaced from the spindle and their transport towards the spindle pole body; promotes transport both by microtubule end-on pulling and by lateral sliding along the side of the microtubule. During interphase, required for the polarization of cytoplasmic microtubules where it orients the microtubule plus ends toward the cell ends and the minus ends toward the cell center. Required for karyogamy.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Nucleus. Note=When in the nucleus, it associates with chromatin. Localizes to nuclear microtubules.
Sequence:
MEEEGHKSLTSHLPQSSSSLSQSREIAKEFTSNIPPPTIKTNSSSSNILKPRLSLQNEVNQLKPAKFPSKMLPPGSLASVKSSSLAKKARPFTASSNPRMPKSAHPISSRSVSASSHFGRPASAVSSSLNSSDDVRSMSDESMESYNDEKSVNASALRTTEDRLRSMEMAYAQLSAKVIPSPSKRPANYKFYEQRIAMLEESLEVERSRTSELQEQFSVALREKAEAEANKIVSQKGMESLEIMLNSMKSENHQRMAMLEENHARVMETAELQHQAELQDFASNIEQKANSLIMEYKNELQSAEEHFSHKIKELTSENELKISRLQEEKDSLLKKVQEGASLAMQRVQNKHDLEKKRLQSAIQPLQEENNSLKQQIEQLQRELASETVVKENLKSSLDQQSANVQKLESTNRALESTIKTLEEDVYTMKNKIIELEGILKSANVERDGLVEKLIAEETLRRKLHNTIQELKGNIRVFCRVRPPLGDGESAQIAFPDQNSEASTIEIVAQAPGSSLTGNGIKQYAFNFDRVFSPETTNEDVFNELSQLIQSAMDGYNVCIFAYGQTGSGKTHTMSSNTGMIPSSVRMIYNRSTSLKERGWEYRMEGQFLEIYNETIIDLLASGNEEEKGKKKLEIYHDTKAGRTTITNITSEPLDTPEQVTWLLDQASKNRSVAATNANEHSSRSHSVFMLHLNGSNSTTGETCRSTLNLIDLAGSERLSSSQSVGERLKETQAINKSLSCLGDVIHALGSGKEGTYIPYRNSKLTNLLQYSLGGNSKTLMFVNISPLKQHVPETLCSLRFATKVNNTQIGTARKVTK
The following text describes a protein:
Function:
Inhibits fructosidases from vacuoles (vacuolar invertase VI).
Subcellular Localization:
Vacuole.
Sequence:
MKMMKVMMLIVMMMMVMVMVSEGSIIEPTCKETPDFNLCVSLLNSDPRGSSADTSGLALILIDKIKGLATKTLNEINGLYKKRPELKRALDECSRRYKTILNADVPEAIEAISKGVPKFGEDGVIDAGVEASVCQGGFNGSSPLTSLTKSMQKISNVTRAIFYSNSIVKEEACGSSWPSLALNIDSKACVVSLQNIQFNRGRTCW
The following text describes a protein:
Function:
Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.
Sequence:
MDQQFIKGIPFSTLEYAKAISLLKGWLYEQQEKPRFVVTANPEIVMSAKENTEKSKEFKKMLLSADLITADGIGVIIGSKILKGTLKERVTGADLTHDLIKYCNDNEYRVFLFGAAPESNKKALEKLNEQFPGAQFKGQHGFVNGEEIEEIKMKIKQFKPHLLLVGLGSPKQEEFIYENIQTLNVPLSIGIGGMIDIISGTVKRAPKIMRDTGTEWLYRLLSQPKRLKRQLVLPKFLLSVMSERIKGIN
The following text describes a protein:
Function:
Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins.
Sequence:
QTIHWIHDVIPNQLVLQKFERSKTWSYLTSVHFSKDVVLKAYKLGKALQRKNNDELRKIHEEKWLKLWKKGRIEMKGVSDNATRLTKAITSSLYNLLSSLPDFSNENNLFESQWKQKDLMESYLFTGLSPSGLSWGDRKDHKNMQAYRGHLFWDQETWMYPPLLMLHQSSAQLMLQARLRTMYTAGENAKIEGFVGMKYPWESALTGIEVSPDRECGIREIHINGDISLAVLQYLRVTDHNLTCQGNVPKLIIGIADYWLSRSVWNNSCLRFEISCVMPPDEYSRCVNNSAYTNVVARISLKLAFEVAECLKLPNSTVYENTFKRMYVPFDGELNYHPEYDGYVLGKIVKQADVVLLGFPLMYNMLPDVRRRDLEIYENVTSVKGPAMSDAMFTVGWLEVHEPDRARRSFEKMFDHVTGDFQVWTEVKGGHGAPNFITGMGGYLQSIIFGYFGIRIYRDKLLINPELPTDISSMALYGLDYKNCSLDIFVGDRNEMVIKWSGDVGCSRLLIVSPTERLRLSGSRKMTISKSSLYIRVIHERGTNDACFP
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MFSVNRFDPNQHQQQPSQEDNDKQTFNPLSRLNQRLQAKNLSVSTVEASTEIEASTEKPVEPKTTQTTTINNIHVDRLYNDEKYEPSLDLTQPLTKKQKARLQLGFTGANTIPLPSSEPPKPKSSAKLKYLKRKKDRKKSRKRTSTTSAETKKTIKQEPSQSTPADHQTPQPENHPSSSSNPPPVTTTDHDPSTTSLQEPSSEKPKRAKRPKNLDVALEKISKKKKRNREITSVEQEEGNASEAATAEDPEVQQTALVEEISQPGALPRFPAPTNPSLPDPQLLARLAMGLGDPDPSEIAESEHDNSMIQFDSASTLPLSQLESRASSPGQFIQSLSLSSQSISRLKQLEFENLLAVQIAVFSLLMPPLSAYSNTPASSLYPTRRPPRDLCVSAPTGSGKTLSYIVPIVETLSSRVVCRLRALIVLPTRDLVLQVKNTFDCFSKGTGLKAAIITGQHSFTKEQAQLGCSRDGLEGSVDVLIATPGRLVDHLNHTSGFSLQHLCFLVLDEADQLLNKSQAWLHQVLSTSAASEVPKPMEHTEPIKSSFNHPKSLLGFRSSEPFEPSHLLDGPLSTVEMHNQDHGLTENLPIETYNPCRLRPFRILLFSATLRRDPVKLAHLGLRHPVFVKISSSSTTLVVDGDLDQTRRESGTIDFVDQLNGYCLPKTLKQYLIVTRTDLKPLVFFKLLQSQRIEKALCFCKSIDGARRLTGLCRLMAEQFQALKSPNSDDPESNPKQKDQDQKDQKDDVDLVKLCKVECFSSDLSPVERKKLLNKFQSGEINMLICSDIIARGIDITGVQNVINYDSPIDIKKYVHRVGRTARANEHGRAFSLVESQEAKFVKAFLKTGFGSLAPEQQLARIRIDWLDLQALLPSYNIALKKLGDLFGRSIDL
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSHPTARGAGEKAPLVRGNFSETHGDPYVEELGPGALVYTASLIRDDRTSRTSGTISTVDCDPTDDDADWDVEKAKLRNCRNAKQQQTQHTFHTTGGKPSSNELWRFRTRGCQDCWAALFFAALIVVVLLWGMEQVWQLQLTERDLAVIAGVAEGKGYADTHTVAAVAGGSVHGKVLHGVAALRAGVAALWAGVEGLEPPADAHNSDASSPSSYAGMIGAVVQALIWCATAATTTILVAYGGLLLIAVYPRQLIFIQSAVASMFSAASAGVALAQGAGLMAMVFAFLAFTPLLWIYLIHDRIPFTTTMLCATVSVLQRHRSLFVISLGSAIASWCFVLAAVVCVLPSVLRFLAGTASSADIAYPVILVFGIFWVQEVLTALVHVTVCGVVATWYFAGEGNMPSFPVQASFQRATTTSFGSVCLGSLINAIASFVRFLIDTVRTSSDGDNFWMCIMSCLVGCIEDLVRYFNQYAFVHVAVYGCGYVDAAKETWALVKQCAFSAIFNDLLTGQVIGILTFMSAVLVALLTALVTWNAAAVALMFFMSLIVSSIFYNPVSSCVTTIYVCFAEVPVGLQLSFPELYAALVDADAGYTQRREEASVYGTALV
The following text describes a protein:
Function:
Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Also binds to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway LRP8 and VLDLR form homo or heterooligomers (By similarity). Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 on its cytoplasmic tail (By similarity). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone.
Miscellaneous:
MISCELLANEOUS: LRP8 and VLVLR together are required for correct embryonic development in the brain. Targeted disruption of both genes results in a phenotype virtually indistinguishable from that seen in 'reeler' and 'scrambler' mice. Subtle effects of VLDLR deletion are found mainly in the cerebellum, whereas lack of LRP8 predominantly affects the positioning of the neurons in the neocortex.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.
Sequence:
MGTSARWALWLLLALCWAPRDSGATASGKKAKCDSSQFQCTNGRCITLLWKCDGDEDCADGSDEKNCVKKTCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDESPEQCHMRTCRINEISCGARSTQCIPVSWRCDGENDCDNGEDEENCGNITCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDCAPPTCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDESLEQCGRQPVIHTKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDMSKVCDQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHFKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGAKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEDDMENGGCEYLCLPAPQINDHSPKYTCSCPNGYNLEENGRECQSTSTPVTYSETKDINTTDILRTSGLVPGGINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
The following text describes a protein:
Function:
Cleaves the gamma-glutamyl bond of periplasmic glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases; it may function in amino acid uptake/salvage, or possibly in peptidoglycan linkage. Catalyzes the hydrolysis and transpeptidation of many gamma-glutamyl compounds (including some D-gamma-glutamyl substrates), with a preference for basic and aromatic amino acids as acceptors. The KM values for gamma-glutamyl acceptors are so high that it has been proposed transpeptidation is not the physiological role in E.coli.
Subcellular Localization:
Periplasm.
Sequence:
MIKPTFLRRVAIAALLSGSCFSAAAAPPAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDTLVQANLAKSLEMIAENGPDEFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTGSPGGSRIITTVLQMVVNSIDYGLNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
The following text describes a protein:
Function:
Indole diterpene prenyltransferase; part of the gene cluster that mediates the biosynthesis of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels. PaxG, the geranylgeranyl diphosphate (GGPP) synthase is proposed to catalyze the first step in paxilline biosynthesis. Condensation of indole-3-glycerol phosphate with GGPP by paxC then forms 3-geranylgeranylindole (3-GGI), followed by epoxidation and cyclization of this intermediate (by paxM and paxB) to form paspaline. Paspaline is subsequently converted to 13-desoxypaxilline by paxP, the latter being then converted to paxilline by paxQ. Finally paxilline can be mono- and di-prenylated by paxD.
Sequence:
MQSDELQIPPWESLAEGLGFSNADEEYWWTVFGQPLNKLMDWADYSTSEKYRVLAFIHRYVIPTCGPRPKPNGDQYWDTFMGFDHTPIQVSINFYNSKATVRTGNIPISEASGTTEDPINQKASLDTIASQRHLVPGHNLRLFKHFTDAFFIPNEEANILNAELENRTIAMQAVQCMLSYDFPYRQIQTKVAICPMWKSMQVKRPMGDLMISSIKDLGIDAADYMKSLKVIEDFINSEKAVQSGAYAIFFAFDTMLTDDYQRTRVKIYFATQSTAFNNMVDIFTLGGRLDGPEMQRATKELRKLWMSTMAIPDGLRDDETLPKSPLPCAGVIFNFEIWPGADKPNPKIYLPCAYYGKDDLDIADGMDSFFKDQGWSKSFHSYKDNYIKAFVKDGKVMCRHHDISFSYKGQGAYITAYYKPELSEYADPSVWAPKLFKA
The following text describes a protein:
Function:
Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. The relevance of acetyltransferase function remains unclear (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MELGKSKFSWKDLQYCDKAGTQNSPLRVVAHIDQDAFYAQVESVRLGLDHSVPLAVQQWQGLIAVNYAARAANISRHETVTEAKKKCPELCTAHVKTWKAGESEAKYHENPNPNYYKTCLDPYRHESVKILNIIKKHAPVVKKASIDECFIELTSDVKRIVLEEYPYLKIPSEDSNVALPQAPVLLWPAEFGMVIEEEVVDRTKEDYERDWDDVFLFYAAKIVKEIRDDIYLQLKYTCSAGVSFNPMLSKLVSSRNKPNKQTILTKNAIQDYLVSLKITDIRMLGGKFGEEIINLLGTDSIKDVWNMSMDFLIDKLGQTNGPLVWNLCHGIDNTEITTQVQIKSMLSAKNFSQQKVKSEEDAINWFQVFASDLRSRFLELEGMRRPKTICLTVVSRFLRKSRSSQIPMNVDISTQFIVEATSKLLRQLQQEFDVYPISNLSISFQNIIEVDRNSRGIEGFLKKSNDEIYMSTSVSPSIEGRAKLLNENMRENNSFELSSEKDIKSPKRLKRGKGKGIFDMLQQTAVSKPTENSADETYTCEECEQKITLSERNEHEDYHIALSISRKERYNNLVPPSHDKPKQVKPKTYGRKTGSKHYAPLSDETNNKRAFLDAFLGNGGNLTPNWKKQTPKAISNSSDNMTQLHLDLANSTVTCSECSMEYNSTSEEDILLHSRFHSRVLGGVTVSFQCSPIYRVNYGLSSDCIYSINSESSLIDQRKAEEALSFVNNELSSEPIETIGVDKYTTFLFISDKKCVGLLLAERISSAYIVDELELNNNNSTSSAVYIKNENLRKGFVLGISRIWVSASRRKQGIASLLLDNALKKFIYGYVISPAEVAFSQPSESGKQFIISWHRSRNNGSSKSLRYAVYES
The following text describes a protein:
Function:
Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MPPQSDDKRQAAREVIDILHEISTLLNTNLDRTELSLCVSLIENGVNPDALATVIKDLRTEAGLALRASNESPE