lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAPVPLEGIQTLVANAAAQGGLGGPQEGNRGGMISLAKLIDYIIQRTYHELTVLAELLPRKTDMERKVEIYNFATRTRQLFVRLLALVKWANSASKVEKSARIMGFLDKQSLLFVETADMLSRIARDTLVQARLPNFHIPAAVEVLTTGTYGRLPACIREKIVPPDPITSTEKRNTLLRLNQVIQHRLVTGNLLPQMRNLKIENGRVTFHVQHEFEVSLTVMGDGPNIPWRLLEIDVLVEDKETGDGKALVHSLQIQYIHQLIQTRLVDNPQPLTEVYNCLHFFCQSLQLEVLYSQTLRLMRDRLDDHIHVDEYIPGKCLTVSYWRELTTKGKESANKDLRSELGYRLTIQVDAHDPARPLAVLHVPSLGNKESEIADRAIRSEILSMERLLVHTIYVRTRSRLSDIKLEIQGMVKEVECNLQGSPAILSIAILQPCLRAEQLLITVDTHTGMLQCHVPQYDPPLVPELNNALNGDHSKLPVLISELRFWITQRRCEKTLQHLPATAHERLPLLHHSDHPLTKIGRHRMYIQLHRHPNVVLIVELKEKETSMCEVDCAFHMAVVKPSSIEDNPDDDTIETEIPKVYLKVQTLIEFDTFVATHGPFTSIDSDSDHTELNSLKRKGGVKPEPPTRRSKQPAYFISELAHVVAMCDERLPYVSLANELNKRSIFHQGLQVEANATGLVLKLIQLPPPTTEIGGSPAWHALLKRLLTVSIRVLSKGMMKSWMTEFVFYATPLTSTHPKEQGSRRPVYFQYDMATIDATSRTVDSLLSDWYQIVHLYTIVHDLSEYLKGDKYNLSNMFSIKSYNYSKLVLCYGPEKGAMVSIHWNSGEKAFKLAFGATNNAINAHSLIREQLESHLNEYRNLAQIIQLLHETYEPLISISKLPTLPQLGIQNTRPQVPVQTFTIMAQSCTLIRLAYQGMYCLELRIRGAGLVSLRDGAYSRFDRSNVVDVFSPTQGLKAFLSKYVDETAVFRRRSQSEDDNPPSPVSMETHTSFGSSPATSFNLSSPTSLPANINPSPMPHPSPSGLVANSPLNPQLPSPGGLLSNSSPGPVSTSLPGHSPVSSFMATGHTDGSPFPSSQSMASPAASNWPGSPSMPRPSPARPGQSPGGHPIMHSPQSGDMRTGSHLSRVLPQRSWAGAVPTLLTHEALETLCCPSMHPQGLPGPELAPLERFLGCVYMRRQLQRFIHNENYLTAIPNTELGVIHFKVTEILQCRIGLNPQHLQSLHLKITPLPDHKDVWTSEELQVLEKFFDTRAAAPPYKPTAMFTFCTMLNVPVNVLKDFIQIMKLELMPGLVQQQGMKWSVQWMLRIPPSAMPIVPTGMSGVLVYRAKILFFLQITRIGVQYPPNMEPPSLVLPFIYDVNSNMTQLAEKREAGTVPGMAAASQLLKHFAQFQSNISECSIFPALRELLLNLVLPTEPQQSPAPQIQSPAMQMQQGGQPGYPVSMPMGMMGPQ
The following text describes a protein:
Function:
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLASEKESTLFKDHSQPIRRKGAVPAEVYGFVGSIASIVAYALFILWAYIPEQYLHAAGVTYYPSKYWAIALPAYAIVTVFLAVLVYTALCMMSTKPLDSPYTIKDEYSRSRLPPQNSDDCTEEPIPPVSDMDITEVNMWLYKGQALE
The following text describes a protein:
Function:
Required for the activity of the bacterial periplasmic transport system of putrescine.
Subcellular Localization:
Periplasm.
Sequence:
MKKTLVAAAILSLALTACGGGSDTAAQTPSAKPEAEQSGKLNIYNWSDYVDPETVAAFEKETGIKTRSDYYDSNETLEAKVLTGKSGYDLTAPSIANVGRQIKAGAYQKIDKAQIPHYGNIDKDLLKMMEAVDPGNEYAVPYFWGINTLAINTQQVKKALGTDKLPENEWDLVFKPEYTAKLKSCGISYFDSAIEQIPLALHYLGKDPNSENPEDIKAAVDMMKAVRGDVKRFSSSGYIDDMAAGNLCAAIGYGGDLNIAKTRAEEAANGVEIKVLTPKTGVGVWVDSFMIPRDAQNVANAHRYIDYTLRPEVAAKNGSFVTYAPASRPARELMDEKYTSDASIFPNKELMEKSFIVSPKSAESVKLGVKLWQGLKAGK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MINQTTNLFSQLANQYLKGEIEQDVITDPEIQKIVHGLQKKSETTKSKTLSELKTILPNKSQEFFDQFTPTFVNIYRRYVDNEYERRVLELANQVLSLICEYGKKSLSKKFKQLFPQWFIMINDYNSEISTAAMNAFQVAFPTKEKQVQAIKMCSDQYIIDLKLYLSLSIATIKQESNLEDEKVDHIYERLKVSTINSIKTAIQWNPDNDFIEQIMKLLDFTNKTTIIVELLNTQKTRIVATIIETLHFLLSNEVSAPFVLNKSDPLLKKTVQLFEQKDRLIVSALWKGFVTKLFQRVQQDQILKLQGLENKSLELISKAGFGVGKLLYDQLVVFVSLNPVYSVVDIKKEEVYRQKLASMTKLLNAILSGITHEESRFFSENLINSYFETLYFLICKRMIPPLVQYNQCLGQVKNIIVQSIRSVLQNTLSQQGGQAYNHSPYKQVPASLLQFLNILKVKEEQQEFLNEIIKAITAEFKTLQLDDYSVFVNIIQQLLKVKEESPAYQAVQQYLISVFDEIYNNNDFDKGSQLFEIIPNSKNFKRENFGQKIQEIINNLFSSIEMVSSEEVLKRCAQIKICIYNLQRINQQQLIESILQKIITQEYKQVIPKEEQQSFKLKWICLHNLVDASLDPQFYQKYLTMKDSQLEYNLIEKFVKYQQLQQNETFVTKFLSQSLSITNLSQKIFIPCIIQNANQQILNILISKYTQIGQSVIKTMDKNYLQIFEELSYVMNKLQPQQLIFDVLLQLYLKNQSHKGTFLFKLINKKYQDLFVQFFQTTLPLIRTDTLNQHLHFFQDLFAQLNSQDLLQFLNFNFQSPISWKILSLIEIPQDYFKKMYQNNQLELLAVFLASNYSSIMLYDHKLKRFIQNIVGNQIIPIFLDSYEQQEPKSLDLIKVLFNNTDIVYGVALKNLIKQIIIEERENNYRSKQTDQLAQLIVDQLKIALDGNNVNKLITIRQIINVVDLKQQFQNVLQTYYQSNKISYLDLYTLLLRQQPNLLELEDEAELDKIIKLLFEMNLESNYDKMVAFDFINLICERKTITPFAAYIKQINNLFRQLFQQNVQLKRFYSFSIVSALQFVRKILNFIEAFPIEFIDYLNFELTDSLLQIIQFCENPNPEFMDEQNDTLFIEYAETLLRCIQMEQWQKIDDTIYYQLLQCPFISIQKAAFIALKNIQDHSGLSPVLDGFDMKKEEMRRLRQEDEEDVEDIITFPLDGKILTNLLAWLVVLQNKNCVQFKDKYPTYLSNLLYILQFLNDNGVMARFNYKEIYQQDLNLMVIQDDQSELLKMIVISFYQFIVAQQSYFKQWYNQECNTTQKKQLEDLLQIISKAIYTREIELIELNQEEWRSEGFDIFISKNQQEITATYQKEEQKIEILIQVPVGFPLKPLKVETKKGVKISEDKLKKWSLMIRMILQNENDTILTALKLWKKNIDQQFQDLEECAICYYIIHQNGELPKMACRTCKHKFHSTCIQKWFHSSNKSDCPLCKSQFL
The following text describes a protein:
Function:
Protein kinase that acts as a blue light photoreceptor. Required for non-photochemical quenching (NPQ), a mechanism that converts and dissipates the harmful excess absorbed light energy into heat and protect the photosynthetic apparatus from photo-oxidative damage. Controls the energy-dependent chlorophyll fluorescence quenching (qE) activity of chlorophyll excited states by inducing the expression of the qE effector protein LHCSR3 in high light intensities.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MAGVPAPASQLTKVLAGLRHTFVVADATLPDCPLVYASEGFYAMTGYGPDEVLGHNCRFLQGEGTDPKEVQKIRDAIKKGEACSVRLLNYRKDGTPFWNLLTVTPIKTPDGRVSKFVGVQVDVTSKTEGKALADNSGVPLLVKYDHRLRDNVARTIVDDVTIAVEKAEGVEPGQASAVAAAAPLGAKGPRGTAPKSFPRVALDLATTVERIQQNFCISDPTLPDCPIVFASDAFLELTGYSREEVLGRNCRFLQGAGTDRGTVDQIRAAIKEGSELTVRILNYTKAGKAFWNMFTLAPMRDQDGHARFFVGVQVDVTAQSTSPDKAPVWNKTPEEEVAKAKMGAEAASLISSALQGMAAPTTANPWAAISGVIMRRKPHKADDKAYQALLQLQERDGKMKLMHFRRVKQLGAGDVGLVDLVQLQGSELKFAMKTLDKFEMQERNKVARVLTESAILAAVDHPFLATLYCTIQTDTHLHFVMEYCDGGELYGLLNSQPKKRLKEEHVRFYASEVLTALQYLHLLGYVYRDLKPENILLHHTGHVLLTDFDLSYSKGSTTPRIEKIGGAGAAGGSAPKSPKKSSSKSGGSSSGSALQLENYLLLAEPSARANSFVGTEEYLAPEVINAAGHGPAVDWWSLGILIFELLYGTTPFRGARRDETFENIIKSPLKFPSKPAVSEECRDLIEKLLVKDVGARLGSRTGANEIKSHPWFKGINWALLRHQQPPYVPRRASKAAGGSSTGGAAFDNY
The following text describes a protein:
Function:
Catalyzes the hydrolysis of a non-reducing terminal alpha-L-arabinopyranosidic linkage in ginsenoside Rb2 (alpha-L-arabinopyranosyl-(1->6)-alpha-D-glucopyranosyl) to release alpha-D-glucopyranosyl (Rd). It is not able to hydrolyze alpha-L-arabinofuranosyl-(1->6)-alpha-D-glucopyranosyl (Rc).
Sequence:
MSAATPPFRDPQLPFAKRVDDLMSRLTLDEKTAFLHQFAPAVERLGIAPFRTGQEALHGVAWMGPATVFPQAVGLGATWNEELVRRVGEAVSKEARAMRARDDRVGLNVWSPTVNLLRHPLWGRNEEGYSEDPRLTSAVATAYTRGLRGDHPAYWRTAPVLKHWLAHNNETDRDTSSSSVRPRVLHEYDLRAFRDTVEAGAVAGVMPAYNLVNGRPNHLSPHLGRHLRTWTQEDLLVCSDAGAPSNLVDSEHYFDTHEEATAAALRAGVDSFTDHGTDSSKIVARVRGALEAGLLTEADVDAAVRRQLSVRFRLGEFDPENDPYSGAADTGADFDTPEHRALARDAAEQAVVLLKNDGVLPLAPETRVAVVGLLADECKLDWYSGTLIHRSTPLEGLYERFGADRVSFAEGVDRVRLRTADGRFLHVLPADDASAEAPGTEGALDPALLAGRTDLPPLTTDAVGTELALIDWGEGVLTLRASDGRYLSVAEDGFVRASADQPGGWVVQETFRLEPHDDGHLLRHTGTGRPVQVAADGVKVAAPDAAAGAAAGGAGSADAEVFELVVVERGEDAVTRVAAGADVVVVVAGNDPHINGRETEDRTTLRLPAQQERLLRAARAANPATVLALVSAYPYAVGVETLPAVLWTAHGGQAAGTALARILAGDVSPAGRLPQTWYSDDADLPGLLDYDVIGGRQTYLYFEGTPLFPFGHGLSYASFGYGDLTAQVRDGAVAVSFTVTNTGEVSADEVAQLYVRAEAPSVPRPRRELLAHRRLTLAPGASDRVSFEVPLSALAFWDVAHDRWRLEPGPYALLVGASSEDVRLTTTVTIDGEPAVPRPVGARGVQAVDFDEQSGTEIVDRTKAAGDAVAAVSGRTGELLYRDCDFGAGAAGVTVSVAGAGSVEVALDGGPAVAVLSPDAPTAGPYDYVELASAFTAEGVHDLRVTLRGALRLAHVGFSG
The following text describes a protein:
Function:
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
Miscellaneous:
MISCELLANEOUS: [Isoform 7]: Contains 6 ANK repeats at positions 196-226, 230-259, 263-293, 297-326, 330-359, 363-393.
Subcellular Localization:
Apical cell membrane. Cytoplasm. Synapse. Postsynaptic density. Cell projection, growth cone. Cell projection, dendritic spine. Note=Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Present in the dendritic spines of cerebellar Purkinje cells (By similarity). Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells.
Domain:
The PDZ domain is required for interaction with GRID2, PLCB3, SLC9A3 and CFTR.
Sequence:
MKSLLNAFTKKEVPFREAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNAGAPEWAVCSAATSHRSLSPQLLQQTPSKPDGATKSLGSYAPGPRSRSPSLNRLGGAGEDGKRPQPPHWHVGSPFTPGANKDSLSTFEYPGPRRKLYSAVPGRLFVAIKPYQPQVDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSKKLFRHYTVGSYDSFDAASDCIIEDKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTAELEELGLSLVDKASVRKKKDKPEEIVPASKPSRTAENVAIESRVATIKQRPTSRCFPAASDVNSVYERQGIAVMTPTVPGSPKGPFLGLPRGTMRRQKSIDSRIFLSGITEEERQFLAPPMLKFTRSLSMPDTSEDIPPPPQSVPPSPPPPSPTTYNCPRSPTPRVYGTIKPAFNQNPVAKVPPATRSDTVATMMREKGMFYRRELDRFSLDSEDVYSRSPAPQAAFRTKRGQMPENPYSEVGKIASKAVYVPAKPARRKGMLVKQSNVEDSPEKTCSIPIPTIIVKEPSTSSSGKSSQGSSMEIDPQATEPGQLRPDDSLTVSSPFAAAIAGAVRDREKRLEARRNSPAFLSTDLGDEDVGLGPPAPRMQPSKFPEEGGFGDEDETEQPLLPTPGAAPRELENHFLGGGEAGAQGEAGGPLSSTSKAKGPESGPAAALKSSSPASPENYVHPLTGRLLDPSSPLALALSARDRAMQESQQGHKGEAPKADLNKPLYIDTKMRPSVESGFPPVTRQNTRGPLRRQETENKYETDLSKDRRADDKKNMLINIVDTAQQKSAGLLMVHTVDIPVAGPPLEEEEDREDGDTKPDHSPSTVPEGVPKTEGALQISAAPEPAAAPGRTIVAAGSVEEAVILPFRIPPPPLASVDLDEDFLFTEPLPPPLEFANSFDIPDDRAASVPALADLVKQKKSDTPQPPSLNSSQPANSTDSKKPAGISNCLPSSFLPPPESFDAVTDSGIEEVDSRSSSDHHLETTSTISTVSSISTLSSEGGESMDTCTVYADGQAFVVDKPPVPPKPKMKPIVHKSNALYQDTLPEEDTDGFVIPPPAPPPPPGSAQAGVAKVIQPRTSKLWGDVTEVKSPILSGPKANVISELNSILQQMNRGKSVKPGEGLELPVGAKSANLAPRSPEVMSTVSGTRSTTVTFTVRPGTSQPITLQSRPPDYESRTSGPRRAPSPVVSPTELSKEILPTPPSAAAASPSPTLSDVFSLPSQSPAGDLFGLNPAGRSRSPSPSILQQPISNKPFTTKPVHLWTKPDVADWLESLNLGEHKETFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMNIERALKQLLDR
The following text describes a protein:
Function:
May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MDAGSQGKSILRSNPIFPPQVLPSTCSMAPLFLCLLAALALARVPAAFADALETDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVHYLRPPPSRRAVLGSPRVKWTFLSGGREAEVLVARGLRVKVSEAYRFRVALPAYPASLTDVSLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFAGAQEACARIGARIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVVDPDDLYDVYCYAEDLNGELFLGAPPDKLTLEEARAYCRERGAEIATTGQLYAAWDGGLDRCSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQPSAIPEDYNPVSDPASDRLEAIVTVTETLEELQLPQEAVESESRGAIYSIPIVEDGGGGSSTPEDPAEAPRTLLEFETQSMVPPLGSSEEESEALEEEEKYKDEEDKDQEEEEEEVEDDALWAWPNELSSPEPEASLTTELALEESVSQASPPARAVLQPGASPPPDGEPEASRPPGVLGPPAETLLTPREGNLASAPPSTPDGAREVGEETGGLELSGVPRGESEETGSSEDAPALLPATQAPEGTRELEAPSEENSGRTVPAGTSVQAQPVLPTDSASRGGVAVAPSSGDCVPSPCHNGGTCVEEEEGVRCLCLPGYGGDLCDVGLRFCSPGWDAFQGACYKHFSTRRSWEEAETQCRMYGAHLTSISTPEEQDFINNRYREYQWIGLNDRTIEGDFLWSDGVPLLYENWNPGQPDSYFLSGENCVVMVWHDQGQWSDVPCNYHLSYTCKMGLVSCGPPPELPLAQVFGRPRLRYEVDTVLRYRCREGLAQRNLPLIRCQENGLWEPPQISCVPRRPARALRPVKAPEGHQGRLLGHWKALLTPPSSPAPGP
The following text describes a protein:
Function:
May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase.
Sequence:
MHRPNFRPPTPPYPSPGIGGWGGGNNFRGALGGGPRPPSPRDGYGSPHHTPPCGPRARPYGSSQSPRHGGNFSGARFGSPSPGGYPGSYSRSPAGSQHQFGYSPGQQQTYPQGSPRTSTPFGSGRGREKRMSNELESYFKPSMLEDPWAGLEPVSVVDISQQYSNTQTFTGKKGRYFS
The following text describes a protein:
Function:
Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPAHHKVPKKKSRDGLKPHKNFKKDRKIKQKSEDTVVSEGLPLQIDDDVPDFPRGGGRVLSRQEIDEVRAEVDAEFEVEERGSRKKKKQQQKKSYATENDLGSLFGDGITGKLPRFANRVTLKNVSPGIKLWGVIAEVNQKDLVVSLPGGLRGLVRVNEASDLVSDGDIKDAESNLLSNIFYVGQLVSCIVLQVSDDKVEEKGKRKIWLSVRLSLLHKGLTLDVIQEGMVLTAYVKSIEDHGFILHFGLSSFTGFLPIKREADGGEIKLNSGQLVQGVVRSIDKSRKVVYLSSDTDVVSKCVIKDLKGISLDLLVPGMMVNARVQSTLENGIMLSFLTYFTGTVDIFHLQNSFPATNWKDDYNQNKKVNARILFIDPSSRAVGLTMNPHLLCNKAPPANVKAGDIYDSSRVVRVDRGLGLLLEIPSIPVSTPAYVSISDVADGEVRKLEKKFREGSQVRVRVLGFRHLEGLAMGILKASAFEGSVFTHSDVKPGMVVKAKVIAVESFGAIVQFSSGVKALCPLPHMSEFDIAKPGKKFKVGAELVFRVLGCKSKRITVTHKKTLVKSKLGILGSYADATDGLITHGWITKIEKHGCFVRFYNGVQGFAPRSELGLELGCEAAAIYHVGQVVKCRVISAIPASRRINLSFILSPRPSMGDSVELGSLVSGVVERLTPTAVIVHVSGKGYLKGTVLTEHLADHQGQATLMKSILKPGYEFDELLVLDIDGSNLVLSAKYSLINSAKQLPVDLMQVHPHLIVHGYICNIIEAGCFVRFLGRLTGFCPKNKATDDGRANLFETFYVGQSVRSNILNVDIELGRITLSLKQSSCFSMDASFMQEYFTLEEKIAKLQMPESENFDSNWVKSFNTGTIVEGEIHETKEFGVVLSFKEHTDVFGFIAHYQLCGTNLEIGSTVRAVVLDISVAEHLVDLSLKPEFICGIEEEGSKSRTSKKKRKRVASADLEVHQTVNANIEIVKENYLVLSIPEYSYAIGYASTIDYNTQKLPQRSFVNGQSVVATVAALASPLTSGRLLLLLKSLSEASETSSSKRAKKKSSYKVGSLVEAEITDIKPLELRLKFGIGFRGRVHITEVNDHHFVEDPFSKFKVGQQLTARIVAKFNQSEKNRKACQWELSLRPTLLSGASELEDGVITDDFNFSIGKLATGYVVKVDKEWVWLTVSRHVKAHLFLLDSSCEPSELIDFQKRFYVGKAVSGHVLNINKEKKLLRLIPHPLSIVSNATLGNKITKKDDPESIISNEFVTEHIHEGDVLGGRINRILPGVGGLLVQIGPHLHGKVHFTELADEWLSNPLLEYQEGQFVKCQVLEIIRSTKGLLHVDLSLRATSLEGIQSPKSVGLNNDLNSLISRVKRIEDIHPNMAVKGYVKNVTSKGCFIMLSRKIDAKILLSNLSDGFIENPEEEFPVGKLVSGKVLSVEPLSKRVEVTLRTENTSSASKIDMCDLSSLHVGDVISGRIKRVETYGLFIIIDPTNLVGLCHVSELSDDHIDNIGSKYRAGERVMTKILKVDKERQRISLGMKNSYLSDDTSVDLLNRNIDENKHENGLVDDPLVSISQERSACGIQDSDPDYGSRECEVLAQAESRASILPLDVNLDDVDGSDLDNAVNRAEEHDNETATISEKNKRRAKRKAKEERELEIRAAEERLLEKDIPRTSDEFEKLVRSSPNSSFVWIKYMAFALSVSDVEKARSIAERALSTINIREENEKLNIWVAYFNLENEYGEPPQEAVMKTFHRALQYCDPKKVHLALLNMYERTEQYNLADELLNKMVKKFKHSCKVWLRRVQSLLKQGKDGVQSVVSRALLCLPKNKHIKFVSHTAILEFKFGVPDRGRSVFEEILREYPKRTDLWSIYLDQEVRLGDADIIRALFERAVSLRLPPKKMKFIFKKYLEYEKSCGHEERVEYVKRIAIEYVENSLA
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus.
Sequence:
MADLYTSLPDQYLKNAPEIGDPTTYIQKLLLKELPRSDSQQLRHDLKWQFLLDKHQSSQKRKKPIRKKKTFLTRRERKDLNILKLPKSDWDYNSLEGIRKMWRQYMRQNLELAGRAPHCSEQDWANFSAVLAKSELIGSEIKVARSKCPSHVGLTGTVVLETKMTFQIVTQQSQLKIIPKNTSVFEFVLDAMKFTVFGKHIMTKPSERSVKKIKSVMLPDL
The following text describes a protein:
Function:
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of asperfuranone, a probable antitumor agent. The polyketide synthase afoG is responsible for producing the 3,5-dimethyloctadienone moiety from acetyl-CoA, three malonyl-CoA, and two S-adenosyl methionines (SAM). The 3,5-dimethyloctadienone moiety is then loaded onto the SAT domain of afoE and extended with four malonyl-CoA and one SAM, which leads to the formation of 2,4-dihydroxy-6-(5,7-dimethyl-2-oxo-trans-3-trans-5-nonadienyl)-3-methylbenzaldehyde (compound 2) after reductive release and aldol condensation. AfoD is the next enzyme in the biosynthesis sequence and hydroxylates the side chain at the benzylic position of compound 2. After benzylic hydroxylation, a furan ring is formed after five-member ring hemiacetal formation and water elimination. AfoF and afoC are proposed to oxidize the R-diketone proton and to reduce the unconjugated carbonyl group, respectively, to generate asperfuranone. Since no intermediates could be isolated from afoF and afoC deletants, the sequence of these two enzymes is not fully understood. Moreover, since afoC deletant still produces a small amount of asperfuranone, other endogenous oxidoreductases might catalyze the same reaction with much less efficiency.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MADHEQEQEPLSIAIIGGGIIGLMTALGLLHRNIGKVTIYERASAWPDIGAAFAFTGIARECMQRLDPAILSALSKVAQRNPHDKVRYWDGFHPKSKEEAQDPEKSVLFEIEEKNMAYWACLRGVFHAEMARLLPERVVRFGKRLVAYEDGGDQKVVLRFEDGEVEEADIVIACDGVHSTARRVLLGAEHPAANARYSRKAVYRALVPMPAAIDALGTEKAHVQIAHCGPDAHIVSFPVNNAQIYNVFLFTHDSNEWTHGHTMTVPSSKEEILSAVENWGPHIKELASLFPEQLSKYAIFDQADHPLPYYAAGRVALAGDAAHASSPFHGAGACMGVEDALVLAELLEKVQNGSAFKEKKSNIELALKTYSDVRIERSQWLVKSSREMGDLYEWRYEDIGGDGVKCKAEWERRSRVIWDFDVQGMVDQAREAYERAVVKV
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
MACAHPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAASELAGHQTSAESWGTGRAMARIPRVRGGGTHRSGQGAFGNMCRGGRRFAPTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSTGHRIEEVPELPLIVEDKVEGYKKTKEAVLLLKKLKAWNDIEKLYASQRMRAGKGKMRNRRRIQRRGPCIICNEDNGIIKAFRNIPGITLLNVSKLNILKLAPVGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMRKMINTDLSRILKSPEIQRKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKAAAAAAALPTKSDEKAAVAGKKPVVGKKGKKAAVGVKKQKKPLVGKKAAATKKPAPEKKPAEKKPTTEEKKPAA
The following text describes a protein:
Function:
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
Sequence:
MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIREYGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSNKEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKTSGTIKKFRAGLSIFSPIPKSPSFPIIQDSMLKGKLGVPDLRVGRLMNRSISCTMKNPKVEVFGYPPSPQVSGHCKNIPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSMLKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQWIISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENWHSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYNRMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYEDGQVGDANINTQDPKIQKEIMRVIGTQVYTN
The following text describes a protein:
Function:
Transmembrane protein mainly expressed in brain astrocytes that may play a role in transport across the blood-brain and brain-cerebrospinal fluid barriers. Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. May function as regulatory protein of membrane protein complexes such as ion channels.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Endoplasmic reticulum.
Sequence:
MTQEPFREELAYDRMPTLERGRQDPASYAPDTKPSDLQLSKRLPPCFSPKTWVFSVLMGSCLLVTSGFSLYLGNVFPAEMDYLRCAAGSCIPSAIVSFTVSRRNANVIPNFQILFVSTFAVTTTCLIWFGCKLILNPSAININFNLILLLLLELLMAATVIMSARSSEEYCKKKKGSMSDGTNILGEVPFPARVLKSYSVVEVIAGISAVLGGIIALNVDDSVSGPHLSVTFFWILVACFPSAIASHVTAECPSKCLVEVLIAISSLTSPLLFTASGYLSFSVMRIVEMFKDYPPAIKPSYDVLLLLLLLVLLLQAGLNTGTAIQCVRFKVSARLQGASWDTQSGPQERLAGEVARSPLKEFDKEKAWRAVVVQMAQ
The following text describes a protein:
Function:
Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Subcellular Localization:
Fimbrium.
Sequence:
MKRAPLITGLLLISTSCAYASSGGCGADSTSGATNYSSVVDDVTVNQTDNVTGREFTSATLSSTNWQYACSCSAGKAVKLVYMVSPVLTTTGHQTGYYKLNDSLDIKTTLQANDIPGLTTDQVVSVNTRFTQIKNNTVYSAATQTGVCQGDTSRYGPVNIGANTTFTLYVTKPFLGSMTIPKTDIAVIKGAWVDGMGSPSTGDFHDLVKLSIQGNLTAPQSCKINQGDVIKVNFGFINGQKFTTRNAMPDGFTPVDFDITYDCGDTSKIKNSLQMRIDGTTGVVDQYNLVARRRSSDNVPDVGIRIENLGGGVANIPFQNGILPVDPSGHGTVNMRAWPVNLVGGELETGKFQGTATITVIVR
The following text describes a protein:
Function:
May be involved in signaling events that underlie chemotaxis via the chemoattractant-mediated pkgB phosphorylation.
Sequence:
MNTIDTVVPEMNPALSESIVFAPIRTGEEGEKIPIIPINAALSESIVFSPIPPPPSTTDNTTNTTTTTIETTATDNTNDTEEKQENIENNNNNNNSSISSPNSIDGANKKDSIELEEDKEHSIKRKDGSLGDVVDNEKIIPNSLDSDAPEETSNLNKKSEINIKQVLKNPSFDATNDNHNPQEVDNTDNPDKPTTPRQTTTTTTTTTTTTSTNSTSNKLPNNGDNTVSFDEKFDPNVSHSNLNDDYKASGSSDSPNRVRLNTSQRLKMYKQKSEKRLSHRPKSIKLEHKKNVLGEIIYKGHPSWALMLNIQTGIRNAVGKSMGTEGGVNAKTPQQYHTLRKPSEFKRKEDFYVSPKTQRFESAGTAMTNAHSTGAFKFKDYCPNAFRYLRYLFGIDTADFMVSLCNTLKNGENALRELPTPGKSGSLFFFSHDMKFIIKTIPKDEAKLLRDILPSYLEHIQSNPNSLLPRFFGLYRVKPHSGRQVRFVIMGNLFPTKKKIHERYDLKGSVVGREASVDEKKSDSVTFKDIDFRNRKQKIFLGPGKKQSFIDQIKRDCKLLQSLNIMDYSLLIGIHYPHRENEPPSPSLLRSTLEDSSDFESPSMEQSSAGQQQQQRGSGNYDNSGAGRDSTTGGAAPKENDEIYISAFQQDEGGIKSQGGDTEEHYFLGIIDILMLYSLRKKVEHTYKTLKFGAKQEISSVSPDEYSERFQEFLSTIIE
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MSNRQLSSSDSRNTCNLLSQYFSGKASLKDLQKLGTNGKGETIATKDLLTNIGESSTKTTEKDQKFIDPAPKSATTKSSSEMEIPNKEQKAAQLSIFYGGKVVVFDDFPAEKARAMMLLARRGISHNTCAIFQTTNIDKTAPEINGANNFDLPIARRSSLYRFLEKRKDRGTARAPYQMHNLLPSSSRNGGDQFDLNF
The following text describes a protein:
Function:
Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose, which is produced as an extracellular component for mechanical and chemical protection at the onset of the stationary phase, when the cells exhibit multicellular behavior (rdar morphotype). Coexpression of cellulose and thin aggregative fimbriae (curli fimbrae or fibers) leads to a hydrophobic network with tightly packed cells embedded in a highly inert matrix that confers cohesion, elasticity and tissue-like properties to colonies.
Miscellaneous:
MISCELLANEOUS: The genes bscA, bcsB, bcsZ and bcsC are constitutively transcribed but cellulose synthesis occurs only when DgcC, a putative transmembrane protein regulated by CsgD, is expressed. Cellulose production is abolished in E.coli K12 / MG1655 and W3110 due to a premature stop codon in bcsQ.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
There are two conserved domains in the globular part of the protein: the N-terminal domain (domain A) contains the conserved DXD motif and is possibly involved in catalysis and substrate binding. The C-terminal domain (domain B) contains the QXXRW motif and is present only in processive glycosyl transferases. It could be involved in the processivity function of the enzyme, possibly required for holding the growing glycan chain in the active site.
Sequence:
MSILTRWLLIPPVNARLIGRYRDYRRHGASAFSATLGCFWMILAWIFIPLEHPRWQRIRAEHKNLYPHINASRPRPLDPVRYLIQTCWLLIGASRKETPKPRRRAFSGLQNIRGRYHQWMNELPERVSHKTQHLDEKKELGHLSAGARRLILGIIVTFSLILALICVTQPFNPLAQFIFLMLLWGVALIVRRMPGRFSALMLIVLSLTVSCRYIWWRYTSTLNWDDPVSLVCGLILLFAETYAWIVLVLGYFQVVWPLNRQPVPLPKDMSLWPSVDIFVPTYNEDLNVVKNTIYASLGIDWPKDKLNIWILDDGGREEFRQFAQNVGVKYIARTTHEHAKAGNINNALKYAKGEFVSIFDCDHVPTRSFLQMTMGWFLKEKQLAMMQTPHHFFSPDPFERNLGRFRKTPNEGTLFYGLVQDGNDMWDATFFCGSCAVIRRKPLDEIGGIAVETVTEDAHTSLRLHRRGYTSAYMRIPQAAGLATESLSAHIGQRIRWARGMVQIFRLDNPLTGKGLKFAQRLCYVNAMFHFLSGIPRLIFLTAPLAFLLLHAYIIYAPALMIALFVLPHMIHASLTNSKIQGKYRHSFWSEIYETVLAWYIAPPTLVALINPHKGKFNVTAKGGLVEEEYVDWVISRPYIFLVLLNLVGVAVGIWRYFYGPPTEMLTVVVSMVWVFYNLIVLGGAVAVSVESKQVRRSHRVEMTMPAAIAREDGHLFSCTVQDFSDGGLGIKINGQAQILEGQKVNLLLKRGQQEYVFPTQVARVMGNEVGLKLMPLTTQQHIDFVQCTFARADTWALWQDSYPEDKPLESLLDILKLGFRGYRHLAEFAPSSVKGIFRVLTSLVSWVVSFIPRRPERSETAQPSDQALAQQ
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTLASAPAATESCNSFIPPSFDVNKVEIISDRPDCATFIFTDEDHTLGNALHYVLMKNPKVDFSGYSIPHPSDNRMNLRIQTKSNITAQESLLQGLTDIKDISRHIFETFNNALDQ