lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
Subcellular Localization:
Cytoplasm.
Sequence:
MKDKGKLVIWPAYIDQTRSRSNGRIISRKNAVKEPHLNEIKDAAKNLGLNPEVEPEKAYPKSWWEVSGRVLVDDRGPKSVIAKQISLEIRKKRGKGVPAKT
The following text describes a protein:
Function:
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
RKCVLHHRRPAVGNEKSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQAIQEKHFKKQVGQTIKEDNVSNKTAVQEGGLLLESLNGFALVVSADGMIFYASSTIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMNPPQMSSGQQLQTETGEEYILSKLFKAQENDSTTTDYSSFLTRCFICRVRCLLDSTSGFLTMQFQGKLKFLFGQRKKSSSGTVLPPQLSLFCIVVPLLLPSMTEMKMKSLLVKAKHKADDAAALNTNSSSKTNSGLCEAAELYGRNNHHEAKNNGENGISLVKVQTNEDHWVWVQANSQLLYRSGCSEYMLTQQQMLKEEDEQRKIPSGFASLKGNLEGLSYNGAIETLGQWKHLNWRAVKNEQDNVKVKFEPHTNGECFMQEEPLSSNTSVLGVQNNCTTNSSWALRNSSSCSMSQRMNTCPNRRAGSFYNRDQSFLNLASACPSHWGSAESCESYSGVQQRCAENYTMDHLKLQRPLISSESLYDAAFPLEMPIKTEYDSDAENIADNYLTSQNRAWLDENGSVRKQVFSYPNRVHLKTEPDLCEPASPCQKPRHCLYTPHNWQCIVASHPNNLNLNRSCKGSRSKEVVPFCPQNSSGCLESMPDLPHTACYRHFYSPSPGEEKEQNNEVFKMPCEFKNPYLVQAIKREPLDSPPLSNSGQNRVHMSFPENALAGPVPHKTTECTFLQ
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MSTPNDRSAVRKELREIMQEIQAKHELLSNPDNDEIINFVDKAGKIFDKIDHPREAALDAECFTITSGVTLEKSQRLKTGFKMYDISSFITHFRDLYSENNDITENQLIKFGKEVLLSGWKVAPSNPLIHGIIIERKTRERKKTIKSDVGEAIKPKTVNADEWSAAKETPERIKMIKELLTKKGEMPFFQFVLNVKSFGQTVENIFYTSFLIKEGTAFIVVKNRVPYISISTSKKDSKKQENNSQTVCTLEYEMWKEMVDAVSPNFVQIIPHREVSKDALKAIEQYNTQKFYDSRFLSQPPSTRTSFLKRRKQD
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Sequence:
MAANQSIKELMAAETKASKIISEARQERGERLKQAKLEAEAEITAYRKQMERTFQMNGNTDLMGDDPSMLEEETQRDIKKMQGEFQQNKQSVITMMGQHAVRVQLRVPEARKA
The following text describes a protein:
Function:
Small polypeptide acting as a regulatory molecule which coordinates cellular responses required for differentiation, growth and development, probably by restricting polar cell proliferation in lateral organs and coordinating socket cell recruitment and differentiation at trichome sites.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MAGLKRKFNKGHAFTSKCVSLVKEQRARLYILRRCATMLCCWYIHGDE
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.
Subcellular Localization:
Nucleus.
Sequence:
MAAMTDVTDPSSVAMESATEKIIILPGHSADLTSVTFQIQKEDHTLGNSLRYVIMKNPEVEFCGYSIPHPSEAKMNFRIQTAPSTTAVDVLRKGLDDLIDLCDAVTEKFTEQLPRDTSTTMEVDG
The following text describes a protein:
Function:
May regulate responses to pathogens. Required by to respond appropriately to bacteria during vegetative foraging.
Domain:
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence:
MPSLFSSLKFFCFSPTKDTSDKKIKDEILKKIEVNGGTVQYCIQKFSTNYIILCNGLDEYDRDQHYYNFQSNSLLFLEKSKSLGIPILSYKFINDCIGKNLIINDLQGYKISNIIDETIIKFEYQEPEEEIKEIQEIQEIQEIQEIQEIQEAYDDFFDLFGLDSAPIADGDVFKNMPPISQVLAEKAKEEKENQEKQEKERQEKEKKEKEKSKFKSTYISDRKLAMNQKTSPTTTSYFDNEIDDKENINNNDDDFDIDEIDFNLFSNIDLEINEKPIEEDFNLFNIGHYDDNVNRNIKTKSKFDNLNNKIKNNGYIFQFVNKDVSLYHEKDFPNNFKSIKLFEQSSKGLSCMITEDNRCYIWGNIKSNQKVEQLADHYQVDYCSVGGSHSVMIKRGIHTVGLNKFGQLGYKNGNTNCIGGGGNNKLMIENQIQRSISIINQNFLKKVLMVSCGKDFNVLLTNEGQVFSWGKNDQGQLGLGNSDSKENYEIKLVNFDDPYDSNSNKFISFISCGGNHSIAIESNSSTDGNCRLYGWGSNSQGQIGEKYSSVPILIKNQDQKSFNWKSPLVLCTQDTTIVVETPLKCTTFGVKFNSFLMNLKENFQDLTQFDIVVLKKRIGVLVYDEYLKASFLLRSLNYNENYHYQLIKLIIESNKFQHSHAVKLAKDCCEYGNLKVFKLLEHKFPLNLIDPVTLESPIHYSTLFNNNHLKSKIILEYCLINKIYSIDQLNKQKETPLHYCSRFGNYEIATILLVRGCNRNLKDVQGQTPLHISVSQTNHQLSSLLCKHGAQSIPDKTMKNPLQYCSADIKSNLQNILFTNEVFISYAHKDSEFVNNLRSNFGLFSLRCWLDEYRLQAGCNWRAEITRGVVNSDVVVFVISETSINSLWCRKELKMSKKLGKVIIPIFLQSVQIDPILYGLFTFIPKTTKKTFKEMSEKEVISNVSSISNLIHSILNGTQDSKLLTIQQQQQQNFEKSVQSLSRKEFFDKCYLNDKNSGCYLLFNNADRILFDFICDKFKENSIPTISSDEIIGRPSDQDDQFSLFNLMKQKKQNSIQRKKNIELEKKLKLENDEKLKQQWKIKRKIEKKLEKSKLIPSDPNYQYLENYLIQLYNFKNDNENEINENENNNNNQNNQNNQNNIIQNNYNYNNNNNYYDDNDIPILNNNFNSSELNNNYFSSSTTIQIEDSYNNNNNQAIYYDDGKTSEEEFYKQLLIEKENEKYHSIQPLKEFIKNSLLMCILFTRKTTKTEIEKYCLQIEYAKSFKDEKGNQDKTIIVITPDLSLKDNQNTPSIIKDLVWYEIDSKNIDLIFENITLMYEVLEKTLQISNLVNNNK
The following text describes a protein:
Function:
General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI1 (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=According to PubMed:11535589, it is an integral membrane protein, while other authors showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles.
Sequence:
MAAQKDQQKDAEGEGLSATTLLPKLIPSGAGREWLERRRATIRPWGTFVDQQRFSRPRNVGELCQRLVRNVEYYQSNYVFVFLGLILYCVVTSPMLLVALAVFFGACYILYLRTLQSKLVLFGREVSPAHQYALAGGVSFPFFWLAGAGSAVFWVLGATLVLIGSHAAFHQMEPADGEELQMEPV
The following text describes a protein:
Function:
Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MGCGLRKLEDPDESSPGKIFSTLKRPQVETKTEFAYEYALLDFTLQASTNPDVIKINSVLDIVAKVEDYYLKGYVVGAIHPVIQPVGQRKHLPASHLYRAVLSRLKLSPKHSAAGGQRRARLVMEECPLTCEAQANDAAKELMDKINAAAKRGMKFVGLVSQCYLPSMHCNGASHDGVAESGLHVRQDSQDNCKGWNEGALGGHLSESGVEEEPQHESGQHQTERNSSPSYANPKRGEAPDGKLYMVFNAFEEDAASWAYQEGVLSMKVTRKGAVISALDANWLELTTFYYKQGFSLIDSFVCWETPKGDQLPKSLEGFFIYEEEGSGVPGSNRRGNDAIVVEQWTVIEGCEIKTDYGPLLHTLAEFGWLLTSVLPTPILRHDSEGNLATKQVVFLQRPVTWNSAAQTPERKGSRLLKGEDRNKVSSRSLGLDTNASQAAGGRAPLEEGSLSPSRECWTKEERPAQSDSFSGFSSSDSVLRELDDGQFDQEEGVTQVTCM
The following text describes a protein:
Function:
May be involved in vasopressin signaling in the kidney.
Subcellular Localization:
Cell projection, cilium. Cytoplasm.
Domain:
The SAM domain mediates homooligomerization.
Sequence:
MSELSDEASEPELLNRSLSMWHGLGAQVSREELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQQMVKFLLESGANANVREPVYGFTPLMEAAAAGHEIIVQYFLNHGVKVDTRDHSGATARMLAKQYGHMKIVALMETHSPVLPKSLYRSSENYEDLSSSDESWPVPQRQRPCRKKGLSIHEGPRALARITATGLGGKTPDSYEQVPPRGYVTFTSSDENTMEGEGLCYRDVTSPINERDVESSSSSSREEPTFCASLGPVWRSSSSDGLARAQGLSSEASIESNEDSDHARKSSVRKQTRTYLKNKSRHNNSDGHWPSSTGTARTPGSEPQAEKSPYSGPQDLATLLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSSARPPSDALELAYADRLEAEMQELAIQLHKCCEEAEALRGQVSQEQELRAVVESCLLEQDSARKDIHAQLQEAQTLAQDAALVLDQLRACQAELSARLKQHHSPSEATQNPPFLPADSKGWPIPLQALSLPELSGALEDRVHEMGIMLRNAEPGETTDAEWEEMEGTIARRDDSDVG
The following text describes a protein:
Function:
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Subcellular Localization:
Cytoplasm.
Sequence:
MPHAIPKLDLVSSWRDIQFPPLKNDLLLRAASGEETPRAPVWVMRQAGRYLPEFLEVRKHHSFFECCQTPSLASALTLQPIDRYPRLDASIIFCDILVVPQALGLEVLMEPSRGPVLPNPLVTPDDIKRLRKDVDVQKELGYVFEAVTLTRKGLDGRVPLIGFCGAPWTLMAYMCEGGGSKTFEKSKSWLYKYPEASHELLRRIADVCADLLIGQVLAGAQMLQVFDSWAGELTPHQFKTFALPPLLHISSKVHSVLSQLSHPGVRITLFAKGANTPSTFSLLSDPAQTGYATLGLDWTVDPVEVREIVGKKVNLQGNFDPTVLYGGKEGIEKEVERLSARWKEAGGGWIANLGHGITPNVKPEDMGWFLECVHKYSERK
The following text describes a protein:
Function:
Component of the histone chaperone network. Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy. May also bind and stabilize monomeric H3. Maternal effect gene essential for early embryogenesis.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, perinuclear region.
Sequence:
MSAEAEAIVTTATADVSSPSKTVAVEPVAADTTPDNAPAVSTEGSGKAEQERAEKILKGKELFSQGSRNFLVKSYDEAADELSQVCQLYEEVYGELADELGQPLLLYAKALIAMALDENKVIDVPDEAADDDDEDVDDDEEESAEDGAAKKEEKKDTKEAANGASSSNGKELDTIKEGSDEADSTGEAEQAQSDEKPSKKVPTGVDEVSSSNGGGGAAVNDDERPSTSNGEVTASCSNGAAPAVEEEPEEEEGVSGSLQLAWEILEAAAQIFSRQGLSGLPYLAEVQTELANIEFENGILEAAREDYEKALKIHGELPTRNRRALAELHYKIGLTYLMQQLNKEGATALRQSSVLIEEEIAEIKGKDEPSERDRNNMLDLEETKQEILAKIQEIEEMQAQTIAEVRAALDSYIKPMSSGDAAAASSSSSSSANGAASSSSSSSKGAAAASSSTISSSSAKPTDITHLIKRKKPEDPSSEAEALCSPAKRAAV
The following text describes a protein:
Function:
Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEHQQLRKYVELYNKEVEEFYNGAASGRPAEFHPSKVHVKSIHEKAGTANAGVEISSVGVDWDSEEKNTFFWCLSRYSIHRVDEWRSLLPRKSAMEILGYYRLLRRASASARSRKAGDDGAPIAYEMSAEWVALETKLSETVMAITEGAAEVADEEGHCEGLIDYESWKRRWVAIYSHSRIAEIRPLPRHALPLSRSATQTLERCVSRYTRTLLWCTALAGMASRSVSARAAESRGHKSLPTVVTRRQVERALCTEARSRDLHVLPRRIVLTLRKWELDYPREGKLFRTKEMAHLFLQSQLSRRDAPPVHQDENQENQENQENQEQDNTASEGESEAERDEIDEADLFRSALHENQLLKWLSK
The following text describes a protein:
Function:
Probable transcription factor involved in somatic embryogenesis. Acts as a positive regulator of BHLH109.
Subcellular Localization:
Nucleus.
Sequence:
MVKETVTVAKTCSHCGHNGHNARTCLNGVNKASVKLFGVNISSDPIRPPEVTALRKSLSLGNLDALLANDESNGSGDPIAAVDDTGYHSDGQIHSKKGKTAHEKKKGKPWTEEEHRNFLIGLNKLGKGDWRGIAKSFVSTRTPTQVASHAQKYFIRLNVNDKRKRRASLFDISLEDQKEKERNSQDASTKTPPKQPITGIQQPVVQGHTQTEISNRFQNLSMEYMPIYQPIPPYYNFPPIMYHPNYPMYYANPQVPVRFVHPSGIPVPRHIPIGLPLSQPSEASNMTNKDGLDLHIGLPPQATGASDLTGHGVIHVK
The following text describes a protein:
Function:
Essential for recycling GMP and indirectly, cGMP.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTFSVFNFQFSIKQMTGKLIIFSAPSGSGKSTIINYLLTQNLNLAFSISATSRPPRGTEKHGVEYFFLTPEEFRCRIENNEFLEYEEVYKDRYYGTLKEQVEKQLEKGQNVVFDLDVVGGCNIKKYYGERALSIFVQPPSIEELRCRLTGRGTDEPEVIECRIAKAEYEMTFAPQFDRVIVNDDLEAAKAETLEVIKEFLNKE
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion membrane.
Sequence:
MAAKVAMVAVPTVLGIASIRVYRTNEEPVDGLVPRSKLNIYTPLPDSAQATFVPESPGVIERGVSVTRQSIVPLVQAVKDACVYVKKGSVNIYHGGEDVYYYLIEPPPEFLPRFGTITMAGLLGMFLARKGSRFKRLAVPLGLMSAAASVCYPAQAVAALKVTGKKVYAAGRWSGAVASSLLASKKPVSTEILASQPQAATEPNPESAQDASLQSPVITESDMSAPASYEPVVAVTTEEDSSGTLTEISTHQPPTEPSSGSFGDSLPGETLISPPSDESASPARSEEELNEKQAFDDDSAESTAYTQTEATEEVPVESSSEISADVESRPPPSGTSDPETSDAPSDPAGDSTEPVIESEPQQSSTQQPATESSKGTTTTSFLFCFLCHMFSQTNKKEPQTSLLCQNVEK
The following text describes a protein:
Function:
Transcription factor required for gene expression specific to photoreceptor cells.
Subcellular Localization:
Nucleus.
Sequence:
MVHTEEHSNAFTLEFNQIHEGGAMYISCGSTDSTPMEPETGYVPNNPLFGMPLDSPQECPSSCGGSGCSSCQENTASLPLAGLHGSDFSDCGNCLDHSGVLSSQSNLGSYWSEDMSTFPGLPPLDIDPLPSLFPFSPCGASYNRPERPTHDVADVLLSLKHAVLKQSPDPPPIGQGQSFATPQASLSYTVHPQMLLSPASHHGHGSHAHYNQMPSQTGGPYSTNYYDSSCAQHSAPPMYPSMSVNVSMNMTMHGYGAEASVPMQCSQMQWGAQNAASSVNVLYPPLLSPVPYPPGTTYSFTADFRPQSQPPPPPASGGSLSPLAHDSSRSSSTMTPQKQVLPQAQAQHLQQHQQQQQTLQQQQQQQQQQHQQQQLQQHQYYQHAHHAHHHPQQHQQQQQHHHHHHHHHSQSGSAAVSPNADCTPPKSTTPPDFGTVVDHQSTPPTTTTSAAAVAVAAASAVGFAAALKMKAESRVLGLGFADTVDQRTAAIGEDDEEEDGSGSGSDGAAGGDSKPNLCRLCGKTYARPSTLKTHLRTHSGERPYRCPDCNKSFSQAANLTAHVRTHTGQKPFRCPICDRRFSQSSSVTTHMRTHSGERPYRCRACKKAFSDSSTLTKHLRIHSGEKPYQCKLCLLRFSQSGNLNRHMRVHGNNGQALIT
The following text describes a protein:
Function:
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQTSWLRSVRIKTLKRRRLSGRRQMDPVASSCMRSPHPPAPGWGCLRNPHSEGSGASGLPHYPPTPFSFHQKPDFPATATAAYPDFSASCLAATPHSLPREERIFTEQHPAFPQPPDWNFPVSEARRRLNPGPAGGSRGMGASSPGLVDTTGGPGEDYEVLGSTASEMEKKSSRRKKESSDNQESRGKPEGGSKARKERTAFTKEQLRELEAEFAHHNYLTRLRRYEIAVNLDLSERQVKVWFQNRRMKWKRVKGGQPISPSGQDPEDGDSAASPSSE
The following text describes a protein:
Function:
May play a role in synapse assembly and function.
Subcellular Localization:
Cell membrane; Lipid-anchor. Postsynaptic density. Synapse. Membrane. Cell projection, axon. Perikaryon.
Sequence:
MKAVVRVLKLEERAVHRQQNRPPAVQGSQHQSHSPACMNPALMSSPWVRQKHGGRAIPNRLCLSTTDSPHSYRYQDDDSPPPEHSFPRLTNEVRAPELVHVSEKNLSEIENVHGYVSHSHISPLKASPAPIIVNTDTLESVPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNESDVSEVSHSKAVEALKAAGSIVRLYVRRRRPMLETVTEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEAVAILKNTSDVVYLKVGKPTSVYLSDPYGPPDITHSFSPAMENHISSPGNNGTLEYKSSLPPISPGRYSPLPKHLLGEEDINRNPSLDEMEGHRFDSQHFQLREPRKIVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDQILSVNGIDLRGATHEQAAAALKGAGQTVTIIAQYRPEEYGRFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRALFDYERAKDSGLPSQGLSFRYGDILHVINASDDEWWQARRVTPEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGSLDSKGSFSEKRRKNFIFSRKFPFYKNKDADEQDGSDSERSQEELILSYEPVIRQEINYARPVIILGPMKDRINDDLISEFPDKFGSCVPPANSSDQEDTTRPKRDYEVDGRDYHFMASREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVKYVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSIESLMEMNKRLTEEQAKKTYDRAMKLEQEFGEYFTALVQGDTLEDIYNQCKMVIEEQSGPYIWIPSKEKL
The following text describes a protein:
Function:
Metalloprotease.
Sequence:
MLYTTDISLFFVILLNLCTVSIAVKQSWEINQDLVTNENKEHTVFGDMLLTPAQLLRYENSKDSDLTIRGVSIKGNSNNRWENNIVPFVISPQYSATQKKILISSLRYFERVSCFKFVDRTTQNDYLFIVPLDGCYSYVGKIGGRQALSLAADCIADYIIWHEMMHAIGFEHEHQRPDRDSFIRVDYSNVIPGQMINFDKLQQSQVEFPDSYDYKSIMHYDGYAFGRVDGVRQVRLATMIPLKPGVRLEDNMKFTATDIEKLNRLGQCGTRGGQYSNQGVVAATCKDVATAISCEGNRRVRSGNAAYTVILNSELQRGMCKNPFYKQMMIKSCQKTCRLCSYARSIDEDENLTPNTTRKPLKCEDKHPRCDVYSQNGFCSLPFYDDVRYQLCAKTCNLC
The following text describes a protein:
Function:
Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.
Subcellular Localization:
Cell membrane. Cytoplasmic vesicle. Lysosome lumen. Lysosome membrane; Peripheral membrane protein; Lumenal side.
Sequence:
MTDIKQASAMLKWLRVVLRVLLVIMVLMTGRLLYSRVSYSTLTKRQMDLHNDAQTAQGSSVQRSPRSSNAGVSLSVVHDIVLWTSHRRGEVGIFRVPVLTYTPKGNLVAITEGRRKSKSDENPKVFAVKRSTDGGATWSPSQWIVDDGMSRFKRCSYIGTIFVDDTTATIFLMYVFCEFCPTRSLMLMNSTDDGITWGRPRNITDQVGKEHATHPSPGYGIQKKHDPAKGRLIVCGHGFHDGKGLVLLLSDDHGVTWRHGAFVPSVPFLNIQKGHFDPDECQPVEFPDGSVHIVVRNQMVYKCNCKMIMRSFDGGETLPRQYMLLDRTLIEPRITSGVWLHNGTMFYSGPNTRLKRSKLYIRWSHDFGRTWTSGTEIWGDLAGYSTFTMLPQDNDHIYMLYERGTTEYFDEIAVTKLKISSSTTHDPR
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MRTFSGRKERQGPAPDVPEAAGFDGRTTERQAAAEPGRHLGGSSPRPRFRSGWRRHFRAGLGGGRAQDGGGGGCAQAQWRPSLRPPPRAAVAAAMAAMSLLLRGSAALWGPRLLPRPRFHAFLVGRSPGTRAPVRHSGGHGKKMFIIKPSHFYDNRFLNLLKFYILLTGIPVAIIITLVNVFIGEAELAEIPEGYVPEHWEYSKHPITRWITRNFLESPERNYERTLNILQIESEKADLRLKQLEIRRLMRQRGDGPWYYYPTIDKELIDYSPKSTPDN
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MLSSRFCSVLCVHSTCTWNRSSKANLACVSASVGTSPLRPQPSLSRGWILQHKRGSAGTGIEEVLLSTLEEPRSELELQAIENGKELEISESLRISGIEMEKGMRLVPEAKYVRGADIKKESFIRVYYISALRVPAKDCHELERNLDEHLLNWPRVDNIARVRGDDVDHDLENLFRGSKEWSPSTAQAIRSAIYGEEGAINEEAILSNKDLKLVESGVKGMDDQLSPTSIRCQPYTVEVVDEQANANASGGLLGILKKKWTGPTRLLLLNEELVGRSFAELPPSIKAVLSRSEECESQSRCQLVSCRLTLYYEYWSLEEVLKDLLPSEVEVPDAFERIGHVAFLNLNAEQCQYRHLIAQVTLDKHQPRVRSVVNKREARNTRSYAVHVEVLAGTSSLVTTVWENGIPFRIDLASVIWDSRLRADRQRLVGLFCRNDVVCDVFAGPGPVSVPAGFKVRRTFANEVNPVAYKYLAQNVTANKVASKVEVFNLDTSQFLENVFDPERPSPVTQVVMAYPSAAADFLDFFCGAFKRRTWELPFLPKLHLYTFSSGADPAKRVSQDIENTFGVCPKDMDVVLIAEEAPGEWMLRASFTIPPEVGFR
The following text describes a protein:
Function:
Involved in the response to variation in environmental oxygen levels by inhibiting hif-1-mediated gene transcription in a vhl-1-independent manner. Plays a role in susceptibility to killing mediated by P.aeruginosa and by pore-forming toxins produced by B.thuringiensis. Probably by preventing hif-1 transcriptional activity, regulates behavioral responses, such as locomotion speed following acute reoxygenation. Plays a role in normal egg-laying probably by regulating spermatogenesis and in body morphogenesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSSSPHTHTLIIMERLSEVRLYSSPMTSVLNSNLSSCLTNAFIPDTVRMASSPLLAWMTLVVIGTLAPVSVFSCLSLKRSVKELLTERSSKLDVLDIFRFVAILWVMLNHTGSEGRIDILDRLPSADAFKSAMHDHPIFGALMGNSALGVEIFLVLSGLLAARSWLRKADEPFFQHWKSFIARRLLRLAPSMFIFVYIAAGPIMNALLPRYSSSMVSACGFWGILSHVTFTSNWQSTPTCMGYLWYLGLDMQLYMVAPIFLNLLHKFPKRGMALTITTIIASMVIRAGYCTAYGTCNQSDVDIPFISYPGQDAETLKSIYAGLWDMYSRPYTKCGPFLIGLLLGYITVSSKYIMVSTTSKTLFRSSLIVAIATIYAILPEYWNPNAGNTLYNTVYTAVFRSVFAMAISGMIAALYFRQEYRPTNPIFAMLAKLTYNAYLLHMPVVYIFNWLPFLQAATSPIHLLLVLPFVAILSFIAALIFYLFIEAPIGHLTSQYATRLGL
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MSLKLQNIKGSGGGSGGNRRKLVASSTATAATLLLVALLVAIPWTSAAAVENDQNSNNRNLNLDSSSSFGAAPSNQNDIYIDDEGLEGSGSRGEVRDDLEKEDDEASGSGFGDDDEDSTSSRSSLSSSSSSGGNLNVLRGGSDNLPGSGDHDDNDLYTDTNLPTVDPSTTDDEDMPIGKDNSKSSSSSSSSGSSSSGGVYSRGGEIIETGENDLDLGGLPRHHVTPTEGSINHHDNTQYGAGSGVLIMNAKNDDRTASFFAQPGILAAVIGGAVVGLLCAILVVMFIVYRMRKKDEGSYALDEPKRSPTANTYAKNVNNREFYA
The following text describes a protein:
Function:
DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single-stranded DNA.
Subcellular Localization:
Nucleus.
Sequence:
MDRPGPGSARPGRTVHVWGYRVEWKVRNGRKLQPSEWAGRGDLGGFKRRWKDTRATVGTTFRRRSRVSLVGELSKFPLPSDSSGGKSSSSFARGALAWCRQRNPNPSCAAAETGARTSLPKERCRGWRLGNWLHKHPHPNTCPRLPACWLPPILTERGERVPKLVPLLACYPKSKPKD
The following text describes a protein:
Function:
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type II membrane protein. Note=Anterior acrosome in non-capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction.
Sequence:
MVSALRRAPLIRVHSSPVSSPSVSGPQRLVSCLSSQSSALSQSGGGSTSAAGIEARSRALRRRWCPAGIMLLALVCLLSCLLPSSEAKLYGRCELARVLHDFGLDGYRGYSLADWVCLAYFTSGFNAAALDYEADGSTNNGIFQINSRRWCSNLTPNVPNVCQMYCSDLLNPNLKDTVICAMKITQEPQGLGYWEAWRHHCQGKDLTEWVDGCDF
The following text describes a protein:
Function:
May inhibit gastric epithelial cell proliferation.
Subcellular Localization:
Secreted.
Sequence:
MKHLVASSILGVFVLTPSLAMMNIRFNHPLYGSFGTQIIHIGAFQGMVSIRDNNIFSEWDGILDYKNALLVAKVFNKMACVLARMDKAVFPSLDDISKALDKQAFKYYPSTRGLTYTVLPSWVKNLAQYGKPIKNMCRDDPTYFAQQQKEGTALAIDSNSCFEIQLLSFMGLFICGETPGL
The following text describes a protein:
Function:
NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.
Sequence:
MAASQQFPTYNEQSFPPTEENMATVSSSTPRSPHKLVEQVIRTPGRQPSPQPTHFNVPHRNGNGNGHRVLRSATVGYVAPEFKGRTEQMSKVREQIKAMKWIPEELIDAQLEWFYNELGIDDVYFQTESVDAVVSNITSLYAAKVAAFAREDKRQEIRLDMESSDHAIYIDTSEPGISAIGGPRYEHRLEAKYLDTSSNQSFRVESFRSTSNLYSGPTPTKSSIRCYFVYQSQFVDSNPSPSETRLEVISDRMFLAKSTKNTKQIYQEIIELAVSRTGPVIEVFDIEDSNEKRLVVAFRRRTALGLFSALSDLYHSYGVTSSRKYVEQFSNGITVMSLYLKPASNLSGNFPTLEQSIHQITKEISLLYCIPQNKFQALFASGRLSLQETIYGHCVWVFVQHFLNRLGSEYSSLVSALDPLNSSHAEILSTIKRRLRTETFTSDYILEIISNHPELVRSLYASFANTHLTLAPGFSEDSIPPSPSGDVLNDRELKELISRTVSNEHEDMVMTAFRIFNNSLLKTNFYTPTKVALSFRLDPSFLPEIEYPQPLYGMFLVITSESRGFHLRFRDIARGGIRIVKSRNREAYSINARSMFDENYGLANTQQRKNKDIPEGGSKGVILLDANQQDKASVAFEKYIDSIMDLLLPPSSPGIKNPIVDLYGKEEILFMGPDENTADLVDWATEHARKRNAPWWKSFFTGKSPKLGGIPHDSYGMTSLGVIVDPQGLNIDELKRLATKRAMISDVNKLIKDGKSTIPYIVEGANLFITQDAKLRLEEAGCILFKDASANKGGVTSSSLEVLASLSFDDEGFVENMCVGNNGQAPQFYKEYVKEVQETIKMNAELEFEAIWREHEQTGIPRSTLSDTISVAITKLDEELQTSDLWRDAKLRKSVLLDALPQLLLSKIGLDTIMQRVPENYLRAIFGSFLASRFVYEVGSSPGQFAFFDFMSKRLANVRPRSPSL
The following text describes a protein:
Function:
Responsible for the addition of alpha-(1-2) mannose branches to the linear mannan core on the biosynthetic pathway to mature lipoarabinomannan (LAM).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSAWRAPEVGSRLGRRVLWCLLWLLAGVALGYVAWRLFGHTPYRIDIDIYQMGARAWLDGRPLYGGGVLFHTPIGLNLPFTYPPLAAVLFSPFAWLQMPAASVAITVLTLVLLIASTAIVLTGLDAWPTSRLVPAPARLRRLWLAVLIVAPATIWLEPISSNFAFGQINVVLMTLVIVDCFPRRTPWPRGLMLGLGIALKLTPAVFLLYFLLRRDGRAALTALASFAVATLLGFVLAWRDSWEYWTHTLHHTDRIGAAALNTDQNIAGALARLTIGDDERFALWVAGSLLVLAATIWAMRRVLRAGEPTLAVICVALFGLVVSPVSWSHHWVWMLPAVLVIGLLGWRRRNVALAMLSLAGVVLMRWTPIDLLPQHRETTAVWWRQLAGMSYVWWALAVIVVAGLTVTARMTPQRSLTRGLTPAPTAS