lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
Subcellular Localization:
Cytoplasm.
Domain:
The PRC barrel domain binds ribosomal protein uS19.
Sequence:
MRQDDLKLLGKIVTTHGIRGQLKVASFSGEFDTILSLETVVLKGKDGRMETFPVARATVHHDRVLLSLTPFTNINEVLHLISAVSYAHRDQFPPLEEGEYYWCDLIGLQVVTAAGTVIGRLDSILPTESHDVYVVRGADREYLIPAVEDVVVQVDLEAGTMTVSPPEGLLDL
The following text describes a protein:
Function:
Seems to regulate utilization of fixed nitrogen by controlling the expression of a certain gene(s) involved in nitrogen metabolism.
Sequence:
MRLEQLQAFLKVAELGSFQQAALQSEVTQSTISRQIQGLESALKCQLFHRGAQAKLTVAGELFLRRARKICQEWDVASEEISSLFQGKQTELCVAAIHSVCVSSLPSLLPKFCLGHPQIQLRVTALGSDRALKVLQDGLVDVAIIMSHRNLTNTKELAIKPLYEEQICILMASDHPLTTKKFITWENLGPYPQVIFKDGYRMRRLVEDEFSRREIPLNVSLELNIPEAFYGVVQGSEMIALMPQSLVTPVIDNPNFSVRYLFCPESGDRQDFRRQVSVVTTVDRLQIPPVAEFFNLVVDHYRCGALTVK
The following text describes a protein:
Function:
Highly specific for beta-cyano-L-alanine (Ala(CN)). Low activity with 3-phenylpropionitrile (PPN). Not associated with auxin production but may be involved in cyanide detoxification.
Sequence:
MALVPNEGPLFAEVEMSGDSFSSTVRATVVQASTIFYDTPATLDKAERLLAEATSYGAQLVVFPEAFIGGYPRGSTFGVSIGNRTDKGKEEFRKYHASAIDVPGPEVDRLAAMAGKYKVYLVMGVIERDGYTLYCTVLFFDSQGHYLGKHRKIMPTALERIIWGFGDGSTIQVYDTPIGKIGAAICWENRMPLLRTAMYAKGIEIYCAPTADSREVWQASMTHIALEGGCFVLSANQFCRRKDYPPPPDYVFSGSEEDLTPDSVVCAGGSVIISPSGAVLAGPNYDGEALISADLDLGEIVRAKFDFDVVGHYARPEVLSLTVKDHPVSAVSFTSTSSTSKAERSTK
The following text describes a protein:
Function:
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of medium and long chain fatty acyl groups from lysine residues. Has weak NAD-dependent protein deacetylase activity. Regulates the endonuclease activity of ALBA3 by deacetylation of 'Lys-23'. Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis. Cooperates with Sir2B to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versions of the erythrocyte membrane protein 1 (PfEMP1) molecule, to evade the detection by host immune surveillance. Involved in recruiting ORC1 to the telomers and subtelomeric repeat regions (TAREs) and promoters of var genes. Can ADP-ribosylate both histones and itself. May also have a role in telomeric end protection.
Miscellaneous:
MISCELLANEOUS: The reported ADP-ribosyltransferase activity of sirtuins is likely to be some inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Chromosome, telomere. Note=At the late ring stage/early trophozoites, co-localizes with ORC1 to telomeres and subtelomeric regions (TAREs) in the nuclear periphery. Spreads out from the telomere over a distance of at least 20-40 kb and is an important component of the heterochromatin complex around Rep20, a region that lies adjacent to the regulatory 5'-UTR element of telomeric var genes. May relocate to the cytoplasm during the multiple rounds of DNA synthesis and nuclear mitosis in trophozoite stage.
Sequence:
MGNLMISFLKKDTQSITLEELAKIIKKCKHVVALTGSGTSAESNIPSFRGSSNSIWSKYDPRIYGTIWGFWKYPEKIWEVIRDISSDYEIEINNGHVALSTLESLGYLKSVVTQNVDGLHEASGNTKVISLHGNVFEAVCCTCNKIVKLNKIMLQKTSHFMHQLPPECPCGGIFKPNIILFGEVVSSDLLKEAEEEIAKCDLLLVIGTSSTVSTATNLCHFACKKKKKIVEINISKTYITNKMSDYHVCAKFSELTKVANILKGSSEKNKKIM
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
VITVCELFTNELSKFLHAEADDQLNETLQTKYLNALKMNIYLLTQMIDSYLSLSRKEDRENSTTTKNKKSSKAKSSTALGIDWESECQRSVHILMSVFDLDIHRLWNAQLVEDELTSLVCNLCFKILEDPTMVKSKLVKSSVLNLLGCIIKKHNQSLSASLKVVQMLQHFDHSATPMAEAVHMWASTYKCRSIVSEVLRELSHIPERDFIRDSSSTKTICSFIVELSYYLPDAVLLNISLLLPRMDEESYMMRNSVLGAVGEIIIQCLSKEGLDEKSKQARDQFLDILYDHANLDVNAFVRSRALHVWLNLVSENSLPVKRCPDLVELCVRLLLDKSNLVRKVSVQLLEALLRKNPFRDNVRNIYHVEGFSILKSGVHNPILVIFINPKQKPDSLFPKLTISPLQCSLKQEQEKLEELQSIQAYWFKPKHESKFVGKIEKRSNKIKLTKQNIIFLAFSHVFNEKNEENKSKENEEILEEGMQEDDVEKNDENGSGSEEEQTENEKQDLLKTQEPNLEIEKKKEIIEYLSNAINFVERFNDAVPVLCQLLNSRTQSDVVEAINFFTAAWEFQLGCALEGITGMLEQIWNEDQKIRDAVVSAYRKLYFKTDSNITSKVKTVNVADNMIKLVAGSSNAKLPAIECLIGEIQKSGDWPSAVAQICWDRLTNPLASFAIVTGLSEMKQRKVSIQLLGMLANKDANVIKSKIKTLVSVGLKERTLPTSENVFDFELPFHTCVALSKLAAKKTEAGKYMRQFRYPDDHQLITTLTSLVVSGFNKKSVMWVKFALEAVGVIFQLSDNPVVVSTSMLNEIKGVVHARLSSDEPSGEIPVNELLMRFYSIIGQFALKLLVFIEGDVQSEIKQNRKLQEENEEADKNAQKKNKSSGKDDSHLEDDMGVGGATADDADQEFIKNVLETEIVEPDTPLGSLSEWLVRCCTVVVEPSDHSAVRVQQTASLALAKFMLVSSKFCERHLRLLFTMLEQSPHEGIRANLTIAAGDLSVRFPNLLEPWTSHIYARLNDKSVMVKVYATKVLTNLILNDMIKVKGHVSEMARCIVDENEKISAIAKRFFQELAKKGNSMYNVMPDIISRLSDPDIGIKDEVDFKKIMRFLLEYIQKDKQTESLIEKLCHRLEATRDKQQRRDLAFCLSILNYTEKGVKKLYDNFSLYANVLRDEQVYFLFNNILTKCKKCAKPDVKSQVDELEGKIIDRHACDVSEDECAAKAAEAVRSRKP
The following text describes a protein:
Function:
Cytochrome c2 is found mainly in purple, non-sulfur, photosynthetic bacteria where it functions as the electron donor to the oxidized bacteriochlorophyll in the photophosphorylation pathway. However, it may also have a role in the respiratory chain and is found in some non-photosynthetic bacteria.
Subcellular Localization:
Periplasm.
Sequence:
QDAPTGDAAAGAKVFNKCQTCHMVVAPDGTVLAGKAGKTGNPLYGLDGRAPASYPDFAYGDGIKELGAAGEVWNEADFLQYVADPTKFLKTKTGDTKAKGKMTFKLPNEKEAHDVWAFLNSLAPAPAAAEAAPAADAAAPAAADAAAPAEPAAEGAAT
The following text describes a protein:
Function:
Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTKLVEWLGGAGLFAGVWAYLFISTPVGNSSDFARHFVLFLPFYVLLAFAVISVSIIAWRVYTFNDCEEAAKELKQEIADAKADLIKKGFKLD
The following text describes a protein:
Function:
Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA.
Subcellular Localization:
Mitochondrion.
Sequence:
MAPAASLVCARLPWWRLRPSVPFALRRGYSAMCVDDMINGLNPEQKQLRETMFKFFQEHLVPKAHEIDQNNEFPDLRKFWKQLGNLGVLGITAPAQYGGSDLGYLDHVIVMEEMSRASAAIGLSYGAHSNLCVNQLVRNGNEAQKEKYLPKLISGEHIGALAMSEPSAGSDVVSMRLKAEKKGDYYILNGTKFWITNGPDADVLIVYAKTDPVAVPVSRGITAFIVEKNMPGFSTCKKLDKLGMRGSNTCELVFENCKVPVSNILGHLSKGVYVLMSGLDLERLVLAGGPLGIMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLTTSRQYVYNVAKACDEGHHSPKDCAGVILYAAESATQVALDGIQCLGKSTACPAQQPNVSSSSSCQGSGPKLKMLPGALVLLGPRHEGGTREGWGDYYSGSQLGSPLCRHTSRAACSYRRMGNKKQHHLCWSGHPDTLALLATPPSPPAPALGPGDGRKNGYFPPILFSLKSSHPFLLQVAMDTLTISLWDAFFEMPNYMKLGLGQVRFGG
The following text describes a protein:
Function:
Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRRLAARGAAGDAGEVAAPAADSSDSAQGRSPSSWRLIDLCAVWDAGVYLPSAAWNGASSGVARRRLNEAERLSSVREAQLKRLKVTRPRVLGSRERGRVPRMARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSVKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAKRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDDNNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAVNEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYPDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMTGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAPPTLPPTTVGATGAVSSTDATAIAATTEATTVPIIPTVAPTTIATTTVATTTTATAATTTTESPPTTTSGTKIHESAPDEQSIWNVTVLPNSKWANITWKHNFGPGTDFVVEYIDSNHTKKTVPVKAQAQPIQLTDLYPGMTYTLRVYSRDNEGISSTVITFMTSTAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA
The following text describes a protein:
Function:
Involved in regulation of group size of aggregation streams.
Sequence:
MRNEEAEKLFWIFNNKVRPINYSEIVENTTPRKSSINREKIESENNGQVYNELFFFKLLLNEDLSKFLISLINTNLRHEREKKLDKGKDISRLNDLTDITFWKFITDYLKNIYSNKNNDKIPPELINLKMMDHNRYSAVHNVLDMKSHRFEEYCEIFMNSALKYINIGNVLNCDETIYAYYGKDAIKDHILINNDSKPHSVGIEAYSLTTKLNISNCPYVISYGPRTPENCQSPFNSLKTLLDNLHSKYNWEDPRNNLIVCCDSAFALVNNKECLDELKCRILSSTRKSGVTVPQEIKIFVKPLLTIHKTFLFYDESTGLLYEYTKNTAGHINCIATNLYSRYSNPYVEINNNLNIEQFATIGNLFRFSKKELELIFVGETLHGTTLEILNGKYKTNFVKPPCGPFWNEQMLKKLSAEHIAQIYNDKYKKENNNLNKNDKIKKILEPLDSTQDGGIYDKNKNYSKKELQDLKIKVIGTHQNRSQMIHDQYIFWYNLVDITDKRYYATIRGSSSHSYTKLFILGGLFDLILNSYSLHREYHEMELECKNPENQPPEIIQTINKFVESLIFQFHELKELQ
The following text describes a protein:
Function:
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
Sequence:
MTIELTPGGLLIAIEGIDGAGKTTLARSLATLLEQAGARVVLSKEPTNGPWGTQLRQSAATGRLSAQDEVDLLLRDRREHVEALIAPALARGEIVILDRYFPSMVAYQGAAGLPLDALLAANDFAPRPDLLLLLDLPPPTGLARIRARGDAPNHFETQDNLERCRAIFAALQLPGKHVIDASADADSVLRQAHAVVVAALADRLRVGATHTDAEKAALELLSAGRPA
The following text describes a protein:
Function:
Antimicrobial activity against Gram-negative bacterium E.coli.
Subcellular Localization:
Secreted.
Sequence:
ALFSILRGLKKLGNMGQAFVNCKIYKKC
The following text describes a protein:
Function:
Accessory subunit of the minor fimbriae. These filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome. They play an important role in invasion of periodontal tissues and are recognized as major virulence factors. Fimbrium subunits from different strains have highly divergent sequences, and this correlates with pathogenicity (Probable).
Miscellaneous:
MISCELLANEOUS: The name (minor fimbrium subunit) does not indicate the abundance of the protein, but is derived from the greater length of the major fimbriae. In strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, major fimbriae are 300 - 1600 nM in length and about 5 nm in diameter. In contrast, minor fimbriae are only about 80 - 120 nm long. This length difference is observed only in a small number of strains, including strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, and is due to a loss of function mutation in FimB, a protein that restricts fimbrial length in other strains.
Subcellular Localization:
Fimbrium.
Sequence:
MMKRYTIILAVFLLFCTVFTFQIKARPYERFADVEKPWIQKHSMDSKLVPANKGNLIQAEIVYQSVSEHSDLVISPVNEIRPANRFPSHRKSFFAENLRASPPVVPVAVDKYAVPVANPMDPENPNAWDVTLKITTKAVTVPVDVVMVIDQSSSMGGQNIARLKSAIASGQRFVKKMLPKGMATEGVRIALVSYDHEPHRLSDFTKDTAFLCQKIRALTPIWGTHTQGGLKMARNIMATSTAVDKHIILMSDGLATEQYPVKNVTTADFIGETGNANDPIDLVIQGAINFPTNYVSNNPSTPLTPNYPTHSSKVGRRNLPESKFDYSNLSARITFDGVAGALVYEPRFPHPYYYYFPCNAAINEAQFAKNSGYTIHTIGYDLGDFALANNSLKLTATDENHFFTATPANLAAAFDNIAQTINIGIQRGEVTDFVAPGFIVKNLTQSGDVTHLLNVSNGTVHYDVSTKKLTWTTGTILSSSEATITYRIYADLDYIQNNDIPVNTTSAIGPDLGGFDTNTEAKLTYTNSNGESNQQLIFPRPTVKLGYGVIKRHYVLVNKDGQPIQANGTVVSSLSEAHVLQSQDFFLPSGGGHIVPKWIKLDKTTEALQYYSVPPTNTVITTADGKRYRFVEVPGSTPNPGQIGISWKKPAGNAYFAYKLLNYWMGGTTDQQSEWDVTSNWTGAQVPLTGEDVEFATTENFGSPAVADLHVPTTNPKIIGNLINNSDKDLVVTTNSQLTINGVVEDNNPNVGTIVVKSSKDNPTGTLLFANPGYNQNVGGTVEFYNQGYDCADCGMYRRSWQYFGIPVNESGFPINDVGGNETVNQWVEPFNGDKWRPAPYAPDTKLQKFKGYQITNDVQAQPTGVYSFKGTLCVCDAFLNLTRTSGVNYSGANLIGNSYTGAIDIKQGIVFPPEVEQTVYLFNTGTRDQWRKLNGSTVSGFRAGQYLSVPKNTAGQDNLPDRIPSMHSFLVKMQNGASCTLQILYDKLLKNTTVNNGNGTQITWRSGNSGSANMPSLVMDVLGNESADRLWIFTDGGLSFGFDNGWDGRKLTEKGLSQLYAMSDIGNDKFQVAGVPELNNLLIGFDADKDGQYTLEFALSDHFAKGGVFLEDLSRGVTRRIVDGGSYSFDAKRGDSGARFRLSYDEEWVESAEVSVLVGTVGKRILITNNCEHACQANVYTTDGKLLIRLDVKPGSKSMTEPLIDGAYVVSLQSPATSSNVRKVVVN
The following text describes a protein:
Function:
Plays a role in innate immunity by conferring resistance to virulent strains of the Gram-negative bacterium P.aeruginosa via the zip-2 pathway. Can act independently of several immunity-related pathways including pmk-1 p38MAPK, dbl-1 TGF-beta, kgb-1 JNK and bar-1/beta-catenin pathways.
Sequence:
MHTKVYVSEDRTKVFVLFYEAACVFSNFYPSGFEAKPVENFLKDTEKKEKLLKFTCSEQYFMYNKALLVGDMDIAEQILKETNPMKMKLLGRKLSMTKEQLKLWSQKSKDVMYRACLEKFSQNEDCRMILFRTHGMKLVEASPTDKIWGIGLDKADQRCEDERNWRGSNWLGEVLDQVREELWTRQEFKSNREQILKESLETRCQILEHFSH
The following text describes a protein:
Function:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Subcellular Localization:
Nucleus.
Sequence:
MMHEQCDEAKSKRNLIPKQSTLQYITMTSTLSTTKNHLVILPPTTKPTIVSLTHPRTRNLARFVVDSSDPKHTKVYEITQINGSNAHFEGTPDPRSIILQVEGDKGSVIQDPSVFMTTPFSPLWLILPTLVRHKDKLMTLDDLHEASCHGVDRMDLITQDTFDKYIPDVCEVMDEGEKFYKLSNEKLLAHLKAIVASIKKSLPNDIYVRHVQNLLDSDASDEIKDLAKEHISMNMLGSNLPPDVTEILLKSVDFEPYNKHKAEYKAKRDAESAAQGPSGPPEKKRKKSAPAKEEKAPKNNKRLTAFFSVVPKK
The following text describes a protein:
Function:
ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability. Furthermore, CTP functions as a weak affinity agonist for P2RX1; Receptor for ATP that acts as a ligand-gated ion channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGLKMKEKVSNFLFEYDTPRMVLVRDKKVGLTFRMIQVGVLAYIIGWVFVYEKGYQNVDGIISSVSVKIKGLAVTDLPGVGTEIWDAVDYVFPPQGDSSFVVMTNFITTADQKMGYCNELPDVAPCETNDDCKITAFRQSQEETNDPSMGLSGVMTGNCTTYDNKTKSCQIYAWCPVENDYTVPKPPLLSQAENFTLFIKNSISFPRHEVTRQNLVESVTSSYLKKCIYHKETDPLCPVFRLGYIVEQSGRNFSELAYKGGTISIVIDWQCDLDWPVRYCKPIYEFHGLQDENKVSQGFNFRHARYYKEDGVSKRTLFKVFGIRFDILVNGQGGKFDIIPTMTTIGSGIGIFGVATVVCDLMLLHVLPKRNYYKEKKFKQAKTDQKDSQEKVEVYTYSQNGQQLNSSSSENVYDTQLNTYNSC
The following text describes a protein:
Function:
FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
Subcellular Localization:
Bacterial flagellum basal body. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAAQVGIAPIKQRGVATLGGTEKVAALLLAMGRQAAASVLAQFEPQDIRIVTKAAAELRPITAQELEGIVEEFAQQFSMGANILGTLGGLEAVLGDVLPADQVSAIMTDLLGNSSRSVWDRVSSVSENSLATYLSKEHPQTAALILSKVKPACAAKVMSQLPSSLRNELMRRVLSLKPIADDAMKVLEKTLHEDLTLNFARNLGADTYARVADIINKMERGHIEDMLKSLSEKRPKSAEVLKELLFTFDDVIHLTPKARTMIFDQVPTDRIVIALKGTDKNFRELILSSVASRVRRVVEHELAIGEPSNQRDVLEARRVITDLALDLAEKGEIELNPEQEDELVFR
The following text describes a protein:
Function:
Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.
Subcellular Localization:
Cytoplasm. Golgi apparatus. Endoplasmic reticulum. Note=Preferentially localized to the Golgi apparatus.
Domain:
The START domain recognizes ceramides and diacylglycerol lipids, interacts with membranes, and mediates the intermembrane transfer of ceramides and diacylglycerol lipids; The PH domain targets the Golgi apparatus; The FFAT motif is required for interaction with VAPA, VAPB and MOSPD2.
Sequence:
MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNTLSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQKFFDACADAVSKDEFQRDKVVEDDEDDFPTTRSDGDFLHNTNGNKEKVFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKREDSWQKRMDKETEKRRRVEEAYKNAMTELKKKSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWSTSMPSGDAFSSVGTHRFVQKPYSRSSSMSSIDLVSASDGVHRFSSQVEEMVQNHMTYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHVVETLADNAIIIYQTHKRVWPASQRDVLYLSAIRKIPALNENDPETWIVCNFSVDHSSAPLNNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKTAGKPILF
The following text describes a protein:
Function:
ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.
Subcellular Localization:
Nucleus.
Sequence:
MDDDDFDDIPDEDLMLAFTQATGNITSHHPSNSKQLASSAKPPAQAWPISDSARRIVTPTVSQGQATATGRAKTASKPTTSATTSRPSLAQSSQRKNLRQTTLWGGTLEEDAQPAPQAVSNRPFRADMPPEQPTHHEIDIEEMKTWVYPMNLGPIRDYQFSIVKNGLFNNTLVALPTGLGKTFIAATIMLNYIRWTKTAKAVFVAPTKPLASQQVQACLSIAGIPRSQATLLTGETPPVLREDEWATKRLFFMTPQTLMNDLSKGYADPKSIVLLVIDEAHRATGDYAYVKVVEFLRRFSKSFRILALTATPGSSLEGVQDVIDNLGISHVEIRTEESIDIRQYVHSRDINTITFDPSDEMMEVRDLFSKALKPLVTKLSSQNIYYGRDPMSLTTYGLMKARNDWMAGPGRHVNQGTKFSVIATFAILQSLAHSIKLLNFHGIKPFYNNLAEFRTTEEEKGGKGSKLKRQVLEDENFQKMMDMIEGWMKIDGFLGHPKLEYLCETLVNHFMDAGEGSNTRAIVFSEYRDSAEEIVRILNKQPLIKATVFVGQADSKRSEGMKQKQQIETIEKFKNGAHNVLVATSIGEEGLDIGQVDLIVCYDASASPIRMLQRMGRTGRKRAGNIVLLLMKGKEEDKFNEAKDNYATMQRMICEGSRFTFRHDLSSRIVPRDIRPEVEKKVVEIPLENSQNPELPEPKRSAARMRTKPAKKKFNMPDGVETGFIKASFFGQAGAKTAKPPARPPAPKETDFIAERPKLESILLSTSQENELRRNYTKIPLGHSKVEELDIDWYRHPTSRRVVQKTIHVKHGEYTKRCVKLFRSLAKSQAPANRYTKPYGETDTSSWELIPLPPLADETEGETSRKGQKKRPRLESGQEAEEAEQYAAPKKRQATAKTKSTGVSKQTNKPRARHTALISDCEEGGNEYDGNVDDDEQSRPRNFRSKGRGRGSGRGKKSQPKQGDPNVDYGDDCTRTSDMEMGTDGSDDGADLEDFIVSDGEVTSSLQHRPRGSTSPTTAPDAGSSSLSSKTGRKQQAPDSFASDEDDGDVFGPKFVPVTASAAKGSLPSTARREKPKPFYVPVELPATQDTTDGDDDLPDIEFLSAKRKREGTGTGMRTGSPGHVKVGDTSKGGSGGDQTREKPSGGAASHARARKRTVVMDSDDDQE
The following text describes a protein:
Function:
Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo. Binds via its C-terminal domain to RNA in vitro.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGKSDFLTPKAIANRIKSKGLQKLRWYCQMCQKQCRDENGFKCHCMSESHQRQLLLASENPQQFMDYFSEEFRNDFLELLRRRFGTKRVHNNIVYNEYISHREHIHMNATQWETLTDFTKWLGREGLCKVDETPKGWYIQYIDRDPGTLRRQLELEKKKKQDLDDEEKTAKFIQEQVRRGLEGKEQEAPVFTELSRENDEEKVTFNLNKGACSSAATSSKSSSLGPSALKTIGNAASVKRKESSQSSTQSKEKKKKKSALDEIMEIEEEKKRAARTDYWLQPEIIVKIITKKLGEKYHKKKCIVKEVIDKYTAVVKLMDSGDKLKLDQTHLETVIPAPGKRVLVLNGGYRGNEGTLESINEKTFSATIVIETEKKEKRNVFEEFINLAKLRDGVFLKNSVSFSLWLNHYKVMENLIFPWQSNSPPLFNFVTLCSLDPASCFHLR
The following text describes a protein:
Function:
Sodium transporter that under salt stress mediates sodium exclusion in the phloem to prevent sodium transfer to young leaf blades and reproductive tissues.
Miscellaneous:
MISCELLANEOUS: Substitution of Pro-140, Arg-184, His-332 and Leu-395 in salt-tolerant cultivars indica Nona Bokra and Pokkali confers enhanced sodium transport activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Localizes to the plasma membrane.
Domain:
HKT transporters are proposed to contain 4 pore-forming regions enclosed by transmembrane segments with each containing a potassium channel-like selectivity filter motif.
Sequence:
MSSLDATTPRYDEFKRIYHLFLFHAHPFWLQLLYFLFISLLGFLMLKALPMKTSMVPRPMDLDLIFTSVSATTVSSMVAVEMESFSNSQLLLITLLMLLGGEVFTSILGLYFTNAKYSSKMIATLPDDDDHGGSGKPPPPTTSPSSTLVELELAPPMDVVVVNPTTTATTHDEVELGLGRRNKRGCTCTTTHTSSSSSASKTTTTRLLMFVVMGYHAVVHVAGYTAIVVYLSAVGGAGAVVAGKGISAHTFAIFTVVSTFANCGFVPTNEGMVSFRSFPGLLLLVMPHVLLGNTLFPVFLRLAIAALERVTGWPELGELLIRRRRGGGEGYHHLLPSSRTRFLALTVAVLVVAQLALFCAMEWGSDGLRGLTAGQKLVGALFMAVNSRHSGEMVLDLSTVSSAVVVLYVVMMYLPPYTTFVPVQDKHQQTGAQSGQEGSSSSSIWQKLLMSPLSCLAIFIVVICITERRQIADDPINYSVLNIVVEVISAYGNVGFSTGYSCARQVRPDGSCRDLWVGFSGKWSKQGKLTLMAVMFYGRLKKFSLHGGQAWKIE
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSLYEHAALPLASSPSILGPISGGRNRGNIQLQSIPIEFQAVVFAGFGNSLYPLTGSDALPKALLPIGNKPMLHYPLYWLEAAGFTSAILICMEEAEAHINAWLRSGYEGHMRIHVEAPTILDDSKSSADALRAVSHLIKNDFVCLSCDSIVGLPPIYGLDKFRLDNPSALAVYSPVLKYEHITSQSKEIDAKQLIGIEEKTSRLLYAKSSADVGSDFTFRMSLLWKHPRVTLNTNLSDAHIFVFKHWVIDLIREKESISSIRGDLIPYLVKCQYQKSFTVRENIQRFLSSPNNIDNYDGGLSSQEIKINALIAKDGIICSRANNLPNYFELNKCIAKLTPEQRLVDVTVSERALVGADCMVNEGTTIKDNSNIKKSIIGKNCVIGKGVVVSNSILMDNIVVEDGVRLESCIVASGAQIGAKSKLRECEIGVDHRVEAGRIARGERLVDMEKIETDMD
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTETAFRGTLLLLQNRTRRDPEAYRDEFLTQLDHFKALTQTVATQKETNPQYVAVLNFVCHVGHCYPKECEDVAEIVLKLLQDFKGSTMTSDLRLVLVKSLALLRSKNIVSAERSFPLFFELLQERDKVLRRVILSHIVSDIRRVNMPGAKNGAAVNKKAQNFLFGVMADDDPVQARCAEMVMIDLYRRRVWADERTVEVLTQACFSRHTAIIRTALRFFLLQMPKITSMDSKNEDDDDDDPGRAISKMKQKLKIKKKTGKRERILKREVGAVKRKYNKEEKEEELLAKQHVDPIRLLRNPQQFVERLLARLQKTSERFEVRVLYLNVIARTVSEHEVVHLPLYGFLERYMEPSQLHSTQLLALSVMCTHRMVPPDALEPLVRAIANHFVSDRSSPDAITVGLNTIREICKRQPLAMNADLLKDLVEYKSQRGDKGVVMAARALIQLFRHVYPELLPGKLRTRTVDASTGEAPKPVYGKEHVYTDIPGLELLYADEGSDASSHSCCSGSSDDDDDSDGTWVTDSSDCDPDDIEGSFVDASECSSCDEEHEECPQLVTVKPSSGEPPCKVTKYENNAIGAESQPSFREDMPSQVHKPSNQDSDTPSEESGGSSELEEELEEFEEVEGESYDEEEGDDSDVEEGSEEEGDDSSFCSEEWEDEEEEADEEEDQPSQKGEKDVEGAGEWFEDVDINSTQPSQRSTVSKLSSSAARILTDEDFARIRALQKKQQQGKLLSKRKGKDAEARAKKREALIHSVSADLTAEVIEHFTEKKRTEDRQEKIARTEELRRSKSKFEARKKKKSKLNSTHVEHSKRGKLFNMTKRSRRVGAKLKSSVADRSNRNKENKKKDIKFRIRRGWKA
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGNPYLLLYNAALVLGWGYCLYLTIDTMLLKKGTTADLWQVVELPLKVSQTAALLEVVHSAIGLVRSPVMITAMQVASRIWVLWGIINPEPVLAAGGAVHLAQPLPGVSLPGVPAEVGGMPLALNLATLLTAWSITEVVRYSFFAVKELAGTVPYPLLWLRYSTFLPLYPLGVASELAMVRLALPAIWARHLWSIDLPNSFNWAFDYPILCGLIVLSYLPGLPQLYLYMLAQRSKVLSGGAKPSSSAGKAKRS