lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the heterotrimeric replication protein A (RPA) and holoenzyme telomerase ribonucleoprotein complexes. As part of the RPA complex, binds and stabilizes single-stranded DNA (ssDNA) intermediates, that form during DNA replication or upon DNA stress (By similarity). It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (By similarity). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (By similarity). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation (By similarity). Also part of a subcomplex of the holoenzyme telomerase ribonucleoprotein complex: this subcomplex that contains TEB1, RPA2/TEB2, RPA3/TEB3, but not RPA1, mediates the recruitment of telomerase to telomeric DNA via specific interaction between TEB1 and telomeric ssDNA. In the holoenzyme telomerase ribonucleoprotein complex, RPA2/TEB2 and RPA3/TEB3 act as assembly factors for TEB1 incorporation into telomerase holoenzyme. In the holoenzyme telomerase ribonucleoprotein complex, RPA2/TEB2 does not contribute to ssDNA affinity, while it contributes to ssDNA affinity in the RPA complex.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MSNRVQGGFDNNSGNNQSAQKQQAEKIPQITVPLNCFMINQIVKAAKENPQAHSGNHYEWYGAFENAIITAKFEFLQSINDSPKIMGKLSDSTGCIEVVIQKSKMSDELPEFVQAYEIELQNNGNRHKYVRAMLKMRKNAQIQLLYFSIVNDANEISRHGLDLCLRYLQRKHGIEDFMHMTNDKAHNNHNASAQKVHYQIDRNQQPKEQVLELMRQILKHNPNDQIPKSKIIEFFQSQLNQVQINQILQQLVSANEIFSVGSDNYLLNV
The following text describes a protein:
Function:
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
Subcellular Localization:
Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton, colocalizes with stress fibers.
Domain:
The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12 (By similarity); The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.
Sequence:
MEDLDALLSDLETTTSHMPRSGALKERPPEPLTSPLTQMGPGESSGASGDKDHLYSTVCKPRSPKPAAPATPPFSSSCGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKETAGEQKEDQSEDKKRPSPPPSPSPVLPKPSATSATLELDRLMASLSDFRVQNHLPASGPTPPPVPSSMSEDTPSPPGPTSKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGLCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSGITKPAIRRLARRVGVKRISGLIYEEIRGLLKIFLQNKILDAVTYTEHEEDSDCYGCCLSGKNPLCGCAGVPLEIDESTKIHIFGQLCSHTYRFGFVAANIQQLACGKRRKIAQNSMDLFKDNKENTVTKSHHQELMFIKGREKLVEQSGAMIGSAKQSKEVSTLALDSTLKAGKCSVDFGVNMHHFSDIGAGTAYDVQSDVGRTENLTCNNPEVLNVNLKMLWMVMRTFNNIGSTTGAVPQLTTKVVDKDSQDMNASKIQVNTSAKGSLRPVAGKTTRRTRSITLIWPETLDFASKADVVAANYFPEVGASSAFVVESDSAQHLNHDAVMINSTSALMRSWVAKEQTRRNLVLSNEELYQENSVIRDTRALQIGVSGRMSLPASQQYCINGGTYFLHCHVIDL
The following text describes a protein:
Function:
Putative phospholipase.
Sequence:
MTGYVDDNLKITTAEGVIDKNGTCWAIWDDNLDKNGLMHFNVSGKEGETPIKMMYCAGYLEGVLAQTRIYQAYINNMDAMGMQDGFPQTIRDHYSSNTKYMQEMIDANPNSDYWQVIGGFYNLGQGIIDGYASVAPEDQKISAENLRIHQNFPDIWDIMTAFQQLDPKDPIRAKCTAGIRLLPDYSDVFVYHNAWSDYRNSIGCVIDYDFPLPQFHARHVTLTTLAGLISSLDDFYISDSGLVVFETSLMSQDVQMLKNFINPKSLFCGYRSIYAMFTAHNGTDWTEKFLMHNSGTYNNDYFITDMNKFIRGKKPSKDLVWLVEQLPSEKHYTYDVTGNLTKDGFIASFNVPFSEDLYYVLQYDKVENSSEYYLPYKTHPRYLISARDLPTVKNFQDFKKFSRYNNYKRDPLSRGDPLFAISSREDLLGKAPNGAFNQKAVMGSRAFTNGEFSFCNSPTNEDLPSFTWNSPDFKNVSHIGIPDTLNFTWNEMGATRDDTCHKITDADVCKKSSFCGWCGRTKICMAGNEDGPFYEKCYSGWHSKYTSFKFYIIGIVFIVVLTLVGGIVVAWIIYRRSRSKLNVSDTLLLQQN
The following text describes a protein:
Function:
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
Subcellular Localization:
Cell membrane. Cell projection, lamellipodium. Cytoplasm. Nucleus.
Sequence:
MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEGPVSNQGYMPYLNRFILEKIEYLLKKLTEAMGGGWQQEQFEHYKINFDDSKNGLSAWELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHRRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE
The following text describes a protein:
Function:
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
Sequence:
MRKGKLIVIEGISGSGQQVKAGIVALHNTLVENKYDVVECANPDSGRAKELGITNLLNWPFGRTPRADFLFESAVRTEVFKNVVEPALQQDKIVLCKQSSVSSLANAWVSGYTKHFDVLRHIDKISRGFLFEDEIFPDLTIFIDVPAQEAFERIEDVLQIHHEGGIDYYNQMREFYLKEISRWRGVRIDASAGRHPEIINAEIWDVVKKIL
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Sequence:
MSLQQPCISPYSIALLVLVRLALDHQLYGPLHVSDLGDQHAQSSDSADNSAFTTSQILLFLGDCLDCLDLSENYLGLKYFLNSMDLFRDNEDDLSDQNAKSSPIGLFVNKNIAAFQTLELDGWMVLNQQYEAFCKGESLDDIGNYLNHLRSGEIYRALEDLRRFIDYSVVGDTNKIPFQYVSLNMAAVHSEMGQHMEALEFVSDALRYARFVGDDTCLSYILMWLDRLTWKLGRDTMCNKYGNMPNEEEILDTLAERTQRFGQHQLQVLSHLRNATWRLMNGKSPILVFHSVQIATSLVNHHRGLEALVSTVELTKAGIWEIYGNTQSARAAIQQVLIVNQKEYSANDLSMAYSKNALYEASEGRFKEAFSLIKTAKQRFPIVGFFEASKHWLVAMGYILLDRALFRLNMPLAAHILANLSAHCIDTPHNNQAIKIYGARLAKRYGKRDEAYRLFMEASEPPEEGVIEGSLNYIPAMLEQADLLLEEGREGAIAALPITLKCLALADQYSMNLIRIMGLVRLSHILVHLQYFRQALDLITELLPSVLVAASAVDRGYTYFVHAQILIAAMAGSDRPITGSNATEPFTLLEKKAVDQSVKEATRLAGNNTDKRIVTSTLHSMLTTTWASVIYSLKEAEKCYINLASVYHLERCYHLMSLAYNRAGLIAERNEACKKMRALCIPFEVSDDAENEQYTWEYQIKH
The following text describes a protein:
Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.
Sequence:
MATCCPTRPLFQTSKRLYQSQRRTFLPNPFADTSSPPQTLRAQRVLPYPSAPIYSIIADVPSYASFLPYCQRSDITHWSAPDKTYARRWPSEGKLTSGFGGITESFVSRVYCVPGKYVESVGGDTETSLDRDEIAHHLEAGGSGSRAGGDNGLLRHLRSKWTIEELGKDKTGVSLALEFAFTNPFYAALSGGVAPKVADVMIRAFEQRVMALLKENPEMVGASLAELDGSRMKR
The following text describes a protein:
Function:
Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (By similarity). Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (By similarity). However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (By similarity). Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection. It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation (By similarity). Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection, lamellipodium. Cytoplasm. Cytoplasmic vesicle, autophagosome. Nucleus. Note=Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles. In pre-apoptotic cells, colocalizes with PYCARD/ASC in large specks (pyroptosomes). In migrating monocytes, strongly polarized at the leading edge of the cell where it colocalizes with polymerizing actin and PYCARD/ASC (By similarity).
Domain:
The B box-type zinc finger interacts, possibly intramolecularly, with the pyrin domain; this may be an autoinhibitory mechanism released by PSTPIP1 binding.
Sequence:
MAKTLGDHLLNTLEELLPYDFEKFKFKLQNTSLEKGHSKIPRGHMQMARPVKLASLLITYYGEEYAVRLTLQILRATNQRQLAEELRKATGTEHLIEENRVGGSVQSSVENKAKSVKVPDVPEGDGTQQNNDESDTLPSSQAEVGKGPQKKSLTKRKDQRGPESLDSQTKPWTRSTAPLYRRTQGTQSPGDKESTASAQLRRNVSSAGRLQGLYNNAPGRRESKKAEVYVYLPSGKKRPRSLEITTYSREGEPPNSEVLPTQEETRNGSLIRMRTATLNGRTTGALEKGTGIPEHSMVLDEKTFRNMSSKTSLIGEERCPTSWTENGNGSPETTESSGETAGSILSDPEVPLSLCEKPAKTPEDPASLGQAACEGRSQDKAVCPLCHTQEGDLRGDTCVQSSCSCSIAPGDPKASGRCSICFQCQGLLARKSCEAQSPQSLPQCPRHMKQVLLLFCEDHREPICLICRLSLEHQGHRVRPIEEAALEYKEQIREQLERLREMRGYVEEHRLQGDKKTDDFLKQTEIQKQKISCPLEKLYQLLEKQEQLFVTWLQELSQTISKVRETYYTRVSLLDEMIEELEAKQDQPEWDLMQDIGITLHRAKMMSASELLDTPPGVKEKLHLLYQKSKSVEKNMQCFSEMLSSEMAFSASDVAKWEGRQPSATQVQGLVPTVHLKCDGAHTQDCDVVFYPEREAGGSEPKDYLHPQPAQDTPELHEIHSRNNKRKFKSFLKWKPSFSRTDWRLRTCCYRDLDQAAAHPNLIFSMI
The following text describes a protein:
Function:
Bifunctional diterpene cyclase that catalyzes the successive two-step type-B (protonation-initiated cyclization) and type-A (ionization-initiated cyclization) reactions of geranylgeranyl diphosphate (GGDP) producing successively (+)-copalyl diphosphate and miltiradiene.
Miscellaneous:
MISCELLANEOUS: S.moellendorffii contains two distinct types of functional terpene synthases (TPS) genes, the typical seed plants TPS genes (SmTPSs) and the microbial type TPS genes (SmMTPSLs).
Subcellular Localization:
Plastid, chloroplast.
Domain:
The Asp-Xaa-Asp-Asp (DXDD) and Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motifs are important for the catalytic activities, presumably through binding to Mg(2+).
Sequence:
MAKVLFSSFQQTGISGSLKSGQLSGVFINGTNLKSNAHAKRFRKNSTSSITIRCCASNSPTLENTKLAGAPEKRQKKKQLPYQGILHVPGDRVEELDTRETSLLVAEVKGWLMKLASGKGEISPSAYDTAWVARIASESDSSLPEFPEALEWIINSQLPDGSWGDDRHLQLYDRVLSTLSCLVTLKTWDIGHNSIAQGTKFLRENMIKLKQDDGDLLSGFEVTFPMMLHEAKQLGLDIPYETEFTRLLEISTKKKLAKIPLDKLHSAPTTLLYSLEGLQDLEIDWQKILKLQSKDGSFLSSPSSTACVYLKTKDRKSLQYLQNAMEDQNYAVPCHYPIDLFESLWVVDTIERLGIDVFFRDEIKAVLDYVYSFWTNEGIGWGSTCLVNDIDDTAMAFRILRMHGYNVSPDAFNQFWLPGDKFCCFVGELSHGVSEMLNLHRASQVDFPNEAILTKTFKYSHDYLLNVDSAHMDKWATKKNLMGEVAFELANPFHDCLPRIYNNAYIKHYGMDDLWIAKTIYRLPLVNNKVFLELANRYAQQCQLYQPAELTKLVNWWHSSRFEDIPSTRLTANIDMLPYIYYVICATFHEQEFAQLRVFFSKACCLNTLFDDLMDCATSIEELDRLQNVIERWDISLSHELPLEYRIPFQEFYNTVLVMTEAASKIHKNLSPEFICKYLSGIYTKLIKSEIADARWKIEGYIPSFEEYMENAEVSISTWVHVLMSILFCGEPLTEEILNTIYDSRPLKLDRIICRLCNDIQTYKIEMKLGQPTQGVSCYMKEHPGATEEDALVYLQSLLEKTKRELNESYFITHENDLPKNIKRFNFEMVRMMLITYNETRQVDLFRNPDNELKDMIKFCLETYRTL
The following text describes a protein:
Function:
B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP.
Sequence:
MGQESDIQSVLFDDNHRALQTDIVAVQSQVVYGSVGNSIAVPAIKAQGLRVTAVPTVLFSNTPHYKTFYGGIIPAEWFAGYLTALNERDALRELKAITTGYMGSADQIVLLSKWLMAIRASHPEVCILVDPVIGDTDSGMYVQAEIPQAYRTHLLPQAQGLTPNVFELEMLSGKPCRTLEEAVAAAQSLLSDTLKWVVITSAPGESLETITVAVVTAQVVEVFAHPRVATELKGTGDLFCAELVSGIVQGKKLTTAAKDAAQRVLEVMTWTQQCGCDELILPPAGEAR
The following text describes a protein:
Function:
Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (Probable). Forms heteropentamers with CHRNA9. Expressed in the inner ear, in sympathetic neurons and in other non-neuronal cells, such as skin keratinocytes and lymphocytes. nAChR formed by CHRNA9:CHRNA10 is involved in modulation of auditory stimuli. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, mediates synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (By similarity).
Miscellaneous:
MISCELLANEOUS: The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).
Subcellular Localization:
Synaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MPALHIEDLPEKEKLKMEVEQLRKEVKLQRQQVSKCSEEIKNYIEERSGEDPLVKGIPEDKNPFKEKGSCIIS
The following text describes a protein:
Function:
Has a role in chromatin assembly and chromosome segregation. Involved in the deacetylation of histones.
Subcellular Localization:
Nucleus.
Sequence:
MEQTLAILKNDNSTLVAEMQNQLVHDFSPNGTALPELDIKAFVQKLGQRLCHRPYVYSAFMDVVKALHNEIVDFPGFIERISVILRDYPDLLEYLNIFLPSSYKYLLSNSGANFTLQFTTPSGPVSTPSTYVATYNDLPCTYHRAIGFVSRVRRALLSNPEQFFKLQDSLRKFKNSECSLSELQTIVTSLLAEHPSLAHEFHNFLPSSIFFGSKPPLGSFPLRGIQSSQFTLSNISDLLSQSRPDNLSPFSHLSNESSDFFKNVKNVLTDVETYHEFLKLLNLYVQGIIDRNILVSRGFGFLKSNSGLWRSFLSLTSLSPEEFLSVYNSACSDFPECGPSYRLLPVEERNISCSGRDDFAWGILNDDWVSHPTWASEESGFIVQRKTPYEEAMTKLEEERYEFDRHIEATSWTIKSLKKIQNRINELPEEERETYTLEEGLGLPSKSIYKKTIKLVYTSEHAEEMFKALERMPCLTLPLVISRLEEKNEEWKSVKRSLQPGWRSIEFKNYDKSLDSQCVYFKARDKKNVSSKFLLAEADILRSQAKLHFPLRSRSAFEFSFVYDNEIVLFDTCYMVCTYIVCNSPSGLKKVEHFFKNILPLHFGLEKDKFSIFLDQVFRGPDYDVNAPNIVGNKPVRRKRSNSITQLTEFVKQPKINGQRESRSAAAARKKEESGNKSQSNSQNSLSDESGNVTPVSKKQLSQPAAAIKASLKYPSHPDSLLEHQDHAGDTENEMHDDVDKEQFGYSSMYVFFRLFNLLYERLYELQRLEDQVSIIQQRIIPNPVSQKQKIWRDRWNDLSDVPDEKTHYENTYVMILRLIYGIVDQSAFEDYLRFYYGNKAYKIYTIDKLVWSAAKQVHHIVSDGKYKFVTSLVEQNSSASPKKNYDDFLYRLEIEKLLNPDEILFRFCWINKFKSFGIKIMKRANLIVDQSLDTQRRVWKKYVQNYRIQKLTEEISYKNYRCPFLCRNIEKERTVEQLVSRLQTKLLRSAELVSGLQAKLCLDSFKLLYLPRTEDSYIDASYLRLRDTDFLDCQNKRKQRWRNRWESLLKSVRGTSDNTAEVNFDADINALFIP
The following text describes a protein:
Function:
Probable chaperone. Has ATPase activity. Not stimulated by DnaJ.
Sequence:
MDNAELAIGIDLGTTNSLIAVWKDGAAQLIPNKFGEYLTPSIISMDENNHILVGKPAVSRRTSHPDKTAALFKRAMGSNTNWRLGSDTFNAPELSSLVLRSLKEDAEEFLQRPIKDVVISVPAYFSDEQRKHTRLAAELAGLNAVRLINEPTAAAMAYGLHTQQNTRSLVFDLGGGTFDVTVLEYATPVIEVHASAGDNFLGGEDFTHMLVDEVLKRADVARTTLNESELAALYACVEAAKCSNQSPLHIRWQYQEETRECEFYENELEDLWLPLLNRLRVPIEQALRDARLKPSQIDSLVLVGGASQMPLVQRIAVRLFGKLPYQSYDPSTIVALGAAIQAACRLRSEDIEEVILTDICPYSLGVEVNRQGVSGIFSPIIERNTTVPVSRVETYSTMHPEQDSITVNVYQGENHKVKNNILVESFDVPLKKTGAYQSIDIRFSYDINGLLEVDVLLEDGSVKSRVINHSPVTLSAQQIEESRTRLSALKIYPRDMLINRTFKAKLEELWARALGDEREEIGRVITDFDAALQSNDMARVDEVRRRASDYLAIEIP
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSLITDFPFHAYLGDLKTRRVMGAKDAVSLSLLASEDMSGIAFVEVRTRAGQEDRSAPWRPVVRNGENHATFYDTRMGNFDANPFPPQTCQTCAASLTGKYGNERCHGHFGFVGMPRIRPGSAHSDSDRLVVLNPHLAMDADRLFRAKCFFCHKFRAPTFDVERFRQALVLADHGLPGDALHLLDTVPTAKGHDAMLNHRRMANEEIVNDVSILQSYVDRILRQRASGCSEEDAKARVTMAQKGTVDVRNDICNMAISHLRSFSGPCSHCTAISPTFLKRGGIIFFLFRKSNLVTNIAKGFLTQQEVSEWEAVNRLHGRTGTYFDGRQMLFHMKNLFAKEQAILGLLYPNLGEPSVFTKTNKVVPASERYKLFFLDRILVPPLPLRLSSGVRVNDNGLIIPDEQTRALSDILGFVEQIECFHTLSANSTNGRSFITDAQRAVNESNLRNLQQKVDEFYAEIINSFAKKEGLFRMNMMGKRVNQACRSVISPDPFVEPNEVLLPRPLARALSFPEQVTCFAPARMNLLKHCVVNGPRKYPGATHIELRHANGEIRSVDLNVPEQTRRQHAARFFAMAQSGVTLIVYRHILNGDRVIFNRQPTLHKPSMMGYRVKVLSGSKTIRFHYVNGNSFNADFDGDEMNVHVPQSIETRAEVETLMDANINYLVPTSGRPIRGLIQDHVAAGVLVTLRDKFFDHSTFVQLVYNGVGPYIQENVGITLAELIPIPAILMPRPMWTGKQLISVMVRFSSGLSAASDCGREIEGGITLKGTSQIQPSAFDRIPAGSCDAVRVKSGAVVDSTVMFANSELITGFMCKKQLGASNMSAPHHVYELYGPHRTGQLFAAFGRVLLLALRKEGLSLAMDDMFLVDEERRCDLLRKLDDIALDVPDEEATAAPMIADYATKIQQEFVPQRMLVPFPKNHLLLMTISGAKGSNLNATQMSLQLGQQLFDGLRVKRMNSSKTLPSFFTNEKRARSFGFAMGSFASGIRPAEYTIHAMAGRDGLIDTAVKTSRSGHLQRCLIKGLESLVVHWDRTVRDSNGSVIQFMYGGDGLDPCKASTLTAWEMMKDNVVDVSKRFGGDASESVAGAEDGAAAGLEEMRNEDGKPTTEAVQNAHMEQQLSTYPLPASLDKSLSEYLCKKADFPLFRKVSTLARWDAKQQLKERLQQRRQKWVGAFEKTLADITARRRLWALCEPGEPVGLLAAQAAGEPSTQMTLNTFHTAGSTVSHVTEGIPRLRELLIYASVNKAAVVVPVTNATEEDEKVIAKMLRAGVAAKLTDCLAKVTDGAGGQSASSSMQRNLNTGFGKGYHYHVARGRTGMVITVSFLFSRSCLEELRKRMCMSPSEHRQSFTEALKNVVRLIMRSLSAVPREKESGDGSGNTGGMKGGSGRADRKRKRSGPDDGGGPLGGTFGDEIMRIEEGTDSDDGMSERSSIGGGRAGSEVSSLHSDGTDTRGIAGSDTGGPQRRRGSVESGRGDDASDSEAADPDLYARRSGSPARDAEDGDEMQDRDGTDWGGTSMQGVVGYDNFPEIHMSFTKSNFGAVIAPLSTAAAARDGVVQLHEDFFIVNAVLRTPSDVIAVIPDVVDNALEAQRMPSWLPQFGSLTFTRLKDKGSGQLVFQGPGSTMRNVMSFLSLFTVGIKSIKLHQACSTDIRDMGTYFGIESGYAALYDELNKLFNRYNVDPRHLSLIADTSTHRGRWENFNFTGVISTSASPLFQMTFASSKRWLHRAVSRGMSDDLESFSSAIMVGERPRVGTASVRLSTDTAILRDVLERNFA
The following text describes a protein:
Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Sequence:
MGNQGGARAHLRSSVNNYTFSPELLGRSPRSRLSLSMEDLDCTLSMNPRRRLRLSPEASDPHPEETTTPADTPQDSPSGSWGSPDSSSGSCSWSATALSFPKLQGPAGPPSSFRCPETSPDRRQEVRVVPEKSQQDELRSPGFAASSLALAPLPRVDDEILIEDVWRPFCLPVEAGKHQDLCYVSSDTVAALLRGGYAQSVEEFVVVDCRYPYEYAGGHIKGALNLYREDQLVERFLQGPRCPPEGPKSRVFIFHCEFSSERGPRLCRALRELDRRINQYPRLCYPELYLLRGGYRDFH
The following text describes a protein:
Function:
Probable DNA-binding transcriptional activator.
Subcellular Localization:
Nucleus.
Sequence:
MNICMRNGYEQFSLTSPGTSDLEIGGSFWKDEPDTKYLCLDSPVEQRQHQPPMAVCAGCRLEISDRYFLRVNPNLEFHAQCLKCVQCSRPLDENQTAFVKNGQTYCRDDYRRLFTTRCSRCHGDFDKTDLVMRAGPQNVFHLNCFACVACEKRLQTGEEFQIKNNSLYCRSDCRGLDNPDTSASVPDYSKLNNNNNNDNNNSSSNFDEDEWDEERSTLTSLDNNTSSPLGSPKSDGVRTPLFGHHNSGSGGSTSSCGKKKKDKQATRVRTVLNENQLKILRDCYSINSRPDATLKERLVEMTGLSARVIRVWFQNKRCKDKKRQIQITENRLNSEREEVLNRVRVNGIGPLMVQPATPHIDNTLGGPIDIQHFAQWNGTPPPPPPQYGNPMMFNSPSTFDVSVILAPVAPNVTSPSEALGPLGASVFPHFSPQHAPFTATSHDISSPAPCGE
The following text describes a protein:
Function:
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Sequence:
MMRLLICESPGKIKTFKAILGAGWDVQASLGHVMELANDGADHLGFDVGPEAITCRYVPRGERGMATLKKLRTAAAKAQEVYLATDPDREGEAIAWHLARELRLKSPRRIRCTQITEGAVRTALQSPGRLDMDLVSAQRARQCLDKLVGYKVSPLLWNATGGKSAGRVQSATLHFVCEREREIIAFVPVDYWSVWVEYAPGWRAYYQGDVQETPESTEATDDAKSNKEAPPAESTRVLSEAEADRLVALARSHPHAVERVERRTVTKIPPAPFTTSTLQQAAGALLSYNPERTMGIAQQLYEGIDLPTGRKGLITYMRTDSVEVAPEFVEQARTYLQINDPDNLPARSATHRSRAGAQQAHEAIRPTDVSLTPRTIRAHLSEEQLRLYDIVWRRAVASQCAPARLAKTKILTRSGPVHWQALGMTVAFAGYTRYWNDLEAALALPALEAGQNLELLRSAHEKKRTQPPPRYSEPKLVQLMERKGVGRPSTYASTIKTLKERAYVELQGRALVPTELGLATDALLGRTLPELVDSAFTARMETGLDAIAASREPWEKYLIGWNTDYLVPAVARARAAIAAEFPKRPAAPRTAQAPQISRTPCPRCRQALSKVPSKKVKRGYFLKCPACADLVMFWNPWRKIWELPKPKTDPQTP
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSANDILDVLNIQRDESNQPPKKKQKSSSTPTLPDGKQLTGMARELYNLVGPNTPPINLNSNSYTANKEKMKKFKPSPWTRMPFTPKQGIELNHWVKGSKELIEQQEFEEDGTPKPYFFEKYNVQLEIPEFVDEDTYDLYMIEIKEYESKMKEERARREKERKEREKRDLEEKKKKQQQQQQKSQQNPQNQIKDDEKNQDTRNNTDKKDSEQKSEDKPTVEAKKETDEKKDDVVLKDNTNETKPVTETTKSETETTEQNNSEKTNENETNKTNDKDGEGNLTKSKDSATEDQSNNKKENDEDTESEWTYKETKHLFELCQAFELKWPIIHDRFPNPNRTAEDLKEQFYRICIKILENQKNKNQALIDSLKAYCKPRELERKQYLENLLKRTPAEIAEEESLVIEARRFEIAAKKMLMERSNLLTLLDSPQTTQNVSQYQSSQGITNLYNNLLIYDKHQKKKQMANKSNPQQEPVPPPIPLAASSSVKRDRGFQTQLQQYLSSFLKQNHHTNPAVKQEINSIQQLLMKRLTQKEEEAYGLYFHGTEKLNPGVMLRSQQKLPGLNQRQSILKSVNILLQEMDIPTGGGTSWKPIMPTRKTMAKYDELIRSVVTLLDVKKAKDKLESEIKLIKSQRGL