lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3.
Sequence:
MAEENTQFCSNCKHNIPEANFTTHEIHCRRNIALCEVCQEPFPHAELVQHKEMDHAEEQCKCGLKIEKRFLETHQRSECSHRLVPCQFCDLELASFQAKEHEEYCGTRTEPCPVCKCNVMLREQHIHPALCGSLTPPEERHSSRAGPQSPGAWFETHSIHNLLRAQERSHNNNNTGAADRRGPPRPIEDRLHNSTRGTVRGGTRRNTETRNNEFAYLLDQETELGNNNNSLLWSLGQLPDYESSSLDYMLALSLQTEGDLEDPRQEGVWTDVWDQRMGRTPAHSNLTSQLSSNTSKNCTTAPPKTHTNLGQSPSSNIMLPCEFCEELFPEEDLILHQTGCSPASAIASFSKQVPSLQYEDIIPQGTSHVIPPRTPSPPTLPLSVSPISYSSSSSPVEGDVLIPCEFCGVALEENVLFHHQDKCDLRPHTAYFVDGVSSRKPHHTTKETHERRSPERQRRVRHQADPDEELLQQTAHGWQRGSSALDQWPSAHSYTKNTNAEQQVKSRNQRRRAVEVNTYLSDSPKPHSTTTSGTPHRGRLEGRRNEKNTETPKVPKKHNVEKEEE
The following text describes a protein:
Function:
Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. It catalyzes the cleavage of the alpha-1,2-glycosidic bond at the non-reducing end of 4-O-methyl-D-glucuronic acid (4-O-MeGlcA) side chain of short xylooligosaccharides and releases 4-O-methylglucuronic acid. It can also hydrolyze small soluble oligosaccharides such as dobiouronic acid, aldotriouronic acid, aldotetraouronic acid, and aldopentaouronic acid.
Subcellular Localization:
Cell outer membrane.
Sequence:
MSTFARLFLCLVFFASLQPAMAQTEDGYDMWLRYQPIADQTLLKTYQKQIRHLHVAGDSPTINAAAAELQRGLSGLLNKPIVARDEKLKDYSLVIGTPDNSPLIASLNLGERLQALGAEGYLLEQTRINKRHVVIVAANSDVGVLYGSFHLLRLIQTQHALEKLSLSSAPRLQHRVVNHWDNLNRVVERGYAGLSLWDWGSLPNYLAPRYTDYARINASLGINGTVINNVNADPRVLSDQFLQKIAALADAFRPYGIKMYLSINFNSPRAFGDVDTADPLDPRVQQWWKTRAQKIYSYIPDFGGFLVKADSEGQPGPQGYGRDHAEGANMLAAALKPFGGVVFWRAFVYHPDIEDRFRGAYDEFMPLDGKFADNVILQIKNGPIDFQPREPFSALFAGMSRTNMMMEFQITQEYFGFATHLAYQGPLFEESLKTETHARGEGSTIGNILEGKVFKTRHTGMAGVINPGTDRNWTGHPFVQSSWYAFGRMAWDHQISAATAADEWLRMTFSNQPAFIEPVKQMMLVSREAGVNYRSPLGLTHLYSQGDHYGPAPWTDDLPRADWTAVYYHRASKTGIGFNRTKTGSNALAQYPEPIAKAWGDLNSVPEDLILWFHHLSWDHRMQSGRNLWQELVHKYYQGVEQVRAMQRTWDQQEAYVDAARFAQVKALLQVQEREAVRWRNSCVLYFQSVAGRPIPANYEQPEHDLEYYKMLARTTYVPEPWHPASSSRVLK
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MKRFFNEACDINTPDKSGVNENKLCFPPLKVVCQAPETTVKGQVANTNKHNVYSTKNSMYLLGFEEILNTVLDCEPHIFTDDELRVIENFKALDSDERYLFVRLFMRKRNKWFRVGHLTYPDCKDVIACCKQLVLKNFFEDESLMSTEEIIEILSLDELRSLARQTKVCGKSRSEISKEIIFLSKRQSVLHCNGQQFLSFDAFGVMHKQESFLRKQLLYQCKSCVKPKKILVDLFHRINIVYFRSSIYDEQSLTSLILARLNKFSYPNYVLSRTSNVFNCRAQCLEYVEVLELSKNLVPIFENTAASDKEALEQALNSFFEIYPIWSTYLNEDIREFWVEENRKVDTRLVRFSFSFRPGAVYTYLIHKSLNILAKSRLVEVEHEILDTLLSQNIYLVGKRGHWYNRKALLEYNFKTEDTNVLRYWKTLALSTCENGIEDKYTHLRYYFSLQRRLVRLRKCLKVSNTTELKSMKLINNNPSRLFLHGERIHNGDLSNRTVWRSKTNNAITVEELALQHYQSIGWEGIHAESSILLTLFALTFWDILFEDVPGVFQSPFQSAPLDLHTDSFYISRESTIMKRLEEIRNGKAGLIIKDNYIREHQRKTFCVGLNWSYTCEMLLEIVDCINDNGLAQIFLALTQDYKNSSSGIPDLCLWNPSKKKFMFSEVKSDNDRLSEAQKFWISLLISSEVDVEVCHVSMHKKK
The following text describes a protein:
Function:
The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. This protein can degrade all purine nucleosides including xanthosine, inosine and guanosine, but cannot cleave adenosine, deoxyadenosine or hypoxanthine arabinoside. Has a preference for the neutral over the monoanionic form of xanthosine.
Sequence:
MSQVQFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNMAEGLSDVKLSHAQTLAAAELSKQNFINLICGFLRKIA
The following text describes a protein:
Function:
Extracellular matrix protein that plays significant roles in the vascular system and is required for the maintenance and stability of blood vessel. Affects several essential steps in angiogenesis including endothelial cell proliferation, migration, and tube formation. Positively regulates angiogenesis by acting as a ligand for CD93 receptor.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MGYSQGAGALATARSLERKDVAGNVKGARGLGWGGGCALAPSCSLGRVETWVWLSSPLLWLVLSRNWCPYQTSRLVTFVAACKTEKFLVHSQKPCPQGAPDCQKVKVMYRMAHKPVYQVKQKVLASMAWKCCPGFAGPDCQDQDPMVIPEPEDPGDSLQEPWDGPVSFEPGHLAAEFSNVVEQQEHRLGDLQNDIDQVADSLPGLWKALASNLTVATEANQTELEFPDRSLEQVLLPHIDTFLQGRFSPMWRSFNQSLNSLSQAIRNLSLDVEANRQAIKRVQEGAVARGDLQELGAKFETKVQENAQRVGQLRQDVDDRLNAQHLSLHQSLSEVQADVDSKLKKALKAQESLGANGSLVLAAAGAAARPEPESLQARLGQLQRNLSALHVTTAHREEELQSTLADMRATLARHVDEIKELYSESDDTFDQISKVERLVEELQVNHTALRELRVILMEKSLIMEENKEDMERQLLELNLTLQHLQGAHADLIKYVKDCNCQKLYFDLDVIREGQRDTTRALEETQVSLDERRQQDGSSLQALSGRVAVLAQAVEAHQVEAEQARADASRLRSKLRALGDEVSTLRATKGEFRREIRQLHSSFSALLEDALRHEAVLTALFGEEVMEEMSEEEPGPLPLSYEQIRVALQDAASGLQEQSLGWDALAQASRGGKQAERLEPSRDATPEEAGGQDSAGLAQALQRLSSDLERVGQCCEVSRASSFNSSLEDLRGALSTTEHGLEQHQRLFHSLFGNFEGLVAANVSLDLGKLQAMLSREGPKRRDRKQVEPLADTQVKGPALWWAGSPVAFYASFSEGTAALQTVKFNTTYFNIGSSYFPEHGYFRAPERGVYFFAVSIEFGPGPGTGQLVFGGHHRTPVYTTEEQRGRSTATTFAMAELQKGERVWFELTQGSIIKRSPPGSAFGGFLIFKT
The following text describes a protein:
Function:
Acts as a calcium sensor. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner. May function as a positive regulator of salt or drought responses.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Targeted to the cell membrane when interacting with CIPK24.
Domain:
The N-terminal 12 amino acids are sufficient for cell membrane targeting of a heterologous protein.
Sequence:
MGCVCSKQLEGRRQEDISLLASQTFFSEAEVEVLHGLFIKLTSCLSNDNLLTKEKFQFILIKNTKKRSLSAERIFGLFDMRNDGAIDFGEFVHTLNIFHPNSSPRDKAIFAFRLYDTRETGFIEPEEVKEMIIDVLEESELMLSESIIDSIVSKTFEEADWKKDGIIDLEEWENFVATYPLTLKNMTIPFLKDIPRIFPTFLR
The following text describes a protein:
Function:
Negative regulator, together with pgov, of the transcriptional activator nuc-1, which controls the expression of phosphorous acquisition enzymes.
Sequence:
MLTRSPASAAATSPTTTVTVTVTAAATSPRPSRGAAPHGHFHYAPTPSLREAASRIPALSSRRQSATAPATSSTSLPISIQSRHGPAPVASHTSSPVASDPGLGFPPSSRPQRWAGVDVVAQYSPMEPMDYTTGALLSSQAASSSNNQAVARGSIESRPSHIPNTVGPMASHEEQASALASTSEATAAPIPHGPTVAVAVPPTPGVYSAAPQPHPLSHTPQTGTPVKRRNSQGDVTHNQVEAASAGQSGPHSPKRARLAPKIVSRRYEHCPVEDLVVLIAHMLGELIELNDEAAQKVGQRHNLTRFHSRTTPGISVLDYLHRLAKHAYLSPPILLSMVYYIDRLCALYSDFTINTLTVHRFLITAATVAAKGLSDSFLTNTLYARVGGVRVAELNMLELEFLHRVDWKIVPDPDVLVAYYGGLVARCPGYILECPEPEEADDEDEDEELDESDAIGDDDDDIDGEGGEREEETSSSQRDRHAT
The following text describes a protein:
Function:
Probably plays a role in anchoring the complex to other cellular components.
Sequence:
MALVMHTYKGNKGANKALIAAEYAGVKIEESADFQMGVTNKSPEFLKMNPIGKVPVLETPEGPIFESNAIARYVSRKNGDNSLNGSSLIEYAHIEQWIDFSSLEIDANMLKWFAPRMGYAPFSAPAEEAAISALKRGLEALNTHLASNTFLVGHSVTLADIVTICNLNLGFATVMTKKFTSAFPHVERYFWTMVNQPEFKKVLGDAKQTEAVPPVPTKKAPQPAKPKEEPKKAAPVAEAPKPAEEEEAPKPKAKNPLDLLPPSPMVLDDWKRLYSNTKSNFREVAIKGFWDMYDPEGYSLWFCDYKYNDENMVSFVTLNKVGGFLQRMDLARKYSFGKMLICGSEGPFKVKGLWLFRGPEIPKFIMDEVYDMELYEWTKVDISDEAQKERVSQMIEDAEPFEGEALLDAKCFK
The following text describes a protein:
Function:
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSAEVSTNESAPPAEKKSKLTNAQKARIERNQAKAQKLREAKLVSHPFKELASNKEGGTHPEAALSQGSSVIKVQGTKYIDSGGGFLLEQPVMPTGVGPAGLNKSGEEAPPILDDAIAIPVQYEECLECGDMFADSYLFNNFGHSVCDKCRDKDERYALITRTEAKAEYLLKDCDFDKREPKLRYISRKNPHNVRWGEMKLYLHLQIHQRALEVWGSEEELVRQHEAREDKREEGKARKYNKKMKQLRMEVRSSIYTKKTHEVHEHEFGPDTYDEEEDTYTHTCITCPYSETYEKM
The following text describes a protein:
Function:
Involved in 20S proteasome assembly, facilitating the alpha-ring formation. Involved in maintenance of telomere length.
Miscellaneous:
MISCELLANEOUS: Present with 2210 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MLVKTISRTIESESGFLQPTLDVIATLPADDRSKKIPISLVVGFKQEASLNSSSSLSCYYYAIPLMRDRHINLKSGGSNVVGIPLLDTKDDRIRDMARHMATIISERFNRPCYVTWSSLPSEDPSMLVANHLYILKKCLDLLKTELGE
The following text describes a protein:
Function:
Binds to all microtubule populations.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTTTIIFSGKEGKNSSKVLAPPGGKSNNIFGFAEETPAPAQAQRRAPSQSPFAQDAAPKPQDSGPAKPFRPNTTYNPLTHSHAQRDQPPQQQAPQQQRAPPQQQQQQMAAPQQQTPPPQQQPLRASTLPQEPIGNNTDAKTSVKIYNPPGGKSSIQF
The following text describes a protein:
Function:
Involved in the migration of sex myoblasts (progenitors of egg-laying muscles), Q neuroblasts and BDU interneurons during development. Involved in axon branching and guidance of neurons including GABAergic type D motor neurons. Promotes sex myoblast migration and positioning independently of gonad attraction cues. May act downstream of mig-13 in order to promote the guidance, migration and positioning of Q neuroblasts and their descendants along the anteroposterior body axis. Required for coordinated movements.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MICASKITMLGLLVMCTLGGVLGKVDIRQTTANKAFMETMRADGYEVVHPFQIRDKNERIGIDTRNYFLKAQEHYSHVTIVIRSNQLGRLKLVLERNNFIFLNQTAFHKLDADGERVIQNRVENCYYQGTVGGEESSFVALSSCNGLRGVISFANGTTFGIWPLDGGDRNSRRHPHILYKSEWSQEAKCGSSMAHAVGQRRMKKHVHKHRSHHHEHNKKRDVSKRTKYVEVALIADYEFMKARGLHDLDAISYMLESLNIADSMLSRDLNIRLSAVYVELWTDVQRIDLWEDIERTLSGVVDYASGHIYHIQKDASILFTAGSFANQEVSNAAIRSICTARSAVIVKGVEQFATHWNGELLAQSIGHLLGLEHDTTACSCEPSPECVMRQQPGRVGGGGGSPFSWQFSKCSVARMHGIWQDGNIQCLLNKPFQVSELRECGNGVVDGSEECDCGSRENCQDPCCDPLTCTLRPHAQCAAHHKCCHRCELRKAGDTCRSSKSPCDVAEQCDGKSGDCPPDGHLIDGTVCGTDGQCWRGNCSDSHQQCQKLWGREARVAEPVCFEQNTKGAEYANCGQRQADGTYHPCQIEDTRCGTLHCHSGSITPIDSSLKAFTFHFTENSHQIQCKSIASAAVGLTSDGTNCASGRVCVAGSCVEMSSVSSATACPTNNLALLCSGHGHCTTTARCVCFNGWSGVACDIRSNSSTYQGSMGFGEEGSGGSSQKSSERKTIMIPHLNIGTTLETATLFAILLGFGVFLLLCLVCLMLCYRRRSVVEIPKPSDEKDEESPDRQIKFGNMPSYREEKRKRKSNKKIYGALNRITEADERDSTSLRSRDSAGGSQQLVDRRNGAPVVVGGIRDPYAGEHIYAESSSNHLTRQFRGINSDGSYPLRSFGSWRSSAPISPASSSGQLTDVSTATTPLRLNKIGKFLKTLQSDDESPSPFSDHQSFTTGIGIGARLEQMQFGGGGDEELSAVEADHDVGSNTESSRGCEEPMDPGSWDSPTLVNGASSSSTSNNYNFRQSPSLFSDPFKLEMTNSMHN
The following text describes a protein:
Function:
Subunit of the nitrite reductase complex that mediates electron transfer from quinol to the catalytic subunit.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Sequence:
MNKSKFLVYSSLVVFAIALGLFVYLVNASKALSYLSSDPKACINCHVMNPQYATWQHSSHAERASCVECHLPTGNMVQKYISKARDGWNHSVAFTLGTYDHSMKISEDGARRVQENCISCHASLSSTLLENADRNHQFNDPKGASERLCWECHKSVPHGKVRSLTATPDNLGVREVK
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MSLNVPSRRLLKSAPSSANALVPALQSLSINTRSIHTTPSQQWSLFGWGKQKVEERNKVKEELKQSELARTRKPTQEEIFERVRGRLEGDSIFADTTPSSQLAAEQDKHKDWATASAEKKLAAAHAKDQTPTGISLKKDHLVRVVDPDPRSRVRWERKMVIRKLQRGTDPWSVEPKAERIARTERKLVYKTGYLPTSVKKLVHLSRQIRGKTVSEALVQMQFSKKKMAKEVKTELLRAEAKAIVTRGMGLGKAAAAAAQKETGAEPVKIQTKDGKHLEIRDPTRIYVAETFVNKGFTRGVELDYRARGRVFKMNKPTTTMTVVLKEEKTRIREHQERVAKKLRQGPWVHLPDRPVTSQRQFYSW
The following text describes a protein:
Function:
Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (By similarity). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins. Also involved in the regulation of ubiquitin-dependent degradation of methylated DNMT1 and E2F1 (By similarity). Required for normal maturation of myeloid progenitor cells.
Subcellular Localization:
Nucleus.
Sequence:
MTESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALEVITDESEMESVKKATATTTWMVPTAQDAPTSPPSSRPVFPPAYWTSPPGCPTVFSEKTGVPFRLKEQSKADGLQFCENCCQYGNGDECLSGGKYCSQNCARHAKDKDQKDERDGGEDNDEEDPKCSRKKKPKLSLKADSKDDGEERDDEMENKQDGRILRGSQRARRKRRGDSAVLKQGLPPKGKKTWCWASYLEEEKAVAVPTKLFKEHQSFPYNKNGFKVGMKLEGVDPDHQAMYCVLTVAEVCGYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLRPPKGYKEEEFNWQSYLKTCKAQAAPKSLFENQNITVIPSGFRVGMKLEAADKKSPSVICVATVTDMVDNRFLVHFDNWDESYDYWCESNSPHIHPVGWCKEHRRTLITPPGYSHVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMKLEAVDKRNPLFIRVATVADTDDHRIKVHFDGWSSCYDYWIDADSPDIHPVGWCSKTGHPLQAPLSPAELMEPSETGGCPTLGCRGVGHFKKSRYLGTQSGANCPYSEINLSKERIFPDRLSGDTSPPTTPSFPRSKRMDTRESSSSPETREKHANNFKEDSEKKKENEVKTSAEAKVVREEPTPSVQQSQPPQQVQQVQHAQPPQQAQKAPQAQQAQQAQQAQQAPQAPQTPQPQQAPQVQQAQQAPQAQQAQQPQQAQQPQQAPPVQQPQQVQQAQPTQQQAQTQQQAQRRSAVFLSFKPPIPCLPLRWEQQSKLLPTVAGIPASRVSKWSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAAEKNSHNEL
The following text describes a protein:
Function:
Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Stimulates transcription from several principal sigma factor HrdB (SigA)-dependent promoters but not from a SigR-dependent promoter. Stimulation occurs in the presence of the transcription initiation inhibitor rifampicin (Rif).
Sequence:
MSERALRGTRLVVTSYETDRGIDLAPRQAVEYACEKGHRFEMPFSVEAEIPPEWECKVCGAQALLVDGDGPEEKKAKPARTHWDMLMERRTREELEEVLEERLAVLRSGAMNIAVHPRDSRKSA
The following text describes a protein:
Function:
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Sequence:
MSCPYAGNGNDHDDSAVPLTTEVGKIYGEYLMLDKLLDAQCMLSEEDKRPVHDEHLFIITHQAYELWFKQIIFEFDSIRDMLDAEVIDETKTLEIVKRLNRVVLILKLLVDQVPILETMTPLDFMDFRKYLAPASGFQSLQFRLIENKLGVLTEQRVRYNQKYSDVFSDEEARNSIRNSEKDPSLLELVQRWLERTPGLEESGFNFWAKFQESVDRFLEAQVQSAMMEPVEKAKNYRLMDIEKRREVYRSIFDPAVHDALVRRGDRRFSHRALQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLITKWRYNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFLDLFNLSTFLIPREAIPPLDETIRRKLVHKSV
The following text describes a protein:
Function:
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity.
Subcellular Localization:
Nucleus.
Sequence:
FPTLFPTVFGRAVHAMARISEEFWFDPMEQGLSLRSVNSSRSAYACIFFSSIFFQHYSWRNTSETDLHKKHIPLRCKLVIKAVLPLFRSLNTLERNVEKCTIYTNFRDCHIVFQLFCRHGVVKTHHLTFQECEPLQAVFAKNLCPNVLKIQQFSDILIHFPNGQDEVTLAVTPVKVCFKTYTEDEMDFPSPMHTEIHLSPEEFEYFQVGVDSEVTFCLKELRGLLAFAEALNTPVSVHFDLPGRPVVFSLEDTLVEAIFVLATLADVENRLSCESLQLSQMSMPWSFNYWLILSYGCLVVQYQLNSLISLAVIVQHVLLRATSTVLTW
The following text describes a protein:
Function:
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAPRRRASPGIAVACCWPLTVVLGFCVSFNVDVKNSMTFSGPVEDMFGYTVQQYENEEGKWVLIGSPLVGQPQNRTGDVYKCPVGRSESLPCIKLDLPVNTSIPNVTEVKENMTFGSTLVTNPKGGFLACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSIAPVRECSSQLDIVIVLDGSNSIYPWKSVTDFLNDLLERMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAANKIVQRGGRQTMTALGIDTARKEAFTEARGARHGVKKVMVIVTDGESHDNHQLNQVIQDCEKQNIQRFSIAILGHYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVEALGERIFALEATVDQSAASFEMEMSQTGFSAHYSQDWVMLGAVGAYDWNGTVVMQKANQLIIPQNTTFNVESTKRNEPLASYLGYTVNSATVSGDVLYIAGQPRYNHTGQVIIYRMEDGDVKILQTLSGEQIGSYFGSVLTTIDIDKDSNTDILLVGAPMYMGTEKEEQGKVYVYTLNQTRFEYQMSLEPIKQTCCSSLKHNSCTKENKNEPCGARFGTAIAAVKDLNLDGFNDIVIGAPLEDDHGGAVYIYHGSGRTIRKEYAQRIPSGGDGETLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAALFWSRDVAVVKVTMNFEPNKVNIQKKNCRVEGKETVCINATVCFDVKLKSKEKTIYEADLQYRVTLDSLRQISRSFFSGTQERKIQRNITVRKSECTKHSFYMLDKHDFRDSVRITLDFNLTDPENGPVLDDSLPNSVHEYIPFAKDCGNKEKCISDLTLDVSTTEKGLLIVRSHNDKFNVSLTVKNKKDSAYNTRTIVNYSPNLIFSGIEAIQKDSCDSNHNITCKVGYPFLRTGEEVTFKILFQFNTSYLMENVIIHLSATSDSEEPPEALSDNEVNISMPVKYEVGLQFYSSASEYHISIAANETVPEVINSTEDIGNEINIFYLIRKSGQFPMPELKLSISFPNLTSDNYPVLYPSGWSSSENANCRPSSLQDPRGINSAQKMIISKSEDLKRGTILDCSTCKFATITCNLIPSDMSQVNVSLILWKPTFVKARFSSFNLTVRAELQSENASLVLSTGNQKRELAIQISKDGLPGRVPLWVILLSAFAGLLLLMLLILALWKIGFFKRPLKKKMEK
The following text describes a protein:
Function:
Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.
Sequence:
MTSPLFLGLDASTQSLKASLLSVNLDVVAECAIHFDSDLPQFGTKGGVHFGSDGQVHSPVMMLVGAMDLLFDKIKIAGWKVDDIRGVAAAGQQHASVYWSKTSPKILASLNSSLPLSSQLVEAFSRPIIPNWQDSSTTAECQALDAAVGGPAALAQLTGSRAYERFTGAQIMRFKRVDPVAYDQTDRIGLVSNSVTTLLCLDGEVKGIDESDACGMNLWTMNRKQRGWNQELLKAIAGDDGAAELSRKLGTVETDGGRVVGRIGKWFVDRYGFSSECCVFPGTGDNPATFLSLTLRESEGLVSLGTSDVVLISTSAYHPDPDYHAFFHPAQIAPPSEQDDQNRQGAEPLRYFNMIVYKNGSLTRQHVRDLYFDGSWDKFNAAIEELRPKSVIDLPSRTAFWWLLPDIVPHGAHGIYKYITEPTAGTLFEVPAAKKVDQFPDIRQEALALLESQLFNYRSRASVILDDSSTPYDPSSPNVDAFLPRLTKVYATGGASANRTILSLMADVLSTKVCKNVEYLDGKWKDADWNACSVGVAYKARWGWERVIAADGDERKWVGFDTVIRECREARKKIRGDEGRGLELEEEGIRIVASPGPGSRAYERRIEWWRELERKALAEQRAEKTA
The following text describes a protein:
Function:
May be an activator protein for the gylABX operon.
Sequence:
MQRAMRLLERVAEHEYGAPAKQLARETGLALPTAYHLLRTLVHEGYLRREKGLFFLGEAAERLSGSGAEQKRRSTVVDTMARWRDAIGVPVYYATYRDGEIEVMCVSDTPGTPAVEEWADFRETGHAHAIGQCLLSQLDDDARRDHLDRYPVQPLTPYTVRDGHSLLKRLERMRRMAPVTERQEYALGTVCAAIPITVGTTAATMAISLPLHQADRLLPAAQRLQNEVGRRLGSLALSISI
The following text describes a protein:
Function:
Transcription factor, part of the diffuse TOX2 gene cluster that mediates the biosynthesis of the HC-toxin, cyclic tetrapeptide of structure cyclo(D-Pro-L-Ala-D-Ala-L-Aeo), where Aeo stands for 2-amino-9,10-epoxi-8-oxodecanoic acid. HC-toxin is a determinant of specificity and virulence in the interaction between the producing fungus and its host, maize. TOXE is a pathway-specific transcription factor which coordinates the expression of genes involved in HC-toxin biosynthesis. Binds to the tox-box, a 10-bp motif with the consensus 5'-ATCTCNCGNA-3', which is found in the promoter of all genes involved in HC-toxin biosynthesis. Required for pathogenicity of the fungus on maize.
Miscellaneous:
MISCELLANEOUS: The genes involved in HC-toxin biosynthesis, called collectively TOX2, are organized into a diffuse cluster that spans >500 kb. All of the known genes are duplicated or triplicated within this region, with some variation in copy number and chromosomal location among different race 1 strains.
Subcellular Localization:
Nucleus.
Domain:
Contains a basic DNA-binding region at the N-terminus which is usually found in bZIP transcription factors, but does not contain the characteristic leucine zipper domain. Instead, four C-terminal ankyrin repeats were identified that were shown to confer protein-protein interaction of regulatory proteins.
Sequence:
MGTTSPNSEKRQITDINERRKLQNRVAQRKYRTRQKTRMKLAEAVLNDYTYIHPTLGTIQSKKKSPLTMECDRSSASYPDLSSYAEICSETRSETQATRARQLTSQRTCFRESVDNNQADSHAQLSRCLNRQEMFYGISGETEFSEGDTRDRVECIDPNLTRGWLDMDLRSGTPNSSTVVDCGLCTVGANSQPPTRTNVQEAIETLELFEPNDQRKTENLPREPCGSCPSSSHGYSPTSGNPSTLLLTPSESLMNSVIVTSDSPLLAADDKSPGDLVISEANTHGPKEDQFSPLMTAISLGRLDIARILLQSGAPLDIPDDSGKTALHRAVGRRELHMVEALLNLGAEMLATDHEGNSLLHIAVKTNSLSITRLLLERYKSCRELKDAQLGHGCRQHGNQVHSESWIDLRNREGMTAVHLSVIFNRPEILQLLVKYSANVN
The following text describes a protein:
Function:
Involved in regulating left/right asymmetric differentiation of the gustatory ASE neurons. Plays a role in modulating expression of LIM/homeobox protein lim-6.
Sequence:
MTSIHSPVTRKEDTELKRPDLRGKFVCSSCSQNFQHSASLNRHRQLMHSNEHTCMMCERALNQKETIREHMRNEHNLAQVFTCGCCNWTFASKRQLTEHTKCIQGTGAPGDTIPIAKSINAPGSLIQSTIQGTPPVVKTGRKRPMGGSLSPSSSVSTSISSRDASGSPPPTEEEAERKVLFDNAVDTILQSKFFTYQQITEVDTWVKIIESANTLADTLQRIKKSQKVKAEGPAVESKMIPEKHVKQEIE
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MEEQKMSLIEHLSELRKRILVCLIALIIAFIFTFSYSEYIFKLLLFPLNYTPQFSLKEGMVFVPDQKLQNTKLVFLGPAEAFWMNMKIALVTGFILTIPIIFYQLWRFVSPGLYAHEKKYVLPFVLTATGLFLTGVAFCYFIVLPFAMGFLLNYKVGDFLMPMLSVGLYIDFLLKFLLAFGLVFELPILIVITTRMGLITPQTLKKYRRLAIVLAFVVAAIITPTPDAFNQTLMAVPMIILYELGIWVSILLNKKGKNSGGQN
The following text describes a protein:
Function:
May be involved in spermatogenesis.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Mainly cytoplasmic.
Sequence:
MEQSEAGSAADSIITQFNTYEDFLDSQITALDLHYLEDEELARQLVELGYRGSGEVLKRDEFEARKAAAEASRLSQRTQQKTLSSAGKDPKDNFLKALAMREEANRNGKMTSVIFIRDKNAHGQEVSGYIDFAHRLKTEDFEVYFSGKKKLLPRPTDLSFYNWESHVSTSNPSPNYQVIAETSSGLLFKNKRDRKILNVDPKASPGDNSTRTSIQTDIYIQAVIYDHITRRKS
The following text describes a protein:
Function:
May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus. Cytoplasm. Membrane. Note=May be also cytoplasmic and membrane-associated.
Sequence:
MAASLGGMFAGQPPGPPPPPPGLPGQASLLQAAPGAPRPSNSTLVDELESSFEACFASLVSQDYVNGTDQEEIRTGVDQCIQKFLDIARQTECFFLQKRLQLSVQKPDQVIKEDVSELRSELQRKDALVQKHLTKLRHWQQVLEDINVQHKKPADMPQGSLAYLEQASANIPAPLKQT