lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways. Restricts the replication of multiple viruses including flaviviruses or coronaviruses. Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities (By similarity). Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity (By similarity). Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP while CMP and UMP are poor substrates. Controls therefore mitochondrial DNA synthesis by supplying required deoxyribonucleotides. CMPK2-dependent mitochondrial DNA synthesis is necessary for the production of oxidized mitochondrial DNA fragments after exposure to NLRP3 activators. In turn, cytosolic oxidized mtDNA associates with the NLRP3 inflammasome complex and is required for its activation.
Subcellular Localization:
Mitochondrion.
Sequence:
MALISRPRAPLWLGRLSRRLCGRHQACMGTMARPRRFTVELPDCSLTHFVLGDATDHRDARLAELLGPPGRSYALCVPLAPGEGCGPRVQAARVHHRLLQQLRRGPLQRCQLSKLLGYGPGDQAGEAQHGFLLRDPCDHPDTRRDLLQLLGSCQEAARPQLAEFQADSQGLLWQRLWELQGDRQVQVDCACVLPAQEPHLHPLLPDLLNSAVFQDRDAARAVLEECTSFIPEARAVLDLVDQCPKEVQKGKFQVIAIEGLDATGKTTLTQSVSESLKAVLLQSPPPCISQWRKIFDDEPTIIRRAFYSLGNYLVASEIAKESTNFPVIVDRYWHSTATYAIATEVSGGLQYLPPAHHPVYQWPGDLLKPDLVLLLTVNSEERVRRLQGRGQEKTKEEAELEANNVFRQKVEMTYQRMENPSCHLVDASPSRETVLQKVLELIQSSGR
The following text describes a protein:
Function:
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
Sequence:
MENRIEMSQLRASKKDSKISYVLLMATKLYLEGGQPVGSKLLKETYCSDLSSATIRNYFAQLETDGFLRKNHISGGRIPTDLAFRYYADHNAPFLEQEEILAIQQKLTELPEYSKNIVKDLQKASEVLSDILQLPVCFSSPRFESDSVINIQLVAIDDQRVVFVLSTEFGQVFTDVLWLPEQLPENSLKRIEGFLQNYLRKQPSDSLLSQKEKDLGMVLYNEVVVRYLTRYCHFSEEDLYQTGLSRLLKYETFKDPETLAQGLAFFENRKHMCQLLNTYLHKETPTAFIGRELTDIVGNTDPSCAVITIPYYMDRTPLGAFGVLGPMNLPYQQVFGTLSLFTERLKVILTQSFYKFKLSFRRPCPTDPRCSQRPAELTRSSSIKLLPAKELS
The following text describes a protein:
Function:
Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.
Miscellaneous:
MISCELLANEOUS: Present with 3290 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence:
MSTNTSKTLELFSKKTVQEHNTANDCWVTYQNRKIYDVTRFLSEHPGGDESILDYAGKDITEIMKDSDVHEHSDSAYEILEDEYLIGYLATDEEAARLLTNKNHKVEVQLSADGTEFDSTTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDFKKDFYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVALKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFLLHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFGYVCYDECHFFLHHSKLPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDEVFGTYLGPDAPLSKMKYE
The following text describes a protein:
Function:
Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (By similarity). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWRLRLLVLAVLAAGSAEAQANSSDGFLEFSVGKFTYFVLSKSSPQEAVLRHISSNVTFLLFQIHSQYQNTTVSFTKTLLPSTSGTGNDRGLVFILRPEQAVCTWYLETGDTKPVQSVALTLSYSERDPIPGGCNLEFDLDIDPNLYLDYNFFETTIKFAPANIGYARATEPPPCDVSTSRESRWRLRYDVYQYFLPEGDLTEASLLHHLQRMAQVAQVKASAIKVATLTADDKTAVSFSSLPGQGVIYNVIVWDPSLNTSAAYVPVHTYACSFESVDGNCASPGRVSTKVFSTLFALLGLFVCFFGHRFWKTDLFFVGFIFLGFFFYILITRLTPLQYDVRLALTAVAGSFGGLLLVASWWRFGILTLCMLCVGLVLGFLVSSGTFFTPLGNLNVFHDDGVFWVTFSCIALLVPVIFMGCLRILNILACGVVGSYSVVLAVNSYMFTSLSYITLNVLRRALNTDFRGAFIRVPFQTNDYIILAVWGMLAVSGITLQIRRERGQPPFPPHPYKLWKQERERRVTNILDPSHHIPPLRERLYGRVARIKELFQKEQPAGERTPLLL
The following text describes a protein:
Function:
Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume (By similarity).
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein.
Domain:
The RFXV motifs mediate binding with OXSR1/OSR1 and STK39/SPAK.
Sequence:
MEPGPARPRLAPAARPGWGRAAGCRRRGGPARHGRASGQEDATTAGRQAGGGVRGEGTPAAGDGLGRPLGPTPSQSRFQVDPVSENAGRAAAAAAAAAAAAAAAGAAGKETPAAGKAGGESGVAKGSEEAKGRFRVNFVDPAASSSADDSLSDAAGVGGDGPNVSFQNGGDTVLSEGSSLHSGGGSGHHQQYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVAYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVVVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIADFVIGTFISLESKKPKGFFGYKSEIFNENFGPDFREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTVVYIGIAVSVGSCVVRDATGNVNDTITTELTNCTSAACKLNFDFSYCESNTCSYGLMNNFQVMSMVSGFAPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLIGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLSALQHSIRLSGVEDHVKNFRPQCLVMTGSPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQARYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQFGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVNVDYSKKSDQDTCKSSGEKSITQKDEEEDGKTPTQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIIAFDDMIEPYRLHEDDKEQDIADKMKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPVLLVRGNHQSVLTFYS
The following text describes a protein:
Function:
RNA-binding protein that acts as a post-transcriptional regulator of phosphate metabolism by binding to the 3'-UTR region of PHO4 mRNA, decreasing its stability. Acts by recognizing and binding N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs.
Sequence:
MNQIWSTGPPNFYFNSEWKENKRNDRTIEDSLRELDGLIHSLERTHIEVQTNPKLKNDVTALNDINKKENKEEITHENYTHQINSIPLTSSNLNRHFSFSRDYNQSDNSNNNYYREYLSKPRYLQQSTKEQTFNEINKRKSAAIIPPWLNIPENSRFFVIKSSSLKHVKRSFYNGIWSSTHFGNKRLSEAYKKLNSGAKVFLFFSINTSGRFCGVAEMVSDLKMDLDTSIWEDEQKYGKAFKVRWVIVRDINNRSLKRFLIPSNEMKPITHSRDTQEIPYSIGISIINLFKTQDSDIFSFLDETYE
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MKLVNLKQAILQAWKERWSDYQWAINMKKFFPKGVTWDILNLAEALLDQAMIGPAPNPLILSYLKYAINSQMVSYSTVLTAISKFDDFSRDLCIQSLLEIMDMFCDNLSCHGKAEECIGLCRALMSALNWLLRCATFYTDKLKDVLDPVAGENHLSMCLQRLKSILGSTKNRALIHIAKLEEPTSWTSVEQSQLRLSESISLLPSVQLRNQAEECVSLIRSIPSMLSVHSDQLQTNGFPTVHAVVMLEGTMNLTGDAQPLVEQMNTVKRMQRIPLHLFLLEVWKACIVGLIESPEGTEELKWTAFTFLKIPQALAKLKKLSSMEQDFNEDMKCAFEYLLKLTPLLDKADQRCNCDCVSLLLQECNKLGLLSEQNMENLMAKRTADREQAPRLKSSENSTIQPNPGLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFIQLNEFTRHIGVESSKAANVRALLFDISFLMLCHVAQTYGSEMILSEGCPGGEMPFFESWMQTCMPGEGRVLNPDHPCFRHPDIAKVEALVALLNTSTEMKLAQTKWHEVCLSIPAAILEIHNAWENGVLSSEAIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDERDKSLQMIRQLGSPMFGDNTLQFYSERVIIMSSILDNMCSEVLQQTTTQIKFSAAGSEPMPYIHRLPPKTPIKEVLRGAFSSTLEKGWVDSRTLHNFDTLLHMGGVYWFCNNLVKELLRETRLEFALRAVELLYAIFCLDMQQLTLTLLGHVLPSLLTDSAKWHMLMDPPGRALAKLSVWCAMTSYSTQNKGQPSPRQRKRHREDIEDYSSLFPLDDTQQSKLMRLLSSNEEEHNVQANPVDRPMNSSLSASQIHNISSKEPLNRVLANLFLLISSVLGAKTAGAQTQFVQWFMEECVESLELGGKGCILQFMPFSMVSELVKVSTLSSPKIVLAITDLTLPLGRRVAAKALTAL
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
SLINLEATAAEEAIKLSGAEAKLNGPLPAGLPTKVPPITTVTCEVHNKSKTKCLEAQCKWGGKKDDDGPCQASDKQVSEQTKQGGRDTTTGGDVKKEDKCTGKDEKTCGGTQGCKWEGTECKDFSLLVNNKISIIVSVSVSLVAF
The following text describes a protein:
Function:
Probable serine hydrolase.
Sequence:
MNTNNNFSNGEEVSIHIGTGIDIAAKAWGPKESSQKMLALHGWLDNANTFDFIAPILAEKGIRIIAIDFIGHGLSPHKPSWCNLYYTDYITQVLDVAEALQWKTFSIMGHSMGAGIASIVAASMPHLVERIICLDFIGILSKEQDQIKAIQFAMQTRTTINNRKPHLYNNKQAIFDKLKANNPWIKDEAGQRLLDRSIESVISPTTGEQCYKLRHDPRLVGPSIFIMREAEVLLMLDEIQCPVLLIWGTTSSQQFQIKKNWTQIMEGRMSHIKNLKQLVVPGSHHFHMENTSAFSQDILEFMFEEKDLSFTPSSTTQQQQQQQQSAENKKGDNHNQIAEQDLSTSNTSSPIISKPKPNL
The following text describes a protein:
Function:
Has aromatic amino acid transaminase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MIRNSEDFSHHLSRESKAREKGPFQMLGRIKSSTGIDAISFSSGLPHPNKFAIRELSIKFPQLGCFKEENGTYAKEVNVTFNIKADPSEGLLNFSQSLQYGQCQGISELVGFIKEHIRRIHAPRYENWDIKMSNGNTSGLEYCLRLLVNYGDHVLTEKYTYPAAITAMRALGVQFVSVDMDSEGMLPESLEEIMRDWDISLGPRPHVLYTVPTGQNPTGSTLSLSRRKKLLALARKYDIIIVEDEPYYFLQMEDYNGSLNPAQQKCDGSTFLKSLVPSLLSLDTEGRVLRLDSFSKLIAPGTRLGYITGNSMFIDHITRIAEVCTESPSGICQSVLYAMLHNWGQEGFCAWLQELQYSYTVRRNAFLNVANKYLPNSVCIYHVPRAGLFLWVELNLNHYRFSDTKKSVSQIEMEIFLALVEKGVKTVCGQFFMANPERSTKIFFRFAYSIADFEDFEEGIKRFTSVINEHFNVESRVRICP
The following text describes a protein:
Function:
Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
Purified ATP synthase is 25.9 nm long. The hydrophilic A1 domain is 9.4 X 11.5 nm, the central stalk is 8.0 X 3.9 nm and the membrane-bound A0 domain is 6.4 X 10.6 nm; the domains are connected by two stalks. ATP is synthesized or hydrolyzed by the A1 domain while ion translocation occurs via the A0 domain.
Sequence:
MGVDKIKSKILDDAKAEANKIISEAEAEKAKILEKAKEEAEKRKAEILKKGEKEAEMTKSRIISEAKLEAKKKLLEAKEEIIEMAINKLKEELVKLPEQPEYKDKLIKLIKDGAISLGGGELIVRLNKRDMELIDDSTLWNLEKEVENATKKVTVLKKGEPVDIAGGCIIETADGLKSLDNSLEAIFNRNLNVIRARITEKLF
The following text describes a protein:
Function:
May serve as a scaffold protein required for the formation of a complex with MrcB/PonB and MltA, this complex could play a role in enlargement and septation of the murein sacculus.
Subcellular Localization:
Cell outer membrane.
Sequence:
MTKLKLLALGVLIATSAGVAHAEGKFSLGAGVGVVEHPYKDYDTDVYPVPVINYEGDNFWFRGLGGGYYLWNDATDKLSITAYWSPLYFKAKDSGDHQMRHLDDRKSTMMAGLSYAHFTQYGYLRTTLAGDTLDNSNGIVWDMAWLYRYTNGGLTVTPGIGVQWNSENQNEYYYGVSRKESARSGLRGYNPNDSWSPYLELSASYNFLGDWSVYGTARYTRLSDEVTDSPMVDKSWTGLISTGITYKF
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MPSRKKCGNPLFLQWMEEIRDAAREKGSKSAETYSKACRSLEFCPVTYDRPRDLAILAHIGEKTIAQLENRWIEYRKSHGLDVPAEPEKLSTAEPKTKDKGKGCAAPDVDGPMSGTSQETTKKTRKTTAKAYIPTQGSGAYAILLALILAIDRPEVTTQVFLTKSEIIRTAQEYCDTSFEHSEKGTYFTAWSGMKTLVNKGYVYVTGNPHKHCLTEEGYDVALAIRNLRPEFSHMKKHPFSHAPAPGTSNRVTELPRNRAITALDLYNGPSIVPSTLSTEYVPPANAHSSPASRLASFDAVASKLTAGERFNFWYITPSGSRTPLMTSAHLRLDPEQFVNLRRIEFKYSQRNHPFAAQLRLMDAPTTAKLRDKSGVPTLYAYLIEADAPPKCSMFDTESSQSRAKASGKDNASNAGSSPLGSSPAPISRSRSGLGGRNDSCASLSDGGSRLSASAGKPTDPFYFDVRTLALQKNPSMPSNSASTSQSVSRSTSSSRPLSNSGPSPYQNPYDAILGQNPSSPPVSTLSRTITAPASTSSQPRTSSLSTLNIGSSSTVPSISNRSYSSAAVLPSRPVVPRMGPRLSNHVPSPIPAPERFDDTIIPPPDLHSKSLPPFTISNAIVFPPGSYDIILIIDTREVESSKTKNRDKIAETLEAKGIRVETRALRLGDMCWVARRKDGLGGEEDECVLDYVVERKRLDDLVNSIKDGRYTEQCFRLSNACLSNVYYIVEDWQVSERMEQSGLAIMTVKSQVQVHNRFFLKETHTLNETIDFLATMTRVIISSHRTKALHVIPTHFLSRPSFKPLQDHLQLKHPNIKFHTSFIAYQELNDKSASQTLKEKFAKMMMCVKGMSAEKVSALLDEWETPRVMWEDMKERDRQPDDSEPPGQPRGKKRKGGKGSFFAERVQGEARRKIGDALSESLWTALMG
The following text describes a protein:
Function:
Involved in trafficking and recycling of synaptic vesicles.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Early endosome. Golgi apparatus, trans-Golgi network. Late endosome. Membrane; Multi-pass membrane protein. Recycling endosome.
Sequence:
MKNPYRLDPDDAEFSFGETNTTRPWKKVALAIGLLVVGTVLLSVGLGLYLSGKQEQGGLPLIILGSITFIPGSYHTRIAYLAWKGRNGYSLNQIPDF
The following text describes a protein:
Function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MKLLQDDETKLSHQTKPNKWETRANRCPFSIPVRNVKDGSSLKDMLHHQAVKNQPCTSKVCEGSVMTPKALLRGPKVSTLEILPQAIDLINQYYKSFKIPKIEHHLARLEEITMEIDSTGTYQLTVEELAFGARQAWRNAPRCIGRIQWSNLQLFDARKCKTTQEMFQFLCEHLQFATNGGNLRSAITVFPPRKEDGHDFRVWNSQLLKYAGYQMPDGSIQGDPSSVEFTKICIQLGWKPQYGLFDVLPLVLQVNGEDPDLYEIPPHLILEVSMEHPQHKWFQDLGLKWYALPAVSNMLMEIGGLEFPACPFNGWYMGTEIGVRDFCDYQRYNILEEVGRRMGLETHKLSSLWKDQALVTINVAVIYSFQKNKVTITDHHSAAESFMKHLETEFRLRGGCPADWAWLVPPMSGSLTPIFHQEMVNYILSPFFYYQPDPWMTHVWRNGEMCLKKQQISFKAVARAALFSSTLMSRVLAKRVRCTVLYATETGKSQTLAQRLNSMLNGAFNSRLLCMEDYNFSDMEQESLLVVVTSTFGNGDSPGNGESFKKQLFSLQYLRNKLRYCVFGLGSRMYPQFCAFAHAVDAKLEELGAERVTPTGEGDELNGQEEAFSAWALTALKDAYKEFKIQGQLSLQLPGAERFCEAWDPLRHRVAVESCPQDRITALSAIHSKTVFPMKLKSKHNLQSPHSSRSTILVELERERSAEVMNFAPGDHVGVFPGNLPQLVAGILKFLPHTPPTNQCLRLEYRSDTCRDDEKNWQTVGRIPACPLSQALTYFLDVTTPPSQNLLHKLSQLAKQEGHRQRLLTLAKDSQEYTTWKMFRVPNFLEVLEEFPSLELSAAFLLSQLPLLKPRLYSISSSPQLHPNELHLTLTVLNYHTQDGQGPLHHGVCSTWLDTIKKGDLVPCFIYSSGGFHLPAEPSTPVILVGAGSGIAPFRSFWQQRLHDMKHPEFSESPMSLVFGCQSSETDHLYKEETLEMRRRGVLKSVTNAYSRQPGLPKVYVQDVLRERMAEEVLSVLHQKEGHFYVCGGVNMAQGVTLAVQEILSSQLGITLTQAGEYLTQLKIQKRYHEDIFGAQFQK
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGKTGCLCCDCPTREISPISLRDEEEDERWQPLMDRSCTDVIALVIFILFWVGMFFIAAYSIAGGNAYRLAYGTDSYGNVCGMKNEKNANINLKSAGLDMTGRPYVFFMDLFNPADALEICVSKCPDQDLNSIQEVQEFAKNSSSSLCEYDVKQENILTAGQSHLGPCPSTPVKASTSFLNRCVPKDAPDFLVKFMAILNSYDIFYKVLSDVFQARAEIAGMCVLALVVALLMVALIRFVAGFVMWIFMGIVAVASIVGTALLWWTYATKNQEYYAVPENERLDENGKDVTAFLVYSIIATIATVVLLIVLIVMRKRVKLVVALFHEAGKVFMHTPLLVLQPLWTFIALALFFIYWTAVLVFLATAGEPTVDTSTGWVTYRDPEPVRYMWWYHVVGLIWTSEFFLACQQMVIAGAVTQVYFTRDKKQVSSPILKATGRLISYHLGSVAVGSFIIVLVKIPRLILTYIQAKLKDKENSCVQFTLKCCMCCLWCLENCLKYLNYNAYTVIAIEGTSFCTAARRAFLALVSNALRVVAINSVGDFVLFLGKLGVVAIVGAISLIIFRAPSEVERTDARLHYYAVPILVICVFAFFIAHCFLSVYEMVVDTLLLCFCEDCRINDGSPGREYYMDKSLLEFVENSSEALKNLDKKKKKETANANANEHVELKETMNSSSKADYV
The following text describes a protein:
Function:
Mitochondrial methyltransferase which methylates cytosine to 5-methylcytosine (m5C) in rRNAs and tRNAs at multiple sites. May play a role in the translation of leucine and proline codons.
Subcellular Localization:
Mitochondrion.
Sequence:
MSCLRQSSQSFYFTQIRWKTVKFKTKIAKTKPLKTPSAQALDHFDFYYGPLFGKKWPSIRLGLLSPNRYLAVMNTMSRNWQAHDEILSDMGAKDLLASIRGKAEDQAIETKRKSVEEKANRETQKVKHEISNPSTSTNTEDSEPDEAIFRSAAGLGEFRASAGELSSGSLQMGLGQSNQNKNVEITGFEGEGVRIPKRDHFFYYPQALHVRSFDRAVLLDFPAPMKDEVGVPSYWLLDGGSLLPVLALGLQKDDSLLDMCAAPGGKSLLAALSNLPSKIVCNDFKLARLGQLKRALMTYVPEDSETIDKFVLKRKDASDVKTWDEFEAYDKVLVDVPCSTDRLSVSTDDGNLFSTGSTQQRLDLPVLQTKILVNALRSVKVGGSVVYSTCTLSPSQNEAVVENAVAVVRNDFGIVTVEESLHQLVSHMTSSGLYRFHDTPLGALVVPFLPSNFGPMYICKLTRLQ
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. Directs ubiquitination of the phosphorylated CDK inhibitor SIC1. Involved in the degradation of CDC6 together with CDC34/UBC3 and CDC53, and in restricting the degradation of FAR1 to the nucleus. Is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. Required for HTA1-HTB1 locus transcription activation. Required for G1/S and G2/M transition.
Subcellular Localization:
Nucleus.
Sequence:
MGSFPLAEFPLRDIPVPYSYRVSGGIASSGSVTALVTAAGTHRNSSTAKTVETEDGEEDIDEYQRKRAAGSGESTPERSDFKRVKHDNHKTLHPVNLQNTGAASVDNDGLHNLTDISNDAEKLLMSVDDGSAAPSTLSVNMGVASHNVAAPTTVNAATITGSDVSNNVNSATINNPMEEGALPLSPTASSPGTTTPLAKTTKTINNNNNIADLIESKDSIISPEYLSDEIFSAINNNLPHAYFKNLLFRLVANMDRSELSDLGTLIKDNLKRDLITSLPFEISLKIFNYLQFEDIINSLGVSQNWNKIIRKSTSLWKKLLISENFVSPKGFNSLNLKLSQKYPKLSQQDRLRLSFLENIFILKNWYNPKFVPQRTTLRGHMTSVITCLQFEDNYVITGADDKMIRVYDSINKKFLLQLSGHDGGVWALKYAHGGILVSGSTDRTVRVWDIKKGCCTHVFKGHNSTVRCLDIVEYKNIKYIVTGSRDNTLHVWKLPKESSVPDHGEEHDYPLVFHTPEENPYFVGVLRGHMASVRTVSGHGNIVVSGSYDNTLIVWDVAQMKCLYILSGHTDRIYSTIYDHERKRCISASMDTTIRIWDLENIWNNGECSYATNSASPCAKILGAMYTLQGHTALVGLLRLSDKFLVSAAADGSIRGWDANDYSRKFSYHHTNLSAITTFYVSDNILVSGSENQFNIYNLRSGKLVHANILKDADQIWSVNFKGKTLVAAVEKDGQSFLEILDFSKASKINYVSNPVNSSSSSLESISTSLGLTRTTIIP
The following text describes a protein:
Function:
May play a role in supplying butyryl-CoA for straight-chain fatty acid biosynthesis. Catalyzes the conversion of crotonyl-CoA to butyryl-CoA. It shows a high substrate specificity for crotonyl-CoA, a short-chain-length (C4), but no measurable activity is observed with shorter (C3) or longer-chain-length enoyl-CoA thioesters.
Sequence:
MTVKDILDAIQSKDATSADFAALQLPESYRAITVHKDETEMFAGLETRDKDPRKSIHLDEVPVPELGPGEALVAVMASSVNYNSVWTSIFEPVSTFAFLERYGKLSPLTKRHDLPYHIIGSDLAGVVLRTGPGVNAWQPGDEVVAHCLSVELESPDGHDDTMLDPEQRIWGFETNFGGLAEIALVKTNQLMPKPKHLTWEEAAAPGLVNSTAYRQLVSRNGAAMKQGDNVLIWGASGGLGSYATQFALAGGANPICVVSSPQKAEICRSMGAEAIIDRNAEGYKFWKDEHTQDPKEWKRFGKRIRELTGGEDIDIVFEHPGRETFGASVYVTRKGGTITTCASTSGYMHEYDNRYLWMSLKRIIGSHFANYREAYEANRLIAKGKIHPTLSKTYSLEETGQAAYDVHRNLHQGKVGVLCLAPEEGLGVRDAEMRAQHIDAINRFRNV
The following text describes a protein:
Function:
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Sequence:
MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASLQEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFHLLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAEKLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDGGDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGKDRTICALIHKNK
The following text describes a protein:
Function:
Involved in the caffeine degradation, which is the essential first step for assimilating the carbon and nitrogen in caffeine. Probably catalyzes the N7-demethylation of 7-methylxanthine to produce xanthine and formaldehyde.
Sequence:
MHAENSFVIDDWYPVGALAETVSGRKYHTRILGTEIWYQLADGTVSAGLADNTAELASKSIYGLLWVSLSDNPRDVIAIPEFAEADRRVVSAGSIRVATSGLRVIENFLDMAHFPFVHTDILGAEPLTEVAAYDVEIDEAADEIRAVNCRFPQPKGSAAASEPVEMQYVYRIARPFIAILYKTCVIDANRLDVLGLFVQPVDQESSIAHTIMCYLDDINTDKQLRDFQQRIFGQDIMILINQVPKALPLNPRHETPVRADALSSAYRRWLNDRNVTFGTTRG
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MAIIMAESSYERRIKALYEKQIRMEALEGKFIKKVFKFNSVLLDIKETSARHQRKVGKMQKVVTERREELGRRVTFMGHLTQEVEAIKLRNLAMKDQIKQQKMLNNQRKNEIMERIHTLSKTTGTYVNQEALPARVKGVTVIPGDRRNQLIPFDLNATDDEGLNSLCQHLESLNVDVSQWQQLVSLAMDVALGARAPTTPPKEAANCKSIIEIDLTSPTS
The following text describes a protein:
Function:
Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MTEAIHSQYDSILILDFGSQYSHLITRRCRELNVYCEMLPCTQKIKDLDWKPKGIILSGSPYSVYDEVAPRVDPDVFTAGVPVLGICYGLQEIAWNHGGKVDPHDKREYGHAMVEVVKHGVPHLDALFKNWEGSVQVWMSHGDQLSKAPEDFVVIAKTPTAPFAAMAHKSKPIYGVQFHPEVTHSLRGVELFDSFVDICACRRDWTMETFIDKEIKRIREIVGPKGQVLGAISGGVDSSVAAKLMHEAIGDRFHAVMVDNGVLRTNEAAQVYEMLSKDLGVNLTVVDASEQFLSRLKDVEDPEQKRKIIGNTFIHVFEAEVAKLEKQAEDEEAAALAAGKPQEAKGKFEYLLQGTLYPDVIESISFKGPSATIKTHHNVGGLLEDMKLKLIEPLRELFKDEVRALGKLLGIPAHLVGRHPFPGPGLAIRILGPVTREQVKILQHADSIYIDEIRAAGLYDQISQAFAVLLPVRAVGVQGDKRTYDQVIALRAAATTDFMTATWYPFPAEFLSKVSNRITNEVQGVNRVVLDISSKPPATIEWL
The following text describes a protein:
Function:
Inhibits tax-6/calcineurin A phosphatase activity and thereby negatively regulates calcineurin-mediated functions. Plays a role in modulating temperature-dependent calcium responses in AFD neurons and in addition, also negatively regulates thermotaxis in a tax-6-dependent manner in AFD neurons. In response to changes in intracellular calcium levels may also regulate nuclear translocation of transcriptional regulators such as crtc-1. May play a role in regulating body size. Plays a role in male tail tip morphogenesis.
Sequence:
MVADNSEKSTKSVANGSLISTVSSKDDLPNAIIVTQVPEDVFDNKQDKANFSSLFTQIEKDIHFDFLRSFRRVRVIFSSPENATAAKLIVQGFSFKGHELKAFFAQRIYMSANSQMLSPPPLEKQFLISPPCSPPVGWEQTKDMPPVVCNFDLMARLASFAIDEKYEVHNGDELTPAIIVHPCETPIDVPSAIEMPRTPRPSSPCEQ
The following text describes a protein:
Function:
Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Sequence:
MARYFRRRKFCRFTAENVVEIDYKDIATLKNYISESGKIVPSRITGTRAKYQRQLARAIKRARYLALLPYTDNHQ
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MAAAAVSDPLAELWKHIMSADRSDLLCFYPSKITMSGIWTGDSPMDFSLPLLLFQIILITSTTRAVALLLSPLRLPRYIAEILAGFLLGPSVLGRLPHFSDIAFPVRSLFILESMSLLGLIYYTFTIGVEIELHTVLRAGLRSFWFAASSALPPFLVGAAAGYVAVSTDDSRRTGAQFINSLSFPVFLGATFCSTAFSVLARNIAQLKLAGTDVGQLSISASLINDTFAWAGLTVATALAHVRYGMVPCLWTLVSGFLIVGTSYLVVRPMLLRLTRRVAEGEVVTELQECSVLVGVMVAALVADAGGTHAIFGAFVFGLAVPNGPVGVAIVEKVEDFVVGTLLPLFFAMSGLRTDTAKITSTPAVVLLMAAALVAAILKVVSAVSVAGVFGMPLHDGISIGLLLNTKGVIELVILNIGKNKKIMSDQSFTVLVFMSALITALVTPLLAMRRTIAWPQPNAEFHVLACVHMPRDVPALLTLLDVASPSERSPVAVQALHLIEFAGRSSALLLINASAPSSSLEHSAHGRSQVEQQFKHISHAFMAYEENAAGVTARTVAAVSPYVSMHDDVTSAAEDRHAALIVLPFHKHRSVDGGLEVFNPAIQPLNQSIQRFSPCTVGVLVDRGLGGVAGAGCTTRVAALFFGGRDDREVVALATRMVHNPAIDLTVLRFVQKGGSFAGSEFDALKERKADDACLREFLDRANGMSAGGGGGAGVEYRERGVFNASEMVAQVREVEALGKDLFVVGKTPGLPGLTAGMAEWSECPELGPIGDLLASRDFQTMASVLVLQSYARPGAMISAELGLGADGLPAAGRPPRPDQVRRNSIGNRS
The following text describes a protein:
Function:
Small polypeptide acting as a regulatory molecule which coordinates cellular responses required for differentiation, growth and development, probably by restricting polar cell proliferation in lateral organs and coordinating socket cell recruitment and differentiation at trichome sites.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MAEFKSKLNKGHAFTSKCASLVKEQRARLYILRRCATMLCCWYIQGDE
The following text describes a protein:
Function:
Di-iron-containing protein involved in the repair of iron-sulfur clusters.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFAQQKLSELAVSIPGATKIFREYDLDFCCGGSVLLEVAAQQKNLNLAEIEKRLTDLQQSKAENNDKDWTSASYAEMIDHIITRFHNRHREQLPELITLAEKVENIHGDRDDCPIGVVAQLEKIYAELSQHLMKEEQILFPMIKMGNYAMASMPIRVMEMEHDEAGQDVEVIKSLTNNCTPPADACFSWKALYSGINEFIDDLMHHIHLENNILFPRVLNEK