lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
RAB2B effector protein required for accurate acrosome formation and normal male fertility. In complex with RAB2A/RAB2B, seems to suppress excessive vesicle trafficking during acrosome formation.
Subcellular Localization:
Golgi apparatus.
Sequence:
MLSSFPHRKTWRKSKKTVKVTRSYPTFPSLNAWEEFRGLLPVDGEPNPGAGLGVEEGLLCRVVHSPEFNLFLDSVVFESNFIQVKRGRNWRDVYKASNTMALGVTSSVPCLPLPNILLMASVKWHQGQNQTWNRPSIAPNIFLKRILPLRFVELQVCDHYQRILQLRTVTEKIYYLKLHPDHPETVFHFWIRLVQILQKGLSITTKDPRILVTHCLVPKNCSSPSGDSKLVQKKLQASQPSESLIQLMTKGESEALSQIFADLHQQNQLSFRSSRKVETNKNSSGKDSSREDSIPCTCDLRWRASFTYGEWERENPSGLQPLSLLSTLAASTGPQLAPPIGNSI
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGRPKGDGNRSKTRPSSSSLAASLLPSGSANVGFGGFIGSSRLEFPQSTEEITPPDVDGEVAQHLKRLGRKDPITKLKALTSLCTLFKQKEGQEIVQIVPQWAFEYKKLLYDNNREVRRATHEAMTSLVATIGRGLAPHLKSLMGPWWFSQFDPVPEISQAARKSLQAAFPAQEKRLEALFLCTSDVFLYLDENLKLTPQAMSDKAVPKDELVEMHQRVISSSLLALATLIDIILGMKFQRSDTESATSERKNSAKAKAAVAAAAIVETMFTTHKRFLEILKSPSPGVRSATYTVLGSFIKHVPHVFGEGDMKVISSTILGSFQEKDPTCHSSMWDAILLLCKRFPECWSLCAVNKNVLPRFWSFLRHGCYGSQQISYPILITFLDCIPTKVLAGDKFLLDLFQNLWTGRSTCYSSADRMAFFKAFRECFLWGITHASRYVKREDDVTKFQLLLIERVLFMLLWREYFSGGNQVERDGLVGSINGLIGNNRDQNPESPLDMRNIKQSQSYIQDLGNYVAQILSDIFRKGHIMLDAFCVSFQRDCLEAIKQLGCPEKSTKHVEQIISFMWLLEKQAVQKGENWPLVYLVGPLLSESFPLIKSVDLPAAVKLLSVAVAIFGARSVVPWFLSYGREVSHKLFVDGEDSKLKPEVFLQIFEDDFVLWCLHGGDSSSLSARLDFLLSLLEDTLFYDQWRRILVHATNLEDLSQTDSNSLDVDRVGVLALLMEKVRRRTGNKEFGCESSDSKGYLPEHFQHELLDSAAVCVSRHPLGIYPSCARFLGAVLGGSAEDDHISLLSRNSLIIVFEELQKKLISLLMISSFTWSKYASSLLMYRETKDSLENPRLPIRVLDMAKFALEVLESSFFCLKNFDESCELVPCLLATTFFIKWESSMMTLHNLNISLESYRDKVDIEDLVSTLAVVVPDNIRAMIDLGESTHAIHSKIGVRFWRSLSLYSIQQLRNILIATIRFALFSEDVYETDKVFIVYSEWVVEILGLLSRDHDEEQAMLGHLLSQSDCWPLWVEPLDGEPAAVRLKIEHLCTDMQISRHHQFVAFVDKLVSRLGASKLIGGSFLENQSSSLSDAPVELVPSPSACYLRIWLAVEILCTWKWQGDSASGSLLPFFTECARRGKSSSEGKLLDSILIALLDGALLHGASIPLCSFNVWPASDEDVDKIQDPFLRVLVSLLLTLFIKNSIWGKADAYVFLEYLLNKLFIGSALNKCCLRILPYILNVLMIPLHMKHTMSDGTNRELPSDSPNEGWLQCSVSDWLQKSLTASPITLWPTGQPELEEWVQVALSCYPLGPTGGTSALNLDSSRDVSHEEKKLLLNLFRKQRSDKALGGRDTAVKVSLDICYSMENPLSLAVQMTLAKLLTVSVGYCSDEFDEDDWIFVLSQLRRWIEAIVVALEEMAETVDYALQSTPASDNSAGFLEKLEIAAQDLDSSSINIAKIALFIFSRICGLTKTEGDKFAKSLESLRTAMWENIRDRVFEDVLRMFFATGVAESIASSYAEQAASIVASTRHAHLSFWELVSATVVNSPHHANKVAVRSAELWGLSKGPISSLYAILFSSKPISSLQFAAYHILSTAPIQQLAITKEVGGLCLDDSGNEDLEKPRYAVSSSEEPFSLREEISCMINKTPSELGLDLEDQDLANYFVSWSLLLTYLESLPSLSPARERLIQYLQDSGSPSTILDYLFLHIPLKLGSSNNLKKRESDTSIETTRATSAAKEAIRTSSSFFVVKSLWPVGPEEVSSLAGAIYGLMLRLLPAFVRSWFTSLRDRSLSSAIEIFTKTWCSPDLLSDELSQIKGVVVADENLSISVNKSNYEVTAIYKKEEAGMDLVIRLPSCYPLRPVDVDCTRILGISETRQRKWMLSMAAFVRNQNGALAEAIHIWKSNVDKEFQGVEECPICYSIIHTTNHGLPRLACKTCKHKFHSACLYKWFSTSHKSTCPLCQTPF
The following text describes a protein:
Function:
Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it interacts with both DTNA and DES at the costamere.
Sequence:
MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSRQKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVSSQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVAAGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWEELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTPVKDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEASADSFPDTKVTYVDRKELPGERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGKSAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGPWGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPGGHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEGDLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETLPERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELSKDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGESEVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERMSYEGPTAEVVEVSAGGDLSQAASPTGASRSVRHVTLGPGQSPLSREVIFLGPAPACPEAWGSPEPGPAESSADMDGSGRHSTFGCRQFHAEKEIIFQGPISAAGKVGDYFATEESVGTQTSVRQLQLGPKEGFSGQIQFTAPLSDKVELGVIGDSVHMEGLPGSSTSIRHISIGPQRHQTTQQIVYHGLVPQLGESGDSESTVHGEGSADVHQATHSHTSGRQTVMTEKSTFQSVVSESPQEDSAEDTSGAEMTSGVSRSFRHIRLGPTETETSEHIAIRGPVSRTFVLAGSADSPELGKLADSSRTLRHIAPGPKETSFTFQMDVSNVEAIRSRTQEAGALGVSDRGSWRDADSRNDQAVGVSFKASAGEGDQAHREQGKEQAMFDKKVQLQRMVDQRSVISDEKKVALLYLDNEEEENDGHWF
The following text describes a protein:
Function:
Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.
Subcellular Localization:
Host nucleus.
Sequence:
MQTPKETLSERLSCVQDKIIDHYENDSKDIDSQIQYWQLIRWENAIFFAAREHGIQTLNHQVVPAYNISKSKAHKAIELQMALQGLAQSAYKTEDWTLQDTCEELWNTEPTHCFKKGGQTVQVYFDGNKDNCMTYVAWDSVYYMTDAGTWDKTATCVSHRGLYYVKEGYNTFYIEFKSECEKYGNTGTWEVHFGNNVIDCNDSMCSTSDDTVSATQLVKQLQHTPSPYSSTVSVGTAKTYGQTSAATRPGHCGLAEKQHCGPVNPLLGAATPTGNNKRRKLCSGNTTPIIHLKGDRNSLKCLRYRLRKHSDHYRDISSTWHWTGAGNEKTGILTVTYHSETQRTKFLNTVAIPDSVQILVGYMTM
The following text describes a protein:
Function:
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
Sequence:
MLEGVIRESITKANAKALKKDGYLIANVYGKGIENVNGAFKLNPFIKYLKEKKHLIFPVKLGDKTFEVVVQEYQKNPVTNELIHVDLLAVTKGVKSKFKVPIKHQGTPVGLKNKGILMLSKKRISVECAPEHLPDHYLVDVAPLDVNESILVRDLEKHENVKILDHDSIAVIGVIKAK
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
Subcellular Localization:
Nucleus.
Sequence:
MKKRDAVVVSDGVKKKKRKRSCSSSQSQLSNHPNTLFALLLASLSNSNSNSNTNQSFIKKCLFQFHPSLLLSNSSSSSSVTPILALLPTLLSSTHSPIARRAADITGAASLVSLEINEEIATDSETIKGLISLLENPDRKVLSSACNAILDLSTTAFAQQQLLNFSALHKLMSVFLQVFKRVESVCLLSEGNQSFHALKIGIREDELSVALLSAIIVLINVCNVEQLHNIPESVSEAFLSLLKEIRANATHHLVIRGDVKSNVEGRFCKSNVGVCDLADSIFRLSINASQLSVSLPFEVVQRGLFGTSGSSFEDFLSNHWEVSPFLLSRTSEDHNVNDMFSPFIQSLNWNGSVPSLLHSILQDLVSCFPIASEEQNILNFLIEVKDRLGCPIIYQQDIRVVKADSQSRKETHYFHPECHKEPLYFTNEDVLKCEQAYKEGYTVALRGLEFRYQRIASIADTLALMFGQPSVGANLYLTPANSQGLARHFDDHCVFVCQIFGSKKWTVFSRPGQLLPRLYDSLCGSDVDCTKAVRREFFLKEGDVLYIPRGFPHEAYTNYGVDDGSPGFSLHLTLSIEVEPAFEWEGVAHFALHCWNENQRRPCYGCINSLSQKLDLVSVNLLHVAIGIICTSNPTFRKACLTAAVSLPPDVYHRLIQKQRTTFLHLVDRICNECRFSEVLSNIEVAIQKNKDPFEHIRWLQVLRMEKEARSGFNTEKSFNIEDLCSLCTKHKDKLEAAFLNVKSRFCSEVVFEDVVTRHMMLLQKYKKTRRQYINGMLSLHDKL
The following text describes a protein:
Function:
Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the spindle poles only during mitosis. Sequestered to the nucleus during interphase.
Sequence:
MAFDTHHVKKRNFSNSIDLPRKRISNFTSKNMKEVKRSPKQLAAYISRTVAQAVKSPEKLRKVLYHRKLVRRSFPNPCYKTKQSPKSGGCDMANKENELACAGHLPENLRHDSRTFVINTSDSGSSQTESPSSKYSGFFSEVSQDHETMAQVLFSRNLRLNVALTFWRKRSISELVAYLVRIEDLGVVVDCLPVLTNSLQEEKQYISLGCCVDLLPLVKSLLQSRFEEYVIVGLNWLQAVIKRWWSELSSTSEIISDGNIKILKQQLSGLWEQESHLTLVPGYTGNIAKDVDAYLLQLH
The following text describes a protein:
Function:
Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MELSESVQKGFQMLADPRSFDSNAFTLLLRAAFQSLLDAQADEAVLDHPDLKHIDPVVLKHCHAAAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGSIGRSLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSYPEISFSCSMEQLQDLVGKLKDASKSLERATQL
The following text describes a protein:
Function:
Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MDLYYYNIRISLQLQISYHAYYTNLLIINFSYVSFYQQRSKWSECYDNFLRRYGITISLAQIRVTTTRLNRTFVQIGCYCTYLWKIWFTTGLCCGLVIMASSIFILTITAVRSLLPKKHTELLLTPVLPGINIGWSQLVYVIPAIAISGIFHELGHAIAAIRENVKVNGFGLFVMLIYPGAYVDLSSDHLSQISPYRQLKIYCAGAWHNIVLALLCIVLVKNLSIVLWPFYVTGGSIAVLNVFSGSPLYNVLERGDIITNINECPVQSISLWRSCLSDIQQQPLTGYCVDIRTLEKRYHHTVKGGPIFDCCNRTSSDLCFSFKSMHMQKRSKVCLNARNTSARSSCNTDLDCLTSQKSTCVIPVLPKDYRLLRIKRNRKKDVLYIDIPKNLLQAVSITNYLPRLSSLSVMIPDNVERFLLYIISFSAALALLNLVPAYALDGQWVLIALTDYFTTPSNRRTVNRLRSIIHIIGTGLLVLNVAIALRPLII
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Required for respiration and the maintenance of the mitochondrial compartment.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSFFKTAVRRFSSTSITRGMAKAIAYSEYGNPKEVLRAVSYNVPKCSKNQVNVRFLASPINPSDINQIQGVYPSKPPFTNDVCSSKPSAVAGNEGLVEVVDVGDQFKGTFSPGQWAILGSVNLGSWRTEMNIDGRSLVPVDKSAFPSIAEAATLSVNPCTAYCLLQHVVQLNKGDWFIQDGANSMVGIATIQLAKHFGYKSINVVRNRPDIEKLKEQLKSLGATIVITDEELMDRKTMKQKVPEWIQGGEVKLGIDCVSGRVAAEMAKYMSKGATMATFGGMSRQPLPVPVSLLIFKNLKFHGFWVTKWKSEHPEEFLKIIHKVEDFYRNGTLKTVNTELVSLKEDADEKTFLDTFLNAIEGHGKKIIKFEH
The following text describes a protein:
Function:
Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes.
Sequence:
MKKQYTVSTYLLDRLHELGIEHIFGVPGDYNLAFLDDVVAHENLKWIGNCNELNAAYAADGYARIKGIAALITTFGVGELSAINGIAGSYAENVPVIKITGTPPTKVMENGAIVHHTLGDGKFDHFSNMYREITVAQTNVTPEHAAEEIDRVLRACWNEKRPVHINLPIDVYNKPINKPTEPIINKPILSNKEALNKMLLHAISKINSAKKPVILADFEVDRFHAKENLHQFVEKTGFPIATLSMGKGIFPEKHPQFIGIYTGDVSSPYLRKRIDESDCIISIGVKLTDTITGGFTQGFTKEQVIEIHPYTVKIIDKKYGPVVMQDVLQHLSDSIEHRNKDTLDVKPFILESSPFTEEFIPKAQMVTQKRFWQQMYHFLQENDVLIVEQGTPFFGSSAIPLPNNTAYVGQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQVTAQELSTILRQNLKPIIFLINNNGYTVERAIHGQNQLYNDIQMWDYNKLSMVFGAEEKSLTFKVENEAELAAVLTNITFNKNQLIFIEVIMSQSDQPELLAKLGKRSGQQNS
The following text describes a protein:
Function:
Inhibitor of HGFAC. Also inhibits plasmin, and plasma and tissue kallikrein. Inhibits serine protease activity of TMPRSS13. Inhibits serine protease activity of ST14/matriptase and PRSS8/prostasin in vitro.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Domain:
This inhibitor contains two inhibitory domains.
Sequence:
MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERALRTVWSSGDDKEQLVKNTYVL
The following text describes a protein:
Function:
This protein is one of the chains of the nonenzymatic membrane component (F0) of mitochondrial ATPase.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MAAAWWNLASCRKPAPPTQARVVLTGVNISAAQAGTGTEVATMEQLTPEMGLPIELDLPAFSIQADFSCTACDAYALHEHLNVQDKKNEGKNRRRTATIASEGAAISIGNVLSSSIHSVAQNLSLAKQLFGYAILGFALTEAIASFAPMMAFLISFVFQVY
The following text describes a protein:
Function:
Tubulin-folding protein; involved in the final step of the tubulin folding pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MQVMEGSVDKISLIAQRDYDRKLGLQKQKETKESQSADTEKLAYFNETFSNKRQQIENFLTQSSDLDKAALPQHFDTISKEILLLQKYVANSNIFLRSYDIKKCHESLQELTNKLKQLEENLLPKKKFGFKNKQNVKPVETKKEKDEVDFHKVAIVAKECGFANKTGETLTMKNEIFKKDITVEKLENCTVKLFGSPSTLHLNQLKNCRVFTGPVSTSIFAENCTNCTLVIACQQLRLHSSSDVDIYLHVTSRAIMEDCHDIFLAPYNWDYDNLESDFKNSGLDRNTNNWKCVDDFNWLNVERQSPNWSLLDEGKLVKNWDNS
The following text describes a protein:
Function:
Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MAHTSSEDSDHEVPGNMDEGDENTIKILVATDCHVGYMEKDFIRHSDSIDTFEEILQLAQKNKVDMVLIGGNLFHENTPSKRSLHGVMTLLRKYCMGDRPVQIEFLSDQSVNFAASPFPNVNCEDPNLNIDMPIFSIHGNHDDPRGLGTLSALDMLSACGLVNYFGKSTSLESVEISPILIQKGITKLAMFGLGSIRDERLHRMFLSGKISMLRPKQNADSWFNIFVIHQNRAKRSRNNYIPAQFLDNFIDLVIWGREHECLIDPVWNATQNFFISQPGSSIATSLTPGEAVPKHVGLLQVCGKAMKCTKLKLETVRPFYIEDIALQDTTLDRDDVNAFCTEKVEALIQRAEDEHTGNRKQPTLPLIRLQVDCREWYNKLNGKRFGQKFVGRVANKDDFVWCSKRRIQGQTKEDTEPVEDLEEFFKLEALGTERHEDSVCKYFSGTEEVCDHCRYGAAHCCALRLLMEGAFVEKDLIALRISFGMFGFGGRAFCRMASTSLRTESAVSASRVLIEDSTLATISVTGIRLGATAKLRPFFNGILGRCQIWTTFSLSSAERILAMSAAVESNSALAEFLTKQLELLSEKFLGLAVREYVDKEKKEAIRIVVKHQLSQTQGQLMNQGTTKDHIDDEIKDLRKYRVHAGGKKKEAKNKKGRARNKKDGVQEDAVLTMTWRIEALIQ
The following text describes a protein:
Function:
Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. Recruits the BUB1-BUB3 complex to kinetochores when phosphorylated by MPS1, to support spindle assembly checkpoint signaling; the effect is reversed by protein phosphatase 1 (PP1). The KNL1 complex is required for kinetochore binding by the kMAPs (kinetochore-bound microtubule-associated proteins) BIM1, BIK1 and SLK19, and motors CIN8 and KAR3.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MNVDERSRIGGREKDAGPGKGILKQNQSSQMTSSFLENPGVRIPTRIITKKEVLDGSNTTSRINTSNLQSMVKRRVSFAPDVTLHSFTFVPEQNNEIKEPRRRKTSTNSPTKISSQEEPLVTSTQIDDARTEEKTAAEEDPDTSGMELTEPIVATPDSNKASQHDPTSMEMTEVFPRSIRQKNPDVEGESIESSQQIDDVEAVREETMELTAIHNVHDYDSISKDTVEGEPIDLTEYESKPYVPNSVSRSTGKSSDYSVERSNDKSDLSKSENKTNSSQPMEITDIFHADPQNPMSLHSDNNINNDGNEMELTQIQTNFDRDNHHIDESPSEKHAFSSNKRRKLDTVSDYAASVTTPVKEAKDTSGEDNDGDLEMMEKMSPITFSDVDNKIGTRSNDVFTIEPGTEDTGMQTATDDEEDGENVDDNGNKIVEKTRLPEIDKEGQSGIALPTQDYTLREFINEVGVGFLDTKLIDDLDKKVNFPLNSFNFVENQRIDNVFSAFYIDIPILEVEAFRCKELWRSINESKDKFKDFEAQIDKSHPPLLLQEYFSSDEKMKQLMRDQLQLVKGYSKLEAAMEWYEWRKKQLNGLELILAENLNTLKREYEKLNEEVEKVNSIRGKIRKLNEAIKEEIRSLKNLPSDSYKPTLMNRIKIEAFKQELMEHSISLSSSNDFTQEMRSLKLAIAKKSNDILTLRSEVASIDKKIEKRKLFTRFDLPKLRDTLKILESLTGVRFLKFSKATLSIAFLQLDDLRVDINLANFKNNPLSSMKVMNDSNNDDMSYHLFTMLLKNVEAEHQDSMLSNLFFAMKKWRPLLKYIKLLKLLFPVKITQTEEEEALLQFKDYDRRNKTAFFYVISLVSFAQGVFSENGQIPMKVHISTQQDYSPSREVLSDRITHKISGVLPSFTKSRIHLEFT
The following text describes a protein:
Function:
Probable transcription factor involved in somatic embryogenesis. Acts as a positive regulator of BHLH109.
Subcellular Localization:
Nucleus.
Sequence:
MFYTNMETVHNCFNDATITGDEIIDILAFLQSDESDNPSGINEVVPVDDKKRRRTISNRESAKRSRMKKKKRFEELTEEVNRLNIRNQELKNRLANVVSCGNFISRENNRLKTESVCLEIRLLELYRFLVAMQSPISTSVNYITTLEI
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDPASFSDEDSSSVSRSGDGRIDQESSGRRGQQPSSRDDIIDESDGGDVNSDGSSGDEYAAKRISNFEDLPTDDSEEDSDSDDDDSDDDDDSSVEENAKGKQAIDEVNNEDVPLGERVASQAKLGRRYYTGDDDLGDKSSKYNDDGGKRQRAERKSKAIVLATQRLKDARKKNATKNKKREASDCNSDNESVEGGSNSEQPKRKKSKHAPTEMSSKRRDFFARKPDLNSSGVGISIGANRYKPRDPRMVTLSGHLDQDTFDKRYGFLDEMQDQEIETLKKRVNARQIKGRRGTRARRKLGIDGFGNLEEDKEELTRLTQERAERKRAQVTRAAKRSVKKKIRDDVASGKRGAYYPKRNELRKMEVEARFEEIRKRGGDEAVDKAIAKRRKKNVAKSHKLMPTHKV
The following text describes a protein:
Function:
Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.
Sequence:
MARTGPRGERLTRAQQERLLKHELKGLGHQLEKLEKKAKADQATQDLPELDDHMLEELYQALMLPPPPTAEEARLARLEGGRRERGLQRCAEQDGRGRRMLGIMEGPMALLSPTKADERRMRAGMDLKQKMIDAREKGKMLLPPSSSPVRRTQEFPTAELPETKRASVQEEQIDMVALPYAERQEIRLQQLFARLSLVHSTSDASTAESESGTDSLQDIKSNLAHRIAKILQEHDYKLQSASPDSAEKNTAEAEEEDPASPPPPFAPVRLDGRASALSAAKNDQMPPETKGNSAANSRDDVVAHAETMINDLSSTESRQFLLDSIEKLVLSASASTTDSTTVAPLPLGIATTEEWTALAVSSAQANDTATLSRTMSLMQAAGYHPAPLELYNNVMDAFATNGQVELCQEWLQQMSEVGLVPDDHTYHSLTKAYVNTSQFVPAIQLINSLEASGRPASMATYTLIIDRLLDPVVAPATGVKDERPELQALAWNVFYHMRLHAHPVPDVPLYTLMIRACARGIPQPHDIDDALGSSTISASRARPSSRISDAERALDLFREMTTRYSVRPNAEVYNALILACARRKDFYLEAFRLLREMVELETERSHINAGHGGMLRFAPDRYTFNALLQGCARNRDLARARWVLAEMIRSTLPLFDAEVSQGLTRAQSVELLSKRPNEETMCHVLHTYAAYVPPVKRTQLASQAQSREEPPSGAATPLSSSTLSNTDKTDDIVTDAHHAIVASEVHQDENTTAEEAAHIFSALVPQTSSDLVSESRSLFARILADQPTSDIQGPLGAVTPGVRLVNAYLTVLAAHLPRHQRPSVLHSTLLNVEQSDSQEHASLECALFAKLRLEPNEHSYRIVLQSLSEAGAESARLVNEVWDKFQEFMGKHTTATEGGLTAVARGGESAQGAEPIDAVEVTKCWSAYIHYHAKTSTASNDKIGLDRAMALVREYVCLYPPQLSPDMAARSGRRKALKKARIRQMASLREHSSKTRLDLTPLPVPWKSLQTLIALSDRSDPLGFKDNTSSVNTASDCLRTQPPATLPLSFPPSFSFLDVQLLHHRLVRYGRTKDLAYLSWVLHRYAAARRSRGS
The following text describes a protein:
Function:
Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses. Also promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus. Endoplasmic reticulum. Lipid droplet. Mitochondrion. Mitochondrion inner membrane. Mitochondrion outer membrane.
Domain:
The N-terminal region (1-41) is necessary for its localization to the endoplasmic reticulum membrane and lipid droplet.
Sequence:
MLVPTALAARLLSLFQQQLGSLWSGLAMLFCWLRIALGWPDPGKGQPRVRGEPKETQETHEDPGSAQPTTPVSVNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKRGLLLLKQAGMEKINFSGGEPFLQDRGEYLGKLVRFCKEELALPSVSIVSNGSLIRERWFKDYGDYLDILAISCDSFDEQVNVLIGRGQGKKNHVENLQKLRKWCRDYKVAFKINSVINRFNVDEDMNEHIKALSPVRWKVFQCLLIEGENSGEDALREAERFLISNEEFEAFLQRHKDVSCLVPESNQKMKDSYLILDEYMRFLNCTGGRKDPSRSILDVGVEEAIKFSGFDEKMFLKRGGKYVWSKADLKLDW
The following text describes a protein:
Function:
Component of Salmonella pathogenicity island 2 (SPI-2) type III secretion system, required for secretion of some type III-secreted effectors including the SpvB toxin.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRSWLGEGVRAQQWLSVCAGRQDMVLATVLLIAIVMMLLPLPTWMVDILITINLMFSVILLLIAIYLSDPLDLSVFPSLLLITTLYRLSLTISTSRLVLLQHNAGNIVDAFGKFVVGGNLTVGLVVFTIITIVQFIVITKGIERVAEVSARFSLDGMPGKQMSIDGDLRAGVIDADHARTLRQHVQQESRFLGAMDGAMKFVKGDTIAGIIVVLVNIIGGIIIAIVQYDMSMSEAVHTYSVLSIGDGLCGQIPSLLISLSAGIIVTRVPGEKRQNLATELSSQIARQPQSLILTAVVLMLLALIPGFPFITLAFFSALLALPIILIRRKKSVVSANGVEAPEKDSMVPGACPLILRLSPTLHSADLIRDIDAMRWFLFEDTGVPLPEVNIEVLPEPTEKLTVLLYQEPVFSLSIPAQADYLLIGADASVVGDSQTLPNGMGQICWLTKDMAHKAQGFGLDVFAGSQRISALLKCVLLRHMGEFIGVQETRYLMNAMEKNYSELVKELQRQLPINKIAETLQRLVSERVSIRDLRLIFGTLIDWAPREKDVLMLTEYVRIALRRHILRRLNPEGKPLPILRIGEGIENLVRESIRQTAMGTYTALSSRHKTQILQLIEQALKQSAKLFIVTSVDTRRFLRKITEATLFDVPILSWQELGEESLIQVVESIDLSEEELADNEE
The following text describes a protein:
Function:
Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGKASKDKRDIYYRKAKEEGWRARSAFKLLQIDQEFNIFHGVKRVVDLCAAPGSWSQVLSRNLYVPAKQSPDCKEGDLPLIVAIDLQPMAPIEGVIQVQGDITNARTAEVVIRHFDGCKADLVVCDGAPDVTGLHDMDEFVQSQLILAALTIVTHVLKVGGKFVAKIFRGKDTSLLYCQLKLFFSQVTFAKPKSSRNSSIEAFAVCENYSPPEGFKEEDLYHLLEKVGTPSGVDDLDCRSGWLEGPNKVYIPFLACGDLSGYDSDRSYPLPITDGGSYRSLDPVQPPIAPPYKTALQMKKASSHSASRDAMKPSTDS