lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Oleoyl-12-hydroxylase involved in the biosynthesis of ricinoleate (12-hydroxy-cis-9-octadecenoate), the major fatty acid constituent of the oil seeds from castor bean plants. Catalyzes the hydroxylation at the 12-position of 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine (2-oleoyl-PC), which seems to be the actual physiological subtrate. It uses cytochrome b5 as an electron donor. May also be involved in the production of lesquerolic acid (14-hydroxyeicos-cis-ll-enoic acid) in vitro.
Subcellular Localization:
Microsome membrane; Multi-pass membrane protein.
Domain:
The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence:
MGGGGRMSTVITSNNSEKKGGSSHLKRAPHTKPPFTLGDLKRAIPPHCFERSFVRSFSYVAYDVCLSFLFYSIATNFFPYISSPLSYVAWLVYWLFQGCILTGLWVIGHECGHHAFSEYQLADDIVGLIVHSALLVPYFSWKYSHRRHHSNIGSLERDEVFVPKSKSKISWYSKYLNNPPGRVLTLAATLLLGWPLYLAFNVSGRPYDRFACHYDPYGPIFSERERLQIYIADLGIFATTFVLYQATMAKGLAWVMRIYGVPLLIVNCFLVMITYLQHTHPAIPRYGSSEWDWLRGAMVTVDRDYGVLNKVFHNIADTHVAHHLFATVPHYHAMEATKAIKPIMGEYYRYDGTPFYKALWREAKECLFVEPDEGAPTQGVFWYRNKY
The following text describes a protein:
Function:
Acts as a magnesium transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MKEGIKLEEIIQLLEQNRLAELKEILIKENPIDVADVFEEFPKEKDLIIFKLLPKDFSSEVFSYLSPEKQQEVIENITDEEIKFIMEDMYLDDTVDFIEEMPANIVDKILKNTSHDKRKLINQMLKYPENSAGSVMTVEYISFKDNYTVKQAIDYYRKIAIDKEETDICFVTDSKKKLVGIISLKTLILSNDDSYIKDEMDTNFVSVLTKDDQEETAALFRKYDLTTMPVVDHEDRLVGVITVDDIVDVIDQENTEDIQKMAAMNPSDEEYLKESVISLAKHRIIWLLVLMISATFTGLVIKKYEEVLQSAVYLAVFIPMLMDTGGNAGSQSATLVIRGIALEEIEFSDIFKVIWKELRVSVLVGFILSGINFLRIYYFTKSGFETSLVVAISMFLTIIMAKVIGGVLPLIAKSLKIDPAIMASPLITTIVDTAALIIYFQLSVIFLHI
The following text describes a protein:
Function:
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
Sequence:
MTKIIFMGTPDFSTTVLEMLIAEHDVIAVVTQPDRPVGRKRVMTPPPVKKVAMKYDLPVYQPEKLSGSEELEQLLQLDVDLIVTAAFGQLLPESLLALPNLGAINVHASLLPKYRGGAPIHQAIIDGEQETGITIMYMVKKLDAGNIISQQAIKIEENDNVGTMHDKLSVLGADLLKETLPSIIEGTNESVPQDDTQATFASNIRREDERISWNKPGRQVFNQIRGLSPWPVAYTTMDDTNLKIYDAELVETNKINEPGTIIETTKKAIIVATNDNEAVAIKDMQLAGKKRMLAANYLSGAQNTLVGKKLI
The following text describes a protein:
Function:
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVVSVLGLDVGSKRIGVAGCDPTGLIASGLETIVRCNLGADLDAIRHWIERRRAQAVVIGLPRNMNGSLGPQAHRIQHFGQQLARVIDVPIDYVDERLSTVQAGRALQSVSATRRKALIDQQAAAIILQQWLDIRRCQHRPTQESLDERHIDTER
The following text describes a protein:
Function:
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MALLSMVAIFKCFLHSLTCCIPLLYLSIKCCQTCAFVLIYLSAFPPLLLMSHCFMFPAGKTTFVKRHLTGEFEKKYEPTIGVEVHPLDFSTNCGKIRFYCWDTAGQEKFGGLRDGYYIHGQCAIIMFDVTSRLTYKNVPTWHRDLCRVCENIPIVLCGNKVDVKNRQVKAKQVTFHRKKNLQYYEISAKSNYNFEKPFLYLARKLAGDQNLHFVEAVALKPPEVQIDMAMQQQHEAELAAAAAQPLPDDDDDLIE
The following text describes a protein:
Function:
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.
Sequence:
MTTDNLNQPHLSPVSSFSAGAGSDGVPYSRNHALTNTNNAAAAAAAAGYPRGQQQSTTLSTVSPGRSAPVRGVASQQASTSTSITLSSSDANVVAARPSATTASTPNPNSTSNALAHQQQSNLRSSWHRPYSSGVPAPAVAVPIFRAAHPATIPALSNNAHRNVTAAQLPDSPPDTPPHSPGLAPVRLPSLGELGRLPQSQRPSPSRHFDVHERAPRSWSRPLPAHARDADISTDVIYTGQTPCDSELESVAESDFSDDTSQATIDQLVQAAQSLLLSSAPDRTNPQHALGPESANVSSIATQRGELMPATPEISPDNDVRHHAQKSAHAFLHRIFANVPGDLSVEDAGVELISPGWSGAVIKSGAIAPTQPSSSISSTSSSDSSADSQRTLYVSMPSVVDATLLREQVLAVLDAASDKLGCDSVMVCLNKAMRDFASVLHGLCYVGGALVAAAKESDQLGGGHANLPETDPISGLQLQNGLVLVAIEL
The following text describes a protein:
Function:
Binds DNA and acts as a transcriptional repressor (By similarity). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (By similarity). May play a role in neurite elongation and survival (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Cell projection, dendrite. Synapse. Note=Localizes away from the nucleus to neurite processes and synaptic termini as cerebellar granular neurons differentiate (By similarity). Accumulates in the cytoplasm of differentiated Purkinje cells (By similarity). Localized to both the cytoplasm and nucleus in immature cerebellar granular neurons and atrophic Purkinje cells (By similarity).
Sequence:
MSGGKKKSSFQITSVTTDYEGPGSPGASDPPAPPAPAGPPPRLPNGEPNPDPGGRGTPRNGSPPPGAPASRFRVVKLPQGLGEPYRRGRWTCVDVYERDLEPPSFGRLLEGIRGASGGTGGRSLDSRLELASLGISTPIPQPGLSQGPTSWLRPPPTSPGPQARSFTGGLGQLAGPGKAKVETPPLSASPPQQRPPGPGTGDSAQTLPSLRVEVESGGLAAGTPPLSRRRDGAVRLRMELVAPEETGKVPPIDSRPNSPALYFDASLVHKSPDPFGAAAAQSLSLARSMLAISGHLDSDDDSGSGSLVGIDNKIEQAMDLVKSHLMFAVREEVEVLKEQIRDLAERNAALEQENGLLRALASPEQLAQLPSSGLPRLGPSAPNGPSI
The following text describes a protein:
Function:
Catalyzes the conversion of 1-deoxypentalenic acid to 11-beta-hydroxy-1-deoxypentalenic acid in the biosynthesis of neopentalenolactone antibiotic.
Miscellaneous:
MISCELLANEOUS: S.avermitilis does not produce pentalenolactone itself in vivo but instead a group of new metabolites that are neopentalenolactone derivatives.
Sequence:
MTNVTGDYTDCTPLLGDRAALDSFYEEHGYLFLRNVLDRDLVKTVAEQMREGLVALGAADPHATLEELTIDSFESVDEVAMHDYVKYDAFWNNPSTIKVFEQVFGEPVFVFLSTTIRYYPSQAGSEEPSFHYLTPFHQDGFYIGPNQDFRTFWIPLIRTTRESGGVALADGSHRRGKRDHVLNESFRRFGHPVRGIPPTEVSEDEHLLHSPMEPGDILLFHAHMCHKSIPNLSKDPRLMRMSMDTRVQPAKSHRGFNAMTPWTESAKDASKGIMAKITGTPTDVE
The following text describes a protein:
Function:
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
Subcellular Localization:
Cytoplasm.
Sequence:
MTLGSETKTDVEVPIINGKHEIPQEENDSGHSSINTPDSSEPDKQVDKFVKITIQPSCGDAFELHLSDNELVQELYQTLLDREATCHRTCFSLYLNGTAVDNYSEVRAIPGFVDGCTLNVVDEPYTIRDARLHLRQVRELLKFGLTEDQHEPPCTNDAQSYLTTINLQPEEKKEPKPSDILPPDHALPGCKERSLAHLLVPQPKELIALKDIAFSPYNPPPGPRKLRGDVLYIDITTVENRIYHVTCCTRGFYVNNSQDGRFDPTVSNSNKTVYQSVIELLQNVSPGFKKVYPQILKRRQEKTLVERLPTSYPVSSWVGNPLKTDGYMSDSLRAIELTEPFRVGFEDHMPGLLRDWNEELQTTFEMTRKSISERVIRDRSYYKIHADYVNAAARGVQSILDGNILAINPGEDKKTHMYIWNNIFFSLGFDVRDHYKELGGDAAAFAATSTDLQGVRAFATLDDPKLNTLGMAIFDYRGYRVTAQSIIPGILEREQEQSVVYGSIDFGKTVVSDEKYHELLEDAAHKLKMLPHTVISEKDGVKEELKLYTSYEAKGIIGNDGRKYVLDLLRSMPPDVHYLDDAEVSEAAKTLGYPRKFPHKLSALRRELIDAFCESRLVTFIQLTAKKIRDLITESKEKNDETLIKQAAEAETELSLLFMAISEDKEFEAKNKVVQDAIKEACAVVHSIYEDRYVMKFNPDCFSSNVKHAPTENLERQRRVVVDAADFLLTQKIPELVQNLKDCVVQPIDGDNLADIMHINGINIRYLGEIGKRLENSVSFARPLVLSDIVARSAKHVIRKINVQITADQLSASTSHILNCLFSVVLDPSPIAANVAKKANKKNGKKRVTSAWSSLTTSALWNSIREDSASYYGYPIEADSLEKFTELHDIQKTALFRRICKVMGVQLVARDYQLDNSTAKKTSIFVEDDIINFFPIIKHHEPFTADAKKMFIRGQQAMSIGASREAYECIGESLNLMTLVYGVMHPDMPQCLRALARLSHVLGETGDALNNQHKAAVMSERLIGLDAGNTIIEYINLAHFAFGALLIPGSLRPLYRARYLMNLVFGEKHPVMAQIDANIGLILFTVQEFDTALKYLQSADAITKTIGEPRKLKTGLISNLIARTHAARGDFRAALVAEKETFAIYSELYGPNHPRVNESSEYLRTLTQQAVTFQKKMLKLDNSTNITELFQAQPPTVTSLFDTLNIINGILIIGVPGLSSLGKQQNGTTEESKTTDVAAQLDNETLD
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAVALGCAIQASLNQGSVFQEYDTDCEVFRQRFRQFQYKEAAGPHEAFNKLWELCCQWLKPKMRSKEQILELLVLEQFLTILPTEIETWVREHCPENRERVVSLIEDLQRELEIPEQQIDRQEMLLEELAPVGTAHMPPDIHLESPPLQVMGPGPEAPVAEAWMPQAGPQELGFGAAGACQPFLDPGYPLPKLDVSFPLEHREEAWVKELQDSKEIKQLLDSKIGFEIGIENEEDPSKQKKMENMYPFIVTLEGNALHGPILQKDYVQLENQWETPPEDLQTELTKLVDHQNPSAGEKPESSNLEEPLNPRPHKKKNPGDKPHRCSQCGKCFARKSQLTGHQRIHSGEEPHKCPECGKRFLRSSDLYRHQRLHTGERPYECTVCKKRFTRRSHLIGHQRTHSEEETYKCLECGKSFCHGSSLKRHLKTHSGEKPHRCHNCGKSFSRLTALTLHQRTHTEERPFKCNYCGKSFRQRPSLVIHLRIHTGEKPYKCSHCSKSFRQRAGLIMHQVTHFRGLL
The following text describes a protein:
Function:
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MSSMGTLAFDEYGRPFLIIKDQERKSRLMGLEALKSHIMAAKAVSNTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARIAIEHLDKISESFPVDVGNTEPLIQTAKTTLGSKVVNSCHQQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTQLIKGVIVDKDFSHPQMPKEVKNARIAILTCPFEPPKPKTKHKLDVTSVEDYRALQKYEKEKFEEMIEQIKLTGANLAICQWGFDDEANHLLLQNKLPAVRWVGGPEIELIAIATGGRIVPRFSELTSEKLGFAGLVKEISFGTTKDKMLVIEKCRNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLVRDNRVVYGGGAAEISCALAVSEEADKCPSLEQYAMRAFADALEVIPMALSENSGMNPIQTMTDVRARQVKEMNPALGIDCLHKGTNDMRQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLELELSRKWDQCLADAVVKIGRMWPLAFGSGMGLGMAYSNCQHDFQAPYLLHGKYVKEQEQ
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MVESDSSGIVRHSQGEFDIVQVYKKFLQDDPEITMPVAAIEALVQLLSRSQAKTISEFMDILQNGSNTLKEGVQNNISLSAGCDIFQRFVTRSLHDVGDFEQCKRHLVENGKLFIQRARACRQRIAHLGYPLIRDGSVILTHGFSRGVAAVLLAAAKRHVRFKVFVTESRPSGSGCLMTRTLKNACIPTCMVLDSAVSFTMNRVDLVLVGAEGVVENGGLINQIGTFQLAVFAKHAHKPFYAVAESHKFVRMFPLSQYDIPFSRPILEFDDPSPETVHPEPEPIPTPSDAIHNELIMNEEQIRNNPTLDVTPPEFVSGLITDLGIIDSKSGVSEELIKLYL
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes; Regulates also the sphingolipid metabolism.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MELRCIHCGFPIKTLFLQYSPGNIRLMKCENCKAVADEYIECESMIVLIDLILHKPKAYRHLLFNLLNPQTLNFQGLLWKSALGFLLLDAYRILVLTRSEEEWGLSMSFSSLFWRFSKILMDVLFGNLAFLSIFLLATRNLLNTVGGASRYKNLLLAILISSYFKIFLIAMMVWELPSSVIFIIDVFVLSSNTVALKVVTGSGMSRCAETCFVAHAVKLFVSQLTVFHSSRFLQDSKILTCEMPIYSM
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.
Sequence:
MGSSDVVIAGAGIIGLSIANRFLRQTNLSVTVVEAAHKICAGATGAGQGYIWSGHLNPDSKTWDFSRRSIQLWHEFVAEIQASGVDPLEKIGWRDTGSLLFTTGGEESLALHNRLHKVAAAGVQVEFWNSHTAQTAEPALVLGPEGAAAFFPADCQIDARAAVEFIQQENRALGPGGRYKEVFGSPVTGFRRSPADRYMQGLQTLNGDLHSKRAVIVAAGAWSSDLLEILSKRFDLDLTPSIRPRKGHLLVVDKTAGLHLNYGTMEFAYTSTKNSKETLDEFGVATTATVDPAGNVLLGSSREFKGFDITPDEAVIQQILHRAAKFFPALASVPLSSIHPRTGLRPYTPGGVPLIGPIVELPGLFLASGHEGSGLSLALGTAEMIVDTIMERSSSAIFQWSV
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates basipetal PIN proteins (e.g. PIN1) polarization to establish inward auxin transport from the L1 surface of incipient organ primordia; this process is essential for the progression of flower organs development. Recruited to the plasma membrane by PINs (e.g. PIN1 and PIN2) and, in concert with AGC kinases-mediated (e.g. D6PK and PID) PINs phosphorylation, maintains their polarity through limiting lateral diffusion-based escape. Influences cotyledon development by regulating auxin distribution mainly in the provascular tissue. Plays an essential role in auxin-mediated organogenesis and in root gravitropic responses through the control of PIN proteins (e.g. PIN1 and PIN2) polarity in the root tip endodermal cell layer and in shoot epidermis and in inflorescences.
Subcellular Localization:
Cell membrane. Cytoplasm, cytosol. Note=Polar localization at the cell periphery almost identical to PIN proteins polarity, in the upper side of the plasma membrane towards the tips of cotyledon primordia in the protodermal cells and in root epidermis, and in the basal side of provascular cells, root stele, pericycle, endodermis and cortex, and in radicle tip cells. Weakly observed in the cytosol of root tip quiescent center (QC) and columella cells, sometimes close to the basal side of the plasma membrane.
Domain:
The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.
Sequence:
MKFMKLGSKPDSFQSDEDCVRYVATELATDVVVIVGDVKFHLHKFPLLSKSARLQKLIATTTTDEQSDDDEIRIPDIPGGPPAFEICAKFCYGMAVTLNAYNVVAVRCAAEYLEMYESIENGNLVYKMEVFLNSSVLRSWKDSIIVLQTTRSFYPWSEDVKLDVRCLESIALKAAMDPARVDWSYTYNRRKLLPPEMNNNSVPRDWWVEDLAELSIDLFKRVVSTIRRKGGVLPEVIGEALEVYAAKRIPGFMIQNDDNDDEEDVMEQRSLLETLVSMLPSEKQSVSCGFLIKLLKSSVSFECGEEERKELSRRIGEKLEEANVGDLLIRAPEGGETVYDIDIVETLIDEFVTQTEKRDELDCSDDINDSSKANVAKLIDGYLAEISRIETNLSTTKFITIAEKVSTFPRQSHDGVYRAIDMFLKQHPGITKSEKKSSSKLMDCRKLSPEACAHAVQNERLPLRVVVQILFFEQVRATTKPSLPPSGSHGSSRTTTEEECESVTATEETTTTTRDKTSSSEKTKAKGVVMSRIFSKLWTGKDKDGVGDVSSSDTSESPGSVTTVGDKSTPSTRRRRSSS
The following text describes a protein:
Function:
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAATMAAQSLLSIPVEYRSQVWCRANLPYPPAPQLPIPAVVDILTKASQALPQISFSWTLIDQPPDGSLFLVWQAPTLPSPPDGMHFMSNERFFNMDVAGKVLEIHEAKHGFYPLSETRTMHVRCRYRLLGVGFDNFWLVHYFQGSETDSIPANISVAKPPHLRRYPLPDVKTSPFLLQEPKKHIPEGTALSQRETLPNMGSAQMKSQSRTPSFSNVTTSPVPPINSNATAQTAEGHMGATNMTVDNMNKPSIPPNGNTSILMQEDLEIEKGDVMDKLSPQQICTARFIKHAEWMSQVLLTLQSVKDIEPPALWQEPNSMEELGKELKDNKEQLVKQDQKYQSLQGDLSYTDSMSNLLKEFSNIKSAEECDVLQKKIEEFAEAKIVPLSHVTERS
The following text describes a protein:
Function:
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Positively regulates FAB1 kinase activity. Major activator of FAB1 during hyperosmotic shock and can elevate levels of PtdIns(3,5)P2 in the absence of VAC14 and FIG4. Directly involved in vacuolar membrane scission. Required for normal vacuole acidification, inheritance and morphology.
Subcellular Localization:
Vacuole membrane; Single-pass type II membrane protein.
Sequence:
MTEEDRKLTVETETVEAPVANNLLLSNNSNVVAPNPSIPSASTSTSPLHREIVDDSVATANTTSNVVQHNLPTIDNNLMDSDATSHNQDHWHSDINRAGTSMSTSDIPTDLHLEHIGSVSSTNNNSNNALINHNPLSSHLSNPSSSLRNKKSSLLVASNPAFASDVELSKKKPAVISNNMPTSNIALYQTARSANIHGPSSTSASKAFRKASAFSNNTAPSTSNNIGSNTPPAPLLPLPSLSQQNKPKIIERPTMHVTNSREILLGENLLDDTKAKNAPANSTTHDNGPVANDGLRIPNHSNADDNENNNKMKKNKNINSGKNERNDDTSKICTTSTKTAPSTAPLGSTDNTQALTASVSSSNADNHNNNKKKTSSNNNGNNSNSASNKTNADIKNSNADLSASTSNNNAINDDSHESNSEKPTKADFFAARLATAVGENEISDSEETFVYESAANSTKNLIFPDSSSQQQQQQQQPPKQQQQQQNHGITSKISAPLLNNNKKLLSRLKNSRHISTGAILNNTIATISTNPNLNSNVMQNNNNLMSGHNHLDELSSIKQEPPHQLQQQQPPMDVQSVDSYTSDNPDSNVIAKSPDKRSSLVSLSKVSPHLLSSTSSNGNTISCPNVATNSQELEPNNDISTKKSLSNSTLRHSSANRNSNYGDNKRPLRTTVSKIFDSNPNGAPLRRYSGVPDHVNLEDYIEQPHNYPTMQNSVKKDEFYNSRNNKFPHGLNFYGDNNVIEEENNGDSSNVNRPQHTNLQHEFIPEDNESDENDIHSMFYYNHKNDLETKPLISDYGEDEDVDDYDRPNATFNSYYGSASNTHELPLHGRMPSRSNNDYYDFMVGNNTGNNNQLNEYTPLRMKRGQRHLSRTNNSIMNGSIHMNGNDDVTHSNINNNDIVGYSPHNFYSRKSPFVKVKNFLYLAFVISSLLMTGFILGFLLATNKELQDVDVVVMDNVISSSDELIFDITVSAFNPGFFSISVSQVDLDIFAKSSYLKCDSNGDCTVMEQERKILQITTNLSLVEESANNDISGGNIETVLLGTAKKLETPLKFQGGAFNRNYDVSVSSVKLLSPGSREAKHENDDDDDDDGDDGDDENNTNERQYKSKPNARDDKEDDTKKWKLLIKHDYELIVRGSMKYEVPFFNTQKSTAIQKDSMVHPGKK
The following text describes a protein:
Function:
Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates.
Sequence:
MVSKSFKYPKKHKFEWINETNRVERVGSGLKRVILCPSMELIAILTCSNHLICCRSNSQRIWDVDFHDLEATELCWNHDGNLIVVGFKNGELKIIDSSTGHLVEQRPASRDLAVLMITWAMQETIVNEKRNDFLFDATAYMPLLGTLPSSAKEERIFSSKAIAQFFEPRKREGENNKKVELLSILDERGIRYINMFSSYKIGESDSLKSALNLGVPISHSITNDLAYHVLICKGGTNISLKTLYMPLLKNDLGSIVDIATMSTRMQHLVRYLEEVLNAMYEEFDNVFKSEASFIKTFDALVSKYSDTTFFSLQLELYQFIMNGIPSDLLKEWINERVGDRVLKNWERAMVNSYTSLIIFCQEFVIPACERLTVLLSSARGKSIWGHMKGNTLLDAKLVEDCLATLGYLQNNVFSFLNCLFEEKKYMKHFISWLNYAIVEFNTSEPSSIPPQEIIEHINETVIYIRHSLFRSKLTSYFMGTKPLQLRDPDYYSLKDFANQDDSNSVDDFVSFKTLKESLRDSFNVIFSYPSLTCQKQWLKTGDLVLFEGTDWNVSSLIPKSCNEKNQLFSLFFRKDTPNIFLIISQLMENTMLPVSGCHFGLDYAELLGSSLLDFQPATVLDMKLLNGSSILILGKLKEKCFLCEICLADVPLTFFEHQQKNSYLDAISHLPFIPLNSCLWLHEFEKDFLPSTLEYALSENSDYGVLISRESSRYRLFSF
The following text describes a protein:
Function:
Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNSHNITNESLALALMLVVVAILISHKEKLALEKDILWSVGRAIIQLIIVGYVLKYIFSVDDASLTLLMVLFICFNAAWNAQKRSKYIAKAFISSFIAITVGAGITLAVLILSGSIEFIPMQVIPIAGMIAGNAMVAVGLCYNNLGQRVISEQQQIQEKLSLGATPKQASAILIRDSIRAALIPTVDSAKTVGLVSLPGMMSGLIFAGIDPVKAIKYQIMVTFMLLSTASLSTIIACYLTYRKFYNSRHQLVVTQLKKK
The following text describes a protein:
Function:
Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.
Sequence:
MGSFRLTLSLHKEPDNKPVFCKVDGQRFAQPRTVKFLADSKYRVDVNIRPAKTVRGIAVMEKSLEVTDNSSKLEDENASSYSAQFQLDNLQPSKKGQRESVSLHVKVNTFTTTLQIKIYKANSTQHCDWGTTVHSIEYECHTDQQNNSIKIVKDTFR
The following text describes a protein:
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.
Sequence:
MAAFMAQKQQTLSQADLSKKGSIDEPIVNLVDYINGLDAFFTTSSCSGRISVFTELKASLESGYKNSGIVIGRKSRYMMAVRSTHSLEVPLICNGNLLVSKEYIQYVVDMANKKMEDNKDRIQRFYTKLKEAIQAEKKKREPNADKRRGSRRTPHLESEKTSSVQDVLSNDDSEDIEDCLAGFYGDLDDK
The following text describes a protein:
Function:
Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.
Subcellular Localization:
Nucleus.
Sequence:
MGGTKKKATVPIKKESKYKIPSHFDCPFCDAKKSIAVRLKRSDGLASVHCRVCRVGENRHYNFSPLEKPVDVFFRFREELMEKDHELLRAHNVETGAMAARTGLAQLAPKNRQQATLEEDMASAEPSDYDNFLSTVENISRSALLASDIHVDSEYDEPLF
The following text describes a protein:
Function:
Substrate-recognition component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations. Required for the adaptation to osmotic or heat stress. Required for the regulation of protein levels of the adapter protein ART2, a component of the ART-Rsp5 ubiquitin ligase pathway, part of the plasma membrane quality control. Specific for substrates with an N-terminal Pro (Pro/N-degron), including ART2. Has high affinity for the N-terminal sequence Pro-Tyr-Ile-Thr, and also recognizes nonproline residues such as Met-Tyr-Ile-Thr-Val or Val-Cys-Phe-His.
Sequence:
MTSLNIMGRKFILERAKRNDNIEEIYTSAYVSLPSSTDTRLPHFKAKEEDCDVYEEGTNLVGKNAKYTYRSLGRHLDFLRPGLRFGGSQSSKYTYYTVEVKIDTVNLPLYKDSRSLDPHVTGTFTIKNLTPVLDKVVTLFEGYVINYNQFPLCSLHWPAEETLDPYMAQRESDCSHWKRFGHFGSDNWSLTERNFGQYNHESAEFMNQRYIYLKWKERFLLDDEEQENLMLDDNHHLEGASFEGFYYVCLDQLTGSVEGYYYHPACELFQKLELVPTNCDALNTYSSGFEIA
The following text describes a protein:
Function:
Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile.
Subcellular Localization:
Secreted.
Sequence:
MRLPLLVSAGVLLVALLPCPPCRALLSRGPVPGARQAPQHPQPLDFFQPPPQSEQPQQPQARPVLLRMGEEYFLRLGNLNKSPAAPLSPASSLLAGGSGSRPSPEQATANFFRVLLQQLLLPRRSLDSPAALAERGARNALGGHQEAPERERRSEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MEAFERLHATSWEEAKEFVDTGYVSMSQEMNAVTQAVEMEVEQGFDIIEILTESSKGKDDKIKLLQEQKELNMDDPSFSPEKYLALMHNDTSFNRLINGPLRLETKIHHKNKEIMHLVESHFDQFINCKDTLDKMQVIINSAKAEAVKNGVYLNVVIKMQEKYNELLNSLSSIKQLTDLKNRVDQSRDAISVIERARSVFSLPAQLRSAAANRDDDRFVNVFNRAQGLSKETEIGIYQDVLQDCNITAQKFVDELFCSISKIDLTRNQYDRCLTTLFEMKQFPVIILKDNPVIFLLRSHRETLKKEYENGYKLMTEKKKESQHEKFLVQSINILQTNSKYGTNTRGMSTTTRSLTTINGGNNANKTIGFSKKYQTTHKFCSKMIEHISKLIGIMQFSSNKKKKETEEDSSQLRKTTVLFEDGTVVSVSYSKNTTGTMFLDLALTTYKLTHPDLPFDSEFELCSFIGKTTEKDKAVLEKALSEAIVLGENDMPFELETRWATASKEISHSFYARAKKGVVEKESTSDRSTYVVKIIQDFCDSMTKIFDYQEQYEDIEEFSNSNNLIDKACLEDIESVLTAFTAQQISNKFSDPLKKTHAELVTSFIERITSQTRQRIINLKNSDEIYINPGNGILIAFQKLYTEDFKMLKEIIQATENPDEQVIKYFSIAVEALKELFNTASKECNEALIAQKGRENETFDDSNIEMNEYRQLTKQRKLLSLTENAQNAFSGQVLWDLYNFSSTKKEVVGENSRVKDILKGFEEVSANILKYYINDRSGYFNDLMNRIDAKWYEIWIGEDIDYKVVDEYALNLITELIIIKQDLHIYAMSKESQCMSQIVLNLLKAFEEVTKKSTNEVIEKQTGEKESTIVCLRWLMGAEFIVESCKPLIQKDNETPQQIEEVLLNMKNMIGVESENTKNQRATAVLNTMNKFEALICSFKLSAAVNEEKMGKITRVRDQQRNISYLDVPMEKN
The following text describes a protein:
Function:
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPSFRDDHIIVIQTGSLYHRATFGLAESLEPPTIRVRTRVGKNDNGEYVFTNKEDINMEDPNVKTDETKVETSESTSEQPSNSNVTEEKNMGSSFHSECKVDDFTPLPNEIQPIQRGRVVDWEALKAFWKHLYSLLLKDPNDTTFRYPVCLVIPTYWSLYDRELATQFFFEECQVPGFTIAYEPLMGLYAIGILHGLVIDIGYEKTDITPILDGQIIFTATQQLPLGGRYMTQHLQNLLRESLPTLKSSGQYVSKEDITELFAEQVKCSEIAQVVRDEQDTAKDPVKALTSTNNVEEEDPAEDIGKIIASGQTRAYLAQKEREKNGESEKDEKPDNTDVEFQTIAIEPLGDCIVGRERFKICEPIFHRPSNETVSLPEAIYITIKNYAANYKRRNDLWENIIVLGCGSRIRGFRECLIQQLQFKYQLSGSLEPYYAAQGTDSILGMTTMPPTPYPALINPCKILPDYFPSWKPDAGTNAMFEELAFLGGSIVAKTSFNESVSSHYVTLEEYAQHGPTAIHTKQ