lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase; Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
Subcellular Localization:
Cytoplasm.
Sequence:
ENQQGDGVVCPSVKWLREQLLIKIKKWAESPACKNTKGSLRLIPMEKYTMLYQKMKEKHGERLVKSWPESTDPQKFVYEDIAIATYLLILWENERAEKNLLKKQSFVDLGCGNGLLVHLLTAEGHAGEGIDVRKRNIWDFFGPETRLKEQALDPTASGLFPEVDWLIGNHSDELTPWLPVIAARSSYNTRYFVLPCCLYDFNCKFVRRNNISQYRDYLNYIQEVGTACGFYVEEDVLRIPSTKRTCQVGKCRAYSEEEHPIMEVRIKDMIRTTMSTDLNSLGKESLTSCNNEGDSKKGISPDFVPRSSEILSRNCSQLQKAVREFMVSKVAEALLSAPRLIEKVNSCDGITSTGTPIQDWNPGGRLTLSEIVKIFDKETLQRLKSECGGIQTLLRNHRYVFKVVSGTVELRDWRVEVPGPKMTGRDPAYLQRRYDALYKTTTCWFHSYHPDGCCSKRCPYAHGEDELRDRPSAQYLKAV
The following text describes a protein:
Function:
Putative aquaporin. Could form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
MAGLNVSLSFFFATFTLCEAARRASKALLPVGAYEVFAREAMRTLVELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEESLPGTLLKLAAQGLGMQAACTLTRLCWAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHLRHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPLTGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPAKGSSVREPGRSGVEGPHSS
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRNLYRVSHSRFDLSENALRSVRSGFAIDQNTDHKFYFVQDSGVYCCPLFVDREHPFCEPLLSQSDGYENIIALEHLALSDELCCASSSGNVWSCKLETGVVEEVTHCKHGIRAMQWSPDQELVVFVDGELNVVTMIGSEFEPINEVQLKDDTFGDRQFMSVGWGKKETQFHGSEGKAAAKKGTTPSEPSTAETERQLDATVNISWRADGEYFAVGYLAPFGQRAFKVFNKEGALQYTSEKCHGLEGSLAWRPSGNWIAIPQELKDRYVVALFEKNGLRHREIPLTLNPRAGQSVQSLHWSADSDVLAVHWVDGEQGTTGVLLYVIGNYHWYLKQSLTYPPGTALTGLQWDQRHTAGKTLHLFSSDPGVYECIRFDFRVDRSVGLSEEDQTMVAVIDGKRLLLTGFRQAVIPPPMCGFTLEQEHPINATGFIRTAGRCEALGQDISSNAFFTVDCRGEIILYDAVFTKTAGRSILSGVTVLLKISPEQLKMFNEDFPQQHHCGLHYLWLNADNFVMDHSQLRCGVYTIAMHNDVPGLKKVWHMEMENREEIGCIESSGADSILVELLSGHVMEVKGLTGQQDGALETSSRNHSVLPVFCEQLFVDRNRPERTVYALAQNRRHLYRDGSLLASDITSALLTDSYLLCTTISELKFIALGAAVVAPGRDPIIGERRVERGSKLVAVVARASRTIFQLPRGNLEAINPRVLSLCLIAKHLDALEYYEAFDIMRKERINLNLLVDHDPARFLQHLASHFLRQITNVNWLNLFISDLANQDACKMYESNYLDRGTGGGSLPDGYTIAEKVRFCCDRLLAAMDSEPTVLTLPKITCHVKQGQLENALALIWTLKQQQQSPEAAEEALRYLLYLVEVNVLYDVALGMYDFGLVLFVATKSQKDPKEYLPFLNELKRMEENYRKYRIDCHLKRYDRALEHIARYETDEDRFREALELITTHQLYGVALRCYRDSANQDHYRRVCAVYGDYLRKGSKHANASLMYERAGDLQQAISSARHALDWRRVVRLSTGSSMAVEAVLRSLVPGLLEAGEYDAAATIAHDHLNDARLAIECLVKDHRYERALLLATEPELHETVRSSVGEYLTTLIETLGSEKEQFLRQKDRLATVRDDRIRKQSAAAAAGDLDDLDGDCGDCDLFSDSSTLASSRHTGTSGRSGKSHRSSKNRRKHERKLLNLKEGNPFEDIALIDALHSLVVRVCGVERQRHVRSICQVAMELCYDDEAHQLQQEYGALFQLIRYSLDAIWVPEMIVPGMPPTIGSGGDTAAIGDVPATILTPADLVKAQDSQRYSLIKPHQRYKPEVQSIAWQWDILK
The following text describes a protein:
Function:
AMPK may be responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase.
Sequence:
MWYPGDEDEEFTSIIENIEKKETQEIKIKTEKLRQASLNQLPIEQSEGVGGGELSEYNNNTTNNNTPTNTTTTTNTNTTTMNNSNNNNERILSTSNGFDIRLPPNSIEQPSPSFISSSQDGVLTVDPLAVDGEKGNKESQSPPNGDNQILNNNNMFFKDITSLPSTDNKSSTNTNNNNNENPLKQTISSSPSKSTTTTTTSTSTTTTPSLSSLSSNNNNNSNSNNNYINHSSISTVSEGLENLNLKSGIKKIDSETEKYIEEGKQVFVNFLKGHTCYDVIPISGKVVVLDTKLAVKSAFYALEENGIKSAPLWNSEQHDFTGMITVSDFIDILLYYYKKPKSNNIFQDMGIHRIETFWREISVERPSSLISTEPETNLYDAASLLLCYKIHRLPVVDKKDTNSILHILTHSRILAFMMKSFPQLPEKLLSIPIGSLGIGTFATVVTVMTHTPLVEVLELLSEKKISAVPIIDSETSKIVDVYSKSDVTLMSKQGILSPSDLNLPVHQVLSTFTKLWQRPEQIYTCTRFDKLGDVIERCIKKRVHRLVCIDSSKKVEGILSLSDILNYLLNDVKSINH
The following text describes a protein:
Function:
Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MDFSGGAGGATLSEMYQSARRLLLSARDGVARVERLASAPASSSYSASAPLVGAPDPAGAEAVRREVAQIQGLCAQMDRLWRSIPAKGQRDLWKRKVEQLSEEVESLKETLDKHSLRQRKRILEAKERAELFERANGESSHVLQIFDDEAQAMQSARSSSRMLDEAFETGVAILHKYSDQRDRLKSAQRKALDVLNTVGLSNSVLKLIEKRHRVDKRIAYGGMIITVVLMVAFWRWTH
The following text describes a protein:
Function:
May participate in the control of processing of mutational intermediates appearing during error-prone bypass of DNA damage.
Sequence:
MSYSVNTFTDYVLLFGSSSLVGKGILENLLDINLYIKNVSDLQGKLDSLSEIKGNVVLNKHVFCVNRRCINEEKSFMKTIDYINMRSVTWQGGRYYLRSRKEKDTEKVPSSPNTFCYDNFEEGFIKNTPEERGKDGYSFVYNQKQFSYTLHYACGKEKGIEIICNFTVTQLIIPRSETWPKLLPRIFSGTQKLEKFDIDNKNYVPGRSLPSLCDISTMVCSLGSTSARVRRTQVPSSFADYYLPFNLAQEFTNTTNKRLVVTTAFNNDFLSKTFEYFRIKAKLENDLDEALPNKLKELVILRPGPMCGQHGNPINVELGKENSTFLEKIFYYPHYLLVYKKKYISEARRIGLRTKLSEIIASSIYRMPGSALLGYAVPVSKVSYVASLMAIERKSKEAGPKLEVISSYQIDMIV
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
Sequence:
MPIVDKLKEALKPGRRDSADDGELGRLLASSAKKVLLQKLEFEPASKSFSYQLESLKSKYVLLNPRPEGAGCPKSGGEPPAIRQGGELASDGDGDGVPAPQKVLFPGERLSLRWGRVYRVGAGLHNLGNTCFLNSTVQCLTYTPPLANYLLSREHTRGCHQGSFCMLCVMQNHIVQAFANSGNAIKPVSFIRDLRKIARHFRFGNQEDAHEFLRYTIDAMQKACLSGCAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQAANIVRALELFVKPDVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKEVGYPEFLNIRPYMSQSNGEPVLYGLYAVLVHSGYSCHAGHYYCYVKASSGQWYQMNDSLVHASNIKVVLNQQAYVLFYLRIPGSKKSPQGSISRTASSLPGCPGAALDHVKKSVSNGPASSPPAGKRPDPAMMKKPQTPEELGVPVARNGSVSGLKPQNGYAPPKPPVGSPSPKLSKTPTHAPTLLEEPGKKVKKPAPPPPLSPPPRPSQGPRGAGEPGGSRGEGRGPGPWGGKASLSPSPRPLAPGTANGLGPQAGDGGSAAERRGSGGSSPERSAGSGPARNPQAPQGGSTHLCESQGTPSRGPPAQEDARLAKAKCPILSGAAPEPANTMSPPPAKKLALSAKKASTLRRAASSDLRPPPLSPSSDLTHPRKPAHPAAASTWPRSTIRAVSPAPRPSSHLKPPLGPRPPSLPSSPQPLRTSDPQSCSSASAPLPQVNGGFQAPPHQPPEASEPPRAPVRRSGSPAWLRPRTRAARPARPRRPHPGSGEGGRGSTRGTWPPPPRPRRRGCYRDSRGVPSAGRRAGRSRQRTDGRKRADSSKESAGAWGAAVGPGDV
The following text describes a protein:
Function:
Transaminase that degrades gamma-amino butyric acid (GABA) and uses pyruvate or glyoxylate as amino-group acceptor. Cannot use beta-alanine, ornithine, acetylornithine, serine, glycine, asparagine, glutamine, glutamate, valine, leucine, isoleucine, methionine, phenylalanine, histidine, lysine, arginine, aspartate, threonine, tyrosine, tryptophan, proline, or cysteine as amino donors.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAKITSLIGSGIVAATNQVGPHVKHIPAVGNLQKQIVSDQIQVRWSSTETSLKNDISATDVRGYKGHDMLAPFTAGWHSTDLEPLVIQKSEGSYVYDVNGKKYLDALAGLWCTSLGGNEPRLVAAATKQLNELAFYHSFWNRSTKPSLDLAKELLDLFTANKMAKAFFTNSGSEANDTQVKLVWYYNNALGRPDKKKFIARTKSYHGSTLISASLSGLPALHQQFDLPAPFVLHTDCPHFWRFHQPGETEEEFSTRLANNLENLILKEGPETIAAFIAEPVMGAGGVIPPPATYFEKVQAILKKYDILFIADEVICGFGRLGTMFGCEKYNIKPDLVSVAKALSSGYMPIGAVLVSPEVSDVIYSQSNKLGTFSHGFTYSGHPVSCAVALETLKIYKERNIIEQVNRISPKFQEGLKAFSDSPIIGEIRGTGLLHGTEFTDNKSPNDPFPPEWGIGAYFGARCEKHGVLVRVAGDNIMMSPPYILSLEEIDELIIKYGKALKDTENRVEELKSQKKIKSS
The following text describes a protein:
Function:
Kinesin-like motor protein that promotes synapsis and is required for proper crossover distribution in meiosis. Plays a role in the nuclear division cycles during megagametogenesis.
Sequence:
MSNVTVCARFRPRSSKEMRDPSRDGVCARPIDAETFVFQDDKEDEFTFSLDRVFYEDSTQAAVYEFLALPIMRDAVNGINGTIITYGQTGAGKTYSMEGPGIQDCDEHNKGLLPRVVHGMFEQISSSNDIARYTVKLSMVEIYMEKVRDLLDLSKANIQIKENKTQGILLSGVTEVPVSDSVEALQHLCTGLANRAVGETQMNMSSSRSHCAYLFTIQQDSVKDKRVKTGKLILVDLAGSEKADKTGAEGRVLEEAKTINKSLSALGNVINALTSGPSSKGNHIPYRDSKLTRILQDALGGNSRMALLCCCSPSTLNASETLSTLRFGMRAKHIKASPRASEVKSAKAQEEPSSVTKDEKCGRILEKMKERMSNEDIKMLEDVFIQEGIIFSLDSMAEVETVYEDIVSKTIQSLQQAVDELQQKVKKLEAENIGIQEQALRNHEPGSVGKMSRFISSWYASFFTS
The following text describes a protein:
Function:
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
Subcellular Localization:
Cytoplasm.
Sequence:
MERIILRDPTLIPPFAEPARELRILNKPLWLLQRDLLKVYGKKATEIDHLAEVADIPAHDERLIYRDNLFFNAELINTFIQEARARGTPAQIAFKATNPATGQKGDPSIERHATQLSRHIRREGDYYVADLYYLPAGSNDLSQAQPLVIDTLSHEMGYYRIPSYMAHKGDLTYQIPIRAFVSIESWLHVLMANVLMGVFSWAAALDVRMSKARLHNILRWTAEDWRLFPGKIAFALKAFWEKINPLEEQWRNHFLASRALVKVGKRCSIDPTAIIHGPTVIGDDVYIGPGVVIANSYIGNNVNIMQGSQIMLSVVSDRCFLPFNAGLFMTTLMENSMVAQNSTLQLCVVGRNTFIGANNVFTDFNLQGEPIKVIHEGVPVEVNMPVLGSAVGHNVKLGSGFVIYPGRMIESNAVIIFDNEQNLIRKTVAGHDLNDIDEATGEPRRIIYHWPNVYYDPARPDVNSPSEGDSPVRMSSLRSNQSAGNGRLPDHISASQRL
The following text describes a protein:
Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MPGERRRFAQATKSVGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAPVEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF
The following text describes a protein:
Function:
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MMATSGIANRVKTWLISTWHVKVPDPWLEACINWIQEENGSSLLQAEINKQVFEQWLLTDLRDLEFPVLPANITDSLKCELNGFHAVQMDSLVDISLPAYSQLQKLKGKDSTNEQVTCTTQQSQKPWEAKPTRMLMLQLTDGTQHIQAMEYRPIQALNANLSPGTKMVLQGTIVCRLGVLLLKPENVKVLGGEVEALVAEYTQTKVLSRLIGVEDNTVAQHSNVQEHAAGVAAGELGQALGPSDEDLLASLEENEEFSINNGVPSESGYYSRNENSSISSSTQHQTQDSIVRCWVDDDILEFSINNGVPSESGYYSRNENSSISSSTQHQTQDSIVRQTSFPMLDQTVVHVNVANNHAIEEQFDIDDELFLEEEIQRELEEMSMSQAEVTHGSTDLPTTLSATSHASSASCTSDQNNIDIPPYTYLSTILASKSRSITCVKLKSFIVTLNGNLSHSCGLWNIKAKISDGTGYLNVEFSDDVLTELIGFTVPEMKTLKKDPSQQSTLMEGLQKCQRMLTDFCGVMTVSYNPAKEEAVVLSLQDVTEEIMQSLQKLLRS
The following text describes a protein:
Function:
Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
Subcellular Localization:
Nucleus.
Sequence:
MESKHYLYVDNPFKGNHLRKIEVEQECKVRVLSRFFHKVEECKVEHIPQRVVSRSTKSIEDLDQYRYQSEKVSSLRECVNKREHEGTDSYPLPPKIPKDSRKRPKVEKPRKSKRKTKPFLKADRCREAYKRKTLDNNWVPPRSTPPLVEKPLLQEDHFHDPWRVIVICMLLNRTKGQQAEKVLANFFKLCPNAETCMQVPKVEIQEVIKTLGLQVKRSESLQRLSREYLAGTWTYVTELHSVGKYAADAYAIFCTGKWDEVVPDDHKLNKYWNFLHSIKDTL
The following text describes a protein:
Function:
Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
Sequence:
MRMRLMLLGGGNALGQALIRLGAEEDIGFLAPRPPEQGWDAASLTTLLDETRPDAVINLAFYHDWFQAEQVEAERLGAQERAVERLAELCQHYEILLVQPSSYRVFDGARATAYSEKDETLPLGLRGQALWRMEQSVRAACPRHVLIRFGWLLDESPNGLLGRFLSRAEQPQPLFLADDRRGNPTPVDDAARVVLSVLKQLDCQAPLWGTYHYGGLEATTTLALGQVILNEARTYRSNLIQEPSAEAHAARPDALDEPQHAVMVCKKILHTFGIKPRAWRAGLPALLDRYYRHV
The following text describes a protein:
Function:
Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Silenced copy of ALPHA1 at HML.
Miscellaneous:
MISCELLANEOUS: There are three genetic loci for mating type genes in S.cerevisiae. MAT is the expression locus that determines the mating type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and HMR (containing HMRA1 and HMRA2) represent silenced repositories of mating type information. The mating type is determined by the MAT locus, which contains either a copy of HML or of HMR. Diploid cells are usually heterozygous for the MAT locus.
Subcellular Localization:
Nucleus.
Sequence:
MFTSKPAFKIKNKASKSYRNTAVSKKLKEKRLAEHVRPSCFNIIRPLKKDIQIPVPSSRFLNKIQIHRIASGSQNTQFRQFNKTSIKSSKKYLNSFMAFRAYYSQFGSGVKQNVLSSLLAEEWHADKMQHGIWDYFAQQYNFINPGFGFVEWLTNNYAEVRGDGYWEDVFVHLAL
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MMLDGVISFAEPIVAKWNVRTSPHHDEITYLFSQNSGDEVSSFLDAVSQLHRSMHLSVSVVSTVPSVRRELILAQTLMEMAMKRLQMEFYQILRTHRAITTSHDNSDEIDGYRFSDTAMRNMKTIVEFMISCGYTMECLNIYQLERKSIVDEVVDRVVFRNITLSTIQKLDWESMKTLIENWLAASKIEIKKLFSDERILCEYIFGASSLNQLKESCFANITRDFAVRFFQFPELVTSIMIAKKNRKTKNKIPLSEKMFHILDLYTANYDLTNDIQIIFSYSSTAAVRKQTKRSLKTLGESARTLLSEFEYTVEKDAANGSVRGGGVHPLSRRTMNFLVSISEYDTTLSNIFVDQPLPTSTPPNREPTVSGRLSWLLRVLQCKINGKATAYSDVSLLYIFLANNLKYVITKVKESNLYQLLGRDWVVEQEKTLSSFLKNYETATWGRVSLALAQENIGEFNSEFRHAWQVQLKWVAVEEGSFRDEIITMVKKKVLVPYQDLYRKRTNQEGTANDMLRFEYINCIFRGDSTPSESDQDCSSRSGSGSYSSNNFIGSRFFSK
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase required for embryo development.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSSYSSDSTAARDQHAPLLRPRHDGSFSSSSSSARPTALAVLLGRITGHRAPSMLVRETAARALEERRIDWGYSKPVVAADILWNAALVLASAVMLVGTVEERPNEPIRVWICVYGLQCLFHVVLVWSEYWRRNSTRRARDLESYDHEDYNIEYDYEQDSDDNSTTYSFVKRCESINTVISFIWWIIGFYWVVEGGDKLLGEAPNLYWLSVIFLAIDVFFAVFCVVLACLVGIALCCCLPCIIALLYAVAGTEGVSEAELGVLPLYKFKAFHSNEKNITGPGKMVPIPINGLCLATERTLLAEDADCCICLSSYEDGAELHALPCNHHFHSTCIVKWLKMRATCPLCKYNILKGTTDQS
The following text describes a protein:
Function:
Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Preautophagosomal structure membrane; Multi-pass membrane protein.
Sequence:
MGNRRTSPASMIGEFELKLSDGICNARRSGLVNLEIIGVENEFSTKDKSRFNLYTGSLDDRSDAVAAFVSLARDNEWYGKLIIEEGGDNLLLKLVKEGKPEGQENVASAIGLLRRDPESVEHMIHVVTTLRAIRKIFIDPDSRLRNWRRGDPCVSNWTGVLCFSKTLDNGYLHIRELKLLNLNLSGTLSPEIRRLSYMQILLLNGNNLTGSLPEETGNLPNLNRIQIDQNHKSGPIPVSFSKLNNTKHFIPSSYGNMLQLAKLSFRNCNLQGSILDLSRTPHLTYIDLSDNNLNGSIQPVNLSHNITTVSVLHTICKKEPSPGSESPLGLLNGESLKVESIADLDLFFKRLYSYYCEKGLCCIIIKWLVELLSLAFTICFVSF
The following text describes a protein:
Function:
Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase; Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MEEVPLVRSCTQVPLENFWKAVLVYHNRPHVINRKLAAIVPLIFCKITLNCPGVKRLRDVFTWESLIYEVRKLPDLSQITPQFIKNITEIYDKKATVEETALETLDNCYEGTFLSIRQLLSRKNNEKCLEIAIFDKDTQTVTFLAAQEQTSPIIAPRFPYHIHLTKSGHLTIILNEFEIAETASAEWLADKLFPKLMKWSENDISDDSVIKSLSLVAPSDYCTLYSELKVKYGRDLVEKWPQKAKTDPQKYVFEDIAIAAYLISLWRHLKTENINFVDCGCGNGLLVYILNKEGFKGCGFDIRSRQVWEIYGGEADLRTGAVTPESIYPDATWLIGNHSDELTPWIPIIALNSSPKTNFFVLPCCPYDLSGRKYVRINAALSQYGDYLDYVKNISTMCGFTTSVDKLRIPSTKRTCLVGNKNEPELEETRQKMKEFVEKNTRDFVPRAAVEKVRNCTRLDPDLKKKIINLIVDELLQTPCDSEISDWKTGGTMSLEELSQKISSEDRKALKNECGGLQTLIKNHRYIFELRKTWVTLRAPQTLKQTDKYKDKPCWFHENYPYGCLHSAEICCYKHVEKN
The following text describes a protein:
Function:
Negatively regulates early sporulation-specific genes. Seems to exert its function by positively regulating the Ras/cAMP pathway. Required for growth under alkaline conditions. Acts synergetically with PMD1.
Miscellaneous:
MISCELLANEOUS: Present with 396 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MPLLQPSTCFCYPLKLPPLPLTSDSNEFDECARKRLTLDYRTGSAVTLTRSNIFVHGGLTIPLNLPVVNSMQLQKELILFFAKEKNNGSSFRNLNEWISKETFFLDLMSRTWYRVKTSFDQRTEELLKAESSSAKADNDTNEIRTDIKKGKSLESPLKERLFHSLCYLDGCLYIFGGLTVSPQSGYELIATNELWKLDLNTKKWSLLSDDPQIARRFNHTMHVKNENNDNRDTKLIIVGGLNNMDQPVKKIDIYNISQNCWQSETIPKQPMEITTNVNGIPLALSKDQNFSILVENNEANVPALAFYMRSDQIDEYLGKDSSKIKENSPIVALPLLSESQGIRMPSNPALPKKLLNVPYELLAPTGDYFGFNIIIGGFHPNYQSSNFHCFIYDINSGKWSRVATACPDCDINKHRFWRVFVWKSHHQTILLGTKTDDYYSPSVQRFDHLSTFGLPLVNIFNKTIQLPHHKISASSLPIPIENFAKHKDTPLKKVSFTSSATSQFENYIRYIAPPLEMSSIQSVFPPYAMVLGKDALEIYGKPLSDFEFITSEGDSIGIPCYLLRKRWGRYFDMLLSQSYTKVCADYETTDTQSTLIKFSPHSSRNSSKAVRQEGRLSSSGSLDNYFEKNFPIFARTSVSEAQNTQPQVANADAKAPNTPSTSDEPSSSSSSDLYSTPHYQRNNDEEDDEDPVSPKPVSKSNSIYRPIRKTESSSTTSSSNGMIFRVPFKEKAAVTSNTEALLESNLSLQELSRRRSSLMSIPSGELLRSSISEAEHQRRASHPLTSSPLFEDSGTPCGKQLQQLQQHTIQNPHNHLSPRRFSRSARSSISYVSSSSDRRGNSISSRSTSDSFGTPPVLGVLNVPLPPQTREPNEPPPPCPAMSTGSNTRRSNTLTDYMHSNKASPFSSRRSSHIGRRSSTPETENAFSATPRASLDGQMLGKSLKEGSTSQYTQPRMNSFPKANETIQTPTSSNNEWSRQSVTSNTDSFDSLQSNFALELEPLLTPRSLYMPWPTSTVRAFAEFFYTGQVNSKWLLAPVALDLLVMAKIYEIPLLYKLILEVLYSILAKKEESLSLICTSLMETFRTKTLNSYKGDEEKTNTYLTSNDNYQELLKLKVSLENIDNGYYDPDLLRKQSRAQSSSTQESSGSANGEKTATGAGSLETSSTNVPTVFAGGPRDSHNSVGSIGFPNSMNIQGSRRSTSGFSPRVKMKSSLSKEIDPKTFYEEYEPKEGKSFDDNDDQQTNIGSFNLHLFDMNYGSISSSSTNSISSSDLEEKEEQEQLQDLLEIEREDSAEILDARFRNKEDDKVTKDISNDKKRNYLPHEKNNLKAKEGKETRDVREEEEEFDFGLGMLSLNKIKREAKHVDKVDDSVDPLFKSSAFPQSPIRAYGSTTRTSSASGKPFRDNRSFNAFSVLTLENMASANALPPVDYVIKSIYRTTVLVNDIRLMVRCMDCIELSKNLRALKKKTMEDISKLKGISKPSP
The following text describes a protein:
Function:
Mediates the conversion of cyclohexane-1-carbonyl-CoA (ChCoA) into cyclohex-1-ene-1-carbonyl-CoA in biosynthesis of cyclohexane-1-carboxylate, a by-product produced during fermentation of benzoate and crotonate to acetate.
Sequence:
MYINTETEDLKTAIDAIRKAVKDRIAPLAAEVDDSGVIKPEIYDLLWDLGLMTVTYPPEYGGSETNPGTLLCIGCEEIAKACASTALLLIIQAVGSFPLMHGGRKELLDRIAPRIVNNRELAGYLVSEPGAGSDVKAIRTKAVKDGNDWVINGTKCWATNGPIASFYSCLCRTKDDKGVQGYSFFLVERNTPGLSVGKIEHKMGMRGSQTSEVILEDVRVPAENLLGELNNGFKLAMKDFDMSRPAIAAQALGISEGAFAQMETYSRERYTFGKPLCEHGMITQIIADSAALIEAGRGLIYQAADLYDKGKKNTKLASMAKFFMGDAAVKITTDAIQVFGGYGYTHDYPVERMFRDAKLTQIFEGANQIQRIVVAREIRDEQSK
The following text describes a protein:
Function:
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTAQTQELDVQPTPLALLLLGREADPRSERGVECPGDLPSPSDPDLVARARAAKEKLGDKVFVLGHHYQRDEVIQFADVTGDSFKLARDAAARPEAEYIVFCGVHFMAESADILTSNDQKVVLPDLAAGCSMADMATAEQVAECWDVLTEAGIAEQVVPVSYMNSSADIKAFTGKHGGTICTSSNAERALNWAFEQGEKVLFLPDQHLGRNTAVRDLGMSLEDCVVYNPHRPNGGLTAKELRDANMILWRGHCSVHGRFSLDSVNDVRERIPGVNVLVHPECKHEVVAAADYVGSTEYIIKALEAAPAGSKWAIGTELNLVRRLANRFAAEDKEIVFLDKTVCFCSTMNRIDLPHLVWTLESLAEGTLVNRIEVDQETEAFAKLALERMLALP
The following text describes a protein:
Function:
Catalyzes the oxidation of L-gulono-1,4-lactone to ascorbic acid. L-gulono-1,4-lactone is oxidized to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate (By similarity).
Subcellular Localization:
Vacuole.
Sequence:
MRYSHTLQQFSILSFFVTIWTVQSVPPQPPIRCDQTGCTVSNAYGTWPDRKTCHAANVTYPTTEEDLRKAVAYAAEHNLKVKTVTKFSHTIPKLACPSGSDALLISTSKYNSVIEIEPELLTVTADSGVSLRELIEKVEGAGFSIGTSPYWEGVSIGGLISTGSHGSSWSGRGGSVHDHVVGISLVVPANQSEGFAKVVRLEEGRDDTLLNAVKVSLGVLGVISKVKLSIEKAFKRSVTYNFTSDVALEDIFMEHGKKYEFGDITWYPSRKTAVYRYDIRAPVNVSGNGVNDFLGFQSNPILISKGVRALEKGFESSKNENGKCTTADTTLAYKKLIGNGLKNSGLIFTGYPVIGRQGKIQTSGSCLYSSSIRIDVACAWDPRYNGLFFYETTAIFPVSRFRDFLLDVKKLRDMKPERLCGIDIYNGIFIRFIKGSKAYLGQTEDSVVIDFNYYRADDELTPRLNQDVMEEMEQMAFVKHGAKPHWGKNRKVGFFGVKQKIGPNFDKFLEVKNKLDPKKMFSSEWSDEILLGTEASKYDGCALEGNCVCSEERHCNPSKGYFCKEGLVYTQARVCRFSPAQVIVM
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MSTTTAAPLTRTLLSSNKLSPTLRQIGKNAPKSISKTSPSSSSKPAFVQKPWQTSAPPTPTSYFRITLTRSSIGLPKKSSRVLKFLGLHKRTASVYHPVSSDIAGQIMKVKELVTVEETKEKMSKRQERERRRPEAGFFVEREVQAELMV
The following text describes a protein:
Function:
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MRGRRGMGPPEPAVVAATVLLLLSRVEPACGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTTVELYVDGVSDICTKGGDINFVFTGFSVSGKVLSKGQPLGPAGVQVSLRNTGTDAKIQSTVTQPGGKFAFFKVLPGDYEILATHPTWPLKEASTTVRVTNSNANAAGPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNLSPVPGFQPQDESLEYLCHAVSKEDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGEGVPDAVVTLNSQIKVRTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIIATGFSVCGQISITRFPDTVKQMGKYKVVLASQDKDKSLVTVETDAQGSFCFKAKPGTYKVQVMVPEAETRAGLTLKPQTLLLAVTDRPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLHLSGKVNSMTFMFDNVLPGKYKISILHEDWCWKNKSLEVEVLEDDVSAVEFRQTGYMLRCSLSHAITLEFYQDGNGPENVGIYNLSKGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSVQELRREQQLAEIESRRQERERSGGEAGGEGRTKPPVQEMVDELQGPFFYDFSYWARSGEKITVTPSSKELLFYPPSMEATVSGESCPGKLIEIQGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVSSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGVFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTAYSCYGTVSSLNGEPEQGVAVEAVGQSDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKAEGNDHIERALPHHRVIVVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKSDNLDNPIQTVSLGQSLFFHFPPLLRDGQNYVVLLDSTLPRSQYDFVLPQVSFTAAGYHKHITLVFNPTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVRALGQTASDNSGPEDAKRQAKKQKTRRT
The following text describes a protein:
Function:
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
Sequence:
MSAKEKFASLSPAEFFKRNPELAGFPNPARALYQTVRELIENSLDATDVHGILPNIKITIDLIDESRQIYKVNVVDNGIGIPPQEVPNAFGRVLYSSKYVNRQTRGMYGLGVKAAVLYSQMHQDKPIEIETSPVNSKRLYTFKLKIDINKNEPIIVERGSVENNTGFHGTSVAISIPGDWPKAKSRIYEYIKRTYIITPYAEFIFKDPEGNVTYYPRLTNKIPKPPQEVKPHPYGVDREEIKIMINNLKRDYTIKEFLMSEFQSIGDTTADKILELVGLRPNKKVKNLTEEEITRLVETFKKYEDFRSPSADSLSVIGEDLIELGLKKIFNPDFTASITRKPKAYQGHPFIVEAGIAFGGSIPVGEEPIVLRYANKIPLIYDEKSDVIWKVVEELDWKRYGIESDQYQMVVMVHLCSTKIPYKSAGKESIAEVEDIEKEIKNALMEVARKLKLYLSEKRKEQEAKKKLLAYLKYVPEVSRSLAIFLASGNKELVPKYQGEIVEGLFKLISKKLDLINIEEYRKVYKVDSE