lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play a role in abiotic stress response.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGEEAAMATMESAYHDELAPAAAPAPAKGGGSKKKRKQQKREEKRKECRLVSYHELPDYMKENEFILDYYRSEWPILNALLSLFSWHNETINIWTHLLGFVLFFGLTVLHLGQYFPQVADLIGHLSWPISKVAENVSSNIGDVLSGAASFMQASPASSAGAMAAAWPVTAAAAATTRWPFFVFLAGAMFCLLSSAACHLLSCHSHRLNLFLIRLDYTGIAVMIVVSFFPPIYYIFQCEPRWQVVYLSAITAAGVATVYALMSPRLSAARYRAHRALLFVAMGLSGVVPAAHAVAVNWHEPRRNVTLAYEGAMAASYLAGTAFYLTRVPERWRPGMFDLCGHSHQIFHALVIAGALAHYAAAIVFIQARDEMGCPAP
The following text describes a protein:
Function:
DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MKIITYFCIWAVAWAIPVPQSKPLERHVEKSMNLHLLARSNVSVQDELNASGTIKESGVLVHEGDRGRQENTQDGHKGEGNGSKWAEVGGKSFSTYSTLANEEGNIEGWNGDTGKAETYGHDGIHGKEENITANGIQGQVSIIDNAGATNRSNTNGNTDKNTQNGDVGDAGHNEDVAVVQEDGPQVAGSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSDD
The following text describes a protein:
Function:
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MRRLFKGLFGKVDGQNQNLPKIRVGVCAMDKKARSKPMKEILERLTAWGEFEVVIFGDDVICEKPTEEWPHVECMLCWHSDGFPLKKAQEYILNRRPFLVNDVFMQDALLDRRRVYKMLVEKNIPVPTHIIVERDGLPEGVTDPPGFVEDEDYVELNGQRIYKPFVEKPISGEDHNIWVYYPHSMGGGVKYLFRKVDDKASKYDSEHNGCVRRDGSFIYEEFLPTGGTDVKVYTVGPRYAHAEARKSPVVDGKVLRSADGKEMRFPVLLSPQEKEIARMVCLAFGQKVCGFDLLRSEKGRSYVCDVNGWSFVKNSKKYYDDAAGILRSIILSALAPHRLNVQPHLPTHSSATNPDTGSAVVSDEEDDDDALVPGMDVSEVRHTAKRSQKEELRCVLAVVRHGDRTPKQKLKVVVTQEPLLALFHKYKDAKGKQAKLKSPLQLQELLDITRQLVKDFERRDDEKEGGVPPLGDEAKEAAQEVRGKLRIMQTVLESGGQFSGINRKVQIKPLRWGVAPPAASASDGVASPTAAAAPVAHAGPIAGAGGSMEMLTGLGSGIDVGSSSMATLHNSPSVGGAVNASSSAGQPVLEEGLLILKWGGVLTHAGRQQAEDLGKIYRMVMYPSGGNGLLRLHSTYRHDLKIYSSDEGRVQTSAAAFTKAMLDLEGASLTPILVSLVNKDASMLEAFGKGASDDIAEAKEALYQAMTWDPEKPGDKPLAVSKLSHTPMISPPLSPKVSRASSFAAKSAGGVAAAAAAEVSSLQTMSSVEAAATASVPPSVSPAAANPTVLPVLQRMIERLAGLKAAARERMAEQQKEAEREREREAVVATGAAAAAEKEQKEKEERAANPGPRPASSGGAAEPATEGAATAGADEADDEGPAGGEPEAKLPAAPVPAAAAPADAAAVDSAHPAHDHPASGKPPPHPSGAGGLARSSVAAHGAHRPSPLSKRSFEPAAAAAGSAHTHTLLRLGSPSAVAIIAGLPDTPLGLLRRLVELLRKLEDRLRQLVREDGVAGVRAGAKYSSLSMDPKERVHEDGQPCGGEKMLLMFDRWHKLLKSFHNEKKDRFDISKVPDIYDSAKYDAIHNGHLGLDVLEELYVVAKLLADVVIPCEYGLDSGGKLRIGSKIANELLGKLLVDLASMREESMATAFMEPGAGARGGAGTPGGTLGFNYDQLEGDVGRISLQDEAMVKHHSHGGLRAGPASAVSSSRGEQRDRSGPAPSTSGTGGGGTEGGAAADGAPGSAGNTTSGGGAGGGEMEPAETETIHRLCPTYASDINSPLRHVRTRIYFTSESHMHSLVNVLRWCHEGPEAADCCPPPITPPSGTGGNSSPDLRASAGGAAAAAVAAALATEGGASSPVAGAASGAAGEPAYGRQFDNSPLLSANACAQLDDTTELDYLTQVVFRMYENKTVPVESPERFRVEVLFSPGANYNPFDFTMPLHNNHVLPTIPRTALHKGDGITLAEMEEKLLPFSQTRKFNTCSYALQYSLRAPHLIHGGVNSRYGSTGALGHNGRSTASIAGNDSTGDLAATKGAGKEKAVDKEAKEKEAKEKETKEKSAEKEKEAKEKSVEKEKEANEA
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MDERFLNPPPTADQDDTNQPLDAIFGDRVRRFQEFLDRIDSNTGIDYRSIIKDMLIKSKFRLSVSIDEIREFDREFWLGLLNQPADYLPACERALRDTVLAIYDPQDPSFPHDSYDPNQQYYLSFKGAFGGHSLTPRSIDSSYLSKMVSIEGIVTRASLVRPKVIRSVHYAEKTGRFYAREYRDQTTSFDAIATPAIYPTEDMEGNKLTTEYGYSTYRDYQKISVQEMPETAPPGQLPRSVDVILDDDLVDLTKPGDRVQIVGVYRALGGAANNSSSFKTVILSNSVYLLHARSTGVASQEKLTDQDIRNINKLAKDRKIFDILSRSLAPSIYGFDYIKKAVLLMMMGGVEKNLDNGTHLRGDINILMVGDPSTAKSQVLRFVLNTASLAIATTGRGSSGVGLTAAVTTDKETGERRLEAGAMVLADRGIVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHTSLNARCSVIAAANPVFGQYDVHKDPHKNIALPDSLLSRFDLLFVVTDDVNPTRDRVISEHVLRMHRFVPPGLMEGEPIREKSAVTLAVGDDETNEQELLEQPMFEKFNTLLHAGIQNKKSNNILSIPFLKKYVQYAKQRVQPVLTKGASDYIVTTYSSLRNDLIGNNQRNTAPITARTLETLIRLATAHAKVRLSKTVDVKDAKVAEELLRYALFKEVAKKTKKRQKTTSIVDSEEEEEDESDAEMENSDNEIMPRESTRRTRATAQTQPPQQQQASPSLTPEPPLGHRDDGDDDGVGEELEQFHLSSSQQQQQQQYLQPLTERSSSNIVSSTATNAISIERLNIFKRILAQVSRSALFANDQAAANYHDVTRAINEQMEQEDIFSEQELSAGFEVMSSENKFYLESDKIWKI
The following text describes a protein:
Function:
Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions.
Miscellaneous:
MISCELLANEOUS: Encoded by the cryptic lambdoid prophage DLP12.
Sequence:
MDYVCSVVFICQSFDLIINRRVISFKKNSLFIVSDKIRRELPVCPSKLRIVDIDKKTCLSFFIDVNNELPGKFTLDKNGYIAEEEPPLSLVFSLFEGIKIADSHSLWLKERLCISLLAMFKKRESVNSFILTNINTFTCKITGIISFNIERQWHLKDIAELIYTSESLIKKRLRDEGTSFTEILRDTRMRYAKKLITSNSYSINVVAQKCGYNSTSYFICAFKDYYGVTPSHYFEKIIGVTDGINKTID
The following text describes a protein:
Function:
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
Sequence:
MKEVDYSLYLVTDSSMLPQGTTLDSQVTAALQNGATLVQLREKDADGCDFVEAALRVKRICAEFNVPLLINDRVDVALAVDADGVHVGQQDIPPPLVRKLVGPSKIVGWSVGRPEEVQQLAEWGQGCVDYIGVGMIFPTETKKNPRKVPMGISGAIEIMDALEECRATWCRTVLIGGLHADNIGRVLLQCASSNGKRAADGVAVVSEIMAASDARGATQRLRRLLDDGAYRFVVGKFTEDVDYRAPDDMETYVPMLLEASPLVHHVTNKVHQNFAANVTLAAGSSPIMSEVSSEFEDLSTAAHSALVLNTGSLVDLEVATAAVRAYNKARRPVVFDPVGFAASRTRLDYNGHLLNMGQYTCIKGNASEILALSSSEHRAMRGVDSEHDVDIDTLCNAARQVAYRYRTVVVLTGQNDIVVNGALDCSFNLGFGSAPPQDHLPAYIVSCDSIPLFSKVTATGCSLGSVIACFLGALPPDGSPFHAVLSAVLIYKSAGYFAAGRATGGASFQTELLDELDTLFEKGSHGQMAKIYPFGSWPVKVERVDIP
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
Subcellular Localization:
Cytoplasm.
Sequence:
MDTKPPRQRLIGLTGGIATGKSTVTDYLQQKYSVPILDADLYARQAVEPGSEILVAIARRYGPEILDQQGQLKRQALGEIVFNNAEEKQWLESQIHPFVGRCFRSALAQLKQEQTVLLSIPLLFEAQLTDWVTEIWVVTCGPQQQVERLIKRNGLTEAEALARITSQMPLAEKVALADVVLDNSGQIADLEPQIIKAWHHR
The following text describes a protein:
Function:
This IE protein is a multifunctional protein capable of migrating to the nucleus, binding to DNA, trans-activating other viral genes, and autoregulating its own synthesis. It is required for the switch from immediate-early to early mode of gene expression.
Subcellular Localization:
Host nucleus.
Sequence:
MVELGFPAYGPAIEKRVRPLYKALCDWRAAVTLAARRRFQQLRCNANMDDDGQPMFPPLPVPDWNNPSTDWRPSPPRSGPKKDFCGDLPAPLTSGPRLTTPSSGRMSELPHTTSSPRSSPRPRGPETSPSNEHIIISPPRNPPSNTTHRNVGHVSRSPSSSSSSSSSSSPSSSSLIVLSSPSSSRSPSPSPPRPRADSSSRPRRGRGSNRGGRSGPQSKGRKASPRTRKLEDEDYLPQETANRRGGGRPRGRPPKSGRAVQRNDIQVTSSSGLADTSPYDLCGSVWWEVPLPPPGRCWFGGLGGHRQALTDSPEIVEAIHRFNTSHGPVPVYVEEMKDYAKQYDALVNSLFHKSMKVNPLNWMHHGKLSPADAALNHIYVQKFQSSYDSPGAAVTGTVNRCIPHIAGAMKERKLLWAFPHIAASIAMTRRYCKDQKTFLFRSLKKAYASMAFPDNSSETEKGISSKPSTSPSVLITTSTQTTASPHAPKIDVTAIHGRVYQSVVDLSRCLADGSLDDPEFSFAGCTRPDCCVEEFDAARPLEELADACVLACDSVVAALLCGPDGPHRVAKMLSFYDSRITPHVPDSQQWEKCRILLVSWYNELSDLRAAVYGAYGNTPTSQHLDERALAARVVSLIAETIGPLVRQDPDRAWVRMGSRDITSLLLRDWRGTNDGDPGLVKAKHLRRTAELLNDGRSSKGTYGVFAPPRRPDQLFRGPGRPRRSTSSSQSASDKSPIKSTHRHTSDPIPISTPRPERDPAGTPHENTMSGPVQPAANGHSCSSTPTPAKKGNKTSSDTISLKDPTKTRIKASAKAQTDETLPETSTAHPSAMDQSSSLERKTLYTGPAVSSKERRRSAQSSTPSDIGGVSRKRKSAPEQYKQGLQTPLPMPEPSVGQTLLDPTTTTHDILSSSLPNRSCSSSPSPSKRPYHPSCYSPTDIMTGALVGPRGRQDRAAFRQFPVGTVIGQTPPQSVLNAYCPNGAFVELVEFARIPEPWQEVLRYSPEAMADIARVANALPGKYNSNEIITSAASEAFHTATSKLRARTAWMRYQQESPDDVSIVVLYSPLPGEHLFCVPAPDTPPGGLKFDNKRGGLSFLLAAFSNRLCLPKSSAWAGRWKAAPDISPLTRMGVLFLSTEDLGYQGAVEYLQRQCMKRKKKLIIMDTVEDRYRLPNGPCIIEEATRYMKCIISPRSQCCVRWPGLRDFGTTIITSRDVVGPLTLMDLEQYYYCEIGIEDSTINLCCTGNVRYTVETRLEDVSCVPTTPLFYFAAVKHVRPDFLCGETYSNRAARKWGLCAPLRPIYVIESKMNAIVSPSFLHPTARNLCRSVILPPDPEARPVVVHIPEGTCSALAEDMVASIRSSCITWGQHEEGGPETTAQENSDIRAMKVRPPTKPPYMSPLNIGNRDTTFTD
The following text describes a protein:
Function:
Active in the repair of DNA damage and in mating-type switching. Probably involved in the repair of DNA double-strands breaks. Has a role in promoting S phase completion.
Sequence:
MSIIQHQSSSGDPNCPQVFTDEEAEHIRLKLSRKLGPEYVSRRSGPGGSSVTYIEAWKVIELANEVFGFNGWSSSIQSIHVDYVDETFDNHRPKYSVGLSVILRITLKDGTFHEDIGYGSIDNCRGKAIAFEKCKKEGTTDALKRALRTFGSSMGNCLYDRNYTQAISRMTPQKKTFDRESLMRPPSVSYPSNRTNYPRTNATSSSNTSSNTNMSPYTKQASAPSPQKPITNRNVPSNVSTNHAQKLPINTNEQKHESAVTTNAAPPPMHNTHPRKRSDTEIYADEDLDTLLLEEAQLEDVGSPKPEEFESILKAMEEFEQ
The following text describes a protein:
Function:
Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system (By similarity). Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity); [Isoform 2]: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein; [Isoform 2]: Secreted.
Domain:
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence:
MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIAFISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDIPIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAATVKQKVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASQGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKSPRRSSSDEQGLSYSSLKNV
The following text describes a protein:
Function:
Probably a component of the fimbrium tip; required for incorporation of FimC and FimD into fimbriae. These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome. They play an important role in invasion of periodontal tissues and are major virulence factors. FimC, FimD and FimE contribute to interaction with host CXCR4 and thereby down-regulate the TLR2-mediated host immune response.
Miscellaneous:
MISCELLANEOUS: The name (major fimbrium subunit) does not indicate the abundance of the protein, but is derived from the greater length of the major fimbriae. In strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, major fimbriae are 300 - 1600 nM in length and about 5 nm in diameter. In contrast, minor fimbriae are only about 80 - 120 nm long. This length difference is observed only in a small number of strains, including strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, and is due to a loss of function mutation in FimB, a protein that restricts fimbrial length in other strains.
Subcellular Localization:
Fimbrium. Cell outer membrane. Note=Probably synthesized as a palmitoylated precursor. Efficient export to the outer membrane and integration into fimbriae requires lipidation and subsequent proteolytic removal of the lipidated propeptide (Probable). Probably part of the fimbrium tip, as a part of the complex formed by FimC, FimD and FimE (By similarity).
Sequence:
MKSKSIIAQLLYVLIAFMAVSCVADKSEPCPSGEPTRVSGSIVSLEHHGLRGASADKENSVERLELWVFDEDGHFLERAVADLSGSTFTAKIIPSEVERRIHFIANYELADPSVWVGRSEREMLPSISVADDLETIRMWARISYPSIAPNQNLGQIQLLRNMAKFSLSVTPPAESKLYDASYALYNSWNKGTLAPFDPNTGSFPQGQITEPAGVVFANPTSEAAFKEADGAHFFYGFERDQSNIGTGAGITCLILKARYNLPNADYTYYKLDFVDTNKVRYNITRNHFYKMILKKAKAPGRPTLQEALDGAAANNIFLSAEVQALPAFSDGSGMLTVDHTYMVFVQGEPSGTFQATYIPQGQNNPDYSKLTVSVSTPTGQQAAVTSAQHEGNGKIKLTLAQQENLTKRSDVVIGVQGNPDLKRSVTVLVREKYQYVFFKANTSSAENNQVTTQISAGQGNELLISAKLPDVLNAALLPITFKVYTEHFYPKTGGMILGIEGGKTLYKYVLTTMPQNKELQFRFKSNKVNSAENIAVKMDYFHDQTIHVTN
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MLHEELSTDMDMITQLQDAILDLLTITSTSIEYITKRTQFEQTSISIPTTLSTPNAANRVEYKAAIETFVADIIRRSKDIQHLIDGLPRPGDSSERAQRLIELQDEIKIANEEYRQVLEQSKELVKELQLALDHTLGESPNDISIQSANYPAGTPYHNQNNEAN
The following text describes a protein:
Function:
Interacts with mus81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Miscellaneous:
MISCELLANEOUS: S.pombe appears to be critically dependent on the mus81-eme1 endonuclease for the resolution of meiotic crossovers. This may be due to the absence of an alternate pathway for crossover resolution such as the MSH4-MSH5 pathway which exists in S.cerevisiae and other eukaryotes.
Subcellular Localization:
Nucleus.
Sequence:
MTLQSTDSAIVIDSEADVDISSSQASPSKDNIALSEHNVITVLDTPQRSTQCDSLLKSFSTPLVSGSEDVLPSPRDALNITNKKSVTDNLLLSLTSSNQSTNTNLNPSSRVEIINLNSSPPNSLSSQPKHQEFHLFHTPTIPRTTQLSSKTSSPIVIPDDNEQVASPLSKKAASLTSSPLKDFQSSPPLSTVLQKSHSLHDILLDTNDDDHFPFTQSPLTKTKSFNDALTSSSSILKPCMPSIASPTSNRLSHAPSTPNLFPNQDSSNTIDLINNRSKTSVENQERTFNLTSDVHLDSPTSPSKHSSIEPNTSQEDSFQELPSLNKLSIQSRAFKKMRLPKISRTTDTPPASTSNSNKKNLDKLKKMRKLCSRSLEPYELDSNTQRKRKRYEDSLKKSKTLDKVDSLNRKMAKELDRKNSKELQKINKVKRTKEECLSEIILLSPDDWASSWYSTVRSQLDSYNCQFVVNSNQPKDSIMWKRKVNNVFNSSTNRFELSIEHEQIEPFALLRLKCRDFIKYIEEDQADTFFHEMSEKFKGCKLILLLEGIPNYFKSLKAELNRQYAAAVNSGTRPLLFGSLSKYQNFTKEKLESEIVRFSFEHSILINTSNDEKETAQWIVSFTGDIALSRYKHFSKFSARASTTEIGHVKSADRIENSLNFMLRQILRVTPNIANAICDQFDSIPSLIHHLKTHGEESLTNVVIQSSISERNLGPVLSRRIYNTFLCKEASSDAP
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MVINKENDLVINKFIANQIEIKAEHIFSPYFRKGLFKVAEIIRGFPMPIEKAKDAECIQGVGSKTIELIGHIIREYNRKKENGGFNNNNMNMNLNTNMNIDTNNNTQIDQKTMAKIPKVFEGYKKPNSVRAILSSVVSICNNNFLLESYLSKLASQAFDDLQTIVNIDLEDLKNLGFPSGHAKAINKEIEKYKEYCEFEKLNPNFKDYFNEEIDFPMDGFDGIPNQPERGYPYLTIDDIKKKCTENVFNYSKEKVLNLGIQSMHFSPEKNQFEAVSESHSNTNITYNLTFNYNENNVLVGDKCSCPSQGREWCKHKVSVFLVLDMLKTNSKCFRLYIDDGNYNTNNTNNNSMDNTNNNNINNNTTLPYFPKVGSGPYSLLMIFYEAQQSNTPDLTKDEAKFHEATLKYISKIENFDNIWASNCRNLTTKHKYIKKMGTKYSLTQDGYNVIKNFLKDKSNPAGYYQDSDEEDTLFDKPILDTKKKKDDSMLYVWTDSDEELTDFMCNNSAIPTSQTKDAVYPEKNLIIEQVVLVIDNRETKDKSNSELIKALSTKPHLRYELRQLPIGDFIFTARCRYRNNPTYTFELLADIVIERKAIPDLSSSLKDGRFKQQKFQLKKLKKYGIKNLIYLVEGSIDLGQMNFDDYMKALLNTQIDDEFTVEVTESTASTCVYLINVYEAISKYRYLSPLKYEDYINIMETPLSLKDQFALQLLQIPGMTPQKTYSIIKKYKTPIQLHNKYKSLQKKPKNKTIVYNEEKQINLFTEREFISKGNKKQKIGSQISERIYNLYNLKDYNINNNNNDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNYNNNNNNNNNYNNNNDNNNYNNNNDNNDNNYNNNNNNNTNNNMYNNDNYNNSNYNTNNNMYNNNINMNNTNNITYDNSNNGDMNSYNNNNNSSYSNNYNYNNFYNHKIII
The following text describes a protein:
Function:
Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity (By similarity). May have a role in the development of the embryonic nervous system and the function of the adult nervous system and muscle; regulating signal transduction in neurons.
Sequence:
MNIGIAAPKWDKLSPREFLQLQELASYSTRKLQDVLREFSSPSAASTPKCIPDGDIDFDGFRRFLDAFLDCEAPLDLAKHLFVSFLKPNVTQAQLHGRALNQMAAISSTAACAPVTSHTKGSIPNINSIAELMPQCSGGGGGIGGTGGVAGAEGHAQARSSFVDKIHGITDKLHHSLGGHLSHDPSKTGSVHPMLTVTPSPLASGPSMFQASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDADIKLLARKLSHFDPLTLKVPLKDVVCYLSLLEAGRPEDKLEFMFRLYDTDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGGMTTIPLLVLLGVDSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCITTYVKSKKPKCGGDLLHHWVEGNCYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASSVKKECTLGEYSELIVPPTAICPAVLDRQRSVNQAHKKSQMHHHQATHFQITPPDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRSEKGRGFFNLLCS
The following text describes a protein:
Function:
Required for peroxisome membrane biogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MIPKQPKSNILIFLLENSDHLGLLKSLITFLPGRYGDSELFSEGLYSVANILQSYLDYRSSGILLSNNIDKISNGEKVPPPYYLTTLRWITTVQSLELFFEMLATKKGEQHDDSNSNNNNSNNNIKKMIIFIIELLKAILRLKLLIKTNGDMLVHHSFYVPSKDVKTILENNRNQQKQFQNKRPAVTMSINNNNNINNNDNNNINNNNNTNDDNFNNNNNNNNNRRTLSDQIFEQQRIVNQENNLLYQQQRELQQNESTLIKLLPPPPPKDYNTKTIGEILFIFRPVIYWVSYCIFGKKSWKPWFLSLVTELLSKSFSEYGNFKQKIRLTLLEAKELNRRKKLLFFYLIRSPFYEKFIGDGLLNKFLNFLKKIHIFKTLIDILINYLNVYRTRYFYTSAS
The following text describes a protein:
Function:
Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.
Subcellular Localization:
Membrane; Single-pass type IV membrane protein.
Sequence:
MSSRWLDDFDAAQALANDIQAACTERTRLRNKGQNATGATNAASNGLKRLAPLLDKLQKQLENDASSYAVTAKEADRRQNQLRQLNSRFKTLEGQFGQGNSNSAMSSDYHRNALYGSAGGRAPVEDEYTRGQDTQALLQEQDRIMDEQDRGLSTISASAQRLKQVGMAIGDELDDQNEMLDELGQGMDITDRRLKRETEHVVYVSEKAKAGGMFCCILLLIIAIIVVAAVPK
The following text describes a protein:
Function:
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as a costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MGTGIPRHPPPPCPLFVAPVEPTGVPTAVPSNASAEPGENGHPPAGQRARGPPRHPHPELPAGPWDTAVLRLAGGSHPCEGAVQVQHRGLWMPVCRDSWSAAASRELCRRLRCGDAEGDAVAVSPDGDGDAAEGCPTAPANCSGWEPRLCAPVLRLAGGRSRCEGRVELRQAGSWGTVCDDGWDLADAAVVCRQLGCGWALRAPREAAFGRGRGPVLRDEVKCGGHEERLAECPAALQHDCSHKEDAGVVCSEHHEWRLSGGKDGCAGRVEVRYRGTWSTVCDSTWYELEAAVLCRTLGCGEPLQRPSFRHTLPTKMLYECVDLQPSLAYCRWTYNKSAPCHESRAAGVVCNGTAPFGPTRRGLGQRPPPPRVVRLQPSPLSPISSANPSSPPSPSCPVSPAAPPALLVAATPSLSLPADPTPATVPTTKGSDSSDSDYEHYDFSSKPPVALSTFHSENPPFLPSGHLPSMLGSPTDPAPPTPQTPSADSRVSSCCCPARMGWSHFPQRVRQPRPPVPQLPVCPSRGGYMVALCSPSDMHPVFPQCRPRSVPSRGAGRGTHPLPPLPPPWSPTVVRAQPPRVPGPARNPHRAAPTSTQHPPVRGLKRLQGWGRPWGWRWQDPLGGESSGDGSGVGETLRDGDSPRRMWGPQGAAGGPGGAHTAPAFPSTPSRALHAHPSAQHAVGTTTPGRPRPR
The following text describes a protein:
Function:
The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2. Important for TATA site selection by TBP. Directly or indirectly regulates the DNA-binding properties of SPT15, the TATA box-binding protein, and the relative activities of different TATA elements.
Miscellaneous:
MISCELLANEOUS: Present with 6510 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MSDLDEDLLALAGADESEEEDQVLTTTSAKRAKNNDQSLSKKRRIEVGSVEDDDEEDDYNPYSVGNADYGSEEEEEANPFPLEGKYKDESDREHLESLPEMERETLLFERSQIMQKYQERKLFRARGRDMKEQQQRAKNDEDSRKTRASTRSTHATGHSDIKASKLSQLKKQRARKNRHYSDNEDEDDEEDYREEDYKDDEGSEYGDDEEYNPFDRRDTYDKREEVEWAEEEDEQDREPEISDFNKLRIGRSFVAKFCFYPGFEDAVKGCYGRVNVGTDKRTGKTSYRMVRIERVFLQKPYNMGKFYTNQYFGVTQGKDRKVFQMNYFSDGLFAEDEYQRYLRALDNSQMIKPSLHSLSNKTKEVMDFVNTPLTDKTTDEVVRHRMQFNKKLSGTNAVLEKTVLREKLQYAKETNNEKDIAKYSAQLRNFEKRMSVYEKHHENDQSDIKKLGELTSKNRKLNMSNIRNAEHVKKEDSNNFDSKSDPFSRLKTRTKVYYQEIQKEENAKAKEIAQQEKLQEDKDAKDKREKELLVAQFRRLGGLERMVGELDIKFDLKF