lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Sequence:
MSSQGSYAKVAESFENISEHSCLSETSGALVDTETISDIKMKGPEVSLAPSSNVTETEESSVSSPQNTDENSGDGYQGYEGDDDDDDDDSNLPSFEDSDNFISSTECSSSPQELEEGEIVEEQSVGRLFHHYELEAGEVVEAQGVQNLFCSYELEEGEVLEAPRVQSMLCHYELEAGEVVEAQGVQSLVQYHELEEGEVVEAQGVQSLVQYCELEEGEVVVAQGVQSLVQHHELEEGEVVEHEIGSLLLRRHHVLDACEIVEEQGLESPFHHRVLGQGVVGNDQDEVSEVYEQNSVERSEQYDIEDSSIDEWMALETSPLLKPRWNVLNALRDRQLGSSGRFVYEACGARLFVQRFSLEYVFEGHAGCVNTVHFNQRGTLLASGSDDLKVIVWDWLHQRPLLNFDSGHKNNVLQAKFLPNCNDAILAMCGRDGQVRVAHLSAMAGTHMTKRLVKHGGASHRLGLEPDSPFRFLSSGEDAVVFSIDLRQAQPASKLMVTKDGDKKVGLYTVFVNPANVYQFAVGGQDQFVRIYDQRKIDENVNNGVLKKFCPHHLISCEYPAYITSLMYSYDGTEVLASYNDEDIYIFNSSDSDGAQYAKRYKGHRNNATVKGVYFYGPRSEFVMSGSDCGHIFIWEKSSCQIVQFLEADEGGTINCIDPHPYMPVLASSGLDHEVKIWSPIAETSSKLTGLKNVIKINKLKRDNFTLHHTSLFDNHMLWFLMSHLTQSNYQRNLRGIRIEVGGGDFSDSSSSSDEEENQDSQCQTS
The following text describes a protein:
Function:
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Subcellular Localization:
Membrane; Single-pass type III membrane protein.
Sequence:
MTGLSMDGGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGANKKRRQITEDEL
The following text describes a protein:
Function:
Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLSIFNIWGTFNRVLFFLSLTVSLAGLAGNTLLLWHLGLRIKKGPFNTYLLHLAAADFLFLSCQVGFSIAKIASGYEDTLYFPVTFLWFAVGLWLLAAFIVDCCLSYMFPSFCGPNCRPRYTSFVLCLVIWALTMLAVLLPANACGLLYNRMSLLVCLKYHWVSVVWLGVLASTACGASMFLLVFGNCCSSQPPSKFCKLAQCSGILLFFCRLPLVFYWCLRPVIKFLLPFFFPLATLLACIDSSAKPLLYYLKGRQLRKEPLQVALNRALGEESQSSSGGISLPMSRV
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MLYKFETKASRVKGLSFHPTRPWILASLHSGSIHLYDYRIKTLLEKFDEHEGPVRGINFHMTQPLFVSGGDDYKIKVWNYKQRRCLFTLKGHKDYIRSVEFHREAPWIVSSSDDMVIRIWNWQSRTCIAELNGHNHYVMSALFHPKDDLVVSASLDQTIRIWDISGLKKKMTTVKPYRENDPMRLQDELFGTDISVRLSLEGHDRGVNWASFHPTQPYIVSASDDHQVKLWRMNDPIVDTFRGHYNNVSCALFHPRQDLIISNSEDKTIRVWDIIKKSTVHMIRRDHDRFWTLASHPNQNLFAAGHDSGMIVFKLERERPLFVQNGDSGVFFLKKKNFNSFDFQAGRTVSLFHISKLPSNNGTQTMSYNQTERAILVSSDAEGGSYHLYKIPPKDSNTVNTKKGTGVAAIFVGRDRFAVLDKGNNVVIRDLENEEIKRCQIPFTIDWIYPSGSPGTILIQSEDKIHMFDIQQKKMLCEIQVHGVRYVIWSKDRNYVAFLTRDFIVLANKKLEQICMIHETVLPKSGVWDDNGVFIYSTSNHLKYLLQNGDNGTIRTLESTIYITGVKNNKVFAIDREFKNRIIEIDTTEYVLKLSLLQQNYNQVMTILRENRLVGKAIIAYLQKKGYPDVVHFVKDDRTRFNLALDAGNIDIALSSAKILDDKDCWNRLGVEALKQGNYQVVEMAYSRTSEFDRLSFLYLLVGNLSTLKKMISYESSDIMSRFHFSLYLGDVEERIKILQEAGLHQLAYITASIHGLTEKAESIGNLITSDGKSQLPQLPKQSYLLVPPSPINCNPNELNWPLLTTTKSVSDVMGENRFGVEQSTSTPTGDWESDEDIFSEGKSQQQSSQQQQQQQQKGDWEEDILIGDGNNGGGDDGGWERDDLKGLEKIGTDGFNNKQNDHVALFVPPQPGPSFSMIWARNSQFAVDHIAAGSFESAMNILNSQIGAVNFDPIKSMFMNIFMATRSSLGCNASTPSLLMPIQRKSAAPYITYGLGHLIERLKTNAYKSTTEGKFNDALSHFTYILHTIIFCSVDNKQEVNELKDLINICREYILGIKIELQRKELSIGAQKDSTLGRQAELAAYFTHCNLDPSHLILSLRSAMNCAYKVKHFNLAASFARRLISLNPNPDLATQAKKVFNFAQQTPTPSDIQQLNYDERNPFVICAHSYVPIYKGSPLIKCPYCSSCYLPTHKGKVCSVCQISEIGKDVQGLQVITIQK
The following text describes a protein:
Function:
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
Subcellular Localization:
Cytoplasm.
Sequence:
MFNVVIVRYGEIGTKSRQTRRWFENILMNNIREALVSEGIDFKKVEAKHGRVLVRTNRAREATEVLTRVFGIVSLSPAMEVDAELEKINKTALKLFRKKKRELNLEKPKFRVTARRITKEFPLKSPEIQAKVGEYILENEESEVNLHEYDIEVGVELMEGKAYIFVDKIRAWGGLPIGTQGKVVALLSGGIDSPVAAFLMMKRGVEVIPVHIYMGEKTLEKVRKIWNQLKKYHYGGKAELIVVKPQNREEMLKKIKELGKEKYTCVLCKFMMVKHADRIAKEFGAKGIVMGDSLGQVASQTLENMYIVSQASDLPIYRPLIGLDKEEIVDIAKKIGTFELSTLPEDEIPFIPKHPVIRGSWEEFRKIYMAIFGEEPRKRDC
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase.
Sequence:
MAESEEYARVISFNNDHDELIIYQETVTDVGGVIWDSALMTIHYFFKYPKPFEGKKVLELGSGTGVGGIALAALGADVIITDLPERLALIEKNVEANRKLTGNRIKVQVLDWTKDRIPEGLDMVLAIDCVYYNSTIDPLITLLNDCDAKEIMVVSEERDIGEAHLAQKSFFKDIQKFFRLELIPQKELDEDYCADDIIIGKLIRNV
The following text describes a protein:
Function:
Transcription factor. Plays a role in embryogenesis and later development, perhaps acting redundantly with forkhead protein pes-1.
Subcellular Localization:
Nucleus.
Sequence:
MSSSFRISDILGTPYTPPSPKREVDEEEDSPVLPGSGGYPPASLDLPPLTPFFACNEQLLATLHEASHDDDSLLSLLLPASPSSLQSSSFDSGAGSAGAGESEPGAGAGDPDDAAGAGTGNKENAAVAVCEVDDPARRPNLSYNALIMMAIRSSAEGRLSLAGIYEYITTHYAYYRHSKDKNWKNSIRHNLSLCKSFLRVPREFGDPGKGAYWTIDPRADEELTLHSTTGKLRRRRSTATAFQPLNFAAAASPYPNFAAAHQQLLYTPPPPPPPSFLPTSAGSFPLLPLMGLPHIDPRLLAGLLT
The following text describes a protein:
Function:
Required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photorelocation movement via cp-actin filaments regulation.
Subcellular Localization:
Cytoplasm.
Sequence:
MEDLKTVEASDNVVSDNVEKVNPELIDSTIRESNIQSATKVDNIPQSQTDTEETQQSQTDTEETQQSQTDDTTGNAKIYVDDTFSPSDAATAAVLTGKDSTSTTIVEEVMEPDEIGLPSVKITEAATGTARNGGGSPRTVSSPRFSGSPVSTGTPKNVDSHRGLIDTAAPFESVKEAVSKFGGITDWKSHRMQAVERRKLIEEELKKIHEEIPEYKTHSETAEAAKLQVLKELESTKRLIEQLKLNLDKAQTEEQQAKQDSELAKLRVEEMEQGIAEDVSVAAKAQLEVAKARHTTAITELSSVKEELETLHKEYDALVQDKDVAVKKVEEAMLASKEVEKTVEELTIELIATKESLESAHASHLEAEEQRIGAAMARDQDTHRWEKELKQAEEELQRLNQQIHSSKDLKSKLDTASALLLDLKAELVAYMESKLKQEACDSTTNTDPSTENMSHPDLHAAVASAKKELEEVNVNIEKAAAEVSCLKLASSSLQLELEKEKSTLASIKQREGMASIAVASIEAEIDRTRSEIASVQSKEKDAREKMVELPKQLQQAAEEADEAKSLAEVAREELRKAKEEAEQAKAGASTMESRLFAAQKEIEAAKASERLALAAIKALEESESTLKANDTDSPRSVTLSLEEYYELSKRAHEAEELANARVAAAVSRIEEAKETEMRSLEKLEEVNRDMDARKKALKEATEKAEKAKEGKLGVEQELRKWRAEHEQKRKAGDGVNTEKNLKESFEGGKMEQSPEAVVYASSPSESYGTEENSETNLSPQTKSRKKKKKLSFPRFFMFLSKKKSHNN
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MELSPPVKPPRGVKPVKETSGLLMSVIRTLSSSETNEQRDKEKSKLETEYKNCDRKLDELVSKHESDLAKVMQQFAAISQIVSDNRLKIAKVKEHLQDCKRKLRCRRDELRNLWLEGLEYKYMLQLLDEIEKMSQVPDRLSNFMSHKQYLHATELLVEAVTLGKNTLEGVESLKELSRELEQKKEQLHLQLFAELKEHLFTRPAQRVLALRRQESGRDNFLINSPLQRSTELRLSRNRMAVRRNIFESAQKLDNFNVVEDLTTANPEENSYHFIVILIKCLALLDKLPFAVSRIKEEMQVFLLGIIQRSTQHIKDFAGLQTETDYKQALKELVQTLFEQFKEVAEAQLVFLRNVEEAAKVHNTQVSTYSIQFYWTQVQSVLEIFLNEYLDVQNTSTESHVSNKSDANDLSSYFGRRKQPIKKKSLFKFDSSSSALTLSSTLKSTKKDKILVCRSHSNNILIVFIPFMCFIEEVEQVLGQNGPCQLHRFITQYVSEVYLKRKSDEIIEQIETAVRAADAWKATVLLDCTADYKPLLVSTASVERCIREWKAVLQALPIYSERIAVYSCKALKEYKDTCFAAYSGIVQPHSEDRRICSAAWLKDEDISRFLKSLPNWVNLKAQQEYHARSERIRRALRREQRSEEESPEDVRKRNRREAEILASNLGEGGVSASEILSDMALLKELAQLQESMEWFSVRMFQYTSEFRHEPAGLSPSKPDSEMEGIAPVSGAVLQQLTSLAQEFDELANTCLLLLHLEVRVQCFHYLLAQTHLNRETHEPDPKVLELSRVLANVDEAVTSSLHPRKCKYIFEGLGHLIAKILISSAQYLQTIDEAGIQRMCRNIFALQQTLTNITMTRELALDHARHYFELFFLTPEEILNGIVEKGPEFSELEYMNAFQLLNRSQADREHGSVTVHLERLSDILGEVGMTV
The following text describes a protein:
Function:
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MWRCIARGLRGPASTRSTSNHSLGSQLSRFFSSGANSSYTVVDHTYDAVVVGAGGAGLRAAIGLSEHGFNTACITKLFPTRSHTVAAQGGINAALGNMTEDDWRWHMYDTVKGSDWLGDQDAIQYMCREAPKAVIELENYGLPFSRTEDGKIYQRAFGGQSLNYGKGGQAYRCACAADRTGHALLHTLYGQAMRHNTQFFVEYFALDLVMNSDGTCQGVIALNMEDGTLHRFKAASTILATGGYGRAYFSATSAHTCTGDGNAMVARAGIPLEDLEFVQFHPTGIYGAGCLITEGSRGEGGILRNSEGERFMERYAPTAKDLASRDVVSRAMTMEIREGRGVGPLKDHIYLHLNHLPPDVLKERLPGISETAAIFAGVDVTKEPIPVLPTVHYNMGGIPTNHYGEVVTIKGDNPDAVVPGLMAAGETACASVHGANRLGANSLLDIVVFGRACANRVAEIRRPGEKQKPLEKDAGQRTIAWLDKLRNSNGSLPTSQIRLNMQRVMQTNAAVFRTQETLEEGCQLIDKTWESFHDVQVKDRSLIWNSDLIETIELENLLINACITMYSAEARKESRGAHAREDFKVRDDGSWMKHTVGFWENEKVRLDYRPVHLNVLDDEVESFPPKARVY
The following text describes a protein:
Function:
Receptor for basic fibroblast growth factor.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MVQHLGTPQLTPSSPVTIVEGDDLSVVCSVTSDPASPTLQWSKDGTREPAGATLRKNPVTQSDAGTYTCTATNACSTSAQLVVDVQYPPDGNPVCTVTTSGNNVVLRCELQGGNPAVDLVWTYGNGQSAGTSQESVNQVNAPVTAEGTTYTCTATSVALNPGRTCSATLAAPSVTVSPQPTSTVLLGTASHSLTCTVDSPGVPAASALTWTGPAVTAGRTTGGTLTTPSLTISGVEKTDAGDYTCTATNLVGDGSDSLSLVVQYPPELTVTATPNPVDETQSVSLTSVSCQCSRHADSIQGQGQGQGQCICRRGWRGNGTFCEPLSDTLEVELLVIGENWRPGLDDCASVDFQTLANRFDKEIRKFYRDHLVAVLSLAITRFFDGSLYVVHTVTFPNHMEHHHLIEMFEEFDNDTGLYFDGHAVRELCHVGFCENDGTCREEGFDRVCDCPSGYSGLLCENQGPGGDNTTTIIIAVVVVCVIVLLAVIAVAVVVTRRRKSAANKKTVENHVNNINLDHVQGEADDGYQSLRIPHRQSSDHTYQGLTARSDKELASDGAYEDVKTPSEFPRNQLAIKEELGHGEFGCVYKAEAWNISGSVGTTVVAAKELKGMSPTASTAFFKELAVLKLLGTHPNVVSFLGCCTDAEPFYLLLEYVSGGSLQSNLRTSRTQQTYGNLHGGSKSLSSRDLTKFAWDVAKGMSFLSAKKIIHRDLATRNVLVSADRTCKVSDFGFSREGDEYERTTKVSTAVPHFPRIYHSS
The following text describes a protein:
Function:
Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.
Subcellular Localization:
Mitochondrion.
Sequence:
MSAWAAASLSRAAARCLLARGPGVRAAPPRDPRPSHPEPRGCGAAPGRTLHFTAAVPAGHNKWSKVRHIKGPKDVERSRIFSKLCLNIRLAVKEGGPNPEHNSNLANILEVCRSKHMPKSTIETALKMEKSKDTYLLYEGRGPGGSSLLIEALSNSSHKCQADIRHILNKNGGVMAVGARHSFDKKGVIVVEVEDREKKAVNLERALEMAIEAGAEDVKETEDEEERNVFKFICDASSLHQVRKKLDSLGLCSVSCALEFIPNSKVQLAEPDLEQAAHLIQALSNHEDVIHVYDNIE
The following text describes a protein:
Function:
May be involved in pectin and/or xylans biosynthesis in cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MMVKLRNLVLFFMLLTVVAHILLYTDPAASFKTPFSKRDFLEDVTALTFNSDENRLNLLPRESPAVLRGGLVGAVYSDKNSRRLDQLSARVLSATDDDTHSHTDISIKQVTHDAASDSHINRENMHVQLTQQTSEKVDEQPEPNAFGAKKDTGNVLMPDAQVRHLKDQLIRAKVYLSLPSAKANAHFVRELRLRIKEVQRALADASKDSDLPKTAIEKLKAMEQTLAKGKQIQDDCSTVVKKLRAMLHSADEQLRVHKKQTMFLTQLTAKTIPKGLHCLPLRLTTDYYALNSSEQQFPNQEKLEDTQLYHYALFSDNVLATSVVVNSTITNAKHPLKHVFHIVTDRLNYAAMRMWFLDNPPGKATIQVQNVEEFTWLNSSYSPVLKQLSSRSMIDYYFRAHHTNSDTNLKFRNPKYLSILNHLRFYLPEIFPKLSKVLFLDDDIVVQKDLSGLWSVDLKGNVNGAVETCGESFHRFDRYLNFSNPLISKNFDPRACGWAYGMNVFDLDEWKRQNITEVYHRWQDLNQDRELWKLGTLPPGLITFWRRTYPLDRKWHILGLGYNPSVNQRDIERAAVIHYNGNLKPWLEIGIPRYRGFWSKHVDYEHVYLRECNINP
The following text describes a protein:
Function:
Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization. Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations. Involved as well in cell migration and invadopodia formation during wound healing. Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells.
Subcellular Localization:
[Isoform 2]: Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cell projection, ruffle. Note=Colocalizes to dynamic vimentin filaments both in the central cytoplasm and at leading edges of migrating cells. Colocalizes with F-actin, Arp2/3 complex and cortactin to leading edge lamellipodia, ruffles and macropinosomes of migrating cells.
Domain:
The N-terminal leucine-rich repeat (LRR) domain is necessary for localization to vimentin filaments. The C-terminus is necessary for localization to the cell membrane.
Sequence:
MAQTPDGISCELRGEITRFLWPKEVELLLKTWLPGEGAVQNHVLALLRWRAYLLHTTCLPLRVDCTFSYLEVQAMALQETPPQVTFELESLRELVLEFPGVAALEQLAQHVAAAIKKVFPRSTLGKLFRRPTPASMLARLERSSPSESTDPCSPCGGFLETYEALCDYNGFPFREEIQWDVDTIYHRQGCRHFSLGDFSHLGSRDLALSVAALSYNLWFRCLSCVDMKLSLEVSEQILHMMSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGALRRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNPGALGASEDSGGLYSFLSRPNVLSFLNLAGTDTALDTVRGCSVGGWMTGRADWRAGRGGLGPPAGVANSLPPQLFAAVSRGCCTSLTHLDASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGAVSSLDLADNGFGSDMVTLVLAIGRSRSLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDDCPLQSLSVAESRLKLGASVLLRALATNPNLTALDISGNAMGDAGAKLLAKALRVNSRLRSVVWDRNHTSALGLLDVAQALEQNHSLKAMPLPLNDVAQAQRSRPELTARAVHQIQACLLRNNRADPASSDHTTRLQPLGLVSDPSEQEVNELCQSVQEHVELLGCGAGPQGEAAVRQAEDAIQNANFSLSILPILYEAGSSPSHHWQLGQKLEGLLRQVGEVCRQDIQDFTQATLDTARSLCPQMLQGSSWREQLEGVLAGSRGLPELLPEQLLQDAFTRLRDMRLSITGTLAESIVAQALAGLSAARDQLVESLAQQATVTMPPALPAPDGGEPSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPTRPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRPGPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTEPLPPQPTEPSSPERSPPSPATDQRGGGPNP
The following text describes a protein:
Function:
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
Subcellular Localization:
Cytoplasm.
Sequence:
MSAELIAVYKDEQIIDLESAKVLGLSDGIKALNGTEPIYFDDSPLALEVIRHSCAHLLAQSLKALYPDAKFFVGPVVEEGFYYDFKTSSKISEEDLPKIEAKMKEFAKLKLAITKETLTREQALERFKGDELKHAVMSKIGGDAFGVYQQGEFEDLCKGPHLPNTRFLNHFKLTKLAGAYLGGDENNEMLIRIYGIAFATKEGLKDYLFQIEEAKKRDHRKLGVELGLFSFDDEIGAGLPLWLPKGARLRKRIEDLLSQALLLRGYEPVKGPEILKSDVWKISGHYDNYKENMYFTTIDEQEYGIKPMNCVGHIKVYQSALHSYRDLPLRFYEYGVVHRHEKSGVLHGLLRVREFTQDDAHIFCSFEQIQSEVSAILDFTHKIMQAFDFSYEMELSTRPAKSIGDDKVWEKATNALKEALKEHRIDYKIDEGGGAFYGPKIDIKITDALKRKWQCGTIQVDMNLPERFKLAFTNEYNHAEQPVMIHRAILGSFERFIAILSEHFGGNFPFFVAPTQIALIPINEEHHVFALKLKEALKKRDIFVEVLDKNDSLNKKVRLAEKQKIPMILVLGNEEVETEILSIRDREKQDQYKMPLKEFLNMVESKMQEVSF
The following text describes a protein:
Function:
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MDPWPWLTAALLLLLLLVQLNRTARFYVKVGLYCVLCLSFSAAASIVCLLRHGGRTVDNMSIISWFVRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFINRQQAKTAMSLMADLGDLMVKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYSSFSSFYNVKTKLFTSGTIRVQVLDAVPTNGLTDADVTKLVDTCYQSMRATFLQISEIPQENSTIKESGVLPAQ
The following text describes a protein:
Function:
May be involved in positioning the proximal bud pole signal.
Miscellaneous:
MISCELLANEOUS: Present with 952 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Bud neck. Bud tip. Note=Found at the birth scar and the necks of large-budded cells and the proximal poles of daughter cells.
Sequence:
MTKITRDVSITTENSKSTSGSATASSASLPENDHPIFHQPRARIRSGSLFIEGSDSFPSSEVKSYNVYIDDSKYSEILKGDTNSSSTDGKQVFEDARDDNFHQESHRDLEDSILDLVRRDPEVAAFPLPPPNSNERNRNSSNGSSAETNLNGHSSSGTISTSVLLNMGSAEKHAGTTRGDHMESSSMKSFEKLGTRPSSLFYPPPEGTAPYQGPRATVSGNKSTRQTQGTYSFPSMRYGVDLVSPVEGAVDVAKSRVPNSTLNGTFPDKAFIPHEFQIPKKAWNRIPANKSTSLKTPRNHSLLIDILKPFEAADLANDQRSSSAVLKNTVHSNGQYNPTNETSGTRMQDQRQKNTNEIDLEKIPNPQVPLGIAMDTMRSPNQLHEKEYESNIEAGLASGVGKGDNSIKQHQYKKIPQEIDRDQQLSFQMETMPIQRIDSSSIRSFDSRIYGFSEIYSIPRVITTLCICLFVPPLFFFFSINGNNGVSNYRLMRMIMNYEHRIGLLKGFEWDIDVQWFRTLCFVLGCIEMLAIFASIGIGFGVGIIRE
The following text describes a protein:
Function:
Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes; In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.
Sequence:
MDRIRYTDFATDDGVGMMSDMRHYNIMEMNEMAAIAHEMMYATVLSTSRRISKRKRSSAWLSMGVTSVIMCLFVHISSGGNMLVTASNDKPTPLVQRRGRGVGIGRQPNSEQTSRAAYSGSSSPSANDTKMDVTSSKSNKSDKSSSIGSGKSGKGSKSAGATTPAPTNPKEGLLGPTPSPTESSKPTVSIVPTPRLTLYPSMQPSYHPSGEPTIEESVVPSLHPSNSPTPMPSIAGSGHPSSYPSASPTDMPSIHGSEEPSSSPSTSPPSTIPSLRPSMNGTMVPSSSSAPTSSTQVPSGMPSSGGTTFVPTIEMIGTDMPSAGASSLEPSISNAPTSIPSSFSSMNGTLFPSASSSPSITNSTIPSESPSVFGLINGTTPSPSNTDQPTNTIVMDRRSNLRMGLFGITSLDADQTAVFEEETAVYIETFYNNATEQDSILDVVKGRVFGVIANVVVTDFTPGGDTMPQESGITDVTEPCEGDIPVDVIFTLELQYHTLDEELKESDLILTFPFRSTRFRATYIDDYLKIDDGVVFNDLYCTSRLEIPGNMTTETPTSFPTGNGTSFPSISSAPSSNETLFPSISSAPSVSSVPTALNTSLFPTISNPPSALNVSLFPSASSAPTALNTTQIPTVSAPPSSNNNTLFPTVSTSPSSNNNTLFPTTSAAPSSNNNTLFPTLFPTTSPAPSIVNATSNQTLFPTISTAPSISAQPSIAVPPFEMNMFGLTSDLVSPGPEIYNHRTALYIEEFYNNDDSTDGIRGSVSDVVATVTINDQITPSSAVRSSFNTKSASIVVHQGPRKKRGKHDDEKDFLPIQKRFGSVGHSGRSLQEDPCSGSFLTLVLAVTVEYQSSDASLTPEDIIAEPFSTAEFRDLYMNDYLKSNTGAVTFVFNDLACTGEMIASNDVSLMPTTSSDGTAAPSPTLYPLSDTRTNLEIDLFGKVNPLNPPDRSFFESQTALYYSEFFSDPNTPITEVLASAVSITDQITPSGNPLGKACSEMNLETDGLTIVFTLDLTYTVTDPSVDFDIIIQYPFSTEEFRDKYLNEYLKSNLGRDFGSVVCASEVRIPRDVIMPPSPSTSPGMVNATTSPTLKMVDDIFNDDLARVRRSGPSYDRKCDAQLESEMNKATKEYEISFMYGVETNTDSYYFIDDLENLILDFVATSVLRCFGIGQQSVQLRRKDDEAKCDPKSPGAQGCAILTSKLLVTTMDVSLSDVHRGILMVLTDAFEKGIFTEFIPDLIYSSYLGPDANTISVGAAAMEVKSGGASSQAGLIFAICSAVMVAVIAMGASCVAFPLARKELINNTLSSFRWRRNRHLAVCSEDVLESTSSVLIINRARSEEDAEHLLH
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MALEWAALGAVTAAEALILLLLTMPGLTGIRKGLISVARSALRPLLAVVPLALFLALEIYWKFDHMPECKGPQCDPLQRDRAAKSLMKSQRNAILVGGALLLYWVLYRVTAMMVRMEQLSTQLKKMKSSE
The following text describes a protein:
Function:
GPI-anchored hyphal cell wall protein required for hyphal growth and virulence. Involved in innate immune cell evasion through conferring resistance to neutrophil killing. Binds kininogen, the proteinaceous kinin precursor, and contributes to trigger the kinin-forming cascade on the cell surface. Production of kinins is often involved in the human host defense against microbial infections.
Subcellular Localization:
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKVVSNFIFTILLTLNLSAALEVVTSRIDRGGIQGFHGDVKVHSGATWAILGTTLCSFFGGLEVEKGASLFIKSDNGPVLALNVALSTLVRPVINNGVISLNSKSSTSFSNFDIGGSSFTNNGEIYLASSGLVKSTAYLYAREWTNNGLIVAYQNQKAAGNIAFGTAYQTITNNGQICLRHQDFVPATKIKGTGCVTADEDTWIKLGNTILSVEPTHNFYLKDSKSSLIVHAVSSNQTFTVHGFGNGNKLGLTLPLTGNRDHFRFEYYPDTGILQLRAAALPQYFKIGKGYDSKLFRIVNSRGLKNAVTYDGPVPNNEIPAVCLIPCTNGPSAPESESDLNTPTTSSIETSSYSSAATESSVVSESSSAVDSLTSSSLSSKSESSDVVSSTTNIESSSTAIETTMNSESSTDAGSSSISQSESSSTAITSSSETSSSESMSASSTTASNTSIETDSGIVSQSESSSNALSSTEQSITSSPGQSTIYVNSTVTSTITSCDENKCTEDVVTIFTTVPCSTDCVPTTGDIPMSTSYTQRTVTSTITNCDEVSCSQDVVTYTTNVPHTTVDATTTTTTSTGGDNSTGGNESGSNHGSGAGSNEGSQSGPNNGSGSGSEGGSNNGSGSGSDSGSNNGSGSGSNNGSGSGSNNGSGSGSGSTEGSEGGSGSNEGSNHGSNEGSGSGSGSQTGSGSGSNNGSGSGSQSGSGSGSQSGSESGSNSGSNEGSNPGAGNGSNEGSGQGSGNGSEAGSGQGSGPNNGSGSGHNDGSGSGSNQGSNPGAGSGSGSESGSNAGSHSGSNEGAKTDSIEGFHTESKPGFNTGAHTDATVTGNSVANPVTTSTESDTTISVTVSITSYMTGFDGKPKPFTTVDVIPVPHSMPSNTTDSSSSVPTIDTNENGSSIVTGGKSILFGLIVSMVVLFM
The following text describes a protein:
Function:
ER-bound oxygenase; part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893 (By similarity). MpaB catalyzes the oxidative cleavage the C19-C20 double bond in farnesyl-DHMP (FDHMP) to yield FDHMP-3C via a mycophenolic aldehyde intermediate (By similarity). The first step of the pathway is the synthesis of 5-methylorsellinic acid (5MOA) by the cytosolic polyketide synthase mpaC. 5MOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHMP) by the endoplasmic reticulum-bound cytochrome P450 monooxygenase mpaDE. MpaDE first catalyzes hydroxylation of 5-MOA to 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoic acid (DHMB). MpaDE then acts as a lactone synthase that catalyzes the ring closure to convert DHMB into DHMP. The next step is the prenylation of DHMP by the Golgi apparatus-associated prenyltransferase mpaA to yield farnesyl-DHMP (FDHMP). The ER-bound oxygenase mpaB then mediates the oxidative cleavage the C19-C20 double bond in FDHMP to yield FDHMP-3C via a mycophenolic aldehyde intermediate. The O-methyltransferase mpaG catalyzes the methylation of FDHMP-3C to yield MFDHMP-3C. After the cytosolic methylation of FDHMP-3C, MFDHMP-3C enters into peroxisomes probably via free diffusion due to its low molecular weight. Upon a peroxisomal CoA ligation reaction, catalyzed by a beta-oxidation component enzyme acyl-CoA ligase ACL891, MFDHMP-3C-CoA would then be restricted to peroxisomes for the following beta-oxidation pathway steps. The peroxisomal beta-oxidation machinery than converts MFDHMP-3C-CoA into MPA_CoA, via a beta-oxidation chain-shortening process. Finally mpaH acts as a peroxisomal acyl-CoA hydrolase with high substrate specificity toward MPA-CoA to release the final product MPA (Probable).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MSLPLPPALSELARALPYSRTQWLPIFVGFLIGYPILIRALRYKRHGEMKKKFYFPTRESMAEMTDEEAFLIQKEMAQLEFPFMFLTSGQFALFRTYGIPTISHLLTKTGQFSKPETSFKRYTDTAALIGEMVENSPTSQRAFISVARTRFLHSGYQASGKILDADLLYTLALFAVQPVRFIENFEWRTLSDLELCAIGTFWKSLGDALGISSEILPSGKTGFKDGIQWLEEVDVWSQDYEAKYMVPDPKNRESADQATAMLISNRYEAPTPGWSMVFSTLLAIRKLILRYLSPPRPAALAVSNIAQKPDKDDRYHRMSWDALPFYIRPTFWNRWGPMAWISWLMGHPVPGDLGQKKGPQGDPGNDEGIKDLKDGEMSLPLVWSKYHATTND