lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates trimethylated 'Lys-27' of histone H3, a mark associated with transcriptional repression, thereby playing a central role in the histone code. Involved in the transcriptional regulation of the heat shock response, unfolded protein response and possibly other stress response target genes. Required for gonad development and organization. Required for the robust transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development. Acts cell-autonomously in Y-to-PDA transdifferentiation, which depends on the demethylase activity and on recognition of the H3 tail. Cooperates with set-2 and unc-3 to ensure robust Y-to-PDA transdifferentiation. Promotes mitochondrial stress-induced longevity. Involved in lifespan regulation.
Subcellular Localization:
Nucleus.
Sequence:
MQGKNSHLTGITGTTHFTIFGASPRSMSLVKNSQETPPFPGMNSTMRPVEFNSTKQPEAQTIDQEQDAPKSFDFKNQTLGVYSDTVLNPLKNDSFKDELVVDVQKNLPIESLTVSPKSSTDQNCRSTNEAIRIAGFDNFADQLQESNGVFEACPEAHSEQGNESEDFKDLINSETECNIEDVVLPTVHVSTDSEEIISGDVIMNDSNVVSKPKNLEKVETPDVLIGSGSNDKLSDMTEQIGNNQHLEKLISEKTEKSLSDNETTLKPVPVQHTNSVGSSIGTTSGDSEISDDDQKSWSPKNESLDYQPASTSSEFTETTSVANQTESNAGSVDDYCPRTSIDIGLDSSAPSCSSDATREPTPIKKRGRKKKEQSATEPPIPRTKRAYTKNPNTIRKRRMKKNQSDDEEDDGPPKRRTINYQIEFRDASGAWTMAQQLIFVRDFMSKKNDKIVKLSKSRQDRVDKFILQFQKTQDSHYMRAAIQLNTIFPDQGNYRHCQDYLKDLTIRVVVPPKRREGKRKSEVPANPPALLLTGPLYLNFYCTSQEVLEAAGQLLEFHVNAVYKDERLQPPVADKTLLDLERAMYHEQVKDLTDYHKYRIPCPTLTVTTKEEVFSSDFERILNSASITNISGIAKALNIKTELFSLPEIAKCHPELSIDILNQVPQSADGNCDSKGIRCWDVTSYSSKMKLQDFERYMQKEESEAMQAFETISNCTAKELESTCQKLKAERIAAQNAIEGCDETMPWIKFGTNIDLLSENFKKQMNEIEKLPTFLLPNREGNLLNYAGVDVLGINTVQMYAKPIGSRTPAHMENSLMASINWNRGPGTCVWFAVPYEYWGQLEFMIGEHGHKYQDQDYWPSEKELLELGVPVIKFEQKADEMVYVNTGCFHWVQSNSFCINVSWNVGQPNFTQLATSIVAHDHNMLIGNQAHVPLVNLVWNAARQRLFVDDPEMYKAMRGVMIRSLAHSKWYFDLIDHHDYIVGDASEWKLADRVQRCKYCTSEIFNIVRWYTTEDLSVDSYPFCSHCHVANEYKKDRFLKYTWFFSLETLVNIFDAYVPN
The following text describes a protein:
Function:
Involved in the early secretory pathway. Required for the correct export of secretory products from the endoplasmic reticulum (ER) and involved in the maintenance of ER integrity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGSAGVASSSSDVAISALREKHEKEVENLTLTTQPLNTLKLFVEATIQYIKRSISYLLAHGGWFILITTLLVVSGGLLVTVDGPHGKHVEEVLEYVRYGLWWIALGVASSIGLGSGLHTFVLYLGPHIALFTLKATLCGRVDLKSAPYDTIQLKRVPSWLDKSCSEFGPPLMISAAGSRVPLTSILPQVQLEAILWGIGTALGELPPYFISRAASISGSTVDGMEELDGSSTEDSGFMATHLNRVKRWLLTHSQHLNFFTVLVLASVPNPLFDLAGIMCGQFGIPFWEFFLATLIGKAIIKTHIQTIFIICVCNNQLLDWMENELIWILSHVPGLASMLPGLTAKLHAMKEKYIDAPSPVPSHIKVKKWDFSFASIWNGIVWLMLLNFFVKIVTATAQRHLKKKQEKEMATLTHSD
The following text describes a protein:
Function:
Heme transporter required for the export of intestinal heme to different tissues and subcellular compartments. Also, required for the export of vitamin B12 from the intestine of the mother to the embryo to support embryonic development.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MPSDSEEVCLQQSGTGVYENVVYSKETSDRAKRYAGDTNRKTIGRYSAAVQNLIPLRTTERNKNNGGSRIDDAGLFSFVTYSWVFPYLYQAVRGKLDRNQVWGCSFYDSCGLNMARLEVLWEDEKKANAKSPSLFKVIYRFISTRLWFSCAVFFFCLIFGFIGPTCFIRRLIAFAENPERDEQSRIVYSYGIALVAAISVVEFARVLSYGATWAVSYRTGIRVRGAVLALLYKNVLNSKDLCGKTESDVINIFANDGQRLFDAVTFAPLVLVGPLVLVGGIGYLLMVIGRWSLLGILVFFVFDVIQFGLGKSMVACRNLAIVKTEKRISMMAEIIKYIRIVKMNGWEQIFSAKIDQFRKEEKVQIRKSGYAQSLAIACGPVVPVVAAILTFVGVVLAGNDLLASDAFSAITVYFVMLFGIRMIPYGSRYLAEAVVAMRRIQEYLLLEQYAPYPVTNAEDVVLDCQGATYTYQPKAAKAPVDETKEPTENEVIVVETPVFTCSFDKLSIKRGEHIAVIGAVGCGKSAILKAISGHMFTTDDALSVDRSQTVYVPQKAWIFNGTVQDNILFGDKMNSERYYKAVNGCQLTEDLTTLSVGDRTEVGERGATLSGGQKARVALARAVFQTKNLYLFDDIFASLDKKVANKIHEEIIQKLLKKKALMMVTNNMELLHHFDRVLFVEGGNIVADGNHDILYEKNDAYKTFVDACETYQATSGATSPCGDGPAQPAPLDAEILRNSSEDLKGDADKLISDEEDMGNSTIAWRIYKQYIHAAGGWPIWTCLVIGFIVNVVSNIFSTYWLSRWLKKGHDETTTITNGTEFLEMKTSLADSPVTGFYAAVYLVALVVLTISGLFKACVFVKVSLTAATRLHDRMFQAVIHGATSFFDSTPTGRILNRFSKDMDEIDVKLPFTAEVFLQNMITCLGFLVVITSVFPYFLLFAIPLFVVFVVFVSCFRAGIRNLKRSEHISRSPLYDHVSASLEGITTIHTFQQSNRFLEVLKKHLDCNSGAIFMFQSAMRWLAVWLDLLVVVMTAIVALLTVMLTGTVSPADAGMAIAFAVQMSGIFQFAVRTQTELEAKMTSVERVSYYADNIPEDGEWNTRQGLDIESSWPANGQINFSEVNLRYRKSHPLALNDITFEIKGGEKVGIIGRTGSGKSSLANLIFRLYPVTNGTIYIDGVDIRTVGLVKLRRGISAIAQDPSLFSGTVRFNLDPSLEYSDSMIWEALEKCHLKTLVQSLDKKLEADVSHGGNNFSVGERQLFCLARALLMKSRIVILDEATASVDAGTDKLIQEVIKTVFADATVIIIAHRLDNVRNMDRIMHLKNGKLINFTTPQEMFKDDWSVYKLEDKDDDQHSAVVVGENSEHSMEKSSQGSSQESDDIVKVENEQKDSSDDVVHIESGDDDVKADSSEVKETSSDTDIEVVQ
The following text describes a protein:
Function:
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Sequence:
MKQGFAVRKKIEEIKNQGKKAFIPYIMAGDPNLEETAKRLKILEQAGADLIELGVPFSDPLADGPTIQKAAERALNSGTTLRKILNFLEDFKKSINTPIILMTYLNPVFCYGIERFFHDAKGVNVGGVIFPDLTVEESKYYRTFAKKYGIDTIFLVAPTSTPERVKKIVKASTGFVYYVSITGITGTTLSLDKSFNDHINFVKSFGKPVCVGFGVSKPEEAKYISRIADGVIVGSAIVKIFHEKPEKASEFIKSLREAI
The following text describes a protein:
Function:
Gamma-glutamylcyclotransferase acting specifically on glutathione, but not on other gamma-glutamyl peptides. Allows utilization of gluthathione through subsequent cleavage of the Cys-Gly dipeptide by Cys-Gly metallodipeptidase dug1.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKTLSPEGSLWVFGYGSLIWHPPPHYDYSIPCFIKGYVRRFWMRSEDHRGTVNSPGLVLTLIPYEEWKQFSDWSFTPFDEGCWGMAFRIPAKYATQVREYLDDREVNGYTAHSVPVYAHTGDEIPVLENCLVYVGTSKSPQFQPSDDLTQMAKIISTRRGKSGDNFVYLFELAKCLRHLSPESKDIHVFELEAEVRKQMQKTR
The following text describes a protein:
Function:
Prokaryotic-type aspartate aminotransferase. Also has a prenate transaminase activity. Involved in the aromatic amino acids biosynthesis pathway via the arogenate route. Required for the transamination of prephenate into arogenate. Required for early development of the embryo.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASQSSVAVISSAAARGESFPDSKKPIGSVRFQQPLRLSFSYCKSGNMSSRICAMAKPNDAETLSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPLRATVSV
The following text describes a protein:
Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVVVTQRKVPDKLLDSNTVTHLFRITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRMADISQVYTQNAEMRPLGCCMILIGVDEEHGPQVFKCDPAGYYCGFKATTAGVKQTEATSFLEKKVKKKLDWTYEQTLETAISCLSTVLSIDFKPSELEVAVVTVQDPKFKVLTEAEIDTHLVALAERD
The following text describes a protein:
Function:
Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSIWEVILAFVVVVLMLVALLANVLVLMCFLYSADIRKQVPGLFILNLTFCNLLMTVSSMPLTLAGIIYKRQPGGDQICHVVGFLETFLTTNSMLSMAALSIDRWIAVVFPLSYHSKMRYRDAALILSYTWLHSVSFPIVAASLSWVGFHHLYASCTLYNKRPEDRTQFVIFTGVFHTLSFLLSLIVLCFTYLKVLKVARFHCKRIDVITMQTLVLLVDIHPSVRERCLEEQKRRRQRATKKISTFIGTFILCFAPYVITRLVELSSTIPINSHWGIISKCLAYSKVVSDPFVYSLLRNQYKKTWKDIINKILKRSSINSSALTNCRNSKKGNGEPPSSWDLIQQDRSPKEEGNKCFQM
The following text describes a protein:
Function:
Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
Sequence:
MTTDDMTRLAALGPLDGRYRADVASLASFFSEAALFRYRVRVEVEYLIFLSRARGIHFVPPLTPPQQAALRALYRQFGDDDALAIAAWDRRVNHDVKAVEYWLRERLTTLGLTGHLEAVHFALTSEDVNNLAYALMVKEAREMVLLPALESLLERIRQLADEEAATPMLARTHGQPATPTTFGKEMNVFFMRLRRAINDMMAIKITGKLNGASGVFAAHHVALPQIDWLKFSRAFVRSLDLEPILLTTQIEPHDTLAALCDALKRIGAILTDLSQDCWRYISDGYLVQAARAGEVGSSTMPHKVNPIDFENAEGNLALAGALLELFSRKLPVSRLQRDLSDSTVLRNLGLAFGYCLLAYQRLLRGLQKVAVDRARLRRDLDAHPEVLAEAIQTILRREGFAEPYELLKSFSRGRALTAEDIARFIDSLLVSDAVRAELQALAPAAYIGLAVKLAQLRDEATVGNWT
The following text describes a protein:
Function:
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
Sequence:
MEVHPISEFASPFEVFKCIERDFKVAGLLESIGGPQYKARYSVIAWSTNGYLKIHDDPVNILNGYLKDLKLADIPGLFKGGMIGYISYDAVRFWEKIRDLKPAAEDWPYAEFFTPDNIIIYDHNEGKVYVNADLSSVGGCGDIGEFKVSFYDESLNKNSYERIVSESLEYIRSGYIFQVVLSRFYRYIFSGDPLRIYYNLRRINPSPYMFYLKFDEKYLIGSSPELLFRVQDNIVETYPIAGTRPRGADQEEDLKLELELMNSEKDKAEHLMLVDLARNDLGKVCVPGTVKVPELMYVEKYSHVQHIVSKVIGTLKKKYNALNVLSATFPAGTVSGAPKPMAMNIIETLEEYKRGPYAGAVGFISADGNAEFAIAIRTAFLNKELLRIHAGAGIVYDSNPESEYFETEHKLKALKTAIGVR
The following text describes a protein:
Function:
Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
Subcellular Localization:
Secreted.
Sequence:
MRTHLYLLLLTVGISATPLRSNLAELQTWLQQIYQSVDMLVSSIFYFCSMNLRIETPVSADDENCIKTLFEGTALLKNNPEMRRFGTFFQSFDKLRPSLTAQLTGEGECDTERKNVKKFIEKLRTFIRKLSRDARV
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).
Sequence:
MSKTVQVYGYPNLESAEVIKTSLENYTGPGTIYALEVKKSNRGSRSYAKVQFKTRERVEYIIDLANNKRLWFGRTYLKAFINDHDIEQRPKQFAFEMEGATVHFGCQVSKETLHVLSKMKNVSVKFGFGLRRLYFVVSYPTTSYKLQLSYENIWQVQLRRSRGNNAKFIVIQLYGAPRIYQKVEDNIHSFYSEVPDDQWVRATDFTPSSSIGQSSHLCLELPLGVDLPNLAHYFPYYEDNHRQFQLVTGQSFSRNLDLVPIVGPTRYLPYNIVFKICTLVQHGCIPGPLLNATFYELLDPQRRDIGSIEYVLEKLFYLKESCYDPVRWITEEYKNNNRLRSPAISLDSGLVYVRRVQITPSKVYFCGPEVNVSNRVLRHYADYIDNFIRVSFLDEELEKLYSTDLSPRANNLTGVNKTAIYTRILSVLKNGIVIGNKKFEFLAFSSSQLRDNSAWMFASTGRINAADIREWMGDFSSIKNVAKYAARLGQSFGSSKESLSVAQHEVAKIADVEVIRNGVRYIFSDGIGKISAEFAKRVSKKCGYDFIPSAFQIRYGGYKGVVAVDPTSTMKLSLRNSMCKFESDNTKLDVLAISKYQPCYMNRQLITLLSTLGVKDHVFEKKQKEVVDLLDAVLREPMKAQEALELMSPGENTNIMKEMLSCGYKPNAEPFLSMMLQVFRATKLLELRTKTRIFVSKGRAMMGCLDETRTLEYGEVFVHFSGAGRRPLNDNGSSSSGGVGGYKSKIVVGKVVVAKNPCLHPGDVRVLKAVNVPSLHHMVDCVVFPQKGHRPHPNECSGSDLDGDIYFVCWDPDLIPPKQIEPMDYTPAPSMQLDHDVTIEEVEEYFTNYIVNDSLGIIANAHTVFADRELEKAMAPPCIELAKLFSIAVDFPKTGVPAEIPANLRVKEYPDFMEKSDKTTYESHNVIGKLFREVKDIAPQNSQVNPFTRDVARQTYDVDLEVSGFEYYVDEAFDFKTEYDYKLGNLMDYYGIKTEAELLSGSIMKMSKSFDRRNDAEAVGLAVKSLRKEARNWFRKGRGDVDVGDDDVYAKASAWYHVTYHPDYWGKYNEDMKTRDHFLSFPWCVHDKLIEIKRSKGRVSRNIDSDWLQQQFSNALNLI
The following text describes a protein:
Function:
Dual function in both nitrogen assimilation and in protection against acid stress during infection. Involved in asparagine uptake.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPPLDITDERLTREDTGYHKGLHSRQLQMIALGGAIGTGLFLGAGGRLASAGPGLFLVYGICGIFVFLILRALGELVLHRPSSGSFVSYAREFYGEKVAFVAGWMYFLNWAMTGIVDTTAIAHYCHYWRAFQPIPQWTLALIALLVVLSMNLISVRLFGELEFWASLIKVIALVTFLIVGTVFLAGRYKIDGQETGVSLWSSHGGIVPTGLLPIVLVTSGVVFAYAAIELVGIAAGETAEPAKIMPRAINSVVLRIACFYVGSTVLLALLLPYTAYKEHVSPFVTFFSKIGIDAAGSVMNLVVLTAALSSLNAGLYSTGRILRSMAINGSGPRFTAPMSKTGVPYGGILLTAGIGLLGIILNAIKPSQAFEIVLHIAATGVIAAWATIVACQLRLHRMANAGQLQRPKFRMPLSPFSGYLTLAFLAGVLILMYFDEQHGPWMIAATVIGVPALIGGWYLVRNRVTAVAHHAIDHTKSVAVVHSADPI
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.
Sequence:
TKVLYASVCDLAARVRALAREKKRREIHKTTYRKTLFIDSERAERTPIERSCQQRALRFRTPQRAIDLHCFNFTPSLCLVMDFESNYDIAASANFIHTHNFIKVALQFPDNLLKHSTRVVTALRNTLQSTEVGLFVMADTAYGSCCIDEVGASHINADCVIHYGHTCFSPTTTLPAFCVFGKASICIADCVESMSKYALTNSKPIMVLFGLEYAHSMQRIKEALLESSMSCRFDPKSEVHFADVPSSVMFPSKDIKKINVLQEPVSDCNGASGTMYSIGGLTWKLPEGQSMDDYLVFWIGHDDSAFANVVLTFNACEIVRYDANENRMVTDLFQHRRILKRRYYLVERAKDANIVGILVGTLGVAGYLHIINQMMELITGAGKKAYTLVMGRPNPAKLANFPECDVFLYVSCAQTALLDSKEYLAPVITPFEAMIAFNRGSQWTGAYVMEFRDLINLPQMGVGNQEEEEARFSFLKGGYVEDFENQACISSENVEEERETLALVNATEKALQLRNNSNVLMKGSARSGAEFLANRSYQGLNMSSENTSPEPYLIGRRGRASGYEDEKNKQ
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 1700 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MISSCVTRCFGRGKCLPGPATASIYQTIRCISTNSNKAAEAPIFPKLEDVKMHELIGNNNFGKKTYYVERSRTGNLPVYSAYKNGGNKIITEIRKIEGDVIQLRNDLQEQLPFIPKKSWSVVMQSKKIIIKGNAVEAVKRVLTKKF
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MAKKNKARLLVKLLSTAGTGFFYVRSRPKAAPKLAFIKYDPKIHKRVLFEESKMK
The following text describes a protein:
Function:
Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
Subcellular Localization:
Cytoplasm.
Domain:
ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.
Sequence:
MEMPKDYNIEIEKQIQKKWEESKIYKFDEESNKPPYIIDTPPPYPTGRLHLGHALNWTYMDIIARYKRMKGFNVLFPQGWDCHGLPTEVKVEEIHGITKSDVDRHKFRELCIELTKENIEKMRRQIKSLGISIDWDKEYITMTPEYIKKSQTAFVRMYKDGLIYRGKFPVNWCPRCQTAIAFAEVEYKERESKLNYIKFPAADGEGHLLIATTRPELMAACVAILVHPEDERYKHLIGKEFIVPLFGHKVKLLADEDVEKEFGTGAVMVCTFGDKTDVLWVNRHKLEIKKAIDEKGELTEIAGKYKGLKTEEAREKIIEDLKKEGYLVKQEPIKQNVGVCWRCKTPIEIIVTEQWFVNVRKLIPKVREVADEIKWIPEHMKIRLLNWIEDMDWDWVISRQRIFATPIPVWYCPKCGNVVVAKEEDLPIDPTKTGYVCDKCGNKDLIPETDVLDTWMDSSITPMVITKWLDDDKFFEKHYPVQLRPQGHDIIRTWAFYTIVKSVALTGKKPWDEIVINGMVFGEDGHKMSKSRGNVVEPDEIIAKYGADALRLWASNSVVGDDVQFLWKEVDYGYRFLRKSWNACRFAKMHISDDIIDELKKPMEISNPIDLWILSKLQRLIERVDKDLENYRFNTIVEIYKFVWHEFCDNYIEMVKYRLYGDDEEAKKEARWTLYYVIDKVVRLLCPFAPHFSDYIAEIYKIDNLHFSFPEVDNRFINEEAEKFGEIAKNTVISIRRFKANSGMALNAPLKYVEIYTEDEETYLALNKTAEDIKGTLKIEELKIIKGKPALESKIVEIIPDKSKIGPEFKKNAKAVMDLIKNADEETLEKIINEGLETEYGVIRKEHIKDVKRALFCEGEEVDSVDIEGVLAMAIIRK
The following text describes a protein:
Function:
Essential protein, may play a role in mRNA production or stability.
Subcellular Localization:
Nucleus.
Sequence:
MSSARDLIKVDIEWGMERLVRAQQVVELRPYDIESWSVMIREAQTRPIHEVRSLYESLVNVFPTTARYWKLYIEMEMRSRYYERVEKLFQRCLVKILNIDLWKLYLTYVKETKSGLSTHKEKMAQAYDFALEKIGMDLHSFSIWQDYIYFLRGVEAVGNYAENQKITAVRRVYQKAVVTPIVGIEQLWKDYIAFEQNINPIISEKMSLERSKDYMNARRVAKELEYHTKGLNRNLPAVPPTLTKEEVKQVELWKRFITYEKSNPLRTEDTALVTRRVMFATEQCLLVLTHHPAVWHQASQFLDTSARVLTEKGVRTSVENISPILCVPVVNQIEWVMAFAWWWAKDVQAAKIFADECANILERSINGVLNRNALLYFAYADFEEGRLKYEKVHTMYNKLLQLPDIDPTLVYVQYMKFARRAEGIKSARSIFKKAREDVRSRYHIFVAAALMEYYCSKDKEIAFRIFELGLKRFGGSPEYVMCYIDYLSHLNEDNNTRVLFERVLSSGGLSPHKSVEVWNRFLEFESNIGDLSSIVKVERRRSAVFENLKEYEGKETAQLVDRYKFLDLYPCTSTELKSIGYAENVGIILNKVGGGAQSQNTGEVETDSEATPPLPRPDFSQMIPFKPRPCAHPGAHPLAGGVFPQPPALAALCATLPPPNSFRGPFVSVELLFDIFMRLNLPDSAPQPNGDNELSPKIFDLAKSVHWIVDTSTYTGVQHSVTAVPPRRRRLLPGGDDSDDELQTAVPPSHDIYRLRQLKRFAKSN
The following text describes a protein:
Function:
Required for replication of Brome mosaic virus (BMV).
Subcellular Localization:
Cytoplasm.
Sequence:
MTLVTPLQFSTVQPNLYRGSYPREINLPFLRTLRLKYILSLTPEPLSTDPLMVKFCEENNIKTIHIKCQSERKADKTKPKIKRKKKTVPIEYDVVVRCVKFLIDKGHYPCYMHCTNGELIISLVVACMRKFSYWSTVSILNEFLVYNSSINIHERNFIENFNSEIEVDDLDIKDKVPWITVRYIARTATESKDELRVDDANASEKVARVSSVSNSLPKLKFHSM
The following text describes a protein:
Function:
Proteolytically removes the C-terminal three residues of farnesylated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MVNYFIISISFFLLEHFYSFYLNFRQSKLLKNLTKVPEYCKDRITQEDFKKSQEYSKAKLDYKTLTSTIQVLTTLLSFYYPVYPYFWNLSLELAEKIGYPNEIIRSCFFFAFTVGVSVITEIPFSYYYQFILEEKFGYNRMTRTLFIKDKIISTLLMIGFGLPILSLAIFIINWSGPQLWFYCWLLLVAITLLSITIYPTFIQPLFNKFTPVDGELAESIFALAKRVGFPASKDTIFVVDNSKRDGHMNAYFYGLFGTKRIVLYDTLVNELDKEELLAVMGHEFGHYKMSHTLKQMLLVQVHLVTLLYAFSLLINDDQLYQQFGFVSSKDSVLVGLTLFMFLYSPIDRIFSLLINIFSRKYEFQADDFAVELGFLNSNHLFKLHFKELGCLVYDPLYSAYHHSHPTLVERSNNIDKKVALYKLKNK
The following text describes a protein:
Function:
Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.
Subcellular Localization:
Cell projection, growth cone. Cell projection, stereocilium. Cytoplasm. Synapse.
Sequence:
MSLHHPVAPPRSRSRVSSGHGSASRTMSANVLRLHESLTNLLNGQDKAHFVHALNDYNSKRNVYTLVHNLMGILNTPEKKQLYVLLGKVIPSSDQTLFWQHVDALCMGASVERPQSVVSNVSPNNVSSMNGSMSRPESRLYQQNTRTIGRPSSSLQSLNHPSNVKQNSETSFQHQNQSYREQNHLQQPHHHHQHLQPGGDELHGKVARKTTDVQLPVEQNRDLKRIVLRKSDQDGGGLGFSIRGGAEHSVGIFVSLVEANSLAEKRGLIKGDQIMQVNDIPFEKVAHSDAVKILKAVNKLVLYVKSVGRVPGSFFSHQTYTWVNPKGRSVSPPPDVDPLGGRMLNDTQNRKSGLNLLKNGDEKKVNVVVNEGESLGLMIRGGKEFGLGIYITGIDTYSVADHAGLKVGDQILDVNSRNFLDIEHQNAVDILKSSKLMMMTIKDVGKLPYGRTTIDRTQWLTGNEVKDSPPTTRPVKRDQVEETDSIYADIPERPSSAFSRGIGSQVMYNKSMAGVQNWSMLEDQSRNLLSENERGTMMYYLEEYQRNTITVEALVMALFELFDTHAKFSLLSEIRAFIFPRDIDRFDGLVLKREVEAMKARQRGYFMNERETSFTDTMSNSSRYNSSSSIDSRPLTPPRIPQHLPPNIRLTNEPEERYRGLDTRQINDDTNGLPDFALPDYAIGSPSSNNNTITPNKNKSLNRSSPSILKSSSLFNPTNGFDSPNLKHVTVDVHHHNHVNQEPSTSGRGVILPGLESMYIGTKSPSEDSGVDVNLTNGLHSLVNLERYKMSDSNDRYHNMTSDTDFSPRSSEESPRSPDSSLEPSPSRVQEEKREASSSQTKDDASDRHSERSGSRQRRMSLDSVSTEGSASVIGELISRQNSGSEHGIPRRISDPTHHTPKDQRRNIDQTKKASETLYELRKSTPTSPHSPTTTSKTTSNQRLSSSSSSSSSQRGAGNGGGRTRPILPPPPPPSAKENSNQSSNPSQSLPYQSVEDLPLPPPPLDFLSAAPFDLPPPLPSPPVNRFPDDAPPLPPTTPPPPPPGFETEDEDEDEVVLPNPSSFPLVATSRAPMSTMSTFKPQGSSTPDKPTPDIIVNTRLDRPPYCEAILVKKTQSNLGLAVEGGSGTRQPLPKIIKVQNGGSAYQSSNLKVGHVILKVNGRPLHDLSHSQSTRVIAEAFKQKSSNTMEFLVLDSNRFKLVY
The following text describes a protein:
Function:
Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTSASAFHFASLVWDWPIAIYLFLIGISAGLVTLAILLRRFHPEAGGSDSTLLRTTLVLGPGAIILGLLILVFHLTRPWTFWKLMFHYSFTSVMSMGVMLFQLYMVVLVLWLAKIFEKEVIALQQRWLPRSGIVQKVLTLIAPFHRALETLMLVLAVLLGAYTGFLLSALKSYPFLNNPILPALFLFSGISSGAAVALIAMALRHRSNPHSTEARFVHRIETPVVWLEIFLLAAFFIGLALGDDGKMRALAAALGGGFWSWWFWLGVVGLGLIIPLLLKPWANRSVTFHGVLAVCGASLTGVLLLRFFILYAGQLTVA
The following text describes a protein:
Function:
Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10. When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Domain:
The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex; The RING-type zinc-finger is degenerated and only coordinates one zinc ions, preventing E3 ubiquitin-protein ligase activity.
Sequence:
MEYLPSLQQEFDELKPSLFELLAEQQLSDLLPPSIRYILAVATHRHPRYLLRVLNSFDEVYALLSLVVERYYLRNFGGSFTENFYSLKRERVLLTKNGEIPRAQLGAPGPVRESLKLRNSDVWKNLLVMVGIPYLKRKLDEGYDIHAAPQASLIMNGGPRYNPSDDLPPHPTIRQRFMHAYKWFLRNVYPSFNAAYYFSILAFNLAYLFDNTKYSSPFLWLIGTRIRRLSSADHQAIAKILEGKPQTPNSRSARSRPGSGLLGLFSPHNLYPQLLTSLRYFLPASIFALKFLEWWHASDFSRQLARKATDTLDIPAPITKGMISPSERKSRPPTKQKEDPESPKSALKTSSPHKRIQPPISASSYLPIFTVPLPPADSDAASSCPVCLNQLTNPTACQTGYVYCYVCIFHWLNGEHQRQIDFMNGDGAGAAWEDDSGDGIDADGDRNETESAAKTGKSRHGKWESGKGRCPVTGRRVLGGTEGLRRVLI