lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAARLPCERSYLVSAPGKAIIFGEHAVVYGKSAIAASIDLRTTATIRPISDFITLSLPDLDFVFKWSVLLFNEIPHATLLPLKIQHDSLNMMMSMLPATCSEVVKQSASAFLTLYTQICHVRSGFHLDVTSALPIGAGLGSSASFSVCVASLLLLFSGTIQMPITATDQFSSHDLNLINNWAFISEKVIHGNPSGVDNSLCTFVCQAYFKSLVGGARVYTKLEGIQELKGFPQLEFILTNTTVPKSTKHEVEKVRLRREKFPYIVNSLLDSIQAISDCCTSACLKNDQNTITLLDLIEQFEVLVDMNQSILVGLGVSHPKLELIRLITSQHGHRSKLTGAGGGGCALTIIRPGTTEKDISTLCDALECEGFQCFRAQVGCKGVQACLIE
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MTAKIDLLTLQLFVAIVEEQSIAKAAEKKNIAASAVSRRISDIEDRFQVELLHRHSKGIEPTPAGFALLEHARIVLGNLSRLETELTGYRQGKRGLIRVCANKSAILEALADELSLFLERHPLVHIDIEEDLSPAIVRAVMENRADIGIFGGNIDAQDLELLSYRSDSLVALVTRDHPLAGRSSVRFRELVDFDFVSLEKGSSIETLCVRAAAALGQHLKVRIRVSSFDALFRVIDARMGVGVVPLEIVRGRYGVDSLVTVPLDESWARRELVMGVRDYKSLPPVTKLLVDHLRTQDDTGLTTSSVSDRLTVVRSRG
The following text describes a protein:
Function:
Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Late endosome membrane. Membrane; Multi-pass membrane protein.
Sequence:
MLKCVLVVNLEATVVLLGLTLLSLSFCGCVGALRENTCLLLTYSYFITALLLLNLALGVLVFFLPTQLKRMLRSTLTRNLVVHYRDSADLQKLIDSVQVELQCCGISQKDFRDWNDNMYFNCSRSNPSSERCSVPYSCCKKNSSEQVVSLYCGQGVLNQTDYDAWFKIYTGNCVDAGHRFVRENVTLITGLCLVFVILLAFVQMVTQALVDEIIIIRRIYDRFYDRVFELRAADVTD
The following text describes a protein:
Function:
Acts as a critical meiotic inducer by binding non-covalently to protein kinase ran1/pat1 inhibiting its enzymatic activity. Inhibits ran1/pat1 by acting as a pseudosubstrate for ran1/pat1 instead of its natural substrate ste11. Inactivation of the ran1/pat1 protein kinase is both necessary and sufficient to divert a vegetative cell from mitotic division to meiotic differentiation.
Sequence:
MSSQNTSNSRHPASSASALPNRTNTARRSTSPRTSTGSSSTNTNTKTVDHAGTTFISSTSKRGRSTKAGSVHSVPMKRTKRVRRTPAQRIEHENKENIQTEKVYRIKPVQRVLSPSDLTNELTILDLFHVPRPNETFDITDRVNNTSR
The following text describes a protein:
Function:
Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSQLANPELMKVVILLASSVTIVPLFKRLGLGSVLGYLVAGCLIGPSVFGIVQEPTAVVHLAELGVVMFLFIIGLEMYPERLWAMRKAIFGRGLLQVGLCGCLLTFSGIYLLGLTKEVSFIAGMGFTLSSTAIVMQSLEERGLTSTSKGQRVISTLIFEDIAIVPLLASVAFLAPHSKEATPHTDWVSIGIALSAVVGLIVTGKWLMNPLFRLISKARIREMMTAGALLVVLGAALAMEIGGLSMAMGAFVAGVMMSESAFRHQLEADIEPFRGLLLGLFFMGVGMSLDLHLVFNHWILLLGIVFLYILGKASAVYIIARITRLDHREAIGRMSLMAHGGEFAFVLFSAAATAEVISNEEQATFTAAVIISMLFSPIIAQIARKLIQRTEPKHLDQLDENDLDTIVDLEDNVLVIGFGRFSQIVCQTLLIRGISVSVIDRNIENIRAAAKFGFKVYYGDGIRLDVLRAAGIEKAKCVVLGINDTQRIEHIVSQMKEAYPNLPILTRTYDRKTTVSLIKQDVDFIVRETFESAITLSRATLMKLGIDKIEAEEIIKEVRTLDQERLNEEVLHGFSNEIVKKYWTPRPFIKPHLDTKALNKETEEILSEKIEEEISNDHS
The following text describes a protein:
Function:
Negatively regulates mel-11 to relieve the inhibition of mlc-4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization.
Subcellular Localization:
Cleavage furrow. Cytoplasm, cytoskeleton.
Sequence:
MEESLVRELIDPRSPLNVESLLDAVTALVDDCNHPVLRRIKNIDSFVSRYECLARRLNEGRLKGSDFQLVKVIGRGSFGEVQLVRHTRTRQVHAMKLLNKYDMIKRSDSAFFWEERDIMMMANSNWIVKLHYAFQDTRYLYMVMEYMPGGDLVYLMATYDVSEKWARFYTAELVEALSTLHGLGFIHRDVKPDNMLIGKNGHIKLADFGTCVRMSKDGVVKCSTAVGTPDYIAPEVLRNQGHDHEYGREVDWWSVGVFVYEMLVGETPFYADALVNTYTNIMNHRDTLQFPDDGPPMSCHSKNLIRLLLSDADERLGRNGADEVREHAFFRNEDWTWESLPTAVPPFVPDLRADDDASNFEVDEQIDQGETFQIPRAFTGNQLPFIGFTYSNEYSPAEQLKNVLAEGGGEESRRSTRRIEEKESMEARCAELEDMIERSRRELGESINREKKARIDIESLQDSLNETESMCKRLKEEKDEVMKMKEERKSEQIGIMEEKLLKKEDEVKDLKSKLSGLEQKINVAREEEAKRDMEVRSIHAKLAKEKESNRQIERRLREVEATNDSMLVKIEDAAIREDELTKRLKKAHDEFKENGGLTESRRLNELERERNHEMQLKMDDLHASLQREKWNCEKMKKELDEAHVNLAGFEGKEKCLEEEISKIREKVHTLERSCESLKVTNRELERECLSLTSKLETESSLNKLYEGVARDLKDEQEMNERGKREIDKLISHLESEKLARHIAETSMNDLDKEKTMLKEEVRQLGMRHDKELQKKKTIIDQLSAKEKALEESLICLRGEKGRREDREDREGTHEKNALIEELKKRLATAELVKKSAVNKLEEMVAKRVPEKGGHKNNLKAELKKKERDISTMQQRISDLERQLSRAVEEKNLELAEMINNLQEESTKRETLEKEIMEMNETREEIDRRRGINSGGMSIPMSIPSCESISPLHIDPLEGYLSLRIESGKKGRKSNHDWSNVFASMNHLHLRLFADDKSYNEGISMLSIEAHQLVLARFVTSADIRSASNATLPKIFHVMYETNEEGSSRTNSLIDLNTSSLTFSHMSVKDHQERERWNRHDFCELTYHVTTSCDLCMKKLSATLRPPPALECKNCHLKIHKDHVSNLEIPVCKFKTGVRQMLLMADSAHLCQQWVNNLMTMKKMWEKMRPVKSSLSRHSTIHTGDNHSPRNSYHHH
The following text describes a protein:
Function:
Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MGSIFKDGRRILVRPKSLIICLCLISIIFTQLIRYQYQLIADEVQPTINEDHSSSQSLKNTKLNSTRSSSPISPPKSLNKLTSQEFWEHIFNIFEINKFDDGLKPLIKYTPKEQQLTTKIKTRDWLLSKANIFHKDIIRQYHESVLRNLPSKLPKSVYTPNTYGIVTIGGNFYSWMAYIQLLQLRKLGSNLPVEILIPSIEDYYKEAHFCDHVLPQYNAKCILVPEKLGFNVAKHWKFSSYQFKALALCLSSFQHVLILDSDNVVLSKPEKVFDSPVYRDNGMVLWPDYWERTISPEWYDIIGKPVVGNKQVRTGRFPVNIHNMLTSELEINETRFHDLEGALPDLSTESGQVMFNKKTHGKVMLMTLYYNIFGPEIYYKLFSLGALGEGDKDTFAAAALACGEKYYQVASSIRTLGYFDTTPGGGFHGMAMAQKNPQLDYQLFQKTNQNFKDLHLDWDNEAKDQFSANNKIPIFTMHCNIKKINPAAYMKDEKIANMDEKRMNVRFYSNLKFKLNDDDIYSPDNEKEKNKSEKTDNDPNEIDFELSRWQIVSEILCDQKITFQFLKDENMDEVCQFVKNTIAWLGKKT
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAQASLLACEGLAGVSLVPTAASKKMMLSQIAGKQAENGERAGSPDVLRCSSQGHRKDSDKSRSRKDDDSLSEPSHSKKTVKKVVVVEQNGSFQVKIPKNFVCEHCFGAFRSSYHLKRHILIHTGEKPFECDICDMRFIQKYHLERHKRVHSGEKPYQCERCHQCFSRTDRLLRHKRMCQGCQSKTSDGQFSL
The following text describes a protein:
Function:
Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process. Together with the SufBCD complex, it thereby enhances up to 50-fold, the cysteine desulfurase activity of SufS. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Does not affect the selenocysteine lyase activity of SufS.
Subcellular Localization:
Cytoplasm.
Sequence:
MALLPDKEKLLRNFLRCANWEEKYLYIIELGQRLPELRDEDRSPQNSIQGCQSQVWIVMRQNAQGIIELQGDSDAAIVKGLIAVVFILYDQMTPQDIVNFDVRPWFEKMALTQHLTPSRSQGLEAMIRAIRAKAAALS
The following text describes a protein:
Function:
Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.
Sequence:
MSDNSDNVLTQSTGCPVDDNQNSLTAGEYGPILLQDTHLIDKLAHFDRERIPERVVHAKGAGAYGYFEVTGDVTKYTKAKFLDTVGKRTPIFTRFSTVGGEKGSADSERDPRGFAVKFYTEEGNYDMTGNNTPVFFIRDPKILKLTQRMLIQFWDFLSLVPESAHQVTILFSNRGTPNGYRHMNGYTSHTFRWVNKEGEAFWIKLHFKTDSGNKTFTGAEADELKRTNADYATQTATWTVQVQVMPEQDGFKYKWNIFDVTKVWPHSDYPCLNFGKMVLNRNPENYFQEVEQSAFSPGHLVPGIEPSLDKMLQGRLFSYPDTHRHRLGTNYTQLPVNCPYRARVINQQRDGPQSYNNQGNRPNYEPNSFQPLKMIPETKTSQYRVTGLIGRYKPSHPNDDFAQPGVLYRKVMNDFERQWLITNIVGNLKNANRVIQERQVKVFTKCDPEYGEKIAQGLGFPNNKARL
The following text describes a protein:
Function:
Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides in xyloglucan degradation, converting 'L' units to 'X' units.
Miscellaneous:
MISCELLANEOUS: Gut bacteria supply the human body with energy from dietary polysaccharides through glycosidases that are absent in the human genome. Xyloglucans are a ubiquitous family of highly branched plant cell wall polysaccharides present in the vegetables we consume. Enzymes involved in xyloglucan degradation mediate the conversion of otherwise indigestible plant polysaccharides to short-chain fatty acids.
Subcellular Localization:
Cell inner membrane; Lipid-anchor. Note=Cell inner membrane localization is predicted by analogy with the archetypal sus locus.
Sequence:
MMIGKLKYLMLGGCLILGSCLALGGCLMLLGACSSSSLVSPRERSDFNADWRFHLGDGLQAAQPGFADNDWRVLDLPHDWAIEGDFSQENPSGTGGGALPGGVGWYRKTFSVDKADAGKIFRIEFDGVYMNSEVFINGVSLGVRPYGYISFSYDLTPYLKWDEPNVLAVRVDNAEQPNSRWYSGCGIYRNVWLSKTGPIHVGGWGTYVTTSSVDEKQAVLNLATTLVNESDTNENVTVCSSLQDAEGREVAETRSSGEAEAGKEVVFTQQLTVKQPQLWDIDTPYLYTLVTKVMRNEECMDRYTTPVGIRTFSLDARKGFTLNGRQTKINGVCMHHDLGCLGAAVNTRAIERHLQILKEMGCNGIRCSHNPPAPELLDLCDRMGFIVMDEAFDMWRKKKTAHDYARYFNEWHERDLNDFILRDRNHPSVFMWSIGNEVLEQWSDAKADTLSLEEANLILNFGHSSEMLAKEGEESVNSLLTKKLVSFVKGLDPTRPVTAGCNEPNSGNHLFRSGVLDVIGYNYHNKDIPNVPANFPDKPFIITESNSALMTRGYYRMPSDRMFIWPKRWDKSFADSTFACSSYENCHVPWGNTHEESLKLVRDNDFISGQYVWTGFDYIGEPTPYGWPARSSYFGIVDLAGFPKDVYYLYQSEWTDKQVLHLFPHWNWTPGQEIDMWCYYNQADEVELFVNGKSQGVKRKDLDNLHVAWRVKFEPGTVKVIARESGKVVAEKEICTAGKPAEIRLTPDRSILTADGKDLCFVTVEVLDEKGNLCPDADNLVNFTVQGNGFIAGVDNGNPVSMERFKDEKRKAFYGKCLVVIQNDGKPGKAKLTATSEGLRQAVLKISAEEL
The following text describes a protein:
Function:
ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress. Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37. In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein. Nucleus.
Sequence:
MKRVRTEQIQMAVSCYLKRRQYVDSEGPLKQGLRLSQTPEEMAANLTVQSESGCANIVSAAPCQAEPQQYEVQFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLHMVQNGLKSTVDSFYSRFHGMFLQNASQKDVIEQLQTTLTIQDILSNFRLRAFLDNKYVVRLQEDSYNYLIRYLQSDNNSALCKVLTLHIHLDVQPAKRTDYQLYASGSSSRSESNGLEPADMPTSILQNEAALDVLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDNKLLAAGFDNSCVKLWSLRSKKLKSEPHQVDVSRIRLACDVLDEEEDDDDNVGTEMKILRGHCGPVYSTRFLSDSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPCSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSTQQGNSVRLFTGHRGPVLSLAFSPNAAVGFLTVSSVVTMSAPFFLGKIIDVIYTSPTGDHVNSLTQLCVFLSGVFLCGAAANAVRVYLMQTSGQRIVNRLRGNLFSSVLKQEVAFFDKTRTGELINRLSSDTALLGRSITENLSDGLRAGAQASVGIGMMFFVSPNLATFVLGVVPPISIKAVIYGRYLRKLTKMTQDSLAQATELAEERIGNIRTVRAFGKELIEIEKYTSKVDHVMQLAKKEAFARAGFFGAAGLSGNLIVLSVLYKGGLLMGSAHMTVGELSTFLMYAFWVGMSIGGLSSFYSELMKGLGAGGRLWELLERKPVLPFNEGVVLNEETFQGALEFKGVNFAYPARPEVKIFQDFSLSIPSGSITALVGPSGSGKSTVVTLLLRLYDPVSGTISIDGQDIRQLNPAWLRSKIGTVSQEPILFSCSIAENIAYGADDPSLVTPEQIQKVADIANAATFINSFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPRILLLDEATSALDAENEYLVQEALDRLMEGRTVLIIAHRLSTIKNANMVAVLDQGKITECGKHEELLSNPDGLYRKLMKKQSFISA
The following text describes a protein:
Function:
Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3).
Subcellular Localization:
Nucleus.
Sequence:
MPLGLKPTCSMCKTTSSSMWKKSPQGEILCHHCTGRGGGGAGVAGGTGGGGGGGGGFGTTTFATTSAGPSQSNGGGGGKQSKQEIHRRSARLRNTKYKSAPAAEKKVSTKGKGRRHIFKLKNPIKAPESVSTIVTAESIFYKGVYYQIGDVVSVIDEQDGKPYYAQIRGFIQDQYCEKSAALTWLIPTLASPRDQFDPASYIIGPEEDLPRKMEYLEFVCHAPSEYFKSRSSPFPTVPTRPEKGYIWTHVGPTPAITIKETVANHL
The following text describes a protein:
Function:
Involved in the degradation of 2,4-dinitroanisole (DNAN), an insensitive munition ingredient used in explosive formulations as a replacement for 2,4,6-trinitrotoluene (TNT). Catalyzes the removal of the methyl group from 2,4-dinitroanisole (DNAN) to yield 2,4-dinitrophenol (2,4-DNP) and methanol.
Miscellaneous:
MISCELLANEOUS: Unlike other known O-demethylases, it does not require oxygen or electron donors.
Sequence:
MSVTSQTSSSGSAAVSDCHRGIIDISGPVPGYEWEPSMTTEPVRGRVWTITDGVFRTLAIEGDTGVIAVDTFWSPGSARQYRRALQSHFPRKPVHTIIYTHDHLDHTGFGADFAPDADQILAHELTAEVIARRSSDGQLPATRTWSGERLEVSIDGAEFELIYPGPTHGTGNTALYFPNERFLYMADTVFTGPTYNIVPDFLWTSWIPNTRRLLGLDWDLYVPGHFWRLSRREFEADFELWDATAACALDALRAGVDIDNFADVKKFTYERMDEPFGSRTFRFDEFAAINVLTHMVHYQTGGWGLRDYEPYSNEPFKTTLPQRLGSPL
The following text describes a protein:
Function:
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDKNTITGLVLIGILLVGFSYLSRPSEEQIAAQKKYYDSIAVVQQQQEALKAKTEAALANENKGAAAAADSSALFFNAMHGTDSKVSIQNSVAEITFTTKGGRVYSAMLKEYKGQDKTNPVVLFDGDDATMSFNFYNKQGAIQTKDYYFEAVNKTDSSVTMRLAADNASYIDFIYTLKPNSYLMNFEIKATGMEGKLASTEYVDIDWTQRARQLEKGFTYENRLSELTYKVKGDNVDNLSAAKDDEKDLGNTAIDWVAFKNQFFSSVFIADQDFNKVSVKSRMEQQGSGYIKDYSAEMSTFFDPSGKQPTEMYFYFGPNHFKTLKALDKGRTEKWELNRLVYLGWPLIRWINQFITINVFDWLSGWGLSMGIVLLILTIMVKVVVYPATWKTYMSSAKMRVLKPKIDEINKKYPKQEDAMKKQQEVMSLYSQYGVSPMGGCLPMLLQFPILMALFMFVPSAIELRQQSFLWADDLSTYDAFITFPFHIPFLGNHLSLFCLLMTVTNILNTKYTMTMQDTGAQPQMAAMKWMMYLMPIMFLFVLNDYPSGLNYYYFVSTLISVGTMILLRKTTDETKLLAILEAKKKDPKQMKKTGFAARLEAMQKQQEQLQQQKQNKR
The following text describes a protein:
Function:
Probable tyrosine-protein kinase receptor which regulates the dauer/non-dauer developmental decision probably by controlling daf-3 transcriptional activity in parallel or together with the TGF-beta pathway. Regulates integration of conflicting sensory cues in AIA interneurons. May act as a receptor for hen-1. In AWA neurons, together with hen-1, plays a role in regulating olfactory adaptation by controlling the forgetting sensory responses to odorants such as diacetyl.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRKRRLWWFVVLFRVTLVGAILPNETFDVRRYYADRFLIEDEENGSSRSYYISAESKAKAAEQFALLAPNCSLTSDIQENTCNETSSFCDHRVDSTYKTYHYEQEKCNCFIETCDEETNSTELMVLYPDCYCGKREKHCDLSKEKCHWTPDSDHDDLKFEVFESSNKVLFDYMLQAGSEKANLKMNKVSMVSKFFRQSGFNCSLRFMHHFTHQSSTSRLVVRSILQSGEKKNLYEHWLKPASVFWVPVQVAIGSYAEPFKISIDCETGFPPKKKKNKPFTCSIADIYFENCGEIRDPIEQCSRGDQFLCSISANTRCLQNAQCDSRIDCDDESDEMDCGNINGTMCDFNGQDYCNSWYQVTNVTDYHERLSEPTTVAPLNKLNEVPLHLFRLQSPSAKIKEAMRGSGNMLVFDHKPNPLTRRTSALVSPELPRTNPEAYDEKSPLFKSCKLRFYLCSRTYSKVWQISVISKGINPMESGRTIIYEAGYTLIPKENCTWERVFVNIPRQNAGFRIGIFVTNYFPGSEEYVAIDNLSFSPTCFERDINQSTWDIPDLFINTCGASGFEQPQNCDHNRELDGQTGHFLKEDGTQQWTVPVTGFYRMEICGAGGGSNSKASGDTGDCVTLQVHLIENLSLRMLIGQMGESPCFTEHDDELRPSSCSKISHNYVYDGKRGAAGGGATLLTVEKDLWNVVAGGGAGASWDGFDMEVGYGASAIHVKPDQRCNETCKAVSHTDFIVERRDNRCPGEKGESTVFGGFGGGGNSCGMLGGSGAGYQAGNPFGKSRARSGSSNVSIDFSKSPIYYQSERLDEGYIKIAFCRKRCEPPTVCRFRKDYFEEEYCGCPDGSNVTDTEEACAFPLVCPSSSTNQYRNFTYEPFCLCNNGKEIYDVYNDTCEEIQIWTLYNITFLIFAALTIIGALFVVYHYRNREKQMKQEILDLTQMKSPDYLYDDIYFGRTTRKAALDSLPSISRDSIERGRVLGRGNFGEVYYGEYSGVKLAVKMISRTFSASQASQSDFCNEALCMGTFVDENVVRLIGIDFEKVPYMIALEYMEGGDLLSFVKECRPNQVSLNPFQLAMSDLIKICCDVAAGCKCLETFGYVHRDIAARNILLTTRGPQRVAKIADFGMAKEITYGTEYYRINGRTMMPIKWTPPEAFIDGVFTTKSDIWSFGVLCWEVFSLGVVPYPNRRNEEVMLMLTEGARLEYPYGIPTRVYQLMRDCWKTAAADRPKFVDVVEIFQDIQDDPASVGMPFPIHPAVRATFAHSQSTPVSVETPMTAMTEISLNSTFTDASTVKVSAQQDMQDRIQLHELMLTREHPYTSELTSYVVNSIRKDLARVQYENGLTSVPQPEYLSPENNDESVQLIPQSNTVTDQTPPTSLIDLNRLGVQNTGPTLHRPDSLNFNDPYSSVPLLECQTR
The following text describes a protein:
Function:
Catalyzes the hydrolysis of alpha-D-ribose 1-methylphosphonate triphosphate (RPnTP) to form alpha-D-ribose 1-methylphosphonate phosphate (PRPn) and diphosphate.
Miscellaneous:
MISCELLANEOUS: The sequence shown is that of strain K12.
Sequence:
MIINNVKLVLENEVVSGSLEVQNGEIRAFAESQSRLPEAMDGEGGWLLPGLIELHTDNLDKFFTPRPKVDWPAHSAMSSHDALMVASGITTVLDAVAIGDVRDGGDRLENLEKMINAIEETQKRGVNRAEHRLHLRCELPHHTTLPLFEKLVQREPVTLVSLMDHSPGQRQFANREKYREYYQGKYSLTDAQMQQYEEEQLALAARWSQPNRESIAALCRARKIALASHDDATHAHVAESHQLGSVIAEFPTTFEAAEASRKHGMNVLMGAPNIVRGGSHSGNVAASELAQLGLLDILSSDYYPASLLDAAFRVADDQSNRFTLPQAVKLVTKNPAQALNLQDRGVIGEGKRADLVLAHRKDNHIHIDHVWRQGKRVF
The following text describes a protein:
Function:
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAKKSVSVIAAKTAVHAAVLAPIALLGWQFWQVWQQGSDALGADPVAEIEHRTGLWALRLLLITLAITPLRQLTGQAVLIRFRRMLGLYAFFYASVHLTAYLWLDLRGFWTQIFEEIVKRPYITVGFTAWLLLVPLAITSTQGWMRRLKRNWGRLHMLIYPIGLLAVLHFWWLVKSDIREPALYAGILALLLGWRVWKRLSARRTTARHSAPPPATPR
The following text describes a protein:
Function:
May be involved in DNA replication and thus regulate cell proliferation.
Sequence:
VKVENKAWKAGSRTIDIELTTLSSTNHIKLSPSDAGFQDRYIVQEIIKEMAKNRPIDTKGKKGYKVLVLNEVDKLSREAQHSLRRTMEKYNAYCRLVLCCNSSSKVTEAIRSRCLNVRINAPTEEQIMKVLEFIGKKEGLQLPYGFAARIAETSNRSLRGAILSLETCRVQQYPFTSNQAIPPMDWEEYVSEIASDVMKEQSPKRLYQVRQKLYELLLNCIPPEIILKRLLYELLKKLDAELKHEVCHWAAYYEHRMRLGQKAIFHLEGTFMFLDVG
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MPPKEESSKVTRRSTRSSASVTVENSEPIESHTPTIDDLTFGEESITIDAVLSNFPGRRSQIFDFIRLMGPLDCPTLPIMIYGGASTGKTSVVLQVLRHLNRPFVYSSCRTCYNPRILFESILNQSLLHRKCSLNGYSSAKRCDKPSDFVNLLREALSSVIKTLESTSETSRSDKPDEKPMGKMVYLILDNVDLIRDWDKGTIILQFLFSLYTVLKMPQLGIILISGLPPDVYYSNMGYTDPIPLYFPEYSEEDLRQIFLRNQPNRKLYSAFLDVVLKPFCRVTRRVEELSTTFSLLFRKFCEPLDDLGISPNEDMKRRLYSHLKPLIAHCLNEIFRVSSHPHDGETRGERRQKASYSSENREELEILDFHMSTSAKFLLLSAFLASRNPATLDASMFDSTGGMDNRKRKRKASEKSMEKKEIAEQEAVMKGPGSFPLERLLAIFQCIASVGDSSFGEEDEEEENTTGYDKENNNLMSDILLQVSSLCDANFLIKSGSCPLEGSIRYRSMVSEDLAQKVAKSLSFPLSKYLYRR
The following text describes a protein:
Function:
As a member of the SWAP1-SFPS-RRC1 splicing factor complex, modulates photomorphogenesis by regulating the gene expression and pre-messenger RNA (mRNA) alternative splicing of a large number of genes, including those involved in plant responses to light signaling. Involved in calcium homeostasis, growth and proliferation (By similarity).
Subcellular Localization:
Nucleus. Nucleus speckle. Note=Colocalizes in nuclear speckles with U2AF35A, U2AF35B and U2A'. Observed in subnuclear light-induced structures called photobodies.
Sequence:
MDRRQHDYAASSGLPYAQQQQQQGPNFQQQQQPQFGFHPQHPQYPSPMNASGFIPPHPSMQQFPYQHPMHQQQQPQHLPHPPHPQMFGQQQPQAFLPHLPPHHLPPPFPGPYDSAPPPPPPADPELQKRIDKLVEYSVKNGPEFEAMMRDRQKDNPDYAFLFGGEGHGYYRYKHFLSMHPPGGPFDPPFPSSSMPMIHHPPNPMMSPSMNNVPGALAVPPIRQPPFPPFHDHHQLQQHLPQPHPFAPHARPDFDQSTHAFRGLSGPLPADVAMELNGVLGNLNGTKESIKSAKIWFMQRSPFAPALAEALRDRVFAMDDSDRQMHIVYLANDILFDSLQRRTNLHEFDNEALAFRPILGSMLGRIYHFPQNKEENQSRLEKILQFWASKEVFDQDTISSLEKEMKSGPPANTFSHSPIIAAHALQRPGMLQQPPNSNVSSTMNLEHLTNPVATQQFIPNVMPPGAFPGSIPLNASVPPPTQPPAGEKPPPYPLFPPGLIPGMVRKMQIGSGVPYSPLSPLDIPTVIPPSDTPQSEVLERVSKFFKEIGEVNPSEGPMGSESQDDYDNYERDSPQRKGGACIPPPPNLQVDPETGTYADGSTDKKSGSGRLGLGATADPNEPTQYDDVYTSYRKHRSTNYHTSMSARATTR
The following text describes a protein:
Function:
Proteolytically removes the C-terminal three residues of farnesylated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MFPYWTSIIVLTILTTLFELYKHYRQHKLYYIKEIPTDVKEVYGDSIEQKEFEKSQNYHLELSKVSFIRLTISFIINMYVLCSPILRIIWDFSTIYNQFLTSIIFIIIFDFISTIISIPFKLYTTFIIREKYGMNNMSLIVFIKDFIKSFILETILNLIIITLLYFVSETQNLALYLWFGIMTLNIIISLIFVPFVIPLFYKKTPLQEDQYKNEIESKLNEVNFPLKSVSVIDASSKAKEGNAFFSGLFGKRDLVLFDTLITTCSSDELVDIVLHEVGHCKHYHIFKLLGIQSIQFFIIFKFIEFFLLDEALYTQFGFDQKVVVVGFILLQSLLEPFMEIVSLGINFISRNFEYQADVYATKHGNHQLASALIKLQKNNLSAYVVDPFVSTIENSHPNLVERIQAINKIIKDMKSD
The following text describes a protein:
Function:
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
Subcellular Localization:
Cytoplasm.
Sequence:
MNKLNEALKKAERIVFLTGAGVSVPSGIPDYRSKNGLYAGMSSPEYMLSHTCLVREPEKFYQFVTENMYYPNAVPNVIHKKMAEIETEKDVTIITQNIDGLHEKAGSKKVVNFHGSLYHCYCQNCGMTVTAKDYLKSDIHTDCGGVIRPDVVLYEEAISESAIDQSLTAIRKADLIVIVGTSFRVSPFCNLTDYRNKKARIFAVNKERISLPYPFEMMESDAVKVFEEI
The following text describes a protein:
Function:
Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding sites inhibiting cell growth (By similarity). Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.
Subcellular Localization:
Nucleus.
Sequence:
MHSPGSTGPGDGRAADIMDICESILERKRHDSERSTCSVLEQTDIEAVEALVCMSSWGQRSQMRPLTPVSDSGDVTTAVLMDTAAPDLPKDFHSFSTLCITPPQSPELTEPSTGTPVPSQVVNSKGCMVTALPPSPAGGPRTLSKREPLEPASGSSCRAVMTSVIRHTGESPAPTRFPTGPTQEQRASDSGEGQERLLDHLEALQDTRLANGLLVTNLVSCQPCLHKSGGSFPTDKGQQTGWPAAVQTCLPKNPESDLSRKITPLISVPVSSPPVLCQMIPVAGQNGLFSAFLKPPTQLPAGTIKPILPQAASMSQPVFMGPPVPQGTVMLVLPQNTFPQPAACPSSVMAIGNTKLLPLAPAPVFLASSQNCAPQVDFSRRRNYVCNFPGCRKTYFKSSHLKAHLRTHTGEKPFTCSWDGCDKKFARSDELSRHRRTHTGEKKFVCPVCDRRFMRSDHLTKHARRHMTTKKIPGWQAEVGKLNRITLAESPGSILEPLPASG
The following text describes a protein:
Function:
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis, especially in strains lacking other exoribonucleases; A general regulator of small RNAs (sRNA), contributes to their degradation. Upon overexpression suppresses sRNA-mediated RhyB-silencing of multiple RNA targets; overexpression leads to nearly complete loss of RhyB sRNA.
Miscellaneous:
MISCELLANEOUS: Member of the DEDD group of RNAses that are characterized by the presence of four acidic residues in the active site. These residues are conserved even when the proteins have highly divergent sequences.
Sequence:
MSDNAQLTGLCDRFRGFYPVVIDVETAGFNAKTDALLEIAAITLKMDEQGWLMPDTTLHFHVEPFVGANLQPEALAFNGIDPNDPDRGAVSEYEALHEIFKVVRKGIKASGCNRAIMVAHNANFDHSFMMAAAERASLKRNPFHPFATFDTAALAGLALGQTVLSKACQTAGMDFDSTQAHSALYDTERTAVLFCEIVNRWKRLGGWPLSAAEEV