lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MIESVWSIKIMEGVSEDFYDSGPTFQYPNPLSSIYDKSMNIDLMNHYHPSTSLITNSNNPFYESLSDTSSDDLNNEDNSNSNNNQNNNNNNNNNNNNNNQNSNNKLLGIEKQLQSINLLTNKVDWSDYHQQVYHGCSNENSQLISWSVDNQIAFTMNFNKNQFIKQEQQQIYITRVEYPHEYVVIKTSHTNSIKCLEWSTQSPSNLLLSFDQSDKLCLWKTKDNCSDDWYCLHIFPFQYLLLSKWLPLRSTYTPIFDPFNLNNTNNNNNNTTNINNNNNNNSNNSNTSTNTFKSPFESLITDNHIDNSFQTFISITKDGKIYIGYYGIVESCWKYIIGQIPLPFYHTIDCVDIFPTQEPDSLLVTIYSKNIGLALIVYHINYNIHTSEVTVTLKDKISMSNIIEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQDVDIRSLSFRISSIQFDNSMSSLIVLMKGIDSSAIYRLEKKLISIDSPQLSIFELLSGTAPNETNQEIEEWTCTAKRLFYTPNNNNSNNNSNSNNNNNSGNNFNHYSTISSIYFSSTTGFLWLTHSNGSIEIVDRLTFESISTLKESEKPIDNIIISSNLNNENSEQSIMNSPTISGSTSPILQSTKANSPHSIKDDSMVIDPSNPTSTSTTTSSTTSQIQEQDNNNNNNNNNNFLPSTKNTTLSITSSPNGGLIACLNSDLKVTLYSLPIKSIGTSPDNQKVVSKWLAQLFQNSMLKSNDWWDILILLKIYSTSPDTRTTFHHTIIHLSSDFSCLPLTFQQTYRHCFDAIKASIYRIVSGMEVAFVDSQAKSFIYYLCDTLKSSFSPLLMQPSQQSDGTTNQQTLKERENIIILIDWAIEFSQFFLKNCYYFSFVYAKKGDISVKIPESMLDLPIKHYFPFYYSETKGNFHFPIISFLCDFNLLFVIFELMNISKLFKEKTSTSQSKVKFKKSKEIDFFLEYFTKIIKVLCKEVVSSSSSSNNNNPDEINNTLGLIDTYLSTFYGFLSEDKLDQVITPPAIECKGSHMNSIIAIMKKFDSIIPSEVIADTNDISINISYSILDLDPPLDGFLDQNPITSSSLSTIQQQQQQQQLGNSSNNNNYNNNNNNDTSGNGSVIFKYSPKSTEYMGIVHDIITRIPIAPRIDKPYKKCIRCHRITVMLRTSMFWSDRWSMACPICGGKWKSYQSSSSSYSSSSNTHDIANNFNSNFYNNNYSSNNFNSNYYNSNNNNNYNNNNYNNNKYYFNNSNNNKINKHLNKTNKHLNNIHRHHNHILINRT
The following text describes a protein:
Function:
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of the phytotoxin stemphyloxin II.
Subcellular Localization:
Nucleus.
Sequence:
MSTISFFATSKRTSCDRCRKQKLRCPPDKDDMGTCGRCLRAGVACATSYTKPRGRSQKHGISTDGTSHVSGLDMQEPALPTPESVLSAGLTSSVQVAEDGSQLWSPLEEYNHLPSLSNFESGALSQSQDEDFAGLWWSPLHEDLDLDVHMDPSGACQNGYSAEISSFSRTDCSRQSNDCSPETLQHVECDMRLSQLNLELCRQSKAYHHWPNTTSDGSVRRPHFAIASALRDLLQNTEAFIHILHCLRNGTELNLDGRYQEPISTHDTGVSPPSLAFPSILNLTSCFFRIVDLFNVLLSSLALELATHSPLQRRSSSSSVTSALQILPDLKLAGLAVQEVSLQTKILVLTITHHFETMERLLGLPADLRVSECKDDNGYGLLGASWTSVLSSGRREKFELGWRRTGNWVTSIESLKANMGTLTKGSC
The following text describes a protein:
Function:
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
Sequence:
MPMYQVKPYHEGSGSLRVELPTCMYRLPNVHGRTGSPAPSADHVQEASDPSLQALESHQDDILKRLYELKAAVDGLSKMIQTPDADLDVTNIIQADEPAALSTSTVDLNAMLGQDHGALKDIVINANPASPPLSLLVLHRLLCDHYKVLSSVHTHSAVRSVPANLLQCFGEQTRQQPRHEYQLGFTLIWKDVPKTQMKFSVQTMCPIEGEGNIARFLFSLFGQKQDAVNLTLIDSWVDIAIFQLKEGSSKEKAAVFRSMNSALGKTPWLVGDELTVADVVLWSVLRQTGGCGGMAPANVQKWMQACENLAPFHTALKLLQ
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MARLVEMLMDIPPVSRVAAITAAFLSLGTTLRIMNPFLFNLSWPAIIYRGQLWRLVTSFLYFGDFSIGVIFTTVQNISYLRSLEKETFAGRPTEFLLFLFFLWASILLISFIYSMFYVTTPFFTGVMYLWGRTNPDKLISFYGIITLQACYLPIVFIVITLWQKQSIIPLLIGVGLGHVFYFLYDICPRVYGTSPIQKVAQRIERLFRR
The following text describes a protein:
Function:
Decreases host neutrophil chemotaxis induced by N-formylmethionine-leucyl-phenylalanine (fMLP); (Microbial infection) Interacts with the surface of Plasmodium berghei sporozoites. Enhances sporozoite gliding activity. Enhances host hepatocyte traversal by sporozoites.
Miscellaneous:
MISCELLANEOUS: Active immunization or antiserum against the protein reduce P.berghei liver burden in mice after exposure to the infected mosquitoes. Individuals in malaria-endemic areas have higher levels of IgG recognizing the protein.
Subcellular Localization:
Secreted.
Sequence:
MNSSWRVVVFLGLVILCHSRRARACNGGYEMIVHSIENCAGEGQIVTIDPKSTVTLMEDCKVKSKATARTVGFKTAMMDVTITKNGLPVLKETVDICANLEEASGNKEAAEIITMFGVPDHCPVAASEIRTDESQTYSLEKYKQHLLVAQGRSIIDVLVKHDKGESCFKIDMEVTSPNLIG
The following text describes a protein:
Function:
Catalyzes the conversion of monodehydroascorbate to ascorbate, oxidizing NADH in the process.
Sequence:
MAEKSFKYVIIGGGVSAGYAAREFCKQGVKPGELAIISKEAVAPYERPALSKAYLFPEGTARLPGFHVCVGSGGERLLPEWYKEKGIELILSTEIVKADLAAKTLVSAAGEIFKYHILIIATGSTVIKLTDFGVQGADAKNILYLREIDDADKLVEAIKGKKNGKAVIVGGGYIGLELSAALRINNIDVTMVYPEPWCMPRLFTAGIAAFYEGYYANKGVKIVKGTVAVGFNADSNGEVKEVKLKDGRVLEADIVVVGVGGRPLTTLFKGQVEEEKGGIKTDAFFKTSISDVYAVGDVATFPLKLYNDIRRVEHVDHARKSAEQAVKAIKSNEEGKTIDVYDYLPFFYSRSFDLSWQFYGDNVGDAVLFGDNDPASPKPKFGSYWIKDGKVVGVFLEGGTPDENKAIAKVARVQPPVENLDVLTKEGLSFACKI
The following text describes a protein:
Function:
Immune regulatory cytokine.
Subcellular Localization:
Secreted.
Sequence:
SPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN
The following text describes a protein:
Function:
Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAEIIQRIDKNNAEAPEMRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADRRGRKASMLISVCMMCMGSLVIACLPGYDTIGTWAPALLLIARLFQGLSVGGEYGTSATYMSEVALEGRKGFFASFQYVTLIGGQLLALLVVVILQQVLDDAELRAWGWRIPFALGAVLAVVALWLRRQLDETSKHETRALKEAGSLKGLWRNRKAFLMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALCVFMLVQPLFGALSDKIGRRTSMLCFGALATLFTVPILSALQNVTSPYAAFALVICALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVALSLKSVGMESSFFWYVTAMAVLAFLVSLMLHRKGKGLRL
The following text describes a protein:
Function:
Adenine glycosylase active on G-A mispairs.
Sequence:
MPRARKQTPVSAAASEPDIEDLIKCEAPDAVARESPALSTQHEAARHDFLPPELLATRTELLVWYDVHRRKLPWRGDPPPYLTTATHTSQKKKQVAAAGGKKRGMDAFLKAQVKLEVDTEQALATNTKEETVAATDDGDTVKPRKVESYETWVSEIMLQQTRVDTVVEYFLRWINKFPTVAALAEANEEDVNALWAGLGYYRRARMLHAGAKYVVENYGGELPSSVDKLLKIPGIGPYTAGAIASIAFGHREPLVDGNVIRVMARVRAVGADPKNKQLINFSWKSAKELVGECDRPGAFNQALMELGATVCTVQNPQCSDCPVKSVCLAYEEAKKLKSKPESPVSPQLPAESSSPCSICDYTRVAEWDDSQPEVTKYPLKAKKNESRNEVICVAVVSSPSTEKAVASTRRKRKASMSAESDKLDASPSDWKFLMSKRPEGGLLAGQWEFLHTKMDDGDKIPPFSKRKTFMDTRLMDLLGKSALTRSDALTPERSDLGELAHIFSHVKHHMGIEHVHFKSQPELLSAAESDELRWMTVAEMQQLGITTGVKKILQLVLHPNKSSKTKSTSKAKPRATSAKKLKTISSFFKT
The following text describes a protein:
Function:
ATP-binding RNA helicase that plays a role in maturation of the small ribosomal subunit in ribosome biogenesis. Required for the release of the U3 snoRNP from pre-ribosomal particles. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Plays a role in early testis development. Probably also plays a role in brain development.
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm. Nucleus membrane.
Sequence:
MGKLRRRYNIKGRQQAGPGPSKGPPEPPPVQLELEDKDTLKGVDASNALVLPGKKKKKTKAPPLSKKEKKPLTKKEKKVLQKILEQKEKKSQRAEMLQKLSEVQASEAEMRLFYTTSKLGTGNRMYHTKEKADEVVAPGQEKISSLSGAHRKRRRWPSAEEEEEEEEESESELEEESELDEDPAAEPAEAGVGTTVAPLPPAPAPSSQPVPAGMTVPPPPAAAPPLPRALAKPAVFIPVNRSPEMQEERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSQRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRNLPLKLLIMSATLRVEDFTQNPRLFAKPPPVIKVESRQFPVTVHFNKRTPLEDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKAFPPSRARPQEKDDDQKDSVEEMRKFKKSRARAKKARAEVLPQINLDHYSVLPAGEGDEDREAEVDEEEGALDSDLDLDLGDGGQDGGEQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNVEKVINFPFPTPPSVEALLAAEELLIALGALQPPQKAERVKQLQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEELDRPAASDEELTRLKSKRARVAQMKRTWAGQGASLKLGDLMVLLGAVGACEYASCTPQFCEANGLRYKAMMEIRRLRGQLTTAVNAVCPEAELFVDPKMQPPTESQVTYLRQIVTAGLGDHLARRVQSEEMLEDKWRNAYKTPLLDDPVFIHPSSVLFKELPEFVVYQEIVETTKMYMKGVSSVEVQWIPALLPSYCQFDKPLEEPAPTYCPERGRVLCHRASVFYRVGWPLPAIEVDFPEGIDRYKHFARFLLEGQVFRKLASYRSCLLSSPGTMLKTWARLQPRTESLLRALVAEKADCHEALLAAWKKNPKYLLAEYCEWLPQAMHPDIEKAWPPTTVH
The following text describes a protein:
Function:
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. It has lower affinity and lower activity towards 1,3-diaminopropane, cadaverine (1,5-diaminopentane), agmatine, norspermidine and spermidine (in vitro).
Subcellular Localization:
Cytoplasm.
Sequence:
MRTLKELERELQPRQHLWYFEYYTGNNVGLFMKMNRVIYSGQSDIQRIDIFENPDLGVVFALDGITMTTEKDEFMYHEMLAHVPMFLHPNPKKVLIIGGGDGGTLREVLKHDSVEKAILCEVDGLVIEAARKYLKQTSCGFDDPRAEIVIANGAEYVRKFKNEFDVIIIDSTDPTAGQGGHLFTEEFYQACYDALKEDGVFSAETEDPFYDIGWFKLAYRRISKVFPITRVYLGFMTTYPSGMWSYTFASKGIDPIKDFDPEKVRKFNKELKYYNEEVHVASFALPNFVKKELGLM
The following text describes a protein:
Function:
Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to various amine acceptors such as agmatine, cadaverine (1,5-diaminopentane), putrescine (1,4-diaminobutane) and 1,3-diaminopropane. The biosynthesis of norspermine and thermospermine from sym-norspermidine and spermidine has been also observed, but with a very low activity. The reaction involves a nucleophilic attack on the C-3 methylene of the propylamine moiety adjacent to the positively charged sulfur of decarboxy-AdoMet.
Subcellular Localization:
Cytoplasm.
Sequence:
MERAFIEWYPRGYGVAFKIKKKIYEKLSKYQKIEVYETEGFGRLLALDGTVQLVTLGERSYHEPLVHPAMLAHPKPKRVLVIGGGDGGTVREVLQHDVDEVIMVEIDEDVIMVSKDLIKIDNGLLEAMLNGKHEKAKLTIGDGFEFIKNNRGFDVIIADSTDPVGPAKVLFSEEFYRYVYDALNNPGIYVTQAGSVYLFTDELISAYKEMKKVFDRVYYYSFPVIGYASPWAFLVGVKGDIDFTKIDRERAKKLQLEYYDPLMHETLFQMPKYIRETLQRL
The following text describes a protein:
Function:
The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.
Domain:
Composed of two domains: a Mur ligase middle domain containing the canonical ATP binding site and a ribbon-type zinc finger, and a C-terminal Mur ligase domain. The GatD/MurT complex has an open, boomerang-shaped conformation in which GatD is docked onto one end of MurT. Both proteins contribute to the catalytic triad.
Sequence:
MRQWTAIHLAKLARKASRAVGKRGTDLPGQIARKVDTDVLRKLAEQVDDIVFISGTNGKTTTSNLIGHTLKANNIQIIHNNEGANMAAGITSAFIMQSTPKTKIAVIEIDEGSIPRVLKEVTPSMMVFTNFFRDQMDRFGEIDIMVNNIAETISNKGIKLLLNADDPFVSRLKIASDTIVYYGMKAHAHEFEQSTMNESRYCPNCGRLLQYDYIHYNQIGHYHCQCGFKREQAKYEISSFDVAPFLYLNINDEKYDMKIAGDFNAYNALAAYTVLRELGLNEQTIKNGFETYTSDNGRMQYFKKERKEAMINLAKNPAGMNASLSVGEQLEGEKVYVISLNDNAADGRDTSWIYDADFEKLSKQQIEAIIVTGTRAEELQLRLKLAEVEVPIIVERDIYKATAKTMDYKGFTVAIPNYTSLAPMLEQLNRSFEGGQS
The following text describes a protein:
Function:
May act as intramembrane protease.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
MDKYLNSFVDHLSEWSSRAFRNNSSSANQSASNKELEQVFEQINAIVENHNNKLTTAFDKISYRVAHKITHLVESHSLVFNYATLVLIASALVVIGSFTSISSIPFTALPPTREHSLFDPTDFDVDHDCHVIYRENDEDKKKKKKSKRFFDMMDEKHAIILPLTSGCTLLALYFVIKKLHLNWLKYVVKILNFNITLLNIPAGTFVYSYFLNSLFRNLSHLASWNPLVVLPRYRVTIADDNEDLNKIGGFVTNLNYKDGLTNSVVHKKTLDEIEKDHWMKHFYRRELVEPKDIKSKRQISNMYLNSALIVSFVLSIVSTVYFYLSPNDWLISNAVSMNMAIWSIAQLKLKNLKSGALILIALFFYDICFVFGTDVMVTVATNLDIPVKLSLPVKFNTAQNNFNFSILGLGDIALPGMFIAMCYKYDIWKWHLDHDDTEFHFLNWSYVGKYFITAMVSYVASLVSAMVSLSIFNTAQPALLYIVPSLLISTILVACWNKDFKQFWNFQYDTIEVDKSLKKAIEKKENSITYSTFILSEYYNDADKYALLGDDVNENFDDDEEFVQEEDLSDSSEEELSEEDLLDDESS
The following text describes a protein:
Function:
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Subcellular Localization:
Cytoplasm, nucleoid.
Sequence:
MGSGYAKKKKEAKLMERQFMEMEASLEQKRFSGEAGNGLVSVTINGKCDLVDVRIKPDCLDPEDPEVVADLFRAAFKAAKAALDSEMSAMQMGMPF
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MKLDKICRTCLLEKASLKPLFGACVANMLMSCASIQVIEGDGLPCQICTQCLQMVNRAYSFKQQCEKSDASLRQYINSVGLQTVSLQAEPNIMIGDMKADQLFGSSEVLQQSSIFQDIFNDATSHSLVDNFTNQNDSTVVSDLAETMQSLQTIAEQCLPETWETDTQIMSCQSNSQETNCSTFDLSNLYRCQFCEDIFKDEWTLGEHIKIHTGQNKYFCSICGKGCTTPAFLEKHIMEHSLDKNNTEEKKLCNSNYMCNICDRTFSDHKFLKKHLKEIHFTTLDDDLADVERKHVCTICNKSYKQNKLLVMHMRSHTGERPLNCEVCGRTFALPSSLYKHRNIHCTEKKYGCNICGKKFNQSSNLTAHLRTHTGEKPYICNLCGKACASSVNRDIHMRTHTGEKPYKCARCSCAFATSTQLKKHNLKHTGERPYHCWQCGKSFRQKETRDTHVRYHTGERPYACTLCPKKYIAASHLRVHLKNHNNERKYHCHICMKKFVEARILKSHILTHTGQKPYSCEYCGSQFSQSGSLNNHIKNRHR
The following text describes a protein:
Function:
Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (By similarity).
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MKAMEERTVGLISASSSRASLKTQLENGYPRICDYCEPTIEFLSSSELARHIRQDHTTQEGGSFLCRYGEHGVCQKLPLEGVCDVDFEAHIRRCHTSQSVPYSRSTSCFTEDNEEAASLRSIRLTSDRDTPTIEKKKFTLHSFTQNLSAVLADPSRSRNDLSTFFTRHWGDTFVPTQPVPTSKRLAKMADASFDSYCQAAGESYKRYQAVKRALRLSHTEGTESGNERQDAEDLPTVFIDPRFTLGDSSTFSAVFTVPANENLDALKQTLSGKNVIPATPLEVAINKKPGEFRDYEALQNRLEMMHDVVDGRLAGKLVAKTDDFWQVVRSYSGLQEQLANALQCVMVVRKNLKHVDELVCDQTKKIIEVHQKYEQKKHLLAKLNDIACLREAQSTVQMMLSQGDYPKAIECIETSLDVLSKELNGVTCFRHLSSQLRELYSVIGRMMNEDFTSLIQKEFGVKPEAGTLIQAEGELSAVLLGLMRMRKYTFISVLREEIIEGVKSVMRHVIKSQILNSGVDLSDFDPSLTQLGEPVRRMKHADFLKTVRAVMDEEYFFCKRLEALQDILLETAQRAHPSNRHGSEDIIIERLEEAKLNESDSDDETGSFSKSTSSGGFVSGSAVNSNATATTLLSIEVRSEAFLKRVLPLIAEFGHQCAQQRISRLLIARAKNASVTEATTPTQLSECIAIVKEYQSQCEEEGWYSTQNQKAGGLGRAINKLSMDYIEKFHAARKMRIGNMLDTELWKATDVSIIDQNMVDQAIETGMLRSSKRIDDGPTKKPFKRTGSSATIDSGTSVSNQTGIIVDEESFVVVGSSITMIQILADYCEAISKMPTFAQDWNSRVIELLKTFNSRCCQLILGAGALQLVGLKTISVRNLGTIFVNLTLAGRSLELVCRFIPMVHDEMDRVLPDDRKSLLRYFKGVESEYRDHVNEIAIKLISVIAHYTTNCLGMWDVKGNIPSPEFQQICRHMLKFHNGLTGIMPRDQIESLFRQVHENFKANLREHVTGMGIRPHDTLKYGYVTQDYMYYQQNVKNMESCRNLELESLNDIMFD
The following text describes a protein:
Function:
In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts an anti-sigma factor and thus releases a sigma factor from inhibition.
Sequence:
MNNLKLDIVEQDDKAIVRVQGDIDAYNSSELKEQLRNFISTTSKKKIVLDLSSVSYMDSAGLGTLVVILKDAKINGKEFILSSLKESISRILKLTHLDKIFKITDTVEEA
The following text describes a protein:
Function:
Nonessential protein required for the fusion of ER-derived transport vesicles with the Golgi complex. Can be replaced by SFT2.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MWLTEAQKFGVAFTFGGFLFFLFGIFTFFDRALLALGNILFLIGVFLIIGSQKTYIFFTRPNKRRGSLFFLVGAFLILLKWTFLGFIIESLGIIGLFGDFFGVIVQFLRSMPIIGPILSHPAIAPIVDKLAGVRVLPV
The following text describes a protein:
Function:
Required for autophagy.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGQPPAMEVPEDAAIQKVVWEGNFPLRIQLEAKEVTTLTPPPPLFLMAPRLGYLPLLASKIEPHFRAALPPGTDAIWFEYRGLPLKWHIPTGVLYDLLAEEKTLPWQLTVHFRTYPSELIPIEGEETVKWSYMNALKEAVYIMHGSTKPVMSLSQKDQEELWRSLAEGDFNRHTSSAASLGVSTSSRPRSVPLRLYLRQAGTSGAHVKKWEEIAVTTRCADVMDSGSPATLGGALHKAVPHLFDEGASNNLPALATELGRRVSGLEIEPSTSRRNSITEELTDSPRDTSRRGSSAESPGGVPSAGTSGMVRETSEEGSGGVGSESTTPRGSEAGESDEASLAKKEVGAEGGGEVHSDVVDRSFPNGLVVRIQGTEPRWDVPLNWLSRNLSHPDHFLHISVWRREAGQE
The following text describes a protein:
Function:
Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance.
Subcellular Localization:
Mitochondrion.
Sequence:
MLKIFIVRGFSTVIKRPKVKLSKADVIKRLNYENKALFGAVIKPTAKRKTKTKSTEQVTLPKTTAHPVVESEYTSEIFWQSRNFSRVKTPNGDGGENESYPTGLVIPFTDKELQAITKFPLVPSDRGFVESQWKLHEQHESDQYKSPSVNRILSATMPEASRQALIRWKTSKIAELGEEGFQLLQKEIFARGSTLHATLETWLSGCDPSEEAIEKTGILWRSVSGALKDVERPAKLIEQKLYHPYLHYNGVVDCITSIKGHYHVIEWKTSDNPKTSVGATYDAPVQLCAYLGALQANGEHCDSRIQKGAIFVAYTSGKPANVHILEPSEMRRYWLQWLHRVQEYWTRYRDGTLPEPI
The following text describes a protein:
Function:
Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity (By similarity). Acts as a non-canonical executioner caspase during apoptosis: localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation. Lamin-A/LMNA cleavage is required for chromatin condensation and nuclear disassembly during apoptotic execution (By similarity). Acts as a regulator of liver damage by promoting hepatocyte apoptosis: in absence of phosphorylation by AMP-activated protein kinase (AMPK), catalyzes cleavage of BID, leading to cytochrome c release, thereby participating in nonalcoholic steatohepatitis. Cleaves PARK7/DJ-1 in cells undergoing apoptosis (By similarity). Involved in intrinsic apoptosis by mediating cleavage of RIPK1. Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP (By similarity). Cleaves phospholipid scramblase proteins XKR4 and XKR9. In addition to apoptosis, involved in different forms of programmed cell death. Plays an essential role in defense against viruses by acting as a central mediator of the ZBP1-mediated pyroptosis, apoptosis, and necroptosis (PANoptosis), independently of its cysteine protease activity. PANoptosis is a unique inflammatory programmed cell death, which provides a molecular scaffold that allows the interactions and activation of machinery required for inflammasome/pyroptosis, apoptosis and necroptosis. Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death. Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis. Regulates B-cell programs both during early development and after antigen stimulation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The N-terminal disordered prodomain is required to prevent self-activation; The Tri-arginine exosite is required to recruit substrates for hydrolysis; Undergoes helix-strand structural transitions upon substrate-binding: the 130's region interconverts between an inactive helical state and the canonically active strand state. Other caspases rest constitutively in the strand conformation before and after substrate-binding.
Sequence:
MTETDGFYRSREVLDPAEQYKMDHKRRGTALIFNHERFFWHLALPERRGTNADRDNPTRRFSELGFEVKCFNDLRAEELLLKIHEVSTSSHVDADCFLCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRGSQHDVPLVPLDVVDHQTDKLDDNVTQVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLSEMLARHGSSLEFTELLTLVNRKVSQRRVDFCKDPGAIGKKQVPCFASMLTKKLHFCPKPSK
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Has very low activity with CTP, GTP, ITP and UTP and no activity with GMP, UMP or IMP in vitro.
Subcellular Localization:
Parasitophorous vacuole membrane; Lipid-anchor. Note=Localizes to the vacuolar side of the parasitophorous vacuole.
Sequence:
MGSCYSRKNKVSTISLDEEEKKKEKKKKKKIYILNGASGSGKDTQCRLLEKKYNYKIICISKLLKEYKEEYNKENVLNEEENYFDEIEKCMIDGSLVNDQIVIEIFHKQLNKYINDDKYNGIIINGFPRNYEQALLIIQNNISITKFINIQVGKDTLWTRINNRIIDPITNISYNENIIQIIKKKREGQELSDKEQKQLIIDNHLYNNLSNDILERLTKRKDDEEQVFNKRFQLYIESEQKINSLFKNICKNVDGEKSINDIFDQICSIIDDNPN
The following text describes a protein:
Function:
May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway.
Subcellular Localization:
Nucleus.
Sequence:
MAASPADASRRRREKRRQLDARRSKCRIRLGGHMEQWCLLKEQLGFSLHSQLAKFLLDRYTSSGCVLCAGPEPVAPKGLQYLVLLSHAHSRECSLVPGLRGPGGQDGGLVWECSAGHTFSWGPSSGPKSPEEPNLTPLPSTDERSWCPEAKSGQEPAGLESNCDERAQEARMPRGAGPPPETFPSLGEDGEEEEEDEEEMLSDASPWTYSSSPDDEPDVPKPPPSPVTHALKDGEIAPAPAAVPAPLASPSSSASSLGSGAPGPVEVRIQPELRGTPQADQQTEPLASPGSQAQSALASAWDEDTAQIGPKRIRKAAKRELLPCDFPGCGRIFSNRQYLNHHKKYQHIHQKSFSCPEPACGKSFNFKKHLKEHVKLHSDTRDYICEFCARSFRTSSNLVIHRRIHTGEKPLQCEICGFTCRQKASLNWHRRKHAETVAALRFPCEFCGKRFEKPDSVAAHRSKSHPALLLAPQELSGPVESCSSILASASLGASEGSRSTLAPQAPILLP
The following text describes a protein:
Function:
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
Sequence:
MATPCIQNAFRRKTLPVRIGDLFVGSEHSIKIQSMTTTATTDVDGTVRQICALQEWGCDIVRVTVQGLREVHACEHIKDRLIQQNISIPLVADIHFFPQAAIHVVDCVDKVRINPGNYVDKRNMFTGKIYSDEQYAHSLEHLMNKFSPLVEKCKRLGKAMRIGVNHGSLSERVTQRYGNTIEGMVYSALEYAEVCVAMDYHDVIFSMKSSNPKVMVAAYRSLAYELDQREWSYPLHLGVTEAGSGTAGIVKSAVGIGTLLSEGLGDTIRCSLTGSPINEIPICIDLLKQTTELSERWGEADNPFAIHSSKQLGTRNTLNTPPWGNVYGLLINLTDVQLLTAEPIELLQCLGIDTTTGKIDPTTPEGVVVPKAMRSSPIVSEIEKHLLVFNKEDVPILNPMNEEEWLSEETLSAPFVYFEVTDIHTARRFFSLRQHSTQPVCLSFSLDPHLSKNEAIIDLSARLGALLLDGLGSCVLLDFVDIKLSRTLGFLILQSANIRSVTVEYVSCPGCGRTLFDLLAVSQRIRERTQHLPGGLKIAVMGCIVNGPGEMADADFGYVGSKPGMIDLYVKHKCVKSCIPIENAEEELVQLLKEHGVWKEPE
The following text describes a protein:
Function:
Can act as both a transcriptional repressor and corepressor. Represses the expression of genes involved in neural development and preferentially binds palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression. Acts as a corepressor for suppressor of hairless (Su(H)) and inhibits Notch signaling during peripheral nervous system development.
Subcellular Localization:
Nucleus.
Domain:
The BEN domain mediates DNA-binding.
Sequence:
MENQYQRIVSATAREDSQARRSKPLFLNAWSQTSSVDFEVLRSISAPDPQVEVENRALRDKVRYLEAKLQQHKDLLSQIHATSARMQQASSLLAESRPPTPPAVQSHHILTPPSSEICAPAQNPQILDYKIISAPDDADAIEIRLAAESLNSLSTSADSDRLEICLGDENHQQSNHHNSQQQYRISNGIKRDGSSESADTPLQFIKRRKLQEIQLQEEIPRQNIKLPAKPQVKARNGSFTDLNKGQQQNMDNVMVSIGPNNTCVPASVFENINWSVCSLATRKLLVTIFDRETLATHSMTGKPSPAFKDQDKPLKRMLDPGKIQDIIFAVTHKCNASEKEVRNAITTKCADENKMMKIQNVKRRSSGIKHEKENII
The following text describes a protein:
Function:
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
Subcellular Localization:
Cytoplasm.
Domain:
The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.
Sequence:
MEKINAVITGVGGYVPDYILTNEEISKMVDTNDEWIMTRIGVKERHILNEEGLGSSYMARKAAKQLMKKTGANPDDIDLVIVATTTPDYHFPSTASILCDKLGLKNAFAFDLQAACCGFLYLMETAANFIRSGRYKKIIIVGADKMSSMVNYTDRATCPIFGDGAAAFMMEPTTEDLGVMDSILRTDGKGLPFLHMKAGGSVCPPSYFTVDNKMHYLHQEGRTVFKYAVSSMSDVSAAIAEKNGLTKDTINWVVPHQANVRIIEAVAHRMELPMDKVLVNIEHYGNTSAATLPLCIWDFEDKLKKGDNIIFTAFGAGFTWGAVYVKWGYDGKKES