lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: It is unsure whether this isoform is produced by alternative splicing or alternative initiation.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein.
Domain:
The DBB domain is required for dimerization.
Sequence:
MTASGTHGGYDVLILYASDAAEWCQYLQNLFLSTRHIRKHHIQSYQLEGESAISDQELDLFNRSRSIIILLSAELVQNFYCPPVLQSLQEALWPPHKVVKLFCGVTDCDDYLTFFKDWYQWQELTYDDEPDAYLEAVKKAISEDSGCDSVTDTETEDEKTSVYSCQLAMNEEHESSKSTGEHLVVQPDHIRCGVQTTVYIIMKCRLDDKVKTEVEFSPENSSSVRVLAELENEYTISVEAPNLTSGTVPLQIYSGDLMVGETSVTYHTDMEEISSLLANAANPVQFMCQAFKIVPYSIEALDKLLTESLKKNIPASGLHLFGINQLEEDDMTTNQRDEELPTLLHFSARYGLKNLTALLLTCPGALQAYSVANKYGHYPNTIAEKHGFKDLRQFIDEYVETADMLKSHIKEELMQGEEDESVYESMAHLSTDLLMKCSLNPGSDEELYESMAGFVPGAPEDLYVEMLQSKPDTPISGDEISLTVKDSMLRKFLEGGSTDAPDSGEGVSQQYGEDLYYSVEKDTFPQEMASRPPVPVPRPESSSPQPDNELYISKVFAQKAQRPENLYVPRGKVRKETIVRPVRDLSQSSIYDPFAGMKTPGQRQLITLQEQVKMGILNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRDSITRRQMEKQKSGKSADLEITVPIRRSHNTLGKPECGIYEYAPRKNIFPPKKELKRGDWKTESTSSTTSSASNRSSTRSILSVSSGMEGDSEDNEVSEASRSRSPIPSQAERLPLPLPERPPRVPPRGASRPVNCEGFYPPPVPPRGR
The following text describes a protein:
Function:
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons.
Subcellular Localization:
Synapse.
Sequence:
MSMNTFREGFTSGMSYLKRRFSSNDLQGDLMNERTDSTGFSFNLPKRRGPSPSAPSSPSRSTSIQGLTRGLFGSSSSSTQPPKPAYNKDRCKTLLVIDTPNVEWTKYFRGRKLLGEWDLRVEQAEFSEINLAAYSETGTVVDIQVMRNGTKVVRSFKPDFVLVRQHVKDATENWKNIIIGLHYGQIPSLNTFESIYNFLDKPWVVSAAMKIFVWSFFLSRARFPLIEQTYFPNHKEMLVSPHFPVVVKIGHAHAGLGTVKIDNHYDFQDIISLVALSGCYCVTEPFIDSKYDIHIQKIGDTYKSFTRTSISGNWKVNTGSSMLEQIPTTERYKRWADECSELFGGLDMVAIEAIMGKDGNEYILEINDCTMPLLGETQEDDRKLIASLIINKMEANCREEMSKSASISQMSVVNSRPMAGPPGPSPASTAMPMEFDATLAAHQSPMMLNSNQQQQQFQQQQQQHFQLQQQQQFQQQQFQPQQQMSESEVAKDLEDSEDTMKNLRKTFAGIFGNM
The following text describes a protein:
Function:
Transcription factor involved in the regulation of tapetum programmed cell death (PCD) and degradation during male reproductive development. Promotes tapetal PCD. Positively regulates the expression of two tapetum-specific genes, the cysteine protease CP1 and the lipid-transfer protein C6. Acts upstream from and interacts with EAT1/DTD in the regulation of tapetal PCD. Regulates the expression of genes related to aliphatic metabolism during pollen development. May play regulatory role in the lipidic metabolism involved in the formation of pollen wall.
Subcellular Localization:
Nucleus.
Sequence:
MGRGDHLLMKNSNAAAAAAAVNGGGTSLDAALRPLVGSDGWDYCIYWRLSPDQRFLEMTGFCCSSELEAQVSALLDLPSSIPLDSSSIGMHAQALLSNQPIWQSSSEEEEADGGGGAKTRLLVPVAGGLVELFASRYMAEEQQMAELVMAQCGGGGAGDDGGGQAWPPPETPSFQWDGGADAQRLMYGGSSLNLFDAAAADDDPFLGGGGGDAVGDEAAAAGAWPYAGMAVSEPSVAVAQEQMQHAAGGGVAESGSEGRKLHGGDPEDDGDGEGRSGGAKRQQCKNLEAERKRRKKLNGHLYKLRSLVPNITKMDRASILGDAIDYIVGLQKQVKELQDELEDNHVHHKPPDVLIDHPPPASLVGLDNDDASPPNSHQQQPPLAVSGSSSRRSNKDPAMTDDKVGGGGGGGHRMEPQLEVRQVQGNELFVQVLWEHKPGGFVRLMDAMNALGLEVINVNVTTYKTLVLNVFRVMVRDSEVAVQADRVRDSLLEVTRETYPGVWPSPQEEDDAKFDGGDGGQAAAAAAAAGGEHYHDEVGGGYHQHLHYLAFD
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Sequence:
MAMLLNRSMGSRTLVSPLRTLTTTRSSSTNLLSQLQHQPVYQAYCPKSYHSSRTTSQTIFQTRAQSTTTSSKKMPLKVGDTIPSGTFSYIPYTPELSSPTVCGNAIDLKTDQWKGKKIVLFGVPGAFTKTCSANHLPAYVKKAGELKSKGISGIYCIASNDAFVMSGWGRLLGSNEHVEMISDSTLKWLEEAGLTVDLSAHGLGKRGTRFALVIDDLKVTYVGIEESPGSVSVSGVDAVLPKL
The following text describes a protein:
Function:
Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MDSAASVAGAPPAVPPAVLCAAEEALAATESVGDHLAEMLAAAAEDPDAIAELPPLQRARAFLAVAHAATSLFSVRLRCSGINPDEHPIKKEFERLSLWQEKLNRLNEWDKAPLRPSTTVNTQAAARFIGRSLSHLTDDQKRGMQAISKGEGAGWSGRKRKSQPLPERKSVRAAAEEFLAKASQELIGYNGSGVKGPVRTVFDEDED
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells; Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRITMASRVASTSVFHQLLFLPLLAGHCAAAAAAVATTGTAPVVASVPLDVGVILDLATGLGKKSLLGMEMAVHDFYAAHPGYTTRVKLHVRDSNRSVVAAASAALDLINNKKVGIVIGPQNTLQAEFLTYLANTTKVPVITSSATGDTVTQYHVPYFLRACVKGSFQAASIAAFVKSYGWKNVVLVYEDNNYGAGILPSITDALEAVDVHVINRSAIPTSCPGDRIDAELYKLMTMQTRVFIVHMLPADAARLFARASAIGMLTEGYVWMVTDDIGIALDVLPQHTTETMLGVVGFRPYVAKSTRITGFMDRFVTRYRAKYHQDPDVRVAKPTMFQYWAYDVVWAIASATEKSKRPRSLNLGSTTGYMGKLVDDLQPSPAGPELLASIIGGEFYGLAGRFRFVDRHLPVPQYEIVNVIEEKIRRIGFWSPGYGLSAFLNSSTRPGQARRRAKAGQVLRAVIWPGDSITVPRGWDFPANGKILQIAVPVRRDFKVFVKVENPNSSMQSVTGYCIDVFEAAVKKLPYALPFKYMPYDCANSYDKLVSQVYFKTYDGAVGDVTIIANRTRYVDFTVPYTESGVSMLVLARKDEDEPTMWIFLKPLTTDLWIAMVVFIVFTGLVVCTIEKPVNDQVQGSKWKQLNTYFYFAFSTGTSTHDQKFKSLQSKVIMVSWCFVLLVIVQSYTASLSSMLTAKRLQPLVTDPMQLLHKGDYVGYQNGSFVHSMLRRLHFEDRQMMSFSTREEYADALRKGSKEGGVSAIFDETPYINSFLLLYGKDFQKVGPIDRTVGFGFAFPKGSPLVEDLSKAMLNLIEGSEGSDIERKWFGDRILSLDYGSPDTSFSRLSSRSFKGLFIINGCILGLMFLINCSRYAYAKFTAKRKAAAASDGEAQPSTNGNDIPAV
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTDDPAATPRPETSVNARPAFSGQAPIKAEYLINTTPIVESASASELNNIHPDDAAEGRTDSRDSRDGRDRPDNKRRKPNKQDKKDKKGQNKGRHFPVIREASVRICRAWETTGICDRADKGDCRYAHSWEGYFEVKPNDISYRPDWSLVGEAPFVVEGERVVGGEDVVGKTLDLDTVCPVLKDLGYCPFGWRCRFLGAHVKRVAAAVDGEKEKEAGPEKRMGEWQVENWVQSEVENGWKQKETNWPEHEVLNALRRSTASFPFSEAYLKKVDPDKPFTLQNKKPTKQQPHKRKNNVLDEEEAANGPTGIPSAGDDEENAMNATENERNEEKGKVYGEPEAIDVPLRPEEKRRLNWEGGRYLAPLTTVGNLPFRRLCVDYGATITVSEMALAQPLVYGAKEEWALVRRHESEKMFGVQVAGGFPNRMVPAAEVIANTIGKGGGVDFVDVNMGCPIDLVFNQGAGSALMDSPGRLGKLLVGMNRALGDIPLTVKFRTGVAHGKPNAHKLIPRFVTEWGAGALTIHGRSRQQRYSKPADWEYIKTCVTALRESVADANLPPVPIFGNGDCFSAASYYEEMDRSGVDGVMVARGALIKPWIFTEIKERREWDISAVERLEGIKKFAEFGLSHWGSDTQGVNTTRRFLCEALSFQHRYIPIGLLERLPAKLNERPPAYRGRNELETLLASPFAGDWVKISEMFLGKVDEGFSFVPKHKSNAYGGEEAQG
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.
Sequence:
MECLLTSGVGSACLRPGAGVGVSAQGQWRRAFFGSDREVKLRKCWSERRARRFATSASVVEYDVVIVGAGVIGVATAHHILTTTPLSVALVDAREPCAGATGAGQGYIWMTHRKPGTPGWHLAKRSKALWETFAMEVEDSGLNPTEALGWRKTGSLLVASTDEQAKYLQNWAQVLSEAGAATDFLTHLEAVNMEPALATGCLTAAALCHDDLQIDARLTIDTLLQRVRDFESRGRYKELFQSPVQHFIRSSREGRLIGVEIPEGKVFGKSAVVIATGAWSSLLMKTATTEWGMSLVPPMKPRKGHLLVIEGTHDIQLKSGIMECEYLSYNSQSSKSTEATTEPGPSIVMTATLDPNGNLLLGSYREFAGFNIDVQDEVIEKMVERAARFLPGVSNMEGRVRTGLRPYINDGRPMIGPVDDVPGLIFATGHEGSGLCLSLATAEMVTNIIQDVKGPVESAPFLPNGRLSSSTM
The following text describes a protein:
Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MKPPQRRRKVPARYTGEATGPTAWSPREMRHLLRLLQARRGQPEPDAKELAKELRGRSEAEICRFIQQLKGRVVREAIRKVQPGGRDGPRHRETQLPAPIEVWMDLAEKLTGPLEEALTAAFSQVLTIAAAEPLSLLHSKPGKPTKACGRALVFLSTQDAQKDPAPEGSGPEPMTAADPTPEASVPEPKASGTNPETSGLVPEVSVPDPDAPTESLAGSSTERDFAVDFEKIYKYLSSSSRGGHGPELSAVESAVVLNLLMSLAEELPHLPCTALVDHLTKTYAQLTAPQASLDREKRPRPGTEDGGTDSTGPEETGQGSPQASEPTEPRLTWKAAGVCPLNPFLVPLDLLSQALAPAR
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Sequence:
MALNVGDKAPDFTAKDTHGNTVSLASLAGKKFVLYFYPKDDTPGCTKEACSFRDNWSTYQAQGLGVYGVSMDDEASHQAFTSKYALPFPLLADTDGTLAKAYDADAGNYAKRITYVIDEAGKIAQVFTSVNSASHASDVLAAVGV
The following text describes a protein:
Function:
May be involved in cellular signaling or cytoskeletal functions. May play a role in morphogenetic control.
Miscellaneous:
MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
Sequence:
MKGVKKEGWISYKVDGLFSFLWQKRYLVLNDSYLAFYKSDKCNEEPVLSVPLTSITNVSRIQLKQNCFEILRATDQKENISPINSYFYESNSKRSIFISTRTERDLHGWLDAIFAKCPLLSGVSSPTNFTHKVHVGFDPKVGNFVGVPDSWAKLLQTSEITYDDWNRNSKAVIKALQFYEDYNGLDTMQFNDHLNTSLDLKPLKSPTRYIINKRTNSIKRSVSRTLRKGKTDSILPVYQSELKPFPRPSDDDYKFTNIEDNKVREEGRVHVSKESTADSQTKQLGKKEQKVIQSHLRRHDNNSTFRPHRLAPSAPATKNHDSKTKWHKEDLLELKNNDDSNEIIMKMKTVAIDVNPRPYFQLVEKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSEQPKKQLIMNELLVMNDSRQENIVNFLEAYIIDDEELWVIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRSKRATMVGTPYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRASVRKLLTFEFLSMACSPEQLKVSLKWH
The following text describes a protein:
Function:
Binds to and hydrolyzes insoluble and soluble xylan substrates.
Domain:
The GH10 domain binds to xylan.
Sequence:
MKRFNYGFFHLVLFLISLLLLGSGICMDPFSYDQSLKSECLMEPPQTTANTGGEGVKELKINENGGIRNVVEGVDLREGNIYITSAWVKLRNESQRKVGMTFSEKNGRNVFGGEVMAKRGCWSLLKGGITADFSGPIDIFFESDGLAGLEISVQNVRMQRFHKTQWRLQQDQVIEKIRKNKVRFQMSFKNKSALEGSVISIEQIKPSFLLGCAMNYRILESDSYREWFVSRFRLTSFTNEMKWYATEAVRGQENYKIADSMMQLAEENAILVKGHTVLWDDKYWQPNWVKTITDPEDLKNVTLNRMNSVMKRYKGRLIGWDVMNENVHFNYFENMLGGNASAIVYSLASKLDPDIPLFLNEFNTVEYDKDRVVSPVNVVKKMQEIVSFPGNNNIKGGIGAQGHFAPVQPNLAYMRYALDTLGSLSFPVWLTEVDMFKCPDQVKYMEDILREAYSHPAVKAIILYGGPEVSGFDKLTLADKDFKNTQAGDLIDKLLQEWKQEPVEIPIQHHEHNDEEGGRIIGFSPEISLLHGHYRVTVTNPSMKNLSTRFSVEVTKESGHLQEVQLVIDA
The following text describes a protein:
Function:
Involved in copper homeostasis.
Sequence:
MIREMSNHDIKLEVCVDSIRSAFAAEEGGASRIELCSALGEGGLTPSIGTLKTIKETLTMPIYCMLRPRRGTDFVYSDEEMCALLTDMDLLRENGADGFVFGSLNPDRSINVDQCRHVLLASGGLPVTFHRAFDLTDQKSMDENVDMLRELGFRRLLSSGFRPTAADGVDCLAQLIAKHQRDFIVMPGAGIKVSNLEEILTVSRCLEFHASALDTAGEDYVAPTTTRMECDVTMGKQDVDPYYGTNSIVVRKMVTIAKAMSSR
The following text describes a protein:
Function:
Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the KinB activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLFACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPSAMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNILNFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAASVAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQLYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKNSIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGLTVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH
The following text describes a protein:
Function:
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Subcellular Localization:
Cytoplasm.
Sequence:
MLLKLKCTVNNYAWGPKGNSSMAGSLALDGGHIPNLDKDKPYAEFWVGTHANGPAHVIEKDIALKQLLATSPELQGKHEKGNLSFLFKVLSVLGPLSIQIHPTKEQGKLLHATDPKNYPDDNHKPEIAIALTEFELLSGFRQHSQISEYLKLYSEIQELLTEEEKSQIDSLGSYGESSAQVLKKIFSRIWRTPKEKLQIVVDKLARRIQGHENKTALDEIIVYLFTLYPGDVGVFAPIFLNYFKLQPGEATFLEPNMPHAYLKGDCVECMADSDNTIRAGLTPKYIDVESLVEMLNYDETLLPKYIPNELDDGSLLFTPRGIDEFWVQEVKGPAGSIYQLPYSESCSVLTVLYGTATVTLGDASQVLNRGEVVFIGATHDAERPKINISDDFLAFRAFTPSPRALESLSNKRLIID
The following text describes a protein:
Function:
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and MAP3K7/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9; [Isoform 1]: Blocks staurosporine-induced apoptosis. Promotes natural killer (NK) cell-mediated killing; [Isoform 2]: Blocks etoposide-induced apoptosis. Protects against natural killer (NK) cell-mediated killing.
Subcellular Localization:
Nucleus. Cytoplasm. Golgi apparatus. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.
Domain:
The RING domain is essential for autoubiquitination.
Sequence:
MGPKDSAKCLHRGPQPSHWAAGDGPTQERCGPRSLGSPVLGLDTCRAWDHVDGQILGQLRPLTEEEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAKWFPSCQFLLRSKGRDFVHSVQETHSQLLGSWDPWEEPEDAAPVAPSVPASGYPELPTPRREVQSESAQEPGGVSPAEAQRAWWVLEPPGARDVEAQLRRLQEERTCKVCLDRAVSIVFVPCGHLVCAECAPGLQLCPICRAPVRSRVRTFLS
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDGNQKPDGNSGEQVTVTDKRRIDPETGEVRHVPPGDMPGGTAAADAAHTEDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERARKHGDLESGPLKSVADKLDSALTGLGLVAFGAEGEDFDPVLHEAVQHEGDGGQGSKPVIGTVMRQGYQLGEQVLRHALVGVVDTVVVDAAELESVDDGTAVADTAENDQADQGNSADTSGEQAESEPSGS
The following text describes a protein:
Function:
Involved in trafficking and recycling of synaptic vesicles.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Early endosome. Golgi apparatus, trans-Golgi network. Late endosome. Membrane; Multi-pass membrane protein. Recycling endosome.
Sequence:
MNMKPHQIGQIDEFELQNTSKDDGHSTIQSFKEQELFHLNAIPKKIVAITIMLTILGITFLIIGVLLLFKQPSNYDQYLPLLFIGILMTIPGIYYSYKIIQFAYSRSRQEQEQIIQELPIDY
The following text describes a protein:
Function:
ATP-dependent helicase involved mating type switching and in silencing interference through its interaction with the silencing regulator SIR4. Cooperates with UBC4 and UBC5 to mediate ubiquitination of SUMO conjugates.
Subcellular Localization:
Nucleus.
Sequence:
MAAVPTIDLTLADSDNEDIFHSFSSSTSVDKIDIRKENGKLRMAGLEVAQSNDDAARQAFHVFKTNISNNETFDTILSKSKTITDSTFNNEKSSNEVKQQQVLKEETMGSSNDEKKTQESSPSAEMIKLFYENDDVPLSDSFKQKEEGKRINQDEQVKENICGISSSYVSKDYDGVEDDFEPNTCQDSNLDFQEEKLNLNNKPSQQQFSDPETKDNSLKSENKDQIKGVTTTSYRDLPIESSAFQDSETQNNSKNTIPNIVNEKRTPALPSNLSSVESSLKNETAKVEGKTTVRLPGLQNNVALLEQEQSELFKHFSEQPVDISDFGRKIKRKHSGDFADNKILKRPILPSKNMDHTTHNSHDSEQKNSSIIILSDEDESGAGINDIESPLKVSEPNTADALRSSVPEVISLLDLPNIDLNNSVIKEASGSNSIPTSETDAQSSSSSVLQGTIMTEQATQSSQHECNSSLDTLKKNHQKLLKDLNSRESELRNALSCCKTNSEILRRKLSRREKEVSDAEKHWQLLLTSMARGGRTISSTQQILVDEAENQLNKLKEKRQLTKSKLDSINLKMYNYNEQWKSFVHSKNINLQKSLAALERSARDSKASATVNKRNECLAEKEKLDQMLKEGTLSFSTYKQLTGEIQQKLNDLKLGDQRTTDINSVLPIVRQPLAKRDLFIKSIDTAKDLLAKNTSRTEMTKRILYRHLDNLVSYKNFFEDGRSLIDINRRHVAHESAQILFTNGVKMPIVFETLQDYGIKFSNPAIVNPDRRAQYFKSIEVARDLISKSTRSEDAKRKITRFLNIIEEFRKDIDTGFPPTPLKREGVGKAVVGLRQQGLKMDRLYENLRRYKIPITSEELLQQSYLFPVNADQRPPSNWNIVENTEDTSSTANDLSMQDEFHISNMHAAEDQEQIRALLENVKQSESIIDGEALTPEDMTVNLLKHQRLGLHWLLQVENSAKKGGLLADDMGLGKTIQAIALMLANRSEESKCKTNLIVAPVSVLRVWKGELETKVKKRAKFTTFIFGGSGNGKVKHWRDLARYDAVLVSYQTLANEFKKHWPKKLDGEQNQLPAVPHIQALNRLKTSNEYYSPFFCNDSTFYRILLDEGQNIKNKNTRASKACCTINGMYRWVLSGTPIQNSMDELYSLIRFLRIPPYHKEQRFKLDIGRFFQRNKQYQYDNEDRKNALRKVRVLLNAIMLRRSKADKIDGKPLLELPPKIVEVDESRLKGEELKFYTALESKNQALAKKLLNNSTRGSYSSVLTLLLRLRQACCHSELVVMGEKKAEGTKVANGKSFEDDWLRLYYKITHMSGEAQAQVITSMNSMTCFWCMEQLEPEAMSVLTGCGHLICDTCIEPFIEESSMLPQAKKTKGGAFAIPCKDCQRLTNEKDIVSHKLYDQVINQGFTEEDLHAEYLSEMEKQKIQQKNVYVPNFESLEPSTKIEQCIQVIQRVFDESATEKIIIFSQFTTFFEILEHFLKNKLNFPYLKYIGSMNAQRRSDVINEFYRDPEKRILLISMKAGNSGLTLTCANHVVIVDPFWNPYVEEQAQDRCYRISQTKKVQVHKLFIKDSVEDRISELQKRKKEMVDSAMDPGKIKEVNSLGRRELGFLFGLNAL
The following text describes a protein:
Function:
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1 (By similarity). Essential for embryonic development (By similarity).
Subcellular Localization:
Cytoplasm, P-body. Nucleus. Note=Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (By similarity).
Sequence:
MESLSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVLEEETRRSQQAARDKQSPNQANGCSDHRPIDILEMLSRAKDEYERNQMGDSNISSPGLQPSTQISNLGSTETLEETPSGLQDKSALSGHKHLTVEELFGTSLPKEQPTVVGLESEEVEKLPGDASQKEPSSFLPFSFEPSGGGPQSENMGIRPAAHHSVQPEVTTPVLITPASITQSSEKQAPSYAIPLHPVLSPTLPAEASTAQAPPSLPRSTTMMQAVKTTPRQRSPLSSQPVPELSQASLAASQSPFRAPLNVTNTASTSLPSVDLLQKLRLTQQHDQIQTQSLGKGAVAPSFSPAAGQLATPESFIEPPPKTAAARASASLSNMVLAPLQSMQQNQDPEVFAQPKVLSSAIPVAGPALVTATTSAVSSVLLSPSVFQQTVTRSSDLERKASSPSPLTVGTSENQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHEVYLQVLTKNKDNHNL
The following text describes a protein:
Function:
Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
Sequence:
MLSLENQRILVTGGAGFLGKQVVAQLIAAGGDRPKITIPRSKDCDLRQASACERAVENQDIVIHLAAHVGGIGLNREKPAELFYDNLMMGVQLIHAAHQAGVKKFVCVGTICAYPKFTPVPFKEEDLWNGYPEETNAPYGVAKKALLVQLESYRLQYGFNGIYLLPVNLYGPEDNFDPRSSHVIPALIHKVYEAQKAGQKQLPVWGDGSPTREFLYSTDAARGIVMGTQAYDKADPVNLGTNFEISIKDLTELICELMEFEGDIIWETDQPNGQPRRCLDTTKAKAEFGFEAQVSLREGLKNTIDWYRQQRS
The following text describes a protein:
Function:
Involved in spore outer coat assembly. May be part of a cross-linked insoluble skeleton that surrounds the spore, serves as a matrix for the assembly of additional outer coat material, and confers structural stability to the final structure.
Sequence:
MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDLYETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQVECENQILTVAVNKETEDGSSFSLQFPLS
The following text describes a protein:
Function:
Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (By similarity). Phosphorylates SPC105 on MELT motifs; phosphorylation is required for recruitment of the BUB1-BUB3 complex to kinetochores. Phosphorylates CNN1, which contributes to the enrichment of CNN1 on anaphase kinetochores. Implicated in spindle pole body (SPD) duplication. Phosphorylates the SPC29 and SPC110 spindle pole body components.
Sequence:
MSTNSFHDYVDLKSRTNTRQFSDDEEFTTPPKLSNFGSALLSHTEKTSASEILSSHNNDKIANRLEEMDRSSSRSHPPPSMGNLTSGHTSTSSHSTLFGRYLRNNHQTSMTTMNTSDIEINVGNSLDKSFERIRNLRQNMKEDITAKYAERRSKRFLISNRTTKLGPAKRAMTLTNIFDEDVPNSPNQPINARETVELPLEDSHQTNFKETKRNTDYDSIDFGDLNPIQYIKKHNLPTSDLPLISQIYFDKQREENRQAALRKHSSRELLYKSRSSSSSLSSNNLLANKDNSITSNNGSQPRRKVSTGSSSSKSSIEIRRALKENIDTSNNSNFNSPIHKIYKGISRNKDSDSEKREVLRNISINANHADNLLQQENKRLKRSLDDAITNENINSKNLEVFYHRPAPKPPVTKKVEIVEPAKSASLSNNRNIITVNDSQYEKIELLGRGGSSRVYKVKGSGNRVYALKRVSFDAFDDSSIDGFKGEIELLEKLKDQKRVIQLLDYEMGDGLLYLIMECGDHDLSQILNQRSGMPLDFNFVRFYTKEMLLCIKVVHDAGIVHSDLKPANFVLVKGILKIIDFGIANAVPEHTVNIYRETQIGTPNYMAPEALVAMNYTQNSENQHEGNKWKVGRPSDMWSCGCIIYQMIYGKPPYGSFQGQNRLLAIMNPDVKIPFPEHTSNNEKIPKSAIELMKACLYRNPDKRWTVDKVLSSTFLQPFMISGSIMEDLIRNAVRYGSEKPHISQDDLNDVVDTVLRKFADYKI
The following text describes a protein:
Function:
Promotes neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes and thus regulates SCF-type complex activity. Function promotes cell proliferation.
Subcellular Localization:
Cell membrane. Note=Predominantly localizes to the cell membrane in eye imaginal disk cells.
Sequence:
MGNCLKCFQSAAEQSMPTNASSPNSHNSNSNACQTATSLANCYESVGINPNANERCALETDELLSSRTPLKPAKANNCDTKRNSFKSLGLLNGSAPTMSDIITTAVQESMEVSHQTLSKLFDVYKDPDDEEMILTDGIERLCNDLNYQPDEFAILVLAWCLDASQMCRFTKVEFIEGLHKMRADTIDSIRVRLEQTIEMLKADAEMFKQLYRFTFRFGLEPDQRVLSLEMAIDLWKLVFTVQTPDLFSNWIHFLEKHPNIRRIPKDTWNMYLNFTEQCDIQNYDDTEAWPSLFDDFVDYEKSRALVSSGIHDDDNNNDDPLQSHVKAEDPGLVS
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MFRCSIMALSKVLLRGAPAASVPLVLSQHLSECRILTKAHSCLLFRSCNAELTLGDRQLCNFTFLGPYLRTQHSANDHCSAHFAEPRRGISCRSGVAQAGAPAGESRAESAARRDSRKHPLDKDDISTHPGSSATSAPDVTVIAKGDHLFFSESATSWESLGINPTVGEALQGAGFERPSRVQEAAIPKILEGRDVVVAAETGSGKTHTYLAPLIQVLLDGRQSGPAPSPATLTPATVASALAEGQEVRLPLWAQEESHRASAFVLVLCPNATLCQQVADMAHALKDPEGGSLLKIAVVAGGQQPPAFTPDIVVATPGGLLNMLYAFDRKRRRRTAFARDVRYVVVDEADMLLSGGFARDVAQLLLIFRQAEKDLSRRLETEPTAEAESHSPTGEDSEGASETRNERSWVEERGEEGAAESSAGGAEWEEDEREDRRRAQEGGIWDDDVLAAEGGPSVASRGGPAGASSARRRERRRKVWVRSKQFIFVAATLPDSGKMSVGAMLRKQFPEAAYVRGGLLHQHNPRLQLAWAEIGRENRVAALMEAVAGPDWQEGRLRPLEERTLVFANSTDAAKAVSKLLTSQGLSPLKYHSGQTPTDKAAAIRRFSEQGGVLVCTDAAARGLDVPDVGHVIQAEFATSAIDFLHRIGRSARAGRAGRVTSFFTEDRRDLVEAVREAVEAQEPVEGAFSRKRSFRKKFKKYGVGRQGIPNQSVGRRTVGEDEMQRAQQRF
The following text describes a protein:
Function:
Binds and compacts DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation in vitro.
Subcellular Localization:
Cytoplasm. Chromosome.
Sequence:
MELPIAPIGRIIKDAGAERVSDDARITLAKILEEMGRDIASEAIKLARHAGRKTIKAEDIELAVRRFKK