lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a carrier protein that releases fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhances the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth (By similarity).
Miscellaneous:
MISCELLANEOUS: Expression is significantly up-regulated in skin papillomas and carcinomas.
Subcellular Localization:
Secreted, extracellular space. Cell membrane; Peripheral membrane protein. Note=Extracellular and plasma membrane-associated.
Sequence:
MRLHSLILLSFLLLATQAFSEKVRKRAKNAPHSTAEEGVEGSAPSLGKAQNKQRSRTSKSLTHGKFVTKDQATCRWAVTEEEQGISLKVQCTQADQEFSCVFAGDPTDCLKHDKDQIYWKQVARTLRKQKNICRNAKSVLKTRVCRKRFPESNLKLVNPNARGNTKPRKEKAEVSAREHNKVQEAVSTEPNRVKEDITLNPAATQTMAIRDPECLEDPDVLNQRKTALEFCGESWSSICTFFLNMLQATSC
The following text describes a protein:
Function:
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
Sequence:
MKYSGYHLVIDLFGCNFDQLENTEYIIEMLKKLARALDTKIVAKAFHKFHPQGFSGALIISESHITIHTWPEDAYIGIDIFTCSKCFDPRKIVAYLKENLIFKKVEIKEILRGKID
The following text describes a protein:
Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MANKDSREQQDAGSKRDESLSPLQLPAITGEEKDVATAAHSHFEAGNYNGCVEQVRKLANMRPTDPKVQHNLAVALFYQSGCRKVDEYRRSLGNVCSQVHVDLEQIDSLGDADQAIFFFNNAVLLHHLRQHHQAIRVLEKLFQVIEPLEEWVAVRILLLLIESYLITHQPDKALATLVYLEKLMQTSEAKKEAADKGKDSKDDEHRPVDTEKVKAKIHQFKTKCYLQLKHLKFCKREIKSVKTVMNSNGAQSPITLFLKANFEFERQNNRKAIKLLNSSPEGLDYNQMGQCIPVMYYNNLVSIHYAMHKYHLGAHYARRALQENATAVKELPKKSGRAIQTLGMNHHHELLYNTGIVLLHAGRPLAAFDCLVEAVQVFPTNPRLWLRLAECCIAANKTLSEGESKGGSKQSIVHSTIGTGSHRKFILSPGGLDTNYGTDIQPAAMPVASLEFASLCLSNALSLLPEKPGSVPTTPISSQNSVGSEASDAASKLSGPPTIPAPPGPPLKPTEVSNLRCSVMAATAYVSLSLGDDVTALEHARSLLGQPKLSGSLQFLARMYAAEALLKHDQIGEAIQLLNPETVCDVSVIITPTPDFGENKDRDRNEKSNNHDGGSSGGGGGGGGGNNNNTSDPNEGTEPRKVIHQYYPASIQVARAHMFFNLATTHVFRSEWDKARRCLQQGCSMVPVHDIPKQALYTAIYLELHTGNYSLALQMVKKQQLIPYIKITPVPFIEPINRPVPVPASSTPSGFPAPIGPPSTSRSSSSFGLPTPIGAGKPSANTWR
The following text describes a protein:
Function:
Probable transcription factor involved in plant development.
Subcellular Localization:
Nucleus.
Sequence:
MGSYSAGFPGSLDWFDFPGLGNGSYLNDQPLLDIGSVPPPLDPYPQQNLASADADFSDSVLKYISQVLMEEDMEDKPCMFHDALSLQAAEKSLYEALGEKYPVDDSDQPLTTTTSLAQLVSSPGGSSYASSTTTTSSDSQWSFDCLENNRPSSWLQTPIPSNFIFQSTSTRASSGNAVFGSSFSGDLVSNMFNDTDLALQFKKGMEEASKFLPKSSQLVIDNSVPNRLTGKKSHWREEEHLTEERSKKQSAIYVDETDELTDMFDNILIFGEAKEQPVCILNESFPKEPAKASTFSKSPKGEKPEASGNSYTKETPDLRTMLVSCAQAVSINDRRTADELLSRIRQHSSSYGDGTERLAHYFANSLEARLAGIGTQVYTALSSKKTSTSDMLKAYQTYISVCPFKKIAIIFANHSIMRLASSANAKTIHIIDFGISDGFQWPSLIHRLAWRRGSSCKLRITGIELPQRGFRPAEGVIETGRRLAKYCQKFNIPFEYNAIAQKWESIKLEDLKLKEGEFVAVNSLFRFRNLLDETVAVHSPRDTVLKLIRKIKPDVFIPGILSGSYNAPFFVTRFREVLFHYSSLFDMCDTNLTREDPMRVMFEKEFYGREIMNVVACEGTERVERPESYKQWQARAMRAGFRQIPLEKELVQKLKLMVESGYKPKEFDVDQDCHWLLQGWKGRIVYGSSIWVPL
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGISGLLPALSPVTKAIHVKDYANKRVAIDGYSWLHKGAYSCSQEIVLGIPTRNYINYFISRIKMLISYKVIPVVIFDGGPLPNKKLKEQERLRHREEYKNKAKAYLLEGNKSQANICFQKAVDITPRMAFLLIKELRALKVEYLVAPYEADAQLTYLSITGQVDAIITEDSDLVAFGATHIIFKMDKYGYAQEIKTEDLGSCKKDGYDFIDFNQTMLRQMCILSGCDYLPSLSGMGLKTSFKLLKQHRDIEKVFKYLKREKSNFSQEYEQQFYKADFTFKHQRVFDPVSRILTTLLPLPTIIDSRFLNDNNNNTNDGDSNGDGSSGGSGSGGGFLDFIGPVIDDEIAEKIALGIIDPETHEQFDKTQPYPKNTFTPQPKKLLSPISFNTKEFKNQTNNNNNNNNNIKSNNGTNNKNGMILNEGKLVQKGRNLNDQFTFASNKITQYMTTTTTTTTTTTTTKNNNNNQKQQPMIEDDTGYDFQIDSFEIDDCLNDDDDDESIILSNNLNNQENVLESDCEFDDDDDQRGIDVDDSEKKDSFVLDSDYEDEKEEEEVKSSTFNSSSSISSGNSSKIKKTLVSSKFFVSSESSVLESDDDDGGDDDDDSFNHNQNFSSSGNNIQPNSNIFHNGELSSYGYQKNQKNFKNVNSNSSSNSSNSSNSSSGNSNSGNRIFNSGNSSNKNNTNGGIVKSTLLSSNDRVSLNFFDQFQFDGKKKQSILVSQSRKSFSSPTLSNNEDYDSSFVSSTIPSSIGDDYDQMNSCSNNNNFNYNNSSNFNNNNINNSNNNRNSGFSGFLKRKSSSQTAAPTTPTTPTTPKTSSSSSSTLTNSTITTEHSSYILKKPKYQATSNSPISTLDSSQNYNDQSFISKKAHSFSSLDSDLIFKEDDVDNLIFNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDNNNKITTPSNKSFNSIVLTTTSATTSITQQDNEIYTTPKKKLPSTPISSSSNDIISKYFSSPSKVGPKSEGAPPTPVNLEGMSLRSVLSLRYQQTMASSPTK
The following text describes a protein:
Function:
May act as a GTPase-activating protein for Rab family protein(s).
Sequence:
MSAAVEVAKEELKEVNICDICPEEESGVFLSAGASYLDGFSGFHKWVSKIEVSDGDCEKTSSRKAHEEEKGGLYFDREELKDSRASSLVDCLLVELYDTYSHGVPGLDSSTEASSSDAFLGRSNSGSSFLQELQEKHTRRHQVKYLAQKGPEELKWIVQEVKYRIAVQSAKLVRQAKRKDRLRQKFQKNCDIVTACLQAVSQKRRVDTRLKFTIEPSLGKNGFQQWYDALKAVARLPVGIPKEWRKRVWLTLADQYLHSISIDWEKTMRFAFNDRSNPDDDSLGIQIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNVLAALILEVTEGNEGDALKVMIYLIDKVLPDSYFANNLRALSVDMAVFRDLLRLKLPELSQHLHHLQKVANREAGGSYEPPLTNVFTMQWFLTMFATCLPHHTVLKIWDSVFFEGSEMLLRVALAIWAKLGERIEECQTADEFYSIMGCLTQEMLEHKLIDSNELMQTVYSMAPFPFPQLAELREKYTYNITPFPAPVRANSSLALHGWESDDDADMDDEDSIVTALGCLGPLGGLLAPEIQRYQRHLKDQRAEQSCNGSNMAELSPGAVGAGRAEHQAAINSMMLERMSTDISALKKQYSRIKQKQQQQAGLLYIHTGLPVEAETIEPHQSSKQQIYHTDKCPATSVLASQIGPSPVVNHLLLGRRPRPCERSLKNGMIHNGGSPQSHSTPLLDQMVRSRHHSPWRTHVRAHRRNIARARAQLGFDDSLEAEDDQTDESKTEGASMEGEETKSEEADEDKIENTAAGGSDVSKQELQEIDRQLSALELDPESSPDPSTPEPALDPDPQSDPTITPEPQADPNPTTPDPDPTIQDPSFTIQNPNSTIQNPSPTIQESKPTTKDSCFTIQNPNSIVQSPSSAVQNPSLAIQNPNTIVQNPNSSIQNPNPTIQDPNPTDQNPNSSIQNLNITIQDVNPTTPPQAPLTSSRRPGSDSSSSESGSSLRRSASSLAGDPPKAQQQIYSPFPCIKTPRKSTAARNLGLYGPTARTPNVHFPQMSRSMNRVGNTTKRR
The following text describes a protein:
Function:
Low affinity thiamine transporter responsible for intake of thiamine. It is possible that the primary function is the uptake of closely related compounds and that thiamine transport is a secondary activity of these proteins.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSFGTRISRALRFLEIPVKNRASVNFLRNPDLQPIKSVNQTWGFWSNFAYWGVLSFNVGMWIGGSSALTVGLSYSETIGAFIIADLLTILFALANSCPGYDWKVGFTLAQRFVFGIYGSALGIIIRILMSIVYYGSNAWLGGLCVNMILDSWSHHYLHLPNTLSSKVAMTTKELIGFIIFHILTAFCYFMKPYHMNYILIWSCVGTFFAMLGMVIYLTKSAHGVGDLFTSTHSTVTGSKKAWAWVYTISYWYGSVSPGCTNQSDFSRFGSSNCAIWTGTIVALLIPATLIPVFGIIGASACEKLYGQTFWMPMDIFDNWLTTNYSAGARAATFFCGFCFVMSQISYTISNCGFASGMDLAGLLPKYVDIKRGAIFAACVSWACLPWNFYNSSSTFLTVMSSFGVVMTPIITVMICDNFLIRKRQYSVTNAFVLKGEYYFTKGVNWRAIVAWVCGMAPGLPGIAWEVNNDYFHNTGIINFFYGDSFFSFLISFFVYWGLCLLFPFKITVKHDDKDYYGAFTDEEARKKGMVPYSEISEEEIRAYTLGECFTSGHEYKPESSDDELPELTKTSSENTKVFEIVHQKDNEKESSTSSEKQIA
The following text describes a protein:
Function:
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Mainly localizes with heterochromatin (By similarity). Associates with actively transcribed chromatin and not heterochromatin (By similarity).
Domain:
The C-terminal domain is required for high-affinity binding to chromatin.
Sequence:
MSETAPAETTAPAPVEKSPAKKKTKKAGAAKRKATGPPVSELITKAVSASKERGGVSLPALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKVASGEAKPKAKKTGAAKAKKPTGATPKKPKKTAGAKKTVKKTPKKAKKPAAAGVKKVTKSPKKAKAAAKPKKATKSPARPKAVKSKASKPKVTKPKAAKPKAAKVKKAVSKKK
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKSALQIARAAYQPKLPKALATGAVKAVAGAATQSVADQEAIKALFPNTYGMPLITFEAGEAVQLPAMNVGVILSGGQAPGGHNVISGLFDGIKKLNPESKLYGFILGPGGLVDHNYMELTADIIDEYRNTGGFDIIGSGRTKLETEAQFEKGFEIIKELGIKALVIIGGDDSNTNACVLAEYYAAKKYGVQVIGCPKTIDGDLKNDMIETSFGFDTACKTYAEVIGNIQRDCNSARKYWHFIKLMGRSASHIALECALQVQPNVCIVSEEVEEKDMSLDDVVTSIAKVVADRAAQGNNFGTVLIPEGLVEFIPAMKRLIAELNDFLAANAEEFSQIKKSHQRDYIIRKLSPENSAIYASLPEGVARQLTLDRDPHGNVQVSLIETEKLLSEMVATKLAAWKEDGKYVGKFAAQHHFFGYEGRCAAPSNFDADYCYSLGYTASMLIADGKTGYMSSVRNTTAPAAEWIAGGVPITMMMNMERRHGEMKPVIQKALVKLDGAPFKAFAAQRDRWAVETDYVYPGPIQYFGPTEVCDQATKTLQLEQAK
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in maltose transport. MalX can also recognize and transport glucose even though this sugar may not represent the natural substrate of the system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The EIIC domain type-1 forms the PTS system translocation channel and contains the specific substrate-binding site; The PTS EIIB type-1 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-1 domain.
Sequence:
MTAKTAPKVTLWEFFQQLGKTFMLPVALLSFCGIMLGIGSSLSSHDVITLIPVLGNPVLQAIFTWMSKIGSFAFSFLPVMFCIAIPLGLARENKGVAAFAGFIGYAVMNLAVNFWLTNKGILPTTDAAVLKANNIQSILGIQSIDTGILGAVIAGIIVWMLHERFHNIRLPDALAFFGGTRFVPIISSLVMGLVGLVIPLVWPIFAMGISGLGHMINSAGDFGPMLFGTGERLLLPFGLHHILVALIRFTDAGGTQEVCGQTVSGALTIFQAQLSCPTTHGFSESATRFLSQGKMPAFLGGLPGAALAMYHCARPENRHKIKGLLISGLIACVVGGTTEPLEFLFLFVAPVLYVIHALLTGLGFTVMSVLGVTIGNTDGNIIDFVVFGILHGLSTKWYMVPVVAAIWFVVYYVIFRFAITRFNLKTPGRDSEVASSIEKAVAGAPGKSGYNVPAILEALGGADNIVSLDNCITRLRLSVKDMSLVNVQALKDNRAIGVVQLNQHNLQVVIGPQVQSVKDEMAGLMHTVQA
The following text describes a protein:
Function:
Part of the ABC transporter complex MolBCA involved in molybdate import. Functions as a low-affinity molybdate transporter. Binds to both molybdate and tungstate, but not to sulfate or phosphate.
Subcellular Localization:
Periplasm.
Domain:
Nucleotide binding is coupled to a conformational shift at the periplasmic gate. This shift is akin to unlocking a swinging door: allowing just enough space for molybdate to slip into the cell. The lower cytoplasmic gate, identified as gate I, remains open throughout the MolBC-A mechanism, and cytoplasmic gate II closes in the presence of nucleotide.
Sequence:
MKLKSLLIACLLSSLSFSALADRIITDQLDRKVTIPDHINRAVVLQHQTLNIAVQLDATKQIVGVLSNWKKQLGKNYVRLAPELENMAMPGDLNSVNIESLLALKPDVVFVTNYAPSEMIKQISDVNIPVVAISLRTGEVGEKGKLNPTLTDEDKAYNDGLKQGIELIAEVFEKKQQGDELVKAAFANRKLLADRLGDVSADKRVRTYMANPDLGTYGSGKYTGLMMEHAGAYNVAAATIKGFKQVSLENVLEWNPAVILVQDRYPDVVPQILNDQGWANIQALKDKKVFLMPEYAKAWGYPMPEALALGEVWLAKALYPQRFQDVDLDKMVNDYYQKFYRTSYKPDNAAR
The following text describes a protein:
Function:
Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
Subcellular Localization:
Nucleus.
Sequence:
MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDAWGQPSRTGPLDSVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHPPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLHSNMFMFRASLDLKLIFLDSRVTELTGYEPQDLIEKTLYHHVHGCDTFHLRYAHHLLLVKGQVTTKYYRLLSKLGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTDVEYKELQLSLDQVSTSKSQESWRTTLSTSQETRKSAKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECSQVGNWRTSPPTNAVAPPEQQLHSEASDLLYGPPYSLPFSYHYGHFPLDSHVFSSKKPGLPAKFGQPQGSPCEVARFFLSTLPASSECQWHCANSLVPSSSSPAKNLSEPSPVNAARHGLVPNYEAPSAAARRFCEDPAPPSFPSCGHYREEPALGPAKAPRQASRDAARLALARAPPECCAPPAPEPQAPAQLPFVLLNYHRVLARRGPLGSAAPGAPEAAGSLRPRHPGPVAASAPGAPRPHYLGASVIITNGR
The following text describes a protein:
Function:
Exhibits oxidase-like and peroxidase-like activities in vitro.
Miscellaneous:
MISCELLANEOUS: The name 'symerythrin' reflects the protein's high level of internal symmetry.
Subcellular Localization:
Plastid, cyanelle.
Sequence:
MGLNYNQEDFMGLDRFFQDAVSHNNTDANAASSIEVEMYECDCMYPTFAEIARRSGQPEIGAMFDAIAKEEGMHAQLLTKLYSELEVKDSAETLEAKRLVSTIESQIDAVASDSRGLRRALETALEVETIESQKTYPAFAKLAAEQGNMEVATAFEAIVKSETKHANWVKRALENLLEVA
The following text describes a protein:
Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
Miscellaneous:
MISCELLANEOUS: Present with 892 molecules/cell in log phase SD medium.
Sequence:
MHHNSQSLSSGHIRSPEDENVAPIGNLKHRTGSLSHISSAHPRVALSDVTNIVATNSSNNSISKPKVAPIKERLDSAAIIEEERLDANSVAQRKEADHNDLLTDREQEEPVEDDGESEEDEEEDQEPLLLQHYASDTLVWEHAFRTYYRTTLDPNDDDVYDVVMVAELSNEIFEYMRKLEDLYKPNPYYMDKQPELRWSFRSTLIDWIVQVHEKFQLLPETLYLCINIIDRYLCKEVVPVNKFQLVGAASLFIAAKYEEINCPTIKDFVYMSENCYSRNDLLDAERTILNGLEFELGWPGPMSFLRRISKADDYEHDTRTLAKYLLESTIMDHRLVSAQPSWLAAGAYFLSKIILGQNQWSLAHVYYSNYTQEQILPLATIILENCRYASKRHNAIWRKYSSRRYLHSSQIVAKWIALAEHRVERSN
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.
Subcellular Localization:
Cytoplasm.
Sequence:
VVAFPTETVYGLAANALDAAAVQGIFSAKQRPSDNPLIVHVSSIQMLESLLPPSLPHLPSIYVALINKFWPGPLTILLPKGPHIPNLVTASHDTVAVRMPSHPVALGLIAQCGFPLAAPSANTSGRPSPTLAEHVFADLHSRIPMIVDGGMCRSGLESTVVDALRNPPAILRPGGITFEQIRLIAGFENVTIYNTHFVDKGLEEAPTTPGMKYRHYTPNAEVVLIEIGANAIKLDETNCVDPECTRVGVLRAGSTIDKYDVCKEAVEIHLGATAEEIARNLFKGLRDLEQHYCACIIVEGIPDVGHGLAVMNRIRKASTHIIQP
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLYGYLTLLVLRLHFHTAQCIGFVPLHFNKQLQTFQISRWLTVWSHALALTLLCVYPYVYVILLTGIRYPKLTLVNYLVWMQCSLHYVNLALIYYHLLPARPVIRNIFNGFVQLFRTLNGAGCHRWKGKSTKKNVLKLALKMILCDTLLCALFVLYFGQFFIQDGDIQSQILWTLNIFSVWQSAIFTNLIVVTLIIGVHFLEILNHRLTLYIRQMRAPACHLKQLRRQISTYEALKSVQRNHHLVSSNVKSFIHLQRSTDTVSNKLIVISFRYNAPTQIFYAYTSIVQDIKNDVDVPLGTYMSSILFAVFEAVQFYYIVSASSEITEEVRKHAEKTGVLLNEFLPTDPNPRVERCIESFAIELLHEDFKINNCGMYDVDYTLMFSMIATITSYLIMLVQFQLAEI
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MFTGVRRFDPTQGGQASPVPFKKVKHEEEESKPETNADEHSEVEYEEESGDDSMDEAEEAKKPVEVKDEEESEDENLTADQKRKKKQEAANLAKRAEEKALERKRKREQHMGEEDSDSEDDLAPIKISGNNKIKLAKGTIRAKGFEELPQTEIYEDKPDESATISRKTQLQTQPILRNATYVEIDDVGSFDEFDLSKNMMKNLDTLGYTKAFSVQKAVIPWLLAQQKLLAPDRKPDLLVSASTGSGKTATYGIPIIEKLRDRIVPRIRAVVVLPTKPLVMQVRDVLENLSKGSSLSVVALRNDRSTKRERAVLETADIVVAAPGRLVEQVKENPELFSYIEFLVVDEADRLLGQDYYDWASVLQNNQQRAQAGKTNLTEHYVRNMQTLIFSATLTANPEHIASMDIHNPGVFVIGSSDSYSIPKSLTEIVTHVSAAEKPLMLCELLVQRDINRGVVFTKSSETAARVARMMEIMDADIFHKDWKIAAVSAETSSVHRRRSMKQFIDGKIDFLVCTDLVSRGIDFVVDNVINYDIPSGKREYVHRVGRTARAGREGNAYTFLTGSGEAKWFREIGEFVGRTQEVDATHINSSHNDGYQEALAKLEEEV
The following text describes a protein:
Function:
Required for pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSRSALTRHALQKSLRGQSALEQPPEETQRRVKQDELAVYGNDTTYNLNTLLHQNILQSAYFHDLYKLKTYHEVVDEIYYRVDHAEPWSPGTARIPSSCFCLLHKFFLMRLTRKQMQGLLRHTDSPYIRVVGFLYLRFAFDPDELWTWFEPFLEDPEEFNASANTSLKTTIGEWLISLLEENNYFGTILPRIPKKIEDGIKVKLLLFSRKKERAKENLAIVDRLKPGTKVRAMYADEENEPAMYDAVVDSVEEGNKFWVSFPAYGNTEKVGLGDIEFDKASRGRRRSNRSRSRSRTRSKAGGSDITGDLLQQVRERERRKAEAVGRDYASRPASYKGSLSLKLDRWTTRKRSRSPAKRDEVVVVQPGMSKGDEQRRSSSPSPEKAREAEKRLKKLRAMYGDASATTKDE
The following text describes a protein:
Function:
Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.
Sequence:
MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDHYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
The following text describes a protein:
Function:
First enzyme in the biosynthesis of tetrahydrobiopterin (BH4). Catalyzes the conversion of GTP into dihydroneopterin triphosphate (7,8-dihydroneopterin 3'-triphosphate), which is subsequently catalyzed by 6-pyruvoyltetrahydropterin synthase (ptsA) and sepiapterin reductase (sprA).
Sequence:
MSDNLKSYQDNHIENEDEEIYERSNGKGKELVDFGKKREPLIHNHEVLNTMQSSVKTLLSSLGEDPDREGLLKTPLRMSKALLFFTQGYEQSVDEVIGEAIFNENHHEMVVVRDIDIFSLCEHHMVPFHGKCHIGYIPDQKVLGLSKLARVAEIFARRLQVQERLTRQIAQAIQAHLNPMGVAVVIEASHMCMVMRGVQKPGASTVTSSVCGIFEKDSRTRAEFFSLIKSNK
The following text describes a protein:
Function:
Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.
Sequence:
MSDWESHTVIGQKARAGGSGPRANVARTQGQINAARRQGLVLSVDKKYGTANTKGDAEGQRLTKVDRETDIVKPKKLDANVGKTIARVRTEKKMSQKDLATKINEKPTVINDYEAGRAIPNQQVLGKMERALGVKLRGKAIGEPLGGPKKK
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. Regulates trichome branch positioning and expansion.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Domain:
Activates the Arp2/3 complex and binds actin through the C-terminal VCA (verprolin homology/cofilin homology/acidic) domain consisting of a WH2 domain followed by an Arp2/3-binding acidic motif (A), separated by a conserved linker region (C). Binds BRK1 through the N-terminal Scar homology domain (SHD).
Sequence:
MALTRYQIRNEYGLADKELYQSADKEDPEALLEAASMAGLVGVLRQLGDLSEFAAEVFHCLHEQLMTTAARGHGLAMRLQHLEADFPSVEIPILSQTDHSTFFYEPGLEWHSDLQTKEDLISPRNLPRCIMDSYEECHGPPQLFLLDKFDVAGSGSCLKRYSDPSLLKTHTTSAVVATSKLGKDKRLRQSKKKGSHTTIKETPEDSRTSHAKLHQLFFLEHVENGHRNPEFHVKLKRRQLNGPPINSSSGASYMEKFLKNSSPYCERVHGTMDQSSPAMETEVTVCSEQEDLPIPSLVYSNSGGTRKYNEMEIESIAGHEILEIPFVPHEITVNEKSPVVCLESSSSVNLCCKTNNDADSPASTESEVKEAGSDDKAGCDHGFPGFGQPQICTNAEVNQTEVLTQFSNVLRHSPEEGESSLLCTDIQRASPESKPHKAEEAAVDLDESFSQMTPDIDSAGMGTLEILQTPFSLSCYESPANLPEDSGSHLELQSNKANAEACEVFEVRRDPMLNISPETHLLKVTQVPQDAYEGGTNDVHSQHVFSVETASEISVSALVEDQFSSITNQEIEALESEDISSEAGHFIPDTKKSLNETSVALESDFLLPNHYISTFDNFEDLSLSADAQDYAAPKEDETNSQDGSSMNPAQSKHISTSEISSENGTLMSDTPRDLHTGYGSLSASSCLEDGLANPDLAEISSYSGQEDPQTMSIVSDDSSDPEVPIPDGTCFAGDVDHDNQTGLNNKAIETVPQKELETISDPQESLLGTEECLSSEYCLQIQNQRQESPSETGSANSRTSSDESPPTQNGSVGVQSSPLDVFPSSITEIEALHAPYQEIFTSLNDHISESVLSKGLTDEEDFLNVSPESILPLSTSLHETPQANPEITPPLPPLPPTQWWMGKLVESTEMPSLAGSGNNSFNIQRDENTQNGSVQANEAQYPSEVSVTDGENHNFHIYTEESKATEEQSPSGVNGTSDTYMESKHKCLNRTPEDSFSLAESAQGLEADWRTEAMALEWFSQNLREHNNPHPAKLEEEEPQVDHPLEKPGQTKFRQTLRDNNSYNQNQKAGKLKRDEDTLVIGIDRSMLRKVSEGNRTHVGARVDENDSLLEIIRSKSFNLRPADASGRPNFQVAVPKTNLKVAAILEKANTLRQAMAGSDDEHDSDSWSE
The following text describes a protein:
Function:
Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A. Acts as a transcription regulator of CIITA, the major factor regulating MHC class II gene expression. In addition, regulates cellular m6A/m6Am methylation on RNA by facilitating the recruitment of the RNA demethylase, FTO, to target mRNAs.
Subcellular Localization:
Chromosome, telomere. Nucleus.
Sequence:
MDGSFVQHSVRVLQELNKQRERGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGSVVLPAGFAEIFGLLLDFFYTGHLALTSGNRDQVLLAARELRVPEAVELCQSFKPKTSVGQVPSGQSGLGKAGPRDVNSHLKEPAGLEEEDVSRTLGQVPRDQELSGSPSPQRPQLGLPAQSENPSFLRGKLKQALKLHPSEDKEPEDCKVPPRPFEAEGVQLQGGSNEWEVVVQVEDDGDGDYVSETETEAVPTRRKSNVVRKPCAAEPALSTGSLAAEPAEDRKGTAVPVECPTCHKKFLSKYYLKVHNRKHTGEKPFECPKCGKCYFRKENLLEHEARNCMNRSEQVFTCSVCQETFRRRMELRVHAVSHTGEMPYKCSSCAQQFMQKKDLQSHMIKLHGAPKPHACPTCAKCFLSRTELQLHEAFKHRGEKLFVCEECGHRASSRNGLQMHIKAKHRNERPYVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHLCGKTFRTQASLDKHNRTHTGERPFSCEFCEQRFTEKGPLLRHVASRHQEGRPHFCQICGKTFKAVEQLRVHVRRHKGVRKFECTECGYKFTRQAHLRRHMEIHDRVENYNPRQRKLRNLVIEDEKMVVVALQPPASWRWAQPRSSWSHWPRAAWPPSSLARDCVRRRASQARASWSPRSSSRPPSPRTVTHSPLPASARWAPVPNKPRDFGL
The following text describes a protein:
Function:
Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression.
Subcellular Localization:
Nucleus.
Sequence:
MNSPQDYQTDLEVILEFLEEHYRQESHRKALWDMTDLSVTSSSGSVDTSAEKRPDEENFIKVSGQETQVMESLPKANISDGRGINTLKAAESPLILHATPEKRVKSLPSSTTAEKGKKLRLFHFLFEMLEDPDMAHCVSWVPASVGVFCFSAKNKEHVAELWGQRKGNRMPMTYQKMSRALRNYSRSGEIIKVKKKLTYQFSVTTLSTLQSQRGAKKAA