lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.
Subcellular Localization:
Nucleus. Note=Nuclear rim.
Sequence:
MNELKHAVVPIDLQSFCLEGTLALWVPALENDSEDDSEAIETADDNEKLFKKECVAYDAGVYTSNKSKGSQTLRWSIFQNRTLTIFDVSLNSKKEPLSKFNVKIHFPSNVMKDGVAFSFSEHSDTTIIYAITHARVLYYIRLSKTWFQLPDARLDDDWCLCYRPISFLNQKPDLMAAISTSEICVSFFNGGLTKIILNPKDASHYEQHIDDSSYLFSLKKYLSLQAFKADYRSPNTIISMIFLSTYNVLVMLSLDYKLKVLDLSTNQCVETIELSQTILPLQSFPYLTSDHTTNSFIALYYPDNSHGSFSIYKLNANAHSFKLNVVIEKGIIPPSLPDDEFIPWMLSDFQLISSEGSQSKFLLIIAWKSNLNTVIQKCNLSLDQDESFSCVWSHSLDSFSLIEKTFFDVPTNMSSGDISEIWLQHIFAHNTSIESIQVALLSFQNSSSQVSKNKLDKFGALTISELKNAVLSSIVSTIQIEPNSDLTGYDYYEYKRLLYNEWERFAKLVAYLDHFGDEILSINFDPSNAVTYINYANKVAFIRDPYLIESFDEEPLTKLISSLETDDPSLIEGYQILDLGRSLHSCMSFSTLSEIRYSLRELVQDLPSYSLFDTLWVFYDKHIYPNVDPDYISTLIDTLVSLENPMRDIDSLIQRLRSFDIYNHSAQSPSLFLCASVARVLDSILKKFQVSIEGFIFLLSLITSQQDYELQSKFAGCDKLFLSLLEDWRLVSFLLENSALLLEKFEEEDVDSTNCNLNTMEALASVNTALQFFSALNYSECFSESQISPLHATVISSLSAIFIRDDTENDLVTELVEKLFLFKQYNACMQLIGWLNSDPIAVYLKALIYLKSKEAVKAVRCFKTTSLVLYSHTSQFAVLREFQEIAEKYHHQNLLSCYYLHLSKKLFEESAYIDALEFSLLADASKETDDEDLSIAITHETLKTACAAGKFDAAHVALMVLSTTPLKKSCLLDFVNQLTKQGKINQLLNYSMPTLRQDVDNLLERKAFQMINVESQPCWYNILFSWRYKHQNYRDAAAIIYEKLSRYISTTELIGKKERTFIIEHYLIVLNTLELLPKEDTWILVTDMSVDKEPDPNFLPQKLLTLDAIVAEYHLQLKDVAVQVTAEMSSAMNIDL
The following text describes a protein:
Function:
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Sequence:
MKGMKEYIKKLEEGSDLSSEEAEAAIGEILSTAEDEEIGAFLLALRAKGEKPQEIAGFVRGMKQAGNTIKPVTPFRVIDTCGTGGDGLNTINVSTAAAIVTAAAGVPVAKHGNRAATSMSGSSDVLEALGIKVDLTPGQVRKTIEKIGIGFMFAPVFHPAMKRVAGVRKKLGVRTVFNILGPLTNPAGAKGQVVGVFDKKLCEPIAYALAELGTEHALVVHGDGMDEISNTGETFVAELKDGEVSTYTITPEAMGMLRAKPEDIKGGTPKENARDLLCIFKGQKGPKRDLVILNAAAALYVSGIVGSIRQAIPIAEDAIDSGKVMVKFNQFRNFTAELSIQGKKEGSCPGEAFLASSDTSVLSPASGEKA
The following text describes a protein:
Function:
Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum. Golgi apparatus. Mitochondrion.
Sequence:
MAAGALAHAPELRVLLFGKSQNKKNMLSNLITGKKDFFLSKLSPNTTITKGLFQNTNVTVVNTADIFSQSQEKVKHEMKKCVALCPPGPNILLLMVKPHDFNEDDRQRLKFIQSFFGPEAGKHSIVIFLNKEEPKTPSINKLKQDCGGRMQIVHFDRQDLLNKDIKELMDKMTAIVSNTRQSHLNFSEGLETNKRTSATFQPPLNIVLCGRHGIWKSSVADVIMGKNNQQALDTRHAKREAEVSGRLVSLIEMSALYGNSPQVTGKITQASLSLWNPEGVHAFVMVLPVESISDKDKKELEVLQEIFGSQFKAFTVILFAVESDPADAEVVSSMTENKKIQELRQSWPGQYMVFNVKDKQQVSGLLSLVEKISAVGSQSFRREMMIKPRTIQKQDIQMTTTDGKLKPEPLRIVMVGKTGCGKSATGNTILGKNCFNSKPSMKSVTTLCKKQSAEVDGRMVSVVDTPGLYDTNLSNDEVKQEMVKCISLMAPGPHVFLLVVQVGRFTQEERDTVDLIREFFGKNSVHFIILVFTRGDDLQDQTIESYIEEANDKFMKELIESCGGRYHVLNNKDQKNHQQVAALLNKIDTMVKKNGASCYTSEMFQEAERAIQKEVQRILKEKEEEMQREKEKLQKEFEKEIEAKKMKIQEERTEKEKALREKEEYIKQQEQKKKKEEEEREKEDKNQKIKEQHLRREWSQKLKSLEEKMKSELERNAVSDKDIITYKEELQQERESWERERKQWWQKRKEEEQQRQEQERAQLQKLKEEYDRERSDYEIKRREEDKIRKAQEEKELRETQESYLKKMEEIKERNEEEARKQAEEFNEFKEKYVKDFTALMAKHDKEIEELKEKEQKKNKIILKNLIKDKTYKKQYELLKKKQDEEKSDLQEKLSQVDEEARNEATSQLQVKHDEELNEWIEKQMQSASDKNCTIL
The following text describes a protein:
Function:
Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.
Sequence:
MASLLNQLRGLTTVDCDTLDAHVARIYGPFADCTSNQAIVLAEITKLDANGKLIYQTLIDEIIPIAHWMFGNQTDATVEELASELLAVGLALRFIPHLNGFIHIQTNPKWCYSTEKTVKNAERIVAHLKHLAPDFDTSRICIKIPATWEGLQACRELERRHSIATLATIVFSMEQVALAVDAGCRYVAPYVNELRVHFDATYTDANKDRAALFCGAAQRYCDEVASSASAAEAAHGSLNLQMQTQVMAASLTSVEEVMRLAGAVKHITVSPPLLMELEATPAAGWPGASTVGAAAAITGSRVNGDAVRLRELVRDQSQWRLAFTRAEAGESERKLGQAIGIFCDMQDQLERLVRRWDLTGKKYARG
The following text describes a protein:
Function:
Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
Sequence:
MVDGANGSFSPGEEQIPYPDLQHGTDTTAAPSRPRRATGWLSLLLTGSRRLSPSVCGTASGRPSRWGNSRTPATQASPRAPLSRRRPFPPSSLSPTTPPPSTTWHIGVRVKATKKLSNFLCVHNRLRSKRLAPVMIKEVTRRVHLENIWPAAYTAGVVLPTPFTTFRYWHRSLNPKKLIDVVFSRLGARMTMSRTIRLDKLPVSTTTTGLRKMELRNVPTVTRLLREYLSQYVVAPDLDETDVDLMQLIEDYFCQYCDKLCFIYLCVNRISQEYRKIGKMYIFERSNWRTNKSSTWHQKECVIPTSKEKKQSSRQAKSIYNPIKQNLCQNCPFTTLS
The following text describes a protein:
Function:
Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle.
Sequence:
MKSDQLGRVLSDDDLPTKLSIANEFKAFVKKNSVPRDLIHPYFLTLSRAIKSREDPQLTSVCFSCFCHLFKRVSIQDKQLLDDSATVAVVTDLLIDRLSDRSTGVRATANKVLLDYWVLVPQAVAVAMRQSAVVSSSHVTLGESLKWLQSVFDLSSAFNFSAFVQPVVDMLRYPQLQSSVCELLKKVYSVSDRRELEECLAATGVNEMLKKSILNGLPGGNSSSAVSDPKTTAPRSLSSQKSVASKPAQQPNSQEPGNENAPSSSLAFLNSLPNFRVDSLAPENVYSASDLESKINNMHVAFADKESEKNWSLREKHVTQIRKLLRGNALQDYPSQFAAAYKSVIDGVLKSATSLRTTLSNQGLLLVKESGQLGGNAFVDPVMDIVFPQIIRLTGQMKKITSNNAHITVCGLLTSATFSTKLINHVTSATVEKNAQPRTFAAVWLRILILSHSQTHKSAMQNHGGLDQIEKAIAKGLQDPTPSVKENMRVTYWSFAEYWPSEADKIYRKLDTKAKAMLDKVNPSGAKNAPIKKPAPRESLKEVMRRSRESSVNRDANAPSATAPPQRAKMGAPQRTSSGLVGRSLSGSNLTDRSNRLSSTSTSSRDQQRAVSDSTRPTQMTRPVSGRLSREPSLTRSSRDQSLTRSSRETVSREPSLTRGSRELPKQRVDQNRQRVPSISRDSRYGQRPVGSRESSRQSRESSLDPSRESSLAPSVHSSTAISRESSLPRDDLPSYDVEMDEDDPFVTQQLKLSLKQEDAMSQPEETMNEVTTAEATATTAPMKIPKSTPPRESTPPNSSPFVLAKSPATQGVSTSPATGKSASPPATAEDELSRDLNGESKHLKEVDDDNGSMDADERIESDVVMGDAEESAANFEPSEVEPAGVQLGLKSPKRETPTSALQGNEQAEPESHDAVADSQSHGADSADLQSEPRNVPVSPPTTSDASNVPILSPRPIHPAKFELDSDAMIVDEVAPEVNTVIDAQTQAEETPTEEIPAVVKVGFDAEAKSEPTEQTEAVKTSDTATEPGEPVDIPNSEQGPSTEPTELAKSAGSVEHVTEAIQEDPFGDALPAKQENGAKASDEIETDHTKSNNTESDGPVSAHDESEPMEICDSDNDAVDNGTNPDTKCQDQQDSTTPPMDFSSHDLKDELNTSSPESLTALLSNPDQYKEILDHVPAELFLLCVILFSESHVMDAQSVISRDTNLALSTASSMVMVCARDVYPSDSRWSQATVEELKHVTVTCLEWLTKLVNESSEASTLLATNKRYRTSLVHLLSTSVELHKQKFGDVTHNSLIHVIESMDKLSQRPPDKRTSRAFLEAPSPSPDSSLVEDVTDKLSHVTVKENFKTIRILPPQLASGQLIFPGSEVTWSKLELERLARSPSCSDSNEAILDAVSRDKVSVTQLSTLASRIPELEDVDLVTATILAYLHISHPPALTTAALVAIKQVLIKPELKLSMGHVTEIFSTLNHVNSHIDSRSPLAAAIEELVADLLTHTDSSEMLEFLLLSRSRDSKTQNKLLLLNTVYHVITPDLLPSYETQLLALITELISDPDPLVRRVTVGLVVRVLRVSPEMEGTISLAIKSKMDLVRYYMGA
The following text describes a protein:
Function:
Catalyzes the prenylation of L-tryptophan at the C-7 position of the indole moiety. The enzyme is specific for dimethylallyl diphosphate (DMAPP) as prenyl donor. Also accepts D-tryptophan, typtophan-derivatives with modifications at the side chain or the indole ring, and linear and cyclic dipeptides such as H-L-Trp-L-Gly-OH or cyclo-L-Trp-L-Gly as substrates, however with lower efficiency. Also has tryptophan aminopeptidase activity towards linear peptides with a tryptophanyl moiety at the N-terminus. Dipeptides are better substrates than peptides with 3 or more amino acids. Enzymatic rate constants however are much higher for the prenyltransferase activity than for the aminopeptidase activity.
Sequence:
MSIGAEIDSLVPAPPGLNGTAAGYPAKTQKELSNGDFDAHDGLSLAQLTPYDVLTAALPLPAPASSTGFWWRETGPVMSKLLAKANYPLYTHYKYLMLYHTHILPLLGPRPPLENSTHPSPSNAPWRSFLTDDFTPLEPSWNVNGNSEAQSTIRLGIEPIGFEAGAAADPFNQAAVTQFMHSYEATEVGATLTLFEHFRNDMFVGPETYAALRAKIPEGEHTTQSFLAFDLDAGRVTTKAYFFPILMSLKTGQSTTKVVSDSILHLALKSEVWGVQTIAAMSVMEAWIGSYGGAAKTEMISVDCVNEADSRIKIYVRMPHTSLRKVKEAYCLGGRLTDENTKEGLKLLDELWRTVFGIDDEDAELPQNSHRTAGTIFNFELRPGKWFPEPKVYLPVRHYCESDMQIASRLQTFFGRLGWHNMEKDYCKHLEDLFPHHPLSSSTGTHTFLSFSYKKQKGVYMTMYYNLRVYST
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MGLLPDEARSLPPPGLVNRNSVWMGLMGYLTAITHNAIRHMPALRAGVHRQLLLTSIGVFLGYHATKYENYRNANTDRQLFEYIRQHPQDFKVPERKTMAEVLEEFTPIR
The following text describes a protein:
Function:
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MERTQSLPMTPPSALPVSPPCSPPPGVSKYVVGVCAMEKKTRSKPMREILRRLEKKRQFDVFVFDDDTILNRPVEAWPACDALISFYSTGFPLEKAEEYVRRVRPVLVNELGMQHVLFDRRKVYALLTRHGIQVPRHIIVNRDLPGGKQDELEEHDNYVEINGVRINKPFVEKPADAEDHNVYIYYPTSAGGGSKRLFRKVGDRSSEFYPDVNRVRRDGSYIYEEFLNTQGTDVKVYTVGSSYGHAEARKSPVLDGRVMRDSAGKEVRYPVILNSTEKEMARKVCLAVHQTVCGFDLLRMCPQYATEPSIMSNGAHDWREHTRPSSGSDASESSVASASSAGLLPDDENREELRCVIAVVRHGDRTPKQKLKTVVWERDLVDFYEKRRSEGKYDEVKVKAVADLQELLDLVRSLIKAYAPGVGSKEAVWEVEGGDSFEKLLQMKRVLERWKFAGINRKVQFKPHKSYAAAAAAFADDPEKAEKPKVLMILKWGGDLTERGKQQGEELGQSFRNSLYPVEVEEGGLLRLHSTFRHDLKIFTSDEGRVQMTAAAFAKGFLELEGDLTPILVSLVTTLGRGQADATEEMQTTKTKLRTLLQREYSSPEEMRAAIAPLKTESIIQALEIIKNPKEALARLLELVRKLRAEIAERVQDKQADETTPLYMGETFSLMFERWDKIFRDFYSTKTETFDLSKIPDVHDCIKYDLLHNSSVGWKCGHELFILAEALAGCYVSQEYGMDVAEKQSIGNRVSQALCAKIRADIVTVMSASANEQHGSSSSKSLFGGSNGDTAEDGAIGDIADQDIEHHGYRLDPSYAKELRIKSPGTQVRTRLYFTSESHLHTLLNVLRFQCPSWRARHQHGGEDDEYDISLEQEKFSNEILKRMGISVSDHMIQRKYVFRASKLISDSSRRALDRVAEINYLAHIVIRVFETPSLPEDSEDRFRVEISFSPGVKDGLANSSDGASGVADTIYLTKNMTGVMFEDMLAACVSSVQSTSV
The following text describes a protein:
Function:
Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.
Sequence:
MAMEQKNKSRFRRVCVFCGSSPGKKSSYQEAAVQLGKELVERDIDLVYGGGSVGLMGLVSQAVHDGGRHVLGVIPKTLMPREITGKPVGEVRAVSDMHQRKAEMARRADAFIALPGGYGTLEELLEVITWAQLGIHTKPVGLLNVDGYYNSLLSFVDQAVDEGFISPDARDIIVSAPTANDLFRKLEEYVPKRDDRASQLIWEIEELAYEPDSNVAAT
The following text describes a protein:
Function:
Acetyltransferase enzyme (By similarity). Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. In differentiated cells, negatively regulates localization of heterochromatin to the nuclear periphery. Plays a role in migration of gonadal distal tip cells, where it probably modulates expression of genes involved in integrin-mediated adhesion.
Subcellular Localization:
Nucleus.
Sequence:
MDEPPSKKSRADSDYDSGLDALSALESLEAFPTSSKDTDVDNNPSTSAGGSGGPSGSTPHPQGTPQPAPSNNGGFNLQPGQSQPQQPPQNMGGGVNGSVLQELLMNPSQTSNNSPRPQAYPPGQQNAFNRSPMMPNGTPNMMSPPSMGRVPGPSPGGPQPPGPGQPQMRPGQPGMFQGDQQQQMMMGAQGQQFPGMMHRYPYAQGGPPPGAQGMPQGYPGVSRGGPTPGQPMGRGAMMNGAMPRSGPMPTQGRPGIPPNQQAMMQPMMTDRQFMQHGQYGQQRPEFMQQYGRPGGYPMMHQGMMMDSNGQPIRGPNQMMMMSNGHPGMSHGPPNGQPGPQAAAAQHAAQQQAAAQAQAQAAAQQQQQQQREQEAAAAAQRNGAGRATTPGSSMLATHQDPEKRKLIQQQLVLLLHAHKCSQREKENRDFAAKNQPPPHAACTLPHCSTMKEVLTHMTSCNVGRLCHSDTTQTTKKCSVAHCASSRQIIAHWKNCSREDCPVCKPLKRIQDTPLQFSLPDLANLIGVNGNSNGSAEGDGLHQFGSPAMRTGNITNSLFEGFNGNPFQNGPNRGGPRPPGGNGEIPNLPPPDMPDCTKEWHHQVTKDLRNHLVGKLVKAIFPEPNQEAMNDNRLKDLIAYARKVEKEMFESANDREEYYHLLAEKIYKIQKELQEKKNSRLNQGAAAHDQYAIPPSNELAQMLGVEGGRSDVHSEGSSMAVAPSQQNQPWGGAPNSNMHQQIPPNGQVPQVNNSSTFPSSGNSTPNIGASSTVSAMLQPKTEPMDDQNTDSLSSRPPTAIGFGGSSSSTPAPIMNGIVKKEEDPEESSNQAPPSVKDTKDGVAESKPKEQQAKREPTPPPTEDTVFSQEDLIKFLLPVWEKLDKSEDAAPFRVPVDAKLLNIPDYHEIIKRPMDLETVHKKLYAGQYQNAGQFCDDIWLMLDNAWLYNRKNSKVYKYGLKLSEMFVSEMDPVMKSMGYCCAKKLAFTPLSLFCYGAAMCTIAREQQYWVFEQSSTQYNVTVTERYTYCQKCFDALPPEGISLSENPNDRNNMAPKTSFTEQKNSVIDYEPFERCKYCMRKWHRICALHDKKVYPEGFICECCRTAKKYQKPDNKYLASKLPHNKLSTFLEDRVNGFIKKQLQAEAHKYPVIIRTLCVQDKEAEVKAQMKQKYVESNQFPEKFPYRTKAVFAFEIIDGVEVCFFGLHVQEYGSACPAPNARRVYIAYLDSVHFFQPRELRTDVYHELLLGYLDYAKMLGYTMAHIWACPPSEGDDYIFHCHPPEQKIPKPKRLQDWYKKMLEKGVQEGSVVEFKDIYKQARDDNLTTPTQLPYFEGDFWPNVIEDCIREASNEEAQRKVKEDDDDGEDADGGLGGGDSGKKKSSKNKKNNLKKNAKMNKKKAGSITGNEVADKLYSQFEKHKEVFFTIRLVSLQNEPAVLAKPISDPDGLMQSDMMDGRDTFLTKAREEHWEFSSLRRAKYSTLCLAYSLHETDSKGMEYTCNKCSSPAVWHCQSCDDFDLCDGCKPTTQHPHEMEKIKSLIGGGEAGDSAAGGTRYESIQRCIASLVHACQCRDANCRRMSCHKMKRVVQHTKMCKKRINGTCPVCKQLIALCCYHAKHCTRDACTVPFCMNIRQKLAEQKRSQQRRADMMMRRRMEGLQSHVGGAAPTPSTVSNGTPSNAPTPPVSAGPGPAVKGGGVGQVQMQQHQGSHVGGSGPAGMGQPMNSFGGMPGMGLGPNAQNGPGLPGMNPQMNANQSRYMPNGPGLGQSGAPGQQQQPMYSSGMPMQRPGGLGGMNPQQQPQQQQGHPGLQNPGGRPGGVHGMGQNQPVRNNQDMVMNMQMQNQHQQPPPFDSTLQPQIMKINSRLKAAKTEEERETVFSDLKKTPHLFHAWLRMRENQNLVPNRMQGYSQMSMGSSNLQNLQQQQLQQQQAGAMRGGGGFAPGQNNSQPRAPSGQFASMNPSMQQQYPQQQQGWPQQRQQNPGGMQQNANPYNQFQNRQNMMMMPQQQQPHPSNAGGQ
The following text describes a protein:
Function:
Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.
Sequence:
MYRSITAARLCLPSVNRAYIRFFTQHVRIPLTKPTTCSSLNLGLSNPTAIPTWSLHSTHRCYASKKSSKKQSVKNNGSDVEADTQDIDSSSEPAFQMDKYEQLMQNAVEKLRKDLGLIRMGRANPALLDSVRVKHQGKSVALVDVAQITVKDAHTLVIVVSDEQLVSVVEKAVRDANLGLNPQSLPPSSLKVPVPRMAKEFRETIIKNIGRIAEACRVRIRSARADARTALKRTSLKPNSDQSRMLEKDIQQLTDKYIKDTDAAVLAKEKEIV
The following text describes a protein:
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Sequence:
MSATPGGRTGAAATPSNAVSLKSIEVPQALQNGEKFIKWDEDSGVGTPVTLRVDKYGFYLHWVDQNHEMDLLDIATIRDTRTGRYAKIPKDPKLRQIVTMGSQDTLEEKTVTVCCANDFVNMNFINFCCTRKEIARLWTDALMSLAYNLNQINGTANLYLLKAYTKLILVTDKTGKIPIKNIIKMFAQSRDDKRRIETVLQSTGLPYGKNDTLSPEKFQFEDFFNFYKNLTQRSEIEKVFNDIVGSKKHMTAAQFVDFLNKTQRDPRLNEILHPYANTARAKDIIAQYEPNKYNAQKGQLSFDGFLRYLMSEDNNIIAPSKYELCDEMDHPLAHYFINSSHNTYLTGHQLTGKSSTEMYRQCLLAGCRCVELDFWNGREEPIIVHGYTFVPEISAREVLEAIAESAFKTSDFPVVLSFENHCNPRQQAKIANYCREIFGEMLLEAPLEAYKLEPGQPLPPPSVLKRKIIIKNKKKHHHHHHHHHHHKKSTSAQPEAPPSEPTGNGDVPHHAPPLQANCRQGSKDSTGTEDEESSSDEDGETLETDNSTEPTNEGSDHKAATAGETEAGAEISALVNYVQPVHFTSFENAKKKNRSYEMSSFDEKQATSLLKEYPVQFVNYNKHQLSRVYPAGTRFDSSNFMPQVFWNAGCQLVALNFQTLDLAMQLNLGIFEYNFRCGYLLKPEFMRRTDRRFYPFAESTVDGIIAGTVKITVISGQFLTDKRVGTYVEVEMYGLPADTVRKRFRTKTVPNNGINPVYDEEPFVFKKVVLPDLASIRIAAYEESGRFIGHRVLPVVGLCPGYRHVNLRTEIGQPLPLATLFLHIVVKDYVPDGLSDFAEALANPIKYQSDLEKRAQQLAVLTDDMEPAEGTEDQKKNSLSAKEQATNGSPIQRPLIATGAASVDATSDNEGPVIATSVDTKNPQHDSNSLPKNIEVKEEKFEELIAEPLDKILDNKLVKEKKLELDKKLENLRKKHEKKKMTLQSQKSGDFSEKRSRLINMKLVKRLSSKNIVSGVFSTESPSVEPLTCVADGPETSSGDPDKPSLPRSHSERLLSVNRDFVCQEKELREKYHEVIYNTAEKVMKISQNNQLKTLKDQFERETTDLMRKLQADHREEVKALAKKHRNREQFTRVKREAESAVVGRGVSEREKLGQIFESRREELQRQHEAVKDALAECRNKAKVALLKEFETRMARVESESGGVL
The following text describes a protein:
Function:
Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Important for endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKSICCVLVLCLLLCRRSTASESICELKDVSGNSNDWIVLREKPLGCWTDFQTENGTEVHIINLEDNPSVFTVNLLKANKSVVIFTSSSAQSSHAMLFDNPAVSIYVTNKTSLTFIHPTQKPLQILTAPPAGNVSAVLRWAAETFGGVTSVTNARNPKTITFTGVKGSQNSSRCELMPETPTEKPFIHLELNEPIEALKSCYMKHEGEKLHIINIPDGVTIRHVSVHLLSDCNVVLRGPAGTHWIIKNSLRIGILSNNQIHLQSFPLRPRMAISDNPTDIRQKALSYFSSGFISSYSEIRLNVTNVELWITDYSISSAPTEVEKTTPSPTSPPFPVQMQLFSSPDFTTPIDNNSRVLSDKRVYAEISSQTFREASIRVSSCWVRSTPVTREMPFREEPCFIKDCPKRLSFSFQILQDLPAGSWDLECAVKLCGVKRINNEESCTSETPVKRNVQVKPFTPTTNSCFEFGLSAVLGIAFGGFLIGVLLTGALWFIKIRTGHPVALGMRSTAAELSVLSISGCPCGLTKRQPVPTHPSPSENSSANASIGSTQSTPTSSMA
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Miscellaneous:
MISCELLANEOUS: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
Subcellular Localization:
Cytoplasm.
Sequence:
MVVIGEKFPEVEVKTTHGVIKLPDYFAEQGKWFVLFSHPADFTPVCTTEFYAMQKRVDQFRELGVEPIGLSVDQVFSHIKWMEWIKENLGEEITFPVIADDRGELADKLGMIPSGATITARAVFIVDDKGIIRAIVYYPAEVGRDWDEILRLVKALKVSDEKGVALPHKWPNNELIGDKAIVPPASTVDEVKQREEAKAKGEIECYDWWFCYKKLE
The following text describes a protein:
Function:
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MVRLKKSFGQHLLVSEGVLKKIAEELNIEEGNTVVEVGGGTGNLTKVLLQHPLKKLYVIELDREMVENLKSIGDERLEVINEDASKFPFCSLGKELKVVGNLPYNVASLIIENTVYNKDCVPLAVFMVQKEVAEKLQGKKDTGWLSVFVRTFYDVNYVMTVPPRFFVPPPKVQSAVIKLVKNEKFPVKDLKNYKKFLTKIFQNRRKVLRKKIPEELLKEAGINPDARVEQLSLEDFFKLYRLIEDSGE
The following text describes a protein:
Function:
Carboxypeptidase.
Miscellaneous:
MISCELLANEOUS: Since D.discoideum amoebae do not have a peptidoglycan cell wall, the function is not known.
Sequence:
MKNYKIITLLLIISILFNIIRSNKISLKDSDSGSNGNQDIQILINDILNNCSSSESSSCFGTQWGVVADIYTPSNGEFTNIFSLNELQAFTPASNTKLFTTISIFYTFGEDFKVFTPFFTDKPFNSVSGGSSNSELDFICVKGMGDPSMSIDNLIEAAKFFSSNPTMKKVNKLLLDTSFYNIGNGVDGNIPSAWEWEDLTSTYGSIPTPLIINENTMDIYITPSNVIGGKPTASFKYSGEDKYLPVIILATTTTTSNSSTSTLNYSFKMSSQSIYITGNCDINGGIQIITVPILDPEQYFLTVFSALLEDGGVEISQTAIGSCNYTGMDYKSFEVISPELSEMLNYTLLTSNNLYAETFLRQMGTFNSAASESTPTYQAGLEYIQQTLSIPTSLYTQVDGSGLSRNNFITPKSLITVIENVYTNVGDPQHDYISYLPVASLSGTLSKRFINTPASGIVHAKTGSMTGVNSLTGVILPNGLSDDQQNSIFFSIIANNSPAQNTDIIDIIDQIVILLTKFILSS
The following text describes a protein:
Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Releases lysophospholipids (LPLs) and free fatty acids (FFAs) from membrane phospholipids in response to hormones and other external stimuli. Plays a role in pollen development and germination and tube growth.
Miscellaneous:
MISCELLANEOUS: The enzyme has a slight preference for phosphatidylethanolamine over phosphatidylcholine.
Subcellular Localization:
Secreted. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum.
Sequence:
MITGLALSRVAFGLTAFLLLAVVSSQEKCSNTCIAQNCNSLGIRYGKYCGIGYFGCPGEPPCDDLDACCMTHDNCVDLKGMTYVNCHKQFKRCVNKLSKSIKHSNGEKIGFSTQCPYSIVIPTVFNGMDYGIFFSGIGNIFNPPVLGSVPVVEVDLARSKVDTKDGLGTKLGLQTKEGSKVSASLNI
The following text describes a protein:
Function:
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Subcellular Localization:
Cytoplasm.
Sequence:
MSPRALTFVSGNKGKIAEVAAVLGGLYEVRNVDIDLDEFQGEIDDIARRKCEAASEKVDGFVMVEDTSLCFDALGGLPGPYIKWFLKKLGPSGLHQMLSAYDDKGAEAVCAMAFTHGRGLPITVIKGVCKGRIVSPRGPNTFGWDPCFEPLDTGKTFAEMTIEEKNVISHRSKALAALRETLEKN
The following text describes a protein:
Function:
Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity. Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes. Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MNQRRSESRPGNHRLQAYAEPGKGDSGGAGPLSGSARRGRGGGGAIRVRRPCWSGGAGRGGGPAWAVRLPTVTAGWTWPALRTLSSLRAGPSEPHSPGRRPPRAGRPLCQADPQPGKAARRSLEPDPAQTGPRPARAAGMSEARKGPDEAEESQYDSGIESLRSLRSLPESTSAPASGPSDGSPQPCTHPPGPVKEPQEKEDADGERADSTYGSSSLTYTLSLLGGPEAEDPAPRLPLPHVGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEESLVLLPFDDLKISGKLLLCTD
The following text describes a protein:
Function:
Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
Sequence:
MASEDKFESVLSTRYCKNSPLVSILSETNKATLWRQLWIWLAEAEKELGLKQVTQDAIDEMKSNRDVFDWPFIRSEERKLKHDVMAHNHAFGKLCPTAAGIIHLGATSCFVQDNADLIAYRDSIDHILKRFATVIDRLAAFSLKNKEVVTVGRTHYQTASLVTVGKRGVLWAQELLMAFQSLSEFRDKMRFRGIKGATGTQDSFLTLFAGDESKVEALDELVTKKANFSNRFLITGQTYSRQQDSQLVFSLSLLGAAAKKVCTDIRVLQAFGELLEPFEKDQIGSSAMPYKKNPMKSERCCALSRKLINAPQEALTILADQGLERTLDDSAGRRMLIPDVLLTAEALLTTLQNIFEGLSVQTDNVKKIVEDEIAFLGLEKAMMMLTEEGVDRQQAHAVIRKTALEAKQLQATQKVDIRQTMADPFFDSVRDRVVGLVNNPINFTGRCVSQTESFIAKELKPTIDKYLDKSAGNVQLDV
The following text describes a protein:
Function:
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.
Sequence:
MPTGGHSVVPCTTVVTTSDHFIPFLCITNYTFKTISYINSYNTSSVISVRTVQQEILQSDIQSKADKSPVTVADYGSQVLVSLALNMEVTSGSFSMVAEEDSEDLRKDNAEEILEHITDLVNETLAENGSYNITLSKEGILSAIDTGKSEGGPSGRHWVLDPIDGTKGFLRGGQYAIALALLDEGKVVLGVLGCPNLPLTSISNLNGSSSGDQTGALFSATIGCGAEVESLEGSPPQKISVCTIDNPVNASFFESYEGAHTMHDLTGSIAEKLGVQAPPVRIDSQAKYGALACGVGAIYLRFPHKGYKEKIWDHAAGAIVVTEAGGVVTDASGNDLDFSKGRFLDVDTGIIATNKQLMPSLLKSVQEAIKEKSQAPSPL
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MKPVDWKIKTNFPAKFTSKYEDIEKLIQPMEHPSSKLQSVLPLHKIFYSKVSFNDKNNQDIFPTSHILMKLSKSKTASRDLVRHIFKDQNMENENEKKRARETDGGIQGPVSKKRCVIDGTDAATLKTELATEFDGSKLKQTDAIPMVKQANQKVPAKNDSSPAKSIFSSSFAQVFSMAHTIKLENPSHECGASQPFIESVSDSKPTQKLKAKRKQKPNLPRRLRKCIPLCYNILKKTDNRKLFSCLSYYTKFISPFERSFAKKNLNLLMELSTKELTEHISKMLQHYTPTHQVFLFLRSAIKKTFPIHLIWGTKHNRSVFLKNLERFLSCRRFDKVTVADFTRGMVVGDLPWLMGNDTSYNLLRFFQWMIEEYIFVVLSGSFYITENSNFKNRLFFYHKKMWAEIVAYGVALLLKQNRWAVPPIADDTKRPYFSVRFCPKVNGLRPIMRLRNADKMADMVPFEVIASVLKLVCSKVPQATGFATQHRAHIYNGWKQFVLSLAGIPGRKKLFFVKMDIHRCFDSIPVVKLIQIVESLLDRSGEVDLTSATKGKLNCKVKHCTHCILTTLKYFLNKVTLSVLSKKFVKLHGIPQGWELSNLLCDIFYGHMEQQHLINALGPIDNEPHLILRYVDDYLFVTTSRDKAIAFLKLMHSDDFKEYGFIVNTKKTCTNFASYCSQQLEDLQEQDTFPWFGYLFPACLNMGRKQLKQTGTHNFGGVSVDLSAYQSTKRIRDFISVQSPGTYNYFQQIRRNLTRRVTEICFDPQINGKMRIYRNLYELAMLGSIQMVAHQVHEGQPWLIGNPWHFRSNIKQVANAVLARIQRVFKSKHFLTRPLVRWLFYKAFKTKMKQHSNHKAALPVLQTGINQCVHQLCEVGEWDNVRPYLQRAVGMFPVHYRKVNCGS