lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a receptor for citrate and mediates taxis away from phenol. Also mediates an attractant response to metal-citrate complexes.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKNIKVITGVIATLGIFSALLLVTGILFYSAVSSDRLNFQNASALSYQQQELGGSFQTLIETRVTINRVAIRMLKNQRDPASLDAMNTLLTNAGASLNEAEKHFNNYVNSEAIAGKDPALDAQAEASFKQMYDVLQQSIHYLKADNYAAYGNLDAQKAQDDMEQVYDQWLSQNAQLIKLASDQNQSSFTQMQWTLGIILLIVLIVLAFIWLGLQRVLLRPLQRIMAHIQTIADGDLTHEIEAEGRSEMGQLAAGLKTMQQSLIRTVSAVRDNADSIYTGAGEISAGSSDLSSRTEQQASALEETAASMEQLTATVRQNTDNARQATGLAKTASETARKGGRVVDNVVSTMNDIAESSEKIVDITSVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRTLASRSAQAAKEIKVLIENSVSRIDTGSTQVREAGETMKEIVNAVTRVTDIMGEIASASDEQSKGIEQVAQAVSEMDSVTQQNASLVEESAAAAAALEDQANELRQAVAAFRIQKQPRREASPTTLSKGLTPQPAAEQANWESF
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNKKSILKKPKNAQSTQEKQLITWSKSLIDEARSRLQYDFFALEWIEKLVDPVSLETLEEARKYLRKSDYDQVVKERKLVNLCGYPVCPYEPKQQTRYKLEDSGMKVYGGLNYYCSKDCFLKSCQYMVELSDEPLWIREDAREAMKQHLDPRQDEAFRKELENKKIEDVRLLLQALPVGYKAKVGEIVEHPLANEQS
The following text describes a protein:
Function:
Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.
Sequence:
MAASVEYNRQVSAHPWPTNAQPKAAFDLFSSSGGGRRRSGADSDSDDEDSVPPDWRSLYSPRLDVEPSVKDPRDEATSDAWVKRHPALVRLTGKHPFNSEPPLPRLMSHGFITPVPLHYVRNHGAVPKADWSTWTVEVTGLVKRPVKFTMEELVTGFQAVEFPVTLVCAGNRRKEQNMVRQSSGFNWGPGAISTTVWRGVRLRDVLRRCGVMGAGAASNVCFEGAEDLPGGGGCKYGTSLRRSVAMDPARDVILAYMQNGEPLAPDHGFPVRVIVPGFIGGRMVKWLKRIVVACNESESYYHYRDNRVLPSHVDAELANAEAWWYKPECMINELNINSVITTPGHDEVLPINALTTQKPYTMKGYAYSGGGRKVTRVEVTLDGGETWQVCDLEHPERPTKYGKYWCWCFWSVEVEVLELLGAKEMAVRAWDEALNTQPERLIWNLMGMMNNCWFRVKINVCRPHKGEIGLVFDHPTQPGNQSGGWMARQKHIETSETTQGTLKRSTSTPFMSTASAQFTMSEVRRHASKDSAWIVVHGHVYDCTAFLKDHPGGADSILINAGSDCTEEFDAIHSAKARGLLEMYRVGELIVTGNDYSPQSSNADLAAIVEAPAVVVPRLPASAVALANPREKVRCRLVDKKSMSHNVRLFRFALPSPDQKLGLPVGKHVYVCASTGGKLCMRAYTPTSSVEEVGHVELLIKIYFKDEDPKFPAGGLMSQYLDALPLGAPVDIKGPVGHIEYAGRGAFTVGGERRFARRLAMVAGGTGITPVYQVIQAVLRDQPDDTTEMHLVYANRTEDDMLLREEIDRWAAANPARLKVWYVVSKVGRPEDAWEYGVGRVDEQVLREHLPLGGDGETLALVCGPPAMLECTVRPGLEKMGYDLDKDCLVF
The following text describes a protein:
Function:
Plays an important role in the degradation of dermatan and keratan sulfates.
Sequence:
MHATGILYPRPSESRETLSLDGIWKFAIANRSEQNKGFEEKWYQAALQHVTIMTSPKTRILGITLDELGITEIFLFGSVNYFAIWINGVEVTSHSGGYLPFDVEVTDHLKFGHPNFITVAVNSKIVYHNDSQRYPAGYYEQQYNFAFFNYAGIHRPVIFSATPKTYIDDITINTTSVSDSEGTVSYSVELGGSKIAAYSVIAKVYDSRDRLVAQSKGLTGEIRVTNPNLWWPRGMNESVGYLYTLKVLTYKYLLPFGIRFIHWNSTGVYLNGKSVYFKGFGQHEDASLRGRGLDLVTLTKDYNLMRWIEANSFRTSHYPYSEELMDLADQQGFLVIDEVPAVGLDNFDDDLLEAHKQALKELIQRDKNRPAVVMWSIGNEQQSQKQVSAHYFERVSNYTRSLDLARPVTMAQFLDVICINRYFGWYSDTGHSELITYQMIKEVTAWHDKHLKPVLVTEYGAGALAGLHTDPPVVWTEDYQVVLMEQNFKAFDQLREMGFLIGEIIWNFADFATPQEYFRPTGCMKGVFTRDRQPKFAAHFLRRRYAQLFC
The following text describes a protein:
Function:
Involved in the regulation of gamete interactions during the double fertilization and to prevent multiple-pollen tube attraction; mediates the redistribution of the gamete fusogen HAP2/GCS1 to the cell surface after secretion upon sperm arrival.
Subcellular Localization:
Cytoplasmic vesicle. Secreted.
Sequence:
MALKNVCLVLVVTLCLLAYASTATRTSYDHKVNTPGYDLAARLQAYQGQFMECWNSLQALSSCSSLTVQFFLTGKADIASCCGSIDIIWSKCSWPSAVISLGYTPAEANILKTYCDAVSAPPANRKP
The following text describes a protein:
Function:
Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
Sequence:
MKASGSIKVFTGILVFILIWLVVTQILEMKLLGSIFDTLMNVGVIALIVLFQDEIRRFLLTLGSHRHVSALAHFFSGARKEALKHDDIMPVVMACLSMGKQKVGALIVIEHTTPLDEVVRTGEIIDAAISQRLIENIFFKNSPLHDGAMVISKKRIKAAGCILPVSHDLNIPKELGLRHRAAMGISQKSDAHAIIVSEETGAISVAYRGQFYLRLNAEELESLLTKEN
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MSSKTASTNSIAQARRTVQQLRLEASIERIKVSKASADLMSYCEEHARSDPLLMGIPTSENPFKDKKTCIIL
The following text describes a protein:
Function:
Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions.
Subcellular Localization:
Nucleus.
Domain:
The homeobox DNA-binding domain is necessary for its nuclear localization, transcriptional and erythroid differentiation activities.
Sequence:
KLMKQGGAALEGSALANGRALSAGSPPVPPGWNRIPPLGRAQEE
The following text describes a protein:
Function:
Genetic data indicate it may be involved in ribosome assembly or function.
Sequence:
MIIFSNLSLKRGQTELLENASATINPKQKVGLVGKNGCGKSSLFALLKKELMPEGGEVNYPANWRVSWVNQETPALDISAIDYVIQGDREYCRLQQKLERANERNDGNAIARIHGQLETLDAWTIQSRAASLLHGLGFSQEETIQPVKAFSGGWRMRLNLAQALLCPSDLLLLDEPTNHLDLDAVIWLERWLVQYQGTLVLISHDRDFLDPIVTKILHIENQKLNEYTGDYSSFEVQRATKLAQQTAMYRQQQQKISHLQKYIDRFKAKATKAKQAQSRMKALERMELIAPAYVDNPFTFEFRPPQSLPNPLVMIEQASAGYGIGESAVEILSKIKLNLVPGSRIGLLGKNGAGKSTLIKLLAGELTALSGTVQLAKGVQLGYFAQHQLDTLRADESALWHMQKLAPEQTEQQVRDYLGSFAFHGDKVNQAVKSFSGGEKARLVLALIVWQRPNLLLLDEPTNHLDLDMRQALTEALVDYEGSLVVVSHDRHLLRNTVEEFYLVHDKKVEEFKGDLEDYQKWLSEQNSTSENKVSEKVGDNENSVQNRKEQKRREAELRQQTAPLRKKITQLEEKMNKFSSELANIENQLADTELYNAENKEKLTALLAQQVDVKKALDDVETEWMTAQEELEEMLQA
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MESFKQNAKFNDIEPMDNKRMLVLSLGTGIASMDAPKYDAVTANNWGMLDGIFLNGNTPLLDACGQASSDVVDFRVSALFRTSRCKENYLRIQDDWLTGAASTADIATEENLQKLVGIGNELLKKPVSKLNFETGRLEEDEGLTNEEALAKFAIGLHEQRCFRLSA
The following text describes a protein:
Function:
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Sequence:
MKLAPFLIPFIATTVTASLAGEALSWAGQLVGGGRGALATGDGPVRTENSWSYVDCGLATDAIQLKSIKVHPDPPVPGKNLTVTVEGDVLETIEEGAYVDVTVKLGLIKLLQKEFDVCDEARHANASVQCPVQPGPYTVTETVELPQEIPKAKFSVLVRGYTVDDEDMVCLDLFVDFMKK
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MADEPLATWFTLTHQRNVLHLDFRGVITASAFLTVQPTNPSLQAIYLHASPHLHIHSVFLSSPTPSEPLLATPASFALSNPYQPLPVREPPIDIKSHPEIKRKTWAAMGESDEGELAISVSGGWVRLVESQNIAGREPQVTFAPIQVRIDYQLVVGGDVIEGIVFRRPGDGGNEYQIPHMFLSPTTYNSARVWTPCIDSLFERCTWELEFVVPRYLEGGEPLDGEEGYPVMVVSSGELMEQITHPHDPHKVIFYYLQTNPTSVQHISFAAGPFQMHCISADESHKPILGFCLPGDLDLLANSTSFLPRVMAFTTELGSYPFTDFKVVFVSNPRSECSTSATLAIASSDLLHPPSVIEQAISVRQTLSLALIQQWIGINIIQRNYSDTWIVNGLALYILGQFIRHLLGNNEYRFRLKKDIDRCVMQDQGAQWPLCVPGQVDPPDSATTAFINIKAPLVLHILDRHLAKAGTSLGLSQVIPRILMAALSDDLPGNTLTTSYFLRQCRKVSGLDLQTFQDQWIFGSGCPRLSVRTNFIKKKFTVEFMVSQTQPAVEAINEMSEKQRKVAVWRRPTPFFEGSLTVRIHEADGAPFEHLIDIKTPQKTFPLPFNTKYKRTRRSGHIAARFNKMQDALDAANEPSNDDEEEAKLEAADRAGVFAYPPWDDEEERRRWKVAEWGEGEANAMLGEGGGYEWIRVDPDCEWLAIFEFAEKPWCWISQLQGDRDVIAQLEAIQNMRMYPSPVIASELARTVLVKNYFYRVRMEAARALAMYNSSECDYIGYFLIMKLFQAFYCQPSSGNETEPPEIQCRPLPNDFSNFADYFVKKSLIAAMADLRDPATRAVWRHVRITLLDLLRLNDNTSNQYSDSFYLAAVITAISNAFTVGSAAQGMLSETEIESEQLLQKEATDVLDRAMTVDRLVPSYHNVVTKAGLEAQMKSILAGQRTNDSRELLSYTREGNFEAIRMVAFDGLLLCKPPGRSPAVDKYLLDVIANDQSLTIRRFVARNLSESILVSLALGEITGALPLPGVVDVTNETDQMREQRTEGQNNAIVKALRKDFGAKLEVKRLVQDSLIESFTMPDPEVRFALLKVAEIIASSTSEPQPGNLITLSTPTVETPTAPQPPKIRISMPSAEIVSDSQGYGFPAPENPVVTPRTAAKIVLNPNAPTPSTHKKKDAPKAQRKGLSDNDFKAIAIALNKLVADKRSFFFRQPVDPVRDNAPDYLTVIKKPMDLSTIRAKLDNGMYTNRQDFVSDIRLIIANCYTYNAAPTSPVRKAGEAFEKLFNTLWAKTENTLSAQRSSHATTPSKAMPPPPLPQAEPTASTSVKVKVKPPKSVTIDPAPAPVMPPPPLPIAKKASMARPPATEEKKEKQAKKRKEPGETSKSNLDDLLGAEVDAMGSEAATNDPLTDLLEEPKQPTKKSKLPVSSKISKSTTSKESSAAPSSSNEKPSVKKAKIKVQSGGSSSPVPRPPVPAEQPSVSQTLVPSPIAPSTVISAQPQPPSDLPPTKSNSMSFKAKRAKALLTTLQKEPSAILFLRPVDPILDGCPTYLDEIKHPMDLGTIGKKIDQKKYKTMGQFARDIELVFANCRQFNPPGEITALADKVEEVYWRDWPKTVSSKMTGDEKKSMVSMLNQALKNPLSEWFRLAVDPVALGIPQYFDIIPPEDARDLGLIKLKLEKGQYQTAKQVDEDVELMLENARVFNGEGPVVDAANALGKWWQSQRSKMDV
The following text describes a protein:
Function:
This is a membrane-bound, calmodulin-sensitive adenylyl cyclase. Inactivation of this cyclase leads to a learning and memory defect.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDHAVKATRGRPLNTLRFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNIFNAIVCGLFAVVLVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRKPLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAASALGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFRKRHSVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLLILGAALQVTALPRTLILLLLFLFAFIWVSAILMLLLAVRLKWIIWDISESFSLRMAITIFTVILIYSVGQVNVFTCVSDHPCSGNGTTSFQNDSHRKCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNRVNASIPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFLCDSGNKSLNGEVRNAMSLPQSLHAPDYYMKVSQFPENRVNTDTYSKKENGHLYAGNGVEEQQLLLQHQHKQHDPLPLPAPPPPVHHHLHQQQQQRLNSKLQKQPIFMANGGLPNIRENGNGHNGEHQQQQQQQQQHQQQQQQQQQHGGFMVATTTPPAAVAVPLQPQHHQLQFQHPHQHPLPSAVSVPVQHQILLHHQLQLQHQPVPSVMLREFNIIENPTSGGRHQQMEQLPPHHGSLDLSGMGMGVGAGVLGSDCFMMPRRDRERTYVPPLNQHGHHPPHHLHSNLNLNQSQHPPSFTSLGYGQCRESEPLLHASSVAPVAKIMPMQHAPKYEPPRYTSPHTMLSQQHQQQQQQQHQHQQPQSQSAQDQQTHPAQDPHPLQRQYAMYSQQPQLPPKPVLRTYMKPLPKLPTDLEESRDMSSTDDLSSRPHSPSMSSSDESYSKTTEGEGEGDEDSPRMVNGGHLHHRNGYHLPAGGLVNPLQWLYPCDIQVDPTSPVVDMAHLHDFELSSTTESQGHHTNSNTTSNTQHKGDSCNSFDFQKAAVGTAAGAAIATKSPFERELQRLLNESSRARCLATATTTAGAISTTDQTASNGSRELSYSLSNGKLSSANGHGVGGSGSGSGSGSGSGSAVGNGSGGSGSSNGNLSGGSGSNSNSGNNNSSHHKTEQQQNMDHEHLAGGKLLGSNSFMIAKHPVGLEAIKEITRNKNPSESSQMQTSDTESCEILHENRNQMHVLAMLEMHTAKELNGSHAHHGQHHQQPQRTHRQRPRSKELQYSHESLDGLDGAVQSQSQQRHQRYHHHHHHQQRQQQQQRYNHVQEQEERDDTEDNLADEEFEDDEVGRDVRQKRLQKSELNHKRSEVATEAGNHHDDEVEEEDDDDDEEEDHRNGGREAAPLTNGSMRGLEANVINDELKYGATHLNHQSMDSNPLESQSEWSDDDCREEATGGAESTGYITDEPGLENISLLNEAGLTDAEGALSDVNSLYNAPDVDDTSVSSRASSRLLSLDSLSGLYDCDLDSKHELAIVNASHKISSKFGQPLSPAQQQHQQQQQQQQQQQQQHHQQQLQQNPQHTQAQSHLAPVQFQSAEELRE
The following text describes a protein:
Function:
Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. HybF is involved in maturation of hydrogenases 1 and 2. It may partially substitute for the function of HypA and vice versa.
Sequence:
MHELSLCQSAVEIIQRQAEQHDVKRVTAVWLEIGALSCVEESAVRFSFEIVCHGTVAQGCDLHIVYKPAQAWCWDCSQVVEIHQHDAQCPLCHGERLRVDTGDSLIVKSIEVE
The following text describes a protein:
Function:
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
Sequence:
MSNFVGRMNQQTGQLEWVKQEDDHDYYLEISRSLYGDMLHDKERNVQYDQAIQKAVQAYLDVNPSSSSCNVLDIGTGTGLLALMAARAGAKKIYACEAFQPMAQLAQKIITENRYQDNIKIIQKRSTSMTADDDMDGCKADLIVMEIFDSELIGEGVLGTMLHAQQNLVKPNCVSVPAAAKIYVQACESKFLQKCCNLNPVKSQMSVRRVEGKDNEFTISGRRTLELTAIEDGVCHGLLFWWVLKMDCEGNIELSTAPKWIDNKSNHNLQWRDHWMQAVYFCPQSISVTKGKSISIDVSHDEYNIWFNVSSSSPRTNATSDVDKYSHQLCWDKMRLSGLNNVEKQRKYYNVIRKHIQNSFNVHCVSVGDGSLLPLMAASAGARKLVRANGLNKKIMISPRNLADIGSDDLLGNKIDILLGEPYFGGSVFSWYTYWYARTSLENFMADKVAVIPAFAIIRAIAVELDHNWLLRSPISDVEGFTMGGYNDLLDIVKSRLPNTDCNHEIEAIPLWEYPCRALTDKFDLLRFDFSKPLPMNTVVNSGKLQFKRSGICHAIVIWLDYFLDEEEVVSTGLNQVSDDDHGTIEWCKDYKQGIIILSQPENIQNSADDRDIYFNAIFNPDEANVHFKFKLKHAEIITNWEN
The following text describes a protein:
Function:
Inhibits host platelet aggregation induced by low concentrations of collagen via blocking the von Willebrand Factor (VWF) interaction with collagen.
Miscellaneous:
MISCELLANEOUS: Does not interact with host vitronectin (VTN), fibronectin (FN1), fibrinogen, VWF, recombinant platelet receptors GPVI (GP6) and integrin alpha-2/beta-1 (ITGA2/ITGB1), thrombin (F2), and coagulation factors Va (F5) and Xa (F10). Has no effect on host blood clotting, vasodilation, inflammation and murine splenocyte proliferation. Reduces occlusive thrombus formation time in photochemically induced thrombosis model in mice without compromising hemostasis.
Subcellular Localization:
Secreted.
Sequence:
MKKFCLIFLLLALTALHVKGSPIPDEESEETEDAEQEEDAEEEEHAEEEAQEDGDQTQDTDQESDDGQEETANQGSDEQQEEDGSHGTDETDDEAAGSRTEDVESGGDEQNDGEENGSQENGEEVTGGEDDSHGAQDSEGGEEDAAAQEAGGKKSKGKGAKGGQGSNRAGSSSGGEESAAHTYQEVMRILNGIKINAKEPLKSRLVNGLQYLKVDTINRVENIQKFSRIEHCFGNLDHIVQLYAGDAVERNDYCKGTCIDMVSNEFRGQMEELTSRLYPCLQGGYY
The following text describes a protein:
Function:
Cyclin with roles in multiple processes including transcription, meiotic recombination repair, cell cycle regulation, and promotion of normal growth and metabolism. Binds to the promoter region of the homeobox gene Abd-B and is involved in maintaining Abd-B expression in the pupal epithelium. Involved in the transcriptional repression of the homeotic genes Scr and Ubx. Plays a role in meiotic recombination repair of DNA double-strand breaks which ensures efficient translation of grk and promotes grk activity in the oocyte, leading to oocyte dorso-ventral axis formation following secretion of grk from the oocyte and its binding to Egfr in the directly overlying follicle cells. Negatively regulates the binding of serine/threonine-protein kinase Akt1 to the protein phosphatase 2A subunit wdb, promoting normal growth and metabolism. Required for the formation of bilateral symmetry. Negatively regulates cell cycle progression by preventing G1 to S transition and retarding S-phase progression.
Subcellular Localization:
Chromosome. Note=Localizes mainly on active chromatin.
Sequence:
MSVPVRYSSAAAEYAAEVDCELESTLQQQQQLHLQQQYEQYQHYQYQREQDIAYYCQLQAARQQEQLMQQRTSMSSSVMPGLALPQDHQDHPAALLNGPHNNNIGLAMDAHSINAILVDDEQPSTSAQAAAAAAASAGGSAGAGSGSGLGGAIGGGKLANGINRNAEMPTDWMRIADEGRYGTPGAAGLEYQKYEQQQQLEDLAESEAGAVGGASNNNGESSSSLKKLEDQLHALTSDELYETLKEYDVLQDKFHTVLLLPKESRREVTAGGRDGSAYVLRCLKMWYELPSDVLFSAMSLVDRFLDRMAVKPKHMACMSVASFHLAIKQLDLKPIPAEDLVTISQCGCTAGDLERMAGVIANKLGVQMGHAPITSVSYLRIYYALFRNLAKEIGGDFFKFYQQLIKLEELENRLEILMCDVKTTVITPSTLALVLICLHLDFHIKESYTRGSPELKHVFEYILFLQQYMRIPDRVFTCGFSIVSGILSHYNGQNKAPYKQRLVWKLSSRTLRVLRPINRFSSDLPTIEEGIPNALDDGLRSRTESISSEEEEDWPTSPIIPIFEQC
The following text describes a protein:
Function:
Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process.
Sequence:
MSETFKPAPGDVELVQREECFRGFYRLDRLRLRHRQFDGSMGREISRELFVRHDAVCVLPYDPQRDCVVLIEQFRVGAMQKLANPWLLELVAGLIDKDEQPEEVAHREAMEEAGLTLGALWPITQYLPSPGGTDEVVHLFVGRCDSEGVGGVHGLPEEGEDIRVHVWPLEDALQAVRDGRINNAASIIALQWLALNRAEVRGLWA
The following text describes a protein:
Function:
Binds and inhibits CYCD2-1/CDKA-1 complex kinase activity. Regulates cell division which is crucial for plant growth, development and morphogenesis. May regulate early lateral root initiation by blocking the G1/S phase transition. Controls the mitosis-to-endocycle transition and the onset of the endoreduplication cycle during leaf development through inhibition of mitotic CDKA-1 kinase complexes. Specifically targets CDKA-1.
Miscellaneous:
MISCELLANEOUS: Treatment with auxin induces lateral root initiation. ICK2/KRP2 protein abundance is regulated post-transcriptionally through CDK phosphorylation and proteasomal degradation.
Subcellular Localization:
Nucleus, nucleoplasm. Note=Homogeneously distributed.
Sequence:
MAAVRRRERDVVEENGVTTTTVKRRKMEEEVDLVESRIILSPCVQATNRGGIVARNSAGASETSVVIVRRRDSPPVEEQCQIEEEDSSVSCCSTSEEKSKRRIEFVDLEENNGDDRETETSWIYDDLNKSEESMNMDSSSVAVEDVESRRRLRKSLHETVKEAELEDFFQVAEKDLRNKLLECSMKYNFDFEKDEPLGGGRYEWVKLNP
The following text describes a protein:
Function:
Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion. In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption. Acts as a receptor for PSG17. Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Secreted, extracellular exosome.
Sequence:
MPVKGGTKCIKYLLFGFNFVFWLAGIAVLAVGLWLRFDSQTKSIFEQDTQPSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYKDTYSKLKSKDEPQRDTLKAIHYALNCCGLVGGVEQFISDICPQKDVLSSITVKPCPEAIKEVFQNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRSREMV
The following text describes a protein:
Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNDDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGDMTLKSALALAVKVLNKTMDVSKLSAEKVEIATLTRENGKTKIRVLKQKEVEELIKLHEEEEAKIEREKKEKEQKEKDK
The following text describes a protein:
Function:
Involved in regulation of actin dynamics.
Subcellular Localization:
Cytoplasm.
Sequence:
MATEQIYKQFTSRTLLNFFEVAALTDGETNESVAAVCKIAAKDPAIVGVSVRPAFVRFIRQELVKSAPEVAGIKVCAAVNFPEGTGTPDTVSLEAVGALKDGADEIECLIDWRRMNENVADGESRIRLLVSEVKKVVGPKTLKVVLSGGELQGGDIISRAAVAALEGGADFLQTSSGLGATHATMFTVHLISIALREYMVRENERIRVEGINREGAAVRCIGIKIEVGDVHMAETADFLMQMIFENGPRSIVRDKFRVGGGFNLLKELRDCYESWDSVGVSPDTSP
The following text describes a protein:
Function:
Sodium export from cell, takes up external protons in exchange for internal sodium ions (Probable). Also capable of exporting potassium ions.
Miscellaneous:
MISCELLANEOUS: Present with 1480 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAIWEQLEVSKAHVAYACVGVFSSIFSLVSLYVKEKLYIGESTVAGIFGLIVGPVCLNWFNPLKWGNSDSITLEITRIVLCLQIFAVAVELPRKYMLKHWVSVTMLLLPVMTAGWLIIGLFVWILIPGLNFSASLLISACITATDPILAQSVVSGKFAQRVPGHLRNLLSAESGCNDGMAFPFLFLSMNLILHPGNGREIVKDWICVTILYECLFGCLLGCFIGYVGRITIRFAEKKNIIDRESFLAFYVVLAFMCAGFGSILGVDDLLVSFAAGATFAWDGWFSQKTQESNVSTVIDLLLNYAYFIYFGAIIPWSQFNNGEIGTNVWRLIILSIVVIFLRRIPAVMILRPLIPDIKSWREALFVGHFGPIGVGAIFAAILARGELESTFSDEPTPLNVVPSKEESKHWQLIACIWPITCFFIVTSIIVHGSSVAIITLGRHLNTITLTKTFTTHTTNGDNGKSSWMQRLPSLDKAGRSFSLHRMDTQMTLSGDEGEAEEGGGRKGLAGGEDEEGLNNDQIGSVATSGIPARPAGGMPRRRKLSRKEKRLNRRQKLRNKGREIFSSRSKNEMYDDDELNDLGRERLQKEKEARAATFALSTAVNTQRNEEIGMGGDEEEDEYTPEKEYSDNYNNTPSFESSERSSSLRGRTYVPRNRYDGEETESEIESEDEMENESERSMASSEERRIRKMKEEEMKPGTAYLDGNRMIIENKQGEILNQVDIEDRNEARDDEVSVDSTAHSSLTTTMTNLSSSSGGRLKRILTPTSLGKIHSLVDKGKDKNKNSKYHAFKIDNLLIIENEDGDVIKRYKINPHKSDDDKSKNRPRNDSVVSRALTAVGLKSKANSGVPPPVDEEKAIEGPSRKGPGMLKKRTLTPAPPRGVQDSLDLEDEPSSEEDLGDSYNMDDSEDYDDNAYESETEFERQRRLNALGEMTAPADQDDEELPPLPVEAQTGNDGPGTAEGKKKQKSAAVKSALSKTLGLNK
The following text describes a protein:
Function:
Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.
Subcellular Localization:
Secreted.
Sequence:
MKPLLLLTLLGCLAAALAVPAQKVKWCVKSDQEFRKCSDLAAASPAFSCVKKESTLDCIIAIKAGEADAITVDGGDVYTAGLNNYDLHPIIAEDYGTSSETCYYAVAVAKKGTTFGIRDLRGKKSCHTGLGKSAGWNIPIGTLVSMDIIQWAGVEDKPVEEEVSTFFQASCVPGATRGSKLCELCKGDCSRSQKEPYYDYNGAFNCLAEGAGDVAFVKHLTVPDQEKSKYELLCRDNTRAPIDDYKKCNLARVPAHAIVTRKDPQLAELIWTSLNSVQNFNLFSSEAYAPSKNLMFKDSTQRLVKLPQNTDSFLYLGAQYMSIVRSLKKEQTVGTNSNAIKWCAVGHAETAKCDTWSINSVTDDTAAIECQNAPSVEECLKKIMRKEADAMAVDGGEVYTAGKCGLVPAMVEQYDAELCSSSGGQASSYYAVAVVKKDSGVTWENLKGKKSCHTGIGRTAGWNIPMGRIYDQTKDCDFTKFFPSGCAPGAEASSSFCTLCKGSGKAVGDEAKCKARPEEQYYGYAGAFRCLAEGAGDVAFIKHTIVGENTDGNGPDWARSLKSDDYQLICPGKGPVPISEYASCNLAVVPAHAVVTRPESRSDVVRVLQVQQTFFGASGSDPSFKLFQSQNGNNLLFKDSTKCLQEVPAGTSYDQFLGSGYMEAMTSLRKCSDTASDLEKSCTFHSCQQT
The following text describes a protein:
Function:
NAD-dependent deacetylase, which plays an important role in the regulation of transcriptional repression.
Sequence:
MNKRSLENNELNEIQNNQNKNNNNKINKEIPSDNTPLKKLKSINSLEQLQEVDEDEDLDVEIDTKLINKLDKKGRKYEFVGEGYSDEEQISDDYEDDESSEYEYGYENEDELLDDEDHLDNINEIKKIQKKLVNTETSTSITNTSSTTTTSTSTTTTTTTKTQINETILLDILNNNKDEVDDEIQRIGNNVGNSKEEEGEEEEENIELVARSFIYKHIQEKKSLGIDPIEFTKDIGFKLELEKDDDAWEIITAFLTRKKVAVNLFLNYLKYNTLARPYRKKIATLDLSTFEKVCQLFESSKNIVIITGAGVSVSCGIPDFRSKGGVYETIEKKYNLPRPESLFDIHYLRANPLPFFEFAKEIFPGNHKPSPTHSFIKLLDEKGKLLRNYTQNIDTLEHVAGIDREKLVNCHGSFSTATCITCKLTVDGTTIRDTIMKMEIPLCQQCNDGQSFMKPDIVFFGENLPDRFDQCVLKDVKDIDLLIVMGSSLQVQPVSLLPDIVDKQIPQILINRELVAQPHEFDYVYLGDCDQFVQDLLNKVKW
The following text describes a protein:
Function:
May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.
Sequence:
MPLPCENILLRALRCISLWSSSSKPSSDANFRSLADLLSLSLQGLKPDDVTKAGLFADLDEHKVLSNPASSSQDRAMARLISHKALKAKLDTVRAKFSIVPDQKMVSHMKKTVKDKQPGHKAKKTADKTEQMKTGNRPAENTGKTQTQTDSTVENTEQMSDVIVGQTSSHGESSVSDVGEEGKIHQSTSETKTLTESPSTVEIDVSTRNSESESEDDEEDSEEEMEEDADSEMEEISSQMTESPTESKTESQVNLSESRETNDQLSTKRTEPSTAKRKGPRKAACDAEEDEDADEEDKEETTVTEGDDMFLREGDPDPEEDTDGRKTTPDSGGGLGVPAVARALPGESLFIGSLSGGRRGRHVKKGKFEKKMGKRPMERGTLQKFAARGKPQQHTRAPGAGKVTKPSSSDSPAHLHPSWAAKRKQKEQAGQIAAFQGKKIVFDD