lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
Sequence:
MIDVAIHPIEYRYGTAEMKYVWSQENRLAKILQTEAALALAEADMGLIPAEAAEIISECVPSVKAERVDEIEAEIHHDMMAVVVAISEKCREDAGKWVHFGATSNDILDTATALQIKDAIDLLEDKLKILLRVLVNQAEAHKNTVCCGRTHGQIGVPTTYGLRFAIWASEISRHLDRLYELTPRATVGQMTGAVGTQAAFGKSGILIQKLTMQHLGIGAVDVSNQIIQRDRHAEFVMWMANTVTTLDKIGIEIRNLQRSEIAEIEESFGKKQVGSSTMPHKRNPIKSEQICGLARIVRAMVEPELLNNTLWDERDLTNSSCERVVFPEACVLTDHILKLGIRVLENLRFYPENIRRNLDLLRGLNMGEAVMIELAKRGVGRQEAHELVRTSAMEAHETGQHFKQVLLDTPSVSRYLSVEDIEKLVNPDKYIGTAVEQVEALVVRLREAYSL
The following text describes a protein:
Function:
Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4.
Subcellular Localization:
Endosome membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
NGSKNLGKFISSPTKEKGNIQLSYSDGDDCGHGKKIRTNITLVCKPGDLESAPVLRTSGEGGCFYEFEWHTAAACVLSKTEGENCTVFDSQAGFSFDLSPLTKKNGAYKVETKKYDFYINVCGPVSVSPCQPDSGACQVAKSDEKTWNLGLSNAKLSYYDGMIQLNYRGGTPYNNERHTPRATLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECVVTDPSTLEQYDLSSLAKSEGGPGGNWYAMDNSGEHVTWRKYYINVCRPLNPVPGCNRYASACQMKYEKDQGSFTEVVSISNLGMAKTGPTIEDSGSLLLEYVNGSTCTTSDGRQTTYTTRIHLVCSRGRLNSHPIFSLNWECVVTFLWNTEAACPIQTATDTDQACSIKDPNSGFVFNLNPLNSSQGYVFFNIGKTFVFNVCGTMPVCGTIQGKPASGCEAETQTEDLQNLKPERAVGIEKSLQLSTEGFITLTYKGPVSAKGSADAFIIRFVCNDGVYPAISRFLHQDIDSGQGIRNTYFEIETALACVPSPVDCQVTDLAGNEYDLSGLSIVRKPWTAVDTSVDGRKRTFYLSVCSPLPDIPGCHGSAMGSCLVSEVNNWNLGVVQMSPQAAANGSLSIMYVNGDKCGNQRFSTRITFECAQISGSPTFQLQDGCEYVFIWRTVEACPIVRVEGDNCEVKDPRHGNLYDLKPLGLNDTIVSAGEYTYYFRVCGKLSSDVCPTSDKSRVVSSCQEKREPQGFHKVAGLLTQKLTYENGLLKMNFTGGDTCHKVYQRSTAIFFYCDRSTQQPVFLKETSDCSYLFEWRTQYACPPFDVTECSFKDGTGNSFDLSSLSRYSENWEAITATGDPEHYLINVCKSLAPHGGTEPCPPEAAACLLGSSKPVNLGRVRDGPQWRDGVIVLKYVDGDLCPDGIRKKSTTIRFTCNENQVNSRPMFISAVEDCEYTFAWPTATACPVQNNEHDDCQVTNPSTGHLFDLTSLSGRAGFTAAYSEKGLVYMSICGENENCPPGVGACFGQTRISVGKASKRLRYVDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEAGPTNRPMLISLDKQTCTLFFSWHTPLACEQATECSVRNGSSIVDLSPLIHRTGGYEAYDESEDDASDTNPDFYINICQPLNPMHGVPCPAGAAVCKVPIDGPPIDIGRVAGPPILNPVANEIYLNFESSTPCLADKHFNYTSLIAFHCKRGVSMGMPKLLRTSECDFVFEWETPVVCPDEVRTEGCALTDEQLLYSFNLSSLSTSTFKVTRDSRTYSVGVCTAAAGPEQGGCKDGGVCLLSGTKGASFGRLQSMKLDYRHQDEAVVLSYVNGDRCPPETDEGIPCVFPFTFNGKSYEECVIESRAKLWCSTTADYDRDHEWGFCRHSNSHRTSSIIFKCDEDEDIGRPQVFSEVRGCDVTFEWKTKVVCPPKKMECKFIQKHKTYDLRLLSSLTGSWSLVHDGVSYYINLCQRIYKGPLGCSERASICRRSTTGDVQVLGLVHTQKLDVIGDKVVVTYSRGYPCGGNKTASSVIELTCTKTVGRPAFKRFDIDSCTYYFSWDSRAACAVKPQEVQMVNGTITNPINGKSFSLGDIYFKLFRASGDMRTNGDNYLYEIQLSSITSSRNPACSGANICQVKPDDQHFSRKVGTSDKTKYYLQDGDLDVVFASSSKCGKDKTKSVSSTIFFHCDPLVEDGIPEFSHETADCQYLFSWYTSAVCPLGVGFDSENPGDDEQVHKGLSERSQAVGTVLSLLLVALTGCLLALLLYKKERRETVISKLTTCCRRSSNVSYKYSKVNKEEETDENETEWLMEEIQLPSPRQGKEGQENGHITTKSVKALSSLHGDDQDSEDEVLTIPEVKVHSGRGAGAESSHPLRNPQSSALQEREDDRAGLVRGEKARKGKFRSAQQKTVSSTKLVSFHDDSDEDLLHI
The following text describes a protein:
Function:
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
Sequence:
MQHNSVGPSSSTRKTTVTNSPHTAGSIHLHHRSSNGFNTSRTPLNRHMEMDLGKMFSAMEKGHKVCKIAVLKKWDPAYKQLTLDRYSRQIFLTKLEQSAVRNKPTILDIRQIREVQTLYYKLNTIKVDDKWKKDREIANFESKTILVISYGMAFALSNWILFVARKHMKPFVQTSLQFKVQSDQLQQVTEDQMDFDQFSYASRQLIHVPELFSLRFGDLAEKHDRKGLVVTFQNFLRFLDGKQFDDMASNRTRALEFLNRYFHEDQAYLGDRNEPSMTVLEFCDFLFSRENSLWDPTNEKVTHDMSRPLSHYWIASSHNTYLTGDQLRSESSLDCYAQALLMGCRCIELDCWDGQKKPGSNEFLDIVIYHGYTMTSKILLRDVLHVIRHYAFVTSEYPVILSIEDNCSVPAQRLLAQELKDILGDYLLTQPANREEKQLPSPAALKKKIIVKHKKLPVESEDLAAVVKTDEFQDTEIIARECVKKGILWMRNNNSHDWTSHVFILFPDRLCYLIETADPDNTSDDTVSVSGDEEREEETPSGFGVKPEEMHVTEEWFHGRCERDEAKKRILEHKEKGNGLFMIRDSNLFIGDFSLSILHDGKVHHVRIRSKIVDKEKKYYFMDNKVCDTLYELVSYYTRHYLTTAHFKMVLTIACPQPQPHLNQPWFSATADKEKAEELLSLIEEDGAFLIRTSSQDSSVFVLSLKVDGEFWHYRLKRDGRIFVVNQKVFENLNQIVEFYANREFVRGISLRYPVNEKDISHLTAELAEARTPGCYMDLKDLDKEVQARTLRPYRGTADDELSFPANVIITVLRKEEGLWRGRYGAMTGWFPSAHVQEILPEKTNASETSNYNTIELAGTLIERIHDFDKPHVIRISQSNQHWMSKQSYVLAANSSEEVEGWQNHLFELTRSVNTKMSILRTKEKEKRIAAELSNLVVYCQAVPFDPAHIYNDAFYEMCSFVEGKLDKLVEKGLLPFNSRKLSRVYPNGSRITSTNYSPVPMWNAGCHMVALNYQTGDKPMQLNQGKFLANGRCGYLLKPDYMLTDDFDPASSEKCVTTAYPIRLNVQVIGGRHLSRRDKNKGICSPFVEIEVIGMPCDTKVYQTKTIASNGLNPIWNQTFTFEIQCPEMALIRFHVEDGDFVGPKTDPFIGQAVFPVDSIRCGFRSVPLKNQYSEELELSALLVDVQMCSREGSQLIRSSSHFLQVSYFLKASRLAPVFAHRKITNGDSIPREMAPRLRTSATDRSLDSPTNSESRTTLLTSQRGSQDSMDSAAETTSIASGTVSSQNGKMKKNWLKKFSFGKSSKS
The following text describes a protein:
Function:
Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
Miscellaneous:
MISCELLANEOUS: L-homocysteine is bound via the zinc atom.
Domain:
Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin (By similarity).
Sequence:
MSSPLTDRSARLQALQHALRERILILDGGMGTMIQSYKLEEADYRGERFADWPSDVKGNNDLLLLSRPDVIQAIEKAYLDAGADILETNTFNATQVSQADYGMQSLAYELNVEGARLARQVADAKTAETPDKPRFVAGVLGPTSRTCSISPDVNNPGYRNVTFDELVENYVEATRGLIEGGADLILIETIFDTLNAKAAIFAVQGVFEELGVELPIMISGTITDASGRTLSGQTTEAFWNSVRHARPISVGLNCALGAKELRPYIEELSTKADTHVSAHPNAGLPNAFGEYDESPAEMAVVVEEFAAAGFLNIVGGCCGTTPAHIEAIAKAVAKYPPRAIPEIPRACRLSGLEPFTIDRSSLFVNVGERTNITGSAKFARLIREENYAEALEVAQQQVEAGAQVIDINMDEGMLDSKAAMVTFLNLIASEPDISRVPIMIDSSKWEVIEAGLKCIQGKGIVNSISMKEGVEAFKHHARLCKRYGAAVVVMAFDEDGQADTQARKEEICKRSYDILVDEVGFPPEDIIFDANIFAIATGIEEHNNYAVDFINACAYIRDNLPYALSSGGVSNVSFSFRGNNPVREAIHSVFLYYAIRNGLTMGIVNAGQLEIYDEIPKALRDRVEDVVLNRTPEATEALLAIADDYKGGGAVKEAEDEEWRSYSVEKRLEHALVKGITTWIVEDTEECRQQCARPIEVIEGPLMSGMNVVGDLFGAGKMFLPQVVKSARVMKQAVAHLIPFIEAEKGDKPEAKGKILMATVKGDVHDIGKNIVGVVLGCNGYDVVDLGVMVPAEKILQTAIAEKCDIIGLSGLITPSLDEMVHVAKEMQRQNFQLPLMIGGATTSKAHTAVKIDPQYSNDAVVYVTDASRAVGVATSLLSKELKADYVARTRADYAVVRERTANRSARTERLSYEQAIANKPAFDWAGYQAPTPSFTGVRVLDEIDLAVLAEYIDWTPFFISWDLAGKYPRILTDEVVGEAATSLFNDAQAMLKKLIDEKLIKARAVFGFWPANQVEHDDLEVYGADGETLATLHHLRQQTIKPDGKPNLSLADFVAPKESGVRDYIGGFITTAGIGAEEVAKAYEAKGDDYNSIMVKALADRLAEACAEWLHERVRKEYWGYARDEHLDNEALIKEQYVGIRPAPGYPACPDHTEKGTLFELLDPQGLSGVSLTEHYAMFPAAAVSGWYFAHPQAQYFAVGKIDKDQVERYSQRKGQEASVSERWLAPNLGYDD
The following text describes a protein:
Function:
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.
Subcellular Localization:
Nucleus. Cytoplasm. Secreted. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum.
Sequence:
MNAAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKIRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKEVYKEHFQDDVFNEKGWNYILEKYDGHLPIEVKAVPEGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGIALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTEAPLIIRPDSGNPLDTVLKVLDILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKKWSIENIAFGSGGALLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPGGNFVTLEEGKGDLEEYGHDLLHTVFKNGKVTKSYSFDEVRKNAQLNIELEAAPH
The following text describes a protein:
Function:
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of asperfuranone, a probable antitumor agent.
Subcellular Localization:
Nucleus.
Sequence:
MACPTRRGRQQPGFACEECRRRKARCDRVRPKCGFCTENELQCVFVDKRQQRGPIKGQITSMQSQLATLRWQLDRYLRHRPPPSITMAGELDEPPADIQTMLDDFDVQVAALKQDATATTTMSTSTALMPAPAISSKDAAPAGAGLSWPDPTWLDRQWQDVSSTSLVPPSDLTVSSATTLTDPLSFDLLNETPPPPSTTTTTSTTRRDSCTKVMLTDLIRAELDQLYFDRVHAFCPIIHRRRYFARVARDSHTPAQACLQFAMRTLAAAMSAHCHLSEHLYAETKALLETHSQTPATPRDKVPLEHIQAWLLLSHYELLRIGVHQAMLTAGRAFRLVQMARLSELDAGSDRQLSPPSSSPPSSLTLSPSGENAENFVDAEEGRRTFWLAYCFDRLLCLQNEWPLTLQEEMILTRLPSLEHNYQNNLPARTPFLTEAMAQTGQSTMSPFAECIIMATLHGRCMTHRRFYANSNSTASGSEFESGAATRDFCIRQNWLSNAVDRRVQMLQQVSSPAVDSDPMLLFTQTLGYRATMHLSDTVQQVSWRALASSPVDQQLLSPGATMSLSAAAYHQMASHAAGEIVRLAKAVPSLSPFKAHPFLPDTLACAATFLSTGSPDPTGGEGVQHLLRVLSELRDTHSLARDYLQGLSVQTQDEDHRQDTRWYCT
The following text describes a protein:
Function:
Required for the insertion of integral membrane proteins into the membrane. Probably plays an essential role in the integration of proteins of the respiratory chain complexes. Involved in integration of membrane proteins that insert dependently and independently of the Sec translocase complex (By similarity). Addition of green fluorescent protein (GFP) to the C-terminus leads to photoinhibition at 80 umol/m(2)/s light intensity, reduced amounts of pigment, altered energy transfer between the antenna systems and the reaction centers of PSI and PSII, and impaired integration of PSII reaction center protein D1 (psbA) into membranes, suggesting it probably also aids protein insertion, folding and/or assembly of membrane complexes destined for the thylakoid.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDFGIGFISTNIMLPILDFFFGIVHSYGFAIIALTLVIRLGLYPLSAGQIRNMRKMRITQPLMKERQEEIQKRYKDDPAKQQEEMAKVMKEFGNPLAGCLPLLLQMPILFALFATLRGSPFSDINYTVDLQILPQEQVERIVPQTFSTKPQNIYVDEALHYPIAVFLPGGKMLGVGEKTQLEIQSTEGKAFNQVIPEKNSQILTPTYSVTKGEDRISVNPDGTIEALVPGDATVQVTIPGIAARTGFLFIKALGQVGVTGENGEINWDILGMIVFFGFSIYLNQELSGASGGGAPNAQAQQQQTINKITPILFSGMFLFFPLPAGVLMYIVMANVFQTIQTLILMREPLPENLQKLLDEQQKATQGRESLPFEKKSSKKKEKTS
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MVLSTEGATNSVEVVAFSFLTDDEIRRSSRVKITNPILIFNLSCTYFTCLELSCKSCGQTTKHCPDHFGHIELVSPVYNPLTFNIPSNILQRTCFSCHHFQSLRKEVDIRAFQLELIMKGDIIMAKNLESIITEKSNSVLRKFLTKKHKCQECGAENPRISKPTFGWFYMVLQCNISLGDAHLNKSDPSKVLSWWMDLQQSVNMLFDNKTASGKRDVATGICRLLEKKEGIFRQKMMGKMVYFACRSVISPDPYLAVNEIGIPPYFALRLSVTPWNVVKLRNAILNGAESHPSASHYADKVSIVKLPPKGKEISDHEFEGKVVYRHLKDGDVVLANRQPTLHKPSIMAHIVRVLKGEKTVRMHYANCRVTTVNNFFVLFFPLRDLCTYNADFDGDEINVHFPQDEISRAEAYNIVNANNQYVKPTSGDPIRALIQDHIVSAALLTKKDTFLSYEEFNQLLYSSGVSMAGLGSFYGKHGQKVFMSNSESEMFLALLYYITRGSPSFTVEKNAKIPSNFFKTRIRKGKRYTQDTSKKKEKPDEDKLLIYKNDLVLQELYGSNVAGNLLSALSRLFTTFLQMHGFTCGVDDLMLTEGKDVERMNQLNSCEIIGNSVHREFIRVKNSDNIDSVTLQLNIEKKIRSNGEATLTSDRKMTNKLNSTTSSGILKELLSEGILQPSGKNCISLMTTSGAKGSMVNFQQISSHLGQQELEGKRVPRMVSGKTLPCFPPWDCSPRAGGFIIDRFLTALHPQEYYFFDTAVKTSRSGYLQRCLMKNLECLKVCYDHTVRDADGSIIQFHYGEDGVDNKELVYSNYCRQLDRSSPYINKLPDALEGKAEKFSKQRNLGSMEHADFVRLIEHKYVSCLTQPGEPVGVLASQSVGEPATQMTERGEESSYSKSNSKMSFLLIVLTKILMAAARDIKTPFMTCPLRHEKSINLKKITVADIIKSMKVSVVPVTVLGGQICSIYKLVMKLYKSKQYPEYTDITLEDWEETLRVNFVRDSEDAHDNGSESEKKGQSNDEDDDGVVVEDTEGNEDLGSDAQKRKLQGTDEVDYEDGPEEETHDEKKKSEPTKRYDWAIFVEAKGMHFEIHFRFTGEPHILLTQIVQRTAKKFCLQNFGKVGECKAITCKESGVIYYGKDDRKGDEISAFEKEEIPALQTSGVHFKTFWELEDDLDVRYIYSNNVLAMLNAYGVEAARETIIREVQNLNADFMTHSGGYCLMNRTGSIADSTSLFIKMCFETAAKFIVEAAYHGQVDNLETPSARICIGLPVKMGTGCHDLIQKLEI
The following text describes a protein:
Function:
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body).
Subcellular Localization:
Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus, nuclear pore complex. Nucleus, nucleoplasm.
Sequence:
MFGQQKTPFGGTTGFGTTTKPFGAAKTAGTGAFGTSSFGATQTPATGGLFGGTATNTGTGLFGGTSFGTPSTSTSTFGGFGTSTTQTGGGLFGTSTSTAGTGLFATPQQQTAPFGAANKTGFGGFGTQTSTAATGTGLFGATQQTPSLFGGGQTTSTGLFGAVGGIAAGTNGTTVKFNPVSGSDTMMKNGVSQNIRTAHQCITAMKEYETKSLEELRVEDYLANRKGGSTGTTAMFGGTATPQTGGGLFGNTATTTSTTGFTFGKAAFGTGQTQAKGATGFGTTSTGTGLFGQTQTTQAGGLFASPFGGTATTTTASTGFSFGQTNTGTGLFGQTQQKTGLFGQPTTQTTGLFGTPSTTTTTGFGTTFGTGTFGTQNQAGGLFGANKAPTFGATTTTSTAGGLFGNTATNTGGLFGQNKPGLTLGLGTGFGTGAFGTTTTSTGTSLFGPKPTNTFGAGLGTGLGAGLGTLGTGSIFGNTGLGAGIGTGTTGLNLTQPAAALGTDAAAQLAQQAQIQQQLQALSNSPFGDSPLFRNNVADPAKRAELLKPTSLAAQKALTTPSHYKISPRPTAKIKPKPLHSLVAGKSQLFEGLDDEDTSLSNDTFVPRRSVKKLIIKNKASPTASELDAGLGEEDDLLAPPAYPSDTFLVEDKRTSESEKENDPMENLYSNPVRKPIPETPANKSSPAPDDSIIALNLRQRSCSPGQDSMGEPTNDDQGEVEDEVEREPHPAGIILTKNEYYTEPSLDELANMVDENGDCWVENFVIGREGYGSVFFPGLTNVANLNLDETVHIRRKEITVYPDDSTKPPEGDGLNKKAEVTLHCTWPMDKTAHIPIKSPDRLKKMGYQEKIEVATSKIGARFLEYRPDTGSWVFQVPHFSKYGLDDSEDEEELVGQEQKKMKMQQQADLQKQQQQKENQPPSLNKQQPITERVKSEQPIMEQMQDDSDMADISQEPIPDLAPNSSGDQDGLEGLSEEEVVPSSHRLATHLGMSAHRMQVMKASFFGDEEEGEGMDYKPVFGGMSGRSSLRGSAPPSGSASPLPHRMAEAKMDRGSFLAHTARLGSLASPVRGLGGMSPSHSPRTRIPSGGFSPKYSPKVEQSGLFPSLSKPAQYPVFERNQGLLLPSGLSSEIERPRKIVGSQRQPMLLPWKQTVTNEKQSLVADAALMMGRSFKVGWGPNWTLVRCAGADREEAPERKKETSIPFSILPKSTPRLAKLGTSSPFSVVMERVDVAPHFVVQDKVTVANHVSHLEVELETSLCSTEDHPCPVFVPTPGVNALHQHADVACRNRENTGVRHPERESADHASLVLSLCVALWGDLPDQDREDGEDGLDMTSYAYHMARREAVSHWLMNQAQDTIEQEVQDSKFKEGGHTDAIFSLLSGRQISQACSLAQQSGDHRLALLLAQASGSHFPRELVGKQLSDWEELKADRFISDSRLRVYALLAGKPVWPTTNGEINTCENLDWKRALAVHLWYLCTPSATVSEALQLYCKAFTKNNSDYGEYANPPLPPYLERSADRSGDQEDRYVIRDMCYHLLQLYADRSHQLDRLLAPTTSTPNQLDYRLSWLVCQALQALDYTHLSEHHLNTIHAGYIAQLESLGLWEWAVFVALHITDNSRRELVTKELLCRHCSLSEEEAYVQKEEFLQEKLRVPVVWIHEAKALRAQYEGKSHDEAWHLLKAGKWNASHRIVLKHLAADAIINEDYEYLKEFLEELSPPDRSSTIQDWNFGGRVFLDYILINNALVEMAKGNSSSYDLERLHPQVTSLCSRIENIPCLTPKDRLCQSEMAKKAASFLRLVLEGQNKPPTVDGEYLVPSYQLAPHITKLPMPEDYALQELRALTHSYMMELTT
The following text describes a protein:
Function:
Functions as a zinc transporter.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MLAATVSTTCIHPALPLPIHNPSHSRRETAHLPSAQTESRLAQEGPHLNRYLMASTYALPIAPTSHAHSHERSQSQYSPYTNGPHSSPLRANGHRHHQSDMSGNGQLHGAVRSPYAEYNGHAHEHNHTHSHDRSNSNDSSWTLQPFVNGRSKGRPRGEAEIGRSPPRKNAAAKYGFSPVSPIQESEQPILPVLSSSWLELPEALTALLIPLPFLFASLAYPTVIGRNQKLPSTLSEAVADSAPAVESLAVTSHSQLLHALTLSSATLILVGVIAKISSSLQPLDRRKSDATPGTFNLSTAPKRMAYNVLSVLLPFYASMQLGGARVALALLTAVAAGLGALDRKPGKHTPWDDFRRTLRTRKITCGAVALAMVADSLAVGSASHPLFGYSSLLMSIFLVPPPLPTAGWSLIMGSQGQTSYVSQGSGRASLPKPYSPLISSFEDTVLTIASGLSLTVVALLYSLVSSSSPSFSHHTIAYTTLSIASATALVFLSLPTALRSQKHVGLALGTLLVAAVHSWEQYSTSTVLWVAFPLACVGLLGAVIVLIEKDSRRIAYFGVLNLSFMIVQFFYGFVSGSLGLLTDSIHMLFDCAGLAVGLAAAVMSKWRPNARFPYGYGKIDTLSGFANGVFLLLVSVEIIFDAFERLWEGHELRRLNELLIVSILGFLVNIVGLTAFGHAHHGHGHDHGHEGHDHGHGHSHDNENMQGIFLHILADALGSVAVIISTLLTKYYGWSGWDPIASCIIAILIFLSAIPLVKSSGARLMLSLPNDLEYRVRNTLGELGTLRGVVGYAVPKFWLEDEGAAHAEAHAKEADHDCGHNHAAHPQRVLGVIHIIASHAADLEDVRVRAVQFLRDRGMEVVVHVEKEGEGRCWCGGGVKAN
The following text describes a protein:
Function:
Transcription factor. Acts during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR). Required during mitochondrial stress for the activation of genes involved in the mtUPR, in concert with histone deacetylase hda-1. In response to the citrate-induced mtUPR, positively regulates transcription of transcription factor nhr-80, thereby leading to modulation of lipid metabolism. May play a role in modulating the decline in protein homeostasis associated with normal aging. Required for embryonic development and maintenance of mitochondrial morphology.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol. Note=Upon mitochondrial stress translocates from cytosol into the nucleus.
Sequence:
MFPMRVIVETVRSQHCLTCSNEGHMITDTYAIVAGTTTLNQLVETVLAALGHSSMSTSARGLIQVNNWKPLPFDQITENLDDTVENLFKDISSHVVLKILSKPSTDSNSVQCISEVKNKLLKAAVNKNPNVLTNVDNQQVKDVINTIIAGDETLLNSEQIGAVNEWLDTLETNEDRRSPTQVQRFNTLYEIPRLDKWFKSDANPSKQKMNNYLSQLNQSPFRKNNSKISYQQICNWFTQKRSSSRTLAPVDLVQVSSAQTAAQLLPGFQLNLLQSLFGEQRQKFDFYDKLDETKIVGGSDSPSPADDEIHSNSDETIQDTLFSINIKPEPEIDSIASSPDMANSMRESLSSTSPKLLSGLDLGAFSTHSSSTNSMQNANSSVFSAARSRLMFDPLTELPVLEKWFEENPHPTWMQIDQYTQCLNNCAYRENYPHISQHNVKIWFKNRRAKCKRLLNGMQEKLEQKVFV
The following text describes a protein:
Function:
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MDIFRVLTRGASVKKDGKQVDFSRVQSQRTARPGQRGKDEDEEQLSRELDFFRTRRSVPAAAERPAEETGDAHRDETEQDEGAEDVAPPPRITTAEEASQLRRSYRGKVTGADAPLPIGSFEDLVTRFKLDKRLLSNLIENNFTEPTPIQCEAIPISLQNRDIVACAPTGSGKTLAFLIPLLQQVISDKAVGTGVKGLIISPTKELANQIFDECSKLAQRIFLEKKRPLSVALLSKSLAAKLKNQIVSDKKYDIIISTPLRLIDIVKSESLDLSAVKYLIFDEADKLFDKTFVEQTDDILSACSHPNISKVLFSATLPSSVEELAQSIMTDPVRVIIGHKEAANTNIEQKLVFCGNEEGKLVAIRQLIQEGMFRPPVIIFLESITRAKALFHELLYDKLNVDVIHAERTQVQREKIIERFKSGDLWCLICTDVLARGIDFKGINLVINYDVPRSAQAYVHRIGRTGRGGRKGTAVTFFTKQDAIAVKPIVNVMKQSGCEVAAWMENIAKMTKREKEMIKKGKAFVDRKQISTVPKILKQKKRQQKEMIEASKKRKLAQQAGDASEEEHA
The following text describes a protein:
Function:
Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Exon 14b skipped; MISCELLANEOUS: [Isoform 3]: Exon 14a skipped; MISCELLANEOUS: [Isoform 4]: Exon 5 skipped; MISCELLANEOUS: [Isoform 5]: Exon 13 skipped; MISCELLANEOUS: [Isoform 7]: Exon 13 skipped with exon 14b.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, spindle. Note=Associates with several components of the cytoskeleton including ciliary, random and polarized microtubules. During mitosis, it is recruited to mitotic spindle (By similarity). Membrane localization is dependent upon cell-cell contacts and is redistributed when cell adhesion is disrupted after incubation of the cell monolayer with low-calcium/EGTA medium. Also nuclear and perinuclear.
Domain:
The D-box 1 (destruction box 1) mediates the interaction with APC2, and may act as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Sequence:
MNISEDVLSTGSSLASQVHAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRKEAEQQKGQLDTDPPRSHCSSSAPVLPCPPSPQNEGSKQDATPSKQPPASHTVQSPDPEHSRLPGRCPGRASQGDSSIDLQGTASRKPSETPIEHCRGPSACVHPRSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEEGPSSARQPLCTGSGRPAEKGEDSSPAVASASQQDHPRKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRSKVTQDKLIGGVSSGLPLSTEASRSGCKQLYEDICASPETGVAHGPPPGQCMNIHLLPVEQRLLIIQRERSRKELFRRKNKAAAVIQRAWRSYQLRKHLSRLLHLKQLGAREVLRCTQVCTALLLQVWRKELELKFPKSISVSRTSKSPSKGSSATKYARHSVLRQIYGCSQEGKGHHPIKSSKAPAVLHLSSVNSLQSIHLDNSGRSKKFSYNLQPSSQSKNKPKL
The following text describes a protein:
Function:
May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.
Subcellular Localization:
Nucleus.
Sequence:
RELDMGAAERSREPGSPRLTEVSPELKDRKEDAKGMEDEGQTKIKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQLHKGVLIGAASQFEACRVAPYVNVGALRMPFQQDSHCNVTPLSFQVQAHVQLDSAVRAAHHHLHPHLAAHGPYMMFPAPPFGLPLATLAADSASAASVVAAAAAAKTTSKNSSIADLRLKAKKHAAALGL
The following text describes a protein:
Function:
In vitro, is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose and methylglyoxal in the presence of NADPH, albeit with poor efficiency. Shows only trace activity with benzaldehyde and butyraldehyde. Is unable to oxidize myo-inositol with either NADP(+) or NAD(+) as a cosubstrate and also does not use glucose, 2-pyridine carboxyaldehyde, fructose, xylose and succinyl semialdehyde as a substrate. The physiological function of this enzyme is not clear. Does not seem to be necessary for inositol catabolism.
Miscellaneous:
MISCELLANEOUS: The 3D-structure shows a unique architecture for an AKR active site, which may explain the low catalytic power.
Sequence:
MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREAIRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDFLKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLEQLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTEDTTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDILIPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA
The following text describes a protein:
Function:
Receptor for tachykinin-like peptides.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MENRSDFEADDYGDISWSNWSNWSTPAGVLFSAMSSVLSASNHTPLPDFGQELALSTSSFNHSQTLSTDLPAVGDVEDAAEDAAASMETGSFAFVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFNYYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQPRMSKRCNLAIAAVIWLASTLISCPMMIIYRTEEVPVRGLSNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFLPIVSMTVTYSRVGIELWGSKTIGECTPRQVENVRSKRRVVKMMIVVVLIFAICWLPFHSYFIITSCYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTEPFSRRENLTSRYSCSGSPDHNRIKRNDTQKSILYTCPSSPKSHRISHSGTGRSATLRNSLPAESLSSGGSGGGGHRKRLSYQQEMQQRWSGPNSATAVTNSSSTANTTQLLS