lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDEIQESSCNEKLSDEDLAAEFVEFTDNIPIEIYRSLRYIRKYENFFAKENENLNTAARLVCDCPISEVPSAKQKLADSLFTSHEYLRQTSAEANKLYENVLASYKHLCEKIKYLEADNPLYVPAP
The following text describes a protein:
Function:
Crystallins are the dominant structural components of the vertebrate eye lens.
Sequence:
MGKIIFYEDRAFRGRCHERSSDHSNLQAYFSRCNSIRVESGSWMFYLRPGDYPDYQHWMGLSDAVRSCRLIPAVSNPCPCTPRLISGNWDPQGFFLGLQHDCPASVQHHRIRLSLLSVLEGCWILYEMANSGAGSFCCGLASNGRFPDWGAADARAGSLRRVLDLYGDPFARILHLAVNKGFPV
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
MFQARMIRARAVRHARRFFHHQKDTFACERRCRHGCLPVSTLAQRHNSSGRTVNAFAEDDLLHKKGLLVQGADGKSPPVIDFSKAEIIFKQKATLELGRSFVVLQMCSFNFLVDNSFKLMTLGLRVMGETLFTALMRASFYGQFAASPQSVRQVANKFNAADIAPMLATTAEEKVGDSPDAINEEKYERNVETMLLCLDMQTEVARPNQPILSQLRITSYIKADLLARLSDILATMDNNFLTDNPVCVANLMNGLDGDLMDIPELTDMELTHLKHALKRIDTVVQRAIQNGIKTLVDAEYVSVNQAMSLITLAIMKKYNSKEPLVWNTYQCYLKDALVNLKRGVAVADAEGFQFGVKVVRGAYMAQERETARLEGLPDPVNDTYEDTNNMYDTVVAHLLDLVHQRSSNSVNLIIATHNIESVSKAMKRMWELGLPPREGSVVFGQLMGMCDHVSYGLGQAGYLTYKSIPFGCMEDVLANMSRRAQENKTVFHRLKQEKKMLRQEISRRTLSISQ
The following text describes a protein:
Function:
Acts as an orphan toxin which is important for maintaining cell fitness during stress related to the stringent response (decreased amino acid, purine and thymidine availability). Overexpression inhibits cell growth and increases the formation of persister cells. Causes 99.9% of cells to undergo bacterial lysis within 2 hours after induction; nucleoids condense, the cytoplasm seems empty and the periplasmic space enlarges. The intracellular ATP level decreases about 27-fold suggesting the membrane potential may be disrupted.
Miscellaneous:
MISCELLANEOUS: Although this protein has high homology to GhoT, the toxic component of a type IV toxin-antitoxin system, no antitoxin has been found. GhoS (the antitoxin for GhoT), YdcY (the neighboring gene), 5'- and 3'-UTRs as well as approximately 620 bp lengths of the BW25113 genome DNA were tested.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSLYQHMLVFYAVMAAIAFLITWFLSHDKKRIRFLSAFLVGATWPMSFPVALLFSLF
The following text describes a protein:
Function:
Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate.
Subcellular Localization:
Mitochondrion.
Sequence:
MSYQYLKQVRKIVCIGRNYAAHIRELNNPLPDSLVYFLKPTSSLVTPVDAAVPTAPEDPSHVLRADGTNPGPILVPQGVEVHHEVELALVLGKRLSNLLPSEFGPEDVYGAISGVALALDLTGRNLQAESKRKGLPWTAGKGFDTFTPISAFVPREALPSRDLQNSFTLRCAVNGVQRQDASTALMLTPMHQLLQQLSAVMTLEPGDIVLTGTPAGVGPIIPGDHISASLLQDKKQLAAFAFDVRTRPGPYMYNSKL
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MENKENTLNGVIPKPKIRVVKKVIRKKPPMTSDNSDPSTNKLNEQLSNLKLDSSNNSTTTNNTTNTTINTLNKPNVQKKSDILKKSIKEKIHFDKLTYDAQMSLIEDETTENELRSHYYNLFQPDHFKDVVAERSASGKCGYPCCSKPLGVKKLNQKYFISVKEQKVYNVEELSMFCSSDCLVKSKLYASTLDETAVYLRNVESKKILPTEQTLISSQTKTQSQTQTQSQQAPKPASKPIEFLNKFEKSLVITENENASLIPPNLTFDKNVDNEKTKIDKQPQKSTTTNKTISKPKKKTIITDDLKVPIEKKEIKIRDSDDEEDDDDSDLNYYSEDDTLLGDEQDDAPMVLNEDEDENDNNINEDEEDENKSDKSEDEFSLFRPTQMSSKRVEELFKPHISNYHMVYSTLSQFTTKHTNNFLQFNQINYEYILEQNLQIKSNLHSQLSLVYQSVIDQLGFKITTAKEKVTILIDTFKFDKPVPSLRRNHWKILSSIDEEILKDIKDNNDKFENLVKECNFDMETLKVFQDLLIQGYQ
The following text describes a protein:
Function:
Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium-sensing proteins MICU1 with the calcium-conducting subunit MCU (By similarity). Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Note=MAIP1 is required to assist sorting of EMRE/SMDT1 into mitochondrion by protecting EMRE/SMDT1 against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB).
Domain:
The GXXXX[G/A/S] motif at the C-terminal part of the transmembrane region mediates interaction with MCU and is required to activate the calcium-conducting pore in the uniporter complex; The poly-Asp region at the C-terminus mediates interaction with the polybasic region of MICU1.
Sequence:
MASTAARRLAWVAVRPGALWSGPRGRRGGDVYTVPGSSGLSQVPSRSVIVTRSGAILPKPVKMSFGLLRVFSIVIPFLYVGTLISKNFAALLEEHDIFVPEDDDDDD
The following text describes a protein:
Function:
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
Sequence:
MFGFEIQPVRSRNWEIEEEEDQEVVSVEIPKPSISFVNDNYKLEFNNNNDTPFNIIVSTNGSPSIFVKGCFESNQFDEIADISYSDIKPLKTTNTNTVLNNKCTVYRHKIEKSMIFITVQYDLPSERCFGFTELVLNTFKNVSQVLVLDKILNTHYLSQNYTHPIPPFTRAIFNSLFKNDYSLTPLESSNIIENLSASFLTICQVKYIPACSILNLYESHLNIESVQSFTPIVKSIYPQLFNNSSLKQEDITSQFKLMINALNKRNDKGMYM
The following text describes a protein:
Function:
Component of the tel2-tti1-tti2 (TTT) complex that stabilizes protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC) (By similarity). Component of the ASTRA complex involved in chromatin remodeling (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MQYYKELARRLHTLQSKNEKEALEKQIDFLDKLVVEVDSLVHEQDLRPLLEFISPTESWFLLGTATIFYIKLLTHPDPESIDVVIKEAYVVRAHRILSIFQEQFIENVVKEINWEILAILISLSGIENGLVRNLSEFLSTSILSAVPRQKFLLYLLEKYQINLFHREERLTDQGRPVAFELPPDKFHSDQSKALLEPKWKTKNYLISHLIFWIIDQQSSSSIEVCWHRIIPSVLRILNDLSPNIKLQGIELVNRLLKITEREFLLYTGILKILKDDLLVFYTFIPPRFTIQTSVTLINASFATLVSLYPEENENLNSIMLNGINSVFQFAFDYPLILQAAFSQIMVLTDKMNVSYLPYLTLTLDELCRIIQNPQIIQIPSTLSFFLEILTKLLEIYSYRISAHHVELLMALVVCSRNYMRCNLQEHHNAIVQALQNLFTLIKLNITVEQLGDYNVILPLLEPLQIPL
The following text describes a protein:
Function:
One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular Localization:
Membrane; Single-pass membrane protein. Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MLNIFSLICICLNSALYSSNFFFTKLPEAYAFLNPIVDVMPVIPVLFFLLAFVWQAAVSFR
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes; Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MATGAEFRQDMPPKGGYRAFNFHRTFPKLVWSPGTVVAAIFGATAYGVYAALEGKKKDITEKFEDVDINNAMEPFLTAERDRYWLKLLAKNRALEEEIMKDVPGWKTGTWYGEPVYFTLGDKWWDPTATEVFVHSRGSNETRDHLWRQHSEYAGPKFYDNWFPQWMSKWFW
The following text describes a protein:
Function:
Substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity. May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein.
Subcellular Localization:
Cytoplasm. Membrane; Lipid-anchor.
Sequence:
VETVVSHDRTTALQPGRQETSSQKNIYKKHIERSLPHQFAPLGTGGGCAVVVVAASGCHRPHQLPAPGLLSAAVGRTNHCTTDPFGINHGIGPHPDVVEYAKEKLQSFIKNSDSFDKFEFCEPAFVVSNCLQIASDSHRYDGIYCGAGVQKDHENTTISWRHISHAYRGSVNTEPGKTLGKGKISLFCHLLHLCNQVRMIMANQILWDSLPVLSGIYRIWLVFTFDAHLEIA
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGNKPRKFSLGGIVDCTTRAGKEERVAMEMALQDFYSNATQRPRLCVKDSKGDSFRAASSAKTLIKKHNVEAIIGLGTSQEAILVAELGNRYEVPILSMVNEVPVWASLRWPFLINAARNQLSQMKAIAAIVQSWQWRRVNVIYEENKINSIIPHLFAALQDADAEISELLPFPPSPPYRFLSEKLVSLRNGQCRVFIVHTSATLARSIFREAKKLEMMEEEYVWITTDSTSDYFDTFNNSVLSSMQGALGVKSYISSSSKRIKDFRSRFQVMFSSQFPEEPFPEPGISALQAYDATWAVALAMEGRPSSKRFGNSTSITPKASMGGTSLLNRILASKFEGLTGHICFINGMLHPAARIFTLVNVVGISTELGYWTDGYGFSKTVGANIHYNKSITVLRQIIWPGGPWSAPRGWASAAGGKRLKIVVPSGNSHKEFVKVSYDGPGGSIRVTGFVIDVFNATLSRLPYALPCDFTGYDGSYDALVYQVYNRSFDAAIGDTAILANRSKYAEFSQPFTEPGVQMVVYQESKKINKVRLFLKPFTGKLWISIAAITLYNGFVVWLIERQKDNPDFSGSCNLSRMVMVAWLFVALITTQSFTANLSSLITLQQLNESPVTIDTLKKSSAKVGCDEEYAAALINGSIAAAFLEIPYIKAFLAKNCNGFTTSGPIYKVGGFGFVFPKNSPYIPDISQAVVNISETLIDLLQISLHSSECSASNSDDHASIGLTPFIGPFLVTIGTSSIALFLFYLPSICQIWRQHWPFNNDEQEPQQELELQRSWRHDRRFDEQILFASEMENRGAWQ
The following text describes a protein:
Function:
PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1) (By similarity). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). PACAP exists in two bioactive forms from proteolysis of the same precursor protein, PACAP27 and PACAP38, which differ by eleven amino acid residues in the C-terminus (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MTMCSGARLALLVYGILMHSSVYGSPAASGLRFPGIRPENEVYDEDGNPQQDFYDSESLGVGSPASALRDAYALYYPAEERDVAHGILNKAYRKVLDQPSARRSPADAHGQGLGWDPGGSADDDSEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIPYL
The following text describes a protein:
Function:
Required for telomeric clustering (bouquet stage) during meiosis 1 prophase, formation and efficient homolog pairing, meiosis 1 disjunction, and telomere deletion during meiosis. Also promotes meiotic recombination.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MSKDNRLASILLQPVASSSGNCTEFHDSKLHTLQEELNFLPLEGVASNVCPPMFRGHKNYVFVLYCLNQVDLVTNLQDSTKRYYPLQIFKDCQLSSLVQKDFSHYFQLSRQKEGEDRNDSDTTLVNVVNSGVSRHRSQLLKMCIIPRICSFDKSNSKTYKLIQEYVNRFETVLTKFGPEKDFTKVYANWSKLIESFNELILHDLLVKWQQWSELTQPNATVHQNIPNVLRELVIKLTQRYFTFQPSYSCSIDEFTTILLNKNALSLLDVFRKPRKYKLNFGLWLDCQNGILIFTNGIVQMADEITSERVKSFVRPAHLLVLEDHSNDEAVKKLMFFTFSAILQCFTDEILNC
The following text describes a protein:
Function:
Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MDSAERSRKRAQRWSKRKAVVVHLAVCFVVGALAPLAATRGPGIRDGGVQRVAPPSPPAAPDIGLLLIVTVTRPDEDGMLQEASLTRLGHTLRLVPPPLLWIVVGAENRSASTVQVLRGTGVMFRHLTYAVDNTTGNAGDEGDLKRNVALSHIERHRLAGVVHFAATSAIYDLRFFEELRQTRGVAAWPTATVSSADQRVTLQGPTCNSSQITGWYSEDSGINATATHTTDAAAAQDTGAIRNSSCLPPEISISGLGFRSSILWEWFINSNISSGGSSQDYIQLVRQMAVGDEDGWKGIPSDCSESRIMMWHLEMPKHTPEVEEQETPREQSLLEEDEEDYMN
The following text describes a protein:
Function:
Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of germ cells. Associates with specific target mRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MIMATLVTRKDIPPWVKVPEDLKDPEVFQVHTLVLKSLFGPQGSRMPHIEQVSRAMFELKILESSGLTEVLIYGSCNHKLRAKWMLQTMAERYRLRQERGMLKLEEAMKTLELGQCLE
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MRNQRFSLLKEPISSTLNQHLIDYPTPSNLSYWWGFGSLAGICLVIQIVTGVFLAMHYTPHVDLAFNSVEHVMRDVEGGWLLRYMHANGASMFLIVVHLHIFRGLYHASYSSPREFVRCLGVVIFLLMIVTAFTGYVLPWGQMSFWGATVITSLASAIPVVGDTIVTWLWGGFSVDNATLNRFFSLHHLLPFLLVGASLLHLAALHQYGSNNPLGVHSEMDQISFYPYFYVKDLVGWVAFAIFFSIWIFYAPNVLGHPDNYIPANPMPTPPHIVPEWYFLPIHAILRSIPDKSGGVAAIAPVFICLLALPFFKSMYVRSSSFRPIHQGIFWLLLADRLLLGWIGCQPVEAPFVTIGQIPPFVFFLFFAITPIPGRVGRGIPNSYTDETDQ
The following text describes a protein:
Function:
Catalyzes the first step in maceration and soft-rotting of plant tissue.
Subcellular Localization:
Secreted. Note=Upon overexpression also accumulates in the periplasm.
Sequence:
MLKTISGTLALSLIIAASVHQAQAATTYNAVVSKSSSDGKTFKTIADAIASAPAGSTPFVILIKNGVYNERLTITRNNLHLKGESRNGAVIAAATAAGTLKSDGSKWGTAGSSTITISAKDFSAQSLTIRNDFDFPANQAKSDSDSSKIKDTQAVALYVTKSGDRAYFKDVSLVGYQDTLYVSGGRSFFSDCRISGTVDFIFGDGTALFNNCDLVSRYRADVKSGNVSGYLTAPSTNINQKYGLVITNSRVIRESDSVPAKSYGLGRPWHPTTTFSDGRYADPNAIGQTVFLNTSMDNHIYGWDKMSGKDKNGNTIWFNPEDSRFFEYKSYGAGATVSKDRRQLTDAQAAEYTQSKVLGDWTPTLP
The following text describes a protein:
Function:
DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MPPINIEAARRIQERLARQVTYAPLPPVETVAGLDVAYSGSLAFGAAVVVKRTTLEVVETACSVSRIVVPYVPTFLAFRELTPMLRAYIKLKSKPDVILVDGHGVAHPRRFGIASHIGVVLKKPTIGVAKSRLYGEEVGDKLVDPATGEVLALIIKCGGKKYVSVGSYATLDEAAGLVAQLCKSGDVYPLRLAHELANKLKKAHLPDDKDRDSCP
The following text describes a protein:
Function:
Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation.
Subcellular Localization:
Prospore membrane. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the ends of spindle microtubules in cells in meiosis. Localizes to all four spindle pole bodies during meiosis, ADY1 is required for this localization.
Sequence:
MPEDTSYSNSFEDYYNNSHAISPYKDSFYKEMTPSKPNVRFGDDDVNIFDQRKKVNEINKNNTVKRSIPSSISTTITPNKSSLKSPRGKRASKNSFDNETKLESKNETLKEVNDAVNRCYALCNIPTKHVSINSISDLAQTFETLAVGITHETNRKAECERSKNAIDSLYYHEQLEKKELNEKSLQMAIDHLLKVTKQNLRQADDGNKLKETEALKSFIEEIEEVDDNKISINSLQQQLLEEKTANNILRRDYYKLQERGRRLCHEFQELQDDYSKQMKQKEYEVQKLKNEIKVLLNMNDNLKAEKAHYSQKEKQYFQKYTYIEKYMNHVKEEYNRKEDECKKLNFIIDKSMKKIEHLERSLQTQFTAQNSFSTAMIQEEGPKDAHLKDRYHKVKEFMEQKLQTSKINDPSCSEAEALDNVLCLIESSMKTLDKNSKCYPIATKKCIKYVTDSPRLKENEHVTN
The following text describes a protein:
Function:
Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion proceeds through several steps; first mitochondria are tethered together, then brought into close contact, followed by the formation of a docking ring around contact areas, and finally membrane fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondrial morphology, which is balanced between fusion and fission, mediated by FZO1 and DNM1, respectively. Functions antagonistically with DNM1. Probably acts by forming membrane contact sites that mediate mitochondrial membrane fusion. Mitochondrial docking and fusion requires GTP hydrolysis. Mitochondrial fusion also promotes increased lifespan.
Miscellaneous:
MISCELLANEOUS: Present with 1000 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein. Note=Detected at the periphery of mitochondrial contact sites that form before mitochondrial fusion.
Domain:
The GTPase domain may regulate the interaction with UGO1 since FZO1 lacking the GTPase domain binds 5-fold higher amount of UGO1 than full-length FZO1. The coiled-coil heptad repeat domains HRN, HR1 and HR2 are required for the oligomerization and function in mitochondrial fusion.
Sequence:
MSEGKQQFKDSNKPHKDSTDQDDDAATIVPQTLTYSRNEGHFLGSNFHGVTDDRTTLFDGEEGRREDDLLPSLRSSNSKAHLISSQLSQWNYNNNRVLLKRSILKTQAFMDQLQEENNIRPIFIAANDEREKLHVLQLNIKLDGQYNTKEKNGFNIEKKALSKLFHSQIVSVTNHLNALKKRVDDVSSKVFITGDVNTGKSALCNSLLKQRLLPEDQLPCTNVFSEILEARENDGIEEVHAIPLNIAPTLKEAIDMYSIQNPKTYEIHTLKELPDLVPQNGKYALLKIYIKDDKRPASTSLLRNGTVDISLIDSPGLNMDSLQTAEVMSRQEEIDLVIFVVNAENQLTLSAKEFISLASREKKLMFFVVKKFDKIRDKQRCKELILKQIRDLSPETYKRAADFVHFVSKNGDELPHYHNENDNEDHGDRKPDDDPYSSSDPDPDFDSLEDSLRNFVLKKRSLSKLLPAKTYLSKLLSDIIMISKSNMKMYSEEEIKINEQLETLRPEILSARAKCNDLTTSVDQMAEQTITMTYNNTKEALLNALDVPLHEYPKYQGLGQIYDFIFSTEAFIANQIDESIGSSELFAKQKTDLLVKKIYEIGKNELGDDFMCERVFRSELMFRKRKHLIGKRLKVSLSITDLFAPTWKGFLSYLSWQKPVTAPLPDIEGQTNEGQIGLMKYLGLKNYPLTQYWSRPSLLFTSKIPTLTLYFLGSTKVVGNIILNGIKLSSWSSLKKLSVPVIVVGSLLGLTYLIHDLPRALPMNLSIKYKRKLQELDYIHLNAQRTSNEVRDVLRVPTREILRSCEIIMDKKQITKKELENKKESNLLSIKFFQSLYEGTVAQKLMVEEINLDID
The following text describes a protein:
Function:
Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (, PubMed:20926559, PubMed:27286456). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to its dimerization, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MGPQAAAGRMILLVVLMLSAKVGSGALTSTEDPEPPSVPVPTNVLIKSYNLNPVVCWEYQNMSQTPIFTVQVKVYSGSWTDSCTNISDHCCNIYEQIMYPDVSAWARVKAKVGQKESDYARSKEFLMCLKGKVGPPGLEIRRKKEEQLSVLVFHPEVVVNGESQGTMFGDGSTCYTFDYTVYVEHNRSGEILHTKHTVEKEECNETLCELNISVSTLDSRYCISVDGISSFWQVRTEKSKDVCIPPFHDDRKDSIWILVVAPLTVFTVVILVFAYWYTKKNSFKRKSIMLPKSLLSVVKSATLETKPESKYSLVTPHQPAVLESETVICEEPLSTVTAPDSPEAAEQEELSKETKALEAGGSTSAMTPDSPPTPTQRRSFSLLSSNQSGPCSLTAYHSRNGSDSGLVGSGSSISDLESLPNNNSETKMAEHDPPPVRKAPMASGYDKPHMLVDVLVDVGGKESLMGYRLTGEAQELS
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Sequence:
MSNDNESDEIPVNVVTENKDDEPKKESESLETVQENFSELLDAEKQKTSECEEKLKHILADFQNLTRKTQSDIQNGVNAKVDEFLLDFLKIYDDFIRARDVFSENKINTEGLDSILKNMDSLLKKYNVTAIDALGEIFDPNHHEAISVITDPDLDDNTITKEIRKGYISQNRVIRTTLVEISKKDDN
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Sequence:
MNFLLRTLAIAFVAINGIRASQCPSGFTYTDSIGDCRGNGQESGQLCYTTQTYTSDINTCINRAKRIYAQCYTSVQSGRPYCWPDAPGSTYNGGTSQPNQLGYQLPSPNSNPPPSQTIQQFSLSAASPTAQATSCQSEASGPINAIVNIQPDSGTPSASKISGFISFSQLSPSSKISITAKVVGIPAGQHGWHVHAKGNTYPNCSSAGPHWNPLGVDHGAPSAAVRHMGDFGNFNATDDGTFSVTITDSMATLYGPNSILGRALVLHAGVDDLGLTDNPLSKTTGNAGARLACGVIGYQ
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MPTPDTGSTGSGTGNKRRRTGRHSSTGVDVFQDGSEEEDDDDDPEEDPTPTMPEEDEEGDLRFYNPNQDPEKRRRLRATLRDHSRMVEENRDEMVKPNNLLLDALKKQDSIFGKVRQTADAALDSRFLVNASELAGKKLNSSLQGNAGVGIDLDQFVSKCIFFMKSGGHAADDEEAPAVPVPEDEDDAGDDGLDWALLGRQACFPCNKRPPTISFLLGPLSVEKREMKEGDMQQSENSNLSNLVKSINVRLRSHIEKVDEKVSEELSEIPDEEVQNEDVAAASRRHRAAVAPSQELAVSLLDFAINPHDFGQTVENLFYISFLVREGNAKIMKDEDGLPLLMPAKAHEMSDAREANIQKNQAVLSIDYTTWKMFIQAFDIKEPLIPHRENEEANVAPGGWYAG
The following text describes a protein:
Function:
Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.
Subcellular Localization:
Peroxisome.
Sequence:
MSGEKKEYPKEHIDLYQQIKWNGWGDTRKFLHQLKPSGTIAMTTPEVSSVPLPSLRGFIKKELTLPGEEDKPFVLDETPALQIENIHVDPPKQYPEFVRELKAFFLPDQLKDDKLARITHTFGKSLRDLIRVRIGQVKNAPDLIVLPHSHEEVERLVQLAHKYNVVIIPMGGGSNIVGAIEPVSNERFTVSIDMRRMNKVLWVDRREMTACIQVGIMGPELEKQLHKQGVSLGHDPDSFEFSTLGGWLATCSSGHQSDKYGDIEDMAVSFRTVTPTGTLELRNGARSGAGINYKHIILGSEGTLGIITEAVMKVHAVPQAVEYYGFLFPTFAHAVSALQQIRSSEVIPTMIRVYDPEETQLSFAWKPSKGAVSEFTSAMVKKYLHYIRSFDFKNVCLSIIGFEGPKKVVDFHRTSVFDILSKNAAFGLGSAPGKTWAEKRYDLPYIRDFLLDHNMWVDVAETTVSYANLQTLWKDAKQTFVKHFKDQGIPAWICAHISHTYTNGVCLYFIFASKQNENKDMAQYIEAKKLMTDIIFKYGGSLSHHHGVGYEHVPWMTRYATRGWINVYRSLKETIDPKDICNPRKLIPTIKEENNKEPFLFDVVNVKYPKL
The following text describes a protein:
Function:
Involved in the maturation of specific proteins in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MISKLFLFVLGLFGENGISPAELVISKGLDIDLGLDFLCVGGLTVSFVSIISKDHRNALVALLQWIFYLSIAQVGHVFLSYKWDSLLLEISFVAIFLAPFGLFGLHDDVKTSPRLQQRRSANQNRDGHHGSKRLLFWLVRWILFRLILAEALTGLDDIFGTGDGKFSFPEATQIATNADNLASVFPSVIFSSHSDRASLAEWLGDERFGHFAIEASAWCGLQMGGKTSQTDTAPLCEHHSKPEVKQSRDAHPSKVTTSSAEVVKDSKKEKKSNGISSTFRAILKVSAGFAVVAAILALYGLPAITQNGEDDNDELAGKAEKEDEENAHVSVVRVAKKYFCPMAGEVAWEGEITLNMWFGGLSIRYFSSKFQVPLTWYDGQTSGQYLPSELQETYLWSHKHYRLVNNYVTASKRVEINGSPIGRLEVIFEGSHSLKGSDWLEYSFKFKPGNVNVVPPFVAPHHPRLDETLHLASRDSYKEHHWILNLVYRLLTNQEEVLELLKESPFQDGPPRYMRASLYRYKFNNNDHNNDDEDGGDGGKENEDDDGGDGGGNVVGGDDKDDEERLSAIRSPKTAATTWWDRKWIGYYLPVLSIDDPKFSEYLKLSGIIRIEDRVGQRSKESNCKHSNVLGSFLSFVRSLLGQSDGGCLCLVLISLALLLAHVDLSSSSSFSSSSPSFSSSSSSLSSTPLATKRGKSPRPNQQCSNNGGVKTVDHDQHDQTDVINVPIHYVDKTRM
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MATSIEAAVESLREIKSKEPPMWLVPKQELSQAVRAASKHLFSSLKPHSPKSPFDQLLIEGFDAEQIWQQIDLQSQPLLYTLRREVKKFEKNPEEISKLKEAIEGGKKKKVVEEKGTDDIDDDDDDDDDLDMDDDDDYDDDEEEEEKKERGREEESEREGEEMELEGEEKGGIEDKFLKIKELQEYLEEDEAKEYGLKKNKKTKTETKKKEEDTEEEEEGEDEEEEEEEDDDNDEAEEEEDELGLFDGDDEDDEDSLENARYEDFFGTKKNKGPKEKAKSRDRFEGDSGSDDEQDFDKRKDGLSTHEEELKKLQSKIEQMEKANLDPKVWTMRGEVTAAQRQKNSALEVDLDFEHNVRPAPVITEEVTASLEDLIKTRISEGLFDDVQKSRSLSSKAPRETKELDDNKSKKGLAEVYEEEFVQKTDPAAAPLSFSDELKKEASMLFKKLCLKLDALSHFHFTPKPVVEDMSIQTNVPALAMEEIAPMAVSDAAMLAPEEVFAGKGDIKEEAELTRSERKRRRANKKRKFKAEAAKRLAKKPRETTQVDSNEGVRKTSDLLSLSVGGQQYVFKRGRQGRLGFISTSVLLFSLSRSFISKRNKYTKS