lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play a role in JNK activation.
Sequence:
MQVPQDGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALRPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPLRRSFSEDTLMDGPARIEPLRARKWSNSQPADLAHMGRSREDPAGMEASTMPISALPRTSSDPVLLKAPAPLGTVADSLRASDGQLQAKAPTKPPRTPSFELPDASERPPTYCELVPRVPSVQGTSPSQSCPEPEAPWWEAEEDEEEENRCFTRPQAEISFCPHDAPSCLLGPQNRPLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPHGHHLRLELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAAVMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVAPMVRLLEGEEVAGPLDESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPNPELREALTTGFVRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEPDR
The following text describes a protein:
Function:
Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Localizes to microtubules in interphase, associates with the mitotic spindle during mitosis, localizes to the central body during cytokinesis.
Sequence:
MSDEVFSTTLAYTKSPKVTKRTTFQDELIRAITARSARQRSSEYSDDFDSDEIVSLGDFSDTSADENSVNKKMNDFHISDDEEKNPSKLLFLKTNKSNGNITKDEPVCAIKNEEEMAPDGCEDIVVKSFSESQNKDEEFEKDKIKMKPKPRILSIKSTSSAENNSLDTDDHFKPSPRPRSMLKKKSHMEEKDGLEDKETALSEELELHSAPSSLPTPNGIQLEAEKKAFSENLDPEDSCLTSLASSSLKQILGDSFSPGSEGNASGKDPNEEITENHNSLKSDENKENSFSADHVTTAVEKSKESQVTADDLEEEKAKAELIMDDDRTVDPLLSKSQSILISTSATASSKKTIEDRNIKNKKSTNNRASSASARLMTSEFLKKSSSKRRTPSTTTSSHYLGTLKVLDQKPSQKQSIEPDRADNIRAAVYQEWLEKKNVYLHEMHRIKRIESENLRIQNEQKKAAKREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEEENAARKGEALQAFEKWKEKKMEYLKEKNRKEREYERAKKQKEEETVAEKKKDNLTAVEKWNEKKEAFFKQKEKEKINEKRKEELKRAEKKDKDKQAINEYEKWLENKEKQERIERKQKKRHSFLESEALPPWSPPSRTVFAKVF
The following text describes a protein:
Function:
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
Sequence:
MSRVVLEGLEFHAHHGVFAAEGVLGARFVVDAELHSPFAGIADDLGQAVNYAAAYAAIREEVTEKTHQLIEVLADRIADRLLSDFSRLERVKVRVHKPFAPLPGIFRDVYAEIEKERT
The following text describes a protein:
Function:
Major component of Woronin bodies, fungal-specific organelles that occlude septal pores in order to separate intact from damaged compartments. Hex-1 binds directly or indirectly to the Woronin body tether that in turn is anchored at the rim of the septal pore.
Subcellular Localization:
Cell septum. Note=Localizes at Woronin bodies, fungal-specific organelles that plug the septal pore in case of physical damage.
Sequence:
MGYYDDDAHGHVEADAAPRATTGTGTGSASQTVTIPCHHIRLGDILILQGRPCQVIRISTSAATGQHRYLGVDLFTKQLHEESSFVSNPAPSVVVQTMLGPVFKQYRVLDMQDGSIVAMTETGDVKQNLPVIDQSSLWNRLQKAFESGRGSVRVLVVSDHGREMAVDMKVVHGSRL
The following text describes a protein:
Function:
Transcription activator that regulates root development; promotes the production of stele cells in roots. Coordinately controls the number of all vascular cell types by regulating the size of the pool of cells from which they arise.
Subcellular Localization:
Nucleus.
Sequence:
MGVLLREALRSMCVNNQWSYAVFWKIGCQNSSLLIWEECYNETESSSNPRRLCGLGVDTQGNEKVQLLTNRMMLNNRIILVGEGLVGRAAFTGHHQWILANSFNRDVHPPEVINEMLLQFSAGIQTVAVFPVVPHGVVQLGSSLPIMENLGFVNDVKGLILQLGCVPGALLSENYRTYEPAADFIGVPVSRIIPSQGHKILQSSAFVAETSKQHFNSTGSSDHQMVEESPCNLVDEHEGGWQSTTGFLTAGEVAVPSNPDAWLNQNFSCMSNVDAAEQQQIPCEDISSKRSLGSDDLFDMLGLDDKNKGCDNSWGVSQMRTEVLTRELSDFRIIQEMDPEFGSSGYELSGTDHLLDAVVSGACSSTKQISDETSESCKTTLTKVSNSSVTTPSHSSPQGSQLFEKKHGQPLGPSSVYGSQISSWVEQAHSLKREGSPRMVNKNETAKPANNRKRLKPGENPRPRPKDRQMIQDRVKELREIIPNGAKCSIDALLERTIKHMLFLQNVSKHSDKLKQTGESKIMKEDGGGATWAFEVGSKSMVCPIVVEDINPPRIFQVEMLCEQRGFFLEIADWIRSLGLTILKGVIETRVDKIWARFTVEASRDVTRMEIFMQLVNILEQTMKCGGNSKTILDGIKATMPLPVTGGCSM
The following text describes a protein:
Function:
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the rad21 subunit of the cohesin complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Associates with chromatin. Cohesin complex mainly associates with broad centromere region. Also associates with mating-type heterochromatic region.
Sequence:
MSESVTTGSDDDGGDRESSPVMLSQSFDPMSSSSNSSSEENSDDDYEKTISSKKRHPRPNSKGVNVKRSRRNAIVEEDPQEEIFNNLFAFLLDQKVDTMDIAVSWFADYAKDNQSALANLINFILKCCGCNRAINVFDVQDQDSASATLSQIQLSVERTSTRDYPLNSKNLKFRNFRKRLTGLLSNFVSQLSIRNYLYNSTVFEDIMSWVVAMSSSTMRPIRHTATVFCLNIMTFLCEKSKELLNEHAIATKQLEKEEKRSRVNRNRINELNNSLGEIVKQQDTLTTYLNDYFDSVFVHRYRDVEPKIRVDCLQELGVWINTVPSIFFSGSYLRYLGWMLSDINTTVRLTVVKVLRKFFETDSFIGGLRHFSSRFKERILEMSCVDADIGVRVASIRLCNAMRTCGFLENSEILKVLKLILDINPRVQREAVLFLCKVVDESVNEKIDLWGEEDYILKAFSQTSLTTFSVHWIKFSQMCKLLEEVRLSYQSSFDYDTLLRIFQKNGNFITPITQALLNACEIDSIYQSWEDISNFVLFDNYTSTLKDPIDSILSFCKLNDFQESILLQLLSASIQTVCNNNFITPKTVHNKQAAETTNDQNKDKDLLYLNLLPYINSITERNSASPTLLHDSLRLLFSMDLTEMTDPQLSRHFELLINNLKKFFLTNNDLQIIQGCTILFLRLDSIPALKEDLKLLVTDICDQTVTEFLKNFGSFNIQDAVITKDEFVIFEACLTRIEGCTSLKDFSDYPEFDIIYERLVSLLSRVPNSYEDTLKFSAINTLQSLLFWFFLRKDNPADEEKKKDDETKVFNCLINIMNNDSSKILQLQAARTFLETVIMKEGVKASHYNDDNRVSEEHNFLKPQFLDALLKILEGWLYTYAKVGQFPFKRLTQASSPHTQISLDKNPLNRRLLEHVCCDLTSKLLIVVSLSNTITPEFSQQFCELRGHYGPKLSAIVDEFLN
The following text describes a protein:
Function:
Subunit j, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain. Minor subunit required to maintain the ATP synthase population in the mitochondria (By similarity).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MFQTLIQKVWVPMKPYYTQVYQEIWVGVGLMSLIVYKIRSADKRSKALKGPAPAHGHH
The following text describes a protein:
Function:
May play a role in spermatogenesis.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome lumen. Note=Localizes to the inner and outer membranes as well as to the matrix of the acrosome.
Sequence:
MENLPSLLESIYTTWLSLSSTIWAMDMILAFVCGLGLYLLLLPFLESHLSSSPSDINFTRKPQIQMTWQSQYMKKFRNHCRNDAKAWEECLKKLKEKEKDELFLEEMSPGHHLNSLGNMFNSASAKQDSTTLSPFWNLKEKSEEQMATQKLSYPKISGDHLQEKYDQLYWGLPSLHSESLVAAAWIPQTTSTLPSPFFLFNVISSVYPIHLQDKMSPVLPHTHPLSYLDLQPPPLILSPLEFQSPALNQVHFQSPLPVLLPSSLPYSRDSGACYSQSQSKPHCPTTEIQYRERPLVTKQLESRLTLPLMVQKDAYSILASNPSHDWAVPIFPDNFPISCELRDKLEQHIQKWFIQHQWYFPPEIQESEEVMGLQNSVTGNYQIRDQPCTSQAHMSTGEHNKQGQKVKFQLENESCKNLGPILGKGPKDPVKGLEKNVVKVQGANILEPERNLVKHFKSDSRNDSSNYIDEDLENNWKANFGTKSGQINQGLTPLSMRQSWLAMNDSFCDTDIHMETRNLTAIKSSEKFMCSREKLAFLNPETRQTLEEHVVRFWVKHRWGLPLKMLKPINLFKLKSTESLPLTLCTQPSSTNSVHRTNSAVEVVRFLGKPCLRQIIIKDSSPPPGNLLLVSSPSCKRAAIRRPPSGVDHEPSVALPNKPQSAYLAETLAYNFMETPTQSGGVLKDEMETEEVLLLPRMTCAPNLRAHNPQAKVVSEYPYNVETELTGQPQIYTTSVLLPKHSRSMPLPVDTLTSNALGDIVMVDGGNGLVQQRPSTPKHQVSQKGQIKMLVPTYQGEDTKRQSERKYEDMSKFSPVTERKNNFENQYYQTLPKTTQVLPESLFQRLLSRFLPRVHPKKTIKGQECHPQKDNPTAATAQNQRRQVRKQPYMDDNVTEAQKLMTTVGQMLEKKMMQHQHHASKVNQPRVVPPGPTSWFSHGHMPVSCLKRRRPPSYPANSLCQRRYIQGRHNRGQLPQKSVQFSQKPQILRNPRHMYPKSALNVVNSSQNRTTVPRTPNQHLCCPRHCAFQRNVCRELGHPSVAFPNRKT
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (By similarity). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MFIEVEKFVEARTNSIAQLLKAIDNDALVSGEVTKGPRTAAQRLPRHMRRRAMAYDIRRFPRTMREFAAAHLISKHAKKCPSRFARRKSANSRTKFGRSTSTKGIWLSTHVWHAKRFRMIQKWGFKLADRSFQRGFRAVLRDSNKNCVIRDRSYYTCVTIQCTDAYSKISQFSQKGCRGQSSRDEEEECHQLYMPGKYPFGYIGPARFQRLSGDKVHIWIHPSSKLQFMKALLEYYNLEKQENTEEDLYKNSEIKVSIDAENICRFHLSGPKCLSKLRDSIRFVNDEKFSSEHNYFLSVSDSVFQSSRDGEVINLLIEDPRTTWDRKTVLKHKKVNKEADNERIRVSKFWNKEFREMAIEKRMADSEFHKQNSSKINGVISTEAKVPIILIIRNEGLKALDGADILIPEPFAKDFWVSLQRRGVRASGLRDEYAAHLESKALYYPLDDVGSEAGRESELAMKKELIEKYLGKPHNRRCKHWSAVSVKYPFEFKWDELSQDWNLSNKPRSEAFVCRDLQKLRIIEEAMKKGSGLEEFQEPGMLIPVKLQFFGRGRPKKYGMVCLPTDDDLISIRKNRNREIIQTPPEASSQDSDIVEAMEIEEITVKKNQGFMSLEAAASEKPINLKLLFEETTKLDDKTTKRKRVNRKKRESKKRRKIEQEKRKEEAEVEEVQKLATKYRFSANREIIGRLVAGEQSVLAGHGVGIGYICANTLSLIASNYHKSKTVVMVRNSTSKYYHPAYVTILKNATKI
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase.
Subcellular Localization:
Nucleus.
Sequence:
MKTELQMAKHTHNDEDDNENVVRKKMKLLPDDEKLVAFQDWMRQEGFLLFNVSVSKRNVASGWGLVADKDITEGDVLFTVPRSVLLHPCTVSDELKVAIEAAGEELDSGSSWVPLLLCLLHEYDKMEAAACGFGGRWQPYFNMVPDFDDLHLPMMWSKEELNEELKGTNLLGLLDRDLKSLTFEFEHIVVPFVKKHPQLFNADNITLHHFKKMVSFVMAYSFTEPKKPGKDDDDDDDDDEDDVHPPMMVPLADILNHASENNAFIRFRPQCLEMLAKRNIKKNEEIFNTYGELSNEQLLHMYGYAEHPTLALYDTVDIPLNDLRETFLQMNTDQPTQQQQQQQQRHQSTNLPVANQNAPFIDKKWSYLTKLGYIADDGCLVLSHDGVLTEKMMNSIMKNMSKLPDSYKMLLNKLATRQLGKYGRSLEEEEELMKKLEEEMEKNNFQPTQQAEHSSTSPDGGCTQLECTNVPTNMKHHLRTKLYSSYVRCGQMRLLQKLTSSTLGGFS
The following text describes a protein:
Function:
Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQLSFGLLGQQRAGAIYLFIYFLIDGCSPRHRLAMATVEVLPGLYLGPAGRGKAAERPPGITALLSVDSEPPGEVGLEDVLHLEALDQPGCDLLSRLDQAAAFIDRIRAKEGAILVQCHAGVSRSVAVVTAYLMKANNLPFEEAYTFIRAIKPDAKMNEGFEWQLKLYEKMGCEVDVTSAVYKQYNLQSLTERYSESQDLPKEIFAIDPNNIEQATNCELTYKCRKCRRLLFQSSNILPHDEGTGLAAFAHKRFSEPAPFHCNSRPGCTSYFIEPLQWMEPMLLGVIEGQLLCPKCTSKLGSFHWHGEQCSCGRWVTPAFQIHKSRVDEAKGLPAGALLSARKQS
The following text describes a protein:
Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MMINLEARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDT
The following text describes a protein:
Function:
Functions in the RNA-directed DNA methylation (RdDM) pathway. Acts as a pre-mRNA splicing factor, likely by affecting Pol V transcripts. Affects DNA methylation of transposable elements (TEs) and preferentially influences NRPD1- and ROS1-targeted loci.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MDKERYSRSHRDDRDRDSSPDHSPQREGGRRRDRDVDSKRRDSDHYRSSRRGDREDERDRTKDRRGRSVERGEREGSRDREKHHHERSHEGSKEKESRSKRKDREEENGARDGKKKSRFADGNGERRSRFEDVAIEVENKDAQVSEGSGATNPTSGVTMGASTYSSIPSEASAAPSQTLLTKVSSISTTDENKASVVRSHEVPGKSSTDGRPLSTAGKSSANLPLDSSALAAKARKALQLQKGLADRLKNLPLLKKATKPTSEGSPHTRVPPSTTTPAVSTGTSFASTLPHTGLAGFGSIANIEAVKRAQELAANMGFHQDREFAPVINLFPGQAPSDMTVAQRPEKPPVLRVDALGREIDEHGNVISVTKPSNLSTLKVNINKKKKDAFQILKPQLEADLKENPYFDTRMGIDEKKILRPKRMSFQFVEEGKWTRDAENLKFKSHFGEAKAKELKVKQAQLAKANDDINPNLIEVSERVPRKEKPKEPIPDVEWWDANVLTNGEYGEITDGTITESHLKIEKLTHYIEHPRPIEPPAEAAPPPPQPLKLTKKEQKKLRTQRRLAKEKEKQEMIRQGLLEPPKAKVKMSNLMKVLGSEATQDPTKLEKEIRTAAAEREQAHTDRNAARKLTPAEKREKKERKLFDDPTTVETIVSVYKIKKLSHPKTRFKVEMNARENRLTGCSVMTDEMSVVVVEGKSKAIKRYGKLMMKRINWEEAERKEGNEDEEEEVNGGNKCWLVWQGSIGKPSFHRFHVHECVTESTAKKVFMDAGVVHYWDLAVNYSDD
The following text describes a protein:
Function:
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.
Sequence:
MTVYGSARESKIYILVTTVFLYAGGTLSQKVQVHFHGATVLSWKVAGKDVLFQSREAIYDNQAPIRAGIPIAFPHFGQWEAGPTHGFARTSRWKLEEGPQKDSNGNATVVYSLVDTEETRRLWNHKFKLTYTLVFGDTAFKTTLNGRAADLRTTSAGTAGTVARERLGLAPLTVTANCPYCGYRTEVTDLYKGHVEQICRLQYLSKILSRMALCFIKVKNTGDTTFNFTTLLHNYFRVDDISAVTVSGMQGLEYIDKTRNFERFTESRELLTVGEFVDSIYINTPSSHVITGINGGRTLRMDKENFPDTVVWNPWETMSPNFPDLGNDEYLSFICVEAGHVVNPVTLTPGEEFTAVQLLTL
The following text describes a protein:
Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK-signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Syd is required for efficient kinesin-I mediated axonal transport.
Subcellular Localization:
Cytoplasm.
Sequence:
MEGETLYGSEDSQSVMSERVQTLARNIYQEFQRMIQKYDEDVVKDLMPNIVNMLECLDLAYTANQEHEVELELLREDNEQLVTQYEREKQLRRTTDSKLLELEDVTEEENKGLQAKVESLESIVRMLELKAKNATDHVFRLEEKENEMRKEFTKVHDRYTELLKVHMDHVERTRGLLGTDRLEGAGLSSRQSGMQSWNLNIFILFHLKRSTGPLSFGFTSLENAVLTPGNSKFFSNPVADLASSINTTPSSLSQPNALQTEMDMHSELEMSGDVSGFEQNGTMDQSIIFVSINLSFNAYLKFISLVPGDVWEERSSNTLYQELSFQESSILEDSSEITGNWVHPGEFASSVTDNFYGMGKEVENLISENNELLATKNALNIVKDDLIAKVDELSSEQEILRDEIRSLHSMRTRLRLRTDELEAEVKALREEIENARKAAKSEEEEDVPLSQRKRFTRVEMARVLMERNQYKERWMELQEAVRWTEMLRAQKAAGQQEETDKRQKQSVWKFFSNLFNAGNEREPGQHPTTLLRQSQTVPSLQFHAQSGKVGPGSPVRFGSDPARPPRRKDNVLNSDRPDAPGVKAHVRRQDGRLQAYGWSLPSLSIASTTVGVPVPVYCRPLEDQEPGMKIWCAAGIDLTGGQTKDGGSMVGSSVFYNPLPGDSGPTALHIGDEISDDANKSDAIQTLAAELAESQWEREDAEMWERRLSSLVWIINSATGKSRVNVIDSNRPGDVILTFDIHAANVLCIATVAGVKDNDFGPPKETVPPTSSTDAKGADDDDDDNNIIIGDEEPTSMRSDGDGSSSKGDAIIGSIRFVSCSVAGSDPLDNPKENDEDFGPVSTALATVWMGCQCGRLYIHSAVLHWKKPLRVIKLPDAVLAIIHVRGRVLAALANGQVAIFARSATDGEWDLSAYWLLELAPPTVAVRCLTRVHSTVWAAFRNKIAVIDPESLRVETCFEAHPRKESQIRQLCWAGDGVWISIRLDSSIRLFHAHDFRHLQDVDVEPYVSKMLGTGKLGFSFVRITSMMISLQRLWMGTGNGVIISVPLSESSGASGKPVVIKDILSSLNHNHDPRDRVVAGSFIPYCSMAQAQLSFHGHKDAVKFFVAVPVAQPSEQGSTMSAPSPTSMLVLSGGEGYVDFRQGNQFHFHLNLKLSKTRAWGILSYTIS
The following text describes a protein:
Function:
Extracellular fibrinogen-binding protein that plays an important role in virulence. By interacting with the alpha chain of fibrinogen and its derivative fibrin, enhances a non-functional interaction between fibrinogen and platelets and is responsible for repression of fibrinogen-dependent platelet aggregation. In addition, assembles a fibrinogen protective shield around the bacteria which results in impaired phagocytic clearance by the host. Mechanistically, interacts with host complement C3b deposited on the surface of the bacterium via its C-terminal and then recruits fibrinogen via its N-terminal.
Subcellular Localization:
Secreted.
Sequence:
MKNKLIAKSLLTLAAIGITTTTIASTADASEGYGPREKKPVSINHNIVEYNDGTFKYQSRPKFNSTPKYIKFKHDYNILEFNDGTFEYGARPQFNKPAAKTDATIKKEQKLIQAQNLVREFEKTHTVSAHRKAQKAVNLVSFEYKVKKMVLQERIDNVLKQGLVK
The following text describes a protein:
Function:
Probable transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element.
Subcellular Localization:
Nucleus.
Sequence:
MGAQYSTELNKYNNNNNNNNNNNNNNNNNNNNHTISGNENLNNNNNNNNNNNNYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKNNGNSNSNSNNNNNNNGINKYSNYFESLINNTNKDTNIPNNSNSNNNNSDRDFIQNMIKSANQIKPGEKELVLFHKLHQSLKENQSFSIEELRNSSILSISPDKSFLTNINEINVNNNNNNNNNNNENNKVGVNGSSTTTTTTTTTTTNNNSNNNNNNNNNNNNNNNNNNNNNEDDEDDYGDDDTIENNEPTFVDKPNKSAKLQKPKLKSNLNDTNGGNSPQQNGKISKYMAKKLLALQQKQLEQEQEQKQQQKQQQQQQQQQQQQQQQQQQQQQKDAIENINNNNNNKLQPIVKNSVNKTTKQKKNKTTTHNVKQQITFLTKSDNEDEYDASDEYIDDDDDDDEKYDDDDDEYFEGNNNNNYKKNNISNKSKNKNNNDESDSFSESEIFKQKKLNHDKNQSNPKQQLTSHSEFDNSLLNKNQSRTNSKIQKLQIKEENYHQIQQEHGEKQQQQQQQQQQPQQQQQQQQQQQQQQQQEMQVDKEQTEKIINTNKKEEQKPNDYFPPIPTNPFKRDNETAFGKNNENNNNNNNNNNNNNNNNNNNNNNNNNNYRNNKPNGEGFLSNLKIIPPMISSSPYYSKKSSNVVPTSPKSNLSDQQPPFSPVQISPQKQSPATTTTTTTTTTPTPLKKQKKNKTNNNINNNNINNNNNNNNNNNNNNNNNNNNNNNNNNYSINNINNEEDEENNSTQNNNNNNNNNNNSPQNSNTNSNNSNNSNNSNNISNIVSDGYQWRKYGQKNVKGSLHPRHYYKCTFQGCNVRKQVERIGDTNQNSTVYKGEHCHGFPQTTRVVSDQQAFRNSVMFEGLDGNNNNNNNNNNNNNNYSSNSNSNGNGNGNGNGNGNGNGNGNGNSNGNQDQNGNSFNDQNGDSPTQHGQISPMNSPKNTIPTTTTTTTSISTYVNTNSTNKKNNSKQEKKISVKNETTDDDEFQEDIDQLSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDDNNNNNNNNNNNNNNNRFNGTSESKGSKKLVIETGSSIDHLDDGFFWRKYGQKSVKGSPFPKSYFKCAELTCPVKKQVIQQDSKYINTYRGKHNHDPPESEAIEKRKKHFNGLYNNNNNNNNNNNNNNNNNNNNNNINNINNNNINNLNSLNNINNINNNNNSNQINNFSGSIQNNLKNILKEQLKEAGKLHNEIENNLIDD
The following text describes a protein:
Function:
Transcriptional activator. Interacts with promoter regions for tbx-8.9, tbx-9, elt-1, hnd-1, scrt-1, and vab-7 genes. Binds the sequence ATTTATGAC. Binds to the enhancer region of the hlh-1 gene promoter during embryonic body wall muscle development. Activates the gene for mab-5 in embryo development. Necessary for vab-7 expression in C blastomeres in the posterior of embryos. Required for posterior V6 neuroectoblast cell fate specification during postembryonic neurogenesis (patterning) which generates the characteristic ray lineage during male tail development. Binds to ced-3 promoter and activated expression which is crucial for tail-spike cell death. Has a role in E cell specification in endoderm development and body wall muscle development.
Miscellaneous:
MISCELLANEOUS: Fifth intron is thought to contain a regulatory element required for expression in postembryonic neuroblast V6 cells. 3'-UTR thought to inhibit self-translation in anterior blastomeres.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Chromosome. Note=Localized to condensed chromosomes.
Sequence:
MSVDVKSDFSENESSSTPSPTTVPADVTWPHYPMMPFMQPHPLREKMLQPTFDPQIYGRWSQMGDTGFYGHPDLYPFGLPQLAANGQIPAVEAVDVKPPLSNGSSSSDSGMYPSPSDMMTPFPSTSSGAASSSELSAAAAAAANYQMRAATCYQQSVWPFMDYQQFQGFSWKMPLGNNHGKDRRSSSDGKTLPTGPGTNNVRVRTADKYRMVYSDYQRLELEKEFHTSPFITSDRKSQLSTMLSLTERQIKIWFQNRRAKDRRDKQKIRL
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion.
Sequence:
MMSSVRTGASMALRARPTAQIVPFRAAAVASISSSSRKDATGAVAPAGAQHGIARRERREVPLPSQEGTKGAVQYALTTLDSIVNWARQSSLWPMTFGLACCAVEMMHLSTPRYDQDRLGIIFRASPRQSDVMIVAGTLTNKMAPALRQVYDQMPDPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTSEALMYGIFQLQRKMRNTKITRMWYRK
The following text describes a protein:
Function:
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Subcellular Localization:
Cytoplasm.
Sequence:
MFNINFNFLKGLHQPAPRYTSYPTIVDWESSSDYGYTALERLAQEQDPLSLYFHIPFCQSMCLYCGCTVVLNRKAEIVDHYIETLIQEMRLAFSLLGGKKPVSRIHFGGGTPSRLSRAQFERLFTHIHRFFDLSNIEELAIEFDPRSLREDADKPLFLHNLGFNRVSLGIQDTQWEVQEAVRRRQSYEESLLAYQLFRDLKFTGINIDLIYGLPKQTQSSFKQTIEHILDMRPDRLALFSFAHVPWAKPHQKALRTKDLPSMEEKFAIYSQSRHTLIQEGYQAIGLDHFSLPDDPLTIALKNKTLIRNFQGYSLPPEEDLLGFGISATSFIRGIYLQNVKDLREYSETIQAGKLATVKGKILSQDDKTRKWVIHTLMCSFSLSKLEFEQRFHERFDRYFADSYDRLCGMESAGLIRQDSSSLQVTPLGELFVRVIATAFDHYFLKNIVEKPLFSKSI
The following text describes a protein:
Function:
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTPPPPPPPPPGPDPAVDSSTDPCPEPQSLVVLFGATAGALGPDLGSDETDLILLVWQVVEPRSRQVGTLHKSLVRAEAAALSPQCREASGLSADSLARAESLDKVLQQFSQLVSGDVALLGGGPYVLCTDGQQLLRQVLHPEASRKNLVLPDTFFSFYDLRREFHVQHPSTCSARDLTVGTMAQDLGLETDATEDDFGVWEVKTMVAVILHLLEGPNGHLFSKPEVVKQKYETGPCKADVVDNETVVRARGLPWQSSDQDVARFFKGLNIARGGVALCLNAQGRRNGEALIRFEDSEQRDLALQRHKHHMGVRYIEVYKATGEEFVKIAGGTSLEVARFLSREDQVILRLRGLPFSAGPADVLDFLGPECPVTGGVDGLLFVRHPDGRPTGDAFALFACEELAQAALRRHKGMLGKRYIELFRSTAAEVQQVLNRYAASPLLPTLTAPLLPIPFPLAGGTGRDCVRLRGLPYTATIEDILSFLGEAAADIRPHGVHMVLNQQGRPSGDAFIQMMSVERALAAAQRCHKKVMKERYVEVVPCSTEEMSRVLMGGSLSRSGLSPPPCKLPCLSPPTYATFQASPALIPTETTALYPSSALLPAARVPAAATPLAYYPGPATQLYMNYTAYYPSPPVSPTTVGYLTTPPTALASTPTSMLSQPGALVRMQGVPYTAGMKDLLSVFQAYQLAPDDYATLVPVGDPPRTVLQAPKEWVCL
The following text describes a protein:
Function:
O-methyltransferase that transfers a methyl group from S-adenosyl-L-methionine (SAM) to the carboxyl group of juvenile hormone acids to produce active juvenile hormones in the corpora allata, the last step during juvenile hormone biosynthesis. Also able to methylate farnesoate to methyl farnesoate.
Sequence:
MNQASLYQHANQVQRHDAKLILDEFASTMQWRSDGEDALLDVGSGSGNVLMDFVKPLLPIRGQLVGTDISSQMVHYASKHYQREERTRFQVLDIGCERLPEELSGRFDHVTSFYCLHWVQNLKGALGNIYNLLKPEGGDCLLAFLASNPVYEVYKILKTNDKWSTFMQDVENFISPLHYSLSPGEEFSQLLNDVGFVQHNVEIRNEVFVYEGVRTLKDNVKAICPFLERMPADLHEQFLDDFIDIVISMNLQQGENNEDQKFLSPYKLVVAYARKTPEFVNNVFLEPTHQNLVKGIN