lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.
Miscellaneous:
MISCELLANEOUS: The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.
Subcellular Localization:
Cytoplasm, myofibril. Cytoplasm, myofibril, sarcomere. Note=Thick filaments of the myofibrils.
Domain:
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2); The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. Four skip residues (Skip1-4) introduce discontinuities in the coiled-coil heptad repeats. The first three skip residues are structurally comparable and induce a unique local relaxation of the coiled-coil superhelical pitch and the fourth skip residue lies within a highly flexible molecular hinge that is necessary for myosin incorporation in the bare zone of sarcomeres.
Sequence:
NWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFLNHHMFVLEQEEYKKEGIEWTFIDLGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKPEAHFALIHYAGTVDYNILGWLQKNKDPLNETVVALYQKSSLKLLSNLFANYAGADAPVEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVIDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLSRMEYKKLLERRDSLLIIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKEEFARVKEALEKSEARRKELEEKTVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKKKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ
The following text describes a protein:
Function:
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (By similarity). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Nucleus envelope. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body. Localizes to the reforming nuclear envelope on chromatin disks during late anaphase (By similarity).
Domain:
The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.
Sequence:
MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVRIMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGGKKAEATASALADADADLEERLKNLRRD
The following text describes a protein:
Function:
This protein binds to 23S rRNA in the presence of protein L20.
Sequence:
MYAIIETGGKQIKVEAGQAIYIEKLDVEAGETVTFDKVLFVGGENVKVGSPVVEGATVTAKVEKQGRAKKIIVFKYKAKKNNRKKQGHRQPYTKLVVEAINA
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that regulates the degree of methylesterification of pectin in seed mucilage. May be involved in the recycling of pectin methylesterase enzymes in the endomembrane system of seed coat epidermal cells. Possesses E3 ubiquitin-protein ligase activity in vitro when associated with the E1 enzyme UBA1 and the E2 enzyme UBC8. May be involved in xylem development.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Domain:
The RING-type zinc finger domain is required for E3 ligase activity.
Sequence:
MKKREHLGLGFFEWQIILWLSIWLAISQQALGLRPIREKPRSWSDEWLFGRKQEAEVGPFSAWNITGTYRGTWKFLNSLNSSSKFQDFQKENGNSVVELVAVPTKITGVHYVQGVVVFHDVFDNEQNVGGAQINLEGVYIWPFRQLRLVANSGKESDSGQEDNNLLSNPYHLLGIFSSQVFQESPRDRLLKRKLSPVNEMEKHCNIEIAAQVSRVASSENNGDKNYYHMEGLMESPGVGDDGDCFSPLLLNATSVNVEVYYNKAVNYTLMVTFVSFLQVLLLIRQMEHGNTQSGAAKVSIVMIGQQAIMDAYLCLLHLTAGILVESLFNAFATAAFFKFVVFSIFEMRYLLAIWKATRPSNSGEGWETMRRELSFLYSRFYGILLGGILIMYQFHNYMQPILLLMYSFWIPQIVANVVRDSRKPLHPYYILGMTATRLAIPLYVFGCPHNFMRVEPNKVWCICLCTFMGLQAVILLLQHYFGSRCFVPRQMLPEKYNYHRRFNRDVSRTTDCVICMTAIDLRQHTSDCMVTPCEHFFHSGCLQRWMDIKMECPTCRRSLPPA
The following text describes a protein:
Function:
Not essential for cell viability, but required for efficient secretion of many proteins.
Miscellaneous:
MISCELLANEOUS: B.subtilis contains five chromosomal type I signal peptidases: SipS, SipT, SipU, SipV and SipW. They have different, but overlapping, substrate specificities and have different transcription patterns.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSMYPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYINGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGLFTKKQIAGTSKFVFYPFNEMRKTN
The following text describes a protein:
Function:
Probable mitochondrial mRNA stabilization factor.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MIVRGKCLGRSVSKAVSLFSRPISVISAKSFATTTNLLQNSKDDSTEATIPWYMREENSSPVEVLNKIEVPELPENSPQSLQEFVTLLTVEYGLTDLEIFDLSQLPEDHPKSLEEQNEENYVILASGKSEKHIYKAAYELRLYIKHTYKHLPIIEGMSSNSISKVTRRRLAKRVRRGPPATASTFGIGANSWVSCGTGVDGIVIHLLSRERRESLNLEQLYSDEQENEESHSTPEIDQDRLFFGDRRGFHTSSRNFNLNTLSNIYDSYVIDGNFDTSQKFKAQFDLNFKGGSVEEYNKKFELYRAINLVNANVVEANEIEQIIWDKYSSLDLALQQEIDWNTEIIKDTIKYMEFLVDLNARHSPREKLDKLSGFISNITCFAGDSIDLFTIDKFGALLWRLTWVSENNNALDSANLNEIIKRKGDFEPGTNTISFDNELGRNIRELLRQNKYSSNKETFPLWLREQMMYTFGQAGLWDRFWRDWQSILQSLNKTNERIYFWVVTALFLSKVDNRDALRHLFTKYWSNPSGASFVADYTTNNHQFNSDNERMALKSVLVQIGEKYNTSPWAREAAQFADNL
The following text describes a protein:
Function:
Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro. Does not use oxaloacetate or NAD or NADP as electron acceptors.
Miscellaneous:
MISCELLANEOUS: Present with 264000 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MTASLTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPRYISVPLGSINSMGLPNEGIDYYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNGITELNLSCPNVPGKPQVAYDFDLTKETLEKVFAFFKKPLGVKLPPYFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSIDQFRGKLNSI
The following text describes a protein:
Function:
Nucleotidyltransferase that catalyzes the formation of cyclic di-AMP (3',3'-c-di-AMP) from 2 molecules of ATP and plays a key role in innate immunity. Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses. Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 3',3'-c-di-AMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor.
Sequence:
MALDASSLTRKLHVFSAKYVKISEETTRRARRLVKDYIEGQIIAYITENSNIEIQKLEYTGSFYEGLKTENADEADIMVVLKTPGSGIEVVQSQVPGYVHLKARDAPMFSKYMSPKGYIKAKKLRNSWFQSYVRRAVNKIEPQPPHSEVRLVVRSHGPAVQVDIIRKGSEEMLLSVDLVPCFQVEDSWYVPKPFKGKRYLSRNELLWRKTFSPKEKQILASMDKDPNGQGGCRHELLRIVKTVVKKPVTSLPLDSYHLKAAFMHYNDRGDLDWVSEDALGKNFFGFLMELQIRMESRNLPNYWLDGINLLDDFKEDVVKQMANRLRRILNSEVRLNKILE
The following text describes a protein:
Function:
Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons. Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy. Lipid transfer protein required for lipid droplet degradation, including by lipophagy. Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown. May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis.
Subcellular Localization:
Cytoplasm. Lipid droplet. Midbody.
Sequence:
MQTPEPAEIRVIRENYDKALQCLNTGLQLDEAGNKDQALVLYRLGRRHLLSGLQVDTRGGRCTGRCWDSARQTQLKMGETLRTITARLGALESASNTGQRLYPTLPVFQDKNSQRAFNSRGASGRAPSRPVSPPVGFAVPNELPPAYTPQPTDGHLSLSHGANRAFPDAPHQGSRRQAVAPVNLREAGMEIMFLPSGVQMFFVSAEGRVTAPSYPGYLRIIIYSQDSDGSANTGYAPAYLQVCDWIYPLYPDFPVLLSNNGVFTFPDTTAAVPGSYVGVVLSSDLPAGERDLFQEQLSVLAQLRVQVDEEGGGATGADTNLSEKIPLSEASQTPEEKTAPVWSEKMSQSILAGSSWLGRGLVRGAEATGKAIQRGGTKLRDNITPEETPAEVSPKVTKGLNAAKQATGGAVKVSQFLVDGVAAVAGKVGKELAPHVKKHGCKLIPESLKKGKDGSSKMDGAKLVAGSSIQGLSTLWSSLETAGKTIGKSLSSETVTTVRHKFRGLGSILDPPSGV
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
MLWFGHIRSRDSDEAAKKMLRMRLPGKRSRGRPKRSRNPVLARGIRRYSWSAMFTSKAMYKRKTKTTETKVKIKKKIKIKERPRATVWKTVGGDKNGGTRVVKLRKMPRYYPTEDVPRKLKSHGKKPVCQHKRKLRRVVFLKQLSSVPLLDITGMKIPKTLNDAYFKKKKLRGPRQQEGEIFHTEKKKYQLTEQRKEIQKEVNSKLLPLIKKVPQLKEYLRSSFYLTNGVYPHKLVFLNGFPNLLLRGSTPFYLQNCLNPCYTVVRVNTRF
The following text describes a protein:
Function:
Has at least 2 separable functions; Holliday junction resolution with generation of monomeric chromosomes, and negative modulation of RecA activity. Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation. Partially inhibits the hydrolysis of dATP or rATP by RecA. Holliday junction resolution is stimulated by RuvB.
Subcellular Localization:
Cytoplasm.
Sequence:
MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNKYYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEAKETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKEKNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG
The following text describes a protein:
Function:
Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta. Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity); [Isoform A]: Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry. Induces phosphorylation of MAPT/tau.
Subcellular Localization:
[Isoform A]: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=In epithelial cells, diffusely expressed in the cytoplasm, particularly in peri-membrane cortical regions (By similarity). Concentrated at centrosomes during metaphase; [Isoform B]: Nucleus; [Isoform C]: Nucleus, nucleolus.
Sequence:
MARPVQLAPGSLALVLCRLEAQKAAGAAEEPGGRAVFRAFRRANARCFWNARLARAASRLAFQGWLRRGVLLVRAPPACLQVLRDAWRRRALRPPRGFRIRAVGDVFPVQMNPITQSQFVPLGEVLCCAISDMNTAQIVVTQESLLERLMKHYPGIAIPSEDILYTTLGTLIKERKIYHTGEGYFIVTPQTYFITNTTTQENKRMLPSDESRLMPASMTYLVSMESCAESAQENAAPISHCQSCQCFRDMHTQDVQEAPVAAEVTRKSHRGLGESVSWVQNGAVSVSAEHHICESTKPLPYTRDKEKGKKFGFSLLWRSLSRKEKPKTEHSSFSAQFPPEEWPVRDEDDLDNIPRDVEHEIIKRINPILTVDNLIKHTVLMQKYEEQKKYNSQGTSTDMLTIGHKYPSKEGVKKRQGLSAKPQGQGHSRRDRHKARNQGSEFQPGSIRLEKHPKLPATQPIPRIKSPNEMVGQKPLGEITTVLGSHLIYKKRISNPFQGLSHRGSTISKGHKIQKTSDLKPSQTGPKEKPFQKPRSLDSSRIFDGKAKEPYAEQPNDKMEAESIYINDPTVKPINDDFRGHLFSHPQQSMLQNDGKCCPFMESMLRYEVYGGENEVIPEVLRKSHSHFDKLGETKQTPHSLPSRGASFSDRTPSACRLVDNTIHQFQNLGLLDYPVGVNPLRQAARQDKDSEELLRKGFVQDAETTSLENEQLSNDDQALYQNEVEDDDGACSSLYLEEDDISENDDLRQMLPGHSQYSFTGGSQGNHLGKQKVIERSLTEYNSTMERVESQVLKRNECYKPTGLHATPGESQEPNLSAESCGLNSGAQFGFNYEEEPSVAKCVQASAPADERIFDYYSARKASFEAEVIQDTIGDTGKKPASWSQSPQNQEMRKHFPQKFQLFNTSHMPVLAQDVQYEHSHLEGTENHSMAGDSGIDSPRTQSLGSNNSVILDGLKRRQNFLQNVEGTKSSQPLTSNSLLPLTPVINV
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MAQTEKLQNIETGQHQHNISMSNNLPKELLQRFISGNHYNHRLNGEEGEDDDVELSLGLSLNGRFGVDPKAKKITRSSSIASDFINPTGENGSAFVVSNLESNYLPRTCSLPTETKEELRKRKEMQTLRRMEAKRKRTEKQKILKTVTDKTMGEEDKRENGTNGDHHQKEFLKSFNGFFGVGVEGLSAQAEAAPPLTHESQGTGSSGTTEFESQPLQGMNKYTESRSPVSVQSLSDYEQRSIIAPGLVLGEKSSFPAGVAMEKNGSNKLTVTENGTKEVVRDVLEDMPYVSAKGDGPNGKRIEGFLYQYRKGEEVTIVCVCHGSFLSPAEFVKHAGGGDDVEQPLKHIVVHPSPFF
The following text describes a protein:
Function:
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Subcellular Localization:
Nucleus.
Sequence:
MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRAGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGITRSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPPTLRPTRPLQTVPLWD
The following text describes a protein:
Function:
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDNQNFLYLSLGAYIGVSMRLEIVSIVGNFLRDQTIPIDIFDNFIGSFVIGFYNDRYKKRDFSSHLAISTGFCGCLTTFSSWIIGIIDLVNSEQWFNCIIHLFIGTTVAYSGFKLGQNAETEFKFPFHQKLIYLAFLKLIIFQVLFQRWSMIVTALLSPFGAILRCYLSKLNHKDFPFGTLMCNLFAVWIAEALLISKIHLDDDSNKIINSVLKGFCGSLSTVSTWIKEICTMQSIELRFSYYWISLFLSVYIGLVIFQNLS
The following text describes a protein:
Function:
Transcriptional activator involved in the positive regulation of abscisic acid (ABA) responsive genes. Acts as a positive factor of ABA-mediated responses. Involved in the transcriptional activation of ABA-inducible genes in response to dehydration and osmotic stresses. Plays a positive role in both stomatal closure and water loss under dehydration stress conditions. Acts synergistically with ABF2 to activate the dehydration stress-response factor RD29A transcription. Binds to the consensus core cis-acting elements 5'-CGTA-3' and 5'-CACG-3' at the RD29A promoter. Involved in hypocotyl graft union formation. Required for the auxin-mediated promotion of vascular tissue proliferation during hypocotyl graft attachment.
Subcellular Localization:
Nucleus.
Domain:
The NAC domain includes a DNA binding domain and a dimerization domain.
Sequence:
MGSSCLPPGFRFHPTDEELIEYYLKRKVEGLEIELEVIPVIDLYSFDPWELPDKSFLPNRDMEWYFFCSRDKKYPNGFRTNRGTKAGYWKATGKDRKITSRSSSIIGYRKTLVFYKGRAPLGDRSNWIMHEYRLCDDDTSQGSQNLKGAFVLCRVAMKNEIKTNTKIRKIPSEQTIGSGESSGLSSRVTSPSRDETMPFHSFANPVSTETDSSNIWISPEFILDSSKDYPQIQDVASQCFQQDFDFPIIGNQNMEFPASTSLDQNMDEFMQNGYWTNYGYDQTGLFGYSDFS
The following text describes a protein:
Function:
Chaperone. Required for the assembly of succinate dehydrogenase subunits. Ensures mitochondrial gene expression at elevated temperatures and prevents heat-aggregation of the ribosomal subunit VAR1.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MLRNCLRKLGNHQTKCSVKTLHTPIYRTKNLQVLRDTLSGIKLLEKIITSSSYNKTLIYEPKYKSKPQVVSSHDTMRLHNVMRELLDSLQVDEATNTRLQSNRPRKLGRVGLQLFMDCIQDNLTATSTSLTCSLLEHYFKYPEKEVTNGIKAGLRYIRDFLAKNKIIVKSQNDVDALVEQLTMSSSDSQSIKRVLKAINYELFSDDIVRVINGNKTYDEVDVSKGWKYPAGILDSNEAYLRSLELPTKKLVSIDKDMLVLMYDGTLRDANKILPTITYARKLRKSVLLIVNGDCTGDALTSVTINNNRNKRENNESRIVVLKYSKKANNDLAPQENLDFIKFLRLPCGYDSIYSPEYSPLVPSKMCADKYYGSIESIKATTGEAFLYNSIDAEAIPNKVPKSFLQNTVTLSIGGHNEIEIDRRRNAIDNCLNNVLCHGLAKGFIPGYGISLLKAIPGLNELKANEPNFMTKVGINAVLSAVILPSEVAFKNAYGYNYYEINSLIAGAINEKSFPMAKFSPNSEPVNTVKDGNLEPWSKMDSCLAGVETFIELLTSCNTIITCVYKKPERHKA
The following text describes a protein:
Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPRNRAFSEPEYSAEYSADCSVTLPSDPGQAVGRTHEVTVRSSGCCLCLPRFMRLTFAPDSLENLYQTYFRRQRHETLLVLVVFAALFDCYIIVMCTVLYTADKLASVAVASVGLAADVLLYLLCRYGLLPDRVTRRLVPYALWVLIAAQIFCYLGLNFARFHQPSDTVGWQAFFSFSFFLTLPLRLTPIVLITSVSCGVHTLVLGVTIAQQQQEDIQGAALGRQLLANMVIYVCAITVGVMSYYMADRKHRKAFLEARQSLEVKLNLEEQSQQQERLLLSILPKHIADEMLQDMKKEASQKEMQQFNTMYMYRHENVSILFADIVGFTQLSSSCSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAACSIMMGLAMVEMEAGGIPGRVHISQNTLECLHGEFDVEPGNGGDRCEYLKERGIETYLVVLPKGPVGKNGINGVKLSVTSSNGNSPLLINTTECNGSVHTACTTPEDPEELDTRVVNPSFPNPRRRLRLRDLAERVIDAQENEQELNKLLNEALLERETVQALKGKYTNRLSLRFTDPELETRFSVEKEKQSGAAFSCSCVVLLFTAVMEALIDPWLVANYVTLAVGEVLLLILTICSLAAIFPRVFPKRLVSFSTWIDHTRWARNTWAMAAIFIVTLADIVDMLSCRAPQTSTVESTAVPPVVTAIRGCAENPKYYSFIAVLALIATTMLVQVSHMVKLTLMLLITVATGAVNIYSWSQTFDLYDLTRFKEYRVNLVPSKYTMSVMIFIMMVSFYYFSRHVEKLARTLFLWKIEVHEQKEKVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASIPNFSDFYTEESINNGGIECLRFLNEIISDFDSLLDEPQFRCITKIKTIGSTYMAASGVTSDNNTNGYACMKKEEISDRERWQHLADLADFALAMKVTLMNINYQSFNNFMLRIGLNKGAVLAGVIGARKPHFDIWGNTVNVASRMESTGVMGNIQVVEDCYCILKDYGFRFVRRGPIFVKGKGELLTYFLKGREKQGSFINGSFVTLPHQVVDSS
The following text describes a protein:
Function:
Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner.
Subcellular Localization:
Nucleus.
Sequence:
MAANVGSMFQYWKRFDLRRLQKELNSVASELSARQEESEHSHKHLIELRREFKKNVPEEIREMVAPVLKSFQAEVVALSKRSQEAEAAFLSVYKQLIEAPDPVPVFEAARSLDDRLQPPSFDPSGQPRRDLHTSWKRNPELLSPKEQREGTSPAGPTLTEGSRLPGIPGKALLTETLLQRNEAEKQKGLQEVQITLAARLGEAEEKIKVLHSALKATQAELLELRRKYDEEAASKADEVGLIMTNLEKANQRAEAAQREVESLREQLASVNSSIRLACCSPQGPSGDKVNFTLCSGPRLEAALASKDREILRLLKDVQHLQSSLQELEEASANQIADLERQLTAKSEAIEKLEEKLQAQSDYEEIKTELSILKAMKLASSTCSLPQGMAKPEDSLLIAKEAFFPTQKFLLEKPSLLASPEEDPSEDDSIKDSLGTEQSYPSPQQLPPPPGPEDPLSPSPGQPLLGPSLGPDGTRTFSLSPFPSLASGERLMMPPAAFKGEAGGLLVFPPAFYGAKPPTAPATPAPGPEPLGGPEPADGGGGGAAGPGAEEEQLDTAEIAFQVKEQLLKHNIGQRVFGHYVLGLSQGSVSEILARPKPWRKLTVKGKEPFIKMKQFLSDEQNVLALRTIQVRQRGSITPRIRTPETGSDDAIKSILEQAKKEIESQKGGEPKTSVAPLSIANGTTPASTSEDAIKSILEQARREMQAQQQALLEMEVAPRGRSVPPSPPERPSLATASQNGAPALVKQEEGSGGPAQAPLPVLSPAAFVQSIIRKVKSEIGDAGYFDHHWASDRGLLSRPYASVSPSLSSSSSSGYSGQPNGRAWPRGDEAPVPPEDEAAAGAEDEPPRTGELKAEGATAEAGARLPYYPAYVPRTLKPTVPPLTPEQYELYMYREVDTLELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLSDQLGQAVGQQPGASQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQPEGRSSSSLSGKMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHNVEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQLNLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENSTPLTTQDKAQVRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAPGPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASESSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERAANREEALEWEF
The following text describes a protein:
Function:
Involved in endosome-to-Golgi retrograde transport as part of the vps34 PI3-kinase complex II. Mediates the interaction between atg6 and the pik3-ppk19 core complex, leading to the recruitment of atg6 to the membrane (By similarity).
Subcellular Localization:
Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Sequence:
MSLELPGNYRLSRLKSIQIRNVQEIQNHSKFAINTTENLWKRDVQLKRAISEGTIRIFISLHVQSKKLPVYITETSGNANHIFYVDEKVTEKLQKYRHEEYFIVRTWCSSSSHAFKLHKEWKILRYDSNFRYIGNDPVFAVCHIRNGLLCEFNDGVYIYTTSQSSDIMRQTSFPKSASTYSIDRRKDGYTIQKITRILKLAECIDEMHIAKHEIRAHFQEEEFQQIRLMHKRMLLRDEKIDELAKLEHLWQKQINSITQMRTKFDKTKSWLSSKRNTLNKSKESLQKDEAEYVELANSLKTKVETNIEIRILMAHAIRMHVSHLSKIYPIQPSPGNHDEFTIRNLRLSFEPDKINNVEMAASIGFLAHLLQTLSKYLEKELAYPILCASSRSSILDTLTPDIPTRIFPLYPATRPIELFEHAIYLLNQDVNDFLETFGLPIDQSMDILRNFKKLLQFILSGQHLSFVQVTSTAP
The following text describes a protein:
Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQRDEDSHSTSGGHSNVLEQEIGLASQAFDEFSKSNYEQSVNLLSKLLTLKGSDKKIFLNMAVAEYYKSGQTKVNQLQTSLQDIVKKIQMENSNSAADFAEHCVIYYNLAVTYYNTKQYSQAVQCFKQLESLGENMDETLLMKIIYLLVDAYLSSFKPYKAFEVIEFFESSDKLNKANKQTLIMKQYKMKCHLMMRSLDGFSKEIKHLGDATKLQSKEGIFLKSQFEMLLRRYSQSVKTLSSHQGNDTRNKYYLMCCANNIAVNYFEMKKYNLAHKYLVKAVEHKNALTELQKKNGPSSENLSNNRHYELLYNMGVTLLQCNKPLLAFDCLLGVIQSLERDSYSEKTSVINCFVGSSTHKKAILGQGVNCKNFNNSKDSSAMPMPTMGFASLCLENALLCLNSTNSNVDKSKMKKKKKEDDVMDADGSDVDYLPDDLAAESIGSNELFIAMAPSSPVKINEINNLRCSILTLKCYIALHHKNYLIALRVSNLLLQQPNLSGIHRYLALMYKAEALVGLDRLPESTDLMLTDISDINIFSSSDAAYIQRRDDENINKCEQNTEKLQNVNWFPHTKEGAQCIMHYNVAVVSVINGDLVKARTFLQKSLQHLKQPYPTQVYYLMIYLEVAEAKGKSKDPPNIRSIVA
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MVNLLQIVRDHWVHVLVPMGFVIGCYLDKKSDEQLTAFRNKSMLFKRGLQPNEEVTWK
The following text describes a protein:
Function:
L-ornithine aminotransferase involved in L-proline biosynthesis. Also shows high activity toward L-lysine. 2-oxoglutarate is the best amino acceptor, but 2-oxoadipate also leads to moderate activity.
Sequence:
MVVRPNVKELPGPKAKEVIERNFKYLAMTTQDPENLPIVIERGEGIRVYDVDGNVFYDFASGVGVINVGHSHPRVVEAIKKQAEKFTHYSLTDFFYENAIILAEKLIELAPGDIERKVVYGNSGAEANEAAMKLVKYGTGRKQFLAFYHAFHGRTQAVLSLTASKWVQQDGFFPTMPGVTHIPYPNPYRNTWGIDGYEEPDELTNRVLDFIEEYVFRHVPPHEIGAIFFEPIQGEGGYVVPPKGFFKALKKFADEYGILLADDEVQMGIGRTGKFWAIEHFGVEPDLIQFGKAIGGGLPLAGVIHRADITFDKPGRHATTFGGNPVAIAAGIEVVEIVKELLPHVQEVGDYLHKYLEEFKEKYEVIGDARGLGLAQAVEIVKSKETKEKYPELRDRIVKESAKRGLVLLGCGDNSIRFIPPLIVTKEEIDVAMEIFEEALKAALK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAMAEAAPAPAPAFLTFDDVAVYFSEQEWGNLEKWQKEIYKHVMRTNYETLVSLDHAIPKPDLISWIEQGKEPFIKDQMDLEEREIVVICGDDREYNLENTKGWQFFELSPPLVKADDFPPIRQEVEPFILEQQNLEERAIPTYPISEIQGAINTKEEFHLDEPQSQDMLEVLPRKQGNLCSRLGQRTTLRYLHSKNKKPVFLKAYSIKRSFLRTKTLNHKIASPLGCQKVPLRQRFLYCSVSNKNFHGKVPLTHHEKSQLKDQLCQCSEYKKALSRKSDLKQSQSLQGQHHSLEKSSCWKWSSSAHQLFYKAKRPSQGPKGNRSFCCKGNLEGLQHIPSWGNLLHKERAKSFCFGTYLPTHHSLHSREKPFSCSECGKIFTFQAILTTHMRIHSGEKPFNCPRCHKSFYRKTSLKFHQNLHDEQMPFSGSECGKWFSCQSSFTDYSSVHATAKPFPCPKCDRKFCSKRSLKTHLRLHSGENPYPCGECDKTFTHQSKLTEHFRVHSGEKPFQCPECDKSFSQKSSVKIHQRLHTGEKPFSCSECGKCFNKQNNLNQHLTLHTGEKPFQCPECDQSFRLKINLKVHLIQHSGEKPFSCSECSKSFTQKFLLSKHLRIHNRERLFSCGECGKNFTHQSKLTRHVRVHSEKKPFSCSECGKTYSYQSQLTVHIRIHSGEKPFFCGECGKSFIQRSHLTSHIRVHKGKKPFSCGECGKSFMEQSELTKHIIVHSREKPFSCRECGRTYKHQFQLTEHIKVHNREKSFLCPECKKSFCHKRALKVHQQVHIRDRPFSCNECGRRFTYKGALNTHLTVHTRERFNNSNSDKVPGNISPLDNYWG