lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny.
Subcellular Localization:
Nucleus.
Sequence:
MVSLPPPQSDVTLPGPTRLEGERQGDLMQAPGLPGSPAPQSKHAGFSCSSFVSDGPPERTPSLPPHSPRIASPGPEQVQGHCPAGPGPGPFRLSPSDKYPGFGFEEAAASSPGRFLKGSHAPFHPYKRPFHEDVFPEAETTLALKGHSFKTPGPLEAFEEIPVDVAEAEAFLPGFSAEAWCNGLPYPSQEHGPQVLGSEVKVKPPVLESGAGMFCYQPPLQHMYCSSQPPFHQYSPGGGSYPIPYLGSSHYQYQRMAPQASTDGHQPLFPKPIYSYSILIFMALKNSKTGSLPVSEIYNFMTEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKSGSSSRKGCLWALNPAKIDKMQEELQKWKRKDPIAVRKSMAKPEELDSLIGDKREKLGSPLLGCPPPGLSGSGPIRPLAPPAGLSPPLHSLHPAPGPIPGKNPLQDLLMGHTPSCYGQTYLHLSPGLAPPGPPQPLFPQPDGHLELRAQPGTPQDSPLPAHTPPSHSAKLLAEPSPARTMHDTLLPDGDLGTDLDAINPSLTDFDFQGNLWEQLKDDSLALDPLVLVTSSPTSSSMPPPQPPPHCFPPGPCLTETGSGAGDLAAPGSGGSGALGDLHLTTLYSAFMELEPTPPTAPAGPSVYLSPSSKPVALA
The following text describes a protein:
Function:
Functions redundandly with IBH1/BHLH158 in a regulation node known as the incoherent feed-forward loop (FFL). Acts as transcriptional repressor that negatively regulates cell and organ elongation in response to gibberellin (GA) and brassinosteroid (BR) signaling.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing IBL1 are dwarf with round-shaped, dark-green leaves and short petioles.
Subcellular Localization:
Nucleus.
Sequence:
MQPTSSMNEEFLKKWQMGLQIFRPSIDNTSVHERKKAIKLSADVAMASLRKGTTCWSRALIEKTATEDNFLVRQMLSGIKAETLINKKLPKKTVCHRKIVRRSKKILRRKSKSASEEAAAKAKRLVKRRTQGLRNVVPGGELMSNDVLLLQETLDYIVSLQTQVNVMRSIVDAAEAEIER
The following text describes a protein:
Function:
Required for normal Golgi morphology and function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MHDPVKKSAHLTAGSTSTAEKLCFDKNEFMKANFSVDEFLHKNRNAPSLEQLRDNLGLYLKGLRAAMIDLINEDYADFVNLSANLVGLDQNIKTIQQPLEQFRSDIESIHGLIDENVTELRAQLEEKRQLREFKRGLQSLKKVYETINKLQDLIDRKLSGEQPIKAVDLERAALDLIQLKFHEKHCFKHLSPDHQGKIQQLEEQLHQHLRRFFNDALSQARNSAPESLERCLRIYITLNACDQAECAFREDVVAPYMTGVIGEQQLQNSPQGLAGIYSKILNFISLHMTDLLRLTLYSDKFPGFNFVVNSYWSDVETRLELHMNSIFAPGNSEVFYVKYKCTRDFLGKIEELLTCSGEQAVTFYRQHKQTKSFEARWNLPVYFQICFQEIAGKFEAQLEPVLQEDSLKDNLTDSDYKISAFNAAKEAMTRCWAEGVYLPEVFPKFYKLNVQVVLRLSRWITDAITQSKGSNFSKPYTRNQLLIALHADIRKLDAHLPELQQLIIKSVPVEQCTKIFSDVLAKSMSCLADTLGAHLTNIQKTLVELLIGECETENVRQVNDLPRLYRKTNREVPTRCSSYVEQMLRPLKAFAQQNESQLGTLVVEQILAEVASHITKAYFNVVSDVLTSVQKTEESLRRLRNVKSGGAATVSTGSSAVMSDDDKIRVQLRVDVTSWRQELCKLNFQATQIDKLVELTNMVEDSIKLKDNSA
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPEITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGKDGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNADLAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNSALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS
The following text describes a protein:
Function:
Involved in the biosynthesis of the nonproteinogenic amino acid monomer (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of vancomycin and teicoplanin antibiotics. Catalyzes the syn-addition of a water molecule across the double bond of a trans-2-enoyl-CoA thioester, resulting in the formation of a beta-hydroxyacyl-CoA thioester. Physiologically, DpgD could act as a dehydratase, facilitating the aromatization of the DPA-S-DgpA or DPA-S-CoA intermediate. It can use the non physiological substrates crotonyl-CoA and beta-methylcrotonyl-CoA.
Sequence:
MSETRVRYEKKDHVAYVTMDRPAVLNAMDRRMHEELAGIWDDVEADDDVRAVVLTGAGDRAFSVGQDLKERARLNESGVAPTTFGSGGQAGHPRLTDRFTLSKPVVARVRGYALGGGFELVLACDIVIAAEDAVFALPEVRLGLIAGAGGVFRLPRQLPQKVAMGYLLTGRRMDAATALRHGLVNEVVPAAELDQCVADWTDSLVRAAPLSVRAIKEAALRSVDLPLEEAFTTSYHWEERRRRSADAIEGVRAFAEKRDPIWTGQ
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLGKYGEASSGSMKNLENGLRDRVLYHQNMLSMNLTTEFYHTPFLTAGSGSNVETAAIVVGAPALAQSQKMLNSLASPSGLASSSSSSTSQQHATNGAAPSQTVPNSVSAAQQYQCQLCQKCFISSALLVQHMKTHDNNGFIAGRETAGSYGQQQQQQQQSVSSASSPVTAVASSSKTSPPVATQHIIKSEYIGGTVTNQYAYGMAKQFECHICHKSFMTMVNLNLHMKIHESAIKPLAATHMYAGQAGLAGNLIAGSTAGYHHGGQHHSQLSQHLAVQSASGSADGLCQICHKTFSTADQFAAHMKIHENEFKNRALYHSGSANDGGEGAPAPTSNGAGVGDHFYTASQPPHHHLGHAPPHLDASKGHRCPICHKMSNNIIEHIKQHEGQLQGTSDGSGAGYHPTNDDSQSSLEEDSDGGGGGGAGGDENLRKHECLICHKKFSSSGNLAIHIREHSGEKPFRCSVCGKGFIQSNNLATHMKTHTGEKPYACTICGKNFSQSNNLKTHIRTHTGEKPYACTICGKRFNQKNNLTTHMRTHQLVCMVCGVQFMHPIDLATHMKFHNDEKPYICSVCNKVYLNLDELTEHMKKTHNQVKPYRCHICDKTFTQSNNLKTHIKTHIFQDPYKCQVCSRSFQKEDDFSQHMLVHTADKPYECTYCGKRFIQSNNLKTHVRTHTGEKPYRCTICAKHFNQKNNLNTHMRIHTGEKPFECTICDKRFNQSNNLNKHIKTHGQEKDQQQQQVQQQQQQQQQQQNQQQQQQVQQQQQQQQQQHAS
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This may be a 5' to 3' ssDNA exonuclease (By similarity).
Sequence:
MAPSDTPPSAEDLPSQGELALFAPPATAEDALVPASMVNAWIYCPRLAVLEWGRGEKARSVDLIAGLRAHQATESGPTPALPDPMVLREDQSLKTRKLSLSSERLGLTAELDLLDVEEGVVIPVEIKVGKRPSVDEGAYLPERAQVCAQALLLREAGYTCLEGALWFAESRERVTVDLTEALVTATLVATSDLRLTVASGRLPPPLDHSAKCPRCSLLPICLPDEIAWFRKGSIARTPPPPASPALPLYGQTPGARIGKKDRGGSVCLDRMAAWLSSRPVPCYAAIGMLNTASGASHPSVARHADGGASARSFRLPTAFRRPVRRSLPCYAAR
The following text describes a protein:
Function:
Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.
Subcellular Localization:
Secreted.
Sequence:
MWLAILLALCCLTSDTHGARPPDFCSKDLISSVKPGFPKTIETNNPGVLKAARHSVEKFNNCTNDIFLFKESHVSKALVQVVKGLKYMLEVKIGRTTCRKTMHHQLDNCDFQTNPALKRTLYCYSEVWVIPWLHSFEVPVLLCQ
The following text describes a protein:
Function:
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Probably by regulating cGMP levels, required for activation of gametogenesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNEYNNDNMEQEKEKKKEEQKYKNIIKKEYFIFPRLYDKNKEIEYNKLRIHNIKEYICIHLTISLFIILIECFVFSFNLNIKDTTYVEICVVIFSILNCLMHIVVLIKMYFFTSESVYTKGVFIGYIVLNQVFQFLSLYFFTKRNEQSKNDIAHLKYYDNSFNLYVHFFVDSVFILCLPALSFFLSVLFMMMFLCLNILLINMIKFNKTNYGSDIYHICLLSVVLLMFLILRYMMEERNRLLFFFIKDMMFDNYKKWYSDYIGAHYDKDKDSTTINGDNNKYEKEKCEDYKFLFSNKCILFHDFTLNACYKDYYSMICFLNKLLKSCNIKEDMSSNTSVNINGDTYQNMNFHDNINSNIPKNYNSFYEELKKNLNESDILTIAYEVEVLKNIKKINCDEIGKNWDYSFIDSEYGKSTLVILEVGYHLISPYIENNENKKKKLQLFLLLINSMYFPNPYHNANHGATVCHLSKCLAHITDYDSYLNNTYMICYLIASIAHDVGHPGKTNSYLSETNHILSIRYNDMSILENYHCSITFSILQLIGFDFLINNEDTKLVEKNNYTNMRKFIIELIISTDMKLHFEYVDIFKKRKKSQNFDISDTDAINLGTINIKLADIGHTCLKWKDHAKWTMLVSEEFFSQKRVEELHKNKNIDPLNFSNFGKEDNIDEGMIFNYENIYINYINNINNINTYDYSYIKLNFIHHHDFVKSIPSTQVYFFEIIVMPLIKELQSMEKSKKEITQKVLHNLNINLQTWRLIEKNINLFYNTEKMTGTDYYKNLEKQKLLRGIRLLDIAEEDVISLTKNFKEEIKHGKL
The following text describes a protein:
Function:
Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G-protein coupled estrogen receptor 1 (GPER1). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane. Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner (By similarity). Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2. Together with CALCR, act as a receptor complex for amylin/IAPP (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.
Sequence:
MATPAQRLHLLPLLLLLCGECAQVCGCNETGMLERLPRCGKAFAEMMQKVDVWKWCNLSEFIVYYESFTNCTEMETNIVGCYWPNPLAQSFITGIHRQFFSNCTVDRTHWEDPPDEVLIPLIAVPVLLTVAMAGLVVWRSKRTDRLL
The following text describes a protein:
Function:
Probable chloride channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWQLIEHYYSQNYTVFWLAEFFHSWPHISYNGLKKQDSTFDPTNQKYIESLIFWAAVPILWLLLTLVLSLFFSCCLCCKRRRSLDPSRARLSVNCPQRFLIIASFVCLGLLGVGYYGNETTAIGIHHFINSANGINDTVTNVDYKINKIEDDLGSIIPSEVASLESELRKNVSNTTALGIMLEMTASLTQASEMAAANLTEISEKISLSGLDSSQLISNIKYYDYFRWMGMTLILTFQVVTCLFILLAASKASRYLLVLSSILCIVCILMIWCLVGAELFIEVGLGDLCVDPSQYIMTETSKKSEISQDVLEYYIQCTDSSLNPFSLAITEANNYLASAHKSVFSLEGMVREYAPSSQTYVDAVGVALADVSEYTQHVTALVDCTGIHKDYITALNGICYHTIAGVGFLLVSGIVLGLLITLVLCMSSTLAARIARRKINYEVDQEDPFLPTPNSTATLERFRRRGQEPTDSARVTPPLAPISPTRPHSQHGFGSRSVPSPPRYHRYEPPFEMVNPRPPAGRTSYVSHQRDSYMEDSVTTTRGNYDTPPPTYTMAMRRDGNRRTPDGRSAREEQSNQNRLSAGSASLV
The following text describes a protein:
Function:
Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins. Specifically methylates the second His of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid), while exploiting the first one as a recognition signature. Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins. Constitutes the main methyltransferase for the 1-methylhistidine modification in cell.
Subcellular Localization:
Endoplasmic reticulum. Mitochondrion. Note=Colocalizes with membranous compartments such as the endoplasmic reticulum and mitochondria.
Sequence:
MRLLAGWLCLSLASVWLARRMWTLRSPLSRSLYVNMTSGPGGPAAAAGGGKDTHQWYVCNREKLCESLQSVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPDQFQRLLRINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIRSVLEPTQGRVILALVLPFHPYVENVGGKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVVEAFTRLPYLCEGDMYNDYYVLDDAVFVLRPV
The following text describes a protein:
Function:
G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration. Promotes self-renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways. Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalisation. Also plays a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFLPNATRLLLGDLLPAVTGAASSTTGQEGAASGDYSPYSTTTMEAAHNDTTTIPDWWQPKILRPPNVFLSSFLSLLLSFTIVMDLVGNSFVIAAVTKNERLRNLGNIFVISLSVADMLVAVYPYPMTLIAILNNGWTMGKLHCQLSGLITSISAVSSVFNIMVIALNRYCYICHSLLYEKIFTGRNSILILIVTWLMTMLALIPNYYVTTVQYNPQVYTCSFVYTSSAIYAFGVMALHFLIPLTVVAFCYLRIWILVIQVNHRVKVTKPKFMLVDVRNFMTMFLVFVLFALCWGPLNFIKLARVFDPLGIGPSIPEWMYIGSYYLAYFNSCVNAMIYGTLNQNFRKEYQRIVRNTKESAYYFVVDLQEQIHEMRMRRKPTYAGARRIQGDTYL
The following text describes a protein:
Function:
May have a function in stress-related responses of the cell.
Sequence:
MVQALTASLMAGALLARGIIGAKADPVNFAGIGGAAYEYNYTATGSFNQSIMPANFTPAGGIDTNDSSPTYHPFSDFDYQSLSLALYHEYIEYDLFNYGLTKFSDAEFDEAGIDAEYRHLIRFMAQQEIGHIELVTNMLGPNAPKACSYQYNFDTVGSFIDFAQTLTKWSESGVYGFLPHLDSRAAAALLLQSITTEARQQMSLRQLQGLFPYPVWFETGIPQSFAWSLIAPFIVGCPAENEKLVWQNFPALHLVSPPVHTNFTNGSFPQYPNGTYMYPAAVSTNRTFPLSLPGQSVELAWDAPGMAVGPNSSYITSTSAGTPRYAAWISQLNVTYAPLNITGNNSGVTYQPSSHLYNDSTQQVINGTNFLVLVDEAIPVTPFNITAINEHVVAGPLVYESG
The following text describes a protein:
Function:
Acts as an E3 ligase mediating SUMO/Smt3 attachment to septins and PCNA. May be involved in chromosome maintenance.
Miscellaneous:
MISCELLANEOUS: Present with 149 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Bud neck. Note=Present at the bud neck in early M-phase.
Domain:
The SAP domain is required for nuclear targeting; The SP-RING-type zinc finger mediates interaction with UBC9 and CDC3 and is required for E3 activity.
Sequence:
MINLEDYWEDETPGPDREPTNELRNEVEETITLMELLKVSELKDICRSVSFPVSGRKAVLQDLIRNFLQNALVVGKSDPYRVQAVKFLIERIRKNEPLPVYKDLWNALRKGTPLSAITVRSMEGPPTVQQQSPSVIRQSPTQRRKTSTTSSTSRAPPPTNPDASSSSSSFAVPTIHFKESPFYKIQRLIPELVMNVEVTGGRGMCSAKFKLSKADYNLLSNPNSKHRLYLFSGMINPLGSRGNEPIQFPFPNELRCNNVQIKDNIRGFKSKPGTAKPADLTPHLKPYTQQNNVELIYAFTTKEYKLFGYIVEMITPEQLLEKVLQHPKIIKQATLLYLKKTLREDEEMGLTTTSTIMSLQCPISYTRMKYPSKSINCKHLQCFDALWFLHSQLQIPTWQCPVCQIDIALENLAISEFVDDILQNCQKNVEQVELTSDGKWTAILEDDDDSDSDSNDGSRSPEKGTSVSDHHCSSSHPSEPIIINLDSDDDEPNGNNPHVTNNHDDSNRHSNDNNNNSIKNNDSHNKNNNNNNNNNNNNNDNNNSIENNDSNSNNKHDHGSRSNTPSHNHTKNLMNDNDDDDDDRLMAEITSNHLKSTNTDILTEKGSSAPSRTLDPKSYNIVASETTTPVTNRVIPEYLGNSSSYIGKQLPNILGKTPLNVTAVDNSSHLISPDVSVSSPTPRNTASNASSSALSTPPLIRMSSLDPRGSTVPDKTIRPPINSNSYTASISDSFVQPQESSVFPPREQNMDMSFPSTVNSRFNDPRLNTTRFPDSTLRGATILSNNGLDQRNNSLPTTEAITRNDVGRQNSTPVLPTLPQNVPIRTNSNKSGLPLINNENSVPNPPNTATIPLQKSRLIVNPFIPRRPYSNVLPQKRQLSNTSSTSPIMGTWKTQDYGKKYNSG
The following text describes a protein:
Function:
Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain.
Subcellular Localization:
Mitochondrion membrane. Peroxisome.
Sequence:
METDVAREPETIEVLSQHKFDCRSLENYLNKHLPGFRAGAEPEAKLTVAQYRSGQSNPTFYLQKGFQAYVLRKKPPGSLLPKAHKIDREFKVQKALFSVGFPVPKPLLYCNDASVIGTEFYVMEHVQGRIFRDFSIPGVSPAERSAIYVAMVETLARLHSLNIQSLQLEGYGRGAGYCKRQVSTWTEQYQAAAHQDIPAMNQLSDWLMKNLPDNDNEENLIHGDFKLDNIVFHPKESRVIAVLDWELSTIGHPLTDLAYLTMFCFWPRRVPVINQISNLQENKGIPSMEELISIYCHCRGINSILPNWNFFLALSHFKMAGIAQGVYRRYLLGNNASEDSFLFASIVQPLAETGLQLSKRTFSTPLPQTDAAGQLFGQTRTGQEVLTRVKHFMKQHILPAEKEVIEFFVQNKNSVDEWKKPLVIDKLKEMAKAEGLWNLFLPAVSGLSQVDYALIAEETGKCFFAPDVFNCQAPDTGNMEVLHLYGSEKQKQQWLEPLLQGSIASCFCMTEPDVASSDATNIECSIQRDGDSYVINGKKWWSSGAGNPNCKIAIVLGRTKNNSASRHKQHSMILVPINTPGVEVIRPLSVFGYMGEGRGFEIAQGRLGPGRIHHCMRTVGLAECALQIMCERATQRVAFKKKLYSHEVVAHWIAESRIAIEEIRLLTLKAAHSIDTLGSAGAKKEIAMIKVAAPRAVCKIIDRAIQVCGGAGVSQDYPLANMYALTRTLRLADGPDEVHLSAIAAMELRDQALRAKV
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Sequence:
MHRNSPTTNTNRNNPVLNRGAPNLNNNNNNSPATNTNRGNPILNRGAPNLNNNNNISPINSPIVNRNNPPLNRSSPTINTNNNPNTPPNINRNSNPALNRSNPTINTNTNTNTPPLNRSYPSINTNVNTNTPPPAINRNNTNTPPPNTNVNTNNTNDNKPDDKSKDEKDGNEINWQDIVDRQIVGSGYIDFGSILDINGKVLASKNITINEEEAKQFIKDLKNNEQILKLAGKKYNTMINKDKEYYHGKEGNNGIFCLKTKSNYIIGHYCEYHHYDNPFPKKSQIVIETVAKNMKEINL
The following text describes a protein:
Function:
Zinc chaperone that directly transfers zinc cofactor to target proteins, thereby activating them. Zinc is transferred from the CXCC motif in the GTPase domain to the zinc binding site in target proteins in a process requiring GTP hydrolysis.
Sequence:
MTMPIPTNLITGFLGSGKTTAINRLLTHRPDGERWSIFVNEYGMVTVDEMLIDSESPEVSVQELGGGCLCCTVAFAFDAVFSQFIRRSKPDRLFLEPSGAGHPAALIDKLRDENFRRAIDLRATICLVDPEDWSKPQWRDSEVFHDQVQMADVVAINFTDKRDPELTQQCREWIESFDPPKMLIVETDHGRIDPAWLDIQNTVVRPPKFGEAHSHNHSYAAGHVDAGGLTSIEAPPMLGKPKRIENEGDGQWACGWIFSVDEVFDRDQLLDLLGYLQPVVRLKGVFRCQDDWWVINRSKNETSFSTTAYRRDSRLEVITDRATSGWDEVEQLLLKCK
The following text describes a protein:
Function:
Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MLPEHGFEHDQPTNPLHSNDVYPQKSGAVPLWFLSPKEENEVREETRRLARIACADVLKVFSDCTKGRTVSMLWACRIEKANMMECMASHSTMEDFDRARDEFVQKKADAMAENKERLARERTKSN
The following text describes a protein:
Function:
Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Plays also an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA.
Subcellular Localization:
Nucleus.
Sequence:
MIQQPTTAKPRISTSSKLNTVLSKNKENVPGKLFKKFKCPSLVISEKRKELPLRKKPRVNYSEYGSVDGKYDSAYVSENVSGLATIKEANRLILNHERRDPSTVIKKQFSVPKPIKGHEDISKLCAHRPPPTLGMKRKVDFIPRPLYDPADEFAIVLYDPTTDADEIIPDIKEVLAEKRKKDELLKNRKGKKEISDSEPESDHDSCVSTDTVASCSTEQSLITSNTSKHRRPNKSLKDLLGIQKEKPPPPPVAVVIDPKLARILRPHQIEGVKFLYKCVTGRIDRCANGCIMADEMGLGKTLQCIALLWTLLKQSPQAGKPTIEKAIITCPSSLVKNWANELVKWLGKDAITPFILDGKSSKQELIMALQQWASVHGRQVTRPVLIASYETLRSYVEHLNNAEIGMLLCDEGHRLKNSDSLTFTALDKLNVQRRVILSGTPIQNDLSEYFSLLNFANPGLLGSRQEFRKNYEIPILKGRDADGTEKDKENGDAKLAELAKIVNRFIIRRTNDILSKYLPVKYEHVVFCNLSEFQLSLYKHFITSPEINKILRGTGSQPLKAIGLLKKICNHPDLLNLTEDLEGCEALFPPGFIPRELRGRDRNIDSSLSGKMLVLERMLYQIKQETDDKIVLISNYTSTLDLFEQLCRARGYKALRLDGTMNVNKRQRLVDTFNDPEKDAFVFLLSSKAGGCGINLIGANRLILFDPDWNPAADQQALARVWRDGQKKDCFVYRFIATGTIEEKIFQRQSHKQSLSSCVVDEAQDVERHFSLDNLRQLFQLNDHTVCETHETYKCKRCRDGKQFIRAPAMLYGDTSTWNHFTNPTLDRIEDHLLKREAGKQQVSTVFQYKSH
The following text describes a protein:
Function:
Selectively inhibits voltage-gated potassium channels rKv1.2/KCNA2 (IC(50)=331 nM) and hKv1.3/KCNA3 (IC(50)=503 nM). Partially inihibts rKv1.6/KCNA6 (IC(50)=9983 nM).
Miscellaneous:
MISCELLANEOUS: Negative results: does not affect the following channels: rKv1.1/KCNA1, rKv1.4/KCNA4, rKv1.5/KCNA5, Shaker IR (with inactivation domain removed), rKv2.1/KCNB1, hKv3.1/KCNC1, rKv4.2/KCND2 and hKv11.1/KCNH2/ERG1.
Subcellular Localization:
Secreted.
Domain:
Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).
Sequence:
MCRLYAIILIVLVMNVIMTIIPDSKVEVVSCEDCPEHCSTQKARAKCDNDKCVCEPI
The following text describes a protein:
Function:
Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development.
Sequence:
MDTFDVSDRNSWYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQDQIVYRIGDQSFDNLPKLLTFYTLHYLDTTPLKRPACRRVEKVIGKFDFVGSDQDDLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQYDDYMDEDAIDKNEPSISGSSNVFESTLKRTDLNRKLPAYARVKQSRVPNAYDKTALKLEIGDIIKVTKTNINGQWEGELNGKNGHFPFTHVEFVDDCDLSKNSTEIC
The following text describes a protein:
Function:
Mitochondrial mRNA maturase required for splicing of intron 3 of the cytochrome b (COB) gene, containing its own coding sequence. In vivo splicing requires the formation of a ribonucleoprotein complex together with the imported mitochondrial RNA-splicing protein MRS1. The complex seems to stimulate the intrinsic ribozyme activity of intron bI3 through binding to and stabilizing specific secondary and tertiary structure elements in the RNA.
Miscellaneous:
MISCELLANEOUS: Encoded from partially processed COB mRNA that terminates with the in-frame coding sequence of the third intron.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAFRKSNVYLSLVNSYIIDSPQPSSINYWWNMGSLLGLCLVIQIVTGIFMAMHYSSNIELAFSSVEHIMRDVHNGYILRYLHANGASFFFMVMFMHMAKGLYYGSYRSPRVTLWNVGVIIFILTIATAFLGYCCVYGQMSHWGATVITNLFSAIPFVGNDIVSWLWGGFNMEDPYYSNMMLNKSVLCWNIFIWMMNYYIIQLIIYNNMIWNKNNMVKMFIMRRKLAVINMYMYMKLIIQRTYSYYMNNTIIYDKNHKLNTDNPIYAYIGGLFEGDGWITISKKGKYLLYELGIEMHIRDIQLLYKIKNILGIGKVTIKKLKMKDGTIKEMCKFNVRNKNHLKNIIIPIFDKYPMLTNKHYDYLYFKDNLLKDIKYYNDLSYYLRPIKPFNTTEDILNKNYFSSWLIGFFEAESCFSIYKPMNKKMKTASFEVSQNNSMEVMLAIKSYLKITQNIYTDKFNNSRMTTKSINGIKNVVMFINNNPIKLLGYKKLQYLLFLKDLRTITKYNNYFKIPPKY
The following text describes a protein:
Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Sequence:
MRQVCPRPERPSLAPSPPISEPSAQQATDTGYVAVGEGHASARSDSVSVSDVASAPVIPLETILHTRRHLAILGEPGAGKSTTLQFIGLSYALATAQQPVERLSITRPAVPVYLRLPVSASTITQQTVREAMVAEVRDRLQCSAAEAEAVLRSWQEWPGVIILLDGLDEVPVALRVQVRERIKTLMRSGIGRVIITSRPSVLLHLGGLDEYTLKPFEHFDRDVLPYLKGWLRVLKPDLQAQVVDNVAQDVMTKLRASPALRSLIGNPLLLRLIVQYFVTTGDIAWNRADLYRQWVTEAWARARWRGAAATEEPHYLIALHTLAWHLHAGRDNTETALQTVLRTSGLAADDRAAADLLHRLQAQTGLLLRLSTGQDGLAHVRYVFAHQTLREYLVALRLQQAWQRGKHRTWRFLQPRLHLPEWREPLALLVGLLTESEAQHLLRQILHAKSSEERLLCRDLLLTANLAVESGYIHSVWESLAPKLARALRREHLSKETAAVLARVGKPAVPMLAQALNDPSVEVRRAVVQALGLVGDAAVPVLAQALNDAQPEVRWAAVASLVAVGNAAVDTLVQALGDDDAEVRRVIGQALLEIGDAAMPALVKALADKRANVREAAARALGESGYAAAVSALVQSLRDENPWVRQAVAEALGAIGDAAAVVALAQALNDENVWVRQATARALGRIGGAAAMLPLTVALNDENPWVRQAVAEALGTIGDAAAVLPLTRALSDEHAWVRRSAARALGQIGDGAAVPALAKALSDGDVQVRQQVVEALGCIGDSAAAAALVKALGDTNAEVRWTTMKAFEQIGSRNVATLLRAISDGKWQFPWQDAQAWKIGNQAIEAIGSVFNGGDTGKRMIATLALGETGNSAALPALERALRDTDLWVRRAALEALAKIGDQAVIVPALERALRDTDQWVRQTAAEMLVKIDDTAAVLPALERALRDADQWVRRTAAEALGKIGDASAVEALQRALADTESMGAAGRSRGARKDRRCVGGGGAAKGIGRYRSMGAAGRSGGARKDWRCVGSGGAAKGIGRYRSMGAAGRSRGVGEDRRCKSGSITDTVTE
The following text describes a protein:
Function:
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
Miscellaneous:
MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRTRTEIVSTTQTSATWRDYFQLCKPRVVLLMLLTAIVGMCLASPGIVSWRVFLFGNLGIALAASSAAAINHLLEHHLDKLMRRTYRRPIVQGKINRKNAAIFAAILCILSMIILIAFVNLLTALLTFITLIGYAGFYTLYLKHATPQNIVIGGLAGAAPPLLGWVAVTGHIDPPALILLLIIFLWTPPHFWALAIHRIDDYAKANIPMLPNTHGIIYTKINILLYTLLLTAISFLPFVIMTSGWIYFSSVCLLNLGFLYWAIRLLTSQRKEIPMRTFQYSIWYLMLLFTALLVDHYVYLALKLY
The following text describes a protein:
Function:
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
Sequence:
MSETHTSDETEARDQLLAIAEQFYDQFADGDIPRMSLPTRSKSNIEYDEDADVWVYGDSQSTRSANSVRGARKLLKSVYTVDFLAQQLDEGRSSTLRELYYLSESWDEAEAQFNDQSESDKLVEDLEIVSGVKREDFHMRPEESGAKVMGPLRLREQTRRGDREIHCQEDVGQGGYQIPNNPDTIDFLDTDADFVLCVETGGMRDRLVENGFDDDYNAIVVHLGGQPARATRRLTKRLHDELDLPVTVFTDGDPWSYRIYGSVAYGSIKSAHLSEYLATPQAQFIGIRPQDIVDYDLPTDPLSDSDVNALESELEDPRFQSDFWTEQIGLQLDIDKKAEQQALASRGLDFVTDTYLPERLAEMGVL