lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MPPRINLFTVGKALPGFRPSSSCAVSSRFSINRTHAASTVQAQRRWNSSKSEKKDDLDGLKGPTEDPLPHVSEEAAQMDKILHGGKYEAAASPELEQGTPVAEILQRDKDALKHMPKVMQDQLKRSSGNRSFSTFTRRYQPDLQEQEVTDPSVAVVANMINQVNQEVAELHPGLKFPAPESLPKTENFRERYDPLLEQFTKLLMRDGKLSKAQKNMSFILDHLRTAPPPQPHPKRRLLPGPPSPQLPLNPVLYLTLIVDSVAPLIKIRQQKGIAGGGAAVQIPVPLMQRQRRRTAIRWIIDASDKRRDSSFAQRVAHELVAVAEGRSGVWDRREAVHKLGVAGRSNLGLVTQRR
The following text describes a protein:
Function:
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLSIIKYISCFFVILYSVVKEIFKKIVPSKPKNISGKVVLITGAGGGIGRQLALKFAAQKTKLALLDIDKATCDETASQVSALNAPCHSYVCDVSKKENVARVAQMVRRDLGEVDILVNNAGVINYKNFRNQTEEDIKRIVNVNLMAMFWTIQEFLPEMYRRNDGHIVNVSSVAGCIGIGNMEDYTATKYAVRGLSEALAHEFSHKMTNLHVSIVYPTGVDTPLVHRCIPDKDMLFMFMSPEKAAQIILDGVLTNKLHIFVPSHLWLVAALNKLVQQQIQHAAFVSI
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono-, di- and trimethylates elongation factor 2 (EFT1/EFT2) at 'Lys-509'.
Miscellaneous:
MISCELLANEOUS: Present with 1550 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MNEDLFYDRLHQRCPGKYLLEELETSKSNDVLHASRFVCEMELVQKTNAYYCKTIVKMLLDHEWIFAKAFTIVNDGEDEIEIYDYLYEKYIKLLSTGKPDPMMKDVVRYRFDEDVKIKIEETPNLISAASTTGFRTWEAALYMGDFLIHKPLQELAPVQGQDDGKKKLNVLEVGAGTGIVSLVILQKYHEFVNKMYVTDGDSNLVETQLKRNFELNNEVRENEPDIKLQRLWWGSDRVPEDIDLVVGADVTYDPTILPDLCECLAECLALDRCKLCLLSATIRSESTVQLFSQECNKLGLKCTIVTSTEYDANNEIRAMKALQFKPLIAPIRIYKITKQ
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEKNNHTITEFILVGFTTDPVMQLVLFVVFLGVYSGTVIGNTTLMVLICKDSRLHTPMYFFIGNLSFLDLWYSSVYTPKILLTCVSEEKTISFAGCAAQFFFSGGLGYSECYLLAAMAYDRYMAISKPLLYSQAMSIKLCAFFVAASYLGGFINCYQALMYFLLASNVITPAMLILASYLFIITTILRIRSTQGRLKAFSTCSSHLISVTLYYGSILYIYSRPRSSYSSDRDKIVSTFYTVVFPMLNPMIYSLRNKDVKEALNKLFK
The following text describes a protein:
Function:
Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Associated with actin filaments.
Sequence:
MIPNGYLIFEDESFLDSTVAKMNALRKNGQFCDVRLQVCGHELMAHRAVLACCSPYLFEIFNSDLEPHGISHVKFEDLDPEAVEILLNYAYTAQLKADKELVKEVYSAAKRLKMDRVKQICGDYLLSKMDSQSAISYRNFASCMGDGRLLGKIDSYIQEHLLEVSEQEDFLKLPRLKLEVMLEDNLTLPSNGKLYSKVIGWVQRSLWENGEPLERLMEEVQTLYYSADHKLLDGSLLDGQAEVFGTEDDHIQFVQKKPPRENVHRQLSTSSSGSLSPGSTKHPCKQEWKYIASEKTTNNTYLCLAVLNGMLCVIFLHGRSSPQASPSATPCLTKSLSFEGQPLEEEPDKLLSPMHYARSGLGIASLNDQLIAAGGYNREECLRTVECYNIKTNSWTFIAPMRTPRARFQMAVLMGQLYVMGGSNGHSDELSCGETYNPNADEWTQVPELRTNRCNAGVCSLNNKLYVVGGSDPCGQKGLKNCDVFDPISKAWTNCAPLNIRRHQAAVCELDGFMYVIGGAESWNCLNSVERYNPENNTWTLIASMNIARRGAGVAVYEGKLFVVGGFDGSHALRCVEMYDPVRNEWRMLGSMNSPRSNAGAAVLNDVIYAIGGFDGNDFLNSVEAYNPKTEEWSTCADAFTDS
The following text describes a protein:
Function:
Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MVNGIKCMQNPLLEGAKNTESKCSYSCSQSLTFLNPVVKLHNCSNMKRLIRCTNLRVSSTKTENTCPSATVKELDLQKQLPCPVNTVNSIVSTDSTIEGNNSKKLQSITNGLANRKIKRILKVKWDFGKKTKNSTTCPNEHTQADSAASVKQKTEDLKHSSNCSINTEPSDPCIGTLERNIEEMNNNKSDSVNWNMMETLYDQSTSQNKNESYVCPPEVCRTTQLPLIVSKYKRNDRESLDLECSALIRTSVNEPVVGGFSEEDVNFVNNHINENVEECKTCSCQRTIPFTGKTIWKCSCARTCVWAFPRKRASPLTSTDILGLDSEWSLTPYPSDINTLFQSNEAETLQSIIDDTDSEGICKKPKLDFISEKNTLDIKGINNEGLPRHHSETPELPNTVIEEVFNITENMHSLDEENIYENFDSWTCSSTSIQNTINILTQPLLDDENVTSLSSATFSEMEPFLQTFDDMAPSSSFENSEPSVYSSASSMEPECFLLSETVQKSIHVSPIHECLDNEKENHNDEEELSFFDCMHETANDNTCLSEEHSTKQLDNIVDPLDDSNSSDLALTRVKSPKKSKLMEFRSNSDVMKAYEDDVLFIDVIPDDPDLFGNLKEPYKSPAYNADNSETNKQNYLSALMCNLLEQENAQIIESKNDVITEKNQEERSTCFAEVITDQEVKNDPLIKHNTLEENSEDFYDGEQSDSEEFRDHLGIDREVKYAEKNSSESGSSLSFESSSKDASPGSSRSHSRLWRRDPSHTFKPLHWMNDFRYSGKHIVMADVLTSDQKGPWNLDDAFYDCKPIQKTLLPVWYCKYFFNTFRGCMKPNCLYQHVPYQRDEKVCMEVIQKLLNENHTSLLKRAVWIFTNYYRKYVPGVHYNCNLLTKILHALYVRQIWGDVFHLLETGANVNILPTSDMLIKLFENIANAGLTTAVPSLMDVFCKLVEAGMMLKPEEINVLITAMNHLQASKNYISIILDIKTRFDMQHSKKNWLCNLKIAVAEVGHCKEKNDWKKLGTLYLNLCKGCENVTDLKKFSICIVGALQKETKDDKSEVPYWDFADTVYRDAQLSEIDKNILGRIGISIMYHYSRNKHWQKGKKVLRKLQEMQINFTVLNGLTGDESKATRCQVVNTAVEIFLNCEHLNDALAVLRESEWIINTQMWPCERMDVLNRHNLLCTIAYETLNKNKFDVCLEVLQNLPGLQCSLTDVDVSQYSLLFSKLLGSCIENNTLGVSSNVIDFMVAKKIPVDFFLLRALITSLGRSCLWLRARELYKCAISLGCYPPMEGNLYRKVLFIPCFLSEIEMLLSIEIFMVSNASSIQSPGGSNQILQIILKRCEEERVQHKDYPRCKDGYQDAVNRLVQATRFSTPRLCIKQMTVNNANEQVYILDYTCSLKWLHENMKWAGKVWLFQ
The following text describes a protein:
Function:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Sequence:
MGNSSGSQRDQAFSDSCDDLTTYSIAQATEALEYYNMGRQPPRYKLTENGCGIKRLSDRLSESSDIPTTPSTIPTLFRWTKAADTVQLMGSFDGWTNIIPLVNCGDEFLVIIDLPVGEHQYKFLVDGEWTIDADEPHVENGRQSFNNQLIIKESDFEIFRALKADDKTTEKLDVGFGQELPPNMSSHHRPPTIPPQLLQITLNKELPVPCDPEILPVPQTPELNHLYALSIKGGVITMSSMHRYKKKFISTVFYQPT
The following text describes a protein:
Function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Sequence:
MRNIVQKYLQRNSTKLFNRTSVFNLYKKCNFSGYKIYSDGLVHSEFSTELKTVNEVIKMPIYRILDTNGHLLDGHEAPFKDEEVLKIYKDMVEFSIWDEIFYGIQRQGRISFYIVNEGEEGLQFGMGKALSVDDHLYCQYRETGVLLSRGFTYTDILNQLFGTKYDEGKGRQMCICYTKKDLNIHTITTPLGSQLSHAAGCGYALKLKNQKAVAVTYCGDGSSSEGDFYAALNFASVRQSQTMFVCKNNLYAISTSIKDQYRGDGIAPRALALGIESIRVDGNDLFASYLATKKLRDICIQESKPVFIEFMSYRYGHHSTSDDSSLYRPKEENEAWRQEGVHPISRIFLYLKNKNLYSEKEDQEHRKSVKENVLKELKKYESVKRYNIVGGLFEDVYHEEDWNIKEQRENFEQFFKENKHNYDTSKFER
The following text describes a protein:
Function:
Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
Subcellular Localization:
Preautophagosomal structure membrane; Multi-pass membrane protein.
Sequence:
MINDDFSWKSIYNYYYQKGLTVYILECLFKIISSLVIAFTPILLFGCLNWEKMDSAKTISEIILPFPKGWMNSNIFFKISFILFLIYSLILIIQFVSTLPLFISLHKYYSKKLGLSDKDLIVIEWNEVVESIIVCDPLKSISTLSIAQQITREDNYLGGMVEDQSVFTWRLPWKKEMEQLPMNSSFFYFLKMSLQGTIFNSDGVPLICGVQNIQAAQNQQKLKSRFRIVGVLMILIAPFALIYEILNTIFAYIESIRASPDDLSLRQLSPIVRFKAREFNELPHTFDKRVMKSYEWADLYLDQFNQSPLVPVMRTFSFLAGSIIAIVFFVGIISDIPKVLGLEIFGGKTIAWLITILASVYAACKPPRPPTNMYGLGPDELFVELQKHIHLDLSDSRNSPHSWETYDNVDRAYPPIWKHALINIASVIINPFLFIAILPLKASSIVEFVRRNSVENSEIGWICALGAFEDPQRYSASPEHRARLNRSNAAYDSNKVQIHLEPIREDSNDLLKSIYGQPAEQTPEKEPMGDENLVGFGIDALSPNEFYVPENDAIPPPPDSMV
The following text describes a protein:
Function:
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
Sequence:
MEWNGRVDGYDEDILRIHQVIQVKNLDELMENDYTGKKVCFVSYNSNEGIRRNNGRLGAADGWKHLKTALSNFPIFDTDIKFYDLKDPVDVKAGKLEEAQQELAEVVAKLKSKDYFVVCMGGGHDIAYGTYNGILSYAKTQTKDPKVGIISFDAHFDMREYNKGANSGTMFYQIADDCKREGIKFDYNVIGIQRFSNTKRLFDRAKSFGVTYYLAEDILKLSDLNIKPILERNDYIHLTICTDVFHITCAPGVSAPQTFGIWPNQAIGLLNTIAKTKKNLTLEVAEISPRYDYDDRTSRLIANLIYQVILKHFDCEIN
The following text describes a protein:
Function:
Required for stress adaptation, morphogenesis and virulence.
Sequence:
MISMNPIMIRNNLSRSSSPAAPPTTNHSSTVDYFSIKPKLSLDINSQSDSNSTQSNNNEDTHSEQSDYNSYTHNQYYDSDDDEDDFDIRDQLLDPFDKITLSNCNEEYYSPLTPFDGQTTSPQDSIISSKSSNKSTTVVPSPQFQLTLPKLTTYSFLIVDDNIINLKILNRILLKLFPKCHIVQIQDSKLVKDLLHKQSFDSIFIDIEMPDVNGIDIAQFVRQDTKFDNMGMVAVTTRNSTQDLELFKQCGIDFTFHKPLNYSLDFMANSIDDIIITRKNKI
The following text describes a protein:
Function:
Calcium-selective channel required to prevent calcium stores from overfilling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAYPFSDFKYSDGLTVVGISFCTAIVCEAISWVLIYRTNSYKNLRSSIDKASKKLETMKTDSNKINIKKSKTKKIDRVETSLKESSRDLSLFKFKSGGVVALVLFVVFGLLNSLFEGKVVAKLPFKPFGLIMKMSHRGLQGNDPTDCSMAFLYFLCSISIRTNLQKFLGFAPPRGAGAGAGLFPMPDPKTS
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MGTVPDPHGSSKSPLVTSPKEKDSSASDTLLQFTQGTLENNGSGISVSETFPVNVICSSNMATEQEKQESGNTTSSFRTCNELVLLPPLVPQAIKDSTQPIPSIRNTYLSTDGNAESCSNHEEKTAKDSISVTPSASVEADMKVPSDLKNRPLVESGADKGLVNSVQNKEEDPSLITHKTESINSGSQNIYAVTQSEKVTTVEGEPVKKSSTKSDEYQQLSFVKDKIKTENEEVEMDPMLPSRFKEMGTMTSFSLENWTTQDAEVQAVANVENKSVSTSPSILAAFLKANSPVLKERQEQVCIIYQGNPGASQLDRANFALQAQLSQNQLGPKLCFQAPDALSSQPLQMHAKSSPDLARPAFQHTEIGRNSQILYRNELEGQQLCFREMPQMQMASPSPILMNVKPVYQINIENSAQPKPRSMDMYSEPSHFRAPEVNNKSRLHHLSGVENIQLHNIRIDNDQTDTLSIPGDDSTDRKPFHFKITNEQGSTQAIITTDIKKPKKEDKPTPLHVEVEVNTIGATGGQADEILEVLIRKDQDDNALAKRSSSFSLQSRPASDISAAQLTPRLRKAREEKNEPLLVTLSTSEQPKLHGKKATPPSSNAGAKTQGKQTKSVKDVVWDEQGMTWEVYGASMDPESLGIAIQNHLQRQIREHEKMIMAQLKQNRKSIGSDSSGKKRRQHRVFQSILKNFRRPNCCARPPPTSVLD
The following text describes a protein:
Function:
Mitochondrial membrane insertase that mediates the cotranslational insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MARNLVCGRWQLLRLLRPQRSYHSVAVSLRPLAAELLAARRGNGRPPCALLAVFTPRCISTSATLFAEAQVQAPPVIPATSIPAAVPEVASGGAADVVQCATEPSFTELGLGSYTPVGLIQNLLEYIHVDLGLPWWGAIATCTVLARCLVFPLIVKGQREAAKIHNHMPEMQKFSARIREAKLAGDQAEFYKATIEMTRYQKKHDIKLLRPLILPLTQAPVFISFFIALREMANLPVPSLQTGGLWWFQDLTVSDPIYVLPLVVTATMWCVLELGAETGVQSNDLQFMRNIIRVMPLVVLPVTIHFPSAVFMYWLSSNVFSLCQVACLRIPAVRTVLKIPQRVVHDPDKLPPREGFLKSFKKGWKNAEIAQQLREREQRMQKHLDLAARGPLRQTFTHNPLLQHDPSHPPKAPNSNNSSIKANAKKPWQDTLG
The following text describes a protein:
Function:
Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair.
Sequence:
MHPFGREEETSRRELFGFFRRCLQRGEWELAAACVSQLGEARAEDPHSPRDIVKAIVTHPYPLRWETVGSPHRLAWYWLQVLERPTEIKVSVSVKRELEFLLLLEELEDIPQSVLKELHEAFLYSEEVKGKAPGDSASPLSAALLSCLRSLLTRQQPRLCHSLISFLSNGDPSRDHTLQDAFIQHLTEQVKVPAKDRNREWVEQVCSVLALAPWGSDRSGAQLEPLWEGLWAAREGLMTEERILGCLLRPQSQALLMAYSSTALRLLKDKLLAEAPHTQVDLPDLERVMLGLCCHKDKRLAWKAIYFECLSSGKHFLEQVLLTGLDLIKREEFSKLETLLHSEFQPLSRLLLLLGWMHCQSLESAKTLLTVLHHRQPQSNDSALSDLACTLSCQLGVLEWCTQNNPGISHDALLSHLHMLDHHSALYVLHCLTPLAKFEEHKVLELLQRTGDPSQVDSPSSSVQRNITLFRGFCAMKYALYAISVNARTHAHTGSLDCEPLHELQTEAAQEDETAEGCSNLFQHYLSECQLYLEAVPALFRLELLENIFSLLFLSDSDFTQQTSTATETQPYTNTETSKPKSTKEVNTAEHFLKAENEGERMDELNQINPQLGHLTSGCRGFLVDLNVMEGILRLVREGLEGVCGVGQEDGRALGADVELAESLGCSVTAETFSARLQRLSKYTAEAQWRLQIVTSNHGNGNDGLYLPSPLPSPALPLKRQGSGSSGTSSRRRRKHHRHRSERHVSSERQNGEVSTSTSDGGVCVSVVCRGTETCPCGGSHSWLVPAMLSPPESLLIACIRRGNYIEAQQVIAMYGLENSECAGELVFMDRYREVLIELAQVEQKIESQSLSTSSSSSEGLGTLGATPAGRTRMGSSSRLTLKSIGSAAAAGMAFYSISDVADRLMSTPSRPIPCLEDSYWLSQCTIDSPDFVRPLVEELSPAAMAAFDLSCCQCQLWKTSRQLLETAERRLSSFLEARGVRVDPKVPHANGIRGFPSVLQQISKILNKTSTNKGMSKTDCNGEENAVCSPFGCSAQEVLLSCHSTLTEESITIQQNLNQRLEVTLQTLSSATNTSVDSLVGSNLLTALAEQAALKQSELDCHPVRTAMKQLLQYLDQLCPLVPDGAPDRPDYIRSFFDYVNVLASVLVRSLGSEDQSTVVKLGNPLLLLLQSPAQLLSHLLFDRQVSPDRVLSLLQQERLRLSVQQVVVQRCCETLPLWDSRAVNFSQRVSGLNGGAFCPASIASILQQYAQDCSPSLDLSDPTTTSDPSSESEVSVEDVSAASTSLSTSPPSPSSSSPSSSFLLTPSALSFLKSRSPLVAALACLSASRGGVTRVTSSGWSGLPSYFRGSGRKEAVLDGEQISREGEALLKNFPILRMYLRTMAEPVLGVSLEADEGLGVALCGKPVVGMLFSGLQGNAAQAMAAEAFQQALNNGDLNRALDLLELYAQPCSQEGALRDKLLAFTALQESSSAEQLFRVRDWELRGRVVLQGLDRWPLQQCLDLLHFCLSDQNTKDPLREQLQQRKQELDMYQRMLRLQPSLPWETWQELREESTKNPESVFSQMLEAREFELCAQWVQLYSVSDQSGMQLQTEHLLYLLEHNHTEEAFQLLEALSDSMGLEVSERALDRRPGLAACHFLSDYLTLHFQSQMTPARRRHIHALHLGSKVLLTLPEASRQDYFSLLSDPLLMLEQMLMNLKVDWAAVAITTLRSLLLAQDAGITTQHIDTLLADYARKALDFPYAPREWSRSDSVISLQDAFLQCPAQESCPSSPSHTPPPSTGGTPMQTPSSERRPSGKKIRPLATPFTPPEKTPDRKDWIPDHKQHICMVCQRERFTMFNRRHHCRRCGRLVCHSCSSKKMAVAGFDEPVRVCDQCYNFFHTDSDEELEQGEAGSPSSIDEVLNGVLSLPEVSRKQYRLSPNPAENQQLKSEFYYEQAPSASLCVAILTLHSDHAACGQQLIDHCRSLSRKLTNPEVDARLLTDVMRQLLFSAKLMFVNAGCTQEPALCDSYISKVDVLKILVTANYKYIPSLDDIQETAAVTRLRNQLLELEYYQLAVEVSTKSALDPNGVWQAWAMASLKAGNLSGAREKFVRCLKAPVDRNQLNHGPRLLQEIIQHLESTVKLTLSQTMDEDILASLRELEEALSDSAPPEGTESKVQRCNFHQECLFYLFTYGTHLSLISFYLRHDCLKDALTYLQNKGCSDDVFLEGIFQPCLERGRLGALQGLLENLDPTLETWGRYLLSACQLLQRRGHYHSLYQLQQFMMDHIRAAMTCIRFFSHGAQSYLQLGEQQRWLIRAKEHLRTYLQEQQSRRKSHSSSFRKKMSSTDVSRHIHTIELQLEVTRFLHRCESSPSKTAVGSTYTGNSAPPTLFGNSPMKVDVACKVMLGGKNIEEGFGIAYRVIQDFQLEALAVYIRVGQRLVRQRQYSSVRQLHKCVGESGTASKHDCDAIVLSCVSVADKSPADAKELETLILECKNPENKIKAYLQCSKLRAAYLQAVKLKLVKATPLIQEVMRAAESSGDSVMHDICRQWLSEHQEPSSKQR
The following text describes a protein:
Function:
Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSFRAVITSSEHQAVWSRLILTLSTINQDIKFTIMSNELILWSMNSTDTTMYQVRLKASFFSEFSFDPGNIVFGEEGLQVIEDLQKQQHTLYSFVINGRHLSILSRKPEYDNIKEFSLSIDNSTAAPEAIINRLHIRVYTESLITKEFSPAFNPVKYDPIVIDLKYKKKFLDVYGTEESVNGEQADPRLLDFFRQVRKQLEEAKFNEGIIDAPRPAELRSEHEINFLSMDSLIWRNAIDLCTNNTEELKLDLTMNKMVITAFTKGVQNMKSSDVLKQAISISNSVSTEDVEHYCLFTTSGNPGMSKKDADSKQAVFKLRDFRNFFSANQAWKENATVNCWFCSPGDPILFEIDRGHVKLSLVQITDTAGKAVGAAPDLAIHPVLVSPRKPVSPLRAACTNTNAASNALHGVQLDAANMDAIKTLFVQDVEIGVSAAAMAHSPANRCTDENLRSMCSISQQGQHSCDGSPATNLRRVSRAGTTIAWGAGKDHVMCPDSDYGVAQDVNQLKRRKVGELAHASQSPESQDYGLGPTQQYQPKGIFD
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MPVVRARKARVDHGSKRSISRFLVSEAAIGKLVKDISAGTDAAHPVTPRELGSGSPHDPIHLPLRRTPNGSGCYHCTTEECCCVEFEKILSNTYARVPKKRMVEVSGARQLCAKSLLTPFVTRLVRLMNITEKDTFYDFGCGNGSVLFQVAFMTGAKCVGVEISEHNADVAREAWQLLRQVLEKKYDRPMPRVEIITADLAELLSTPTYFDEEEGQTAILISNLLFPKPLTHFLSERLRSAPVGTRILCFDDLYPHARSVASYRDPGAFELFEMKDYFWQEMSVEWCSMEGRFFIHTRK
The following text describes a protein:
Function:
May be involved in protein trafficking.
Sequence:
MHICIPVTEELQDTLGCRFVLYSVYLEGFLLFKVRYKDLHLWNEQIHRVFGNGLPKFPPKHYLAMTKNMANERRLQLEQYLQQIVTDPVVTSSDIFMDYFRKLQMDTFNMPTVKLILRVYVPDGAAVELDVRTSDSAERVLEAALFRLGVSRELAEYFSLFITHKEAKGPFTVVKRIAAFELPFLTIWNLEDDQFQIEVRKWYMNPSNDVMLMGSTEAIDILYLQAVQEFQMDWTRPTKDQEQKLQHCLKEENKLKFLELMKTVEYYGYLQIASCASDYPECDSEVNVWVGNNEMSCHFHSPGGHTEHLRLNIRDLICWNVSLLQPKKQEVMSPNHQHLEFKFEYQQGSSLKCITIRTEQAFLLSSCLKKMLSEYPVHRSKEELEIQVDRAQATHKFNIRPVQNGVHTKKQTLLKDKAEYCLIDDISDLNL
The following text describes a protein:
Function:
Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MRRLFVGGLSHTVTQKELKDRFGKFGDVVDVELRTRRDEEGVPYKTFGYINISISDADLKRCLTVLNKSKWKGGTLQIETAKESFLHRLAQEQQAVANQDLQQAAADDRRQNLLDSLSKAGIDNFTMKAAVPGTEVPGHKDWVVSKFGRVLPVLQLRCQKGNKARVMKYDPSKYSHNIRKLDRCADDQSTPVSQLTWELDGGDDDISRKRRGEFPSYKPRRAKKSRPHGINICKALDRKRLEQNNSSEDDMESKQFSVGPTRTKAQLSPDSDVDSDEDICRLMAAQDSSHNALHQEAGESQLEVVGLEYSVKSGRKDCEDEYDSADTDELFASRRNVSTLINNANEKAKRRSGPLEKEEKVKAPLPLQTFSFKEDFDLGEKRNKSRVLPVLQSSSVSHSDDEEEEEEESEGSCSDSEYEAMFSHGTCLEMSFADLQKLAEDASQSSETACDRGSEENPELAPGPEEWPALKKGISPEEILAAILEESTSDEDGQNERKKPEGVSLPAFQGTKSLKEMDNTLTKEKDGRGMEVKKQMQISEAPQMNTRTSGTERQEGEKKALLQVGKRTLHKVLTASESSSSSDEEEKEEERTTGRQANVAEKLSAEIFSEEDRGKIFPDEGSVEAVPPPFHRKLNAGKEEELQRKANLRRLSALQQKQKEAEEQKRLIQGALANLDAPPPKAGKRVVFDSDDENNEDEEEKKSWAASSKKKLQDIQSEEEAVWSRAVANQRATKDKFTGPQLFDSSEEEDSAEEEDNGFHIRPQFEGQAGQKLMALQHRFGTDERFRMDERFLEEEEEMEANGSLTVEDEALEEEKKNNLSILQNVLGSSKQPSSKTLLKAAKFRDVSTLHYDPSKEEHSAFETKTIKSTESKSARRKKREEAQKLPEVSPEIFYQVSSDLKGVFGQTKEDLSNPEKTNWDQVKEEEDRGKAEELQSSLLSEDPTTTKEGSSGFKFSFFGVDAEASGRETTEYKVESIQAPKVSWQQNQCVHDSSSDEEQERQSTASTETEETPIKSMDLFFFYPGDTRLKEGPTLFCRSSQLEEQREEWEERRTTLRREVRKKHKDAQRKLKAAPKS
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MGNIICRGKNLDKQVLGGKQLGNKIGTLMTKHSKHMKEKKQVGDIDPNFVCRFCHEQVHQEHSFNIKGCAHFYCQECIVKFIVSNLQNNVTCIMCPTPGCSGLLDPEYCRPILPNDVFDLWGTALCESLLETEHAVDSTFTCDFCVEQIELKDSFNIKGCAHFYCQECIVRFIVSKLQDNVTSVTCPNQGCPGVLDLEYCRRILPYDVFHRWGKALCESVVMEPQKKYLFCPFNACSTLLIDEEPDDTKQAQCPHCKRVFCVKCKVPWHTEFDCDMFQKLRDRGEDQQLEELAKNKNWRRCPSCKYYVERRDGCSYIKCRCGNAFCYNCGVQASLTSHTRHCPSCHK
The following text describes a protein:
Function:
Regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, perinuclear region.
Sequence:
MSDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHNITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKTLLQ
The following text describes a protein:
Function:
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
Sequence:
LYKKLSLKLNGDRHVQGILWGFDPLMNLVIDKCVEMATSGQQKNIGMVVIRRNSIIMLETLERE
The following text describes a protein:
Function:
G-protein coupled receptor. Plays a role in plants and microbes interactions (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTILPFLAAVFVLQLLSTLTVAEIKSFTISNDSRPVILLEKFGIIEIGHVTVSVSSVSVLSPILDSSKLGFFVLSEESLPHVLLELQQNFSFCVLDSHYILHFFTFVDLSPPPRSQFSKSYPITSPNDYSLFFANCVPETRVSMKVHTEIYHDLYPNGSRDYLLAGSAQLPGLYLVFFLCYLSFLCFWLCFCWNHKQIVKRIHLLMTALLLVKSLTLICAAVYKHYVKVTGTAHGWNIVFYIFQFISVVLLFMVIVLIGNGWSFLKPKLHVKEKKLLVIVVPLQVLANIASIVIGETGPYTQDWVSWNQIFFLADITCCCAIVFAMVWSMCCLRETSKTDGKAVKNLAKLPVLRKFYVLVIGYLFFTRIVVVVMKMKADFTYQWVSNAAEEIATLSFYCLMFYMFRPIEKNEYCDVDDEEEIVELSLK
The following text describes a protein:
Function:
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
Sequence:
MRDISWLKGSITPIVTPFRNQTVDYETYARLVDWQIVNGGHGVLVNGTTAEPSLLTVAERNRLVDVAVEAAAGRVPVLAATGSQSHAETVELTQHADKAGADAMLVVTPYYIRPPQRGLVEYYADIAARTERPLLIYHIPGRAAVSMDLATVKAIRERAPNLVGMKHAVNDMAFVTHMLDAFGPEWRVFVGLEELSYPMLAVGACGLMNAVGNLAPRKVADLVEAVERGDYAAARALHFALFELNQSVFYDTNPIPIKYMMKRMGLIPANEHRLPMMPATRELEARLDGVLDRAGLL
The following text describes a protein:
Function:
Component of the plastid division machinery required for PDV1 localization to constriction sites. Involved in chloroplast division site placement. Required for the proper formation of FtsZ rings at the division site in nongreen plastids (e.g. etioplasts). Inhibits FtsZ assembly, functioning as an antagonistic regulator of FtsZ dynamics against ARC6, by recruiting ARC3 to the middle of the plastid to facilitate its interaction with FtsZ proteins. Required during stromule biogenesis in the leaf epidermis, especially in non-mesophyll cells plastids.
Subcellular Localization:
Plastid, chloroplast inner membrane; Single-pass membrane protein. Note=Localizes both to the mid-plastid and to a single spot at one pole.
Sequence:
MPVAYTFPVLPSSCLLCGISNRSTSFVVDRPELQISGLLVVRSESGEFFGSGLSLRRFQREGRRRLNAAGGGIHVVDNAPSRTSSLAASTSTIELPVTCYQLIGVSEQAEKDEVVKSVINLKKTDAEEGYTMEAAAARQDLLMDVRDKLLFESEYAGNLKEKIAPKSPLRIPWAWLPGALCLLQEVGQEKLVLDIGRAALRNLDSKPYIHDIFLSMALAECAIAKAAFEVNKVSQGFEALARAQSFLKSKVTLGKLALLTQIEESLEELAPPCTLDLLGLPRTPENAERRRGAIAALRELLRQGLSVEASCQIQDWPCFLSQAISRLLATEIVDLLPWDDLAITRKNKKSLESHNQRVVIDFNCFYMVLLGHIAVGFSGKQNETINKAKTICECLIASEGVDLKFEEAFCSFLLKQGSEAEALEKLKQLESNSDSAVRNSILGKESRSTSATPSLEAWLMESVLANFPDTRGCSPSLANFFRAEKKYPENKKMGSPSIMNHKTNQRPLSTTQFVNSSQHLYTAVEQLTPTDLQSPVVSAKNNDETSASMPSVQLKRNLGVHKNKIWDEWLSQSSLIGRVSVVALLGCTVFFSLKLSGIRSGRLQSMPISVSARPHSESDSFLWKTESGNFRKNLDSVNRNGIVGNIKVLIDMLKMHCGEHPDALYLKSSGQSATSLSHSASELHKRPMDTEEAEELVRQWENVKAEALGPTHQVYSLSEVLDESMLVQWQTLAQTAEAKSCYWRFVLLHLEVLQAHIFEDGIAGEAAEIEALLEEAAELVDESQPKNAKYYSTYKIRYILKKQEDGLWKFCQSDIQIQK
The following text describes a protein:
Function:
May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane. Cell membrane.
Sequence:
MDYFKTLEINNFNDYLNHLIQGNKVVIGTSILGLVIAIFIFIKIKLMRCIELDTKILHECTKKGVGLPIDEAFEAIHKELIKHYPQFITAKRNWLLFNGGGAMGQMCVLHASLSEYLIFYGTPLYSQGHSGRYLMDVYDFMIQGTTKQFFPGKFQSIDFPAGKFSYLPMMVAKGYCCEPNSWMLEYGRGVIPLALPYFLFSSIFVTLDIVPWISAVFYVGREVTKNLLIRRKI