lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
ATP-independent protease that degrades both mitochondrial and chloroplastic transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, with a bias for positively charged amino acid residues.
Miscellaneous:
MISCELLANEOUS: The 2 enzymes halves enclose a large proteolytic chamber spacious enough to hold peptide substrates, but sufficiently small to exclude larger, folded proteins. Since the active site includes residues from both the N- and C-terminal part of the protein, proteolysis can occur only when the chamber is closed. Covalently locking the 2 halves of the protease with disulfide bonds induces a loss of activity.
Subcellular Localization:
Plastid, chloroplast stroma. Mitochondrion matrix.
Sequence:
MLRTVSCLASRSSSSLFFRFFRQFPRSYMSLTSSTAALRVPSRNLRRISSPSVAGRRLLLRRGLRIPSAAVRSVNGQFSRLSVRAVATQPAPLYPDVGQDEAEKLGFEKVSEEFISECKSKAILFKHKKTGCEVMSVSNEDENKVFGVVFRTPPKDSTGIPHILEHSVLCGSRKYPVKEPFVELLKGSLHTFLNAFTYPDRTCYPVASTNTKDFYNLVDVYLDAVFFPKCVDDAHTFQQEGWHYELNDPSEDISYKGVVFNEMKGVYSQPDNILGRIAQQALSPENTYGVDSGGDPKDIPNLTFEEFKEFHRQYYHPSNARIWFYGDDDPVHRLRVLSEYLDMFEASPSPNSSKIKFQKLFSEPVRLVEKYPAGRDGDLKKKHMLCVNWLLSEKPLDLQTQLALGFLDHLMLGTPASPLRKILLESGLGEALVSSGLSDELLQPQFGIGLKGVSEENVQKVEELIMDTLKKLAEEGFDNDAVEASMNTIEFSLRENNTGSFPRGLSLMLQSISKWIYDMDPFEPLKYTEPLKALKTRIAEEGSKAVFSPLIEKLILNNSHRVTIEMQPDPEKATQEEVEEKNILEKVKAAMTEEDLAELARATEELKLKQETPDPPEALRCVPSLNLGDIPKEPTYVPTEVGDINGVKVLRHDLFTNDIIYTEVVFDIGSLKHELLPLVPLFCQSLLEMGTKDLTFVQLNQLIGRKTGGISVYPLTSSVRGKDEPCSKIIVRGKSMAGRADDLFNLMNCLLQEVQFTDQQRFKQFVSQSRARMENRLRGSGHGIAAARMDAMLNIAGWMSEQMGGLSYLEFLHTLEKKVDEDWEGISSSLEEIRRSLLARNGCIVNMTADGKSLTNVEKSVAKFLDLLPENPSGGLVTWDGRLPLRNEAIVIPTQVNYVGKAGNIYSTGYELDGSAYVISKHISNTWLWDRVRVSGGAYGGFCDFDSHSGVFSYLSYRDPNLLKTLDIYDGTGDFLRGLDVDQETLTKAIIGTIGDVDSYQLPDAKGYSSLLRHLLGVTDEERQRKREEILTTSLKDFKDFAQAIDVVRDKGVAVAVASAEDIDAANNERSNFFEVKKAL
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVIEMFHNGQPKDEALFPLEIFSIKFSTATIQCCQGAIVRFDSTTLPFAEQKLYQDCRMQTEVYHLNSPQQNGNDSSKRWSLPPPGWVELNTDGAVALNHSWAAAGGVAKRRPWKLATWI
The following text describes a protein:
Function:
Part of the dynein complex of respiratory cilia.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MPTKQRQNVAAVGQIQKPNMPKPSKAASKKKEEDDSTDIGDGVEEWTQAKTLIKPRDQLELTEAELNEEFTRILTANNPHAPQNIVRYSFKERAYKPVSIVEQLAIHFSLDGNMLHKDSDEARRQKLRMGVLEGSTQTDTTAPEPGDNMEAEEHPETPVAGEEGADREDSTKSRKERKLTNQFNYSERASQSLNNPLRERACQTEPPPREVFSATANQWEIYDAYVEELKKQQKLKEKQKAPASKKEEEACSRRRLGATESQSDDLSKLVKSCKIMERMVNQNSFDDVTQDFKYFEDPADEFRGQEGTLMPLWKFQNDKAKGLSVTALCWNPNYKDFFAVGQGSYDFVKQNRGMVQFYSLKNPSFPEYVFSTDTGVMCLDIHREHPYLLAVGLYDGNVAVYNLKANTQLPAFISSAKSGKHTDPVWQVKWQKDDMDNNPNFFSISSDGRVVSWTLVKDELLHSDVIKLSLNGTTASGPEGLKLQIHGSGTAFDFHWQIDYLYLVGTEEGKIHKCSKAYSSKFLDTYDAHNMAVDTVRWNPFHPKVFISCSSDWTVKIWQHDVKTPMFVFDLNAPVADVAWAPFSSTVFAAVTIDGKVHVFDLSVNKYEALCQQAVVAKKKTKLTHVEFNPVYPVLIVGDDRGYVTSLKLSPNLRKIPKEKKGQETQKGPEVEVAKLDKLLSLVREPDTKQGKPESQTHRAEF
The following text describes a protein:
Function:
Blocks voltage-gated potassium channels Kv7.4/KCNQ4 (IC(50)=2.5 uM), Kv7.1/KCNQ1 (IC(50)=2.8 uM), Kv7.2/KCNQ2 (IC(50)=2.7 uM) and Kv7.5/KCNQ5 (IC(50)=2.7 uM). Targets the pore domain, in particular negatively charged residues 'Asp-266' and 'Asp-288', of KCNQ4 and probably other KCNQ channel family members where these residues are conserved. In vivo, shows vasoconstrictive activity resulting in acute hypertension when injected intravenously in mice. Also induces coronary vasospasms ultimately leading to heart failure. Induces seizures when injected into the hippocampus of mice. Decreases respiratory rate while increasing respiratory amplitude, probably by triggering a contraction of the bronchial ring.
Miscellaneous:
MISCELLANEOUS: Negative results: does not inhibit channels TRPV1 and TRPV2, voltage-gated potassium channels Kv2.1/KCNB1 and Kv4.1/KCND1, hERG, tetrodotoxin (TTX)-sensitive and TTX-insensitive sodium channels in DRG neurons or voltage-gated calcium channels in DRG neurons.
Subcellular Localization:
Secreted.
Domain:
Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta). Since the toxin contains only 2 disulfide bonds, it is called 2ds-CSalpha/beta.
Sequence:
MEKKIIFLVFLVALLALPGFISTEVIKKDTPYKKRKFPYKSECLKACATSFTGGDESRIQEGKPGFFKCTCYFTTG
The following text describes a protein:
Function:
ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular Localization:
Nucleus.
Domain:
The DBINO region is involved in binding to DNA.
Sequence:
MDPLSRSSVAPQSCGTSALSPRELAQHLYQMYVLPQRVGPSLAYAASHAPSNETSACPAPEKPQEAKDIQQLFYDRDTWTELYHSIAIQQRELLSRIQLEALDHYGRLSMPPLSRPYDCENLSADVISSCTFEICEYLQGERALAPMEDPFPPINDDTEKFLLTCVHTSLDVMDAPVGTAPVLPTPTYSFDNLLQRPCCIDWSIFYLSSNRAEPYTEVSIADILSLPSNLVSKVPRDTSTIFVDIHRLLFQCIKHASSMLTRSFGLDSSTPPCFRTSTAATLSANEFWSLQVLTDRPQAYLLLVPSTFQSSQFSANIYLCFLSLFFTSYIGLAQLLFERVSDFSNLYTLHSISFFQSPAIEHEDQDMLTSMQFLHLPLLENFSQVFTSYNALLFLLSDTSIQSQILQTNVAVGLTALDSSVLSTLEVMTNEESLLLTLTLCKKLGTNLKNYGGFSQRLLYIDAKERYSQNISALPYPSWVQFCRGSLSWYEDYGLHSITPHACLYPLLTETPSSLISNTGKEFHYDPQLSSYCTKEALSNSTFLQRSIPLKPLRVSTLRHHDTSLKSSRTKRRTVPDVQKRSRSHDQSSDLKDIGNSHSAAWALTDALHQGSALGLNPGTTDGGILTINSLSQLAIGSTTEFKTLYNHTDEYIDSAVTLFDYTNYSFEERLQRNKAFLPPHVITATTIQNRLISYATKHMMKRLRSNKQAFAPGAELARIRRVVKDQISTYKRLLREGRDAYNRDSKIRVKLESKRAEQLQEKHQRERLDFLIRQTEQYTFDNIKSKTGVTLVNTGAEKANLDSTDLFKLKILREDLENEYTDEEEALSKAKDNPRTLNISGLNIDLKKQPTKFIGKLKKYQIIGFSWLVNRFELELNSILSDEMGLGKSVQTIAFFQHLVEKYHYHGPFLIIAPNSLLINWIKELKKFVPSLLLWPYWGTQRERMLIKRGWATTLNFGHNIDTAMEKNESVLGKSDSILHVVITSYQIAVSDIKTLAAIPWKTIVLDEAQLIKSSGTQRWRTIMKYKSRCKVLLSGTPIQNSLEELWALLHFVMPELFERKDDFAEWFSKDIESAASRLGAVKLNADQLRRLQGILAPFVLRRVKGDVEKDLGSKKEIIIKCSMSYHQARLYKTVQQQFSLDTMRSSKDDADIRNIVMQLRKICCHPDLFEHTSSVGPFMLYFFISQSRWCQGTKYLEVMKADMEGDPDDDDDRLSTVTSATGLVAAGQKQQKNLRRVSTSSQTSGLAGVSSLSSIHNGPAAQDAVLPTTSSMPLISGLSDLPGVFQLDGDQISTVDSQSSLVATGADDSLGNSKLLNARRDLIFKRTAQSDVEAFTDIFVKIGIPDIARANYIGRRINPSNACSDIELSLPSPVLLGFCSDLAQKILECTIAKYFNIWNTDVPVLRTISRFLALSVQDLGFLAYCPLLIAHNAAWPALFPMIAHFPFDTKYETRFSIVLHLYSLIGSQLMSFDRSILSSTFSSTLPSILVNPSSLLIVSPMSHLLVSDALENGQSDTSAEHFAIEKTSCVFTNTLSKEYHVRYTQRDLLALHQFKQHWLIKAANDFLESQHLNHLLVYDAIAPKVFGLQPQVHIPTIFKPMHTHDVQALLRGEELYRESTFMGSLITPQSYLPLKLYDQKYVSNSLLNCPVYSKSVLRLIKDSGKLTALDKLLHNLYKTREPVLIYCQMTKMLDLLEDYLVFRRYNYVRLDGGDAVNKRGQIVERFMTDDTIFVFLLSTRAASLGLNLTRASTVIFYENDWNPTQDAQAMDRVHRLGQKKSVVIYRLVTEGSIDEKILEKARSKEIVQELVLRGQRRDEFGNLVHVDAYDNQPSKTNVRRMTRDDYLDLLLPSKGDK
The following text describes a protein:
Function:
Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress. May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MDVLAEANGTFALNLLKTLGKDNSKNVFFSPMSMSCALAMVYMGAKGNTAAQMAQVLSFNKSGSGGDIHQGFQSLLTEVNKTGTQYLLRTANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDFISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLFKVSKNEEKPVQMMFKQSTFKKTYIGEIFTQILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKFVEWTRLDMMDEEEVEVSLPRFKLEESYDMESVLRNLGMTDAFELGKADFSGMSQTDLSLSKVVHKSFVEVNEEGTEAAAATAAIMMMRCARFVPRFCADHPFLFFIQHSKTNGILFCGRFSSP
The following text describes a protein:
Function:
DNA polymerase II participates in chromosomal DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MIKRNMDRSIDRYKVRLVVKGFTLRLGIDFHATFSPVVKPTIIQIVLSMVIHHNWHLCQLDVNNAFLQGNLEKEVYMVQPLGFTNDDKPTHICRMHNNLWLETSPVGMVIASLASKFFIKDLGNLYYFLGVEVIRSSNGLILTQPNYVNENQNDESVTDCNSVPTPMSATELLTLSNGTHLTDATRYRRVLVHHLPTIYCDNLGSTFLSKNPVLHSCVKYAVVDFHFIRHHVDVKKDDSTFKVKYRFRPYFYVATKDKMETDVDSYLRRRYESKIADIEVLEKEDLDFKNHLSGLHRSYLKISFDTVQELMDVKRDLTHIVERNQTKFDTIEAYESILTGKSKQRSQDFIDYITDLREYDVPNHVRFAIDIDVRCGQWYDVGVSSSGVMLEKRTDLLQRAEVHVCAFDIETTKLPLKFPDAEYDSVMMISYMVDGQGYLIINRECVAEDIEDIEYTPKPEYEGHFKVTNVKNEEGLLCHWFAHMQVVKPGIYVTYNGDFFDWPFVETRAALYGLSLKDAVTKAKLGYDPLEVNPEDMVRFAKEKPQMMASYSVSDAVSTYYLYMTYVHPFIFSLATIIPMPPDEVLRKGSGTLCEMLLMVQAYKANVICPNKHQSDPEKFYGSQFLESETYIGGHVECLESGVFRSDIPTSFKLDPSVYELLINNLDRDLQYAIIVEGKMDLESVINYDEVKNAITEKLMSLRDNPLREECPLIYHLDVAGMYPNIILTNRLQPPSIVSDEICTACDFNRPGKKCLRKLEWVWRGEMYMAKRSDYYHIKRQLESELVEGGDCQRSKSFLDLPKAEQVKIKDRLKKYCQKASKRVLEKPVTEVREAGICMRENPFYVDTVRSFRDRRYEYKGLNKVWKGKLSEAEASGNSMKIQEAQDLVVLHDSLQLAHKCILNSIYGYVMCKGARWYSMEMAGVVTYTGAKIIQNALFWTVKLQCRKRCFTVSVSLPHKEHLLHREIPLLATLSNVKTASLASNQVKHATLCGTLTLQICFQGHLRT
The following text describes a protein:
Function:
Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus. Postulated to function in a metabolite repair mechanism by eliminating alternate dipeptide by-products formed during carnosine synthesis.
Sequence:
MRPGEERPVDGGACGGVPALELLKLRAAERIDEAAERLGALSRAIWSEPELAYEEHRAHDVLTRFFEREPPAASWTVQPHYQLATAFRAEWEPPGGRATPRPLQLGFLCEYDALPGLGHACGHNLIAEVGAAAALGVKGALEGRPGPPPPVKVIVLGTPAEEEGGGKIDLMEAGAFKNLDVVFMAHPSQEDAAYLPDVAEHDVTVKYYGKACHAAAYPWEGVNALDAAVLAYNNLSVLRQQMKPSWRVHGIIKSGGVKPNIIPSYSELIYYFRAPSMKELPVLTKKAEDCFRAAALATGCTVEIKGGARDYYNVLPNKSLWKAYVENGKKLGIEFISEDAMLNGFSGSTDFGNVTFVVPGIHPYFYIGSDALNHTEQYTEAAGSQEAQFYTLRTAKALAMTALDVIFKPELLERIKEDFKLKLQEEEFLNTVE
The following text describes a protein:
Function:
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Sequence:
AYKIEETCISCGACAAECPVNAIEQGDTIFVVNADTCIDCGNCANVCPVGAPVAE
The following text describes a protein:
Function:
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity).
Subcellular Localization:
Nucleus. Note=Colocalizes with the PRC2 complex on chromatin.
Domain:
The ARID domain is required to target the PRC2 complex to its target genes; The GSGFP motif is required for the interaction with SUZ12.
Sequence:
MSKERPKRNIIQKKYDDSDGIPWSEERVVRKVLYLSLKEFKNSQKRQHAEGIAGSLKTVNGLLGNDQSKGLGPASEQSENEKDDASQVSSTSNDVSSSDFEEGPSRKRPRLQAQRKFAQSQPNSPSTTPVKIVEPLLPPPATQISDLSKRKPKTEDFLTFLCLRGSPALPNSMVYFGSSQDEEEVEEEDDETEDVKTATNNASSSCQSTPRKGKTHKHVHNGHVFNGSSRSTREKEPVQKHKSKEATPAKEKHSDHRADSRREQASANHPAAAPSTGSSAKGLAATHHHPPLHRSAQDLRKQVSKVNGVTRMSSLGAGVTSAKKMREVRPSPSKTVKYTATVTKGAVTYTKAKRELVKDTKPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASKSTGPAVNGLKVSGRLNPKSCTKEVGGRQLREGLQLREGLRNSKRRLEEAHQAEKPQSPPKKMKGAAGPAEGPGKKAPAERGLLNGHVKKEVPERSLERNRPKRATAGKSTPGRQAHGKADSASCENRSTSQPESVHKPQDSGKAEKGGGKAGWAAMDEIPVLRPSAKEFHDPLIYIESVRAQVEKFGMCRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPNVQRLACIKKHLKSQGITMDELPLIGGCELDLACFFRLINEMGGMQQVTDLKKWNKLADMLRIPRTAQDRLAKLQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGPLEGHTENDHHKFHPLPRFEPKNGLIHGVAPRNGFRSKLKEVGQAQLKTGRRRLFAQEKEVVKEEEEDKGVLNDFHKCIYKGRSVSLTTFYRTARNIMSMCFSKEPAPAEIEQEYWRLVEEKDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTGSILRHLGAVPGVTIPWLNIGMVFSTSCWSRDQNHLPYIDYLHTGADCIWYCIPAEEENKLEDVVHTLLQANGTPGLQMLESNVMISPEVLCKEGIKVHRTVQQSGQFVVCFPGSFVSKVCCGYSVSETVHFATTQWTSMGFETAKEMKRRHIAKPFSMEKLLYQIAQAEAKKENGPTLSTISALLDELRDTELRQRRQLFEAGLHSSARYGSHDGSSTVADGKKKPRKWLQLETSERRCQICQHLCYLSMVVQENENVVFCLECALRHVEKQKSCRGLKLMYRYDEEQIISLVNQICGKVSGKNGSIENCLSKPTPKRGPRKRATVDVPPSRLSASSSSKSASSSS
The following text describes a protein:
Function:
Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.
Subcellular Localization:
Cell membrane, sarcolemma, T-tubule. Endoplasmic reticulum membrane; Single-pass type III membrane protein. Preautophagosomal structure membrane; Single-pass type III membrane protein.
Sequence:
MKKSQPIALDGRDIQSLLDAVGGFGSVVAVGIIAMLSVCAAFFIYRSFRGQRGKTDEINGKETTVATGEESAVRRRRTEKDDRPTESTAECQDAKQKKHRSESSYSSATNNIPLPTEAAEKDLNESTLKDLEEITDELLTDLEPEMGDKTDSDFDPCMEIDPDENTECEEDHIRLKENDDGGCEVVADACVRLTQLDCQIEKTEEFLDKPEGGQSLDTDEPSETESAQDIVYQRRQDTLHNSSSCQSVDHKPSKNHLEEDIKTAEEACKKFEDHHDWRFARTNNFDCCCCDKKMERMKGQPWFPIGSYATDTFTPTVETMVNHCSRFDFQNYLGFQTDNTFIGVSSTQMSLSQEKKANEEGATVEVKHEKNQISIMDAIMDNNEWLNVGAPEFKDRPWLTPNASINEEGKPKADLAKDEEELANKRVATVPPLAQTVSVTFRIHYITHSALQLVAVTGSLQELGAWESFIPLQRAKDGFWANTVSLPVESQVEWKFVLVEDGRISRWEECGNRYLCLTSQDEEVFLEKCWGCC
The following text describes a protein:
Function:
Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt-1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration.
Subcellular Localization:
Perikaryon. Note=Enriched at the ventral edge of HSN cell bodies. This asymmetric distribution is regulated by ced-10/rac1.
Sequence:
MDSCEEECDLEVDSDEEDQLFGEKCISLLSSLLPLSSSTLLSNAINLELDEVERPPPLLNVLEEQQFPKVCANIEEENELEADTEEDIAETADDEESKDPVEKTENFEPSVTMDTYDFPDPYPVQIRARPQVPPKPPIDTVRYSMNNIKESADWQLDELLEELEALETQLNSSNGGDQLLLGVSGIPASSSRENVKSISTLPPPPPALSYHQTPQQPQLLHHHNNHLGYQNGIHQITSINSAASSCSSPDGDSAFGDSSSTESSNNRCRNSAFSSNDSCRDSLNTPSPTQVSPRNGELNAEEAKAQKIRQALEKMKEAKVTKIFVKFFVEDGEALQLLIDERWTVADTLKQLAEKNHIALMEDHCIVEEYPELYIKRVYEDHEKVVENIQMWVQDSPNKLYFMRRPDKYAFISRPELYLLTPKTSDHMEIPSGDQWTIDVKQKFVSEYFHREPVVPPEMEGFLYLKSDGRKSWKKHYFVLRPSGLYYAPKSKKPTTKDLTCLMNLHSNQVYTGIGWEKKYKSPTPWCISIKLTALQMKRSQFIKYICAEDEMTFKKWLVALRIAKNGAELLENYERACQIRRETLGPASSMSAASSSTAISEVPHSLSHHQRTPSVASSIQLSSHMMNNPTHPLSVNVRNQSPASFSVNSCQQSHPSRTSAKLEIQYDEQPTGTIKRAPLDVLRRVSRASTSSPTIPQEESDSDEEFPAPPPVASVMRMPPPVTPPKPCTPLTSKKAPPPPPKRSDTTKLQSASPMAPAKNDLEAALARRREKMATMEC
The following text describes a protein:
Function:
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Sequence:
MASNIAFYNTDYAIVEAELRSNPQGFVANAEYLSLAQLQTPEEFCSALATITGISIPTIASSSDIRCGLLNKLAETFRDLLPSAEGLLLQFLLLLRTQYVLSNSFILISAALKGRAADSSIRFHPIGVFQNLELLVSIENLSEIVGTLLEASPAGPFLIKAGLDVESVQLESMSQQDIEILRAKAESLYLEHLLNFSLSIGGQTAQTMNDLLYFEADRMTIMLVFNLLGNENFTPEAKMEIMPRLGALYPYHQERLSQCSDMDSVRSIISEFQEYKKVLDRMSADSSLTLLDAFMFEQVDSLRDGFKSQYDFASIYCYFKLKELEMNNLVWMYEALQQNQLSEMRKYVPVI
The following text describes a protein:
Function:
Binds to Rho-kinase Rok and targets it to the apical cell cortex where it mediates apical constriction. During embryogenic axis elongation, required for the localization to adherens junctions and the establishment of planar polarization of both Rho-kinase Rok and myosin regulatory light chain sqh. May be involved in the assembly of microtubule arrays during cell elongation (By similarity).
Subcellular Localization:
[Isoform D]: Cell junction, adherens junction. Cytoplasm, cytoskeleton. Note=In adherens junctions, enriched in discrete spots and in tricellular junctions. In adherens junctions, localization requires Rho1 GTPase activity and interaction with the F-actin cytoskeleton; [Isoform F]: Apical cell membrane; Peripheral membrane protein. Note=Localization to the apical cell membrane depends on N-terminal region. Excluded from the lateral membrane.
Domain:
The ASD2 domain mediates the interaction with Rok and is required for apical constriction induction.
Sequence:
MKMRNHKENGNGSEMGESTKSLAKMEPENNNKISVVSVSKLLLKDSNGANSRSSNSNASFSSASVAGSVQDDLPHHNSSSSQLGQQHGSSLDQCGLTQAGLEEYNNRSSSYYDQTAFHHQKQPSYAQSEGYHSYVSSSDSTSATPFLDKLRQESDLLSRQSHHWSENDLSSVCSNSVAPSPIPLLARQSHSHSHSHAHSHSNSHGHSHGHAHSASSSSSSNNNSNGSATNNNNNNSSESTSSTETLKWLGSMSDISEASHATGYSAISESVSSSQRIVHSSRVPTPKRHHSESVLYLHNNEEQGDSSPTASNSSQMMISEEANGEESPPSVQPLRIQHRHSPSYPPVHTSMVLHHFQQQQQQQQDYQHPSRHHTNQSTLSTQSSLLELASPTEKPRSLMGQSHSMGDLQQKNPHQNPMLGRSAGQQHKSSISVTISSSEAVVTIAPQPPAGKPSKLQLSLGKSEALSCSTPNMGEQSPTNSIDSYRSNHRLFPVSTYTEPVHSNTSQYVQHPKPQFSSGLHKSAKLPVITPAGATVQPTWHSVAERINDFERSQLGEPPKFAYLEPTKTHRLSNPALKALQKNAVQSYVERQQQQQKEEQQLLRPHSQSYQACHVERKSLPNNLSPIMVGLPTGSNSASTRDCSSPTPPPPPRRSGSLLPNLLRRSSSASDYAEFRELHQAQGQVKGPSIRNISNAEKISFNDCGMPPPPPPPRGRLAVPTRRTSSATEYAPMRDKLLLQQAAALAHQQHHPQQHRHAQPPHVPPERPPKHPNLRVPSPELPPPPQSELDISYTFDEPLPPPPPPEVLQPRPPPSPNRRNCFAGASTRRTTYEAPPPTAIVAAKVPPLVPKKPTSLQHKHLANGGGGSRKRPHHATPQPILENVASPVAPPPPLLPRARSTAHDNVIASNLESNQQKRSNSKASYLPRQSLEKLNNTDPDHGIYKLTLTSNEDLVAHTKPSYGVTGKLPNNLPDVLPLGVKLHQQPKLQPGSPNGDANVTLRYGSNNNLTGNSPTVAPPPYYGGGQRYSTPVLGQGYGKSSKPVTPQQYTRSQSYDVKHTSAVTMPTMSQSHVDLKQAAHDLETTLEEVLPTATPTPTPTPTPTPPRLSPASSHSDCSLSTSSLECTINPIATPIPKPEAHIFRAEVISTTLNTNPLTTPPKPAMNRQESLRENIEKITQLQSVLMSAHLCDASLLGGYTTPLITSPTASFANEPLMTPPLPPSPPPPLEPEEEEEQEENDVHDKQPEIEELQLMQRSELVLMVNPKPSTTDMACQTDELEDRDTDLEAAREEHQTRTTLQPRQRQPIELDYEQMSRELVKLLPPGDKIADILTPKICKPTSQYVSNLYNPDVPLRLAKRDVGTSTLMRMKSITSSAEIRVVSVELQLAEPSEEPTNLIKQKMDELIKHLNQKIVSLKREQQTISEECSANDRLGQDLFAKLAEKVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSLETRQQERGALESKRDLLYEQMEEAQRLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQLSSLSDALVQSDC
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.
Subcellular Localization:
Mitochondrion.
Sequence:
MAPGSKPAPAVGVVDYRYNERNVFSLMLQGASGGLETPIIFDSTHTFALLDKFPLARGHSLLVVKAPVATLLEDLKPEVAAAAFADLQALCRALVAATGCAGLRVTQASGPAAGQTVPQLHFHIVPVYTNNNNNNTNADSGTASAAPSASATAGAGEAAADANAATAASATAASAPAVAAPAADAGGGLRSQLLPGEAGPLLAALRNRLPATYAPGYHAWAGDEGEMEGLGAALHQAFGQPGSIIGLSGQLGAGKSTISRGFVRAFARDPLLAVPSPTFLLCLSYADDTAHERREAAVGGEAVAAVGEAVGVAVGEVVETVGGGEAAAAGCGAGVEGGVGAGTAAVPMEAPASGSGSGSGSGSGVPEQQQQQQQQQQQPLRSDRAGSVHHMDPYRLGGGSKSDKMAGLIDFASAFSKDVCLIEWPDRMPGSVMALSAGGLAVDVSGMGAQASGRLVTLTPMGNRFHPPPPKGRVAKEAAAAAAEAAAAAEAAAKAAAEAAAGASGAAQEPPAAPLGVEANERAARVIEEWRRTYPSGRLPTPAVAWRRGGGGGGGAGLNDGLVGAGGGGGAATTINATAAAALAGGAAAAAGWVVLGIESSCDDTAAAVVRGDGTVLSHVMASQTGLHEQYGGVKPDVARQAHAAAIEATVDGALAAAGLRPEQLTAVAVTAGPGLALCLQVGVQHGLRLAAAHGLPFVPCHHMEAHALMTRLPSVNEAPMQFPSLLLLFPSLLLLVSGGHNLLVLCEGVGRHRILGTTLDDSVGECFDKIARMAGITAVPGGPHLERLAATARPDALSRYPLTMPLANGAQRDSCNFSFSGLKTQVATLIAARRKELQLPDLPLPPAIAAERAAAKTAAAAAAAATGAAAAAAAAAAEEGENDDGGENGSASATATEAAAAGKAGEKEAGQQGQEGEEVISEEERQRRAEGEAAFMQTCADLAASFQRTAVKFLQQRTRRALQWLREDAEQLGALAPPGARAGPGSSSIGIGSSTTAAAGGGSSTTGGAAAAGAGSSNSGGGGGGGGAPGGFVRSLVVAGGVAANAAVRAGLAEVAAEFGLPCVYPPVKYCTDNGLMVAWTGVERLRLGLYSQPPAPADAEGDKLDAQVQVIPRWPIGPMDPRSTANKGRAHIKLLH
The following text describes a protein:
Function:
Thiol protease. Acts synergistically with RgpA to catalyze the maturation of fimbrial subunits, such as FimA (By similarity). Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defense mechanisms (Probable).
Subcellular Localization:
Secreted.
Sequence:
MKKNFSRIVSIVAFSSLLGGMAFAQPAERGRNPQVRLLSAEQSMSKVQFRMDNLQFTGVQTSKGVAQVPTFTEGVNISEKGTPILPILSRSLAVSETRAMKVEVVSSKFIEKKDVLIAPSKGVISRAENPDQIPYVYGQSYNEDKFFPGEIATLSDPFILRDVRGQVVNFAPLQYNPVTKTLRIYTEIVVAVSETAEAGQNTISLVKNSTFTGFEDIYKSVFMNYEATRYTPVEEKENGRMIVIVPKKYEEDIEDFVDWKNQRGLRTEVKVAEDIASPVTANAIQQFVKQEYEKEGNDLTYVLLVGDHKDIPAKITPGIKSDQVYGQIVGNDHYNEVFIGRFSCESKEDLKTQIDRTIHYERNITTEDKWLGQALCIASAEGGPSADNGESDIQHENIIANLLTQYGYTKIIKCYDPGVTPKNIIDAFNGGISLANYTGHGSETAWGTSHFGTTHVKQLTNSNQLPFIFDVACVNGDFLYNVPCFAEALMRAQKDGKPTGTVAIIASTINQSWASPMRGQDEMNEILCEKHPNNIKRTFGGVTMNGMFAMVEKYKKDGEKMLDTWTVFGDPSLLVRTLVPTKMQVTAPANISASAQTFEVACDYNGAIATLSDDGDMVGTAIVKDGKAIIKLNESIADETNLTLTVVGYNKVTVIKDVKVEGTSIADVANDKPYTVAVSGKTITVESPAAGLTIFDMNGRRVATAKNRMVFEAQNGVYAVRIATEGKTYTEKVIVK
The following text describes a protein:
Function:
Plays a role in cell adhesion. May play a role in cell-collagen interactions (By similarity).
Subcellular Localization:
Secreted. Secreted, extracellular space, extracellular matrix. Note=May be associated both with microfibrils and with the cell surface.
Sequence:
MALLMRLLTLALALSVGPAGTLAGPAKSPYQLVLQHSRLRGRQHGPNVCAVQKVIGTNKKYFTNCKQWYQRKICGKSTVISYECCPGYEKVPGEKGCPAALPLSNLYETMGVVGSTTTQLYTDRTEKLRPEMEGPGSFTIFAPSNEAWSSLPAEVLDSLVSNVNIELLNALRYHMVDRRVLTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVISTITNNIQQIIEIEDTFETLRAAVAASGLNTVLEGDGQFTLLAPTNEAFEKIPAETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGMSMETLGGTTLEVGCSGDKLTINGKAVISNKDILATNGVIHFIDELLIPDSAKTLLELAGESDVSTAIDILKQAGLDTHLSGKEQLTFLAPLNSVFKDGVPRIDAQMKTLLLNHMVKEQLASKYLYSGQTLDTLGGKKLRVFVYRNSLCIENSCIAAHDKRGRFGTLFTMDRMLTPPMGTVMDVLKGDNRFSMLVAAIQSAGLMEILNREGVYTVFAPTNEAFQAMPPEELNKLLANAKELTNILKYHIGDEILVSGGIGALVRLKSLQGDKLEVSSKNNVVSVNKEPVAETDIMATNGVVYAINTVLQPPANRPQERGDELADSALEIFKQASAYSRAAQRSVRLAPVYQRLLERMKH
The following text describes a protein:
Function:
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Sequence:
MADAATKAEQHVWVKSMDMPDDAIKIKGFDFNKGVKLDEVVKHFLTTGFQASNFGMAIEQINKMREHRSKPVNLSPEEEKLDPIYRPRSDCTIFLGYTSNMVSSGIRETIRFLAQHRMIDCIVTTAGGIEEDFIKCFAPTYLGDFSLKGKDLRPKVCEQKQHGTLWTPSKLIARLGKEIDNEESIYYWCYKNEIPVFSPAITDGSIGDLLFLHAYRNPGLVLDIVEDIKMMNSIAAHSKHSGMIILGGGLPKHHIHNANFMKGGADYGVFINTAQEFDGSDGGARPDEAVSWGKIKSSATPVKIFADATLVFPLLVSQTFAKDFKSDSNGQER
The following text describes a protein:
Function:
Specifically methylates guanosine-37 in various tRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MKFNFITLFPDKIQSYFSEGLQQKAIESGVFSVNIIQLRNFSGNKHNRVDDTIYGGGPGMLLRVEPIHKAILSLGEEKGIVILTSPSGIPFNQSIAMDLKKGGKPLTFISGYYEGVDHRVTEHLVDMEMSLGNYVLSAGDLASICIADAVSRLLPGFLGADESLLDESHNHPDILEYPQFTKPSEYNGWKVPDVLLSGNHASILAWREQNRKKIERGNYESTFKRSADSGC
The following text describes a protein:
Function:
Inhibits soybean trypsin. Has antifungal activity against R.cerealis, A.brassicae and A.niger, and weak antifungal activity against F.oxysporum.
Sequence:
EWEPVQNGGSSYYMVPRIWA