lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.
Subcellular Localization:
Cytoplasm.
Sequence:
MGSLSVSHCTTWIRFPSLYFIFSLSPLSPPLPLAPQLHAFPPPSPTICKPGLERRVQHTDSTDPGAFAIFLVVFPVAEKKGGCVFFFFFSPLLSFSSPLEPTHQMYLKCKYEPPEETLQYKTETHVRAGKKNAKRRAKKKKKKKKLQRGRGCKVRWCTDSSIFRTGRLQEGRKIHPSSLLLRFCQGEIPFATILQEERLREGPRRSVWTPCAMASSQLPPCPTVGTVLASQPPSELPPGEEDLGEAFDFEDSDEEDEDSATEPSRGAVLQAPPRRHRATSSSTEGLVPEIQEGLPERVSNGETCEDPSDINSQTWKRKSGCRGDRFEFTAAEDDVIYDDVPCENLDANQDGRSLIYEDVQRGEELGWSSSEFESYSEESGEENKPEAEPAKHRASFQPKMTQLMKAAKSGTKDGLEKTKIAVMRKVTFLHRKEVPGDSEEEDTGFLEVTVSDMKHPPPELGPMPTGLSPQQVVRRHILGSIVQSERNYVESLKRILQDYRNPLMEMEPKVLSARKCQVVFFRLKEILQCHSMFQIALSSRVAEWDSAEKIGDLFVASFSKSMVLDVYSDYVNNFTTAMSLIKKACLTKPAFLDFLKKRQMASTDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPKGHADRLSLQLALTELETLAEKLNEQKRVADQVAEIQQLSKSISDRSSLSKLLNSGQRQLLLCETLTETVYGDRGQLIKSKERKVFLLNDMLVCANINFKGQLEISSLVPLGPKYVVKWSTALPQVQVVEVGQESGAYDKDNVVIHNAGAKKHAPTGPASHNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRMMKVKEEEIHSANKCRLRLLLPGKPDKSGRPISVMVVFITPNPLSKISWVNCLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILSCHMPAFSSKALDLQLSAAVHNPVQSSLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRSVPRTVKSFPVASPVLCMEYIPEVAEGDTVGTEEPRAGAEQPPATLHPTVCLGLQDGSIAVYGSVDTGTQCLLTCKSPGMQPVLCLKHSPEYLFAGLQDGTVAAYPRSNGGLWDLTEQPTRLPVGTGPVRALLMLDETLWASCANQVTVLDASTLCAQQTFEAHPDTEASVTHMIKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFVLPGQRHVRVTSLLICQGLLWVGTDQGIIVLLPVPRLEGIPKITGKGMVSLNGHGGPVDFLAVALSTLAPDVLKGDQEEEEGEEEKPPELDGPPPREIRKKGILLQYRLRSTSHLPGQLLSVRDAPVGTVTPEHTEEDGSIYEMADDPDVWVRSRPCARDAPRKEISSVAIISGGRGYRNFNSEPQRRGGDADSTLLIWQLPLML
The following text describes a protein:
Function:
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MEATLSLEPAGRSCWDEPLSITVRGLVPEQPVTLRAALRDEKGALFRARALYRADAHGELDLARAPALGGSFTGLEPMGLIWAMEPERPFWRLVKRDVQTPFVVELEVLDGHEPDGGRLLARAVHERHFMAPGVRRVPVREGRVRATLFLPPEPGPFPGIIDLFGVGGGLLEYRASLLAGKGFAVMALAYYNYDDLPKTMETMRIEYFEEAVNYLRGHPEVKGPGIGLLGISKGGELGLAMASFLKGITAAVVINGSVAAVGNTICYKDETIPPVTILRNQVKMTKDGLKDVVDALQSPLVEQKSFIPVERSDTTFLFLVGQDDHNWKSEFYANEISKRLQAHGKEKPQIICYPEAGHYIEPPYFPLCSAGMHLLVGANITFGGEPKPHSVAQLDAWQQLQTFFHKQLGGKSHGVSPKI
The following text describes a protein:
Function:
Part of the ABC transporter complex FecBCDE involved in citrate-dependent Fe(3+) uptake. Probably responsible for the translocation of the substrate across the membrane (Probable).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKIALVIFITLALAGCALLSLHMGVIPVPWRALLTDWQAGHEHYYVLMEYRLPRLLLALFVGAALAVAGVLIQGIVRNPLASPDILGVNHAASLASVGALLLMPSLPVMVLPLLAFAGGMAGLILLKMLAKTHQPMKLALTGVALSACWASLTDYLMLSRPQDVNNALLWLTGSLWGRDWSFVKIAIPLMILFLPLSLSFCRDLDLLALGDARATTLGVSVPHTRFWALLLAVAMTSTGVAACGPISFIGLVVPHMMRSITGGRHRRLLPVSALTGALLLVVADLLARIIHPPLELPVGVLTAIIGAPWFVWLLVRMR
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.
Subcellular Localization:
Nucleus.
Sequence:
MHGHSPGSAILVNAEVDSMGGVIDGGVGIDNKTSPRQAAIEKAQAELRQEYDVREERRRELEFLEKGGNPLDFKLGPATSFSVQSTSFTDQLAEQFVTSEAKGSFALAASPHGDSVESSGRPGAPSGREQNSADNLLLFDGENDLVESERNSVNPSRRNNVAPSEQSSQLDGNHNAKESEDSSILRFVVKSQAYARRNRSKTSRDASRACSTDLVQGGDGNVSSSLPSRHGSRDAKVSICETKSQKDHNSASSICNSKSTNPNGNGVFKTLASDNQLDMELDPVKVNKTATKTCLADGGHDVKALKDLQDGRHNQNLLVDNEKVPNTMVLKTSDLVGDKDGASAAPDCIPSEAAGKTEKFTSTGELNGFSVPNMDGKDMQNEGQNGSAALGTKALDSESSCSQISPSLNGDTTTDQSLNLKVNSNGNSKEQTLVAQYPGIADVDLVKQNNETNAVDASAVSNDELNCVHKNLSSNGSQVKLEEEMSICRSVLENEEKLANQKSEEKLVSQKSEEKLINQKNDEKLLTNVEGLEPNDQNHLKTDKKNLSIDNSYSKKTGSYPQGRPSSTKASSSYEPPEATFSGRGPSAASELQTFTGNHLKLATKAHEDSILEEARTIEAKRKRIAELSVGNVPLENRRKSHWDFVLEEMAWLANDFMQERLWKTTVAAQIGHWVAVSGRLRFGEKVLCQKQRKLANILAKAILQFWHSAMVILNGEDSKVGLKEGKEVLVGSQEVNADEAVMNKTGQPNKMQDTDKQLEEKNPGQDLQLPVQGYAVRFLKYNDSLNHQFQAEAPATPDRISDLGIQEMSWEDQFSEESLFYTVPPGAMENYRKSVESYWAEYEKTGSGAQQEEIEAPTDDGVSEFGSRDNAYEEDEGETGAYYLPCAFEGSKSSKFAQKRHKSLQKSYSARSYDLGADLSYGQCMENKPATQSSLLTGKRPTNSLNVGSIPIKRMRTASRQRVVCPFGGGATGSAQAANKTDVSSGDTSSFQDDQSTLHGGSQFRKTSEVESTGDFGKPLSYDCTEISKPKKKKKTKHLLYKSSLNSTDTGSFVMPGKGAAYEQRWQLDSIVQNEQRDTSKKRLEGHHFEPNGNSGLFGQPAAKKPKIMKQLTDTSPESFTPMSGSIPSPVASQMSNMSNPNKLIKMIAGRDRGRKTKALKTPNGQSGSGSPWSLFEDQALVVLVHDMGPNWELVSDAINSTLQFKCIYRKPKECKERHKILMDRNAGDGADSAEDSGSSQPYPSTLPGIPKGSARQLFQRLQGPMEEDTLKAHFEKIIALGQQLHSHRSQNDNQDLKQIAPVHNSHVIALSQVCPNNLNGSPLTPLDLCNESTSSADVLSLGYQGSHTSGLAIPNQGSVAPGLPSSSGNTILQGSSGMVLGNGLPSPSAGLNVPSRDGQRYGTSRPGSLSIDEQQRMQQYNQMLSGRNIQQSGLSVAGTLPGTDRGVRMLPGGNGMGMMMNRGMQVPRPGFQGMGSPAMLNSGNMLPSSGVGMPSPVNMHTGAVSSQGSSMLRPRDAMHLMRPGQNPEDQRQMMMQELQMQVSQGNSQGVPPFSGMSTAFSNQTVPPPVQSFPVQHQQQHQMPQQSHMLSNPHHSHLQGSNHATSPQQQAYMLRVAKERQLQQRFLQQQQQQQHPHQHQFSASNNLIPHAQSQSQHPISSPMQNNSQIQQQVSSQPVPLPTSNSQHPLTPSSPMNPMPSQPQQKQHHLQSHGQSRNPQASGGNLQGQMLKQRQQRQQQLQQAGRHHPQQRQQSQAQPQAKLMKGLGRGNMMMHHNLAIDPSHINGLSTPPGSHVGEKEQVMHLMQGQGLFPNSGSNSIQSGKPLLPSQSSNQCQPQQKLFSRPSPSFSKQLSPMPSLPDNSNQSQVPGVPSGHILGSQQAVPQLAMTSPHQQQQPQPQTQQRQAGQSPHSIQRMLPPTRPVNSDPPMQSLGDHVQVGQQPLSGSFHMGINTTVPQSCAESTSGIPVVSSANAAQWKAPEPSYDSATTNQATNLAATIGNPSLQNPVGTEPIPSASPGLAQRQFSGSIPIPGHNSGTQWQPQPQSQQLSSSPSPPPPPQQQTQQQRQQQSQHQQQQQQQSQHQQQQQPPPPPPPPQQQQPPQQQQHLQAGQAGLYPRPTDSGPG
The following text describes a protein:
Function:
May act as a GTPase regulator. Controls survival and growth of spinal motoneurons.
Sequence:
MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVVTVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQSVATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVREDSEHGEKPMPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKKVMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTVPRLAKISSENGVWSVAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPLLSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLDSYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLPIRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFPGKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLWAEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSGSSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKITGTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDNIAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPLHPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTIPLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDREEDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQQISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSEVHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN
The following text describes a protein:
Function:
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Sequence:
MVKLAKAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEEDDSEEDEDDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDEDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDDDDDDEDDEDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE
The following text describes a protein:
Function:
Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
Subcellular Localization:
Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle.
Sequence:
MWEELQSGGGPEKTQAGPHGRKTILLQSVRKKLQPGRKSEKTQEDPHWREFKVTADMEGAAEGIYEHAGAGAALSAHLPNQEAALLSRRRNCSPFVAEDFWIRVCATHNVAMKIDEKALGYFQSCDSPVDKEGYLYKKGEIKTSYQKRWFVLKGNLLFYKERSADRDVSGVIVLEGCTVQLCESEEQFAFSLVWSEPGLRTYKFAAEDQASQESWIKALLSANHSYLALLVQDMENKYKDTLAELSGKPNQPSTAPNLRADAQYSAAVLSTRVSTLSVLPPQAAGAGLSPLVPSSATLPSKRSPKLWPKKSTNMVSHSTPAMSTADWVDYSSGPVEDFQTLHEEFGKEVKKLITVWAKRTGLDQNVEDDLINFE
The following text describes a protein:
Function:
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
Sequence:
MKNLVVVDHPLIKHKLTIMRDKNTGPKEFRELLREITLLLAYEATRHLKCEEVEVETPITKTIGYRINDKDIVVVPILRAGLVMADGILELLPNASVGHIGIYRDPETLQAVEYYAKLPPLNDDKEVFLLDPMLATGVSSIKAIEILKENGAKKITLVALIAAPEGVEAVEKKYEDVKIYVAALDERLNDHGYIIPGLGDAGDRLFRTK
The following text describes a protein:
Function:
FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MNRLFCTTLVKYSPRNAILPSRAVQWPRTLATTASNRHANTESTTSDAQHYDIIIVGGGMVGTALACALGKNSRLQNKNILLLEAAAGFKQPSTEQYSNRVSAISKGTYRLMRTIGAWEEIERTRVKPVLKMQVWDACSDALITFNYDDFAENISWIVENDVLLASIYRQLEGVPNVRVRYSSKLASCELIRDGADRSTVRLADGETLKCDLLVGADGYNSLVRRQMGVQNFALAYNQMGVVATLRLANAPSDNVTAWQRFLPTGPIALLPLSDDTSSLVWSTGVAEAKRLLQLDGDSFIAAVNAAFHKPMPRNTLVDDVMKGVHSLIKQTTGQRLEAAPVVEAEVASSRAAFPLGLGHTSTYVGQGVCLIGDAAHRVHPLAGQGVNLGFGDVQTLVDVLADANYAGLGISNVSELLKYEQQRLKHNVPVLLTTHSLQRLYTTDFVPTVALRSIGLTLTNALPPVKVLILG
The following text describes a protein:
Function:
Involved in CpXpG DNA methylation.
Subcellular Localization:
Nucleus.
Sequence:
METPPPDPVSPPPPAADEGSPGGDDGAEDAGGFSAGLDSLWTALFGSPEELEPMWSPPRGFGVGAEFAAAEVEPEIMDVAGGPWDGAPWRSSGVVAGEGAATALVPPTAAAGFAEFEPAAPIDSYPAGAAAASLGDVPEVSALDSGVDCSPDPPPSSSPPVDFDARGFDPVADSAPAMESPLPPSVASSEANLDGRMLDCTLNSVPSPPLASPYEVGLGAEDPIKDSSPSVAWGTTMDAKDPEVDATCANGTALRRSRRIMKIKSAASSMPLNQNGDSSRASKRRVADSRKSRSSEGSKLPAFTGPISVNTVDLINGVKVQGLQEIVAVENVSSSYDNNQKAGGLYNQVVVALPAASNSLLKDKGASVLPRRKTRLASKVLVNSDRVSAISPVVNGGPPVQKSDVCIPTKKHKLAVEECLTSLDGVDGGGIVLCNSKLKSAKSRVVSKTPQGRGRRSPQPPKTQRARTLSVKYLEKLKRAENNNNNGSMSKSPRVPMIPENNGSMSKSPRVPIIPELSTKHELVLDKHMVDSVMLETDDGSCFFVGDAVPDDEARKQWPHRYEINDQIMKKDKRTSSQTFANAGKAVLDVKCHYLQAKVSRYTFCIGECAFVKGPEGKPNYIGRLLEFFETKTGECYFRVQWFFTAEDTVIGEQAQSHDPRRLFYSDLTDDNLLDCIVSKVTIVQVPPSVDGKSKSVPSSDYYYDMKYSIDYSTFSTIEMEDTDDLMQSCYTSRINDKMKKIDVNKKHKSPVLEKMELSLLDLYCGCGGMSTGLCLGARGGGVNLSARWAIDDDEIACESFRNNHPETRVRNETTDDFLELLKEWEKLCKTYVKHSRTKACVDSTTESNNETPDCSTVPPEEFEVWKLVDICFGDPNKVSKHGLYFKVRWKGYGPHHDTWEPVEGLRNCKEAIRDFVIEGHRQRILPRPGDVDVVCGGPPCQGISGYNRNREFEAPFKCEKNKQIIVFMDVVQFLKPKYVYMENVLDILKFADATLARYALSRLVAMHYQARLGIMAAGCYGLPQFRMRVFLLGCHSKEKLPPFPLPTHEAIVKNGCPLAFERNLVGWPNDTPMQLARPIVLEDILSDLPEVANGESRDEMLYVKGPQTEFQRYIRSFNVEVHGPRAHVTKDSKSSKLYDHRPLVLDNDNYQRILQIPKRKGANFRDLSGVIVGPDNVARLDPTKERVLLPSGRPLVLDCILAYENGKSLRPFGRVWWDEVVGTVLTVPNARMQALIHPAQDRLLTIRESARLQGFPDNYRFRGTVKDRYRQIGNAVAVPVGRALGYALAMAYLKKSGDDPLMLLPPNFAFSHDLRGFA
The following text describes a protein:
Function:
JanA and janB regulate somatic sex differentiation.
Sequence:
MNITQQSEETHQSEEINQSEQINQSEEINQSKEINQSEEIQQSEETRQSEQEAFIKITKNVSQVGLDDEGTFKYILILLTGNNNQEFYFVRGLKKYGYHAQNFEHFCNEVKNNLKWSDFNFDLEEGKIKLQLDGHKFKFKCLGGGRIKHSFIGQSIEIYGYSWLYGQCDHKISLNAIRTVYPYLDSNVITRNDGY
The following text describes a protein:
Function:
Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MAAEVEAEPELPEEVVDSMESFHESLGNIEDALKPLLENSTDDMKESMGPLQLAKLNLVVAYSINSLFWMYLITQGMDPKEHPIKQELDRIKKYMVKVKEVQHKQEVSMRIDKGAAKRFVKSALWQPTSNEDKGKDDSKTSTKELTIKNGVLTGCRILRTEVHGADGYN
The following text describes a protein:
Function:
Catalyzes the exchange of L-carnitine for gamma-butyrobetaine. Can also transport D-carnitine and, with lower efficiency, acetyl-L-carnitine and glycine betaine.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
Contains two carnitine binding sites, a primary binding site at the center of the protein and a secondary binding site at the bottom of the intracellular vestibule. Contains two gamma-butyrobetaine binding sites, one in the central transport site, the other in an extracellular binding pocket. Binding of both butyrobetaine molecules is cooperative, indicating that the extracellular site is regulatory. The occupied regulatory site may increase the binding affinity of the transport site and initiates substrate translocation. Both L-carnitine and gamma-butyrobetaine are able to dissociate completely from their primary site into the cytoplasm. Substrate molecules initially located at the secondary sites dissociate even faster into the extra- or intracellular regions.
Sequence:
MKNEKRKTGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLGNEPPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFGLEPNSTGAKELGLAYSLFHWGPLPWATYSFLSVAFAYFFFVRKMEVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWIILNAICVACGLQKGVRIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMYLPRMLFYTDPIAKGGFPQGWTVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVLGLTASTWILWTVLGSNTLLLIDKNIINIPNLIEQYGVARAIIETWAALPLSTATMWGFFILCFIATVTLVNACSYTLAMSTCREVRDGEEPPLLVRIGWSILVGIIGIVLLALGGLKPIQTAIIAGGCPLFFVNIMVTLSFIKDAKQNWKD
The following text describes a protein:
Function:
Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins; [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein; [Isoform 2]: Secreted.
Sequence:
MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT
The following text describes a protein:
Function:
Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules. Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to microtubule plus ends. Associates with centrosomes during interphase, but dissociates from these structures from the onset of mitosis.
Sequence:
MDQPAGGTGKLRASAGEDDSMELSTCQELLHRLRELEAENSALAQANENQRETYERCLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQVLSALLQQKLQLTANSLPQIPLTPLQPPSERPTSPAPNVSEGPATSLPSGLCAGQREVCWEQQLRPGGPGPPATPPPALDALSPFLRKKAQILEVLRALEETDPLLLCSPATPWRPTGQGPGSPEPINGEPCGPPQPEPSPWAPYLLLGPGSLGALLHWERVLGGPGEEEGIRQPWASSRAPPSAQGPSSGPHCAPGSSSSSSSDEAGDPNEAPSPDTLLGALARKQLNLGQLLGDTETYLQAFLAGATGPLSGDQPGPGKPNSPDPGPPQVSKSKGLPKSAWGASTPEATRLGFGATSEGQGPLPFLSMFMGAGDAPLGSRPGHPHSSSQVKSKLQIGPPSPGDAQGPLLPSPARGLKFLKLPPASEKVPSPGGPQLSPQLPRSSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGAQGLPGSPLPCSAMPDSAQLRPSQSTVSTALSPGPVVSPCFENILDLSRSTFRGSPPEPPPSPLQVPTYPQLTLEVPQTPEVLRSPGAPSPGLPESCPYSGPQEKSMDRAGSESPHASRRTPGGSSKKPGQGSGRRPGDPSHTPLRDRLAALGKLKTGPEGPLGPEKNGVPARSSAEKARALVRSGECAGDVPPSARPLEQPEAKGIFRGAVALGTSSLKQQEPGLTDPGARVYSSHSMGARVDLEPISPRSCLTKVELAKSRLAGALCPQMPRTPAKVPTSAPSLGKPKSPHSSPTKLPSKSPTKVVPRPVVPLGTKEPPKPDKVKGPPWADCGSTVGQPTSPVAGPADPSQGSEGPAPHSAIEEKVMKGIEENVLRLQGQERTPGSEAKHRNTSSIASWFGLKKSKLPALNRRTEATKNKDGAGGGSPLRKEVKTEARKLEAESLNISKLMAKAEDLRRALEEEKAYLSRARPRPGGPATVPSPGLGQAQGQLAGMYQGADTFMQQLLNRVDGKELPPKSWREPKPEYGDFQPVSTDPKSPWPACGPRNGLVGPLQGCGKPGKPSSEPGRREEMPSEDSLAEPVSTTHFTACGSLTRTLDSGIGTFPPPDHSSSGTPSKNLPKTKSLRLDPPPGAPPARPPGLTKVPRRAHTLEREVPGIEELLVSGRHPSMPAFPGLLTAPPGHRSHQTCPDDPCEDPGPPPPVQLAKNWTFPNTRTAGSSSDPFLCPPRQLEGLPRTPMALPVDRKQSVDPSRTSTPQGPAFGGSRTPSTSDMGEEGRVASGGAPGLETSESLSDSLYDSLSSCGSQG
The following text describes a protein:
Function:
Probable GTPase-activating protein (By similarity). Regulator of membrane trafficking. Required for maintaining a straight growth of root hairs.
Subcellular Localization:
Endosome.
Sequence:
MHFAKLDDSPMFRQQMQSMEESAELLRLRCLRFYKGCRKYTEGLGEGYDADIGFVNALESFGGGHNDPVCVAFGGPVMTKFTIALREIGTYKEVLRSQVEHMLSDRLLQFVNGDVHEVKEARKRFDKATITYDQAREKYLSLRKSTRLDVAATIEEDLHSARTTFEQARFHLVSALSNAESKKRFEFLEAVSGTMDAHLRFFKQGYELLHQMEPFINQVLAYAHQSRECANYEMASLNERMQEYQRQVDRETRNSCVSPTGDGMRHNSRNSQKVIEAVMQSAAKGKVQTIRQGYLSKRSSNLRGDWKRRFFILDSRGMLYYYRKPWNWSSGNGSRSVVHRNMASENSPGLLSRWLSSHYHGGVHDEKPVARHTVNLLTSTIKVDADQTDLRFCFRIISPTKVYTLQAENAQDQMDWIEKITGVIASLLSFQTPERAIMRLSTVDGGDTFSASDSGSLADPYDIEQAESGESTVEHPMTGGNRSRFSGCLQQHDMVKTEKPIDVLTRVLGNERCADCGAPEPDWASLNLGVLICIECSGIHRNLGVHISKVRSLTLDVKVWEPSVLTLFQSLGNVYVNSVWEELLNSESRTSSASRSSGTPKSDRPRKLLVRKPGFNDPISVKELFIHAKYSERIFVRKAIDSQHFQAVFQEIWENVRANDKKSVYRHIVCSEADVNALRGQASYTVSLPLSKMMQMEETLEAKFKSIEEEFQENPAGYSNSRGDGESMVREETSNDCSLLHLACLSADIGMVELLLQYGAKINATDSKGRTPLHHCIISRRYAIARLLLMRGGDPNAVDKDSNIPVKYASQTDLNDSELIALLTDSKR
The following text describes a protein:
Function:
Testis-specific protein that controls sperm transport and the timing of zona pellucida-evoked exocytosis of the sperm acrosome.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Multi-pass membrane protein. Nucleus.
Sequence:
MLRGGALLCFLLLLPPRLLPLHRSSPSIAPVASAPARRASRQSLQRRLQVLLLPSRGSHRGPDFPPNPRPGPNLGFPLGQDPEPDPVAASDCGSKWDLALGSKPAPGPGCQGALCPPLPPQFKPRSGPSSVPGRPAEAALLHILSASSLPLSQRSSGALHLSWGLQPSGSKLTFRLYQPQGQDHHQVWKVTCNPYLGAGGGLFCSPGPSPDLGAPKWTLAHLLLPGRGWAWGSRQVIGPALEGDLHLVNSTLGIRARGSTLSLNLRQAQTGSHGHGIYYSRAAPGHGRAWQAQTHLLFYQQQGLSWLFALDRWDRLSVHLSLSPKGVAFFGCRPPRDLEVHFFSSSPLKANGLFYLLWFIPLQHPLLRPQWTFHLQLPGTSLGLNRTYTYQDRIPRASRFIQRSVLPFRPDGYAGFVEKANCATSSLEPVILEASLDKYGSKVLRTPVACVQNPCYIKRMKILLNAPIERGLIAPHYDNSVLVEVICSVPYNSSHHWSVFKLPSDTDPKPSKENIVTGQKSTFSVPSTILKPGTYRLNYTLTITTSEQVATSSTFRDFTVSPPILYAYIEGGPARSVPFNKRWTLDGSRSRNVWYYTDPKIMKYRWYCTTNYTYFIIGNLPASSRDSCLPKLPDVRWFKATSPVVTVSPGTLRGNRTYYFILVVSLFSNRAYAYQNVTVEPGPPPKMKFSCIENCGKLLVVPDRLSLSSKCLDCGARPMKYLWSLMDSTKTEIPFNWTHWSTTGRTSTYLTIKAFAFKDFQDKMCSAILHASGWGGNFLVANHSFYVNSPPRNGYCDIHPNKGVALFTKFVVRCSGFIDENLPLHFKVIASNFWGVDNSSTVADNTLGTVMYFGLESVTPPSFLPIGMPVNHYMVRVYAQVYDFLGAFSQVTLHATVTSPQDRASPNTVLNYLLSLTQNTTGTMMTTLFQKGDFVQAGYLAYLAVSLLNDVTPPPNLQAQYSEIQHHLLNVCRHLPTTTLEEINQVTVMIMGLTKKGSGLTAEGQKAATSRLIEINLALQRLKEKEKEFLSEQIQIVSTSILSCLSNILKSEINEDMINETLHVIELLASTVLAVKSPGEMETVVTSPHLRISVWKDEKRNVNDAFLAQKDCQNCFYPTLRKNDSEYLARGGPISTAFYEFKQELSTSEDTGLSTDVVGFQMSEIKENGNIQEVIPDLVEVFLLRKNLSGAAFNITMGPDKDLPETTSGVFTFLVFGTDEEVLIQIITEVKVMFKAFIYEGSNVTHSLPIASFLVPPDMPTVANESKLFDPTCKVKFKVPRLICLSQSLLEATVQDYFASNWSISVVLQTPPIVMVPSDQLVNISIFLAECLKMEGNEKEWDKEDCKVGDKSSWWRIHCICEIKSKPMNESKPGESWKRLSRIKYLSARMIVIPNSIDLRMEILKTIPQNPVAVFTVVLIIFTYLVLAFWAMHKDETDRIRREHVILLPDNDPYDHICYLVTFYTGSRLGAGTKADVFVQLLGTDASSDVHCLSHPNFTTFYRGSTDSFLLTTRSDLGNLRAIRVWHNNEGSDPSWYLSRVKIENIFNRNIWLFLCRSWLSINKSLEQTFPVADKGQPMNKKDYFQIFASDNLGTRHLWLSVFSSVVTGPFNRLQRLSCCLTLLMNTLLCNIMFFNVEKEVEVSPMELKFLRTIMRGIESALICEPMQILLVSLFTYSHRKVKPVAITQVAPHVHPFMKSPFQNWKERLEMWYSLETAHKQAPGRSFLRKMQAQGSNVTIPEAVANAITETEEKPPNSEAFLEKNMTNTKPVDVAISREEQTSEESLSSSASLVRRSDAAKEDQGAEPASEESPQKSPKKVLLFEAKPRFFFHWWCIYVAWLLVIGSSGVSSFFIIMYGLTYGYEKSMDWLISSMTSLTESIFIIQVAKILLVSGIRSGRATYCKNIPWASRYNYLEIRLQELELNADDSRELHYEIIRIRGTRMYQPLVQDEIRIFRRRKKIRDRALIFLKNIISHLIFLTLLFCIISLARPSHSFHHNQAMQNQFSLKLTTITKLDDIYRWLTGVWLPLIHNDENPTFISNSWSKILGSPKMRQVRAKSIKRECFLSGTMVDKLMKKGIHCHSQYSQVMEDQKNYGRLWSTRSKFSVDPRPVSFTYEPNLRKWSYYSYGLSHAYGSGGYPFYFFPTQKQYNSTVRLQELQESRWLDEKTWAVILELTTFNSDTSLFCTISIVFEASPFGVINPSLAIHSFSLPLIYRESYFELYLYGGALMFIVLLLIDEATIIYWEKENYVKNVFNFLSLGLKLMFLMLILLFFVKFRLTKDILGFYLQNPDGFTPFHVISLVDQGLGIILGFLGFLTILKTLTYSRFFYDIRLAQTTILAALPGIFHMALLVGVYIFMYVTFGRLVFGQHEWHYSNLIHSTQTIFSYCVSAFRDTAFLNKEVLGGLFLASFMLVMICILINLFQAVFLSTYEEMKQLVYEEPAAEGEAITFLFHKVRNLWRTLTCRKPFREQPTYFSDILYGHPGNQSHQRLGLKSRNINGKRVTYVAV
The following text describes a protein:
Function:
Stimulates specifically the GTPase activity of SEC4, YPT6 and YPT36. Inactivates YPT6 during recycling between the endosome and the Golgi compartments.
Miscellaneous:
MISCELLANEOUS: Present with 768 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Note=Distributed throughout the cytoplasm and accumulates in punctate structures, which concentrate in an actin-dependent manner at sites of polarized growth.
Sequence:
MSFFDSLRQKAPFLDKLADSFTPTLTRDEKFRLKYKLPANENILEDTNAEVSFATSIKDGKGHSDRVNNKGRKTAYVYSGRLFLTPHFLVFRDAFDHSSCVLILNISTIKRVERSPSESYEFALLVTLYTGAKVLIQFIGIRYRSEQFCDKLKLNLKENIPNAKTLPAFLETSYSEFLIAKNILGKKDITVPRAGLGQHFKYPGNPTMVKEKAKLRLWFDYFRENGRNLAVVQTPMFRKLIRIGVPNRMRGEIWELCSGAMYMRYANSGEYERILNENAGKTSQAIDEIEKDLKRSLPEYSAYQTEEGIQRLRNVLTAYSWKNPDVGYCQAMNIVVAGFLIFMSEEQAFWCLCNLCDIYVPGYYSKTMYGTLLDQRVFESFVEDRMPVLWEYILQHDIQLSVVSLPWFLSLFFTSMPLEYAVRIMDIFFMNGSITLFQVALAVLKINADDILQADDDGMFIAIIKHYFQTLGQSAHPDSSDIKYRQITKFQELLVTAFKEFSVISEEMAMHARHKYEKGIFQNIETFMKRTQLRHMPKTFNLSSDDLSNIYDMFYQSIETYKISMGTGSSNMGFEVFIQFLSKFCDSCRPCEKDKDPAFRKQKRNFLQRLFDNWDSAHIGELTLNDVVTGLDKLVTVDLLQAINYFFSLYDTDGDGELHREEVLQLSEGLLLLTEPWKSGRYVDLLTKKRIEDDIAENIIKESGGEIATMNQIELPTGVTIDEEKYKVEQAERYLKAASNFLQRSFEYAKAVDLAEEVNLIDLSDDEGEEKRTVKQKQLESIKANAALDPTHPKVIDLPTFRMIILADETYELFFSNTLRSSVHVDEHVNIDNKNKVLRSMFDGILADGKRVAEQVRRRVDSVATRSSIASVESTPTAAASSITTKEEKYDDLDDFTSEHQPENEELLQSSWFEIDDANETSTKAIQERSFEPLSANSSEEKSNLIEFEA