lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria. Also acts as a mitochondrial small ribosomal subunit (mt-SSU) assembly factor.
Subcellular Localization:
Mitochondrion.
Sequence:
MSVRVARVAWVRGLGASYRRGASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVRELYAAARRVLGYDLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGLYAVKIRAEAMQEASEAVPSGMLSVLGQPQSKFNFACLEAREHCKSLGIENPVCEVSNYLFPDCRVISGHQEALRFLQKNSSKFHFRRTRMLPVSGAFHTRLMEPAVEPLTQALKAVDIKKPLVSVYSNVHAHRYRHPGHIHKLLAQQLVSPVKWEQTMHAIYERKKGRGFPQTFEVGPGRQLGAILKSCNMQAWKSYSAVDVLQTLEHVDLDPQEPPR
The following text describes a protein:
Function:
Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MQPKINWIDNLRGIACLMVVMIHTTTWYITNAHSVSPLNWDIANVLNSASRVSVPLFFMISGYLFFGERCAQPRHFLRIALCLIFYSVVALAYISLFTSINVELSLKNVLQKPVFYHLWFFFAITVIYLVSPLIQVKNVSGKMLLMLMVIIGIIANPNTVPQKIGGVEWLPINLYISGDTFYYILYGILGRAIGMMETQKSSLTLICTALFIIAVFVISRGTLHELRWRGNFADTWYLYCGPMVFICAVSLFTVVKNKLNARTLPGLGLISRHSLGIYGFHALIIHALRTNGLELKRWPPLDIVWVFAATVTGSLLLSMLLQRIDKRKWVS
The following text describes a protein:
Function:
May promote the activation of caspase-3 and apoptosis.
Subcellular Localization:
[Isoform 2]: Mitochondrion membrane; Single-pass membrane protein. Nucleus; [Isoform 1]: Nucleus.
Sequence:
MASSSTVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQGVQLDIASQSLDQEILLKVKTEIEEELKSLDKEISEAFTSTGFDRHTSPVFSPANPESSMEDCLAHLGEKVSQELKEPLHKALQMLLSQPVTYQAFRECTLETTVHASGWNKILVPLVLLRQMLLELTRRGQEPLSALLQFGVTYLEDYSAEYIIQQGGWGTVFSLESEEEEYPGITAEDSNDIYILPSDNSGQVSPPESPTVTTSWQSESLPVSLSASQSWHTESLPVSLGPESWQQIAMDPEEVKSLDSNGAGEKSENNSSNSDIVHVEKEEVPEGMEEAAVASVVLPARELQEALPEAPAPLLPHITATSLLGTREPDTEVITVEKSSPATSLFVELDEEEVKAATTEPTEVEEVVPALEPTETLLSEKEINAREESLVEELSPASEKKPVPPSEGKSRLSPAGEMKPMPLSEGKSILLFGGAAAVAILAVAIGVALALRKK
The following text describes a protein:
Function:
Plays a role in the establishment of normal sperm morphology during spermatogenesis and is required for acrosome attachment to the nuclear envelope.
Subcellular Localization:
Cytoplasm, cytoskeleton, perinuclear theca, calyx. Cytoplasm, cytoskeleton, perinuclear theca. Note=Localizes to the subacrosomal layer of the perinuclear theca in round and elongating spermatids. Localizes to the calyx, also known as post-acrosomal region, in spermatozoa.
Sequence:
MSLSKLDSEKLTIEDVQTSSSSCRREINTTTYDDYILSIQTSEKQNQEHFVLTFPKTPMPDKKKRSGPSELEVAVPIQVKRKIEKDQKPTHVWINQFLRDIFLKSSFSRPFITQAPFKYLYNPQNHYTMAESRKSKNDERRKTLKIKFRGKISSCVVNLEPMRTITNGEPEILGNTEKNPSKSSHKIKLPKTSNSTSETNLEYNNSKKTLEMSLRNGNKNSMNFVLKGNAATCCKDNPNTDSKKSVEEFSDDISECINSSNMDLMLRLNEFRAEFTDLDVWSTNCSQNNAKKPLKTGGKKERDSDIDSGGSKDAKKEGKKKGKRESRKKRNTESSDAESGDSKDGKKKSKHDKKNEIKKKKDTDSTGSGSGASMVSKKGKTEKKSTGKKSTGSTGSESVDSKSTNKVKKQVKKGVMKKAVSTDSESDASSKKSKKDEKKENKGRKKKPIKDTESTDADSESEGDSTGKKNEKKDKKITKKGEKKDAKKNTASSESESDLGVNKKKTKIKEIVSFSDSTSDSYSKAGRRKNVRRSDSESEDSSGFRVLKSTDDSEASSTDSKTGMPGMRRGFRSLSKKTTFNERGKRSVTGRIPSSRERLPFPPCEPFRASPKPVHVCKCKESPSPKARYAPLPGVEWIHKLL
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MIGSKVQSYNTNVTSNKPNSIGLAGGNIPNSNNSIPLNSNSYNLSRFSNPTLNTENILTNIISMGINKVEWSVYRSINSTNNYNNNTNSCNNINSKNLINDPILLLYLKTIEKGIPCLWRKCKVSKKSNFDKFGNDSNLSSSKNSPLNNNNNNNNNNNNNNNNNNINNNNDNTVSPRDNQNKTSPSSSSSSSSSTIVTNTNSTTTNIGSSKNSPKTPSLSAPSPISPSNITKQQELQSPSTNSKSPPPTPPISLQLNKNQILASANTENEQSIYELWVFNIDGSQLDFLDLQSIDSGILCIDSIDKNCYNSFIYQFLFKSLYNLIEYNMVSNDFIKIGSSFIKSSHILQHQKVTNTSNNSKSATSLASSNNIEGLISNISNKKRLFDGFSNLFIDEDSLLSCSFSFFINNKSVYLHFIVDRKRLKPIQDLLKSEYINSPLFTSPNSFIAFYNNGNFKDIKNNETLSSNSTPIQSQNNININNNNLENLTIPIKPNPIVEQKRKFQDEEELNFILSSQQWKQLFNIGLTNKSLYPKFIDNKSTQITKSYNHLQIPKSIKTIITRGNSSPLINTFFPIELLFKFIPQVSDISQFIFHEKQKEMGFEIIERSPYSILEKGLNLNLKQHQHQHQHQQQQQQPQQQVKSKYVDFWSLPLFHSRESLSQQVNVDFNSTFSKPLPSPSSNSPIPPSSPGNSIAHSPFNVNSPSANIPQSPKTPITSPEDHLQDGDIHITTGDKKRQSKQQKKGRSSKRKKEDVQQPANDTFLVPLTKPTNSTITQEPIQQNLPSQTVQHEQQQPIQQQPQVQQSQPQQLQLQQHEQQINNPFNSSMDIFGADFDEIKSKDDDLMHLSVSDMDLDLWTSHYYVAPPPNSIKPNQNQRQVPNNIDDPFQSFNIKPQTTNETNLNLPPPQLQQQLQQPPQLQQQLQQPPQQQEQLQQEILQPIQQPPQQVIPPQQSQPQQQNINKSSKEGINISDNEKPFLDAQFLCPVPYKAPSLSQNHLPIPHHDSPLIDSIMSEHTRQNSGSIGSNSSTGGVSGNQNEIGLSFSSENHLSQSPHENLILRNSLGGGDESIDGLTTFYGNLTLSRANLDQSSKNKSNAPYYCAPSYKPLDEHTLPIQPKFEYTYTPTQKPSNQMNQTKYSPFTAHSNLHNYPHQPTSQQTQQPSLSLSNQKINYSSPPISPKMNGRSSQSINIKPTNESLGDEKIDQQQQDQHNFATQEQDDKNVFFKTTKQKQEEDQPKPSSSALLSFFDQSLSFSPTSPLVNYPTPSLTTPINPSSLVNQANKSPLLQSIQPHHITNDECFDLAYVIQQLSITNYDSTFGFSIDNSPLIRQSVDYYIENWLKVYSETGKLFNHHNLQFLTEEYISDALETVIDPITTNAILETSVKNLYSVSNEIIKKIFPLSTNPLSIKEFCNNINNNINNNDILNNDDDTILTQQNNLNSSIDKGMMSMDTDEFSISSNLTNNNINNNNINNNNNNNNNQIEKQLQQHQDYSFEWLPIPKIIVGHKEDWLEVPITTLRFWDKAQLEPYSPKKNITYFVLCPDTPAMRVHAPAFFSDLSCIYETNHLGNHVTQQQSFQQQQQAQQEALQKQQQQQQKSPFHNNPYHHQQVQQQQQQAQLQQQQKSPFYSGICYISSPFSTSTTTSASNTSNNNNNNSETNLNSYIDTYYLNCIQFGNYLKDLSTKYTENNCIVLYIVNPFSDLSSQNNNNSNTNDNDNNNSSTINNNVNNNNMKSSTSEDINHLRNSYLFTSSCFQTILRDTSIQQFLNVTIQTIPIEQVLLDDPSSSSVTKELAFSVFNKCRRISTLSSTQTIHFTSQINQLNNNNGGNNTTNNSNNNWYHKLFSKIYEPLFILSQAEQPQQQITTIHFCYTLSDDNKWLSCSLVDDYGEMLENKLIPLAVSETTGDYLWKDSFQNAWFFISEIIGLSLSGSLCSVVIGKFGIISKQEYNDWQTTIEHFEKNLESQRTQVPLVDKIYNIESVIFLNLTFNTSFKSFLTEFINDPKLENNSIKSVSPLSNQTFAIYPNNPIYYSYNFPSIFDNEEDFTLLNNNNNNNNNNNNDNLLPLSTSFVITSPGITSNNITKKELPFTYMISIVGIQNVNKQQNQNYQETIKFITKSYHKLSYLNISPKFPDRLSVLPIHFSISKRMSRTVCLISPNTQLSAPILYHRSPKITNLKQ
The following text describes a protein:
Function:
Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MDAAGAGSSSKPTPTRPRLAVRIRGRPSSILSRADPAEWRSRPAVSWTVENIYEDFSGRRRALVGALTQDQEKLYDLLCEEGKERMCLYGYPDGKWSLTLPEKMLPPGLPEPKLGINPRPEYMNRYDYLSYVVRHSDSWLMGVALFLTTLLDAKQKMRLFDMVNKISTVHDEFYLSYGTSWILTFAPPSRDIAPNVYNPNRDSSAPAQENMYNPDVDSITPAEVNMLPYQDSMQGLSAPNKGSRKPAEEKGKDHEATDFCGVCSAAYHANAFWICCDICDQWFHGKCVNITASESKHLKVFKCRDCILDEIGE
The following text describes a protein:
Function:
Involved in trafficking and recycling of synaptic vesicles.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Early endosome. Golgi apparatus, trans-Golgi network. Late endosome. Membrane; Multi-pass membrane protein. Recycling endosome.
Sequence:
MPARNILSDDFPGSRVKYSRLASDDDGYIDLQFKRSPPKVPYKAIALATVLFLIGSLLIVIGSLLLAGYFGVTHSDRTVPVLIIGILVFLPGIYHLRIAYYASKGYPGYSYEDIPDFDD
The following text describes a protein:
Function:
Promotes cell proliferation-dependent organ growth.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum.
Domain:
The OSR domain is sufficient to promote organ growth.
Sequence:
MIRKTPNLQNDIINIQERYSNNLVMDVGGGRNSRKNVNFRRPPPAMTSENSKHELRRTFSSQKRLMIPANYFSLESLVILVGLTASLLILPLVLPPLPPPPFMLLLVPIGIMVLLIILAFMPSSSSRAKDVTRTFM
The following text describes a protein:
Function:
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSEDNCLQPQLSPLFLSCSTKKAMESIAPILEGFTPKTSSSENTSLKLPPASLTTDEEEDADENLDPNALARTVSVQSQQSAVGGTGAVTYNSLAAPDENAETFAKHGAAHGLEQITSSQALEECACEEGNCTDACQAVSPGAYKGQSPRKPADDATEKNEGWQHSVHPPVQQTGHEGANSDSATPAPSSSSSSRKSSTSITKPQLPRVGKIGVCAMDAKVLSKPCRHILNRLIENGEFETIIFGDKVILDENIENWPTCDFLISFFSSGFPLNKAIDYVMLRKPFMINDLIMQKVLWDRRLCLRLLEAAQVPTPPRLEITRDGGPRVDDALRSKLLERGVHVKPIREPIWRMLDNDTLEVNGEIMTKPFVEKPVDGEDHNIYIYYHSKNGGGGRRLFRKVGNKSSEFDPALVAPRSEGSYIYEKFMDTDNFEDVKAYTVGESFCHAETRKSPVVDGIVRRNTHGKEIRYVTELTEEEKQMAARVSKTFSQMICGFDLLRVNGKSFVIDVNGFSFVKDNSMYYDSCAKILRDTFVNAKKQIDLEKRNLPVIQEEKRQKWFFKGLVTVIRHADRTPKQKFKHSFRSQIFISLLKGHKEEVVIRNVSDLQIVLQALRIAMEEGVEDPNKLEVLANALEKKLNFPGTKIQLKPVLNDDNEVEKVQFILKWGGEPTHSARYQAQELGEQMRQDFDLLNKNILRNIKIFSSSERRVLASAQLWAMALFGADELGSDEISIRKDLLDDSNAAKDLMDKVKKQLKALLREGKEAPPQFAWPLKMPQPYLVIKRVVELMNYHKKIMDHNFSHKSLEEMQRRWCCGEDPTLFKERWDKLFKEFVSVDKVDPAKISELYDTMKYDALHNRSFLERIFSPDEADELNEDAACQHSLVDRYPINILAKNNFKIPETTLGKTTSNSVGSLGWVLEKESGMKAHCSNPNSIFDHPRYMQLRELYRLSKVLFDFICPQEYGIEDNEKLDIGLLTSLPLSKQILNDIDDMKSKDTPACIAYFTKESHIYTLLNIIYEAGLPMRIARNALPELDYLSQINFELYESADSGGQKSHAIRLKMSPGCHTQDPLDVQLDEKHYISCIPRISLTKHLDMDYVSQKLRNKFSRVNMPQKFTPVHITQPDLSYKRPAMKDSSTES
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MERDFLGAIDRAWKCGEAAKEESRSEPDSPAATRWQFAARSGVAPAFMSFRTEATGEGSEAFSVSELRPAGDAFDGIKKQSSMLSIYQQQRQFGHNSSQATAQQQYPAAAHRQRSQVADYGAAAPHRLPGGGGGGCRLVQPVSVRHPVPFHQANLMVRSSVSQSFHNQQQPFTMSNNGFGGSTAGVYGARNPRNQASTQLTIFYNGSVNVFDNVPVDKAKELMMLASRASVPGATPSSEPDSPPVPAPAPAKVNVAEVFPGARQIAVQKPEPCVPHLSSAATASPVRIVVPQAVAPSRSTSHCATEACGSKPAAAPTSQTVSSSRQLAAASAAAAVTPRAVPQARKASLARFLEKRKERVASVEPYLTSNSKSPLESSDAVGSASAPTKSSSTDVAPASSHNGGGAELVRHGGYPRSISFSTNLQI
The following text describes a protein:
Function:
Aminopeptidase which preferentially cleaves leucine residues from the N-terminus of peptides. Also, has some activity towards tryptophan and methionine and has very low activity towards alanine, arginine, asparagine, phenylalanine and tyrosine. No activity towards histidine, serine, valine, isoleucine, glycine, aspartic acid and glutamic acid. In addition, cleaves the Cys-Gly dipeptide, probably as part of the glutathione regulation pathway; cleavage only occurs in the presence of Mn(2+). Plays a role in the final step of host hemoglobin catabolism, by cleaving hemoglobin-derived oligopeptides providing a source of amino acids for the parasite protein synthesis and for the maintenance of osmotic homeostasis.
Subcellular Localization:
Cytoplasm.
Domain:
The L13 loop movement regulates the transition between active and inactive conformations by repositioning Lys-402, which, in turn, mediates the rearrangement of the binuclear metal center.
Sequence:
MPLLRSSQHIKNTYWNIPKKSFRTGVPQFAESKKTRILHLHPLCKSASGVESPPFFDSQTFSSISNRKEFRKMATTVPQVVSLDPTTIPIDYHTPIDDLSIEVKDISAEACPADEGLIVFLLNSAPKHSSSGGSGGNGGSAGSSGNGEGGAQIKINSSVKDNTINEFLKEGNMENFTGKLGTSKSFYIANDQKKYVSLAYVGCGPANEETELEIRKVAYALVTLLHDSKHKKVSIIFEIKIEEALFRFFLEHLFYEYVTDERFKSADKSTETDFIKNLSLHIANADAYKGQIDKARVYFYGTYYAAQLIAAPSNYCNPVSLSNAAVELAQKVNLECKILDVKELEELKMGAYLSVGKGSMYPNKFIHLTYKGAQTGASQNEKKKIALIGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCIGTIKPDNVEVHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNDQLINKILSSSKTSNEPVWWLPIINEYRSSLNSKYADLNNISSSVKASSVVASLFLKEFIENTPWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLNDAV
The following text describes a protein:
Function:
Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway. As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Sequence:
MYNRATGTSSGSQGTVSVNIPAENVDKTLPDVVPDKGSALWNRVHLGTESLSMENFHPFKSQAGLLTRAAREVGRVLAERRARRVMFIAVLNVLCTLVLFVWCRTTGSMALLAYTYLTVFDILCLVTCLISIWVSIQKPTPAFSFGYERFEVLAVFTSTTLAQLGQLFVVKESIERLLHHHDVHTGRLLVGTAFGFAVHFVSTYFVTNKAFQHVSEASSSSWLQEHVADISRSLCSVIPGLSTLLLPRINPLPLIAVAGALALFITDMLIEINNYFRADTFAAISIAIMTVGTMFPMSVYSGRILLQTTPSHIIGQLDKCLREASTLDGVLEFRNEHFWTVSFGTLAGSLHVRIRRDANEQMVLAHVTNRLSNLVTVLTIHIFKDDWTRASLSSSSYAPRQPYTSTPAKPGLDSSVPAINPFQSLPPLAPNLSTITPIGSPAGPSLHQPGTRLYGTGTTAPSHMTLGPAANTGGRIPLRTYQPTDLFGASGGAGQKSTTEHGHSHSHR
The following text describes a protein:
Function:
Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. Causes reduced proliferation of B lymphocytes.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MGTRWATPGRATGLLVLLLRCFELVEPSGNNPFTIVNENTGKCLQPLSDWIVAQDCSETKNMLWKWVSQHRLFHLESQKCLGLDITKATDNLRMFNCDSKAMLWWKCEHHSLYTAAQYSLALKDGYATASTNSTDVWKKGGSKENLCDQPYHEIYTRDGNSYGRPCEFPFLIGKTWHHDCIRDEDHKGPWCATTLNYEYDQKWGICLQPENGCEGNWEKNGQIGSCYQFNNQEVLTWKEAYVSCQNQGADLLSIHSTAELAYITGKEDIARIVWIGLNQLYSARGWEWSDFKPLKFLNWDPGMPIAPVIGGSSCARMDTESGLWQSVSCESQQPYICKKPLNSTAERPDDWTDSDTLCDGGWLPNKGFCYLLANESGSWDAARMKCKALGADLTSIHSLADVELVVTKLHSGDVKEEIWTGLKNTNSPTLFQWSDGTEVTVTHWNENEPNVPYNKTPNCVSYLGKLGQWKVQSCEKELRYVCKKKGEITKDARSDELCPPNEGWKRHGETCYKIYEKEVPFGTNCNLTITSRFEQEYLNDMMKNYDKSLQKYFWTGLRDADSRGEYSWAVAGGAKQAVTFSNWNFLEPASPGGCVAMSTGKTLGKWEVKNCRSFRALSICKKMRGPQASEEAAPKPDDPCPEGWHTFPSSLSCYKVFHIERIVRKRNWEEAERFCRALGAHLPSFSHRSEIKDLVHLLKDQFSGQRWLWIGLNKRSPDLQGSWQWSDRTPVSAVIMDWEFQQDYDIRDCAAVKVLDTPWHRAWHFYDEREYAYLKPFACDAKLEWVCQIPKGSTPQMPDWYNPERTGIHGPPVIIEGSEYWFVADPHLNYEEAVLYCASNQSFLATITSFTGLKAIKNKIANISGDDQKWWVKTSENPIDRYFLGSRRMWHRFPMTFGDECLHMSAKTWILDLSKRANCNAKLPFICEKYNVSSLEKYSPDPSAKVRCTGKWIPFQNKCFLKVNSEPVTFSQASSICHSYGGTLPSVLNRNEQDFIISLLPEMEASLWLGLRWSAYERINKWTDGQELTYSNFHPLLVGRRLSIPTNFFDDESHFHCALILNLKKSPLTGTWNFTSCSERHSLSLCQKYSETEDRQPWENTSETVRYLNNLYKIVSKPLTWHAALKECLTEGMRLVSITDPYQQAFLAVQAALRNTSFWIGLSSQDDELNFGWSDGKRLHFSNWAGSNEQLDDCVILDTDGFWKTADCDDSQPAAICYYPGNETEEEVRPLDSAKCPSPVQSTPWIPFQNACYNFMITKNRHKTVTPEEVQSMCKQLHSKAHSLSVRTEEENTFVVEQLLYYNYIASWVMLGITYENNSLMWFDKTALSYTHWRKGRPTVKNGKFLAGLSTDGFWDIQSFNIIEETLHFYQHSIFACKIEMVDYEDKHNSTLPQVIPYEDGVYNVIQKKVTWYEALKECSQSGGELASVHNPNGKLFLEDVVNRDGFPLWVGLSSHDGSESSFEWSDGSAFDYVPWNSPQSPGDCVVLYPKGIWRHERCPSVKDGAVCYKPTKPKELSSHTQSSKCPVAKREDVQWIQYGGHCYSSDQALHSFSEAKQLCQELDHSATVVTIADENENKFVSRLMRENFNITMRVWLGLSQHSLDQSWSWLDGLDVTFVKWENKSKDGDGKCSVLIASNETWRKVECSRGYARAVCKIPLSPDYRGIAILFAVLSVLALISGLIWFLLQRTHFHWTGFSPVRYEHGANEDEVMLPSFHD
The following text describes a protein:
Function:
Plays an important role in the degradation of dermatan and keratan sulfates.
Subcellular Localization:
Lysosome.
Sequence:
MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKKLDGLWSFRADFSDNRRRGFEEQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTTLPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQDSGLVNYQISVKGSNLFELEVRLLDAENKVVANGTGTQGQLKVPGASLWWPYLMHERPAYLYSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVLQMCDRYGIVVIDECPGVGLALPQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAVLPACPWLDWEGDPGRWLASVGVSASRPAQWEGCPYPDSSGDQISTHPNCGFLFCSFFFFLRWSLTVCYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSPFT
The following text describes a protein:
Function:
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
Subcellular Localization:
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Sequence:
MHSSSSASTTSSGSTIHEEFDEKPTFNFSWPPGQAFPFEPLPPYPAGPNLSKIRYPREVTCPRYICPHCEEQFLFHSTNGLLTCPFCYTSIAIGTYNRKQMYLNFVVGTIVLIISMVMTVLVFTIAKDQVYLSIPAIMLFFGAIIFFTKALQSKDSYEEAKILIEDMDV
The following text describes a protein:
Function:
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVYQVSSPTYDIDYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTIPFWAHYAAAQWDFGNTMCQLLTGLYLIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGLVTSVITWVVAVFASLPGIIFTRSQREGLHYTCSSHFPSSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHLAKRFCKCCSISQQEAPERASSVYTRSTGEQETTVGL
The following text describes a protein:
Function:
Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).
Sequence:
MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA
The following text describes a protein:
Function:
Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
Miscellaneous:
MISCELLANEOUS: Each Drosophila eye is composed of 800 facets or ommatidia. Each ommatidium contains 8 photoreceptor cells (R1-R8), the R1 to R6 cells are outer cells, while R7 and R8 are inner cells; MISCELLANEOUS: Opsin Rh3 is sensitive to UV light.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MESGNVSSSLFGNVSTALRPEARLSAETRLLGWNVPPEELRHIPEHWLTYPEPPESMNYLLGTLYIFFTLMSMLGNGLVIWVFSAAKSLRTPSNILVINLAFCDFMMMVKTPIFIYNSFHQGYALGHLGCQIFGIIGSYTGIAAGATNAFIAYDRFNVITRPMEGKMTHGKAIAMIIFIYMYATPWVVACYTETWGRFVPEGYLTSCTFDYLTDNFDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKALRDQAKKMNVESLRSNVDKNKETAEIRIAKAAITICFLFFCSWTPYGVMSLIGAFGDKTLLTPGATMIPACACKMVACIDPFVYAISHPRYRMELQKRCPWLALNEKAPESSAVASTSTTQEPQQTTAA
The following text describes a protein:
Function:
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Sequence:
MPSETSKKRTIFVSSRKSQLAMAQTTTVIGMLEERFPELQFVVGQEDTVGDQVLDRHLSDLGTTTASGLFTKSLEDALLAKTASFAVHSLKDMPTTLPDGLVLAAITKRESPEDAAVIHPKHKEKGITTLQQLPEGSIIGTSSLRREALLRSQFPTFEIKVLRGNIQTRLAKLDEHDDYDAIIVAACGFRRGDLGDRIDEILPMDTFGYGVGQGSIGVECRADDEETIKMLETITDEKSAQLCKAERSLLYHLEGGCQIAMGVSATLDEDTLTLNSTVLSRDGKESVHETISGPRTEAEELGKTLAERFWDNELARKVLGKTREKRALTYGDAEAPGDAAAAAKKAKTSE
The following text describes a protein:
Function:
Deubiquitinase that mediates 'Lys-63'-linked deubiquitination of tight junction proteins, such as MARVELD2 and LSR, and which is involved in the survival of auditory hair cells and hearing (By similarity). Specifically cleaves 'Lys-63'-linked polyubiquitin chains composed of at least 3 ubiquitin molecules, while it is not able to deubiquitinate substrates with shorter ubiquitin chains: recognizes ubiquitin chain in position S2 and catalyzes en bloc cleavage of polyubiquitin chains from substrate proteins (By similarity). Probably acts by modulating the barrier properties and mechanical stability of tight junctions via deubiquitination of MARVELD2 and LSR.
Subcellular Localization:
Cell junction, tight junction.
Sequence:
MAWVKFLRKPSGNLGKAYQAGSLLSLAPTVGLLNEPGQNSCFLNSAVQVLWQLDIFRRSLRALTGHICQGDACIFCALKTIFAQFQHSREKALPSDNIRHALAESFKDEQRFQLGLMDDAAECFENILARIHFHLVPNRDADMCTSKSCVTHQKFAMTLYEQCVCRSCGASSDPLPFTELVRYISTTALCNEVERMMERHERVKPEMFAELLQAANTADDYRKCPSNCGQKIKIRRVLMNCPEIVTIGLVWDSEHSDLTEDVVRSLATHLYLPGLFYRVTDENATDSELHLVGMICYTSRHYCAFAFHTKSSKWVFFDDAHVKEMGTRWKDVVSKCIRCHLQPLLLFYANPDGTAVSTEDALRQVVHWSHYRSGEENMGCGKPIIYKPDNSKENGFGGQTKQKENHKFQTDISSLNRSQMQTSGRRAPVKLSHDQREKIKDISRECALKAIEQKNALSSQRKDLEKGQRKDTGRHRDLVDEVLASFKSGSPPASDGFRQQGNPHLYHSQGKGPCKHDRATHESYTSGKVISSSKSQNLLVPGEKTTGKAKSDSGTGYETDSSQDSRDKGGSYSSKTKSRHRGWKPMRETLNVDSVFSESEKRQHSPRRKSDIGSRPRCSKDQSFNNWPKANPKQKGLMTIYEDEMKQEAGSRSSLETNGKGAEKNLSAAESRGPGTSWQMQRTESGYESSDHVSNGSASLDSPGVEGSGAVMDVGGGKAFSEHIKMNSHNMDSMEYISHHCKDHPEGFRKELQDLEADDKIHELHPESHVQIKSHLIKRSQIGETNDKLFPSASPQTLAREHVYQTNEHKVERPDRSKCSERHNTENSEGTGLPFHVDESSVAGKRVDSNETVSPSSLPSSVRTAGLKPETGPLMFWSQQNITEQGYSDNSLSRELTLLSACNADSCQMPKLHCHRSPPPLPPKKYSTASAPRLERVGLSPDVGVTEAFNTNPSSLPKHSLSPASGPSLEGSPCMTQERDKETIQVKQLAANSYPSSCSTNSFQPDQDSTSVCPNETISLTTYFSVDSCMTDTYRLKYHQRPKLYFPESSGHHSNNSLSQTEQVEGSIT
The following text describes a protein:
Function:
Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.
Subcellular Localization:
Nucleus.
Sequence:
MGAQRSEGGRDWQEQEEAENPEKITRPWNLMIKHRHIHKRGRRSLSAVSYTDPHVSMDLLRAVLQPSFNNDIMAVFMKYQKFYEKAAENVKENVGMEVQTDHLIREAYRNALEHAKQLFPENEVKTAGPGVSMKRLPKASDEEGSQRGSSFPRKVRWQHLLYVRCCIDPVINGSVSPQRKSRPTVAFSDRPTTYIPVKPKIEAIRREGPKWDPSRLSETTTFVLGSRANKALGMGGTRGRIYIKHADLFKYAADSKDKQWLAERHHMRATGGKMAYLLVEEDIQELSCSDEYRESPEVRMDELKPFTVPIWMVEKMQQAMEVQKNVDP
The following text describes a protein:
Function:
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
Sequence:
MAAGHRRRAASPEAQRLLPGIGTGEHARSRGPGCRPRLPPPTARAPVTTVLCGLCRASVLEPRRSWSTRLPVLPAPDRHVSWGRDGGRVQGGASALKGTGHGAREAAPFETARGAWCGAGLGSWTHQSRTPVSRLKEALSRQHRPLLSLSPEPGIMAEKVLVTGGAGYIGSHTVLELLEAGYSPMVIDNFHNAIRGGGSMPESLRRVQDLTGRSVEFEEMDILDQAALQRLFKKHSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMRAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKAWNAVLLRYFNPIGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREVLNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLALKELGWSAALGLDRMCEDLWRWQKQNPSGFGTQA
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrvAB PTS system is involved in fructose transport.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The PTS EIIB type-2 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain; The EIIC type-2 domain forms the PTS system translocation channel and contains the specific substrate-binding site.
Sequence:
MESSLRIVAITNCPAGIAHTYMVAEALEQKARSLGHTIKVETQGSSGVENRLSSEEIAAADYVILATGRGLSGDDRARFAGKKVYEIAISQALKNIDQIFSELPTNSQLFAADSGVKLGKQEVQSGSVMSHLMAGVSAALPFVIGGGILVALANMLVQFGLPYTDMSKGAPSFTWVVESIGYLGFTFMIPIMGAYIASSIADKPAFAPAFLVCYLANDKALLGTQSGAGFLGAVVLGLAIGYFVFWFRKVRLGKALQPLLGSMLIPFVTLLVFGVLTYYVIGPVMSDLMGGLLHFLNTIPPSMKFAAAFLVGAMLAFDMGGPINKTAWFFCFSLLEKHIYDWYAIVGVVALMPPVAAGLATFIAPKLFTRQEKEAASSAIVVGATVATEPAIPYALAAPLPMITANTLAGGITGVLVIAFGIKRLAPGLGIFDPLIGLMSPVGSFYLVLAIGLALNISFIIVLKGLWLRRKAKAAQQELVHEH