lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Subcellular Localization:
Cytoplasm.
Sequence:
MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPVIADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDAVGGVLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMEQDQGGANGELMGLRVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSRSEQLRITPE
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. Plays a crucial role in maintaining the genomic stability by controlling the degradation of multiple proteins involved in mitotic progression and DNA damage. Regulates epithelial homeostasis by mediating degradation of CDKN1A and isoform 2 of TP63. Plays a regulatory role in innate immunity by negatively regulating IRF3 activation and IFN-beta production. Mechanistically, inhibits TBK1 phosphorylation and 'Lys-63'-linked polyubiquitination independently of its E3 ligase activity. Alternatively, promotes 'Lys-27' and 'Lys-33'-linked ubiquitination of IFIH1/MDA5, promoting selective autophagic degradation of IFIH1/MDA5 to inhibit antiviral response.
Subcellular Localization:
Cytoplasm. Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MTSTTIAPVAPTAPTLVAPSTPAVLPSSCRSAVPVVTIRSAELPNTGDGTGGRLIRRKEFLGESNRTTSLKTLSCDLSEILVKNLSLRRSETSERRPHADTLEQLEPATSSGPVVQQHPQCIGTAGSGTIDGRVSSSGSGAASGDSRAQTTLCDTFTSVNKLIRLKRVSSDGNNLSRLSTVVTTTNASGGCGGGPGGGAGANYTKILEPDPGKPPPPSGSFKRVEISVCERTPSVTQCGDHGPDRQPPVSESESESGEECANNEYPKQRAAAPVHKSVIVNQLDQVDEHCPLLAVNEDGRAPTALALQKKKATLVFTRKKIPEAAATVRRSSERDLTSPGVGASSCSASKVLVRRRVRLSGDWLGRSVDNGEKVEFKRRSLQWPIGLTSGDSRTTTQLADLVEGNRRSGADTANKFRHSWNAPGYDILEEDSGVEQRGVDFGKDFASIIHNLAGLRNHHLANGTHESVSLLEQHSPQIVPTRAARPTSLGGSGQGLRRGPASWIQSSPMVPSSGVAGTGAGAGPGGGGVGGTGGNGEGSPHTGSLTGPVPRKRRFEAFLKNLVGRRPSKEPPPAAPPPPPPPLLSSPEIKISKSPSEHNLADIARSRLNISTTSLSSVHQRLWSVVPLLKRDVSCNSLASPKTTPLLLDSQMASSGEGGGGGPGLLTLGGLKAGAAGGPRGLRKCETVLALTNATSQTLEPIRPLNRLRNCASVATCSRCSSLLSLAAAGSRYSLNASNGAFVPVSATEAHEPTEVPKNPKKGSLDGGSKRKYVGNLLRLTTTSCSSSSSSSGASSPSSSSTPSSSSSGASSPSPNSATGSPAGASVSSKTVMFSPSPTQLLPVSPINSHSATTTTTTTKALTPTIKFTCKLCLGEFSAENLTRITQCACSFCTECMTAYIEFEISEGAYEVSCPDAMCPAQGIITIAEITALASSSLVEKHHRYRLNREVELDRFRTWCPKAGCETICLVGSREQQAGDQAGANQTGSSICSDRIVPLSPSSSSMPSPCAVHCPTCREDFCSGCKKAWHPTMSCEENSRRLAVDGQTDALGIPFDNDLIKCCPMCTVPIEKDEGCAQMMCKRCKHVFCWYCLASLDDDFLLRHYDKGPCKNKLGHSRASVVWHRAQVIGIFAGFGILLLVASPLLLLAAPCIVCCKCRICSGAAKLEETEVDYDDAAVALHSSTGPQR
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein. Nucleus.
Sequence:
MFAFRVLHTVPYSNEPAANDVIAKLHSFITANVLIGAALVISFRQFGGKPIDCMVPTDFTPSWTQYAETYCFSQETYWVPFTSVVSYYQWMPFFLLFEAACFKVPCLIWKYFASQSGMRIGEILRLSSSDTNGVPEVKKSNVEALGVHLNGALRFHKILNHRRLIPHKILRFLNVKYSTYYVTLIYFIAKIAFLLNIGVQIKMLEKYVLPHSDEEHLAIKTWNMLVQGNETWKENGMFPRVTLCDFETRDMGNVQTHTIQCLLLMNVFTEKIFLILWTWFMTLAAITALNIVSWSWSMMSETSQLHFIVSHLDMSDVTIDKNKMDQAEKVTRFLNLYLGSDGMLVLFLVSQHSDVVFTSELVAHLWKSFTDVEQQRIALKKMNKFVELQQKIASSSNQDANDAAIEMTPRMKRAMSLEKIENGESRKRFDDSSSDESKTSNVSKRKKSKNDSEVNSRNHTPRPIHSLPSSCFTCYHLFSLSSSQFIEIDLPFHPSPSDSSFPSMDFPRPMQRTCLVCNAKADSAHFGVASCRACAAFFRRTVLLSRNYICRQSTDNCNVSKEVRFTCRRCRFAKCLQVGMSPETLLFLKRVSITCVPIVNYRSADSDGGLGRMKSESESFSEAGTSQTFLLDVITEQYRLLEQISMRSDEYVMTEAFGDRLQSRNGHLPATIGMLNQCVRATHQPMIDFATICFPEIHDFNDDEKWLILKNFMTSRFLFDGVHLAQKFFPGNDKIFMMTFHTFIDIDQLDFYLSDLEALYDKQHSISIMREMTTKCTSDWLGPLLTRAGIDEVETMAIYGLLCWPSYLSNASTRVMETCYKYHLRIFQELHNHYKKTGHAEYSSRVAHITSILLCVQAAIQRLKEDMQIYRLLDVYSGNELVYNVYSARLPYLPMHLSLAGSSGSVSRRIPKIIVSKVLVSFKYPDADTVFQFGSLSSRSSSFAHSPTPASSPRSSTLSLNDLNSEKYLKVPRSPSFDVGVGLPSRRVSIDMGDAVGKRMMDSRNPGRSRLERSCSLNILPSLPEEPQDSAGTDAPNDCCFCQIVHSLLRSCICGAFIIALLIPIVMFFFYTLLFIPFTNTFNSMGQKANIEASIHNLFIHSIVNHLTVEETTNSTLPTELDYLQFASLVGL
The following text describes a protein:
Function:
Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines.
Subcellular Localization:
Early endosome.
Sequence:
MAAEIHSRPQSSRPVLLSKIEGHQDAVSAALVIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMSSPCSTMAYHHDSRRIFVGQDNGAIMEFHISEDFNKMNFVKTYPAHQNRVSAVIFCLEAEWVISTGHDKCVSWMCTRSGNMLGRHYFTSWASALQYDFETQHAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSIASLWWDPVQRLLFSGASDNSIIMWDIGGRRGRTLLLQGHHDKVQAVCYLQLTRQLVSCAADGGITVWNMDITREEAPQWLDSDSCQKCEQPFFWNIKQMWDTKTLGLRQHHCRKCGKAVCGKCSTKRSSYPIMGFEFQVRVCDACFDSIKDEDRTSLATFHEGKHNISHMSMDISRGLMVTCGSDRVVKIWDMTPVVGCGLATGFASR
The following text describes a protein:
Function:
FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation in the endoplasmic reticulum lumen.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein; Lumenal side. Cytoplasm. Nucleus.
Sequence:
MILNRRIQVILPTLLILSFIIWIFHSVMVDKDWRLFMPEIKSLPDREGQGRKPIEMMSTKHDNNTNNLMVNAYWKLIHTVVSNYPNRPTLDERDILRHYLFSSAITMPCGEYSVELQKILDVHPPQTSSRKAATTWACKVHNQLNEKMNQPKTSCDGFNERYVIGSPTYRESEAENVPERVQVINEDHDYSG
The following text describes a protein:
Function:
Probable phospholipase.
Subcellular Localization:
Secreted.
Sequence:
MIIFKNLLKLLIILLTIKLYFCIEIKREEHLTILNELNENSDVIQYSILPGNNEEYEIVKGIQEDAIVYGYYMSNVEVNGWAYLSLVSNDKYNDSTQSRAFGYLEGYLTKDLIWNSKVNYYKNAFNSSEIPNKLDDWLTENIESIHTFIVNNRKSRYWNQITLVMDQINGMLDGYNEANTNSSETLSLHDFFVLNMFGDLFDLMPALNLDKEYKYFQKDLNDIQDWFKRSQHCSALIKVSSDYSELYSGHTTWSGYYTMLRIFKSYNQQFSSDVSGTLSKRNIFSSYPGALISVDDFYLLGDTRMVVIETTNSLVTNDLYHLIRPTTVLSWMRVIVSNRMSTNGKEWCENFQRYNSGTYNNQWMIVSYNLFVPYNELKDGALYVLEQIPGYIEFSDQTQALRQGWWNSYNIPFYETIYDASGYNNYTANNYSDSTIYYMSYQTCPRAEIFRNFAGYVESLEDFQSLLRYNDFEYDPLSHKLPFYAIASRYDLSKKNPSPFGATDTKVTCNSMIDQNTIVAISGPTTSNGQPIFEWNSKIDFMESTSHLGCPEKYNFPWVSFSDTTFRNL
The following text describes a protein:
Function:
Absolutely required for transposition of IS1.
Sequence:
MVIPKLKALILKSFYGPLELPGFSDKCYSDRVIKNGSSRGKSKYKCKVCGRTFYRTASHRMSREQRERILREYTNRMSLRGISKVEGRPLTTVYSSVKRAALKAYVDLSILQAQLKAFRSKFAVLDESWTYVRVRRGPRRQNLWIWNALIDGVPFFVTGDRDYNTFRLLWLSLPKCEVHYTDDYPIYQVLYHHVVGKKYTHTVESYNSFCRSHLVRLARDTKAVNRSRAMIDYSLDLLNVMYPQAFTDEKTPLNLAYLSGVQYIRDHLI
The following text describes a protein:
Function:
May be an environmental sensor responsive to several stimuli, including internal pH, proton motive force, temperature, and possibly other unknown factors.
Sequence:
MAVSAKYDEFNHWWATEGDWVEEPNYRRNGMSGVQCVERNGKKLYVKRMTHHLFHSVRYPFGRPTIVREVAVIKELERAGVIVPKIVFGEAVKIEGEWRALLVTEDMAGFISIADWYAQHAVSPYSDEVRQAMLKAVALAFKKMHSINRQHGCCYVRHIYVKTEGNAEAGFLDLEKSRRRLRRDKAINHDFRQLEKYLEPIPKADWEQVKAYYYAM
The following text describes a protein:
Function:
Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSDARTQQADALIGELQREHGGRLTVFLGAAPGVGKTYAMLSRARERLRQGVDVVAGVVETHGRSETAALLDGVPLLPRVQVSYQGHALEELALDALLARKPQLALIDELAHRNVPGSRHERRWQDTVELLDAGIDVYTTVNIQHLESLNDIVLRITGVRVSETVPDAVFDRLRDIVLVDLPPRELIERLQQGKVYLPEQASQALQAFFSPSNLTALRELAMQTAADRVDSDLRDTQAARGLPGTAALRRHVVVAIDGRGSSDYLVRVARRLSERRDAPWTVVTVQTRTVADAAWQLEIDRAFALTRRLGGDTALLHGANVADALLDFASQNGVSTLVLGRTRERPLARMFNRTLTQQLLQRGAHYELVIVSSGDARARARQRWRNPGQWLQRYDLAYAAIAAAAAVAVAWVIQRWTDIDDLSMVFIVAVVLVASRTRMAAAVIAALLSFVAYNFFFIEPRFTLHISARQGVVTVCLFLIAALVAGRLASRLRSQVLALRAANAHANALQALARQLSTAADLGQVLEAGRRALASALDAEVWLRLEQCESEAPTSFSALDRNAADWTQRHGQPAGRFTDTLAGAQWWCLPVRHERGTLGVAALRFRQQLQRPGLEQRRLAEAMVEDIGQAALRTRLVADLEGARVSGETERLRSALLSSVSHDLRSPLASMIGSASSLAEYGEAMDATDRRSLLETIQLEGERLDRYIQNLLDMTRLGHTGLTLKRDWIGVDELIGSATRRLQRYQPQVRLQLDLAPELPAIWVHPALVEQAIFNVLENAAKFSPPGVAVTVQARLQSGALQIEIGDQGPGIPEDERARIFDMFYSVERGDRGRHGTGLGLTICQGMIGAHGGSVEALAGPHGHGTTIRITLPLLVPAASPRPDAD
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
Sequence:
MAERELYIGVMSGTSLDGVDTALVALQDDNIELLAHHDYPIPADLKQRLLNVCIGQPTTLIAMGELEHDLGHLFSDAVLALLQHSGYRAEHIRAIGCHGQTVFHQPTGTKPFTMQIGDANIIATRTGITTVADFRRKDVALGGQGAPLVPAFHRTIFHAEQSTVVVLNIGGIANISVLKPNGEVVGYDTGPGNMLMDSWCQKERNQPYDKDALWAKQGSVNAALLSHLKQDHYFALPAPKSTGRELFNLPWLETQLATFSVDATDVQRTLCEFTAQTIVEQVAPFAEGPQPQLLVCGGGAQNPLLMERLQALLPSWQVAPTTQMGVDGDNMEAMAFAWLAQRRIHGLPSNLPAVTGASRLASLGVIYYPD
The following text describes a protein:
Function:
Transcription factor that controls the expression of genes related to the process of conidiation and adherence and regulates biofilm formation. Controls conidiation and adhesion primarily by affecting the expression of the three regulatory genes flbB, stuA and medA. Required for virulence in an egg and a mouse infection model.
Subcellular Localization:
Nucleus.
Sequence:
MNQMNVTGMNPGAGGPVGGVPMMNNGSTAPRNDGNVNNIPETMINNLNTYIYDYFLKRGYHECARALVKDESIKLNTEPPTKTSPGHRREDMNGVEGDAIMTDSKDGDKIKIPDDLPRPNLASESQQSSFLLDWFSLFWDFFWAQRKKGNSNDVRQYLQHTQNMMRLREQQHNQLLRQQPVMPRQMGPLNMRRNGMVPANLQKTVLQNNTGGLSQQQIAQLQKNQQMHMMQQMQREHSDMDMNGHRPQSPSSAENAPSPSKRPRLENGPMNGQQLAPNGRGQGQAMPGQPNSQALLMQNGLNPRAMNPAQFAGFQQQGPAAQQKSIQVYAQNLALHHSRSALNNQGIPNGLMNPGVMPNQTDLVPMPDGQGMYPMNGDYYGTNGQMAQVRAGMQTPGGQHGNHALQDYQMQLMLLEQQNKRRLMMARQEQDSMSRADGQPPMPGQQGLPPGTSPQGSRAGTSPNPNEQMKRGTPKMPQTGLPGSPNAADAMGQNRGSPAAMNFNGGQMPPDMAGGQFFMKGMPDAMGGPNGMRPPSSNPAFSGPQMGQPIPAGAVNRVPSGNWQQQQGQPMGPQQSPAQQPQSTGTPQTQNSMPPPQAPPAGANAARTSPQSQNAAPPTPQQANKPAPKKREPKDTARKRTTKKQPAAAAAAANTAATPSSEAEHPPTTPTPSTPITPQHPSSFNKAGPNPTTSAPQQPTSAPAPQPIVQQPPPDQTQQSFNDLSIPDASAFNLDFSALENPDILENFDFDTFLNTDADTAGFGFDPNISYPTDGVETGAGDGL
The following text describes a protein:
Function:
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.
Subcellular Localization:
Cytoplasm.
Sequence:
MNLKQSIEEIINQPEYEPMSVSDFQDALGLSSADSFRDLIKVLVELEQSGLIERTKTDRYQKKHSYRGQSKLIKGTLSQNKKGFAFLRPEDEDMEDIFIPPTKINRALDGDTVIVEIHQSKGEHKGKIEGEVKSIEKHSVTQVVGTYSEARHFGFVIPDDKRIMQDIFIPKGQSLGAVDGHKVLVQITKYADGSDNPEGHISAILGHKNDPGVDILSIIYQHGIEIEFPDEVLQEAEAVPDHIENTEIKGRHDLRDELTITIDGADAKDLDDAISVKKLANGNTQLTVSIADVSYYVTEGSALDKEAYDRATSVYLVDRVIPMIPHRLSNGICSLNPNVDRLTLSCRMEIDASGRVVKHEIFDSVIHSDYRMTYDAVNQIITEKDPNIREQYNEITPMLDLAQDLSNRLIQMRKRRGEIDFDISEAKVLVNEDGIPTDVQLRQRGEGERLIESFMLIANETVAEHFSKLDVPFIYRVHEQPKSDRLRQFFDFITNFGIMIKGTGEDIHPTTLQKVQEEVEGRPEQMVISTMMLRSMQQAHYDDVNLGHFGLSAEYYTHFTSPIRRYPDLTVHRLIRKYLIEKSMDNKEVKRWEDKLPELAEHTSKRERRAIEAERDTDELKKAEYMIQHIGDEFEGIVSSVANFGMFIELPNTIEGMVHIANMTDDYYRFEERQMALIGERQAKVFRIGDTVKVKVTHVDVDERLIDFQIVGMPLPKNDRSQRPARGKTIQAKTRGKSLDKSKSDDKGRKKKGKQRKGKNQRNNDKSGNSKHKPFYKDKSVKKKARRKKK
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Subcellular Localization:
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Domain:
Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
Sequence:
MPINESSVKYDIEKLQGSRIKVNVEVDAREREESLERAYKSLVKRYQVPGFRKGYTPRPVLERYLGIEAFEDEAIRIVAREVLNMILQNENFTPLQDPYFDLLPQEWKENENLKFSFVIEVPPEFKLGDYKGFGLKKEKVEVSEEEINRVIEQIELQLSKLNTVEEGSIEKGDVVYLEREREDGSQLPPLWFTLNGQMLPELEEKLIGMKPGEEKVIEISFPEDFYEKELAGQSLPLKWKVKKIWRYEKPDQEIFLQKVNASSIEEFREKVRESIKEEREKLEEDKLFSQILDKILENTELDPPLSYVHYLAENILREFLTELNKKGVQLEDYLSQRGISKDEFVNNVIEDARKRIKIEMILDKIAEIENINISDEEINNVIKEIAENEGKEFKEIKRELEREGTINTLKRNLLREKVREFLIKENVVEEE
The following text describes a protein:
Function:
Magnesium chelatase involved in chlorophyll a degradation in the chlorophyll-protein complexes of photosystem I (PSI) and photosystem II (PSII). Contributes to the degradation of PSI and PSII in the thylakoid membranes. Recombinant SGRL possesses high dechelating activity against chlorophyllide a, very low activity against chlorophyll a, and no activity against chlorophyll b. Contributes to abiotic stress-induced chlorophyll degradation and leaf yellowing during vegetative plant growth.
Subcellular Localization:
Plastid, chloroplast thylakoid.
Sequence:
MACYIVPYYHHPVLSHPNREIFSHRHHHHHRFCNNLLNRRISVPRSSAISDGGVSYNTLVSEAVRLLVPQANFDSSKLKVEFLGELLENKSNGGIITPRTYILSHCDFTANLTLTISNVINLDQLEGWYKKDDVVAEWKKVNDELRLHIHCCVSGMSLLQDVAAELRYHIFSKELPLVLKAVVHGDSVMFRENPELMDAYVWVYFHSSTPKYNRIECWGPLKDAAKGKQQGNHQGFLSSTTSRKLIRHKSIFHTLFTFLL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSRRKQTNPNKVHWDQVFAGLEEQARQAMMKTEFPGDLGSQRQALQHLRDQDSSSSDSEGDEEETTQDEVSSHTSEEDGGVVKVERELDSAEAPVGSGDALVEHEVTENLNSDPLLELCQCPLCQLDCGSREQLIAHVYQHTAAVVSAKSYMCPVCGRALSSPGSLGRHLLIHSEDQRSNCAVCGARFTSHATFNSEKLPEVLNMESLPPVHSEGPSSAEGQDIACSPPVYPAGILLVCNNCAAYRKLLETQTPSVRKWALRRQNEPLEVRLQRLERERTAKKSRRDNETPEEREVRRMRDREAKRLQRMQETDEQRARRLQRDREAMRLKRANETPEKRQARLIREREAKRLKRRLEKMDMMLRAQFGQDPSAMAALAAEMNFFQLPVSGVELDSQLLGKMAFEEQNNSSLH
The following text describes a protein:
Function:
Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate. Also displays malyl-CoA thioesterase activity. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate. Also has very weak citramalate synthase activity in vitro.
Subcellular Localization:
Mitochondrion.
Sequence:
MALRLWQNVCRAAAAGAATAARAGAGGTAGLLGNLKVSLAVNVLKTGYCSSVNHKYIPRRAVLYVPGNDEKKIQKVPSLNVDCAVLDCEDGVAMNKKNEARLRIVKTLEEFDLGPTEKCVRINAVSSGLAEQDLEALLQSQVLPSSLMLPKVENPEEIRWFSDKFVFHLKGRTLVEPMNLIPFVETAMGLLNFKAVCEETLKTGSRAGLHLDAVVFGGEDFRASIGATSSKETQDILYARQKIIVVAKAFGLQAIDLVYIDFRDEDGLRRQSKEGAIMGFTGKQVIHPNQIAVVQEQFSPTSEKIKWAKELISAFKEHQQLGKGAFTFHGSMIDMPLLKQAQNIVTLATAIKKK
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
Miscellaneous:
MISCELLANEOUS: Present with 1240 molecules/cell in log phase SD medium.
Subcellular Localization:
Endosome.
Sequence:
MGEQNKLYYDVEKLVNSLQESFDLDCAQSVSLFTSKSRSNEAWLEELENKFKLKDDVELDDVENLRAEIDMKLNMLEDKVSYYERLYKELEEFQNEIKIKTVVNNRRQSRTPK
The following text describes a protein:
Function:
Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7).
Sequence:
MNNMKLQLMYSFLRSDINVIEKELKKTVASEQPLVEEAALQLIEAGGKRIRPVFVLLAGKFGDYKLDAIKHVAVALELIHMASLVHDDVIDAAFLRRGSATVNAKWGDRIAMYTGDYLFAKSLECITNIEIPEAHQALSHTILEVCKGEIEQIKDKYNYDQNLRTYLRRIKRKTALLIAASCQLGAIAAGANRDTVNRLFWYGYFVGMSYQIIDDILDFVSTEEKLGKPAGGDLLQGNITLPALYAMEDPVLRQKITSVHENSTASEMQEIIDAVKNSTAIDQAFAFSERYLHKALEIIKPLPRGKAKYALQNVAKYIGKRKF
The following text describes a protein:
Function:
Catalyzes the dephosphorylation and concomitant reactivation of the E1 alpha subunit (PDA1) of the pyruvate dehydrogenase complex.
Miscellaneous:
MISCELLANEOUS: Present with 7550 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion intermembrane space.
Sequence:
MSPLTRTVAIKKTVKVLSKCQSGREYTQKFLQRAYSTSHANSTYYSRTKLFISSHSKALNIALLSGSLLLTYSYYSPKKILSLDTINGIKDYSTNTSGNINMPSPNPKGTETQKSQRSQNDQSVLILNDSKIEAKLHDREESHFVNRGTGIFRYDVAQLPSNHPIEDDHVEQIITIPIESEDGKSIEKDLYFFGIFDGHGGPFTSEKLSKDLVRYVAYQLGQVYDQNKTVFHSDPNQLIDSAISKGFLKLDNDLVIESFRKLFQDPNNTNIANTLPAISGSCALLSLYNSTNSILKVAVTGDSRALICGLDNEGNWTVKSLSTDQTGDNLDEVRRIRKEHPGEPNVIRNGRILGSLQPSRAFGDYRYKIKEVDGKPLSDLPEVAKLYFRREPRDFKTPPYVTAEPVITSAKIGENTKFMVMGSDGLFELLTNEEIASLVIRWMDKNMNLAPVKAEPGKLPKVIDVSEDKEAQRPAFRYKDNNSSSPSGSNPEYLIEDKNVATHLIRNALSAGGRKEYVSALVSIPSPMSRRYRDDLTVTVAFFGDSGTPSIVSNATSIVMNPEATTKPKPRL
The following text describes a protein:
Function:
Metalloprotease which, together with cadherin cdh-3 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development probably by promoting the degradation of the basement membrane separating the gonad from the vulva epithelium.
Miscellaneous:
MISCELLANEOUS: Displays very low catalytic activity compared to zmp-2 towards synthetic substrate Mca-Pro-Leu-Gly-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 in vitro.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane. Note=Localizes to puncta on the cell surface that are often concentrated at the invasive basolateral membrane of the anchor cell.
Domain:
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence:
MFTGLHDILIILFLLVTLKIAQNVDHTKFLQKYGYLTSGDNQLSSESLSDALKNMQRMAGLEETGELDERTIQMMERPRCGHPDVEDHQKSRGKRYAPPQFKWKEKIITYGCKAVGTSTRISLDDLRRTMHQAASQWSELADVEIVESSVKNPMMVISAGRENHYPCTVRFDTKTLAHAFFPTNGQIHINDRVQFAMTNYTERMGANSLYSVVAHEMGHALGFSHSPDIDSVMFAYDTPRKWKFTSMDKYNMRSYYGAKASKKENEEEERKTENEDKRRKTEKDRGRTREHESDDIRPNECRVENPIVVQYRGEYLIFKSQWVWRVSSDWKRLIIKAVPINQLFPGLPNPIDAAVTVGHNLWVFVGEMIYVIYGNHMVHAPLRLSDIGINEKYVDLAYEWHYFNPPAVYIWKGSRYWKLDEKMYHRRVDERYPKDTDLNWARVPKGVHSAFTYEKEIHLLRGNQVFRMNSSRSVFDIADGYPQPLQSFFGFCPRNEKLVLNSSSSHFSLIYATITILILIF
The following text describes a protein:
Function:
Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein. Required for the formation of complete GPI precursors CP1 and CP2.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPAKKRTRKTVKKTVSFSDDTTLTTHQNREKKNVDHDRPPVYVRKTPLMTFPYHLVALLYYYVFVSSNFNTVKLLSFLIPTQVAYLVLQFNKCTVYGNKIIKINYSLTIICLGVTFLLSFPTMLLTILFGAPLMDLLWETWLLSLHFAFLAYPAVYSVFNCDFKVGLWKKYFIFIVVGGWISCVVIPLDWDRDWQNWPIPIVVGGYLGALVGYTIGAYI
The following text describes a protein:
Function:
Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.
Sequence:
MVPTSIPTTQLKDGTSIPVIGYGTGTAWFKKKGDTSINRDLVESIKTAIRLGYHHLDSAEVYGTERELGVAIKECGVPREQLFVTTKVNQNIANVPKALEDSLEKLQLSYVDLYLIHQPFFAESPTELQDAWAAMEKVKEAGKARAIGVSNFLESHLETILDSARIPPAINQIEYHPYLQHGSLVPYHERKGIAVASYGPLTPVTRAKGGPLDPLLSELAGKYGVGEGEILLRWSLYRGAVAITTSGKESRLSTYLNVFKFQLTHEEVLKISRIGDQKHYRGFWSDKFAADDRS
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MADFSAAFNSVPPVTRTILIGLGAVTFPCLLGLTSPASVALLWRRVTQGYEIWRPLTCFFFGGGGFPLLYDFFLIYRNSSSMEKDTYLSNTAEYAWLHVVMAIFILIFNMFVGLPFLFRPLLHAQTYVWCRVNPTVKVSIFGLLTIPTSLYPVALIVLDLLTGGPLKAISGVMGLLAGHLWWFLSTYLPLYAPSHLRRQNPLATPSFFKSWFINNSSNRRTFQSVGTSMQAQTSFATSSSRSEAAQEARHRWGGGQRLGGSTL
The following text describes a protein:
Function:
Functions in a MAP kinase cascade that acts as a molecular switch to regulate the first cell fate decisions in the zygote and the early embryo. Promotes elongation of the zygote and development of its basal daughter cell into the extra-embryonic suspensor. In stomatal development, acts downstream of the LRR receptor TMM, but upstream of the MKK4/MKK5-MPK3/MPK6 module to regulate stomatal cell fate before the guard mother cell (GMC) is specified. Plays a central role in both guard cell identity and pattern formation. This MAPK cascade also functions downstream of the ER receptor in regulating coordinated local cell proliferation, which shapes the morphology of plant organs. Upon brassinosteroid signaling, is inhibited by phosphorylation of its auto-inhibitory N-terminal domain by the GSK3-like kinase ASK7.
Miscellaneous:
MISCELLANEOUS: N-terminal deletions of YDA results in gain-of-function alleles with phenotypes (no stomata and exaggerated suspensor growth) opposite to loss-of-function phenotypes.
Subcellular Localization:
Cytoplasm, cell cortex. Cell membrane. Note=Recruited by BASL at the cell cortex in a polarized manner.
Sequence:
MPWWSKSKDEKKKTNKESIIDAFNRKLGFASEDRSSGRSRKSRRRRDEIVSERGAISRLPSRSPSPSTRVSRCQSFAERSPAVPLPRPIVRPHVTSTDSGMNGSQRPGLDANLKPSWLPLPKPHGATSIPDNTGAEPDFATASVSSGSSVGDIPSDSLLSPLASDCENGNRTPVNISSRDQSMHSNKNSAEMFKPVPNKNRILSASPRRRPLGTHVKNLQIPQRDLVLCSAPDSLLSSPSRSPMRSFIPDQVSNHGLLISKPYSDVSLLGSGQCSSPGSGYNSGNNSIGGDMATQLFWPQSRCSPECSPVPSPRMTSPGPSSRIQSGAVTPLHPRAGGSTTGSPTRRLDDNRQQSHRLPLPPLLISNTCPFSPTYSAATSPSVPRSPARAEATVSPGSRWKKGRLLGMGSFGHVYLGFNSESGEMCAMKEVTLCSDDPKSRESAQQLGQEISVLSRLRHQNIVQYYGSETVDDKLYIYLEYVSGGSIYKLLQEYGQFGENAIRNYTQQILSGLAYLHAKNTVHRDIKGANILVDPHGRVKVADFGMAKHITAQSGPLSFKGSPYWMAPEVIKNSNGSNLAVDIWSLGCTVLEMATTKPPWSQYEGVPAMFKIGNSKELPDIPDHLSEEGKDFVRKCLQRNPANRPTAAQLLDHAFVRNVMPMERPIVSGEPAEAMNVASSTMRSLDIGHARSLPCLDSEDATNYQQKGLKHGSGFSISQSPRNMSCPISPVGSPIFHSHSPHISGRRSPSPISSPHALSGSSTPLTGCGGAIPFHHQRQTTVNFLHEGIGSSRSPGSGGNFYTNSFFQEPSRQQDRSRSSPRTPPHVFWDNNGSIQPGYNWNKDNQPVLSDHVSQQLLSEHLKLKSLDLRPGFSTPGSTNRGP
The following text describes a protein:
Function:
Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (By similarity).
Subcellular Localization:
Basolateral cell membrane.
Sequence:
MTDPGCPERRTLCFLSTLLSQKVPEKSDVVLRCMIAGQPKPEVTWYKNGQAIDLGGTVSSYEFFENQYIHLLHLSCCTQSDAAVYQVSARNCVGMICCSASLEVQCLQDPQVSPDPGGGRDAAGECKTEIREEDSINHTDEKWNPCKKGESTADSFLDKFNHLSSPQIVARGDSGASNSENPQYIKETRQRMGQYNSNNMQENSFNSNNTAEKQDVSQLWTVNATVPGLVSDGLGYEESNESVSPSHQTPKVQKYISFSLPLPETTLGPYPEDSNSINMQPGPQVSSEDSDSDYELCPEITLTYTEEFSDDDLEYLECSDVMTDYSNAVWQRSLQGTDRVFLLESDDEEMEFNECGLGGCEHFFTEMGCGPQVSGGMWSMNVATGFCSYHSQPQEVRVRSSGTSGHSPLPLHSEMTLTLGPHQDETAKMTEPGRAPLPTAPEAVENDCSGIRGETRDNPEAGEEFSGDNLQTMDKVETEASVKPLSGGSDKTEVKQGLESLARERTDEKYPGSKKAALRPTRARRPGMKANTKKQLLRDSAPKGTLDLLPKEPTRQPLPGSYGQEPTHTEAGAPGWDSHFHAEVCIPLPAEQDSKILRPPADPLSKEEDSSFEGGGALLNKLFEASQIPDRTDHLQMQIQETIGESSSLDQMLAFSVPAEESSTFAGATTHSVSNLSEINRENLSLAQYPGLESCPQSLQQEGRPNRDRDLPGALWAESACELSLLEDNEEEESQPPASVALPQGDGVPCREPEGLSDSFPQPTAPSLPLENVGSGSRVREAAGGVGCFEAGDQETCYATMDLLVGAPVDKYLPQEICPEDLELTEGQSEVCDLCSPDKILAVLQTQGSEPPRSTDKRSQDGKSAEGLLFNSTFTWDTAKEASEDAVGETAADVENPPSTFSSTLPYSERGFGETQPLCSETISFVKDSEGSYRSSSLSIPAAIDTLASYSSDRECSKEQSAESTANVDCHQVTREMEGISTNAAEVHEIKCHSVSVPQDNDFDVGADQVSCEARDEDNSQSLPDDDSQSGRSLSSSTGEATGETLVPAPSSAGDHGHFSMPEGQGLCSRALQMDNQPVCQSQAMEGAHSRGLEEHFQEKGSGMKHGIRPQSTSHQVSLSANDFQEILPSIPTMQQETNVEPLEHSLADSREEIECSSDPRTSDLVVAEKTVGEDSHLVVSVPALPDILLGEKDDVGLGSWAVGGKVKIITLEAPVFEIWPPELVRHPGYKEAEAGLTMPGRSWALSDILRAGATRSEPGALGGAAWVPSPQADALMALGANRDTWLGAAPDRQANCNCLSSQCLSQPRFLESSVDPVEDKELEVTDSPSEVSKTGEMEMPETLNEEQEETQQILRHPAVVNQSVNFPRILESSVDPIDDRGELEGVWPEKPEPSDSSVEGNEFIVGNTCQRVDIQPASLQLPHPQDSGEIIPYEHTTNQNRVDGERAEAKTSLPDKAKAEAEAVVWQAQGPGEEGQGIPSVCSMSQTQDGGDRSLGEAGQRGTDETEVISPLSPLSSCLTGVTHTCVKAETNNSTGHIYGGSEPRTRQSVIPMKTEKGTIESKCGNHVRSSDDLTNTPCTSSPKGNVTRLSISHGLEELKSEKLQIAETKPLNSSDSPTMTLALISGECESEKDPKSLLRRDPCPKGSTLDSGKKSRDQQQKPVAAQVSKAPGDQSAMAGSEEGKKKQEASGSGHLTAGIKKKILSRVAALRLRLEEKENSRKNSIVKKTPKFERSLSRTDEKRDPKRAPCKAEGKAPVLLKRIQAEMAPEHSGNIKLSCQFSEIHEDSTVCWTKDSKSIAQAKKSAGDNSSVSLAIVQAGQKDQGLYYCCLKNSYGKVTAEFNLTAEVLKQLSSHTEYRGCEEIEFSQLIFKEDVFNDSYFGDHLRGQISTEELHFGEGVHRKAFRSKVMQGLMPVFQPGHACVLKVHNAVAHGTRNNDELVQRNYKLAAQECYVQNTARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRDSEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATLARGYKGFKGNCSMTFIDQFRALHQCNKYCKMLGLKSLQNNSQKPKKPIVGKGRVPTNATQVKTPESETPPAERKT