lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum.
Sequence:
MAKWGEGDPRWIVEERADATNVNNWHWTERDATNWSTDKLKALLLGLSVENEEGTCEVTEVSKLEGEASINNRKGKLIFFYEWNVKAAWTGKSKTGVKYKGTIEVPNLSDENDMEDLAISVMMNKDEPDTPLLSLMKTKGAEKVRQALGSYVDFLKTEFTQGMILPTANGVAKVPSASQSKAKLDKTQICSGGSSSSAAAPANAGVKIPTCKFSIRDTFLTSPADLYRVFVNQEMVRAFTHSAAAVEAERGGRFRLLDGNVCGEFTELVPDEKIVMKWRYNTWPCEHYATITLTFVDRSSETELKVECRGVPNSEEEQTKEGWRRYYFEAIKQTFGFGARLF
The following text describes a protein:
Function:
Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of a single 3-deoxy-D-manno-octulosonate (Kdo) residue from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Is strictly monofunctional, i.e. is capable of adding only a single Kdo residue to the acceptor lipid.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein; Cytoplasmic side.
Domain:
The N-terminal half of KdtA, especially the first 30 amino acid residues, is responsible for determining the number of Kdo residues that are transferred to lipid IVA.
Sequence:
MWRFFYTSLLLICQPLILCFIGLLSVKSPRYRQRLAERYGFYGNASCPPPQGIFIHAASVGEVIAATPLVRQLQQDYPHLSITFTTFTPTGSERVKATFGDSVFHYYLPLDLPFSIHRFINFVQPKLCIVMETELWPNLIHQLFLRNIPFVIANARLSARSAHRYGKIKAHLQTMWSQISLIAAQDNISGKRYATLGYPKEKLNITGNIKYDLNTNDELLRKIDSLRTLWKQDRPIWIAASTHNGEDEIILKSHRALLAKYPNLLLLLVPRHPERFNVVADLLKKEKFQFIRRSTNELPNENTQVILGDSMGELMLMYGISDIAFVGGSLVKHGGHNPLEPLAFKMPVITGKHTFNFPEIFRMLVEVQGVLEVNSTADALERAVEALLNSKESRERLGNAGYEVLMENRGALQRLLDLLKPYLERNV
The following text describes a protein:
Function:
Involved in biosynthesis of legionaminic acid (5,7-diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into virulence-associated cell surface glycoconjugates such as lipopolysaccharide (LPS) which could be a key determinant in the ability of L.pneumophila to inhibit the fusion of phagosomes with lysosomes. LPS contains a majority alpha2,4-linked homomer of legionaminic acid. Catalyzes the conversion of UDP-N,N'-diacetylbacillosamine (Bac2Ac4Ac) into 2,4-diacetamido-2,4,6-trideoxymannose and UDP.
Sequence:
MIRKIIYVTGTRADYGLMREVLKRLHQSEDIDLSICVTGMHLDALYGNTVNEIKADQFSICGIIPVDLANAQHSSMAKAIGHELLGFTEVFESETPDVVLLLGDRGEMLAAAIAAIHLNIPVVHLHGGERSGTVDEMVRHAISKLSHYHFVATEASKQRLIRMGEKEETIFQVGAPGLDEIMQYKTSTRDVFNQRYGFDPDKKICLLIYHPVVQEVDSIKIQFQSVIQAALATNLQIICLEPNSDTGGHLIREVIQEYIDHPDVRIIKHLHRPEFIDCLANSDVMLGNSSSGIIEAASFNLNVVNVGSRQNLRERSDNVIDVDVTYDAILTGLREALNKPKIKYSNCYGDGKTSERCYQLLKTIPLHSQILNKCNAY
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MKFNFWKGLWKPKSLTPTLSHRLYRRMYTPQPPLNREMTVLDRSKFTVSLNLALAKFPDPKYIAQFAKECKADILQLRSINHVQKTDDNGRAVLLRHDLDLEGGEDVASKVMSQLSPRGKELLTEAQADITKIVKDLDYDFWRADEIFYSVLPVTEKDEIPSGFSMVGHVAHLNLRSEWKDYDRLIGQVILDKNPRVKTVVNKVDSIDTKFRTFKMDVLAGEDNTEVEQHESGCRFQFDFAKVYWNSRLHTEHDRLVSLFRGEASSRERKQQERAKRENHEKSTETAVEPDNTPATAVCDVFAGVGPFAVPSGRTSLFVMANDLNPYSYEALEHNVKLNKVSEYVKCFNLDGAEYVQQSMKLLDEHRRTQPTINPVQVRKRKAGQPVVKQDIPNHYSHYVMNLPDSAIEFLWSFKGLYTTVDGLSQDTPLPHVHVHCFHKWEAGEEEPSKEETKAALLERVYKQIDVRLDPNEVGMHWVRKVSPKKDMFCISFELPKEVAWAPQVNKE
The following text describes a protein:
Function:
Essential for normal crossover (CO) formation during meiosis. Essential component for the formation of class I meiotic COs. Interacts with PTD, another meiotic component, to regulate CO formation, possibly by stabilizing the recombination intermediates during meiosis. SHOC1 and PTD may form transient heterotrimeric or heterotetrameric complexes with HEI10 and/or ZIP4 to promote class I COs formation. Does not seem to be involved in early meiotic recombination steps involving double-strand break (DSB) formation, processing, and single-strand invasion. Does not seem to be involved in homologous pairing or synaptonemal complex (SC) assembly.
Subcellular Localization:
Chromosome. Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localized in the nucleus. Localized in punctuate foci onto meiocyte chromosomes from leptotene to early pachytene with a maximal number of foci at zygotene.
Sequence:
MRTRFLATDYFAPSSSSAAGKALALEFFSFPSLPVPALPPDPHFLPFTSADELPAATVADDGLGPLPIASALSDFLAAVIPQALPVPTVPAADEVLDDFLYDRGGYGEDFSSWEFGAFRIPKASEGYGVINREKDEKGEGSRSDGLEISSVMKRWEQLKELRFEVVEVDLLMALQEDIASFGEEESGGGVTLLLRVPDMKIHLDFIDIETDIKIRYQSDLPESVYQVEKVPVKDNDGNGHSSLREDCCLEIAALDHGAVIPRLEVSRNSWELDDCLTETDRYGVFDNVVRHLDEAQIQHSVFKSTEFLRSTDMDMLTFVCEDAPCHDIQVDKPAEIKAAVEMDVVRINGNILLEKNSALYPLKPDGTCSDLPCSILLEEVQIIDFPSDNVFKMLVQSETNKMNISDEIFKDDFDPARRLYESMVSCELALVDDTFRSLPTPILNDDIAVRSRVPPIQEILCSLKPHPLSASDGIYLDWHLLLEGPCNREICCSYASMVEEAKTCHLSSELQRSCQSTSVFVSDFLEDFQRSPKLQDEDKHSDIYVPAPLSHDPQKLEATQKCEQEGGTRNHSSMKRPSPEKSSSFPELISHSGDLNFYLNVRSATKSGTNNENTSTLDVPHSEEQALSLSTRAKVDKLIEIHPVSPSNLIQGLIEQIHASYTSALQESTYWRHSFSDEQGLGISKQKLLELITGEGSEGSYNHCEHKDKMELIVLYALKQVAYYLCFFGLHAAHLYISNLTRSLENTPERLKHILWSISEAQRKSERQLFESHPSLSCIETILRSNKQIDQKILIVADRAFWLPLGQKLASMRMTFVEFGQNPATTFVDLVNKTNSTAWVLEELLKSDCILLDNKNIPASFPFDKFGIILEYGGPNKSSTLLSLAPKLDGLPPLHFLYVKVDGKDFPAALVEDNHKDQDLKSTLDKVLLTLQKDLQERMNKMRIVDSLNFIPATNQLQGLQEKRSKHFAADATKELLPDDQPHRLQNLNKKNTFDSHNVVLADEQLHIQQTLSNKPVVNSQCVPTVEKSSSTSSVSANVLKDPQENQSTTDLPSCVKNDCIMPGRLSVPDVVIVVNTGNHGKTMLVSRRSSYQQILALEKGGMQVVERDIDLPVDLILSAAVCLVWYETALFEANELTTSAETSGIKENVENIATNILMSVSFSFTGCIMVFEGEADFLSAVMDSSDSLYTAAASLDMNLQLFFSHTPRSTDEIILNCITNVTSCYKAPLPDIPESESLAESFLTSFPSINPVSAYMLLSSGGSLVEFLSWPHERRIQAVGKYLLSPKIISLFNALCKFGELGESRSVMTECSSVDSDISSAFLQSPRKRKQRSLQACAVPTNKLLFSDSLNQIPGDYAEHAEVFSPSKLRKFSDMDNTIPELPDVFTFDESLNMRSEGFSYQQKKHDVDAIPGNQVINDDFSNGLTPNNQAYNRRTGNMVDTFDLPWQPEFGGTHPSKSTFHTSRPSCSRTHSNPVFSTAFEINDDPGEWNISGGTKQTWKGLAHGGTVDDSYRYDMDNRYHEPRDEIMQHPASSLAFQKLDFGSHATSQGSCWEIDYLRQMSAKRKARQERSRCSNSPGMSIPRMRDSNSKILNPPPKESFRYRGDRDTPSRDQSPSIGTQHYGKGKEGAKAQNRRARKDFNVQPTSHKKRIEPSIDPTWTPIDKRARQKLSFVTYGKEKQSKLVWRNQNSPGVGCGFRKRFREEGT
The following text describes a protein:
Function:
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.
Subcellular Localization:
Nucleus.
Sequence:
MVNQRAKDTYLSPQARVAGEKEEAEEYGPTGFGDIGKYIVNKERKLLNADITLRNNAIAAAKEQGKEVPQLFKDCVVYVNGYTRPSANELRRMIVIHGGVYLTNLHLSGKTGVTHIVASNLTKKKKLEFQSYKVVTPDWVVDSVKESKVQDWAKYRLIVDTGNKNVLGLFKAKMATESFQELLDEELGDGGDLTQSLPTIEEPTKCSIIPSSLASPAHSMKPPVSKEPVALFPRPSLARKAERAPSVESPAPKRAKPIPSFSSFELSFDEEELFNSLPRPGAKGESESRTMGTQETQTQEGTDKTEETQEETRGQTEDEARYETVTTADNDVPISSLPFSSSMLRAVDQSIDAVKAEDANYDDLEFSQSELLGVLSQVGDGSVLEQALETEGEIQVDKGEPPDQLEDSDFDFLDHISAEESADESEKEDPAVERLAKEESSGRSVTPPIRPEDQLSTTPIKRTSKLPYAIDDPRFISHFYEKSRLHHLSTWKARLQAKFELSSKNKQVPPPISGGDRIIMHLDFDSFFVAVSTLDRPDLTRKPVAVGSGGSRNADIASCNYEARKYGVKNGMWMSRALKLCPDLQTVDYNFPKYEEVSEAFYTILRESQLDYIRPVSVDEALVDATTLIEANATECSLSEAAETVAKAIATKVRATTGCNISVGCSRNILLAKLALREAKPNGVHVMFDQKAISQLLDKTKISEIPGIGRSIAGQIREKLHVSTAGKLARLKDVIPNMSALLGPKRGPQIVDFCLGKDDSQIAVQDERKSISVEISYGVRFENKKQFDGFVFNMSAELASRMEEISVEGSQLTCKLYVRKNEHETPKYMGHGQCDIYNKSVSLGCSVSSTSEINLAARGQFAAMGYDPVLVRGVGIQITKLTRDKGKGKQSMLDFNRGRTTRPDLRAPIMPPAGTQFDIPADIDPEVLPFLPASLRKQIETRMGITGGSRGALDPPKTPTKKNQQEMGSFFSPSPSKSVYATPGLSQSSPIRAPSISPSPRRAKSVSPRKRPGKPAAKTQIKRQKANVRISHLLPDVQVCSEEMAALQNELAILKAALGEGTPVELVTRMMPLVNSQTDMNIFMELSSSIQQEVIMDYRNEIQRKIASISRQLEDLKEKERIERSREGSNLRTISLGTVTRNRPDTQELLSRLSQWVKSSYDGPHEDDVTHMIRRLRHYRNEGYHEVVNASVRWLSKLSAKSPDWSGVVRDIIVGLQEG
The following text describes a protein:
Function:
Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration. Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation. Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation.
Subcellular Localization:
Cytoplasm. Golgi apparatus.
Sequence:
MASCPACTEQGSPRAPCPQGLGLSCLGMSILGEKVAPGTFVRFCHPHHDPEALGKGVPHPYPGDTERSYGPPPPEWMGIAVGAPTPRPCPPPGDPSRWVRRLHGHIPGDALENRSCSNHPLRRPPPWVPPRGWHLPSGIHRVPRDVLRGAPSPSHCVSSPALPFLGDAPRGRPSRSHSTMSLSARPQRRVLVAKINRSQSFAGVNSTAERPFSRNLSPFTPTVSRKTGSRVSRMFSMSHKSPPPKVPQPNRLDEVYEALKKGLTAYLEVHQLELEKLSTQIRESKRNSRLGFLYDLDKQVKSIERFLRRLEFHASKIDELYEAYCIQRRLRDGAHNMVKAYSTGSPGSREARESLAEASKGYKEYTENMCLLESELESQLGEFHVRMKGLAGFARLCAGDQYEIFMKYGRQRWKLRGRIEVNSKQVWDSEEMVFLPLITEFLSIKVTELKSLANHVVVGNVSCETKDLFAALPQVVAVDINDLGTLKLSLEVTWNPFDKDDQPSAASTVNKASTVNKRFSTYNQSPPDTPSLREQAFYNMLRRQEELENGTAWSISSESSDDSSSPQLSSSTRHAAHKPIVQPEVQASAPAIEISFSQQQEETGAGGGIPAGTDLPGPPEEQDGRRKDAVANGHVPYTRTLSHISEASVDASMEAKATESPWEPSPSLEEHDVGKLDDDSLPGASNSVPETWAGKDSGPEAKPRAMVAWAATCEVEAEAAASHAAAQDVCGSEAPTPAVVLAQAPAEEGHVPAPHLATSPPAVPRVKAVDSGLEEAISLLASALDDYRGQFPELQPLERELKHLEEILLHKQGVFLSRASSISLTVEHALESFSFLNTSDMEDSEGSEEEALQDERRASRARRGSRAASAGEVGADDTGTCSGSEGSADPMSTGNEFLDKALVLHLHNCNHLLLNLGTFGPLRCREMFALDRLLREAQVLEIVCQLMEERSEAAGSAAGVVQFSTRKEGVLPLWDHCVELPNIYTCPVERFLQVLSAQYAAPISERHPGLADAVCVKLVEDVLNRRLPRRPGGTQGEQVTIFQYWSHFEALGALVLDTYVMELAEEVLLAQNLNSDDQDVVLRALKRVPEGRLKKEGLKALSLLLVEGNSKVVSAVSAQLRSLAENPRFRQRALVCFLGQLEDEEVQTRVAGCVALGCLKAKESIEQLVYLCQTDKEPVREAAKQSLMLCGEDGKSAHRRLEETLDSLPRIFAPASMASTAF
The following text describes a protein:
Function:
Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS29-VPS26-VPS35 subcomplex may be involved in recycling of specific cargos from endosome to the plasma membrane.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Prevacuolar compartment membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MLLNRVIVIGIESSESWLVLNYLRGAFKPACNISITFTDGKNRKQVPVKKDNGQMVMNPLFHSQETIAGNVCIEPYQGKKVEHNGVKVELLGQIEMYFDRGNFYDFTSLVRELDVPGEIYENKAYPFEFPTVEMPYETYNGVNVRLRYVLKVTVTRGYAGSIVEYQDFVVRNYSPLPPINNSIKMEVGIEDCLHIEFEYNKSKYHLKDVILGKVYFLLVRIKIKNMDLEIRRRESTGAGANTHVETETLAKFELMDGAPVRGESIPVRLFLTPYDLTPTHKNINNKFSVKYYLNLVLVDEEDRRYFKQQEITLYRLKDESS
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLVTLIFQLCALQTYASTDAPLGSSLALLWCIGNCILYVGVLTFCIIERRWLFADARTGTGINFIPFIKTSITIVTHLVVLLEALIARGVYRALDVRVASVDGALGHLTDRAASSLARARTHFRNKLLLFCAFCCAIELGILALVYSDPVQLALWCLTVPSLVIIRLKHLHHAYHIDRLTARFDILREQLESLVTDGVSPGRPKPTEATAVPPKAQTSLTRWKMNGPSRPAVIVDSWTGLSTMKSPVSIGATSQVDRVPLRRMFVVKGTYLTLWHASKDLNGCCVYSQLANLLQNFIQCTCDLYSLYALLYLNQLDDIFAYILSIVATFTALGVVLAACENCKNQVGQMGQLLYKRLHGDEADLLAKMLENFSLLLQHTPMSFSLGGFFDMDFVLLKEIAAAITTYMVIFIQFMPKEDTPTDATTASNSTLANSTATATPE
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MNKRITSSQMSWRALLSHNLREIRITFCQSNKSSEGLRNFVVNNYTDLKRLNPKLPLLIREGHGIEPTIYARYDWGEEEKTVVTNLSEQEVEEKLKEICLLGDNQQREPKRFDEFDIVSAYDKNVVPLRPYF
The following text describes a protein:
Function:
Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MNRAKVLSSYLGLLRTEKKVFQNDKRALEHVINLTRVQFRDNKNETDNTKINEMIDHANAVSHFLVKDLIQGVRKDEKTIQLKFDENTKSYQQYEFVNDQPPQRKKRGKIQIDDEQPTTCCGGGCGKPMPSNNSEKSTCS
The following text describes a protein:
Function:
Thought to be a Golgi-localized beta-glycan synthase that polymerize the backbones of noncellulosic polysaccharides (hemicelluloses) of plant cell wall.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MASSPPKKTLNSQSSSLSRPPQAVKFGRRTSSGRIVSLSRDDDMDVSGDYSGQNDYINYTVLMPPTPDNQPAGSSGSTSESKGDANRGGGGGDGPKMGNKLERRLSVMKSNNKSMLLRSQTGDFDHNRWLFESKGKYGIGNAFWSEEDDTYDGGVSKSDFLDKPWKPLTRKVQIPAKILSPYRLLIVIRLVIVFFFLWWRITNPNEDAMWLWGLSIVCEIWFAFSWILDILPKLNPINRATDLAALHDKFEQPSPSNPTGRSDLPGVDVFVSTADPEKEPPLVTANTLLSILAVDYPIEKLSAYISDDGGAILTFEAMAEAVRFAEYWVPFCRKHDIEPRNPDSYFSIKKDPTKNKKRQDFVKDRRWIKREYDEFKVRINGLPEQIKKRAEQFNMREELKEKRIAREKNGGVLPPDGVEVVKATWMADGTHWPGTWFEPKPDHSKGDHAGILQIMSKVPDLEPVMGGPNEGALDFTGIDIRVPMFAYVSREKRPGFDHNKKAGAMNGMVRASAILSNGAFILNLDCDHYIYNSKAIKEGMCFMMDRGGDRICYIQFPQRFEGIDPSDRYANHNTVFFDGNMRALDGLQGPVYVGTGCMFRRYALYGFNPPRANEYSGVFGQEKAPAMHVRTQSQASQTSQASDLESDTQPLNDDPDLGLPKKFGNSTMFTDTIPVAEYQGRPLADHMSVKNGRPPGALLLPRPPLDAPTVAEAIAVISCWYEDNTEWGDRIGWIYGSVTEDVVTGYRMHNRGWRSVYCITKRDAFRGTAPINLTDRLHQVLRWATGSVEIFFSKNNAMFATRRLKFLQRVAYLNVGIYPFTSIFLVVYCFLPALCLFSGKFIVQSLDIHFLSYLLCITVTLTLISLLEVKWSGIGLEEWWRNEQFWLIGGTSAHLAAVVQGLLKVIAGIEISFTLTSKASGEDEDDIFADLYIVKWTGLFIMPLTIIIVNLVAIVIGASRTIYSVIPQWGKLMGGIFFSLWVLTHMYPFAKGLMGRRGKVPTIVYVWSGLVSITVSLLWITISPPDDVSGSGGISV
The following text describes a protein:
Function:
Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDNLKSKNKGNGGGDHDNYGNDNDKFNVLSDKFDALLALKNPQLVSLPFPKIKPLDNIHKARILLPPSDENYVQIKKPPTQPINNINITSLNNNNSSTTTNTSPPIESTPTTTTTTTTTTTTSTTSTNSIASIVETTTTTTTIRKKNTNEDHKILKNISNKFTDGPLSLLKRALESKSKIKVMIRGTNCIRGYCRGYIIAFDKHMNIILRDVEEEYDLLKSLPSTRNQNQPIQPKIKRYYGQLFIKGDTVVSVILID
The following text describes a protein:
Function:
Receptor for the LURY-1-1 and LURY-1-2 peptides which control food-related processes including feeding, lifespan, egg-laying and roaming behavior. Receptor for flp-7 which stimulates serotonin-induced fat loss. Serotonin induces secretion of flp-7 from neurons and binding to npr-22 which leads to induction of the atgp-1 lipase and subsequent fat loss. Acts in vitro as a receptor for the flp-7 FMRFamide-like neuropeptides TPMQRSSMVRF-amide, SPMQRSSMVRF-amide, SPMERSAMVRF-amide and SPMDRSKMVRF-amide. Also acts in vitro as a receptor for a number of other FMRFamide-like neuropeptides including the flp-1 neuropeptide PNFMRY-amide, the flp-9 neuropeptide KPSFVRF-amide, the flp-11 neuropeptides AMRNALVRF-amide, ASGGMRNALVRF-amide and NGAPQPFVRF-amide, the flp-13 neuropeptides AADGAPLIRF-amide, ASPSAPLIRF-amide, SPSAVPLIRF-amide, SAAAPLIRF-amide and ASSAPLIRF-amide, and the flp-22 neuropeptide SPSAKWMRF-amide. The SPMERSAMVRF-amide neuropeptide from flp-7 acts as the strongest in vitro activator of npr-22.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDEGGGIGSSLLSRITTTASEIMMRNEPTTTENPAVQEMNHIYHLTPSMKMLCILFYSILCVCCVYGNVLVILVIVYFKRLRTATNILILNLAVADLLISVFCIPFSYWQVLIYDDQRWLFGSMMCSLLAFLQAMAVFLSAWTLVVISFDRWMAIMFLLTPNIRITRRRALYLVAATWIFSILMALPLLFTTRFFEDQDGLPNCGENWTYFGDSGEQVRKVYSSMVLILQYVVPQAVLIITYTHIGIKMWNSRVPGMQNGATKKMIVDRHESVKKLVPMVILISALFALCWLPLLILINVIPEFYPDINSWGYILYLWWFAHGLAMSHSMVNPIIYFIRNARFREGFCFFSSKLLPCISFKELRLLTDNTSRSFRNRSRFSGVINPTSSDEKPATSLTRYSRSGVLDRQTCRSARFFEARPLVVVRNNSANSLA
The following text describes a protein:
Function:
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Sequence:
MSSSSLKTPFLVEQRHMIIVPSYSAWFNMSTIHEIEKKSNPEFFGGNSTLKTPTAYKDIRDFMINTYRLDPSEYLTVTACRRNLLGDACSIIRVHAFLEQWGLINYQVDPETRPNFKAPPFNGKYNAVNNTPKMTQEVLAQHEAKNSDEPIPKQITLQTKVYNSVTNQMEPKDAVDETEQDKAEAPFVHVQCFTCGVDCSHAYYHNLKMKKHHLCRACYEQGRFPSSFTSADFLRMDTAYFQQYRDDEWTNQETLLLLEAIEMYDSDWNQISMHVGTRSREQCLVHFLQLPIEDPYRISVENQVSTLKNHSLPFSEADNPVLSILTYLASVLIESKQKAHNNNETTKNDGEQSAEPQASETSHLEKAATVALKVAARKAGVLADYEKRQMQRLVYLLVQTQVEKVNLKMEILDQLEEISSFEFFELDRQRKQLLIEQLSTKKMLLDVGKQVKEALSLGNDQGLAIIDKLLLSEGKEIPLTFESPPSVNVRPISEEFPSEYRSIAL
The following text describes a protein:
Function:
Mediates the adhesion of neurons to neurons and neurons to glia. It is involved in neuronal migration, neurite fasciculation and outgrowth.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MALPMVGLLLLLLLGGPGAAITIPPEYGAHDFLQPPELTEEPPEQLVVFPSDDIVLKCVATGNPPVQYRWSREDQPFVPEEHGGVSVVPGSGTLVINATLAARLQGRFRCFATNALGTAVSPEANVIAENTPQWPKEKVTPVEVEEGDPVVLPCDPPESAVPPKIYWLNSDIVHIAQDERVSMGQDGNLYFSNAMVGDSHPDYICHAHFLGPRTIIQKEPLDLRVAPSNAVRSRRPRLLLPRDPQTTTIALRGGSVVLECIAEGLPTPWVRWRRLNGPLLPGGVGNFNKTLRLWGVTESDDGEYECVAENGRGTARGTHSVTVEAAPYWVRRPQSGVFGPGETARLDCEVGGKPRPQIQWSINGVPIEAAGAERRWLRGGALVLPELRPNDSAVLQCEARNRHGPLLANAFLHVVELPLRMLTADEQRYEVVENQTVFLHCRTFGAPAPNVEWLTPTLEPALQDDRSFVFTNGSLRVSAVRGGDGGVYTCMAQNAHSNGSLTALLEVRAPTRISAPPRSATAKKGETVTFHCGATFDPAVTPGELRWLRGGQPLPDDPRYSVAAEMTVSNVDYGDEGTIQCRASTPLDSAEAEAQLRVVGRPPSRDLQVMEVDEHRVRLSWTPGDDHNSPIEKFVVEEEEEREDLQRGFGAADVPGQPWTPPLPLSPYGRFPFRVVAVNAYGRGEHHAPSAPIETPPAAPERNPGGVHGEGNETGNLVITWEPLPPQAWNAPWARYRVQWRPLEEPGGGGPSGGFPWAESTVDAPPVVVGGLPPFSPFQIRVQAVNGAGKGPEATPGVGHSGEDLPLVYPENVGVELLNSSTVRVRWTLGGGPKELRGRLRGFRVLYWRLGWVGERSRRQAPPDPPQIPQSPAEDPPPFPPVALTVGGDARGALLGGLRPWSRYQLRVLVFNGRGDGPPSEPIAFETPEGVPGPPEELRVERLDDTALSVVERRTFKRSITGYVLRYQQVEPGSALPGGSVLRDPQCDLRGLNARSRYRLALPSTPRERPALQTVGSTKPEPPSPLWSRFGVGGRGGFHGAAVEFGAAQEDDVEFEVQFMNKSTDEPWRTSGRANSSLRRYRLEGLRPGTAYRVQFVGRNRSGENVAFWESEVQTNGTVVPQPGGGVCTKGWFIGFVSSVVLLLLILLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESEAEKGSASGSGAGSGVGSPGRGPCAAGSEDSLAGYGGSGDVQFNEDGSFIGQYRGPGAGPGSSGPASPCAGPPLD
The following text describes a protein:
Function:
Possesses activity on acetaldehyde and glycolaldehyde in vitro.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MASRRVSSLLSRSFMSSSRSIFSLRGMNRGAQRYSNLAAAVENTITPPVKVEHTQLLIGGRFVDAVSGKTFPTLDPRNGEVIAQVSEGDAEDVNRAVAAARKAFDEGPWPKMTAYERSKILFRFADLIEKHNDEIAALETWDNGKPYEQSAQIEVPMLARVFRYYAGWADKIHGMTMPGDGPHHVQTLHEPIGVAGQIIPWNFPLLMLSWKLGPALACGNTVVLKTAEQTPLSALLVGKLLHEAGLPDGVVNIVSGFGATAGAAIASHMDVDKVAFTGSTDVGKIILELASKSNLKAVTLELGGKSPFIVCEDADVDQAVELAHFALFFNQGQCCCAGSRTFVHERVYDEFVEKAKARALKRNVGDPFKSGIEQGPQVDSEQFNKILKYIKHGVEAGATLQAGGDRLGSKGYYIQPTVFSDVKDDMLIATDEIFGPVQTILKFKDLDEVIARANNSRYGLAAGVFTQNLDTAHRLMRALRVGTVWINCFDVLDASIPFGGYKMSGIGREKGIYSLNNYLQVKAVVTSLKNPAWL
The following text describes a protein:
Function:
May act as a component of the auxin efflux carrier.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MITGKDIYDVFAAISLYTWLAMILAYGSVRWWKIFTPDQCSGINRFVAVFAVPLLSFHLISSNDPYAMNYKFILADSLQKVVILVALFLWRAFSKRNNLEWMITLFSLSTLPNTLVMGIPLLKAMYGDFSGTLMVQIVVLQSVMWYTLILFMYEYRDAKLWVSEHFPETAASITSFRVDSDVVSLSGREPLQTDSEIGDDGKLHVVVKRSNALSFNRSHRLNSLNSMTSRVSNLTGVEFYSVQSSLETTTRASSFNQTDFYAMFSASKAPSSKHGYTNSFQGGFGDNEEALKMSTTNKKRRGRSMSCEVFNDGMVSSYPPANPMFERSTSGVPKKKDSGGGDGEAVRNKDLHMFVWNSSASPDPEGNLRHAVNRAASTDFGVIDPSKAAALQQHETAASKGMHDLIANMSPGRKTSADRELEIEEGSKFPASESPYGSFRKKVDMEDGGVAKNHQMPRASIMIRLILIMIWRKLIRNPNTYASLLGLAWSLISYKWHIKMPTIVSGSISILSDAGFGMAMFSLGLFMALQPKIIACGKSVATFAMAIRFLAGPAVIAGTSIAVGLRGVLLHVAIVQAALPQGIVPFVFAKEYNVHADVLSTAVIFGMLLNVAVTIIYYILLGL
The following text describes a protein:
Function:
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MATTILDEETSKKVIRQVEFYFSDSNLPRDNFLRKTIEENEDGLVSLALICSFSRMRGHLGIGDVKADAVSEETVKAVADTLRTSDFLKISEDGKKVGRRSELNNPEEMIEQVDSRTIAASPLPYDVKLEDVESFFAQFAKVNSVRLPRLVSHKNLFCGTALVEYSSEEDAEKVMSQTLAYAGADLELKPKKDFIAEREKLEQAYEKSGRGNGNSKVPEEASYPKGLIVAFTLKSKSQGDESKQNGSNEHVIEAEAKTNGSADSDKNGAAEIVEETKAEATPEGTPDEEGKETEGDEKSSEGADKKAVQKTAQEGKNAVESYKDDMDVVIREDLKALFQKFGTVKYIDFKMGETSGYIRFEDSEASQKARAAAVLTEDGGLLVKNFIATLEPITGDQEKEYWSQIQGSQRKFQDNRGGHRGRGGRFNNRGGGRHGRSRDRDSPAGRHNKVQKVSA
The following text describes a protein:
Function:
Metalloprotease (By similarity). As part of the innate immune response to molting and injury to the adult epidermis, positively regulates the activity of the transcription factor sta-2 to promote the expression of epidermal antimicrobial peptides such as nlp-29. Through regulating the expression of epidermal antimicrobial peptides such as nlp-29, modulates sleep duration and locomotion quiescence during the sleep-like state called lethargus which occurs during molting between larval and adult stages. This may occur through the sleep-active RIS neuron.
Subcellular Localization:
Secreted.
Domain:
The TSP type-1 domain may be involved in modulating sleep behaviors.
Sequence:
MPSPSYNRHIIIASCFCCLLIFSSAARVPKASKKHLARVKQLLNDEAERHNTLIQSDSVTVFDDIQRNPNTGVHHDELAVNNADEYFQGDVDLSEQQVKIIEDQFTQGKREKRKIGRNPLYKKWDTRGPISFDYAESIPFQTRQKIRSAMLLWQQHTCLRFEEGGPNVDRLEFFDGGGCSSFVGRVGGTQGISISTPGCDVVGIISHEIGHALGIFHEQARPDQERHIAINYNNIPLSRWNNFQAVGENHAETYNLPYDTGSVMHYGPYGFASDPYTPTIRTLERVQQSTIGQRAGPSFLDYQAINMAYGCTESCADLPCLRNGYTHPNNCSMCACPEGLSGRYCEQVYPSNAQCGGVIFATKEVKYITSPNYPDKFPIDTECNWIIAAPIEGRVFMEFEGDFDFLCEDTCDKAYVEVKYHSDKRLTGARYCCSLLPKNRFISFKNEMIIIMRGYRSSGAGFKAKFWSNLGEPEGVSTPLPPTTAPLPEISETTQKPEPTTVQSTTTYTTAIPRRTAKKQFFTRKPITIPLTPLTSSSTTTESTTVSSTTQSTTWLPTEPSFATGETEITTASPTITLFPSLSTILPPINSLAGVLPSTQAPDIINSVLECGCGAWSEWQGECSQQCGGCGHRLRKRECKKEACRKEEKRPCNFSACPDGTNFLINNAEFHILWRGCCVGLFRSGDQCSALETESNPFFKIINSLLNIQDAKNNDTLIAKRMMRGEH
The following text describes a protein:
Function:
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Sequence:
MENSNVENVASSLVREYLSRKGLKGTLQTMDSEMPRSEGSISNRLQLAKELHLEYLMKKNKECSPPLRAMLEVMTKYFLQKIDVGREDKRQSSGSRPSSRMSSERPSSRSASHSKAPSDDSGFHSNQSNHHAKRASKGSALGLDIHNVEDEEGMGSTAISDVSKAGVHSTVEESVLQLKKETSSKMAATDARDTAEATQTKKSRPNSSRGLRSGMMAGPIMSSQDNRSSRRGRAPSNRPNLAINLGTENKLDFTKDPTNVDSPISKYSESKVSSSTLSSSLTRKDSSSDSNLGSDKSLYVAKDPAKKTVSEEENDYFDSKRPTSGSKLVKSTSLDDKVVSPNVGTRTKAHDKRRKSAEPESLAAKLDGKISPTPNNLSQTNRSSSNPSEILTDISQDTLTEQLAARREARAKTRPKTSENGGSSRMDKLKERLKNLEDSFDDNGSNNSKSRKSNSSSSNSNTKKFGDLEMGDVDDLEDDLGDLALSAPAPSIKPLADAQPITAETAAELKTLLFGSASEQFNAEWRNQSLSFCDTEGLRFGIVQNKGGPCGALAAIQACMLKRLLFGEARDKTANAHRLLSPDSRLRSECLALGLADLLWRAGRKKLAVVAMPSGRKQFQGGARYRQDNLTETLMLNTVDSQGDLEAFIKQNISLFETNQYATILVLYSAILSRSIDHVISDMDEPTTKLIGAHGYCTQEMVNLFLTGKAVSNVFNDTVELDSGGGETMILRGVGSRSEIGLLSLFEHYGSCQVGTYMKTPRYPIWVVCSESHFSVLFCIRKELMNDWKYERRFDLYYYDGLARQDEQIRLTVDNLHPYQPPGEGELIPPLEHCIRTKWNDATVDWNGTDPIL