lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.
Subcellular Localization:
Nucleus.
Sequence:
MEQEAEGLSQWQVAQQQLEEDADKLMSILDMSPFPGSSGVHTSWNHGLPVIQHVPQCTESPVSRPYHCQYENCGKAYTKHSHLVSHQRKHTGERPYKCTWEGCTWSFFRSDELGRHMRIHTRYRPYRCDQCGRQFMRSDHLRQHHRTHLQVLGSSDAQASNGQIPGPPAPGL
The following text describes a protein:
Function:
May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of RIGI, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of RIGI with MAVS/IPS1, an important step in signal propagation. May also regulate the SLC18A3 and SLC5A7 cholinergic transporters.
Subcellular Localization:
Cytoplasm. Golgi apparatus.
Sequence:
MSGEEMNLRGTTGISEVFVSEKRWFFSFGSSTGTRCVCLLLELTFITAAMVQKYQSPIRVYKHPFELIMAAYERRFPTCPLIPMFVASDTVSEYKSEDEAIHVIERRCKLDIDAPRLLKKIAGVDYVYFVQKNSLNRRERTLHIEAYNETFSNRVIINEHCSYTVHPDNEDWTCFEQSASLDIKSFFGFESTVEKIAMKQYTSNIKKGKEIIEYYLKQLEEEGITFVPRWTPPVACKLESSTSHTRRPVSPAVNVPDSATKEGLNNKEILNISSSPSELTAGTPDDKLDADYIKRYLGDLTPMQESCLIRLRQWLQETHKGKIPKDEHILRFLRARDFNIDKAREILCQSLTWRKQHQVDYILDTWNPPQVLQDYYAGGWHHHDKDGRPLYVLRLGQMDTKGLVRALGEEALLRYVLSINEEGLRRCEENTKVFGRPISSWTCLVDLEGLNMRHLWRPGVKALLRIIEVVEANYPETLGRLLILRAPRVFPVLWTLVSPFIDDNTRKKFLIYAGNDYQGPGGLLDYIDKEIIPDFLGGECMCEVPEGGLVPKSLYRTAEELENEDIKLWTETIYQSASVFKGAPHEVLIQIVDASSVITWDFDVCKGDIVFNIFHSKRAPQPPKKDSLGAHSITSPGGNNVQLIDKVWQLGCDYSMVESPLICKEGESVQGSHVTRWPGFYILQWKFHSMPACAATNLPRVDDVLASLQVSSHKCKVMYYTEVIGSEDFRGSMTSLESSHSGFSQLSAATTSSSQSHSSSMISR
The following text describes a protein:
Function:
May play a role as a nucleotide-sugar transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Mitochondrion.
Sequence:
MMLHISVLKGKDDVNLQKGVFIGSPKRYPLSSRWADKLSAVGCNGTEEHNFQHPFLQAVGMFLGEFSCLAVFHLLRCRDRRRTEPVMAPSQPFNPLLFLPPALCDMTGTSLMYVALNMTSASSFQMLRGAVIIFTGLLSVAFLGRKLALSQWLGILITILGLVLVGLADLLSGNGQSHGLSQVITGDLLIIMAQVIVAIQMVLEEKFVYKHDVHPLQAVGTEGFFGFIILSLLLVPMYFIPAGEFGSEPRHVLEDALDAFCQIGHRPLIVLALAGNIQSIAFFNFAGISVTKEISATTRMVLDSLRTVVVWAVSLALGWEVFHGLQILGFFVLLAGAALYNGLHKPLLDRLPCRKDGAPETDREGLLAADGVASINGDS
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MRPFLSVSTALAWALSWSLVAVSFAKPVGDSKTLVLLDDLANRSEYSIFLDSLTARGHRLFVHTVAQISTTVPLLVYGDLAFSHVVILASKVSTFGGTVGVGGLIDYVNAGGNVLLAASSELSEVVRDFAYEFSVDFDESGTSVFDHFNSIHDSPSQIISSSFTNKTNFILSESTRQGPPVVFQGVGHKVTGKNILTFPILTASHSAYSYDSKDTDPLLGGPLLGETISLASAFQARNNARVVFVGSTSLFSNKSICGNAAFSADISKWVFQEKSVVQITNTKHHRVNETDQHGIYRIKDEMIYSATIKVWSGDAWEPFVANDIQFEAVMLDPYIRKTMNESDGVYVARFTLPDQYGVFSFKLNYQRHGLSYISASETVQVRPFRHNQFPRFLVVAYPYYANIFSLMVAFFLFSAVFLFNKEVRPKTKTL
The following text describes a protein:
Function:
DsRNA-specific nuclease that cleaves eukaryotic pre-ribosomal RNA at the U3 snoRNP-dependent A0 site in the 5'-external transcribed spacer (ETS) and in the 3'-ETS. In vitro, cleaves synthetic 5'-ETS RNA A0 site in the absence of snoRNA or other factors. Has an essential growth function in addition to pre-rRNA processing.
Miscellaneous:
MISCELLANEOUS: Present with 4970 molecules/cell in log phase SD medium.
Sequence:
MGSKVAGKKKTQNDNKLDNENGSQQRENINTKTLLKGNLKISNYKYLEVIQLEHAVTKLVESYNKIIELSPNLVAYNEAVNNQDRVPVQILPSLSRYQLKLAAELKTLHDLKKDAILTEITDYENEFDTEQKQPILQEISKADMEKLEKLEQVKREKREKIDVNVYENLNEKEDEEEDEGEDSYDPTKAGDIVKATKWPPKLPEIQDLAIRARVFIHKSTIKDKVYLSGSEMINAHNERLEFLGDSILNSVMTLIIYNKFPDYSEGQLSTLRMNLVSNEQIKQWSIMYNFHEKLKTNFDLKDENSNFQNGKLKLYADVFEAYIGGLMEDDPRNNLPKIRKWLRKLAKPVIEEATRNQVALEKTDKLDMNAKRQLYSLIGYASLRLHYVTVKKPTAVDPNSIVECRVGDGTVLGTGVGRNIKIAGIRAAENALRDKKMLDFYAKQRAAIPRSESVLKDPSQKNKKRKFSDTS
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSSTAHSPQKIKLCEHILLQHFGPIAARVGALLLKRGRLTIREISRFLNQQPTRTNRGPIDPFSNHSATNSKSTLVSAPIAGASSSSSTSDPNAPVPVPKLLIEQTVMTLIQHGCAWHSSTDPDVADPNQEFFEININEVLLRLRFGRYIGIAEDELGQTAARIVKLVLQHGKLQANDIIDRVATEMDAQHKPTSLTADAQPNRGDPPNGTANGSNNKKRKADSATELSALQSQVARQLTLLLYRTYLRPSSVHQHVSPRDKEIKYEAKKRRELRGIPTPKDLQKIKEQVRAQIAEERDADWDITATTVTLGPDGLAADHCGSRRGLLRKQQSAIAVASSASKSKRAKTSSKSKDKTKDKNGVNGIDGVHGSACRDTFDPADDFDIDPTVWLRVHFDRFDVHLRDEVMIDAVREKYNNTAAEVFRHLIQAGDASTNKSVRDVRSAPISITTLCHKLPSDLSLQKGFDRRSFGKDRASLPSKQEFLAEYSAIFSHSEDVSGRSKSLRLMAPASDSTTKTAGGSKVASTLTIEFGNLAEGMRKDLLRNVVEEKFGTAAIRIMNILREKGKLEEKHISKLALVSISETRDLCSRLFHASLLGLQEVPKTKDRDPAKTFFLWFVDEAKCRAWLLDHLYQSLARLGQRRNEEMRKQTPLLRKVERSDVKMDTLGLLTEWERHSWQRLQGVLQTLTVAEMRTEMDVFVMRDLAAGTYVSQE
The following text describes a protein:
Function:
Could be involved in the export and assembly of the putative YbgD fimbrial subunit across the outer membrane.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MNIYRLSFVSCLVMAMPCAMAVEFNLNVLDKSMRDRIDISLLKEKGVIAPGEYFVSVAVNNNKISNGQKINWQKKGDKTIPCINDSLVDKFGLKPDIRQSLPQIDRCIDFSSRPEMLFNFDQANQQLNISIPQAWLAWHSENWAPPSTWKEGVAGVLMDYNLFASSYRPQDGSSSTNLNAYGTAGINAGAWRLRSDYQLNKTDSEDNHDQSGGISRTYLFRPLPQLGSKLTLGETDFSSNIFDGFSYTGAALASDDRMLPWELRGYAPQISGIAQTNATVTISQSGRVIYQKKVPPGPFIIDDLNQSVQGTLDVKVTEEDGRVNNFQVSAASTPFLTRQGQVRYKLAAGQPRPSMSHQTENETFFSNEVSWGMLSNTSLYGGLLISDDDYHSAAMGIGQNMLWLGALSFDVTWASSHFDTQQDERGLSYRFNYSKQVDATNSTISLAAYRFSDRHFHSYANYLDHKYNDSDAQDEKQTISLSVGQPITPLNLNLYANLLHQTWWNADASTTANITAGFNVDIGDWRDISISTSFNTTHYEDKDRDNQIYLSISLPFGNGGRVGYDMQNSSHSTIHRMSWNDTLDERNSWGMSAGLQSDRPDNGAQVSGNYQHLSSAGEWDISGTYAASDYSSVSSSWSGSFTATQYGAAFHRRSSTNEPRLMVSTDGVADIPVQGNLDYTNHFGIAVVPLISSYQPSTVAVNMNDLPDGVTVAENVIKETWIEGAIGYKSLASRSGKDVNVIIRNASGQFPPLGADIRQDDSGISVGMVGEEGHAWLSGVAENQLFTVVWGEQSCIIHLPERLEDTTKRLILPCH
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDLANHGLILLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQTSECVRLKPTDIQPDIFSYLLHLMYTGKMAPQLIDPVRLEQGIKFLHAYPLIQEASLASQGAFSHPDQVFPLASSLYGIQIADHQLRQATKIASAPEKLGRDPRPQTSRISQEQVPEASQLSQLTSNLAQVNRTNMTPSDPLQTSLSPELVSTPVPPPPPGEETNLEASSSDEQPASLTIAHVKPSIMKRNGSFPKYYACHLCGRRFTLRSSLREHLQIHTGVPFTSSQQGESRVPLTLCSNAADLGKDAMEVPEAGMISDSELQHISDSPIIDGQQQSETPPPSDIADIDNLEQADQEREVKRRKYECTICGRKFIQKSHWREHMYIHTGKPFKCSTCDKSFCRANQAARHVCLNQSIDTYTMVDKQTLELCTFEEGSQMDNMLVQTNKPYKCNLCDKTFSTPNEVVKHSCQNQNSDVFALDEGRSILLGSGDSEVTEPDHPVLASIKKEQETVLLD
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSRIPTLGTENQYGEKVDKCIVDLGIKTGSGVLVGGLFSLLFKRRTWPITLGAGIGIGMSYTTCQNRFKNFINNKLESQNSAASSEEVTTTVDPAPDTPTQSEQSDSGSA
The following text describes a protein:
Function:
Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MLGLRLPVCRRAVMASPRACWRLWHSSTAAAAGMQDLSAVLQRNLALRNQSLYNQSSDTIRCSMFDSDGALIGGAAADIRREELIQKHGLLPRDLRKIEMARRHDLVPIVLVRDRCIMVSLLTIRALVKSDTVLLFDPMGIGMDSVAHTRFVADLQTRLKNQGAPGLGKDPLPYEFRALESIFITALANLTAELRVHLAVTKGALHDLEYGIDKDKLKFLLVQNKKLSVFHKKSLLMREMMDDLMDQDDVLSEMYLSEKMRGKPRDVADHSELEMVLETYYTQVNEIVQSIEGAIANVRTTEEIINIILDSNRNELMLLGLRFAIGLLSLGSVMFVAALYGMNLENFIEEGNVGFALVTATGLVLMVCLFRYSIKRLHKLQKMTLLGGQGRHS
The following text describes a protein:
Function:
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
Sequence:
MARSTRNVYLLLFIAIFIIMSLILYSSIDSPSSMRRADKNAEVLRLQQKMSSLEENLRRNGEEMDRLRKELRESERLRKELEKKEIGEIFAQVPEPRGGGNKAEVVRRFLSKTTKPARDVCPMRKEMSVPNSEIQMFDMYNLIDFANTDGGVWKQGWEVKYDAEAVKTEPQLEVIVVPHSHCDPGWLRTFEEYFDAQTKLILDGMATHLPQQDQMSFIYAEVSFFELWWRGLDEPTREKVKGLLSSGRLELVTGGWVMADEANTHYNAIIAELMEGHEWIKNHLPKEALPRVHWSIDPFGISPTVPYIMSAANITRAAIQRVHYSVKKELAKQRNLEFVWRQMWDSSKATDVRTHMFPFYSYDIPHTCGPDPKVCCQFDFRRLSGGGFAGCPWGIAPQLINEDNVATRAALIYDQYRKKAQLYKTNAVLIPLGDDFRYDTTFEWKQQYENFQKLFAYMNGQKEWNVKARFGTLSDYFSVLEKHTVEQKIDLPVLSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAEIVFSLSHMSGGDSGPASEESFERLVRARRALALFQHHDGVTGTGKDHVVKDYGQKMLDALRDCEEVITVATEVLLQKKGSAAGQLQLDESRSAHDALPERRAAEVGSSLILFNALSTVRHEVACVRVADAKARLCFDTSIAPLSLQTYSVVSEASSTDDGERATVAGTARVESNDFKSASLPSGNVVLKNDRITAEFDAGTGMLESVTPVGASTATKTHMKFVKYGARGHKRMNNGGGDDLSGAYLFLPDGDAKDVPSGDSHYVVVQGPLVSRVYVQGPQEFRLLTTYSLDAGAPYVEITNEIDITERMQNVEVAMKIESSVDSADSIYTDLNGMQMIRRRRQLDRLPLQAHYYPMPGAAFVESAEERLSLMGAQALGVASLKPGELEVMLERRLLQDDGRGLQQGVMDNLRTVSHFRLMVERMGGERSAEDERMGFLSLPATSASRSLHYPWVKILSEDSDLSPSFIGLQAPLPCDTHIVTLRTIAEPTKYGSARPTTAPSSSAALVLYRPLVDCRSTTPAADECADSKGEDSFSVLFGAGLKSASTATLTMLYESKGTTERLAVEPQQLMAYKLRF
The following text describes a protein:
Function:
Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.
Sequence:
MSSLDYPEDFENNNPFAEPVISDQVNGVHSQTENNETQLPEGEPTAPQSGEPSPDPNSESILTEDELRKLIPERFTTKYSLSIQLVEIEKNKPGNPILKMNVKVKGLPRYRQSIYKDVRRTFNEVVKFNRYLIVSNLEVFVPVIPSAITSYPTGGEDERKKLFVEWQEWLDRITSNPILIRDEEFVYFVENDFGYSVINTNRKTSVASGIMRKTLKQFAVPYDPYEELANFRPIIKEAYLTFQKLHKLLDRNSKTEKQLSIHIYDMANKLNQLSEFETTHPGMKNMWEKLGKITQKQSDFTLVDSINEMATLGDGTQILIDDFYEIKEALTNRHLIMRELIQAETQTNAKHVQANKIKNKSSLDPIKVDEALRSLEYASKVQESLHLQVKRISGEMMFERKEVIDFTEKKIQRLMKGYTLHKVEHHRKILKHFENIRLDVRSVDDKGGLSRLNRDNLTNLKHNLTQSQSSQGDSWSSRTFRSLEKEEEENENKKSDVNGFESATVDARNAASLLGVATF
The following text describes a protein:
Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.
Sequence:
MVTSFLEYLTTNDRNSCGYCKNEQGERTPDSSNSYTLTGGAWAHNMNAKDYGRLLDMGWRRSGRYLYKPNNRLTCCPQFTIRLDVTKFKMSRSQKRAMRQMNEFLATGKRPVCGIKEEDSVEKNQKKSSLTSAETTSTSHQEPPSKKMKDSDRPVLTKKEILNKRFLEKCQQRNLDPEEVRAERKAKDAARQRTIQSYIDEARPDWKHKLEIKIIPVDSREFDERSNESFDLYKRYQTTIHNDHHCRFAGFRKFLCDSPLSIEKRDGVELGSFHMWFLLDEKIIAVSVLDVLPQCVSAKYMFYDPDYSFLSLGTYTALREIDVTKRFQQICPSLRYYYMGYYIHSCPKMRYKAKFRPSDLLCEKSKTWLTFDACKELLDKSTNSNGFTEFRPEEPQQIPLAVDDILVYSKREILTFAQALIRFPEIADNNEFLQKVRELTILVGPDLSEAVYFFSEFNS
The following text describes a protein:
Function:
Absolutely required for transposition of IS1.
Sequence:
MASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTILRHLKNSGRSR
The following text describes a protein:
Function:
Forms a voltage-independent potassium channel activated by intracellular calcium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MERPNSRLHCHPETHTYKCTVQPYFPLHTHATTVYGNVTKHRPSLGTLQAGDTLHARRFLSDKRRSYRNRSLGPTIASAPSVEQEDYRTPRPSFDSNGYVGKSFDFSSAQHGLTASESNALVKVSADFLRLNGSRQQFKNLLSARKKLGSLPPAYTRIDYSRESLDSHSARGIPNHHGPVITVEDTGSQLRINNIKPSVNQHLLESSCSFEKTMVTQCESNGSVTSHNTSSAFQRNNSRYGVPIDSTAVKQVYRVRSERLTNRVRITDRSLYLALFGVILMLVESEITAEKFYGVSKTHWISQSLRVGVTCSTIALLYHIILYHLNDIVLELVDCGADDWRVVVTTERVIQFCIEFICCGICPLPGSGEMKWTFIEPSLHKDGPSEERTVQTRNVDVPVDVILSCFMLCRSYLFARFMVLHSKQFQDASTRTLAALNRIQVNFSFVIKTSLDQQPVLFLTTFTFIFWIIMSWMFVQCERYGFSGKNPQSILYSNSLWFIAITFMLNGYGDIVPQTNAGRFIAIFVGVVGAVISSILIAVISRNILLSQGQRNVNNFMYDSKLAREHKEAAARVLQHTWHIHKCLQGSDGGNRRLRTYQRKFLKAIHKFRSVKSEMREFSENNSQNNPQMTRLVTDMHTSMQRLLNVQDEMRMQIEVLQQSVRNHYMHSTPNVPHLQGLTSSPVPSDRYDNRF
The following text describes a protein:
Function:
Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
Subcellular Localization:
Nucleus.
Sequence:
MSNNSGANGYNDSNRAFLQAFMARSTMTFEEARSVLAAIFSVHEGQPVSPDDVSQEDLDSYINAANAAISPFDLEIRSTLRQLQIDHHINETTQAERVYALVNTTSDALMQLATTYSADEIAFIKRVLDAIFDTYNTRRCEAMVVSGIQAMQLAKASSDSSRRESQAATQQVQGGAAQSLTMSQAETVLKQLVEEGWLEKSRKGYYSLSPRGLMELRGWLIATYNENDEGRRVDKIKFCAACKDIITVGQRCGNRDCSGRLHDMCTHNFFRMRQAEQCPVCKAPWPGDKFVGERAITNTEASMQGRRRSTNTERESGAGSSTQVASQVTNRDNESD
The following text describes a protein:
Function:
May be involved in sexual development.
Subcellular Localization:
Nucleus.
Sequence:
MAGNLLRGPPLLLRAADKYPRTPKCARCRNHGVVSALKGHKRYCRWKDCMCAKCTLIAERQRVMAAQVALRRQQAQEENEARELQLLYGTAEGLALAAANGIIPPRPNYEVFGSVSSESNSESSIPKYELFPKSQLSSSTPPQQSGGKPVSAESDSAPGISSPDARHEGGSGSENGDSESFINSPVSKPLKDGEETPGSVSSLGSDSGSEIDKDEQEPSPSSVASRHMNAIDILTRVFPSHKRSVLELVLQGCGKDVVQAIEQILNNGGAQAPKAGAEETWTAERMLQSAQQLPAASATTAPSSRPMLPGAMALSNRSAFSPLQPNAPHFGADPGSYPLGTHLGLNPLRLAYSAHSRGLAFMTPYSTTGLMPTLGFRPPMDYAFSDLIRDRTMLHKEQPYASGLYGPLVNNTPDKQ
The following text describes a protein:
Function:
Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control.
Sequence:
MSNRDAQQDFRLLLEELYRERTLRFFKAGQSIPLRNQEIWIVYRGLVQLATLQPSGDEALLGLAGSLMPLGRSLTLLEPYHAVALTNVDLLRLTTEEIHSSPRLARELTEQMARRLRQAEALLALAGKRLVIDRLQGFLYLLAHEFGHPTGEGIRIDVRLTHQQFANALGTTRVTVTRFLGELKYRGLIEIGADRRIYLKEPQRLAAASCF
The following text describes a protein:
Function:
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Subcellular Localization:
Cell membrane. Cell projection, axon. Cytoplasmic granule. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Synapse.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
PFNGDGGPELLQNVFYSEKQHLSFILASSGLNRRGEGGGPEQNGHPPAARPAVQEAEEDEDEEMTLKYGAKHVIMLFVPVTLCMAVVVATIKSVGFYTRKDGQRLIYTPFPEDTDTVGQRAVNSILNATIMITVIIVMTLVLVLLYKYRCYKVIHGWLFLSSLFLLFFFSYIYLQEVFKTYNVAMDYFTVVIVIWNFGVVGMMCIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLLAVLCPKGPLRILVETAQERNEPIFPALIYSSTMVWLVNMADTGGPRRESAEETQEGELSPQDDGGFTPSWVSQQEHQLGQLQSTEETRRQIQQMPSARPPAEEDEEERGVKLGLGDFIFYSMLVGKAAASGDWNTTLAFSACVGLQPFMDKLALHQFYI
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKVWKTVRFIVGAVLVMADASNAEGSLANEREFATLCGFVSLTHQIRESLYKVREKSEVDVILLQKKVADILFGTGISDVGSMKWKQYRQQDCGQDSGGRTFPGGETLVKDLICLCDGTDLQPRRDALCYAENTEQSRYTGWKNTLNHEKTWSRLQGKCEADHREGTPTRAEFEKKKEQLRSGIKGRKDKEGTYYTYGGNAKNGLQICNGIATTEADGICVLYKRGSDGDNTSGIEWLNKLEELVKIVEGMDQSTNSDAKTVVETETKEKPKENPKENPPSGRRDESTQGGSRYTPTATSTEANVSPARPAGEQKSYSQVISIPLRVLFSLIL
The following text describes a protein:
Function:
Like parvalbumins, SCPs seem to be more abundant in fast contracting muscles, but no functional relationship can be established from this distribution.
Miscellaneous:
MISCELLANEOUS: The sarcoplasmic calcium-binding proteins are abundant in the muscle of arthropods, mollusks, annelids, and protochordates.
Sequence:
MAYSWDNRVKYVVRYMYDIDNNGYLDKNDFECLALRNTLIEGRGEFNSDAYANNQKIMSNLWNEIAELADFNKDGQVTVDEFKQAVQNLCCGKSFDGFPPCFKTVIGRLFKTIDINGDGLAGVDEYRLDCISRSAFSSVKEIDDAYAKLCTDDDKKAGGISLNRYQELYAQFISNPDEKCNAVYLFGPLKEVQ
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MSKDLEVAGRYANALFQVAQDKDLVDVFSEELTELKAALKANKDFVKLLENPTFTTEQKKNLASAVFEKINPTLRDFIYLLIDRSREDYLSVIADVYQKRVNDLRGVADADVYSVVPLSEQELTALSRVFATKMNKTKLNIQNHIDKSLLGGVKVVIGTRIYDDSLKTKLKDMERQIKA
The following text describes a protein:
Function:
Stimulates translation by blocking the activation of the dsRNA-dependent protein kinase EIF2AK2/PKR, thereby inhibiting the host interferon response. Sigma3 prevents the activation of EIF2AK2 by competing with the kinase for dsRNA-binding; The viral outer shell polypeptides, of which sigma-3 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3.
Subcellular Localization:
Virion. Host cytoplasm. Host nucleus. Note=Found in the outer capsid. Each subunit is positioned with the small lobe anchoring it to the protein mu1 on the surface of the virion, and the large lobe, the site of initial cleavages during entry-related proteolytic disassembly, protruding outwards.
Sequence:
MEVCLPNGHQVVDLINNAFEGRVSIYSAQEGWDKTISAQPDMMVCGGAVVCMHCLGVVGSLQRKLKHLPHHRCNQQIRHQDYVDVQFADRVTAHWKRGMLSFVAQMHEMMNDVSPDDLDRVRTEGGSLVELNWLQVDPNSMFRSIHSSWTDPLQVVDDLDTKLDQYWTALNLMIDSSDLIPNFMMRDPSHAFNGVKLGGDARQTQFSRTFDSRSSLEWGVMVYDYSELEHDPSKGRAYRKELVTPARDFGHFGLSHYSRATTPILGKMPAVFSGMLTGNCKMYPFIKGTAKLKTVRKLVEAVNHAWGVEKIRYALGPGGMTGWYNRTMQQAPIVLTPAALTMFPDTIKFGDLNYPVMIGDPMILG
The following text describes a protein:
Function:
May function as a transcriptional regulator.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May result from the retention of an intron.
Subcellular Localization:
Nucleus.
Sequence:
MLGHRLLPSLDFPAVSEGYKPEHDMSPNKDASSLNSSAAGLVCLPPVSEELQLVWTQAIQTSELDGNEHLLQAFSYFPYPSLADIALLCLRHGLQMEKVKTWFMAQRLRCGISWSSEEIEETRARVVYHRDQLLFKSLLSFTQQSVRPPQERPPVLRPEQVALGLSPLAPSEQPTHMKGLKVEPEEPSQVSQLPLNHQNAKEPLMMGSRTFSHQSDCQDLQISGLSKEQAGRGPDQSCGKTASWNHFTAVHQPDKPASVSLLDNSCKEESEPSGIPPSSSTSSPSFQALANGTTATPKPLQPLGCISQSLSPSKKALSPQVEPLWPQRLWNNSEPNSAGPTEYLSPDMQHQRKTKRKTKEQLAILKSFFLQCQWARREDYHKLEQITGLPRPEIIQWFGDTRYALKHGQLKWFRDNAVLGTPSFQDPAIPTPSTRSLKEWAKTPPLPAPPPPPDIRPLEKYWAAHQQLQEADILKLSQASRLSTQQVLDWFDSRLPKPAEVVVCLDEEDEEDEEDELPEDGEEEEEEEEDDDDGDDDVIIWD
The following text describes a protein:
Function:
Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MLELDKLDVARVSWLQSLVSHRIVPVAFAKHLYKRCCTIVNATYNEEAYRAMFDEAAKHLSSVDLELRTFRDQQSGQTMLALVNTKADTLIQGATRYSAPEIAFIKKLIEEIFKARREAYAIASLEAVRLGSKLRTHLTRDATEELLKNLVDHRWIDYSTEGIYTLSTRSLLELRNYLQNEFGEEYCHTCSHCKDLVTLGIGCVNISRGCTTRYHLHCARSTIGSAVDDDDALHRLAGFSCHNCMRTWKSRPIGPRALKLSTGGDHDGVLSPQRERSGRESPRRRQTSHASEEQQEEAEEDQEEVLATQQQNRESREYPEDEQEHDEPTPPSSTQPNQQQTPLQQRSRRRKQADNVEEDSDQELDITSRKRAR
The following text describes a protein:
Function:
May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Sequence:
MIIENVDALKSWLAKLLEPICDADPSALANYVVALVKKDKPEKELKALCADQLDVFLQKETVGFVDKLFECLTTKIYLGNTAPKEAPKEEVQAPAVKTEGEEGAVTEGPEEERENRRRRSPLRNRPEFNDSRSRDDRRRDERKRRDFERQGKGGDSHRDRERHERRRGSPRGRSYSRSRSGSRGKSRDREHRGGRDFKSKFEVERKDQDGYNSSATSGSQQQQHASPLLPLPTPPHPFPPSSSAGATGAGGVSVATSAHLPDSTTDSWSGYYAAQRKDGVSKAFGNKGASLKQRCRDYDEKGFCVRGDLCLFDHGNDPLIVDDVNLPNMIPFPPPPVMPPPGLPMPPIPEPPPSLRMPSMPPYGHPPPGVFPMARPPLIPTSGIDSPNHQSAVTPSPLIRPPLVGLRPTLPPHPPPQPPPSSSTVSLRPQYIQSEYNYDPEGYNPESPGLTAPGPNSYRQFIPRVQSQRSNLIGLTSSEGQVSRAANIVIQTEPATGVGAPGANASRFNTEQDSRKRSMGAITAEGPVMKKPWMEKSNFNNRHKGIFPKRNYYMNTKLEVRRIPPELNNITKLNEHFSKFGTIVNIQVVYGGDPRAALIQYTKNEEARRAISSIEAVLDNRFICVYWHREPDTNSAGLQQQEQSLGNQGPGATPGQGLQHINMHKGIKQHNAATYVLNNIPPKHQQNATAGPTNPSKTDNLTPTSDTATVAPGHTNTQKGPYTSTALKPSSKSLGQTGKALEAQEALKKKQEALKLQQDMRKKKQEMLKTQIECQKALINRLEKNRSMKPEERANIMKTLKELTEKISQLQNEMNAASQVSGVKTSPNQPKTKTDQTHKELLDAELEIHKKMSSGEDTTDLKRKLGQLQVEATRLGLIRPPAGRGRGRGKMLQGPGAIHGGRGRRDMAARGGLVNRMVIDHRPRALVILGVTQEEKEELRLHFVKFGEVEELGDQDANSLILTFRTRSEAENAANQGAKFKGRMLQISWYKPKTPSVTTEPEEEEAKDEDSTKDASSYLPGEDRDEEEEEEDDDEDDENESRSWRR
The following text describes a protein:
Function:
Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins).
Subcellular Localization:
Cytoplasm. Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Lumenal side. Secreted.
Sequence:
MPPSGPRGTLLLLPLLLLVLLRAVLAVPLERGVPNKEEAPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLTSTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQQQQQQGHKDPAAHPEGQLKFHPDTDDAPVPAPAGDQKEVDASEKKLVERLPEVEAPQHL
The following text describes a protein:
Function:
Involved in spliceosome assembly; Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1.
Subcellular Localization:
Nucleus speckle. Nucleus, Cajal body.
Sequence:
MELGKKLREVGWYLTEEGLKIVTTAVGSEDVRKIVNDALNRDLRDIGGGALPAKREDATLPGKIVLQVQRVRNIAAPKANEESKAAPRLLQLDLSDGQNSIKALELEPVPQLNLNVAPGSKIYFKAEKLQLMQGFLLLKSSEIQLLGGRVDALYEKWDLARTMMRYARSGRPLNGTSAPPPWVAFGRKIDSNAESEMNFKSLGEGDKDKPAKENEEFNAMRTEAIAVATKAGGKKIFGGGGQNIIDHNVKKILDKGFSEEEARSALSATRNNLERALYNLKRRSEAGGVGPIESVGRPGRGDRPPREGKRGASAKDEVEAPKPAANTTLFDFLTNKLPAKETPAASNAETFAAAPTAAPTAPPTTNHFNPFKQYGSSRFSDSESKPSAMGGGGKFADRSRFENNVSSSFAAHRGGHVGSSRGGGRNRGGGRDERPPREERAYREDRPPREEKPPKEERPPRERGAFNDRAAGRYKPETPTVKTANRNGSDNVSLKPNSEIKPDHETTNGKDHTGNRRGSERGSNRGGSNRAENGNANGNRRNKPAASLTSASSAAKSTNSAGDDFNARLSKITEETANLKVSSAPKRENRRKQGGQANRLAGSGTETTQQQQPAQLHSQKPEKAQTNQKHHNPRHNSQANYSQLANGYTYDPSKIMGFQSKEANEFAMNLLKSQGVTLPNEKQQEEEQQESPPMSFGPVSAPVSRAQPAPVAVPQAAPRDQFGMVPGDAWMWQKGDLCMAKYWDDGRYYEAEITGVSEKTCVVFFMGYGNHEEVLKVDILPITDAQNRPLSNSAQQQQPHLQQQQPHLQQQQHSRYRGDRQTQQQQVYVPPHKREH
The following text describes a protein:
Function:
Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.
Sequence:
MDYITLNPQESGDHIMKTAKHVKVDLEKCKEAALLVMDAVVEGKIGEIDYSANPLHPSGLSDEEKMLWVFLLDVLNFSFWPDEGEEYNVTFEGQTYTGYLAMCAAFRKAHKELNAPIATVQWMLTVDVGVLDFILKDDKGFSIPMITQRKQAVKEAGEWLFWSHDASFLNVVRKSNCNAQVFLRYILACESFRDYGFYNNRKVSFFKRAQILINDTVGALIGSEENKHLVDFKDLDTLSMFADYRVPQALNYLECLEYSPELLDELQSNKLLTYGAEKEVEIRGASIYAVQQMYKEIQRVRAAGPYSECDVDTVSGEYRLMGATGGDMDFTNARRLLPIDIDVWLWMFRREHADEVESIVPFHRTRSIYY