lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway.
Miscellaneous:
MISCELLANEOUS: Present with 2190 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MLEALFRDSVEEAINDSIKEGVVLAVYNTARDDQWLKSWFKGDDVSLDTLAEHSIWLRLVKDTEQFQLFEQVFPNVVVPSIYLIRAGKIELIIQGEDDRHWEKLLACIGIKDKKAGESSSRETNPGLAREEKSSRDVHRKNARERIAETTLEIQRREQLKQRKLAEEERERIIRLVRADRAERKALDETHHRTLDDDKPLDVHDYIKDAQKLHSSKCVLQIRMTDGKTLKHEFNSSETLNDVRKWVDVNRTDGDCPYSFHRGIPRVTFKDSDELKTLETLELTPRSALLLKPLETQNSGLSVTGMEGPSLLGRLYKGFSTWWHNDKDPEVTSQREETSKPNRHEVRSSTPLSGAASSSCFQYNNVREPVQSSAHASPMLTPSGTRYPSETNLTTSRSVSPNVFQFVNNDHQEDPEDPTTFNGNNVHLEKKKDEDKK
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
MDGASSSSDSFPLLETADWFQELSLGSDASEVPRNHYKGSLQNQYGHVPSGAYTAPSSHGNERRPSMNGGDPFGSYPWGYHPSGGYQDQSFGYGHNNNSNTLSHLMMDPHNSSFDQFGYSDHLYSNHGLYGLYGNVIDSGHAYGTFGYDSWKLGRGWYPVDGYRKTKSFNYARGYSEEKADRLNELCRGPRSSDVKKQDAPVVDLHRYNGENFPETFTKERFFVIKSYSEDDVHNSIKHGVWSSTPTGNKKLNAAYYEAQEEECPVYLLFSVNASGQFVGVAEMTGPVDFNKTVEYWQQDKWIGCFPVKWHIIKDVPNSFLRHVTIANNENKPVTNSRDTQEVNVEDGTKIIKIFKEYMSKTCILDDFKFYETRQKMIRDKKIKQKKQVPDGASVETIH
The following text describes a protein:
Function:
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
Subcellular Localization:
Cytoplasm.
Sequence:
MNTGEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVITGSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTVISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKNVVVAGYGWCGRGIALRAAGLGARVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ
The following text describes a protein:
Function:
Outwardly rectifying potassium channel protein; activity is sharply augmented by increase in temperature.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAIVAQGVSTILTTFQKTFKGLLPLIILVAYTLLGAWIFWMIEGENEREMLIEQQKERDELIRRTVYKINQLQIKRQRRLMTAEEEYNRTAKVLTTFQETLGIVPADMDKDIHWTFLGSIFYCMTVYTTIGYGNIVPGTGWGRFATILYAFIGIPLTVLSLYCLGSLFAKGCKMLWRFFLKSTRVVSKDLSNKISEAADNIEEGTTAITPSAEKTENNDDDLLSFPISGLLLITVIWVIFCAVLFTFLEEWDFGTSLYFTLISFTTIGFGDILPSDYDFMPIVGVLLLIGLSLVSTVMTLIQQQIEALASGMKDNIDQEYARALNEAREDGEVDEHVDPEEDPENNKKSFDAVISRMNWSKRGLYYLLPDSQKKELAKQSEKKMGRKSIKIQTDNDLLETLIREEILKAELNNEMHKYTAPRSSHQPKLVYSDVREKEVPIEVVRVEHFNHGNEDYLEHDI
The following text describes a protein:
Function:
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MFPEVISVFGLKISLYGILVALGVLVGYFLVLKLAKREGLNTKAVENTFMIAVLFGVIGARIAYILEHPYEFHSLVDFLALWKGGVSFYGGLIGGIIGALIGIKVFNLPLWKSADIAAPAIALAHFFGRLGCTSAGCCYGKPFPYATSNEVGIHFSDKFPFFYVVFPKGAVAPPFTPLYPTQLMEAFGNLLIFFVLLFAYRYKPFSGFVFSLYLMLYGFERFFLEFFRGVTPPIPGIGLTWNQVVSLVLIAGSILLMFLLKNQKSNVVDYEV
The following text describes a protein:
Function:
Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.
Subcellular Localization:
Cytoplasm, cytoskeleton. Membrane.
Sequence:
MAEECSSRNDCSQESRQAEEKKPVKVENAAGTGSEFDGTDSDEKKNVPLAKKSRKRKYCIWAIACLDNWNKRGWRRNGKKSLEGADLREKYPLCIPVSVEKDAGSDIPDINMKKFLIPSDMLLRKFVRFLRGYSKKPMFVFFKNTTQPPTGVLMSAIDEENKDSDGYLHVIYSGNDHLSGLFEELKLSS
The following text describes a protein:
Function:
Disease resistance (R) protein that specifically recognizes the HopBA1 type III effector protein from P.syringae, and triggers cell death. Acts as a NAD(+) hydrolase (NADase): in response to pathogen-recognition, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death. In addition to ADPR, also generates a cyclization variant of cyclic ADPR (cADPR), termed v-cADPR, for which the cyclizing bond is unknown. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules.
Subcellular Localization:
Cytoplasm. Nucleus, nucleoplasm. Note=Forms aggregate-like cyto-nucleoplasmic puncta.
Domain:
The TIR domain catalyzes the NAD(+) cleavage (NADase) activity. In contrast to classical TIR-NB-LRR receptor-like proteins, only contains a TIR domain (Probable); The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence:
MTSVSPRYRNVPVPKVFLSFRGEEIRHGFISHLADALERYGIMFIIDKDEQRGNDLTSLLLRIKESKVALVIFSSRFAESRFCMDEIVKMKECVDERKLLVIPIFYKVRARDVSGRTGDFGKKFWALAQKSRGCQIKEWMEALECISNKMGLSLGDGRSEADFIKEIVKEVERVLATFTSEDTEDHHCQTVKLLKGLVVGCLAHQELPLVLVFTQVYYYVKFSIFFIEEIFSSCFRKGFVLKPCKEDLQINSISIPGIDLENFKNMMQQAMYELNQMLLQSLGNIDPHRDVAFENQPQDQPDSPIALPEERRVALEATKFCGHAAYWWNQTKTTRARIGKVLIHFWEKLKKKFKDTYDRTVRI
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MWLKSLLLCLYSLVLCQVHAAPSSGKQITSKDVDLQKKYEPSPPATHRGIITIEYFDPVSKSMKEADLTFELYGTVVPKTVNNFAMLAHGVKAVIEGKDPNDIHTYSYRKTKINKVYPNKYIQGGVVAPDVGPFTVYGPKFDDENFYLKHDRPERLAMAYFGPDSNTSEFIITTKADGNEELDGKSVVFGQITSGLDQLMDAIQYTETDEYGKPQHELRFLYFVLEILKISNILDLHAAYTEKVEKFRNGDVSVGSTLENIFRNDKAYTPLTTSTGTTAYDLNHPISRALMCLTVLGLCFIAYKGMHEKPHTVSLRHK
The following text describes a protein:
Function:
Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Involved in DNA double strand break repair, including the synthesis-dependent strand annealing (SDSA) pathway. Involved in DNA interstrand cross-link repair.
Subcellular Localization:
Nucleus.
Domain:
The N-terminal region mediates dimerization and homooligomerization. Both the helicase ATP-binding domain and the helicase C-terminal domain form intramolecular interactions with the HRDC domain in a ATP-dependent manner. The HRDC domain is required for single-stranded DNA (ssDNA) and DNA Holliday junction binding.
Sequence:
MSKKPVAQRKQLTLSSFIGLDGNSQSQPKSRAASVRSKPPAVYNPIFLDASSSDDETTEISSQSNNGTIATKKSSRDPRTAKLKKHTYLDLSVSPLAKLSAKKYARDSPKKPTSLDLSVSPLAELLAKKSDRDSPKKPVQNENSYTYRGLSESPVENKSIGDTLRKPPQKERKTSIVWLSDSPEKKVTQNERKILDSPLQRFSFEDFPNKENGNRHHLLTLPDSPPPPQPVKKPEKTMWQNETKTIQDKDSPANPLVSNNLASISTLLDSSRAPNTYKGSSRNLFEDSPEKSGSGEQGYKLGSAKENEIPTKPATASLERNSVTSSPSPAAPLKPRYSVAFDNSLADYLKDLAQNDNFSIDPNKQNTETLKSTLGFFRNTYVELMEKYCSLIDQIPAMHFNEIAGFQPNTFLKLKVMRQKFKARTQLVQNSLDKKESQLKAEQEALEKEEIEMQAEQAQQTVLSSSSPEKSRPIMPLPKVQEIKDEKIPNRNQLIHDLCGEPDNFSPPSSPRDTQLIPKRQQLINDLCGEPDDFSPPSKQNDPHLLRKCEELVHDLCEEPDDYLAQSMMLDGDLEEEQLNGPTQGTTTSGMDDDEDDLEGLLAEIEDEHQKMQGRRSEFNGYSYKELEAVKVKEKHKETPINISLDDDGFPEYDEAMFEQMHSQAAANKSRVSSAGPSTSKSVVPTKQTSALHSQKLSGNFHANVHNDGITGEFDGQKFEHSTRLMHGLSYSFGLKSFRPNQLQVINATLLGNDCFVLMPTGGGKSLCYQLPAILTEGVTIVISPLKSLIFDQINKLASLDICAKSLSGEQKMADVMAIYRDLESQPPMVKLLYVTPEKISSSARFQDTLDTLNSNNYISRFVIDEAHCVSQWGHDFRPDYKKLGVLKKRFPNVPTIALTATATPRVRLDILAQLNLKNCKWFLSSFNRSNLRYRVLPKKGVSTLDDISRYIRSKPQHFSGIIYCLSRKECDETSKKMCKDGVRAVSYHAGLTDTDRESRQKDWLTGKMRVICATVAFGMGIDKPDVRFVLHYSLPKSIEGYYQEAGRAGRDGDVADCILYYNYSDMLRIKKMLDSDKALQYNVKKIHVDNLYRIVGYCENLTDCRRAQQLDYFGEHFTSEQCLENRETACDNCINKRAYKAVDALEHARKAARAVKDLCSGRSRFTLLHIADVLKGSKIKKIIDFNHHKTPHHGVLKDWDKNDVHRLLRKMVIDGFLREDLIFTNDFPQAYLYLGNNISKLMEGTPNFEFAVTKNAKEAKAAVGSVSDGATSSTADGQSGMREIHERCYTDLLDLCRTIASQRNVTMASIMNIQALKSMAETLPITEKDMCSIPHVTKANFDKYGAKLLEITSNYASEKLLMQAVLDEEEEQAAAKQRPSTSGWNNESVDWDMAVASQGNANTSGASGFNSFRAGKRKKIYKSGASKRYKTSTTSPAARKTTSARGRGGRAGAKRAESSASSASGWKSKKTGNSFGFDLMPLPGSK
The following text describes a protein:
Function:
NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2. Can also catalyze to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release.
Subcellular Localization:
Cell junction, focal adhesion. Cell membrane; Multi-pass membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus.
Sequence:
MAVSVRSWLANEAGKHFVLMLWLAANTWLFLDTYLLYSTGQQYHYLYQMLGLGLCISRASASVLNLNCSLVLLPMCRSLLTFIRGSHTMSTRRMRRLLDKSKSFHVACGIAICIFSAVHVSAHLINVVNFSAGFSEDFPALNLARYKGEDPKLIIFTTIPGVSGVLLVLILLLMFISSSHCIRVCNYEIFWYTHNLFIVFYIILMVHMAGGALKFQTNIEAHPPGCLRASQSLRQQQQAEDLDQKQRCKEDAHFQPHYPQTWLWVSGPLCLYCVERFYRYIRSSHPVTIVTVIRHPCDVVELRMLKKNFRARPGQYILLNCPGVSPFENHPFTLTACPTENKQTFGIHLRIVGDWTEHFAHLLLPQPRAALEILPVVHQRRYPTLYVDGPFGSPSEEVFNYDVSLCIAGGIGVTPFACVLNALIERWQSFRLQRLYFVWVCRELQSFYWFAELLCALHEKLWQDNRPDYLNVKLYVTQKDSLQSMSELRYRPLAARLQVGRPKWKLLFDEIGKSNKDKRVGVFCCGPKGISRTLHRLCNSAKSSGATFEFNKESFS
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MFTTLMYRTAAVSMTVYITNRVGVWGKTEETDHLLDQITNGLQPVFGLLRRTLKLDESDLSVGELSRKYYNEGVKGTFRIIRNIPNYSEELADGAKVTCLDLVEKAKELRHKEYSKWWNTSTNKEQLIIDSPDSAAGDGSFEDLVPFEKPKTVDNFAGEEGNGALEQRV
The following text describes a protein:
Function:
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid (By similarity). Promotes oxidative stress resistance.
Subcellular Localization:
Secreted. Endoplasmic reticulum. Golgi apparatus.
Sequence:
MTRWSMSMHCTLFLLFLLRLTCIFSDSDYLMGLGSYDITGPAADVNMMGYANMEQVASGVHFRLRARAFIVAEPYKKRIAFVNLDAGMASQLVTIKVIERLKQRYGELYTEENVAISGTHTHAGPGGYLQYILYLVTSLGFVHQSFNALVDGIEQSIIQAHENLRPGSILINKGELLDAGVNRSPSAYLNNPAHERSKYEYDVDKEMTLVKFVDDQWGPVARIMEDWFERENGCRSVDVESPRRVSSIISDPYDQDLMEMASSLLSTGGKTVTRMSSVARRVRSRFRHADKPRFVSAFCQTNCGDVSPNVLGAFCIDTGLPCEFNQSTCGGKNEQCYGRGPGYPDEFESTRIIGERQFKKAADLFTKASEEIQGKVDYRHAYVDFSQLEVTINGQNGGSEVVKTCPAAMGFGFAAGTTDGPGAFDFKQGDDQGNPFWRLVRNLLKNPTEEQVRCQRPKPILLDTGEMKQPYDWAPSILPVQILRIGQLVILCVPGEFTTMAGRRLRDAVKTVLKEGSNGREFSVVIAGLTNSYSQYIATFEEYQVQRYEGASTLYGPHTLSGYIQEFKKLANDLLSAQTTDPGPQPPDLLHKQISLLTPVVADMTPIGTAFGDVTSDVPRLSKFRKGADIVRVQFRSANPRNDLMTEGTFALVERWLEGRETWVPVYDDDDFCLRFKWSRPFKLSTQSTATIEWRIPETASPGVYRITHFGSAKTPISSIHHFSGSSSAFVVY
The following text describes a protein:
Function:
Mediates the nuclear localization of RNR2 and RNR4, 2 subunits of the ribonucleotide reductase.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDAQLEWASSLVPKRQLQQQQQQQEQQQQQQQDFHKDQLMTVGMRIRQRVDQGYASRTPSTSDASLQPGVIRDYSSVIVPQFTRSPLPTANSLPPMLINQRTMSTEASSLEKWDVAEPAAEHETMVNGSKRRL
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MVRPRVSLAPNRLNHAGSELDEKIAAKKRELQQLVQLRQYSSDLADELEGLVQHVSCLAEETDVVAEVMGNWAAVIRAINLASTALARYTEEDYREPVLPEQLIRVPLEDEQEE
The following text describes a protein:
Function:
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.
Subcellular Localization:
Nucleus.
Sequence:
MLIFSAFKTLTGQQVTIELKNDLAIQGTLKSVDQFLNFKIDNIRVLDEAKHPHMMAVKSAFIRGSVVRYVHIPAAAVDTQLLEDATRREAASQAKR
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication. DOC1 is required, together with the coactivators CDH1 and CDC20, for recognition and binding of the substrates.
Miscellaneous:
MISCELLANEOUS: Present with 1364 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDPIGINKVLDHLAPSELIKPVKSCHNKPSVLVLDDRIVDAATKDLYVNGFQEEIQYQNPTPENLQHMFHQGIEILDSARMINVTHLALWKPSSFKLGNPVDFALDDNYDTFWQSDGGQPHQLDIMFSKRMDICVMAIFFSMIADESYAPSLVKVYAGHSPSDARFYKMLEVRNVNGWVALRFLDNREDDQLLKCQFIRLLFPVNHENGKDTHLRGIRLYVPSNEPHQDTHEWAQTLPETNNVFQDAILR
The following text describes a protein:
Function:
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).
Subcellular Localization:
[Pro-neuregulin-4, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active; [Neuregulin-4]: Secreted.
Domain:
The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity); ERBB receptor binding is elicited entirely by the EGF-like domain.
Sequence:
MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH
The following text describes a protein:
Function:
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MIPKKTKLKSREIEVPGDKSLSHRSVLFAALSKGKSKVTGFLEAEDPLNTMSAFAKLGLKVQKVKPGEYEFESPGKNKLVSPNVDLDFGNAGTGIRLSAGLICGLPGINATLTGDNSLKKRPMGRIIKPLSSMGASIVGLGEKETAPLKIEGKKLKGFRYESPIASAQVKSCLMLAAISSETDLEYSENILSRDHTENMFRFLGNKIEQISPLHFKIKPPYVLNGGEFRVPGDISSAAFFLVLGVLAKEGNLLIKNIGLNPARTGILTALQSMGAKIEIQNKRIECGETVGDLKTYPSNLKKSNIPESLIPSIIDEIPILSVAGFFAEGGFEIRHAEELRAKESDRIHTMVSNFRELGIEVEEYTDGYSFDGTSKKSSEVWTRLSTVKKIPIQSYMDHRIAMSFLIFKTLSGLDLQIDETSWIETSFPGFEKLLESCINE
The following text describes a protein:
Function:
Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Presynaptic active zone.
Sequence:
MLQLRDTVDSAGTSPTAVLAAGEDAGAGRQGAGTPLRQTLWPLNVHDPTRRARVKEYFVFRPGTIEQAVEEIRAVVRPVEDGEIQGVWLLTEVDHWNNEKERLVLVTDQSLLICKYDFISLQCQQVVRVALSAVDTISCGEFQFPPKSLNKREGFGVRIQWDKQSRPSFINRWNPWSTNMPYATFIEHPMAGMDEKTASLCHLESFKALLIQAVKKAQKESPLPGQANNVLVLDRPLLIETYVGLMSFINNEAKLGYSMTRGKIGF
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear.
Sequence:
MATNYSANQYEKAFSSKYLQNWSPTKPTKESISSHEGYTQIIANDRGHLLPSVPRSKANPWGSFMGTWQMPLKIPPARVTLTSRTTAGAASLTKWIQKNPDLLKASNGLCPEILGKPHDPDSQKKLRKKSITKTVQQARSPTIIPSSPAANLNSPDEHQSSHPSAGHTPGPQSPAKS
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors; This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.
Subcellular Localization:
Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Sequence:
MAAPNSRTGHVTVGQISREGPRFATSFPPTRQLGENFNMPLRLDIKRKLSARSDRVKCVDLHPTEPWMLAALYNGNVHVWNVESQQLIKSFECCDLPVRASKFVPRKNWVVAGCDDMQVRVFNYNTLERVHIFEAHSDYVRSIAVHPTQPYLLTSSDDMLIKCWDWDKKWACIQVFEGHTHYVMQIVINPKDNNQFASASLDRTVKVWQLGSSAPNFTLEGHEKGVNCIDYYHGGDKPYLVSGADDRLVKIWDYQNKTCVQTLEGHAQNISSVSFHPDLPIIITGSEDGTVRIWHASTYRLESTLNYGLERVWAIANMRGTNNVALGYDEGSILIKLGREEPAMSMDANGKIIWAKHSEVQQANLKAIGDTEIKDGERLPLAIKDMGSCEVYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQEFVWAQDSNEYAVRENSTTVKLFKNFKEKKSFKPDFGAEGIFGGFLLGVKSANGLAFYDWENTDLVRRIEITPRHIFWSENGELVCITTDESFFILSYSAERVSNAMATNEGVTEDGVEDAFDVIGEIQEVVRTGLWVGDCFIYTNSVNRLNYYVGGEIVTISHLDRTMYLLGYIPKDNRLYLGDKELSVVSYSLLLSVLEYQTAVMRRDFDTADKVLPTIPKEQRTRVAHFLEKQGFKPQALVVTCDPEHKFELALQLGELNTAYELAQEAQHEQKWKQLAELATSKCQFSLAQECLHHAQDFGGLLLLATSSGNAGMVEKLAKSAETAGKNNVAFMSYLLQGKLEDCLELLIKTDRLPEAAFLARTYLPSQVSR
The following text describes a protein:
Function:
Probable non-catalytic subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, FIP37, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing.
Subcellular Localization:
Nucleus speckle. Nucleus, nucleoplasm.
Sequence:
MKKKQEESSLEKLSTWYQDGEQDGGDRSEKRRMSLKASDFESSSRSGGSKSKEDNKSVVDVEHQDRDSKRERDGRERTHGSSSDSSKRKRWDEAGGLVNDGDHKSSKLSDSRHDSGGERVSVSNEHGESRRDLKSDRSLKTSSRDEKSKSRGVKDDDRGSPLKKTSGKDGSEVVREVGRSNRSKTPDADYEKEKYSRKDERSRGRDDGWSDRDRDQEGLKDNWKRRHSSSGDKDQKDGDLLYDRGREREFPRQGRERSEGERSHGRLGGRKDGNRGEAVKALSSGGVSNENYDVIEIQTKPHDYVRGESGPNFARMTESGQQPPKKPSNNEEEWAHNQEGRQRSETFGFGSYGEDSRDEAGEASSDYSGAKARNQRGSTPGRTNFVQTPNRGYQTPQGTRGNRPLRGGKGRPAGGRENQQGAIPMPIMGSPFANLGMPPPSPIHSLTPGMSPIPGTSVTPVFMPPFAPTLIWPGARGVDGNMLPVPPVLSPLPPGPSGPRFPSIGTPPNPNMFFTPPGSDRGGPPNFPGSNISGQMGRGMPSDKTSGGWVPPRGGGPPGKAPSRGEQNDYSQNFVDTGMRPQNFIRELELTNVEDYPKLRELIQKKDEIVSNSASAPMYLKGDLHEVELSPELFGTKFDVILVDPPWEEYVHRAPGVSDSMEYWTFEDIINLKIEAIADTPSFLFLWVGDGVGLEQGRQCLKKWGFRRCEDICWVKTNKSNAAPTLRHDSRTVFQRSKEHCLMGIKGTVRRSTDGHIIHANIDTDVIIAEEPPYG
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLTFITEIFSTPAFILGIIAAIGLIALRKTGSDIVKGTLKTIFGFIMLQQGSAIIVGSLIPFSTMFENAFQLKGVVAEDNAIAAAVQQILGTETSLILVFGFIINVILARTTRWKYIFLTGHMMFSFAATMAIVFDQMGFNSWQIILFGSIAQGISSIVFPALAQPFVRKVTGNDQVGFGFWGSSLVWATGWLGGKLGNKANSTEDLKVPKKLDFLKEMSVLMGIVMAVIYIFTSFFVDEPVMKELAGTQSNVLFAILQSFTFVVGILILLQGVRMFLGELVPAFKGISEKIVPGAIPALDVPVFYSFAPTATTIGFLCAVVGGLGATLVSTMLPVVVLPSVIGLFFMGGAAGVFGNAMGGRRGAIIAGLLLGFIFQMIVAIAYPILGLDGYGIQGLWFASTDAIIVIVIIRLIGALFGIAL
The following text describes a protein:
Function:
Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.
Subcellular Localization:
Lysosome.
Sequence:
MTADKPKGRMGPRSGLLGLFALFVAGKCSYSPEPDQQRRLPPGWVSLGRADPEEELSLTFALRQQNVKRLSELVQAVSDPGSPRYGKYLTLEDVAELVRPSPLTLHTVQKWLLAAGARNCHSVTTQDFLTCWLSVRQAELLLSGAEFHHYVGGPAETHAVRSLHPYRLPKALAPHVDFVGGLHRFPPTSTLRQHPEPQVPGTVGLHLGVTPSVIRKRYNLTAQDVGSGTTNNSQACAQFLEQYFHDSDLAEFMRLFGGDFAHQASVARVVGQQGRGRAGIEASLDVEYLMSAGANISTWVYSSPGRHESQEPFLQWLLLLSNESALPYVHTVSYGDDEDSLSSTYIQRVNTELMKAAARGLTLLFASGDSGAGCWSVSGRHQFRPSFPASSPYVTTVGGTSFQNPFRVTDEVVDYISGGGFSNVFPRPSYQEEAVTRYLSSSPHLPPSSYFNASGRAYPDVAALSDGYWVVSNHVPIPWVSGTSASTPVFGGLLSLINEHRILRGLPPLGFLNPRLYQKHGAGLFDVTRGCHESCLNEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLMNP
The following text describes a protein:
Function:
ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaL-ADP is converted to DhaL-ATP via a phosphoryl group transfer from DhaM and transmits it to dihydroxyacetone binds to DhaK.
Miscellaneous:
MISCELLANEOUS: Unlike the carbohydrate-specific transporters of the PTS, the complex DhaKML has no transport activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MTYDKDWALRWLNDFGERVQENKQLLSDLDQAIGDGDHGINMARGLSELKKAFTEKEPADLTDVFKTAGMTMVSKVGGASGPLYGTAFLNMSKAVDSETIDAEGLTKVIEAGLEGIEKRGKSHAGEKTMIDVWEPVVNALHQEDLTDDVVEAALQKTKDLKATKGRASYLGERSIGHLDPGAYSSALLFHAMLQTEVS