lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition; The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.
Sequence:
MESGPAVCCQDPRAELVDRVAAINVAHLEEADEGPEPARNGVDPPPRARAASVIPGSASRPTPVRPSLSARKFSLQERPAGSCLGAQVGPYSTGPASHISPRSWRRPTIESHRVAISDTEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQATQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGSLLMKEGCGEGCKSPELPGVQEDEAAS
The following text describes a protein:
Function:
Receptor for cAMP.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSSIIFIPNDADNINSIMVTISSSLSLVGCLFILSIYIYYKELREFQLKLIFIMTINDFIISIIFLIATHIQTKYFDAITNVFPFFCNFPDSLLHYFFLSSFFWEVCIAHTLIQVIKYNNDKVEDNLKKYFIFSNGLSALIMVSLFFIRSYSKIDCHHDSIFPHLLFFIPLLLTWIYNIIVCALLTKTFKEQAMNFGYSLGINGGSGSYINFTNNNSIDNYSNIIIKNDLIINNNNNINVNNNNNNINILFHVNVNNNNNKIIIKRIRKTPNIIWTSIFFLFSFGFIWSWSILVIILKYLSLDVKYILMISYFFIPLHGCMNAVCFGVNDRLRMNLKKSCKNYYYKFLGLFSLDKRKSYGINGNNKNNKNNNGANCEERSLIDYSPDDDDDEDDDNNNNNYSDGNYYQIPSPFLIDSRNSSNLTDYSVILDNNNNNNNNGPYNPTRSNSITELLYNNINSLNAIRILSNNNNNNNNNNNNNNNNNNNNNNINNNDNNNNNNNNNSFCTIDEDETK
The following text describes a protein:
Function:
Sperm protein required for fusion of sperm with the egg membrane during fertilization.
Subcellular Localization:
Secreted.
Sequence:
MTSLGSQLHRATFLTALLLLLLLQVKGVKTLIVSASLDGDKSQKDKVSSEDQGEEEYEEHFEASSEGEQWQEIDMVQQEDTISQAITLQDHLLDLAFCFNLASIMFFL
The following text describes a protein:
Function:
Serine protease which may cleave PFN/profilin.
Subcellular Localization:
Secreted.
Sequence:
MINRQYFIWYIFIFNIINKIYFENIRYVKNYEVVIRKKKNIERGIGNDFAFIRRYYKSRLLSDVSYKNNSIKGKNRVDKEGDIKKYDNNDDNKMDNSYDYKNKSIKENETKIRKEQVISLDKRYNRNINEKEEIKKKIKDIQRKRLIIYFKQDNTILSSRNYKHIFMKVLSSCGHIEKLTFINFYLYEFPKSINNEDMLLKICLRLLESRRINVENDNQISHTVQMKSYNNNNNKWDNINSKNNCIYQIKDKIKDLPNVSPSASTFTSISTSPYTLKLRDRNKYANDKNHIFKINHSNKHKNNNNNNNNNDYHNNNKSNYHSHSSAKCQTQRLNKKMIGTNILDGYDIIQMEEGLNLSHNYELNDVNVCIIDTGIDENHIDLKDNIIEKKTFMKHSYKKYNIDGINNIESDNIDGINNIESDNIDGINNIESDNIDGINNIESDNIDGINNIESDNIDGINNIKSSDNIKSSDNIKSSDNINSSDNIKSSDNNNVHTMLRNKLYLKKKKECSNYNTSNDGHGHGTFIAGIIAGNSPKGKKGIKGISKKAKLIICKALNNNNAGYISDILECFNFCAKKKARIINASFASTTHYPSLFQALKELQDKDILVISSSGNCSSNSKCKQAFQECNLNIQKLYPAAYSADLNNIISVSNIIQQSNGNIVLSPDSCYSPNYVHLAAPGGNIISTFPNNKYAISSGTSFSASVITGLASLVLSINSNLTSQQVIELFKKSIVQTKSLENKVKWGGFINVYDLVRFTIDSLPKDKDE
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MLQQPTISRFFKSSSTRKKSEQRTAKEEAELMQLLESDGENNSATVPSDRKPEAAPMHVGLGNKAAAGGAVPGQVKSATRGFEDFRFNRRREACGKEQEVGFAERLQRIMERREGGCVEEDETELDNEAPRSKRAKPNRLTELDQQFKDLKLQHMDKVLAVRVGYKYKFFAEDAVMVSRVLQIKLVPGKLTVHETDPADHKHKKFAYCTIPDTRLEVHLQRLMHHNLKVGVVEQTETSAVKKNSGTSSSVFSREVTNIFTRATYGINETFGTKDRRVLGDSASVWGLVCKRQPSYTRYFLVSVNLNSGEVIFDDFKEERFLTEALETRIKYTNPSEVVVGDGLGSEIEKVFHTSDSDITLNRIELVGLYEEIFSEPHPAFKGNVPLQTALMLVHGYLTNFKNESLLFFKENFKPFCSKTHMILPSSAIESLDIFENSTDRSSKGSLLWVLDHTRTNYGLRNLKNWIAKPLINIDQIQQRLDAVQCISTEVGNIFIESLNNMLRDGQDLERILNRIAYGKTSRREVYLFLRELTQLATLFSSHHRYIETNVLSANGKIRMQSSLLANIFTDLDEYWKQFPIPNFLAMINIDAALDKNPDRPYVEYFNLTKYDRAEPLISKQQDIEAVIGELRDELKNIRVILKRPMLNYKDEIDFLVEIRNTQVSSVPVDWVKVASTKAVSRFQTPGTAKLVAKLQYHKELLQDLALQEYESFIKRITGEYTSLRKAILHLSTYDCILSLAATSCNVDYVRPKFNTAPQCINVINGRNPIIESLDVRYMPNDVNLNREGKKIMIITGPNMGGKSSYIRQVALLVIMAQIGCYVPAQEAEFSIFDQIFTRIGAYDNLLRNDSTFKIEMTEMVQILRSSTENSLLLLDEVGRGTGTHDGISISYALLRYFIELHNACPLILFITHYASLGSIRSPILGNYHMSYIEEKRPGENWPSVVFLYKLKEGRAHNSYGLNVAKLADIQTGIINRAYKISTMLKQEMESNSSIAAICTIKHALAGNSAASLKSAIETLIESADHEQFVLNM
The following text describes a protein:
Function:
Purine salvage pathway enzyme which catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of hypoxanthine to yield IMP (inosine 5'-monophosphate). To a lesser extent, can also act on guanine leading to GMP, but shows a highly less efficient activity with xanthine.
Subcellular Localization:
Cytoplasm.
Sequence:
MKHTTEVMISAEEISKKLDQMAEQINAHYANSERLLMVGLLKGSVVFMADLCRRIKGHVEIDFMSVSSYGNAMTSSRDVKVLKDVQSDIADRDVLIVEDLIDSGNTLNKVREMLLLREPKSLALCTLLDKPERREVDVKVDFIGFTIPDEFIVGYGIDYAEQYRNLPYIAKVVPLE
The following text describes a protein:
Function:
Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity).
Subcellular Localization:
Secreted. Bacterial flagellum.
Sequence:
MAGELYFSGVTGAYDWGSVLDNIMAVKSIPIQKLQQKKQLINQKLQILGEFSQKLSDLKNLIENFNLESALKTKKADVSDSDVISVSVSENAPEISFSVNVLNTASKEILVYDAGFNSLDETIGSDGSFTLRYYTSPTDYVEYTIDYSLIDTLKDIVNKINETQDYVKASIYYDGNKYKLMLAETSEENSTVETAPDLSTKAIHLLGTLPHQFGNNVLIQQAKNARIQIGSGDVIESAGNTFENVIEGVSISAKRAGTSEVSISQDFSKIREFLNNFVKSYNEVVSQVKSLTLGENAPFRGENTIMNVKYGLSDTLTPLMELGLIEYKEDGTISLSGNLESVINEKPDEFKLKMTQFLESAKAVAKVNYEAFEDFKEYLNDQAERIDENIRLLSQRLVQEEQILKRQFAQLEDFMNYANQIRERLKQFMVSISEMNGGNNK
The following text describes a protein:
Function:
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. Plays a role in maintaining homocysteine homeostasis. Involved in cold-induced somatic longevity mediated by prostaglandin E2 (PGE2) signals from adult germ cells, perhaps acting via a role in the production of hydrogen sulfide (H2S). Required for normal development.
Subcellular Localization:
Cytoplasm.
Sequence:
MIQNEVSATHGSTKKGITYNTILEAAQRPTPLVPLKKLKVEHQLQSDIYVKLEYLNIAGSLEDRTADKAFQFAEEIGVVRGDEVFVTAGGSAAISYATVAAVKGIKLTIYAPKGEFDLVDTVLHTLGVKTVELPFGTFAEARVQTDEAAQQKGVFSLNKFTTNAAFVANLQKTALEIEKAVNNKSIGKVGAVVIPLNTGAAAAGIAAYYKGIGEHGVRVVGVTCKKDTIPEMGLDLKNDLLQEYNVEKREVEEDEAYSFTRHLIGTEGIMAGPSSGAAVLEAIKLAKELPAGSTIVVVLMDGIRNYLRHFLDDDWITANKKDVVTRKDGPQPNSIYDPKVLVYDPTKLAGEWTQDPETKSWSHSEVEFNKFNPERPLVLDTVLDAIGKTPLVKLQHIPKAHGVKCNVYVKCEYMNAGGSTKDRIAKRMVEIAEKTGKPGKLVPGVTLIEPTSGNTGIGLSLASAVRGYKCIITMPKKMSKEKSIAMASLGSTIIRTPNEAGFDSPHSHIGVALRLKSEIQDAVVLDQYCNPGNPLAHYEETAEEIIYDMGDKHIDLVVLTAGTGGTVTGISRKIHERIPTAKVVGVDPHGSILAGPAETDIDFYEVEGIGYDFLPGTLDTSAIDYWAKSHDKESFLMARELIRSEGILCGGSSGCAVHYALEECKSLNLPAEANVVVLLPDGIRNYITKFLDDDWMNERHFLDA
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSKLLLILLCFTVINLSNTTKTNIRGENEESGRKSSKNEEFYVGGIPYLADAISSLVWFIRGLLGFFYFIMNTVLLTVTQLAARALRILQNVVRFVEFIGYCVRVVMQANYNFVMSTFKSTKQYAQNCSEFIRHLFESTIDTFISMLRTACGLLHSVVVGIPRLFEFAGSVCKTSLQSAGSVAEKSYVKCKHVATTVASVPGSAAWEIINAINAVIQLIISTIINTFLILYDLSRAVFSFIRKTVVTIIKTFWSYLLRFLVQSGEVLEIVGYGMSKTATVITNSAYHGFDRIYNTVAYVIGTIYYGVITTIDNLLWVIKSIFSLMIRAVTTSLSGVHSALSETMKNIQNALYYLSSKFPGGKLSMISLVSIGMITYSVRFLFGLNVGVVCFDILEKAIQNFVSRINRRSIISQQVTVVAEEERPSTTLDNKPSVSNDEHVNRLREELERERDKTLCVICAEQPKQILIMPCRHMCLCSVCADTLLTHWNRRACPLCRCRIRSLIEGIVGKQNWKEAGKKIDSLTVILELPHKAALKSLAHLE
The following text describes a protein:
Function:
Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with which it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1. Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism. Regulates the circadian expression of cytochrome P450 (CYP) enzymes. Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSSQPGPCPCQGAAGHPTILYTLLSPRVRDRPSVAPARGRCLCRQHRPVQLCTPHRTCREALDVLAKTLAFLRNLPSFCQLPHHDRRQLLRGCWGPLFLLGLAQDTVTFQVAEVPMPSILKKILLEKPSNGAGSSQRPDRPQPSLAEVQWLQCCLESFWSLELGPKEYAYLKGTILFNPDVPGLYASSHIGHLQQEAHQALWEVLEPWCPAGQSRLARVLLTASTLKSIPPSLLGDLFLRPVIGDVDIADLLEDMLLLS
The following text describes a protein:
Function:
Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MGIEVKNLVKRFGNFTAIDDLSLDVPSGELVALLGPSGSGKTTLLRIIAGLEDADKGQVIFEGREVGKKNAKDRGVGFVFQHYALFRHMTIFENIAFGLEVRKRSERPSKDTIRDKVMSLLKLVQLENFYNRYPSELSGGQRQRIALARALAIEPRFLLLDEPFGALDAKVRKELRNWLRRLHDEIHITSVFVTHDQEEALEVSDKVVILRSGKIEQVGTPDEVYNHPKNSFVFHFLGDVNLFHGRVQGGQTQLGEIKVDTPEHSEIENASAVGYVRPYDVEILREPIEAQTIPAEIQYIHSTGRNVKIDLKRLDTGTILESQLNSSEFQSLNLLPGETVHIRFKKIKVYVEDYTI
The following text describes a protein:
Function:
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Miscellaneous:
MISCELLANEOUS: Heme 1 (or BH or b566) is high-potential and absorbs at about 566 nm, and heme 2 (or BL or b562) is low-potential and absorbs at about 562 nm.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MSKVYDWFEERLEIQAIADDITSKYVPPHVNIFYCLGGITLTCFLVQVATGFAMTFYYRPTVTEAFASVQYIMTEANFGWLIRSVHRWSASMMVLMMILHVFRVYLTGGFKKPRELTWVTGVVLGVLTASFGVTGYSLPRDQIGYWAVKIVTGVPEAIPVIGSPLVELLRGSASVGQSTLTRFYSLHTFVLPLLTAVFMLMHFPMIRKQGISGPL
The following text describes a protein:
Function:
Catalyzes the reversible oxidation of malate to oxaloacetate.
Sequence:
MTKVSIVGAAGTVGAAAGYNLALRDVVDELVFVDIPDKEEETIGQAADANHGVAYDANTDVVQGDYADTAGSDVVVITAGIPRQPGQSRTDLAGDNAPIMEDIGSSLAEHNDDFVTVTTSNPVDLLNRHLYESGDRDRHSVVGFGGRLDSARFRYVLGQRFDVPVQNVDATILGEHGDAQVPVFSKVRVNGTDPAFSADEREEILADLQESAMNVIEKKGATQWGPATGVAHMVEAILNDTGEVLPGSMVLDGEYGLDDVGLGVPVKLGSDGVEEVVEWELTADERDLLDEAAEKLSAQYDEIA
The following text describes a protein:
Function:
Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.
Sequence:
MPTGAPGFMPRRSSYASVVSGIAAGSSQQFGQPPRSGAFANLLNSNTHMLNQQHDSIYYDPNYNYATGRYGYGGFLGFDEENGNGGVNHGRSASWGRGGQLPSFSSAFGSLVNGHGHNGIAGHADHFFVPSYLKRSKYVQKLEEAHRAKVLAHRDGSSAPPSQPNSLSTSASSGNVHAKMVPSHRGRPYDLIEKSPLVEDETLSPLPSKWSTSDKFGALDVLSDGLEVKLTGPKSMNDRDNEASAIRTDHPMPPQCGIYYFEVTILSRKREDSSIGIGFSTKQVSISRLPGWEPDSWAYHGDDGHGYAGQNTGKPYGPSFTTDDTIGCGVNFSTGSAFFTKNGDHLERGKANQKGNSINQVLEHNLVTYSYAKTSLSTSKLHPPLSETELIQALVLQFLTHDGYVETARAFADEVHSEKKALNMDPNVTIPGFDIKDDEDAAHRQPILEGDIDQALKHTNAYYPQVLKDNEHVYFRLRCRKFIEMVRQMAEMHNTNSTNGSQKNTAHNGDWYDDIINHDMELDDHQAQANNWDRMETDGVNFETEYQNLLSETLSYGQVLQAEFKDDPRREVSKALEDAFSLIAYKDPINEKTVSHLLDPSGRVAVAEELNSAILLSLGKSSSAALEKVYQQTTILLEDLRESGGPGAFVNIDDYTRPKMA
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
MAGEKAEKPGTKEKKPAAKKADAGGKVKKANVKAKKANVKAKKANVKAKTPKKGKPHCSRNPVLVRGIGRYSRSAMYSRKAMYKRKYSVAKSRIERKKKEKVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHRGKRVVFLKQLGSGLLLVTGPLVLNRKQLRKPRHQEGEIFDTEKEKYEVTEQRKVDQKAVDSQILPKIKAVPQLQGYLRSVFALTNGVYPHKLVF
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
Sequence:
MPFCSYQEGLKVASDLGNKAIQTEASLSSLSPVASPIPTLQKAFPIYISAAEAYGHLLSSKLVPQSDIETVKRKWRLVLERAEKVKSRIEQLGGHVAKAEIGDRGEEIAVLRRASLINGVAVELWRPPGDTFDAGEPYREAVQPELAAAQLDMDPEWRDIQADCWLHQAPNEGDWVMRQGPVSDCSVVAAMGVGIKHAGQFGTAFGWENLYPQDAHGRPRRSKNGKHILKLLLNGAWRSVVLDSLLPFSKRDKTPLFTTCHPAPHILPTSVGSPWAPLALKGYFKVHGGYSLRGSNPSSDIYEFMGWIPERIGLKEGFQREKEWKRMKEAWHKGNVMVSLGTGSKVSEGLVKLHAYGVIRLREEGHERILDIFDPGATSFTMSWDQVCAEFEALHLNWKPSVMPNTATRHWSWPKPPDLPSDADPGMMNTRYRLHVNASSPSSSLSEVWILLSQHITSRDRPLDDIALHVFEGLGPNNSRNLGAIYSEGLERTNPYTNSNHLLVRYQLRRPTSDLTLIPSRDRGIDQTGFTLNAFAPASISLSLERISRTLPFTQRISGNLTDRSAGGHPGWPTHMTNPQYKVVVRPGEGKSEISGRIILHGEKDVPWNVKLIWGRGQLVYELSEDLIVADTGSYSYGIAYCDIPELQPDTYTLIVSAFEPGQTGLFSLSLEATAPVSIIPIAAEGAGMYNRVVNGFWTERTAGGRPSGGTYESNPRVEMVLSKPATIQSRLYLPTRSPVPINLTIFKRAQGGALGEQLVTTGPYSDSICGVSTGKMKLDSGVYLLVPSSYEKSKGGWVLKIWSDVALSAEIVG
The following text describes a protein:
Function:
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
Subcellular Localization:
Mitochondrion outer membrane.
Sequence:
MPQKIVVVGAGPVGSLAALYAAVRGHDVEIYELRSDLRNSEHSSNISQSINLALSERGINSLRKTGLPDLADAVLAETFPMHGRMIHVRKHGQYVRQAQAYDAHGRNLLAMDRTGLNKTLLDHLNSMPNVTFFFHRKLVSVDFRKKLAWFENRTKTDPAKSDDIEVSFDLMIGADGAHSAVRYHLMKFVPMSYQQEYIDKLWCQFHVPPSDKGDFRIPPNYLHIWPQDDAMFIALPNLDKSFTSTLFLTRSGFEELVASGKVVEYFDEKFPGVVPELITEDELRKQFNEHDHFPLISIKCSPYHFGSTGVIVGDSAHAMVPFYGQGMNAGLEDVRVLFEILDKYPGDQAKALSEYSEQRTPDAQTINDLALGNYREMASDVKKPLYLLRKWIEEKLYIYVPSAGWATQYSRVTFSNMRYSEVQAAAQRQAKILNGIVGVTTLSLIGSAALWLGRTGGLQQAKQNILRSICLLAQQAQKVTKG
The following text describes a protein:
Function:
Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MGTGGPRGRGGGEMPSWGRGRRGVPTYGRLGTELGTAGGRPREGRGGAEVGPEVGDGDGDGGLAVRSAALVSPQSMQVARLCLGLLLPAAAALEFAYHHQEQMEAFLKTVARNYSSITRLHSIGKSVQGRNLWVLVVGRFPKEHRVGIPEFKYVANMHGDETVGRELLLHLIEHLVTRDGKDLEITNLINSTRMHFMPSMNPDGFEAVRKPDCFYSNGRENSNHYDLNRNFPDAFEPNDVSRQPEAAAVMAWLEAETFVLSANLHGGALVASYPFDNGVPATGTSHSRSLTPDDDVFQHLAHVYASRNPTMKKGDQCKDKMDFPNGITNGYAWYPLRGGMQDYNYIWEQCFEITLELSCCKYPHEEKLPFFWNKNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYKTNKLGEYYLLLLPGSYVLNVTVPGHDPYLTKVVIPEKSEKFSALKKDILLPFRGQLDSIPVSTPLCPKIPLYRNLPSHSAATKPGLFIFLVTAFHIFVK
The following text describes a protein:
Function:
DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes.
Subcellular Localization:
Cytoplasm.
Domain:
Contains an N-terminal domain that binds non-specifically to RNA and a C-terminal domain that binds specifically and tightly to hairpin 92 of 23S rRNA.
Sequence:
MSTTSFSSLTLPAEQLSNLNELGYTEMTPVQAAVLPAILNGQDVRAKAKTGSGKTAAFGIGLLDKIAVGEFVTQALVLCPTRELADQVSKELRRLARFTQNIKILTLCGGQPMGHQLDSLVHAPHIVVGTPGRIQEHLRKKTLVLDELKTLVLDEADRMLDMGFSDAIDDVIAYTPPQRQTLLFSATYPSGIEQISARVQRQPLNVEVGDTDEEPAIEQVFFETTREKRLPLLISVLSHYQPASCVVFCNTKKDCQSVYESLESRGISVLALHGDLEQRDRDQVLVRFANRSCRVLVATDVAARGLDIKDLELVINFELAFDPEIHIHRIGRTGRAGMSGLAVSLCTPQEMVRAHTIEDYLQIKLKWTPAEQVSRSTNIMLEPEMVTLCIDGGRKAKIRPGDILGALTGDAGLTAADVGKIDMFPVHAYVAIRKASAKRALQQLQQGKIKGKNCKARLLK
The following text describes a protein:
Function:
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Sequence:
MSEYELPPLPYDYDALEPHISEQVLTWHHDTHHQGYVNGWNDAEETLAENRETGDHASTAGALGDVTHNGSGHILHTLFWQSMSPAGGDEPSGALADRIAADFGSYENWRAEFEAAASAASGWALLVYDSHSNTLRNVAVDNHDEGALWGSHPILALDVWEHSYYYDYGPDRGSFVDAFFEVVDWDEPTERFEQAAERFE
The following text describes a protein:
Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
Sequence:
MGSRHLLQEQNRGEAVGVMKQKNRRALGDIGNLVTLKPLDGKPLPEITRPVTRSFCAQLLANAQKDAAENKKKPLAVVNVNNNNNKNNKLEAKKKVAPKPKPAPVPQNTTVIEISPDTVEEKEKPQSSRSRNKKPQSSLTSTLTARSKAACGLNYKPKNIVDIDAGDVDNELAQVEYVEDIYKFYKLVENDNKVHDYMNSQPEINEKMRAILIDWLIEVHNKFELSNETLYLTINIVDRFLASETVARRELQCVGMSAMLIASKYEEIWAPEVNDFVQISDCAYEHKHVLVMEKRILGRLEWNLTVPTPFVFLTRFIKASVTSPEITMENMVYFYAELGMMHYGIIKFSPSMVAAAAVYAARATMNKSPVWHETLEVHTGFSEMQVLECAKMMGGFHLLARSDEKRKVIYRKYSSVTRGAVALYQPAKALLAVAN
The following text describes a protein:
Function:
NAD-dependent histone deacetylase, which contributes together with HST3 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance.
Miscellaneous:
MISCELLANEOUS: Present with 377 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MKQKFVLPITPPSTAEKKPQTENRCNENLKPRRLLPQLKKSVRNRKPRLSYRPELNSVFDLDAYVDSTHLSKSQRHHMDRDAGFISYALNYSKRMVVVSGAGISVAAGIPDFRSSEGIFSTVNGGSGKDLFDYNRVYGDESMSLKFNQLMVSLFRLSKNCQPTKFHEMLNEFARDGRLLRLYTQNIDGLDTQLPHLSTNVPLAKPIPSTVQLHGSIKHMECNKCLNIKPFDPELFKCDDKFDSRTEIIPSCPQCEEYETVRKMAGLRSTGVGKLRPRVILYNEVHPEGDFIGEIANNDLKKRIDCLIIVGTSLKIPGVKNICRQFAAKVHANRGIVLYLNTSMPPKNVLDSLKFVDLVVLGDCQHVTSLL
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 1600 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MLVRLLRVILLASMVFCADILQLSYSDDAKDAIPLGTFEIDSTSDGNVTVTTVNIQDVEVSGEYCLNAQIEGKLDMPCFSYMKLRTPLKYDLIVDVDEDNEVKQVSLSYDETNDAITATVRYPEAGPTAPVTKLKKKTKTYADKKASKNKDGSTAQFEEDEEVKEVSWFQKNWKMLLLGLLIYNFVAGSAKKQQQGGAGADQKTE
The following text describes a protein:
Function:
Catalyzes the dehydration of D-mannonate.
Sequence:
MSHNGSTTEEAASATQGGTMQAYFYQDLSDPASSPAVAARVRVPDTDNEQQSGMTLSNPNHIRPDGPRVCAFVGPAPTDQELQFVEQMGATHVFTWIEKLADMTPARLAALKDAVERRNLQLNNVGCLELAKCPDIILHTDNYAARLTQFGSMLAMLSEAGIHTTTFTWEASGKVYSTGQSVVRGGGLGRRCNARRLAALPVDPNAPTDEQLWSNLETFVRDVMPLCVQYNMVLALHPNDPPLRHVGGMPCLIRSFSDFERVFALDHSGRLQAEFCCGTISEGLRLPPAHDLAHVTADPALLGSFGDSCEALYSNLVAFVLRQRVAIVHLRNCTACLPDFAETYLDDGFLDIAHIIDLLVQNGYRGTIILDHTPPFNSVDGAAAATAFSLGYDLR
The following text describes a protein:
Function:
Plays an essential role in viral genome replication. Involved also in late/very late gene activation.
Subcellular Localization:
Host nucleus.
Sequence:
MPPKNCTHLGGCDSDCLTRSEIQALFREAINTLKHTMNTENVCAHMLDIVSFERIKEYIRANLGHFTVITDKCSKRKVCLHHKRIARLLGIKKIYHQEYKRVVSKVYKKQTW
The following text describes a protein:
Function:
Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.
Subcellular Localization:
Secreted.
Sequence:
MGAQLLTCTVSDSIRHQFSCFATSCCVLWVPKGVSTMLPPSQLGSQPPTSDPLSCQALLPRSLPGFTHMPPLSKFLVGLALRNALEEAGCWADVWALQLQLYRFGGVEATQALIRHLQELQKGGRADWKVSVNALSSALQLLAWEQAGPKRVKRSLSNMGCENEQEQRVHNVVELLPAVGTYYNLGTALYYAIKNCTDKAKERGRDGAIDLGYDLLMTMVGMSGGPTGAVITAALKPALKAGVQRLIRYYHDEEGVTTSQPETRKDAPTYRDDVEETTMSNLVSEVESTTSNWGRPLLKNYVFLAYKR
The following text describes a protein:
Function:
Catalyzes the NAD-dependent reversible oxidation of erythritol and L-threitol. Involved in the degradation pathways of erythritol and L-threitol, that allow M.smegmatis to grow on these compounds as the sole carbon source.
Sequence:
MSNQVPEKMQAVVCHGPHDYRLEEVAVPQRKPGEALIRVEAVGICASDLKCYHGAAKFWGDENRPAWAETMVIPGHEFVGRVVELDDEAAQRWGIAVGDRVVSEQIVPCWECLFCKRGQYHMCQPHDLYGFKRRTPGAMASYMVYPAEALVHKVSPDIPAQHAAFAEPLSCSLHAVERAQITFEDTVVVAGCGPIGLGMIAGAKAKSPMRVIALDMAPDKLKLAEKCGADLTINIAEQDAEKIIKDLTGGYGADVYIEGTGHTSAVPQGLNLLRKLGRYVEYGVFGSDVTVDWSIISDDKELDVLGAHLGPYCWPAAIKMIESGALPMDEICTHQFPLTEFQKGLDLVASGKESVKVSLIPA
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MAGFTLGGGTAPTGGFSFGTTTNEPANSSGNMTSTIFGGNGGTTRPSPTDTSNAPKQQMASAIAWDPTGTVALSICPSHKNNNTPSSSNEKEAMNLDVFLSHDGTGCPDEETTCLLEYLDARDEWIASATNGQSISISDRNGAMARLSKDYRAALTRCIEKLEEKNQRDAVKEGEDDEVRMGEKEGDDGTNDNLELLDLTSSLSYLVEIFLLPSASSGGSRFKDPNTTTSKLDGPSGSLTADTVRYLRHHHANSNGLLDNFEVAEMLDSDQPEYYKFPASSTPPDLSGPYEYPYWNLLLHLVRRGDLEMAWHVLSHHSGCRHAEKEAMTDWGEEHSAEFEGFASIRSLLLSAPIPGGRGDGYCDNSGLLDHLDGDELEEEEEKRLAQGPGEQYDEDALGMEVEDINAPMMQGVPRNAYLLWEPAPRQGNRLRTLRYRGELRRCGQWDANAADESLDSLLLPEGYQPRAAQSSFQTWQDIVRQQFPNTGGIGSGDSSLSVLFRRFPQLEQILSTLLGVVHPHINNATCHWSEVLLSELLYSRPEIMPDDIAIRAKVAMSSCGELSGLDEIILSIMKGNAADVVTAMFTSLGGLSGAALPATVLSLLFNLLVEAGAISPVNDTSSSTKTEFLLNAAEAIVSSFSIQQQCDVGVRTAVRLLLPHAPPTRAPTTSNVSESVIGIMYEPRISAMISEVISHRLPDTDAEALTLIKLCEKAIQLGSVRIADACESLVFSRASFHGSNGNTTRQAYWLLRGMEIMSRWLPAECQRTLGFACRRHFDYLCEKSASDCVSLLATNTHIDEEARESREKDASVVLSAASTLLQTVLEDSSMSSVLRSHVEVNLLRCVVDISVADAKYDDVKMAAELVHCLEERTLKDGVVSTLATPSMYLELLQIAVTILDREEEKADEPMEFTKCAFTVHGIHILMARMTQIMSWTGALSSQSAQSSIHIPAIEAELLRSMRLILCKGLVRAFASSKATTQSAKHHSHVPNVISLEDEVDMMLSPSI
The following text describes a protein:
Function:
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTEVVDDAVVKVPCCICGVPTEPNPFNMCIDCLKQKVDFTDTVPNTSAVVYCKNCGRYQTGPTTWQHAELESPELLSICLSKVNGLKDMKIVDSQFLYTEPHSRRIRVSLTLQKEALNGTVLRQTVIVTFVVNIVQCPKCVEAATPREHWIANVQLRQNVRHKRSLFRLEQLILKHRAHAGTTSLERVDDGVDFHFPDKAGANRFINFLLQHSPAKYDETAKQVGEDIQNGTLDMRFSYPVKVPPVCRQDFVILPDFFVKKTGNQAHVAVVHRVTKIIRLVDPMTATPIDIDGPTYWKNQFDPVCTIDSVTKFNVLNIEPFGPRNGQFQLADVELADENYEEQIMVRTHLGDHLHIGEPCLAYDLRTLVLPDKVEDVIKKYDISKVIIVGRTHEKKHGIRKWKVKELAPHKSSDDEEFENFMDEMEDDKELRQDVDIYKNPDAEGKPENQLLETTIGLSEMKIDETGEQYSFTPEYLKH