lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on acyl CoAs with short chains (propanoyl-CoA and butanoyl-CoA), branched short chains (2-methylpropanoyl-CoA, 2-methylbutanoyl-CoA and 3-methylbutanoyl-CoA) and medium chains (octanoyl-CoA).
Subcellular Localization:
Mitochondrion.
Sequence:
MMTPIGIRIRKQIPLSYHYSSIQALLSRFTPTPYNPISNSSSSTQTIPTQFHESQCTNPISRPTVFLFDPPPIRFTHTKSFSTDPSSLDFPSNQPPVVSTISSHHNISQPIDAGSSIRKPISLWPGMFNSPVTNALWEARSNMFEKYGEPTADPPSQSELVTKSPAQSRTSILYNLSSDYALREHYRNPWNMIRIGKLLEDLDALAGTIAFKHCTNEDGMSRPLLLVTASVDKMVLKKPISIDTDLSIVGAVTWVGRSSMEIQLQVLQTTHESSDPSDSVSLVANFTFVARDSKTGKSAVINQISPETGEEKLLWREADERNKMRKMKRKIQKDLELEKQYIERLNALLAEGRVFCDLPALADRNSILMKDTCLENSFICQPQQRNIYGRIFGGFLMRRAVELAFSTTYSFAGVVTHFLEVDHVDFLRPVDVGDFLRLKSCVLYTELQNPTEPLINVEVVAHVTRPELRSSEVSNKFYFTFSVGPEAVKDGLLVRNVVPATEEEARRVLERMDAETPHPHSQYENEI
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (By similarity). Together with nlk.2, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with ube2k. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
Subcellular Localization:
Chromosome. Note=Recruited at DNA damage sites. Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers.
Domain:
The zinc finger domains (C2H2-type and C2HC-type zinc fingers) bind DNA and mediate recruitment to double-strand break sites. They show strong preference for DNA with 5'- or 3'-single-stranded overhangs, while they do not bind blunt-ended double-stranded DNA or poly(ADP-ribose) (PAR) polymers.
Sequence:
MAEAMSCSSEITEEFLCPVCQEILQTPVRTQTCRHVFCRKCFMLAMKSGGAYCPLCRGPVNKSERSAPVRATDIDLEMRMLSGGCMYCGKMMKLHYMKLHYKSCRKYQEEYGLSPKNVTIQTGQNSTKCQEPKYKCPLCSEHNLNQRSLLEHCNNVHYYEEVEMVCPICATLPWGDPIQTTGNVIAHLNARHQFNYQEFMNINIDEEAQFQIAVANSYKISR
The following text describes a protein:
Function:
General activator of RNA polymerase III transcription.
Subcellular Localization:
Nucleus.
Sequence:
MGCPNCGSTTFESDTASGNTYCTQCGVVVEQDAIVSEVTFGEASTGAAVVQGSLVSNDQTHARTFGGPYRNQGSVESRELTIANGRRRISALAIALKLNERHIEAAVRYFTLAINNNFIKGRRSQYVVASCLYIVCRISKTSHMLIDFSDILQINVFKLGSTFLKLCRVLRPNLPLLDPSLYISRFASLLEFGPETHRVANDAIRLVARMNRDWMQIGRRPAGICGACLLIAARMNNFRRSVREVVHVVKVADITIQKRLDEFKLTESGDLSIADFRNIWLEGQSDPPSFTKNQKFQQYGAQKVSNIDHTQEYMSPIKRTPDFDGNEVKSEELSQTVKVESQETPVHLKADEREIRKEVTETLKGDELRKISLQVNVKFSEEEVTLEDVDDDEIEDILLDKDEILTKTQVWMELNKDYLAEEEAKNLKLQEDLKKGIVRQPRKRRRYRPRDSTSDGIADTAAESAKEMMQQRAFSKKINYEALDMLFDEEQS
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MYRLSCESFKQRNLAHNGRRSDVEVMVKLFGWRIVWALKLSGIQFDFIDEDLSNKSPLLIRCNPVYNKISVVDGFKIIERERSPLLSAWMREFAEVPLIIKNRPPYEKLLAKFHAVRQASLVAALPK
The following text describes a protein:
Function:
ADM function is mediated by the CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes with ADM showing the highest potency for the CALCRL-RAMP2 complex.
Subcellular Localization:
Secreted.
Sequence:
MQLILQSIFCCCLLAAVAPGVDSAKHDLKRSVWLQRSKRDLSLPALRALENRQFVRPDDVKDNLRPHSSTDISIRAKRSKNSINQSRRSGCSLGTCTVHVLAHRLHDLNNKLKIGNAPVDKINPYGYGRRRRSVPEKVLRLRKDGSGMRMVWSSSNSQSWLHKLEALLRRT
The following text describes a protein:
Function:
Toxic component of a type I toxin-antitoxin (TA) system (Probable). When overexpressed kills cells within 2 minutes; causes collapse of the transmembrane potential and arrest of respiration.
Miscellaneous:
MISCELLANEOUS: Probably inactive in strain K12 MG1655 due to a genetic locus rearrangement, the locus for its antisense antitoxin RNA is missing.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE
The following text describes a protein:
Function:
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
Subcellular Localization:
Cytoplasm. Endomembrane system. Nucleus.
Sequence:
MDLLCCEGPRFRFAYKDPAILKDDRVLTNLLACEERYLPSCNYFKIVQTEVEPHMRKLVATWMLEVCEEERCEEEVFALSMNYLDRILSLLPVKKFQLQLLGAVCMFIASKMKETSPLTAEKLCIYTDNSITTEELLDWELLVLGKLKWDVSAVTPHDFLDQIFSRLPLDRSTLDVLRKHASTFIALCCTDDKFLLYTPSMLAAASVCAAFTGLGISSHVSSRSWTATHLASLLHAITNIEPECLRSCQDLMEEVLHLSVKADPTRGKEAHTPSTPSTPTDLQEIQF
The following text describes a protein:
Function:
Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.
Subcellular Localization:
Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell.
Sequence:
MGLPVSWAPPALWVLGCCALLLSLWALCTACRRPEDAVAPRKRARRQRARLQGSATAAEASLLRRTHLCSLSKSDTRLHELHRGPRSSRALRPASMDLLRPHWLEVSRDITGPQAAPSAFPHQELPRALPAAAATAGCAGLEATYSNVGLAALPGVSLAASPVVAEYARVQKRKGTHRSPQEPQQGKTEVTPAAQVDVLYSRVCKPKRRDPGPTTDPLDPKGQGAILALAGDLAYQTLPLRALDVDSGPLENVYESIRELGDPAGRSSTCGAGTPPASSCPSLGRGWRPLPASLP
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MLKKISEACGLSSVPLTKGDIKKYENIPRFTYRCNFQAIQPGNITSDSGWGCCYRSAQGLIASYFLNYAPVDAEYFFTVFNEIPMFSLFEDRVEMPFSIQNLVYRSELFGVKPGTWAKPSQLAATIESIFKDLKLSVLISKDSNIIPEDVKTMRAPFLLLIPILLGMKDVEQKFIPFIKYTFQRPEFLGAVSGSSDFSYFLVGLSEDQNVVYFDPHVTKQAVASSFDHSEFFEVPPRGIKMKSLNPSFLLGFFCSSTENAISLIEDITKLKDSPITFSEIRKDLVDQVLDIDDIDL
The following text describes a protein:
Function:
Probably mediates the nuclear export of actin and profilin-actin complexes.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MNNNDMDQKAKELQNVLEQFYLTTDNPKRKEIDTILNNYKAQSDSYEHVQYYLVHSDNQYVIWFSLSVIEDKVNKAWNSISASSQTQTKGLLLDIYLNKTGANSNSTVKNVLPQFIISKLGQVIADIGRYEFESNPQSYLLNITSIVRNPSTSIRGINLLQCISDSFTTNKKVISQQKKTTLKKLLHQNSPIIIQVLVDCLGQLFDQNAEKKFKHANLLAFHVGSPDTNTYTASFNAESKNLTKAVFDALLSYFTWVPLSDLLVPSLFDILFKYLRLDKNSIPALECLNEIVSKNLVPKGFESFLMRIFHQVYSLLTDIVSNGGQQINQYHPEFLNKFTQFIQIFINNHLGRIETNPNFPIPDFLGLLFQYSFFQTQPESFLQCIDIWSTFLDYLINLSQENGTPPPSKYTDGLLLFQSELVKRILYIFNNNTLSELDDEDKEINENGISETQLESYIKKSIEVVAKVTELYPEKSLENLYPLFTQNVTSFFCKAEESIKQGVSMENEQQFQYLVKDVTTILHLFGRLADQFVVSFAQTFTAANFIFQKLLDMCLFSVNQYIYKFGSDWEKLQIELLCTIRSFCFWLAEYGNQVRAIVGQQPDFDSNITKLISIIVPLFERNAPESILSSAGKLLMSLATISKPLNLFTQMDMLISNIHNICAPLSPSIQSILYPAISCTILLPPSNVNLSQQWDQRRPKYSPFIKGITASFLEIPQIPNFVEGKIFCKEELIQRVLRVLKVVTAIIRTVPEVTQAKSILHDGIQDTLKVTLGLFRVYISYPIVLEAILDFFFVLFEFLKAQVGVVFTQQTISTFLDILGGDNLNQLLSSGNDTGISIIKKLIEILTFIVQQPGNSFESLLGSTIEFSMEKLYPMIANTSSVLRSPFFTLLYSILDNHWKQCQQIQINSILTSFQSIFKQNDVNLFKQNLDHFEKLNSKLKLYEKISSMEPVFGCSFISMFFDVLISDTQSVHTDDIIVTIYRFASLNFDKFFNEFFTTFLVQKNQLSNEQKQILRSNFSNAIDQPTFSTNMTQFINDFSYFSFINS
The following text describes a protein:
Function:
Embryo-specific transcription factor required at the globular to heart stage transition in embryo development.
Miscellaneous:
MISCELLANEOUS: Plants lacking PEI1 produce white seeds in which embryo development does not progress through heart stage.
Subcellular Localization:
Nucleus.
Sequence:
MLKSASPMAFYDIGEQQYSTFGYILSKPGNAGAYEIDPSIPNIDDAIYGSDEFRMYAYKIKRCPRTRSHDWTECPYAHRGEKATRRDPRRYTYCAVACPAFRNGACHRGDSCEFAHGVFEYWLHPARYRTRACNAGNLCQRKVCFFAHAPEQLRQSEGKHRCRYAYRPVRARGGGNGDGVTMRMDDEGYDTSRSPVRSGKDDLDSNEEKVLLKCWSRMSIVDDHYEPSDLDLDLSHFDWISELVD
The following text describes a protein:
Function:
May be involved in intra-Golgi retrograde transport.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MEIVSRAWESVDWDRIQTRVEAEVTALGQRQDDSEIRKTRLVEESNAYRGRTNKDSRKVAIPLIKAFQSEFDGLLARSTAAENALIDICKSIVSLPDPKSLLKGAEAWKNDAEKTQKAVEEREELKRQLIKVNNELEDLRGKDVKVRKLKDKLAKLESEQDIFIENAVNEVEKKAEQELNDRLTELIAEKEKMKEQNEILEKNMDSLESKNKDIQRKLEIAKQTVEQKDGLENEQLSIAMKDLADAKHKIVFLEERVSQLENEAEKVNESKKAGNIEDIAALGSVLVQKDDVIQQLTNDIKRHEASHVEELAKWKLAVSAVEKKNKTLIGELNELKNQLESRNDYEAIKNELRLLREIEFGDSAEANAESIERLGETVETLDRLLAEKNRRLQNENASLRVANDGFKGRNEEQEAELTVLKEKSERNDRLIAQLEADLASAVQDIGIPERMGTNEMLKDAPAPTISDASLVPILTSQRNRLHERVTSLEEAISLEKTKQLSVQNEIERVREENIRLCERIRFLQSPGGQQQANVEAGLGNDFRNGNRNKKVSLHDKTTLNMGRAILATPKSRTVFFSYLLILHALIMLVLYKFAFDQSVVRDAETECEYKFHQHMLDNHKQ
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes; Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MDATIKQDLPPPGGYEKIQYARNPAKTFFRGGRLLAGFIILNGCTTYYYFNHIYPGILHRRVEKKGSHLATLPLLLAEQDRAFLKHCRALRDEEEKLMANVPGWEVGKWNGQPIYKTLDKDVFSNPILSEYYCHAPYMDFYKKAMEEAIQV
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MEKNQKEIEKELEELRKREKELEEKIQKLETIAKNSNLRVAELQREIDYLKERYRRDLEEQRKFCYEKFAYDLLEVMDNFERALEYGRQAQDVKSILLGIEMIYSEMKKIFEKYGIREIPVEGKEFDPYVAEAVEKVETDQYPPNTVVKVIRKGYYIHDKVLRPARVAVAVPPQEEEGEEIT
The following text describes a protein:
Function:
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDKLLTIDLSHVYGFDKEIIFKKYQKKVDQIHQDFLAHKLADGHMTGWYDQPDQNHQFLLKTINQIDKKFKSLKVTDIVYVGIGGSFTGIKTVLDFLKPKQRTGLKIHFVPDLSAFQAASVIKEIKNKSWALITTSKSGRTLEPALNFRIFRNLLNKRYGNKHYQRVVVITDEKKGLLTKMASNHGYQKLVIDSNIGGRFSTLSPAGLLLAKLFGHDPKAILKGTLQAKKDLQTTSLENNSAYLYAVVRHWLYTTKKFKIEVCIAYHSLYEYLLLQHRQLFGESEGKNDKSLFPTFSIFTVDLHSMGQLYQEGEKVFFETVIDVKNPLVNINLPPSDFDNDDELDFLLDKSLNEISDVAIDSVIKAHYQANVSIIKLTLKEQSAFMFGYFYFWLSVATVMSGSLLGHNVFNQPGVEVYKKLMFEKLRSGH
The following text describes a protein:
Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MKKHKKTPCKRKYRQRAHCNPLSDSYIKYPRNYTYVDWSLHFPLYFEKNQIKDEYITNKENSKDEHIVTDNMKNNVENDNMNNVLYLNTNKYPVNYKMRNIFNESYENNKNVTILDIGCGYGGLLFSLSKIFNDKLILGLEIRDKITNYVGEKILSYRYNYHPYYQNISVIRTNVIKFLPNYIKKNQIEKIFFCFPDPHFKRHNWRRRIITIENLSLYYHLLKNNGYIYFITDVYTLYLWVIFCFSKCPYFKVLTNKDCENDICVKLIHESSEESKKVKKNKQNMYYCVAQKI
The following text describes a protein:
Function:
Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Regulates nucleoporin npp-5 localization to the nuclear membrane during interphase and to kinetochores during metaphase. Has a role in P granule integrity; may promote the 'liquid phase' of P granules by increasing the number of interacting RNA-protein complexes. Binds nos-2 mRNA, probably indirectly, and promotes its accumulation in P granules.
Subcellular Localization:
[Nuclear pore complex protein Nup98]: Cytoplasmic granule. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=P granule localization dependent on nucleoporins npp-7, npp-8 and npp-9 which are involved in P granule integrity; [Nuclear pore complex protein Nup96]: Nucleus, nuclear pore complex. Nucleus envelope. Chromosome. Note=Requires mel-28 for chromatin association during early steps of nuclear pore complex assembly.
Sequence:
MFGQNKSFGSSSFGGGSSGSGLFGQNNQNNQNKGLFGQPANNSGTTGLFGAAQNKPAGSIFGAASNTSSIFGSPQQPQNNQSSLFGGGQNNANRSIFGSTSSAAPASSSLFGNNANNTGTSSIFGSNNNAPSGGGLFGASTVSGTTVKFEPPISSDTMMRNGTTQTISTKHMCISAMSKYDGKSIEELRVEDYIANRKAPGTGTTSTGGGLFGASNTTNQAGSSGLFGSSNAQQKTSLFGGASTSSPFGGNTSTANTGSSLFGNNNANTSAASGSLFGAKPAGSSLFGSTATTGASTFGQTTGSSLFGNQQPQTNTGGSLFGNTQNQNQSGSLFGNTGTTGTGLFGQAQQQPQQQSSGFSFGGAPAATNAFGQPAAANTGGSLFGNTSTANTGSSLFGAKPATSTGFTFGATQPTTTNAFGSTNTGGGLFGNNAAKPGGLFGNTTNTGTGGGLFGSQPQASSGGLFGSNTQATQPLNTGFGNLAQPQIVMQQQVAPVPVIGVTADVLQMQANMKSLKSQLTNAPYGDSPLLKYNANPEIDGKSSPASTQRQLRFLAAKKGALSSSSDAQDSSFIIPPISKVMSDLSPAVTRSADVTKDLNYTSKEAPPSLARGLRNSTFNPNMSLTNRSVHESSALDKTIDSALDASMNGTSNRLGVRGSVRRSNLKQLDMSLLADSSRVGRESRVADPDALPRISESERRQDVVTSTPAVDPVQAVIQRHNDRNRDPPSLNLDTTCDEHTGLEPVSAATSSAASVVSTPSEETVNVNSAAGVKLTKPDYFSLPTINEMKNMIKNGRVVLEDGLTVGRSSYGSVYWPGRVELKDVALDEIVVFRHREVTVYPNEEEKAPEGQELNRPAEVTLERVWYTDKKTKKEVRDVVKLSEIGWREHLERQTIRMGAAFKDFRAETGSWVFRVDHFSKYGLADDDEPMDGSPPQQALQASSPLQVIDMNTSARDVNNQVQRKKVHKATDAHHQEIILERVPAPAALGDVVPIIRRVNRKGLGGGTLDDSREESCIGNMTTEFNESGHDSIIEEGQQPEKKPKLELLADLEYESSRFIRNLQELKVMPKANDPAHRFHGGGHSAKMIGYGKSKLIDIGIVKGRSSHVGWSETGCLVWSAQPRHNQVLFGTIDRTSDVNENTLISMLDVNVHVSETSRKGPSSQSNSVKSSLTSNFVTYSDSYSSMFAKYIDVAQAGGYDGHVSVWKLISALFPYERREGWSFERGEEIGEWLRTEAVKSVPDDRSADTSSNGVWNQLCLGDIDKAFQIAIDNNQPQLATMLQTSAVCPEATVHCFKAQLDNWKKCETLHLIPKETLKCYVLMSGLSHYEWDQDGKNHSINCLDGLNWIQALGLHVWYLRAWTGLEESYDAYQKDVNAGRAASNRGDLPGELIKLACESQHSVEVVLDCAAGENPNDYFLQWHVWSLLYSVGYRTMSKTSETRLHRNYSSQLEASSLSKYALFVLQHIDDDEERSTAVRSLLDRIARFTDNDMFDSISEQFDIPSEWIADAQFSIAKSVDDSTQLFELAVAAKNYLEICRLFVDDIAPTAVVAGDHDALKAACAMVRPFENQIPEWGATGMVYTDYCRLINLIENDAEEELLQDVLESLETRLHAPTISKNSLQKLSLQTIGRVLFEYRADKNTLPEWTKLLGHRQMFKIFRDRSSWGIERFTIEFD
The following text describes a protein:
Function:
Acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.
Subcellular Localization:
Nucleus.
Sequence:
MDQGGRSSGSGGGGAEQGKYRGVRRRPWGKYAAEIRDSRKHGERVWLGTFDTAEDAARAYDRAAYSMRGKAAILNFPHEYNMGTGSSSTAANSSSSSQQVFEFEYLDDSVLDELLEYGENYNKTHNINMGKRQ
The following text describes a protein:
Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MDTLKDQFVVPGDVIGKIGDLKVRIGPGLLQTKDTVLATKAGVLRYSKFHRFYWIENEQKRYVPQVEDMVIGTIIEKHAESFKVDIGSSCSALLSAYSFEGATKSNKPLLNVGNLIYCRVTVANRDMEPEVVCLSQKQKAEGFGQLIGGYMLNCSLGLSHYLLSEDCFLLQILGKHIPYEIAVGVNGRVWINSGSNHNTIVVSNTIYNSQYIQDDQIEPFILKSLSINETSGLVEQN
The following text describes a protein:
Function:
Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.
Sequence:
SAPSEGHRAHTARVARRRAGPGRRRRSGSRRAARRSRRAARRAEPATQRAARSAERRCRGVRLLCRRLEATRRGRHGSVFQLLTDLKEQRKESGKNKHSSGQQNLNTITYETLKYISKTPCRHQSPEIVREFLTAMKSHKLTKAEKLQLLNHRPMTAVEIQLMVEESEERLTEEQIEALLHTVTSILPAGPEAEQKKNTNDDMTMDEENPA
The following text describes a protein:
Function:
Involved in resistance to abiotic stress.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Cytoplasm.
Sequence:
MQDMRDQNPPQGYPAAEQVSEQPGQDKKKKKPRFFETKQKGDRGFIEGCLFALCCCWICEMCF
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGTRILDLLQLQNLTKRDPSAYKEEFLLQYQHYLTQLQIFQLKPTKEFKHFSQLVSYLSHVCVCYPKELSEFPKQISDLLENNCNNLEPELRRILAKSLILMRNRNLLPQIQMLSLFFKLFRVHDKPLRSLLYSHIVADIKNTNLKQKNQKLNRTLQNFMFTMMNDDSEIASKMSLKVMIELFRKKIWHDTKTVNVISNGVFSKNSKILITTLNFFLHIDNPDKPDEEEEDEAVKEKRAKDNFRKKSLAHRVGKKTKGRITRLAKSKVDLKKAKQEEDNKLQPNFPAIELIHDPQGYCDKLFNVLVKTTEKFETRIMIMNFISRLIYVHKLMVYNFYPFLQKYLQPHQKNITYLLAVLAQSCHELVDPDVLKPLVMTIAKYFVNDGCGSDVIAIGLNTIRSICSRCPLAIDTVLLADLIQYREKKEKGVAMASKSLLQFFKDNYPSMLPKKERGKNKTDIGLLAFGHQKVSQGIDGLDLLMDEELNARLDAIEAGEEFESDDDSDSDSDDEGWEDVNTTTADDDNNSEWVSDDDDEEGEEDEEVEDEEDEEEVDEEELEDDEEGDWESGEEIEGDDDDDEEWEEVEEEVEEEEEEEIKPTKKKSQQKEKVEVLRTDDIKVLTDEELIRIRKLRILKEARENNKQYEDMDQDDDENGENVHGLIRPEDLQGAHKKKKEEKLERIARAKEGRDGGYGSKASRRDKTGKSTTNEYKAKVTKPFVLTLKTKKVRGKSLKSFRDKQIGQREHSARQKRGRH
The following text describes a protein:
Function:
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MRFHFLTMLIGHWQIQQSREIIDAKKNVKMAPPISRSNYQSSILKSAFPEVSNIKVDPNSQLITMTLFKAQHFSKNIEQLSTFLQGFRQYLHYHIHASKTYLHSRIIKRISQFQRSLQLCQFEPEVEKKTEDLFASSGVKA
The following text describes a protein:
Function:
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
Subcellular Localization:
Nucleus.
Sequence:
MASKFPSLPAPRFAPPKPSPLSQPATTAPPEPPKSQPQPSANAPSSSAPPKKKKKKNAQPTAPPVVEDLGPGRQFATQVFKLVDTLKRTNGPMNLSDLEAQTGVRGLLSEHTDVPFNKELFDAFNSHERVNVTEKGLVRLWSYKPDYVINNPKQVLELLERFSGMGGMPVNTLKQSWPNVMTAITELENEGKVLVLRTESVGAKEGTPKTVFYDQLGCRENLGPTRGALDDEFREMWHSLQTPPVHSLPSELQEAGLTSSTSANLKPQQTTRKPKKKGGKGGKVKITNTHLKDLGIDLSKDYVPYKK
The following text describes a protein:
Function:
As accessory component of the DNA polymerase gamma complex is involved in the replication of mitochondrial DNA. Does not bind DNA. Essential for mitochondrial DNA maintenance and larval development.
Subcellular Localization:
Mitochondrion.
Sequence:
MSRIQRCFKSLASAGFFRTVEDNKLELLSHGREYAKLLQQHWTRLRPLAAHLGATKEPINPVNIQRFSFPQSQQFRNNFQKLVKDHPRKAKCPTLLKHQSTCSGPTSNSLFGIKGPTLHLTTDFLVEPHRALEHFYNMQRESKIWWMRLSSNPSRYRIVPCDLAEDLNPNDYQAIDIRTSYGDAGEVTVEQLSLVRIVDDKDFRLPDARTGEIVQPTVIRSVIELETTTCALLLDGCDHGRDSQSLLLHRVLAPYQCGIACVESDSELSADLSDLCQHLKHVLNHAGLRLSEGDGIRTTKNASHLAEHLLETDMLGIPYTLVINEQTLRNGLMQLRSRDTRLAETIHISDVPDYLLNIFKN
The following text describes a protein:
Function:
Component of the cell wall involved in virulence which plays a role in the relationship between C.albicans and the host.
Subcellular Localization:
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKYFTIATVLTLASSALAAIRDVQLFAQSSNEEINNLGLISRREGAGVNYLFLASGAETLKFDDETFTIFSELQTGSTTARQSLVVSGGVVQLSVSGQPLHVEIAEDGSVKFAGSDSVAAAKNINDPYNYSKDSFAVVTNGGEGSIPFKIIAKFIGGGKSSSVTKHTEAPTTSPVYSNKTVTVFTTYCPESTTITLTICSEVCTPTVIETSGSVTVSSVLPSSSTEAPPKTSVAAPSTTAEAQTTAPVTSYEGGANEIVGGGSMAIALAAAAIGLVI
The following text describes a protein:
Function:
Binds to dsDNA in a sequence-specific manner. Also binds a DNA/RNA duplex when the recognized sequence is in the DNA strand. Each tandem core repeat recognizes a single nucleotide in the target DNA via its base-specifying residue (BSR, residue 13 of each repeat); altering this amino acid changes sequence specificity.
Domain:
The protein is composed of 20 tandem core repeats (the BuD domain) with 1 base-specifying residue (BSR, residue 13), which recognizes 1 base pair in the target DNA.
Sequence:
MSTAFVDQDKQMANRLNLSPLERSKIEKQYGGATTLAFISNKQNELAQILSRADILKIASYDCAAHALQAVLDCGPMLGKRGFSQSDIVKIAGNIGGAQALQAVLDLESMLGKRGFSRDDIAKMAGNIGGAQTLQAVLDLESAFRERGFSQADIVKIAGNNGGAQALYSVLDVEPTLGKRGFSRADIVKIAGNTGGAQALHTVLDLEPALGKRGFSRIDIVKIAANNGGAQALHAVLDLGPTLRECGFSQATIAKIAGNIGGAQALQMVLDLGPALGKRGFSQATIAKIAGNIGGAQALQTVLDLEPALCERGFSQATIAKMAGNNGGAQALQTVLDLEPALRKRDFRQADIIKIAGNDGGAQALQAVIEHGPTLRQHGFNLADIVKMAGNIGGAQALQAVLDLKPVLDEHGFSQPDIVKMAGNIGGAQALQAVLSLGPALRERGFSQPDIVKIAGNTGGAQALQAVLDLELTLVEHGFSQPDIVRITGNRGGAQALQAVLALELTLRERGFSQPDIVKIAGNSGGAQALQAVLDLELTFRERGFSQADIVKIAGNDGGTQALHAVLDLERMLGERGFSRADIVNVAGNNGGAQALKAVLEHEATLNERGFSRADIVKIAGNGGGAQALKAVLEHEATLDERGFSRADIVRIAGNGGGAQALKAVLEHGPTLNERGFNLTDIVEMAANSGGAQALKAVLEHGPTLRQRGLSLIDIVEIASNGGAQALKAVLKYGPVLMQAGRSNEEIVHVAARRGGAGRIRKMVAPLLERQ
The following text describes a protein:
Function:
Mg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol. May play a role in vesicular trafficking through its PAP activity at cortical actin patches. Can also utilize diacylglycerol pyrophosphate and lyso-PA as substrates with specificity constants 4- and 7-fold lower, respectively, when compared with PA.
Miscellaneous:
MISCELLANEOUS: Present with 2289 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, actin patch.
Domain:
Contains one Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity.
Sequence:
MNSQGYDESSSSTAATSGPTSGDPRMGKKQRFMNLIRTTKDVYIPNLTSSISQKTMDGIRSTTNSFEGYNDLPMELPHNTTITYFPTYTTTNLVDPDGLSAPRKDFETTVRCAVSYPGNPTSRRNRWLLSLCKQYLRTGTAEADVAPVVPPHLEEDSGDLNDSQSSIESSLSSKSENRYSHMGIQEEDVLNERIQGFLSKKVPNTPVVVDLLPKDKLRGDTASFFGTTDSYGNLLIKAETDFLPSKINITLDTPIEGHADPISETFPANYVSPYGIGLISDIDDTIKHTGVTGDRRSMFRNVFIHDVQSWVIDGVPLWYKTLHDVADVDFFYVSNSPIQTFTLLKQYICANFPPGPIFLKQYSGNFFSTIMTSSANRKIQPIANILKDFPKKKFILVGDSGEHDLEAYTTTALQFPNQILAIYIRCCSNSMSDVPSHDEEVMNEVNNIIELQQRPMQMTKSTVRTRRRPPPPPIPSTQKPSLTEEQTESIRMSRRNKDENNAKRVAPPPLPNRQLPNLDANTYYVPSSQNDYGMYGAFMDKKADEWKRRVMDSIQKLSNQDTTLMFFSDPALSLEDSIRRIREKYSN