lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Co-chaperone required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Stimulates the ATPase activity of its specialized Hsp70 chaperone partner SSQ1, to mediate the transfer of iron-sulfur clusters from ISU1 to GRX5. Binds to the substrate protein ISU1 and targets it to SSQ1.
Miscellaneous:
MISCELLANEOUS: Present with 2010 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLKYLVQRRFTSTFYELFPKTFPKKLPIWTIDQSRLRKEYRQLQAQHHPDMAQQGSEQSSTLNQAYHTLKDPLRRSQYMLKLLRNIDLTQEQTSNEVTTSDPQLLLKVLDIHDELSQMDDEAGVKLLEKQNKERIQDIEAQLGQCYNDKDYAAAVKLTVELKYWYNLAKAFKDWAPGKQLEMNH
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Sequence:
MKSIIYEDLLVDKSSVHQELFCIICSNLIKDARQCSESHIFCDSCIKEWLKTQTTCPSCRNFIFYDNLAKNRLVNNLIGNLKIHCPDGCCETITIDELESHLKCCEKRYVKCPQGNCGNIRLSSLDEHLNNCRYNYINNCLYRNGNQERQIIQEIKEERKKIKELQMCNQSEFKESEFFDLSKENTYHYDVFNKDYLNYLQNKVNEIQIVDSEHIQNKKQEIACNQIVGSVQDDNVNHALDWIIQNYNEKIRNMGENGYFEIIPFEHIILRFYPLRTEYFTTPCKPGVTPMEIWQIQIISKCLIPIDFNLTIQSPISREVKSILRENVSLDIKFDRVAVKNDLKLSFIINYKKKYLSLFTS
The following text describes a protein:
Function:
Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTSLPPSSQDNAAAIETSQLIVAPTTAPLATTENDAAASEPSVDPPSPAPFKRGHASKPSVGIAASLFGSGGDEDPFSAISASNGPSSLTQLTEVKEEPDLFGSFDASNPHSHLNDATSAVDPVSSLFGTDSATSVPIQSPAAAASAASTTDGLTVPTIDGNASAPASGPASPGALFADLSYQDDWLASTTDQNAQHPAADVHGENTTIHQADPFGAADGGQGSLSWLNQQESHASVDPATESQLDAYGRPIVAYEGDDQQEQYPQDYGYHDQQGYGYDKHHGYNYSRPQASYDQPEGHDYHQQGYGSQEYGQQQVYDYQENGYDQQTYDQPQTYDQQNYHQQGFDQHTYAQQDYSQSGYEQRAYDQHDANQYNYEQFSYQDQNYTVHATTEPYAATSSANDAIDVAEQSYNTDAYADYPAHQANAHSSAGYEGYAAGPNNGYDAATSGRAYDAAATIDQSTQDQYSTDPHSAYESQGYTQQPSVADSYTQQQQSRSYDPYAPPMQAQQQAHSHQSYSHSADSVPPSTFGYDAGAYGDVQGVSASRNQQGFVRAPSPYDPPAATASPAAPLSATANDNSLPPPPMGPPQGPPRGPPRGPSRSASRNMAGSTSSASLDAPPLPKRTSSAVSLEDESQQEPTPTWPNGTETPQKQSQPLLGSTDTPPTTYTRPSSAWVDSLEQAAATPPTFSSGDDSLPKLTITDESKHAYSNIGEAPEIETSMREVEQQLSDKKLSTAVDDATIAFDHLNLDQSQQMYAGRSSQYENGYSEEDTSTPQPSDQNADGYGADYGTEQNGQFDAEGGHRYDQFQSTQQSSDWNSWNEEGASQAPTTIEHNPYAPSDPQQQQEILTAPTQSGEAYSDLAYGPEQSKLIEDPYDPSPQAHDPPRLYTLTGQDDSEAKTPLAAHDEQDNWLGSASPALGNDAAQDPYSSVSGSTFVTGAQNGAAPHSGYDPYGPPSVNDRSIDTYGAHDGHARVQPEPAASVEDAYTETDQLHEQSNQATYFDSNKRAGSPQQYGYGHVYGASDSAYAPLDQYDSSAAGTGQGPRSAASDTRSQSASETSADMLQAMRSATIPIASFGIGGKLVSYFPTSRASTGAEGADGAGGSSNVYGSYSYNTSSYPTQLKIQSLSSLVSSTAYASAFDPLTFPGPVYEGPSGTNALSRATGAASASKTKKAAVLKHLEERIQELSAGVGYLRRRPSFSASSTGSNRGTQAAQDQDGELEARRTEDKVLLLRLLRLLVENDGQTSSNAFEQGVRSLIIAPDTQDVSSSRGFAMSVTSTTPDDGAEGSVVTSHELRTSFLQKVQGMLLCGERKEAVDYAVAQRMWAHAMTIASCVDKECWKEVVSEFIEHEVGAAEASLAALGQGDLQGLKVAYNVFSGQDPVSIFDLFRTKTQLGQMGGLQPAQVESTTTPSALPSWKESAAIVASNRSASDSAALTAIGDGLCTRGLLEAAHFCYLLSPQTSPIGGADTSGARFTLLGLSSPKASAAFVQDLDGILMTEVLEFAQGLVPAVKGQEPFPGIAHLQAYKLVHAQHLADLGEVSKAQRYCEAIAQCLKQSKASPYLHSTLLSQSKQLSDRLVGAPQTGPGGNWVTRKMQRPTLDGVWGALEGRFTKFIAGEEGAMDADSPNKNSKGSVSSSIGPFSHYSAITPDAASGGMTRQPSFNELRTGSPSVPTSRSGSAMDFRNATKRAASPKHRASTALSMRPLNSDPYSDWPQPRAPGNGTGSEAASNYDRDSVRSSSEMPRGAYGYGASLHTGPAQVYGHGAQVSAFSTASSTYGGPAETSFASNAAPWNGSAGQGTRDTDSSRRPSADAEALGAGSESAYGGYGDCGGYGGSSYGGYGGTYGEATQTGGTDGEVGDDAGGSSATGHANTPFYGYDPHGAQKPQFVSNVNAGDALEGGGQGGFVSPFDALSSISQTPQPPSQGNQYTSSYSRHHADVNEEEDDDDLGLGNSSGRRKASNADGTSFEAGDASPRDSVASSSAAHHAAKQNESEGKKDDTASNASGSDEKRQELKPSASWFGRLWGRSPSTDSAAQQAQAKAKKAHLGEETSFVYDKELKRWVNKKAGDSGSASSTPPPPPPRTQSASPASQPDRSTGASSAPPMRGPPSGTLTMGRATPPISEGNEEGSSGLAPSRGPPGMGSLSRARSNLADHSMPPASQPPMGSAAGPVRGSGASTPAGGVSGPPPPPGGSRMGTVKKRPIKSRYVVVD
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MARAMALSLLLLVACFNLASAADSLTVVRADRKVDLLTQVVRVSTAWKVQNNGAEPVREVKLALTSEQAERVAFMEVVIKETKGKGKNAAVGLLLPVIRYSQEGSVIVYTLALPREIKEGEIATFESYVALTHQLKPFPEEITQSDSQLVKYHDTAYILSPYPVKVQTTMFKLSSSRLESFTKVNPTKVADTEVRYGPYEDVEALERKPITLHFENNQPFAVVEELVREIEISHWGNVYITENYNKLAHQGARLKGGFSRFEYQARPGASGVSAFRHLLAKLPVHANSVYYRDEIGNISTSHLRSDFRRTELELEPRYPLFGGWKVPFTLGYSVPLQDLVFKAADGSRYLNISFGSPFGNIVVDKLILKVVLPEGSYDVSATVPFPEGSFEQRQEKKFSYLDTVGRTVHVIVKKNSVMEHQFKNVLVHYRFNPLGMLVEPLMLVLAFFAFFASCIAYTHFDFTLSKSTSAYLAQVQRDQVIDVISKLQKVLGIRQTAEERLEASLKDVLRTGDITACKADRKNADAVWKSTSKDLKALLDTLQSTMKTVPGKPSTTKPSVIVTKVETLLLKEKEMVEKLQQKQTFIVDAYERKLSGKEIDARIAPVQEKLESLRQEVSNLRSSLED
The following text describes a protein:
Function:
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation. Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites. May also serve as a sensor of DNA replication progression.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSKTFLRPKVSSTKVTDWVDPSFDDFLECGGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQGGSILLITGPPGCGKTTTLKILSKEHGIQVQEWINPVLPDFQKDDFKGMFNTESSFHMFPYQSQIAVFEEFLLRATKYNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLRKYVRIGRCPLIFIISDSLSGDNNQRLLFPKEIQEECSISNISFNPVAPTIMMKFLNRIVTIEANKNGGKITVPDKTSLELLCQGCSGDIRSAINSLQFSSSKGENNLRPTKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFLFRALGKILYCKRASLTELDSPQLPSHLSEYERDTLLVEPEEVVEMSHMPGDLFNLYLHQNYIDFFMEIDDIVRASEFLSFADILSGDWNTRSLLREYSTSIATRGVMHSNKARGYAHCQGGGSSFRPLHKPQWFLINKKYRENCLAAKALFPDFCLPALCLQTQLLPYLALLTIPMRNQAQISFIQDIGRLPLKRHFGRLKMEALTDREHGMIDPGSGDEAQLNGGHSAEESLGEPTQATAPETWSLPLSQNSASELPASQPQPFSAQGDMEENIIIEDYESDGT
The following text describes a protein:
Function:
An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
Subcellular Localization:
Cytoplasm.
Sequence:
MEKEMDEDTLLKKLRWRCRRGMRELDQLFGRYLDRRWAQAPAAERAVFLQLLDCEDDKLWRWFMGYEACPDADNAALIADIRAMPA
The following text describes a protein:
Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MIIPIRCFTCGKPLGHLYAVFKRRVLAGEHPGRVLDDLGVTRYCCRRTLMAHVEWIDDVLLYERRS
The following text describes a protein:
Function:
Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.
Sequence:
MGEIPSLVKIAVSLKIQPNDGPVYFKVDGQRFGQNRTIKLLTGAKYKIDVVLKPGAVRATTINLGGVIIPLEEKSRDPQQACYTAFYDTEGVAHTKSGERQPLQVIIQFEEIGSFETVWQVKFYNYHKRDHCQWGNSFSCIEYECKPNETRSLMWINKEMFH
The following text describes a protein:
Function:
Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody.
Sequence:
MEVRCGGLLFSSKFDSGNLARVEKVEKPGAEGDAFSGSVSGGSVPTPDYEFNIWTKPDCAETEYENGNRSWFYFSVRFGAPGKLIKINIMNMNKQSKLYSQGMAPFVRTVPIRSRWERIRDRPTFEMVENQFILSFVHRFLDCRGSTTYFAFCFPFSYEESQELMAGLDDRFSDCKNITPGSFPDSIYYHRELLCHSLDGLRVDLLTISSCHGMTEEREPRLDKLFPDRSTPRPYRFTGKRVYFLSSRVHPGETPSSFVFNGFLEFILRQDDPRAQMLRRMFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLNPDFELHPSVYAAKTVLLYHHVYNSVGPNDPDWRTSVSLQTSNISLCPKTSNHSLKDLPLEDSLSELEKANNLLNSMEKEECYITCPQAVTQGAPPENDPNFLSDSRDFIRQRDVFILESDTEPKDIYSHSGSSQPTIFTKSIPPQESGIAFYVDLHGHASKRGCFMYGNYFTEENDQVENMLYPKLISLNSANFDFLACNFSEKNMYAKDKRDGQSKEGSGRVAIHKATGIIHSYTLECNYNTGRCVNSIPAACHDCGRASPPPPPAFPPKYTTQVFEQIGRAVATAALDMAECNPWPRLIMSEYNNLTNLRAWMLKHLRNTKGVLPGTLKKKSTKSPVKASSLTSGSLSENSLIRTRSYSNSTASTNSQQNSPQIKPSINFTFLCSSSNHSPPKVSQRVLGPVRETKAQEKRRQQSLLRSSVRSPTACQQRLSTQAPSLSSGYPKTSSHAKTSCPLSLSLSMSGSGFSGLSQAAKVKNGTKKNNLEGDSTRQHIHQGHGIALLQNMQKRGSSHNNAEYSKSLESLGVRPSRIPVRRNGLLTNEKESPILRVWKYTTDTSLKHCSLADLAAVTSSLTVCSVPLLKSKAEEPVFICEATKETADQHFPAVSQDAAHLSAYQSVLSFCSEA
The following text describes a protein:
Function:
May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways.
Subcellular Localization:
Secreted. Cell envelope. Cell surface. Note=Secreted via the ESX-3 / type VII secretion system (T7SS). Secretion is dependent on EsxG and EsxH.
Sequence:
MTLRVVPESLAGASAAIEAVTARLAAAHAAAAPFIAAVIPPGSDSVSVCNAVEFSVHGSQHVAMAAQGVEELGRSGVGVAESGASYAARDALAAASYLSGGL
The following text describes a protein:
Function:
Oxidizes the CoA-esters of 2-methyl-branched fatty acids.
Subcellular Localization:
Peroxisome.
Sequence:
MKSISNLEKANSLLPDLPKGPLCAYRKKASFNWKEMALFIEGEDLISFKNEIFSTLENDPLFARLAGEELSLEKYRELTFLRCRRLFEYDFLRLEEFVEKPLKLVALITSLGMYDWSLGAKYLLNTQVFKGAVESGGFDRHADVINQNGTMENFGCFALTELSHGSNTKNMRTTARYDSSTQEFIIHSPDFEAAKFWVGNMGKNATHAVVFAQLYTPDGQCHGLHSFIVQIRDPKTLLAMPGVLVGDIGRKLGQNGLDNGFAMFHQVRIPKENLLNKTGDITAAGTYTSTFKDRKQRLGASLGSLSNGRVMIISMSLVNLKLAVSIAIRFSATRRQFGLTDDEEIPVLEYQMQQWRLLPYLAAAYVLDHFSKTLFINSMEFTIGLLMGDKSPQQAELGREIHALSTSGKPLASWLAQQGTQECREACGGHGYLAVNRLGDIRNDNDPNCTYEGDNNVILQQTSNYLLGWMNGRQQDKGPIASPLGSVNFLEDYDRILCQKFIVSDVQDCMDPSVPLRAFKWLVCYLLRESIQKLRNLEKAGYSEFEARNQSQVFHCRSLAIAFIEHVVLQRYYDYVHSSKTPASLQPVLKQICSLYGLWSLNKHMAVLYQGGYVSGENAGRFVQDAILELCSKLKQEAVALVDVIAPPDFILNSPIGKVDGELYKNLWSSVLQGKKVLERPSWWLEFCNNKPVVGQLRSRM
The following text describes a protein:
Function:
May play a role in specifying the identity of particular somatic muscles and neurons of the CNS.
Subcellular Localization:
Nucleus.
Sequence:
MVMLQSPAQKASDSASAQNTAVGGLMSPNSNPDSPKSNTSPDVASADSVVSGTGGGSTPPAAKIPKFIISANGAAVAGKQEQELRYSLERLKQMSSESGSLLSRLSPLQEDSQDKEKPNHNNNNSLTNHNANSNTRRSQSPPASVGSVSFSSPAQQRKLLELNAVRHLARPEPLQHPHAALLQQHPHLLQNPQFLAAAQQHMHHHQHQHHQHPAHPHSHQHPHPHPHPHPHPHPSAVFHLRAPSSSSTAPPSPATSPLSPPTSPAMHSDQQMSPPIAPPQNPPHSSQPPQQQQVAAPSDMDLERIKLVAAVAARTTQASSTSALASASNSVSNASISISNSSSGSPSGRDLSDYGFRIQLGGLAAAAAAAAATSRQIAAATYARSDTSEELNVDGNDEDSNDGSHSTPSVCPVDLTRSVNSSAAANPSSASTSASSDRDAATKRLAFSVENILDPNKFTGNKLPSGPFGHPRQWSYERDEEMQERLDDDQSEDMSAQDLNDMDQDDMCDDGSDIDDPSSETDSKKGGSRNGDGKSGGGGGGGSKPRRARTAFTYEQLVSLENKFKTTRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGMDVNSPTIPPPGGGSFGPGAYASGLLYSHAVPYPPYGPYFHPLGAHHLSHSHS
The following text describes a protein:
Function:
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MDLDALWKRTVENLVREGIIKSEAVRRAFLKYPRYLFVEDRYKKYAHVDEPLPIPSGQTISAPHMVAIMLELADLKPGMNVLEIGTGSGWNAALISELVKTDVYTIERIPELVEFARRNLERAGVKNVHVILGDGTKGFPPKAPYDRIIVTAGAPDIPRPLVEQLKQGGS
The following text describes a protein:
Function:
Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEPLAPMRLYTLSKRHFVLVFVVFFICFGLTIFVGIRGPKVIQTSAANFSLNNSKKLKPIQILSNPLSTYNQQLWLTCVVELDQSKETSIKTSFPMTVKVDGVAQDGTTMYIHNKVHNRTRTLTCAGKCAEIIVAHLGYLNYTQYTVIVGFEHLKLPIKGMNFTWKTYNPAFSRLEIWFRFFFVVLTFIVTCLFAHSLRKFSMRDWGIEQKWMSVLLPLLLLYNDPFFPLSFLVNSWLPGMLDDLFQSMFLCALLLFWLCVYHGIRVQGERKCLTFYLPKFFIVGLLWLASVTLGIWQTVNELHDPMYQYRVDTGNFQGMKVFFMVVAAVYILYLLFLIVRACSELRHMPYVDLRLKFLTALTFVVLVISIAILYLRFGAQVLQDNFVAELSTHYQNSAEFLSFYGLLNFYLYTLAFVYSPSKNALYESQLKDNPAFSMLNDSDDDVIYGSDYEEMPLQNGQAIRAKYKEESDSD
The following text describes a protein:
Function:
Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.
Subcellular Localization:
Secreted.
Sequence:
MVNVLHVWLLLTIAALAASSDFLPRHTNYHSNATLPLSKCPGYKASNVRTTASSLSADLILAGPACNTYGTDLKKLTLKVVYETDDRIHVVIQDPANVVYQVPESVFPRPAESTVNSKDANIKFHHVNSPFSFSITRAKTGEVFFDTSAASLVFESQYLRLRTKLPPNPNLYGLGEHSDSFRLNTTDYIRTLWSRDAYGTPAGTNLYGNHPVYFEHRAGGTHGVFFMNSNGMDIMINNTNGRNQYLEYNTLGGVLDFYFLAGPDPIVLSQQYAELVFTLDSERFPLDMMQDINHYLHDHDQKQILMVDPAVAYQNNPAYQRGAADDIFLKRDNGSFWLGVVWPGVTVFPDWFSKGVKNYWNNEFSIFFNPINGVDVDGLWIDMNEPSNFPCYFPCDNPYASAVGYPPEPPAVRKPPRPLPGFPCEFQPPGTTNCTSKIKRRSIKDRDPKPILDTQATANRQTPGKQKGLPGRDLLYPSYAIHNAAAYLPSWNAAKGGISNQTVNTNVIHQNGLAMYDTHNLYGTMMSSASHTAMISRRPNERPLIITRSTFAGAGTKVGHWLGDNFSDWLHYRMSIRGMLAFASIYQVPMTGADVCGYAEDTNEELCARWAMLGAFTPFYRNHNAYPPTISQEFYLWPSVTEAAKKAIDIRYRLLDYIYTALYRQTLDGTPLINPMFYLYPSDPATFALETQYFYGSGILVSPVMEPNSTSVEIYLPDDIFYDFYTHAPILGQANTIQMTNLNLSSIPLHYRGGVIVPQRIESGMTINEVRKKNFEIIVPVDKDGMAKGELYLDDGVSVLGKDEEGYAYSLIHFSWDGKNFDVRGYFGFDSGVSIERVVFLGLGNAVVNGNSNETSGYGREDAVNVDENVDENKSKNENVQVNEQGDVVVHIGKELNGGFSVTI
The following text describes a protein:
Function:
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Note=Shuttles on curvilinear tracks between nucleolus and cytoplasm. These tracks extend from the dense fibrillar component of the nucleolus across the nucleoplasm to a limited number of nuclear pore complexes.
Sequence:
MADTGLRRVVPSDLYPLVLGFLRDNQLSEVASKFAKATGATQQDANASSLLDIYSFWLKSTKAPKVKLQSNGPVAKKAKKETSSSDSSEDSSEEEDKAQVPTQKAAAPAKRASLPQHAGKAAAKASESSSSEESSEEEEEEDKKKKPVQQKAVKPQAKAVRPPPKKAESSESESDSSSEDEAPQTQKPKAAATAAKAPTKAQTKAPAKPGPPAKAQPKAANGKAGSSSSSSSSSSSDDSEEEKKAAAPLKKTAPKKQVVAKAPVKVTAAPTQKSSSSEDSSSEEEEEQKKPMKKKAGPYSSVPPPSVSLSKKSVGAQSPKKAAAQTQPADSSADSSEESDSSSEEEKKTPAKTVVSKTPAKPAPVKKKAESSSDSSDSDSSEDEAPAKPVSATKSPLSKPAVTPKPPAAKAVATPKQPAGSGQKPQSRKADSSSSEEESSSSEEEATKKSVTTPKARVTAKAAPSLPAKQAPRAGGDSSSDSESSSSEEEKKTPPKPPAKKKAAGAAVPKPTPVKKAAAESSSSSSSSEDSSEEEKKKPKSKATPKPQAGKANGVPASQNGKAGKESEEEEEDTEQNKKAAGTKPGSGKKRKHNETADEAATPQSKKVKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGSISVQVNSVKFDSE
The following text describes a protein:
Function:
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane.
Domain:
Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
Sequence:
MFENLQDRLGSILNGLTGRGALTEADVAAALREVRRALLEADVALEVVRSFTDRVREKAVGAAVLKSIKPGQMVVKIVHDELVEMLGTEGVSIDLHAAAPVVIMMVGLQGSGKTTTTGKIAKRLTDRDKKKVLMASLDTRRPAAQEQLRQLGVQTGVDTLPIIAGQSPTDIAARAVQAAKLGGHDVVILDTAGRTHIDEPLMLEMADIKKKSNPHEILLVADSLTGQDAVNLARNFDERVGITGLVLTRMDGDGRGGAALSMRAVTGKPIKLIGIGERMNELDEFHPRRIADRILGMGDIVSLVEKAAENIDAEKARSMAEKMAKGKFDLNDLADQLGQMKKMGGMGGIMGLMPGMAGMKDKMASAGMNDKMFDRQIAIISSMTKAERANPDILKHSRKKRIAAGSGTDAAEINKLLKMHRGMADMMKAMGGKGKGGIMKQMMGGLAGKMGLGGMMGGGMPDLSNIDPKQLEALQKQAEAAGLGKPGAMPGMGGLPGGLPGLGGAKLPGLGGMPGLPGFPKKK
The following text describes a protein:
Function:
Probable oxidoreductase.
Sequence:
MSLESDITRNLPSLQFQSAFDETDGHYLHLRIRSYILTVAACAQATYFVSVLNELRQVVLEEYSSRVVHRPSSSRILNTSIQRDPVKVGIIGCGRLGRQLATSLLAFAGVRPEELFISTRRPELLQDLAQRGVWCSFDNQCLCNKVNVLFICCLPSQFGTVAKDIQSFLLSNTIVYSLVGATTIDRILQSLRFDNVIRPEFSWATNVTERNLEKHWNTSKDIIQALYDSRIIASCCPLSLNKEGLQDNSTEEHGFVIEDLQAVIPNDQIISKEDNITSTNTDRSTKLFPIFNFKLAYFSHTHIGYKVCYEGIRKNFIKNFSSKFGKVKVWKGYRSENLTKN
The following text describes a protein:
Function:
Methionyl-tRNA formyltransferase that formylates methionyl-tRNA in mitochondria and is crucial for translation initiation.
Subcellular Localization:
Mitochondrion.
Sequence:
MLLSRVRPRRSIFRSITNASAQRHFANVSRLKVLFFGTDHFSLPSLKSIHTNLVNNGRVERLEVVTSFKAAKNPVKQYSRAAGLPLHDWAACTPATAGRFDLGVVVSFGHLIPETFIDCFDRGMLNVHASLLPKLRGAAPIVHAIANGEQRTGISIMRIKPKQFDVGEILLQSAVSIGRDTLMPELHDRLAAIGADCLVTCIEDLEGYYQRLTVQNDAEATYAPKIDPKFAEIRWHQATAVSVYDRYRALYGLRPLLTNFGGELVKLFKLSFDSTQSVPAVPADRPGQLEYSKRSRQLLVRCGDGRALELLQLSVGGKKTLSGQDFYNGFLSKVNRSDRYFK
The following text describes a protein:
Function:
Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development.
Subcellular Localization:
Nucleus.
Sequence:
MKKLAVGWEPVISNKWQNRRKAWRLFERNQQVAGAATAAPLFTTLAAPRRVPPPYPPVFFAHLPSNAPLMGQNVWILFGFGLFSLLCVDVPLCFLLLSSSRFSYHPFSLTHSKSLQVTTINMQHTSGSPQQFCLRWNNYQSNLTNVFDQLLQSESFVDVTLACDGHSVKAHKMVLSACSPYFQSLFFENPCQHPIVIMRDIKWPELKAAVEFMYKGEINVSQEQIGPLLKVAESLKIRGLADVNGEQDIVAPTGELTTSTRTLLKTASTPNNGSGEWECRPEGDGPPRVKKRRRPSGERSSLSSPAESASTEIPDPPPSVEMSPAPSATPLPSSVSNEPLPLTLPLPQQPQVSHASSDDMEIKPGIAEMIREEERAKLLESSHAWLGASTSSIADYPTLLKLKTPTWTQEQLKEAIDAVVKQKMRFTQASARYGIPKGTLYDNILGKSKRMAVLEEAGLTPSEEAAVLEFCCDVSVSPYNRRTKKSLQSVLNFVEKLRRARDPEFIFTGLSGFRWWWAFCKKHNIVSLYYENNGSMHSLNNTL
The following text describes a protein:
Function:
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Subcellular Localization:
Chromosome.
Sequence:
MALTRHGRSSKLVRKEDLSKKKTSQLNKASKIMTKKVTLVKALSTEKLQQLMPESNNVKKKSKTKSPAPTRSLLTRAAAARRSLDQTDVLFQNPESLSCNGFTMCLRSTSLIRRLSQPPVVITRPGKIPPSKTLEKENKCENGVLAVSKEHIVETEKETDQSQEKVISTDNEEDPIVVTSDALPSKENGQAVEDPITSITTHSSLPTQTSETLEENCKCEGQFFEKLLNDSSDTVRTLVQDSMPIPLFNNAPHTVTSKPNLNMYLEDLGSRVKSLKLNDSSLEPMKENLDSHQSSCYKGKPELDFQNIMVPSGSIFPTSFANYLLAGSDQQEPIHGSLDQPVTQSTASDPLGGHGANQTLTLDSGQIASSFPNFEKSLVAFTKDILAQEMHKPQDTSLLSELPSNNHSFKIVPESGLKKESNSLSEDPKLASSDLGQLDGQSSQISETNVISVSMAFSNTASYSYPFSYTTLLPTLEKKKRKRCGVCEPCQKKENCGECVYCKNRKYSHHVCKMRKCEELKKKPMVIVPLEVIKENKRPQREKKPKVFKIHLDNKLVNGPRSESMENSKCGNDEKQRLKLNQNILENVQTTEEDTMTGIEVEKWSENKKSPLTIHVKGDISGPVTETENLKNSEDNEKKTPLSDLIEPPKLFAQTVKNGIKNVYYSPADADVSLKKVKFETNANLIDHDTESNPNPSLGNTTSSDNRAGALVPGIYHAHLKKEDNSLVIQKTDSTCHSTQYPTDTFLNHNISAQENQSHIVTWEKRFDQGEVPESKPNRELAQDNSLVQPSLLTLMRDRRLTLEQVVAIEALTQLSEAPSENSSPSKSDKNEETTNLTTNLLHSCKAILCSVGSSAGKDFQDPNLKIDSVVLPPCPSLEKKTSRKPVLYNGQNNSKYPSTLMTNHNTSKTHASSRVTKSGLITEPSSNSSRNHSNKEIVLQGRITVGRCAKTSHGLHTSSKLAFCRQLQESTGKRFDSKNNLSYKNTPHSQIEEDVAAQLTQLASIIESNNAKREEKEGTKTLSSLESHDAQQKYNQEQSSFQEKLPVPVQNNRGSLLAKQKPSSHKKGKSASWKQRLKKMPPAKNNLQNDQSERERLAWQYGKFHDLWVGSKLRRLGYISSREFHATMIEQNPLLTKVPKPLTQSTLSSPHKKVFLPLTQIKFHRHLPESAQEKMKEKLFGFKEVPEHMQPEAVDTLPRGALPAGLQQSGGPSVDALSLFQLCSKSPLSRPSSNVQVFTENGHNSQVQQSVNVNQSLNQNSQKDGATADDDQTQFQQDVEEPPRSQRLQSLPSPCCDTQVPGTIKTLRNENAACPGGRTASGLGVVTSHGATSDLGSSPGKNTLSCFLESPMTFLDTPTKNLLDTPTKKGPSELPSCSCVEQIIEKDEGPYYTHLGTGPSVAAVREIMEARYGEKGRAIRIEVVVYTGKEGKSSQGCPIAKWVIRRSSDEEKLLCLVRQRAGHHCQTAVIVILILAWEGIPHLLADTLYQELTQSLNKYGCPTTRRCALNEDRTCACQGMDPETCGASFSFGCSWSMYFNGCKFARSKNPRRFRLIADDPKEEEILESNLQSLATDVAPVYKKLAPDAFRNQVENEPLGPDCRLGRKDGRPFSGVTACIDFCAHAHKDTHNMNNGSTVVCTLTKEDNRSVGVVPKDEQLHVLPLYKISQTDEFGTKEGLEAKIKTGAIQVLTAFPREVRMLAEPVKATKKKKVDIRRVQTEKPGQVPKKHPPPVKLKNGPLEAPNRAPQPLGNRTEALQPEIKSEPPDSHFNLHSVANTTSYSWIKSIHHPLKGTNLPLNSPLTPVSGLATTSFQNDSEISYGFSDQGSVPPWTVVSTKYSGANTVAKECPGLLLNAKPASVPGVASPMTDPQIHADLPTGPVEHLVSNMATFPPPSLLSPVPQIPSLDDSTPAKSDYEHKTGPSEVAALAPSLANATKQELELAAPLSSATEQTPSDELTESADSEERSEEMWSDSEHNFLDDNIGGVAVAPSHGSVLIECARRELHATTPIRKPNRNHPTRISLVFYQHKNLNEPRHGWAVWEAKMAERAREKEREAERLATENANNQKTKQPTESPEIFCEENELNQIPSRKALTVTHDNVITVSSYALTQVAGPYNHWV
The following text describes a protein:
Function:
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
Sequence:
MSTIVTVPRSVSWKGDAIAVLNQTKLPHSTEYKTLTTIEEVWKSIIMLEVRGAPAIGIVAAFGLALAAKKYNTLHIEEFQKKFNRDCNYLGTSRPTAVNLFWAIDRMRESIREITTIKEAQKILEEEALRIQQEDEEVCRNIGEYALTCFKDGDNILTICNAGSIATARYGTALAPFYIGKEKGVRLHAYACETRPVLQGGRLTTWELKQANIDVTLITDNTAAHAIQTKEINAIIVGADRIVANGDTANKIGTMNLAILAKYFNIPFYVAAPLSTFDVTKETGAEIIIEERDETEVTKIFGKQVAPIGTDVYNPAFDITPNELITGIITEKGIIRGDYKREIASLFEKQANT
The following text describes a protein:
Function:
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MVRYRVRSPSERPQSGPGQQHGGEDQGQESGHTPENIEAARRTAGSYYRYRRRRCSPRRLYRLRRRRYRSSRRRRRRPCRRRRHRRVCRRVRRRRRCRRRY
The following text describes a protein:
Function:
Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit plays a role in transcriptional response to stress. It is involved in both repression and activation of mRNAs regulated by the target of rapamycin (TOR) kinases, and in the synthesis of rRNA.
Miscellaneous:
MISCELLANEOUS: Present with 2610 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Note=Localizes to centromeric and flanking chromatin. Association with these loci is dependent on STH1.
Sequence:
MNSLASNTPLNGTPVSEAPATSSEPVNMFETMVANPIKVSRLQSNGVLTGPAANTKSIHYSLANFNVFQSLPKETARGVDDLTRMEMALLSGIPEEIKWSLKKYLTYSNKAPYMISLRTLPDLLPLFKTFILPLERIVEGLNKSSICDSKAMDSLQMGLNALLILRNLAQDTDSVQILVKDREIKSFILFILKKFQCVATGDNKWQLYEGNATFFNELTHYTLDLMEAISSYIAPAMKDDHYFQTLVSILNYTKDRYMVISILRSLSRLLVRSKANEESAADNLDHKTLSLIVSFLLLECDSELIIASLDFLYQYILPGSQRITELFKSKECSLILEATLPNLLSYNIATPDYHLLQKHKIRLIKRLKPPAPKEPPNLSEDLFQQLFKLNEPLRSTAWLRCCFEPVQEAEFTQISLWRSYESKFGQPVRESGRKLLPAVEFIKNVSNAFNNAAAIVITDPVTGKKRFVIKGIQPRFKALGIADGERESQVPISALKSKFLNDSKEITPARQNSIPEVKFPQELSDVSKVACTFLCLLSNDTDDGAGSAFCQRIRPLVLHKLADIPPLTLALSEYMENTSGL