lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transporting tripeptides. Probably responsible for the translocation of the substrate across the membrane (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAVILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVSLLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKPGVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALGPIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPGLFILMTVLCFNFVGDGLRDALDPKNIK
The following text describes a protein:
Function:
Antifungal protein that inhibits the growth of several phytopathogenic fungi (e.g. Trichothecium roseum, Fusarium oxysporum, Phytophthora citrophthora and Colletotrichum coccodes). May bind to beta-glucans and have beta-1,3-D-glucanase activity (By similarity).
Subcellular Localization:
Vacuole. Note=Accumulates in vacuoles associated to dense inclusion bodies.
Sequence:
MAYLRSSFVFFLLAFVTYTYAATFEVRNNCPYTVWAASTPIGGGRRLDRGQTWVINAPRGTKMARIWGRTNCNFDGDGRGSCQTGDCGGVLQCTGWGKPPNTLAEYALDQFSNLDFWDISLVDGFNIPMTFAPTNPSGGKCHAIHCTANINGECPGSLRVPGGCNNPCTTFGGQQYCCTQGPCGPTDLSRFFKQRCPDAYSYPQDDPTSTFTCPSGSTNYRVVFCPNGVTSPNFPLEMPSSDEEAK
The following text describes a protein:
Function:
Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 (By similarity).
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MKFSVLVLLASYLVGVNSSIVDTSEELICPDPENPLDCYPKLFVPTNEWQTIKPGQDIPPGLHVRLNIDTLEKEAKLMSADEKDEPVQEVVVGGELQDHSREAITENLQKLHESKHPEVKQEHAHRTKVSQGDLSNFDAACSEIESFKPHESDVERLHLALDTLEELSHDIEFGVKLTSDKAIFQSLVNIANGASDPKITEKVYRVMGSSLRNNPEAISNILTNFDKSYVDNLFEQLANENDVLQKRILGIIQALVQNSHFVRQYFSFDHSSGLNDLIAIFPKLGPNSKSRASNILEDLQLFPVTNDRRSLEDQDPESQVSKFIQNSFVGNKLDEKNFKSYFDQLVNLHQSNKSLRPSGDFLNWLAEEVESRKENKKRDDYSQEDKDFDEYMLRARHEVFGNPMGLRKAIADEL
The following text describes a protein:
Function:
Pseudouridine synthase that catalyzes pseudouridylation of mRNAs.
Sequence:
MFGIECYVSQHEGFKGNVKTSPKDFQVTEISPDGRLASLIDIKIDLSSKLGIKFRDGSEHSNTSAIDSTPTPLHSKAASDTSTSTSVIDSHIQSELSSIQVNKVKVSQEGFIPKDSRKCLENVLDKDIFIELEKFATIELKSLGRSNPESCTETNTASSTILEPHQAHLNLGLISSKESRTIIHKCVRHLYPHLRTKVHKVPDQGGLEIHISREPGIAEFQDLQIPLSKVLEFFKFVELRDREQTFCFEGLESKDQRTKLHRLVAKHYGSFLETKTFGDGASTREHQKIVVRFRQIKDHKKRKGGDGHSARDSVLTGFTLQKTNTETLSAIQQLARLMGVQISDFTYAGIKDKKAVTTQEMAVKGITITRLQDVSKELPGWLKVGSIHSRNKSMVTGELWGNHFDITLQNIEMKNGSNEVRAGTVEDKGRELQNCIEQCIRCVEDRGFINYYGEQRFGASSVDPSKALTTISPADVGCAMLQGKYKEAIDLILSPDDGPCADPSNATNVAKHCFQQTGSPREALKQMPTMKTRECLLLKGLNRHGTDDDGCIKALMNIPHNMRQMYVHAFCSLVWNQMASWRMCRYGCQVVEGDLVCIEDLGTKVHAVTEDDITQGKYSLTEVMLPLPGNNIQYPSHTAGAEYQRRLDEAGLGECNFRIPALKLNVPGGYRKVIAQPRNLEWGWGVSRDKHVDNEDDREDYTRDTKDAPLPSNHAASPFGNTSDALSSSSIVTVGCPNLMEASGRHMELSCNESDSDPAVCYSEKTNEISAGRPLGSPACVSECHMVSYSADIKDDFTASIYDNTLSTDTTKAIGGPNSADSPTLYHNDISQSLCHSRDKSSYTNTQCDVSQSSSLSCQRKTLNLSFDLPASCYATVFLRELKKS
The following text describes a protein:
Function:
Involved in the final steps of cholesterol and steroid degradation. Probably catalyzes the introduction of a double bound into the C ring of 5OH-HIC-CoA, leading to the formation of (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA (Probable).
Sequence:
MRLRTPLTELIGIEHPVVQTGMGWVAGARLVSATANAGGLGILASATMTLDELAAAITKVKAVTDKPFGVNIRADAADAGDRVELMIREGVRVASFALAPKQQLIARLKEAGAVVIPSIGAAKHARKVAAWGADAMIVQGGEGGGHTGPVATTLLLPSVLDAVAGTGIPVIAAGGFFDGRGLAAALCYGAAGVAMGTRFLLTSDSTVPDAVKRRYLQAGLDGTVVTTRVDGMPHRVLRTELVEKLESGSRARGFAAALRNAGKFRRMSQMTWRSMIRDGLTMRHGKELTWSQVLMAANTPMLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKELIESIVLDAITHLQTASALVE
The following text describes a protein:
Function:
Mediates the hydrolysis of steryl esters (SE). Preferentially hydrolyzes ergosteryl and zymosteryl esters. Required for mobilization of SEs from lipid particles/droplets, thereby playing a central role in lipid metabolism and sterol homeostasis. Sterol intermediates stored in SE and set free by SE hydrolases are recycled to the sterol biosynthetic pathway and converted to the final product, ergosterol, in the endoplasmic reticulum. Also has weak lipase activity toward triglycerides at neutral pH, however, the physiological relevance of this activity is unclear.
Miscellaneous:
MISCELLANEOUS: Present with 1470 molecules/cell in log phase SD medium.
Subcellular Localization:
Lipid droplet. Membrane; Single-pass membrane protein. Note=Partially retained in the endoplasmic reticulum in cells lacking triacylglycerols and consequently lipid droplets.
Sequence:
MYFPFLGRLSITDYIIVVLVYIESIISSVLKLIPQPMINLFEWLINFSTSSDDNTIEEKLRSAPTIHEMCAIFDISVEDHLVRTEDNYILTLHRIPPISKNRFNNKVVYLHHGLLMCSDVWCCNIERHKNLPFVLHDLGYDVWMGNNRGNKYSTAHLNKPPKSNKFWDFSIDEFAFFDIPNSIEFILDITKVDKVICIGFSQGSAQMFAAFSLSEKLNRKVSHFIAIAPAMTPKGLHNRIVDTLAKSSPGFMYLFFGRKIVLPSAVIWQRTLHPTLFNLCIDIANKILFNWKSFNILPRQKIASYAKLYSTTSVKSIVHWFQILRSQKFQMFEESDNMLNSLTRPYQIANFPTRTNIKIPILLIYGGIDSLVDIDVMKKNLPFNSVFDVKVDNYEHLDLIWGKDADTLVIAKVLRFIEFFNPGNVSVKTNQLLPSASLVEELPSTTWKTTHPTHGLSYRTHSADRSPLSVQADEADEVHNADNSRFLRRVFSTSAIDEDNENEHQDDTEDQIHKEQQRRLSAYLESSKDLRQLDANSSTTALDALNKE
The following text describes a protein:
Function:
Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
METTVLQNKISRLLSTSYTDGGTRDALVALDDRITDNTASIRRSLRANTEAEVIKANGEALKKFAPLVAQIQASGNTIADLNHKFTLMQQLVNTCKNDTRHVVSEGSELMAQQENISKKRDLLKRYTDAFVLTEREMDILKGNDEVPFETFKQVFIKAQKIHKDSEILLANDDTRAGQITMYKANQALENANNTLIRDTETSLINYAQLGETDNFKQDPQLRERLSLLNDVNRAKTLGQFTETRRRQLLKSFTSALTENSQKNGTKALDFYAYDCQRYIGDILAWVYSCVVLETENTSILIGQNDSELVDNCTQSLCSPLRLRVERAVASQTRGPQIFKIAGLVEFYKSMLSKHLPNSQLVDTLTQLTAFCNTHFTKTCESRVRNVSVSLPTTLSSDLQPPEFLTQTLVDLKEILEANQQYSLDEQVVRKHIDNSLDPYMEFCRRVASDGADFDAEIFLLNCLDQIIITLKLYSASEYKVDSFQSSVDEIEQVLTERLFHKFVKQVGLGEDLEPAHLSEISFQLDDFLPSALTDLHSMLFRISSPVIVDNIARNSTKKFVEEFSKLEGKVKDTYKVESDYRQFFPRTTEDVELLLGLRS
The following text describes a protein:
Function:
Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration.
Subcellular Localization:
Nucleus.
Sequence:
MPQAFLLGSIHEPAGALMEPQPCPGSLAESFLEEELRLSAELSQLQFSESVGVIYNPLEYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVSIVRDWLGIGGPVLTPPQEHPKRPVLGLECPQSEVSGARFWGFFRNLCGQPEVFFHHCFVHNLCPLLFLAPSGRNLTPAELPAKQREQLLRICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLMPEVQVEGLLHPSPRNPQANKGWEAVAKERLNELGLLPLLLK
The following text describes a protein:
Function:
Together with the closely related MLP2, involved in the structural and functional organization of perinuclear chromatin. Together with MLP2, associates with the nuclear pore complex and form filamentous structures along the nuclear periphery. Has a role in the localization of Esc1 to nucleolar regions. Together with MLP2, mediates tethering of the some telomeres to the nuclear periphery, probably mediated by YKU70/YKU80 (HDF1/HDF2) heterodimer and show perinuclear location dependent silencing. MLP1 and MLP2 are involved in telomere length regulation but not silencing or telomere anchoring. Recognizes the 5'-splice site of pre-mRNAs and retains unspliced pre-mRNA in the nucleus without affecting splicing itself.
Miscellaneous:
MISCELLANEOUS: Present with 2710 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Nucleus, nuclear pore complex. Note=Distributed fairly evenly along a C-shaped portion of the nuclear periphery, where the spindle pole body localizes in 90% of the cases.
Sequence:
MSDHDTPMESIQNGENSDERLNAIASFFGCSLEQVKSFDGDVVKHLNDKLLQFNELKSENLKVTVSFDELKASSLKKIDGLKTEMENVIRENDKIRKERNDTFVKFESVENEKMKLSSELEFVKRKLDDLTEEKKETQSNQQRTLKILDERLKEIELVRVENNRSNSECKKLRSTIMDLETKQQGYITNDLNSRTELERKTQELTLLQSNNDWLEKELRSKNEQYLSYRQKTDKVILDIRNELNRLRNDFQMERTNNDVLKQKNNELSKSLQEKLLEIKGLSDSLNSEKQEFSAEMSLKQRLVDLLESQLNAVKEELNSIRELNTAKVIADDSKKQTPENEDLLKELQLTKEKLAQCEKECLRLSSITDEADEDNENLSAKSSSDFIFLKKQLIKERRTKEHLQNQIETFIVELEHKVPIINSFKERTDMLENELNNAALLLEHTSNEKNAKVKELNAKNQKLVECENDLQTLTKQRLDLCRQIQYLLITNSVSNDSKGPLRKEEIQFIQNIMQEDDSTITESDSQKVVTERLVEFKNIIQLQEKNAELLKVVRNLADKLESKEKKSKQSLQKIESETVNEAKEAIITLKSEKMDLESRIEELQKELEELKTSVPNEDASYSNVTIKQLTETKRDLESQVQDLQTRISQITRESTENMSLLNKEIQDLYDSKSDISIKLGKEKSSRILAEERFKLLSNTLDLTKAENDQLRKRFDYLQNTILKQDSKTHETLNEYVSCKSKLSIVETELLNLKEEQKLRVHLEKNLKQELNKLSPEKDSLRIMVTQLQTLQKEREDLLEETRKSCQKKIDELEDALSELKKETSQKDHHIKQLEEDNNSNIEWYQNKIEALKKDYESVITSVDSKQTDIEKLQYKVKSLEKEIEEDKIRLHTYNVMDETINDDSLRKELEKSKINLTDAYSQIKEYKDLYETTSQSLQQTNSKLDESFKDFTNQIKNLTDEKTSLEDKISLLKEQMFNLNNELDLQKKGMEKEKADFKKRISILQNNNKEVEAVKSEYESKLSKIQNDLDQQTIYANTAQNNYEQELQKHADVSKTISELREQLHTYKGQVKTLNLSRDQLENALKENEKSWSSQKESLLEQLDLSNSRIEDLSSQNKLLYDQIQIYTAADKEVNNSTNGPGLNNILITLRRERDILDTKVTVAERDAKMLRQKISLMDVELQDARTKLDNSRVEKENHSSIIQQHDDIMEKLNQLNLLRESNITLRNELENNNNKKKELQSELDKLKQNVAPIESELTALKYSMQEKEQELKLAKEEVHRWKKRSQDILEKHEQLSSSDYEKLESEIENLKEELENKERQGAEAEEKFNRLRRQAQERLKTSKLSQDSLTEQVNSLRDAKNVLENSLSEANARIEELQNAKVAQGNNQLEAIRKLQEDAEKASRELQAKLEESTTSYESTINGLNEEITTLKEEIEKQRQIQQQLQATSANEQNDLSNIVESMKKSFEEDKIKFIKEKTQEVNEKILEAQERLNQPSNINMEEIKKKWESEHEQEVSQKIREAEEALKKRIRLPTEEKINKIIERKKEELEKEFEEKVEERIKSMEQSGEIDVVLRKQLEAKVQEKQKELENEYNKKLQEELKDVPHSSHISDDERDKLRAEIESRLREEFNNELQAIKKKSFDEGKQQAMMKTTLLERKLAKMESQLSETKQSAESPPKSVNNVQNPLLGLPRKIEENSNSPFNPLLSGEKLLKLNSKSSSGGFNPFTSPSPNKHLQNDNDKRESLANKTDPPTHLEPSFNIPASRGLISSSSTLSTDTNDEELTSNNPAQKDSSNRNVQSEEDTEKKKEGEPVKRGEAIEEQTKSNKRPIDEVGELKNDEDDTTENINESKKIKTEDEEEKETDKVNDENSI
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSHEEDLIDYSDEELQTTDAAATTAAPAANGAQDKKGDLTVSGGRPDKKGSYVGIHSTGFRDFLLKGELLRAITDCGFEHPSEVQQVCIPTAILNVDVLCQAKSGLGKTAVFVLTTLHQLEPVPGECSVLVMCHTRELAYQIKNEYARFSKYLPDVKTAVFYGGTPIQKDIEVLSNKESYPNIVVGTPGRLNALVREKKLSLRNVKAFVLDECDKMLDQIGKQAQIAHMRRDVQEIFRATPADKQVMMFSATLSQEIRPICKKFMRNPLEVYVDDDTKLTLHGLQQYYIKLSESEKNRKLNELLDSLEFNQVIIFVKSTLRANELDKLLRECNFPSIAVHSGVSQEERIKRYKEFKEFNKRICVATDVFGRGIDIERINLAINYDLPADADSYLHRVGRAGRFGTKGLSISFVSSEEDEKVLKEIEKRFEVALPEYPEGGVDSSTYMA
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLKLNCKPPRTLKRITNNKLTKYRLYATEINPAQPIKPVKKKGIFRKLILPTTLLGGTLYGAGIYGSFQNDKFRDFFMDQVPLGEKLLNFFEESNLEHVADLSKGTMEVLDQSIKKIKTVTGITTSEEKTRQKDSPTLEKIKAKTEAAVQRGKDLSQDISNSLPNPPKNLNPNLTTKHSGPSTTTTATKVPISDEAPISLPQPSAQTGMPTYNREIPIGHEPPPGYRGSAPRPRDPSTEPLPPPPALPLLAPTVKNLSSSEPILGQLASSIDSLAGFLRDHPDVVVRGKDPSGKDAPRVLSTASEELKNLAGRLETIKSEKQAQLQNQLESQAKEYGKILLDAERELHQRLDQQEESWKNTFDQERSKLAKSFEDKLAKELETQQALINERLEQEVISQGLEMQRRWMREIKSQVELEREGRWGKLAELEGCMKQLGRVTLDNEEYLEDHLRINQLWNAIRAISASAFENHSKVPLDHEARALQRISDRAKKANAAVAEEGSGGGASSCDDVISVALESMPAVAIDAGVESLPGLTLWFKNSVSPRIQSASLLPTQGGLISYFTSHILSNFFFTNLAPQTATTTTTSLDHQPQDPISILNQVNALLDVKDLEQATRLLNSLNGWPKVLARDWLQAARRHLELHQAIQVIEAEATLQSLLL
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MEASLSLFRPVATCCRRVALSSSSSSSQKAAAVAGISVRYQSTANRTKRMLNIPPHESFLNVPVEGDRIIFNPPSSEASVYHTPFKFLPRSDPRRRANIYKLFKPPQAPITTPESSSTDAAAADQHGDLPPVLYNPTKSYNVTPEQVEEIRELRAKDPKKYSVTYLSNKYNCTKVFIMMCTQAPREHQEQHKLARARTAENWGPRRAAAKLDARRRKEMLHRGEI
The following text describes a protein:
Function:
Acts as an effector of RABF2A and RABF2B. Involved in vacuolar transport of storage proteins. Regulates membrane trafficking to protein storage vacuoles (PSVs). Binds specifically to phosphatidylinositol 3-monophosphate (PtdIns3P).
Subcellular Localization:
Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein.
Sequence:
MAGRSPPRHRHDGSSPLPLGMDASPAPARWNGPQTVWPHDPRTGWSYCVFIPSWVAVPEGKESDGKAINPKVFFEVQVGIQSPDGISTLRPILRRFSDFLKLHAAVKKLFPKKKLPAAPPKNSLMRINSNQALLKERRHTLEDWMGRLLADIDISRSVPLASFLELEAAVRSAISERQSQLSVTSSIPLQSTSKLRSGVSWTGGGSSVVSHGYSTLDYGSDATYENSVVGTPSKGSEGELEAEMEALALEEQTASIAAAIESRENQQQEKITSVGLISNSSERVGMGMQTRAVFMDYVAADEPSSQNQPPNGQEMPAVTTVNQVGLAGTSLDETSLKSPLSLGSRHRHRTSQESLSSEISSAPGSDLLRGVSMDLHTENPLMSSSGANPSGEPHSPDAESLKGVGTVFPADQRSKVKRVMGTLQRRFLTAKTDMEDLLGRLSQETAVKEFLTTKVRDLESEIDGMRRKSREVLQRAVWAERERMISLQWELDDCRVALQSSEENVQSLQASKGQLEEKLQEVLAKFETMEKELADVNQQYHSLQQEGDSVDAQARAEKKVLAKEVKNLRASHMEIKQEVKQAMQAKASLEAILSEQKQKQEKAQVTRVKFVREIAMLQARLRECNMDELYKRNGSLGRTEASDMVATFESRISLLIGQAQLLVQEDEELRKADSSTHWPSPRLHEESNGDSGVTFYTDKDSEAALRKMLIDAFIEQAQLCRSLNSLTCNALMSKEAT
The following text describes a protein:
Function:
Involved in ER-Golgi transport. Also involved in retrograde (Golgi to ER) transport.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Note=Associated with the peripheral membrane of cis/medial cisternae.
Sequence:
MAEAAAERDAREKLSLWDGRPDSMAPLTDRQTDSVLELKAAVENLPVPAELPIEDVCSLASQSLPIELTAVVPDSTEDILLKGFTSLGMEEERIETAQQFFSWFAKLQTQMDQDEGTKYRQMRDYLSGFQEQCDAILNDVNSALQHLESLQKQYLFVSNKTGTLHEACEQLLKEQSELADLAEHIQQKLSYFNELETINTKLNSPTLSVNSEGFIPMLAKLDDCITYISSHPNFKDYPVYLLKFKQCLSKALHLMKTYTVNTLQTLTNQLLKRDPSSVPNADNAFTLFYVKFRAAAPKVRTLIEQIEQRSEKIPEYQHLLNDIHQCYLDQRELLLGPSIAYTVTELTSQNNRDHCALVRSGCAFMVHVCQDEHQLYNEFFTKPTSKLDELLEKLCVSLYDVFRPLIIHVIHLETLSELCGILKNEVLEDHVQHNAEQLGAFAAGVKQMLEDVQERLVYRTHIYIQTDITGYKPAPGDLAYPDKLVMMEQIAQSLKDEQKKAPSEASFSDVRLEEGEASGLRKSGSTDSLNPRPQTTISPADLHGMWYPTVRRTLVCLSKLYRCIDRAVFQGLSQEALSACIQSLLGASESISKNKTQIDGQLFLIKHLLILREQIAPFHTEFTIKEISLDLKKTRDAAFKILNPMTVPRFFRLNSNNALIEFLLEGTPEIREHYLDSKKDVDRHLKSACEQFIQQQTRLFGEQLEEFMTKVSALKTMASQGGPKYTLSQQPWAQPAKVNDLVATAYKTIKTKLPLTLRSMALYLSNKDTEFILFKPVRNNIQQVFQKFHALLKEEFSSEDIQIIACPSMEQLNLLLSVSK
The following text describes a protein:
Function:
Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome.
Sequence:
MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGTFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGSPSTDASASDVHGNFAFEGIGDEDL
The following text describes a protein:
Function:
Possible tumor suppressor which may play a role in cell growth.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPCTCTWRNWRQWIRPLAVVLYLLSIVVAVPLCVWELQKLEVGIHTKAWFIAGIFLLLTIPISLWVILQHLVHYTQPELQKPIIRILWMVPIYSLDSWIALKYPSIAIYVDTCRECYEAYVIYNFMGFLTNYLTNRYPNLVLIIEAKDQQKHFPPLCCCPPWTMGEVLLFRCKLGVLQYTVVRPFTTIIALVCELLDIYDEGNFSFSNAWTYLVIINNMSQLFAMYCLLLFYKVLKEELSPIQPVGKFLCVKLVVFVSFWQAVVIALLVKVGVISEKHTWEWQTVEAVATGLQDFIICIEMFLAAIAHHYTFSYKPYVQEAEEGSCFDSFLAMWDVSDIRDDISEQVRHVGRTVMGHPRKKFFPEDQDQNEHTSLLSSSSQDALSVASSVPPSPVGHYQGFGHTVTPQTTPTTANASDDTGNDAAGVREEPSEKPVAS
The following text describes a protein:
Function:
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Sequence:
MQLRDLLTQATARLTRAGVPSPEVDARLLLEHVLGLNRTAFLLRGGEEIGPDAEARAWDSIERRAARVPLQHLTGEVEWGGVRLTSDARALVPRPETEWLLHLALEELRRVEKPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSGLDVKFVEGSLLAGLSGPFNLIVSNPPYLPTADRATADPEVRHDPDLALYAGEDGLDVARPLVAEAAAALVPGGALLLELDPRNAPTLAAELRTAGWQAEVRPDLTGRERFVRARRAGG
The following text describes a protein:
Function:
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MAKSRLFCLLVALGSVFMILFIIVYWDNVGTANLNLHTSFSKSLPFQSSEELSTAVTATRNRFVSDVDVFLNSFLNLSTRRSELQSTKAEKMPLRGSSSLEENARGYDWSTKEKLEDAILDQEMIQQERKLNLLQFCGNSSFGFPTKERSFDDIPNRELDHLIVDDRHGIIYCYVPKVACTNWKRVMIVLSESLLDKKGVPYQDPLLIPREDVHNTSSHLTFNKFWRRYGKFSRHMMKIKLKKYTKFLFVRDPFVRLISAFRSKFELENEDFYRSFAVPILTRFSNTTRVPDTVGEAFSSGTMPSFSQFIQYLLDPQTEEQKPFNEHWRQVYRLCHPCQIEYDFIGKLETLGEDTALLLRQLNLDTLFQFPPSYRNRTASSWEEDWYSKLPIAWRKKLYKLFEADFVLFGYPKPDDLLSV
The following text describes a protein:
Function:
Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal.
Subcellular Localization:
Nucleus.
Sequence:
MTVQSKLQGRGKFKKRFFRAGQQVPRPTLELSSVWLSKIFYNPEQHHNKQKMIESGITTRMSGIHENPGQSHHTSAQDYRLLTTDPSQLKDELPGDLQSLSWLTSVDVPRLQQIGGGRPDFTSSAQSSLLERQTAQLNSMTVAGGAGSAIHLQSEMQHSPLAINSMPQFSPGFPCAASVYQTAPQQVLTFTQANQQCSPGGLYGNYNSQNLFPQPRITAHSQDLQPKCFPKPIYSYSCLIAMALKNSKTGSLPVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKMSGSSRKGCLWALNPAKIDKMEEEMQKWKRKDLPAIRRSMANPDELDKLITDRPESCRQKSVDPGMTRLPSCPPGQTLPLAAQMQPQPVVTLSLQCLPMHQHLQLQLQNQSRLAPSSPAPAQTPPLHTVPDMTNSSLPQHPAKQHTDFYTVHTDVNSEVDALDPSIMDFAWQGNLWEEMKDDSFNLEALGTLSNSPLRLSDCDLDTSSVTPVSSAGGLPYPDLQVTGLYSSYSAIDALSNQYMNTQGGTKPIVLL
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MGNKIHAGFTFTPSHARSLDCFVCLLVLFSFRSTPPHGRHPAIEPTLLISHYYRGQMLGTYNGDSKAETDGKDNSICHICSDVATGRHYGAIACNGCKGFFRRTVRRNYEYHCRFESKCEIDKHNRAVCRYCRFMKCISSGMRDDQVQSERDVIGKREKKDNMKTYCQDPTPRTSPELTMSPVEDEYDQLLESLLKSEMTIQSLRDTVITQTGNVEYTTKSKNRLSHTDRTATLNDVLKSMHSQLLLVIEWAKTLPEFKQLSGADQAVLLKNFAGQHVTLCVAYRSVGANDALKLLNDLYIPRASKTTPHLKEYVDGFYLRDCEKVMDQLVEPMRFLKLDNKEFVALKACVLFNPVAPGLSNHAVNLVLNARRKIFAAFEKYVRVNKPLETTRVGDLTFFILTPLSVLSKSISEDIMFTKVSGVARIDVLMEELILAETDYGEDRQDQTPCSIMNDTPSGSQDMCSPCPEDLLRTSTSSNSPTNSSLTAGLLLKTDDAMMSGIGTQYTTPQPHTPQFADSSHLNLPYAPFTSSYNQYPNTYS
The following text describes a protein:
Function:
Hydrolyzes UDP and to a lesser extent GDP. By preventing the accumulation of NDP, may promote the reglucosylation of incompletely folded glycoproteins in the endoplasmic reticulum following the unfolded protein response.
Subcellular Localization:
Endomembrane system; Single-pass type II membrane protein.
Sequence:
MTQESNSNFFNFLLFGFVTAIAFYSGTQFNKSSEQEEHINHANLYSVKKFDDGAKEYSIMLITDLDHDSKDGKKWKSLVSRGFLKVSADHKHADIHFDKDSEYYVDTNIAAGGRAMELSDLAVFNGKLYSIDDRTGLIYQISDKKALPWVLLNDGPGNVVKGFKGEWITVKDTELIVGGLGKEWTTTDGVYVNDHPMWVKHVSAHGAVHHENWKDVYIRVRRAAGIEYPGYMIHEAVQWSAIHRKWFFLPRRMSNEKYSEAEDENRGTNVLVIGNEELTDFEVVRVGSENNKSRGFAAFQFVPNTHHQLIVAIKSEEKDGKPVASYASVFDIHGNVILDEYLLHGPYKYEGIAFA
The following text describes a protein:
Function:
Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They act via the methylation of histones, rendering chromatin heritably changed in its expressibility (Probable). Polycomb group (PcG) protein involved in the repression of flowering under long day (LD) conditions. Regulates floret development.
Sequence:
MCRHQPRARLSPDEQLAAEESFALYCKPVELYNIIQRRSIKNPAFLQRCLLYKIHARRKKRSLITISLSGGTNKELRAQNIFPLYVLLARPTNNVSLEGHSPIYRFSRACLLTSFHEFGNKDYTEATFVIPDVKNLATSRACSLNIILISCGRAEQTFDDNNCSGNHVEGSTLQKLEGKCFWGKIPIDLLASSLGNCVSLSLGHTVEMSSTVEMTPSFLEPKFLEDDSCLTFCSQKVDATGSFQLQVSISAQEAGAKDMSESPYSVYSYNDVPPSSLTHIIRLRSGNVLFNYKYYNNTMQKTEVTEDFSCPFCLVPCGSFKGLGCHLNASHDLFHYEFWISEECQAVNVSLKTDSWRTELLAEGVDPRHQTFSYRSRFKKRKRVEISSDKIRHVHPHIVDSGSPEDAQAGSEDDYVQRENGSSVAHASVDPANSLHGSNLSAPTVLQFGKTRKLSVERADPRNRQLLQKRQFFHSHRAQPMALEQVFSDRDSEDEVDDDIADFEDRRMLDDFVDVTKDEKLIMHMWNSFVRKQRVLADGHIPWACEAFSQFHGQELVQNPALLWCWRFFMVKLWNHSLLDARAMNACNTILEGYLNGSSDPKKN
The following text describes a protein:
Function:
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Sequence:
MSNLLEKFKNKSKSLFFIPFFVSGFPSFDFLEVFLLKNKDKIDILELGVPFSDPVADGPVLQEINYRAMVRGVNLNSTLDWLVRSGVSRNIDVILLLYFNLIQNKLEENLKRFKDTEIKGLVIPDLPMEEAETLIPLFNKYNLDLILFISPTTRDERMKKILKMAPSFLYCISVKGVTGERDKLPEEGVSFISRIKKETDKPLVWGFGLSNSSQIAALKGLVDGVIVGSAIGKRLLNNEDIQEYFDELYRATL
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.
Subcellular Localization:
Cytoplasm.
Domain:
The PTS EIIB type-2 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain.
Sequence:
MAYLVAVTACVSGVAHTYMAAERLEKLCLLEKWGVSIETQGALGTENRLADEDIRRADVALLITDIELAGAERFEHCRYVQCSIYAFLREPQRVMSAVRKVLSAPQQTHLILE