lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism.
Sequence:
MNRLSSENNVVPIGMLRLLRGGMRRLDPSHRPVNGESCDGQPGFPPESFDAMDELKKTMEESCPRVVSCADILEMGTRDADVPELEKTLLNLQPESSIQEAIQGFAKMPEAEASSVMKRQNFPRWNFTMTWINNCFSKDRVEEIIESLASTNDEWCKETARSLRRLLPIALKQALASIRQGRTQSLKKCLEREQRITLNCLRSLVSDDLYEGIRAVVVDKDRAPKWNPSTLAEVTDDMVEMILNTYTAREQIQLPLEDEERLGEETLEDARNQNHFDGRSACISAVISEWWRMSLAAIRLQSLDGW
The following text describes a protein:
Function:
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Sequence:
MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAAVSVLGTEPNS
The following text describes a protein:
Function:
Common component of the spliceosome and rRNA processing machinery; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEQIFSLSLFDLGFRLQTGEVVNPKAYPLADSQLSITILDLIQQAANYNNNNNNNNNRISIPVTLKGINYLLWARMVKIALGGKGLWIKRAINTLNQGDMEFQPHFGKFRSLWAEMELLSPHAFTLNVPYVFVPSKQALGRACGVTRSVVACSVTSNEGSQLKSQIQQLKDAIEKLLI
The following text describes a protein:
Function:
Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.
Subcellular Localization:
Cytoplasm.
Sequence:
MKHLTQEQVNELRAILLEMRRKILESAESQLKDPSNVKFEGGDEIDRADLETERFITFRIKDREAKLLHKIDYALMKMEMGTYGICENCGAQIPFERLKARPVTTMCIECKELEEEMEND
The following text describes a protein:
Function:
DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3 (By similarity). Probable chromatin remodeling factor.
Subcellular Localization:
Nucleus.
Sequence:
MAFFRNYSNDTVSHNVLDENEERQNAATFQSSPLNEDVDGTYSERGFDMNMDVQYQSDPEPGCSIRQPNETAVDNVADPVDSHYQSSTKRLGVTGRWGSTFWKDCQPMGQREGSDPAKDSQSGYKEAYHSEDNHSNDRSEKLDSENENDNENEEEDNEMNKHQSGQADVPADEMLSDEYYEQDEDNQSDHVHYKGYSNPTNSRSLPKAGSAVHSNSRTSRAIHKNIHYSDSNHDHNGDADMDYEEEEDEDDPEDADFEPYDAADDGGASKKHGQGWDVSDEDPESDEEIDLSDYEDDYGTKKPKVRQQSKGFRKSSAGLERKSFHVSSRQKRKTSYQDDDSEEDSENDNDEGFRSLARRGTTLRQNNGRSTNTIGQSSEVRSSTRSVRKVSYVESEDSEDIDDGKNRKNQKDDIEEEDADVIEKVLWHQLKGMGEDVQTNNKSTVPVLVSQLFDTEPDWNEMEFLIKWKGQSHLHCQWKTLSDLQNLSGFKKVLNYTKKVTEEIRYRTALSREEIEVNDVSKEMDLDIIKQNSQVERIIADRISKDGLGDVVPEYLVKWQGLSYAEATWEKDVDIAFAQVAIDEYKAREVSIAVQGKMVEQQRTKGKASLRKLDEQPEWLIGGTLRDYQLEGLNFLVNSWLNDTNVILADEMGLGKTVQSVSMLGFLQNTQQIPGPFLVVVPLSTLANWAKEFRKWLPGMNIIVYVGTRASREVCQQYEFYNEKKVGRPIKFNALLTTYEVVLKDKAVLSKIKWIYLMVDEAHRLKNSEAQLYTALLEFSTKNKLLITGTPLQNSVEELWALLHFLDPGKFKNKDEFVENYKNLSSFNESELANLHLELRPHILRRVIKDVEKSLPPKIERILRVEMSPLQKQYYKWILERNFHDLNKGVRGNQVSLLNIVVELKKCCNHPFLFESADHGYGGDINDNSKLDKIILSSGKLVILDKLLVRLRETKHRVLIFSQMVRMLDILAEYLSLRGFQFQRLDGSTKAELRQQAMDHFNAPASDDFCFLLSTRAGGLGINLATADTVVIFDSDWNPQNDLQAMSRAHRIGQQEVVNIYRFVTSKSVEEEILERAKRKMVLDHLVIQKLNAEGRLEKRETKKGSNFDKNELSAILRFGAEELFKEDKNDEESKKRLLSMDIDEILERAEQVEEKHTDETEHELLGAFKVANFCNAEDDGSFWSRWIKPDSVVTAEEALAPRAARNTKSYVDPSHPDRTSKRKKKGSEPPEHTERSQKRRKTEYFVPSTPLLEGTSAQVRGWSYGNLPKRDAQRFYRTVMKFGNHNQMACIAEEVGGVVEAAPEEAQVELFDALIDGCKESVETGNFEPKGPVLDFFGVPVKANELLKRVQGLQLLSKRISRYNDPISQFRVLSYLKPSNWSKGCGWNQIDDARLLLGILYHGFGNWEKIRLDESLGLTKKIAPVELQHHETFLPRAPNLKERATALLEMELAAAGGKNTNAKASRKNSKKVKDNLINQFKAPARDRRGKSGPANVSLLSTKDGPRKTQKAEPLVKEEGEMSDDGEVYEQFKEQKWMEWCEDVLADEIKTLGRLQRLQTTSADLPKEKVLFKIRRYLEILGRRIDAIVLEHEEDLYKQDRMTMRLWNYVSTFSNLSGDRLNQIYSKLKQEKEEEEGVGPSHLNGSRNFQRQQKFKTAGNSQGSQQVHKGIDTAKFEAWKRRRRTENDVQTERPTITNSNSLGILGPGPLDRSHRARQTGFPPR
The following text describes a protein:
Function:
Hydrolyzes ribosome-free peptidyl-tRNAs (with 1 or more amino acids incorporated), which drop off the ribosome during protein synthesis, or as a result of ribosome stalling; Catalyzes the release of premature peptidyl moieties from peptidyl-tRNA molecules trapped in stalled 50S ribosomal subunits, and thus maintains levels of free tRNAs and 50S ribosomes.
Subcellular Localization:
Cytoplasm.
Sequence:
MTLLVGLGNPTLRYAHTRHNAGFDILDSLVSELDLSFTFSPKHNAFLCVYKDFIFLKPQTYMNLSGESVLSAKNFYKTKELLIVHDDLDLPLGVVRFKNGGGNGGHNGLKSIDLLCSNSYYRLRVGISKGIGVIEHVLSKFHKNEEPLKNAAFEHAKNALKFFIESHDFNAMQNRFTLKKPLKIES
The following text describes a protein:
Function:
E3 ubiquitin protein ligase that acts as a positive regulator of sugar signaling during early seedling development. Possesses E3 ligase activity in vitro.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAMRGVDFKWYDGFFLSMLATSVIIVAVNWNRYRACEYPLHIWIVVDYTTVFIFRVFMFVDNGLASGLGLDFGSQQRNAMFCGRVVVLSVLSLLLYPFLWAWTVIGTQWFTKSKTCLPEEGQKWGFLIWLMFSYCGLLCIAFICVGKWLTRRQVHLLRAQQGIPISEFGILVDMIRVPDWAFEAAGQEMRGISQDAATYHPGLYLTPAQTEAVEALIQELPKFRLKAVPDDCGECLICLEEFHIGHEVRGLPCAHNFHVECIDQWLRLNVKCPRCRCSVFPDLDLSALSNLQSSGTEQHSQVNTETSEARYIRSQPQSESYFLRVQSLIHPVHTDTALETAENGGVPPVLTDLSPSRR
The following text describes a protein:
Function:
Odorant receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKMSNFTTATEFLLMGFSDIRELQILYSFLLFLIYCAGLMGNLLIVMITTFDRRLHTPMYFFLRNLAMLDACYLSITTPQASINSLVNNRVISVAGCAAQVFLVIFLAYVELTLLTVMARDRYVAICHPLHYPVIMSPRVCMQMTLTCLLTGLVYAGFHTGYTFCLSFCQSNVVHQFFCDIPSLLRISCSDTFSNKLSLLASALVVGISCYTFITASYVRIFSTVLKFPLKEDQKKAFSTCIPHISVFSLFLISGIYVYFQPPSESGSLKDIILSVFYTVIPPFLNPIIYSLRNKQIKGAIRIFMTKALSLRNKA
The following text describes a protein:
Function:
In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
Subcellular Localization:
Nucleus.
Sequence:
MVTAIKGVLVKCDEPTMQIILMLNEEKNFLIEKISDTVCLCKENVHDFLEKEVIKQLEYSERHETED
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLQLREEIEKLRTRFGNTGSEPPNLQLSALITIAVIEALSAKKTDIQTFKYASRYLTPEVYDELVGERTYEHICGYPPCGLVPKSASGKNKILGTLAQNQKFDVPWAYLRTFCSKQHYQASQFYRAQLSSDPLDLRGSIWGDYGSCKQYEGSIILLEELTSDAQQGKSMAEIVEGFTQMSLKDPELARMNIPANGDEITKLGKEIQEISLREREDDENDVEPDYESLEDMSSKDKASAIEGYKPRIQWR
The following text describes a protein:
Function:
Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. In plasmacytoid dendritic cells, it cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA fragments and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP), a potent stimulatory ligand for TLR7. Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs.
Subcellular Localization:
Endoplasmic reticulum lumen. Lysosome lumen. Mitochondrion intermembrane space. Secreted.
Sequence:
MAEARGALPGWVSVLGWGLALCCLCGAGPLWSGSHEWKKLILTQHWPPTVCKEVNRCRDSLDYWTIHGLWPDRAEDCNHSWHFNLNEIKDLLRDMKIYWPDVIHPSSNRSQFWKHEWDKHGTCAAQVDALNSERKYFGKSLDLYKQIDLNSVLQKFEIKPSINYYQLADFKDALTRIYGVVPKIQCLMPEQGENVQTIGQIELCFTKEDFHLRNCTEPEEQPSSGQEARLAREASTHGMMVCEDGPIFYPPPKSQH
The following text describes a protein:
Function:
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).
Subcellular Localization:
Basolateral cell membrane; Single-pass type III membrane protein.
Sequence:
MGLPRAGLWLKRLWVLLQVALQVAVGKVLLTLFPDRVKQHIVAMNQKNPHFSYDNWVPTLYSTQYFWFVLKVHWQRLEDTTKRGGLAPNSPVVRLSGQRCNIWDFMQGNRPLVLNFGSYFSSIADFLIIYIEEAHASDGWAFKNNVVIRNHRNLQDRLRAARLLLDRSPPCPVVVDSMENRSSQLYAALPDRLYVLQARRILYKGKPGPWNYHPEEVRAIPQFQVTNGRALQGSARPLTQLAFTS
The following text describes a protein:
Function:
Has a function in the folding of beta-tubulin. Microtubule-associated protein that is essential to direct polarized cell growth and to position the nucleus and septum to the center of the cell during mitosis.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Microtubule-associated.
Sequence:
MEEEESLEGIISIDESLITSRLSQILDDVLDDRSSSHSVEKLKDVAVKYLQFCQFQPTLLDKLLSKYVPNLASYLLKVKNIGKCNSITVILYQFCKIRGYKAVRVLFPVGVQYIKELYTLLNESSNNTWHFHYIVLLWLSQALNTPFPLNSLDDSLDVKKTIYTIAIKYLENSGIDKEASCLVLSRLFSRDDGLDLLLGFLHHCESSWFKRSIFYKIGCLFSLSSFLKICPRNDCLQTVDVAFQFLNVAREDLVGQENSALRKLLCKCYTRLGIVLLPVNSSPNWKYSISNPDSFFQLPDDSNEEVHIYLEVIVDFLLSSVSDIDSFVRWSAAKGLAKIISRLPWNLAEQVIDAIIELMTENMFLNPIENTVNISITSPLVWHGAILFFAKLAGAGLIKYSKCLHILPLIEVGLSYEVRYGTRVTGQSIRDASCYFVWSFYHCYSKSAIEGLQTNLILCLLQTVLFDNEINVRRAATAALFEVIGRHASIPDGLSLISHINYVSVTDISNCYGDLCMKVAHFPQFRSCVFQRLFTNLQHWDVKVQQLSAFSLRQLSIKYPKELSIYLPPILDYLSVGNADFIFGYTIGLASIIGGFLSISFPFDINRIHDLLSHKNLLSLKKFSRQQQTKIILGILKGIQQIFANDIRVDRAFFSEAFSVIIAAIDLQEETIIKDISDAYSVLVKFDDMEETLEVLLDYIRKCSTSKEARIVYIILQNLPNISFRYQKKICKLLLDIYPQLHSIDYQAPVANALQNIIPFTYEKTESIEEFVKELLQVCSNYLTDTRGDVGSWIRKPAMKAISSLLVKDSSGKKLSEDIVWCCISYIIRQTFDKIDSLRGLAYQALEQIRVHYLIRRCEALTNIINRIRNNPNMDGEVLNELNISLLEIPNLRLQAFYGITVFTADGFGSDLAVKCFEFYLSYVYQLEDSFKKSNSRYGKRDLLQLYIDILSSEDEIARFYFPIMKSFTSLLAYGCFTDFQNVKGMSKAIFIVQRRALTCKSPGGLSAILELYRTLFLSKNELLRHHALKYTANLLLNPIEKVRYQAADTLLYAKSIGLLTFLPNELNQKLLTLDWFVPVSQNATFVKQLRNIIQKQIDKLIADR
The following text describes a protein:
Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. Also required for growth at normal temperatures.
Subcellular Localization:
Nucleus.
Sequence:
MIQTASTISSNGGTNQGMESSSANSPEMNGTQNSMSVGMSGSGSSQNRKITQFSNKLYNMVNDSSTDSLIRWSDRGDSFLVIGHEDFAKLVLPRYFKHNNFSSFVRQLNMYGFHKVPHIQQGVLQSDSPNELLEFANPNFQRDQPELLCLVTRKKAGSQPVEESNTSLDMSTISSELQNIRIQQMNLSNELSRIQVDNAALWQENMENRERQRRHQETIDKILRFLASVYLDGKQKPPSKVMPKSRRLLLEAKYPTVSPTNEPSAHSRPSPQGTTANSSSASISSLHNTTPDGEGKYRSVQNGRALNYVSSFNSDSHSPKDYISQSYTNEPGLKKESADSFNNSIDSYISPNQSPNTDVPSLNRDDTTDPKVVNTGDIINMLDDANSIEGSNMNSLSPLLFDYPNSLYPVNNTSSEQHHNSYRGSVSNSQPSGNLSESTNLQPVQPVDYMSNSNPSYGSYNAEDQLTNFHPGYAMDQKRISKLSDGITKQDQNIQALADILGIPLGDGKIDDAGFSANSPTNLNLPVSSDLDSVLNIPPNEDVFPDSNPVFDEFTNISNLTSPIEASNGNTFGSNPVSLPNQQKSVNPSLMTVSSPRQVRKKRKSSIGA
The following text describes a protein:
Function:
Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.
Subcellular Localization:
Cytoplasm.
Sequence:
MVATGSLSGKNPASISELLDCGYRPESLLSDFDYWDYVVPEPNLNEVIFEESTCQNLVKMLENCLSKSKQTKLGCSKVLVPEKLTQRIAQDVLRLSSTEPCGLRGCVMHVNLEIENVCKKLDRIVCDSSVVPTFELTLVFKQENCSWSSFRDFFFSRGRFSSGFRRTLILSSGFRLVKKKLYSLIGATVIEGS
The following text describes a protein:
Function:
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
MADSPGLARAHDVLRVSADNRARVDALSSAASAYVSAASPHLSPSFFEGFALRRIRVLSVHPGIIHCSYHVPPSLTDSSTGCLAAGVVVALVDEIGYAAAISHAQNFKVSVDMSVAFPDLSQARAGDRLSITARVLGHKGAYSGTHVLLTNASTGNVVAEGRHSIFGNLKKAPLKPAATTSLKSNL
The following text describes a protein:
Function:
Late secretory t-SNARE protein required for secretion and proper cytokinesis. Plays an important role in the secretion of virulence-associated extracellular enzymes and vesicle-mediated polarized hyphal growth.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MGIKKMFQKKEPTEQEIREELSRVGISTRSNNTRQEKFGAFKNYAQERANMKPQLGPVGGNPYANINPGTNNNNNNPYANDNGNNSTGNPNNNSNSNNGGNPYGGGVTNNNPYGGSGGNGRGSSPSPYAPTTSTTTRSSNPYGNNNGSRSSQNTSSPYAKSTNNSSYSNSPYSGSTVNNGNRGGHSNNSNSSAGGNPYAAGGRSSQSQNSRDNVYTAPATRTSTRQTQGYGGGDTDSTLDLNAIPSHQMFDNKKPIKRNQQSSQQPANDYNLDLNDEYGEEEDLNLDISEVPEEQQQINSEDEEVEAIKQDIKFVKQESVQSTRNTLRMAQEADASGTNTLGMLGSQSERLYNAEQNLLLAETQTQIADEKVKELKRLNRSIFIPANGNPFNKKSRLRQQEEKIKNQKLQEKYIRENNRQEMFASEQRIKQGITNNSTNNDVYNKYQDEKNLSAAKRYQFENDSEDDDMEKEIASNLNQIDQYAKKLKGLANTMGTEVDNQNTRLKKIEESADKLDINVHMNTTRLNNIR
The following text describes a protein:
Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MNVSFGLSWILRFCSLVVALRSVHGDLSYSFPEEMKREYVIGNVAKDLGINPKILSSRKARLDFEGGRRRLCDINVNTGDLITSERIDRESLCGKKPSCVVNVDLVLESPLELHRVSLHIQDVNDNSPKFRENLIQMEIRESADKGNRFSIQEAHDADIGQNAVQRYTLQKNDNFILAVDNNKVELVLENTLDREKQSDMNLLLTAVDGGSPQRSGTVIIHVTVLDANDNAPVFSQDVYKATLPENSPPETLVITVSATDADEGVNADVTYQFGHVSDDDVHVFLIDQKSGEIRLTGLIDYEEFASFEIRVEAKDGLGLTAYAKVLIDVTDVNDNNPIISLNSLSNSIPENAPPGTEVGIINVQDRDSDKNGQVRCSIQANAPFKLVPSIKNYYSVVSTGQLDRELVSDYNITISATDEGSPPLSSSKTVHLSVADINDNPPVFEEQSYSAYVSENNQAGSTLCSVSARDPDWRQNGTVIYSLLAAEVNGAPVSSYVSVNGDTGLIHAVRSFDYEQLRSFQVQVMARDNGSPPLSSNVSVSVFISDVNDNSPQILYPAPEGSSFMTELVPKAAHGGSLVSKVIAVDADSGQNAWLSYHIVKSTDPGIFTIGLHSGEIRTQRDISQSDSMKQNLIVAVKDNGQPSLSATCAMYLLISDNLAEVPELKDISYDEKNSKLTSYLIIALFCVSTFFLTFIIIILGVRFCRRRKPRLLFDGAVAIPSGYLPPNYADVDGTGTLRSAYNYDAYLTTGSRTSDFKFVSSYNDNTLPADQTLRKSPTDFLEDFDESNNSTQVGLPFFSDCSCFFLCMLSVFFATLNVLYFCPQGQNRALNYGMATFNYGPQQQSLTARTMLFSQQWKKSRGSKRPKKFLKERNKPKYT
The following text describes a protein:
Function:
Regulates secA expression by translational coupling of the secM secA operon. Ribosomes translating the C-terminal region of secM can disrupt an RNA repressor helix that normally blocks secA translation initiation, derepressing the expression of secA. Translational pausing of secM at Pro-166 under secretion-limiting conditions increases the duration of the disruption and thus increases secA expression. This is controlled by interaction of the secM signal peptide with secA and the translocon, possibly by secA pulling the paused secM out of the ribosome. The arrest sequence (150-FXXXXWIXXXXGIRAGP-166) is sufficient to cause arrest of unrelated proteins. Elongation arrest can be alleviated by mutations in the 23S rRNA or in ribosomal protein L22.
Subcellular Localization:
Cytoplasm, cytosol. Periplasm. Note=The active form is cytosolic, while the periplasmic form is rapidly degraded, mainly by the tail-specific protease.
Sequence:
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLT
The following text describes a protein:
Function:
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDPLLLIGAITAGGVLIGGGVHFVPVGGAPAAMATATGVGTGTAMLAAGAGLTGLITAAAMTGQSPLMIMAAGAVGSMLMIGITMLVGNLIYVFGVGTVPVSAKVSVDPITGMEQEKYVTPGTEGHGLPTVCFVSGIIGGALGGIGGGLIYWALNEALKTLSYGAMGAAGVAAIFAVGIFFINAVIASYNIGGTIEGFHDPKFKRIGRGIVACLIASIVAGALSTLLVYGGVF
The following text describes a protein:
Function:
Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MHHHLWTKDNSAACEEVMAALDECHARGFLWKCMGMCNDKKTAVNKCLRAQRLARTAANREAAKVKNEKIKAKWAEIDEAS
The following text describes a protein:
Function:
Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation.
Sequence:
MSTLTNNANNSSSSNNSNNNNNSSSNNTNNNNNNSIASYYQQYIQHYQVSPQGGTAPPSAGGSPTVTSINNNNNNGPTSDNIHTINNNNISTGSSSTSSNQSQPTTAASTGSGGGGGVVGGILGVREVSAKLFLPFARAKMMHSSSSAASTPAKDQHQPGTPLDGTSMAGLNATPSGTPSATPGTTTGGSSAGVSGAGRASSLIIPKALNVVLHGYHRKHKTNKKKYFVVYGDVPGKAARLEYFDSEKKFKQSFQKGSAGCDGGTQPKRTIVLRTCFNINKRHDLKKQIISLYTKDDSFCIVFESEEELNLWLRTLLRLQRGEDSEGDPPRPTFEHVWEVYVQRKGLGDSYGILGNYRLCITDKTLSLVRIGSELTPHQEKRAENVEFLLASVRRCGHSQRYFYLEVGRSSKTGAGEIWMEVQDSIIAQNMYTTIMKSAKSKDDNLGPMIRIRSSSANAASKPTSMLFRRQTHTGQKPINCSPSSVTSASATAGVVFHQRALSLPSAPMLGHSPHSNTHHLGALHAHAGGSGSSVRSSSQCSVVAAVAAGTQGGLLPSATGGSQHIVTLSTSLSSSSASCAGPGTIQPVHHRTRSLPLTEESAIRLTAEHYRQGGGGWWQPHHHAPSSLSHYNHLQQPHCSSAAGASNHRKSSSAYLPAPPPTFSSIGCSSAQCPMHAGGPNGGGGWSPPVSDVLCTSPPHRHQYELSPEGPQPFASLVPSRSSMESIIEDQRYLPMDLKKPAGEETPEPPLPPALPAGSQLTLISRLLRSSNLQQHASTSSSGSGSGSASSPGTTLSAGKIGLLGLKMAMMAEGRGSASSNGGCCSCSSPSQSQCSSGSNCLQAISSNSTTNTTTITTTTSSSHKSTNGSSPAALRRLSAGRTASGTISRSVAIARERCDSLPSRNRTTSETMPHQQQQQQQHLLNQQQQQQHHHQLMLNSGSMPPPRMIPSSNRPHSVHISHSHSPPVNSSPLSPPPPATYSTGSDGSSLSIDESTDSFITGSLTPDEGQGYPKVINQLNSGCSIPEENSEEFIKDYGHIDLSAAGCGISQHDDFAVPAARRGGSPAPPSTVGSVEGSAYMEMCSPSGSSPGDPSGSCYMAMSPVADFSRGLCSSSSAHSRASSLAEDIVDGYVPMSMPRTAAAAPAAPPTEEYMLMDPTLNGGGTSSRLSNATAASNNAGSSIIGGGGMSSAASSCSITSGTPSADLRLSLEKVPAYIGQSDEHEVNDRPFRTYSVGSRPELIKRKLRVEMLSSGESSVGGSSAGGSASSRQRAFSVGSRAKVPRCSDVYKGYSAAPVIVSFASTSSQGSMLESSNNNSSSSTSSISHAGSYGASIGDTLPMDELAGGGSAGGSSMGRKSGSGSLLPDGAGGGKPPSHGGSHGRMSDLMEIDYSSPRQQPARPSTRSSEPSGMEDYLDMSGNNNEEEQRARGQGAASSGYVEMRPGRLNSQSEENDYLNMTPGGGGRDEPDCCPVAASIATSSPIQIQHHAKQPADGADSAHSSSSNNNNNNNYLEMYPRAAVAQKEQKRTASATSTTNTATKVPSEDYLNMAPLMISSLGEASGSEEEKMHGPDEEPLLESSSAPPDGYMEMSWNHHGPVTAAGPVSSSASSSATSSARTVPTNGGDDYMNMSCGSGSQSEDASRTYSAPITIQPGAGKCRLDLSGESKVEAGANIPNYLPLGQHPDARKSVHHPHHQSAMIVALQQHLPLAAQAPIQTTTGQQSGSIGFSPSKPAETTPERARCDSRDSGIVTPSGSQPTIFPFSPASPTKPFAPAQDEPMGGESLDDLSQNYAELSLGRQQQQQLQQAQTELSPAIRKLSTGSNRGSGSFSKLQLVANQPDYVNYCPATPPISGDVAPPASNMPLNVLPSAQSRTRSSIDDDGAGDYALMNPASSRKLSTTSMGSMGGASLSPAGVVPPGSSAVGSITPPVLVARKSTLLLSSPQMGFKPIASSQDAELLLQSKAVPHATANSPKALNLGRRTGEPAFSFTEQQHQQQQMAPLQRSISTGTRPNSVNSELIGRPIGTPAGPSTPGAASHSSTTAAGSTRPSSANSERLPVISATSSSASSTSTLCESKNQSPSASSTALAMVVGSSTTTSPPSVPGSRPDSVSSITDPHIVSRPPSVSSERELHYASLDLPPCSSSGKQTVAASPFAPGTMMLLAAAAAATTPAATSSAAAPVTKMDVDEPLPGSNEARTSIDSSSPSPTTAAGLQQQQQPVRCAAFTYAQIDFVRSQAQSQQGQTGAGPAGASGQSTTTTTTSTPPQSSQA
The following text describes a protein:
Function:
Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle membrane. Apical cell membrane. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment.
Domain:
The N-terminal domain seems to play a role in the reaction cycle of the catalytic subunit such as ATP8A2.
Sequence:
MAVNYSAKEEADGHPAGGGPGGGATAGGGGAVKTRKPDNTAFKQQRLPAWQPILTAGTVLPAFFIIGLIFIPIGIGIFVTSNNIREYEIDYTGVEPSSPCNKCLNVSWDSTPPCTCTINFTLEHSFESNVFMYYGLSNFYQNHRRYVKSRDDSQLNGDNSSLLNPSKECEPYRTNEDKPIAPCGAIANSMFNDTLELYHIENDTRTAITLIKKGIAWWTDKNVKFRNPKGDGNLTALFQGTTKPVNWPKPVYMLDSEPDNNGFINEDFIVWMRTAALPTFRKLYRLIERKSNLQPTLQAGKYSLNITYNYPVHSFDGRKRMILSTISWMGGKNPFLGIAYITVGSICFFLGVVLLIIHHKYGNRNTSADIPN
The following text describes a protein:
Function:
The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSDIWDDEEVRETPSEITRVKRDHSQAGYLAGVTKAKDESLQEGFNAGYPIGGQLGLSIGRIFGYLQGKGLVEEEKQARKELSSTRIFDRQYWTTDAAPTYEGVHPLVKQWENKIDVMKRE
The following text describes a protein:
Function:
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MARCFSLVLLLTSIWTTRLLVQGSLRAEELSIQVSCRIMGITLVSKKANQQLNFTEAKEACRLLGLSLAGKDQVETALKASFETCSYGWVGDGFVVISRISPNPKCGKNGVGVLIWKVPVNRQFAAYCYNSSDTWTNSCIPEIITTKDPIFNTQTATHTTEFIVSDSTYSVASPYSTIPAPTTTPPAPASTSIPRRKKLICVTEVFMETSTMSTETEPFVENKAAFKNEAAGFGGVPTALLVLALLFFGAAAGLGFCYVKRYVKAFPFTNKNQQKEMIETIVVKEEKANDSNPNEESKKTDKNPEEPKSPSKTTVRCLEAEV
The following text describes a protein:
Function:
Probably acts on the acetaldehyde produced by the degradation of ethanolamine, producing ethanol; Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon. EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection.
Subcellular Localization:
Bacterial microcompartment.
Sequence:
MQAELQTALFQAFDTLNLQRVKTFSVPPVTLCGLGALGACGQEAQARGVSHLFVMVDSFLHQAGMTAPLARSLAMKGVAMTVWPCPPGEPCITDVCAAVAQLREAACDGVVAFGGGSVLDAAKAVALLVTNPDQTLSAMTEHSTLRPRLPLIAVPTTAGTGSETTNVTVIIDAVSGRKQVLAHASLMPDVAILDAAVTEGVPPNVTAMTGIDALTHAIEAYSALNATPFTDSLAIGAIAMIGKSLPKAVGYGHDLAARENMLLASCMAGMAFSSAGLGLCHAMAHQPGAALHIPHGQANAMLLPTVMGFNRMVCRERFSQIGRALTNKKSDDRDAIAAVCELIAEVGQSKRLADAGAKPEHYSAWAQAALEDICLRSNPRTATQAQIIDLYAAAG