lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Dehydrogenase; part of the gene cluster that mediates the biosynthesis of aspernidine A, a prenylated isoindolinone. The starting point of the biosynthesis of aspernidin A is the production of orsellinaldehyde by the non-reducing polyketide synthase pkfA. Hydroxylation, methylation of one of the phenol groups, and prenylation, presumably catalyzed by the prenyltransferase pkfE, would be needed to yield aspernidine D (Probable). Subsequently, the cytochrome P450 monooxygenase pkfB is responsible for hydroxylation of aspernidine D to yield aspernidine E. The dehydrogenase pkfF may be responsible for further oxidation of aspernidine E to form a dialdehyde intermediate which is further transformed in a series of steps, some of which are enzyme-mediated, to generate aspernidine A (Probable). The possibility that additional enzymes outside of the cluster are involved in aspernidine A biosynthesis cannot be excluded (Probable).
Sequence:
MRHTALLPLVSSFIVPALAQIPGQTTVNATVNQGRFGNATYDYVIVGGGTSGLAIAARLAEDPSLSVAVIEAGGYYELDGTVASIIPGLAAGANVGTDATEYSTVDWNFQAQPLTSANDRSLRYNRGKTLGGSSARHYMVYQRGTRGSYDQWAELTGDESWGWDSVFPYFQRSVNVTPANMTGRFPNTTVTYDPSGFNKAGGPLHVTWPNYGSPWSTWIEQGLEAIGILPDTDFNTGTLNGSSWAPITINPLSQKRDSSETSFLQQSLKTTNLTVYLHTMALKIGFDGTTASSVDVRSPVGRFTLSARREIIVSAGALQSPQLLMVSGIGPRETLERHGIPVVKELAGVGQKMWEHPFFGITHQVNLVTATELAINQQALLQALNQYKSQQGPLTSAGFGVLGWEKLPNSTLSDSTNEALATFPSDWPTIEYLSIDGYLNGWHSAADQATGNGQQWGTIAVALVAPLSRGNVTISSSDMDDPPVFDLGFLTHPADREIAVAAMRRIRQAFAAISEITIGDEVVPGADVSTDEELLDFIRESIVPVYHVAGTCAMGREDDPEAVVDPQARVIGVNNLRVVDASIFPTLPPGHPQSTCYMVAEKIADLIKKGN
The following text describes a protein:
Function:
Binds to platinated DNA and confers sensitivity to the anticancer drug cisplatin. Activate the expression of the COX5B gene.
Subcellular Localization:
Nucleus.
Sequence:
MNTGISPKQDDASNSNLLNIGQDHSLQYQGLEHNDSQYRDASHQTPHQYLNQFQAQPQQQQQQQQQQQQQQQQAPYQGHFQQSPQQQQQNVYYPLPPQSLTQPTSQSQQQQQQQQQQQYANSNSNSNNNVNVNALPQDFGYMQQTGSGQNYPTINQQQFSEFYNSFLSHLTQKQTNPSVTGTGASSNNNSNNNNVSSGNNSTSSNPAQLAASQLNPATAAAAAANNAAGPASYLSQLPQVQRYYPNNMNALSSLLDPSSAGNAAGNANTATHPGLLPPNLQPQLTHHQQQMQQQLQLQQQQQLQQQQQLQQQHQLQQQQQLQQQHHHLQQQQQQQQHPVVKKLSSTQSRIERRKQLKKQGPKRPSSAYFLFSMSIRNELLQQFPEAKVPELSKLASARWKELTDDQKKPFYEEFRTNWEKYRVVRDAYEKTLPPKRPSGPFIQFTQEIRPTVVKENPDKGLIEITKIIGERWRELDPAKKAEYTETYKKRLKEWESCYPDENDPNGNPTGHSHKAMNMNLNMDTKIMENQDSIEHITANAIDSVTGSNSNSTNPNTPVSPPISLQQQPLQQQQQQQQQQQHMLLADPTTNGSIIKNE
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAPISKEARVQPSKASGGIPNPTSEYLEKTYTKPNQGPTPSLLARHLLVVIDLNGTLLYRPNRKNPTKFTARPHAEKFLQYCVDTFSVIIWSSAKSQNVIPMCQTILTPKLRQKVIAIWGRETFGLTGQDYNMRVQCYKRLTKLWGDPKIAASHPDTQNGGRWDQTNTVLIDDSSEKARSEPYNLIEIPEFFGDDKEVGDVLPQVHDYLNFLSMHENVSATIRHSPFVPLPKANPHEATGLNLPIHPPRVPGPARVPSPVVEPVYKPSHSGDTIPSKYQPMLGNSDKW
The following text describes a protein:
Function:
Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (By similarity).
Subcellular Localization:
Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus (By similarity).
Sequence:
MSNPSPQVPEEEASTSVCRPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLDVDAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPLLSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEDDASKEREWRQKLQGELEDEWQEVMGRFEGDASHETQEPESFSAWSDRLAREHAQKYQQQQREAEGSCRPPRAEGSSQSWRQQEEEQRLFRERARAKEEELRESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDVPWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHPDRFLQRFRSQIETWELGRVMGAVTALSQALNRHAEALK
The following text describes a protein:
Function:
Activates HIS4 transcription only in combination with PHO2/BAS2. BAS1 is also involved in the regulation of the purine biosynthesis pathway.
Miscellaneous:
MISCELLANEOUS: Present with 861 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSNISTKDIRKSKPKRGSGFDLLEVTESLGYQTHRKNGRNSWSKDDDNMLRSLVNESAKELGYENGLEDVKTIQQSNHLSKCIAWDVLATRFKHTVRTSKDVRKRWTGSLDPNLKKGKWTQEEDEQLLKAYEEHGPHWLSISMDIPGRTEDQCAKRYIEVLGPGSKGRLREWTLEEDLNLISKVKAYGTKWRKISSEMEFRPSLTCRNRWRKIITMVVRGQASEVITKAIKENKNIDMTDGKLRQHPIADSDIRSDSTPNKEEQLQLSQQNNPSLIKQDILNVKENESSKLPRLKDNDGPILNDSKPQALPPLKEISAPPPIRMTQVGQTHTSGSIRSKVSLPIEGLSQMNKQSPGGISDSPQTSLPPAFNPASLDEHMMNSNSISDSPKHAYSTVKTREPNSSSTQWKFTLKDGQGLSISNGTIDSTKLVKELVDQAKKYSLKISIHQHIHNHYVTSTDHPVSSNTGLSNIGNINGNPLLMDSFPHMGRQLGNGLPGLNSNSDTFNPEYRTSLDNMDSDFLSRTPNYNAFSLEATSHNPADNANELGSQSNRETNSPSVFYPQANTLIPTNSTATNNEIIQGNVSANSMSPNFNGTNGKAPSSTASYTTSGSEMPPDVGPNRIAHFNYLPPTIRPHLGSSDATRGADLNKLLNPSPNSVRSNGSKTKKKEKRKSESSQHHSSSSVTTNKFNHIDQSEISRTTSRSDTPLRDEDGLDFWETLRSLATTNPNPPVEKSAENDGAKPQVVHQGIGSHTEDSSLGSHSGGYDFFNELLDKKADTLHNEAKKTSEHDMTSGGSTDNGSVLPLNPS
The following text describes a protein:
Function:
Catalyzes the attachment of glycine to tRNA(Gly).
Subcellular Localization:
Cytoplasm.
Sequence:
MDALVSLCKRRGFLFQSSEIYGGVQGFWDYGPLGVELKRNLKDAWWHDMISGHNELVSPAGAPSTFEMVGLDCTIIMHPQVWKCSGHYDLFHDHMVDCRESKKRYRFDQVRGRFVEYQGTKIFVSTLAEIEQEEDEVRRRGMKFFKLRPKNADELTVEKESLTLDKLDSTDNVLAPDAKTLGTLTEPREFNLMFKTTLGALGGEEDTTFLRPETAQGIFVNFKNVVDSSRVRIPFGIGQVGKSFRNEITPRNFTFRSREFEQMEIEFFCHPNQSQEWYRYWRDRRMAWYTKLGLSNESLIMREHHTEELAHYSVGTADIEYAFPFLPEGEYGELEGIAHRGDFDLRSHMEGKLDPATNPMTVELNEHGKPKHRGSGKDLAYRDDITNEKFVPHVIEPSAGADRAALAFLCEAYTEDEAPDENGKMQTRTVMKLDPRLAPIKAAVFPLVKKDGMPEVAQEIYGALKEHYNVFYDAKGAVGRRYRRQDEAGTPYCITVDGDSLTDKTVTIRDRDTLEQTRVKIDDVVSEIQSRMKAST
The following text describes a protein:
Function:
Regulator of biological processes that recruits a histone deacetylase to control gene transcription. May play a role in the entry into mitosis, negatively regulating the cell proliferation. Formation of stable complexes with geminiviridae replication-associated proteins may create a cellular environment which favors viral DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MTRAALEKTEDAKPLDATSSISRTCSCNMDRPEARFTNFCEMGLSLDENTCTIAMKLFKETKHLLLANSSAIGNGTPDEAERFWFAFVLYAVKRLSVNNGDSEQQGCDDNGFTLCQILRVAKLTIVDFFRELPHFVVKAGPILSNLYGEDWENRLEAKELQANFAHLNLLSKHYGRAYRDFFLTSDANVDKQSSVASSSGYVSDYHRFGWLLFLALRVHVFSRCKDLVTCTNGLVSVLAILIIHVPVRFRNFNINDSQRFVKKDGKGVDIVSSLCNIFYTSEDELRKTMEKANNIIADILKKTPFPASECNSENMENIDTDGLTYFEDLLEDSSLTSSLGILEKDYDDAIRRKGELDERVFINVEDSILVSGSLSGGAVNISGVKRKFDAIASPAKTVTSPLSPQCSPGPHANGVHGGSNFKVAATPVSTAMTTAKWLRTVISPLPSKPSAELRHFLSSCDRDVTDDVVRRAHIILQAIFPNGGLGERCATGNLQSTNLMDNIWAEQRNLEAQKLYYRVLEAMCRAEAQILHATNLTSLLTNERFHRCMLACSAELVLATHKTVTMLFPAVLERTGITAFDLSKVIESFIRHEESLPRELRRHLNSLEERLLESMVWEKGSSMYNSLIVARPSLSAEINRLGLLAEPMPSLDAIAMHHNFSCGGVPPMPSLQKHETLPGQHGDIRSPKRLCMDYRSVLVERKSFTSPVKDRLLSNLKSKLPPPALQSAFASHSLTWASTWDIHVCSPTRPNPGGGGETCAETGISIFFGKITKLAAVRINGMVERLQLSQQIRENVYCLFQQILSQRTPLFFNRHIDQIVLCCFYGVAKISQLTLTFKEIIHNYRKQPQCKPQVFRSVFVDWSSARRNGEHVDIITFYNEIFIPAVKPLLVELGPAGTTTKTNRVPEVNNNTDAQCPASPKISPFPSLPDMSPKKVSAAHNVYVSPLRSSKVLDSGKTIGSAKMCSGLYLLEKDALISHNSKGYYACVGVSTHAYQSPSKDLSAINNRLNGTRKLRGTLNFDDVDVGLVSDSMVANSLYLQNGSCASTSGAPLKSEQPDS
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MAGADLTGLVDDFYFSALTHAQNDADAGEDDELFPISDEKYAAELQLQEVIMSSAIAAAATSARSSFPARRSIATTSSSAVVMYGECSSAIASSSSCSGQPGSSASASATVTATLVFCKICMDAVPESDAHRASRGCAHAFCSACLAGYIGAKIQDRIADVKCPEERCAGVLDPALCQGMLPREVFERWGAALCESMMLGAKRIYCPFKDCSAMMVADDDGGDVTQSECQVCRRLFCARCAVPWHAGADCAAYRKLGRGDRGKEDMLLLETAKRKNWKRCPKCEFFVEKTDGCLHITCRCSFEFCYGCGGQWGVTHASCSTA
The following text describes a protein:
Function:
Odorant receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
METISCNGSGDSSTTFYLMGIPSLPKSLFLPIFFVFLLLYVLILMGNTFILVAVVAKPSLHKPMYFFLINLSTLDILVTTTTVPKMLSLFLLGDSFLSFPACFLQMYLFHSFSSSEAFILVVMAYDRYVAICRPLHYPVLMTPQTNTVLTTSAWLTALLLPIPAVVQTSQMAFDIIVHIYHCFCDHLAVVQTFMGFCITMVVSFLPLLLVLLSYAHILTSVLCINSQEGRSKAFSTCSSHLLVVGTYYSSIAIAYVAYRADLPLDFHVMGNVVYAILTPVLNPVIYKLRNKDVKAAITKIACPQEPKNARKP
The following text describes a protein:
Function:
May function as a transcriptional regulator that controls feoABC expression.
Sequence:
MASLIQVRDLLALRGRMEAAQISQTLNTPQPMINAMLQQLESMGKAVRIQEEPDGCLSGSCKSCPEGKACLREWWALR
The following text describes a protein:
Function:
Catalyzes the NADH-dependent reduction of the oxo group at C3 of 3-dehydro-D-glucosides leading to D-glucosides. Probably functions in a metabolic pathway that transforms D-gulosides to D-glucosides. Can use 3-dehydro-D-glucose, methyl alpha-3-dehydro-D-glucoside and methyl beta-3-dehydro-D-glucoside as substrates in vitro. However, the actual specific physiological substrates for this metabolic pathway are unknown. To a lesser extent, is also able to catalyze the reverse reactions, i.e. the NAD(+)-dependent oxidation of the hydroxyl group at C3 of D-glucosides leading to 3-dehydro-D-glucosides. Cannot act on UDP-glucose, UDP-N-acetyl-D-glucosamine, D-glucosamine, N-acetyl-D-glucosamine, or UDP-D-galactose.
Sequence:
MKSAMTSSPLRVAIIGAGQVADKVHASYYCTRNDLELVAVCDSRLSQAQALAEKYGNASVWDDPQAMLLAVKPDVVSVCSPNRFHYEHTLMALEAGCHVMCEKPPAMTPEQAREMCDTARKLGKVLAYDFHHRFALDTQQLREQVTNGVLGEIYVTTARALRRCGVPGWGVFTNKELQGGGPLIDIGIHMLDAAMYVLGFPAVKSVNAHSFQKIGTQKSCGQFGEWDPATYSVEDSLFGTIEFHNGGILWLETSFALNIREQSIMNVSFCGDKAGATLFPAHIYTDNNGELMTLMQREIADDNRHLRSMEAFINHVQGKPVMIADAEQGYIIQQLVAALYQSAETGTRVEL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes. Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates 'Lys-6'-linked ubiquitination of target proteins, leading to their degradation. Mediates ubiquitination of EEF1A1/eEF1A and ETF1/eRF1 translation factors on stalled ribosomes, leading to their degradation. Also catalyzes ubiquitination of ribosomal proteins RPL0, RPL1, RPL12, RPS13 and RPS17. Specifically required to resolve RNA-protein cross-links caused by reactive aldehydes, which trigger translation stress by stalling ribosomes: acts by catalying 'Lys-6'-linked ubiquitination of RNA-protein cross-links, leading to their removal by the ATP-dependent unfoldase VCP and subsequent degradation by the proteasome. Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interaction with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4). May also play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway; Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
Sequence:
MSSEDREAQEDELLALASIYDGDEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNECLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGSVVLFAWMQFLKEETLAYLNIVSPFELKIGSQKKVQRRTAQASPNTELDFGGAAGSDVDQEEIVDERAVQDVESLSNLIQEILDFDQAQQIKCFNSKLFLCSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQVQCLNCPEPKCPSVATPGQVKELVEAELFARYDRLLLQSSLDLMADVVYCPRPCCQLPVMQEPGCTMGICSSCNFAFCTLCRLTYHGVSPCKVTAEKLMDLRNEYLQADEANKRLLDQRYGKRVIQKALEEMESKEWLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWICMGSLSRANPYKHFNDPGSPCFNRLFYAVDVDDDIWEDEVED
The following text describes a protein:
Function:
Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.
Subcellular Localization:
Cytoplasm, cytoskeleton. Membrane.
Sequence:
MSVGQFIHILSSRLRLTPGKALFIFVKNTLPQTASLMTSIYQTYKEEDGFLYMCYSSEKTFG
The following text describes a protein:
Function:
Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPPATGGGLAESELRPRRGRCGPQAARAAGRDVAAEAVARSPKRPAWGSRRFEAVGWWALLALVTLLSFATRFHRLDEPPHICWDETHFGKMGSYYINRTFFFDVHPPLGKMLIGLAGYLSGYDGTFLFQKPGDKYEHHSYMGMRGFCAFLGSWLVPFAYLTVLDLSKSLSAALLTAALLTFDTGCLTLSQYILLDPILMFFIMAAMLSMVKYNSCADRPFSAPWWFWLSLTGVSLAGALGVKFVGLFIILQVGLNTIADLWYLFGDLSLSLVTVGKHLTARVLCLIVLPLALYTATFAVHFMVLSKSGPGDGFFSSAFQARLSGNNLHNASIPEHLAYGSVITVKNLRMAIGYLHSHRHLYPEGIGARQQQVTTYLHKDYNNLWIIKKHNTNSDPLDPSFPVEFVRHGDIIRLEHKETSRNLHSHYHEAPMTRKHYQVTGYGINGTGDSNDFWRIEVVNRKFGNRIKVLRSRIRFIHLVTGCVLGSSGKVLPKWGWEQLEVTCTPYLKETLNSIWNVEDHINPKLPNISLDVLQPSFPEILLESHMVMIRGNSGLKPKDNEFTSKPWHWPINYQGLRFSGVNDTDFRVYLLGNPVVWWLNLLSIALYLLSGSIIAVAMQRGARLPAEVAGNNPQVPSAVLNTLLPPNNTRALAIMTPILWIRKPRNHEIKKLAPGHTARLSQVLLRGGGQVLLGWTLHYFPFFLMGRVLYFHHYFPAMLFSSMLTGILWDTLLRLCAWGLASWPLARGIHVAGILSLLLGTAYSFYLFHPLAYGMVGPLAQDPQSPMAGLRWLDSWDF
The following text describes a protein:
Function:
Transmembrane transporter that exports citrate across the cell membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSTTSSSRSDLEKVPVPQVTPRDSDSDKGSLSPEPSTLEAQSSEKPPHHIFTRSRKLQMVCIVSLAAIFSPLSSNIYFPALDDVSKSLNISMSLATLTITVYMIVQGLAPSFWGSMSDATGRRPVFIGTFIVYLVANIALAESKNYGELMAFRALQAAGSAATISIGAGVIGDITNSEERGSLVGIFGGVRMLGQGIGPVFGGIFTQYLGYRSIFWFLTIAGGVSLLSILVLLPETLRPIAGNGTVKLNGIHKPFIYTITGQTGVVEGAQPEAKKTKTSWKSVFAPLTFLVEKDVFITLFFGSIVYTVWSMVTSSTTDLFSEVYGLSSLDIGLTFLGNGFGCMSGSYLVGYLMDYNHRLTEREYCEKHGYPAGTRVNLKSHPDFPIEVARMRNTWWVIAIFIVTVALYGVSLRTHLAVPIILQYFIAFCSTGLFTINSALVIDLYPGASASATAVNNLMRCLLGAGGVAIVQPILDALKPDYTFLLLAGITLVMTPLLYVEDRWGPGWRHARERRLKAKANGN
The following text describes a protein:
Function:
Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.
Subcellular Localization:
Cell membrane, sarcolemma, T-tubule. Endoplasmic reticulum membrane; Single-pass type III membrane protein. Preautophagosomal structure membrane; Single-pass type III membrane protein.
Sequence:
MARDRGPPVLWQSPASPRLPAAALPAEARGWGWLGAGLWPALVVGLLAALVAWFWYGGSDGQGEESGEAEATENLLVSSEEVLRQAKTTALSSPQKPGEDLTAAPGSELNHILSGTVSSKSPEMEQLLPKQCVTSSETDAGQCLADACDGQGGELRPQVGQAGEGWCVMNLAGASGEVCKDRSEEQLCQPAESRDLDHEDWEVVSEHLDWGEAGQNGSMEDSDSKEWEQGDCSDGDLKAKRVAAVPPMFQNIHVTFRVHYITHSGAQLIGVTGDHECLGQWHSYVPLKYDKDGFWSESVTLPVDTKVEWKFILVENGKVTRWEECSNRTLVTEHEDQIAHQWWGYH
The following text describes a protein:
Function:
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
Sequence:
MRIVFVGTPEFAAEILEHLIKNGFNVVGVVTQPDKPRGRGRKVAPTPVKAVAEKHEVPFIQPESINKKEALEFLRSVRPDVIIVASYGKILGEKVLSLPRLGCYNIHPSLLPKYRGASPIQRVLENGEERTGVTIYKMVKELDAGPIALQKEISVDPFETFDQLEKRLIELSKEMLIEFLEKLKTGNIELKEQDHSRATYAPMIKKEDLIVDFSKDAESVKNKIRAYDSRPGARAFLGNVEVKLFGVTAIDSSGDEPGLINYIDREGAWIGTGDGKVKVRYIQFPGKKKMTFWEAKNGRLIIEGMRFERRYES
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSALDLWRSQTMRLVAFTVSREIAPSVVEEMMALGCMHFVDACSDVSFFDRAYTANIMQLATTESKLDYIRDQFIALEIPLPEQEDRVELMPLGNLDAELTATMKTVKTLLDEYQQHLADLSANLTYSQVLDIVRRESASSAQNKMLRDVLSENTHLIGSSPDDEAQETDTSANLYFLACTVPDSVTPMLQRLATRATLSNCMIEVVGKISTPDLAALIGADQSPSKPASPKKAKHKAAKDQQEYDVVFVYTPGVQLQSKVGSIVTSLSGTIHISQGVQGGGAVDSVQSLDSDVSRVQQSIEDHRTLLRLSKQRITTILNQLGAQLEAYYRLILKEKEVMGVLNKLRPSLADAKILTGIAWIPEQTFSDVTQIVEACNERYKGMLPSFIKDLNALSKTRKNGTSVLINTDDLRPATVDALHHSPKEHLRQPPTYFKTGKFTKVFQNIIESYGIPSYKEINPAFFYLYQFPFTFAVMYGDIGHGIILTIVSALMVGYERRLGKVKNDMVSLIFAGRYIILLMSIFSIFTGLIYNDMFALAYDFFHSRYTFNRSSTTPNLFESTYDTTKYSSPVYAFGIDPAWRWSDNSMMFINSYKMKMAVIIGILQMIFGIVLKLLNVIYSRDIVGLLTCWIPEFLFMTCFFGYMVFCIIYKWLNEWPEGSNPPALTSLLIQMFLSPGSISPESYLFNNIPLQTNLQLALFAICIISVLWLAVAKPVYEVVQLKKAAKKGLAHGVPIFSGQAASHEAAPITSEADLAKADTDDAQTDKTNLLVSDGKDAQGRGSSRKADQDDDDEAHGVGDIVVHQVIHTIEYVLGAISHTASYLRLWALSLAHAQLSEVFYEQLFTLSYGFSVSENKWLSGVVQGVSFFVTYSAWFGVTIGVIILMEALSAFLHGLRLAWIEFNSKFYQAEGYIFEPLAPVEYTLSLEKQDE
The following text describes a protein:
Function:
Damages membranes of susceptible bacteria. Has no hemolytic activity. Not toxic to mice. Does not inhibit the proteinases elastase and cathepsin G.
Subcellular Localization:
Secreted.
Sequence:
MLLGTTSAQVVRPGSCPNVDVPIPPLGLCRTTCQTDANCQEGRKCCKNGCGFMTCETARF
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPDPKLQSYIAAHYLSGPKADAILARASSSDIKVKRKKKKVKTDDASRVSSSSGLVFKDDSDTWKTPAEDDEDDGGLTPQVVDGADGQSLNKTFRKIGSASHGAKEAGTSDTASMSTPTPAPTSVEEPTEFKAGLRTRDEMKAARLAREERKKREAASLSVDVSMASSTPAANDDDDQEARLAQQTVYRDSSGRIIDLNAQQAEQERLERLRLEKQAERNTWSQGLVQKQQRQQAAAQLAAVQQQGIARRATDNEYNEYFKQQQRVDDPAMAFLTKKRSAGPSMPKYKGGWPPNRFNIPPGYRWDGVDRGNGYEKAFFERKAQLETRELQARAWGQSDM
The following text describes a protein:
Function:
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Prevacuolar compartment membrane; Multi-pass membrane protein. Note=Cycles between the Golgi apparatus and the prevacuolar compartment.
Sequence:
MRVRGALQAAALLASALWAAPLLAKDHPTFKTTKLDTQPNNLNYFEGSDTILFHDTHKSNLWRSDDAGATWSVVKDIPDGKVARLYMHDFDSKRAFAITDGRKHYRTTDQGKTWKTFEVDAAWDTERFDILHFHATDPDRIIFNGLHCLGFLCEEVSLYTIDDFETPAKPLRPDTLGCWWAKSSPVFTTGDSDLDKDRILCIIMGVDSIFSEDRRLVISDDFFKADKEGNIQEFEPNLAGDKPVRGVVNVAAVKRYFMVATTSANTDEMALFISTDTKKWQRAMFPNAHDDHDHKIVQEAYTVLESTNYSIQLNVMTGSKSAPMGIMFTSNYDGTYFSENLEYTNLNMFGHVDFEKIAGIQGIFLVNKVDNGKEVDEKPSTKKKLVSEITFDDGRTFDKVTADGKRIHLHSVTELNNVGRVFSSPAPGLVMANGNTGDYLGDYWEDANLYVSDDAGKTWKKALKGPHKYEFGDQGSILVAVRDSKEEDISEISYSLDHGENWVDEKLPDDLKIQPWILTTTPDSTGLQFVLIGKAKGAWHVIHIDFEGLHEATCKESDMEEWHARVDKDGEPTCIMGHTQTYPRRKKDAKCFLKKEFKLAEVETKDCDCTDQDYECDYNFERNDKGICVSRGPIPIPEGACKEGDRNGKFLGTSGYRKIPGNTCKDTKETKDKYKDVERSCGDGIGAPPDEATGELQQVDTKGKFGHWTHWEKHYLERGESSSDSSETIIMRGMNRTVDDSGPKVGPIWRTTDHGKKWDKVDFFKDDEVISIVPHPTVKDWVFFLTEGKKLIYTPDRGKRFRTFEVPQPADFEAAANGIFPLIFHPDKPNWLIWLGKKCESKNDCYRVAYGTKDGERWETLARDVYRCEFTGAEAYGRKYANRALEQILCLKHEKEGDNDSALQLVSSNDWFNQDERVRLKEAKEFATMAEFIVVATEDTEKKTLRAYASLDGSLYSEAKFPFGFEVPHQHAYTVLDSSTHAVNLFVATRMEGDKSLGTILKSNSNGTSYVVSVKNVNCDQYFYVDFEKMVGLEGVALVNVVVNPDAKSSAPKKLQTKITHNDGAQWAYLPTPRKDEFGKFPCSSSGTEKCALHIQGYTQRRDRGKTYSSEGAVGVMFGWGNVGDSLGSIKDADTFMTTDAGITWKRVKKGRWNWALGDQGSIIVLVPIRGQKTDTLEYSLDQGATWKKHTFSKEKVDIWDLTTTRSGNSQNFLIWGENSDGLFTTKIDFTKFTDHVCKYDPENLSKSDYQIFSPKHPLQPDGCLFGHVSQYLRKKPGLKCFNDFRLDPLYSKQNCTCTRSDFECDFNYELDKHGQCSLVSGLKPKDHKLWCKEHPDEIEYYEPTGFRRIPLTTCQGGLDFEKAAAVHPCPGHEDDFERKHRVSGIAIFFAVVLPVAAASAIGWWVYRHWDGKFGQIRLGEQGASTMEFFDADRPWVKYPVIALSAVVALAGAMPLVLGALWRTAKSTAERWGIGGGGGGRGGWSRLDGGGASRTFRTRDSFARGRGDYTIVDEDEGELLGEESDEEV
The following text describes a protein:
Function:
Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14 (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Sequence:
MRRRATILADLQQHGDKISFKPGDNNKSKLTVSVNAPRQDRFSAPVSNADLDVLNHVADVSVAWGRPSAAQQPVLFAAAYEPGLHVTVVKKQASEPRKWGEEKPSEAAPELVHVAKFLEEQLGLPVDPKTFIESRSDYTYYDPLVGPEAFGHFVDKHSACSDESEEFVNDLDTFNYAQSASFHIDHDKKELVTEVTIPDLEHYFNQKKQHISRACKNDRLEVGIFDLNNLATSYAFRGVAELKGLLHDSTKEKPQETFLVIEPRHNIGAGSVSVDFERPVGLHPKSELKLRHIAIPTDHNDENDGVKHCRLFAKYSAPSSIFFDKYQLADLERTTSEHPNGQGRLLALWGEADLEEPRYHTEGWGSEALVEIFPITDAPEGTPFNLNFTLPLHLRYEEPKEGETYEPNEAPWPLVFWVCAETDEQLANFKQSPFDVTHNSYMRLFPEGVSYHHIGPREANGRGFPLLSTSWGTPVADIDRFAAVRDYTSIMMVAGFLMVTIAILRKVFRGKAMSEELKEKKEQ
The following text describes a protein:
Function:
Required for the transduction of auxin and abscisic acid (ABA) signaling pathways. Dephosphorylates and inactivates the MAP kinase MPK12.
Subcellular Localization:
Nucleus.
Sequence:
MRKRERENPCSICGHYHKYEEGEVCGVCGHCMPVSSDTVAPQQVHVSAFPSEILPEFLYLGSYDNASRSELLKTQGISRVLNTVPMCQNLYRNSFTYHGLDNEKVLQFDDAIKFLDQCEKDKARVLVHCMSGKSRSPAVVVAYLMKRKGWRLAESHQWVKQRRPSTDISPEFYQQLQEFEQGIFGSEMMSAMNINDAPTFGFGFPKIDNQAQAPVFNNAPTSSIFSSPASSIPPQEFTFGATPPKPTTGGDIAMDGS
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MFVKFERHSDRVKSVSFHPHRPWVLSALHSGIIELIDYRIKKRIATYDDHKGAVRSVQFHPQLNLFCSGGDDFTVRVWNFKQCQFILKGHLDYVRCVTFHPINPWVLSGSDDQTARVWNYQSRQTIGILTGHTHYIMACHFHPTQDFIITCSLDQTARLWNYGVLKQRYAQKKNQEYVLSGAEVQLISILDAHKDQLNWCAFHQTEPFVITSADDKNIKLWKYNDTKAWEYDTLSGHTNNVCCSEFHPKGNVIISDSEDHTVRIWDFATRKQIGVYENKYFDRYWIVSCHQNNYYFACGSDTMLQVFTLHKDRVPLVLVNDRYLCIAEQKTLKVVELISGQQQIIRDIATVITPTPTLLEDNIEFIEYNTYDTQKTQLMIRCIRSFKEPSKPKRHLLIVFQQQKGDSGVKQFFANCACFIGKNKIARINQDQQVESYNYETDAVQLIDDKPASKVFHAPGGKILIQRIGTTPQLELFDPMTKQVLHSVDYLNAKYVLYVESYLIVSTKLFLSIFSKQLQKLIEIKEQINIKSFIWFNNIIIYTTKSQIKYFLLNGDTGVLKSTENILYLAKAEEQQQNKLKLIAFDNTGKYISEILDISEPLFKIAIMNKDLNSIHKFIENNQNEAMLSYLYQKKLASMALKLVKDKHAKFSLSLDCGNLEYAYKVAQVIKDPQYFEQLRTEALRQGNHLLVDVCDQQLSQFDRLFFLCLCTGNTEKQEKLQNISPNFIYESQKYKKIAIKNSLPKLSQIMDHIDGTPQKLDDGQKETIEWIKSLGGSQALVPPIPIMKFKSDPWPLVQLNEQDIINLEVTNETVVQQDIFTLQKQVIEEPQIDEQVNDGQWGLDEEPEELIIESKAKDPVNKNIDEEALRGRYVNQKGDVAIKYIVAGDYETGIKLLNQQINLNNNQQFLKLLVDLPNFQLVNSTPYLALATLPVKINRFNEIKNLIKLGYKYTTDAKFNEVSTCFQSVLQKILLTDFEENQIEDIKRYISICRSYLLAMRCDSLKKESNALEMACKMATIDLQPGHRILTLRQALSISYKQKNFITCQQIAKKLIELLKSDNTQKPEVLQNAQKYEKASQQQNSNAVQIEFQEQWLNQQPMYSANTLKNISTFKSCPYDGSVYETDYQQTCLICGLCRVGNAPGLKYQ
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MFKVIFTDKDESCITKWKVKEGGRCSSNAVLCEYKNPKSSKSLKIMSEFPGSIEKILKKENESVRYGDVLALVESCKHETVWRNMCADCGTDLNEKKTISSAFVAMEHTIPDLLVSEKSAHELGKVDERRLLKNRRLVLLVDLDQTIIHTTNDNIPPNLKDVYHFQLNHGPNNKLWWYHTKFRPYTKKFLDKISKYYELHICTFGIRPYAHAIVNLLDPDKKYFQNRILSRDECFHASLKTLNLKALFPCGDSMVCIIDDREDVWGSAPNMIRVKPYIFFQGTADINAPPELSKSSSNRRSKIAPISRKEKIIKVPILPKDEANVPDTNKNANKIVQDVKKDDDCMAEDDGVVINTKSESASNKNVDSETDVTKTNVDSKENSDKVQCSYREIVEWEDEDDYLLHLQTILLRIHEEFYKSYDAATKTDASSSGLNLKELIPLEKKKVLKGCNILFSGILPLNQSIEVSWVYVMATNFGASVQKDFAEGRNRTTHVIAAKEGTEKVRKALERGIHVVNVNWLFQCTERWERVDEALFPLSDAKNFSQKFFQVNDNLKSKDDVKVKPIQVKTNMEMLTETEKDAMLDEIDDYLNDDNEDDENDDDDKEKDDDAAKEDDDDNNNKKDNSNGASKNVNSLLGSGSKDIKEEEEDLEEKLADEKLKRKVLKCFDSRDDCSSSSDSYDNEYSNEDRLHVNKKCKFELESEGNISQIGEVSSDDSFFGNISDSDSDDVVNEDLT