lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, suppressing microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome (By similarity).
Subcellular Localization:
Nucleus matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase.
Sequence:
MISSTSVYGLKMQWTPEHAQWPEQHFDITSTTRSPAHKVEAYRGHLQRTYQYAWANDDISALTASNLLKKYAEKYSGILEGPVDRPVLSNYSDTPSGLVNGRKNDSEPWQPSLNSEAVYPMNCVPDVITASKAGVSSALPPVDVSASIGSSPGVASNLTEPSYSSSTCGSHTVPSLHAGLPSQEYAPGYNGSYLHSTYSSQATPALPSPHPSPLHSSGLLQPPPPPPPPPALVPGYNGTSNLSSYSYPSASYPPQTAVGSGYSPGGAPPPPSAYLPSGIPAPTPLPPTTVPGYTYQGHGLTPIAPSALTNNSASSLKRKAFYMAGQGDMDSSYGNYSYGQQRSTQSPMYRMPDNSISNSNRGNGFDRNAETSSLAFKPTKQLMPSEQQRKFSSQSSRALTPPSYSTAKNSLGSRSSESFGKYTSPVMSEHGDDHRQLLAHPIQGPGLRAATSSNHSVDEQLKNTDTHLIDLVTNEIITQGPPVDWSDIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWIGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVSEEHSPVSRMRTEFLMQLDTVLTSAEDQIVVICATSKPEEIDESLRRYFMKRLLIPLPDSTARHQIIVQLLTQHNYCLNDKEFALLVQRTEGFSGLDVAHLCQEAAVGPLHAMPATDLSAIMPSQLRPVTYQDFENAFCKIQPSISQKELDMYVEWNKMFGCSQ
The following text describes a protein:
Function:
Glycerophosphodiester transporter that mediates uptake of glycerophosphoinositol (GroPIns) as a source of inositol and phosphate. Does not possess detectable glycerophosphocholine (GroPCho) transport activity. Although no glycerophosphoinositol transport activity occurs in the absence of GIT1, C.albicans is still able to use glycerophosphoinositol as a phosphate source at pH 7.5, albeit slowly. Thus, a second, GIT1-independent, mechanism must exist for utilizing glycerophosphoinositol as a phosphate source at physiological pH. The expanded ability to utilize GroPIns and GroPCho results from the organism's pathogenic nature and its need to occupy a variety of environments within its host organism. This possibility is buttressed by the fact that GroPIns and GroPCho are present and abundant in human fluids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSDLVKSSEVIETTEVPPHNNNNNKRHFKYDSEQRKQRLAGGVKLKDALMILCAGFALISDGYQNNVMSMMNKVFALEYPKEYTASLSTQVSNASLVGTIFGQVIIGLTADYIGRKWSIVTATCFLIFGTMMCAASHGKTVNGMFWMLTIFRGVTGFGIGAEYPSSSVTASEAANESVKRRGGAFILATNLPLSFGGPFALCIFLIVRRICGNHLDAIWRTMFAIGCFWPLSVFYFRLKMVTSELYTKSAIKQRAPYWLALKYYWPRLIGTCVAWFLYDFVTFPNGIFSAGIISNVIPKSEKNNLEKIAEWNLLLGAIALPGVFVGAYVVDILGRKYTMMIGFCGYIVFGLIVGCGYHQIKPITGLFIVFYGLMMSCGNFGPGNNMGLTSSESFATPIRGTAYGISAAIGKVGAVVGTKTFSPIQKNLGDKWTFIIAAICGLAGVLVTFIFIPHLKDEDLLEEDVKFKNYLIDNGWKGKFGIQEYDEEEDLEGSSEDSSDGEIVKNNTKNDVEKVDALK
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTVSYNQSVATSRPWTFLALIFRWRGSVWKAIWIQYSVWLGLYFLVSAIYRFILQDYQRQIFVQLVDYTGARLSYVPLDWMLGFFIAGVLRRFWYLYDIIGFIDNIACSTATYIRGDSDRAKQYRRNIIRYCELTQVLIFRDLSMKARKRFPTLDTVAAAGFMMPHEKANFDQIQYNYNKYFLPFNWAWALVYNARKEGLIEGDYYVTVISEDIKKFRTGLAWVCNYDWVPLPIIYPTIVCLAVHMYFFVCVMARQYVKGSENDPNMIDLVFPFMTSIQFVFYMGWLKVGEGLLNPWGEDDDDFETNMLIDRNLAMGLKIVDEGYDKTPRLEKDAFWDDTWVPLYSEASAHEKRYHQRQGSLAHIKLSRSVSQVRMVPRDGRRASVVKERIVNVKPGNGIGDVFRPSSLLNLMKHAASSHSLERQQSPGSFRMDTLSPTSPTTNAKEYESDKRD
The following text describes a protein:
Function:
Highly active in the 15-alpha-hydroxylation of testosterone. Also active in the 15-alpha-hydroxylation of progesterone and androstenedione. Little or no activity on corticosterone, pregnenolone, dehydroepiandrosterone, estradiol or estriol.
Miscellaneous:
MISCELLANEOUS: There are only 11 differences between the sequence of testosterone 15-alpha-hydroxylase and that of coumarin 7-hydroxylase. By site-directed mutagenesis it has been shown that modification of position 209 is sufficient to convert the specificity of the two forms of the enzyme.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MLTSGLLLVAAVAFLSVLVLMSVWKQRKLSGKLPPGPTPLPFVGNFLQLNTEQMYNSLMKISQRYGPVFTIYLGSRRIVVLCGQETVKEALVDQAEEFSGRGEQATFDWLFKGYGIAFSSGERAKQLRRFSITTLRDFGVGKRGIEERIQEEAGFLIDSFRKTNGAFIDPTFYLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSLQFTATSMGQVYEMFSSVMKHLPGPQQQAFKELQGLEDFITKKVEHNQRTLDPNSPRDFIDSFLIRMLEEKKNPNTEFYMKNLVLTTLNLFFAGTETVSTTLRYGFLLLMKYPDIEAKVHEEIDRVIGRNRQPKYEDRMKMPYTEAVIHEIQRFADLIPMGLARRVTKDTKFRDFLLPKGTEVFPMLGSVLKDPKFFSNPKDFNPKHFLDDKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFLTNIMQNFHFKSTQEPQDIDVSPRLVGFVTIPPTYTMSFLSR
The following text describes a protein:
Function:
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific maternal RNAs (bcd, Tl, and tor), forming a poly(A) tail, during late oogenesis and early embryogenesis. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Required for localization of mRNAs to both poles of the egg, to recruit or maintain known centrosomal proteins with two types of microtubule organizing centers (MTOCs): the central MTOC that forms between the meiosis II tandem spindles and the centrosomes of the mitotic spindle. Required at the final stage of oogenesis for meiosis I metaphase arrest and for progression beyond this stage. Functions with the RNA-binding protein Dcr-2 to promote cytoplasmic polyadenylation and translational activation of certain mRNAs such as Tl and r2d2. As a consequence, is involved in regulating Toll immune signaling and promoting resistance to fungal infection.
Subcellular Localization:
Cytoplasm.
Sequence:
MFSTRISGDMKIFAADVAESSVTATCNTSVQQQQSQQLEFRTRMSAGSPSSKSGQCHLKFGKYNNKTANLLRQVNSCHSSNSSSNTSNNNNEAIKGQQQQPLHYCNSNNSHSWARKKYFGNGNSNNSLLQQQQQPSSFFQRQQQQHQMQMQQEKQATNNNDALMKNQNVVNAHVSDCKSSDSNNNSTSSSNNNSTISSNNNNTSSASNNNTGSSSSCSNRTKPAKWLNENSSSSSSSNNNNISCRNNNTSSIDTKRRNSSAGATAAYYRKSESESGSSEGAAESTETEATRTGGCNSNRTAESSSADGGTQATMGKSQDQEQDQTVKQRPRQQPLSFWKTNYPQTSATQLKDKETVAAVVSAAAVAAAAAAASASEQQQQQQSLSIEHRRNSGYQQHQQHNYYPYYYSQPKQLTIASFLQKEMLPDSTEKSSSNTGGSNMIRSSSNGNSNFSRHQYGHQSTGSGYQQQQQRYRNAQNVYQQYQHQQQHHAQQHTHPHFRRKHSDNGSGINKKMHYSPPGKSGDPADRSASGQQQHHHPHQQQKTIEILASSHFNAMHRRMQGGNNKNGYYQHSYNPMTGEVGSTPTRSEHQNIYNLTYIHVDTEATGEAASAAGSTPVVKPSLLSKPNISITPASSTTPTTVDRALLPAVRSVSAPASGSALPAPANHVRNMFPPPPLAMLGGHGLLSPVTTTTPTKMISCAQLDEAITAAAASGDKLSTSPSYNQAGHYIMPPQQQQQQQLSSHPIPTGTSSHPPPPPPPHMFFHFADGFCNPGQGHQAPPATMWPHSSSPCYPASYGSSCGSGTGAGTSPHNNDGNAGALRPASPALSSSSLGSESQWSGTSNRSRLGHNGHPSISPTPSALGSAQLSPHLAEMRVQHPLHQQHPPSHASHRPHGQMGGHAMSSYVPHRPPPPPHPSISSPNPTPVATGAGGPWYEMILPPDRYLAQARNIEVTVQPEKLICMCKYDNLSAEIWKRFRGAQQTHNKFKLKMRLWRYLYLWMHQPMFERYRICLVGSTITGFGTDSSDIDMCLLPEQGVHPHQHQYHQHHHFHNEKRTEALIILTLFNAVLKDTEVFQDFNLIEARVPILRFKDISNGIEVDLNFNNCVGIKNTYLLQLYAQMDWRTRPLVVIVKLWAQYHDINDAKRMTISSYSLVLMVLHYLQHACVPHVLPCLHSLYPEKFQLGQQDCLDLDLIEPIEPYQALNTQTLGEHLLGFFKYYSTFDFRNFAISIRTGGVLPVSTCRMAKSPKNDVYQWKELNIEEPFDLSNTARSVYDGPTFERVKAVFLISARRLDHTLDLATIFRPIHHVPEHFPQLQQHQQQFEQQLHHPISGQQRSAGGGGDGANPVPSTLNPDAASTFAETTAAHVA
The following text describes a protein:
Function:
Methylates ribosomal protein L11.
Subcellular Localization:
Cytoplasm.
Sequence:
MLKPMYYEFFFIFPKERELFESFLLDATHLALEESSLENLKAFDDKETIGFISQSNWHYFATHDPLKKDLKENLKEKPPHLKNFVILRSQKDLNNSLIPALEAFCLNLKQNLQSEFDFFYLSRNLASKDWLEAYKQAILPVQCTKFYIHPSWHQKPSHVVTNDCIMIDPALAFGSGHHESTSMCLELLSDIDLKRKNALDVGCGSGILSIALKKQGVSALVACDTDSLAVEETLKNFSLNQIPLLVQDKVIYGSTQKIEGRFDVIVANLVADVIKSLYSEFVRLCNHTLILSGILETHLNSVLQIYYNGFEVLEQRQRNEWVALKLLKKQPIN
The following text describes a protein:
Function:
Disease resistance protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. In contrast to other resistance proteins, it works independently of ESD1 and NSD1 proteins and does not require the accumulation of salicylic acid, suggesting the existence of an independent signaling pathway. The specificity to avirulence proteins differs in the different cultivars.
Miscellaneous:
MISCELLANEOUS: In cv. Nd-1, it confers resistance to Mask-9, Aswa1, Edco1, Emco5 and Goco5 loci from Hyaloperonospora parasitica. In cv. Columbia, it confers resistance to Wela3 locus from Hyaloperonospora parasitica. In cv. RLD, it confers resistance to all of these loci.
Domain:
The LRR repeats probably act as specificity determinant of pathogen recognition.
Sequence:
MVDAITEFVVGKIGNYLIEEASMFMAVKEDLEELKTELTCIHGYLKDVEAREREDEVSKEWSKLVLDFAYDVEDVLDTYHLKLEERSQRRGLRRLTNKIGRKMDAYSIVDDIRILKRRILDITRKRETYGIGGLKEPQGGGNTSSLRVRQLRRARSVDQEEVVVGLEDDAKILLEKLLDYEEKNRFIISIFGMGGLGKTALARKLYNSRDVKERFEYRAWTYVSQEYKTGDILMRIIRSLGMTSGEELEKIRKFAEEELEVYLYGLLEGKKYLVVVDDIWEREAWDSLKRALPCNHEGSRVIITTRIKAVAEGVDGRFYAHKLRFLTFEESWELFEQRAFRNIQRKDEDLLKTGKEMVQKCRGLPLCIVVLAGLLSRKTPSEWNDVCNSLWRRLKDDSIHVAPIVFDLSFKELRHESKLCFLYLSIFPEDYEIDLEKLIHLLVAEGFIQGDEEMMMEDVARYYIEELIDRSLLEAVRRERGKVMSCRIHDLLRDVAIKKSKELNFVNVYNDHVAQHSSTTCRREVVHHQFKRYSSEKRKNKRMRSFLYFGEFDHLVGLDFETLKLLRVLDFGSLWLPFKINGDLIHLRYLGIDGNSINDFDIAAIISKLRFLQTLFVSDNYFIEETIDLRKLTSLRHVIGNFFGGLLIGDVANLQTLTSISFDSWNKLKPELLINLRDLGISEMSRSKERRVHVSWASLTKLESLRVLKLATPTEVHLSLESEEAVRSMDVISRSLESVTLVGITFEEDPMPFLQKMPRLEDLILLSCNYSGKMSVSEQGFGRLRKLDLLMRSLDELQIEEEAMPNLIELEISVSKRETKLIIPNRLRAFGQIYC
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Nucleus.
Sequence:
MSDIQQYLLDYDRNKKEATETAQKSATRLKDGQLKLISLVTDLGEYLNSEDGATRSKSEFATQIAFIHADSSVAMSYLAEVLASTPQKVLVSPAATEDSEGLGSCAKALIALEELGKWDDVRVVGIIEALLTNTHPLRQFKQQSERYPVLRLVDTLMAKYREALREHHESRPDFMSRFIAYFDGEKDPRNLMVVFSILKVPMTEWNIGADAQELFDAVFNYFPITFRPPPDDPYGITAQDLKDRLKDCISSTADFAPYAFPALLDKLDSTSMNTKRDVLQTITASVTEYGPRTVSLYSITLWDALKFEILKVEQEDLAEEALAALAAIAKALSQGTSGPLNAYLRPIIKECNEHLEDAPTKQSQAAARILKSIANVSAEVTNILLAGVLPTMFLLFQNADTMAKRRGLLEVLVQLIRANIDVYGDWRVIGPAGDQVESNALAKFREDALKIMLDGLRTAPAKEVSFRLVCLDGLLQLSKARQLLRDEDVSEIIQLLHYIVIHEEPYGKDEVKVAAINGIVEIAHQKPQVVVDKAFPAFLAQLPDTDADGQRDYLTVLEAFAKLAGEEQVFDTVLLRLKNKFSVAVKQDATTEYVVALLSAILYALNKGEAKLAQASEKSSYYNDIALPLLQRASDANTSHKAFEDEKTMDLVGRICNLIIRPQSTEQQNAVAAEVYTLFRGTPQLELAPFNMSLIINKYYTASTLKRCMDPLIADLDLLNPEKLDPPRIRIIFTCLKGIVLRSSPILSTLYTTILNLLSHPQYGTAVAHGFSTLLQPDDLLIKQNHCQILGLHKHKTFALLVPSITQAFREADAQTKPNYLIALAGALRWMPFDIVVEEVAQLTTLLLQSLDLKSADGVKEAAHRHA
The following text describes a protein:
Function:
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon; RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSLKKKTLKQRLRKNEMRQRQKVSKDVRKRVRTGRRQCNRFDDIESGSRPLQELVEEIAAGSAAPTREVALDPRSLTDLLLQTSASLSNTNSGGKTAAKPNVGRGNSESDGKPRLVLPEAPLPEDHPLALPEVQLGEDELGGGKDTNSVPGGKNQYRHHGDPYVFWERVGLHPLLLKALRTMRFTHPTPVQEEVLPSVLSQNVDGRAVGGKEKITPGKGKSGGRGWEKDVIISAETGSGKTLAFAIPILQHVLTNVLVNEVTQGPDGKIGNEETANAAKGKEGKGKKTKGGGKSTERGKSESFKKSRKRLREGEEEGEQLTTAPPTTTFKLQGRLMQALIVSPTRELALQISEAMQQLVQHAPQVIVGCVVGGMAPEKQQRVLNRHPHVLICTPGRLWELMQKNEGCYLGHSLSRRLSYVVLDEADKLLQSGRFEELKNLLERIHCEILPAGYVQEREEGAEAGDAELEAGFWDAEKQKFVPFPKDSPTGDDDKKETPQLRTSRKDEPRLIPMPPDPPEGHRVTTFVTSATLSLQTNYVRRDMRAKKTVIRTSNEDTMGKVLQQLEIKPSNAHVFTISPKVDVAAKIHETYLRCPGDSKDLYLYYFLKMYRERSIVFVNAISMLRRLVKLLEVLGIPVAGLHASLQQRQRLKFIDKFRKGEKRVLVATDIASRGLDVEGVRYVVHFQVPRSTDAYIHRCGRTARCGGTGLSLLMVNAQEHVSFTKLMGSLGRSTGDLEVFALQPTIVHQLHAHLKVALQIDKLQKEIDKSRANNNWARRMSREADVDVDDLIDDDADTENKAKEKAIKILRRRLMLLGEKDMGTSGGKGSFRSSAQAIGAKQAESKLVERAQLQVTQKPKKGSKVVKKAGARKNTEKE
The following text describes a protein:
Function:
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MSEEEKTTIPRVLVSADEFNKANEKLDEIEEKVEFTVGEYSQRIGQQIGRDIGILYGIVIGLIILAVTNILFAGLLKGLLKSLFGL
The following text describes a protein:
Function:
Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Catalyzes the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnB functions as a RNA-binding regulatory protein.
Sequence:
MKDFLEDYKKSVLERKSEGIPPLPLNAKQVEAVVEILMKDPTNAAFAKELLIHRVSPGVDEGAKVKAEFLAQLSQKKLECPHISALEATTLLGTMLGGYNVEPLIVGLESQDKNIAKESAKALKTTLLVYGSFDKIAAMSKTNALAKEVLESWANAEWFLNKEPLNECIEACVFKIDGETNTDDLSPASDAFTRSDIPLHAKAMLKNRIENYEQRIEAIKTKGVPVAYVGDVVGTGSSRKSATNSIMWHFGKDIPFVPNKRSGGIVIGGVIAPIFFATCEDSGALPIVADVKDLKEGDIIKIYPYKGEITLNDKVVSTFKLEPETLLDEVRASGRIPLIIGRGLTNKARKFLGLGESEAFKKPSAPKSDAKGYTLAQKIVGHACGVKGILPGAYCEPKVTTVGSQDTTGAMTRDEVKELASLKFDAPFVLQSFCHTAAYPKPSDVSLHATLPGFITQRGGVALHPGDGVIHTWLNRMGLPDTLGTGGDSHTRFPLGISFPAGSGLVAFAAVTGTMPLNMPESVLVRFKGEMNPGITLRDLVNAIPYYAIKKGLLTVEKKGKINVFNGRILEIEGLPDIKMEQAFELSDASAERSAAACVVRLNKEPMIEYLKSNIKLIDEMIASGYEDKETLKKRRDAMQAWVDKPVLLEPDSNAQYAAVIEIDVAEITEPILACPNDPDDVATLSEVLADTTGKRPHAIDEVFIGSCMTNIGHFRAFGEIVKNAPPSQARLWVVPPSKMDEQELINEGYYAIFGAAGARTEVPGCSLCMGNQARVRDNAVVFSTSTRNFDNRMGRGAKVYLGSAELGAACALLGRIPTKEEYMNLVSEKLESQKDKIYRYMNFNLMENFRL
The following text describes a protein:
Function:
The Set1 complex specifically methylates 'Lys-4' of histone H3.
Subcellular Localization:
Nucleus.
Sequence:
MELTQENTEENEKTHVESIVKFEDSNRGTITDFHIETANNEEEKDANVILNKSVKMEVEEVNGHVDSSSTETDIEMQVIQQPTIPKKPPVSAHRRGPRKHRGNANSQLNLSTADHQRPLYCICQKPDDGSWMLGCDGCEDWFHGTCVNIPESYNDLTVQYFCPKCTEEGKGITTWKRKCRLRECSNPTRPNSNYCSDKHGVDFFREKVKLSTVEPSAIKNLVLFAKKREEFQNLGTVGPTLPSQVPPEVVYNFEIEEANRLNAEIVQLNKEKEVASNKKIFLQLIKDSSRRAVLAYKEREGIKKDLCGFDSRLLFNQQQMNELWEKVSNGAPLSLDMSIDPSPESTCFTEKRRCAKHTSWQVIFTEDFELQESNILQKLNMKQTAKDVMLEHQKQRCLPGIQYDGYARFCHEQLSPEKMANLLK
The following text describes a protein:
Function:
Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. Subunit gamma is the cytochrome b556 component of the formate dehydrogenase-N, and also contains a menaquinone reduction site that receives electrons from the beta subunit (FdnH), through its hemes. Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSKSKMIVRTKFIDRACHWTVVICFFLVALSGISFFFPTLQWLTQTFGTPQMGRILHPFFGIAIFVALMFMFVRFVHHNIPDKKDIPWLLNIVEVLKGNEHKVADVGKYNAGQKMMFWSIMSMIFVLLVTGVIIWRPYFAQYFPMQVVRYSLLIHAAAGIILIHAILIHMYMAFWVKGSIKGMIEGKVSRRWAKKHHPRWYREIEKAEAKKESEEGI
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MTNPNQFIIDALELIIKNRSSYHFQRNLKVAIDSIKLYPMPLKTKDDIKLLRGCGPTIVDIIFQIIQSNKNNNNNNNNNNNNNNNNNITNNNNSDGGIPKELENYIAPESVKEFLISIDQSFVQYLPKLEEAGYNKLNFLKNLNEKAMDKLSIPLGHQTPILENAKILKLYYDYTKLNNNSNNIINNYSLDGNMITLIGKPYIDIDDLKKKCSEDVFLKALSSLFNHKIKTIHVEHNEITAITESHSIPNTTYKIRFEISPDGTIVRDHCECRYLNSTRWCKHKVSVFLIFNENTGERGKRLYCQSTSPTSPTSPTSPTSPTSPTPPKPSRPVTKLSPITSLTSKKSPNNNNNKKEYTPAHRSGAWAILLALYDNEISNGNDNDRGKRYLLKEEILSNGNKYLSSGRMDTGGHWLSNKTLIDHNLISKSGSPLQFILTKTGYELARKLKSFEDSSTDNKNKDDCDNNNIDNDNGSNSSKDEGSDESCDNDNQITITTIDKRNPNWKTQLKNKTNNINNNNNNNNTNIVKNNNNNNNNNNNNNNSNNKNNKRRDSDNNDNFSNGSEERLFLERELFNENWSDSDEELTQFMVDNTVFPNSKVKELLYNEREVIIDNVLLIVDNREVMDKDQSDLLDKLRSSNIQLEIRKLPIGDFIFIAKCRYNNNNNNNNNNDNDNDDNGNNNNNNNNNDIVINREPFELMYDIIIERKKLADLVSSRKDGRYREQKQRIKTLKKFGLTNAIYLIEGDNSNGAIHTDIYEDSIMETLIEDEFIVQLTDGLDLTKEYLLNLYDHFKKSKYRSLSTLRFADYEQIQQVSCSMKLKDLFALQLLQIDGVTPPKAKAIINKYPTPRHLVEAYNNLINEIETSDEETLNQSKNSQDKLLENLTYSQRFNGKKLKIGHDISKLISILYNDENQYQFD
The following text describes a protein:
Function:
Acyltransferase involved in the biosynthesis of the floral volatile isoeugenol, and which promotes the formation of phenylacetaldehyde, phenylethyl alcohol, phenyl-ethyl acetate, phenylethyl benzoate and benzyl acetate. Catalyzes the acetylation of coniferyl alcohol to produce coniferyl acetate. Also active toward 1-octanol, cinnamyl alcohol, geraniol and sinapyl alcohol.
Sequence:
MGNTDFHVTVKKKEVVAAVLPMHHEHWLPMSNLDLLLPPLDFGVFFCYKRSKINNDTKDDDETIKKALAETLVSFYALAGEVVFNSLGEPELLCNNRGVDFFHAYADIELNNLDLYHPDVSVHEKLIPIKKHGVLSVQVTGLKCGGIVVGCTFDHRVADAYSANMFLVAWAAIARKDNNINTVIPSFRRSLLNPRRPPQFDDSFIDSTYVFLSSPPKQPNDVLTSRVYYINSQEINLLQSQATRNGSKRSKLECFSAFLWKTIAEGGIDDSKRCKLGIVVDGRQRLRHDSSTTMKNYFGNVLSVPYTEASVGQLKQTPLGKVADLVHTCLDNVANEHHFPSLIDWVELHRPRQAIVKVYCKDECNDEAAIVVSSGLRFPLSQVNFGWGCPDFGSYIFPWGGQTGYVMPMPSPNKNGDWIVYMHLQKKHLDLVETRAPHIFHPLTACYLDLTATY
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Subcellular Localization:
Nucleus.
Sequence:
MAATVSVSKGVFVFKNGAKAASKKSRTKDKRTQSLYCDSLWYKTYKSLWESIETQIQELNNAMFSNILCSLVNFLKNCYKDTVSEIPAAALLTGINMPDHSVQFKTLKKEIKRSITPHVVTLSGEDCHSLKYLVEIMVNQLVKSEQLIDEDSDSDTRQIKKSQCSFTLLQAWYEELYQPPGTANSPKKQKTKHNKNIIVVIIPDFENFAPKVLQDFIQIASSYLNVLPFVFVFGVATSLNAVHRSLPCYVSSRINIQVFHSTPSTVYLNNILENILFSRQCPFHLGGKVFNLFTDIFLFYDLSVSGFIQNFKYAMLEHFCYGNVMALCQRKHIKQIISDFSHDDLENARRLMSFRKLVESESPEARIALLTDDNYFRNVLLREVRKIVAYLPNLHLFLRCLHVLVGDLPKAPLGKQVRELYACAVSRNITKSQEYKECFQLLAFQSRDELCNKVKRITDLIVNNSEGLEVGRVITDRLNRFLDNLHNLDQEEDENEVAQEGISELMGRLQLREKLLQMSKQNKPMNKYEKIRSGLLNFLSEQFEIYLQEPTDFHFHEIFFFNDISVQTHIIGSHRAAIHTALNDPHVYLQCPCCEIATDSVILPSMPDISIVYKLHLECGKMINLYDWLQSFLSIVDPQETEDNPKVSPQLQARFTQAVAELEYLGFIKSSKRKTDHVARLTWGG
The following text describes a protein:
Function:
May play a role in mRNA degradation. Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.
Subcellular Localization:
Nucleus.
Sequence:
MTSKLEELLECIICDTGAFIKCDRLDKIGKEIYTLTDVIGEIRDKVTREKLNVLPYEIKFREPKAESVLAVSRYAKKTGDFSSLSAVDIRVMALTYQLYTERGGKDIIASKPAKLIAKPSYLNENKLKIESDSFECEKDKIKANVSEKLILQESDSSIDDVNTSGNEASSDTDDEGWITPSNIKQLNGSSDREETSLELPVKVACITTDFAMQNVLIQMGIPIVSVDGYLIRHLRSYALRCHSCLRITNDTSKQYCPSCGNKTLLKVTVNTDDKGNRQYFLVKNKRINTRGMKYPLPLPKGGRFSNNPILSEDQGTNRLQKPLSQRKKLNVFDPDYIARSSPFLINDVHSRAAKLQFQGAGHQKSRRKNPNEVVKKGKRK
The following text describes a protein:
Function:
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
Sequence:
MNHQNLLSITRNLVHPPISSGLVLLSARELDKMRRVGQLAANLLNHLESMVQPGVSTQALNDEATRWMEDHGAISATLGYAPPGYPPFTGAICTSINEVVCHGIPNPKQILKDGDIINIDVTLRLAGYHGDTSRTFLVGSVSATARKLVEATQESMMRGIAEIKPGARIGDIGAAIQAYAEASGFSVVRDMVGHGIGRQMHTELQIPHYGKRGSGLKLRPGMVFTVEPMLNEGTYELTFLADGWTVITKDKKLSAQFEHTVVVTEEGVEILTLA
The following text describes a protein:
Function:
Involved in the early part of the secretory pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
MSALFNFNSFLTVVLLVICTCTYIKIQFPAILNDRTGFRGFFWKAARIGERLSPWVALGCFAMGISTIFF
The following text describes a protein:
Function:
Required for locomotion and mechanical sensing in proprioceptive neurons by transducing dendrite stretching into cellular responses. Required for transduction of mechanical stimuli in a specific subpopulation of proprioceptive neurons that sense joint angles. Probably does not constitute the mechanically activated channel and may rather serve as an accessory module required for the proper localization or function of the transduction channels.
Miscellaneous:
MISCELLANEOUS: Was named stumble because of the walking impairment phenotype.
Subcellular Localization:
Cell projection, dendrite. Membrane; Multi-pass membrane protein. Note=Specifically localizes to the distal part of the sensory dendrite. Does not accumulate in any other part of the cell.
Sequence:
MQQTLSYSSSSPSPSPMPMPSASAAQTPPPNPNLTPNLNIRPSTNPIPRPRSTGGESAFQPAIIPVDYSYRTHTTRSILSAQSMAPSTFASNQSFVRQPSESDAQPYSSLFGDPVPPPLQPDDYFGTAAFETLRNGSVELPSSEEDALVAAMALNALIPAARERIFPSVPYSRTPRGSLLPYLQPPDIQILPNSSGGSSSEQLGSPNYRLLAPDDILNKPDVYDLENEVEEYTVVGQRMSFDDEEDEPTRTPSQAPAKLSVSSITTEDHRGLLSDSYSGRDWFRPAPQHFPEFTRIPRLRPSSKMIMSMKQDEGPLSPLATMIQDMNSSSSGGEERVAPNQSRPVSRDVVLSPKQYLEEQLGLERGSQRQSLEDYRMPPPPADPPPFRRTDLTEQDDSRSVEPEHSLKREMSPVIIRDSIPMGGDYRVEQPRPHKKTAFTILSTGQAASSAPRPPQQAPTRGRHASIQSTSTTTSSPAGRPQISPRRRSIFGSEPRLPELPSALGYTSHLVHQTTDDSPRPSVQFNMSGRHSRSKLAIPQKGILQQRDSLTSSIDTFTPRAQIRRGSIGRDPIRSLPYGQKIKSMETLPLINDQHRSSIPRLHYGSTMDLSRPEPAVFPPGALPRPLKPNLNPTRRQRGLLKIINKEESLTHNPPRSNWCSLDDLSRPSFDGTPNQARRRSSSTSPERRSSTQTVSDRRSSNLSSVTATTSDFSFRRPTLSTLPAAQTLSRMRRKSVQALSPNRIPNRIPSFGQRRQSIYQRDQEPKPLSRHGKIAKPSTLSPIIGTPNKDSSSAQSPNHRSSLMADAVDTPSEVSTRRDSVSRIPVRKSPDSRSSSPPKDFGIPASGRSSRASITRSPSRTMNAGSRSPSRSMHPSRTSSRESGRPGDSRSASRGPPSRPGSRLDQIGSRMDRPNSRLERSSSRAERSSSRADRPSSRFDVSNSRGNSRANSRLSINSSSLRSSSISPATMARNRSMRATTPSRRKSISLSPASAMMGRRKSISPDAVGQNRRVSSRGKPEPPEILSRRNSRSRIPTRSTKVASKSPPSSSKKRSKSPEKPKAMGSTPKSNKVGKGVTAKGSPKAKPKIAASAKPKTKTESLMKPPVKNANKTPVNGRPTTNAKKPASKAISTKDAKVEKGKETGKSVASKSNGKETESSVKSSKSQVTKTKPPGGTTSEAKKPATTKTHGITLEKGTNGTDPVGGIPPLAAQVGNAVLQAVEAVPAVTSEVTVPSTPGGKGAGGANMSKLVRMSSRMSLLSNKSTKVRSDSPQNRKVATVQEHATEKEETVGASSQPMSNDAAAILEKSQKTLENIQKTVTEATDEIHKTISENLTDLKSLENDLAADPSPTPSSGTTMARPGESASRTGTADGSIAPQSSGELPKSPFPPTQPIEASVSVLHPNESSAERIASVPEVECESSDLPTALDASESELVGNVMPTPESGADFKVDAKRRSPDGQGGSTAGSGGLAKSSSQEFLEDKDNVKKGGLCGCCSKLFMPCRRSRCSRCCRRRERNESAEDQPVLWSGNSSATTATNVQVIDETKPKRKKISDWLKSSCCRSCRKKPAIEEHEAHQEEVSKRTNQAANMSTGPRTRGKCGLCLSKVFCCRSVNRVDPTTGDETEMKQCCFCIPCRRGSRPNKKGSTVSWRDQDPELGIKPTESSVVEGASEAAMSAATDAGNDQVKEGCCKRFWLMLLCCRKRKRRESNARRQSIRAPPPSEDTRKKLHVDLVEYSSKMKGAIPVLPLYLAWFCAFCNVVFPGLGTLLSGLFCLCVGIPRFSQFDSARARIGSFIINIIVAVSQFFCVLFCFVGWGWSIWWGTIMLRCAKKLSKIKKVERLELEEEQRQAQLAEAGKNGVAEADKT