lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The master regulator for adhesive curli fimbriae expression; necessary for transcription of the csgBAC/ymdA operon. Plays a positive role in biofilm formation. May have the capability to respond to starvation and/or high cell density by activating csgBA transcription. Low-level constitutive expression confers an adherent curli fimbriae-expressing phenotype, up-regulates 10 genes and down-regulates 14 others.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein. Note=In experiments done with low-level constitutively expressed protein.
Sequence:
MFNEVHSIHGHTLLLITKSSLQATALLQHLKQSLAITGKLHNIQRSLDDISSGSIILLDMMEADKKLIHYWQDTLSRKNNNIKILLLNTPEDYPYRDIENWPHINGVFYSMEDQERVVNGLQGVLRGECYFTQKLASYLITHSGNYRYNSTESALLTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWANDNLRR
The following text describes a protein:
Function:
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MIKVAAAGGGTGGHLYPLLAILETLAKRVDVKVLFFAVKGKIDERVVRKDHPEFETVSIDVRGLLRPLHHPKNLWRTLKIGIATIEVKKHLKRFKPDLVVLTGGYISGVVGLAAKDLGIPIFVHEQNVVPGLAVKVLSQYAKKVFVSFERTRDYLREWQDKIVVTGCPVRETEKEAPLKDFVLVLGGSLGSEAINELMEKVYPELQETQFVHSTGSDDWTERLSVFPNVTALTYIDPMGAYWKKAIASISRAGASTIAEMMYYGVPGILIPWESSAESHQLENALEAERLGYAIVIRENEASPRKIIESIDKVVKKGKIEKMKENPASKISKEILGEIM
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSCPSNGVNPIALLSVSNKTGLIDIAQGLHQAGLRLIGSGGTAKAVRDAGLPISDVSEITGAPEMLGGRVKTLHPVIHGGILSRQTPNDLADLAAQSIHPISVVVCNLYPFSECISKTPPPTIEEAVEEVDIGGVTLLRAAAKNHERVTILCDPNDYSSFLNQCQSNGINGVKESFRKSLAVKAFSMTAAYDATISSYFRIKYNSADSIATAPLEIKNELRQRAQQLSLRYGANPHQAPAQAYVTEGKLPFSVLSGSPGYINLLDALNSFALVRELSEAFQPPIPAAASFKHVSPAGVAVGTSEPLTDVEIQVFGVDGIQDLSPLAKAYARARGADRMSSFGDFLALSHTCDVSTAKIISREVSDGVVAPGYEPEALEILRKKKAGKYCVLQMDPSFQPELIERRQVHGITLEQRRNDVKITPELFKDIVTEAKDLPASAITDLIVATLSLKYTQSNSVAYAFRGGIIGLGAGQQSRIHCTRLAGTKADLWWLRHHPKVLGMKFKPTTKRADKANAIDLYLTDAVWDNDDDEEEGVISTERKEWEAIFEEIPERLSKAERKEWMKKLDGVALGSDAFFPFTDNVRRAAKSGVKYIAAPGGSVMDPAVFKAADEAKMVYCKTGLRLFHH
The following text describes a protein:
Function:
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis (Probable). Required for patterning of neural circuits: functions in the same pathway as RAC-dependent effectors of the unc-6/netrin signaling pathway to set left/ right patterning of the VD/DD GABAergic circuit.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MCSSEECLIDKSWTSEEKCEYIKCNQDSCEGGGYLTWSHYVKCQYNIGVRVILIILGILYLIILFVIMSSIADDFFCPAISGIVSHLRMSESIAGVTFLAFGNGAPDVFSSISSVLTTPKPKADLALGDLFGTSIFVTTVVLAIIIFTKSFKVAIIPTLRDLIFYMTTLAFIVFCFLKFDKIEVWMPATFLGIYGVYVVTVIILGIYRTHRKKRNLKKKNKELEDFLSRPSSAASTTPIFGAMKLKEETISVSALFHFMIGYSQFIKNLTRANLKRTTNNNNNDNKNEKRGIVNLGFSEPYSIPSERKISTIFKQNTFETDLESLESLADLDGSDDEGREEKFGYAHHTVFTSHDQISLVASEIEEIEITTWRSWDWVWDLFNHLKSWPSRDEFSEMNIFIKIVTVIKVVPVFFFKLTVPSNEMSWCKPLFILHCFASIQFALFSIQIITLKPFDGSPGLWLYGLGFSAILAMVAMYFLPLSKEQKYYKEIYSYLGFLMSIAWIYATSNEIVSVVTMIGVVTGLSMELLGLTIMAWSNCIGDIVADIAVVKQGYPKMAMAAAIGGPLFNLLIGFGLPFTIAAAQGKEMELLINPVYRLLMLFLGISLVTTFVALFIQRFTVRRPHAVLLIFIFVVFLIFICLAEFHVLEWN
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 or PEX20 receptors. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 (or PEX20) receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (By similarity).
Subcellular Localization:
Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSSIREEMVTSAVEFLKNPQIADSPLAKKIEFIESKGLNEAEVKEALLRSQGGNGSSSVASQVSSYSPSASQSSVAPSPPPFPDHYRNAPPLPERDWKDYFVMATATAGVSFGLYKVISNYVLPKLLPPSKEAIELDKEAIDREFTRVEALLNTFEEDQKAFYEEQREKSGKIEDTLTEIDAIISKTNEKNLNNEESLKYLKLEIESIKNTLMKNIDSQKSTISSELGSIEAQLDELKKLIVAKPEDEPIRAAPQPSLTTGANSLTSESSGRSSIPHSQSVPIRTQLTTPPSDSDTSGPAKLHIPPATSIPSLKDILRKEKNRTVDTFSKSNLGKDLESVAQSDPDKVEKYEGRRDLKSLERPEEDEKKEDDVEDGGDKDKLASSLESVKLPPSSEQVQAPAPKERTSSSSSRSGIPAWQLAAQS
The following text describes a protein:
Function:
Ovomucin, the glycoprotein responsible for the gel properties of egg white, is composed for 2 subunits, alpha-ovomucin/MUC5B and beta-ovomucin/MUC6.
Subcellular Localization:
Secreted.
Sequence:
MQGCFSKLKGRKGALLLTVNKRVLLLLQLLFDFLSRILSKDSCSTWGGGHFSTFDKYQYDFTGTCNYIFATVCDESSPDFNIQFRRGLDKKIARIIIELGPSVIIVEKDSISVRSVGVIKLPYASNGIQIAPYGRSVRLVAKLMEMELVVMWNNEDYLMVNLWMFSWILCFPEAIPAVLTEKKYMGKTCGMCGNYDGYELNDFVSEGKLLDTYKFAALQKMDDPSEICLSEEISIPAIPHKKYAVICSQLLNLVSPTCSVPKDGFVTRCQLDMQDCSEPGQKNCTCSTLSEYSRQCAMSHQVVFNWRTENFCSVGKCSANQIYEECGSPCIKTCSNPEYSCSSHCTYGCFCPEGTVLDDISKNRTCVHLEQCPCTLNGETYAPGDTMKAACRTCKCTMGQWNCKELPCPGRCSLEGGSFVTTFDSRSYRFHGVCTYILMKSSSLPHNGTLMAIYEKSGYSHSETSLSAIIYLSTKDKIVISQNELLTDDDELKRLPYKSGDITIFKQSSMFIQMHTEFGLELVVQTSPVFQAYVKVSAQFQGRTLGLCGNYNGDTTDDFMTSMDITEGTASLFVDSWRAGNCLPAMERETDPCALSQLNKISAETHCSILTKKGTVFETCHAVVNPTPFYKRCVYQACNYEETFPYICSALGSYARTCSSMGLILENWRNSMDNCTITCTGNQTFSYNTQACERTCLSLSNPTLECHPTDIPIEGCNCPKGMYLNHKNECVRKSHCPCYLEDRKYILPDQSTMTGGITCYCVNGRLSCTESCKAPKKYISCSDSLENKYGATCAPTCQMLATGIECIPTKCESGCVCADGLYENLDGRCVPPEECPCEYGGLSYGKGEQIQTECEICTCRKGKWKCVQKSRCSSTCNLYGEGHITTFDGQRFVFDGNCEYILAMDGCNVNRPLSSFKIVTENVICGKSGVTCSRSISIYLGNLTIILRDETYSISGKNLQVKYNVKKNALHLMFDIIIPGKYNMTLIWNKHMNFFIKISRETQETICGLCGNYNGNMKDDFETRSKYVASNELEFVNSWKENPLCGDVYFVVDPCSKNPYRKAWAEKTCSIINSQVFSACHNKVNRMPYYEACVRDSCGCDIGGDCECMCDAIAVYAMACLDKGICIDWRTPEFCPVYCEYYNSHRKTGSGGAYSYGSSVNCTWHYRPCNCPNQYYKYVNIEGNKLYYFQPQSSNIIIFHDGFFFPISHTTVSSVFIDVTFKTMTTPTISSTSTSKTSISSAASPTSSPGVPLTMTSPALSSTLSTRLLSAAPSTQSTLLPSSTTKLMPTTLRPNPSSLTTSALTESPSPIFSALSTAKTSPLPSSTSFPFSTVPLTILSTLQPCKSAFSPSYCSACSSQFLPLFPTSQHKPCSVHLPSASLMFCFVIIRAGSTHCGMLHTLLPTCMPEGFSMRTAHLFCYFFLALPLSTELCFLYAASTHKMTTVPHIVPSVTTEKTTPTVSATSTSKTSISSEASPTSSPEVPLTTTSSAPSSTLSTSLPSTAPSTLFSTLLPTSTPKSTPTTLRPKLSPLTTSAPTESPTPASSTLSTAKTSLLPSSASSPFSTISSTVRTTSLPGMYSSCSSRWCVCSSQFSPYIPTIQHTPLCCFPPLPIGFSTVTLGTCGELLGLCCDSGWGGTSFLPWSPFSMREHPACVGAGRQCPVPHQVDELLLHALHKTVSKSIPEQNLKGCILILPDPPSLPNRLNVENMVFSAACSCCRPLQLHKEKFQLPCEDPDNPGKRLTKEITVFGGCVCNFDSCIQ
The following text describes a protein:
Function:
mRNA-binding protein which stimulates mRNA decapping by DCP1 and DCP2. Involved in the regulation of expression of multiple genes involved in glycolysis and gluconeogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTDTMYFNSSRLLPSAGRNKTNNLIKQKTRNNRARGNAAKNANNNNYITDIPPPQTLPNGQKPNFGHSSNKKPSFNQKKHSPPSSPSSTTTLGKKNRQNNKETPRQNNKDDTRLLSQNLKNLLLNQKQSPHGSQGIIPMGCNGSAKKLSHSYAGSTFATNGPREAKNLPKPSFL
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MNWVLSSLLFLPPLMGIFHLLTAGALKSPARQWGSYGSALKRIALFWSFISLISTIILWLSLDQEGGFTPLMDIDWIEGPEKIIPITMGGPLVFAVDGISIYFIILTGFIVPCSILISWHSVKYLTKGFLICMLILEFLLYAVFSVLDIFMFYILFEGVLIPMYLILGIWGSREEKMQAAYYFFFYTLIGSVLMLLCLFSLYNIHGTTDYLTLASCSHVPSQQQQKWIFLGIFLAMAVKIPIFPFHIWLPKAHVEAPVAGSVLLAGILLKLGGYGLVRLSWPILPLGAQNLAPAVIAMGIVGIVYGSFATCRQIDVKRLVAYSSVAHMGLVSITLVTHDIIGLTGSIFIMLAHGIVSSLLFILVTILYDRHHTRLIKYYRGLSITMPIWGTIMIVTSLANVAVPPSGNFIGEYLSILSSFNWNPIIGVFVCSGVILSAVYSFYFANRVTFGASGSLITSPRDVNRREFYITASMIFFAFLIGVYPIFILEVIQNSLFFIAL
The following text describes a protein:
Function:
Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions; Also has diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Sequence:
MTKQDLMDIIVKVAPGSPLREGVDYILDAGIGALIIIGYDDEVEKVRDGGFLIDCDYTPERIFELSKMDGAIILNDDCSKILYANVHVQPDNSYSTTESGTRHRTAERAAKHLKREVVAISERKKNVTLYKGNLKYRLKNFDELNIEVGQVLKTLESYRHVLNRSLDSLTILELDDLVTVLDVANTLQRFEMVRRISEEITRYLLELGSRGRLVNMQVSELIWDLDEEEESFLKDYIDDETDTDSVRRYLHSLSDSELLEVENVVVALGYSKSSSVFDNKIAAKGYRVLEKISKLTKKDVEKIVNTYKDISEIQEVTDEDFSAIKISKFKIKALRAGINRLKFTIEMQR
The following text describes a protein:
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission.
Subcellular Localization:
Nucleus.
Sequence:
MSAEASGPAAAEAPSLEVAKPSELEPGSAAYGLKPLTTNSKYVKLNVGGSLHYTTLRTLTGQDTRLKAMFSGRAEVLTDAGGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARHYLVQGLIEDCQLALQQKRENVSPLCLIPTVTSPREEQQLLASTSKPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYETPRGPDPALLEATGGAAGGGGASRGEDEDNREHRVRRIHVRRHITHDERPHGQQIVFKD
The following text describes a protein:
Function:
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasmic vesicle. Membrane; Peripheral membrane protein.
Domain:
The N-terminal C2 domain associates with lipid membranes upon calcium binding.
Sequence:
MASSNSTGPYQEESPLSLLFVKVIRARNIPWADWMSNADCYVSLWLPSSTNKLLKTATAADTSNPVWNETFQFKISANIKNVLEVTLYDEDTVSKNDLLYKMLFDVSKITPGETMKHSFLLNPPGKETLDVEFSMKKMPAHPETIKTNGVLVAREVCCLDVSVDKQKIPENLQGEELLLQVENSCEKLYKMGLNPTAGPNHTETCSFHSIKRYDSQLSAHLQGANPEDVESQVNVPLNSLTEGKEETVRLHAKPASINEKVPSCWTGLSRRVGRSLFGHKDSHLEMKVKAQNCKEKFDVRMGFDLCDDEKDFLRKRKKVAAAALKSALKLDRDLEEDEVPIIAVTTTGGGARAMTALYGTLSGLKKLNLLDCVFYITGASGSTWGISNLYEDAEWSQKDLDVPIENARRNVCKDKKSSFSLEKILKYREEMKKRAEMGYKTSFTDIWGLVIESMFHNGDGKTTLSNQRKAVERGQNPLPLCLAMNVKHIENTTLDFKEWCEFSPYEVGLLKYGAYIRSEDFASSFYMGRLIKKLPESRICFLQGLWSNIFSINLMDAWFAAVSSDNFWHRFTRDNIQDLDGEEALRRKSASPSLGTLLIQPAGYIGSTIRDILTSRPIDGEHHNFLKGLQIHKDFHSHKSFCCFKDTELDKFPNKLTPYSDDLCLVDSAYYINASFPPLLREERKVDVILSFDYGLAERFKSVEQTHEYCCNQKIAFPKVNLTDNDREKPKECHVFTKSEDLEAPILLHFPLVNDTFRTHKAPGVKRSPEEMEGGAVEIEGRSPYSLLKLTYSKENFDKLLNLTEYNVMNNEEAILQALRDAIAQKQKSRGNSGTNTNP
The following text describes a protein:
Function:
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
Sequence:
MRFPRAVLFDLDGTLLDSAPDMLATVNAMLSERGLPCITLAQLRPVVSKGSRAMLAVAFAHLDAAAREALVPEFLKRYEALLGTQAQLFDGVEVMLQRLEQAGCVWGIVTNKPEYLAQLILPQLGWQQRCAVLIGGDTLAERKPHPLPLLVAADRIGVAATQCVYVGDDERDILAARAAGMPSVAALWGYRLGDDDPLSWQADVLVEQPPQLWEPAAWPQP
The following text describes a protein:
Function:
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
Subcellular Localization:
Mitochondrion.
Sequence:
MIKQLLISPSCKILPTNRFIYNWYSCYSTNKPRKSIESNQKKSTTTTTFTPTPTSTSTSSSQSQSPTTDQILFEQFQKSVIKNDIKHNPNNQPFWMKRNRTIKSKHSHWNPTKKLSRSEMNKLRELKQYFPHFTTADLGKIFHISPESVRRILKSKYIPDDD
The following text describes a protein:
Function:
May play a role in pattern formation during embryonic and imaginal development. Is not essential for visceral muscle morphogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MLLHESAASMEQSMPENLSTHMYGECEVNPTLAKCPDPVNVDHELPTKESCASTTIVSTSPTSATSTTKVKLSFSVDRLLGSEPEESHRQSSSSPSTKSCCDGSILACCSFPHCFSQANAESRRFGHATLPPTFTPTSSHTYPFVGLDKLFPGPYMDYKSVLRPTPIRAAEHAAPTYPTLATNALLRFHQHQKQQHQQHHHHQHHPKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDIAPTSPAAAAAATSQNGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQQQKYITKPDRRKLAARLNLTDAQVKVWFQNRRMKWRHTRENLKSGQEKQPSAVPESGGVFKTSTPSGDGTPQEALDYSSDSCSSVDLSEQADEDDNIEINVVE
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).
Sequence:
MARLIYLMGPSGAGKDCLLSALRNATPQNRVVAHRYITRPADAGAENHVALSKQEFIQRAEQGLFALHWQAHQHCYAIGIEINLWLQHGLDVLVNGSRAYLPEAQRRYRHQLLPLCLTVSPAILAQRLRQRGRENSEQIDARLQRAQHYQQQLPSHCLQLCNDGELQHTLNQLQQLLTLDTPLSDPVEDKPCN
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MAQDWSLKGAGAANLVYAYCGEDERLSGHVLRVRKGTAHAASEVDIALWEGVLVHKPGDAAGRELSYVADVMAPLLGRQYVFPGIPCRLPVDMREAMRPGGSSDHFPALLQPDHTLLQAADERRERGRVPCGVCRLISAAGTRAPRYPEVRILDLSGGRWPGERKMFVGLQQFA
The following text describes a protein:
Function:
Binds to several small RNAs that accumulate during recovery from UV irradiation. Contributes to the resistance of D.radiodurans to ultraviolet irradiation.
Subcellular Localization:
Cytoplasm.
Domain:
The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity; The MIDAS-like motif in the VWFA-like domain binds divalent metal cations.
Sequence:
MKNLLRAINPLNRPQTERLDERQVRNNAGGFVYTVSDESRLTRFLVLGVDGGTFYASAQKHTVQATDFVRELVQRDAALALRVTLDVVRGQRAPKADPALLVLALIAKTAPNAADRKAAWDALPEVARTGTMLLHFLAFADALGGWGRLTRRGVANVYETADVDKLALWAVKYKARDGWSQADALRKAHPKTDDAARNAVLKFMVDGVLPKVDSPALRVIEGHLKATEAQTDAAAAALMQEYRLPLEAVPTHVRGAEVYRAAMQTNGLTWLLRNLGNLGRVGVLTPNDSATVQAVIERLTDPAALKRGRIHPLDALKARLVYAQGQGVRGKGTWLPVPRVVDALEEAFTLAFGNVQPANTRHLLALDVSGSMTCGDVAGVPGLTPNMAAAAMSLIALRTEPDALTMGFAEQFRPLGITPRDTLESAMQKAQSMSFGGTDCAQPILWAAQERLDVDTFVVYTDNETWAGQVHPTVALDQYAQKMGRAPKLIVVGLTATEFSIADPQRRDMLDVVGFDAAAPNVMTAFARGEV
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MDAAASPASSTNRAAEAGSAGSSADSAASTELVVKRLIKRGIPARYAERGPEGLIEYVKEDQSRVPDVVGALFPDHEEIKDPNQPGDETQATACRTAYLDMCQDAVSWVQWLMFGRDPKDALSDTAVVCSGARGICGAVWGSNDIAYRCKTCEHDPTCAICVPCFKAGDHSNHDYSMIRTTGGCCDCGDVTAWKQNGFCVKHKGPGHVPSLPQDFVVSAAPVLEAVLIIWVSKLEKAHHASEGKPKKWMSMPKAEKVASQTSLAIIKMLLELCRAGESMLSFTAKYTGMKSIGVLDALLKTESFMSKHVIESLHELLYKLLGDSSFKHAFALTFISHYPRFMRDLVAEELANPSSPNAMISRTRDHAVLSNFSVQIFTVPTLTPKLVLEYKLLDMLMASIKDFLVACVGEDGRLLVSKSPISGRLYSRVTEDIRYVMTHFEVAQYVTQHRKDLCKVWLEILAFVQGMHPQRRVTSIHVEEENEDGDAAYQLEVQMATIHPLFVLGAASPSVSFPAEGSSLSGVTSVEDCADDDDDNMFVRHAKVGRISPKERNDMDMGSSSGADVEMADVANASCAGADESQCTESIFGVRSRDGRGAQQSVTAVPAHQLIWLISECVSIIDKWLAVDNSRELAKGPGKSVAESGPASVQHRGSLWRGRARGLTRGTARAAAVAEPAAPAATPPAVVEGEGGPGRGLREWLRRSRRPYAAIAILDEDRGNSRASGVSASGTDSADMDVDTAGVSETVRSRDTSGTEWWMCTDDSSSLSRVGQSNADGWPKVDFDVSRQDVSFHIPLHRMLALLLHKALEMHSVGMEPGSSSENPKSTNPSPLENLSTLSQLLPSKYQVPGFAASLMEHPLRLQVLCAQVQAGMWRRNGHPTNSICDVYRTVPWCEDSLELDLLMLQCCAVLAPPEKFAERILSRFGLSEYFNLFLWRPNEYEASLAQEFLVLLIRICTERGFCGLTQRESLRRELIQRLAVADATHSSLLKALPRRLQDSPYLHECLTAVANYRRPSGMQQGKYVLKEECWSELDLYHPRWSPRELQCAEERYLRACKASPVFLQLPRWKKPYSPLQNLGRFVVSGTVHEILLSVFFHAAFSINPGDSRATEGLLFTGLHLLALALDVCSSANYNCEHDKNANDAASSPEGIESRLPYSGNMNSSTFKVSSPKHASVEEENELPPLLARSIHREFVGGAVGSDAGMTEPQSLLSLLVMLLRKYSSGEGVMGTVVETSQYSAGDLIKSLLLKFADLHRGCMYEIESLVPEILHRPSAALNIASNSNSAGDKESEDKQAVTDVEKRKALARERQKAIMAKMKAAQDRFVASLKDENIDREKAEAVSKQTRESVEVGEGSSEDSNSTPCALCRDTGSSSQLCFLTLVQKSRLLALAQKPTPSWERASATVGVSSSDRGIDGGRNASESGNVEMYTTAHLWNWIQEALGDAATRERLLEGEALLEVFRNGLHPRNPVRLNAVGTPPARAVEPADTEVDEPEINGDNSEIETCPETLPLHPTNWWEEESVPQFSDEWTSSRELNLVTVLAEYVAAVSRDRRRQGEREVPRTVEVEVAREGGPIRQRRITPTRSNSDAFVITGLGMHDTSGVYLSACGHAVHQECLDRYVSSLLQRYYSRALFEGVQIVDPDMGEFLCPVCRRLANSILPAFSGNAIPDNQSRALNTREALQLRPCAVESKVCKVETSSSTNLQLDQAFRLLLNAESLVNKTGFRKAVSTQLSDSIKGALETLAIRLYGLFHPDKDHLSVQAHGRVPQSLHLWDVFRYSLMSSELAARTRQRTMQGSLSGLVMLEEGGDGAKGSILPLLLQAAKATQGQSRQIVLLRSRGLQLLVDSIIHGVTRDPFPEQTLAGNYTSLQQYLEKSQDSSDVQFWKRLADPVLIHDSFSSLIWLLFCLPAPLPPEGGPFTVLVHLFYMVCLTQVIAYHGIALASEAEVGSSVPSFVTAVQAALSGAALSPVDDDKSAVPPCPSLDVIRQLTLPYLRQCSLLKKLLSGTGQVVPVARAHLWELSQNSSSAFSRSTSTPSGDGRHEEEEVANELEELDQLETLFAIPPLTSLLTDERLLSVALTWCQHARTAIGKEFHIKSYIPRPVRAVPFKLMELPHLFQDLLQRYVKERCLRCGKVPDKPALCLLCGTLVCAITSRPCACSSLNKQGECYRHAMACGAGVGVFLMLRRTNILLQRCERQANWPSPYLDAFGEEDMDQRGKPLFLSEDRYAALTAMIASHGLDYSSLVLAQTTRQTLF
The following text describes a protein:
Function:
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MYWRRAALVGTRLIPVRSSSAGRLEGPAGISGSGMGNSTSSSLGNAATAPVNQIQETISNNCVVIFSKTSCSYCTMAKNLFHDMNVNYKVVELDMLEYGSQFQDALHKMTGERTVPRIFVNGTFIGGATDTHRLHKEGKLLPLVHQCHLKNSKREEL
The following text describes a protein:
Function:
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
Sequence:
MTETKEEKVHKVFEKISPSYDRMNSVISFKLHVKWRKETMKLMRVQKGTNVLDVCCGTADWSIMMAEEIGPEGHVTGLDFSENMLKVGREKVKEADLHNVELIHGNAMELPFPDNSFDYVTIGFGLRNVPDYMQVLREMYRVLKPGGQLACIDTSQPNIPGWKQVFNAYFRYVMPVFGKFFAKSYKEYSWLQESTREFPGMARLAEMFQEAGFSYVRYISHSGGASATHFGFKKKEQ
The following text describes a protein:
Function:
Required for normal export of the pre-40S particles from the nucleus to the cytoplasm. Its subcellular location and association with pre-40S subunit shifts from mixed cytoplasm/nucleus to all nuclear in RPS19 disruptions, suggesting it acts after the ribosomal protein.
Miscellaneous:
MISCELLANEOUS: Present with 21600 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MARASSTKARKQRHDPLLKDLDAAQGTLKKINKKKLAQNDAANHDAANEEDGYIDSKASRKILQLAKEQQDEIEGEELAESERNKQFEARFTTMSYDDEDEDEDEDEEAFGEDISDFEPEGDYKEEEEIVEIDEEDAAMFEQYFKKSDDFNSLSGSYNLADKIMASIREKESQVEDMQDDEPLANEQNTSRGNISSGLKSGEGVALPEKVIKAYTTVGSILKTWTHGKLPKLFKVIPSLRNWQDVIYVTNPEEWSPHVVYEATKLFVSNLTAKESQKFINLILLERFRDNIETSEDHSLNYHIYRAVKKSLYKPSAFFKGFLFPLVETGCNVREATIAGSVLAKVSVPALHSSAALSYLLRLPFSPPTTVFIKILLDKKYALPYQTVDDCVYYFMRFRILDDGSNGEDATRVLPVIWHKAFLTFAQRYKNDITQDQRDFLLETVRQRGHKDIGPEIRRELLAGASREFVDPQEANDDLMIDVN
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MRAALRLLATATATVRPSARFLKPGSPTGLTGLGTHPSPRSALLYLYNHTLDKLKQIPEHSLYRQSAEALTKHRLAIVEQYVPDGYDAWQERARKLLEKHKSDLTARQFDGQHARLVEGPDGRAYFIRQMVPPQDWRDVEWDGAVLDPHFSWVQTGEDVVGAVKLEDSDKLLELDKIRESDPVAYRQGLRDLGIKMGGVVEDKSPVEWESEPPLSAEQIAEMEARIGSGLIEEVVQVAEGELKLVDIMTQARPWEALEEEAPEGQWTYFERKE
The following text describes a protein:
Function:
Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for the translocation of the substrate across the membrane. Also mediates KinC-dependent biofilm morphology.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGNDDKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRSFQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKAAYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTILEARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAVIVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQSIAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSWLTPALVTIILTVVKAIVVLLAVVICGALLSWVERRLLGLWQDRYGPNRVGPFGAFQLGADMVKMFFKEDWTPPFADKMIFTLAPVIAMGALLVAFAIVPITPTWGVADLNIGILFFFAMAGLTVYAVLFAGWSSNNKFALLGSLRASAQTISYEVFLALSLMGIVAQVGSFNMRDIVQYQIDNVWFIIPQFFGFCTFIIAGVAVTHRHPFDQPEAEQELADGYHIEYAGMKWGMFFVGEYIGIVLVSALLATLFFGGWHGPFLDTLPWLSFFYFAAKTGFFIMLFILIRASLPRPRYDQVMAFSWKVCLPLTLINLLVTGALVLAAAQ
The following text describes a protein:
Function:
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTTTSRSGRQLWLPWLILVVSLTLITYSVDSFIRLPQQLGVSQQCRMSRMWPAYIDHTSNLEPFSPSGLWRKYRLYLYRERHFEPMDLPTGSPALFVPGNSGSYGQVRSVASSASRQFYKENGSGARRDEWKDAPPGVAHTDWYTIDFNEDFSAFSGTTLIEQATFINEVVSYLSDRYASAATHSYAAGERNTTVPILAHSMGGIAARLTAHLPNYPVGNIDTIVTLSTPHAFPPVPFDSSVEYVYSLINTPLDASRVTSRSARNVPPLLVSIAGGLLDTQLPSDPSSLSLARIGEAIAPSRISTYTGSLPSLWSSVDHVAVMWCDQLREKIARGFLLDMMAFGRVSDERNAGGVSGRSSVLRRRRELWRRALSLFDVSDAGNGEIGPLELTPSPDWLLEEDRETFVVENESPSFQRPTSGPDSALSVDQQNTVFRIPARMGDSDDGLHAFELITNLCVGWNPSSGMGAPLPQPVELVVQLCTSNPDSSDPVSGQRTSCRLVMPWQWELIPPSFLPRTDILMQESSQHIDTHLPENRPFPSADEIYHVPGYAFQRLRLDADLLQRQRIDWIRVERKTDSGVFVHQRGLKSFVRGGWMRQAAGRLKKHGSSLLLTQDQDSDIQHHYQDAGFATTSAIPIASEWLLKGFSSSLLARRIELVPSQCLVENLALYTLQSNDESLHSTDASFSPFMRVSDRATGDSRWYPQLASPELVRRIRARTYKGEPITFPLSLHGNAPFMPPARDSLNEIRVQLWTDQALLRPVPGKSLPCRSSVDSIRLSVDWKASAGLVLLRYRFLLAAWPLGLLSVCIGLSWLTWTQKPELPFPSPLTSITQPVFRTPFIGNRVDPLLGLLACTAIALILLDGMRLWLYRCMSSAEARGPTSSLIGMVLGLHNHASSAGLIPCFLLVSYATLLVIVAIIQWSFSLIAAIVTRFGLAHKLDWVGAATASSDPLKWNRRSMAGLAILLLSVVLLVPHQFVFLIMFLLQLLNTLRALLELQSNRGPPQSQESRFHQHLSILMMLVLLLPQKASFLVTWVRNLASVGIKTPNTMAAWMDHNLLDVAPIVVLVWLMAGGRMLEPARSKMEAKAIVFGFSIVGWYALVWGIRYTYRTYDAFNALCLVLAVCHWRSRRAGSRSHYSQGHAACNVAKHSDETSGMLHAHGKDEGVNLGDAPAEEFELRSGLASARLPIHHLALPSSVDPQSGGASIAEGNASTCAVVESSAQTNLGGDKLDELIADYLDVLDRYQRARNATSALFSSGYLKLTRAKIELGASRLSSNSYDSRLLAEVRATISNESSSQSSCGGLPAQASEISHISVARVQPDYSHLENDDYVLIQDMDESKVEKADSTIAGLRRRAAVGVTLSETDVVEGSGPHKHSPRGSLNDSVLRPVRVSAADAEGRGDAIKMSAVQPEKGHSKNSKYDVISTNQGDDQLGRMEQTKKVAAKPDALLQFGGLPSTALRGAQVDLRKALNQLLGAESHVHDDGVLQLALRLEVLTSAISTLKATAANQSECEKR