lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MARGLSRFLVPLLLVAICNAASVSHPISDSHRSAALDVFVPLDGSYKSLEEAYEALKSLEILGIDKKSDLSSVTCENVVKVLGSPSSALKDVFYALSVNGILKCKSGEDVSKDIVSKLQAGAKDAKLLLDFYYSIRGLVLVKEQFAGTDPSLGDAAAIFRSIKALSQSDGRWRYSSNNAESSTFAAGLAFETLAGVISLAPSEIDQSLIQTVKTGILKLFDSIQKYDDGTFYFDGSEGPISTTASVIRGLTSFAASESTGLNLPGDKIVGLAKFFLGVGIPGDAKDFFNQIDALACLEDNRQGYFHAIYAIYLLRLVVHHLRIMNKMTAEMISVEKTIICATVVVYDFRFSVPLILSLPSTVISLSKKEPLKVKVSTVLGSKAPALSVKLAQALNSKGSSVINNQELKFDADSATYFLDSFPKNFDVGKYTFVFEILLDESANEKAYITEAQTKVPIAATGAISIENAEIAVLDSDVGSVESQKKLDLTKDGGVSLSANHLQKLRLSFQLTTPLGLVFKPHQAFLKLKHESQVEHIFLVKTSGKKSEVVLVKFLKLRLDWLLLKNYLIYLLATDFLGLVEKLYYLSGKYEIQLTIGDASMENSLLSNIGHIELDLPERPEKAPLPPLQPTDPYSRFVPKAEISHIFRVPEKLPAKQLSLIFLGLIVLPFIFFLIGLTRLGVNIKSFPSSVGAATSALLFHGGIGAVLLLYVLFWLKASSQKLLDLFTTLKALSLLGVFLLFVGHRTLSNLAAASNKLKSA
The following text describes a protein:
Function:
Histone acetyltransferase, which by binding to the host chromatin, may manipulate the expression of host genes involved in anti-inflammatory responses to evade clearance and to survive in the intracellular milieu. Acetylates histone H3 at the 'Lys-9' and 'Lys-14' positions.
Miscellaneous:
MISCELLANEOUS: On the 2D-gel the determined pI of this protein is: 9.47.
Subcellular Localization:
Secreted. Host cytoplasm. Host nucleus. Note=Colocalizes with the chromatin in the nucleus of infected human macrophages.
Sequence:
MSFGFPTFSQNRFTEQYSGLCPIAPGRGAGLQPCRRDCPVARWLVADHPVFGSDCRCRMMVGVNRVRIGRHELTGA
The following text describes a protein:
Function:
Directs RNA polymerase II nuclear import.
Subcellular Localization:
Cytoplasm. Nucleus. Note=shuttles between the nucleus and cytoplasm.
Sequence:
MPLPVLRVKRKASEDPVNALYLELGNNPNSVSSTKRRKFAGRYYFKLSQTLKQDDRYIQINDESSEPTHEDVRNIHSHTKISSLKKNNYGIPVVQTSEDVVKAPTHMDLGSRENTKGILSFSSPRYTIQNLPSTQSNRVFDAIRVEQGHTTYHPHPQLDSMIQEYLSNGDLPLQQSTEDYVYDIYEASSKEPNKPTFAYGVIDALSIPDAFRSSLEQELVSETVDSDKDDPLHDEIDEDSNAESFYQNSYPDEDEWQDSSENDEFAYSDDAEQDFYD
The following text describes a protein:
Function:
Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.
Subcellular Localization:
Secreted.
Sequence:
MKSSVLLSLCTAALVAGAAHPLEPQVVLKDGQSTFTEPDEYLIELSPGETRWVTEEGKWELRRQNINFFDITHHEDLGTINANRLIEKSVKFPSKPAFNKTVVPLLKKLKKDNMRKHLETFTSFHTRYYKSQYGAQSSAWLLEQVSKTLSDAGAVNASVKAFPHPWGQSSIIATLPGKSNKTVVIGAHQDSINLFLPSILAAPGADDDGSGTVTILEALRVLLKSEGILDGSAPNTVEFHWYSAEEGGLLGSQAIFQSYEKEGRDVKAMLQQDMTGYVQKTLDAGEPESVGVITDFVDPGLTEFIKQIITVYCDIPFILTKCGYACSDHASASKAGYPSAFVIESDFKYSDSKIHTTEDKIEYLSFDHMLQHAKLTLALAYELAFAEFK
The following text describes a protein:
Function:
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
GAQRGAWHRVGAEEIPGTVLAAVTGPGSQPTDTSCLTWEGQRFRGKATIMEKMMSLPFPKVRRSLTSQDHQPAPDNRIASTVVGRLKIDEDPAMGFRQIFLLKNANEKWICTDDNLQAAPPKCLRDGHRF
The following text describes a protein:
Function:
Required during the early stages of meiosis for meiotic recombination.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to meiotic chromosomal axis sites and DNA double-strand break (DSB) hotspots.
Sequence:
MSYSVSAAQLWSRKLAMQAEDMQQHQKSQSNQIASCLAEMNTKQEVVNQTIGQLGRSISEVQQQNSQLVLQSLNQINMSMQQVALGIQDYASRINKLEQTMSDMNLKFEALQKEQNSNTKTLADCTSQMTIITKKLDAELKKRYMTTKQTRTVQNQTMPRSNTTTKKRVLAIDFLADDDY
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
Subcellular Localization:
Cytoplasm.
Sequence:
MKERDIFEEIVNLGKKRGKLTYDEINEALPSEYYSPEEIEDLIDVLSDMGVRVVDEDEEEVFLEEEEEIEEEEHVEDLVQAYFNSMGDIPILTKEEEVELAKKLQEGKSIIKETVMGLSLYQKILEEINKEEDSETLTEEDKAEEALSRTIIRLENLINDIEKIEQKIKEYGSLKELRKQINEKKRVGENTKQLENLYKEIHAEIKKIENESGLKIDELKNIWQKIYKAKCLVEDTKNELITRNLRLVVNIAKNYVGRGLPLLDLIEEGNIGLMKAVDKFKYEKGFKFSTYATWWIRQAITRALIDQTKTIRVPVHMMEFYNRVTKASRELTQQLGREPNNEEIAEKLGVPVRKVEEVFRAIQDPIGLQTPIGDEDTELEDFIGDKTSPSPVSEAERTELSEHIQRILKTLTPKEEKVIKMRFGIGEDRDHTLEEVGRYLSITRERVRQIETKALRKLKHPSRMRLLKMLTSDIVENKK
The following text describes a protein:
Function:
Required for optimal fertilization at the stage of sperm-oocyte fusion, plays a role in optimizing acrosome function, the translocation of IZUMO1 during the acrosome reaction and the fertilization process. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also a component of the CD9-positive microvesicules found in the cauda region.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome. Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Note=Located in the connecting piece of elongated spermatids and sperm (By similarity). Also located in the apical region of the sperm head after sperm capacitation (By similarity). Located on sperm equatorial segment and neck. Associated with epididymosomes from the caput and cauda epididymis.
Sequence:
MILRKKLSYLWTLGLCLVASKSPPKAPSITNDRFIEECLRLHNEARTNVSPPAADMKYMSWDEALAKTAEAWAKKCKFIHNSCSSKSFKCHPTFQYAGENLWLGPLTISAAKFAINMWYDERKFYDFNTRSCSQVCGHYTQVVWAYSYKVGCAVAVCPNLGSPDSALLVCNYAPAGNYPNMSPYTNGTPCSMCQGDTCENNLCRNKERDKSQRYPNWNPSGTRQLIACNPLYLISVLLTIF
The following text describes a protein:
Function:
Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.
Sequence:
MHRILVLDDIAQEGIDLLEASEGIEYEVRTKLKGEELRQSLNEFDAAILRSGVTITPESLEGNTRLRALVRAGVGTDNIDKPAATRRGIVVMNTPAGNTVSTAEHTFAMLLAMSRNIAAANQSLVEGRWDRKKFMGTQVAGKTLGIVGMGRIGREVASRAQAFDMDVVAFDPFLTDDQAESLKVRRVATVDDMLPQIDYLTVHTPLTPETRGLIGMEQLEKVKPGLRIINVARGGIYDSEAMVEGLKSGKLGGVALDVYENEPCTDSPLFGMPGVVCTPHLGASTEEAQTQVAVEGIHLLLNYLRTGEIRHSVNVASLDPKTLAELRGHLNVAHRLGLFLSQLHGGGIDHARLTFRGEVSGKDTRVLNNAFCAGLLERVVEDANVINSEMLLRERGIELTCERVGDKGAFTSSITAEVSGNGKTVQAGAAILGHEMPRLILVNGYRLESFLDGKLLVFVHKDVPGIIGRVGTTFGSHGVNIAQMAVGREGDAPGGAAIGVLSLDGEVPTAALDDLLAIDAITECQVIDMPGAGQLPSWLS
The following text describes a protein:
Function:
Binds the poly(A) tail of mRNA. Involved in the export of mRNA from the nucleus to the cytoplasm.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNNSKLSVPGQYEDESSTIYVGNIDSRLSDEEIIKHFSKYGQVESIFRRLLDSFYPKEKAKPFKPPKNGVQYGFVKFVNAESIEEVLKDAKGMTLGQRKLTIKARVVNPAKLTDKKFKPNDTSITANVFNPSIQNNTDEENVKPGLKQSQIKEFIPNVEERNWETVRGINSRNPKPETTLTIPSLGLEDISMQVVPNAFASTLPLSILNLPAEVTPIDLYNHFKQAGVVKGTAVSQFLDQRGFRYGEVIMDSVESCQNAIEKLNNVPYKGSILEVSIKNKASSSVKSIPTTPTGESLWPFPSENANKTQINIENATCSKMTWIMGSPTKEKSQWGSVSTTGVSNQQNHPAAWNPDNKPQSIVHWDSLRESSPSIPNSPIDPSNLYVKNLDDTVITCKSQLEDLFSPFGSILSSMLACYPNSGISKGYGFVAFRQIEAAVRAKDTLNGMMVGKKRIFVCFAERKSDRIRRLQAFFANKPTSEQTAQQDNKALFVKPERSSTVTIRKPIESSTNKISENPTTLSSKVENKNEPKTGENKEPSQTNEYVNCKQENKELSGQLSGNLDIKKEAGKLSHDGEQGNLLKPLVFHANTKLNNRGSAKMGSTATNLKKIQDMLHNKKLSNAYFVPRARATTCTTLTYVTVEPSHFQDEDCNESTNMLSLVGYMDSYPEATSNIQKMNSYHIKDSNKENFLSTTKVNNNSPTTIQLTQI
The following text describes a protein:
Function:
Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
Sequence:
MRVFYAVTFYEEAKEKLIEYKNIVVNNSVKGRFTNKNNFHLTLEFIGEVDEKKLSLLTNILYKLQNPPKEVVTSYIGSFKRRDKEIIWLGIEENKCLITLQRELRNLLINNGFQIEDRKYKPHITIGREIVRKGFIEKNIFPPLHIPIASIALMESKRVNNQLVYEPLEEQILVV
The following text describes a protein:
Function:
RamA is a master regulator of acetate metabolism. It positively controls the expression of acnA, aceA, aceB, ack, pta and ramB genes in the presence of acetate. RamA is also a positive regulator of rpf2 gene expression during growth on glucose as the sole carbon source.
Sequence:
MDTQRIKDDEDAIRSALTSLKTATGIPVTMFATVLQDNRLQITQWVGLRTPALQNLVIEPGVGVGGRVVATRRPVGVSDYTRANVISHEKDSAIQDEGLHSIVAVPVIVHREIRGVLYVGVHSAVRLGDTVIEEVTMTARTLEQNLAINSALRRNGVPDGRGSLKANRVMNGAEWEQVRSTHSKLRMLANRVTDEDLRRDLEELCDQMVTPVRIKQTTKLSARELDVLACVALGHTNVEAAEEMGIGAETVKSYLRSVMRKLGAHTRYEAVNAARRIGALP
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MVELLRPSLGEAFVIQNQQVALDYIGKRGATVGVTKENRIKYLMKILQKEMLPHVGVGEYCETKKDYYGYIIHRLLLCALGRRAEDDRDHYGNKRRELAGPLVGGLFRTLFRKLTRDVRCVDNGKDVNMQFAIKSLAVSGVRYAPVSMSYTDTTPVLCSIFWTLQVSTSPYLCRVQCPCRCRCFILKYSLATGNWGQPNAAGTQAGVSQVLNRLTYASTLSHLRRLNSPIGSEEKLAKPRQLHNSQWGMICPAETPEGQACGLMKNLALMEISPAVIPQATKVFVNGCWMGIHRDPDKLVTTLRELRRRLSIISLMIPIPPPLDIVITHIINQSLKADVAMIMEGRVQFKPQNICTRSLWSLQSSFFIVDKQRLLKKKKDINALKQEYPEEGGWYALMSKGLIEYIDTEEETTMISMTISDLVQARINPEEAFSDTYTHCEIHPSLILGVCASNIPFPDHNQSAMRKQAMEIYATNYQLRMNAIVAIACYSGYNQEDSVIMNQSSIDRGSYRDEEKKMGTLVKESFGRPDRANTMLDDDGLVPPGTRVSGDDVIIGKTTPISQGQVLRYTRRDHSISLRHSETGIVDRIGDKFSSRHGQKGIVGMTYTEEDMPWTVEGITPDIIINPNAIPSRMTIAHTGIEGDGTPFTDVTTIDNISKALHKCGYQMSGFETMYNGHTGRRLHAMIFLGPTYYQRMKHMVDDKIHSRGRGPVQILTRQPTEGRSRNGGLRFGEMERDCMVAHGTAHLLKERPVDQSDVCRVHVYIPYDCKLPSKMVMAILMGNIVQKSSQSTVNKKQHIAPRMFSKEVKSTTDKKKGA
The following text describes a protein:
Function:
DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination. Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed. Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps. Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. LIG4 regulates nuclear localization of XRCC4.
Subcellular Localization:
Nucleus.
Sequence:
MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHGDAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISITLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDLQTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILCGTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLEQLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFEDVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDVVKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSGIKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAIKALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDKCELQEENQYLI
The following text describes a protein:
Function:
In AWC olfactory sensory neurons, required for the detection of preferred food sources.
Sequence:
MKATFVLACLLVIAAVSHADLLPKRMDANAFRMSFGKRSVSNPAEAKRMDPNAFRMSFGKRSAEQNEQANKEDKATSDKLYDDTKFEEMKRMDANAFRMSFGKRSDAHQAADDQVEYVNDDFSLPEQKRMDANAFRMSFGKRVNLDPNSFRMSFGKRSTVGYNLDARNYFVGLGRR
The following text describes a protein:
Function:
Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAGAVPQFMVDEYVLAYHGPLLYEARVILAEVWDESNTLLGTVGPHYFIHYKGWKQTWDEWVPESRLLKLNEAGFAKRRALLDAQAKKGRSTGGSGGTGSPGAGKGGLKDKKKDTKKRGRDAMESESDFMKRPEVKIVIPDVLKLVLVDDWENVTKNNQLVALPRKPNVRELLEEYRQYASASKKQERSDRATALLSEIISGITLYFDKALGNNLLYRFERAQYVEQKRQNPEKPMSEIYGAEHLLRLFVNFGPFIAYTNIDTESLNILRDYINDIMQWMIKEQKRLFMKEYEETTTHYQNLSRS
The following text describes a protein:
Function:
Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate. Also displays malyl-CoA thioesterase activity. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate. Also has very weak citramalate synthase activity in vitro.
Subcellular Localization:
Mitochondrion.
Sequence:
ADIPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKNEARLRIVKTLEDFDLGPTEKCVRVNSVSSGLAEEDLETLLQSRVLPSSLMLPKVESPEEIQWFADKFSFHLKGRKLEQPMNLIPFVETAMGLLNFKAVCEETLKVGPQVGLFLDAVVFGGEDFRASIGATSSKETLDILYARQKIVVIAKAFGLQAIDLVYIDFRDGAGLLRQSREGAAMGFTDVITVVITPSSSPSPSNCKSDYVSFVFSVFQGAFTFQGSMIDMPLLKQAQNTVTLATSIKEK
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MMTETQTPFSLAAAFLQCGSPGQTFNMETLLKPEFGNYSPNSIGDHGSDGEESTICTVCCDEASGRHYGVVACFGCKGFFRRTVRAGKNYICRYNKKCRIDKAGRNVCRSCRFQKCLEVGMEPDAIRPDRDKTGRQKNPRRNADGSIKKNSNASILGDLPCLTKFSLKDDSDSSSNSPSSRSNSAPLEPRPTFLDESVLTTLSEIENIVIQLQDNVESDIQNLPHMGEAIVKPSIIATRALMNFNGAKGDADAECVSANLRRLIVFTFDYINTLRPVADLHPLEKLAIARSVVAPFCIMFCGHQSVAGGGPEVDSIYLPTGHKLPPSQLLFTKDSDQKKHILLENKADYVRRNMSETIISQFRRLQVTKTEMVALKAIMVLDPNVKGLSEASYDLLAVARESVQSALYSHLIANHGNAEATSRFAQLLLMIASATRVAYSLSSFFQLSRDVNFDIDYVLDELLFLDRM
The following text describes a protein:
Function:
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MNPIRRRKIEAEAVRTVAMMILSGKVKDPRVHMVSVHRAEISEDGKNMKVFVTAICTDKKKIKVLSGLNSASGLFQATLSGKLGLRITPRMHFLWDEEYIQSLDESLRLTRKPTNTD
The following text describes a protein:
Function:
Thiazole kinase involved in thiamine salvage pathway.
Sequence:
MDVGAKEEEMGQVWWGHRAWSLLSAVRARAPLVQCITNLVSMDIAANVLLAAGASPAMVHSLREVPDFTPRCDAVYVNVGTLSEDWLPSMRAAASAGRPWVLDPVAAAASGFRMKACLELLSLCPAVVRGNASEILALASRSTAASSNFKGVDSSHCSVDAIEAAKALALSSSAVVAVSGAVDFVTDGKQVISVSNGVPMMQKITATGCAVTALIAAFVAMEPSDAIVAAACALAIFGLVGEIGMESAKGPASLRMHLIDALYCLNEETVTSRVRISLRP
The following text describes a protein:
Function:
Component of the target of rapamycin complex 2 (TORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization and anabolic output (By similarity). In response to growth factors, TORC2 phosphorylates and activates AGC protein kinase family members, such as Akt1 (By similarity). Within the TORC2 complex, sinh-1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by mTor (By similarity).
Sequence:
MGHVDREDLLNVIRHELRLEDDDGPGLCSRLLLNPDRKCRAGGLPLDFRLKNGDLMDDGDAGFDDIYEIPLYEEPIHTRTLINDSLALRTAEKIKEEGRRDNFYTGPLDELFVKQEVNWPPKTPISTEKSAIERYLEENSANLNNPLGEYSKFAATTTDPSRQIEIIIPMSCDEEIGFKTLKIEVLTTARIREVIGYCLLQYYLTFDSYLPGEVDDYQFYLAEEDGEIEHELPPLDSSKLVGQVGFTCLGLVSRIKKNGNSRQKRAVAVWFVDKDQYVIEVDNMEKPLRWLRDEAFRLREETVKEREPLFQGLLDIKEYYMEAVDNFDVKLDLEASISSARSLEFVMIRKNSSRAGFHPRGGRYGRQMSAMLTLKMPNSPIAAGPMTPLPTVMEESPAVAGTSNGFGFPKAESCGAIASTPGVTWNDDGGQLSSFIVQRIHKFKPKWKANLIFRWTCFEIEKYREDRSAFLPQGYQKHTKVPWEYVGGVRTQLKDAKAGRVDMWQITFFWLPVLSDETVKDVIGDAEWNLNLVAKIYANEEKWRSVTLETFFKQDVDEIFSQTNSILQARDASIYKAFSHSSFGTLSPAASADLALMESAEAIVSPSSDAPSRSSNGKNGGKFRKMSSLMASVMGRRKSDSK
The following text describes a protein:
Function:
Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes. Recruited to the promoter of ICS1 and other defense-related genes (e.g. PR1, PR2 and EDS5) in response to both biotic (e.g. Pseudomonas syringae pv. maculicola ES4326, P.syringae pv. tomato DC3000, and microbe-associated molecular patterns (MAMPs) such as flg22) and abiotic stresses (e.g. UV-B, drought and abscisic acid), thus triggering rapid defense responses by stimulating salicylic acid (SA) biosynthesis. Involved in basal and systemic acquired resistance to P.syringae and Hyaloperonospora arabidopsidis. Mediates resistance to drought and sensitivity to abscisic acid (ABA), especially for ABA-mediated signaling process that regulates early seedling growth.
Subcellular Localization:
Nucleus.
Sequence:
MKIRNSPSFHGGSGYSVFRARNLTFKKVVKKVMRDQSNNQFMIQMENMIRRIVREEIQRSLQPFLSSSCVSMERSRSETPSSRSRLKLCFINSPPSSIFTGSKIEAEDGSPLVIELVDATTNTLVSTGPFSSSRVELVPLNADFTEESWTVEGFNRNILTQREGKRPLLTGDLTVMLKNGVGVITGDIAFSDNSSWTRSRKFRLGAKLTGDGAVEARSEAFGCRDQRGESYKKHHPPCPSDEVWRLEKIAKDGVSATRLAERKILTVKDFRRLYTVNRNELHNIIGAGVSKKTWNTIVSHAMDCVLDETECYIYNANTPGVTLLFNSVYELIRVSFNGNDIQNLDQPILDQLKAEAYQNLNRITAVNDRTFVGHPQRSLQCPQDPGFVVTCSGSQHIDFQGSLDPSSSSMALCHKASSSTVHPDVLMSFDNSSTARFHIDKKFLPTFGNSFKVSELDQVHGKSQTVVTKGCIENNEEDENAFSYHHHDDMTSSWSPGTHQAVETMFLTVSETEEAGMFDVHFANVNLGSPRARWCKVKAAFKVRAAFKEVRRHTTARNPREGL
The following text describes a protein:
Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MSEATDKQKQVSAETPLERDLKSKQQSIAATKRKQYRDDKSQIRKQARFEVSTTPEPEQSDSSATTATITELPKKRYYRQRAHSNPFSDHRLEYPKSPESMDWSNLYPKQYDISKVEIADIGCGYGGLMIKLGPQFPKSLILGLEIRVQVTQYVEDRIIALRKNQEIINDKKKKESGGGTGDGDDNDYSYQNIAVLRGNAMKFLPNFFVKGQLSKMFFCFPDPHFKQRKHKARIITNTLLSEYAYVLREGGVVYTITDVEDLHNWMVKHLDEHPLFERLSKEWEDQDKCVEIMYNATEEGQKVTRNKGSKWVACYKRLPSPDDCE
The following text describes a protein:
Function:
Negatively regulates glucose metabolism by binding directly to the promoter region of the kgu and gad operons. It also negatively regulates its own synthesis.
Domain:
Contains an N-terminal helix-turn-helix DNA-binding domain and a C-terminal domain that binds the effector.
Sequence:
MTDAPAHTRERVTISEVARVAGVSKATVSRYIGGDRQLLAEATAKRLEEVIERLGYRPNQMARGLKRGQTRLIGMLVADILNPYSVAVMHGVETACRQHGYSLVVCNTNRDDEQERHHLVALQSYNVEGLIVNTLGHHPGELLNLQRDIPMVLVDRQLPELNVDLVGLDNADAVEQALDHLQAQGYRDILAVSEPLDGTSSRLERVQAFGASISRRPGMRQQVLEIGAGLQGQLASFLAHSGHGPQAIFTFNGVATLAVTRALLEAGRNLVADVGLIALDDLDWYPLVGKGITALAQPTERIGVAAFESLLGRLRGDSGAARRIDFKANLIIRGSTQPQ
The following text describes a protein:
Function:
Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MASRLPTAWSCEPVTFEDVTLGFTPEEWGLLDLKQKSLYREVMLENYRNLVSVEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEVAGPRNAQIQALYAEDGSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALDQLRELCHQWLQPKARSKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQPAEGTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDVMLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRDCALSSALEDTLQGGVQEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQKIDNPESQANSGTLDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQHQRVHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRTHTGERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS
The following text describes a protein:
Function:
Catalyzes the transfer of a palmitoyl moiety from palmitoyl-CoA to the 6-position of the mannose ring linked to the 2-position of myo-inositol in phosphatidyl-myo-inositol monomannoside (PIM1) or dimannoside (PIM2).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Permanently associated with the membrane.
Domain:
The acceptor mannose ring localizes in a cavity at the end of a surface-exposed long groove where the active site is located, whereas the palmitate moiety accommodates into a hydrophobic pocket deeply buried in the alpha/beta core of the protein.
Sequence:
MTLSGRIPLGGQVTDLGYAAGWRLVRAMPEAMAQGVFGAGARYAARNGGPEQLRRNLARVVGKPPADVPDDLIRASLASYARYWREAFRLPAMDHGRLGEQLDVIDIDHLWSALDAGRGAVLALPHSGNWDMAGVWLVQNYGPFTTVAERLKPESLYRRFVEYRESLGFEVLPLTGGERPPFEVLAERLTDNRPICLMAERDLTRSGVQVDFFGEATRMPAGPAKLAIETGAALFPVHCWFEGDGWGMRVYPELDTSSGDVTAITQALADRFAANIATYPADWHMLQPQWIADLSDERRARLGT
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MATPTNNYNTIVGSPMPTATTAATTTTVTPTQKELNIEDLQLFPSILDIISRIKDDEIDLIRAINLANETRTKTIETLNKLPGINRSLENQEELLKTYKQTLKKKVELLEKLKKLEIFEKYNKIKSTSSQSPQIQSKLELQTELSQTEPSQTEPSQTEPSQTEPSQTESSQIESSQIESSQTETEKSKETTEDIMKE
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MPAPLFKRWAPPTPAIKPASSPAKAVTPKASSPVQERRESPAPAPQSATPKPAKKPKKRKRDAEVQDEPAEDSSKKHKAIFNKFEKVAKLAEAKSQRQEEEDSEEKDEQPAEELHDLQPMPQPAPVPDTAFEPTFSTLPPWLAQPTTVESSRTVPFAELGVDAHYLKKLESQGFKDALAVQTALLPMLHQGFEQHLGDICVSAKTGSGKTLAYLLPIIEALKDRAVPTLSAIVVVPSRQLVNQALQVAEDLCAGTKIKVGTALGNTAFPPDAEAAGQVEGSVPPHAAGAKDLHERASQQFRTGFVEKGGILDDLMNMPQDHIPQYDSGVDILICTPGRLVEHIEHTTGFLLNSVRWLVIDEADQLLNQNFQGWASVLMDALHGETPVDFMNAQERLLKRERDANSMWSAILPARRQLTKIVLSATMEKDLTKLGTLRLKRPKLVVVQDEATEVQPLDHEDNNFELPSTLDEFSVHVADGSNKPLHLLYVLLNYVFTGIETGENNEDEDSETGVAEHPSRVLVFTKSTENASRLSHLLATLAPAFKNHLKTMTRALTAEASRKLLKSFGTGEIKILIASDAASRGLDIPDITHVINYDMPTSITSYVHRVGRTARAGKSGGKHGRCSPKTEAAWFIKQITKGDSGKAGE
The following text describes a protein:
Function:
Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSLSINTSQTQAWLESLRPRTLPLAFASIVTGSALAVWLDSFKPAVALLALLTAGLLQILSNLANDYGDAVKGSDTEERIGPLRGMQKGIISHQQMKVALIITVILTIISGIALIAVACEKPSDILGFLLLGLMAIVAAITYTVGRKPYGYMGLGDISVLVFFGWLSVAGTYYLQAGHFDSIVMLPATACGLLATAVLNINNLRDIENDKANGKNTLAVRLGPVVARYYHALLIGAAIFCLALFSILHLHSWHGWIFLLAIPLLGKHALFVLRDPTAAGMRPMLEQMVKAALLTNILFAVGLVFS