lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions in nuclear protein import as nuclear transport receptor (Probable). Involved in encystation process. Constitutive expression enhances cyst production and increases transcription of endogenous genes involved in encystation. Level of mRNA of the transcriptional factor myb1-like protein increases in early stages of the encystation process followed by increased mRNAs of the cyst wall proteins cwp1-3.
Subcellular Localization:
Nucleus intermembrane space. Cytoplasm. Nucleus. Note=Localizes to the nucleus intermembrane space in trophozoites, but relocalizes to cytoplasm and inside nuclei during encystation. Colocalizes with arginine deiminase (ADI) inside the nuclei at late encystation stage.
Domain:
Lacks the importin beta N-terminal (IBN) domain.
Sequence:
MDLASFQNLLQQCQTEQDTQKRKEVEDFYFKYKQEEPASYVANIIEVICSNSSSSNYAAILFRRDMEQSGDVAAVYRAGNGNPECVHEVMVRILNTMLGQTSSNSIRFLSEILGVHLERILESDPQGGVAQFPEFFQALETHFAAPTTTSQLRVGFLNCIKYICGLAYTSVTKIGGKAIIDLIFAGLEDQADTVAVAAIKCVNALILYGDSDDEDEKNDSVIPNSVLQQFVYKIIQRLPAMIGRHNFMDAEQALEQLVDIADMNGAVLKPMVKDVHILVTGILSPPEIDDSLKRLTIVLFSYLCENISDIRKRAKKAISEIISQFIFPYCGLFDDTLTQAWLTSEDPHHFDDQNSLLGYAESALDRISTTLGYKVIFPLIKDFVSYAKANPTVHNCFAVANIFTITAEGLARLVTKEDIVFTIDTLLELSNHPHQRVRYSVLSAIGQLSEDYAPTFQTFHEKVMPLLTKMAQDPCIAVAAHSLGALVNFLEHLKKAETYLYKDALEPVITMHLMQSNHLLSNTNSLALVASLSNTLLKNDFADMCKNYIPHILGMFTNVMETLRKSPNMSLNKPRLSYISRILECLSIVAGTLPQLFAPHIDPLLTAIMELFNFSIDDAESSLLKYTLIAVSRIVDIYPETFPKYMDPIIAKLNDIFNLKYIEFDNVNEFAVTDDDDCSFTISPHVLQLQAVGFDVISGIMRKTPAAFAPHLDAFLTKIQDRSFHTGSISESLKLNSIECICTAFRVAVAAPTVASPPAVHQRAFTMLIAATESNIDDIDIYQSIADSMAEYVMDYCKYITSTKDMTSYTETVNKVFSLLENFEDQCRKLLEVSIQDLECDDDLDPEETATMVSDTVDDFSDAIATFADVYGTFAEALGDLSLDFMSPLLMPVIKRWVNYYTSTKKNGISGAQVAFLTSAVSILADIVKYLSPANSKSLVEPFVTIIIENTKLNKEWVEINQVCCYTAGLLFEKYEGDPGLAILIPTLLANATELIGVVKSGELVSKEALAAYDNAVTLSARMAQAFPTELGNMSGGLTQFWASWLDLASTVQTDREEVIASIQLIISAFARNDPNFMSGNLVHALYAFLSLYFGDHHISIVEDQTNANLIEGANTVLTQIAGHGTILADTIAKCSEYVQKTYSLYTSVRQ
The following text describes a protein:
Function:
Involved in staphyloferrin A secretion.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTKYFFSSSFLLFLGNWIGQIGLNWFVLTTYHNAVYLGIVNFCRLVPILLLSVWAGAIADKYDKGRLLRITISSSFLVTAILCVLTYSFTAIPISVIIIYATLRGILSAVETPLRQAILPDLSDKISTTQAVSFHSFIINICRSIGPAIAGVILAVYHAPTTFLAQAICYFIAVLLCLPLHFKVTKIPEDASRYMPLKVIIDYFKLHMEGRQIFITSLLIMATGFSYTTLLPVLTNKVFPGKSEIFGIAMTMCAIGGIIATLVLPKVLKYIGMVNMYYLSSFLFGIALLGVVFHNIVIMFICITLIGLFSQWARTTNRVYFQNNVKDYERGKVLSIIMMDRGMIPLGSLLMSICADVFGIVRTFSIMGISTICITMVFYFINRKLKLKLEESNHGIS
The following text describes a protein:
Function:
Transcription factors that activates genes required for endodermal differentiation but represses genes involved in proliferative divisions, thus regulating the transition from proliferation to differentiation in root endodermis. Required for Casparian strip formation by positively regulating the expression of the Casparian strip genes CASP1, PER64 and ESB1 and other endodermis-specific genes, thus triggering correct localized lignin biosynthesis in root endodermis and subsequently regulating global ion homeostasis.
Subcellular Localization:
Nucleus.
Sequence:
MGRAPCCDKANVKKGPWSPEEDVKLKDYIDKYGTGGNWIALPQKIGLKRCGKSCRLRWLNYLRPNIKHGGFSEEEDRIILSLYISIGSRWSIIAAQLPGRTDNDIKNYWNTKLKKKLLGRQKQMNRQDSITDSTENNLSNNNNNKSPQNLSNSALERLQLHMQLQNLQSPFSSFYNNPILWPKLHPLLQSTTTNQNPKLASQESFHPLGVNVDHQHNNTKLAQINNGASSLYSENVEQSQNPAHEFQPNFGFSQDLRLDNHNMDFMNRGVSKELFQVGNEFELTNGSSWWSEEVELERKTTSSSSWGSASVLDQTTEGMVMLQDYAQMSYHSV
The following text describes a protein:
Function:
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
Domain:
Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
Sequence:
MPLQLDITYSFQRLLEKSRNIDGRLVSRQLTHIVDSFILSKFESSKIGLKSGDELCIIAMGGYGRMEMAPHSDIDLLYLHNGIKEERLETIISKINTYLYDSGKEVGHSCRTIKECFLYLDNMSTYHAFLDARFLAGSKSLFEKFKTNFLEKLPVKLTKRYNEIKEEILTSRFLNEERPILLSEPNLKTDLCGLRDIQYMFWMEKPFRNLPSLSGLSILPAFQRGEIQLLQEAYDFILRVRIAMHTITSRKTDRLDLNLQQEVAEYLGYGKKEELSSVEKFMHVLYRHQKNIYFIIRTYLDSILEKRGSSKGENFSYEDLNFFKIGDTVFPPTTGTLFTNPHTIYRDVMLSFRMIQEKNLQVSGTLLNEFRFASNFLDDDFKYSSEVNEEFLKILRTPSQRGRILKLMHESGVLGAILPEFGACTNFPLFSYHHEYTVDEHTLLILHELDLLDRGEFQDEEIQKTYNECSKIELLALAILLHDAGKVKEGDHSEYGAELVVSLGDRLGLDEEDTDLCRFLVEKHTLMSELSSKRDIGDPKLILDFAKIVGSRERLRKLYILTVIDTKSVGTGVLTNWKSAILNTLYQNTIPYLAGDSKDNFEETGPTREIQLENLKNYLIDKEDLNEEISKSIVEFANQVVPSSYLNTVSNRKILRNFKSIGILAQNPTFKTIFETEQDPAFVTIDVVTSNQPEILLDLSCAISSEGLSLLGMKSYALGEYWITTVQLTDSTGGGNIPQNKLDRVENKLKSISSGNLKRESIAFQRTDWNPRKPAPESIVNRSIQFYNEDLPDVTIMEVRMPDVVGLVYRILQIILYLDLKVCYLRVSTSADYAYDSFYLQTSNGCKLEDQNLLLKLKEKILTIQLGEQILEEVSI
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Subcellular Localization:
Nucleus.
Sequence:
MPDNAILFDHLATQIQQTVTPMFARLNSRDCITVEKLVKSFMGQMKENMNDQVSGTEVEITNTTSYSMFELPDWYDSVIEALHRKKQKSISEIYVKFLNMVFLFYYVTLSSLAEIEKPAIIIIFEDFESFSPAVVLDFVKISSYYTCKLPLAFVFGIATTVSAVHKSLTYSGTSLVEIKLFKSYPTKVYLENVLSKVLLTPNHRFKLGFRPLSLLVDNFFCHDFSVSGFMSGLKYAMMDHYYSNELSILSMPSQPNQAIVITLKQQIKALSHEQLELVRMLPSFRKYVDGLPPKEQKKLILEDKLLKDKIMELLIGLEQYHQLFFPMLQCLDNVTRILPKNPLGKLTIEVYLRCIQSNITEEQDFKDSMKLLGSTCSEELISFLTSCIQAIEEYAVNSKNNFALFEYDKYEFLLDGSAGDEEFADNDDDNETDQNQKIDRFKLQERLRQLSKRKKRPTRFENCRSEIVEKLTELFKKYAKCPSEVPLYEVCYYESVSVLKQHVTASPRMSIQKALTDFSSYLKNETKDYEQTPDICVAYQTLEDKKKLVNLEDWMQEFIHEAKFVDSKTLCNGNTKLNRKDKRTNKQQYQEQNQEYEQELQMRFMRAVSELQFLGFIKYSKRKSNYISRLTWIG
The following text describes a protein:
Function:
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
Sequence:
MSNKVGNSKNNKNKSIKFAPKHKDKSYDNEDFNAVSKKSSISVSDLPTKGEEKHRIMALSFPIKLSMWDFGQCDSKKCTGRKLERLGYVKSINLTHKFKGIVLTPSAKQSISPADRDIVQNLGVSVVDCSWAKVDSIPFGKMKGGHDRLLPFLIAANPVNYGKPFKLTCVEAVAACLFITGFTAEGHQVLGGFKWGSSFYKVNKDLFEKYILCANSQEVVQIQNEFIAKCEQDQKDRAANIEYDEFGLQLNPNRILRTNNDDDEENGDEDYCDDDDEDEDEEDEEEDHECDSECDHDEEEEEDNDEENDEEEEDGEDDDDDEESEEEEEVDEEEEKRQYRLKKELQKKKAEEKKLQKQMGKLNLK
The following text describes a protein:
Function:
Required for vacuolar ATPase assembly.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLYRLSEKQQTDLRCNKLTVDGFELVKMLKELRLHNRNINFLEFLRGVQIVPSDSVFLGEIDENSHTQDNTTTSILKEKELYDGIPLLPSMAGVSMDPEREKKSELRLMKNQISAIINILFTVVGTVTAVWYCTSSLSIEKKIALCAFSAILVLVADTFLYVRYLSAQPVRTSKNHTRQIIYTWTTNDPVLQSNEQLAIELGAIPSLKEKKNQ
The following text describes a protein:
Function:
Not known, interfere with mitotic chromosome segregation when overexpressed.
Sequence:
MEETAHELTVKQYVEQQRELEREAREVLPYSFDTCTYSMGYLKQPLYACLTCQKASGSLNAVCYSCSISCHADHDLVDLFNKRHFRCDCGTTRTHSIPCNLRKSVDECGSENDYNHNFEGRFCICDTVYNPETEEGTMFQCILCEDWFHEKCLQKTNKGIAIPDAETFEWLVCSECSEKYRDHLLNQKHESIAGTERAPLFLSENFRENLCPCESCISLRNLEMPMLVAEEPIYEPPEDSEDGISEMNEDPSESGEMIEQVISSTMNDVLRILDRLPRVQANESVYAYNRLKSELTDFLTPFARENRVVTKEDISNFFLERSRISKNLR
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MAMKRVLLLLAATALASVQGEVINQSAKRTFDLTKHVVREHTEFSFSDADAEVTQYDVAFPRALETQLAYVSARCGKTPCEIVPATHEHAAKAKTPEDAALYTVLLKKPLAKGETGSVKITAFLTRVLTPYPAEITQKEDQLVLFEASHLITSPYVTKTQTTKLKLPSGNVESVHAAEPISRKGSVVSLGPYTDVEAFAAGVEESPLSVHYKNHAPFMTITKLTREIEVSMWGRVSFEEVYDMEHTGAKLKDGFSRYDYVQLHQRSASFHEMYAHLPKDSVNVYYRDQIGNISTSRLRPAGRTGSHLDLEFKPRFPLFGGWKSQWYLGYSVPTHSVLTHVGDKFKLEVDFSTPVQGASVDDLTVKVILPEGATNVQVNVPFSLDGTSETTRQTYLDTPAIGRPVVVLDKKNVVAAHNVPFEVTFDFPQQFMLHEPLLLVSAFLAFFIVCMFLFRLDISIAKKPVQKKKTE
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MLPPQQKKKKSFTSFVNACSYNLSSHLYNSVVKSQFKPFTFNLKYVLQGVTYTEQPTSNNNIAKHLSTLFRITYRNGFTYHLPHCSLTTDAGWGCTLRSIQMLFLNSLIRLQEPNPGFGDDAAEKVQQNFIIHSMEERREYVQLIEDTPKQEAVLSLYKMFNLKIVRQNNQKGTNYLSPSTCAIALSQLVEMWDQRPCHVIYSNTFPKEIQPNTLLMISAPLNEKTISCLDNTFVGGVVCGVDTKAIYVCGRTGNMLLLLDPHFVQKAHEDGDFDIVDYSVKPSDLRMVRLTELVFGNCIWGILVREDNIEILKNWCKTSLGVTNEEEIREMVSVGNEEGFEVLDF
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
SKAQQLLQGLQATDESQQLQAVIEMCQLLVMGNEETLGGFPVKSVVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAEQALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFVADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNIQQLLVVTPPILSSGMFIMVVRMFSLMCSNCPTLAVQLMKQNIAETLHFLLCGASNGSCQEQIDLVPRSPQELYELTSLICELMPCLPKEGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDSRIIEAAHQVGEDEISLSTLGRVYTIDFNSMQQINEDTGTARAIQRKPNPLANTNPSGHSELKKDDARAQLMKEDPELAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIVVGALQMAEILMQKLPDIFSVYFRREGVMHQVKNLAESEALLTSPPKACTNGSGALGTTATISPGSASVASNVPADLGSPSLQHSRDDSLDLSPQGRLSDVLKRKRLPKRGPRRPKYSPPRDDDKVDNQAKSPTTTQSPKSSFLASLNPKTWGRLSTQSNSNNIEPARTAGVSGLARAASKDTISSNREKIKGWIKEQAHQFVERYFSSENMDGSNPALNVLQRLCTATEQLNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSRDIRLKRFLHVFFASPPPGEEPIGRLEPMGNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGTGSSFSLNRGSQALKFFNTHQLKCQLQRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVRGYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQFYIGDHLLPYNMTVYQAVRQFSIQAEEERESTDDESNPLGRAGIWTKTHTIWYKPVREDEDGSKDCGGGKRGRAQTAPTKTSPRNAKKHDELWHDGVCPSVLNPLEVYLISSPPENITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPTGEFNNSKLTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLTNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFNIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQCALETLSMNGCSVEDLGLDFTLPGFPNIELKKGGKDTAVTIHNLEEYLRLVIFWALNEGVARQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKTDTWDAKTLMECCRPDHGYTHDSRAVKYLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGQQSFHLS
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MLRTGQMILARALLKHVYPDNVIINHQERIRINSKYNQVLKWFSDYQSKEHLYGIHQIVHMKKAMEKKIRQKALENYARRKQQLQQQQQQRYGKNSVRVRIDNYSDSSSDSEDEWDNVEEWLAPTKISNVLRQLVKNQNLDDLEMYVPNDGVIYREYINQLCNPYYFNNYKNNDQNNQNNLSMNQSPPSRVPSEVFNHPLSVNDDDQDYYHFNPNKWKSLIIMIPLKLGVDRINTSYIRKLKSILSIPQSLGFIGGKPKQSFYFIGFQDDQVIYLDPHFVQDTVDPSSNNYSETFCGCIPQKMSFSNIDPSLSVGFYCKDKSSFDDLCDRLSKLENDEFPIISISNKLPDYQLEVDLVEDFYENLAGATSVTTANQNFNNNIANLNPNMNTSVKFGSFDTDDEFQLVNNNKFNNNNNNNSINNKQLPKSHQQSTKQQKDKEQFSAIYSHPPNFSSDDEIDDFTFV
The following text describes a protein:
Function:
Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes.
Sequence:
MAEAAAAPISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEAPKEWGKLDEWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCSWRRAGPKVPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDVSTDAASGVHANFSTTIPPTSWQADLPPHHPSSACSDGTLKLSTAASTEADVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPVQEGAWESQGSSFPSQDPVLGLREPARPERDLGDPTPTVPQDETSPGDWLFGGVRWGWNFRCKPPAGLNPRTGPEGLPFSSSDNGEAVLDPGQAPRPFNDPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGGQPDGVPGAAGSARDGSGLRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHAAGAKPARGQPLPPLPAVPPDPFKSPAAKGPLAPTDLVTDWTCGLSVLGPTDGGDL
The following text describes a protein:
Function:
Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAPHGDRKKGKGADRPGKPGLGPNRKEFKNHRKEEGEKAGGAEEEQEQQQPAPHPAALFNAADDGDFPRGGRSLLSRDEMAEARTEAEVEFEKEERRGKKKRKANASSGIDGDDDLGTLFGGATTGKLPRFANRITLKNISPSMKLWGVVIEVNQKDIIVSLPGGMRGFVRTEEVSDIALHGNSKDNEGSVCAEVVHVGQLVPCMVLQVDDDKKEGKAHKRVWLSLRLSRMYKGLSLDAIQDGMVLTAQVKSVEDHGYILYFGVSTFSGFMPKAGKETVKIESGQLIQCVVKGIDKTRSIIHLSSDEDLISKSIIKDLKGLSIDHLIPGMMMSARVHSVLENGVMLSFLTYFTGTADIFNLSSSFPSGNWKDDYSKNKKVNARILFVDPSTRAVGLTLNQHLLRLNVPPINVKVGEIYDKSRVLRVDKKAGLFLEIPSPTPSPGFVSIHDVSDKDVKNVEKKFREGSLTRVRVLGVRHLEGVALGTLKDSAFEGSVFTHADVKPGMVVRAKVVTVEPFGAIVQFSSGVKALCPLPHMSELDNIVKPPKKFKAGAELLFRVLGCKSKRITVTYKKSLVKSKLEVLASYADAKTGLVTHGWITKIEKHGCFVRFYNGVQGFVSRSELGLEPGIEAESVYHVGQVVKCRIVSVVPTSRKLYVSFTMSSNRVIQADTAKVGTIVSGVVERLTPATVVVSVNGFSKGSILNEQLADHHGQAAQLKNLLKPGHEFNQLLVLDTEGQNLVLSAKHSLINTANDIPSEISQMQSGAVVHGYICNIIEAGCFVRFLGHLTGFSPKDKAVDRPIEKLSDVFCVGQSVRSHVLNVNAESARVKLSLQQSMCSSPDCSFIQGYFLLDQKIAALKYSGPSTSHDWVKYFGIGSLVKGEVGAVEEYGVILNFKDHPDVVGLVEHHQLGGSTVKVGSSVKGLVVDLSDGVVNLSLKPELVGSVSKDGKKKKRHRAANLDLELREEVNAVVEIVKDSYVVLSVPEYNHAIGFAPLMDYNSQLLPQHHYDNGQCITVVVGSIPSSDPSGRLILLPKGSAQDSSISSSKRAKKKSDYKVGSLVEAEIIDIKPLEVILKFGVNLHGRIHITEVLEEDCSEHPFSKLKIGQKVHARIVAQAEHSAKTGRNLKWELSIKPSLLKADLEELTASEAELNHSINDIVRAYVVKVDTEWIWLTVSRKFMAHLFILDSSVEPSELKEFQQRYSVGQAVKGHIIGVNREKRLLRLKAFDNQCMLEDIDDTQKTASSIAEHTKEGDIIGGRIQRILPGVGGLVIQIGPHLHGRVHYTEIVDSWVPEPLSGIHEGQFVKCKVLAVSRQAEGSLRVDLSLRSRKLDDSTICGPRFEKINDLCPGTEVKGYVKNVNPKGCFIMLSRMVEARIILSNLSDEYVENPQKDFSVGMLVQGRVLSAEPLSGKVEVSLRRSTGSKSQKLDDISYSDLHVGDIVDGQVKRVESYGLFVTIKSSELVGLCHVSELSDEPVLDINACYKAGDMVKAKILKIDEDRHRVSLGLKESYFDSDLTDDENGNGRVPMDISRAPQMSGGFNSTLVLPGPEPRASVPPLQVSLDEYEGSDQEGDQKAHEIANGSESNVKKSDRRLKEKARKQREIEISALEERALQKDIPQTPDEFEKLVRSSPNSSFVWIKYMAFLLDLADVEKARSVAERALRTINIREEEEKLNVWVAYFNLENEYGSPREDAVKKIFQRALQYCDPKKVHLALLGMYERTKQNELADELFDRMTKRFKTSCKIWLRRIQFSLTQGKDVEYIKSVVNRALLSLPQSKRIKFLTQTAILEFKCGVAEEGRSRFELILREYPKRTDIWSVYLDQEIRLGDTEIIRALFDRVTCLSLPPKKMKFLFKKYLRYEKAQGDEERIEHVKQKALEYVEISRA
The following text describes a protein:
Function:
Plays a role in primary cilia formation. Involved in cartilage and bone development. May play a role in the differentiation of cranial neural crest cells. May act as a downstream effector of hoxc8 during development.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Membrane; Multi-pass membrane protein.
Sequence:
MADAAMSGEEKEEDGGKRTTAATPAETLGFYEPSDGSRVETKKRSLSDLSLLRFISAELTRGYFLENNEAKYKERREKVYTCLRIPRELEKLMVFGFFLCLDAFLYVFTLLPLRVLLALIRFLTLPCCGLSDGRVLQPAQVCDVLKGVILVICYFIMHYVDYSMMYHLIRGQSVIKLYIIYNMLEVADRLFSSFGQDILDALYWTATEPKERKRAHLGVIPHFFMAVLYVILHAILILVQATTLNVAFNSHNKSLLTIMMSNNFVEIKGSVFKKFEKNNLFQMSNSDIKERFTNYVLLLIVCLRNMEQFSWNPDHLWVLFPDVCMVIASEIAVDVVKHAFITKFNDITADVYSEYRASLAFELVSSRQKNACTDYSDSVSRRMGFIPLPLAVLLIRVVTSSVKVQGILAYSCVVLFYFGLITLKVLNSIVLLGKSCQYIKDANMEEKLFQPPTCQPGKTPKKAQNKSKPNQGHPPDETANTSVTSQPTKAASTAQLLVESNSDKLLTTPDAEEKDISGDNSELKQKQADKDLLDIDRFTICGNRID
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MELAFVADWPKTDANVCIKKLIDDCVLSWSCRNIVAFTAIGNPNSPEEREVYRPTIHIVDPDRPWEVCSFGNQHNDAIQALQWNMEGTQLLSADASGSVYLWQMRHHLMNDWMCIAESHLPGEPVVAIAWLRNGMKITYNVDNIDTPNMLDKFSRTRFTPSLAEFCMRPTQGWVLVTGTGLVSVTVLKDGKTTVVTERLGNSRNHIALADIAFTSTGHILIATSDGGTRCPLQCFKVMPDWKDDKLHVSTEYLPSLYMQCLCEITSRDKYPSITSVQFINKECTEQQLRSAPTEQLLVCASGSMGSCIECWTLKKEAIPLHKLFQAGSPHHRDQPTTLKWVFSSTYTDASIITSIALPKLPLKLSMNSLYTGPGMAVAVANQEGTIKLLHRSSLKACAALRYEGVINSDPGPPAKRPNFNGKHLVSMEMSATCCSMVAIDRTGTLCMFKIEPTLGQGLDQVTARAHTIAQVVHLLEYCLVTGYDWWDLLLTITPNMVDTVLDRLSDSVNRQSSSTQELLFTRLVAVKASLYRLSASGSGKAVDCYGKLLLHSTANVFKSLLRASAISSQDKGPAEKLSTLCANSTETNPDTLLKKLDSKEYVVEPATLQCLQPLIQWVADYTIVSLAAVPPPGSPTNRPGVSLMRDVPTLVMLREQRRSGAVSLMRDVPTLVMLRELLLIIRMWGRLQKNCLPVFTTTADDPDVLIPSLFRLVSQIWVHYHDKQPTELDESLIDECTLLPSQVGVPPWDLSPVTEGYTGKIHVRHGQSSFQFGTLPGRMISIATFSLGPEIYTRSLTDRLHQKFDVVRKLSLGVTPHKEIRRCSRCSCISLMPPVTQQSSTVRVVWEKRWERNCLCGGLWRTVTVHPA
The following text describes a protein:
Function:
Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
Subcellular Localization:
Cytoplasmic vesicle lumen.
Sequence:
MFRARRSRISLVFAVIFVLLIFHFSRSRSYDQPAILQVPPPPVDHHNPPFPDQNLKDPYENDNSATGSGAPPPALVEPEEYQRPPLYTDSDDSPTPSKERLDTPSNVPSQEPEFDAARLQTGAQTQNKHEDDEDIVPISHWKPMPERHPVSPEALIKLPTGQSKELPQLQAKFKDESSSDKMQRLQQLDTIKSAFLHAWNGYKISAMGHDEVRPLRGGFKDTFNGWGATLVDALDTLWIMDLKEEFSMAVDYVKKIDFTTSTKKEIPVFETTIRYLGGMLGAYDISGHKYDILLEKSVELADVLMDAFDTPNRMPTLYYKWSPEYASEFRRGDFKAVLAELGSLSLEFTRLAQLTKQDKYYDAIARITNELEKYQDLTKLPGLWPLNLDASGCRRVPGVSREPAAAGQPVRWSSDEINSTSSVSYRTRQIHEGGEPVRHDNDSFETGFPVSVDTRTPPPKQDCTGGLNDQLSGIDKFGLGALGDSTYEYLPKEYMLLGGNNDQYLNMYQKAMDTVREYLVYQPMLKNNRDVRFLATVSMTKSLDANPPGRTTFAYEGTHLTCFAGGMLAIGAKLFGLDKDLKLGSQLTDGCVWAYEATKSGIMPEAFQLVPCKKGEPCEWDEDAYYMAMDPYADKRPISHNKRSAGPEKGNWHVVATAESSSPQEDKTQKSTTTEGRHTGTTTGAGALSHEEFVTGKILNDRLPPGMTGISARQYLLRPEAIESVFIMFRLTGDPSWREKGWKMFQAVDKATKTELANSAISDVTVDNPRPVDSMESFWLAETLKYFYLLFSDPSLVSLDEYVLNTEAHPFKRPKY
The following text describes a protein:
Function:
Probable collagen protein.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MSSGDPAHLGLCLWLWLGATLGREQVQASGLLRLAVLPEDRLQMKWRESEGSGLGYLVQVKPMAGDSEQEVILTTKTPKATVGGLSPSKGYTLQIFELTGSGRFLLARREFVIEDLKSSSLDRSSQRPLGSGAPEPTPSHTGSPDPEQASEPQVAFTPSQDPRTPAGPQFRCLPPVPADMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLSTKEQVLAAVRRLRYKGGNTFTGLALTHVLGQNLQPAAGLRPEAAKVVILVTDGKSQDDVHTAARVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSVLDFLQLGALAGLLSRLICQRLQGGSPRQGPAAAPALDTLPAPTSLVLSQVTSSSIRLSWTPAPRHPLKYLIVWRASRGGTPREVVVEGPAASTELHNLASRTEYLVSVFPIYEGGVGEGLRGLVTTAPLPPPRALTLAAVTPRTVHLTWQPSAGATHYLVRCSPASPKGEEEEREVQVGRPEVLLDGLEPGRDYEVSVQSLRGPEGSEARGIRARTPTLAPPRHLGFSDVSHDAARVFWEGAPRPVRLVRVTYVSSEGGHSGQTEAPGNATSATLGPLSSSTTYTVRVTCLYPGGGSSTLTGRVTTKKAPSPSQLSMTELPGDAVQLAWVAAAPSGVLVYQITWTPLGEGKAHEISVPGNLGTAVLPGLGRHTEYDVTILAYYRDGARSDPVSLRYTPSTVSRSPPSNLALASETPDSLQVSWTPPLGRVLHYWLTYAPASGLGPEKSVSVPGARSHVTLPDLQAATKYRVLVSAIYAAGRSEAVSATGQTACPALRPDGSLPGFDLMVAFSLVEKAYASIRGVAMEPSAFGGTPTFTLFKDAQLTRRVSDVYPAPLPPEHTIVFLVRLLPETPREAFALWQMTAEDFQPLLGVLLDAGKKSLTYFHRDPRAALQEATFDPQEVRKIFFGSFHKVHVAVGRSKVRLYVDCRKVAERPLGEMGSPPAAGFVTLGRLAKARGPRSSSAAFQLQMLQIVCSDTWADEDRCCELPASRDGETCPAFVSACSCSSETPGPPGPQGPPGLPGRNGTPGEQGFPGPRGPPGVKGEKGDHGLPGLQGHPGHQGIPGRVGLQGPKGMRGLEGTAGLPGPPGPRGFQGMAGARGTSGERGPPGTVGPTGLPGPKGERGEKGEPQSLATLYQLVSQASHVSKFDSFHENTRPPMPILEQKLEPGTEPLGSPGTRSKALVPGEWGRGGRHLEGRGEPGAVGQMGSPGQQGASTQGLWE
The following text describes a protein:
Function:
Helps the assembly of pre-ribosomal particles containing 18S rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAKKDKTSVKKSVKETASKKGAIEKPSKSKKITKEAAKEIAKQSSKTDVSPKKSKKEAKRASSPEPSKKSVKKQKKSKKKEESSSESESESSSSESESSSSESESSSSESESSSSESSSSESEEEVIVKTEEKKESSSESSSSSESEEEEEAVVKIEEKKESSSDSSSESSSSESESESSSSESEEEEEVVEKTEEKKEGSSESSSDSESSSDSSSESGDSDSSSDSESESSSEDEKKRKAEPASEERPAKITKPSQDSNETCTVFVGRLSWNVDDQWLGQEFEEYGTIVGARVIMDGQSGRSKGYGYVDFETPEAAKAAVAANGTKEIDGRMVNLDLSNPRPANPQPYAQQRAGNFGDQLSEPSDTVFVGNLSFNATEDDLSTAFGGCGDIQSIRLPTDPQSGRLKGFGYVTFSDIDSAKKCVEMNGHFIAGRPCRLDFSTPRTGGGSRGGRGGFGGRGGFGGRGGFGGGRGRGRGGARSGNPNRGSVAPFSGNKVTFD
The following text describes a protein:
Function:
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism.
Sequence:
MLFLGMLKQVVSRTAQSKASSCRKLVLPWQFLGSSQHRVPANVNFHSTSFSEAEPPRVLITGGLGQLGVGLANLLRKRFGKDNVILSDIRKPPAHVFHSGPFIYANILDYKNLREIVVNHRISWLFHYSALLSAVGEANVPLARDVNITGLHNILDVAAEYNVRLFVPSTIGAFGPTSPRNPTPDLCVQRPRTIYGVSKVHTELMGEYYYYRYGLDFRCLRYPGIISADSQPGGGTTDYAVQIFHAAAKNGTFECNLKASTRLPMMYISDCLRATLEVMEAPAECLSMRTYNINAMSFTPEELALALRKHAPDFQITYCVDPLRQAIAESWPMILDDSNARKDWGWKHDFDLPELVATMLSFHGVSTRVAQVN
The following text describes a protein:
Function:
Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MSRAGRQLALLLCSCCVAVAIPGGLAEEGCPAEPHQASRYVAAVYEHQSFLSPDPLALTSREQALELMHRNLDVYEQQVTTAARKGAQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPRSVRWNPCLEPHRFNDTEVLQRLSCMAMKGEMFLVANLGTKQPCHSSDPGCPSDGRYQFNTNVVFSSNGTLVDRYRKHNLYFEAAFDTPLEVDHTVFDTPFAGKFGVFTCFDILFFDPAVRLLQDSEVKHVVYPTAWMNQLPLLAAIQIQRGFAIAFVINLLAANIHHPSLGMTGSGIHTPLKSFWHHSMDSPEGHLIIAEVARNPPGLISAGNATGKTDPFHRKFLQLLAGDPYSEKDAQDVHCDAAPKSTTNASPTFNSEMMYDNFTLVPVWGRDGHVHVCAHGLCCHLLYQRPTVSQELYALGVFDGLHTVHGTYYVQVCALVKCGGLGFDTCGQEITEAMGMFEFHLWGNFSTSYIFPMLLTSGMMLETPDQLGWESDQYFLKKRGLSSGLVTAALYGRLYERD
The following text describes a protein:
Function:
Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
Sequence:
MAEEDLIFRLEGVDGRPASRAGDSDTDSDDDEEGYFICSITDDPGAHQNVNFKVNNCHSNLAKSERYGSSGSPAGSFHFKEAWKHAIEKAKHMPDPWAEFHLEDVATECATRHRYNAVTGEWVEDEVLIKMASQPFGRGAMRECFRTKKLSNFLHTQQWKGASNYVAKRYIESVDRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKERPGRPLFHLEHYIEGKYIKYNSNSGFVRDDNVRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTERGTDFGDGNLGVRGMALFFHSHACNRICKSMGLTPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSPRVRTLSGSRPPLLLRLSENSGDDNMSDVTFDSLPSSPSSATPHSQKLEHLHWPVFSDLDNMAPRDQDPLDNHRDSENGGDSGYPSEKRGDLDDPEPREHGHSNGNRRYESDEDSLGSSGRVCVEKWNLFNSSRLHLPRPSAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEAGRFCEKDEEWDRESAVFHLEHAADLGELEAIVGLGLMYSQLPHHILADVSLKETEESKTKGFDYLLKAAEAGDRQCMILVARAFDTGQNLSPDRSQSWPEALHWYNTALETTDCDEGGEYDGMQDEPRYMLLAREAEMLFTGGCGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYEKAEEAWAQMEE
The following text describes a protein:
Function:
Receptor for the C-X-C chemokines cxcl11.1 and cxcl11.6. Promotes macrophage chemotaxis to sites of bacterial infection.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDNSTTAAEVSAPTDYDYNSTSYDDDNPYAAPCSLTETWNFLGRFAPVAYILVFILALVGNILVLCVIRRYRQSRHSPCSFSLTDTFLLHLAVSDLLLAATLPFFAVEWISEWVFGKVMCKITGALFSLNVYCGVLFLACISFDRYLAIVHAINISWRRKTCHAQLACAFIWVICLGLSMVDMHFRDLVEIPGMNRMVCQIVYSEQYSKQWQIGMQLVSMVLGFILPLLVMLYCYLHIFKALCHATRRQKRRSLRLIISLVIVFVISWAPYNALRMTDSLQMLGVIVKSCALNNVLDVGILVTESLGLAHCALNPLLYGLVGVKFRRELAQMCKAALGPQGCLGLVGWANGRGSSTRRPTGSFSSVETENTSYFSVMA