lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation. In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu. In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp. May act as a tumor suppressor.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MNICNHLRVKKQCDGDVSCTVFRIEPLHERWDLEEACAQLLNDQWQRSMGARIHSLHQSSHDYPVCLLLLQGERQTQHEKVIGHARLSRVLGSRSLLVESVVVCKSLRGKGYGRILMEGVERYAKGRGCTRLCLTTHDKQHFYAHLGFVLSKPVQSVGTLASFMPMEILHRFCRTAENEEEERKFKVTNHAKSTPSVLPPAPPPPPPPPQIYSSPPPPQPPISCPPPPPPPPPPLFCAPVSPTLEQTPYTDNSGLPIFWMHKDI
The following text describes a protein:
Function:
Positive activator of the genes for pyochelin and ferripyochelin receptors.
Sequence:
MTITIIAPPQADAAAPAPGNRPGVAHIDPNMKLVTGTFCSASEDWFEEPLERGLRLILVQSGQLRCRIPGQPEHLIEGPSLCTIANDGDFTSAQIYGTDKPLRYTIVQLGVEALDSRLGWLPEQLIRRPGGDPRIMSCPAPRAMQALASQIATCQMLGPTRDLYLGGKALELAALSAQFLSGEGRPVEEPRITCSEVERIHAARDLLVGALQEPPSLDTLASRVGMNPRKLTAGFRKVFGASVFGYLQEYRLREAHRMLCDEEANVSTVAYRVGYSPAHFSIAFRKRYGISPSEIR
The following text describes a protein:
Function:
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MSSHGEVSWETLRRQIRSLENTLESEITTYAKLCTSVSTAYSSNGKLSERTITESREVEERIEDNLKQLSLQVDQIYRLLQTSSAAPTGSMTHACNRHKEVLQEYERDFKRTRTSLRECEQRASLLSSVRSEISSFKSSQIASEQDRHLNDRSSINSSHRLADDVLGQAYETRYQFSNQRRTLFNSNSRMGSVIATVPGVNSLISMINSRRRRDTLILATVAGGCTFMLLLLTFR
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.
Sequence:
MFDYILSLGGTVFVPIIMIVIGLIFRIPWLQAIKAGVTVGIGFVGMGLVIVMAIDSLSPPIKVMIERFGLALHVFDVGAGPASGVGYATAIGAMIIPVIFLLNVAMLVTRLTKTMNVDIYNYWHYAITGTVVQLMTGSLIYGVLGAICHAALSLKMADWTAKRVQNIVGLEGISIPQGYGSSSVPLFVLLDAIYEKIPFMKGRNIDAQEIQKRYGMVGDPVIIGVVLGLIFGLAAGEGFKGCASLMITVAAIMVLFPRMIRLIVEGLLPISDGARKFFQKYFKGREVYIGLDTAVTLGHPTTIAVGLLLIPIMLILASILPGNKVLPLADLPVAPFFICMATVIHRGDLVRTLISGVIVMITVLLIATQFAPYFTEMALKGGFSFAGESAQISALSVGNMFGWSISELMSLGIIGVVVAVGIVASVVLFLRKRELSE
The following text describes a protein:
Function:
Odorant receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWPNITAAPFLLTGFPGLEAAHHWISIPFFAVYVCILLGNGMLLYLIKHDHSLHEPMYYFLTMLAGTDLMVTLTTMPTVMGILWVNHREISSVGCFLQAYFIHSLSVVESGSLLAMAYDCFIAIRNPLRYASILTNTRVIALGVGVFLRGFVSILPVILRLFSFSYCKSHVITRAFCLHQEIMRLACADITFNRLYPVILISLTIFLDCLIILFSYILILNTVIGIASGEERAKALNTCISHISCVLIFYVTVMGLTFIYRFGKNVPEVVHIIMSYIYFLFPPLMNPVIYSIKTKQIQYGIIRLLSKHRFSS
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
Subcellular Localization:
Nucleus.
Sequence:
MNRSGKRKRRKERGDEAADDDASPSSASFDRHVFPVLLAAAQTTSQNRNSCSPAALAARLLRRVLSRPRQMLSPLPDSLVALLPRLLSTSCSSVAALSCEVLGAAALRSMEAGEVLASDSCIASGLARALGSRSQRVTEAACNSIMDLSASSVGRERLAGSPVLPRILYVFSQVESIREFVDSRTTKYPKRDTEANKIFYLITDTVVLLVNSCKLDKLQSIQKELVRTALSLLHKVWKKVQLLRSSADCNNGKNQLQSREYEICKAIFRLSIDLASPTCLEPDVVRESIFGQTESSFENFVLAYWERSPNLYRRKQNTRNDDPVFAALHSAFNLGAAPDAIIESFMEGLVSCPAIASDELDINSFLQEVHDSLGDAIMYRQDIRVLRTQDLSDQTSRGCVMEEHFFDDGTVFLDEDTFTKKCKHSFKNGYSIALRGMEFRFAKVAAIASALADLFGQPSVGANIYFSPARSQGLARHYDDHCVLVWQLLGCKKWMIWPNPKPLLPRLYEPFDPLDGTLEDNSGRVEVLHEGDMMYIPRGYVHEAHTDVGEPQINAHGGYSLHLTLAIEVEPPFEWEGFAHIALHCWVEKQKLGGSQFDKSSAKKETSLFAIVLHVAIRLLSSNDPIFRKACMVAAKLPSPSACATAHLKALRSSQRSTFDEIIRNIEKNCSFKEALESIKLAVQEKNDEHFQWMSWLRHLPQEGDADLRIDFCNILEALEELVEAFSSDPEQALVGFTGFKSRFCRCVVYEYEDACGSFETLLQMYRTTRNQYMRGMLALHGAHVS
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Subcellular Localization:
Nucleus.
Sequence:
MDSQAPIDDLLLDIVDNAWRMEVLPFDQILVPREKLPDPEADGGDSHLTVSEQEQKWTDLALGSLAPDAALIDQLNITSIXPRTVSPRASATASPTNLLAPQAQLLTPRQHD
The following text describes a protein:
Function:
Involved in the regulation of gamete interactions during the double fertilization and to prevent multiple-pollen tube attraction; mediates the redistribution of the gamete fusogen HAP2/GCS1 to the cell surface after secretion upon sperm arrival.
Subcellular Localization:
Cytoplasmic vesicle. Secreted.
Sequence:
MAIKNNVFFIILVLMMTCHRAYATESRSYDLNNNNMNNPNLGPCYGPDSGQAYYECFKAIQGLNSCSNLIAKFFTVSRSDIAQCCSAIDRVTSECSSWPDANTYTDPLPAFGYTDQELDMLVSYCSRASSPAASSAPAPALAPNLIY
The following text describes a protein:
Function:
Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
Subcellular Localization:
Nucleus.
Sequence:
MYMESENREAEELDLLCREACDTPELTQEEELDFSPDDEPPPFAPPNVTSAGISFAARLPPDVLHHQPAQRDQESQRQEAATNINWLAELAIIATSPQSPLMPKTTHHTHRKSPQQHAVLMTDRPDRCMHNYARPPPPSSSPPLTHPRHRQSGLISGGNGLSASSHFSSSQRLADPPALSKSWPTTAWHCFMKGTRVRLSEDARREWRLAEDVPSDDSLQEDRKLKEVLNVLLGKDTTSLCGLRLVQFEETTTVDRSAENMVHMVFRTEVADREISAECALDHPFFVRDKGWCSFHPGLTYTRYGLPCQEIEYGDVCIPPPHSGSSPDQEEDSDSVFDEFSAVNFLSTLAKQRRELQTSPVRSPPSSPTKRQRNNSGNSDQPVKAKRPMNAFMLFAKKFRMEYTQLYPGKDNRAISVILGDRWKKMKVEERKVYAQEAKVLAERHKKIHPDCWKRKRSTSASSM
The following text describes a protein:
Function:
Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
Subcellular Localization:
Cytoplasm.
Sequence:
MSYTADSLKAELNARGWRLTPQREKILTIFQNLPEGEHLSAEELHHRLEEEREKISLSTVYRSVKLMSRMGILRELELAEGHKHYELQQASPHHHHHVVCVQCNRTIEFKNDSILKQSLKQCEKEGFQLIDCQLTVTTICPEAIRMGWPSTLPSNWACTRSISLA
The following text describes a protein:
Function:
Involved in the export of flagellum proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSTRDLSVLISVVLIVAMLVIPFPPWLLSILIIINISLALIVLLTTMNMQEALQFSIFPSLLLLLTLFRLGLNVSTTRSILSHGEGGKVVETFGNFVVGGNVLVGLVVFIILIIIQFIVITKGAERVSEVAARFTLDAMPGKQMSIDADLNAGMITEQEAKHRREKVAREADFYGAMDGASKFVKGDAIAGIIIVMINIIFGIVIGMLQQGMSIQEAASHFTMLTVGDGIVSQIPALLISTATGIVVTRAASEGNLGHDITGQLFAYPKLLYVAAATIMLLGIFTPIGILLTGPLAGLLAFGAYTLSKSGKEKEEVDEILEEEAEVDELKSPESVVQLLHIDPIEFEFGYGLIPLADANQGGDLLDRIVMIRRQLALELGLVIPVVRIRDNIALQPNEYRLKIKGNEVAKGELLLDHYLAMSPTPEDDLIEGIETVEPSFGLPAKWISEAVKDEADMLGYTVVDPASVVSTHITEKIKQHAHELIGRQETKQLIDHLKESYPVLVEEVTPNPLSVGDIQKVLAKLLKEKVSIRNLVTIFETLADYGKLTTDSDLLTEYTRQALAKQITAQFAKENEVLKVVTCSGRVEKAIADGVQQTEHGNYLSLEPDISESIVRSVAKEAEQLSLRQETAILLCSPPVRMYVKQLLERYFPDLPVLSYNELEANVEVQSIGVVDI
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates 60S ribosomal protein L12 (RPL12A and RPL12B) at 'Lys-4' and 'Lys-11'.
Miscellaneous:
MISCELLANEOUS: Present with 768 molecules/cell in log phase SD medium.
Sequence:
MEGKVDVLLTWLKKSDKFYIAPNISICESPETGRGIVLSHGSIRKNDIIVSVPSSKQLNFHTILYHISKFNKELNIPGITIDRKPINYEDNIIEAENKAWADPRYGLYSELSKEFLLSLSSFQLVSFYILVENFLLPKWTHNEIYSDWKPFFDVWPSMEELRSIPAIWNCDPNSRYHSLIEYLPAASRKHMARISGLVREDWETISEVVLKWNEIYGSLSCTKNSDKFTSDELFSLFVHVYFIINSRCLYAKIPLKIEDSPSNFTLVPYVDFMNHICESDLHCYPQLSPQLRSEGENIIGIGQFTIRCGDHLYDNINEELFLNYGAHSNDFLLNEYGFVVDGNKWNYLDISDEIIELIDDDKKEVKTFLLEHDYWGDYTINETDISYRIFVALNYYVTRDERRVRKFIEGYISEDYFKPKISSVLKELLVSLTAKYTKTLSELTEKVSNLENNLCLQNLITIYKGYIKILTQHLQDLQS
The following text describes a protein:
Function:
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Subcellular Localization:
Nucleus.
Sequence:
MGKDDIVLLVSSLITLIAIGVSLVMVNQLAEEIADIGESSLRDLKQFKEYADDAWTIMVAEVNEKATFSEKEQFEEIIRRTKRQESSGGYVQPPQPPVSPPRMVPSIPRPTVPRPGPTYLPPHPMPVHVPAPSTGVNMGNIGVGSIPRHTGGPTCSACAARSRSCPSGPPGPPGPPGYPGEDGIPGQDGAHSHSNYGPGIEMGSGGCIKCPPGPPGFPGPDGMEGPPGMPGFPGGSTGSMGYGRPGLPGPPGDMGMPGMPGMPGQPGAPGAPGGGGGYSRGRPGPPGPPGRPGMMGSPGSPAYGGGAPGLPGPPGPAGNPGYKGPDGQPGGSGRGGGPGGDGAYCPCPRRNTRDLKTLDADSGPSGKMTIRDGPNVQRVEGSVGSSQRMKPVWRTSSNQSFMERSMDEIWLDEDSVDWDDDNTASKAGSSAAVSANGPDSAFKGIPRETAFDNKKRFSFGLNEQPTKNSAMKSPIKSRVSPTKSLLKFQRRSISQPVLELLTLSEDEAAPSLELLKKAKRAKKSTKTQKPVPSSLPSSPVKKTQGGKKKEKDTTVISEFHAVYCLVSRSQNKAHKGRCYIGYTKDTNRRIKQHNGGKDVGGAKKTDGRGPWDMVFCVEGFPNQVSGLRFEWASQNPDKSRVLKDRAIKKEKKETPLAFRVRVACHLINSEPWKRLALSFRWLIPSLKMPFPSAISPPEHVSVKEGLLADEKERTIRLGRGEGEYVRMKSCHICDDDISRVEEMVLCIATQSCVGTFHLSCLAKKGLEKSGEWKTQLFPVAACCPVCGGSYRWGDIVRAQHDTVEVMKAHPEQETMEGMIPKMKIRMIV
The following text describes a protein:
Function:
Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
PGQPKALNRPTVHDFCTSDGHTASLSLADGEPGPPRATPLPATGSAPASLPALGDSHPGQTEPPALGICDWWRCRALSCRCDQAAVSTGEEDPLPRAEEDEEATWERAAAGPGRSGAGWRLCSFPCCCLWEPGVSTEESSADSDPLPRLPGPPCRGGRKMPVKKKRKSPGVAAAVAEDGGLKKCKISRCDCTEKLQNKFDFLRSQLNDISSFKNIYRYAFDFARDKDQRSLDIDTAKSMLALLLGRTWPLFSVFYQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDEFVEWQKVRQTS
The following text describes a protein:
Function:
Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MGKSTKDKRDIYYRQGKSEGYRARSAYKLLHLNEQYGFLGGAEDYALDAGAASTCASSSDSANAPKTTSEKRFQTPTRVVDLCAAPGSWSQVLSRRLASVPGSHLVAVDLQAMAPLPGVTQIIGDITTPATADAVSTALSDGPLSNSTCVKGKGKGKARAQLIVCDGAPDVTGLHDLDEYLQSQLLLAATQITFRLLEIGGTFVAKIFTQHPQAGLGASLGNMDLKAARPATSGALLADQLRTFFDRVDIAKPRSSRLGSVEHFLVCLGFKPPQNLPAGLVGSLAGTLSSTSTEEEARDDLVRYAQKLRSELQRPDVPTSGMAQSKRELSAILSFVVHGDLSGFDQ
The following text describes a protein:
Function:
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.
Sequence:
MNLYLSLHEQYFINTIKKKLSGKEEDTILTSKHESILLSAIFWVLSSISLINKKRETIDEVLSKDFIEVIYMLVMKCLHRRKIKDEYIYKLKKETYISSNEDIKKKKKKKFIVTGFSPCNKKNVYEANIISTLSAIQILFLLNKTDENSISTKTLLEIYNFVIFLFDEEKGYFHFSLKSVQYKFDGDMRFMFCSLCTLYLLNKLFKERNIYVNNINNNKCIHWIINCFNIDGGFSNLPGSESHAGTTFCAIHSLKLLKNEKGKTYFSYNPIMKKKLIRWLCERYDNFGINGRVGKDHDVCYSWWVLSSLSSLNVNLGKAFNVNIIINFILKCQDKVNGGFSRIGQDEYNINKKCMNYFKNENFFFKQTDQFHSFFSLCALSLIYYNIHYYMKKERLKKYELFDQISIPKHINDVLSNMANIHEAFAMPRRLIQ
The following text describes a protein:
Function:
Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell. In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localized in specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria.
Sequence:
MSPEEWTYLVVLLISIPIGFLFKKAGPGLKRWGAAAVGLGLTLFTCGPHTLHSLVTILGTWALIQAQPCSCHALALAWTFSYLLFFRALSLLGLPTPTPFTNAVQLLLTLKLVSLASEVQDLHVAQRKEMASGFSKGPPLGLLPDVPSLMETLSYSYCYVGIMTGPFFRYRTYLDWLEQPFPGAVPSLRPLLRRAWPAPLFGLLFLLSSHLFPLEAVREDAFYARPLPARLFYMIPVFFAFRMRFYVAWIAAECGCIAAGFGAYPVAAKARAGGGPTLQCPPPSSPEMAASLEYDYETIRNIDCYNTDFCVTVREGMRYWNMTVQWWLAQYIYKSAPARSYVLRSAWTMLLSAYWHGLHPGYYLSFLTIPLCLAAERQLESALRWRLGPGGQKAWDWVHWFLKMRAYDYMSMGFVLLSLRDTLRYWASVYFCVHVLALAALGLGLALGRGGPGRRKSGAPAPSPASGKLREE
The following text describes a protein:
Function:
Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24 (By similarity). Removed from centrioles by TTBK2, leading to initiation of ciliogenesis and localizes only to the daughter centriole in ciliated cells. In cytotoxic T lymphocytes remains associated with the mother centriole during docking of the centrosome at the immunological synapse upon target contact. Recruited at the distal end of the mother centriole by MPHOSPH9 (By similarity).
Sequence:
MEEYEEFCEKALGRAQEASLSTGSFLPAQAESVSLIRFHGVAVLSPLLTIEKRKKIQEEKQKALDVQSRKQANRKKALLTRVQEILENVQVRKAPNASDFDQWATETIYSNPEVTDLNVPVRVPNSLPSPTEHCTSVKLEKITGLLPVNNEDQQTPKRVGLPGDSEVSGSLRQCESPESRQAEDGAALRLSSASPQETIISDVLGKEEQDPSCLAEVTPDPYIMSLQNLMKRSKEYVERELSSRSLRNSLKRSVNETHSDRENDAAKASDCVKEKAPPMPIGRHCGSAIPDKPSLNKSNVLLQGASQASSMGTAGLASFSKIDLPAGAAPPAAPDAGSDFTVIPTFVTENKVKSLKGPYAKLPSPEPSMSPTMHRRHSRSASACQILINNPVNACELSPKGKEEAVDRTAPAAAETTNESETVPKSPTDLTGVCSSNVSATKITSESTREMVVGKPSQRQQALGAHLGNNVTVERSAMEGPFIADDRGAQKVDGTCMAVPKLHELQPSSQCVSSQTLEDVCELKSASLLAKNSCNLQMELNKSYDVKHPSPLLTQTQTSRQQMDTPPVFRGNEQFVDNSFEKVKRRLDLDVDSLQKENCPYIITAGVAEQERDRLLERRYPKGFVHINKNKMLETSPKEGQELLKSKMLAFEEMRKRLEEQHAQQLSLLIAEQEREQEQLQKEIEEQEKMLKEKAVTTDVSDLNSALEWRQRTDSALLETMLSQVDSLQTSNNSGFITSALQYSFGSAGEAPFYLWGSLTSGVTRVSGTRPCGRAQAKWSQVFNPEIHAKFNKITAVAKGFLTRKLMQTDKLKQLRQTVKDTMEFIRSFQSEAPLKRGVVSAQDASLQERVLAQLRAALYGIHDIFFVMDAAERMSILHHDREARKEKLLRQMDKMKSPRVALSVATQKSLDRKKFMKVAEMGMPNKKFLLKQNPSETRVLQPNQGQNAPVHRLLSRQGTPKTSVKGVVQNRQKPSQSRVPNRAPVSGAYAGKTQRKRPNVATI
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MADANQNIICAPDDCAIKISKWKVREGFPVTSGSIILFYEQLDGSDKEVKRLKATKSGVVKRRLAREGATVAKGKPVLELGQCSHTTVIKDMCADCGADLRQDEPSSSSSKASVPMIHSVPELKVTETLAKKLGQADTERLLSDRKLVLLVDLDQTLIHTTNDNVPNNLKDVYHFQLYGPNSPWYHTRLRPGALEFLAKMHPYYELHICTFGARNYAHMIAQFLDKDGNFFSHRILSRDECFNATSKTDNLKALFPCGDSMVCIIDDREDVWNMASNLIQVKPYHFFRHTGDINAPPGMSKNELDGKGVDFKELMSQSQKGKKSKEADDEGRPPTPKLQASTGGGKQQPCEKSMPEHVLDDNAEEEGESTAAVEKSNPEDTSDKGEATATKDEKEAVEDAVPTSTDNSCTVEDGKEKEIESKENEATAKQESDAGKETREGEAENEEQPQEHQTPDMKVKAETEAETDATAETDATAKTDATAETDATAKTNAKAETETETEAKAEPEENADGAEQVDKITTESDGKSKAAAKEENSSARNTKQEKELIELEDPDDYLLYLEHILLKIHETFYEEYDKSKTISDLKQLIPQVKARVLVGAKLCFSGLIPNNVKLEQSKAYLIARSLGAAVTQNLEPTTTHLVAVTIGTSKVNNARKNPKIKIVTPEWLWSCAERWEHVEELLYPLKASNPAKMRQPPPHCHSPEHAVNYGAVVKSREEPKFMDTVNPLLSFSNDDLDAMNNDFDDFFESDDSSSDDEPVDIENPPMEKALRKRKRVEEIETNRGRHNIFRKRVEEEQEKEENRRILKYDNPENNDENSQTNASSEDEDESPSAKFRRGENLPSDLDMGSNSEGSDEPIDDVDDGDWNMMGAALEREFLGLDD
The following text describes a protein:
Function:
Transcription factor involved in cold-regulation of CBF genes and in the development of freezing tolerance. May be part of a complex network of transcription factors controlling the expression of CBF genes and other genes in response to cold stress. Binds to the MYB recognition sequences in the promoters of CBF1, CBF2 and CBF3 genes. Involved in drought and salt tolerance. May enhance expression levels of genes involved in abscisic acid (ABA) biosynthesis and signaling, as well as those encoding stress-protective proteins.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing MYB15 have improved drought and salt tolerance.
Subcellular Localization:
Nucleus.
Sequence:
MGRAPCCEKMGLKRGPWTPEEDQILVSFILNHGHSNWRALPKQAGLLRCGKSCRLRWMNYLKPDIKRGNFTKEEEDAIISLHQILGNRWSAIAAKLPGRTDNEIKNVWHTHLKKRLEDYQPAKPKTSNKKKGTKPKSESVITSSNSTRSESELADSSNPSGESLFSTSPSTSEVSSMTLISHDGYSNEINMDNKPGDISTIDQECVSFETFGADIDESFWKETLYSQDEHNYVSNDLEVAGLVEIQQEFQNLGSANNEMIFDSEMDFWFDVLARTGGEQDLLAGL
The following text describes a protein:
Function:
CDK-activating kinase that may control G1/S phase progression. May control the rate of cell differentiation to accomplish proper development of organs, or in response to a changing environment. Forms a complex with cyclin CYCH1-1 that phosphorylates CDKA-1 and the C-terminal domain (CTD) of the large subunit of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MASGDGGDDAGVKRVADRYLKREVLGEGTYGVVFKAVDTKTGNTVAIKKIRLGKYKEGVNFTALREIKLLKELKDSNIIELIDAFPYKGNLHLVFEFMETDLEAVIRDRNIVLSPADTKSYIQMMLKGLAFCHKKWVLHRDMKPNNLLIGADGQLKLADFGLARIFGSPERNFTHQVFARWYRAPELLFGTKQYGSAVDIWAAGCIFAELLLRRPFLQGSSDIDQLGKIFAAFGTPKSSQWPDMVYLPDYVEYQFVSAPPLRSLFPMASDDALDLLSRMFTYDPKARITAQQALEHRYFLSVPAPTKPSQLPRPPPKGDSGNNKIPDLNLQDGPVVLSPPRKLRRVTAHEGMEVHMHRADRTEEHPSGARHMDDMSSQSSRIPMSVDVGAIFGTRPAPRPTLNSADKSRLKRKLDMDPEFGYTE
The following text describes a protein:
Function:
Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA.
Sequence:
MTRPIQASLDLQALKQNLSIVRQAATHARVWSVVKANAYGHGIERIWSAIGATDGFALLNLEEAITLRERGWKGPILMLEGFFHAQDLEIYDQHRLTTCVHSNWQLKALQNARLKAPLDIYLKVNSGMNRLGFQPDRVLTVWQQLRAMANVGEMTLMSHFAEAEHPDGISGAMARIEQAAEGLECRRSLSNSAATLWHPEAHFDWVRPGIILYGASPSGQWRDIANTGLRPVMTLSSEIIGVQTLKAGERVGYGGRYTARDEQRIGIVAAGYADGYPRHAPTGTPVLVDGVRTMTVGTVSMDMLAVDLTPCPQAGIGTPVELWGKEIKIDDVAAAAGTVGYELMCALALRVPVVTV
The following text describes a protein:
Function:
May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis.
Sequence:
MFRPISVKLETVDEYLQQNDYSALELYLKKEFRLEKDETGVPLKIEFSTQAVDLLHKILKTLSEQSLSKNHEGIIKELFRSLRNYVINSDVQNYLVNDENFLPNVSNFMNLQSEVIQNAFQIILQFLFNLIISNKSAVDRVYDVFYPTILSLLKDKKNIYETSALLYNMSLYKELNMDFDTYSFLLELYDSHNSVEYLYFMLEKLISDCNFWNYYLKFESNKRAAVLGVIRDKQIKGEALNIPVTGLKVLTNQFVASGNIIFQTVQNKDSSLEAYEISQLVQVISSFCSNEDYLKVLQSDKDLLINSGVLLINIHRLGKESENCFTSIQNLSEIREPNKNIQEHPAFGFKADLIRIIGNLCWKNKIMQDLTREAELIPVILDCCNMDARNPFIMQWVILAVRNLCENNMENQKIIAELHQQGTVSSSVLQELGVTLESDGDRAIKIVSLDSLRKQK
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAQSVPPGDIATQPGTKIVFNAPYDDKHTYHIKVTNSSARRIGWAFKTTNMKRLGVDPAAGVLDPKENALIAVSCDAFAYGQEDTNNDRVTIEWTNTPDGAAKQFRREWFQGDGMAQVASCLSLARGTMAPKKFKEPSIFRSADMSLCQLFLQTDAAYQCVTELGEIGMVQFRDLNEEMNTYQRKFVNEVRRCDEMDRKLRFIEEEIVKDNVFITETTDPIRAPQPKDMNDLEARNIHPHEFVATFEKIEEELLEINKNTKGLKDSHVQLWEMNQVIEKVKMMLDAGHNRHHASSVIQEAAHHPGLFDDEGKERGGTELKLVTGVIRRDRVRAFEQFLWRMCKGKVFMRTHDCDGEHDLFDGLEEKSVFILFFSGDQLAQRVNKICLGFHARLYDCPEEPHLRLSMHKQIDERLADLNNVIEKTLEHRKRVITAASNSVYAWKIKVLKIKMVFHTLNMFSIDVTQKCLIAECWIPTNDLDDVRVALRQGTIAAGSLVHPVLNEMEHHETPPTHFTLNKFTQGYQNIVNAYGMADYKELNPAPWCIISFPFLFGVMFGDVGHALIMFSFALMFIIFEKKLEAMKIKDEIFNTFYSGRYIVLLMSMFSFYTGFIYNDIYSKSINIIGSSWATGANNNSCWEWQGLKDSTTGLDYRDWEKTAAKNNQTFEIMLDPIYCYDKETGPYIFGLDPVWNLASNKLTFTNTMKMKSAVILGIMQMTFGLFVSLGNHIYNGSLVDVFFMFIPQMLFLGCIFIYLCVQILVKWIFFPVDAAWVFGRFYPGSNCAPNLLIGLINMFMMTPRTDGFGEFKNTSAPYNIGDDVNLLDFDNDPNCGLAFWYPGESIAEKVLLVVAVVSIPLMLLVKPFYIKWRSVTHL
The following text describes a protein:
Function:
Participates in the breakdown of the egg envelope, which is derived from the egg extracellular matrix, at the time of hatching. Thus allowing the newly hatched fish to swim free. LCE solubilizes the egg envelope only after it has been swollen by the action of HCE.
Miscellaneous:
MISCELLANEOUS: In medaka the hatching enzyme system is composed of two distinct proteases, the high choriolytic enzyme (HCE), of which there are two isoforms, and the low choriolytic enzyme (LCE).
Subcellular Localization:
Zymogen granule. Note=Stored as proenzymes in the zymogen granules.
Sequence:
MDLLAKASVLLLLLLSLSNAQTDNMEEAENGSSKEEIDESELEDVSSIIFRMNNNSMEELLEGDLVLPKTRNAMKCFGAPDSCRWPKSSNGIVKVPYVVSDNYESDEKETIRNAMKEFAEKTCIHFVPRNNERAYLSLEPRFGCKSMMGYVGDKQVVVLQRFGCIKHAVIQHELLHALGFYHEHTRSDRDQHVKINWENIIKDFTHNFDKNDTDNLGTPYDYGSIMHYGRTAFGKDRKETITPIPNPKAAIGQTERMSDIDILRVNKLYKC
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MGISQEPTEPVMGNQDPDQLHETILTLTLEIIYLLTGEGYSVTKKSGDDMPLPQSCTDCMLGGACRHHVTSATVAPPPGSVIQKENAKKILELMSNIIQLLTGEVAIRCEDVSLYFSLEEWQYLKGNKSRYREVIKENWEQLLPLGGEYGGGRDSEWDVGADVRNANKPDKTEAEEADSWGEGNPPNPDISPTDPQTLTNCISHGIKEESWEEEEHCEWNTDPPTEQIQGTDPPTDTVGSHLNISQSDNHSPSGIKEEQRSGSDPTSDTRGSSLNNSLSDSNRIKEESDSWEDCTNWTMNAITEPGSSVYSNLSEHSISHTVRGETASWDGGNPSDCSMYVLVGQGTEPSSKVMGSNPKSSLCLSDGSSCTNGGLTSNKGASDSKFNPMGTPRTDPAAHILGPKLRAADASGNEHSPYVNIRVLATTQPGTPNPKMMYTCSTCEKPFTSRKHCERHQRVHTRETTFPCTECGKVFTQRSHLTAHSRMHSGDNSFTCSQCGKCFLFQSDLNRHVITHTGEKPFTCSECGKRFGHLYSLKRHLIVHTGTKPFSCTQCGKCFGHQGDLNRHGLIHSGHKPFSCTRCGKCFWLQRDLTRHVRTHTDLSQGQMIDLGH
The following text describes a protein:
Function:
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Subcellular Localization:
Cytoplasm.
Sequence:
MDAVTVYHGKISREMGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSARSPQAPTGRRDSDICLKAP
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MVVGLILRAGVVYAVVMVTKNYGVWESPNKTQDVYDETVERIEPYADQARRKLNICPPRPPPEGEWSFFGIYYYNKLVKSVFDLLSVFPAGLAAFLEKVPSYVNAFNETIQKYIKESQSKKKEITISKGQLDETPLVRPPGLVPPHCKDKNCPKAPLIPPGCDRNRDSFIYEPRLPKKPPCECAKCKQRQAENWKDNKRKCPRIPSSEAKCRCGEGPQSEARSEPIKSCKQCRKTPRETAT