lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MNEWNGQQANKKKTEQATTTMTSPHQHTPVNFAQQPYLIRHPPLTQNRHPNSLHTFLAKIDYLATAADSPACPPTKQNLSHCPEIAVEIIKSLYSFAFEPEWATYFFPITAFNPINQPASSPSSPSPSSSSSSSTQDQIPIISLPDINPSFSLTSLQGEEAVEYGENRRGKPCGHVFQKGEGVYHCSDCGIDPTCALCARCFLASDHTGHDVTYSIHANGCGCCDCGDEEAWKTDIKCKYHSLSTDHPSPNIPLPPDDRTPSPQITSKLQPLPNHCKDVIEEIVAIALDFLLITVDRSPEDMRPPANIDAIYHELSRLEENAYLGLPRSSPSLPDNSMDIDLPFSHHPTSLQLQHQAIANSMEEAGKSSITGGLLSAFLGGRATDNKGKGKITDSTGANPNSSVGTTASSFGLTAGTAGRFNPSNHPYQSAGNTTQGSSRAAEHWSTWSHFPTPIKPTDHNLRGSGPWGVVLWNDERHSYAQVIDQVSKATGCTRAEALRIANTIDTKGREVIQVSSDPSVLLQTSKTISQIDLTVTVRTTHDLFCEQIADLIINFLVDLASCRIYNVSPEDESWLKSLITRKLRERPALGYEGGGRSRFARLLLNDVKLWKEARDKLKSLYISLLALGQTVKLELGVLFASVFPQLIEYNFLVDREPEHNILLFSLQIVTVPSVIVILVKEHGFLKMIIDLLYSFFTHQFLPAGVPENEYKHIVYPPDYENRQINPEGMAFRHKRYYHLFHELNLVLSSAGVQKAICEDVEHLKTLINFLSLFTNMNPNRRAVHLHVEFESDAWVTAFNLTIQLAKLCKFFGECYSKASPEEFVVAVRTLVPSLMDPEQDFHDVQFGSCEAVDDSSIDSGVFYRCIDFRTDRELISFHHPLNWLFAEIMRSAHLIDFEQVHHLGVYGVGDLLIPENATPAEADVAPLALSENVICVASLLAQVRAGLWVRNGFGVRAQQLHYREYSLRETTFDQDIFHLQVLLAAKDPSHVLVAIVDRFAMRQWCNGEFLSDRVYEPSQMIAMLEELLHLLIILLSEPSGISGSSREENLKREIIQVLCLGSMSYSDTIKRIPDRYIQDSSFDKALAMLADFKPPVGSSDVGMYSLKPEFLEEVDPYYCRFGRNQREESERIVVEHLKKTTGVTDPVLVPKCLNINSGPFACISHTYHSEVLLQIIFYSLARVNPTMKGYSEYLADEAIHLVMMGLVEQPDVFAKMAMEKKLPLKGANPHTMTLKMMLEAVDAEPAMKSVQKKVNWCLDRMASIFGLQRTDGKSAESATNAEQIAIQADEQKKEAAKARQNAIMNQFAAAQQAFLLQHDLDDEDDEEEDSDGQTSTSKMALDPEIEKTYGNCIVCQEDLTKARCFGALGLIQRSRMVRLTPVHLEPEQAGLWFEEALLTPESLDVDGRKSSPAGVASRQPVNLSDTKIGPDGSLEPVAWVPRGFPNGAGNRSGLFASVCGHLMHFACFQTYYKSIELRHGTQVTRNHPESIDRCEYLCPLCKSIGNVFLPSVDPSTPLVKPQDSPSSTDLADWISSVGTIEAKMKEETGAGSYNQLFSLNEYGAIKSWLVHLKLDPHPRRSSTATRLGTEERAMLERFLTVTAALNRELPDPSEALGPDTSDGLGQATLTRDLIGYTIACTEIAARGLAQTGGVAGSISETQQQLISSLITVLGWLLEAETGHPSIEEYATGLLIRQLAPANILAHTTRLTGHLPRRPLLFSEPLSLLVYCAIAAPEKLTLLIPLCYQLELLRVMIGLCYLSKKFPYKWWTSERVKINRTKPHRLSEGGALGLLLVKVIDVCGAEGSVLLSADEWELERIVRLYTLPFLRRAWILLNVIGKQPPCDRRGDDEGDEEEDEHVRLKRAMRIPSFLDLRGDEKDDPLTGKKTNTQIYRLMIVGWLGELTEYIRANYGSSRSGLGGVMDGKSLRLIEDFRIRDGFFQLEHPVIYELLGLPIKFDKLLSRAAIKKCPNCNAVPNDPGICLLCGATVCVQAFCCTNRNLDEEPEHGECNVHMWNCGGSVGVYLLIKKCSTLFLAAENGAFSMAPYLDEHGEHDVGMKRGRPQFLHQARWDEIRRVWLTHNVPTFVARRQEASTDVGGWPTF
The following text describes a protein:
Function:
Mediates calcium-dependent cell-cell adhesion during the early stage of development.
Subcellular Localization:
Cell membrane.
Sequence:
MSVESNKVKFFTAKNCTGTGVEYTEGDSVAFEPNDQYNDKFLSCIIGTNVWVNAYQHNDVYNPEPGAHEELKSGTHNDLSSLNGLSKFQVLGNEFGYAIDVKLIASGDLVSSPAGTYKFTIIPYQVSAVTCLNGDDYVQCPIPKLNPPNAEIVCQIIVAQTAWPGATVANGSVYFQYDPSTGILNYRKTEGFPTNMDVTQNGKTNFDFKILKETA
The following text describes a protein:
Function:
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. Does not have phosphomannose isomerase (PMI) activity. Isomerization proceeds through a cis-enediol-based mechanism.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLKFDFSNLFEPNISGGLTDEDVKSVEEKVTSAVRNFVENTPDFAKLDRSWIDSVKSLEDWIINFDTVVVLGIGGSGLGNLALHYSLRPLNWNEMTREERNGYARVFVVDNVDPDLMSSVLDRIDPKTTLFNVISKSGSTAEVMATYSIARGILEAYGLDPREHMLITTDPEKGFLRKLVKEEGFRSLEVPPGVGGRFSVLTPVGLLSAMAEGIDIDELHEGAKDAFEKSMKENILENPAAMIALTHYLYLNKGKSISVMMAYSNRMIYLVDWYRQLWAESLGKRYNLKGEEVFTGQTPVKALGATDQHSQIQLYNEGPNDKVITFLRVENFDREIVIPETGRAELSYLARKKLSELLLAEQTGTEEALRENNRPNMRVTFDGLTPYNVGQFFAYYEAATAFMGYLLEINPFDQPGVELGKKITFALMGREGYTYEIKERSKKVIIE
The following text describes a protein:
Function:
Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MDKDIGSAVAELQVCSTHYAMTIVSCGFHSPQSLMNADLQHCLLADQNYLLNNSNKNKGSIIEENTRKPFQSARNLQTSLKTHPESAITRYGLGYAGFGNGWTALKPKILFPSQKRRVKGRFTFPFSRRSNLAQSKLPVDLVPIRLEIDADRYKLRDSFTWNLYDKCISLDQFAEQICIDYDIPLHNVHIVQNISKSIQAQINDYEPRKAQSNLSFVSDVSSSTSETVYAHEPSDSLAKASKQQIPTVQNDLRILIKLDITIGRLNLIDQFEWNLFAPESSAEEFATVMCLDLGLSGEFCTAVAHSIREQCQMYIKYLSLIGYLFDGSEIEDEEVRSYILPPLKNTLRFSDMESSSFAPMIYELNDAEMERQDRGYDREARRMRRRQGRAKHGIMLPDLRDIPKIHRSLFPSSSVPSDDDFMHALSLSTNSDGETLNEINTNNPEREHLIVRLKVDSQKLKIIVEQSQTLTLNNFQQRKLTPLPNSMSFDSLNEFESERNTPSTYGQNISPLPQFSSPSLSSDAFLTNSNSSESALVHMQKLNLPDFTPSWVKRCVIETFAKFPNDRFNVIVKPALNPAERMTVRICCHDCINEYFTAGPGFTFGNFHIHLLSSSHQQKKEVRMNTVLDRNT
The following text describes a protein:
Function:
Transcription factor involved in endoplasmic reticulum (ER) stress response. Acts as a ER stress sensor and activates the transcription factor BZIP50 and the chaperone BIP1.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus.
Sequence:
MAEPALLDPSSHFDLRHYPAGLFDPDLHLADDDDDLPLGNFGLGAGGVGDCDDLDFDLPADFSVEDFLLRSPERSDSAAGSGPTASSSSPSPAASGTGSAVADASCEVKHEESDEGRSAAAPNWGLKRKPASPAPSSEAAKCRRSGDGEVSPSASASRAAVDSDEGGAVGEGEDTRRAARLIRNRESAQLSRQRKKRYVEELEEKVKSMNSVINDLNSKISFIVAENATLRQQLGSGGGNCPPPGMYPPGAMPGMHFPWVPGYAMRPHGSHVPLVPIPRLKPQQQVTATKATKKPENKKAVDSKSKSKTKTKKVASVSLLGLMLVMLVFGAFVPGFNHNFGLSGGSDNAMFRNFGQPHDRVVNVNNHGQAPKGGLNNSDMTGVDSGMMIGTDGSADQKHQPPLNSSETLPALLYVPRNGKHVKINGNLIIHSVLASEKAVAHGTSQHNRDQSGIDHKETSTAIARHLSLPGNNMNPQEKSPVDGPLPQWFREGMAGPILNSGMCSEVFQFDVSAATNSGGIIPASPAVNSSSVNATRKVPTPAPAYYGKLKNRRIMYNEAIPLTGKTANNTGPFNRTSESSKLPDKKPASSVVVSVLADPREAGDGDSDPRMTPKSISRIFVVVLLDGVRYVTYSCTLPFKSASPHLVN
The following text describes a protein:
Function:
Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity). Formation of iron-sulfur complexes and cyanide detoxification.
Subcellular Localization:
Mitochondrion matrix.
Domain:
Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue (By similarity).
Sequence:
AAQALGRALVSAKWLSEAVRAGRVGAGLRVLDASWYPPEERDARQEFKERHIPGASFFNIEECRDKSSPYDFMLPSEAHFADYVGRLGVSNDTHVVVYDGDELGTFYAPRAWWMFRAFGHREVSVLNGGFKNWVKEGHPVTAEPSQPAEAVFKAKLDKTLLKTFEQAMENVGSKKFQVVDSRPAGRFQGTELDQGLESGHIPGAVNMPFSTFLTESGHEKSIEEIQQMFREKKVDLSKPLTATCRKGVTACHIALAAYLCGKPDVAVYDGSWSEWFHRAPPQYKVTELK
The following text describes a protein:
Function:
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MNKNIKSLNLREKDPFLSREKQRYEHPLPSREWIIELLERKGVPSKIESLARELSITEDEYVFFERRLKAMARDGQVLINRRGAVCAADKLDLVKCRVEAHKDGFGFAVPLTPAKDGDFVLYERQMRGIMHGDIVTVRPAGMDRRGRREGTVLDIVERAQSKVVGRFYMDRGVAILEPEDKRLNQSIVLEPDGVARFKPESGQVIVGEIEVYPEQNRPAVAKIIEVLGDYADSGMEIEIAVRKHHLPHQFSEACAKAAKKIPVHVRKSDLKGRVDLRDLPLVTIDGETARDFDDAVFAEKVGRNYRLVVAIADVSHYVRPDDVIDADAQERSTSVYFPRRVIPMLPENLSNGICSLNPDVERLCMVCDMVVTYAGNIKEYRFYPAVMRSHARLTYNQVWKWISDGIDHPYKAQIDTLYKLFKILQKKRFERGAVEFESVETQMIFDDNGKIEKIVPVVRNDAHKLIEECMLAANVCAADFLLKNKHTALFRNHLGPTPEKLATLREQLGLLGLQLGGGDNPSPKDYAALVEQFKGRPDAELLQVMMLRSMQQAVYEPHCDGHFGLAYEAYAHFTSPIRRYPDLTVHRAIKAVLNQQTYTPKKSWQALGVHTSFCERRADDASRDVENWLKTYYMRDKVGEVFEGKISGMTSFGIFVTLDGIHIDGLVHISDLGEDYFNFRPEIMAIEGERSGIRFNMGDRVAVRVARADLDDGKIDFVLIAGGSGRGRKVKSSASAKPAGTAGKGKPKTAAEKKTARGGKVRGRGASAAAESRKKAKKPVPIKVKKRKGKS
The following text describes a protein:
Function:
Cysteine protease inhibitor. Inhibits cysteine proteases CP1, CP2 and CP5. May protect the cytosol against cysteine proteases released by damaged intracellular vesicles (Probable).
Subcellular Localization:
Cytoplasm.
Domain:
The BC, DE and FG loops form a tripartite wedge that blocks the substrate-binding site of target cysteine proteases. The BC loop interacts with the catalytically active cysteine and histidine residues of the protease catalytic center.
Sequence:
MSLTEDNNNTTITIAKGENKEIILHGNPTTGYSWVVDSCEGLSNTVEYVADQHAPGICGCGGKYHIKITGTQTGEGKIVLVYRRPWAPNANDRTFTLKVNVQ
The following text describes a protein:
Function:
Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MEASSEPPLDAKSDVTNQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQNFYRQFKEIAAVIETV
The following text describes a protein:
Function:
Galactose-binding protein which recognizes specific carbohydrate structures and agglutinates a variety of animal cells by binding to cell-surface glycoproteins and glycolipids. Is a calcium-dependent lectin. Shows high hemagglutinating activity, that is inhibited by lactose, galactose and inositol.
Subcellular Localization:
Secreted.
Sequence:
NNCPQDWLPMNGLCYKIFDEQKAWEDAEMFCRKYKPGCHLASFHRYGESLEIAEYISDYHKGQAEVWIGLWDKKKDFSWEWTDRSCTDYLTWDKNQPDHYEGKEFCVELVSLTGYRLWNDQVCESKNAFLCQCKF
The following text describes a protein:
Function:
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
Subcellular Localization:
Lysosome.
Sequence:
LDHFNFRTSATFSQRYLVNIANWRKGGPIFFYTGNEGDITWFANNTGFMWDNAKEFGAMLVFAEHRYYGETLPFGKRSYESPKYLGYLSSEQALADFATLIRHIKLTTPGATGSPVIAIGGSYGGMLSSWIRMKYPNLVTAALAASAPILYFQGLTPCEGFNEIVTKDFHRDGGDSCVNSIRKSWSVIEKLGATQSGRKTLTSVFNTCSPIKTKYNVTQLQDWLSETWANLAMVNYPYAATFLEPLPAWPIKKVCSHLTDADLPDVALLKAVAGAVGVYYNSSGQAKCFNLSQQAVSSLGDKGWDFQACTEMVMPMCSDGVNDMFKPVKWDFEAFAESCQGSYGVKPRQYWVEVQYGGRDISAHSNIIFSNGLLDPWFAGGVTKSLSPSLVAVLVEEGAHHLDLRHSNPADPPSLIKARQTEKEYLHRWISEYYKN
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MSLDGSESPAATLSPSSSCGDFAALLDAELFVHEESTADRPEDGGLVSAEPDKDGDSSDEEDDSSEESNGEEEESDVDIDADDDDESEAQLVVENDGDNLEESSLKRRRKNETGPSPDSGTEASNHCPPHPGFIWNVCIRCGERKSTEPTNDPVPTHVGLRYIHEGLEVSELEASRVRNAELRRVNKTKKLLLVVDLDHTVLNSARFADVPVGELQAGGSSLHQMTKLGLWTKLRPFAHEFLQEASKLYEMYIYTMGERKYAKKMAKLLDPTRQLFADRIISQNDSTKRYTKDLDVVLGADSAVVILDDTEAVWPSHKSNLILMERYHFFSSSCSQFGVNSASLAQLYRDESETEGTLATTLKTLRAIHHEYFNGKSQKRKLSSDSSDVRLVIRSLRAKLLAGCNVVLGPEIHPFWQLPAELGARCSTFCDHTTTHVVALDPGTDQALWAKEHDVFLVHPRWVDATSYLWSRPPEEDYPVTENPAGPAVVTFAKNVLVEPLIVDDTSDKGEVEPLVDLEPSKDETVSQATNAVELSGSSCLELPPTHVNGLSDASSVEDEDLEIE
The following text describes a protein:
Function:
Transcription factor involved in the regulation of ergosterol biosynthetic genes such as ERG2 and ERG11 through direct binding to sterol response elements (SREs) in the promoters. Also binds to its own promoter on 2 cis-acting elements to promote autoregulation. Regulates sterol uptake across the plasma membrane. Acts as a major regulator of ascorbic acid-induced response. Plays a role in the triggering of pyroptosis, an inflammasome-mediated programmed cell death pathway in macrophages, allowing macrophages escaping.
Miscellaneous:
MISCELLANEOUS: Gain-of-function mutations in UPC2 are more prevalent among clinical isolates than previously thought and make a significant contribution to azole antifungal resistance.
Subcellular Localization:
Nucleus.
Sequence:
MMMTVKQESPNSTLNTSEFSSDENLKTNNSEPPKKVSKSSTGKRKYHQKSRNGCSTCKKRRVKCDEQRPVCGNCTKLKLDCGYLHEPLENILNTKKDIANNEPPSKKRKRKVSTVSAASDSESTTQQATPSLTPSPNHSQDIKTQPVIPPTNPLSALSSGLLSAGNLNNLNVAHLVNNLSGLGDLSNLASLGNLASLSNLASLAQLPIDLSNLGSLLDSPAASNIAASFLGSAAATTVPPTTNSEFKESNQRKSQTQMPPQPTVPITSMGAATTTSSHQQANMPSRSKPQPETLQSSIPATTSGSPGMSYPGCPSNSDPFGRSSDKSLPNISPNMSIPANPLSDPLTQGMRSNLNMLDLKLMFHYTSVVANTITGAGISDTNIWNCDIPKLAFEHPFLMHSILAFSATHLSRTEKGLDQCVTCHRGDALRLLREAVLNINADNTDALVASALILIMDSLANASFPSSTSPKSLPASAWIFHVKGAATILTAVWPLTEASRFYKFISVDLGDLGDIINQGVNMNKSKGIDRENSAYYTDLECHDADIADLFPVLLDSPYLITLAYLNKLHKERYKSDFILRIFAFPALLDKQFMGLLMSGDVKAMRIMRSYYKLLRSFTTEMKDKVWFLEGVSQVLPVNVEEYAGGAGGMHMMMDFLGGGPAIVDDNEIDAEITKFDPSGTLTNKLIDTDNLPSVLTSNLDLMQGDNGFMNMK
The following text describes a protein:
Function:
Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Colocalizes with gamma-tubulin in the centrioles and with glutamylated tubulin in the basal bodies of ciliated cells.
Sequence:
MFPALETHLKQTIPDPYEDFMYRHLQYYGYFKAQRGSLPNSATHQHVRKNNPQYLLHGSLGGKDDLIPDTLQKEKLLWPTSLSSAVHRQIEAINRDSHMLSLPHLRSRQLLYDELDEVNPRLREPQELFSILSTKRPLLAPRWPIECEVIKESIHHIEWAPPQPEYFYQPKGNEKVPEIVGEKKGTVVYQLDSVPTEGSYFTSSRVGGKQGIIKELAVTLQGPEDNTLLFESRFECGNLQKAVRVDTYEYELTLRTDLYTNRHTQWFYFRVQNTRKDATYRFTIVNLLKPKSLYTVGMKPLLYSQMDANTRNIGWRREGNEIKYCKNNMDDGQQPFYCLTWTIQFPYDQDTCFFAHFYPYTYTDLQCYLLSVANNPIQSQFCKLQTLCRSLAGNTVYLLTITNPSQTPQEAAAKKAVVLSARVHPGESNGSWVMKGFLDFILSNSPDAQLLRDIFVFKVLPMLNPDGVIVGNYRCSLAGRDLNRHYKTILKESFPCIWYTRNMIKRLLEEREVLLYCDFHGHSRKNNTFLYGCNNNNRKYWLHERVFPLMLSKNAPDRFSFHSCNFKVQKCKEGTGRVVMWRMGILNSYTMESTFGGSTLGSKRDTHFTIEDLKSLGYHVCDTLLDFCDPDQTKFTQCLAELKELLRQEIHKKFHELGQDVDLEESWSDISLSDIESSTSGSDSSLSDGLPVHLANIADELTQKKMFKKKKKKSLQTRKQRNEQYQKKNLMWKLKLTEDTSEFASTLQKHPAFFKNSESSSFLPMRNENPRLNETNLNRRDKDTSLDPSMTTLILPKNKGRMQTNLNRRDKDTSLDPSMTTLILPKNKGRMQVLHLIYCI
The following text describes a protein:
Function:
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
Sequence:
MMSSAVCRLAPSPTGAQHLGNARTFLIAYWSARAQNARLILRIEDIDSPRIKPWATEQAITDLRWLGMDWDGDPIVQTERSPLYDEARNQLMDADRVYPCSCTRRDIEAAASAPHESEASGWTPDAPVYPGTCASWKNGDPLPEDKPFCFRFRMQATPDRFFDRVHGEVACNPIQDIGDFPITRKAESAADCLAAYQLAVVVDDIDAGVTEVVRGDDLILSTFRQLQLYEALGHSPPSHAHVPLVTGTDGRRLAKRHGDTRLSHFREQGMPPETIVRWAAKSSGLCPDSDAALSERTLDQIHQQMIDRFDWVRIHRQPTVVDDFGSTTD
The following text describes a protein:
Function:
Iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MVAPQRRTVMPALGLLASSLCSLLLTANAATVEQHWNINWVPDVNPDGLYPRHVIGVNGSWPPPIINVNASDTVRITATNKLETGVGASLHSHGMFFNRTGYYDGAVAITQCPIPPGQSFTYETLNSPASPADRRKQMGTFWIHAHNNDQYTDGLRSPVIIHPDDPADIHYNYDDDYTVILGDWYHSNYTDLVKNEFMNRKNPTGAEPVPKSGLIYFAHTSNKTSAATYLPGFSENATLPFEAGKTYRLRVINMSALAAFYFYLSGHDMQVIEVEGVDVLPQPVDFLSVAVAQRFSVLVTARNDTDPQNWKLHANMDEDMFDVVPEDLQLNVSATISYPNAPKDKFGPEKILEEYTYFDDLQFVPVNAEPMVTPDAVHRLDVSFDTMSDGENYAAFNNISYVAPQVPALFSAESMGALASNPAIYGPNSNAFVIKHNEMIEVQLFNWDAGKHPFHLHGHHFQVVHKSQDVTSDDPTINPPFNSSQVNPMRRDTVMVPPGGSAYLRFRADNPGAWFFHCHIDPHLVSGLASIFIEAPDVLSDSFLNVPSYIKNQCQAQGIATTGNAVGLNSTSDFDGLAKGPTYLESGWTGRAIAAFTGCIITGLLGLATVVVYGWHSGEEDDDEEEEDK
The following text describes a protein:
Function:
Hydrolyzes dipeptides containing N-terminal aspartate residues.
Subcellular Localization:
Cytoplasm.
Sequence:
MASARNLLLLSSSRLHGHGYLEHARGQLEDLFKSANVKTVLFVPYALRDHDKYTATVRDALQPWGFNVEGLHTKPDREQALREAQAIFVGGGNTFVLLRSLYEMKLLDPIRELVLQRGLPYVGSSAGTNVATRSIHTTNDMPVAYPPSFEALALVPFNINPHYLDPEAGSRHKGETRDERLEEFVAYHGLPVLGLREGTSVRVQGEKAILLGDRNAKLFKADGGTEELAPLADLTFLLQK
The following text describes a protein:
Function:
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm.
Sequence:
MLALQDDSLFAAIVDNLSDGIYVLQDDRVVYLNERFAQLFGHGDAGSLLMRELDDILPHGEGKEIVGRIHAELLAGEPSSVAWGQPFAHMDGTPVWLEMEARRIRLNGRPAILGVCHDRTDCKLIGEAMHISQETFRLVLDAMHDSVYVVGRDYNVIYANRAMRAGAYGDVSSDPCYRICRGCSEPCPDCTLEEVLSSDKPVCREFFDEKRNAWYSTIELAVRIPGMSAPAKLGVRRDITARKEAEQRSRMLSQRLLHAQESERKRLSRELHDDLGQLLNALKIGFDTLAEDLRQPSHDVQDRLWYLSESLNNSIHTIRRLCAGLHPSTLERLGLAETIRQQCTQAATTHSLDIELKCGTMLGVRLESDTEINLYRIFQEALHNVVKHADATRVMVRLVASHPTVRLQIEDNGGGFSMEDYAELSGHHLGLISMAERVELLGGTFQIASLPGLGTAVTVEVPFRKAPPGRTTAAKGRPSLPYPVRGRKSLYVC
The following text describes a protein:
Function:
Involved in the control of the switch from cell motility to adhesion via regulation of cellular levels of cyclic-di-GMP (c-di-GMP). Part of a signaling cascade that regulates curli biosynthesis. The cascade is composed of two c-di-GMP control modules, in which c-di-GMP controlled by the DgcE/PdeH pair (module I) regulates the activity of the DgcM/PdeR pair (module II), which in turn regulates activity of the transcription factor MlrA and expression of the master biofilm regulator csgD. Effect on flagella is controlled via the c-di-GMP-binding flagellar brake protein YcgR.
Sequence:
MIRQVIQRISNPEASIESLQERRFWLQCERAYTWQPIYQTCGRLMAVELLTVVTHPLNPSQRLPPDRYFTEITVSHRMEVVKEQIDLLAQKADFFIEHGLLASVNIDGPTLIALRQQPKILRQIERLPWLRFELVEHIRLPKDSTFASMCEFGPLWLDDFGTGMANFSALSEVRYDYIKIARELFVMLRQSPEGRTLFSQLLHLMNRYCRGVIVEGVETPEEWRDVQNSPAFAAQGWFLSRPAPIETLNTAVLAL
The following text describes a protein:
Function:
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections. The first step of the pathway is the formation of the heptaketide backbone by gsfA which is initiated by priming with acetyl-CoA, followed by sequential condensations of 6 malonyl-CoA units. The resulting benzophenone can undergo a spontaneous dehydration to form norlichexanthone. However, the true precursor for the griseofulvin biosynthesis is not norlichexanthone, but the heptaketide benzophenone that is O-methylated at 3-OH by gsfB to produce griseophenone D which is further methylated at 9-OH by gsfC to yield griseophenone C. Griseophenone C is then substrate of halogenase gsfI which is responsible for the regio-specific chlorination at the C13 position to form griseophenone B. The cytochrome P450 gsfF catalyzes the coupling of orcinol and phloroglucinol rings in griseophenone B to form desmethyl-dehydrogriseofulvin A which is further methylated at 5-OH by gsfD to yield dehydrogriseofulvin. Finally, gsfE performs stereospecific reduction of enone 18 of dehydrogriseofulvin to afford the final product griseofulvin.
Sequence:
MSTPEQWIQEFEALCSRASILFPSGIEDENIRIRALRIAEKAVHQLHTPMTFAEAQTWAPLELFGAGVACEMGIFDVLSKSSVPLSPVDIATELNTDPALVARIMRLLDAHYMVDQVTLGQYAANAITRDYVQPYRKGNVMTQVALMPSYFALPAWLRDNDYKVRPDANHCAWQVGANTTKTFWEMPRTTQEDDFVTFYPFEAVFSTSNVDDILFVDIGGGLGHQAMRVRSAFPRSRGRIIVQDLPQVTNKITTASLPDVEIMDHDMADPQPVKGARVYYLRGVLHNHADHISIKYLSQFAAAMSPESRLLIHEALATDLNPTKNITRFDLSMLASCGGAQRSEAEQKALLEKVGLEVSGVWSTPRDWSIMEARLKRE
The following text describes a protein:
Function:
Bifunctional chorismate synthase and flavin reductase. Catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate. Acts also as a flavin reductase (FR) able to generate reduced flavin mononucleotide in the presence of NADPH.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSTYGTLLKVTSYGESHGKAIGCVIDGFLSNIEINFDLIQKQLDRRRPNQSKLTSNRNEKDKLVILSGFDENKTLGTPITFLIYNEDIKKEDYNSFINIPRPGHGDYTYFMKYHVKNKSGSSRFSGRETATRVAAGACIEQWLYKSYNCSIVSYVHSVGNIKIPEQVSKELENKNPPSRDLVDSYGTVRYNEKEKIFMDCFNRIYDMNASMLKTDEYNKNTLTIPSIDNTYINVKTNECNINQVDNNHNNYINDKDNTFNNSEKSDEWIYLQTRCPHPYTAVQICSYILKLKNKGDSVGGIATCIIQNPPIGIGEPIFDKLEAELAKMILSIPAVKGIEFGSGFNGTYMFGSMHNDIFIPVENMSTKKESDLLYDDKGECKNMSYHSTIQNNEDQILNSTKGFMPPKNDKNFNNIDDYNVTFNNNEEKLLITKTNNCGGILAGISTGNNIVFRSAIKPVSSIQIEKETSDFYGNMCNLKVQGRHDSCILPRLPPIIEASSSMVIGDLILRQISKYGDKKLPTLFRNM
The following text describes a protein:
Function:
Could be an iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein; Extracellular side.
Sequence:
MNKFFSFPILGLLLTCVRFVVAKERLFEWNVTDVYDVDPDGSGNSRWVIGVNNKWPIDPLVVDYGDQVIIKMTNSLANNRTTSLHSHGLFQKFTPYMDGVPQSTQCEIPPGATFYYNYTALQNGTYWVHSHDMSQYPDGLRTPFIINALEEPYDYDEEYIISMTDWYYTPFNILVPDEFKTWKNPTGAEPVPDTGLFNDTANATFAMEPGKTYRLRFINIGAFNNYDVMIEDHNMTIIEVDGEYTEPQEVSSIHLTVAQRYSVLVTAKNSTDRNYAITAYMDESLFDTIPDNYNPNVTAWLSYNSDASYDLGPDIDEIDSYDDAELNPLYSWDVTESNHSINIWFDFFTLGDGANYAEINDSSYVFPKVPSIMIANSTNVDGYNLEPVTYGPYTNAYIFEYGDVVDVIIDNHDTGKHPFHLHGHTFQVLERGEENAGLYSDQESHTYYDNPMRRDTVEIEPGSFIVIRFIADNPGAWVIHCHIEWHMESGLLATFIEAPEMIPSISSPDFVKEQCMLDGVPTIGNGAGNYKNISDLSGAPSPPGEMPAGWTSKAIGTMAACVISACIGMGSIIFYGASIHPVPTEELDENDDLQEAALENAAMFLDTDKAVEKVVEGKDEIK
The following text describes a protein:
Function:
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Subcellular Localization:
Secreted.
Sequence:
MHALRSSVLALWLCLHVSVRAWMTYRSANGLDEYEPEDRIIFVGTKWCGNGNVAEGPEDLGSLKETDACCREHDMCPDLIEAGQSKHGLTNTASYTRLNCACDEKFYNCLKNSSETGSGAVRFTYFTLLGTMCYRNEHPLICVKKGWFSCSKYELDQSQPKRYQWFDVSSNFAFPRMLT
The following text describes a protein:
Function:
Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel-mediated induction of antimicrobial peptides. Anti-apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses rpr and hid-dependent cell death in the eye. However, has also been shown to have little, if any, role in the regulation of the canonical caspase-dependent apoptosis pathway. Plays a role in regulating the expression of ion channels.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MTELGMELESVRLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAERHRRSSPICSMVLAPNHCGNVPRSQESDNEGNSVVDSPESCSCPDLLLEANRLVTFKDWPNPNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKRFFPQCPRVQMGPLIEFATGKNLDELGIQPTTLPLRPKYACVDARLRTFTDWPISNIQPASALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPAYVSEVLATTAANASSQPATAPAPTLQADVLMDEAPAKEALALGIDGGVVRNAIQRKLLSSGCAFSTLDELLHDIFDDAGAGAALEVREPPEPSAPFIEPCQATTSKAASVPIPVADSIPAKPQAAEAVANISKITDEIQKMSVATPNGNLSLEEENRQLKDARLCKVCLDEEVGVVFLPCGHLATCNQCAPSVANCPMCRADIKGFVRTFLS
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
Sequence:
MTVSEAYSPPLFSIAPMMGWTDNHYRTLARLITKHAWLYTEMLAAETIVYQEDNLDSFLAFSPDQHPIVLQIGGRNLENLAKATRLANAYAYDEINFNCGCPSPKVSGRGCFGALLMLDPKFVGEAMSVIAANTNAAVTVKCRIGVDDHDSYNELCDFIHIVSSLSPTKHFIIHSRKALLSGLSPSDNRRIPPLKYEFFFALLRDFPDLKFTINGGINSVVEADAALRSGAHGVMLGRAVYYNPWHILGHVDTVVYGSPSSGITRRQVLEKYKLYGESVLGKYGKGRPNLRDIVRPLINLFHSESGNGQWKRRTDAALLHCTTLQSFLDEVLPAIPDYVLDSSAVKEATGREDLFADVQRLLPPPYEKESFKALERIPTRPVILDEE