lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle. Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently.
Subcellular Localization:
Cytoplasm. Membrane; Single-pass membrane protein.
Sequence:
MPGEMRGGCEAGGGERCGIVLGETMEGEKRPAPSEGLFADGHLVLWTLCSVLLPVFITFWCSLQRSRRQLHRRDIFRKSKHGWRDTDLFSQPTYCCVCAQHILQGAFCDCCGLCVDEGCLKNADRRFQCKEIMLKNEGRALDAMPHHWIRGNVPLCSYCVVCKQQCGTQPKLCDYRCIWCQKTVHDECMKNSLRNEECDFGEFKNLIIPPSYLTSINQMRKDKKTDYALLASKLGKQWAPLIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPCYSARVLVCGGDGTVGWVLDAIDEMKIKGQEEYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYHLRKPKEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVELPNLEGIIVLNIGYWGGGCRLWEGMGDETYPLARHDDGLLEVVGVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHALMLYFSGEQTDDDISSASDQEDVREAE
The following text describes a protein:
Function:
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MISARQLAFLILRDINRRDSYTDVAIDRALQKHPLSPPDRRFCTELVYGVVRRQRTLDCLIEQLGDRPIGKQPPDLRRIVQLGLYQLRYLDQVPASAAVNTGVDLAKANGLKGLSKVVNGMLRRYQRAEEQGKNILDQEKISLGEQYSFPDWLMELFEQTWGKAETESLCAYFNQNPSLDLRINPLKTSRVEVAQSLAELNLTTTAMAGLPQGLRLGGKTGAITQLPGFAEGWWTVQDASAQWVAQILNPQPEETIFDVCAAPGGKTTHIAELMGDQGQIYAGDRHGWRLQKLAVTQQRLGLTSIKIWEGDLTQPGVKPPVELVDRALLDVPCSGLGTLHRNPDLRWRQTPATIATLLPLQQALLKAIAPLVKSGGTLVYSTCTLNPAENEAQIERFLQDHEDWRSEPFEWTSPQGQTNSVTSGMLTILPHHHHQDGFFIANLKKA
The following text describes a protein:
Function:
May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MEKVEEDLNLSFLLDHEREMILKVLQKDEKLRKQEEKRIRKMKNELLEIKHKGFPRPQESGDRLCARCLKTLGLIFDRGELCEECQQRVCSECRALTANSRKWRCNVCAKVLELKVVSGEWFLEERSKRFEQQVMSSDVIKHTILTSPPSAEKKPAEKPPVSPNPEKHGKSKPGRSAIRNIVDGAKKKGRMKADKKGGRSNLKPEDRVDGASAKSASDGESHSSGSVGSAQSTYSNRSAAVAVESSGLTTVPNNLRSQTPAKSSTPGETRRVRPDGAESVSSLQSGDSLPEKKASGHHRKSSGTPAISVSRVSLSSDRSHSEMDLSAFGSEPSDDALTQAGFSDEDVEEDIDALVPSYSPSPKLYLSSAVSTSSTPASERRWGYLSVPDSDAETSSINSMTSMYSETGDYGNARVSGEILMNISYSYKTGALNVLVKECHNLATGDERKQRTDAYVKTYLLPDKSRQSKRKTSIKANTINPVFNESLRYVISHSQLELRTLQVSVWHHDRFGYNSFLGEVELSFDSWEFDSQIEEWYALQPRVDGSTDSTMHYKGELTVVLKYIPAEINTTPPPDQVQVKKGFLKGKKTSSFTLPKGGMVELLVKGAKNLTAVKAGGYSDPFVKGYLLPDSNKSTKHKTAVERRTVNPHWNHTFTYCGLQPGDLNNICLELTVWDKEALASNVFLGGVRLGAGTGNSYGNEVDWMDSYGEEQRVWQRMIETPGVPHECTLLLRSSMRKRNT
The following text describes a protein:
Function:
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (By similarity). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (By similarity). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (By similarity). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (By similarity). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (By similarity). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (By similarity). Selectively promotes FGF-induced MAPK activation through SRC (By similarity). May play a role in the polarity, proliferation and migration of endothelial cells.
Subcellular Localization:
Recycling endosome. Cytoplasm. Cell projection, podosome. Cell junction.
Sequence:
MRTLEDSSGTVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAGAGGTGSPQASLEIGAPEDSQVLQQATRQEPQGQEHQGGETHLAENRLYRLCPQPSKGEELPTYEEAKAHSQYYAAQQAGSRLHGGDRDPRGASGGSRRQDEALRELRHGHVRSLSERLLQLSLERNGARVPSHMSSSHSFPQLARSQQGPQPRGPPAEGPEPRGPPPQYPHAVMAQETAAVNDPRYRPRSSPHFQHAEVRILQAQVPPVFLQQQQYQYLQQPQEHSPPLHPAALGHGPPSSFSPPALEGPPGAQATSGSAHLAQMESVLRENARLQRDNERLQRELESTSEKASCIEKLENEIQRLSEAHESLMRTSSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRHLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQSRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQTGTLTGGGGSHTGSTELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLAGNHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRKDPGKATQGTLRPAKSVPSIFAAAVGTQGWQGFSTSERQTDAPARQTVDRGPAEEPPATPPLPAHTKHGSRDGSTQTDGPADSTSACLASEPDSLLGCNGSQRTTSLDSIAATRVQDLSDMVEILI
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MDFESNGAMMEYCKSTGRTYCAFSIQQSSKLLGTVVLELFTDIAPATCANFIKYIKDGYQGTPLHRIVPNGWVQGGDIVDGSGKGDPGFVLPDETYSVKHDAPGVLGMATGGQPHTANTQFYISLSPLPFLDGKRVAFGRVLNKQSLENLLALQTLPTFQNERPVPDVVIASCHVIYNPNS
The following text describes a protein:
Function:
Calcium-binding protein. Binds one calcium ion per monomer. Can promote differentiation of adipocytes (in vitro). Overexpression in 3T3-L1 preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake.
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm. Note=Primarily nucleolar. A high intracellular calcium level induces nucleolar exit and nucleocytoplasmic transport, whereas a low intracellular calcium level leads to nuclear translocation and accumulation within specific region of nucleoli.
Domain:
S100A16 proteins, but not other S100 proteins, have only one functional Ca(2+) binding site per monomer. Upon Ca(2+) binding, undergoes conformational changes leading to the exposure of hydrophobic patches which could be implicated in the Ca(2+)-dependent nuclear export. Binds Zn(2+). Ca(2+) and Zn(2+) do not bind to the same site. Does not bind Cu(2+).
Sequence:
MADCYTELEKAVVVLVENFYKYVSKHSLVKNKISKSSFRKMLQRELNHMLTDTGNRKAADKLIQNLDANHDGRICFDEYWTMIGGITSPMANLIRQQECQQESQQECQQESQQESQQESQQGSS
The following text describes a protein:
Function:
Responsible for the proteolytic maturation of the alpha-factor precursor.
Subcellular Localization:
Vacuole membrane; Single-pass type II membrane protein. Note=Lysosome-like vacuoles.
Sequence:
MSASTHSHKRKNSHLFPQRKSSNSSMDKPFFPNNDSVANTDPQSNENGHTINEIRPTEATIDVTDVPQTPFLQEQYSMRPRRESFQFNDIENQHHTHSFFSVNKFNRRWGEWSLPEKRSYVLVFTLIALSVLVLLVILIPSKLLPTKITRPKTSAGDSSLGKRSFSIENVLNGDFAIPEDTFHFIDPPQRLLGQDSDPGLYFTTKEIDGHTNFIAKQLFDETFEVNLGGNRFLYEGVEFTVSTVQINYKLDKLIFGTNLESEFRHSSKGFYWIKDLNTGNIEPILPPEKSDDNYELGLSKLSYAHFSPAYNYIYFVYENNLFLQQVNSGVAKKVTEDGSKDIFNAKPDWIYEEEVLASDQAIWWAPDDSKAVFARFNDTSVDDIRLNRYTNMNEAYLSDTKIKYPKPGFQNPQFDLFLVNLQNGIIYSINTGGQKDSILYNGKWISPDTFRFEITDRNSKILDVKVYDIPSSQMLTVRNTNSNLFNGWIEKTKDILSIPPKPELKRMDYGYIDIHADSRGFSHLFYYPTVFAKEPIQLTKGNWEVTGNGIVGYEYETDTIFFTANEIGVMSQHLYSISLTDSTTQNTFQSLQNPSDKYDFYDFELSSSARYAISKKLGPDTPIKVAGPLTRVLNVAEIHDDSILQLTKDEKFKEKIKNYDLPITSYKTMVLDDGVEINYIEIKPANLNPKKKYPILVNIYGGPGSQTFTTKSSLAFEQAVVSGLDVIVLQIEPRGTGGKGWSFRSWAREKLGYWEPRDITEVTKKFIQRNSQHIDESKIAIWGWSYGGFTSLKTVELDNGDTFKYAMAVAPVTNWTLYDSVYTERYMNQPSENHEGYFEVSTIQNFKSFESLKRLFIVHGTFDDNVHIQNTFRLVDQLNLLGLTNYDMHIFPDSDHSIRYHNAQRIVFQKLYYWLRDAFAERFDNTEVLHL
The following text describes a protein:
Function:
Catalyzes the reversible phosphorylation of UMP to UDP.
Subcellular Localization:
Cytoplasm.
Sequence:
MMKKRVKRVLFKISGEALSDGDSSNRISEERLSRLIAELKVVRNADVEVALVIGGGNILRGLSQSQSLQINRVSADQMGMLATLINGMALADALKTEDVPNLLTSTLSCPQLAELYNPQKASDALSQGKVVICTMGAGAPYLTTDTGAALRACELKVDVLLKATMHVDGVYDQDPRECADAVRYDHISYRDFLSQGLGAIDPAAISLCMEAGIPIKMFSFARHSLEEAVFNTVGTVISSTEGGQL
The following text describes a protein:
Function:
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination. Within the MRN complex, nbn acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites. Recruits mre11 and rad50 components of the MRN complex to DSBs in response to DNA damage. Promotes the recruitment of PI3/PI4-kinase family members atm, atr, and probably DNA-PKcs to the DNA damage sites, activating their functions. Mediates the recruitment of phosphorylated rbbp8/CtIP to DSBs, leading to cooperation between the MRN complex and rbbp8/CtIP to initiate end resection.
Subcellular Localization:
Chromosome, telomere. Nucleus, PML body.
Sequence:
MWTLLSAAGSARGDSYRLLVDVDYVVGRKNCGILLEDDQSISRNHALLIVRHSVTNLSQASEIPMLTIKDNSKYANLNVSGKTVLNQAVLQLGGLIVNNWTEECTHLVMVSVKVTIKTICALICGRPIVKPDYFTEFLKAIRTKKRPPKLESFYPPIDEPAINNENLDLSSRKERKQIFSGKTFIFLNAKQHKKLSPAILLGGGEAKLATEEDKEAATSFLTPGTCVVDAGLTNSQALVPDSVRIWIRSIMDMLQSHHLRAIPEAEIGLAVIFMSTETYCNPGTGLALSPRPPSLSQNKMVNETLMPGATMNITAGIPDTESEQENTCLDLSESPKENETPQVEQRSKVFSQEMFTVKEIPNTNCSVNLGTKPLNQTSIKTPNSQLSPSKISRKRKEQASQEQQTNSIKNYFQSVSKKRERNEEEQEESVSKSSRVELSCSLLDQTQPTTSSAWRNQEQHQTQKGLNMLNKKTDETYRNTNLKLNENSPVDELFKSNSRKRKELDDVAMENEHLHQEQEQEVEIGVQRPVNGISLGKKLRLDIRKNDSEDNEPTQESCKIVQENDQERNNDKLQDSCERLPKNLLLTEFRSLVVSHSGSRNASIIRNDYGQLNNFKKFKKVAYPGAGKLPSIIGGSDLIAHHARKNAELEEWLRQEIEVQNKHAKEESLADDLFRYNPNVRKRR
The following text describes a protein:
Function:
Acts on leucine, isoleucine and valine.
Sequence:
MLKSFSMDFAFFEGKIVPVEEAKISIMTNSFHYGTAIFEGIRAYWNEEEEQLYILFAKEHYERLLTNARCLFMELNYSAEELVEITKEILRKSEIREDVYIRPIAYFKDLKLTPKLIDYTPEIAIYLYRFGRYLDTSKGIRAKVSSWRRNDDNSIPSRWKVAGAYVNSALAKTEALMSGYDEAILLNSQGYVAEGSGENIFIIKNGKAITPSPNEHILEGITRNAVITLLKKELVVEVEERPIARSELYTADEVFLTGTAAEVTPVVEIDNRKIGNGEIGPITKQLQEFYFNAVRGKIQRYKKWLTPVYDK
The following text describes a protein:
Function:
Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex.
Sequence:
MPAKTPELEMMDEDRLIEEVLDKFVNCHEQTYEEFLRTFTHLSKDNVTKREAFGTNSSENNFTSIKFTQRNEPNDCRLSNKAIFLHTSSQCSEEEQIMIGDGQKAGSSFQGDLNRAGKVKVDNFLDIEDLDLDEEINPQLSKDVLLLPGQVEQEVSLSVPSYIPSVAIQPVTPGTKPRPTVKAADKQSKEIVGDEVQPFSLDEEFDYDAVVLTPKFTPAEMNAIKELSKQKTKSADLEDPHD
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MDFRQLRTFSCVAELGSLSKASDTLRVAQPALSRQIKLLEHELRIELFTRNGRGMVLTEAGRLLLARTSGIVRQIDQIRDDIQSAKGPPSGQVVLGLVPTVSCVLSARFARRCVEKFPGISLRIVESYSGHLVEWLHRGEMDLAILYGRSADLHLNVQSLGRDNIVAVGPRGCGLARKKSVEIGWLLRQRLVLPSHSHGLRALIEHAAAQRKIKLNVQLEADSFRVLTSLVEEGLGFALLPPSSVHGEVADGRLETAVVSRPMTRELIFASPIDRPASTASLAITALLREEVAACRKEGVWDIKLS
The following text describes a protein:
Function:
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
Sequence:
MATSLRRPSFTACSSSLLDADDEGVRGPCEDASLCKRYLRGAGRFAVSIGYWQDPCIPHLVRLSKARKAPEINRGYFAHVHSVSQLIKAFLRKTGCNCQILNLGAGMDTTFWRLKDILLMSTASVSFIKVFLRKTGCNCQILNLGAGMDTTFWRLKDEDLLPSTSWKVDVAGITTRKLHTRAPWHQNQLLADSRADCGRPHVGTAFLSWPLPSLPVP
The following text describes a protein:
Function:
May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.
Subcellular Localization:
Secreted.
Sequence:
MKTLPLFVCICALSACFSFSEGRERDHELRHRRHHHQSPKSHFELPHYPGLLAHQKPFIRKSYKCLHKRCRPKLPPSPNNPPKFPNPHQPPKHPDKNSSVVNPTLVATTQIPSVTFPSASTKITTLPNVTFLPQNATTISSRENVNTSSSVATLAPVNSPAPQDTTAAPPTPSATTPAPPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTLDPSSASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETSAAPTHQTTTSVTTQTTTTKQPTSAPGQNKISRFLLYMKNLLNRIIDDMVEQ
The following text describes a protein:
Function:
Substrate adapter of E3 ligase complexes mediating ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, and which is involved in various processes, such as ribosome recycling and reticulophagy (also called ER-phagy).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MNESEIPIDIHTLKLQDWLISRRIVPKNVQQELREIHRKISNALQDMPSNEQLIKLLARTNINYYHVKEIIEILKQTEKDTKSVFGTYGSQRMKDWQEISRLYEKNATYLAETAQIFVRNVNYEIPGVRKQMARLEQQADETQKRAHDLNKPESQILADHSALLEQLGVKGDNLHAEFVQVLSGLPELYDKSLVGIANIQPGIDLYAEVSGNKQVLPILNHLVEFGNTTVYQYIHKEAPLAVEEPPIRLNLSEGNASKDDNAVAEIDFGTDDNGGTSSTVSAEIIDYGDFGSGDLPESDGGNIDWGIESAPTDAVEINFDIPVEEYGIVVEGTGMDGGTAKGDQAYTLLDSPNYRDRFLDEIYELESFLRMRIYELKQLESSSDIMFSLMDNIATHDGESIWKILVSVEKIIQQTSDKQTQHLFQLKHSPKYANMLATKLQQMTKAVEKLRATREALKQLTIELREQRQDLNPVLEELIAQTRTLQSHIEKDISKRYKNRVVNLMGGVN
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
VSQAETVPVSGESRAAEDPLCGKFTWPIENFSKITIKKYYSDPFVIGGYKWRILVFTQGNNVDCLSMYLDVADSASLSYGWSRFAQFNLAVINQFDPKLSIRKDTQHHFNAKESDWGFTSFMPLHDLYDPGRGYLVNDTLILEADVNVRKMVDSFSYDSKKETGFVGLKNQGATCYMNSLLQTLYHLPFFRKAVYHMPTTEHDVPSSSIPLALQSLFYKIQYSDTSVATKDLTRSFGWDTYDSFMQHDVQELNRVLCEKLEDKMKSTAVEGTIQQLFEGHHMNYIECINVDYKSTRKESFYDLQLDVKGCKDVYASFDKYVEVEKLEGDNKYHAEQHGLQDARKGVLFVDFPPVLQLQLKRFEYDFVRDTMVKINDRYEFPLQLDLDRENGKYLSPDADRGVRNLYSLHSVLVHSGGVHGGHYYAFIRPTLSDQWYKFDDERVTKEETKRVLEEQYGGEEELPQANPGFNNTAFKFTKYSNAYMLVYVRECDKDRIICNVDEIDIAEHLRVRLKREYDDKEKKRKEKSEAHLYTVIKVVTREDDISEQIGRDIFFDLVDHDRIHSFRVLKQLPFAKFKEEVSKEFNVPVNCQRFWLWAKRQNHTYRPSRPLNEQEESQMVGNIKETATNKTYNGELRLFLEVQKAQDMYIPLSPSEKTKDDILLFLKLYIPDKEDLRYAGKLMVKANGKAADIVEKLNEIAGYPSGEEILLFEEIKFDPNVMCEPIDKKLTFRDSQLEDGDIICFQKAVSKEDSQQLSLPNVAMFLEHVRSRQVHSLVAPFLHSLR
The following text describes a protein:
Function:
May participate in maintenance of mesenchymal cell lineages derived from both mesoderm and the neural crest and in patterning of the limbs and the face.
Subcellular Localization:
Nucleus.
Sequence:
MASSYAHAMERQALLPARLDGPAGLDNLQAKKNFSVSHLLDLEEAGDMVAAQGDEGGGEPGRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLASKNASLLKSYSGDVTAVEQPIVPRPAPRPTDYLSWGTASPYSAMATYSTTCTNASPAQGMNMANSIANLRLKAKEYSLQRNQVPTVN
The following text describes a protein:
Function:
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Subcellular Localization:
Nucleus.
Sequence:
MGKRKERREQKKVCSEGGDESKEVEENRFFACYLLTSMCPRFKGHTYIGFTVNPRRRIRQHNGEVRMGALRTKRKRPWEMILCIYGFPTNVSALQFEWAWQHPVESRAVRQAAASFKTLGGVANKIKLAYAMLTLPEWQSLNLTVNFFSTKYKMHSAGCPSLPEHMRVHICALDELPCYTGIDRDEYSTNEWENSEELTDEISASSTNSNSSFSNQDKDSTDENDDEHTDWKELDERAGENSTCGREHSYIIIDSPVERSSSILGDFFHIADKKERHELDDEFGEKQANKMCSTKTDDSLATKNAGLPSDIEVIDVFTPPCSKVRADHKRRRFSASCPEIIDLTDSPIYV
The following text describes a protein:
Function:
Putative methylesterase.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MGNKIISMMKKDSKDGGGGGSKSKRMNRSQRKLLADEEMLHRRALSMAIHQAQLSQRFDGSMSRRVGSTSTRKRTLSDPFSNGKQVPDFSESLIVKKFVLVHGEGFGAWCWYKMVASLEESGLSPVTVDLTGCGFNMTDTNTVSTLEEYSKPLIDLLENLPEEEKVILVGHSTGGASISYALERFPEKISKAIFVCATMVSDGQRPFDVFSEELGSAERFMKESQFLIYGNGKDKPPTGFMFEKPHMKGLYFNQSPNKDIALAMISMRPVPLGPMMEKVSLTAERYGKGRRFYVQTLDDRALSPDVQEKLVRENSPEGVFKIKGSDHCPFFSKPQSLHKILLEIAQIP
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
ELELGRKWDRCLADVVVKIGTAFRSGMGLGMAYSNCHAPYLLHGKYVKEQEQ
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
Sequence:
MVRVSVLNDALKSMYNAEKIGKRQVMIRPSSKVIIKFLTVMQRHGYIGEFEYVDDHRSGKIVVELNGRLNKCGVISPRFDIGVKDIEGWTARLLPSRQFGYIVLTTSAGIMDHEEARRKSVGGKVLGFFY
The following text describes a protein:
Function:
Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. In vivo, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the 4-O-position of carminomycin to form daunorubicin. In vitro, it also methylates the anthracyclines rhodomycin D (10-carbomethoxy-13-deoxycarminomycin), 10-carboxy-13-deoxycarminomycin, 13-deoxy-carminomycin and 13-dihydrocarminomycin at the 4-hydroxyl position.
Sequence:
MTAEPTVAARPQQIDALRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALAARTDTRPEALLRLIRHLVAIGLLEEDAPGEFAPTEVGKLLADDHPAAQRAWHDLTQAVARADISFTRLPEAIRSGRPTYESVYGKPFYEDLAGRPDLRASFDSLLACDQDVAFDAPAAAHDWTNVRHVLDVGGGKGGFAAAIARRAPHVSATVLEMAGTVDTARSYLRDAGLSDRVDVVEGDFFEPLPRRADAIILSFVLLNWPDHDAVRILTRCAEALEPGGRILIHERDDLHENSFNEQFTELDLRMLVFLGGALRTREKWDGLAASAGLVVEEVRQLPSPTIPYDLSLLVLAPASTGA
The following text describes a protein:
Function:
Involved in cuticular wax formation. Required for the synthesis of alkanes from wax precursors. May play a role in acyl-CoA reduction to aldehydes. Is repressed by FREE1 and functions downstream of FREE1 to negatively regulate multivesicular body (MVB) biogenesis and vacuolar transport. Together with CER16/RIPR, acts as a cofactor of the cytoplasmic exosome and connects the cytosolic RNA exosome to the SKI complex. Acts as a post-transcriptional gene silencing (PTGS) suppressor. RST1 can, like CER16/RIPR, suppress the production of small interfering RNAs (siRNAs) from the CER3 locus, which is involved in cuticule membrane and wax production, and in the typhine and sporopollenin biosynthesis of pollen.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm, cytosol.
Sequence:
MASYATLLEKTRVPQPSIQRFAVISVFSKLRSAPEQFGSEAEAGREAISFCLTSESITVVDQSVHELCRLVSDSVLDLSRGLLELQSALEGCDSKLVSLFVKGLGFLIRIGYERNNGNWKFNSTENHPFVRIQSSRVETQTELLHQVSLFVMHNRRLGMVGVCEFLEPFLNFTILRIPLSDSSSSLFARELISSMASLCCSSRHEALPIFRLLMRCLKYIPGNNLEVIVKILVDAYTVVVRDLVGTGLEVTEVHLLGVQLVDGVLFLCASPHVQTTEQESVIESLKHLLAVQKDLGLAYSHDLSLVVLSLVFMLAKSTVEHEQLCILKFLLFLLKWKTESENLSVKDAAGSSVESLLLFPITALMSSPSKSIKVAASKVLSIVENFLVTVSNAPKIEVHTSKGDSPLSRVGSVVFRFMQQLWHQNDYTPSTSSFLRVAYTNGSEKQETYLGPVTWNSLLREHAERFWDKKKLSASFCLSQEIPILLGAVAGVMVMHPSLGADAIGSLTIIGGIDSKMSVPLLLAVLYFSNLLSRTNVPCQSLLSKLLGLLPSLAAQQVMIPLVVQTITPMLRKDAKGLLYATAIRLLCQTWVVNDRAFSSLQEVLRPQGFIEYISERHICISMAASIHDVCKRHPDRGVDLILSVQACIESQNCPVRALGFQSLSHLCEADVIDFYTAWDVIKKHAQHIKLDPLLAYSVCHLLKWGAMDAEAYPEDAENVLNILWEIGSSMQKPHDSQWTKARVSAIVALGQYEVSFMENKFSDFNKNCTYLLFSETNAEILNALEDLSIKIMIHEHSVRRRYVREKKVPGSKIEKLLDVIPQVIFPAGKEIKTGELPGAALLCLSYNPRDVKFGSSRSFHDVHFQYEEAFRVVVKSLQLSRNISLALISLQSLKAFMRRWMRANILSIDATTKELSSDKTSKATNNIMKSLVHMAEEALPRCAENIALALGALCAALPAASHNIKASASKFLLSWLLEHEHEHRQWTAGISLGLISSSLHVTDHKQKFQNISGLLEVLCSSKSTLVKGACGVGLGFSCQDLLTRTEASASSDIDSDSYRNQEERLLGRIVRLLSSILHGFLHTPCDILESLSALFPPGEEDNVIGLPQLLDESSDDFDDDTWGIAGLIIGLGMSVGAIYRAGKKDAVVKIKNLIVSWIPYADSLKQTSGSNSKVSVRLFSVGSCLALPIVITFCQKVELFDAHEVDDIIGCFKDLISELLIVRKSGALRKRLLMASCIGAGDLLGSVLNEGIHPVKIESVKELLELFKKCYSGLYPPVAHFGGMLGVVNVLGAGAGNLVYSHPRPRAPPASSEENEISYVSGPLLSNAYFTQQLTPVVQEIFLIAQNTKDRQLQHYAAWAISILRTYMRSGESSSLSNENQSDDSDRNSISHNVPEHTMVMKLAQGLTNPSFPLAGSPLNIGTMASALRCLSHAPRLPNLDWGATIRRLMKQETQTDVTQSGDVPKEITLREECFKFSLAHASEFDELLAFLDELSELSRFKALEESLQSCLLCHLGGLMRIFSGSRMNKLFDDVSCFVVSLSSDQTYSCDQKSSLRVSCWKGLSQCLEETSLESSEYVTKIEKCIELLFAVLPVASQSPRADQMGSVKEWSEAVTCLQKSHRDWLYKFLQVSNLEPGNEKTNFQGDLKKIQAKAKLAKLGSVPFSELGKLKAIILNCEESDIWDVLIEIVAALHHAEGGIKRQWLIDAVEISCVSSHPSTAIIFVGLLSSICCEYMPFLNLDRSTVLSDMSVTVTSLLSDPSYEVVTEPFISFLWTSLERVYSFATESDANARLSSQQIAQSERDKAPMLVKVMHYICVAFRDHLPLEKQLRLASMDMS
The following text describes a protein:
Function:
Bifunctional enzyme involved in the salvage pathway which converts free L-fucose to GDP-L-fucose. Catalyzes two successive reactions, the ATP-dependent phosphorylation of L-fucose to L-fucose 1-phosphate, and its guanylylation to GDP-L-fucose. The sugar-1-kinase activity has a strict substrate specificity for L-fucose and ATP. The pyrophosphorylase activity has a strict substrate specificity for L-fucose 1-phosphate and GTP.
Sequence:
MSKQRKKADLATVLRKSWYHLRLSVRHPTRVPTWDAIVLTAASPEQAELYDWQLRRAKRMGRIASSTVTLAVPDPDGKRIGSGAATLNAIYALARHYEKLGFDLGPEMEVANGACKWVRFISAKHVLMLHAGGDSKRVPWANPMGKVFLPLPYLAADDPDGPVPLLFDHILAIASCARQAFQDQGGLFIMTGDVLPCFDAFKMTLPEDAASIVTVPITLDIASNHGVIVTSKSESLAESYTVSLVNDLLQKPTVEDLVKKDAILHDGRTLLDTGIISARGRAWSDLVALGCSCQPMILELIGSKKEMSLYEDLVAAWVPSRHDWLRTRPLGELLVNSLGRQKMYSYCTYDLQFLHFGTSSEVLDHLSGDASGIVGRRHLCSIPATTVSDIAASSVILSSEIAPGVSIGEDSLIYDSTVSGAVQIGSQSIVVGIHIPSEDLGTPESFRFMLPDRHCLWEVPLVGHKGRVIVYCGLHDNPKNSIHKDGTFCGKPLEKVLFDLGIEESDLWSSYVAQDRCLWNAKLFPILTYSEMLKLASWLMGLDDSRNKEKIKLWRSSQRVSLEELHGSINFPEMCNGSSNHQADLAGGIAKACMNYGMLGRNLSQLCHEILQKESLGLEICKNFLDQCPKFQEQNSKILPKSRAYQVEVDLLRACGDEAKAIELEHKVWGAVAEETASAVRYGFREHLLESSGKSHSENHISHPDRVFQPRRTKVELPVRVDFVGGWSDTPPWSLERAGYVLNMAITLEGSLPIGTIIETTNQMGISIQDDAGNELHIEDPISIKTPFEVNDPFRLVKSALLVTGIVQENFVDSTGLAIKTWANVPRGSGLGTSSILAAAVVKGLLQISNGDESNENIARLVLVLEQLMGTGGGWQDQIGGLYPGIKFTSSFPGIPMRLQVVPLLASPQLISELEQRLLVVFTGQVRLAHQVLHKVVTRYLQRDNLLISSIKRLTELAKSGREALMNCEVDEVGDIMSEAWRLHQELDPYCSNEFVDKLFEFSQPYSSGFKLVGAGGGGFSLILAKDAEKAKELRQRLEEHAEFDVKVYNWSICI
The following text describes a protein:
Function:
Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
Sequence:
MIYYTGKNGQLGWELAERFKSNGLEAVGFGREEWDLADLDSAARILKDSPRILVHCGAYTAVDKAESDSENAYKINSLSVKKISEECLKRKIHLIYVSTDFVFDANSETIGDTIRFWKPDSTLSPKGIYGLSKAEGEKWIRNTFVDSKQANIVRTSWVYSSHGNNFPKTIVKLLQDSNRHELRVIEDQLGRPTWAGRLADFIIFLIYGILKGESYPEILHFSNSGVASWYDFALAVRDFSHSFSLIENLKPIYPIPTEGYPTPAPRPRYSILDLEETRKIFGVVPHWREDLTLCLKELAEVSGKKV
The following text describes a protein:
Function:
Regulates clathrin-mediated endocytsois of cargos such as transferrin probably through the association and modulation of adaptor protein complex 2 (AP-2) (By similarity). Has a role in ciliogenesis and is required for proper cephalic and left/right axis development.
Subcellular Localization:
Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MMIDDFETHAARSSGDLWSEVCSSLPEPREQHGGQFTDSFEPSSPGDPHTDSPRAANFSPWEPMADSEVYIAGLENRLKRIKGQTSEVTSREMLRSLSQAKKECWDRFLHDAQTSELFQEGNFDQSALEQFKRWLSPERVAINAEELEYLLLPTQNSETPASSSQTDKPCVEEEEECPSPEK