lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MPPSVRYFFIVSVTTVIVFIVLYVLSFGGDQSYQKLNISDSVMLAQVCSSFIDGKSRFLWRNKLMIHEKPSCTEYVTQSHYITAPLSQEEVDFPLAYVMVIHHNFDTFARLFRAIFMPQNIYCVHVDEKATAEFKGAVEQLVSCFPNAFLASKMEPVVYGGISRLQADLNCIKDLSTSEVPWKYAINTCGQDFPLKTNKEIVQYLKGLKGKNLTPGVLPPAHAIGRTRYVHREHLSKELSYVIRTTALKPPPPHNLTIYFGSAYVALSREFANFVLRDPRAVDLLHWSKDTFSPDEHFWVTLNRIPGVPGSMPPNASWTGNLRAVKWMDMEAKHGGCHGHYVHGICIYGNGDLQWLINSQSLFANKFELNTYPLTVECLELRLRERTLNQSEIAIQPSWYF
The following text describes a protein:
Function:
Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. Chemotaxis involves both a phosphorylation-dependent excitation and a methylation-dependent adaptation. CheV and CheW are involved in the coupling of the methyl-accepting chemoreceptors to the central two-component kinase CheA; they are both necessary for efficient chemotaxis. Moreover, CheA-dependent phosphorylation of CheV is required for adaptation to attractants during B.subtilis chemotaxis.
Domain:
Consists of two domains: an N-terminal CheW-like coupling domain and a C-terminal two-component receiver domain.
Sequence:
MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVEVTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVGSVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDTYNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNLAENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRGEVVGADEQISKPEISDLIKKVDTYVIE
The following text describes a protein:
Function:
Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source of carbon. Is also able to oxidize D-lactate ((R)-lactate) with a similar rate. Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as a primary electron acceptor during glycolate oxidation is unknown.
Subcellular Localization:
Cell inner membrane. Note=Glycolate oxidoreductase activity was shown to be firmly associated with the cytoplasmic membranes.
Sequence:
MSILYEERLDGALPDVDRTSVLMALREHVPGLEILHTDEEIIPYECDGLSAYRTRPLLVVLPKQMEQVTAILAVCHRLRVPVVTRGAGTGLSGGALPLEKGVLLVMARFKEILDINPVGRRARVQPGVRNLAISQAVAPHNLYYAPDPSSQIACSIGGNVAENAGGVHCLKYGLTVHNLLKIEVQTLDGEALTLGSDALDSPGFDLLALFTGSEGMLGVTTEVTVKLLPKPPVARVLLASFDSVEKAGLAVGDIIANGIIPGGLEMMDNLSIRAAEDFIHAGYPVDAEAILLCELDGVESDVQEDCERVNDILLKAGATDVRLAQDEAERVRFWAGRKNAFPAVGRISPDYYCMDGTIPRRALPGVLEGIARLSQQYDLRVANVFHAGDGNMHPLILFDANEPGEFARAEELGGKILELCVEVGGSISGEHGIGREKINQMCAQFNSDEITTFHAVKAAFDPDGLLNPGKNIPTLHRCAEFGAMHVHHGHLPFPELERF
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Specifically cleaves 'Lys-48'-linked polyubiquitin.
Sequence:
MANEPQKSDDNGQAAEAVVTDDEIVLQDQQLKTIEDEQKSVPLVATLAPFSILCAEYDNETSAAFLSKATELSEVYGEIRYIRGDGNCFYRAILVGLIEIMLKDRARLEKFIASSRDWTRTLVELGFPDWTCTDFCDFFIEFLEKIHSGVHTEEAVYTILNDDGSANYILMFFRLITSAFLKQNSEEYAPFIDEGMTVAQYCEQEIEPMWKDADHLAINSLIKAAGTRVRIEYMDRTAAPNGGWHYDIPSDDQQIAPEITLLYRPGHYDVIYKKDSTEASEIEN
The following text describes a protein:
Function:
Negatively regulates the transcription of the fatR-cypB operon. Is displaced from its operator by a range of fatty acids such as oleate, linoleate and phytanate, thereby allowing transcription of the fatR-cypB operon.
Sequence:
MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTIYRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALFFLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKIYQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK
The following text describes a protein:
Function:
May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPRGFLVKRSKRGSSASYKVRAEETEPRKEDLNTQTPNASVLEPIRESWTSEISSKHEETRLLEDAGGSADYAQNYFIHPEQSASSPRNTCDSYSPIKPISTELLDRCLSSPAMAESFPLVTPVSSIERLLMNHSDMKFGTPVPSSVPTYPALHQCVKRAFMDSERKSKPPKKPKVIRKLNFEDEVTTSPVLGLKIKKESPETKLPPQGGRKKPLGEFICQLCKEEYPDPFSLAQHKCSRIVRVEYRCPECDKVFSCPANLASHRRWHKPRTLSTADTKKSQLEARNLEKTSSVEGKENASKMRVNNQHQLSPDSSQLHRSAPDSSMMHRDPPLDQRFSTPEKCFEMHIGSAEASRLFDHCPEEPDRSPATPYLPSPGPEEVYDCHYCSKKFRRQAYLRKHLAAHETIKASSYGQIESGQITFPCHLCGAHFPSAEIRDKHRLWHAVREDLLLRPDLSPAAGDQQIFSCKHCPSTFFSSPGLTRHINKTHPSESRQVMLLQMAVRPGC
The following text describes a protein:
Function:
A flexible structure which links the flagellar filament to the drive apparatus in the basal body.
Subcellular Localization:
Bacterial flagellum basal body.
Sequence:
MSYVSLSGLSAAQMDLNTTSNNIANANTFGFKESRAEFGDVYSTSLFTNAKTTPGQGVQAAKVAQQFHEGSSIYTNNPLDLRIAGTGFFAVAKDRLVPQQNELTRNGAFHLDKNSFMVTANDEFLLGYEVNPDTGDVLSYEPKPINIPPQFGKPKQTANIDLGANLPANGDLKDPALFDITDPETYNRTTSSTIYDSMGQPYKLTTYYLKDMNQANTWQTYYTVTDKTGEKPINVVGGDAASPTGHVGHTMRFNNDGTLSSLNNGQPIVTEPLGGGANPVDLNGADVNQTLSFSLDSATQFAAPFELTKFDQDGATTGFLTKIDFDENGSVLATYSNGINTTLGRVALVRVANEQGLDKKGGTQWDATQFSGAKIWGESNKGSFGSISNGSLEQSNIDMTQELVDLISAQRNFQANSRALEVHNGLQQNILQIR
The following text describes a protein:
Function:
Salivary chemokine-binding protein which binds to host chemokines CCL1, CCL2, CCL3 and CCL5.
Subcellular Localization:
Secreted.
Sequence:
MALKACITVIAVVYVVQVVRGAEKSLDSDSSGEDYELWTQGCPFLVAENRTGFGTTVSCQHNCNGAIEKVPEGEPCYTIGEDGLGRMKLNLPYNCSLGECSGGVCVPNGRSDVCFKRTWEENNKAMA
The following text describes a protein:
Function:
Coordinates growth and maturation by mediating endocrine responses to the attainment of critical weight during larval development. Plays a central role in the genetic cascades triggered by the steroid hormone ecdysone at the onset of metamorphosis, acting as both a repressor of the early ecdysone-induced regulatory genes and an inducer of the ftz-f1 midprepupal competence factor.
Subcellular Localization:
Nucleus.
Sequence:
MTLSRGPYSELDKMSLFQDLKLKRRKIDSRCSSDGESIADTSTSSPDLLAPMSPKLCDSGSAGASLGASLPLPLALPLPMALPLPMSLPLPLTAASSAVTVSLAAVVAAVAETGGAGAGGAGTAVTASGAGPCVSTSSTTAAAATSSTSSLSSSSSSSSSTSSSTSSASPTAGASSTATCPASSSSSSGNGSGGKSGSIKQEHTEIHSSSSAISAAAASTVMSPPPAEATRSSPATPEGGGPAGDGSGATGGGNTSGGSTAGVAINEHQNNGNGSGGSSRASPDSLEEKPSTTTTTGRPTLTPTNGVLSSASAGTGISTGSSAKLSEAGMSVIRSVKEERLLNVSSKMLVFHQQREQETKAVAAAAAAAAAGHVTVLVTPSRIKSEPPPPASPSSTSSTQRERERERDRERDRERERERDRDREREREQSISSSQQHLSRVSASPPTQLSHGSLGPNIVQTHHLHQQLTQPLTLRKSSPPTEHLLSQSMQHLTQQQAIHLHHLLGQQQQQQQASHPQQQQQQQHSPHSLVRVKKEPNVGQRHLSPHHQQQSPLLQHHQQQQQQQQQQQQHLHQQQQQQQHHQQQPQALALMHPASLALRNSNRDAAILFRVKSEVHQQVAAGLPHLMQSAGGAAAAAAAAVAAQRMVCFSNARINGVKPEVIGGPLGNLRPVGVGGGNGSGSVQCPSPHPSSSSSSSQLSPQTPSQTPPRGTPTVIMGESCGVRTMVWGYEPPPPSAGQSHGQHPQQQQQSPHHQPQQQQQQQQQQSQQQQQQQQQQSLGQQQHCLSSPSAGSLTPSSSSGGGSVSGGGVGGPLTPSSVAPQNNEEAAQLLLSLGQTRIQDMRSRPHPFRTPHALNMERLWAGDYSQLPPGQLQALNLSAQQQQWGSSNSTGLGGVGGGMGGRNLEAPHEPTDEDEQPLVCMICEDKATGLHYGIITCEGCKGFFKRTVQNRRVYTCVADGTCEITKAQRNRCQYCRFKKCIEQGMVLQAVREDRMPGGRNSGAVYNLYKVKYKKHKKTNQKQQQQAAQQQQQQAAAQQQHQQQQQHQQHQQHQQQQLHSPLHHHHHQGHQSHHAQQQHHPQLSPHHLLSPQQQQLAAAVAAAAQHQQQQQQQQQQQQQAKLMGGVVDMKPMFLGPALKPELLQAPPMHSPAQQQQQQQQQQQQQQASPHLSLSSPHQQQQQQQGQHQNHHQQQGGGGGGAGGGAQLPPHLVNGTILKTALTNPSEIVHLRHRLDSAVSSSKDRQISYEHALGMIQTLIDCDAMEDIATLPHFSEFLEDKSEISEKLCNIGDSIVHKLVSWTKKLPFYLEIPVEIHTKLLTDKWHEILILTTAAYQALHGKRRGEGGGSRHGSPASTPLSTPTGTPLSTPIPSPAQPLHKDDPEFVSEVNSHLSTLQTCLTTLMGQPIAMEQLKLDVGHMVDKMTQITIMFRRIKLKMEEYVCLKVYILLNKEVELESIQERYVQVLRSYLQNSSPQNPQARLSELLSHIPEIQAAASLLLESKMFYVPFVLNSASIR
The following text describes a protein:
Function:
Functions as an auxiliary enzyme in the beta-oxidation of unsaturated fatty acids with double bonds at even carbon positions. Catalyzes the NADPH-dependent reduction of the C4-C5 double bond of the acyl chain of 2,4-dienoyl-CoA to yield 2-trans-enoyl-CoA. Acts on both isomers, 2-trans,4-cis- and 2-trans,4-trans-decadienoyl-CoA, with almost equal efficiency. Is not active with NADH instead of NADPH. Does not show cis->trans isomerase activity.
Miscellaneous:
MISCELLANEOUS: The overall reaction mechanism can be divided into three stages: initially, reduction of FAD by NADPH, then electron transfer from FAD to FMN via the 4Fe-4S cluster, and finally reduction of substrate.
Domain:
Is composed of three domains: an N-terminal TIM barrel (residues 1-368) which binds FMN, the 4Fe-4S cluster, and the substrate; a flavodoxin-like fold (residues 369-467 and 626-671) which binds FAD; and an NADP(H)-binding domain (residues 468-625).
Sequence:
MSYPSLFAPLDLGFTTLKNRVLMGSMHTGLEEYPDGAERLAAFYAERARHGVALIVSGGIAPDLTGVGMEGGAMLNDASQIPHHRTITEAVHQEGGKIALQILHTGRYSYQPHLVAPSALQAPINRFVPHELSHEEILQLIDNFARCAQLAREAGYDGVEVMGSEGYLINEFLTLRTNQRSDQWGGDYRNRMRFAVEVVRAVRERVGNDFIIIYRLSMLDLVEDGGTFAETVELAQAIEAAGATIINTGIGWHEARIPTIATPVPRGAFSWVTRKLKGHVSLPLVTTNRINDPQVADDILSRGDADMVSMARPFLADAELLSKAQSGRADEINTCIGCNQACLDQIFVGKVTSCLVNPRACHETKMPILPAVQKKNLAVVGAGPAGLAFAINAAARGHQVTLFDAHSEIGGQFNIAKQIPGKEEFYETLRYYRRMIEVTGVTLKLNHTVTADQLQAFDETILASGIVPRTPPIDGIDHPKVLSYLDVLRDKAPVGNKVAIIGCGGIGFDTAMYLSQPGESTSQNIAGFCNEWGIDSSLQQAGGLSPQGMQIPRSPRQIVMLQRKASKPGQGLGKTTGWIHRTTLLSRGVKMIPGVSYQKIDDDGLHVVINGETQVLAVDNVVICAGQEPNRALAQPLIDSGKTVHLIGGCDVAMELDARRAIAQGTRLALEI
The following text describes a protein:
Function:
Part of the chromatin structure-remodeling complex (RSC) which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and required for cell cycle progression (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGEKPNRIGRANISYINHDHIFLPSFQPSYPSRQLHPLISSQNKVHSSIVHLPKVASPSSPETQQHSQAPLFITHIMSGLPQALASGFAARVREGGTTLYINTTPMLRSARHNTAVNYAEFEEDFDANDFEDDDDDDQSQRESRDGSEEAEGDEDGTKKEEQDKFAGLKAPLVSNEPKRAAPPVRPVMYPQEVLEELSQVKEPTLIPIRVAVENIDVFRVQDFFLWDADEKILTPEQFATLTCADLDVPIGYSAQMSAQIKKQLAEYTAAPALPKDVEVHVIVELAVTVDKIVYEDKFEWDLSGEYATPQEFARTVVQDLGLGQEFYPAITYQLYETLGKLQKAWLERSIPLDVDNRAAFGLEAGLRVDQDNLGESWVPRVEEMTPEEMQKREMERDRSSRRLKRESARMAEVPYVDLDSLYSRKRRRRFDEDSRSGSPMW
The following text describes a protein:
Function:
Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling; May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MASAGGEGAVLVPLARRCGGCDGREEAVVEAMLQWQKVSDLLIAASLLSIPLELLYFATCAALAPLRRVLLQLGTFIVMCGVTHLLNVLAYDHPGSHRILVALTTAKILGALATSAAAVSLPVLFPRLLRLKVRESFLRTKARQLDRDLATVRHREETVWRVVRAVTHHIRDSIDARTILRTTMLQLAAALGLSNCAIWMPQPGGSDRGVLQLMDQLLPDRDDEGDKVLHHSGGTRAISVRDPDVAAVLASKDAKVLSRPGSALKAASCRSVPLAGAAAAIRIPNFHGEVGSRNTSEPLSYAILVLVLRAHEDQHRAPTGWSNLDLEIVQAVADQVTVALSHAAALEESQLIRHRLAEQHGALLRARSELAAATKARNNAHSAMRSAMGRPMHSVVGLISVMQQEAAAMRPEQRLIVDAIARTNAVSSTLMDDVMETLQRMVDIRDPPLSTPTPTLVSRRPFELRSLIRDAAFVARCLSGCQELGFSHQLQANSLPEWVVGDDKRVFHLVLHMVGAQLSRCHGQHVTAAGRTLSFSVCSCNSIASEHQDWIPSPLRPVSFTSGNQVFVRIQIGLTKSGPGSSPASRPPQCGLSSDSGGANMRLTFAMCKKIVEMMNDDMWWASESEGQGETMTCILRFQQQQPPNPHVPGSGTYRIGASSATAAPHLHFNGLRILLADSDAMSMEVTRKLIERLGCQVLPVSSGADCLSLLRGAEPSFELVVLDLDGHGGAGTAGAMDGLEVALRIRELSNTCWLLVLVAVEASGVDDTVRDMCRRAGVDGLIHKPITLPALGAQLQRVLQNN
The following text describes a protein:
Function:
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
Subcellular Localization:
Cytoplasm.
Sequence:
MKRIAFVFSTAPHGTAAGREGLDALLATSALTDDLAVFFIADGVFQLLPGQKPDAVLARDYIATFKLLGLYDIEQCWVCAASLRERGLDPQTPFVVEATPLEADALRRELANYDVILRF
The following text describes a protein:
Function:
Required for normal Golgi function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MPETLLHSVSVSSIFPSKPINFVQKYLSGVPAGRKNGARNSKDGKIEEKEEKEFDFSRKIRELRLELEIKKREEERIEKDIAIILEENTIDGGEQNRSFGLAVTRLNNNMLVVENSAKQLTSALKNISSLADTISGRVSALDVAKTRVVGCLQLAGDMRDLGVCAEGIDDAIRSEDFEIASQHIHRFLTLDQAVFQIREFKQKDATDSIRHSYEVLSSAKDRLSKILKSRLTEAVQKGDVAEMQRFVKLFPLIHEADEGLQRYSVFLNQKIDKLAEENLAIMRAGGTDDNRRNVLYADTLFMFFEGVAEIIESNLPVLEHSYGLEKLLDFMFILQARIDEFFRRLIEEFDTRRRLSHLNRQVADVVHHKKFTAPEGLEDVPDALEVDAIASEICMMNTSVEMYWRFVSRRIGKNDADLARSPSGDGDEEEDEEARLERQRLRKEAKEQKMDQLLNRSRVGTKMQELIGHYCLLEHFYMMKSVQKAIKSDAKEDVGTLTSSLVDDVVFIIRKSIRRAAGSGNVDSVCATINNATALLDTVVHGSLHHDIQSGYVTSSNFASEAFIAYQQGKQVKEAAESQKEQFLLAVNNSAKLSELLIELQKGLISEWAGVKRPAVEKNKLEHSTTQIEESARKLAALAKHGVEELFKSAFKSRIRQGLADPYQNIDRQMTMQDVEYYEAHDPFMEHFLAQIDRLLVENEPNLFPDNYQTILLLTATEIARQIEGAVAKCQFNRYGALQLDREYRQICAYLTNVAGWSAREKIGRLGQIVALLNVETVDEAMEVWHNSKTMTTSTIRALSLPEVRKILALRADFPTVAIKSIE
The following text describes a protein:
Function:
Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Microsome membrane.
Sequence:
MNARGLGSELKDSIPVTELSASGPFESHDLLRKGFSCVKNELLPSHPLELSEKNFQLNQDKMNFSTLRNIQGLFAPLKLQMEFKAVQQVQRLPFLSSSNLSLDVLRGNDETIGFEDILNDPSQSEVMGEPHLMVEYKLGLL
The following text describes a protein:
Function:
Required for the formation of pollen coats and male fertility.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, pollen coat. Note=Localized in small granules in the tapetal cells.
Sequence:
MCSKITLVLTLFSSYFISTDAVNGSFPALLAFGDSILDTGNNNFLLTFMKGNIWPYGRSFSMRRATGRFGNGRVFSDIVAEGLGIKKILPAYRKLFNSPSDLRTGVCFASGGAGVDPVTSKLLRVLTPKDQVNDFKGYIRKLKATAGPSRASSIVSNAVILVSQGNNDIGISYFGTPTAAFRGLTPNRYTTKLAGWNKQFMKELYDQGARKFAVMGVIPLGCLPMTRIFLGGFVITCNFFANRVAEQYNGKLRSGTKSWGREAGFRGAKFVYVDMYNTLMDVIKNYRRYGFSNEKNGCCCMITAIIPCPNPDKYVFYDFVHPSEKAYRTISKKLVQDIKNGLA
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MTVEDNLDIDFSDLEEKYAVNADEGFESFIVVDGAPVIPQAKQAALANVMKKFFGAVGKIKEDGIFIPFDEATGKSTGFVFIEYETGEMAAAAVKSFHNKQFDKNHKLLVNKLSEVEKYGMQYDTLKTEEFVEPETEPFVEQGHLRSWLMDPQGRDQFVLHRGDTVGVFWNKKGDTLEADVDRERWTETQVYWSPTGTYLVSTHTQGVQLWGGPDWAPPICKFQHPNVKMVQFSPCEKFLVTWSNVPLVLPDDEEKRKSIPFGPADEGKQIIVWNLETRLPVRTFAMPPEKKGASMSWPILKFSPDDKYAARMIPGEQLSIYETETMSLLDKKSVKAPGIVDFEWAPALVNLEGRQKSATESVLCYWTPEIGNQTARVVLMKASNKEVLRTRNLFNVADCKIHWQDQGRFLCVKVDRHTKSKKSTFTNLEFFRLCERGVPVEVMELKDTVTNMAWEPHGDRFVTISNSDSTTNYDGPLPANRHTLSFYALERHKGTQGTWKLIKAFDKKNCNSLFWSPNGRFLITVMIEGSNSIDLDFWDMDYEGDRKHGDKDLPANLHFLGSSEHYGISALEWDPSGRFVATWSSYWRHHTENGYKIWDFRGQLQREESIDRFKHFSWRPRPPTLLSKQQKKDIRNNLEEYSRKFEEIDAMEASEASRELIMLRKRLLEEWTAWRAQTDKKLEELGLVEPEPAESEYTTIEEIKEVVVEDKEEVCE
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLDTSSSAIHLQLPPTSSSLRPPSQITVHPSVIAQILTHHSRHSADSESTRVIGALMGNRSDNGQEVDIRSCFAVPHTEQGQQISVDRPFQQDMVNFLAKNGTKEVIVGWYASQKTVNSNSAIIQEYFSFETNPYPAVHLTVDTDIEESGKGLGVKGWVSQPLGLTSKSECSVFVPVPVSIKYADSERAALDLLTAPQPTPSPALPPLPTLSNSLSQLSSLIDQCLAYVQSVNNGSQTPDVEIGRYLLEGLGRWSASGNEDEGGVKAGLQDTLTVEYLSSLVRSQVELAGRLSLLQQPVAQQ
The following text describes a protein:
Function:
Putative cation exchanger.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MHKPLRWLITIAFYVSNVILIGYSLSSNGSISEFYLHSVVLIECFSLLGVVTSDCLTPSLSYISSNIFHISDRVSGMTLLALGNALPDITSTYQSMKSGVTSLAIGELFGGIFFLLTVVIGLMGCVATIQFQHDKSIETYTEESFDQNLSYDRSNYILDVGIFTFMLLVSGTFLADGRLYFWECIVMVLTYCCCAVYLIKSYKYPCEINDALEREVEIKKTVLANNHITVPNRFTLTTTSDITSTDDGIRYVRPLGDTQIDEDNAISLDPTRLPSKSLDNISRFNQGIPERRDLIRRRIRGYLRSHYHGWVRMTLQDLLNIWEKQNLFNNTVKSLSLPSDDTHLFTKASLDEEGRPLIRKRMNSLQPKDFYKYLSLRNGENSNALDTAISAPQNEYQTYYNEPTSLFLTVPQKKTSKKSLSCDRIPNLVRSNNIILNDEATRTQESTNALNSISDVIDNSLLQYERDDIILDRTLSLCSTKSRTAWHSFQLYNYLTDVSLEIGFFEFLSLLVTTPVSIILYLSIPSEISQTDHDLPLSYLQNIQLIASPIILNQLITNNFSFWLLILSLVIAILLYFKTRTIPNKFNSDIIFTVAFLLSLACLSKAVHIIVVTLTHWINVFNISETILGLTIFTWGNSIGDLVSNITFVKIGVLEIAIGACFGSPLLYFLFGVGFDGIMIMLGDKTGKIVSGRDSNILMHHIDFKVDKNLINTGVGILIAFLIFTVLIPLNDWKIDKKISIALLTLYIVVTCISVFLEVHQV
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MKVIFKVRIIFRKRGFNGGLSFLGKAFRVGRHFCISQDHSTSMIRFHRLLGMRVCGSDSINYPKDGKTLTSHSFYSFLDSIAMKKKTQSKVPHFIVFQKTINLFADRFPKTAETFCIVSTGEKEFGYKGSCFHSIILGLMCQGGDFTPYNSTSGKSINGEKFDDEDFKHTGPGTLSMANTGLNKTVPTRGLGNVKEDVNIVRAMENSGSRMSRPARSSPLSTVNNSNKFDLYFILATKPFFLQLSLEILPVSLH
The following text describes a protein:
Function:
Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1. Binds to the PRKD1 promoter. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.
Subcellular Localization:
Nucleus.
Sequence:
MNITCGRQAMHKDVTMYPLSVRSASNNHSAQNYASNQPYFNYVTYHHVPPMDEQGQPCGVWGPQYGSPREQWNSYGAGPSNTNMAQSSDLSPNQFAYNSSGYSSPHPSGTGILHSVDLSHTAANSPSDLSQNSYEWMGKTVQSTSTGKTRTKEKYRVVYTDHQRLELEKEFHYSRYITIRRKTELAASLRLSERQVKIWFQNRRAKERKLFKKKMNQFDGICSVQSDSSSASPNPLCDSVVHTDMSGSLYQPPPIALNGL
The following text describes a protein:
Function:
Selective transporter that mediates the uptake of Zn(2+). Plays an essential role for dietary zinc uptake from small intestine. The Zn(2+) uniporter activity is regulated by zinc availability. Also exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
Sequence:
MASLVSLELGLLLAVLVVTATATASPPAGLLSLLTSGQGALDQEALDGLLNTLADRVHCANGPCGKCLSVEDALGLGEPEGSGLPPGPVLEARYIARLSAAAVLYLSNPEGTCEDARAGLWASHADHLLALLGSPKALTPGLSWLLQRMQARAASQTPKTACVDIPQLLEEAVGAGAPGSAGGVLAALLDHVRSGSCFHALPSPQYFVDFVFQQHSSEVPMTLAELSALMQRLGVGREAHSDHSHRHRGASSQDPVPLISSNNSSSVWDTVCLSARDVMAAYGLSEQAGVTPEAWAQLSPALLQQQLSGACTSQSRPPVQDQLSQAERYLYGSLATLLICLCAVFGLLLLTCTGCRGVTHYILQTFLSLAVGALTGDAVLHLTPKVLGLHTHSEEGLSPQPTWRLLAMLAGLYAFFLFENLFNLLLPRDPEDLEDGPCGHSSHSHGGHSHGVSLQLAPSELRQPKPPHEGSRADLVAEESPELLNPEPRRLSPELRLLPYVITLGDAVHNFADGLAVGAAFASSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVRQALLLNLASALTAFAGLYVALAVGVSEESEAWILAVATGLFLYVALCDMLPAMLKVRDPRPWLLFLLHNVGLLGGWTVLLLLSLYEDDITF
The following text describes a protein:
Function:
Possible component of hydrogenase 4.
Sequence:
MNVNSSSNRGEAILAALKTQFPGAVLDEERQTPEQVTITVKINLLPDVVQYLYYQHDGWLPVLFGNDERTLNGHYAVYYALSMEGAEKCWIVVKALVDADSREFPSVTPRVPAAVWGEREIRDMYGLIPVGLPDQRRLVLPDDWPEDMHPLRKDAMDYRLRPEPTTDSETYPFINEGNSDARVIPVGPLHITSDEPGHFRLFVDGEQIVDADYRLFYVHRGMEKLAETRMGYNEVTFLSDRVCGICGFAHSVAYTNSVENALGIEVPQRAHTIRSILLEVERLHSHLLNLGLSCHFVGFDTGFMQFFRVREKSMTMAELLIGSRKTYGLNLIGGVRRDILKEQRLQTLKLVREMRADVSELVEMLLATPNMEQRTQGIGILDRQIARDLRFDHPYADYGNIPKTLFTFTGGDVFSRVMVRVKETFDSLAMLEFALDNMPDTPLLTEGFSYKPHAFALGFVEAPRGEDVHWSMLGDNQKLFRWRCRAATYANWPVLRYMLRGNTVSDAPLIIGSLDPCYSCTDRVTLVDVRKRQSKTVPYKEIERYGIDRNRSPLK
The following text describes a protein:
Function:
Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
Sequence:
MSKFFDPFKILKAPISTEKAVRMINEENKLAFYVDIKASKSEIKRAVEEAFDVKVVSVRTLITSTGRKKAYVKLSPEFKASDIASKLGVIG
The following text describes a protein:
Function:
The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDDNKPKSNTFTDEGRLPQVEFAIKNVSRAGTIIGYVCSDGVVLMGVNKEPTNGPMEKIYQLSDSIYCVLCGLFGDAMELKRYARIKAQEVLERFGVECPLTTLCKFVGQRKQAFTQYAGTRPFGVSFLYAGVIDGKYALMSTDPSGTSNRWKGMCYGENEEAINRGLKNDFPEDEMDMKTATVEILRLLGKARELGPKEADRLEILHFSKDCKKYLPCDEVLKLLEEIHAK
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Sequence:
MASSTSIPCPASTFMLSHAQLAAMEEWAFLTHLHLHRSSRPQSQQSFLQARQHRYPSIPAYNFQATLSTIPPSSLVLFPAWCKAHSLDSGKHTSYAQYLSEVNLLPYEGDPADYPGLYHFVCMIHCGTNRFEGFERKDQMSVRWILNCFYESRYLADFGGLGDVVGGRWSIVATLTNDSGDCNRGIHKVHEYATPGPVRLMKVLASEALWPGHSAREIGILATLRGGCANIVQSFDSYTPSGRHDLPWLIMEMCNAQSLWNRAKKYWKAEEDVPELFIWHVFISLLEAVKYCHYGPGEEDWDPIYHRDITLSNVLLHYPTDDKTGYPDVKLADFGCAVTRSEATAKQLKIADMPEVCPSAIPPEGALAAKATDMYQVGAIVKELMEKERNSHGRALVRTYSKTLQYLADCCTILLAAKRPDAASMLRIVRTNRDDLLAAGSVRHERLRGE
The following text describes a protein:
Function:
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of the anamorsin/DRE2 homolog, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MSNPLLILYGSQTGNAQDVAERIGREARLRLYSPRVVAMDSYDVTSLPAEPLVVFVTATTGQGEPPDNMRRFWRFLLRKSLPPDSLAGLRFGVFGLGDSGYPQYNVMAKKLDRRLEGLGARALLERGLGDDQHPSGFEAALDPWLTRLWPALRVVSPLPAGVPEPVVSEDALLELGPPKFRVTLLPRGGEAEAAARRALAARLAAEQPQVRGLAAVVLARGCSSSANGSSSSTNDSNGSSAMEDGGAQPKYLAQAADTAPADGAVGGGGGRLAHCRLAEAAAAATDFRRLLQAAAGAAPPDAGITAAQTPNGTPSGNGSASAAAVSYGPWRPYLARLVCNQRITAPDHFQDTRHVELDLEGSGLSYEPGDVISVLPMPSEAVADAFLTRLGLDGDQWARVELAAEGSGQDGSTAGLQQEQQEQEQGQQGAGGAGAAGVGPCAFTARVRSLVTGCLDIGGGSPRRYLFQVLLQSATAEHERERLSYFATADGRDDLYRYNQREGRTLLEVLQDFRSCAPPLARLLEAAPHLRPRQFSAASSPRLRGPAAAQLLVALVSYVTPYKRSRQGLCSAYLAGLEPKEGGEEVRVAVWTERGSLRMPRSLQTPLILVGPGTGVAPFRSFLEERCALARQAHAAGQPPPAPCFLFFGCRSPAADFYYQAQWEEYRRLGVLDREHGLITAFSRHTPEQQAQQGQAVQGQQAQGQGKGQEKGEGGEQQNAGAAAAPTSKVYVTQRIREHGALVWRLLNGLPPAAAAAPATAAVDNPATAAAAAPTAVHSAHSGAGEAAAQAAAPAAAAMEPAVVYVSGSAQKMPAGVAAAFADVAVAHGGLDKEAAAAWVRQLELRGRYFVEAWS
The following text describes a protein:
Function:
Required for motile ciliogenesis and flagellar genesis by mediating the maturation of the glycolytic enzyme ENO4.
Miscellaneous:
MISCELLANEOUS: Named Hoatz according to the Hydrocephalus and Oligo-Astheno-Terato-Zoospermia phenotype of Hoatz knockout mice.
Subcellular Localization:
Cytoplasm. Cell projection, cilium.
Sequence:
METGPRGCPSGRKESQEICSPGLLVFTGCSEQDANLAKQFWLGASMYPTTESQLVLTRGSSQRLPVARNSKVVLREKSSVQPFPFDQDKDAIIFAKAQRIQESEERAKYLQKAKTRDEILQLLRKQREERISKELISLPYKPKDKVPKSKEVLSESGLRDQEEVKALE