lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MTNTLDDSIGSMQNCVSIVRDTSLKLRSRAQTPEETERIKKVLQLTRKYEEVTQSEVLAAQQRQAAEIAPQVQDLIGGVEKQISSLHSKERKLKSQSELNKSRLEQFPMTRREVVDVPRDADNVVEVTEEELQELEELQREREKLKMEISRLNLEKRKSVYGKLPQ
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MASTDSEETINVLFYGLGAIGSVYAFILSRCPNVRLTAVARSNYDAVRENGLKLISENHGENTFYPANVIKTPSEAPGHYDYIVCSNKAIDQEVVAKALSPIISTSTSIVLIQNGVGNEEIFQKLYPQNSIISCVAWTGAIQKTLGIVHHTKNENLQLGLFRNDNIPESTSSQQLKIFDDLLTTGKTPHEVFSPERLQIARWEKVTWNCAWNCLTTLTRTHTHEWLNSSPEAMKMTRALMQEIIEVGRKMGVGIKDDLIERLMERILRMPSIGTSMLTDVLAGRRLELDVILGFPVKKGRELGVDMRVAETVYTLLLGVDEGLRVRGLEG
The following text describes a protein:
Function:
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.
Sequence:
MGRNNTLPNDFTVGYYLSDSKINKLKWNLFVDMCKEKYNINVVPIDMNKDINSINTRPYHVIIDKLTDELGDLDNPSNKQKVDYIQSLIDKFPSIVEVDPLESQKPVLSRDTLTKLLDKLNDVSPELNIKNPKFVLVPEDYNNNDYNQLLKDANIKFPVVCKTIKACGSKESHYMGIVFNEKDIHQFKQPMLIQEFINHNAIIYKVFAIGDFIQVVHRKSIRNMNENENELIKFDSQKPFPTSLLPTDGQELKIEMPSKSTLSVISKDIQKNLDISLFGFDVIVDCETKKLAVVDINYFPTFSGVDDFYTLLIEHVINVYKRKSSV
The following text describes a protein:
Function:
May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). The membrane form is involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR. May be involved in centrosome assembly.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cytoplasm. Nucleus.
Sequence:
MALIEGVGDEVTLLFGVVFLVLVLVLAWASTHTVEPPEHLLSPSPGASPSTETDSQEPLPPGNTDSSPGGVRDEDDKSEPGTEAGAAGQSADGSRAGGGDGGLLDDAGLGSDGLRHRESAGPSTHPPESTPSATQPSAEDAASDTHRNMVLRLKFLNDTERTAQVNPQDTIGYIKRTYFAGQEHQVRLIYQGQLLQDDSQTLASLNLADNSVLHCHISQHATRAMPAGARAADQVHVALNVGSLMVPLFVLMLSVLWYFQIQYRQFFTAPATASLVGITIFFSFVAFGVYRR
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor (RshA) until released. This sigma factor is involved in heat shock and oxidative stress responses; it positively regulates the expression of itself, sigE, sigB and a number of transcriptional regulators as well as other effectors of heat and oxidative stress, leading to direct and indirect control of up to 25% of the bacterial genome. Modulates expression of host genes for intercrine beta (chemokine CC) and apoptosis, altering the host immune response.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Domain:
The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA, and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. The sigma-70 factor domain-2 mediates interaction with the RNA polymerase subunits RpoB and RpoC (By similarity); The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA. Interactions between sigma-70 factor domain-4 and anti-sigma factors prevents interaction of sigma factors with the RNA polymerase catalytic core.
Sequence:
MADIDGVTGSAGLQPGPSEETDEELTARFERDAIPLLDQLYGGALRMTRNPADAEDLLQETMVKAYAGFRSFRHGTNLKAWLYRILTNTYINSYRKKQRQPAEYPTEQITDWQLASNAEHSSTGLRSAEVEALEALPDTEIKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQLRGLLADVARDRGFARGEQAHEGVSS
The following text describes a protein:
Function:
Antitoxin component of an atypical, type II toxin-antitoxin chaperone (TAC) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin HigB1. Neutralization of HigB1 toxin in E.coli or M.marinum also requires SecB-like chaperone Rv1957, making this the first toxin-antitoxin chaperone (TAC) system. Antitoxin aggregation and degradation are prevented by the chaperone; In M.tuberculosis represses expression of the Rv1954A-higB1-higA1-Rv1957 operon promoter but not that of the higB1-higA1-Rv1957 operon.
Sequence:
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLSTLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
The following text describes a protein:
Function:
Calcium-selective channel required to prevent calcium stores from overfilling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MIFSQIAITVYSLVCCAISEFITKYFVTDSPVYISLNNEAEALEQKISKLGGYENKKKREKLEKDQATIKQQIAFHKFKPMILNLVFMIASTIAVNYMFKPVKVGKLPFQPFSFFTKVTHRNLPGDDMTDCSLFFFYVLMRMAFKPIMAKLFGNDNVNEASFMNAFVPENETFKSK
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLAVGLVITASFFIYEATSSRKNRSLAKELVIGAVTFVFLGFGSLFLLLSSGVYV
The following text describes a protein:
Function:
Acts as a synthetic multivulva class A (synMuvA) protein and redundantly inhibits lin-3/EGF expression to prevent inappropriate vulva induction.
Subcellular Localization:
Nucleus.
Sequence:
MSKIKTHSTGSKRTVPFYKLPPPVPLPPLPPPDPTRYFSTEKYIALSKDEKFKFDDYDVNDETLKKVVLNEIGKCPDIWSSRSQAAIMEHYPIVATETYRRTGLLLSIKSLKQIYKCGKDNLRNRLRVAIVSKRLTPAQVEAYMWRWEFYGFIRYYRDYTQRWEADLLKDLDVVLGLEARRASKNMEKVDSGELMEPMEPMDSTMDEMCVEEEPYEETGSNWSDPAPEPSQSKSQSPEAKYPQAYLLPEADEVYNPDDFYQEEHESASNAMYRIAFSQQYGGGGSPAVQKPVTFSAQPAPAPVREAPSPVVENVSSSSFTPKPPAMINNFGEEMNQITYQAIRIAREQPERLKLLRKALFDVVLAFDQKEYADVGDLYRDLAQKNS
The following text describes a protein:
Function:
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Sequence:
MNLSCSLVLLGGGKGERFNSLQPKQYTHLCGEPLILHALHAYQRLPFVQEVVVVCEEQYRELFLPYSVKFASPGTLRQDSVFSGLQQVSTPWVCIHDGVRPFVYADEVIEVCSAARKTGAAALASPATYTIKSCAPVRTLDRDALAVIHTPQCLDTEVLREGLLLARAMDFSLSDDTEAAELLGIEPTLVFSNRVQIKVTYPEDLLFAETLLSKSSTYK
The following text describes a protein:
Function:
Involved in the utilization of lactams. Required for the conversion of exogenous 2-pyrrolidinone (gamma-butyrolactam) to endogenous gamma-amino-n-butyrate (GABA).
Sequence:
MAPIKKKALINCDMGEAYGNWTCGPDLELLPLIDIANIACGFHAGDPLIMMETVRNCKAHNILVGAHPGLPDIQGFGRREMKLSPEELTAITIYQVGALQGFLDREGVRLNHVKPHGVLYGMMCRDYEVAKAVMLGIPKGIPVFGLPGTNMEKAANDLGIEFRAEFYGDVKYDSNGMLVIDRKKKPWDPADVEKHVRQQLEDQSVTSVDGVVVPLPIKDYDVSICCHSDSPGCLEIIKTTKKVVDEFNKKYGF
The following text describes a protein:
Function:
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Subcellular Localization:
Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2.
Sequence:
MARCRMPRWGLLLVLWGSCTFGLPADTGAFRRIFLKKMPSIRESLKERGVDVAGLGAEWNQFTKRLSSGNSTSPVVLTNYLDTQYYGEIGIGTPPQTFKVVFDTGSANLWVPSTRCSPLYTACEIHCLYDSSESSSYMENGTTFTIRYGSGKVKGFLSQDMVTVGGITVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVGGVTPVFDHILSQGVLKEEVFSVYYSRNSHLLGGEVVLGGSDPQYYQGNFHYVSISKTGSWQIKMKGVSVRSATLVCEEGCMVVVDTGASYISGPTSSLRLLMDTLGAQELSTNEYVVNCNQVPTLPDISFHLGGRAYTLTSKDYVLQDPYGNEDLCTLALHGLDVPPPTGPVWVLGASFIRKFYTEFDRHNNRIGFALAR
The following text describes a protein:
Function:
Calcium-regulated protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Can promote the assembly of monomers into filaments (nucleation) as well as sever existing filaments.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSGLIKAKTYDWKDSNLALFGSSVEKSIKKESAMTETAWKNAGSKVGIKIWRIVKFKVTDWPEKEYGKFYSGDSYIILNTYKPNPSSNELAHDLHFWIGSQSSQDEYGTAAYKTVELDTYLDDVPVQHREVEGYESDLFKSYFKQGITLLAGGAETGFNHVKPTEYKPRLLHFHGNKQNVTLNEVPLNAGRLKSEDVFILDLGLVVYQWNGSDSNKDERFKALQYLQLLKSERGKCQCETLEDSDTPKTHEFYKHLNQPDEPDHIKPYQATEKTLHKVSDESGHLKQTEVKKGNIHLSDLKSQDVFIVDTGVSCFVWVGKQASHEEKQNGLGYAHSYLMKTNHPLVPIHVVKEGQQSKEFSLAVAA
The following text describes a protein:
Function:
Intake of glucose and galactose.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKFSFPFSGKSKQFTTQPALFSAIVILFFIWGFITLLNDLLIPLLRERLHLSYGQAMLVQFSFFFTYFLMSLPMAFLLNKLKYQKGIIVGLFIIALGCLIFIPADLTLIYRVFLFGLFILASGIVMLQVSANPLITLLGPTKTSSARLTLAQGINSLGYVIAPLIVGRFIVATNLYVPYIIIALVLMAVALFISQFNFHRVDDPLDKEEKDEIIDFALWKHLPFTLGLVGIFFYVGAEVSAGSLIVNYLHLPQIANFSLSHAAAYLSIYWGGAMIGRLIGSYVLTKINASKVLAVCAVANLLLLCGVILMTGGAAMWSLLLLGVFNSIMFPTLFALAIAGLPNESIKNKASGFLIMAIVGGAIIPELQGLLADYIGLQHSFILLLVSYVIITAYGVYINQTISHSHFF
The following text describes a protein:
Function:
Involved in cell specification during anther development. Required for the differentiation of primary parietal cells into secondary parietal cells in anthers. May serve as an extracellular ligand for the MSP1 receptor kinase to limit sporocyte number in ovules.
Sequence:
MRVSSASSTPPPPAFAAAAWAVVLLAMLRSDVALAAAASSNDDTGLSPLMPPPPLAAPVPAAVSPAPATPPAVLSPRKLLRPQGADVVGVGFVSGSGGGGGGDGVRTRRVDDGCAGADDIAIYQGRATPLPSGVPAYTVDVMNRCAGGGGGDEECAIAGIHVRCGWFSSVSLVDPRVFRRLGHDDCLLNDGRPLLAGETVSFEYTNSFPYKLSVSVATCVVDPAAP
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MKNKQHQEGKLKNHPFRHLIYGPTIGENSFNKFLQLTQRGLVYAKKCLKGPSDKFIKSKMVQLPECVIVKPKTLLLDLDETLIHSCSLRENPQVTVTAFGDYGEEAKIHFNIRPFCAWFLQQMSQLYTIYVFTASSSAYANAIVNYLDPKRQWILGILSRGNCMETKNGFFIKDLRIVGNKQLKDMVIVDNLAHSFGFQIENGIPILEWHNDQNDQELKYLATYLMEAADQEDIRVFNTQRLKLDQLIEYSLE
The following text describes a protein:
Function:
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MFAAKIAMFDSKESDFCGGNRNALLHEETTEWVKLNISLREHGLIPISFLYQQNNHAHEHDETNKYKDHILITLETLQNVRKAIQVLMKDSNRRQDLVQDMITTNNKLREELRRQTIKSKESDAKVNELMLTLNPTNANTATSAATVAAATTTAAATPTSATDMYKSKYEKLKKLKQELAHKCEAYENEIKALKDRITLFEKEDVKKEAKAKELYEKFKGRPGKIRFDDELLTVIDDYERQMRQLKRDIIKKDTFDIYHVSINEHTTNVRELIRSYERKIQEYLKRNKDLKNEIESLKTDLHTKEYRITVTNVASAENKPICSSSSTLSLVSSRYQQQQYQQRIPSSSSSSLSSLSPPQLHHPHHLLSTRLTDLKRQPASLCHKFLELTCSLLGVCDLLDIEPAILKLNKNSSTFNQLDSFVRDVHQMTSRYNLPRPRNKNCACNINNNNKNNNNNNNSTNNNNYAVCTDRHCLLLTLEHWVNQIKHLKNLQGSIKNLSEKMFPWRPISGDDDDDRVCGTLELVNMVDELVADGCHNRVLDASAASKDELVGIVRQFQILFEVPQVSGMYTRMSHLYRRLNENYNVMNNIKDVLGLDKSSNSRVVIDVVNKLVEMNVKTTEQHHQVQLQAQKSREAFDEEKEKLLQRLGEQEEFCSVFHETMQIIMQLLGVASVIQVVPSIERLLEASRD
The following text describes a protein:
Function:
Segment polarity transcription factor that provides positional cues for the development of head and thoracic segments. Forms a protein concentration gradient that patterns the anterior-posterior axis during embryogenesis and promotes the expression of anterior gap genes, such as hunchback (hb), ocelliless (oc), and buttonhead (btd). Binds to regulatory DNA sequences containing a 5'-TAATCC-3' sequence motif. Also binds RNA. Interacts with Bin1 to repress transcription of bicoid target genes in the anterior tip of the embryo; a process known as retraction.
Subcellular Localization:
Nucleus.
Sequence:
MAQPPPDQNFYHHPLPHTHTHPHPHSHPHPHSHPHPHHQHPQLQLPPQFRNPFDLLFDERTGAINYNYIRPYLPNQMPKPDVFPSEELPDSLVMRRPRRTRTTFTSSQIAELEQHFLQGRYLTAPRLADLSAKLALGTAQVKIWFKNRRRRHKIQSDQHKDQSYEGMPLSPGMKQSDGDPPSLQTLSLGGGATPNALTPSPTPSTPTAHMTEHYSESFNAYYNYNGGHNHAQANRHMHMQYPSGGGPGPGSTNVNGGQFFQQQQVHNHQQQLHHQGNHVPHQMQQQQQQAQQQQYHHFDFQQKQASACRVLVKDEPEADYNFNSSYYMRSGMSGATASASAVARGAASPGSEVYEPLTPKNDESPSLCGIGIGGPCAIAVGETEAADDMDDGTSKKTTLQILEPLKGLDKSCDDGSSDDMSTGIRALAGTGNRGAAFAKFGKPSPPQGPQPPLGMGGVAMGESNQYQCTMDTIMQAYNPHRNAAGNSQFAYCFN
The following text describes a protein:
Function:
Minor capsid protein essential for stable capsid assembly of complete particles.
Subcellular Localization:
Virion. Note=The capsid contains 60 copies of P30.
Sequence:
MALINPQFPYAGPVPIPGPAPTETMPLLNYRVEGRIAGIQQARQFMPFLQGPHRAVAEQTYHAIGTGIQMGQTFNQPLINTQEG
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MHRSSGHAEVASHMAGLEEPTTETFRGASETSSSWRVLFKLFKVKMNTGSKEVLSLDVQAPEVREELLRVKMKTESQLQMQESRLKRNNPLAREIFRRRFRQLCYQETPGPREALTRLRELCHQWLRPHVSTKEQILELLVLEQFLSILPKELQGWVREHCPESGEEAVTLLEDLERELDEPQHEMVAHRRGQEDLVKETVPLGEQTSLSLESEPKEPQLLCDPAQEPRSIGEADEMTKTEDRELVLRKDCPKVVEPHGKIFYGRIWEVSHQNHQRGEVGEHKGRIEGHWGKPLGEGQHKCDECGKSFAQSSGLIRHQRIHTGERPYECNECGKTFSRSSGLFNHRGIHNIQKRYHCKECGKAFSQSAGLIQHQRIHKGEKPHQCSQCGKSYSRRSFLIEHQRSHTGERPHQCNECGKSFNRHCNLIRHQKIHMVAELV
The following text describes a protein:
Function:
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MVYISNGHVLNGQNRSLWSLSFIKDFFWGILDFIIMFFKSMIHPNVKRGCRNSSSDSKYDDGRGPPGYPRRGMGRINHSNGPSPPPMAGGGGR
The following text describes a protein:
Function:
Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Note=Localizes in a nonuniform, punctate manner in competent cells, unlike some other competence proteins is not localized to the cell poles.
Sequence:
MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTETENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQVNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGVGPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK
The following text describes a protein:
Function:
Probable transcriptional regulator involved in developmental processes.
Subcellular Localization:
Nucleus.
Sequence:
MAAFLSAGLGILAPSETYPLPTTSSGWEPRLGSPFPSGPCTSSTGAQAVAEPTGQGPKNPRVSRVTVQLEMKPLWEEFNQLGTEMIVTKAGRRMFPPFQVKILGMDSLADYALLMDFIPLDDKRYRYAFHSSAWLVAGKADPATPGRVHFHPDSPAKGAQWMRQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVFVDPRKDSERYAQENFKSFIFTETQFTAVTAYQNHRITQLKIASNPFAKGFRESDLDSWPVAPRPLLSVPARSHSSLSPCVLKGATDREKDPNKASASTSKTPAWLHHQLLPPPEVLLAPATYRPVTYQSLYSGAPSHLGIPRTRPAPYPLPNIRADRDQGGLPLPAGLGLLSPTVVCLGPGQDSQ
The following text describes a protein:
Function:
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MYLGTESQPQSPMGLGLQVSWLFNPTRSEITSLDSGNIDDILNNADVALVNFYADWCRFSQMLHPIFEEASNVIKEEYPDKNQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVTAIADYIRQQKSNPIREVQDLEEINTVDRSRRNIIGYFEQKDSDNYRTFERVANILHDDCVFLSAFGAISKAERFSGDNIIYKPPGENAPDMVYLGSLTNFDLIYAWTQDKCVPLVREITFENGEELTEEGLPFLILFHMKDDLESLEKFQQEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPTDCPVIAIDSFRHMYVFPDFNDLSVPGKLKQFVLDLHSGKLHREFHHGPDPTDVAPGQPMQDVASSPPESSFQKLAPSEHRYTLLREKDEL
The following text describes a protein:
Function:
Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). Provides the major source of formate for the PurT-dependent synthesis of 5'-phosphoribosyl-N-formylglycinamide (FGAR) during aerobic growth. Has a role in regulating the one-carbon pool.
Sequence:
MHSLQRKVLRTICPDQKGLIARITNICYKHELNIVQNNEFVDHRTGRFFMRTELEGIFNDSTLLADLDSALPEGSVRELNPAGRRRIVILVTKEAHCLGDLLMKANYGGLDVEIAAVIGNHDTLRSLVERFDIPFELVSHEGLTRNEHDQKMADAIDAYQPDYVVLAKYMRVLTPEFVARFPNKIINIHHSFLPAFIGARPYHQAYERGVKIIGATAHYVNDNLDEGPIIMQDVIHVDHTYTAEDMMRAGRDVEKNVLSRALYKVLAQRVFVYGNRTIIL
The following text describes a protein:
Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MPSRAEDLIAKAEKKASSSVGWFGSSSSKWEEAADLFSQAAIAFKIDNKWQESGQAYEREAACRLRLNENNDAMNAFHNAAKSYKKSNPEAAVTALHQAIKLLIESGLFRQAADREKEIANIYAQDGIDPAKARDSFVRAGDWYKQEDANATANQCYQQAAEISADLGDFQKSMELYQTVADWSLTSALTKYSVKEYWLRAALCSMAMGDLVTTHKLLTEFAQKDLTFPSTREAKFAKDLMDACEEADLEKFTGTVYQYDQVTKLDNWKTGVLLKIKKALEEDEGGLT
The following text describes a protein:
Function:
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
Subcellular Localization:
Cytoplasm.
Sequence:
MASLYFVTGTDTEVGKTYCTAKTVERMRECGQRVGVYKPVASGCELRADGQRYSVDAATLWQAAGRPKNIDAVCPQRFLAALSPPQSAAREGVKVDTRQLRDGLAIWCDGDFDVVMIEGAGGLFSPISDDWLNVDLAIEMKRWSDQNGHSFELLLVAPDRLGVLHHVISTSRAAESAGIPIAGLILNRMDDHADESTQTNAEDLRRWCGIPMVASVRQPSGPLVVFSGPNGRNASGETSRETAGGVNFLNQTTIRR
The following text describes a protein:
Function:
Catalyzes the covalent attachment of ubiquitin to other proteins.
Sequence:
MYSKAYILLEREFRELKRDTRKDITAYPVSDDMMNWKAEIEGLRNSVCEGLVFYLTLEFSQEYNSVPPNVKFTTIPFHPNVDPYTGKPSIDFLDKPGKWNTNYTVLSILLDLQMLLSYPVLKNPVNLEAAQLLIRNASTYKMVIQELLPPALPKRESSLVIPEKPQDRVRVIKTISFNDYYKTWSQIATTKVAEHSRNPFVGDPHFMGQYYKWKQQDRQNQVQWESKFALSKWQTARKKIMAQEKSNHYNQVIGIYPSPSELSFEYEIEEEEEEEEEEEEEEEEEEEEEEKEEEEEEPRIYQIPQEWPEEHDSKESWEEEADHLVSWTNGLDEESLNYEYFDNVKNYENLGN
The following text describes a protein:
Function:
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
Sequence:
MQRIRKGDKVVVITGKNKGGSGIVLKVLTKQNKAIVEGINKVTVHKKEQVNKRSKQTNPTTKEAPLPLNKLALFDQKAKQQTIGKIKYQIDPKTKQKTRVFKKTNNAI
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MYLRMHCPHLNTGHTRFRAQSVCKSEAHQASLKRTLQWGWIPSIWLERISQIVCSETSGNSGHYHRTYYSNRRISGKVAAEFPLGVDGVNTSLRQVTKWNSSESPWLFKLWQQLLGLVNARKCCWLREYAVVAMTVIVVQGITSHDISHALPSTCPSLLEPKSVMEFPISTWTKSDSIVFCGARLDSYRCNSKVFTMRKTSLLKSVVGPGMRVYTASNLKRGALLRRQARGRGFEGLVSSIGGVLLATNASSIVLQSSPLAVVTGSLTSPLASIVNAGSHVDVNVLRASFTSSLNLISLCLFVVWMQRSGQLPAETPVVLSQVAFRVLIPCFLMTKVAITLASQPAANLLFLPLVAIAQVLTGASLGRLACRFVYPAPASASSPNFGNTAPITSVPPATIISERGSSAITQVATSNNVISFQENTEQYMAAKKEAIVTAACAFGNSFTLPLIFMTGVLAAEEASKVAGYLALFMVGWSPALWIVGYSLIATGDEESDSRGSVPKNRFSLNAILEEIKRIMNPPLYGVLVGMLVGGTPLSHLFLSEANTSAITMKSTGAFTVLCTFTSGILRPIFDAAALLGTATLAVQTIVLASSLATSIPSLSTASDAKISSPRVEAVEHLPDTGNHSIIKAVSFSTDLETVLDSRAFWIISSVRLVAMPIIMVVSTVILQSARILPADPVYNLLLMAQSAMPSAQNLVLLSQLRTSTRRLSGVLASLLLRQRMNFEVCFHFLIILRPEGYEENCSIGHSNVIPCNQLNAIT
The following text describes a protein:
Function:
Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Sequence:
MFKLSKLFYSFKHSSRSNIQHNLSSFKKKRRQELLYNIGLYGAAFGCAFGAVPFYRLWCEHFGLEGDLDKKDYSMKGKKLDVFRKYHIEFGAETDPEANWEFLPVQQNVTVHAGETALVFYRAYNRNDKAVVGFATYQIFPEDAGLYFAKIQCFCFNQQLLNPKEELQLPIYFYFEPEINEDPLLKKCENIKVMYRFYKAKNQELAQLAENEYKTVKKNKMILQKLRDAKKTGAVSEGDLNKIKSTKFTDKEIEDFDEWAYDNPLEAAEAQKEEESKN
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Plays a major role in negative regulation of the heat shock transcription factor (HSF).
Miscellaneous:
MISCELLANEOUS: Present with 3230 molecules/cell in log phase SD medium.
Sequence:
MIQDPLVYLDISIDKKPIGRIVCKLFREKAPKTTENFYKLCAGDVKSPLKDQQYLSYKGNGFHRVVKNFMIQAGDIVFGTQKDSSSSSVGKGGCSIYADKEEVKTDDESFCYGNFEDENLGEFVEPFTLGMANLGSPNTNNSQFFITTYAAPHLNGKHSIFGQVVHGKSVVRTIENCRVDSDGVPESDVRISDCGVWEKTMGVPLYNASNDQIGGDVYEEYPDDDTHFGDDDFGKALEAANIIKESGTLLFKKKDYSNAFFKYRKSLNYINEYMPEPDVDKERNIQFINLKMKIYLNLSLVLFNLERYDDAIMYATYLLEMDNVPNRDQAKAYYRRGNSYLKKKRLDEALQDYIFCKEKNPDDEVIEQRIEYVNRLIEENKEKTRKNISKFFS
The following text describes a protein:
Function:
Required for slo-1 potassium ion channel clustering at presynaptic terminals and in egg-laying muscles; clustering of slo-1 mediates the intoxicating and sedatory effects of ethanol on worms. Required for slo-1 localization to dense bodies in body wall muscle cells. Maintains the localization of the dystrophin complex near muscle cell dense bodies via its interaction with complex member dyb-1 which is required for slo-1 localization in muscle while slo-1 localization in neurons is independent of the dystrophin complex.
Subcellular Localization:
Cytoplasm. Note=Localizes near dense bodies in muscle cells.
Domain:
The vinculin/alpha-catenin homology 1 (VH1) region plays a critical role in interacting with dyb-1 and mediates the localization of ctn-1 near dense bodies; The vinculin/alpha-catenin homology 2 (VH2) region may play a role in the precise localization of ctn-1 near dense bodies.
Sequence:
MAASSMSSLTSSYHTTAMPSSNSVVPPFDARNLEIKTKSIEQTLIPLVTQITTLVNYKESYMASGKPKSERAMRAALKIGSAVEAAIERFVCVGETIADENADIQPEMYDACTEARLAGASMANLSCACNDDPNSVVDKAVLVRASRQLLSSVTRVLLLADRVLVKQVLRAEDKIAFSLSRLESTRSFNDFVKVFAVFGGEMVELAHRSGDRQHDLKSEKRKAQMSIARTSLERLTMLLLTASKTYLRHPDCDSALQCRDGVFYQMKLSLELIAICVCDGILTTEKSRYIQDEPDMPIDIALQLTANAAIKQLTEMLEMIRMTVRVGAGVRERIVSALDALCQLTQDFTDSAYTPHHQREQILDFLEECRFEMTNLIQPDENEQLAASGLEVTVERLNRRLKDLSKQLQIVAMEQISEVLRANEDQVLLSSMKACAVSGDIDGVEKYMHKFREHADHMQEVCRLLHHISITDALHVHTGHVERNMRALAPLTILAGRTLCVHPSSRIARENLEVFCDTWGQAVNDLSRVAKESDVAANGRVAAEKQAYMSLPRPGKHGTTQKPSKPITLDVEDQQKMAKVGLEMKLLTSEVDAEAEKWDEYAENDIVKRAKAMSSMAYNMYLFTRGDGPLKTTHDLFTQAEFFAEQANQMYRTVREFSYEVPGSAEKSDLSAILERIPLHCQQLQVMVKSPTVGKTATFGKVDSVIQETKNLMNEIAKLVTASFVCATKYEIEFRGGSVNGRTGADGERTSRESTVWRRTPSIRRAAPPTSSHLSANNSSSIHI
The following text describes a protein:
Function:
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Subcellular Localization:
Secreted.
Sequence:
EGCSSQHWSYGLRPGGKRDAENLMDSFQEIVKEVGQLAETQHFECTMHQPRSPLQDLKGALESLIEE