lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Its activation by VPS15 may lead to the phosphorylation of phosphatidylinositol in the sorting compartment membrane. Finally, it might also be involved in ethanol tolerance and cell wall integrity.
Miscellaneous:
MISCELLANEOUS: Present with 1080 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Sequence:
MSLNNITFCVSQDLDVPLKVKIKSLEGHKPLLKPSQKILNPELMLIGSNVFPSSDLIVSLQVFDKERNRNLTLPIYTPYIPFRNSRTWDYWLTLPIRIKQLTFSSHLRIILWEYNGSKQIPFFNLETSIFNLKDCTLKRGFESLKFRYDVIDHCEVVTDNKDQENLNKYFQGEFTRLPWLDEITISKLRKQRENRTWPQGTFVLNLEFPMLELPVVFIEREIMNTQMNIPTLKNNPGLSTDLREPNRNDPQIKISLGDKYHSTLKFYDPDQPNNDPIEEKYRRLERASKNANLDKQVKPDIKKRDYLNKIINYPPGTKLTAHEKGSIWKYRYYLMNNKKALTKLLQSTNLREESERVEVLELMDSWAEIDIDDALELLGSTFKNLSVRSYAVNRLKKASDKELELYLLQLVEAVCFENLSTFSDKSNSEFTIVDAVSSQKLSGDSMLLSTSHANQKLLKSISSESETSGTESLPIVISPLAEFLIRRALVNPRLGSFFYWYLKSESEDKPYLDQILSSFWSRLDKKSRNILNDQVRLINVLRECCETIKRLKDTTAKKMELLVHLLETKVRPLVKVRPIALPLDPDVLICDVCPETSKVFKSSLSPLKITFKTTLNQPYHLMFKVGDDLRQDQLVVQIISLMNELLKNENVDLKLTPYKILATGPQEGAIEFIPNDTLASILSKYHGILGYLKLHYPDENATLGVQGWVLDNFVKSCAGYCVITYILGVGDRHLDNLLVTPDGHFFHADFGYILGQDPKPFPPLMKLPPQIIEAFGGAESSNYDKFRSYCFVAYSILRRNAGLILNLFELMKTSNIPDIRIDPNGAILRVRERFNLNMSEEDATVHFQNLINDSVNALLPIVIDHLHNLAQYWRT
The following text describes a protein:
Function:
Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
Sequence:
MAKVYISLGTNLGDKEQNLRTAVQKIEEQVGKVISLSAFYITAPWGFDSEHSFLNAAACVETELSPLEVLQKTQEIERELGRTHKSVGGVYSDRLIDIDLLLYDDLILSVTSPSGAALNLPHPLMAERDFVMRPLTEIAPELVHPVLGKAMKVLLAQIEK
The following text describes a protein:
Function:
Multicopper oxidase; part of the gene cluster that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment and a structural component of the conidial wall. The first step of the pathway is the production of the heptaketide naphtopyrone YWA1 by the polyketide synthase alb1 though condensation of acetyl-CoA with malonyl-CoA. The naphtopyrone YWA1 is then converted to the pentaketide 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN) by the heptaketide hydrolyase ayg1 though chain-length shortening. 1,3,6,8-THN is substrate of the hydroxynaphthalene reductase arp2 to yield scytalone. The scytalone dehydratase arp1 then reduces scytalone to 1,3,8-THN. 1,3,8-THN is also substrate of the hydroxynaphthalene reductase arp2 to yield vermelone. Vermelone is further converted by the multicopper oxidase abr1 to 1,8-DHN. Finally the laccase abr2 transforms 1,8-DHN to DHN-melanin. DHN-melanin biosynthesis appears to be initiated in endosomes where early enzymes (abl1, ayg1, arp1 and arp2) localize, with exocytosis leading to melanin deposition on the cell surface where late enzymes (abr1 and abr2) localize. DHN-melanin is an important structural component of the outer cell wall and is required for the presence of conidial surface hydrophobins. DHN-melanin also plays a crucial role in fungal virulence, including a protective role against the host's immune defenses. DHN-melanin also protects conidia against amoeba predation.
Subcellular Localization:
Secreted. Cell surface. Note=Localized at the surface of stalks and conidiophores, but not in young hyphae.
Sequence:
MFHSRALLLSWLVGFTAAKDIHLDWNITWVWAAPDGFGRPMIGINNEWPCPIVNADLGDRLIVDVHNGLGNQSTGIHWHGFHQYMTGTMDGSNQVTQCALPPGSSMRYEFDVNQTGTYWYHSHEMGQYPDGLRGPFIVRDPSPPFAYDDEFTLTLTDHYHEQMSVLLQQYEADSVGAQAGVNEPLPAAALINEGFDTTTLRVEPNKTYLIHLVCVGNWPGHVIVFDDHEISVVEVDGTWVDAYPARDKKIRLATGQRMSILLKTKDNTDRNYAIWDSMDVNMMFFYQNRAIPEGFNPNTTAWLVYDEAKELPPAPDVHELDPNNDFVDDLVFVPASHEPLLEKVDRQIIFDTGVTQRDGRSVYTINGQTYVDPEEPTLYTALAASPENASNASLYGQVNPFVVQYGEVVEIIINNHHGNLHPWHMHGHQFQVLQRTIPEGGYFDGYFANISSTPVKRDTIMVQNHGHAVLRFRANNPGVWLIHCHIEWHVTKGLTGTLIEAPAQMHKISVPLDHQRICPSYGTPPGGTPSSPPHDAPRPDGASGSPQYPPKPWGEPDASAPEQDDSQPGGTPDSPEDFPQPWGEPEESPQEPPQPWSPSNNAQPPANTYAPEYPSGYVPVAPGPVIIDSELHYGGKSSHVECSGVNAGHTQDTTTGGDGCANAS
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSKKWKVENLVEEASDTEESDVEQDEERPLKSSDDDEDELSGLDIPEAKLPVLRSIVSKGKTVDHDQQRSFQGSERGEEAEKLAIREELSALTFEELQKLKEKIGSKKFNQTLIGVKKKPQVRTDFKRANPNRPREISSKSRRIEPKVAIQVPKVFRSDPRFDNLCGEFHEKKFYKNYDFVNKMKEDEVKKLKEELREETNPRRTEKIKYLIQRMENQIRSEKMRKLEEEKQEEEKQITIDALKEGKSPYFATKAARKERNLKEKFDSLKEEGRLNQYMAKKRKHNAQRDRRHMPSEDY
The following text describes a protein:
Function:
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization; Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
Subcellular Localization:
Cell membrane, sarcolemma. Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Postsynaptic cell membrane. Secreted, extracellular space.
Sequence:
MCSHITVGPHSCNSVRVFRGIPDKEVDAGTVFFHPIPPVAFHGPVKDYEVSLAGTIDKLPRWLDYNPQTQSLQGLAVSEERGDYTIAVTAVGHCRQEPSPSTHFHLHVLNGTHSLKARSLRRLDWRNKHTKSSQGCPAGETVTYSAIILQADVFSLSAGRRLLLVSTMGEYLRLDPFSLKLRSFRSPSELQLENSTLLTEDTGIGDSPDTHAAVEVYWPVGCGDFQMVSELVRVLRYSKDSGHLSHLLGLHLTGWRVFTWGGGGSQHRRRERRQLINTPTPVMTPVAPTYVSATLPMKPSYSYIVLTPAVEVAAPSPTEGVSILTSPTEVPTFYTATRVPAVPETPRTLPRTLSTLNLVPTSLNQQQITSESSVTPPIRIPVSSQSNTHFTRFSLPLSAVPANYTLLNPGVSNIPNISPFVLRPIKPLIATIGLLFEFSIPADTFSDPEDGTADNLTMKIRPSDGSPSGPESWLTLDHKQRLLSGYPLDSDMLYSPQELLLIARDSGGLSAELPFTIELRHPLSEPCHTYTIRTMNSFHSFVKDRRKIELFLNKMAKYFNDTGSSHISVSTLQPGSTVVSWHNVTLCQEDKKAQSLCPKHNIQGLLSAMQTLEGDVEPSFAQAMLPEFR
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MAEERAELFLDESRFAQSLRLQALRVPKRLCGQVSKLLAGYVIDKPRVKHIVNDPADAESRLVIFSESVKDPSLHEIPDEKLNALKDLVDLDVTPHEILLSYEHWSADHVLREILPKTCEVPSSFETIGHIAHLNLRDEHLPYKKLIGKVLLDKNPKLKTVLNKVGTIKNEFRVPSFELLAGEDNMVTEVKQYGAIFHLNYGLVYWNSRLEHEHKRLVSEFQPGQVICDMFAGVGPFAIPAAQKGCLVYANDLNPASVEYLLKNADVNKVGNRIVAYNMDAREFMKELVNPATAMAHALNKADEGNTSRDGVSDRQDSGKKSLRLSLSSMHYTLKAKVKRKQTNAVHSDVVEAKPWEHFDHVVMNLPASALTFLDTFRGLLSKDSWKGSMPCVHCYCFLRAKQTTADIMNVRNSCLLFFISGLIFSRLLKTLSEDLYLEHRFGQCVWLHQTR
The following text describes a protein:
Function:
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells.
Subcellular Localization:
Nucleus.
Sequence:
MDSLEEPQKKVFKARKTMRVSDRQQLEAVYKVKEELLKTDVKLLNGNHENGDLDPTSPLENMDYIKDKEEVNGIEEICFDPEGSKAEWKETPCILSVNVKNKQDDDLNCEPLSPHNITPEPVSKLPAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPTSSEPSSSDAASGDATSGDAPSGDVSPGDATSGDATADDLSSGDPTSSDPIPGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGDLSSSELASDDLATGELASDELTSESTFDRTFEPKSVPVCEPVPEIDNIEPSSNKDDDFLEKNGADEKLEQIQSKDSLDEKNKADNNIDANEETLETDDTTICSDRPPENEKKVEEDIITELALGEDAISSSMEIDQGEKNEDETSADLVETINENVIEDNKSENILENTDSMETDEIIPILEKLAPSEDELTCFSKTSLLPIDETNPDLEEKMESSFGSPSKQESSESLPKEAFLVLSDEEDISGEKDESEVISQNETCSPAEVESNEKDNKPEEEEQVIHEDDERPSEKNEFSRRKRSKSEDMDNVQSKRRRYMEEEYEAEFQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRVEKIECNKRHKTVLTELQAKIARLTKRFEAAKEDLKKRHEHPPNPPVSPGKTVNDVNSNNNMSYRNAGTVRQMLESKRNVSESAPPSFQTPVNTVSSTNLVTPPAVVSSQPKLQTPVTSGSLTATSVLPAPNTATVVATTQVPSGNPQPTISLQPLPVILHVPVAVSSQPQLLQSHPGTLVTNQPSGNVEFISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRGPIQMKIPISAFSTSSAAEQNSNTTPRIENQTNKTIDASVSKKAADSTSQCGKATGSDSSGVIDLTMDDEESGASQDPKKLNHTPVSTMSSSQPVSRPLQPIQPAPPLQPSGVPTSGPSQTTIHLLPTAPTTVNVTHRPVTQVTTRLPVPRAPANHQVVYTTLPAPPAQAPLRGTVMQAPAVRQVNPQNSVTVRVPQTTTYVVNNGLTLGSTGPQLTVHHRPPQVHTEPPRPVHPAPLPEAPQPQRLPPEAASTSLPQKPHLKLARVQSQNGIVLSWSVLEVDRSCATVDSYHLYAYHEEPSATVPSQWKKIGEVKALPLPMACTLTQFVSGSKYYFAVRAKDIYGRFGPFCDPQSTDVISSTQSS
The following text describes a protein:
Function:
Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Sequence:
MAAKSARKGPTKAKKNLLDSLGVESVDYKDTATLRVFISDRGKIRSRGVTGLTVQQQRQVAQAIKNAREMALLPYPGQDRQRRAALCP
The following text describes a protein:
Function:
Uptake of glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MVTWTQMYMPMGGLGLSALVALIPIIFFFVALAVLRLKGHVAGAITLILSILIAIFAFKMPIDMAFAAAGYGFIYGLWPIAWIIVAAVFLYKLTVASGQFDIIRSSVISITDDQRLQVLLIGFSFGALLEGAAGFGAPVAITGALLVGLGFKPLYAAGLCLIANTAPVAFGALGVPILVAGQVTGIDPFHIGAMAGRQLPFLSVLVPFWLVAMMDGWKGVKETWPAALVAGGSFAVTQFFTSNYIGPELPDITSALVSIVSLALFLKVWRPKNTETAISMGQSAGAMVVNKPSSGGPVPSEYSLGQIIRAWSPFLILTVLVTIWTMKPFKALFAPGGAFYSLVINFQIPHLHQQVLKAAPIVAQPTPMDAVFKFDPLSAGGTAIFIAAIISIFILGVGIKKGIGVFAETLISLKWPILSIGMVLAFAFVTNYSGMSTTLALVLAGTGVMFPFFSPFLGWLGVFLTGSDTSSNALFGSLQSTTAQQINVSDTLLVAANTSGGVTGKMISPQSIAVACAATGMVGRESELFRYTVKHSLIFASVIGIITLLQAYVFTGMLVS
The following text describes a protein:
Function:
Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.
Sequence:
MSLSKHVKPEQLLQSVKEHGHKTVHGDHHENISTPYSSRYASREIPKFKLPSKGIEPDTAYQLIHDILDLDGRENANLASFVHTWAPKQAIQLCVENLGKNLIDQDEYPQTQILHTRCISMLAHLWHAHNSSNAIGTATTGSSEAIQLGGLAMKKIWQAKRKAAGKSIHEPGPNIVMGANAQVALEKFARYFDVEMRLVPVSEKTNYCLDPIKAMEYVDENTIGVFVILGSTYTGHFEPVKPLSDLLDAYEAKTGISVPIHVDGASGAFIAPFVYPDLPWDFRLPRVVSINTSGHKFGLTYVGCGWVVWRDQAHLPKELIFELHYLGSVEYSFSLNFSRPAHPIIHQYYNFVQLGFEGYRAIGLDDLANARLLSRALERSRYYKVLSDIHRKKADMQKPRDQVFGESGLKFEEYVMGLPVVAFCWTDEFKKKHPHLKQSWVQTLLRAHAWIVPNYELPPDLEDLQILRVVVRESMSPELVDRLFCSIIEITECLIKEGGPGNFLDAVPKGKSHEHAFGNHQREDATKPVGYARPC
The following text describes a protein:
Function:
Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.
Subcellular Localization:
Cytoplasm, nucleoid.
Sequence:
MSEHNRRLVEKAGIDVEKLLDMLLRAAAAEFTTYYYYTVMRNHATGLEGETIKEIVEDARLEDRNHFEALVPRIYELGGELPRDIVNFSKMAWCCDAYLPEEPTIENVLKVLLEAERCAVGVYTEICNYTFDKDPRTYDLALAILHEEIEHEAWFEELLTGKPSGHFRRSKPGESPYVSKFLR
The following text describes a protein:
Function:
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell projection, ruffle. Note=Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia.
Sequence:
MAAPQDLDIAVWLATVHLEQYADTFRRHGLATAGAARGLGHEELKQLGISATGHRKRILRLLQTGTEEGSLDPKSDSAMEPSPSPAPQAQPPKPVPKPRTVFGGLSGPATTQRPGLSPALGGPGVSRSPEPSPRPPPLPTSSSEQSSALNTVEMMPNSIYFGLDSRGRAQAAQDKAPDSSQISAPTPALRPTTGTVHIMDPGCLYYGVQPVGTPGAPDRRESRGVCQGRAEHRLSRQDLEAREDAGYASLELPGDSTLLSPTLETEETSDDLISPYASFSFTADRLTPLLSGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDMWCSTLQSCLKEQRLLGHPRPPQPPRPLRTGMLELRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHPQYPDHSQLLQALCAAVARPNLLKNMTQLLCVEAFEGEEPWFPPAPDGSCPGLLPSDPSPGVYNEVVVRATYSGFLYCSPVSNKAGPSPPRRGRDAPPRLWCVLGAALEMFASENSPEPLSLIQPQDIVCLGVSPPPTDPGDRFPFSFELILAGGRIQHFGTDGADSLEAWTSAVGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTAPAPGLWLSGFGLLRGDHLFLCSAPGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRLDFTAWNAAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVIGCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTDGRGEHEVRVLQELIDGYISVFDIDSDQVAQIDLEVSLITTWKDVQLSQAGDLIMEVYIEQQLPDNCVTLKVSPTLTAEELTNQVLEMRGTAAGMDLWVTFEIREHGELERPLHPKEKVLEQALQWCQLPEPCSASLLLKKVPLAQAGCLFTGIRRESPRVGLLRCREEPPRLLGSRFQERFFLLRGRCLLLLKEKKSSKPEREWPLEGAKVYLGIRKKLKPPTPWGFTLILEKMHLYLSCTDEDEMWDWTTSILKAQHDDQQPVVLRRHSSSDLARQKFGTMPLLPIRGDDSGATLLSANQTLRRLHNRRTLSMFFPMKSSQGSVEEQEELEEPVYEEPVYEEVGAFPELIQDTSTSFSTTREWTVKPENPLTSQKSLDQPFLSKSSTLGQEERPPEPPPGPPSKSSPQARGSLEEQLLQELSSLILRKGETTAGLGSPSQPSSPQSPSPTGLPTQTPGFPTQPPCTSSPPSSQPLT
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAVSSPLQLSVVIHPVVVLTICDSYERRNEDIEKIHGTLLGKVEKERIEIRNCFIDDNPTASGKKKFNLEEFQRLFDLHQRVYPNEVIVGRFSTGDQIDDTALAMQALFSRVIESSYVAFPIHLLVDTNLTDSHMGIQASVYHRYGVPGNDNGSIFTPIRYAMGYYPEEMSASQLFQRNLAIGGIAPVHNDMQHVIATSTKIDELLDEVLKYVEDVTAGNTPFDSKIGRSLSDAIMAVPQIDQSVFKDMMNNSTQDLLMVTYLGSLVRTQLALAEKLNTIL
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MALLQSSGIRTAILIAVCGALSNRSAAHTSKHPLLATEIKPLCGLSGQLKTTALYVKQKLNQQATYTDSITQLARKLVVYSKTRTDDDDARIALALATEAQKLQEAATRKLLTMASKGTVLAVQAGLAAGIIDDFIALVAGVTPGGTTNNNCIINKDALSGTATFTTIAEQLPGCETTEIVTTEPPAKPILRGQDFTGFNNIKTLGNAATYSQTCCKLLQHASDADLTGAGYTGNKLLVAGGAIHVTSNNIQIAKLTNLSSAADQSVFENTQKKLKDFDVHKADDPATTHVALYTAALTSEAVKAATDIKLQKKRRTNQEINADSALESKVKGIIGSDADSFKNTYLDKVNKETIKLPKEWELELSYNKLENLETDAQYETILLYLSKVSQNNREQACTAVRQEQKQQETDETCEKKGTEDNYKDGCKWDGEGDNKKCVKDLDYKPKQVEEKDDGIKEEKCAGKQQEDCKSMDCKWKGENYKYSSFLVDKKMALSMDTAFKGLVEFSNFKNLFSIL
The following text describes a protein:
Function:
SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.
Sequence:
MSLKILHTSDWHLGKVFKETTFELLPIQKQIMDEIVDITRKENPDIVLIAGDIFDTYNPSFEAEKIFYETLSRLSEQNCFVFALAGNHDSPDKLQISKPLIAGKHSIFIKSTAFDESKDIEFENENFKLALENSFLKLHLKNEGTVIALKCLPYLSEVRLGLAGDEYLKKVNELLSIEPQFSCDYFLLTSHLSIAGAQQSGSERIFQIGGIEYIPIDFLPKSAHYIALGHLHRHQKLRNATYSGSIYPFDLAEIEHKKGVSVWENGKPDFIEFNKIPKIRKIEFDSLEDAVKNAPEDEAYYYVLIKNPHAYTTASIDALLKAYRNRLVNWQFYTPDVPEEISIPELHSLNEEEMFIEFYRAKLNKKPSQDILSLFLKTLEEVKNATN
The following text describes a protein:
Function:
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Subcellular Localization:
Cytoplasm.
Sequence:
MSKQEVILCESLETSLGRAIERCPHDKLFILTDEHTQRLCLPSLKEVSFLKDAVEICIGAEDVHKTLETLASVWMALSQQGATRHSLLINLGGGMVTDLGGFAAATFKRGISYINIPTTLLAMVDASVGGKTGINFNGLKNEIGSFAPADSVLIETEFLRSLDAQNFFSGYAEMLKHGLISNTAHWVELLDFNTNNIDYAYLKNMVGRSVQVKEDIVEQDPFEHGIRKALNLGHTAGHAFESLALAENRPVLHGYAVAWGIVCELYLSHLKVGFPKDKMRQTIQFIKENYGSFAFDCKQYEQLYAFMQHDKKNTSGTVNFTLLKEIGDICINQTADKDTIFEMLDFYRECMGV
The following text describes a protein:
Function:
May act as a modulator of septin function during cytokinesis in the developing nervous system.
Subcellular Localization:
Cytoplasm, cell cortex. Cleavage furrow. Note=During mitosis, detected at the cell cortex in metaphase but is concentrated at the cleavage furrow at telophase. Colocalizes with pnut at the cell cortex.
Sequence:
MYRPNFYESTCLRCSETVYQVDRVGPLKDFTFFHSGCFKCVHCGTKLTLKTYFNNQHKQDDKEVYCSSHVPKSGPGHLDQTSVGIRQALNAPRTNKFVNEQIRGTRSEVDGGPLGGSRQSTPNGYGSREISSPSQNDSDYKYGRFDASALHIAHALKQTEIQKAYNKAREKPIDFYLAREEQAHLEMKHRKEEDDLYRKFASKRAEEDRKIQDEFQDEWERELQRLTHKFEKELATSRRSRDEANILTMRHEQQKEDLEKNMTLRRSKKKESITRKMLEHERYETAALVDRQSSEMLELISARRSEYMQSESIFLDDEFSEGAVPVEYPLNAPIPAPPAVSKFQIYTDPIEFEDVDRIAISVAQEDQKTFTDLVRQLVGRCTTDIEKARTIFRWITVKNLNAMHFDDDLRGDTPMGLLRGIKYGTESYHVLFKRLCSYAGLHCVVIKGYSKSAGYQPGVKFQDSRFRNSWNAVYVAGAWRFVQCNWGARHLVNAKEAPKQGRGKNDSLRYEYDDHYFLTDPREFIYEFYPLQEEWQLLKRPITLREFENLPFVRSLFFRYGLHFADEGYGAVVFTDDTGAATVRIAMPTDMQSCLIFHYNLKFYDSDEELSYDGVSLKRFVMQSVIGNIVAFRVHAPCSGAFLLDIFANAVTPQEYLTGEPMKFKSVCKFKICCEELQTVMVPLPDCASGEWGPTKATRLFGLIPITHQDPLIFAGRSLDLQFRMSRPLTDFMATLHKNGIEEKKLAKYVTHSTLDDIVTFIINFPEEGQYGLDIYTRELGGPQHHHHHNNNNSSSSSGEKHLLTHCCKYLINSSKRN
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEMNSPHEKAVQAIRYGHSCAMRLKRRLNHPMADGGPLSSYDLAKSIVESFSNAISILSAKPETEDDQFSDLSSRDSSPPPQGSPSKKRKIDSTNSSENWRDDSPDPIYYDGYLWRKYGQKSIKKSNHQRSYYRCSYNKDHNCEARKHEQKIKDNPPVYRTTYFGHHTCKTEHNLDAIFIAGQDPLDDFKSTQMIRFGKDQDQEKESRSNGFSLSVKHEEDIIKEQAIDQYREITSNDQDCQDVIEEYLSSPSGSYPPSSSSGSESADFNSDLLFDNPDSWDRYDQFYF
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSSVTTKKESDLSGEIEDFVALLKRGGKRPRSEEAARQTVGLLRRIVANGRWDNAGDLMELIRKEGKRMTAAQPSETTVGNMVRRVLKIIREEYGRLRGRSEENDQQESLHKLLTSGGLSEDFSTYYSPLRPNIIEAINELLIELEGTTDNIAMQALEHIHSNEVIMTIGYSRTVEAFLKEAARKRKFHVIVAECAPFCQGHEMAVRLSKYNIETTVMSDAAIFAVMSRVNKVIIGTKTILANGALIAVSGTHTLALAAKHHSTPLIVCAPMFKLTPQFLNEDDSFHKFVSPHEVLPFTEGEILSKVNVYCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDREL
The following text describes a protein:
Function:
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Sequence:
MSSAHFNRGPAYGLSAEVKNKLAQKYDHQQEQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKVNESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLANLPTTTTRTTTTTLPRVLGLPPSPREAGCCSWWAWPGLLTPSPCMAPPAPWHLPTGLVFVGSRLGNLWGGRGHLPGALRGPTWSWVFPTAPKGRTEQSYPAVPHSPQVGPPPDQKPPQAKPPEPRLAPPPTPFPQWEQTACPETQRTHAVWFAAGLWDVTVAFVTRALSFSTSLEHNK
The following text describes a protein:
Function:
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
Subcellular Localization:
Nucleus.
Sequence:
MSSGDQNRGGVADKALQLVLEMKRNPDVLPPYNTELVRQCYQKIDELFQKNAAVVEKIRAGLPHDSTLLQPRLAAMCHIRRCMMAYVNERKNRIRSFRWKYGGALPASVRNALCDAEIQFFNEYSSTLARFQSNLGEGGVNLLLHSAPPKSLFVQVRALEDYGEFETSDGTQVQLSKDSLHSLPRQDCEMLIRQGVLELVH
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLGQELIAARRPWGEAFRAPAFSKSPSVGEAIAKARWNTAYFRANYALVVAASSLLWHPGTLFALHALCTA
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MEAISDRLFNENANTIESGNDDPSLLTIILDLSMKGWYNIKEMISIQDITKSLLVFLNGHLSLNNSNQVAFLVSSTMGSKFLYPDLTMVGNPNVSEHSEHFPDMYRSFKMVDQSVLQRLNEYIEEIIKFETGNEKKGFNCLTGAISMALTYTNRMLTLDQSITTTTAAAMTASTLESTSNNNNTSGTSGSSSTSSSTSMKSRVLIVSANDDDDLRYIPLMNCIFAAQKMKVSIDVAKLGHNNSSYLQQASDATKGVYLHIEDPKGIIQVLSTAFFIEPNLRPYIILPTNSNVNYRASCFITGKSVDLGYVCSVCLCIMSQLPQSGKCPACDSEFDKKIIQDLNREPQVISKKKRKLENGSSTK
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC.
Sequence:
MAQSINITELNLPQLEMLKNQLDQEVEFLSTSIAQLKVVQTKYVEAKDCLNVFPLTLASQMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKDFFKRKIDFLTKQMEKIQPALQEKHAMKQAVVEMMSQKIQQLTALGATQATAKA