lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulator of pre-mRNA splicing (and, possibly, of other RNA processing events). Regulates its own expression at the level of RNA processing.
Subcellular Localization:
Nucleus speckle. Note=Speckled subnuclear compartment.
Domain:
RS domain directs localization of proteins to the speckled subnuclear compartment and the purpose of this localization is to allow colocalization and co-concentration of components of the splicing and splicing regulatory machinery to permit relatively high rates and/or efficiencies of reaction and interaction.
Sequence:
MLPYNVRNAGGGSVGGILRRTGQGSGTGSTILGNGNSPGALGAGKVSSSLENHRQPPLELLVFGYACKIFRDDEKAREMDHGKQLIPWMGDVNLKIDRYDVRGALCELAPHEAPPGGYGNRLEYLSAEEQRAEQLCEEERYLFLYNNEEELRLRQEEDLKRLQQETSGGCFSQVGFQYDGQSAASTSIGGSSTATSQLSPNSEESELPFVLPYTLMMAPPLDMQLPETMKQHAIIEKTARFIATQGAQMEILIKAKQANNTQFDFLTQGGHLQPYYRHLLAAIKAAKFPPAPQTPLDQQNTDKEAPSADDHSEEVAGGRRNPNQVVITVPTIKYKPSANCAYTQLISKIKGVPLQAVLQEDESSNPGNSQHSGGTASPALSCRSEGHNSQGGEFTPVLLQYNGSTFTHEEESSNREQQDDNDVNGGEPPQVELLKNTSALALAQNYSSESEEEEDQVQPEKEEEKKPEPVLTFPVPKDSLRHIIDKTATYVIKNGRQFEETLRTKSVDRFSFLLPANEYYPYYLYKVTGDVDAASKEEKTRKAAAVAAALMSKKGLSFGGAAAAVSGSNLDKAPVSFSIRARDDQCPLQHTLPQEASDEETSSNAAGVEHVRPGMPDSVQRAIKQVETQLLARTAGQKGNITASPSCSSPQKEQRQAEERVKDKLAQIAREKLNGMISREKQLQLERKRKALAFLNQIKGEGAIVGSAVPVVGPNPPESAAGAATADSGDESGDSVRSIPITYFGPDDDDEVGEQRPEMRLIGSTQKDEEDDDEEDGGDLEKYNLLNDDSTNTFTSKPVLPPTAAPPPAAVLLSDDDDVQLVATTSTRSSSSRHLKTHRRSRSRSKNVRSSDSSPSSRESSRRRRQKSSRLSREPSSNPPRKSQHSSTQRKKTPKKRRRSKSRSRSKSIRRSRSISILRNNRRSRSRSPSCRNAEQRRQQDRRRTPTKKSHKRHKRRRRSSSP
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB28 is required for shedding and phagocytosis of cone cell outer segments (OS) discs in the retina. Also participates in nuclear factor kappa-B p65/RELA nuclear transport in endothelial cells.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton, cilium basal body. Nucleus.
Sequence:
MSDSEEESQDRQIKIVVLGDGACGKTSLAMRFAQESFGKQYKQTVGLDFFLKRITLPGNLNVTLQVWDIGGQTIGGKMLDKYIYGTQGVLLVYDITNYQSFENLEDWLSMVKKVNEESETQPFVALVGNKIDLEHMRTVKADKHQRFCQENSLGSYFVSAKTGDSVFLCFQRAAAEILGIKLNKAEIEQSQRVVKADIVNYSQEPVTRMVNPPRSSMCTIQ
The following text describes a protein:
Function:
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MKTRARPRGPRAEAAAARLLLLAWALLQVAGASGTADVVVAYNLTWKSTNFKTILEWEPKPINHVYTVQISPRLGNWKSKCFYTTDTECDLTDEIVNDVHQTYQARVFSYPADATDYSGEPPFTNSPEFIPYIETKLGQPTIQSFKQVGTELNVIVQDARTLVKVNGTFLSLRDVFGKDLSYTLYYWKASSTGKKTAKTNTNEFLIDVDEGQNYCFSVQAGIPSRKANQKSPESPIECTSHEKGMFREMFLVIGIVVLVVIIFTIILSVSLYKCRKVRARQSGKESTPLNAA
The following text describes a protein:
Function:
Transcription factor involved in epidermis differentiation.
Subcellular Localization:
Nucleus.
Sequence:
METLQGRKPKKPHYIPRPPGKPFKYQCFQCPFTCNIKSHLFNHMKYNLCKNSISLVSQRMEQTGKASRASQHSPAFSHNSKELPLDAESTKPIENVKIEKAVTKEAREKPQSPIKEVSKDDTEPALEAKDKSEDMDIAQNKISSAFSPVARTCESEALSLSPHKDDQSTIPHFYQQIAPWVTSASSAHLLPPIPEYPPYMVPERSLPPLYAPYPHNQASTPAYQVTPRETQRPLVPSPLIPPNSSLLHPYHYRYGHSIFPSPPLPYSFYQHPELSIPLQRSRYLPLDVYSSRFYPREYGGHLVPLTHPESYSRLAEDRAVQEHNTGDKGIRESPLEGCDASGSPDRPSTADVTQRIPVGLRLASHGESHSGSQSHIISGSTKANDNLPKMPCGQNQEKMLQKTERYDSQTTISSRSSDISDKEEDEETEEEIGPLNLSKRDQATSNNMTHHHYPDRELHYDSESSQEEAPLNLCLRVQSSNQALPNTSETPEKETISNAEVSTTESPQDLEPCDQRQTAAFALCQLASSRDIINDTSVKQQDVTESQNTKCLPSPDNCSVKDSPNILNASMVALGQKRANNRPLRHTNKRAKVKEPSRPRRKRSQNC
The following text describes a protein:
Function:
Plays a role in the life span. May be involved in regulating the redox state of the cell and possesses anticarcinogenic properties.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type III membrane protein.
Sequence:
MVYIDHNGRVWEKRPWDWRRIVELFVGIWFAIKQLFLTFLAPFTGNNNQANPRRGNGWGGGGGWGGGGGGGGGGGGGRPGSGSGGLRPNRRIGRIQPTMSCNMPAGGGUG
The following text describes a protein:
Function:
Involved in maceration and soft-rotting of plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MAPPIAIYILFSLLFISHICVSSYVPSEISQPKRRQENFPSSTIPPPGSLVVRQTNAKQGDYNTISAAVNALKTLKGPQVIFIGPGTYHEQVHIKYKYPLRIQGYSSDPNSLTGNQVTVQVAVSAASHNGENAPSSAIWVQSPRFEMHNVNVINSFGTGTDTQAVALTAQGEKHVYKYCLFTSYQDTLLIKAASSYFYGCRVEGAVDFIFGSGSAWFEMADIVVKPPKHFATITAQRRAQGGNTMFVFNKSKVLPFSQDTQPNSVYFGRPWSPYSAVTFQSCYLSNIINPLGWIPWNESSDPRTQHVTYQEFNNYGPGSPTQKRQMSSMRSEPVKISDVLGSDYASWAH
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Sequence:
MSDYFEELGHEPTGPLGANDLARNLKRLQVLAIMNGIDMEIEVPEASKRAILELPVHEIVKSDEGGDLECSVCKEPAEEGQKYRILPCKHEFHEECILLWLKKTNSCPLCRYELETDDPVYEELRRFRQDEANRRERENTLLDSMFG
The following text describes a protein:
Function:
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
Subcellular Localization:
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network.
Sequence:
MEPRMESCLAQVLQKDVGKRLQVGQELIDYFSDKQKSADLEHDQTMLDKLVDGLATSWVNSSNYKVVLLGMDILSALVTRLQDRFKAQIGTVLPSLIDRLGDAKDSVREQDQTLLLKIMDQAANPQYVWDRMLGGFKHKNFRTREGTCLCLVATLNASGAHTLTLSKIVPHICNLLGDPNSQVRDAAINSLVEIYRHVGERVRADLSKKGLPQSRLNVIFTKFDEVQKSGNMIQSANDKNFDDEDSVDGNRPSSASSTSSKAPPSSRRNVGMGTTRRLGSSTLGSKSSAAKEGAGAVDEEDFIKAFDDVPVVQIYSSRDLEESINKIREILSDDKHDWEQRVNALKKIRSLLLAGAAEYDNFFQHLRLLDGAFKLSAKDLRSQVVREACITLGHLSSVLGNKFDHGAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRHTHIPRLIPVITSNCTSKSVAVRRRCFEFLDLLLQEWQTHSLERHISVLAETIKKGIHDADSEARIEARKCYWGFHSHFSREAEHLYHTLESSYQKALQSHLKNSDSIVSLPQSDRSSSSSQESLNRPLSAKRSPTGSTTSRASTVSTKSVSTTGSLQRSRSDIDVNAAASAKSKVSSASGTTPFSSAAALPPGSYASLGRIRTRRQSSGSATNVATTPDNRGRSRAKVVSQSQRSRSANPAGAGSRSSSPGKLLGSGYGGLAGGSSRGPPVTPSSEKRSKIPRSQGCSRETSPNRIGLASRRHSRSTSALSTAESVGQSDRFGLGQAGRIPGSVNAMRVLSTSTDLEAAVADALLLGDSRSKKKPVRRRYEPYGMYSDDDANSDASSVCSERSYGSRNGGIPHYLRQTEDVAEVLNHCASSNWSERKEGLLGLQNLLKSQRTLSRVELKRLCEIFTRMFADPHSKVFSMFLETLVDFIIIHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRDSFPFDQQFNILMRFIVDQTQTPNLKVKVAILKYIESLARQMDPTDFVNSSETRLAVSRIITWTTEPKSSDVRKAAQIVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLKNASNTSVGSPSNTIGRTPSRHTSSRTSPLTSPTNCSHGGLSPSRLWGWSADGLSKHPPPFSQPNSIPTAPSHKTLRRSYSPSMLEYDTENLNSEEIYSSLRGVTEAIEKFSFRSQEDLNEPIKRDGKKDCDTVSRDGGVASPATEGRGGSDVVEGGRTALDNKTSLLNTQPPRAFPGPRVRDYNPYPYSDTINTYDKTALKEAVFDDDMEQLRDVPIDHSDLVADLLKELSNHNERVEERKGALLELLKITREDSLGVWEEHFKTILLLLLETLGDKDHSIRALALRVLREILRNQPARFKNYAELTIMKTLEAHKDSHKEVVRAAEEAASTLASSIHPEQCIKVLCPIIQTADYPINLAAIKMQTKVVERIAKESLLQLLADIIPGLLQGYDNTESSVRKASVFCLVAIYSVIGEELKPHLAQLTGSKMKLLNLYIKRAQTTNSNSSSSSDVSTHS
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
LSLDSHSVMDSLNMRFDNSLESQSHREYSHSPSTCLYSRGADQTPFRSPFGCYGDPIRRDSIPYELPSCQHSGPEQAFNYEYLPDKRGSLTESGGLARFPWMRSTRTHAYPSPFPGGAPQEDTDDSKRTRTAYSRAQLVELEKEFHYSKYISRARRVELAAALGLTERHVKIWFQNRRMKRKREEAQRHRGSSSDPLKKRNDEDPGHENVL
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Sequence:
MGSEAAMAPEWASEACIMGIDEAGRGPVLGPMVYGCLYCPRSYQKTLSTLSFADSKTLKEEKREELFEILKANDSIGWAVDVIDPKELSSKMLKKNKINLNEISHDSAMGLVDRVLKMGVLLTEVYIDTVGDPGKYEAKLSKNFPSIKFVVAKKADSLYPVVSGASIVAKVTRDRAIRDWVLDESADNIHRKFGSGYPGDPATKSWLEDHKHSIFGFPTLVRFSWGTCSSYFKGGTEVLWESDLDEDGGSNNNNGKRQLKLNNLGFTTSKRRTEEIESSGKGRSRFFQARKLEHLTHF
The following text describes a protein:
Function:
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
Sequence:
MSANKKVRGEIMGISEREKLVLNAIVDYYLTVGDTIGSRTLVKKYGIELSSATIRNVMADLEDMGFIEKTHTSSGRIPTDMGYKYYLTELLKVEKITQEEIENISNVYNRRVDELENILKKTSTLLSKLTNYAGIAVEPKPDNKKVSRVELVYIDEYLVMAIIVMDDRRVKTKNIHLAYPISKEEVEKKVDELNAKIRNNEIAINDIEKFFTESTDIVYEYDDEDELSKYFINNLPSMLKNENIAEVTDVIEFFNERKDIRELFEKLIEQKAQENSKSNVNVILGDELGIKELEDFSFVYSIYDIGGAQGIIGVMGPKRMAYSKTMGLINHVSREVNKLINSMEKDKNKKV
The following text describes a protein:
Function:
Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation and adenylation activities and subsequent degradation. Stabilization of piRNAs is essential for oocyte development.
Subcellular Localization:
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Sequence:
MTATPFSPPLYMQRYQFVIDYVKTYRPRKVIDFGCAECCLLKKLKFHRNGIQLLVGVDINSVVLLKRMHSLAPLVSDYLQPSDGPLTIELYQGSVMEREPCTKGFDLVTCVELIEHLELEEVERFSEVVFGYMAPGAVIVTTPNAEFNPLLPGLRGFRNYDHKFEWTRAEFQTWAHRVCREHGYSVQFTGVGEAAGHWRDVGFCTQIAVFQRNFDGVNRSMSNAEHLEPSVYRLLYRVVYPSLCDNNIYQKTLINEVLYEAQHLRQQWLIRENMNNNAHFYSPPLMEALHHGAEGNACEQQPVYQQGGIICVPLARVWSCPRVQALCGSLQRLREKLLEDERVRMSADGSALNLPADDDDDNVEEEEEEEEEENQQNVKAVSGAVNNMEEDWDRELGSYGDE
The following text describes a protein:
Function:
Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAAQSEEDYEAGFQKNLDVDAYDDSVLKSSNMSLASEKSGSSAGEEPGSAKATKRPYTVHRASHEAYVELHELIMDRNNECRWLEASHWIKIEEDFEELGHWGRPHLSYLTFQSLMEVRRAFTKGTVLLDLPERSLAGIANQVLDQMIYEGQLKPEDREMVLRTLLLQHSHPDASTSLSNVSPARLQRSETKDVTQPLLAEHQQIEMKSFLPDPEQGEPSSTAFKKPLSEKISPDAEATLVLVGCATFLERPTLAFVRLKDAVELDSVLEVPVPVRFLFVVLGPDSPHTSYHEIGRAISTMMSERVFRNDSYLAEGRTDLVKSMETFLDCCIVLPPSDIQSEKLLKTLLPVQKELLRKRYQPMEKKVSPETELLGDLEKELKAHARKKVDDDDDDDPLRRTKIPFGGLVRDIKRRYPKYLSDIKDALNAQCLAAVIFIYFAALSPAITFGGLLDDKTRSMMGVSELLLSTAVQSVMFCLLGAQPLLVLGFSGPLLVFEEAFYKFCDDNGFEYIVGRVWIGYWLIILVVIIVACEGSFLVRYISRYTQEIFSFLISLIFIVETFVKLIKIFQEHPVKQEYINITAINSKGEPAAPQPNTALLSLVLMAGTFFIAFFLRKFKNSSFLPGKLRRVIGDFGVPIAIFIMAMADFFIEDTYTQKLKVPKGLEVSNPNQRGWFIHPLGFQNSFPILMMFAAALPALLVFILIFLESQITTLIVSKPERKLVKGSGFHLDLLLIVGMGGVAAMFGMPWLSATTVRTVTHVNALTVMSKTTVPGEKAHVQEVKEQRITGLLVGILVGLSILMEPVLKLIPLAVLFGIFLYMGVTSLNGVQLYDRILLMLKPPKYHPDEAFVRKVKTWRMHMFTLTQIACLVVLWGVKSSPASLALPFLLILTVPLRRFALPIFFTDTELKCLDCDDADVTFDETEGQDVYDEVQMPV
The following text describes a protein:
Function:
Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.
Subcellular Localization:
Nucleus.
Sequence:
MPGGTEESRPPEQQQQQQEEEERAEAAPEQPAEASSAGGGGAGSRVLRGGRERGRAAAAAAAEAAVSRRRKAEYPRRRRSSPGARPPDDAQQPATPAQGKKAAAGRVLYAEKVVTAGKDPKEEKEEEEDPPAACPEAPAAAPRPSRGWRSSSRTAVTRQRDPENTRSSRSKTGSLQLVCKSEPNTDQLEYEVTEEHHSPPGISSDEEEEEEEMFISEEEIPFKDDPRDETYKPHLEREAPKPRRKSGKVKEEKEKKEIKVEVEVKEENEFREDEEPPRKRGRRRKDDKSPRLPKRRKKPPIQYVRCEMEGCGTVLAHPRYLQHHIKYQHLLKKKYVCPHPSCGRLFRLQKQLLRHAKHHTDQRDYICEYCARAFKSSHNLAVHRMIHTGEKPLQCEICGFTCRQKASLNWHMKKHDADSFYQFSCNICGKKFEKKDSVVAHKAKSHPEVLIAEALAANAGALITSTDILGAPQEPLAPPTDAQGLPLLPEPLGTPAPGECLLLNPDGMPKAYCAGAERVNLMADGKIFVGAGGGGGGGSGGDADGLVMNTEILGATTEVLIEDSDSAGP
The following text describes a protein:
Function:
Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
Sequence:
MEVANTISQLCLKKFDDLPKNGKPEEGKQWTALAGFVKQCGDDYEVVAIGTGTTCLGESQMRKDGLILHDNHAEVIARRSFIRYLYHEILSTWQSTKTSTIFNKTNDGKCCLKSGGSFHFYTSNTPCGDATIFPISQPLNQTQSKGVKRKCEQVKLNPEKKVCIHETADEIEQATTQTQSDINRTGAKCVAGENSDRHGKGINYHCVGSLRTKPGRGERTTSMSCSDKILKWNLMGWQGHLLSLLVSEPIHMKYIIVGGVADTVALKRAFYGRIFKHEKFVSLETKINLHCPLIYKTDTEFRFGKPVFNKKHLKPCGSSLSWCKIEI
The following text describes a protein:
Function:
Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1, RAB3A and RAB10, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport.
Sequence:
MAESKDNARQPSPEKDSSLPGDLVTNGKNSKWVECKLCHSKVLRPQTAEYIKEEIFLPSMQQKTKINMDSPEGDTLHHYWLVHDMFAFENVGFSKTVNNVKYLTCADCEVGPIGWQLANDSTRFLVALERVKHS
The following text describes a protein:
Function:
Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis.
Subcellular Localization:
Cell junction, adherens junction. Cell junction, tight junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Lateral cell membrane.
Sequence:
MAVGETDGAGSEESGSREADVISRGNILESFTESQEVRALLGNLRTVYGDPVAQEVIVEKFIVIMDKYQEQPHLLDRHLEWMMNMLLDIIRDSGSPPVLFHLAFKFLYIITKVRGYKLFLRLFPHEVTDLQPVLDMIVDQNPKDCETWETRYMLLLWLSMICLIPFDLARFDGNILSEEGHTRMPTMDRILEIAKCYLVVSDKARDAAAVLVSKFIVRPDVRQKRMADFLDWTLSMLSKSSFQSMEGTVVMNGMLQALAQLFKHGKREDCLPYAATVLECLDNCKLSESNQMVLRKLGMKLVQRLGLTFVKPKVAKWRYQRGCRSLAANLQAQSSVMQSQKITVAANEAEDDEEYDIPGEIENVVEQLLVGLKDKDTIVRWSAAKGIGRITGRLPKELADDVVGSLLDCFSFQETDNAWHGGCLALAELGRRGLLLPSRISDGGLHEVHACCLCVPLINLTRICKVMLLLYLEVVPVILKALTYDEKRGSCSVGSNVRDAACYLSWAFARAYDPSELIPFINQISSALVIAAVFDRDVNCRRAASAAFQENVGRQGTFPHGIDILTAADYFAVGNRVNCYLTISVYIAGFPEYTQPMIDHLVNMKINHWDSVIRELSTKALHNLTPRAPEYMANVVLPRLLPLSVGTDLHTRHGAILACAEITHALCKLAEENNRSITYYFNGKSLEGLKQIHQELCSRQLYRGLGGELMRPAVCTLIEKLSLSKMPFKGDPIIEGWQWLINDSLRSLPLASCAARQHVKESAVSALSALCNEYYINENGEADPALQGELVTQYISELQSTEQMIRCGFSLALGALPRFLLKGRLQQVLEGLRKVTLITPRDVSFAESRRDALIAIAEICQTVGVKGEGSQEEYICKDNVAQIYATLLNCVTDYTTDSRGDVGGWVREAAMTSLMKVTLLLVQNEAELINANICKQIMCWLAQQSAEKIDKFRAHAGSVFLTLLHFDSPPVPHIPHREELERIFPRSEAETLNWNAASEAFPRITQLLALPAYQYYVLLGLSVSVGGLTETTLRYSAQSLFDYMKNIQNDSSAMEGFCETLLKVFEDNLRNDRVSVPLLTMLDQMLANGCFDIFTTQGNHPFPVKLLHLCKEEIKRSKDVRKLRSSIGVFCGLIQFQGDMREKVLFQLLLLLCHPFPVIRKTTASQVYEMLITYSEIIDPAIVDEVMAILSDSNWEAEVAELREKRNRLCDLMKVPKPQLVTKPAGTHTGAHIS
The following text describes a protein:
Function:
Sn-1-specific phospholipase A1 involved in seed oil biosynthesis. Hydrolyzes polyunsaturated acyl groups from a unique chloroplast-specific phosphatidylglycerol (PG) that contains 16:1 delta 3-trans as its second acyl group. The polyunsaturated acyl groups released by PLIP1 are exported from the chloroplast, reincorporated into phosphatidylcholine (PC), and ultimately enter seed triacylglycerol (TAG). In vitro, possesses broad substrate specificity. Can hydrolyze the galactolipid monogalactosyldiacylglycerol (MGDG), and the phoshpolipids phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA), phosphatidylserine (PS) phosphatidylglycerol (PG) and phosphatidylinositol (PI).
Miscellaneous:
MISCELLANEOUS: Plants overexpressing PLIP1 exhibit stunted growth and accumulate anthocyanin under normal growth conditions.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Sequence:
MAFNTAMASTSPAAANDVLREHIGLRRSLSGQDLVLKGGGIRRSSSDNHLCCRSGNNNNRILAVSVRPGMKTSRSVGVFSFQISSSIIPSPIKTLLFETDTSQDEQESDEIEIETEPNLDGAKKANWVERLLEIRRQWKREQKTESGNSDVAEESVDVTCGCEEEEGCIANYGSVNGDWGRESFSRLLVKVSWSEAKKLSQLAYLCNLAYTIPEIKGEDLRRNYGLKFVTSSLEKKAKAAILREKLEQDPTHVPVITSPDLESEKQSQRSASSSASAYKIAASAASYIHSCKEYDLSEPIYKSAAAAQAAASTMTAVVAAGEEEKLEAARELQSLQSSPCEWFVCDDPNTYTRCFVIQGSDSLASWKANLFFEPTKFEDTDVLVHRGIYEAAKGIYEQFLPEITEHLSRHGDRAKFQFTGHSLGGSLSLIVNLMLISRGLVSSEAMKSVVTFGSPFVFCGGEKILAELGLDESHVHCVMMHRDIVPRAFSCNYPDHVALVLKRLNGSFRTHPCLNKNKLLYSPMGKVYILQPSESVSPTHPWLPPGNALYILENSNEGYSPTALRAFLNRPHPLETLSQRAAYGSEGSVLRDHDSKNYVKAVNGVLRQHTKLIVRKARIQRRSVWPVLTSAGRGLNESLTTAEEIMTRV
The following text describes a protein:
Function:
Component of the SRP (signal recognition particle) receptor (By similarity). Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (By similarity). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain.
Domain:
The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the signal recognition particle (SRP) complex subunit SRP54 (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). GTPase induced rearrangement of SR drives SRP-mediated cotranslational protein translocation into the ER (By similarity).
Sequence:
MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQERGGNNSFTHEALTLKYKLDNQFELVFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFDFQNDFLRLLREAEESSKIRAPTTMKKFEDSEKAKKPVRSMIETRGEKPKEKAKNNKKNKGAKKEGSDGPLATSKAAPAEKSGLPVGPENGEELSKEEQIRRKREEFIQKHGRGMEKSSKSSKSDAPKEKGKKAPRVWALGGSANKEVLDYSTPTTNGAPEAAPPEDINLIRGTGPGRQLQDLDCSSSDDEGAAQNSTKPSATKGTLGGMFGMLKGLVGSKSLTREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRHQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLSALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MSTIADELFASFVDFEQVEEDQYIDLKRNKRRKLEVSKSSSLKLRYIHKNLSLAKNEMDRLRDENSKRLLRDRKLSLVLDLDHTLLNSAGFSVITDEEEYLNCERDVLPEYLKSSLFRVDLTKTLTKLRPYVNTFLKEASKLYELHIYTMGGFLYALEMAKLLDPENIYFNSRIISRDDSTRMFEKSLDVVLGKENATVILDDSESVWCKEHKENLIVIERYHFFANSCKQFGVDHKSHSQLKSDENESEGALANSLKILQQIHTLFFDMVLKSVRKEVVKGCKV
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MEEQLIQAVEIASNPLANAGPDVTSQALQFLEHLKTITHESWSVGWSVWSARNPQDNGPKYSQNARMFGLMLVDDFLANRISLSTDPAAAVATLQQSAVEYIQNEYVAGSGDASVAYIKNKFAQVLAVLLLQTYNLPPPYTLLPTLLSMIRAHPAASPSQQSTLQLPINPLTTDLVLRVLHDLSVTLGSDVTLRAVRSKERLQRDAVIRDEIRANHASNIADSVWRIVEEGFNRVNQGEHASNPNSASGVRSMNFTNAVDLTAAATKIVEDYVSWIDINLVVTNQTVPLLFNVLHHPIPKIRTAAADALHGIVSKGMKPADKLSLAQALNLPQVITPLESRTRTGPSAQNGQSDTSDSNIEFREHLAHLTNGLVLEMCKILEESAAEESTRAAAEDLLNSLLPLVLAFLSDEYDDASEQTFSGVNMILSIYKKARRRGAELTGARAEFLSNLIGVALQKMRFDDEAEWPAGSFGAAEDDDDDDDEEDAKFLEMRRSLQTIVGAIAAIDDKLFSTSVAQLVLSTFASFETSSSDSDGQISWQQIELALYVIHFYGDVMTTATAAPKVGLSPAMFVQSPEAGSKGRAPKLGNEALAGLPLSNLGEMVQKLVQSNVSSFPHPAVQLQFFECLVRYSNFFAARSGCVLDALPAFLDWRGVHHEKLGVCKRVNYLLYRFVRDLRAVAAVPMDYVERLLQGLQDLLVVRAELPQVDADEDPLIKATAPAGYFDSQLYLFETSGILVSLLNNAPNDQVVLLKAISEPLSEQMRQAVQAFQRNPTDLTSVLQVHHLMLALSSLSKGFPDLSPTSTQPEPQWVGVFKSITEQVLVSIGAMNSFSVVREAARGAFARMVSTCGKAVLPYIPGLIDALLSEVTSAELVDFVNFLSLVVNKYKDDVRSIVDQLLLILVERIFFFLNQGVTGTDDAVEKSELQKAYMNLLSSMVQSGMESVFVSDKNVGQLETVLQSVVFYSTNSDAACQRTAFSILHRLVASWAGSSAVNGSTEATLPGFERFIYEHLVPLIFEAPAKDTFDFKDAQSQIVLTEISTLAKTIFQKRGDEMIQFLLEVYLPGINCPPQLAQDFTTNLTTLDSKAFKKYLDAFITRSRGG
The following text describes a protein:
Function:
Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1. Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein. Note=Mostly located within the inner cristae membrane.
Sequence:
MLLRAAGCWRAAASRPGPVWLRGAEHRGLPLASRRLGLPLPLPLAAGGRRLRSGCGALPEVASFQGVAVRSLSTSAPSDHPEHGRLVYKGNLAKAVLGVRFFSYSTSIFNLFMAPYLMLKTGIGFDSLFLQAAFYGLIGFFTFVTPVTLHILTKGYVIRLYYKEEMDTYTAITYNAILAEKATVFHQKDVKIPDITKMFTTFYAKTKSMLVNPTLFPDPQDYNRLMGYDKAFCFDFEEEEKDGESK
The following text describes a protein:
Function:
Protein-L-histidine N-tele-methyltransferase that probably monomethylates RPL3. Through the methylation of RPL3 may regulate the dynamics of pre-rRNA processing, ribosome biogenesis, and translation.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Nucleus, nucleolus.
Sequence:
MSFKFNFQVDEDENDNGNNNEQNNEESKLDISEFDSSSKMDELPSKYIDLRNNLSSLLSNVETEIVTFSSNNKLKKLVKPFKGNQDNNNDNNVNSNDKNDNNNNNNNNNKDYEKLLDKTDLIPGVYEGGFKLWECSIDIINYLFEEKIDLSGKKVLEIGCGHGLPGIYCLLNGSIVTFQDYNEEVIYNLTQPNVLINGGDINRAKYISGDWKFVDQLLKNEKFDIILTSDTLYNVGSFKKLYNLISNHLESNGKCYLASKTYYFGVGGGIRKFEELLKILNRLSIKTVRDIKDGLSNVREVVEITNKIN
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MVKREDTDDTSTQAVDGAEVESNGQGDAGTDSSPWSIESETVLFNSLCKFKPVGIHKHFRMISLSASLNYYFSESPKDAPVFSHQDVWDKLGTLYDLDGLDELEYVADNQDSDMDEDEDDEAAIEGIAKRSQMKEFVLPFRDYGFLQIEQATAVASEQSSPAMSREQSVLEDGPTAGDEKKGLADDDDESSDLDELDDEEMKLAETKIKVEGEQQEREENGGEEEHDTMEGSAEPEEAEKSEEEGEGEESGESESESGSESQSDSDAQTGRQRRTRAATAAAVRGRGTSKGKTVRDKKSSPSTRASSAPRRSTRRKATTEPEDTATEREETPTPKKSSGGVKKPAPRRSTRRKK
The following text describes a protein:
Function:
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Subcellular Localization:
Secreted.
Sequence:
QHWSYGLRPGGKRNAERLGDSFQEMDKEVDQLAEPQHLECTVHWPRSPLRDLRGVLESLIEEE