The following text describes a protein:
Function:
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors.
Sequence:
MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECVSLITKPNFISTLCYAIDNPLHYQKSLKPSPHLFTQLSKVLKLSKVQEVILGLALSNSSNADLRGFAAQFVKQKLPDLLRSYVDADLGGNQEGGFQDIAIEVLHLLLSHLLFGQKGSSGVGQEQIDAFLKTLCRDFPQERCPVVLAPLLYPDKRDILMDRILPDSGDLNKTMMESSLADFMQEVGYGFCASLEECRNIILQYGVREVTASQVARVLGMMARTHSGLSDGISLQTITNPVGGGGIWSDGKDKSDSSQAWNVEVLIDVVKEVNPNLNFKEVTYELDHPGFLIRDSKGLQIVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLLSPEVFCFADNPCHTVAIDTLKAPPEDDNREIATWKSLDLVESLLRLSEVGHYEQVKQLFSFPIKHCPDMLVLALLQISTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHSMAEWYMRGEQYDQAKLSRILDVAQDLKSLSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACVTFLKRRCPSIMGGLAPEKDQPKSAQLPPETLATMLACLQSCAGSVSQELSETILTMVANCSNVMNKARQPPPGVLPKGRAPSTSSLDAISPVQMDPLSAMGSLSLGVSSTSHTPSMQGFPSLQGSAFSNPQSPAKAFSNLPNPNPSTAFPGINPLSSQLQGPLSTSLSGIGSGLGMPTVSSDVFSARKMSTPGLNPPTFQQTDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPTMSVDEVLEMLQRFKDSNIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASIAHFLQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSLALAQAQAQSQPPKAPQPGQASTLVTTATTTTTAAKTTTITRPTAVGPKKDVPPSINTTNIDTLLVATDQTERIVEPPENVQEKIAFIFNNLSQSNMSQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFVKMVLNETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILYTDLELKSLLLEAYVKGQQELLYVVPFVAKVLESSLRSVIFRPQNPWTMGIMNVLAELHQEHDLKLNLKFEIEVLCKNLSMDITDLKPGNLLRDKDKLKTLEEQLSAPKKETKPPEELLPIVTTDSVPFTAAPSTPATTTACTATGPPTPQFSYHDINVYALAGLAPHININVNIPLLQAHPQLKQCVRPAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESHMRVAAHHMMRNLTAGMAMITCREPLLMSIATNLKNSFAAALRAPTPQQREMMEEAAARIAQDNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPMVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNVPGFLPSNDLSQPTGFLAQPMKQQAWPTDDVAHIYEKCISDLEQHLHAIPPALAMNPQTQAIRSLLEAVVMARNSRDGIAALGLLQKAVEGLLDATSGADPELLLSYRECHLLVLKALQDGRAYGPQWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKLLLVDERSVSHITEADLFHTIETLMRTSAHSRANAPEGLPQLMDVVRSNYEAMIDRHHGGPNFMMHSGISQASEYDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHPTTSPAIIRAKCYHNLDAFVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLIQDHDVRQTEFQQLPYHRIFIMLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVELNKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNFTGVMPSQFKKDLDSYLKTRSPVTFLSELRSNLQVSNEPGNRYNIQLINALVPYVGTQAIAHIHNKGSTPSMSTITHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANAEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWSHDFVHCAPEIEKLFQSVAQCCMGQKQAQQVMEGTGAS