lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts to sequester alpha-tubulin from interaction with beta-tubulin, raising the possibility that it plays a regulatory role in the formation of the tubulin heterodimer.
Miscellaneous:
MISCELLANEOUS: Present with 656 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.
Sequence:
MVRVVIESELVRTEKELPNSLKLRQFKDRLYHVTGVEPEDMEIVVKRQYDNKEIYSTKKGGAYSNEDEDANFLKGEEELIVVVTDSNAQSISNQLATQAEGIPSMEVISEEDYLRRDQSVLRWKMAHGYGRFNAAQQSQRAALAKQDEAYAREQLTAAIGRHCRVTVDGSAPREAILRYVGPLPLDVMGTWCGVEFPEAAGKNDGRINGVTLFGPVAPGHGSFVRPRAVEILSKDEESAEVEDVHDDVESDDEI
The following text describes a protein:
Function:
Stabilizes the proteasome holoenzyme, probably by tethering the 20S proteolytic core particle and the 19S regulatory particle. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAENELRLLNNAELKLALAESEDSFQSLVSVFLCPILLKLDSPHESVRNKTISIANHIMTRLNNNAQAILPLEALVSQYVEANQPLRKRFLLAFISIGEKRIPCSENLALLQICLNHVNEYPLVLLTLTIRLLRFSKPTSAITCSNDVILSLSSFYLIQKDQRIFSDLQFSQKTVDYRLSLLRWIHLSSWPSNWKWLAYFFASADSHSEVARLADEFTRDSGLPDLENLSHVNVLLDIALDKFRIEALHANFSVSISLRNKAIQHLLKSKIAANTDKAINCIEFILEAPPSMQPRLIQFTRWVVDKADPNFLKPKAAMILEKILSILSSNIIQSDLLRGFLYTTIGLLTKVDNHLITNSLLTNLLTSLQSELPDVRVSIDEALSIIIPYYSNFRFSNELLPVLEPFIFDSPESPAAYCALRFVLVAFPFDYLPARFICLKVQNPFVFHHSFIEEAKKGLNLSQWVQYNSVYSTNEAQEEDKVRAASYPSASEVISFILSDHDLKKFWESNAAEYCLAILEFIERCIYYSADRSLELYDNDKLSSIDALLIQDSKLREMVSEKCISLSNFNVFLEYVFYGTLLMHFEPTYALSRLVSFAPPEVTFSLPELDFLTSVFNFPLALRNTATRILGIILSTKDSTRISEVLSSCFTIISTSNNKNDNFFKAETALLIIGYTISYLAAQTNSAAVDSFILNSGSIKEFFSVLLEYLGSNVLHKKTTSLAIYKELFVYFTRDWITSYGVDFDEILNVLLRFLKEVEDTNVKVECLHVISRMSLSFSDDEMAEKILKAIYVTYHMDSPDILFASAEAMSILAGGHRNVFVKSTCPIFFQKQLDNYKADHYCFTLDFILTDCVNSPKPLLRRASSLWLFYIVRYCEPQTYTMTRLNDIYHSFLSFLVTQDDFVQDTASRGLKAMYDVLEGDERKSFTDNLISTIAADRVDEKTKAPLDADTALFTTNKGTVATYKDICSLASESGNPDLIYSFLSIAGNSSLWQARKGLASGISYLGIPEDQKRKTFSFDTSKSSSLLKKLYRFKHDPNPDVAKTMGEIWDTLVPSDLNLASHRKYLVEDCLEFMGSRSWRDRESSVNTLVSLLSNVPVTEYLNQLEDIWNMSFRTLDDIKESVREASFPLCKLLARSVIQSLEKTSHNTSPSGICKGKRIVSVALPFLLKHAYDQAKEVRSLTYSTITELVRTGNSTLTSFVPAIMQVMLEYLTEYESKAATFLDFHAKNYSIKQENIDNARTSAVQSSSMMDTLEKCIGLLDESSMQTLYPILNRMIAKPGGVPTKIGSAQVVMLLVIRRGPLVKQFASKLLQSLKSSCFDRNAAVSDAFASAIGYLLRVCPLEIASQTCQEIIDKFYDGNTNEQIISSKLTVYASRYAPDVFLNLGSLFFPFIFFGKHSSSISINGVLSKAWDELSSAGSSVNLYSEEIILLIQKNLIVTKWDVKRPAAAALLEFVNTSRLTYRQNDIYVLLNETMKDKSWPGKELLLEAYVKFLIKYPEFIKSQKMEEVHQVIVREFKRRNIVYKSHAMESVGELLSDENYRELDLYELSLNECGTFLQKEWFDKDDELNLEEKIALQRNSVYAMFNSSRPGNKNCNEMLLTYLSNALDENYLHWNVKLAILKNAPHLKKIMSNEEFLLYKDILYRCYEDNPSPKAKDYAEVIFGENYLSVLRN
The following text describes a protein:
Function:
Forms a receptor complex together with receptor ilcr-2, which upon activation acts as a modulator of neuronal activity. Binding of the ligand ilc-17.1 to the ilcr-1/2 receptor complex triggers a signaling cascade that activates the downstream signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MFLHSPALLIWLFLFCLAGPQAVRTEPYNSTSSSSSPTANDVTSSDLLLLASEETPTRAPKPVTKQGKKNVVKVKKGGNGTVDDSPWVTDCSEPLNKDISCSVNIIGCSDNVFKYVDAGQEPPRAHDVRIAPTTKVMGANRIDKRKHRLHVDVSWQIPQLEASTHLKAFKLIVNGPDGKNTCFVFNVTQTHVDDEGISPRYRFSSNTLFDFGHNYTVTIVSLPMSRKRAPKVSATSLMPDDPDAAPVKIVKTNEQMCEGKSNPQASKWAASFRKIFLFSAIRLIQIEFLAAPPQYCFEEYEVRLLDSSGIVMLQSAIITKDELRTEIINGRPVQFGEFNFTDIELDTDLIPSVIPIESAHDGRCLCVTENGCSCLAADWKPVKLTRIEKPPATSNQTEESDGKAEKDKKEDTTWTWHTYAITGGAIIAILFILSVCAGLKCYKKFNNKKKASNIHLLNENPAFSHSGSIPLILKQSISVLIVYSHDSAQHEAAVLAFAELLRDVFNLNVHLDVWDEDDIEENRAEYINSSIVRANKVIIINSIGAYFRTVFRHQREPAIERITTGRNDVIFDMQCELALQHPCVISCHFSYTNPKYVFFPINRLLQYSIPNSLMTMTTALTEQPARPEQLAGFNQVFARLQAAISRKLNYIESDPQWFENTHHRVATRRVSELEAHNIVPLPPSLEVKVEDEDAFGQMETLPIDELKEKFAAKRDLEVEVLDSEDVKLLEDVKCAPGPIHVEPTEPEVLEPAEEPMEEAEEDEEDEDDVDSVEGQTARIEELQRLIVHKDMNHDSGNLDSAYVSGSDFSADIHNEILDKPRLNAEMDLRKANREDSAFHDEVIGIH
The following text describes a protein:
Function:
B-type di-heme cytochrome. Catalyzes the oxidation of superoxide to molecular oxygen and transfers the extracted electrons to ubiquinone through the two hemes. Can also use menaquinone. The enzyme may be responsible for the detoxification of the superoxide anion produced in the membrane or at its surface. However, it can also efficiently catalyze the formation of superoxide from ubiquinol under physiological conditions.
Miscellaneous:
MISCELLANEOUS: The low-temperature difference spectrum of cytochrome b561 shows an alpha-absorption peak at 561 nm and a minor peak at 555 nm.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MENKYSRLQISIHWLVFLLVIAAYCAMEFRGFFPRSDRPLINMIHVSCGISILVLMVVRLLLRLKYPTPPIIPKPKPMMTGLAHLGHLVIYLLFIALPVIGLVMMYNRGNPWFAFGLTMPYASEANFERVDSLKSWHETLANLGYFVIGLHAAAALAHHYFWKDNTLLRMMPRKRS
The following text describes a protein:
Function:
Required for chloroplast development and integrity. Involved in the regulation of plastoglobules formation.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAVSFNTTLHQPSLSPSCSIKLYSGLKPQSASFLASGYQNLNKEFYGRVYKSLQSGTGKASRSRVKMMPIGTPRVPYRNREEGTWQWVDIWNALYRERVIFIGQNIDEEFSNQILATMLYLDTLDDSRRIYMYLNGPGGDLTPSLAIYDTMKSLKSPVGTHCVGLAYNLAGFLLAAGEKGHRFAMPLSRIALQSPAGAARGQADDIQNEAKELSRIRDYLFNELAKNTGQPAERVFKDLSRVKRFNAEEAIEYGLIDKIVRPPRIKEDAPRQDESAGLG
The following text describes a protein:
Function:
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
Subcellular Localization:
Cytoplasm.
Sequence:
MKSILENRPALAKEVNKVAEVAGYLWQKGWAERNGGNITVNITEFVDDEIRRMEPISEVKSIGVTLPYLKGCYFYCKGTNKRMRDLARWPMENGSVIRILDDCASYVIIADEAVAPTSELPSHLSVHNDLLSKNSPYKASVHTHPIELIAMTHCEKFLQKDVATNLLWSMIPETKAFCPRGLGIIPYKLPSSVELAEATIKELQDYDVVMWEKHGVFAVDCDAMQAFDQIDVLNKSALIYIAAKNMGFEPDGMSQEQMKEMSVAFNLPK
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Sequence:
MTSSKQRLIQGMHQDLSCPVCLKLFQSPVTTECGHTFCMDCLSRASKDEDGKATSCPVCQAGTKVEQLCINKQMENLVQSFKQVPQDHCEEHLDPLSVYCEQDQQVICGVCASLGKHRGHNIITAAEAHQRMKKQLPQQQVQLQEAQVRKEKTIALLNRQIAEVEDTVSRFKQQVSEQLGVMRAYLGALEASLGREAERVQHQATDALQSERKTMTCYLEQLRQMETVLGEVQDEPQTEFLRKYCLVASRLQKILGESPPIARMDIQLPIISDEFKFQVWRKMYRALMPALENLAFDPDTAHPNLVVSDDGKRVECVEHKQAVSVDDPQRFDKANCVVSRQSFSQGEHYWEVTVGDKPRWTLGVISAETGRKGRLNPLPSNGFWVLGFKDGKTYEAHVEHKEPRALKLENKPTCIGMYLSFDDGILSFYDASDEDNLVQMFAFHERFTGNLYPFFDPCWHDKGKNSQPLVIYTPEPEK
The following text describes a protein:
Function:
Subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Specifically required for the cleavage of the final glucose.
Miscellaneous:
MISCELLANEOUS: Present with 9760 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MVSMFSLFLLLIEQSPLVASLQQSQRHIVGVPWEKQHLYDSNEPDLTKWHCLNHEDIVLDISQINDGVCDCPDGSDEPGSAACVEDIFKSVAEGGGKVNKYFYCDNKGFIPRYIRKSEVADGICDCCDCSDELLSGYELFDAGSNCSQLKNEFDIMASKELSSYREGKEALEELERKYGTKEEAITRGNCLEEDKEKASAEIKVLSNRLSENRAKLEQLRGEYFNQLSHDPILYQFEQLNSTRLGSDILTSFTMVSRVSKGYQDIFKILSDLSEAYTPSLNDKVVNDNIKKFRKVRRRAEKAKINADSKIDDEQADNLYLYFTEEVPQIFLKRESENTLRYVIGKSNFVQALVEGKINYTNDILEYIREFRLIMDDISQNYNVNFQDAGVKSAVDSYKNYLGEYGELAELEPAHPSESLLRSLSEVTSFVNENAPKVLPPDAVESEQDTNSDHIGTSGDLRNKLKEILSKLNIFSSRKDLVSLEKRFRSCESQVSLLENELKQKMDYKKLLDETEDEGTNSTAGNLTELLELMGSQSYCLDDILDNYVYTICFQRPMTEGVIYQAEDKVDGKKVLIGRFKTSGFNVDLNMEKYAEHLKATYDEKSDLISNLAAIQDDDGNMQHYVFGNLNELNNGLVLEYENGDQCWNGPRRSATVFVRCSDKFKIRSVHEATKCNYIFDVVGPLGCNKTFEYEPPKFNLSE
The following text describes a protein:
Function:
Transcription factor. Probably binds E-box motifs 5'-CANNTG-3' in complex with transcription factor TCF3/E12. Negatively modulates transcription of target genes such as CDH1/E-cadherin, perhaps by recruiting the PRC2 repressive complex to regulatory elements. Regulates ameloblast development and tooth germ growth, perhaps acting by positively modulating migration of inner enamel epithelium (IEE) cells. Plays a role in enamel formation.
Subcellular Localization:
Nucleus.
Sequence:
MNSNFCRALVDRGPPGGMQLGVVAPAGQTPLAATEPLSNVPFLLYPGHSEPPYYDAYTGVFPYVPFPGAFGVYDYPFEPAFIQKRNERERQRVKCVNEGYARLRGHLPGALTEKRLSKVETLRAAIRYIKYLQELLSATPDGAPPPATSPPPAHTGHSNVPQPSSLVAESSGSPFSSSPFLESEEPSL
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MSSDKKAPVDLGLLEEDDEFEEFPAEDWTGLDEDEDTHVWEDNWDDDNVEDDFSNQLRAELEKHGYKMETS
The following text describes a protein:
Function:
Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKTVPAMLGTPRLFREFFILHLGLWSILCEKATKRNDEECPVQLTITRNSKQSARTGELFKIQCPVKYCVHRPNVTWCKHNGTICVPLEVSPQLYTSWEENQSVPVFVLHFKPIHLSDNGSYSCSTNFNSQVINSHSVTIHVRERTQNSSEHPLITVSDIPDATNASGPSTMEERPGRTWLLYTLLPLGALLLLLACVCLLCFLKRIQGKEKKPSDLAGRDTNLVDIPASSRTNHQALPSGTGIYDNDPWSSMQDESELTISLQSERNNQGIVYASLNHCVIGRNPRQENNMQEAPTEYASICVRS
The following text describes a protein:
Function:
Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hippocampal mossy fiber projection.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: GPI-anchored form.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MVGRVQPDRKQLPLVLLRLLCLLPTGLPVRSVDFNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHALEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPLGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFRPGSVRGINGSISLAVPLWLLAASLFCLLSKC
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MVDQDSLLSSSATGLGFSVLFQALSRVLNFIVNQFTIRLSNPLAYGFATIKLEVLQSTILFLSREAIRLALQRSPPKSKYAEGELKLPYKFKTKEGQRQVIINVSLLPLYVGFGLCLILTPIYLKSSVAVNSASLAIGIYVVSSLLRLLSEQLYQQLQWEERFARRASCEGYGVVSNCFATFIFTLFERGRSSTCLPFAIGNFVESVTCFYFLWKATGFNRVFFVPTPVNFDGKEILWDKDIITNLGGQSYQLVLKHVLTEGDKLMASWLATPTVQGLFALATNYGSIFARILLRPIEEQAHIVFAQLNTDNTTDGKKKASDVASLFIRLYLYLALFVVFGSPYSLLLLNITAGRQWSGSDAASVLSIYAYYVPVMAINGITEAYFVSTASVQEIISQTRYMLFISVAYFLSGLVFLQWFSLGPAGFIYSNMLNLGLRIIISIRYMYKRLPNFKLKDCSPGAPLFLLSLILRAVTQYTTNLWKADQLNTLLYIASAAFSASLFSICIAYYDRLFFKSIRFNTVRNDTKPKDTKKNA
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MEEKLSVRAEGYQKDFLRRFGAGGGGQGEGTEGGESEDIELSLGLSLGGRFGVEPKEKRLVRSSSISTLPVERDLAMVPPLARTCSLQAEAQEELRKRKELQSLKRLEAKRRRSEKLSSKSRIADRKGDIFDEETAGSRNRVAPHGLPLWIAGAGRAAAQPTEAPRRFGLVSQGSIGSQGSSCSSVSDVESQPKQGSRNSPRVGSPMTAMLSPEHGSHKAVSDHTTAAAVGKHVAGVTGEEGQSRKATEGALDDRVREKAGRNMVERMPCVSTRGDGPNGRRIEGFLYKYRKGEEVKIVCVCHGSFFTPAEFVKHAGGGEVAHPLRHIVVDTLPSAFL
The following text describes a protein:
Function:
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
Subcellular Localization:
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Sequence:
MAKEKGRKLIAQNKKARHDYQILDTYEAGLVLSGTEVKSLRQGRASLADGFVQLDGHEAWLHNVHVPEYSQGTWTNHSARRKRKLLLHRVEIDKLESKSQETGHTIVPLALYFKDGRAKVEIALARGKKEYDKRQTLREKQDRREAERTISAIKRKQRA
The following text describes a protein:
Function:
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Presynapse.
Sequence:
MEDTYRDRTAFIRGAKDIAKEVKRHAAKKVGKGVDKMQDEYTKRSYTRFEEDDDDDYQPQDGYYRGDPLNDEEGASSDATEGHDEDDEIYEGEYQGIPRADSMKGDHLANNQQLVTEFKDFNDLEGQRKKDKEELAQQYEVILQECGHGRFQWTLYFVLGLALMADGVEIFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGMADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTQIKTIKQDDELVEIQSDTGALHRRWMIKLLNLSQEVWANFHQCFAPEYRRITLMMMAVWFTMSFSYYGLTVWFPDMIKHLQNIDYASRTKYFHNESVNNFNFNFTLENQVHRKGEYHNDKFIGLKLKSVIFEDSLFTDCYFEDITSSNTFFKNCSFIRTMFYNTDLFDYKFINSKFTNSTFLHSKEGCQLDFSDDINNAYMIYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCISCFFLFFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGVAKAVPILLASAALAVGSFLALKLPETRGQVLQ
The following text describes a protein:
Function:
Positively regulates the expression of ytmI operon in response to the availability of sulfur sources.
Sequence:
MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLGVLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTASLIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFFYDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKMELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHFDRATKDLIARITKRFQQRSKELEGTSDKTITG
The following text describes a protein:
Function:
Is a modulator of endothelial barrier permeability, required for proper organization of endothelial cell-cell junctions and cytoskeleton. It also plays a role in the modulation of secretory autophagy (By similarity). May affect blood-brain barrier permeability.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction. Cytoplasmic vesicle, secretory vesicle. Note=Localized to Weibel-Palade bodies, secretory granules characteristic of vascular endothelial cells.
Sequence:
MEKWTAWEPQGADALRRFQGLLLDRRGRLHCQVLRLREVARRLERLRRRSLAANVAGSSLSAAGALAAIVGLSLSPVTLGASLVASAVGLGVATAGGAVTITSDLSLIFCNSREVRRVQEIAATCQDQMRELLSCLEFFCQWQGRGDRQLLQSGRDASMALYNSVYFIVFFGSRGFLIPRRAEGATKVSQAVLKAKIQKLSESLESCTGALDELSEQLESRVQLCTKAGRGHNLRNSPDLDAALFF
The following text describes a protein:
Function:
Transcription factor that acts as a repressor.
Subcellular Localization:
Nucleus.
Sequence:
MAEDTYSHKMVKTNHRRCRTKFTEEQLKILINTFNQKPYPGYATKQKLALEINTEESRIQIWFQNRRARHGFQKRPEAETLESSQSQGQDQPGVEFQSREARRCRTTYSASQLHTLIKAFMKNPYPGIDSREELAKEIGVPESRVQIWFQNRRSRLLLQRKREPVASLEQEEQGKIPEGLQGAEDTQNGTNFTSDSHFSGARTW
The following text describes a protein:
Function:
Gatekeeper of meiotic initiation in both male and female germ cells. In complex with STRA8, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis. Temporal expression of MEIOSIN is required for meiotic entry decision.
Subcellular Localization:
Nucleus.
Sequence:
MLGSDKFSCFSDQHRARSPSPTDRKDKKNHTNKLRELALLIPVTMKTRDKKYTKKEILLRVLHYIQYLQRNIDMTKALLKLHSSNGKGRFVGPGLNPSAGQTQQQHSTPSSSQKPSLWSTSSKPRKKKFTRVSEHPSWPYNPRRSLALDQAENPNTIHPGLKEENEECATYPGVLSPSTYPTTEPSVSEGDGQGAQLVFLDMAQNIFAYDILSDHAVEVQGGEPNADIKVQRSFFLTRAQPCVSSCRQKLFLCTSSEADKEAPDSDPWLPVWTSEDSPNGSPLALGSSQINTWHVADYLNEILGVSSSLFSSPSKILPDHVLEDGTYFLTEGLLESSPATCEVESPQEKEVSSEGPTGPPNFQSSVSLDHCYLSLSENVKVLSNCGSSSESTDTESLWGQEEVRGVATYPRRTGVFSLAQPSVLQQANPEGLQTSSDEDRDYTWTPTGQSSGLPVASKKIKKVQASQGPVKPKDSRKACPGQVKKKCVNGFIMFCRMNRKQYIRACPGTASTAATKDLAQLWRGMTLEEKKPYCTKARRFSRQNNRIVKQENSSSEDDDGETPKPFYQLLAEKAQVSLGLTSLPTPNCQ
The following text describes a protein:
Function:
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Sequence:
MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAALLAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIGPGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVPVNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTLTGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE
The following text describes a protein:
Function:
Catalyzes the oxidation of racemic ipsdienol and (4R)-(-)-ipsdienol to form ipsdienone (2-methyl-6-methylene-2,7-octadien-4-one), an intermediate in the biosynthesis of pheromonal ipsdienol in male pine engraver beetles. In contrast, (4S)-(+)-ipsdienol is not a substrate.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MMVKIQDSVYLVTGGGSGLGEATAKLLLTEGARVTIFSRNEYKNEFPHDQVLSVKGDVRSESDVKRALEATIQKFGKLDGVMHCAGVFQNGDELFNMDTQQPGDYTVLTDIVTTNLLGTFNVNRLAIPYFLTNQPDEEGQKGIIINCSSTSGHSPMSSAVAYSTSKAAIIGLSYALAKQLSTLGIRVMDIAPALCDTPMFRRAVGFNQDIANFRNLFPARLIQPIEYANAVKHIIETPMLNGSSYQLDGALRP
The following text describes a protein:
Function:
Catalytic component of the MIS complex, a complex that mediates N6-methyladenosine (m6A) methylation of meiotic mRNAs and is required for initiation of meiosis, progression through the meiotic divisions and sporulation. M6A, takes place on the adenosine of 5'-[AG]GAC-3' consensus sites of some mRNAs. Positive regulator for IME2.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Note=Localizes in the nucleolus during the period of m6A mRNA accumulation.
Sequence:
MINDKLVHFLIQNYDDILRAPLSGQLKDVYSLYISGGYDDEMQKLRNDKDEVLQFEQFWNDLQDIIFATPQSIQFDQNLLVADRPEKIVYLDVFSLKILYNKFHAFYYTLKSSSSSCEEKVSSLTTKPEADSEKDQLLGRLLGVLNWDVNVSNQGLPREQLSNRLQNLLREKPSSFQLAKERAKYTTEVIEYIPICSDYSHASLLSTSVYIVNNKIVSLQWSKISACQENHPGLIECIQSKIHFIPNIKPQTDISLGDCSYLDTCHKLNTCRYIHYLQYIPSCLQERADRETASENKRIRSNVSIPFYTLGNCSAHCIKKALPAQWIRCDVRKFDFRVLGKFSVVIADPAWNIHMNLPYGTCNDIELLGLPLHELQDEGIIFLWVTGRAIELGKESLNNWGYNVINEVSWIKTNQLGRTIVTGRTGHWLNHSKEHLLVGLKGNPKWINKHIDVDLIVSMTRETSRKPDELYGIAERLAGTHARKLEIFGRDHNTRPGWFTIGNQLTGNCIYEMDVERKYQEFMKSKTGTSHTGTKKIDKKQPSKLQQQHQQQYWNNMDMGSGKYYAEAKQNPMNQKHTPFESKQQQKQQFQTLNNLYFAQ
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSGNPVTRWAFVDFGVGLGLGSAYIECSQKFGGYPTKFLPPKISNVPSQVGAIQTYKLFYIGFNLWNLLVVFSYSLLYLTLRLVLGAYWLLLYTCLRKQHQNVIF
The following text describes a protein:
Function:
Serine protease involved in intramembrane proteolysis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPLNTPYPVEKNTFNISDEDDDFPTRNLNESSPLTQSTKRYMKQDFANSVTSLPSLPPKPSHLQPQNRPQHQQQQQQQQYPYGNLSAKQSNKHKQMFENSVPETNKKDYLGNTTTVRELPPIPDNEKLHSKNPFSDSRYASRDYDDVDLPPSPPHSDPFRNDEISDDDSHSDLKHKMKRNEKNRIRSLRRKPRFHYTKLPYFTMVISLIQIIVFIVELAKMAHLTGSAFQTKPYFNPMLGPSTFLLINMGARYVPCMHQIKDITDDTSILFPCANSTSVDTYVCSLSELCGLTKLKLSSDGSAYLPDQWYRIFIPIFLHAGFLHIIFNLLLQVTMGSSIERNIGIIKYAIIYISSGIGGFLLGANFTPQGIASTGASGALFGIVATNIILFIYTGKKNTNMYGTKHYALFICIMIGEIVISLVLGLLPGLDNFSHIGGFAMGILSSIVVLKDPFWVFIDGIITYPKNPSTWQQFLNNWNPMYSIEDKIRSRFFIWCGVRIIALILMIIYLVLLCKNFFNNDINRGNNCKWCKYFNCIPVKGWCDIGQVSVTSTTTTSDSNSNSNSNSNPTTTASSSSSSVPTTRYSTMTYTTSMPSSVENPKSNTNSEGTNGGLRKRFASSFTGGNSGGTANIAARAGGDIQQQYGIGSGLYVIVIFFTISFLKKKKII
The following text describes a protein:
Function:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
Subcellular Localization:
Nucleus.
Sequence:
MVNKFKADELGTELSRRGPSAAGTNPKKERLDSAHGKEKHSGVSAGKKRQRKLRVDDLDGIKKIKAIEDLHEQEILRSISSSGSKSELMASPCAVESNDLADAHDGLSVREQNEAKETSKEEKQLTNKKKGSAVLDQHLPDHIKTQYHVLEQGDNIYDATLNQTNVGDNNNKFYVIQALESNDGGKFMVYTRWGRVGIKGQDKLQGPYASREGAVQDFEAKFFSKTKNHWSNRKEFICHSKCYVLLEMDCEADQKSDVQEKPAIGSHLQASKLDPQIANFISLICNPDMMKQRMQQLGYNPERLPLGKLSRSTILKGYDVLRRISDTIDKSDREKLEELSGEFYTIIPHDFGFRKMRDFIIDTHYKLKCKLEMVEALGEIEIAASLFKDDIYSQADPLYSHYQCLRCELVPLKVGSAEFSMIDKYIHNTGDETHYRIDIVHLFKASREGEDERFKKFSNAKNRMLLWHGSQLTNWTGILSQGLRIAPPEAPSRGYSFGKGIYFADMFAKSVRYCGADWVNSDAVLILCEVALGDINEIQTFDHSPHQLPKGNLSAKAIGRTEPDPSKVEILEDGIIVPQGKPIDQTKPKAVWGMNEYIIFNVDQIRIRYVVHVKLCYNGVN
The following text describes a protein:
Function:
Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Probably by regulating lipid storage and catabolism, plays a role in neuronal function.
Miscellaneous:
MISCELLANEOUS: In Norse mythology, Heimdall is the fictional character that for ages guarded the bridge to Asgard without sleeping and without the consequences of sleep deprivation.
Sequence:
MNDLKPATSYRSTSLHDAVKLRLDEPSSFSQTVPPQTIPEFFKESCEKYSDLPALVWETPGSGNDGWTTLTFGEYQERVEQAALMLLSVGVEERSSVGILAFNCPEWFFAEFGALRAGAVVAGVYPSNSAEAVHHVLATGESSVCVVDDAQQMAKLRAIKERLPRLKAVIQLHGPFEAFVDHEPGYFSWQKLQEQTFSSELKEELLARESRIRANECAMLIFTSGTVGMPKAVMLSHDNLVFDTKSAAAHMQDIQVGKESFVSYLPLSHVAAQIFDVFLGLSHAGCVTFADKDALKGTLIKTFRKARPTKMFGVPRVFEKLQERLVAAEAKARPYSRLLLARARAAVAEHQTTLMAGKSPSIYGNAKYWLACRVVKPIREMIGVDNCRVFFTGGAPTSEELKQFFLGLDIALGECYGMSETSGAITLNVDISNLYSAGQACEGVTLKIHEPDCNGQGEILMRGRLVFMGYLGLPDKTEETVKEDGWLHSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHIEELIKKELPCVSNVLLIGDHRKYLTVLLSLKTKCDAKTGIPLDALREETIEWLRDLDIHETRLSELLNIPADLQLPNDTAALAATLEITAKPKLLEAIEEGIKRANKYAISNAQKVQKFALIAHEFSVATGELGPTLKIRRNIVHAKYAKVIERLYK