lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.
Sequence:
MNNFKTSTKSDKIKVLNVAEKPSVARSIANVLSKDHRIEETKSPFNKLFKLDYRLKDVEVEMWITSVTGHLKSLKYPQKYQSWEKWDPIIILKEAEIENNISTDKQNLELNLKNFASICNRLILWLDCDREGENIAFEVMEVCREANPNIQVNRAHFSAVTYVDVRRALDTLKYPDQNLSNSVIARQEIDLRIGASFTRFQTLLLQKQFNLSSIVSYGPCQIPTLGFVVQRQKEIDSFVKEQFWFIQSEDDQKCIYNWDRTHLFDEFIVALLFERCYQESATVINVQQKDVQKWKPYPLCTIEFEKLASKKLRISAHKAMELAERLYNKGYISYPRTETNKFPPTINLQTIIRDQQNHPVWGEYATNLLNFAFEYPKAGNKDDKAHPPIHPVKMMIENEAQNKQEWDVYQLITRHFLACCSKNAKGSETTITLQINDETFSKSGLVIKEKNYLEIYIYEEWSQSQVPNYQQGDSIKIKLTLQKGSTSPPKPMTEAELIGLMDKNGIGTDATIHEHINTIQDREYATKRGQIIKPTKIGLALVESYEILGFTLHQPFLRAVMEQRMNEVALGKKEKSQIVQATINEMTIILKQLQEKQNLIIKTFGSYLEALKNYDEDNDNDDNNNQPRIPLDEGEETTQNQPKANKKTRNQRNKKSDELPKNSILPPSICQFCNSLCVTNKQLNGKLIQICPKLCQIQEDINQNGHHQSTQNKDNCFQCNLCQNFMKIRYSKIKKTNFLGCSSYPQCNQAIFLPDTVKSIKLIDKKCTKCGSPLFSLQFNENYNQVHQASFFCLFPGCQFIIKTDWKQNKDSNQTSFVGKQQNKVENTGKYPFNPHQQNKNFYNKEKSNNQQKFPYQKN
The following text describes a protein:
Function:
Involved in the 3-hydroxypropionate/4-hydroxybutyrate cycle which incorporates carbon dioxide into cellular carbon. Catalyzes the ligation of coenzyme A (CoA) to 4-hydroxybutyrate (4HB). It can also use butyrate, valerate, propionate, acetate and 3-hydroxybutyrate (3HB) as substrates.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MVTVQDFFRKFIEFQNSPNEKSLQEIVKLVGQLDLRRFNWVRDVFEDIHVKERGSKTALIWRDINTGEEAKLSYHELSLMSNRVLSTLRKHGLKKGDVVYLMTKVHPMHWAVFLAVIKGGFVMVPSATNLTVAEMKYRFSDLKPSAIISDSLRASVMEEALGSLKVEKFLIDGKRETWNSLEDESSNAEPEDTRGEDVIINYFTSGTTGMPKRVIHTAVSYPVGSITTASIVGVRESDLHLNLSATGWAKFAWSSFFSPLLVGATVVGINYEGKLDTRRYLGEVENLGVTSFCAPPTAWRQFITLDLDQFRFERLRSVVSAGEPLNPEVIKIWKDKFNLTIRDFYGQTETTAMVGNFPFLKVKPGSMGKPHPLYDIRLLDDEGKEITKPYEVGHITVKLNPRPIGLFLGYSDEKKNMESFREGYYYTGDKAYFDEEGYFYFVGRGDDVIKTSDYRVGPFEVESALLEHPAVAEAAVVGVPDTVRWQLVKAYIVLKKGYMPSKELAEEIREKMKTLLSPYKVPRIIEFVDELPKTISGKIRRVELRKREEEKRKKGEVGQNEYVF
The following text describes a protein:
Function:
Ubiquitin-protein hydrolase involved in the release of ubiquitin attached via both peptide and isopeptide linkages. Able to cleave 'Lys-48'-linked polyubiquitin chains. Involved in the direct or indirect regulation of AUX/IAA proteins stability. Acts as a linker between the TREX-2 complex and 26S proteasome.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSWCTIESDPGVFTELIQQMQVKGLQVEELYSLDQETLDSLRPVYGLIFLFKWRPGEKDDRLVIKEPNPNLFFASQVINNACATQAILSILLNSPDIDVGPELSNLKEFTKNFPPELKGLAINNSEAIRTAHNSFVRPEPFVPEEQKTATKDDDVYHFISYLPFEGVLYELDGLKEGPVSLGPCPGGQNDSDWLQMVQPVIQERIERYSKNEIRFNLLAVIKNRKELYTVELKECQRRRERLLQQITAAESGPGLPDNKKVEELQRQLAEVNVGIEAATEKIVMEEEKFKNWRTENVRRKHNYIPFLFNFLKILAEKKQLKPLIEKAQQKKVSNPSS
The following text describes a protein:
Function:
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Able to translocate phosphatidylserine, but not phosphatidylcholine (By similarity). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Golgi apparatus membrane. Endosome membrane. Cell membrane. Photoreceptor outer segment membrane. Photoreceptor inner segment membrane. Note=Localizes to the Golgi and endosomes in photoreceptor cells (By similarity). Localizes to disk membranes of rod photoreceptor outer segments (ROS).
Sequence:
MSRATSVGDQLDVPARTIYLNQPHLNKFCDNQISTAKYSVVTFLPRFLYEQIRRAANAFFLFIALLQQIPDVSPTGRYTTLVPLIIILTIAGIKEIVEDFKRHKADNAVNKKKTIVLRNGMWQTIVWKEVAVGDIVKVVNGQYLPADVVLLSSSEPQAMCYVETANLDGETNLKIRQGLSHTADMQTREVLMKLSGTIECEGPNRHLYDFTGNLNLDGKSPVALGPDQILLRGTQLRNTQWGFGIVVYTGHDTKLMQNSTKAPLKRSNVEKVTNVQILVLFGILLVMALVSSVGALYWNGSQGGKNWYIKKMDATSDNFGYNLLTFIILYNNLIPISLLVTLEVVKYTQALFINWDTDMYYLGNDTPAMARTSNLNEELGQVKYLFSDKTGTLTCNIMNFKKCSIAGVTYGHFPELTREPSSDDFSRIPPPPSDSCDFDDPRLLKNIEDHHPTAPCIQEFLTLLAVCHTVVPERDGDSIVYQASSPDEAALVKGARKLGFVFTARTPYSVIIEAMGQEQTFGILNVLEFSSDRKRMSVIVRTPSGQLRLYCKGADNVIFERLSKDSKYMEETLCHLEYFATEGLRTLCVAYADLSERDYEEWLKVYQEASTILKDRAQRLEECYEIIEKNLLLLGATAIEDRLQAGVPETIATLLKAEIKIWVLTGDKQETAINIGYSCRLVSQNMALILLKEDSLDATRAAITQHCADLGSLLGKENDAALIIDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCSQESMLRFPQLYKITQNAEGFNTKVFWGHCINALVHSLILFWFPMKALEHDTVLANGHATDYLFVGNIVYTYVVVTVCLKAGLETTAWTKFSHLAVWGSMLIWLVFFGIYSTIWPTIPIAPDMKGQATMVLSSAHFWLGLFLVPTACLIEDVAWRAAKHTCKKTLLEEVQELEMKSRVMGRAMLRDSNGKRMNERDRLLKRLSRKTPPTLFRGSSLQQSMPHGYAFSQEEHGAVTQEEIVRAYDTTKQKSRKK
The following text describes a protein:
Function:
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Sequence:
MSRTVIVNARLVNEGKEFDADLLIEGGRIARIDSHIAPAAGDTVVDAAGRWLLPGMIDDQVHFREPGLTHKGDIATESGAAVAGGLTSFMDMPNTNPPTLNADALQAKYDAAAGRAWANYGFYMGASNDNLAHIQSLDPKTAPGIKVFMGASTGNMLVDNPETLDAIFRDAPTPIITHCEDTPTIDATMAAYKEKYGDALTAEMHPDIRSREACLKSSQLAVSLARKHNTRLHVLHISTADELMLFEAGPLVDADGKVRKRITAETCIHFLRFDRSDYARLGNLIKCNPAIKDPEDRLALIEALAEDVIDVLATDHAPHTWDEKQKPYAQAPSGLPLVQYALVAALELVHEGKLPITRVVQKFAHAPAQLFDVEQRGFLREGYFADLVLIDNRPFTVKREQVLSKCGWSPFEGTTFRSRIAATWVNGQQVWDGEQLVGSAAGQRLTFDR
The following text describes a protein:
Function:
G protein-coupled receptor for dicarboxylates and amino dicarboxylates. Receptor for itaconate, a metabolite produced by myeloid lineages. In the respiratory epithelium, couples the binding of itaconate to the activation of GNA11 and downstream intracellular Ca(2+) release, leading to mucocilliary clearance of airborne pathogens (By similarity). Receptor for leukotriene E4 (LTE4) produced by mast cells upon allergic inflammation. Binds with high affinity to LTE4 and elicits mucin release from pulmonary epithelium in response to airborne fungi allergens. Regulates mucin-producing goblet cell homeostasis (By similarity). Receptor for alpha-ketoglutarate produced by proximal tubule renal cells upon metabolic alkalosis. In an intrarenal paracrine signaling pathway, binds alpha-ketoglutarate and drives transepithelial salt reabsorption and bicarbonate secretion by SLC26A4/pendrin-positive intercalated cells (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Upon itaconate binding, internalizes via endocytosis in a beta-arrestin dependent manner.
Sequence:
MIETLDSPANDSDFLDYITALENCTDEQISFKMQYLPVIYSIIFLVGFPGNTVAISIYVFKMRPWKSSTIIMLNLALTDLLYLTSLPFLIHYYASGENWIFGDFMCKFIRFGFHFNLYSSILFLTCFSLFRYIVIIHPMSCFSIQKTRWAVVACAGVWVISLVAVMPMTFLITSTTRTNRSACLDLTSSDDLTTIKWYNLILTATTFCLPLLIVTLCYTTIISTLTHGPRTHSCFKQKARRLTILLLLVFYVCFLPFHILRVIRIESRLLSISCSIESHIHEAYIVSRPLAALNTFGNLLLYVVVSNNFQQAFCSAVRCKAIGDLEQAKKDSCSNNP
The following text describes a protein:
Function:
Catalyzes juvenile hormone hydrolysis.
Subcellular Localization:
Endoplasmic reticulum membrane. Microsome membrane; Single-pass membrane protein.
Sequence:
MGLIIKLVLVIITVLTAYQISKLFETPPVPKLENTWWGPRDPSKEDTAIKPFKINVSDEVLKDLQHRLANARPLVPPLEGAQQHYGMNTKLLGKIIDHWRTKYNWREREKFLNQYPQFTARNFVFEVIVPSLPGYGFSEAAVRPGLGPIEMSVVFKNFMKRIGFDKYYIQGGDWGALIVQNMATLFPEHVLGVHSNMCFVNTPLSNLKLLLGSIYPPLIVSKEMESKIYPLSAFYSNILLEMGYMHLQATKPDTVGVALNDSPVGLAAYILEKFTTWTNADWKDLEDGGLTKKYKLDDLLDNVMIYWVSNSITTSVRLYSEAFNKAQLSLGVERIPLKVPSACAVFRNEIAHQPPALLSEKYHNLVHYSEKSDGGHFAAFEVPKILAEDIFVGVEKMIAANSPKK
The following text describes a protein:
Function:
Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.
Subcellular Localization:
Cell junction, adherens junction. Cell membrane; Peripheral membrane protein. Cytoplasm. Photoreceptor inner segment.
Sequence:
MLSFFRRTLGRRSMRRHAEKERLREAQRATTHIPAAGDTRSIITCRVSLLDGSDVSVDLPKKAEGQELFEQIMYHLDLIEKDYFGLQFMDSAQVPHWLDNTKSIKKQVKIGPPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCSFDTAVQLAAYSLQGELGDYDPAEHTPDLVSEFRFIPTQSEEFEFAVLGKWKDFRGQTPAEAETNYLNKAKWLEMYGVDMHMVKARDDNDYQLGLTPTGVLVFEGETKIGLFFWPKITRLDFKKSKLTLVVVEDDEQGKEQEHTFVFKMDHPKACKHLWKCAVEHHAFFRLRSPTHKTSSRSGFIRLGSRFRYSGKTEYQTTKSSKPRRSSSFERRPSKRYSRRTLQMRGQAQRPEFTRFQRDQPGQNKGSQQAWPSNPSVPPSGSALLEIQNLTRSPGAGQGDRCFVGLANSKDLLESNLDDVMTVSQGPAPLPDAITMTFTNPDETVLELGNLASGTEDVTVKRNNLEADAVTTHPIWANMNINVNNQEETVKLPEKLLNNSVESAGPPPVWLTTDIKSNILKAQVEAGHKLTREDLELDDKNKTPEESSARSITVKVNNNLSTPLSWEMPLFRDSQDPKANFFIKNVLSAERESSRSEFPEIPPFITPPEEVVDIKSPTEDLDNLIASLTENLIDLTDVPPKVPSYTTVTPRWLVPQSSAVSNGLLGGEMTTSNDPERLPALTDSLDLTATPTGSVSTGDPGGLPKPKCLLTTEL
The following text describes a protein:
Function:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MADAEDIQPLVCDNGTGMVKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIVSNWDDMEKIWHHTFYNELRVSPDEHPVLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDCLMKILTERGYSFTTSAEREIVRDMKEKLAYVALDYEQELETARSSSAVEKSYELPDGQVITIGAERFRCPEVLFQPSLVGMEAAGIHETTYNSIMKCDVDIRKDLYGNIVLSGGTTMFPGIADRMSKEITALAPSSMKIKVVAPPERKYSVWIGGSILASLSTFQQMWITKGEYDESGPSIVHRKCF
The following text describes a protein:
Function:
Structural component which strengthens the primary cell wall. Forms dendritic structures indicating a propensity for self-assembly through tyrosine cross-linking. Forms intermolecular cross-links exclusively by pulcherosine (three Tyr). Scaffold formation requires an unobstructed C-terminus of EXT3. Required for the correct positioning of the cell plate during cytokinesis in cells of the developing embryo. Extensins contain a characteristic repeat of the pentapeptide Ser-Pro(4). For this particular extensin, a typical repeat of Ser-Pro(3) is found.
Subcellular Localization:
Secreted, primary cell wall.
Sequence:
MGSPMASLVATLLVLTISLTFVSQSTANYFYSSPPPPVKHYTPPVKHYSPPPVYHSPPPPKKHYEYKSPPPPVKHYSPPPVYHSPPPPKKHYVYKSPPPPVKHYSPPPVYHSPPPPKKHYVYKSPPPPVKHYSPPPVYHSPPPPKKHYVYKSPPPPVKHYSPPPVYHSPPPPKKHYVYKSPPPPVKHYSPPPVYHSPPPPKKHYVYKSPPPPVKHYSPPPVYHSPPPPKKHYVYKSPPPPVKHYSPPPVYHSPPPPKKHYVYKSPPPPVKHYSPPPVYHSPPPPKKHYVYKSPPPPVKHYSPPPVYHSPPPPKKHYVYKSPPPPVKHYSPPPVYHSPPPPKKHYVYKSPPPPVKHYSPPPVYHSPPPPKKHYVYKSPPPPVKHYSPPPVYHSPPPPKEKYVYKSPPPPPVHHYSPPHHPYLYKSPPPPYHY
The following text describes a protein:
Function:
Binds oxygen cooperatively with very high affinity (P(50) = 0.013 mmHg at 20 degrees Celsius) because of a fast combination (25 microM(-1)sec(-1)) and a slow dissociation (0.2 sec(-1)) rate.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MGLLSRLRKREPISIYDKIGGHEAIEVVVEDFYVRVLADDQLSAFFSGTNMSRLKGKQVEFFAAALGGPEPYTGAPMKQVHQGRGITMHHFSLVAGHLADALTAAGVPSETITEILGVIAPLAVDVTSGESTTAPV
The following text describes a protein:
Function:
Involved in protein export. Participates in an early event of protein translocation (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MELALQITLIVTSVLVVLLVLLHRAKGGGLSTLFGGGVQSSLSGSTVVEKNLDRLTLFVTGIWLVSIIGVALLIKYR
The following text describes a protein:
Function:
Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the transfer of an acetyl group to the C-3 amino position of UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate (UDP-D-GlcNAc3NA).
Sequence:
MSYYQHPSAIVDDGAQIGSDSRVWHFVHICAGARIGAGVSLGQNVFVGNKVVIGDRCKIQNNVSVYDNVTLEEGVFCGPSMVFTNVYNPRSLIERKDQYRNTLVKKGATLGANCTIVCGVTIGEYAFVGAGAVINKNVPSYALMVGVPARQIGWMSEFGEQLQLNEQGEAVCSHSGARYVLNGKILSKVDV
The following text describes a protein:
Function:
Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSSDEEDGRVEEEEEEEEEEEEETFSKKKKDLQQRRRQGRDDEASEDDDDEEEEDEDAPNEYEKDDFLVDEVEEEEGGEEEEGDDEENRKERKRRKREELELDEDDYDLIAEANPDFRPPIKKGSGPRLKRLKKAGGLGVDAGGEEDGGARRARTQEELQQELFGADEDGEEPVEEERRPEVEEEEEDFSENEMDGFIVDEEFDENGNLVPKRKQKKNKGAERRGVVASSAALQEAQDIFGGVDELLEQYKNREREGEDDVDEGFDDLHVDEDEMEDEEGAPRGRRASKASKQAMRAAQRAFEPSLLEERFMTDRDERIRTTDIPERFQVLEEQYGPMPETEDARREAEWIYQQLFNIKYTILRPEYMNLYDPDLRPNVEEELRNVLVLMHEDKLEIPYIGMYRKEKCRNLLDRLAPPPQGRPKDEEDDESQSRLQKFELLWSVAELDRKWMALRQRKRRLEKAYKDHITPSMERGGEDARQWSRVLQEIQTLLKEATSDAALDDVEARARLLLPEEDPSLATVRHKRPQRASLYAYCKSQGLADVAAKFGSVRQLGANLQKGFVETEVEDHPEPPEAVAGSFAGLAFKKPADVLDGARHMAAVEIAADPAVRAAFREKFMPPVSSEAAARPGGAVVSTKPTPRGMDVIDDYHQYGAVKWLYSKPVREFQDGQWLLVMNAKEEGLIEVTVGLPEEETNQLRTLLSELYLSQNVSKNAQLWNEQRRQILAKAFDEFLVPAMEAEVRATLTQRARRHVVGKCEKSLWKLAARAPFARKKVDLEDVNEDEHACRVLAVCWGPGRPATTIVMLDERGELIDTLYTGSLGSKGIGGPRATERWEEDKRKLEEFIKEHKPHVGVVGGANLRCKNLFDDVNQVIYNIVEVEIDQLAAGLDTLHVFYADESIPLLYEKSKVSETQLSGQPEMVRRAVALGRAIQNPLAALAALCGPGREVALLRMHAMQGLVSQEELWGAVERVMTTITTQVGIDVNTAIHHEWLFAPLQFVPGLGPRKAQALQQALAGRGRLTVRKDLLNFKWVAKQVFINSAGSLRTRATAAAAHAEDMDPLDETRIHPLQYNVATALCKAAWLAEQDLTAEEANEDDLEMAVQEIAERPDLIKKVDLERFAREHEAEHGDLGPTLQLIKAELLEPYAEWRVPYRQPNVDELFSLLTGESDETLQKGQIVQATVRRVMKERIFCALESGLTAFVKFDELSDDGSMAAAEIVDKLAEGQVLTACVIEIDKKEFKVELSCKGSYLRREKHYQKPKFTWSYEDPTVIEEYDRAKKKKEARRQYRPRMIQHPLFKNCNLLEATAMLDTQEIGDVIIRPSSKGPTHLSMTIKFYTDVYAQIDIEEGGKDKADPTSFLKLGSTLKIGDEIFEDLDEVMARYIDPFVDFLRKMLEYRKFKAGTKNEVDELLKREKAQNPQRVAYAISVSQQHAGAFMLSYIRNQNPHHEYISISSKGYRFRHQHFTSPDRLVQYFQKHINDPVVQQEAAPPRRAPASVVPLPLQRPPQGHAQKAGGWDQGAPRPPQPDYHNGHQDWQPSDSSQPYNTTWGSGWSQGQPPPPPPGPPPPPGAPPPPPPGAPQSQSAEWAGHGDWAPGSGYGGQQGYAQYSGGH
The following text describes a protein:
Function:
Involved in the pathway that organizes the prospore membrane (PSM) during sporulation. Mediates the assembly of the DON1 ring structure at the leading edge of PSM during meiosis II. May constitute a physical link between SSP1-containing PSM precursors and the spindle pole body (SPB) and may facilitate the recruitment of other factors that are required to promote spore wall formation.
Subcellular Localization:
Prospore membrane. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Localizes to the leading edge, which cover the ring-shape opening of the PSMs during meiosis II. Colocalizes with DON1 to dots in the cytoplasm and at the SPB. Its localization to the PSMs but not to the SPBs depends on SSP1.
Sequence:
MNHWLAFLNKPESLKEQNSDCDQQGEMRHVTDGTLTKSPESKPFRERRSQTWIDSEVPTSTEKSNVQESISSDIISKLSNRRSRRNRSESWAGSEASSPSGNISTLENATEKNTLKSPNKFLQRGGLPTVGIGSQALSPAGKPSTLGNVSPGKFTTYKVHNSIEVNRFSSTPTKLLTNPHKVAAISNDEHYVVSNESLEENIEVAHLENVFRSSKTPDEEQSEYMKLGEIRLSSSSYGGSISKENSLPKVLDELQSQNEEIKALRQKLEEKDDRIQELEELNSMNDAKLQRIEDLQKEFHNERKAASKRLNIVQDRFRKEIKKIREEKITDFQNKNASKKEKNEVTSAKTKCKAFSQRNILVSELYRKQKQILNLQQENDKFLKDINESNNSIVKLRSEVEILKSNLQLSQDENKKLHDNGSFYEKRLNDVYSYMQNLSLFEKDLGKFILEEMKCGHSPSMFQNGFAKLYPDFQDIKNLENMEQYKQLKGKIELLEKNDRIRLEKIISVFKLINERLHFMQQQHSHKIKYLQKEALTKEQQFRLEKRRWHDILNLKEENFQKLKSELKEKLILSEKIQKNAEDKLNDYMNEHQEIVEKLQNQALIASRWSTQIQESENTHKKITDELAGKQSEILKLEETILSLKEDVFQEKLNLKKLYGDPSTELNFETVGKSFPHITKEKYDSLGLDILTDLTYVQSQNLIKNLLIVLDIPLKTFLKIVPTIVIQLRCELTLLTKFANDLNLKVFGKQLDFKSRRKVAMNEFLNNHDIAEVKHPLEYDLQALFKYFFS
The following text describes a protein:
Function:
Involved in telomere maintenance.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MTLTPMEDKGIIPNFNDFKRQLAELLQSRSTVEDITLLQGFLQLVHSKTQQWRGAEGLPATPDLLDAVWKEIHYPIFKWFQQWRAHLLEAAEGGPQERTYISFRRMNGKLNKIFKIIRQFYNGLVQQLFDRYDFGKLLPAGVIRELNVQSGGELQTLDDSSYFTILCVMSLQRCLLYLGCCHRYKCCCSKLSKRFHISDFDDSMRYFMLAKQIVPSVGETYLQEGLVYVQTGNYGHAAYAFMRGSLSRMPTDAGIPNLESIVADASSGLFAKHQGILKRLRSKESDSNKLINREVLEFYFLALFSSVYAPESWSKQGSDIRHCTEILFEKVRSRYARNVRLILQDVLLFIGGFDLVIKKAKAMGLNRSDTLPSNCTAFLETAFDFFSHVIDSVVLKEWQSFDTWEYLALVRVICVWIKSHSIVTQFAHRHTQFCQSVAHLLNNILAHTEYQQLMDVEHRPKRDYFFQEDIMLKDFSAIGHTLSDFNDVDLFQMENLPDRLAGLVDDKLTAKEEGLLKLHAIVFIGKKFLANNDVNIVWCDESKRFNSLKPDVPLRTCSPPKAKTPPPSTSDYTPAGAKQTKKSKPKRNSRRVQSLSSLEAKLMERKGLRQSVAEGRVYSGCSVPAAPMSFDVAPSAHLYQDRAAGTSATQEAATYYNQGYNGPMQLGSTEILNSRSPSGNNRIAFHPSHQAYMQMIQTPQPQAWPTAYGHNAYYSQPTQHPYPMSSQLAQFQNGPIPFVAGPYAMYMPPPGPGMVVLNNGHPMIPNESPPQQHYP
The following text describes a protein:
Function:
Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of helvolic acid, an antibacterial nortriterpenoid. Protostadienol synthase helA cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol). The synthesis of protostadienol is followed by several steps of monooxygenation, dehydrogenation, and acyl transfer to yield the final helvolic acid. Following the cyclization to the tetracyclic protostadienol by helA, cytochrome P450 monooxygenases helB1-mediated and helB2-mediated oxidation at C-4 and C-16, acyltransferase helD2-dependent acetylation of 16-OH, oxidation of C-21 by cytochrome P450 monooxygenase helB4, and short chain dehydrogenase helC-dependent oxidative decarboxylation yield the fusidane skeleton. This intermediate is further modified in three additional steps mediated by the cytochrome P450 monooxygenase helB3, the acyltransferase helD1, and the 3-ketosteroid 1-dehydrogenase helE to give helvolic acid. Compared with the late stages in the biosynthesis of helvolic acid, enzymes involved in the early stage modifications act in a relatively strict order. The hydroxylation of C-16 by helB1 and subsequent acetylation by helD2 should occur before the helB3-mediated oxidation of C-21. C-4 demethylation in fusidane-type antibiotics proceeds in an unusual manner though it is also achieved by oxidative decarboxylation. The methyl group at C-4 beta position is oxidized by helB1 and subsequently removed by the short chain dehydrogenase helC.
Sequence:
MNTAIITGAAQGVGLCIAEALAQRNYRIVLSDIDTEKGPAAASKLNLTHGEGTAAFFHCDLSNLREIDALLSFTIETMGGFSVLINNAGYLRAPFLALSAQDIQDMITVNLTAPIYATQQAIKYWDGLHQGQAGCVVSVTSSSSFKTYASIAPYGAAKAGAAMFTFAAGAFHPRVRVNAVAPTAIATGFDKNRMRVETDRTGPGYTPEEEMRAMGLKRLQPQEVAEAVVRCVEDKGLYGKVLYLDAVEGIKIHDGYT
The following text describes a protein:
Function:
Ethanolamine-phosphate cytidylyltransferase which catalyzes the second step of phosphatidylethanolamine biosynthesis. Involved in the maintenance of plasma membrane and required for proper sporulation.
Miscellaneous:
MISCELLANEOUS: Present with 4700 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTVNLDPDKVWIDGCFDFTHHGHAGAILQARRTVSKENGKLFCGVHTDEDIQHNKGTPVMNSSERYEHTRSNRWCSEVVEAAPYVTDPNWMDKYQCQYVVHGDDITIDANGEDCYKLVKEMGRFKVVKRTYGVSTTEIIHRILTKKSLPPTHPDYYPTTQELSFYSVAQDAVSKHCYVFQRDLDNVLVNGGYKFDAEDCVYVDGDFDLFHMGDIDQLRKLKMDLHPDKKLIVGITTSDYSSTIMTMKERVLSVLSCKYVDAVIIDADATSMSQYNCEKYHIGTAVLTAAGKFSEYLTKELIVKRVESQREVYIARNQKKGMSI
The following text describes a protein:
Function:
Acts as a transcriptional repressor that allows virus to establish and maintain latency. Prevents both the viral DNA replication and the exit programs. Clamps the two operator OL (operator left made of OL1, OL2 and OL3 sites) and OR (operator right made of OR1, OR2 and OR3 sites) together by binding to them and arranging the intervening DNA in a loop. This step allows repression of lytic pR and pL promoters by binding to OL1, OL2, OR1 and OR2 simultaneously. The binding of cI on OR2 additionally activates the transcription of the cI gene thereby mediating an autoregulatory function to maintain the latent state. Once cI is present in sufficient amount, it can repress its own transcription by binding to OL3 and OR3.
Miscellaneous:
MISCELLANEOUS: Bacterial cells harboring a lysogenic lambda phage are immune to further infection by lambda. The cI repressor protein inhibits the lytic development of any additional infecting phage particles. The region of the genome that codes for the cI repressor protein is known as the immunity region.
Sequence:
MSTKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESVADKMGMGQSGVGALFNGINALNAYNAALLAKILKVSVEEFSPSIAREIYEMYEAVSMQPSLRSEYEYPVFSHVQAGMFSPELRTFTKGDAERWVSTTKKASDSAFWLEVEGNSMTAPTGSKPSFPDGMLILVDPEQAVEPGDFCIARLGGDEFTFKKLIRDSGQVFLQPLNPQYPMIPCNESCSVVGKVIASQWPEETFG
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSKAMLKALKQEKANQDTKRYWYARNRCYDRSADDDRRELSLALSSVPKVEWSYFDVKLRQHQEEDDRFCPLLDGRSWTPSGRALILLLEDTLTSSVELPDGCILVSKRPGLDDFLRDMAKQYELVLCTALQQDHARRVVKQALQCELSSGWFQLQNHGTIQASDSLARLCSDATFQALAVTATSSTTAGDSDHVIVVPKYLPDARHSDDGRLKLLAQVLLDLAKLSSDDWLWGLRHLKVQGVFRSIRNGEQQQRYNLNLGLGSSMSTASHNLALRVALGKPITPLPAGDGAYLPPAPDSGRPTLVLDLDETLVSSYRVSSSEDATLHRVAKRPGVEEFLASMANKCELVLWTASWQAYADAVVDEVLDPAGSGIFSHRLYAQHLVSDSKDLSKLGRRLERVIAVDDSEWRYPASMRQNLLVVPAYMGGHGQEDEEHHLQRVAALITRLVSSARNSVKLSYELCLPSPSQIKTCSSPIVSIRSSLRFMNVFFKAYMNREEKYIWPFAFEQGTIRGDQRDQRTTIATLNFDLVTWFNYSWLNMAEYLMIELHGNLCEGV
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1.
Sequence:
MASYFDEHDCEPLNPEREARNNMLLELARRVRGAWSWAPGGRSLFNRMDFEDLGLVDWEHHLPPPAAKAVVESLPRTVISSAKADLKCPVCLLEFEAEETVIEMPCHHLFHSNCILPWLSKTNSCPLCRHELPTDDDSYEEHKKDKARRQQQQHRLENLHGAMYT
The following text describes a protein:
Function:
Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm. Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1).
Subcellular Localization:
Cell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Synapse, synaptosome.
Sequence:
MKDRTQELRTAKDSDDDDDVAVTVDRDRFMDEFFEQVEEIRGFIDKIAENVEEVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMSEYNATQSDYRERCKGRIQRQLEITGRTTTSEELEDMLESGNPAIFASGIIMDSSISKQALSEIETRHSEIIKLENSIRELHDMFMDMAMLVESQGEMIDRIEYNVEHAVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVILGIVIASTVGGIFA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDKRRLTSDTQDSRLLSFPVVRLERIKNDSGKYQPISEELQKMEQRKMSGLPQRFPVVLLERINIYSGNELSEDLRWKWNGPQMKNKEERRRLSAAGYRLVPYGSGITEMNRERREGLGARKQTGSDTNRKSSTCNGFLARSAHSNQPLVLQKPLAREMNSAPKAQQNQMPQLCTVTGGKLIVTPKLTKHTQPDAEENLHGSQKKRTDISGKYLKPGKAQSTKQTVFPKPFGVINPFVCVKSKRRFGSNGNLLIHQRIHTERPFSCTDCGKCFSHRTILREHRRAHMGKGPFPHSTGGNKIPSGKGNFQRHQGASAKGKPLTCTECGKSFKCKSDLRVHERTHTGEKPYVCTQCGKGFSQKANLNTHSVIHSTERPFSCTECGKCFRLKQCLKSHEKIHTGVKDFVCTECGKSFNRKFELQKHERTHTGEKPYVCTQCGKGFSQKVHLESHSLIHSTEKPFSCAECGKCFRLKQHLKSHEKTHTGVKDFVCTECGKQFIQKYSLRQHLLIHTGEKPFVCNVCGKGHRCKKHLERLSRGRKQSTFYMYQTKISYYR