lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Glycosyltransferase that mediates the glycosylation of glycosylinositol phosphorylceramides (GIPCs), the major sphingolipids in the plasma membrane; acts as a HexN(Ac)-specific GIPC sugar transferase and accepts glucosamine (GlcN) and N-acetylglucosamine (GlcNAc) as the sugar unit. Responsible for the glycosylation of a subgroup of GIPCs found in seeds and pollen that contain GlcNAc and GlcN (GlcN(Ac)). Maybe involved in the maintenance of cell-cell adhesion.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MMEETTDNTGTISSQKNVAASGHNHHHRYKYISNYGVGRRFLFFASCFGFYAFVAATYAWFVFPPHIGRTDHVSSSSLGCREDNEGSWSIGVFYGDSPFSLKPIETRNVWRNESGAWPVTNPVITCASFTNSGLPSNFLADPFLYVQGDTLYLFFETKSPITMQGDIGAAKSIDKGATWEPLGIALDEAWHLSFPFVFNYNGEIYMMPESNEIGQLNLYRAVNFPLSWKLEKVILKKPLVDSTIVHHEGIYWLIGSDHTGFGAKKNGQLEIWYSSSPLGTWKPHKKNPIYNGKRSIGARNGGRAFLYDGSLYRVGQDCGENYGKRIRVSKIEVLSKEEYREVEVPFSLEASRKGKNSWNGVRQHHFDVKQLSSGEFIGLVDGDRVTSGDLFHRVILGYASLAAAISVVILLGFLLGVVNCIVPSTWCMNYYAGKRTDALLNLETAGLFSEKLRRIGSRLNRVPPFLRGFVKPNSSMGKFTLGVIVILGLLLTCVGVRYIYGGSGAVEPYPFKGHLSQFTLATMTYDARLWNLKMYVKRYSRCPSVKEIVVIWNKGPPPDLSELDSAVPVRIRVQKQNSLNNRFEIDPLIKTRAVLELDDDIMMPCDDIEKGFRVWREHPERLVGFYPRFVDQTMTYSAEKFARSHKGYNMILTGAAFMDVRFAFDMYQSDKAKLGRVFVDEQFNCEDILLNFLYANASGSGKAVEYVRPSLVTIDTSKFSGVAISGNTNQHYRKRSKCLRRFSDLYGSLVDRRWEFGGRKDGWDL
The following text describes a protein:
Function:
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAGTTSDLRNGIVIRYNNDLYQVVEFQHVAPGNWRAFVRMKLKSLTTGKVIEDRVRAGAEIDIVRIERRPMQYLYREGDSFIFMDNDTFDQIPVSADLVGDAVRFMKENETVDLVYDAEKDTIIGVELPIFVNLKVVETTVAVRGDTATNVTKPATLETGAVIEVPAFINEGDVLKIDTRTGEYITRV
The following text describes a protein:
Function:
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs. Rev itself is translated from a fully spliced mRNA that readily exits the nucleus. Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1. KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus. In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs. Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface. Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex. Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export. Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import. The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
Miscellaneous:
MISCELLANEOUS: HIV-1 lineages are divided in three main groups, M (for Major), O (for Outlier), and N (for New, or Non-M, Non-O). The vast majority of strains found worldwide belong to the group M. Group O seems to be endemic to and largely confined to Cameroon and neighboring countries in West Central Africa, where these viruses represent a small minority of HIV-1 strains. The group N is represented by a limited number of isolates from Cameroonian persons. The group M is further subdivided in 9 clades or subtypes (A to D, F to H, J and K).
Subcellular Localization:
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Domain:
The RNA-binding motif binds to the RRE, a 240 bp stem-and-loop structure present in incompletely spliced viral pre-mRNAs. This region also contains the NLS which mediates nuclear localization via KPNB1 binding and, when the N-terminal sequence is present, nucleolar targeting. These overlapping functions prevent Rev bound to RRE from undesirable return to the nucleus. When Rev binds the RRE, the NLS becomes masked while the NES remains accessible. The leucine-rich NES mediates binding to human XPO1.
Sequence:
MAGRSGDSDEDLLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTVLESGAKE
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
SGAAAAQTAAASSLHQASNHTFYPWMAIAGESTADPIKSKIRSDLTQYGGISTDMGKRYSESLAGSLLPDWLGTNGLRRRGRQTYTR
The following text describes a protein:
Function:
Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin/hair pigmentation. In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin/hair pigmentation. Also catalyzes import of cysteine into lysosomes in non-pigmented cells, regulating lysosomal cystine and cysteine storage, which is essnetial for redox homeostasis.
Subcellular Localization:
Melanosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Sequence:
MVPGSPAAGAGPAPRALSLAARLSYAVGHFLNDLCASMWFTYLLLYLHSVRAYSSRGAGLLLLLGQVADGLCTPLVGYEADRAAGRCARCGPRKAWHLVGTVCVLLSFPFIFSPCLGCGAATPEWAALLYYGPFIVVFQFGWAATQIAHLSLIPELVTSDHEKVELTALRYAFTVVANITVFGAAWLLLRLQGSAREGPPDEAGDHLGVQDVPVFRTLSLCVVGVGAVFSLLFHLGTRERRRPPAQEPDERSPLLAPATARPLLLWKHWLREPSFYQVGLLYMSTRLIVNLSQTYIAMYLTYSLNLPKKFIATIPLVMYVSGFCSSFLMKPVNKCIGRNMTYFVGLLVILAFAAWVVLVDELGMAVYVAAVLLGGGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFSDKVANGLAVMVIQSLHPCSLELCCRACVGFYHWVMVAVTGGVGVAATLSLCSLLVWPIRLRSWDPGAQP
The following text describes a protein:
Function:
Catalyzes the decarboxylation of oxaloacetate into pyruvate with high efficiency. Is also able to decarboxylate 3-methyloxaloacetate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate.
Sequence:
MHRASHHELRAMFRALLDSSRCYHTASVFDPMSARIAADLGFECGILGGSVASLQVLAAPDFALITLSEFVEQATRIGRVARLPVIADADHGYGNALNVMRTVVELERAGIAALTIEDTLLPAQFGRKSTDLICVEEGVGKIRAALEARVDPALTIIARTNAELIDVDAVIQRTLAYQEAGADGICLVGVRDFAHLEAIAEHLHIPLMLVTYGNPQLRDDARLARLGVRVVVNGHAAYFAAIKATYDCLREERGAVASDLTASELSKKYTFPEEYQAWARDYMEVKE
The following text describes a protein:
Function:
May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPRGFLVKRSKKGCGTYRVPCGASSPQQSVPFLPAPEPPSPHIPSSPPDSVPAEKEGTKVAQSYSKVSSDTSPIRQDGTGSWSQLPYSPVQPTGLEMKTTFFKRYPSSPATGESFPVAASLVSMEKLLINHNPFLTPEGKLHGNLCARDAPRFTKCPPKKSKVTRKLNFTDEVTTSPVLGLKIKAEDPECKSRSPLGKRPPLGEFICQLCKEQYPDPFALAQHKCSRIVRVEYRCPECDKIFSCPANLASHRRWHKPRAPGADGGAGGKKPHSELEGKENSSAPRSVPLSLLESPVQHQQAADSSQRSDQHHLPADSSPFLSRAAGTGAPLPRAGSDDGEEEAFDCPYCHKRFRRQAYLRKHLLSHQPYSPMERGPLTYPCTLCGVHFPSMDIRDKHRLWHAVREELLIPLEDSLMAEGGQQIFPCERCPTAFFSSPGLTLHMSKCHSAGSGQDLPMGPPGC
The following text describes a protein:
Function:
Probable transcription factor which regulates lipid catabolism, storage, and secretion, probably by modulating genes involved in fatty acid desaturation and beta-oxidation, and lipoprotein assembly and secretion. Involved in reproduction, perhaps indirectly.
Subcellular Localization:
Nucleus.
Sequence:
MLKMEQSAPPRYEEDWADVYEFIERDSSRKNVPAIEAIERRLAFSPLITPNPGAKQFAPIHVPGREPPRMLLPPTPHFQAPFSPHPPPVQQVPSYSPPHAPPSYETYPEVYYPPHIICNPYDVPTTSDRNPPYYTEVTTVSAVTLHSMTPPTHKIETPPSSPENSFGPLASQLPAIKMEIPMHPLPHNGELDSTRSSPSSTTSSERSPLQRKSRIESNKRNPTDKKFVVHACTYPGCFKKYSKSSHLKAHERTHSGEKPFVCKWQNCSWKFARSDELTRHMRKHTGDKPFRCSLCDRNFARSDHLSLHMKRHSTI
The following text describes a protein:
Function:
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDPNSLASSFVQHYYSNFCNQATRANVLSLYSPTAQMIFNGTHCRGIEAIQQQLERMSFKTVNIPNPTISAMDLGGRYLVKVSGLLSIDDSNQPIGFAHVFVLGSNNGSFYIEGEIFSFAIN
The following text describes a protein:
Function:
The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
Subcellular Localization:
Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Golgi apparatus.
Sequence:
MASLQLLRGPFLCVLLWAFCVPGARAQEHGAGVHHGSVGLDKSTVHDQEHIMEHLEGVINQPEAEMSPQELQLHYFKMHDYDGNSLLDGLELSTAITHVHKEEGSEQVPPMSEDELISIIDGVLRDDDKNNDGYIDYAEFAKSLQ
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Sequence:
MPLSIIHFPHPTLRHVSRPIVRVDAKLKSMADEMLDLMYEFDGVGLAANQVDLPIRMFVANPTGKRDEGESWVILNPEIDRPKGNDTAQEGCLSVPGLYGQVKRPKTVRLRGFDLQGNEINQVLDGFMARVVQHEVDHLDGIMFFDRIGEEGLRDLEGHLEEFKTDYESKQGTGSIADEATLAQQRAEWEAMYTGGTTSNG
The following text describes a protein:
Function:
Together with COR28, involved in central circadian clock regulation and in flowering promotion, by binding to the chromatin of clock-associated evening genes TOC1, PRR5, ELF4 and cold-responsive genes in order to repress their transcription. Negative regulator of freezing tolerance.
Subcellular Localization:
Nucleus.
Sequence:
MVGDYRGRFSSRRFSDDSDDSSDDASSVEGETTSSMYSAGKEYMETEWTNEKHSLYLKSMEASFVDQLYNSLGALGKNENVSESTRFGSGRKPSQEQFKVLHDGFWQKINVKQPEHRINGRHGGNSHEFLRSPWIKHYKPLVKTQIPVTDEPENQVVSSSNGKKGICSSGSASSLKQLSSHSRDHDQISVGEAEVSDQNFVNEGIKGENGSSKKMKTVMMSESSSTDQVVPLNKLLQHDVNLKSVS
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Regulates rhizobacterium B.cereus AR156-induced systemic resistance (ISR) to P.syringae pv. tomato DC3000, probably by activating the jasmonic acid (JA)- signaling pathway.
Subcellular Localization:
Nucleus.
Sequence:
MAVDLMRFPKIDDQTAIQEAASQGLQSMEHLIRVLSNRPEQQHNVDCSEITDFTVSKFKTVISLLNRTGHARFRRGPVHSTSSAASQKLQSQIVKNTQPEAPIVRTTTNHPQIVPPPSSVTLDFSKPSIFGTKAKSAELEFSKENFSVSLNSSFMSSAITGDGSVSNGKIFLASAPLQPVNSSGKPPLAGHPYRKRCLEHEHSESFSGKVSGSAYGKCHCKKSRKNRMKRTVRVPAISAKIADIPPDEYSWRKYGQKPIKGSPHPRGYYKCSTFRGCPARKHVERALDDPAMLIVTYEGEHRHNQSAMQENISSSGINDLVFASA
The following text describes a protein:
Function:
Catalyzes oxidation of malate to oxaloacetate in the citric acid cycle. Donates electrons to quinones of the electron transfer chain.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MSMEFDAVIIGGGVSGCATFYTLSEYSSLKRVAIVEKCSKLAQISSSAKANSQTIHDGSIETNYTPEKAKKVRLSAYKTRQYALNKGLQNEVIFETQKMAIGVGDEECEFMKKRYESFKEIFVGLEEFDKQKIKELEPNVILGANGIDRHENIIGHGYRKDWSTMNFAKLSENFVEEALKLKPNNQVFLNFKVKKIEKRNDTYAVISEDAEEVYAKFVLVNAGSYALPLAQSMGYGLDLGCLPVAGSFYFVPDLLRGKVYTVQNPKLPFAAVHGDPDAVIKGKTRIGPTALTMPKLERNKCWLKGISLELLKMDLNKDVFKIAFDLMSDKEIRNYVFKNMVFELPIIGKRKFLKDAQKIIPSLSLEDLEYAHGFGEVRPQVLDRTKRKLELGEKKICTHKGITFNMTPSPGATSCLQNALVDSQEIAAYLGESFELERFYKDLSPEELEN
The following text describes a protein:
Function:
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSMDVNAVVIYLTIVIVEQKHALLTKIALVREVVMGAPLRAVLKQLVTRTVSPDLGKPIALVHHPNESFFLVPQAYKVIVIFPIRFSDSIDTVLATSFLQLADFELKEFLASDESKSDDSEKGDDTEKSAKRKKKQDTYPVLLQSGKGS
The following text describes a protein:
Function:
Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
Sequence:
MATEFTPSVYSLVSTPLPSNSRPSATLDEQAETEDLISQLFDLTADPNALVSQHGKIYSGLRKQEHTQFLASTFFQLPGKFVSLDASRPWLIFWTVHSLDLLGVALDQGTKDRVVSTLLHFLSPMGGFAGGPANSQIPHLLPTYASVCSLAITGNDGPTGGWKDLADARQSLYEFFMRCKRPDGGFVVCEGGEVDVRGTYCLLVVATLLDIITPELLHNVDKFVSACQTYEGGFACASFPFPSVVPSTSALPTSEPSCRVSMAEAHGGYTSCSLNSHFLLTSVPLPSFPSSIDASAALRWTVLQQGEAIEGGGFRGRTNKLVDGCYSWWVGGGAPVAEELVRREKSKKVKKSRVELIEEEEKEGDWEDVPPIPPTFNRVALQEFTLVAAQQDPGSTGGLRDKPGKRPDQYHTCNNLSGLSIAQHKMSHSPSAVSSNRLKFDASKGLPAIEPVAPGGGWKNEDERRNARREIWANALGWIEEEGGEIIVGGRDNRVNTTTPVFNILGLRLKPFINYFYCQEN
The following text describes a protein:
Function:
Hydrolase highly specific for thiamine triphosphate (ThTP).
Subcellular Localization:
Cytoplasm.
Sequence:
MFTDNTINTYLKPACIMESGIHAKYGAAATAKLRNRFSEQAMACRDLSRGHCEVERKFRAPCDIEDRLVRIGAVLGSRTQFTDRYYDTQDNVLALNDHWLRIRGGASDHWELKYRKHNDTPSNDSAVTIYNEETGEANILTIVKKLLPERSPVGEAVTLKDFVSEGLLREFACIQTWRSSYKTSGRSVVDLDQTDWGYRVAEIEVLLQEADCDAQGKDAMEKATEEISRLAAQLDGKPLFINPKHAARELGRAQFETRIPCPRTAFRGRGSIHDLVDTCAIDPQR
The following text describes a protein:
Function:
Involved in defense response to powdery meldew fungus; Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MAWSCRAVLAKPMGLILTALLFFPAALSAPTPPLISLPTEDDGLSYGFHDHKCPALLNNVSTAVRNARRSDPGITAGLLRLTFNDCFPQGCDASILLTGPNSEQDILPQNAGLQQGALDLIESIRAKVHRACGPTVSCADITNLATREAVLQSGLPRYEVPLGRRDSIAPARRQDVEALPRPDFDVHQLVQSFRSRGLDETDLVALSGAHTIGEAGCGSFENRFSSEEINTNGFVKRLLDNCTVNADRRQDLDVTTPMKFDNKYFTNLYRGIGVLSSDMALLLDVNTRSKVKDFAGDQEWFFRQFSNSMSKLAHRQGAKGNNAEIRNHCFERNNGGPFVGMGFKASA
The following text describes a protein:
Function:
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
MTAPPEQRQKPDPSAATKGFFRHLGLFEMLPESADKKDFFSDLIRSILKVDRVEPGRVTCTLTVRSAVTNPYNTLHGGAVAAVAEMVSLACAKTAAGDKDFFLGESSTAYLSAARLNEDVEVNASILRQGRNVVVTSVDFRTKKTGKLLFTSRSTFYIMPVSSL
The following text describes a protein:
Function:
Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair.
Subcellular Localization:
Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MFRRPVLQVLRQFVRHESETASSLVLERSLNRVHLLGRVGQDPVLRQVEGKNPVTIFSLATNEMWRSGDSEVYQLGDISQKTTWHRISVFRPGLRDVAYQYVKKGSRIYLEGKIDYGEYMDKNNVRRQATTIIADNIIFLSDQTKEKE
The following text describes a protein:
Function:
Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
Subcellular Localization:
Preautophagosomal structure membrane; Multi-pass membrane protein.
Sequence:
MSQGQLYTTDYLLMETDNEADDNNGSGVDDVDEDNELPPTDNIVIIDSVDRDNYSRWNHLSDLDEFFTRIYAYVQRHGFLAMALQDIFQIIILWYVVIFPTFICVGVNYDVLFQDHFNITYKVIINDAIRPWKEVKERFNPFLILFLITSSFYLVFKTFKGLYNISKYWEIRRFFTYALEIQPSELANKKWHEVQTLLMLVQQKLHMCVHKNELTELDIYHRILRFKNYMVALVNKSVLPMKFNLPFWGEIVYFTSGLKYNYEMILFWGPGAPFANSWHLRKEYKSYNKRKELATILSRRIFIAGIINLLLAPVIFVWTLLYLVISHFALFRTDPGQVSLRSWSLYGRQYLRHFNELDHDFNARLNRGYRAAVKYMGLFWSPVMAAIAQFIVVISSGFLIFFVICAVTDEDTLAVQGVIKIMTLLGLVVSVVRHLIPDENMVRNPETLMTLIQSQTHYMNDSWKGQAHTRKVMDEFSQLFQYKLVYLINEMVSAIVCPFILIFSLRPNSLQIVDFLRNFTVTLEGIGDVCSFAQMDIKKHGHPEWNAPGNLELESPENKTLRAEFGKTELSLMNFKLTNPDWKVPDFENAFINNIRQNVNSMRRERGLLTGVHVLEDEDPMMTSSQALSAVGQPNGFQSVMLSSIAPASEYSSMFVTDGGFSHHHVRPTDLHLPVTLNSQGQGQQLQRNQLSGRDLFSSNVIASGAGVSGADGVSGGG
The following text describes a protein:
Function:
Involved in 5'-end processing of mitochondrial COB, 15S rRNA, and RPM1 transcript. May also have a role in 3'-end processing of the COB pre-mRNA.
Subcellular Localization:
Mitochondrion.
Sequence:
MVSYGSHSSEVSKVLKTPKFVLRYGNVSSKQRFALKRKINYKLRESKYQEYLNEYNTFVLYDWENSGAGSLVDSSYNLPSLWKEFITEGISKGAINDKLPTVFMKRKLTNSALGHCLGLDFLTDPSESEHEYRCMFQTVQDIPSLSQLILFNSMPNVPVRLKLHTIGININFGCKRSLISNGGDQDTEMSEAVSYIQPLLEESSRMYRNLNYWKLLKIARNNKKDEPLDQSTRIKSQVKLLLSQLATNRITSPSVTDHGGHNWLIFTRRRL
The following text describes a protein:
Function:
Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (By similarity). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (By similarity).
Domain:
The protein goes through several conformation states during the reaction cycle, giving rise to hysteresis. In the initial state, the ligand-free protein is in an inactive conformation (E*). Substrate binding triggers a change to the active conformation (E). UDP-xylose binding triggers the transition to a distinct, inhibited conformation. The presence of an intrinsically disordered C-terminus promotes a more dynamic protein structure and favors a conformation with high affinity for UPD-xylose; The allosteric switch region moves by about 5 Angstroms when UDP-xylose is bound, and occupies part of the UDP-glucose binding site. At the same time it promotes domain movements that disrupt the active hexameric ring structure and lead to the formation of a horseshoe-shaped, inactive hexamer.
Sequence:
MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDINESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSHGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLTANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPGVSKDDQVARLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVSSKRIPYAPSGEIPKFSLQDMPNKKPRV
The following text describes a protein:
Function:
Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin.
Sequence:
MSHIGPAIECSPSAIPTPAVFGAEILSLEASWVRNFTLDVPGNFNYNHGAQSVQNVDFCNVTVTYSHPGYDDRITVETWLPRHWNQRLQATGGGGWRAGRFVLSQFFMGGAIGEGYATTTTDAGLGDTMPDAWALKSTGNVNLEYLHNLGYRSLNDEAIIAKDLVRSFYGIPPAYSYWSGCSQGGRQGLMLAQRYPHAYDGIVASAPAQSWPEFVTAVYYPLLAPLWAGEPSPLSCELEFLTAEAVKHCDSQDGIVDGIISDPNNCDFDPFSAVNKTFSCTATGKPMRLTRAAAITAKAAWTGPRTVAGDFLWYGVNPGSDITGLGVAPGQNLTTSPDEWLSLFLVKNQSFDATQLSHEEYGTLFHFSVKEYTDVMAANDPDLTAFKKAGGKLLTYHGMADESIPTKGTEHYYRAVSQLIPDVQDFYRYFESPGLAHCAGGRGGQPTTAFDALRKWVENGTAPEFLPVRVNGTDGEHNRILCPYPAKPIQQGGNASGVGSFRCVH
The following text describes a protein:
Function:
Plays a role in photosynthetic sucrose synthesis by catalyzing the rate-limiting step of sucrose biosynthesis from UDP-glucose and fructose- 6-phosphate (By similarity). Involved in the regulation of carbon partitioning in the leaves of plants (By similarity). May regulate the synthesis of sucrose and therefore play a major role as a limiting factor in the export of photoassimilates out of the leaf (By similarity). Plays a role for sucrose availability that is essential for plant growth and fiber elongation (By similarity).
Sequence:
MARNDWINSYLEAILDVGTSKKKRFESNSKIVQKLGDINSKDHQEKVFGDMNGKDHQEKVFSPIKYFVEEVVNSFDESDLYKTWIKVIATRNTRERSNRLENICWRIWHLARKKKQIVWDDGVRLSKRRIEREQGRNDAEEDLLSELSEGEKDKNDGEKEKSEVVTTLEPPRDHMPRIRSEMQIWSEDDKSSRNLYIVLISMHGLVRGENMELGRDSDTGGQVKYVVELARALANTEGVHRVDLLTRQISSPEVDYSYGEPVEMLSCPPEGSDSCGSYIIRIPCGSRDKYIPKESLWPHIPEFVDGALNHIVSIARSLGEQVNGGKPIWPYVIHGHYADAGEVAAHLAGALNVPMVLTGHSLGRNKFEQLLQQGRITREDIDRTYKIMRRIEAEEQSLDAAEMVVTSTRQEIDAQWGLYDGFDIKLERKLRVRRRRGVSCLGRYMPRMVVIPPGMDFSYVLTQDSQEPDGDLKSLIGPDRNQIKKPVPPIWSEIMRFFSNPHKPTILALSRPDHKKNVTTLVKAFGECQPLRELANLVLILGNRDDIEEMPNSSSVVLMNVLKLIDQYDLYGQVAYPKHHKQSEVPDIYRLAAKTKGVFINPALVEPFGLTLIEAAAYGLPIVATRNGGPVDIVKALNNGLLVDPHDQQAISDALLKLVANKHLWAECRKNGLKNIHRFSWPEHCRNYLSHVEHCRNRHPTSSLDIMKVPEELTSDSLRDVDDISLRFSTEGDFTLNGELDAGTRQKKLVDAISQMNSMKGCSAAIYSPGRRQMLFVVAVDSYDDNGNIKANLNEIIKNMIKAADLTSGKGKIGFVLASGSSLQEVVDITQKNLINLEDFDAIVCNSGSEIYYPWRDMMVDADYETHVEYKWPGESIRSVILRLICTEPAAEDDITEYASSCSTRCYAISVKQGVKTRRVDDLRQRLRMRGLRCNIVYTHAATRLNVIPLCASRIQALRYLSIRWGIDMSKTVFFLGEKGDTDYEDLLGGLHKTIILKGVVGSDSEKLLRSEENFKREDAVPQESPNISYVKENGGSQEIMSTLEAYGIK
The following text describes a protein:
Function:
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDFQHAQLDWDENGQPLSRAFGDVYFSRHSGLNETRHVFLATNRLAERFAALGDGEVLCIGETGFGTGLNFLCAWQLFERVAPAGARLEFVSVEKFPLAAADLRRALALWPELAPWSEALLGQYLAVHPGFQRLAFAGGRVGLTLLLGDALECLPQLDARVDAWFLDGFAPAKNPDMWSPVLFAELARLSAPQATLGTFTSAGFVRRGLVEAGFAMQRVPGYGQKREMLSGTYQGPPANAGKPWYARPAPHAGRRAALVVGGGLAGCASAASLAARGWQVTLIERHPGLAREASGNPQGVLYLKLSAHGTPLSRLVLSGFGHTRRLLERLRRGHDWDACGVLQLAFDAKEAQRQAQLAAAFPADLLHGLEREQAERLAGVALPAGGLFYPEAGWVHPPALCQALAATPGITLLSGRAVRLRREGDDWCAYAGDECLARAPLAILATAADIRDFPPAAELPLKRIRGQVTRLPATPQSRALRTVVCAEGYVAPPRGDEHTLGASFDFKSEDLAPTLAEHQGNLELLREISPDLLQRLGADDLPLERLEGRAAFRCTSPDYLPLVGPLAERAAFDEAYAVLARDARQVPERACPWLPGLYLNSGHGSRGLISAPLSGELLAAWICGEPLPLPRAVAEACHPNRFLLRDLVRGQRG
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MLKETVGTAMKRLRREFYMILSGLSADEEQAMGDLREIAECMEKNGYGKECVEVYKSVRRLVVGASLRRHGFDAKKRTTTWLTSDWDSVEKKIISWMGFFRVAVKTIFSGERFRSDYIFNFSDALKESCFSKTIGDIAENFLAFPCIFAGAVKSMKINMVSPAVICRFLDLHSTLSDLLGDIKTIFSYTSTYAVQKKATASINIVGKLIRSLLSQFESSIMKNTLPSAMSVVASGGIHPVTRYVMNYVVSIGDCITALSDIYINYPPLPETFFQSTTTGNSNVSSRLAWILLILLCKLDQKSDLYKNPSLSYLFLSNNLQFVVQKVRGSMFRYLLGERWLLENEKKAMHYMEKYVTGAWKKVIVAALPKFPATVELEAGKKMIGDFNLAFEEACGAQSGWVVEDISMREKVKNMIRRNIVEPYRGFCDVWFSTGSVQMSYFPVDIGIFIDMVI