lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the oleanane-type triterpene saponins (e.g. saponarioside A and saponarioside B) biosynthetic pathway, leading to the production of natural products with detergent properties used as traditional sources of soap. An oxidoreductase that facilitates the oxidation of the methyl group to a carboxyl group at the C-28 position of beta-amyrin, resulting in the formation of oleanolic acid. Catalyzes also the subsequent oxidation of the methyl group to a< carboxyl group at the C-16 alpha position of oleanolic acid, resulting in the formation of echinocystic acid.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MELITLLSALLVLAIVSLSTFFVLYYNTPTKDGKTLPPGRMGWPFIGESYDFFAAGWKGKPESFIFDRLKKFAKGNLNGQFRTSLFGNKSIVVAGAAANKLLFSNEKKLVTMWWPPSIDKAFPSTAQLSANEEALLMRKFFPSFLIRREALQRYIPIMDDCTRRHFATGAWGPSDKIEAFNVTQDYTFWVACRVFMSIDAQEDPETVDSLFRHFNVLKAGIYSMHIDLPWTNFHHAMKASHAIRSAVEQIAKKRRAELAEGKAFPTQDMLSYMLETPITSAEDSKDGKAKYLNDADIGTKILGLLVGGHDTSSTVIAFFFKFMAENPHVYEAIYKEQMEVAATKAPGELLNWDDLQKMKYSWCAICEVMRLTPPVQGAFRQAITDFTHNGYLIPKGWKIYWSTHSTHRNPEIFPQPEKFDPTRFEGNGPPAFSFVPFGGGPRMCPGKEYARLQVLTFVHHIVTKFKWEQILPNEKIIVSPMPYPEKNLPLRMIARSESATLA
The following text describes a protein:
Function:
Transcriptional repressor. May play a role in early development as a Wnt/beta-catenin effector, hence controlling pluripotency and preimplantation development of embryonic stem cells. May promote adipogenesis in mesenchymal stem cells, possibly by inhibiting the expression of the antiadipogenic factor NR2F2. May inhibit osteoblastogenic differentiation.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Note=Specifically localizes to the nucleoli of oocytes and preimplantation embryos.
Sequence:
MLAWQDGGAKAAPSHHKISFSVLDILDPQKFTRAALPAVRPAPREARKSLAEVEAGKDASSRDPVRQLETPDAAGPGAGQASPLEGSEAEEEEDAEDPRRPRLRERAARLLPGLARSPDAPAGALASGEPCEDGGGGPVRSPPGSPGSPRPRRRRLEPNCAKPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADGAAQVGGGAPQPGAAGGGGGGGSGGSPGPPGTGALHFQTFPSYSAANVLFPSAASFPLTAAAPGSPFAPFLGPSYLTPFYAPRL
The following text describes a protein:
Function:
Promotes matrix assembly and cell adhesiveness.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MKFSSLYCFLLLLIFQTDFGQNEETSRRQRRKMYHRRLRKSSLSTHRSVRQPGIQQMKTVTPAAKLPIINLDYSIEENFESFLSVPGVESSYNVLPGKKGHCLANGMIMYNKAVWSPEPCTTCLCLNGKVLCDETKCHPQMCPQTIIPEGECCPVCSDTVASYLLLSGTALNDRTEFSGDSSEQREPTNLPHKQQSPPWEEMNRALRKEELQLEEDEEEVKQDENREQKKKTFRPGDWGRPINEGQSREGKAQRPEEEGRQAHQHRNPARENEEDDDEEEEDDDDEEEDDDDEDETIRGDTFRMPPRLPIPATPRGIPSLPSMCSLSYKTISCISADLTQIPPLTAPEITSLELIDNSITSIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKFLKNLMRLNMDGNNLVTIPSELPSTLEELKINENKLQVIDEESLSDLNQLVTLELEGNNLSETNVNSLAFKPLKSLSYLRLGRNKFRIIPQGLPASIEELYLENNQIEEITEISFNHTRKINVIGLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLVHLVLIGNQIERIPGYVFGHMEPGLEYLYLSFNKLVDDGIDRVSFYGAYHSLRELFLDHNELKSIPPGVQEMKALHFLRLNNNKIRNILPEQICNAEEDDDSNLQHLHLGNNYIKTREIPSYAFSCIRSYSSIVLKPQNIK
The following text describes a protein:
Function:
Ca(+)/H(+) antiporter that extrudes calcium in exchange for external protons. Does not transport sodium or potassium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYMGRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLLVAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSIGISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVAYISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAVGSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEGATLLAAYVIMAIGFFLL
The following text describes a protein:
Function:
Serine/threonine-protein kinase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with PPM1K, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (Probable). Phosphorylates and inactivates mitochondrial BCKDH complex a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Associates with the E2 component of BCKDH complex and phosphorylates BCKDHA on Ser-333, leading to conformational changes that interrupt substrate channeling between E1 and E2 and inactivates the BCKDH complex (Probable). phosphorylates ACLY on Ser-455 in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and glucogenesis, respectively (Probable). Recognizes phosphosites having SxxE/D canonical motif (By similarity).
Subcellular Localization:
Mitochondrion matrix. Mitochondrion. Note=Detected in the cytosolic compartment of liver cells.
Sequence:
MILTSVLGSGPRSGSSLWPLLGSSLSLRVRSTSATDTHHVELARERSKTVTSFYNQSAIDVVAEKPSVRLTPTMMLYSGRSQDGSHLLKSGRYLQQELPVRIAHRIKGFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGGQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI
The following text describes a protein:
Function:
Receptor for netrin unc-6 required for asymmetric axon formation, axon guidance and cell migrations. Required during axon formation, in response to unc-6, to initiate, maintain and orient asymmetric neuronal growth, and may signal via phosphoinositide 3-kinase (PI3K). Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in dendritic morphogenesis; may act by localizing unc-6 at the tips of growing dendrites for interaction with unc-5 on the apposing branch to induce mutual repulsion. Involved in the ventral-dorsal and anterior-posterior migration of gonadal distal tip cells (DTCs) along the body. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Positively modulates a TGF-beta-like signaling pathway, independent of its role in unc-6 mediated axon guidance, in association with RGM drag-1. Mediates attraction of muscle plasma membrane extensions, known as muscle arms, towards the secreted madd-4 guidance cue, enhanced by interaction with the coreceptor eva-1.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
Fibronectin type-III 6 motif is essential for the role of unc-40 in a TGF-beta-like signaling pathway.
Sequence:
MILRHFGFILIILTVYLSSTHATTRKHHRRSIDNDARNLGFQFVMEPRRNVTVMESSSHLLECSYVLAHERLVHDVRIEWKRDGVLLSERTSSRIKVMSNGSLWIESVSSAEEGTYQCAVHVTTKSDQTSDTWTFLSRKATLRLADLAKFELQAIDRTLAKGQPTAFHCLINSKPTPTAVWLHNDEPIVNGGEYHILPVSNTLEISSTQSRHEGTYRCTVEGAGKRRSSQTARLTVTTETVSNELVFITTPRLQVVEQGDEFLLECLVASLIRPQVRWLKDSRQIIVDGVRIRRVGVSSILVSRASIEDTGLYTCRASNNDDSIDRAVSVEVRAPPRITTRPTTKVAVETADVELECGTAAARPEARVNWYKNGEAIIGSEYFVIEPNRLRILGVVRADQAIYQCIAENDVGSEQASAQLLVDAPDSSSVAASSGVPMTSSAPLGLRSTSSGSRFINVEWDPPVQRNGNIMRYHIFYKDNLIDRERMINSSSTSATLTSLQPSTMYLIRVTAENEAGMGKFSDSLKVTTNKEQAVPGKVASLTTTATGPETIDIRWSPPSGGQPALRYKIFYSHDPLEKNEKETLITTSTTHYTLHGMDKYTGYQIRIEAEGSNGSGLSSDTVKVRTQSDEPSAPPVNIQAEADSSTSVRVSWDEPEEESVNGEITGYRLKYKTKARGAKGNTLVIDATAREYTMGNLEPNTQYLIRMAVVNHNGTGPFSDWVSIDTPGQDKEERTLGAPREIRPHAGIDYILVSWLPPADEQNLVRGYQIGWGLSVPDTETIRVTASTTQYKIARLHSERDYVISLRAFNNLGSGFPIYETVRTLSRETPSHFNEDSDSDDSDVGSSESTPVGVRAEAISATSIRVMWTESDETAFNTQYTVRYSTAVDGNQHRYVNSTETWATVEGLRPATEYEFAVRAVASNGQLSTWSMATRNRTLAAPPSSAPRDLTVLPAESGDPHSSSLHWQPPKYSNGEIEEYLVFYTDRASLADKDWTINYVAGDKLSHQVSNLLPKANYFFKIQARNEKGHGPFSSVVGYTPSGGAILSGKDRHNARGHGSAASGDTVSLVDQLQSLLHSNPLYLILLAAFALILILTLILIIMCCWKRSSGGGRKNGYQSGKKTSAGAGSGGGIGGLGGPPNDLWINGTGSHMRAGASDYMVDGLATAHLTAADIESPTPRYHHLQGQGTLTRSYHQSSQSLEGRQRTPQVVYTGTGRHQPIQRIDFESPYGSSSAIGSASTPPLPMQAPPSGPPTVIDGYRTLRGTPPNSSAANALRSFTQLAGATPPPPHSAASSSSRPTIIAAGGRQVPVGRATAQPRVNVANIYSPFASCSASSDAGESDKKSGECMEMRETTPIKSNTAGSSNGEKMNTNMNPSHSAEDLNAHLENLDTMLDDLQQLQHNLHFETSMDK
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MKPHQIKPICISSLLFFLLLFSHYSTAVEAQEVGKYNEINYIHTYSFFLLFFFVEKEKNLINHMHVYIVHIAEDEREFDYLQGSRKGPKQWGEMKKEWAACKNGVMQSPIDLSSQRVKLIPNLGKLNTTYKPCNATVKNRGHDISLTRDVKSMTDQKAKRNMGMIDPRKIKIGGKNYYRYMGSLTVPPCTEVVIWTIDRKIRTVSTDQVKLFRFAVHDYAEMNAGPVQPLNLREIQVYDRNARSTNNQQRV
The following text describes a protein:
Function:
Protein O-mannosyltransferase that catalyzes the transfer of a single mannose residue from a polyprenol phospho-mannosyl lipidic donor to the hydroxyl group of selected serine and threonine residues in acceptor proteins.
Subcellular Localization:
Cell membrane. Endomembrane system; Multi-pass membrane protein.
Sequence:
MLNQFPKLRLTPFTTGIVAIFLFSLVIRFWNLGQFNQLVFDEVYYAKFASDYWLGNDFFPSHPPLSHYLIALAMGLGQVFPVNPEQVNDLTGAVRSTWSYRWLNALTGATIPLLLGAIAYLLTQRRLVTLLTMGLVALDGLFLVESRYALNNIYLVFFGLLGQALVLWHLRQEKLWQLILGGISLACAGSVKWNGFAFLLGVYLLWAIAWVKPFFNQGWTKGERQANSLQLLDRDGENNQGFLSRWLIISPLKFAIWLVLVPVITYSVIWIPHLLMNGEYASLEGFWRIQRETWQYHRRVGNSPDIHPYCSPWYSWLLMARPIAYFYQKSGQFGLINDVHAMANPILLWFSTGAMALLTGTVIWQKIRQFSSQTINAPLRGITLYIEVNYAVNLLPWLGISRCTFFYHYLPAYAFSILALALILETLLDSPRHSHNVIAWAVLTLVAIAFWYWLPVFLGLPLTPRGFALRMLFPSWI
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing; Probable common Sm protein, is found in U1 and U2 snRNPs and may be part of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MSGLYVHCLPISSVKLNANRVVIGTLRGFDQFMNLVIDNTVEVNGNDKTDIGMVVIRGNSVVMIEALEPVAKSQ
The following text describes a protein:
Function:
Involved in the regulation of lipid homeostasis in the endoplasmic reticulum, thereby impacting nuclear pore complex biogenesis and localization, and nucleocytoplasmic mRNA transport.
Subcellular Localization:
Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSLTSVLWNFVAKLAVDHGLNTNPDQVFQTVENVGKSFEKYETSFLKSLFNGNLGLSLPSAINILTLIIVLYFSLVIVNKTTSIALALFKTLAVISFFLLIGCLFAYWFINNGSF
The following text describes a protein:
Function:
Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
Sequence:
MKERVIITGANGQLGKQLFEELDSEEYDIYPFDKKLLDVTNISRIQQVVQEIKPHIIIHCAAYTKVDHAEKEQDLAYRINAIGARNVAVASQLVGAKLVYISTDYVFQGARPDGYDEFHSPAPINIYGASKYAGEQFVKELHNKYFIVRTSWLYGKYGNNFVKTMMRLGKERDEISVVADQVGSPTYVADLNMVINKLIHTSLYGTYHVSNRGSCSWFEFAQKIFSYANMKVNVLPVSTEEFGAAAARPKYSIFQHNMLRLNGFSQMPSWEEGLERFFIETKSH
The following text describes a protein:
Function:
Golgi membrane protein involved in vesicular trafficking and spindle migration.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MPADDYDVRALALPLEDEETGETPVWSRRSTSSFRRTPSHHGQQSMRQRIMTSYDKASRRVMEQYNKLTVLQKVLLLLATILLVVFGILFLIYNERIFGKLVPVAKKWRDIRAGWLILWALIFAVSFPPLVGHGTLMTIAGFVYGFPNGWYIAASATILGSTASFIASRSLLKSFVDRLIKGDKRFAALALTLKHDGLKLLVMIRLCPLPYSLSNGAIATFPTVHWASYGLATAIISPKLMLHIFIGSQLEKIAESGGKMDPKTKAISYLSIGIGAIAGIVTGWFMYKKTRERAAQLEAEERAGIRRASIEDLEREYSDDPEALGAAETLREEEDDISLNTTWDDEYHDEPVVTEDDAIEIGDDPFKDGDGDASEDEERGKK
The following text describes a protein:
Function:
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18 (By similarity). May be involved in spermatogenesis.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei (By similarity). In spermatids, associated with chromatin and nuclear matrix.
Domain:
The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
Sequence:
MLKVTVPSCPSSPCSSVTASTENLVPDYWIDGSNRDPLGDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDARDAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVKKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHTSIQENHKASSDPPSTQDAKDSTDLLGKKMQEEDQEEDQVEAEASADEMRKLQSEEVEKDAGVKEEETSSMVPQDPEDELETDDPEMKRDSEEKLKSVEEEMDPMTEEEAPDAGLGVPQQDAIQPEY
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSEKETIESLKEEIEIHDRNKSNKGYLPKESYNQVTYDYSKEEEQAKLAHLPKKYLKESENDDKHFIDPLANLTPAQRKVYELRKKLETTKSVIYKSVVDEHKRIHQGAQDEIEEKKRLYKEKIKQEEEEMKKQGLDPQKERLKNQIAEEIKPNKKEKKKDSIVKDKSNTYSDEHVYNSYKKRVKEMEKFHNSEHFKKVVSNEDVKESGDSINNNKYEYGKSIEIPRDNINAMKQELLKNQENRRSFKRKSFKEEEDINYINEENRLFNQKVSRAYDKYTVETRQNLERGTAL
The following text describes a protein:
Function:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
Sequence:
MKKFFAKVTKHDKKDDKDKEEKKKEEKKKDKSHHEKEESQKIKEEAKKKAEEEAKKKAEEEEAKKKAEEEAKKKAEEEAKKKAEEEAKKKAEEEAKKKAEEEEAKKKAEEEAKKKAEEEAKKKAEEEAKKKAEEEEAKKKAEEEEAKKKAEEEAKKKAEEEAKKKAEEEAKKKAEEEAKKKAEEEAKKKAEEEKKNQPQGLGLGGGLGQPQGLGLGGGLGQPQGLGLGGGLGLGGGLGQPQGLGLGQPQGLGLGQPQGLGLGGGLGLGGGLGQPQGLGLGGGLGQPSGLPSLGQPSMPVTSEQGSAGISGGELQMKGTGKKTIKKKKMGVAQSAFFAHENEEKANAMLSKIADDAVLVFDCGSSFIKVGVAGEEQPRKVIPTCYCVIEDEEYEGGERKEFGYKAIDENAKLIWPLDPRNDTDWDGLFDIIQNIYQVELNELEPSAHAVVMTDLPNMNEVATDKIKSMMFNDLNVPFLKIVNPALMALYAEGKETGLVVEIGNRMQIVPAVDGFVIDSAITKIKGNVSGLTEYMQRLLRSCGYIYTTSQQMELVRAIKENVCYVALDYDAEMKRKPREIMKEYKVPGNDNTSKFFQERFQCPEALFKPEKVGIDTEGLPQMIFECIKKCPLTSRRPLLNHIILAGGSTLFPGLPERLDQDLKKILEENKMNSRDVKIIVHQNRKYLAWAGAALLAGMSTLQDEEQCTKDYYDNN
The following text describes a protein:
Function:
Required for receptor inhibition of inappropriately expressed a-factor receptor (STE3) in MAT a cells. Inhibits signaling by relocalizing the G protein beta-gamma (STE4-STE18) subunit to intracellular membranes. May also be a mechanism for the down-regulation of the mating pheromone response after the zygotic fusion event, promoting the transition of the new diploid cell to vegetative growth.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MTTLASSIEHKTKHLAAPFENDENPWMKKYCCQCKSCKMSVPVQPWLPRFFVFGILCPVFWLVNLLAWWFLQYWQPHELEFHDLQEDEYPGFYEYEAITKRTVIPIKEEVLQEIRVMQNFSDSNSEEYYESKDGMPSSFLNVNTEQVEDENDTLKKYRYAFLKKVAHDVLESHDLLRKTFRDWNLRSLLGLLIDSILIIFVVLLCKKSR
The following text describes a protein:
Function:
Accessory subunit of the DNA polymerase that plays an essential role in viral DNA replication and acts by increasing the processivity of polymerization. Forms dimers that binds to double-stranded DNA and UL54 specifically to stimulates long chain DNA synthesis efficiently. Plays an important role in maintaining the structure of viral replication compartments by interacting with host nucleolin/NUC. In addition, suppresses innate immune responses through effects on host IRF3 and NF-kappa-B. Mechanistically, interfere with the binding of IRF3 and the p65 NF-kappa-B subunit to the promoters of antiviral genes, thereby inhibiting the expression of these genes.
Subcellular Localization:
Virion. Host nucleus.
Domain:
The C-terminal region is required for viral DNA synthesis.
Sequence:
MDRKTRLSEPPTLALRLKPYKTAIQQLRSVIRALKENTTVTFLPTPSLILQTVRSHCVSKITFNSSCLYITDKSFQPKTINNSTPLLGNFMYLTSSKDLTKFYVQDISDLSAKISMCAPDFNMEFSSACVHGQDIVRESENSAVHVDLDFGVVADLLKWIGPHTRVKRNVKKAPCPTGTVQILVHAGPPAIKFILTNGSELEFTANNRVSFHGVKNMRINVQLKNFYQTLLNCAVTKLPCTLRIVTEHDTLLYVASRNGLFAVENFLTEEPFQRGDPFDKNYVGNSGKSRGGGGGGGSLSSLANAGGLHDDGPGLDNDLMNEPMGLGGLGGGGGGGGKKHDRGGGGGSGTRKMSSGGGGGDHDHGLSSKEKYEQHKITSYLTSKGGSGGGGGGGGGGLDRNSGNYFNDAKEESDSEDSVTFEFVPNTKKQKCG
The following text describes a protein:
Function:
Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a signaling compound secreted into the host's cytosol where it triggers the cytosolic surveillance pathway (CSP), a host pathway of innate immunity characterized by expression of beta interferon (IFN-beta) and coregulated genes. Expression of truncated proteins (missing first 80 or 100 residues) in E.coli leads to c-di-AMP synthesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDFSNMSILHYLANIVDILVVWFVIYKVIMLIRGTKAVQLLKGIFIIIAVKLLSGFFGLQTVEWITDQMLTWGFLAIIIIFQPELRRALETLGRGNIFTRYGSRIEREQHHLIESIEKSTQYMAKRRIGALISVARDTGMDDYIETGIPLNAKISSQLLINIFIPNTPLHDGAVIIKGNEIASAASYLPLSDSPFLSKELGTRHRAALGISEVTDSITIVVSEETGGISLTKGGELFRDVSEEELHKILLKELVTVTAKKPSIFSKWKGGKSE
The following text describes a protein:
Function:
Endoglucosidase that acts as a host immune evasion factor by mediating hydrolysis of the N-linked glycan from the Fc region of host immunoglobulin-gamma (IgG) during infection. Specifically catalyzes the hydrolysis of the beta-1,4 linkage between the first two N-acetylglucosamine residues of the complex-type N-linked glycan located on 'Asn-297' of the Fc region of IgG antibodies (IGHG1, IGHG2, IGHG3 or IGHG4), thereby preventing interaction between IgGs and Fc receptors and ability to activate the complement pathway. Shows a specificity for biantennary complex type N-glycans; does neither cleave larger complex type glycans nor oligomannose and nor hybrid-type glycans. Specifically acts on IgGs; does not act on immunoglobulin alpha, beta, delta or mu.
Subcellular Localization:
Secreted. Host extracellular space.
Sequence:
MDKHLLVKRTLGCVCAATLMGAALATHHDSLNTVKAEEKTVQVQKGLPSIDSLHYLSENSKKEFKEELSKAGQESQKVKEILAKAQQADKQAQELAKMKIPEKIPMKPLHGSLYGGYFRTWHDKTSDPTEKDKVNSMGELPKEVDLAFIFHDWTKDYSLFWKELATKHVPKLNKQGTRVIRTIPWRFLAGGDNSGIAEDTSKYPNTPEGNKALAKAIVDEYVYKYNLDGLDVDVEHDSIPKVDKKEDTAGVERSIQVFEEIGKLIGPKGVDKSRLFIMDSTYMADKNPLIERGAPYINLLLVQVYGSQGEKGGWEPVSNRPEKTMEERWQGYSKYIRPEQYMIGFSFYEENAQEGNLWYDINSRKDEDKANGINTDITGTRAERYARWQPKTGGVKGGIFSYAIDRDGVAHQPKKYAKQKEFKDATDNIFHSDYSVSKALKTVMLKDKSYDLIDEKDFPDKALREAVMAQVGTRKGDLERFNGTLRLDNPAIQSLEGLNKFKKLAQLDLIGLSRITKLDRSVLPANMKPGKDTLETVLETYKKDNKEEPATIPPVSLKVSGLTGLKELDLSGFDRETLAGLDAATLTSLEKVDISGNKLDLAPGTENRQIFDTMLSTISNHVGSNEQTVKFDKQKPTGHYPDTYGKTSLRLPVANEKVDLQSQLLFGTVTNQGTLINSEADYKAYQNHKIAGRSFVDSNYHYNNFKVSYENYTVKVTDSTLGTTTDKTLATDKEETYKVDFFSPADKTKAVHTAKVIVGDEKTMMVNLAEGATVIGGSADPVNARKVFDGQLGSETDNISLGWDSKQSIIFKLKEDGLIKHWRFFNDSARNPETTNKPIQEASLQIFNIKDYNLDNLLENPNKFDDEKYWITVDTYSAQGERATAFSNTLNNITSKYWRVVFDTKGDRYSSPVVPELQILGYPLPNADTIMKTVTTAKELSQQKDKFSQKMLDELKIKEMALETSLNSKIFDVTAINANAGVLKDCIEKRQLLKK
The following text describes a protein:
Function:
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MKSISGVYQVDVNGERFNTKPRGLFRKKKFSPVVGDIVEFEVQNINEGYIHQVFERENELKRPPVSNIDTLVIVMSAVEPNFSTQLLDRFLVIAHSYQLNARILVTKKDKTPIEKQFEINELLKIYENIGYETEFIGNDDDRKKIVEAWPAGLIVLSGQSGVGKSTFLNHYRPELNLETNDISKSLNRGKHTTRHVELFERQNGYIADTPGFSALDFDHIDKDEIKDYFLELNRYGETCKFRNCNHIKEPNCNVKHQLEIGNIAQFRYDHYLQLFNEISNRKVRY
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus.
Sequence:
MKGFVVISRFILTLFILITPGLAGVVNYAENSEWNVPKYGNVLDSNCQGQKPVTFFGSVTEHVSNSWWIKLYDYMMTFISGEKLCMQNVAYEFEDISLCMDVVGSKCIPTLQSTDIEKVVNSTSAYLENSESDLTLGCFQIQRFQEESTLYIRALKSSEPVSCDTVRCIHFNHIPYV
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MLLIATALLVTANVAMGEPGTAANAVKDECTERKYLANLLTHFSGKLNNLFGTVQALSKQQKQLRLAAEQHAMTKVGMAYTLLEAISSQRLDKAISKQQAATTTVTQLSEQVGSRIGLLLLSRVKAGAATVKYTTPAKEDTTTPAKNGDFSTRCGVHPIVTPPANTKCNTEPADSELNKAGEQIASETKLKFLSATTIKAIPLFASLQAKSTPSTTAPLTANDGCGNNAGGGTNGIAIQGLATVDKTIAHDTIPIETENACKTPKPNSNDDPTETANLVYKVCLAQKADLAMQPALSSETLDELAADTTAQEAALILTGQSTKEQDANKRKAAVANVLGKGKDTVAKKFLEKLTETNVALKLQDDAQPVSIETASGNNFHKALALFTAQAHQRSVPPEKPTNAEGSPKQADSGSKTENKKDGSNTAKPVCCTFQNQTACNNGQNRKWENNTCKDSSFLVKNKFSMMVSAFVSLLEFHLSKDYCSN
The following text describes a protein:
Function:
Has a role in the development of the spore envelope.
Subcellular Localization:
Endoplasmic reticulum. Spore wall. Note=Endoplasmic reticulum during meiosis. Located at the spore rim at the end of meiosis.
Sequence:
MRLVLLFSCVLAVSSYAEIILAHSDENLLSRTKNNLSKWNENRLYDYGSKSTMSLPVSSLFPALQTLWIGVVADCSYVTHFTSRMEAKKHIFQEFEGVSTLYEDSFNINVQIHSLILPSAHDCSANVVDRPEISMSPRISIEEKLEIFSKWKYESPGNNVFEAISPHERESFPSEPQVSVLFTSSVKRSPHGVSWFATICSETHIENEWHVGPLSVVSAYPNDRLVVAHEIGHILGLIHDCNKKSCGDHSEACCPLSSSLCDAQELYIMNPSNSYTYANLRFSDCSILQLHSLVEKKYVSLSCLSKPSEKSVLRLGTCGNGIVEDGEECDCGEDCENNPCCDGKTCKLTKGSLCDDQQDACCYQCHFKNAGTLCRQSTNPCDKPEFCTGISSKCPVDENWDDGRICQDSLGMGSCASGVCTSASRQCKKLTNFSSLSCHSDSCKVSCQNEDGTCFISAKDYIDGTRCRGGLCYNGVCVPIEGSSASWSKQPSLFCASGTMLISLAVIAWFFW
The following text describes a protein:
Function:
Multidrug efflux pump.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSPADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLSIAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKTRVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKNAPFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIASHQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAACILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLAAAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQHI
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MAANPAGALDWDLVKVQLDSIDDAWKQPRFDSLPYVVEVITSPNIEASVERLRETRDAIEEIVDGVVRHYHNGFNKAIHNYSQILRVFSESAGSLDSLKEDLAEARKLLGARHKQLQQQWSRSVTLRHVISLLDEIDKVSQVPARIERLAAEKRYYAAVQLHLQSISMLDREGIQTVGALQDVRAELTKLRGVLFSKVVEDLHLHLYNRGDYSMNLATTHEQDDDITSIVPAAVPAVGNLQPVSRRTRTLTRNPSSISSVERRRTSSDSQSVENEFATACDNADGSTDDIRVSSNASDDSAAKEADEKARSHPPWLSESIPNDFTEALLKSDAPSGVKYLQTMVECLSLLRKIPEGGSIISQRLRPTLHELITSEIKARAKAIEACRPRVDEAQKLLESSIMGKYSTSGQKKVKKEISSTADAGPMSKLQTAAQELLQSVLTLVLQILENHVVVGQLMEAKEHSFLTSNGHASWSNDVEVSQTEGNHSLGGVLTVIQSEVQQLICDILRATPDATSAESAAQTARLASKTPITNFKNPFGVKNKEESNGGSEEGLSFAFRFTDTILTPPGQTELKSSGSLRRGHNRKRLPASQDGYGTGAVLSERGIYLTSAIYRPILQFIDKMASLLPPKYSSLTNDGLQNFIEKFVKNQFLPIVHVDYRTRVADALASPSAFRLKAHPGALYEDSVEKGRPVLQGPIAANHLVTEVLGWAQAMPKYASEILELVQTLLDRTLERCRAVYTEAVLGSLSSTVIGRPDICNLMKQEPANQLLEATYLNQLGFKDGPSVDIEGALEVEMELNNLLLSLRPIRKEQLISDHHKLVLLAGLSDSLDFVSESVQQLGQHNNAAPSPAPSMSRRNLTQSPQIRHRRTNSALTTGLGILAEKYRMLSCECLQTLRVEMQLATIHHLQSMAGRHYVRDQDAEEPEDFIVALTSQIQRVAEEMAAYMPPSKRSYIFGGICSVSAAAFIKAVTNMDAINMLGVRQVNRNCIALQQALASLVASSGEFLEERLDRVRTYYDLLTIPFEALIALVPENDAIFSLTEYSALLKVNVPGREIPANAVQRVAKILAPTR