lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export.
Miscellaneous:
MISCELLANEOUS: Present with 5260 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm, but is largely cytoplasmic owing to efficient nuclear export. Nuclear exclusion is mediated by the exportin CRM1.
Sequence:
MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE
The following text describes a protein:
Function:
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Sequence:
MKPSERRKARRLAVQAIYSWQLSGNNIADVEHEFLTEQSLDGVDVAYFRELFAGVATKKTQLDELIIPHLDRPIDEVSPVEKAIVRLAAYELTFRKDVPFKVAINEAIELAKAFGADESHKFVNGLLDKLVARK
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MADSPFPRSSRSGLLRTTLNSSMPPQNLSHSLLILEKSNAEQNELSLMEDTGDDLDRGKSRMDVLFPQFFDVLQAQGNGQEAFEVIQSLTQVCRGVVEQLELEIDHGMGGEQGARQRESMLTWLRXXXXTWRLLHALFYDRILLQTDRQADDEMQDGPTLGGSEKEVIQQLYALNATLREYQLVVDWLEACYDRGEQQNPLHAHDRMMAWENTLFQLENLQGAAFGKGHKIVTRLDPDAPVREKRPLHALDEEDNLRLSRAIFELIRAGRVDDGLKLCKHFGQTWRAAILEGWRLHEDPNFEQNVSVLHEKLPIEGNPRRDIWKRCAWMLADSKNYDEYSRATAGVFSGHLGSLKTLLHSNWHDLLWAHLKVQIDIRVESEIRGCCLKNYQPMPDDYWNGRMTMEQIFEELNVAKDASVRDFAQSQLGIIQRHLILDTCGELIQHMVRWVEKDTSQQSPHQLRFMAHIVLFLRQIGRVEQERQAEKIVAAYVEALIARGEPQLIAYYTASLSNPLQVQLYSRFLEQVEQKRPRELAVDAALQAGLDVEQITRVTVQNIRLAHQPLGEFGEPQSGEISAIDQRKISALEWLIHLPEQRGELLWQANAMIRTYLASSKVECMRQTFRMVPADIVQQLVSLYGSVDNIPPREECCLKEYLCYKAYLSGVDSFVEWNRLQQNRPKKPQTSHAASSQDNFTERMASERKEQAHRSEVVRWEHKVKEQAKQTIELLYNVLMFPDKGWLVDPFIAKLPENAVQLNWDHRLLQMEKLRSICIPEIALFLNEVMFKSGDFAGCVRLADEISSDNRQLYKVYTKHKLAELLAKIADASLELLNSKLDPWGYPITT
The following text describes a protein:
Function:
DIG1 and DIG2 are negative regulators of the filamentation and pheromone induced mating program. DIG1 and DIG2 inhibit the transcriptional activity of STE12 by direct protein-protein interaction. DIG1 colocalizes to promoters with STE12 and redistributes with it during induction of filamentation (by butanol) or mating (by pheromone) to program specific genes, but binding of DIG1 to STE12 is reduced by pheromone treatment.
Miscellaneous:
MISCELLANEOUS: Present with 5000 molecules/cell in log phase SD medium (5480 according to TAP-tag study).
Subcellular Localization:
Nucleus.
Sequence:
MAVSARLRTTAEDTSIAKSTQDPIGDTEISVANAKGSSDSNIKNSPGGNSVGQESELEHVPEEDDSGDKEADHEDSETATAKKRKAQPLKNPKKSLKRGRVPAPLNLSDSNTNTHGGNIKDGNLASSNSAHFPPVANQNVKSAPAQVTQHSKFQPRVQYLGKASSRQSIQVNNSSNSYGKPHMPSAGIMSAMNPYMPMNRYIMSPYYNPYGIPPPHMLNKPIMTPYVSYPYPMGPRTSIPYAMQGGNARPYEENEYSASNYRNKRVNDSYDSPLSGTASTGKTRRSEEGSRNSSVGSSANAGPTQQRADLRPADMIPAEEYHFERDALLSANTKARSASTSTSTSTSTNRDRSSWHEAEPNKDEEEGTDLAIEDGAVPTPTFTTFQRTSQPQQQSPSLLQGEIRLSSHIFAFEFPLSSSNVDKKMFMSICNKVWNESKELTKKSSSHHRTGK
The following text describes a protein:
Function:
Mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLVAMSMTPIAILFSTPLKRFLREKVLLGNAPSWELLAILSIYFVQGVLGLSRLAVSFFLKDELGLSPAAMGALIGLGAAPWILKPVLGLMSDTVPLFGYRRRSYLWLSGLMGSAGWLLFAAWVSSGTQAGLVLLFTSLSVAIGDVIVDSLVVERAQRESLAQVGSLQSLTWGAAAVGGIITAYASGALLEWFSTRTVFAITAIFPLLTVGAAFLISEVSTAEEEEKPQPKAQIKLVWQAVRQKTILLPTLFIFFWQATPSAESAFFYFTTNELGFEPKFLGRVRLVTSVAGLIGVGLYQRFLKTLPFRVIMGWSTVISSLLGLTTLILITHANRAMGIDDHWFSLGDSIILTVTGQIAFMPVLVLAARLCPPGIEATLFALLMSVMNLAGVLSFEVGSLLTHWLGVTETQFDNLALLVIITNLSTLLPLPFLGLLPAGDPQVKDKTEKEDNPDDPGDRLVLPPAEVFEHHTVGSLSDQNFLPEFFPEKSSSRP
The following text describes a protein:
Function:
Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.
Subcellular Localization:
Membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MALQTPKQRAANLRFAKANEKKVGKKKKTGSKTEYPISKTWILVLLFLLVGGGVLELVSLLF
The following text describes a protein:
Function:
Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MFTPTDISGEPSAVGTQWTPYLSHPVDFGAQHFLEAMLNVISQPNINSSVIMRADIISDSLNMMPNIMGTDKANEGFIFDTHEGPVDDDKKDTDKDKNTPVPPNLQDYEPRQVEVTPCPVKRVIVRRIIPRNPQNDFSVNQTCIVHSDKPLWDSDGKETSEGAKIAISYISHHDHPKSCPYYLPCVKAVLLYFDGSAISVYYEKYTDYELSAEQEERCGRIALHLLHTVFRHSSGQKAGYKKRVHHDMIIDRIKFQDRYIYLKQKYAHSLVSSWVESTDPRKHVFEDLAIAAFLIELWGQMYKNKDDIYFYDLGCGNGLLVNILIKEGYVGEGVDARARKSWQTYEPEVTQKLLEKIVVPTVLLDQMVGQAQYLPPHAAEKRLAEANGLATDPRVFQTAGLPENAFLIGNHSDELTCWIPLMDRPFMVIPCCSHALSGEKKRFPPTSSDPEEKSTYRSLVGHVEQLSSKIGWQVEKEYLRIPSTRNAAVIGRTRVEPQMNIFEILYSEGGGEGWVERARDLCAKSPRNH
The following text describes a protein:
Function:
Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.
Sequence:
MIEDNKENKDHAPERGRTAIIFSLKNEVGGLVKALKLFQEKHVNLVHIESRKSKRRNSEFEIFVDCDSNREQLNEIFQLLKSHVSIVSMNPTEHFNVQEDGDMENIPWYPKKISDLDKCANRVLMYGSDLDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPEIEFTEEEIKTWGTVYRELNKLYPTHACREYLKNLPLLTKYCGYREDNIPQLEDVSRFLKERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDEAVQKLATCYFFTVEFGLCKQEGQLRVYGAGLLSSISELKHSLSGSAKVKPFDPKVTCKQECLITTFQEVYFVSESFEEAKEKMREFAKTIKRPFGVKYNPYTQSVQILKDTKSIASVVNELRHELDIVSDALSKMGKQLEV
The following text describes a protein:
Function:
DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA. Provides the majority of the AP-endonuclease (APE) activity. Repairs phleomycin D1-induced DNA damage. Plays a role in oxidative damage repair.
Subcellular Localization:
Nucleus.
Sequence:
MRILSWNVNGIQNPFNYFPWNKKNSYKEIFQELQADVICVQELKMQKDSFPQQYAVVEGFDSYFTFPKIRKGYSGVGFYVKKDVAIPVKAEEGITGILPVRGQKYSYSEAPEHEKIGFFPKDIDRKTANWIDSEGRCILLDFQMFILIGVYCPVNSGENRLEYRRAFYKALRERIERLIKEGNRKIILVGDVNILCNPIDTADQKDIIRESLIPSIMESRQWIRDLLLPSRLGLLLDIGRIQHPTRKGMFTCWNTRLNTRPTNYGTRIDYTLATPDLLPWVQDADIMAEVMGSDHCPVYLDLKEEYEGKKLSNFLSHSKEPPLLSTAHHSAYRPSKNIHSMFQHFNSMKKNKNNSPTQSENVSASASSGSSPTVSRANSVIDVDAYPPEKRRRKEQSKLLSFFAKQKEEKEETNKTEDVSIEVLDNNNESDIGLTVKKKVENGNAWKQIFSERAPPLCEGHKEPCKYLTVRKPGINYGRKFWICARPVGELIKNSNAVSEEDTQPFQCRFFIWDSDWRANSKD
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MASQRRTMQKLAKGAGVVPVNLLLLVSVCLIGALSGAGMVSASAIPAASFPSNGNGIANSASADVGGHHRRPSCVAVHPLLKQRGVDPIDMPIDPIPDLNLRHCEVPPGGGTCCTQMTEHKLALHTKTMVERNIKDNISKLSSVLGTRAQRFNEFFEELLVQSKHGFHAMFKRTYGTIYEQNSYVFADLFAELERYYAHGKVDLSETMDHFFNILFQKMFTVLNAQYTFDNKYLGCVSEHMKELKPFGDVPDMLSLQIKRSFIATRKYAQALASAAEAARNMINVRLSAECTAALTRMSTCNVCAGQTKKPCESYCVNVMKGCFPSYEEIGTEWDTFVSKMERIAERLLGPFNIVMVVQPIDVKISEAIMNFQENGKDISDRIFQGCGQPALGRMRRSASKQVADSFATNGFESQPRLITTMGQQQLPLVEGIGRRAIALPAPDSTESADSQFTFEGEEQDEDTAADASDKRISKRAAGTNADGGDSTSRELKYEPLQFSDGDVQFTNSNGPPVSGSTGNSAGSGDGSAAGARANRRKQKGGRKQASEQDEQDIQEPMIDRMVRDIRQKVSNSRRFWTQLPYMLCNNEEVAEPPANDASCWNGTTVDRYQPNIILGETDTNPEFPNRVFQGRQSTIVQQQLFILRTAISHLSHAYVGHAVEWTDQEDGYYGSGSGQGSGIDYEETAGSGMGLWEIDVRNERRPGADDVFVPPKISFDSPRGPSGGISEIGHGPTTNDLDYTASAGVPSVAGSGDAAGSGGAGGTSTAGSSHTTPVLSIERALLQFFLPIVMAWFGGLFAELL
The following text describes a protein:
Function:
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays a role in various cellular and molecular mechanism through its association with both integrin and non-integrin proteins. These interactions facilitate critical cellular functions, including cell-to-cell communication, wound healing, platelet aggregation, trafficking, cell motility, and angiogenesis. Via interaction with JAM-A/F11R and integrin ITGA3:ITGB1, promotes the recruitment of signaling molecules such as RAC1, CDC42 and RhoGTPases to facilitate the polarization of epithelial cells and the reorganization of the actin cytoskeleton, which are critical steps in cell migration process. Regulates the glycosylation pattern of ITGA3:ITGB1 thereby modulating its activity. Plays an essential role in the maintenance of central laminin-binding integrin ITGA6:ITGB4-containing adhesion complexes. Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. Contributes to T-cell activation by modulating integrin signaling leading to activation of downstream targets PTK2 and MAPK1/MAPK3.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Relocalizes to the immune synapse in T-cells upon activation.
Sequence:
MGEFNEKKATCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASSTYLATAYILVVAGVVVMVTGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYVYYQQLNTELKENLKDTMIKRYHQSGHEGVTNAVDKLQQEFHCCGSNNSRDWRDSEWIRSGEADSRVVPDSCCKTVVTGCGKREHASNIYKVEGGCITKLESFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRSLKLEHY
The following text describes a protein:
Function:
Stimulates pro-inflammatory cytokine expression via TLR2 signaling pathway. Activation of TLR2 results in the phosphorylation and activation of NF-kappa-B. Also induces TLR2 expression. May influence the innate immune responses to facilitate the survival of M.tuberculosis in the granulomatous microenvironment.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MTAAVDGKGPAAMNTHFPDAETVRTVLTLAVRAPSIHNTQPWRWRVCPTSLELFSRPDMQLRSTDPDGRELILSCGVALHHCVVALASLGWQAKVNRFPDPKDRCHLATIGVQPLVPDQADVALAAAIPRRRTDRRAYSCWPVPGGDIALMAARAARGGVMLRQVSALDRMKAIVAQAVLDHVTDEEYLRELTIWSGRYGSVAGVPARNEPPSDPSAPIPGRLFAGPGLSQPSDVLPADDGAAILALGTETDDRLARLRAGEAASIVLLTATAMGLACCPITEPLEIAKTRDAVRAEVFGAGGYPQMLLRVGWAPINADPLPPTPRRELSQVVEWPEELLRQRC
The following text describes a protein:
Function:
Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.
Subcellular Localization:
Nucleus.
Sequence:
MEASVGERFYHMGGPDLRGLGKRSLEWDLTDWKWDGDLFIATPLHQNAPNYQSRQFFPVETGNLASSNSSSSCSEEVNHGMEQQRRELEKRRRVIVVEEDDSGPLSLKLGGQGEPAAASAXPGTKLVAPAGSRAVCQVDDCGTDLSKAKDYHRRHKVCEMHSKASRALVGNVMQRFCQQCSRFHALQEFDEGKRSCRRRLAGHNKRRRKTQSESVANNNSVNEGQASGYSLMSLLKILSNMHSNGTNPTEDQNLLSHLLRSLASQGTTNGDKSLSGLLQESSNLLNNRSILRNPEVASLISNGSQAPPRAKEHQFTNSATEMPQKRLDVHDVRLEDARTASSQSPGILFPIQSNSQAYTPGRESTTGRSKLMDFDLNDAYVDSDDCGEDLVRSPVPECPSWLQQDSHQSSPPQTSGNSDSASAQSPSSSSGDNQNRTDRIVFKLFGKDPSDFPFVVRAQILDWLSHSPTEIESYIRPGCIVLTIYLRLPESAWEELSYNLSSSLSRLLDVPGGDSFWTRGWIYIRVQNQIAFVCDGQVLLDMSLPYVSNDDSTLLSVRPIAVPVSGRVQFLVKGYNLTKPSTRLLCALDGSYLVPEANNEVEEHGDVVGKDDKIQSLNFTYSVSAVAGRGFIEVEDHGVNNSFFPFIIAEEDVCSEIRMLESDLELSSSDYVNGQTSNMEARNQAMDFIHELGWLLHRNNLKARLDHFGPNAVLYPLKRFKWLVDFSVDHDWCAVVKKLLNILLDGTVGAGDNSFLKFALSELGLLHRAVRRNSRPLVELLLTYTPESVADELCSEYQSLVGIDGEFLFRPDCVGPAGLTPLHVAACIDGYEDVLDALTDDPGKVAIEAWKNTRDGAGFTPEDYARLRGHYSYIHLVQRKISKKATSGHIVVDIPSVPAVVESNNQKDEVYTTTSLEITMTERTPIARPCGLCDRKLAYGSRGRSLLYRPAMFSMVAMAAVCVCVALLFRGSPEVLYIFRPFRWEMVDFGTS
The following text describes a protein:
Function:
Catalyzes the final step of sucrose synthesis.
Sequence:
MERLTSPPRLMIVSDLDETMVDHHKDPENLALLRFNSLWEDAYRHDSLLVFSTGRAQTMYKKLRKEKPLLTPDVIITSVGTEIAYGNSMVPDDNWVEILNKKWDRGIVQEETSKFPELTLQGETEQRPHKLSFNIDKSKVKAVTKELSPRLEKRGVDVKFIFSGGNAFDVLAKGGGKGQALAYLLKKLKTEGKLPINTLACGDSGNDTELFTIPNVYGVMVSNAQEELLEWYAENAKDNANIIHASERCAGGITQAIGHFKLGPNLSPRDVSDFLECKADNVNPGHEVVKFFLFYERWRRGEVENCTTYTSSLKASCHPSGVFVHPSGAEKSLRDTIDELGKYYGDKKGKKFRVWTDQVLATDTTPGTWIVKLDKWEQTGDERKCCTTTVKFTSKEGEGFVWEHVQQIWSEETEIKDDSNWII
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MADAALRDRLNTLVTSMFATDMLDENFHQLKSMEEDGTAAPGYVADIINLFISNTKRILNDIAALLNQPVVDFDMVDVLVRQLKGCSYRPRKQEDFDSAKQTAHKEKTLVPLTTGTRFFDR
The following text describes a protein:
Function:
Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation. The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II. The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2. Involved in fetal development, T-cell function and adrenal gland growth homeostasis. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm. Note=Associates to RNA polymerase II (Pol II) on chromatin.
Sequence:
MAAARPALTDSLSFCLAQLTAAAGEGPGGGKDPATNETALGRVLLALRTRHIKAAEGIERFRARGGLRPLVALLRRTAAAGPAPSQAASGSAPPSVASAGSSPGPAPAAESPLTLSAPMRLRKTLDLALSILANCCTEGACRSEVRRIGGILPLVTILQCVRIDSIQNRTARALGNLAMEPESCGDIHSAGAVPFLVESLTACQDSQCLQSIVRALRNLADSPQHRLALAQQGAVRPLAELLATAPDPALTSALVRALLELSRGCSRACAEQLSLGGGLGPLVSLASHPKRAIREAAILILANLCAQGLVRPALGNAGGVEVLLGELRRRRGPSGSSSASQQPLVRAVCLLCREAINRARLRDAGGLELLMGLLQDPGASAWHPRVVAALVGFLYDTGALGKLQALGLVPLLARQLCGEAGEEEEEGVEAASWDFPEERTSGQPEGGSFRSLRLWLISEGYAAGPGDISPDWSPERCPMPEPSESVSPTPGQTSMSTPRTLRKLGRVPAATTEEPWGQEGPALLLLSRFSQAPDPSGALVTGPALCGLLAYVTGAPGPPNPRALRILARLTCNPACLEAFVRSYGAALLRAWLVLGVSPDDWPVPHARPVHRSQHRELGEMLLQNLTVQAESPFGVGALTHLLLSGSPEDRVACALTVPFICRKPTLWRRLLLDQGGLRLLLTALTQPAPHPLFLFFAADSLSCLQGLVSPSASPVPLPDLPLELDSPSPCLYKPLLGPAPAPAPDLHFVLDSGLQLPAQRAASAAASPFFRALLSGSFAEAQMNLVPLRGLSPSAAWPVLHHLHGCRGCGAALGPIPPPGQPLLGSKAEEALEAAGRFLLPALEEELEEAVGRIHLSPQGGPESVGEVFRLGRPRLAAHCARWTLEPGQCPRKRALALTGLVEAAGEEAGPLTEALLAVVMGVES
The following text describes a protein:
Function:
Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Note=Located at the septum.
Domain:
Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity).
Sequence:
MSMSAIERVIPLVGHLPPSIREGLARRMRELAGLGLIALSGLASAALMTWSVQDASLSHATSRPIRNILGYAGAIGADLAMQILGLGAIMLVLTVAVWGWRMMTHRPFDREALRLGSWILCTVIAAGFVSCWPHGGAWPLPTGLGGVVGDALVRAPAVIFGPPGMIYRTVLGVILFAAMAATFLIACGLGAREHDDELAEIEDDDKPLDEDEESDRGSVSLGWLFHALMSTKARLIWLCGAAYRSLVSSGPKTRAVGFSRQEPNLGGGRAAPPISPRSEDEDYEEEHEEEEDEEEEEEPAARAPRKKAAPKAAAKKSSDKFELPSVSVLAAPKAGDRQPLSKAELEANSRALEGVLQDFGVRGEIVKANPGPVVTLYELEPAPGIKSSRVIGLADDIARSMSALSARVAVVPGRNAIGIELPNAHREKVYLRELLVAKETVDTVAKLPLCLGKTIGGDPVIIDLARTPHMLIAGTTGSGKSVAINTMILSLVYRLRPDQCRLIMVDPKMLELSVYDGIPHLLTPVVTDPKKAVVALKWAVREMEERYKNMAKLGVRNIDGYNTRLLELKAKGEEPTRTVHTGFDKETGKAIYEEEKLSLDPLPYIVIIVDEMADLMMVAGKDIEGAVQRLAQMARAAGLHVILATQRPSVDVITGTIKANFPTRIAFQVTSKIDSRTILGEMGAEQLLGQGDMLYMAGGGRISRVHGPFASDDEVEKVVRHLKTQGQPEYLEAVTAEEPTEDEDGGAVFDASGMGADGGGDLFQQAVAIVKRDRKASTSYIQRRLQIGYNRAASLMERMELEGIVGPANHAGKREILVEEEDSHM
The following text describes a protein:
Function:
Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase.
Domain:
Contains F-X-F-G repeats.
Sequence:
MSPAAAAADGGERRRPPLGVREGRGRTRGCGGPAGAAALGLALLGLALYLVPAAAALAWLAVGASAAWWGLSREPRGPRGLSSFVRESRRHPRPALTASPLPAKSPVNGSLCEPRSPLGGPDPAELLLMGSYLGKPGPPEPALPQDPRDRPGRRPPSRSPPSSSTAQRVHHVYPALPTPLLRPSRRPPHRDCGPLSSRFVITPRRRYPIQQAQYSLLGALPTVCWNGGHKKAVLSARNSRMVCSPVTVRIAPPDSKLFRSPMPEQILSTTLSSPSSNAPDPCAKETVLNALKEKKKRTVAEEDQLHLDGQENKRRRHDSSGSGHSAFEPLVANGVPAAFVPKPGSLKRSLASQSSDDHLNKRSRTSSVSSLTSTCTGGIPSSSRNAITSSYSSTRGVSQLWKRSGPTSSPFSSPASSRSQTPERPAKKTREEEPCHQSSSSAPLVTDKESPGEKVTDPATGKQQSLWTSPPTPGSSGQRKRKIQLLPSRRGDQLTLPPPPELGYSITAEDLDMERRASLQWFNKVLEDKTDDASTPATDTSPATSPPFTLTLPTVGPAASPASLPAPSSNPLLESLKKMQESPAPSSSEPPEAATVAAPSPPKTPSLLAPLVSPLTGPLASTSSDSKPTTTFLGLASASSATPLTDTKAPGVSQAQLCVSTPAATAPSPTPASTLFGMLSPPASSSSLATPGPACASPMFKPIFPATPKSESDNPLPTSSSAATTTPASTALPTTATATAHTFKPIFESVEPFAAMPLSPPFSLKQTTAPATTAATSAPLLTGLGTATSTVATGTTASASKPVFGFGVTTAASTASTIASTSQSILFGGAPPVTASSSAPALASIFQFGKPLAPAASVAGTSFSQSLASSAQTAASNSSGGFSGFGGTLTTSTSAPATTSQPTLTFSNTVTPTFNIPFSASAKPALPTYPGANSQPTFGATDGATKPALAPSFGSSFTFGNSVASAPSAAPAPAAFGGAAQPAFGGLKASASTFGTPASTQPAFGSTTSVFSFGSATTSGFGAAAATTQTTHSGSSSSLFGSSTPSPFTFGGSAAPAGGGGFGLSATPGTGSTSGTFSFGSGQSGTTGTTTSFGGSLSQNTLGAPSQSSPFAFSVGSTPESKPVFGGTSTPTFGQSAPAPGVGTTGSSLSFGAPSTPAQGFVGVGPFGSGAPSFSIGAGSKTPGARQRLQARRQHTRKK
The following text describes a protein:
Function:
Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38.
Sequence:
MATTTPPETKSAAWWNYFFLYDGSKVKGEGDPTRAGICYFYPPQTLLDQQELLCGQLAGVVRCLWDLSGTPPMLIRMRNLKFAIRADGDYLWALGCGVEISDASCRQFLDQLIGFFHFYMGPVSLAYKSHPQEELSLQWDTSITQVLRSTSESHRIFNALWNLDRTKVEPLLLLKAALILQTCQRSPHVLAGCILYKGLIVNSQLLPSLTAKVLLHQTVPADQRLPGAGAAPQETGAALPPDVQITSVFLSEEEVASLHEFPVEHETRLQGSSVQYPPWDQSSPTQAEDAWASAAIPEPTPHDGACPSGSGADERLPRLEQECAGPTGLCTTACGQGSGLSSRLQKELCLSREELDSSEMHVSEAQEAFPPLPALGDLETLHSSHSAPTLPEDTAICSCLHPCPLERLPESGRLGQLADLPLTNGQTQVPGTDPLPSSMPVALPPQHPVGVEPSVEPYGNGAQESHSALPRSSRSPDSPGPSPSADRTGFKPSPSGRHAGLVPMNLYTHSVNGLVLSLLAEETLLSDTAAIEEVYHSSLASLNGLEVHLKETLPRDEASLTSSTYNFLHYDRIQSVLSANLPLVTAPQDRRFLQAVNLMHSDFALLPMLYEMTIRNASTAVYACSSPAQETYFQQLAPTARSSGFPNPQDCAFSLAGKAKQKLLKHGVNLL
The following text describes a protein:
Function:
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Subcellular Localization:
Cytoplasm. Secreted.
Sequence:
MRDGGRMSEPTSTDREKKRPPLNGRRALPSNNSNAEENDVPEMDAFGLIPRGFNPKDYLRVVDIHMFKEPNEINKQQHHTDKYYNPKLIVRRGQPFQIQIDFSRPYDPEKDQIWLEYLIGRYPQPNKGTYIPILIGDVLKPGEWGAKITHRENNSIRLSIMSSATCIIGKFRLYIAIWTPYGIIRTHRNSATDTYILFNPWCQLDAVYLDDEKEREEYVLNDVGIVFHGDVNEVKLRSWSYGQFEENILDACLFLMDKAELELSGRGNPIKICRVASAMINSKDDNGVLAGSWDNLYDYGVPPSAWTGSVDILLEYYSSKQPVRYGQCWVFAGVFNTFLRCLGIPARLITNYSSAHDNNANLQLDFFLDDEGQVDNRLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDGTPQETSDGMYRCGPASVQAIKHGHVCFQFDAPFVYAEVNSDIIYSRMGKNGSQVIEKIDTTHIGKLIVTKGVGNDDMVDITENYKFQEGSAEERLALETAVMYGVKKQTTQPTTYQPQKDIEMDLQVQKAVLGSDFKVTIILRNKSRNSYTATTYLSGNIVFYTGVTKSEFKKHSFSAKLEPLLSNTFDVMITSAEYLNDLLDQASFHFFVTARINETGKVLAMQKAVVLEIPTLKIKTKGQMVVDREMSVVVEFTNPLKQTLENATLRLEGPGVLRTMKKEFRQIPAMSTLIWDVKCIPKRPGLRKLIASLNCDALRHVYGELNIQVQKP
The following text describes a protein:
Function:
Probable methyltransferase; part of the gene cluster that mediates the biosynthesis of terrequinone A, an antitumor agent. The first step in the biosynthetic pathway for terrequinone A is formation of indole pyruvic acid (IPA) from L-tryptophan by the aminotransferase tdiD. The nonribosomal peptide synthase tdiA then immediately converts unstable IPA to didemethylasterriquinone D (DDAQ D), via condensation of 2 IPA molecules. The symmetric connectivity of the 2 IPA molecules is thought to arise by head-to-tail dual Claisen condensations facilitated by the TE domain. TdiB then catalyzes reverse prenylation by transferring dimethylallyl diphosphate to carbon atom 2' of DDAQ D, to yield asterriquinone C-1. Finally, tdiC and tdiE enzymes robustly convert asterriquinone C-1 to terrequinone A via a transformation involving regular prenylation at carbon atom 5, which requires elimination of the hydroxy group on C-5.
Sequence:
MVNRPYANMNDLANAVAESVQKYLDNSGQARNGLFQKTNNGERDIETERLALQHQLFHLTLDGKLQLSPLPSPVQSVLDIATGDSTWVHAFAEQNPSAYIVANDPSPTSKIPLGLSVIPDASDANEPWTYTRQFDFVHCRQHHRRLDEPRLFKQAFSSLTPGGWLEMQELSNPVTSDDGTLSENNPLSQWGRLLIEASKKMNRPVDNPAKYETWMREAGFVNCHTVAYNWPTNPWPADEKGKTLGLWNLYNVLQRFEEFSVALLVKVLGWEMDDAKTFLGNVKEELMNEGVHGYWPVYVVYGQKPAAPGSDVITDSE
The following text describes a protein:
Function:
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Sequence:
MHFFSHKKGELYAEDVPVKELINKFGTPLYIYSYGTLIRHIRAYEEAFCEVPHIICYAVKANSNLAILRIFAELGIGADIVSGGELFKALKAGIKPYKIVFAGVGKTDEEIEYALKNNILMFNVESEAELHKINEKAKNLKKVASVALRVNPDIDPKTHKYIATGLKSSKFGIPIEKALDYYKLAKSMKNIKVIGIHKHIGSQITETSAYVEALNKILSLYDQLANYDMEIEYIDIGGGLGITYRDEEPPHPKELADVLIPLVKNKKGKLIIEPGRSIVGNAGILVTKVLYTKETEQKNFIIVDAGMNDLIRPTLYGSYHEIQPVTPGKKEKIVADIVGPICESGDFLAKDREIEKVSAGEYLAVMSAGAYGFSMSSNYNSRPRVAEVLVKGDQYALIRKRETYKDLIRNEIVPEELL
The following text describes a protein:
Function:
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Sequence:
MKKEVIIALDFPTLEKTLEFLDKFKEEKLFVKVGMELYLQNGPIVIDEIKKRGHKIFLDLKLHDIPNTVYSAVKGLAKFNIDILTVHAAGGSEMLKGAKRAMTEAGVNTKVIAITQLTSTSEEDMRKEQNIQTSIEESVLNYARLAKESGVDGVVSSVLETKKIREQSGEEFIIINPGIRLAEDSKGDQKRVATPIDANRDGASYIVVGRSITGNENPEERYRLIKNMFEMGDKYVE