lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a GC-rich promoter-specific transactivating transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MAQHDFAPAWLNFPTPPPSTKPFLYAEKRSESLGRSDCAFNVNRQRHNSSEAFDSSFGGNLKKREKNVWRPQSRSAAEPTWQREASLHLYSSNLQRVNSQLRSERNTSEFDLTRSLDREDCKTFEAEDFSFLYPEHERGKKLFTARLWEYPMNAGSTSPQMLGIKKGLMDDFSLSGYSIGVGNQSLPDKHWAGIKKEECKSLSKDNNIGSFYQDCPPENYIPNTSLHAELLSVDPCSLEEEEDTHLNNRNDSCPEMDINLNFDENENSEDNVNTLISGQISPAYAQDGVLSSSLEAEFKLLREMGWQENDESCAPLTEDEMREFQAISEQLQKNGLRKHVFLRDALAFDLFQDAVQKEDSETSSSDTSDDE
The following text describes a protein:
Function:
Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.
Domain:
Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
Sequence:
MSKLTTGSFSIEDLESVQITINNIVGAAKEAAEEKAKELGPMGPTAMAGLASYRSWNLLLLDRYEPVLTPMCDQCCYCTYGPCDLSGNKRGACGIDMAGQTGREFFLRVITGTACHAAHGRHLLDHVIEVFGEDLPLNLGESNVLTPNVTICTGLSPKTLGECRAPMEYVEEQLTQLLATIHAGQESAEIDYDSKALFSGSLDHVGMEVSDIAQVSAYDFPKADPEAPLIEIGMGSIDKSKPLIVAIGHNVAGVTYIMDYMEENNLTDKMEIAGLCCTAFDMTRYKEADRRAPYAKIVGSLAKELKVIRSGMPDVIVVDEQCVRGDVLSESQKLKIPVIASNEKIMMGLPDRTDADVDSIVEEIKSGAIPGCVMLDYDKLGELIPKIAEVMAPIRDAEGITAIPTDEEFKVYIDKCVKCGECMLACPEELDIPEALEYAAKGSYEYLEALHDVCIGCRRCEQVCKKEIPILNVLEKAAQKSISEEKGWVRSGRGQASDAEIRKEGLNLVMGTTPGIIAIIGCPNYPAGTKDVYLIAEEFLKRNYLLAVSGCSAMDIGMFKDEDGKTLYEKYPGTFAGGGLLNTGSCVSNAHISGAAEKVAGIFAQRTLAGNLAEIADYTLNRVGACGLAWGAYSQKAASIGTGCNIYGIPAVLGPHSSKYRRALIAKNYDESKWKVYDGRDGSEMTIPPAPEFLLTTAETWQEAIPMMAKACIRPSDNNMGRSIKLTHWMELSKKYLGVEPEDWWKFVRNEADLPLAKREELLKRLEAEHGWEIDWKRKKIISGPKIKFDVSAQPTNLKRLCKEA
The following text describes a protein:
Function:
Possible SF3b-like factor.
Miscellaneous:
MISCELLANEOUS: Present with 1240 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MNYSADSGNTVYVGNIDPRITKEQLYELFIQINPVLRIKYPKDKVLQAYQGYAFIEFYNQGDAQYAIKIMNNTVRLYDRLIKVRQVTNSTGTTNLPSNISKDMILPIAKLFIKNLADSIDSDQLVKIFNKFGKLIREPEIFYLSNGKLKCAYVYFEDFEKADLAIKSLNNQLVANNRITVDYAFKENGKGNAKYGDDVDRLLNKEALKHNMLK
The following text describes a protein:
Function:
Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
Subcellular Localization:
Cytoplasm. Peroxisome.
Sequence:
MTIERELFVSAPGKVILHGEHAVVHGKMALAVGLNLRTFIRMRPRKDDTVLINLPNIGTKLRWDIAQLQTLLPSFQDDPQKLEILKNFAGIIEGCKDTESLAVLAFLYLYLSICGRDLPSVDIVVWSQLPTGAGLGSSAAYCVCLAAALLTYCGRIDDPMCDETTILRWSQTELDLINQLAFQGEKVIHGNPSGVDNAVGTWGGALQYQSGSITPMERIPVLHILLTNTKVPRSTKVLVAGVKEKLLKFPDIMEPVLSSIHAVSQECQRVLKEMTAGLSMDHYTVLEELIDINQHHLNVIGVGHSSLETICQVTKSHGLHSKLTGAGGGGCAITLLRTDTDHAVVETVKQELTNYGFQCWETSIGALGVSVHLPSSLTEDVREAFSNL
The following text describes a protein:
Function:
Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. Together with Nup54, required for transposable element silencing regulation in ovarian follicle cells. By interacting with the nuclear (Nxf1/Nxt1) and cytosolic (fs(1)Yb) components of the flamenco (flam) transcripts processing pathway, enables export and subsequent piRNA production.
Subcellular Localization:
Nucleus, nuclear pore complex. Note=Present also in annulate lamellae pore complexes (ALPCs).
Domain:
Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.
Sequence:
MFTPTTNNAIGGATAATGAFAFGARPATTTAPPPSFGAATSTPTFGAAPATTSLFAAPAATPAFGAPAATPAFGAPASTPGFGATSTAAPAFGTAAATPAFGIPAATSAFGAPAATPAFGAAAATPAFGAPAATPAFGAPAATSAFGAPAATTAFGAPASTQASAFGAPAPAVGTVAPTFSFATPATSAPTTAPPAFGFGTTATTAAAAMPASLSSGIGSFSFPKPQATTAASLNFNTTTTTATAQPFNTGLKLGTTNATTTLGGGGIFSKPAGQAAAPAASTFVGLGGIDVTATQPKLGDNKQDGIKIKETQVPDEIIKTVDGLKAYIKQQKTISSDIGRTSTSKFTNVSHEITNLKWALQNMATLVEGSNQQIRLMRQETVKAIQSLEMAQRTQDTPAGLQFENNAPFQYFQCLVAKYEQDLIAFRQQIALTERHMHAISNPQSISPDDLKRGFRQLNESFISLAGRLHEVHQRVEEHKEHYLNLRRYRLRDTTNVFERIDNPPLPTVEPQRISSGPTPFSNISALMNKSYAAAASSASNATGN
The following text describes a protein:
Function:
Directs gonadal sheath cell differentiation and function. Also directs gonad migration and plays a role in specifying the differentiated phenotypes of epidermal cells during postembryonic development. Plays a role in oogenesis, regulating a sheath cell signal that causes oocytes to maintain diakinesis arrest during meiosis. Negatively regulates oocyte maturation, ovulation and MAPK activation in oocytes when sperm are not available for fertilization. May be recruited by akir-1 to the promoter regions of antimicrobial peptide genes to control gene expression in response to fungal infection.
Subcellular Localization:
Nucleus.
Sequence:
MNTLENTFQFLAEVFEANGGCLVTERVSPSLSGASKRKSRPVKRIITEDEVIPEEEVVEEEEEEKVEQPSEEVTCPAMQVDATDAILASLRQIANNDLSEHCIREDEGNTSAEVFSNGNGEDMEQAGLAGTDLLRRVADMLQGNHNGSLNSHFLQQQFAAFKETVDPTPVSTNGNGLLTPITTQLSPLFTSTDAFNSPEKLLQAIMTPSLGFLGANGLGASNSGLLSSPLIAPSPTLLQSLMNTPTQPTASLTPKKAENRPPVVSQTLKASKRRLFDDTSRIEAASMSGDDRIDMNELEAFAQTFKKQRIKFGFTQGDVGVALGKRYGTDFSQTTISRFEALNLSFKNMCKLRPLLKEWLADVEMAIEGGATVTDLIDKKTIHNGNHHTIHHVDIHETSISNSISSVTASSLLSREQHVKRRRKRTNLDMNQRNALDTFFALNPRPDHDKMTDIANSLELDRDVVRVWFCNRRQKMRRVDEPIEGEMVTPSVSPVFPHFSSMSALEQIQEAARLASCQASNDDSDGTSGSPDAPSNDGCSDL
The following text describes a protein:
Function:
Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSLTVSDLTTELKKIIDSKNESALVQLTSQYASKHRDKVVINYKSIYGMYPADAIKKALKSGPAETLLMYAWTDAQEVRARLLNQALSGKNNKSALIDVVLFCGPEDWYEMGAHYTRIFQKVANDTLLSDIGSSEPWSQLIKGWIKHDRYERKAISEDAAALMGYLESGNPDGLIDLLCNTTEGEWKKINKVFTEKYGVEVETLIASNYVKTDMEALLTAHFYLLQPGYAAAYLCSLANSGKKGDSDRMVRITSLMFDKALKCKFAYEKYGKLGSDFKRLYDARLGRALCALWRVDTEGAN
The following text describes a protein:
Function:
Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds. May play a role in storage protein biogenesis.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MATTQPRRRIPYPPLISVCASLWWLAAAAAAASVHEFPTDGTVVELDDASFDRAISAFDFILVDFYAPWCGHCKRLAPELDKAAPVLAQLNEPIVIAKINADKYTKLAAKYEIDGYPTMKLFMHGVPMEYTGPRNADLLVRFLQKFVAPDISFLESDSAVQNFIDMAGANFPMFIGFGLNESVILELARKYKKKAWFSVAKDFSEEIMVAYDFDKVPALVSLHPKYNEQSVFYGPFEGEFLEDFIRQNQLPLTVPINSETLKLVKDDERKIVLTIVEDELDENSLKLVRILRSAATANRDLIFGYVGVKQWGEFVDTFDISKRSKLPKLLVWDGKEDYHIVVGSEDLDDNDQGSQISRFLEGYRDGKTIKKEMNGPSLIGFINSLVSIRTVYLIVFIVAVLMVIQNFSQTEENPQFRGIQDGAEGTDASTSHIKNRRDYQPGNKED
The following text describes a protein:
Function:
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
Sequence:
MVMGSAAGGRAGIVLAGGRSTRFGDREKALATLGGRPLLWHVVARLGTVVDSVVVNCRRDQRAAFRTAVTTTDTDVAFAVDPDPGQGPAAGLSTALNAVGEPVVAVTACDMPFIDPAFFAWLCDRRADAGCAGAVPVVDGHLQVTHSVLAAAPTRVAVDAAAAAGNRSLSGVVARLPVTQVPAAQTRHRTARHSFMDVDTPAELAAARERHRAPRAVDRAHDPGETGVSNAGD
The following text describes a protein:
Function:
Plays a role in the inhibition of host innate immune system by targeting host CGAS and promoting dissociation of DNA from CGAS, thereby inhibiting the enzymatic activity of CGAS.
Subcellular Localization:
Host cytoplasm. Host nucleus.
Sequence:
MGDKPTLVTLLTVAVSSPPPSSPLPLVSFTELLLPPPSVAAAAVAATATSEVGEKTAEQEVAAADPETGNERRENRENEGGETRTTGTTAVKRSHDGIPRQLAERLRLCRHMDPEQDYRLPAQDVVTSWIEALRDADRDNYGRCVRHAKIHRSASHLTAYESYLVSITEQYNTASNVTEKASYVQGCIFLSFPVIYNNTQGCGYKYDWSNVVTPKAAYAELFFLLCSTSESSVVLQPLITKGGLCSSMAVYDEETMRQSQAVQIGFLHTQLVMVPFVPHACPHYAVPFTTPGKPGCGGAPSGVAGLEEAAPFGRVSVTRHGATLLCRVDHLTWISKRVTTYGHKKITRYLAQFRGTMDDDEAALPGEDEAWIASKNVQYEFMGLIFTVNVDSLCVDAEQRQLLGTVATSFCHRVSDKITARNMPRAFSFYLLTSAQRGYDLRFSRNPSLFFSGDALNCPLLNEPNVFSLTVHAPYDIHFGVQPRQTVELDLRYVQITDRCFLVANLPHEDAFYTGLSVWRGGEPLKVTLWTRTRSIVIPQGTPIATLYQITEGDGNVYSYNHHTVFRQMHAAGTTTFFLGDMQLPADNFLTSPHP
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
SKMSNIVDFYKDRTLFITGVTGFMGKVLLEKLLRSCPGLKKVYLLMRPKKGHDIRTRLNQLIESKLFDDIRENMLNVHEKVIPVAGDIMEPKLGLSEEEEKILIEEVSIVFHSAATVRFDEPLKMSVQLNIIGVNRILDLCKKMQHLDALIHISTAYANCDRHLISEKIYQPPITASKIVSAMEWMDDEVVQALTPKIIQPRPNTYTFTKAIAEHLIAEKSENLPVAIVRPSIVGASWQEPLQGWVDNFNGPSGLLVAIGKGILRVMMGNNSACADLVPVDMAVNLIIASAWSTATYGHNGLQIFNCTTGLQNRLTWGQIEKASMDCFSRNPVDVPVRLPNPKFTLNRTYYLLQRWFDHFLPAWFMDIGLKLCGQKPILMRLQRRLWKSVSCMEFFTSHEWKFEDDNVRKLYANMSERDQKDFNFDVKQIHWPTYLENYCLGVKRFVLKEDMKNLLKARKAFYRLVGWLAGWLAGWLIG
The following text describes a protein:
Function:
May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found. May be required for rapid internodal elongation in deepwater rice during submergence (By similarity).
Subcellular Localization:
Secreted, cell wall. Membrane; Peripheral membrane protein.
Sequence:
MASSSLLLASVVVAAMVSAVSCGPPKVPPGPNITASYGDKWLEARATWYGAAKGAGRKDNSGACGYKDVDKAPFLGMNSCGNDPIFKDGKGCGSCFEIKCSKPKACSDKPVLIHVTDMNDEPIAAYHFDLFGLAFGAMAKDGKDEELLKYVAGDGDVVEVEIKEKGSEEWKALKESWGAIWRIDTPKPLKGPFSVRVTTEGGEKIIAEDAIPDGWKADSVYKSNVQAK
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MNSIKSLVNSFDKFYPNSTFDDSVISQINDIPEEEEEEGEDDRQKTLVPIKLQTDKSLTDSKDSLSEKHTQQVEIEEEDNNEEEEEEEEVDEEEEEEAEDDDEDSINLIEEKKKLDIDSAKSHHDEQFRSQTHQDQQSILFFIIIFILRCVIFLPNNLIIKPILYAYYIITFPIRYTTQQLGSTSYTLKTEDESQISPAIIPEEINDPFVTRANTKTTATTTTTTTNKPTPQEAELPSLDECYDKKTEQIKHNNFISNTMKSPTSFSKYMIPPPQRLFPLSRNPEKRRRKKILILDLDETLIHSLSRGSPRSFNPATASKMIEIKLNSISSLYYVYKRPYCDYFLQETSQWFELQIFTASVKEYADPIIDWLETEILDRQNKRSSNGSATTKSTTKTTTNQTKIFTKRYYRNDCTYRSGVGYIKDLSKFIKDEDLKHVMILDNSPISYALHEENAISIEGWINDQSDKDLLNLLPLLKSLSLAIDVRYILGLKNGEKFIE
The following text describes a protein:
Function:
Transcription factor which acts as a master regulator of biofilm formation. Biofilms play an important role in pathogenesis and produce many infections such as oropharyngeal candidiasis or vulvovaginal candidiasis. Controls the expression of genes that govern cell-surface properties such as ALS1, ALS3, HWP1 and HYR1. Down-stream component of the hyphal regulatory network that couples expression of cell-surface genes to hyphal differentiation.
Miscellaneous:
MISCELLANEOUS: Implanted medical devices, such as venous catheters, are a serious risk factor for C.albicans infection since they are substrates for the formation of biofilms, which in turn serve as reservoirs of cells to continually seed an infection.
Subcellular Localization:
Nucleus.
Sequence:
MSGTSQVLQNDSHQSQHASMAYNQRQPMMYPPPPQQQPLHSQNSLPPLPPIPAPSLPPISNNISNGNTNELNNNNQQQQQHGQPPLPPPPINANQQYYAVPPLRAPPPLNTLSSVVNSLPTLTPTLTNATHSTMSSNSSAESSASSSSNSITKPKSKRSSKGRVFQCTGYPGCNMSFTRSEHLARHKRKHTGERPFTCPYCSKNFSRLDNLRQHKQTVHAYETYLTKDNRDSKLLIERSKSKKKLKQQEKKAQQQAQLQAQAQAQAQAQVHMQQHQQNGYNFQPPYPQFHNQYYANNQYQGPQPPPPPAPQQQVPGQQQPQPQQGMPAGYLDPYRQYPPNTTFDPMALPPPPKINAHPQKPLPPLPHQMGGGQEQPSDNVSQQGLKIPDHAFTPKRRPEPLALQHSTHSNENISNEGNINANTNTNMNTVTSSITSDAVYPPPPRSATSAASLTPNLASPLSPLFHQSFSQTTLKSTPDPRGSTITNSSISIKSPMSQHFSILSGNSNYSNNTTNSLPSVSNLPHPNWGSTNGTTGSNGTSGGSYQQNSFHQRQSSVVSDFSIFSNSDNRKDIKSNWLKGVLNDDNNNNNNNNNEQQQQQLQDPKLASPAPTLPPVSSITGGGTSNGNDSMMVDNMENKNDVSQSNVIIDSNNNNGDKMVNKLNFQSIELHDNNNNNTPSIKSTHSTETIQTTMVVVNKSDPPPLSTPTTNTNTNTNSTATTNATGYVSKKPTINNLISQ
The following text describes a protein:
Function:
Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates [4Fe-4S] cluster insertion into a subset of mitochondrial proteins such as lipoyl synthase (LS) and succinate dehydrogenase (SDH). Required during the last step of iron-sulfur protein assembly when the iron-sulfur cluster is inserted into the target protein. Probably acts together with the monothiol glutaredoxin grx5. Not required for [2Fe-2S] cluster insertion into mitochondrial proteins (By similarity). May be involved in control of cell division, especially during the resumption from cell cycle arrest.
Subcellular Localization:
Mitochondrion matrix. Cytoplasm. Nucleus.
Sequence:
MIRRFFHTMGRQDRIYKTLSEALKTDKITLYNDSYKHSHHIAMKGVPDTNETHFRLEIVSPEFSGMSRVARHRLVYGLLKDEFDGGLHALQITSSKTPDEVS
The following text describes a protein:
Function:
Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
Has 16 transmembrane helices and a cytoplasmic domain that contains the active site. Pyrophosphate binding is thought to trigger a conformation change that allows Na(+) release. Has at least two binding sites for Na(+).
Sequence:
MYVAALFFLIPLVALGFAAANFAAVVRKPEGTERMKEISSYIRSGADSFLAHETKAIFKVAIVIAILLMIFTTWQTGVAFLLGAVMSASAGIVGMKMATRANVRVAEAARTTKKIGPALKVAYQGGSVMGLSVGGFALLGLVLVYLIFGKWMGQVDNLNIYTNWLGINFVPFAMTVSGYALGCSIIAMFDRVGGGVYTKAADMAADLVGKTELNLPEDDPRNPATIADNVGDNVGDVAGLGADLLESFVGAIVSSIILASYMFPIYVQKIGENLVHQVPKETIQALISYPIFFALVGLGCSMLGILYVIVKKPSDNPQRELNISLWTSALLTVVLTAFLTYFYLKDLQGLDVVGFRFGAISPWFSAIIGIFSGILIGFWAEYYTSYRYKPTQFLSKSSIEGTGMVISNGLSLGMKSVFPPTLTLVLGILFADYFAGLYGVAIAALGMLSFVATSVSVDSYGPIADNAGGISEMCELDPEVRKITDHLDAVGNTTAAIGKGFAIGSAIFAALSLFASYMFSQISPSDIGKPPSLVLLLNMLDARVIAGALLGAAITYYFSGYLISAVTKAAMKMVDEIRRQAREIPGLLEGKAKPDYNRCIEITSDNALKQMGYPAFIAILTPLVTGFLLGAEFVGGVLIGTVLSGAMLAILTANSGGAWDNAKKYLEAGNLEGYGKGSEPHKALVIGDTVGDPLKDTVGPSLDILIKIMSVVSVIAVSIFKHVHLF
The following text describes a protein:
Function:
Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
Subcellular Localization:
Nucleus.
Sequence:
MPGEEATQLVTLSDISNEHVTEDINKEKREATAHLDPKKEETKTIQGKEDEPAVSLSACLCHKGVPEGWERIVKQRQAGKTAGKYDIYFVSPQGKKLRSKHALLDYFKKNRETGLKLEDFDFTTSVQNNKQRTKESSIVLGRLKEERRVTRSQILDIGLQSNEGEELQNEIVAFQTNAGDLENISTSLQTETVADDNSKDCCFKSKENVKIKKARKSSENRYLEDGPNKRLRASSHKKQGVGKLPKTRRKKAAYIPCLKDEIPLSQPELEPHVQPVASLLEHKSSADHFNCNVGPRGVVTVAPNENLSGLEMQRNLMLPGNQGVKIALSMEVSQTCDETCFTSIKENHIRRRKTSPYFSSKLTKIAPSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNKTSGKMAIPVLWEFFKKYPSPSVARTADWKGMSELLKPLGLYELRAKTIIRFSDEFLVKRWKYPIELHGIGKYGNDSYRIFCVNEWKEVQPKDHKLNIYHAWLQQNYEKLKLNDSK
The following text describes a protein:
Function:
In the mosquito vector midgut, plays a role in ookinete development.
Sequence:
MNRTHMPNNHKIHEGINMKSSINEVKKSKRIEKELSYVTNSTKKKSKKKQTNIKKIGDVSVNIENINIPNNLNLYTDNESVVSSKYKKKKKKKKKLNIYNNNDNSKYLKPQVVKKKNSKIIFLHHNENNTSTHSGESSKFQKLKKKKKIKKGTKKKSINKISILKHKSHESFPSTQNENTPELEPKQVNLSPLEIEINKTNDIDKHGLEINKTPSTQNFNDPINNLDNNEKIKDRGLFHGIDNIYENYITNDKENMQSVIKNRHYIIDKNEQNEQAYNNDMNITNFIKNGNTNKNSNNDKSANSNDYNKNLFCELTEAIENDGIEQTCNRNINIRLKEEKEAEEEERKKNEDEHILENGKSNNEDNSFDKKDDLTNLGKSFKNNESFELNSPQKNIRKGSLDGMRKKKISEKKMKTKIKQKKKRQNNINDTTIGKKKIYIKENNNERKSSGLILGFKKMKKKLSGKRIDQKKEYKEKEIYSDKLKDVIKDKKKYKKKDIDDISFTKDIVKENVKGVDRDDDEKKRKTIGQDEEKEKIEIIIVKKNETGTEEEIKVETDENPKVKTKEKCKIENGEGCKIAIDEENSVFVEAENMKNEAKLEADVIIIEDAELRKDEEEDKSKNNEKDSKSEERDILETQMAGKEEKPVLKKKKKNKGKQRNREGKGVVEKGYDAKREKKENEEKNKANTKMEPNDSIEQKDKLSNVQNMSNIVKNNKVNKILEKYIISKKEENLKRKYMNTKKFMDILDISEKKFKIDTINFFPHTIGQVCYSDIYFFFDTYEKELKKSNTGKNTIKLMKKLFKCEYIEMNNMELILQIFDKIIDKLKKELKTESIVKIYDEEEHVIASKIMKYKNGNYDKYMYNKKKYDSNNEYSISENNLFNQNPLHHQNNLFGCNRNKLYNIIFNSSQGEYIMGSHSFLILQQWNDEYKLAMLRDKLEQIKKRKQNMNDPIAKYIKSLKYGFIDSLFSICCLYDCKKNDNDASYCDFPLPSQNTFYTNTQIHLDNMNLNSERILPMKITKAVQILASS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MYTNIPQQQQNIPQQQQQNIPQQQNVQNIQQPLPHTNIQQQNIQQQQQQYQLQFQKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQQQRPQTPQQNAQQQSQQSQQSQQQQASLGQGQQGSGPNTPPQSQPETIESIFKQLDLNSTGQQAKDILEQCKLKIHSLESQQLIAQAKYKLFSLAANYQSTVFQHIKMVSTTTTPTSTPTTSTTNTPQNSNTSSSSSTGTSSSTIGSSSSSTTTSTTNNENLGLPISKEIYQQKIQLWISIITFLRENLQYFGKWRESIYISIQNITQSTLLPTLIQKEFFTELFILLKSIFSFVNIEFPHYIALKEVKLSNTHQCLEYQNLIEPYYCRAAKLSSLLSLSSLSSSARIVGSSILLNQDAMIGYTNQLTESPPFFTSNRLLNNKYSTIVHHLLSQSASIEPIKELLFPQVQSNTLKSKIISIITEATISKTMQLLNKYPNQIIENQIENNSWKEWLLFSEQFYFLCENGLVDLEQFIVTLSEKRMNNGDPIKDNMVVLLISKTIIIQDVKTLFKQHLQNVNSNHYGHLIPLVLSFVNNDSNYPIISQNISLYFFLMRINTNTENPEIIAHIKKLLDNFNFQFTLFQQYRNWWESEKVKQKPEFFTTIQDITYFSIICNVIPTEGEMELIRFQSNGSDQSIQFPGVGGIGTVVTGKIKPVSNLILLNLSLRCRRKLIQESVLLLLDKEVPISPGFLEDYCRTVHYTPGPVSPFLFSYFKKFHRLAPIHAVIESVSHRLLKVLKSNKELAVLLRALQDIQTQKPIQNIQLSRSIDYLLLKASISLPVDLISAKEIWKSLDLGLFNNRRLITSIARLIKLKGIQDFNRISDVPVFIENCFKSNPYCFSKSTLEFFPDILKNEFKKNSENLSLNPNQFTNLTLMKPPTLQKVQLENQQRFQLFSVGGKLQILQKQALVQQYLTDNNSNLLLCQVFIYMLENKIKMDVMGPLIQQMFFKQIIGNQQPQQQQQPQQPPPLAISNQQLNRITSVFIDFIFDEVYVNHPLKQENLHQHVSEFLCQSIFTYKILTLNSVLLALLDRDDHPSMPTILDTFLFSSAEIQNRLQFFSTYPSDFFISQSFRNDDNYFIKNCEFNNRFNDLIPTVIDPNTLIEQSTQDTILPIYYSNSISRLMPIVEIIISKSIELNNGDLFEKTINHFNIPYHYYQDEKETTIKDTLIYYYDSQLFKLNPELKLLFLKLLNQSDIDNRFSNIFNQFLKSSRIEDITMVGSTAYFNDLISPLAEMMDLTNQNVFDTFSFKTENTFSSIDISNPLELKLNNIILEILLLPLDSNWIANGLVSLLNYSNRNKNFSDRKIDPPSSSMVLALSIIFSILPTQIHNSFIPIVTQNLSNELNFSKFKSPIMKNQYNFGNYTTNVEEKMTEPIEWYIYFIQFYYLYCPLERLLSLNDLVTNIRPLIKNVYQYYVLLTIVSPVLLRFGTQTNHLIQITREMLQILTDSYLSSYIENTLQDLESCWIGNTNDDDDIMDTTNFNLFGKRIGYDDDDDDEDDDYYDEDDEDEDDDNEDDQQDENDRMDFSQDTNNIFNRSMGDHDHLMMMSNSENLNDPWSDKNEFFRKQKSIFLKIDSQLIDTIIDWIYHIKMIFPFQPFRDELLRIVKEFKPNFLSKFNQLN
The following text describes a protein:
Function:
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP.
Subcellular Localization:
Nucleus, gem. Cytoplasm. Note=Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
Sequence:
MAAVKASTSKATRPWYSHPVYARYWQHYHQAMAWMQSHHNAYRKAVESCFNLPWYLPSALLPQSSYDNEAAYPQSFYDHHVAWQDYPCSSSHFRRSGQHPRYSSRIQASTKEDQALSKEEEMETESDAEVECDLSNMEITEELRQYFAETERHREERRRQQQLDAERLDSYVNADHDLYCNTRRSVEAPTERPGERRQAEMKRLYGDSAAKIQAMEAAVQLSFDKHCDRKQPKYWPVIPLKF
The following text describes a protein:
Function:
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
Sequence:
MRIVFAGTPDFAVASLRAAAQRHEVVAVYTQPDRPAGRGRGLTPSPVKLDAIARGIPVFQPQTLRSPEALATLRALQPDLMVVVAYGLILPKAVLAAPTHGCWNVHASLLPRWRGAAPIQRAIEAGDTETGVCLMQMEAGLDTGPVLLSQRVEIGEQETGGQLHDRLAALGAQVLSDGLGLLRAGIRPVAQPQPAEGVTYAHKLDKAQARLDWAQPAEELARRVRAFNPWPVAEAILAGERVRLHGAVALDLAHQQAPGTLLAASKQGIDIACGQGALRVRVLQREGGKAITAADYLNARRDLPALR
The following text describes a protein:
Function:
Involved in microtubule formation, polymerization and assembly, regulating microtubule nucleation and length. Plays a role in pronuclear migration and mitotic and meiotic spindle elongation during early embryogenesis. In complex with zyg-9, functions during the early stages of embryonic development to regulate microtubule assembly throughout the cell cycle. Specifically, the complex is required for the formation and growth of astral microtubules and spindle microtubules during mitotic spindle assembly. At anaphase, the complex is required for mitotic spindle positioning in one-cell stage embryos. The complex acts in a partially redundant manner with the tac-1/zyg-8 complex to regulate microtubule assembly and processes during interphase, mitosis and meiosis in embryos. Plays a role in injury-induced axonal regrowth, regeneration and microtubule stability in PLM neurons and this may be downstream of efa-6.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Chromosome, centromere, kinetochore. Cell projection, axon. Perikaryon. Note=Initially enriched at meiotic spindle poles, but then recruited to the sperm centrosome. Localized to centrosomes early in pronuclear migration. Centrosomal localization is dependent on air-1, tbg-1 and zyg-9 and is also controlled during the cell cycle, with high expression during prophase and metaphase, but with expression reducing from anaphase to telophase. Accumulates at the centrosome during interphase, ready for the next mitotic cycle. Cycles between cytoplasm and centrosome during mitosis in a cell cycle-dependent manner. Diffuse localization along the axon and localizes to perinuclear spots in the perikaryon. Following injury co-localizes with efa-6 and ptrn-1 in puncta of the perikaryon. The zyg-9/tac-1 complex localizes to centrosomes throughout the cell cycle and the kinetochore of metaphase and early anaphase chromosomes.
Sequence:
MSLNTTFTKEDGTEVVIPFNGSQNGHPENEEPEVEEAAEPSSSVETLCGATRGDIIVMKHTTKALTELIERLLHSDEFEVRRCSNGQIISQGRCNGTTPGNGIGGGGASSEELEKALKDRDAARAEADKLHANYATLFASFNTVREAANDIRGEYEDARDKLKLAAAEVDEWQAKFLAVKDNANSELERASVEYDDLLRSHDENTKGLRLRVKRQEIELSSKNDEIKVLTNRVSELSQICDQLLNDVDVSDGMSVISTDA
The following text describes a protein:
Function:
Involved in cell wall beta(1->6) glucan synthesis.
Sequence:
MRAASGFGVVLWLLMQAVQLVWADVSVLKPEKGARFSAKSGKASLELRWRIDETTYPKKDEIEIYNVTLCGGPLNQLTCMMNLANDVLPADVKEDNGELSLDLTVDANIVADGMYMVQLTANAGIMGYTINYSKRFYLEDMTGPKKITVSAPLDHPLWGEVHITARKDGVKFDPTAEYASVPYLSQTAKTRYAPMQTQPATKISATTWVNKHEVTSVSYFSVIRNDLLFQETTITRSIDYTLSLFHNYATPQPHPSEWYDPKQRQTLSTRKINLSHLSKR
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
Sequence:
MSTSQEKAQNQASQARKGDCQIAIIGDEDSVTGFLLAGIGSIDRMKRTNFLIVDNKTQHDKIAQTFNEYVNRTDIAIVLITQNVADSMRDILDGYDRYLPVIMEIPCKDHPYNPDTDSVMVRLKRMTGRD