lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane during regulated or polarized secretion. Involved in polarized cell growth and organ morphogenesis. During cytokinesis, involved in cell plate initiation, cell plate maturation and formation of new primary cell wall. During cytokinesis, involved in cell plate initiation, cell plate maturation and formation of new primary cell wall.
Subcellular Localization:
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, phragmoplast. Secreted, extracellular exosome. Note=In interphase, SEC3A localizes to the cytoplasm and plasma membrane, where it forms immobile, punctate structures. Localizes to the early cell plate and completed division wall during cytokinesis. Shuttles from the cytoplasm to the exocyst-positive organelle (EXPO) in the presence of EXO70E2.
Sequence:
MAKSSADDEELRRACEAAIEGTKQSIVMSIRVAKSRGVWGKSGKLGRQMAKPRVLALSVKSKGPRKKAFLRVMKYSSGGVLEPAKMYKLKHLSKVEVITNDPSGCTFTLGFDNLRSQSVAPPQWTMRNTDDRNRLLVCILNICKDVLGRLPKVVGIDIVEMALWAKDNTPVVTTQRSTEDGEPVAESVTESDLKVTVEKELVSQAEEEDMEALLGTYVMGIGEAEAFSERLKRELQALEAANVHAILESEPLVDEVLNGLEAATNIVDDMDEWLGIFNIKLRHMREDIESIETRNNKLEMQSVNNKALIEELDKVIERLRVPSEYAASLTGGSFDEADMLQNIEACEWLAKALRGLEVPNLDPIYANMRAVKEKRAELEKLKATFVRRASEFLRNYFASLVDFMVSDKSYFSQRGQLKRPDHADLRYKCRTYARLLQHLKGLDKNCLGPLRKAYCSSLNLLLRREAREFANELRASTKVSRNPTVWLEGSTGSSQNANTDTSAVSDAYAKMLTIFIPLLVDESSFFAHFMCFEVPALAPPGGAGNDKKSQSNNDDGNDDDDLGIMDIDETDKKPGKNSPDLTALNESLQDLLDGIQEDFYAVVDWAYKIDPLRCISMHGITERYLSGQKADAAGFVRLLLGDLESRVSMQFSRFVDEACHQIERNERNVRQMGVLPYIPRFAALATRMEQYIQGQSRDLVDQAYTKFVSIMFVTLEKIAQQDPKYADILLLENYAAFQNSLYDLANVVPTLAKFYHQASEAYEQACTRHISMIIYYQFERLFQFAKKIEDFMYTITPEEIPFQLGLSKVELRKMLKSSLSGVDKSIAAMYKKLQKNLASEELLPSLWDKCKKEFLDKYESFVQLVAKVYPSENVPGVTEMRGLLASM
The following text describes a protein:
Function:
The most abundant DEAD-box RNA helicase. An ATP-dependent RNA helicase with RNA-dependent ATPase activity. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. In vitro, unwinds dsRNA in both 5'- and 3'- directions. Plays a role in ribosomal 50S subunit assembly. Its deletion leads to changes in mRNA levels for over 200 transcripts.
Subcellular Localization:
Cytoplasm, nucleoid. Cell membrane. Note=Shows transcription-dependent localization at subcellular sites surrounding the nucleoid. Associated with free 50S ribosomal subunit, 70S ribosome and polysomes. Cell membrane association shown in.
Domain:
The C-terminal half of the protein (residues 225-494) is required for interaction with most RNA degradosome partners, whereas dimerization or oligomerization only requires the extreme C-terminus (residues 413-494). Addition of the latter domain to CshB confers on it the ability to interact with Rny.
Sequence:
MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVIGQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKVLPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNMGFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQFYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLTQAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGRAGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTISENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRSSKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY
The following text describes a protein:
Function:
Cleaves at paired basic residues.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Secreted, cell wall.
Sequence:
MRIWILIFFSFIKLVSSLQYTGNGVLALDFVAKTFPNQENQLEKRDYTYSPSGITSFPLDLQSYTYYTTTLSIGRPSISYTVAIDLDMPYTWLTYYNVMAFNPAYLGIVNSGTQWSTDELRYFLCKKESDSCYFGNASSSFHFVTSPSTFFIRYDDNITVAGINVQDSLSYSHYQALPDFQFGITLKEYVPSSMLPYKGVLGLAASTEINSIDYSDSISSFSPPTFLEQLVKEDILAYPAFSMYLDNQGNGSLLLGAVDTSKYQGQFVALKQTKLTHYAVSIYSVQFLNSTFFSNYSIITDAYFQTRETYIYLPAELAYSVMDNAGAYLSEGYFALNCDEIDLEAALIFQFGCNSTIKVPISLLVIGQVSNICLLGIRPSTDSEIVLGLLFFRNAYTFYHQSQKMIAIGQAFYNATSNLSAIVDQHIPGALTCSQYPTSVASTQLVQTSHFTSTSLSAVNISESVVYSYTSSSSMPSSAIPSFNISLISQNAVANAGNSFSPLSAMVIMMMSAVFLGLGII
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit polr2a, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MKVHCLSQSAQSPCFLLEYKNVKILLDCALEISSILHFLPKNLNYNNNNNNNNNNNNNNNNNNNNNNNNNSYSFKEKDKELNQFFKNINGTLYIDNGCSNIKYNCPQFEMIDDFSTIDMILISNYTNIYALPFITEYTNFQGKIYATEPTVQIGKLLLEELVQMDKQYSNSSINNNNNNNNLSDCWQNIEILEKLNVHNVGMENENLYRDSYRWKDLYKKIDIEKSFEKIQSIRFNESIKHYGFECIPSSSGYGLGSANWVIESKGFERVVYISDSSLSLSRYPTPFQLSPIDNPDVLILSKINHYPNNPPDQMLSELCSNIGSTLQQGGTVLIPSYSCGIILDLFEHLADYLNKVGLPYVPIYFVSSVSKAVLSYADIYSEWLNKSKQERAFMPETPFLHQDLMRKGQFQAYQHVHSNFQANDPCIIFTGHPSCRIGDITTLIKLYDNPKNSILLIEPDFDFKSTVLPFSKQISRIQFLPIDPRINFNEANLLISKLSPKHLIIPRIYKNYVKNKHSNGNFGIVTTILPLDTIKIQNNQNFESGFIDKELAQTIQTKVLDKSSQLKNNTTTTTTTTINNQQPIHVAEISGVLSMSDHELIISPPNISDSNKIIHIKEKFIWGTLSIENIIKAINSTKQFKNNGDSIEYFEINENYYLIKISSKNKTNNNNNSDQVTNIHLSPQNVNIETSCETTRRLISDIVLLNCNGFYV
The following text describes a protein:
Function:
Potential monoatomic ion channel gated by mechanical force, implicated in normal touch sensitivity through the generation of mechanically activated currents. However, a direct channel activity is debated and an alternative could be that it functions as a chaperone for an unidentified mechanosensitive ion channel. Could also be involved in cell mechanosensitivity regulating cell adhesion and migration. May also be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MAAASFQPLKCLLLWVFFVITPPVKAVPEPGIWTVPIGSGAGSLFFRKTLYNSTNIKVKLISPNCPTPVKLTVKWYLRSHRCYNQFTNLEEVLERHHTNLDTTDNFCKNVSKPDFCDKNEDKNIDCNKDMHALPTLKMSKLVPKISVNQSAGSKNPLNQMDFDIVARTYQDGPYLFVLQVKGDENVKWNLSVTVSMKGPHGFISASDWPLMIFYMVMCIMYILLALLWFIWSACYWKDLLRIQFWIAAVIFLGMLEKAVYYAEYQNTDNTGVSSHGLLIFAELISSIKRTLARLLVTIVSLGYGIIKPRLGAVMHRVVGMGVLYFVFAAVEGVMRIIGAKEYDLVLLAGIPLALLDSGLCWWIFVSLAQTMKTLKLRKNTVKYSLYRHFTNTLIFAILASIIFMIWRTKKFQLVDCQADWMELWVDDAYWRFLFFIILLVIMFLWRPSANNQRYAFTPLIDDSDDEVEEFLVTDHLAEGMKLRGTKPECNGAPKPPATNIDEDLKWVEENIPSSFADAALPVLMDSDEEIMMTKYEMSKIE
The following text describes a protein:
Function:
Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (By similarity). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes. Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (By similarity).
Subcellular Localization:
Secreted.
Domain:
The mature protein is largely unstructured in the absence of a cognate ligand.
Sequence:
NMATCATQHLANFLDRSRNNLGTIFSPTKVGS
The following text describes a protein:
Function:
Golgi matrix protein playing a role in tethering of vesicles to Golgi membranes and in maintaining the overall structure of the Golgi apparatus.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Note=Probably located to cisternal rims of cis or medial Golgi.
Domain:
The C-terminal domain (508-668) is necessary and sufficient for Golgi targeting.
Sequence:
MANWISSKLKAAETILQQLDQQAADSLRKDEKSETHDEVFETSPKSGSSPVSLKDQLRKKTYEGSDSGSGSQRNSTEQKPSYLSSSKKVRKPDQSHERTSAPSQSLTQDNTKLTDNDWTELLSTPNQRTSTSTSRSPGGTSAIRGLKKDGKRHGNLGKNPLVSDGKKSSSSNVVNSRGRPQKQTNKEPSDKEVSSPSDADMKNRNAPRDIFVNSTHKESEKDVSGKTPPLDDSRRSANETLPRETSPSVGKRDGRESRRSSVWGKQVREEVSQSNVSDGLTRKESSLSSDESESDYESDSSTDSERERQREERRRRRERVFAEKVATKAVAVIKERENMVARLEGEKLSLEKIVEERAKQQAQEAAELQTNMMETLEAADLEKQKHNNTRMEVLTRLAGLEAENAELTRSLAAGQKKLETQIDQVAVLKQQVELKESTLEELKRNTFNIGGRGTTLKQLDTSRGDKFEHQMLEAEISLLTDKIGRLQDKATKLEADIEMMRKELEEPTEVEIELKRRLNQLTDHLIQKQSQVEALSSEKATILFRIEAVSRLIEENKGMSATEASSQDLEAGDWELSGSKFKPAFQDKIRSGKKHLGWLVMQLNAIFISGTVFLRRNPTAKIWAVVYLVCLHLWVLYILLSHSDASSSGELRSGAVISLENFSNSSLQ
The following text describes a protein:
Function:
Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
VEMYAVQPPNTGIQHRENTCKANVNNTDFGQGTLFIAESELIWIGSSNQGFRLQYTDIAIHAISTDVQSFPEECLYVMYNKGLFTSSQSENESDSDGEKDTTVSEIRFIPTDKNNLKRMFDALSDCQCLHPDEEDSDFFHEGEVNESPVQTFDGGAAGEGFFTGDAAIDHMTPQGLATMQRLEAMLAQQGSPSTDTGIETDMNGVHITEQQNGTTEDGQFDDA
The following text describes a protein:
Function:
Plays a role in determining ER morphology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.
Sequence:
MVSLWPWKGEDNSPAFFEKALSALSTKITQTTSQLDLHRQHARRFKALWTLYTTFAYLLYSIILALVLGWQNWGMTEYAAIIGGPVLIYVVRAVASKFFDYRINKTQRHLEDLQKQRDETIEKLKVATKYNSTQQLLEKYGAESPKPSRPKGGDEKRKTDAKRKQPSTPQQPVMRTGLPPPPTANIRRPTPAQSPVSSPGQPQSPPSYLIQEQPQLQNSHPPVPPALDEPGFAPNAFPSAPQYVEHSHWYDRLLDILLGEDETQPKNRMALICATCRLVNGQAPPGVKTLEELGRWRCGSCGAWNGEESEAKKMLAGMRDQARSADGAWESVAKPDSDSHSAGDATDEAVMVATSEDEQVEARSSGEESQNEADQQPQEQETPEASGNSKSGRGRRKGTRKG
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MGKGRIFQAAKVYQRASEAAATNIVSGLPPRNPPLWLKAIESIPPAEINTRPYPIQHSPPNPRARKPRNLFRPTKIVYPEDELRRDFYRDHPWELARPRMIIELDGKDARFLDWSKGLRQRGIPLSGESVVQRQLWLMENQGMTKQEAYDKARHEFYKLRQLEQMERRIAVEEARMVGGYFGKDLLTVGMELENKTYESWKKWATTEIARQESARASMYTNVVDNSALEESEEDELLAQN
The following text describes a protein:
Function:
Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MSSTKSIPADVIAKLQKFDELITKLEDAVEEVDVGVEKHFERSAHEMALVDTMSMFLMDSLMWAVQATKGGGADKNDDLLIDLARTKRMTADMKEINLRQDAPRINKQAAANFVRNALWEQPEQGESSKKAAK
The following text describes a protein:
Function:
Transcriptional regulator that interacts with cellular elongation regulators to inhibit host cell transcription and promote viral gene expression in productive infection, mainly by mediating changes on the host RNA polymerase II. One change, which is UL13 independent, is the rapid loss of Pol II forms bearing Ser-2 phosphorylation in the heptapeptides of the CTD leading to unproductive elongation of pol II. A second change, which is UL13 dependent, is the appearance of an intermediate form of Pol II that differs from the normal hypo- and hyperphosphorylated forms. These Pol II modifications immediately inhibit host genome transcription, leading to cell cycle deregulation and loss of efficient antiviral response (Probable). In opposition to its role in productive infection, inhibits transcription elongation of early viral genes, which can be beneficial because it reduces antisense and intergenic transcription. This regulatory function directly or indirectly helps to retain Pol activity on the viral genome later in infection. The viral protein VP16 overcomes transcriptional inhibition by ICP22 to promote transcription of IE genes. Recruits FACT complexes to the viral genome by interacting with the FACT complex, which could allow Pol II to cross the nucleosome barrier on the viral genome and achieve efficient viral transcription elongation late in viral infection and ultimately infectious virion production (Probable). Plays a role in virion primary envelopment, possibly by interacting with and regulating UL31 and UL34. Essential for the recruitment of Hsc70 into virus induced chaperone enriched (VICE) domains in infected cells. May function as a co-chaperone (J protein-like), functionning together with Hsc70 to recognize and manage aggregated and misfolded proteins.
Miscellaneous:
MISCELLANEOUS: ICP22 and protein US1.5 mRNAs are transcribed from two different promoters on the US1 gene.
Subcellular Localization:
Host nucleus. Note=Localizes in small nuclear bodies early in infection then moves to a more diffuse distribution in viral compartments as infection progresses. UL31 mediates the recruitment and anchorage of ICP22 at the nuclear membrane.
Sequence:
MADISPGAFAPCVKARRPALRSPPLGTRKRKRPSRPLSSESEVESDTALESEVESETASDSTESGDQDEAPRIGGRRAPRRLGGRFFLDMSAESTTGTETDASVSDDPDDTSDWSYDDIPPRPKRARVNLRLTSSPDRRDGVIFPKMGRVRSTRETQPRAPTPSAPSPNAMLRRSVRQAQRRSSARWTPDLGYMRQCINQLFRVLRVARDPHGSANRLRHLIRDCYLMGYCRARLAPRTWCRLLQVSGGTWGMHLRNTIREVEARFDATAEPVCKLPCLETRRYGPECDLSNLEIHLSATSDDEISDATDLEAAGSDHTLASQSDTEDAPSPVTLETPEPRGSLAVRLEDEFGEFDWTPQEGSQPWLSAVVADTSSVERPGPSDSGAGRAAEDRKCLDGCRKMRFSTACPYPCSDTFLRP
The following text describes a protein:
Function:
Probable serine protease inhibitor.
Sequence:
RRRQLRRHDGLRAPSGEASRRQRRRRQQQQKPRVLAGVPVRRAGAGGGRGTGHHPPRAPRAARRIVARRPRGVRLPRRGGRPRQRVVRVRRAARLLRLRRLARRDARAEAGLPRRRRRHGGTYKAVTRAANFRRQPKKSRKKINEWVSKATNKLIPEILPDGSVHRLTTLVLVNAIYFKGKWSDPFPRESTTTGKFHRLDGSSVNVRFMRSREDQYIGFYDGFNVLKLPYNGGL
The following text describes a protein:
Function:
Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.
Sequence:
MAQALGEDLVQPPELQDDSSSLGSDSELSGPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSERDLQREIKAQLAQLPDSAPGPPPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVPRIVVQPPEEPRPPRRKPQTRGKTFHGLLTRARGAPIEGPPRPQRGSTSFLDTRF
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
Sequence:
MASTDTISDMLTRIRNACAVRHSTTQVPTTKMTLSIAKVLKSEGFIEDYSETGEGINKMLVLTLKYKGKTRQPLINTLQRVSKPGLRVYSPSKKIPRVLGGIGIAIVSTSHGIMTDREARRQGIGGEILCYIW
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MESVTDDKSASSEVEILRANLSDDVAAGQWVEDYGLRTNTSWIVDFIKSTYRCQRMVFHKTWRCSQRKRSKVRGNPGADCPAKIDIKIKKITKNTKKTDPLLRGDMPLPAVIKLIHQEGHTHSTDPADAPRRLRPLTETKRRFQDYFDNGMCPAEAIRLHESKLLVQEGGYALLANGAVNPLPSSVYYWFRLWRDQCLSKDVDPLKKLLQKMTPAYPEQDDDGHAGLEETNLTPKARKNVRFKCCFCKYGSEEPRSMAAHLPTHVEPQFRCQHCPRVFPRKDNWIQHTMVHTGERPFKCPVCPAGFRRKRALRDHERSHTGERPFQCRQCLKSYGSLSTLQSHARRHRETKPHACYVCEKTFYNKWECTSHIRIHTGEKPFRCEHCPKAFTFKSALTSHTRQHTREKPFECQLCFKTFINSSNLNRHIQTHGQELSQVLQTS
The following text describes a protein:
Function:
Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane. Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse.
Subcellular Localization:
Postsynaptic density membrane; Multi-pass membrane protein.
Sequence:
MSAKERPPKSKVPTKESVTLLPCFYFVELPILASSVVSLYFLELTDVFKPVHSGFSCYDRSLSMPYIEPSQEAVPFLMLLSLAFAAPAITIMVGEGILYCCLSKRRSGISAEANINAGGCNFNSFLRRAVRFVGVHVFGLCATALITDIIQLSTGYQTPYFLTVCKPNYTSLNVSCSENSYIVDDICSGPDPMIINDGRKSFPSQHATLAAFAAVYVSMYFNSTLTDSSKLLKPLLVFAFIICGIICGLTRITQYKNHPVDVYCGFLIGGGIALYLGFYAVGNFLPSEDNMLNPNPHREPLRSLTDLSQDASRILPGKNSSSNDAISTHHPESMLNRNHRETGSLTNLKRANADVEIITPRSPMGKENMVTFSNTLPRANTPAMEESARRNATIHASMDSARSKQLLTQWKNKNESRKLSLQVIETDSGQSPPRAIEMRSSSEPSRVGVNGDHHGPTNQYLKIQPGSMPGCNSAGLSGGPRVSIQSRPGSSQLVHIPEETQENVNTSPKTSSARAKWLKAAEKTAGCRTNNQPRIMQVIAMSKQQGVLQGSPQSSEGSTVTCTGSIRYKTLTDHEPSSIVRIEAHPENNRPIIQMPSEGEGSGSWKWKAPEKGSLRQTYELNDLNRDSESCESLKDSYGSGDRKRSNIDNSEHHHHGMTTIRVTPVEGSEIGSETLSISSSRDSTLRRKGNIILIPERGSSPENTRNIFYKGTSPTRAYKE
The following text describes a protein:
Function:
Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC). Cleaves both linear MC and the tetrapeptide degradation product of MC. Cleaves the Adda-Glu peptide bond of linear MC heptapeptides.
Sequence:
MLDRRTLMGGILSMAGSKATGAALPGRRLRVFVATLGTETNSFSPLPTGLDAFRATMLWRPGEHPDFATEATGPLWAARERAREGRYEVIEGTCAFAMPGGPVSAQAYQLLRDEILDQLRRAMPVDIVAFGLHGAMLAFGEDECEADLLERARAIVGPDVALGAELDLHAHLSQRLVRAADVLVAFKYYPHIDYVERARDLLDLLERIRAGEIMPTSSLFNCQMVAGLATQSSPMKELVADLFEFERRGEVLSGSLIQGFRAGDVARMGSKVLIYTNNDQPAAASIAQDFGRRYQAMASIMKGNGPERSFAADIELAKAATAYPVILVDSSDNPGGGASGDNMALARAMLDNDLVPSCIGPIWDPLAVQLGFEAGLGADFSLRVGGKVGEASGLPLDVRGKITGLAENVTQNLQGSRPPLGRVVCISTAGLDIIVSEIRDQCYGPDMFRALGVEPANKRYVAVKSSEQWRIGFGDMGRSVIYVASSQQSSIRHYHKRSRPMWPFEPV
The following text describes a protein:
Function:
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L; [Isoform p46]: When prenylated at C-terminal, acts as a double-stranded RNA (dsRNA) sensor specifically targeted to membranous replicative organelles in SARS coronavirus-2/SARS-CoV-2 infected cells where it binds to dsRNA structures in the SARS-CoV-2 5'-UTR and initiates a potent block to SARS-CoV-2 replication. Recognizes short stretches of dsRNA and activates RNase L. The binding is remarkably specific, with two conserved stem loops in the SARS-CoV-2 5'- untranslated region (UTR) constituting the principal viral target. The same mechanism is necessary to initiate a block to cardiovirus EMCV; [Isoform p42]: Not prenylated at C-terminal, is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication.
Subcellular Localization:
Cytoplasm. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Secreted. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions; [Isoform p46]: Note=(Microbial infection) In SARS coronavirus-2/SARS-CoV-2 infected cells, prenylated form localizes to membranous perinuclear structures reminiscent of the endoplasmic reticulum rich in viral dsRNA which are SARS-CoV-2 replicative organelles; [Isoform p42]: Note=(Microbial infection) In SARS coronavirus-2/SARS-CoV-2 infected cells, since its not prenylated, is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication.
Sequence:
MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESNSADDETDDPRRYQKYGYIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL
The following text describes a protein:
Function:
Essential for spermiogenesis.
Sequence:
MAAAVTASMQPKSMTRAKKWDEVVENAYRFQLAGYRDEEEYRSVKKVDSAEKWDNGFVKKLQRKDGCFYYYNKARECSDKDVPKTKLYNY
The following text describes a protein:
Function:
Could be part of a sulfur-relay system.
Subcellular Localization:
Cytoplasm.
Sequence:
MKFAIALFDPPHSPAARRALRFSEAALAGGHEIVRLFFYQDGVHSASANVVSGQDEFDLPAAWRELVERNGLDAVVCIAAALRRGVLNAEEAERYGRPGANLGAPWELSGLGQLHEAAQSADRLVCFGGDR
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDSFDLKDEITEVIVDPDMYEDASGSDIESYQDDNQNGDDLSHKENQGEHSPPTHGRTLRKRQQYFCPECESCFKNNSELESHRKMHRVDHQYHCNICDKKFKHKSELMVHRREHSSKSEDVDYVVPTLSPQSSRNHDRSPEPKKSSCLPVGEKPHKCNFCEKRFNDKLILEAHQRIHIGKLMYPCTKCDESFSKAAVLAAHFNTHKDGKPFECDQCDRKFNDHSLLVAHKRTHTGEKPQKCNTCNKWFPNSASLAAHGECRSRPKPYQCRHCTKSFNDKALLITHEGVHTDTKPLKCTQCSESFYLKTQLVAHQAVHAPEKPFPCSQCDKSFNKEETLQAHIRVHNLQRIQAQPTYTY
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MTSALYLEHYLDGLEHLPNELKRNFTLMRDLDSRAQVLMKSIDEKADEYLKSLVNSKENISNEVKKEKLQGIQELFNKAKEYGDDKVQLAIQTYELVDKHIRRLDSDLARFEGEIQDKTVNAREKSEENVTKKGRKKVKDSKSTVKKKRTHSSEDEAKPAGNGGVANSGTSSGAANSNGKGKNTKKQKKGVENDDAAQDGGHSTPHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCPIEWFHFACVGLTTKPKGKWFCPKCSQDRKKK