lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds to and activates protein kinase PAK1. Plays a role in the regulation of cell morphology, cytoskeletal organization and focal adhesion assembly during cell migration. Also stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction, focal adhesion. Cell projection, podosome. Note=Localizes to podosomes in SRC-transformed cells.
Sequence:
MPPQQGDPAFPGRCEAPPVPPRRERGVRGPGAPGGRGRAGGPEGHGVKCVLVGDGAVGKTSLVVSYTTNGYPTEYIPTAFDNFSAVVSVDGRPVKLQLCDTAGQDEFDKLRPLCYTNADIFLLCFSVVGPSSFQNVSEKWVPEIRCHCPKAPIILVGTQSDLREDVKVLIELDKCKEKPVPEEAARLCAEEIKATSYIECSALTQKNLKEVFDAAIVAGIQYSDSQQQPKKSKSRTPDKMKTLSKSWWKKYCCFV
The following text describes a protein:
Function:
Component of the Clr4 methyltransferase complex (ClrC) which contributes to the establishment of heterochromatin by specifically methylating histone H3 to form H3K9me. ClrC preferentially ubiquitylates H3K14 and ClrC-mediated H3 ubiquitination promotes clr4 methyltransferase activity for the methylation of H3K9. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Has a role in both mitotic and meiotic chromosome segregation.
Subcellular Localization:
Cytoplasm. Mitochondrion. Nucleus. Chromosome.
Sequence:
MPPVRAEKKRKTDLIEQVCVTNKAGELVDLEDVLEYGPYSLTGILSSEKDEQEPLFDESIVLGYSIKISPVWTYNLKDVPEKETMSIWIVTPQRRYGILSPSSEYKAIYEQISEKNRLFYLIKTKFKDDMISGTLEDYDNYIEVLKEKLELPSCFQAILLVQKHIRFLLTQMVATSSLHVWSESPFFIRIRSSYEHLILQINKNIYNARQERKKSKLSSNNPSDNNTTMKSSLNQALTLINLPEQPFSISSPTATPQLGVVKRTSPLRFPLNDIWLSGLRIVDPNIESISLWKRIQVSTSPKHQRYISLQEVCSVIAQQLQITNLEALNKLSSHGETLLQIMHTAFTWRGTKLFNDIKHAIGFRSSVQQARSQFRGYCYDYLFMHCNNGEKTSLHLLRTLICMKLDFSNAQLAAKILFHFLLFDIGSGLSGSDYTYEQYINHSAVAFSFTEEIFEKNFVTVLPDFVKLFSISFGYWPAFSFYDELLKLLRNKYPKVYSSTPNLCDQVWLDRTNLFPCNRSTRSTLPYRPTKLLDLASASSCLSKKETDFKQDTGLYSYNLEKVEALKVSPDLQTGIWSCPVQNCLYFAVCDNPYKPSQVIYDHLLGHVDSKFIFKTPSNSVRSFTNKLEHIMYNIN
The following text describes a protein:
Function:
Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the pre-processed regulatory protein SpoIVFA and is necessary for the proper timing of sigma-K activation.
Subcellular Localization:
Forespore intermembrane space. Note=Is expressed in both the mother cell and forespore compartments but that synthesis in the forespore is both necessary and sufficient for the proper timing of pro-sigma-K processing.
Domain:
The PDZ domain functions as a gatekeeper to the protease tunnel and defines resting and active conformations of the protease.
Sequence:
MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQADSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQFSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDLNHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIAISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQIAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGKGTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPLKVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTAETLNQQIEKKKSDEKNDLQLQTALKSLFVN
The following text describes a protein:
Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
Domain:
PTB domain mediates receptor interaction.
Sequence:
MASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKKSERAASLSTVVPLPRSAYWQHITRQHSTGQLYHLQDVTSPLKLHRTETFPTYRSEH
The following text describes a protein:
Function:
Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds. May play a role in storage protein biogenesis.
Sequence:
MASQCAPPLPPRPRATAPFLLGHAPPHARPPRCAALTPSVLAATRPCFLASTRVLLRPQSEEAPASCSWSPSDPLLCASPASALLVAWRRRHSPAMGCKACDKPKPNYRKGLWSLEEDQKLRDYILLHGHGCWSALPMKAGTNVKIAAIPSSVVVLTSETFDSIVLDEFYAPWCGHCKHLAPIYEKLASVFKQDDSVVIANLDADKHTDLAKKYGVSSFPTLKFFPKGNKAGEDYDGGRDLDDFVKFINEKCGTSRDPKGHLTSEARLVPSLNPLVKEFLNAVDDKRKEVLSKIEEDVAKLSGSAAKHGNIYVTAAKKIMDKGSDYTKKETERLHRMLEKIPSSHSRSC
The following text describes a protein:
Function:
Regulates mitochondrial DNA recombination. Represses homologous recombination, preventing mitochondrial genome instability and unbalanced transmission of alternative mtDNA configurations. Binds preferentially single-stranded DNA. Does not bind to RNA.
Subcellular Localization:
Mitochondrion.
Domain:
The PDF region is required for protein-DNA interaction while the SSB domain is not required for ssDNA binding.
Sequence:
MNTFFKLGSLIQRTASQISSSFPKSRFFSDGESAVYHHARLFKKPLSTKLKFNLVNSVSLMGFVDRSIQVMNTGPDRFGVFTILRVKDPLNPNRSFRISLRMWDAMARTCIAHLKLNDHILVSGRLESYSKSSSDVYSGLNLDYQVKVAEVNYVAAPPSHVLDSQISKNPKTKTEDDIEESKKDEIYLWQVFFSNPYDWWDNRRNKKNPKQPDFKHKDTGEALWLCSDLPDWITRRLELFDQKNRFYDEEKTRRDRLSDYI
The following text describes a protein:
Function:
E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
Sequence:
MSDIIPVEVPTVGESISEVQIGNWLKQEGDWVKSGEDLVEIETEKASVQIPAPASGYLQSITKQSDEFAEVGQQIASIQVAEQPAGGDGGSSNGGSAPAAGNTASAPAPTASAPAPSSPAKSGGGFVMPAAQRLLDEHKLDASQVPATGPGGRLLKEDVLAYIRNGSSRPAPAAPPAAPAAPVAPTQQMSSPETASLMTSGGYRSEEVKPMSMLRRTIASRLVQAQQTAALLTTFNEINMAPVMAIRSKYKDAFAKKHGVKLGFMSFFAKATVEALRRYPAVNAEIRGDSMVYRNYQDIGIAIGGGKGLVVPVLRNVERMSFAEVEGSIAEYARLAGENRLQPSDLMGGTFTISNGGIYGSLLSTPIVNPPQSGILGLHSIQERPVAEDGQVVIRPMMYVALTYDHRIVDGREAVGFLVAIKETIEDPARLFLEV
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MSGSYQHLSNVGSRVMKRLGNRPKNFLPHSEKFIKKSTPEFMKSDLKEVDEKTSFKSEKEWKFIPGDRVVVMSGASKGNIAVIKSFDKRTNSFILDENGPTKTVPVPKQFWLEGQTSHMITIPVSILGKDLRLVADIDDEKTPGKTRTVAVRDVSFNGSYYDADYKKVMPYRCVKGQPDLIIPWPKPDPIDVQTNLATDPVIAREQTFWVDSVVRNPIPKKAIPSIRNPHSKYKRGTLTAKDIAKLVAPEMPLTEVRKSHLAEKKELAEREVPKLTEEDMEAIGARVFEFLEKQKRE
The following text describes a protein:
Function:
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Membrane; Single-pass type I membrane protein. Mitochondrion.
Sequence:
MYFSCFCALSSLWMSWSLIIIRSCDGAPLTQNEMSSSAQPLHCWETEEFTVLRTCFLCRDYQMKTEAQCTFSGFVEELKCNTSGLIEHRSCRSAAAEELKFWKFEGAMLTFSTLFAVLVMFRQRTLDRRAEYKVQQQIQGI
The following text describes a protein:
Function:
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
Subcellular Localization:
[Phosphatidylserine decarboxylase 1 alpha chain]: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain; [Phosphatidylserine decarboxylase 1 beta chain]: Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Sequence:
MRQKRDFHRFHRPHWRKLNLHSLVVVKVGVVTNLKLLHNRIHRIRQNRGRFPHWKRLSINVKPQGSWQAYLLSSLPLRSLSRIWGHFNNKEWPTFLRKPGFTLYAWLFGCNLTELKDPDLTHYRNFQDFFYRELRPEARPVDEDSFIVSPVDGRIVCQGRINNNRIQHVKGLSYSLEALLGGLSSCSPQVVDFDDSCMYPEKVAEHMKFATKHEIPNYRQTPRRVTVPSRRDGIERNRSAPALMCALTSSRLRLCPDCNRASMEEQEESDLAAGVKCSHISPAKNDAGDDDACSDSSSFYSLPASDNVPIPASVDEKKTSWIDTAEIASLDSLPWRNIRPGHQLFYSVIYLAPGDYHRFHSPADWVVESRRHFSGELFSVSPYLARRLHNLFVLNERVALIGRYKHGFMSMIPVGATNVGSIVINCDPTLSTNRMVLRKKSLGSFEEAVYSKASPVLHGQPFERGEQVGGFKLGSTVVLVFEAPEDYEFTTYQGQYVRVGESL
The following text describes a protein:
Function:
Does not appear to be required for cement gland formation.
Subcellular Localization:
Secreted.
Sequence:
MQAGLSLVCLVLLCSALGEAVLKKPKKQAGTTDTKTDQEPAPIKTKGLKTLDRGWGESIEWVQTYEEGLAKARENNKPLMVIHHLEDCPYSIALKKAFVADRMAQKLAQEDFIMLNLVHPVADENQSPDGHYVPRVIFIDPSLTVRSDLKGRYGNKMYAYDADDIPELITNMKKAKSFLKTEL
The following text describes a protein:
Function:
Required for ribosomal RNA processing.
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle.
Sequence:
MKVKTITRGTSLTRLNDQDPVKRNLDPSLHPFERAREYTRALNATKMDRMFAAPFLGQLGRGHQDGVYSLARDTKTLIDCASGSGDGAVKLWDASERCERWTSKAHEGIVRGLVFSNQGDVLSCASDRYVYMLNKQDGKVKRSYLGDSSLLDIDTSKGGDLFATSGENVSIWDYSRDTPVTKFEWGADTLPVVKFNYTETSVLASAGMDRSIVIYDLRTSSPLTKLITKLRTNSISWNPMEAFNFVAGSEDHNLYMYDMRNLKRALHVYKDHVSAVMSVDFSPTGQEFVSGSYDKTIRIYNVREGHSRDVYHTKRMQRVTAVKFSMDAQYIFSGSDDSNVRLWRARASSRASIRSTREENRLKYLDSLRERYKHIPEIRRIARHRHLPTNVKKAAEIKREEINSLKRREENIRRHSKKGAVPYEKERERHVVGIQK
The following text describes a protein:
Function:
Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Note=Located at the septum.
Domain:
Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity).
Sequence:
MQPMKSKKLYLALIIGVLLAFLTLSSWLGNSGLVGRFGVWFAALNKKYFGHLSFINLPYLAWVLFLLYKTKNPFTEIVLEKTLGHLLGILSLLFLQSSLLNQGEIGNSARLFLRPFIGDFGLYALITLMVVISYLILFKLPPKSVFYPYMNKTQNLLKEIYKQCLQAFSPNFSPKKEGFENTPSDIQKKETKNDKEKENRKENPINENHKTPNEEPFLAIPTPYNTTLNDSEPQEGLVQISSHPPTHYTIYPKRNRFDDLTNPTNPPLKEIKQETKEREPTPTKETLTPTTPKPIMPTLAPIIENDNKTENQKTPNHPKKEENPQENTQEEMIEGRIEEMIKENLKKEEKEVQNAPNFSPVTPTSAKKPVMVKELSENKEILDGLDYGEVQKPKDYELPTTQLLNAVCLKDTSLDENEIDQKIQDLLSKLRTFKIDGDIIRTYSGPIVTTFEFRPAPNVKVSRILGLSDDLAMTLCAESIRIQAPIKGKDVVGIEIPNSQSQIIYLREILESELFQKSSSPLTLALGKDIVGNPFITDLKKLPHLLIAGTTGSGKSVGVNAMILSLLYKNPPDQLKLVMIDPKMVEFSIYADIPHLLTPIITDPKKAIGALQSVAKEMERRYSLMSEYKVKTIDSYNEQAPSNGVEAFPYLIVVIDELADLMMTGGKEAEFPIARIAQMGRASGLHLIVATQRPSVDVVTGLIKTNLPSRVSFRVGTKIDSKVILDTDGAQSLLGRGDMLFTPPGANGLVRLHAPFATEDEIKKIVDFIKAQKEVQYDKDFLLEESRMPLDTPNYQGDDILERAKAVILEKKITSTSFLQRQLKIGYNQAATITDELEAQGFLSPRNAKGNREILQNF
The following text describes a protein:
Function:
Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2.
Sequence:
MQPLFNEAARPRPPVPLSVMGARPRGRLERGLAPTRRRAGGRGWTQRTGRPPGEEVRRAQGRAALGTPAASPSGEKAGSFASSGASRPRFRPVRFRAAAEGSAEAGGGEAGGGEAAVFAAAMLPAAPGGPGASRARSPCGPAPPDYDREHNLAVSRLVTLPLPEHMKDIVMLYEEEAAEWALYLREILLHVVEREAILLYLLENFSLRDLELLSLNSYKCKLLILSNSLLKNLTPKKCQFLEEVLRSPESVVTLLCGVKSADHLYQVLNIPGGRGEISTEQEPEDYISVIESVIFRGCKDYLEVDIPTDLRVEHSGKISERKEIEELSEASRNTIPLAVVLPAEIPCENPGEIFIILRDEVIGDTVEIEFTSSIKCVRTRPALWTKTVWYMKALDFPAGPVNVNVYCDGIMKATAEIKYYTTARAKECSLGVAGPGDGVCWSDMDELDDILTYIFKYEIPYYEFRSLQTGVCPPKEYTHFKELPTLLHCAAKFGLKNLAVHLLQCSGATWASKMKNLESSDPAHIAERHGHKELKKIFEDFSIQEVSTNNELENDYEEDFTSFSACSPPVQNPAFHHESSQTYRESAEGAESHETSKEKEENRSGTEATHSPAEDGSDSSESQYDDLYTFIPGDNPEIDAREPLVSDRPPLPPPRPVAAAFQLEKPHFTSQGKMLEGQTERSQHWCDPGARQETGGEPKREEEKKEEEKEPGEEEDPYTFTEIDDSDYDMILAHMSTKKKTGSRSFIINRPPAPTPRPTNLPPKEEATPYIAQVFQQKAARRQSDGDKSHGPKRQDRARVESQALSTARGCLPAGQEELILLQEQVKNGTLSVDEALEKFKQWQVGKTGLEMIQQEKLRQLRDCIIGNRPEEENVFDKLTIVHHPNGNESVHNENMSHSMPFGNKLPARLQVEKEFGFCCRKNH
The following text describes a protein:
Function:
Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules. Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MAELQGSEIPGDPALCSGRFTISTLLGGEDGGRAHYGQPDAPPAAYDTAHSSTFYMRTFGYNTIDVVPTYEHYANSAMPGEVKKVRPTLADLHSFLKEGSHLHSLAFETRSGHELSDGLVEDASSAAGEKPSGEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWVIILLSVTVTTITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVAVAMHTVGFAETVRDLLQEYGSPIVDPTNDIRIIGVVTVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYFVGTLIPPSQEKASKGFFSYRGDIFAQNLVPDWRGVDGSFFGMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTFSYLAISATIGSCVVRDASGGLNDTVVPGSSDCEGLACGYGWNFTECSQKRNCHYGLINYYQSMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNNEPVRGYLLSYVIAVAFILIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFHYYNKWVALFGAVISVVIMFLLTWWAALIAIAVVIFLLLYVLYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEEHIKNYRSLWALNPFLLAVLLSFFFSPLCLLGRPELVWSSLTQQSLILCVWLSLALPWQGPRKQRMPELRLISSGHTKWLNKRKIKAFYSDVIAEDLRSGVQILIQLPPFPCLPPINIGQDCVYFLPSDAFDFNYGVCVMRMREGLNISEVMQAHINPVFDPTEDQKEARANGSRPSVSVNPEVLVAEEQASTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKKRWNKCKIRVFVGGQINRMDEERKAIISLLSKFRLGFHEVHVLPDINQKPRPEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEINRNKMKSLRQVRLNEVLLDFSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILTRGNQENVLTFYCQ
The following text describes a protein:
Function:
Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.
Subcellular Localization:
Secreted.
Sequence:
MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHTFNLKMFLENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISITATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR
The following text describes a protein:
Function:
Aspartyl protease. Not able to cleave BAG6.
Sequence:
MVGRRKALLFSLCFFFLSLPSFSSLPSFQTLFPNSHSLPCASPVSFQPDSDSESLLESEFESGSDSESSSSITLNLDHIDALSSNKTPDELFSSRLQRDSRRVKSIATLAAQIPGRNVTHAPRPGGFSSSVVSGLSQGSGEYFTRLGVGTPARYVYMVLDTGSDIVWLQCAPCRRCYSQSDPIFDPRKSKTYATIPCSSPHCRRLDSAGCNTRRKTCLYQVSYGDGSFTVGDFSTETLTFRRNRVKGVALGCGHDNEGLFVGAAGLLGLGKGKLSFPGQTGHRFNQKFSYCLVDRSASSKPSSVVFGNAAVSRIARFTPLLSNPKLDTFYYVGLLGISVGGTRVPGVTASLFKLDQIGNGGVIIDSGTSVTRLIRPAYIAMRDAFRVGAKTLKRAPDFSLFDTCFDLSNMNEVKVPTVVLHFRGADVSLPATNYLIPVDTNGKFCFAFAGTMGGLSIIGNIQQQGFRVVYDLASSRVGFAPGGCA
The following text describes a protein:
Function:
Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein.
Sequence:
MFLRPEPELGWLPTHVQVTILQARGLRAKGKHGTSDAYTLIQIGREKYSTSVVEKSPGSPEWKEECSFELAPGALERAENCELQLTVMHRALIGMDQFLGQVTIPLQHVYQEGRSQRNQWYKLRSKPGKKEKERGEIQVSIQFTRNNLTASMFDLSIKDKPKTPFGKLKDKMKVKKLFDMESSSAIVPSSVGRLDSDDEDEKKPKSKAALFLKGRLRKNSLTRSNTSLGSDSTISSTSGTVANNAGISIVLPDPGKKPASRNSSLSVEPSAQSSEASPRMTHKRAFSDEVSQLSIFPEPKVVQNLKPKGSPISKSSVCINGSHVYTETPLPKPLPSPLEKLPPVSRSFQNISKKAEESSIPGAATGQLHSLDKQEKKPIASPTPAQEEVKVPAKSKNDEIHKESKPVQITSPMVFSEEPPKVKAQDGAGKEEKKPKANLFHHDSGTKIHVEPAHQTSVASEEKAKPGSWFGSKDPKETPQKPSFPSGSIATSEAAERGSSLVEEHSPLAFSPAPEVHKKPLHQEKSASRNNLAEPHEVSLASRNPYRSPVNTAELEEEFDAFASSRLQPAIENPTPTEANRKSHLDNDGDLSCPGHYIQSINIQISNAAQKSDRTVGVLPRLLTSTRPEVKAITKDELFPASLQSSDHKLHISPAESARIQPKEEQCSLTSDQGKAWSLPDKWKTGDGNWWHSNEHSAAKEVSDMYRGYNPELNQYKPLPESISSRLPSESDKDGYSQIHETEHKIATVSPLILEEHAITRFTDLHKTPLPNPVPQSKSRHSLSIIPEDETTDQVGHHSSTSFAGDLHISTEFKEGATYTDHNSNSVFTVSGQETLPISGSGESKEFIEPETKLLDISTDLESARPSKPPQQVLPQEKTNDENHKQLQNKDNDVSRTSLKLSENETVPNHIVPPVSFYPVIEIKSPMQSPAIQDEKAISEGHCMSAREDDRQKLGVSTGDSTVPEQFQTCPSKVSLDTLDISDMGESPNKLDVINPTSSNDLTSAHQSKPFISHGSTTQENNDFHFRKPISVSLSKSQRNVVCEPETNSTRRTDQSSLLFLSAVEEQLPNNTFDLPKIKPEALVASPAPVTPQPEGSLHAKAGLTEGLQIYEAGLDSPLKNKFVDCKYETGAKELNNDLQSDLLLSEQSTWSGDVIVDFKNEDFWRSEADLKEGLDTKSVPSPGNPFTPTDKTPVLSNKNPFADCSLSHSSEASLPENASFKDLHAQMALNDSSRSTVPANMKPSFLHGGPPLAFSTPSFVAVPNPKLSNFPSPIMPSATSAVNTTTTTNTQSPALSSASSGVKASGLSVLPQETQPAENPFMPVKTSPHPVKPISATLSDSEKKTHKPGLTTALSSGLEMLKSVTSGQHTAPKKQEVDRLKDFSSPDLAAKYYHLTHDELISLLLQREAELGRKQNHVQELENYIDQLLVRIMDQAPTLLQVPLECKKDHK
The following text describes a protein:
Function:
Binds hemin and thiamine.
Miscellaneous:
MISCELLANEOUS: On the 2D-gel the determined pI of this protein is: 5.7, its MW is: 26 kDa.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
TLTGYIANFSVLNXEAYLFINDKYVLLDYAPGTXNDK
The following text describes a protein:
Function:
Odorant receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKQYSVGNQHSNYRSLLFPFLCSQMTQLTASGNQTMVTEFLFSMFPHAHRGGLLFFIPLLLIYGFILTGNLIMFIVIQVGMALHTPLYFFISVLSFLEICYTTTTIPKMLSCLISEQKSISVAGCLLQMYFFHSLGITESCVLTAMAIDRYIAICNPLRYPTIMIPKLCIQLTVGSCFCGFLLVLPEIAWISTLPFCGSNQIHQIFCDFTPVLSLACTDTFLVVIVDAIHAAEIVASFLVIALSYIRIIIVILGMHSAEGHHKAFSTCAAHLAVFLLFFGSVAVMYLRFSATYSVFWDTAIAVTFVILAPFFNPIIYSLKNKDMKEAIGRLFHYQKRAGWAGK
The following text describes a protein:
Function:
Required for homeostasis of heavy metal ions such as cadmium, cobalt and copper.
Subcellular Localization:
Endoplasmic reticulum. Vacuole. Membrane; Multi-pass membrane protein.
Sequence:
MSTNSNQNSIHTPIPEFPENRSTNRSELAAAFEPPDDDVEYSETAPLYSSARASIEGEEAFYQHLSTPDPGNDSGHVRSSNDRIPSTSSNHADGHHVDSVFSNLSAKPTVESNTEELEEEPPSYEQAAADTAPPYWDTTMVIPDYGSNEIYIDGMSVGTGFSFVWSACVAILFPFVGFLVTYVLSTTHLGRYGAQIGLSLTLFQRGYIMISESGMENNDDQYNYDELPHQKLIGSILIIIGWCLVLVDTFGFIRIRRMKNAISRTDSPGETSPEEVV
The following text describes a protein:
Function:
FMRFamide-like neuropeptides. Ligand to G-protein coupled receptor npr-1. Involved in modulating locomotion quiescence during the sleep-like state called lethargus which occurs during molting between larval and adult stages, acting via npr-1. Together with flp-1, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit. Plays a role in the navigational capacity of sperm and the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites; SVPGVLRF-amide: Excites muscle tension; [EMPGVLRF-amide]: Activates the G-protein coupled receptor npr-1 more effectively than other flp-18 peptides. Inhibits the activity of dissected pharyngeal myogenic muscle system.
Subcellular Localization:
Secreted.
Sequence:
MQRWSGVLLISLCCLLRGALAYTEPIYEIVEEDIPAEDIEVTRTNEKQDGRVFSKRDFDGAMPGVLRFGKRGGVWEKRESSVQKKEMPGVLRFGKRAYFDEKKSVPGVLRFGKRSYFDEKKSVPGVLRFGKRDVPMDKREIPGVLRFGKRDYMADSFDKRSEVPGVLRFGKRDVPGVLRFGKRSDLEEHYAGVLLKKSVPGVLRFGRK
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MARAGGHGMGNPVNVGIAVQADWENREFISNISLNVRRLFDFLLRFEATTKSKLASLNEKLDILERKLEVLEVQVSSATTNPSVFN
The following text describes a protein:
Function:
Most likely a component of the atg-5-atg-12-atg-16.1/atg-16.2 complex, which is recruited to the preautophagosomal membrane and associates with lgg-2 to promote autophagosome formation. Plays a role in the recruitment of lipidated lgg-1 probably to the autophagosome membrane to promote autophagosome formation. Furthermore, association with atg-5 is required for the nucleation of lgg-1 positive autophagosomes. Although its role in autophagosome formation may be distinct to the role of atg-16.2, it functions in a partially redundant manner with atg-16.1 to regulate autophagic processes. In a daf-18/PTEN- and daf-16/FOXO-dependent manner, required for maintaining the numbers of germ stem cell progenitors in the gonad during the late phases of larval development.
Subcellular Localization:
Cytoplasm. Cell membrane.
Sequence:
MTDNRTSFRLEILNRLCKRERQQRCVKDMFKNYSLLDEQLQQSHRSRSVSVNDEHFKGNVNDRLAVMKEEMANVYRMKSKNDQDLIDANRKLADSESRYSLVSSQRDKLRIETDAIVKKMTVLENELAELKEENSVINTERVSLVATCNYLTEKKTQLDNERFQLLNRIRELQEKSAEFMNAEIALQEERAQMRIREQIAKATADLNLGDERASSAFGTSPETLDEFMMTDVLPSEVKFKLSTHDGEVHDVEWMSDDTFATAGSDSKVQIWRVSPNKTDASKVSTLSGCLGPVNRLDYDSQRHVCLASSNDKTCRLWNIDSQRLLSTFSGHTDKVSSARLFQSHNVISGSADRTIKNWDISSIRCLKSYLVGSTVFDIVAKCGVSQSSFISSHFDKKVRFWDARSSDATYSVELGQKVSSLDISMDGLQVLASSRDDTLSLIDVRNYGIIHLYSAEQYKTSCDSTRAIFSSTGEYVLAGSSNSSVFIWNTKTTKLEKVVKTARSDSAQIMSLAWNPSGRGLLACDRQKTCTLWR
The following text describes a protein:
Function:
Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA.
Subcellular Localization:
Chromosome. Nucleus, nucleolus.
Sequence:
MLEELGLIPTIGEDDEVAVEPESDSGEEEEEGPIVLGRKQKALQKNRSADFNPDFVFTEKEGMHDGSWAMADVMSQLKKKRAATTLDEKIEKVRKKRKTEDKEAKSGKSEMEKEAKEGSEPEEQEDLEGEDEAGSEDDDSETDYSSADENILTKADTLKVKEQKKKKKKGQEAGGFFEDASQYDESLSFQDMNLSRPLLKAITAMGFKQPTPIQKACIPVGLLGKDICACAATGTGKTAAFALPVLERLIYKPRQAPVTRVLVLVPTRELGIQVHSVTKQLAQFCSITTCLAVGGLDVKSQEAALRAAPDILIATPGRLIDHLHNCPSFHLSSIEVLILDEADRMLDEYFEEQMKEIIRMCSHHRQTMLFSATMTDEVKDLASVSLKNPVRIFVNSNTDVAPFLRQEFIRIRPNREGDREAIVAALLTRTFTDHVMLFTQTKKQAHRMHILLGLMGLQVGELHGNLSQTQRLEALRRFKDEQIDILVATDVAARGLDIEGVKTVINFTMPNTIKHYVHRVGRTARAGRAGRSVSLVGEEERKMLKEIVKTAKAPVKARILPQDVILKFRDKIEKMEKDVYAVLQLEAEEKEMQQSEAQINTAKRLLEKGKEGPNHEPERSWFQTKEERKKEKIAKALQEFDLALRGKKKRKKFVKDAKKKGEMTAEERSQFEILKAQMFAERLAKRNRRAKRARAMPEEEPSRGPAKKQKQVKRSVFDEELTNTSKKALKQYRAGPSFEERKQLGLPRERRGGNFKSKSRSCWSNTLGERTDTKTQPLQHHGMLPTLEANPFAILRKEKLSAMRILVPV