lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin).
Subcellular Localization:
Cell outer membrane; Peripheral membrane protein.
Sequence:
MMTHAVLTARIAKISLTCSILSWSLLIVGCATDRLDLAPASYTEPWTPDGNARASMGGGNFSVPPNPIVAELAQPPTIKSDHAYSLPELIDIAQRQNPDTRIAWQQARQAALAVGMGEAIFLPIISASVIGGYQRTTTPLPYAIGNEKDLKTTGSAVIPALALQWLIFDFGQRSALLDAAKQTSYAANVTFNGMHQKLIYDVTRTYFQYGAAQAQSQIAKQTLQNSLKIQDAAEERQKKGIATTVEVALARQQVAQSQLRRVVAKGTERDAYQALLGAMGVSPSLDIKAAYTEDRALPDGISAPTEKMIQLALSQRPDVLASYAAVEAAKAGIKATEADFLPKVYLAGAVAGGDGHFDIQGLPGISPQTSSSSILVGVSVPLYDGGIRAARVKEAESRAAVAAEGFKKTQELAVREIVVAADTLRSALESNQAALNLVKTSFISYDAALESYRSGVGTITVANEAANGLLNAQQMSTDAHAASLVAAANLAFVMGKMTNTSPPLELLH
The following text describes a protein:
Function:
Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. Binds GPI-anchor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGLLTNPSISQKAKYCRKLVRYNTAICLTLYLLGVGFFCALPDANFNSGTYFSENALLPGLVNSELEMETVNLVKSLSSELQRERENYPKGMPYPWLLAKMRRFGLETHTHNFTLNYPFGGGKRFKGENVYGILRAPRIASTEAIVISVPYRPPETVHTDVSAGVPLMLAFADFARRKKYWAKDIIFLVTEQEQLGMQAWLEAYHGGDEGRILDSGLLRARAGSIQAALNLEVQSLDISHINLKIEGLNGQLPNLDLHNLVQKLSSKNGIIAGYKQSSSSPKRSFRYQDKLLNLLSMVFSQASGVPTGNHGLFHKYGIEALTLEAVKRERTQQQQFQEVGSMLRIIEGICRSLNNLLERFHQSFFFYLLVSNDRFVSIGDYMPSLALMAGALLIKAFIHYLSLYYTGDNDETEKSEETDAVETKQKAGNIDIGYFSVGIVLLVAHTLGALVVLLPQSKAVSNYLHEAELSTQFGLFSLFVAVLVVALTLPAFCSLSGINGEALHVAVLLELGTVLLAVGMLNFSLGFSLSVLLVPFIILIRPAASRGAMFLSRLCCLLINPLVVLYCVLLALTWYLFPELAFKPMLNKALTATMDALTFSVVDSMIYGNWLFDMVSLIFVPCWVLLWVLLFPK
The following text describes a protein:
Function:
Involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella.
Subcellular Localization:
Golgi apparatus, cis-Golgi network. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm.
Sequence:
MAKDPLAEAGLHFDELNKLRVLEPDVSQKTTELKEECEEFVDKIGQFQKIVGGLIELVDELAKEAETEKMKAIGARNLLKSVEKQREAQHQQLQALIAEKKMQLERYRIEYEALQKVEAEQSEFIDQFILQK
The following text describes a protein:
Function:
Cysteine protease inhibitor. Inhibits cysteine proteases CP1, CP2 and to a lesser extent CP5.
Subcellular Localization:
Cytoplasmic vesicle. Lysosome. Cytoplasmic vesicle, phagosome. Note=Upon host erythrocyte engulfment, localizes to phagosomes.
Domain:
The BC, DE and FG loops form a tripartite wedge that blocks the substrate-binding site of target cysteine proteases. The BC loop interacts with the catalytically active cysteine and histidine residues of the protease catalytic center (Probable).
Sequence:
MKQFIFFALLCTSTYAAIHILTEKEDHATLHISFNDLIKIQLRTNPSTGYAWNIEYPTDTFSLSQDTIKAEPHPSGMVGFPSIREIQLKPLKVGTTTIKLGYSRPWEKGKEPLRSLTYSVVIR
The following text describes a protein:
Function:
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways. Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK. Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAVDGCGVVCKYILVLFNIIFSVVGLAFLALGLWLRFSDGTRGIFNVEALNSSAFVLGVTVLIVLGSVMLVVVVFGDYGACSEKRCALQTFIVLLFFLAVAEVVVGVLAYTSRDEVGRRLGEFYVSLYTLYANNNDPALAITLTFIHNTLHCCGVTGISLVEIVKKTCPKPDGFMESLVMANCPTTILNVFDRRASLVLGVFLGTGALLFVALICSVTLNAKIRQSASPPQYIILTQSTAALTVSQPPQQDFGSPPHPYQDPVVFTPLSAANIPIQA
The following text describes a protein:
Function:
May be involved in the transport of nicotianamine-chelated metals.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEPVNDFQEGISTEHAFEAEPVPSLSETITPRSMVVSFILSVTLSIVAMKVTLSSGFIPSFSIPAGLLGFCVSRASIRILDYFAVAQLPFTRQENTIIQTCVVACTSITFTGGFGTYILAMGKKAAVGDVNAQNNVEEPSFARMITFLFLISFAGMFIIMPFRKVMIIRHRLTFPSGTATAHLINSFHTPQGVKQARKQVTLLFKSFGGTIAWSLFQWFFASGPGCGFKFFPTFGLEAYKHGFFFDFTMANVGIGMMCPYMIVFSVFIGTIISCGVIWPYIESKEGIWYPSNLGPNSLNGIRGYKVFIGLSMIMADCLFVFLCIMVRTTCAMIKRRRQAMQGGGGNAQPFQGIDIADQPVKSFDDRRRAQVFLRDEIPDSVTIGCYVLLSIISIAAIPHLYPQMRYSHVALIYLAAPVFAFCNAYGFGVTDMNLASTYCKIAMFAFGSWVGIKSGGVVAALVAGGITMSILGNAADVAQDLKTGYLTLTSPRAVFISEAIGTALGCVVNPTVFWVFYRVYKMGSGDMGDMPYAKLYRGFAMLSVGDGEQGLPRHSMLLFKVFFVLALALSVFREVASRKEWRIRRYIPSTIGMAITFFMPPRVPVGMCIGSLVAYLWEKMDAGRGRMLSPALASGLICGDGVGSILLSMLTLMGARAPICIKFLSRGDNVKLDAFLATLHDMR
The following text describes a protein:
Function:
Multifunctional protein that includes general (non sugar-specific) and sugar-specific components of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport.
Subcellular Localization:
Cytoplasm.
Domain:
The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain; In contrast to classical PTS systems, the fructose-like PTS has no requirement for HPr and Enzyme I; FryA combines a IIA domain with an Enzyme I and a HPr domains.
Sequence:
MLTIQFLCPLPNGLHARPAWELKEQCSQWQSEITFINHRQNAKADAKSSLALIGTGTLFNDSCSLNISGSDEEQARRVLEEYIQVRFIDSDSVQPTQAELTAHPLPRSLSRLNPDLLYGNVLASGVGVGTLTLLQSDSLDSYRAIPASAQDSTRLEHSLATLAEQLNQQLRERDGESKTILSAHLSLIQDDEFAGNIRRLMTEQHQGLGAAIISNMEQVCAKLSASASDYLRERVSDIRDISEQLLHITWPELKPRNKLVLEKPTILVAEDLTPSQFLSLDLKNLAGMILEKTGRTSHTLILARASAIPVLSGLPLDAIARYAGQPAVLDAQCGVLAINPNDAVSGYYQVAQTLADKRQKQQAQAAAQLAYSRDNKRIDIAANIGTALEAPGAFANGAEGVGLFRTEMLYMDRDSAPDEQEQFEAYQQVLLAAGDKPIIFRTMDIGGDKSIPYLNIPQEENPFLGYRAVRIYPEFAGLFRTQLRAILRAASFGNAQLMIPMVHSLDQILWVKGEIQKAIVELKRDGLRHAETITLGIMVEVPSVCYIIDHFCDEVDFFSIGSNDMTQYLYAVDRNNPRVSPLYNPITPSFLRMLQQIVTTAHQRGKWVGICGELGGESRYLPLLLGLGLDELSMSSPRIPAVKSQLRQLDSEACRELARQACECRSAQEIEALLTAFTPEEDVRPLLALENIFVDQDFSNKEQAIQFLCGNLGVNGRTEHPFELEEDVWQREEIVTTGVGFGVAIPHTKSQWIRHSSISIARLAKPIGWQSEMGEVELVIMLTLGANEGMNHVKVFSQLARKLVNKNFRQSLFAAQDAQSILTLLETELTF
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. bL36m may be involved in a process influencing telomere capping.
Subcellular Localization:
Mitochondrion.
Sequence:
MASLGRKFFAVGVLSRVFPSAFNAQKGLLKNASMFLTPAFRLSPSLLPWNFSRGFKVKASVKKRCSSCYFVRRKGRLYVLCKKHPRHKTRQG
The following text describes a protein:
Function:
Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional activator that induces the transcription of alpha-specific mating genes.
Miscellaneous:
MISCELLANEOUS: The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA). MTLALPHA1 is not represented in the genomic sequence of strain SC5314 because that haploid assembly includes the mating type a allele of this locus; MISCELLANEOUS: Most C.albicans strains are heterozygous at the MTL locus and do not readily undergo white-opaque switching and mating, but mating occurs in hemi- or homozygous strains. Mating takes place in opaque cells, produces tetraploid progeny and seems to occur rarely, if at all, in nature. Conservation of mating capacity is rather thought to be due to the simultaneously regulated white-opaque switch, which seems to play an important role in host commensalism.
Subcellular Localization:
Nucleus.
Sequence:
MGNKKKTRKTVPKEFISLFRVHSGRDAPRRDTREVQKSKKHGFRFTSLPDLPVASNALQELLLEYGLLNDIKWDSKGLKASKNKKTKLKPINSFIAFRSFYSRTISNPEHQRELSSKLADVWTQESNQEVWKQYTQSYNNYLLLPDAKLNFVDWLCEALDYTIDNTTPQIEDISLTSYNQLLSGTIEDVYIMK
The following text describes a protein:
Function:
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
Subcellular Localization:
Nucleus. Mitochondrion.
Sequence:
MCIEAMRTSRASRETAKVLQALSPPARRQTRSTSHSALLKGFAYNAGKTEADPDDGEDDGSSLTSVDTVDIEDILEPSAKRRKTKASSAAKTTSNSTRRTPEKKVEKLVKKENSQPKARRVPARKVKNEDGSFTVEAPSNWDAIYSIVKKMREDNPTAPVDTMGCAELYWRASSPRDRRFQTLIALMLSSQTKDTVTAVAMQRLHTELGEGGAPAIKLETEHAESIVKQEAENGEPAIKQEAKDGVPPANPSHDSTLNLENILAVSPERLNSLIGTVGFHNNKTKYIKKAAEIIRDQYNSDIPSTPAELMKLPGVGPKMAYLCMSAAWGKHEGIGVDVHVHRITNLWGWHKTKTPEETRMSLESWLPKDKWHEINKLLVGLGQTVCLPVGRRCGDCGLAGTKLCKSEIKGMAPKNNGRGLPKKEIVVETFSLTGEPKIKVEGE
The following text describes a protein:
Function:
Initiates the restart of stalled replication forks, which reloads the replicative helicase on sites other than the origin of replication. Recognizes and binds to abandoned replication forks and remodels them to uncover a helicase loading site. Promotes assembly of the primosome at these replication forks.
Sequence:
MSSENGPEQGGAQDAPPEQLALIRETVRRTAAPRAKPRTWRGAALAKELPVARVLVDKGVLHLDRYFDYAVPEELDAEAQPGVRVRVRFGAGRHRVRDGRREGGGLIDGYLIERLAESDYAGPLAALAQVVSPERILDEELLGLVRAVADRYAGSVADVLQLAVPPRNARAEKRASPQPLPAPPVPEPGSWARYEQGAAFVAALASGGAPRAVWNALPGPQWTDELARAVAATLASGRGALVVLPDGRAVARADAALTALLGEGRHAVLTADAGPEKRYAQWLAVRRGAVRAVIGTRAAMFAPVRDLGLVALWDDGDDSHSEPHAPQPHAREVLLLRAAQDRCAFLLGGWSCTVEAAQLVETGWARPLIAAREQVRAAVPLVRTVGDQDLARDEAARAARLPTLAWQAVRDGLRHGPVLVQVPRRGYVPRMACAACRTPARCRHCSGPLEGQESGSALRCGWCGREESAWHCPECGAFRLRAQVVGARRTAEELGRAFPAVPVRTSGREHVLDTVSETPALVVSTPGAEPVAEGGYAAALLLDGWAMLGRPDLRAGEDALRRWLAAAALVRPQSAGGTVVAVAEPTLRPVQALVRWDPVGHALRELAERAELGFPPVSRMAAVAGPPDAVTGFLDAVELPREAEVLGPVPLPVTPAGRPRRVGAPPPGEHWERALVRVPPGRGAALAGALKAAQAARTARGSDTAVWVRIDPPDIG
The following text describes a protein:
Function:
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular Localization:
Mitochondrion intermembrane space.
Sequence:
MSRAGADKDFSKAPQGDPQRGEEIYKQTCAKCHAINPNATGPDSHGPKAPNLWGLFGRRSGRLPDFPRGYSQALQLKGTIWNEETLYVWLENPQKYVQGTKMDFEGLPEPKDRADVIEYLKKATGPPVRTNERGEAAGRYGNHG
The following text describes a protein:
Function:
Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport. May play a role in the processing of autolysosomes.
Subcellular Localization:
Cell membrane. Golgi apparatus membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Sequence:
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGCIGLMIILIESFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITVIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVMSQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKASLMSTMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPVKLVPDLYFLKPGDKPHKYKTSLLLQNSTDSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIVSNYYLYHLNVTETIQIWSTPFFQEITDIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPNNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIVNILVGDIEPTSGQVFLGDYSSETSEDDNSLKCMGYCPQINPLWPDTTLQEHFEIFGAIKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEEDNSCGTLNSTLWWERTQEDRVVF
The following text describes a protein:
Function:
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MGSRCAKLSTGHGPAQNTGHSRGHESSMKKLVACVSQDNFSLSSEGEEEEEDEEEEEEEEEEEEEEQIPVKGKLLLLEPEKQESAEDGEAQPSPEPKQTHS
The following text describes a protein:
Function:
Exo-inulinase involved in utilization of the plant storage polymer inulin, consisting of fructooligosaccharides with a degree of polymerization (DP) value from 2 to 60. Splits off terminal fructose units successively from the non-reducing end of the inulin molecule, and also hydrolyze sucrose and raffinose (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MARLLKAVTVCALAGIAHAFNYDQPYRGQYHFSPQKNWMNDPNGLLYHNGTYHLFFQYNPGGIEWGNISWGHATSEDLTHWEEQPVALLARGYGSDVTEMYFSGSAVADVNNTSGFGKDGKTPLVAMYTSYYPVAQTLPSGQTVQEDQQSQSIAYSLDDGLTWTTYDAANPVIPNPPQPYQAQYQNFRDPFVFWHDESQKWVVVTSIAELHKLAIYTSDNLKDWKLVSEFGPYNAQGGVWECPGLFKLPLDGGSSTKWVITSGLNPGGPPGTVGSGTQYFVGEFDGTTFTPDADTVYPGNSTANWMDWGPDFYAAAGYNGLSIKDHVHIGWMNNWQYGANIPTYPWRSAMAIPRHLALKTINNKTTLVQQPQEAWSSISSKHPLYSRTYSTFSEGSTNASTTGETFRVDLSFSATSKASTFAIALRASANFTEQTLAGYDFAKQQIFLDRTKSGDVSFDNTFASVYHGPLVPDSTSMVRLSIFVDRSSVEVFGGQGETSLTAQIFPSNDAVHARLVSTGGATEDVRVDVHNITSTWN
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MFDVFGSVKGLLKLDQVCIDNNIFRLHYKATVIILIAFSLLVTSRQYIGDPIDCIVDEIPLNVMDTYCWIYSTFTIPNRLTGIAGKDIVQPGVASHVDGHDEVKYHKYYQWVCFVLFFQAMLFYVPRYLWKTWEGGRIKMLVLDLNMPIMNEEAKERKKILVDYFADNIKGHNFYAMRFFFCEVLNFVNVLGQIYFMDFFLDGEFSTYGSDVVRFTEMEPEERGDPMARVFPKVTKCTFHKYGPSGSVQKFDGLCVLPLNIVNEKIYVFLWFWFILLTILTGISLMYRFAVIMLPRLRLLMLRARSRLSAHDEVELIASRCQMGDWFILYQLGKNIDPLIYKEIICDLAQKVEGKEIV
The following text describes a protein:
Function:
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHAASIGEGRPPTKARDSQMPGRDPSPFRHVHSVPMPRRPHLPPPAVSALLGVALALTMPPLKTGLLAPFVLAALLWYAAQAPAPRQVAGRVWWAVFALTTIHLWWLTAFLGNIFSFPPAGVLAFALYALEGGFFALMAYVVARLVHSPRGRVWALAGGWGVVEYLRFLGPLAFPWPTLGYALLPTPLIQVADLGGVLLASVLILGLAAALASRSKKGVLTVSLVWLAALGYGLTRTPGEGPEQPMRVLRTTFDSFGRATGYVSPEQQFSQMLPVSQSRPPGSVLVWSETALMLPAPPSTVPQFPAPGITGLRTLTPDQNSVISVNTDGQVTGQNVKAKLVPFGEEFPFYRILKPVYGLFEKALGFEFGSLEAARTVQPLSLNGVKYGTYVCYDSVFPWVARQLARQGAGLLVNPSNDGWYQGWGVQQHFWMGRVRAIEQRRWLVRSVNLGVAGAVDDLGRPVQTVDRGDAVQSLDVRPKLLGRQTLYARLGDTPALALLLALVGVGVWRRREGIHS
The following text describes a protein:
Function:
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
Subcellular Localization:
Cytoplasm.
Sequence:
MGEAVAGTVGERFRELYGAEPEGVWAAPGRVNLIGEHTDYNDGFVMPFALPHQAVAAVSRRDDGILRLHSADIDADPVELRVADLAPGSDKSWTAYPSGVLWALREAGHELTGADVHLASTVPSGAGLSSSAALEVVLALAMNDLYALGLRGWQLARLCQRAENVYVGAPVGIMDQTASACCEAGHALFLDTRDLSQRQIPFDLAAEGMRLLVVDTRVKHSHSEGEYGKRRAGCEKGAALLGVDALRDVPYADLDAALERLGDEEEVRRLVRHVVTEDERVERVVALLESGDTRAIGAVLVEGHASLRDDFRISCPELDLVVDTALASGALGARMTGGGFGGSAIVLVEAAGVDAVTKAVEDAFAAAGLKAPRVFEAVPSAGARRLV
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MLMVFSEITGTLAFLQPQPDDDISDRLHYYYTTTFLLLTAVLVSLKMFGGRPIECWLPAEYKKSWEDYTGQFVEQRGQTMVSYYQWVPFFFVLVAVMFYAPCLIWRLMYDKSGIRLKDIMSFANDKSNVQPAARRANIHGLAAHLSSIFKHRFTFGGAKKKNTFFRLLNLRFYEAFLTYLYIFIKFLFLVNVVLQMFLLNKFLQTDAYGIYGYGIRILGNVQRHTVQCVLVINIFTEKIFIMLWIWYTLLAVISFGAIVSWIFQSIPFEQRKKFIIRRLELADVDFKRHSYEAELDEFVRDFIKMDGIFVLRMITIHSGVLVCTEVVDLMWDQYLAEIGERDAKFIGQILSYELDPESNGKLDEGPLRPNSAAGLSFDLGKDNASTNLALLARRKTSVLVPLVSREDLTNLSDTPHYNHHLRPPSSRGGAISIVFYGILPSHIDCCYSILRTRRVTVGAASKLSKIRVVRKNIARVLTVINQTGIIYKKTRAMRRALAKHDASIKPVKPRGISAWNDVRSSDGKSETNFEQDGSDRKRIRTTMGTRHYRETKLLPTLIFIKSVVWKNLFNKEADKLERSNDDNKTYQALHLRRRRQAVPRPHRRSPPLSATPLDKKMELMRWIKALNRERNERRKSVKMKKKRRRNGEKKMRMIEKWRKEKKRGKKRKEMRRKRKANGWIGSSREPRVPFLDSRLTMAAPPPPMPKEVEITPDAVTFACGNAGKSTYFDIKIVNKGTKRAAFKVRCTSANVFRVQPPTGFVKGGGESLVVRLWFQNRRFIESTKHYFAVHIIFNDDAKMPNDVFPKTAKPDGVKRLSVAFTKDAPATSAGPEPAAPASLMAAPSIMPSAMGAPAASAIGAPPAPPAAAGAPAVPANRCYLQHTGKNPGRRQEATNALLGQ
The following text describes a protein:
Function:
Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). Adds the first alpha-1,6-mannose to the Man(8)GlcNAc(2) and Man(9)GlcNAc(2), but not Man(5)GlcNAc(2), endoplasmic reticulum intermediates (By similarity). Represents the first enzymatic event required for synthesis of outer chain mannose linkages on yeast secretory proteins. N-glycan outer chain epitopes play a crucial role in the host-fungal interaction, virulence, and host immune response such as interleukin synthesis or phagocytosis by neutrophils.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=Is recycled between the trans-Golgi network and a late compartment of the endoplasmic reticulum.
Domain:
The conserved DXD motif is involved in enzyme activity.
Sequence:
MLQLREPQMVHKHLKLAVLGIVVIFTTYFIISSLSSPTSTHKTEYNSPKLQLAKELELNSNWKELGLNFQPNKKYSLPDESTLRQQLSYQFPYDESKPFPKNIWQTWKVGIDEKSFPKRYLKYQQTWEDKNPDYKHYVVPDKQCDLLIEQLYSQVPDVAKAYRIMPKSILKADFFRYLILFARGGVYTDIDTVGLKPVDEWISNSEMILEKKNRSGLVVGIEADPDRPDWADWYARRIQFCQWTIQSKRGHPMLRELIAKITDITLTRHKKGQLKKVLGKNEGGDIMNWTGPGIFTDTVFEYMNNILQSPEVFKNKKKWATIIDWKLFTGMEQPIAIDDVLVLPITSFSPDVNQMGAKDSHDPMAYAKHMFSGSWKDDGMPEMEQ
The following text describes a protein:
Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKYRCGKCWKELDDDQLKTLPGVRCPYCGYRIIYMVRKPTVKIVKAI
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MRVALKLAYIGTEFHGSQIQPNVETVEKELFKALRNLSIIESPKSADYTCAGRTDAGVHALGQVVAFDTEKPNLAIPRVINSELPPAIWAWAHAEVPYYFDARRSAVSRHYHYVMSGEDYDISKMREASKLLLGTHDFENFSRSNGEKSTVRTLERINVRVDGEITKIDVVGNSFLWNMVRKIVTALSMIGNGVRDNDWLLQMLNPEIYEEGIEPAPPYGLTLMGVNYGENIEWIEDDYSIRRAGEQNHKRILRHRVMAEVLEELISHE
The following text describes a protein:
Function:
Delivers copper to copper zinc superoxide dismutases.
Subcellular Localization:
Cytoplasm.
Sequence:
MDDKNLEIKVELNVDISCQSCVDSISKELREKLENTKLVEHDIPEQRIVLQGTDLTQDILETIKNTGRNATICGLSSTTTTTSTSPSSSTCHKKQETVSGSAVCSLGLIENWQKGCGGSGGVGSKGVYGVIRLLRASTTKTLFEGRITGLKPGKHSLVVHEFGNLMNGCDDLGEPFISNVENNNNNNNNNNNNNNNNNNNNNNNNNNNKNINKCKEILNKIIGTSDVKQDGKAEFRVLSDKYDFWDLIGRSIVLHSQDSKYSPIEDLNNNNNNKNIVNSESDKILGERVACGIISRAASIGQNHKKVCPCDGTTAI
The following text describes a protein:
Function:
Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAALQGLGLAAVWWDRRRPLSQLVLPQVLGLILNLPSPVSLGLLSLPLRRRHWVALRQVDGIYYNLDSKLRAPEALGGEDGVRAFLAAALAQGLCEVLLVVTKEVEEAGCWLHTS
The following text describes a protein:
Function:
Catalyzes the reversible NADPH-dependent reduction of scyllo-inosose (SIS) to scyllo-inositol (SI). Cannot use NADH instead of NADPH. May be involved in reduction of not only SIS but also various oxidized compounds manifested upon stressful conditions.
Sequence:
MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKIMTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVMEKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVSYNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETVDYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPEDDSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEGINVIRIIEAAMESSKEKRTIMLEH
The following text describes a protein:
Function:
N-acetylglutamate synthase involved in arginine biosynthesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MQKPSLSQDLIWILKSVQSRRSTKGFLQKHSSLKDGSPNKKSFAQPISSSFLNRISITKIDDVDSLSDNTLYGIGRSINSLARLGIQSVIVPTSNPIGMTSPFKYLENGTVVAKKRKLSIFEELQQQQNRVIRVSEIFSKAGVLTRPSYSSVCQLGPEGPSVENVQGIFQALSSLYTVIVPSSILMPNVIEVPIDGNEVLAGLTYSLHKPNFGFWVDRIVILDKNGGMPCSKRQTGSSHVLINLAQEFDELAKTLPPYHRKNLILVRRCLKMLPDDASALITTPEDAMLTNPVLDKNPLIHNVLTDRSIISCSLPRDRSPITKTTVLRSGVPVYTFLGPKCLTDGSVSWERLWVLINDSFKRTLDMDAYLDRLKNSLAAVIIAGDYLGTAIVTYEQPDGTTNEKVPYLDKLAVSQGAQGSAAISDVMFNVMTDLFPKELIWRSRLTNPVNKWYFERSVGSLKSSKTPWKLFWTGDSHVRNLDRVNQYMSVIDKIQPTWLN