lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Associates with components of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility, and might act as an inner dynein arm (IDA) hub or linkage.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MIQELLWRLGVPGLLRLFRKNTCGSLRCIVIQSREARGTMSTVVAQSLHVFGLRSHVTNNIFFFDEQIVIFPSGNHCVKYNLDQKWQKFIAGSDKSQGMLALSISPNRRYLAISETVQDKPIITIYELSSIPCRKRKVLNNFEFQVQKFTSMAFSPDSKYLLTQTSPPESNLVYWLWEKQKVMAVIKADIQNNPIYQVSINPQDNTQVCITGNGIFKILRFAEGTLKQTNFQRGESPNCLAHSWVSEDRIIVGTDTGKLFLFESGDQRWETNIMVKEPTSSRSLDIIHESESLVEFPPPSSPASSIEQMSTTTYTQQVVLPQVFAIAAYSKGFACSAGPGRVLLFEKVEEKDFYRESREIRIPVDPQSNDPSQSDKQDVLCLCFSPSEETLVASTSKNQLYSITMSLTEISKGEAAHFEYLLYPLHSASITGLATCIRKPLIATCSLDRSVRIWNYESNTLELYKEYQEEAYTVSLHPSGHYIVVGFADKLRLMNLLIDDIRSFKEYSVRGCKECAFSNGGHLFAAVNGNVIHIFTTTNLENINNLKGHTGKIRSLVWNTDDSKLISAGTDGAVYEWNLSTGKRETECVLKVCSYNSVTISPDGKVIFAVGSDQTLKEIADSLILREIPAFDVVYTAITISHSGRMIFVGTSVGTIRAMKYPLPLQREFNEYQAHAGPVTKILLTFDDQFLLTVSEDGCLFTWKVFDKEGRGIKREREVGFAEEVLVTKTDMEEKAQIMLELKTRVEELKMENEYQLRLKDMNYSEKIKELTDKFIQEMESLKTKNQVLKTEKEKQDISHREHLEDLIERQSRELQDLECCNNQKLLLEYEKYQELQLKSQRMQEEYEKQLRDNDETKSQALEELTEFYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIEERTNDIELLKTEQVKLQGVIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEDELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNCVSYIQEPRQLKEKIRALFEKYVQRADMVEIAGLNSDLQQEYARQREHLERNLATLKKKVVKEGELHRADYVRIMQENVSLIKEINELRRELKLTRSQIYDLESALKVSKKTRAQEAPESVLTKDVVGTSSTMRLNEQEETGRIIEMQRLEIRRLRDQIQEQEQVPGFHTIAGVRLPSLVDSDVDFEVHTK
The following text describes a protein:
Function:
Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits. Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. May function as a ribosomal silencing factor.
Subcellular Localization:
Mitochondrion.
Sequence:
MTAPLVSRFPFRRSILTFVEGGQSCFNDAKTINQRVSFSNQSESKDSNPTSCLVSGIFTGAERVGIMNVVGRSRKVVSLLCRSCGLLEQKCVFRAARSSGLNQQCHHATPLRSRFDTQRWCSGDTDSRLLGSTSSQELSLETDHKNSQTISSGHGDSETFNLDVLVSLLRQENAVDLCVIKVPENIKYAEYFIVVSGISPRHLRAMALYAIKVYKFLRKDGDPNVKIEGKDAEDWMCIDFGKIVVHFMLPETREVYELEKLWILRAYDEQLMRIPPEVLPEDFMLASLDPLCSALPAVSSSAETRETVHRWDVSKLSGSLPAPLFFLRHKRISSQASWSPGRSAT
The following text describes a protein:
Function:
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGRAAPGPDEGAEGERPSISATALARMERNRRRALALRQARLAARPYPQAAAGAGPPQGRDTGGGFFLEEEEEEEEQRRAAERIVHPPAPVLQFDYLICGDCGKEFMDSYLMQHFDWATCDNCRDAEDKHKLITRTEAKEEYLLKDCDLDKREPVLRFIVKKNPHNPRWGDMKLYLKLQVIKRALEVWGNEESLQEAKEQRRDSREKMKQKRFDKKVKELRRAVRSSLWKKTASIHEHEYGPEENVDEETYKKTCTVCGHELTYEKM
The following text describes a protein:
Function:
Negatively regulates yetM expression and its own expression. Binds specifically to corresponding single sites in the divergent yetL and yetM promoter regions, with higher affinity to the yetM region. Recognizes a 28-mer operator of double-stranded DNA that contains a palindromic sequence.
Sequence:
MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVMEHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVSRRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFERLSVFKD
The following text describes a protein:
Function:
Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Required for the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivates genes involved in glioblastomagenesis (By similarity).
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Note=Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (By similarity).
Sequence:
MAAQSAPKVVLKSTTKMSLNERFTNMLKNKQPMPVNIRASMQQQQQLASARNRRLAQQMENRPSVQAALKLKQSLKQRLGKSNIQARLGRPIGALARGAIGGRGLPIIQRGLPRGGLRGGRATRTLLRGGMSLRGQNLLRGGRAVAPRMGLRRGGVRGRGGPGRGGLGRGAMGRGGIGGRGRGMIGRGRGGFGGRGRGRGRGRGALARPVLTKEQLDNQLDAYMSKTKGHLDAELDAYMAQTDPETND
The following text describes a protein:
Function:
Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAAKSKNADYQHKSKLDEHQVQLAVPALFKLLQLNEVKAKKRKLMADDEKIWLNLILKKIPNPTKPIQISLPHSLHPTGTLEICLFCKDNEKDTIKKKLEKDGITEIVKIISIIKLKKNYRGYEAKRQLCQMYDLFLADDRIYHLLPPYLGKKFFEKKKYPIPVSVTKKNLTSQINGIRNSTYFSLGKGKCNAIPVAMTNLDSEKITENIIATVNSIAAKIPRGWKNIQALYIKTTATVALPIYNSIPYESTKINTDNTTKTVKVSLAD
The following text describes a protein:
Function:
Involved in endocytosis.
Subcellular Localization:
Cell membrane. Cytoplasmic vesicle, clathrin-coated vesicle membrane.
Sequence:
MLMFCEVHTVSSSSFLKFSPPSGGLDAVNPNCIVVRDDLRPSISDSWCKMAAEGEYESILCVKPDVNVYRIPPRASNRAYRAADWKLDSPDWSGRMRITAKGKVAFIKLEDKVSGELFAQAPVNEYPGIAVETVSDSSRYFVLRIQDDSGRSAFIGVGFGDRGDSFDFNVTLQDHFKWVKQEIEISKNAHLGDSGPKLDLGFKDGQTITLNIGQGKKRDKPRPQISGGMGLLPPPPGGKIAPPPSSGTCNLNTVPQTGGTETECLLDLDCSNSNTMVQSNANADLLWGDFSAPARFVVFFL
The following text describes a protein:
Function:
Plays a role in innate immunity by conferring resistance to virulent strains of the Gram-negative bacterium P.aeruginosa via the zip-2 pathway and independent of the pmk-1 p38MAPK pathway. Induced as part of several immune responses to translational inhibition arising from endocytosis of ToxA during P.aeruginosa infection or exposure to exogenous cycloheximide.
Sequence:
MFDEFYFRKSLRPRESQNHVRNAACEYILKFMKTEGTIVKTYHLGSSLEPWGRKFHERIDRTVFDQDLTPFVKYTLNKKKRWEAEGNPDILYGLQRSYQNMGVMVAERVSLRSTPHYCIVSINNYYRNFFDQFPIRHLHQLQDHNYQCQSTNSIRGQPFKSLQPENRTPTQVTGHQQESSANVSVAYHIITPPKNYEVLRNKDFRVGHSDRNGIRTIARRRRFQFMKEAVFDLKNEILEDFGDSDDDDENEILLCEESCGPRKFYNLHDHLVKSNHNE
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKHFTTLIVVFVAIKAYLVALALVVPRQYDTSSTLLFPNNRFLSRLVIWDSVFFVSSAERSHLYEHEWAFSWMWSRALGLAGSRDAIAYTAIAVSSLSHLLAALMLRKLTESVFHNKRFAETTALMYILSPAGIFLVAGYTESLFALLSFTGLYLRQRGQYPLAGAVLGASCLLRGNGLLWGIPFLFDLASAIKHNQFNRGVSVVIGGSLVGAVFLYTQYLPWSIFCPERDEWCNYYIPSIYGYVQQRYWNVGFLRYWTANNIPNFLFAAPVLYLMYQSMSTNPSLVPFYTVHAIMGLACVFMWHVQIITRISTCLPTLYWYMAKLAQGYNGHYVVRYIFVWITFQVVMWGAYLPPA
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MKVKDVERTANVAWSPKNQSPILLAAGTAAQQLDASFSTNATLEIYSLNLGELGPDMVLKAATPSEHRFHKIIWGAYESHGTIVGGCDGGLIQIYSASKLMNGENGLICRQNKHTGPVHALDFNPFQQNLFATGAGDSEIFIWDLNNTNTPMSPGSKSQPLEDVLAISWNRQVQHILASTFASKCVIWDLRKNEPIIKLTDTVSRVRWKMIAWHPEVATQLCLASEEDHSPIIQLWDLRFATSPLKTLENHQRGVLSVAWCADDPDLLVSCGKDNRIIAWNPNSNEPNGEVLSEIAKTNQWNFDVQWCPRNPAIIACPSFDGHVSVYSLMGGKTQQIQTTNKIADSFPGMDGYVQAPVLQQSSAPVSVDLSRPPKWLKRPVGARFGFGGKLISFDNTKPDVDQISHRTVQISQVITEPELVQKSTELEQALEYGNFTEYCSRKAETTNDQHTKYIWHFLRANFEENPRAELLNLLGYRIEDVNNKLNQFVHKNKVDGVSERLEDLDPFDAIVDNKTVTKPFKIKTGDDTEGLITQALLLGNVEAAVELCLEAKRFADAIIIAMTGGSDLLARTQHAYLEQCEGYVSSLISALVSEDWASVINNCDLSSWKEALAATLTHSTDEALPLLCEQLGNRLSHGDAKLKQDSQLCYICAGSFDNLVNSWSGNAQNSTSDLQDLVELVVFLQKAVERQGRQVQISGALADLLGRYASILASQGNLSTALSYLGSSQDEKVAALRERLYISLGQKPGYGAQRQAQSRRLSQRQSFSSYPNMGAQFNSGLPNAAVPVSQPWQPQPQMGGFNQQPPARTFSPAPPSQPTRPPSVGSNHGGSGTGLPSRKYVLDPSVTSNPYGAPTRNMYAPQPVSNFQNNNYGAPSPITPLVPSNNNYVPNPVPMVPNPPLNPTPLVPNIQPPPPMTSEMGQPATEKYFPSSAPGWNDPPPLNKPLRPQPKPEASVPSQPITHPLYGSAPTNNGYGTEPQMFQPQPTNNFAPPNNFTPPTTFNPTGFKSNAVNFNQVQNQTPVVPEKPQPIQKPPIPEEHIHMQTVFDELKYQCSCAANNPQTKRKLEDVGRKLESLYDLLREQKLSPNTLGALHQMVQLVQNGDYTGGLNLHTQLVSGPDFAQIASFMPGLKVLLQCALQLQVYLR
The following text describes a protein:
Function:
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MADERYNRKNPAVKRILQEVKEMQANPSDDFMSLPLEENIFEWQFAIRGPGDTEFEGGIYHGRIQLPADYPFKPPSFMLLTPNGRFETNTKICLSISNYHPEHWQPSWSVRTALVALIAFMPTSPNGALGSVDYPKDERRTLAIKSRETPPKYGSPERQKIIDEIHQYILSKATVVPKPLPLECSQAPSIVSEAHSQVEPQEAITVVEERSIATTDTIVDDQIIEETAEAVNTAASVVPAAAPLPAVEVVVKASVSGEQRMARRAAQKPVDDRLFTWAAVGLTIAIMVLLLKKFIKSNGYSTGFMDDQS
The following text describes a protein:
Function:
Plays a role in the inhibition of host protein synthesis. Specifically, inhibits the initiation of cap-dependent and cap-independent translation. In turn, affects the outcome of infection by decreasing recruitment of inflammatory leukocytes and reducing the memory CD8+ T-cell response.
Subcellular Localization:
Host cytoplasm. Note=Localizes in cytoplasmic structures that differ from virus factories.
Sequence:
MLLEMDKIKITVDSKIGNVVTISYNLEKITIDVTPKKKKEKDVLLAQSVAVEEAKDVKVEEKNIIDIEDDDDMDVESA
The following text describes a protein:
Function:
Transporter required for vacuolar uptake of basic amino acids.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MEETKYSSQQEIEGACGSDASLNARGSNDSPMGLSLYLCLASLTLVLFITALDILIVGTIIDVVAEQFGNYSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAALASSMNMLIFGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIGGLAIIMFLLTYKAENKGILQQIKDAIGTISSFTFSKFRHQVNFKRLMNGIIFKFDFFGFALCSAGLVLFLLGLTFGGNKYSWNSGQVITYLVLGVLLFIFSLVYDFFLFDKFNPEPDNISYRPLLLRRLVAKPAIIIVNMVTFLLCTGYNGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVIAAIASGVITKKLGLVKPLLIFGGVLGVIGAGLMTLMTNTSTKSTQIGVLLLPGFSLGFALQASLMSAQLQITKDRPEAAMDFIEVTAFNTFMKSLGTTLGGVLSTTVFSASFHNKVSRAHLEPYEGKTVDDMILYRLQNYDGSHSTIGNILSDSIKNVFWMDLGFYALGFLFCSFSSNKKLIIPKKDDTPEDNLEDK
The following text describes a protein:
Function:
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
Miscellaneous:
MISCELLANEOUS: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
Subcellular Localization:
Cytoplasm.
Sequence:
MQNYQSHSIKVLKGLEGVRKRPGMYIGDTNVGGLHHMVYEVVDNAVDESMAGFCDTINITLTDEGSCIVEDNGRGIPVDIHPTEKIPACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGQIYRQEFEKGIPTSELEIIGKTKSAKESGTTIEFFPDESVMEVVEFQAGILQKRFKEMAYLNDGLKISFKEEKTQLQETYFYEDGLKQFVKDSAKKELLTPIISFKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIGNNIKTKESRPISEDIKEGLIAVVSLKMSEPLFEGQTKSKLGSSYARALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKDNLSVGTLPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESFDIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTEIYLKDSVALDHFLIEHGINSVDIEGIGKNDLMNLLKVARHYRYALLELEKRYNLLEILRFLIETKDALSLDMKVLEKSILEKLEGLNYQILRSFATEESLHLHTQTPKGLVEFNLDDNLFKEVLFEEANYTYQKLMEYNLDFLENKDILAFLEEVENHAKKGANIQRYKGLGEMNPNDLWETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV
The following text describes a protein:
Function:
Peptide which plays a role in the humoral immune response to a subset of filamentous fungi, including F.oxysporum and F.verticillioides.
Miscellaneous:
MISCELLANEOUS: 'Daisho' is the Japanese term for a matched pair of samurai swords, one short and one long, and refers to the role of the two Daisho peptides (Dso1 and Dso2) in defense against fungal infection.
Subcellular Localization:
Secreted.
Sequence:
MNCLKICGFFFALIAALATAEAGTQVIHAGGHTLIQTDRSQYIRKN
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSKKQKQRTKGNVRPSSSGRAAELLAREGGGHVGFVGFGSMSGDLGYVPTSVGFEDQDAGLDADFRMVLRKLSKKDVVTKLKAIQEFQGLCTEKEEEDIVSLLPHWPRLYNRLSMDHDKRVREATQQMFIKVVSRVKRNLAPHLKAIMGCWLMAQNDPYAPAGSGAKVAFRKAFTSQDKQGNAVAFCKGEVLQLYKDNLFKETAETLSDPKSFSKEEQVEKYLRVVSSSLLALREFINLLPEGQLEGSKEELNTILSEDRLWKFVKNQSPEIRGAMYSLLGTLCKVMPSILTPYLPKLCPALLASMDETEPLTVGPLWEGILRLISCDLDCWKHVNMRKAVLPKLWSVLRNGGNGCASTIYPHLLPLLSHLPPEVKSQDEAFCREFFNNFREGLSCKRVSQSISENTAILKSFMECLRYSIAQSLSSENASVHTHLLDQQLMPLLKSSLTEEGKTWSVVTLYQQTGALLNYLYKQKVGDEKGSPARQVLETLWSGISAMCVDHVTSALTNQEAGLNNTALLVAVLKNPNAVEVKKMGASKRRIKGARIRFAVEEEEGGGEIEKQEPSGSNGDDRLGKPQTNNGQSKIEGVESSTEPSIQHPQLPSLVSDLVQSSFHQARDSLPHLHFLAQLVRTFSDRTTIRTMLKAADVNAACPTRTGSDLICIDAASKVDGEDEDAIRTSGDVKNIQDSEKVAGGSGIDKLDARVEKKEEEEKEEDIGSDDDLLPLKCIYSFLLPWLLDVEKDRDARKQEKVLRMEAILDMTVSVLLTVQEENRILVVDAVCLKAETLQLLHLTISKMRDKPELSSTMDTWLQSELFGEKLLSIQDELCRLTLEGQLEQSSVGWKLISLALSSGKHDEPLIGTTYAELLLVGFYHALTRPDAVTTATQCISFICDVTSNFFSAVKGCIHLSSSTDLLLAIFQLECRDAQNLSGSLKEKVRQTWAQGVQSLVKQTGGLLTDQGLLVKTTQWIKQTLNEKEGNIHQFEQLGLTASAFLAAILDGLPGNHDDSDQDVMKTLLESLLPSENEWGSHRLELANQWISSAVIGQQMTQCDPPPLTPTDTTHAPQALKLALFVSTLTSDLNKKVQTIGASSGEEHGQEDGEEGEVISMETSGLPWECDALQSAIVEVMYMREWCQAITGIEAAPLKLAAGTAVITSPPDYCLQFPQTFSQATEDIWGHLTPPLWQELFGIVFDRSLKSGGLWSYVLDRFIDINFKHNDEKARINIWQPMDSPNEPWLEICSVEMLQTVERLVPHFSDRQCQDLAGCHAGMLVSCEGDWITSLCGGLTNLTVLVRCITMNRPGPGALPDLALSTLRQLQHWREKSNSVFLFSGEELEGASSEQLCLNIKMVQLVTCVVEKIPEELESHDWDFILCSLVSWVQACSDNMASIKSSSILASTLCAATSDLLSSTSRLFGQSERSVKLPSSLLTEWNEFFSDGAYSVFLPAFMRFIEEESLWSAAGVDLTPLLYALCEAAAYTPTEQLKGHCLPPKLQPGSTRHVPDPLHSLLNHLVALLTKPYRPVQTAAFNMLQRVMPEFARYDEEYLQVKNKTQADDEDEAPSILPPTGLQKLLDSSTAFMEALLHDIPVGECTVVETGSEAYMQTCSYLLAWRLYLTIFRAASMEVRAQYSSYLKQTKGIHSLLESLFCLMPEDPTLERSATPSKGSQVTMFSKHPDLSPKAASHVEVNEVQHLACSVYFSILQDVPAIARQWWTLQDRRIAPYVDRFTTKYISPLLCAEEMRSVQENPSTAENMTVKARLSTREVIATYSMQELNIEMMITLPANHPLGPIEVDNRRKVAVGTSQWRQWTLMLTTFLTHQNGSIMEGLNLWRSNADKRFEGIEDCMICFSVIHGGNCSLPKLMCKTCKKRFHSACLYKWFSTSAQSSCPLCRSPF
The following text describes a protein:
Function:
Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11 (SPO11-1 and SPO11-2), mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.
Subcellular Localization:
Chromosome. Nucleus. Cytoplasm. Note=Localizes to meiotic chromosomes from leptotene to pachytene. Mostly present in the nucleus, but also present in the cytoplasm.
Domain:
Despite a weak sequence similarity, retains most of the structural features of the ancestral archaeal Top6B subunit (AC O05207), including the transducer domain that interacts with the SPO11 subunit and the ATP-binding fold, also named GHKL fold.
Sequence:
MENNAPVPKLLLQLISSAFQRCRLAEDLCRLSVLLDQSTERDPPITCISIADTGIGCNLEEFQNLRCPREFNGAKIWDGLLSVKTTCFTDDEVYYYHINLDEYIANKRLKRQPSQAKNGAKFSGTEVSLSVFGSMDVLVAPIIGFFQKIIVLQILNVTLDLMVKQGTSPGNQTQYVFAVNADKTPCFTASNLERLKSGLEDYVLRHANCLDTMCDYCFSDREHLKVGSGTVCQEDKHKRVGGTMEVVIVISDLLESTQHCSRSCNGKTEVLYFDNFLPSPVPHLALSALKKIDWKKYGLILANVNDQDGHVFLEWDNFPSYVQIQIALHWYHNQYPTRQKNGPGISLLKKGIKNALDNLKAKHEGFLLSSHSRKICSYVPDLARSIAGLIFSSTDLDFQGDCLSVLGFQTQEVERDTVENYIQRKIVTVIGMNERKPQKDQEAAPFLFFDGESETSFFEDEEVEGEYYSSSLE
The following text describes a protein:
Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
Sequence:
MGDLFIGCLSTGDFIWSKLKDLQYGIRSKLGVYFSLLYCIFYSCMQIFMMNLSTTFICEFSKDIWTTFLEMRLKQEHFLKLKAGSFEDFSLAKSIIKHKRITVITQGADPVCVVESGKMKLYLVILLPKDKLVDTNGAVYNNNLIIFKINFKWPKIIIL
The following text describes a protein:
Function:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity). Required for normal polarization of epidermal cells, correct subcellular location of the Crb complex to the apical lateral membrane, and for normal neuronal development during embryonic development. Contributes to maintenance of epithelial cells in response to topoisomerase-1-mediated and oxidative DNA damage. Required for precise axonal bifurcation in mushroom body neurons. Required for maintenance of normal neuronal function.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MKECPYGEKCYRKNPIHFGEFSHAHLDAIYAKGNESGDYEIPANYSSEMIHTQLKLLEKLFPKQATNKEQEAHSSSSKPAVTAPVASGSSSSGSLDTNPSGSSASGPAASQDTSNLAKKQKLNAKNIRDYIPVVIEKGGMAKKLERAAPYNMFLTAITDSKPTHSEPLSITLQEILDESLGEIESTVQINFMVDIGWLLGHYYFAGILDKPLLLLYGDESPELLSIGKFKQQVTAIRVKMPTPFATSHTKMMFLGYSDGSMRVVISTANLYEDDWHNRTQGLWISPKLPALPVDADTGAGESLTGFKQDLMLYLVEYKISQLQPWIARIRNSDFSAINVFFLGSVPGGHREGSVRGHPWGHARLASLLAKHAAPIDDRIPVVCQSSSIGSLGANVQAWIQQDFVNSLKKDSTPVGKLRQMPPFKMIYPSYGNVAGSHDGMLGGGCLPYGKNTNDKQPWLKDYLQQWKSSDRFRSRAMPHIKSYTRFNLEDQSVYWFVLTSANLSKAAWGCFNKNSNIQPCLRIANYEAGVLFLPRFVTGEDTFPLGNNRDGVPAFPLPYDVPLTPYAPDDKPFLMDYLQG
The following text describes a protein:
Function:
Zinc chaperone that directly transfers zinc cofactor to target proteins, thereby activating them. Zinc is transferred from the CXCC motif in the GTPase domain to the zinc binding site in target proteins in a process requiring GTP hydrolysis.
Sequence:
MPKIPITLITGFLGSGKTSFLSEYLNQTDHQGVALIINEIGQAALDQRILSVQYCGEKMLYLNAGCVCCNKRLDLVESLKATLNNYEWHGEILRRIIIETTGLANPAPILWTILSDTFLGVHFEIQSVVACVDALNAREHLTNNEAKEQIVFADSVLLTKTDLQNDSAALTKLKERIQALNPSAEIFDKRAIDYESLFSRKNRARNFMPRMPKDSHSQGFETLSINFEGTMEWSAFGIWLSLLLHQYGTQILRIKGIIDIGSGFLVSINGVMHVIYPPKHILKDQNGSNLVFIMRHLEREKILNSLKGFKDFLGIKGFETQ
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (By similarity). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Mitochondrion.
Domain:
The U-box domain is required for the ubiquitin protein ligase activity.
Sequence:
MKGKEEREREGGGGAVGPGAAGPGAGGGSPEKSHSAQEHKEQGNRLFGGRKYPEAAAAYGRAINRNPLVAVYYTNRALCYLKMQQHDKALADCKRALELDGQSVKAHFFLGQCQMEMENYDEAIANLQRAYNLAKEQRLNFGDDIPSALRIAKKKRWNSIEEKRINQENELHSYLTRLIMAEKERELAECRKAQQEENVDESRGRVQLAGIEAKHDKYLADMDELFSQVDEKRKKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTRSPLTQDQLIPNLAMKEVIDAFISENGWVEDY
The following text describes a protein:
Function:
Folate transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEDSDKENTLLLPNNKYRNQNFIRNQDEDENENENNDNLENDNNKRNYISINNYEPYKEIDNNNNKNNNNNNIINNNNKINFYNNLIPRIKSYFQEIKPFLKYCSFSFLFSFDPSEPYLVDYFTNVLGINQTIVYQEIYPYWTYSYFVFLLIFGILGEIIGYKVIIIIGMVAKILTIGVLLSTNNIIWMILEQITEGLSYSAYTVFLAYIYFSLDTSEYQKMACRVNAGYLVGIVSSGLLGQLLVEQRLPLVYLLSIACGTNILALILALGFSNYKIDQKFSLKEVISDLFGTFKNADIVRWYIWSGIAISIHQIVITYWQNLFLQVNDEQSWNGYISASAYFFASFFAIIPSKLGNKINNIQGIILVLFGLLGGGLLVLMGFGGSTVVSALSFIIYNCCFEFVSPIVNVQIAKKLSSRIGVLFSFNIMVALTIQVLVQSAVGKQFLNLDIKTQFYYYGACLFFLSFGFAILFGFLFLKKKINSNSNSNSNVDVLIVNHNTQNQNSEEKKKKKELYYNANIIDFENNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNVGIGGNDNFK
The following text describes a protein:
Function:
Required for maturation and cell surface expression of acetylcholine receptors.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPKLTDRNRDRDREKKKRRRRDDSYDDYEEEGGISGWKLGLVVGVIVVCFAMLYPTLFHPMLMGFLGRSSQPAPSINQQRPPIHPAMGGGGGQRHPGGYPSRPDVHPAMRMAQAQAEGQSGGSKGMFTWMLPIYTIGVVLFLLYTLFKSKGKKAKRKKRNYFDSEDDSEDSEMETKYGGKFGKKKLKGLQERLRQTEDAMSKILEQLESVQAGANPVDLDAADKLALELEEDKSAKEAVGLTETNEQYIKDLEVALKEFQSLSKAYDKEKMKKLKRKDSSSEEEEEEEEEEEEEEEELSELSEVEEEEEEKPVKKGKKVVDQKKPAKKAILRQKSTSEEEEETRIADKKAEEEEEEGIDIDFEIREHAERNKKDKNLRRRRPKKT
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MCKRNLEVMDSVRRGAQLAIEECQYQFRNRRWNCSTLDSLPVFGKVVTQGTREAAFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRACRPSARWATHSRRSLTVPPRWSHAVWAPPGRWCRATRSSSRIQMRTWCTWSPARTSASRTCAAACWAQGAARATRRPRPLTAVSCCAVAAASTQHRWSWPSAAAANSTGAASSSAGSASGWWSCTRAGDRRLGLRPQPPSGPGKADNLNSPHHPPQKILVVFFVLVWFLGPHVIYCQNQAGDPSSTDWGLPKAWVFVAATDQRDLAHASGCPHVDAADHSVAICNRFSTCRLEVGNEECYSHMPTGPAS