lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MATELSSSPAPVLSIKHQTFATLKKPHISSLSHFLSKSHRRCNYSLSISKHSCIFRVSCQSQATDAELATRVGQDRLLKVPASNIRNFSIIAHIDHGKSTLADKLLQMTGTVQKREMKEQFLDNMDLERERGITIKLQAARMRYVFENEPFCLNLIDTPGHVDFSYEVSRSLAACEGALLVVDASQGVEAQTLANVYLALENNLEIIPVLNKIDLPGAEPSRVAREIEEVIGLDCTNAILCSAKEGIGINEILNAIVKRIPPPSNTAGCPFRALIFDRIIMLMKLECYPPIKCKWKNFKQVGYLSASIRSVADARVGDTITHFNRKADNLLPGYEEATPMVFCGLFPVDADQFPELRDALEKLQLNDAALKFEPETSSAMGFGFRCGFLGLLHMEIVQERLEREYNLSLITTAPSVVYRVNCVNGQTVECSNPSLLPEPGQRRSIEEPFVKIELLTPKEYIGSLMELAQDRRGEFKEMKYFTESRASLIYELPLAEMVGDFFDQLKSRTKGYASMEYTFLGYKESQLIKLDILINGDCVEPLATIVHKDKAYAVGRALTQKLKELIPRQMFKVPIQACIGSKVIASEALSAIRKDVLAKCYGGDISRKKKLLKKQAEGKKRMKAIGKVDVPQEAFMAVLKLEKEVL
The following text describes a protein:
Function:
Plays a role in vesicular protein sorting.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MQLSAGEQNSILQSCIANINQQSNLMKHDLNENKLLPALKHCSNFLNELRTNSLSPKQYYEIYMLVFDSLETLSTYLLNSHTARQKSKNREAKGNDTIKNGKPENDGEGTSAFLADLYEIVQYSGNIVPRLYMMIVIGTTYMSIEGSPKKDLMKDMIEMCHGVQHPIRGLFLRYYLSQRTKNLLPFQNQIDFEETVEFLIKNFIEMNKLWVRLQHQGHSSERELRYRERKELKILVGSNLVRLSQIIDDYNGDANYSAIEYYKEKIFPIITEQIIQCRDHLAQSYLIDVLIQVFPDDFHFATLDKLLNEVFVNLHPLLKKSELVQTLIDRFIAYHKFSSDMNKLSIEETGSNVIEINVDQLFQSFWQFYNKLVATADPQLPPEEHSMLLQSFINLLLTFEPDDFSNLDIIYKFAEENLAAQENNSELEQEMWSQLLLVPVSHFKSIKTLLSLENFYHFYTKLDNKALQKQIAIAIVDRILEIASDNDNELLHSVDEIDGVFKYLMVLIKESPSKLDTAKHLGVTKTIKVNNGEALITEEFLETQEKICKLIHLVELSDDPIKNVSNLMYVRKKYLNKNFENIIHTYPTLISKILFKLKLAGYVNLHQRKKSRSDTVDLQITSNFKNLSVIIDELYQYHQEYSSELILNIYLNVATVADQLKLESICYELFNQCFVVYEENLILTPHQYKTSSTTTHINPHDSLSGGSLAYESVLSIANTLVKTRNFSKENYENLITKLTLYGSKLLKKQDQCRAVYSCAHLWWWSETLLPAGEKSPTVIDDKDETMNQDNNENSKGSEADADAEPEVESKVEPKLEEPNEELVLYRDPKRVLECLQKSLRVADSCMDPYLSLKLFLEILNRCLIFNVYGNSLIDTRYINGLIDLINTNIDNLSDDKGHDEDFDDADGNDDDVTASEDNKEVLLLKQCRRYLKRTLSYISGQSLI
The following text describes a protein:
Function:
Has been proposed to be a redox modulator.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNTVGTPLLWGGFAVVVAIMLAIDLLLQGRRGAHAMTMKQAAAWSLVWVTLSLLFNAAFWWYLVQTEGRAVADPQALAFLTGYLIEKSLAVDNVFVWLMLFSYFSVPAALQRRVLVYGVLGAIVLRTIMIFTGSWLISQFDWILYIFGAFLLFTGVKMALAHEDESGIGDKPLVRWLRGHLRMTDTIDNEHFFVRKNGLLYATPLMLVLILVELSDVIFAVDSIPAIFAVTTDPFIVLTSNLFAILGLRAMYFLLAGVAERFSMLKYGLAVILVFIGIKMLIVDFYHIPIAVSLGVVFGILVMTFIINAWVNYRHDKQRGG
The following text describes a protein:
Function:
Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B.
Sequence:
MSEGPIQAQSQSLVSFLIFLRSTLKLVDPPATMDLQQKQACWKLELEVIDNDSSWVSKFDPSKKKKKKKQKPLIREDDIFFQNGGHFTEDNLPDCQSSRKFEPDYGYKELLSMVFDRLREEDVEVSTERPRTVMMPPQLLAEGTITVCLNFADLCRTMHRKPDHVMKFLLAQMETKVSLNKQQRLEIKGLVSSKDFQAVFRKYIDAFVICVCCKSPDTALAEEGNGLFNLRCETCGLVAPVDIPNLL
The following text describes a protein:
Function:
5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
Miscellaneous:
MISCELLANEOUS: Present with 11700 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MRKCKIFVGNSHPELGNMVCQRLGIEPAPCTLKKFANGETSVQIGVSVRDEDVYVIQSGSPSINDDIMELLILVSACRGGSARKITAVIPQFPYSKQCKMKRHRGAITARMLANLLVMAGADHVVSMDLHASQMQGFFTKPVDNLYGGPSLAKWIRENVEDYEDAVVVSKNPGGTKRVTALADSLKINFAMIHTDRRRSKDLYSQNKDLQQLKLRKQSMLRKNRPIIRQGDHPNEEENIILSNGIQTARIRNGHVIGDDEADDDEDAILESDSELHSIDGLDSHGLGGTYDAVDSEDEEEIPVLYREQLITLVGNVRGRSAIILDDMIDRPGSFISAAEHLVQNCGAKKVYVVATHGIFTGDCLEELEKSDAIDTIVVTNTYPISGERIAGSKKLVTIDVSPIFAECIRRDHYGESISVLFDSLAAL
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MLSRICGNGIRLTRTRLQFQPSIVTFRDYSNPAPKRGFLNNLIDNVRDEMQKNKELQEHQQQLKARMQELNESDALKDARKKFEIVEKETLKSSEVVKQKIEELSDHMKKMVHEIQKTEAGKKMTEAGAEALKQARKAAEHVEKVAEKVGDTEVYKHVSTSMKTVKDEIDNIADVRMYSRPEALTKRTDGFDLEKERVVEANDSATDVTLHKDSKWYSGWKNFSESNTYYHKLLDWKIKYDESDNMAVRMMRGVTEKIGSVFSGQNEVSEVLTEIHKIDANFDKQEWLRFCETKIIPNILEAFIRFDLEVLQSWCHERAYTQLSTVVKEYQKMHFSTKDSRIIDINKVEMATGKMMEQGPVLIISFQVYMINVTKNADGKVVEGDPDNPKRINHIWVLCRDVEEYNPALAWKLLEVHMQETPLAL
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.
Subcellular Localization:
Nucleus.
Domain:
The JmjC domain mediates the demethylation activity.
Sequence:
MPINSESCPLCKVHSNTIKKEDEDEEDNKTSWIQCSKCKVWYHVHCLDLPTDEIDQIVIYHCPECVPKYGESTYKRKSKRARVSIDYQSLNEGDTFAIDKSSHFHLHNFLNFKGETNINVIDKLTKTYALNTQMEKPILIPQADLSKNGMQLPIEKNEITIDYITDCCGEDTPLEVMDVISQQGISPPWKLKQWREYFKTNEEKRDRIRNVISLEISDVAKLGVDFTRPKCVRDMDVVDRVWIEEDEQKRSKVTKYCLMSVKNSFTDFHIDFGGTSVYYTVLSGAKTFLFFPPTDNNLELYKSWCLEPSQNFIWYPEYTITKNKKKIKPTGGFKVDLQPGDLFIIPSGWIHAVHTPQDSIVIGGNYLTIRDMVMQLKINEIERETKVPTKFRFPMFNKVLWLTAWYYYNHQNEFQSDIGEDEDGNAILTRLIGHLQGHLELSKTNATAKRSIPKTIGKPMVFINKLLAWKEDLYGTAV
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MVGYRQKWVQDLPPAGGFPKLKYARTSTSPIPGAYIFAGVFSIMAVGTYIFFSDKVERNAREEEEKRRLSMILPILQAENDINFLASPHQNVYFTRWMPPQTGKRAAALLRDL
The following text describes a protein:
Function:
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Acts as a attenuator of EGF signaling, facilitating ligand-induced endocytosis of the receptor and its subsequent desensitization. Mechanistically, modulates ligand-induced ubiquitination and trafficking of EGFR via E3 ligase CBL phosphorylation by PKC. Increases cell-matrix adhesion by regulating the membrane organization of integrin alpha4/ITA4. Modulates adhesion and suppresses cell migration through other integrins such as the alpha6/ITGA6 and beta1/ITGB1. Decreases cell-associated plasminogen activation by interfering with the interaction between urokinase-type plasminogen activator/PLAU and its receptor PLAUR (By similarity). Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. Plays a role in the restrains phagocyte migration but supports macrophage activation (By similarity). Plays a role in TLR9 trafficking to acidified CpG-containing compartments by controlling interaction between TLR9 and VAMP3 and subsequent myddosome assembly (By similarity). Inhibits LPS-induced inflammatory response by preventing binding of LPS to TLR4 on the cell surface (By similarity). Plays a role in the activation of macrophages into anti-inflammatory phenotypes (By similarity). Independently of Toll-like receptor (TLR) signaling, is recruited to pathogen-containing phagosomes prior to fusion with lysosomes and participates in antigen presentation (By similarity). Also acts to control angiogenesis and switch angiogenic milieu to quiescent state by binding and sequestering VEGFA and PDGFA to inhibit the signaling they trigger via their respective cell surface receptor (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGAGCVKVTKYFLFLFNLLFFILGAVILGFGVWILADKSSFISVLQTSSSSLQVGAYVFIGVGAITMLMGFLGCIGAVNEVRCLLGLYFVFLLLILIAQVTVEVLFYFNANKLKQEMGNTVMDIIQNYSVNASSSREEAWDYVQAQVKCCGWVSPSNWTRNPVLKNSTKTTYPCSCEKTKEEDNQLIVKKGFCESDNSTASENSPEDWPVHPEGCMEKAQAWLQENFGILLGVCAGVAVIELLGLFLSICLCRYIHSEDYSKVPKY
The following text describes a protein:
Function:
Positive regulator of myogenesis. Acts as a cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly. Proposed to contribute to the maintenance of muscle cell integrity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (By similarity). In vitro can inhibit PKC/PRKCA activity. Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm, myofibril, sarcomere. Note=Nucleocytoplasmic shuttling protein (By similarity). Mainly cytoplasmic. In the Z line, found associated with GLRX3 (via C-terminus).
Domain:
LIM zinc-binding domain 1 is required for self-association. LIM zinc-binding domain 1 and LIM zinc-binding domain 2 both are required for optimal actin-bundling activity. LIM zinc-binding domain 1 mediates binding to MYOD1. LIM zinc-binding domain 2 mediates binding to SPTB.
Sequence:
MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRRYGPKGIGFGQGAGCLSTDTGEHLGLQFQQSPKPARAATTSNPSKFSAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTQQVEKKE
The following text describes a protein:
Function:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Subcellular Localization:
Nucleus.
Sequence:
MGKKETRARKPKADPDAEGSAKMCKASALKKVFFMSEELLPKDADDGHLRLEMFFHPGHGKEALFITHPDGRMMELVAFTEPRRSWFVDSEVCSNGRIYMTAPVDPTFLALHHLRKHCAQRAISLDNIAVEEASTSRLLNEILDPGNLKCVADVKSSGEQKFYKYNQERTLAWLALKTRQVAKILKEKQVHCGHSAQSQNFVRSEKLVAENVSNEMDYTRMACDYVGRYLDADLHGLLTSYLHIPSEIQAIVEEKAASQKRKSVAGKNEGSDSKKIKLNESDAAAKLKSSGLVDSDGDPNATITSPTAAPLKERSLTAKEKALAKGAKGTKSIASFFKAK
The following text describes a protein:
Function:
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKKLFLFFTLIFTAFAANSGLFDKKQTFLKVDDAFAFSATLSTDKSQLQAHWDIADGYYLYQDKISAELVGKSNPLSLHTQQAAELHQDPYFGEVKVFTHSIDGIFRGAFNNADDKVEITYQGCTEGFCYPPETKVLRIGDLVVSQKQIVEKTVEKNTALLSEQDRLADGLFHSKWAIFGFFVLGLGLAFTPCVLPMLPLLSAIVIGQQQRPNMMRAFSLAFLYVQGMALTYTLLGLAVAAIGLPFQIALQHPYVMIGLSILFVALALSMFGLFTIQLPNSLQNKLNTWSQKQTSGAFGGAFAMGMIAGLVASPCTSAPLSGALLYVAQSGDLFTGAVTLYLLALGMGVPLMLITLFGNKILPKSGEWMNTVKQTFGFVMLALPVFLLSRILPEVWEPRLWAGLATVFFIWFALQMSKNGFGYAIKIISFALAMVTVQPLQNWIWQTQTTTQSAVENMPVSQVKFKQIKNTEELDRTLAENPHSIAMLDLYADWCVACKEFEKLTFSDPQVQQQFQNILLLQVSMTKNSPENKALMERFNVMGLPTILFFDQQNNEIKGSRVTGFMDADAFSNWIEKLL
The following text describes a protein:
Function:
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
Subcellular Localization:
Secreted.
Sequence:
MKLMALQLLLWHSALWSGQEAIPLLTVSSLPPSLPLPRSFLLKSLEQVRKIQARNTELLEQLCATYKLCHPEELVLFGHSLGIPKASLSSCSSQALQQTKCLSQLHSGLFLYQGLLQALAGISSELAPTLDMLHLDVDNFATTIWQQMESLGVAPTVQPTQSTMPIFTSAFQRRAGGVLVTSYLQSFLETAHHALHHLPRPAQKHFPESLFISI
The following text describes a protein:
Function:
GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.
Subcellular Localization:
Secreted.
Sequence:
MQVGVIQRTALLVLCCLLLSASSSPVYPALKFGRHADAIFTNSYRKVLGQISARKFLQTVMGKRLGPETESNVKRQSSMYGNTYKQDVDMNVIESEQSYRDPQKFKFALIMH
The following text describes a protein:
Function:
Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MASRSGNKSTGSRRASSQKRGKSSAKGGWRIVLRPEHQRELFALGLMLVAVLTIIFVFTGEAGGLGTLYLNTVRSLFGAGVFFVPLTLFMIGLAILWQERMHDASLSGANVLGTGMILLAMLGLLEVPVHSILIADRMNEGGGWIGYWLLELLQMAIGQIAAVLVILALGLAGLLLTFNLTVRELVVGMVERTIAFWQVLWSAPRRPQSSPATLPRSGADLVFSPPPQGGSDDDIVPTPIAARPTRASLFQRPTPELPPPAREPAVSVKPITPVKPEPVQEVVQEPLDGFEISPVRRAWPLPSLDLLLERTVDGGITDEERRLKARVIEETLASFKVEARVVGVNTGPAVTQFELQPAVGVKVAKITTLERDLALALAAQSIRIEAPIPGKNVVGIEIPNSAIAMVSLREVLDSEEFETFRGRLKLPLGKDVSGTPVIADLTKMPHLLVAGATGSGKSVAINAFLCGLLLKHTPDELKLILIDPKMVEMIVYNHIPHLLSPVVTEVERVVPTLKWATREMERRYKVFARNGCRNIDSYRQLARKRADLEPMPYIVIVIDELADLMMMAADEVETYICRLAQMARATGIHLIIATQRPSVDVITGLIKANFPSRIAFAVTSQVDSRVILDVPGAEHLLGRGDMLYMAADSAKLIRIQGTYVADREVERIVEFWRHAAPPTEATAAQPNTATGEGKAAEESSGAEPFRPPAEFLSPAEQDELLPQAIALVGQHQRASASLLQRRLRIGYSKAQQLIDLLEQQGYVGPAEGGRSREVLKRNGSATS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDPMSPEIHGWSILQKLNEQKSMGLFCDVSLMVEGKIFLAHKNVLSACSEYFYAALSRNEQQQFLVLDNVRLEGFSHLLDFIYSYKIPTCHVQDFMQAAQVLQVSLPLTVQVVNVSSSPQTSTAKEDISISEENFDVRNRGSESREFESQQLRRGRDESTPSVNAVMYSEEIRRFDTVAQMKEKAKIFTRPAFYKDNYVTRNPNFFVHKSVAISGRMANSMDEPRETSFPNTSFARQLPITIHNDGSSEEADDENGDMCINLCDEPDTPDSLEPPLTLNDLSRHGESMSPKVYSTIVGIEGSEVIERIDGDADVVHKCDRCELLLTYSEFLNHQDDPGINILQCEFCDKQFNYSCQLSLHMSSHHNKKFYQCDQCGKELSTLKKLHDHIAYHSDARPHKCRLCDKAYKVKNDLTQHIRVKHLEASNGKAPLLQLCEFCGQAVKHYKSHKIFCSGIKKFKCDFCVQSFHRISELKRHTWTHTGELPYRCKICGKGCRHPSNMKKHIRTVHKADMRVQINREHASPRFCKNRRPPTKLPGQILQQTLPTDLSVMQTAATIVPNQVNQMDSSLPPVSVGYISISTMPENTGNDFSLFSTQNFSAEPTRPL
The following text describes a protein:
Function:
Component of the oleanane-type triterpene saponins (e.g. saponarioside A and saponarioside B) biosynthetic pathway, leading to the production of natural products with detergent properties used as traditional sources of soap. Glycosyltransferase that mediates the conversion of quillaic acid (QA) to QA-mono via the initiation of the C-3 sugar chain.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MSPHNTCTLQITRALLSRLHILFHSALVASVFYYRFSNFSSGPAWALMTFAELTLAFIWALTQAFRWRPVVRAVFGPEEIDPAQLPGLDVFICTADPRKEPVMEVMNSVVSALALDYPAEKLAVYLSDDGGSPLTREVIREAAVFGKYWVGFCGKYNVKTRCPEAYFSSFCDGERVDHNQDYLNDELSVKSKFEAFKKYVQKASEDATKCIVVNDRPSCVEIIHDSKQNGEGEVKMPLLVYVAREKRPGFNHHAKAGAINTLLRVSGLLSNSPFFLVLDCDMYCNDPTSARQAMCFHLDPKLAPSLAFVQYPQIFYNTSKNDIYDGQARAAFKTKYQGMDGLRGPVMSGTGYFLKRKALYGKPHDQDELLREQPTKAFGSSKIFIASLGENTCVALKGLSKDELLQETQKLAACTYESNTLWGSEVGYSYDCLLESTYCGYLLHCKGWISVYLYPKKPCFLGCATVDMNDAMLQIMKWTSGLIGVGISKFSPFTYAMSRISIMQSLCYAYFAFSGLFAVFFLIYGVVLPYSLLQGVPLFPKAGDPWLLAFAGVFISSLLQHLYEVLSSGETVKAWWNEQRIWIIKSITACLFGLLDAMLNKIGVLKASFRLTNKAVDKQKLDKYEKGRFDFQGAQMFMVPLMILVVFNLVSFFGGLRRTVIHKNYEDMFAQLFLSLFILALSYPIMEEIVRKARKGRS
The following text describes a protein:
Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSMNSSTEISQEPSIMKPVSSISSFVFNAGFLQGTFSDTTLIIKGETYHLHALFLGRSPVLLQKLIENNPKGDVHYTIEVETEDPYVTKESCLFVLSTLYCDSPRIPAEVNVCSVLAVSDLLGLDTLAFEASSLIEKSIRPETMESVIRFLDPNFEGLERLKMGMYPRFTSGLFNKAIQVMYNTLVSNWNTEYARLLCNLPFEVIKDLLESDKLTVGASSMARYKLANEIVKMRASFRKQNHIEGKGDESVVLAFDEGSRGIQLVHIAPGAESRRKIWKATSVR
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MNSSIVSQTLTSAHTRYVKGLYRRSLRLAESWYWQRPEQRETCVKLRALFDNDKILTNPKEIELTLLNAERLLALNAHPTPYIAPSGFNGTSWERNLPIPEELIRRGVTPVDNS
The following text describes a protein:
Function:
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRTFYVTTPIYYVNDVPHIGHAYTTLAADVLARYKKLKGYEVFFLTGTDEHGQKVEKAANTAGETPLELADRVVKRFQGLWEKLDIQYTDFIRTTQERHKKGVSHIFTKIMAQGDIYLGEYEDWYCTPCETFWTETQLIDGKCPDCNRPVDKLKEESYFFRMSKYQEQLLAHIEANPDFIQPKSRRNEIISFVKEGLRDLSVSRTSFNWGIPVPGNEKHVIYVWFDALTNYITALGYPDEQSAFKTFWPVDVHLIGKDILRFHAVYWPTFLMAAGLPVPKKVFAHGWWTVEGQKMSKSLQNVVEPNMLVDRYGIDAVRYFLLREVPFGLDGDFSHAALVHRINSDLANDLGNLLNRSTAMVNKYFDGVLPAPGPQTELDTAFREKTEAMVRQLDACMDELAFSKGLQAIWEVISAGNKYIDETAPWALAKDPAKREYLGTVMYTLLEAQRIVHLVLSAFMPRTSAKALGYLGWTEPCREEDLAWGRLAPGTLIVKAEALFPRIEEKEEK
The following text describes a protein:
Function:
May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTTKRAYKLQEFVAHSSSVNCLKIGRKSSRVLVTGGEDHKVNLWAIGKPNAILSLSGHTSGIDSVSFDSSEVLVAAGAASGTIKLWDLEEAKIVRTLTGHRSNCISVDFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVKLWDLTAGKLLHDFKFHEGQVQCIDFHPHEFLLATGSADRSVKFWDLETFELIGSAGPETTGVRCLTFNPDGRTLLCGLHESLKVFTWEPIRCHDAVDVGWSRLSDLNVHDGKLLGCSYNQSCVGVWVVDISRIEPYAVSNVSRLNGHSESKSSSSGNLSVPNENTAKGSGGRLSISQNSDPSVKEIKSLGRLSVSQNADPIKEPKVLAPPGSVPATPQRIGLNATPKTIPASSVAVPSGTAPKRNSTKVPSTASVPVINKLDVIPVIVPRTNMRSEQAAESRREVSVAGRAMPFTFQSKASDFRKFPNMRDEVDKLIVSVAPEFSGSKAVELGNGADRNIFHAVKSSIQGISAAEKSLKDDRFVGSGKQEVNSMTETVASYQHENYDACGHKVKKDACSIESERGGRTRSLVVNWEKRERSPTYEGPTSCIPLGTVSAAKMLPFNAFKQRGYLPSSEKEMVSASDDDGIADVMEQHDQFVSSMQSRSAKLQVVYRYWERSDVKGVVGAMAKMADHAVVADVMSIMTEKIDIVTLDICTCLLPLLILLLESDMDRHLSISLDMLLKLVRIFGSVIYSTLSASSSVGVDIEAEQRLERCNLCFIELEKVKRCLPALARGGSVAKSAQELNLALQEVSQTK
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MYAYAAAPSSSRLATAAAFVVVYLSLQLLVRHFGAAAAQELGRRPGSSWFTHARAQRHEEDFSYRRDAGNGPARWGMIRRDWATCSVGLMQSPIGLTDTVAGLSDRPGHVGRSYRPAAASLVNRGHDIMVRFNTDPGGVVVDGVAYRLRQMHWHAPSEHTINGRRYALELHMLHQSDANNNKYAVVSQLYRVSRHHRDRTIRRLERYVRRVARRKDHEELIDEEVDPRRPVSRSLAYYKYMGSFTTPPCTEGVTWLVAHQVINKS
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSVPAEQLETFLPSELHFMAENETIEILPRRVGNPIKLAGTDLPLMHPLRKNRVPIWMAIALKKQQRCQFVPPDWMEESNLRRILAFEHANPTAFSNVDFHWLEIAQIVLTTAPDDLTSPPQVIRNLVRDIREVREQKSRQGMKEVNENMLQMDRLGALEINEMRPFVVEGMEEMIKIRKAGKKEEPIIYSESDNPEDDEDDEPTYGHDDESSLAVPSSQLDSSLRYGDRVDTSERRRELSQWDDNVPQQGGPEW
The following text describes a protein:
Function:
Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion (By similarity).
Subcellular Localization:
Mitochondrion. Membrane; Lipid-anchor.
Sequence:
MGAAVARAVRNFNLENRAEREISRMKPSPAPRHPSTKNLLLEQMSSHPEIKGEIDRKDDKLLSLLKDVYVDSQDPVSSLQVKDATARQKPKEFRLPKDHQFDMMDVKNIPKGKISIVEALTLLNNHKLYPDTWTAKKIAEEYHLEQQDVNSLLKYFVTFEVKIFPPEGKKAIESK
The following text describes a protein:
Function:
Catalytic component of the mitochondrial inner membrane peptidase (IMP) complex. IMP catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. The two catalytic IMP subunits seem to have non-overlapping substrate specificities. IMP2 substrates include nuclear encoded CYB2, mitochondrially encoded COX2 and cytochrome c1. Required for the stability of IMP1.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MFRAGSSKRFLRNTLIAISWVPVLLTINNNVVHIAQVKGTSMQPTLNPQTETLATDWVLLWKFGVKNPSNLSRDDIILFKAPTNPRKVYCKRVKGLPFDTIDTKFPYPKPQVNLPRGHIWVEGDNYFHSIDSNTFGPISSGLVIGKAITIVWPPSRWGTDLKLSTGRDCISKRAILE
The following text describes a protein:
Function:
Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MRCFRASCCAPSPWQRACSTVASVSDTADLVIVRESPLDNVVLLEMNNGRANVLTPEFISAFLNKLSDLCDPDKSKCSGIILTSKNPGVFSAGLDLNELNTNLSQDRFAQYWSQFQKLFTTLHALPVPLVGAINGHAAAAGCIVALACDYRVMARRHPTKPTHLTIGIAAAKHGFVVPSYVAASMEHVVGFRKAEELLCMGLLLSAGEALKVGLVDEVVEHHDETVVPCLQFMEKLLELPSPAPYWMIKDLSRRHILAPLCTPALRTQDMVSFYNLFSNLQVKKMLAEHAQKFAKK
The following text describes a protein:
Function:
Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit B may play a regulatory role or be directly involved in electron transport.
Sequence:
MSNVYWPLYEVFVRGKQGLSHRHVGSLHAADERMALENARDAYTRRSEGCSIWVVKASEIVASQPEERGEFFDPAESKVYRHPTFYTIPDGIEHM
The following text describes a protein:
Function:
Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
Sequence:
MNALEEQNCPECQATVVNDMQNGELICSGCGVVVADQVADYGPETISSNLEDKMKLARATGQTTYSQHDLGITTEIAISTKDFSGKTINHEVANQMHNLRKWQQRVRVSSPKERRLANVLTKMGETCDGLGLSKNVLETASMIYRNLDGHVDVKGKSVVSITAATIYMACKQCDVVRSLEEIIRGICPPKDVKSKTKLAARYYRTMVMEMGQLTAPVVTMDKYISKIANMTQTEVRVERLALEIAEKTKDSSIADGKAPNGIAAAYLYVSSVLLGQNVLQRDVSSIAGVTEVTIRNRCKEILTNYKLKITLRPSLAKY