lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity. Directly binds some unknown ligand, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor.
Sequence:
MPVGSRQNRVQAVRKVSGSTDSTIPREAGIYPIRYTERKERKDVQTVENGTNEDSRASQSRGRRRRQPTSRTLRQTSQSRPEVLERNESGSDCKKGVHSHSSARKVEREGSRCASRGLHLSSTTRCTAXELDVAKQEEKEEEDNKEGYADEEQKIENSTQERKVVNTSMEDKATSHSTKGSFRLTNSDSNKELHKAIKVRGSLSKTDITEKAKFVNEVVEKEIISQVFKIDNRFTFDILHAGSYYERLKVGEADEFDIMVQLNAAKLSNIFQPRFCVARRHSRHLVGFAYLEYQSHFDGHKKWEDLLETGGPDSRPLLSPKLILEHFKELLSQRLHQINCVGKQPWRSYCEPSLHGPAVKLTFCLANDKTLDIDVVLCIQSQHWPPVANNWGVLNPLQWPGAQQVENIKKRGCHVVPKVNPRDQKCWRTSFSLAEKDLLSPKSIDEDKEHYKIVKVIFERHKASLEPLCSYHLKTLFLWLRSDGNWTEKRTQFKVIEYFIQQLLEKVRMKELPHFFIGHNLNLFSDLSDAQVTNITTCLKEIIKNK
The following text describes a protein:
Function:
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Miscellaneous:
MISCELLANEOUS: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
Domain:
The Walker A ATP-binding motif also binds Pi and PPi.
Sequence:
MPSISVRRLFDDNQYKLQLAWAAGNSGADNRIGVEADKPVLALVGHLNFIHPNQIQVVGLAESEYLNRLESGETGYQFGDLFDISMSLVIVANGLPVSPGLRDYCHKNDIPLLTSKLESPYLMDVLRIYLQRTLAASSVKHGVFLDVFEIGVLITGHSGLGKSELALELISRGHSLIADDAVELFRIGPETLEGRCSPMLRDFLEVRGLGILNIRHIFGETSIRPKKILQLIINLVEADDEYMKQLDRLSIRTETESILNVNVRSVTLPVAVGRNLAVLVEAAVRNYILQLRGKDSTREFLERHQTQLKENEQHNEDRPD
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
DSDPWQDLKYHEPSTAAIAAYPELHKYHAPFDLALGQSMVWSNNADAGQGQSFGLYSPYGAQPMHGRVLLPPAIAADEPVYVNAKQFNGILRRRLARAKAARDLRVSRNRKPYLHESRHLHALRRARGTGGRFLSTSSLAAGDQAPPLASTSLGGPEPTKGSASTPARLQPGQVRQDVFLSPLINMAGNGDGQARWASAAPRACCDLLKV
The following text describes a protein:
Function:
Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. Promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia.
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MARTCSGSFCIISEVPQEGRLTEHDFTTNVDVRNLKQINWGLLVPGIIGGTLVAVYAVATPFLTPALRKICLPFVPATSHQIENVLKMLRCRSGTLVDIGSGDGRIVIAAAKEGFRAVGYELNPWLVWYSRYCAWREGVHDAAKFYVSDLWKVSFSQYTNVVIFGVPQMMPQLEKKLQLELEDDARVIACRFPFPHWIPDHITGEGIDTVWAYDCRGRKKSCLKPLSNMHL
The following text describes a protein:
Function:
Required for formation and/or maintenance of proper nucleolar structure and function. Plays a dual role in the regulation of ribosomal DNA (rDNA) transcription. In the presence of high glucose, maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, is required for the repression of rDNA transcription, and this function may be independent of H2A.Z.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus, nucleolus.
Sequence:
MEPAGRGGKRCTALRPQRGLQGVSGFRRPPLLRKTGSALPPRPANPRVPEAQGAEVTGGRSDGRWVRGKMTTLVLDNGAYNAKIGYSHENVSVIPNCQFRSKTARLKTFTANQIDEIKDPSGLFYILPFQKGYLVNWDVQRQVWDYLFGKEMYQVDFLDTNIIITEPYFNFTSIQESMNEILFEEYQFQAVLRVNAGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINVGGKLLTNHLKEIISYRQLHVMDETHVINQVKEDVCYVSQDFYRDMDIAKLKGEENTVMIDYVLPDFSTIKKGFCKPREEMVLSGKYKSGEQILRLANERFAVPEILFNPSDIGIQEMGIPEAIVYSIQNLPEEMQPHFFKNIVLTGGNSLFPGFRDRVYSEVRCLTPTDYDVSVVLPENPITYAWEGGKLISENDDFEDMVVTREDYEENGHSVCEEKFDI
The following text describes a protein:
Function:
Gustatory and odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr21a and Gr63a together are sufficient for carbon dioxide detection and avoidance behavior. It is possible that the CO(2) receptors Gr63a and Gr21a activate the TRPC channels through Galpha49B and Plc21C. This innate olfactory avoidance behavior can be inhibited by inhibitory interactions of the odors such as 1-hexanol and 2,3-butanedione with Gr21a and Gr63a.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTFLDRTMSFWAVSRGLTPPSKVVPMLNPNQRQFLEDEVRYREKLKLMARGDAMEEVYVRKQETVDDPLELDKHDSFYQTTKSLLVLFQIMGVMPIHRNPPEKNLPRTGYSWGSKQVMWAIFIYSCQTTIVVLVLRERVKKFVTSPDKRFDEAIYNVIFISLLFTNFLLPVASWRHGPQVAIFKNMWTNYQYKFFKTTGSPIVFPNLYPLTWSLCVFSWLLSIAINLSQYFLQPDFRLWYTFAYYPIIAMLNCFCSLWYINCNAFGTASRALSDALQTTIRGEKPAQKLTEYRHLWVDLSHMMQQLGRAYSNMYGMYCLVIFFTTIIATYGSISEIIDHGATYKEVGLFVIVFYCMGLLYIICNEAHYASRKVGLDFQTKLLNINLTAVDAATQKEVEMLLVAINKNPPIMNLDGYANINRELITTNISFMATYLVVLLQFKITEQRRIGQQQA
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MFAFIDTIKKPPLGGRKSFMPIPEAKLVDDVVSYIAKPEFYSTVPAALKMQRLFYVQYSELAAKLETDLTAVLTRLEAAKNNLELVRRFIDNPDKEVHSLVQIAQGVFRWVSIPPVQKVTLQVGASLQMEFELSEAEEFIKKDITSLVKQQLQHEHDIDYLQDQVNTIEMNLAVLYKHEVEN
The following text describes a protein:
Function:
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MPRFHLPENLSVGQTVALPDNIVRHLNVLRVRPNENITLFDGKGKAHAARLTVLEKRRAEAEILHEDTTDNESPLNITLIQSISSGDRMDFTLQKSVELGVTAIQPVISERCIVRLDGERAAKRLARWQEIVISACEQSGRNTVPPVLPIIGYREALDKMPSESTKLIMSINRARKLGDIRQPSGAIVFMVGPEGGWTEQEEQQAFEAGFQAVTLGKRILRTETAPLAALAAMQTLWGDFA
The following text describes a protein:
Function:
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFEFLHQMSAPKLSTSILRYIFRYAQFIGVIFFCLHTRKDDKTVFIRNWLKWLNVTHRIITFTRFFWVYIASISIKTNRVLQVLHGMRLVLSIPNVAVILCYHIFRGPEIIDLINQFLRLFRQVSDLFKTKTPGFGGRRELILILLNLISFAHEQTYLWFTIRKGFSWRFLIDWWCDFYLVSATNIFIHINSIGYLSLGVLYSELNKYVYTNLRIQLQKLNTSGSKQKIRRVQNRLEKCISLYREIYHTSIMFHKLFVPLLFLALIYKVLLIALIGFNVAVEFYLNSFIFWILLGKHVLDLFLVTVSVEGAVNQFLNIGMQFGNVGDLSKFQTTLDTLFLHLRLGHFRVSILGLFDVTQMQYLQFLSALLSGLAFIAQYRMQVGNG
The following text describes a protein:
Function:
Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli.
Subcellular Localization:
Cell projection, cilium.
Sequence:
EGKTSEEVGGWPGSPGREPHPGTHGFPPGMGVSVRQVTPTHLCATPCPPAIPLMTKSSLQKLCKQHKLYITPALNDTLYLHYKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLHKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLVKNKNKNNEKAPQETASIIFIKYQVLLSFLSFLPSFPFSHFFPLCVFIWSI
The following text describes a protein:
Function:
Lipid raft-associated protein involved in the targeting of PMA1 from Golgi to the plasma membrane (Probable). May induce clustering of PMA1, which facilitates partition of PMA1 into lipid rafts after leaving the ER its and transport to the cell surface (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 937 molecules/cell in log phase SD medium.
Sequence:
MAEKILENKDPKLEAMTVDHEVSAPKPIPVDEPTLTRVARPLRHVRHIPVKSLVFHSKHGPITFSYENKIKLPISKNKLVVQVNYVGLNPVDMKIRNGYTKPIYGEAGIGREYSGVITHVGDNLTNRWNVGDDVYGIYYHPKLAIGALQSSLLIDPRVDPILMRPKNTLSPEKAAGSLFCLGTALNLLAQLKEKDQLNTESNVLINGGTSSVGMFAIQLLKRYYKVSKKLVVVTSGNGAAVLSEHFPDLKDEIIFINYLSCRGKSSKPLRRMLDTGKVVDYDDFNTLKETEDYTQGKFNVVLDFIGGYDILSHSSSLIHAKGAYITTVGDYVGNYKKDVFDSWDNPSANARKMFGSMLWSYDYSHFYFDPNIKIIPKKNDWIHECGKLLNEGVVDCVVDKVYSWKNFKEAFSYMATQRAQGKLIMKVEGF
The following text describes a protein:
Function:
Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum. Golgi apparatus. Mitochondrion.
Sequence:
MAAVSSASDTGDSRGRHPPERRLLILGGPRSGKTSSANTILGDNVFDGDTETTHSNVGQTEIYGRRVTVVDTPPWAIPSDPEDDEDADTTDNAGAESDSPTRPAQSLDSEGPCMGAILCPPGPHAILLVVSVTQPFTEIERRAAEEQLGALGGGTWRYSIVLFTSVDKLPKGVFIEEHIENTGEALQWLVERCGSRYHSFDNTRKETEDNTQVPELMEKVEEMITDNQGWYFEVNELILLEEEQARRALEEERMRMEEHARQREQMIGGPPRELRLLLLGWKGVGKSSVGNSILGRRYFESGQETELCLRRQALVCGRRVTIVDTPGWDWFSVRRTPKRIRQETQRGAALLRPGPHTLLLVLPVVSSLTARKRRTLLAHIETLFGDDACLHTMVLFSCGDWLGRTPIEEHILRGGRDLQRLLEYCGNYYHVMDSKTPGKDRSVSVLLDKIEEMIRENGDKAFLPIQTEWLSEESSYSSDNTEPEDDCRGCMLQ
The following text describes a protein:
Function:
Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
Sequence:
MANLQKYIEYSREVQQARENNQPIVALESTIISHGMPYPQNVEMATTVEQIIRNNGAIPATIAIIDGKIKIGLESEDLEILATSKDVAKVSRRDLAEVIAMKCVGATTVATTMICAAMAGIQFFVTGGIGGVHKGAEHTMDISADLEELSKTNVTVICAGAKSILDLPKTMEYLETKGVPVIGYQTNELPAFFTRESGVKLTSSVETPERLADIHLTKQQLNLEGGIVVANPIPYEHALSKAYIEAIINEAVVEAENQGIKGKDATPFLLGKIVEKTNGKSLAANIKLVENNAALGAKIAVAVNKLL
The following text describes a protein:
Function:
Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type IV membrane protein.
Sequence:
MATVRICVCGDDGTGKSSLITSLVKDVFVTNKIQSVLPQITIPPSIGTPENVTTTIVDTSAEPQERNTLRKEIRKSNVILLVYSDHYSYERVALFWMPYFRSLGVNVPVVLCANKSDTTTNANTAQVVEDEMLPVMAEFKEIDSCIRTSAREHHNVNEVFFLCQKAVTHPIAPLFDSKEGILKPACVAALNRIFYLNDKDQDGYLNDQEMQDFQVKCFEKPLAPTDLENIKISISRASPNSNMEKGVDQKGFIHLNKIFAEKGRHETIWIILRKYHYTDSLSLKDSFLHPKLDIPEFASAELSPAGYRFFVDLFLLFDKDNDGGLNDNELNALFAPTPGLPSHWLDSNFPASTVRNEAGHITLQGWLAQWSMTTFVSPATTLSYLAYLGFEPTPGKPSTTTALKITKPRKRRRRPVRTERNVVLCYVLGSSSSGKSSILDAFLNRPFDDLYRPTIKPRVAVNSVELPGGKQCYLILEELGELEPAILENQAKLDACDLLCYTYDSSDPDSFSHIIDLHKKYPALSSLPSICTALKADLDKTTQRCEKQPDEYAQLMNMNAPVHVSVTWHSISELFVTLAEAATDPSKAFPKSEEEAPDRTGVWIAVGATACAVVAAVG
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus.
Sequence:
MAEENGSAVVLQCNVLPMVVGLQRQHGLRHNDFQRYRRFCTRRIHRLRHTIKLTHGKRTFQPAPITAANLTSEAHLEILLLEIERAWAYALEDKQDAKDTPRKRMHARTRLGKAVKHAEALKALLAQAAEEQTATVEEATQTELQAYLTWIAGVAAFENSNWERATELLTQSAQIYQGLAATPAIAADAELQKIYQQRVTEITASLRYCHYNIAQTQGHGADASKALKDLKAQLAADDAGVMAMLGERLEAALVVEHEGDADSFANVTWLGRTAPVPTLPIRQTLAQIQGRRDEMTAANFADTKEHLVAFDQLLMDYAEAERVTAKALADERAEAGSNASESSLEKQAHLQFLKAYLAAERLRTTMERNYVMVDASAARLRADEGKPDELIRLYDDQLQVVTDLETIELIQDDADAMDAIAARQAYFRALRCFYVAEVLRRTDKFKESLRLYDRTQERCTQAHAAIKRLDEPLSEDQRVQADLAMVKRSIRAVHLTMKATVALTDAQASATKSAAATTALADDLQVFDDSEAALERPLVALPPQMQPIRCKPLVFDLAIDYRQYPSLAHRLETKATAASVTSTVGGVLKSFTGGWFS
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
Subcellular Localization:
Nucleus.
Sequence:
MDPLAGGEVNIGREWPTINAKDDEKEEEASTFVDKKILRMMKMMGYQSGFGLGKNKQGVTEPVAVEPHLSKRGLGLEIKNLDYSKEEWDYSLDKPTVVEKVSWLCSEKVLELSEDEMVKWPREGKPTNNMEEEFNFCDKQTLHDVLQGKNIFDVLDLKELCQARARANPFETIRSVFFMNRASLKMANIDAATDFMFTNINHSHHEDSGPYYFADVCAGPGGFTEYILWRKKWMFKGFGLTLRGDNDFKLTESLCASPVTFLPLYGASGDGNACSPENISDFSEKVLFETENKGVHFMMADGGFSVEGNENIQEILSKSLYICQCLIALEILRKHGHFVTKVFDIFTCFSVGLLYLIYHCFEKVCILKPNSSRPANSERYVICCNYKGRENVESIRIYLKKIVQRLWELKNDNNLDVIEIVPLSILKSDHNFYSYVCDSNNRIAKNQTISLQKLAAFCRNPLLTEYRQEELRRQCLDYWKIPDKPKIPLPKYTTENLLDETVENRELLLVQPREIYSIEQLQTVVDDLNDWHYALMQCKRATNICNFYAGVGLSRVYRMQGNKWVRVKNLQLVRGTLLYGELVKEKCYMEESVGKVGYKYSLHVIDALRLGDLYLTDLKFDERIKLIKIYCKAINYEFRTNSIRIRPKSIHDLQSLSLDLPLTKDQSSGTYFSPLPVLGYKVNNEGFEVNSLLLLKTGQHQSFHSTYVLRVQMFLEGDQHFSLDSLVELIRQKRALL
The following text describes a protein:
Function:
Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Also has I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MAVWVKKALKYRLLALGCLTLLAMATLKYSSTWNCDYTDLGVDTRHLGNEYCKDQLYRALKLPPQNRINCSQIIKGDRSALEEASLRSLEAKRVPLTETQYLHMTKDCSDFKNERRFIQFPLSKEEENFPIAYSMVIHQKIENFERLLRAIYAPQNVYCVHIDEKSPEPFKEAVRAITSCFPNVFVATKLVAVVYASWSRVQADLNCMEDLLRSPVPWKYLLNTCGTDFPIKTNAEMVRSLKVLNGKNSMESEVPSAYKRSRWKHRYMVAKNTLFQMKMEKGPPPDNVPMFTGNAYFVACRSFVQHLFENPRARKLIEWTNDTYSPDEHLWATLQRVPWMPGSIPHHSKYHTSDLNAIARLVKWMGHEGDVGKGAPYAPCTGTHQRAVCIYGAGDLHWMLQNHHLLANKFDPQVDDNALQCLEEYLRHKAVYGRAL
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEVTPHADLLLLQSRMKEDPGGYEAELDLQLRHFKACLGVLELEAPDTGNGSVSFAALAPDHAAAKELGDMAMFLAHVTPSYPKELAGFPHQLLNLLENASNRLPSSLRCHLAQALILLRNREKISLVEVLPVMIKLQSSGDKNLKKFVSSHLLQNISRMNRKHRNEAKNRSLQNIIFPVIQEDDEARAKHAFVLTCELYRRKVWIDPQTANAICNACFHKSPRIMIATLKFLHGYENKYDEDSDESDQEDDTPSGAVGVSKEAIYKSQHKGTVSSKKKKQAKIERAIRSLKKQQRIKAQEEKKGSFAPLEHLRDPQEFAEKLFARLQNCNEKFQVKLMMIMVISRCVGMHQLLLLSFYPHLQRYVSVPVDAVEPLLKQLVNSFVHDRSRPEIMTRDLLEDLSMYKKSREKAVSAAANSIIGLYRQVNPSLLMKKHRGRGTDLSVEPKAFGKVVVHTDVPGVELLAEQEEDENNSGECGDEDDESGREEEEESSEDEGEGSGEELEDDNEEKDEEDDEGEDDEDSGDDNEGSDEDVLETLEKELKNGETKQVATLKRKKMDGEESNLDDMSLSQLKKFAGSKLEDDEVSGDGILSNEDFRRIREIQAKREAENALSNHGLRKSLRTLHFFLSARSAHSVLLYLQANIRRKQSKEERIASSKAGRDDRGTYTSRAAVKKRKVCFSFARSLVRFCLFGFRLEA
The following text describes a protein:
Function:
Important for biofilm formation. Represses expression of McbA by binding to its promoter region, which prevents colanic acid overproduction and mucoidy.
Sequence:
MPGTGKMKHVSLTLQVENDLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVGKRQLDEINRIRYELELMAVALAVENLTPQDLAELQELLEKLQQAQEKGDMEQIINVNRLFRLAIYHRSNMPILCEMIEQLWVRMGPGLHYLYEAINPAELREHIENYHLLLAALKAKDKEGCRHCLAEIMQQNIAILYQQYNR
The following text describes a protein:
Function:
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
Sequence:
MQDINSGSSSMKDTYSSWIEISKRSLSNNLDNFRSILRPNSTLTAILKSNAYGHGIEPMTRLCIEAGISRIGVNSIEEALLIRNIDSKIPILIMGEIQNPEKRKDVLSDPNFWIVFSRPETARILSSFLPAPKLHLKIDTGMGRLGSHGETLKQTLSELKNVGITLGGICTHFASTEDVLEHKYSLMQTQKFEEAIFLAKSFGYNHLIRHACASASTMLFPNAHFDMVRIGISLYGLWPSIQTRLSLNLTGNKNFQLNPILSWKSRIVHIQYHPADSYIGYGSTFQTSYPTKVAIVPVGYYEGLDRKLSSNGDMLVLGKKARIIGRICMNMTMLDVTHIPGAEVGSIVTIIGQDGEESITADDLADRTHTINYEVMTRISESIPRIVVD
The following text describes a protein:
Function:
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of sordarial, a salicylic aldehyde structurally related to the phytotoxin pyriculol. The most interesting aspect of this pathway is formation of an aromatic product from the highly reducing polyketide synthase srdA. SrdA synthesizes a reduced polyketide chain from one molecule of acetyl-CoA and five molecules of malonyl-CoA. The polyketide chain is then reductively released as an aldehyde. The oxidoreductases srdC, srdD and srdE then oxidize one of the hydroxy groups to facilitate the intramolecular aldol condensation, followed by dehydration to yield a salicylic aldehyde. This aldehyde can undergo facile reduction by endogenous reductases to yield the alcohol 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene. The flavin-dependent srdI counteract against the propensity of the aldehydes to be reduced under physiological conditions and is responsible for reoxidizing 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene back to the salicylic aldehyde. This salicylic aldehyde is then selectively epoxidized by the cupin-domain-containing oxidoreductase srdB to yield the epoxide, which can be hydrolyzed stereoselectively by the hydrolase srdG to give the final product sordarial.
Sequence:
MTFKVIIVGGGPVGLYMAHAFERANIDYVILEQQDTVLNISGQLLFTWPQTVRLFDQIGLLADLENVALGIHHKKRLFGDNGQVTTTSNFWDAMQDNHGYPFLPLLRSELVKILYNHLKGRESNIRVNSRVTDIRPHATGVHVHLADGSLIQGSIVVGADGVHSRTRQIMDSLVAQHALNPARLANKPMVSTFYGIFGRASNVDLGIEPEVFFESRGGGGEGGAVVQCLATKDIVQFVTLKPLPGGPTSERSPRYSDEEMDAYAASLADVAVCPGVKFGDVWAKVQRKSTRMLNQEEGFLDNWFFDRIVLVGDAVHKSTSVNGLGMTCGLHSGAVLANELHSLLSRQREKEEEPSTEELEGAFGRYQEDRKTEVKPIWNGGHAMIREVVKKGWVSWFWDRFVLPWCDMETFAKGLLVSVLLIRQGQILRFVPFEGRGGRVPWARKVVV
The following text describes a protein:
Function:
Involved in copper homeostasis.
Sequence:
MSEQDIKFEVCVDSLSSCIEAINGGASRLELCSSLFSGGLTPSYGLMKTLKEYIENHEISIDIFVMIRPRSGDFLYNQDEITIMKHDIELVKQISNQCSSFSGIVIGLLNSDGTIDKCNTEKLVELASPLSVTFHRAFDMTRDYIESFNTLNSINCSTSNNNNNNNSGGGCGKISRILTSGMESSVLEGIDTIKELIKLSNGTDITILPGGGITQKNINKIIKKTKLKEYHISARTVSDSKMQFRNTSVFMGGSLRESEYTYAIVDKNKIQGFINKSNTN
The following text describes a protein:
Function:
Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKLKQRVVVLCAVLFLLGLAKVFLLDGGEGSAASRRDLRAFRKMEASLSLAKGARLTHTLQSPWEVAAQWVGPREVYPDETPELAAVLNALATAHVERADVGYKGTQLKALLVLDGGQKVVFKPKRYVRDYVVEGEPYAGYDRHNAEIAAFHLDRILGFRRAPLVVGRFMNLRTEIKPVATDQLLSTFLMHGNNTCFYGKCYYCRETEPACAEGDVMEGSVTLWLPDVWPLQKHRHPWGRTYREGKLARWEYDESYCEAVKKMPPYDAGPRLLDVIDTSIFDYLIGNADRHHYESFQDDGGASMLILLDNAKSFGNPSLDERSILAPLYQCCMVRVSTWNRLNLLKGGVLSSAMRQATAHDPAFPVLTGAHLTALDRRLNGVLATVRQCMETQGSENTLIEDRMNLPHP
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Has DNA primase activity. Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL).
Subcellular Localization:
Mitochondrion.
Sequence:
MYRLFNTRISSFRKLTNLSSGFNSENVNFKVRDGGGLLNTQLNNYCIACARNQSTNTNPNLAPKKIRKRSKSKKSYYDLLVVTETNAKQQKTSIKKLTWNDLKLLASTNLNLSELHKLKDLTKDNQHVQEHTYNNLAVIDPIAAEETPNEKERVVTITDIPQPPEQPQPPVEELLDTIPKIDFLQPEIIDEPPEISEVSDPAPKINLSKKARYEISVKTLGSYLEMCSTLQTPNRGLNALIFHNQRATRGKDLTFATMKSIKVYNAVLKGFAAKGETSRLEEVLAMVRKENVKLNLQSYIAILECYGRANFHDHYLKQIRIYAKEAVTNGFTFDRMLNEGTFLNDERAVVLATMQKFDPSYRPKYAEPIVQYDNELVNSLNHDSQLELPEEGRLIDETGLFTPGFMQSAVAKQLELEKTGQIVVKSIENRGKVSDEVTKYREIMNQHIRDWEETAAKAFNRDLSALAAQKSPLNPEIYMRSIPLKDFVTILVNEAKQIAEGSETYSPTVNQLYRDLGSKVYARYKILRKQKTGVLDKVQSIHSRYCQSYAHQHEELGVLPETVHHVNPRQQWQWFEYSMKGTGATLTMDHRTWSPSTLQTIGKFLYKIVMHDLKVDVNAMKANIKHKNNHPAFYTVFRTQGRVLKEEVKPHPVLARLFRASMPETLTFPANELPMFCPPVPWTCVDNGGYLIVPCEVVRLPPQATSQKQRLYQSEVQQLYPPLDALNQLAAVAWKVNTDVLDVILEVFNNGGSAKLDVPEPPTALARPQAITNDMDKAQKFKLFRQKLQYRRKKAEMYSLWCDCLYRLSLANHFRSDIFWLPHNMDFRGRVYPVPPHLNHLGSDLARSMLVFAESRPLGPDGLNWLKLHLINLTGLKKRDSITDRLAYADTIMDDILDSADSPLTGRQWWAESEEPWQTLACCIEIAKATRSGNPETYRSHFPVHQDGSCNGLQHYAALGRDSAGAYSVNLCPSEVPQDVYSAVVALVEQQRLVDAANGVEVAKALHGFVKRKVIKQTIMTTVYGVTKYGARLQIARQLKDIDDFPKDLVWAASSYLTGRTFDSLRSMFTSTREIQDWFTDCARLISMSGQHVEWVTPMGLPIVQPYIRYKNLGTSLVYKPYHMDEFEKPNVMKQKNAFPPNFIHSLDSSHMMLTSLFCERAGITFVSVHDCYWTHPSTVDIMNKICREQFVALHSLPILENLSMFLTEKYSFRNDDLIGDGSISDLTKTKLNKVLRKLPKTGDFDITQVLKSVYFFS
The following text describes a protein:
Function:
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
Subcellular Localization:
Nucleus.
Sequence:
MSSKKRSKVETDSDSDSGPDDRNVPQKKGKPDEKKTASASRDTNADGEERFMLAKKRYLTVREFKGRVMVDIREFYEDNNGDLKPGKKGICLQLDQWNALKGHIDDIDAAIRKH
The following text describes a protein:
Function:
Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLRPSAANRTIRARFKSRCNVTGERQHASSTLRSFLERWTSLASGIIPTLNHDSRSKKSGYYILYAILDFIVDNYSPVLESIHDEVEGIEDDVLSKPISKAQIERLYMLRRDLLRLRNAIGPLVEVCRRLEHDELAMVRATMQPLFRDVTDHVRNIQERIDSMREVLAFAFEASLLVGQAQETAVSKKLASWLAILAVPTAVAGIYGMNFKYIPELQLEYGYFIVLGLMALACLGLYWRFRRVGWL
The following text describes a protein:
Function:
Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs of the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with up to 2 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) and tri-methylguanosine diphosphate (m3(2,2,7)GDP) to m(7)GMP and m3(2,2,7)GMP, respectively. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by dcs-1 to m7GMP. Binds to m7GpppG and strongly to m7GDP.
Subcellular Localization:
Nucleus.
Sequence:
MDVSAADAGSVPSPCSDVSVLVAHGQLTSLKDFVVVEVLSQDPLNKSIALLGRFAGRPDDAVLLLARKPFDAGDLPGLAGPGLELQLDFVNDIYSKYVGQPLPHHSRITVDLIYPATAKHVQKHREQKRIMVTETPELYEQVVLPYIRAIPPARLQWVYNILEKKKEVERLIFEDPDPVNGFMLHPDLKWDQTSSDQLYCLALVARRDLACLRDLTQEHLPLLENLRDKGCQAIQRRYGVAPSCLRVFLHYQPSYYHLHVHFVHVALASPGAAAGKAVLLDDVIDCIKTCGSDVWRRRTLTYQLGEADELWRLLGGGAQQEQQQAEQ
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MEENQRSKDQQRIITLLLNEQFELRSSVINSEILEEDDLITDSLTKGEQIVSRMDKTIGSIASLFSGAHTTIDELNNKLEEATNNKVDNTIDSLKKDKMLLQNAIGSINQVGDMLKLANGIQERIGSVNTFDECVNLLQDCIKIYQFMNDRKEYQFYSAHEIDTKNHLQIVYDKTLVFYNDLFVEISKPESVSQILSKESYIGTEYLQMLKKAMPIIFEAGTLLRANAHDVFAVIFENRKEYLLEVIQSITLPVLTESDEVVEYTVGYTNGKNAFITTMKHVLSLFQNERIFQQDILQNDFDKFFVGTTDEPFTAFIDLYTSFVSTLQTLDTPFIVFPLLDILEVYENMKADFTNALKINEDPKNKSKGFIALEKGFNVLTSSFTFGSDKKEDDEEEDDLYVEDTTGDKRDSQTKRVDALFDTMYTNVKTLLIKFRDEVLIDSTLNKIFSWTESSIPVDGTVSQLAADTMHYLSKLEKYLPQLSSYISRMYREENKQNSNGTEDEGYVGMFVDVCIQNLCQMIEARASKEKSRLGKIFKINNYAFIMNVCMLDGFEKLFGSSLQKKIESDFTTKKENAIHEYKDSLQSIYETLNARPSKSEQIKKAFTSFNKDFQALHTVSSGYSVYNDQLKEELRSVLKEQILEPYTLFYNNYEKVKFTQNPTKYFLYTPQMVEQCIKLMFEAKTDVNGESKELTDYIPDFLQNVPHFVPKMSTITSLATPLQNLPQHLKNLSHKPVDIVKETPKVIKNPLKSTKKFIKNINPF