lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Sequence:
MRALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTADLHAILEQHRPEVVFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAARQTGVRKIVHTSSGGSIYGTPPEYPTPETAPTDPASPYAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAGVVAIFAQALLSGKPTRVFGDGTNTRDYVFVDDVVDAFVRVSADVGGGLRFNIGTGKETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLKRSCLDIGLAERVLGWRPQIELADGVRRTVEYFRHKHTD
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MPKKAALDELKWKEVKLPDHLDDFDGFMGLEEIEGVDIKYQPKGAMKEVIYELPEVHEKKDKKPEKRKKDQKEASEKKKKGKRTSPTIEMTSLGSKVTSKNYNEFSTLEEEDEHNSHGVDVSAWAHFSLSPEMLGSLSKAGFSKPMPIQSLVIPEASIGFDIIGKADTGSGKTLAFGIPILEHCLRNVDAKYVQALVVAPTRELAHQICQHFELIKPSPNIRVMSITGGLAVQKQQRLLNKHPHVVVATPGRLWSVINENNLTGNFKKIKCLVLDEADRLLQKSHFEELSKLLEILGNPMHTQRQTFIFSATFDEGLQQRLKKNMKGNITEKYNSPMENMLKEVRFFGKPKFLDANPQSAVASRVLEGLIECAPAEKDLYLYYLIMRYPGKTMVFANGIEDIKRITPFLNELKVPSYPLHAQLDQKKRLQSLEKFKNNPKGVLVCTDVAARGIDIPSVTHVIHYHVPHTADMYVHRSGRTARANEDGVSILMCGPKELSQLKRLCYRLKKKIETFINFPVDMSILDILKTRVVLAHKIVNLTRKDGRVGREEAWLKSMAQELGVESSDDEDPDLPKKSESSKNKKQIAHLRSELAPLLHEKIRTGFSGRYLTSGLVNMAEKLANEEVHDNIIGMDSISALEVLQKRKK
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Domain:
The MATH/TRAF domain binds to receptor cytoplasmic domains.
Sequence:
MLDFINLINNINNPTSPTKITPKVIPIKYEIKDILVDSDEEKYECDICTLELFIESEPKALQCKEGHLACRRCWERYLSTNKQCMTCKTPISSISELSRNRYLEKEYSNWLNDRLVFCPNSNENVFRLNMSGLPAINNSNQTLHQDLCNHGAMKFSELQNHYKACESRILQCNLCLIKFCSKDSDKHQNECSKVYSKCEFCNSNILRSSLSDHHKTHCTKYLIECPHCKIMIKRDTITKHINDDCEEIMITCSEYLCGKRFTRSKMQIHSLEHSVTKLMNQNEIIKKDNQNLDQEKKIEEIKLKLNNLLNNYIQLKNEIAVLKQNSFKEMVYSNKWIIPEYRSFNALYTHKKSKNSNDFQVGSHTFYIKIYPNGQAGKQGKFGVFLERKPRYGILLKYMFSFSLLPPEDSTATKVSLGPIHRVLILLLIDFEESRSLSCGTNVFTDSRKVLKDFLNEKGELEISFSITIQDEKIIPL
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MSKQTSRKGKKAWRKNIDLEDLNAGLDSARENERQFGSKNLEQAGDALFTVDTAGTSGDVETYHSKKKEKRLKSDEILARRSAVPGVIGKKTKKEKKMSKEQLDMLLKKAGRRDVDNKMTEAALQADSVLETPVYDAWDEAPAPVVPKKKTITASKVVKPRSEFQGFPQSMTKVKNAGSRVAYMPKSAKPENIMRATFANGDHREATSRTRSTVRPSTLDHKPLVFGATDKAIEVPHEGRSYNPSLEAWQALLKEELAKEEALEEERLQLEADQARVQHLMDTMEDHEDKQMDYSSEEEEEEASDEELEGGSVGLSINAPAKEKRKSMAKRRQMREHKEKERIRKQMKMEMKKIHEKMQQLAKRSEKSEQEKQDLKDLIAGGEAAEKVRTRRYGKYEILEPTLDVKLSGELTDSLRRLKPEGSLMRDRFRSLQQRGKIEARKRHNLKPRYKKKVTEKWSFKDFK
The following text describes a protein:
Function:
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys; Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion. In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (By similarity). In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Subcellular Localization:
Cytoplasm. Cytoplasmic granule. Note=Localized in azurophil granules of neutrophils.
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
The following text describes a protein:
Function:
Golgi membrane protein involved in vesicular trafficking.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MFESIIVDRAKTTFLGELKSYNFSIYAQWLGILSIFLCIILGIVNLFHVTLVVLFSALTIIEGVLLIFIELPFLSRICPVSDKFQAFTNAFASNYYRGLVYFIFSVVTFLSCIFMATSLIATGIVLALTGLCYTFAGIKGQAFTSSSTLGGTGITTETPPSTMV
The following text describes a protein:
Function:
GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.
Sequence:
MDGSISSLPTQTTPTPLGLPPSESSRPDRPKLLFMGPRSGGKSSIREVVFHKLQPDQTLHLETTRRITQDDIKSFIDFEIWDLPGPLDSDVLTLPFAHVGAVIFVIDAQSSYLSTIPQLASTVIQAYQTNPALHFEIFMHKIDAVTPDYRSEIIEQVKDRLTDELSDRELSIYGVPTIAIELSHRITYKLTTVFDYSIYDALSRVIMKIVPQQAALEHLMNLLAQQSGVENCILFDTWTKLYIATDSSPTEKPLLEMCTEFMDIFTDLSELYGVPQQISPVTRPTSMTNGLGKNAPMVSTRQVPDSSHTKRSLSRGRASVLSPATRSSSVAVDQNKKPASLAGKRMITSQVKVDTSFGGPRGIGMPGIEQPGRVISYYEINQFLTLVCITHEEIMRTQGTLIEYNVSRVRESIEKIFQITNGTPSKHRRRVS
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MFSVKRFDAFSASSPSGSKDDPADTAKLDALNERILKKRKLVQGNEASGSNLPGTSTSSASSNAASTAVPAPSVARPALNIHPSRLNVAPLLRQSVKKAQTGPREKTKAKQRYLKAKKERRKARIRAAPKKSKADNDGSQARADNSIGLHLPEEEALHRREAARKKKTQHSPVAQKADSDSSSPSSSDSDSDSDSNSDRHSDQESSSDSEQDDVESASPSTPKASTLETETLSADVEMDVDVGAQKEDKALERFPLAGVRRAVDPKLIRSLGLPEGLSNRTVVDPTLSRPLWQQKELNKPANPAKASSPPPLDGGALVDQEMEEASPDDQESVTISARSSASDDFSKVALSDIVRSRLEALGISEWFAVQVSVIPCLLAQPQSRSLYRPFAPPRDLCVSAPTGSGKTLAYSVPIVEVLRTRQIVRLRALIVLPTRDLVSQVRSTLELVAKGSGLRIGTATGQHSFAHEQNQLVGSSSAVDQDQDEAQSEPKIDILIATPGRLIDHLDSTPGFNLAHLRFLVVDEADRLLNQSFQEWLRRVLAATNGKTDQAERERASQKSGPAQAPFELFSSSASGLGAAATSTLQEEAAPSVQKLLFSATLTRDPAKIAALGLRNPHYITVQDTNSAGDEDQGRANGVQQHEQFSLPHSLHEHMLVTTSADKPFHLLYLLHRPDDVNNELGRIRKALCFTKSVDSAARLVKLLEIFEEVRVENSLIARGSRALVVKNYSSELKPSDRQRILSAFEKGEIDLLVCSDLISRGIDLPSVEHVISYDAPIDPAKYVHRVGRTARAGKHGDAWTLVEEQEARHFKKTVRTIARRTPIAKIRPKKLRENETVDFVEGDAVTRELHKLRGAYEDALARMSTLYRN
The following text describes a protein:
Function:
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
Sequence:
MMGVLSIQIGQCGNQVGYEFFDILHKYISCSKNEYFKSKLTTMYFDEEYKYGKNLLPIVEYEENEGNRNYMNVNNNIMCLNNLIARCILIDMEPKVIERCLSLNNNYDDCIKRKVQKKEKYQKIVKCNSEKSVGKKKYDDSDECCLQYVCGLDDYYESKNNFLKIFKRNNNNNNNNDHHHDNDGEEYNIYAKSKHNNNNNNNNINNILFKKSLYNNNILFKKSLYNNNDILKDDKLNGNNNLYNSYKNADHEENNNLVKTNFCSSSYFTNEWKFNKSNFICGLNGSGNNWAYGFYVHGKNICEDFINIINKEFEKNESKESIDNILLFHSLAGGSGSGLSSYISYILKDEYPKTNIFNICILPYMFGEISVQSLNTILCLCSLYDCSDGLILIENDKFELMCKRINNDENINLEEINKYISLFIAYNIGFPIDLSNSNYNNNCNYCNIMNYIVSDLCCHPNYKLLSTRYLPQVFKENIIFEQNSFNMLIKRMHRMLIKGTILDSNNICTNVMKKITNDISCNYIDNYYINRLSSRNILKNKNIFYKQNSFHIPIHMNEINSNSYIDQHDNSVYLKKKKKKKNYYNCIQKTSKNQNNQDNILYQHKNNYHKTDEYNHYTHNNVILNSKMIMRGEINENIDLHLFKNHVLYNNKSLNPLEIYIDQNKQFTNNSISMISNCLTPIPTLTHILEKAKLLYSTNAYIYQYNNYGVTHDQIYNSLMYVEQIINSYESLSSE
The following text describes a protein:
Function:
Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
Subcellular Localization:
Secreted. Bacterial flagellum.
Sequence:
MGSSIASSLMDPTQYYSQFISLQKASLEKAKTPYQNQISSYQSRIDLYASLKNALSESLKTMSSFTTYESKTKLATSSNETSFTVSSTSSSVNGSYSIEVQNLATADTYNKAVPDIEAKIGVSGTIKINGKEIKVDADSSMKNVMNSINSAGAKVNIYTLGENMVVTSSTTGVENSIKFEGDSAVLDALGLVQNSPDHLAAEDAKLRINGATVTSATNKVTNYIPGVTINLKKETTGAEKLTIQDQSDEKAASMITSFVNTYNALTSTMKTYTGKGTILQASAADLEANRALNNVFQHKKDGNTLFDFGISVDKEGVLKVDETAMKKMVAEDPTAVERFFFGIGGIGDELYQSLNKTFGSTGFISDETTSMTNEINKLNLKLTDITSRNDTLLTNITDQYNKWLEMMQAMQSDAMTLDALIDGMNSSNK
The following text describes a protein:
Function:
Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex.
Sequence:
MTEKTTKYYSLQVVSQERIYNFLTKISVFASDKIAQDFIHSIIDQICGRIVSFDRFINEENERIVNQLIRVYSLFINRVVGRDLKKEYICEDLKTANVDGLYINVIADCIISRFTDIKRELTEKLSTISSSSLSDFDWKMNAILSSDRINIVQENVLLLNLTIETNHNDKKEQVLIELTKKELDHILEVFDQINDVIQSLKV
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
Subcellular Localization:
Cytoplasm.
Domain:
The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.
Sequence:
MASSTKKDYYEILGVPRNASQEEIKKAYRRLVRKYHPDICKKPECEEKFKEINEAYQVLSDPEKRKLYDMYGHAAFEGAGAQQRVETTEIPPIEEILREFFDFDIGSIFERATGRRRARRRRSVKGEDIVVPVEITLEEAFKGTTVPIEVEREVPCSACGGTGYDESKSRTCPTCGGRGETVQGNWFFQVRQTCPTCGGEGVIYENCHACTGRGYGLVKETIKVKIPPGVRDGSKLVVEGKGHAGRYGGPPGDLYIIVKVKPHKIFERKGDDLYVDVNITYPEAVLGTEVEVPTLDGEKVKVKIPPGTKEGELIKVPGKGMPRLKGSGRGDLYVRVHIDVPKIGVLSKLLGDGKKVEELLKQLQEVLPKPERIVER
The following text describes a protein:
Function:
Chromatin-associated protein which contributes to the modulation of chromatin structure (such as super-helical structure of DNA) and function (By similarity). Binds to chromatin of protein-coding genes throughout the genome to regulate nucleosome occupancy and chromatin accessibility, and to modulate the expression of target genes (By similarity).
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Note=Associates with chromatin (By similarity). Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei (By similarity).
Sequence:
MGEEDTKVIVEPTANGTSSLQKTSDAISGKEVQENASGKEVQESKKEEDTGLEKMEIDDEGKQHEGESETGDKEVEVTEEEKKDVGEDKEQPEADKMDEDTDDKNLKADDGVSGVATEEDAVMKESVESADNKDAENPEGEQEKESKEEKLEGGKANGNEEGDTEEKLVGGDKGDDVDEAEKVENVDEDDKEEALKEKNEAELAEEEETNKGEEVKEANKEDDVEADTKVAEPEVEDKKTESKDENEDKEEEKEDEKEESMDDKEDEKEESNDDDKEDEKEESNDDKEDKKEDIKKSNKRGKGKTEKTRGKTKSDEEKKDIEPKTPFFSDRPVRERKSVERLVAVVDKDSSREFHVEKGKGTPLKDIPNVAYKVSRKKSDEVFKQLHTILFGGKRVKATQLKAHILRFSGYKWQGDEEKAKLKVKEKFEKINKEKLLEFCDLFDISVAKATTKKEDIVTKLVEFLEKPHATTDVLVNEKEKGVKRKRTPKKSSPAAGSSSSKRSAKSQKKTEEATRTNKKSVAHSDDESEEEKEDDEEEEKEQEVEEEEEENENGIPDKSEDEAPQLSESEENVESEEESEEETKKKKRGSRTSSDKKESAGKSRSKKTAVPTKSSPPKKATQKRSAGKRKKSDDDSDTSPKASSKRKKTEKPAKEQAAAPLKSVSKEKPVIGKRGGKGKDKNKEPSDEELKTAIIDILKGVDFNTATFTDILKRLDAKFNISLASKKSSIKRMIQDELTKLADEAEDEEGEEEDAEHEEEEEKEKAKGSGGGEEVKA
The following text describes a protein:
Function:
Stimulates specifically the GTPase activity of ypt1. Functions on the Golgi as a negative regulator of ypt1 (By similarity).
Subcellular Localization:
Golgi apparatus, Golgi stack. Cytoplasm. Nucleus.
Sequence:
MESQSKKSSALKTLSSLWNGSSSATSDPVTVLDRSRTHHHRGRSTSSKAQPFRLDDSVYSDQPPKDHISLARSITRPESASESKIYAPSARSSLSLEAVVGKKVSAKFAKYLSQTDDDWGVSNIKASKSLPRMARSTTPNSSSRSLFPQNGVDTTTSRQKLHSSGRFPLPAKLAHRSVEVEVAESNALVSRIKKFSRILDAPIVDLNALRTLAWNGIPSEHRPIVWKYLLGYLPCNASRREVTLKRKRDEYNAAKDSCFNTNTEPPPLDQTIWRQIVLDVPRTNPSILLYQNPLTQRMLERILYVWASRHPASGYVQGISDLVTPFIQVFLSEYIGDKDPMTYDIALLDETNRNDIEADAYWCLSKLLDGIQDNYIHAQPGIRRQVNNLRELTLRIDEPLVKHLQMEGVDFLQFSFRWMNCLLMRELSISNIIRMWDTYMAEGVQGFSEFHLYVCAAFLVKWSSELQKMEFQDILIFLQSIPTKDWSTKDIEILLSEAFLWKSLYSGAGAHLKR
The following text describes a protein:
Function:
U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MSDVDMESGSDDSGMEDLDEEIQKIKQKMIDDSQSVVLANQLLILLRKNGDFDELDIKRRQFVEWAPLNPLNWKNWIEDFQNRKPEPSVAEVEEMFEKALFDENDVTIWVERAMYAYKVANDKNKKEDFKFCRDVCSKALENLGTRYDSGGHIWLIFLEYEMSYLKNSMNAPDYQRLADQVFALFERALHCPTDQLEDVYVLAEQFCTEFKQHHKLEELKKTYNSTMRQKEQLSKFEELIQQEETKKQGLKQFFDHEKKSGIPSRIKMAHERLVSELDDDEEAWIAYGAWADIELKLPQVAVKVYSRALRHCPYSFVLHQQALLAFERDRRPNEEIDALWERARSNVINSAEEGRSLYRTYAFLLRRRIHLTGSSDYSPMAEVFDEGAALLREWFSMAWDTTADYRQMQAYFYASLMKNMDKCRNIWNDILASGFGRFAGKWIEAVRLERQFGDKENARKYLNKALNSVSDNINEIYMYYVQFEREEGTLAELDLVLEKVNSQVAHRAIRPQKKVSEKPAPAPKSKQDHIQKRTSGGEPIVKKVKGDDGGFKAPLPPSNAKSSSAVSSSNASSTPAPGSFAVQKAAPGTEDARTIFVSNLDFTTTEDEIRQAIEGVASIRFARKANSDLVHRGFAYVVMENDQKAQQALLKDRVPVKGRPMFISANDPEKRVGFKFSTTLEKSKVFVRNVHFQATDDELKALFSKFGTVTSVRRVTHKDGKPKGIAFVDFDTEASAQKCVASGDKLMLRERELEVALSNPPVKKDKSHGKPAAIGASLEEDGPRKGHAAKLQLVPRAITNKTPQITARLDAMDVSEGTSTSQPLSNDQFRKMFMKN
The following text describes a protein:
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MDAIDSVIDPLRDFAKKLFHEASTMDAIDSVIDPLRDFAKDSARLVKRCHKPDRKEFTKVATRTAIGFVVMGFVGFFVKLIFIPINNIIAAWRLRNAKKYK
The following text describes a protein:
Function:
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSLRAEDAGAGTEGSKPGAGSGETPAAEQLEEAVERLQRENRRLREQAPRAAALCGLYHEAVQQLSFLQGQLASRDALVARLRASLAAYESSGPGLGPGPAPSLVDGLVEQVGRLKEQLREQESSARSREDRLGQEVQKLNQQLEEKESELQRLLREPQHERDREILLLQRSLAEKAKAQATSEVLCRSLTDETHQLRRTLAATAEMCQHLVKCLDEKQRSGGHGEEKPALERSNKLQFPEGDISVHAIICKLQEENRLLKQKVVHVEDLNAKWQKYDASRDEYVKGLHLQLKELKVLPEQGLPTSPEIMQKEIFRLNKLLEEKMADCLKVKRELEDIKKAKDGDSERIQMLEQQVLVYKDDFTSERADRERAQSKIQELKEKVATLQHQISRRQESRETTGHCRIHTSHKNHTQHLETDVAEALLRVEPQGTRRPILQPEQPEIATDRRISGSDLRGQGQGDLHCPHCMRFFRDEEGEEFLRHVSECCQ
The following text describes a protein:
Function:
Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.
Sequence:
MATTMAKLITLVVLAILAFVEVSVSGYKTSISTITIEDNGRCTKSIPPICFPDGRP
The following text describes a protein:
Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfonates cholesterol. Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA). Conjugates efficiently cholesterol but has a greater affinity for pregnenolone sulfation. Does not show high activity with DHEA. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (By similarity); [Isoform 2]: Prefers pregnenolone over DHEA as a substrate and does not sulfate cholesterol.
Subcellular Localization:
Cytoplasm, cytosol. Microsome. Nucleus.
Sequence:
MDGPQPPALWGSLENRVSELSQKLQGEYFRYKGIPFPVGMYTPESLSLAENTSNVRDDDIFIVTYPKSGTNWMIEIICLILKDGDPSWIRSEPIWQRAPWCETTISAFSLPERPSPRLMCSHLPIELFTKAAFSSKAKVIYLGRNPRDVVVSLYYYSKIAVQLKDPGTPEQFLQNFLKGEVQFGSWFDHIKGWIRMRGRENFLFITYEELQQDLRGSVQLICEFLGRPLGEEALSSVVAHSAFAAMKANNMSNYTLLPASLLDHRQGAFLRKGISGDWKNHFTVAQSETFDQVYREQMHGLPSFPWDRSAEDGSPDGETEPSPSPSPGLASDDPNPGSSQ
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MCSSEDIVDCFHSDTLLCCLNEQRMQGALCDVTIVVEDTKFKAHRNILAASSLYFRKQFLNQGILIQGHVLELTDFKADTFTEILNYIYSSKIAVKRKGALRDIADAGKKLGIAFLENIKNANSSCKRSSLPTAVSSSQTEKRLPPILYRDDNSMKSETLEKKADDLAIANGPRITNAFSILETEVCGFSPLDLRANFKKTTGYTQEMNGRDQCENGVCNDSEPVNTLAEHSYAVSSGDLLYKRDSRTEERSMPFIVPTMQEALPASSMPVLEPQCVIPQTTIQSCNSSNVKSMNCPGVKDQESTSDFYKDNKNGVAQLPSNNSPANQSFHDPSLLYPLPKKHQEIFNCKNCSKEFAHLKRLQRHEQICFKMVPTDKDTKTTDSLSGDTTLEKSSSSLDQISDQNSLPNIITPGSDHFVKIVDGKIFYVCIVCKRNYVTLSSLRRHSNVHSWRKSYPCHYCNKVFALAEYRTKHEIWHTGDRRYQCIFCLETFMTYYILKNHQKSSHGIDPRMGVVNKTANRGLKPSIYPYKLYRLLPMKNKRMSMKTPGNDTPANTGIHFQGHSSFNAATIVQNSLESQTFNLESHENLPCTSDIPQNISSSNINQNTWPFEVSQSENINTLPEKKDNSPLHNASSAPKGCNALVSSSGNATQCVPSVINCTSSAPSVIMHSSRTSSVIMHGNSVTATSSTNGVNWYHEKTIVSPKRDSSSQDTSKGVADSQSMKEISSEDSQARDVQQEELDLFSPVPSKKSKSVIKHGNKTETYIAKPALPGTLVNSGIAPLCKITVKIGSEALVNRQISGSSLFFRKSVRPKHSKSRADKSNQNSEEEGKERSSSRLRKSDSAKMEEMCDDLSDQDVSDKPWRPYYNYKPKKKSKHFKKFRKLKKRRKHSNKRSDVENQEEADIKDISRTVIEESEDGKEENLQTAEYTENSAAEDIDVSDWQLATKPCFCELCQKSFRNPSTLKVHMRCHTGEKPYTCKICGKCFSFPGNLNKHERIHMGVKNFMCQYCSKSFMLNETLKKHERIHTGEKLYGCQFCPQQFLNVCTKNNHEQKHQTERSVKGFVCIQCSKICKTAAALGMHQKKHYLRSLKRKERKEIAAAESWGASTSTPCKTMDITKTSGVTNVPESVVVPFEGKETPLLSFNGGIGDRSPQNVGNTHIDEGLAPEELPESRLETASAMPPVAEYGTVLMEVPKGWKHWKTRHYSLEEGMNSDNSSTRECTKTFTELKTMTSFDPFVP
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
MAKFSFDDADDDPPAAASGGEKRKREDGPAEAAGGWEPPKPRILVARGGKPEGSAVVGAGTAEGSGRNAVETVVGGEADGISVRIDPDVLDCSICFEPLQPPLYQCQNGHVACFSCWSRLTNKCHICSYDANFARNIALEKVVESVKSSCSYAKWGCRKLVSYSLRHAHEESCLFAPSICPIPGCGYKGFTGWWSGHFLTNHNTDGSLRFSYGQWFEVSLEMSVPFLVLLAEDDHLFLLVNKNVLPFGHALSVGCLRTGNLNWNFTYEMRAASKANTENNLQLKACVTNIREWQGLHPTEAFLLVPYAFCKSNKLTLNVCIQRSADLRVNM
The following text describes a protein:
Function:
Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine. Substrates include proteins required for pilus biogenesis PilE, PilV, PilW, and PilX as well as some components of the type II general secretory apparatus GspG, GspH, GspI and GspJ.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPLLDYLASHPLAFVLCTILLGLLVGSFLNVVVHRLPKMMERNWKAEAREALGLEPEPKQATYNLVLPNSACPRCGHEIRPWENIPLVSYLALGGKCSSCKAAIGKRYPLVELATALLSGYVAWHFGFTWQAGAMLLLTWGLLAMSLIDADHQLLPDVLVLPLLWLGLIANHFGLFASLDDALFGAVFGYLSLWSVFWLFKLVTGKEGMGYGDFKLLAMLGAWGGWQILPLTILLSSLVGAILGVIMLRLRNAESGTPIPFGPYLAIAGWIALLWGDQITRTYLQFAGFK
The following text describes a protein:
Function:
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MTTILSKLSRFAPKPTNTKNFPQGFKVIGVHCGIKKKEKLDLGLLLSEREETSGAGCFTRNRFKAAPVKYSINKLLETQGHKIAGVVINSGCANAVTGTRGDSDAAEIARLVDEHLHKNGSASSLVLSTGVIGQLLPTERIHAGVIEGLKRLGDNYESWHALAEAFMTTDTFPKLLTHSFQLDGQEIRFAGIDKGAGMITLRWAHLMLPYSALSPPTPPSDRTRSNEHSPRQSIADQKRLEIFEHELASFALRLAKLVVRDGEGATKFVQVLVRGAQNEADATTIATTIATSSLVKCALNGEDANWGRILCALGYSPISHPIDTQKVSVSIRTADDLQQILLLSNGEPVPDIDELKAKEILKNEDLIIDLDLGHPIDHQASFYTCDLSKEYVAINADYRS
The following text describes a protein:
Function:
Glucosyltransferase involved in the last step of benzoxazinoid glucoside biosynthesis. Catalyzes the glucosylation of hydroxamic acids utilizing UDP-glucose as glucose doner, reducing the toxicity of these natural insecticides for storage. Can use DIMBOA and DIBOA as substrates, HMBOA (2-hydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one) and HBOA (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one) with a lower efficiency, but not indole acetic acid or quercitin.
Sequence:
MAGAGRRRVVFFPFPFLGHFNPVLRLAGALHARGLAVTVLHTEQRVPDPADYPADYRFVSLPVEVPPELAASEDIARMGMAMNDAAEAPFRDRLAALLAEEEAEDGGVLCVITDVVWYSAQAVARELGVPALGIMTASAAIFRVYMAYQTLIDKAYLPVQDARKDDPVEELPPYLVKDLLRHDTSKLEDFAELLRHTVAGARQSSGLIINTLGAIEAANLERIREDLSVPVFAVAPLHKLAPSAKSSSLGETQADRGCLGWLDTQEPGSVLYVSFGSLAAMDPHEFVELAWGLALSKRPFVWVVRPKLIRGFESGELPDGLGEELRGRGVIVSWAPQEEVLAHPAVGAFFTHSGWNSTVEAIAEGVPMICHPLHGDQYGNARYVADVWRVGVEVDGSHRLERGSIKAAIGRMMESGEGREIGERMKALKMAAEDGIGERGSSHTHLSDLVALIKSF
The following text describes a protein:
Function:
May play a role in the regulation of cytokinesis.
Sequence:
MLHRDGKFYHSRNARAVILLSRNILASGISQAQITAFESGWATHVLRLVQSYGDEPKGANVIPLAYQALCNLCSGNQGVSAEMFKTYFVPQKGDKKEDDTVTIVWDKVLLDTALYAFVVTLCECINDDVELLKQFDNAEAPASELLDVLIAPVTFDSAIHARPEYQALVDVFRYLAANRVTGRLSPSYQYPVIVAIVKDAITVDLEVVIETEAKSTPLDLEHLFIAYFSISMKELKLVLDTESKSCNAAQVIRFCFEALTVLLATEPKLPTCSGQLQHDYPEFITQVTNYLVFAQKEYPAKRKLKEIQTSVLEVTDYPHVKSATIELLSSILQIASATSKQQLAMVQSLIWKAGGLPEILNCCNIDANNPFLKERGVVCLRYVMEGNEEAQKFVADLEAQSQAQKLDPKNEESLP
The following text describes a protein:
Function:
Oligoxyloglucan-reducing end-specific xyloglucanase involved in degradation of xyloglucans. Releases the first two glycosyl segments from oligoxyloglucans. Active against cotton xyloglucan, tamarind xyloglucan and tamarind xyloglucan oligomers (Probable).
Subcellular Localization:
Secreted.
Sequence:
MRAKNGPGSWLALTAIATSLNTLALAAAKTINHSYEFNPVVVSGGGYITGIIAHPTEKNLLYARTDIGGTYRWNADEDKWIPLNDFISGADENLLGTESVALDPNDPDRLYLAQGRYLNSENSAFFVSQDRGATFDVYPAPFKMGANELGRNNGERLAVNPFKTDELWMGTRDAGLMVSEDGAQTWRNVSGFPQANANGIGIYWVIFDPRSEGTVYVGVGVPGGIYVTRDSGESWEAVPGQPVEWDEDILVFPAESQPQSTGPQPMKGVLAENGALYVTYADAPGPYGVTYGGVYVYNTTSSAWTNITPKTNNSFPAPFDNQTFPAGGFCGISVDSKNPERLVVVSLDRDPGPALDSMYLSHDGGKSWKDVSQLSTPSGSGGYWGHPIEEAAFKDGTAVPWLSFNWGPQWGGYGAPSPVRGLTKFGWWMTAVVIDPSDSDHVLYGTGATIWATDNLSKVDKNQSPGWYIQAQGIEESVALALASPNGGDSHLLTGLGDINGYRYGDLDVPQPMFDLPVLSNLNALDWAGQKPEIIIRAGPCGHNYTDGCGLAAYSADGGSSWTKFATCIPGINTSSSNPGVIAIDASGKDIVWSSAMTAYWPTLQAITPRTNQSGPYVTTDLGQTWVSPTGLNVQTPNISADRVQPRTFYSFTDGTWYLSRDGGLSYRAYKAKEVGLPAYSGALPIANFNRAGEIWLGLGDHGIYHTRNFGKKWTKITGRGVTARQLTIGAGARRSSEPTLFIVGKAASHGALSKDGVYRSDDNGKTWVRVNDEKHQYGGIAMIQGDPRVYGRVYLGTGGRGIIYADIKE