lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex. Plays a role in the assembly and maturation of clathrin-coated vesicles. Recruits FCHSD2 to clathrin-coated pits. Involved in endocytosis of activated EGFR, and probably also other growth factor receptors. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones. Inhibits ARHGAP31 activity toward RAC1; Plays a role in synaptic vesicle endocytosis in brain neurons.
Subcellular Localization:
Cell membrane. Cell projection, lamellipodium. Membrane, clathrin-coated pit. Nucleus envelope. Recycling endosome. Synapse, synaptosome.
Sequence:
MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTAVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQEAQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLLTLKRALEAKELARQQLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHSKQQLQKQKSIEAERLKQKEQERKTIELEKQKEEAQRRAQERDKQWIEHVQQDDEHQRPRKIHDEEKLRREESVKKKDSEEKSKLDTQDKMSRLFHQHQEPAKPAVQAPWSTTEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPGPDLTSAPAPKLAVRETPAPVAVSAPEPSTTPNSWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGWCFLFWVFNFACFHTMKSDTAEVVTIHSIHNLFPVSVT
The following text describes a protein:
Function:
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MKTELTLLEQTLTLHRFPKRNNETLQAWDAGDEYLIQHVEQLALPESSHIVIINDHFGTLSCWFSQKHKVSMMSDSYIAHQATQANLQQNQRPPVQLLTTLDPVPNDASVVLLQLPKSNRHLVWILSQLRKALSPNIPIIAVNKAKEIHTSTLNLFEKHLGPTTTSLAWKKHRLVFSSATVNPANEVNPECGWSIEPYAITLTNLPNVYSGESLDLGSRFILEHLPADPTLEDFIDLGCGNGVLSVRLGQLNPQAKITCVDESFMAIASAQKNLHDNLGKRDIHCIANNCLDGFPAHSSSMIVCNPPFHQQQTITDHIAWQMFCDSKHVLKKGGKLWVIGNRHLGYDVKLARLFGKSHVRVIANNSKFVILQAIKS
The following text describes a protein:
Function:
Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8-dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis, a major pterin in E.coli.
Sequence:
MAQPAAIIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTVTKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTLSWQR
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MNSQANDSDSEYSVENEGLESSAEEDKGSDSNDTSDEDADEDDEDEDVPKLADDEYKTMPFEDLLKLQKKLGARMYNEAIFGTSKDKKPNALKPKPSKKAKQKSASENESSSDSDSGPEEMTSKRKVPALGMGKKDKNASLTQPRDPRFDPRQGYFSGRQFRNNYSFLNDLRQKELKKLNNKLEAATDPEEASKIKFLIQRTENQIREYAKHKALDADRMREKQQARAAIQEGKRPFFERKSTKQARALVEQYDKLKDHGALDKHIDKRRKKISAKDRNKLDFAT
The following text describes a protein:
Function:
ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
Domain:
Consists of three main regions, an N-terminal coiled-coil domain that binds to protein Pup and functions as a docking station, an interdomain involved in ARC hexamerization, and a C-terminal ATPase domain of the AAA type.
Sequence:
MAAHDDDMNRGIRPGRGSEDPAGQVAYLEQEIAVLRRKLAESPRHTRILEERIVELQTNLAGVSAQNERLAGTLREARDQIVALKEEVDRLAQPPAGFGVFLQANEDGTADIFTGGRKLRVNVSPSVELDELRRGQEVMLNEALNVVEAMEYESVGDIVTLKEILEDGERALVLGHTDEERVVRLAEPLRGLTIRPGDALLLEPRSGYVYEVVPKSEVEELVLEEVPDIGYEQIGGLGGQIEMIRDAVELPYLYPDLFREHELRPPKGVLLYGPPGCGKTLIAKAVANSLAKKVAEVTGQAAGKSFFLNIKGPELLNKYVGETERQIRLVFQRAREKASEGTPVIVFFDEMESLFRTRGSGVSSDVENTIVPQLLAEIDGVEGLQNVVVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAAKDIFGKYLTERLPLHSDDLAEHEKDKSATVSSMIQTAVEQMYAESEENRFLEVTYANGDKEVLYFKDFNSGAMIENIVGRAKKMAIKDFLDKNQKGLRVSHLLQACVDEFKENEDLPNTTNPDDWARISGKKGERIVYIRTLVTGKQGADTGRSIDTVANTGQYL
The following text describes a protein:
Function:
Probable minus end-directed motor protein with a microtubule-enhanced ATPase activity. Binds ATP/ADP in vitro. Retains total enzymatic activity even after the removal of the ADP bound in the active site.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MATRPASRQRRASSAAAAVAVVRSSPQPQQQQQQQLPIPQSGSPTSTTTTTTSSSRLTPELSLDGPASPLFAGLDEDPAPKENVTVTVRFRPLSPREIRQGEEVAWYADGDTVVRSEQNPSVAYAYDRVFAPTTTTRQVYDVAAQHVVSGAMEGVNGTIFAYGVTSSGKTHTMHGDQRSPGIIPLAVKDAFSIIQETPNREFLLRVSYLEIYNEVVNDLLNPAGQNLRIREDPQGTFVEGIKEEVVLSPAHALSLIAAGEEHRHVGSTNFNLLSSRSHTIFTLTVESSPCGESNEGEAVTFSQLNLIDLAGSESSRAETTGVRRKEGSYINKSLLTLGTVISKLTDGKATHIPFRDSKLTRLLQSSLSGQGRVSLICTVTPASSNSEETHNTLKFAHRAKRIEVQASQNKIIDEKSLIKKYQNEIRRLKEELEQLKMGIITGTPVKDAGEDNIILWKQKLEDGNVKLQSRLEQEEEAKAALLARIQRLTKLILVSTKATQTSRFSPHPGPRRRHSFGEEELAYLPYKRRDIVLDNESNELLSPVEGLGMTLEDSKEEKKNRKGILNWFKLRKREGGASILTSSEGDKSSLTKSTAPSTPIGESVNFPSEPRISNSLVGESASVDLFSIGHGEFATDSLHGEETPLASRKTIDHVDLLREQLKILSGEVALHTSVLKRLTEEAGRSPNNEKIQMEMKKVNDEIKGKKHQIASLERQIPHSISNNQGMADKLELTPSYAELLEQLNEKSFDLEVKAADNRVIQDQLNEKTTECMELQEEVAHLKEQLYQTLQAKDSLSNSIMMQKNAGINHETDNHADQELSVPREVPGETSPKEPQSVEIDELKQKVCELIEVKAQLETRNQKLLEESTYAKGLASAAGVELKALSEEVTKLMNQNEKLASELASVRSPTPRRANSGLRGTRRDSISRRHEPAPRRDNNAGYEREKALEAVLMEKEQKEAELQRRIEESKQKEAFLESELANMWVLVAKLKKSQGHDLEDFDTKYIGS
The following text describes a protein:
Function:
Catalyzes the transfer of a malonyl group from malonyl-CoA to the 6'''-hydroxyl group of the 5-glucosyl moiety of anthocyanins. Active towards bisdemalonylsalvianin (pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside) and shisonin, but not towards nodemalonylsalvianin, salvianin, pelargonidin 3,5-diglucoside and delphinidin 3,5-diglucoside.
Sequence:
MTTTTTILETCHIPPPPAANDLSIPLSFFDIKWLHYHPVRRLLFYHHPSSKSQFLHTIVPHLKQSLSLALTHYLPVAGNLLYPSNTEKFPQLRYAAGDSVPVTIAESNSDFESLTGNHTRDADQFYDLLPPIPPIEEESDWKLINIFAVQITLFPGEGICIGFSNHHCLGDARSIVGFISAWGEINGIGGYEGFLSNHSDSLSLPIFDRSFINDPNKIDAIFWKVLRNIPLKTASFPLPTNRVRSTFLLRRSDIEKLKTATKSPASSFVAAAAFVWSCMVKSGDKSDENAPELFIIPADARGRVDPPIPENYFGNCIVSSVAQVERGKLAAEDGFAVAAEAIGGEIEGKLKNRDEILRGAENWMSDIFKCFGMSVLGVSGSPKFDLLKADFGWGKARKLEVLSIDGENHSMSLCSSSDFNGGLEVGLSLPRERMAAFEEVFRASIMAASGPARRSPALVEPL
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MADTLLDVDGIETCYGLSQVLFGLSLSIKPGEMVSLMGRNGMGKTTTIRSIMGLTPARAGSIRFAGSEVRTQPSYRIAKLGVGLVPEGRQIFPNLTVRENLVAAAADRFGSSNPWTLAAIYVMFPRLAERASNMGNQLSGGEQQMLAIGRALMTNPKLLILDEATEGLAPLIREEIWNCLSLLKSRGQSILVVDKNVDHLARICDRHFIIERGKTVWSGTSDELMAEPDLQHKYLGI
The following text describes a protein:
Function:
Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Subcellular Localization:
Nucleus.
Sequence:
MSFKELLIEIGPENLLPEKLLPSLLQIKPNEIDQGIALILAEILIPGSQGLSQGLTFASSLPGSNAKGAQLQTCFKSIENSGKFNVNWYEVFNHVHQYLFDSSQRDIQPSVGSITQFLSSLDFKQEPIDIFLNYEWWFNKTLLYILHSSDASQGGYDISLSPNLAYCFEEDKTTPQTRRNILKFINVGKLEIQVITKIQQQQQQQQQQQQQQHQLSEQDKKLNAFLNQLFEHDYRVFPEYILAAALTVVEKSQFINDLIDTLFYLLVDSASPSLPKVVRLLKESGLAAIKLADYYKSRKTIDAADKVLTLASSFGLTQEILDIFWAFDSKIAIKILVESSLFGYDYKSVIDSKLKDPQVKTSIYQALCEALDERAQKDYERGQQVQQAQQLQQQQALPPHQVLKIPTVYYLLEKIKSSNGVVDAKTLRNLQLLLLTTYPRLINFGNGHDEAILANEEKSPFFPPSVEMEMKAYYSKMYNKELEIKEIVDMLTQMKASDDLHSQDVFACMIHSLLDEYKFFSEYPLSALASTSLLFGALLEKDLIQGTTLTVALNFIWESCNQPQDSHLFKFAVQSLYNFKSRLHEYPIYCKHLLECRSLSAHAKMYQIVKDAANGIPCTTGAAPTQTNTPDVGPKYQSINYVDRTIGYATQEEPPESIRDKLLFSVNNMTGENLRLSEIQEVLTESYFAWFSDYLVSDRAKAEPNNHELYSKLVKSLANPIFFEYILNVSLKEVDYIIRNFKDSRSERNQLKNLGAWLGRITLANDKPLRRDYIALKFLLVEAYDFNSLPLILPFVCKILDQAQYSKVFKPPNPWVVGVMKVLAELYECADLKLQLKFEIEVLLNSFNMKIKDIEQSTIIRNHNPEPTALARMFGISSQSVNLANEMTRLSLEGSQLGNNIQAPFPQQIIESKQFPGISQPQMQNVLQQQQQQQQQQQQQQLPPQQQLPGQLPPQQQAEPALDTSFSTLIGNSIFTQHANLRRAFQASLSRAVRECTPHICNKVVETVVTTTKALITKDFATERDIEKFRNSYQKLALSLSHAMVSCNGRKALVETIEATMLQLLGNNPNEVPLAELNSAIQANVGLCVDIVDVLVGESILDIIEARMQTEVFLREHHTATAPNEPFIAEGASDYSLRLPNPLGLALTGLSAQQLKIYEHFGEARVDQIVPPPGSTGITQQQTQSLAPLQQQQQQQQQQQPVSTVVAAAPAPAPPQQQQQSKERIAQAQGVPDDIVSFEQLFTAITANCDKAVQLVSEVTETKLADLPPNHSIMAALTQALVIAQTNAIKYPELLLKAAQYAVNCLFTQTHENPMSNEIYVVILDKLCEYSPSTAKDVIWWLVHSSDQRKFNMPVMLSLLKVQLIQPIKLDLSIGKLIKETNNPVVVKFAASLLTNIFTSEEMRPIALRSEFANTLDALSKYQANDQSEEDRQAKEATSTLFKLLSEAAPASNQLFAQLGYIFAEWVRLLTHGDDATNELQIEFVKGLIQSGILNNPEYVKTFFKAAIEISITSFATEHELRSRTQHETYFAVDTLAMLIVRIVLLVEDSKQAIDYLKKVLGIIILNLINDHETSKANWNERAYFRFFSSLLSTWCDASVLDEEVTVNLDVEFYNYLGELFNALQPIVLPGFTFAWISLISHRMYLPKLLELPERKGYATLVKLLSSALKFQQIYGNNKQSSRRQQELEQEQEQEQKDEKDAKDAKEQNQEQEQEQENSQQGPEVINVTYKAINRIFIGILHDFPEFLVECHYQLVTSIPRGYIQLRNIVLSATPKDIHVPDPFTQGLKVERLPEINESPVVFYKPIEDLSKVGLKKPVENFLRIPAPGLMRTIYNGLKLNQPKEVNELGYEETINFNIKLINALVLHVGISSVADRLPNNRGFNTKSSQVALLVDLMNYGNTEFKYHLINAIANQLRYPNSHTHWFIGIILHFFSNNNIWNSNGNKLVVQEIITRVLLERRISNKPHPWGLTILFTELVKNGDYGFFELPFVKDSVEEVKNIFNVLSINVKGSTP
The following text describes a protein:
Function:
Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
Subcellular Localization:
Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MEGPRRPQGGAGTRWRPERSCRAAADGDPPNPGRTGSGAAMWTLLPRGRQKLFHTVLDLSPFQYLHLSAHPVKKAYPDFSSSVQNRKDTEPALENIFSSEQQYAILQVLNTASAEELAEFRLLRGRKSVNIVEHREKHGPFVDLQNLLDVPLFQYKTTVQVCNSILLPSENEKEEKKRQASVTLGRLIRPEIERARLKTAKSVVSVVFGLHKLAWAHLDHKLTVLDWQQEECSRLMRGDYVPSVYLEEVSSIISMMPEADFYVLEKNRLSVQQASLFPLTLHFHIMEAMLHALLNKTFMQDGQHRVLSLNRVAVGKHFGLMVGSSRTSGKDLVKQMLTCSVTEANPRVSFLPENVVHYQQMFSPVAQTRDEEMYDSLLQAVAFYELAVFKAYS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-glycero-alpha-D-manno-heptose 7-phosphate at the C-1 position to form D-glycero-alpha-D-manno-heptose 1,7-bisphosphate (By similarity). Exhibits ATPase activity in vitro.
Sequence:
MAILRGRAPLRLGLGGGGTDVEPYSSQFGGRILSVTIDKYAYAFAERGTGDEIAFRSPDRDRAGQASIDDLASLEEDFPLHVAVYRRVIAEFNGGTPFPLQLATQVDAPPGSGLGSSSALVVAMLLTTCALIGSSPGPYELARLAWEIERVDLGMAGGWQDHYAAAFGGFNFMESRPNGEVVVNPLRIRREVIAELEASLLLYFGGVSRLSSEVIADQQRNVVERDADALAATHSICAEALEMKDLLVVGDIPGFADSLLRGWQAKKRTSTRISNPAIEHAYQVAQSSGMVAGKVSGAGGGGFLMMIVDPRRRIEVARSLERECGGSVAPCLFTKGGAVTWHIPESTAPVRRGVADAVASALGNAGILLCAGCVLATSHSTWRVPV
The following text describes a protein:
Function:
May transport inorganic phosphate (Pi).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKFGKEFIAQMIPEWQQAYVDYSCLKSILQEIKNAQKRSGAVTRKQPVHRNFSGLMTKHSSRVATSEELENQDIVVSEMIGDDGFDRYETSIMRVAEAGREPELVFFKTLDLEFDKVNHFYKSKVEEMVKEALVLNKQMDALIAFRIKVDQPSSSWICSETVSVNVNALGTTEHIKTLADVMGIIVSNHGDSTRGNVPEALSVLERIRLNKDQETPLSRIRNVLKLSSHEELKFTRENLKKIEERLKDVFIKFYRKLRHLNNYSFLNTLAISKIMKKYDKIASRNAAKTYRETVVDKSYLTSSDEIRKLMVRVESIFVEYFASSNRSKAMNLLRPKVKKEKHRTTFSSGFFVGCSVSLVIALALLIHARNIMGADGKNIYMETMFPLYSLFGFVVLHMIMYASNIYFWKRYRVNYPFIFGFKEGTELGYRHVLLLSFGLNTLALAAVIMNLDMEMDPNTNDYKTITELLPLFIVGLVILITICPFNIFYRSSRFFFIMVVFRCIAAPLYKLKKKITAAASAFTSVFGKKEIQQQGPVNLPDFFLADQFTSQVQALRSLEFYICYYGWGDFRLRQNTCRSSHVYSTFYFIVAVIPYWSRFLQCVRRLVEEKDSTEGYNALKYFLTIVAVCLRTAYSLNRGNSWRNAAWFFSALATLYGTYWDIVFDWGLLHRSSKSWLRDKLLVPHKSVYYVAMVVNVVLRLAWLQTVLDFNIPFLHREIMVALLAILEIIRRGIWNFFRLENEHLNNVGKFRAFKSVPLPFNYDEE
The following text describes a protein:
Function:
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
Subcellular Localization:
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Sequence:
MEDFVRQCFNPMIVELAEKTMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIIVELGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRKLADQSLPPNFSSLENFRAYVDGFEPNGYIEGKLSQMSKEVNARIEPFLKTTPRPLRLPNGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPKTKNMKKTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPELRSLASWIQNEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTSEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLIRSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEESSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALS
The following text describes a protein:
Function:
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
Miscellaneous:
MISCELLANEOUS: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTVHPPVVGHCDELQVALGAFRASAHVTQRWGDRLAAVLGGGGRLLAAGNGGSAAQAQHLTAELVGRYRDDRPPFSAIALHADTSSTTAIANDYGVDEVFARQVRAHGRKGDVLMLLSTSGASANLLSAADAARAAGVRVWALTGRAPNPLMAGSDESLCVEAPSTATVQEIHLVAVHMICAAFDAALERGEHGARAAGSAASTGRAARRERAASTGRAAGAGRAAQRKRR
The following text describes a protein:
Function:
Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes.
Subcellular Localization:
Nucleus.
Sequence:
MIRGFEAPMAENPPPPPPPVIFCHDSPKRVLVSVIRTTPIKPTCGGGGEPEPPPPLIPTSPGFSDFMVYPWRWGENAHNVTLSPGAAGAAASAALPAAAAAEHSGLRGRGAPPPAASASAAASGGEDEEEASSPDSGHLKDGIRRGRPRADTVRDLINEGEHSSSRIRCNICNRVFPREKSLQAHKRTHTGERPYLCDYPDCGKAFVQSGQLKTHQRLHTGEKPFVCSENGCLSRFTHANRHCPKHPYARLKREEPTDTLSKHQAADNKAAAEWLARYWEMREQRTPTLKGKLVQKADQEQQDPLEYLQSDEEDDEKRGAQRRLQEQRERLHGALALIELANLTGAPLRQ
The following text describes a protein:
Function:
SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.
Sequence:
MRFIHTSDWHIGRQLHNQSLLDDQAYVLDQIVALAQQHSVDAVIIAGDIYDRSIPPGSAVALLNDVLNRLVNQLGIQVLMIAGNHDGHERLGFAAKQMAASGLHIIGPLQAELVPIRLTSPSGDAYFYPLPYAEPTTVRQVFETDAKGLSVSSHEEAMALLLEQVRSHDSQGLPKVVVSHCFLDGGSESESERPLSIGGADKITPRLFSEFDYVALGHLHGPQYKGCEQVRYSGSILKYSFSEQHQHKSVTLVDIAAQFPAQIQLLPLTALRDLRMIEGELANLLEEGRTDAKREDYLMVRLLDKHAILDAMGKLRSVYPNVLHLERTGLMAGDQAVVLNRDHIKKGEMAMFRDFFAQVSGDELTPAQQAVMEDILTQLHRDGLERSETHRDVKEEQAE
The following text describes a protein:
Function:
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport (By similarity). Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (By similarity). Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth (By similarity). Required for skeletal homeostasis (By similarity); [Osteostatin]: Potent inhibitor of osteoclastic bone resorption.
Subcellular Localization:
Secreted. Cytoplasm. Nucleus.
Sequence:
MMFTKLFQQWSFAVFLLSYSVPSYGRSVEGISRRLKRAVSEHQLLHDKGKSIQDLRRRIFLQNLIEGVNTAEIRATSEVSPNPKPATNTKNYPVRFGSEDEGRYLTQETNKSQTYKEQPLKVSGKKKKAKPGKRKEQEKKKRRARSAWLNSGMYGSNVTESPVLDNSVTTHNHILR
The following text describes a protein:
Function:
Plays an important role in the biosynthesis of the phospholipid phosphatidylcholine. Catalyzes the formation of CDP-choline.
Sequence:
MKMGETGVATAEHNNQHHCANDLPPSDRPVRVYADGIYDLFHFGHARSLEQAKKSFPNTYLLVGCCSDEMTHKYKGRTVMTEEERYESLRHCKWVDEVIPDAPWVISQEFLDNHHIDYVAHDALPYADASGAGKDVYEFVKAVGRFKETKRTDGISTSDVIMRIIKDYNKYVMRNLDRGYSRKELGVSYVKEKRLRVNMRLMKLQEKVKEHQEKVGEKIQTVAKTAGMHHNEWIENADRWVAGFLQMFEESCYKMGTAIRDRIQERSRGQKSRDLLENGNTIDTDEEEDDEYYYVEEEEEEYFDNEEQHNEDKKNSSSSTE
The following text describes a protein:
Function:
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity). Expression of the complex plus RibU in de-energized E.coli allows riboflavin uptake.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MIEIKNLKFKYNQDQTSYTLNDVSFHVKHGEWLSIVGHNGSGKSTTARLIGGLLVADSGQIIVDGQELTEETVWDIRDKIGMVFQNPDNQFVGATVEDDVAFGLENKGLPYKEMVSRVQEALSFVGMMDFKDREPARLSGGQKQRVAIAGIIAMRPSILILDEATSMLDPEGRQELIQYIEDIRQQYGMTVLSITHDLDEVAMSNRVLVLKQGKVESISSPRELFSRGSELVDLGLDIPFSALLTQKLKNQGLIDCEGYLTEKELVEQLWEYLSKM
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MMESDEHNQESERNVTVENLNIEILPIIYEIIRSVEKDHHDNTAKARESQDCSQKVLELQKRLDQARAEIRLLPGIEYSKEQQLDHLEALKTQLKLKQELLRKYRYILSESYPMRKAAQVVVRAVYHGKNLIEERGLDKRLSPEEFRALMKRIAQNLQGQIKQASDEFKHKMK
The following text describes a protein:
Function:
Protein transport. Probably involved in vesicular traffic from ER to Golgi.
Subcellular Localization:
Membrane; Lipid-anchor.
Sequence:
MDRMADFLLLKIILVGDALVGKTCILQRYVDHSFDHSYVSTIGIDFKVKTLHVNGRFIKLQIWDTAGQERFHTISTRYFRGAHGLLIIYDITNVQSFDNVVGWTKDVDTNAGENVDRIILGNKCDLEDKRVVSKEKGQQLAWEHGMKFLETSAKENINIEKAFSILVEDILKKNHSNSQRLDVVNLKKSEKKRCCNR
The following text describes a protein:
Function:
Part of the ABC transporter complex YtfQRT-YjfF involved in galactofuranose transport (Probable). Probably responsible for the translocation of the substrate across the membrane (Probable).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MMPQSLPDTTTPKRRFRWPTGMPQLVALLLVLLVDSLVAPHFWQVVLQDGRLFGSPIDILNRAAPVALLAIGMTLVIATGGIDLSVGAVMAIAGATTAAMTVAGFSLPIVLLSALGTGILAGLWNGILVAILKIQPFVATLILMVAGRGVAQLITAGQIVTFNSPDLSWFGSGSLLFLPTPVIIAVLTLILFWLLTRKTALGMFIEAVGINIRAAKNAGVNTRIIVMLTYVLSGLCAAIAGIIVAADIRGADANNAGLWLELDAILAVVIGGGSLMGGRFNLLLSVVGALIIQGMNTGILLSGFPPEMNQVVKAVVVLCVLIVQSQRFISLIKGVRSRDKT
The following text describes a protein:
Function:
Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.
Subcellular Localization:
Cytoplasm.
Sequence:
MNDRQKEYFRLKLLAWKDEILKESKLTLQALQEENVNHPDLADRASSETDRAIELRARDRQRKLIAKIDAALQRIEDNTYGYCEDTGEPISLKRLEARPIATLSVEAQERHEKREKVYRDE
The following text describes a protein:
Function:
Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
Subcellular Localization:
Secreted.
Sequence:
MDWPHSLLFLLAISIFLAPSHPRNTKGKRKGQGRPSPLAPGPHQVPLDLVSRVKPYARMEEYERNLGEMVAQLRNSSEPAKKKCEVNLQLWLSNKRSLSPWGYSINHDPSRIPADLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPQPPRPGPCRQRVVMETIAVGCTCIF
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MRPVATSILHRAKWRPDPSLKLQNGDIHSGLVSLETISHKELFQQNLFDKAKSSPQKASSAESSEDSNAFQSFPEDELNVMADHSYKQEFVDEICSLADVEGIDEWVRLGLHPVLCKYLVRAGYTKPRAIQTQTIRAALHNKSLVIAAETGSGKTLAYLLPALHKAFTLVTNALKRPDQAQRRALQTLIIAPTRELATQINTVMTTIFGDIQKCFRIMYTIVGGISPQKQERFIRERPLILVGTPGRLYDISRSNAFFADTSLIDRLVIDESDKMLQKGRFHELIDLCSSLTSTVVDGCTAKVTISSATMSLPSLLRERNIKFSEPDEETGQPSNQGRTWKEKKWGSRKDNKFDRAIRSSKKALVLEIADNASVTESQRQIYMSWLKVLSNLGFSGSKLVIVDISPDCIVNKAVFELWNHVFDEAEKSVLMAYLVIRYRYPTIIFVKTIDQAKNFTTIFQLLGISAWCVHASMPQRQRYKNVDRLRDRDDTVLITTDVCARGLDIPHVSLVIQHSAPDSTSSHIHRVGRAARVESGADQKHVGMAVSLISPADNSRFVQIASVCGYTQKTMPPAIDIQSDILKSIKHIWLAASKAADALVENQSFMRRQSYKRRDEKNFNSSSDESDGDFREFTNNPEAQAVSQELSEQIKISRARLESLLSKPLKPLSKLRRPPMHLVGAATKVKEDVADLLTEHPRELKLGGSSGISLDRSEKRAVSSKVSSQDIPKKTSGVVSNVARTNKSTKGSNSRRAIKL
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MGDRVEALAIFRKKQGVLSIDSRLKWTGEGKTTPSVDIAFDAISNLQTTPASNPKVMIRVFIVVKEGEDPTSLVFHFTGTPNARENCDMITNELRNAIQRQREGSQSKPQGANVDRVNSTNLEKDIDLQESLLTNNPDLLQTFKEAVMKGHLSNEQFWSTRLHLLRAHAVERSQQRGPYNVLSTIKPKTVDNQMKVSLTGQQIHDMFEQHPLLRKVYDKHVPPLAEGEFWSRFFLSKLCKKLRGDRITPMDPSDDIMDKYLKDNEEVTKVSDEPIASHLFDLEGNDQNANVIAELRPDITMRIDKEALPFMKNINQLSERLLEKSLGNSKRFNNENEETYLKESGFHDLEEEASDSKVVLKIKGQDQLLENNFVPSKNQVGLEPLPSLEALQHLYQEDSISLNHIEHDSDSLAEAAMQLTQSMREKHEFETHGTASNLPIDIKNEIVLCHTVTIEFLHQFWNALLNTTFPDKKAMAPLQNALLNSKKRVEAIASQAQEQNVDPKLVYELVSCTLTSIDTSISEYQRRMSYPPA
The following text describes a protein:
Function:
Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).
Sequence:
MVFVTSRLTTLQSITLSALRRSESAPAGTMLTKRAFKTGSTAPDPPAPGVVRLISNRFCPYAHRTRLVLAAKGIDYETVNVCLAKRPEWFFSINPLAKVPTLQHDGKVVYESLVCNEYVDRVFPGRKLLPEEPLEKARIGMLQAIWDAKSGPNFMKVTMTKGEERQKAFEVLKEGLSFFEKHLGTSEAPFFGGEQPGFLDYSIWPWFELLGLFLTDDDVKLQEAEFPRVFAWQAAMFDRPEVKTCACELSVWTKYVASARAGNPDSDIGLDDSD
The following text describes a protein:
Function:
Inhibitor of PPP1CA.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MADSGTAGGAALAAPAPGPGSGGPGPRVYFQSPPGAAGEGPGGADDEGPVRRQGKVTVKYDRKELRKRLNLEEWILEQLTRLYDCQEEEIPELEIDVDQLLDMESDDARAARVKELLVDCYKPTEAFISGLLDKIRGMQKRTVAPKGQSLPPNLVATAIPGDPAARPGAMSRAPRAPGPGVSSPAPSVFHFWGFLLLLN