lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
Sequence:
MAISRTPPALGGGCLRILTPLLLLASIATLDAAYTPAPPACGKPQQLNRVVGGEDSADAEWPWVVSIQKNGTHHCAGSLLTSRWVVTAAHCFKGNMNKPLQFSVLLGAWQLGNPGSRSQEVGVAWVQPHPVYSWKEGSRADIALVRLEHPIQFSERILPICLPDSSVHLPPNTDCWIAGWGSVQDGVPLHHPQTLQKLKVPIIDSEICSRLYWQGAGQGAITEDMLCAGYLEGERDACLGDSGGPLMCQVDGTWLLAGIISWGEGCAERNRPGVYISLTAHRSWVQKTVQGVQLRGRSQGSGLAGRRGRAPRALRAPRAVQGRLG
The following text describes a protein:
Function:
Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
Sequence:
MLTTPPLAPKTVAALHRLGIRTLEELRQNGSVKAFLLLKASGLTLTKSTLWQLESLLDGTPPQEMSQAHKARLLAELKNHPPVAAFPPQEEMEHFMCEALRQAEQSSADGEIPVGAVIVSDGKIIASAHNTCIADCNVSRHAEINALAQAGREIQNYRLDGCDIYITLEPCAMCASALIQARIRRVIYGAAEPKTGAAGSIVNLFADKRLNTHTAIRGGILQEECRAVLSRFFQNKRKG
The following text describes a protein:
Function:
Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane. Plays an important role in osteoclast differentiation and function. Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity).
Subcellular Localization:
[Isoform A]: Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein; [Isoform B1]: Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein; [Isoform B2]: Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV
The following text describes a protein:
Function:
Probable polyketide synthase.
Miscellaneous:
MISCELLANEOUS: Encoded by one of the numerous copies of polyketide synthase genes and clustered as a pair pks24/pks25 in chromosome 4.
Domain:
Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).
Sequence:
MKQNKINKAEILQVDDKHVEENLVAIVGVGFRLPSGSIENERNNTPQTLWNNLINGFDGVVKTSERFNDNFFKNHEIANNYSGLLPLDEVKSFDPLFFGINPNEAPTIDPIQRLLLKCTWEALEDSLIDPISIKGTDTSVFIGCTESDYHNINKNEVKSNVFSSLNHAISNRISYCYDLHGNSITLDTACSSSLNAIALGYDSIKNKKSKMSIVGGVNILLDSYFFKAYSSLNILSKSNGRCKSFDASADGYVRSECIGVVVLKNLKDAIKDGNRIYCTINGASANVDGIGYSDKSNFYSPSSISQSENLKNAIQSTNGTVKPSDIDYVEAHGTGTPTGDPIEVEGISKVFKDTRSTDTPLLIGSFKSNIGHCEAASGIASLIKCCLMYKNKCFAPNIHFKTPNPAIKFKEWNLKVVTEPIPFNKFKNTSMVVNNFGATGSNCCLVLSQFNYNTINNNINNHNNNHNHNHNHNNIKINNYLIPFSANSVESLKKYQSLIIENKEYESQYSFEEFVKNQIYNKSTSLYQRSVIVAKDWNDFNNVENQVKYQTSSSTSSNITITNKNNNPITVFVFCGQGSQYNTMALELYKNEKVFRNSMDMLDNKMKNYFGYSILEKLRAIQDSDKCSVHEQTMAQPSTVIIQVSLYELYKHWGIKASFMLGHSLGEVTTAYCSGMIDIDQLCYLIYHRSTLQIRTNGSGKMLSINISSDEYKTNYMSRYPTIEIACYNSPSSIVIAGNEQILNEISKELKEKEIFSAMLGSLSSFHTSSQNIIKDDILNLNIQSSQPVIPTFSTVTSNLFNESTIFDSEYFFDNISKPVSFTQTISNLYKHIEDNQIGSNIVFIEIAPHPTLSFYLKQMIPKQSQYFRNGESISVYSTLHKKKNDVEEFQKSISQLFCDDAYDINFKCQFNNINSNIEAISNFNLPLYQWDDQHYWLNKSIEHKNNLIGPPISILGNSMQDSNPFIKSYQTIIDTGKDAFKYLKGHNVSDKCYFPGTGYIDNIFKLYPNQDLTINSIEFKVPFVLTDGIGQCLQTNVYQTGKSEYRAQFHLKDEMNNQWINTSNSNFHLNSNDNYHEEKQKLDIQDIKQTKCNLSSIPWDEFYSLMKTQLGANFYGIFSKVVECYIGDNCSLTEISLELPENFHDEQSFFNCPLIDACFHGTVILYIQKNCKIVTDKVEGLRYYASNIPKNRDEHSSIFIYSTLKSSPSDDLLSSSIVVMLEDGTVIIEVDNLVVKSLTPVKDPLLIETPSDFIYTPYLQSKDSQIQSPLEFKSIYQNNQVDDGLLIPNVVIETIKPLINRKMEFRILEFGGNNLSKSTLLLNEINSLLEENPHYEIDIEYTWSDNNSSILKDAKLELSKVDKGYLSILYRSLGLDVDNSLLEKQKLNPSYYDLIIVSNISNLTKDIEYSLNQIYQILTPNGYLIINEQQQQQQQQQQQQQQQQQQQQQLLNNENNKESLKNLLVNCNFNSDIMIKSSSISDSDIKSIIIQAQKPSLKLQPKTINTFDQVILYCYQDEQLQQQQLINKFENHYNNCKIIKVSTIEEFYKLSTTITNNSIIYFIKSIEQLTLENFKSVTFEYVQINQKLYELKSKCTHVLITCDSQSSNYLSSSVLGAARYFDEIPTLQLFTLDFDKDSLTNDLDLFKTIDYLINPKNNIQREFYIKNSGTVYFEMYKKELKNLKNSYKSESYHDLSKQQDQLVSKLDEHFEYQLNSKQIDLEPYEIEVKVKATGINYKDYLKYNEMIKVNEAGIGFDFSGVVSRVGIKSSKEFKVGDQVYGIAYETSSSHIIIDSLLACHKPSKITHVQAASIPAVYSTSLYCLYDVGNLRDEESVLIHSGSGGVGLSGLEILKSNNHSSPIFVTVGSEEKKQYLINTYGDLITGIYSTRDTNYQKQIKNKLIELGYETHGVDLIINTLSSEFMDTNFKCLNPKGRIVDLTTTHLNPNEFIDNSRYRYNIGYNSIEILKVGKSTIKKLLQSISKSIENETLNALIPITEFSNSNIKKSIESIKERKHVGKIVISHDTDIIDKLIEKESMIDYSILKSDYKIKNLGKNVLVTGQTGLILEVLKWITKYNSTVENIIILSKSSLKWELEFLMNYNNNNNNNNNNNKIKYHFKKCDISNWNLINKTIDQVLKDNPTITNIDSIFHFAALQINKKLKDIDMNSLNVSHSAKTFGAVNLHNLSIKRDWKIINFILASSVVSVLGSFDQCSYVSACCVVDSLSQYRKSIGLPSFTINIGGVSDRGYLSRHKLVEAVLGGQGVELISPNQLLGTLDLQIQNPNMPTNAFVNNFNWPLFKSFKQKLHQKFDFILNPINVDNSISMENDTNQSSSSTNVKNKFLNKVSELLSIDPSKINTNIKMINYGADSLITVQLKNWVDKEWSPHLITIQQIQSNSIGMVYQIINDSLDKKKKEMDEKLLPITAKTTTTTKNDPNDKTEYKYIAGGDCCREFSIKFHYSSVVNFII
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSFRKALKSRQKNHHERSQPGFRKHLGLLEKKKDYKLRADDYHKKQNTLTALRKKALEKNPDEFYHKMINAKLEDGVHIMKKGQEEVMTEEQKKMMRTQDIGYVEMKRVAETKKIERLKGELHLLDAEGKQRNKHTFFVDSKNEVETFDLANHLNVPPELLDRVYNRPTLQTLETKSIKGAVEPGSIKKLARERKHQYRILSQRIDREKKMFIISQKIQTRKDLQEKTKKVKVKKETANSAAIYKFESRRKR
The following text describes a protein:
Function:
Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSQDIPEENLPAEQDRPHGAAARPADETNPFADPGLPPHEPRVQDVDERAAKRSERTVALLFTLSMLATIAFIAAFVAIDVDKSVYIFPLGHISALNFALGMTLGVALFAIGAGAVHWARTLMSDEEVADERHPIEASPEVRAKVHADFKQGAKESVIGRRKLIRNTMLGALTLVPLSGVVLLRDLGPLPGTKLRHTLWSKGKLLVNMNTNEPLRPSDVAVGSLTFAMPEGLEEHDEDFQNEIAKAALMIIRLEPDSIKDKRELEWSHEGIVAYSKICTHVGCPISLYEQQTHHALCPCHQSTFDLADGARVIFGPAGHALPQLRIGVNDEGYLEALGDFEEPVGPAYWERG
The following text describes a protein:
Function:
Has peptide-independent ATPase activity.
Subcellular Localization:
Microsome.
Sequence:
MAGEMTILGSAILALLLAGYLAQQYLPMPTPRVIGIDLGTTYCSVGVFHPGTGEVRVITDENGHQSIPSIVSFTEKDVFVGYDGLELADANPQNTIYDAKRFIGKIFTQEELEKESVRYQFKVLNRNGDVFFSVSTNETFAVTPEYISSQLLLKLKKMAEDYLGLPVSKAVISVPAEFDERQRNYTVKAANLAGLDILRVINEPTAAAMAYGLHKVDVFNVLVVDLGGGTLDVSLLNKQGGMFLTRAMAGNNKLGGQDFNQRLLQYLYDKIYTRYGSVPSQKEEIHRLRQAVEAIKLNLTLHNSSWVRMPLTLASTHPDSSKPDKIIPNESLENTGEIHPKSAHLGDSYSSSGPQIQNKHAEKVYFEMEITRHIFETLNEDLFQKILIPVEQVLKEGHVLKEEVDEIVLVGGSTRIPRIRQVIRDFFGKDPNTSVDPDLAVVTGVAIQAGIMGGSWPLQVSAIEIPNRHLRKSNFN
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSGKAERLKDEGSRLQVTAAGATAGLISRFVIAPLDVVKIRLQLQHHSLSDPLLHQRRAEIIGGGPVYKGTLPTIRHILRTEGLTGLWKGNIPAELLYVSYAAVQFTTYRSITQFLQAAFPKDQNKQLPPSVESFIAGASAGGVATAVTYPLDLLRTRFAAQGVERVYPSLVQALKTIYASEGVTGYFRGLGPGLAQIIPYMGTFFCVYETLRPRLSKLELPYSSGSAVAGVLASVMAKTGTFPLDLVRKRIQVQGPTRGMYVHKNIPVYDGGMVKTVATIVRREGVRGLYRGLTVSLFKAAPASAVTMWTYERALKLYIRLGAAGPGRKEGV
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MVRLREIPRTAAFAWSPGANPLLVTGTRSGAVDADFSDETKLELWDLKLDSQEQGLELQPIASITAESRFYDIAWGQPNDEHPRGVIAGAMENGSLDLWDAEKLIAGEDALISRTTKHTGPIKALQFNPLRPQVLATAGAKGELFVWDVNDTSAPFRLGTAAAHDIDCLAWNPKVANILATGGAGGFVTVWDLKTKKASLTLNNHRKAVSAIAWDPENSTKLLTASSDDTAPVILLWNLRNSQAPEKTLQGHDQGILSLSWCQQDAGLLLSCGKDNRTLIWNPQTGERYGEFPEATNWTFYTRFNPHNPNLSATASFDGKIAIQTLQNTNPSAAPAAQNNLSDDDFFSKAASQPQAASFSLPRAPAWIERPVGVSFGFGGKLVFFNKVETAAGQKRSSKLQISSFSIDSDIGSATDKFEQAIQSGDIASICEEHIENAKTDEEKAEWQVMQTLSESDGRTKIIERLGFIKDEPVEEAKEAESPMSPEPKQEDSASLKPNGGEAKKHRRVVSMWGDGDDGEDFLSEIAATKGAKTDNPFNLLSVGNTHLEDQITRALILGKFEKAVEICLKEERWSDAFLIANCGSKELVEKVQTAYLQQKRGSPSYLRLISSVVAKNLWDIAYNADLADWKETMVTLCTYADPSEFPDLCEALGDRILESGNRKDASFCYLIGSKLEKVVGLWVDELQETEQAALNEEAGDSTFSVHAKSLQQFIEKVTIFRHVTKFNDSETSLTEGWKLAALYDKYLEYADIAAAHGQLSVAQKYLDLLPTSYPPAETARNRVRLATQKAGAQTAVRQATPAGRTTTTTSSRTAAPVGYQQPSLVPAPANPSSLNPYAPPVPAPVSAAASNPYAPPLAPVSAAASQYGASSSTYAPPQNQGYAPSGYTPPTQSYAPTSVTGYGVPAQNFGQPSPLGGPPKATAPPVQLKRDGVWNDVPMVTKAPPRRNTPSVAPLTSPFPGQPGIASPPPAGPFQQGAPTPPPPPKGSAPPRNVGAPPTGPPRPSSVSSNATNPYAPPPPAAGLQPTYGVPPAPRTASPYNPPPSAAAPPANRYAPAPATQQYTQGPPSGSGIAPPPASGAYTPAPPAASQQYAAAPPPPRAGFSAPPPASRPPGGGPPPAAGAPPQQQAPPPAAPPKPRYPPGDRSNIPEHAKELVDILSRDMQRVASKAPASFAPQVKDTQKRLNILFDHLNNEELIKTETIDQLAQLAGALAGKNYDIASKIQVEISKEKTEECGQWMVGVKRLISMSKATP
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MLITIKTLKQNIFKIEIDEEEPVKVLKEKIAKEKGNDNFPVAGQKLIYAGKILDDSKSLKEYKIEDGKFIVAMVTKPKSVSPPAPTPPEPTEAAVTTTTSTQEEQPTNQPAVASTTSSSPAEEQASSASPLNVTGEAYNELVTSIMAMGFERERVVAALNASFCNPDRAVEYLMSGTTNVGTAPPQQQPDTIPTENAPISDSNVFNDLMDNPEIQVMAQQIQQNPHLLQPYLQQIEQSNPSLFNMVSSHPEEFVSFLTTLRRGTSQTQPPPASAGAGGVSYVRVTAGEQQDIEQLKSLGFSESECVQAYMACDKNLDMAANFLLS
The following text describes a protein:
Function:
May have a role in pharyngeal pumping during feeding.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAKQLKYPFLIFIISLAQCQVSNQNVNLCQSNICQNGGTCLVASSVPATATCPKNSIYYMGSCYVFDTTLRNWNDAALYCNNMNSATLPLVESAEDQAFFAGYLQAMIPSNPPADMRPPPDGIWTAVRGVNNVTRASWVYYPGSFLVTDTFWAPQEPNIYVNYNDVCVALQSDSFYREWTTALCTILKYTVCKVAPTQIQAKYVAQCSCPNGYGGQTCETQSTTNQQASTQRTCGSNDFQFSCPNDQTITVDFASFGAQESSMCNQASQSREQTCSNVNSLQTVINACQGLQSCEIRNLTSTFSNTPCPVPQEQYLETRMRCETAQQPSCLSGLIQFDSRCYSMTIETNEKKQRTMEDAQTYCSQSGGSIITSPPDALLQQIVQKVNAETKKTVNFWIGTPNNCQLLMVTGSSTSYSQCPSSPSSTANVICSTVPQSTASVSARPTQSAPVDPVSQTMARREVYTGVQPPSVPDSINKPRYCKKEKKDGITYEQTRACMLHEQPCPDPQNVEGTVTRYCNCQTAKWETPDTTNCTHRWVAEMETAIKDNQPVEDISSTVNRQLKSTIERTLFGGDITGTVRLSNDMLSLARNQFSVLNDRNLRENKARNFTENLGGSGDQLLSPVAATVWDQLSSTIRIQHASKLMSVLEQSVLLLGDYMTDQKLNLQYINWAMEVERSEPEVQTFGAAASPNVQDDMGMMRVMAAAPPAPQPETNTTIMFPSLKLSPTITLPSASLLSSLASPTPVAGGGPSILSSFQDDTPVGMASTPNLNRNPVKLGYYAFAGFGQLLNNNNDHTLINSQVIGASIQNATQSVTLPVDHPVTFTFQHLTTKGVSNPRCVYWDLMESKWSTLGCTLIATSSNSSQCSCTHLTSFAILMDISGQVGRLSGGLASALDVVSTIGCAISIVCLALSVCVFTFFRNLQNVRNSIHRNLCLCLLIAELVFVIGMDRTGNRTGCGVVAILLHYFFLSSFCWMLLEGYQLYMMLIQVFEPNRTRIFLYYLFCYGTPAVVVAISAGIKWEDYGTDSYCWIDTSTPTIWAFVAPIIVIIAANIIFLLIALKVVLSVQSRDRTKWGRIIGWLKGSATLLCLLGITWIFGFLTAVKGGTGTAFAWIFTILNCTQGIFIFVLHVVLNEKVRASIVRWLRTGICCLPETSSAAYNSRSFLSSRQRILNMIKVNGHSYPSTASTDDKEKQLTPITKTTDWLSRLPNQDSVSIPESNFNNLNGTLENSNLNSAEIKEEDEIPELRRRVTVDLNPMIVSNNEIERMSHASSDPRGSQIIEVTAVEKKAPVKRIKFPLGAKQSERGSQHRTKAKVIAPPESPVSESGSKDYRF
The following text describes a protein:
Function:
Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MAAGVDEKDKKTIVFLHPDLGIGGAERLVVDAAVGLQNRGHKVVIFTSHCDPRHCFDEARDGTLDVRVRGNSIIPPSLLGRFSILCAILRQLHLILQITLLTSELRTLSPSAFFVDQLSAGLPLLKLLVPTSPIFFYCHFPDLLLVQGRQTWYKRLYRLPFDTWEEWSMGFADSIAVNSSFTKGIVSHTWPSLASKRSLEVVHPCIDVRSTSDSSQNPNDDDKDVLPWTKTGIILSINRFERKKDIALAIKAFASLSPEQRGKAKLIIAGGYDNRVHENVSYHMDLVDLAEGAPYHLKTATAKTVVSALNTSPDVEVLFLLSVPNTLKEILLRSAKLLVYTPSNEHFGIVPLEAMLRGVPVLAANNGGPTETVVEGETGWLRDPNDVGEWAKVMDKVLNGMGEEELKRMGKKGVERVKGRFADTQMAERLEEIIERMPKGDAAQSGMILLVVGAAVAAVAGVISAVYWKLW
The following text describes a protein:
Function:
[Pancreatic polypeptide]: Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions probably by signaling through the G protein-coupled receptor NPY4R2.
Miscellaneous:
MISCELLANEOUS: May be used as a marker of the viability of xenotransplanted fetal panreatic tissue in the immediate post-transplant period.
Subcellular Localization:
Secreted.
Sequence:
APLEPVYPGDDATPEQMAQYAAELRRYINMLTRPRYGKRDEEDLLDLKCSSLHAAAPRELSPMGA
The following text describes a protein:
Function:
May be involved in maintaining Golgi structure and in intra-Golgi transport.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MSSWITGLADKAENILNKLDQNAATALQTENATGSADPMRRSMTSSTQSLSTSLKSTLSPVRRSGANSSSSVKSDGGVSVVTKDMRQKMTTSASFSNSPDISANSMDTNELAAFKIALNEITAERDELRLRLEDLNNETEKFDLHQHTQVLEALVKSLSEERDKAVHDYNEAQAANMAYVHSISELETNLAKLQQEYISAAHKLQMQTKETEQQRQELQEYRIKAQRALQAKDSLIAELKAKPTEEGADPNLVSKDSETRFLQIEHESLKQELEHANEELQKARLQLDDYVSQERQRQVELSSARQREETLAKELRQAREHSVTSESDQRVLTQELASLRQQLSNQMAAAATRLQEREQQLQQMRQRLSEEANTGAKSDYETRLKALTQSLVERQSLLERVTSERNALRLQHEKAQTQLQQNMHLVEMESQRGSSRHTMLNSTDDVKAQFPLLMHPSPFDNRVARRFKRALRQADSMGIRVGTFLRRYPMMRVSVIVYVALLHLWVMFVLLSTTPN
The following text describes a protein:
Function:
Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity). Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity). Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity). Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity). By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=In a subset of CD4+ T-cells, colocalizes with SCRIB at the immunological synapse during the late phase of T-cell activation.
Domain:
The extracellular domain is required for the regulation of IFNG and IL22 production, but is dispensable for late T-cell polarization.
Sequence:
MWWRVLSLLAWFPLQEASLTNHTETITVEEGQTLTLKCVTSLRKNSSLQWLTPSGFTIFLNEYPALKNSKYQLLHHSANQLSITVPNVTLQDEGVYKCLHYSDSVSTKEVKVIVLATPFKPILEASVIRKQNGEEHVVLMCSTMRSKPPPQITWLLGNSMEVSGGTLHEFETDGKKCNTTSTLIIHTYGKNSTVDCIIRHRGLQGRKLVAPFRFEDLVTDEETASDALERNSLSSQDPQQPTSTVSVTEDSSTSEIDKEEKEQTTQDPDLTTEANPQYLGLARKKSGILLLTLVSFLIFILFIIVQLFIMKLRKAHVIWKKENEVSEHTLESYRSRSNNEETSSEEKNGQSSHPMRCMNYITKLYSEAKTKRKENVQHSKLEEKHIQVPESIV
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) signaling during germination and early seedling development. Involved in the regulation of vegetative development and fertility. Modulates red light signaling in seedling photomorphogenesis.
Miscellaneous:
MISCELLANEOUS: Seeds over-expressing ZFP3 are insensitive to inhibition of germination by abscisic acid (ABA). Plants over-expressing ZFP3 are dwarf, have reduced number and size of siliques, which contains few seeds or are empty.
Subcellular Localization:
Nucleus.
Sequence:
MDASIVSSSTAFPYQDSLNQSIEDEERDVHNSSHELNLIDCIDDTTSIVNESTTSTEQKLFSCNYCQRTFYSSQALGGHQNAHKRERTLAKRGQRMAASASAFGHPYGFSPLPFHGQYNNHRSLGIQAHSISHKLSSYNGFGGHYGQINWSRLPFDQQPAIGKFPSMDNFHHHHHQMMMMAPSVNSRSNNIDSPSNTGRVLEGSPTLEQWHGDKGLLLSTSHHEEQQKLDLSLKL
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.
Sequence:
MQTTQRVQTPRSRLPALGRCTPRRLHFARPQHVAAQQRRAVLAHGAATDDTLTADVVIVGAGIVGLFAAADLLKAGLSVALLERQGLCAGATGAGQGYLWMAHRNPGSVGWALAARSVALWQRLVAADPAFRAAVEWQDCGSLLVATSPAEAAALSERQMHLNEVGVRASYMDGRRLADAEPGLALPHGGAALLVQADTQINGRKAAHVLLEQCRAAPGFTDVMGEGGEVQGLELAAGPGGGHVVQTKGGRVRARHALVLAAGVWTGGLLAAATHDPEWKALLQPRRGHLLELPQPAGMPRVVHGMMEMSYTKHYAHASAPTAPVSAPVSAPVSAPMSAPAPGSGSAEVDITFTATTSASGSLLIGSSREFSGWEATPSPAVVSAIMQRAALFLPGLQPAAAQAAAAAAAGAGSSSSSSSSSSGDSGVPGMSVRVGLRPYAVGGLPMVGPVAGAPGLFVAAGHEGSGLCMGPATGQLLSRHVRKHMGATATATAPSSSPSTSAAVAPAAPATAAAAGTKADSLDTASFQDLLPDVRRKAALAKAGTK
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section (By similarity).
Subcellular Localization:
Cytoplasm. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSKSDFWILSVPSRGGSNADLCDDIERLLVSGSTSLISTVAPFDVPPFKVESLDVLISQSEQLTKQDAQCASAISKISDIIKNTVSSSSGDLKDYFMVQDKSPLEYVSSFAWNSSRFHMNKTISEISDRITSEIISFENDIRTRQTSFQQASSAFQNMQKKQSGNLSQKSLANIVHEEDVVHGSDYLTNVFIAVPLNLEKQFLNSYETLTDLVIPRSAKKLDQDSEFVLYTVVVFKKTADSFITKAREAKYTIREFTFEQGLRETEQSEFDDAAVKEKRMLSSLLRYASIAFSESFQGWIHLKCLCVYVESILRYGLPPDFSSVIFQPMAKSEVKIKNILLSKYAYLAQNPVGNNKVKNVDSSAGLDESMADLNLDEEYLPFVLFTVPSKVFNY
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized multi-pass membrane proteins like rhodopsins.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MCDYKVSERAYAKLIFHAAKYPHQAVNGLLLAEKTSKGSQVEIVDAIPLFHQCLYVTPMAEVALMLIDAHAEREGLVIAGYYAAPENFYDNQVDKTPAAKIADKIQENFKNACFVVVDNKLMTLQHDRAAIQVFNCPGDSGARWSKAKFTLSQASDTLEGVSLLLKRGAMRDLVDFDNHLDNPDKNWTNDFLNQPLNDLQKLY
The following text describes a protein:
Function:
Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2.
Sequence:
MASHASCIFCKIIKGEIPSFKLIETAKTYSFLDIQPIAEAHVLIIPKHHGAKLHNIPDDYLSDILPVVKKLTKVLKLDENNTPEGEGYNVLQNNGRIAHQVVDHVHFHLIPKKDEATGLGVGWPAEATDFDKLGKLHEKLKEELAKVDNEKL
The following text describes a protein:
Function:
May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation.
Subcellular Localization:
Secreted.
Sequence:
MAAGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFKEAMLQAHRAHQLAIDTYQEFISSWGMEAYITKEQKYSFLHDSQTSFCFSDSIPTSSNMEETQQKSNLELLHISLLLIESRLEPVRFLRSTFTNNLVYDTSDSDDYHLLKDLEEGIQMLMGRLEDGSHLTGQTLKQTYSKFDTNSHNHDALLKNYGLLHCFRKDMDKVETFLRMVQCRSVEGSCGF
The following text describes a protein:
Function:
Cell cycle regulator that is involved in modulating and adjusting cell proliferation according to the requirements of the developmental program. Interacts with mitotic Cdk1-cyclin complexes to inhibit mitotic entry at the G2/M transition. Likely to function by binding to the hydrophobic patch of cyclins to interfere with the interaction between the complex and certain Cdk1 substrates. At the mid-blastula transition, involved in the cell cycle arrest in G2 of cycle 14 by delaying mitosis and thus reducing cell proliferation allowing cell fate specification and morphogenesis to take place. Acts downstream or in parallel to the checkpoint regulator grp which is also required for the cell cycle pause at cycle 14. During gastrulation, delays mitosis in the ventral region of the embryonic mesoderm thus allowing invagination to be completed before cell division takes place.
Subcellular Localization:
Nucleus. Note=Associates with chromatin in the syncytial blastoderm.
Sequence:
MSSTNETNQVLQRLNSLKIVETPKEQHEFGKRECYSLDSKKYSLVPATPSSSGHGKFQTELKKRRKNKLNRMYTYEADKNFIKARKSLNF
The following text describes a protein:
Function:
Probable chloride channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSQKRDSAGGDLWWKSLAPQEVPSPFLVFAFHPCGRGAHGNSEEKSRDEGSPRPSAPLISNSDRECEPLEPLIGSLICFLPSPAASCSLHGERITQRRRCSEAPRAVFIDPKTPSLGILIAVPGFWLILTLLAFLIFFLCRCCDSGLKKKRRLTPLKWTLALFALLCCGALALGLFGNDQAHGGMVAVQKSTQDMEDSLSSMGNQTRFLDRSLGQSAQQELSGLALALAGPLSDPAARNLLDRSLELMKGNLSVGAARAQELHSRVGHLTLSPLPRALQLVELFRWPATIGLLCVLILVCLLLLWGVIRHSRCLLILFSVLGLLSVVLCWVMVSLYLGICVPLRDARGAVDGLQTLLVPVTHVADRYFPRKEVSALCRRLRLGNKPPHLGQELNSTQTVLAQLGLLLDCRHIHQQYRSAMGATCTGLLEGTAFMLASAAGAGLLFTVLIWVASHTWIHIRQRRPREALDEEDPFLPPSAVGGAAARRSRDTNGRSASREEQAFLQARYTPPPTRVRRSILRVLPSAEGYKAHFLPSFIQQQRTEAIISEASYKKVAPNHHRLKGTCWDTGRLEACLLHSPQFSPVFSLEELDLTS
The following text describes a protein:
Function:
Serine protease that is required at high temperature. May be involved in the degradation of damaged proteins. In vivo, can degrade beta-casein.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side.
Sequence:
MATTTSCSLLLSSTLFLHSPPSSHLSFFNLSSSRSSPISLYPIRSKRYFRILSKLSLNDNNRDDDDDTLHFTPFSAVKPFFLLCTSVALSFSLFAASPAVESASAFVVSTPKKLQTDELATVRLFQENTPSVVYITNLAVRQDAFTLDVLEVPQGSGSGFVWDKQGHIVTNYHVIRGASDLRVTLADQTTFDAKVVGFDQDKDVAVLRIDAPKNKLRPIPVGVSADLLVGQKVFAIGNPFGLDHTLTTGVISGLRREISSAATGRPIQDVIQTDAAINPGNSGGPLLDSSGTLIGINTAIYSPSGASSGVGFSIPVDTVGGIVDQLVRFGKVTRPILGIKFAPDQSVEQLGVSGVLVLDAPPSGPAGKAGLQSTKRDGYGRLVLGDIITSVNGTKVSNGSDLYRILDQCKVGDEVTVEVLRGDHKEKISVTLEPKPDES
The following text describes a protein:
Function:
Regulatory protein for the xylBAFGHR operon.
Sequence:
MTEQYYKIALLFNANKVYDRQVVEGIGQYIQASQCMWDIFVEDEFIYHTDTINQLSIDGIIADFDDPKTVELLQHTLIPTIAVGGSYKQADFYPHFPYIATDNMALVEMALSHLQEKGLSQFAFYGLQVNTHKHWSIERRDAFVELMEKNHYPIYLYEGVQVHAQNWLEEQQKLIVWLKSLPSHTGIIAVTDARARHLLQACEYSKIAVPEELCVVGIDNEELIQYLSRMSLSSVEQGTREIGYQAAKLLHKLLNGQKVSHTPILIPPITVHSRNSTDYRSLTDPLVIQAMHYIRHRACHRIKVGQVLDHLETSRSNLEQRFKNEMNKTIHQVIHEEKISRAKNLLQQTDISIKEITEICGYPSIQYFYSVFKKEFEMTPKEFRLNC