lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Iron/ascorbate-dependent oxidoreductase: part of the gene cluster that mediates the biosynthesis of domoic acid (DA) and derivatives, natural products with neurochemical activity acting as ionotropic glutamate receptor (iGluR) agonists, thus being neurotoxins causing amnesic shellfish poisoning (ASP). Catalyzes the conversion of 7'-N-carboxy-L-geranyl-L-glutamic acid (cNGG) to isodomoic acid-A. Also mediates the conversion of N-geranyl-L-glutamic acid (L-NGG) to dainic acid A.
Sequence:
MTVAINNETVVLTPNEDDVQVNKGKTLETSFPPLKGDDLKWFPRSSLPAEIPAIDIGKVSTKEELEQFLVDIRKSGLFYIVNHGVPEEVSINVYNAFREFISTTTEEERMKYYTDTHFQNGGYVPFQGSSIRGGNLGKPQKDHVVKYFWRGPEVINRTPNEKFTEAHNMHHTETFKVAEKVIRTIFKALKLRFPDFDPMEFENTINSKKMFFTNRIYPQAEPSDEEEITHRLVPHLDTSFITLANQVPADNGFQGLFVETGDGKKVKVPGIRNSYLVFIGQSLSYLTKNYLPSALHGVDKPPSDLFEGSERSSLITFYEPAEIIIPSKNINPNPEETSESCPFFYDIGLTVNDPEGTTWDFVKNKFITGYYAD
The following text describes a protein:
Function:
May deacetylate chitin (Probable). Required for spore formation.
Subcellular Localization:
Prospore.
Sequence:
MYETRDLTGNAGKPVDTNPWPNNSKIAVSFVVNYEEGGERSLLYEDEGFETFLTEAGLMPFPNRPVRERSIESCFEYGSRCGFWRILNLFKKHKVPFTCWAIGQAVEKNPVVVGAMEEAGCEVGSHSHRWINYEGVPPETEYEHIKKSVQAIQKASPSNSAPRSWYTGRASLNTRKLVCQVYKDLGLPQPFDSDEYNDDYPYWVADPLASKPGAEDDKGLLIVPYTLEVNDMKYAVAPGFCNSDDFYTYARDAFDVLYEEGLEGAPKMMTIGLHCRLTGRPGRFRGLQKLMEHITSKEGVWVATREQIAQAWSAKHPYKA
The following text describes a protein:
Function:
Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).
Subcellular Localization:
Synapse. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane; Peripheral membrane protein. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to dense core vesicles but not to synaptic vesicles. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2.
Domain:
The PH domain is essential for regulated exocytosis and binds phospholipids and plasma membrane. It however does not mediate binding to DCVs (By similarity).
Sequence:
MLDPSSSEEESDEIVEEESGKEVLGSAPSGARLSPSRTSEGSAGSAGLGGGGAGAGAGVGAGGGGGSGASSGGGAGGLQPSSRAGGGRPSSPSPSVVSEKEKEELERLQKEEEERKKRLQLYVFVMRCIAYPFNAKQPTDMARRQQKISKQQLQTVKDRFQAFLNGETQIMADEAFMNAVQSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVRSLPEIDGLSKETVLSSWMAKFDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGRLQMADQIARERKFPKFVSKEMENMYIEELKSSVNLLMANLESMPVSKGGEFKLQKLKRSHNASIIDMGEESENQLSKSDVVLSFSLEVVIMEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEASKPTWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQSEWHKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWAIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTDPQPGLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNAKGGNVPQLDAPISQFYADRAQKHGMDEFISSNPCNFDHASLFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVHGNRPDGIGTVTVEEKERFEEIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYSRLSEYAKIEENQKDAENVGRLITPAKKLEDTIRLAELVIEVLQQNEEHHAEPHVDKGEAFAWWSDLMVEHAETFLSLFAVDMDAALEVQPPDTWDSFPLFQLLNDFLRTDYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVKSLTSNLPNVNLPNVNLPKVPNLPVNIPLGIPQMPTFSAPSWMAAIYDADNGSGTSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSRSTDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYDEGTLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQWYNSSMNVICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQGVLDSTLNSKTYETIRNRLTVEEATASVSEGGGLQGISMKDSDEEDEEDD
The following text describes a protein:
Function:
[CLE8p]: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Positively regulates the expression of the transcription factor WOX8 and thus, regulates early embryo development. Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2.
Subcellular Localization:
[CLE8p]: Secreted, extracellular space.
Sequence:
MKVLKRDSMLLLITLYFLLTTSMARQDPFLVGVEKDVVPAGTDLKQNKAKPHLPNLFRTMRRVPTGPNPLHHISPPQPGSLNYARN
The following text describes a protein:
Function:
May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Interaction with COPS2 may regulate localization to the nucleus.
Sequence:
MLSSAHVVPTSVRRAPSWICSSSRSFMDLKALLSSLNDFASLSFAESWDNVGLLVEPSPPHTVNTLFLTNDLTEEVMEEALQKKADLILSYHPPIFRPMKHITWKTWKERLVIRALENRVAIYSPHTAYDAAPQGVNSWLAKGLGTCTTRPIHPSKAPNYPTEGTHRLEFSANHSQDLDKVMSAVKGVGGVSVTSFPARCDGEEQTRVSLNCTQKALMQVLAFLSQDRQLYQKTEILSLEKPLLLHTGMGRLCTLDESVSLATMIERIKRHLKLPHLRLALGVGRTLESPVKVVALCAGSGGSVLQGVEADLYLTGEMSHHDVLDAASKGINVILCEHSNTERGFLSDLQEMLGVHLENKINIILSETDRDPLRVV
The following text describes a protein:
Function:
As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus, nuclear pore complex. Nucleus, nucleoplasm.
Sequence:
MATNGINEARTSISCENIPELFLDKLTAKMHFSQFGKIKRFILRPNRLSCTVEYEQPESAQQALERGGQFKNVSFSIYWTDLKPPSVNDNGKAGGSLDLDVQMELEAIDNVRSPSQNLLAYYKGGEQRTAPPVTNNRPTLAKLSMPVSARNETDPKIGQARMELETLANKPAFSAEERCRVLEAKDRYIRLTTERTTDIRKAKNIVGTCPDMCPEKERYLREWKCMVPSYERQTGGGAQIDHVKAIKQYSRSSADQELPLPHELRSQQALGRTMHFLLTHLADLCNDDEGEGGGNVSDWFHYIWDRTRGIRKDITQQDLCSVTVVELVEQCTRFHIHCAARLVSEDPSVFDQKINTENMTKCLQTLKYMYTDLGQRGQRCPAEAEFRAYMVLLYLNDGNFLWELRQLPEAIIHSKEIQFALSVYFALEENNFVRFFQLVRSTTYMNACILLRYFTQVRQKALEILRKAYAVRSTASFSLEYMTRILGFEDEEQAEAFFDHYGIMIDQTTDMVLFEPRQMNFYQPELPFPTSRAVRLVESKRTVSVGEAICGRPLEQWELQLPMVQPPNDSFDESGCLKEEVLQNVFADRRLSQEKSESRVQKPQLVKDDRELHAIEEDKLDSMEPDAPNEPMADDRLFKVPSPTTVVPRLSPRARTPPTKPVPAPFPAEQNATPALPPPVFGTIGAKTAPSSVETAGFKTSTEAPSSFSFANAFAKPVFGTPPSTGNAPANSSVAEGGSLFGAFKSTPIPMAGGNLFGGVSNVAGSQSDSTDRVTMSWVNPPQNTAITPAGQKRAFHGAVKDTSPAKPPAPVTVSGRSFFQAKPAELLPSSNPSGGSLFGSANSFGGTALFGKAPSMPAAFGSSPALTAGFFQQPLKERNDNRENVGIPVERKEPNVDAEIEKQREKLKQEEEKRKQEKLLEERKQAVERASTVELEKLIDLVVEELVPEIAEAALDRQKRIQRTAVDVFNELVAELLTSHVTKTAEQEIERVERLRAARVRKLSMKYFHRWHRNAKSAARWRRLMRTVPPSFVNGSIRMDELPRCDQLRPFLNARCTGSKRSVDSVLQDQSVLREVFLFDAFPERKLIDPFVQLEGMINQLQQMQVPTRILGIAEPIYWKLVLSLPVEGEEGSAGFPSFVKRWLECCAFRKENREENHPYFYLAKRSPPSKQMLGTKTHSKGDGSQGQRAICMRLLQGQSLISEKDTDRAEACVLTDGVLFFLSDRCQIEQARNRLKSILTKCGSHQPSIAVILYCPNTVGAESSLVSVDSFEQNLGLAAGIVKRWRVFLWSRGTENDTLREAVHYLAHCYRAQMQFEPPRYEERLEMRPLNDFLERCVGSELWFRFDKSCRQSRGYLLAGKNANAIVELYNTAISKVQAMVSQDLNQFVRLPEEFGKLRDQASVATTRTNLLPLPEAYFPPDWNDTKRKNQLIQLLKPLKLHPLPDSLLAAIDRAAQASTSQGVAIDVAELRKELNEYLSSYRVPLAENPHELSALTQQFLQGIASQLAGYAYNTETRPKERFGENVRRCYWVPLLALISETILRVLLKRAEGGSSLPHEVCYRRIDFLHHTETVWWKAQLQQIQKEALGSIEASRSNTPDTLALSPPSSSTTSAQDRKRAHTELAHHNECNASLNSVVSGSDTSFSDSIRSANFHKRPKIVNGVIYSREIVDDVIAQGMRALVRAEELLSQKQNHATELQRIFKPLETTIQEVEQTCRNIQYKHGSRASK
The following text describes a protein:
Function:
Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
Sequence:
MIFRPTPLSGAFIIEPEPRGDARGWFARVFCTQEMAQAGLVDQFVQVNNSFNAEAGTLRGMHYQLPPAPEVKIVRCIRGALWDAIVDLRPDSPTYLQWYGVELTADNRLALYVPRGFAHGFITLQAQTEALYFASAMYTPAAERGLRWDDARIGIRWPCTPALVSDKDAAWPEFNEQVHGVTQLTGLTQQERA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDILNVESREPALPLSALRLVVPPLRLMSAFLWQVIQRRNVTQYGKLEQFVNLVTENVPDIMSRSLVNKLIFHMRKKVILELCLKDKMPDLWIIQAHLDSLRNLTHKCKDVESEIINNKFIRTMHSILEDTEKKEDFLQHIFPVEYGSGYDAVLQSLAWEFLSRVEDLLPVPNLKETASRLCGGLSMMEEIVQPLSDPAEIKDVLQHFKSKRLHTINNEDSPRVISEMSIPSAAEVVCLPHPIAQETMSPTITIEQEEPLPPTSIAQETIIIESEATENQSESDHAAIAIMSPSQSYTEEAETLAVTEEFATIEEAEDGLQQEETLCEEKDSGICEVQQIYLTADGSTVVVSEFDNEGEEVQFLEQSEMVETPGVRQVSLEQWISELTGKGVSLPVLPPTPVEIVREETIFVPVIERPPSVKSIIHRKSSPPRAAVSKKSASASLESQTTQDEKRHACPECHKEFRFECLLRNHMRTHTGERPFQCSDCGKSFRCLSFLTNHIKTHSLARPFKCSQCIKTFRKKADLIKHIRVHTGEKPYKCTICGKSFSQGSYLKIHRECHTSENLHQCPHCDKSFPTAFKLSIHVRYHSMERSYKCSQCGKSFIYASLLRRHKGYHAGERQYLCSICGKSFVYMFDLKKHQRNHERPRLKIPCTLCHKTFAGPEMLRCHLRIHTGERPFRCKICGKAFSQIGNMKRHERVHTGERPFTCERCGKTYKHSSHLKNHMLSHTGERPWQCSHCGKSFKFAGPLKKHERTHLGERGNRRRSYDQTRGRAKPDPKSP
The following text describes a protein:
Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Zona pellucida.
Sequence:
MCRKVFGFKLSGNPKGARHCSQLPWLFCLVTLVACAAVGHLSATSFPGTVTCYDDEMKIGFPEDLGNESWQADVVDSLGNEILNCAPVMNSENLTLRIMYERCAERVHGRYRVNLRFLPNKITSNQTISYQVSCPATQGDEGRGGILAATNCTKNSMSISFPQILPNFHDDTMISEPQTTWTVIVGDSPRTQTLSLHQAMEQGYTFVTDTNKIILQVSFNAAGVLHYEQENNHLYTLALQLTYGSPEQRLTLSSRLVCLFGPVTCNSTHMTLIIPEFPGELTTINIENQNILVNMSKSSGIALESRNGSRVHFNKRILKSKVSENGAGVQFYLPSVKLIFAYYGDMVPMIINPVSCESPVSVVTDGTCTQDGFMDFEVYSHQTRPALNLNTLQVRDTACLPAFKDPFQEMVRFHIPLNGCGTSAKFERDQAIYENEIHALWEDLPPSKITRDSEFSLTVRCYYSSTDLIVRTNISSPPSPIASVEPGLLSLILQSYPDKSYLQPYRENQYPIVKFLRQPIYMEVQVINRNDPNIKLVLDDCWATTSEDPASLPRWNVIVDGCDYKLDNYRTKFHHVGSSVKYPNHYQRFEVTTFAFVSGGQALSSLIYFHCSVLLCDQSYPDTPLCSVTCPLSSRTKRGKYLKTL
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MKIAVLLSGGVDSSYSAYSLKEQGHELVGIYLKLHASEKKHDLYIKNAQKACEFLGIPLEVLDFQKDFKSAVYDEFINAYEEGQTPNPCALCNPLMKFGLALDHALKLGCEKIATGHYARVKEIDKISYIQEALDKTKDQSYFLYALEHEVIAKLVFPLGDLLKKDIKPLALNAMPFLGTLETYKESQEICFVEKSYIDTLKKHVEVEKEGVVKNLQGEVIGTHKGYMQYTIGKRKGFSIKGALEPHFVVGIDAKKNELVVGKKEDLATHSLKAKNKSLMKDFKDGEYFIKARYRSVPAKAHVSLKDEVIEVGFKEPFYGVAKGQALVVYKDDILLGGGVIV
The following text describes a protein:
Function:
Involved in transporting aromatic amino acids across the cytoplasmic membrane; Transports tyrosine across the cytoplasmic membrane. The transport system is energized by the proton motive force.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTQSKLLGSTLIIAGTTIGAGMLALPLASAGIGFSTSLMIMLGLWMLMAFTALLMVEIHQYADKEATLHTLAKQILGDKGKWVATFAMLFLFYSLCAAYIAGGGAQFTQRITDFTGVNVESSSGTLLFTLIVALVVTVGTGTVDRVNRVLFAGKMIAMVAVLFFLAPNVSQSYLLSMPIQQGLIVAAIPVIFTSFGFHGSIPAIVNYLDGDTPALRKAILIGSAIPLVIYIFWQLVTLGVVSQSALLDNMGLTALIGVLSTTVHQSNLGNIIGVFADLALLTSFLGVSLGLFEFMGDSLRNQQGKMNRPLASVVTFLPPLIFALFYPQGFIMALGYAAIALAILAIFLPLVMVIKVRQQATEQHYQVTGGNGALLVTGLVGLLIIGAQLLITLGILPALG
The following text describes a protein:
Function:
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
Sequence:
MLNKLGRNDLCWCGSQKKYKKCHSAFDKRIELYKTHGHIVPPREIIKKPEQIVGIRKSGKINTAVLDYIADHIQAGITAEDINQLIYKKTIELGGIPAQLGFEGFPKSVCTSINDQVCHGIPSENIVLNDGDIINVDVSTIYEGYFSDSSRMFCIGHVDEDKKNLVNVVKECVNLGIKQVKPWGFLGDIGQAIYDHALKNGYSVVKEIGGHGIGLEFHEEPWVGYTSKKNTGMLMVPGMIFTIEPMINMGTDEIFLDKKNGWTYYTTDGKPSAQWEIMILVTNNGYEILAY
The following text describes a protein:
Function:
Plays a role in the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Stress-induced regulatory protein that modulates the m7GpppX diphosphatase activity of DCS1.
Miscellaneous:
MISCELLANEOUS: Present with 1870 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, P-body. Note=Predominantly cytoplasmic. Localizes close to the perinuclear space before the diauxic growth shift. Recruited to the P-body after the post-diauxic growth shift. Colocalizes with the decapping activator protein LSM1 at P-body.
Sequence:
MGSQDLASLIGRFKYVRVLDSNPHTKVISLLGSIDGKDAVLTAEKTHFIFDETVRRPSQSGRSTPIFFHREIDEYSFLNGITDLKELTSNDIYYWGLSVLKQHILHNPTAKVNLIWPASQFHIKGYDQQDLHVVRETPDMYRNIVVPFIQEMCTSERMKWVNNILYEGAEDDRVVYKEYSSRNKEDGFVILPDMKWDGINIDSLYLVAIVYRDDIKSLRDLNPNHRDWLIRLNKKIKTIIPQHYDYNVNPDELRVFIHYQPSYYHFHVHIVNIRHPGVGEERGSGMTILLEDVIEALGFLGPEGYMKKTLTYVIGENHDLWKKGFKEEVEKQLKHDGIATSPEKGSGFNTNLG
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular Localization:
Cytoplasm.
Sequence:
MVAAKKHVPIVKKRSKGFMRHQSDRFMRVDSAWRKPKGIDNRVRRRFRGTLAMPSIGYGSNKKTRHMMPSGHKAFLVSNVKDVELLLMHNKTYAAEIAHNVSSRKRIEIIARAKQLSVKVTNAKAKVTTEV
The following text describes a protein:
Function:
FMRFamides and FMRFamide-like peptides are neuropeptides. Induces sleep-like quiescence behavior following release from RIS interneuron. Helps to sustain locomotion stop after gamma-aminobutyric acid (GABA) induces fast slowing response. Inhibits the late-stage body bend swimming frequency in animals through several receptors including frpr-3, npr-4 and npr-22; [AMRNALVRF-amide]: Potent inhibitor of the activity of the dissected pharyngeal myogenic muscle system. Acts as a ligand for the npr-22 receptor in vitro; [ASGGMRNALVRF-amide]: Acts as a ligand for the npr-22 receptor in vitro; [NGAPQPFVRF-amide]: Acts as a ligand for the npr-22 receptor in vitro.
Subcellular Localization:
Secreted.
Sequence:
MTQFSALALLLIVFVAASFAQSYDDVSAEKRAMRNALVRFGRASGGMRNALVRFGKRSPLDEEDFAPESPLQGKRNGAPQPFVRFGRSGQLDHMHDLLSTLQKLKFANNK
The following text describes a protein:
Function:
Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (By similarity). Required for SRC-induced podosome formation. Involved in positive regulation of immature dendritic cell migration.
Subcellular Localization:
Nucleus. Cytoplasm. Cell projection, podosome.
Domain:
The PH domain binds to phosphoinositides and is essential for podosome formation.
Sequence:
MEAEEPEYGVSTEVPDIEELKTIPEGIMRSSQIPALDPEAQEDRDPSYKWTDGHRPVMNQSKVLRDMGDHTPNSMAIFFKKESSDMETSQEILLAEACNTPDQQEAVIQSLKDRLSRTIAAPELLACAVQEEWLDIPSKLDNRVGAELQSELMSLTLAVSKEKEEEETSPDTSIPRGSWPPCKTHPGETEQTQGSGSELLRQGKQLQLEATQENQGQEGFLQSQEAQGLEEQEGQEVEIQEEGTLNEGICFGGLLGEQEEVEEGFNGNEEEQKQGQIQSYMLLGGQWENEGLSGELEGLNYSERGQENRERRVWVLRDSEEEGQDQESREVEERRVATQYTENQRLVEKSEIVKRKQRDHDQTGKVMPVRDQKEVVDSGDRVQGNGDSGGQTAVEGSRPGEDSKPSLPVASVDPEVLSPGTLFPGISSSVADIPQIQKEPVCEELSPQAPALEPTEWSHQPISPPASFAPEESLDNRTHNSQQEEFRLRKGIEVVSASTSVAPSGTRDSPPFSPPNVFSSTATLSPVSSSVILPEETPTASASADTPHHCGPCETPPLPAKSSRYPCATSDTANPHSPLSSYTGVTQHLRSNSFPGSHRTEQTPDSLGMSLSFSHLELPQRPPKPAIYGSLTPRRNRRSRDGIVFSDSSTALFALKQDSEEFTSNPERPSSPHGSPTWGSPQNSAFAIGSPANVSSPPTVSMDMTIREALLPIPPEKRHSYSHIVERDGLLHEVASTLKRHSHPPPLTLSSGLHRSSKGSFSLVPDSTVARQHRPLPSTPESPNHTQTSIPSRLRYNKPLPPTPDMPEFYHPSISSSYISRMYRPLPPVPIIDPSSEPPPLPPKSRGRSKSIQGGVIHSGGQAKPRPNNQDWTASTLSVGRTSWPPATGRSTESLPLTSRCNNEVSPGLAFSNMTNLLSPSSPTTPWIPDLQRPTTKDESGLTEESEPPVRGSFRRSAPQEEFNNTRRSALGSRKNSEKPLHHQLEKASSWPHRRDPARTSESSSEQVVLGQVPNKQKGWNRQGLRRPSILPESSSDLRNPAAGRLPGSSDSVVFREKKPKEGMGGFSRRCSKLISSQLLYQEYSDVVLNKEIQSQQRLDSLAEPHGLSSPRHRRKALVSSDSYLQRLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEAKFELIVSEASYLRSLNIAVDHFQHSAQLRGTLSNQDHQWLFSRLQDVRDVSTTFLSDLEENFENNIFSFQVCDVVLNHAADFHRVYLPYVTNQTYQERTFQSLMNSNSSFREVLEKLESDPICQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALEKLIRDCNSNVQRMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGELTALEFSVSPGLRRKLTTRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSIRGEKCEMKLHGPHKNLFRLFLLHNAQGTQVEFLFRTETQSEKLRWISALAMPREELDLLECYDSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGEQGWFPVQQVEFISNPEVRAQNLKEAHRVKTAKLQLVEQQV
The following text describes a protein:
Function:
Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MFPSCYLKPADSGGKTSALAKLLLGVFVVYALHTAWLLYGFLNSKPCDRSRGELCMASYLHNRPRLQLSVFTCLVPEDSQLHPILRVEAFDPLSTFERQVNVSLPEETRANGTLYAVVYLHKVGVSPLEDRKEVHYAAQLTTYMNPANKEDQKDPQKVGSVRPVSHWTPLLSITMMSEDFSFSKAGLPSDVRRYMRVFQEGRQMIYLPLLLVNELSSRVKDLKEIGSSSVQLPLTISYEGISLRKFRFWIHLHDIVYSLRQFGFSEENIDEIKETLVGSNLYLLVLTALVTALQVGLICEFLALKNDICSWREKKSMAGISRKSVLWRCLCTLLIFLHLLEETSLLVLLPVGLGACVEVVHASRYLSYLVYPLCISGAVFSLVYLRKRNYYSWLINSLVTGVYAFGFLSMAPQLFINHKVRPTRRQNKVLTSGKIWKCITYACSFAFFFSSTASFSSSHQLSCFRDEVLFFLYLYQRRY
The following text describes a protein:
Function:
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Sequence:
MATAPVKFSVATNSPCVQPSLPLRRTPAAISFPCRPWSAAMNSCTGLLRRSDVVAAAGHQKLMGSLTTNEGLRFGVVVARFNEVVTNLLLQGALETFERYSVKEENITVVSVPGSFEVPITAQKLGKSGKFDAILCIGAVIRGDTTHYDAVANSAASGVLNAGLSAGVPCVFGVLTCEDMDQALNRAGGKAGNKGAEAALTAIEMASLFRHHLG
The following text describes a protein:
Function:
Envelope glycoprotein that binds to the host cell entry receptor NECTIN1, promoting the virus entry into host cells. In contrast, does not use host TNFRSF14 as receptor. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity).
Subcellular Localization:
Virion membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs.
Sequence:
MLLAALLAALVARTTLGADVDAVPAPTFPPPAYPYTESWQLTLTTVPSPFVGPADVYHTRPLEDPCGVVALISDPQVDRLLNEAVAHRRPTYRAHVAWYRIADGCAHLLYFIEYADCDPRQVFGRCRRRTTPMWWTPSADYMFPTEDELGLLMVAPGRFNEGQYRRLVSVDGVNILTDFMVALPEGQECPFARVDQHRTYKFGACWSDDSFKRGVDVMRFLTPFYQQPPHREVVNYWYRKNGRTLPRAHAAATPYAIDPARPSAGSPRPRPRPRPRPRPKPEPAPATPAPPDRLPEPATRDHAAGGRPTPRPPRPETPHRPFAPPAVVPSGWPQPAEPFQPRTPAAPGVSRHRSVIVGTGTAMGALLVGVCVYIFFRLRGAKGYRLLGGPADADELKAQPGP
The following text describes a protein:
Function:
A cell adhesion protein that binds immature cells of the granulocyte lineage.
Subcellular Localization:
Secreted.
Sequence:
LVLLLSLAQLWSCHLVTAVPLLGYREHNCDDPEAEQVALLAVDHINNHLQQGYKHILNRIDKVKVWPRRPTGEVYELEIDTLETTCHALDPTPLANCSVRQVTQHAVEGDCDFHVLKQDGQFTVLSAKCDSTPDSAEDILKLCPDCPLLTPLNDTRVAQAAEAALTAFNEKNNGAYLQLVEIARAQLVPLPASTYVEFTVAATDCVAKEVTDPAKCNLLADKQYGFCKATVAEKVAREEVEVTCTIFPAQPVVPQPQPGVAGAAAVEPAPAVDPASPVSPPDGQSPSSLVVGPVLVAQAPAPPRAHYDLRQTFAGVPSMESGSGEAFHPGKVPVVVQPSVGAAPGPVITPCPGKVRYFKI
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular Localization:
Cytoplasm.
Sequence:
MGAYKYLEELQRKKQSDVMRFLYRVRCWEYRQKNVIHRASRPSRPDKARRLGYKAKQGFVIYRIRVRRGGRKRPVPKGATYGKPTNQGVNQLKYQKSLRSTAEERVGRRASNLRVLNSYWVNQDSTYKYFEVILVDPSHKAIRRDARYNWIVNPVHKHREARGLTSAGKKSRGINKGHLFNKTKAGRRHTWKKHNTLSLWRYRS
The following text describes a protein:
Function:
Has a role in fat regulation independent of daf-16. Implicated in ciliar sensory function which is required for normal sensory behavior such as chemotaxis. Required for extension and growth of sensory neuronal cilia during postembryonic development, potentially via mediating signaling protein transport and localization of PI(4,5)P2 to the ciliary base. Functions in life span control via the insulin/IGF-1 pathway. Thought to be involved in neuronal trafficking.
Subcellular Localization:
Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell projection, cilium. Note=Expressed in the periciliary membrane compartment in AWB and ASK sensory neurons.
Sequence:
MTDTNSQWIEMNLQRQRKMLEDKQKQKRHQSAGSVRTTSTAMSMNSMKDYPTFDNSLPFSISDNSSVSVSMNTPLIPTQDPIAQPRMQSMPRQQPQQVQESLISIGDYPDNDINAKLSKVNLTSCVVSDDEDEDKRSYADSPWNTDVVADRIPSEVLPDYNFIKNNLAKFVEDPAVEHCLYKCSITRQKSGVDKGMFPTYFLHLEEFDTDKRQKIFLLAARKRKKSTTANYLLSTDPTNLSREGEGYCAKVRSNALGTQFTVYDSGQNPKKTTNHAAIRQELAAVIYETNVLGFKGPRKMTIVMPGIEPPTENRPAVRCPVRPIQDKHTLLERYRLNDLDSLKILSNKSPQWNDETQSYVLNFHGRVTQASVKNFQIIHQSSPEYIVMQFGRISDDEFTMDFRYPLSAVQAFGIAMTSFHGKLACE