lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state. RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSAGDSIQLFPPTTKQAIEASFVPHGKISPLIKRAVEPVGPLFLAHARRQRHGRTFSEDERLEVKNKVQEEVKEESEDEEEDPAMLRADPKEWKQQDHYAVLGLSKYRYKADTEQIKKAHLKKVLKHHPDKKAASGNINDDSFFKCIQKAYEILSDPVRRRQFDSVDENADVEPPESTTKETFFELWTPVFESEARFSKKQPVPSLGTIESTRAEVDNFYNFWYNFDSWRSFEYLDKDIPDDGESRDNKRFQEKKNRSERQKNKARDNARLRNLVDTALASDPRIKLFKEQEKAAKAARKWEREAGAREAAAAAQKKKEEEERRAAEEAAAKASAAAANKKAKEDKKKAQKRDKKVVKNALKDFNYFSATDVPSAEHVDSVLKDVDVIMSKLGEGELGQLAADINAEKAAGAASVQAVFDKFAKMFIERGSMSSADVVFFAQ
The following text describes a protein:
Function:
Component of the PI(3,5)P2 regulatory complex that regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Directly involved in vacuolar membrane scission. Required for normal vacuole acidification, inheritance and morphology (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Vacuole membrane; Single-pass type II membrane protein.
Sequence:
MSEPKPMQMSVETETVLNVSQVQIPSSCDRKASLETLKTKKNAQKKKKISLPNVMTSKAAMFAARVASAVDQDPNDEESENFVYENLIPTNDDELHSPSASIHSFQTYNLPLEMLPTINHVPYYGSAGTNALNGGPLSNSRKLIPKRSAKFSSMVGSSDTRCNSPTTARGLATSPLQINPTTSKSPLLNKKLSSTSQEPFRTSRRSGQESGDVTTKMLRNLLHKRLWISFFFACFVVLSLVYFHYAVQPLL
The following text describes a protein:
Function:
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
Subcellular Localization:
Cell membrane; Single-pass membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Single-pass membrane protein; Cytoplasmic side. Cytoplasm. Note=At the interface between the lamellipodial actin meshwork and the membrane.
Sequence:
MSRSVLQPSQQKLAEKLTILNDRGVGMLTRLYNIKKACGDPKAKPSYLIDKNLESAVKFIVRKFPAVETRNNNQQLAQLQKEKSEILKNLALYYFTFVDVMEFKDHVCDLLNTIDVCQVFFDITVNFDLTKNYLDLTVTYTTLMILLSRIEERKAIIGLYNYAHEMTHGASDREYPRLGQMIVDYENPLKKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDTMPCEYLSLDAMEKWIIFGFILCHGMLNTEATALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNKRINDIRECKEAAVSHAGSMHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIWLLRHADNMPKKSADDFIDKHIAELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLSLADHRELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSIAFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMAVWEHTFTPREYLTSHLEIRFTKSIVGMTMYNQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDISEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQMRTSFDKPDQMAALFKRLSSVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSSAAGLPCEIDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTIHKGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIVQESPFLTMDLLESCFPYVLLRNAYHAVYKQSVTSSA
The following text describes a protein:
Function:
Growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor.
Subcellular Localization:
Secreted.
Sequence:
MAVGKFLLGSLLLLSLQLGQGWGPDARGVPVADGEFSSEQVAKAGGTWLGTHRPLARLRRAPSGPCQLWSLTLSVAELGLGYASEEKVIFRYCAGSCPRGARTQHGLALARLQGQGRAHGGPCCRPTRYTDVAFLDDRHRWQQLPQLSAAACGCGG
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MDDFLELISTNYVQGMKKAKRILSNNSDDFDKYNGEMKEKASFNRCLVNNNDTNIFVTCKECCLLPVDIFCLKCFQHEKHIGHHVSILRSTQAVCDCGNPNAIREEGWCDKHHNYMNDQRLTPERVSEISKIVKSLLLYSIDICGENRFRKIIKLIEDLSLWGVEYMDIVSQLLFEGDFENSIFGKLMNSYSVFPPQNTEKLDHFFNTIVTSMPFKEGYQRMTPDLLKRSLKFFTDQPNFLKESLDVLSFSTQCMSEPDNFYQIPEFFEILYDCYAKSIGYCLVHEPIVHFRSLDDFDTIGHFYEITLQVLKNHKFIQYKFMNDPTVTIDKIISIFSQLNGVPSIVRQYNEKEPFDNDYYTLSFHFHETGSEMFTFISQRFSEIYNKLTSKEDLEKAKDSVSLILGEFKKAFIDQIETKSTMFDCETFFKDIYHEQFSFFYPVYDLFCQCIMRYSKKNNVSPYYVLENAHFSETDILKVNSVICGCTAGIFAVFCKLFQKNVNNISIISSLIQNSNVIWTDLLLCSLISKENKYLTDKFICQISESFCLQKFLNETEYVEELSLLMASLIRIILILSFYRDWSMFELSKAEWQKAILKCFLKSGCKNRKEINNKSYMFMQAENYDDVISSVADIQRKPTGSELSLKNEKEVPLFSPYITFSDYQLLISKENENLCYLPLQNCEPYLVLSDNYYHLLSYLLDSIAKDDRKQSFVLFYSILMSFRIILHFAEDKMKYKNLVISLMHEPEKTSTGQDLFENFLKENPIFADIKNVKTEKSEETKGVSIKDIMKQFQTENLFDGEDSDEEEEQNEVKCAFCGMAIRNFEPKCLLVTAYNSNLLTVLENNISGYSLPRFPEFMIFRTCGHFCHEICYPKSEIDDVPLILRMYAAKPKPPTCPLDRSICNSKIPIINSEEDQTERVLKFETELQLPDDITLRQNVLQNICLFEILLRTNENYLEKKQTIRLMFSNLLRICFHSKDEEIIYSDVFIQFGMKLFSMKVEDYENILKEFWPKFVTNSLEAGGSDYLMTYIRRCHLLYNLIDENNKFTMPKSVEEFIELHKLPKVENVSKNDDLLVASVPSPCKKFNSSFLPSNFTDYFTQNDKGFTKNLCRTDISVSQCLLCGKFVYSIPIGSSLAKQVKGLEFLRDHIMNCNHGAATPFLHITGSNASGVDVVDHQFITKYDHGSIYVDNFGDTDIGLLRGSILHLEKDLFEEIIEQTMNSELRRLVEEKEPTTLEELQQQQLIRIEINNV
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular Localization:
Nucleus.
Sequence:
MASTAVASNSAQRLPLAATGRPNQHFELGVKGRKTGWAQTKQVRKDADGLDNVDDFFQSDDEDNINVASRPPSNVKDNQGNQHLGQYNQDLQEPESQELEEDSRFFDESFAEPQSPTSDKNRNIHQEHLQVSVSESRQHQRLVMESPITPTVNQHSASANKRTGRFLQSVDSFDTTLNGPLDDEGVAQYDTSIQKPLPVKHVVMADQPQQQGSISHTPVQFVSRPKIARTPQGVVYSESMYPQNVTRSAPRQSMDGREYRYQNGRQLVSTSRKSITPQQLVKPSMSIGSAKAMSSRRPQQHFRQGGPTLVSKPIKYDHDEYDQSMEYRTRGRLSHAMTETAAGRMVRVNTSRQTNNDTRGYLDEQDMLDPYLTHNQADLVANSRAIRPPARRHIPPAAEYYNEQDEDNIYYTDDPRAEINPQTGSRRIGMSAHQYTNVNQFQQPFVQRRAVMMDESDMHDNPRPMKRQRSAQPQQQFSPDYHDEYKKPHAHVERRREIMYASPAHIRQGQTVQHLIRPQQKGRQTISSARTSTKVAEFSSVKDEDLPCESPLKNWSENAHDKPTYTESNSNVYYDDNIPDTYPESDGENEAENFHDSAIVRDNPVVSGSLSKVQKQHSTKQAHSSHSLKPSDREYDQVEYAQASHSPIDVQRRPPTQGNGRKKGAQRLIIRELDPEEEEENQRNSSVVQPEHAEDSGEDGQVDVNESDMREQPLPDTARDLEVSLPPRNPRGRPPKSRGIVPKQKHIAVHQELDSLDHRTNQGQLVVKQRSVPIKKSIAVVSASIKQEGEEVEIETDGARRSRRTKVQPVAYWKNERVIYGRRVSGFGGVPTSVKEVIRIPSDDETIAHRRSRAEKIKKEETEAVPSEVSVFNYRTGQEELHNIVVTPGMIVPRTVGAGDYRFQKVFSEGDFLASGVLALPRGAKKPIRGSGDSAMIFLLLSGQVQVRVNETSFVISHGSQFFVPRGNLYEIENIANREARLFFCHGKEVLQSST
The following text describes a protein:
Function:
Formins play an important role in the nucleation of actin and the formation of linear actin filaments.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Note=Found localized to the crowns, which are macropinocytotic cups rich in F-actin.
Domain:
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Sequence:
MKIRVELINGNEHRTSSTPQQPQQNPSVSHIFDGETAVKDHIKVLLTHFKIPVDKVSSYALQNPFTLAYVEDSFLTPERLVEAEKSYFILRMKPHAIADRVVDQLTKIEPTSPHIKDTIFNIRYQMKDVEYVEEFIIKGGINQLLAVIIKSRGNTQSYALTALRCFMGYNSGLEEVMSRPQLIDKLYSLVCSVGVLPSVCRQAIELLFCVCNFDGFQLVHRSAKNHAQETSTPAYSNLITLLSSGDMETQLNTLTLFNCLLDNAPNPRKSEKLLSRWQQLGIIKILKSQEHVTHSDFRTQIARFQANSGFGIDGSGRKRTLTRQLSTQELEFQLHQFREQQPLISLLTSELKFLRNAIKSAIENGSYINYRAPTERYDEYSQRKLEMIGDSPTNLQFLKRNDKFTNAFRKSMYVRSPNTSDLFDSSTLEDTYDGNNDTNSCTSISTSSTPIHISQPTTLIVPSTTPNHPPQQSQQTPPLQLQKEKEKEKEKEKEKEKEKEKEQQQQQQQSNKQSTPKPNLSCLLSPITISNTLNNNNNNNNNTNNNIIKSNNNNNNNNCTIKDLSPIVKSEKSNEDEIHEISLNGASSNHEEPIKYKLQPTKSPITPSKRMKPLHWTRILNSQFEGKKTIWNSYLPEVTFEEELFVDLFSLYTERIVSFSGSPVGSGTSISGGGPIKSKPIQKVISVLSQKRSNAIIVMCGKLPSDDILIRAIRNLDSNKLSLDGVSSIISNFPTSEELASIHELHSNEVILDKPERWCLMIDGFPMIKHRLRCWEFMLKIEDSLKSIIESIDTVLLACKELRTSITINCLFSLLLQLGNYLNGGHLYRGQSDGFNLESLSKMIEIKDNSNSGSLLDFAIKTLYQQSPMKGNSNTSIHLELAHVPNASLINFTDVGTSVSKLLQDYSEIVLMSDEIQQTTDKDDPFLDIVPKFMGTILLILKNLQTKFLETEKYLFETIDYFNPTNQTLQQYQQQQYQQYQQQQFQQNIINNNNNNNNNNSNNNNNNISGNTTTTTTTTTTTTTGSIINNNNNNNNNNNNSNNNIINNNNSQSNLQSLLHPQYYLSNSSSSSSSSYKITPPLSSSLSITSQEWNQQKFTCEKFFTLFSTITTAFKKSPSKRLSQKGFGLKISNSDDPMAVIIEALKTGSPNDMVKRAF
The following text describes a protein:
Function:
May be involved in pectin biosynthesis.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKGGGGGGGGGGGGKRRWKVLVIGVLVLVILSMLVPLAFLLGLHNGFHSPGFVTVQPASSFESFTRINATKHTQRDVSERVDEVLQKINPVLPKKSDINVGSRDVNATSGTDSKKRGLPVSPTVVANPSPANKTKSEASYTGVQRKIVSGDETWRTCEVKYGSYCLWREENKEPMKDAKVKQMKDQLFVARAYYPSIAKMPSQSKLTRDMKQNIQEFERILSESSQDADLPPQVDKKLQKMEAVIAKAKSFPVDCNNVDKKLRQILDLTEDEASFHMKQSVFLYQLAVQTMPKSLHCLSMRLTVEHFKSDSLEDPISEKFSDPSLLHFVIISDNILASSVVINSTVVHARDSKNFVFHVLTDEQNYFAMKQWFIRNPCKQSTVQVLNIEKLELDDSDMKLSLSAEFRVSFPSGDLLASQQNRTHYLSLFSQSHYLLPKLFDKLEKVVILDDDVVVQRDLSPLWDLDMEGKVNGAVKSCTVRLGQLRSLKRGNFDTNACLWMSGLNVVDLARWRALGVSETYQKYYKEMSSGDESSEAIALQASLLTFQDQVYALDDKWALSGLGYDYYINAQAIKNAAILHYNGNMKPWLELGIPNYKNYWRRHLSREDRFLSDCNVNP
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Sequence:
MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNSQNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKSYLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNGVMFYDHIDKENPFKEPENAIAIER
The following text describes a protein:
Function:
May promote cell proliferation and inhibition of apoptosis of preadipocytes.
Subcellular Localization:
Nucleus.
Sequence:
MTTATRQEVLGLYRSIFRLARKWQATSGQMEDTIKEKQYILNEARTLFRKNKNLTDTDLIKQCIDECTARIEIGLHYKIPYPRPIHLPPMGLTPLRGRGLRSQEKLRKLSKPVYLRSHDEVS
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKVLEARDAYLTNAEVFFHLKEMENEQNARTQERGAAQALVCENLRTIQFEILKYLSSQGNCEGLTKERFLDCIAIFNEFELTKAEILVILNNKPSSVPELYACIEGIEERFKEEDIFKLVEKINTTFP
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MEYSSTRVVCLALALAMVAVTPCAAQNSPQDFVNPHNAARAAVGVGPVSWDENVAAFARSYAAQRQGDCKLVHSGGGPNHYGENIFWGGGSAWKASDAVGLWVGEKQNYDYNSNSCAAGKVCGHYTQVVWRKSTAIGCARVVCNNGGGVFITCNYNPPGNFRGQRPY
The following text describes a protein:
Function:
Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
Miscellaneous:
MISCELLANEOUS: NAD is bound in an unusual conformation, at the interface of a dimer of the enzyme.
Subcellular Localization:
Cytoplasm.
Sequence:
MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL
The following text describes a protein:
Function:
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
Sequence:
MDLTERHKRILKALVDEFIQENRPVGSKTLFDKHDIGLSPASIRTVLKDLEDFGYLASKHTSGGRIPTERGYRFYVDSLVILYELTLKEKQRIQQEYLKMQFKLDQILKATASVLSSLSNAAGIVIGPAKNLDTLKHIELIHVRGDEILMILVMRSGTVLHRNIFVDQNYSQEALYQVSKYLNDNLKGYDIYEIQNVIIPKLMIRKDGPEDFIRIADLISSAMTPDNSEVTLYIDGFKNLYANFRDEEQQLSQVLSLLDDQGFLKAFFSEYIDQDGVFTIIGKDGDRSMSGVSIITSNYKMGEKKIGALGIIGPQRMDYNRALPLVDFTSKLVSEMVTRISK
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MLVARERKYCSVCHQLGDGYHFGAIACKACAAFFRRTTSMNLAPKFVCRKKNECVIKMSSRDSCKSCRYAKCLHVGMNPEVVQAIQQAAKQANSPGIESLPSCSSSPASCNSPILSLELGDYDQMTPTLCGVMESYQKLYKKRYDLHAPKLTPRATNYGEFCKIYSNDVYLQFEFLEGSFPQFKEMGGFEKKHVFKYFFVSFLILEMGYRSYQEGTDAIVLANGDFIDTMNLDEFYYDPESLEKCKPTDAMKMYRPNFDQMKRNVFQPLSHQKLSLIEFLALVSLCTWNESLDGQPDCYYPSCRPVRQSVIADLKAFYEKDSPDVDPAYRLSGLLMLLPALERSVELFLQTMEVKRLFRCFPFHDKIYKIIDGQ
The following text describes a protein:
Function:
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
Subcellular Localization:
Cytoplasm.
Sequence:
MEFDLKGKRVLVLGLGESGISTTKFLKEEGAKVIVNDYKEEEDFKNLLDFFRNNDILYIFGGHPIEILRNIDLVVISPGIPKTNPIYIEAKKRDIKVISEIELAYWYAKVPIIAITGTKGKSTTTTLIGEILKNAGIPNIVAGNIGLPFISVVKDLKEGYFVLEVSSFQLEDIEKFRPFISLFINIYPDHLDRYSSMDEYMLAKSRIFMNQKEEDYAILSYDQEEIINLAKPYKVKKLFFGFKKHENDGIFYDESRNKVFYKLSERYGSLTIPKGIWNRILISNFMASALVGLLLGVEERVIEKTGEDFQGIPFALQRIGELNGRVFVNDSKATNPVSTSSAINSINSPIILILGGRNKNFDFHELFENIKKSKVRRVVLIGETKEIMRELSEEYEIPYVIADSLEDAVRRAYEVSEPGDVILLSPACASFDMFRNYKERGKIFNDVFERMKNEKV
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MVNMASVEGIVDCLLQGQLETAMDNIHDILTQPEEVNGIKEFSILIQEAARQEEIHRSHIKDVLKAYMSMKDNMESVIAEDKSADAIGEEINLLQTQHQKALQTSEAAKEQCQALNEEREKMHAEQEALSQKRETVKEDTTQVLPKTRYNVSLYSCITGIKWDYDCKPDEIKGYVSTSKDVRPFSLDCKQHSKFFTTNYLWDLVEAAVEAK
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion.
Sequence:
MAEERKTVTLPDTDNTSLTCAARILAHECADANLEFMRCKQRDANPRACLVQGEKVTAAVLKTLREVETNCGETYAAYKQALKKSWHRIDETRKEQAALEQCWRQHKGYNQEQADN
The following text describes a protein:
Function:
Possible transcriptional activator.
Subcellular Localization:
Nucleus.
Sequence:
MNTFGQQPTNPHAQDLLDMAMYCDHFSLYHQQQNQQLPQRPAAPPATGYGLNEYSSPPSSPYLWLNGPAINSSPYLNGGSGSPYFPAGYGGGQRQFLPPSSGFGVADFPWLSIPNQADLLKMVRPPYSYSSLIAMAIQNTPDKKLTLSQIYNYVAENFPFYKKSKAGWQNSIRHNLSLNDCFKKVARDDHDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSESVGAGFDEDSNEDKKPLALKSLGSDSPQGASVLEQSSYDAAPEGKSKAPVGSAAQDSSHCFTNFASNMNALINNRTPRQFTAGRGDFSNSRHYLAELTSCPIPSPQISAPQTGSKVPCYPSKQQNNLCTSVMNPFGLNHLYSREGEV
The following text describes a protein:
Function:
Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MWKSILAIALGAALGALLRWFLGLKLNSLLPSIPPGTLLANLVGGYVIGAAIAYFAQAPGIAPEWRLLIITGFCGGLTTFSTFSAEVVSLLQEGRLGWAAGAIATHVSGSLLMTLLGLFSMNWMLGK
The following text describes a protein:
Function:
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAQVDSQDRWGEASPLSSLTEEAHDTQMLSMNLESDDEDGGEAEKEGTADPVACPRGSSPVTRENPDLPWPHPLGKEEEKFSDSSSAGGMGQKPVEMSGKASWSRDVTKIKETQGSPGASRALGTLPSGLAHKLLGQMQPLGDRLPAGDDGDSRANQDAVLDVPSSFPSNGKYLCAHKSVDTSAGNSSLLCFPRPGSNWDLPTQETHTPAQASATPASLAAAVLAKARNSRKVQNQAGRREGGEAEARPYRCLRGGRAFQKPSKPLSPAETRGGAAKRYACELCGKAYSHRGTLQQHRRLHTGERPYQCSFCDKAYTWSSDHRKHIRTHTGEKPYPCPDCGKAFVRSSDLRKHQRNMHSNNKPFPCSECGLTFNKPLSLLRHQRTHLGAKPFRCPACDREFAVASRMVEHQRVHSGERPFPCPTCGKCFTKSSNLSEHQTLHTGQRPFKCADCGVAFAQPSRLVRHQRIHTGERPFPCTQCGQAFARSSTLKRHQQIHSGEKGFLCAECGRAFRIASELAQHIRMHNGERPYQCEDCGQAFTRSNHLQRHRAKHGTCKKEPIPSSSDE
The following text describes a protein:
Function:
Plays a critical role for male fertility and sperm motility by regulating sperm cytoplasm removal and maintaining axoneme integrity.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNMPVNKSPMINTCGGISSPYHEELWKLNFQHLSGERGHKSRPTFSITKEFILRFNQTQNSKEKEELLELARKIILRCKRKLGLKTLGSGRHVHLPAAWTEVIYLAQCKGEIQDESLNMLYASLDHASFDYDHLPALFFVAESVLYRLCCDASLKTYLYSVEIKLAKIGYLVFLRLFIFFLHGHLESFKQHLLRLQPYLYALSFSGASYHKYPNIFSNVQFILKASEIIGKRELRSESIFRPVEDKKRYENTDSDMGGYEINHLLWHCVAAWSCVQNNSPQLNNVLEHLVFHKTQLQKKCWLDSVLALLVLGEAAKLNMACLKALMDVVRDFVSSIMSVQNQEESCKVDDFSWAWNVVYIYTVILAEICLYAATSDLRKTALIGFCHCKSSQKNILYLDKSVPPELKETSILSLLEYFSSKMSENCDQVVWTGYYGLVYNLVKISWELQGDEEQDGLRNMIWQTLQKTKDYEEDVRIQNAINIAQAELNDPTDPFTRYSTNISSNVGEEVFSKYIGWRIANTLSKLFFPPIEAHFLPLKKPSIKKDQTKYPNKKLESVKKQVLHFTVREHPSVSEIPMFPYPDFFTKADKELAKIIDHHWQEELKIREKEDAICKAQELKDKKLAEKNHFQEVMKKREEKLHKQTKPYELPYRKEVI
The following text describes a protein:
Function:
Required in hedgehog (hh) expressing cells for production of appropriate signaling activity in embryos and in the imaginal precursors of adult tissues. Acts within the secretory pathway to catalyze N-terminal palmitoylation of Hh; this lipid modification is required for the embryonic and larval patterning activities of the Hh signal. Not required for Wg signaling.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSRLPDRSLLTRCEIFVYFGVYIAYIVVGLYKIYGLRDHIVKEAKFQFPEGWSLYPFSQRRRDDSNDELENFGDFIVSFWPFYLLHVAVQGFIRWKRPRLQCLGFIGVCALALSVNLDWSSMVLLVTLIASYYIVSLLSLKFLVWLLSAGWILCINVMQKNVWWTDRVGYTEYVLVIVTMSWSVLRGCSYSLSKIGAKQEDLTRYSLVQYLGYAMYFPCLTYGPIISYQRFAARREDEVQNWLGFVGGVLRSAIWWLVMQCALHYFYIHYMSRDVRMVEMMDSVFWQHSAGYFMGQFFFLYYVVTYGLGIAFAVQDGIPAPNRPRCIGRIHFYSDMWKYFDEGLYEFLFQNIYAELCGKRSSAAAKFGATALTFAFVFVWHGCYTYVLIWSILNFLCLAAEKVFKTFTAMPEYQRWTQRHLGAVGAQRLYAMLATQLFIPAAFSNVYFIGGQEIGDFLMRGAYLSGVGNYVALCFCSYCFFQCSELLLTKSDGRSKTKTF
The following text describes a protein:
Function:
Ferric chelate reductase probably involved in iron reduction in shoots. May participate in the transport of electrons to a Fe(3+) ion via FAD and heme intermediates. May act in iron metabolism in reproductive organs. May function as root surface cupric chelate reductase and participate in the reduction of Cu(2+), for Cu(+) acquisition via Cu(+) transporters in response to copper deficiency.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGNMRSLVKMLMVVLFLGWIFVWIMISTNRFQNIWTPKLAKYLKTTYFGPQGMNLVLLTVPMMFIAVLSCVYLHTQKQPSQTQSLYKCREWKVKGRMGRVMMVMNPLGIVTATELTFSLLFLALLVWALSNYLYLSYHVHLHNHDNANDMCRWQAKFRAFGLRIGYVGHYCWAFLFFPVTRASTILPLVGLTSESSIKYHIWLGHVSNFCFLVHTVVFLIYWAMVNKLMETFAWNATYVPNLAGTIAMVIGIAIWVTSLPSFRRKKFEIFFYTHHLYGLYIVFYAIHVGDSWFCMILPNIFLFFIDRYLRFLQSTKRSRLVSAKILPSDNLELTFAKTSGLHYTPTSILFLHVPSISKLQWHPFTITSSSNLEKDTLSVVIRKQGSWTQKLYTHLSSSIDSLEVSTEGPYGPNSFDVSRHDSLILVGGGSGVTPFISVIRELIFQSQNRSTKLPNVLLVCAFKNYHDLAFLDLIFPSDISVSDISKLNLRIEAYITREDKKPETTDDHKLLQTKWFKPQPLDSPISPVLGPNNFLWLGVVILSSFVMFLLLIGIVTRYYIYPVDHNTGSIYNFTYRVLWVMFLGCVCIFISSSIIFLWRKKENKEGDKDSKKQVQSVEFQTPTSSPGSWFHGHERELESVPYQSIVQATSVHFGSKPNLKKILFEAEGSEDVGVMVCGPKKMRHEVAKICSSGLAKNLHFEAISFNW
The following text describes a protein:
Function:
Probable actin-based motor with a protein kinase activity (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, stereocilium.
Sequence:
MMLGLESLPDPMETWEIIETIGKGTYGKVYKVANKRDGSLAAVKVLDPVSDMDEEIEAEYNILQFLPSHPNVVKFYGMFYKADRCVGGQLWLVLELCNGGSVTELVKGLLRCGKRLDEAVISYILYGALLGLQHLHCHRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFEMHPVKMLFKIPRNPPPTLLHPDSWCEEFNHFISQCLIKDFEKRPSVTHLLDHPFIKGTQGKVLCLQKQLAKVLQDQKHRNPVAKTRHERMHTGRPHRVEDAGKCCLEDDLVNLEVLDEDTIIYWLQKRYADALIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRSSNPPHIFASADNAYQCLVTFSKDQCIVISGESGSGKTESAHLIVQHLTFLGKADNQTLRQKILQVNSLVEAFGNARTAINDNSSRFGKYLEMMFTPTGAVMGARISEYLLEKSRVIQQAAGEKNFHIFYYIYAGLYHQKKLAEFRLPEEKPPRYIAGETERVMQDITSKESYRTQFEAIQHCFKIIGFADKEVHSVYRILAGILNIGSIEFAAISSQHQTDKSEVPNPEALENAACVLCISSEELQEALTSHCVVTRGETIVRANTVDRAEDVRDAMSKALYGRLFSWIVNRINTLLQPDKNICSAEDRMNVGILDIFGFEDFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYKNEGVDAVLVQYEDNRPLLDMFLQKPLGLLALLDEESRFPQGTDQTLVDKFEDNLRCKFFWRPKGVELCFGIQHYAGPVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRAKITASSRSLPPHFSAGRAKVDTLEVIRHPEETTNMKRQTMASYFRYSLMDLLSKMVVGQPHFIRCIKPNDDRKALQFSQDRVLAQLRSTGILETVSIRRQGYSHRIFFEEFVKRYYYLAFRAHQTPPANKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVMGRVVMLQAYTKGWLGARRYKRAKEKREKGAITIQSAWRGYDARRKLKQRSRRRSESEAHIHTVLQTTPDQKYCPDSGGESNRGHEETSRNCPAEADTDGHPQAQSPPTGCDVTSGHADTAAGYTVAELSVAGTDVSPSLVYHTASAHQRLSPCEDSLKPGSEEGLSQKQRAPRRRCQQPKMLSSPEDTMYYNQLNGTLEYQGSQRKPRKLGQIKVLDGEDQYYKCLSPGACAPEETHSVHPFFFSSSPREDPFAQH
The following text describes a protein:
Function:
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MAAPSCRGPRAEPEMGEGGGGAESFARWRRPGAENGGRTRKWSVGRADGGEDADSFGRWRRPGAESGGRKRSAGTFDGTDGADALPRWRRPRAEAEVDGPGGAGTPPPSPGDIPSCPAAALARKMAAPWWRPLRLLRPRRAATEAGRRRAGGGRGLLAEQRERGVFQEIFPARGSDEELSELLARRQVVYCGFDPTADSLHVGHLPAVLALLRCRRAGHDVIALVGGATARLGDPSGRALERPALGAARVRENARALGRGLRALAANERRARAAGAGPGGGRFAVLDNAAWHGGRPLVDFLEAAGGAFRVGPLLSRHSVRARLRSPDGLSLAEFCYQVLQAYDFYHLHRRYGCRVQLGGHDQLGNIQSGYEFVRKVTGKDVFGITVPLITSTTGAKLGKSAGNAVWLNRDKTSPFELYQFFVRQQDDCVERYLKLFTFLPLPEIDHIMKMHAKEPEKRGPQKRLAAEVTKFVHGPEGLESAKRCTQAIYHSSVDVLETMSDQELKELFREAPFSELVLDPGTSVIDTCRKANAIPEGPRGYRMITDGGVSINHHQMTDPESVLVLGQHILRNGLSLLKGYGGSRDLFNATAAFISSTGKTGEGHQLLDRSGSSPGSNDTISGMTRAFQRATCELPKLRFTAPVLRNTTEPTGLRTARSVAYRGVVFHTAKPEPRTTNVHAGPEEESEQTLPSGSAEAAAASSGEADPIVPGALEDERRQEMQGKKKPRLRYYSTFYSPSHLPVVGIWNG