lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSSGPDTELAYPDCTFHTEVLPCESHSSVSFQEAGPSRYTANAEPYTKAKPVISSPVTRNSLDKAASHLRASQLVAFPSETVYGLGANALSQSAASKIYAAKKRPADNPLIVHVSDLEMLDTLLPQSYTMSQAYSDLIKAFWPGALTLLFPVDTQRPAVPTVVTCGHPSVAVRMPSHPIARALIAISGLPMAGPSANASGRPSPTTAGHVLRDLGGQLDAESSSADASQAPKGRLRYILDGGACQVGVESTVIDGITAADEVRVLRPGGVTVEQIASVLDKAGLANKVKLRVYGKDMERSVEQESNPTTPGMKYRHYSPTARVVLLLPANLFARAAQSSGSNNTSGSRSQPDSSSSTKVVETLLNVESNLSIAPRSFADIVRDQITNHLSSAQPRSTLHIGLMISCDSALSRLVTTASHATDAPTSDMHPHLLRPLALEQLENVRVHPFDLGPSGSAEVYAQRMFDGLRTLDEGPLHGADRCDLIFVEAMDDAGVGLAVMNRLKKAASATVVLDC
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MPPRASKRKSAPPNSSSVTSSDGRSVSSKAKIKGLEKIDRLFNTYANSSLGMIDPEGIEALCSDLGVDYTDVRILMLAWKLKAEKQGYFTQDEWQTGLKALGVDSLSKLKKALSDLEKEVEKPSNYEDFYTYAFRYCLTEEKQKSVDIESICELLNLVLGVQFRPQIDSLIEYLKVQNDYKVINSDQWINFLRFCKEVNLLEMYKFANFIFPFAAITQYHKVSFHLHWKSVLAARMKKN
The following text describes a protein:
Function:
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPLKRPSPGPHPLDLNPYERLQFEEKENRRSHNDTDHHATLTSRQEGLRRRAALGENVDISADGESKEDEGYSAEKRNDRLSSPEDTKTGEGKGKKSPLMSNLKLDDFRDTLEAGIERKFAPLHIPPHRRLQTAAVALWALLLPICMIVLLLLLSLPPMWLILIPYFIWISFDRAPIHGGRPKEWARKGFIWKYFADYYPCSIVKEAELPPNRPYLFGYHPHGIIGMGAFATFATEGTNFSEYFPGIKPHLLTLGSNFKIPFYRELLMIHGCGSVSKRSCANVLSQGPGSAIAIVIGGASESLSAHPGTADLTLKKRFGFVKMAIREGADLVPVFSFGENDIYAQLANAKGSMVYKLQKKFEKVFGFTLPLFYGRGLFNYNYGLMPFRHPIVSVVGKPIHVERDPHPSDEKVQELQSKYIAELTRIWDKYKDLYARGRTKELTLVE
The following text describes a protein:
Function:
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.
Sequence:
MAPSMKNSHSSSNCGGEVVGSQANVLASCYIVDSSARLSGFHYSTTGAGGGIPEVRSGSTSPPSSPPLAALRSANEFAFINNLSKKQDARGRTTSRKEGAAYAIREECERLFCENMKTIFLGEEGSASNDSNLMGADTYSSLDDDVDTHNNYFGNVKSGHSIDAWFEIWDYTGGCSFRGFVGGNGDEKTLFAFFDDSVIGRDLKHGLMALIELADEVFAVSQVVVCVDRSIPDGDRSAFLKSLRWVGFELTTLDMWSSQLDTTSDKWLLMGLEV
The following text describes a protein:
Function:
Probable transporter of a GTP-driven Fe(2+) uptake system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTKQFHCVTVGNPNAGKSTLFNALTGANQQVGNWSGVTVEKKTGHFTLNGADVYLTDLPGIYDLLPAGNSCDCSLDEQIAQQYLAEQRVDGIINLVDATNIERHLYLTAQLRELSIPMVVVLNKIDAAIKRGICVDLTKMSQELGCPVIGVCSRDPADVAKVQAQVLDLLQGRVSEAPLLLDYDKQIEAGVQLLCRKDPNLSRGRALAMLGNGSGCGSCKNAQLQDEVNTCTQQIAQQGHDIEVMVATTRFNFVERVFQSSVKADGFLTLSDKLDKLVLHPVLGIPVFLFVMYLMFMFSINIGSAFIDFFDVFAGALLVDHFGALLTNIGAPAWVVTILAGGVGQGIQTVSTFIPVIAALFLGLSILESSGYMARAAFVVDGLMRRIGLPGKAFVPMIVGFGCSVPAIMATRTLGSERERIVTGMMAPFMSCGARLPVYALFAAAFFPDSGQNLVFLLYVIGIFAAIGTGLLLRSTLLPGTSSAVVMELPSYELPKFKAVMVRTGKRTKSFILGAGKTIVLVVTLLNFINAIGVDGSFGHEDSQASLLSVASQKVTPIFAPMGIEQDNWPATVGIITGIFAKEAVVGTLNSLYTNATPEGSELTPLADSFNEALATIPANLFGLDLEDPLKLSVGDVSNTEVAAETQGVATSTFSALQSGFTTKVAAFSYLLFILLYTPCVAAMGALVNEFGTRWATFAATWTFALAYGSATVVYQAATFAAHPLQSSLWIGFFLVALVMFYLWLKRKGRRTQQIIPGVRIITE
The following text describes a protein:
Function:
Required for the apical cell cortex localization, total cellular level and full activity of dachs.
Subcellular Localization:
Cytoplasm. Cytoplasm, cell cortex. Note=Low levels are found diffusely in the cytoplasm with high levels concentrated at the subapical cell cortex.
Sequence:
MAFLCPVRMRRDKKKATNASIERDLPAVGVLGMGRITGSSSIETLVRVGIEKEHGLSPDSKMVVLHDFTPCVDDELEVKRGQLVNILYRENDWVYVIGQDSRQEGFIPFSYCAPCNTQLADLAVKKKLPREQCPEQPIEENIPLLGTDNKLDVLCDETLNPGSANSIENTLLVEPECTPFVKEPSGRCIVLYTFIARDENDLSVERGEFVTVLNREDPDWFWIMRSDGQEGFVPASFIYPADSVRVLQQQKATLNAMETILQQGQQGQQSQQQQQPQLGLGTDDLRYHGTELVMLYDYKAQAPDDLYLSVRRGDWIYADLTNQTVDGWLWAYAPKTRKYGFIPKAYARPPAMTSL
The following text describes a protein:
Function:
Transcription factor. May be involved in the differentiation of stomatal guard cells.
Subcellular Localization:
Nucleus.
Sequence:
MTLEALSSNGLLNFLLSETLSPTPFKSLVDLEPLPENDVIISKNTISEISNQEPPPQRQPPATNRGKKRRRRKPRVCKNEEEAENQRMTHIAVERNRRRQMNQHLSVLRSLMPQPFAHKGDQASIVGGAIDFIKELEHKLLSLEAQKHHNAKLNQSVTSSTSQDSNGEQENPHQPSSLSLSQFFLHSYDPSQENRNGSTSSVKTPMEDLEVTLIETHANIRILSRRRGFRWSTLATTKPPQLSKLVASLQSLSLSILHLSVTTLDNYAIYSISAKVEESCQLSSVDDIAGAVHHMLSIIEEEPFCCSSMSELPFDFSLNHSNVTHSL
The following text describes a protein:
Function:
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Sequence:
MTHVEVVATIAPQLSIEETLIQKINHRIDAIDVLELRIDQIENVTVDQVAEMITKLKVMQDSFKLLVTYRTKLQGGYGQFTNDSYLNLISDLANINGIDMIDIEWQADIDIEKHQRIITHLQQYNKEVVISHHNFESTPPLDELQFIFFKMQKFNPEYVKLAVMPHNKNDVLNLLQAMSTFSDTMDCKVVGISMSKLGLISRTAQGVFGGALTYGCIGVPQAPGQIDVTDLKAQVTLY
The following text describes a protein:
Function:
Probable membrane-bound O-acyltransferase (By similarity). Together with GUP1, has an influence on the chemical composition of the yeast extracellular matrix (yECM) in yeast multicellular aggregates, such as biofilms and colonies.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSMLRIWSCIVHFFSVQALDSRIKPDIEFKRRQRIFINSSKEENGSSSSAVTVTRNPVLSSNSPSPPLWNTWEFRLYYLAFTVVVPFMIKAALATSSESNPNYYKFSGLLAHGWILGRKVDNSDPQYRFFRSNFFLLAILILLQIILKKVFVKFSKIPKTKFDFACGLVFVCFMYGINSVKLFTHAFIFFTLAHSLKRKRLIAAFAIWSYGIFTLFINQKMKNLPFNNIAIILSPMDQWYKGIVPRWDFFFNFTLLRLLSYSMDFLERWHEQLSRQPSIDYDDRRPEFRKSLSGSTLQTIYESGKNVLEEKERLVAEHHIQDYNFINFIAYITYAPLFLVGPIITFNDYLYQSENKLPSLTKKNIGFYALKVFSSLLLMEIILHYIYVGAIARTKAWNNDTPLQQAMIALFNLNIMYLKLLIPWRLFRLWAMVDGIDAPENMLRCVDNNYSTVGFWRAWHTSFNKWVIRYIYVPFGGSNNKILTSFAVFSFVAIWHDIQLRVLFWGWLTVLLLLGETYITNCFSRYRFRSWYRFVCGIGAAINICMMMIINVYGFCLGAEGTKLLLKGIFNNSHSPEFLTAVMVSLFIAVQVMFEIREEEKRHGINLKC
The following text describes a protein:
Function:
Acts as a protein folding chaperone for elongation factor 1-alpha.
Subcellular Localization:
Nucleus.
Sequence:
MSTEGESAAPQGNVVVESQFQKPGDLVERNDDTGVMSVESLCMNCHENGVTRLLLLRVPFFRDIILESFECEHCGHRDNSVKSAGQIQEKGTKYTLDVENEEDFQRQVIRSDVSIFRVESLGIEMPKGESQLTTVEGVIQRIYENLSSDQPLRKEQAPELHDALVPIIEKLEKILKREGFPFTISLDDPTGNSWIAPNTQDKTNKYRRRDYPRTHEQNEELGIAADPEAQKNEGINVEGEIDDSEIVEGQVYSLPAECPGCTKACFVNMKKVNIPYFKEVFIWGTVCDHCGYRTSEVKTGGEVPEKGKRITLRVENEVDLSRDILKSDTCALHSEELEVTVQPGTLGGRFTTVEGLLTEIRDQLHGQIFDVDDTTNSGGDSMAASDKEKWERFFSRLNDAISGKMKFVITLEDPMANSYVQDLCAPAPDPQITTEEYTRTEEEEEELGLKDMKVEGYEQEQKEEKPAEEADERKS
The following text describes a protein:
Function:
Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Sequence:
MDISQYEMDNSKSCVLTSGTPQAAQNEPCCLGIDEAGRGPVLGAMVYGACYYPLSQSEKVKELGVADSKVLTEDMRDELFQKINSDDSVGWLVEIISPSDISTKMLARTKYSLNAVSHDAAINLIRQSIQKGVQVKEIYVDTVGVAENYQNKLSELFPDITIKVTPKADALFPCVSAASIIAKVTRDKVLSNWKFPEDESYNSSDYGCGYPSDPATQKWLNSNLDKVFGYPQFVRFSWSTCQKILDESAVRVHWEDDEEFDNDNTVSLLSFFTQKGVQEKAVKRHNFLESRKLKQVVKF
The following text describes a protein:
Function:
Receptor for gastrin-releasing peptide (GRP). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (By similarity). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDPNNCSHLNLEVDPFLSCNNTFNQTLNPPKMDNWFHPGIIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYIIPLSIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFITSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPSLLNRSHSTGRSTTCMTSFKSTNPSATFSLINGNICHEGYV
The following text describes a protein:
Function:
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein; [Isoform 2]: Secreted.
Sequence:
MAQHGAMGAFRALCGLALLCALSLGQRPTGGPGCGPGRLLLGTGTDARCCRVHTTRCCRDYPGEECCSEWDCMCVQPEFHCGDPCCTTCRHHPCPPGQGVQSQGKFSFGFQCIDCASGTFSGGHEGHCKPWTDCTQFGFLTVFPGNKTHNAVCVPGSPPAEPLGWLTVVLLAVAACVLLLTSAQLGLHIWQLRSQCMWPRETQLLLEVPPSTEDARSCQFPEEERGERSAEEKGRLGDLWV
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGRSPISDDSGLKKGPWTPDEDEKLVNYVQKHGHSSWRALPKLAGLNRCGKSCRLRWTNYLRPDIKRGRFSPDEEQTILNLHSVLGNKWSTIANQLPGRTDNEIKNFWNTHLKKKLIQMGFDPMTHRPRTDIFSGLSQLMSLSSNLRGFVDLQQQFPIDQEHTILKLQTEMAKLQLFQYLLQPSSMSNNVNPNDFDTLSLLNSIASFKETSNNTTSNNLDLGFLGSYLQDFHSLPSLKTLNSNMEPSSVFPQNLDDNHFKFSTQRENLPVSPIWLSDPSSTTPAHVNDDLIFNQYGIEDVNSNITSSSGQESGASASAAWPDHLLDDSIFSDIP
The following text describes a protein:
Function:
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
Sequence:
MVQMKYRVIEIFTSIQGEGEVIGIPSNFIRLATCNLRCVWCDTKYSWEIGTEMSIDEIIAKLDKKIKTTTITGGEPLLQNILPLAKELKSIGHKIVVETNGTIKPSEELRKIIDIFSVSPKLSNSGHKLKYDFADDWATYYKFVIVYPNKDIDEVVKFVESQSINPRKVILQPDGNRSDYINAINEIVQIVLDRGLQFRVLPQLHRIIGAR
The following text describes a protein:
Function:
[Capsid scaffolding protein]: Acts as a scaffold protein by binding major capsid protein in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein. Cleavages products are evicted from the capsid before or during DNA packaging; [Assemblin]: Protease that plays an essential role in virion assembly within the nucleus. Catalyzes the cleavage of the assembly protein after formation of the spherical procapsid. By that cleavage, the capsid matures and gains its icosahedral shape. The cleavage sites seem to include -Ala-Ser-, -Ala-Ala-, as well as Ala-Thr bonds. Assemblin and cleavages products are evicted from the capsid before or during DNA packaging; [Assembly protein]: Plays a major role in capsid assembly. Acts as a scaffold protein by binding major capsid protein. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Cleaved by assemblin after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging.
Subcellular Localization:
[Capsid scaffolding protein]: Host cytoplasm; [Assemblin]: Host nucleus; [Assembly protein]: Host nucleus.
Domain:
Region of interaction between pPR and pAP is called Amino conserved domain (ACD). The region of interaction with major capsid protein is called carboxyl conserved domain (CCD).
Sequence:
MAAEADEENCEALYVAGYLALYSKDEGELNITPEIVRSALPPTSKIPINIDHRKDCVVGEVIAIIEDIRGPFFLGIVRCPQLHAVLFEAAHSNFFGNRDSVLSPLERALYLVTNYLPSVSLSSKRLSPNEIPDGNFFTHVALCVVGRRVGTVVNYDCTPESSIEPFRVLSMESKARLLSLVKDYAGLNKVWKVSEDKLAKVLLSTAVNNMLLRDRWDVVAKRRREAGIMGHVYLQASTGYGLARITNVNGVESKLPNAGVINATFHPGGPIYDLALGVGESNEDCEKTVPHLKVTQLCRNDSDMASVAGNASNISPQPPSGVPTGGEFVLIPTAYYSQLLTGQTKNPQVSIGAPNNGQYIVGPYGSPHPPAFPPNTGGYGCPPGHFGGPYGFPGYPPPNRLEMQMSAFMNALAAERGIDLQTPCVNFPDKTDVRRPGKRDFKSMDQRELDSFYSGESQMDGEFPSNIYFPGEPTYITHRRRRVSPSYWQRRHRVSNGQHEELAGVVAKLQQEVTELKSQNGTQMPLSHHTNIPEGTRDPRISILLKQLQSVSGLCSSQNTTSTPHTDTVGQDVNAVEASSKAPLIQGSTADDADMFANQMMVGRC
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MADRVPAIFHYGPADEDIQAAAQPEESAGRDEAAAAGAVAAKQTVSEQEQRVQPAQGTRRLQERGSVTARPLPVRNADIGGPQVKASANDEGQSGRGSGSSMAGVQQADQAVSGNLRSQPKSKKAAKPPRGGPKKVGKDLGPPPKAAVEPIVEEVDTNDRLRREKAEILARTLREHNAAVFEAQMALLEGPTTDKQLQASRRLLPKSDYDDIIEERAIAGVCGYPLCDNVLPQKDSRKGHYRISLAHKRVFDTSDTVRFCGLDHVVRSGAFRASLEDERPLLPTGDELQAIVATVTGRPGGAEKRASFQAADVTKRRPEEEGSSASPAVMSATLVERTPGDVSADVSAPEAGQSDAIEGYVPRRGAQKRSVDGSVGARSRKSGPVKGAASREAERKVEQESGLQKNGETDATKVVSGRREADLTMAGMGTGFGESGAEWSRRLDQSAAEAGISVSRYTEGEKESPVPTEAGSTDEASRQRIDAASSGMTSEPRPSKRSAEEKGKAHGAAGKGVVESLKKGANGATDFASDRGQPEEEPDLRLQSAQAVATALAEAAARVETGEFDATEAMQSLGMTVQPANEGAPSGSRRDARSKRASASLTEISGLENEEGPEESGGVKRGLETGGVVERNESENRQTEQGRGSNATSTSGASVTPEEDEDDDSGQGWMGAPPQGFSAELSQFGRLWTALDSWISADTLRFLHGPDAFFQGGESEGGVISVGGRDYEPRVVLDNGASAAIRRAFQECVRRALPDVQRAMQLKVPRPELEEALGNLVRTFSFTDPLPPLKSPGWQLLTLLMLHALSRRSTPVLGSSFEDRPSLGQALETLKGDKKEYELLHAKLVPAGSTNG
The following text describes a protein:
Function:
Fatty-acid-binding protein. Associates with saturated fatty acid.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Derived from proteomicsdata.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MSNMDPNSVLPKRSFLQHELFSQLHIPGSLAFEAFSCISKFTGALLCWFSHGNLQKEVSKHQWGLTCKSRDSLKHVFEHRNVSVFPFHYVSKDISPGFFGNISKSTIQHFVNEAERLHSCSLLSLAAAMIPSLNVMSANGLALPLGSNDVKLRENIEHRTCPENTEHRTCQVGCEEYSGLSFQKLDWTRQSVEPRTGIEFPMLLKENASRSNSEVLVATGSRTMKIIRIKSLKVYAFGFYVHPSSVCQKLGRKYASVPASKLDKCDDLYKDLLREDIVMSVRLVVNYNGLKINTVRDVFEKSLRARLVKANPKTDFNCLNDFGSFFRQDIPIPAGTIIDFRRTEDGQLITEIGGNLIGAVRSKDLCRAFFGMYIGDVPVSEQTKEEIGRKVVGIIKRC
The following text describes a protein:
Function:
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer.
Sequence:
MFEEMMQEESGSPVSPVDSLSNSEEELDRQQKRCGRKRRSSRKNGEDSDSPTPGKRGKKSSSSSPQSFEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDELDSKMASCSYVAHERLSYAFSVWRMEGAWSMSASH
The following text describes a protein:
Function:
Involved in the degradation of 3,6-anhydro-L-galactose, which is the major monomeric sugar of red macroalgae. Catalyzes the oxidation of 3,6-anhydro-L-galactose (AHG) to form 3,6-anhydrogalactonate (AHGA). Shows broad substrate specificity, with maximum activity toward AHG. The enzyme activities toward D-fructose, D-galactose and D-ribose are between 40% and 50% of the maximum, but those toward L-rhamnose, L-glyceraldehyde, D-glyceraldehyde, L-fucose and D-glucose are much lower.
Sequence:
MTHELFDSKGLLGSAPAAFVAGEYELDSSHGTLPVINPANGQLVAEVPSSSSSTVDRAVTAAVAAQREWGRRSHVARAAVLEAVRDAIAVHADELARIVSVEQGKPLSDARGETEGACAFFDFAISQKYRAVGSMMASEPGRSLGVREEPIGVVAAILPWNFPVAIFARKVAPALMAGNAVVLKPSELTPLSALALARLCRLAGVPDGLLSVVCGEGKDTGRALVTHPGVGMVTMTGSTRGGREILAQVADQIIPVSLELGGKAPFIVFEDADLDAAVEAAADARLWNTGQVCTCNEVTYVHADLHDEFVRRVVDRFASVTPLDPFAAGSRLGPLVAERERTRVQGMVDAAVAAGARVRTGGGRPDGEQYQSGAWFAPTVLTNVRPEMDIARREVFGPVLPIIPFDAEAEVVSAANSTAYGLTAYVYTRDLSRAMRMIDALEFGEVYVNQAGPEQVQGFHTGWKSSGLGGDDGPHGYEKYLRRKTVYVRHAV
The following text describes a protein:
Function:
Translation factor for cob1/cytochrome b; plays a role in cob1 mRNA stabilization and required for correct folding of the protein.
Subcellular Localization:
Mitochondrion.
Sequence:
MLKTLSKVSKNLSNTSAFLVKSKPLYISFCTCKAYFEDNTSLSRRFFSAKKSLQFKSLIRKYSEDSTLAWRDYENYNDDDLLYQRELSEIYNKCLKALHPFYPVFEVNSNLYYQLLMFTNYSNPKDNGFSKLLFSQYSDEKKVLVNFVYNVLRLDPDLQRQKRILESIISAALNICVSTVNLSRTDLKSSLKIILQTIDLFKYDSSFSSIYFRKDGPYHKVEKLLKSANIRSSLNSKTFNDFRTLFLLLIRDYSLFHGNSSHCMLANSMLPPSIAFSKMEKAEIFLRLRAFFQLMEHIDNERITPSEQFLDKVFISLLSAKNSCSLKMWLIHSFNKGWPVKIEFFVSFFKNFSNIVEGSMEVYSAYLHIIRDHYNLSDLADVQAIFLSRFILLRKKEDCKKLLEHVLPIRQLFLLNCYSLLNVLANYVVVFKDRLIFQEINQNWEEHKGQIPENFIFSLLKMFGEMQENQGFLNACIYYINKKKNLNEVSRYKINLLLLQGVNSFEVKDFYRKRGIEIMPKNLPRFFCYCLKKNKLSYALKYIRLSGLQFDYIVDCFRNSSDWTRTLISILSKKMGTEFAIRFLKIISFPLLSNDKVLREIEFFAIHEVNFRSLKWVADQQLRILPGWSSRPQKATFPLCTVHLKK
The following text describes a protein:
Function:
Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhibition of TNF-induced NF-kappa-B activation by regulating the dephosphorylation of TRAF2.
Sequence:
MADLSLLQEDLQEEIEGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENVFNRQMVARSLLDTLKEVSDDERDCIAVLERVSRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKYLLPIVVRYLADQNNQVRKTSQAALLALLEQELIDRYDVETNVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATSQEIRRTKLSTLFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEENKNSEDIVLEEKTSERIGDGDDFSENVQFRTEAIPLDVCLCKSSLRLENNLDDHTQTCRKSLSESHIHMDRSLHSTLSSVSLHSILQEAVDEIEQSSDSCAITLLPEMDISSPEQPYLDQELYNSFHFWRTPLPEIDLDLELEQDTEKTLESPEGTPKVTLPDSPNITMATRKELEEMIENLEPHIDDPDVKAILGEKEGSRKGLLPGMDGTLIIDTKEAQVEVLSAALRATSMDTQEEKMVSLARENDLQDEILIKELQNCKISQDDPVPLINDTVESMDSTLQYIHNDSDLSTDNSFSPEEERKSKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAIILGDQLTAADLVPIFNGFLKDLDEVRIGVLKHLHDFLKLLHMDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLDLYNPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHMATPPTFGVDLINELVENFGRCPKWSGRQTFVFVCQTIIEDDCLPMDQFAVHLMPHLLNLANDSVPNVRVLLAKTLRQTLLEKEYFLSSANSHQEAVEQTIMALQMDSDSDVKYFASIHPSNTKIAEDAMSTASSTY
The following text describes a protein:
Function:
Acts as a magnesium transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MDSKTSHLDDELCFKLEEAFDTLTAGEHSQDLTSIVSVYNPIDLAYAVSCLPSDSRSILYKNLDSIASKIAFIINTDSASRWAIFRNLSDGEICALIEQMPPDEAIWVLDDIPDRRYRRILDLIDVKKALKIRDLQKHGRNTAGRLMTNEFFAFLMETTVKEVATCIRNNPGIDLTRLVFVLDFKGELQGFVTDRSLIIASPEMPLKQIMRPIEHKVLADTTREEVVDLVERYKVAVLPVVDEENFLIGAITYEDVVETIEDIADETIARMAGTTEDVGYHDCHVVQRFLLRAPWLLITLCAGLVSASVMAYFQKIAPTLLAMVIFFIPLVNGLSGNVGVQCSTILVRSMATGTLSFGRRRETILKEMSIGLLTGVALGILCGLVVCCMGCLGLGLFATGGVQLGVTVSVGILGASLTATTLGVLSPFFFAKIGVDPALASGPIVTALNDIMSMVIFLLITGTLNVLFFK
The following text describes a protein:
Function:
Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is still unclear: may act as a protein kinase that mediates phosphorylation of COQ3. According to other reports, acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. However, the small molecule kinase activity was not confirmed by another publication. Shows an unusual selectivity for binding ADP over ATP.
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MASDMVLLMRGLAKLSQAVVETQTNALRNGTAVQGVGTAVESVQAAAEQGLSAAMMKIQELSGQQQTSSESEFDFPQEEAEFTASEFREEGMDAEADCSRSSADEAPGVGGTQSVFQGYKDPSKQFGGHSRSYHQDARHFFGHPLYNHELNRRIWQKVYFQPGQFRNYHQDPPSMEGLTAEDIAKTGQSKRGDSKPHKQMLSERARERKVPVTRLSRLANFGGLAVGLGIGALAEVAKKSIGFNGASGENKKSVLDSSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPIKQMTKALNSDLGPNWRDKLEFFEERPFAAASIGQVHLARMKDGREVAMKIQYPGVAQSINSDVNNLMTVLNMSNALPEGLFPEHLIDVMRKELALECDYIREAQCAKKFRELLKDDPFFFVPEVIDELSSKLVLTTELVPGFPLDKAESLSQELKNEICQNILLLCLRELFEFRYMQTDPNWSNFLYDPQTHRVALLDFGATRGFDQSFTDIYIEIIRCAAQGNREGVLKKSIEMKFLTGYESKAMTNAHVDAVMILGEAFASYEVFDFGSQSTTERIHNLIPVMLRHRLTPPPEETYSLHRKMGGSFLICSRLNAKLSCKDMFETAYRNYWEGRRPTPF
The following text describes a protein:
Function:
Putative tyrosine-protein phosphatase required for protection against superoxide stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MASITSNSQILINNDSSTNKAPTTNERQLRRINHPPNLRIVPPLNFCPVENQLYRSGQPSIINQSFLNQLNLKTIIWLSSEEPTDEFLEYCNDSSINIEYLGMINEFNSEPATATTTDKQSQSQSQSQSEEQKSQSQSQSQENQHHQFEQSDNNLLQDPSHLISSTIAKINNNNPWDSLNENTIKHALDLIVDKTNYPILICCGMGRHRTGTVIGCLRRLQHWNLNSVSEEYRRFTGSRGGRILVELLIESFNIDLVNINWELAPDWLK
The following text describes a protein:
Function:
Activates the Pk92B/DASK1-MAPK signaling cascade.
Sequence:
MNILNPGKFKCIVFDQLRHTWTFLLFICDFLAKIYRTPRITAHQEQLANHNNNNNNNNDLIMEQDMPEEEVGQPEEALPQQDNGEVVDRFNAIQAAVELMDAASDLDEEEEEEDDDVDVDVDYGDTDSESEFEEMYSDEWTSSSDELDEGTELSKSVLNVFLSSDKQQSQMAGQIPMYAFQPLRLVKCQYRDKHIPGGFPLARSGHRIIASNSHLYSLGGYNPRSAMSASRHGRCLLFQELWSYNFATRTWRLELNAGNAANMPVELASNALTIHNNVLISHGGTGYPFGVSCSNDCYVYRTASAGATPGVDRLQVKGDLPTAQYGPGIVIHKHFLYTIGGTTGFDYTCDVYRLDLRTGIWENVYISRPEMRDDPEGRYRHEVVYDGKHIFVLGGGTSHSVYDLQRIPAYNLEANCWDYFETYPDQRAADADDGNRGYPKPRKCFSCVQHQSSTGDIEAFITGGLQGDFSTYFSDIWKLNLRTKHWYRIETAILPRPLYFHSAAHSDNGCMYVFGGIEYIDKEMRRRNDLYKMWMTVPKLSEMCWDAITYYNDNLDLYDRKTLLEAGIPKRFTERLPPQRRRRLDTSQPDPSMLISLYSNPKRARSSTQ
The following text describes a protein:
Function:
Probable transcriptional activator that binds to the DNA sequence 5'-[AG]CCGAC-3' of the cis-acting dehydration-responsive element (DRE).
Subcellular Localization:
Nucleus.
Sequence:
MEMDIGEGESCCGRRKQQQQQNISSSKSRKCCPLRRSRKGCMKGKGGPENQRCPFRGVRQRTWGKWVAEIREPNRGARLWLGTFNTALDAARAYDSAARALYGDCARLNLLLAAATAGAPPAAATPSVATPCSTNDDSNNSSSTTHQQQLTTMLQLDDDNYTLQPSSSDQEDFETYVTRLPKAEDFGLEGFQEVPLDVLDEAGGGISIWDLSICPADFMATAATTTAKSS
The following text describes a protein:
Function:
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
Subcellular Localization:
Cytoplasm.
Sequence:
MSKTLKGIAASDGIAVAPAYLLVEPDLSFSKTSVSDVDAEVARFKKVVEESTKELEKVRDKAKESLGPEEAQVFDAHLLFLSDPEFTGAIETEIKDQKINAEAALDETAQKFITIFEGMTDNAYMQERAADVRDVSKRLMAHLLGKKLPDPAAIDHEVVVVAYDLTPSDTAQLNKKYVKGFVTDVGGRTAHSAIMARSLEIPAVVGTETITKDVKDGDMLIADGLDGDAIINPTDAQIEEYTKKGEAFAKQKEEWKKLKNEPSVTANGKKFIIAANIGTPNDMKGVKENGAEAIGLYRTEFLYMDSKDFPSEEAQFDAYKKVIEDMDGKQTIIRTCDIGGDKHLDYWDLPEEMNPFLGVRAIRLSMQYKDIFRTQLRALLRASAYGPLGIMFPMIGTLAELREAKQILAEEKDKLAKEGVKIGDDLQVGMMIEVPAAAVLADQFAKEVDFFSIGTNDLIQYTMAADRGNDNVSYLYQPYNPSVLRLIKHTIDGAHENGIWCGMCGEAAGDDIMFPILLSMGLDEYSMSATSILRIRSLMKKINTEDIKELANKACFVSETADENKKLVEETMKKLNILD