lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminopimelate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
Sequence:
MDALEITQKLISYPTITPKECGIFEYIKSLFPHFKTLECGENGVKNLFLYRIFNPPKDHAEEKHAKENTKPLHFCFAGHIDVVPPGNHWQSDPFKPVIKEGFLYGRGAQDMKGGVGAFLSASLNFNPKTPFLLSILLTSDEEGPGIFGTRLMLEKLKEKDLLPHMAIVAEPTCEKVLGDSIKIGRRGSINGKLILKGVQGHVAYPQKCQNPIDTLASVLPLISGVNLDNGDEYFDPSKLVITNLHAGLGANNITPASVEIIFNARHSLKTTKESLKEYLEKVLKDLPYTLELESSSSPFITASHSKLTSVLKENILKTCHTTPLLNTKGGTSDARFFSAHGIEVVEFGVINDRIHAIDERVSLKELELLEKVFLGVLEGLSEA
The following text describes a protein:
Function:
Dioxygenase that repairs alkylated DNA containing 1-methyladenine and 1-ethenoadenine by oxidative demethylation. Accepts double-stranded and single-stranded substrates, with a preference for dsDNA over ssDNA. Confers resistance to methylating agents such as methylmethanesulphonate (MMS).
Subcellular Localization:
Nucleus.
Sequence:
MTNPLNSTAANRSNQPSSDGISDGQITNEEAESLINKKNCSGHKLKEVTDSDTFSDNGKDDSDTKKRFHYHQDQRRMSLTSIVAVESPSSSNAPSRKTIDLGHGSDLIYIQRFLPFQQSWTFFDYLDKHIPWTRPTIRVFGRSCLQPRDTCYVASSGLTALVYSGYRPTSYSWDDFPPLKEILDAIYKVLPGSRFNSLLLNRYKGASDYVAWHADDEKIYGPTPEIASVSFGCERDFVLKKKKDEESSQGKTGDSGPAKKRLKRSSREDQQSLTLKHGSLLVMRGYTQRDWIHSVPKRAKAEGTRINLTFRLVL
The following text describes a protein:
Function:
Participates in DNA repair and in chromosomal DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MNDRKIVEAFKMYQKKPQRSAVVALKEYLNAVSDQEAMLEHIINEIMKLIGDETNVDKEIIEKVLTNIQKQNSISHQVFDFQSAFDAPKFEFDMNTQNLVPSTQPKSILGKGPSKISLYRERFQILKYSLINSKAFAKSALKFWSDDDGSLSIVDIATLVSKPHDSTVVFIGILDYEGEVYTVEDESGVINLAISPECQFFGGILPVGCIVVVQGKALGDYVNALVIGHPPALTTSDFMNKFWSLPYDPFGWNLNRESMSNLQSILHEEHENALILVFSDVWIDVPSCVTEFSHVLQNYDSSPPNMIILCGSFTQKPLPFNGMKQFERDFRKFIKKISDEHTAMIQNSKFVFIPSLTDPGAPKVFPRLLFQDSIKNMFPEAIFMSNPCKIRFLSRTITVFRDDIMSRLARASPRTVPEENEHENLLITIIHQAHLTPTDLAHAPVAWEYDHTMRLFPAPDCLILADAAAPWRSEEGDTVAFNPGQFGNGGTFGLYSPAENTCLLQKLA
The following text describes a protein:
Function:
Mediates sugar transport across membranes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MFEDLSLVSVMSLLATVCTVGQFLTGSVIASKITQQGSTAGVTVYPFLTTLINCTFWLKYGVLVQDKTLVVVNSIGALLQTSYLVVYYVYTKQKNTLHNQLLAGGAVLFPVLIYVKFFSPDDSVAAFHLGLMASGCAVLMYGSPLATMAEVLKTRCTETMTPALSVANFVVSSEWYIYGRLVNDLFIQVPNLLGALLGLIQLALLVCYPRTPKAANANHA
The following text describes a protein:
Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can regulate their activity. Thought to have a role in the uptake of lipids and proteins in the intestinal cells; operates in the apical uptake of lipid markers and trafficking of yolk proteins. Affects fecundity and egg laying.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Apical cell membrane. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).
Sequence:
MTRQNTSESDNTQRPPIPQYDTVDDIDELTDAMDKEDHHHHHHHHEHHHQHQGIAQYDTVEEVETLETVHHRTSLNQEVPTPQRRSHPQYDNLDDIDDQEYITEVEVKSNRGSTLTTRPHVTIKQDEIEDIGERQVTVIEIASQKGSTKRVAPRKDYAPSIPLPEHPAQQSAPPTQQSRPQTTSHKPPNPEMEFDIGVKNIAPVLIHKMNMDDRDPKDSAQYLNTSFFEVFNEPSEQYHSIACVWTLSFKIFEIVRIYSYKILTLIFGLIIAFLGGILFALFAFLNIWIFRPILILTRMAFAQIVLIWPMFLIYIVRPFFYSVGAIFSTARLHTSRGEQVVEVWEKHIHHV
The following text describes a protein:
Function:
Regulatory component of a deubiquitinase complex consisting of bam and otu. The complex deubiquitinates K63-linked polyubiquitinated proteins, antagonizing the ubiquitination activity of Traf6 and regulating the IMD immune signaling pathway. Otu-bam deubiquitinase activity is regulated by Traf6 dependent immune signaling regulation of bam expression levels; this forms a feedback loop that regulates the IMD immune signaling pathway and balances gut immune activity during aging. The complex deubiquitinates and stabilizes CycA/cyclin-A to regulate CycA-dependent differentiation. Required to initiate both male and female gametogenesis. Part of a complex with bgcn involved in 3'-UTR-dependent translational repression of a subset of mRNAs, including those for mei-P26, nanos and shg/E-cadherin. Repression of mei-P26 is targeted by let-7 miRNA. Involved in a regulatory cascade with mei-P26 to control the progression of cystocytes through transit amplification and the switch to spermatocyte differentiation; mei-P26 facilitates bam accumulation, which in turn represses translation of mei-P26. Forms a complex with tut and bgcn involved in 3'-UTR-dependent post-transcriptional repression of several 3'-RNA processing factors, which promotes germline stem cell lineage differentiation and mitosis-to-meiosis transition.
Subcellular Localization:
Cytoplasm.
Domain:
May possess a C-terminal PEST sequence (rich in Pro, Glu, Ser and Thr) targeting it for degradation and rapid protein turnover.
Sequence:
MLNARDVCPEGNDDQQLDHNFKQMEEHLALMVEGNENEDPRKATCEYEDTNEDGATCTSGVLSEIQENFGRLRLCDVTAPLLEFHGLDCLQQIQKRSRHFAFDGSPAKKSRSGGVLVTGPKQKQLQKENVWNRKSKGSASADNIEKLPITIEKLHMIGLHGDCLEHNAVLRLMNLFRSLHDHLTADLGFSRQNSMPSDYLFDMPVKSTMPKSLNVRYQLQVLCTKVERFLVQQRRTLEANRHFDFEKYDECDKLLKGFASYLDNFKLLLKPKMRNRNGNSGSNADKFHTQRMERLLIGLRDWIKAAHLSVHVFNWEMDLEHRYSGAMTESHKSLNERAILLSGAELRAAEARGISAEDLFIAQRYKLGGPIYCVLEQHEFLSALIANPETYFPPSVVAICGPQKLGAVSMEQPSASEEEFEETEEVPSSPPRHTGRVPRFRS
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
MALCYPMAMGLNKSHKVTKNVNKPRYSRRCCLLTKLSKFLRDMIWAVRSFAPFEGWSCSRSPSASGPSSSSKGWGHTSAPRGSEELSNVLAATRDAAAKKD
The following text describes a protein:
Function:
A major RuBisCO chaperone. Acts after GroEL-GroES chaperonin to fold and/or assemble the large subunit of RuBisCO (ccbL, rbcL). Cooperates with RbcX in RbcL folding, plays the major role in assembly of dimers into RbcL(8)-Raf1(8) intermediate complexes. RbcS replaces Raf1, leading to holoenzyme formation; Raf1 and RbcX are probably functionally redundant; it has been suggested they may cooperate.
Subcellular Localization:
Cytoplasm.
Domain:
Has 3 domains, the N-terminal alpha-helical domain, an extended flexible linker and the C-terminal beta-sheet domain. The 2 C-terminal beta-sheet domains are swapped and pack against each other to form the dimer interface.
Sequence:
MIGQPQSPEYKLSPEETDALFRSLLHKEGTWVEWGVGCQQLQQSGHSAQEIFEQTGFQTAQQNMIIVAAQVYQSIASSGVPEDLLAYCRGPRSDVLYELRILSHSQRAIAAQVCQAKSLEFDGAKELARAMQEFARLPQIPDSFTEHPGDAVAYQAWRSAKQKKDLQDRTRLIAKGLKFAHSATARQKIEQLLSDLTTSPTKAAPLLPLYRYDEDTNVPLLIPVAGSLPLESDRLLSVPPLKQASPFNLVTVATATSLVPLPSWQNVLTAGDPVVIFHQTDQLPQPIPGKPEPVLILLDRQQTTWNDNSYFAVDADGKVELGWFAEAPIAKILGQVLLVMRPKKILDENNLREPWQMDD
The following text describes a protein:
Function:
May be involved in arbuscular mycorrhizal (AM) symbiosis with AM fungi.
Sequence:
MTLSSALIKIFITFLFLQNHVNSQYSSPSKPQPSLGSTISFSITKFDDESPNIFVKGDTSISNGVLSLTKTDKYSGKPLQKSVGHATHLTPIHIWDETSGELADFSTSFSFIVNTNGSSLHGDGFTFFLGPLHFDLPKNSSGGYLGLFNPETALIASQNPIVAIEFDSFTNGWDPASPSQYTHIGIDVGSIDSVSTADWPLNVLPRNALGEARINYNSESKRLSAFVDYPGLGESTGVSFVVDLRSVLPEWVRVGFSAATGELVETHDIINWSFEAAL
The following text describes a protein:
Function:
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKIIVIGPRGKMGSLVTKSCYTNENIELVAAVAPKERDYIGQDLGIVANLGKNIDCKVVDNLENVIDKCDCIIDFTDPETSMDVFEKALKSKKSVVCGTTGFSEEEINRINEISKEIPLVLAGNTSMVVNLMYKLVELAANTIGNMSDIEIIEMHDRYKKDAPSGTSLEIGEVLAKTFNKELKELAQFGRCGKGEREEGKIAYHSLRAGDISSSHTVMFGLMGERLEITHHAHNWECFANGGCQAALFLRDKKPGIYSMKDVLGL
The following text describes a protein:
Function:
Involved in the pathway that organizes the prospore membrane (PSM) during sporulation.
Subcellular Localization:
Prospore membrane. Note=Towards the end of meiosis I, or early stages of meiosis II, it forms circular structures above the meiotic plaque. As soon as an assembled prospore membrane is visible during meiosis II, it is detected at the leading edge, which cover the ring-shape opening of the PSMs. Probably recruited to the leading edges by ADY3.
Sequence:
MGKKNRKGKENNAAKTSFLKVENIKNTNSGLELPSQDYTNVEEKESSPKTDFPLITKEHVNTKTDSNILDYPTIGDLVSSVEKLCVLKELKIAFPEVDDTLIKAILIASQGVLEPAFNSLLYYSSPEENTDFALPMKPISVEDYSKINVSEILQREIFDDIEDEFSGQGINGSMVISKIESELSSLAEHIGNISTPGSNREVAESTRNVAVAEGHNTILSNEDSILKGKEKGKEEEKEKGEEKGVNSLKGAAVKVVAKSLKNNRIPVTVKRNEPSNNLFDVLNCDESEEEEEQDVETNTSNQERKNQGGNTEVPEAQRDSADRLPAKDDGGYKSAFGTDSCGLFAADAKDEKKQVHPSRQELSFT
The following text describes a protein:
Function:
Autophagy factor required for autophagosome formation. Component of the atg1 kinase complex in which it stabilizes atg13. Is also responsible for recruiting downstream factors to the autophagosome-formation site. Has a role in meiosis and sporulation.
Subcellular Localization:
Cytoplasm. Nucleus. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MTNTVTIELKIGYKYAAEVVKAVLGVILFHRQFSTVPARTIDVLDITVPTLVGAELNEQLATKAAEFIDTIRNEAGANGQMILLLYERSPKKSWFGKGNTIPWEQWILHTTILEEGDSYQESSLSLEAAVEQIVQAVNLRSLSYLPPVAMDSGNYPYEIVTPTSTEGWGSLLKRMIIENVSGGD
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MDKKIIADVFQRHLEQLVSRLNEDVPAICILSGKEDGSIKPKTKALFVWLFGYDMIETVFLATKKQIFYLASDKKLQMMEETKQKLSGKFEVHFYKKGNDNRESFDKIRQKLGNVKLGMPTTEKQAGSLAAEWYEYKGWQQIVDANQLISDVLAVKDDQEQGFIQQSSQLTTRLFKKLIKQIEDSIDVGTRITHQDLAKKVEQSLENDKQKVMKEIGLQDGLYDFAYTPIIQSGGNYQQVDGPNKDYLSSDVIIIQLGTQVNEYNTNCIRTLFINPTEIQKKLYNAILEVQSKIITLMTIGVSLNVVFKESLQLLQYKLQELNLQNLQLPTSFGYGIGLELKESCLTINEKSTHVVTKGEVYFVNVSLENVQNGQKNITYTVQVGDVIVITNGATTITTQQIPKAYKQISYQLQEEDEPERKPAPVQTDKDKPIRARPRNQQIQIQRENEKQRQIHQEKLAKDKQTELEQRLEQDQFVQNQQEVKALELDKLLCYQRPEQYPKELQKGQIYIDNQKCALLVPLMGTHIPFHVSCIKNVSKIDEGKMGSSIRINFFTSETTAGQIQFPKVDGETIFIKELQYRSKKSDRPQNLILQIKSLQKKVKTEQQVEREKQNVGEMEPLILNKGGRKPIFKDLKVRPTFGSGKAAGILEVHTNGFRYIHSNKEQLDIVFKNIKHYIYQSPEQDIIAALHFHLHSPIVLGKRKTHDVQFYCEVGGAVEHLEGRKKTNRNDEDEIEEEERLRMHRRKMAKEFEVFIKTIEELGADYKISFEKPFRDLGFEGNWNRARLFLQPTRDTLMNVVESPFFILTLNEVEICCFERIIPGIKSFDLVFVFKNYDKQVLRIESIDIKDLEGVKNWLDRMNLLFFEVGQNLVWKNVLGQIQKDIPGFVQDGGWTNILAESEEEGDEEDDPEAGDSEFSPGESGDDGDDDSDFTEDDEDGDDDGDDDDDDEDLSDVLDLNKISDQDEDDEDEDSDSDKNRRKANSRPQQKPQHKPQNKPQGKPQQSVQPHRSNQPQKRQPP
The following text describes a protein:
Function:
Binds preferentially double-stranded DNA. Confers sensitivity to salt and drought stresses.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol.
Sequence:
MKGAKSKTETRSSKLSVTKKPAKGAGRGKAAAKDPNKPKRPASAFFVFMEDFRETFKKENPKNKSVATVGKAAGDKWKSLSDSEKAPYVAKAEKRKVEYEKNIKAYNKKLEEGPKEDEESDKSVSEVNDEDDAEDGSEEEEDDD
The following text describes a protein:
Function:
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Subcellular Localization:
Cell membrane. Late endosome.
Sequence:
MRVEEVRERFPLHFAVWNRDLEGLVTILNDRTDVQIDSVDPRGRTPLMLAVTMDQEEIAKELLKRGANADAQNKDMWSVSHEAIATGNGLLAKEVIMHRDYQRSLRVAADMKQHLDKLKESPDFYAEMSWEFASWVPFVSKLCPSDTYKIWKRGSSVRIDTTLVGFEGHSWQRGSQSFIFRLEDEVNPQLILIDHEAGSATIQSLVADETLGYFEPTEDATFLRMTSPISTTYIDIEKIGFERSKGGILSWIGASEKKEKVAGYDCKVFNASNVELVTKTRSEHLSEADRARFKQDENSNPLSSILNMVRTETGGVEGTAEHVGEPDLIEYFDEEATMKRDIGRQRNVMRKSNSFKATLWLAEQYPLCLQEQVAPIVNLMSSSSAHFSRLNTFMRMQLPAGFPVKIEIPLFHVVSAKITFGRINEPGQFVTPLPAGATVPSGADSTDGVPLLAADGASPAVEIDPRVFDIPDGYRTLDDRSSSMLWWPDEGGSDGGATTGAPARRGASRYSAQQQEDMLLQLAIEQSLLENAAPSGGRRDEVEGCPVVPPSLSRMRIRCWSWRLGEHQGGPSTSSALDDIPDLAPSPEASPSWARRDLTAGEYLRVAEREGWEEERDRRPVRSVHEEEMELALKMSLEAAEEDEKRRRERRERGVSPEEDDDEVMRRILELSMTEK
The following text describes a protein:
Function:
May be involved in osteoclast differentiation.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MAFLTKKKKFKFQTSFNLEELTAVPFVNGVLFCKVRLLDGGDFVSQSSREEVQENCVRWKKKFNFVCKMSANSATGVLDPCVCRVSVRKELKGGKTYSKLGFADLNLAEFAGSGSAARCCLLEGYDTRNTRQDNSILKVNIGMSLLSGDPCFKTPLSTVKTVSPPGQDSSLQMTCKGEGTVRSAGGTVRQNRSRQAMLSSGVFDETEQNLSSPEETPHSGHSRNSSQASQQSKISGHSSEHSRCSSMSDLTHRRNTSTSSSVSGGLSLTAEGTEPERDVKPEKPPRPIRPPLHPDRHSRRKKDSVESQPTWVDDTRIDADDIVEKIMQSQDFSDVSNNEDSHLRLFVSRDGSTTLSGIQLANRISAGVFEPVMIEIR
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MIETSKRSRIINKINNVVISDYKGAIFVWGPKSTGKYTTIKHVLESNSRIYCEADCNEHYSTASLFRSLLSTLRNINKFGRRKPINYDDDDEYINNDINKDNEEDNNNNNNNNNNNNNNNNNNNNNNNNNNNDGYDDGYDDDYDYKDKSLNERIELLKINDLSKEFNNMIIKSQIYSKKIPATSIPSVSEMVQVLYEKASTNETISIILRHSEKLMKFEGEFFYSLFKIEEFTDHPVCLYLLSEIPTERILSTGKEFKPIRNIHFPQYEPNEICSIVLNFKPNFSIINYNQNNNDSNNSNNNNNNNNHLKLKEEDNIKLYNKLVELVVRVFHTTTRDIIDIIFVCHNLFPNYIEPIYNGTCGVEDSDSILYQNIESKIVKSLRNITEKDEIVLEDQKRQQETYQIYPPQQVPQQQKQQEKEKEKEKGRQLASYSDAKNIPYHMKIVLISCFLASSFSRNKDKLLYTKEAVKRQSLSNEKTTGSKWFHFQRAREIGYKLFPSEKKALFQESIFKSLASLKYLETISSIEPAFTYKFKCTRRVHLEFIKQISASINFKIDTYLEAAQFQIISK
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease RIM13 via VPS32 to its substrate RIM101 (By similarity).
Sequence:
MSNFLPIPTKAATPLPSFAKHLLDYISAHFRDTHSEAFRKDVDVLVGMRKDWVEAKLEAHPEIIRAFMRYHAQLAFLSTKFPSDINLPFAYYLPFPATFSLSPDAPISLSSLTFERACVLFNMTALYASMAAAERRAEAEGIKRALGYLTAAAGVLEYLITSVLPTLRSELSSPQAAGYDMTESFLGTLKEFVLAEAQECYWQQAVLQGTYKNGLIGKLSMKVSEYYKAALASMNGTDYPSSSYFPLNWTAHMNVKQMHFEAAAQFRLSQEDLEKSRYGEEIGRLKVAESLAKKGLDAARKGVADSVVSDLKQLHAAIKSSLERAVRDNDLVYVQPIPPANQLAPIVGVGMVKVNVPAEVAEPVAWLMGGKAGMEPLFSGLVPYGVHLALSIYDDRKDTLVRDLDGKREELDGLAASTLQSLNLPGSIQALDRPVGLPPSLLKKSEEVASSGGIERIRSLLDEVNRLAHANVQSLNEAMDILDQEATENESLIARQPELQQTRQPSHVANQPLIQMAEQYEATIKQAGGSDATVRAKWEEWARLVGILAAGEMEMEDYVPGTTSPSGSLPPSVRPLRASLEELDDRIAHRARLVREARQISAADDIRPEVLKEAAKLAHGGSGDVKTEWFEDLFEKGLEKYMGVKREMDEEVAKHDELLEQIRTQNESFLSERKDDPIIKERERRLQDMDLAYWKWREIVDNAEEGIKFYNSFAEMLHGFKAACGQFLNTRRIDVGQMTTQFQQQMNVSEPQQQPEPRYQSPSPQSFQPSFSPSPSHFQPSAPSSFSSSPVRSPAPSAPARRESPPKTLSFLPHPSSSAWQPASVDFLPPPPPPPILRSGGIQSQPKVAPPVTPSITAIRDQTQGTPRRMTRAAAAAAERDEATERNKYSSGGPRRKGGGVV
The following text describes a protein:
Function:
Component of the cleavage factor IA (CF IA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation. Associates with HRB1/CF IB to form the cleavage factor I (CF I) complex. CF I is required for correct positioning of a larger protein complex, the cleavage and polyadenylation factor (CPF) complex, which contains the catalytic subunits executing mRNA cleavage and polyadenylation. CLP1 mediates interactions between CF IA and CPF factors. CLP1 is also involved in maintaining the CF IA interaction with the C-terminal domain of RNA Pol II largest subunit via PCF11, which links pre-mRNA 3'-end processing to transcription termination.
Subcellular Localization:
Nucleus.
Sequence:
MASLPGIDEHTTSEELITGDNEWHKLVIPKGSDWQIDLKAEGKLIVKVNSGIVEIFGTELAVDDEYTFQNWKFPIYAVEETELLWKCPDLTTNTITVKPNHTMKYIYNLHFMLEKIRMSNFEGPRVVIVGGSQTGKTSLSRTLCSYALKFNAYQPLYINLDPQQPIFTVPGCISATPISDILDAQLPTWGQSLTSGATLLHNKQPMVKNFGLERINENKDLYLECISQLGQVVGQRLHLDPQVRRSGCIVDTPSISQLDENLAELHHIIEKLNVNIMLVLCSETDPLWEKVKKTFGPELGNNNIFFIPKLDGVSAVDDVYKRSLQRTSIREYFYGSLDTALSPYAIGVDYEDLTIWKPSNVFDNEVGRVELFPVTITPSNLQHAIIAITFAERRADQATVIKSPILGFALITEVNEKRRKLRVLLPVPGRLPSKAMILTSYRYLE
The following text describes a protein:
Function:
Mediates a strong voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Contains a central ion-conduction pore surrounded by four voltage sensors which form the voltage-sensor paddles that move in response to membrane voltage changes through the fluid membrane interior, each voltage-sensor carrying their four positive charges across the membrane. It is thought that the S4 arginine residues move through the membrane's electric field to open the pore.
Sequence:
MSVERWVFPGCSVMARFRRGLSDLGGRVRNIGDVMEHPLVELGVSYAALLSVIVVVVEYTMQLSGEYLVRLYLVDLILVIILWADYAYRAYKSGDPAGYVKKTLYEIPALVPAGLLALIEGHLAGLGLFRLVRLLRFLRILLIISRGSKFLSAIADAADKIRFYHLFGAVMLTVLYGAFAIYIVEYPDPNSSIKSVFDALWWAVVTATTVGYGDVVPATPIGKVIGIAVMLTGISALTLLIGTVSNMFQKILVGEPEPSCSPAKLAEMVSSMSEEEFEEFVRTLKNLRRLENSMK
The following text describes a protein:
Function:
Acts at 2 distinct steps of magnetosome formation; required for correct localization of proteins to the magnetosome while the protease activity is required for maturation of small magnetite crystals into larger, functional ones. The 2 functions are separable by mutation. Probably cleaves at least itself, MamO and MamP; cleavage requires the putative transport domain of MamO (Probable). Involved in localization of some proteins (at least MamA, MamC, MamF, MamI and MamJ) to the magnetosome.
Miscellaneous:
MISCELLANEOUS: This bacteria makes up to 20 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)); MISCELLANEOUS: There are 2 paralogous genes in the genome; limE (amb1002) has a partially overlapping function with MamE, while mamE-like (amb0410) does not seem to play a role in biomineralization; MISCELLANEOUS: Expression of just the minimal mamAB gene cluster (amb0961 to amb0978), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles; MISCELLANEOUS: There is a third MCR motif in the M.gryphiswaldense strain MSR-1 MamE ortholog.
Subcellular Localization:
Magnetosome membrane; Single-pass membrane protein.
Sequence:
MAMFNGDVEDGGRGDASCGKDLKRYLMLMGVVALVVLFGAFIYRQSSGGLRLGAMLEQMGRGTGPAVNVPVQQGGPSAAVNPAMSVPAGARVAPPSAAGAIATMPPMVDFGPAPIGAGGPFSSVVTLLRNSVVAVTASSANGQAMPDPLGLANPDGLPHFANPATRSVENIGTGVIVRNDGFIVTNYHVVRGANSVFVTVQDDVGSTRYSAEIIKMDEALDLALLKVAPKTPLTAAVLGDSDGVQVADEVIAIGTPFGLDMTVSRGIISAKRKSMVIEGVTHSNLLQTDAAINQGNSGGPLVISNGTVVGINTAIYTPNGAFAGIGFAVPSNQARLFILDEVGWLPTSTAEGASMGLVAMQRPMGGGVGAAGPAIFAGTRAPHTDGRQNMDCTTCHDLIPAGNGRPAPMMPIAAPIPPPPIPMGAVSPHTDGRQNMNCANCHQMLGGAAPIAAPGLGGGAYRFAQPPGSLAINIQGPRGGQSTAAGTGRVTLLGAALTPMSQRLGAQTGVPVGRGVFISGVTPNTPAATAGLRPGDVLLKVDGRPVRLPEEVSAIMVEMHAGRSVRLGVLRDGDVRNMTLVAGPAGLAAAAVQAPAIADMAQPPMGGMAPTAPGMVAVPGGPAVMPKPPTEFNWLGMEIETFQAPRPITGVPGAVPVPGAKGAQVAEVLVGSRAAVAGLQANDLILEVNNRPVAGPARLDAAIKGATNAGQQILLKVNRNGQEFWIVL
The following text describes a protein:
Function:
Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MDRMRAGMRQRLAQRQGEPAVDPAAEDSEDASGSGSDEDPDAPMDRRAARRAARREAAAADRAAADAKMNKRSAYEERRAKREAEREAQEAAQEEEMRRAAEERARREEEEAAKWMGQISVEEQGEDGDESGAAAESLLAAFVDFIKGRKTVPLEALALQFGLRTSEAIDRIRQLEEAGRLTGVMDERGKYIYISREEMGAVADYIRQRGRVAIGELAARSATLIDLEPRPEDGGAAAAAAGGRGAAGGGLDFEQLLAAA
The following text describes a protein:
Function:
Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. The RFC4 subunit probably functions as a scaffold on which the other complex components can assemble.
Subcellular Localization:
Nucleus.
Sequence:
MQAFLKGTSVSTKPQLTKERGISSSAGSSGETKKVKPVPWVEKYRPKCVDEVAFQEEVVAVLKKSLEGADLPNLLFYGPPGTGKTSTILAAARELFGPELFRLRVLELNASDERGIQVVREKVKNFAQLTVSGSRSDGKPCPPFKIVILDEADSMTSAAQAALRRTMEKESKTTRFCLICNYVSRIIEPLTSRCSKFRFKPLSDKIQQKRLLDIAEKENVKIGDEEIAYLVRISEGDLRKAITFLQSATRLTGGKEISEDVITDIAGVIPAATIEGIVTACHSGSFDKLEAVLKNLIDEGHAATQLVNQLHDSIIEDENLSDKQKSIITEKLAEVDKCLADGADEHLQLMSLCATVMQQLTQNC
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in fructose transport.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.
Sequence:
MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDLKTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAAAGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALISVSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTDFNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA
The following text describes a protein:
Function:
E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for proper localization of ATG8 to the preautophagosomal structure (PAS). Likely serves as an ATG5-recognition molecule.
Subcellular Localization:
Cytoplasm. Nucleus. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MSFKSQLLILAQKLSKGGISCELIEFDECILKLEWHTELLDKNDSLLYEQEEDDILSLMNPMITMHAWIRDSPSFEVPQFFFQPYANGSDPLTKMEQIFELLEGSSQNLAYDALAIGDCPGTVGIAWYIHPCRTRDYFEMLQIDKEDPKYLSLWLLYIHQVLSPLTQPIIKAVDDAEKS