lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in transport of phospholipids.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MASASSTNSISTTKYNLFTFLPKSLFEQFRRVANIYFLLSAGIAYSPLAAYSSSSAIAPLVIVLVATMIKEAIEDWRRNQQDTEVNNRTTQVFFQQAQAQAGDGDGDAARGGFRDAKWKDIRVGDIVKVHKDEFFPADLVLLSSSYEDAICYVETMNLDGETNLKLKQSLEVTSASLPDDDSFRGFAGAVVRCEDPNAHLYTFVGNIEIDGQQHPLSPQQLLLRDSKLRNTDFVYGVVVFTGHDTKVMQNSMKVPSKRSNVEKKMDRVMYLLLFSLIVISVVSSVVFGVATGDDLQDGRMKRWYLRPDDTEIYYDPNNAAVAAVLHFFTAIMLYGYFIPISLYISIEIVKLLQALFINNDIHMYHHETDTPAHARTSNLNEELGQVDTILTDKTGTLTCNSMEFIKCSIAGTAYGRGITEVERAMARRKGSPVIADHDNNNMDKGNNNGIQQQSSSDSEGNSKPAVKGFNFVDERVMGGNWVNQPGSGVIEMFFRLLAVCHTCIPEVDQESGKISYEAESPDEAAFVVAARELGFTFYKRTQTGVSLRELDPSSGKQVDRSYKILNVLEFNSARKRMSVVVKNEEGKIFLFTKGADSVMFERLSGSETAYREVTQRHINEYADAGLRTLVLAYRELKEDEYAYFDGKFTAAKSSVSTDRDEKIDEAADLVERDLILLGATAVEDKLQKGVPECIDKLAQAGIKIWVLTGDKMETAINIGYACSLLRQGMKQITITLETADVIALEKGSDKAALTKASKDSVARQINEGKKLVNASSGESFALIIDGKSLTYALEDDTKDMFLDLAVGCGSVICCRSSPKQKALVTRLVKTGTGKVTLAIGDGANDVGMIQEADIGVGISGAEGMQAVMASDVSIAQFRFLERLLLVHGHWCYSRISSMICYFFYKNITFGVTLFLYDAYTSFSGQPFYNDWAMACFNVFFTSLPVIAMGVFDQDVSARFCLKFPMLYQEGPQNLLFQWRRIIGWMLNGVASAVIIFFLSTASLQHQAFRIGGQVTDMATLGATAYTCIVWAVNLQMYITVSYFTLVQHVCIWLSIALWYVFLPVYGAITPSFSTTYYMVFVEALAGAPSYWVVTLLVSAAALVPFFTYAVVKSWFFPDYHNRIQWLRHREKAKAHPDPETSADVELSQVLRQFSVRSTGVGVSARRDATAVLRRLNSTTQHADYYSQSPAPGVVVVTTDR
The following text describes a protein:
Function:
Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration (By similarity).
Subcellular Localization:
Vacuole lumen. Cytoplasm. Note=Is released from the vacuole to the cytoplasm during stress conditions like oxidative stress or stationary phase stress.
Sequence:
MKYSILAILAHLLTNIKATQEVFTLSDLPPDSCPIDSPISCSKNAQELENVNSCCYESPAGVILLTQFWDYNPATGPDNLFTQHGLWGNMCSYGYPQFCDPSLEINPNGEIIRSIIVDQFGDEELYNNMSYSWKDYHGKDSSFWAHEYNKHGTCFSTIKPSCYLSNTPKNQNLYDFFRIAIGLFNKLPTYDWLAEAGIVPTNSKTYSLSEIQSALNDKFGANVFIKCDYNHAINEIWYYHHVKGSLLQHNFLPIDSVAHTNCPSTGIKYPPKGKVAHPTLTTKTTTGTSTTIHNPTGIPARSYVHLSGKSGCLISNGKWYTSGTCATYHFKKTIDDSNIEIRSSKGICGINGNEEFTCSRAVSGGTDFQIKDGKIGYQDKFDWCFGSTTGSGSTAQTSVKLADGSCDSFQLLI
The following text describes a protein:
Function:
Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells.
Subcellular Localization:
Membrane; Single-pass type II membrane protein. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
Domain:
The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.
Sequence:
MPEAEMKEEAPEAHFTVDKQNISLWPREPPPKQDLSPVLRKPLCICVAFTCLALVLVTSIVLQAVFYPRLMGKILDVKSDAQMLKGRVDNISTLGSDLKTERGRVDDAEVQMQIVNTTLKRVRSQILSLETSMKIANDQLQILTMSWGEVDSLSAKIPELKRDLDKASALNTKVQGLQNSLENVNKLLKQQSDILEMVARGWKYFSGNFYYFSRTPKTWYSAEQFCISRKAHLTSVSSESEQKFLYKAADGIPHWIGLTKAGSEGDWYWVDQTSFNKEQSRRFWIPGEPNNAGNNEHCANIRVSALKCWNDGPCDNTFLFICKRPYVQTTE
The following text describes a protein:
Function:
Secreted effector that enables the plant pathogenic fungus to manipulate host defenses for successful infection. Binds chitin but not cellulose or xylan. Chitin-induced polymerization of homodimers forms a contiguous Mg1LysM highly oligomeric super-complexe that is anchored to the chitin in the fungal cell wall to prevent hydrolysis by host chitinases.
Miscellaneous:
MISCELLANEOUS: In plants, chitin acts as a microbe-associated molecular pattern (MAMP) that is recognized by lysin motif (LysM)-containing plant cell surface-localized pattern recognition receptors (PRRs) that activate a plethora of downstream immune responses.
Subcellular Localization:
Secreted. Secreted, cell wall.
Domain:
The LysM (lysin motif) domains are small globular domains involved in binding chitin in eukaryotes. Mg1LysM contains one LysM domain.
Sequence:
MQFTALVAALLSVAAVQAQRNPITITPQFDCGATNSQQYVARSGDTLTKIAQEIYHDVVGVCDIARANNLADPNRIDAGTPYTIPINCQTYDRNSCL
The following text describes a protein:
Function:
Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.
Subcellular Localization:
Cytoplasm, cytoskeleton, stress fiber.
Sequence:
MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQLLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEMLQKKQNVLRSEKETRNKLIESDLNSKMQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEAGKKPETFVNHSNSESKSSITEQIPAPAQNTFSASSARRFSSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPLRDRGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNETPQTIAPSTYVSTYLKRTPHKSQADSIAEKTADNVSSSTPLCVITNRPLPSTANGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPCEKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHRLRCPTQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSKTTTNTTTAKEMDKNENQEADLDEQYSRRLSVRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVTQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTELKSDNQRLKDENGALIRVISKLSK
The following text describes a protein:
Function:
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template. Shows poor RNA-dependent ATP hydrolysis and inefficient DNA-RNA unwinding activities, but exhibits robust and fast transcription termination, which suggests that the transcription termination function of M.tuberculosis Rho is not correlated with its helicase/translocase activities and that these functions may not be important for its RNA release process.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Domain:
Contains an extra N-terminal domain, a S1-like RNA-binding domain and a conserved P-loop NTPase domain.
Sequence:
MTDTDLITAGESTDGKPSDAAATDPPDLNADEPAGSLATMVLPELRALANRAGVKGTSGMRKNELIAAIEEIRRQANGAPAVDRSAQEHDKGDRPPSSEAPATQGEQTPTEQIDSQSQQVRPERRSATREAGPSGSGERAGTAADDTDNRQGGQQDAKTEERGTDAGGDQGGDQQASGGQQARGDEDGEARQGRRGRRFRDRRRRGERSGDGAEAELREDDVVQPVAGILDVLDNYAFVRTSGYLPGPHDVYVSMNMVRKNGMRRGDAVTGAVRVPKEGEQPNQRQKFNPLVRLDSINGGSVEDAKKRPEFGKLTPLYPNQRLRLETSTERLTTRVIDLIMPIGKGQRALIVSPPKAGKTTILQDIANAITRNNPECHLMVVLVDERPEEVTDMQRSVKGEVIASTFDRPPSDHTSVAELAIERAKRLVEQGKDVVVLLDSITRLGRAYNNASPASGRILSGGVDSTALYPPKRFLGAARNIEEGGSLTIIATAMVETGSTGDTVIFEEFKGTGNAELKLDRKIAERRVFPAVDVNPSGTRKDELLLSPDEFAIVHKLRRVLSGLDSHQAIDLLMSQLRKTKNNYEFLVQVSKTTPGSMDSD
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Sequence:
MSGFTTFHAMIRLRPLTIPIRIFIRNVSLSSGFRHQKYKRLDYPKAPTLLRDPPPEVRAVPQTPPETFSVKRQGRNKAGRKQTTEMYTFVSQKDALEFELAPSAVLRQTIEKRLASLSQEQRELKAEMETQIARAGGVFAVRKGLVPGIYLHWDKVVRETGKMSQSEWKKLETVQEAQEWMGMYHVSPEDVCYDPFASRISFLEHLLSDEAKLEPEKKRWFAVKKGRQPGVYSNWEEAADQVIGYSGAVYASFSTDKQACKFLGMSKKEYFEQLKQDPTETDKEMIRQKRLADEQLQAYKRERDRIKFSQYAEAKMYIAPPDGGSPNRVKQLLTKCLQIQAEINKMVSLDKMRKFHMQDIFDELDQMTEEEKQECLESLDNSHLVDAYNVFNNPEYWDFYREYLLTKENYLGYESTTCSKGRGDTLFKSEFRECGTTKSTTEELAATEVSQWRQKNETSVENDTVKLDTSSEGFFSSTQELSERTEDTVDKKLTQRQKRDSKRATLKALDKSISENIAAPDDVAIGIKENGTVRNQAKKTTFENWLDGFSEAEKHKPASKITLTGHFKNATPQMRREMLKARHETKMELVARTADPSTTVTLDMLAGLTCNCGEPVFVRNRDSSAAAPLIPRRQLYLSTNRYKNLHGDSGWTNHTFKHKQADFDINTTSFRDHHDHKLLRAFETNWRIMFNSLSKQLGPIAANHAGRYDDVEANVVYTDGSHNALPSPLLYNAGAAGWGVHFEKGLMPDACGRVPGEQTPGRAEILAMVMAIRIISRHMTYRSQKWEIRTDSLWTLRLLEHGWEGLEPTERMRSHPNYYLIKRLRALLYENQNISLRFIRSQHMHSGARIADKLAKKGARKKYSETAEQYGTDDEDIFIHDPALSAFFPSATVPSNLRSSMWTDNKE
The following text describes a protein:
Function:
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner; Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils; [Isoform 2]: Shows negligible inhibition, in vitro, of thrombin and tPA and no inhibition of factor Xa, in vitro.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Produced by alternative exon usage of exon 3b instead of exon 4.
Domain:
The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.
Sequence:
MKHSLNALLIFLIITSAWGGSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFHKENTVTNDWIPEGEEDDDYLDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRS
The following text describes a protein:
Function:
Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization.
Sequence:
MDQKMINDLKEQVFQTNLLLPKYGLVIHTWGNVSMIAPNRQFFVIKPSGVSYDKMRAQDMVVVDLDNNVLDTNGLKPSSDTPTHALMYKHCPDIKAIVHTHSTFATSFAQADKPIPCLGTTHADNFFGPIPCTRALSDSEINGAYEHNTGLVILEHLKNNQVDVNACAAILVKEHGSFVWSNKNGKDAVDRALTLEQVAQMALYTQMINPHMKEANPALQQKHYNRKHGKDAYYGQDTKQED
The following text describes a protein:
Function:
Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Recycling endosome. Cell projection. Cytoplasm, cytoskeleton.
Domain:
Exists in a closed and an open conformation due to interaction of the C-terminal coiled-coil domain with an N-terminal region including the calponin-homology (CH) and the LIM zinc-binding domain. The conformational change is regulated by RAB13 and RAB8A. Adopts its closed form upon interaction with RAB8A and interaction with RAB13 causes conformational change from closed to open.
Sequence:
MAAIRALQQWCRQQCEGYRDVNICNMTTSFRDGLAFCAILHRHRPDLINFSALKKENIYENNKLAFRVAEEHLGIPALLDAEDMVALKVPDRLSILTYVSQYYNYFHGRSPIGGMAGVKRASEDSEEEPSGKKAPVQAAKLPSPAPARKPPLSPAQTNPVVQRRNEGAGGPPPKTDQALAGSLVSSTCGVCGKHVHLVQRHLADGRLYHRSCFRCKQCSCTLHSGAYKATGEPGTFVCTSHLPAAASASPKLTGLVPRQPGAMGVDSRTSCSPQKAQEANKARPSAWEPAAGNSPARASVPAAPNPAATSATSVHVRSPARPSESRLAPTPTEGKVRPRVTNSSPMGWSSAAPCTAAAASHPAVPPSAPDPRPATPQGGGAPRVAAPQTTLSSSSTSAATVDPPAWTPSASRTQQARNKFFQTSAVPPGTSLSGRGPTPSLVLSKDSSKEQARNFLKQALSALEEAGAPAPGRPSPATAAVPSSQPKTEAPQASPLAKPLQSSSPRVLGLPSRMEPPAPLSTSSTSQASALPPAGRRNLAESSGVGRVGAGSRPKPEAPMAKGKSTTLTQDMSTSLQEGQEDGPAGWRANLKPVDRRSPAERTLKPKEPRALAEPRAGEAPRKVSGSFAGSVHITLTPVRPDRTPRPASPGPSLPARSPSPPRRRRLAVPASLDVCDNWLRPEPPGQEARVQSWKEEEKKPHLQGKPGRPLSPANVPALPGETVTSPVRLHPDYLSPEEIQRQLQDIERRLDALELRGVELEKRLRAAEGDDAEDSLMVDWFWLIHEKQLLLRQESELMYKSKAQRLEEQQLDIEGELRRLMAKPEALKSLQERRREQELLEQYVSTVNDRSDIVDSLDEDRLREQEEDQMLRDMIEKLGLQRKKSKFRLSKIWSPKSKSSPSQ
The following text describes a protein:
Function:
Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).
Sequence:
MSRRHLKQGEANPTVKPDVLRLYSMGFCPFAQRALLVLAVKGIDYELVNCNLNHKPEFLLERNPAGTVPVLEFQGNIVTESLVICDLLEDLFPDKPLKAKDPFQKAKNRLAVGKFDSIVSLFYKVGYNPDDADAKETLRKSMKEYQAFFTAKKTNFFGGDQWGMVDLMVWPWIERMHVLGAVIIDDFVPEFKAWVDRMGTVPAVQACRISKEKLSEMYTGYFARNAVYD
The following text describes a protein:
Function:
Transcription factor required for smad1 and smad2-mediated responses to TGFbeta during mesoderm induction.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAENAGVASKSALQAVFPSSPSLPSLLVSTSSHHGSPFAIGRPGQQSQSSSSNGGGSGGGGGMRLEAVMENLQRQQAARLALEEKLRQEKERELRCMVESRIQQQALAIRQYQAAVRAAAAAAVATSPPSLSATNSAPTGTAISHSRPPLIFPRSQGKRSEEEEEEQKHESEGEEGMDCDEEELDDEEGEEDEDGETASNMQKQGSPSKGGLSVGQSQVPNPSNPGQSQALSPSGQTGHHEWTYEEQFKQLYELDEDPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLYSLYRLVTEKGGLVEVINKKIWREITKGLSLPTSITSAAFTLRTQYMKYLYPYECDKRGLSSPGELQAAIDSNRREGRRQSFGSGLFSYSPAGTPSVLASPKINMASLSLSTHNGGQINHLTPIKKEDGAPTPGAPHRVGIPIALASHHGAVQVMQAAALEQLREKLDSGEPPEKKMSLMAEEQRIMQQAIQQNLLAMAAQLPMNIKINSRDDRQEAQMNLSATSISSINMSIEINGVVYAGRWAAAPPALIAGNPINDSQAQVDALPSLLTALL
The following text describes a protein:
Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Sequence:
MYNLLRKIALTLYRPFMKEKMKTFINKRLSQDFSDLKDEEYIWIHCSSVGEVNLSEDLVKKFYSISRKNILISVFTDTGYENAVKKYSDKKKIKVIYFPVDDKKKINEILNKIKLKLLVLVETELWPNLINEVNEKNSRIIVVNGRISDRSYPRYKKLKFLLKSMLQKIAFFYMQSEIDKERIVSLGAIKEKVENVGNLKFSISLEKYSDIEKKEYRKFLNIGDRKVFVAGSTRTGEDEIILDVFKRLKNYVLIIVPRHLDRLPKIENLIKENNLTYVKYSDLENNTSTGKENIILVDKMGVLRKLYSISDIAFVGGTLVNIGGHNLLEPLFYRKTVIFGKYTQNVVDIAKEILRRKIGFQVENVEEFVKAIETIENEKNSDEEINSFFEENRLIALNIVKKENLIMNNIKEEAKDLWKHFFHSEKSNYNMYMYKLLDYPEYIMYDNDVMKEKKSKWSEYFGNSDQIAVEIGTGSGNFIYQLAERNPNKNFIGLELRFKRLVLAAQKCKKRNIKNVAFLRKRGEELEDFLANNEISEMYINFPDPWEGTEKNRIIQERLFKTLDKIMKKDGMLYFKTDHDVYYNDVLELVKTLDNYEVIYHTSDLHNSEKAENNIKTEFEQLFLHKHNKNINYIEIKKIV
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MDQLKGIGMQVFYTILKQHRRKLRPEMRILGDAYVKEEFRQAHQKANQEQYIEFLKRWAIYIEELDKSKQIGRDLTSEEKALLNEDQIDNLAKLKEFSKQQKSE
The following text describes a protein:
Function:
Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
Sequence:
MREVLYMTDKKNLRTPIVCVMGHVDHGKTTLLDKIRGTAIVSGEAGAITQHIGATEVPIDVIVNKLGDPKLRDRFMVPGLLFIDTPGHHAFTTLRSRGGALADLAIVVVDINEGFKPQTYESLQILKRFKTPFVVVANKIDRIGGWASQKDMPFAATFKKQSPDVQGRLETKLYEVIGELYNQGFAAERYDRVTNFQKTLGVVPASAVTGEGIPDVLMVLLGLAQKFLEANLQYSAKNPGVGTVLEVKEEKGLGATLDVILYDGTLKKGDTVVIGSLGEPIQTKVRALLKPRELSEIRYESKFKQVSEVTAAAGVKISAPGLDGALAGSPIRVATEETLGEIVAQVKSEIDEVRIDTGSVGVMIKADTLGSLEALVHEFQKDEVPIRKAEVGDISHRDAVEASTVEDPLYSVLIGFNVKVHPDARDFLQESTVKVFTSDVIYRLVEDYQKYVKEQQELAEKKIFETIIRPGKFKILPGCVFRQSKPAVVGVRVLGGVVRTNADVMLENGNVVGKIKGLQSEGENIPSAKVGKEVAMAIEGATVGRQIKEEDVLYINVPERHAKVLEHEIYDSLSTDEKETLDIFLTLKRKNNPFWAK
The following text describes a protein:
Function:
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Subcellular Localization:
Cytoplasm.
Sequence:
MFVLVNLKAYPCDPVAIAEAAADVAETTPATIAVAPQPADIGRVADTGATTYAQHVSPTEHGSHTGSVLAESVADNGAVGTLLNHSEHRRRLADIDGSVAAAERAGLDTVVCANNPAQVAAAAALGPDAVAVEPPALIGTGTPVSQADPDIVSDAVAAAEAVDPSVDVYCGAGITTGEDVVSAGDLGASGVLLASGVAKADDPRAALADLVAPL
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MDILVNLQAFLATADAAGFSAAARKLNVSTSVVAKRVTQLETRIGTPLFHRSTRQLRLTDAGQRYVHRARGVVTDATDLLSRMGEKGHDLVDHLRIKAPTSLTVARLADAFSAFQTQNPRLKLEIVLIDRPVDPVTEGFDIAIGAFPHSFGGVVDEPLCALKRLLCASPAYLKKHGTPKHPRDLVEHRCLSFLPTGPEWIFDGPRGRISIQVSPLLSSNEGHVLARSAIAGNGIALISHYLVADALRDGTLKPVLRDFPIPELWVKAAIPERRRNAAAVQALLTLLKTSLASSL
The following text describes a protein:
Function:
Probable protease that might be involved in processing fibril precursors (Probable). Upon overexpression of the endogenous six-gene locus (fapA-fapF), cells form large clumps during liquid growth, make large amounts of biofilm and produce amyloid fibrils.
Subcellular Localization:
Periplasm.
Sequence:
MRTLILSLLLLVDLTTQAATLGFPALPGGGLVYKQVQSIRERRFADLVEQKTDFSCGAAALATILEKAYGAPLDEQAVIQGMLAHADPEIVRTQGFSMLDMKRYVESMGMRARGYRIEAAQLEQLKIPAIVLMEIRGYKHFVVLQRTQGEYVYVGDPALGHKRYALTEFAKGWNGIVFAVIGQGYDRGNPLLTPPEPLTARNRLDRFKPVRDAELMEFGFIQSDFF
The following text describes a protein:
Function:
Involved in the biosynthesis of the nonproteinogenic amino acid monomer (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of vancomycin and teicoplanin antibiotics. Catalyzes the syn-addition of a water molecule across the double bond of a trans-2-enoyl-CoA thioester, resulting in the formation of a beta-hydroxyacyl-CoA thioester. Physiologically, DpgB could act as a dehydratase, facilitating the aromatization of the DPA-S-DgpA or DPA-S-CoA intermediate.
Sequence:
MNGELVLRLDGARPLSPASVEELSALCDRAEDDREAGPVTVHVTGVPSAGWTAGLTVGLVSKWERVVRRFERLGRLTIAVASGECAGTALDLLLAADLRIVTPGTRLRLAPVGGSTWPGMSVYRLTQQAGAAGIRRAVLLGTPIEVDRALALNLVDEVSDDPAKTLAGLAEAAAALDGAETAIRRQLIFEDGSTTFEDALGAHLAAADRALRREATS
The following text describes a protein:
Function:
Acts as a ligand for Notch (N) receptor. Essential for proper differentiation of ectoderm. Delta is required for the correct separation of neural and epidermal cell lineages. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta. O-fut1 also has a role in modulating the interaction.
Miscellaneous:
MISCELLANEOUS: Separation of neuroblasts from the ectoderm into the inner part of embryo is one of the first steps of CNS development in insects, this process is under control of the neurogenic genes; MISCELLANEOUS: Notch and Serrate may interact at the protein level, it is conceivable that the Serrate and Delta proteins may compete for binding with the Notch protein.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MHWIKCLLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCLKHYQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIVEAWHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGCEHGHCDKPNQCVCQLGWKGALCNECVLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPCHQGICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSGKCICPAGFSGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSVTFDAHQYGATTQARADGLTNAQVVLIAVFSVAMPLVAVIAACVVFCMKRKRKRAQEKDDAEARKQNEQNAVATMHHNGSGVGVALASASLGGKTGSNSGLTFDGGNPNIIKNTWDKSVNNICASAAAAAAAAAAADECLMYGGYVASVADNNNANSDFCVAPLQRAKSQKQLNTDPTLMHRGSPAGSSAKGASGGGPGAAEGKRISVLGEGSYCSQRWPSLAAAGVAGACSSQLMAAASVAGSGAGTAQQQRSVVCGTPHM
The following text describes a protein:
Function:
Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (By similarity). During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT). The scavanged iodide can then reenter the hormone-producing pathways (By similarity). Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine (By similarity).
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane.
Sequence:
MFLLTPVLVAVVCILMVWIFKNADGATKRREEEPRARAEARPWVDEDLKDSTDVLQVEEDADEWQESEEEVEHVPFSHTRYPEKEMVRRSQEFYELLNKRRSVRFISNERVPMEVIDNVIKAAGTAPSGAHTEPWTFVVVKDPDVKHRIREIMEEEEKINYLKRMGPRWVTDLKKLRTNWIKEYWDTAPVLILIFKQVHGFAANGKKKIHYYNEISVSIACGIFLAALQNAGLVTVTTTPFNCGPRLRVFLNRPANEKLLMFLPVGYPSKEATVPDLPRKPLDQIMVTV
The following text describes a protein:
Function:
Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity.
Subcellular Localization:
Cell surface. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
Sequence:
NPRPLTPKPVLFPLSHAASLGWGALIVQETLDSPLCFTVTISTFPAIFCYYRPPTDTFPGIKLQSKVRTSAKQTTEETCPSQLDDHTATRRAATDTSPSTQTIHTTAKANPTTTPTTVKSKPATHISRITTATRRVPQTTSAAPTIVASTTLTPRSTSTTPGAGRPTTLTPRAIVTTPPTVGPTTNGITGTESAVSQTVTAAPTANGTGNHTVTETTRAVTTTPDAHNITQTTWLITTTAGPTLAPRPSSAAVGTYRVSNGSRTCVKAVMGIQLIVQDRQMGYFNIDPNVTKASGSCETWKANLLLTFSGGFVNFNFTKDGGSYYISSIEARLTVSSPKVDHHGVKREVQWFKTLVGHSFQCLSAQRVQLGNDLQLQTVNVQLQAFDITRDQFGNADECFSDRNRRAIPVAVSLSIAGLFVVLLVTCLVTRKSPARGYERV
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and cell cycle control. Required for the binding of the NTC complex (or PRP19-associated complex) components to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. Its absence leads to an arrest of the cell cycle, possibly due to the inefficient splicing of TUB1.
Miscellaneous:
MISCELLANEOUS: Present with 784 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPPVPIYVKGGVWTNVEDQILKAAVQKYGTHQWSKVASLLQKKTARQSELRWNEYLNPKLNFTEFSKEEDAQLLDLARELPNQWRTIADMMARPAQVCVERYNRLLESEDSGGAALSTGVTDLKAGDINPNAETQMARPDNGDLEDEEKEMLAEARARLLNTQGKKATRKIRERMLEESKRIAELQKRRELKQAGINVAIKKPKKKYGTDIDYNEDIVYEQAPMPGIYDTSTEDRQIKKKFEQFERKVNRKGLDGNKDKPSKKNKDKKRKHDENEHVEKAALGESTTLTDEYKKPKLILSAPGTKQGKVTYKKKLESKRQKLIEAQATGTVLTPKELLPHDSGQEDNERSNIKSGKQLKSRIRKFLVQMFASLPSPKNDFEIVLSEDEKEEDAEIAEYEKEFENERAMNEEDNFIEPPSQNDAPRVSLVAVPLAYSTLPIPEFKNNPQSAIDNKYNLLVANAINKEPHMVPEDTVDFLKEVESRMQHITQGRTSMKIQFKTAMPPTEVLLESIQSKVESIEQLQRKLQHVQPLEQQNNEMCSTLCHHSLPALIEGQRKYYADYYAYRQEIRSLEGRRKRLQAMLNSSSSI
The following text describes a protein:
Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Sequence:
MPELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRELPSQIIESMGRRGKYLLFYLTDKVLISHLRMEGKYFYYPDQGPERKHAHVFFHFEDGGTLVYEDVRKFGTMELLVPDLLDAYFISKKLGPEPSEQDFDLQVFQAALAKSKKPIKSHLLDQTLVAGLGNIYVDEVLWRAQVHPARPSQTLTAEEATAIHDQTIAVLGQAVEKGGSTIRTYTNAFGEDGSMQDFHQVYDKTGQECVRCGTIIEKIQLGGRGTHFCPNCQRRD