lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK-signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Syd is required for efficient kinesin-I mediated axonal transport.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MENSVGESSEVVYGTHEDSAMVMSEKVQSLAGSIYQEFERMIQRYDEDVVKTLMPLLVNVLECLDSAYQTNQEQDVELELLREDNEQLVTQYEREKNARKQAEQKLLETEDLAEQENKELASRLESLESIVRMLELKHKNSMDHASRLEERESELKKEYSKLHERYTELFKTHVDYMERTKLMMGNSTHSQAGSASERLDVSRSRLMPMMRSTGPVSYGFASLENSTMLDTETLCSEEDSGPDSGPPSLQNEIETKATERVEEVDSATAAPADAMATSSTAKVLQSPTGGGVSGKTTTKKEQRSANTLYQELSFQDDNLESEENEITGAWVHPGDYASSANDNFFGMGKEVENLIMENNELLATKNALNIVKDDLIVKVDELTGEIEILREELNAVILARNKLKAKVTELEEELKKTKAQVKQASSSATDQEEEGDVPMAQRKRFTRVEMARVLMERNQYKERFMELQDAVRWTEMMRASRVETLDKKSKQGIWKFFSNLFSSNDRPTNESPGRLHQRYGGVSAQSQAHGTASLLPAMPEGRMLIGAGNGGIGGGGGGGGGSGIGLGALATGSSAALLRSGHASNILVLSKEPELTQSERAMQRRRDQYRQVRAHVQKEDGRLQAYGWSLPSLKPSNAAGANGGVGSAGGGGVGRPTGSGVPVPVPVYCRPLAEASPHMKVWCASGVNLQGGYTKDGGCIVGAASIFYAKDTTGGGAQITELTGDEATVEPKDLGELLERKLLALGGPASLDADSELSSYVWICTSTHSASTVTVIDAKNPSEVLDSFPVCQNHLLCICTVRGALEMDYAMLENSEVTKSGKMLEKPGESPDDIGKVSYEKVVRSAADSAPTSADEHKATEEAQEAVPPSDTVPEQATEANSDRDLNHNSKAAHEVLDSVDTKDIAIAVDGNDNTIGETTSSPNKPQPETAIEESISSIGPTMWLGAQNGMLYVHSSVARWNVCLHKIKLPDSVLSIVHVESRVIVALANGTLAVFRRQVSGEWDLNSYHLLTLGSPKYSVRCLTIVGDKVWAAHRNKIHVIDPITLCILKSFEAHPRKESQIRQMATTGLGVWVSIRLDSTLRLFSAETYDHLEDIDIDPYVSKMLGTGKLGFSFVRITALLVSCNRLWIGTGNGVVISVPLTDASGASNTPYSPRFANAQLSFHGHRDAVKFFVSVPMNPPNQGLPTTSKDMLVISGGEGYIDFRLGDGDMEASVELEPNQTIENRNEKSYIIVWKVSNR
The following text describes a protein:
Function:
Involved in the activation and reutilization of phytol from chlorophyll degradation in plant metabolism, including tocopherol biosynthesis. Catalyzes the conversion of phytol to phytol monophosphate (PMP) (By similarity).
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MAAAAAWTGAASPNSLLLSRSPPHAAALAPSPGSSMRRRLLLGVGTPAVAALAAAAPPAVLQDGAVTVLITAGAYSLVRVFDELTERRLIEKSLSRKVVHVLSGVLFMSSWPLFSNSTEARYFAAVVPFLNSMRLLIYGLRLYTDEALELLRGPLYYVLVLLFSVLVFWRESPIGIVSLSMMSGGDGFADIVGRRYGSAKLPFNRKKSWAGSISMFISGFLLSAMMMLYFSSLGYIDVIWEEALGKLALVALAATVVECVPVTEVVDDNISVPLATMLVAFLLFSSNRTIVN
The following text describes a protein:
Function:
Transcriptional activator. Binds the cAMP response element (CRE). Activates transcription through box-B element and CRE. Seems to function synergistically with atf6 (By similarity). Regulates FGF21 transcription (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein; [Processed cyclic AMP-responsive element-binding protein 3-like protein 3-B]: Nucleus.
Sequence:
MDHYSDQGGDGIELLDLLFDKNDGILRYENMGQQNNQLWPVQDPHMMMTPQGNEDFFNALIGGSDSVSGSPVWSPSPSDSGISEDPHSDHIDSPPPNASPPMEPHIVVSQTQHSLNINFPFDFNGWETGFLPDQSGGTQCASETPQAQQTTGFPLTVKDLLLSGTPEPAAKVSQQSYQELILTEDEKRLLAKEGMTLPNQFPLTKYEERILKKIRRKIRNKQSAQESRKKKKEYIDGLESRMAACSAHNHELQRKVFQLEKCNISLMEQLRRLQALVMNGSNKPVQAGTCVLVLLLSFTLILLPNLKPFTDTKVSQHGDFSPMRVQSRSLHNLQSSRVLRNLDHPYSMTENAKILPRFPEDKTMEEIASLLGRLHRRPQFTEYDPESHNHSFDQHDEHHHGDPITGHVATVTLNPRRGSRRSPHADDM
The following text describes a protein:
Function:
Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids. Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)).
Subcellular Localization:
Peroxisome.
Sequence:
MNQDLRREREAASFNPELLTHVLDGSPENTRRRREIENLILNDPDFQHEDLNFLTRSQRYEVAVRKSANMVKKMRDFGIADPEEIMWFKNFVHRGRPEPLDLHLGMFLPTLLHQATAEQQERFFMPAWNLEIIGTYAQTEMGHGTHLRGLETTATYDPETQEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITKGKCYGLHAFIVPIREIGTHKPLPGITVGDIGPKFGYDEMDNGYLKMDNYRIPRENMLMKYAQVKPDGTYVKPVSNKLTYGTMVFVRSFLVGEAARSLSKACTIAIRYSAVRHQSEIKPGEPEPQILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEDIGHGDLSELPELHALTAGLKAFTSWTTNAAIEACRMACGGHGYSHCSGLPNIYVTFTPTCTFEGENTVMMLQTARFLMKSYDQVHSGKLVCGMVSYLNDLPTQRIQPQQVAVWPTVVDIDSPDSLTEAYKLRAARLVEIAAKNLQNEVIRRESKEVAWNLTSVDLVRASEAHCHYVVVKLFSEKLLKIQDKSIHTVLRNLCLLYCLYGISQKAGDFLQGSIMTESQITQVNQRIKELLTAVRPDAVALVDAFDFKDVTLGSVLGRYDGNVYEHLFEWAKKSPLNKAEVQKNCVFPPFEILHLNIKAERISELTPLRKLWNLLWLFQTLYLSNRFRRELGCSHSTQVFHFLNHLITVGHVHTYTKLEYCNTPLSHTST
The following text describes a protein:
Function:
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MSFHFALVWTLLVGPWMPMGSQNSISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLGEPHLPNPRALSNTAMRGPAGLASLQNRTVLGVFFGYHVLSDLVSVEKSGCPAEFLNIHIPPGDPVFDRDHSGDVVLPFQRSRWDPETGQSPSNPRDLTNEVTGWLDGSAIYGSSHSWSDELRSFSGGQLASGPDPAFPRAAQAPLLMWMPPDPTTGRRGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQKLARRYPLWGDEELFQHARKRVIATYQNIAMYEWLPSFLRKMPPEYAGYRPFLDPSISPEFLAASEQFFSTMVPPGVYMRNASCHFQGVINRNSSVSRALRVCNSYWSREHPNLQRAEDVDALLLGMASQIAEREDHVVVEDVRDFWPGPLKFSRTDHLASCLLRGRDLGLPSYTKARATLGLPPVTRWQDINPALSRSDGTVLEATAALYNQDLSRLELLPGGLLESHGDPGPLFSTIILDQFVRLRDGDRYWFENSKNGLFSEREIAEIRNTSLRDVLVAVTKVDSGALQPSVFFWHAGDPCPQPGQLSTKGLPACAPPIMRDYFEGSGFGFGVTIGTLCCFPLVSLLSAWIVAQLRRRNLKRLQGQDRQSIMCEKLMGGIKAMEWQGRKEPCRPVLVHLQPGQIHMVDGRLSVLRTVQLRPPQQVNLILSSNHGRRALLLKIPKEYDLVLLFDLEEERQVMVESLRGALKESGLNFQEWELREQELMRAAVTREQRSHLLETFFRHLFSQVLDIDQADAGALPLDSSQKVQEALTCELSRAEFAESLGLKPQDMFVQSMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLTKTQLAEVVESMFRESGFQDKQELTWEDFHFMLRDHDSELRFTQLCVKGVEVPEVIKDLCRRASYISQEKLCPSPRVSAHRPRKDADIEVELTPRRLQYPNDTDPPQEIRRRFGKKVTSYQPLLFTEAHREKFQRSRRHQTVQQFKRFVENYRRHIGCLAVFYAIAGGLFLERAYHYAFAAHHKGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRLIASTAIVLTVLHSAGHVVNVYLFSISPLSVLSCLFPGLFHDNGSEFPQKYYWWFFQTVPGLTGVMLLLILAIMYIFASRHFRRCSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFHIFFLVPALIYVGDKLVSLSRKKVEISVVKAELLPSGVTHLEFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEETLSLHIRAAGPWTTRLREIYSPPTDDSCAKYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDRQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSVTHFGRPPFEAFFNSLQKVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of KRP1 and KRP2.
Miscellaneous:
MISCELLANEOUS: Favors geminivirus replication by up-regulating the host cell cycle.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAEDSLRVGMISSGLAVLLNGEDAKENSSKARIVPHFDYSGHRPLERTIEFIFGLAEKSVGPLDGQVDSSLIRAVIKNQFSKLHGDLDVSVSQREGISVVHHGVGPPIVGLEEFSICGDIRIVKPPLVLESLALFSSARANACIWKGKWMYEVALETSGIQQLGWATLACPFTDQKGVGDADDSYAFDGRRVSKWNKEAEPYGQSWVAGDVIGCCIDLNCDEIYFYRNGVSLGAAFTGIRKLGPGFGYYPAISLSQGERCELNFGAYPFKYPVDGFQPLQEAPTRFSFATELLRCFSRLLDRPDRSLADTLSRLRRFASVEELFCPVSSAICDEFFYILEQDPLLAEYLGRGAFLSFLLETFRTQAPHDSSSLDKVLDVFLEFPQSHLIFEHVVNALACGCKTATLILTECPYSGPYPYLALACHLFKREELMVQWWRSLHFEFLFEGFLSCRSSNKHDLQHLMPVVWWPGSSEDISYESSMGFTISALSEAINKIEEKQRNLCLLVIQFIPPVSPPQLPGSAFRGFLQNLLLKNRGADRTLAPSGVTRNSVLVSLFSVILHFLSEGFAMLKSSEAVHHNVGFLHRGGQQKFPLSLFLKNDPHRADITRLGGLFSHISKSYPTDDQEEEIMRWEEGCMDDEQNRVTHATEQKPCCCLAYDTDLTKSLKDRGKNTAQSSRGRCSSIPERSSHVAAECSAGSFSEEIDDKPSTSNQSDPDFGYRPVRFMRTALQESRISSAILSEEELLDALLLLYHIAVAPNFKQASYYMSHQSQSISLLEETDKQIRERASCDQIKRLKEARNNYKEDVMDCVRHSAWFRISLFSRWKQRGMYALCMWVVQLLLVLSKMDSVFVYIPEFYLESLVDCFHVLRKSDPPFVPSTTFIKQGLSSFITFVVTHFNDSRISNTDLKDLLLQSISVLVQYKEYLEAFENNEAATRHMPAALLAAFDNRSWIPVTNIFLRLCKGSGFSSLKNGESSFSSTVFQALLRDACINDGELLSTFLNRLFNTLSWTITEFSVSVREMQEKYQVMEFQQRKCCVIFELSSNLARVLEFCTYAMPQAFLAGTDTNLRRLTELILFILNHMTSAVDDEFFDLSLRRQGQPSEKVSRGILLAPLVGIILNLLEASEDSKPKQQHDVIGLFASMDCPDTVYYGFQYLLEYNWDGCVSGDDAYVKKLGQLENFLSHLINRASSQEPERKEESFNKDTTDIEDNTCCICYAGEANAMIAPCSHRSCYGCITRHLLNCQRCFFCNATVIDVIRDKEEEEEEDDDGHKRST
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
MLSHFFKIFKKIVLSFLSFFGCFLEIAMGKIIVENLTSPSHPTLKYNEIEKKNINLSSVKIEVEEEEQKEMDLSFYDGSPDWIRSTPTMITGADSDSIDYKISSDSSGYSYSDGDEWSPLKGEPSSLIGPICSTDPDNFKKIVQKETKPIEYKNFKIKGIGMCNLGNTCFVNAVVQSFIHNVVFLQLLRSIDHASPCQNFSCYFNFNQQQDAHEFLQCFLNQLETCCYYLETKDNVVKEAFGGRFMSKLRCCNCGHSSITREPLIDISLEIEGIDSVPAAFESFTKIEKIEFYCKRCKTYGPFEKQLLVDQAPTVAALHLKRFKNNGLVSQKVENHVSFPLELDILLYTNNINNIKYDLYAVIVHSGPSISSGHYYIFIRCAPNEWYKFNDEKVDYVQEDLVLAENAYILLYTKKGTLWFADYVEIHRPFVDLIMATTSNDFSYETSLKPALNEIEDNGSHVQVYGEDQFQNVETKKDNELMDALKCN
The following text describes a protein:
Function:
Participates in checkpoint pathways arrest of the cell cycle. A mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.
Subcellular Localization:
Nucleus.
Sequence:
MRRQLSFHESTKRSLKKKKIRKIEKPSLVSKTSRDKNASITDIHEEDIEAFSDEENKIVHLNNLKEDRFQLWFEKYIPQKAADLAVHKSKISAIKQWMLTDSLESRLLLICGPSGCGKSTAVQVLAKELGYSLIEWLNPMNLKEPSNQESDTLSLTEKFSRFMSLCETYPELELMDSNNIQKRGKNAQGKKKFIFLDEIPHLSKFNGSLDAFRNVIRTALTSRGAFSIIMVLTEIQLNNLEGINSQDRNSFNSVQIMGNDLLQDPRVTVLQFNPIAPTYMKKCLGSILRKEGVPKSPKLLSLVENICSASEGDLRSAINSLQLSISQSFEKKGTKNIREVKEGKGKGNDFSLEAAQVLERLSKSDSEAYARFKNYKSAYIPKSDKNENSFFKKDVGLGMMHAIGKVVWNKREGDDEVLKASSQQTGNSERIKGVKVSKSQENKNCISLKSDQRERMLNVDQCFTSKRRSLVDIESTINQSGLSGSVFRYGLFENYVDSCVTTDEAFNVCDLLSISDCLSHDFPYSYTGDEISTWFSVQGTLFYLPSPVPRKWRQLRFQQWNNEGIVRGIFDDYMVIYGKRSVSDPVIEAHEDQVLEDIDDPIEDED
The following text describes a protein:
Function:
Not essential for epidermal patterning and not redundant with STRUBBELIG.
Miscellaneous:
MISCELLANEOUS: Over-expression of SRF3 led to male-sterility in both cv. Landsberg and cv. Columbia.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MAAKRSIYCLLLLPLLLSLLIWIPSISLAATNPDDVAAINGLFAALGAPVLPGWIASGGDPCGEAWQGIICNVSDIISITVNAANLQGELGDNLAKFTSIRGIDFSNNRIGGSIPSTLPVTLQHFFLSANQFTGSIPESLGTLSFLNDMSLNDNLLSGELPDVFQNLVGLINLDISSNNISGTLPPSMENLLTLTTLRVQNNQLSGTLDVLQGLPLQDLNIENNLFSGPIPDKLLSIPKFLHEGNPFNATMINSTSTAPSLSPSLSPTKPAPTRPFSGVPPPPNERNRGKVADGPSDSEGSSSENSKGKNSSHTKKIILIAFAGVLVFIILVLAILLLLPKCARRREHANRVFKPHQVGADRGSRENALENGTPVLPPPGRSEKVQREPFKKAGEEPKVLHDLERLRRPAPISRQESQDIDFSMLMPPPPPPPPPPPPPPLDEKVTVMPIISPERPVKKTSPKRLPLTSVKHYSIASLQQYTESFAQENLIGSGMLGSVYRARLPNGKLFAVKKLDKRASEQQQDHEFIELVNNIDMIRHSNIVELVGYCAEHDQRLLVYEYCSNGTLQDGLHSDDEFKKKLSWNTRVSMALGAARALEYLHEVCEPPIIHRNFKSANVLLDDDLSVLVSDCGLAPLISSGSVSQLSGQLLAAYGYGAPEFDSGIYTWQSDVYSFGVVMLELLTGRMSYDRDRSRGEQFLVRWAIPQLHDIDALGKMVDPSLNGQYPAKSLSHFADIISRCVQSEPEFRPLMSEVVQDLLDMIRRERHGSGDSTAD
The following text describes a protein:
Function:
A bidirectional acetate kinase that may drive flux through the ethanolamine (EA) degradation pathway under anoxic conditions found when this bacteria infects the host intestine. It may generate ATP that can be used by other enzymes (EutA and EutT) in the eut pathway. Can use GTP instead of ATP with reduced efficiency. Might be required to correctly target EutE to bacterial microcompartments (BMC) (Probable). Required for the biogenesis of multiple mobile BMCs per cell. Might serve as an assembly hub for BMC shell proteins. Expression of eutK, eutL, eutM, eutN, eutS (eutSMNLK) in E.coli leads to formation of a single BMC; coexpression of eutQ with eutSMNLK permits E.coli to make cells with more than one mobile BMC, as is usual in vivo. EutS alone also forms BMCs, but in the presence of eutQ both BMCs and protein filaments are formed; Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon. EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection.
Subcellular Localization:
Bacterial microcompartment. Note=May be found on the cytoplasmic face of the BMC.
Sequence:
MKKLITANDIRAAHARGEQAMSVVLRASIITPEAREVAELLGFTITECDESVPASTSAQACKSESQRIREAIIAQLPEGQFTESLVAQLMEKVLKEKQSLELGTMQPSFTSVTGKGGVKVIDGSSVKFGRFDGAEPHCVGLTDLVTEQDGSSMAAGFMQWDNAFFPWTLNYDEIDMVLEGELHVRHEGETMIAKAGDVMFIPKGSSIEFGTPTSVRFLYVAWPANWQSV
The following text describes a protein:
Function:
Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors. Functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion.
Subcellular Localization:
Cytoplasm. Lipid droplet.
Sequence:
MTTTEPVQEPNLSTSSEKNGDMTRGSGNERRICQGRCSTRRNDVDEEGFLYRWMPRWSPTSAKLLEKAEEKILECLTVPYESFFVEIDDGENKIRTIKMNPSNSTKTPYVLVHGFASGVALWVMNLEELSADRPLYAIDVMGFGRSSRPKFPFGPEAAEAEFVRSIEEWRKALGLEQIIPVGHSLGGFLSSAYSLAHPEQVKHLVLLDPWGVVKKDEEKTIEMPYWARIIGTIVLSFNPLSTIRAAGPLGPYLIKKARGETVGRKFSSLFNDDRVTQYIYHCNAQYPAGEQAFKDISMQVGWARNALEDRIGELPADIPISMIYGSRSWMDFTGGNLVKQLRRNSRVDVRIIKGADHHVYADKSGQLNTLINTLCKDST
The following text describes a protein:
Function:
May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles.
Subcellular Localization:
Nucleus.
Sequence:
MSCLDVMYQVYGPPQPYFAAAYTPYHQKLAYYSKMQEAQECASPGSSASGSSSFSNPTPASVKEEEGSPEKERPPEAEYINSRCVLFTYFQGDISSVVDEHFSRALSHPSSYTPSCTSSKAHRSSGPWRAEGTFPMSQRSFPASFWNSAYQAPVPAPLGSPLAAAHSELPFATDPYSPATLHGHLHQGAADWHHAHPHHAHPHHPYALGGALGAQASAYPRPAVHEVYAPHFDPRYGPLLMPAATGRPGRLAPASAPAPGSPPCELAAKGEPAGSAWAAPGGPFVSPTGDVAQSLGLSVDSGKRRRECSLPSAPPALYPTLG
The following text describes a protein:
Function:
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Golgi apparatus.
Sequence:
MSQGILSPPAGLLSDEEVVVSPMFESTAADLGSVVRKDLLSDCSVISASLEDKQQAPSEDSTEKVKVYLRVRPLLPSELERQEDQGCVHIENVETLVLQAPKDSFAQKSNERGIGQATHRFTFSQIFGPEVGQASFFNLTVKEMVKDVLKGQNWLIYAYGVTNSGKTHTIQGTIKDGGILPRSLALIFNSLQGQLHPTPDLKPLLSNEVIWLDSKQIRQEETKKLALLNGGLQEEELSTSLKKSVYIESRMGTSTSFDSGIAGLSSTSQFTSSSQLDETNHRWAQPDTAPVSVPADIRFSIWISFFEIYNELLYDLLEPPSQQRKRQTLRLCEDQNGNPYVKDLNWIHVQDAEEAWKLLKVGRKNQSFASTHLNQNSSRSHSIFSIRILHLQGEGDMVPKISELSLCDLAGSERCKDQKSGERLKEAGNINTSLHTLGRCIAALRQNQQNRSKQNLVPFRDSKLTRVFQGFFTGRGRSCMIVNVNPCASTYDETLHVAKFSAIASQLVHAPPVQLGFPLLHSFIKEHSLQASPSLQTGAKTDPGLDDDIENEVDISMYGKEELLQVVEAMKALLLKERQEKLQLEMQLRDEICNEMVEQMQQREQWCSEHLDTQKELLEEMYEEKLKILKESLTSFYQEELQERDEKIEELEALLQEAKQQSMAHQQSGSELSLRRSQRLAASTSTQQVQEVKAKLEQCRAELNSTNEELRKYQKMLEPPPSAKPFTTDVDKKLEEGQKNIRLLRTELQKLGESLQSAERACCHSTGAGKLRQALTSCDDILIKQTLAELQNNMMLVKLDLRKKAACIAEQYHTVLKLQGQASSTKKRLGANQENQQPNQQPPGKKPFLRNLLPRTPTCQNSTDCSPYARILRSRRSPLLKSGPFGKKY
The following text describes a protein:
Function:
Alternative NADH-ubiquinone oxidoreductase which catalyzes the oxidation of mitochondrial NADH does not translocate protons across the inner mitochondrial membrane.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Peroxisome.
Sequence:
MRPFAYFERLSQAFHDYPSLSKILVVSTISGGGLIVYSEANPSYSNNGVETKTRKRKVVLLGTGWAGASFLKTLNNSSYEVQVISPRNYFAFTPLLPSVTCGTVEARSVVEPIRNIARKQNVEMSFLEAECFKIDPGSKKVYCRSKQGVNSKGKKEFDVDYDYLVIATGAQSNTFNIPGVEENCHFLKEVEDAQRIRSTVIDSFEKASLPGLNEQERKRMLHFVVVGGGPTGVEFASELHDFVNEDLVKLYPKAKNLVQITLLEAADHILTMFDKRITEFAEEKFTRDGIDVKLGSMVVKVNDKEISAKTKAGEVSTIPYGMIVWSTGIGTRPVIKDFMKQIGQGNRRALATDEWLRVEGCDNIYALGDCATINQRKVMEDIAAIFKKADKENSGTLTMKEFHEVMSDICDRYPQVELYLKSKGMHGITDLLKQAQAENGSNKSVELDIEELKSALCQVDSQVKLLPATGQVAAQQGTYLAKCFDRMEVCEKNPEGPIRIRGEGRHRFRPFRYRHLGQFAPLGGEQTAAQLPGDWVSIGHSSQWLWYSVYASKQVSWRTRVLVVSDWMRRFIFGRDSSRI
The following text describes a protein:
Function:
Magnesium-dependent glutamate N-prenyltransferase: part of the gene cluster that mediates the biosynthesis of domoic acid (DA) and derivatives, natural products with neurochemical activity acting as ionotropic glutamate receptor (iGluR) agonists, thus being neurotoxins causing amnesic shellfish poisoning (ASP). Catalyzes the conversion of L-glutamic acid (L-Glu) to N-geranyl-L-glutamic acid (NGG) in the presence of geranyl diphosphate (GPP). Also able to catalyze the formation of farnesyl-L-glutamate from farnesyl diphosphate (FPP). Cannot use dimethylallyl diphosphate (DMAPP) as substrate.
Sequence:
MKFATSIVAAIATTGAAFTVIPQKLSHPSQLNALNTMGSISSITAESPKEVLSRVQDAGLTLTNPNDLYWMVDFLKEKYYDNGDYYYPIKTVCDGESIDVKFYCPFEPSLSPHYLELYGSRDERASIYETTMKKYNRINSEKTSAICTPYSSYGDTQIVAYFYSMMYYINDQTAHLKLPESEIESELIDILNDDILIYLNEFMSIFEPEDAQDLERIWDFLDFYQPYFSKVDGKIVLDEKYLVRTPSQMPLIKTICEYVSEQFAPSKNITQVIWEVVRYIKGVKDEIHIRGDKSFTLSLQEYDDFRDKVTASPMAHAVSDLTHERFSYEAYTNPAFMELENRCSEIITYFNDVCTSDRERLDEDPFNSVFILMDLDPSLNFAKSCDVVVEHAYNKMQAFLKLKEEILESASDEEERLALARMIKTREDSLIGYVLHEVCCVEDGYARDHKPLMKAFLEEEITKSLAEKVKFNPVESESVRLN
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MWVHRAKPLLQLQTISRCLRSPCYIFSLLSYSDVPHKKTPLQETRMRDRFTLYAKGGDGGNGSTSFRRSRHDRRGEADGGNGGRGGDVILECSTAVWDFSGLQNHVNAGRGGHGTSKNKIGTRGEDKVLQVPIGTVIHLKKGEIPSMVEHRSSTDLDPWELPGTLANDQSEVDQQTASKNSSMAEKVKSVHVAGQLSSCTEITVEQYSLKNGLTVDQSRGMKQANGPESEALEEIRYNVAELTEQGQRMIVAHGGKGGLGNVCYSSGPMKPKTSKDEVHRDKAFEVEVSNDDRSSLRTGLPGSEAVLVLELKSIADVGLVGMPNAGKSTLLGAISRAKPAIGHYAFTTLRPNLGNLNFDDFSITVADIPGLIKGAHQNRGLGHAFLRHIERTKVLAYVVDLAAALDGRKGIPPWNQLRDLVLELEHHQEGLSNRPSLVVANKIDEAGAEEVYEELERRVQGVPIYCVCAVLEEGISELKAGLRMLVNGDEKSNSLSVENIKCSRNLNLESAEKTTTETIISGVATVKTNFEGTEVSSEGGNGCKCGSNCSCDPCNC
The following text describes a protein:
Function:
Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MFAIGFWAIVGAAVGSCINVVAHRLPQGISLWWPPSRCPGCLTPLGPLENVPVLGWLWLGGKCRHCRMAIPVRYALVELGTAGLSGVLAWHFQAAFTSTSLVEVACWGFFVAVLLALSLIDLDTLELPGELTAAGIVGGLVFRTFFPVWASGAWASGPPGLVDALYGLLVGIGLFDVISYVGEKAMGKEAMGGGDATLAGLIGVWLGWKLLLVSLAFGFGLGAVFGLAGIAAGRLKREEPLPFGPFLALGALGGLLFGESWITSYMTLF
The following text describes a protein:
Function:
Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFANADTPPQVVVLGAGAWGSSLAYVLNNNDIPTQVWSRRSPQSLESMVAGADVIVSAVSIKGVPSVAARLEAMDLQRRTILVTATKGLDPETMTTPSQIWQAALPSQPIAVLSGPNLSKEIDQGLPAATVVASSDQAAAEEIQTIFAADNFRVYTNNDPLGTELGGTLKNVMAIAVGVCEGLGLGTNAKSALITRALPEITRVGLHFGAQPDTFWGLAGLGDLLATCSSMLSRNYRVGYGLSKGQSLEEILANLGGTAEGVNTTDVLIKIANREKIAVPITRQVYRLLHGKITPPQAVEALMERELKAEFEDFDL
The following text describes a protein:
Function:
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine.
Sequence:
MTKTIKLLTYNVFIRPPGIKNNENDWKDERIECLISDSLSPHINYNKGSKSAQGIPNAVYSVDKTSFPYIPYFSPWKYPVYGKLMEVTGMNKKAKSPPPPSSLKQQNLHNNSSDYQSIAPSKSILAQYDIICLQELFSAFSYRQRRFIEKAEQQGFQYYATSPSPPYLRSTFLVDGGLTVISKYPIVASDFFLYEQGVDSDMLSSKGVLYTKIKVVPTGSSNDDENFIHLFTTHMQASYAPKSDGSKTVKASATQDQASNYKNDNIRLIQLNQLREFIFEKTFKDKSIIILAGDLNVNGRVSKDDPKDGDSYLQMLELLSNSDQRDLPTGKKIFTIQDLLRDDFNGEHPPTVGDIKFLKDKKQEIPLETVLTNPNDFGCMKRLDYILLFNREFETSIDGVELNFKVPSPTQPSKHSQQHNSISPLKGSTKVDPFFIQGFPFTQLSDHYGVSTILQINK
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular Localization:
Nucleus.
Sequence:
MDYMNLGITSRKTGLRVKQSIRRDEHSMENVDDFFAEDDESTVSSRRQSRRTSLLSDLKPHLSGAGAAHLFLDEDGFRIPSSAPQPRKQAAWSQRRQTETELDEYPPLDPGLPPIEDAFEEEPVAAGKYTGNGTPPYGTKYATRYDIPREEDSDVEESTIRLTPTKPTDDDYRDVPGLVDDNETTRDNTSFNTSEHALLEDEMEDDYEVDSADEEDGEYVDAVSRAEDSSASEHDDSDDSSASDADDAGLSRQNQRSKNGYMGDSDSEVLDSDEEYIQQQAKQLLPSGLDGGRSTGIRRSKRVRVPPLDYWRNEKVVYKRKSDKPVLEIDKIITYDQEEEEDEEEVRPKKKNPKTKARPYNYIPTGRPRGRPRKNAPQPATNNNEPNRDLLLKLENGEISNGEWLKHGILKGTVNISADKKGNEIVAFAPGLSQSEQVQESEDEKFTLAVMFDKYREMFASGMLILPVDGMKSVSDSYNAFITFYVVQGIVEVTLSENKFICTEGSSFQVPAFNTYAFQNAGHNEAKLFFVQVTVPENFDGSNGAAVDLQETSSRRTTGHSLSSSDMSLTTP
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MALYLIVRTNVMQLLLARGWSVEAPAPPDVNELDPDLLSQFQRESQLMVELSPVLSKSQILQPDEHHAEPLHKCWIEPVESAACYHALGAKLTTIAQAIGRALYRLYFIRHNEQTGATRETLQVYSEYLKDFNNTSMSRNALADTWRRVEQRLGIKTDDQYDSDLLSPWPIPVLLACGTSLLEVVLQTSSTGHLPNHDKKPVAAFYHMMQLDGVKRVGYIRCHKLVLDRVSGQASDRGSCVPSKVAIDASQLPMTIPPRPWTSVRKGAYLICPSAIMRTGDWAFQHFALLSEATHNLARVFNAISALSATAWKVNGQVLRVVTELFHSEDGYDDLGIAPFRVNYEVDKTDPKSLKTHKKLSNEAHSLRSDLHLRLMVAHWLGEKQFWLPHNLDFRGRAYSMPPYLTHIGNDMARGLLTFAETKPLGADGWRWLKVHLANVYGKDKLPMDERAKFAEDNMENVLSSADRPLAGLLEPGEKSWWLKGENPWQVLATCMELAAAYRSGNPEAYESGFPVHQDGTCNGLQHYAAMGGDIAGARHVNVIPTPEDDRPQDVYSAVAAKVDELLHMQATTGNFEHFPREVKDPERYKQLARLLMEQGPMKRKIVKQTVMTNVYGVTYIGGRDQILRQLKAHDYVPDALMKDCASYLTLLIFVNAQKIQKWLSRQARMIASSGEPVSWVTPLGLPIIQPYHMAAKRQITTSLQSVMTTVTTSPIKPPNVVKQSSAFPPNFVHSLDSTHMLQTAAACTKDGLTFAAIHDSYWTHAASVDVMNLHTRQQFLLLHEAPLLDNLLRFFRAQHEGRPLREQYQKRYGQTNVVFEPCPSKGDLDLHRMKTEIDYSWWRCASGPTTATGDPQVALNKIFHHIANNTVPKSIRHALCSINYTILEKANGKFRPVRTDSIFTRANTGGFGLHDLVERGPVAYVCNMAKLATRYPRVYDRLLEDASRAAYFEDHVQRAGFQMATVKDAATQRPAEIIALRSKAVLDDLMAKCALDLQQAYLASREWGVSTVLTMRGRDKLRRLSDTTFAIAVVSMMGFGLHELINVKPTDKCPLCSSKTPQPRLTREHLLTCRPIKRHNALRDEMGRLLRYATLSHVWVEKSGYNANGQSCRIDLHCRNPFPGGALGPALPDLGIDVTVRTAQPPTTSQACIKVGAALRRAEKEKRDYYTGFNHGKTLIVPAAMTTTGGFASSFVDLLGQLARCAEARGVYQPGLDEAFVPRWKGRFAALVHQMNADHIQRHFGGVCLRSS
The following text describes a protein:
Function:
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Subcellular Localization:
Nucleus.
Sequence:
MSDAAVDTSSEITTEDLKEKKEVVEEAENGRDAPADEENGEQEADNEVDEEQEEGGEEEGDGEEEDGDEDEGAESATDKRAAEDDEDNDVDTKKQKTDEDD