lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
Miscellaneous:
MISCELLANEOUS: [Isoform 5]: Expressed at very low levels in most tissues.
Subcellular Localization:
Mitochondrion. Golgi apparatus. Cell membrane. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II; [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.
Sequence:
MTDDNSDDKIEDELQTFFTSDKDGNTHAYNPKSPPTQNSSASSVNWNSANPDDMVVDYETDPAVVTGENISLSLQGVEVFGHEKSSSDFISKQVLDMHKDSICQCPALVGTEKPKYLQHSCHSLEAVEGQSVEPSLPFVWKPNDNLNCAGYCDALELNQTFDMTVDKVNCTFISHHAIGKSQSFHTAGSLPPTGRRSGSTSSLSYSTWTSSHSDKTHARETTYDRESFENPQVTPSEAQDMTYTAFSDVVMQSEVFVSDIGNQCACSSGKVTSEYTDGSQQRLVGEKETQALTPVSDGMEVPNDSALQEFFCLSHDESNSEPHSQSSYRHKEMGQNLRETVSYCLIDDECPLMVPAFDKSEAQVLNPEHKVTETEDTQMVSKGKDLGTQNHTSELILSSPPGQKVGSSFGLTWDANDMVISTDKTMCMSTPVLEPTKVTFSVSPIEATEKCKKVEKGNRGLKNIPDSKEAPVNLCKPSLGKSTIKTNTPIGCKVRKTEIISYPRPNFKNVKAKVMSRAVLQPKDAALSKVTPRPQQTSASSPSSVNSRQQTVLSRTPRSDLNADKKAEILINKTHKQQFNKLITSQAVHVTTHSKNASHRVPRTTSAVKSNQEDVDKASSSNSACETGSVSALFQKIKGILPVKMESAECLEMTYVPNIDRISPEKKGEKENGTSMEKQELKQEIMNETFEYGSLFLGSASKTTTTSGRNISKPDSCGLRQIAAPKAKVGPPVSCLRRNSDNRNPSADRAVSPQRIRRVSSSGKPTSLKTAQSSWVNLPRPLPKSKASLKSPALRRTGSTPSIASTHSELSTYSNNSGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Subcellular Localization:
Cytoplasm.
Sequence:
MRIFLVGMMGSGKSTIGKRISEVLDLQFIDMDEEIERREGRSVRRIFEEDGEEYFRLKEKELLKELVERDNVVVATGGGVVVDPENRELLKKEKTLFLYAPPEVLMERVTTENRPLLSEGKERIREIWEKRKQFYAEFRRIDTSRLNEWETTALVVLEALDEKEISTIEKPHLVKIILGGFKRVRNEELVFTTERVEKIYGRYLPENRLLFPDGEEVKTLEHVSRAYYELIRMDFPRGKTIAGVGGGALTDFTGFVASTFKRGVGLSFYPTTLLAQVDASVGGKNAIDFAGVKNVVGTFRMPDYVIIDPTVTLSMDEGRFEEGVVEAFKMTILSGRGVELFDEPEKIEKRNLRVLSEMVKISVEEKARIVMEDPYDMGLRHALNLGHTLGHVYEMLEGVPHGIAVAWGIEKETMYLYRKGIVPKETMRWIVEKVKQIVPIPVPSVDVEKARNLILNDKKILKGSRVRLPYVKEIGKIEFLEVDPLELLEVVD
The following text describes a protein:
Function:
Member of a two-component regulatory system QseB/QseC.
Subcellular Localization:
Cytoplasm.
Sequence:
MRILLIEDDNLIGNGLQIGLTKLGFAVDWFTDGKTGMAALTSAPYDAVVLDLTLPKLDGLEVLQQWRSNHQDVPVLILTARDTLDERVKGLQSGADDYLCKPFALAEVAARLQALIRRRYGYHHSVIEQAGVKLDQNQRSVWLNNQPISLTSREYKLLELFMLNKDRVLSRSSIEEKLSSWDEEISSGALDVHIYNLRQKLGKQFIRTVHGVGYALGQVEK
The following text describes a protein:
Function:
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
Sequence:
MTLFVALIDEITISGSVGLSVHGLYRVITERTIFAMPKTSIGLYPNVEGSYFLLRLKGRLGIYLGLTENRLKGKDVYFAAIATHYIRSQDICELEEKFISQDNITDRINREILNQYHMKNDGDQRFYEGAKAVLIDRDHNPKWDPATLEEVTDENINAQFKPSDDGDLILPRQQFL
The following text describes a protein:
Function:
Cilium-specific protein required for cilia structures.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MEDDQINNSEVQKPLVDEVIYPDIEPGIINRSLIESSYLKHVHRGEGRRLHQLEPVVLEQILTMRLEFNNILRIDHLWILPNLTKLCLNCNKIETIENIEMLTNLKDLNLSFNFIEKIENLDTLVNLEVLSLFSNKIEAIENIDMLTMLVIISLGNNLIDTVEGIERFRFMNNLKIINLEGNPIAKRTNFCLLKYISAILPKLNYYEYTFIKSELRAEACNLYYREIREIEDKQEKEIQARKFLEREQSEAKRLASSFVEHLDGHQLFDSLWRGDEDGRVLMLVGTQAQELADEYDKDIFELTQEIYKLGLERFTERDEEIRDFFNNLFDGQEELQILGQNEIEWFLQFREIIFEEARIRLLKLEQNSMHGEDEDTPENLKLSDALDKLNIQFEDAINDLWQALMAQELYLHESIQESTINFHRKIAELMSKFVEQSQAFFVQLREITLHFSENMTEILTRFISTKFALQDFDDVPIELRVCVDDRDAILNLIAGMKDYHTLRLDEREDTIATRTKEFVDNMIDQLNSNEVERHRSKILEINFFVEMMTDAMTSLPHDVRDELIAEDYV
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Sequence:
MASDATILLQEISHGQQNPVVDQPQSFVASNDPQPHLLGPPGSFLPGQADQHWRTNPFHEDCPPGLEQLIEADEVVVQNTNEVLKKVSCLENNNKYVVKNSVDHKIFSTVEDSGCCSRFWCCSNTRSLELKIINNFGNEVIHLNRPLACACYLCACCLYPCCLQKMKVSAPPGNVIGTIEQEWSIFPRFKVKDVSGNVVLKIKVRAERVTAELKKLEVFRKKRARLSKGIDNFGITFPMELDAKMKAVLLSACFLIDFLYFESDREHGSVGDDGYEANDSISNDNSA
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Sequence:
MALNEGQLTAEAIRLAQLAKQDVGGATTAQLGLLGSHPADNAAIPVAADSEAVDANRPASPAVSAPNCAMCGQPDKYRCPKCERKTCSLACVKAHKAQYECDGIRPRSRMTREKSELTDQVLWRDYCFLEDAARMVGAKTRPIGASVRQAAAEAPTAGTGDVYRNFGRLLKVASSHGIRLELLPDVYERHRANTSRAHDRMARIHWRVEVVFGSVKFTQPRVPCARPLRQILDAYLLQTSENAVERHKVEPYWRRRAEATVLVANLDTPATARQYVRLDEDMTLRDALRFLRVLEFPTLHVVLPEDMEAHVLCERPTSIPPPLNTRPPGFRGRARGRGRGRGQGRGRGGRGRGPSSHASRGRAARGRSSSE
The following text describes a protein:
Function:
Exports the biofilm adhesin polysaccharide poly-beta-1,6-N-acetyl-D-glucosamine (PGA) across the outer membrane. The PGA transported seems to be partially N-deacetylated since N-deacetylation of PGA by PgaB is needed for PGA export through the PgaA porin; Required for the synthesis of the beta-1,6-GlcNAc polysaccharide (PGA or poly-GlcNAc) that seems to serve as a biofilm adhesin.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Domain:
Contains a predicted C-terminal beta-barrel porin domain and a N-terminal periplasmic superhelical domain containing tetratricopeptide repeats, which may mediate protein-protein interactions, perhaps with PgaB.
Sequence:
MYSSSRKRCPKTKWALKLLTAAFLAASPAAKSAVNNAYDALIIEARKGNTQPALSWFALKSALSNNQIADWLQIALWAGQDKQVITVYNRYRHQQLPARGYAAVAVAYRNLQQWQNSLTLWQKALSLEPQNKDYQRGQILTLADAGHYDTALVKLKQLNSGAPDKANLLAEAYIYKLAGRHQDELRAMTESLPENASTQQYPTEYVQALRNNQLAAAIDDANLTPDIRADIHAELVRLSFMPTRSESERYAIADRALAQYAALEILWHDNPDRTAQYQRIQVDHLGALLTRDRYKDVISHYQRLKKTGQIIPPWGQYWVASAYLKDHQPKKAQSIMTELFYHKETIAPDLSDEELADLFYSHLESENYPGALTVTQHTINTSPPFLRLMGTPTSIPNDTWLQGHSFLSTVAKYSNDLPQAEMTARELAYNAPGNQGLRIDYASVLQARGWPRAAENELKKAEVIEPRNINLEVEQAWTALTLQEWQQAAVLTHDVVEREPQDPGVVRLKRAVDVHNLAELRIAGSTGIDAEGPDSGKHDVDLTTIVYSPPLKDNWRGFAGFGYADGQFSEGKGIVRDWLAGVEWRSRNIWLEAEYAERVFNHEHKPGARLSGWYDFNDNWRIGSQLERLSHRVPLRAMKNGVTGNSAQAYVRWYQNERRKYGVSWAFTDFSDSNQRHEVSLEGQERIWSSPYLIVDFLPSLYYEQNTEHDTPYYNPIKTFDIVPAFEASHLLWRSYENSWEQIFSAGVGASWQKHYGTDVVTQLGYGQRISWNDVIDAGATLRWEKRPYDGDREHNLYVEFDMTFRF
The following text describes a protein:
Function:
Involved in osmotic and salt stress tolerance. May play a role in the control of meristematic cell size during osmotic stress. May function as an adapter protein for BRL2 and may be required for signaling affecting leaf vascular tissue pattern formation.
Domain:
The thioredoxin domain is inactive.
Sequence:
MSHSRRLSLEPAIDSITGRFRDLQRNDDDVNKPDFRELDLGSPVSTLMPRGSASSSAAATPTSSSGSSGSASGKPSVSSQMAKRLDDAYKSHSGELSSPGSGMPTTTRILKPGHRRSSSTGTPLIFSGSSFTSATSHTSPQGGGSGATSAVSPNTGVLPAGNICPSGRILKTGMASRTSSRTETLCTGTGNYGHGNVVRSGGGGGTSGKAVRVAENGENPEELKRMGNDMYRRGSFSEALSLYDRAILISPGNAAYRSNRAAALTALRRLGEAVKECLEAVRIDPSYSRAHQRLASLYLRLGEAENARRHICFSGQCPDQADLQRLQTLEKHLRRCWEARKIGDWKTAIKETDAAIANGADSSPQLVACKAEAFLRLKQIEDSDFCVSCIPRLDHHYHSQPQVKLFGMVVEAYVLCIQAQVDMALGRFENAVVKAERAAMLDQTNPEVVSVLNNVKMVVRARTRGNELFSSGRFSEACVAYGDGLKQDDSNSVLYCNRAACWYKLGLWEKSVEDCNHALKSQPSYIKALLRRAASYGKLGRWEDAVKDYEFLRRELPGDSEVAESLERAKTVLMNRSQESKSLGFNNEVEAVSTLDKFKKSVALPGVSVFHFKSSSNRQCEEISPFINTLCLRYPLVHFFMVDVEESMALAKAESIRKVPTFKMYKNGDKVKEMVCPSHQFLEDSIKHFLL
The following text describes a protein:
Function:
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPRIEPLEPLKESSTIYDALAIKEEKEQPPPKPAKKPAKKKPKETEKQQAPRSLAYTLSQLEGDEIAQLMAEVELRFPSTPLLWLKDLAAFLNKRLEHTPESPNLAEHPTGFPLSGVSAGVRAQLRAAMSNKALHGLFWEHCLSNLLTDFAKGTSWVFQLVELRSKNQQKQPQCLLVLWAACQAGLSDLSKGLAVWMDLLLPVAGVRPYAALVVDYLSNLLERHPSKVAGLGDQGVRQLFTILDLAFGGSLPVSPKQQETLLALYYKFKELSYAGRREKVLHKYFPSYLRRLGGNKRHSSLDAELLSSLVECLSQDEQTYRVWRSTHYQLQLVPSRLLIQHLEHQWQLMPRRSQALLRETLASFALPNPSAKPSAEADETCRQSQILLKKMSGRGFPWFLVLVTLAAAVGALVVWDVQGSFQRSRTRQLLKDAGLLSHLEPAIAKGAVYWQDGLSWVGTHTPRLYKQACEQFGPTLDAVWVQALASAAWAWDRAAPARDWLCKQGHPLLQWGDEWVPFCAATVLRAAHEAWATVGVGVSWLLTNLVTGAQLTSAWLTQNVLTGAWSPEKLQGHASDLAATFQGYAVEAYRWLHDQVAQSPVAK
The following text describes a protein:
Function:
ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVRRLARGCWSAFWDYETPKVIVVRNRRLGFVHRMVQLLILLYFVWYVFIVQKSYQDSETGPESSIITKVKGITMSEDKVWDVEEYVKPPEGGSVVSIITRIEVTPSQTLGTCPESMRVHSSTCHSDDDCIAGQLDMQGNGIRTGHCVPYYHGDSKTCEVSAWCPVEDGTSDNHFLGKMAPNFTILIKNSIHYPKFKFSKGNIASQKSDYLKHCTFDQDSDPYCPIFRLGFIVEKAGENFTELAHKGGVIGVIINWNCDLDLSESECNPKYSFRRLDPKYDPASSGYNFRFAKYYKINGTTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSIGVGSFLCDWILLTFMNKNKLYSHKKFDKVRTPKHPSSRWPVTLALVLGQIPPPPSHYSQDQPPSPPSGEGPTLGEGAELPLAVQSPRPCSISALTEQVVDTLGQHMGQRPPVPEPSQQDSTSTDPKGLAQL
The following text describes a protein:
Function:
In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.
Sequence:
MPQATELKSWSALQSHHDTVGRNFVLKDEFKKDPQRFEKLSKTFKNTADNSEILFDFSKNLINEDTIKALVAVAKEAGLEKLRDEMFAGEKINFTEDRAVLHVALRNATSDPINVDGQDVMPGVNKELKHMEEFSEQIRSGEWKGYTGKPLTNIVNIGIGGSDLGPVMVTEALKYYGAREQTLHFVSNIDGTHMAEALRDSDPETTLFLVASKTFTTAETVTQCQLCKRMNTPLEENIPVLGGLLSVWYSDFYGAQTHLVAPFDQYLHRFPAYLQQLSMESNGKAVSRDGKIVRYTTGPILFGEPATNAQHSFFQLVHQGTKLIPTDFIMAAESHNPIDNNKHQKMLASNFFAQAEALMIGKGEDELKAENTPPELYKHKTFLGNRPTTSILAQKITPGTLGALIVYYEHLTFTEGAVWNINSFDQWGVELGKSLAKKIQAELDVSGDVGEHDASTGGLIKAFKQKANI
The following text describes a protein:
Function:
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.
Subcellular Localization:
Endoplasmic reticulum. Membrane; Multi-pass membrane protein.
Sequence:
MVQRNKSSMDYVSLGCCTLAFVLYINTLSAGFVYDDRRAILGNPDVLGTGSWSQMLHNDFWGTPLVDSGSHGSYRPLCVASFKLNYLLDGFKPFGYHLVNVLLHSLATGLVVKLARHLLPAGRSGVAIAGLLFAAHPIHTEAVAGVVGRADLTGCIFYLLALLAYIRHVRWRQWGDRRQWLALAATVLLAAAALLCKETAVTALVVCAIYDIIKGYAGSRDKHRARSLGIIALSLAFIVHCRLTLPRPATLFSTADNPTARSGSLWTRFLTFTYLPVVNFKLLLLPDVLSFDWGMDAIPRLGTVCDRKVALAALFYLALGWALWSSCRALVNRQQSPVRPSGSKTTPNASSFNRKLANKLNLARLRAGEEGSSVSSLPAVQLDDRENGDGGGGGGGGCALCKQDAGLHHTSSCRTLHNNNGLSSIMCGCGYAPEYKYLSLAAPSQLASYFCRTAGSSSSSSSKGTVRTTTTNNNDSASINYNQSFQGAVVGKKFACHWPLGTVGDGASKEKPFPFTTLLTAPADMCSPSLSSSSYASSSSSSSSSSTSSSCASSVRGDSADGSTDEPCLPDEGNSLHNSPAAALVMSVALLALPFLPASNLLFYVGFVVAERILYLPSVGYCLLVGLGAGALIDGGGGGRSSPASGSSISGKLSSYGRGGRRNGPPARCLGTFVRKCLSALVPPGDRSVGGAVCSDGAAVRDDASGSIHRTASDNGSGVSGRYGKFQRTNGMVAPSVNVQAVSGGGGGGGGSVSGKASRPATAGRGGRVGRSTKPFGPRRRQLVLVCVGLLLIAYSAKTVRRNRDWADEESLFRSAVAVNPPKALGNLGSVLSAQGRYQEAKEALKAALNHRPNMADVHYNLGILLQNQQDYNEAVESFRKAIRFRPSLALAYLNLGTSLIALGRCQEAASVLREGTKLDGAGLRDRAAHENARISALLQLGNLYADQGKLQRALAIYREALHTLPERYPPQGIYHRLGDIFARLNQWSEAERFQRAALEAQPDHIAAHLSYGTMLARNSSRTSEAEQWFRRALRLAPNDASVHHHYAEFLSSQRRTEEAFQYRVKAAELAPEDYALVMAAASSLRLLDRKLEAERWYRQAVKLRPQEARAHTNLGAILHLLGRTQEAANSYREALRLQPDDLTTLSNLAKLGVPAIS
The following text describes a protein:
Function:
Together with BHP-pb3, forms the central straight fiber, bearing the receptor binding protein RBP-pb5 at its C-terminus. Upon RBP-pb5 binding to the host receptor FhuA, the central fiber reorganizes and undergoes structural rearrangements that lead to its bending, bringing BHP-pb3 close to the host membrane for anchoring.
Subcellular Localization:
Virion. Note=Component of the tail. Located under the baseplate and the BHP-pb3 trimer.
Sequence:
MISNNAPAKMVLNSVLTGYTLAYIQHSIYSDYDVIGRSFWLKEGSNVTRRDFTGIDTFSVTINNLKPTTTYEVQGAFYDSIIDSELLNAQIGINLSDKQTFKMKSAPRITGARCESEPVDVGVGAPIVYIDTTGEADYCTIELKDNSNANNPWVKYYVGALMPTIMFGGVPIGSYKVRISGQISLPDGVTIDSSGYYEYPNVFEVRYNFVPPAAPINIVFKAARIADGKERYDLRVQWDWNRGAGANVREFVLSYIDSAEFVRTGWTKAQKINVGAAQSATIISFPWKVEHKFKVSSIAWGPDAQDVTDSAVQTFILNESTPLDNSFVNETGIEVNYAYIKGKIKDGSTWKQTFLIDAATGAINIGLLDAEGKAPISFDPVKKIVNVDGSVITKTINAANFVMTNLTGQDNPAIYTQGKTWGDTKSGIWMGMDNVTAKPKLDIGNATQYIRYDGNILRISSEVVIGTPNGDIDIQTGIQGKQTVFIYIIGTSLPAKPTSPAYPPSGWSKTPPNRTSNTQNIYCSTGTLDPVTNQLVSGTSWSDVVQWSGTEGVDGRPGATGQRGPGMYSLAIANLTAWNDSQANSFFTSNFGSGPVKYDVLTEYKSGAPGTAFTRQWNGSAWTSPAMVLHGDMIVNGTVTASKIVANNAFLSQIGVNIIYDRAAALSSNPEGSYKMKIDLQNGYIHIR
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEALNASRPDVIGKLPQLQNMVKRDPVGYRTEFLMQLRHFESEYQLFLLQPTKESAHFGALVSFLSHVAKCFPVDMAAFPEQIMGLLRDNYLVLEPELRKTLVQSLMLLRNRGLVDAITLLKLFFELFRCPDKRLRELLYKHIVSDIRQLNATSRNVKVNKALQNFLFEMLQDESEHAAIKSLQVLMDLFKRKIWHDQRSVNVIATACTSKNTKLLVMALSFFLGIDEDILEDEEKQKKEKKALVAVDFHSHSKKTKKRQRDTLQALSKNKKARKRELDFMATFPAIELLNDPQGVAERQLKLLKSCTERFEVKLLMMNFIGRVLGFHKLVVLPFYPLLQRYLQSHQQNVTAILAYLVQSCHDEIPPEELHPIVKSIAHNFVTERCSSEVIAVGINSMRELFRRIPLLLECEGMDVLVSDLVQYNRARDKTIVMAARGVLNLIRDIHPALLKRKQRGKFHNEAAKPHRFGELVASEGVDGAELLAEAEAAGRFDGEDNKDGWEVASSTSDEDGSEDEWVNMSSDEEDTERGNDDGNSEANDGEAEEESNEEVPEIEQKDRLDARRILTPLDFERIEMLKKERDAALKDPKSRSKRKAEEDAAKASSDATKVNPTDLEGYSKKKRMTQEERLRVVLEGREDYKHKRSGGGTTNTEKKRLKHFMMIKKSKSVQSKVLVSARQVQSQNNRVVKKILKHDAKKRRKI
The following text describes a protein:
Function:
Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
GVPGDVHDEQKQHDINFLLFKVYEVLXDIXLKXVA
The following text describes a protein:
Function:
Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles.
Sequence:
MASVARKLPSKLYAIQAHSSKVTCLDIGETGRVLVTGGQDRNIKLWTFGDEKCFMTLPGHNSSIDCVKFAYSDDFVYSADDTGVIKRWNLNASDSISLFGHMKSVRTLDFYPYSDSYLVSGSNDTSIRLWDVREKVCIKRYRGHMSHVNSVKFSPDGSWIASAGAEGSVIIWDIRMSKLFMEFTERQTPATCVKYHPTDLLMAAGRSDGTVDLYDLEKRQLITQTPGAGGGGGAGAGGGGGGGGQPVRCVTFDESGKCLLVGTAAGITVVGWEPDREYDRIDSNWCQLGDMKIAGTKLLFGTYEDASVTIHAVPLGQLRAFYNPQNPQPPTFTHNQTSRKSFSRGSGKVRLSIGGGAGGGPSAGHSPDAGQDGELGSGNGGGMSPNLNIEMIDEEDATYAGGSAFEFDVPAGHPKCSLEAMGNGGGGSTVAAGGVPAVPTDMPAFPAGPGEGVGGPATVPLVNSHYLVREEMHMYNLNTLDYYPLPKGHVPEPEKEDFPVNNAQPPDYAPKSATQPGTAGYVNGGSAGGGGPAAGKVTSRVSASGRASASGGTDQRRPGSIHGGVGHSRSAGNLVRRLATSKSTLELNKLPLNETFAFKKPISRGSSPIRHQHAHAPPYHGSGSSSSKIQRSESSALITTNAAASLRNGGATNGGGGPARSQHNANVKVQILTKPVRSKTSLDIRHHAGRTTASAGGAEAPSGPASGLYGPQRGGGGGAMHGAGGGIDALMMDYGSASGNVNALMLDQATASATILRYGGGHESSSMEYEIQVLRNEHDTTLQALCNRTALLSAIRNYTKSGDVTGALKVAVRMNDQHILVDVLGAILEKTSQWTLDMCVLLLPKVYDLLQSEYKFHCTRACDTLRVILSTFLPVIRENTDPWGACTIGVDVSREERQSKCLECKNWLLRIRCLPENPKMGSNLQQLQNMIVDI
The following text describes a protein:
Function:
As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex.
Subcellular Localization:
Lysosome membrane.
Sequence:
MAARWSSENVVVEFRDAQATAMSVDCLGQHAVLSGRRFLYIVNLDAPNEGHRKISRQSKWDIGAVQWNPHDSYAYYFAASSNQRVDLYKWKEGNGEVCTSLQGHTRVISDLDWSVFEPDLLVTSSVDTYIYIWDIKDTRKPTVSLSAVAGASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDNEYTLATSSQDNSVRFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRIDSQLQRLCANDILDGVDDLIDGISLLPEPDKALQPQDSEPQHSSGHGDEEALKEDFLNDLLVGKKTDQLGLPQTLQQEFSLINVQIRNVNVEMDAVNRSCTVSVHCGNHRVRMLVMFPVQYPNNAAPSFQFINPTSITASMKAKLLKILKDTSLQKVKRNQSCLEPCLRQLVSWLESVVNQEDSTSSNPYALPNSVTTPLPTFARVSNAYGSYQDSNIPFPRTSGARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHSGLITPMKIRTETPGNLRLYSGSPTRSEKEQVSISSFYYKERMSPRSARRRWSIQAINDFPKSRRWKSKREGTDANNRPIKAAGKVIIQDISCLLPVHKLLGELYILNVNNIQETCQKNAASAMAVGRRDLVQVWSLAMVATDLCLGPKSDPDLEIPWAQHPFGRQLLESLLAHYSQLHDVQTLAMLCSVFEAQSRLQGCPNSYGPFPQRASNLASHSRYPSFTSSGSCSSMSDPGLGTGGWSIANKDTEQTSTPWCESSPDEFRYSNLMYPDHREREKDQHEKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSSPPDPHKGIEFGVYCSHCRSEARGTQCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEWFRTQEVCPTGCGCHCLLESTF
The following text describes a protein:
Function:
Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MCRLAYGLAMIVGQHLLRGATAQAAGRAAALNCCFPYVWRHRPSSSTVAACIRAGLTYSPRPRTTARCDKGRSIYWPDLCRPHAARNSSAKLKMAAAKATEIKALIDAKDMDGLARSVADFDDRQRAEIYAAFRAANGKTASEYLDALFKNGDYKDLMMIVLDDEIDVRCKLIKKAFKGGNDERCLTDTLLTTTPEIYARVKGRYHQLFGDDFESTLRKEIGSKTVWARMVNSWLAFCRSARNNVQGDAEALKTALIGVKHPDTDTVIRLLGTTVPSEWKQISEAFENIAKKTIEQALIEAYKGDDELALCCCNATLHCPARGAAYLLSLACQKKGDTDRCCRITGMLYDQAEQCKVLYAHYGNLAKDIRATMSKNLAEACCVLWHVM
The following text describes a protein:
Function:
Probable transcription factor involved in postembryonic differentiation of the ALA neuron, and regulation of genes that contribute to behavioral quiescence, a sleep-like behavior mediated by ALA. Regulates its own expression and also that of homeodomain ceh-14, together forming an autoregulatory loop in the ALA neuron. Involved in fasciculation-independent longitudinal axonal navigation in many neurons.
Subcellular Localization:
Nucleus.
Sequence:
MMMEYGGYFSSSAVAQQSGDVPTTAPSAVTNSFFYTPQSHNIYHQYATPYLQSGRALTTAHNTSSSSAGNSTSSSSSSSNYRNTTHDSLQAFFNTGLQYQLYQKSQLIGSDTIQRTSSNVLNGLPRSSLVGALCSTGGAPLNPAERRKQRRIRTTFTSGQLKELERSFCETHYPDIYTREEIAMRIDLTEARVQVWFQNRRAKYRKQEKIRRVKDEEEDPLKKEPGQISLEEIIDQI
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol.
Sequence:
MRLYCLSGDLAKPCYIITFKGLRIMLDCGLTEQTVLNFLPLPFVQSLKWSNLPNFVPSRDHDPQMDGELKDCCGRVFVDSTPEFNLPMDKMLDFSEVDVILISNYLNMLALPYITENTGFKGKVYATEPTLQIGRFFLEELVDYIEVSPKACTARLWKEKLHLLPSPLSEAFRAKKWRTIFSLKDVQGSLSKVTIMGYDEKLDILGAFIATPVSSGYCLGSSNWVLSTAHEKICYVSGSSTLTTHPRPINQSALKHADVLIMTGLTQAPTVNPDTKLGELCMNVALTIRNNGSALIPCYPSGVVYDLFECLTQNLENAGLNNVPMFFISPVADSSLAYSNILAEWLSSAKQNKVYLPDDPFPHAFYLRNNKLKHYNHVFSEGFSKDFRQPCVVFCGHPSLRFGDAVHFIEMWGNNPNNSIIFTEPDFPYLQVLAPFQPLAMKAFYCPIDTSLNYQQANKLIKELKPNVLVIPEAYTKPHPSAPNLFIEQPDKKIITFKCGEIIRLPLKRKLDRIYITSELAQKISPKEVAAGVTFSTLTGVLQVKDKVHCIQPCADSVKDETISSNSAPTKEDVLKNVKYEYGSIDVDAVMKKLAQDGFSNIKLDRTGGALTLNLVNEDTVIKFEDNETHIICGGKPTTRLKLRDTIMKCLQSF
The following text describes a protein:
Function:
During centriole duplication, may play a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery, leading to the centriole to centrosome conversion (By similarity). In addition may play a role in the primary cilia assembly (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Recruited to the nascent daughter centriole early in the duplication cycle and localizes to the proximal centriolar lumen just above the cartwheel.
Sequence:
MEVCGEPLIRAAPEPLRDERIQTAELLCADLDLSVSLTPERPADRRRRQVRFNVDPVLITVNPEPRNNQPTARKPPNKDEHGVETDREQSRECDGQQTHEAELNTTLALRAELEEEAEQTFDAEKAVREKLQSSTLTKNHVNSKAAEGLNFPRSQQLYRALVSVSLSRDQLISQALQDRPALAPPTASQNNKFSSPPPEGPDILQFYSPDKMLRETPLLPGDHIPLPRPRPVPRPAHTTFHLHRLHKLWES
The following text describes a protein:
Function:
Involved in gametogenesis and steroidogenesis.
Subcellular Localization:
Secreted.
Sequence:
MPASSYFLLFFFMNFFSPAQSYLLTHCEPVNETVSVEKDGCPKCLAFQTSICSGHCFTKEPVYKSPFSSIYQHVCTYRDVRYETIRLPDCRPGVDPHVTYPVALSCECSLCTMDTSDCTIESLNPDFCMTQKEFILDY
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus. Note=Interactions with MIF proteins prevent nuclear subcellular location and leads to a scattered repartition throughout the cytoplasm.
Domain:
The homeodomain differs form the typical one by having namely 4 instead of 3 extra amino acids inserted in the loop between helix 1 and helix 2.
Sequence:
MELGGKCNAITTTTMISTEVKPHTDPEPEAKPESDPSMALFPIKKENQKPKTRVDQGAKYRECQKNHAASTGGHVVDGCCEFMAGGEEGTLGALKCAACNCHRSFHRKEVYGHRNSKQDHQLMITPAFYSSNSSYKPRVMHPTGEIGRRTSSSSEDMKKILSHRNQNVDGKSLMMMMMRKKKRVRTKINEEQKEKMKEFAERLGWRMQKKDEEEIDKFCRMVNLRRQVFKVWMHNNKQAMKRNNSNISE