lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play a role in protein-protein interactions during tube assembly.
Sequence:
MRVIFVISLVSFMFVTWQTNPVHCRQHKTPQVVDLGYSGAKVETVMKTSDVVYAKPMCHGGRCPPPPPTKTCSKPSSLKAVSRAGHAGYFGTIGSGKYKNNENCWWSIQAPADQRLRLHFESLYLEYGNRYCPYDYVNIHNGKNENGQRLGKYCGIKAPDDIITTGNSAYVRFSTDSSVTKYGFRLRYSIVSCNSLHTIFGSHGEFGTVGPAYGNFEECSWKIEVPNGKRVRLHFKRFHLENNNKYCPYDKLKIYDGSSASASLKGTLCGKRRPKDIESTGKTMFVTFSSDISLTFPGFRIQYSVPASCSVVNELTGPSGTFGTTGSQYENNEVCSWKIEVAQNKRVLLHIYRFNIEVEANCEYDSLTVYKGPNDSAPMLGKYCGETIPTFMVSSGNTMFIKFQTDGSARKPGFWIGYTTG
The following text describes a protein:
Function:
Component of the mitochondrial large ribosomal subunit (mt-LSU). Within the mitochondrial ribosomes, required to direct the nascent polypeptide toward the tunnel exit and position the exit at a distance from the membrane surface.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRKLINTTWAGQLHILGKSVFSEHTSKLHTSIAICAKRNPFLGKLEESFNQSSRSEEKSKKQGIKNYLKKHQRYADYNYQEWRFPKSNRAIDISCTRDIIQPYEDDNSGSKSSLSVRKKLSDLRHDILHNRIVKKRVDNFHRKRFPAEAQDIYIKAHNLLNTPKEERLQNLVTEHAYTDMVKGLDSKTVIWKWNESLEPPRVVRIRASPMITNNNYYGQVTVRFHSKQTLAIYDRFGRLMYGSPDEARNVLEFVVFERHISHPYGCWRIHGKISSDSYQKEPMRKTVAFMKQKPQRIESLEWHEQEEKENHYKWYP
The following text describes a protein:
Function:
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu7 probably implicating CUL3-dependent proteasomal degradation.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere, M line. Note=Colocalizes with ANK1 isoform Mu7 at the M line in differentiated skeletal muscle cells and heart.
Sequence:
MDNGDWGYMMSDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPRPLYPMDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD
The following text describes a protein:
Function:
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity).
Sequence:
MFNPFQIFDLPVDFQLDEKVLNARYLKLQKALHPDNFVSSNALDQRVAMQKSTEVNDALKTLKDPILRAEAIIALNTGEQLDLEQKSTQDVAFLMQQLQWREQLEEVERQQDERALNAFAKEIKQETQSLLTALFESLKSQQWARASQYCDKLRFTHKLSEEIERVEERIFELD
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5. Within the integrator complex, INTS8 is required for the recruitment of protein phosphatase 2A (PP2A) to transcription pause-release checkpoint.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with chromatin and transcription pause-release checkpoint.
Domain:
The WFEF motif is required for the recruitment of protein phosphatase 2A (PP2A) to transcription pause-release checkpoint.
Sequence:
MDDPLKPKPVPLAAETVLWFEFLLDPHKITQHLQRPHPEPSAMELIVQFISMTPNTAQESVGTPGSDLQNLNQTPSNSGPIPGVVGGAPAPTTPTASGGVGMPHSPQRPAEKGLQLNRKQLALKILELKVATWLKWDLDALEKNLPVIMQLALLRDLCTISYGCSLSIPLPNDFDARISAAGNERAARFALTIYHRMLLRMQLIKEQALKAPRPQNTMYQTVDQLQQFLDTPTQPSIEYLQQLCASTKPFYIFHYDSFVPLRCDDIGNGQNYDVMHLITPQELRAQLHYELAQYYLYTKQYVLAREAAAACNTNLQAIPPQTTLYYCHIRPSELEGLLQACGISAEEQSLLEKFQQSLLNNYTDIVSILRMDNRRREIPFISRRQVELDIEGSISTGILKETVQLQLQVAALNVVRNIFEWGSIFGSVEYFEKYRELDCLPPLVEALQEMLPHCTFKEQAALKHFLIDCLLHQGGQSRQLLQTVRGFGLFSSDELQDIDEQMLQATPPVPTNSLASLSDWMCHSKMSRVDVGALERQLISCTNANTVRILLVKLCATAPGKPLWAINPSWDVPQPLKTLIMAMPVSFLQDFSYVLLGKARELATRGNYIDAVSMLSVLKSENQRQEMAANVQLMCKLITWEILHIQITQCLEEWHQKPLDLQSLGGRCKQCLGALQAGDSIVPRPDILESCAIMLLNLTEFPPLLYLDKRAGPLELPLAFAATFIEMEKMKGPKKVCRDAWELMLSMFLNVPKRGSSGVGGISSLQAFLQRIRHQSVFGLAISMIGKVHNILKDDPNHDLSCEYMQLWPTSINNPVSYSLRSVCETLQWLLSEALSYYPQTISWLKMKGDLDLAIGNNESAMRCYVNALVTGTDYCTMPLQRNVADDYVIRKMIRCAANLGCHMQATVLCQFLDEIDYGIVFKNLSEKSSNFTDAMDAYYSCIWDTTLLEFIVNLHAKRGEHSRKLEAISMMGTLELNANNNEEIKRESAMVRKSRFLRALAKQYLL
The following text describes a protein:
Function:
Possesses acidic protease activity. Hydrolyzes casein and azoalbumin in vitro.
Subcellular Localization:
Secreted.
Sequence:
MISDTVIAILAVALVGSTVQAAPVDATATSTSGIIAVPISKSAAQLAREADPVVSLDWLKKTKAQAQYKHKQANARLHSKRATGASVLTDQGSESLWTGPITIGGQSFTVDWDTGSSDLWVPSSACSSAACNAHHKYTLTSTGKKQSGTFSISYGDGSSASGPVYKDNVVASGLQATSQVFGAVTSESSSFSSDPSDGISGLGWPALAQLSGTSYFWSLINQGTVTSPVFSFRLATTNSELYLGGINSAHYTGAITYTPVTQKAYWTIALGGVSVNGAAINPSVSSAIIDTGTTLVYGPTAGVAALYAKIPGSASMADTYGSDYQGYYTFPCSAVPTVALTFGGSSFSVPTSAFNLGTVSSGSKQCVGGIVGQGDGSWLVGDVFLQGVYSIYDVGNARVGFAKTV
The following text describes a protein:
Function:
Na(+)/H(+) antiporter. Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Acts as an Na(+)/H(+) exchanger in the trans-Golgi. Contributes to the regulation of pH regulation of Golgi apparatus, and consequently, in protein trafficking and endosomal morphology (By similarity). In germ cells, plays a crucial role in acrosome biogenesis and sperm development, probably by playing a role in the fusion of the Golgi-derived vesicles that form the acrosomal cap (By similarity). Can also be active at the cell surface of specialized cells. In the small intestine, at the cell membrane, plays a major physiological role in transepithelial absorption of Na(+) and regulates intracellular pH homeostasis of intestinal epithelial cells (By similarity). Acts as an important regulator of mucosal integrity in the intestine and in the stomach, could mediate the pH fluctuation necessary for mucin exocytosis or assist membrane trafficking of other proteins. Plays a role in photoreceptor survival and in the maintenance of intracellular pH homeostasis in retinal pigment epithelium (RPE cells) (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Endosome, multivesicular body membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Intracellular versus plasma membrane-resident location may vary with cell type. Mainly localized to the mid- to trans-Golgi compartments but a proportion is also localized to multivesicular bodies (By similarity). Localized at the apical membrane of polarized gastrointestinal epithelial cells (By similarity). Recruitment to the plasma membrane upon acid stimulation (By similarity).
Sequence:
MGEKMAEEERFPNTTHEGFNVTLHTTLVVTTKLVLPTPGKPILPVQTGEQAQQEEQSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSETCVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAKARRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYEAHYIRRQDLKGFMWLDAKYLNPFFTRRLTQEDLHHGRIQMKTLTNKWYEEVRQGPSGSEDDEQELL
The following text describes a protein:
Function:
May play roles in cilia formation and/or maintenance.
Sequence:
MNLNFLFHIAIIYLFHLVQLLSNGIILNLQVVVLLFQLLLLLQHRQPVLRSLDLLVGGLSQLPGETLDLSPQPLRAGLQQQHTIYGLLFFSCFQKNTTVKAPRAKYTIVGEAIRYVIPGHMQCSIGCGGEDCKYDNPAYWREDQQAIKGLYSSWITEHLLAMSRPSTEIIEKFDVINQFKRNGIKSVINLQMVGEHASCGKPLEPDSGFSYRPEVFMENNIFFYNYGWCDYGVANLTTMLDMVKVMAFALQEGKVAVHCHAGLGRTGVLIACFLAYATRMTANQAISYVRAKRPNSIQTRSQLRCVREFVQFLAPLRTVFSQAEPRSIPVTLSQYLNRQRHMLHGYERKELRHLPKIVQLVCRLLVDIAENRQVIEEDILEAPDIQDIEMTLSVIEKMGPDFHTREPRLPGSPILPRHFNEPPIFYHRKSLSYSDSDLRGLSSQLNLLTQPLTSISKSETKLPSCSSQGQRDYPSEVSHSSTGSLWQVKNQQNDGTIVLKKLKKKVIHRSESVGNNQPPKKGSMLSRWKAEQREERALNGKKYHDKEEEQSEVPFITLQSELSLDGRRLLVAQALAVDLFLEGQEEHKNKVLTWQGELNQGGAWERLCMERDPFVLTGLMWAWLEQLKEPVISIQDAEAMSHNDCDAQTVLDSLDQVRETITCILHCMAQMLTISKEVEVAFLNRTIKAFTWVNNMDMNSEDRRHVYTVHKHFVKNILTFFFGLGCSRCKGVCFQDIYAIYPFK
The following text describes a protein:
Function:
Catalyzes the interconversion between glucose-6-phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA). Has a role in the biosynthesis of all phosphate-containing envelope polymers, since glucose-1-phosphate is the precursor of UDP-glucose, which serves as a glucosyl donor not only for the biosynthesis of LTA but also for wall teichoic acids (WTAs). Is required for biofilm formation. This is likely due to another role of UDP-glucose, which might also act as a metabolic signal regulating biofilm formation or may be involved in some unknown biosynthetic pathway essential for biofilm formation, e.g. the synthesis of an exopolysaccharide.
Sequence:
MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEFGTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFAMEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGDDGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSISVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSPNPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLHYLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEASGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNEYGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTESKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSEDVMKTVDEIVESTAK
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Chromosome, centromere, kinetochore.
Sequence:
MAMHNKATPPQIPDTRRELAELVKRKQELAETLANLERQIYAFEGSYLEDTQMYGNIIRGWDRYLTNQKNSNSKNDRRNRKFKEAERLFSKSSVTSAAAVSALAGVQDQLIEKREPGSGTESDNSPDFQNQENEPSQDDTEDLDGSLSGVKPQKAASSANSGGHHSSHKKRKNKNRHRIDLKLNKKPRSDY
The following text describes a protein:
Function:
Involved in the uptake of iron. Probably responsible for the translocation of the substrate across the membrane; Part of the ABC transporter complex FeuABC/YusV involved in import of the catecholate siderophores bacillibactin and enterobactin.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQYEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFMLLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSGFSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLDTIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGVEHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGENA
The following text describes a protein:
Function:
Cell wall protein involved in development of asexual structures such as phialide and conidium development, and thus required for spore formation. Plays a role as a general stress protectant produced by the fungus in competition with antagonistic bacteria (By similarity).
Subcellular Localization:
Secreted. Secreted, cell wall.
Sequence:
MKLTSTAALASLAVAATAAPSTPETFGLVAIRSGDAVQYAGFNAALGSIFAGLPKQNATCEGTDSGFATFYIKDGALYLYGSEETQEIYVDRSGMGQGLIGYTTGDNASGPRNSERTGWSIDENNHLVFDGNSLIACPNSIDSAYSIWASAGVANPGGNKDCVGIAARVEKTENPIACTYSS
The following text describes a protein:
Function:
Has an essential role in ensuring cytokinesis and septation occur only once during mitosis. It does so by interacting with the ras1 signaling pathways, thereby suppressing them.
Subcellular Localization:
Cytoplasm.
Sequence:
MTEVECWDDDPDFASDVDNASLFTQSIATTSASTSVDDGFSFDDSISRLNSLSISDVPSAHSRVEQWNQQVHNLNHELSSNKNRISSNVEGYEDDFSFDEEGEEGNNEFNTLRPNKYQDADVDEFNTIRASETASQRPPIPFSSDTLKKTYLSSENDARYPSVSDSPYCESEGFSSFEDDFEIDPDTDLNSILHRKQNRMDPKASFSSVEQSSLRTPSSAHNDDGFWDDFDIDFNNETESIFRKKIRSPNTINQKHPYISSTISYQPNVHQDAKYYPLCKDIFPSLANENPHSDNPNLKYSSKTLSKRDTSSHYPETLKASSKHSSPVKGNSSISSTWTPSNLKIYHSKNSMGLMDLDALKTVASNSKYRTKPKNCKTYGDGTELDTLDELPVDYEFELKLRKKQTTKVSGTPKSKHAGSTQEWHSHTTPRSTSKHENNLNNITNSAKNEHIRSQRQHKTHAAPSKELTKESLSNDQLSVKEKRRHHKKAPTLIQNLNSPRTPKIVGKMRYNPTKHCWEGNDYAIRDFDTPISPSRPALISNISTKKGIQVVGNMVYDPTRLRWIDNSISGQEAEDPFSGFDDLEDTDSTSQYLNENSGSFNGSINSIINFPDMSEIYDVGPEFEKKQFSEDIQWRKRIDGWFFSFKNDDRSRLWELYNILNAEQ
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLCENCHKNKANLKRFETGMKVCKECFAYLFEEEVYETCTKYNLIQPGDVVGIGVSGGKDSTCLLHVLHTINQRHNMGFQIHMICIDEGIVGYRDNALEAVKFNKEKYGLPCTIIPFNELFGWNLDDIYKATHTKETCTYCGIFRRRSLDIAAARVGANKVAVGHNANDVAETVLLNVLRGDINRFGRSVDIKTDGISSNVEEGTVAPRIKPFAFQTQRDIVLYVHFQNLRYYAVECPYAVTAFRRFSREYLVEKEKTDPGVMRRIIEGSIKYQNQFEKEAPNIGFCEKCGAPSNHKICMACNLIQRLADAHPKVQVVEDSEKQNTK
The following text describes a protein:
Function:
Activates the seven peptidyl carrier protein (PCP) domains of the first three subunits (SrfAA, SrfAB and SrfAC) of surfactin synthetase by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue. Required for cells of B.subtilis to become producers of the lipopeptide antibiotics surfactin and plipastatin B1.
Sequence:
MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRTLLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQPIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQEGKGLSLPLDSFSVRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAAHPDFPEDITMVSYEELL
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal C-A-A-L where A is an aliphatic amino acid. In particular it modifies the GTP-binding component of the 1,3-beta-D-glucan synthase.
Sequence:
MELTRAKHIAFFKRHLILFPTPYEEHDCERTVLAFFCLLGLDLLNALNTIDDDDKKSWIEWIYKNYVTKESKGIKYSGFQAYRTGIQPISFEQEPQLAGTVFSICCLLFLGDNLSRIDRDLIKNFVELCKTSQGHFRSIAVPSCSDQDMRQLYMATTIASLLDFSLSDPLCSIQYIKSCQRYEGGFSLLPYGEAHAGATFCALASWSLILKMIPNSSLNTSNQSYNLMDCVPKVERLIRWLASRQLSSGGLNGRTNKDVDTCYAYWVLSSLKLLDALPFIDGGELEKYLLLHAQHALGGFSKTPGEFPDVLHSALGLYAMAYQDDKSFPKVNADIHMTSKYINICRDCIQAAKGK
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Essential for the structural integrity of the CSN holocomplex.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASSSSGLTFKLHPLVIVNISDHHTRVKSQSQPPTANGGDATSASSSSPALSSPRVFGCVIGVQRGRTVEIFNSFELLYDPSNHSLDRTFLEKKQELYKKVFPNFYILGWYSTGADAEESDMHIHKALMDINESPVYVLLNPLINHAQKDLPVNIYESELHVIDGIPQLIFVRSSYTIETVEAERISVDHVAHLKPSDGGSAATQLAAHLTGIHSAIKMLNSRIRVLHHYLIAMQKGEIPYENSLLRQVSSLLRRLPAIESEKFQDDFLMEYNDTLLISYLAMFTDCSSTMNDVVDKINIAYDRHSRRGGRTAFI
The following text describes a protein:
Function:
Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra.
Subcellular Localization:
Secreted.
Sequence:
MRCTSPAALVTFCAGLWISNHVLAQGLEAGVRSRADCEVCKEFLNRFYNSLLTRGIDFSVDTIEEELISFCADTKGKENRLCYYLGATKDSATKILGEVTRPMSVHMPTVKICEKLKKMDSQICELKYEKKLDLESVDLWKMRVAELKQILHSWGEECRACAEKHDYVNLIKELAPKYVETRPQTEL
The following text describes a protein:
Function:
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MLCAISGEAPQVPVVSPKSGSVFERRLIEAYIAENGKDPVNGEELSVDELIEVKSQRVVRPRPPTLTSIPSLLSVFQEEWDALALETYTLRQTLAQTRQELSAALYQHDAAVRVIARLTKERDEARDALSKVTVSAGRAGGEEAMQVDSTGLPDAVLARIESTQVSLSKTRRKRPIPEGWATSDALSTYKPTETSKPLCQGGKALAVNAAGEMALVGGADGTVGVYSLSEKRVVGNLHTSGPVTSAVWAGDKAVIASSTGFIQVFEDGKELANFASHAGSATDLALHATGDIVGSVGVDKSYVLYDLTTNSVITQIFTDSSLHTVAFHPDGHLIAAGGADGQIKIFDVKSGTAAANYAMSGPVKCLYFSENGTFLAAVADNSTVLSIWDLRSSKEIKVLETGSQIDSICWDYTGQFLLTGGPSGVTVQQYSKASKEWSEPLRSAVPAVAVAWGSAAQSIVVLNSEGGVTVLTAQES
The following text describes a protein:
Function:
Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export.
Subcellular Localization:
Cytoplasm. Nucleus speckle.
Sequence:
MSQFGGGKPPGQWHRPAAPGGAPQLSGFPTVNFGGVPMVGMGVPMGMVNQAAFSSPNVLGMQGIMGAVPQQQLGQQQPSFQQQNGLQQGAASLQQGTGAKNQRTFVGVVTKMLDTYGFVDDDVFFQHSVIRGSHPRVGDKVMVEANYNPSMPFKWNAYRIQLLNAATQQDQVRQAPPQQQLPPQRQETQRWGGNQAANDRGDRNGRGNESPLHRSNAPRRHSPPPRRQSPPPRRSSPKRQPRESRRSPPPRRASPRRAASPAVQPAKNDRKRERSPSGSVALSIRRDSASPPRRRARIIPRYECRIQKPTLLSQIVSGSVLRHRYSKLYLPSDYVDLSFDWVRTIQLDMSMDLNNAIQFHVFNKDVDWIGDALPELEPEDADHRHQVKVLLLSHAGKTEVVKKSFCLMADGTTDDHQEPQSLLKNLHFLVGARGKETMGIGGSWSPSLDGADPTSTTTMIRTAVRTTRALTGIDLSSVSQWFSMVQIRYYRADKQRIDHVNFLLPDTQSLALDDATWSSAEASIGEQLKAKLAEVDALKIEEEPEVVEMVEAVEPAAEVVVTPEAAVVTAETVAAPEDAPSDVKESIVLLYMVENENDVSMNSETGEADKPIVAGQGPTNWSKLDPKSMKVAELRVELELRGLETKGIKTLLVQRLQTALDSEKSTEAAASKDVEMKDVKDEVKQEAGAVAGEENPAAFIAPPIEETKAKTEAEAKKEQEEADKKKKKEEQLEKEKKDKRDALEKHYQLPKDKKVLVFPSKTFKSGKFDCKVLSLSSLLDYRHDDNKESQFEVSLFAEAFKEMIERNSAFTIYETLVNCGDRDAEKKRRDEAREKTVEVVVPEASEDAKAKTEGTEEKKEEEKEVKKEEKKEKVEVKSVVANRTVYEAFSLFDANLCGYITEKDIEEILYHGEFGISRGQIQKLAKKLSVRDRINYRHLTDVLTDMDGNVRHTPGGADDVVETDDLIRGYGVNLAKSLEVPTSDAAASATVGSDGVVIINGAAVNVGQKLKMLKQVEKERDEAKATVNEQISLIDQLREAKAEIEKKKKDIDAHYHKSNKKLNETTAQLKTSQDDNSSLKQALQDCKRHADRIFSVVEKAMPAPKKEKKEEKEKSAEKKDEKLAEKTAEKPAEEASTTTTAASESATSTVSAAPAEQSSAAEPIAIDEQSSEEKPEASAEEKKEQ
The following text describes a protein:
Function:
Cell-cell adhesion during early development.
Subcellular Localization:
Cell surface.
Sequence:
MVDLKITLVNEDGESTISGKGHPLPAPLIFPPIYIFRFTQYQTEGKLWDKNEFQIKSGKIEFDGEEYDIPESKGTWSKDDEENAIDVNLHLFRPPEKFFPKN
The following text describes a protein:
Function:
Plays a role in cytoplasmic pre-assembly of axonemal dynein.
Subcellular Localization:
Cytoplasm. Golgi apparatus, trans-Golgi network. Note=Localized to the cytoplasm of spermatogenic cells.
Sequence:
MESENAEAENVVTGNLEAKSKEGKNMQFVTLSSAWSLQALSSLLNPEEEDGFDFEQGQCSFTIGAMGPGNIGPPKAKESKAIPEPRSDESENIWNPEEVPEGAEHDDIWDVREIPDYEIVFQQTVGTEDVYLGLTRKDPSTACCQELVVKIKLPNTNPSEIQIDIQEMLLDLRTPRKKLLVNFPQPVERNSARASYIWEAETLEVRMTVQRDLDFNIS
The following text describes a protein:
Function:
Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions.
Subcellular Localization:
Periplasm.
Sequence:
MKNKDSLHVSRRRFLAQLGGLTVAGMLGPSLLTPRSARAADAVAPGAATKEGILTGSHWGAIRATVVDGRFVAAKPFEQDKYPSKMIAGLPDHVHNAARIRYPMVRVDWMRKGHQSDTSQRGDNRFVRVSWDEALDLFYQELERVQKTYGPSALLTASGWQSTGMFHNASGMLARAIALHGNSVSTGGDYSTGAAQVILPRVVGSMEVYEQQTSWPLVLQNSKTIVLWGSDMVKNQQANWWCPDHDVYQYYEQLKEKVASGAISVISIDPVVTSTHDYLGRDKVKHIAINPQTDVPLQLALAHTLYSEKLYDKNFLDNYCVGFDQFLPYLLGEKDGQPKDAAWAEKLCGIDADTIRALARQMAGDRTQIIAGWCVQRMQHGEQWSWMVVVLAAMLGQIGLPGGGFGFGWHYNGAGTPGRKGIILSGFSGSTTVPPVHDSTDYKGYSSTIPIARFMDAILEPGKIINWNGKSVKLPPLKMCVFAGTNPFHRHQQINRIIEGWRKLETVIAIDNQWTSTCRFADIVLPATTQFERNDLDQFGNHSNRGIIAMKQVVSPQFEARNDFDIFRDLCRRFNREAAFTEGLDEMGWLKRIWQEGSQQGKGRGIHLPIFEVFWNQQEYIEFDHPQMFVRHQAFREDPDLEPLGTPSGLIEIYSKTIADMQYDDCQGHPMWFEKIERSHGGPGSQRWPLHLQSVHPDFRLHSQLCESETLRQQYAVGGKEPVFINPQDASARGIRNGDIVRVFNARGQVLAGAVVSDRYAPGVARIHEGAWYDPDKGGDLNALCKYGNPNVLTLDIGTSQLAQATSAHTTLVEIEKYTGPMDNVTAFNGPVEMVAQCEYVPASQGNPHD
The following text describes a protein:
Function:
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
Subcellular Localization:
Cytoplasm.
Sequence:
MGQTPTIAINHLGCEKNRIDSEHMLGLLVEAGYQVDANEELADYVIVNTCSFIQDARQESVRTLVELAEAKKKIVISGCLAQHFQEQLLEEIPEAVAVVGTGDYQNIVDIIRRTEQGQRVKAISPNPSFIADENLPRYRTTNEAIAYLRVAEGCDYRCAFCIIPQLRGKQRSRPIESIVAEAEQLASQGVKELILISQITTNYGLDLYGEPKLAELLQALGKVDIPWIRIHYAYPTGLTPKVIEAIRDTPNVLPYLDLPLQHSHPDILRAMNRPWQGQVNDDIITRLKTALPDAVLRTTFIVGFPGETEEHFGHLLDFVQRHQFDHVGVFTFSPEEGTAAFDLPNAVPEEVMGDRRDRLMALQQPISAQKNAACLGQTLDVLIEQENPSTGEFIGRSTRFAPEVDGLVYVKGNANLNEIVPVVITATDDYDLYGMTAEEAKVF
The following text describes a protein:
Function:
Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSALNKKSFLTYLKEGGIYVVLLVLLAIIIFQDPTFLSLLNLSNILTQSSVRIIIALGVAGLIVTQGTDLSAGRQVGLAAVVAATLLQSMDNANKVFPEMATMPIALVILIVCAIGAVIGLINGLIIAYLNVTPFITTLGTMIIVYGINSLYYDFVGASPISGFDSGFSTFAQGFVALGSFRLSYITFYALIAVAFVWVLWNKTRFGKNIFAIGGNPEAAKVSGVNVGLNLLMIYALSGVFYAFGGMLEAGRIGSATNNLGFMYELDAIAACVVGGVSFSGGVGTVIGVVTGVIIFTVINYGLTYIGVNPYWQYIIKGAIIIFAVALDSLKYARKK
The following text describes a protein:
Function:
Involved in the transport of molybdenum into the cell.
Subcellular Localization:
Periplasm.
Sequence:
MTQFPQTLRAGATALALVMGLALPAAAGEVIAAVAANFTEPAKEIGALFTEKTGHTVTYAFGPSGQFYTQITQGAPFEVFLSADASRPKKAVEEGYAVPGSDFTYAVGKLVLWSADPARVDDKGAVLKTDLEHVAIADPKSAPYGAAAIEVMQKLGVYETLEPKLVTGKSISQAYEFAATGNAPVGFVAYSQVIGKEGGSSWMVPQDLYKPIKQDAVLLKTGAEDAAAKAYLDFLKTPEALEIIRKYGYVTE