lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Chromatin-binding protein involved in the organization of active promoters and insulators. Essential for the activity of heterochromatin promoters; primarily binds to specific motifs within promoters of housekeeping genes. May also associate to a lesser extent with promoters in euchromatin. Mediates recruitment of Cp190, a multifunctional protein involved in the recruitment of transcription complexes, the creation of open chromatin regions and the activity of insulators. Cooperates with pita and su(Hw) to recruit Cp190 and regulate insulator function at the front-ultraabdominal (Fub) boundary. May cooperate with other C2H2 zinc finger proteins, such as M1BP, to recruit CP190 to promoters. May be involved in cellular organization and development of the eye.
Miscellaneous:
MISCELLANEOUS: The overgrowth of red pigmented tissue in the eyes of mutant flies is reminiscent of 'Clifford the Big Red Dog', a character from an American children's book.
Subcellular Localization:
Nucleus. Chromosome. Nucleus, nucleoplasm. Note=Binds to specific bands on both euchromatin and heterochromatin regions of polytene chromosomes. Roughly equally distributed between chromatin and the nucleoplasm.
Domain:
Possesses 2 MADF domains, the negatively charged MADF1 and the positively charged MADF2. Both MADF domains are essential for protein function. MADF2 is important for recruitment to heterochromatin and may mediate interaction with other proteins; Possesses a C-terminal cluster of 6 C2H2-type zinc fingers. This cluster of zinc fingers is essential for protein function and sufficient for recognition and binding of specific DNA motifs in chromatin.
Sequence:
MELCGNVMTNSKYEMFRLKCLYCSIESELKDWELFIVHVKSAHYCEDEDVRINEIKEDTEELYSVVDAADPAIAYGPDEFFEVIENSNGVDQWMEADSKDIQYEEDATAWSAATNNSWEFGPGGSSLELPAGKEVTQMDESSQNHIPLNTDDDDVDCSDFFMSEDDLAPPRKPGRPPRRTRPGQVFKFKVSFIRSNPRVLHLIQAYKEHPCLWNPSDEHYQDEPARSMAYEAIMERMDRKANVLFTVEELKKTLEQLHVQYTLALETKQRGKLVGLAARYFAKCEFLSVAPVVTPRENEEDNDLTAIKLNFKEENLITTSFIETYANYPVLYNQALPDFGSIEIRADAFKRMAKEFQPVVKANETDVYIAVNKLRRWLYDAIRRLKSKELIQKCSKQEVQYLQMCSFLPAKGSESQVLYCDYCDKRFHGDYNLRVHIVKAHEVGDLPYLCSFCPRRFDRHVDMDRHKLRSHFERKLKCQYCEKSFAVDTDLKVHTLIHTGERPHVCDICGKTFRLKLLLDHHVNGVHLNIRPYSCNMCTKTFRKKFELANHIKGHLNIRDKKCEYCDATFYDHSSLSRHRRSHRSE
The following text describes a protein:
Function:
Selectively catalyzes the oxidative deamination of acidic amino acids. Protects the organism from the toxicity of D-amino acids (By similarity). Enables the organism to utilize D-amino acids as a source of nutrients. Enables the organism to utilize D-aspartate as a nitrogen source.
Sequence:
MATVCVVGSGILGLAVASCLLEKTNVNIVIISDDFPHESSHDLKYSPFFTSPWAGAHFRPFPSVTEFDQRHVEYTRATYGHFKKLAAFEPQEETSIRFLEGTDLVERGHPNFEYYSELKQGYREEIEDFVVNDWEHGFSASYKTWVLNAPFFLSYLFKKLRSNPRVTLKQGKLNTLREAFTENAAKNDQSPDLGANGYNYVFNCTGLGLQMNGGWDPACYVIRGQTLLLKVPSGPHLQKTVTHQSKEGQWTFFIPRPLSNPESPTEDYVILGGTKQEKDFDSGSPRSQDSLDILTRADRLFPELKDAKTGHFQVIQPNVGFRPSRKGGVRVEREKVPDVENSFAYHCYGAGGMGYELSFGVAFAVVDLFLDDYNQ
The following text describes a protein:
Function:
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Transports folate across the inner membranes of mitochondria (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MVNGEEYVETPNLIHDEETRKDVKFNLGIELLAGTLAGVSSCILFYPLECVEAKLQVQSSSTAVAATMLGLKKNGGSGSGSSSSSSISHQTPNGPIAMAKSILRNEGFKGFYQGVSPTILGNAVNWGVYFSIYRATNHWWNSTDINGNQYQGPAWVGHSVSAITAGVITTAIVNPFWVLKIRLATSKKYSGMKHAFQSILRSEGVGGFWKGVGVSFIGVSEGLFQFVSYEYILNQMKESNLKMNGGELSVGNYLFAGGTARLIAGVLTYPYLLIRSSLQSETCPYKSMSEAVKGIYKTNGIKGFYKGIGPNLARSIPPAAFMLYIVEFFRDTLTNFSQ
The following text describes a protein:
Function:
Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
Sequence:
MSQEISYTPDVAELLDFDKKHIWHPYTSLSSPLNVYPVKSAHGCKLVLDTDSPVDVEVIDAMSSWWCVIHGYNNPELNEALTKQMLKFSHVLLGGFTHKGAVNLVQKLLKVIDEPSLQYCFLADSGSVAVEVALKMALQSNMSGEATKNRTKFLTIKNGYHGDTFGAMSVCDPENSMHHIYNDRLSENIFAQAPSIVDGLPTSQNGFEDHWNAEEVTDLKKQFELHSDKICAVILEPILQGAGGLRPYHPQFLIEVQKLCNQYDVLFIMDEIATGFGRTGEIFAFKHCQKYQDQHGISPSDQIKVVPDILCVGKGLTSGYMTMSAVVVNDKVASRISSPNSPTGGCFMHGPTFMGNALACSVAEKSMDILLRGEWRKQVSAIENQIYRELYQYIKNPDNGLIGTVVKRVSVIGAVGIVELYKKTDPEWFQKKFISKGVHIRPFNCLCYIMPPYVITTEELTKVNQVLIEVLHEWKSHINQ
The following text describes a protein:
Function:
Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis.
Subcellular Localization:
Nucleus.
Sequence:
MASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSDYGGETIPGPAFDPASHPAPAPSPSSSSVFPPVMPSRQIVERQPRMLDFRVEYRDRNVDVVLEDSCTVGEIKQILENELQIPMSKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTIQEVKRNVYDLTSIPVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPTQTRELSEEQSTDVHMVSDSDGDDFEDASEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDANRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERRFLASSKLQIVFDFVASKGFPWDEFKLLSTFPRRDVTQLDPNKSLLEVKLFPQETLFLEAKE
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MERIGYDLYLEEQSRNGFVSAQPETKRLGRRSLSRIQQAAMATKVQRIMTQPIVQPDIQIPSKCKLYLHFKFHSMVCLDELADFLSFMLCMKQKARIQIWLFEQKDLRIEGRIIGFDEYMNLVLEDAEEVSIKKKTRKALGQKDSVERGQHYSDDEYV
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MLALRCRPRLLGLLPVPRSAPLRLPAARACSGGGSARNPSSSSRNPLVYLDVGADGQPLGRVVLELNADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPAFMCQLGWSGHPSDVRIASQENSNVSMARDWGWGWQPMGSSGHSSPWTPQASYEEGCQLLGGLCPGSTNHREATGPGDFTNHNGTGGKSIYGSRFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIKTDWLDGKHVVFGHVKEGMDVVKKIESFGSKSGKTSKKIVITDCGQLS
The following text describes a protein:
Function:
Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll.
Subcellular Localization:
Cell membrane. Cytoplasm. Note=Associates with the plasma membrane during interphase syncytial blastoderm embryos, more specifically at the membrane invaginations around the nuclei.
Sequence:
MSGVQTAEAEAQAQNQANGNRTRSRSHLDNTMAIRLLPLPVRAQLCAHLDALDVWQQLATAVKLYPDQVEQISSQKQRGRSASNEFLNIWGGQYNHTVQTLFALFKKLKLHNAMRLIKDYVSEDLHKYIPRSVPTISELRAAPDSSAKVNNGPPFPSSSGVSNSNNNRTSTTATEEIPSLESLGNIHISTVQRAAESLLEIDYAELENATDGWSPDNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKSLDAVVEVNKVFGTKIYLPPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENETKKNLLDYVKQQWRQNRMELLEKHLAAPMGKELDMCMCAIEAGLHCTALDPQDRPSMNAVLKRFEPFVTD
The following text describes a protein:
Function:
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
Subcellular Localization:
Membrane.
Sequence:
MKYVLSALLVIAGLFVWFWFSAPERATQFGAWTPQLRALAVIVGLAAGAFVFLGTGKGRETREFMSESRFELRKVVWPTRQEAIRTTWVVIVVVIILSLLLGGFDFVIQKLTQWFLAR
The following text describes a protein:
Function:
May help in the organization of the PsaE and PsaF subunits.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MRDIKTYLSVAPVLSTLWFGALAGLLIEINRLFPDALSFPFFSF
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imid ic peptide bonds in oligopeptides. Thought to function as a catalyst in the folding and modification of cuticle collagens (By similarity).
Sequence:
MSSLEKRVFLDMALDEKPIGRIEIKLFTSEAPKTCENFRALCTGEVGMAPNNKARLHYKGNEIHRVVKKFMIQGGDITDGDGRGGFSIYGRYFDDEKFVLKHSKPYLLSMANKGPNSNSSQFFITTAPAPHCNGKHVVFGEVIKGREVVDVLDNLEVDGKSKPIAKVRIFNSGELVKKKKPSKTKEELAALEERKRQEAKKDIPDIPKSWLYRDNEERESDFSSKTESSRVRSRSKSPSNNYETRRGHMANSRGDRNRRTQRADRKDDFGIAVRGRGGVQFRRVRYVTPEHWRRNAPSKWQQGSYTHPVDLQP
The following text describes a protein:
Function:
Together with sorf-2 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-2 and the sorf-1-sorf-2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels.
Subcellular Localization:
Early endosome. Late endosome. Cytoplasm.
Sequence:
MSHVSNSTDEVVRNYLAAKSMVTSLKAFDQESSFAKEANYQVDRCIDEMTDAIDKHDVDTLCAMWESWNARVFHSLDTEGIKQAQCYEASAYRLFLVRCVQKKNISKCNEFFRKMSSLTLNNPQWADWFAFPYNHHAKDTEPFRKYFDKTWIEIYYVSLHNFLSTSLANVSPSVIGTIVEGIARDPTGNDHVDFDEDLIDDFAVIAQCSAPVKRGHSKPSLRNLLKSLTSSKKPSPSTD
The following text describes a protein:
Function:
Forms a one-to-one complex with ATPase to inhibit the enzyme activity completely.
Subcellular Localization:
Mitochondrion.
Sequence:
MYKYCFRKPACISYRGIRFMSKASDTDPTLANASSAKRSAFESREKAKEDFFVHQHEIEQLRKLKESLKLHREELDELESRVDKKMKSNE
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MEPSSYAAEKKGKGGIRRVINAFGYSIDGIAAAYRYEAAFRQVLWLNVLLVCAAFFWVSETAVRLPLIIASFVSVIVELFNTAVEAAVDHTSTEKHELAKLAKDAGSAAQLFAMLMLAAVWLSALFG
The following text describes a protein:
Function:
Bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5-meC) and 5-hydroxymethylcytosine (5-hmeC), leaving an apyrimidinic (AP) site that is subsequently incised by the lyase activity. Is responsible for the demethylation of methylated cytosine residues of Tos17 retrotransposon DNA. Demethylation of Tos17 cytosine residues promotes its transposition. May be involved in seed development.
Subcellular Localization:
Nucleus.
Sequence:
MAKDENPSYLHLIFLSSRIRVFILDPPLSLPLSHGQCELQVVEEAAMDPSGLNLQGNPAENQESWTSGVSVGRGTPNLGVGTAVAGRSCPSSTLFPGSSLSSTALLNTMHEGSFPQTALVAGSVSSADEQHGAPPVRPSYNLPAGCTQVPISILVFHRRLTGRGSRCRSPQSRSFMPAPALSGVSEADGAYGPIPQSDFLSLRGPSEVFPGDMAMNHSEPATSYGYNSEYAPMHLQPNGLYTEASNTESEREASQLQQSAEAVICDSLSKLESAMEKIQGQNPQESSGLVAEGSADDNIHKYHQKAKRARTQITHSDKIDLPTQAVSACKEKTITQIEMQIADAERTEALKGEDAPAQKLKTRRRKHRPKVIREDRPAKKQMATTSEEKPLNQKPKRKYVRKNRNPSSLEKCAEPFSDHSISRESRTTVRSSIASVRRRLQFEFGEHGVQRDQSSMTNSWYQNQEKPVNAESSLCSVTKSSVQVEHGQELHMENSPEGLFFGINSKLNKILDEYIHLPEAAPKPSEQIPLAASGHVSEELARKQYDVRHTHDPDSTSYNIERSGLITTKGHKKDLDLNYSNTNGFQMYCSASLLPEMDSTKGSMTKVSKMDKNKKRHYGGESSLAGTQSSIIMRTAAEMLAVYQACGIKKKRSARVRRNSFLSVMDLEKNTSQESTRLPRSCMEALYESSYIKFMTKKRSQKARLNSPNSIQPNIDQKNRFSSETVFSGGFNGLKRSEETFQKTLPQIPDDKRINLDIHCKVPVESSPNTSTPPYMDYLQGVTSKFRYFDLNTEQVHKTEMHLSQTMPSLSSLGATNYLPNALVPYVGGAVVPYQTQFHLVKKQRPRAKVDLDFETTRVWNLLMGKAADPVDGTDVDKERWWKQEREVFQGRANSFIARMRLVQGDRRFSPWKGSVVDSVVGVFLTQNVADHLSSSAYMALAASFPTGSHGNCNDGIAGQDNEEIISTSAVGDRGTFEFFYNGSRPDIGLNFEFSMACEKIHMEPKDNTTVNELTKGENYSLHCKESAGSLCDHETEIDHKAKSISDFSAVELTACMKNLHATQFQKEISLSQSVVTSESILQPGLPLSSGMDHARRNFVGSISDTASQQVGSNFDDGKSLTGNDVTANETEYHGIKAAATNNYVVDEPGIPSGSSLYPFFSAIDCHQLDGRNDTHVSSTSPNCSICSASSNFKIGTIEENSSLFMPFDAHLAQRNGNMIVDTNLSSALESTELPVKLLHCGKRSCYEASEFQDHESLYATGGVIPETATKADDSTLKSGFASFNGLPDTAAQASKPKKSRTTSKKNSENFDWDKLRRQACGNYQMKERIFDRRDSVDWEAVRCADVQRISHAIRERGMNNVLAERIQKFLNRLVTDHGSIDLEWLRDVPPDSAKDYLLSIRGLGLKSVECVRLLTLHHLAFPVDTNVGRICVRLGWVPIQPLPESLQLHLLELYPVLETIQKYLWPRLCKLDQQTLYELHYQMITFGKVFCTKSKPNCNACPMRSECRHFASAFASARLALPSPQDKRLVNLSNQFAFHNGTMPTPNSTPLPQLEGSIHARDVHANNTNPIIEEPASPREEECRELLENDIEDFDEDTDEIPIIKLNMEAFSQNLENCIKESNKDFQSDDITKALVAISNEAASIPVPKLKNVHRLRTEHYVYELPDSHPLMQQLALDQREPDDPSPYLLAIWTPDELKDTREAPKPCCNPQTEGGLCSNEMCHNCVSERENQYRYVRGTVLVPCRTAMRGSFPLNGTYFQVNEVFADHSSSHNPINIPREQLWNLHRRMVYFGTSVPTIFKGLTTEEIQHCFWRGFVCVRGFNMETRAPRPLCPHFHLAASKLRRSSKKAATEQTH
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKLLLLLLVVVAVATATEEATSVLDGGLQGVLRFLFGGSAEVKDFFLNTFETRVHHWTNHRANAADFIAQLNTIEPLVESLTSMDDFIERFDLWGEDIMVRTNGGEISDILTTAETVDEPFLRGLLDDGNSFVIKTELHQSHGSDLERQLTTLFATTVAVHGYVTPTGAQALKPHTDPYDVLVIQTYGEKQWTICTPQPAGAQNRTDAEKAQLQEIVRHSIQGCTQYEAWQLAKMECQAITLKAGDVLYLPKGIIHYATTTESMGSTHITLSLERLTHSWLALFGRACGLGLDRATCQQYEDVLLTASLTPNGLAWLNLAAMPAVETDPTTAVCERLNYLMLGDEPTSLVNLLADDHNRKLNMYARSNKELRALLTTILDCSAPDQVIFAMRQTHRDSIKRRETDHRPPCYYASSCNDYSSCDCNDNCDDNCNIWGDNCDAACDGSCVWSLLTVLSVSYSDCDSGVRCKNGYYVSNYWRGECTDCPSGKYGDDGYNCGDCWPGKYSSGSRSTYCSSCPAGKYTDQYTQSSCKNAGQGYYVSSSSSSSPWSCAPGKYTDETTATSCKDCSSANFPGTYQDQYGQASCKTCPEGKYAVGDRATSCVDGVGVLVQPIMSARSMELVIENSGPAREGFRVTLGIWRNDEYAWDTAAGYPKEYDADQTGSSYDAQTRITLNYLIPGTYYYIKVEGRQNGGYPDSFEYPQAQTACACGASEVTGAPADVTTRQHRGRVFFAFSDMSYCEDGFLLYRDGSSFTSGYDVKASQACERRYAPETIYDDVATSSELQVGHTYQYCISAYSKTSFVWAEDSGLTGSYESAQTCISHQVLWEAELTGRVQLTDAAGNLAVADTNIEWFYERNGVFVLGGNLTTDADGRFAVYVKTDLLGTEQEMLVLRPSKTSGTVQHRYTCNGLPCTEQRILVKALTFDQETTFVDATTVPFEGSVFVKGTEHANYALGCPLRNARVCLYNHHAHTALGCARTSITGYYVVPVAAGLTVYPVVEYNNHTFERVNTGRAPEGRYDSVSLAGEALTYDYYAIKSDEVSQPTIFIDTSAATMTMQMAGGRCNRTLGTTTVQITYATCLATWSKDITFSTYEHVVDLPQQEFFVELMGVEHDSEILGETVPAFFEEHGGKKLTIDLKAEEPDTARWEFHPEPQVTVQLSGDRSGECSFAVLEREAPTTISVTAIEPFWSTIESCSWVEGNITLVNQIGETQETVTALLRQKIINAEKAARLGRCAGTGCYVPLELASDDAGRTFHSAHVAFEAMGGEPELVMEVEGVANAKLLTAQLDTAFHSVSKLVPVVVTGDKLISELFTMDFPEYFPLMILYDPPGGSSYSYYSNTVSSLRVRHREFAAFKGAYVAEKVSWTWDVESSLCAGFGVEACTKVAKSEGGAGLDVAATSMSADVKASLNGDDSVTFSTTISVQTSDDLGSPSGHMFITPALTVRYIETREVLFNASACSTEVIEKVTWSLGDSGTNTNSFTIKMYADIRDAEIPTLENNLVHAEADLASAMTSGTQAEKDEAQEKVDKLKEAITGWKGILNYTDEVLYNASTGALEPLTGLMPGELFDAARDLDRKPDGKAADELEKYSAISFMGGGQLYSYEESVGVANSTNTGTMMHDEGTVGGFVENKMAIAGTGPAFEIGIGYQMSADRADVTTKEKSSESVRGFVLGDGDAGDKFVVKISRDPIYDTFVFTTVAGSSKCPHEENTYAREQPRLSIQSQPTGPVAPGHSALLHIRLINDANEANQFQLYVRDIEGLDVRMNDETLLGGRFFEQMAPYSEYEEVVHVTPIEGQTSVTFKMGFRSQCEHDTFLVTGSWSPASFQASEHEITIDFMQPCSTIEWTGDVAKSGRVVINTNHADAYYPFLARNPGAPDSFWADDARLEGVNLEFRPYGSTSWTTAVSGPVTESRFGYASLDWQVENLADGRYEVRLSTQCESSGSAVEGADSHDAGTIEAVLDRAAPRVFGLFPRAGSEAVPGDNVEAVFNEPLNCEKPSTVRATVKIGTEVTVTEQVLDVLCQGNTIHLSISNAFSSAALSGKSVQVTLSDIYDAAGNKMSQPVSWTFTYAELADAVPVPVSLDGLRFNVPWNASFGNVESTAFVDFSATLASELATVLSVSETRVELTSLREVSGGAQTVGTLKFLIPADPVGPAANDGLSAEQLASLFLSALYIDDTPPSLVNGGILEALDLDYQPSQSLAVARRAAAGANMEAGLPVASSTADSNDSEGNSADLYQILTLGVCISQFAVLAVMLVRRSRRRASEGVAGPAAETK
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MLNPSSNGESSHVVVNYVEEYLELVESLPLDLQRCVSLMKEIDAKYQEILNELDEAYEKHRQESDPVQRRRLLHCIQRSLIRTEELGDEKIQIAGQMVEMVENRSRQLEWHGELFQASHDSPESSVSVGSTPSAITTTAMTTISDILLSASKLTANRRREETPSSVDKSGGKRSRRQKNGSENRENSNYSLEHIEDVSSGTPKEKKPKASATSSKKKKRSKSKQDREPSPTDLPIDPNEPTYCLCEQVSYGEMIGCDNDECTIEWFHFSCVDLHHKPKGKWYCPKCRGDNEKTMDKALERSKKERAYNR
The following text describes a protein:
Function:
Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role (via N-terminus) in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. Further stabilizes spliceosome conformation for 3'-splice site docking (via C-terminus) promoting exon ligation.
Subcellular Localization:
Nucleus.
Sequence:
MSERKAINKYYPPDYDPEQAERQVRQLSKKLKTMHRDTVGIRLMTPFSMRCLKCSEYIPKFRKFNGKKELLPERYLDTIKIYRLSIRCPRCNSTISFRTDPNRGDYTMEAGGERNYVRDDARSPHIKPDETTDETLQRLLREEAEAARPADSAGEDRMQELEKRLARLQQEQHDAEEIDRLHRESLERGRRAASLAASIADRRTRAEADAARAEEAFRAAPAHVRPTTAPDPTPAAPAPARKPAGKNPLGVVVRNKKKQRARLAAQHRVPTDSAPADPSA
The following text describes a protein:
Function:
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
Sequence:
MATPGFPSTEQRLGLYPVVDSLLWIERLLAAGVTTLQLRIKNADDAQVEQDIVAAIELGKRYQARLFINDYWQLAVKHGAYGVHLGQEDLEAADLAAIQQAGLRLGISTHDEHELAVAKTLRPSYIALGHIFPTQTKQMPSSPQGLASLSRQVKNTPDYPTVAIGGISIERVPHVLATGVGSVAVVSAITLASDWQRATAQLLHLIEGKELADEK
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Miscellaneous:
MISCELLANEOUS: Present with 2850 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGDNYSTYLLDIEGTVCPISFVKETLFPYFTNKVPQLVQQDTRDSPVSNILSQFHIDNKEQLQAHILELVAKDVKDPILKQLQGYVWAHGYESGQIKAPVYADAIDFIKRKKRVFIYSSGSVKAQKLLFGYVQDPNAPAHDSLDLNSYIDGYFDINTSGKKTETQSYANILRDIGAKASEVLFLSDNPLELDAAAGVGIATGLASRPGNAPVPDGQKYQVYKNFETL
The following text describes a protein:
Function:
Putative oxidoreductase.
Sequence:
NNLNDLILLLTSLIGSFFILLISPILYFYQVKDNKQFKDPKTIVITGASSGLGSSLAIEYSIKSRGIKLGLVGRNKERLEKVKDECVKNGAQVEMALIDITDKEKLERWLLDFNERNPIDIVYANAAVTELTLNKDLNFSDRIYKTIDTNVYGILNTVLPILPSFQEKRNGQVVIVSSLATNTNFVYAGYTGSKGFATSFALTLRNRMSMCGVGVSVVCCGYIETPMSEPLQEELVFSVKPEEAAKITIRGVEANQAYIGFSRRMLIMTQLIHLIPGNLKDTFNNFLNKSWPFHDYN
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MSRVSMFPTEDKRSYFERQRDQYIKNISASMEDVLNNLNALNRSLEHTVGLSQKSEELAEMWSHFYNTVNEDLVKTEDGDIEVDTTKE
The following text describes a protein:
Function:
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MTSDVTVGPAPGQYQLSHLRLLEAEAIHVIREVAAEFERPVLLFSGGKDSIVMLHLALKAFRPGRLPFPVMHVDTGHNFDEVIATRDELVAAAGVRLVVASVQDDIDAGRVVETIPSRNPIQTVTLLRAIRENQFDAAFGGARRDEEKARAKERVFSFRDEFGQWDPKAQRPELWNLYNGRHHKGEHIRVFPLSNWTEFDIWSYIGAEQVRLPSIYFAHRRKVFQRDGMLLAVHRHMQPRADEPVFEATVRFRTVGDVTCTGCVESSASTVAEVIAETAVARLTERGATRADDRISEAGMEDRKRQGYF
The following text describes a protein:
Function:
Necrotrophic effector that plays a critical role during fungal penetration, via its interaction with the host Snn1 protein. Snn1 is a member of the wall-associated kinase class of receptors, which are known to drive pathways for biotrophic pathogen resistance. Recognition of Tox1 by Snn1 induces mitogen-activated protein kinase genes such as MAPK3 and activates programmed cell death, which allows this necrotroph to gain nutrients and sporulate. Recognition of Tox1 by Snn1 also induces other plant defense responses, including oxidative burst and pathogenesis related (PR) gene expression. The development of necrosis and disease induced by Tox1, and particularly penetration during infection, requires light, which is probably related to the light-dependent expression of host Snn1. Tox1 plays an additional role in providing significant protection from wheat chitinases by binding chitin in the fungal cell wall.
Miscellaneous:
MISCELLANEOUS: The host Snn1 gene confers susceptibility to strains of the necrotrophic pathogen Parastagonospora nodorum that produce the Tox1 protein.
Subcellular Localization:
Secreted. Note=Localizes to the outside of mycelium and the penetration structure. Remains largely on the leaf surface during mesophyll necrosis.
Sequence:
MKLTMVLSVAFATLTFANEGILTFEGLGLARRQTICHTPGGSGCRASISGDQCCCTSCTPEDCSDLCKNGKQAAHEAQKQKKCAKCCNAGGESHELCCSIASAGIDCNPCTAGLRMC
The following text describes a protein:
Function:
Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MAKIKKRGESGAAKNYVTRNQALKKLQISLSDFRRLCILKGIYPREPLNKKRANKGSSAPASFYYHKDIQYLLHEPLLVKFREHKAFAKKLARAIGRQEWGLAKNLEDAKPVARLDHLVRERYPTFTLALQDLQDPLNLVHLFSTLPTNPIPGKTLVPSEVIAECSRLISEWKLWAIRTHSLRKMFLGIKGVYYECEVPGQGGEPVRVRWLEGFEFQQHVPHDVDFRILLTFLDLYRTMVGFVLFKLYTDENLVYPPPLDVELDEQGESVGAFKLVERKAAEGADGKTQVSKKAVRKAIKGIKAAGDDADVDMDEGAKETDEEEDEDFVERPSKAQEVDDVASAPLTTYNSLLATSSTPARQNLLFSPYTFYLSRETSSRTWEFVVRAMGGKVITSLTAPTPADAPNADSITHVIIDRPITVERMREMEAGRKWVWIQPQWVADCVNKQKIISSEGYGPGQLLPPHLSPWDGEGELYRPWLEEQGEKAAEGQEGEEEEEAAEQDEGESEDEEEDGKEEVAAEYPPALLAAAQNPSDASLLHAAELEAETNGVSHSAFRAQLKEATKVHAKKVPASQKEKKGEEDLRKIMMSNKKAKLYEKMQYSNREKAAEKEKLEKKRKAIEKRKAKEAKA
The following text describes a protein:
Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Sequence:
MAKVNITRDLIRRQIKERGALSFERRYHVTDPFIRRLGLEAELQGHSGCVNCLEWNEKGDLLASGSDDQHTIVWDPLHHKKLLSMHTGHTANIFSVKFLPHAGDRILITGAADSKVHVHDLTVKETIHMFGDHTNRVKRIATAPMWPNTFWSAAEDGLIRQYDLRENSKHSEVLIDLTEYCGQLVEAKCLTVNPQDNNCLAVGASGPFVRLYDIRMIHNHRKSMKQSPSAGVHTFCDRQKPLPDGAAQYYVAGHLPVKLPDYNNRLRVLVATYVTFSPNGTELLVNMGGEQVYLFDLTYKQRPYTFLLPRKCHSSGEVQNGKMSTNGVSNGVSNGLHLHSNGFRLPESRGHISPQVELPPYLERVKQQANEAFACQQWTQAIQLYSKAVQRAPHNAMLYGNRAAAYMKRKWDGDHYDALRDCLKAISLNPCHLKAHFRLARCLFELKYVAEALECLDDFKGKFPEQAHSSACDALGRDITAALFSKNDGEEKKGAGGGGGGGPVRLRSTSRKDSISEDEMVLRERSYDYQFRYCGHCNTTTDIKEANFFGSNAQYIVSGSDDGSFFIWEKETTNLVRVLQGDESIVNCLQPHPSYCFLATSGIDPVVRLWNPRPESEDLTGRVVEDMEGASQANQRRMNADPLEVVFPHHWSHGHLHIHRSHSGLRWPLLCLEDTSDTVPAPEQGPDPTSAHPTYLLLSHCTFTTDPGLSSKLDAGSPLISALVPQQEDNMAFGKPAKYWKLDPAQVYASGPNAWDTGVHDASEEYKHRMHNLCCDNCHSHVALALNLMRYNNSTNWNMVTLCFFCLLYGKYVSVGAFVKTWLPFVLLLGIILTISLVFNLR
The following text describes a protein:
Function:
May only reduce GSH-thiol disulfides, but not protein disulfides.
Subcellular Localization:
Cytoplasm.
Sequence:
MPPRSLTLSRLPVAALGLPFSSCSPPPPRLRFPFAARRARSLATRASSSSPDSSFGSRMEDSVKRTLADNPVVIYSKSWCSYSMEVKALFKRIGVQPHVIELDQLGAQGPQLQKVLERLTGQSTVPNVFIGGKHIGGCTDTVKLHRKGELATMLSELDIDVNNS