lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.
Sequence:
MENGEELVGPPQLSLQWHQHHNTLVSLLDALWERQELVDVTLAADGQHINVHRIDVLTLKGNSDKQIIVFLKDVSYSDLKALVDYMYKGEVRINEDQLNSFLHTAKSLGIRGLMGDGKKVDIENDKKRKRRHSVELSSDQEEEEEDHSLTASSPPPPPPPLLKHKTSLTKPQNLEVKCELPMNQENRFESAMNTMQPETESLTQNSSINSGQELEDDELDLFQHCGVNNVNNHHNNHLHHPGPSRLSAEELHSSGQDLLVEHMAWGSVHNGSVDNHHLHHHDPDPGPGRHSCPRCGRTYKWKQTLLRHVKYECGVEPQFICPICRAPFHHRNVLQRHMNLHSRPK
The following text describes a protein:
Function:
May have a role in autophagic cell death.
Sequence:
MRLFAAATVALVLLLGQAAGEELAEERAGQAQGDAESTESSETTTDQAVSEPPITLVHVLNPGEREYLSPNLIGVQNIAMTFLPLSMNFVNIIDAFREITAGVRYEILLNALDTKAIQPAEADIVCRLVILEKPWLRTQWGDKHRELVTSNCTDPAVNSVAGDPAEKARLLNEKYVHRSRRSANDILGRHKPYDEEAAKAQLQKSLDKLTAGEGPHYKIVKVYSASRQVDSGILTRIDADLIDGSEEQHRCIVDIWTKVWVRKDEHEITFKCRNQPVVQARHTRSVEWAEKKTHKKHSHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANEMGSAKYGITEFADMTSSEYKERTGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTTDSACNGGLMDNAYKAIKDIGGLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANAMQFYRGGVSHPWKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSEMATSAVLA
The following text describes a protein:
Function:
Photorespiratory enzyme that dephosphorylates the 2-phosphoglycolate produced by the RuBisCO oxygenation reaction.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MSVKITTKEQAQKFLDQYDDFLFDCDGVLWQGNHLLPHVPETLQLLRDNGKRLIFVTNNSTKSRQAYTKKFEKFGIKVNKEEIFGSAYSAAVYLQKVVKFPKDKKVLVVGETGLEEELTEAGIPWLGATDAAYNRVADDEALSSIVRDKSIGAVLCGLDFHINYYKIANALIQLQDPETLFLATNIDSTYPSHGKLLPGAGTIVGTLETSSGRKPVALGKPSQAMMDCIKAQFEFDPSKACMVGDRLNTDMRFGEEGGLGTLFVLSGVDTEESIKKEDAVAKPKYYADKLGDLYELLKN
The following text describes a protein:
Function:
Forms the simplified baseplate, together with the p132 collar protein ring and the cone (DTP-pb9 and BHP-pb3).
Subcellular Localization:
Virion. Note=Component of the tail. Located between the first TTP-pb6 trimer and the DTP-pb9 hexamer, and surrounded by the p132 collar protein dodecamer.
Sequence:
MFYSLMRESKIVIEYDGRGYHFDALSNYDASTSFQEFKTLRRTIHNRTNYADSIINAQDPSSISLAINFSTTLIESNFFDWMGFTREGNSLFLPRNTPNIEPIMFNMYIINHNNSCIYFENCYVSTVDFSLDKSIPILNVGIESGKFSEVSTFRDGYTITQGEVLPYSAPAVYTNSSPLPALISASMSFQQQCSWREDRNIFDINKIYTNKRAYVNEMNASATLAFYYVKRLVGDKFLNLDPETRTPLIIKNKYVSITFPLARISKRLNFSDLYQVEYDVIPTADSDPVEINFFGERK
The following text describes a protein:
Function:
Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPSQDRTQTLVLDTAPLLTSSLSSLLLFSNRFVTTQDVIEEVRGKGQRERLEQEWKILDATLNNSAAQTGDEWTGLQIREPSTAGISKIKEFATKTGDIAVLSSADIRVLALAYDVEVEANGTWRLRDTLGAKRMGKDPEKKKARQLRKLQQQQQQQQDQSSGEKPAEESNSPTDHPVLCNGDPPKPTSAEVDSTSSQAGAEDVEQLVEHIDQLTLETAVNHPESSVSGAEEESDERREAPNHPVTSHSEITRADSVETASDIDWVKVPIKIGAKASEEESDISSFVSASDPSWITPENVHIHQAKDMGFFPSLGNKPVAPKLETIQQHSASLADQEHQHNNDQHSDINTPITNSTVGEGSSKPPTMKAAVLTGDYAMQNVALQIGLNVLGVGGKRIRDVKTWVLRCYGCFKLCKDPTRKFCPTCGGATLTRVSITYTPSSPTGYILHLNPNFQYRNRGTVYSIPSAKPGSSSFEKGGAKQKKSINGAHLVLREDQKEFQRGLKSVKIQKEKEERKLKNIEGSHSHALTSLSGWNDPDWEPAMLLGEKGRKSSGRGNHHNHSVRYGKDGLPLIGFGKNPNEVRRCSKR
The following text describes a protein:
Function:
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
Sequence:
MSASLVRATVRAVSKRKLQPTRAALTLTPSAVNKIKQLLKDKPEHVGVKVGVRTRGCNGLSYTLEYTKTKGDSDEEVIQDGVRVFIEKKAQLTLLGTEMDYVEDKLSSSRKARGSLVAHCRNRVTHMLENKVIHLENEASVLDSRRNDICILYRGQKVRSHHSLWII
The following text describes a protein:
Function:
May be involved in inflammatory process. May regulate cell architecture and adhesion.
Subcellular Localization:
Nucleus.
Sequence:
MWCLERLRLGPECLRRSGDWLLPGRARGAKSRTTAACANVLTPDRIPEFCIPPRLMPRLALAALRNSWVEEAGMDEGAGRTDWDPRSQAALSLPHLPRVRTAYGFCALLESPHTRRKESLLLGGPPAPRPRAHTYGGGGGPDALLGTLRVPRAPGPATPAAPGCPRPPQDALARRPRGCRLLRVPDGLLSRALRAGRSRRLTRVRSVSSGNEDKERRAGSQSPARAPSTSPPSSRVPFPERLEAEGTVALGRAGDALRLAAEYCPGTGRLRLRLLRAESPAGGAPGPRAVSCRLSLVLRPPGTALRQCSTVVGRSRKASFDQDFCFDGLSEDEVRRLAVRVKARDEGRGRERGRLLGQGELSLGALLLL
The following text describes a protein:
Function:
Involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharides (MGLPs). Catalyzes the dephosphorylation of glucosyl-3-phosphoglycerate (GPG) to glucosylglycerate (GG). GPG is the preferred substrate, but GpgP also exhibits low dephosphorylation activity on mannosyl-3-phosphoglycerate (MPG) and mannosylglucosyl-3-phosphoglycerate (MGPG) in vitro. Shows only trace of phosphoglycerate mutase (PGM) activity.
Sequence:
MRARRLVMLRHGQTDYNVGSRMQGQLDTELSELGRTQAVAAAEVLGKRQPLLIVSSDLRRAYDTAVKLGERTGLVVRVDTRLRETHLGDWQGLTHAQIDADAPGARLAWREDATWAPHGGESRVDVAARSRPLVAELVASEPEWGGADEPDRPVVLVAHGGLIAALSAALLKLPVANWPALGGMGNASWTQLSGHWAPGSDFESIRWRLDVWNASAQVSSDVL
The following text describes a protein:
Function:
Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (By similarity). Has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MNIELINTNERFILINNGNKDKSLNIDKHSVKASISVGVPKNNEKVLTRIENVKGIIGCIQLVSGHYLMIFKEHNHVATVTGKKIYQMKDVELIPFFPNQQSLVSIPDQDAEEQHLSMIRWLLSSENFYFSYDYDFTLTLQRQYSTTTTTTSGSSLGERCDSRFFWNEKYVTILSKEHGLGDWILPITMGFVESKTLGGTCQFTLISRRNLNRSGTRYNVRGIDKKGNVANNVETEQIIEIKENTFTSFVQVRGSIPLLWSQFPTLKYKPSVKFYGDEKENSQALEQHFKQLHQLYGSTTVVNLIDRKGAELKLGEAYEERVKSLKDVHYVWFDFHSICKGMRYDKLSILMDQLKDDLKQYGFFFVEDGKIVQKQQGVFRTNCIDNLDRTNVVQSLITRHSLENQMASVLNKQIPSTTFKGDQFEYVFKNIWADHGDAISTQYSGTGALKNDFTRTGKRNFQGVLRDGENSVKRYYLNNFKDGFRQDSYFLFTNPSVDLTTAKQHESKPPSPLIWIFSFVFAAIFLANLYLPSATSSIGGFISQTTVLVGSVFFALKLAMKYQASIVDKPTLFKLDSIYKN
The following text describes a protein:
Function:
Part of prostatein which is the major secretory glycoprotein of ventral prostate gland. Steroid-binding protein; can bind non-polar steroids, cholesterol and a group of small proline-rich peptides (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MKLVFLFLLVTIPICCYASGSGCSILDEVIRGTINSTVTLHDYMKLVKPYVHDHFTANAVKQFKQCFLDQTNKTVENVGVMTEAIFNSESCQQPS
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Subcellular Localization:
Nucleus.
Sequence:
MIVDALTWPSRSKMSSCEDDVVAIRKKLEKMIEGSKPQDDAAELVEALARLPINYTVLNNTRVGLVMNDLRKKTSNEKLSKRIKQLIKDWKTIVETHNSGNGNGGGSGEKAEKTAPVARTESSSSSTMKEAGDSQPTPTPRPKLAPTVAQFSGAFPPKSIEGDDIRVKSAQMLLSALKMGEMPDGTLDPEQLAVHRGTSDKYKAALRSRVFNLRDKKNVALRENVLTGVVSTDKFAVMLPEEMASDEIKKMRETHAVGHCGKCGKKNCTYTQLQTRSADEPMTTFVFCMECGNRWKFC
The following text describes a protein:
Function:
Participates in transcription termination.
Subcellular Localization:
Cytoplasm.
Sequence:
MTQSIKLTTDQMRMMSLFQNVTGATARDCVEDEKQDRVIFVVNTGKMGLAIGKGGMHIKSLQNIVKRNVELVEFDEDPAKFLSNLLNSKLVSEVKINTRADGTKQAIVMVDPRKKGIVVGREGRNAEKARMLAKRYFDITSVLINSPERQTLEM
The following text describes a protein:
Function:
Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAEVPPGPSSLLPPPAPPASAAAEPRCPFPAGAALACCSEDEEDDEEHEGGGRSPAGSEATAATKGRPCLRCPQPPQEQLQLNGLINPELRHLRAATSLKTKVLSAAEAATITATPDGGPRVTATKGAGVHSGEGPPHCLPNNARTALPSPAEAAAAASDPAAARNGLAEGTEQEEEEDEQVRLLSSSLTAGCSIRSPSGREVEPGEDRTIRYVRYESELQMPDIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLAMVGEECVGAIVCKLDMHKKMFRRGYIAMLAVDSKYRRNGIGTNLVKKAIYAMVEGDCDEVVLETEITNKSALKLYENLGFVRDKRLFRYYLNGVDALRLKLWLR
The following text describes a protein:
Function:
Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) by incorporating an acyl moiety at the 2 position. This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MIRYNNNKKTIEGDRMFYTYLRGLVVLLLWSINGNAHYHNTDKIPNQDENYILVAPHRTWWDPVYMAFATKPKQFIFMAKKELFTNRIFGWWIRMCGAFPIDRENPSASAIKYPINVLKKSDRSLIMFPSGSRHSNDVKGGAALIAKMAKVRIMPVTYTGPMTLKGLISRERVDMNFGNPIDISDIKKMNDEGIETVANRIQTEFQRLDEETKQWHNDKKPNPLWWFIRIPALILAIILAILTIIFSFIASFIWNPDKKREELA
The following text describes a protein:
Function:
Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate.
Sequence:
MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKERYHEVELCDRDVIEIVHFVGGG
The following text describes a protein:
Function:
Plays a continuous role in plant development probably in the structural organization of compartments.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MTIALTIGGNGFSGLPGSSFSSSSSSFRLKNSRRKNTKMLNRSKVVCSSSSSVMDPYKTLKIRPDSSEYEVKKAFRQLAKKYHPDVCRGSNCGVQFQTINEAYDIVLKQIKNQMEGTEEFEPFDVYDEGLNGMNDPDCDTWEEWMGWEGAGTRDYSSHVNPYA
The following text describes a protein:
Function:
Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAGPLWRAAVFIQRHRTSLLVGSCVGLFGVQISFHLFPDPIVQWLYQYWPQGQPAPLSPQLRSLFQEVLKDIGVPSGHCYKPFTAFTFQPVSAGFPQLPAGAVVGIPAIFLGGLVTNIDHTVVIHGQKVDWQSPAGTRLRDALTLSHDAQKFALAKEVVYLESGMAALQTLPAPVCLAGTWAISVGAKHALGLYGGPMSLRAAFNLVAIVVGYVAYAFSKDSLTVALEGWLDHRTASLSAAYVRGGVEFYEKILSGNLALRSLLGRQGEKLYTPSGNIVPRHWFRINHLPYTTRRDSLLQMWRAKVSPGHF
The following text describes a protein:
Function:
Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative DNA synthesis in bacteria.
Miscellaneous:
MISCELLANEOUS: Unlike E.coli this gene does not also produce the shortened gamma protein; there is no defined order for DNA clamp loading complex assembly.
Subcellular Localization:
Cytoplasm, nucleoid. Note=Localizes in tight foci to the chromosomal replication center at mid-cell; positioning does not rely on the C-terminus of SSB (ssbA).
Sequence:
MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFSGPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVDEIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPHKIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDALSLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGKDPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILNKSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTGIKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQQNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKRMDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD
The following text describes a protein:
Function:
Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.
Sequence:
MTKYAFTVELCVNSGDPLAFKMDGHRFDGALRTLKWSTDQTYAVKITTKPATEVTRINVNGADLDITKEKLGVFSGNWNTTGSEISKRGTRFPLIFLVDFAPEGQMRVEFQSKIYSKNDSHAVWGHKMNAVEFKCCGDDDGYVKIVDESYK
The following text describes a protein:
Function:
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.
Subcellular Localization:
Nucleus.
Sequence:
MDGPEGKEMEGTEGKEMEGTEGKEMDGTEGKEMEPEVDNKTIKVEPTEPGETHLRENSPDPDHGHDTDPDPDPGEGPSSLIRDPKLGLCEPKPGPSRKIIDDDDDDDSDDEDEDDEDEDEDEDDSHLPLVVWEQPLKVGKEEPMDYDDDCMPGPSRAKPLHNWDSDSDSDSDSSTTSCRIRELPVQDEEEEDDQAQAQAQAPAPKQKSIFCFKKKDIPAIDTPLPIDDMTLILPESVELQPFGRVSGIIEKLVIIESVTDLPPVCEDSMIFKSNRHAAGKIFEIFGPVAHPFYVLRFSCMEHIKRKDIKIRDIMYFAPSIQHFTRYIFTDRIRDRGSDASWKNDLEPPPEAVDFSDDEKEKAAKSKKKYYGRNRKKQRAEYRSKSRSSYSRDRKGYRPESRQLALEDDREEEVQEEAKVEEVQEEAKVEEVVEEAKVEEAKVEEVQEEAKVEEAKVEEVQEEAKVEEAKVEEAKQEDREEAKQEPKQENRQGSRQESRQGSRQDRQASRSQDNRQGARERSVSQQENRQSTHRDQRKGGRQDQRKGGRHDHRHSSRHDRRQDRRQLVQHDHRQLMQQDFRQEYCQEFGQEFGQEFGQGFGQGFGQGFGQGFGQEYGQEFGQEFGGQDYGQLEFGQLEFGQQEYAQEYAQEYQEFRQEYQEYHQEYRPAAAAAAAAAAAAAAAAAAEYHQEYRPVAEYRPDYQNLGAYGGEAPAHWCPQPREAGRGCYSKREYHREFSRARHHKASHTRTQAAAAQFYADHRGNQDAPPSLFAPHHRY
The following text describes a protein:
Function:
Nuclear envelope protein which has essential roles in assembly of nuclear pore complexes and in chromatin maintenance during the cell cycle. Appears to be a stable structural component of the nuclear envelope during interphase. In dividing cells, localizes to kinetochores during early stages of mitosis and then to chromatin during late mitosis. Important for several mitotic processes including chromosome condensation, kinetochore assembly, chromosome segregation and cell-cycle timing. In postmitotic cells, plays a role in the early steps of nuclear pore complex assembly by recruiting the nucleoporins npp-10 and npp-5 to chromatin. Also involved in meiotic chromosome segregation. May function downstream of the Ran GTPase signaling pathway.
Subcellular Localization:
Nucleus. Nucleus, nucleoplasm. Nucleus envelope. Nucleus inner membrane. Nucleus, nuclear pore complex. Chromosome. Chromosome, centromere, kinetochore. Note=Has a dynamic expression pattern during the cell cycle. During interphase, localizes to nuclear pore complexes and is also found in the nucleoplasm. During early mitosis, localizes to kinetochores in a hcp-3/CENP-A and hcp-4/CENP-C dependent manner. At later stages of mitosis (anaphase), widely distributed on chromatin. During telophase, localizes again to the reforming nuclear envelope.
Sequence:
MDNENSSIFKSYQGYECWRGEKQIILKDSIGRQLPYIVNFKKNTCQIFDIEWERVTHSFVFPEGCALIDADYFPTEEGKLGILVGVEDPRQSCGAEHFVLALAVDPDSPAMTITHSLEVPSKITVVKTLFSSADMADETQRTVLKLYHRLMTWQHIVAIGCKETQCYLARLVAVETPSSPVITVHSEKKYLINLMNAYVSGSVLQYTLDDGAYREYPTAAVYISALSLMPRSRTLLVGLSMGGILAASLNPSNQMMLLELRHERLVRKIAPLEPEDDPDKFEYFIATVDCSPRHPIMIQLWRGSFKTLEDVDGEEKYDRPSFSVCLEHKILFGERWLAVNPIVTERDHMMLTRKRGTEDSMHNVSQTFGSTSNRNSVLLAYERKKMVIGTEDPNAEPEYIVEAAIFDIDSWYYKRVPGRVSTDGTVLKQCAFLSTIKSNIRSEDVNDIGILTNEATDVSSFSSMVSDADQLFYPSALSFERVFVAKNTRIDWMKIQNIQDTILNKCAVKLPALIRNPEMISSVVMAAGLVRKNILSGSPNSSAAEINELQLSSDQKVLLNVIVYYGKIEEFCQLASRPDISDTLKRELAEWALHEAVDYKRTISDKMVSLFQGRSLALSPLAEESIAQGIKLFRVVYEYLKACSKALKDDRLRNLAHSVICMRNHTKLTSQFINFAIIPVDPIRQQRMKDLHSKRKNMARKNSSSLPVQSVVRKMNRQAPNAQFWNDIPHDEWYPPTPLDLLECLLNVSISESIKRELVVQYVIDWISTSPEDSEHSEKQLALETIKIMTNQMLNVNLEKIYYILDQGKKALTSSKTSDDMRALGEKVFSMKDDEISYEKLWGKDAPMTVTIGKHDLQRFEQRMKMQMEGGKVRLPVLDPESEILYQMFLFENEKFEAMSSEAISSNKLLSAFLPGMIKKDGRGRQKTAKEQEIEISVKKMFERKVQNDDEDMPEVFASVNDKTERKRKSSQFGEDDESSVSSSQYVPPTAKRIQQWKSAVESVANNSSINSITSPDSHQNAEINMMIATPARYYKRHNEEENVQDGFLSPAGNRPPPVSAHNSILKTAKGGQSASRGRIRFRADVPRGADESIEDNGRKGLALNFAILEDEEEETMTIRKSRSMGKHDEEKDSEKNVVDEMEEVKDQEQENDECIESEKTFENQDDFEVLEDTSAPEAANTENGSETPPMEDTFEVRDDDVMPPTDETYLSHLQTDKTGILEEEGEDEDIWDGVQRSFEVQMDEDCEAVPTIDVADDLESKSEEVNEEEVVESEEVQQDAKEPEKTEKRQEEPEPEVMQPVIPEEPQNESLESSIKLQEELQEEPDIVPTGDEDTADKVQEQAVEEDRPPSRNTRSSSVQKSTSQVEDRDPKELVEEERPPSRNTRSASVQKSSNQEKTSESGEVTEEDRPPSRNTRSASVQKSSSKVKDQKPEELIEEDRPPSRNTRSASAQKTVAANKSVLESEIPSRSASRRTRSTSLRNDTVAEPDETSVAMTTRRRTRATSEVVSKQSSEDDGRSTPKTGRTPTKKAAASTSSSRAGSVTRGKKSIIQKMPSPLEVTMEVQEEEEEEAEEERPASRSTRSASVKNTTVDPSSSALASTKRTTSRKRGNSETIDFNQDDKSAPTTPKRGRPAKKDAGSPKVGSKARGTKPKSIFENQEDEEDRSSSPDIEQPATPTRSSKRTARSRANSESIDDDSKQKTPKKKNAAVNEAGTSKQSRSVTRSRASSIDVQQEVEEPTTPKRGRGRPPKTVLENIEEGEEERKETAATPLLRSARRAKQ
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MEVDLPMETDGLSPCDRIVLRLVQFGLPKSYAEKLQPGLVAYAKMSNAQLSKLVHTILPTNEVILEACLVTGLEEARRALNLQKVKDEFRESILWLQWLMFGNSPHTVLENLAKSSTGQHGVCGAVWGNQDIAYRCRTCEHDPTCAICVPCFQNGDHRGHDYSMIHTNGGCCDCGDETAWKRQGFCSKHKGPEQVRPLPEKIANSVDPILEELLVCWKNRLSDAETIAHKSPRDGNQNPILTIANVMSCVVIEMLSEFCQCSESLLSFIAKRMFSSSINLLDVLVRTDRFLIKKIVKKLHALLLKLLGDPNFKYEFAKVFIKNYPSIMSEAIRECREQREGILMDNGSEKYPLLSNFSVQIFTVPTLTPRLVREVDLLDVLLGSLEEFFASCIVEDGHLQVGRFSGLYDLCFRLVEDIRFVMSHTEVTKFVALERRDISETWIGLLATMQGMDPQKRVTGIHVEEENDSWSSSFLLEHVMANIHPLFVTGAFSLGDDKELKDHRLFDKCLLELDDGNLRHAKIGRLSEENSVRSMTGRSNLWHNSQEINQVSVSECCDSIPSSVTWLILICMRAIENWLAHDPARGLQGTSDNLLRRWKSKSKTKKNRGCITGMAGESTPQLDKELAISSVFSLLEWPEIIYDVSSQQISFHIPLHRFLSLLLNKALETYCDSSGMAHTTAASSQSPLPGGSHEFLRKILGRCHPCGFSAFMMENPLRLRVFCAQLQAGMWRRNGHVAISLYELYHSVRWCEQSLELDLFLLQCCAALAPPENFVRRIQERFRLSDYLSLNLNRSNEYEPVLVKEMLILIIQIVKERRFCGLSSAEILKRELIYRLAIGDATHSQLLKALPHDLSNDDRLQEIFDTIATYMNPSGMQQGKYSLRKECWKELDLYHPRWNSRDLQVAEERYARFCGVSAMAVQLPRWSKVFHPLRNISWIATSKAVLEIIRAVFYYAAFSESSSASRAPDAVLLTALHLLSLGIDICLMLKQGNTSNCNGNNDLSITPDQEYAGTPCNGEDPSFPLLSHACEEVEVGATHEPEVSNHQSLLSLSVLLIKKYTKENESGVLESNHCNIPSLMRSLLKKLAELDAGCMNELKHLAPEIVCHLSERSHNSSDLVASDSERRKAMVRERQAAILEKMRAAQSKFMASLNTMPDDGSELSRSKPEEFMFNDTRNSEEPNAVFCSLCRDSESRSPLSFLVLLQKSRLLSLLEKGPPSWDQIYHKDKDEAAYTRGPGEITHADLVELIRNAVNVVSHGRQTAEVDDFLDNVRVQLPSETQSAHPSESYGSNENVSSSSVMMEHDTPNSSQQSNSYMPSSSSNNDEENSPISHSMDGSVTSRDADDDVLREYAESLPGELSEQQLAAENGFLPHRSASSVPDCQSLSFDGFGPVDCDGIHISSCGHAVHQECRDRYLQSLRQRYISRIIFEGVHIVDPDQGEFLCPVCRRLANSVLPVVPDGYPSNKIQKHMLFSKNFSSKSAHSSVSVSHGLRLRQALSLLQGAEDRVGRSGSRGVISARIDEQMKPALESVFHALSKMYFSERSNTLSASGRVCSSLLLWDVLRYSLMSTEIAARHGKPNMPIRSSQASLEALYKEANSSMGFILGLLLQVCQATQIQSRSLVLMRYRGIRLFLGSICSGSSLDESYKDTQRGDLSSLLKNFDKGKLCPDIRFWKRAADPVLVHDPFSSLMWVLFCLPLAFPLSEESFISLVHLFYVVCMIQAVITCCKKRVFDISELNSGGRLVTSIYKKLGEALINEQHFGSNYFDGSCPPVTMIRRYTLPYLRRCALLLKLLKSSMSAPFHGTSHVWERSSSHMSIDEMKSIDRISLELEEVLELENMFQISPLEDVLEGEEVQTLAMKWCEHFFKSSGVRSYGHVMLSTPAIPFQLMCLPPIYQDLLQRYIKQQCGECKINSDHPSVPALCLLCGRLCNLNRRSCCRLCDCQSHATACGAGIGVFLLIRKTTILLQRSARQAPWPSPYLDAFGEEDIDMQRGKPLYLNEERYAALNHLVVSHGLDQSSEVLRHTTIETLFAF
The following text describes a protein:
Function:
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
Subcellular Localization:
Cytoplasm. Membrane; Single-pass membrane protein. Mitochondrion. Nucleus, nucleoplasm.
Sequence:
MFGLQRNAVIGLNLYCGGAGLGPGSGSSASAPGGRLLATGKEATARQEVGGGEAGMVIGGSAGASPPSTPAPDARRVARPSPIGAEGPDVTATPARLLFFAPTRLASPPEEMESPASDAIMSPEEELDGYEPEPLGKRPAVLPLLGLVEEASSGPGTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDAKPMGGSGAASRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMVHVFSDGVTNWGRIVTLISFGAFVAKHLKSINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
The following text describes a protein:
Function:
[Protein 1A]: Suppressor of RNA-mediated gene silencing, an antiviral defense mechanism of insect cells. Inhibits siRNA function through the direct enzymatic inactivation of host AGO2, but does not interfere with miRNA pathway. Facilitates viral replication via the recruitment of a cellular ubiquitin ligase complex that promotes host AGO2 degradation. Inhibits the integrated stress response (ISR) in the infected cell possiby by degrading host Nup358. Stress granule formation is thus inhibited, which allows protein synthesis and viral replication. Does not bind to dsRNA or siRNA; [RNA-directed RNA polymerase 3D-POL]: Replicates the genomic and antigenomic RNA.
Subcellular Localization:
Host cytoplasm, host perinuclear region.
Domain:
The BC-box mediates viral E3 ligase assembly in order to degrade host AGO2.
Sequence:
MSFQQTNNNATNNINSLEELAAQELIAAQFEGNLDGFFCTFYVQSKPQLLDLESECYCMDDFDCGCDRIKREEELRKLIFLTSDVYGYNFEEWKGLVWKFVQNYCPEHRYGSTFGNGLLIVSPRFFMDHLDWFQQWKLVSSNDECRAFLRKRTQLLMSGDVESNPGPVQSRPVYACDNDPRAIRLEKALQRRDEKISTLIKKLRQEIKNNRIYTQGFFDDLKGAKGEVGQLNGNLTRICDFLENSLPTLTAQIQTTVLTTTDKYVNLKEDLLKVAILLVLVRLLMVWKKYRAALIVIILFVMHFYGFDKQILDIVLDLKDKILQTTTQAGTETLEEVVYHPWFDTCGKLIFAVLAFFAIKKIPGKQDWDNYISRLDRIPKAIEGSKKIVDYCSEYFNLSVDEVKKVVLGKELKGTQGLYDEIHVWAKEIRHYLDLDERNKITLDTETAAKVEDLYKRGLKYSEEKIPDRDIARFITTMLFPAKSLYEQVLLSPVKGGGPKMRPITVWLTGESGIGKTQMIYPLCIDILREMGIVKPDAYKHQAYARQVETEYWDGYNGQKIVIYDDAFQLKDDKTKPNPEIFEVIRTCNTFPQHLHMAALQDKNMYSQAEVLLYTTNQFQVQLESITFPDAFYNRMKTHAYRVQIKQEKSIWVRNARGEEYNALDVTKLNKDEAIDLSVYEFQKMRFDDESATKWIDDGEPISYDEFARTICKAWKEEKEKTFHQLQWLEAYASRTVAQGGSETSEYYDVWDETYFSNLLSQGFMAGKSLIEMEAEFASDAETFNAYIEYKKNIPKETKWSKWMTILDEQISALSTKIRELKNKAYKFISEHPYLTALGFIGVMISAFAMYSFFERTLTDDTITSEVGSSGDNKTQKISKRVVEVGGSGDVKTTKPAKTAVEVGSSGDSKTMKNKITKVEVGSSGDSKTQKQRNTKVEVGKELEKEAETQGCSDPAAHALVLDVLQKNTYCLYYERMVKGEMKRYRLATATFLRGWVCMMPYHFIETLYARKVAPSTNIYFSQPNCDDVIVVPVSHFIAPNAERVELTTACTRIHYKDETPRDCVLVNLHRRMCHPHRDILKHFVKKSDQGNLRGVFQGTLATFHQSANELCRAYQWLQAIRPLDQEITIYHEDTDMFDYESESYTQRDCYEYNAPTQTGNCGSIVGLYNKRMERKLIGMHIPGNVSECHGYACPLTQEAIMDGLNRLEKLDPVNNITVQCCFEPPSDIKDTMSGETPEGKFCAIGKSNIKVGQAVKTTLLKSCIYGMLSKPITKPAHLTRTRLPNGEIVDPLMKGLKKCGVDTAVLDAEIVESAALDVKQVVLTQYNSMLDVNKYRRFLTYEEATQGTGDDDFMKGIARQTSPGYRYFQMPRKLPGKQDWMGSGEQYDFTSQRAQELRRDVEELIDNCAKGIIKDVVFVDTLKDERRPIEKVDAGKTRVFSAGPQHFVVAFRKYFLPFAAYLMNNRIDNEIAVGTNVYSTDWERIAKRLKKHGNKVIAGDFGNFDGSLVAQFFGQSCGKSFYPWFKTFNDVNTEDGKRNLMICIGLWTHIVHSVHSYGDNVYMWTHSQPSGNPFTVIINCLYNSMIMRIVWILLARKLAPEMQSMKKFRENVSMISYGDDNCLNISDRVVEWFNQITISEQMKEIKHEYTDEGKTGDMVKFPSLSEIHFLKKRFVFSHQLQRTVAPLQKDVIYEMLNWTRNTIDPNEILMMNINTAFREIVYHGKSEYQKLRSGIEDLAMKGILPQQPQILTFKAYLWDATMLADEVYDF
The following text describes a protein:
Function:
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Can assemble a [2Fe-2S] cluster, but cannot transfer it to an apoferredoxin.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAVTAFNTLKLVSSSLDPIPSVSCSSYSFSLIYVGSPYKRCLKQSCSVRAMTSSSSAASSSSSSFGSRMEESIRKTVTENTVVIYSKTWCSYCTEVKTLFKRLGVQPLVVELDQLGPQGPQLQKVLERLTGQHTVPNVFVCGKHIGGCTDTVKLNRKGDLELMLAEANGKNGQS
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Sequence:
MARSLSWHCCPWCLTEDEKTALRIDQEINKILMEQKKRDRGELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDRKGFTSLVYQNIFTSMQAMIEAMDALHIPYGCPESRHHADLIMNTDAYKLTTFEKPQAVAIKWLWRDAGIRACYERRREFHLLDSAVYYLSNLERITEESYIPTAQDVLRSRMPTTGINEYCFSVQKTNLRIVDVGGQKSERKKWIHCFENVIALIYLASLSEYDQCLEENNQENRMKESLALFGTILELPWFKNTSVILFLNKTDILEEKIPTSHLASYFPSFPGPKQDAEAAKQFILDMYTGMYTGCGEAKGSTRKSSRSRRLFSHYTCATDTHNIRKVFKDVRDSVLARYLDEINLL
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPPSPDLRADEPKTPCLVGGAHAFILKISSFCGLAPLRFEPRSQEYAVTISKGKCFYSYILVTFLVICTIYGLVAEIGVGVEKSVRMSSRMSQVVSACDILVVAVTAGVGVYGAPARMRTMLSYMENIVAVDRELGRHHSAATERKLCALLLLILLSFTILLVDDFCFYAMQAGKTGRQWEIVTNYAGFYFLWYIVMVLELQFAFTALSLRARLKLFNEALNVTASQVCKPVKKPKNSQLSVYATSVRPVSCKRENVIVETIRVRDKDDAFVMMKTADGVPCLQVPPCEAVGRLSRMRCTLCEVTRHIADGYGLPLVIILMSTLLHLIVTPYFLIMEIIVSTHRLHFLVLQFLWCTTHLIRMLVVVEPCHYTIREGKRTEDILCRLMTLAPHGGVLSSRLEVLSRLLMLQNISYSPLGMCTLDRPLMVTVLGAVTTYLVILIQFQRYDS