lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MPRRSSRLSAALSAAAGPSTSTSTVQRMAVGITPPQQSARKATSTNETASCFRTARSPSHASEPNITPYYAKSLCDPSSPSLGDASSSYLAVQSFFTQLARPTIQQQAVSRITAASPASHAGVLTRLRHAIRPASSILQQARGFRAAQIPRADDKDQSRSDNAKTHAAPTDSATKHAKHPVSQATGSSHPHAEHSHDAVKAPSPSTELTKAERAYHHFANYPASLRRLAMRAVPTSSQNGQGQLSKANEVQPHELQRLRPSKEDLLRYAQGFWTRLRIRFKWFTIRGFRRFNADDISAFFTLGGFTTAVFIIVGTTTFFSLIFAALNALNLQEWIARKIADYLTAETGVTVVFESAIVPKWKESKISFKNVFISRRAHSDVDSLLEERRQKARDRNRDRPNKVKRRTALTAGDGMAWEGTHYDEVEEVAPPMSDEARGEDLAEDDTINTNYTMFDLQVDSIDVTLSLQRWFDGKGLVEDAVVRGVRGIVDRRNVFWDPNKPYDPKAARRAPRHGDFELESLVVEDFLVTVYQPNDFRPFNFSIFSAHIPKLRKQWLFYDLLSADSITGQVDGCLFSLHKPQNISRTVEQDREISNSKWKTMSRMRVDGVNFDHIQNQSDLTGPISWILSGKFDVVADIKFPRDLDDEADINTIIIEVLDNLTAALSGESNRDCDDDPIPGQHRLSGPAIEAPVSAVGATAERVRKENEEARRQGRDPSSAGVQRRAVADANATSDNSTESSSSSSLSPQLTQDGEKTKTSIPPPTVVIDMDVRFKDIKAAVPLFTNDISYRTNAFVRPIVAFMNANKTLIPIRCRIVMDLSEFDGSLDLAQTGLLPVVSEKIYEALANHVASQNASTKRLKNVSLWSLQVSANAALNLVTLLRNTMARTTGTNGAIATKHSN
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes; Regulates also the sphingolipid metabolism.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MNNTSNTSTQNENKNESIIDKKDSMKCIECGCDIDNTYEIFCGQFIRLLRCPKCGKVADKYIEYDNVLVFLDMLLQKRPVYRHLLFNHDESINGFFIKLFFGSLLLESYIRQMTTLTPSIYSFIWNGIQIVIEDIFFLAMFIIPFSFYKRISFKDSCNLVAQSYLIGSLGKVFLCLVLMWTNSLPIYLFSITMANLTFIACMSVVFEISTWKMLIIGFVIGIIYTIITSQFFPLTPLTYYIKNKRLLDLLIGDLYTF
The following text describes a protein:
Function:
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MENFWSIVVFFLLSILFILYNISTVCHYYMRISFYYFTILLHGMEVCVTMIPSWLNGKGADYVFHSFFYWCKWTGVHTTVYGYEKTQVEGPAVVICNHQSSLDILSMASIWPKNCVVMMKRILAYVPFFNLGAYFSNTIFIDRYNRERAMASVDYCASEMKNRNLKLWVFPEGTRNREGGFIPFKKGAFNIAVRAQIPIIPVVFSDYRDFYSKPGRYFKNDGEVVIRVLDAIPTKGLTLDDVSELSDMCRDVMLAAYKEVTLEAQQRNATRRGETKDGKKSE
The following text describes a protein:
Function:
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. Binds single-stranded DNA (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAGKRVIASGDKASSKKPKTEKQSDHELHWALNETEKKRITLSEFRGTRYVHIREYYEKDGDMLPGKKGIALNINEWKKLKQLIHEVDDSLGLVDSGSDSEDEIKEKAENNASLKNDEDDLNTKTENKTDDSSVEN
The following text describes a protein:
Function:
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
ALCSRGARGWIWSGVSQRSGEEPVRVGDGEADRRRGSGRMGDPMITTPPGLYYISLAYVASLFPGAWVTRIAEAFDALCTTALLRSTNVIMAMICGVLVHDLLLCIRPKIGKRKATAFAILVALYPIHWFFTFLYYTDVASLAAVLAMYLFCLKKQFWVSAAFGAFSILLRQTNVIWMIFFAANGAIAHAQYLYVKDNVCYENSELTDKSNKEASHMDNKTTAPGLRRRRNNNPINKREVVSESNIMYSSFTEEIWDAIFKLWNSKCEVLIAFIPFAMVLLVFVAFIVWNGGIVLGAKEAHVVSPHFAQFLYFGLVSAAALLPWHFTPTRASDLFHWCRKNKTYSSFAILVALGLSLVAVHLFSIAHPYLLADNRHYTFYIWRKVIQVHWMMKYILTPVYVYSWFSIVNILGKSQTRLWVLSFVLSVALALIPAPLVEFRYYTIPLVILVLHSPVISNVKLLALGFLYAAVDFFTLAMFLFRPFQWQHEPGTQRFIW
The following text describes a protein:
Function:
Maintains the proteasome and its anchor cut8 at the nucleus envelope and is required for kinetochore component proteostasis. Proper kinetochore stoichiometry ensures the correct attachment of kinetochores to spindle microtubules during cytokinesis. Required for the localization of spindle assembly checkpoint (SAC) protein mad2 and bub1 to the nucleus envelope during interphase, but not their localization during mitosis.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus envelope.
Sequence:
MSSGGLEDDIQLVHEFLDVSFEDIKPLVSVNGFAVFISAIKTKVKDINALKDQLVLQEVNHEHKENVLTKKINFLEQQLQSSNNQAEESRNLISVLRNENESLKTNLENQNKRFDALTTENQSLRRANSELQEQSKIASEQLSIAKDQIEALQNENSHLGEQVQSAHQALSDIEERKKQHMFASSSSRVKEEILVQEKSALVSDLASLQSDHSKVCEKLEVSSRQVQDLEKKLAGLAQQNTELNEKIQLFEQKRSNYSSDGNISKILETDPTSIKELEEEVETQKRLTALWESKSSELQSEVAALQEKLTSQQSLYNNVTEELNNNKQQLLISENSLRELQEKYDSVVSELQVVKENKNTSVSAGVGLFSPLAQKLSAVQNPEFSFTKVYSDNMKLQQKVSSLKLQLDRLTNKFSSFCEQVKQRIPVVKQQRSEIVRNNIYMNFLSESLETSNNNLTKVQAELLSTKMRQEACYLQLTASRTQCSDLSREVICLMAELDHLNETKSRNVPATVQVALDEYAQNPSTASETLVNKELANFSSIKEAVSKTLELREKVRALECDVEIQKQTVQYQISNAVKENSNTLSEQIKNLESELNSSKIKNESLLNERNLLKEMLATSRSSILSHNSSAGNIDDKMKSIDESTRELEKNYEVYRNEMTAIQESLSKRNQDLLSEMEAIRKELENSKYQQQLSTDRLTNANNDVEAFKKEAKELRSINQNLQDIISRQDQRASKFAEELLHVNSLAERLKGELNASKGEKDLRKRTQERLISENDKLLAERERLMSLVSDLQTFLNQQQLSDAARKVKFESEKESLSLSLQKLKESNEKMSNDLHSLQKSLEKSGIEYSSRIKTLMLEKQSLSEDNRKLLDNQQMMEIKLQELNGVIELEKQRFSTLEAKFTQQKNTSYSEREALLESSLSDLQSKHTSLESQYNYSLRNIEQLQAASKLAEEMVERVKTEYDEYRLQTSESLEKNHLKITSLEQRIVILQDEIASSSLRCENITKDSETRVALLLEENKHLNNELSSHRNAEKQHLEKENDYKQQLLLVTEDLRKTREDYEKELLRHADARSTLQKLREDYTKALEQVEDLNKEIALKAGINESQPFPISEKEDPLRQEVYVLKKQNAMLLTQLQSSNLNFAEITSPSPDLDSVMKLGLSDLQNHVKRISKEMEIISCQRQLLFLENKKLKRTVESSNRVIADLQRGITEKDVSSTSESVGERSNYLNMVALLNESNKSLRENLERNEEVITELREKIETLKTDLANFRLNKEQLESQLQTEKAAVKKLENSNEEYKRHNQEILLSLNSSTSTSSDASRLKNELVSKENLIEELNQEIGHLKSELETVKSKSEDLENERAQNQSKIEQLELKNTKLAAAWRTKYEQVVNKSLEKHNQIRQQLSQKTSELEAKVAECHQLNEQLNKPSATPTATTQSEPSTVSLEEFNSTKEELSSTQRKLSEIMDILNTTKEELEKVRQNSNKSEGTSKDTEIPNEEEMERKKVMQQEVLRLRSRIAKELQKNELLRKQNQVLQDQVKALQETVVSSEEAESASVHADTKDLENLKKTEEMLSVTFQVIFNESISDFSTSTADFTTFVQKEWEKRREILQKDVEEQVAQSHQKQLDNIRKELEMRNKLKLSMLEKNLARVRAELEQSKKKDSPAILSLEASKNTDSNKSNSEVPAAQVKEKKLIAKTHSVDTNSPPKRSSSDAGMDVSNDVKKAK
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (By similarity). It activates the translation of GCN4 in response to low amino acid, carbon, or purine availability, by suppressing the inhibitory effects of multiple uORFs present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. Modulation of GCN3 regulatory function in response to amino acid availability occurs post-translationally.
Miscellaneous:
MISCELLANEOUS: Present with 8970 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSEFNITETYLRFLEEDTEMTMPIAAIEALVTLLRIKTPETAAEMINTIKSSTEELIKSIPNSVSLRAGCDIFMRFVLRNLHLYGDWENCKQHLIENGQLFVSRAKKSRNKIAEIGVDFIADDDIILVHGYSRAVFSLLNHAANKFIRFRCVVTESRPSKQGNQLYTLLEQKGIPVTLIVDSAVGAVIDKVDKVFVGAEGVAESGGIINLVGTYSVGVLAHNARKPFYVVTESHKFVRMFPLSSDDLPMAGPPLDFTRRTDDLEDALRGPTIDYTAQEYITALITDLGVLTPSAVSEELIKMWYD
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MRTAKAAAEWTEDRELDLLLGEIPQVTSPQGRQRGVGVIGDGNGVHGASGCDGYASPMRLGGRRVHCPPGGDGYDAQRHAKDAYYDMVLNRRENGAPLRGGGGGGDAEGVGFPAPSPVPGPFIGSVVPPPLALGVDYPEQQLVVNQLQSLRIGDAQAALLRQGPAPVMSTTPIEVPAAHGAYHGYNFAASGSSIRHEHVFLDQAKADGYVAARPHRLVSDVGLDNFGVFPRTLDTSTGIGWGQGFVQPDFAQSYLLSSQAGNAYGGVPVADNGFVRGRNQFEAFHPDSSPTEAGAEFFSSNPAALDFRGGPKRHYAYGAIPVAEAYHCENSLMFGGKNMNFLERERKRSFRRVNNRAPELGNLRTLRFDDVVRVKEGSIYYHMAKDKNGCRYLQDKFLEGKHHVDAIFEGIINHIADLMISSAGNYLVQEMVEVCDEGQRLRIILALTQDPVKMIAISLNTHGTRVVQRLIEKVTSRELIILIISALQPGFMLLVNDPNGTHVIQKCLANFGAEDNKFIFEGAAANYFNMAVQRHGCCVLQKCISTARGRYQANLIVKICAHGFELAQDIFGNYVVQHVLKQKIPYANARLASLFEGKYIYLSKQKVSSNVVQRCIEFFPDDAKAVIVHEFLLLRGSHFEQLVTDPYANYVINTALNNTRGHLLNALVEAIRPHEDAIRTHPCCKRICRFLSRW
The following text describes a protein:
Function:
Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes (By similarity). May play a role in the degradation of engulfed apoptotic cells.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, phagosome. Note=During degradation of apoptotic cells when lysosomes fuse to phagosomes, located to phagosomal surfaces until the cell corpse is fully degraded.
Sequence:
MSFPVAFLLVLFLVPFTFATNNLVVRQKELEIVIGGEVSVNFQIKNHTSQSLNATRISLSQSPYISHPDAILVDNWNANVTVLGSQLVSGAILEALNCTTDGSITCPLDLEDAFARITVIRSHFLAILIQIVGWTYFFAWSISFYPQMYLNFKRKSVVGLNFDFLSLNLVGFCAYAIFNLLMYYNSHVKNEYNIVNPRSPPPVLLNDVVFAVHAFLACFITILQCLFYERDNQSVSSKCIALMIVLISFGFCSAAATVLRKIQLLSFVTSLSYIKMAVTCCKYFPQAYFNYTRKSTVGWSIGNIMLDFTGGTLDILQMILQAVNVNDWSAFYANPVKFGLGFVSIFFDIIFMVQHYVLYPNAEVPHNEYHGVDNPNPDNIARDAEQYAGDSESMESTEPIIVHD
The following text describes a protein:
Function:
Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis.
Subcellular Localization:
Secreted.
Sequence:
MMRDLALAGMLISLAFLSLLPSGCPQQTTEDACSVQILVPGLKGDSGEKGNKGAPGRPGRVGPTGEKGDMGDKGQKGTVGRHGKIGPIGAKGEKGDSGDIGPPGPSGEPGIPCECSQLRKAIGEMDNQVTQLTTEIKFIKNEMQVLALSALPSPAAVAGVRETESKIYLLVKEEKRYADAQLSCQGRGGTLSMPKDEAANGLMASYLAQAGLARVFIGINDLEREGAFVYSDRSPMQTFNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHITMYFMCEFDKENL
The following text describes a protein:
Function:
Involved in maintaining cell viability under glucose starvation conditions. May have a role in regulating genes involved in gluconeogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MKSYECPFCKRVFHRQEHQVRHIRSHTGEKPFECSYPSCKKRFTRRDELIRHVRTHLRKALVTPEQTLDVNLHKAPDSKPEGDKSTGQEADKSQNQSKDGSITDPVQAAVLALSVAYAKPTSVSLSPTDLQAQSKLIEKPRRRSASNATGSLNKKNQDPLRRFSISESAGAAAPTPSPSNSKSPPSENRKNRLQNVLSPIASNNVPDFNQNYPTESNPMFLSTPRFQNTNGQRTLTVPVSVWDARQPPTSSRSGLPLSVMYNHFPSVPIPPATVNDTSMEYYLPNAYPHPTGISLPFYPFDSGIPVSPNIPVSPSSSFVPMYPTTFPSSKPQIVNAPPAPSYFSPGSSFGAQLCANGSTLLRADTKQYGLALPKITNSNLISPNQTFNPVKSSVKALPTLEPPSSPSHATATSSLHTLFHTAPSRSYD
The following text describes a protein:
Function:
Confers hyper-resistance to brefeldin A (BFA), an inhibitor of intracellular protein transport. Could serve as an efflux pump of various antibiotics.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNQNSDTTHGQALGSTLNHTTEVTRISNSSDHFEDSSSNVDESLDSSNPSSNEKASHTNEEYRSKGNQSYVPSSSNEPSPESSSNSDSSSSDDSSVDRLAGDPFELGENFNLKHYLRAYKDSLQRDDIITRSSGVCMRDHSVYGVGSGYEFLKTFPDIFLQPYRAITEKQVVEKAILSHCHALANAGELVMVLGQPGSGCSTFLRSVTSDTVHYKRVEGTTHYDGIDKADMKKFFPGDLLYSGENDVHFPSLTTAETLDFAAKCRTPNNRPCNLTRQEYVSRERHLIATAFGLTHTFNTKVGNDFVRGVSGGERKRVTISEGFATRPTIACWDNSTRGLDSSTAFEFVNVLRTCANELKMTSFVTAYQASEKIYKLFDRICVLYAGRQIYYGPADKAKQYFLDMGFDCHPRETTPDFLTAISDPKARFPRKGFENRVPRTPDEFEQMWRNSSVYADLMAEMESYDKRWTETTPASSEAPEKDNFGSDISATTKHELYRQSAVAEKSKRVKDTSPYTVTFSQQLWYCLARSWERYINDPAYIGSMAFAFLFQSLIIGSIFYDMKLNTVDVFSRGGVLFFSILFCALQSLSEIANMFSQRPIIAKHRASALYHPAADVISSLIVDLPFRFINISVFSIVLYFLTNLKRTAGGFWTYFLFLFIGATCMSAFFRSLAGIMPNVESASALGGIGVLAIAIYTGYAIPNIDVGWWFRWIAYLDPLQFGFESLMINEFKARQFECSQLIPYGSGYDNYPVANKICPVTSAEPGTDYVDGSTYLYISFNYKTRQLWRNLAIIIGYYAFLVFVNIVASETLNFNDLKGEYLVFRRGHAPDAVKAAVNEGGKPLDLETGQDTQGGDVVKESPDNEEELNKEYEGIEKGHDIFSWRNLNYDIQIKGEHRRLLNGVQGFVVPGKLTALMGESGAGKTTLLNVLAQRVDTGVVTGDMLVNGRGLDSTFQRRTGYVQQQDVHIGESTVREALRFSAALRQPASVPLSEKYEYVESVIKLLEMESYAEAIIGTPGSGLNVEQRKRATIGVELAAKPALLLFLDEPTSGLDSQSAWSIVCFLRKLADAGQAILCTIHQPSAVLFDQFDRLLLLQKGGKTVYFGDIGEHSKTLLNYFESHGAVHCPDDGNPAEYILDVIGAGATATTNRDWHEVWNNSEERKAISAELDKINASFSNSEDKKTLSKEDRSTYAMPLWFQVKMVMTRNFQSYWREPSILMSKLALDIFAGLFIGFTFYNQGLGVQNIQNKLFAVFMATVLAVPLINGLQPKFIELRNVFEVREKPSNIYSWVAFVFSAIIVEIPFNLVFGTLFFLCWFYPIKFYKHIHHPGDKTGYAWLLYMFFQMYFSTFGQAVASACPNAQTASVVNSLLFTFVITFNGVLQPNSNLVGFWHWMHSLTPFTYLIEGLLSDLVHGLPVECKSHEMLTINPPSGQTCGEYMSAFLTNNTAAGNLLNPNATTSCSYCPYQTADQFLERFSMRYTHRWRNLGIFVGYVFFNIFAVLLLFYVFRVMKLRSTWLGKKITGTG
The following text describes a protein:
Function:
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers.
Domain:
Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12; The ATG16L1-binding motif mediates interaction with ATG16L1.
Sequence:
MPHTLWMVWVLGVIISLSKEESSNQASLSCDHNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRYVNLQALVLTSNGINTIEEDSFSSLGRLEHLDLSYNYLSNLSSSWFKPLSSLKFLNLLGNPYKTLGETSLFSHLTKLRILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDLTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLSQISGLLELEFDDCTLNGVGDFRGSDNDRVIDPGKVETVTIRRLHIPQFYSFNDLSTLYPLTERVKRITVENSKVFLVPCLLSRHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLGKTGETLLTLKNLTNLDISKNTFHYMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDISNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNTITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLVDWPANYLCDSPSHVRGQRVQDVRLSVSECHRAALVSGMCCALFLLILLMGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPNRDICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILVLLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEARQEGFWVNLRAAIKS
The following text describes a protein:
Function:
Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
Sequence:
MAEGKAMSEFLPFSRPAMGVEELAAVKEVLESGWITTGPKNQALEQAFCQLTGNQHAIAVSSATAGMHITLMALKIGKGDEVITPSLTWVSTLNMISLLGATPVMVDVDRDTLMVTPEAIESAITPRTKAIIPVHYAGAPADIDAIRAIGERYGIAVIEDAAHAVGTYYKGRHIGAKGTAIFSFHAIKNITCAEGGLIVTDNENLARQLRMLKFHGLGVDAYDRQTWGRAPQAEVLTPGYKYNLTDINAAIALTQLVKLEHLNTRRREIAQQYQQALAALPFQPLSLPAWPHVHAWHLFIIRVDEQRCGISRDALMEALKERGIGTGLHFRAAHTQKYYRERFPTLSLPNTEWNSERICSLPLFPDMTTADADHVITALQQLAGQ
The following text describes a protein:
Function:
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (By similarity). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor. Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytosol. Cell membrane. Synapse. Cytoplasm, cytoskeleton. Nucleus. Nucleus speckle. Nucleus matrix. Note=Translocates to the plasma membrane in response to steroid hormone receptor stimulation. Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH. Translocates to the nucleus in response to thrombin stimulation (By similarity). Association with the nuclear matrix is regulated by nerve growth factor.
Domain:
The L-X-X-L-L repeats are both required for binding and phosphatidic acid-mediated activation of the nuclear receptor NR5A1.
Sequence:
MATAAESGARTWPGSGSPRLGSPAGSPVLGISGRARPGSGPERTGRAIGSVAPGHSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLKQVKTPCTSIAPSLVRVPVAHCFGSLGLYKRKFCVVCRKSLEVPAFRCEVCELHVHPDCVPFACSDCRQCHQDGQHDYDTYHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSVCSTALTPECTFGRLRSMVLPPSCVRLLSRNFSKMHCFRIPETMVLELGDGDDGLDGSAAVGTGREVSAATESTKQTLKIFDGNDSMRKNQFRLVTVSRLARNEEVMEAALRAYYINEDPKDFQLQALPLTLLSGNAQALGKAGTTEEETSKDSGPGDSVPEAWVIRSLPRTQEILKIYPDWLKVGVAYVSIRVNSQSTARSVVQEVLPLFGRQVEDQERFQLIEVLMSSRQVQRTVLVDEEPLLDRLRDIRQTSVRQASQTRFYVAEARAVTPHVSLFVGGLPPGLSPQDYSNLLHEAMATKAAVVSVSHVYSLQGAVVLDVTCFAEAERLYMLARDTAVHGRPLTALVLPDVLHTKLPPDCCPLLVFVNPKSGGLKGRELLCSFRKLLNPHQVFELTNGGPLPGFHLFSQVPCFRVLVCGGDGTVGWVLAALEETRRHLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLVSVDEADAVLMDRWTILLDAHEIDSTENNVVETEPPKIVQMNNYCGIGIDAELSLDFHQAREEEPGKFTSRFHNKGVYVRVGLQKISHSRSLHKEIRLQVEQQEVELPSIEGLIFINIPSWGSGADLWGSDSDSRFEKPRIDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWIQAPGHMIISATAPKVHMLRKAKQKPRKAGAIRDTRVDTLPAPEGNPL
The following text describes a protein:
Function:
Plays a role during the calcification of cartilage and the transition of cartilage to bone.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Note=Found on some small banded collagen fibrils and filamentous meshworks.
Domain:
The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).
Sequence:
MGTGFARGARGTAASGPGGGFLFAWILVSFTCHLASTQGAPEDVDVLQRLGLSWTKAGGGRSPTPPGVIPFPSGFIFTQRAKLQAPTANVLPTTLGRELALVLSLCSHRVNHAFLFAIRSRKHKLQLGLQFLPGRTIIHLGPRQSVAFDLDVHDGRWHHLALELRGRTVTMVTACGQHRVPVPLPSRRDSMLDPQGSFLLGKVNPRAVQFEGALCQFSIHPVAQVAHNYCAHLRERCRQVDTYSPQVGTLFPWDSGPAFALHPEPALLGLGNLTRTPATLGARPVSRALAVTLAPAMPTKPLRTVHPDVSEHSSSQTPLSPAKQSARKTPSPSSSASLANSTRVYRPAAAQPRQITTTSPTKRSPTKPSVSPLSVTPMKSPHATQKTGVPSFTKPVPPTQKPAPFTSYLAPSKASSPTVRPVQKTFMTPRPPVPSPQPLRPTTGLSKKFTNPTVAKSKSKTTSWASKPVLARSSVPKTLQQTVLSQSPVSYLGSQTLAPALPPLGVGNPRTMPPTRDSALTPAGSKKFTGRETSKKTRQKSSPRKPEPLSPGKSARDASPRDLTTKPSRPSTPALVLAPAYLLSSSPQPTSSSFPFFHLLGPTPFPMLMGPPGSKGDCGLPGPPGLPGLPGSPGARGPRGPPGPYGNPGPPGPPGAKGQKGDPGLSPGQAHDGAKGNMGLPGLSGNPGPLGRKGHKGHPGAAGHPGEQGQPGPEGSPGAKGYPGRQGFPGPVGDPGPKGSRGYIGLPGLFGLPGSDGERGLPGVPGKRGEMGRPGFPGDFGERGPPGLDGNPGEIGLPGPPGVLGLIGDTGALGPVGYPGPKGMKGLMGGVGEPGLKGDKGEQGVPGVSGDPGFQGDKGSHGLPGLPGGRGKPGPLGKAGDKGSLGFPGPPGPEGFPGDIGPPGDNGPEGMKGKPGARGLPGPPGQLGPEGDEGPMGPPGVPGLEGQPGRKGFPGRPGLDGSKGEPGDPGRPGPVGEQGLMGFIGLVGEPGIVGEKGDRGVMGPPGAPGPKGSMGHPGTPGGIGNPGEPGPWGPPGSRGLPGMRGAKGHRGPRGPDGPAGEQGSKGLKGRVGPRGRPGQPGQQGAAGERGHSGAKGFLGIPGPSGPPGAKGLPGEPGSQGPQGPVGPPGEMGPKGPPGAVGEPGLPGDSGMKGDLGPLGPPGEQGLIGQRGEPGLEGDHGPVGPDGLKGDRGDPGPDGEHGEKGQEGLKGEDGSPGPPGITGVPGREGKPGKQGEKGQRGAKGAKGHQGYLGEMGIPGEPGPPGTPGPKGSRGTLGPTGAPGRMGAQGEPGLAGYNGHKGITGPLGPPGPKGEKGDQGEDGKTEGPPGPPGDRGPVGDRGDRGEPGDPGYPGQEGVQGLRGEPGQQGQPGHPGPRGRPGPKGSKGEEGPKGKPGKAGPSGRRGTQGLQGLPGPRGVVGRQGPEGTAGSDGIPGRDGRPGYQGDQGNDGDPGPVGPAGRRGNPGVAGLPGAQGPPGFKGESGLPGQLGPPGKRGTEGGTGLPGNQGEPGSKGQPGDSGEMGFPGVAGLFGPKGPPGDIGFKGIQGPRGPPGLMGKEGIIGPPGMLGPSGLPGPKGDRGSRGDLGLQGPRGPPGPRGRPGPPGPPWHPIQFQQDDLGAAFQTWMDAQGAVRSEGYSYPDQLALDQGGEIFKTLHYLSNLIQSIKTPLGTKENPARVCRDLMDCEQRMADGTYWVDPNLGCSSDTIEVSCNFTQGGQTCLKPITASKAEFAVSRVQMNFLHLLSSEGTQHITIHCLNMTVWQEGPGRSSARQAVRFRAWNGQVFEAGGQFRPEVSMDGCKVHDGRWHQTLFTFRTQDPQQLPIVSVDNLPPVSSGKQYRLEVGPACFL
The following text describes a protein:
Function:
Serine protease inhibitor that inhibits proclotting enzyme and to a lesser extent clotting factor C and clotting factor G.
Subcellular Localization:
Secreted. Note=Localizes in the large granules of hemocytes. Secreted in hemolymph in response to external stimuli.
Sequence:
MLSRRTLDCCLVMLIVSTTFCQELHFYKEKADRSHENLKTAVNQFGIHLCRRLLNEGKNIIFSPFSLSTALSMAFVGARGNTAIEMRSGLGFREAGLAQEDVPDSFYQAFQLLKSDQSGDKFYVANTALVQNNYNILNSYKRILHRKFYSDIQPVDFVRNGLWVKEMVNKWVSNITHNKITSLIDKPLSPLTRLFLLNAVYFKGSWKTQFDRKRTTLSLFYNNNKVARRVEMMSLTNKFPYTYDSELKCQVLELPYDGDKTSMIFILPEWDVRLKHVENALSAQSVKQLINNLQDTEIVVTIPKFKLENSPQIKEYLQVMGMNEAFSFSADFSGMNGRRNLFVKDVLHKAMIDVNEEGSEAAAVSGVVVMLKSASHNLPTFVANHPFMFLIINKESGMILFLGSVREL
The following text describes a protein:
Function:
Scaffolding protein that is necessary to cluster acetylcholine receptors at neuromuscular junctions.
Subcellular Localization:
Synapse. Secreted. Note=Secreted by muscle cells and localizes at cholinergic neuromuscular junctions.
Sequence:
MRFLLLLAISITYASALSCPEVTLSQRPKHCKKECIADEDCKRNKRCMCDGECGLSCVNPIAMCHPLPNIENGFIRTAGDLRFGSNAEYGCNKGYILVGASQRRCQANKEWSSSQPVCRLQLKCGPPPEIPFAVHDGSSFSGEYDLDAEVAYNCIPGYHKFNAKGLSISKCLLNRKNVAQWFGPDLRCKARACPDPGDIENGLREGDTFEYPHHVKYSCNPGFLLVGSTSRQCSSNGEWTNEPANCKATECSRPSSPLHGKVVGSSLTYQSVVTYSCDHGYRLVGQVQRICLAEGIWGGNEPRCEEIRCSVLPTLPNGYIEGSETSFGAVAVFRCLETMTHEGASKAKCMEDGQWSAPIPRCLASCRVPHIQNGKIRDKSEGQLIASGSKVIVECNKQHEANIDERLICSNSTWSHVPVCSPLSCHNWPPRVPHARILFSKSSHGSIAKYECNNGYHPNRNNQIIKCLYGEWTKDGPPMKCLPSWCEHPSKTYGTLPGGQILLEGILGAYEFQSYIQKVEEGRAISFQCGKGNYLIGPPKATCVNGEWMPKVSPKCVSQTHPMIEGKILWDRKKRSLPGRAVREYVDDELSTHRQHSGKCGIVSGKLERMIMQHSDNGVSVC