lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Subcellular Localization:
Nucleus.
Sequence:
MLNLQIEQQTEEDIRASQSIIAHINVCIALLDESNKKEVEAQVNSILEKSPLSVYISYWKKLVQQSSQYIKEHQKLDLRKPTHYLLYNLFRDIVHKNSETVEVLNSAIFEDVAFLDQQHLTKKEILAVLDPTEDKEVIRRLEPEEYINKLKRVKQLQMNTFQALQDFVLKENPHTLEEILANLLLSLEGESLNDFIALILSEILSPGSQGLQSSSNSWFTPIAVAEATQRGAQISNALSKLNPSAVNWNRVFNLMSTKYFLNRVIAPTLASLSATFSALGNGLLIDQFFNCDWNLVFKLNLAILLHQWNPQQGCIDLLQTKDLRKVSKVLPNSKNSLLYLTSVSKLDIELFLSREEFGSSPMFQLFHDCFFDDYNIVPEYLALTLISETKHFSLMVENKAIINELLVTLMVQVFEKSPMVFGELIKKIPNHKVIEVGRIIINKDTTPLANFVQILYEEKKLEDFIRSIPFKESLKITPSARKVGWTGFEEYIKSKLSPESVNTIIDFIDLQASMDDQNTPFRSSRVYDLSALHFVVTLLDAYTLPKETRRRLNDVEYKLLNTFPRLINFGHGHDEAILANGDLVPIATDVEKEMQTYLQKMYNKEMQIKDVVDILRKLRDSDNSRDQDIFSCITHAVIAETKFFKEYPLEALATTSVLFGSMILFDLLRGFVLDVAFKIIADFAMEGPESKMFKFSVQALYAFRIRLHEFPEFCRSLVDEIPSLQSQPQIFQILAESAAQTSGKASGSAGAFPQIPDMITLNYFNVNELPVNVPQENPAREITEKVLFVVNNITMDNFSGKIADLTNLLEEKYYAWFSNYLVNQRAKTEPNYHELYANMLEAVDSKLLHKYMLNSTYKQLYLLLSTKDISSNDKNHLKNLGAWLGNITLGVDKPIRHRNIAFRELLLDSYKKGRLEIVVPFVTKVLQQAANSRVFRPPSPWTVGILRVLLELNEKANWKLNLTFEVEVLFKALGLKLTDLKPSKFVDIPEVTEYLAGNLRTLTIEQQQIEQQQQLISMQTYQQQLALLHRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSQQPQPQQTQQQMQQTQQQPQTQSTAHQQAQAQQSQQQQQMHAMSNNVNLHGEQPPMDGDGIFNNLVGQSAFVTHPDLKLLFMMAMSKAIREILVPTVEKSTSIAVITTISIMLKDFATEVDEIKLKTAAIGMVRKLAQSLAHSTSIELLKENIRTHTQALTPNLISINMNHSPLEELNMAIDDNINSALAPIEKAAMDKVTQDIGDQLMQAIAIRRYHKERRSDQPFLAPNASNYALSLPEPLGLKTTGITPQQFRIYEEFAKLSVVPEQVMHMAPNHAVSSQQVANNQLLQQQKILQQQMQQSQTQIQTDATHQQPLQQPLAAQPQIHPPLNRIQTELEQNQKVLVQFMDRLVLHIKENADKKLSDLGSDNAIKETIYQILTFIARSAQKDQLALKVSQAVVNSLFGTSESVLCREVLSLLLEKLCSLSIVARKDVIWWLVYALDTRKFNVPVIRALLEVNLIDIAELDAVLVTAMKNSMDGAIRFAMDLIRDTTLSNNPILMRLDFVCTLEYLRLFDLEETRAFFKEFEECKIMPVAKNTKATNKERIWLVFTEWVKLLQRVSSNDVVTTVFMRQLMDRGVLDSSDKTIEFVKASLELAVSSFKESDPTGEVFTAVDALSNLIARLLYLQDFSQTSRTDYLNLIFSTVTLVFAKDHEVNDSTFNERPYFRFFSSLLCEWESLRGHNFIKIKDEQCRNELLSFDTDFFNTFASFLHCYQSIAFPGFAFAWITLISHRMFLPNVLRLPNNAGWHSCVLLLSDLLKFLSQYIKKEETSDAVSVVYKGTLRIFLAIANDVPEFLVQNHYELINNVPRSCIQLKNIILSSFPKKMLLPDPYRTDLELDRLELCEQPPKVFYDPVQDLKNLKKPVDNYLRIPSASLIRTISAGVLRSEYEYEAGIGYDINTVDVKLINAIVLHVGIEAALEKQKTSFNAVFSTNATYYTLLSSLINEGSIEVKFHVIQAMVNQLRYPNAHTHWFNFVLRNMFVSDQWGDQTLDVQEIIIRSLLERIITSKPHCWGVVFTFVSLLRMDNIKLQELPFINDTPEMKLIFQNLSKYLVNSTNSNDKQSHETPLEQQS
The following text describes a protein:
Function:
Can hydrolyze the glycosidic link of O-GlcNAcylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates (in vitro).
Miscellaneous:
MISCELLANEOUS: Metal-binding observed in X-ray crystal structures is artifactual.
Sequence:
MKNNKIYLLGACLLCAVTTFAQNVSLQPPPQQLIVQNKTIDLPAVYQLNGGEEANPHAVKVLKELLSGKQSSKKGMLISIGEKGDKSVRKYSRQIPDHKEGYYLSVNEKEIVLAGNDERGTYYALQTFAQLLKDGKLPEVEIKDYPSVRYRGVVEGFYGTPWSHQARLSQLKFYGKNKMNTYIYGPKDDPYHSAPNWRLPYPDKEAAQLQELVAVANENEVDFVWAIHPGQDIKWNKEDRDLLLAKFEKMYQLGVRSFAVFFDDISGEGTNPQKQAELLNYIDEKFAQVKPDINQLVMCPTEYNKSWSNPNGNYLTTLGDKLNPSIQIMWTGDRVISDITRDGISWINERIKRPAYIWWNFPVSDYVRDHLLLGPVYGNDTTIAKEMSGFVTNPMEHAESSKIAIYSVASYAWNPAKYDTWQTWKDAIRTILPSAAEELECFAMHNSDLGPNGHGYRREESMDIQPAAERFLKAFKEGKNYDKADFETLQYTFERMKESADILLMNTENKPLIVEITPWVHQFKLTAEMGEEVLKMVEGRNESYFLRKYNHVKALQQQMFYIDQTSNQNPYQPGVKTATRVIKPLIDRTFATVVKFFNQKFNAHLDATTDYMPHKMISNVEQIKNLPLQVKANRVLISPANEVVKWAAGNSVEIELDAIYPGENIQINFGKDAPCTWGRLEISTDGKEWKTVDLKQKESRLSAGLQKAPVKFVRFTNVSDEEQQVYLRQFVLTIEKK
The following text describes a protein:
Function:
Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P.
Sequence:
MGKPLLQIALDAQYLETALVDVKQIEHNIDIIEVGTILACSEGMRAVRILRALYPNQILVCDLKTTDAGATLAKMAFEAGADWLTVSAAAHPATKAACQKVAEEFNKIQPNLGVPKEIQIELYGNWNFDEVKNWLQLGIKQAIYHRSRDAELSGLSWSNQDIENIEKLDSLGIELSITGGITPDDLHLFKNTKNLKAFIAGRALVGKSGREIAEQLKQKIGQFWI
The following text describes a protein:
Function:
Potentially involved in docking of synaptic vesicles at presynaptic active zones.
Subcellular Localization:
Membrane; Single-pass type IV membrane protein.
Sequence:
MSDFHNIRSRRRIPEASSYSTVDFDYDPDQKNHTSAVAPTSFAYSSLTTVFNASASQLWNSAQEALVSSYDTAEGTESIDADRSKVVETLESLSIFGNPLDHIIITMPSRDRTSEFRATAKSYEMKAAANGIRPQPKHEMLSESVQFNQLAKRIGKELSQTCAKMEKLAEYAKKKSCYEERSQIDHLSSIVKSDITGLNKQIGQLQEFSKRRAGNMKNQNSGHIQLVVVGLQSKLANVGKDYQSVLEISTETMKAEKNRRDKFSSGAAVPMGLPSSSSGANVRSKLLQDDEQHGSSSIALDMGALSNMQSQQTMQQRDSSLEYAQARSNTMATIEGSISELGQIFSQLASLVSEQGEMITRIDSNVEDTALNIDMAHSELVRYLQNISKNRWLMIQVFGVLMVFFVVFVLFLT
The following text describes a protein:
Function:
Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.
Subcellular Localization:
Virion membrane; Multi-pass membrane protein. Host Golgi apparatus, host trans-Golgi network. Host endosome membrane; Multi-pass membrane protein. Host nucleus inner membrane; Multi-pass membrane protein. Note=During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs.
Sequence:
MAPSHVDKVNTRTWSASIVFMVLTFVNVSVHLVLSNFPHLGYPCVYYHVVDFERLNMSAYNVMHLHTPMLFLDSVQLVCYAVFMQLVFLAVTIYYLVCWIKISMRKDKGMSLNQSTRDISYMGDSLTAFLFILSMDTFQLFTLTMSFRLPSMIAFMAAVHFFCLTIFNVSMVTQYRSYKRSLFFFSRLHPKLKGTVQFRTLIVNLVEVALGFNTTVVAMALCYGFGNNFFVRTGHMVLAVFVVYAIISIIYFLLIEAVFFQYVKVQFGYHLGAFFGLCGLIYPIVQYDTFLSNEYRTGISWSFGMLFFIWAMFTTCRAVRYFRGRGSGSVKYQALATASGEEVAALSHHDSLESRRLREEEDDDDEDFEDA
The following text describes a protein:
Function:
Nucleotide-sugar transporter that transports UDP-rhamnose or UDP-galactose and UMP in a strict counter-exchange mode.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MAAENERKSPSAVSDMGAWAMNVISSVGIIMANKQLMSSSGFAFSFATTLTGFHFALTALVGMVSNATGFSASKHVPMWELIWFSIVANVSIAAMNFSLMLNSVGFYQISKLSMIPVVCVMEWILHSKRYSREVKISVVVVVVGVGICTVTDVKVNAKGFICACVAIFSSSLQQILIGSLQKKYSIGSFELLSKTAPIQAFSLLVVGPLVDYLLSGKFIMKYNMSSGCFLFILLSCGLAVFCNISQYLCIGRFSAVSFQVIGHMKTVCILTLGWLLFDSAMTFKNVAGMIVAIVGMVIYSWAMELEKQSIIAAKALNSVKHSLTEEEFELLKEGVETTQSKDVELGRTKD
The following text describes a protein:
Function:
Polymerase that creates the 3'-poly(A) tail of mRNA's.
Subcellular Localization:
Nucleus.
Sequence:
MEFGIFENQLSHLNPPFTRILGFRRSPDVILRMEMERSMSLFQMMVNEGLVPSAEEEMKRRNAIDKLKKIVVEWVKTVTYQRGLPKKYLKFASGTILTYGSYGLGVYNSESDIDALCVGPYFATIAEDFFIVLHNMLASRPEVSEIHCVKDAKVPLMRFKFDGISIDLPYARLKVISIPENVDVFNPFFLKNIDDTTWKSLSGVRANRSILHLVPNIEIFQAVLRCIKFWAKRRGVYGNLLGFFGGIHLAVLSAFICQRHPSASLSALILLFFKTFGLWPWPTPVILQETIARPFIPADKVSWMPIQLPCSPYEFCHSNITRSTFYKIRTEFLRGHMLTKDMLRPDFDWNILFEPFPYARRYGLFVKIFLSACDKDELGDWVGWIKSRFRSLLVKLEELLGFCDPNPTEYVDTDASEPNVIFYWGLPTGRSDLIDADLVEEYFLKSIDNGYQGATGKMKLSVVKANQLPKKAQFAFERKNTKPCWRVVDDNRKKTNPQSKYKPHCADKYLPTNDSPEYPSAGG
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Sequence:
MKVLLTRPEGRNQSMVDALNERGIEHCVTPLLCVEATPALPPETSHPLANVDMVVCISANAVSFADDTFKANDANVKGWPKVPYFAVGHATWEALQQIDIDALEAPDDCQQTEGLLTLPTLQHIQGKKITIIRGVGGREALAEQLTSRGAQVRYWEVYQRACPPLDGTIITQQWIDLGIDTVVVTSGEVLDNLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNALKL
The following text describes a protein:
Function:
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
Subcellular Localization:
Cytoplasm.
Sequence:
MSQTLVATQLRNPEHAYSGLTYGSKELVDKLKKENKLGESDQLFVIINGYIFVFKGDADYRKNEIGANKYQRELLKMTISQEVEFQVFKLPKDKEYRLKVLDLEIDIQSLGNGGNQIELDDDEFAKLFKTQFRGQFFKTGQVQLFQHNQNHYLIKVTRTENLSVETDQNLKKFVGGGMLFDNTEIEFSVRSGISQLKMKNVQKKTATLFKDDFNFDQLGVGGLDKELADIFRRAFSSRRFSQQYLEKYGIKHIKGLLLYGPPGTGKTLIARQLANVLRARPPKIVNGPEIFSKYVGEAEENIRKLFADAIKDQETLGDESDLHIIVFDEMDAICKQRGSVSSGVGAYDNVVNQLLSMIDGVNSLNNILVIGMTNRKDLIDEAVLRPGRFEVHIEVGLPDEKGRQQIFQIHTENLRKNQALYKDVNNEELATLTKNYTGAEIEAVVKSASSFAFQRIQNIFNFSQRVNQQDDLKITRADFQNALEEVKPQFGFDSNKFDLLLKNQLIDFGDEFQKLQKMLRGTINQTRFGKSSKLNSILLEGYQGSGKTSVAAYFAVECGFPYVKLISPECFIGMTEDAIINKISKIFNDAYKSSLSCIVIDNIERLIEYVDIGPRFSNSILQALLVLIKRLPDKTQNKLMIVGTTSSYQILKQLGVVSCFNLTFKVPNLSKKEEIRTVIYNYMNIPDKDDKSEKQKKQRAQIEKICSTIDNIPIKRLLMLLDMVCTDENELNYEEFKSCYQMAQMNHS
The following text describes a protein:
Function:
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
SSPKRAISAPKTEVTSPNKKKKQDNEENEENTPPVRSPKKSPKKVPQFGTRVVLLKNALHNAAPKRLIGRESELKEIEDFIEDLVETKKSGSLYISGAPGTGKSACLSQALSDPKVTSKLAQSISINCMSVRTASQIYQQIATEMGANSKESKSARTALKFIENDLTTRESMILLLLDEMDQLDSRNHEVLYTMFGWSALPNSKVILIGIANSLDLTDRILPRLQARLECKPKLLNFKPYSKDQLANILQARISKASRGHDDIKVVDAMAVQFCARKIAATSGDARKALDVCRRAVELVETNSLGNTAGEFLTGNTKFLLSESTTKVGIRQISSVMDGVYGNVYSSHGGATEADDAFPLQQKLVVCSLLLLCKKTKSYEAPLGKLRETYTTICKDRQVSAVSQSEFHSLCDLVEARGLVSLRRHKQPRLAKIKLNVDEKEIEFALKGKALLSSILQRGISK
The following text describes a protein:
Function:
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates atg12 for its conjugation with atg5 and atg8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the atg8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity). Plays a role in meiosis and sporulation.
Subcellular Localization:
Cytoplasm. Nucleus. Preautophagosomal structure membrane; Peripheral membrane protein.
Domain:
The GxGxxG motif is important for the function, possibly through binding with ATP.
Sequence:
MFVGKALQFQSFHSSIDATFWHQLSNYKVEKQKLDASPLTIHGKFNTYSRGNISIVFGEAPSNSNIKDCLAEGTLLNANTPQEFTNADVKKIREEIGEVLLNSIKNGVVSERPNELLRFLIFSYADIKAYKYHYWCLFPSFKETPHWIVKDLSPAESLIPSGPILSQIREFLSTADYYQRPFFLLIKSTLDEWTIAPLKELSHCVDKSLQFYLVAEDSVQLAEYPSWPVRNILAFAFIKFKLKVINLFLYRDGINSDTLSKSILIKVEADKDMILEAPLSIVGWERNGKGVLGPRVVNLSTVLDPFVLSESASTLNLSLMRWRLVPQLDLDRIQNSKCLLLGAGTLGCGVARNLLSWGVRHVTFVDYSTVSYSNPVRQSLFTFEDCKRKLPKAECAAQRLKEIYPNMFSTGYNISIPMLGHPIYEAGIEKTMHDYETLENLISTHDAIFLLTDTRESRWLPTVISTAMDKLLINSALGFDSWLVMRHGSVLQKENRLGCYFCNDIFAPSNSLVDRTLDQTCTVTRSGCANIATAIAVELFVSLLQHPNGHAAPVLNEDQTVLGELPHQIRGFLHNFSLMKISGMAYPQCSACSECIINEWNREKWMFVLRAINEPDYVEELCGLREVQALGEIAGTMEEWISDKESVIL
The following text describes a protein:
Function:
Component of the RNA-directed DNA methylation (RdDM) machinery, probably by facilitating an RNAi-mediated epigenetic modification involving secondary siRNAs and spreading of DNA methylation, thus leading to gene silencing. Involved in the assembly of RNA polymerase V (Pol V) transcription initiation or elongation complexes at the chromatin, as a component of the DDR complex. Required for de novo DNA methylation.
Subcellular Localization:
Nucleus.
Sequence:
MYPTGQQISFQTTPLNVQDPTRMMNLDQSSPVARNETQNGGGIAHAEFAMFNSKRLESDLEAMGNKIKQHEDNLKFLKSQKNKMDEAIVDLQVHMSKLNSSPTPRSENSDNSLQGEDINAQILRHENSAAGVLSLVETLHGAQASQLMLTKGVVGVVAKLGKVNDENLSQILSNYLGTRSMLAVVCRNYESVTALEAYDNHGNIDINAGLHCLGSSIGREIGDSFDAICLENLRPYVGQHIADDLQRRLDLLKPKLPNGECPPGFLGFAVNMIQIDPAYLLCVTSYGYGLRETLFYNLFSRLQVYKTRADMISALPCISDGAVSLDGGIIRKTGIFNLGNRDEVNVRFAKPTASRTMDNYSEAEKKMKELKWKKEKTLEDIKREQVLREHAVFNFGKKKEEFVRCLAQSSCTNQPMNTPR
The following text describes a protein:
Function:
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF13, together with TAF11 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes.
Subcellular Localization:
Nucleus.
Sequence:
MADEDEDQTFEDETEEASGSAEGGQGRRKRLFSKELRCMMYGFGDDQNPYTESVDILEDLVIEFITEMIHKAMSIGRQGRVQVEDIVFLIRKDPRKFARVKDLLTMNEELKRARKAFDEANYGS
The following text describes a protein:
Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MPRKVVSGPDYDDEYDDDYDEYDEDYDDYGETGHSDDIQHPVKEEKESSKKSSSTVPVLWRCSMCMFDNHESMVYCEMCGVFRESFMKSAKDGSIKVHGIPSDFGTPSMPKSDCTKMPVNTRTTDFDGDPEIKNASISHEKVGSTQYTSAGSSSGAGKKLKEDQSSRASSSAQNEDVAQKLSSDIQKLGLEKNEVDTAKPYLPEEYKPEKWMFANEESGVLSQLNLAIVGHVDSGKSTLSGRLLHLLGRISKKDMHKNEKEAKEKGKGSFAYAWAMDESSEERERGVTMTVAVAYLETKKYRVVLLDSPGHKDFVPNMISGATQADAAILVVDACTGSFEAGMDGEGGKSVGQTKEHAQLIRSFGVEQLIVAVNKMDAIGYSKERFEFIKVQLGSFLRSCNFKDSSVTWIPLSAVENQNLIKIPSDVRLTSWYQGFCLLDAIDSLQLPSRDVSKPLILPICDVIKSQSTGQFAAFGKLETGAIRIGSKVLISPCGEVAAVKSIERDSNSCDIARAGDNVAVSLQGIDGSKLILGGILCNPGFPVPVSNFLELRVLVLDVTIPILIGYQVEFHIHHVKEAARVTKIVALLDKAGKPSKTAPRFLKSKQNAVVQVTLDAPVCVQEFSKCRALGRAFLRSSGSTIAVGVVTRVLRQDQN
The following text describes a protein:
Function:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The FZ domain is involved in binding with Wnt ligands.
Sequence:
MKPTCILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQEQDLYGLPGQGIPGGLGGKLPMDCSGLAKSHLYVRLPRSGRCAPLCEADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIWCHNMVTLGWAVRFMVGRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTNTPLWPFLLRAFMELMLGICCFAWVLGPSISTLYKRQVSNGKMVKHTSAGAATGHLDGHSSSRGSHAACNSTVVSYHSVRTSMASVPLPPSPYKLKTSPGTGSISLNQMSNYSLGRSVHHQQRHSPHHHHHQQQQHHQFHPHHNHQHHSTSSHRLYYPPGSYASQKYSQHGSYYPHLQQYGNETLL
The following text describes a protein:
Function:
Sulphite efflux pump required for the secretion of sulphite as a reducing agent. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. Excretion of sulphite mediated by an efflux pump also represents a detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGTGIVAVLLHTLSDLYPSHHHSLHTLSIVFFVLNVFLFAMIFIISILRYALYPATWSLMLQHPVQSLFLGTLPMGFATIINMFVAVCVPAWGGKAPYYAWAMWWLDVGVSIACCLGLPFQMMTKHQTRHETMTAAWLLPIVSCIVAAASGGVVASVLPNPDHALITVVTSYVLWGMGVPLALVVLTMYFHRLAIHKLPPSEVIVSVFLPLGPMGQGGYAIMQLGKVAAEIFPQTEILHPMAGEVLYVMGWMVAIVLWGFGLVWLFFAVASIARSRFPFNMGWWGFTFPIGVFTMSTISIGQELPSAFFRILGTVLAISVILLWLVVAVGTAKNILYGNLFEAPCLREMERRANAAAEKGHQNA
The following text describes a protein:
Function:
Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA synthesis (By similarity). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit pol1, an accessory subunit spb70/pol12 and two primase subunits, the catalytic subunit spp1/pri1 and the regulatory subunit spp2/pri2) is recruited to DNA at the replicative forks (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity).
Miscellaneous:
MISCELLANEOUS: The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTVQIDELDDKDLDEIIANGTLDGAKQGAVDSETMIQYYRHLFPWKYLFQWLNHGPVVTNDFAHREFAFTLPNDAYIRYLSFSNWEELKKEALNLCPSRFEVGPVYSANPRDRKTIRKSTFHPLKKELVFDIDMTDYDDVRTCCSKTNICEKCWPFITIAVQVLDICFHEDFGFKHILWVYSGRRGIHAWICDEIACSLDDRSRRMIASYLQVVVGNPQGGVRLINNLKRPLHPHLTRSLNILKSAFVKIVLEDQDPWASKEGAENLLKLLPDKDLASALRKKWEVDPERSSKNKWSDIDTVLASGSIASISPSVIAIAKQDIVLTYLYPRLDVEVSRHLNHLLKSPFCVHPGTSRVCVPIDIERMDSFNPLKVPTVNDLLQELDKNSQNDNGHGPTMETNTTENQKDNARGQSNKGHGFSTSLNPYTLYFKSFSSQLFKETVGNKRKHENLEF
The following text describes a protein:
Function:
May act as a protein phosphatase and/or a lipid phosphatase. Involved in fibrillar adhesion formation. Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition. Enhances RHOA activation in the presence of DLC1. Plays a role in cell polarization and migration. May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton.
Subcellular Localization:
Cell junction, focal adhesion. Cell surface. Cytoplasm, cytoskeleton.
Sequence:
MTWICLSCMLWPEDLEAPKTHHFKVKAFKKVKPCGVCRQAITREGCICKVCSFSCHRKCQAKVAAPCVPPSSHELVPIATESVPKNVVDVGEGDCRGGSTPKNLEEAGSMRVSPSIQPQPQPQPQPISLSRNLSVSRAMEDSCELDLVYITERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSEQRPDITKLHAKVLEFGWPDLHTPALEKICSVCKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKGGCRPFLRIYQAMQPVYTSGIYNIPGDSQASICITIEPGLLLKGDILLKCYHKKFRSPARDVIFRVQFHTCAIHDLGVVFGKEDLDEAFKDDRFPDYGKVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSDPLIRWDSYDNFNGHREDGMEEVVGHTQGPLDGSLYAKVKKKDSLNGSSGPITTARPALSATPNHVEHTLSVSSDSGNSTASTKTDKTDEPVSGAAIAPAALSPQEKKELDRLLSGFGVDREKQGAMYRAQQLRSHPGGGPTVSSPGRHIVPAQVHVNGGALASERETDILDDELPIQDGQSGGSMGTLSSLDGVTNTSEGGYPETLSPLTNGLDKPYPTEPILNGGGYPYESANRVVPVHSSHSAPIRPSYSAQEGLGGYQREGPHPAWSKQVTSAHRGYDPSGLFRSQSFPDVEPQLPQAPARGGSSREAVQRGLNSWQQQQQQQQQQQQQQQQQQQQQPHPPPRQQERSPLQSLACSKPSPHLSAETPIPALPEFPRAASQQEIEQSIETLNMLMLDLEPASAAAPLHKSQSVPGAWPGASPLSSQPLLGSSCQSHPLTQSRSGYIPSGDTLGAPELLSSGRSYSPYDYQLHPAASNQSFRPKSPASSTFLPSPHSSAGPQEPPASLPGLIAEPQLPLKETTSDTSRTPEEEPLNLEGLVAHRVAGVQARERQPAEPPAPLRRRAASDGQYENQSPEATSPRSPGVRSPVQCVSPELALTIALNPGGRPKEPHLHSYKEAFEEMEGTSPSSPPPSVARSPPGLAKTPLSALGLKPHNPADILLHPTGEPRSYVESVARTAVAGPRAQDVEPKSFSAPATHAYGHETPLRNGTPGGSFVSPSPLSTSSPILSADSTSVGSFPSAGSSDQGPRTPIQPMLDSSIRSGSLGQPSPAALSYQSSSPVPVGGSSYSSPDYSLQPFSSSPESQGQPHFSAASVHMVPGSPQARHRTVGTNTPPSPGFGRRAINPTMAAPGSPSLSHRQVMGPSGPGFHGNVVSGHPTSATVAPGSPSLGRHPVGSHQVPGLHSGVVTTPGSPSLGRHPGAHQGNLVSSLHGNAVISPGSPSLGRHLGGSGSVVPGSPSLDRHVAYGGYSTPEDRRPTLSRQSSASGYQAPSTPSFPVSPAYYPGLSSPATSPSPDSAAFRQGSPTPALPEKRRMSVGDRAGSLPNYATINGKVSSSPVANGMASPSGSSTVSFSHTLPDFSKYSMPDNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTITQQGKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSALVYQHSVIPLALPCKLVIPSRDPTDESKDSSGPANSTTDLLKQGAACNVLFINSVDMESLTGPQAISKATSETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWMKTEGGAPAKLFGFVARKQGSTTDNACHLFAELDPNQPASAIVNFVSKVMLSAGQKR
The following text describes a protein:
Function:
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Subcellular Localization:
Lysosome membrane. Note=Localization to lysosomes is amino acid-independent.
Sequence:
MRSVSYVQRVALEFSGSLFPHAICLGDVDNDTLNELVVGDTSGKVSVYKNDDSRPWLTCSCQGMLTCVGVGDVCNKGKNLLVAVSAEGWFHLFDLTPAKVLDASGHHETLIGEEQRPVFKQHIPANTKVMLISDIDGDGCRELVVGYTDRVVRAFRWEELGEGPEHLTGQLVSLKKWMLEGQVDSLSVTLGPLGLPELMVSQPGCAYAILLCTWKKDTGSPPASEGPMDGSRETPAARDVVLHQTSGRIHNKNVSTHLTGNIKQGHGTESSGSGLFALCTLDGTLKLMEEMEEADKLLWSVQVDHQLFALEKLDVTGNGHEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCAGLYACKEGRNSPCLVYVTFNQKIYVYWEVQLERMESTNLVKLLETKPEYHSLLQELGVDPDDLPVTRALLHQTLYHPD
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase that may possess E3 ubiquitin ligase activity in vitro.
Sequence:
MSSSRNTHWCHRCQRAVRLHGQEPVCFYCGGGFVEELDMAQASPFDMFRSHRGVVERDQTFDLMDAFSVFMRNRLAERSHDREIRGRTISSGPENFPGLAPLLIFGGQVPYRLTGDNAVEALFNGGSPGIGITRGNTGDYFFGPGLEELFEQLSAGTTRRGPPPAPRSAIDALPTIKIAQRHLRSSDSNCPVCKDEFELGSEAKQMPCNHIYHSDCIVPWLVQHNSCPVCRQELPSASGPSSSQNRTTPTRNYRSSSSSSSSNSRENGNERRNPFSSFWPFRSSGSSSSSTQNRGGTRNSDTSDENHNYHQQQHQQSYMGYSGWPFDY
The following text describes a protein:
Function:
Involved in maceration and soft-rotting of plant tissue. Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MVRQLALACGLLAAVAVQAAPAEPAHPMVTEAPDASLLHKRATTCTFSGSEGASKVSKSKTACSTIYLSALAVPSGTTLDLKDLNDGTHVIFEGETTFGYEEWEGPLVSVSGTDITVEGASGAVLNGDGSRWWDGEGGNGGKTKPKFFAAHDLTSSTIKSIYIENSPVQVFSIDGATDLTLTDITIDNTDGDTDDLAANTDGFDIGESTDITITGAKVYNQDDCVAINSGENIYFSASVCSGGHGLSIGSVGGRDDNTVKNVTFYDVNVLKSQQAIRIKAIYGDTGSISDITYHEIAFSDATDYGIVIEQNYDDTSKTPTTGVPITDFTLENVIGTCADDDCTEVYIACGSGACSDWSWSSVSVTGGKVSSKCLNVPSGISCDL
The following text describes a protein:
Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAEKEEFERAVDVVTEQEQEYAQKALNEFKKNNYAGALQFINKLDNRTNDFKVAHNKALVEYCKSDFRKNETFQKNLTSICNQFKIRLDKLDDVDQCIVHYNQAILLYHQQQYTNAIYIMDRVYKFIEPMDDALAKQVSLFAIELQLCVRQSDKALSLINYLENQLINGTPNIKLLDKTVKEKDKKAPQPLDPAMEEFKKKLIKYKIRCYLMNHNLEIANKEISNLLKDKQNFQALFLAANLEYLKGNLIESQKLLAAVPPDYLVYNDSGESSTLMFYNNMGVIHHAMGKPNLACHYFQLALKEDIALTNNAKKDKGMDDKPLYALGGSKYHELMYNLGVSLLHAKRPVQAFDCLIIAVRRYHRNARLWMRLAECCIMATKESNEVDFDIQKRQKEIIVNVIGSQDKQKVILTTNVSKDKKYSTESQSYAVPVPSLEFASLCLRNASTLLPSDTVSSPIPLFLIPGGIPPVPSCSPSPAPSSPLSPESVMSLRNSILAASAYVALCLGDYILALEHAENLLQQPRLSGAHKLLGHLYCAEALVLLDKISEALEHLNPENVKHINLELPKGDENEEKRIKTSPPLKWFPHNLPTAIATMQYNFAVAKTIRGQLEDAIGLLKQIWQMSSKCKVPGHIIMLLLYIELKLGRPEPARKLVKQYLFQNRRKHVEIHHSLLRCS