lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus.
Subcellular Localization:
Cytoplasm. Nucleus envelope.
Sequence:
MDSKPSLNLVYAAVSALYNNPNTTEKERASQWLGELQKSVHAWTIADELLHHKRDLESCYFGAQTMRTKIHHSFHELPTEAHESLRNSLLEHISQINEDTNTVIVTQLCLALADLILQMPTWQQAALDLINRFTTTNMWPLLEILTVLPEELESRSVRLGENRRIVMLEDLKSCAGTVNDFLTHCSNTYGNNWQENVQINVKILRCFTSWVSVGAITLNDIANNVVISRAFSILNYKPEGDKPQSVAGSLHDAASDCICTLLQCLEDNNNQQILETYLFNNVINLEIVYHLSVANEDQEKSINYCRIFTELAESFLEKIINSCSTKSFHYAIKVLDLVLICVGHHEYEVAEITFNLWYVLSEELYQKNSKELTELFRPYVERLITALCRHCQMEPDHEGLLEDGDDFKDFRLKVSDLVKDVVFIVGSSSCFRQMFVNLQAPGVTWDSSEAALFIMQAVAKNVLPSENEVVPKVVEAILSLPETTHIAVKYTSVMLLGELCEWIEKHPNTLDPILNFLVCCLPQAGVGAAAAISLQSICATCNDHMPRHVPVLLQLLQQVDTFAITNNAVIGLVKGVAAIVGCMPHCDLTDAMRKLCSMQLNPLCQLIEQDVVPVRGTKSDPVLWLDRLSSVLRNVNVRLYEGQVHPCKPVILEVWPVLSRTFDKYQNDLRIMERCCRSVRFMLRCVSQQVCELLQSLVSQIVRIYATYKHSCFLYVGSILVDEYATDPNCVQGLLDMLQAFIEPTFQLLQEENGLRNHPDTVDDFFRLCSRLMQRAPVPILQCGALVHILQCSLMACTLDHKEANTSVMKFFYDLINTGKCGKNQIDFEQRKVLVTSILNEYGQQLVTNLLHACVFYLHSYMLSEVADVFVELLEFDREATSKWLANGLDTLPKESNGGIMSATPQQLNDIHASMTRSDTSKSVTHALKDLTRFYR
The following text describes a protein:
Function:
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5.
Subcellular Localization:
Nucleus.
Sequence:
MSSDASTYRLEDVLSSFYRVEKIKKINYHQYISKAQNDQWSIQMEFMLRKQDPKTLVALLSRDLWCFSINDDPVPTPPAIEHKPVSPDKIGTFTADYSKPNLPPHYALFLKALRRKIYINLALGSHNKLIQFGNACISLSGVPNYLVQLEPHLFVNGDLTVSLCAKNMGLVPMKEENLEESFLSKHALYLAPSGIRMHLAPASKQGYLITPPKHTELLLTTLSVSHGINLQNKKNLKWVAVVPDLGHLNGHTPTIASYLTPLLEAKKLVWPLHLIFAQPVADIENSTSGDPSEFHCLQDALDAIDDFIQLKQTAAYRTPGSSGVLSSNIAGTNPLSSDGAYTEQFQHYKNNSISSQPASYHSVQETNKISPKDFSPNFTGIDKLMLSPSDQFAPAFLNTPNNNINENELFNDRKQTTVSNDLENSPLKTELEANGRSLEKVNNSVSKTGSVDTLHNKEGTLEQREQNENLPSDKSDSMVDKELFGEDEDEDLFGDSNKSNSTNESNKSISDEITEDMFEMSDEEENNNNKSINKNNKEMHTDLGKDIPFFPSSEKPNIRTMSGTTKRLNGKRKYLDIPIDEMTLPTSPLYMDPGAPLPVETPRDRRKSVFAPLNFNPIIENNVDNKYKSGGKFSFSPLQKEEALNFDISMADLSSSEEEEDEEENGSSDEDLKSLNVRDDMKPSDNISTNTNIHEPQYINYSSIPSLQDSIIKQENFNSVNDANITSNKEGFNSIWKIPQNDIPQTESPLKTVDSSIQPIESNIKMTLEDNNVTSNPSEFTPNMVNSEISNLPKDKSGIPEFTPADPNLSFESSSSLPFLLRHMPLASIPDIFITPTPVVTISEKEQDILDLIAEQVVTDYNILGNLGIPKIAYRGVKDCQEGLITTTMLQLFSTFDRLNGNDTISKFYNMKQPYVFVKKHHELIKVKHDSQPFIKFLNFRPPNGIKNFKSLLLSSSFKEDCLSFAPTLSQTYINQELGFCELLKLTNEDPPGLMYLKAFDKNKLLLLAAQIVSYCSNNKNSIKNVPPILIILPLDNATLTELVDKANIFQVIKNEVCAKMPNIELYLKVIPMDFIRNVLVTVDQYVNVAISIYNMLPPKSVKFTHIAHTLPEKVNFRTMQQQQMQQQQQQQQQQQNNSTGSSSIIYYDSYIHLAYSRSVDKEWVFAALSDSYGQGSMTKTWYVGNSRGKFDDACNQIWNIALNLASKKFGKICLILTRLNGILPDDELMNWRRLSGRNIHLAVVCVDDNSKISFIDEDKLYPSFKPIYKDTRFGGRMDMTRLYDYEIRDIDQDIHGIVFQHPFPLAHSQHRCAIRSGALIKFKKCDGDTVWDKFAVNLLNCPHSDSTQLLETILEEFRNLAALNVWYGLSDGEDGHIPWHILAVKKMMNTLVHTRVKIANTSAATVHTATSSSIILSDK
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSNETRDLYNYQYPSSFSLHEMMNLPTSNPSSYGNLPSQNGFNPSTYSFTDCLQSSPAAYESLLQKTFGLSPSSSEVFNSSIDQEPNRDVTNDVINGGACNETETRVSPSNSSSSEADHPGEDSGKSRRKRELVGEEDQISKKVGKTKKTEVKKQREPRVSFMTKSEVDHLEDGYRWRKYGQKAVKNSPYPRSYYRCTTQKCNVKKRVERSFQDPTVVITTYEGQHNHPIPTNLRGSSAAAAMFSADLMTPRSFAHDMFRTAAYTNGGSVAAALDYGYGQSGYGSVNSNPSSHQVYHQGGEYELLREIFPSIFFKQEP
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MSRRKTVHVPLKLDEEEDRRLAQLLGSDSGSDSSVDESSARPPSSTDNDGAKGRRKPAQSGGGSLRRSSRILSPNTRYVKDYVTGGGRRRGYQEQSDSDTSARDDGADSGGDGRMAGAADDDEEFELLNNKVAATTLFEARTDVAGDGIYGFRTPKKRGSMSALAAQASSAQQQRTPRADPLPGRAPRTPRTPRTPRTAGKVPKTPMHQRQHAKKELSKALQASLMSDFSASESDYEPSEEEEDSDTDEEEEGDQSSEGSCSADIESEYSTASSAGRNRRKSHAATTNGTKAAGAPSTAAPKLAIPVPASLPARGPGRPSRAAASKHSAPPDLQYIVQSDDYFSTFAAGGKSVTSDHTLDRLQTPRLPQDVLLRLLEDTSGTNRAHAAAMQELLDDHSRQFARWLFLLDQGYSVLLYGLGSKRTLLQSFHHRALADRPVLVVNGFFPSLTVKDVLDAVANDLLELQLPTALHHETIDEIERELACQPDLHVFLLVHNLDGVAMRADRMQATLARLASLPNLHLVATIDHINAPLLWDASKLAQYNFCWWDTTTLLPYGVETAFENSLLVQNAGALALSSMASVYASLTSNARGIFMAIVRHQLEQGGPAHPHYPGMPLKDLYWACREAFLVSSDIALRAQLTEFTDHKLLRIKRSLDGSENLHIPIEHGLLKRFVEETAKKV
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MAARQSVIKAVEWGKILERTRPDMKSTIGAFKAKSDGIFNNYVKSKDVKLDIDWAYYQSAVANKALVADFEKQFKAYKVPKPIDTKSKELEDKTAKDNEAVKKFLQETEENLTEVMMTVDRLNSLPPFEQMTIDDIFENFPQVKPDYKKIPHWPHAEIFYVLFSVRAWWHRRKKYTV
The following text describes a protein:
Function:
Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKSLYSRIVVTMLVVILSSSLLGFFFANIYYQIKLKLFNDEKTAKIAKEVQQFYESNATISLNEYLENVGELGYELYLTDGAEKSTYFGGAFRKKDLPDKTIKQVLDGDTYHGIDSFDTGIFITGFFDNDVRNTIGVPVQVDGKQLALFIRQDPEQQFGELRIFFAMILIFTSIISILFVLISGRYIVNPVVKLTNATKKIRKGNYDVAFEVRRKDEIGQLADSFTKMASELEKSEAARQEFVANVSHELQSPLTSMQGFARLLGSGTLTEKEQAEYLTVLSEETTRLSSLTKQLLTLASLDQESELRKKEPVHLAKQWRQLIQMTEWSWREKELTINLDLADVNYTGDAELLYQVWSNLLTNAIKFTPQGGNIQVRLYEDTTNVFVEVQDSGVGISKVDMTKIFDRFYKANESRTREEGSSGLGLSICQKIITLHHGEVTVQSSLEKGTTFTVKLPKN
The following text describes a protein:
Function:
Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth. During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center. Endoplasmic reticulum. Golgi apparatus membrane. Inflammasome. Mitochondrion. Nucleus. Secreted.
Sequence:
MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNAHVSNPTVICREDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMEMLFDPDDEHSEPVHTVVFQGAAGIGKTILARKIMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIVSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQQNEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHRLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRANVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHVVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPGSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGGTFFFSSHSPLQCSTSYVLCHFLVYLLSISAPKI
The following text describes a protein:
Function:
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
Subcellular Localization:
Nucleus.
Sequence:
MRGAGRAGCPPAPTRATCARAVCGGRGRPARDPAPPFLRRRGPAGGGSGPGFGCGPGVVAGAAAGGSAAPSLVVCVGASSPSCCKAFSCRRDSRGPRGGRHQRGIREGGEGGRQCRLLFFCIKIFLICKFYFANILENINFFSPRSPVLPCGVRCAAQPCRPPEVIPPSCLPASLTCARLAGRSLGPGAPPAALGAMSIETLLEAARFLEWQAQQQQRAREEQERLRLEREREQEQKKASSLARLAHALPVEEPRIEAPPLPLSPPAPPPAPPPPLATPTPLTVIPIPVVTNSPQPLPPPLPPAAQPLPLAPRQPALVSTPGLSIKDSAPLPTRPQVPNPAPLLPDSKTTLPPTGSPKPLQPLPTPILTIAPHPGVQTQLAPQQPPPSTLGTLKLAPAEEVKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEKEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASEGEDNIDEDMEEDQAGLGPPKLSHRPHPELPKPPPSTAPAPLPPHPHSHSQPVALSPVHLPGQQPPPQQKTPLPAPPPPPAPAQTLVPAPAHLVAAAGGGSTVIAHTATTHASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAHLGSQLPLYPQPVAVSQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLVGQTVLNPVTMVTMPSFPVSTLKLA
The following text describes a protein:
Function:
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MSAFSESALERKLSELSNSQQSVQTLSLWLIHHRKHSPLIVTVWERELRKAKPNRKLTFLYLANDVIQNSKRKGPEFTKDFAPVIVEAFKHVSSETDESCKKHLGRVLSIWEERSVYENDVLEQLRQALYGEKKPRKRTYDQIKIEDNCSAQSSPGDPPQTADLIRALQELENAACGDAAVHQRIASLPIEVQDVSLLNRITDKDSGEQLSKMVDDACMLLADYNGRLAAEIDDRKQLTRMLSDFLRCQKEVLTEKEQTLEEYKRKLTNVSLVRKELKSRLQSLPDLSRLPNVTGSQVHLPFAGDVYSDN
The following text describes a protein:
Function:
Cationic amino acid transporter which transports L-arginine, L-lysine and, to a lesser extent, L-histidine and ornithine. Plays an essential role in gametogenesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNESNCTKIVNFLKGMRLKTNPNLPGAKQKTPLNIHRFYLLLIIIIYTATSACIYFDWTSIRNLLLNVGKYEHLNISKYADITLSPQYKKINNLYPMTLAIHFTMSVFCGFLYDHIGPKFTAIIGQGFNILSWIFLSIDTTKIDTTLIGFIFLGLGADTAFIPILTVSNLFPDISTFIMTVIGAAASLSYAVPATLNFVYKKYPHFPFYYICYGYIFIILIPCLLVATFLLPMKPFKGLDYYLENDQESDSKNKEQISYTDNDVEMQPSLIQNGNTNVSNNVNKNKATKNIIEGENFHKQSILLFFKVLLSYPSICIIVYFILFNISTVFYGMVTDIYFSYNKSIINIINILMPISFIPCIIFGRFINKYGAAIIIIIMNAFSALMHLTALIKHQAAGLISAFLYMCAASIYTSQIYCFLLNAFPSVVFGKLLGITSLFGGMFSLFCEKLYDNISNSSGNKNDPTTISILLAISFIIMFLPLSILYTRNYEKNIESVNSEKNQIQA
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRASIASLVSYGLLALLSFLALSQVTGTFAQRQAKEQEALFKRIQSSSQGFIDVDTNEFSQIIQVPRDYAVTALLTTTTGGIKCPPCQVFQPEFEKLAQQWNKNKSVKSKNVFIKAEFSRAQGVFARYQLQHAPVLYTFPAPTASNGSPDHVSFDFNERSFSAPDVADHLNKLLNTKFTYKQPLNRKLIIVIATSTIMVAGAIFFIGPHLSGVFTSSKPIWMLLCIGSMIVFNSGYMWNSIRGAPYIAMKAGGKPEYFAGGFQNQYGVETQIVAAIYSLLAFSFIALTVLVPAQRDPTRQRAGVYVWSAIFLATFSLLFFIFRTKNPSYPFRLFF
The following text describes a protein:
Function:
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MYIVETKDLYFRYPDGTAVLKGINFKVKKGEMVSLLGPNGAGKSTLFLHFNGILRPTKGEVLIKGKPIKYDKKSLVEVRKTVGLVFQNPDDQIFAPTVKEDVAFGPLNLGLPKEEVEKRVKEALKAVGMEGFENKPPHHLSGGQKKRVAIAGILAMQPEVIVLDEPTAGLDPVGASKIMKLLYDLNKKGMTIIISTHDVDLVPVYADKVYVMYDGKILKEGTPKEVFSDVETIRKANLRLPRVAHLIEILNKKDNIPIEWGFTIGEVRRNIVNYLKEKC
The following text describes a protein:
Function:
Regulatory transcriptional protein, which trans-activates gene expression from early baculovirus promoters. Can also trans-activate its own promoter, suggesting that it is autoregulated during normal infection of insect cells.
Sequence:
MPKNMETLQRSYMGPSTPNHNLFNNATELPDDLNFSTMDVPYDGSMPMNMSSDSLMNLLEDRSKKLACAVDTELARESTASEFVAGFSADSPQAQLAETGAETGAAGGSKRKASEVDSDSDSDDSSKGKKLVNKPKIRQRYKKATIQNRTSLTEERQYSTEICTVAAPDQIAKYFAQDFSAHLNEVKSECQMSANRFSDYISETGYYVFVVKKGDRKPFEVVFAKFVNNATNEYTNNYYMVDNRVFVVSLNNVKFMVSYKLVREQGIDIPPHVNLCNDAQAERTPLNCYFEPVKNAFQATLINHFHLDMFYAQTTFVTLMQAVGENKTNMLLNKLYQMYQDRSLFTLPIMLSRKEPVNENAPQNKNHAFSYVAQIMKYSKNLRFPQGDPTQQVMDRLEEIVTQKSSLTYKYSSVANLLFNRYGRRDNNADALKKVKKEDGNRLLVEQYMSYNENDDTSHNFIVLQFGGVNDERLTIAKRGKEFYWIAGEIKDISVDDLIKKYARNVHHVFRIINVNRRESTTWHNNLLKLLQLLLQNLIRLEDVQRYSDKSDTKFVYKKV
The following text describes a protein:
Function:
Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity. Promotes testicular germ cell apoptosis. Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1. Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade. In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis.
Subcellular Localization:
Secreted. Nucleus.
Sequence:
MHPARPALWAAALTALTLLRGPPVARAGAGAVGAGPVVRCEPCDARALAQCAPPPTAPACTELVREPGCGCCLTCALREGDACGVYTERCGTGLRCQPRPAEQYPLKALLNGRGFCANASAASNLSAYLPSQPSPGNTTESEEDHNAGSVESQVVPSTHRVTDSKFHPLHSKMEVIIKGQARDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYDTKGKDDVHCLSVQSQ
The following text describes a protein:
Function:
Required for nicotinamide riboside transport across the inner membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSLLESIAVVINLLGVWLTARRIRWCWPVGIVAVALYAWLFYQWKLYSDMLLQGVYVLTQLYGWWQWQRGTALETRIRPLPMPQRELWLSLGVGAGFAAALGAYMHHRTDAALPWLDAALASFSLVASVWAARRRIANWVLWIVLDCVYVGVFVSKALYPTALLYAGFVGLAVYGWHSWNAQRQRTPANAQ
The following text describes a protein:
Function:
May play an important role in lymphopoiesis.
Sequence:
MEGPSLRGPALRLAGLPTQQDCNIQEKIDLEIRMREGIWKLLSLSTQKDQVLHAVKNLMVCNARLMAYTSELQKLEEQIANQTGRCDVKFESKERTACKGKIAISDIRIPLMWKDSDHFSNKERSRRYAIFCLFKMGANVFDTDVVNVDKTITDICFENVTIFNEAGPDFQIKVEVYSCCTEESSITNTPKKLAKKLKTSISKATGKKISSVLQEEDDEMCLLLSSAVFGVKYNLLAHTTLTLESAEDSFKTHNLSINGNEESSFWLPLYGNMCCRLVAQPACMAEDAFAGFLNQQQMVEGLISWRRLYCVLRGGKLYCFYSPEEIEAKVEPALVVPINKETRIRAMDKDAKKRIHNFSVINPVPGQAITQIFAVDNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMSPRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKVLYPASEPLHDEKGKKRQAPLPPSDKLPFSLKSQSNTDQLVKDNWGKTSVSQTSSLDTKLSTLMHHLQKPMAAPRKLLPARRNRLSDGEHTDTKTNFEAKPVPAPRQKSIKDILDPRSWLQAQV
The following text describes a protein:
Function:
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MNSSDFKKSFKESTENNSNTYRPSKTLNTYKSLKNGNNIANSLIIQLNNNVNNNLNKEKLIKSNNNKLLNLNNNNKNNNNNNINNNNNLISKNGILNNIIKNENQNKILKGNNKNNSNSKLDVSKKSISKENVNYLVSGSIAGAISRSATAGFERLTIIQQVQGMSQNLSQGYVGCIAAMKEMVKREGFKSIWKGNGANIVKVSPNSGIRFLTYEFCKKHFLDNSSNHPSSSSIENGIDGNGVGCGSGSEMKMTVPQTMFSGAMAGLTSTFFTYPLDVVRIRLSLQGSCSNDYAAHRYNGITHSFFKIHKDEGVKGLYKGLGTSIASIVPWVSISFATYEGFKIICKKMILNYQISSSSLSTTTTTPSSINNNNNNNNKNNNSFIYENELGENGINLTNTSGCSTMASTMPSSLLINSVASDENELKKGVNMICDFVCGALSGAVTMTVCYPLDVLRRRMMIQGIGGNKVLYKNGWDATKKILSNEGLVAFYHGIIPAYFKVVPTVAISFAVYEICKDLGSNKYQQK
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
Sequence:
KDDVIEVEGSVIESLPNAMFRCTIDGAPDTQEPVLATISGKIRKNYVKILVGDRVTIELSPYDLTRGRITFRKR
The following text describes a protein:
Function:
Sodium-phosphate symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTLPYGLSSVRNHSLLLKTSHLCVPRSALGRFSPKESPLFKKNSALFLSPQKHTSLPLKLVHPLASFSSYAEGDGDQQIQNSHDSDGKGDAEAVGDFSGMANAFHISSKTARAITIVIAFSALSLPLFMKSLGQGLALKTKLLSYATLLFGFYMAWNIGANDVANAMGTSVGSGALTIRQAVITAAVLEFSGALLMGTHVTSTMQKGILMANVFQGKDMLLFAGLLSSLAAAGTWLQVASYFGWPVSTTHCIVGSMVGFGLVYGGAGAVFWSSLAKVASSWVISPLMGALVSFLVYKCIRRFVYSAPNPGQAAATAAPVAVFLGVASISFAAFPLSKIFPIALSQALACGAAGAIIFDRIIRDKLGHLLAKTKPQDTPQNQPKSIGFLSEIAGPTDTQLEIVYGVFGYMQVLSACFMSFAHGGSDVSNAIGPLAAALSILQRGAAGGGGDIVIPMDVLAWGGFGIVAGLTMWGYRVIATIGKKITELTPTRGFAAEFAAASVVLFASKLGLPISATHTLVGAVMGVGFARGLNSVRAETVKEIVASWLVTIPVGGTLAVIYTWVFTKLLSFVL
The following text describes a protein:
Function:
May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Sequence:
MIRDMKFEDSSLTGYLVKNLESLTEADPLILAKYVEALLKKDKPVKELQKLCAENLVEFLGQGTESFITKLFQALEDGSIVVSGENSDAIKQVEPPNSFISEDPIERKISSPNTEGLSPSSCHASDTEEKEFSDDDDDDRNHKHRRRETRSQSFDKYGQEQLLSRPNRKRNKPFENGQLFLEGDPQSSEVRKQYNPTPPERDFSAKFEKRRPSVAALSRPPLDLGQRTKVNPPLRGDPGTRFDLSSVGRLPIGRGRGRSSGPWNQHDSRFSSVDTLDFASQMAPQGPTPGLFPGRGLPNAANTQNASWGAFGLIPGMSNGALDTLHPLGLQGTLRSPSLNIGMPRQRCRDFEERGFCLRGDMCPMEHGVNRIVVEDVQSLSQFNLPVSLPSACLLGMPAGTGPLPSVSAPNLFINSKNSHGKSGKSGAADDGLNLNGVLPVSAGSGEADLYDPDQPLWNTDRPETSSALLKLPSTKIHEAETLWDNDASDCHNLRLADGIDSGRSITTNIGSQSATSSVWGRIRNSGNKLEMSGKNDSTITSTSYFGNEVKDLEEGLPAVPINEHQEKQIVTDDIVPKAMNSSAAAKRSDPARNAGRTSQKASRTLFVNCIPLKNNKREALLSHFQKFGEVIDIYIPVNSEKAFVQFSKREEAEAAVKAPDAVMGNRFIKLWWANRDNIPDDGISSGNTVSAAPRGMTAASTPLLSSIAEIGKENLLSAASKVSASVAPDVPAGASVNPKPVVTNGAKSTAHLQKKLESLELLKEELRIKQEMLDQKRNDFRRQLDKLEKQATTVKPDAVAEQAIKRHKVGPVTPAKIATPRSSNPSTTGTQPTDEKTIDSNNSGDIIASPNSKTGSSVVLQSPRSLKQPSRSLAPVGPPFFVNRFKLDNRPTTFRILPPLPADFANVAVLKEHFSIYGDLSAVELEGSTDTHTGTDGSGPSKNCSARVTFTTRRSAERAFGNGKCWQGHNLQFVWVTLSSNTNSDHGRRENSPAPTPRGIADAEIPTKNVSSACSLSSTGKPTNTVSKEAPAVENEESKDLDGISGSVDCMELVEACQSSSAAMASCEERSPKEDILIVEDDQTVRSEDIGNFNTQLSHSMAEGV
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MVADRPIVVAGAGAIGCFVGGMLAAAGRRVALLVRPRVKTEIERFGLRLTDFDGSEKKLGAGQLALSEDPAIFHSAGIVLVTVKSADTADVADQIAQHAPQDAVIVSLQNGVGNVAVLRERLGGRRVLAGMVPFNVIAMGEGRFHRSTSGDIHVGEDAENTAAALSVPGLSMRASRDITGVQWGKLIINLNNALSALSDMPLAAQLASRNWRKLFAEQMAEGLAAMKAAGINPVSATPIPLNWTPTLLRLPDMIFNAILGRTMKIDPEARSSMWQDLKQGRKTEIDYLQGAVIALAEQSNVNVPLMRRIVALIKEAEVAGNGPPGLTPQQIRG
The following text describes a protein:
Function:
Catalyzes the hydrolysis of guanidine into urea and ammonium. Is highly specific for free guanidine. At pH 8, also catalyzes the release of urea from methylguanidine but with significantly reduced specific activity compared with that for guanidine. Cannot hydrolyze guanidinoacetate, guanidinopropionate, guanidinobutyrate, agmatine, arginine or creatine. Required to use guanidine as the sole nitrogen source for growth. Overexpression of the gene accelerates guanidine degradation and promotes biomass growth.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDATPFRPPSEAEEALIKETRLPLTGWQQEVDQGLTYGLEAAASIKDRSIPTFSRGELPHYAGINTFMKAPYLEDVREVGKYDVAIVGVPHDSGTTYRPGTRFGPQGIRRISALYTPYNFEMGVDLREQISLCDVGDIFTIPANNEKSFDQISKGIAHIFSSGAFPIILGGDHSIGFPTVRGICRHLGDKKVGIIHFDRHVDTQETDLDERMHTCPWFHATNMANAPAKNLVQLGIGGWQVPRQGVKVCRERATNILTVTDITEMSLDAAADFAIARATDGTDCVWISFDIDCIDAGFVPGTGWPEPGGLLPREALYLLKRIIRETNVCGMEVVEVSPPYDISDMTSLMATRVICDTMAHLVVSGQLPRTEKPAYIHAEANMAVDEPWQ
The following text describes a protein:
Function:
Cytochrome subunit of fructose dehydrogenase, an enzyme that catalyzes the oxidation of D-fructose to produce 5-keto-D-fructose. In the complex, mediates both the electron transfer to ubiquinone and the anchoring of the complex to the membrane.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRYFRPLSATAMTTVLLLAGTNVRAQPTEPTPASAHRPSISRGHYLAIAADCAACHTNGRDGQFLAGGYAISSPMGNIYSTNITPSKTHGIGNYTLEQFSKALRHGIRADGAQLYPAMPYDAYNRLTDEDVKSLYAYIMTEVKPVDAPSPKTQLPFPFSIRASLGIWKIAARIEGKPYVFDHTHNDDWNRGRYLVDELAHCGECHTPRNFLLAPNQSAYLAGADIGSWRAPNITNAPQSGIGSWSDQDLFQYLKTGKTAHARAAGPMAEAIEHSLQYLPDADISAIVTYLRSVPAKAESGQTVANFEHAGRPSSYSVANANSRRSNSTLTKTTDGAALYEAVCASCHQSDGKGSKDGYYPSLVGNTTTGQLNPNDLIASILYGVDRTTDNHEILMPAFGPDSLVQPLTDEQIATIADYVLSHFGNAQATVSADAVKQVRAGGKQVPLAKLASPGVMLLLGTGGILGAILVVAGLWWLISRRKKRSA
The following text describes a protein:
Function:
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Contributes only to a minor proportion of PtdEtn production.
Subcellular Localization:
Endoplasmic reticulum membrane; Lipid-anchor.
Domain:
The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.
Sequence:
MGNGNSTETKESRRSKMRKKIQNFRSRRRLSRPGSGSVSGLASQRSVSADDFAGIALLTLIGAEMKFKDKWLACVSFGEQTFRSEISDSTEKPIWNSEKKLLLEKNGPSLARISVFETNRLLKNNIVGYCELDLLDFVVQEPDSTCKSFDLLDPASSNVVGSMFVSCSVEDPVETETCFAKRILSIVDYDEDGKLSFSEFSDLMNAFGNVVAANKKEELFKAADLNGDGVVTIDELAALLAVQQEQEPIINSCPVCGEALQLDKLNAMIHMTLCFDEGTGNQMTGGFLTDRQASYGWMFKLSEWTHLSTYDVGLNTGSSASHIVVIDRKTKRLVEELIDSKIVMSMRAIYQSKIGLRLMDQGAKEILQNLSEKQGKKMNSVESAQNIPSFLEFFKDQINMAEVKYPLDHFKTFNEFFVRELKPGARPIACMDQDDVAVSAADCRLMAFQSVDDSTRFWIKGRKFSIKGLLGNDVQSDAFLDGSLVIFRLAPQDYHRFHSPVSGVIEKFVNVSGSLYTVNPIAVNSKYCNVFTENKRTIVIISTAEFGKVAFVAIGATMVGSISFVRQEGDHVKKGDELGYFSFGGSTVICVFEKDSIKIDEDLLANSARSLETLVTVGMQLGVSFPKLENCVLEP
The following text describes a protein:
Function:
May facilitate PTTG1 nuclear translocation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Note=May be cytoplasmic and nuclear.
Sequence:
MASAVLGLTLRWVMFLSAVLLLLLPGASAQEPPGVGCSEYTNRSCEECLRNVSCLWCNENKACLDYPVRKILPPASLCKLSSARWGVCWVNFEALIITMSVLGGSVLLGITVCCCCCCRRKRSRKPDKSDERAMREQEERRVRQEERRAEMKSRHDEIRKKYGLFKEQNPYEKF