lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MARFGEAVVGRPGSGDGDSDQSRNRQGTPVPASGPAAAYKQSKAQRARTMALYNPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFTNHSGILEGFDPPHPCGVQGCPAGYECRDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGASYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQRTSQLRRHMQMSSQEALNKEEAPPMNPLNPLNPLSPLNPLNAHPSLYRRPRPIEGLALGLGLEKCEEERISRGGSLKGDGGDLDHPRSPLSLGKREPPWLARPCHGNCDPTQQEAGGGETVVTFEDRARHRQSQRRSRHRRVRTEGREPSSASRSRSVSQERSLDEAVPSEGEREREPRGGHGVKEPTIQEEERSQDLRRTNSLMVPRGSGLAGALDEADTPLVLPQPELDVGKDAVLTEQEPEGSSEQALLGDVQLDMGRVISQSEPDLSCVTANTDKAATESTSVTVAIPDVGPLVDSTVVHISNKTDGEASPLKEAEIKEEEEEVEKKQQKKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRQTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKIIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQSESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIIANAKALPYLQQDPVSGLSGRSGYPSMSPLSPQEIFQLACMDPADDGQFQEQQSLEPEVSELKSVQSSNHGIYLASDTQEHAGSGRASSMPRLTVDPQVVTDPSSMRRSFSTIRDKRSNSSWLEEFSMERSSENTYKSRRRSYHSSLRLSAHRLNSDSGHKSDTHRSGGRERGRSKERKHLLSPDVSRCNSEERGTQADWESPERRQSRSPSEGRAQTPSRQGTGSLSESSIPSVSDTSTPRRSRRQLPPVPPKPRPLLSYSSLMRHTGSISPPADGSEGGSPLTSQALEGNDAGLPESSNPRHAPQGQPASPPRYISEPYLALHEDSHASDCGEEETLTFEAAVATSLGRSNTIGSAPPLRHSWQMPNGHYRRRRRGGPGPGMMCGAVSDLLSDTEEDDKC
The following text describes a protein:
Function:
Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity. Promotes myoblast fusion through ELMO/DOCK1.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKAVRNLLIYIFSTYLLVMFGFNSAQDFWCSALVKGVIYGSYSISEMFPKNFTNCTWTLENPDPTKYSIYLKFSKKDFSCSNFSLLAYQFDHFSYEKIQDLLRNNNSIMQLCDTKNAFVFLHYDKNFIQLRRIYPVDFTGLHKREEDDSKSFLEFLVLNKVSPSQFGCHVLCTWLENCLKLENGKTELCGIMYTKCTCPQHLGEWGIDDQSLASLNNVILPLNEQTEGCLTQELQTTQLCNLSKEAKRPPKEEFGMMGDHTIKSQRPRSVHEKKIPQEQADAAKFMAQTGESGVEEWSQWSTCSVTCGQGSQVRTRTCVPPYGTHCSSPLRETRVCNNTALCPVHGVWEEWSPWSLCSFTCGRGQRTRTRSCTPPQYGGRHCEGLEMQHKPCNIALCPVDGLWQEWSAWSQCSVTCSNGTQKRQRECSPASHGGSDCKGPYSETRECHNQECTANGQWNPWGHWSGCSRSCDGGWEKRTRSCQGASITGHQCEGSGEEVRRCNEQRCPAPYEICPEDYLMSMVWKRTPAGDLAFNRCPLNATGTTSRRCSLNLHGVAFWEQPSFARCISAEYRHLQLSIKEHLAKGQRMLAAEGMSQVTKTLLDLTQRKHFYAGDLLISVEILRNVTDTFKRASYIPASDGVQNFFQIVSNLLDEENKEKWEDAQQIYPGSVELMQVIEDFIHIVGMGMMDFQNSYLTTGNVVASIQKLPASSVLTDISFPMRGRKGMVDWARNSEDKVVIPKSIFTPIPSDLDESTVYVLGAVFYKTLGILLPTLRNFTVVNSKIIVVTIHPEPKSTDSLVEIELAHLNNGTLKPYCVLWDEAKSNDSFGTWSTQGCKTVFTDASHTKCLCDRLSTFAILAQQPREIIMESSGTPSVTLIIGCGLSCLALITLAVVYAALWRYIKSERSIILINFCLSIISSNILILVGQTQIHNKGICTMTTAFLHFFFLASFCWVLTEAWQSYMAVTGKIRTRVIRKRFLCLGWGLPALVVAISMGFTKAKGYGTPHYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSRDGILDKKLKHRAGQMSEPHSGLTLKCAKCGVVSTTALSATTASNAMASLWSSCVVLPLLALTWMSAVLAMTDKRSILFQILFAVFDSLQGFVIVMVHCILRREVQDAFRCRLRNCQDPINADSSSSFPNGHAQIMTDFEKDVDIACRSVLHKDIGPCRAATITGTLSRISLNDEEDEKVVKPEGMSYSTLPGNIISKVIIQQPSGLHMPMSMGDITDQCLKKENSDLRRTVYLCTDDTLRAGDTDMGHSQDRMMESDYIVMPRGTGNMQMKDENKMNIAMDTLPHERLLHYKVSPEFSMNPAVMEQFGINLDQHLVSQEHMQSLSFEPRTAVKNFIASELDDSAGLSRSETGSTISMSSLERRKSRYSDLDFEKVMHTRKRHMELFQELNQKFQTLDRFRDIPNTGSLDNPSVNKNPWDSFKNTEYQHYTTINVLDSEAKDTLELRPSEWEKCLNLPLDVQEGDFQTEV
The following text describes a protein:
Function:
Water-repellent structural protein required for surface hydrophobicity and formation of aerial hyphae during filamentous growth. Involved in attachment of hyphae to hydrophobic surfaces. Lep1 and rep1 interact in aerial hyphae to form a strong hydrophobic layer.
Miscellaneous:
MISCELLANEOUS: Regulated by the mating type loci.
Subcellular Localization:
Secreted. Secreted, cell wall.
Sequence:
MPSKIALSISVLTAALGMVSAAPHYEYKSYNAGHNVESVVENKLVDASDLTLGVDILKRTDYSACKKYVSSYNAGYNVYSINENKLIDLSDATVKLSLLTNNGRPVKTWNKAPRYCLEYIKSYNGGHNVIIDNENKLIDLSGLNLGIDILKRKAPEFSYYNPGHNVKSTTENKLVDASDLLANVNILSKRGDKYSYYNGGYNVESDTENKLIDLSGLLANIDILKKRTGSQYSYYNGGHNVESTNENKLVDASDLLANVDILKKRGDKYTYYNGGHNIESTNENKLIDLSDLTANVGVLDDVHVNIGLLDKRTDKYSYYDGGHNIELTNENKLIDLSDLLANVDVLKKRTDKFSYYNGGHNVESDTQNKLIDVSHLTAIVNALSKRTDKYSYYNGGHNVESTNENKLIDLSDLTALVNVLSKRSLKGYGSKIHARDISEELYRRTNADEDCTCVKKSKPTPPKQTVTKPSADCDAPPAVTPKPKPSTKPSPSPTTPPPSKDTSKPTTKPEPKPQPSDKPEPKPSDKPEPKPSDKPEPKPSDKPEPTPSPKPTPPKVTCGTDEVYVDEGHNVVSKNSNKLLDLSNISINIGILDGLFGGKKSKEVAADSTCTSKQGCCVSKSVYYYNGGNNVQSSNENSGIDLSGLNLGLDIL
The following text describes a protein:
Function:
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Nucleus.
Sequence:
MKRHKSDSSFSSKERKDKVGERVSALQQLVSPYGKTDTASVLLETMQYIQFLQEQVKVLSAPYLQTSPTITQEEMVDHSLRSRGLCLVPMEYTLGVAQSNGADIWAPINMAGVMQKFLVASMFMWMLPIAILYAFNHDFLPGSTTLSPHSLTLLSGFLAAVSVNVVIVFYICLALKEPTDKHKPDASFVAEAKDSVKKLTSGVPSTDPALKKQE
The following text describes a protein:
Function:
Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Subcellular Localization:
Mitochondrion.
Sequence:
MSLPRTTRSVRTILSTPSGSIRWAVSCRAISPSSLRALHTSLRREYGKSVIDEASKDEHLLTKRLADELRLPLFSASGEQLHLLEDPSHFYQTLKDKISQAENRIFLASLYIGKEESELIEHLESALCAKPSLQLTILVDALRGTRESAPTPSCASLVSRLRARFPDRVRIRLYHTPNLKGWLKKFVGKRFNEGWGLQHMKIYGFDNDVVLSGANLSRDYFTNRRDRYLMIEDHEDIANYLHSLVQLVGQFSFKLEACEDRGASFEKEESPDWKLIWDGGKDSTSSLRSQTEMQPYRATGWTDEAANAVEEFTRQWNTICPISKAEIAIGRGQADTLLLPLLQMGPLKIRQETCAIPQILELAHKAHDEQGPPPILALTSGYFSLYKPYKALLLQAKAARTAVVKMICAAPEANGFFNSKGVSGWIPEAYTWYEFQFWDALRRSRRLLRQDGKSGEEGGVEIREWKKDGWTYHAKGIWFSPPPAEGSNELAAPTIVHIGSSNYGSRSADLDLECTFLISTLSKKLSQKFKEEWSKLEADAKDRVDESLFQRPDRQVRRRVRIASWILKGML
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPPRIQNVNAAGTGVGAWFESLPPITRTYAASLFIVTLLWRLGFVNVMWIALLWPRVATHFEVWRLVTNFFFMGKFSFNWVIKILWLLSYGTTLERETFAFEPADFLFMMLFGAGCMLGLSLVLLFGLGIPMFFMADSLIFMLLYVWSRQFPQQQVSIYGLFKVLAFHVPFVFVGIEFLMAGAIPYPSLLGIVVGHMHYYLTVLYPAIGGPRLLATPRFLKNLLADAGVGRRVNTHAAPGLDAFRAFGGRGNRLGAN
The following text describes a protein:
Function:
Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere, M line.
Sequence:
QSMSTLHQEEAFEKADQLSLKKTLEETEAFHKKLNEDHLLHAPEPVIKPGTAYKNQVPINVQAHPGKYIIESRYGVHTLEINDDTRFHSGASTLPPSXYASRFEIHFQPEIQXYRNGVPIDAEXXGAPAIPKYNDYIIITXKQPAVDGGSPILGYFIDVGIGXPSRVSEPVAALDPAEKARLKSRPSAPXTGQIIVTEEEPSEEAGTENXQRVNTELPVKXSNNAGVXEPEETGGAEITGYYVNYREVIDGVPGRXREANIKAISDEAYKXEEXTIAVPGPPHMTFKNRARVVGGLPDVVTIQEGKLLASDEHXNLKYGSEISDFTVSVFIPEEEARSVA
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MAPSRKITMNILLFVIAAAAFYSGLLIQRCMDEDSTIRTYPDIGEHAFGKKGRIDKKDSKIAIWTTLVNPPPKYALMVTPIIYSAKNWFPNHCNNGHFDLLLSSSLVISSVVVALAVPFFAYLVSLVGAFLSVSASLLFPCFCYLKISATYRNLGCEMLIIGFIILMGAAVMILGTYTAVSEIIEHL
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MAASGSAQSRRFTTACGVLSRCIKAAEARPVATVVLPLMPGAEVPAQDDHAAGPAPASAQMTIFYGGQVLVLDEVPDDRAAELLRVAAAAGAARGDGDLPMARKASLQRFMEKRKGRVAARAVPYSRPDGDTASCDRVTLTL
The following text describes a protein:
Function:
Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling; May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSRKLSNFILLFLFLVSVSASDNGYSSCNCELEGFFGYKNIMETQRVSDFLIAVAYFSIPIELLYFVSCSNVPFKWVLFQFILFIVLCGMTHLLNGWTYNAHPFQLMLALTIFKFLTALVSFATAITLITLIPLLLKVKVREFMLRKKFWDLGREMGMIKKQKEAGWHVRMLTHEIRKSLDRHTILYTTLDKLSETLDLQNCAIWMPDEAKTVMNLTHQLKGVEQNLTINDFYIPIQDSDVQEIKRSEVVKLLDRESRLSALSSGGLDPPGGVAAIRMPMLRVADFKGGTPEMVQVCYAILVLVLPGGNFRSWTNSELEILKTVADQVAVALSHAAVLEESRLMRDKLVAQNQALQQAKHDAMRASQARRSFQSVMSTGLRKPMHSIMGLLSILQDDNLNDEQRVIIDTMVKNSNVLSILINDVMDDSTKDNGKFPLEMTSFRLHDLVKEAACLAKCLCAYKDNKFEVNFDKYLPHNVLGDERRIFQVILHMVGNLLSWGNGGGCLTFRVFGERGSQSQQWRSWRSKSNDGYVNVKFEIGINDAVSVVERSSGDLRSQRVVAEESLSFTMCKKLVQMMQGNIWVVPNPIEFDQSMSLVLRFQLRPSIMLAGSETSEPSDHHHPLSNSILKGVQVLLADEDDINRAVTSKLLKKLGCVVTTVTNGLNCLTALTPPVAAYQILILDLHLSDLDGFEVASRIRKFRSRNWPLIIASTACGDEDLWERCLEFGMNGILRKPIRMQDIADQLRRVLIQANKVS
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNRGEESLRLMRESGEIKWCPREKSQIAEFYKEKNVLVTGATGFLGKLLVEKLLRACPDLGTIYILVRPKKGEDEHSRVDKLYSDPIFGPLTKLFPKFQHKISIIKGDVSLPDLGLSPSSKSLIYEKINVIFHIAATVRFDEKITVATAINVRGTRDLLNMAKKCQNLQSFVHVSTAYANCVQDEIDEVFYKMPISAHDLIELVETKPEATLIEQTSRIIQNWPNTYTFTKGVAEDAVKNFGKGLPVCVVRPAIVIATYKEPLRSWIDNLYGATGIVVGAGTGLLKTMHCDRSKTAELVPGDYVINNMIAASYKTAVEKITDKIPVYNYVSSVENHHTWNDFMQKCQLWGEEVPTIRCVWYYCLILNKFYWAHFLLSIFLHFLPALIMDLGMVLSRQRPIMVKIYKKITKFESVISHFSTNEWKFHNDNTQALWNSLGEDDRAMFPFSVKELDWDEYHKTHALGLRQYLVKDDISTLPQARIKWRRFYVANKVIKYLVLSVIFYVIYSIFVRFCNY
The following text describes a protein:
Function:
Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTDPRIRQLVIKSGVVRRLTREKYCYAKEVLTEQARLEKLRGDGADDHVLRKQEEVIQECIMMVPDSKRRLQKEYEVLEKYLADEQDLIETDSYKKAAEILKDAKAELET
The following text describes a protein:
Function:
Positive regulator of gsk3/gskA activity required for cell pattern formation and a downstream effector of carC. The kinases, gsk3/gskA, zakA and zak2, form part of a signaling pathway that responds to extracellular cyclic AMP. The pathway has a role in transcriptional regulation; required to direct prespore/spore fates during development. Zak2 negatively regulates prestalk differentiation by regulating expression of ecmA. Phosphorylates Y-214 of gsk3/gskA, in vitro.
Miscellaneous:
MISCELLANEOUS: 'Zaphod' is a fictional ex-president of the galaxy with 2 heads.
Sequence:
MNSHKKEEWEEISSIGSCNSKSRVLKCRKKNGLIENEKVDIVAVKIINKKFFKRNETDILEKIRLFNIPRYYSHAEDDNYIYIYMEYIEDKKQLRFKESEIISMIADLTETLSFLHKHQILHRDIKPSNIILDKNGVLKLIDFGSSIIDQQQDDGDNICKESSFAITGTHTYMAPEVKKLHRSTKKSDVWSLGCTVLEIVGGNPKKIFDGIPIIPNHVSEIMVDFIKRCLIIDPNKRSHMEELLTHRLISSMVGQNKNRENNIEPKFNNDYLSSKFPERFAPRFEKPKWEIEFNELKFNKDDTVGGDGFFSVVKKGYYNETEVAIKLIKKAHGENVTVCDTFYHEVLIISNLRHPNIVQFIAACIKFDNKEVNHCIVSEWMSGGNLSQFISNERKILEINPHLRVKILLDIAKGMLYSHRQGIIHRDLTSNNVLLNFRKKKLLNNNSSNNDEQFYDSDEIIAKVCDFGLSSNQSESKKLRGGSIHYMAPENLNGSPINEKSDIYSFGLLVWQMFSYASPNTIYSPKEMASMVSDEKLNYRPQIPFNVPLKFKELITQCWDRNPLNRPKDFSEIIDKLKDINQIYFQDNSNASTISSTAITTTISTISISNSGNSSYSTSDDSSTYGSGFYNSGFL
The following text describes a protein:
Function:
Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining hspa8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of hspa8/Hsc70: together with dnajb12, acts as a chaperone that promotes maturation of potassium channels by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on hspa8/Hsc70, the process of oligomerization of channel subunits is independent of hspa8/Hsc70.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MESNRDEAERCIAIALGAIKSQNTEKALRFLEKAQRLFPTERAQALYESLSQKSQPENSQSDSTETTNPRLRKNAADSTPSANGEAGGETGKSYTPDQLEAVKRIKQCKDYYEILGVTREATEDDLKKSYRKLALKFHPDKNHAPGATEAFKAIGNAYAVLSNTEKRKQYDQFGEEKVSSSRHGHSDFHRGFEADISPEDLFNMFFGGGFPASNVHVYSNGRMRYTYPQRQDRREHQGDGTLGMFVQLMPILILIIVSALSQMMVSTPPYSLSHRPSVGHIHRRVTEHLKVPYFVTDSFDEEYTGSNLRSVERSVEDDFIANLRNNCWKEKQQKEGLLYRARYFGDSDLYQRAQRMGTPSCSRLTEVQASMHG
The following text describes a protein:
Function:
Uridylyltransferase involved in the biosynthesis of UDP-glucosamine, an essential precursor for glycoprotein and glycolipid synthesis. Can use both UDP-glucosamine and the 4-epimer UDP-galactosamine as substrates, but no other sugars or NTPs. Acts redundantly with GLCNAC1PUT2. Required for gametogenesis and embryo development.
Sequence:
MIEPSMERENGALTAATTTTTAVTSPPPMASSPRQALVERLKDYGQEDIFSLWDELSPDEKDFLVRDIENLDLPRIDRIIRCSLHSQGLPVAAIEPVPENWVSTVDGRTMEDREKWWKMGLKTIYEGKLGVVLLSGGQGTRLGSSDPKGCFNIGLPSGKSLFQIQAERILCVQRLAAQVVSEGPIRPVTIHWYIMTSPFTDEATRKYFSSHKYFGLEPDQISFFQQGTLPCVTKDGKFIMETPFSLAKAPDGNGGVYAALKCSRLLEDMASRGIKYVDCYGVDNVLVRVADPTFLGYFIDKGAASAAKVVRKAYPQEQVGVFVRRGKGGPLTVVEYSELDQSMASAINQRTGRLQYCWSNVCLHMFTLDFLNQVATGLEKDSVYHLAEKKIPSMNGYTMGLKLEQFIFDSFPYAPSTALFEVLREEEFAPVKNVNGSNFDTPESARLLVLRLHTRWVIAAGGFLTHSVPLYATGVEVSPLCSYAGENLEAICRGRTFHAPCEISL
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKLPPPPVQSSPQGFQLPSLHSVQLKPVRPPPQPTQQQLASNTSPREVGTSLSPQSPSNNINPSSSSSSPSSSIRQSPSSSPNVARKVPPTPTNNNGGPPTTTTTTTTTMPPPPAFIKKLSPSSSPILPKRIVSSPPLNGNTAPPPPPIVHLPPPPPTNLPPPPTLSPSSSTTTSPSSSSLNLSGGVPLPPRILRNSDGSANNNNNSNNNSNNNINSLNLSTSGGIPPPPSFFNNNNNNNNNSGSFVNSASSNGSPSLQSQNSVGYFKPPPPPVPTRSASLDPKQMGQFIKPQQNQNNSNNINNINNNNNNIILPPPPNININNNNFVPYIPSNNNQQQSTTPPPIVSISPLKRNSIDNSVVNKRLSQDLNTMLVNRLQHGLSPPVATPFFDDKILGSASKSAELKEKRDQEERERRERERIKKEKEDSEKKEKKEKKGKEEQEKKDKKKKEEQEKKDKKKKEEEEKKSKSSSSSSSSSKKSSSDNTIVNQNIFNNTLSQIMENQRDAQSLSPSSLPYPLILKLLTESIMSLNGPYTEGIFRITGSGTEVNRLKKQINEHDFSLDTQDPHVLAGLLKLWLRELVHPIIPSELYNDAIKSRSKEEVSRIISLIPDQNKEVLNFLIPFLKNVSQPHYAQYSKMDIDNVAMVFSPGLLRSTVLTTDLLLNSQYEKDFVKCLIEMSP
The following text describes a protein:
Function:
Inhibits the establishment of the immune response and of the integrated stress response (ISR) in the infected cell (By similarity). Plays essential roles in viral nuclear egress to mediate capsid transit across the nuclear membrane. Facilitates nuclear egress cooperatively with host C1QBP and protein kinase C/PKC to induce lamin A/C phosphorylation and subsequent reorganization. In turn, lamina disassembles and nuclear egress occurs. Recruits the serine/threonine protein phosphatase PPP1CA/PP1-alpha to dephosphorylate the translation initiation factor EIF2S1/eIF-2alpha, thereby couteracting the host shutoff of protein synthesis involving double-stranded RNA-dependent protein kinase EIF2AK2/PKR (By similarity). In turn, controls host IRF3 activation and subsequently inhibits host interferon response. Controls the DNA sensing pathway by interacting with and inhibiting host STING/TMEM173. Also down-modulates the host MHC class II proteins cell surface expression (By similarity). Acts as a neurovirulence factor that has a profound effect on the growth of the virus in central nervous system tissue, by interacting with host BECN1 and thereby antagonizing the host autophagy response.
Miscellaneous:
MISCELLANEOUS: ICP34.5 is detected as early as 3 hpi prior to viral replication but reaches maximal levels late in infection. ICP34.5 gene is therefore classified as gamma-1 or leaky late gene; MISCELLANEOUS: The phosphatase activity of the ICP34.5-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, which inhibits viral replication.
Subcellular Localization:
Host cytoplasm. Host nucleus. Host nucleus, host nucleolus. Virion. Note=At early times in infection, colocalizes with PCNA and replication proteins in the host cell nucleus, before accumulating in the host cytoplasm by 8 to 12 hours post-infection.
Domain:
The triplet repeats region may play a role in modulating virus egress.
Sequence:
MARRRRHRGPRRPRPPGPTGAVPTAQSQVTSTPNSEPAVRSAPAAAPPPPPAGGPPPSCSLLLRQWLHVPESASDDDDDDDWPDSPPPEPAPEARPTAAAPRPRPPPPGVGPGGGADPSHPPSRPFRLPPRLALRLRVTAEHLARLRLRRAGGEGAPEPPATPATPATPATPATPARVRFSPHVRVRHLVVWASAARLARRGSWARERADRARFRRRVAEAEAVIGPCLGPEARARALARGAGPANSV
The following text describes a protein:
Function:
Has antibacterial activity.
Subcellular Localization:
Secreted.
Sequence:
MPGAMRIFFLIFAALILAQIFSVRGGVGRQLRCLKLDGRCEVECLSFEVQIGGCRAELTPLCCKKRKNH
The following text describes a protein:
Function:
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
Sequence:
MSSGDTELRKRIEFIIFGGTGDLSRNKLIPAILKLKDKIDLKKIYILGRNRKKFEEIKEKFKDFSELFVFVEFLAEREESYKNISSILGKESLKVFYLAVPPDLFKEILENVGKYLNFPEKRIVIEKPFGLSLKHAKDLNKIISVYFKEEEIFRIDHYLGKPQVQNILAFKFSNYVFSEVLNKCLVEKVEVIALEEVGVEGRKAYYEKVGVIRDMLQNHMLLLSSLIVMRLPPRAEDFHFELKNALKRAEFESESLILGKYKSYQGKAPTFALVKLHFDDERFTGVPFVLATGKKLKKKLTRVCIHFKNFPKEIERLLGCVPERNLLVFELYPEQEVSFRVNVISPLGFLRCTESINWRVSLKDVLGEIPEAYESLLLDVIRGDKTLFLDAEETEILWEKTEPLLKKEKEVLTYDDRVLIPEFAEDFISCL
The following text describes a protein:
Function:
PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.
Subcellular Localization:
Secreted. Host cell membrane.
Sequence:
MPIDRKTLCHLLSVLPLALLGSHVARASTPGIVIPPQEQITQHGGPYGRCANKTRALTVAELRGSGDLQEYLRHVTRGWSIFALYDGTYLGGEYGGVIKDGTPGGAFDLKTTFCIMTTRNTGQPATDHYYSNVTATRLLSSTNSRLCAVFVRSGQPVIGACTSPYDGKYWSMYSRLRKMLYLIYVAGISVRVHVSKEEQYYDYEDATFETYALTGISICNPGSSLC
The following text describes a protein:
Function:
Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Also plays a role in mitophagy and regulation of filamentous growth (By similarity).
Subcellular Localization:
Preautophagosomal structure. Note=Also localizes to other perivacuolar punctate structures.
Sequence:
MNSKNTIVYVKVPGRQREGFVDPPPFEWNQHQDRKLWAHISTIEDKDDIDWQLLSNQTNAPEFFIRKRVYQLFRVHLKSIEQEIYSHTSADRAPNRSSQAGDEPAASVGVLNGYGQNINDIHDLSSLQTPPTCRGKANKDEDGGNSSGISELSSLSVSKSALEEALMDRLQL
The following text describes a protein:
Function:
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways.
Sequence:
MAAAVPVIKIAALSGSLRKASFNSGLIRSAIELSKESVNGIQIEEIDISQLPLLNADLIVDGTYPPVVEAFRQKIIKADSVLFASPENNYSLSAPLKNAMDWASLPPNCWGDKTAAVVSAGGGFGGGRSHYHLRQIGVYLDLHFINKPEFFLNAFQSPAKFDDDGNLIDAETKERLKEILVALRDFTLRLHK
The following text describes a protein:
Function:
May transport inorganic phosphate (Pi).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDRLLLLSSCTLLRQFHSGKRILKYFISCLIVFLTMFASEWRVKYCDYKQLKKVVKRIKNQILHTKNQQHKVFDPNVFSVDKSKLQNLLQNPSAILSSCCEQSISSETSMVVHKTRTGDGEDFYETELFGTRSDHEKSFFFGLDDQLNKVDKFFRCKEDEYDAQAQQLHIQMEELIAMQDDESQSLKGSPGNKGKVQRAAKMLQTAFVEFYRGLRLLRNFSSLNMMAFVKILKKFDKVTGQNASGSYLKMVENSHFATSDKVVKFMDRVERVFTLHFTKGNRKQAMAYLRPIHSASNHGNINFILGLFSGCSWSLLAAFVLILVLGNKDGITTKYIQAVFPVFSTLFLFVLHLYMYGWNIYVWKQVRINYTFIFEFSPKQELRHQDVLLLSTGLTTLIIIGMIFHLATYTVTHVDSEIIALVVFLLLILLLICPLDICYKSSRAAFLRCTWRIISSPLFKVVFADFFLADQLTSQVPALRNLGYISCYYGGGFFRTRNTGACTKSTLFKSFQYLISVLPYWWRLMQCWRRWMDEHDTAHIANGGKYLSALIAVVVRLTYSRIKSEFWLGIFVISSIFATVYQLYWDIVVDWGLLQPKSFNPWLRDQLILKRKITYFLSMEMQALNVILRLAWIYSVTHPPGTEIELMIIDLFFAALEVIRRGHWNFYRLENEHLNNVGRYRAVRAVPLPFKQMDDTLA
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The precise function of this subunit is unknown but believed to be important.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=The import of this subunit is dependent on proteinaceous components of the mitochondrial outer membrane.
Sequence:
MPITPTKYAITTRQSANWSDAKRRVFALYRRWLRSTPEMQSMYSLPLPISVIRTRIRQEFERNRFVNKLPVVDVLLTKGHADYQETMNFWRQTTHMMSYFNEESFRGAKRLPSSFIDGFLQGRN
The following text describes a protein:
Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
Sequence:
MRNIGNGNLLLTAAGGVGKLRFTINPTHPRLSRLLIAGQQSRASIHSTTTTTTTTTIAKTIAKTTPHHRHNHHRKMASPAEDQATHHQDLADRASRSNRGGRGGRGPKSGGHGGGHRKGGGRDVDLSRALSRLLRHQAASAGITLDAEGYAPLDKVLAWGPIRSLKPTFPEILKAVKESDKQRFAIKLAPGKEKEDGEKSEEPGDWLIRANQGHSIKLESEGLLRRLVLGRGGGGGQQQQQQQGQETEGEDGGTIPIPETVVHGTYFAFWDKIIQSGGLKPMGRNHVHFSTGLPEDTERGVISGMRSDAEVLVFVDVERSIRDAEEAEKEDKEGKGIKWWMSDNGVVLTEGDKDGLVPLKYFKEVRGRRQGVGLLWKDGHKVADLPEGLEIRMPMGKGRAAGGGGGGGGKRGGRGGGERKDSGKGGRGREEKGNGEEAKPLEMDSQ
The following text describes a protein:
Function:
Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MAPWPLTFLLFLLLLLWLQGCDSGSSSEKLYRKVQRREGETLSVQCSYKNRRNLVEAKSWCKVKRKKCEHSFTRSWVRGPSYSMRDDTKAKVVRITMEALRVQDSGRYWCMRNTAGNLYPLVGFQLEVYPALTTERNVPPTHLTNTLKDGFANTPMDEFVTTSQVHMSDTGDPFTTNVTVFSSGLHTLASGTTAPTPVTRYSFADTSGTITETERSTESQPATVSPSHTRPFLADSVTTSTMTRHQSSSLSTTGTCHQLTPNRSQETHRPVMVVVLTFLPAPMLLVVAYGFWKKRHMGRYNLDSNYAKSWLHLPEGPETLWKPACSKITQ
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of plastid-encoded RNA polymerase (PEP) to specific initiation sites and are then released.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MNSSRSLLSSPLFASSSPNFRSSASVSSSPSPSRTTAVPMIHDTSSSRASTACHYSPSLVAEEQLHGSKDTLTLKGEKALLELLLGMALDQHVDGRKLITQQEAEDSDFESYLREATSRVLYQPTFISEEDDDDDSVSESSSASLAKPAGTLDLGKLTEEPQLDVPQPHRRSVDPNHSYDQVFIRSTRLLERRSKKRNGGHRALDNGVACSGVNSKRKDKFGRVLDPDEPFRLFLRDRETTEFLTAKEEKQMFSQIQNLMKLEGAQRNLQAQCGREPTVEEWAQAVGMSCRELQSCVRTGRRCREKMARSNFRLVIHVARKYEGCGLDIQDLVQDGCCGLMKTFEKFNPSKGCRFPTYAYWWIRQSIKKSIFKNSRLIRLPESVYALLRKVGKARMECIMDGEQPTNEVVARRAGITIEKLAKLRAKTRKVRSMQDRVWSDDGVTYQEITEDPNIEGPEVSVDRLMMRQQVRSFLTGILSPREKEIIEHRFGIHDGQPKTLHVIGDMYGLSKERIRQVQNKALDKLRNSISAQGFHVYFDLLT