lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine, and transiently retains the released sulfur atom on a cysteine residue, in the form of a persulfide. Can also desulfinate L-cysteine sulfinate (3-sulfino-L-alanine), which is the best substrate of the enzyme. Functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. Seems to participate in Fe/S biogenesis by recruiting the SufBCD-SufE proteins. Transfers sulfur to CsdE that increases the cysteine desulfurase activity of CsdA. Can also transfer sulfur directly to TcdA/CsdL in vitro. Appears to support the function of TcdA in the generation of cyclic threonylcarbamoyladenosine at position 37 (ct(6)A37) in tRNAs that read codons beginning with adenine.
Sequence:
MNVFNPAQFRAQFPALQDAGVYLDSAATALKPEAVVEATQQFYSLSAGNVHRSQFAEAQRLTARYEAAREKVAQLLNAPDDKTIVWTRGTTESINMVAQCYARPRLQPGDEIIVSVAEHHANLVPWLMVAQQTGAKVVKLPLNAQRLPDVDLLPELITPRSRILALGQMSNVTGGCPDLARAITFAHSAGMVVMVDGAQGAVHFPADVQQLDIDFYAFSGHKLYGPTGIGVLYGKSELLEAMSPWLGGGKMVHEVSFDGFTTQSAPWKLEAGTPNVAGVIGLSAALEWLADYDINQAESWSRSLATLAEDALAKRPGFRSFRCQDSSLLAFDFAGVHHSDMVTLLAEYGIALRAGQHCAQPLLAELGVTGTLRASFAPYNTKSDVDALVNAVDRALELLVD
The following text describes a protein:
Function:
Plays an important role in regulating the size of autophagosomes during the formation process.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MEVRKLSISWQFLIVLVLILQILSALDFDPYKVLGVSRTASQADIKKAYKKLAREWHPDKNKDPGAEDKFIQISKAYEILSNEEKRSNYDQYGDAGENQGYQKQQQQREYRFRHFHENFYFDESFFHFPFNSERRDSIDEKYLLHFSHYVNEVVPDSFKKPYLIKITSDWCFSCIHIEPVWKEVVQELEELGVGIGVVHAGYERRLAHHLGAHSTPSILGIINGKISFFRNAVVRENLRQFVESLLPGNLVEKVTGKNYVRFLSGWQQENKPHVLLFDQTPIVPLLYKLTAFAYKDYLSFGYVYVGLRGTEEMTRRYNINIYAPTLLVFKEHINKPADVIQARGMKKQIIDDFITQNKHLLAARLTSQKLFHELCPVRRSHRQRKYCVVLLTAETTKLSKPFEAFLSFALANTQDTVRFVHVYSNRQQEFAGTLLPDGEAFQGKSAVSILERRNTAGRVVYKTLEDPWTGSESDKFILLGYLDQLRKDPALLSSEAVLPDLTDELAPVFLLRWFYSACDYISDCWDSIFHNNWREMMPLLSLIFSALFILFGTVIVQAFSDSSDERESSPPDKEEAQEKTGKTEPSFTKENSSKIPKKGFVEVTELTDVTYTSNLVRLRPGHMNVVLILSNSTKTSLLQKFALEVYTFTGSSCLHFSFLSLDKHREWLEYLLEFAQDAAPIPNQYDKHFMERDYTGYVLALNGHKKYFCLFKPQKTVEEEEAIGSCSDVDSSLYLGESRGKPSCGLGSRPIKGKLSKLSLWMERLLEGSLQRFYIPSWPELD
The following text describes a protein:
Function:
Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex.
Miscellaneous:
MISCELLANEOUS: Present with 2170 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSSRDASLTPLKAVVIDDPPLRQTPEPFDEQSAYNPQSPIAIDFGSSKLRAGFVNHATPTHIFPNALTKFRDRKLNKNFTFVGNDTLLDQAVRSQSRSPFDGPFVTNWNLTEEILDYTFHHLGVVPDNGIPNPILLTERLATVQSQRTNWYQILFETYNVPGVTFGIDSLFSFYNYNPSGNKTGLVISCGHEDTNVIPVVDGAGILTDAKRINWGGHQAVDYLNDLMALKYPYFPTKMSYLQYETMYKDYCYVSRNYDEDIEKILTLENLDTNDVVVEAPFTEVLQPQKTEEELRIQAEKRKETGKRLQEQARLKRMEKLVQKQEEFEYFSKVRDQLIDEPKKKVLSVLQNAGFDDERDFKKYLHSLEQSLKKAQMVEAEDDSHLDEMNEDKTAQKFDLLDIADEDLNEDQIKEKRKQRFLKASQDARQKAKEEKERVAKEEEEKKLKEQQWRETDLNGWIKDKRLKLNKLIKRRKEKLKLRDEMKDRKSQVSQNRMKNLASLAEDNVKQGAKRNRHQATIDNDPNDTFGANDEDWLIYTDITQNPEAFEEALEYEYKDIVELERLLLEHDPNFTEEDTLEAQYDWRNSILHLFLRGPRPHDSENIHEQHQMHLNVERIRVPEVIFQPTMGGQDQAGICELSETILLKKFGSQPGKLSQTSIDMVNNVLITGGNAKVPGLKERIVKEFTGFLPTGTNITVNMSSDPSLDAWKGMAALARNEEQYRKTVISKKEYEEYGPEYIKEHKLGNTKYFED
The following text describes a protein:
Function:
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
Subcellular Localization:
Nucleus.
Sequence:
MSLPGLELSQTSSEREFVPAPPTQITLSKGSEWRFEVAFGTAIRVKLLAGTAELFGTELAASQTYTFSGTKAAIYTWHGCTLEVSAGDTISTIDGLGSGGLNGEGARGYGAGGCQSEYTAEETPMVEYANVHFALEAMRQEAKATGKDGPRVLILGPENAGKTSVAKILTAYATKVGRQPIVVNLDPAEGMLSVPGTLTATAFRTMMNVEEGWGSSPMSGPSAVPVKLPLVYFYPLQNPLEAEGAVYRPIVSRLALSVTGRMAEDEDTRETGIIVDTPGILSAGKPGSLEIINHIVTEFASSERLYSTMMKNYDNKPTSSASAAASDERITVVKLSKSGGCVDRDAAFMKSVRESQIRTYFFGNPIPSTASAALSMSASSTTNITLSPHAQQLDFDSLAVYNYTIASSDEDEDEYDPSQFGASDTFLPGGRNDAEGPETKHAEETSFTSSVPGLGGSSGDDAASGSSAVPLKKVLPPAPNTLANSLLAVTHTAPNASPAEIRDASIMGFLYVADVDSEKGKIRVLAPIGGRVPPRAIVWGKKWPGEVVGLVG
The following text describes a protein:
Function:
Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity). Plays a role in meiosis and sporulation.
Subcellular Localization:
Cytoplasm. Nucleus. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MTGLVDQQELEKRLATEEDSQNEDIENQLPSIETIINTYREKENRRVNLRFKAIGRTPLLRKTVFSINASQRFEKVTRFLKKELGLPMNSSLVLYVNSSFAPSPDEIVGNLYDNFAIDSHLLINYCINVAFG
The following text describes a protein:
Function:
Active against glucose, fructose, mannose, maltose and galactose.
Sequence:
MLGLLTITSVFRNWRNSLQRKEDYDECHMRGINNENEISGKSEKNFKLDEPPISLETVMAEFKLSNETLRRMMAHMSRNMDKGLEGGPENSTISMLPSFVPELPNGTEEGRFIAMDLGGTNLRVMLMDIKPGEELKTEQFNTRIPNWAMRGTGEQLFDYITKCLAEFLIEKGIENDGLPVGFTFSYPCDQKSLRSATLLRWTKGFETTGVVGEDVVELLEQSIARRGDIKVEVVALINDTVGTMVAAAHESGGECHIGVIIATGTNASYMEDTSKIKYGLSKAIAAYNYPEMIIDTEWGGFGDRSEADYILTQYDKIVDSRSEHPGVNTFDKLVGGKCMGEVVRVVLEKLTRARVLFNGKGSDALFQQDSFPTKYISEILRDESGSYVHTRDILGELGIDHYSFSDMLLLREVCVVVSRRSANLGAAAIACVLNRVRKQNMVVGIDGSTYKYHPFFDFWVHDKLKELVDPGLKFKLLQTADGSGKGAALITAIVARLKKRNLKQQQQQQQQQQQHVTMVEQNVVEQIAETKGSREQFMNGNQKINLVTNDIPIYDSFNGDIENGVIHLSTDH
The following text describes a protein:
Function:
Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNNPPPMMGYQPSGGGSVTQMLGTPQPLAQPLHQTGPTQQAQQMLQQPPGLVSSGTRQMLGQIGQVGSNPLCHPHQSDPTLVNNPIWKLQLQLAAISRQSVGQANVYARQNAMKKYLMTQTNGSQQPADMAKSLVDFTKQYLLEMAADPAVPNNAALAASGQQIQRPHGTPVSTPSTPKAELANNAQTTPSILLQQQQKKLSQFNIDEDDEVEHRMMAPVNTKYDEQLWHTIDLSNLSVYNLNENLFKYDFLTRLYLNGNNLTHLPASIKQLQNLRVLDVSHNRLTELPPELGMCYQLKYLYFFDNMVSTLPWEFGNLFNLQFLGCEGNPLDRQLIKILTEKSVTGLIFYLRDNAPEIPLPEPRRFIEVNADGESVETYRCIEESTNHLNEELLKKSFTLLSYNTLCQHYATPKMYRFVPSWALSWDYRREKLKDEVLAYQTDIICLQEVESKTYEEFWLPILEKQGYSGIFHAKTRARTMQSKDAKKVDGCCIFYKNSEFTAVFKDAIDFSSVWMKHKKFQRTEDYLNRAMNKDNVALIIKLRHERTGEHVWVVTTHLHWDPHFNDVKTFQVAVMLDYIEKLLKQHGGVGSPQDKKKIPLVICGDFNSQLDSAVVELFNTGSVRSHKDIEGRDFGYMSQKNFAHGLALKSSYGSIGELPFTNLSPTFTDVIDYIWYSTQALRVRGLLGEIDPAYAAKFIGLPNDKIPSDHIPLLARFEFTKGSSATINTNGNKTV
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Miscellaneous:
MISCELLANEOUS: Present with 8070 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDLKTSYKGISLNPIYAGSSAVATVSENGKILATPVLDEINIIDLTPGSRKILHKISNEDEQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYILDADSTSTLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWKDCTEQEIEEEQEKAKLQVEQEQSLQNYMSKGDWTNAFLLAMTLDHPMRLFNVLKRALGESRSRQDTEEGKIEVIFNEELDQAISILNDEQLILLMKRCRDWNTNAKTHTIAQRTIRCILMHHNIAKLSEIPGMVKIVDAIIPYTQRHFTRVDNLVEQSYILDYALVEMDKLF
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
Subcellular Localization:
Nucleus.
Domain:
Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors; The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.
Sequence:
MADAAASPVGKRLLLLFADTAASSSASVPAAAAAGGDPGPALRTRAWRAGTVRAMSGAVPQDLAIFVEFDGCNWKEHSWVKVHAEEVIVLLLEGSLVWAPRKDPVLVQGTRVSIAQWPALTFTPLVDKLGLGSVVPVEYLLDRELRFLSDANGLHLFQMGTDSQNQILLEHAALRETVNALISDQKLQEIFSRGPYSVQGHRVKVYQPEGEESWLCGVVSHQDSITRLMEVSVTESGEIKSVDPRLIHVMLVDNSTPQSEGATLKAVKSAKGKKKRESIEGKDGRRRKSASDPGCDPASKKLKGDRGEVDSNGSDGGEPSRGPWKGGSASGEPGLDQRAKQPPTTFVPQINHNIRFATYTKENGRTLVVQDEPVGGDTPVPFTPYSTAASQTPMAPEVGGAENKEAGKTLEQVGQGMVASAAVVTTASSTPTTVRISDSGLAAGTGPEKQKGSWSQAPGENSRNSVLTSSGFGASLPSSSQTLTFGSGRSQSNGVLATENKPLGFSFGCSSAPESQKDSDLSKNLFFQCMSQTLPTSNYFTTVSESLADDSSSRDSFKQSLESLCKGRSTLGADTKSGSKAGSSVDRKVPAESMPTLTPAFPRSLLNARTPDGHENLFLQPPKLSREEPSNPFLAFVEKVEHSPFSSFASQASGSSSSATTVTSKAAPSWPESHSSTDSASLAKKKTLFITTDSSKLVSGVLGSLTTGGPSLSAMGNGRSSSPTSSLTQPIEMPTLSSSPTEERPTVGPGQQDNPLLKTFSNVFGRHSGSFLSSPADFSQENKAPFEAVKRFSLDERSLACRQDSDSSTNSDLSDLSDSEEQLQAKTGLKGIPEHLMGKLGPNGERSAELLLGKGKGKQAPKGRPRTAPLKVGQSVLKDVSKVKKLKQSGEPFLQDGSCINVAPHLHKCRECRLERYRKFKEQEQDDSTVACRFFHFRRLIFTRKGVLRVEGFLSPQQSDPDAMNLWIPSSSLAEGIDLETSKYILANVGDQFCQLVMSEKEAMMMVEPHQKVAWKRAVRGVREMCDVCETTLFNIHWVCRKCGFGVCLDCYRLRKSRPRSETEEMGDEEVFSWLKCAKGQSHEPENLMPTQIIPGTALYNIGDMVHAARGKWGIKANCPCISRQNKSVLRPAVTNGMSQLPIINPSASSGNESTFSGGGGTASVTQPETDHVPKADSTDIRSDEPLKADSSASHSNSELKATRPPCPDAAPPSSALHWLADLATQKAKEETKEAGSLRSVLSKESHSPFGLDSFNSTAKVSPLTPKLFNSLLLGPTASNNKTEGSSLRDLLHSGPGKLPQTPLDTGIPFPPVFSTSSAGVKNKASLPNFLDHIIASVVENKKTSDAAKRACNLTDTQKEVKEMVMGLNVLDPHTSHSWLCDGRLLCLHDPSNKNNWKIFRECWKQGQPVLVSGVHKKLKSELWKPEAFSQEFGDQDVDLVNCRNCAIISDVKVRDFWDGFEIICKRLRSEDGQPMVLKLKDWPPGEDFRDMMPTRFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGLITAEDRRVGTTNLHLDVSDAVNVMVYVGIPIGEGAHDEEVLKTIDEGDADEVTKQRIHDGKEKPGALWHIYAAKDAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQTLRKRLYEEYGVQGWAIVQFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFRHLSNTHTNHEDKLQVKNIIYHAVKDAVGTLKAHESKLARS
The following text describes a protein:
Function:
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
Subcellular Localization:
Cytoplasm.
Sequence:
MASSTQHTVQPSVDDDDLKPSQTAGYNPGVAKTLEEYANLDAQDESLRKWKESLGIVPGGSTGKPTLSICSLSLHSPELSKPIVMDLTDPELLQKYKKEPLTIKEGAEYSVEIAFKVEGGVISGVKYLQVVKRAGVKLDKLESMIGSYGPSSDLHVKRFVSEEAPSGMLARSGSYTARSRVIDDDGTVWADFEWSFKIGKEW
The following text describes a protein:
Function:
Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and glutarate, succinate, adipate/hexanedioate, itaconate and 3-hydroxy-3-methylglutarate as dicarboxylate acceptors. Acts on intermediates or end products of lysine and tryptophan degradation pathway, in particular catalyzes succinyl-CoA-dependent reesterification of free glutarate into glutaryl-CoA to prevent renal excretion of glutarate. Upon inflammation, may convert macrophage-derived itaconate to itaconyl-CoA in erythroid precursors where it negatively regulates the TCA cycle and heme synthesis to limit erythroid differentiation in the context of stress erythropoiesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MPSEAHAMLATLARVAAXXXXXXXRGGGRGLWTGRPQSDMNNIKPLEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGSGDDTRTWGPPFVGTESTYYLSVNRNKKSIAVNIKDPKGVKIIKELAAVCDVFVENYVPGKLSAMGLGYEDIDEIAPHIIYCSITGYGQTGPISQRAGYDAVASAVSGLMHITGPENGDPVRPGVAMTDLATGLYAYGAIMAGLIQKYKTGKGLFIDCNLLSSQVACLSHIAANYLIGQKEAKRWGTAHGSIVPYQAFKTKDGYIVVGAGNNQQFATVCKILDLPELIDNSKYKTNHLRVHNRKELIKILSERFEEELTSKWLHLFEGSGVPYGPINNMKNVFAEPQVLHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQHTTHILKEVLRYDDRAIGELLSAGVVDQHETH
The following text describes a protein:
Function:
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKRWFITGTDTDVGKTVASCALLQAATAQGYRTAGYKPVASGSQMTADGLRNSDALALQANSSQRLGYSQVNPFTFLEATSPHIASESEGRAIPLTALSQGLRQLEPSADWILIEGAGGWFTPLSPQATFADWVQQEQLPVIMVVGVKLGCINHALLTAQAIQHAGLTLAGWVANEVTPAGRRQAEYQATLTRMITAPLLGIIPYLSDIEENPVTTRRDLGHYLDLTVLRAAEREAVNM
The following text describes a protein:
Function:
Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis.
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MIDRQRIFRAGRGKIPNGWRDSLQVSLGGLELINKVVDLCSCGHLWIILQAALWTRVDRCVPITLGWTKGKIGSSSHSLDHIGLLIWVPASPCQKTLYGQMKVYAKFDQNVYLPKDAEFYFIYNGSRQRHVTFAQRVGDNILQSSIPGHALEETVSVSTCLHSEGYSPVTMGCCSIKYMDNMACRLSRSLVSQIGSFTCNSHQTLLDQFGLKMKELHALDGNLVLALAHLELPHGWNILGNSSGEVTEHKESLLHITVRWGLVKFSQFLLCLPGGRQALTLTNEEGDMPLDVAVKLGHSRLAEVINNFQGSHSTDFSRVQINEHALLRFVHSSGTLTLTLNHTAEHLLEADIKLFRKYFLDRALLHKTLDRKEERTEKRLPIPSSATRTEGEPENLVSGKSPPEREDVKHFPDSMVQPTENEDLHFERHHSFDVLKKSKNSSTFLAASRLSNMLNGSDEVYANCMVIDQVGDLDINYINVEGITAQSSPESMNSTLLSQNCACALPKETRQDIIALSENSQETVNSGECQPFMSPTSSHLPFKLRELEKEQSQLKKRSSSLDALDVDSEGEGNSEQSHICYPPETHISSATGITSGDELDSFETNVELDFNISRTESLSISSNLQSKDSLLSGLRSRSYSCSSPKISLGKTRLIRDYTVCDSSEEQRAYSLSEPSREKRIQEEEWDKYIIPAKSESEKYKVSRTFSFLMNRMTSPRNKSKTKNKDAKDKEKLNRHQFVPGMFSGVLPCFVCDKLILGKESFQCAICNASVHKSCRECALPCTKKLQEKYHNKNRPQAILGNSSFRDIPHPNSSSLHPSSMPIGLPTGRKETTCPGNSLSRSVPGTSLESFRRSVTSLESDADSSNWRTRSHSDELLQSMGSSPSMDSFIMEEVVDSSLWSDLSSDAQEFEAESWSLVVEPSFCSRQEKDVIKRQDVIFELMQTEMHHIQTLLIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEVHRHFFYSMKERRQESCEDSDRNFVINRIGDILVQQFSEENATTMKKIYGEFCSHHKEAVSLFKELQQNKKFQNFIKVRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYSKEGTEEHKDLCKALCLIKDMIAAVDLTVNEYEKKQKWLEILNKIENKTCTKLKNGHVFRKQALISKERTLLYDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEEGGRTSESDEDKKKTEARVARIQQCQEILSNQDQQICTYLEEKLHIYAELGEMSGLEDVHLEPHLLIKPDPGEAPQAASLLAAALKEAESLQVAVMATQTGDANHSSEENCGELGSTDALQASEVPEPSTASQVTEGEGRRESCNMESCIRGIVNNMAGPDAGEKAEYIDFPGSSQAEIIQAIQNLTRLLYSLQAALTIQDSHIELHKLILQQHEKMPHGLSFRGGLLQEQDKSRHLEKQREELANIHKLQHQFQQEQQRWYRKCDQRQREQEAKEKWLQEREKECQSQEELLSRSRGELDHQLQEYQQNLERLREGQRMVEREREKVRIQQSLLCHWKHSRQSSLPAAFSPGNEVTDLIRSDSLCHENSFFVNEALVQMSLNTLNKSNSSGVPQDILYPLNISDSDLTRTSENQTDLKMDISYHSDVTHELWRTTDPGHQVPSLLRGSKDCCNNDLEENQSPCSKTPNLNPGSTQPWQNPEAKLNLPSTSLHDGDSGDGVEENIVYL
The following text describes a protein:
Function:
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MRCQEMNGVDIDLRITQPDWTPTMYSLFEDDSSSSAGSPNTPTFSLKASESEDNDPDTEEKLCSVCGDKANGYHFHVLTCEGCKGFFRRSVSKGLHFTCPFTRSCPITKAKRRRCQACRLHKCFSVGMRKDMIMSEQALAERRALRSRKKQERQSRREPGPALGALTEEQLQLVSLLSEAQLKHFDPTLSNFKHYRPQPLVHVFVYNNHTIPSPAPFPTSGLFPDLNLSDPKYKNLSANPQLISSGSFLPDVLNDLPHFADLSTYMIQQVIQFAKEIPAFRALPMEDQISLLKGSSMEVAHVQFNRVYNIETNVFECGKHKFSIRHGVITGFQEMYLEPMMKFQIMLRKLNLHEEEYALIEALCLFAPDRPGVVEHDIIDEMQENLALTLKCYMDLHHPPPEGRFLYPKLLSLLTELRTLNEEYTRQILHIQDISSENVTPLMKEILF
The following text describes a protein:
Function:
May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.
Subcellular Localization:
Nucleus.
Sequence:
MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSKYVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSNIPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLSDAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAFVPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLLSIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTPI
The following text describes a protein:
Function:
Acts as an accessory factor in the activation of sulfur amino acids metabolism genes. Possesses no intrinsic transcription activation abilities. Binds to the MET16 promoter as a complex with MET4 and CBF1. Enhances the DNA-binding activity of CBF1.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSAKQGWEKKSTNIDIASRKGMNVNNLSEHLQNLISSDSELGSRLLSLLLVSSGNAEELISMINNGQDVSQFKKLREPRKGKVAATTAVVVKEEEAPVSTSNELDKIKQERRRKNTEASQRFRIRKKQKNFENMNKLQNLNTQINKLRDRIEQLNKENEFWKAKLNDINEIKSLKLLNDIKRRNMGR
The following text describes a protein:
Function:
Component of the phosphoenolpyruvate-dependent nitrogen-metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. Enzyme I-Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr). Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins. Enzyme I-Ntr is specific for NPr.
Miscellaneous:
MISCELLANEOUS: The reaction takes place in three steps, mediated by a phosphocarrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C-terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain.
Subcellular Localization:
Cytoplasm.
Domain:
The EI N-terminal domain contains the HPr binding site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate binding site; The GAF domain is an important site of signal perception in prokaryotes and eukaryotes.
Sequence:
MLTRLREIVEKVASAPRLNEALNILVTDICLAMDTEVCSVYLADHDRRCYYLMATRGLKKPRGRTVALAFDEGIVGLVGRLAEPINLADAQKHPSFKYIPSVKEERFRAFLGVPIIQRRQLLGVLVVQQRELRQYDESEESFLVTLATQMAAILSQSQVTALFGQYRQTRIRALPAAPGVAIATGWQDATMPLMEQVYEASTLDTSLERERLTGALEEAANEFRRYSKRFAAGAQKETAAIFDLYSHLLSDARLRRELFAEVDKGAVAEWAVKKIIEKFAEQFAALTDNYLKERAGDLRTLGQRLLFHLDDSVQGPNAWPERFILVADELSATTLAELPQDRLAGVVVRDGAANSHAAIMVRALGIPTVMGADIQPSVLHRRTLVVDGYRGELLVDPEPVLIQEYQRLISEEIELSRLAEDDVNLPAQLKSGERVKVMLNAGLSPEHEEKLGSRIDGIGLYRTEIPFMLQSGFPSEEEQVAQYQGMLQMFNDKPVTLRTLDVGADKQLPYMPISEENPCLGWRGIRITLDQPEIFLIQVRAMLRANAATGNLSILLPMVTSIDEVDEARRLIERAGREVEEMIGYAIPKPRIGIMLEVPSMVFMLPHLANRIDFISVGTNDLTQYILAVDRNNTRVASIYDSLHPAMLRALSMIAQEAEKHGLDLRLCGEMAGDPMCVAILIGLGYRHLSMNGRSVARVKYLLRHIDFEDAQTLARRSLEAQMATEVRHQVAAFMERRGMGGLIRGGL
The following text describes a protein:
Function:
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes.
Sequence:
MDIAKWVEHARTCYSTQLDTKIKVIGVIGKDYPDHGKGDNINCYLRENVFPVAATEDETCTIRGHFSEDDQILFLVMNGVDDVANIRKCLKSNPKSNYFDAMAESECQQIRMLHFLFISCHFIIIFEQTSRIDLELMRFLKKVNSARIQLRKKINQRLVASDLRDVSFNNRILSSAESEGRMVVPRLLIAFQRNNIRPDVNPGKKLQRELYEKLEKNLDNQFSDILKLYDLIDCGASSLCQLNETIPVVHLLNPKIVKRDIIGEMFEILMADAENTKISGNAGTLPSNNSFVKFLEDNFRSEKNEISLENVIELMNCLQCVLDGDLEEKHEKTAIQTFIKRIQNDHMEEARRLYTNAQRPGERRGADRFKDSEKPVKIRSKEEHLMRFNEATHYIDSVVGVNSREALSQLQAQCNEMWQSDMRACESVSMMGRSCVRKIHPTFGDQTAPEHRWTAHDASNTMISTCVCGRKQLIRPEPFSVKEANSDFYDHPDFKCCRRLWRYQFQLYQEDSEEKDDIMWADRESNSLRAAKKMAQREDELAEEDTDLDIPESLLDPDSTSPSDEDDVRVRTMSSSESSSQESDAYLRPTSRRDESMASKTERELTIDHVKRMQKLELAGKSEDFLITVPNSMTTGKLPIFPSWHLTSLGDSSIYSHGAGLKNQPNFKIGGDYLSPVVVLLDVNFDVWNRDLNKIRSEDFSRKCGKDNKDDSARVKLFVGFEYECSRGHRFFVDYNGEPLIYSKGSNVIRESAHRSSLGNVLQADLPIRRPCTCRKLPLQSAQLQKVHVVTPKAPVHITIDPKVLIPTHEGVYGTGQEPLELHHSKYYILHLPTVYSGPSGAWMPGEFNPEKQGVWMGGALKVAYKPVMSFKW
The following text describes a protein:
Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Sequence:
MSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDREFTPQAFGMPLSQVIANDRAYKLKQDSQRDEQKDASDFVAALLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRVRRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQNKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGVDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHAEDNVSKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSASSVLPAAGQACPQYPASVFTP
The following text describes a protein:
Function:
Transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. Plays a costimulatory role in T-cell activation upon binding to its ligand K12/SECTM1. In turn, mediates the production of cytokines such as IL-2. On resting NK-cells, CD7 activation results in a significant induction of gamma-interferon levels.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MTQQAVLALLLTLAGILPGPLDAQDVHQSPRLTIASEGDSVNITCSTRGHLEGILMKKIWPQAYNVIYFEDRQEPTVDRTFSGRINFSGSQKNLTITISSLQLADTGDYTCEAVRKVSARGLFTTVVVKEKSSQEAYRSQEPLQTSFSFPAAIAVGFFFTGLLLGVVCSMLRKIQIKKLCASGIKESPCVVYEDMSYSNRKTPCIPNQYQ