lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MVEMLNPFAFDNSKLLEVYQLKTLNPRSTWEKETTRNDSTENSEASRKQRSLSDIPDPLQPSRSMEGLLEQLNIPPEERHRYYINCNSFNTKLFLRNIHKDDTFKELADALESLNVSMTEEGNDLKNLVQTNFVRYVRCKSNLDQIYDQFNKRMSGNENFLGIDHLDESVNNMVRGTTMKVIPLVDQASKVKHYKSAIRYVQDNKELFDLPKTLIESVNKKDYGTLMSEYKNGCKLYAQTKQNHVVTKIWKEVETIIDQYRNHTWEQLLESVENENQEYFLPLISKLVDLKVEENPVNLWMTNRLKRFHTQLRTLSQTMMEKIVNAQHDILKNNIAENIDLTFYLNMETYSEDMKNVASRKYNLTDSPIVIEMWLLILKYITTISDLCTKFVEFWEHVERFMNNSYQTTLLNEKRKENIIGLGDQTQEEATMLQLSKTEIAVTREGGQNFVKLLNRALSDLFMSTQQSLGKEQAKVPEGAYPSHFGFIPPRCNSLSCLRYLPKIVDPILKFTTELAQLTITDDCIRILRTLDEMILDRCVGAISSTKLRDMSNSHELEDWEVFQVVGDEKYCITQYPEIVLCFNQYSIRTMRDILFSYEKLPVLNGISIVSYPSDQLVSVIELQQITSLESVLESILKNAAKDKDNPRNSHTILTLTNLQHIKAHTFPEILQYFDEAFESNLNAKKLEIFTLLKKMESSIFGNYLSGLKMTLRDILEEKFHDINWATHSSNSFRAGDYIIESLMILVTVHSECFQLGPQLIQRILKESQIFISKYLFEAFKPYIGHISSDGLLQITVDLQFFQRVLRGHLEHETVTILNACLQSCFQNDIPRMQRCITETDPIVTSNLNRTSVQFASFE
The following text describes a protein:
Function:
This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGPLAQMPTHTWCEAHPLVPAVAQQLEPEAPARGPCAQSRTTGCLASPPGRPLLRKSLGAQLTWGRSGKNFPAFGRRGGGPGGDEPPLMRNPRESSVGGPRPVQTLPPRAAWRGFVQTFPRCAGRNAGGGRLWCILDYSRTAPSPVKLQGGRRGQHRAGAAPGRRKGEDPHPESTLPMDTPACPGPRPLPPSRKRSPPAPTRPVLTLLLLVSVKQVTGSLLEETTRKWAQYKEKCLKDLLKEPSGTFCNGTFDRYVCWPHSSPGNVSVPCPSYLPWWSEENSGRAYRYCLARGTWQMLENSTDIWQDDSECSKDHSSEQNVEHHALLSTLQLLYTVGYSLSVISLLLALTLLLFLRKLHCTRNYIHMNLFASFILRALAVLVKDAIFYNSYSRRPNSDKEWISYVSEISASCRSAQVLLHYFVGANYSWLLVEGLYLHTLLEPTVLSERRLWPRYMLVGWAFPLLFVVPWSITRAQLENTGCWVTNRNKKIWWIIRGPMLLCVMVNFFIFLKIVKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFSKLIRLFMQLTLSSFHGLLVALQYCFANGEVKAELRKHWVRFLLARHSGCSAWVLQKDFQFLGKCPKKLSQAGRTRTREKLQPSLGGGNNHGQLLHLAMHGLGGLGPRPPRGHAAWPRGSSLSESSDGDFTLTHTMEEILEESEI
The following text describes a protein:
Function:
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MELKLFMLMICCIQIHGSKTIRQHACTKKHRNSFLWKLKREPPVYFFGTIHVPYTRVWDYIPTNTRKSFIESDNVYFELNLNDVTTGMALSRCAQLPVGMTVKEVLPPDIYFRLKRHLDYVKGAMTSWMTSVQRNKGLTASLMYNEIAGGWERKRPIWIMLMINALTKPDIRSRGLPVLDVHLARQAGVMGKHVGAIETAEEQCEPFNGLNRSQVIFALNQTLLIQEKVREGLLRIPYNMDDMVVQYNCGNTNSSLFGVGPTFVPLRSNHHPSTTESDDVIVQNDDVTNFDNSDSIDDAIFTDGAATGETNTSRDVTNDDIIMDNAMASEIDDYLKEELIFRRNKRMATRVQDLVRRRKDESLFFAFGAVHFLGEKSVLDLLSRDGFEIENVRSKPHDRRAVKSGSHQSRDEGHLKKTHHRKSGKSLRKINELWKQMKRRSEPVFNEDPFFRSPNRHFRFESGPETASEDIGDVIVVHRDGYYDDEIPRYVICYGINDATIASLNLIMVGILTLLSFFMTC
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSGHDIPIQLLDGGSIDVQHHDQMNAMDTAMNLDDVDVDLFGDSVMVDTALDGLSAPRPMPSKHLRQRLDDLRTHGCHQAIAWSRQGTIASITKDGRSVEFRFLRCRPEDAGWELSEPYLYGPAIIPMHTTAGPIVHLAWSTTTPTPELAVVDAVGRITILSLTIHLNRPFITRKWDADPVDDLHAVVGCYWLPLLNPRQLSVMYGPAVWVQPEDAKTPGDGLYKYESSYTKPTGPNHPNTNKSALVSITTNGLLRLMFQNNNTRLEETAIELESITSSDDLITHAALCNDKNALLIALATASKQLRIVKATISWGNDKPAEKQAHPQNAAITASISEQHVAVAPLLQHDSNDAVLDDSMSQLSHIEFLPSIPKDKNLQAHHNPVVLTVRSHLPAEGASLYEQEPTSVIDRWEVVSEQPQTLHPAFAQLNTGNGMTNPNSMTRLRKLDAVVIPKIVVSVQVMYLGKVVCFAFSDGTIQYRDRVTMMELFNEQNVHRVLSPHDVGFQYVNDTPCLQVAFSPTNCSYAQISEDWDIKWNSMRYTLTDASTALQSAQQSAVMAALTLALSSAVTTSINFDDILALARPYSDNPQFAASWVKDLVNLLKLNFDFSDEGHYDSLVRSPLFQISLSILNHMGFRGEFRPRPFEGKLSFLILQMRNFIVLVSLSLNAPKSLGISPLDEAEVVEVLVGCVTWAHTLIGWMVDCLFDLADNPAFISILKEQKRFPDLANFLRARGDVSLHLLCCSSARGFIMAACRRLAHLEGMSNRAIRYWEASRLKTENNDGSGGGGKVLPDSLYFAYRKMQRATSSSLIKVQELNEVLQGFAQDVRTAYQASLSRRQSGNNQPQQQHPSPQQNKNQPQQQQNAEDQFIKKAQAHCELDMLLGANPPPCFREVLLKFFTQTLPVFKSHVDPAKLYFANYEVLEIEENPRILAARKARRKYIDVFTKREIQFPTSSGDARGGGGGSGGGSAATATAAAAAAAAAAAGGEDDGKRGGITGTGEGQTPSQSTLAPGGGISIKIELGTGSTPNLKGVSTPAGGGGGGSSGNAKTAGGNNAAAVGVNAANGGVGGGGGGGGNTNNNGTAENTSNQWRRCVRCTAVMEDFPGNHYRAGFTFVMAQQRKCACGAWWALVPKTTGGEGATEGW
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MAMKRGVISVGPLESSIVKRRDNLKVRARAAAGVVASLRAQIKELQQQRDFLVTWKADMFTGADAEGSLVDVELQGVDGDRVHAHKAILASKSIEFEAMFRADTDRKVVWNLEMPYVALKAFVTFFYTGRVSSSVLIEYLTTLLDAAHKYNVQFLEVVCEDSLVKNMTSDNVISIFDVAKKHCSSGCKEAVLKKARSLGELSSFTEYKFFTQSNPGLLLELYELLTDRSDQSPTKKMKLSRAGSHMQLSGISPFGTPIYWHGTPMPGHPFRPVGFESACFPHLQGQRPPYEMSMLPRPPYGIPAFVPPMFPGGLPRGFLRGALTHSPGQLEAPILEEVVAGKKKVSEGEDPKKPKVTPWQQKEKRCLLRGVKTTHNKNKKFIATITVKGQQIGLGKCCSEEEAGRLYDRAAFVIGRKTNNELPDDMKEELKGISWDDFIASLQEVTALESGSFHHQIIFVPFYSNHANVKIHHGKLDNGDSNEIDCD
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Sequence:
MKKIANFAPRGAPLATFEMYGTSQNVRLPAAATATAISDSSIRATFMQMSKPNVQIKKDGFASLSEKIPMMDDHQEFLVAVTPSIALFDQTFIDYHPNVRILAVNFIQKICEKLGRDIVEFAPKIFPSLLLYSCDTEQEISNAAKAIFNGYFSTSEKKNAIISKLRSEISLRIKYSYNDLKDMEKHFSNNDEIENWGRVASATLILSTLLLSACKFAPEVLSSFGDVQLRRWISLKDAKFLPQSTTQMRSSAYLYIAINTQNDFFGNEYADLILKLIGSESSPLCQSRLIKLISIYMDKEYLTTEKVRSAILPALTLYYDPIKTGIPALLTRIADQSFVESALNTVSSLPDIELANLFFKILFDLSSDRIELKPSNDCLYQLFNGAISKTPPSRFLGQVDLKYFVGISSDPRVRSSLESGNDDRATEYLQYLDTQSCVDWLKTRETIGINTIIRLIKNLGSTIIRKTWPSIIDIPIEKASDQKRAELIQLYARTDEMPAIIKQFPETVRYFLPNWSAGYDCLRCDELLAMTGELLKQSIGLYRILIQIFPQNEKIESEMEEAILNEIQENEEADPVLFEYYTKPTEKVLTAFLNCLSVEVLEPGDKIIPLLVDHIPKIINDTKQNNLAEQVYKFIESSQIDPLSIDIHPKDNPVFYLELWEKIGFDKLPQDKFIELLSSTLNRKCPWLEIFLYIRNIDWTLVPSKLWDYCSLHPELSELAIKNNDVISLSAICASNNLSYDKLPKTGIVLEALSLIEPPMNINNDLISSVIQNEWNHFTPKSNLISNENLTISLRQVINVLEHSAPIIMSIDEFVPFIEKGAKSDNKFDFFLTLRILSILRDIEMRFDSLQETLQTVIDKSVEFYPLPSPVEREFASAMRIAQLLSPNKFLTLLKLVGHHFTSPTSKMLSKQFSQLIRYFNVWDIIECRLESNLNLTNPLSWHLIVLSLEIMPYQKRMDMVNSFTSELFSIFDSLSIESDDFINLISTFPATAFDWSTKLSNNILHPLNREMTKRGTQRVFEILAKKLKKVKLGNTTIQTNVRNMTISCVYVEDAASVPIKMDITLPDIYPFRREKVSCNIDKGENSSDLRSRVAAAIIQGQGVEAGIRSWHNYIVKELQEKEPCTICYSYLDDQQRIPKVKCSVCGQKFHGACLSKWFAHCLQPTCPFCASPWKPKG
The following text describes a protein:
Function:
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The C-terminal domain of FBXL5 contains a redox-sensitive [2Fe-2S] cluster that, upon oxidation, promotes binding to IRP2 to effect its oxygen-dependent degradation. Under iron deficiency conditions, the N-terminal hemerythrin-like (Hr) region, which contains a diiron metal center, cannot bind iron and undergoes conformational changes that destabilize the FBXL5 protein and cause its ubiquitination and degradation. When intracellular iron levels start rising, the Hr region is stabilized. Additional increases in iron levels facilitate the assembly and incorporation of a redox active [2Fe-2S] cluster in the C-terminal domain. Only when oxygen level is high enough to maintain the cluster in its oxidized state can FBXL5 recruit IRP2 as a substrate for polyubiquination and degradation. Promotes ubiquitination and subsequent degradation of the dynactin complex component DCTN1. Within the nucleus, promotes the ubiquitination of SNAI1; preventing its interaction with DNA and promoting its degradation. Negatively regulates DNA damage response by mediating the ubiquitin-proteasome degradation of the DNA repair protein NABP2.
Miscellaneous:
MISCELLANEOUS: Binds a diiron center, that can be bridged by a hydroxo group. The hydroxo bridge is not present when FBXL5 is in the reduced form and seems to play a critical role in regulating iron binding.
Subcellular Localization:
Cytoplasm, perinuclear region. Nucleus.
Domain:
The hemerythrin-like region acts as an oxygen and iron sensor by binding oxygen through a diiron metal-center. In absence of oxygen and iron, the protein is ubiquitinated and degraded.
Sequence:
MAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINGPHADTASGCQNLQCGFRACCRSGE
The following text describes a protein:
Function:
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Sws tethers Pka-C3 to the membrane.
Sequence:
MDVLELLRASVNGCYNTLFSDAWSQYVSKQIATTTYWYGALLAIGALFIAWFLYFKRLASLRLRDESARTLSALTAASGGDHRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVMRFARRILQLQRENRPLEMKTVEPPAEYLEETIDGSDRVPPDALYMLQSIRIFGHFEKPIFLKLCKHTQLLQLMAGDYLFKITDPDDSVYIVQSGMINVYICNADGSTLSLKTVRKGESVTSLLSFIDVLSGNSSYYKTVTAKAMEKSVVIRLPMQAFEEVFNENPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNHMRIKGSNPVPVTVPGPVLSQASQASRAMASRPATSPVTRMSREEHTLSDPDPNPNASAMLFAEVHGDAPYIDLYHHQQQQSSGVSVGGTHRSSGACTPTGSGGESPDGTGNATITNIDQRLVQSSAVDSLRRELGLSEEDTSIIEPFVEVRELEPNVTLITEGNAEDVCIWFVMTGTLAVYQSNADATRAAKQDSKNDMLIHFVHPGEIVGGLAMLTGEASAYTIRARSNSRIAYIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLESGRAVYRQDESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKGDLVGIVEMITETSRTTTVLAVRDSELAKLPEGLFNAIKLRYPIVVTRLISFLSHRFLGSMQTRGANASSAPVEANPVTHKYSTVALVPITDDVPITPFTYELYHSLCAIGPVLRLTSEVVRKQLGNNIFEAANEYRLTSWLAQQEDRNIITLYQCDSALSPWTQRCMRQADVVLIVGLGERSHMVGKFEREIDKLAMRTQKELVLLYPETTNARPANTLSWLNARPWVTKHHHVLCVKRIFTRKSQYRINDLYSRVLLSEPNMHSDFSRLARWLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPIDMVGGVSIGALMGALWCSERNITTVTQKAREWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHRIHTNGSLWRYVRSSMSLSGYMPPLCDPQDGHLLLDGGYVNNLPGHLWRYCRASMSIAGVFPPFCDYRDGHLLLDGCYTNNVPADVMHNLGAAHIIAIDVGSQDDTDLTNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPIDKYKTLAFGSFDEIRDVGYVFGKNYFDNMAKAGRLGRFNQWFNKEPPKRGNHASLNEYTFIDLAQIVCKLPETYALNAVDIFSEDEDFDGYISEPTTLNMDRHRIQVPRAGNSLSFSETELDSDVEIDLELERKVDKSTQSTPPTPNKKHPSTPTSSQGNLMHLPLSMKAKDKMQILDKLEREHKRRQKSKHKRDRSMQRDSKATLHPAPMAEATTQTPSSDVDIDAKLDQLRKLQQELEQGNESEQEQEQEQEQEQGHIQEPENVTEADTKN
The following text describes a protein:
Function:
Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes. May also play an important role in early urinary-tract development.
Subcellular Localization:
Nucleus.
Sequence:
MARFVPSPPPNCLSYKSEGRLGEQDWQAHFKVPCCGVDPSQLESEEAEVDVRERDTQRDREPKRARDLTLRDSCTDNSMQFGTRTTAAEPGFMGTWQNADTNLLFRMSQQVPLACAGRVLGADFCPNLEEPDQRLEVQAIRCTLVNCTCECFQPGKINLRTCDQCKHGWVAHALDKLSTQHLYHPTQVEIVQSNVVFDISSLMLYGTQAVPVRLKILLDRLFSVLKQEEVLHILHGLGWTLRDYVRGYILQDAAGKVLDRWAIMSREEEIITLQQFLRFGETKSIVELMAIQEKEGQAVAVPSSKTDSDIRTFIESNNRTRSPSLLAHLENSNPSSIHHFENIPNSLAFLLPFQYINPVSAPLLGLPPNGLLLEQPGLRLREPSISTQNEYNESSESEVSPTPYKSDQTPNRNALTSITNVEPKTEPACVSPIQNSAPVSDLSKTEHPKSSFRIHRMRRMGSASRKGRVFCNACGKTFYDKGTLKIHYNAVHLKIKHRCTIEGCNMVFSSLRSRNRHSANPNPRLHMPMLRNNRDKDLIRATSGAATPVIASTKSNLTLTSPGRPPMGFTTPPLDPVLQNPLPSQLVFSGLKTVQPVPPFYRSLLTPGEMVSPPTSLPTSPIIPTSGTIEQHPPPPSEPIVPAVMMGTHEPSADLAPKKKPRKSSMPVKIEKEIIDTADEFDDEDDDPNDGGTVVNDMSHDNHCHSQDEMSPGMSVKDFSKHNRTRCISRTEIRRADSMTSEDQEPERDYENESESSEPKLGEESMEGDEHLHSEVSEKVLMNSERPDENHSEPSHQDVIKVKEEFTDPTYDMFYMSQYGLYNGGGASMAALHESFTSSLNYGSPQKFSPEGDLCSSPDPKICYVCKKSFKSSYSVKLHYRNVHLKEMHVCTVAGCNAAFPSRRSRDRHSANINLHRKLLTKELDDMSLDSSQPSLSKDLRDEFLMKIYGAQHPLGLDGREDASSPAGTEDSHLNGYGRGMAEDYMVLDLSTTSSLQSSSSVHSSRESDAGSDEGILLDDIDGASDSGESTHKAEAPTLPGSLGAEVSGSLMFSSLSGSNGGIMCNICHKMYSNKGTLRVHYKTVHLREMHKCKVPGCNMMFSSVRSRNRHSQNPNLHKNIPFTSID
The following text describes a protein:
Function:
DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MFILTKIADLVQIAPQDLGKNASQAIEDNINLKYANKVIQKIGLSVEFRIVVFRPFKFEIMTGRISSSIESGIRVRTHFFDEIFVPAKMLPDGSHFDHNEQVFVWQTEDGTQLFFDNQETVRFRVDSEQWNDQAPLGPDKQDENEESRVVESPYKIVASMEEVGLGPCLWWD
The following text describes a protein:
Function:
Required for primary cilia assembly.
Subcellular Localization:
Cell projection, cilium. Cytoplasm.
Sequence:
MADSSERAAFREVLPKQGLLFTEQTPIPVLCKPKIMPMKSVTLEKLETMQREAQEAVKRQEEEQKLQGGMI
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MARTNVNDLLAFLAVARERSFTRAAAQLGVSQSALSHTVRALEERLGLRLLTRTTRSVAPTEAGERLLRNIGPRFAEIDAELSALTALRETPAGTVRITTGEHAAQTILWPTLARLLPRYPDIKVELVVDYGLTDIVAERYDAGVRLGEQVAKDMIAVRIGPEMRMAVVGSPAYFTARGKPKRPQDLTEHNCINLRLPTYGGLYAWEFEKRGHAMKVRVDGQLVFNTGLLRMNAALAGLGLAYIPEDLVKREIADGRLIRVLADWCAPFAGYHLYYPSRRQPTPAFAVLVEALRYRK
The following text describes a protein:
Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
Subcellular Localization:
Cytoplasm.
Sequence:
MQPQIILLKEGTDTSQGKPQLVSNINACQSIVDAVRTTLGPRGMDKLIVDSKGKATISNDGATIMKLLDIVHPAAKTLVDIAKSQDAEVGDGTTSVVLLAGEFLKQLKPFVEEGVHPRIIIKAVRKALNLCVAQINELAFKIEKHDTEKHRALLEKCAATALNSKLIHQQKEFFSKMVVDSVTTLDVLLPLNMIGIKKVTGGALEDSMLVEGVAFKKTFAYAGFEMQPKSYDNVKIALLNIELELKAERDNAEVRVDNVAEYQKVVDAEWQILYDKLAKIHQSGAQVVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTLKACGGAVMTTVQDISDKVLGTCAHFEERQIGSERFNLFQGCPNAKTCTIILRGGAEQFLEETERSLHDAIMIVRRTIRNDSVVAGGGAIEMELSKMLRNYSRTIAGKEQLLIGAMAKALEIIPRQLCDNAGFDATNILNKLRQKHAQGCQWYGVDIMKEHIADNFEAFVWEPSVIKINALTAACEATCMILSVDETIKSPKSGAGEAPQPPMGRGMGRPF
The following text describes a protein:
Function:
Involved in the degradation of salicylate via a pathway involving coenzyme A derivative. Catalyzes the aromatic hydroxylation of salicylyl-CoA to yield gentisyl-CoA.
Sequence:
MKVACIGAGPGGLFFATLLKRSRPDAEVVVFERNRPDDTFGFGVVFSDATLDAIDAADPVLSEALEKHGRHWDDIEVRVHGERERVGGMGMAAVVRKTLLSLLQERARAEGVQMRFQDEVRDPAELDDFDLVVVCDGANSRFRTLFADDFGPTAEVASAKFIWFGTTYMFDGLTFVHQDGPHGVFAAHAYPISDSLSTFIVETDADSWARAGLDAFDPATPLGMSDEKTKSYLEDLFRAQIDGHPLVGNNSRWANFATRRARSWRSGKWVLLGDAAHTAHFSVGSGTKMAMEDAVALAETLGEASRSVPEALDLYEERRRPKVERIQNSARPSLSWWEHFGRYVRSFDAPTQFAFHFLTRSIPRGKLAVRDAAYVDRVDGWWLRHHEAGPLKTPFRVGPYRLPTRRVTVGDDLLTGTDGTGIPMVPFSGQPFGAGVWIDAPDTEEGLPLALDQVRETAEAGVLLVGVRGGTALTRVLVAEEARLAHSLPAAIVGAYDDDTATTLVLSGRADLVGGTK
The following text describes a protein:
Function:
Functions in dendrite outgrowth and synapse maturation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Synapse. Note=Enriched at the excitatory synapses in mature neurons.
Domain:
The PDZ-binding motif mediates interactions with MAGI2 and SHANK1.
Sequence:
MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGSLTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNTSVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEARCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL
The following text describes a protein:
Function:
Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
Sequence:
MLSSNVAAKPKRRLKLKQAASSANQLDMIERRQLHITGIVQGVGFRPFVYRWATELQLTGTVLNNAKGVMIELQGPSARLDIFIQELATNPPPLARIDHISHGQLAIKLAETHFEIVQSDSQSDGTKDRSLAALVAVSADKSTCQDCLDDMHNPQDRHFGYAFTNCTNCGPRYSIINALPYDRHHTAMADFAMCPDCAKAYQDPLNRRYHAQPVSCPKCGPQLSLKTPKGELIALTPSLNSQDNSMAVLSAAANMLAQGHILAIKGLGGFHLMCDARNSHAVSQLRQRKQRKAKPLAVMMPSIEMAKQYVTGTEAEWQTLSSPERPIVLMQALDEHDLNPEIAPNIPKLGVFLPYTPLHHLLLSQFNGPLVATSANVSGEPIITDCDALISQLGHVVDAIVDHNRPILNGCDDSVVQLIQQPNGSTPQVQVLRLARGYAPLSFPLTAPLTRSILAVGAQQKNAIAFGFGANVFLSPHIGDLFSVSAEQYFERTLATFARLYHFSPELIVHDKHPDYAPSRWAEAQQQKSPDTQSGTSGSIQTLSVQHHHAHVLSVMAINQYQEPVLGFSFDGTGLGDDGSLWGGEVLLTRLDKAERLAHFEAISLLGGEQAIKQPVRLLLALLFEQMSLAAVQALDLPILKSLTPITLSNLHRIWQNGHTIKSSSVGRLFDALACALGLIDTTQFEGQAGMLIEAAARRADKQHLPSLILDLPLCSSEDDPRQVQVWCSSQLFKQLIVHITEAPLSSHRQSIIARAFLHSLGDAICSYAARYPSLPIALCGGVFQNQYLLEYCLSKLHLQGNIVLPNKHIPVNDGGIALGQLWYGIHQEANAELS
The following text describes a protein:
Function:
Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
Sequence:
MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYHITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNKTLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAERFSLFQIHLNQSPKYEEIFKFQLS
The following text describes a protein:
Function:
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
Subcellular Localization:
Membrane.
Sequence:
MAQQSVTPEKKSRFDGLKWLLIVALLVAAIVAEFYYSQVAWAIRAAVGIVVVVILLAIASQTDKGRRAWGFIKNARTELRKVVWPTRQETLQTTLVVIVMVVITALILWGLDSFFMWAIGWMAGQRG
The following text describes a protein:
Function:
Putative transcription factor. Probably involved in the regulation of floral induction.
Subcellular Localization:
Nucleus.
Domain:
The homeodomain differs form the typical one by having namely 4 instead of 3 extra amino acids inserted in the loop between helix 1 and helix 2.
Sequence:
MEIASQEDHDMPIPLNTTFGGGGSHGHMIHHHDHHAANSAPPTHNNNNTTQPPPMPLHGNGHGNNYDHHHHQDPHHVGYNAIIKKPMIKYKECLKNHAAAMGGNATDGCGEFMPSGEDGSIEALTCSACNCHRNFHRKEVEGELAATAMSPYHQHPPHRKLMLNHQKIRSAMPHQMIMPIGVSNYRYMHNNSESEDFMEEDGVTTASRSLPNLPYNQKKRFRTKFTPEQKEKMLSFAEKVGWKIQRQEDCVVQRFCEEIGVKRRVLKVWMHNNKIHFSKKNNINLEDNDNEKINNLNNVDLSGNNDMTKIVP
The following text describes a protein:
Function:
Acts as a transcriptional activator (By similarity). Activates transcription of CGA/alpha-GSU, via binding to the downstream activin regulatory element (DARE) in the gene promoter (By similarity). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
STATDSSYYTNQQHPAGGGGGGASPYAHMGSYQYHASGLNNVSYSAKSSYDLGYTAAYTSYAPYGTSSSPVNNEPDKEDLEPE
The following text describes a protein:
Function:
Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Probably by regulating HR, plays a key role during gametogenesis. Stabilizes MCM9 protein.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSANFRGRGFGRGGYHSWRRGRGGWGSAKGRGKEQKGDGKKTVDKHVSLQNPEPWLQQSTLDQFIPYKGWKLYFSEVYSDSSPFVQKIQAFENFFTKHIELYDKDEIERKGSILVDYKELTQDDNLTNLIPNIATELRDMPEKTLACMGLAIHQILTKDLERHAAELQAQEGLSNKGETIVNVPHITARVYNYDSLTQLKNVRATCYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFSFPDGKYSLPTKCPVPVCHGKSFTALRSSPLTVTVDWQSIKIQELMSDDQREAGRIPRTIECELVQDLVDSCVPGDIVTVTGIVKVSNSEEGSRNKNDKCMFLLYVEANSISNTKGQKPKISEDGTNYGTSMEFSLKDLYAIQEIQSEENLFKLIINSLCPVIFGHELVKAGLALALFGGCQKYVDDKNRIPVRGDPHVLVVGDPGLGKSQMLQAVCNVAPRGVYVCGNTTTSSGLTVTLSKDSASGDFALEAGALVLGDQGICGIDEFDKMRNQHQALLEAMEQQSISLAKAGIVCSLPARTSIIAAANPVGGHYNKAKTVSENLKIGSALLSRFDLVFILLDTPNEDHDHLLSEHVMAIRAGKKKTVSSVTVSRLSTQDSNTSLLEVVSDKPLSERLKVSPGENLDPIPHHLLRKYVGYSRQYVHPKLSPEAAQILQDFYLELRKQTQGLNGTPITTRQLESLIRLTEARTRLELREKATKEDAEDIVEIMKYSMLGTYSDQFGNLDFERSQHGSGMSKRSAAKRFISALNTIAERTYNNLFQYQQLRQISKELNIQVADFENFISSLNDQGYLLKKGPKVYQLQTM
The following text describes a protein:
Function:
Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.
Subcellular Localization:
Apical cell membrane. Cytoplasm, perinuclear region. Golgi apparatus membrane; Multi-pass membrane protein. Membrane raft. Membrane; Multi-pass membrane protein. Nucleus.
Sequence:
MLVLLAFIIVFHITSAALLFVATIDNAWWVGEEFFADIWKVCVNNTNCTELNDSVQDFSTVQAVQATMILSTILCCIAFLIFLLQLFRLKQGERFVLTSIIQLMACLCVMIAASIYTDRRKDIHEKNEELYAQTSGGSFGYSFILAWVAFAFTFISGLMYLILRKRK
The following text describes a protein:
Function:
Binds to 23S rRNA.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MKKIEDNNTLVFIVDLKVDKNIKAAVKKMYDIQAKKVNTLIRPDGKKKAYVKLLMHGRRL
The following text describes a protein:
Function:
Binds phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2) at the cell membrane. Negatively regulates the activity of phosphatidylinositol 4-phosphate 5-kinase MSS4.
Miscellaneous:
MISCELLANEOUS: Present with 1560 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm.
Domain:
The PH domain interacts with membranes containing phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2).
Sequence:
MIAGATAPSSQHEILIASNLIKKPSTSQNKTPTAQSSSGNNGAADGAPQGYHHHHHHHRHLWWPRTTDHQYWCVLRKNQFAYYKTRDEREAISVIPRFDILNFKISELDGILTVYTPSKDLIFKFPRGQNEKVGMELMHNWKIALEKFLSSPSGNESVTTGSDYDEEEDDDDLIVVDEKAGPSSSKHSCSLTMDEQLSREDKEFYRMFDPRNAEHQVCSGILYTKVKKKKLFNRAKWQKFNVELTNTSFNLYSFKTGKLKKSIKLDKIIDCIELDNNSKMKNDDTNFALITFDERLSFKAANDQDMVDWIINFKSGILIRKKLKAENI