lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Conversion of folates to polyglutamate derivatives.
Subcellular Localization:
Mitochondrion.
Sequence:
MDDISGRQTLPRINRLLEHVGNPQDSLSILHIAGTNGKETVSKFLTSILQHPGQQRQRVLIGRYTTSSLLNAKEEDISINNEAISLIEYSRIEKELIEADSSLKLQCNNLELLTSVALVYFAKKNCQWCIIETGLAGKQDPGSIIAGQSRVCCAITNVGISDEAFLCKFLSQITESSTNKAIFLLDGSNDEFVRNTITKRCHDVGCPLEITDPSLRDYNVHTDTWGTLEVRLPYSEEEYQIFNLRVAIAVLDFLSKEKKVCISKDQLSQGLISVDWPRSLHRLDYCYESTSGKKIALLLDNANNAKAARNLACHLRTTYGDTPLTFVIAITTGKKVSPLLDPLIRPQDYVIVTRFGSVVGMPWIQSLEPVNLLAFIKNRYTRNVNMQPDLQSVWTFLETSGLKTIVPVIVCGSLYICKELLRLHNCHLPV
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSSTAGSALLKPFVHWGQNKQFVFVRVEIAEIEDSPTIEILEEKLNFKAYGLGVTGMNFYGFSLDLYHNINILKSKYKITARGVEIELKKVGGDDENGACEKWPRLTHTPKKLFWLKTDFDRFAFDSSDESSENEANSGNGFNEFGDGYYKNANKEMVDRFHRQFKEADSETSSFDTRKHLKTIYLMLYNLFQWIGYVYIFSMLLVKLYLEGPESRKAAFKTFGPQMMVCQSIAVLEIFHSLLRWVKSSLVTTSLQVLGRGFVLFVVILPESKLHERDVVWCLFLTWSAVEIVRYPYYMLTILKREVGLITWLRYTVWIPLYPLGFIFEGTVMLISLPLFEESKKFTYPLPNPLNISFYFTIFLQLYMLLMLPGSYFLMQRMYEQRKKKLNENSDNKKTSIGKKTK
The following text describes a protein:
Function:
Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1). Required to stabilize NDUFAF5.
Subcellular Localization:
Mitochondrion.
Sequence:
MSVNGAVWGRVRSRFRAFPEHLAACGAEASAYGKCVQASTAPGGRLSKDLCVREFEALRSCFAAAAKKTMMGGS
The following text describes a protein:
Function:
Regulatory subunit of the dimeric uba3-ula1 E1 enzyme. E1 activates NEDD8/ubl1 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of ubc12 (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGTSAKMQKYDRQVRLWKAEGQNAIEKSHVCLLYANTVGCEALKNLILPGIGSFAVVDDTSVDFSMDGMNFFIQYDQEGKSRARCTASLLQQLNPNVEMEYLEMSPEALIDKNIEYFSKFSVVLSSNLKEKPLFRLEEYLRSHKIPLLHFNSVGFAGILRISTHEYTTTQSQPELPQDLRLKNPWPELINYVKSMDLDNMDSSSLSEIPYIVLIIHVLLKVSPAHAQNSQEADDCAMFRKIMEEYKGKCDSENIEEASSNSWKAFKEYKLPSNVYEVLHDTRCVKIQEDSESFWIMAHCLKMFYDETEFLPLSGLLPDMNCSTQQYVKLQVIYKEKSENDILKFKKYVQQTLKRLNRSVEEITDLEIKHFSRNCLNIKVMDFKTMKEEYQPTSNSVLESSSIDSNSLLPWYLAFRIYDTILEKHGKNYKEAFSDTTKTISVAQSFLSQIGLEKFFDVVYTAIQELERADGHELHSISSFIGGIVAQETIKLLAQQYLPLNNTFVFDGVHSRTETFKL
The following text describes a protein:
Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSTTEGFDQALTVFNPEGKLFQVEYAFRAVKTSGLSHVAIRCLDGVVLVSQLQSADRLVDTANNTFIHEINETSACMICGRIADGRRVIDRVRSEAVDFFRKWNYQPTADILCTRLADINQIYTQEAWQRPFGNIAVFAGWDPEQDRSLLFKTDPAGTNTGYFAIAVGVKEVELADALTVQVKSFPNGICESTQKGLDCALKIFQNVISTGLTGDDVEVAIYTKTGLKRLTPIEVDRRLGELAVQTE
The following text describes a protein:
Function:
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
Subcellular Localization:
Lysosome.
Sequence:
MAPWLQLLLLLGLLPAAAPASSKPPAAGAQAWELASPELREPARFALEMYNRGRAAGTRAALGAVRGRVRRAGRGSLYSLKATLVEPPCNDPTVCQLPVSKKTLLCSFEVLDELGKHMLLRRDCGPVDTKTTDDRNETFSSFLPLLNKDPLPQDFSVKMASIFKDFVTTYNRTYDSQEEASWRMSVFANNMVRAQKIQALDRGTARYGVTKFSDLTEEEFRTIYLNPLLKDAPGRNMRPAQPVTDVPPPQWDWRNKGAVTNVKDQGMCGSCWAFSVTGNVEGQWFLKRGTLLSLSEQELLDCDKTDKACLGGLPSNAYSAIRTLGGLETEDDYSYRGRLQTCSFSAEKAKVYINDSVELSKNEQKLAAWLAKNGPVSIAINAFGMQFYRHGISHPLRPLCSPWLIDHAVLLVGYGNRSAIPFWAIKNSWGTDWGEEGYYYLHRGSGACGVNIMASSAVIN
The following text describes a protein:
Function:
Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
Sequence:
MNATSSLVQNNSPLRFGSTEFRDRHFPQLVTLNTTGKDSSESQAPLYLDNAGAPPVPVEVVHAHAHSLAQTLLANPHSSMAAAAAYTSVSINRVRQRILRHFGVSTATHSVVFTANSTAAIKLVADRFPWSPKSLFCYHQSSHTSIIGIRSRFSDTKSVFCFQSKELDSILSLTESTNGNVSSINADETHHLLSYPAQSNFSGERFPLEWVQAVRSLDHIPQPFSSHSSSCHKSNWRVLIDCASMVSTTRLDLAKTQADFAVVSFYKMFGFPTSLGALIVRNDATSLLTTSPRKYFGGGTVAAIAANSEYHRFRSGVAEQLEEGTLPFTEILALNHGFEFVEKTIGGWDILSQHVTDLAEYAQSRLGELRHETDHQLPVCKLYSPMTQNTKGPIIAFNIQTSTGTLIHHSQFMTLASIHNINIRSGCFCNPGACQQYLEISAQDIKQNHEVYGHVCGGSTDIGRPTGALRISFGFANIVSDVDRFLDFIQEFFVSKHDAIDNGIVSGLTRPRLIPYISAIHVYPIKSCGAISVTSWPMCDSGLVCDRKWMLVDRIHFQPLTQKKCPKMCRILIEKLDPYVGMMQVVYSSEYETHKTNDDQLVIMFDPIMPHSDRVPLNHDPADYDHQLSEKGDFSIVPKKISQADEWFSRHLGVDVCFVRSSTTAHIQSATMANLDKHHHTTMTPSFANKSPYLIISQSSYDLVATRVKQKNPVAHVDIMAFRPNLVIHGLIPFSEDQWISKSIQLGGTQFEIQEHCSRCQMICIDQATCKRHSEPLSTLAKMHRIDGRVVFGVHAWSKDQHLEFKIIHVGDVYTPPKMNL
The following text describes a protein:
Function:
Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (By similarity). Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (By similarity). Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism (By similarity). May be implicated in airway host defense against infection (By similarity). May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation.
Miscellaneous:
MISCELLANEOUS: Thiocyanate (SCN(-)) and hypothiocyanite (OSCN(-)) are bound in the distal heme cavity. The iodide ion (I(-)) occupies a position which is stabilized by the interactions with heme moiety, His-224, Arg-370 and Glu-373. Hydrogen peroxide is held between the heme iron and His-224.
Subcellular Localization:
Secreted. Cytoplasm. Note=Expressed in the cytoplasm in intestinal epithelial cells.
Sequence:
MKVLLHLPALLASLTLLQTAASASDDPTAETDIIHDTVEEVKVWVNKAFLDSRDRLKMAMTTKIHSTRHLSDYLKHAKGRTRTAIRSGQVWEESLKKLSQFLTNVTGQGLDLTLLSWEAGCDPPAPTMTCNISSPYRTITGYCNNRKNPALGSANRALARWLPAEYEDGLSLPYGWTPGKMRNGFPLPQPREVSNQIAAYLNEEDVLDQKRSMLFMQWGQIVDHDMDFAPETEMGSDTYTKAQCDEHCIQGDNCFPIMFPPGDPKLKTQGKCMPFFRAGFVCPTPPYKSLAREQINALTSFLDASLVYSPEPSLANRLRNLSSPLGLMAVNEEVSDNGRPFPPFVKMKPSPCEVINATAGVPCFLAGDSRASEQILLATSHTLFIREHNRLATELSRLNPHWDRETLYQEARKIMGAFIQITTFRDYLPILLGDEMQKWIPPYQGYNESVDPRISNVFTFALRFGHLEIPSTVYRLDENYQPWGSESELPLHTVFFNTWRLVKDGGIDPLVRGLLAKNAKLMHQNKMMTGELRNKLFQPNHTIHGFDLASINIQRSRDHGQPGYNSWRAFCGLSQPKTLEELSAVMKNEVLAKKLMDLYGTPSNIDIWLGAVAEPLVHRGRVGPLLTCLLGQQFQRIRDGDRFWWENPGVFTEKQRESLQKMSFSRLVCDNTGIDKVPLNPFQANAYPHGFVDCSSIDKLDLSPWASVKE
The following text describes a protein:
Function:
Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The last loop motif confers selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA) to behenoyl-CoA (docosanoyl-CoA; C22:0-CoA) as acyl donors.
Sequence:
MWSSLNDWLWNERLWLPANISWAQLEDHDGLVFPHPQDTLMAVPLALALVVVRFTFERFVALPLSRWLGVRNQIRRPADPNATLEKHYLMKGREPTESQMNLLATQCGLTLRQTQCWFRRRRNQDRPCLTKKFCESSWKFVFYLCCFVCGTMVLYHESWLWTPVKCWENYPHQPLKPGLYHWYLLELSFYISLLMTLPFDTKRKDFKEQVIHHFVTIILISFSYSLNLLRIGSLVLLLHDSADYLLEASKLFNYMHWRRMCDTLFIIFSLVFFYTRLVLFPTRILYTTFFESIGNFSPFFGYYFLNILLVILQLLHVFWSWLILCMIYSFIKKGQMEKDVRSDVEELDSSDGEAAEECPQMKNGAAQRPGAAPTDGPRSRAAGRMVNRHTPAT
The following text describes a protein:
Function:
Transcriptional regulator.
Subcellular Localization:
Nucleus.
Sequence:
MALEESAIAVDSLANSINPSVTSLSTSIINLDRQLDHAVPSPSSDPPSSTKLNALAPAFVPRTSLAPPAATATAFHPVRNHFGYTPQLSVQYPSPFYGGVAQEIAADLDHATQKIVNQVEFYFSDLNLATTDHLIRHMLKDPEGYVPISVVASFKKIKALISSHAQLAQVLQSSTKLVVSEDGMKVKRKIPLTETDLEELQSRIVIAENLPEDHCHQNLMKIFSAVGSVKMIRTCLPQSSNGGASSGSRTAKSDSMLYSNKLHTFVEYESAELAERAVVELNDANWRNALKVRLLKSIAKSGQAQGKKAGHETEQNFKGDDGLEVNKTLNEESRHHIDAKSNELSEHGGDGQRRVHGRGHGRGRGRGKGQVHPRPQFQQNNRGGILGAPISNVNRGSSVGNAPSNINHVGLGQPDFEQSAAAKQSSVPRMPDGTKGFSMGRGKPMAIITM
The following text describes a protein:
Function:
Flagellar protein involved in sperm flagellum axoneme organization and function.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MPLMVLLLSQRTGGVAQLLSVHGLDTHRRNNLVLLDEDTAASCIAGQLVLLSLSTGARRYLPGRDGGGVGAVAVHPSRTLLAVGEKARPGPASAGPAVYIYSYPGLEVVKVLRGGTERAYSALAFDGERGDTLASVGHFPDFLLTLWDWRQEAIVLRAKAFSQDVYGVAFSPYFEGQLTTSGQGHIRFWRMASTFTGLKLQGAIGKFGNVELSDVAAFVELPDGKVLSSTETGELLLWDGGLIKVVLTRPGSRPCHDGPIEALLLDRPAGRVLSAGADGRVRMWDFGAVNDAEPREDSHSLELSPLDEVVVAEGAALSALLADSGGRRWVVADKAGNVYTVALPPAGPVGKGAVVTRVASHPAGAVAGLQLSARTHTALVASADGCLRALDYVSGAVLAEAATPQRITAFTPLPAASPACPGGAMTAATGYRDGVVRLHARCAEGLALVGVAKAHKGAVAALAVSADGGRLVSAGEDGSVFFFDLTAQPQPGTGVPGMPACGLLAPRAFIKLPSGSGTVTCGVWEAAEGGGVLLGTNRGTILSVPLPPPDLNTHHSYEWAAGTSAVSSYQLVVPKPKRPKKKKGKNDGEEGDKEGGEQDEGQGGEDKGGEQADGEGGSKEGGEEGRAAEEEEEEEADDEADGGAGGPSSTTGELISLTLAPNEPGALLVTAGGVGHAARKAWRVRMGEPLAAPLLEGFASAPVTCLAHAGPEGRLALLGSGDGLVRLQALEEPFGSAAPGALPLWEAPLHDMQSGRVSGLGLSHDGAYLVTAAADGALHLLALALPPELAPPPTTQPGDEPLPGPAALPLRPPDVLAAAAYTLEEEKQQAERDQQVREAEEKKLSVRQRLGLIRAEFEALLAENEAAPEALRLPRADLEVDPGLRALMEAEALRREEVARLELAWESERQRLGLAKLRRYFLDGLESERVVLHSLRGSSTVTTFRVAKLSDETRAELAAMRQAARAAAAASAAAGGEGGAGGRDTDARGKGSDTGGGPGGDAAARARLAEATAALEEGTASGKLNKADLRRLARKRREAEWAAFNGTRPDDTYDSPADLAAIEEARRTIGDFKLKSDPNYVVPEEERLTPQRKRLAMLELEEALHDIAAAFNAKFFALRDVKRKVLADVRVKLAALAELAAAAGAATGGADPDATAAAYLAPFSGLPSGLLPEEEPAEAREAVTDADLAAFAARKAEDERKAAAAAAGGLGGFAGAAAGPKKPAAGGAAPAGGALAGGAAGSGSVAHGAGGPSAGGQQGLTAAEEALAKMMAAVPQSELEKGLAAYNRRRVEHMRSKLSEEITAMLDAFDDAHSALKAEKLGLEADVKAGQMRLLVGLQELQLLREFDKRESVLLAKRQAKLDDKQEIVDKIAECTDKLETKRLELEGLVARRAAVVAELDAVVPESDPFREALVRVFHRRIKRSKKKAGGGGGEDDYDSEEDEEDEDMGDDEVDDDDDGGEEVCPPGCDQSVYERVCDLREKRLDEEDMIAEFTKTIEVLRKEKEALAKKQRLVEQGLAAVNADMAEFQKEKQGRLNQVEVIVALRMHQIEYLLDGCLPDDLSACLVFSASQLRRLQARVDELEEEKAGLRAAHKELRRQHAALLRDKADKEARVAELEARAHDVQMLKFGQVIDLELLDRVSSSRGTEELREDLKKQELAYARELAEWDAKINARMDELVVLTRENTACLNAVSELTAAQRRLESGLTATRKGLFADPVQQRRAEVEERDALVALVNAQAAELDRLKGQLLALRRKDTSMYA
The following text describes a protein:
Function:
Involved in autophagy. Plays a role in late steps of autophagy.
Subcellular Localization:
Cytoplasm, perinuclear region. Lysosome.
Sequence:
MATLEKPKKEKSKKSRNRVPIEKEEEEPAELSTSEEQRPAENVSLLEEFERVATLASSSSGEAIISHECCISSDVGVTSQEPEGTQEPTETEAQPSAPSAPPSTTVHVVQYPNLQPMQLSNAQVEEHSAKIVYRQAESPTGFALARSHIKLLSTEELRQIYDCPELELAKQFELEFLMNSLLETSEADPLYAAVMEYYELQGKITSNLHDVEKLRKGCAESQKQIWVRQPVTRTFSGTCGDGNVVQECVTYDVIQVDPIKLEVAKTSLTGLYDLVCHAYTNNSITAKITKVKVDQIINDLLTYPNLDGHSVVSLHHTQSGEALQCVSQLRRAISILFSFVRRPSPNANFDKDLKEWLRKLIALQLLLATREDHWFLLFNILRCPNGVGSWAAQFLQLPGTRAVRRGSQQNELPLDLNSPELNHCMAVLQILLMPVKKRNEYLKSQAQAHRELSDTPGATDRWIVVDSDGEDSHTPAGECVGLKESDLVALLNQMPFEKIFTSALRIEKFLDDYIIEPDMITAQQMLAVVVFFSQLVKTIGEGLLTYNNERYKQLAKRLGRLVRHTLQYVFDYNELFINNNLYKSSEMYERIQVELQALLVRACGYIYRTRNLGTWQYFSTLPFGTLDAEVIWHLFYYLNVGFPTDLANDLVSNAEAAFQAEDFWRKFDLANADVAPEDMYYLLQTFFEMANERNRSKDGSLVKAICLHIFHIGYIHKSTREICYKTARDMLANLMDEDLFGCVLVQLKMRYGEVDQAAYLFKALPLENWHPSMDTFEVLSNWLLHFDYQSSESQLARLIISHLNWGLDCEGRLFLPHNIHVRMAHLVNEALNKYAPEVIGASGISESVRQVSSLIDSTQSSREQFTNWCWRMVSVLRLHLMDQGVESVRRTLQHPTEPLLFIPELERMEMIFQGVNENRPLALYVGMLVSLHGHSIPLICQHGFILLQQLLLDHRHAATIRCLELIVPLFLETPETLANCESFQRLITTLLNADRTYLKLAKDMVYANSIGPILELLDNMLHHQIISYTSYGLCSPLNLLNIWLNCFTTLPGWSQNSNLLYLLDRMLRISYQFPDCRAQAVEFFYNYYKDCTEWKSAPKGSALKAFFGGQSVSRIPLISPQNCWLNLVILEIEFRLVDTRIFPELLRQISAQPVEAALKKTISLSKTSAFPASQLVIFKYAQLLASMESTHALFPIVCQKFFELYLWRVPTENESLNFSHNFGVSDKFYEYNVPLMKSIKSQLKSAESYYSALATKNANDDAMAHFYRNCCKLMQNCALWLEDTQINRFTSDAEHLPAQYNSEKLRELLSGHVNHWTEFLCLASLRKEQRHQADQWGRKVMRLSNQKAPRTPVQPKQRQPPAQHIKSLLKSYEKIVENPLHIRVEPIKTPPIDGVIVAQIQKKMTTLNSTANNYHYKTSELNSLDLNYLERVPTLYSMIPYEETRRKECTSLLFKRNCTAPAQIKLTPEHIRINDVISRKQAQNRERHDKIIEDILLAMSVESFAQAIEELGVCIGALLVAPLESSVTQIGVRVFYDIVDNLNEVTMKFQPTHDLYFQVLEKLGVFLEADQAAQGLAILRLALKRPDLLELLAGVFVPSRTDVDHFLSMYEFLIDSHLKHCDTQTLFVLFSKFDLLGWMEAYQPKLSEINRLLLLVLQGLEAWSQPDSSLLQDLFRRHLVHIFGYDFPQHYGEVMQLVLDRTSDQKLMPVVLLDLLNALFVRSNCAELSLQQSEVRVHELALDFARRQKLFTLKAATDTLLLLSRHFQKERLHHGLHGLYPKHKDYCQALVLWFTSFGHTLLASAICSYQELLADQISDIVFGSIVETYSPWLIPYTEETVSGVAHWIRQLTPGQSKVLLPWSEQHVSSCKLMIRSFVATIIQVLQYLPSSNKILEHVFAWYVHHFAQSSTTGHVLAPIHEGLAQLPWERFLPPAQHVELLYDSLQKFLPESHAMLGHIFIRIEWNNWFAQMPQPVSILSRLFTIFVKIAFEPNIHIHPNTSKILEDAIRYPWHLVECSELEQLLKWFVASVEPAIALKIPAESNYADRAVLELLRLACAMLPERSAQDAVVLGTAKRMLYTRSMVRMQRACGAKHQKLLATKEGERAFSNAFLELLDSIDGAISSCSEHRTMEEQRREALNLMLELVAPTQTQSQEVSNIHIKALVWWQQRCSPGNLVMCSTLPAIGHLNTYIASIYSLLEASIENYFRTSPEIASWHAPSWQGLMEALSMSLPKLDLMPIMQGSYFFSLHVFVLYKMEEIATDGDKVTFLQDLSQLLENLKTSPQTEPRMALVWGVIIARGCQIAQVNQQVKKPLHMLARHLQIASTKAEGWGDGLLGVIGLKSEVITNRRKVLTRCLACVIFSLFPANRDLRIPSEEYESALRELSMLLANKKFTDIKPLIVRAVSLLKESTFPDIRAVPHMVCRLISIFYEESYLTTIPEVWDFEFKLMAT
The following text describes a protein:
Function:
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization; Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
Subcellular Localization:
Cell membrane, sarcolemma. Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Postsynaptic cell membrane. Secreted, extracellular space.
Sequence:
MESHSGPHTCLTVLVMFTVLAVMLVSLGQAQEINGVYRDWYEPQSRDNLGDESDALEPSFGVWKPVSPGWGIPDTTATVGVAFSHKIPKEAFRGDVDKYMLKEVGAQSLPSWLNFSNKTNTLQGIPGKEDQRQYYISVTALGKVSNLTKDSSNTKDVFSINVLPQDTPHTKSTDESTSKHKDGVVVCPPEKPAVRATIILDADWSLLTPQERINMVSKLSKYSRIPMTAFKLLPEKDDNKGYQALAAGSGNIATAKHEGLSLSWVVGCGRNIDQLPVVTILEGASKDGSMAEKLNYDIKGWYVSSNTPIIKNRVRRQAPLMGTVVPTALPTGAPKPTEVLSTVYPSTHIIPTESSPVLSSMIRTAGTQDPMTMTAKETSTKTGKVSISPTVKASKTSFYKTSVITPTPTPVATTEVPTEAPTRAFSPPVPSMTATESLVVMPTMTSTPVASIPVDTMAPTTVVIMPTPTKPVTTPSDTIPEPTTPKPATPYVNKGPEIVHPIERIDVIVGVPFVFVVPADTYMDPEDGNTRELSLMLVDADGTLLSSDFWLKFDKQKQTMFAYTEKVFDVETYVMIAQDKEGVELRDAFEVHVLDSNAVQEDPPPVAMGATINIDFDEFINNPELQLDILNRIASIFGDPDASALTITGIRRGSVILSFTNNTIPKDTCPVELIEELMKKLVTPDGKPTQALIDAFSPNYTISGVEAAPQGTCDATTPAPTTPSTKAYVPPLDGNTKANDAWITNVLPGVIVAFIIILAGIVVFILYRRNRKGKLSDEDQNTFINKGIPIIFTEELDEADKHPSSTPLIMKNEKPPLPPPEYSAEDGTRQPLMSDHRSQDDPNKPSMPMVDLGGSPPYEPPPPITPSPPESRNPHAPSTTRFQSPPAYVPP
The following text describes a protein:
Function:
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides.
Subcellular Localization:
Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
Sequence:
MEHEQKSGAVLLRLLRLLWLLPHSWAVLEASTPVLWDDPQNHTFRHTLFCQDGIPNIGLSETYDEDELFSFDFSQNTRVPRLPDFAEWAQGQGDASAIAFGKSFCEMLMREVSPKLEGQIPVSRGLSVAEVFTLKPLEFGKPNTLVCFISNLFPPTLTVNWQLHSAPVEGASPTSISAVDGLTFQAFSYLNFTPEPFDLYSCTVTHEIDRYTAIAYWVPQNALPSDLLENALCGVAFALGVLGTIIGIVFFLCSQRPCSGD
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MENPAAKSSFWAKIIGLQLHDSYETETNGKTPSLSIVRILYSIILFGAYLVGLYKAVELTFVVEFAANSPSIFKFAYMTQIYSGVLATIICYASLWRTDRMKCIYIEGIQGSNVKINDRYYQFRNMQIPIKYSILVPFSIGMLIILSVCEAYAQYNHGYYFTIITIVYPLWMFHITILEFTTLVKSTECILTKLNWMLDTFLESLQRQSTPSVTLKGEKNPTNKVYPLNRRPFVQEHELISGERLTYMFVIHENVAKLAEFINGAYSTQIIAIVTVTFVNTLFGFFIVTKLLFWNYQMLDLILRACRYAFECIPACLLVYYMLIVCASTHSELFKSASLLHKLLQYKSNYFIDDQALFERSKAIALQLLHRKRFSLFDGSGLFRLDFTFIFSVFSAATSYLIVLLQFDLSKDLEKSTITA
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MNKTNYNNIISINQQREFVLFQNIQKECPLLVVFDLDDTLIHTHINTNNLCINSSDIFTIRVNEIKYYCEVRKGVVETLERLSKQFRIMIYTASKKEYADQVVSHLEKNCKLFSKILYREDCLEEEGFIYKTIHNINYNVKRIICIDDNPSAWKKLENVYVCKKYNGGIDDEMIDIENIRTFIKCCILCFLFV
The following text describes a protein:
Function:
Hydrolyzes 4-hydroxybenzoate-CoA, and to a lesser extent benzoyl-CoA and 4-chlorobenzoate-CoA. Not active against aliphatic acyl-CoA thioesters, including palmitoyl-CoA, hexanoyl-CoA and acetyl-CoA.
Sequence:
MARSITMQQRIEFGDCDPAGIVWFPNYHRWLDAASRNYFIKCGLPPWRQTVVERGIVGTPIVSCNASFVCTASYDDVLTIETCIKEWRRKSFVQRHSVSRTTPGGDVQLVMRADEIRVFAMNDGERLRAIEVPADYIELCS
The following text describes a protein:
Function:
Secreted L-amino-acid oxidase that acts as a key immunoregulator. Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively. Also has weak L-arginine oxidase activity. Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR. IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer. AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity. Also has an immunoregulatory function in some immune cells, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4(+) T-cells into FOXP3(+) regulatory T-cells (Treg) and regulates the development and function of B-cells (By similarity). Also regulates M2 macrophage polarization by inhibiting T-cell activation (By similarity). Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4(+) and H2O2 (By similarity).
Subcellular Localization:
Secreted. Lysosome. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Secreted at the immunological synapse.
Sequence:
AFKDLKALGCKKAMNKFNKHTLLEYLLEEGNLSRPAVQLLGDVMSE
The following text describes a protein:
Function:
Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEVTLLVRDKEVVIPGQPLARGKVKPGKDVYVDESGTIRSKKLGLVSLKDDEISIVPLVGAYIPKEDDLVIGIVSKISGNTILVDIRSPYQGALPIQRRAERVDLKKYDLKIGDVILAKVRSFDGASSLILTIDAEGLGKLEGGYLLEVDPAKVPRVIGKRQSMLSMLKEATRSEIIVANNGRIWVKPPSVKELIVLEKALKKIEEESHVSGLSDRISSLLSQELSR
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLPRLALSRGAAAAAAPLTVTISTASATCVSPRWCSSVTSDKPGAADSNPFTSAIAKTLREKVFSQDFAAVKAASPKETELLKKWRTVDGTPAKSPRQPATPGTADSSDVEPQIAEGARNVAMSHGTTFRDSRPVDPKESVECKRRRLIYQSRYRGMVEMDLIFGHFARCKLETLDASMLDEYDMLLKQLDSELFRWLVMGVDAPEGVAKLRCFGELRRFIKEERTALLGSN
The following text describes a protein:
Function:
Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
Subcellular Localization:
Mitochondrion.
Sequence:
MLAVTSCSMKTVLQYAVFLGHSREVVCELVTSFRSFCSHCAVPPSPKYGGRHTVAMIPGDGIGPELMVHVKKIFRSNCVPVDFEEVWVTSTSNEEEINNALMAIRRNRVALKGNIATNHNLPARYKSHNTKFRTILDLYASVVHFKTFPGVMTRHKDIDILVVRENTEGEYTNLEHESVKGVVESLKIVTKTKSVRIADYAFKLAQKMGRKKVTVVHKANIMKLGDGLFLQCCKDVAAHYPQITLESMIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSICTGLVGGSGIVPGANYGDSYAIFEMGSKEIGKDLAHRNIANPVAMLLTSCIMLDYLDLQPYATHIRSAVMASLQNKAVCTPDIGGQGNTASTVEYILHHMKEQTSGCHPNFFLQFT
The following text describes a protein:
Function:
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription.
Subcellular Localization:
Nucleus.
Sequence:
ESESESGQAEEEKEEAEEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASEPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPGLTPGLPYPHQTPQGLMPYGQPRPPILGYGVPTGGPPYPHAPYGAGRGNYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF
The following text describes a protein:
Function:
Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis.
Sequence:
MLRGAPGLGLTARKGAEGSAEDLGGPCPEPGGDSGVLGANGASCSRGEAEEPAGRRRARPVRSKARRMAANVRERKRILDYNEAFNALRRALRHDLGGKRLSKIATLRRAIHRIAALSLVLRASPAPRGPCGHLECHGPAARGDTGDTGASPPPPAGPSLARPDAARPSVPSAPRCASCPRQAPLARPSAVAEGPGLAQASGGSWRRCPGASSAGPPPWPRGYLRSAPGMGHPRS
The following text describes a protein:
Function:
Forms part of the polypeptide exit tunnel; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
Sequence:
MTKTAVYTTTGTKDGEVELPAVFSTPFRRELIHKAFTNLTSHKFQPQGRHPTAGQDVVADSNDPPTGQGVSRVARAQGGGGGRQGQGAEVASTRGGRQAHPPIVEKVIYKKLNKKEKKLALCSAIAATASKDRVESRGHKVEGIESFPIVVSDDIESVSKTSEVSKILDSLKLTQDVQRLETRKARSGQSRLRGRSKKVGKSVLFVTKDASNISKAIGALPGVEATSVKDLSVLDLAPGSDPIRLTVYSKSAIEEIGKIKSTHLEVMAKVQ