lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
MTVPNVWSLETPSDMKETFPAVFNDPTSSTGDAKITCNLFQSVSFNSHLFDSPVLGDGFSASHRYIPNEHHRVVAGVSLGSAGNLTSWSGGKPEPKTPQHVPPLSRNITINQHFGNQMPPEQYNECHNNQFLHESTTKGMSCMAQMPFCSTVNNFHNADVPFSMGHVQVKDGAGAPEAFTDPSIYGDTRLMFDWKFSSLNVSSVPVSPFVSSIDSKIMKGRFIGSNFELTDMISMQHPPPGSGSLLQSYLKAQVHDSQQGHLCQIKQKCMGSQPSLQGPHPPYDPFVQHQFLQKDQYQQQEENKVGNQDFASSHSESFLNGPRLMNSQNLLDVVPIEPLAIHDVIKHEQPPPMFEGIASDVDHLTTIPQRPTRFQAIHNVLFLYEHVRNCQDDGKGCILLQCMNLKRNLHHILHCKDANCTKNCFKYKRLFDHYTECCKSLCSICGPVRMRLKEVSQRNFSNAFTEPETTLPAVPRPDHKESAFKRAKTMHHFDQNGTHHVSLPVMNCSLLTDTGVSQLGQEVSIPVDMKTDSPEPVEKQSVDSNFRDSGEIYDTKIEDTEVKIQEGFGVEPAELAQVVTHSEQENLVQLEFLEADISSQCDITLAAAAKVSETKMDNPKRVVSLLDTFTAEMLREHIRSLEQHISKDKANTSESQGMEHLVDQNFCSLCGMEKLIFEAPPRYCSSCYKQINPKGVYYTMRSFKSTKYGCGAKISFCGKCHGASGESIKVGGEDIRKSDLERRLNYAETDAETEWWVQCDKCKAWQHQICALFNGKRKEALQAEYICPKCYLEELERGKCEPLPQSSILGASDLPKTILSDHIEQWIFQRLKQEREERARILKRSVDEVPGAEGLIIRVVSSVDKKLEVNPNFREVFKEEMYPSHFPYKSKVILLFQKIEGADVCLFGMYVQEYGLDCAFPNQRYVCISYIDSVKYFRPEIKAATGEALRTFVYHEILIGYLNYCKKCGFTSCYIWACPSLRQDYYILYCHPKTQKTPKSDKLREWYQTMIRKAMKEKVILEHTNLYDNFFVHTSECKTKVTAARLPYFDNDFWPGKADILLQEDKNESQRKGTKAVIERALRAAKRDASAGNPKDILLMHQLGEIIRPIKEDFIMIHLQHTCKYCYLPIVSGKQWVCNVCKNFHLCEWCYDKGQNLDMKDRHPVTSKEKHSFRLVESDGLADTDDKDKMMQSKLFDMRTGFLGFCQSEQYQFDTLRRAKHSTMMILDHLHDPTAITTASSCAICHCNMDNDQNWHCMICQDYHLCADCYHKKGASYHKHQLVSHATMADRTLQPKKQRNGKINIQMILDALLHAPKCCAPQCAYTCCLQVKKLFLHSRKCKVRAHGGCISCKKIWLLLRWHVRVCQEFDCHVPRCKDLKDFTRKMRHSRSKESSSKVVSESSISPDQQLPSIFASLEGPL
The following text describes a protein:
Function:
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein. Membrane, coated pit.
Sequence:
MDMRGLAHFIRDIRRATGNKKEEESRVDEELAKIRAKFLETSTMTTYDRKKYVCKLMFISMLGYPITFGHIEGLKLMSQESPSAKLIGYLSTSVLLNENSDLLTLTTHTVYRDLLSVSDLSRSLALTAVANTGSRDFVEVMHEGVFSIVMDDSVNQHIHKKALLTLLHIYRKYPEIVDLNTVIPKAAELLLSTQDGVSMCAVAFLSGCISKESRHLYRGIPDKLIQVLARIILEKQTEPGYVYYGVPAPWLQAKLLRLLQYFPLPSEADQRNRIILVLRKVVKATDKVLKDAQTQQKQRGTQSRVSAMNAVLFEVVSLCIQWDVGSKLILECVALISSFLSDKRESNLRYIGLSLLARLSFVDVPGFDFHMHCRQHQQQIIVGLHDSDASIRKKALDVLVAMCNRSTADDIIKELISYLPIAADPDFKTSLVLSIALLSEKYCKDYNVYVDIMLTVVSEAGDLCPPDIVQRVVQVVVNDPSVQKRAANIVFQELRKKTNVPEVMLRVAAFVLGEFGYQIALNAESTPMVQLNLLTQKLSFTSVVTQSIIISTFFKFYTLYDDVAVRERIMKTLQAYTKSPHPELQQRATEFIALVEFGRSELLEKVFEPMPPFRADVNTVMNQVKRLQSSVQDIWALKILERGVEDVNDTGKRKSKSESAEKPKHQAKRRITLHDLSPVSTAAPVQGGNADQAYAELDALLDVSLPSQDVDRVRSVYEEHRRRLFELSRADKGVLFSNESIELHCTKSTYGADTRMTVVVRDKTGKGLVQVAVEIIRADAGLILQSRTKDGTTVAAWGTITIEFAARSCFAFRSPPSVRVQYAPASDSARVRTDVLSLPTLPTTFFTPYQVDSDVNFSRLYEATKQASTFAGWRKEVSPSARVDANALMQLLELQGYRTKETGSGAIVGIAAFAVQPKERVEYVPVVCEIQTSASEMQVFVYTESSVLQHGALDTMEFALR
The following text describes a protein:
Function:
Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) gives rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. Required for normal endosperm development in seed, and thereby also required for normal embryo development.
Subcellular Localization:
Mitochondrion.
Sequence:
MVMTHFSRLRQLLLLQPKFLSSQPRPLRSPPPTFLRSVMGSSSSFSSSSSKLLFRQLFENESSTFTYLLADVSHPDKPALLIDPVDKTVDRDLKLIDELGLKLIYAMNTHVHADHVTGTGLLKTKLPGVKSVISKASGSKADLFLEPGDKVSIGDIYLEVRATPGHTAGCVTYVTGEGADQPQPRMAFTGDAVLIRGCGRTDFQEGSSDQLYESVHSQIFTLPKDTLIYPAHDYKGFEVSTVGEEMQHNPRLTKDKETFKTIMSNLNLSYPKMIDVAVPANMVCGLQDVPSQAN
The following text describes a protein:
Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MANTCLQFCGFVVSCLGWIGIIVATATNDWIFTCKYAVTTCKRMDELGSRGLWADCVISTALYHCIALTNIPSLPAYMQAARALMVGASILGLPAVALVLMAMPCINLGSEPDSAKHRRAVLGGVLLLCMGLCGVVSTVWFPIGVHYEVGLMSFGFSLYAGWVGSAFCLLGGLMISCSSGGSTRRTEERFYYSKQGASNPNPSSNHAKSAHV
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MKLSTSGLSQLDDEGEGGEEKKCLNSELWHACAGPLVSLPTPGTRVVYFPQGHSEQVAATTNKEVDGHIPNYPSLLPQLICQLHNVTMHADVETDEVYAQVTLQPLTMEEQKDTFLPLELGIPSKQPTNYFCKTLTASDTSTHGGFSVPRRAAEKVFPPLDFSQQPPAQELIARDLHDVEWKFRHIFRGQPKRHLLTTGWSVFVSAKRLVAGDSVLFIWNEKNQLLLGIRRATRPQTVTPSSVLSSDSMHIGLLAAAAHAASTNSCFTVFYNPRASPSEFVIPLSKYVKAVFHTRVSVGMRFRMLFETEESSVRRYMGTITGISELDPVRWPKSHWRSVKVGWDESTAGERQPRVSLWDIEPLTTFPMYPSMFPLRLKRPWHPGVSSLLDSRDGANGMMWLRGVTGEHHGLNSLNFQGVGLLPWMQQRLDPTLLGNDLNQQYQAMLAAGMQNLGSGDLLRQQIMQSQQQPFQHLQQREIHTSLLQQQQQQQHQQQEAINQVVPHNVLQVQTQGLTENIPPPLLGQPLNNQQEEQARQHQHTFQNALNFRSDQLHQRIQTNVPSSFAKTDFMDPSTKFSASVTPRQNMASFFCPEGSSNLLNFSRVGQSMLAEQLPQQSWASKYTHSHVTDFTHSTSRTPYPGKDATEEAENCISDSHNPAPFGVNLDSSGLLLPVTLPTFATSVDADVSLMPLTTAGFQNSLYGSVQDSSELFQSSGQDPPIPSRTFVKVYKSGSVGRSLDISRFSSYNELREELAQMFGIGGRLEEPLRSGWQLVFVDRENDELLLGDDPWEAFVNNVWYIKILSPEDIHTM
The following text describes a protein:
Function:
Proton-selective ion channel. Biphasically modulated by acid and alkali, mediating proton influx and efflux in response to extracellular acid and base stimulation, respectively (By similarity). May be involved in acid and base perception (By similarity). Sensor for ammonium chloride (NH(4)Cl) in taste receptor cells. NH(4)Cl acts by increasing the intracellular pH, thereby generating a driving force for proton entry through OTOP1 channel. Plays a role in the regulation of Ca(2+) flux in response to purigenic (ATP, ADP and UDP) stimuli, leading to increase in cytosolic Ca(2+) due to influx of extracellular calcium. May play this role by inhibiting P2Y purinoceptor-mediated Ca(2+) release in a Ca(2+)-dependent manner and promote an influx of Ca(2+) in response to ATP. Through this mechanism and possibly others, plays a role in the formation and function of calcium carbonate-based structures in the vestibular system of the inner ear, called otoconia, that sense gravity and linear acceleration.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, microvillus. Note=Found in the gelatinous membrane overlying the inner ear macular epithelium. Also detected in the apical microvilli in inner ear supporting cells.
Domain:
Residues involved in the gating by extracellular Zn (2+) and pH are located in the extracellular loops between transmembrane domain 5-6 and transmembrane domain 11-12.
Sequence:
MVEHGGTDSMWLNKYNPAAASSASSSSSSDAENKLFSRLKVSLTKKYPQKNAELLSAQYGTNLLLLGVSVMLALAAQSGPVKEEHLLSFITVLMLVQLVWMLCYMIRRERERSPVPERDAHAGASWIRGGLTMLALLSLIMDAFRIGYFVGYHSCISAALGVYPIVHALHTISQVHFLWFHIKDVIKKYETFERFGVIHAVFTNLLLWCNGVMSETEHFMHNHRRRLIEMGYANLSTVDVQPHCNCTTSVCSMFSTSLYYLYPFNIEYHIFVSAMLFVMWKNIGRTLDRHSNRKRRSTGSTGLLLGPLGGLVALASSVSVLVVYLIHLEKTEEMHEAAVSMFYYYGVAMMACMCVGSGTGLLVYRMENRPMDTGSNPARTLDTELLLASSLGSWLMSWCSVVASVAEAGQKSPSFSWTSLTYSLLLVLEKCIQNLFIVESLYRRHSEEEEDAAAPQVFSVAVPPYDGILNHGYEAHDKHREAEPAAGSHALSRKQPDAPLPAGQRLDVTPGRKRQILKNICMFLFMCNISLWILPAFGCRPQYDNPLENETFGTSVWTTVLNVAIPLNLFYRMHSVASLFEVFRKV
The following text describes a protein:
Function:
Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRFTLKKIFFVFLTLLIISIGYLLLQSVDLQRIRELLHDSEKFDLESLKQASLEIRKEIHYTNYLFSGYDNFTQQFSDEETLKQTSLNDKCKLVFTQWKESHPDFEFKTFEPEYERYDKSSDRKELFFKERINQLRKRFEKDSNNKNKQFTLSRQDNKTISQEYMEHVNRSKNVLQFMADFVSMMRLYGKCFFGRELDDELKSIYNEFRGKLFPFISSQAPKFRKSGETEEFGWPIYDNENNIIDRKTEFGDNPIEFLQKNSKGKGIVISVSTRYAKDAMRLIKILRALNNRLPIQIIYKNDITKKNIELLEFAAVATPEELFDPETIRDGAKFMPELNLLEHYKNYGSEFPIQDLTFVNIAGCVSRPYRFSFPGYSNKILAMLYSSFEEIILFDADVVPTVNPQEFFDSKYYKSSGTYFFQDRSLRDFNDFIETNFFSTLFPSNEKSIETIFDIPRVGEKTFNNKYMTGWRHYQEAGVVAYNKMQHFLGILMMFPLALWSEPVQSSIWGDKEMYWLGLSMAGDENYEFNKYAAASVGEKTTEQKYKYYPNSDSNEVCSTHPGHIDDNGRLLWINSGFSYCKKNGYFRDKGKFPFSTFELNDLVELYNSPIKIRAGLVPPDLPNQREPGSPPDTKPEMEFRKSWKSRKKDTDEINEKLPEGQEPYDFISEWGPQKGWVKNGICSGYYYCAYDKITSYSSEKEFDTGTLFEFDTKSCELYDYLSKIWHTGGSKMKPKVKLETEKLGTGSDKEQXKDATTVRLRI
The following text describes a protein:
Function:
Catalyzes the synthesis of activated sulfate.
Sequence:
MAALLSSAAHLLLLRTDAFSATTSTTTTSTTSSAPFSSSSSSSSHSLVVHAYQSAAAGGALLSTTRIGPGARRRRWRQLAVFSSAELLSSSSSSSSSERRRPSARGLVGEEEVEEEEEEVRPESCGSRGGGRRKSSGGSGSSSSRRSRRRRSCCCSSSSSRGAASARSSSSTSSSLQWQESLVTMDDRRRLLQQKGCIVWITGLSGSGKSTVAFAMDRILNSMAKVSYVLDGDKIREGLCKDLGFSAEDRRENIRRVGETAALFADAGLIAVVSFISPYKRDRDIVRELVPTGNFIEVFMDVPLEVCEERDAKGLYKLARQGVIKAFTGIDDPYEKPVNPEIVIKAVNEHGACYSPDEMARIIIHHLSEKGFLSE
The following text describes a protein:
Function:
May play a role in the regulation of DNA replication and cell cycle control.
Miscellaneous:
MISCELLANEOUS: Present with 1200 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSNPDDLDDGLAYDFDAEHEVIFDAKDGSPPTKKVQKRSIEQDDDDVDDIDGKKEERNSEDDSNRPISKRQKKLQKKSKLIEKKKEESQYIVSQRKALPASSPEKIIEYLTTLIREKNPDLSVLELEELYFKRNDFLSTEKFDAERRLSNFPAFIQKFSVAPKKIVFSMSNIRVADVYRSLNGGKNCVKLFSKSKLKDDIATVERLLTDSSKKSNKNKDSLYFIATPTRMQKIIEATDLLFQGKEKLDIILDASYLDPKDNTILSFENAAVLCQVLKTFLNKKSSVKILLY
The following text describes a protein:
Function:
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVAGRKAFALQAGDALSPDKPAEAQPAQVKTDLAANRQDAVFRYAQNGVQVTKTITLHPRNFKVDVRTEVRNGPAQVNMLFPGLGKADNPRVQAVPVGGQPASVQGSGTLSVQNIQYAALQENPSQIAHALIVRPQQGTKVDVQLTGGPQGLVTATLPATSSLEVYGGKNELIHLYQSGYTELPGLFQPNFFGQISLLIVKLMEALYKVIGNWGLVIMALTILLRLVMWPLMQAQGRTTARMQLVQPLQKEIQEKYKGKTDPESQRAMQMEMAQLMRDYQVNPAGCFSTLLPFPVLIALWATIRNFEFDSGFLWLPDLATPDPFYILAVIYLFVNLGQLYVSTRKTPEMFRQQAMIYLVFLYFALTFPSGVTLYIILSTIIGIVQQIIINKQVEHETASLGQTVQKVAPGTRPASKTTVTKTIDAPKK
The following text describes a protein:
Function:
Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MTSENHTTIKADSALVMSPTGSTSQAAPFSPSTSKPIQELPDELIQAGWSKCWSKRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNAAPASGEANADAGLGNGQRKRHPSEDASQAGPNSFKRPKVEIPATPTTPTVPISPSTPGVKPWVNTTTDEKQGQASTPAPAPYRPSVVYWDLDIQTNAVIRERAPADHLPPHPEIELQRAQLTTKLRQHYHELCSQREGIEPPRESFNRWLLERKVVDKGLDPLLPSECDPVISPSMFREIMNDIPIRLSRIKYKEEARKLLFKYAEAAKKMIDSRNATPESRKVVKWNVEDTMNWLRRDHSASKEDYMDRLEHLRKQCGPHVASVAKDSVEGICSKIYHISAEYVRRIRQAHLTLLKECNISVDGTESAEVQDRLVYCYPVRLSIPAPPQTRVELHFENDIACLRFKGEMVKVSRGHFNKLELLYRYSCIDDPRFEKFLSRVWCLIKRYQVMFGSGVNEGSGLQGSLPVPVFEALNKQFGVTFECFASPLNCYFKQFCSAFPDIDGFFGSRGPFLSFSPASGSFEANPPFCEELMDAMVTHFEDLLGRSSEPLSFIIFVPEWRDPPTPALTRMEASRFRRHQMTVPAFEHEYRSGSQHICKREEIYYKAIHGTAVIFLQNNAGFAKWEPTTERIQELLAAYKVSGRSLPSPGPSSTNTGEKDSKPAPERTAPSQDNSSPVDKTAQDTTNT
The following text describes a protein:
Function:
The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSTWAEQDIRLDPAIRNWVLLPITFVMLLVGILRHYAMQLLHSDPKPIGLKQLREQRALMRSGYFRNNCHFLSPSRFEERRNRLINAFLDGHYLSETGKPQSKSVITDPNNPKSAGNQDELPPANPPNPLDPANMEGMMDGMKKQMVMMIPQTVIMGWINAFFFGFVCVKLPFPLPNGFKQMLQRGIETRDMDISWVSSLSWYFLNLFGLNPLYRLILGDGNAADGTASLAMGGASNMAAVMPGQQVDYKKLYQTEVENLKLVDHQYVCDPIVNLQLDDIETRILKMYKN
The following text describes a protein:
Function:
Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
QFQKKGEIAAVRAGLGRLLRGRIEAIKYLTEALQSISELELEDKLEKIIDAVEKQPLSSNMIERSVVEAAVQECSQSVDETIEHVFNIIGAFDIPRFVYNSERKKFLPLLMTNHPAPNLFGTARDKAEMFRERYTILHQRTHRHELFTPPVIGSHPDESGSKFQLKTIETLLGITTKIGDVIVLGMITQLKEGKFFLEDPTGTVQLDLSKFHSGLYTEACFVLAEGWFEDQVFHVNAFGFPPTEPSSTTRAYYGNINFFGGPSNTSVKTSAKLKQLEEENKDAMFVFLSDVWLDQVEVLEKLRIMFAGYSPAPPTCFILCGNFSSAPYGKNQVQALKDSLKTLADIICEYPDIHQSSRFVFVPGPEDPGFGSILPRPPLAESITNEFRQRVPFSVFTTNPCRIQYCTQEITVFREDLVNKMCRNCVRFPSSNLAIPNHFVKTILSQGHLTPLPLYVCPVYWAYDYALRVYPVPDLLVIADKYDPFTTTNTECLCINPGSFPRSGFSFKVFYPSNKTVEDR
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
AFREVSDGSQDKDPSTLWLSVMCHLRQAEVYNPCPDSRNRRKYSPGPSRPQNCQVDLEGTQAKKSRSSNDGYTLKPSGPTQTCSSSLPSATNIPCLPPLTFGEAFEEAYQVILILDDREQFATKGSRSRKIVDYICSEFKIKIEVRRLPVGDCIWIARHKCLGTEYVLDFIVERKNIDDLRSSIRDNRYRDQKLRLQRSGFKKLIYVVEGDPNQSDAAESIKTACFTTEILEGFDVLRTSGLGETLRKYGHLTKSIHQYYKSLVNDDDGQNKAASYPCFDGFVKRCQDLDKMTISDVFAIQLMQVPQVTEEIAIAVLDMYPTLVSLASSYSQLDGNVSAQEEMLRNRSNSVISATASKNIFKLVWAE
The following text describes a protein:
Function:
Controls the length of the flagellar hook.
Sequence:
MNLSLLPAAATPSESEGVSSSSSIATLFSDAGMPTDFAKLLGDQLTQPGKELTAKEAAMLKSSLAAATTDTDSGKLTSSSSKLNQLLAALGDITATLPAGLTHLGLVGDAAGVKKTTANDDAQPDNGDEKRDVNALQTLLTMLPHQVAATLGADKLASGSAEQANTLSKEKLLANNNELMGKNGLISHHELISHPGLISDKNSTAKRDATALTGTERLAGATNGKTTTAPDKLTHLAAQDGESGLNTKNLPLAAQSEVSLSSASSDKTQLNLTPVTAALSSPMNTAAASSLVSAPANGYLSAPLGSQEWQQSLGQQVLMFSRNGQQSAELRLHPQELGALQISLKMEDNQAQLHFASAHSQVRAALEAAMPSLRHALAESGVQLGQSSVGSEGQWQQAQQQSQQNQQDVIARGQPTYGDVVAGPLTETPLAAPTALQSLANGQGGVDVFA
The following text describes a protein:
Function:
[Isoform 2]: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity. Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation; Essential for muscle regeneration and satellite cell maintenance in skeletal muscle.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: The UGA codons present in position 127 and 462 are either a selenocysteine or a real stop codon; MISCELLANEOUS: [Isoform 2]: The UGA codon present in position 428 is either a selenocysteine or a real stop codon.
Subcellular Localization:
[Isoform 2]: Endoplasmic reticulum membrane.
Domain:
[Isoform 2]: The N-terminus (first 61 amino acids) contains an endoplasmic reticulum addressing and retention targeting signal.
Sequence:
MGRARPGQRGPPSPGPAAQPPAPPRRRARSLALLGALLAAAAAAAVRVCARHAEAQAAARQELALKTLGTDGLFLFSSLDTDGDMYISPEEFKPIAEKLTGSCSVTQTGVQWCSHSSLQPQLPWLNUSSCLSLLRSTPAASCEEEELPPDPSEETLTIEARFQPLLPETMTKSKDGFLGVSRLALSGLRNWTAAASPSAVFATRHFQPFLPPPGQELGEPWWIIPSELSMFTGYLSNNRFYPPPPKGKEVIIHRLLSMFHPRPFVKTRFAPQGAVACLTAISDFYYTVMFRIHAEFQLSEPPDFPFWFSPAQFTGHIILSKDATHVRDFRLFVPNHRSLNVDMEWLYGASESSNMEVDIGYIPQMELEATGPSVPSVILDEDGSMIDSHLPSGEPLQFVFEEIKWQQELSWEEAARRLEVAMYPFKKVSYLPFTEAFDRAKAENKLVHSILLWGALDDQSCUGSGRTLRETVLESSPILTLLNESFISTWSLVKELEELQNNQENSSHQKLAGLHLEKYSFPVEMMICLPNGTVVHHINANYFLDITSVKPEEIESNLFSFSSTFEDPSTATYMQFLKEGLRRGLPLLQP
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSGEYVYGNFAAQYGQPQPQAYGTNAGAYGGGAPANGYGGYGAQNETYQQYGAQQAYTYEHQQPQAAPAQQQQYNQYSNGGEQSASQDAYHQHQYQQRPQAQAPSFGQPATGTVEERPAEATTRWSWSLYSMNRIDGARMVAPLGCLYSPLGSPCTQLNYAPTQCTVCGGVLNPYATLDPPSRMWGCPLCHTKNALPPQHQQANQYNLPPEMQPSSTTVEFVAHMPSRSPPTFVLVVDTCLDTDEELQGLRDFLLQSLQMIPEYANVAIVTYGTTVSVHEIAGSATYPRAMVLRGTQEMTVERLKLTLPNPGRFVAPLRNCSAYVAQLISSMSRDLWPVMKGHRPLRCTGAALSVAASLLQIVSPNTGSCILTFMSGVCTSGPGIVVDVSREKMIRVHADIRDETAAATYWSTSCAFYEKLMHRIVAQGHSLNCFVASLDQFGLAEMKTCVQSSGGVVLNAESWLEVPFRLSLHQFFARREDGTLKLGLNATIDVITSPTWKVQGVIGPCVGTGKMSASVAEYEIGLGGTCQWTTCQLDSTTTFAIYYDTASTQSNEAAKNPLRYTQIVTRYEMGQETHTRVTTLTLRQAQNPPIQDLVAAFDQETAAVLLAREAVHKTDSMPLFDVLRWLDRTVVRLVSRFGEYTKDKPDSLRLPKEFVYFPAFMYHLRRSGYLQIFNSSPDETASLRLQLLKSNVEDSIVQIQPTLYSYRMDAAPQPVPLDSTAIQPDNILLLDTFFEVLIHYGASIAAWKKASYAEHEDYTHFKKFLEVPLADAHVLVGSRYPTPRLIEVCQDDPDARILYNRINPSRSYASTDSGTYGSHEGELVYTDDASLQVFMQHLKKLAVAQ
The following text describes a protein:
Function:
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm.
Domain:
The Plus3 domain mediates single-stranded DNA-binding.
Sequence:
GVGRAAAAAAAVAVPLAGGQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELPSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTVELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEINKKELSIKEALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLNELEERAEALDRQRTKNISAISYINQRNREWNIVESEKALVAESHNMKNQQMDPFTRRQCKPTIVSNSRDPAVQAAILAQLNAKYGSGVLPDAPKEMSKGQGKDKDLNSKSASDLSEDLFKVHDFDVKIDL
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MDRKSKKSSVKGVSVTFVGNDDVMNHIMEEVADTKVRKSKVHTLAPSESEVPTPSRPVRTSRKRVNYTELKSTRPERDDKEEEEEEEMEEDESDDENEDDVLEAVSEVLLDRDGPLGTAVYSFKANKRSGKMAQVAAQSADRQQAKSTAIKRKHKRRIGQDKDDSDFSSDQSSDDDDDFGDKDDMNSDTSSERSITIKRPKRASHAATTTKKEQQTKRATAKGSSASQAKKGDGASKGATPGGGVRKSKRTAAKDDVSSMQSNMAQEYFVAHAGQALTSDHTLSRLDTPQMGSGQLAEALESAPNSYTKEMRELFEEHCALFNKWMYHLSNDFNILLYGLGSKRRLLEEFRRRQLKDYTSIVVNGYFPSLTMKSILNAISDDVIDDVCNHRNMADQLEFIEEKLDEMDEPLFILIHNLDGSMLRGSKVQSILSKLAQVNNVHILASIDHINAPLVWDQERSSTFRWMWYDVTTFDPYTDETSYENSLLVQQSGMLALSSLTHVLRSLTPNARGIFNILVEFQMEHKDDGTYNGMSFQELYQKCREAFLVNSDLTLRAQLTEFRDHKLIKSKKSLDGMELLSIPLDNSTLIEFQQQEEL
The following text describes a protein:
Function:
Transcription repressor.
Subcellular Localization:
Nucleus.
Sequence:
EELSALEGMKCKAPFKYEWGGVGYHSAIILGSELGEDDLVYVKAVFMHPTTKKMQPCPYFLEGNCKYPDEKCHYSHGYTVRLDEVQDFSDPDYSKITEGCTVLAKYKDELWYRGIVEDIIKGTEFSVKFQHCNDVLLLNLHAVYPLDEDDEDSSSESSEDEDDDDSQFTPRCLEEHNVGAAKETGSFGFWEKHTRGIGSRLMEKMGYVHGSGLGKEGEGRINPVEAMVFPPGRSLDRCMELREEAGSGNMLSVEKKLERQKAKAQHRLRQIANASERGSVFDFINSKLTKTSGQDSKGDGASHSRTKASDLGQLTREKLNVQSLQIGEEIRRAERDIIKMKQSLQRQSDRGDLASVSQIRSRLAEKEKDLDRLRASDRHIVNEQKQRKSSSKLTVF
The following text describes a protein:
Function:
Assembly protease promotes icosahedral procapsid assembly. Autocatalytic cleavage may release the capsid scaffolding protein. The protease domain catalyzes the cleavage of the capsid scaffolding protein after complete procapsid formation. Assembly protease and cleavages products are evicted from the capsid before or during DNA packaging; Scaffolding protein Nu3 promotes icosahedral procapsid assembly. Acts by binding the major capsid protein gpE and multimerizing in interaction with portal dodecamer, thereby placing gpE in a context facilitating icosahedral procapsid formation. Cleaved by capsid assembly protease C after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging.
Miscellaneous:
MISCELLANEOUS: It is uncertain wether Val-260 or Met-309 is the initiator for Capsid scaffolding protein Nu3; MISCELLANEOUS: [Isoform Capsid scaffolding protein Nu3]: Produced by alternative initiation at Met-309 of isoform.
Subcellular Localization:
[Isoform Capsid assembly protease C]: Virion. Host cytoplasm; [Isoform Capsid scaffolding protein Nu3]: Host cytoplasm.
Sequence:
MTAELRNLPHIASMAFNEPLMLEPAYARVFFCALAGQLGISSLTDAVSGDSLTAQEALATLALSGDDDGPRQARSYQVMNGIAVLPVSGTLVSRTRALQPYSGMTGYNGIIARLQQAASDPMVDGILLDMDTPGGMVAGAFDCADIIARVRDIKPVWALANDMNCSAGQLLASAASRRLVTQTARTGSIGVMMAHSNYGAALEKQGVEITLIYSGSHKVDGNPYSHLPDDVRETLQSRMDATRQMFAQKVSAYTGLSVQVVLDTEAAVYSGQEAIDAGLADELVNSTDAITVMRDALDARKSRLSGGRMTKETQSTTVSATASQADVTDVVPATEGENASAAQPDVNAQITAAVAAENSRIMGILNCEEAHGREEQARVLAETPGMTVKTARRILAAAPQSAQARSDTALDRLMQGAPAPLAAGNPASDAVNDLLNTPV