lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Miscellaneous:
MISCELLANEOUS: There are 2 genes for eL34 in S.pombe.
Subcellular Localization:
Cytoplasm.
Sequence:
MAQRVTYRRRLAYNTRSNRTRIIKTPGNNIRYLHIKKLGTIPRCGDTGVPLQGIPALRPREFARLSHNKKTVQRAYGGCLSANAVKDRIVRAFLIEEQKIVKQKLKQLSSQK
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP133 is involved in nuclear poly(A)+ RNA, tRNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.
Miscellaneous:
MISCELLANEOUS: Present with 3060 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution.
Domain:
Usually mRNA binding pumilio repeats come in 8 copies. In the 8-fold symmetry of the NPC the 8 repeats may be provided by eight copies of NUP133.
Sequence:
MSEKKVHLRLRKELSVPIAVVENESLAQLSYEEESQASLMDISMEQQQLRLHSHFDNSKVFTENNRYIVKTLQTDYSSGFSNDDELNGYIDMQIGYGLVNDHKKVYIWNIHSTQKDTPYITVPFRSDDNDEIAVAPRCILTFPATMDESPLALNPNDQDETGGLIIIKGSKAIYYEDINSINNLNFKLSEKFSHELELPINSSGGEKCDLMLNCEPAGIVLSTNMGRIFFITIRNSMGKPQLKLGKLLNKPFKLGIWSKIFNTNSSVVSLRNGPILGKGTRLVYITTNKGIFQTWQLSATNSHPTKLIDVNIYEAILESLQDLYPFAHGTLKIWDSHPLQDESSQLFLSSIYDSSCNETYYILSTIIFDSSSNSFTIFSTYRLNTFMESITDTKFKPKIFIPQMENANDTNEVTSILVMFPNAVVITQVNSKLDSSYSMRRKWEDIVSLRNDIDIIGSGYDSKSLYVLTKQMGVLQFFVKENEETNSKPEVGFVKSHVDQAVYFSKINANPIDFNLPPEISLDQESIEHDLKLTSEEIFHSNGKYIPPMLNTLGQHLSVRKEFFQNFLTFVAKNFNYKISPELKLDLIEKFEILNCCIKFNSIIRQSDVLNDIWEKTLSNYNLTQNEHLTTKTVVINSPDVFPVIFKQFLNHVVFVLFPSQNQNFKLNVTNLINLCFYDGILEEGEKTIRYELLELDPMEVDTSKLPWFINFDYLNCINQCFFDFTFACEEEGSLDSYKEGLLKIVKILYYQFNQFKIWINTQPVKSVNANDNFININNLYDDNHLDWNHVLCKVNLKEQCIQIAEFYKDLSGLVQTLQTLDQNDSTTVSLYETFFNEFPKEFSFTLFEYLIKHKKLNDLIFRFPQQHDVLIQFFQESAPKYGHVAWIQQILDGSYADAMNTLKNITVDDSKKGESLSECELHLNVAKLSSLLVEKDNLDINTLRKIQYNLDTIDAEKNISNKLKKGEVQICKRFKNGSIREVFNILVEELKSTTVVNLSDLVELYSMLDDEESLFIPLRLLSVDGNLLNFEVKKFLNALVWRRIVLLNASNEGDKLLQHIVKRVFDEELPKNNDFPLPSVDLLCDKSLLTPEYISETYGRFPIDQNAIREEIYEEISQVETLNSDNSLEIKLHSTIGSVAKEKNYTINYETNTVEY
The following text describes a protein:
Function:
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
Sequence:
MLVDSFNRVIDYIRVSVTKQCNFRCQYCMPATPLNFFDNEELLPLDNVLEFLKIAIDEGVKKIRITGGEPLLRKGLDEFIAKLHAYNKEVELVLSTNGFLLKKMAKDLKNAGLAQVNVSLDSLKSDRVLKISQKDALKNTLEGIEESLKVGLKLKLNTVVIKSVNDDEILELLEYAKNRHIQIRYIEFMENTHAKSLVKGLKEREILDLIAQKYQIIEAEKPKQGSSKIYTLENGYQFGIIAPHSDDFCQSCNRIRLASDGKICPCLYYQDAIDAKEAIINKDTKNIKRLLKQSVINKPEKNMWNDKNSETPTRAFYYTGG
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MCRACLSGENEIMSAFDSELRDMFIFCTSLELSSDDKLPQSICNKCKEQLVNAHTFKNTCIKSNTLLKQHLLSNYEIDDLDLKLDDLFKIDFDENCDESKPNSPQPLKPPELNNQKPRRQNKNFKFHCETCSEGFNLEDDLVLHRIAHPKDGIPKCTICDKLFNTLKVLKRHVRIHFKSKPFECDLCSHTFTESGSLTRHLRKHRGEKRHLCTVCGKGFYEANVLAVHMRTHTGEKPIKCEICGKRFADPNGLRSHIKSHSGEKKYSCKICNKCFSHSFVLKKHLRIHSGERPYLCPVCGKSFTQSHYVSVHMRQHTGELPYSCTVCKKRFVQNSQLEMHLRTHTGYKPYICNVCGKACARSGDLVIHMRTHTGEKPFTCTVCLKSYTTSSHLKVHLRTHNGERSHLCTFCGKSFTENQGLKAHIRTHTGEKPYICAVCGHGFAQSGALATHRKIHKVGTGLKADDEIKIENNPLY
The following text describes a protein:
Function:
Membrane-bound E3 ubiquitin ligase expressed at the immediate early stage of viral reactivation to mediate polyubiquitination of various host membrane proteins related to the immune response. Promotes ubiquitination and subsequent degradation of host MHC-I, CD86, DC-SIGN and DC-SIGNR, ICAM1 and CD1D molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. Plays a role in the down-regulation of the host stress-induced NKG2D ligands MICA, MICB and CLEC2B, which enable immune cells expressing the NKG2D receptor to recognize and annihilate infected cells prior to viral spread. Alters monocyte metabolism and proliferation by mediating rapid internalization of cellular growth factor-binding receptor tyrosine kinases from the surface leading to increased signaling.
Subcellular Localization:
Host cell membrane; Multi-pass membrane protein. Host endoplasmic reticulum. Note=Probably exerts its effects at the plasma membrane during viral infection.
Sequence:
MASKDVEEGVEGPICWICREEVGNEGIHPCACTGELDVVHPQCLSTWLTVSRNTACQMCRVIYRTRTQWRSRLNLWPEMERQEIFELFLLMSVVVAGLVGVALCTWTLLVILTAPAGTFSPGAVLGFLCFFGFYQIFIVFAFGGICRVSGTVRALYAANNTRVTVLPYRRPRRPTANEDNIELTVLVGPAGGTDEEPTDESSEGDVASGDKERDGSSGDEPDGGPNDRAGLRGTARTDLCAPTKKPVRKNHPKNNG
The following text describes a protein:
Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MSTAVEVTGFIMAVISFLVTGTSLSNDYWKISTVSGSVIISQRQFENLWHACAENSAGIAECRDFDSLLGLPAHVQACRALMIISLLLGLGCIIVALLGLKCIKIGSTTEESKAKIATTGGILSMLGGLCCIIACSWYGFQVVQDFHNPFNGGVRFELGTGLYLGWAGGALAVLGGALLCTACKRVAAAKKGGYFGKSKQKVYTATAKSDPESSRAYV
The following text describes a protein:
Function:
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
Subcellular Localization:
Secreted.
Sequence:
MQVSTAALAVLLCTMALCPLAADTPTACCFSYISRQIPQNFIADYFETSSQCSKPGVIFLTKRGRQVCADPSEEWVQKYVSDLELSA
The following text describes a protein:
Function:
Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGSSQRCDLNTVTVVGEAAEAQSEDSDDEELREARERRALVVSRWRRAYAHVLELARLGFAGDFGSGAYIEVDLRGGKTLPPQVERKLRREYRGRVEVQVVDYCLTAARPRLVRWSNYSDGATGMRALRGFLDMPRPVLSLLEPQIRWVKAEGFAWDLVKALAGRYNLPPLLVSDLLGVENTEVLENFGAGSGVGGSGGGSSDPGPAPGGAGGFDGTWASGTSMPRGRATARSGLMGRRSRNAPAQLLSRSSQLGSGSWEKSGGVYGGGNAGDGIGGGGTDGGGGSGGSGAAGCGAWWRWGRIEKEEEPQLEDPHRRIKTEYYGSDGILYISMPMIGLRTRLLLRSTIQQQQAAAAAARAELDPAPAPIAAAAAGPTVHGARVKVEAAGGPASNAVSRALEATIAAAMRPSGGGFGGMPVAEGVEAPLASDPAAAAVASAAEAASTAGNTGAQALLARPLAPASTSVFAQNPLMSFAAAGVDPAAAAATAGHVGASSGDGGHAGLTDLGAAAAPTATRAGAATTHVTATAAGTRGPLAGAAGAALVTGASAGAAPATLVDTGTGTAAGRHHGAGGVGVGVDVGVAVGSGDVGVSSIGHPQHHPGHVHHHGHGGQRRSSELQGWGSVASGGSVADVGVETDSPRSLEAWLRWLRGLCRCGRPPSRGRKDAGLWQRLMGVRRSRDDEYRYEKRWVEEPLVLMLVQDKAVHGATPHAPPNLPVAAGPAIAAGGGGGGGGHGTGARGVTLISVFHYSGRSVTYRLWRQITSGATGSTAAAAAAAAAVAAAATAASFSHTKSGHHSTKSAAETPKSAVAVATAATGVTAGGTGTALPPHPPGVGADAGGRGGVPSGLTPQLLNRISTSTVAGAPHSLLSEVRRSDAGYLLYLIMRGAVDQAYDVVRDFYAQLSEFERRVRSGNLSATATEQLHVMSTDLQLLDRRFKATITVLRLLTTKDAKDDSGTLTDAPMQLSANTQAKIKALVEQVRGISDEIDSLGTQASQLTDLVFNLIAHRSNNSMRVLSIISTVFLPITFLAGVYGTNFDNLPELHWQLGYMYFWLLMTGVGIVVLAIANKYVH
The following text describes a protein:
Function:
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil. Probably interacts with both lipid and phospholipid moieties of lipid bodies. May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.
Subcellular Localization:
Lipid droplet. Membrane; Multi-pass membrane protein.
Sequence:
MTDIHTKEQGQQQSRWHVEPQHQSQHWTTQSQRQWNEPRAHQVVKAATAAAVGGSLLVLAGLVLAGTVIALTLATPVLVIFSPVLVPALIAVFLLVSGFLTSGGFGVAAATVLAWMYRYVTGEQPSGADTSDEVSHRLGAKARDIKDRGEHAGRGGHYGTAGVHTGGPGGGVGTYV
The following text describes a protein:
Function:
Responsible for the release of ribosomes from messenger RNA at the termination of chloroplastic protein biosynthesis.
Sequence:
MLSRGGRRGVCLLAQALSHDAGRGWGVLASDNLPKGFRSWPGSHLADAAPVTTAVGTWSMYGQAAFFASKGGKQGGKGAKEAVQAPQEVQEWDIEPFVTQMGEALDHLRRKLAGIRTGRASPGLLEAVSVEARSSGSSHGPHVPLRVLGTVVARGPQLLVVELYDKEDDKAVAKAIQNSPLKLQARAENGEVLVPVPRLSLEMVKGFVKLAAQEAEAARKAVRAVRHRALEQAKLCNTGGPAGELKRMEQQVQALTDKHIREVDGLLRAKERDLQEHH
The following text describes a protein:
Function:
Required for the localization of acetylcholine receptors at neuromuscular junctions and for subsequently controlling the response evoked by receptor stimulation.
Subcellular Localization:
Synapse. Secreted. Note=Secreted by body wall cells. Co-localizes with and requires acetylcholine receptors for localization at neuromuscular junctions.
Sequence:
MSFRLWGRCIFFFCFLLEAIDSRGGRRGGKGKGKSNLQFAQVAEFSLVQTVLSDNRSAQIITGSHFSQTYRLGYKLLIICKARGDPRPTIKWYKEGAEIQPKASIHYYEKPIENDTIWSKLEVDPATMGDQGVYACVANNPHGVMAKNFKAEYTY
The following text describes a protein:
Function:
May be involved in the modulation of rDNA transcription.
Miscellaneous:
MISCELLANEOUS: Present with 51100 molecules/cell in log phase SD medium.
Sequence:
MTEQVNNDTTSDTTTTITTVYISNLPFTASERDLHAFLNNYGASSVLIPTQTVRRFSKRHNSNPRKPLGIAFAQFANNTLALKAIQDLNGTVFQNQKLFLKLHVPYEADSTPDTDVKKPKEKNKVKKTPETAADTVYCHDLPDDITDSEIRELFQLYSPQEIWIYRSKVYRRKCIPFAPHQITAALVTLQSETPIGDICDSVAKTATLRGKSIIVKPAYVSKIQEIKQLVKDNLTNARDPPPAALAEPAPAPAPVEPAEQVQEGQDNAETNDVPPPPASSSDRPTVAAT
The following text describes a protein:
Function:
N-acetyltransferase that acts on a wide range of D-amino acids. Catalyzes the N-acetylation through an ordered bi-bi mechanism, in which acetyl-CoA is the first substrate to be bound and CoA is the last product to be liberated. D-amino acids are toxic for the cell and their N-acetylation, preceding removal from cells, plays an important role in detoxification of D-amino acids. In vitro, capable of acetylating histone H4 at 'Lys-8' and polyamines like putrescine, spermidine and spermine.
Miscellaneous:
MISCELLANEOUS: Present with 1200 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSNEEPEKMVNDRIVVKAIEPKDEEAWNKLWKEYQGFQKTVMPPEVATTTFARFIDPTVKLWGALAFDTETGDAIGFAHYLNHLTSWHVEEVVYMNDLYVTERARVKGVGRKLIEFVYSRADELGTPAVYWVTDHYNHRAQLLYTKVAYKTDKVLYKRNGY
The following text describes a protein:
Function:
Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MGVPTALEAGSWRWGSLLFALFLAASLGPVAAFKVATPYSLYVCPEGQNVTLTCRLLGPVDKGHDVTFYKTWYRSSRGEVQTCSERRPIRNLTFQDLHLHHGGHQAANTSHDLAQRHGLESASDHHGNFSITMRNLTLLDSGLYCCLVVEIRHHHSEHRVHGAMELQVQTGKDAPSNCVVYPSSSQDSENITAAALATGACIVGILCLPLILLLVYKQRQAASNRRAQELVRMDSNIQGIENPGFEASPPAQGIPEAKVRHPLSYVAQRQPSESGRHLLSEPSTPLSPPGPGDVFFPSLDPVPDSPNFEVI
The following text describes a protein:
Function:
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E1A protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome. Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore. This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBXW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation. The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta). Promotes the sumoylation of host ZBED1/hDREF with SUMO1.
Subcellular Localization:
Host nucleus.
Sequence:
MRHIICHGGVITEEMAASLLDQLIEEVLADNLPPPSHFEPPTLHELYDLDVTAPEDPNEEAVSQIFPDSVMLAVQEGIDLLTFPPAPGSPEPPHLSRQPEQPEQRALGPVSMPNLVPEVIDLTCHEAGFPPSDDEDEEGEEFVLDYVEHPGHGCRSCHYHRRNTGDPDIMCSLCYMRTCGMFVYSPVSEPEPEPEPEPEPARPTRRPKMAPAILRRPTSPVSRECNSSTDSCDSGPSNTPPEIHPVVPLCPIKPVAVRVGGRRQAVECIEDLLNEPGQPLDLSCKRPRP
The following text describes a protein:
Function:
Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility. May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, axon. Cell projection, dendrite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with microtubules from neurites, centrosomes, basal bodies and axonemes.
Sequence:
MAALPVPLPPTKMAAVEKRRPAVAPAANFPDSGRTSVSQAAAAAESEEDFLRQLGVTEMLRAALLKVLEIRPEEPIAFLAHYFENMGLRSPTNGGAGEPPGQLLLQQQRLGRALWHLRLAHHSQRTAFNNNVSVAYECLSASGRKKKPGLDGRTYSELLKRVCRDGGAPEEVVAPLLRKIQCRDHEAVPLGIFRTGMLSCFVLLEFVARAGALFQLLEDPGQAVADRRVGQAVLDTLEGALSAGDMATAPTHYLEAGSRLGPDNLARALDRAASGRRPSVPMAREEFLEKAAALFIAKVKPVG
The following text describes a protein:
Function:
Putative antitoxin component of a type II toxin-antitoxin (TA) system; however the expected toxin coding sequence is not found adjacent to this gene.
Sequence:
MGTRSKSRTRQLKQSNGCTATTSGASDRRRRARRRTAPAWLREDEWLRHHLPHPPRQLSRCLHRRRRSACHHRYSRRTPKGGLPMTSSLVPISEARAHLSRLVRESADDDVVLMNHGRPAAILISAERYESLMEELEDLRDRLSVHEREHVTMPLDKLGAELGVDIGRV
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAQGHISLSGGPAGGPSALHPPPDPADASPRRGRREEARPAAAGNWNPRLWDWDRRALTARPSADALRLAGGQPHQATEVHRQGAGGSGALKFQLGPRECSATPTDASPTSSPPASGQDLVVRPSKRVRSGSPGSVGGGGAANGGAGYPMFQSELIHVPPPPCSRPRYVMAPPLVFTSIGASMNAAVRDVWASNFDEELSNLSAVLPRYPCVCLDTEFPGAVHDSDMPRYMRGPRESYELVKRNVDDLKLLQVGIALSGPAGRFPIAWQFNIRGFDPALHPHAPASIAMLREQGMDFALLNEFGIDPEDFAAGFRRSGLACGWLSWTAFSGSYDFGYLAKALTGSQPLPDTLDGFLALVATALGVKRAAGRAHCAGSDSLLTTDVLLLMMDRFFRNVDVLAHAGTIVDLT
The following text describes a protein:
Function:
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular Localization:
Cell membrane.
Sequence:
MLTASLLRAVIASICVVSSMAQKVTQAQTEISVVEKEDVTLDCVYETRDTTYYLFWYKQPPSGELVFLIRRNSFDEQNEISGRYSWNFQKSTSSFNFTITASQVVDSAVYFCALSE
The following text describes a protein:
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MDALDSAVDPLREFAKDSVRLVKRCHKPDRKEFTKVAIRTAIGFVVMGFVGFFVKLIFIPINNIIVGSG
The following text describes a protein:
Function:
Involved in the production of itaconic acid, a soluble unsaturated dicarboxylic acid mainly produced from sugars.
Subcellular Localization:
Mitochondrion.
Sequence:
MTKQSADSNAKSGVTAEICHWASNLATDDIPSDVLERAKYLILDGIACAWVGARVPWSEKYVQATMSFEPPGACRVIGYGQKLGPVAAAMTNSAFIQATELDDYHSEAPLHSASIVLPAVFAASEVLAEQGKTISGIDVILAAIVGFESGPRIGKAIYGSDLLNNGWHCGAVYGAPAGALATGKLLGLTPDSMEDALGIACTQACGLMSAQYGGMVKRVQHGFAARNGLLGGLLAYGGYEAMKGVLERSYGGFLKMFTKGNGREPPYKEEEVVAGLGSFWHTFTIRIKLYACCGLVHGPVEAIEKLQRRYPELLNRANLSNIRHVYVQLSTASNSHCGWIPEERPISSIAGQMSVAYILAVQLVDQQCLLAQFSEFDDNLERPEVWDLARKVTPSHSEEFDQDGNCLSAGRVRIEFNDGSSVTETVEKPLGVKEPMPNERILHKYRTLAGSVTDESRVKEIEDLVLSLDRLTDITPLLELLNCPVKSPLV
The following text describes a protein:
Function:
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (By similarity). Regulates tissue growth possibly by regulating Ras64B protein stability. May regulate CG34450 mRNA levels.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MPKCDVKTRYIPATFAWIVLLLTTFLFFFYPCQFYVKSHPWVLAYQGVITFFVLANFTLATFMDPGIIPKASPDEDCEEELRAPLYKNAEINGITVKMKWCVTCKFYRPPRCSHCSVCNHCIETFDHHCPWVNNCIGRRNYRFFFFFLVSLSIHMLSIFSLCLVYVLKIMPNIKDTAPIVAIILMGLVTILAIPIFGLTGFHMVLVSRGRTTNEQVTGKFKGGYNPFSRGCWHNCCYTQFGPQYPSLLNPKKYASRRSQVQNQAISTICNDRSGQQTGAGSGAGGNGTAAVSGGGGGVGSGGGMRGTAVQYSPRSFYDASREKRGIQVKTYMAEGNGYNQRSGSTTLYSKLSPGRECSDTDLEPPPASQSQDCEPTPPLQRHNSSSFYLPQVSDSGGLNGSVSTGGGGGGDSPRHMRLYHPRHSPHARPRGLDPQRGYTSDALSPDHPVGYGVGVNGSQQQQQQALAAAAAAAAVAAQNQRSATTTATPTMQQRIKPLGVATPLVMASPVRRSNPGTPTQPRRPDFIGLNAQAVAQQQQQQQQAAAAAAAAYYEYTSGLPPQHPQAPSIQQQQQQLLLQQQRVLMQHQQQQQALQQQQQQQQQAAVHAAHPQHAALAQAAYGGSPQRRFLSEGELVRQGAGGGVAGGELSYARSNNTVDNIRELAGSPQRGVYMWKDTSPGFTNNAGQQQQQQQQAQQVVSSGIGSSAGTLSSSGAAAGVMPHAQYMTAGGGAHPLIMTHSRLQDYTIQQQQQQQQQQAAAAAAASYHRSNPTSPTTMPQVSGAGQSYILRYGGGGAVGAAGSSGSLASVTASNPATGGGGYQPALRGGVAVFPPNPMGNQGGGNLQTQPSPQIKRKQTPTRPMSFVRALEMADSMEMQSLEQQQNGGIPGSGSVGNNQQAGGGGGGHLMQSNASNSGTPDRASIYDMNYEISV
The following text describes a protein:
Function:
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Subcellular Localization:
Nucleus.
Sequence:
METFAGCYILRSQNPQYKTHCYIGFTVNPPRRIKQHNGARVGGAFKTHTMRPWEMTLVVWGFPTKKLALKFEWTWQHPTEAKSLKHINFEEFYQREGGPRKYNTNLKILKEMLLSQQWNRLSLRICVQCKDVYEMLLQPPVLPQHIKIELGSINDLPIDSHGFPSPGEYGNTPCPLCNESEPPYNMNWVVCPFCGTLMHLKCMALRLISQSPSAGTALIPTHGSCPSCKENIIWRDLVELRNQIQDEEE
The following text describes a protein:
Function:
Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Subcellular Localization:
Secreted.
Sequence:
MYREWVVVNVFMMLYVQLVQGSSNEHGPVKRSSQSTLERSEQQIRAASSLEELLRITHSEDWKLWRCRLRLKSFTSMDSRSASHRSTRFAATFYDIETLKVIDEEWQRTQCSPRETCVEVASELGKSTNTFFKPPCVNVFRCGGCCNEESLICMNTSTSYISKQLFEISVPLTSVPELVPVKVANHTGCKCLPTAPRHPYSIIRRSIQIPEEDRCSHSKKLCPIDMLWDSNKCKCVLQEENPLAGTEDHSHLQEPALCGPHMMFDEDRCECVCKTPCPKDLIQHPKNCSCFECKESLETCCQKHKLFHPDTCSCEDRCPFHTRPCASGKTACAKHCRFPKEKRAAQGPHSRKNP
The following text describes a protein:
Function:
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Sequence:
MTDIPADDPKIELRSDITVELVKSAATDSDVLFAARVSTAGEQSLDELKKDPERSKGLINYLMRDRHGSPFEHNSMTFFVSAPIFVFREFMRHRVGWSYNEESGRYRELQPVFYAPDASRKLVQQGRPGKYVFVEGTPEQHELVGSAMEDSYRQAYATYQQMLAAGVAREVARAVLPVGLYSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMAGEKMEAEWARLMPLTHAAFNANGRVAP
The following text describes a protein:
Function:
Voltage-gated chloride channel involved in skeletal muscle excitability. Generates most of the plasma membrane chloride conductance in skeletal muscle fibers, stabilizes the resting membrane potential and contributes to the repolarization phase during action potential firing. Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Has a significant open probability at muscle resting potential and is further activated upon membrane depolarization. Permeable to small monovalent anions with ion selectivity for chloride > thiocyanate > bromide > nitrate > iodide.
Subcellular Localization:
Cell membrane, sarcolemma, T-tubule; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MEPSESQRRRGEQSWWGSAPQYQYMPFEHCTSYGLPSENGGLQHRLWRDAGHHPNAHPTQIYGHHKEQFSDKKQDMGMPKKTDSSATMDSKDEDHSSKCQDCIHRLELVVRRKLGEDWIFLVLLGLLMALVSWSMDYVSAKSLQAYKWTYYQMQPSLPLQFLAWVTFPLILILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTLKAFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYETVPGRLDLLVSACAVGVGCCFAAPIGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLQELPAFAIIGICCGFLGAAFVYVHRQVMLGVRKHKALSQFLAKHLLLYPGIVTFVIASFTFPPGMGQFMAGELMPREAISTLFDNNTWVKHVGDPESLGQSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDGIIYKILPGGYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSKFTIFVEDIMVRDVKFVSASCTYGELKTLLQTTTVKTLPLVDSKDSMILLGSVERSELQSLLQRHLCPERRLRAAQDMARKLSELPYDGKARQTRGGHRSISSQGRPESFAFVDEDEDEDLSGKPEVPPLPPPHPFPTAPLASEEPNGPLPSHRQQPEAPEPAGPRPSIFQSLLHCLLGRARPKKKKTTQDSTDLVDNMSPEEIEAWEQEQLSQPVCFDCCCIDQSPFQLVEQTSLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAIEGHTKSGVQLRPPLASFRNTTSIRKNPGGPPPPTEAWSLPEDGTRATEADDVPPASPETPVPPPSQEHPLSLAPAKVESDLEELELVESPGPEEELADILQGPSLRSTDEEDEDEVIL
The following text describes a protein:
Function:
Catalyzes the conversion of dTMP to dTDP (Probable). Involved in the regulation of DNA replication. Is essential to promote the first division of the zygote.
Subcellular Localization:
[Isoform 1]: Mitochondrion; [Isoform 2]: Cytoplasm. Nucleus, nucleoplasm.
Sequence:
MKRICSVSSVQLFSRSFRALASPRSLNYPLQCIKRSSVRMESSNFSSGVRTESSVKPRGALIVLEGLDRSGKSTQCAKLLSFLNGLGHPTELWRFPDRETSVGQMISAYLSNKSQLDDHTIHLLFSANRWEKRSLMEEKLKTGTTLIVDRYSYSGVAFSSAKGLDIEWCKAPEIGLLAPDSVLYLDISPERAAERGGYGDERYERVEFQKKVADFYQTLGDSSWKIINASDAMEEVEKKIQQVVLDQVKECTEGKPLSLLWSS