lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Subcellular Localization:
Cytoplasm. Mitochondrion matrix.
Sequence:
MAAAATTTTTFQRTPTLHLPLTPNRFTSYSKFSSASFQRSRQSWPTQLPLMSSNSSISPSYKLSRLPVGFFFCSASSHDETLVTEDEKGVATEEFQSQPEDTEDATVEVDSSESDGSEVEESPASILASLQSYKEALADNNESKIAEIESHLKSIEDEKLVLERQVATLSDELSTAKDRVLRISADFDNFRKRTERERVTLVANAQGEVVESLLAVLDNFERAKAQIKVEGEKEEKINNSYQSIYKQFVEILGSLGVVSVETTGQPFDPLLHEAIMREESTEYEEGVVIQEFRKGFRIGERLLRPSMVKVSAGPGPGNTESVGPSEPEGQAPEEEEEVQSESSAAQEE
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes; Regulates also the sphingolipid metabolism.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MPICIECSYPVSHLYSAYSRADDRSLGKGVRLTQCPRCKRFADKYVEYDFVVIFIDLVLIKPQVYRHLLFNRLESDEHKFDRSIIRLGVLLLLFDVYLTWARIEKSPLIETTFLSRAPIIIQYLFFLTLNALATLAHHLTVRLLASFITFSSQSTPTKQPTATANAAATESQAPVPSNPTTPILPSFPQQLVQAQQASALSPPKSTPHSSVQELPGLENQRPRQPSPSSPRDSFCDLRPPLRRASTGPMQSFQQLSPPSQASPTAISTALFVSSCAKLFPILLVIWGPDGRISSSNSTPSSGYGASAVSTLQPNPAQRAEGGSDLVVAGSAGSGLAESSPSVSSSLLEGLSAADMHLVLLSNIEALYILLGCGYLRATALAVAGLLARWAVQKVILGVVGVDNLRLCGQSM
The following text describes a protein:
Function:
May participate in intramanchette transport and midpiece formation of the sperm tail. May play a potential role in somatic cell proliferation.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, flagellum axoneme. Note=During spermatid elongation (step 10), localizes along the length of the manchette and later during the elongation process only at the distal ends of spermatid manchette (step 12). In late elongated spermatids (step 16), in the final steps of spermiogenesis, localization is restricted to the midpiece of the flagellum. Localizes at the contractile ring in dividing cells (By similarity). Predominantly perinuclear in bronchial epithelial cells but also detected in the nucleus in some primary epithelial cells and in a number of cell lines.
Sequence:
MFLFSRKTRTPISTYSDSYRAPTSIKEVYKDPPLCAWEANKFLTPGLTHTMERHVDPEALQKMAKCAVQDYTYRGSISGHPYLPEKYWLSQEEADKCSPNYLGSDWYNTWRMEPYNSSCCNKYTTYLPRLPKEARMETAVRGMPLECPPRPERLNAYEREVMVNMLNSLSRNQQLPRITPRCGCVDPLPGRLPFHGYESACSGRHYCLRGMDYYASGAPCTDRRLRPWCREQPTMCTSLRAPARNAVCCYNSPAVILPISEP
The following text describes a protein:
Function:
Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
Sequence:
MAAAVALCPAPVKAHKPPYSALASRHFFSTSLIVKYQEVQKWNRFEFQRLQVSSAAVNDNAVTVTDSSRPSIRSTVMRHTISVFVGDESGIINRIAGVFARRGYNIESLAVGLNKDKALFTIVVTGTENVLRQVVEQLNKLVNVIKFPCLFRVAVDIGNSWVIVGVVFDLGRAFIEEIQVG
The following text describes a protein:
Function:
Involved in the catabolism of purine nucleotides. Can use (S)-2-ureidoglycine as substrate, but not allantoate. The sequential activity of AAH, UGLYAH and UAH allows a complete purine breakdown without the intermediate generation of urea.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MRSLYLIVFIVISLVKASKSDDGFCSAPSIVESDEKTNPIYWKATNPTLSPSHLQDLPGFTRSVYKRDHALITPESHVYSPLPDWTNTLGAYLITPATGSHFVMYLAKMKEMSSSGLPPQDIERLIFVVEGAVTLTNTSSSSKKLTVDSYAYLPPNFHHSLDCVESATLVVFERRYEYLGSHTTELIVGSTDKQPLLETPGEVFELRKLLPMSVAYDFNIHTMDFQPGEFLNVKEVHYNQHGLLLLEGQGIYRLGDNWYPVQAGDVIWMAPFVPQWYAALGKTRSRYLLYKDVNRNPL
The following text describes a protein:
Function:
Involved in the conversion of chorismate to salicylate.
Sequence:
MSRLAPLSQCLHALRGTFERAIGQAQALDRPVLVAASFEIDPLDPLQVFGAWDDRQTPCLYWEQPELAFFAWGCALELQGHGEQRFARIEENWQLLCADAVVEGPLAPRLCGGFRFDPRGPREEHWQAFADASLMLAGITVLREGERYRVLCQHLAKPGEDALALAAYHCSALLRLRQPARRRPSGPTAGAQGDASAQERRQWEAKVSDAVSSVRQGRFGKVVLARTQARPLGDIEPWQVIEHLRLQHADAQLFACRRGNACFLGASPERLVRIRAGEALTHALAGTIARGGDAQEDARLGQALLDSAKDRHEHQLVVEAIRTALEPFSEVLEIPDAPGLKRLARVQHLNTPIRARLADAGGILRLLQALHPTPAVGGYPRSAALDYIRQHEGMDRGWYAAPLGWLDGEGNGDFLVALRSALLTPGRGYLFAGCGLVGDSEPAHEYRETCLKLSAMREALSAIGGLDEVPLQRGVA
The following text describes a protein:
Function:
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MEPSPLELPTDTLRRIASELRCHPTDERVALRLDEEDKLRHFRECFYIPKMQDLPPIDLSLVNKDEEAIYFSGNSLGLQPKMVKTYLEEELDKWAKMGAYGHSVGKRPWIIGDETISGLMADIVGANEKEIALMNGLTVNLHLLLLSFFKPTPKRYKILLEAKAFPSDHYAVESQLQLHGLNIEKSMRIIKPREGEDTLRLEDILEVIENEGDSIAVILFSGLHFYTGQLFNIPAITKAGQAKGCFVGFDLAHAVGNVELHLHDWGVDFACWCSYKYLNTGAGGLAGAFVHEKHAYTIKPALVGWFGHELSTRFQMDNKLQLIPGVNGFRISNPPILLVCSLHASLEIFKQATMKALRRKSILLTGYLEYMIKQYFSQDKAESKKTVVNIITPSCIAERGCQLTLTFSIPIKHIIQELEKRGVVCDKREPDGIRVAPVPLYNSFHDVYKFINLLTSVLGSVET
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MAIFFPIFTFFFFLTHAQNAPQDYISLHNKARAAVGVGPMTWNNTVAAYAQSYANKRKNDCALIHSTGPYGENIAVGYYPEFTGADGVKMWVGEKHLYDYASNSCKGGDCGHYTQVVWRTSVHLGCARVACKGKSQFVFSPLPPNDDHTQNKQDETKYSDQNDNNLLLRFFRLLFPAHWQKKNDDFFGVSALRCFSNKKATTHERNSKHYFRLSPPSITELCESGVTIKAKENEDFCFMNIGFKDGVLEIPYINIDSTFEVVIRNVIAFDQYPAENKEKYAIHYVLFLDDLINTEQDAHLLAKAGVIINTLGGNGKDITKMFNCSLNL
The following text describes a protein:
Function:
Involved in the digestion of the blood meal.
Subcellular Localization:
Secreted.
Sequence:
MCLKLILISASILSVVAPSSVHERDEVLRIFPRNAEDVRFLTTMDEEQGLSLDFWKFPSGPDNIADVHVQKAHLPLVKDALKRQGIPFNVLVDDVGEALHQHMRTNRMSRALSRMRRDENFDFSVYHTYKEITDHMRHLATNYPDIASIMSVAGTYEGRSIMTIKLGKPFSNGTVKPAFWIDGAIHSREWIVPATIIYAVDRLVRQYGSDPTVTRILDGLDLYVTPVFNVDGYVYTWQSDDTRLWRKNRAPQAGPCVGVDMNRNWDSHWSEGGSSHDPCNWAYHGTAPFSEQETREISTFIWENRRDIRAYIAFHSYSQVWMAPWGHSYNRPPGDAGAQDALGRLAVETIKSVHGVDYVAGRAMETLYQVSGDSQDWTYDKAGIKYSYIAELRDTGRYAFLLPPDQILPTAEEIFPSILTVGEWILDHY
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGSKEGKVFHGRVSMAISDFNSFGRDNQMRIVLHTRDSKGDLLLALSSAFNLWENNKVKVILSAQKSTLEAKFLAEFGNNTKIPVIPISAPYLIQAPPHDHAEVKGIVASAELHKWEKVILIYEDHNDNHWSDFFEEKKFQVAYKSSVAASSKDEHIIEELHRLKAMETSVLVVHVEPVLASRIFVHAKRLGMVSQGYAWIVTSKCMNHLQNLKDYSSILENMQGFIGFRSYNIKESKEFDMLQLMNFTQMVNFGIVNVLGTEGERRVGFWTGKFTNKLSHGFTHGRHLFSSSGFETIIWPGGTSTIPKGRRMQTSTKTLRIAVPKSNGFPQLLKVDIDLQTNITFSGFCIEVFKAAMAGLEHTVPYEFVSFEYNNPNIGEAYSDLVYQLYLQTYDAIAGDITITANRSLYVDFTLPFTEMGIGMVTRLPPKESQNLWIFLKPLSSGLWLTIVGVYVLSALFIWLIERPAFVERQTRQSNGEIGRMFGFSFSIFVFTHSLLPSPPQLLRLLSPKLLL
The following text describes a protein:
Function:
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAQLEGYYFSAALSCTFLVSCLLFSAFSRALREPYMDEIFHLPQAQRYCEGHFSLSQWDPMITTLPGLYLVSVGVVKPAIWIFGWSEHVVCSIGMLRFVNLLFSVGNFYLLYLLFRKVQPRNKAASSIQRVLSTLTLAVFPTLYFFNFLYYTEAGSMFFTLFAYLMCLYGNHKTSAFLGFCGFMFRQTNIIWAVFCAGNVIAQKLTEAWKTELQKKEDRLPPIKGPFVTFRKILQFLLAYSMSFKNLSVLFRLTWPYILLGFLFCAFVVVNGGIVIGDRSSHEACLHFPQLFYFFSFTLFFSFPHLLSPGKIKTFLSLVWKRRILFFVVTLVSVFLVWKFTYAHKYLLADNRHYTFYVWKRVFQRYEIVKYLLVPAYIFAGWSIADSLKSKSVFWNLMFFICLFIVIVPQKLLEFRYFILPYVIYRLNIPLPPTSRLVCELSCYAIVNFITFYLFLNKTFQWPNSQDIQRFMW
The following text describes a protein:
Function:
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
Sequence:
MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLVTASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTVNNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEISEDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK
The following text describes a protein:
Function:
Acts in the sexual differentiation pathway. Is required for efficient conjugation. Double-stranded DNA-binding protein.
Subcellular Localization:
Nucleus.
Sequence:
MESESVPTVPQTTRPGPRCYNCGENGHQARECTKGSICYNCNQTGHKASECTEPQQEKTCYACGTAGHLVRDCPSSPNPRQGAECYKCGRVGHIARDCRTNGQQSGGRFGGHRSNMNCYACGSYGHQARDCTMGVKCYSCGKIGHRSFECQQASDGQLCYKCNQPGHIAVNCTSPVIEA
The following text describes a protein:
Function:
A methylase, recognizes the double-stranded sequence 5'-YTCGAR-3', methylates C-3 on both strands, and protects the DNA from cleavage by the BsuMI endonuclease.
Sequence:
MKVVSLFSGIGGIELGLHQSGHTTEIFCEVDPLAKAVLSKNFPGVKIEDDINEIRELPSCDLVAAGFPCQDLSQAGGKEGIDGSRSGLVKKLFELIEKKEHANRPPWILIENVPYMLRLNRGKAMSYLTSVLSELGYTWAYRTVDARCFGLPQRRHRVILLASLFEDPKDVIFSQDHSEPDLDGKPSVVDHSNYYGFYWTEGLRGVGWAREAVPPIKCGSSVGIASPPAVWSPYEDIVGTINIRDAERLQGFPEDWTNITTETGKDIKEGARWRLVGNAVSVRVSKWIGENLSQPKGSISDFEGELVTKTWPSAAWGYGDKKYKVPVSKWVANTEQIAISEFLNHPLKPLSARALNGFLGRAARCTNVNYSDEFINSLERCKDRQLQKV
The following text describes a protein:
Function:
Functions with the transcription factor TfAP-2 to regulate octopamine neuronal signaling pathways that control behaviors such as male aggression, male mating, and the initiation of feeding. Required for TfAP-2 transcriptional activity in octopaminergic neurons. Functions with TfAP-2 to regulate expression of genes which are involved in promoting octopamine production and secretion from octopaminergic neurons, such as Tbh and Vmat. Octopamine then modulates feeding and male aggression by regulating the expression of the satiation hormone Dsk in insulin-producing cells (IPCs). Functions with octopamine and Dsk as part of a negative feedback loop to prevent overeating; acts with TfAP-2 to regulate octopamine signaling pathways that initiate feeding, then octopamine activates expression of Dsk which inhibits consummatory behavior. May also be involved in negatively regulating nociception in larvae to prevent spontaneous pain and hyperalgesia.
Sequence:
MQVRTPFVALDQRSPLTVDSSCPKRKKCDMDRERERDVKALEPRDLSSTGRIYARSDIKISSSPTVSPTISNSSSPTPTPPASSSVTPLGLPGAVAAAAAAVGGASSAGASSYLHGNHKPITGIPCVAAASRYTAPVHIDVGGTIYTSSLETLTKYPESKLAKLFNGQIPIVLDSLKQHYFIDRDGGMFRHILNFMRNSRLLIAEDFPDLELLLEEARYYEVEPMIKQLESMRKDRVRNGNYLVAPPTPPARHIKTSPRTSASPECNYEVVALHISPDLGERIMLSAERALLDELFPEASQATQSSRSGVSWNQGDWGQIIRFPLNGYCKLNSVQVLTRLLNAGFTIEASVGGQQFSEYLLARRVPM
The following text describes a protein:
Function:
May play a role as a mediator of inflammation and angiogenesis.
Sequence:
MLKMVTFFQGLPGQQSVPGTLDLPGSPQKPRSTSEAESETSMSEASSEDLMPSQEAPEGEEESAKKKEKKSKGLANMFSVFTKGKKKKKDQPRLSDPEVQSKSRPEEDGPLPTVEELKEALELGRLEVAWQVLALERQLEAAAAAGGTSDEELVWRQSKVEALYVLLRDQVLRVLRRPLEAAPERLSQALAVVSQEELEDRRASRGPLATALAITRPRRWLQLWRGVVAEVAAERLDAQPAFVPEGRSEAENRFLHMGRTMREDMEVVVERLKPLFPEEFNVVHTYAESYHEHFATHLCTLAQFELCERDTYLLLLWVQNFYPNDILNSPKLAQELQGIRLGSLLPPKQIRLLEAVFLSNEVTNVKQLMTRALELESQRWAQDVAPQSLDGRRHSELAIDILQAQSRAGWAAMLTHCSLQIISQGQTKAENITSDVGMQIKQLLLVELAALLRSYQRVFDEFLEKSKLLRNYRVNIIANINNCLSFRTSVEQRWQIPQDSLNRLVEPLKDLKAHGFDTLLQSLFSDLKPLFKKFTQTRWAKPVETLEEIITTVSVSLPEFSELQDCFREELMEAVHLHLVKEYIIRLSKRRLVLKTAEQQQQLAKHILANADTIQHFCTENGSTATWLHAALPTISEIIRLQDPSAIKIEVATYATWYPDFSKGHLNAILAIKGNLPSSEVRSIRNILDINTGVQELSRPLFSLIKVA
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MQNPSHHEQQKSDHFSLQKVHEKHKAQPKKHEREIKKKQFYNPVEINEKDTQEFHWEKEVLGKHVTVINNEFTDEITKILDVNGIKELYPMQKIVQQFIFSTDTDIAVRAPTGSGKTLAYTLPLLKLINPLFNHIQVVILIPTLPLALQVSNVMKPLLKTINCNLVCLGESSIEKETSCNSHVIVTTPIRLLNHLSKSTLDLKWLQYLIYDETDKLLTIPALFPLLNIIKKQYISPQYMVDIKTGKSLNVFSSSTNQFRSLLFSATLSSSPKAFKQLQMNKPLLLTFDDSFVRDINEITQTKYVLPSTIENRYTPVLPIEKDLVVLELLKTSGKSIIFCNSNNTAFVLFRLIQEMAEFIGKDKKEIGCIISSMKQKEKLKVIKRVENDSINVFITTDLMSRGIDIKGLKTVINFDCPVSTQLYVHRAGRTGRAGNEGICHTIVLTNEVGNLKSYLKKMNNELHKVSVIVEESLIKSYNKITKLLEENPSTLQPEKQKKHI
The following text describes a protein:
Function:
Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MADVLSVLRQYNTQKKEIVVKGDEVIFGEFSWPKNVKTNYVIWGTGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPDRKDLLAYLNGETSTSSSIDRSAPLEIGLQRSTQVKRAADEILAEAKKPRIEDEECVRLDKERLAARLEGHKEGIVQTEQIRSLSEAMSVEKIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFAKNIFAILQSVKAREEGRAPEQRPAPNTAPTDPTLRNKQPIPAAYNRYDQERFKGKEETEGFKIDTMGTYHGMTLKSVTEGASARKTQTPAAQPVPRPVSQARPPPNQKKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRENETLIQRRKDQMQPGGTTVSVTVPYRVVDQPLKLMPQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTVLELSYHKRHLDRPVFLRFWETLDRYMVKHKSHLRF
The following text describes a protein:
Function:
Transcription factor (By similarity). Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes (By similarity). Involved in brain development (By similarity). May play a role in hematopoiesis. Essential factor in lymphopoiesis, required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of NR2F2.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles.
Domain:
The N-terminus is involved in protein dimerization and in transactivation of transcription; Zinc finger domains are necessary for sequence-specific binding to DNA.
Sequence:
MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHGPLGAPEGDHDLLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKGVDKPPSPSPIEMKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIADKLLHWRGLSSPRSAHGALIPTPGMSAEYAPQGICKDEPSSYTCTTCKQPFTSAWFLLQHAQNTHGLRIYLESEHGSPLTPRVGIPSGLGAECPSQPPLHGIHIADNNPFNLLRIPGSVSREASGLAEGRFPPTPPLFSPPPRHHLDPHRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELAGNTSSPPLSPGRPSPMQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPVKSKSCEFCGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEPGTSDLVGSASSALKSVVAKFKSENDPNLIPENGDEEEEEDDEEEEEEEEEEEEELTESERVDYGFGLSLEAARHHENSSRGAVVGVGDEGRALPDVMQGMVLSSMQHFSEAFHQVLGEKHKRSHLAEAEGHRDTCDEDSVAGESDRIDDGTVNGRGCSPGESASGGLSKKLLLGSPSSLSPFSKRIKLEKEFDLPPAAMPNTENVYSQWLAGYAASRQLKDPFLTFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQVGKDVYKCEICKMPFSVYSTLEKHMKKWHSDRVLNNDIKTE
The following text describes a protein:
Function:
May be involved in regulation of cell cycle.
Subcellular Localization:
Nucleus. Membrane; Lipid-anchor.
Sequence:
MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHNCIPELDNETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALQDAFLAIDAKLTTEEVIKELAQIAGRPTEDEDDKDKVADEDDVDNEEAALLHEEATMTIEELLTRYGQNCQKVPPHTKSGIGTGDEPGPQGLNGEAGPEDPSRETPSQENGPTAKGHTGFSSNSEHGTEAGQISEPGTATGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEVEEEEDDSEECSEDEDGYSSEEAENEEDEDDTEEAEEDDDEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPQEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICFKPRNTVELQAESGKRKLEEALSTEGAEDTGNSDKKKAKRD
The following text describes a protein:
Function:
Involved in salicylic acid-dependent inducible resistance responses. May release an endogenous peptide elicitor required for the activation of inducible resistance mechanisms. Possesses protease activity in vitro.
Miscellaneous:
MISCELLANEOUS: Gain-of-function mutant CDR1-D (T-DNA tagging) shows a dwarf phenotype with dark and curled leaves, constitutive expression of the pathogenesis-related genes PR1 and PR2, and resistance to virulent Pseudomonas syringae.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MASLFSSVLLSLCLLSSLFLSNANAKPKLGFTADLIHRDSPKSPFYNPMETSSQRLRNAIHRSVNRVFHFTEKDNTPQPQIDLTSNSGEYLMNVSIGTPPFPIMAIADTGSDLLWTQCAPCDDCYTQVDPLFDPKTSSTYKDVSCSSSQCTALENQASCSTNDNTCSYSLSYGDNSYTKGNIAVDTLTLGSSDTRPMQLKNIIIGCGHNNAGTFNKKGSGIVGLGGGPVSLIKQLGDSIDGKFSYCLVPLTSKKDQTSKINFGTNAIVSGSGVVSTPLIAKASQETFYYLTLKSISVGSKQIQYSGSDSESSEGNIIIDSGTTLTLLPTEFYSELEDAVASSIDAEKKQDPQSGLSLCYSATGDLKVPVITMHFDGADVKLDSSNAFVQVSEDLVCFAFRGSPSFSIYGNVAQMNFLVGYDTVSKTVSFKPTDCAKM
The following text describes a protein:
Function:
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production.
Subcellular Localization:
Nucleus.
Sequence:
MKGFLEDANYSIGLLDEGVNVAEVIDNCIYEHTINGKNGFFVGDLGKLIKHHIHWQNVMAPIKPFYNVKCNSTPGVLEILAALGTGFACSSKNEMALVQDLGISSENILFSNPCKQASQIKYAAKTGVNVLTCDNELELKKIARNHPNAKLLLHIATEDINGGEEMNMMFGTTLKNCRHLMECAKELNVQIIGVKFNVSNSCKEPQVYKHAISDARCVFDMAEEFGFTMNMLNIGSGFTDYEFDLEKINHVVSPLLDIYFPEESGVNVIAEAGCYYVSSAFTLAVNIIAKKAVQSTEPLLFKTEQTQGDDQVFMYYINDGVYGSFASKLSDNLTTIPEVHKKYKEDEPLFASSLWGPSCDELDQIVENCLLPELNVGDWLLFDNMGSGTLGEQSAFNDFQRPPVYYIMSISNWCEMQDAGFTCETLMKNFFFVPSCIQLSPEDGFSLAA
The following text describes a protein:
Function:
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
Subcellular Localization:
Cytoplasm.
Domain:
Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex; The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.
Sequence:
MYGSSNNNHILGQQSSQPPPPHNGLLFSNFQQDHLINGGGSPLSAYATNHLMGMGGNGVSGGGGSSTSPLYHNSYPQQQQQPQSQQQPQSQQQPQQPIYNPNNGLYGYPSQVGYDMVGVDQQDEYYDGTWFEMRVVPEYPASNIPNPITCLKFDPWEELLWIGYQNGKISSLINPTLDRFSSFFVDKTEIKDLLVDSEGILSLSKTLLSYHSRGGAPIYQVKNDKMKDLNAISFTNYNNTEIVVGSDQNILFVVDFYTGKVVKELTMPSGVKTINKNRGLWCGQVNGEISMLDPRTWKIEQSLSAHKGDIKSVDIKLDLLVSCGCSPRLGQLYIDPIVRVYDIKTLRSLPPIQYKRPSIVKFHPVFYSTIAVISESSNQIYLTDIQSDQSTSQYYQVDSLFGYMQSFDISQSGEIMALGDSGGLVHQWAEKEDIHVNVASYPTECVPFTQLSRPQKMDETSPLSEVVFDQQQPNAFINGSDPFLLSFWKPTLSFPVGLPPRPINPSLLAHLKQHDFVGYISNTGISRKQIRGKAYEDGKTKALNLTLSTMSQLRPPKVYRWGEMKFKKFGIEDFDMIQYNRTKFSGLENILPNSYSNSCIQNLYFIPQIKETMLNHLCTRYYCLSCELGFVFQMMDKSAGNIVDTSNFIRVLKQIPQTSALGIFLSSDHPDNAQIPLPQLIANFNRFILEQLQKEMTPPIPTYENNNNTNTNNNNNNNQNNNQNNQNNNENSLHNDTIIDTLFSSTLISCNKCINCGYQYEKISKQFQYDINYPSTPQELGPDGSTFSNILKQSLCKQIKSPAWCDKCQTYSSTYQKKNLKTLPNILCLNANCLKKENEDYWKFETTNIIPGSKTFKATGSTVPTSSSTSNTAPTSLTSTPSATSTAANITAPSSSSNSTTTTPTTSSTNVTIATITSSALNATVINPNDEITWLPLKIRIKIDENGQLLIIEYPNNPEKSKHTINPKDLTEEINEDGQLYELTSCISHIKDQVKRIPKQGHLITQIKVSDYYDKEFKPPYPTTPIYSSTASSIIHSINGKPSTPTTTSSSVSPSSTPPKYSLASNTTPNNTPTHNNALPTTPTPTPTTNNNNTIDLTWFNFNDFKINPCTPIDVTHFDSNWKTPAILYYTKVVPKEKRLSIPEHQPTITKEVYLQNNIITCKPPISFVPATPSTIPRENDYIAIDTEFVSIGPEETEVSSDGKRVIIQPGNFSLARVSIVRENGEPFIDDYIQSIEPVTDYLTRFSGINPGDLDPKISTKNVISLKSCYLKLRYLVDQKVKFVGHGLKKDFRIINIYVPPEQIVDTVELFQLRNQRKLSLRFLAYILLKIDIQTETHCSVEDAKTAMDLYKAYLILVKNKEFDETLNKIYQIGRGLGFRVPEPDADPSTLPPSSIMNSLNFNFDLNITISQLQQQIKQQYQQTTATTTSPLTPNKTPFTTPTKNFNDNQKNK
The following text describes a protein:
Function:
May be involved in disease resistance.
Sequence:
MARAILWVLLTVMAVSLLLHAGVEGVNFDIENQCPYTVWAAGTPFGGGIELKRGQSWRVNVPGGARGRFWGRTGCSFDGNGRGRCNTGDCGGLLNCQGSGGVPSTLLEYALNQYQNLDFYDISLVDGFNLRMTVVLSNTNCKRIACNSDINSKCPGELKVVDGCRSACAAFNTPAYCCTGSFLDNCPPTGYSQFFKRECPLAYSYAKDDPTSTFTCPGGSDYKIIFCGNGDSQSNSTSTSSGSLYAVE
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes. Also regulates the sphingolipid metabolism (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MICIECGRPVNDVYKEFGKAGSGNIRLTRCASCNQTADKYVEYDFIIVFLDLFLHKAQAYRHLLFNRQPYRDFGIPIQYIKVLVVYIFFESYIKWLRFKEYEQHPSGPAFYYIDWQDDVPYDRYWFIFVTAIAEFAVYILSIILSVRFIYESRYPIIKYNYLIMAIILSSFGKGFLVLMMIWDYPFSFGSILNIFVLSSNVVAIKVFLDTTTFKAIFFVVFGFLGKLLFQSIIYLFDASMLLHLSF
The following text describes a protein:
Function:
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network.
Sequence:
MATKARVMYDFAAEPGNNELTVNEGEIITITNPDVGGGWLEGRNSKGERGLVPTDYVEILPNDGKDPFSCGNSVADQAFLDSLSASTAQANSSAANSNNQVDILAQIGCIESLSQSPPSSPSPSPTINKVNHHVMMNHHVMNHYSTECKLWVSSSNDPWSAWNASTSGNWDSTDGWGAKPEGAAAQRNTSNNWDTAFGHPQAYQGPATGDDDEWDEDWDDPKSAAPYFKDSESAEAGGAQRGNSRAGSSSMKLPLNKFPGFAKPGMEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESELFQQFLNFRDEKEWKSGKRKAEKDELVGVMIFSTMEPEAPDLDLLEIEQKCEAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLPKEYQKIGKALQSLATVFSSSGYQGETDLNAAITEAGKTYEEIAGLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGAHKGAIEKVKESDKLVATSKITPQDKQNMVKRVGTMSYALQAEMNHFHSNRIYDYNSVIRLYLEQQVQFYETIAEKLRQALGRFPVM