lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSNAPEIVQRLIKMIMRAFYETRHIIFMDAILRHSALTDEQTALLMGIPIKECRFIAGKLREDRLLAIQSRTEMKEGQQRQYHTTYFYIDFCSTIDSIKWRMHQLVKTVEDRMRNDFDSKGYVCPFCNKKFSSLDVLSLVTNEGTFACNVCGTELKDDEESAEMMSSQKRLGKLMGQVNGIIDALKRVDEIVVPQNNFQSALEHAVPVSLDTQNLSQQNLSKSNSDVRLSTSSPSITVDFSADKETDEKRERNCDKQVKAAQNILPEWHATSTISGSITRAGAKDAALHSFRTETVNEVQDTKTDITSEKSALDAYYATLRAKQKEESEFMDSENVDDEEDDDFLDVTTATSLQNKSTDYGSVKRKTENLNSDSDIQNKRTKSIEENNSLPPIVSTNGITDGDTEMQESKKNVIINGFNEDDEDDEDEADFEDV
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
CKMLSAVRVSQPKKIYTFWSKFLGGSMWFWILWRLKHDWPDVVGHHHVLKDEAEGHH
The following text describes a protein:
Function:
Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V).
Sequence:
VGKLNRLSTLRGILKELKTTGSKNEATTFLLNKYKSNQITDGKHCREADALNHDASSYYCLLRSTREYKELCDRYHSGEGSTEGAAKRVGLKLPNLYKEGTKE
The following text describes a protein:
Function:
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the stag2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by espl1/separase at anaphase. May regulate kinetochore microtubule stability in mitosis, possibly to sense tension on mitotic chromosomes.
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Nucleus speckle. Note=Localizes to the centromere. At anaphase, it dissociates from centromeres when chromatids separate. Localizes to kinetochores.
Sequence:
MVKERCPKQAFQDSLEDIKERMKEKRIKKLAKVATVNKTLCTKVQILNSGSTAIKNYKANNTALALALEAEKLKTRQAQDLILGLKREHQRLIFEIFMLRRRLQSQQGRDTAESKLASLKDIIAKVTHNLLETASLLEPAHLLCSSANNNTPNPSKVEEKLSSGASAILRLPSHAPISDTLPKNVIPNRLEPEQRNFKDKVVLEANRNTAGVNRQSRGRRSHSNQPSFTSRLEECNNEDKTESGATMNKNVSLRRRASSLNICLEESLPLEDTNVNSEHTVVETERPFPTEEFSNESRTDREIDNVDNPASPLKVKCFPHANGSKMTGLASEAKQTSNKNKEEPRVGRERVKKGKAERVAVSQMKKPWENSKPRARSKSRDRSASKKSVAKEKMNSSLNSGDAFDFACEESIHVTPFRQNKQEESQNESSLEISSSEGELDDSLYKPYKDKSKNKNLKPDIAPVPLRSRSKRNTARKNSIAENELMSDVQAEANEKKITRNGLKRKSENSFTESAETYREKSFMPTCINTNNAIAENPEVKVFSDECNGGIIYTADEPSGASTPRISLSDVTNLPGNTDAKKHINLLFNEDEMKRSSTPSRKRRCKVSINYAEPKLSGKLRRGDPFTDSEFLQSPIFKNESKRNSLNRQSLSRYNEVFVGCRR
The following text describes a protein:
Function:
Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. Also required to enhance the solubility and secretion of VASH1 and VASH2. Plays a role in axon and excitatory synapse formation (By similarity).
Subcellular Localization:
Cytoplasm. Secreted. Cytoplasm, cytoskeleton. Note=Detected both intracellularly and extracellularly. Within cells, localizes mainly to the apical part of the cell.
Sequence:
MDPPARKEKPKVKEPVSRIEKAKQKSAQQELKQRQRAEIYALNRVMTELEQQQFDEFCKQMQPPGE
The following text describes a protein:
Function:
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
Sequence:
MSVADSSAADSVAAPDTADTSSSVGVFSPPGYYDALAQQVLDGTPITREQALAMLEASDLDVPAIISAGYRIRHQYFGNTVQLYFLMNAKSGLCPEDCHYCSQSKVSDAPVPKYNILKRDALMDAAKVAAERGAKTYCLVISARGPNEREMKAVEEIVPEIKQKYNLDICACLGLLDESQAARLKACGVDRVNHNLNSSESHYEKICTTHTYEDRVQTLRHVRDAGMEMCSGGIIGMGESKSDIVSMAFDLNELGVQSIPVNILNAIDGTPLEGTAALTPQDALKALAMFRFVNPDRELRIAGGRELHLRQLQPMGLYVANSVFVGDYLTTQGQAPQADYDMIRDLGFDVTGSCEEMSI
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MYTCLHLLVPLWQLPHPPAAPSARQILRACQLSSVTAAAQSCLCGKLVLRPLRPCHRYSTSGSSGLTTGNTAGAGLLFVGGGIGGTILYAKWASHFRESVEKTIPYSDKLFEVVLGSAPYNVPLPKKSTQSGPLKISRDTPASATTGDTVLVPGVQHEESLKTDHPEIDEGKPTPALSEEASSSSIRERPCEEIAACLAQQEKQEQVKTESLAKSLEDALRQTANVTLQAIAAQNTVVQAVNAHSNILKAAMDNSEIEGKKKSAKWHTVQDALKEHRKAVDEAADALLKAKEELDKMKTSYKLHSTIADLDNVVKKVQAAQFEAKVVSQYHELVGQARDDFKRQLDSITPEVLPGWKGMSVSDPADKLSTDDLNSLIARAHRHIDQLNRELAEQKATEKQHITLALEKQTLEEKRAFDSVVAKALEHHGSKIKIEEVRDAAAHTDHLVQEQELKYEFEQNLSEKLSEQELQFRHLSQEQVHNFTLDINTAYARLRGIEHAVQSHAVAEEEARKAYQLWLSVEALKYSMKTSSAEMPTVPLGSAVEAIKANCSDNEFTKALATAIPPESLTHGVYSEETLRARFYAVQKLARRVYFFSYLQSLLLFPPQQLKPPPERMAQDWLKEARITLETKQIVEILTAYASAVGTRTTQVQPE
The following text describes a protein:
Function:
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
Subcellular Localization:
Cytoplasm.
Sequence:
MKQTKEESVKLYLDFYDKYTWPLEIAETLLEVRQYLTESTILSLFQNFYFSHKGQRINEYSEFSIPDGGKLQVLLGTGFNNHIDEFNERTARFHLRRVQEIIANLSHYQYLCKGKISNEDSLSLKEIGDLQLNDILQPAIKPTLLLNDDNKAIKQNVQQLGLSSFNPPPLSRKLKGDLFYIVLKTIESVELIITASNLGFYVNSSQGRTFESTQKSDCYYNLIDLIVDHSPSFKKELINAIPEQQQPALPATIKYNHKWLSVPEVPLTLDHQRSESWALDLHGFDIGMKNCQVFRSLPKIDLIQKLNRDKALSKVYGDFVEAAVRGACAVVDKIIQPLNPMDVECQQVYVYNQIFFSFAMETPEDFRQESGPDATPTVSTTNCDFRNLQILHKLDIPGLSVLNTCLVDYKGRRVIAQSIIPGILNSDHSNCTQYGSIDDGKTIQKSEEFHKVMSKTCEFFHLDTDIVFLDSNQQKYSMAGSIEVKGIMGSDKRMYLLDLLRLSPRDYNYQGENNQCCVLRYELLQNYWVVNTIQKIKQNNSDDPKTQQEAYQNIQNLLIGNPKEGLKLNPALGTKTALQTSEKLTQQEEDLKKLATFLLNQAIPQLIQELSQPETSRHSDLSISDIFHSHGVNMRYLGKVISFIRSEEQPSLRLTLERVVFAKTLKHIFRESMRQAPQNQLSQILSHLLNVIFSNSNPSVNNNKQEEKKKKKKNKNKSTQNGDKPHFRCLIQANNYQYPTYQEVWDQINKIAEARYQHKIDSSILNKKGFHKLSCLRELCQQIGLQLVARDYHDFQPSDIVGIQPIIKFIEQVSEDAKNNIEIGQKYMLEHQNLHQALESYLTASQIILNLHGQMHKELANCYSKISAVYLRKQEYDAAIHFQKQAIQIYTAIYGYDHPLTIQAITALSLYYFSTKSYKEAFNHMLHTLYLANLIGGEGQEVFNQYTNLSLLYSESGQHQSALNCLFEGLEKCESLFKSFSGTETQQYKLRISGYYSAIALEHGEIGDFQKAVEFQERASDLLKRTLKPEDTRVKEADALLANLKKALNEKRKDTQQSNLDSRRQFGTNRNQQLKTEQQTQQISEETYVETDKEREALLQKLRAAKQSMKFKNKNQMDINRYILAQQLYRQQQQQQKE
The following text describes a protein:
Function:
Receptor kinase that detects X.oryzae pv. oryzae protein Ax21 to promote innate immunity. Following X.oryzae pv. oryzae protein Ax21 detection, undergoes cleavage, releasing the processed protein kinase Xa21 chain; The processed protein kinase Xa21 chain released by protein cleavage after X.oryzae pv. oryzae protein Ax21 detection translocates into the nucleus where it can bind and regulate WRKY62, a transcription factor. Confers resistance to the bacterial pathogen X.oryzae pv. oryzae (Xoo).
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MGWAVVLAILISSVLHPLLLTTLADESDNNRDALLCLKSRLSITTWNTTSPDFCSWRGVSCTRQPQLPVVVALDLEAQGLTGEIPPCMSNLTSLVRIHLPSNQLSGHLPPEIGRLTGLQYLNLSSNALSGEIPQSLSLCSSLEVVALRSNSIEGVIPLSLGTLRNLSSLDLSSNELSGEIPPLLGSSPALESVSLTNNFLNGEIPLFLANCTSLRYLSLQNNSLAGAIPAALFNSLTITEIHISMNNLSGSIPLFTNFPSKLDYLDLTGNSLTGTVPPSVGNLTRLTGLLIAQNQLQGNIPDLSKLSDLQFLDLSYNNLSGIVPPSIYNLPLLRFLGLANNNLRGTLPSDMGNTLSNINSLIMSNNHFEGEIPASLANASSMEFLYLGNNSLSGVVPSFGSMSNLQVVMLHSNQLEAGDWTFLSSLANCTELQKLNLGGNKLSGNLPAGSVATLPKRMNGLTLQSNYISGTIPLEIGNLSEISLLYLDNNLFTGPIPSTLGQLSNLFILDLSWNKFSGEIPPSMGNLNQLTEFYLQENELTGSIPTSLAGCKKLVALNLSSNGLNGSINGPMFSKLYQLSWLLDISHNQFRDSIPPEIGSLINLGSLNLSHNKLTGKIPSTLGACVRLESLNLGGNHLEGSIPQSLANLKGVKALDFSQNNLSGTIPKFLETFTSLQYLNMSFNNFEGPVPIGGVFDNTSGVSFQGNALLCSNAQVNDLPRCSTSASQRKRKFIVPLLAALSAVVALALILGLVFLVFHILRKKRERSSQSIDHTYTEFKRLTYNDVSKATNGFSPTNIVGSGQFGIVYKGQLDGKDSSVAVKVFKLNQYGALDSFIAECKALRNIRHRNLVSVITACSTYDLMGNEFKALVFQYMANGSLENRLHAKLQNNADLSLGTVICIAVDIASALEYLHNQCTPPVVHCDLKPSNILFDDDDTSYVCDFGLARLIHGYSSEAQSSSTSIAGPGGTIGYIAPEYGMGSQISTEGDVYSYGIILLEMLTGKRPTDETFGNGLTLQKYVDASLSEIERVLRPSLMPKIGDQPTITPKIEEYRATTVMHICALQLVKLGLLCSVESPKDRPSMHEIYSEVIAVKEAFFSMNS
The following text describes a protein:
Function:
May regulate STK11/LKB1 function by controlling its subcellular localization.
Subcellular Localization:
Cytoplasm.
Sequence:
MLRGRAPQLTVSLLGLFPKGDLVLSGCSTLTLLTTTLQQLNHVFELHLGPWGPGQAGFVALPSHPADSPTILQLQFLFDILQKTLSLKLVHIPGPGPQGPIKIFPFKSLKQLELRAVPLHCLCGLRGVYSQLETLICSKSLRALEELLSACGGDLCSALPWLALVCADFSYNSLTALDRSLHLLSALQILNLSHNQVRDCEDFLTALSELRHLDVSYNHLQSVPVMGPSGAVLRTLVLRGNELRSLCGLDQLRGLRHLDVAYNLLEQHRELMSLRMLPELHRLHLEGNPLSFHPNHRAATVQYLSPQIKEASPLGFFLDGEPLSRADLQPPTSSGLCSLALPLPPVGGSASETSYGPDLSDSPSSGAVLVRPLPRKSRSRVRVRQASISEPSDTDPEPRTPEPSPAGWFVQQQRELELMNSFRERFGCDWLQYRSHLETPGTPSLGTPKVSDFGELPLDPPNAQSLSSSLQLGEGASSVEESLLIGPEEGPSEEGVAVGMEAAVEEAKEEGPEEDGEVELCRPVLVRLLEGTGGACSPERFLRVTSGHLLEVELQAARVLERLDLRSLQAAELESEAEPQAQSGEVSADCDHAAKAPILVLRFSYICSDRQLRRYLVLEPDALAAVEELLAILAPTAAASRLQAGAAGGPLGGRLRCLRCHQLSTVMISKEELDSQGGWIPKTSTDSPILCPVCGSDHVVLWPQHDETPCGDGTEGGPGLASSQLPSTPPGSSDDVDGDNLSNSSPQAHVPDDANSWGLCPSSDRRGLRSVDHRIRLFLDVEVFEDVQEEFQCYLKVPVVFRGQSMEVPSLVVVSDLRLYVLEVTGEMRGQPSSWLQLCLAISLQDLSRLELGLAGQSLRLEWAGGGGGCILLPRESRCCRAFLEELGAILQSLPPGRRSQVSATKEEMIPQHRLWPLLGTDSGPEDPQFFYLRVFLIEGSSVCPMSLLITPSTLYLLNEDPVWSQAGPSPPEAGEEFLGASPSSLHPSVRIHEQQPLSSLNSIQVYRTALTDLRLALYDEVLRLESFWSLRVACPEQLTALLDWIRGPWEDLFSIELRVLTQEALDIEP
The following text describes a protein:
Function:
Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.
Sequence:
MLRCTNGAALRTSVQHTIRLRSLLVSRSAQVSQSILFGAPLARAAQRGRIVGQYVAWGSISGVKWYSTEASRLADAEEQSAADSTANFEDDEPHDKPQQKRNPAWDKRKRYQDHKLLAIAGGGARPDGDPLADVVRRKVVKKELQWLQDPKALADRVAKILQADDFALAVAIVRGAEKQNMECSVGWNHLLEYCMNKKQPKAAWKLYNEMKKRGRKPTSWTYTIMLYGLATVPKNVHMGLNPVKTALSIYRSIYELNSAVKPSIIHSNAMLTVCVRHGYTDTLWEIASELPEEGPCSPDAVTYTLILRAIRDAVYTDVSKMSEVDRILERKAQSVKEGKRIWSDVVYRWSRGQLDIDTQLVRAMARLLLEGGSDRDCYDVFALLNQTTGLPILAKKPSPERQRESEVARRRKSRSAENKEMEDVPFVDEGNRPYKPAETEMEEREEKTEQTEEEEDDEEFENLFDPVVSTGSSSKTKKGNIGPSYVVLGDQELTILIETCYTMTQGVGTGKAYWKYLTLEDHEYTIKPGMPSLHAYLRLLRVYRASRATVDVVRDQVPEPGWKTFHIAMSCCLRDRRNINILKNANELLGIMDKSMVLPHPRALDKYLNLVQTLQDNPQRLISLNGLKIARKPSDSLDVVGRKLRLSLQTVALENLRPHIDKLHEALKNGKTSFISHVERRQAGAADTVCGATARTVMDRTRGLIDELLKPENAPFLSKSDREQLEQESQKLRVYSDVEMVRKFESTRLHPTFEQVMAFQEKHDPKQNTDEAD
The following text describes a protein:
Function:
Specifically binds poly(G) RNA homopolymers in vitro.
Subcellular Localization:
Nucleus.
Sequence:
MWGDSRPANRTGPFRGSQEERFAPGWNRDYPPPPLKSHAQERHSGNFPGRDSLPFDFQGHSGPPFANVEEHSFSYGARDGPHGDYRGGEGPGHDFRGGDFSSSDFQSRDSSQLDFRGRDIHSGDFRDREGPPMDYRGGDGTSMDYRGREAPHMNYRDRDAHAVDFRGRDAPPSDFRGRGTYDLDFRGRDGSHADFRGRDLSDLDFRAREQSRSDFRNRDVSDLDFRDKDGTQVDFRGRGSGTTDLDFRDRDTPHSDFRGRHRSRTDQDFRGREMGSCMEFKDREMPPVDPNILDYIQPSTQDREHSGMNVNRREESTHDHTIERPAFGIQKGEFEHSETREGETQGVAFEHESPADFQNSQSPVQDQDKSQLSGREEQSSDAGLFKEEGGLDFLGRQDTDYRSMEYRDVDHRLPGSQMFGYGQSKSFPEGKTARDAQRDLQDQDYRTGPSEEKPSRLIRLSGVPEDATKEEILNAFRTPDGMPVKNLQLKEYNTGYDYGYVCVEFSLLEDAIGCMEANQGTLMIQDKEVTLEYVSSLDFWYCKRCKANIGGHRSSCSFCKNPREVTEAKQELITYPQPQKTSIPAPLEKQPNQPLRPADKEPEPRKREEGQESRLGHQKREAERYLPPSRREGPTFRRDRERESWSGETRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVRLTTANVRIIKNRTGPMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIDGKMVAVNLATGKRRNDSGDHSDHMHYYQGKKYFRDRRGGGRNSDWSSDTNRQGQQSSSDCYIYDSATGYYYDPLAGTYYDPNTQQEVYVPQDPGLPEEEEIKEKKPTSQGKSSSKKEMSKRDGKEKKDRGVTRFQENASEGKAPAEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDYEEEEEEEQTPPPQPRTAQPQKREEQTKKENEEDKLTDWNKLACLLCRRQFPNKEVLIKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREGKFKGRGNDRREKLQSFDSPERKRIKYSRETDSDRKLVDKEDIDTSSKGGCVQQATGWRKGTGLGYGHPGLASSEEAEGRMRGPSVGASGRTSKRQSNETYRDAVRRVMFARYKELD
The following text describes a protein:
Function:
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (By similarity). Regulates p53/TP53 by enhancing the DNA binding and transactivation function of p53/TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42 (By similarity).
Subcellular Localization:
Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear.
Domain:
The ankyrin repeats and the SH3 domain are required for a specific interactions with p53/TP53.
Sequence:
MMPMFLTVYLSNSEQHFTEVPVTPETICRDVVDLCKEPGENDCHLAEVWCGSERPVADNERMFDVLQRFGSQRNEVRFFLRHERPPNRDIVSGPRSQDPSVKRNGVKVPGEHRRKENGVNSPRLDLTLAELQEMASRQQQQIEAQQQMLATKEQRLKFLKQQDQRQQQQAAEQEKLKRLREIAESQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNSLFQQKQRELVLAVSKVEELTRQLEMLKNGRIDGHHDNQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVSELRDRLWKKKAALQQKENLPVSPDGNLPQQAVSAPSRVAAVGPYIQSSTMPRMPSRPELLVKPALPDGSLLMQSAEGPMKIQTLPNMRSGAASQSKGSKAHPASPDWNPSNADLLPSQGSSVPQSAGTALDQVDDGEIAVREKEKKVRPFSMFDTVDQCAAPPSFGTLRKNQSSEDILRDAQAVNKNVAKVPPPVPTKPKQIHLPYFGQTAQSPSDMKPDGNAQQLPIAATSVGAKLKPAGPQARMLLSPGAPSGGQDQVLSPASKQESPPAAAVRPFTPQPSKDTFPPAFRKPQTVAASSIYSMYTQQQAPGKNFQQAVQSALTKTQPRGPHFSSVYGKPVIAAAQNPQQHPENIYSCSQGKPGSPEPETETVSSVHESHENERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAMETISVPSHPSKSPGSVTVNPESSVEIPNPYLHVEPEKEVGSLVPEPLSPEDMGSASTENSDVPAPSAGLEYVSEGVTDSSTNLQNNVEETNPEAPHLLEVYLEEYPPYPPPPYPSGEPEVSEEDSARMRPPEITGQVSLPPGKRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGVIYALWDYEPQHDDELLMKEGDCMTVIRREDEEEIEWWWARLNDKEGYVPRNLLGLYPRIKPRQRSLA
The following text describes a protein:
Function:
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
Subcellular Localization:
Endomembrane system.
Sequence:
MDLASLIFSNRVNTCADISLQLQSNSLFFFPSFHKSNIIWSSLFVILFFFKTKLNKTLTSSTHLFIIISYNTIDIRKMSDGKLFTRSKTTELRTELEQAFKKSKPVVRVKVVLKKVLANIILNNHEVTNLMKDIIPLMKIDDLEVRKLCCEYISTYATTNPDAEDAIPFFSRFHSDPNPLLRVLSLKTMVSINRKEFLNLSITSCKRSFSDKDPDVRKSAAYAAGQIYQHDPARAEREGLIELLNQSLYDENSSVISSALASLGTVIENSKTLNLKIDKNHALTLIKLLRATNEWQQTYILNALMSYTPQNEDEALNLIEAVLPSLQHENSSVVMNAIKVVIYYCNYARNPELRLPVLPKRLGTSLVSLLSKPAETQFLVLRNVILLLLGRKEFVHFDVEMFYCRFDDPIYVKDTKLEIIYLLANESNVGSVLRELEEYATEVDVSMARKAIRAFGNLAVKLENAAEQCVEVICDLVSNGISYIVQESAIVIKNILRKYPGQFEFAISELIKHYKLIDEPDAKTAFVWILGQYCQNIKESKSILEDFITSFKDDPLDVQYATLTAVAKYYLKFPEQGESVILRVLKWATEEVDNPDIRDRGYIYWRLLSSEHASGPNGEFQLNTKKIILNDNPVITSENDNINPVILEELELNIGTLASIYLKPVQTVFRLSKHKELPYSPALQRRNSFHSGVATPQPQSRNSKEHSPGAGAGVSRRMSYRRTNSDNGSQRSTHFDETTNTQQHMPRENLAQKFSRKASFITNRIKS
The following text describes a protein:
Function:
Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
Sequence:
MTSRRDWQLQQLGITQWSLRRPGALQGEIAIAIPAHVRLVMVANDLPALTDPLVSDVLRALTVSPDQVLQLTPEKIAMLPQGSHCNSWRLGTDEPLSLEGAQVASPALTDLRANPTARAALWQQICTYEHDFFPRND
The following text describes a protein:
Function:
PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Membrane. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Cleavage furrow. Midbody. Cell junction. Note=Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow and concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells.
Domain:
The N-terminal regioninterferes with the interaction between AKT1 and the C-terminal regionof PKN2; The C1 domain does not bind the diacylglycerol (DAG); The apoptotic C-terminal cleavage product inhibits EGF-induced kinase activity of AKT1 phosphorylation at 'Thr-308' and 'Ser-473' sites, PDPK1 autophosphorylation and kinases PRKCD and PRKCZ phosphorylations.
Sequence:
MASNPDRGEILLTELQGDSRTLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKEGAENLRKVTTDKKNLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDSTDCPRTPDTPNSDSRSSTSNNRLMALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFKIEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNELPRNHPKSSVVIEELSLVASPTLSPRQSMLSTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSDNRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQTPVPATVPVVDARIPDLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGETDESSELRVLDIPGQGSETVFNIENDRNNLRPKSKSEYELSIPDSGRSCWGVGELDDKRAQQRFQFSLQDFRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAGEKDAEDVKKHPFFRLTDWSALMDKKVKPPFVPTIRGREDVSNFDDEFTSEAPILTPPREPRILLEEEQEMFHDFDYVADWC
The following text describes a protein:
Function:
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MDVLNAVYNLNNEETLKSSWFGEVFSSFSTQETYQWGFQLLPVLLAAIFATIISVTYFCIRKCHRKALFARQLKSEEASARFRKRDKALFYGRKMLRKVKNISGQVRNSGQGRKRKMVMKFARRILQLKKENDTEQLKVLEPPVEYLQEEMLSDDRMPPDALYMLQSIRVFGHFEKPIFLKLCKHTEVINVDAGQHLFKIGDADENVYIVQSGKLNVFIASADNTNLSLKIVKPGESVTSLLSFTDVLTGNTNPYKTVSAKAIEDSTVVKLPMVAFQEIFHEYPDIFIRVIQVIMVRLQRVTFTALHQYLGLSAELVKQGPKSRNSKNPLVGGSPMKKKREDFRDGSFSSMDASQPIPVPGHRRSKSSLESKSFSPQTPDMVSDAEMATSGMTPDVALLQRKRHSVDNVDEDTLIEIATEAFIKELNLEDDTMLKGNVQIKEIAAGTYLMQEDSNKDVALCYVISGALIVSQKMTESEDEVHMFTSYHGEFVGGLAVLTGEPSFFTIRAKHFTRIALLSKNTFYSMMKDHPNIVLYVAHSVVQRLSPFVRQVDFALDWLFMESGRAVYRQDDESDSTYIVLSGRLRSVITHKNGKKELVGEYGKGDLIGVVEMVTHTKRSTTVIAVRDSELAKLPEGLFNAIKLKYPIVVTRLINLLGHRILGSWKKPTISVHAPSSSAIDSRPSQLNFSTVAIVAASDDVPLTAFTYELYHCLCAIGPTLRLTSDIIRKILGPTIMDPNNEYRLTSWLAQQEDQHKISLYQCDLTVSAWTQRCIRQADCILIVGLGENHPSIGKVEKEVERLAMRTQKELVLLHREGGKPHNTVAWINMRSWVAWHHHILSPNRMFSRKSLYRINELYSKVCQSEPNIHSDFSRLARWLTGKSVGLVLGGGGARGSAHVGMIKAIQEAGIPIDMVGGVSIGAFMGALWCRERNITTTTQKAREWSKKMTQWWRQILDLTYPMTSMFSGRDFNQTIKGTFGDTYIEDLWLPYFTVTTDITASCMRLHSHGSLWRYVRASMSLSGYMPPLCDPVDGHLLLDGGYTNNLPGKKPKNTNSVVCMPSVTGKYTGSVRLHTQNQGHLWRYVRASMSIVGIFPPLCDPLDGHLLADGCYVNNVPADVMRSLGANHIIAIDVGSVDDQDLTNYGDDLSGWWLLWKRWNPFTDPVKVPNLPDIQSRLAYVSCVRQLEEVKNSDYCEYVRPPIDKYKTLQFGSFDEIREVGYQHGKAYFEEKSKSGNLPIFKAPTVTNKPETEHILSDYTFTDLAQMVCKVSRPYEESSSSSSSGDEFEDGQDGYASEPTVCLMDNKIDKLLHMRRAGGSLSLSENEIESEVEFDVTNRKSEKELKFSSL
The following text describes a protein:
Function:
May be involved in the transport of dicarboxylate compounds.
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Sequence:
MESLALRSISLSASYLSLHRSSSKSFALLPPSISVHTSPTLRSLSISSPRFTLRATASSLPEEQNKPQPPPPSPPQPQGAKLIPLAISVSIGLIVRFLIPRPEQVTSQGWQLLSIFLFTISGLVLGPLPVGAWAFIGLTASIVTKTLPFSTAFAAFTNELIWLIAISFFFARGFIKTGLGDRIATYFVKWLGKSTLGLSYGLAFCETLMGLIMPSTMARAGGVFLPVIKSLAISAGSYPGDPSSRKLGSFLIQTQLQCSGASGAILLTSAAQNLLCLKLAREVGVVISNPWITWFKVASVPAFVSLLCTPLIIYKLYPPELKHTPEAPAAAAKKLERLGPITKNEWIMLGAMAFTVSLWVFGEAIGIASVVSAMIGLSTLLLLGVINWDDCLSDKSAWDSLTWFAVLIGMAGQLTNLGVVAWMSDCVAKLLQSLSLTWPASFIILQACYLLIHYLFASQTGHAGALYPPFLAMQIAAGVPGVLAALCLAFNNNLSGALAHYSGGPAALYYGAGYVDLRDMFRVGFVMALVQAIIWGGVGSFWWKFLGLY
The following text describes a protein:
Function:
Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA.
Subcellular Localization:
Spore coat.
Sequence:
MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQPMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENILRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDYITFDEEIAYTYPYSMASYSPR
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Sequence:
MLLSRKYKNINNNNNNNNNNNNNYNKNNKTKIKYTLEDILVDFNSLEDKYMCEICAECLFKDLNKIEAFQCKEGHVFCTSCWTQSLARKKECMACRAPCDFKTLSKNILLQKDFREKKVCCPNIYRNAGGKIVKDEKFGCKMIFSFDELESHLKNCPYEFIECPFNKSNTPKESKCYCIIRKNSIKKHQEVCSITIGVCTYCQVDFGKKEILKQHQDTTCPKYLVKCTQECKNGKPGNNNFVMVERGNLQNHIKNDCPKTQIQCKYIDGGCTEIFQRCDQVKHLNDVNHSVYIQNIRDQQFKASQEMVAKLTIENQELQKKLDQYSIKINQLELKYNNTNSLLTQNKKDFEEFTYSQTFANNRFYNYINEKESKTILKENKYKNRWEHSFNPLYEKFVSPEIIFGYNKFLITITKTQISISLALGLFSSSRNVMFTIKLNDDIVLQCKCTRFTHTDSTRRANLPVGFPYQYLNNGKLTFEISIEIIDEPPLQPLKSV
The following text describes a protein:
Function:
Part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEISSRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAALLWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVYTAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFLVSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT