lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
UDP-glucosyltransferase catalyzing in planta synthesis of cyanogenic glucosides. Able to glucosylate acetone cyanohydrin and 2-hydroxy-2-methylbutyronitrile, forming linamarin and lotaustralin. Also accepts, to some extent, a wide range of potential acceptor substrates, including simple alcohols, flavonoids, isoflavonoids and other hydroxynitriles such as p-hydroxymandelonitrile, mandelonitrile, (E)-4-hydroxy-2-methylbut-2-enenitrile and (E)- 2-(hydroxymethyl)but-2-enenitrile.
Sequence:
MGSSAIARDERSHAVCVPYPAQGHVNSMLKLAKILHSNGFHITFVNTEYNHRRLLRSRGPDSLDGLPDFHFEAIPDGLPPSDADATQDIPSLCDSTSKHCLLPFRHLLSRLNSSNTVPPVTCVISDGCMSFTLDAAQEFGIPNLLFWTHSPCGVLGYAHLPHLIERGFTPLKDESYLTNGYLETTIDWIPGMKNIRLRDLPNRIRTTDRNDTMLNFIVREVERTSRASAIILNTFEAFEKNVLDALSTMFPSIYTIGPLQLLVDQFPDSNLKSVGSNLWKDQPECIDWLDSKELNSVVYVNFGSITVVTPQQMVEFAWGLANSKKPFLWIIRPDLVVGEAAMLPPEFVSETKDRGMLASWCPQEQILKHPAIGGFLSHMGWNSTLDSVCGGVPMVCWPFFADQQTNCWFACNEWGIGMEIDNDVKREEVEKLVRELMDGKKGKEMERQAVEWKIKAEEATTPGGSSHRNFVELLGFLQRK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSSCFVPNGASLEDCHSNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLSVWRRDQRPGRRELWIFWWGDDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEISQHQPVYLLSEEHLTLAQQSNSPFQADAGYALEDKGAMGPESVILSPFGLNGTLTGQSFKLSDSSTKKLIGEWKQFYPVTSNLKEGSEEKQEDMDWEDDSLAAVEVLVAGVRMVYPACFVLVPQTDIPAPSTVGTSHCSTTCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDAQSAQKWVKFSSVSDGFISDSTSHHGGKIPRKLANQVVDRVWQECNMNRTQNKRKYSATSNGLCDEETADKVASWDFVEATQRTNCNCSRHKNLKPRNSGQQGQAPPVGQQQQAAPKHKTNEKQDKGDKPQKRPLTPFHHRVSISDDVAMEADSASQRLVMTAPDSQVRFSNIRTNDVAKTPQMHNAEMHNAEMANSPQPPPLSPHPCDVVDEGVNKAPSTPQSQHFYQMPTPDPLVPTKTMEDRLDGLSQPFPAQFPEVIEPTMYIGTAVNLEEDEADTTWKYYKVPKKKDVEFLPPQLPNDKLRDDPVIPAGQENITSVTELMVQCRKPLKVSDELVQQYQSKNQYLAAVVSEADQEPEIDPYAFVEGDVEFLFPDSKKDRQNIERETGKKHKAEDGTSGVTVLSHEGEDAMSLFSPSVKQDAQRIAAHARTASTSLIHETDLVVSYTDLDNLFNSDEDELTPGSKRTVNGADDKSNCKEAKAGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTLGGTVLEGNSSSMGAQFRIEVDEGFCSPKPAEIKDYSYVYKPENCQALVGCSMFAPLKTLPSQCLPPIKLPEECIYRQSWTVGKLDLLPPGPAMPFIKDGDGSTMDQEYGPAYTPQTHTPFGMPPGSAPPSNGGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNSSGLFLEDELDILGRNTECGKEAEKRFEALRATSVEHGSAGLKEPEKLPDELILLLQDQCTNLFSPFGAADQDPIPKVGAVSNLVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKTTCLHHWSKRNVVDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDVAYVVVCPENEALLNGAKSFFRDLTAIYESCRLGQHRPICKLLPDGIMRVGPTASKKLSEKLVTEWFSQTANANNEAFSKLKLYAQVCRYELGPYLASQPLDNSLLAQTNLVPPSSQPASALPPLTASTGNPNTPSAPAASTSSTMTATSNSAMSSAATTANSTLTTTATSSSSANIGSGIPTNKPSSFPPFSSMNNTTSASLPSQAATVQNGQTGGQQQQPVLQTAGMSGDATTAPAQPHPEVSESTMDRDKVGVPTDGDSHAITYPPAIVVYIIDPFTYEKKDENSSSSSLWTLGLLRCFLEMVQVLPPNIKNIISVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPSSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWLLASCTDLYGEQLETCIINIDVPNRARRKKGSARRLGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFIIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASSTYTTENLDLAFNTNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDMGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQLYNFIMNML
The following text describes a protein:
Function:
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.typhimurium. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Endomembrane system; Lipid-anchor. Cytoplasm, cytoskeleton. Note=LC3-II binds to the autophagic membranes.
Sequence:
MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLVPQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYASQETFGCLESAAPRDGSSLEDRPCNPL
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MRKRQIDTLKIFNHNVQEVKENEEYLVNFDCGGREIAINILLGSGFPNEKPKLIVSPILRHPWVNGTTGEIENAPGILNYTIHSDLGRVVQAVGREFEKHPPRFVNESTPQHHAPPPAAAAGAAANQHHQQCRNGNVPDYSVDNRNALLSPSHEPDPFGLRNLTTDELSRLNADEDYLEEFVAKLPFLQHQNDELDQLLAGIESLAVDNLARKQTVEERKAKLESLALEFKELGQQWESMNQRYQRKAEDFSPQHIKELLQIAVSTADSKSDDEAQRFLAGQSDVGTFLQNFIESRKLYTMRKAKEERLVQQLTALERAAF
The following text describes a protein:
Function:
Tissue-specific calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which specifically regulates MCU channel activity in the central nervous system and skeletal muscle. Senses calcium level via its EF-hand domains: compared to MICU1 and MICU2, MICU3 has a higher affinity for calcium. MICU1 and MICU3 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake. At higher calcium levels, calcium-binding to MICU1 and MICU3 induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU3 heterodimer away from the pore, allowing calcium permeation through the MCU channel. The high calcium affinity of MICU3 lowers the calcium threshold necessary for calcium permeation through the MCU channel. The MICU1-MICU3 heterodimer promotes flexibility of neurotransmission in neuronal cells by enhancing mitochondrial calcium uptake in presynapses. It is also required to increase mitochondrial calcium uptake in skeletal muscle cells, thereby increasing ATP production (By similarity).
Subcellular Localization:
Mitochondrion intermembrane space. Mitochondrion inner membrane. Note=Recruited to the mitochondrial inner membrane via its association with the uniplex complex.
Domain:
EF-hand domains 1 and 3 have high affinity for calcium and act as sensors of mitochondrial matrix calcium levels (By similarity). EF-hand domain 2 is degenerate (By similarity).
Sequence:
MAALRRLLWPPPRLSPTLAPQQPFLSPWGRPAGTAPGMSGRPFSGREEDEGAVAEAAWRRRRWGELSIAAAAGGGLVGLVCYQLYGDPRADPSELVAPELDESPRGRGLLPIPVAAAKETVATGRAVTEDLDLYATSRERRFRLFASIECEGQLFMTPYDFILAVTTDEPKFAKTWKSLSKQELSQMLSETPPVWKGSSKLFRNLKERGVISYTEYLFLLCILTKPHAGFRIAFNMFDTDGNEMVDKKEFLVLQEIFRKKNEKRETKGDEEKRAMLRLQLYGYHSPTNSVLKPDAEELVSRSYWDTLRRSTSQALFSDLAERADDITSLVADTTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVLEIEFLSYSNGMNTISEEDFAHILLRYTNVENTSVFLENVRYSIPEEKGITFDEFRSFFQFLNNLEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKLSPHLVNTVFKIFDVDKDDQLSYKEFIGIMKDRLHRGFRGYKTVQKYPTFKSCLKKELHSR
The following text describes a protein:
Function:
Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
Subcellular Localization:
Secreted.
Sequence:
MTSVWWLLLLATTLSQMVHTQEQPLLEEDSAPADNLDVLEKAKGILIRSILEGFQEGQQNKRAFPDEMEMISKRQHPGKRFQEELEKRQHPGKRDLGDLNLELSKRQHPGRRFLEEIEKRQHPGKREEGEWSRGYRSDDSSYLDLLSDVSKRQHPGKRIPDPLFTKRQHPGKREAEEEDDTEFEISKEVAKRQHPGKRFDPCEGPNAYNCNSGNFLPSSLEEGWAT
The following text describes a protein:
Function:
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MYTFSGDETAPFFGFLDVAVVLVFSCMGATYGTAKSGVGVASMGVMRSKLVMKLIIPVVMARVLGIYGLIIAIIISTDGAHRIPHIFLGDYLLRGGNGCRSINFVGGNEGSKSFTGTSKINSSGGLSNYNSMLTSNFDGKGTWLIFNLGDTIYINDFNSQDKDPIKAIHFSNSNPVCHAFDAKAKDGHDLLIGLNSINVYSDSLRHQLQDFGKKLVGAQHYNKYGSVSTNYCTSIALIPQGYGVFVVAHSVGNLSMYEKAKDGTGSLLLHIHGTVRSLELLAAASRKILSKEAHPRAYERKIRGDFGKGAS
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Sequence:
MIPIYMKKLLPIFIHTFQSSMWLPVRKASLTLIKKIIGYIEASLLEEIVKPDSTSSNSNISVQLSEILSTVLNAEEEEESHYVVLQIIQELLKKYPSAFMDQFVQLGIFNRIQNMAGGEGNEDEKIASHAFSDHNSHVEMVMFRPYTWKSWCLVRGRDCIYLWSEYAALELSNGSNGWFRYILENKLSTMYSSGSPEGGTDSSENRGEFLEKLQKVRNQVKASIPVQSIFATTDASALVVGNWTFVCKNDNELHIQNSDGQQTTILKEDQTGFIFESNRGTKHPFISAISLGPEFASGWAGHKSKKFFSKTEEIKQKVKTLAYDIYQVHFKTAQSIPRGTMSHLHNIINKLESAWNQQIKNMPWEDELRSSYEEILALFNDEHAMSAYEFYTSGLIQSLLNTLNLYVDSNDMKLLTKKRVDLFKQVFKDKKVGNQCASALLVRKLIAVLESIEKLPIYLFDLPGTTFSLQILSKRLKFKFERAAEELNLVDRTGRSLKMEPLATVGALEKYLLKMVAKQWYDYDRSSHTFVRRLQEATFKEITFCHQRDFDENGLIYWIGTNARTTKDWINPASCGLMVVSSSEGRTLPYGKLEDILSRDTAAINCHTNDDRKAWFAIDLGIWLIPTCYTLRHARGYGRSALRNWLFQVSKDGITWLTMFNHVEDTSLNEAGSTASWPLEPSKEEKEGWRHVRILQNGKNASSQTHYLSLSGFEIYGTVTGVCLDLDKTVRESEAQQRRQRRYIRMHVLKNIVPGVKVVRGLDWKWKDQDGSPPGEGVIIGELHTGWVDVAWDAGGLNSYRMGAEGKYDLTLAPAHGTEETSTALKLSSCVVPTTQINNRLASEAVASAFLLSSSLQQVSNHGTLKPSIMRKLFSQDLLLENNRFASASSSASNRLLHRANNNPLGCYVLGGASNDSYLLNMLQQNDTLQHQLGSLQQVKSKMGYVIACFFKYIFCVNSFATNNPNFNQVELAVGFPQPSLPSTSCSTPSTVAQSMSVSVPNLNTSLDQTVSFLESFSTIARCNLTNNLSNLLDSNNETINSADQKVHATQSTSFTLLSTAQSFPNLTSGSSSLTTHTLTSAAESSRIARRNNNSHVTALSQALTMSLASSDSDNDFLEMCRATTLLAELEDDDELPEVDDECADNENEDNDQQHHKTEEAMDLDDTTANESENTTNNKASNNLDISKKKTWDDEFELKRQFSSLIPAFDPRPGRTNVNQTQDFDIPPPGQDLNLSDPGTAITSSSMLAGSNADEIEIALEDREASIFKYVQNLVIQSSAPSSNNKQDRLKRIWEPTYIISYKESKCNPYPNQHAHVDGWPIWQVAQQLGTALLPKRILINYMQERAPQHFLEKWKLIGADKNVKKCHNCSQLTRAYKVSSTHKTALPSSSITAAEPSTSLFKLTTTAKPSATDLIDGHSSCSVNDVLSLLKLLHHIFLENSTANAINGNYLEKDLPTVSEDDFLSKKITNKLIQQVQDTLMLSTNAIPDWCEELTTNYPMLFSFETRLMFFNCTAFGTSRSIVWLQNKREAMLERNRTAGGLRRDDVHDFKIGRLKHERVCVPRDESLLDWSMQVMKYHASRKSILEIEFKGEEGTGLGPSLEFYALVAAELQKKDMGMWLCDDELDGEQAHDDSGKEIDIGRGVKPPGYYVRRSSGLFPAPLPQNSDDMARIESLFKFFGTFVAKCIQDNRLVDMPLSLPFLKMLCNKRDNAVELASPILLDDDLTPTENDSFAATPSTIASSLQQSTVGSCVQLLPWYVGILNNDDFLLLDSIRASFLNDLRKLSEKKQQLMNEGISHDKSSTDCKLFLENGARLEDLELTFVFNPSSKVYGYSTYELKKGGETEHVTLEKVDEYVELVTDFCLVSGIRRQMEAFKAGFDLVFPMHKLSVLNPLELQTILCGDQCPKWSLEDILNFTEPKLGYTKDSPGFQRFVNVMLKMNADQRKSFLQFATGCSSLPPGGLANLQPRLTIVRKVDSDDNAFPSVNTCVHYLKLPEYSSEDILMERLLTAIKEKGFYLN
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the formation of dihydropteroate, the immediate precursor of folic acid and the reduction of dihydropteroate to tetrahydropteroate.
Miscellaneous:
MISCELLANEOUS: FolP can complement an E.coli strain in which the two distinct genes encoding dihydrofolate reductases folA and folM are deleted.
Domain:
The N-terminal extension of FolP is essential for the reducing activity and binds FMN.
Sequence:
MIVKRLNPDALKNALQKIGPEKIAQDRMHQKGVSFVFEIQHLPLSATLILKQEAISVGGDFATPRDCILAKEPFYDGVLIASAKQLERLIVKCHSQPFGLKHLAQELKSHLKAPKPNTPQIMAVLNLTPDSFYEKSRFDSKKALEEIYQWLEKGITLIDIGAASSRPESEIIDPKIEQDRLKEILLEIKSQKLYQCAKFSIDTYHATTAQMALEHYFSILNDVSGFNSAEMLEVAKDYKPTCILMHTQKTPKDMQENVFYHNLFDEMDRFFKEKLEVLEKYVLQDIILDIGFGFAKLKEHNLALIKHLSHFLKFKKPLLVGASRKNTIGLITGREVQDRLAGTLSLHLMALQNGASVLRVHDIDEHIDLIKVFKSLEETD
The following text describes a protein:
Function:
Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis.
Subcellular Localization:
Basal cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MVVVVGSGSGVCNPVLGNWNWNETQSLGLQMSSLCLMNAAVAWLPSVYLWVISPFYFLYLRYNNKGYIRMSCLFKTKMVLGFTLVLLCFSNIIFTLWKIKKGIPQAPEFLINPTVWLITMILAIFLIHLERRRGIQSSGVLFIYWLLCSFSMAVTVSATVHQALQGGFPEDTFRHLITYFHSALIGAQFVLSFLADQPPFFSKIMHDSNPCPESGASFPSKVTFWWFSRLVWQGYRKPLEMDDLWSLGKENSSEEIISRLESEWKRICNETQQTKEEMGFERGGGNRAEPALPPETETFLQGHQSPRFPLLKAIWKVFNGTFLLGTLSLIVCDVFRFAVPKILSFFLEFISDPEAPAWKGYFYAVLLFLSACLQTLFEQRHMYVCMVLEIRLRTAVMGLVYRKVLALSNAMRKTAAVGEIINLVSVDVQRLMDAVLYLNGLWLPVIWIIICFTFLWQLLGPSALTAIAVFLILLPLNFIITKKRSCFQEEQMQHKDRRARLTDSILRNMKIIKFHGWEEAFMEKILTIRKGELQALKNSGFLFAVSLVSFHLSTFLVALVMFAVHALTDEKHVLDAEKAFVALTIINILNRAQAFLPFSINTIFQAWVSLARLAAFLHLEEVEPRAISTTPVGEESISVQDGTFAWSQENSPCLQRINLVVPRGSFFAVTGPVGSGKSSLLSAILGELTKLEGNVNIKGSVAYVPQEAWIQNASVEENVCFGQELNMPWLDRVLEACALPPDLASFPAGIHTEIGEQGINLSGGQKQRLSLARAVYKKAAIYLLDDPLAALDAHVGQHIFDRVIGPGGLLHGTTRILVTHAVHILPQADYIIMMADGAVVESGSYQELLQRNGPFTDFLGQSKQEEANASQEVKSSRNISESEASTNKTDSFIKDSPEKGRTTLQSRAEGTKMAGQLTEGDRVHYGRVNATLYLAYLRAVGMPICLSVVFLFLCQQMISSSRGYWLSLWADDPVVNGTQQHTGLRVGVFGLLGCLQAIGRFGSIAVVLLGGVQASQWLFQGLLREVSRSPMTFFEQTPIGNLLNRFSKETDAVDAVIPDKFKSFLGFLFGLLEVIVVVVVATPLAAVMVLPLMALYVGLQSLYVASSCQLRRLESASRSPIYSHISETFQGNAVIRAFQAQDQFIAQNDSRIDEHQRASFPRLVADRWLATNMELLGNVLIFAAAFFAVLSKPYLRPGIVGFSVSVALQVTEILHWAVRSWTDLENNIVSVERMRDYTRTPKEAPWTLSSNGVSHTWPVMGQIEFRGYSLRYRPELALALQNLTLKILPQEKVGIVGRTWAGKSSLSIGLLRLIEATEGGSDRWGEYQSKWAPCPEVQITIIPQDPILFPGSVRMNLDLLDEHSDDEIWGALEMVQLKTFILGLPGQLQYECLDQGDNLR
The following text describes a protein:
Function:
Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
Sequence:
MPRLFTGLEIPAEIGQTLSNLRGGLPGARWIDPENYHVTLRFIGDIDGVSANEIASMLFRVNRKPFEVKVQGLTSFGGRKPRAVVATIAPSKPLIELQAELERMMQRIGLNPEGRKFIPHVTLARLHDATDRDVADYLSLRGYFPSKAFMAERFVLFSSRASTGGGPYVVEDAYELCE
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRNLRNIGHGAYRPGQEQPLPSNSISASCWDVSRDEIILAHGPTQDFSRVELVRLVKDSSEPSNLECKLVASWDAAPVLRQNGSEPEPDTIKSLHYFPDTLTTCVIMAGGDIITVVEDDYGVPGEAHVEIVGTLEPSVAGARWSPDEELLIVATGDAKVLFMSRTFDVITSATMTEDDLKLSKHVSVGWGKKETQFQGRGAKAKALRDPTIPEKVDEGRLSANDDLHKCSISWRGDGAYVAVNFFSQESGGRRVIRVYNRDGELDSVSEPVDGLEGSLSWRPEGNLMAGIQRFSDHVDVVFFERNGLRHGQFTLQIPQDRPEVAEDLALEWNSDSNVLAVIMRDRVQLYTMGNYHWYLKQELPCAGYAQLASQFQGESRWTLPWFSWHAEKPLLFAVAAAERAVWFEFVLAIARGPMYGGMGDVAVIDGRTIKFTPFQTANVPPPMALYDIEVDYPVTDIAFSKDASQMAVLHQKGMHLFALEKQGPAGRRAAPKLIKTISLDNFENKCQLQIAFTAPSQVQVLSLDDFQLQITAWDFNEELMLGEVGTGLQAVTLTSADETSVEDGTVVQDRQGNITRISVENGETVLGKFPTLLPWATYTTYEDQFIAFGLSRNGHLYANSRQLVKNCTSFVVTDEHLIYTTSNHFVKFIHLTANVEELDVPLDDPETDERCRSIERGGRLVTAMPSRMSIVLQMPRGNLETIYPRAMVLAGIRQLVEQKEYGAAFTTCRTQRVDMNLLYDHRPEQFLENVGLFLDQVKNAADIDLFLSTLKEEDVTQTMYRNTKTGVVATPIQPALITAPKTSKINTICDAVLHSLKAKKNANLQNIITAHVCKNPPALSDGLQVVASLMEEDESLAERAVEHICFLVDINKLYDHALSLYNLELTLLVAQQSQRDPREYLPFIQSLHKMDPLRRQFTIDDHLSFHEKALVHLRAIANTYSDEVESYIVKHQLYPSALALYRNEPTPLRTITALYAAHLRSLSKFRDAGLAYESLGDYPAATECYLKAGTSSWRECLFTSSLDPSLTPDQRHEIASTLADALREAKDWAAVATIQAEHLASLPSAISALCKGYLFADAFRLISLHSRPELLESHLDPGLLDAFSSSTEFLADCKSQLKAQVPRIAELRLKAAEDPLAFYEGENPFGARTGGDIPDDISVAASSRVSTSASLFTRYTGKGSQVTGTVASNVSRATSKNRKREEKKRARGRKGTVYEEEYLVNSVRRLVERVEGSARLEVERLVCALVRRGMSERARAVEGLMAEVVEGCLRAVEEVWPQQQQQQQQQEGGGEQDASGWEGAEWRPTGGDAVLADSIEAMRRGVGKPVVKKFERLSLLGGR
The following text describes a protein:
Function:
Catalyzes the final step in the biosynthesis of the membrane lipid glucosylceramide (GluCer), the transfer of glucose to ceramide. Glucosylceramides play important roles in growth, differentiation and pathogenicity.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The D1, D2, D3, (Q/R)XXRW motif is a critical part of the GCS active site, involved in catalysis and UDP-sugar binding.
Sequence:
MVQEELSLFRITTGYFFLLWYIIILVAAYSGFFEILFNFRNRPILHTKQQANHQNDPESDDEEIYEGVTIIRPIKGIDPELTSCLESSFCQNYPRSKLQILFCVDDPNDPSIPIIQKLIAKYPTVDAQILTSESYNSQTKTSDDHYGPNPKVNNLAKGFVHAKYDILWVMDSNVWASSNILKNSVISLNGNLNMSRKMGQSRPVKLVHHVPLALSINNTTRSDDFIGGQDLEITAMTPVPSSESLNSQLVKRKSSPKSNNSLNVHPGFTYSKFSKKLGAELDEMFLHTSHSKFYVSLNNLAVAPCVNGKSNIYRRSDLDQSVRLIPHKDSPFFKDPKVKQDAGYYTSLGVGHAIKFFARYIGEDNMIGIALWENTQGRTGLTGDVVVQPYSGSENNAVKDYIQRRVRWLRVRKYMVLLATLIEPTTESIICGIYGTYAISTVFFGTWFNKYWFVMHMLIWMLTDYVQYHTLINHTLDVKNITYLPNWLNESIPPKQRNCLQWGYIWILRELLALPIWIIAMIGHEIDWRGRPFRIKKDLTAEEM
The following text describes a protein:
Function:
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Subcellular Localization:
Cytoplasm.
Sequence:
MIDLNTVPSLPGVYLFKDSKGKVLYVGKAKNLRNRLKSYFQSDDLDPRKSKMVKLIKDFSYIVTSNEFEALVLEANLIKQHKPSFNVLLRDDKSYPYLRITVVEEWPKIDVVRKPKKDGNLYFGPYVPAQSMWEALSFIRRNFPIRTCKYRLNKPIRPCVQYQMKRCPAPCAGFISREDYMKGVNEVVLFLKGQKTELLNILYEKMQKLSHELKFEAAAKIRDQIRRLEKIFTQQRVVSQTLDDMDVIGVYIENSKISVNTLFVRNGLLVGSNDWTVKKAFYESEGELIHAVIEALYSKEALIPPPIIVLENLPESLTEIKEWLKEKRGDFVELKTPSLEEEKALLDMALNNAKIHLQSKISPLETSLKELKQRLNLSEIPSKIGAFDVSTLFGSYSVGSFVYWQDGFFDKNLYRHLRIKEIQGIDDYSAMKEIVHRVVKKFNAELPEPDLILIDGGLGHLNAAIKVINELKEKLNVFAIAKDPDRLIFPDGRELVLEDKKPSSLLLKKIRNEAHRFAISYHKKLRKKATFESLLEKIQGIGKKRRLTLLKHFGSISKIKAATVEEIASLQGFNLRLAGKVIEELNKIS
The following text describes a protein:
Function:
May act as an intracellular pH sensor that links chemotactic signals to responses in the microfilament system of the cells by nucleating actin polymerization or stabilizing the filaments.
Subcellular Localization:
Cytoplasm. Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MGNRAFKSHHGHFLSAEDCKVKTHHGHHDHHTHFHVENHGHHKVAIRTHANKYVSINDNNDVYISHHFHGEHSLFHLEHHGGKVSIKGHNHYYIAADQHGSIYTTHHHHHDATFEEFIV
The following text describes a protein:
Function:
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
Subcellular Localization:
Cytoplasm, nucleoid.
Sequence:
MAGNKKINRREEILQALAEMLESNEGASRITTAKLAKQVGVSEAALYRHFPSKARMFEGLIEFIEESLMSRINRIFDEEKDTLNRIRLVMQLLLAFAERNPGLTRILSGHALMFENERLRDRINQLFERIETSLRQILRERKLREGKSFPVDENILAAQLLGQVEGSLNRFVRSDFKYLPTANFDEYWALLSAQIK
The following text describes a protein:
Function:
Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Can also catalyze phosphatidyl group transfer to water to form phosphatidate.
Miscellaneous:
MISCELLANEOUS: All three cardiolipin synthases (ClsA, ClsB and ClsC) contribute to CL synthesis in stationary phase. Only ClsA contributes to synthesis during logarithmic growth phase.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MKCSWREGNKIQLLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQRGVKAEVLLDGYGSPDLSDEFVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVIDARIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDILQFELENLPGQSAARRWWRRHHKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQARREVIIANAYFFPGYRFLHALRKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHWATVGSSNLDPLSLSLNLEANVIIHDRHFNQTLRDNLNGIIAADCQQVDETMLPKRTWWNLTKSVLAFHFLRHFPALVGWLPAHTPRLAQVDPPAQPTMETQDRVETENTGVKP
The following text describes a protein:
Function:
Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
Subcellular Localization:
Cytoplasm. Secreted.
Sequence:
MVRHGELPTAESSGPGETLQQDVLQTSSGWESPEGSPKALPLPQDSDSALAPSGDTTAALCLRVRSLEAELETCRQELREIQRRLSQSEWLHRSTETHNQELQRQVKELNREIHESKRAEQTDQEVQTDDYYAWAQSDSYYYSSNGNDSSGFAVEVSEQVSVTEDSHSSQVVAEARLYEAGASSAPCVGEDQEETVYAQQAEEEQGCSLAESLRATAEAALTQTGFVYDESTGMYFDHSTGFYYDSESQLYYDSATGIYYYCDVDSGRYLFHSRVDLQSFTDTNPRTTRDKRSKKKRRDPASMEKDTEKIEGDSVIPEREDLAAEKKKARMNSSIESYERERSSSEESDPEEGEITDSDNEKASSDDNMSSGLSITSHTSEPEDLERIWPPCIRVTVVRSPVLQTGTLFIITADKTASIGREKDLGHTIRIPELGISKFHAEVYFDHNLQSYVLVDQGSQNGTVINGNHILQPKEVSQPCVLQHGDEVKFGETVLSFHVHPGSETCNGCEPGQVRAHLRLNKKEEHSAGPILTKEGKELLRKQGLKKIRAKYGLQSADYEDNKVLTNPKYKDRADRRRQVVGSEGTFHKQEAPASVHVEINDRNKGRKMLEKMGWKKGDGLGKTSDGIRDPIQLQLRKKKAGLGSQNPTSIEDIQSTTQNQKNWEKARERFAEAFPDAKTKNETKSNVTWIKATTE
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MVPLLLILGQGLVYLLYALIFSEMVLIMTLLFDAPMTKTAILELDSLKLNQGKGLLIVKIVTGTLFLVLMANFYSVLRITMKNRTNEGGGLNPTEEVLKSMNILQISLIGIVLFLVLMIDSLHHYIRGLPSLVMAMEAAKTQNQSFRKEKTESVQKLNTMVQEKDTLRTKLKYLESECKSEANEANKARAEAEALRQESEEFLKEYDRLLADNQNFRNQSKLVEQRFTKQSISHPNDKKNL
The following text describes a protein:
Function:
Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis.
Subcellular Localization:
Nucleus.
Sequence:
MGWKRKSSSPEPQPNLVKLPKRESLSRSPSSWKRKASTPSKTKSWTSIQSLSPDRHVDQCNGQEKMSSAGHVEDDSDCIQSSTPVSSPLRSEEDAELGLVITVDEDRCEGEEWLKKRNGVNIKKNGINQTEGEIPQKEDGDVEKTMEQLSEEDENEEELRKLDRDLTLKSKKLNLSSINVRNIIHEVVTNEHVVAMMKAAIKETQDMPMFEPKMTRSKLKEAVEKGVGMGNWNISPIKKANDIKPPQFVDIPLQEEEDSSDEEYCPDEDEEDETAEETFLESDVESTSSSPRGIRRFPSQTPPHCDDASNSPRLKPRLARHLRVEAVPMGPPAPPPQSCGLSRSLKTLDPFIEKLHAVDKELELSPLCMEPYQALSSGGAGEPDDSLVACRTRSKRPLRDVPLDQLEAELRAPDITPDMYDNVSTPEDREWTQWLQGLMTSHLDNDEEADEDDDPEYNFLDDLDEPDLEDYRNDRAVRITKKEVNELMEELFETFHDELAANEPDDEGHDEDEEREEEANDTPQFNVPQAIRFEEPLAHMLTACRRTVREQLDALQQRRENQVRTTQHASGPGMVFVQPSCPLVVTPAQRIQLQQQIQQHVQLLTQVSMLCDPVGALQTEAQTTKHFLGELLSFAERAEEERSAVNLGFKSVFRVCNLLSSINLLEEVKQSPSLSCLPPKPNRHHSVHSYPLLPAGLAWLFATRSVFLYPELLPHCSLDPALHPSRSKHYYSKGEDGLLVLGLKHFAQTEFPYQLISRYLIRPKRQEQLRMRVKDMVSPKYPHNIIKYYCQNHVVPPLPVVCKPVVHGEERPPVEREQEVMPNWLKKSLPLIQKSICQSDLTMTSTTKSASLPFPKETRYPQFLPKGLSLRLHPSQVASRPSQPKSRILRAFTNRTLAPLAKAPSCPTGTGHLLTNISTPVLLLAQAPSTPINGVFPLVHPSLTPAHGTVPLNASYPINFHYLSPELGASNPAHLPANLPPSVVQKPQCDVPLLSTGTVKTHGVQQQTSDKHKKRTMPRKLAPLRPAPQLPRLLPLSSGSIGNISNPGIIIDQQISLNVPHNLQSDNVIVIKAHENVNTHRTVPSLSPDLVVQLVPQTQVAENTTSSLPRKTTPRSDVSQTAKDIPSVQSSGENGQRTVFSPQTAAPAAVDSSQFVLVQTVSPTGPPQFLLLPQDSLVLNQPASLPSEGTLQNLSQQTSHLDISTTSTALKNSEKTEVHLNNPTTSLPVSREEDGERQEVDEEMVGDRWEEEMASALFGSPLLALSESSCSPDSSPDASMDSGSDAMVRVEMEDGELPSVHSASATQETPDVHKHSSGDEKEQQSSGGEKQNSGNEEGRAEESESRKDEAQDEDKGGEKNEDGEGDGKRDEGGSGDKGREEKDGDGEKDGDGERDEEEEDFDDLTQDEDEEEVMSSASEESVLSVPELQETMEKLTWLASERRLCREGDSEEDNSPTSPTSPTSPNSQNSPASQNSQEENSEDEDDGAMKGDELEAGEGEGEKLPEGDAPAGDDPPQISEKVGGRGRGRGRPPPRSLKRGRRQERGSKDASKLLLLYDDHILDNDPMRESKDMAYAQAYLNRVREALQDVPGKVEEFLGLLYEFDQAGESHSVIELFAQLKQLLKDWPELLKDFAAFLLPEQALECGLFEEQQAFERSRRFLRQLEISFGENPSHYQKIVRALQSGSPLSPAGIEELKTQMATLLKGHTHLQGEFWMFFDEMRPPPARPGQFEEAVWPEDVATGTDGEAGVSVTSRGGVWGGFEEVTLPDLDEDEESHKIRQISSRSKRRKELHTYKDCDWPEKDCSCSCHDSVHDAKHRRHKRKGCLRCQSNKAANGSKVLKGRDSAFSSADAQSERGGEEKEEERVLGEDGEAEKELKDETGSGANSPHHDGEGSVWEREERATSSIPEEQNTHNQDDEEKTEEKNHHASPEKHSRDEEDSAESGQTEAAQQSSLSPALDAPVCAKNISLTPTGERVILWTREADRVILTTCQQQGASQSTFQAVSEQLGNKTASEVSRRFRDLMRLFHTSASQASSEDEAAEQQSATDEEQD