lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The SOCS domain mediates the interaction with ELOB and ELOC, while the NHR domain may be involved in ubiquitination substrate binding.
Sequence:
MAAASEPVDSGALWGLERPEPPPTRFHRVHGANIRVDPSGTRATRVESFAHGVCFSREPLAPGQVFLVEIEEKELGWCGHLRLGLTALDPASLAPVPEFSLPDLVNLGHTWVFAITRHHNRVPREGRPEAEAAAPSRPPTLLVEPYLRIEQFRIPRDRLVGRSRPGLYSHLLDQLYELNVLPPTARRSRLGVLFCPRPDGTADMHIIINGEDMGPSARGLPAAQPLYAVVDVFASTKSVRLVQLEYGLPSLQTLCRLVIQRSMVHRLAIDGLHLPKELKDFCKYE
The following text describes a protein:
Function:
Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity). Required for proper neural crest cell migration into the frontonasal primordia during development.
Subcellular Localization:
Nucleus.
Domain:
The OAR motif may negatively regulate DNA-binding and therefore transcriptional activity. It is found in the C-terminal transactivation domain that stimulates transcription.
Sequence:
MEYLSDKFSLKSPAIKGSDYYMDQVMDTLDNVQYYNKASPKCVQAFPMQSNDQHSSMDRSSPCDNQSSVTYCAPKSEESSLHAMENCCSLRVSPATSGPDKTDLDELGEKCDSNVSSSKKRRHRTTFTSAQLEELEKVFQKTHYPDVYVREQLAMRTELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISMLPRTDSYSQISNNLWTGPSAGSSVVSSCMIPRGSPPCVTSPYPHSPRAAEHGYVGFPNHQQNQFGVNHVSLNNFFADSLLASSANSHAAFETKPEFERRSSSIAVLRMKAKEHTANISWAM
The following text describes a protein:
Function:
Required for normal Golgi function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MATAATSPALKRLDLRDPAALFETHGAEEIRGLERQVRAEIEHKKEELRQMVGERYRDLIEAADTIGQMRRCAVGLVDAVKATDQYCARLRQAGSAAPRPPRAQQPQQPSQEKFYSMAAQIKLLLEIPEKIWSSMEASQCLHATQLYLLCCHLHSLLQLDSSSSRYSPVLSRFPILIRQVAAASHFRSTILHESKMLLKCQGVSDQAVAEALCSIMLLEESSPRQALTDFLLARKATIQKLLNQPHHGAGIKAQICSLVELLATTLKQAHALFYTLPEGLLPDPALPCGLLFSTLETITGQHPAGKGTGVLQEEMKLCSWFKHLPASIVEFQPTLRTLAHPISQEYLKDTLQKWIHMCNEDIKNGITNLLMYVKSMKGLAGIRDAMWELLTNESTNHSWDVLCRRLLEKPLLFWEDMMQQLFLDRLQTLTKEGFDSISSSSKELLVSALQELESSTSNSPSNKHIHFEYNMSLFLWSESPNDLPSDAAWVSVANRGQFASSGLSMKAQAISPCVQNFCSALDSKLKVKLDDLLAYLPSDDSSLPKDVSPTQAKSSAFDRYADAGTVQEMLRTQSVACIKHIVDCIRAELQSIEEGVQGQQDALNSAKLHSVLFMARLCQSLGELCPHLKQCILGKSESSEKPAREFRALRKQGKVKTQEIIPTQAKWQEVKEVLLQQSVMGYQVWSSAVVKVLIHGFTQSLLLDDAGSVLATATSWDELEIQEEAESGSSVTSKIRLPAQPSWYVQSFLFSLCQEINRVGGHALPKVTLQEMLKSCMVQVVAAYEKLSEEKQIKKEGAFPVTQNRALQLLYDLRYLNIVLTAKGDEVKSGRSKPDSRIEKVTDHLEALIDPFDLDVFTPHLNSNLHRLVQRTSVLFGLVTGTENQLAPRSSTFNSQEPHNILPLASSQIRFGLLPLSMTSTRKAKSTRNIETKAQVVPPARSTAGDPTVPGSLFRQLVSEEDNTSAPSLFKLGWLSSMTK
The following text describes a protein:
Function:
Probable histone methyltransferase (By similarity). Required for embryonic development.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Sequence:
MNYEKIDSTIPGPGISETDWNDVFEGCNCEAECSSAAGCSCLINKIDNYTVDGKINKSSELLIECSDQCACILLPTSCRNRVVQCGPQKKLEIFSTCEMAKGFGVRAGEQIAAGEFVCEYAGECIGEQEVERRCREFRGDDNYTLTLKEFFGGKPVKTFVDPRLRGNIGRFLNHSCEPNCEIILARLGRMIPAAGIFAKRDIVRGEELCYDYGHSAIEGENRKLCLCKSEKCRKYLPMSATPIE
The following text describes a protein:
Function:
Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation; Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.
Subcellular Localization:
Endoplasmic reticulum. Endoplasmic reticulum lumen. Secreted.
Sequence:
MRLPLPLLLLFGCRAILGSAGDRVSLSASAPTLDDEEKYSAHMPAHLRCDACRAVAFQMGQRLAKAEAKSHTPDASGLQELSESTYTDVLDQTCSQNWQSYGVHEVNQMKRLTGPGLSKGPEPRISVMISGGPWPNRLSKTCFHYLGEFGEDQIYEAYRQGQANLEALLCGGTHGPCSQEILAQREEL
The following text describes a protein:
Function:
Forms cell-cycle specific filaments between the spindle pole bodies of dividing yeast cells.
Miscellaneous:
MISCELLANEOUS: Strong overexpression results in the accumulation of filamentous structures resembling the neurofibrillary tangles found in cells of patients with Alzheimer disease; MISCELLANEOUS: Overexpression is lethal in haploids and causes very poor growth in diploids.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Nuclear during early bud formation, located at the spindle poles during late mitosis, very low abundance in resting cells.
Domain:
The coiled coil domain is essential for dimerization.
Sequence:
MSNKSNRRSLRDIGNTIGRNNIPSDKDNVFVRLSMSPLRTTSQKEFLKPPMRISPNKTDGMKHSIQVTPRRIMSPECLKGYVSKETQSLDRPQFKNSNKNVKIQNSDHITNIIFPTSPTKLTFSNENKIGGDGSLTRIRARFKNGLMSPERIQQQQQQHILPSDAKSNTDLCSNTELKDAPFENDLPRAKLKGKNLLVELKKEEEDVGNGIESLTKSNTKLNSMLANEGKIHKASFQKSVKFKLPDNIVTEETVELKEIKDLLLQMLRRQREIESRLSNIELQLTEIPKHK
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. Regulates trichome branch positioning and expansion.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLTRYQIRNEYGLADPELYGAADRDDPEALLEGVAMAGLVGVLRQLGDLAEFAAEIFHDLHEEVMATATRGHGLVVRVQQLEADFPSIEKAFLSQTNHSSFFSNSGVDWHPNLRSEQNMITRGDLPRFVMDTYEECRGPPRLFLLDKFDVAGDGACLKRYTDPSFFKVEPASSIATVEMQREKKIRKVKKKGSRWRNGETPEAALTSHAKLHELFLEERIENGHSDPARLVKLKKRHLNGSAVDSKTGKSYMEKFLETPSPERKLVCETSVTPPLLRLTSDNTGEPELRILDISIVSPAAMSPETKSTSSSPNSQEAILELSVDGFNGEAYDEEVAKGSEPNSDVETNKSYSNLQKVAVDKRLAGDGEHKTGGSVEGSTPSSSDDMTSEVDNYMDALATMDSEMETDNEYKPKNNVRFLNVEKYGTDSDANEEEHLDLPTRFPDSQSIGNSSASDDGKNSFEKDRASISHSDTLSNLVQSTPSECNGAAKEFPSTETCGADNFEMSSDQNSEIAESLEATLKEHVVSQNACIKEEVLPDSGDTSCSAFVRETSPTLQHSDPGANSQVVSLAGLVLDETPSDEINVGYKSLDINENGTHLDDSLAVVPNDSSQNKDEFTNTSSSHPVDESDDEDLGVSSDALLHLSDVEELSSEDQIGNNAVNEMSQTQCANEDSIESFARRKSDSPFLSISPTEEQVSSSALPEVQTPSVNSEVIPFVVDAAWSTEELCPVVDAPQTHGLLEQQDAPQTHGIIEQQDAQQTHVLIEQQDAPQTHVLIEQQDAPQTHVLIEQQDAPQTHGLIEQQDAQQTHVLIEQQDAPQTHVLIEQQDAPQTHGLLEQQISDLSEDVPQLESISAEAVAPHYKQKIDVEETSRTMDGEELRLVTSGADVEGGDTVSVELPSNCLTYPGHEDHAKSDDVVPETLHVETVAVPYTAVAQPDDHVNDVSHSSPNAISSPPRNFINLHESLPGFGDSQEKESELDEVVFPEFVTYSEVQKEASKKEVVSLDSESNSSKSVAYDLSSSTNGGHLDELTENSLAVCDVTAESNPSKSTTYDHSSSKISDNGHNFSPDQQSENSLAVHDVTTASTSLEMSHPESESQSLDQSDKEDVVSSPTCHLPEPETSSEKSLELQANQVDMEYLPRDGADRPEAALEQSLVFQSDQLDVECLQEDRASTNSSSLQSAQIGAPNHMDEERSKELPSTENVNQDIGLDASSESCPRDLPSQPLTSVVLPESAGQEVDVTKQIMEPLESTLPRLVPEATAVNLEDMPPLPPLPPMQWRIGKQHPSLPSFLPIQPSEADEKAQFDIPAPQREVLQPQNPFLPLTYVEDGKSQHVSEPLMGNVVHPAPYSLHLPAIVNDANYQYSFPDLGGAQFPNPFLSSSEISDDRSGHNHFALEGEKVQSSTNPFMVPHTECTTFRHEPESSDGAIILPLQQLTLETDLESKVLEHSLKNSEWEHGKPPPTSVTAPTMVDEQPQHSLTTSEGETTWSPNNSAAMSDYEVGRSNGIPVSKLPRPRNPLIDAVTAHGQSKLRKVTERIRPQVEPKVDERDSLLQQIRTKSFNLKPASVTRQTVTRPSIQGPTTNLRVAAILEKANAIRQALTGSDEDDEDSWSDS
The following text describes a protein:
Function:
Growth-regulating oxygenase that catalyzes the hydroxylation of ribosomal protein uL16 on 'Arg-81'.
Sequence:
MEYQLTLNWPDFLERHWQKRPVVLKRGFNNFIDPISPDELAGLAMESEVDSRLVSHQDGKWQVSHGPFESYDHLGETNWSLLVQAVNHWHEPTAALMRPFRELPDWRIDDLMISFSVPGGGVGPHLDQYDVFIIQGTGRRRWRVGEKLQMKQHCPHPDLLQVDPFEAIIDEELEPGDILYIPPGFPHEGYALENAMNYSVGFRAPNTRELISGFADYVLQRELGGNYYSDPDVPPRAHPADVLPQEMDKLREMMLELINQPEHFKQWFGEFISQSRHELDIAPPEPPYQPDEIYDALKQGEVLVRLGGLRVLRIGDDVYANGEKIDSPHRPALDALASNIALTAENFGDALEDPSFLAMLAALVNSGYWFFEG
The following text describes a protein:
Function:
Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force. Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus. Functions at acidic pH via alternate outward- and inward-open conformation states (By similarity). Protonation of residues in the outward open state primes the protein for transport (By similarity). Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (By similarity). Also able to transport antifolate drugs, such as methotrexate and pemetrexed. Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes (By similarity). Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (By similarity). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (By similarity). Hence, participates in the trafficking of heme and increases intracellular iron content (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cytoplasm. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells (By similarity). Localizes to the basolateral membrane of choroid plexus (By similarity).
Sequence:
MEGRVSPVGSSHRLLTAAVLFRGPVEPLVFLANFALVLQGPLTTQYIWHRISTELGYNGTRHRENCGNQSADPVLKEVETLTSHWTLYMNVGGFLVGLFWSTLLGAWSDRVGRRPLLVLASLGLLLQAVVSIFVVQLQLHIGFFVLGRALCALLGDFNGLLAASFASVADVSSNHSRTFRMALLEACIGVAGTLASLLGGHWLRAQGYANPFWLALAVLIVMTLYAAFCFGETVKEPKSTRLFTLRHHRSIVQLYVVPAPEKSRMHLALYSLAIFVVVTVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLGLRLLQFCLADTWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVTTPVIRAKLSKLVSESEQGALFSAVACVNSLAMLMASGIFNSLYPATLNFMKGFPFLLGAGLLFIPAILIGVLEKVNPHPEFQQFPQNS
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
Miscellaneous:
MISCELLANEOUS: In contrast to the orthologous protein in animals and plants, this protein does not contain a HMG box DNA-binding domain. This function may instead be provided by the HMG box of the associated NHP6 protein in the FACT complex of fungi.
Subcellular Localization:
Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
Sequence:
MSSTTQWENIYHGLDTTPGKLRMSQGGLGWKPSVGEGSTITIPADQMASFQWIRVARNYQLAIYLNKDRDAPSSAQTNPRRTNFDGFVRDDFDRLSSHIRQYFNKPLEAKEVSTRGWNWGQAKISNHDVQFLVRDKLAFELPLSHLANSNIAKTEVSMEFLNPEQQQPGANTGTSDVNGTKSRRSKGDQLVEMRLYVPGQAIKDDGSDAASAQDDDVNNEETAAEAFHEALKSKADIGQVAGDSIVVFKEVLVLTPRGRYDIDVFSTFIRLRGKTYDYKILYSSMNKLFLLPKADEIHVMLVIGLDPPIRQGQTRYPYLVLQFPREEEMDAELNLDEQTIQEKYDGKLKKRYEEPTFRIVTNIFKVLSGQKVATPTDFESSSGQTSIKCNVKAADGNLYPLEKSLLWVSKQPVYVPYSEIHQAILSRVGGAVASSKTFDLRVATKSGTEHTFQSISREELDRLKAWLADRKVRIKNEMAEETGGLAAAAAAGLLSDDDDEEMGAAGGADEDEDSEEDADFAADSDSDGGSPSEASSDEGEGGGYDDEGDERPKKKRKD
The following text describes a protein:
Function:
May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen. Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGSQVRLVIAVCGIYATFLTWSLAQEPLTTSVWPNSAARFSHSSFIVLCQALTAAVVGLCYLKAQRSGYGAREFIRKHWADVAGISLTQALSAPAANHSLQYVDYVGYMLAKSCKLLPIMLVHVLVYRTPIGRDKALVGVLVSGGVALFTLGGAERKQGEASLYGLGMLLVSLFLDGLTNASQDRLLRRPASKKITGAHLMVALNTAIVLWNLAYLVLFDRTQWQGSLQQLHADPAILTYLFTYCACGALGQCFVFFTLEHYSSLVLATVTVTRKMVSMLLSIVVYGHSVRPVQWLGILVVFGGIIWETVKKGQRGSGQKSKQH
The following text describes a protein:
Function:
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
Sequence:
MGWSGSPLTLPPLRGSPPLPQVERDRTQPQLLAFADAFPSEGRGELRSRERRGEATGRGGLRMTAPTRPLGHLYLVATPRPGQSEAEFLRRVEDALAGGVDTLQLRCKADSGQYGEARPYIALAERLRDLAHARNVPFFVNDRVDVALAAGADGVHLGQNDLPVEWARLMAPGLRVGRSTHRPEDAARALAEAPAYFATGPVHATPTKPGRVAAGLGYVRHIAALRPTLPWYAIGGIDLGNVQAVLDAGATRIAVVRAVLDADDCAAAAHALREALMVNG
The following text describes a protein:
Function:
Contributes to various developmental events through its interactions with multiple signaling pathways. Dorsalizing factor which functions as an inhibitor of bone morphogenetic proteins (BMP) during gastrulation. Promotes dll1-dependent activation of Notch signaling and is required for neural crest formation. Induces endoderm and dorsal mesoderm formation by enhancing nodal2/Xnr2 activity while inhibiting ventrolateral mesoderm formation through inhibition of fgf8.
Miscellaneous:
MISCELLANEOUS: This factor is named 'Tsukushi' because its expression pattern in chick embryos is similar to the shape of the Japanese horsetail plant, tsukushi.
Subcellular Localization:
Secreted.
Sequence:
MALSSWIFFLLVHGIVGGSRTCFPGCRCIVDNFGLFHSFSLTKVDCSRVGPHVVPVSIPLDTSYLDLSSNRLKRINESVLSGPGYTTLMNLNLSYNQIVKISYSTFSKLRYLESLDLSHNLLETLPDGSFLYSRLTELDLSSNKIQKVGVGAFTLKSQGRSMTINLANNEIHSIFRGAERPVPNIHSLMLYGNQLLSVPDLHGIPLRHLNLDRNPLSKIEKVSFLGLESLTHLSLSDLPNLREVSPYSFKSLTSLLELDLSNNPNLKSLSSDMFFGLKALQELNLAYSGVASLPKDIMLHLPSMKSITWGENIRCLKTVKESIFHAQKGRVRKEVLLCHDDNGAVPAQDIL
The following text describes a protein:
Function:
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.
Subcellular Localization:
Cytoplasm. Postsynaptic density.
Sequence:
MENLRMCKDSAPYQGNAGVQEMLAPLKKQPEEELQCLEMTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFSLERTLEELYLDANQIEELPKQLFSCQALRKLSIQDNDLSNLPTTIASLVNLKELDISKNGIQEFPENIKCCKCLTIVEASVNPISKLPDGFTQLLNLTQLYLNDAFLEYLPANFGRLSKLRILELRENHLKTLPKSMSKLAQLERLDLGNNEFTELPEGLELIQNLRELWIDNNSLQTLQGATGKLKQLIYLDISKNRIESVDTDISGCESLEDLLLSSNLLQQLPDSIGFLKKLTTLKVDDNQLVALPNTIGNLSLLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLTELPREIGNCKNVTVMSLRTNKLEFLPEDIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPDTKQRVLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFDFEEKKEEEAPGKLKVEINLKRYPTPYPEDLKNMVKSVQNLVVKGSLGSSLENSMPTPSAEQNLKEKYEHKWPVSTKDMKSEASNREHKEFQKSQISDSGNIRSFSVDVAKRKEKEEHSERPEQEAFGHRPNEMRIAELRPSLIETPLYPPKLVLLGKDKKESTDESEVDKHHHNSVSSGTYSDYSPSQASSGSSNARVKVQITAKEAVNSSMWGNRLTQSFPQPLETKPLLSQREPAPVGNLQQRNDRQALNDSFTENWNDSSHYDNTGFVAEENTVANPSSNPMLNAKSRSTSAHGRRPLIRQDRIVGIPLELEQSAQRNSQESDVSSSNPWQNWTRTPSPFEDRTAFPSKLESSPVSSPLPERKEHKQQSLETPNTFSSGATWEFHDSTTSRSMGNVFSHNHCRPESAKNSVSKSTERLAPLMKDLKTGRFKKSQSIDEIDIGAMKVYNIPLQYDPRNVMQGRHERQDLGMVQEQSMSRSQSVPMLDDELLGYGSSRGHQQKHITKKVYQFDQSFNPQGAVEVKPEKRAPPPFSYNPEYAAQTKTIAKDLISPRGYRGYPPLEQIFSFSQPSVNEDSVPPQFSNQGSRPGFLKRADSLASATEMAMYRRVSEPHEPPQTDRYGRPPFLGAMDRQNSMSVAESQFLKRNGRYEDDHNIYPEMKTQTSSYPVKTLTQRRPLSARSYSTETYGTTQTRPVSARPTMAALLEKIPSDYNLVNYGDKSFENSDIKSRQNAGKIEESCNKMPADWRQQLLRHIEARRLDRNAAYKHNTINLGMLHSGSFPAMHAGKSMTLTMQPRPFFQDIPLQNTPSQQSNILDNGQEDMSLGQWNPYPLGRRDVPPENHTKKLPEALPNGLHYPQAGSHIQTLMGSQSLQHRSREQQHYEGGMNKVTIQQYQSPLPIQIPSAQRGPQSGRCLIQTKGQRSMDGYPEQYCVRIEKNPGLGFSISGGLSGQGNPFKPSDKGIFVTRVQPNGPAAGVLQPGDKILKANGHNFVHLEHEKAVSLLKNFQTTVDLVIQRELTV
The following text describes a protein:
Function:
Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.
Subcellular Localization:
Nucleus.
Sequence:
MSECGRCGHPVYFAEAVQAIGQHWHRACFICSNASCSRSLDSRSCNDNNQKPYCNHCYKSLFGPKGVGYGIGSGVLSTATNGGSISDLHINTYNNNNNDDGYKISYGIDKADPVTSSISYGVNKNDPVTSSISYGVARDDFRPRIFSSYLSKLDDRFVERNGTVEATIIRGTGSLSPASTEASFDSSDSSEPCKFTVRHRIAMAAAQQMKNTSCGRCGKTVYDAEKVLAGGQIWHKNTCFSCFNCNKRLDSRAQNEKEGKLYCATCYARNYGPKGYGHGVGAGILQLHHAGRNVLNQPQGPDIFENRKRRRERQLTIRPFLPSSHHPPFASSAEYKENQLMMSDFSDDQAARKTRVLTASPEDLNTSSEDDSVEAAVESFKKAPIKQASISVDITGTVEPSGPLSAGDKETRILPKHEFSVEELSDLEDDQLISGSAAVMPDGKAPHFPQQPVARQNDDGSLELECFLEASPLPDIKWFYDTTEIKQGGRFSYRLDNKGNDAFSAVLQIKDLADSDAGAYRCAIVNPHGKGNANFNLKLTGFSSPTFVEKPQISSRDDGRVMVMEFRAKSILKPTFVWQKGEEIVAESDRVKIVLREEPNQVYYAALEIREPTKEKDAGQFVCTAKNESGKLTATFTVKFEVPQGAPTFTRKPQILQKTSDSGDPAIVFDIGFQADRNPEVIWINAKGKKMKESTRIKFNLSPDGGANTFTAQLELKNYKAKDSGTYTCNIKNDAGEANVELTLNIEGPLDDGADDGSEA
The following text describes a protein:
Function:
Structural protein that participates in nucleocapsid assembly. Plays an essential role in the proper localization of the major capsid protein VP39, and the minor capsid protein 38K into the capsid assembly site.
Subcellular Localization:
Virion. Note=Present in both the budded virus (BV) and the occluded virus (OV). The occluded form allows the virus to be transmitted from insect to insect through ingestion of contaminated food while the budded form is responsible for the dissemination of infection throughout the insect host.
Sequence:
MCSTKKPIKLDLCASVKLTPFKPMRPPKPMQCWIHPRRANCKVTRPRNNYSDPDNENDMLHMTVLNSVFLNEHAKLYYRHLLRNDQAEARKTILNADSVYECMLIRPIRTEHFRSVDEAGEHNMSVLKIIIDAVIKYIGKLADDEYILIADRMYVDLIYSEFRAIILPQSAYIIKGDYAESDSESGQSVDVCNELEYPWKLITANNCIVSTDESRQSQYIYRTFLLYNTVLTAILKQNNPFDVIAENTSISIIVRNLGSCPNNKDRVKCCDLNYGGVPPGHVMCPPREITKKFFHYAKWVRNPNKYKRYSELIARQSETGGGSASLRENVNNQLHARDVSQLHLLDWENFMGEFSSYFGLHAHNV
The following text describes a protein:
Function:
Hydrolyzes acetyl esters in homogalacturonan regions of pectin. In type I primary cell wall, galacturonic acid residues of pectin can be acetylated at the O-2 and O-3 positions. Decreasing the degree of acetylation of pectin gels in vitro alters their physical properties.
Subcellular Localization:
Secreted, cell wall.
Sequence:
FYNWNIINVGYCDCSSYTGDVEAADPTTNVTRRGARIFDFVMEDLLSKGMANAENAILTGGSAGGLGAILHCDGFRSLLPNTKRVKCISDSGVFLHAKDLPGADQRAEYFAKMVAYHGVTKSLPSPCTSRMNASLCVFPEYIVRDIETPIFFIESAFDPYQLIHHYFSNASTWENCTANLEVCTPSQLQTMKDYGITLRKTLQEFGVCKPKSVGMFVHSCYRHGNWYDDLTWTRSALLGNKTIAQAVGD
The following text describes a protein:
Function:
Involved in the maturation of specific proteins in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEQAKARSDKNHDPRPQHEDEVGDVPRVRNLLLRSMCAVYLMAFVSFYCQAEGLYGDGGILPASRILANGTLKERLSLLQLAPFVGLGHGHEAIDLLCLVGATVAFLGLISRAHCRLLSFIVMWSVYFSLVQIAQSFRQQADHLLLEAGFLCILLAPTRLTDRRHPMEAIALLLLKWLVFRFMFASGSVKLASGCPLWWSLDGLKRHYETMPLPTSYSWYTYQLPDVFHRLSTIYVYLSELVVPWLFFAPSRTVRRFAVWWHVFLHLNIIGCGNYGFLSPLVLTLLVALLDDEDELVVWVQDRLAVDDTRRRAGRGRTAARQTNSTDDSADRYGGRLVKAISLLMVVGSWLCFSVGVSKDDGQLTFQPTFTQDQYLNVMQTMIRAAPLLVFVLLVKQFLKLLSSQDSVGSLAEGMRQFSKNLGLLISTIVAFTVFFMSIVPHSRLLPSTAVTSPVMTRAYGGLHSLYVVNQYGRHLTKMRPMRREIILEYGDELNGTWHEYGFQYKPWTVERAASLPYGWLHFPRFDFKFYDAAGSKSDAQKWIYPLVQRLLDHQQPVLDLLDSRHVPAEAPRYVRTSLYRFAYTSFADAAAGGFWTRERLTDYFNVFSREDAHLRDKLRQMNFRTAAEQSSSGGGSWNWLLRWLLDAVRRFVGAIEGSYLLIGLFVAAGMVLYTQQQQQQQRVGQST
The following text describes a protein:
Function:
Required for the formation of DNA double-strand breaks (DSBs) together with nenya and vilya during the meiotic recombination process. Plays a role in DSBs processing into crossovers. Plays a redundant role with nenya in chromosome segregation during female meiosis.
Miscellaneous:
MISCELLANEOUS: Nenya, narya and vilya contain a RING-type zinc finger domain and are named after the Three Rings of Power given by the elves of Eregion in J.R.R. Tolkien's books.
Subcellular Localization:
Chromosome. Note=Localizes to DNA double-strand breaks during female meiosis in both nurse cells and pro-oocytes. During early pachytene, colocalizes with vilya to the central region of the synaptonemal complex (SC).
Sequence:
MFRVHCNKCFRHRKTDPAVPFHLTQCRHVICGPCLGQSSLEKNCPLCGQVLKAIQINRDMPTSVANYFADPLRFQQIYRKISKFQADQRASDNLGFYRQLQQLEQNKRQLEGFCKMEAQLNQKVVEEKKRIAELRTYIAYHENAQRMTRRRHSAGERFHTPEFKEAWNTSISTSDKSPSDMPSDSSRRSADLDTQSTRRRSFGSDTKGFRL
The following text describes a protein:
Function:
Is probably involved in a pathway contributing to genomic integrity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MNFLLSCKNLAALTVLIGSVSSLLTPEKLEISAAFPTNNQFGIVFNGQPNKILLKVLNLGKDPVEDVMRIHQVWNEFREIGGKERLLRKGAPVPSKRTLPPKIEPYIIPYMFSAEEREGNIGLRIWVEWSGPKGKKHQSIAYDSTVTIQEPPTRWFDPQLILLYIILASTFGGIGYMVYSSYVVPVKPARSLKSKRSAEGSLQSSSKVSTPTGGAYEEEWIPAGHSVRSSKKTGTETGGEESSGAEGKARRRKR
The following text describes a protein:
Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the sulfate conjugation of phenolic compounds. Does not transfer sulfate to steroids, dopamine, acetaminophen, or alpha-naphthol (By similarity). Except in mitochondria, where it can add sulfate to cholesterol producing cholesterol sulfate, which alters mitochondrial membrane organization, and impacts protein complex mobility increasing state-III respiration, thereby modulating mitochondrial respiration (By similarity).
Subcellular Localization:
Cytoplasm. Lysosome. Mitochondrion.
Sequence:
MALAPELSRQTKLKEVAGIPLMDPTVNNWSQIQTFKAKPDDLLICTYPKSGTTWIQEIVNMIEQNGDVEKCQRTIIQHRHPVIEWARPPQPSGVDKANAMPAPRILRTHLPPQLLPPSFWTNNCKYLYVARNAKDCMVSYYHFYRMCQVLPNPGTWNEYFETFINGKVSWGSWFDHVKGWWEIRDRYQILFLFYEDMKRDPKREIQKVMQFMGKNLDEEVVDKIVLETSFEKMKDNPLTNFSTIPKTIMDQSISPFMRKGIVGDWKNHFTVAQNERFDEIYEQKMDGTSLNFCMEL
The following text describes a protein:
Function:
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
Subcellular Localization:
Cytoplasm.
Sequence:
MDEMKRENEALRAKLRSCSTLNTIYHETQQEIARLNQLVTSKDGIIADLRARLGKYEKTVVIEGEEPYIVGPSKSLIESLCKEICKLKQKLKDLEKDTAQKLETRDKEIQRLQEKLKERDQELLTIRERPEQEKEREIQQLRTTLAERDRTQATRTVLCNSLAEEADQLRAQLGATVQVCQELLGRLENEKNKTAMTDQRTQVHETSDSPEVPQLNVIISKLEEENDQLKKRVAYVESLNSKWQKYDSSREEYVRGLCQKLKESNGLASADPTLTQAPTAGHVALFQQEIVRLNGLLQDKMMECERFSRERDDNARRDQEQIQMLEQQVLAYVEDFKSERADRERAQGKIMDLQDEVGRLQLQIRSQNVQEASTSRHKKIMVLKKASHRQTETAEPLRNSPPETSSKRTISNTAPQGAAELQCPRCFIRFDDEHTTEYLKHWDECAKL
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPPHEDALDAGAVDVLTFRLHPLAVLKLSHRIREFVHLHDDQYQQARMSGCVIGVRRGGTVDISDTFDILHDPDPGTFDRALLEKDQEIYKKAFPDLSVLGWYSIGTNVHATDTGIHHGDYTDMQIHQTLMDANGTAFYLLLNPAINFSHKDIPVTIYERVLCNSDGSPPVSFVQGNYTVEIVGAERISLDHADFLYPSPCVVFDVLAPPLGEKKNAFRTMLFETPSGFAMFRVSDVLFRYPEDIWSSFTDPHTAHQVVRTIGFIEVGDKSVVWDNDIGPGEDIEHFILKFPIKSLVVPDAQLKFIIEKNLNISCWFNGRIVPELIWGLNYALDEFVPREKGNLSNERHFPLSKQLHEQLKAYGFSISPQLINREFITSFGYLNYLERTSNCISGDLHQKFDRFFCGLEMSEGEFVRGVAHRLHSMEEVASTPGRREALSNAEFLLAVPKKKCNTISRLKRMEAEDRGTGLGHPWVCAAAVAVGFGVMAGLCIAMKRAN