lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSKVMKPSNGKGSRKSSKAATPDTKNFFHAKKKDPVNQDKANNASQITPTVPHSHPSDMVIPDHLAELIPELYSFQQLVDSEKRLDHFIHLRNLHMKRMVAQWERSKLSQEFLYPHLNFPNVKFLRIFISNVSENQPWQMDTNNEADLMALENATWTMRIEGRLLDNVQANDPAREKFSSFIESIVVDFKNKENDNVPSTKFNAAPEENATEGPSDKKLNLNLPLQFSLPNGDNSTTTNTDQNNATMGEETAKKDMSSTTPKLESVKWQYDPNNPVDFDGLDIKRVGSENVECTISILRKSSPEEPFMSYSPQLTAIIGLKSGTSHDAIFSIYKYIHLNELLTNDESAFENLMGNRNNHNSNTSTSKMLDAASSQVSIVKLDTQLITLLPSSLKESSPDTMKLTDLLSLINSTHLLPLQPIEIDYTVRVDKASTYGELVLDIEVPDVNALKFNNTQRESQIGAAELNENARELEQIKPKIALQDKEITSVLSNLHESNKRYRFFKKISEDPVKALNECIASTSNALKVLSGDEGYNEDMVRRANFYKENEAMLRENIEVILSNGRM
The following text describes a protein:
Function:
Plays an essential role in the initiation and regulation of chromosomal replication. ATP-DnaA binds to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex once per cell cycle. Binds the DnaA box (a 9 base pair repeat at the origin) and separates the double-stranded (ds)DNA. Forms a right-handed helical filament on oriC DNA; dsDNA binds to the exterior of the filament while single-stranded (ss)DNA is stabiized in the filament's interior. The ATP-DnaA-oriC complex binds and stabilizes one strand of the AT-rich DNA unwinding element (DUE), permitting loading of DNA polymerase. After initiation quickly degrades to an ADP-DnaA complex that is not apt for DNA replication. Binds acidic phospholipids.
Sequence:
MLTKSMREVCATGMSSTQGSIETQEAIERFAEALHQRIGADRYRLWFTHGVGFDLEVGESPDDGKPTVVVVIRTSGPFAAQRMGNSFATELRAAAMIACGERARYRIDVEEAAQPEPKKRTRAAKVAAEKKATTKSGARRSSTRQTSTRATAGRQSGGRQSSGRRGSANSLASLLAQSTATGSDQSGGSRGGKGRSRGRVEHDPIAASELPTDERFDDEEIEDEEVAVSTPRSSKSKLPPLPESQPTGGRTLDSFITGPCNEFAFSAAMMAVATPSVATPLFLHGPTGTGKSHLLAALANEFRTRRRMRRVVLLTAEQFTNDFVVSVGSTGLPAFRRRYRDVDALLIDDVHFLAAKTATLREALYTVETLASAGKPLVFSANLPPSDIRGLTGEVAGRMASGLVCPLAALDQETRFKLLQRMVATRCVLGCDNTLLEEVSELIGGDARAAGGIANLIGMLQRMFRREPTIDEIRRYGGDLLRSTQVAPTLRSIEKAVCETFGLEGDGLRGKAQTRRVSEPRTLAMYLARQHTGSAFTEIAKHFGRRSHSNAISAISKVETWLSSGKPIGAGDGAMSAQDAIARVESRLRVG
The following text describes a protein:
Function:
Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 47 of tRNAs. Acp3U47 confers thermal stability on tRNA.
Domain:
The N-terminal domain binds zinc and is important for activity.
Sequence:
MTENAVLQLRAERIARATRPFLARGNRVRRCQRCLLPEKLCLCSTITPAQAKSRFCLLMFDTEPMKPSNTGRLIADILPDTVAFQWSRTEPSQDLLELVQNPDYQPMVVFPASYADEQREVIFTPPAGKPPLFIMLDGTWPEARKMFRKSPYLDNLPVISVDLSRLSAYRLREAQAEGQYCTAEVAIALLDMAGDTGAAAGLGEHFTRFKTRYLAGKTQHLGSITAEQLESV
The following text describes a protein:
Function:
May play a role in cell motility and cell adhesion.
Subcellular Localization:
Secreted.
Sequence:
MLVAGLLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRGFNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRDAVHAALFPPLSMSAPPPPGAGPPTPPYQELAQLLAQPEVGLIHQYCQGYWRHVPPSPREAPGAPRSPEPQDQKKPRNRRHHPPDT
The following text describes a protein:
Function:
Transcription factor, involved in posterior embryonic patterning, morphogenetic movements of the posterior hypodermis, and cell fate specification. Binds to the 5'-TAGT-3' motif in regulatory elements of genes, including Meis protein psa-3 and microRNA mir-57. Involved in a negative regulatory loop with mir-57 to specify posterior cell identities. Required for asymmetric division of the T hypodermal cell, acting via the regulation of asymmetric expression of psa-3 in cooperation with ceh-20 and the Wnt-MAPK pathway. Involved in the regulation of the onset of non-apoptotic cell death in the linker cell, acting together with the Wnt signaling pathway. Involved in promoting embryogenesis, in concert with orphan nuclear receptor nhr-25. May regulate expression of transcription factor dmd-3.
Subcellular Localization:
Nucleus.
Sequence:
MISVMQQMINNDSPEDSKESITSVQQTPFFWPSAAAAIPSIQGESRSERESETGSSPQLAPSSTGMVMPGTAGMYGFGPSRMPTANEFGMMMNPVYTDFYQNPLASTGWYSYGQPYQFTANYSIPSLDGNLSDITIPTTAGSSAATTPNAAMHLPWAISHDGKKKRQPYKKDQISRLEYEYSVNQYLTNKRRSELSAQLMLDEKQVKVWFQNRRMKDKKLRQRHSGPFPHGAPVTPCIERLIN
The following text describes a protein:
Function:
The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
Subcellular Localization:
Mitochondrion.
Sequence:
MALRQVLQRTAAPMAMRLALRPLSTSASLFAKRYTESHEWVEVSGNIVTVGISDYAQSALGDIVFVDLPEIGDDKDIGEDAAAVESVKAASEIYAPVAGSIAEVNEALRDQASLINEAAESEGWIFKLEAEDLAAVDSFMTKEQYDKYLESGEL
The following text describes a protein:
Function:
DNA-binding protein that is probably part of the rDNA transcription apparatus. Acts synergetically with the RPA49 subunit of RNA polymerase I during rDNA transcription. May participate in mutagenesis control.
Miscellaneous:
MISCELLANEOUS: Present with 19000 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus. Note=Colocalizes with FOB1.
Sequence:
MTTDPSVKLKSAKDSLVSSLFELSKAANQTASSIVDFYNAIGDDEEEKIEAFTTLTESLQTLTSGVNHLHGISSELVNPIDDDKDAIIAAPVKAVRRKIERDPNAPKKPLTVFFAYSAYVRQELREDRQKAGLPPLSSTEITQEISKKWKELSDNEKEKWKQAYNVELENYQREKSKYLEAKKNGTLPPASLENGPTHAPVPIPFSLQHAAEPPVEKRPHDDDGSSEKKKKKKKKDKKKDKSNSSI
The following text describes a protein:
Function:
May be involved in chitin synthesis in the pharynx during larval development.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMNTLDHRPLGRMETMEGKPDEDEVPTSSNSDAKGKGYYYSSGTVPTDDSTLEEKCQQKTFDPSCPTPKTPVIVPNREFDPNFSTVTENKGWDIFRLLPPKPDRLGHGFWHDASLQVLKLATFLVLFLLTLGSAVVAKSTFILMTSAIGWGGQTITICNQVISEATQNTVKLKNAHVVKWVWATLLALSAPEALCFVRSMHRTMFRNVKRPTFIQFVFVLIIETFHSIGVGILVFRIFPDLDAVTAAQLTNAMCFVPAILSVISRKPNKSALLLVIIDFAAIAAQSSGFWALPMFLPNLQKHLVAIPVSLTLISLAWWQNFVHRDSVFPPVRTLAKFAQRLSERRSKTYAFVSLWKICIYVVCCFLFISSRMKIEDMLQKDPFGEKLLSVAGHDMNQTQIEKFQLRINQMIEQANREAGFYAAAEKKKQPPKKQPKADEAEQVDAGEYMMKRFKRFIGDAGENEEEEPEEEEFSSYNIYSNYVERNQLTMAYDALWLVIFQFGAVFVCYHSSKFACKVMMQRMGFALPMALSVPVTVLLLSTNCRMRQKDSCYGTNVLTVELFWQCNGASMSLADFILTPQTWIWLCWLASQFWITIHLWNPKHERLAKSEKLFILPYYIGAFVDQSLAFNRRRDDKAKIKAEDLEFDAEDSSLTYETIPGLQNKTPPSVCSASSSKLENGLIRDSASSADAITKIYACATMWHETGVEMTCMLKSLFRMDEDQCARRNAQKYLKVIDPDYYEFEAHIFFDDAYDVNEYGEPEINKFVKQIVNVIDQAASAVHQTQMRLKPPKKAKTPYGGKLTYIMPGKNKLFIHLKDNQKIRHRKRWSQVMYLYYLLGYRLMMKVDDPSRKEIISENTFILTLDGDVDFTPSSVYLLVDLMKKNRRLGAACGRIHPRGDGAMVWYQKFEYAIGHWLQKATEHMIGCVMCSPGCFSLFRAYALMDDNVARRYALKSEEPKHFIQYDQGEDRWLCTLLLQRGYRVEYCAASDAQTFAPEGFNEFFNQRRRWIPSTIFNIMDLLKDYRNVVRVNESISIWYIIYQLVMLISSILGPGTIFVMIIGAISISFSIDTLISLVIVSIPVVVFIVVCLTAKPEHQLICAQTIGAIFAMLMTAVVVGTSLQLQKDGLLSPHSMFTVAVATSFLTAAILHPLEFTCIIPGTIYFLAIPCMYMLLPIYSVCNMHTVSWGTREDPRPTEKNTLAKKTPGNLESGDGAGNSENWCTRFLCCGRGTVHPMTMVINEKLNEVIKKVDRLDRKHHPSLARRASILSSTGGTIQIDKCSEADEDEQAEIEDALEMSNQSHAAKKNQKWKQAQSEAWLADKALKRAEREYLEPEEESFWNDVIERYLSPLIMDGKDMDRLRAGLIAIRNSHTVYFLMINIVFIISVLVLQIHKDCLNIEWPLGPKFNHTVRPCYANHDDNQKEEVWVMTRLQLEPIGLVFLIFFVSILVIQFLAMLCHRFGTLAHIIASTELFCFRKTMDRLSEDELVAQNAVEIARELQAIRGIDENAHNIDNPTEDRGISRRRVVQNLESSRKSMMKRKTETLDAAFKKRFFALSSEQTPDPAGFSARDNSKRLTLRKGTIRALEHRRDSLFGTLDNRKDDEVDATSMRGPAQRRLERLFTAQQDQNSPTSDGNRRKSNSRPWDQPTSSATSSGDVELRRF
The following text describes a protein:
Function:
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MAPLLAYESQQVLELFHSDGLLVGARGLGVDRLLGHFLRLHCHPACLVLVLNTGPAEEEFFISQLKLEEVEHLPRRVTNEISTSSRYDVYMQGGVIFATSRILVVDFLTNRIPSDLITGILVYKAHRIVESCQEAFILRLFRQKNKHGFIKAFTDNAVSFNTGFCHVERVMRNLFVRKLYLWPRFHVAVNSFLEKHKPEVIEIHVAMTPAMLAIQSAILDIINACLKELKCYNPSLEVEDLTLENAIGKSFDKTIRHYLDPLWHQLGAKTKSLVQDLKILRTLLQYLSQYDCVTFLNLLESLRTTEKTFGQNSGWLFLDSSTSMFVNARARVYRNPDVKTNKKHKTSENMEKKEDQEMKRELVLESNPKWEALTEVLKEIEIENKNSEALGGPGQILICASDDRTCAQLREYIAVGAEAFLMRLFKKTFGKDDKAGEVWLKLRKEVDPKANAKTGKGSKAPKAKAKLSAKQTKTQDLTLTQMLEKPEEEEVGEVEDRKETSSQESCLEETKPEDFDLNLSSNAAYGILKEPLTVIHPLLGCSDPYALTRVLHEVEPRYVVLYDAELTFVRQLEIYKASRPGKPLRVYFLIYGGSAEEQCYLTALRKEKEAFEKLIREKASMVIPEEREGRDDTNLDLIRDAAPAHACTDTRKAGGQEQIKEHQSIIVDMREFRSELPSLIHRRGIDIEPVTLEVGDYILTPDICVERKSISDLIGSLNNGRLYTQCISMSRYYKRPVLLIEFDPSKPFSLTSRGSLHQEISSNDISSKLTLLTLHFPRLRLLWCPSPHATAELFEELKENKPQPDATAAMAITADSETLPESDKYNPGPQDFLLKMPGVNAKNCRSLMNQVKSIAELATLSQDRLADILGNAANAKQLYDFIHVSYEKVMSQGKGKK
The following text describes a protein:
Function:
Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.
Sequence:
MLSFQTSDGQIVDASKMIFLKSTVVQNAIIKNRGVAPEVIRLDGVTGTTLKHIIHFLEHYKDAPVEVGIPRELTDFDKEFFQSAGNPELFKMTCAAHSMDIRLLTVATATYIAHMAEGKSTEELRNMFGIPTDSEDEERANEEEQESNE
The following text describes a protein:
Function:
Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity.
Subcellular Localization:
Peroxisome.
Sequence:
MAASSVFKAGLFNHKVAVVTGGGTGIGKAITSELLQLGCSVVISSRKLERLKSAAEELTLKIPSSSPAKVTPIECNIRNEDEVKNLMASTLKLHGRIDFLVNNGGGQFSSPANMMSAKGWKAVIDTNLNGTFLCCREAYNAWMKDHGGVIVNIIADMWKGFPGMAHTGAARAAVDNLTKSLAIEWAHSGVRINSVAPGTIISKTAMENYKEYGPTLFKMSVPFSPAKRLGVPEEISPAVCFLLSPAANYITGATLKVDAGQSLYHSIWEIPEHDAWPEAPEGENTDVLREIMDKTKSKL
The following text describes a protein:
Function:
Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.
Subcellular Localization:
Nucleus.
Sequence:
MATEKAEQLLDQMVATQKALSAILDTSLESTLGNLEAVEKARLLTTLSYTINTLSFVYLKLQGVNAKTHPVKKELASILNAFALFFDRTRIYFEKIEKMAGATRNPASIDRDAAKRFLQHSLAQNPEVKDGIAKARKANALVDLHTSSQADDTQDISTVTDATDASVKGHENKGNE
The following text describes a protein:
Function:
Plays a role in regulating synaptic function, probably by modulation of endocytosis. May be dispensable in muscle for normal locomotion. May be involved in post-transcriptional mRNA processing, in parallel with unc-75.
Subcellular Localization:
Nucleus. Nucleus speckle.
Sequence:
MSVCVSPLVQATILMTEESLTCPQCPKSFSSTKLLQQHQQMFHTDKSVLLSLKSTDAPVGMDRAFICETCGKAFRFRSNLAEHRSVHTALKPYVCKFCGKSSRLKGNLTKHILKHHKKEQNEAIAKDDIIVKKAPKIVTKDNGPTTNGSTPTTSTATPSVITVSSALASSNGHNNNNNNHAVNNNLRTIKMELEDPDYNLIAKSAPTPVVSKIVATHTVTPRSRPTPKDIKEILETIAPSVGVSETPEEMCLLPKDASSESDRSVLISLGFDFGSTLSLNHQQLQQVVRELKGELSISPDTVQSDHSDDFEQDSPPPMAIANISTVGGEATLAAMIVAATNASGQRGDGTPDSTDTQKGCSPQRELSPESDPSTSSGDSCPSPPKMLHCKECGTLVRKSSHLPIHMTMSHGYPPPLVAAPVEEKPAPEQPVNASSLHNELRVISNAICELKAQQAATPRVEQALTYIDSRVGKLERSLETALNSIYTLVQLQTGMTSSVNRLREDSTKNFSDLKTRMEMSLSPIKPFQQRFSRERSSSSSVERSPSRERSRSPL
The following text describes a protein:
Function:
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
The following text describes a protein:
Function:
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNKAIASKILITLGFLFLYRVLAYIPIPGVDLAAIKAFFDSNSNNALGLFNMFSGNAVSRLSIISLGIMPYITSSIIMELLSATFPNLAKMKKERDGMQKYMQIVRYLTILITLIQAVSVSVGLRSISGGANGAIMIDMQVFMIVSAFSMLTGTMLLMWIGEQITQRGVGNGISLIIFAGIVSGIPSAISGTFNLVNTGVINILMLIGIVLIVLATIFAIIYVELAERRIPISYARKVVMQNQNKRIMNYIPIKLNLSGVIPPIFASALLVFPSTILQQATSNKTLQAVADFLSPQGYAYNILMFLLIIFFAYFYSSIVFNSKDIADNLRRNGGYIPGLRPGEGTSSFLNSVASKLTLWGSLYLALISTVPWILVKAMGVPFYFGGTAVLIVVQVAIDTMKKIEAQIYMSKYKTLSAVGF
The following text describes a protein:
Function:
Probable serine/threonine protein kinase which may function redundantly with MPK1-independent branch of the PCK1 pathway that is presumed to be required for the tolerance to high temperatures and staurosporine.
Miscellaneous:
MISCELLANEOUS: Present with 1590 molecules/cell in log phase SD medium.
Sequence:
MNSTPPTSPVTRVSDGSFPSISNNSKGFAYRQPQKHKSNFAYSHLVSPVEEPTAKFSEAFQTDYSSKAPVATSEAHLKNDLDVLFTTPRFYSPENLALMFRLSNTVSSLEFLDEFLMGILLAPEMDFLSNPSYSLPSNKLVGQGSYSYVYPISSSASSRCNNDSGVVLKFAKSQHKSKVILQEALTLAYLQYMSPSTNESHIIPFYGLTYITKSHFRRLRSNECVPGLILPKCEMSLYHFNTAVSHKLSLITKRKIWWRLMKQMIDALKSLKTNGIIHGDIKTANILITEMHVLNGGHCKDFDFYLADFTSAFHINQTPTDLNTTVEYCAPELIDSSSDHVPTFESDLYAVGLCLLSFISQHEPYNELQALVSHGSSPGIGSSSIQQSQWLINALLKKDPINLNMLRNDLFQDWKSELALLSRILVDRLPLENLITILDSNYI
The following text describes a protein:
Function:
Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.
Sequence:
MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARSGVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYTEETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIADISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKMPPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase Cdk8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAGNFWQSSHSQQWILDKQDLLRERQHDLLSLNEDEYQKVFIFFANVIQVLGEQLKLRQQVIATATVYFKRFYARNSLKNIDPLLLAPTCILLASKVEEFGVISNSRLISICQSAIKTKFSYAYTQEFPYRTNHILECEFYLLENLDCCLIVYQPYRPLLQLVQDMGQEDQLLTLSWRIVNDSLRTDVCLLYPPYQIAIACLQIACVILQKDSTKQWFAELNVDLDKVQEIVRAIVNLYEMWKDWKEKDEIQMLLSKIPKPKPPPQR
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MANNERRKKNAPMGKRIGHVIRRGPFHQIIRPFRQNRNLQVSPFSRVWTRFEFHLSSGHDTNSTALHNTSPTMLFVRTLVLAMAGLVAAKPPVEARTAVIVDKNTDLAQYSQFFDDAEHLLDTVTVIDVKDKSFDLFTYGYQAYDMVILFPPQVKSLGPALTSRKLLEFFNKGGHILSITSPEHTPESIRDFAQEMGISMAPKFHKLVDHFGETGPNHDSLTLDTVNSVISSAENVVYSGSAAYLSNNPQLVPLLTAPSTSYVYDYKEDEEDEENAGTMGTPWITGSQGFPAVGFQGKNNARFAWVGGDIMTNEQYTAHPGNRQFMKDVVEWVSVAKNVISPEYIRHNLAATPDVLNEKIYKVNEDITYSVALTEWDNVKEDWVPFIADDVQIEFTMLNPYYRLTLEQTGTTNFSAIYSTTFKIPDQHGVFTFNLDYKRPGYTFIEEKTRATIRHTANDEWPRSWEITNSWVYLTSAVMVVIAWFLFVVFYLFVGKADKEAVHKQ
The following text describes a protein:
Function:
Proteolytically removes the C-terminal three residues of farnesylated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLSLVQDKIAFLQSALDDPAIQWKKLVLALLWLVYAFETLLSLRQYRLYSLETPPATLASHVDLDTFKKSQVYGRDKARFGFFSSAVSQLISVALVHYDIYAWSWTLAGTILTHFGQSDSEIPRSIVWMVIMFVIREVPGMPLTLYRNFVIEERHGFNKMTIRTFVTDTLKEWMLGFVIGVPLISALLWIIRWAGSAFVSYVVVFLFSFQMIAMVLYPTVIQPLFNKLTPLPQGALRDRVVALATSLKFPLKHIYVIDGSKRSSHSNAYFFGVIPGGNKHIVIFDTLIEKSSADEIEAVLAHELGHYANNDPTKLLVLSQVQIWFTMSLFTLFINNVSLYRSFGFQVGPSLLEKVAGTRSSQLLNYLPVIIGLELFQLVLNPTDALVKFLLNSAIRRMEYAADRFAATLTRPGPTRSELAAAAEFNADSHNAAVKVDPNQKQEYVDLLGRALIKLHVHNLSTMHHDPLFSAYHYSHPTLAERLDALQALRPHLKKHK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to vcp/p97 recruitment for extraction and degradation of the incomplete translation product.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSKQQRRKGNAKNASSAAAHEYLAQGGATFVGLTPEMNIFEVASSNRLHQVVEIDDETRIVMKKLTKKDCQTREKGLKELMELINTENSSIESSYEHFCGLVAQLTTDGSPTVRMLTMKVISQFLTKLKKSASKGLKKIIPFVLFAKSDVTNGVAAAASAVIRDGFDADKKRQVVELFVPNTFDLAAKIAEGKHELSLPAEYDASEDLETRKMRLETQSLNTFLSYIKEYGNESKLWEEPARKLFSNSEFIKKTFAGKKEALKVQLLNISYKFSDNIEVILSNPVISTYIQASLDAQTFSTECATAWEGILILLPDERFHAKCSLQKGIYPRLLNLIRKKGNHWRVLKHYLLPAVSVLLQKLENPALITSIITSFTDNLPWQAEASMNAIHCWFCTFSDFVKWILGNDRINLEILKDLSPLIVEMSNQSMHFNTAEATECISGLIHWIIEKKVLENPAEFFDLLKTSIYEVAPPEKSRLFADSLTLPAKHLELAHLHGNLLSNPDVDFHIIRNLARASNSEYFEETCRNINNFEFIENSDRFDMLQAVEIVKLIEMKPSLSLQIKNNHVGRQLLLSENSEIWEKSLKNVPAGVFQEMVNFWHEKRNGKAIAQAVNFLKKMGIQLDTNAAAENVDFLISLLQSLDSKEDPEERKNLVLKLLSALFDAEDEPKLEHFESLKSHLNGDFEQFFEKLFANMEEEDAERVLEIAARFDKLVGFCDADSRGEIAGKMILGRREFDEMSEKLHFLELDVLTVSQHTTIITDALSRPIEHLEEKEATKMVKELGRLALFSVASNYNSSIHQLFAWQMIRVISALGNRYCLKFLDEELQQLRIELEKRVIKSEEIQKLINDGCCCAPNFITDTYGIPEKRQKFEEYSEDMDTKIETIYLKTDTPLEYVEKVFEASQSENSFPLFQFDQSKKYEWLANLTFVKRFIQCGGEIFRAENLEFRDFTLCGIITVLDTSTDILIDSPHSFSENPLLEALTTLYLELFVVLTDATKRGAYSEQSVEEWNEFYTPTIHTYCIRLFRTIRRDQQPTPFVRALLRALFVISEFPTSFSNDDDVANQEFIPELSVFKYPAFQESCIAQAFSLFASNNEHIQLIAYSVARLLMPIMFKLENAAALKSNEDSELPVSTNRRKLSLPVMISKSYPKDHHNPHVGPLLLDLTLLPLENTKDSGFSQEHRVAYCDVIDPFFKNALNALMLDQPFEFRQVPIGCRIPKSQERAYYLESDLSASPIFFDKFASRLLFKSMTLLPAAIRLFYKGMPNCFMPMFQETVTKYASRLLIEQELGKVREAKFEGEMKVRTVPVTGEIIAEYVVEETKMKLTIGLPPDYPLSVPSLTLDKAIVKTDRAKKWLLQLNAYLFHQNGAILEGIEMWKRNVDKGVEGVEDCTICMMTVHQQTHQLPKIKCKQCKNKFHSNCLYKWFESSNQSTCPLCRNNFT
The following text describes a protein:
Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MADTENYDAGSENSSQASEQEKALALGAQAEFEKKNYAAAIQLLSKLESSRPQDPKVIHNKAIVNCFKAGLTNISQLRKALTSIAKQLQCNLEDPKTLVDVDQCYVFYNEAVTLYFLRQYPKTLQILTKIFSLVEQLDESLARQVCFLLAEVYLRLNFPIKTLKMVHFMETSLLSHGAKLKSTLPLERERDKEKDCEGKEDLKSSFGDELLIPPGVRIRLQRLKIRANLSLSKREEAERELALLSEIDPENAATLFLKSKTLFVKANYAESLKQFKLPEDDGLFKERGESDVVMYHNNTGCVYHAMGKYHLACLHFQKSLNKSSELLAEFPKPVSGDPISNRPLVTIGSNYKYELLYNMGVSLLYARKPADAFDCLIETVQLHHRDPLIWLRLAECCIQVHKPENRKDFRLTERQREIVKATAGFGSHRKVILSSRISNDNCKSSENAAIPVPTLEFGTLALRNAELLLNKLTIPNSTEGICLINLLSNVGNKDESDSKGKPDLNVTLSEVSTLSKLRKPEFYRNLKNTIIADSSYAALCLGDYLTSLYKAEELLTQPHLSGNHKLLGHLYAAESLVLLNRINEAVPHLHPENVTKLSNFSPSESEITQHLPHTSDWFPLSTQTAKVVLQYNLSTVYAMRGEYDKAGELVRQLWNASKSHGIDVPIQVVTLALYVELQLGRTEIARNIIKQHCPQYR
The following text describes a protein:
Function:
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
Subcellular Localization:
Cytoplasm.
Sequence:
MTISDVPTQTLPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRWGKLSPARDNVVVVLHALTGDSHITGPAGPGHPTPGWWDGVAGPGAPIDTTRWCAVATNVLGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVQADVAALAALGITEVAAVVGGSMGGARALEWVVGYPDRVRAGLLLAVGARATADQIGTQTTQIAAIKADPDWQSGDYHETGRAPDAGLRLARRFAHLTYRGEIELDTRFANHNQGNEDPTAGGRYAVQSYLEHQGDKLLSRFDAGSYVILTEALNSHDVGRGRGGVSAALRACPVPVVVGGITSDRLYPLRLQQELADLLPGCAGLRVVESVYGHDGFLVETEAVGELIRQTLGLADREGACRR
The following text describes a protein:
Function:
May play a role in retinal photoreceptors development.
Subcellular Localization:
Cytoplasm.
Sequence:
MIQSDKGADPPDKKDMKLSTATNPQNGLSQILRLVLQELSLFYGRDVNGVCLLYDLLHSPWLQALLKIYDCLQEFKEKKLVPATPHAQVLSYEVVELLRETPTSPEIQELRQMLQAPHFKGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPPVNSQQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPATCAGLVPSNHLLKRKQREFWWSQPYQPHTCLKSTLYKEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPATWISSDTESQ
The following text describes a protein:
Function:
Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaphrodites.
Miscellaneous:
MISCELLANEOUS: RNA-mediated interference (RNAi) of rsp-5/rsp-6 resulted in fertile animals that exhibit excessive sperm and delayed oocyte production, and sterile animals that develop morphological abnormalities of somatic gonads.
Subcellular Localization:
Nucleus.
Sequence:
MPRLYLGKIPYNARERDVERFLKGYGKINNISMKYGFAFVDFEDSRDAEDACHDLDGKTMEGSSMRLVVEMARGKPRGNDRHGSRSPRRRSRSPRRRSRTPPRRRSRSRDRKRSRRSRSRSSSRSRSPVRESRRRSESRSPSPKRDLKREASRSRSPLPAKDRSRTRSGSPPKNGGDRKRSVSRGRSHSRDGSNRSVSRSPSPGSPKD
The following text describes a protein:
Function:
May play a general 'housekeeping role' in lipid metabolism. Exhibits both diacylglycerol pyrophosphate (DGPP) phosphatase and phosphatidate (PA) phosphatase activities with no preference for either substrate. May play a role downstream of the ABA signaling pathway during seed germination and in stomatal movement in leaves.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPEIHLGAHTIRSHGVTVARFHMHDWLILLLLIVIEIVLNVIEPFHRFVGEDMLTDLRYPLQDNTIPFWAVPLIAVVLPFAVICVYYFIRNDVYDLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGIGIFHNVTKNVLCTGAKDVVKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVFDQRGHVAKLCIVILPLLVAALVGVSRVDDYWHHWQDVFGGAIIGLTVATFCYLQFFPPPYDPDGWGPHAYFQMLADSRNDVQDSAGMNHLSVRQTELESVR
The following text describes a protein:
Function:
May play a role in the regulation of cytokinesis.
Sequence:
MAERASAEMKPKCTPAELMLKVILMGTLSHYETRGMIDDKRLDHMLSAGKQILYKTHQESDVRHGLGLSPDIWQGLTDVFTKAIPVLESQSFIWKSPPAANYEHSSSNLIAYNYFSLVKDIERLNDLCTIARNLLATTKKAQNMAAEKGFDQRVLALVDTCVRVTARGFDGETNARNEERWQKVVNLYKRLLITCLQFLHNFIMHNEQRKMVLWLDLFGYHSTGDSNIIQPKEPLDQASSQPEGLAPIVKTGERIVNPPIRALYDQTAEDLLLETISNFPREPATIKEEAAMLLLANIKDHMEKLLGRDLTAIQEMGKDPDQVKEIRAALTAILGAKVDGWSDLQDRAKDLPPALPDDEPPRKKAILTIDRSPTAGFPRICWSDLPDLNEYGVVAAGDAPIAEEDTTMPRSSQSAAETLQEAKDELMARLQEASQMGDERDHDYDAGDAGTVGDDDSRSLEAVADGSIDEEEEEDDEDDDDYRGRPGDQQRGLLTDIPLVLGPAEIEALPMIIQAGIVDSFGLKGGERTGSRNMQALRCHILLTQETGRNLLRELLIFIAAWDLPDDELYFKMMVQIMDAVLRNGLMSHAYSDFGQPKDIISPAQAVVVKILTHIFRAKYSPASVTGSGQANATKNPAPLSRVDVLTVRYIFTIFRGNIIPETCALIYLQGQIRAGRALPEDFPLNLWDMERVYEGVYQFLEFFAVLTENNDWKNLLVKWEIVYDLVTLIKELEASIPKGQLSQLNLGRNSPSREQQQSASPGPIAVERPYDPSDPDPTDGGTASRPESPPITEDPSEFEWRNLKKLVVLVLSSLVWKCPEVQDQIRRYGGVETILSCTNFDAHNPYIKEHAVMCLKFLLEGNRENQKLIEELEAREVRDDNGMLQQRGLEAVIDKTGKLAIRPRDGQSSS