lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
A broad-specificity exonuclease, capable of degrading both structure-specific DNA and RNA targets without sequence specificity in vitro. Requires two to five unpaired nucleotides in the 3' region for efficient binding and nuclease activity. Binds with higher affinity to RNA and DNA stem-loop substrates compared to single-stranded substrate. Binds to the 3'-end of histone mRNAs and degrades them, suggesting that it might play a role in histone mRNA decay after replication. Can readily cleave the histone stem-loop RNA beyond the -12 (UUU) position in the loop to produce -14 and then -16 oligonucleotide fragments for both the stem-loop and the reverse stem-loop. Cleaves both the single-stranded 3' flank as well as the double-stranded stem portion of histone stem-loop RNA. Might affect histone mRNA 3' processing thereby regulating histone protein expression. Has an important role in development and tissue formation. Might have a role in 5.8S rRNA precursor processing.
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus, nucleolus.
Sequence:
MALIKLARQLGLIDTIYVDGARPDPNNDPEESFNEDEVTEANSVPAKSKKSRKSKRLAMQPYSYVIAVDFEATCWEKQAPPEWREAEIIEFPAVLVNLKTGKIEAEFHQYILPFESPRLSAYCTELTGIQQKTVDSGMPLRTAIVMFNEWLRNEMRARNLTLPKMNKSNILGNCAFVTWTDWDFGICLAKECSRKGIRKPAYFNQWIDVRAIYRSWYKYRPCNFTDALSHVGLAFEGKAHSGIDDAKNLGALMCKMVRDGALFSITKDLTPYQQLNPRFVL
The following text describes a protein:
Function:
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Sequence:
MSDWETVPVGSETPEIKLFGKWSTDDVQINDISLQDYIAVKEKYAKFLPHSGGRYAAKRFRKAQCPIVERLTNSLMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECVADELINAAKGSSNSYAIKKKDELERVAKSNR
The following text describes a protein:
Function:
In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus.
Sequence:
MARKRAAGGEPRGRELRSQKSKAKSKARREEEEEDAFEDEKPPKKSLLSKVSQGKRKRGCSHPGGSADGPAKKKVAKVTVKSENLKVIKDEALSDGDDLRDFPSDLKKAHHLKRGATMNEDSNEEEEESENDWEEVEELSEPVLGDVRESTAFSRSLLPVKPVEIEIETPEQAKTRERSEKIKLEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSASEQDNLQTTLERRFAIYSARDDEELVHIFLLILRALQLLTRLVLSLQPIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKPKTSKGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSEEDEGPGDKQEKATQRRPHGRERRVASRVSYKEESGSDEAGSGSDFELSSGEASDPSDEDSEPGPPKQRKAPAPQRTKAGSKSASRTHRGSHRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKWVCVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERKEKEKKEKRALGNWKLLAKGLLIRERLKRRYGPKSEAAAPHTDAGGGLSSDEEEGTSSQAEAARILAASWPQNREDEEKQKLKGGPKKTKREKKAAASHLFPFEQL
The following text describes a protein:
Function:
Acts as a transcription factor required for formation of the pharyngeal primordium. Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression. Becomes associated with pharyngeal target promoters by the 8E cell stage, playing a role in inducing large-scale chromatin decompaction, prior to the activation of transcription. Binding with target sequences in pharyngeal cells may be repressed by the nuclear lamina protein emr-1. Activates a wide array of pharyngeal genes including ceh-22, pax-1 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate. Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Required for expression of transcription factor ceh-34 in the pharyngeal neurons. Positively regulates the expression of the transcription factor hlh-6 in the pharyngeal gland. Acts in the regulation of diet-restriction-mediated longevity by increasing expression of sod-1, sod-2, sod-4 and sod-5 but not sod-3. May regulate gene expression in the intestine.
Subcellular Localization:
Nucleus. Note=Present in nuclei of all cells of larval and adult pharynx but variable in neuronal nuclei.
Sequence:
MTSPSSDEDIIDIRVIKEEPESEPDSEAEPATTTNSTDSEDSVEQENKKLLETEKNRKREQKHKMLPNGTTSGTSDTGNQVPATSSAASSVDYTAMNAQDYLPTYSNTTLNYQPYQYQTAANGLLNYNNYSQYATANQLGSNYISPANFMQGGGISPLGFTTGTTGATTAAASVATSSASAVIGRSNGRSSSTVAASPADRSYSGVSGGQGQELTIQEFETVTEKIRRHGTYGQSKPPYSYISLITMAIQKSNSRQLTLSEIYNWIMDLFPYYQNNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSFWTLHEHCGNMFENGCYLRRQKRFKVKEREPSRKKRNANSQQLHQQQHIPKMEIKEEDPTSITTTSSLGAYSLIPQISTKKEIKEELKAVQDATAAAANLGLIDPSGTPSAVNHSQPTSVISSVGTLGTTQAQMTLNGQYASPYLYSSDFATILPQSQNFLNNTLYNTTSSYPGIDYTNGVYQNTLYSSTNPNSAANL
The following text describes a protein:
Function:
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Subcellular Localization:
Nucleus.
Sequence:
MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNAENEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD
The following text describes a protein:
Function:
Voltage-gated chloride channel. Chloride channels may have several functions including the regulation of cell volume, membrane potential stabilization and signal transduction (By similarity). Required for normal aggregation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSSGNPFDNGNPNDGNKSPSIDELYSPSESLARDGDDNNNNNNNNNNNNNNNNNNNNSSVSEKKKSKKKVRIQEEERLTESYDDDGDDEERRAYIENEEGEEEETEDGIILQPIVRDHSTYRPKNLYGSSDDIREGDSFGAKVSKTFGKTNKKIKQKIGESNKKIETRVKHSNKAIEEGWKTIAQTTMKPVDNIREQHHRRAEQHEVAERAVWFKDKLQIQKYECLDYVTIYNKAHRNELYKNFSKLASDHEVLRWIVSLFMGIFIGVIAYFSHACVSNITKYKFKFVEAVLELDLFLAFLTYFLLNTLLATCSSLLAVYYEPTAAGSGIPEVKGYLNGTKIPHTLKMKTLWTKFLSMVLAVSSGLQAGSEGPMIHIGAIVGNGFSQAQSKEFGFKIPFLRSFRNDKDKRDFVTSGAGAGVAAAFSAPLGGTLFSLEEVSSFWSIALTWRAFFCCMVATYTMNVLQSNSGSLTGLIIFNTGIGDKESYNWFEIIPFLLIGVLGGLGGALFTWINVKVTEFRREKINKIKSLRVLEVFLIIGLSTCIQFFLPLFFSCQNTAPFIPSVGNSTLTDVTLTNGAFYNSTIINGTFYNSTIANGTIYNSKFYNSSIYNSTITNGTGVSYDPAETLKELSEFKRFNCKEGWYNPMATLIFASYEESITNLLKVNSNNVTNTERLGLWPMFLFCIFYLFFAAYTAGCAVATGTLVPMLVIGASYGRFVGLVVYHILGDKVSIDPGIYAVMGAAAFMGGVSRLTISLTVILIEITDRLKYLLPLMLTVMTAKWVADALIHPLFDLLMQMKYIPYLELDQSKEMKLMMCKHIMAKKPVYLAEKDTLGNLRVLKETRHNGFPVVNNDEEKLVKGLILRTQLLMILERISDVYIPNSEAIYSHIEYTTKLTWKLPSVNDFNFDPADYSQEIDLSDVMNLTVITVNVEFAVSEAFQLFRTMGLRHMPVVNENNKLKGIITKKDLLEKTCEQRYRELNHMKLGIDQLIHVGDE
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEPDDGHNSLNQDNGIPIVLDPNLINLRSRAASATVTTNGTTADSSEDSGSQQSVSSAPIQQNSEEHSLVSNPYETYGRMPLQKLIPLILQMRNASSFSELTEEDLLRDIEREEKGILTTGLDVEGDIEMGDADEESDLKPQEITDDDSNARLKPNNDSAIPQEEFNQMKREVLEHINLALNESSLSLEFISLLLSSVRPSVGVGSMSPFLKRSVPTASLNADKVELPPKNKTETLTLAVINRGWKLRSLEDSKALLKENYAKLQKSLEVEHAHWAMISQHISSTDVVFKMRDRQTGKRSLAVKYGYEDSGSLYKQDRGVAVLRHNMDLNKLELVPISNSKEEVHITANSVERFMRVHIYTKIEEEDDYILSGESSIDDQSLLQPCHDDISRQIARLKFFIFERELMYQLKKEAVSLMPYGVNFENENKVVLESPGERIEFEMVPLDDSALLSTHEPRRVNDKRANIILILLRMLLVVIHKKQLRRGLKPATSKHKYRADGDLLLLRPVLGRIRHRNYLQVVKRVVTECVLNIVPGSSIELLPQRSEPDTLHAREANIASLNKQIGLFDKILRMPRSELRTSLGAKGVIDLTLKSSNYCNAIIQVIYADSAGKTVFDTVFTELKELEEFLHFIVSEYVL
The following text describes a protein:
Function:
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. Could also be permeable to glycerol.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
SVAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALGHVSGAHINPAVTVACLVGCHVSFLRAAFYVAAQLLGAVAGAALLHEITPPHVRG
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKIKARDLRGKKKEELLKQLDDLKVELSQLRVAKVTGGAASKLSKIRVVRKSIARVLTVINQTQKENLRKFYKGKKYKPLDLRPKKTRAMRRRLTKHEEKLKTKKQQRKERLYPLRKYAVKA
The following text describes a protein:
Function:
Repressor of the cell division arrest function of DgcN. Prevents DgcN relocation to the midcell.
Subcellular Localization:
Periplasm.
Sequence:
MRFSHRLFLLLILLLTGAPILAQEPSDVAKNVRMMVSGIVSYTRWPALSGPPKLCIFSSSRFSTALQENAATSLPYLPVIIHTQQEAMISGCNGFYFGNESPTFQMELTEQYPSKALLLIAEQNTECIIGSAFCLIIHNNDVRFAVNLDALSRSGVKVNPDVLMLARKKNDG
The following text describes a protein:
Function:
Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism.
Domain:
The THAP-type zinc finger mediates DNA-binding but is not required for repression of gene expression.
Sequence:
MPTTCGFPNCKFRSRYRGLEDNRHFYRIPKRPLILRQRWLTAIGRTEETVVSQLRICSAHFEGGEKKEGDIPVPDPTVDKQIKIELPPKESKNSDRRRKQNIPARFPRPESPSGDSPSYSKKSRSFRDFYPSLSSTPSFDPAQSPHTPHPPVLPDPQQALNDILSMTSTRMNGPSSSRPLVALLDGRDCSVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVAALMYHSIKLEKEDLEKFKVLKVVFRIGYGIDNIDVKAATELGIAVCHAPGDYVEDVADSTLSLILDLFRRTYWHAKSYSETRKTIGADQVRENAVGSKKVRGSVLGILGCGRVGTAVGLRARAFGLHIIFYDPFVREGHDKALGFERVYTMDEFMSRSDCISLHCNLGDETRGIINADSLRQCKSGVYIVNTSHAGLINENDLAAALKNGHVKGAALDVHDSVRFDPNCLNPLVGCPNIINTPHSAWMTEASCKDLRINAAKEIRKAINGRCPQDLTHCINKEAVMRNSNPINRRTSSAHPLLNMGFPTLPNFPPMSMSPHFPYPNPLLAMGAQMGALNPFMGNGALPFNPAAALSSLAAAQAANAQRGSPANRSSRSSPSPHTNKSSVSPGNNGHVKTEPSSPAAKIEVDIAENDKHSMMTFLQRLIAPNGDSGASTADSGIEGGDKEKVQSDGDENMEDMEVIDAEKLKEELNIGQLEEPEEISVGLNNGNRINIDEQPLAT
The following text describes a protein:
Function:
Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MIGRLLRGGFMTAIYAYLYIPIIILIVNSFNSSRFGINWQGFTTKWYELLVNNDSLLQAAQHSLTMAIFSATFATLIGSLTAVALYRYRFRGKPFVSGMLFVVMMSPDIVMAISLLVLFMLLGIQLGFWSLLFSHITFSLPFVVVTVYSRLKGFDVRMLEAAKDLGASEVTILRKIILPLAMPAVAAGWLLSFTLSMDDVVVSSFVTGPGYEILPLKIYSMVKVGVSPEVNALATVLLVLSLVMVIASQLIARDKTKGR
The following text describes a protein:
Function:
Catalyzes the hydrolysis of dATP, dADP and dAMP into dA. This step is essential for Z-genome synthesis (containing aminoadenine instead of adenine). Specifically removes dATP and its precursor dADP from the nucleotide pool of the host, preventing the incorporation of A into the phage genome and favoring the integration of the Z-base into the viral genome.
Sequence:
MMTMTPRDLMRAQYVTRWQIVPTTRSQSVAQHSWAVAMLAMNLWCRRTGGQPGEAATDVELGKIAVMALWHDAPEVFTGDINTPTKIFLNASNALDELENTAGDGYLESMDGGPIRTCVKIADFLEAMYWLMEHGDGHYANNQLHGLNERFHQYLNEHAPLWRDSAVALWKELSDVNAETTTFQRVNYLKANDA
The following text describes a protein:
Function:
Involved in cell division, cell envelope biogenesis and cell shape maintenance.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MENWTNEIWVAIGIAFIVGLFIGYIIVRLTKGSVKHQAKTEAELKTVKTQLDTQKAQIEKHFAESAELFKTLINDYQKLYRHYATSSNNLLGEKDQKGLFTQQLITATDKSQNEQPRDYSEGASGLFKENKEEN
The following text describes a protein:
Function:
Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (By similarity). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAGQQFQYDDSGNTFFYFLTSFVGLIVIPATYYLWPRDQNAEQIRLKNIRKVYGRCMWYRLRLLKPQPNIIPTVKKIVLLAGWALFLFLAYKVSKTDREYQEYNPYEVLNLDPGATVAEIKKQYRLLSLKYHPDKGGDEVMFMRIAKAYAALTDEESRKNWEEFGNPDGPQATSFGIALPAWIVDQKNSILVLLVYGLAFMVILPVVVGSWWYRSIRYSGDQILIRTTQIYTYFVYKTRNMDMKRLIMVLAGASEFDPQYNKDATSRPTDNILIPQLIREIGSINLKKNEPPLTCPYSLKARVLLLSHLARMKIPETLEEDQQFMLKKCPALLQEMVNVICQLIVMARNREEREFRAPTLASLENCMKLSQMAVQGLQQFKSPLLQLPHIEEDNLRRVSNHKKYKIKTIQDLVSLKESDRHTLLHFLEDEKYEEVMAVLGSFPYVTMDIKSQVLDDEDSNNITVGSLVTVLVKLTRQTMAEVFEKEQSICAAEEQPAEDGQGETNKNRTKGGWQQKSKGPKKTAKSKKKKKPLKKKPTPVLLPQSKQQKQKQANGVVGNEAAVKEDEEEVSDKGSDSEEEETNRDSQSEKDDGSDRDSDREQDEKQNKDDEAEWQELQQSIQRKERALLETKSKITHPVYSLYFPEEKQEWWWLYIADRKEQTLISMPYHVCTLKDTEEVELKFPAPGKPGNYQYTVFLRSDSYMGLDQIKPLKLEVHEAKPVPENHPQWDTAIEGDEDQEDSEGFEDSFEEEEEEEEDDD
The following text describes a protein:
Function:
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Domain:
Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin; The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.
Sequence:
MAFNFNWSPLTADASFYKRARDLLTTALNKSPKPPIIVDDILVTEFNLGSVPPELEILEIGDLAEDRFRGIFKMTYSGDAFLTLKTRVQANPLNTYLYSKPSFTSPEPLAAASGLTIPLQITLSEIKLSAFIILVFSKQKGLTLVFRNDPLESLKVSSTFDSIQFVRDYLQRTIEGKLRNLMMDELPAIIHKLSLQLWCPEQMSKEDHEKTNEMDEQAVNPFASPPLDAVDAHGNLLDPIDISSIAVNGGAELQSLFSQKNLFRLGNLVNTQLTSSLFTPSVPEVIFRAKAGPVDKPEASSTTPLTTPSLVKSHSFHGTSTVYTFSDTSSQNNGQLPSRPSLVSLGSATTGLGLAASRNAKPYANRKKKTRVVNLRRKTDTAASSEMGDTMSDSASVQASESITMSDSIPEDPEEQPELTMSGSSRVRFGLGGERSALPQRPALRRDLFNPDEATASAEISQPQVARSTPEKETAAPVRTSENDKRSDSKRRGPRSETPSVILEQAWIMKMAGEIAKRVYDEKQRNPSFWDEREDSPPPAYEAQPTTAAS
The following text describes a protein:
Function:
Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature pro-inflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of pro-inflammatory caspases.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cytoplasm.
Domain:
When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding; The pyrin domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD.
Sequence:
MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPLDVDEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKSWPGDSKEVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIHKFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDISCKGGHSTVTDLQELLGCLYESQEEELVKEVMAQFKEISLHLNAVDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLIIDTEKHHPWAERPSSHDFMI
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. In addition to the protease activity, also mediates delipidation of PE-conjugated ATG8 proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MKGFREIDTDPLRNSAVKKSDFDNSPKNSPGSVSSEAEPSIRHSNHKKSEAIWSVIWPTTIPIFGISNSNRTESESKNSGGSVIRKKSSSGSKNYYEGWRGAVRRVMMNGVTMRRIWGFSRATTSSSKSNIWLLGVCYQVSQEGEESSSDPTQSEGFAAFVEDFSSRVLITYRKGFSPIGDSKYISDVNWGCMLRSSQMLVAQAFLVHKLGRSWRKSPHKPLDQTYVEILHLFGDAEDSPCSVHNLLQAGKAYGLAPGSWVGPYAMCRTWESLVSSTTECYIHVSAKPWYFGG
The following text describes a protein:
Function:
Methylates ribosomal protein L11.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAANSWWEIRILCHPSLEETAFWRLEKFGCLGTSTEKKAHSLLVRGYLPQEKAEILDLAALALWCEQDALLFQVPKPRFHWQLIDEEDWSISWKEHWQPTPVGDRFIIYPAWIDPPENSDRLILRLDPGVAFGTGTHATTQLCLESLEMRVEPDKHQVLADLGCGSGILGIGAVLLGAAKVYGVDNDPLTVESARHNRHLNQIHPDNLVINEGSVPELEQLIAEPVDGIICNILAEVIVDLLPQFTPLVKPHGWAILSGIMVEQSQAIADALEQNGWTVVAIWKRQEWCCFQARREEGD
The following text describes a protein:
Function:
Transcription termination factor required for plastid-specific rRNA accumulation and protein synthesis in plastids. Essential for embryogenesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MMIARCSLFPPPCFSAVRIRCFAGETSDTGILFREKLIYLQDLNVDPHKALRVNPSLRSAPISSVVSVETLLSSTGLSRPAVGRILDMFPDLLTSDPESEILPVLRFLSNEISISEQDIPKSISRCPRLLISSVDYQLRPALTFLKTLGFVGRDTITSRNTVLLVSNVERTLIPKIEYLEEGLGFTREEVAKMVVRSPALLTYSVDNNLVPKVEFFIEEMRGDVKELKRFPQYFSFSLERKIKPRHRLLKEHGILMPLSEMLKVSDGQFNHWLLELRLRSAERR
The following text describes a protein:
Function:
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Subcellular Localization:
Cytoplasm, nucleoid.
Sequence:
MIGGKFNLGSLMKNAKKIQEMMQKAQDELAKIRVTGESGAGMVKLTMTAQHEVVEMNLDDELLKESKEVIEDLIKAALNDANQKILKITQEKMMSAGSLFGGNESDNEET
The following text describes a protein:
Function:
Accessory factor for DNA replication. It plays a role in accurately duplicating the genome in vivo.
Miscellaneous:
MISCELLANEOUS: Present with 3280 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MVSVIDKLVFDFGGKTLVSLAPDNNTLCVANKNGLTKILKTNNPEEEPETLDSSKLVSSIKCYSNSHFLMTTMQGDALRYNIDSSQEELLARFALPLRDCCVIHSGKMAVFGGDDLELILLELDDETHKKHAIKIDEQVSQISYNSQMNILAVSMINGKVQIFSLTSTIPNKVHELNDYIVANSYDDTHRDKILSNMMDDIDKDNDNDLSETADPDENNVADPEFCAANRICTRVAWHPKGLHFALPCADDTVKIFSIKGYSLQKTLSTNLSSTKAHFIDLQFDPLRGTYIAAVDLNNKLTVWNWETSEIHYTREFKRKITNIAWKIQADSKTLDLVLGTWSGSIAIVQNLAESVVSNIPDQSVAESSTKHGLFVDSESDLENLEGNDDINKSDKLFSDITQEANAEDVFTQTHDGPSGLSEKRKYNFEDEEDFIDDDDGAGYISGKKPHNEHSYSRVHKTHSFPISLANTGKFRYMPFSPAGTPFGFTDRRYLTMNEVGYVSTVKNSEQYSITVSFFDVGRFREYHFEDLFGYDLCFLNEKGTLFGQSKTGQIQYRPHDSIHSNWTKIIPLQAGERITSVAATPVRVIVGTSLGYFRSFNQFGVPFAVEKTSPIVALTAQNYRVFSVHYSQFHGLSYSLSELGTSSKRYYKRECPLPMSLPNINSDMKKDANLDYYNFNPMGIKSLFFSSYGDPCIFGSDNTLLLLSKWRSPEESKWLPILDSNMEIWKMSGGKETTDIHVWPLALAYDTLNCILVKGKHIWPEFPLPLPSEMEIRMPVFVKSKLLEENKAILNKKNEIGADTEAEEGEEDKEIQIPVSMAAEEEYLRSKVLSELLTDTLENDGEMYGNENEVLAALNGAYDKALLRLFASACSDQNVEKALSLAHELKQDRALTAAVKISERAELPSLVKKINNIREARYEQQLK
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSAKLLTFLLNGGTYLAIVPPLNKQNNYKYKFYVYAMSAFISGSVIATLFFKDFYADFVLIKKAVCIVEDIFLLSLNLHILNIFGLRRREQWSALIECFKATENLVLVELNKRKVPYYLGFVIANIVHFSIAVYEYFFWTQSIGLSFIKKYFNRYLQMYLNFYCIFLLCVVTNMILLRYKGFKATLRTQTHTHLNKNSLLNLISKVEKTMYSLKKIVDLYNTMFGWTLFLIISLTTIQILNYIDFIIFYTQVEAGSVQIVLLSLAIITWVFSGALVLILLCSFVEQEVEEIVLLTYDIRLRVAGKINLEGYKMQEFTNFVNKNLPSFTAANFFHIGRSTILNMLSTVSTFIIILIQFRKQ
The following text describes a protein:
Function:
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
Subcellular Localization:
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Sequence:
MPKGDGKLVAQNKKARHDYAIEETFEAGIVLQGTEIKSVRNARVNLKDSYARIDKGEIFLHNMHISPYEQGNRYNHDPLRTRKLLLHKKQISRLIGETKESGYSIVPLKMYIKDGYAKVLIGVARGKKKYDKRQDLKQKEAKRDIERAFKERQQ