The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for the starvation-induced activation of the ACA (adenylyl cyclase) expression pathway at the growth/differentiation transition.
Subcellular Localization:
Nucleus.
Sequence:
MMGTKVPSYNNKQQSGSNAGGNVNNNNNGPNINNPNNPNNTNSLPTTSGYNSSRFSVPNLDTDNFMTNIISMGVNKVGWALYRSNSNNNNNNINNNSSSSSSSNTSNNINSNTLVNDPILLAYLKTIELGVPCLWRKTRSKKPINNSSNNSNITSSTSTDSSLKNRLKNSPSETTPPNTTNNNSNNVTKDSPPNATNKMSTSPKSLSPTISNNNNNTTAAATTTTTTTNNSSNSPTSPTNNNNNNNNNNSPSSHNVVNSPPSTSSRSPPTVASVTSNTSTIQPISPIINRQTSSHNYQQPQQPYYNHQPLQPIQEYITTYELWVFNISNTSLLDFSHLNNVESGIVNLDNIGCNNSVIVQYLFKSLYNLVEYNMVSNDFIKIGNSFIKSSHILQKQKQSRNDYNNSIISGSVGSKKRLFEDFTNLYIEDDCLLSCSFSFFIYNKSIHLHFNVDKKRLKPLQELMKSEYINSPLFTSPNAFIAFFNNNNKNNINNNSNNIINNNNNSNINNNINNNNNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTINNNSNNISSNNDNNNTPSQMVPSIDGHDSSSSSSTPSQVTMQTTPTQEFSNNNNNNISINTTTVPITATTATATNKITTAATTTTTINNNNNKIQTESFGSTRNKKLNDEEEINFSLSSQQWKQLFNIGLANKAIIPKQQTPQQQEQQQIIGTIFKKNQLEVPKSIKTIITRGNSLPLINTFFPIELLFKFFPPISDISQYTYHEKLKEFGLEIFDKSPYALLEKGLNLFINNNNINIENNNNTSNEINNTGTQIPTKYKYVDFWSLPLFHSKESLIYGNDHFNATYCVKAVPSPSSPLTQHPSSPHSPFNNVNSPKSPQHPPSPKTPMISDDDQSLTANNEKKRHGKSQKKGRSSKRKKDDNSNNNNNNNTTTTSTITATTTTTTPTAATTGNDNFLAPQSKPPPSNIQETSQPQSLTTVQPQPPPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVVSSFSGQGLNSSMDLFGSDAFDTFKNKEDDLMHLSDTDIDLDLWTSHYVPPNQPTQNGSQKNNQRPLPVEDPFQVFQVPNKPATTTTTTTTTTTPTPNPTTTTTQPQTQPQQQSQQQQQPQQTNPILPTNSNLITNQKPQQYQPPLQDPFQSIDSQQPKSIQSPTLTNQPIGMVSPTLTNQPLQQYQPPPPPTQQPQQAHLKPPPPKQPSAKKNSKDGINSDENKPFLDGQFLCPVPYKAPSLSQNQLPILHLPHNTEQSPSNDDLSNPNHLHHGTPTSAISGVGGSSSSSGNNMIGSGGIVGSGGGNTNVSGSGGGMVSDPSKLTYSSEHHDPHHHHHHHHHHHPQNSQNLRNSYGNSNGVGGSQDESIDGLTTVYRNLTLSRPLGDNKNKNNAPYYCAPSYKPLDEHSLPHQLKFEYSYTPLVKPQNQLNQTKYSPFSNSHHNHHHNTTTNNNNNHNNNNNNNHPNNHHQNNNHHHLNITSSLFQPSNIQNVNSLPNIGSQKIMSISPPITPPMKGGHMIGTDINKNNNKKNNDEDENLEILSTIKQKDVNGLDSNLSSSALLSFFDQAINIKTTPPRSPVLSGYSGGGSNMNNGINGNSGFIGNGNSGFNTISSYQQNNISIEESLDLAFTIQQMTITNYDSTFGFSIDNSPLIKQSIDYYLENWLKIYTETGKVFNHHSLQFLTEESISDALDTVIDPLTTNTILETTVKTLFTFSNEIFKKIFPLSSFPLSIKEFCHLPSITLNNINNNIDLLNSQTYQNTNNSSSGGGIESQQYFSGSSGLNNSNDRNSMIPMDNSDDTSDLMSMDDHNSKNLITGTSLISTTASGAGAAITTNLINQNYEEFEWLPIPKIIVGYKEDWLEVPISTIKFWDKAQLEPYSPKKNITYFVLCPDTTAMRMHVPAFFSDLSCIYETNHLGNHVTQQQSQVQQAAAAAVAASQPTQQSSQHQSQQQQQQAAQQAAAAAAAAAAAQKNSSPFYNGIYYIPSAANTEFNPQTFINSYLLTCIQFGDYLKELSTKYSENNCMVLYIVNPFSDLSQISLSNQNQNQNQNSNSNESQQQQQQQSNNKQKQTQTNEDINHIRNSYLFMSSCFQTIVRDITCNQSLSITIQTIPIEQILFDDHPSIPVSKELAFSVFNKCRRISTISPMNFSINMNNINNMIGNNNSNSNNSSGWYYQLFNKIYEPLFILSNESSSSSSSTISTSTSASTSTSTSNTTTKNQQQQSQSQQSQQQSQQPKQLSTPTTPTTNSVSNSPSLQPQPLQTPNQLQPHQQEQKQQQQIPIIHFSYMLSDDNKWISCTIVDEQGELLENKLIPLAYSQIIGDYIWKDSFQNAWFFLTEIIGLSLSGQPCQVVIGKFGIISMQEYNDWKTTIIHFEDNLEVIKQHQQQSQSQNYSSTIDQIYKIENVIFLNLTLNNNIKSFLTEYLNDSKLSNSNNIKSVSPLSGQSFAIYPESPIMYTYNFPMNDNNDDYNSILNNNNNNILPPLSTSFVITSPSNLSGSVLTPTTTNSNVINNNQSKKEWPFTYMLSIVGIQSLQHQQQQQQQQQQQQQQQHPNIINHQELIRSITRSYHRLSYLNISPRYPDRLSILPIHFSISKRMSRTVCLISPLNPIPPPILFNRCPKLTPNSKQSPSPINSPHLNSNNT