lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Alpha/beta hydrolase; part of the gene cluster that mediates the biosynthesis of novofumigatonin, a heavily oxygenated meroterpenoid containing a unique orthoester moiety. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase nvfA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations. DMOA is then converted to farnesyl-DMOA by the farnesyltransferase nvfB. Epoxydation by FAD-dependent monooxygenase nvfK, followed by a protonation-initiated cyclization catalyzed by the terpene cyclase nvfL leads to the production of asnavolin H. The short chain dehydrogenase nvfC then as a 3-OH dehydrogenase of asnovolin H to yield chemesin D. There are two branches to synthesize asnovolin A from chemesin D. In one branch, chemesin D undergoes Baeyer-Villiger oxidation by nvfH, methylation by nvfJ, and enoyl reduction by the nvfM D enoylreductase that reduces the double bond between C-5'and C-6', to form respectively asnovolin I, asnovolin K, and asnovolin A. In the other branch, the methylation precedes the Baeyer-Villiger oxidation and the enoyl reduction to yield asnovolin A via the asnovolin J intermediate. Asnovolin A is further converted to fumigatonoid A by the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfI that catalyzes an endoperoxidation reaction. The alpha/beta hydrolase nvfD then acts as an epimerase that converts fumigatonoid A to its C-5' epimer, which then undergoes spontaneous or nvfD-catalyzed lactonization. The following step utilizes the ketoreductase nvfG to produce fumigatonoid B. The dioxygenase nvfE further converts fumigatonoid B into fumigatonoid C. Finally the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfF catalyzes two rounds of oxidation to transform fumigatonoid C into the end product, novofumigatonin A.
Sequence:
MLKPAIIIVPGALHRPEHYQGIVSRLHKLQYEAVAVSMPSLSSSPPQPTWTEDVEAIRKAIFKFSESGQDVVLVGHSYSGILISEASKGLSRKDLPHGEGAVVRLIYMCAIAVPVGESLTGQLEPRTPQEVEAFREEGSISLLDADKVRDVLYNKCEPKVADWAISLLGKQPVTTMSTPATHAAWLEIPSTYLICEDDLAVPECVQLRMAKQGNGAFDIVRCQEGHAPCLSNPDLVVRMIRNAAGEAIEI
The following text describes a protein:
Function:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Miscellaneous:
MISCELLANEOUS: The T6 pseudogene located upstream of SRY on chromosome Y is derived from the transcript of this gene.
Subcellular Localization:
Nucleus.
Sequence:
MESGDEAAIERHRVHLRSATLRDAVPATLHLLPCEVAVDGPAPVGRFFTPAIRQGPEGLEVSFRGRCLRGEEVAVPPGLVGYVMVTEEKKVSMGKPDPLRDSGTDDQEEEPLERDFDRFIGATANFSRFTLWGLETIPGPDAKVRGALTWPSLAAAIHAQVPED
The following text describes a protein:
Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
Sequence:
MKVKFAVLGDAFVDVVAGTLAPEQLPQWGSDVECSRPIQLQPGGSALNTATHLANLSSCNPQHELHVALHTAVGNDSFANVLKAHLAERNVALSSPTLGSVPTGVCIVLSGANDRSFITHYGAARKFSIEHVDEKMVLSADHLHIGGFYSCASLRVTLKSLLEKARENGITTSLDTNYDSTEKWDDLDELFPLIDVFLPNEVEAMKISRTESVAAAMAYFADRIDGVTVIKIGAGGAMGHCSKTQQQWKQGSFPTSVVDVTGAGDSFNSGFLSAWKTNGGDVGDALRWGCGTASRAVAALGACSFPLTYDDVQNVIM
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MPHAEPELESAAARVLRPKFMLAILAYKYAASRSYHETRSRNPKRDRSKMATKMVHLRSSDGEEFEVKEEAIAAASGTIKAELEKKDGAAAGVILVPDVTGRILSRVLEYVNRHFSDPAAAADRFDDYIPIADDPLKALDDALVRVDQDTLFDLVHAADCLAVEGLMDLACKELAGQMRGKTIDEIRDKFHIVNDYTEQEEEDVRRDNAWAFE
The following text describes a protein:
Function:
Probable hormone (Probable). Promotes chemotaxis in myeloid cells.
Subcellular Localization:
Secreted.
Sequence:
MLTFNKMKTTTCSLLICISLLQLMVPVNTEGTLESIVEKKVKELLANRDDCPSTVTKTFSCTSITASGRLASCPSGMTVTGCACGYGCGSWDIRDGNTCHCQCSTMDWATARCCQLA
The following text describes a protein:
Function:
Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: Due to intron retention; MISCELLANEOUS: [Isoform 4]: Due to intron retention; MISCELLANEOUS: [Isoform 5]: Due to intron retention; MISCELLANEOUS: [Isoform 6]: Due to intron retention.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, perinuclear region. Cell membrane, sarcolemma. Sarcoplasmic reticulum. Note=Localizes to centrioles and deuterosome. Found primarily in the perinuclear region as well as along the sarcolemmal membrane and in reticular pattern within the sarcoplasm.
Sequence:
MEHAATTGPRPGPPSRRVENVVLRAKDWLPGAPGGTAVWATSLEAEVPPDLALNKEQQLQISKELVDIQITTHHLHEQHEAEIFQLKSEILRLESRVLELELRGDGTSQGCAVPVESDPRHPRAAAQELRHKAQVPGHSDDHRFQVQPKNTMNPENEQHRLGSGLQGEVKWALEHQEARQQALVTRVATLGRQLQGAREEARAAGQRLATQAVVLCSCQGQLRQAEAENARLQLQLKKLKDEYVLRLQHCAWQAVEHADGAGQAPATTALRTFLEATLEDIRAAHRSREQQLARAARSYHKRLVDLSRRHEELLVAYRAPGNPQAIFDIASLDLEPLPVPLVTDFSHREDQHGGPGALLSSPKKRPGGASQGGTSEPQGLDAASWAQIHQKLRDFSRSTQSWNGSGHSCWSGPRWLKSNFLSYRSTWTSTWAGTSTKS
The following text describes a protein:
Function:
May function as an adapter protein.
Sequence:
MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYREQKDLDFEDPYEDADSRLEPDSSGGPGDSKGPGDAKYDSPKHRLIKVEAVDIARAKVLLGSPGEESKVDTEYSDPFDAQPHPPPPDDGYMEPYDAQRVMSELPCRRVQLYDTPYEEQDQELGDGPPSGQKPRQSRLPQEDERPADEYDQPWEWKKDHISKAFAVQFDSPDWERTSGSAKELRRPPPRSPQPAERVDPTLPLEKQPWFHGLLSRADAENLLSLCKEGSYLVRLSESSPQDCSLSLRSSQGFLHLKFARTRENQFVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVSQTP
The following text describes a protein:
Function:
Essential component of the deoxycytidine triphosphate (dCTP) pathway for de novo synthesis of thymidylate. Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates (dAMP, dGMP, dTMP, dUMP, dIMP and dCMP) and does not dephosphorylate 5'-ribonucleotides or ribonucleoside 3'-monophosphates.
Subcellular Localization:
Cytoplasm.
Sequence:
MKQSHFFAHLSRLKLINRWPLMRNVRTENVSEHSLQVAMVAHALAAIKNRKFGGNVNAERIALLAMYHDASEVLTGDLPTPVKYFNSQIAQEYKAIEKIAQQKLVDMVPEELRDIFAPLIDEHAYSDEEKSLVKQADALCAYLKCLEELAAGNNEFLLAKTRLEATLEARRSQEMDYFMEIFVPSFHLSLDEISQDSPL
The following text describes a protein:
Function:
Probable methyltransferase.
Sequence:
MDGVIESPSNNTIKISPSTSDSSTTTPIITTPPTQSTATVTTKAAATTTTTEASTTPPPPQPTPTPTQSTATVTKEVETTTETIPPIVTKGKIKKSKKSIKKPTIVKRPTTPIDYKQWHTEWPIHVYSHPINGRYLVATKDLDEQTVILRDLPYTWAVDHATCDSVCQHCFLEVPLNQQILPTDFYMCEGCQRVGYCSANCRCIDYSQHRFECQIFKELDTEEYSPFLMSEIKLLVRTLSRKWLEDSITQTAGIDINDETIKKQNTYNQYKNPQSLIPQDNGLRYNDYAELVSNVENYNESLKESLSYWICKYVVKLSAKLGKIEDEFDLLNILLRNRCNAFYIQGRPRDGSSGESRGCGVYVRNSFFNHSCDPNVNYWVVNNTLEVECTLLKNVKEGDELTISYIDTTSPLNKRREKLLEGYLFNCLCTKCVADESLPLDQTGTLEKDDDDNDDEKEKMDEDDDEKDDDINNKNDKKSKYKSDGSTDDEEDEDNNNNKNNNKNKNNNSNNQDHQNNDKSN
The following text describes a protein:
Function:
Assembly of polyisoprenoid side chains. The polyprenyl synthase of coenzyme Q biosynthesis catalyzes the formation from isopentenyl diphosphate of all trans-polyprenyl pyrophosphates generally ranging in length of between 6 and 10 isoprene units depending on the species.
Miscellaneous:
MISCELLANEOUS: Present with 1560 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MFQRSGAAHHIKLISSRRCRFKSSFAVALNAASKLVTPKILWNNPISLVSKEMNTLAKNIVALIGSGHPVLNKVTSYYFETEGKKVRPLLVLLLSRALSEIPMTERNHLKIDKSDVPEDPIYSKPSQNQLFQRPASSISPLHILHGIKPLNPLTKGPEPLPEETFDKQRGILPKQRRLAEIVEMIHTASLLHDDVIDHSDTRRGRPSGNAAFTNKMAVLAGDFLLGRATVSISRLHNPEVVELMSNSIANLVEGEFMQLKNTSIDADIDTIENGHKLLPVPSKKLEVKEHDFRVPSRQQGLQLSHDQIIETAFEYYIHKTYLKTAALISKSCRCAAILSGASPAVIDECYDFGRNLGICFQLVDDMLDFTVSGKDLGKPSGADLKLGIATAPVLFAWKEDPSLGPLISRNFSERGDVEKTIDSVRLHNGIAKTKILAEEYRDKALQNLRDSLPESDARSALEFLTNSILTRRK
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB33B acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. Participates in autophagosome formation by recruiting the ATG12-ATG5-ATG16L1 complex to phagophores, probably in a nucleotide-independent manner.
Subcellular Localization:
Golgi apparatus membrane; Lipid-anchor. Golgi apparatus, cis-Golgi network. Preautophagosomal structure membrane. Note=Under starvation conditions punctate RAB33B-positive structures are often observed in the cytoplasm. Under starved conditions RAB33B translocates from the Golgi to phagophores; this translocation is driven by interaction with ATG16L1.
Domain:
Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins. Although most effectors only bind GTP-bound Rab, ATG16L1 effector binds both GTP- and GDP-bound RAB33B.
Sequence:
MAEEMESSLEASFSSSGAVSGASGFLPPARSRIFKIIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVDFRERAVEIDGERIKIQLWDTAGQERFRKSMVQHYYRNVHAVVFVYDMTNMASFHSLPSWIEECKQHLLASDIPRILVGNKCDLRSAIQVPTDLAQKFADTHSMPLFETSAKNPNDNDHVEAIFMTLAHKLKSHKPLMLSQPPDNGIILKPEPKPAMTCWC
The following text describes a protein:
Function:
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
Subcellular Localization:
Cytoplasm.
Sequence:
MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPSPKCPQPCPPQQCQQKYPPVTPSPPCQPKCPPKSK
The following text describes a protein:
Function:
Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
Subcellular Localization:
Secreted.
Sequence:
MIHRIWHYFLYLYGLFLDSLSVCDSNNRLSTSGINKTQFPSQYLGQWYFVAAAATPGTRALETFTAMDNAEFSVRQCREEQNLDFRAAIRVKDGSCVPRKWIYLLPEGSTELRTEGHPDRLTQLFPFRCPHCIILKETDNSYARLLLYSRLPQLEEEFMEEFKNKSNCEGYTDILKIPQQQDYCQIED
The following text describes a protein:
Function:
Catalyses the transfer of galactose onto proteins or lipids.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MWRLRAKWRCVVCLQIIGSFCLGAYVHFLATTKQLREETTTPTTVHRGLGSAENHLFKTVEGSGPPTQNNKPTTSTAGRLFQKIAYVEKKSVPPVTGMLEKDEKWRRNIRSREELGVGSSHQSDFSIKKISNDEVKRPSRKQLGLTNSLHIGRHFTVDLESIDVPFGGKWKPSTIDSSIISEKIAVLVPYRDREEHLKTFLSYIHPFLQRQGRYYGIYVIEQHGDEPLFCKGLLFNIGFNAALEDDDYDCFIFHDVDLIPEEDRNLYTCKDSPRHLSVAIDKFNYTLPYEQLFGGVTALKTSHYRQLNGYSNLFCGWGGEDDDMFKRLYRHKLKVSRPETDIARYKMLRHRQTPLNPARYALLKTSIKRASEDGLSSLETMGYQMTSTSRQRFFSHILVNIADRNARKVARHLPRLRRLRQL
The following text describes a protein:
Function:
Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Also binds other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGEQSGGCGGENCSLMPDPPTNCSHPDCLWEEPVFGWVELVMKTVKLSVPVVVTIIYVPLMLFGLLGNILTILVVWLRPHMRSSTYLYLSSMAISDLLILLLLPLDLYKLWRPRPWPLGDLACKLTMFLSECCTFCTILHITFLSLERYVAVCWPITAKTLVTRRRTRAIIGCLWLGAAVSAAPVLLMVGVEDIGGDEVGFNQWREECRCTQYAISSGLLSAMMILSNLYFLVPLSILGLVYSLIGRTLWLRPKSSRKEQGHRNTVKMLGVIVLAFVLCWLPFHVGRTIFSLSLGSVGDSPVRWPHYFNLVSSVLFYLSAAINPLLYNLMSARYRLAVRSLFAYRSFRESKAAAPCWTGEATQ
The following text describes a protein:
Function:
P2X receptors are ligand-gated ion channels that play a role in intracellular calcium signaling. ATP does not evoke inward currents in p2xD. Not essential for osmoregulation.
Subcellular Localization:
Contractile vacuole membrane. Note=Ligand binding domain within the lumen of the vacuole.
Sequence:
MDWDNIFSYNTAKIVTIKDRRLGGLHIIFMVLIIVYIVIYSTIYKKGYLLTETPVGSIRASLLAPNEFKDDSNFKYCDDNLIEYNFTKLECDYYDEAFVSFPVGDDVSFAVTTRVKTLDQVLNCSSKNPKCKYTTVSTRNVYVSDIEDFTILIDHTMFAPSSLIQYNSKQLKGYILDNDNNEIQINETINTVGIPGKPDILTIGKLLQLANIDLDGASSVNSTNSVRYDGVVALVFITYSNTFSYNTNNFKYVYSIQKVEDTEYGVPEAVILDNVSSRMYYNRHGIRLIFIQNGEIGSFNFQALLLTFVSGLGLLAISTVLVDQLAIRFLPERKTYSSHKFQITHGFSESRNKLRISQNEKDPLLLVETTKNNENNNNNDDYNDDDNEIFDDNNNGYQNIQNNNIIL
The following text describes a protein:
Function:
May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MPTDMEHTGHYLHLAFLMTTVFSLSPGTKANYTRLWANSTSSWDSVIQNKTGRNQNENINTNPITPEVDYKGNSTNMPETSHIVALTSKSEQELYIPSVVSNSPSTVQSIENTSKSHGEIFKKDVCAENNNNMAMLICLIIIAVLFLICTFLFLSTVVLANKVSSLRRSKQVGKRQPRSNGDFLASGLWPAESDTWKRTKQLTGPNLVMQSTGVLTATRERKDEEGTEKLTNKQIG
The following text describes a protein:
Function:
Catalyzes the transaldolization of either fructose-1-P or fructose-1,6-bisphosphate with methylglyoxal to produce 6-deoxy-5-ketofructose-1-phosphate (DKFP). Also catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P or GAP) to produce fructose 1,6-bisphosphate (FBP).
Sequence:
MGIFMIKRLKKRDVKVPLTVPEDRKEEYIKNYLELTKRTGNVMLFAGDQKIEHLNDDFFGEGIAKDDASPEHLFNIASKGKICGFATQLGLIARYGMDYKKIPYIVKINSKTHLVKTRDPISRALVHVKDVVDLKENSGLKILGVGYTIYPGSEYEHIMFEEASRVILEAHKHGLIAIIWSYPRGKNVKDEKDPHLIAGAAGVAACLGADFVKVNYPKCDNPAERFKEAVLAAGRTGVLCAGGKSIEPEKFLKQIWEQINISGARGNATGRNIHQKPLDAAIRMCNAIYAITIEGKSLEEALKIYYGDRK
The following text describes a protein:
Function:
Controls photoperiodic flowering response. Component of the circadian clock. Expression of several members of the ARR-like family is controlled by circadian rhythm. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock. Positive regulator of CCA1 and LHY expression.
Miscellaneous:
MISCELLANEOUS: Subject of targeted degradation by the 26S proteasome. ZEITLUPE (ADO1/ZTL) is the F-box protein that associates with the SCF (for Skp/Cullin/F-box) E3 ubiquitin ligase that is responsible for marking APRR1/TOC1 for turnover. CUL1 is the functional cullin for the SCF(ZTL) complex. APRR3 binding competitively inhibits the ADO1/ZTL interaction.
Subcellular Localization:
Nucleus.
Domain:
The N-terminus (1-243) is required for interactions with ADO1/ZTL and APRR3.
Sequence:
MDLNGECKGGDGFIDRSRVRILLCDNDSTSLGEVFTLLSECSYQVTAVKSARQVIDALNAEGPDIDIILAEIDLPMAKGMKMLRYITRDKDLRRIPVIMMSRQDEVPVVVKCLKLGAADYLVKPLRTNELLNLWTHMWRRRRMLGLAEKNMLSYDFDLVGSDQSDPNTNSTNLFSDDTDDRSLRSTNPQRGNLSHQENEWSVATAPVHARDGGLGADGTATSSLAVTAIEPPLDHLAGSHHEPMKRNSNPAQFSSAPKKSRLKIGESSAFFTYVKSTVLRTNGQDPPLVDGNGSLHLHRGLAEKFQVVASEGINNTKQARRATPKSTVLRTNGQDPPLVNGNGSHHLHRGAAEKFQVVASEGINNTKQAHRSRGTEQYHSQGETLQNGASYPHSLERSRTLPTSMESHGRNYQEGNMNIPQVAMNRSKDSSQVDGSGFSAPNAYPYYMHGVMNQVMMQSAAMMPQYGHQIPHCQPNHPNGMTGYPYYHHPMNTSLQHSQMSLQNGQMSMVHHSWSPAGNPPSNEVRVNKLDRREEALLKFRRKRNQRCFDKKIRYVNRKRLAERRPRVKGQFVRKMNGVNVDLNGQPDSADYDDEEEEEEEEEEENRDSSPQDDALGT
The following text describes a protein:
Function:
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Sequence:
MVVGQRERKRRCIRGEPLMNDTTWVLDGGRLIDPANGIDRIARLVLHEGKVHSIDTPDGDVPPDAGRLDVTGKIVAPGLVDLATELREPGSEEDETIQTGSNAALAGGYTTVLCCSSTKPLMDSAASVQLVRQIAQRVDGVRVLPIACLSKGRQAEQMAELGILAAAGAAGFSDTPRPMPNDALLKRALDYCRMFDLPIFDRPEVPELADGGVMHDGQIGLILGLKGLPTEAEDLAVARDVRLAEATKGRLHVGPVSTMGSIDMIGRVKSRGIHISASVCPHNLFGSDELLRSYDSRYKVHPPMRSPSHVEALRNAVAEGVIDAIESGHMPRAQEKKANDLDLAPFGASALETTLAAIATDLVETKILPWSRAIECLSTAPARIAGVKGGTLSVGANADVTVIDPLNAWSVEAKEFRSRCHSSPMTGRTLTARVTHTLVGGRLKFELHPTVASAAS
The following text describes a protein:
Function:
Negative regulator of the type III secretion system regulon. Acts by disrupting transcriptional activator ExsA self-association and DNA-binding activity in absence of inducing signals. Upon host cell contact, this interaction is disrupted by the anti-antiactivator protein ExsC leading to ExsA activation.
Sequence:
MEQEDDKQYSREAVFAGRRVSVVGSDARSRGRVPGYASSSLYRESGIISARQLALLQRMLPRLRLEQLFRCEWLQQRLARGLALGREEVRQILLCAAQDDDGWCSELGDRVNLAVPQSMIDWVLLPVYGWWESLLDQAIPGWRLSLVELETQSRQLRVKSEFWSRVAELEPEQAREELARVAKCQARTQEQVAELAGKLETASALAKSAWPNWQRGMATLLASGGLAGFEPIPEVLECLWQPLCRLDDDVGAADAVQAWLHERNLCQAQDHFYWQS
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLSSQQYLPSLFVRTFVEKAAESAKQATEKAVANDKKPEEKPKPTIQELEAQIKDIRNRNLFLLAEVENARRRFARLEVEMETYAVSKLAKDLLPVADNMGRIINSGAKQNVKDVIEAVKLVDAEFHNIFKRFKIEKIVSKGQKFDPQYHDAIQMIDTRGSAPSGTIIDCTTEGYKIDKRLLRAAKVIVAK
The following text describes a protein:
Function:
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MDPDRQADIAALDCTLTTVERVLDVEGLRSRIEKLEHEASDPHLWDDQTRAQRVTSELSHTQGELRRVEELRRRLDDLPVLYELAAEEAGAAAADAVAEADAELKSLRADIEATEVRTLLSGEYDEREALVTIRSGAGGVDAADWAEMLMRMYIRWAEQHKYPVEVFDTSYAEEAGIKSATFAVHAPFAYGTLSVEQGTHRLVRISPFDNQSRRQTSFAEVEVLPVVETTDHIDIPEGDVRVDVYRSSGPGGQSVNTTDSAVRLTHIPSGIVVTCQNEKSQLQNKIAAMRVLQAKLLERKRLEERAELDALKADGGSSWGNQMRSYVLHPYQMVKDLRTEYEVGNPAAVLDGDLDGFLEAGIRWRNRRNDD
The following text describes a protein:
Function:
Involved in microtubule stability and kinetochore function. May be involved in protein N-terminus acetylation and/or proteasome biogenesis.
Miscellaneous:
MISCELLANEOUS: Present with 6490 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MDFKASGTKFKKTGKKVVPAKAFEEIVQTNRDVLKKSAFLSDLLENLQPHLNNIKKIRCVAIGNFKEDFPATYQFALLLEITDYIKSEDERDVVVSLYDPIFTKEEIQYLKSLGSKWLIEEEFSENDAIDYESVLYFLPHAPLDLTENILSSQRPHLWLANNMISHTDRYTKAKLCENYPNLSKLVHYLQTNAPPEVKKAHDVDGFATFIPKRKRKNRNNSSKLKVTPSDIDYDSIAPKFKSCQILTDFDEGKYLKEKPWINSFSDLTLHAIEY
The following text describes a protein:
Function:
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRAALSVFLKDLRLEGRSKDVLSTTLFFAGLVVLIMGFAFGPDTAKMRDAAAGVLWCALAFASVLAANRAWAGEQESGALESLLLYPVAHEWLYLGKAAANALLMLILGVVTAALTAIFFDVHFASLGLLALTLALGVLGLSLVTTFYSAITVNLRAKEALLPVLSFPIIIPVMIGAVKSTVLLSGGFNPDDYWAWTRLLLGFDVVTLLVATFAFPHAVES
The following text describes a protein:
Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Sequence:
MSHYGSYYGGLGYSCGGFGGLGYGYGCGCGSFCRRGSGCGYGGYGYGSGFGSYGYGSGFGGYGYGSGFGGYGYGCCRPSYNGGYGFSGFY
The following text describes a protein:
Function:
Small polypeptide acting as a regulatory molecule which coordinates cellular responses required for differentiation, growth and development, probably by restricting polar cell proliferation in lateral organs (e.g. leaves and petioles).
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MEDERWKLSSSKGRSKSGRSCSSSSNYYYHSSDFNSSNATTLSRSYSASVTASRHATTAWSAAGAGGGGASSSSSSQHQHQQQQQQSNNSQRLSKKCVEAVKEHRARFYIVRRCVSMLVCWRDY
The following text describes a protein:
Function:
Probable L,D-transpeptidase that may perform as-yet-unknown cross-linking reactions in M.tuberculosis. Is not able to generate 3->3 cross-links in peptidoglycan, using tetrapeptide stems as acyl donor substrates. May function in the anchoring of proteins to peptidoglycan.
Sequence:
MRAVFGCAIAVVGIAGSVVAGPADIHLVAAKQSYGFAVASVLPTRGQVVGVAHPVVVTFSAPITNPANRHAAERAVEVKSTPAMTGKFEWLDNDVVQWVPDRFWPAHSTVELSVGSLSSDFKTGPAVVGVASISQHTFTVSIDGVEEGPPPPLPAPHHRVHFGEDGVMPASMGRPEYPTPVGSYTVLSKERSVIMDSSSVGIPVDDPDGYRLSVDYAVRITSRGLYVHSAPWALPALGLENVSHGCISLSREDAEWYYNAVDIGDPVIVQE
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Sequence:
MGDWSFLGEFLEEVHKHSTVIGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPGCQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKQKLRDAEKAKEAHRTGAYEYPVAEKAELSCWKEVDGKIVLQGTLLNTYVCTILIRTTMEVAFIVGQYLLYGIFLDTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMMAVAGLSLFLSLAELYHLGWKKIRQRFGKSRQGVDKHQLPGPPTSLVQSLTPPPDFNQCLKNSSGEKFFSDFSNNMGSRKNPDALATGEVPNQEQIPGEGFIHMHYSQKPEYASGASAGHRLPQGYHSDKRRLSKASSKARSDDLSV
The following text describes a protein:
Function:
Plays a role in axonemal structure organization and motility. May be involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility.
Subcellular Localization:
Cytoplasm. Cell projection, cilium. Dynein axonemal particle. Note=Localizes mainly to the cytoplasm. Present in the cell bodies of Ch neurons. Present at low level in the cilium.
Sequence:
MVNFVHPEEMYLFVESIRPFEVREVGSPKWLEVHEMILGLSQQAALELSQNREEEVKEFLISRDKLRVLIHEAYCVTLWKTRVLPHLLEIDPNPQATFLIYTVLYHEAALVALLDVCLYHPSGCETLQESVLDLIDYCAQAISQVIGLVSMGYHENETKLDVDEAVLTELERQKRDFIYKIGLRCISVLNYIADNVTLFHLSAARRLLVTHDIPWLMADVLSFRPWQRKTSKGIQKFIDEKWTNVDDVTKIVKPEAQAWFCVRQLLLNPQIMENYAFNEARCKQLHKLLGLMHEPLLDQLPPLIELKVFLSRLTLSGNTAKTQPLLLEDIPQIQEELLKDVEENGGFYQIAQDQDSVFLSKNKENICALATRLSKAYGTDLLCELEQNMDDLKMGEAKDAGAGGDGDTDHTCATCQAKAKKKCACCKKVHYCSRDCQLKDWPQHKLVCLKT
The following text describes a protein:
Function:
Regulatory component of the TFIIK complex (KIN28-CCL1 dimer) which is the protein kinase component of transcription factor IIH (TFIIH) and phosphorylates the C-terminal domain of RNA polymerase II during transition from transcription to elongation after preinitiation complex (PIC) formation, thereby positively regulating transcription. TFIIH (or factor B) is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has DNA-dependent ATPase activity and is essential for polymerase II transcription in vitro.
Miscellaneous:
MISCELLANEOUS: Present with 8700 molecules/cell in log phase SD medium.
Sequence:
MTDIQLNGKSTLDTPSATMSAKEKEAKLKSADENNKPPNYKRISDDDLYRHSSQYRMWSYTKDQLQEKRVDTNARAIAYIEENLLKFREAHNLTEEEIKVLEAKAIPLTMEEELDLVNFYAKKVQVIAQHLNLPTEVVATAISFFRRFFLENSVMQIDPKSIVHTTIFLACKSENYFISVDSFAQKAKSTRDSVLKFEFKLLESLKFSLLNHHPYKPLHGFFLDIQNVLYGKVDLNYMGQIYDRCKKRITAALLTDVVYFYTPPQITLATLLIEDEALVTRYLETKFPSREGSQESVPGNEKEEPQNDASTTEKNKEKSTESEEYSIDSAKLLTIIRECKSIIEDCKPPSTEEAKKIAAKNYYCQNPSTLIQKLKRKLNGEDTSSTVEKKQKT
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.
Sequence:
MIKISLNSNKRAWMWWFQGVIFLNPKIVSWLLKAYRMSDNLLHKDIQALIARLKRQDLSLGMLEKSLSRLIHDEINLEYLKACGLNFIETSENLITLKNLKTPLKDEVFSFIDLETTGSCPIKHEILEIGAVQVKGGEIINRFETLVKVKSVPDYIAELTGITYEDTLNAPSAHEALQELRLFLGNSVFVAHNANFDYNFLGRYFVEKLHCPLLNLKLCTLDLSKRAILSMRYSLSFLKELLGFGIEVSHRAYADALASYKLFEICLLNLPSYIKTTMDLIDFSKCANTLIKRPPKARYQEIPSPFSLFEKTKGLFNHKSNQLNESCLMGFMGTEILASLFDTFECCLVF