lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for vacuolar assembly and vacuolar traffic.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network. Late endosome.
Sequence:
MDKNSDESVKAQRHYMSSADESGGDEGDDEAEVGKGERGRDDAEEEEEEEEEEEPKLKYQRLWGSLPEILAKENAATCLGVAEKMLALGTQNGGVHILDFSGHEVKCFPSHTAAVNDVSFDLAGEYVASCSDDGTVVVNGLYSEERERHNYYRPIKTVAIDPEYSTKKDRQFVAGGLAGTLVLHTKGWLGPKDTALHSGEGPIHAVRWRTSLVAWANDLGVKLYDMATGQRISYIDMPRGGISAGLLRPHLVWQDDALLVIGWASTIKLAAIRTKSPNPPETPKPPSNGSVLAPAAAASTLMAGLNAMDFLGAAKTVGLGLPGPAKYVEILASIQADYLISGIAPYGKDLVVLAYIHDQPEGTATSAPPHASGQRPEVRILTRENEELTSDALSVNGFQQYQAKDYRLIHAPFMGSSEKGGQWSAGDEPLYYIVSPKDVVQAKPRDADDHVAWLVQHGRHEKALEAVEKGGARQEVLEEVGARYLDHLVLERQYGKAAQLCPKLLKGNAAAWERWVFHFASLRQLPALAPYIPTANPQLRETVYEVVLNAFLAAPSEHERFLDLVRTWPPSLYTVTTMIAAVQQRLVAFPHSAALQAALAELYLHNHQWEEALGLYLQLRRTDVFDFIERHKLQAACRDKALPLLKLDAPRAVTMLVQHRADIPPSDVVSQIQHEMRRQKRAGLAAPSGESSPGGSQAGPKGGRSRRDLRKLLHLYLHGLFEVDMTAGKEYHGMQVELYADYEPRFLLPFLRSSSFYPLEKAYETCKARGLTREVVFILGRMGNAREALGLIIEELHDMEQAIEFVSSQHDDELWEELISHSLHDPGMVGALLEHTVGNIDPLGLINRVPRGMAIPRLRDRLARIISDYRTETSLREGCNNILQSDCVALLIKFYNEARHAVRVGDPDPATPVAPEPPATTGASSLLNLPGFFPPPTVSSDELDRLPLLPSDEGSEVFGAFSFDAFMGTAKPAPVQTKDASKKKVGGNKPGRCSICLEPISVKDGDVVVFFCWHAYHLSCLSESEKRGKAASEEGLGKDGDEGLRCVLCTTAAAVKKNAHLLRTTTGSIDRSQTRSSVGWGQSASA
The following text describes a protein:
Function:
Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA.
Subcellular Localization:
Cytoplasm.
Domain:
Contains an N-terminal domain that binds arabinose and mediates dimerization, an inter-domain linker region, and a C-terminal domain that binds DNA. Arabinose is bound within a beta barrel and is completely buried by the N-terminal arm of the protein. The DNA-binding domain contains seven helices arranged in two semi-independent subdomains, each containing one helix-turn-helix DNA binding motif, joined by a 19 residue central helix.
Sequence:
MAEAQNDPLLPGYSFNAHLVAGLTPIEANGYLDFFIDRPLGMKGYILNLTIRGQGVVKNQGREFVCRPGDILLFPPGEIHHYGRHPEAREWYHQWVYFRPRAYWHEWLNWPSIFANTGFFRPDEAHQPHFSDLFGQIINAGQGEGRYSELLAINLLEQLLLRRMEAINESLHPPMDNRVREACQYISDHLADSNFDIASVAQHVCLSPSRLSHLFRQQLGISVLSWREDQRISQAKLLLSTTRMPIATVGRNVGFDDQLYFSRVFKKCTGASPSEFRAGCEEKVNDVAVKLS
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Subcellular Localization:
Nucleus.
Sequence:
MSVVNESRKRRRLIHSEKETRRLDLGEEDDLELFQKEAAWRRSREYEHLTVLEKKLYEYWESLVLKLDHYVAAALENHEQSFEELEKITASLYQPDDNLQTLDLSLAEFSLIKDAQNYLNKYASYFQAHEPTLQKLAKFGSFKLKETPNVHEWIDQRQVHFTSMINYRTSQLKLALLKRKLSFFREALNSAELEWKRVQQDQLTSASERSIENIADDIPASEPKAILENGEGCLNDNDNISKLKNNFQSQADLMQANINSKLDELSQKSTRAAQLYVDIMGITDERVSREPHYLELKGVLSSNEEKIESINRDLSSLFEDIQFFISQRTKRQKDIIDLKLACVKEKQQLIKTLESSLTQIRNERDSLVAKQQMQYTNNLFFDDMMLLLSNLSNARVAILEGYSNRLCIWDRIERSKTGEMNNVLDEKEEISASSALEKLIKNNSCLEAELPSMYAAFDQSQSRLLKKYEELETKEKKALEMHYEKARATQKYFAAMKARDILMTEKKTLKLAENKEHDYIGKLQEREHALTKYESSLKAELEVYKQIKEIYGKHSVEVLTEDKHLQVKQTKLTQKLEDLIESVQKSGEKLMIMHQKLFHLQEEHTILSIKASYNKKESHLINQAYETQEAQVYKGMLKCSVCNFSNWKSKLIPNCGHAFCSNCMEPFYEHKTSTCPQCETPFSVSDILTIHL
The following text describes a protein:
Function:
Required for nuclear migration within hyphae during vegetative growth.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Localizes to the plus ends of microtubules.
Sequence:
MPSADGSSSARPNGTSSRSDQLAWYKSQYEQLEAELADFQASSRELEAELEKDIEASEKRERLLKEKVDSLKYEVEEWKVRLEFTTFIADDGPRANLSLPRQTKYKQSKAEGNSAQNTLQKEITTLRDANRTLQLKLRDIEVANDDYERQARHTTSSLEDLESKYNVAIERAVLLEEEMRAGEQEREKLRIENQRLRDELSDLKIETEIIHEKLRNAELQNSRRRKPISLRSPSTPQTPDLFNRSPASSIVSSPLFSTPTLKTSLMSATATPPSPPISESSSSLRKSMNAMPGFPLQKASASDSSFGSRSLHGSRTQKHNNHSRATSYAFTSNRPTPSVTNRPGLPKPKPKPNENTNKHNNNARSSGLPKSGSLYQIRGLIGKMQKLEERVQSAKSKLPPPSDSPSRTSSRSGSILGESPVASTITARRNSRKRLSGSSFSSSVRDGDSVPSYAPHSRPSFGARTQGDSRPSSRTSYSSHSSVSHSTHPSVTPSTRPESRQSRTKTPLGHYSTNPTTESRRPRSSLSNPSNQNGVVNGMAHIDEDEDLAMHMSLRARISEIRETRLPSISTPTGLKKRTPSGISGIPAPRTLRTSTGFDRLEGDMGPPERKSNITDLGETY
The following text describes a protein:
Function:
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MAGPEFEFSHSNVLFQTQDGIPLTFYCLPGEVETLELIGPLVKHGGGIVTNRLARARGEYSIKLAADGKGGEHMHMYSYKYILDCVERNALLPLEPYKVSTVVSSDSATSAKGARREHFERYESINILMYIAKHGGEKPPVSGKKMWKDMQLFKVTKHPWSSMRSHYLKQLRGNEEEYQIKDRMRLLNMTGKELKELMGDAPPNNEDEEDINDMVNDNLGKEKAKMQPEVETGVPPYMVHNANMPPDVESLPEYAEVGNQPHLKTFLTKQQNMNHLTSPAPYASTSVVDTNLNENLNLEKSVSENGSEKWMPTFTREKRKNERRTPDAYTPDHKVNNDIYPQENSEGSQMSTSLSNPMYDNRPRSPYSDGSATDASSRRRRRAQNKPLVPPLNWADLLTPAPEHPPPSKVDSSPGTLPRSPYSSSHRSDRPTPDSPNTDVTLPCLPAHLEDTGQEPGLRIELPGYGYLDAPSDADTSVRDEDFENRDYDRERHLGEQTPASSMGDLESSVTGNRDSMIAG
The following text describes a protein:
Function:
May be involved in pre-mRNA splicing.
Sequence:
MREASHKDGKISKHPGVPWVTSLQTANSLTPEATPVAPDMKKTCLKPQAASPPIGLGEEAGSCGQTLSESNHGNGGPMTTPRSVTWSSPAALRSGLLPALLAFHPKMAAPVGPMKFWKPGTDGPGVNLSEERQSPAESGCVSVIYNPYVSLSIEQQRQKLPVFKLRNHILYLVENYQTLVIVGETGCGKSTQIPQYLMEAGWTAEGRIVGVTQPRRVACVSIAGRVAEERGALLGHEVGYCIRFDDCTDPQATRIKFLTDGMLVREMMADPLLTRYSVIMLDEAHERTLYTDIAIGLLKKVQKKRGDLRLIVASATLDAEKFRDFFNQNETSDPSKDTSMILTVEGRTFPVDVFYIQRRRLQWRRASGTFPRPLLHRPAGADFRRVLRGLGGIFMLFLPWNLSPPLPPPQKGYGQTWQHLHALSPPPQKEMDSPVPDYVKSTVETVMKIHQTEGDGDILAFLTGQEEVETVVSMLIEQARILARTGMKKHLRVLPMYAGLPASEQMKVFERVSHNVRKVIVATNIAETSITINGISFVIDCGFVKLRAYNPKTAIECLVVVPVSKASANQRAGRAGRNHSGKCYRLYTEEDFEKLPQSTIPEMQRSNLAPVILQLKALGIDNVLRFPFLSPPPAQSMVQALELLYALGGLDKYCRLTEPLGIRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFIIPPNQKSQAIREHRKFAVEEGDHLTMLNVYEAFIKHNKSSQWCQDHFLNYKGLVRATAVREQLKKLLVKFKVPKKSCEGDPDPVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPTSVLYAEKPPRWVVYNEVIQTSKYYMRDVTTIESAWLLELAPHFYQQGTHLSLKAKRTKVDDH
The following text describes a protein:
Function:
Inhibits papain and ficin (cysteine proteinases) but not trypsin (a serine proteinase).
Subcellular Localization:
Cytoplasm. Vacuole.
Sequence:
MKSLVLLLLVAVTVSSVVSKPLPEDSEAEVHKEFETWKVKYGKSYPSTEEEAKRKEMWLATRKKVMEHNTRAGNGLESYTMAVNHLADLTTEEVPKGLLPMPRPEEEEVDKEFEMWKTHNGKTYNSTEEEAKRKEIWLATRARVMEHNKRAENGSESFTMGINYFSDMTFEEIPKARLMVVFPTRDGGEEAEVDKEFETWKVQHGKNYGSTEEEAKRKGIWLATRTRVMEHNKRAETGSESFTMGMNHLSDKTTAEVTGRRLQDGEEAEVHKEFETWKVKYGKTYPSTVEEAKRKEIWLATRKMVMEHNKRAENGLESFTMGVNHFADLTAEEVPRGLFPME
The following text describes a protein:
Function:
May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Sequence:
MVSKMIIENFEALKSWLSKTLEPICDADPSALAKYVLALVKKDKSEKELKALCIDQLDVFLQKETQIFVEKLFDAVNTKSYLPPPEQPSSGSLKVEFFPHQEKDIKKEEITKEEEREKKFSRRLNHSPPQSSSRYRENRSRDERKKDDRSRKRDYDRNPPRRDSYRDRYNRRRGRSRSYSRSRSRSWSKERLRERDRDRSRTRSRSRTRSRERDLVKPKYDLDRTDPLENNYTPVSSVPSISSGHYPVPTLSSTITVIAPTHHGNNTTESWSEFHEDQVDHNSYVRPPMPKKRCRDYDEKGFCMRGDMCPFDHGSDPVVVEDVNLPGMLPFPAQPPVVEGPPPPGLPPPPPILTPPPVNLRPPVPPPGPLPPSLPPVTGPPPPLPPLQPSGMDAPPNSATSSVPTVVTTGIHHQPPPAPPSLFTADTYDTDGYNPEAPSITNTSRPMYRHRVHAQRPNLIGLTSGDMDLPPREKPPNKSSMRIVVDSESRKRTIGSGEPGVPTKKTWFDKPNFNRTNSPGFQKKVQFGNENTKLELRKVPPELNNISKLNEHFSRFGTLVNLQVAYNGDPEGALIQFATYEEAKKAISSTEAVLNNRFIKVYWHREGSTQQLQTTSPKVMQPLVQQPILPVVKQSVKERLGPVPSSTIEPAEAQSASSDLPQNVTKLSVKDRLGFVSKPSVSATEKVLSTSTGLTKTVYNPAALKAAQKTLLVSTSAVDNNEAQKKKQEALKLQQDVRKRKQEILEKHIETQKMLISKLEKNKTMKSEDKAEIMKTLEVLTKNITKLKDEVKAASPGRCLPKSIKTKTQMQKELLDTELDLYKKMQAGEEVTELRRKYTELQLEAAKRGILSSGRGRGIHSRGRGAVHGRGRGRGRGRGVPGHAVVDHRPRALEISAFTESDREDLLPHFAQYGEIEDCQIDDSSLHAVITFKTRAEAEAAAVHGARFKGQDLKLAWNKPVTNISAVETEEVEPDEEEFQEESLVDDSLLQDDDEEEEDNESRSWRR
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MALVAQAPAFQRSFLEALPAANWSHQTGTTRTHCWHNCQRQKESGQQLELRLLQSAQRLPAACARFKRRESRKKDVQCSATPRRDSLEPESERRVQEKAVGVAKALGGVNVYLVGMMGSGKSTIGKLLAERLQYRFFDCDEVIEGAVGAPVSQIFKENGEDTFRKLETEVLSQLARETRSVISTGGGAVLRKENWSSMHYGISIFLQVPIQTLAKRVTKNGHASRPLLNGGDATDESAETKAFTRLSTIWKDRKAFYENADVTVSIAGYEEGEEEMSTASLVEKVVHELETLLKERGVKKPQDSTGWVTEL
The following text describes a protein:
Function:
Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.
Sequence:
MLNKIKIDSESRLSEEQKIKDRRRNVIILIQRYLVNAGYIDSATKLGTESNLSLNQYDAADNIDLYMILCEFEQFYEMKFMKPPKLVKKVDGQNTPGLPRIPSSGKSSSTNTSNSNNQNSTGSNKKSTQQSKEKDNNNKDAKNEPDSLEIQGTGVQQKQSNNEESNQKDWFDPRVLKGLPDYSDVPEFQQLAAYLQRDICSENPNVKFSDIAGLDQAKKLLKEAVLVPLKYPHFFQGILEPWKGVLLFGPPGTGKTMLAKAVATECRTTFFNVQASSVVSKWRGESEKLIRVLFDLARHYEPSTIFIDEMDSIMGQRGSAGNEHEGGRRMKTELLIQLDGLLKSKKRVFLLAASNLPWDLDIAMLRRLEKRIYIPLPDQESRESMIRRYIPQEMSENLNYPQFAEALKNYSGSDIKLVCKEAAMKPLRRLLSQIEDIQVDVRTAKQKKQQNLTSYDDVRPGPVTETDFAEAMNQVKPSPSVFENQYLKWEKESGSHDFRLYTMAQNSVGRQYFLQENCPKNGFQKVISNSDGNIGGDLECI
The following text describes a protein:
Function:
Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
Sequence:
MTKHEFEVAMTCEGCSGAVTRILNKLGDVKFEIDLAKKLVWIESDRDVDALMETLKKCGKEVKYNGIK
The following text describes a protein:
Function:
Putative toxic component of a possible type II toxin-antitoxin (TA) system. Its toxic effect may be neutralized by cognate antitoxin Rv3098B/RVBD_3098B.
Sequence:
MVIRGAVYRVDFGDAKRGHEQRGRRYAVVISPGSMPWSVVTVVPTSTSAQPAVFRPELEVMGTKTRFLVDQIRTIGIVYVHGDPVDYLDRDQMAKVEHAVARYLGL
The following text describes a protein:
Function:
Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSB stimulates the catalytic activity and plays a role in substrate specificity. SPT complexes with this subunit showing a preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDVKHIKDYLSWLYYQYLLITCSYVLEPWEQSIFNTLLLTIIAMVIYSSYIFIPIHVRLAVEFFSRIFGGQHESTVALMS
The following text describes a protein:
Function:
Binds directly to 26S ribosomal RNA.
Sequence:
MPPKFDPTQVVDVFVRVTGGEVGAASSLAPKIGPLGLSPKKIGEDIAKETAKEWKGLRVTVKLTVQNRQAKVAVVPSAAALVIKALKEPERDRKKTKNIKHNGNINLDDVIEIAKVMRPRSMAKDLRGTVKEILGTCVSVGCTVDGKDPKDLQQEIDDGDVDVPLE
The following text describes a protein:
Function:
Required for the transport of neutral aliphatic and aromatic amino acids via the N system.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDSQYETKKNDPNAIMPYPESNDEHVGEVRGLGGGIMDKEPEAQEGHAKFHRLGWKRLTVVLIVEAIALGSLSLPGAFATLGMVPGVILSVGMGLICIYTAHVIGQTKLKHPEIAHYADVGRVMFGRWGYEIISFMFVLQLIFIVGSHVLTGTIMWGTITDNGNGTCSLVFGIVSAIILFLLAIPPSFAEVAILGYIDFVSICAAILITMIATGIRSSHQEGGLAAVPWSCWPKEDLSLAEGFIAVSNIVFAYSFAMCQFSFMDEMHTPSDYKKSIVALGLIEIFIYTVTGGVVYAFVGPEVQSPALLSAGPLLAKVAFGIALPVIFISGSINTVVVSRYLIERIWPNNVIRYVNTPAGWMVWLGFDFGITLIAWVIAEAIPFFSDLLAICSALFISGFSFYFPALMYFKITRNDAKSQGKKYFLDALNMLCFVIGMGILGIGTYAAIQDIMDRYDHGKVSKPYSCAPLA
The following text describes a protein:
Function:
Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate.
Sequence:
MSMKISEKKFNDRVGDGIQDSFMRGAVSSAQTRLYTNRLKAADELGNWEEWRELGEQIRQHTLENLDYYLMQLSENVSKRGGHVYFAKTKEEAAKYIQDVAKKKQAKKVVKSKSMVTEEISMNHALEEIGCEVLESDLGEYILQVDNDPPSHIIAPALHKNRTQIRDVFKEKLGYENSDDPYEMTKFVRKQLREKFMDAEIGVTGCNFAVANTGSLCLVTNEGNADLVMSIPKTQIAVMGMERMVPTMEELDVLVGLLCRSAVGQKLTSYVTVAGPIQEEEVDGPEEFHLVVVDNGRSQILGSEFRSVLQCIRCAACVNVCPVYRHVGGHSYGSIYSGPIGAVLTPLLGGYDDYKELPYASSLCGACTEACPVKIPLHDLLLKHRQVIVEQEGRAPLAEKLAMKMFSMGASSAALYKMGSKMAPAAMSPFTSGNRVSKGVGPLKNWTDIREFPAPSKERFRDWYKDHKKGGDK
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Sequence:
MAQNNSTAVMDVDTVEKEKKMKVKKSEMLKLNKFIYEVLKKVHPDIAISAGAVELMNTILTDMMLKLAQKASKHNKIRHKNSPLVEPDISAAVREVFPEDMAGLALLSALKSVIRMNVEDICHGITKIYHLGYRGFYFTPTLLQTSRGCFDLCKIVGAIKNQAFSQVRPAPSLCGAARYHPVRFHIGLSSCIMLQLVFGVFFQLGVVNRAMFGCLYCAYHLIFLFALGHLKPNQKGLIFFNIAKTGALPVGFGNECVYGFAVFSAPAASWGLLGFRLHVNMFFNLSI
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Sequence:
MGIEDVIRARARMPSAPDLPPSYDSIVPQTCRPQQQNYGNTASSQELVLVPRQSPPQYSTVFHSSQPIILPGQPVSQQQIIYTQPQPMLILPGQPMSAMEYVNYQPTLGAAPIVIQPGAPQLRRHFTTLSRLGKLLGEMRWMAVLAPVPGCPPGLEPLRGLKKITLRQKHELVEYDLIYAVKRYAIENQRGEHVFLATGKPEPATGWGPIRGHRIIVLDAYNRIPFTITCPFREDRLSCCASLDCCKQQTTVRGSGETFGTIRTGQACCATKLTIADRQGKKIINIDGSPCLNRCCFDVDYPLISATDYSTLGQITRKYRADGDSCRPDSCSARDRGHEMFEIEFPSDLSVRTKATIIGACIMIDFLDFESTKTRSAH
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTLTHHSTFIKGIEGSAEGEIEDVRQTTVFDPPFYGHPMLVPPSPSLTTMFRTRSTTPDEEGTAIAEIDQQDWDIMVKVPTYEYYGFVMYLVSMLGFGVYIVWALTPAPVLKFFEIHYYLSRWWALAIPTWLFVLVIYIHVVLNAYNTEVLTKPFSSLECIVDQYALVGEEDGAAHGRVVDLRLCDVNKQQLEET
The following text describes a protein:
Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MENLTQLFQNFPPCCAPDESGTLKRGCGRRWTSLKQHPRSCTEPLTETGNSSGLSTPSTTNTSPLPVAAGEGTRKSNWQVIEHFSSKDKGSLSSSLIAVGSVSRTPPAKENGSAPNSSPDLENHEVEAELLVSSIPKQSTGFFDKLLRLIKKLFSTHQFQNEQVEMLYQRYFLKMNQSNMTNLISLLLLLCVGFLLFAAIDIVMVHHSETDTLQEHSFRLDKSLVLICTSGCCIAIYGVLLAVLSKPAMNEVYLIIISYFILVTFLTLEICISFFSETERPLLGPTFSLATTYLTYALMPIRLKDALLAGTVLALTQVILLVYVGQLYAIADITSCFVILLCGNVAGVCTHYPREVAQRKAFLETRQCIEARLKIQRENQQQERLLLSVLPRHVAMEMKADIAGQPKEAQFHKIYIQRHENVSILFADICGFTTLSDQCTAEELVRILNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARPDHAHCTVEMGLDMIDAIALVREVMSVNVNMRVGIHTGRVHCGVLGLRKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLGNDYVVEPGNGGDRNSYLKDHNIDTYLIVAPSYRGGSTPYQNHSMNGNISKEMRVMGHGSQHGKHSSKLGFSEPPEREKNPEDEVNEYLMRAIDARSIDRLRTEHCRTLLLHFRDPVKEAKYILEKDRMLTLYFFCSTFCFTAIFLVQIVVMRRNDTAYLCSIPIMFLLILIPVIVYMENVNLENVHLKIFAVSKYIHKNRNIAQIFSFIMAVCIYGLVMLHTLSLPEEIQCLNSTIVDSNCTNFTVYSLNNDNKDCKPYFLIDYLLLLVFISMIACAVYQVLISLFKTIILLGGMAGFIAAYITYTKEVHAMHKFFCIPKQSETTLTQQYVNIVILVGFVIALILHGQQTEATYRLDFVWKLQATEEKEDMEHLEAYNRKLLANILPVHVAEHFLNSDKNNDELYHEQCDFVCIMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEDQFKYIEKIKSTGATYMAASGLTQNTCDMQGYRHVTAMADYALRIQEQLAEVNEHSFNHFRIRIGINVGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGVLDKIQVTKEVYQILSSRGYPLTCRGTIQVKGKGTMETYFLEGRCKKPTQSETNITVNPLANINSDCSKTFLPHQTTVLDTISEKI
The following text describes a protein:
Function:
Able to suppress the functional loss of YPT1. SLY1 is essential for cell viability. May interact indirectly, or directly with YPT1.
Miscellaneous:
MISCELLANEOUS: Present with 5780 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MAVEEIASRKDISLRDMQISAILKMLFLNKDLNNNDNITTITDDIFNQQEIIWKVLILDIKSTATISSVLRVNDLLKAGITVHSLIKQDRSPLPDVPAIYFVSPTKENIDIIVNDLKSDKYSEFYINFTSSLPRNLLEDLAQQVSITGKSDKIKQVYDQYLDFIVTEPELFSLEISNAYLTLNDPKTTEEEITGLCANIADGLFNTVLTINSIPIIRAAKGGPAEIIAEKLGTKLRDFVINTNSSSTSTLQGNDSLERGVLIILDRNIDFASMFSHSWIYQCMVFDIFKLSRNTVTIPLESKENGTDNTTAKPLATKKYDIEPNDFFWMENSHLPFPEAAENVEAALNTYKEEAAEITRKTGVTNISDLDPNSNNDTVQIQEVVKKLPELTAKKNTIDTHMNIFAALLSQLESKSLDTFFEVEQDPGSTKTRSRFLDILKDGKTNNLEDKLRSFIVLYLTSTTGLPKDFVQNVENYFKENDYDINALKYVYKLREFMQLSNMSLQNKSLEDGSDSAFKPSNLTLSGIYGLTEGKLQGGVGSLISGIKKLLPEKKTIPITNVVDAIMDPLNSSQKNLETTDSYLYIDPKITRGSHTRKPKRQSYNKSLVFVVGGGNYLEYQNLQEWAHSQLHNPKKVMYGSTAITTPAEFLNEISRLGASNSSNNDA
The following text describes a protein:
Function:
Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MQNMPNPAHFLLLIASRSHGCSPLLNRQTVSANEQERTFTTNLSLYKEKEGTFSKDGVKYPKWFTGKPVLYIQRYIMEIYYDDVKSKLWTEEEMNKKTLLHSFYLVDNITNFKSLSGKKIGNFCFKAKGHKTLFSSSINDCIIAAPTNFWPNLSSFNSDKNVIERIIEHSNADLLIGVPVLASGFQQQTVPGNYVKRIFSVSVVMSSFENRFLKELHEYLGKFYYRDFNVSHNFGLASSTHIQHIYYSEASGILELLPLLLTHVIVFLYIAFSVAKIEMVRSKWALAFSAVCTIFAALTMPLGISTYLQLDSTLQNREIYPYIIIIIGLENILIITKSVVSTPMDLEVRERIAEGLSKEGWSIWKTFFFEVITLLAGYFINVPAIQEFCVFASVAVISEYFLQMFFFVPVLAIEIRRIELTDLNKQNIRKEDALSEGEVEEQPIKSIDETFQSKGSDENFMSPSFTRQAKMPKRLAFAFSFWARTRIVQRVLLLCMIGYILYVITYIVFPSMAPNGSGNVQRVSVESPHFFSNMEVESESRLLWKIGLKIQRSVRNIVATESSEASSTTSQLPWEAWYRLLSLNNYHLAGMHIGLLSPVVLKREYSSKPGRMSVDVMNLTKQEDISVISIDGVYLVFAVLILFIIICYTLTVLMKYLLPTTRDILLWFIRMCQPPQYRTTIADNAPIILRGHGQDIECLDSNGSTLVTSCLEGKVIAWNVITGEQYCILRRNEILPLPRPRMDRLRNHYDDSLLGMPVRGNARMYGYMQGEIAPAHLGMTGSQSTYFGDVARSPVSPMYKTHRRSRSDEVNSRTIVESTFATSMRPVSVAQRLEENFGKGTIRQRRSDLSVLPDGQPLSSVDGYVSSKNILKEHESYNKRSLAENYFQNLYDSSSNAAIWCLLCHDNIIIIGCCDGSVEVWDIQSNYRLCCYRGCSSGVTCLSAIKNRIFVGRSYGRIDILQISTFKPYGGSSNNYGNDNPQLPQLASINLLCTKKWHHETLNTIKIAKEFAITASQDKTIKVMRLSDYGCTYTLHGHSDSVSCLNVDLSAGFFCVSGSADCSLRVWDLSNGSCVHHLSEEHTTAITVLECNHKYAVSISIDNVLCIWKYRAGVCIHRIVQSNNIIGGIALLSSALMVTGSQGCIVVWNVRSGRVMRTITLGEYDCSNFVSHMQKIDNTTVACSYGNEMYIISFSSVVEKKD
The following text describes a protein:
Function:
Promotes cell proliferation. Plays a role in tooth germ growth. Plays a role in the control of enamel mineralization. Binds the AMBN promoter.
Subcellular Localization:
Nucleus.
Sequence:
MLTAVCGSLGSQHTEAPRASPPRLDLQPLQTYQGHTSPETGDYPSPLQAGELQNLPLGPEVDFSQGYELPGSSSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPSHPGTEDGSWWDIHPGTSWMDLPHAQGTLASSGHPGALQAGLGGYVGDHQLCAPQPHTHPHHLLPAAGGQHLLGPPDGAKPLEATAPETHGLDASLDGAARPKGSRRSVPRSSGQAVCRCPNCLEAERLGAPCGPDGAKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGSKEEAAGTGAQCEGKSGAAAEPPGGKGKREAEGGGGGSAGAALSN
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MSDEDEYLRQQKLQADYDEFQKDVEDADGEHVLGMIERANEVKNKYKDDRRALIKDADLLKTVATKKTKHIKKYALAQPGTIDLKEVQNMVTRFIDTAAEIEDPAFDRVVDAFTGLSADPQAVPDFKRIAALGRVGMKHGRVARGASHLIGALEKDRPQKVRQMKPRQDPTEVGTQEKAKQLKGDEIDSTKNNIQRFGGIMRRRLTAEYNYRKQCGEPLPMLQAIIDPRSFESTVQNFFVFSTLVAGGMAKLSEYEDNTPVIDMCSEEETAKLVNDRDSRCPVVLEMDYETYEMILDAYEMRGQEPLLDLGDTTMGLSAE
The following text describes a protein:
Function:
Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit PolA1, an accessory subunit PolA2 and two primase subunits, the catalytic subunit Prim1 and the regulatory subunit Prim2) is recruited to DNA at the replicative forks (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (By similarity). Can add both ribo- and deoxynucleotides during elongation of the primers. Binds single stranded DNA (By similarity).
Miscellaneous:
MISCELLANEOUS: The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA (By similarity).
Sequence:
MPEQVTDQENQAPQQQTTAVHAYNPEVLQDMLPVYYRRLFPHLPFYRWLSYGSSEDAIFSNREISFTLQDDIYIRYLCFDTQAELEKEICSRNPIKIDIGPVMHSKPKNHRSIPGGLTPVQRELVFDIDMTDYDEVRTCCSGAGVCLKCWKFMVLAARVLDVALREDFGFEHIIWIFSGRRGIHCWVCDYQARHLDGRGRYAVAEYLNIITYASFAGGNSPRCSMGDRPHHSLKRALKIVEPMFEEIVLEDQNLFGTPKGVTKLLNMVHDDAARGELESYMQKNLEDGAHSRLVWESFIKYANSMRTSTTSAWSRKLKNIVAEIQLGLLYPRLDINVTRGFNHLLKAPFCIHPATGKVCVPFSVSAVAKFDPTTVPTITQLLHEINAFDDKSKSYMEAPEDKSRIKDHKKTSMFKGVVVFEEFLRKLERSQKSASLQF
The following text describes a protein:
Function:
Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide.
Subcellular Localization:
Periplasm.
Sequence:
MSDKDSKNTPQVPEKLGLSRRGFLGASAVTGAAVAATALGGAVMTRESWAQAVKESKQKIHVGPGELDDYYGFWSGGHQGEVRVLGVPSMRELMRIPVFNVDSATGWGLTNESRHIMGDSAKFLNGDCHHPHISMTDGKYDGKYLFINDKANSRVARIRLDIMKCDKMITVPNVQAIHGLRLQKVPHTKYVFANAEFIIPHPNDGKVFDLQDENSYTMYNAIDAETMEMAFQVIVDGNLDNTDADYTGRFAAATCYNSEKAFDLGGMMRNERDWVVVFDIHAVEAAVKAGDFITLGDSKTPVLDGRKKDGKDSKFTRYVPVPKNPHGCNTSSDGKYFIAAGKLSPTCSMIAIDKLPDLFAGKLADPRDVIVGEPELGLGPLHTTFDGRGNAYTTLFIDSQVVKWNMEEAVRAYKGEKVNYIKQKLDVHYQPGHLHASLCETNEADGKWLVALSKFSKDRFLPVGPLHPENDQLIDISGDEMKLVHDGPTFAEPHDCIMARRDQIKTKKIWDRNDPFFAPTVEMAKKDGINLDTDNKVIRDGNKVRVYMTSMAPAFGVQEFTVKQGDEVTVTITNIDQIEDVSHGFVVVNHGVSMEISPQQTSSITFVADKPGLHWYYCSWFCHALHMEMVGRMMVEPA
The following text describes a protein:
Function:
May be involved in the redox regulation of photosystem II.
Subcellular Localization:
Plastid, chloroplast thylakoid lumen.
Sequence:
MATASLVPTSKIFSVSPKSSASIKARSRVVVASSQQQQQPRRRELLLKSAVAIPAILQLKEAPISAAREVEVGSYLPLSPSDPSFVLFKAKPSDTPALRAGNVQPYQFVLPPNWKQLRIANILSGNYCQPKCAEPWIEVKFENEKQGKVQVVASPLIRLTNKPNATIEDLGEPEKVIASLGPFVTGNSYDSDELLKTSIEKIGDQTYYKYVLETPFALTGSHNLAKATAKGSTVVLFVVSATEKQWQSSQKTLEAILDSFQL