lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3.
Subcellular Localization:
Nucleus. Chromosome. Note=Nuclear in interphase cells, excluded from chromosomes during metaphase but reassociates with chromosomes in telophase.
Domain:
The N-terminal region seems to be responsible for association with chromosomes, thus excluding any involvement of the Zn finger in this process.
Sequence:
MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGWKKERVVAEFWDGKIVLVLPHDPSFAIKKVEDVQELVDNELGFQQVVPKCPNKIKTFLFISDEKRVVGCLIAEPIKQAFRVLSEPIGPESPSSTECPRAWQCSDVPEPAVCGISRIWVFRLKRRKRIARRLVDTLRNCFMFGCFLSTDEIAFSDPTPDGKLFATKYCNTPNFLVYNFNS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MPLKWVLHWQPNAGTTVNSQIINEVTQCVESINGVKEGRWKATITFYKPMIREQALAGDFPRDFLGIALPEQPNKYYLIIRLQRIVLEADSSIQMIMEKLQSYKSRVSLNFEGFQYQLGDFQLRVGKVLPTHSENLRGIVMEVEYLPISSMEKARQVMEDFMDIWQQALSKRSLPGHFMHMEPNFAEYGLADQYTSQHTAVQYATVMAQLIATVQAVQARN
The following text describes a protein:
Function:
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
Subcellular Localization:
Nucleus.
Sequence:
MIHPIQFTLTNHDGTLLFCVIKNTIFAYKTNGEDGHLDLAGEWVDDYDSAELIKAKVEKEQQRRLAENAAKKLKTNEGEAIERPGNQRRVPLPGKDPKVPVPGPGAPPVYQYIRCLQLSHDEKMLVACTDSDKAAVFFRIELHKDNCLTLFKRQPFPKRPNAVTFADDDAKLLLADKFGDVYAVDSVGEPEKKDPEPILGHVSMLTDIALVTDTKKSYVITADRDEHIKISHYPQSFVIDKWLFGHKEFVSSLCVPEWQSSMLFSAGGDSFIATWDWQKGLLMSSFDYSTIVEPHLTDAHLPPARFLANDGSDRREASISKLLTFKDLPYLVAVPEMTKIVLLLQWDATSGELILSQTLALPLNVVSATVTSANHKLILSLDNREQPGKNFVKIFTLENGKFEEEQAASSSVDEAIVRNLSERPEVQTTVDDIYPLYHVSQLRKRGEHYS
The following text describes a protein:
Function:
Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking. Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix. Has low flippase activity toward glucosylceramide (GlcCer).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein.
Sequence:
MQREPAAAEEPGCPGGRRRRRRRRRRPGDGRTRVVRSNLLPPPGVEDPAAGAAKGARRRRRGGAQRLADNRLKTTKYTLLSFLPKNLFEQFHRLANVYFVFIALLNFVPAVNAFQPGLALAPVLFILAVTAFKDLWEDYSRHRSDHEINHLGCLVFSREEKQYVNRFWKEIRVGDFVRLRCNEIIPADILLLSSSDPDGLCHIETANLDGETNLKRRQVVRGFSELVSEFNPLMFTSVIECEKPNNDLTRFRGCIIHDNGKKAGLYKENLLLRGCTIRNTEAVVGIVIYAGHETKALLNNSGPRYKRSQLERQMNCDVLWCVLLLICMSLFSAVGHGLWVQRYQEKKSLFDVPESDGSSLSPVTAAVYSFLTMIIILQVLIPISLYVSIEIVKVCQVYFINQDIELYDEETDSQLQCRALNITEDLGQIQYIFSDKTGTLTENKMVFRRCTVSGIEYSHDANAQRLARYQEADSEEEEAVSKGGSLPQRGSIGSHQSVRIMHRSQSTKSHRRTGSRAEAKWASMLSKHTAFSSPMEKDITPDPKLFEKVSECDRCLAIARHQEHPLAHLSPELSDVFDFFIALTICNTVVVTSPDQPRQKVRVRFEVKSPVKTIEDFLRRFSPSRLTSGCSSIGSLATNKATHKSGSNFLSTLSNDRTLLKLEEKLSQPTKAIASNGYSSGAASWAPEHTAQEQELEKEKEQEWELRYEAESPDEAALVYAARAYNCALVDRLHDQVSVELPHLGRLTFELLHILGFDSIRKRMSVVIRHPLTDEINVYTKGADSVVMDLLLPCSSDDARGRHQKKIRSKTQNYLNLYAVEGLRTLCIAKRVLSKEEYACWLQSHLEAESSLDNREELLFQSAIRLETNLHLLGATGIEDRLQDGVPETIAKLRQAGLQIWVLTGDKQETAINIAYACKLLDHDEEVITLNAESQEACAALLDQCLHYVKSKSPCSTPQKTEGNVSVGFSPLCPPSTSTTSGPSPSLVIDGRSLAYALDKNLEDKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRSKLKAMTLAIGDGANDVSMIQVADVGVGISGQEGMQAVMASDFAVPRFRYLERLLIVHGHWCYSRLANMVLYFFYKNTMFVGLLFWFQFYCGFSASAMIDQWYLIFFNLLFSSLPQLVTGVLDKDVPADVLLTAPQLYKSGQNMEEYRPRTFWLNMADAAFQSLVCFFIPYLAYYDSDTDVFTWGTPITAIALFTFLLHLGIETKTWTWLNWIACGFSILLFFTVALIYNASCATCYPPSNPYWTMQTLLGDPVFYLTCLIAPVAALLPRLFFKAVQGNLFPTQLQLGRQLAKRSPKKLIAPKETFAQGHLLGEPRTESSEQRSIKTSGPLSQDCTSQASWHVQQPACSPEASGEPNVVDMNMPLREDILLEELSGQAPGSVPREAILEGCSGASKMKPTSTSRTAPLSSIFNLPNFSSLNWISSFSLVSGLGSILQFSRNSLQMDKQDSEFLPSPPQPDQDLCGLSGQTTDYF
The following text describes a protein:
Function:
Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). Plays a role in angiogenesis. Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion (By similarity); [Soluble form of JAM-C]: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, desmosome. Cell junction, tight junction. Note=Detected in the acrosome region in developing spermatids (By similarity). In epithelial cells, it is expressed at desmosomes but not at tight junctions. Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts; [Soluble form of JAM-C]: Secreted.
Domain:
The Ig-like V-type domain mediates interaction with JAM2.
Sequence:
MALRRPPRLRLCARLPDFFLLLLFRGCLIGAVNLKSSNRTPVVQEFESVELSCIITDSQTSDPRIEWKKIQDEQTTYVFFDNKIQGDLAGRAEILGKTSLKIWNVTRRDSALYRCEVVARNDRKEIDEIVIELTVQVKPVTPVCRVPKAVPVGKMATLHCQESEGHPRPHYSWYRNDVPLPTDSRANPRFRNSSFHLNSETGTLVFTAVHKDDSGQYYCIASNDAGSARCEEQEMEVYDLNIGGIIGGVLVVLAVLALITLGICCAYRRGYFINNKQDGESYKNPGKPDGVNYIRTDEEGDFRHKSSFVI
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSTIGSLVFCTDCGSLLEGSVGDPTRILVCDVCGTRNKDTVPKTIVSESKPSSFPSSLRAKRSAIQTLTQADKRTEALIEKDCPKCGRKEMYFTTVQLRSADEGSTVFYTCVCGYKETTNN
The following text describes a protein:
Function:
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTYGKVYLVSGNKGKLAEVQSYLAHANIVVEAVKFDLPETQNSSAEKISWDKAVEAYRVVNKMPVGEPLRHGGTPVLVDDTSLEFDALCGLPGPYIKWFLDRLGVEGLLKMVKGFAAPGEKDSGAAAPAHRGANAVCIISLCHGVEEATGQPLVEQFRGVCRGALPPVPRGGVGFGWDSIFAPEAQTPAYAKTFAEMSVEEKNTLSHRAKALKMLTEYLKTHALELRGTKLVA
The following text describes a protein:
Function:
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
Subcellular Localization:
Mitochondrion.
Sequence:
MAAYKFLLPPLGRRILLPAARAWGAEASGCYFSTSCHRNTKFYTDPVEAVKDIPNGATILVGGFGLCGIPENLIGGLLKTGVKGITAVSNNAGVDNFGLGLLLQTKQIKRMVSSYVGENAEFERQYLSGELEVELTPQGTLAERIRAGGAGIPAFYTSTGYGTLVQEGGAPIKYNSDGTIAIASQPREVREFDGRHFILEKSITGDFALVKAWKADRAGNIIFRKTARNFNQPMCKAAKTTVVEVEEIVDIGAFAPEDIHVPKIYVDRLIQGEKFEKRIERLSIRKPEDSKAKQKPGDNVRERIIRRAALEFEDGMYANLGIGIPLLASNFISPDITVHLQSENGVLGLGPYPLESEVDPDLINAGKETVTVLPGSSYFSSDESFAMIRGGHVDLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSAQTKVVVTMEHSAKGNVHKILEKCNLPLTGKQCVNRIITEKAVFDVDKKKGLTLVEIWEGLSVDDIKKSTGCDFAVSPKLIPMRQI
The following text describes a protein:
Function:
Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism. May serve to degrade mislocalized alginate that is trapped in the periplasmic space. Acts preferentially on non-acetylated alginate or its precursor mannuronan. Is able to catalyze cleavage adjacent to either mannuronate or guluronate residues in alginate. Exhaustive digestion of alginate by AlgL generates dimeric and trimeric products. In addition to its enzymatic function, AlgL appears to be required for alginate export, maybe as part of a multi-protein alginate-secretion complex.
Subcellular Localization:
Periplasm.
Sequence:
MKTSHLIRIALPGALAAALLASQVSQAADLVPPPGYYAAVGERKGSAGSCPAVPPPYTGSLVFTSKYEGSDSARATLNVKAEKTFRSQIKDITDMERGATKLVTQYMRSGRDGDLACALNWMSAWARAGALQSDDFNHTGKSMRKWALGSLSGAYMRLKFSSSRPLAAHAEQSREIEDWFARLGTQVVRDWSGLPLKKINNHSYWAAWSVMSTAVVTNRRDLFDWAVSEFKVAANQVDEQGFLPNELKRRQRALAYHNYALPPLAMIAAFAQVNGVDLRQENHGALQRLAERVMKGVDDEETFEEKTGEDQDMTDLKVDNKYAWLEPYCALYRCEPKMLEAKKDREPFNSFRLGGEVTRVFSREGGS
The following text describes a protein:
Function:
Required for the formation of meiotic double-strand breaks and for the segregation of homologous centromeres during meiosis I. Interacts with the SFT and DSBC complexes, two subcomplexes involved in the formation of meiotic double-strand breaks. Stabilizes the SFT subcomplex on DSB sites and recruits the DSBC subcomplex onto DSB sites.
Sequence:
MENYTKSTTMCGKRKPTFEIYRESDFSKITNQGTVTAFDIISNKETFSESKQLKKAKSRNVTLVDKNTKADKRYKSEKLSDYLLNQEHHKNSPKIINDVLVIGKSDGLINSFPLSQNYISSSESQTSSGNVDIIGNDNSHASPYLPKFELKSQSQSNHSNVVKNQPIKLCKKTEGGTNLDHNKSINGAVKSGTSKSANKDRIYVFYEDEEVMEYRYIFGSRMQTKNHDINANNKRKIFYQNSFSNFHLLHKIIQPNYEPASAEERKLCIEILDEVLQY
The following text describes a protein:
Function:
Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis. Cooperates with Sir2A to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versions of the erythrocyte membrane protein 1 (PfEMP1) molecule, to evade the detection by host immune surveillance.
Sequence:
MSCMNYASRLSKNEYKGPLGEEEFFEDTEEEKKKVKELIEKIRSSEYIVVHSGAGISTSSGLQDFRGPTGIWTNEHLNELKNKKKRNHDFKDNKRKLKSNDINCKNTSDMCSPSFFHKEKKENTLNIVKRERYYNEDNVDMNACNERVVHPNHVYVNHEDDNNNNNNNNNNDNNLYNNVYNSVGSNDHTNKESILIKKENNSENVRKDIHDKVNTKNVKKIDVKETNNLDPENYVIFGKRKKKVIELHLALPSKTHIMINELINKNIIKFMITQNIDSLHHRCGKHFSKTAEIHGNIFTERCDFCGRRYLRDYLISTISFKPTGSLCFLCSFPPIGVCTDVLLDWNNSYEEFFHLNSIKHSQIADFHFCLGSSFYIVPASSYPSKKKYANANSYSCVINYQKSFLSKEVNLNIHSNVNNISDIIIKEFSLNPLSIRSARITIVRCPINTLDVICDKLISIHNIKMKHKSMRQHSIDYSQMGNKDEKYNNEKYVKRNMTECLYYNKEGECYEKRKYKLMEKKFFPNNQQNEFIPNRINIFEQKFHEHNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSSSSIDSSCSINSNYHISKNINPDFSFVENQSNIYENYKEQTFILICPMIINIKTVRLESFHKVYIKLLDDIKGLWFIKTNFSCILEVELWYHSFILLKLDFNKSDPFIQLNAWNVNVAYTYGDDIDDFDYFKNDENIKKPFNLYKNKYISNMRREGHVNNLYTLDNEKVKSNTSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDNNNNNISDHNIYDDHNNNNNKNHNNYDKDNSNESYYCSEILNEHVHVGYNPNNYEPNCKVYILAYLDNLRTRNINNNVNNNNFSRFNLTQSCKLLYNIYCVLNKDNEQKKNSTIKETYDKLDYFIKNFDFNRDSCLYTNNFINMLIQNERHGNQSRYKFRERRKRLLNDYSSCSSDDDQSGKNIFIFYNLYMNQYKKKEDNEINDIYKKYDVHEKNIYDESKQYVHKVRVRTDLINHKSVYKILKNNYLVNINNMKLMEKKNNSEKLFLINDKDNNSLLSINNKENFNCIPSRQNNVKKNSEYMHEEENNKTNSNENIARLNNNDFIQVMETEKQKKYNSFDKYNSDRSSINDTFDEIKYNKNNDNNNDDNNYDDNKNDDDNNNDDNNNNDDNNNNDDNNNNDDNNNGYIYSPVLFINKKFKLGELVYKIPKYVKPQKIYTPYKKISRNKKYSNTLQKDRYEKWKMLYEELINNENKTYIIDSVLYKEISYLPYWILNYVNDLFECM
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MNSLNLEAESSGRRGENVEKEIMICNSQMMINTNGMWRGENPLEYTLPILVFQSILIILVTRTLSIALSRLRQPRFIAEVVGGIVIGPSGMGMIPNYMNTLFPPRSLPVLETLAGLGLIYFMFIIGLQVDLGDVNRAGKKVWVVSAASIFIPFIIAVIAFYAFYYALNEKMDQRKNTGSYLVLICASISVTAYPVLARILAELKLLHTDIGKLAMSAAILNDSIAWILLTVANALVGAHRFFFAPIAIIFSAVVLVLVLYYTVRPIVSYFVSKTKEGEEIDENLLQAILMSVMVFGILADWIGIHAVFGAFVVGVVIPNGPVVAVLMERMDDFVTGFLLPLFFVIVGVKVDLRSLDSPHIYMFLIILLLVVSGVKIGSMVVATTFFGLPTHTGLSLGILMNTKGIMELIVLYIAFDKKVLYTQSYSTMIMMSIVMTTIVTPLSFMVLRSSRRLMIHDKRRTIHRAKPNTEIRMVACIHNTRNVPSIISLLEISYPTKRSPIFVHTVHLVQLKGHESAMLIVNDNQQDYSNKTRRASGVVPQGNLNRIQAQSDQIIKSFESYDMYAAGVSVHPLTIVSPYTTMHEDVCHLAEDKHVALLVLPFHKHHTVDGGMETTNIGIQTFNRNMLDNSPCSVGILVDRGIGGTVGFTDNGLHTIHHVVMLFIGGPDDREALAYASRVIDHPTINLTVIRFVNAAINYKNNPIIHDSSSDHPSSPDYAYLSSRGSSDLKVMPENEKEKEEAQAQVLDDECIKEFKAKSMNRDSVFYTENPVTNGEEMLESIRNMKNMNDLFIVGRGETKNSDLTSGLTDWTENPELGVIGDLLSSEDFTVTVSVLVIQQYKGIMSLASTDNKQHFERGENET
The following text describes a protein:
Function:
The small GTPases Rab are key regulators in vesicle trafficking.
Subcellular Localization:
Endomembrane system; Lipid-anchor; Cytoplasmic side. Membrane; Lipid-anchor.
Sequence:
MAGEGAGGEPSSPRAPERKEYLFKVLVIGELGVGKTSIIKRYVHQLFSQHYRATIGVDFALKVINWDSSTLVRLQLWDIAALQLKRAQLLLYINVNNTQMVHSIQSAITFALSTTGQERFGNMTRVYYKEAVGAFVVFDVTRGSTFEAITKWKSDLDSKVFLPSGGPIPAVLLANKCDQKKENSLQSPHQMDNFCKENGFAAWFETSAKDNMNIDEAARCLVENILANAKNFPVEENDDGSIRVDQEAMPAESKFQCC
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MKLFSDLDQKINKKREKREFDEEALDLTEQILGVNPDVSTLWNFRREIFLKWREDGGFTEKLVNVSRKELAFLQGCLKVNPKSYGVWFHRQWVNEFIPAPDWTQELLLCNMFLSFDERNFHCWDYRRIVTKKANITAHEEFKFSTEKITENFSNYSSWHYRSKLLLLIHPDPSGNPERIEETALMNEFELAQNAFFTDPSDQSAWFYHRWLLGRDQPELDVDCLYTRRQCRHLTTIVQLSKPAKIIQLSPSLFINSVEVLTEWRNVFCTDQPCHLWISLPLFHLA
The following text describes a protein:
Function:
Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion. In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates. Mediates the secretion of the riboflavin and biotin vitamins into milk (By similarity). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux. In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity). In inflammatory macrophages, exports itaconate from the cytosol to the extracellular compartment and limits the activation of TFEB-dependent lysosome biogenesis involved in antibacterial innate immune response.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Note=Enriched in membrane lipid rafts.
Domain:
The extracellular loop 3 (ECL3) is involved in binding porphyrins and transfer them to other carriers, probably albumin.
Sequence:
MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system DctPQM involved in C4-dicarboxylates uptake.
Miscellaneous:
MISCELLANEOUS: The DctPQM carrier is more efficient than the DctA carrier for the utilization of succinate at micromolar concentrations, whereas DctA is the major transporter at millimolar concentrations.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MHALARVWARLEEGLIAFLLAAMTLVTFVYVVLNNLYTLLYDLADLWEGGNETLLAIGDGVLTLAQEMTWSNALTKALFAWLIFLGIAYGVRTAGHLGVDVLVKLASRPVQRVLGVIACLACLGYAGLLCVASYDWVKTLFIAGIGAEDLDHFGIRQWHIGLIVPVGFALVFIRFAEILVRILRNRQTGLGLADEAADALKLTEHEEPKA
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVMKRRSGQRKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMAAIRRASAILRSQKPVMVKRKPSRPTKSS
The following text describes a protein:
Function:
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSTTTTVSAIRTVEEMSNITISSHPVVNEQIAILRDRSLKPSQVRSVVDEISRFLAYESTKTLKSPSVSIVPVLRSGMSMMSAFSKVLPDVPIYHIGIFREKSTLQPIEYYNKLPKKSTDTAVILDPVMATGGTANAVITTLQEWGCKNIIFVSVLASEQALTRFSNIPGVEFVIGAVDKSLDAKGYLVPGVGDIGDRLYGATA
The following text describes a protein:
Function:
Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release. Confers NAADP-sensitivity to the two pore channels (TPCs) complex (By similarity). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Colocalizes with type 1 ryanodine receptor (RYR1).
Sequence:
MFRGADGQASKSGFRSMKPPGGESNDIFGSPEEGVPSSKPHRMASNIFGPTEEPKNIPKRTNPPGGKGSGIFDESTPVQTRQRLNPPGGKTSDIFGSPVTATAPLAHPNKPKDHVLLCEGEDCKSDLKAATNSTPRGEQGEKGSSTEAEPAKIPEPIPTVDSHEPRLGPRPRSHNKVLNPPGGKSSISFY
The following text describes a protein:
Function:
Transcriptional repressor required to restrict transcription of ECB-dependent genes to the G1/M phase by repressing their transcription during the interval from late G1 to M phases. Genes that contain a ECB (early cell box) element in their transcription regulatory region are transcribed only during G1/M phases. In vitro, is capable of binding to the DNA of the leucine tRNA gene.
Miscellaneous:
MISCELLANEOUS: Present with 861 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSQETKMLPSLSSLLSGTEISSSPVSPSFTNPRTSFHLDDRGTIKLPPLNTSINRPRSVESALRHTVTSLHENSSAYGDDMLKHTQSDSALSSQLNSSQETVDESHENLLLTPLNSKKRDYSVSSKKNDILTPLSAAKSIIIPSASKEKRRAFAFITHSQETFPKKEPKIDNAPLARRKRRRTSSQELSILQAEFEKCPAPSKEKRIELAESCHMTEKAVQIWFQNKRQAVKRQRIATSKSTTIIQTVSPPSPPLDVHATPLASRVKADILRDGSSCSRSSSSSPLENTPPRPHHSLNRRSSTPSIKRSQALTFHLNPQKKTLTPVKTSPNSRVNKLINSIDHSPSKAKRPVSNPSGSPKRKRKFGFKIVDQQPLKDLDPNAFRG
The following text describes a protein:
Function:
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment); Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Subcellular Localization:
Golgi apparatus lumen. Secreted.
Sequence:
MLTAALLSCALLLALPATQGAQMGLAPLEGIRRPDQALFPELPGLGLRAPLKKTTAELAEEDLLQEAQALAEVLDSQDREPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTAMNPCSRT
The following text describes a protein:
Function:
Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MPLSAAIKSSLSVSVRADAKGLVGFANTGYNGITVLKQTYWTSFYMKGEYSGTVLLRLTGTDSGTVYGSRNLSVKSTGGKWTQYETTFEANESYVAENEWQLLFDAATAKGHPLHFGLVQLFPPTYKNRTNGLRNDIARPIADLKPKFLRFPGGNNIQADRPGDWHYPNTDALGLDEYLWWCEDMDMVPVLSVWDGKSYGGIVSGEELQPYLDDIKDELEVTLPLTLLSHPLRAYLTPNTNEQYLLGPPSTPFGALRARNGHPDPWPIQYIEIGNEDDYSGGCDTYPDRLVQIYDTIHASYPNLTLIANNMDENCLPEIPLPGLWHDYHYYRSADDLVAMFNYWDNHDRGDRVLVGEYGCRNDSNPDGVFWSFMQGSCAEAVHMIGLERNSDVVMMAAYAPLLQHFGYTQWSVCTPSASLAYLGIHPADRGEEQPTLFGFESRPNSLTLSTSYYVNRMFSTNQGSTVHKVHSTAGFGPLYWVATSNETAYQVKLANYGAANQTVNIRVPGVGRGVLEMISGPKDASNLPGDIKIVPVSRNIRAGKEGYTVHMPPWGVAVLVVVFK
The following text describes a protein:
Function:
The active factor is excreted into the culture medium by haploid cells of the alpha mating type and acts on cells of the opposite mating type (type A). It mediates the conjugation process between the two types by inhibiting the initiation of DNA synthesis in type a cells and synchronizing them with type alpha.
Sequence:
MKFISTFLTFILAAVSVTASSDEDIAQVPAEAIIGYLDFGGDHDIAFLPFSNATASGLLFINTTIAEAAEKEQNTTLAKREAVADAWHWLNLRPGQPMYKREANADAWHWLQLKPGQPMY