lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Involved in the maintenance of ribosomal (rDNA). Required for efficient fork arrest at the replication fork barrier within rDNA. Involved in the maintenance of mitochondrial (mtDNA). Required to maintain mtDNA under conditions that introduce dsDNA breaks in mtDNA, either preventing or repairing dsDNA breaks. May inhibit replication progression to allow time for repair. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. May have a role in conjunction with DNA2 helicase/nuclease in 5'-flap extension during Okazaki fragment processing.
Subcellular Localization:
Nucleus. Mitochondrion.
Sequence:
MLNANKSIIRLATYSIRNRIHHLRTLHSLNYINSRINIQDTNHIRPTCPCGSKQFMLESELDSALIEFLDNDDPFSDSEIKESDDLSKGQSHVYNGSPVTKNSILQIEKQQIQKSPRPTETNKRMQIRKDPDQNDNVDDDSLSSTFEFSDMDDDFMEALKAAEEITGNNTNCIKRTASTPLKKPIAKSMKNSSTPSKSAGKKYCKYIKTSSPSPSHYLIRESGSGVDILEGSPNKVQADNASPFRITSSFSSPSQIQNQGVGANPGPKSKAEQNVSSASQSSSPPMTVSQVRNPFKVPTQFRRNYSTRPITNQGSDTKKGNSHHTILLATQKPGVPFSNPSDRSYHKLEKTEGINEAQSEAKNVKPIILSNEQEYVLKQVLSGVSLFYTGSAGTGKSVLLRSIIKSLRDKYPKGVAVTASTGLAACNIGGITLHSFAGFGLGQGKVENLIKKIKRNKKAFTRWRETRVLIIDEISMVDGHLLNKLNEIAKNLRRNNRPFGGIQLVACGDFYQLPPVVKKTAHDGTELDDVEVFFAFESSAWKETIQRTITLKEIFRQKGDQRFINMLNNLRDGNVPDDTARDFCRLSRPLKCPEGIVPSELYATRYEVDMANSRKLNTIQGDVVVYNSVDTGILPEPQKTQVLTNFLAPQVLNLKVGAQVMCIKNFDDQLVNGTLGKVIDFVDRDTYMKSESKENPSTETSDEVSGLNDYIFNDFQKPKKVVKEDAPIAEQVLFTGQLSQKVEEESESSKRKSKLKDDLMKDYKNKKYPLVKFLLPDGITFRTVVVEPEQWTTEDEDGTVLVSRIQFPLILAWSLSIHKSQGQTLSKVVVDMKKIFENGQAYVALSRAVSRAGLQVLNFNRSKVASHRKVIEFYKNLSSHEKESRSGQQRLNFMQTSVKSVARAQI
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MFRPSTSLALRSTLRQLASASNQPIPPGSEINAVKRTVATILPPIRLYRRIIRAHRRLDPDMRAVGDNYVKDEFRRHKNIDNPLQIIGFLSSWKMYLDQLEVQQGQPGGFRGQRLDPQLLEKMSDEQIYQIHELMTATQEAYSDKAQAFPPEKQRELAEKAAADAGLSVKKDE
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Subcellular Localization:
Cytoplasm.
Sequence:
MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG
The following text describes a protein:
Function:
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.
Sequence:
MEEVELQRNEGLIARTPATIKVISGDAEVWGVPFEEISLSQEAMDLLITSNHGAKLNIIGSNFIKINDPIPEWWHNLLEKIPDKTVMFIGKVDSGKSSSILYLANKLLLNGTRVSIIDSDIGQSDLGPPGVISSSNLRDPVYQMKLLDPEFMYFIGDKSPRGHLLQFLVGTWEAFRDVKEKTILINTTGFVDGAAARTLKKLKIELLQPDVIIFIERSEGELRHLIRSVPIGAKAVNVRSPVRDLPKDKGYRSLCRKALYKKYLENGNRRTFDLRKVRIENTFLFTGDERREYAPFLSELMGSGVIWVEESADMLLILSEGYVERMKVKKLEDLMRKEVKCAPINVYKNLYVGLKLNGRCSGVGIMESFDPLDGKAEILTRYGGDVDSIIFGFIRLSEDGEELGMREVDSP
The following text describes a protein:
Function:
This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. Also, involved in the degradation of oxidized and glycated proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MEVVKCGACAGAGSGSGGRGGIGIGGACVGRNLVRAYSPRRLSGPGPASAPALGVSSSSSSSSSPSRSCRRLFSEARPLLSRRAFSRTLCRKRVVSAMDQSSEKSAASGTTATTEVTGAKEAELLQAFCGIPSIDKAWTSSSRRGSGGVDVVVAMSSVNLQANAKRTFISTVYIPDPSGNAEDYHWSPFPFELGGALLIVPSPSGTKLLIVRKADPIAKEGPAAIKLEIWGPGQLLKELFVAPSVHGSLYADGWFEGVSWSNDEESIAYVAEEPSAPLPVYGQSLFATGQSSSRSEAESDASSWKGQGEWMEDWGESYTGKRRPMLFVASINSGCVQRVEGIPKDISVGQVVWAPAPPPGEPAQQLIFVGWPSYATNFSTARKLGMKYCYNRPCALYAIEAPSESRVVAQAAVHPVKLTGEVSSAVIPRFSPDGTQLVFLSAKAAVDSGAHCATNSLNAIDWPTDGVVSANLPMREVVPVVMNPREDGFPGLYVSNIIAQPWLSDGSTLLFTSAWRSMQVILAVNIESGAITRITPHDTIASWSLLGVQDDVVLAVSSSPTSPPCLKLGNNLSSSTNTGSGKKWDWSNINIPSLKFPSKVETALATMTYEVLQVPLERAEPTNSESGGPKPSIEVIYVSPRIFHSKQPQGAKKSDVPPLIVVLHGGPHSVSQTTYSRPLVFLSALGFSLLHVNYRGSTGFGEEALQSLRGNVGRQDVDDVLLAVEHVISEGLAERQRIGVLGGSHGGFLTSHLIGQAPDAFVTGVLRNPVCNLSSMIGVTDIPDWCYVETFGKDALSAYSDAPSISDLSMFYKASPIAHLSKVKVPTLFLLGAQDRRVPASNGLQYVQALRARGLEVKVIIFPEDMHAIDRPQSEFESFLNIGTWFKRFLLNSGA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MHPSSTDPEVVSFAAVSEPFDCRDSTILFPLHSLLDASQRAAHGHGEDKHQCRYCTYSSDVVSNVIRHERMHTGEKPFECHICGKVLTRKTNLVAHLRSHTGEKPFSCQVCGKTFSKKKNLGYHMMTHTRARGRTCAASARGGSVTRPA
The following text describes a protein:
Function:
Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
Sequence:
MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPTSKENFKEKCPQNASDSYGHKQYPANQGQEVEYLVTGTHPYPPGPGVALTADTKIQRMPSESAAQSLAVALPSSQTRVDANRSAPAGGEYRHPGTSDRSQPAGMTSAVMEAGNAKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYKEDDTATEETHPVSWKPEIIKRKRF
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine diphosphate (ThDP) into mitochondria.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MDRCVLASSVLASQIPLRVQRYLFPLSLSLSLFPKIFNGGSSLSFLIPSFQTDLKKGDCFGMEEPGQLKRAAIDATAGAIAGGISRTVTSPLDVIKIRFQVQIEPTSSWAMLRSNWSGTSKYTGMFQATKDIFREEGLAGFWRGNVPALLMVMPYTAIQFTVLHKFKTFAAGSSKTEDHVQLSPYLSYVSGALAGCAATVGSYPFDLLRTILASQGEPKVYPTMRSAFVDIVANRGFRGLYAGLSPTLVEIIPYAGLQFGTYDTFKRWSMAWNRYRAANSSLTDTENGLSSFQLFLCGLAAGTCAKLVCHPLDVVKKRFQIEGLPRHPRYGARVEHHAYRNMWHALRQILLLEGRAGLYKGIVPSTVKAAPAGAVTFVAYEYTSDWLESIWT
The following text describes a protein:
Function:
Plays an essential role in early embryonic development. Plays an important role in the regulation of centriole duplication.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MSTSINLKNTQFYKEVRGVSMENQRNLRSMSNRMLSVNFPPSKCALWDPAPMGDPFGLHFSYYRNPRLLVSEKALRLSSRHAKTGRKPFSCFLLGTFSVDEDEEGVTLTVDRFDPGREKTGSGSSKVPTAQLPGDFIIPCTISIGKGSNNVIVHTPEDFTSSFMSLQSHLHGKEALDLAKLLAMRAHITYTENMDNLHFDLHWAAVTVANTFESTPIKPVPIIPTALARNLGSHNNIAHLQGTHKSGYLTMDQTRKLLLVLESDPKVYMLPLVGIWLSGITHIHSPQVWAACLRYIFSSSIHERVLSESGSFLIILYSLTHKEPEFYECSPCVKHDPLGFQLLTCQDTLHLFKNAEVSKNPLLRFELSSECQELEADLFNETCKNKSTTVFKQSPLPNKLSTSDHDSGVEEEDFSPRPSPRPHPSVQQVSRIHPSVPELSLVFSSFFDPKSASHNPENRTRNNSPFSSTPQNVNNMFAGAPKPNKEPQPCDNQASGLLPRPAPSLNTNSTAMKPSKVKSSPADYQPPHLQSSNQIRRNSTSTSSAFSTPRSGCSPDSTVHQVKGSCEQEQNINGSAQPQGTTPLMRSGSYSRQVSSNFPNHNVTFPLHSRHVAEVAKPSPNLAPFHQTNVCTSCHSLVSCHSKNCWPAMGHLTYHTMENPPETCESVMPAYQNVVCPSVCCPQTAGKTEFCSPVDLVLLSPGRRDSLPLNPCSPHTCRHTPPPVIPTATGMLGLSTEAYRLFAEQDKQLKLLQAQIQRLLEAQAAESEPSKTTIPNNSKQKQVESVSTEQEIKTSVSIAVSTGASLFWNPPCPEKEESMDKQDDSAFCNEFSVNVNTEDTSHATITSSIRAVDIHSFSESTQLTDRGNCTASLHVSHERDDASYPLPDVQQDINNSKSLSNQTDHTESPNTAEIDSGVSAVPPEKFYQDLLAQVNNLLKTSSTEDEMTSTKIDSGHIIEKTESLPCNPTENNDKNVLKATLKQLKSLGVNIDMNTSELQATKADTADSASILACINPEAVIPRLNYMSFSNIGLSGFVPNGVDLSMEANAIALKYLNESQLNQLSLSHANKNKQSDSISYNSLLPGTTEKSMVGLSLISPSNMSFATKKYMKRYGLIESSDSSMEEPDLANASSFALTPMSSDSTSENRLFFNDSCKDGNFVTCEEQKRKNADVDSAIGWAHHPETNKLRNITNEISGKLINVAPLQEDRPLHFLKDLKARTKLSAGKAQFTQHPEKENTGDVQFFHEKHDGFSGKKSLGGPSTVGDILDVNRLRQLPKLF
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MHTALICAVLLTMAMVLRQQAQGAVKDNEHGGDCAALCGLIQFAEPNTPAISLPQEITEIADELLAVNLSMSEAALQQLVTKHKDKSWDDIPASDKPAAQPYKEHWQHWQKLAADPKPETVKFKLEQFRKVSQNTMAKNKFHLIADAALELATEAKMLLQKKTKTDIDTKLTKALNGNNAPTNTFTFSGKTRSQLCGTGTTTPGEQAGKALLVDLLCICAGANTDTTAGKSCCKGCETNPNHDEWQPATNAKLRAEHIAKQCPTTRATADKSTTKLHHLLGDFYTQVNTAKGTGQEMKYALGTVGGNGNDGCTGKVGSTNNGRCVKYTDNSILKGTPQLDWVQNLIDAAADYDARTDNMNKIQRIADKMEVLNKTATALLWEQQPVPILQTKAATTTTHQTAEETKQECKAITKAADCNSNGNCKWTKPDVKTGTHCELNTTTSEQAAQTGGGAAGATTTVKCSDYGTKDKCEEVNKGKDKPVCGWRIGKDNEDDKGTEKCRDSSILPNKHFALSVVSAAFAALLF
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 7000 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MLSVVAIPKICVTGPARRCFFHTAKKLYADDYKPAAMSSNAPSLTKDQAKKRELKRLVQRKAEAKRPATASPLYMPVTKALRYLRAAEVGRPQSQQTINLTTLVVGERGTAPLSGSVTFPKPLRYIKIAAFTNDESKLEELREKYPNHLIGGADLVAKIKSGEISVDFDKAFATPDIVPALQSQVARILGPRGVLPSVKKGTVSDDISSLLQESLGSMPFRQRGNSISIGVGKCYFTDREILQNIISARAAFKTAVDNQKSKKPNILSKTTLSSTHGPGIVIDFA
The following text describes a protein:
Function:
Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
Sequence:
MGQKINPIGLRVGIIRDWEAKWYAEKDFASLLHEDLKIRKFIDNELKEASVSHVEIERAANRINIAIHTGKPGMVIGKGGSEIEKLRNKLNALTDKKVHINVIEIKKVDLDARLVAENIARQLENRASFRRVQKQAITRAMKLGAKGIKTQVSGRLGGADIARAEQYSEGTVPLHTLRADIDYAHAEADTTYGKLGVKVWIYRGEVLPTKNTSGGGK
The following text describes a protein:
Function:
May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium.
Subcellular Localization:
Cytoplasm, cell cortex.
Sequence:
MRRPPGNGEAASEGPGGWGLWGVQESRRLCCAGHHRCEQALLQIGINMMALPGGRHLDSVTLPGKRLHLMQVDSVQRWMEDLKLMTECECMCVLQAKPISLEEDAQGDLILAGGPGPGDPLQLLLKRGWVISTELRRIGQKLAQDRWARVHSMSVRLTCHARSMVSEYSAVSRNSSKEMDQIEKLLMEKCSELSAVTERCLQVENEHVLKSMKACVSETLSTLGQHFGQLLELALTREVQALVRKIDASDNIYTTESTTGNLFSLTQEGAPLCRIIAKEGGVVALFKVCRQDSFRCLYPQALRTLASICCVEEGVHQLEKVDGVLCLADILTDDSHSEATRAEAAAVVAQVTSPHLPVTQHLSSFLESMEEIVTALVKLCQEASSGEVFLLASAALANITFFDTMACEMLLQLNAIRVLLEACSDKQRVDTPYTRDQIVTILANMSVLEQCASDIIQENGVQLIMGMLSEKPRSGTPAEVAACERVQQKAAVTLARLSRDPDVAREAVRLSCMSRLIELCRSPSERNSSDAVLVACLAALRRLAGVCPEGLQDSDFQQLVQPRLVDSFLLCSNMEESFV
The following text describes a protein:
Function:
Extracellular signaling peptide that represses plant growth rate. Regulates shoot gravitropic responses. Represses primary root length and lateral root initiation, probably by repressing the CEP receptor CEPR1. Regulates systemic nitrogen (N)-demand signaling. Mediates up-regulation of genes involved in N uptake and assimilation pathways.
Subcellular Localization:
[C-terminally encoded peptide 5]: Secreted, extracellular space, apoplast. Note=Accumulates in xylem sap.
Sequence:
MESFMGQKKTLYACYFLMLVFFLGFNCVHGRTLKVDDKINGGHYDSKTMMALAKHNDMMVDDKAMQFSPPPPPPPPSQSGGKDAEDFRPTTPGHSPGIGHSLSHN
The following text describes a protein:
Function:
Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKQWRLLSFVSLLALLLGGCGKAFQSTLIPQGEVAKMQYDLLLLASAIMVGVVLVVTIIFLYVIVRFRQKKGQEDYIPEQVEGNHKLEIIWTVIPIILLLILAVPTVTYTFKLADVSAMEKKNIDKDTIVVDVTANLYWWEFSYKSEKIVTSQDLVIPTGKKVYLNLKGADIKHSFWVPSLAGKMDTNTDNVNKMWLKADKSGTYNGFCTEFCGPSHSLMQFKVKALDESEYKKWLADMKKIDGKKEVASTKAQEGQEIFNKSCIGCHAVGSNDSRPPSARIAPNLANFADRDMVAGIAENNEENLKKWLKDPENMKPGNKMTGKYGNLTDDQIDALNAYLQTLKVEK
The following text describes a protein:
Function:
Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3 (By similarity). Involved in transcription elongation as well as in transcription repression.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The AWS and SET domains are necessary for transcription repression.
Sequence:
MQTASSLSVLTPLNEENVDRKSSWSKDTIAVQAVGSSPSSSSSHDFESKEDAEGMNKDESAPSPSTSSPSSASSRSQSKYVRKEALPPQLFHHLDSAKDKALTTFEEIQECQYASANIGKPPENEAMICDCRPHWVDGVNVACGHGSNCINRMTSIECTDEDNVCGPSCQNQRFQRHEFAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHSCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQPCYCGEPCCVGYIGGKTQTEAQSKLPENVREALGIEDEEDSWENITARRQRRKKGIDETSKIIEEVQPTPLTSESATKVIGVLLQTKDDLLTRKLMERIFLTSDPSVCRSIIALRGYNIFGLMLKKFSIDIEFILRSIKTMLSWPRLTRNKIQDSNIEPVVQEFCDHENEEVKDHAKTLLKEWESLEIAYRIPRRKPGQVAPQSTNAEPSNNQSNPPLRDQEPQRGDKGDIKSAINNSTEDLSKKHPALHSSRPSDSRSRSKFGNDYQSHSKHNLFRKNSFPKRRRLSNSDTPSETTTPNNEQEQVSNQANKVDLNKIISAAMESVNQKNVLKAQKEEEERIAQQKREEKRRLAYEESLKRHAKKLHEKKTKSSQDATIDHHLTSHSPESIAFKAVLAKFFANKTARYQEKLGKAEFKLRVKKMTEIILKKHIQLVLSKKEKALPDELSDSQQRKLRVWAFRYLDTVVSRSGTATTTPTDSPSIGESPKKAA
The following text describes a protein:
Function:
Zinc chaperone that directly transfers zinc cofactor to target proteins, thereby activating them. Zinc is transferred from the CXCC motif in the GTPase domain to the zinc binding site in target proteins in a process requiring GTP hydrolysis.
Sequence:
MIVKAIPTNIITGFLGVGKTSLIKQLLKTKPEGETWAVLVNEFGEVGIDACLLAANNSGVQIREVAGGCMCCAAGVPTQVAINQLIARAKPDRLLIEPTGLGHPNEIIKVLSAPHYQHVIRLQSTLCLIDARKLMDERYRGHDNFIQQLQVADVIITTKTDLYPEFEALHDQQLDLELAQYLNALQLVDTPVVEHSASQGLSTRLLEYLKQPRRDIPRAPSYKAASVVSQPQSLLLNSAETLGLQGVFAKSVSEDGDYIEPQERVRKQNQGEGCFSCGWVFNPLQEFDFDKLMQFISEQTQVNPTLLRVKAVMITSDGIAGINWSDGDMAVTELDDSLDSRLEMIATQDLDWDRIEQALVECLVG
The following text describes a protein:
Function:
Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).
Sequence:
MVRVNRKQALQMIKEASIYELGREADNIRESLHPEGIVTFVVDRNINYTNICINRCKFCAFWRPKEHKEAYVIPHKELAKKIEETIQKGGTQILLQGGVHPELGLNFYVDILRFIKDNFRIHVHGFSPPEISFLAKKEGLSVKDVLLKLKEAGLDSIPGGGAEILSDRVRKIQSPNKISSAEWLGVMREAHRLGMKTSATMMFGSIDTEEDIIEHLDSIRSLQDETGGFTAFIPWSFQPWNTELKKENPELMPAGAVKYLRVLALSRIYLDNFKNIQVSWVTQGIKIAQVGLRFGANDFGSTMLEENVVRAAGVSYRVTMEEIIEAIRSAGFRPAQRDTYYNVLRMF
The following text describes a protein:
Function:
Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of sensory cells excitability in the cochlea. KCNQ4/Kv7.4 channel is composed of 4 pore-forming subunits assembled as tetramers. Promotes the outflow of potassium ions in the repolarization phase of action potential which plays a role in regulating membrane potential of excitable cells. The channel conducts a slowly activating and deactivating current. Current often shows some inward rectification at positive potentials. Channel may be selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) = Rb(+) > Cs(+) > Na(+). Important for normal physiological function of inner ear such as sensory perception of sound.
Subcellular Localization:
Basal cell membrane; Multi-pass membrane protein. Note=Situated at the basal membrane of cochlear outer hair cells.
Domain:
Each channel subunit contains six transmembrane segments (S1-S6) with S1-S4 forming one voltage sensing domain (VSD) and S5-S6 contributing to form one quarter of an interlocking pore-forming domain (PD); The CALM binding domains correspond to the first two membrane-proximal helical regions that interact with a single calmodulin/CALM molecule forming a clamp-like structure. CALM N-terminus binds to the second helix in both calcium-free and calcium-bound forms and regulates channel trafficking. CALM C-terminus binds to the first helice in calcium-free form; this interaction is disrupted by calcium binding which regulates channel electrophysiological activity; The C-terminal assembly domain carries the major determinants of tetramerization and subunit assembly specificity. Its coiled-coil region is four-stranded.
Sequence:
MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGGQRSSAAQKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIIRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDTSRAYLTATWYYYDSILPSFRELALLFEHIQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSASFCPGESSRMGIKDRIRISSSQKRTGPSKQHLAPPPIPTSPSSEQVGEASSPSKVQKSWSFNDRTRFRASLRLKPRCSAEEGPSEEVAEEKSYQCELTVDDVMPAVKTVIRSVRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQARVDQIVGRGPGDRKTREKGDKGPSDTEAVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGTVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
The following text describes a protein:
Function:
DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
Subcellular Localization:
Chromosome, centromere, kinetochore.
Sequence:
MRSVGAGEIQSSVEIPGTKLRVMEASRGSVEAAALSPEQAALYQRYVKEAKEATKNGDLEEAFKLFNLAKDIFPNEKVMSRIQKIQEALEELAEHGDDEFTDVCNSGLLLYRELHNQLFEHQKEGVAFLYSLYRDGRKGGILADDMGLGKTVQIIAFLSGMFDATLVSHVLLIMPTNLISTWIKEFVKWTPGMRVKTFHGSSKDERTRNLNRIQQRNGVIITTYQMLINNWQQLSSLNGQEFVWDYVILDEAHKIKTSSTKSAICARAVPARNRILLTGTPIQNNLQELWSLFDFACQGSLLGTLKTFKIEYENPIMRAREKDATPGEKALGLKISENLMAIIKSHFLRRTKEEVQKKSSTPEEIRFSEKNPDGDAICKMPSLSRKNDLIIWIRLRPLQEEIYRKFVSLDHIKELLMETRSPLAELGVLKKLCDHPRLLSARARHLLSLGSVKFSVQGENEGEDASDVDHIDHVTDDTLMEESGKMIFLIELLRRLRDEGHQTLVFSQSRQILNIIERLLKNRHFKILRVDGTVTHLVEREKRIHLFQQNKDYSVFLLTTQVGGVGLTLTAATRVVIFDPSWNPATDAQAVDRVYRIGQKENIVVYRLITCGTVEEKIYRRQVFKDSLIRQTTGDKKNPFRYFTKQELRELFTIEDFQNSATQLQLQSLHAAQRRSDKILDEHIAYLHSLGIAGISDHDLMYTRDLSVKEELDVIEESHYIQQRVQKAQFLVELESQNTELLVEKQRTGNEGTWLREPLFPSQTKKKCPEMNKPQPWPSSHLPTYHIQEEVISSQMASVIIDDLPKENENQDISNIKMNVTVLQDGSHSLVSTSDADSVAILPKGCGCVDEIWTNSSGMAIQKEALREGPTQGTLQKNPLGNFNYFLSESVRDDLGPNPDQLKDDETLPHCSPWPINPMTNENQNTESHASVIEIADEEWSASRSALQDAQVHEAKLEEEPLASSSQYACDFNLFLEDSADNEQNFSSQSLQHAENENSLCGPAANSKAESERGEVRLSLDLSETQDDPEVVIGNMKKGRRKARRILSDGENEDKTFQDTPGTNLFTSPCQFLPIKQFDASTPKSDISPPGRFFALKIPDSINKSVNARRSLASRRSLVNVVLDHVEDMEEGPDNSSKAEVAEDYLEEGAEESSGEVSEYTEDPPDETLPSEHKSSWLTTREPGALVQEASPGDPEPLLGRQLVDSPQDEAVEAVNDYEALVIRGKELKECGKIQEALNCLVKALDIKSADPEVMLMTLNLYKQLNKT
The following text describes a protein:
Function:
Catalyzes the conversion of coniferyl alcohol into coniferyl aldehyde in the eugenol degradation pathway. Specific for coniferyl alcohol; does not act on cinnamyl alcohol, 4-coumaryl alcohol or sinapyl alcohol.
Sequence:
MQLTNKKIVVTGVSSGIGAETARVLRSHGATVIGVDRNMPSLTLDAFVQADLSHPEGIDKAISQLPEKIDGLCNIAGVPGTADPQLVANVNYLGLKYLTEAVLSRIQPGGSIVNVSSVLGAEWPARLQLHKELGSVVGFSEGQAWLKQNPVAPEFCYQYFKEALIVWSQVQAQEWFMRTSVRMNCIAPGPVFTPILNEFVTMLGQERTQADAHRIKRPAYADEVAAVIAFMCAEESRWINGINIPVDGGLASTYV
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Sequence:
MLSSRVQSFLAFYALLDRLCCLPRTGWTLHPEIGCVESVADHSYATACVALDSSVSLDPQRRTRLVCMMLLHDLAESIVGDIIPESLSKVSAAEKRMQEASAMRELVLLLCNSGLHRMGALYKELFTMYEDAHSPLARAAHVIDKIDMLCQAHCYSARYNVNLERFFTNRIVETSGDPKDSDRSEKHFLCKLFSLYKGIHEQYSPPVCRP
The following text describes a protein:
Function:
Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.
Subcellular Localization:
Cytoplasm. Cell membrane. Membrane.
Sequence:
MLEWLKQIVRKDQQKTARPPNPVTSSKITSCSGTFSSSHQNYLVPKECSPPPHPNISWPEKCIRWSRLYDAYICHSERDSNYALALLRYLETQPEKLRCFLPMRDMSLGSPIPSEICSGLGNSHCWIMLLTPEFLSDDWCKFQMHQALIESPLSEGRLIPVMINLEMSQYPAELRFMHAIRSWSCDDSVFCKIRNSILSCKYIIALFQILVMNSN
The following text describes a protein:
Function:
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
Miscellaneous:
MISCELLANEOUS: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDATIRHDHKFALETLPVSLEDEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELKNNWNAAYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQNFAMRYVLIDGQGNFGSVDGLAAAAMRYTEIRMAKISHEMLADIEEETVNFGPNYDGSEHEPLVLPTRFPTLLVNGSSGIAVGMATNIPPHNLSDTVNACLRLLDAPDTEIDELIDIIQAPDFPTGATIYGLSGVREGYKTGRGRVVMRGKTHIEPIGRNGEREAIVIDEIPYQVNKAKLVEKIGDLVREKTLEGISELRDESDKSGMRVVIELKRNENAEVVLNQLYKLTPLQDSFGINMVVLVDGQPRLLNLKQILSEFLRHRREVVTRRTLFRLKKARHEGHIAEGKAVALSNIDEIIKLIKESPNAAEAKDKLLARPWRSSLVEEMLTRSGLDLEMMRPEGLAANIGLKEQGYYLSEIQADAILRMSLRNLTGLDQEEIVESYKNLMGKIIDFVDILSKPERITQIIRDELEEIKTNYGDERRSEINPFGGDIADEDLIPQREMVVTLTHGGYIKTQPTTDYQAQRRGGRGKQAAATKDEDFIETLFVANTHDYLMCFTNLGKCHWIKVYKLPEGGRNSRGRPINNVIQLEEGEKVSAILAVREFPEDQYVFFATAQGMVKKVQLSAFKNVRAQGIKAIALKEGDYLVGAAQTGGADDIMLFSNLGKAIRFNEYWEKSGNDEAEDADIETEISDGIEDETADSENALPSGKHGVRPSGRGSGGLRGMRLPADGKIVSLITFAPETEESGLQVLTATANGYGKRTPIADYSRKNKGGQGNIAINTGERNGDLVAATLVGETDDLMLITSGGVLIRTKVEQIRETGRAAAGVKLINLDEGETLVSLERVAEDESELSDASVISNVTEPEVEN
The following text describes a protein:
Function:
DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
Subcellular Localization:
Nucleus.
Sequence:
MIPQGSKNSRRKPDSTDKLTDGLFSGVLAIFIETGVSRKRLQVWQRRFEDLGGTILTAAANLLGRVDQIIILAAHEAALSKGINFDRLGSCPNLNFVQFRWVEECLKDGTLLSYEPFLLSASQDEHILSTDDSRLDAQSGPQSDQLYVTPALAIVPDGDLRACSEVVNEKRYDEVSEECTIDTKFKAICEDDMPDYNKHISRPLLELSEIYSDVLADEWRSLTYRKVANKLDRLPYQILSADEVKNIQGIGKSMVDKIKEILCTGQLQKLFNLKASSQVQIMQQFASVWGIGPKHALKLYQAGHRSLQDISEDQTLSPMARVGLKYHYDIALRIPQSEVSEAGSFVRHVLEDLCPGASIIVGGSYRRGNATCGDIDLLITHPDGHSHKGLLGRLVTKLEEAQFLITCPNPFTENITHKVNTYMGICKLPQYTHHRRIDIKIYPKQAYAFALVYFTGNDVLNRRIRYLAKKKGYKLSDQGLFLRVGDNKTGMASEVSIPCETEEEVFQKLGLPYPEPHERNW