The following text describes a protein:
Function:
Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSRKALGSRLSSAHKLQRNWNDWQPRSDSLSASQDGVKCSVSRDRGSEVLFEILPSDRPGTPPLHNDAFTATDALEEGGGYDADGGLSENAYGWKSLGQELRINDVTTDITTFQHGNRALATKDMRKSQDRPLAHSEESRLANLLRRASREDDRERRLATMKQMKEFIVHSENKVVLVKQLDSILSTLNDILNESSKLLQELRQEAAWCLGLLCAALSYEAERIFKWMFLKFSVSTKDEVKLLYLVAVHKALETAGEKKAFSAVMQLVMSNLQSILENLDTPELLCQSVKCILLVARCYPHIFSTNFRDTVDILVGWHIDHTQKHSLTQQVSGWLQSLEQFWVADLAFSTTLLGQFLEDMEAYAEDLSHVVSGESGDEDIPPPTVSLPKLAALLRVFSTVVHSIGERFNPIRGPPITEAYVTDVLNRVLACVTTAKQVFFSEAVLTAGNECVCVLLVSIDLGGQLIDAVISYGLDQLNCCQNCGPEYSLSVLTLLTLVVDQINTKLPASFVEKLLAPKSHLLELRFHREREVMAAAHGVYHAVLSLKNIPILEAAYKLVLGEMGCALNSLLSPLGLPDACPHIQHPAFSQLNFSPERAEFVLIFNLSALTTIGNTKNSLIGMWALSPTVFALLSQNLVIVHSDLAVHHPAVQYAVLYTLYSHCTRHDHFISSSLSSSSPSLFDGAVISTVTTATKRHFSTLLNLLGMLLSKDHLNPEARRLLLTWSLEVALMMKKSETYAPLFSLPSFLKFCKGLLANSLNEDTTICLQACNSLQVLSSSLTMELLQRCVDVCRVQLVHSAVRVRQAFGKLLRSVPMHVALSAHSHSEIKEISLAIRRHMSKVPSNTFHPQDFSDLIGFILYGTVHRGGKEPWLERLYHSCQRLEKKDSAMVPRALLKTEAVLWQWAVWEAAQFTVLSKLRTPLGRAQDTFQTIEGMIRSLAAHSLNTEQELSQWSGGESDEGHHTNQLRLALLLQFLENLEKLMYNAYEGCASALTAPPKGIRTFFYTNRQTCQDWLTRIRLALMRVGLLSGQPAVTVRHGFDLLTEIKNSSTQGPEMEVPVTMLVEALCELRCPEAIQGLAAWSLANTGKSMGWLSSVALQAEGKFEKAALEYQEQLCAVTGMDCSIKVFDRSLLKLTGTNTSSPKHTSSGEGRKTVLLKSSECSPEVLNFLANKACECYVALSDWESVQEWQASMMNLKKNSSSSSVNLKTDFNYIRSMSRFEEGDFTECRAQLELLPGDDYGLLNSTTKDKIDLKRLLPAVLSPDPSELQKAIEVQLLRSAVGAISATNHEQDQKVASSDTLVKYLKQTGRICLGPLRLSTLTLSDSLPTLSTLQLHCANSLENSLCNQHPEDCLIPLFSEALTTCKQQDVQPWLHALRYTTFQREFFQKLKGSSSPVDSHLMELCLTAVKFARKQGNIALATRLLSLCSKPAMSDTEGQDLVQSFRQLSLEGTVGEKWGPELEIEKAKVLFAAGQSVSAMEMLSSCALSYCHSGKCELAACRSVLTLCKWLLADWKDLTPQLKMVVKKNSGSTSLSTLSKNISGLLELPLEDQGMPHITTETTVSVGVGEPDFVLGQLYQLSTTQAPEVAKSWAALASWAYRWGRKVVDNASQGEGVPLLLGEKKEIEELLPAGTSDEDKETIFGILGQAMCRPAGIQDEDMALQNEEDDEDDMVDVIGRQLLGACPWLSDVEDTVTDGLIGVWRRVVDRIFSLYRVSCRAYFTFLKLNAGQVPIDEDDPKLLLNNQNSKQSSDDVIVMATLRLLRLLVKHAGELREGLEHGLASTPTAPWRGIIPQLFSRLNHPEAYIRQSICSLLCRVAQDSPHLILYPAIVGSISLGGEAQTAGNKLPSSLPTLLGNMQGEGLCGGESETGSGPTSQESSRGEEMVMYSSEDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVGELRRVTLLWDELWLGVLQQQHMHVLRRIQQLEDEVKRVQNNNTLRKDEKVAIMREKHSALMKPVVFALDHVRSITAAPAETPHEEWFQETYGDAIHNALERLRSPLNPANPASSWVPFKQIMLSLQQRAQKRASYLLRLDEISPRLTAMANTEMALPGEVSATDAVTIQSVGNTITILPTKTKPKKLYFLGSDGRNYPYLFKGLEDLHLDERIMQFLSIVNTMFTKVNQQESPRFQARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAVVQAQKAQDSFQQPQNLPMVPRPSELYYSKISPALKAVGLSLDVSRRDWPLSVMRDVLRELMEATPPNLLAKELWCSCTTPSEWWSVTQTYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTHNIETALGVTGVEGIFRLSCEQVVQIMRRGRETLLTLLEAFVYDPLVDWTAGGEVGFAGAVYGGGGQQAENKQSKREMERDITRSLFSSRVAEIKVNWFKNRDEMTGVLPQLEEAVDEYLNLQEQLTQVEKVQGKLLEELEFLEGADTRADHPIHSLEHRYSEHTQLQSRQRTVQDAIQGKLSDLDQWISQYQAAFASLEATQLASLLQEISSPIDLGPPSYVPATSFLQNAGQAHLISQCEALEAEVSALLQQRRSQLRGCLEHLHSYATVALLYPRAVLHRHRAHTWKQWMEELVCDMTVDHCQTIYHQYEMQFAPQPPPATCQFLSSIEMALQHHAAETNTRLLRQVERLKAEGASVPVCEEQLQEIERCIKVFLHEDAELGSFSLAGIIVSALCSLTRRNLVMEGAAASAGEQLVELTSRDGAWFLEELCSMSGNITCLVQLLQQCQLLSHDLDIPSPAETSQVVYLTNGVYTCLQELNTNFRQIIFPEALRCMLKGENTLETMLAELDALIDQCADGVSLQGLGEILMAHIRNASMGLEEDPDDHYLDVTRVLRAQYSELIQPRSMESSVQETPKMSAGQMLLVAFDGMFAQLETAFGLLIDKLNSMDVPAAWRKVDVIRESRATQAHFFDNVQTRQVLEEIFFLKRLQTIRDFFRLCGSFAQTLSGTCPTPTDDPPPSNGPVPIVKPLYRGSTVVSEDQMTRPIKAFTADFVRQMLMGLPTQALGLAICSSLSALGMDLIAQVEAKDFGAEGKVSLDDLCKKAVEQGVQAGRLSQLLLNRATVLASSYDTAWKKLDLVRRLEVSIEACKVSLQRNQLHIAMFQWQHEDILGARTQPMTVSPPPRSIILSNMKKKLYKLSQDDASIGSVQEKLASLEGSIEQRLKWAGGANPALAPVLQDFEATIAERRALVIKESQRANQVTFLCSTILNFEGLRTRTPEALNMDAALFELVKRCQATCSYAAQFNTSVSSLELQLLHRLSPAMDMSIGGPEWLVYAQNHLTQEMSSQRAMQEEREQQLESVTETLQLLVDSIKGTLSNHNRQLADVKHLLRAMAKDEENALAEGEEVTYDGSVRQFLSEYKAWQDNVQIVLFTVVQATGQPRSQEQIELLQEIPATLKELKVQSHSIYNGLVGFASPLVTERGSDCISPTSTVQTSFAAAVRCSGVKTQPDSMSQNARKALPRNFGTPADTPPSTLMINSKGLAPSPKRAVRDPKTGRAVQERNSYAVSVWKRVKAKLEGRDVDPNRRMSVTEQVDYVIKEATNVDNLAQLYEGWTAWV