lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MASSRMYLLVKCMLILQLMVLIAKNSRALICLPCDKSKCEEPKPCTGSVVLGICGCCSVCAKQKNESCGGVYGLYGTCDRGLRCVIRPPLNGGSITQYEVGNCEDENWDDDQLLGFEPCNENLVTGCNIIDGKCECDSVRTCNNPFEFASQEACQTALQKIEEERPDCSKARCEVQFSPRCPEDSILIEGYAPPGECCPLPSRCVCSPAGCLRKVCQPGHLNILVSKSSGKPGECCDLYECKPVFSVDCSTVECPPVKPVQCPADSYETQVRLTADGCCTLPTRCECLPGLCTFPQCSAGMSPQVMSRGDGTPGRCCDVFECVNETKPACTLNGVEYHDGDMFRMDACRFCRCQGGVSVCFTAQCGVLHCERYYVPDGECCPVCEDPIYPVLSLAGCYVNGQILAHGDHWREDDCTFCQCVSGDARCVAAACGHSCLNPVTVPGECCPVCEEPTYITMAPPACGSLDNCTLLEQSCAFGFRLDPSGCRTCACKSREELCGGLMASCTLKCPFGFQTDIHGCDVCQCRPRHKKCKAVACAKDCPFGYIKNKHGCDTCRCKKCPELPCDKACPMGFQHDELGCLICQCRDQSSSSVTPAVKLGSCLSMDGRRHENGQSWHDGCRDCYCHAGREMCALISCPVPPCDNPTIRPGHCCPTCPEESSSHKPELSEASVCLAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCHSPIRTQDSCCPHCPDDPVTPQTPSNDSMPSYCRNEDGDIFLAAESWKPNVCSSCVCLDGAISCFSESCPPVNCARPVLRKGQCCPYCLDATPRAVCHFNGKTYMDEERWDIDSCTHCYCLQGQTLCSTVSCPALPCHQPLTVEGSCCPMCPESYAPTNVPIEKTDQRGDKSRHQPAWPTHSENDVMPQFRGEFGSLQMPYLDGKTPLPSEDAGLHWAWVALPVLMMMLTLAALLLVNQRKQWIPVPCYRTPNKSTCLNNQLVYVDCQKGTKVQVDSSQRMLRIADPDSRYSGYYSMQKHNNLQADNFYQTA
The following text describes a protein:
Function:
Involved in double-strand break (DSB) formation during meiotic recombination through stabilization of SPO11 association with meiotic chromosome and helping SPO11 to recruit other DSB proteins like REC102 and REC104 to meiotic chromosomes. Also a component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for controlling the propagation of M double-stranded RNA (dsRNA) and thus for preventing virus-induced cytopathology.
Miscellaneous:
MISCELLANEOUS: Present with 1710 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome. Note=Relocalizes from the cytoplasm to the nucleus and is recruited to chromosomes by SPO11 during meiotic prophase.
Sequence:
MSKVFIATANAGKAHDADIFSVSACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDVLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKWGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDIEIEEDILAVDEHGDSLAEPGVFDVKFLKKGWRSGMGADLNESLCCVCLDRSIRWFREAGGK
The following text describes a protein:
Function:
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
Sequence:
MFKRTVILLAGPTGSGKTAVSLKLAPLVDGEIISVDSMQVYQGMDIGTAKVSLTDRKEVPHHLIDVCHVQESFNAVDFYYHAVQACQDILSRNKVPILVGGTGFYFHTFLSGPPSGPSPDFVLREQLTLEAQERGISALYQELELLDPVYAATITKHDKNKIIRALEIIRKTGSKVSSYAWQSTVNESKEYHCRRWLLSPDPELLRHNILERCDQMLEEGLLDEVQALLAAGIKGNSSASRAIGYREWIEFLDLGSPPDLFEITKQKFITNTWRYTKKQRTWFKRYSLFRELRPMGMTLDDMAKKIAQDYFLCG
The following text describes a protein:
Function:
Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.
Subcellular Localization:
Cytoplasm.
Sequence:
MGDSLTECMEIFSQDGVQLKTAQASFVNYLNLVGTLYITEYANSNCRRCLEWKPNDVTVDSDVQDQEWAVVNTVQKRSRTYSESLPPDSTIKPKLLKVNFVDIKSFKTSNKNRQLTLFDGKSEIMCCFMFQHGNCDYLITVLRGMLKTIPAKRDKHLFIVIHDESLEAAQLDKSFAELNIFQDPPPTLWKLVKSFHDRPYETTLETFAKVTDYVYRSPEQRDIDDDQRELLHRSLTEYASSHSQGDYEVIAKVPELPERKDYPRGRPLSAEQWKNLQNHEGKIEDVEQIKLMIFRGGVAPNLRYEVWKYLLDYFPWNSTQAERQKLLCEKNDEYYNMKLQWKRMTKVQEDNFSDYRERKNLIEKDVNRTDRTMDFYAGDNNPNLQLLYDILMTYIMYNFDLGYVQGMSDLLSPILHLLKNEVDAFWCFVGFMNKISSNFDIDQAGMKEQLQNLHTLLGFIEPQLVNYLDKHDSGNMFFCFRWLLVWFKRELSYDDVMRLWEVLWTGLPCENFHLLVCVAILETEKQALMENNYGFTEILKHINDLCGKLDVAAVLVKAEGIFHQIKEAEHLTDNIRMILGLPLVGVQQCPEEILSTSPDSPDEDLYERVYDSMQHVMT
The following text describes a protein:
Function:
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
Domain:
The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MIINNVLWLTILSLGTVPVQAQSKQKPLSTPDRNNNNNNNNQMADYNRPSSGGWKPVLDPTDNKTIIGHHWRRHDYVPGEEALALQTLDMWIPISPAALSWGKPTPNTLLGDGAKAPWLIYIHGGAWRDPAIDSSSFDASATKILSDLAQQPLEQRKKTVAGIASINYRLSPHPNHPSSDPYDPNRTAKHPDHVADVLTALGFLKNYFGMKEYVLAGHSCGATLALQACMSPERWGLAGTAEWRAGWYNVAKPKAVVGFNGLYDLAGFIADPPKGYERWKEAYREFVVGAFGKKEEDWKKVCPGSIAEGWVREWNLTQQQQQGEEWKKRKVVLVQSLEDSLVPVEQTEGMAEYLERENQKVADEDKKVEVVVLREEKGGDHDEVWKKGERLGEILLGVLNGEI
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MEASDWTYRGEGAVNLVLAYNGTRSDLVGKILRIQKVPRNESECGHDYSGLNKQECLLWEEFTEIVSAPTREIVQHYFVQHVMCPLLGSRHVDAGTSIHVTPEFLEAVENNVLQQRPAWRVDATKVNPLCDSVMLMSDLSVFPLDTTSSEVGEAFENLLKNVIQAQEGMRTHYFLELISKTVCSSGLLDRLLEVQKLDTTDIEGAIHAYYNIISQPCMVCGQLDKDQSTKRYNSLHSISMEESLKIVRDYLIAATAKDLSMIISFRPREAGNVESPYNIVSLESTNQSFDYKASFIDLDLKPLKRMEYYYKLDQQIVNCYVQMVKSKHQLDHSGSTVGA
The following text describes a protein:
Function:
Involved in the lipid remodeling steps of GPI-anchor maturation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRKRRERIARMKHCSILSLVPLLAGVLCSIGDRLGEFVECNRVCRVRRGCEQHGGEGAFPDDSPFAAYTFVDTPAAYRALLWDCSADCDYQCQQAITHQRLLAGEPPVQFHGKWPFVRMLGMQEFFASLFSVANFVPHLQGYRQLRRELARAPSVGGSSVLLRKYQSLAVVGMLAWISSAVFHARDMPLTEKLDYFFAGATVLAGFHALYIRVRRLDLAPTRRRCFSLAVLLVFVLHIVRLYRNWNYTYNMRFNICFGLLQYLLLLLQALQNFGSLRRQRQKAGLGLYAQQPGMQFQLVLVPVLLVLYTGLAMSSELFDFFSYHWQIDSHALWHFLTVAPSFMLYDFFLKDYRYLNTLSSHSAPE
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for glutamine; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MVDQDRVRPAVVEVGDGAAIPSKSDIGLFTAWRIAFVGAIGILVVLTITKPDPYLNILKFVPDGILVTFQVTVGAILLALVIGLVAGLGRISSNRIINGIASLYVEIIRGIPLLVQLFYIYYALGRFVHVPDMASAIIAMAVCYGAYMGEVIRAGIQSIPKGQMEAARSLGMTKGQAMRHVILPQAAKVVLPPIGNEFIALLKDSSLVSILAVADILRRGREFASESFTYFETYTVIALVYLIITLFLSKLIGIMEERISAGS
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MAAAARLLARISRQGVASAAVAGVVRRRPEAASLLGASALAAAAEPCASIKVIPLLNQPARYSTSAFQRFGFSTSAPQQDDKEANKHADDGVNKTAGASTEASDSEDLDLSKEDLVKLLLEKDESLKSKDQEVKDMKDKVLRSYAEMENVLARTKRESENTKKYAIQNFSKSLLDVADNLSRASSVVKESFSKIDTSNNSDEAVPLLKTLLEGVEMTEKQLGEVFKKFGVEKFDPLNEKFDPNRHYALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGVTEGGPVEEEPEEKSSKSE
The following text describes a protein:
Function:
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus, Golgi stack membrane.
Sequence:
MIMPPSTRHAPPSPSLPPKRVSVLPPSVPSLASLSTRLTIHGARLGDSPSGTKTGSAALWCSARLGAPGGGLWDGDHDAWAQDDVHVTQGQDPEDMKQFIFVYYELGNFYQNHRSLVDNNNLSGPLPPELVDTLPPELVDTRSLLAILAGFAIGSGALVVPGVVWCLRWQSWSEGCRCSLPKVFIGLIVGAMFSYWFSAMTMKSVGSVALKMVEEVRRQFNTILGLMEGTGKPDYATYVKICTDASINEMIPRGALVMLTPSLLEPLWHRDSLWRSCWCPDFWSVDVTEPLLVEVDQICHLACPASPIFYKHNSVKTIKTNVIGTLNMLGLAKRVGARILLTSTSEVYGDPLEHPQIEAYWGNVNPIGVRSCYDEGKRVAEMLMFDYHRQHGIEIRIARIFNTYGPRMNIDDGRVVSNFIAQAVR
The following text describes a protein:
Function:
Involved in splicing of intron aI5-beta of the mitochondrial COX1 transcript.
Miscellaneous:
MISCELLANEOUS: Present with 861 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MGLPEVNFLRKNCILVELKLFYQTVYPPKELYWNNRITAELSTFSNIKYARPTFAVNNGTFQRTRPKLDLVLASSDIRKLATVLFNLKALIMNTKGEEPTLTTMTSVQTNEEKNDNLEQKYSSLLDRWNGKVEVHDSPFLQLQRDSNLLFAERPVRYVSTTEGEGVDISSEEFFRLEEEQCRRNYDVLVDEHSTPSVGMKDGQYGPNIIHFEPSLYHTYSSLPMSMKFWLNGLEDDETTMMNIDEKSAENLDILLHGFKGFSNKRVKG
The following text describes a protein:
Function:
Involved in the organization and/or function of the actin cytoskeleton.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MFNNGDNMSRERFSSNHSMQRQKTESRANFSRRLVPSDSNRKPVPNGASNSPLSRDAASHLISTIETSIMKLLVVTKELLESLTNWSKGTVNDSAVSSVYVTLIGEFLQTTKSFHEAGIETADLNDFPLELRSVLEQTLEKTPSSDALETNLPNVRELVMHLLQSLKYKQSLVKSRLNQSRSNLPQMTREANDNDVNRRNSRGSSQGSISSFRNPDSRKQYEETTSASLSAPGAFDALKQTNALERRASKRLSHMVKDQQNNEGSSQNLRNITVESVRGFLRDSSKPDNIMDSPSPKVSKRPSIVRQDSHDSNKLSRRPTINTSFDRKFSPKLTRTPSLTKSLDPGTPTSLKSPSLRKSPSSFVQKDVYSRSNSLRISQANRSNVFPGATDVTRSVSDHRILSSSTINDGEVAPPLPQRSRTISSPNSPLSATVLPSSTPILLPRGRSSTLSVNKKQFNADDGSTLNSPNSIRETEEYAASPKLEDIADEVETDATSQRELLERQIQKAESSEDTSEIESLQGKLSLPQVSSTQQEIQPSSSVPEAASNEIAEKEPAVTAIESITERKEEAPVISSSEKIESGTSISTSDTKGGLANFENDSLEELERLIQQNNAEQDEPSYKFHKYEYSSEESGSEDEFKSEKDTKGYVISNDDSTQVEEDSEDKSTPNTGASAKLINDPSSTITVSDVYPKKPASPVEITEPPSSALVSATSPTTNVPIVPEAVHLSTAFSTAPVSTIVSNISPLPTVAPPNVSGSPSETPISKPEKVPVVSQTEKALPKPLGVDTEKYYFLRYNNQTRKVKVESPLSNANELGELFSNVYKISFSGDSYELNIEDPDTKISYLLEDLSDLKYKSLVSFMFKEQDANKKREDFHSGEVSAIQHSSAQNTLDDHVNTTTHESPSSAFTEILERLKAIEQNISTNHTNDSAALKSSEDHSKLANNFSVPDSIDHKFYQQVKNMQLELASLKQISAAFFTRIPLKIKDFKKEINAFNEKGSLDFQFGRGFVLSSKDRIEREVKNVVEKFDEVNDQIELMRSDVLLRKVRPGLDQTSQLNEESAYLEKRIQTLERSLEEVTPIWKKQWERELNAIVQEQEFLDSHTVLISDLKRDLSALSTVLSNVSAIAELQAKSSIKSKPLTLKTATESEIKGYRDQIQLEVLNLKPDSEARLQAIERSELLQKKRLLQRVDEFSKEVKTFVENEKLNKIGGAEEADRIRTIQDEKVRKILWDDFVSSKRNGKNGGSFIEESSDTVLDEHVVPDNSAKATVAEIDYGSQVDTENFMLERSPLATPKPLKQPDFNIYETPIVRSTAHETDDEQTPSKYSDNRVESSSDTVFENTDLKYDNNVQMSKVTHHVRHDTISTDDYDAYEDAEDVEETSLT
The following text describes a protein:
Function:
Acts as an assembly factor of mitochondrial complex I.
Subcellular Localization:
Mitochondrion.
Sequence:
MIPTPVLRFNPIADKVPKWKRIYHKWRGIQNMPFKSKYFVGYDLDGNSYWEFKNVNNPGRYRRIVEPAKPDLSLVDHKIPPQWVQWLRFTRPHHPTLEELIADKQRQELLQAKIAAYEAKWKEIPLKTAENADESRDMSLEDQLKPTFTEAELAEMAQVFEKVPQQAAPAPPRVPNMAAIEVEDIIKHYPENGPDTVLADGGRQRDHDLKMDYVEKERDDSGKPAEWTPKAAVRRRG
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MKNIFRRSVQIFHKDKKEGDKQDYTGSSGSSGNSGTDRSPTSSLSKKDKKHSKHHQNESYSGDNSPTLSRNHHDEIGHLQYTANHHIATSHHSHSHNHNHNHNHQLTQPIQQQQQTQHVNLASNNYYIRHIYTNNQYDETTQIVMNNGIPFIYNPNARKIFGVPLTQVPCRAGSNVPIIIEKLIDHIERTSLNSEGLFRIPGVDLTINQYIKLFDNGEDVDVSPIEPYTAAGLLKRFFRDLPVFVPQSINKRVVSLFIDEEGKKKPVDMEILSNLRVLVHQLPTVHFEVMQELTNLLGKLMSRSDQNKMTISNIAICLVPTLNCVPAIVTYSIQMHDFFYNEVFPQHHLYYMRPYEEKLVESAPTQPINIMTTSGGEKRYSSRPASITISGLLPSNGQNNSPSSSTITSTTITSPHDSTAPITFTVTTTFSPEQQQQMLQQQQQQQQQQEKQSSSSLSQSQQSIQPISDTNSTKSDRRTFRVDPNLDLTQYIEDTQYNVNRNYLYNGGPSGTTGTTPNGGSLSIGGGNGGNGGSSLSVGSGGGNGGSSLSVGSNTSVGVGGGGGGNNTTDQSKIYRRSVAYTNNEDTKAAIQQIKEKIDRYSKEKKTREEKEREKLLRYSIDLERYKDRTINNKQEKRASRDINKEIEREIEKKRLSPRERLNLFGLSSSSSSVNSTLTRSTANIISTIDGSGGSNRNSKNYGNGSSSSSNRRYSNTINQQLQMQLQQLQIQQQQYQQTQQSQIPLQYQQQQQQQQQQTTTTTTTSSGSNRFSSNRYKPVDLTQSSSNFRYSREIYDDDYYSNNNLMMFGNEQPNQTPISVSSSSAFTRQRSQSCFEPENLVLLQQQYQQYQQQQQQQQQIPFQANPQYSNAVIEQKLDQIRDTINNLHRDNRVSRDYTHYLREVEDLRSSLQKETVVSNEFIKNIELEDKLRREEEKNQRLIEEIHLLETYFILKEKSKAKRLSTTKDLLTRSRSPTLPSSINMSTSSLGSSSSSAYNNNNNNNNVPK
The following text describes a protein:
Function:
Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin. Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation.
Subcellular Localization:
Nucleus. Cytoplasm. Chromosome. Note=In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions. Localizes to chromatin.
Sequence:
MWSEGRYDYDRLPRERVPPRSHPSDGYHRVVNVVPKRPPLLDKRPPLLDKRPPLLARPDEGGYSRYYSHVDCRVCDEGRSFSHDRRSGPSHSGDESGYRWLRDDHSTSRQPDYRDMRDGFRRKSFYSSHYSRDRSPHKRDAPFFRESPVGRKDSPHSRSGSSVSSRSYSPERSRTHSFHQSQHRKSSRVGASYKRQNEAIRGRGKERSIQSVKTSRDASPSSSSAVASSKALDKPSRLTEKELAEAESKWANETLEKSDESNLAEMNEFEAGSTAPLFIDQTEEPESNTVDGTELYEDSQLSNRSKAIASKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSVQFALRQNLHEIGERCVEELKRFITEYDNSARDFGDPF
The following text describes a protein:
Function:
Terpene cyclase; part of the gene cluster that mediates the biosynthesis of novofumigatonin, a heavily oxygenated meroterpenoid containing a unique orthoester moiety. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase nvfA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations. DMOA is then converted to farnesyl-DMOA by the farnesyltransferase nvfB. Epoxydation by FAD-dependent monooxygenase nvfK, followed by a protonation-initiated cyclization catalyzed by the terpene cyclase nvfL leads to the production of asnavolin H. The short chain dehydrogenase nvfC then as a 3-OH dehydrogenase of asnovolin H to yield chemesin D. There are two branches to synthesize asnovolin A from chemesin D. In one branch, chemesin D undergoes Baeyer-Villiger oxidation by nvfH, methylation by nvfJ, and enoyl reduction by the nvfM D enoylreductase that reduces the double bond between C-5'and C-6', to form respectively asnovolin I, asnovolin K, and asnovolin A. In the other branch, the methylation precedes the Baeyer-Villiger oxidation and the enoyl reduction to yield asnovolin A via the asnovolin J intermediate. Asnovolin A is further converted to fumigatonoid A by the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfI that catalyzes an endoperoxidation reaction. The alpha/beta hydrolase nvfD then acts as an epimerase that converts fumigatonoid A to its C-5' epimer, which then undergoes spontaneous or nvfD-catalyzed lactonization. The following step utilizes the ketoreductase nvfG to produce fumigatonoid B. The dioxygenase nvfE further converts fumigatonoid B into fumigatonoid C. Finally the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfF catalyzes two rounds of oxidation to transform fumigatonoid C into the end product, novofumigatonin A.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDPWIALSSPLTSQTVEYVANTLRIMCAISWNISYMSMAYYSFRDKTYGNALIPLCNNIAWEFVYSFIHCPKLTFVRIENTGWFLLNIVVMYAAIKYSENEWKHAPLVQRNLPFIFAVGISAMIAGHLALAAQIGPRIAFVWSAKGCQLVLSTGALSQLLSRGSTRGGSYVVWLSRYLGTVFIDVMVTIRHVYRAAGPSWPSSPLLLWFMAVFHLLDWTYGFCFYHIRRQELVSEAAEKDKDK
The following text describes a protein:
Function:
Forms the helical nucleocapsid (NC) with 12.71 N subunits per helical turn and a rise of 5.3 Angstrom per N subunit, protecting the genome from nucleases. The encapsidated genomic RNA serves as template for transcription and replication; encapsidation by N is coupled to RNA synthesis (By similarity). Forms the encapsidation complex with the phosphoprotein protein P. Before encapsidation, the newly synthesized free N protein, so-called N0, is chaperoned by P (By similarity).
Subcellular Localization:
Virion. Host cytoplasm. Note=Found in cytoplasmic viral factories.
Domain:
Ncore is globular and carries the regions required for self-assembly and RNA-binding. Ntail is an intrinsically disordered monomeric domain in the C-terminus.
Sequence:
MSSVLKAFERFTIEQELQDRGEEGSIPPETLKSAVKVFVINTPNPTTRYQMLNFCLRIICSQNARASHRVGALITLFSLPSAGMQNHIRLADRSPEAQIERCEIDGFEPGTYRLIPNARANLTANEIAAYALLADDLPPTINNGTPYVHADVEGQPCDEIEQFLDRCYSVLIQAWVMVCKCMTAYDQPAGSADRRFAKYQQQGRLEARYMLQPEAQRLIQTAIRKSLVVRQYLTFELQLARRQGLLSNRYYAMVGDIGKYIENSGLTAFFLTLKYALGTKWSPLSLAAFTGELTKLRSLMMLYRDLGEQARYLALLEAPQIMDFAPGGYPLIFSYAMGVGTVLDVQMRNYTYARPFLNGYYFQIGVETARRQQGTVDNRVADDLGLTPEQRTEVTQLVDRLARGRGAGIPGGPVNPFVPPVQQQQPAAVYEDIPALEESDDDGDEDGGAGFQNGAQAPAVRQGGQNDFRAQPLQDPIQAQLFMPLYPQVSNIPNHQNHQINRIGGMEHQDLLRYNENGDSQQDARGEHGNTFPNNPNQNAQSQVGDWDE
The following text describes a protein:
Function:
Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MELSLESLGGLHSVAHAQAGELLSPGHARSAAAQHRGLVAPGRPGLVAGMASLLDGGGGGGGGGAGGAGGAGSAGGGADFRGELAGPLHPAMGMACEAPGLGGTYTTLTPLQHLPPLAAVADKFHQHAAAAAVAGAHGGHPHAHPHPAAAPPPPPPPQRLAASVSGSFTLMRDERAALASVGHLYGPYGKELPAMGSPLSPLPNALPPALHGAPQPPPPPPPPPLAAYGPPGHLAGDKLLPPAAFEPHAALLGRAEDALARGLPGGGGGTGSGGAGSGSAAGLLAPLGGLAAAGAHGPHGGGGGPGGSGGGPSAGAAAEEINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEQQKERALQPKKQRLVFTDLQRRTLIAIFKENKRPSKEMQVTISQQLGLELNTVSNFFMNARRRCMNRWAEEPSTAPGGPAGATATFSKA
The following text describes a protein:
Function:
Potential transporter for phosphate.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDALAIAIVAVAFYIAWNIGSNDSANAMGTAVGAGILSFRQATLTIAIFTLLGAYLKGYKVMKTVGKGIVPEGYLTMEMALIALLSAGVWVTIATIKGLPVSTTQAIVGGVIGVGLATSAPVNWWTLTKIAAAWVASPVLSGILAIILYKFYSYVISKIKSVSTIEALYKALAILGGSYMAFNFGTNEVANASGPIVGAGFMAPKTAGVLVALSLAVGALTFSYAVMHTVGKKITALGPVSAFAAQFGSAMAVSIANVFGLPVSSSQSIVGGVVGVGLLAGRGVDRKVIVDIVFGWVATPLTAIGISFVLLKLFALAGMV
The following text describes a protein:
Function:
RNA-dependent RNA polymerase which replicates the viral genome composed of 3 RNA segments, RNA1, RNA2 and RNA3.
Sequence:
MSSKTWDDDFVRQVPSFQWIIDQSLEDEVEAASLQVQEPADGVAIDGSLASFKLAIAPLEIGGVFDPPFDRVRWGSICDTVQQMVQQFTDRPLIPQAEMARMLYLDIPGSFVLEDEIDDWYPEDTSDGYGVSFAADEDHASDLKLASDSSNCEIEEVRVTGDTPKELTLGDRYMGIDEEFQTTNTDYDITLQIMNPIEHRVSRVIDTHCHPDNPDISTGPIYMERVSLARTEATSHSILPTHAYFDDSYHQALVENGDYSMDFDRIRLKQSDVDWYRDPDKYFQPKMNIGSAQRRVGTQKEVLTALKKRNADVPEMGDAINMKDTAKAIAKRFRSTFLNVDGEDCLRASMDVMTKCLEYHKKWGKHMDLQGVNVAAETDLCRYQHMLKSDVKPVVTDTLHLERAVAATITFHSKGVTSNFSPFFTACFEKLSLALKSRFIVPIGKISSLELKNVRLNNRYFLEADLSKFDKSQGELHLEFQREILLALGFPAPLTNWWSDFHRDSYLSDPHAKVGMSVSFQRRTGDAFTYFGNTLVTMAMIAYASDLSDCDCAIFSGDDSLIISKVKPVLDTDMFTSLFNMEIKVMDPSVPYVCSKFLVETEMGNLVSVPDPLREIQRLAKRKILRDEQMLRAHFVSFCDRMKFINQLDEKMITTLCHFVYLKYGKEKPWIFEEVRAALAAFSLYSENFLRFSDCYCTEGIRVYQMSDPVCKFKRTTEERKTDGDWFHNWKNPKFPGVLDKVYRTIGIYSSDCSTKELPVKRIGRLHEALERESLKLANDRRTTQRLKKKVDDYATGRGGLTSVDALLVKSHCETFKPSDLR
The following text describes a protein:
Function:
Activates transcription of the cmpABCD operon under carbon dioxide-limited conditions. Specifically binds to the cmpR-cmpA intergenic region.
Subcellular Localization:
Cytoplasm.
Sequence:
MKNATLHQFEVFAAIARTGSFTKAAEELFLTQPTVSQQMKQLTKAIGVPLYEQIGRKIYLTEAGQAVLDASKNITSCLDQLQEVIADLQGLKKGNLRLATITTGKYFVPRLLGEFRQQYPGISISLQIGNRQQILERLANNLDDLYFLGKPPSNLDINIRHFLENPLVVIASRQHPLVKEKKISLERLVNEPLIMRESGSGTRMAVEEFFSENRLKMNVEMEISSNEAIKQAVYGGLGISILSLYSLALEGINGPLAVLDVEGFPLQKHWYIIYQKSKQLSIVAQTFLDYLFAHDEAVSIAQIF
The following text describes a protein:
Function:
Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The DNA-protein cross-link is then reversed: able to catalyze the reversal of the thiazolidine cross-link and cycle between a cross-link and a non-cross-linked state depending on DNA context: mediates self-reversal of the thiazolidine cross-link in double stranded DNA. May act as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity).
Miscellaneous:
MISCELLANEOUS: The thiol group of the catalytic Cys-2 is deprotonated by its alpha-amino group to form a thiolate anion that is poised for catalysis. The abasic site sugar moiety is in equilibrium between its cyclic furanose and open-chain aldehyde forms. The Cys-2 thiolate anion attacks the abasic site C1' position to form a covalent bond. The Cys-2 alpha-amino group proton then transfers to the oxygen which is stabilized by the Asn-75 side chain. The O4' rotates to a new position and interacts with the His-160 side chain. The Cys-2 alpha-amino group then attacks the C1' position and transfers a proton to the hydroxyl group to release a water molecule, meanwhile forming a covalent bond with the C1' atom. Thus, a thiazolidine linkage is formed between the abasic site C1' atom and the Cys-2 amino and thiol groups. The Glu-105 side chain carboxyl stabilizes the thiazolidine linkage via a strong hydrogen bond with its amine group.
Domain:
The N-terminal catalytic Cys-2 residue forms a thiazolidine linkage to a ring-opened DNA abasic site. Glu-105 catalyzes reversal of the thiazolidine linkage; self-reversal is favoured by duplex DNA formation (By similarity). Glu-105 is also involved in sensing abasic sites in single-stranded DNA (ssDNA). His-160 stabilizes the abasic sites by forming a hydrogen bond with the O4' hydroxyl group.
Sequence:
MCGRFAQSQTREDYLALLAEDIERDIPYDPEPIGRYNVAPGTKVLLLSERDEHLHLDPVFWGYAPGWWDKPPLINARVETAATSRMFKPLWQHGRAICFADGWFEWKKEGDKKQPFFIYRADGQPIFMAAIGSTPFERGDEAEGFLIVTAAADQGLVDIHDRRPLVLSPEAAREWMRQEISGKEASEIAASGCVPANQFSWHPVSRAVGNVKNQGAELIQPV
The following text describes a protein:
Function:
Involved in a key methylation step in both tocopherols (vitamin E) and plastoquinone synthesis. Catalyzes the conversion of 2-methyl-6-phytyl-1,4-hydroquinone (MPBQ) to 2,3-dimethyl-6-phytyl-1,4-hydroquinone (DMPQ, a substrate for tocopherol cyclase), and 2-methyl-6-solanyl-1,4-benzoquinone (MSBQ) to plastoquinone.
Subcellular Localization:
Plastid, chloroplast inner membrane; Single-pass membrane protein. Note=The transmembrane domain is sufficient to direct stop-transfer insertion and topology in the inner envelope membrane.
Sequence:
MASLMLNGAITFPKGLGSPGSNLHARSIPRPTLLSVTRTSTPRLSVATRCSSSSVSSSRPSAQPRFIQHKKEAYWFYRFLSIVYDHVINPGHWTEDMRDDALEPADLSHPDMRVVDVGGGTGFTTLGIVKTVKAKNVTILDQSPHQLAKAKQKEPLKECKIVEGDAEDLPFPTDYADRYVSAGSIEYWPDPQRGIREAYRVLKIGGKACLIGPVYPTFWLSRFFSDVWMLFPKEEEYIEWFKNAGFKDVQLKRIGPKWYRGVRRHGLIMGCSVTGVKPASGDSPLQLGPKEEDVEKPVNNPFSFLGRFLLGTLAAAWFVLIPIYMWIKDQIVPKDQPI