lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
IFVESLAMGYKMKLGCSFLLMFIFSLLSTGRTDLGKNITVAVMLPDNYSKYAWALPRVFPAIRMANEEIQKNGGLLRGYHLNLMNTSTEDEGGGCSETLSQIVAVDIKLYNNPDVFFGPGCVYSVASVGRFATHWKIPLITAWAPAFGFDQKDQFKTVVRTGPSTTKLGEFVYNFHSYFNWTSRVVMIYHDLRKDDRPYYFLSEGIYSMLKNANVTIFPHPYSETQIYDYKEIITFIKDNGRIVYICGPLETFLEIMNQFQKEKLNHEDYAIFYLDVFAESLKAKKPWHNKEITDGTDTMKIFQSVFIITFREPDHPEYFKFQKELHIRAKQDFSVKLEPSLLDFIAGCFYDGFMLYAQALNETLTEGGSQKDGINITQKMQNQKFWGVTGLVITDENNDRNIDFNLWAMTNVETGQYGVVAHYNGTTKEIIWSSTEKIHWPKGSPPLDNPPCVFNMEDYCTNEGPLTVFRIVAFGSGLALIIFAISSFLIYRKLKLEKELASMLWRIRWEDLQFESPHKYHKSAGSRLTLSQRGSSYGSLITAHGKYQLFAKTGYFKGNLVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMTFLHNSHIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSVCDNDDSHALYAKKLWTAPEFLRYERVPPQGTQKGDVYSFGIILQEIALRNGPFYIEGMDLSPKEIVQKVRNGQKPYFRPTTDINFHSEELAILMEGCWAEDPADRPDFSHIKMFIMKLNKEGSTSILNNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIAGMALALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSSATKEVLDEFGYFDLQLRGDVEMKGKGKMRTYWLLGEKTDVYVI
The following text describes a protein:
Function:
Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling.
Sequence:
MRVPAAVTGGCGCGVDGGGGCCRGGGKLADWEEGKDDEMKSVVVKGWTRMAQVVPLHDNASAEDDDDDEEDDDEDDDDDDDEDDEEEAAPPYVMAVDDSSVDRAVITALLRRSKYRDSGKRALEILGSEPNVSMIITDYWMPEMTGYDLLKKIKESSELKQIPVVIMSSENVPTRISRCLEEGAEDFLLKPVRPADISRITSRMLQ
The following text describes a protein:
Function:
May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
Subcellular Localization:
Cytoplasm.
Sequence:
MADLIARLREDGIQKRVIQEGRGELPEFQDGTKATFHFRTLHSDPEGSVIDDSRARGKPMELIIGKKFKLPVWETIVRTMREGETAQFLCDVKHTVLYPLVAKSLRNIAEGKDPLEGQRHCCGIAQMHEHSSLGHADLDALQQNPQPLIFHIEMLKVESPGTYQQDPWAMTDEEKAKAVPLIHQEGNRLYREGQVKEAAAKYYDAIACLKNLQMKEQPGSPDWIQLDLQITPLLLNYCQCKLVAQEYYEVLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRALEARIRQKDEEDKARFRGIFSH
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNDTWRSRLKEISHITADPFLRDFHKLHTNDKEQIYSILHNPDNVVEQTFKNTIIKSMEESMFRPLIPTQQMKRRQNDHHNQGPPPKVQKSTVDSLKSQHQIDQQNLDWFLSQPLEDLEVMTVPEQYPLTVPAVLPLAELYYLTQTLASIKLLPGSHKVLMTENFESALAEGKIAVLYSRIEELKRQGKWSLRQPQKFYDPFKFIRKSKKKSFHWDYLLQEGKWMADDFRESSKYKKWCCVVIAEAVEQYWKGRKVSHQTFVDVADLKKIDKSIIRNLPVYTGLGGDSREPPIATVSKLVYPAEDNHWYKIALKPHHHHHRHQTTHQGLFGSTRKYNTLKPPKPPTPKNIEYRIPTIWLPEDDKRLIHYVAEFCFNWDLISEHISSSSTAVSLKKYESNIERRTPWQCFERYIQLNDKFQFSDMKGVYAYHAQQWLEQAHRAQSTTKRRISPLGVGPESVQRGNRKLRWASMFDAMRKAMKKREIAAAKVNHRKSTAELQANQNVTEPKPNSDRIPTPAELSRLKFERDKTLHENHINQQATRARMVQAVAKPAPAPAPAPPPPPPPKPVKRPTTPNGTPLTNEQIQHLLQMQKHRRMLQQQQQQQQQQQHQQQQRRIHFPPAQVSKVINDIQQQNPGLSKDQVTKLAAQYLASLSQQGYGVPSSPVPPHQKNQTASPMSGSPNNA
The following text describes a protein:
Function:
Plus-end directed kinesin-like motor enzyme that plays a critical role in the organization of phragmoplast microtubules during cytokinesis. Constitutes a signaling module in association with serine/threonine-protein kinase TIO that is required to support phragmoplast expansion and cell-plate growth in plant cells. Binds microtubules in an ATP-sensitive manner.
Subcellular Localization:
Cytoplasm, cytoskeleton, phragmoplast. Note=Localized to the midline of the nascent phragmoplast (late anaphase) and remains associated with the expanding phragmoplast ring.
Sequence:
MKKHFTLPRNAILRDGGEPHSPNPSISKSKPPRKLRSAKENAPPLDRNTSTPDHRSMRMKNPLPPRPPPSNPLKRKLSAETATESGFSDSGVKVIVRMKPLNKGEEGDMIVEKMSKDSLTVSGQTFTFDSIANPESTQEQMFQLVGAPLVENCLSGFNSSVFAYGQTGSGKTYTMWGPANGLLEEHLCGDQRGLTPRVFERLFARIKEEQVKHAERQLNYQCRCSLLEIYNEQITDLLDPSQKNLMIREDVKSGVYVENLTEEYVKNLTDVSQLLIKGLGNRRTGATSVNTESSRSHCVFTCVVESRCKNVADGLSSFKTSRINLVDLAGSERQKSTGAAGERLKEAGNINRSLSQLGNLINILAEISQTGKPRHIPYRDSRLTFLLQESLGGNAKLAMVCAVSPSQSCRSETFSTLRFAQRAKAIQNKAVVNEVMQDDVNFLRGVIHQLRDELQRMKNDGNNPTNPNVAYSTAWNARRSLNLLRSFGLGHPRSLPHEDNDGDIEMEIDEAAVERLCVQVGLQSSLASEGINHDMNRVKSIHSSDGQSIEKRLPEDSDVAMEDACCHTENHEPETVDNMRTETETGIRENQIKTHSQTLDHESSFQPLSVKDALCSSLNKSEDVSSCPDLVPQDVTSANVLIADGVDDPEHLVNSASPSLCIDPVGATPVLKSPTLSVSPTIRNSRKSLKTSELSTASQKDSEGENLVTEAADPSPATSKKMNNCSSALSTQKSKVFPVRTERLASSLHKGIKLLESYCQSTAQRRSTYRFSFKAPDSEPSTSISKADAGVQTIPGADAISEENTKEFLCCKCKCREQFDAQQMGDMPNLQLVPVDNSEVAEKSKNQVPKAVEKVLAGSIRREMALEEFCTKQASEITQLNRLVQQYKHERECNAIIGQTREDKIIRLESLMDGVLSKEDFLDEEFASLLHEHKLLKDMYQNHPEVLKTKIELERTQEEVENFKNFYGDMGEREVLLEEIQDLKLQLQCYIDPSLKSALKTCTLLKLSYQAPPVNAIPESQDESLEKTLEQERLCWTEAETKWISLSEELRTELEASKALINKQKHELEIEKRCGEELKEAMQMAMEGHARMLEQYADLEEKHMQLLARHRRIQDGIDDVKKAAARAGVRGAESRFINALAAEISALKVEKEKERQYLRDENKSLQTQLRDTAEAIQAAGELLVRLKEAEEGLTVAQKRAMDAEYEAAEAYRQIDKLKKKHENEINTLNQLVPQSHIHNECSTKCDQAVEPSVNASSEQQWRDEFEPLYKKETEFSNLAEPSWFSGYDRCNI
The following text describes a protein:
Function:
Forms stable clots in the presence of calcium.
Subcellular Localization:
Secreted. Note=Secreted in hemolymph.
Sequence:
MKALILLLLGACQALQPGLEYQYRYSARVASGIPSINRQFAAAGIQADVTVQMAADYSVVVQFSNIEVGDLNKVLDCDLRAPLPIEYHPLEDYVDLLEKPFRVIMNESHVPSYMEGPEEPIWISNVRKGFVNIFRVPLFWSTELHSTKLNYGAVEETLVGRCQNWYTSMKLPVNLAEEVNVQREHFMEEDIQRDAYSSSYTTKTKSKTSSKTSSKTSSKTSSKTSKTGKTSPGQLANVPHIEDTLWSVRRTTDFDMCENLVSLQIHSSKYTEDIIQRSSVASYLIRGDTHRRIEQVVVEGTITVLTNKEQHEHVDTFTNQTLELKAVREVGEPITVTYDVHPHYDWQYDIERPQGDQFIPLEQVLTGRPVTDQIVNSIMEYIKKTVDDLSHRMEHYPAKPENLAYIIGRLVEAVANLDYPYIQTLYTHFDGKGTMQKYIFVQLVIHAGTEPAVNFAVDNLSDILFYVTFYESIGVSLRTPAPIPKIMHSLINGEEGLHHSLGLMNFATLAHDACLSEDRKHFYFDYSCGPKTTCDPELIITNFIPYLVRELGNQGKDVWQRLIYLQALSNLGTPQTINVLKPIILGVTETNIFMRTNAIWSLSAYNMHKTALSQIYEILMPIIENKGEQFEIRNIAFLTLATWGPGHAWWQQLAVSTWHDPSPQFANFVTTTIYSISDSHTKLAETVSRIKHLCKPAAPASILHSTNFFLHEYLFSEEHGSRVNFAWFASVHGAIPEEVFLRIQREFFYGYTKVLKIDGQQRGLYNLMQLMKQKMTKPQKRPQSSAQEIVSGMWEELKEKIGFTSPESASDATLWLKLDRLIYVALQYHFMEGAPIPYGMYSGKPFYDKDLNTLIAFPTEIGIPFSVLYVAEDATWLNINGNPETSMTSGKMKVNVDFIFETSQVQFVDARAHVPWSKRPAVASGVYADTQLVLPLNVHASFDMYSQEIQLSIEPTNTQKIDVIKFEFIPYTVLENNYPGDVLVIENEYKPILHGEVPLFNDKHQAFPSDVGLWIQVATEGDIHHTPSIYEIITQLFSAHTSTHIWEQSIVFDPTLSTTKTVSFTFNYVSTGGSGSLVDRGDYDDGQISQGSFDEDFGQFSQVAGGSDQDIMEVDSFGTQSQTIERIMRLQQALISSGGHVRTISVEVELQGTPTRNYEASLTWAISSSASTRSSKVQVTLIKHPAVGVLEDPYTICLNAQIVKPHFNPFFTTEDVLTANYHSTVKAELFEGETCEEAPVLLLEASFDVSSNVKERVKEAIEKGCDYSTYAPGIDIITSPLYDHSHITATWTPDFPDNLKNITYYVDDIIKASLSKKIEFDHTSAHHASRVEIDATKCIETGLWTVRTEKPYAVSIINELELPAWANPIFTPAPLATTLLYGLTVGRTPVSCTIDETKVRTADGKVFAYEPSECWNAMTLDTTFDQRGAMLVRNTGQWEVRIIWQKEGLVIDMSPTNFLVNGEPAKGTDNRYTVLHHDDSHTIVFESGTSVKVSDKVEVLLGLDHRGHTTGICGNFDGEPSNDMVGPKGCYYTDGPLFALSWASPGEGCASFMYKNLKRDVVWYQENCPHFTYEPTGVTHADALYDCTEWVYHQRTEGQYHCKALSPMPVCRPECVASHPITTSVEYECRFSGHQQQAQQQQQQQVQGTQWEECFPHFYTLTYPSSCIPQ
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MAAGSSNADLTGLIDESYFSALTHARNDADFAQDDDLFPISDEKYAVELQFQEVIMSSAIAAAAALTRPRSSSLPDTLSRAMNTSPVPIVIIDDSSSAGASSSSSSRPSTAATPTAAALVFCKICMDAVPAADAHRASSGCAHAFCGACLAGYLGAKIQDRIADIRCPEEWCPGVLDPALCQGMLPREVFDRWAAALCESMVLGAKRVYCPFKDCSAMMVADGHDDEVTQSECQLGRGNRGKEDLMMLEMAKGKKWKRCPKCQYFVEKIDGCLLITCRCRYEFCYGCGNQWGVTHSSCISA
The following text describes a protein:
Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.
Sequence:
MCLHVLVCREMVNAWFAERVHTIPLCKEGIRGHTEFCSCPSQQSPRADSSVPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDNDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYRTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTRDRDTNRINYMYAQYVKNTMEPLNIPDVSKDKRFPWTNENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEETTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAKMEGKQRSDIPDAQKKIWRESRKNRYREETWFRFPHFSSLCPTQVKASFHQAAVVPSAQTLKITDFSFSDFELSDVETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQRRLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPVQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESSQSKRN
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
METQLQSIFEDVVKTEVIEEAFAGMFMDSPEDEKTKLTSCLGAFRQFWSTLPQESHEQCVQWIVRFIHGQHSPKRIAFLYDCLAMAVETSLLPPRMVCQALISSDSLEWERTQLWALTFKLIRKIIGGVDYKGVRDLLKAVLDKIQTIPNFVSSAVVQQLLAAREVVEYILDRNACLLPAYFAVTEIRKLCPEGALSHWLLGSLISDFVDSFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLRGMLPYDKDLFDPQTGLLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEQFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALGDFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLPMTDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGSMRITLPGTNCMASGSVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSLALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGFRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENAPEHWLQSDWHTKHMTYHKKYPEKLYFEGLAEQVNPPIQLQSQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLKRKLVHAIMSSLKDNRTPGWCLSETYLKCGMNAREDNVWIPDDTYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLVITALPEPYWIVLHDRIVSVISSAVLSSGSDWLGYPFQLLDFTACHQSYSEMHCSYVLALAHAVWHHSSIGQLSLIPKFLSEVLKPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMLEIGVAFYEMLQAVDQHSNHLAYMDPICDFLYHIKYMFTGDSVKDQVERIICSLRPAMRLRLRFITHISKMEPAAVPVSNSSSVQQTSSASSPTAQSTAGAAIPLSVTQ
The following text describes a protein:
Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus, cis-Golgi network.
Sequence:
MVGFNAEFFAVTYGAIVTSLLEELHDPGMVTKELDRMGFNIGQRCVDEYLANSSSICTKFHHTATGVLGGLKMFLGCASGTITGCEPECSAYTIFVENNPLEKYVKLPAQLDRLVYSQIVCGAIRGALSLIGYNVTVELIPAHNAMVHPLHLRVELQNEITESFAC
The following text describes a protein:
Function:
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
Subcellular Localization:
Cell membrane. Secreted.
Sequence:
MLLKCLHNNLCQKYSAHAFQFSPRNVLWLLVVCLRSYNKRPCLEFSQLSVKDSFRDLFIPRIETILMMYTRNNLNCAEPLFEHNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFIRILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGVSLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSKLDYTDAKFVDVIHSDSNGLGIQEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNCYQAKLFKDVLKERMEGRPLRTTVFLDTSGTYPFCTYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFVNISSIGLTYFQSSNLQCSTCTYKIQSLMLKSLTYPERPPLCRYNIVLKEREEVFLNPNTCTPKNT
The following text describes a protein:
Function:
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKQLLDFLPLVIFFAVYKFFDIYIASGALIAATALQLVVTYALYKKLEKMHLITFAMVTVFGTLTLVFHDDAFIKWKVTIIYALFALALGVSQLLNKSILKSMLGKEMKVADNIWAHVTWYWVSFFAICGLVNIYVAFSLPLETWVNFKVFGLTALTLINTVITVFYLYKHLPEDQRKELK
The following text describes a protein:
Function:
Required for KRAS signaling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases (By similarity). Required for lymphocyte development and function (By similarity). Not required for myeloid cell development (By similarity).
Sequence:
MASLDRVKVLVLGDSGVGKSSLVHLLCQNQVLGNPSWTVGCSVDVRVHDYREGTPEEKAFYIELWDVGGSVGSASSVKSTRAVFYNSVNGIILVHDLTNKKSSQNLYRWSLEALSKDSSPTGIIVSNGDYDREQFAENAVPLLLIGTKFDQIPENKRNDVLTRTAFLSEDFNAEEINLDCTNPRYLAAGSSNAVKLSRFFDKVIEKRYFTRDPSQMQSFTDRRRFNFKSLHSD
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.
Subcellular Localization:
Nucleus.
Sequence:
MAAADAAASKPNEDLAPAAEALAAARERNSRFLSGLELVKQGAEARVFRGRFQGRAAVVKHRFPKGYRHPTLEARLSRRRTVQEARALLRCRRAGICAPVVFFVDYASNCLFMEEIEGSVTVRDYIESTLETEKSPQSLLDLARTIGQVLARMHDEDLIHGDLTTSNMLLKPPLEQLNIVLIDFGLSFVSALPEDKGVDLYVLEKAFLSTHPNTETVFEAFLKSYSAASRKSKPVLKKLDEVRLRGRKRSMVG
The following text describes a protein:
Function:
Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSSIKIECVVSETYKIGESPVWEEKDGTLLFVDITGQKVCRWDPGTKKVQSVSLEAPVGSVVLRKSGGYVMAMGNTFSALNWQDQSVTTLTCVDEDKPNNRFNDGKVDPEGRFLAGTMSQEIRPAVVERNQGSLFTLYPDHSVVKHFDMVDISNGLDWSLDHKTLYYIDSLSFKVDALDYDMKTGKSSNRRTLYKLQQDEGIPDGMCIDAEGKLWVACYNGGRVIRIDPETGKQIQTVKLPVDKTTSCCFGGPDYSEMYVTSACEGMDEEWKKRQPQSGGIYKITGLGVKGIAPTAFAG
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQLHDHMKYIDLGCKMACIPRYQWKGRPTERQFYASEQRIVFLLGTICQIFQITGVLIYWYCNGRLATETGTFVAQLSEMCSSFCLTFVGFCNVYAISTNRNQIETLLEELHQIYPRYRKNHYRCQHYFDMAMTIMRIEFLFYMILYVYYNSAPLWVLLWEHLHEEYDLSFKTQTNTWFPWKVHGSALGFGMAVLSITVGSFVGVGFSIVTQNLICLLTFQLKLHYDGISSQLVSLDCRRPGAHKELSILIAHHSRILQLGDQVNDIMNFVFGSSLVGATIAICMSSVSIMLLDLASAFKYASGLVAFVLYNFVICYMGTEVTLASGKVLPAAFYNNWYEGDLVYRRMLLILMMRATKPYMWKTYKLAPVSITTYMATLKFSYQMFTCVRSLK
The following text describes a protein:
Function:
Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol.
Sequence:
MSGEPGQTSVAPPPEEVEPGSGVRIMVEYCEPCGFEATYLELASAVKEQYPGIEIESRLGGTGAFEIEINGQLVFSKLENGGFPYEKDGSRCPGQKEEDMSEKSVGWILPAFQEIITCAPNILTHPGACSRSLLLRCNCPPPNTASGSCPSHRNC
The following text describes a protein:
Function:
Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway. Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling. May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
PLSSETVLTMVQLSPSPVLDLAPMSEHSEVTAERQGSPRSPTAEAPPVLSSLQLALASSAPTYQGYDTYIENGLICLKHKIRNIEKKKLKLEDYKQRLKAGEALNQDQLDAVEKYDEVVHNLAFARELQKTFSSLSQDLLKAQRKAVRREQVQKTEVEKKRLCTVLQVHYILQSLQQEHVRKDFRSGLNGAPFLSARELERLLGFSERVGCKRNESMSVEDQMEQAAIVYGDLLEGADKPVAGTTYKHLKEQLARLLDCGYFDHIPVPHSESLEEAVAEVVKKPLAPKRPAAGVPEPSVPLPKCEVPAREFLNRRYLPETDFRAQEQEGQPVPSWKAEFLALKQQEPPDSWDMEYTEKPASPPQSALKPWRAAPAPVPAPAPAPMPAPAPTPVPKEQVEVKPPPAAAAAEPKQASTPSPSRAHQGIELLQSVKLVQLVCFLSPHGGVQRRERKSRPEQEMKVFSAFISLMVLSYEIGANGLIQAPKSDPSPVAVFTSPSPLPADPELRKQKLQDLMEEIQGSFSFMQVLQASAPAGLPLSACWGRPTPTGQNPGPKSRKLIDSVLEGEGSPGGGTSRLKHSALGTSTPLESSSQWKCLTERPVKLCPPPQPAPVPAAPVPPKSSLTNAQTLCAPVLKYFCLLATVHVAHALLLVFGVRWPTRPAASQSCGSPFSLFLNTSFSPLVQVALIHHRWEFIYGNITSKNRTGNLHKDCFIFSSLASITFPAMETIFLQPVPLFTNSEGYHGTRLQVCARKEPQATGGFESYKNGMPSPGGNFIQPSYPARECTPILYGARESGFQQNYKRGGLTGQRASSRATWSDSSQVSSPERDNETFASVDSGQGDSRCITPIDVPVSAPGATLMPVHVYPLPQQMRVAFSAARTSNFAPGTLDQPIVFDLLLNNLGETFDMQLGRFSCPVNGTYVFIFHILKLAVNVPLYVNLMRNEEVMVSAYANDGAPDHETASNHAVLQLYQGDQIWLRLHRGAIYGSSWKYSTFSGYLLYQD
The following text describes a protein:
Function:
Oxygenase component of the 4-hydroxyphenylacetate (HPA) 3-hydroxylase. Catalyzes the hydroxylation of 4-hydroxyphenylacetate to form 3,4-dihydroxyphenylacetate, using FADH(-) provided by the reductase component HpaC to activate oxygen. To a lesser extent, can also use reduced FMN. In vitro, has hydroxylation activity toward tyrosol and various cinnamic acid derivatives, catalyzing the hydroxylation of p-coumaric acid, caffeic acid, ferulic acid, and coniferaldehyde.
Sequence:
MKPEDFRASATRPFTGEEYLASLRDDREIYIYGDRVKDVTSHPAFRNAAASMARLYDALHDPQSKEKLCWETDTGNGGYTHKFFRYARSADELRQQRDAIAEWSRLTYGWMGRTPDYKAAFGSALGANPGFYGRFEDNAKTWYKRIQEACLYLNHAIVNPPIDRDKPVDQVKDVFISVDEEVDGGIVVSGAKVVATNSALTHYNFVGQGSAQLLGDNTDFALMFIAPMNTPGMKLICRPSYELVAGIAGSPFDYPLSSRFDENDAILVMDKVFIPWENVLIYRDFERCKQWFPQGGFGRLFPMQGCTRLAVKLDFITGALYKALQCTGSLEFRGVQAQVGEVVAWRNLFWSLTDAMYGNASEWHGGAFLPSAEALQAYRVLAPQAYPEIKKTIEQVVASGLIYLPSGVRDLHNPQLDKYLSTYCRGSGGMGHRERIKILKLLWDAIGSEFGGRHELYEINYAGSQDEIRMQALRQAIGSGAMKGMLGMVEQCMGDYDENGWTVPHLHNPDDINVLDRIRQ
The following text describes a protein:
Function:
Iron-storage protein, whose ferroxidase center binds Fe(2+), oxidizes it using dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the BFR protein shell.
Sequence:
MASKELLDLLNDAIARELQVSIQYMWQHVQWKGAEHFAVKDELKKIAIQEMKHAESIAERLFYLGGIPTTKPSPIFIGETLKEMLEQDVKDEQNAIELYKKIIQKAREEGDITTAKLFEDILKDEEEHHDTFTSLLEK
The following text describes a protein:
Function:
Catalyzes the NADH-dependent reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. Is required to provide the methyl group necessary for methionine synthetase to convert homocysteine to methionine; the methyl group is given by 5-methyltetrahydrofolate.
Sequence:
MSYAKEIDTLNQHIADFNKKINVSFEFFPPKNEKMETLLWDSIHRLKVLKPKFVSVTYGANSGERDRTHGIVKAIKQETGLEAAPHLTGIDATPEELKQIARDYWDSGIRRIVALRGDEPKGYAKKPFYASDLVELLRSVADFDISVAAYPEVHPEAKSAQADLINLKRKIDAGANHVITQFFFDIENYLRFRDRCASIGIDTEIVPGILPVTNFKQLQKMASFTNVKIPAWLVKAYDGLDNDPTTRNLVAASVAMDMVKILSREGVNDFHFYTLNRSELTYAICHMLGVRP
The following text describes a protein:
Function:
Non-catalytic component of the proteasome.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MIFNSEFSGQQQHTTQPIVTGGSVIALAYKGGVVVGADTLCSYGSMADFKNVEKIAQVSKNTIYVSSGEFSDFQQVVRELAKIDRSALQYDDGVHPSPRDYGNYLARLSYKRRCKINPLYLQNVIAGFHNGERYLGLVDIYGTYLESNFVTTGFASYFCKAIISNYWNENCTLDQAKQVIRECFKVLFCRDCRAHDVIQLAYVDEQGTHIEQPERVETKWDFSGFKNRANEKLHTQ
The following text describes a protein:
Function:
Catalyzes the attachment of glycine to tRNA(Gly).
Subcellular Localization:
Cytoplasm.
Sequence:
MEKIVGLCKRRGFVFPSSEIYGGQGGVWDYGPMGIALKNNIAHAWWQDMTRLHDHIVGLDAAILMHPNVWRTSGHVDHFSDPLVDCTVCKSRFRADQVAVPSAGGPCPQCGGALTGVRNFNLMFSTHMGPTDERASLLYLRPETAQGIYVNYKNVLQTTRLKVPFGIAQIGKAFRNEIVTKNFIFRTCEFEQMEMQFFVRPAEDTHWFEYWCAQRWAFYQKYGVRMNHMRWRTHAAHELAHYARAACDIEYAFPMGFRELEGVHNRGDFDLTRHAQHSGKDLCYVDPDPNLDAAARRYVPCVVETSAGLTRCVLMFLCDAYTEEYVQAPNVAFSETTQTADQEGAARTGEMRIVLRLHPALSPTTVAFLPLVKKDGLVDLARAVRDELREDFACDFDAAGAIGKRYRRQDEVGTPFCVTVDYQSKEDDTVTVRLRDSMAQRRVSRAFLAEFLRTEIKHYRRP
The following text describes a protein:
Function:
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Internalized receptors colocalized with RAB11A.
Domain:
The 329-DSEL-332 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for GRK2 and GPRK5/GRK5 to promote agonist-induced internalization (By similarity). Thr-351 is a major site for PKC-induced internalization of the receptor (By similarity).
Sequence:
MANITLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHRVCLMLWALAVLNTVPYFVFRDTIPRRDGRIMCYYNMLLLNPGSDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLQLHHRGRQRTGRFVRLVAAIVVAFILCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVLTCPDMLHKLRRSLLTVLESVLVEDSDLSTGPGKRCRRRHRRRASSTTTPASTLLLADRFPQLRPARLIGWMRRGSAELPRRVREQSQEKQGSLSCTLD