lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus, nuclear pore complex. Nucleus, nucleoplasm.
Sequence:
MNPSNIFGRPQAAFQAPNTNQSGNLFQTFAQQKPTQGVSFGQPSAFSQPAFVQPTPQPPVFTPTFGQTGGLSQGSGQTSSFSFLGTHPAFGQPSLGQGGTLGFGQPPPPSYSQATGQTQNSAFGQPSAFSLPSYVSQSSSTSFSSTVTSQPSFGQLSGLPVPAATSISSISGRAENPTGGNQFSFKPPNEAVFKPIFSVSPEPTSTNMSSASETAGSSKVVDNSSGGSLFSCVKPSALGFSFSQPAAAPSVSLSNSNFSQKETVGGGGSSIQFTFSQPANPSSSSTSASQPTTPSTFSFTPQSLQPQSDTKVPAFGGTGIGPFAFGVPKTVRTEDKTGDGQSSGGETAFVSFGMKRKEEPADAAKSDPSETGADGPRQPAKRPLLRSRVMAGGLFRVAMSDVLKSKVSPVKREDNLPERPDPPGPSSDLATALLRPQASLVSKKAEDVSVQPEPQTRASGRRAARKESTDSLGGLSPTDATVIQCKNIPSNLNRKDLLMQHFGHFGKVLRVYSKPQKNLAVVHFQDHTSAAKAKKKGKLFQRNEIQIFWQRKKQSPGDKPARPSEIKDVIEDPESASALLQSPPIHKPLPRANPISMSGSLTKGSPIKKSSIAKTLQFESEGPFESVSEERSIERPINILPSVLQPLVGQVAECAEERYRLLEQRDKILRQARPKRTDLDMSKVFVGTCPDMCPEKERYMRETRNQLSVFEVVPDTEKVDHYAAIKEYSRSSADQEEPLPHELRPLPVLSMTMDYLVTQIMDQGEGNCRDWYDFVWNRTRGIRKDITQQHLCDPETVSLIEKCTRFHIHCAHHLCQEPMMSFDAKINNENMTKCLQSLKEMYQDLATKEVYCPKEAEFRQYNVLVKLNDGDILREVQQFRKEIRESPEVTFAVQVFAALNSNNFVRFFKLVSAASYLSSCILHRYFNQVRRQALKILNVAFTVGSQRSTIFPVEDFVRMLMFRNATEATEFIQQYGLTVSDGMVELSRTAYQEPDYSLPQKKSVAIEKKRTVLIGEVVNGGPLPNPPQHSPVCSFDSNNKYTGDGLSSEPPPAVLKAPAERQIFMEPEPRPQVKTRLLAEPRLFMGLSEPVKADDTEETGEKSQTAESTLPVVQQPIFPPILAPQPVRPPSPPPKPEPTYTDQDIMAEVDAVVNEVLEAEVSDVTRSAAEYVSAALSASDSELEIVVSEVLHQLLREVSTSEIIAEKERIAEEKRKEEEARRKEAFLQQFSAELCAKISDEVLTESIRATAEAEIRLALEEKAAYIARCTAEECESIIEETLAEEVASIAQVILDEGLRHIRKFIKRWRDVVAVRRQLKRQMRGFPAAPGCVDPQFKLKALVPSAPSNHCLDLLAQGMVNLGNSGNMAVSCTSLLRMRQEAVHQMKVSYYYNLLMSERVWMPLDLPTLVAESTPNAPDRIFWKATLLMPSSCDSDITFASRILTDWLEVKLGGGNESEESEKQSKGQVKTLCVSHSLTNIRGQTHEVYISVKACHGPLSAEDQCLLEEQKELHGTNALLMLLPPVNSAGQGEEEEEEEEEEDLPLLSALLQLRQVQQASCWHSPLPLAVVVAGNQIGDQGLEQALLLDMLVKDGLISEYIFVHIPATLNDLQGSEQMSHVVRWLSARSPASPALSSQTLLQVVELGLCREFYSRLQEDKLDRKNAGLPSQHPEPIVELCNSVLSFLSGVVSSEHLSALCWPPPEFSLPENSELIPHQAWNSPEHLQWLRRSILSRQLPEWDLPPVDASWPHLCASIFQYVSQIPTSPLSQPILMSRLENLLRRVNYQHADEDDYEKAGPSFHEIPWDDIICLCVEHRMKDWSLDTLVAKDALTDDGEILVYFNKDSLKSFQPPDIWIEAVKQTYQEKRQASEVCKVKHSPATRLYLRQKLFQSHIDIEERPTVEDTAQIPIEQKFKQMLSSLRDMNAESQRIGEQTQHRAGENPLRRSSFPLALRKHPAAGTAHIQETDVVELVGKVSSDRKMNRMFAPDSTQSPIMERLQHTLSTVQEMNAEGQRIGEQIRRRIEADALSSASLPLFLPSTLLSSPPLVLTTSKRPSAAVHIQEMDDLDKIASRNDKSRPVPLFQRFEDLKRELSSQREEERACGLKLNCLLDIVDN
The following text describes a protein:
Function:
Catalyses the transfer of galactose onto proteins or lipids.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MLWVYRDVKSRTMSKALKFARYKNFIKAQMLTKSFDQAKLKSAGNAGVLVTPIDNTTRLTNDSGVPFHPLLHGNLTINITEAEAAYAKLMTEFSNVKDRGSIDIFETRRGIHDLTVAVIIPIRNRPAHLRLLLGHLIPILQRQLRRFQIFTAYQFGDGTFNKGRLMNAAFRYLLDATRVEDVKFDCFIFHDVDMLTESDLNTYECFPGTNKVKHMSYTVNKFNYTFCCGMTVGGVLSFTEEQFIKVNGFSNHFWGWGGEDDDMNARIKENKLEVVRPHLSVGRYTMIPHDRDKLNPYNAKVLKQLGRRQRSNFNGLAGCPAQVLGVEVRPLFVNILIKVEED
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Sequence:
MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRTASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQPEGQCRIEYKQRI
The following text describes a protein:
Function:
O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MQSNGVVIFRLVLAFFRFVLVKMFEKTSIAFLSLVEGLSMKGTAEDDVATFDQLSKRWWEPNGPMILLHRLNKLRVPMVVEGLIKVGKLDRKQRYTTDALKGLNILDVGCGGGIYAEALAKLHANVVGIDPARHLIEVAKAHAEAQSDIKDRCHYYEQSMEEHWQGAANKYDVVVLSETIEHVVDKSSLLKHVAEVLKPGGSVFISTWNKTSWSWLLAVVVLENIMKRLPKGSHDYDKFVSPEETEAILEAYGCRTIEQRPFYLKFWESEWVWVPFNQLTYALHAVKG
The following text describes a protein:
Function:
Component of the target of rapamycin complex 2 (TORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization and anabolic output. In response to growth factors, TORC2 phosphorylates and activates AGC protein kinase family members, such as Akt1. Within the TORC2 complex, Sin1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by mTor (By similarity).
Sequence:
MATYSNQHWLLSHIRNSFISTDDTGMCETVMLSDDMPKHYLRKFGNSGAGGDHYHWRRAHKTPPTGGGTTPERNTRHPDAPLQEVDFICYPGLDLSDDEEDMSTHSFDIQMYPEVGAHRFRSNTAQKLEKLDIAKRRAARIKSVNYQEEVQPPESDDFFKRKELPLSKAERVKNEPKANDDDLSDEGVQSQLTEQLAKSPKQAQNRFIEFARFDGTSQVGMQTKRINVFLNMLPEPDRNYPLKICVVATAKIQEVIGFVCYRTSLQYPDVPLKSLQHYALYMTEDNDDMEDFPPLDNREPCSKFGFSQLTLAERRPLAPVTRVDYHSQLGSKSMTSVEDKTALSDAAVKALQNISLNGGTSDPGGGGGGGDSPHDNVKEYEKRLLNHNDMLEAPMHRTFRLNIIDKRFFKSDVTLGISGERIEIDQCKNAKFWPQKKPVSTPIDFVAHCEILERRHLKALLRIWLKSNSSSPSFSTGCTSAPINASVTTLNAGSGSGGIAHSPSSPGHSSGLFSSSNIRFKHYDFDTDTHTAEQIHNKLNCILEMRSSDLRREFLLQRDRKQEKRQLKL
The following text describes a protein:
Function:
Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity).
Sequence:
MEVGMIPRVYLGHEWFGAERILSEYQVPEDCGAQVLFLGIPRNAPEDGGNIEALEYEAYPEMAIKEMEKIRQETIEKFGVKEVFIHHRLGLVKIGEPSFLVLAVGGHREETFKACRYAVDETKKRVPIWKKEIFKEGKGEWVLGEKKNASGQTK
The following text describes a protein:
Function:
Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
Subcellular Localization:
Secreted.
Sequence:
MFFPGGVQPRGHAMFWRSQGFRTFQDCCLKKDDSEFGNWKQMGSEWNETQDPGGLRGPPKGFYRRKFPEPHLGQWYFIAGAAPTKEELATFDPVDNIVFNMAVGSAPMQLQLRATIRTKNGLCVPRKWIYHLSDGSTDLRTEGRPDMKTKLFSSACPGGIMLKETGQGYQRFLLYNRSPHPPEKCVEEFQSLTSCLDFKAFLLTPRNQDACELSSN
The following text describes a protein:
Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Mediates resistance to enteropathogenic E.coli infection (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MINIPTSILCRLGARSAISRSFGTSVVTKSEAKTPIQKFGWEYLKKQRDMKRPIAPHLTIYQPQLTWMLSGFHRISGCVMAGTLLVGGLGFAVLPLDFTTFVEYIRGWNLPCAVTAVFKYIIAFPIIFHTLNGIRFLGFDLAKGVDNIGQVYKSGWLVFGVSAVIALAIVINSCQNKSKAVKTA
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSFRRPAMYQLGIETGPMVPTDLYPPANVPLQDPPSASEREVAAQFYKFQAEVRDGPLYTGSVEVKTGPNGQKKASRILIEVDDACDDGIRRYTDRYRKKRKVGRSIDEHPYILELFPQELHEAMGAKKEAGEDVKRRRAGISKFANSLIQADEADLSPVELEARLKAQQALTMVDDKELEARLGQEAADSEEEEIEDDVYDDEDDNDYNAEGYFDNGDEDDDDGDDDEANF
The following text describes a protein:
Function:
Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.
Sequence:
MFHDPYKKNAHDIPGLVPEVSRESITASKLPKLVDPVFKPGALPVIPGIIPEKVEKEDKDASKQVNGTTKAKLKTRKEADAVKFRAPGIPVSQQIHTVFFNGMPKISDKALDGMLGLLPTISAWTRLKDVCGYNTDSGFITFSSAMGVAVARRCLGELTVMDGEEEKKINVTCEENTMSKIDDVNDALILSETGKSPANLIDSMQAIIDGTEVAEEEEDEEEEEELPLSQITFDVDPFYDVIEPDRTNLKNDIKNFRNSAVNAEKDAFAKRGEFGKQRISRRTTAAEKVLGHVKGTSTSSSTTTTNRATDLRLSEKEREMYREYSRELHSIENRDKISDEDYAVEIMDKKEDEVEDLFIEAQKRWLSYENGRLRDLVSQWKQVEPEELENNRKTAIARLLDYDDDKERSKERHIYYYDHATWSRNRAEFRDGEIRREKEEAEEGEEAEVAAPVGPITISLKPKEDPKEAVDVLSKPVSVPDVGRLTEYVGEQVEEFLGAKEEDLIKFIVDHIVSGHSAQELITELEGPLDEEGAILVKNVWGWLQ
The following text describes a protein:
Function:
Catalyzes the conversion of dopaminechrome to 5,6-dihydroxyindole in the eumelanin biosynthetic pathway originating from dopamine. Catalyzes tautomerization of dopaminechrome to 5,6-dihydroxyindole during eumelanin biosynthesis. Acts both dopaminechrome and N-methyl dopaminechrome but not on dopachrome or other aminochromes tested.
Subcellular Localization:
Secreted.
Sequence:
MQSMTIFNIITQLVFLSKTLNGNLSVQPVFQTLDGYEYTSQSFSQNLQSESQLEIVYEWKYLDFLYSTFVQRQQSILNGDFVPKNNLPLGIDVHNNRLFVTTPRWKNGVPASLGTLPFPPKESSPAIKPYPNWEAHGNPNNPDCSKLMSVYRTAVDRCDRIWLIDSGIVNATINLNQICPPKIVVYDLKSDELIVRYNLEASHVKQDSLHSNIVVDIGEDCDDAHAIVSDVWRFGLLVYSLSKNRSWRVTNYNFYPDPFASDFNVYGLNFQWLDGVFGMSIYYNKKIMERVLYFHPMASFKEFMVPMNILLNESVWQTNTQEYAKYFIPIGDRGYNSQSSTSGVTRNGIMFFTQVHQDDIGCWDTSKPYTRAHLGKFHNMENSNLIQFPNDLKVDKEKDQNVWLISNRLPIFLYSNLDYGEVNFRILKANVNKIIRNSVCNPDNSYINTSKSAFVLIEEGQCF
The following text describes a protein:
Function:
Involved in the anaerobic metabolism of phenylalanine and phenylacetate. Catalyzes the oxidative decarboxylation of phenylglyoxylate to benzoyl-CoA and CO(2). It can also react slowly with 2-oxo-3-methylbutanoate and use different electron acceptors such as benzyl viologen, methyl viologen, FAD or FMN, but NAD seems to be the physiological electron acceptor. Also catalyzes an isotope exchange between CO(2) and the carboxyl group which proves partial or complete reversibility of the oxidative decarboxylation reaction.
Sequence:
MGRAYSTIAFDPAKCDGCGDCMTACAQAKTGTDDIARSRIQIYGREGAADKTFELALCRQCADPKCVTVCPAGALNKDGTSGVIGWDATKCVDCLLCTVGCAYAGIALDEATGHVAKCDTCDGNPACVPACPHGALKHITTANIYNEVGDWEDLFAPGLAGCQGCNTELLMRHTLRRVGPDTVLATPPGCVPGMGSVGFNGTTGTKVPVFHPLLTNTAAMLAGIKRQYKRVGRDVQALAIAGDGGASDVGFQSLSGRAERGEQMLFMVVDNEGYMNTGMQRSSCTPYGAWTSTTPVGETSRGKTQDAKNLPLIMVNHRCAYVATASTAYMEDLYDKLDKAIAASKNGFAYLHVYSPCTTAWRFPSNLNMEVARKAVETNFVMLWEYTPQDGLHFTKPVDDPLPVTDYLKAMGRFRHLTPEQVEHIQKKVVENQKFVERMTEHAHVG
The following text describes a protein:
Function:
Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. The BCR(KLHL17) complex mediates the ubiquitination and subsequent degradation of GLUR6. May play a role in the actin-based neuronal function.
Subcellular Localization:
Postsynaptic density.
Sequence:
MPYFPCPTCLRARVLGPEPTIGDPTAPRAPATLWAGPQAVCFPLPRQPASSSRPGNCRCYTCRIQGANPAKARRAKGPARGPQRGRAACGPGAGSGPRQGWLRSQGQHVRGPGALGVSRVHFLNKLAGPAGPGGFLEIVGRRDPGASGWRRKAGRRRRIRGLRCVPEAAGERRRRGGRRRETAAAGRRREQGTPSRPPPPSSPPAVRASGHLCVLRGAAAGPVAEPMQPRSERPAGRTQSPEHGSPGPGPEAPPPPPPQPQPQPPAPEAERARPRQARPTAPMEGAVQLLSREGHTVSHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVCMGTRRSCLGVAALHGLLYAAGGYDGASCLNSAERYDPLTGTWTSIAAMSTRRRYVRVAMLDGNLYAVGGYDSSSHLASVEKYEPQVNAWTPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAAACMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTSL
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
SKLQDDNSYFLVFGLRVVVPYILERREYLWTYFKILYRYYLSWVFLFIIRNCIYHACLYIYVLVEKILRVQPEVRKLYQLVRAPDAAAAEERVLTEVVGKGLFDVLRKQHGAAFYSFIKKKICPLAGDVMHENFGLGSSEILRLSHEVDIIVNGAATTNFMDRYDVALATNTEGVMHLCHSAKQCDNLKMLLHVSTAYVAGEQAGLLLEKPFQIGEALRQGYTLDVEAEVQLVDRIKSKLRIKSSIHNKLEKTTMKKLGLKRAMHFGWPNTYVLTKAMGEMLLRQLGGDLPVVIVRPSIITSTFQDPMPGWIEETRTIDAIFVAYNDQTLPCFIFDGSVIFDLIPGDMVISAMMAAINSHWNKQAQVIYHVTSAHQNPIQLSLIEESMYKYFHTNPRTNKDGESIKNKRVLMFKRFAYFQAYMALRYKLPLEIMRAANALFGGIYTKNYNKLNRGYNILMTVAKLYAPYDFFKGCFDDTNLRKLWKATAMDQNDASKLILILTASTGAHTW
The following text describes a protein:
Function:
Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
Subcellular Localization:
Secreted.
Sequence:
MNIKLFASLSFLILLKTSMAESEDVRVKLCGREFVRTVVASCGSFRVKRSMPDSDLHFAYPYRNLQNWLDRDLVVHQRGSPAVEDEQWRERDTPESVRGHPDPRQHTSPPAEPLDHSTTMQDLSVSSRSRRDAGPAGVCCTSGCTMNELIQYC
The following text describes a protein:
Function:
Nuclear transcription factor with zinc-dependent sequence binding specificity. Required for carA-1 and carA-2 expression in early development. Also required throughout later developmental stages - where it has a cell-autonomous role that is distinct from its capacity to control carA-1 and carA-2 expression. Required for terminal spore differentiation but not essential for cell differentiation and cell sorting. May function to help insulate distinct pathways from simultaneous and universal activation by cAMP.
Subcellular Localization:
Nucleus.
Sequence:
MSSIEQLYSTTQFPSLSSCNTNINNTNNNNNINNINNNTNINTGNLLKNTFFKNNIIYNTNNNSINNNSNNNIINNNNNNLLNSNNQNSFQNQNNLNSIHNHNNNNNNNNSNNNNTSNSENLDSLKSALLSSNIFNGSSSSIAHQNLINLIISSQNNNNNNGNSNSNTPDQKSTMADILLNSSVPDYFEWCSDIINMPKDGNEKSNNSNGGNNNGNNNGNNNNNHNNNNNNNSNNNNNNNSDSVPSPQNNYQSPQSDNQSSMVPSFNFSNQNSANSSNNNNNNNGSSNNNNNVRSEPTTPNDESNNNSNNTNNNNNNNNNNNNNQQQQLSSNQNSSPLIYSVPSYYVPNYGVVLSAPMKGNSSSSILPPQAWPQNNNNNNGNSNSNNGNNNASGFSDFMFNGSNIDYNSIMNNNNNNNNNNNNNNNNNNNNNNNSNNNNNNSNNNNGNNGGMFNGGFVNNNNHNNNNNNNNNNGNLNFHNFLQFQNQLQNSNQQQQQQQLQQQQQLQQHQQQQQQLQQQQLQQQFNIGKPCNINQKKGRGANNNNNNMPIGNQASLVISHPSLKMEGHHHLQQQQQQQHHHQHQQHQQNGNGNNTQIVNSAFLDLSSPDSHNQMSPSSPICLPESPMGAQHWESGLDPSSLQKQNEINPPISVRSNVVFFEPYLAGEPGRHKACWNLLEPMHRNYYQPIQFKLPSFPDTSLPITQIDDKTGIFDSQRFLAFNNPQAMSKYESYRIYIHPSLGYSGNAKRFKQQPDVNEKALILDGNVYDGHLNPIYNCKICTEYYQTKSYFSANPHAKGKVLLVKNNILTRVKDGGFTLSLKPMCCSGHNSHIPLYFHFTLTNPLTNEVVLQSLINVNVKQWKKSVPNKSKKQRFE
The following text describes a protein:
Function:
Required for the assembly and stabilization of PSII, but has no PPIases activity.
Subcellular Localization:
Plastid, chloroplast thylakoid lumen.
Domain:
The N-terminal helical domain blocks the interaction with the potential target PSII subunit chlorophyll protein 47 (CP47).
Sequence:
MAAAFASLPTFSVVNSSRFPRRRIGFSCSKKPLEVRCSSGNTRYTKQRGAFTSLKECAISLALSVGLMVSVPSIALPPNAHAVANPVIPDVSVLISGPPIKDPEALLRYALPIDNKAIREVQKPLEDITDSLKIAGVKALDSVERNVRQASRTLQQGKSIIVAGFAESKKDHGNEMIEKLEAGMQDMLKIVEDRKRDAVAPKQKEILKYVGGIEEDMVDGFPYEVPEEYRNMPLLKGRASVDMKVKIKDNPNIEDCVFRIVLDGYNAPVTAGNFVDLVERHFYDGMEIQRSDGFVVQTGDPEGPAEGFIDPSTEKTRTVPLEIMVTGEKTPFYGSTLEELGLYKAQVVIPFNAFGTMAMAREEFENDSGSSQVFWLLKESELTPSNSNILDGRYAVFGYVTDNEDFLADLKVGDVIESIQVVSGLENLANPSYKIAG
The following text describes a protein:
Function:
Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)). Transport is electrogenic. Following sequestration of NH(4)(+) at the periplasmic face, NH(4)(+) is deprotonated and neutral NH(3) is transported into the cytoplasm. Neutral NH(3) and charged H(+) are carried separately across the membrane on a unique two-lane pathway, before recombining to NH(4)(+) inside the cell. In vitro can also transport the larger analogs methylamine and methylammonium. Also acts as a sensor of the extracellular ammonium concentration.
Miscellaneous:
MISCELLANEOUS: Specifically binds 1-palmitoyl-2-oleoyl phosphatidylglycerol (POPG), which increases protein stability. POPG is an essential cofactor for transport activity and, in the absence of POPG, AmtB cannot complete the full translocation cycle. Can also bind phosphatidylethanolamine and cardiolipin-like molecules, leading to positive allosteric modulation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The C-terminal cytoplasmic domain plays a significant role in normal function and it might also mediate co-operativity between the three subunits. The C-terminal cytoplasmic domain is also required for interaction with the T-loop of GlnK.
Sequence:
MKIATIKTGLASLAMLPGLVMAAPAVADKADNAFMMICTALVLFMTIPGIALFYGGLIRGKNVLSMLTQVTVTFALVCILWVVYGYSLAFGEGNNFFGNINWLMLKNIELTAVMGSIYQYIHVAFQGSFACITVGLIVGALAERIRFSAVLIFVVVWLTLSYIPIAHMVWGGGLLASHGALDFAGGTVVHINAAIAGLVGAYLIGKRVGFGKEAFKPHNLPMVFTGTAILYIGWFGFNAGSAGTANEIAALAFVNTVVATAAAILGWIFGEWALRGKPSLLGACSGAIAGLVGVTPACGYIGVGGALIIGVVAGLAGLWGVTMLKRLLRVDDPCDVFGVHGVCGIVGCIMTGIFAASSLGGVGFAEGVTMGHQLLVQLESIAITIVWSGVVAFIGYKLADLTVGLRVPEEQEREGLDVNSHGENAYNA
The following text describes a protein:
Function:
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MGGAARGGGRGGGSSGALCRLLLLGFCCWVAGAAAVRGNDNGDTLPESIPSAPGTLPHFMQEPDDAYIIKSNPIALRCKAMPAMQIFFKCNGEWVHQNEHVSEESLDESTGLKVREVFINVTRQQVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGVSQESENCTDGLCIQGIENASDIALYSGLGAAVIAVAVLVVGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNSSMQPDLTVSRTYSGPICLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKTHSGTFPHGNTRGFNTIHPRNKPPYMQNLSSLPTRTELRTTGVFGHLGGRLVMPNTGVSLLIPHGAIPEDNSWEIYMSINQGEASLQPDGSEVLLSPEVTCGPSDMVVTTPFALTIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALAGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDNTFPAQTGPKAFKIPYSIRQRICATFDTPSAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQHDGDLDSLACALEEIGRTHTKLSNIPETQLEEPDFSYSRQNGL
The following text describes a protein:
Function:
Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.
Sequence:
MILLIAEKPSIAEMISRNYGEGAKKLDNVSFPTYTFVQSFEGSKETFMCTSVAGHVFEIDFDAELNGSSVPQERLFERGHVHYSFTDSGSTVAKHLKSIGGKAMQLILCLDNDREGENICFEVLKVLKPTLRSDCRVRRARFSAVTKAEIQNAFRNLDKPDQNLSDAVEARQELDLKIGVAFTRFQTAHLHAQFADLQSSVISYGPCQTPTLSFCVSRHDEIQRFRPKQIFSLDVCALIGDQPHSLRWQGVPSESREVIEEKRTGLFGKSATKCLKVLSFKSSKSTLPRPLPMNTVALLKAASTVLGLSPNSAMALAERLYIAGYISYPRTESTTYPSGYNLREIVLALKESSSTRISQCAQNLLPSSKKSSDESVRYTNPRRGTDQGDHPPIMPTGLIPHDVSSNELSLYNLITKHFLATVSPDAVYSHSSLTLQSVDMPSETFLLSITDVVDQGWKALYSATEFSSMRDNDLSDDLADESISLSKETLQAISATGATLTIASAAIKAGMTKPPGYLSESDLLGLMEKHGIGTDASMATHIGNIVTRAYVELRVTGRRRCLVPTSMGISLIHGYQLIDGDLSSPQLRASIERDVTRIAEGKIRKDVLVNQVLSKFLTKFLHFKQNIGKLEALLNAKFTSIKKAGRPFILCGECHRYTDLIEQYPPRVYCVTCDKLYTIPMRGTFIEIPSRKCPYDGWPLILHMAEATQKRTFFCLHCYTFGLNKEEALTQLQTVAADGSTDIEQTKAITCGMCLNSLCQMSLLKTQVGACWHCNADGRPMLSVNRDGPDSSPGATNDTLAVARSPEAQEQTPEKSAELASAPVQPKKISITIKPQAKISLNIPQANKSSGSASAVPSPNKASSLAELVGGYLCLDVGTARRLPGIYCNRCNFQIAFQECKLSLSSDFCACGRIKLRATDLLDKKSASSEVFGCVHCNDELFQTVSEYKDGSGRHPRRAAQPKRHGPRGRKHR
The following text describes a protein:
Function:
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MTGQSNPRFRLLIGWCCLMSSALLMMTVYLATSSNKQSETNTTTSEHHSSAGPQEKRVQFSELQALNVIDYIRLLKDKKKIWICTQPCKSKRLKLNNSSVEIASTGLYHIHAQVGFKRHESTQETKKTPQKNTINLIKNKGLSAQKKLSEVISFEPGTLRLIRLVKLKEGDSISLDINYQNQSMSLLEDEYHTYWEIILLNEI
The following text describes a protein:
Function:
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Sequence:
MPDIHIKNTRIYYNNSLRPAEILIENGKITKIGKDFRVSSSDMVIDAEGALTLPAGIDVHVHFREPGMTLKENWYTGSCAAAAGGIATVIDQPNTIPPTTDRRSFEQKLKLARKKSIVDFGINGGVTGNIEKLRELWRLGVTAFGEIFMAESTGGLNINEETFEEALAEIKKLGALATIHAEDEKMRLELEQLLKGDVSYDYHSKVRPNACEASAVQSALELISRLQVRAHFCHLSTLEAVGMIRKEKYLAKRENKKPLFTCEVTPHHLFLSAKDWERLRAFGKMNPPLRGSHSIKALVNGLNDGTIDMVASDHAPHLESEKDLDIRAAPSGVPGVETLMPLMLAAVRKNILPLSQMIMVTSWNPAKAFGLDRLGKGWLEVGFDADLMIVDPRNLQPIRADMLHSKAGWTPFEGMDAVFPEYTLSRGEVIWMEDSINAKPGRGEFLEGSGKRSEEDEEENSEETGSD
The following text describes a protein:
Function:
Master transcriptional regulator that mediates the response to amino acid starvation. Binds variations of the DNA sequence 5'-ATGA[CG]TCAT-3' in canonical nucleosome-depleted 5'-positioned promoters, and also within coding sequences and 3' non-coding regions. During nutrient starvation (low or poor amino acid, carbon or purine sources), it activates genes required for amino acid biosynthesis and transport, autophagy, cofactor biosynthesis and transport, mitochondrial transport, and additional downstream transcription factors. Activates transcription by recruiting multiple coactivators, including the mediator complex, the SAGA complex, and the SWI/SNF complex, to enable assembly of the pre-initiation complex at core promoters.
Subcellular Localization:
Nucleus. Note=Localizes to the nucleus independently of cellular amino acid levels.
Domain:
Residues 89 to 100 and 106 to 125 define the N-terminal activation domain (NTAD) and the central acidic activation domain (CAAD) respectively, which can function independently to promote high-level transcription of the target genes.
Sequence:
MSEYQPSLFALNPMGFSPLDGSKSTNENVSASTSTAKPMVGQLIFDKFIKTEEDPIIKQDTPSNLDFDFALPQTATAPDAKTVLPIPELDDAVVESFFSSSTDSTPMFEYENLEDNSKEWTSLFDNDIPVTTDDVSLADKAIESTEEVSLVPSNLEVSTTSFLPTPVLEDAKLTQTRKVKKPNSVVKKSHHVGKDDESRLDHLGVVAYNRKQRSIPLSPIVPESSDPAALKRARNTEAARRSRARKLQRMKQLEDKVEELLSKNYHLENEVARLKKLVGER
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MTNGDTSIKFPGSLNYPVEISSRLVKTGDYVKKHEPLLLYRFYGKVEEDQEDGTTQLVDRVFVEQFESPVEGELTRWIVEEGDQVNNATEPILCIKEPCSHEVHYGGLCAICGQNITNQDYMGFSDLSRATINMTHGSGGLTEARRLETETAIRLQKQKRLSLIVDLDQTIIHATVDPTVGEWMKDPNNVNYKVLRDVHYFYLREGTSGYTSCYYIKPRPGLQEFLHNVSKLYELHIYTMGTKAYATEVAKVIDPDGELFQDRVLSRDDSGNLTQKSIRRLFPCDTSMVVVIDDRGDVWNWSSNLIKVYPFEFFVGIGDINSNFLSKTIPLPRGEPEPTEKETRDENESTPDAVQEATPTVGDRTLLEENFMQSPNTLKEQSDEHMTALDKTPYSVKKALNLADILCCATMIASYFISKKVLTNIHHAYYDRLEEFQKSSSTIAQEPTADVGLIIPEMKKRVLSHCRILFSGIIPLGVDVITSDIAKWAMSFGAHVLLDLKDNPTHLVASKVQTEKVRRALEIQTVKVVNLDWLLHSMSQWKALPEENFLLYPNQILKQEAVSGPSGNDGSEISSVISESDEGEDRVTEINDRELDDIDWNEADKDVEGALGDITTDFSGDESDRSDLQNGEDEKLTPAAHMAKRRREALSRKSSLTRVLSETDSPTAKRTRHPSEGENSNSSSRAPSEGETDIDDLADLDSFANDLEADLEGQLEPEQTVA
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAEILNEIKKIPIVTRTLLGLALSVTGPVALGLVNPYYILFSTRHIFKKFELWRILTPFFFAGSGLQLLFDLFLLYRNSMALETQSFAGRTADYAWTIICLMVAIIGTNYPLKSMIFWGPLMSGLGFMWSQINPDSLVSLFGLPPFKASYFPFAMLALDYVRGGMPLMSQSLSGVVAGYGIHYLNNVYPPSNGGQRPWFMYAPAFLTRLLDGAQQTPGGGGQRLGAGTAFAARSRTWGGQAPVNPAGGTTRQAPTTTRHAWGTGNRLG