lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling. Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production. Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein.
Subcellular Localization:
Secreted.
Sequence:
MIGKSRDPSASLSSGRSGKMAGDPGRRPAPGLGWTLLLLLLRGASGDEQTAQDCPDFQNASLLRGIHLNVQFLLFTPARPSCGQPIRPDRSFEDSDFNASSDTKIVIHGFRVLGNKPSWIDQFIRTVLRARPANVVAVDWVFGSTAAYFSAVGNVMKLSLEISRLINKMLELGASPASIHIIGVSLGAHVAGMVGHFHRGQLGRITGLDPAGPEFTRASLEERLDPGDARFVDAIHTDADYLGIRIPVGHVDYFVNGGQDQPGCGFSLTAGYGYMICDHMRAVYLYLSALEAPCSLTAFPCTSYEDFLAGQCPDCSDPFPLTCPKIGMEDQGGIKMEKLPKEVKVYLGTSAGTPYCVFHSLVEFQVPHGGKRDATIEVTFFSINATSSGKVTIPRDRMWGRGVIMHPAPLCQVTRVKIRLHSFRRTWRMNEATVVVEFCTAPMPVNSEKRFCLAQPVTLKAGTSLFRQLDVACESGPGAFWPSC
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities (Probable). This CRISPR-Cas system protects bacteria against transformation with plasmids containing DNA homologous to its spacer regions; This subunit is a single-strand-specific deoxyribonuclease (ssDNase) which digests both linear and circular ssDNA; it has both exo- and endonuclease activity; ssDNase activity is stimulated in the ternary Csm effector complex; binding of cognate target RNA activates the ssDNase, as the target RNA is degraded ssDNA activity decreases; When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP. cOAs are second messengers that stimulate the ssRNase activity of Csm6, inducing an antiviral state important for defense against invading nucleic acids.
Miscellaneous:
MISCELLANEOUS: Encoded in a type III-A CRISPR locus.
Domain:
The N-terminal HD domain has ssDNase activity. The C-terminal GGDEF domain has the cOA synthesis activity.
Sequence:
MNPQLIEAIIGCLLHDIGKPVQRAALGYPGRHSAIGRAFMKKVWLRDSRNPSQFTDEVDEADIGVSDRRILDAISYHHSSALRTAAENGRLAADAPAYIAYNIAAGTDRRKADSDDGHGASTWDPDTPLYSMFNRFGSGTANLAFAPEMLDDRKPINIPSPRRIEFDKDRYAAIVNKLKAILVDLERSDTYLASLLNVLEATLSFVPSSTDASEVVDVSLFDHLKLTGALGACIWHYLQATGQSDFKSALFDKQDTFYNEKAFLLTTFDVSGIQDFIYTIHSSGAAKMLRARSFYLEMLTEHLIDELLARVGLSRANLNYSGGGHAYLLLPNTESARKSVEQFEREANDWLLENFATRLFIATGSVPLAANDLMRRPNESASQASNRALRYSGLYRELSEQLSAKKLARYSADQLRELNSRDHDGQKGDRECSVCHTVNRTVSADDEPKCSLCQALTAASSQIQSESRRFLLISDGATKGLPLPFGATLTFCSRADADKALQQPQTRRRYAKNKFFAGECLGTGLWVGDYVAQMEFGDYVKRASGIARLGVLRLDVDNLGQAFTHGFMEQGNGKFNTISRTAAFSRMLSLFFRQHINYVLARPKLRPITGDDPARPREATIIYSGGDDVFVVGAWDDVIEFGIELRERFHEFTQGKLTVSAGIGMFPDKYPISVMAREVGDLEDAAKSLPGKNGVALFDREFTFGWDELLSKVIEEKYRHIADYFSGNEERGMAFIYKLLELLAERDDRITKARWVYFLTRMRNPTGDTAPFQQFANRLHQWFQDPTDAKQLKTALHLYIYRTRKEESE
The following text describes a protein:
Function:
Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication (By similarity).
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MEEFLNNFKSYSRADQRWLSAVFEAVQQQFSPLLDSDGFSVARLAQSVVEKVQRAVGSDCADLPVSYRIVSVSELIRDQRTACCSSLCWSSAHYRDQAKKAEQTLPNYKALPRDNLLLIGFLCDGRADGKSEGEWRVRDAGGSVPCMMLKSSCLWLGRLMLFPTWNYIPQNAPGAAGYLELVDPPVCVTLEAMTFDPGGALTEVMSVRHAAELLAHSCEDQVCVCVGGQVCVVGPLLLIRGKRFFCLVLSDGGSSVALIIRELKHQYWRQCVCVGQSVWISSLRVCSLGALEGRRVLTDSCQSRLHPHTPLQESSEEQDTEDDTHTPADTTHTLADATRTPADDTRLASDPAVRVKPSTIISFKGTVTKILNAEAGLYELDGQVGLCLAYQPTQKWGGGLRPGAEIQLHNVHFTYQASAFAPRAVLWACLRSSVQITAFSRLCSELQVTEPHGALQRLLLERNLGPSQYLWLCYCQKAIAERLSPRWVRPDRVCVVAGRLLDAVCDAEQKTKKKRNIYTEMIQEPHHCPISMYCVRWPSAALWSVQQLCVWMQREVWSSLSLPALLSASAPHMTALELNSALRWSSVELRLEEASPDPLLLLGVLELQAESATLQLRDHTHKLHCLCVCRDHSPNISTAWQGCLVCVRRCTLVMERFMKTNFPSWKHLDQPSYITLKHCRVYLQLCMDDLIIISPSSSMSHQMAESKLTHGHTHRSCGESSKRLRSADAGVCERADSSAVCVSLLFRLENKHGVTLQNVSADTHTRQLGFKCRAVCVGGVQRWSHDPKNCRIQERERDGGGQTVELHFRGSCVRWFPVLHPGCVYRLIALNTEDVGVLEAKGVSARGGVTQLSSPSLLLQPQWRVHTLPEEPADAQAAAPALMSVSEVLHSSSAPEVVSFHGIISQRITLQEDNEAQPKIKSVSPTADTQEDLRVRLTVQDAECPGLMVHVYLDLSCGLYTLGLITGAALQVHHVQRKVSRACNVYCRSLPISYVSVTGLRSVCSGPAAAAPPPPMMLLGSWASVGSQQCLVAQVKGHVVCVLSLRLQWICSLCGSIFTQTTCGRTHPPCDSTSAVFQAEAKVVLEDGTGEAHVWFSSESVCGLLMLNAVQWEGLQRLVRVKGHVKVYTRGRTMTCDDSPDDSIVQYLSCLCSSVSVCRQIHVTCRRRAQKTGKSQLRKVHRGQTEFICKFPPALQLQCQHIHTR
The following text describes a protein:
Function:
Substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediates the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation. Thereby, positively regulates ciliogenesis, playing a crucial role in the initial steps of axoneme extension. May also play a role in endoplasmic reticulum calcium ion homeostasis.
Subcellular Localization:
Cytoplasm.
Sequence:
MRMEAGEAAPPAGAGGRAAGGWGKWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEAEFYNIGPLIRIIKDRMEEKDYTVTQVPPKHVYRVLQCQEEELTQMVSTMSDGWRFEQLVNIGSSYNYGSEDQAEFLCVVSKELHSTPNGLSSESSRKTKSTEEQLEEQQQQEEEVEEVEVEQVQVEADAQEKAQSSQDPANLFSLPPLPPPPLPAGGSRPHPLRPEAELAVRASPRPLARPQSCHPCCYKPEAPGCEAPDHLQGLGVPI
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MGKEMLENVKDDGGLEELEMLLNEIPQATSLNLYHGKSHHHHDVVVVHRGDDDHDRHHDSFVVSHGMCDDFTQIQYPSVSSPVSGFSLQSDGSSSSLFSSSGHALSDTGSPTPPPLEDLKSTTMPSSSHPNNRFITPDSTTLMRNANGGFVDELGGLCANLSQMYISNQQESPCDFKDASMAMHRPRPPPFPECVSFTGNGPSNNVQYHGDSYSFRRGSFDCVGGVQSPLSWTPVNHDAEINSALMAKFFGSRQCAKMSYETMLSQLHDFSSSMDHHRHSRPLLVDNYYRGGSGNQPPECTASLSRNPMVDALLNAQRNGMNVTEETGMSRSPSSSSRGINLRPYLGVQDLLQYSHSLPNYSARAVPLSNARILQGNIDAIAREESFIIQGEGVNYAASIGLDRSMYRSKAVVRDTGFARHLKRSELDVPYQVVGTYDNDRGARIGCSFPLLPKYSSLAEAQGYIYLMSKDQHGCRFLQKMFDEGTPEDVQVIFNEIIDHVVEPMVNPFGNYLMQKLLDVCNEEQRMQILLIITEEPGQLVRISLNTHGTRVVQKLIETLKTRQQISLAVSALEPGFLALIKDLNGNHVVQRCLLCLSNEDNKFIFVAAAKYCVDIATHQHGCCVLQRCIGHSNGEYQEKLIAEICANALLLAQDQFGNYVVQFILDLKIPSATACIRLQFEGNYAHLSRQKFGSHVVEKCLAVFNDENRSRVILELLSMPHFEHLLQDPHANYVVQSALRHSEGRLHNLLVEAIESHKAISRNSPYSKKIFSQKLLKK
The following text describes a protein:
Function:
May play a role in growth-suppressive activity and cell death. May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium. Plays a role in preventing tumor onset (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MCHGRIAPKSTSVFAVASVGHGVFLPLVILCTLLGDGLASVCPLPPEPENGGYICHPRPCRDPLTAGSVIEYLCAEGYMLKGDYKYLTCKNGEWKPAMEISCRLNEDKDTHTSLGVPTLSIVASTASSVALILLLVVLFVLLQPKLKSFHHSRRDQGVSGDQVSIMVDGVQVALPSYEEAVYGSSGHCVPPADPRVQIVLSEGSGPSGRSVPREQQLPDQGACSSAGGEDEAPGQSGLCEAWGSRASETVMVHQATTSSWVAGSGNRQLAHKETADSENSDIQSLLSLTSEEYTDDIPLLKEA
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
Subcellular Localization:
Nucleus.
Sequence:
MSLLTKNFRCTAVDPDGKQFDDVSRIKATTDEGDYELVLDYNCFIYEIKQDQLFQLNISTQLHSDEASRAEEHWHPSIVENSTLAASYEYIMHGKVYNYEEQPETNRATVYVSYGGLLMSLTGDRNTIAGIQRGKEVYLLISRKSK
The following text describes a protein:
Function:
Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus membrane.
Domain:
The proline-rich region is required for endoplasmic reticulum localization.
Sequence:
MAAPAPSLWTLLLLLLLLPPPPGAHGELCRPFGEDNSIPVFCPDFCCGSCSNQYCCSDVLRKIQWNEEMCPEPESRFSTPAEETPEHLGSALKFRSSFDSDPMSGFGATVAIGVTIFVVFIATIIICFTCSCCCLYKMCCPQRPVVTNTTTTTVVHAPYPQPQPQPVAPSYPGPTYQGYHPMPPQPGMPAAPYPTQYPPPYLAQPTGPPPYHESLAGASQPPYNPTYMDSLKTIP
The following text describes a protein:
Function:
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDNTRLRIAMQKSGRLSDDSRELLARCGIKINLHTQRLIAMAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEELLNRRAQGEDPRYFTLRRLDFGGCRLSLATPVDEAWDGPLSLNGKRIATSYPHLLKRYLDQKGISFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMEESKQQLIDKLLTRIQGVIQARESKYIMMHAPTERLDEVIALLPGAERPTILPLAGDQQRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME
The following text describes a protein:
Function:
Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.
Sequence:
MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRHKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSIFHGNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSIPGSDIMRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTHAYNQPEDLVYSQPEMRERHPYTVPYGPQGVYSNKLVSPSDQRNPKNNVVPSKPGASAISHTVSTPELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTRKVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGMEAMTLKSLHLPMARRNTLREQGPPEEGSGSHEVPQLPQYHHKKTFSDATMLIHSSESEEEEEEAPESVPQIPMLREKMEYSAQLQAALARIPNKPPPEYPGPRKSVSNGALRQDQASLPPAMARARVLRHGPAKAISMSRTDPPAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSIIEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPMDERFRTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRLI
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
Subcellular Localization:
Nucleus speckle.
Sequence:
MASSRASATATKTPSRTPEDTASPVVKKPHIYYGSLEEKEKERLARGESGMLGKEGIKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGSSNLKTARLWIANYSLPRAMKRLEEARLHKEIPETSRTSQKQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKLLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTISLDKKDVNLASCAADGSVKLWSLESDEPVADIEGHSVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKVWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE
The following text describes a protein:
Function:
Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
Sequence:
MIKTKSPLPMVPVSEALETVLTETAKLLWFRRQETHELGGDASSSQPPSSTTCTQSQLIGRLSAEDIKACHPGYPDHNSSIMDGYAVRTSDLDSARDVYNNTGAHGDEQTDFVLDFAIVGKVYAGDDDVTVDKAGQYNNLRTAVYITTGAVVPHGYDAVIPIEETTYLDNKMQIIPSKVRSVLNTKPGTWIRTIGCDISPGSTIVNKGEMIQPVHLALLAQAGVSLEDVKVKELVRIGVLSTGNELQQKANWGEVQNGSGKIPDVNRPLLLSQLSSYGSCEPVDLGIVSDDEGLDTIAERLNGLFWGDESEQSNTCNGSIDVLITTGGISMGEKDIMEQVFIQGMGGHVHFGRMNMKPGKPTTFITIDQETSRGEMCRKLVFALPGNPVSASVCTDLLVRPCLDLIHRGVDINNMQAGLTLSTDSFVQHAVGDAKVHDEVLATLASDVKLDNERPEYHRVALQRVLTTNTTGASQQYSFQATSTGVQRSSRVLSLRNADGLMVLPRGGPLGCGYDVAKKGMQFPVLLYSSMAETFFKDSIHRSINAAKDEVLTPSLKLGVIVCRSESQACNTIINDTLVQSLGGESQVVLMQEATCTVPSDTKMQLFIRELTNNIYGQSMGGVNVIFVVVQSDDDSDSAFRVGLEVSHVLRPIVLKNANAMAMQLRKGAVSEDGIAALFENVVGTVRVGSAVLLTCSDRGLQGAVGAVRGSLRHLATFLD
The following text describes a protein:
Function:
Involved in DNA repair and RecF pathway recombination.
Sequence:
MHYSTEAIVLKNIPYGEADLIVTYLTKNYGLLNLFAKSPRKIKSRFGSSLEPLTYSQISFIGKEDNLQKIIQSDIIHPFQTIRENYRLFLQIANALRFLIQALPKKEPNSELFYLLLNTLLYLEKRIKPDNYILFLKVRGLSILGYLPDFKNCGVCRQELKEEFYYSSGFIICKKCSSSYHYSSSALPIPISQGVIKLLKEISTWTLNFLERVKISDKLFNEMEKFLQNHIFTVLGYNKTWDTEKNITAS
The following text describes a protein:
Function:
RNA endonuclease component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS11 constitutes the RNA endonuclease subunit that degrades exiting nascent RNA transcripts. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MPEIRVTPLGAGQDVGRSCILVSISGKNVMLDCGMHMGYNDDRRFPDFSYITQSGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFITWTNQKIRKTFVQRNMFEFKHIKAFDRTFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQMLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLRQKIEQEFRVSCYMPANGETVTLPTSPSIPVGISLGLLKREMVQGLLPEAKKPRLLHGTLIMKDNNFRLVSSEQALKELGLAEHQLRFTCRVHLQDTRKEQETALRVYSHLKSTLKDHCVQHLPDGSVTVESILIQAAAHSEDPGTKVLLVSWTYQDEELGSFLTALLKNGLPQAPS
The following text describes a protein:
Function:
Has a role in meiosis.
Sequence:
MESNVNDEIEKAFAKDSELAKDIIKQYGKTKSIQPLVHRICKYINTLQKENESGQVKEAGSLKRKDRVQHELGQLVYGVLNLSFQAPMRKKLDVYIYENGIAVTLPGEPNLIEFWLPWNEIRCAIHVPCPRKANVQNNFVIILKSESSAENIVSSDNVKEPVFFTAPYPLKKLNLVEGLRSFTHCTNSWDIFRDYFEFIGTSTLSPSVEEFVCPNPQTGDNGTTYGVEANYKAKDGHLFFLRTGILWGFRKPILFIELASIQHFSYSNVLQRTFTVNFEAGGTIYSFDMVDQSVFRAVNDYATKHGLMDSSLAEEKAAPVPKNPSVSYLNEASSLENVDDMDDIDVKEPLFSDNDEDVENSDSEDGSESIGSEDEE
The following text describes a protein:
Function:
Involved in photosystem II supercomplex formation and repair, probably acting as a psbB/psbC chaperone on the stromal side of the membrane.
Subcellular Localization:
Plastid, chloroplast membrane. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side. Note=In thylakoids, enriched in stroma lamellae, and also present in grana.
Sequence:
MSLAPSSYPSLYSSPSLPRTQQTKQNPSLITQSSFISAKSLFLSSNSASLCNTHVAKRRNLALKASETESSAKAEAGGDGEEEEKYETYEIEVEQPYGLKFRKGRDGGTYIDAILPGGSADKTGKFTVGDRVIATSAVFGTEIWPAAEYGRTMYTIRQRIGPLLMQMEKRNGKAEDTGELTEKEIIRAERNAGYISSRLREIQMQNYLKKKEQKAQREKDLREGLQFSKNGKYEEALERFESVLGSKPTPEEASVASYNVACCYSKLNQVQAGLSALEEALKSGYEDFKRIRSDPDLETLRKSKDFDPLLKQFDESFINESAINAIKSLFGFNKK
The following text describes a protein:
Function:
Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.
Sequence:
MHFQAPLGPQHSSCPVSDYINRQAFLHRMNQCAAAKLDKNVTEETVKMLFSNIEEILAVHKEFLKVVEECLHPEPNAQQEVGTCFLNFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLLKELLKRTPRKHSDYTAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQAHIEGWEGSNITDTCTEMLMCGVLMKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYVFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKSPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRSEMQDVISKGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFAVGLCDNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFLRPFPEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYKRPMKQDSIQWVYDSLESAQEDIQKSHSKPPGDEAGDVFDCKVEDVMDKFNTLAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGTKCNVVEKMVEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIATDLQSKFTSMCSERVEHVCHRISSYGRFSRVLKNRAWPTFKQAKAKMSPLHSSDFCPTNCHVNVMEVSYPKASASLGSAFGVQLDSRKHNSHDKENRSADPGKLSPMVYIQHTITTMAAPSGLSLGHKDGHGLRYLLKEEDLETQDIYHKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTTEYVIPTDSDNEKGERNSKRVCFNVAGDEQEDSGHDTVSNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDSGDELPTSIRISHDKQDKIHTCLEQLFIQLDSITNLLKGRAVVRAFEQTKYLTPGRGLQEFQQEMEAKLSCPRRLRLHLKQDPWNLPSGVRALAQSFRKYVEEVKCRILLALLEYSDSETQLRRDMVFCQSLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPNLKDEQAMLEDTLVALFDLEKVSFFFKPSEEEPLVANVPLTYQVEGSRQALKVVFYMDSYHFEQLPQRLKNGGGFKIHPVLFSQALESMEGYCYRDNISVEEFQAQINTASLEKVKQYNQKLRAFYLDKSNSPPNATSKAAYIEKLMRPLNALDELYRLVTSFIRSKRIAACVNTPCSASGVGLLSVSSELCDRLGACHIIMCSSGVHRCTLSVTLEQAITLARSHGLPPRYIMQATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPVGDE
The following text describes a protein:
Function:
Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation (By similarity). The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts (By similarity). Dispensable for viability and growth but is required for protection against oxidative stress and for wild-type life span.
Subcellular Localization:
Cytoplasm. Mitochondrion. Note=translocates from the cytosol to mitochondria upon exposure to hydrogen peroxide.
Domain:
The VLRF1 domain mediates binding to the 60S ribosomal subunit.
Sequence:
MGFTLKSLEFLQGVEPFRIDENHENEGASEEEEVLISAETDAGMSLMLEWKMRLSEDSDQCTTCNCPVDFGDRAVLLEHYQSLFHRTNTLRKARNMTVYTEEDFEGIENSENDLTSSQTTIGLESDDEEFDALLLPANRSFFIKNGSVFSVPRNILHVGERDVSSVTFLRPFDCAIFLWNGGHFAAAMFENDKMTVQKSFHRYVARAKQGGVQSQHDSGGKGAAKSAGAQLRRYNEQKMKEEIQSIMSSWKSRLQKTPLLFIRCAAYHRNIFFEADAGIETRDDRIRTIPFETKRPNIDEISDCWQRLQQVSEHGAESDFRAEMLEVREKRKKLARKVAGKKRKDGGMQMICEWSDDDENEDISKEKKTHHIKVRTIKKPEETVVQWPRLDDEWRQKTYNYVRQDSVEALKEHLASLNEDVTSEANDYLRNAKIPPNRSTFLHVSAANDARKCLKYFLEEVNCDSSTKDGAGLPPYSSSANSDVKSIFIDYRVKNETAGNWARTHIPEPKKKVELTEEQEREQAERKKEKKARQKEKEKLKKEIAKRDVEEMEERQKYVNMSEREKRALAVDRRLAGLPPILRCHQCGVQLPPTPFQYSHYNFCSTSCVAEHRKANPQ
The following text describes a protein:
Function:
Specifies differentiation of the set of six touch receptor neurons. Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter.
Subcellular Localization:
Nucleus.
Sequence:
MEVLESKPLSAISMVIDAIGVEHDSQNKCYCCNEQIFDRFICRMDNRSYHENCVKCAICESPLAEKCFWKNGTIYCSQHYYKDYSAHRCAGCKKGVSPTDMVYKLKAGLVFHVECHCCTLCGRHLSPGEQILVDDTMMTVSCMSHYPLPMDDPCPPVGPSDVPSCSSDASAVAPYPMDESFPFQIKKEVDAYGYNFEHYSFSDFCDDDSRMLKRRGPRTTIRQNQLDVLNEMFSNTPKPSKHARAKLALETGLSMRVIQVWFQNRRSKERRLKHLCNYLRHYEQRGLIPPPIHFRNEEMDGTDFNSFCGNFEEEDDED
The following text describes a protein:
Function:
May have porin activity and function in peptidoglycan binding.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKAKSLLLALAGLACTFSATAQEATTQNKAGMHTAFQRDKASDHWFIDIAGGAGMALSGWNNDVDFVDRLSIVPTFGIGKWHEPYFGTRLQFTGFDIYGFPQGSKERNHNYFGNAHLDFMFDLTNYFGVYRPNRVFHIIPWAGIGFGYKFHSENANGEKVGSKDDMTGTVNVGLMLKFRLSRVVDFNIEGQAFAGKMNFIGTKRGKADFPVMATAGLTFNLGKTEWTEIVPMDYALVNDLNNQINSLRGQVEELSRRPVSCPECPEPTQPTVTRVVVDNVVYFRINSAKIDRNQEINVYNTAEYAKTNNAPIKVVGYADEKTGTAAYNMKLSERRAKAVAKMLEKYGVSADRITIEWKGSSEQIYEENAWNRIVVMTAAE
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MDSDVEMNAASDEEVMDDEDYYDYCYSDVGDDGDGGSEEELVPVDYDEGLEAEGTDEVVSRREQTFVVLNEEVISERQEEDVSKVSAVLLITREEACALLHHYKWNISKLSDEWFADEEKVRHTVGLLLNGNHEPGSRKLTCGICFEGYSSDTMSSAGCAHFYCHECWEGYISAAIGGGPGCLSLRCPDPSCSAMVLQGMVNELAKDEDKAKYARFLLRAYVEGSKKTKWCPAPDCTCAVEFLGDENYDVSCNCKFSFCWNCTEEAHRPVNCETVSKWILKNSAESENMNWILANSKPCPKCKRPIEKNQGCMHMTCTPPCKFEFCWLCLGAWSDHGERTGGFYACNRYESAKKEGVYDETESRRERAKNSLERYMHYYERWASNQTSRQKAQADLLKAEKDQLANLTYIYGIPETQLKFIIEAWSQVCHHRFVLWFQCVFQFTNLLISDAFTTAVHQIIECRRVLKWTYAYGYYLDDKVKSDFFEYLQGLLFLFHVDIINGFIIPCGNPWNILESNYLTGEAESGLERLHQCAEKDLHNFLTPVKFESTETTTPTVAEFGEFRVKLAGLTSVTRNYFENLVQALEAGLEDVHATAQAAGTSIAGTSSKKGGTKSKKKQHTKPSSDHTDDGWPCERCTFLNPPSVVVCSVCEKSRY
The following text describes a protein:
Function:
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway.
Subcellular Localization:
Secreted. Host cell. Note=Secreted via type IV secretion system (T4SS), and delivered into the host cell.
Domain:
U-box 1 is critical to the ubiquitin ligase activity, and U-box 2 mediates interaction with host target; The 25 C-terminal region may carry the signal responsible for translocation into the host cell.
Sequence:
MATRNPFDIDHKSKYLREAALEANLSHPETTPTMLTCPIDSGFLKDPVITPEGFVYNKSSILKWLETKKEDPQSRKPLTAKDLQPFPELLIIVNRFVETQTNYEKLKNRLVQNARVAARQKEYTEIPDIFLCPISKTLIKTPVITAQGKVYDQEALSNFLIATGNKDETGKKLSIDDVVVFDELYQQIKVYNFYRKREVQKNQIQPSVSNGFGFFSLNFLTSWLWGTEEKKEKTSSDMTY
The following text describes a protein:
Function:
Involved in the breakdown of propeptides of storage proteins in protein-storage vacuoles.
Subcellular Localization:
Vacuole.
Sequence:
MSGGKKYEAHALLTSHTTPHQMRPASALLHIQKLIGICLGTCTNSHPGHGTPLSSSNGRSHSTTKSDGQPPLYTLPTTPPLRSAAHVSCSSTFPSSCSCPRFLIATMGTRGIALVLLAAALLQALLPASAAAEGLVRVALKKQPIDQNGRVAARLSAEERQRLLLRGANALGSGSDDCDVIALKNYMNAQYFGEIGVGTPEQKFTVIFDTGSSNLWVPSSKCYFSIACYFHSRYKSGQSSTYKKNGKPAAIQYGTGSIAGFFSEDSVTLGDLVVKDQEFIEATKEPGLTFMVAKFDGILGLGFQEISVGNATPVWYNMVKQGLISDPVFSFWFNRHADDGEGGEIVFGGMDSSHYKGDHTYVPVTQKGYWQFNMGDVLVDGVSTGFCAGGCAAIADSGTSLLAGPTAIITEINEKIGAAGVVSQECKTVVSQYGQQILDLLLAETQPAKVCSQVGLCTFDGTHGVSAGIRSVVDDEAGKSNGGLKSDPMCSACEMAVVWMQNQLAQNKTQELILNYINQLCERLPSPMGESAVDCASLGSMPDIAFTIGGKKFKLKPEQYILKVGEGQAAQCISGFTAMDIPPPRGPLWILGDVFMGVYHTVFDYGKLRVGFAESA