lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in rRNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAPKRKLSDSDAPEVVHPSRQVQVYGDEPKPAKKRKSEPAFNKKQAHASSVNTIKKKIRDTTRKLERAQDLPADVRVENERALAAYQQELASAEAEKIRQKMIKKYHMVRFFERQKATRQLKKLRKRLLETQSTEEVEQLKEEMHILEVDLNYTQYHPLSETYISLYPPKGSKEDAEDKADKEKPPMWKEVEKCMEEGTLDRLRNRKPDITISTTKPVKLPERKSIKHKPVPKPKLEEQAPSIDTTGMNRRQRRAQRGVKDSRATKIAKNKSTGFSKNQAFGAVEGARADEAQDGNVSDGGFFEE
The following text describes a protein:
Function:
May play a role in apoptosis. May act as a tumor suppressor.
Sequence:
RSQNVILMGLDSSGKSTLLARLLTGKVVTTSPTVGFNVGTLNLDKKTSLTLWDVGGQKNMRPNWRLYLDNCKALVFVVDSSDTARMAEAKKALKMVLSDKKLEGVPLMVLANKKDLPNSMKIREVSTLLDLESYKDLQWEIQACSAVEGLGLQQAFLSVHRMIKKS
The following text describes a protein:
Function:
Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release. Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids. Essential for mossy-fiber long-term potentiation in the hippocampus.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.
Sequence:
MAVDVAEYHLSVIKSPPGWEVGVYAAGALALLGIAAVSLWKLWTSGSFPSPSPFPNYDYRYLQQKYGESCAEARQKRVPAWNAQQASTRGSSSRKGSLSIEDTFESISELGPLELMGRELDLAHCGTLRKSQSADSLNSISSVSNTFGQDFTLGQVEVSMEYDAASHTLHVAVLQGKDLLEQEEASFESCFMRVSLLPDEQIVGISRIQRNAYSIFFDEKFSIPLDPTALEQKSLRFSVFGIDEDERNVSTGVVELKLSVLDLPLQPFSGWLYLQDQNKAADAVGEILLSLSYLPTAERLTVVVVKAKNLIWTNDKTTADPFVKVYLLQDGRKMSKKKTAVKRDDPNPVFNEAMIFSVPAIVLQDLSLRVTVAESSSDGRGDNVGHVIIGPSASGMGTTHWNQMLTTLRRPVSMWHAVRRN
The following text describes a protein:
Function:
The S-layer is a paracrystalline mono-layered assembly of proteins which coat the surface of bacteria.
Subcellular Localization:
Secreted, cell wall, S-layer.
Sequence:
MAKTNSYKKVIAGTMTAAMVAGVVSPVAAAGKSFPDVPADHWGIDSINYLVEKGAVTGNDKGMFEPGKELTRAEAATMMAQILNLPIDKDAKPSFADSQGQWYTPFIAAVEKAGVIKGTGNGFEPNGKIDRVSMASLLVEAYKLDTKVNGTPATKFKDLETLNWGKEKANILVELGISVGTTADKWEPKKTVTKAEAAQFIAKTDKQFGTEVAKVESAKAVTTQKVEVKFSKAVEKLTKEDVKLANKANNDKVLVKDVKLSEDKKSATVELYSNLAAKQTYTVDVNKVGKVEVTVGSLEAKTIEMADQTVVADEPTALKYTVKDENGTEVVSPAGIEFVTPAAEKINAKGEITLAKGTSTTVKAVYKKDGKVVAESKEVKVSAEGTAVASISNWTVAAEKADFTSKDFKQNDKVYEGDNVSVQVELKDQFNNVVNNVKAEYESLNTEVAVVDKATGKVTVLSAGKAPVKVTVKDSKGKELVSKTVEIEAFAQKAMKEIKLEKTNVALSTKDVTDFKVKAPVLDQYGKEFAAPVEVKVLDKDGKELKEQKLVAKYENKELVLNAHGQEAGKYTVELTAKSGKKEVKSKLALELKAPGVFSKFDVRGLENELDKYVTEENKKNEMVVSVLPVDANGLVLREKEAATLKVTTTDKDGKVVDATSGQVAVNDAAGTITVGNEAKAGETYKVTVVADGKLITTHSFKVVDTAPAAKKLAVDFTSTSLNEVAQGSELKTALLNILSVDGVPATTAGATVTDVKFVSADTNVVSEETAKFGTKGSTSIFVKELTVKKGEQTQKVELDKPVRVDVSIKEVKEVK
The following text describes a protein:
Function:
mRNA stabilization factor specific for the 0.95 kb OLI1 mRNA. Also involved in OLI1 ring formation.
Miscellaneous:
MISCELLANEOUS: Present with 2430 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MNKFCLLPFHGKRIGVANIPFTILFKKGPYFLHSHITAVYYSTKGKNDSHEQSRVSKKSTFTPLETPWYLRIVDNEKELMEGKKNNHHTMNKELEIPKTSPNSLRKIADLLTGKLGLDDFLVFDLRKKSPNSVSAVNKLGDFMVICTARSTKHCHKSFLELNKFLKHEFCSSAYVEGNFNERQESRRKRRLARKSNLSKLLGRSSECSAKDLNSEAWYMIDCRVDGIFVNILTQRRRNELNLEELYAPENEKSKFQNIDSGNVPTISGVNEISSNNNILLGLRRLAQQRRRYSTINPNGLSNLRYFLQKEDFKGANKIIQSSSGTETHNIRTLEHVKNTLKDLVGQERKVDVVQWKSLFDEHSTFLTINQSAAYWPLRLEYAILLNKADPQFYSDRVFLKDYLLLKKSLGQELIREDLIALLEMVLKTQHSSHSYFNLVKQNRVIIRALNLFKGLQTEDDGSVVYDEVVISLLLNSMVADERVKLRSLYETIDHIFQTFGDKLTSGMIVSILQNLAKIKDWNKLLQVWEAITPTEGEGQDKRPWNEFINVINQSGDSHVISKIVNNGHLLWIRRLNVNVTPELCNSIKALLKTAGMENSTLEEFLVRGTNNQ
The following text describes a protein:
Function:
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLVKRNIEPRHLCRGTLPDGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEANNFYIRTDSLQDRIDRLAVKVTQLDSTVEEVSLQDINMRKAFKSSTTQDQQVVSKNSIPRPVRDIYKTCDRPPPLDILSKYRDDKKDSLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQKEQKQVDGTTREVKKVRKARNRRQEWNIMAYDKELRPDNRLSPNVFQAASSEGSLSPDTRSHISDVTEYSYPATPNHSIHHPMTPTYVGSVEPQHHMGSSQANDHDYRSASGTLRHGTLNRPQQPPPPPPAAVDGTSPVPIVSANGRRVLPPQMMEYYPTGSPPPPPPLIPSAQTAFVSPLHHTLPSSPAAQISGSAYAPSPPPGGIITSASPGPPPPPPPPGPPAFAQSLTSSPMHFARVLEAKRLDGAQLLGLTSDARSDLLSAIRMGIQLKKVQEQREQEAKRETVGNDVATILSRRIAVEYSDSEDESELDENDWSD
The following text describes a protein:
Function:
Essential for magnetosome formation; required for stable accumulation of MamB. May nucleate iron crystal formation (Probable). Probably binds and transports iron. Binds divalent cations, possibly up to 3 Zn(2+) per dimer in vitro, probably iron in vivo (Probable). One of 7 genes (mamLQBIEMO) able to induce magnetosome membrane biogenesis; coexpression of mamLQRBIEMO in a deletion of the 17 gene mamAB operon restores magnetosome vesicle formation but not magnetite biosynthesis.
Miscellaneous:
MISCELLANEOUS: This bacteria makes up to 60 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)); MISCELLANEOUS: Expression of just the minimal mamAB gene cluster (MGMSRv2__2365 to MGMSRv2__2381), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles; MISCELLANEOUS: Cation diffusion facilitator (CDF) transporters all have similar domain structure. By recreating in MamM mutations known in paralogous human zinc transporters (Znt-8, SLC30A8 and ZnT-10, SLC30A10), information about the effects of these mutations can be learned.
Subcellular Localization:
Magnetosome membrane; Multi-pass membrane protein. Cell inner membrane; Multi-pass membrane protein. Note=Localizes with magnetosomes in a straight line running through the center of the cell.
Domain:
The C-terminal domain (CTD) is probably responsible for hetero- and homodimerization; it assumes a V-shaped, dimeric metallo-chaperone-like fold that can open and close. Val-260 forms the hinge between the dimers. Binds up to 3 divalent metal cations (probably iron in vivo); upon binding there is a conformational shift to a tighter dimer (Probable). If the CTD cannot fold correctly the function of the whole protein is decreased, suggesting the CTD confers functionality on the transmembrane domain (TMD), perhaps activated by ligand binding to the CTD (Probable).
Sequence:
MRKSGCAVCSRSIGWVGLAVSTVLMVMKAFVGLIGGSQAMLADAMYSLKDMLNALMVIIGTTISSKPLDAEHPYGHGKVEFILSMVVSVVFIVLTGYLLVHAVQILLDESLHRTPHLIVLWAALVSIGVNVGMYFYSRCVAIETNSPLIKTMAKHHHGDATASGAVALGIIGAHYLNMPWIDPAVALWETIDLLLLGKVVFMDAYRGLMDHTAGEAVQNRIVEAAERVPGVRGVIHLRARYVGQDIWADMIIGVDPENTVEQAHEICEAVQAAVCGKIRRIESLHVSAEAREIGDTTKPSFSDQPLSFDEVMLSKVDN
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Regulates global growth and development, including phyllotaxis and apical dominance. Required for pollen maturation. Promotes (pri) miRNA transcription of each MIR159 genes.
Subcellular Localization:
Nucleus.
Sequence:
MAEVSLGMLIDIVDEEWMRDTLPDDDLPLPPVLAVKTDDTEETNQETQQADAETWRDLALDTQ
The following text describes a protein:
Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSRAGFDKYITVFSPEGSLYQVEYAFKAVTYAGLLTVAIRCKDAVLVFTQHSVPDKLMRPETITSLYNVNDNTGVCITGRAPDGKALVQKARNEASEYKYRYGMPMLVSVLAKPWQDMAQVRTQQAGMRLMGTIMTFVGMEQNDEDGAWIPQIYCVDPAGGAAVHACAVGKKQIEACAFLEKKQKNAPFHTLSQKEAAMIALAALQSALGESLRASGVEVGRCTADDHHFLRVSDREVKKWLTPLAKPGYRAAYVLVRHTFHVVNP
The following text describes a protein:
Function:
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MKSNKKSNRLRAIYRALVIAIGLAVIIVFNYFNRKNNNARSSRRACSCFFSLTGVNLEKIGTFDTDAKLIVLNHQSLLDIIYLEAYHPRNICWIAKKELGEIPFYGHALTDTGMILIDREDKKGIVSLLKACKEKLDQNRPLVIFPEGTRGKGGEKFLPFKQGAKIIAEKFQLKIQPMVLINSIKIFNSKPLEAYKARTRLVMLESYTPDFNSPTWYEELQERMQKEYLKHYHELNPSEQ
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MNHNNNTYHGRSSSPPQARELCNLLNCFLSHPIYNDSTLPLNENSQKKNNTSTTSNQTVSLSAAGMRALIYQLQSIYLRTPIKLFRPSRFDYLAYVRALANKHDNIENKPYRFMTHSSLGMIINVVRKQGWKFIPDQILPPLIANSATGVILYATYLTTLDYYTKQHEKNKVESHTTTSGGGGGTATTTTTTSRANFNWYAPIDTWRAGFVAGAVQSLAAAPVDAIYTRSTVAEMLEGSHENLWVFGFNKLREIGLIGVFAGYGFSLVKESFGFAFYFSTFEIIKTQGYNLTYKLITYYKRSEQLIKSNLKKIFHWDDDKIDEKLEKLEKYRSMKILKSSFILIAGASAAFSLLAVQYPISKVQKIHLSRLEALDVYNASRFVGNTSPFFKLYYNSYVDTYKQVLRMKQRANITWFEAAYSGFVRNALTTIPATSIALLVFEIMRTKLSDNFEDYNDVLEA
The following text describes a protein:
Function:
Involved in P-body formation. Acts as a functional homolog of human EDC4, which plays a role in mRNA decapping in the process of mRNA degradation. Enhances the decapping activity of dcp2. Together with edc3, acts as a scaffolding protein sufficient for the phase transition of the components of the 5' to 3' mRNA degradation machinery to form P-bodies. Intermolecular interactions between the edc3 Sm domain and at least 10 helical leucine-rich motifs in dcp2 and pdc1 build the core of the interaction network of this spontaneous clustering process.
Subcellular Localization:
Cytoplasm, P-body. Note=Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.
Sequence:
MNEQDLLNSLRRDLNLPNLGKSHDGSEAVESTFPEKKESSLSAQQPHVDDQRSSLLSLLNAGLNASNQSPSNSGPKYYASHSSSTDALLQAFRDGAKPSGTASGADVKRSDSESTEATSNERPFNPVSAANLERLLMSSTGPQTPINGELKSNDSQDTAFQSSRNMPSDTSVASPDYSHSQSSSPIANYQESGNSEEPHKAEEQQQLSIYQLDNPGSGNYVWETVISPDKFETSTFAKCERNDIAIINRELDAQDNQLIHTNEDFIAYAVHREPIIRVIEISTGKSFLLHNNSPNKFVSVAWGNDSVIKNRLMAIDTTGQVLIFAVDIATSTSEIIFQLSGAQSLSDPIKSRFHWYPKSSTRFAVALSKHIIFFDLDLLNNISFPIPRSINAIQQLPCFLIDTGISAKEYDFSYDGTVFATVDKDALIKIYTVPTTFPSTPDKRPVPSEVSPIAIFTTRMERGPSKNYEKPINLRFISTPGTNNSRYLVIVYVMNQLITLFDLYSKRNIQTFRFNNRPTAATTTSFSQFSVDNERSTLLVGNPPSNSIYFFLFAKDETVSEQAPIYNSTYELILASLNTSEPVPADAKFSVIVAKKFEKAACISFTACKILESEDKYCIVVSNTDGYEYYSIPTSILDKTGKTVRSLESVQNYDADIGGTIDLTERHSTASPSTVNSGFSTPRSQATGFSKKKKDKGERFETKDKSSSVLSPSSYSASTFDAIPMDSIVSNILASLEKSVHKNYESLRSQLLEYKAANEKHTEAILSVVSSTLTENTGKILESVVEKSMQVALKEEIANSVRNALKNNLEKIESFLENSIAELQNSVREDFDKQTSSLAQLRYSIQNVAHAQKESEVKYNELNEQVKTLEGYVETVLEKFNDLKIENKVPETAPDVVPSSYPPAAESNVSVSSDTSTKDVEKQEPSSAEQPAQGIAESLRRLKEYVKAGSVKECVAEWCNMPSVAGFDVLSEISYDRMLENCSNLLLLTFIYHISLLDSVDDDRLSKRMEYISRICLNIDVNDPKVETVVHPVLTLTREALLRQSEFFSPIFKRRLVVLLRALDGKISEISVASSN
The following text describes a protein:
Function:
Required for male development. In XO (male) animals, fem-3 directs male differentiation in all tissues. In XX (hermaphrodite) animals, it specifies the first 80 or so germ cells to be sperm. Negatively regulates male development when bound to tra-2. Together with fem-2 associates with the CBC(fem-1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of tra-1 (By similarity).
Sequence:
MTCDDFRAEDEQPIEVDERRRRLKRKANDDDDDDETVRERVDDAESSMEVFEAEYPPILDPLQDQREAKYFRERMQRFDLYSRTTGLSVDDIDWPLIRGRSLQKGRVAGISFVYDDTRYPINRFSDTWLLCVTKQKLFSFGAGCVEDLNITSFVLRRTMKVLSTYCNWLFEAAKRNNRRHITHKEIQELINRDGFRFHQYLQKFLIGRGMEYTEYNNRFFKYLHEEYNKNPGGLETIYSNQDFIAKETAQANYIYDTVRAKYGGFEELPLFRHALKISFTQPGEHYFSRFYAKRFHEALGCPPLDSEIIMILDWFGVLIMNQIAYKTIRWHEEEYNDGSFPVLDSYHKALADESKCPKACLISISLFPDDPLFDLDIDYGTNPPPVNTAYQKVRRTPRDPTPFYRLMEFEDYKSCLVKMHFNFSELTGEWLRKICARGR
The following text describes a protein:
Function:
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
Miscellaneous:
MISCELLANEOUS: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
Subcellular Localization:
Cytoplasm.
Sequence:
MQPTTEPHNAILVEKTPLETYVPPAKPSLIGLSRNELADRLGEIGVAPAQRKMRVQQLWHWMYFRGAQNFDEMTSISKGIRAELAQHFTVDRPEVVAEQISNDGTRKWLLRLPSGDNVEKAHEVECVYIPETDRGTLCVSSQVGCTLNCSFCHTGTQRLVRNLTAGEIVGQVMVARDRLNDWADREDGTRRVTNIVMMGMGEPLYNFDAVRDALLIVGDNEGIGISRRRITLSTSGVVPNIVRAGEEIGVMLAISLHAVRDELRNELVPLNRKYPIKELLQACRDYPGASNARRITFEYVMLKGVNDSLDDAKLLVKLLKGIHAKINLIPFNPWPGTAYECSDWDQIEKFSEYIFNAGYSSPVRTPRGRDILAACGQLKSETEKLSARERQTLRAMAMTD
The following text describes a protein:
Function:
Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.
Subcellular Localization:
Membrane raft.
Sequence:
MPVQGSGAMDVEGVTDFRALRAKFQHDSSIATKPVQLCQKPSPRLGSGGSGVPRPMPNSKADVLVPGSHSAQRAKMGHTEPMEHNEEHKGNVSVKGLSSPKSSSPKQPVSYCTEQQASVQADPEDAPLLNSFHHALQMWQNTLSGGEKASTDLPARRAMNLYVQPSPGQRVLRAPATSNGSKVPPVGSHPEPARPAQGLTSAQATQGDEKGAGSSAATTLQPQCQKESKPPLCQPGAGTQLGNKPPKIRPLPSAASLGPAPRKPLRPPKVDLSSFRSTVPSVHRQNETTAEEEDYLIPESTQCEEQHNYEKTLMYLNQSEDTTTLRVIEVPKVEPQEHKKQKSFLFGESSPGRAIIEDEKEGKTSLEREKLEVKKPGGNEYIILSGQAREDDRGGMKVSHMRQDVTSTPQRLAKDRAKPLYYGAPKPTEDRPTSSPNHHQLLLTPDNVYDDVEGLQDRLSRASDASSPSASDIRSNYEETYEDVETGSDNPAKEEAEKQKRFGKLFKIEKLKLKNTRFKENLRLFSMSVPNLADVSQEDMVYDDAETEQKDPREKDDKHKTWMPKFLMAKEAKDRRKSSDDVERSIFKVKKSNAEKNKMEKEEKIFRETFLYDKEIRVINTATAACSIPSKRRADLPLTAGEQLDVIDVTEGSAVICRNSEGRYGYVLVEYLNFRQY
The following text describes a protein:
Function:
Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that acts in conjunction with ALPHA2 to repress transcription both of homozygote-specific genes and of genes necessary for the white-opaque switch, a prerequisite for mating.
Miscellaneous:
MISCELLANEOUS: The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA); MISCELLANEOUS: Most C.albicans strains are heterozygous at the MTL locus and do not readily undergo white-opaque switching and mating, but mating occurs in hemi- or homozygous strains. Mating takes place in opaque cells, produces tetraploid progeny and seems to occur rarely, if at all, in nature. Conservation of mating capacity is rather thought to be due to the simultaneously regulated white-opaque switch, which seems to play an important role in host commensalism.
Subcellular Localization:
Nucleus.
Sequence:
MNSEIESSLTLLKSVEKLVQATSVYKNEDNEEIFLQLKRERQENSNSHEETETLFHESLDRLMKLSSIAGSKVQYELSLNNLYNLLLRTRKQEEEEAFIFPTVSTEEFALEQITFEVSDQMDDDKDSEDDILIKGEEIKKSKKKRQRLDNSTKEFLEKVFEKNKQPNRRERELIAEKHGVSLSQIRVWFTNKRMRKKEPKSKAKSSSNST
The following text describes a protein:
Function:
Beta-glucosidase involved in the biosynthesis of ipecac and benzylisoquinoline monoterpenoid-isoquinoline alkaloids natural products, starting by the condensation of dopamine and secologanin, and including emetine and cephaeline, drugs used both as anti-protozoal (e.g. treatment of ameobiasis) and as emetic agents. In response to pathogen and herbivore attack, triggers the release of toxic ipecoside aglycon to trigger defense responses. Catalyzes deglucosylation both on (1S)-diastereomer and (1R)-diastereomer substrates, including ipecoside, the main alkaloidal glucoside. Also active on N-deacetylisoipecoside, 6-O-methyl-N-deacetylisoipecoside, 6-O-methyl-N-deacetylipecoside and N-deacetylipecoside.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSSVLPTPVLPTPGRNINRGHFPDDFIFGAGTSSYQIEGAAREGGRGPSIWDTFTHTHPELIQDGSNGDTAINSYNLYKEDIKIVKLMGLDAYRFSISWPRILPGGSINAGINQEGIKYYNNLIDELLANDIVPYVTLFHWDVPQALQDQYDGFLSDKIVDDFRDFAELCFWEFGDRVKNWITINEPESYSNFFGVAYDTPPKAHALKASRLLVPTTVARPSKPVRVFASTADPGTTTADQVYKVGHNLLLAHAAAIQVYRDKFQNTQEGTFGMALVTQWMKPLNENNPADVEAASRAFDFKFGWFMQPLITGEYPKSMRQLLGPRLREFTPDQKKLLIGSYDYVGVNYYTATYVSSAQPPHDKKKAVFHTDGNFYTTDSKDGVLIGPLAGPAWLNIVPEGIYHVLQDIKENYEDPVIYITENGVYEVNDTAKTLSEARVDTTRLHYLQDHLSKVLEARHQGVRVQGYLVWSLMDNWELRAGYTSRFGLIHIDYYNNFARYPKDSAIWFRNAFHKRLRIHVNKARPQEDDGAFDTPRKRLRKY
The following text describes a protein:
Function:
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus envelope.
Sequence:
MLWFQGAIPAAIATAKRSGAVFVVFVAGDDEQSTRMAASWEDDKVTEASSNSFVAIKIDTKSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSVSADELVTRIHKVRQMHSLKSEALVANGSQSESSVSTPSASFEPDNTCENSESRNAELCEIPPTSDTKSDTATGGESAGHATSSQEPSGCSDQRPAEDLNIRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSSGDIWTLLGTVLYPFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREPVRKRVLEKRGDDFKKEGKIYRLRTQDDGEDENNTWNGNSTQQM
The following text describes a protein:
Function:
Transcriptional activator.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSTGFSAEQLVQQILDSHQTKPPPRTHNCLCTGNLGAGSSLHHKCNSAKHRIISPKVDPRAGGAYSSTHSEVQNNDVSEGKTEHSHSGGKNGRAGGDGAAGAGGREKRNGKVHKPALLHQNSMEVSSTNQVEVPDTTQSSPVSISSGLNSDPDMADSPVVTGMGHVASVMSSLSQSATVFMSEVSGDPVYSMSPTVDPNAHLLGPDPASSSLVLAVTAESHKFAFANAVGLADPASADGLGMLTTAGVSEELVLSSNLETGSIKLPETNMNFDPDCFLNNPKQGQTYGGNGMKTEESNGSSCSNGMRCSPPLGDNGYSFNAALVKNIKTEDTSFEQQLAKESGYQVGDAIGAISASSSTNSGQNSLALTPTGSLLPSGGGLSPSTTLEQMDFSAIDAKQDYPASVIAAASYSQTHLAHQSHSPSFFLQGSPQSQNHQNNSVSTQNSHDSNAYMGLSVVKTDSSGTNGDFHHHHHTLTNQHTASNCNGGSPTERNNGQAGSLQILQYQNRFASTGQEHEEMSGLEQSTGAEQEGGGIQEKDSDGRMKQGDHLQTGEAEGVGGAEHYLQQPTETGGVGSGGTSARETGNLCNDTDNNTSNSSHQQLLQGAGLVPGLFSAVGAHQTLTSTGTNGGGSMEINLDHFDVSFGNQFSDLINDFISVEGGSGTGVVPGSNALYSHQLITHSGTEGQVSSGTAAQQGGDEGAHGARGYNSAELCLQPCCSPQSSQSGAVAAEAGQLAYMQVAEAVSAAVAHGNMGMLQATGRLFVVTDYSPEWSYPEGGVKVLITGPWQEASSEYTCLFDQITVPASLIQPGVLRCYCPAHDTGLVTLQVAASSQIISNSVVFEYKARALPALPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMAGQQQQQGGGGTSESGGTTTGEGGRSNSEQAQFSPIQGQSQGQAPAGSSFESRVVVVCEKMMNRACWAKSKHLIHSKTFRGMTLLHLAAAQGYTTLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHMEAAVVLYKWDRRALAIPDSLGRLPLAIARSRGHTKLAECLESLQREEQQSGALTTTPSMPFSPSTEASAAEGWMNVWGAEATSVGLKESNIASSASSSSSDLRRPRSEPSSFYSSVNHGDAPLSKKHKPNPETLQTRPSKSCSAPLGLEEHSHKPKTCPSKPRDSAVEKEQGDGEQSQNKVGSTCGGGRWGSRQAAGRRVSTTGLGKERLANRLRLREIASAGTISDLRTSQEDLENTGDLQNMNMMTLAEEVIEATSDRIKRENFVASDTSLDGVGVSSTMSWLASYLGDAERFLFNKPLTSSPGLGTVHGGAQPELDGPLGKLGIQSPAEWTALLNASHNKEERDLTQLALSDPEQRELYEAARQVQNTFRKYKGRPLREQQELAAAVIQRCYKRYKQLTWIALKYALYKKMTLAAILIQSKFRSYHEQKKFQQSRKAAVLIQQYYRSYKELGRPNPRSRATAAALVQHKLRSSLLTKRQDQAARKIMRFLLRCRHSPLMDHRLFKRGERIEKGQGT
The following text describes a protein:
Function:
Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis.
Subcellular Localization:
Nucleus.
Sequence:
MAERGNMSKSRKARAKHSGNFQVSDLNSEDAAKRRAALEIAVKRKIESEKRALQIVERLLEDDVSEVYLLDSAKYIAPAHYKDTVEERTIIQLCGYPVCQNRLENVPKQKYKISTKTNKVYDITERKCFCSNFCFRASKYYEAQLPKTPVWMRDGESPPDIKLLKEGKSGHSGIEVKLSERCIKESEIEKLSTFTEEYDPNSPGSDSDGQGDNEQAFVSSVISSSNDTKKVGKKNSINLEKAHNLAHSLTETVESLHKCNLSDQEIMSNSKIPNCPKSVESSHNVQSNSEMLGLTHRAVSKKGAEQLRKILRNSTQYQTALKEGISPGAAKGGMLEVLTQTLNEWKTEETLKYLFGANYVIDSSFHKKDSVRSRVEVEDLDEDDLSFDPNKVSSLNESLPFHETRNPAKVVPDYEKLKEKACMQQIRVKDFFHGHYILPEDMEYKINEGKETRNKETDTLWTPALPLVDSCSQQQIRRRIVLEKLKKVLPAILLPLQMTYSEVAKELHNLVTTLRFSNKNITHTIPEWSIIAIVLLSVLLPSMPLHKDSQTNPLYTQFVSKLLEELHFQNEDLERLKERFACNHM
The following text describes a protein:
Function:
Transcription factor regulating the cell cycle specific transcription of a spindle pole body (SPB) calmodulin binding protein SPC110. Required for full induction of SPC110 transcription in late G1. Binds to DNA consensus sequence 5'-[AT]AA[TC]AAACAA[AT]-3'. Dosage dependent suppressor of calmodulin mutants which have specific defects in SPB assembly.
Miscellaneous:
MISCELLANEOUS: Present with 358 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MMNEDISIIDGHNSFLTEKSTVLLTQAKRTLEDEKEMITPPSSTVRKTMKEVNKRPSHPLSPDHSSPIAPSKAKRQRSDTCARSNGNLTLEEILQSLERRRINGELAKKPPYSYATLICLAILQSQEGKLTLSQIYHWIHVHFPYYKQKDASWQNSIRHNLSLNDAFIKTEKSCDGKGHFWEVRPGAETKFFKGENRGYEFVKDSLQDIGKYFEIDSTLDELEQVESGEGNDDLPDEEEREEAGKFPSIEIQLNSSPILRVSQLHHIPQLKTDNSVLNPHENLESMRNMIENDVNNIDSLEPPYVMKKYHTSLGLPSLVNAKDHFQAGVKNNNITQANRFNTLPITSAKSPQNFRKYFTSFNSNFEDLSPLRSNVGAGSLLDPLPYSPLKLYDQKNLALMSKPQSQQSYSNSQLPPPPSSHGSDLLKTPKMRHSDGLEKTPSRLISTPKDGNSILRKWQTPSHLFEDLYCSPLFRAIETPIRYITTPGGTLETQISPRKSSAPDVLTSATNSKFASSGLFGVDVYSVWKRATEKISDGNNTTDSNQKHHPYHNHPSNDSGNEKN
The following text describes a protein:
Function:
3'-5' exonuclease.
Sequence:
MGMATYAVVDLETTGNQLDFDDIIQIGITFVRNNQIIDTYHSMIRTNLEIPPFIQALTSIEENMLQQAPYFNQVAQEIYDKIKDCIFVAHNVDFDLNFIKKAFKDCNIQYRPKKVIDTLEIFKIAFPTDKSYQLSELAEAHGITLANAHRADEDAATTAKLMILAFEKFEKLPLDTLKQLYYLSKQLKYDLYDIFFEMVRQYDAKPLDKSYEKFEQIIYRKQVDFKKPTTNYNGSLKSLYSKAVDQLGLTYRPQQLYLAETILDQLMHSEKAMIEASLGSGKSLAYLLAALMYNIETGKHVMISTNTKLLQSQLLEKDIPAMNEALNFKINALLIKSKSDYISLGLISQILKDDTSNYEVNILKMQLLIWITETPSGDIQELNLKGGQKMYFDQKIETYVPARHDVHYYNFIKRNAQNIQIGITNHAHLIHSDVENSIYQLFDDCIVDEAHRLPDYALNQVTNELSYADIKYQLGLIGKNENEKLLKAIDQLEKQRILEKLDIAPIDIFGLKASMNEIHELNEQLFSTIFTIINDSDVYDDDIHRFHNVFTFETKDILKDLHAIIDKLNKTLEIFNGISHKTVKSLRKQLLYLKDKFKNIEQSLKAGHTSFISIKNLSQKSTIRLYVKDYAVKDVLTKQVLEKFKSLIFISGTLKFNHSFEAFKQLFNKDVHFNTFEVNTSLQSAKNTSVFIPSDVASYQYKNIDEYVASIVSYIIEYTTITSSKCLVLFTSYKMMHMVQDMLNELPEFEDYVVLTQQQNQNYKIVQQFNNFDKAILLGTSTFFEGFDFQANGIKCVMIAKLPFMNKHNAKYWLMDSEFTSTFKEYVLPDAVTRFRQGLGRLIRNENDRGIIVSFDDRLINSNYKNFFEQTLENYRQKKGDIQQFGKLLRQIQKKKK
The following text describes a protein:
Function:
Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.
Subcellular Localization:
Membrane.
Sequence:
MYVSTPIVHVMTSTAGSVAGRNAVSFAVLARTHQHPYNALPSSSRRAFSTSPFHLKPAVQAKDRPGSPGLKHPDGSYLLFHPIYSEHELDSVKVVHRESKTFGDKVARAMCTAARTVFDMATRYPDHNGKKFPPLKRDVEKTVGLPSHLAKQVERLKEQTKDASVNAVAGSATAAAATTTSQSSTTSPTPTATKVVNQTGADLQELTSNDGAMTLQEMRAKGLSFGPDGWLNRMIFLESIAGVPGMVAATCRHLQSLRLMRRDKGWIHTMLEDAENERMHLLVALHLSGKPGLIARTFVLLAQGVFYNFFFIFYLLSPRVAHRFVGVLEEEAVLTYSLILEDLKEGRLPEWEDVPAPEIAKQYWQLGDEAMLVDVIRAIRADEATHRHINHTFASLNSDDPNPFALREPPAKMRAETYGLERDEALEWAKGKDLENGSDAATAAEKTA