lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the adenosylmethionine-dependent methylation of the exocyclic amino group (N(2)) of guanosine at position 10 of various tRNAs. Acts via a two-step process that leads to the formation of either N(2)-monomethyl (m(2)G) or N(2)-dimethylguanosine (m(2)(2)G).
Subcellular Localization:
Cytoplasm.
Sequence:
MKTTSYAVLKGNNYFLSLAELRALLNDDNAEINYFTGVAIFEGNKGDIANRSARIKRSGELVYISDDPKKINEMLRGGCFWIKEDVIMGSQKDKLNAINYEIKRGVKVSKECEKIDIILTDGVIILGKIKGQIDSKSLHEHEKKPFSQSGTMNPETSRLLVNLSRPKKEVLDPFVGTGSILIEARWLNYECIGSDLDKAMLQKTKINLNYFNYYCSLLFSSATNLPFRQITSIATDPPYGRSTKNKGAELTQLYEEFFSSASETLTKGGFLVFATDSRFNFIDKLKENSFIIKGLHYLYSHKSLTRAIYVVQKK
The following text describes a protein:
Function:
Possible component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit D may have a function related to the maturation of the monooxygenase complex, rather than direct involvement in catalysis. PaaD could assist either in maturation of PaaE or PaaA.
Miscellaneous:
MISCELLANEOUS: PaaD component is not essential for the reaction in vitro.
Sequence:
MQRLATIAPPQVHEIWALLSQIPDPEIPVLTITDLGMVRNVTQMGEGWVIGFTPTYSGCPATEHLIGAIREAMTTNGFTPVQVVLQLDPAWTTDWMTPDARERLREYGISPPAGHSCHAHLPPEVRCPRCASVHTTLISEFGSTACKALYRCDSCREPFDYFKCI
The following text describes a protein:
Function:
One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64f to detect sucrose, maltose, and glucose.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKGPNLNFRKTPSKDNGVKQVESLARPETPPPKFVEDSNLEFNVLASEKLPNYTNLDLFHRAVFPFMFLAQCVAIMPLVGIRESNPRRVRFAYKSIPMFVTLIFMIATSILFLSMFTHLLKIGITAKNFVGLVFFGCVLSAYVVFIRLAKKWPAVVRIWTRTEIPFTKPPYEIPKRNLSRRVQLAALAIIGLSLGEHALYQVSAILSYTRRIQMCANITTVPSFNNYMQTNYDYVFQLLPYSPIIAVLILLINGACTFVWNYMDLFIMMISKGLSYRFEQITTRIRKLEHEEVCESVFIQIREHYVKMCELLEFVDSAMSSLILLSCVNNLYFVCYQLLNVFNKLRWPINYIYFWYSLLYLIGRTAFVFLTAADINEESKRGLGVLRRVSSRSWCVEVERLIFQMTTQTVALSGKKFYFLTRRLLFGMAGTIVTYELVLLQFDEPNRRKGLQPLCA
The following text describes a protein:
Function:
Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. Required for cortical dynein-dynactin complex recruitment during metaphase. Plays a role in metaphase spindle orientation. Also plays an important role in asymmetric cell divisions. Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity).
Miscellaneous:
MISCELLANEOUS: Dysfunction of LGN is associated with the phenotype of multiple micronuclei due to chromosomal mis-segregation and defect in cell division through mis-localization of mitotic spindle regulator protein NUMA1.
Subcellular Localization:
Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton, spindle pole. Lateral cell membrane. Note=Localizes in the cytoplasm during interphase and at cell cortex during metaphase. Colocalizes with NUMA1 to mitotic spindle poles. Localized at the central and lateral cell cortex regions in a RanGTP-dependent manner. In horizontally retinal progenitor dividing cells, localized to the lateral cortical region. In vertically retinal progenitor dividing cells, localized at the polar cortical region (By similarity).
Sequence:
MEENLISMREDHSFHVRYRMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLGLSYSTNNSIMSENTEIDSSLNGVRPKLGRRHSMENMELMKLTPEKVQNWNSEILAKQKPLIAKPSAKLLFVNRLKGKKYKTNSSTKVLQDASNSIDHRIPNSQRKISADTIGDEGFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTSSTPPKMMLKTSSVPVVSPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTQNSQSVLSHLMTNDNKEADEDFFDILVKCQGSRLDDQRCAPPPATTKGPTVPDEDFFSLILRSQGKRMDEQRVLLQRDQNRDTDFGLKDFLQNNALLEFKNSGKKSADH
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MNKDTSSRSSQRSDRKLPARYRDDSIEVTTNVLQRTSTISQSGKSQGKEYASAHESINDISSSKNPENSHNSEVLSKRVLKVKCKTDVVRCDDVSVKRILSGNGAVKLQPKQNRKPKSKEEIGTTRDEDLSSKMDSKTTKKVLRCETCCRTFTRQSSLQRHVQAATCWKRLAAEADMGEENRDTGEQMLEGAHPRKGRIVCKICENSFVDKYTFLVHRRTHTGERPYHCTLCDKKFSQRSTLQFHVDTHSGQKHECSICGYKFTQARSLKRHMYFHTGNKEMKRNLVNRDFHKILVEVEKPERKEFELCDKEKVVMEMYECEFCKKYFKRVAELRVHLRVHTNERPFSCTTCGKSFKQLCHLNGHQKTHEKSETFSCADCGSQFTRAKSLQRHQAFKMCSGGKVLCRKRGRPQKIIIIDQEHDEGKMEATDEVNIHVDVTDGTTAHQVLENVYECANDIKSSEDRSESLGNGPIGNTDGQCEQELCGKALVGMNNFMPHKRTHGTKKAFTCNVCSKNFRLLNCLNEHLKTHSQDKPYSCENCNKRFKTLRCLLNHAGRNCCTGRRPFICDTCGKSYMYSRYLKTHRCHNTPVKVYSCSDCGRMYRRRDRLIEHMRIHTGERPFICNECDKTFAKIANFRLHQRVHTGEKKYECSHCRKRFAHNSTLRYHESTHKTEKAFPCDQCHRQFPRLKALQTHKQVAHNHGVTGNRYLCANCGKVYQHLKRLLKHHCEATSGKRFLCGVCFKHFDREKQLEIHMRVHTGEKPFKCEKCEKGFSQSGGLKDHMVCHNRVKKFQCDLCDVKFLRMKSLRKHKLIIHTGVEPQICKLCGATFKYYKALKKHEAVHETEQKTFTDILEDIEQAINSASTQVEKSNEAAVVQEVSEVDHMDQVAEVVIQDDGTCQEVIITDHPGDGHVFHLLQDPEQLEIDQSIHEIQIQAQLEEEEESTHQVLTSDVASVDHHEEVVSAP
The following text describes a protein:
Function:
Involved in drug metabolism, as part of an interspecies gut bacterial pathway for Levodopa (L-dopa) metabolism, acting on dopamine produced by Enterecoccus L-dopa decarboxylase. Removes the para hydroxyl group of dopamine to produce m-tyramine (3-tyramine). It is possible that dopamine dehydroxylation influences the multiple side effects of L-dopa administration linked to dopamine production in the treatment of Parkinson's disease.
Miscellaneous:
MISCELLANEOUS: Although all E.lenta strains examined are dopamine-inducible, less than 50% dehydroxylate dopamine. Intriguingly, this is due to the presence of a single-nucleotide polymorphism (SNP) that results in an Arg-506 to Ser substitution that inactivates the enzyme.
Sequence:
MGNLTMSRRTFVKTAAITGAAAAAFGASTHTALAEETYSSVSGNDTVAVKTCCRGCGKMECGVKVIVQNGRAIRVEGDEGAFQSMGNCCTKSQSSIQAAYHPDRLHYPMKRTNPKGEEPGWQRISWDEAMQSIVDNFMDIKAKHGGEAIACQVGTSRIWCMHSESILKNMLETPNNVEAWQICKGPRHFATTMVSQFAMSWMETITRPKVYVQWGGASELSNYDDSCRTTVDVASRADVHISVDPRMANMGKEADYWQHLRPGTDGALALAWTNVIIEKKLYDELYVKKWTNAPFLVCEDMEPSGFPTVRTDGSYWDVKTALLKESDIKEGGSPYKFLVYDNNWEKLKAEGVEHEYGAFTWFNADQEGVIDETGGFWEGENYDSEKARQGREAAQDNLLPGQTQGWLPDPMPFDPAIDPALEGEFEITLKDGKTVKVKPVWEHYKARAAEYKPEVAAEITGIPASEIEAAATAYGTRIDPSTGYGNGGIQYMLAVEHFCSAIQNCRAFDNLVGITGNMDTPGGNRGPTIVPIDGDLQGFSAWAPGATTPPEEVNRKQIGIDKFPLLGWWQYWCDSHSLWDAVITGDPYPVRALWNESGNFMSQTNTTRAWEALCSLDFYVDLNLWHTPQNDTADIILPVAHWIELNSPRASQGSAGAMGATVKCVQPPAEAKYDPEIVMDLARRMNWKWTDEPGNEWPDINWQLDDSIKLLTDDELTYTTWHVENGKPTFERHGVPMAEVTPKYKTWDEYVKAFQEHGWWQAKDIEPRNWGTYRRYQTGAMRARDRVWGRLDYTAGKGIGDWKPGWFTPTMKQEIWSTVMESHHPDHPEWRLPTYTEPPHGPKDGDRIKEYPLTATTGRRIPVYFHSEHRQLPWCRELWPVPRVEINPKTAAEYGIEQGDWVWIETEWGKIREVADLYYGVKEDVINLEHTWWYPEVKDAGHGWQFSQVNQLIDHYAQDPHSGTSNLRAYQVKIYKATPENSPFNNPVPCDSTGTPIIHTSDDPRLKEWLPTYEGRE
The following text describes a protein:
Function:
Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MAVPLALPSAAIIIVVLLLSSGLTTAEVEVAAVLEEAVLTLDVSNFSEVVGKLQFIVVEFYAPWCGHCKELAPEYEKAASMLRKHDPPVVLAKVDAYDEGNKELKDKYEVHGYPAIKIIRNGGSDVSGYAGARNADGIVEYLKKQVGPASIELRSALDATRSIGDKGVVLVGIFPEFAGVEYENFMAVADKMRSDYDFFHTSDASILPHGDQNVKGPLVRLFKPFDELFVDSQDFDKDAIKKFIEVSGFPTVVTFDDEPTNHKFLERYYSTPSAKAMLFLRFSDDRVEAFKSQMHEAARQLSGNNISFLIGDVSAAERAFQYFGLKESDIPLLLVIASTGKYLNPTMDPDQLIPWMKQYIYGNLTPYVKSEPIPKVNDQPVKVVVADNIDDIVFNSGKNVLLEFYAPWCGHCRKLAPILEEVAVSFRNDEDIVIAKMDGTANDVPTDFVVEGYPALYFYSSSGGEILSYKGARTAEEIISFIKKNRGPKAGALEEVTQTDAVQEEVTSTSSPSESVKDEL
The following text describes a protein:
Function:
Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MWLPLVLLLAVLLLAVLCKVYLGLFSGSSPNPFSEDVKRPPAPLVTDKEARKKVLKQAFSANRVPEKLDVVVIGSGFGGLAAAAILAKAGKRVLVLEQHTKAGGCCHTFGKNGLEFDTGIHYIGRMEEGSIGRFILDQITEGQLDWAPLSSPFDIMVLEGPNGRKEYPMYSGEKAYIQGLKEKFPQEEAIIDKYIKLVKVVSSGAPHAILLKFLPLPVVQLLDRCGLLTRFSPFLQASTQSLAEVLQQLGASSELQAVLSYIFPTYGVTPSHSAFSMHALLVNHYMKGGFYPRGGSSEIAFHTIPVIQRAGGAVLTKATVQSVLLDSAGKACGVSVKKGHELVNIHCPIVVSNAGLFNTYEHLLPGNARCLPGVKQQLGTVRPGLGMTSVFICLRGTKEDLHLPSTNYYVYYDTDMDQAMERYVSMPREEAAEHIPLLFFAFPSAKDPTWEDRFPGRSTMIILIPTAYEWFEEWQAELKGKRGSDYETFKNSFVEASMSVVLKLFPQLEGKVESVTAGSPLTNQFYLASPRGACYGADHDLGRLHPCVMASLRAQSPIPNLYLTGQDIFTCGLVGALQGALLCSSAILKRNLYSDLKNLDSRIRAQKKKN
The following text describes a protein:
Function:
Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif (By similarity).
Sequence:
MTTTLEEQLSDKLQMMDETTDKVQGSSKQKDDSSIAASSDAKTASPSSSDSSTKVAAPESEFYNKAQKYWSEVPATVNGMLGGLGYISAIDIQGSNVFLREIRVPGNRLALDCGAGIGRVTRNLLIPRFSCVDLVEQDPAFADKAREYCTSEDGSRGKVGQIYNVGLQKFTPTQQYDLVWTQWVLGHLTDRDLVSFFRRIKQGLAPGAFLCLKENVSSSKKTVEDRNDSSVTRPLDSYEHFLKEAGFRIVRKVKQQNFPKGLFPVYMIACKPVSKE
The following text describes a protein:
Function:
Converts protoheme IX and farnesyl diphosphate to heme O.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMYVTQLNRSHNQQVRPKPEPVASPFLEKTSSGQAKAEIYEMRPLSPPSLSLSRKPNEKELIELEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILARLSKIKLTALVVSTTAAGFALAPGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLLLMLTCKRPSGGGDAGPPPS
The following text describes a protein:
Function:
Required for the fusion of autophagosomes with the vacuole.
Subcellular Localization:
Vacuole membrane; Single-pass type I membrane protein.
Sequence:
MNLQFRLYLLFILLFISFANGKNEYEDKSTSIIDLLSSKSQFSKLIRRLQRNRLVPYLNRNKGLTLFAPLNEAFPDDSIEPNLLYYIVNTTELDRSVLRTQLKSSDGQQIALKIHYKAETGRAYDKVNNAQIVQSNWRADSGVVQVIDNIIDLPPPALEILSSEKDFSIFHRLSVAWVGEYSSVTMLVPDSSAFLNVYTNTELAYLYSMYAAEDVKTLIHQHILVNQRVYAEDVIEPKTFHYKNGISISMKFDKDQKKLFINDVSTTKYDLLTFSGAIHTVSSLINPEIISFTPAKYLIGIGAAWFSEKLSRERKSISVDKTSKRAILAPTNWAYREIIDIDYHIIENFDLPAPNKYALYVTNIKSGNSVGEDTNALVRIATGSAGEMYVNVETRSIQSENIGNVSLYVLDKDIEPPQPLLSQLILVDEISFSVRYLASLGLGDYTKVTWFLVKNSAWTQLGLVHLVLQQNLELLESVMLDYAFEGIAFYGSSDEAWASGNYTTLSNKEFLIEGVYEDSNSRNKRDLLRINNEIYEVQTRDLLVKDGVVHLVDKVKLPFSVSQKDMIIAGGRKEFLELLDKFEMLDMLDSGYPVVVPSLTGSDVNTKDSSFAERHIIDPEKRNFVISGSRLSVDSSPWISIQDYGYSELGNVYFVQNAIPTKRQNRWRITFISISGLLLSVGICVLCYKIYFKFFRNRFMNQGEREPLLAPADSDTMAGRRNSSSLSV
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MAHAVFTYDVGDLEHEEGFADEVEHTVIILGREFKFKYTDQGSRDEIRSRASAFLWFTYRNSEYAIGDSPRHKTDRGWGCTLRVGQMIVGEALQRCHCPRDYDKLSYPSEAARMSILKEFEDRPDRVLSVHAMAMQSKFVGKRAGQWHTPTDVAHVLRLAVNEQEAMGLQVHVAMDSMVVLDDLRKLFRADRATLLFVPLRLGIDIVQAEMIPAVKRFFHSPSALGIMGGRPGAAHYFIGYMDHNLLLLDPHTTQDPLRAGSQDALVSCRCSRPMLLDLDKVDPTMCLAFLLTDEESLQRFADDYNASVEETGVRLFSMLDTKSFASSVAVASSLAEEEEFSDDDFEVINMSAMS
The following text describes a protein:
Function:
Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
Sequence:
MEANGAGTPEERAGQLRWIADHLWSDTPHGAVHRAVEAQPQSVWLQLWHRAIADGARRPGPSCAVAAASEQEANWKGKESAIVVAAFVLSIPYRECPCAEEAGVVESGAKAAVRRYVCVSLGSGSRCLAAHDAPPSDAGAKMRRLLELRDGHAEVMARRGFIAFLLGIAEASARCSDRAYADLFLRRRSGDCDVATAVGASGSPQWELRETAAVHFVCTRWMCGSLAAVAGGSGRSGHLLLRAACGCWLDPTVQSEVSANEADCESCTVTHVDRHTLAAHYSPLNGAAPLLHAARVKPGKGRANLSMSCTDKVWRWYALGVQGRRRAPIFPVPMRLSSIHVLHPPFKELGDLQAAVDNAAVTFQWRSRRWWPHKDRDVSLPPTPKLAFFSSADFAATSPLVAAKLHDASVSIDSSYSRSRWLCVRSAVASRKRGRDEEAEVPALGSAMCSWQCFRSGGDHDCSLVLNTKAGLPRGMTGRALARRCSTSLEIPWQQCPLSRPWMHHRVRQLQASLTEIALISASVKANAAPASYATAAAGERDAQTIIADAEDLSMSQRVHHHHLQPLGTGEDSIRLLWASSSHMDGADLPLDATENFKGSP
The following text describes a protein:
Function:
May modulate chromatin structure by regulation of nucleosome assembly/disassembly. Could function together with B-type cyclins in the regulation of microtubule dynamics.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSNTKDNFNVADLAAALNADDSDDLVNVLKNKLQGLTGKHSNVLENLSPNVRKRVEVLREIQTQHDELEAKFFEERAALEAKYQKQYQPLYTKRSEIVNGVVEVDGEATQTAVADEEEDKDAVEKGVPDFWITAMKNNEVLAEEITERDEGALKFLKDIKWSRIENPKGFKLEFFFETNPYFTNTVLTKTYHMIDEDEPILEKAIGTEIEWYPGKCLTQKILKKKPKKGSKNTKPITKTEQCESFFNFFSPPQVPDDEEDIDEDAAEELQNLMEQDYDIGSTIRDKIIPHAVSWFTGEAAQDEDYIDLEDDEDEDDEDEDEEDEEEEDEDDDDEDEDEHVTKTKKKSSAGRKRSGGAPAADGQPGERPPECKQQ
The following text describes a protein:
Function:
Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase. Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop. May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAYTDPAQRNQVTVLQVGYSRQEEGDESAMRANCTCTLVRCRDGTNIIVDTLTAWDGDHLRSLLGQQGLGVDDIHVVVCSHGHSDHIGCNYLFQKARMHLVGACASHHDLYMDHLGSGNPDEQLALDSNAEVVVRRSPGHTLSCVSVLVENSQLGGRVGITGDLFERREDIDDENIWMDAGSENEKVQREERSKMAQLCEFIIPGHGPMFSVTQSMRCKLKEDATSNT
The following text describes a protein:
Function:
Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Involved in cell movement. Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (By similarity).
Subcellular Localization:
Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Sequence:
MGDWRTISLPESDKILQYSSEIRMSPTSLLSSPSHSAANTLSGIVYNFCTEDNIEQCITYIDQELRTIGFPTVQAVSKNGDGRKLHLVSIVNCIHELLQRNSQNMRSKEEVETQLLKINGDLEHLQSIYQRQKDQMEATRRENCALQERDRQMQCKNRNLLQLLKNEKEEVQKLQNIIASRSTQFNHSVKRKEREYNKLKERLYQLVMDKRDKKISIDVLNYVGRADGKRTSWRTGKTDAKNEEEMYKVLLNDYEQRQKQLMVENAELKKVLQQMKKEMISILSQRKTKEKLDDSIGPVASDIEEDLADSSKENLSELSCEAVREQLVSSIRQQWRILKSHMEKLDNQATPDENGMIARGDHEQELGKLINEIQQCKETIKIQQQLLKQQFSVPRDDTSTLLQDCYLLEDKERLQEEWKLFNEQKKNFEKERRNFTEAAIRLGHEKKAFEEDRAAWLKHQFLNMTVFTDHKNSEEKRAHGVHFSPEQDHCRLHSRTHDRHLASSGDHYQRPRKTLPITPSSKHSLTQRESVAWRDSSISPNGTDF
The following text describes a protein:
Function:
Forms fibrillar structures on the spore surface that contribute to spore wall integrity.
Subcellular Localization:
Spore coat. Cytoplasm.
Sequence:
MGLGNLCSYKQDDSLDILQKKVLIDAFNKVTIDGKPNVQHQQPTYWYPPPPPRHHKEHKKSHHHWEYSSDDDSSDDEESCEKKKPKCCEKKKPKCCESEQNNGCGRRNQLARRLAFLGSFGDGDCDGCNEAFTVTGPITYFRTCPDPLTGITPAVAAAAATPAAAATPATPAAAATPAAPAA
The following text describes a protein:
Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Subcellular Localization:
[Isoform 1]: Secreted; [Isoform 2]: Cell membrane; Single-pass membrane protein.
Sequence:
ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVNHKPSNTKVDKRVELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRFTQKSLSLSPELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA
The following text describes a protein:
Function:
Component of the nuclear pore complex.
Subcellular Localization:
Nucleus membrane; Single-pass type I membrane protein. Nucleus, nuclear pore complex. Cytoplasm. Note=During mitosis diffusively localized throughout the cytoplasm.
Sequence:
MDSILCMILLILVRNHASEAARLNHPRVLLPIFEDKAINFTLEVDEPNCYKWSSSRQDLISVMPIYKGFSECAYQAVVTVRTHDRRRNTAIVFAEEVQTGETLRSDVIVDVIASLNVRTATRQLYLEEAPAMFELHAFDEQGNEFFTLEGIEFDWEILEPGSKRPTAMRYLTFTDSPYHTVPPTIEKFEADGKKGHMILLEGINTGTAKVTIAMPQAEYKHVRPVEVYISVLANIIIEPSEVTIMAGDSVSFRILQLKMDRLHVIDNNQYYLEVEDSSIAYLRGNSATGAALGRTQVFLRDRNMADSDEVQKGPSALLTVAYPNRLSISLLPHLNWVTVQGEHHAIALDLFAADGQKITMGTKYSINSEVDESFFAIVDRTRNGSRLFGQAKKEGITQVYGSYKDLSVQAELQIFEELQLAPTKVVLPYDPNSLKPLKLQFHASGGDNNYAWFSGNPQVIQIDTQGQATTEIRDVKSAYVNQEVLKDGGKLTAHTTVKVALSKNQKISRVAHIYFLPPERLQITRSNFETALKDFVHVHVGVYARINNSEVPYTSCDNLHFQLDFSQPILQLEGNEGAEAAHEACHVLRLRATAVGTTSLRVSYMYMDKVLYDIIDLYVFEPLVVLNPIENEVVLPVGSSRNIIYANGPQRSFTVAAEIIQSTAFDEKILKVSKLEFDTQNLITAFTVLCRELGETQFTYRVHNSLPTSSFALYQSEVTTKVHCVRPRFLKLYARHNLRDSCPLEKRTSLLFLKDPENKIEIEIEVHDSNNRRLMNISSLGLDWEFSAGEERYQKNIIPHRQISELEFNHGVTLPSRDLLVLTLSEVATNFRIKGTVSQYNDKLLAQHGIHAERPPFGIKNPQTGLIYTPLIENEIRLHAVNSTLLPKDYMSIFLASGYSERIPIAQGSGYLQLELSEAGIVQVEYNENTRILVLTPLRLGHVRLELTDRCLMNEPSHLSISVVGIGAIEVVSMDRLERTTRIEAIVRLFDTNDNLLLVDQSKLSAYDLSEVVADQSILSVRLGEQENVGPGEIRYTITGNQVGETKILFQSGKGIYKVASDPLNIQVFAPIRLFPRDSTLVVGSSIQVYFHGGPHPNTNMIISVEKEQVATISSTVVTAHKLGTTKIVGKCLLKNPVTGKDEVVSQDSVEVHVVALKGVQIRTPLVRIHSGAVMPATLWGLSDLSPMILGTLQNTKISWKVSQPQVVEIFNVFTTAGIEYQSGDLISVRVRALNPGKATITASVTLADGTILPPATVDLQVFKTLELVTPNAIKMDSILAAPRSILQLKSNMDNVVYKLDDRSNGIVSVTPDGLVHTKDSLGRDLIIATTADQSLPIGIEVKNVQYILVTLMPILKLRELEHKIPRGMNFVFKVSLHDNLGNELSHNIEDFNGLRYELGNKDDVDVQIDNNLTFALNLMRETNNVIGISLKDSTGVKHSMDFIKLSVVESDNLFPTKTIFSVGDIICFDSPLTLSSTWRSSNEQIVYINKHTGIAQVLSHRLKPGEKIEITNGDETKRGGFLKYDLEVRESDTILFVKSVDTFSGPEYRGQLVIRNHLQSEKYSNLIAQNVSKCARELGSVPVNFFTCRLAAKDALGRNLLKMYKVDALFEPSIGQYSCRLQLLTGFIELLSIVKTHDVYLELEAVVAKGVSDKMSLKLVPGIKVFPESVRVTDLKPHEIHISGLDKALLKVQVKPSDSKYFAVDFIEHGHGLSKYRLELFDDLPLDENFYILVVSPDTKQSIEVPIIGNTMLAPKCTDRRYGGPLVYRILENLGFVLTTTVIVIISIWVYMSCFQTQGVTQVNFEAFKKGKSRTELMQQSGRSSQDDTFGDSFNVRNFSPDRRRPPSNALSESYIYGHPRLNSSNRSENSTSFS
The following text describes a protein:
Function:
Has phosphatase activity in vitro. Involved in the response to sodium and lithium ion stress (but not to potassium or sorbitol stress) by inducing transcription of the sodium pump ENA1/PMR2. Acts through a calcineurin-independent pathway and is functionally redundant with PSR2. Also involved in the general stress response; acts together with WHI2 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.
Miscellaneous:
MISCELLANEOUS: Present with 5620 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane.
Sequence:
MGFISSILCCSSETTQSNSNSAYRQQQSSSLNKNRSVKHSNTKSRTRGVHQTNSPPSKTNSAATFSSTERSTGKSGISTNDNEKKKPSSPTAAVTATTTNNMTKVEKRISKDDLYEEKYEVDEDEEIDDEDNRRSRGIVQEKGDAVKDTSRQKKQQQQQQQQSQPQPQPQSQSQSQSQSQSQQRGPTVQVSSDHLIQDMNLSRVSSSSQASETSNDADDEDDEDEEYIDLTLLQQGQYHAPGYNTLLPPQDESTKGKKCLILDLDETLVHSSFKYLRSADFVLSVEIDDQVHNVYVIKRPGVEEFLERVGKLFEVVVFTASVSRYGDPLLDILDTDKVIHHRLFREACYNYEGNYIKNLSQIGRPLSDIIILDNSPASYIFHPQHAIPISSWFSDTHDNELLDIIPLLEDLSVKTSLDVGKILDVTI
The following text describes a protein:
Function:
Probably has a role in the plant's defense system.
Sequence:
MAIVGGLVDVPFENKVEFDDLARFAVQDYNQKNDSSLEFKKVLNVKQQIVAGIMYYITFEATEGGNKKEYEAKILLRKWEDLKKVVGFKLVGDDSTMPGGIVNVPNPNNTKFQELARFAIQDYNKKQNAHLEFVENLNVKEQVVAGIMYYITLAATDDAGKKKIYKAKIWVKEWEDFKKVVEFKLVGDDIAKLGGITDVPFPNNPEFQDLARFAIQVYNKKENVHLEFVENLNVKQQVVAGMMYYITLAAIDAGKKKIYETKIWVKEWEDFKKVVEFKLVGDDSAKTGGIINVPNPNSPEFQDLARFAVQDYNNTQNAHLEFVENLNVKEQLVSGMMYYITLAATDAGNKKEYEAKIWVKEWEDFKKVIDFKLVGNDSAKKLGGFTEVPFPNSPEFQDLTRFAVHQYNKDQNAHLEFVENLNVKKQVVAGMLYYITFAATDGGKKKIYETKIWVKVWENFKKVVEFKLVGDDSAKLGGIINVPFPNNPEFQDLARFAVQDYNKKENAHLEFVENLNVKEQLVAGMLYYITLVAIDAGKKKIYEAKIWVKEWENFKKVIEFKLIGDDSAIIGGFTDVPFPNNPEFQDLARFAVQDYNKKENAHLEYVENLNVKEQLVAGMIYYITLVATDAGKKKIYEAKIWVKEWEDFKKVVEFKLVGDDSAKPGGIIIVPFPNSPEFQDLARFAVQDFNKKENGHLEFVENLNVKEQVVAGMMYYITLAATDARKKEIYETKILVKEWENFKEVQEFKLVGDATK
The following text describes a protein:
Function:
Catalyzes the phosphorylation of sphingoid bases to form sphingoid 1-phosphate (SPP), which have both intra- and extracellular functions (By similarity). C.elegans contain specific sphingoid bases, which are unique or different in structure compared to the sphingoid bases found in other animals. Two examples of these distinctive compounds are: 15-methylhexadecasphinganine and 15-methylhexadecasphing-4-enine. Required for neurotransmitter release from neuromuscular junctions. Acts by recruiting the synaptic vesicle priming protein unc-13 to synapses (Probable).
Subcellular Localization:
Presynaptic cell membrane. Cell projection, axon. Perikaryon. Mitochondrion membrane. Note=Recruitment to the presynaptic membrane may be regulated by endogenous acetylcholine, which activates a muscarinic signaling pathway acting through gar-3, egl-30 and unc-73. Muscarinic-mediated recruitment of sphk-1 to presynaptic terminals requires calcium influx and the calcium-binding protein calm-1. Primarily observed on the outer surface of mitochondria in body wall muscles.
Sequence:
MFIVVVTIFENYTQWYSSLLTIFSLTIKRKLKTIRSMQDSTSKCTCTEHHMGGTICCCCRSDAEENEQLTSVILSRKPPPQEQCRGNLLVFINPNSGTGKSLETFANTVGPKLDKSLIRYEVVVTTGPNHARNVLMTKADLGKFNGVLILSGDGLVFEALNGILCREDAFRIFPTLPIGIVPSGSGNGLLCSVLSKYGTKMNEKSVMERALEIATSPTAKAESVALYSVKTDNQSYASFLSIGWGLMADIDIDSEKWRKSLGHHRFTVMGFIRSCNLRSYKGRLTYRPYKPKGFHPSSNVFSVYEKTTQQRIDDSKVKTNGSVSDSEEETMETKFQNWTLPDSDETLAVGSSDLEETVVIEDNFVNIYAVTLSHIAADGPFAPSAKLEDNRIHLSYILWKDIGTRVNIAKYLLAIEHETHLDLPFVKHVEVSSMKLEVISEGSHVVLDGEVVDTKTIEVASTKNHISVFSSTA
The following text describes a protein:
Function:
Involved in calcium binding and microtubule stabilization.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLYKDLIGNSHDDLLTDRYEIKVGDVTFEVKTKMITKDLNVVVNNNSLGGSISTTVDNNNSITLSTNLEDEFENVEAAGTFQINNLVEQLRLVETSFDKKSYLAYMKLYIKDLINHIKQQPSNSDNEKIEHIQKGIQSFVKTMMDGENFKKYSFFTGSSMDANGLVALMYYKDDDPTTPTFVFIKYGLLQVDV