lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MNAKVVVVLVLVLTALCLSDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKRFKM
The following text describes a protein:
Function:
Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus. Melanosome.
Sequence:
MAAIAAVEARRRRSWTALVLACLGVCLGITFAVDRSNFKTCEESSFCKRQRSIRPGHSPYRALLDSLQLGPDALTVHLINEVTKVVLVLELQGLQKNMTRIRIDELEPRRPRYRVPDVLVADPPTAGLSVSGRDDNSVELTVAEGPYKIILTARPFRLDLLEDRSLLLSVNARGLLNLEHQRTPRVSQGSKEPAEGDGAQPEETPGDDNKPDETQGKPEHDEPGAWEETFKTHSDSKPYGPTSVSLDFSLPGMEHVYGIPEHADNLRLKVTEGGEPYRLYNLDVFQYELYNRMALYGSVPVLLAHSPLRDLGIFWLNAAETWVDISSNTAGKTLFGKMLDYLQGSGETPQTDVRWMSESGIIDVFLMLGPSVFDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNLPCDVIWLDIEHADGKRYFTWDPSRFPQPRNMLEHLASKRRKLVAIVDPHIKVDSGYRVHEELQNLGLYVKTRDGSDYEGWCWPGAAGYPDFTNPKMRAWWANMFHFDNYEGSAPNLYVWNDMNEPSVFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLVLRSGGIERPFVLSRAFFAGSQRFGAVWTGDNAAEWDHMKISIPMCLSLGLVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQYHEIIRDALGQRYSLLPFWYTLFYQSHREGIPVMRPLWVHYPKDVTTFSIDDQFLLGDALLVHPVSDSEARGVQVYLPGQGEVWYDVQSYQKYHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSDCMKDDPITLFVALSLQGTAQGELFLDDGHTFNYQTRHEFLLRRFSFSGNTLVSSSADPKGHFETPIWIERVVIIGAGKPATVVLQTKGSPESRLSFQHDPETSVLILRKPGVNVASDWTIHLR
The following text describes a protein:
Function:
Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association to the ESCRT-0 complex.
Subcellular Localization:
Endosome.
Sequence:
MMEVKLWNDKRERERYDNFGELFAIIKATEKLEKAYVRDIVSPAVYETECLKLIAQFKTLSSTLKDAVPNIERFHDTYKMDCLAALNRLVTSGVPATVEHRAAASMSAVTSAAVVAECVQNFITAMDSLKLNMVAIDQVHPLLSELSSSLNKLSILPVDFEGKTKMREWLSRLSKMGAADELTEQQARQLHFDLESSYNSFMAALPTAGT
The following text describes a protein:
Function:
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Involved in chromosome segregation. May contribute to chromosome decatenation.
Subcellular Localization:
Cytoplasm.
Sequence:
MKHPLEELKDPTENLLLWIGRFLRYKCTSLSNSQVKDQNKVFECLNELNQACSSSQLEKVCKKARNAGLLGINTYALPLLKFHEYFSKARLITERLAFNSLKNIDEVMLAEFLSVYTGGLSLATKKNYRIALLGLFSYIDKQNQDENEKSYIYNITLKNISGVNQSAGNKLPTHLNNEELEKFLESIDKIEMSAKVRARNRLLIKIIVFTGMRSNEALQLKIKDFTLENGCYTILIKGKGDKYRAVMLKAFHIESLLKEWLIERELYPVKNDLLFCNQKGSALTQAYLYKQVERIINFAGLRREKNGAHMLRHSFATLLYQKRHDLILVQEALGHASLNTSRIYTHFDKQRLEEAASIWEEN
The following text describes a protein:
Function:
Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility.
Subcellular Localization:
Cytoplasm.
Sequence:
MMQATAVVETASGKGYHSNGGNLQKDKPSNPKEENLLLSSNGCDEVKLTFPDDDWDSSTLEQRANNKEISNIDKMDLLEPFFSVSQDTNTESTQFQSSELEDSTDYAFLNKTYSIPYSESKLKKESLTPLSSELDPEVQKKEEVFFYILEHQDKTVGLERLYNISDANYRESAEDTQKHDTDEDSQQEYHSAEEQEYISNHLSFDQTKTLGISNPEVVELGNSGYEVKCASNVEDNRVNSGSGSIISLDSLDVYGQEESLHVSKFRNSVMLREYHDLKHEKYKEQETSSMYHTVFDGSVLRSNSPGNQESQSKSGSLSPQKVLKMKIYTENMKSQINEGKDFCGNKIVENKILLHLENPSTLPQDKALETLPQPCKDCQTSWTSVFDDSIISACGYYESLQNTADSSLDFSAMLPKIAVRDNQAIEDNTSLKVAHSSTTKKTCFHNIGETCTKSLTDAASCTVTINQTVDVSTDFRACFTTSRATSARPSVVSTSSNTEITMMNKKRPDEWQNEKQKSVACSTDWSYSEDCIDTQMAITKGSGKSPSVDSLKPNGNFLNKDFLELRKACGITDLKKHPEREFQLFKDTEKDLPSMCCQKIMQRAIKAELHLLNVHYQMCRRHFCDIYKLVMENREGLNMNLSSNSAKKELGSALLSLLGDLKVRYVTLKEKIHKGIPLEELPPLSLESKLLSTFSTFASRLMKKETHVFSEADAEQDDQRAHDVDVSSNLKKTLSQMCLSSDNSHATQNVSPKKDDFKNGDINGDFSQLKLDDKDCRHYQEISEDWSDAKENLTGVDISGTQENQIEQDRWNLDLTVEMKNVEPSQRDKGYLIHVGGLCPSVSEADLRSHFQKYQVSEISIYDSTNYRYASLAFTKNSDAKIAVKEMNGIEINGKSVNVWPVKILGEYTSPLSSKNGNRISSNNLEKSTNKQIHSEFSISRLPRTRPRQLGSEQDSEVFPSDQGVKKNCKQTESAKLLPDTPVQFIPPNTLNLRSFTKIIKRLAELHPEVSRDHIINALQEVRIRHKGFLNGLSITTIVEMTSSLLKNSASS
The following text describes a protein:
Function:
Probable transcription factor. Required for female gametophyte development.
Miscellaneous:
MISCELLANEOUS: Assigned as a member of the MYB-related gene family, I-box-binding-like subfamily.
Subcellular Localization:
Nucleus.
Sequence:
MASGSMSSYGSGSWTVKQNKAFERALAVYDQDTPDRWHNVARAVGGKTPEEAKRQYDLLVRDIESIENGHVPFPDYKTTTGNSNRGRLRDEEKRMRSMKLQ
The following text describes a protein:
Function:
Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages.
Subcellular Localization:
Secreted.
Sequence:
MALEGRTMSLFLSLTLLLLSVVATSYSETVTCEDSQKICPAVIACNSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGSSGSPGPKGQKGDPGESPDCESSLAASERKALQTEMARIKKWLTFSLGRQVGNKFFLTNGEMMTFDKVKALCAEFQASVATPRNAAENRAIQNLIKEEAFLGITDENTEGEFVDLTGNKLTYTNWNDGEPNNAGSNEDCVLLLKNGKWNDIPCSSSHLALCEFPI
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MPKYQPKNGELNPYIPRYILETPRYQQDIINKSPEQEDAQDQTTTAHDPLAHQRKTGEIIDNSIAQSGTGIKDEFKGTIRVEENESYDSKRDRWYGYSTEEWLTHLKNWNDKKQSRKHASAQDNDDSDDTDYELELIELELDKKDMKKNIKKDPMEKMLRDRQDIPAYIYNITSNPNNKIRIEYDPKSRLAKDSAKGFLNKRNQFVKKLTGDGDELMKLQKMAQELDNEHEKDRKLAKLKQEFYGEENPKTVPQTDLSLSLEASPTLMMLKSKQLQNEKLAKSIQSKQEVMEKYNASTESDEKESKKTGHLEDKLFLNHKYIYGSYYENGKWGYKCCKQFDKNSRCTATD
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MLKSSKYFRSSLGERNFWGFTKCFIEEKREDEAADWWPSWTSLRPLDVSPVRRTSLLYIFAVVRISLGQSTGQRRDIDGRKGGGLRHSLRSIKRKKWVGAWVQGYVDEQFIELEELQDDATPNFVEEVVSLFYEDSARLIHAIDQSLENHPIDFAKLDNYMYQFKGSSSSIGAKKVKTECTQFMEYCRARNVEG
The following text describes a protein:
Function:
Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRKIAPNYKSMDQALGDLVARFAPEYAACRRVLQEAVGLLGSRSAVAADTGSGDGGGTWPPREVLIHGAGSGAAVIAALETLPLGSLESAVAVEESIMRQTLGARLERRYRAAVSGGSDGGGAGLAAAAVHASFGPWNPRHRGGSSAAVELDSAERVKGGARAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAAGAAEGAAAAGGGGSWPRVSWVRGLAPVHKSPGSQRRRYDLVIAPYQLVLLPTLEDKMTLVRQLWERCGGSLVLVEPGTPAGFGDLAEARELLLALEARRGQQLQAALERGDARAAAKLAGSGAHVVAPCPHDGACPLWKVGRSTWCSFEQTLLRPDFMRNTAERRLPGAPLPRRYGAKDKQDECFTYLVIRRGPRPQRRVAVARAYAPAAPPAQPLAGPGTGSGESAEPAAAAAAAAAAGLRVPQRAVLMQVLIDRMAATEPEADTSGNAALPKGGGSSSDGEGAGDRGEQRARTPLFGHSAGAAASVNAAGSSAAGAAAAADAALAAAGPLPGVGGSSSPAVAAFTRKYPAYGPGLVGRLLALQEAGVDWATASQEASNTAAEAPEQEQVGGVTGVVAGSNSSKPAGSVASQHRPGLDAALAQMAMSLVPSGSTALSAPAAEALRAALLQAGQPGADAADEGLGAEQGGSEGLGAEQGGSEGRLSRLSRQDVSDEEYAAAEAQLLRRVYLGGGSASRAADGAAGAGGASPAWDGDSGAPAGSDSESDSDDESSAAGAAGGRDPRAVVVAPPAEVHLALASSYGWGRVLRPPRRRGKHVVVDMCMGPQQQYLFADQPAGSGVAAAGAVAAEQAAGTGKGEGQGLEAAGGADDGQRSGGAATDGGRGKHAEQDEAESTAGRTVQQVVPRSARNSWMGVPAYRLARHLGWGDVWPDWFARSHTVKEVGPVPRRQQQQRQRPGEERAAGHGEGEGQGEGVSEVEVKEHGSTYQGTGGVRSDGYN
The following text describes a protein:
Function:
Implicated in the pheromone A- and alpha-factor response pathway. The beta and gamma chains of the putative yeast mating response pathway G protein play a positive role in initiation of the mating response.
Miscellaneous:
MISCELLANEOUS: Present with 5550 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Lipid-anchor.
Sequence:
MTSVQNSPRLQQPQEQQQQQQQLSLKIKQLKLKRINELNNKLRKELSRERITASNACLTIINYTSNTKDYTLPELWGYPVAGSNHFIEGLKNAQKNSQMSNSNSVCCTLM
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSNAETVLDTEITKSVDNSLTRKLKDIAAGFVGGATQVLIGQPADLVKIRLQTTSATSSFQVIKNVIKNEGILAFYKGTLPPLFGVGVCVSLQFYGFHETKRQILQYTGQPSLNLWPQTYIAGAMAGVVNTPVTAPVEQLRILSQSSGKPVSLRETVSKIYREQGIVNGIYRGFGITLIREIQAYGVWFLTYETLIQKIIDLQHYKSRDQISTPELLASGAIAGNALWLSSYPLDVIKSNVQSDGFGKDSKFGGSSLKALRYIYSHHGLTGFWKGIVPCLLRAVPCSAGTFASVELALRLMG
The following text describes a protein:
Function:
Required for the processing of the 27S pre-rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDVAAEHRTQHNDTEGLRRRLSDIFDGVNWLERIDVTLSYCLAQDLLHATKEVAVDKTFSDDNVARIHDDFQREASLQAQKAVIEALPKLHSENVITKRPADYFAEMVKSDIHMQKIRRKLLEKQENIKSFEKAKRIQFIKKFGKKVEKEVISNRKNLQSGKSNGKLNKGANLVEMKTQKSVDNYVNKSRSPRLSNKGRKDMKYGYGRKKKNIKKNTSASANTSFFDSGIHGKPRKKRSSAGNKRPGKRRRLQKR
The following text describes a protein:
Function:
Flagellar protein involved in sperm flagellum axoneme organization and function.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MKEPDDQDTSDGGRSGSRNEGKLAHKSILKSSQDTTADSYTDGEESYLGDDLDLDDMDESSHSSQEYVQAPAPSQEPPVEVKEEPEADVKKVLSETFYYDYPELVSIPYVSSEERIPLYFLTLNHSFGYDCRKRANLQLLDSNTLLYVAGNQMVLLDFKDKTQIYLQSSSGQGIGAIGVHPKKTYFAVAEKGSFPKIIIYEYPSLKPYRILRDGAEKAYAYVDFNNEGNLLASVGCHPDYTITIWGWKEEQPILRTKAFSQDVFKVTFNPDNDEQLTTSGSGHIKFWEMAFTFTGLKLQGSLGRFGKTSTSDIEGYAELPDGKVLSGSEWGNLLLWEGSLIKVELCRTGMKSCHSGSINQIMLDEGEVITAGSDGSVRIWDFETIDTADVIDDTGLLEIEPINELHIDKSVNLFSMIKMNEVGNNFWLAQDANGAIWKLDLSFSNITQDPECLFSFHSGPIAALAVSPLTYLMATTAMDCSVRVYDFSSKNPLVHMKFKQGGTSLIWAPRSVSVSASQIVVGFQDGVVRVLELFDPKGLTVYAGRKKIPDAELHLKYVFKPHTDEVTALAYERDGDILATGSEDKTVFFFDVEKEYKPIGFFNTPGPICQLMWSPASHPEKTLLIICENGYILESLCPTIKDVDDQNVITFAIPNVFLRCFHFTSVKSKILRFLEVQRREQQKMLKEKEKLERRMKLAEEREAFGEEEIPEEETSEEGEEEEPPLPEIFMPPTPSPILCGFYSEPGKFWVSLGNYDAGFLYHCQFPSYLHNSDFQKQENEPFDFRVLENTEDNPIRNITFSNDQTMMFCGMTNGAIRVYVLSENDPFLVSLQHYWHFNVHDNNYGSIKSITSSFDDQYLLTAGEDGNIFVFDIFSEFIVPKGIKAKVPSPRFGIESEAAPEDIEDPKAYSIENARKKREHDKLMKKVEELKAHKREQIKILRNEFWKLLELNKELPAHMQFQRTDFNIDAKIHAEIHKKTSLKIEQVEKELAWEKQKHELGLKKLQDRFREPLESDTIVVYATQSDHQIASYRLVKPSKYSKLKRPSQSERRQSKMERLEKEGPGKKESQRDTGGSISLQEESVLEKGKKFRPRTLSEIMVENQIEKTKKLIQQAERAQFKILQRKKEWEELYKSKPDDDYEDPKDVQAIKEAQTYMGDFNLKTAPDYKIPEHMRINAAKKEEELGYLDTMAHGKKRYMNKCILSLRDLKLAVIEEIQCLVQELKNIQSSIPASKHMPIPQVPQIYPEEVPERRFQYDEETLLRFQRKQKKRQDKSSSKQSGTGSGGSAGGGLVGFLKLSSGKEGDLTTRDSLSRSSKASALLELPKPVEFEKAEPSDAELEIMKRDEVKHLYMQQFLCNRINELTVTFDAELHLLRHQKLKLDTKMKLSDLHHLTLFQEMLLLKNFEKQENILQERVNSLDKEEQDMQWKINETLKEMEEKKNEITKLQDQEKALYAGFQAALGENNKFANFLMKVLKKKIKRAKKKEVEGDADEDEESEESSEEESSLESDEDASGSEDDVFDDSICPTNCDVSLFELALQLREKRLDIEEALVEEKKIVDNLKKEYDTISKKVKVVATNLNAAEEALEAYQREKQQRLNELLVVIPLKLHQIEYMEFGEVPEDLSGTLVFSNHSLDRLQERIVQLQEENAKQQKLNKECRERRKLLIREKREMAKTISKMEETVRELMISKFGRVIDLEALQTLSVNTTLEELKIKKLRKELSNAKELRMWEEKIAQVRWDLMMKTKEHTKKLHQMNDLCLEKKKLDSRLNTLQNQQGNAFQGLRKADIVAKQKVTELVQTQLEKITALKEEIELLRKKGGLLLPPITPKPKNEMKPMDT
The following text describes a protein:
Function:
Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
Miscellaneous:
MISCELLANEOUS: Antibodies against HcpB are present in sera from human patients infected by Helicobacter pylori.
Sequence:
MVGGGTVKKDLKKAIQYYVKACELNEMFGCLSLVSNSQINKQKLFQYLSKACELNSGNGCRFLGDFYENGKYVKKDLRKAAQYYSKACGLNDQDGCLILGYKQYAGKGVVKNEKQAVKTFEKACRLGSEDACGILNNY
The following text describes a protein:
Function:
Hydrolyzes laminarin majorily to glucose (G1), laminaribiose (L2), laminaritriose (L3), laminaritetraose (L4) and laminaripentaose (L5). Hydrolyzes laminarioligosaccharides L3, L4, L5 and laminarihexaose (L6) to G1, L2 and L3. Hardly hydrolyzes L2. Does not hydrolyze lichenan, pustulan, carboxymethyl cellulose, locust bean gum or soluble starch.
Subcellular Localization:
Secreted.
Sequence:
MNAFTFPLLLAFCAFAHGAWVLDWEDEFNGGNLADRWNFELGCNGWGNNELQCYTDNRGANARQEDGKLVISAVREWWGDGVNPDKEFTSARMTTKANWLHGKFEMRARLPKGKHLWPAFWMMPQNSEYGGWPRSGEIDITEYRGQRPQQILGTLHFGAAPDNKGDVGTGERDFPIDFSADFHTFGLDWSPDSMQWLLDDQVYHTESLQRNFWDGVYNQNGSPFDKNFFIILNLAVGGNFFGGEPFDPSESDGWAKNTFEVEYVKKWTWN
The following text describes a protein:
Function:
Nonribosomal peptide synthase which is required for the regulation of histamine and dopamine levels in various tissues through their condensation with beta-alanine. In epithelial glial cells, plays an essential role in the inactivation of histamine, the main neurotransmitter in the optical nerve system, by catalyzing the conversion of histamine into carcinine. In the cuticle, catalyzes the condensation of beta-alanine with dopamine to form beta-alanyl-dopamine (NBAD), a metabolite involved in the pigmentation and sclerotization of the insect cuticle. Also, regulates the cuticular hydrocarbon composition in females. Acts downstream of the body clock to regulate circadian behavioral rhythms. Can also condense beta-alanine with biogenic amines tyramine, octopamine, and serotonin in vitro.
Subcellular Localization:
Cytoplasm. Note=In glial cells, localizes to thin sheets of cytoplasm enwrapping the cartridge elements of photoreceptor R1-R6 terminals, extending between their profiles, but not into their capitate projections.
Domain:
The nonribosomal peptide synthase is composed of three domains. The adenylation (A) domain is responsible for the adenylation and activation of beta-alanine using ATP. The thiolation (T) or peptidyl carrier protein domain (PCP) contains the prosthetic group 4'-phosphopantetheine, which activated beta-alanyl-AMP is transferred to via thiolation. The condensation (C) domain both performs the selection of the amine substrate, dopamine or histamine, and the condensation of these amines with beta-alanine via an amide bond.
Sequence:
MGSLPQLSIVKGLQQDFVPRALHRIFEEQQLRHADKVALIYQPSTTGQGMAPSQSSYRQMNERANRAARLLVAETHGRFLQPNSDGDFIVAVCMQPSEGLVTTLLAIWKAGGAYLPIDPSFPANRIHHILLEAKPTLVIRDDDIDAGRFQGTPTLSTTELYAKSLQLAGSNLLSEEMLRGGNDHIAIVLYTSGSTGVPKGVRLPHESILNRLQWQWATFPYTANEAVSVFKTALTFVDSIAELWGPLMCGLAILVVPKAVTKDPQRLVALLERYKIRRLVLVPTLLRSLLMYLKMEGGGAAQKLLYNLQIWVCSGEPLSVSLASSFFDYFDEGVHRLYNFYGSTEVLGDVTYFACESKKQLSLYDNVPIGIPLSNTVVYLLDADYRPVKNGEIGEIFASGLNLAAGYVNGRDPERFLENPLAVEKKYARLYRTGDYGSLKNGSIMYEGRTDSQVKIRGHRVDLSEVEKNVAELPLVDKAIVLCYHAGQVDQAILAFVKLRDDAPMVTEMQMEARLKDKLADYMTPQVVILEHVPLLVNGKVDRQALLKTYETANNNEGDSSIVLDFDYSQVPEDLKLTARDLFETVGGVIGRSTRATLAPHSNFYELGGNSLNSIFTVTLLREKGYNIGISEFIAAKNLGEIIEKMAANHDAVQLEEESLNACPHLKMEAVPLRLEHRQEVIDIIVASFYNKADLEQWLKPGVLRTDYSDILNDIWNVLVERDLSFVVYDTNTDRIIGTALNFDARNEPEVDIKSKLLIVFEFLEFCEGPIRDNYLPKGLNQILHSFMMGTAEKLNPRENIACMHFMEHEVLRVAREKQFAGIFTTNTSPLTQQLADVYHYKTLLNFQVNEYVHSDGSRPFGDAPDEQRAIVHWKEVGK
The following text describes a protein:
Function:
Ribosome biogenesis factor required for cleavage of pre-rRNA at A0, A1 and A2 sites. Essential for the incorporation of UTP25 in pre-ribosomes.
Miscellaneous:
MISCELLANEOUS: Present with 1460 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSRAKELQEKLNLQAKLQSTFSNNTAAVLDWLKESDETGISNDTERNKQLKDHKELEDGKKAFFKLPVLQIGSGLHFRTQDDASAKEDIHTIGEFIEGDKKVSSLAKKKKRSDPGLQRNNMYRITKDDTKAMIALKRKMRKGEKEGLRKKQEHSKSSVSNSYSASDEEDEDAGTMPQKSTKKKFGLLFDKKKKARK
The following text describes a protein:
Function:
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MAPEAAQMEVERRLRDIGARFSSLPEPNTELLSLLEEADTWLSRVDQSPPTSISNALRPTMEALTKKGLLNHPDPGVKVAVASCLTEVTRITAPEAPYEDDVMRDVFTAIVVEAFGNLDDMDSPSFAKRVSILETVAKVRSCVLMLDLECEDLIRDTFHHFFRTISSTHQENVSSSMETIMMYVIQESEAVHPDLASCLLQNLRKEKKDSFPASLTLAEKIVNLCPEKLKPVFIQLLQGTPLNLYSETVESLVEGSSHARDDKDDASGKDTVADKKLPQTTVSDKSPQEISKSEKDVNCPGQDESHPCSTLTPSLNNGGASADNVKAPNGPASSKQKPELLSDDKQTKVSDELIHSDKEAPEPVTAEPGKLSGISSKKSRKLDTSTEYEVTERSKVPSVNQGLVASGELSPETNDGKNELALETGNRAADDKSKPVDSTPAVDKPKRGRPPAAKSQEKKPVGKSQVSGLESKEVRSRSASGGRAKDGVKLSSRRSNVEESSKNQPKDRSNLQKEDTLSDEETDEDQSLKEMVSPKSFTKMEKSKAQPGDSGGSKRKRSQEAEEVPPSKKNKVLDGSLIGSRIKVWWPDDKKFYNGVVKKFDANSKKHKVVYDDGDIEILLLKDEKWEFITHSKQDSIDDSDLPKKRGRPKVLRSTNSMSNDDSPVTSARLKVKSAEKDAGETPKAGSSLRNEGGRLSRSSSKVSNKDEAVSTKSVNRSKDVAVSKHKESSVSNPKGPSTQKASDGSKSNGLSTKRRPREKEVSSEDEEQGSAKASIGNKRRRKVLN
The following text describes a protein:
Function:
Component of the peroxisomal translocation machinery with PEX13 and PEX14. Interacts indirectly with the PTS1 receptor (PAS10/PEX5) and directly binds to PEX14. Required for import of both PTS1 and PTS2 proteins.
Miscellaneous:
MISCELLANEOUS: Present with 656 molecules/cell in log phase SD medium.
Subcellular Localization:
Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTSINSFPRNIDWPSNIGIKKIEGTNPTVNAIKGLLYNGGSIYAFLYFVIAMFVEPTLQKQYQQRNDFSLFVLLRLRRIIAQLQKRLVMTPVSSLGFNEQNNFVERSTQTSDDNIIREDNSHWAEMIYQLQNMKQELQYFNRSSGQPSESIDDFVFQIKMVTDQVELTDRSRAFSNKSRNIIQGIREIKGWFVNGQVPR
The following text describes a protein:
Function:
Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'-phosphopantetheine (Ppant) moiety from coenzyme A to the apo-domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-forms which make them competent for the activation of 2,3-dihydroxybenzoate (DHB) and L-serine, respectively.
Sequence:
MRAMNDRLPSFCTPLDDRWPLPVALPGVQLRSTRFDPALLQPGDFALAGIQPPANILRAVAKRQAEFLAGRLCARAALFALDGRAQTPAVGEDRAPVWPAAISGSITHGDRWAAALVAARGDWRGLGLDVETLLEAERARYLHGEILTEGERLRFADDLERRTGLLVTLAFSLKESLFKALYPLVGKRFYFEHAELLEWRADGQARLRLLTDLSPEWRHGSELDAQFAVLDGRLLSLVAVGA
The following text describes a protein:
Function:
Required for localization and recycling of the CPY sorting receptor (VPS10) to the late-Golgi compartment. Involved in the retention of proteins to the late-Golgi. Plays an integral role in the complex vacuolar protein sorting process.
Miscellaneous:
MISCELLANEOUS: Present with 736 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus, Golgi stack. Note=Associated with the late-Golgi membranes.
Sequence:
MEQNGLDHDSRSSIDTTINDTQKTFLEFRSYTQLSEKLASSSSYTAPPLNEDGPKGVASAVSQGSESVVSWTTLTHVYSILGAYGGPTCLYPTATYFLMGTSKGCVLIFNYNEHLQTILVPTLSEDPSIHSIRSPVKSIVICSDGTHVAASYETGNICIWNLNVGYRVKPTSEPTNGMTPTPALPAVLHIDDHVNKEITGLDFFGARHTALIVSDRTGKVSLYNGYRRGFWQLVYNSKKILDVNSSKEKLIRSKLSPLISREKISTNLLSVLTTTHFALILLSPHVSLMFQETVEPSVQNSLVVNSSISWTQNCSRVAYSVNNKISVISISSSDFNVQSASHSPEFAESILSIQWIDQLLLGVLTISHQFLVLHPQHDFKILLRLDFLIHDLMIPPNKYFVISRRSFYLLTNYSFKIGKFVSWSDITLRHILKGDYLGALEFIESLLQPYCPLANLLKLDNNTEERTKQLMEPFYNLSLAALRFLIKKDNADYNRVYQLLMVVVRVLQQSSKKLDSIPSLDVFLEQGLEFFELKDNAVYFEVVANIVAQGSVTSISPVLFRSIIDYYAKEENLKVIEDLIIMLNPTTLDVDLAVKLCQKYNLFDLLIYIWNKIFDDYQTPVVDLIYRISNQSEKCVIFNGPQVPPETTIFDYVTYILTGRQYPQNLSISPSDKCSKIQRELSAFIFSGFSIKWPSNSNHKLYICENPEEEPAFPYFHLLLKSNPSRFLAMLNEVFEASLFNDDNDMVASVGEAELVSRQYVIDLLLDAMKDTGNSDNIRVLVAIFIATSISKYPQFIKVSNQALDCVVNTICSSRVQGIYEISQIALESLLPYYHSRTTENFILELKEKNFNKVLFHIYKSENKYASALSLILETKDIEKEYNTDIVSITDYILKKCPPGSLECGKVTEVIETNFDLLLSRIGIEKCVTIFSDFDYNLHQEILEVKNEETQQKYLDKLFSTPNINNKVDKRLRNLHIELNCKYKSKREMILWLNGTVLSNAESLQILDLLNQDSNFEAAAIIHERLESFNLAVRDLLSFIEQCLNEGKTNISTLLESLRRAFDDCNSAGTEKKSCWILLITFLITLYGKYPSHDERKDLCNKLLQEAFLGLVRSKSSSQKDSGGEFWEIMSSVLEHQDVILMKVQDLKQLLLNVFNTYKLERSLSELIQKIIEDSSQDLVQQYRKFLSEGWSIHTDDCEICGKKIWGAGLDPLLFLAWENVQRHQDMISVDLKTPLVIFKCHHGFHQTCLENLAQKPDEYSCLICQTESNPKIV
The following text describes a protein:
Function:
May play a role in abscisic acid (ABA) signaling.
Sequence:
MGERFFRNEMPEFVPEDLSGEEETVTECKDSLTKLLSLPYKSFSEKLHRYALSIKDKVVWETWERSGKRVRDYNLYTGVLGTAYLLFKSYQVTRNEDDLKLCLENVEACDVASRDSERVTFICGYAGVCALGAVAAKCLGDDQLYDRYLARFRGIRLPSDLPYELLYGRAGYLWACLFLNKHIGQESISSERMRSVVEEIFRAGRQLGNKGTCPLMYEWHGKRYWGAAHGLAGIMNVLMHTELEPDEIKDVKGTLSYMIQNRFPSGNYLSSEGSKSDRLVHWCHGAPGVALTLVKAAQVYNTKEFVEAAMEAGEVVWSRGLLKRVGICHGISGNTYVFLSLYRLTRNPKYLYRAKAFASFLLDKSEKLISEGQMHGGDRPFSLFEGIGGMAYMLLDMNDPTQALFPGYEL
The following text describes a protein:
Function:
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
Subcellular Localization:
Secreted.
Sequence:
MGLTSQLLPPLFFLLACAGNFAHGHNCHIALREIIETLNSLTEQKTLCTKLTITDILAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLEDFLERLKTIMREKYSKCSS
The following text describes a protein:
Function:
Uniporter that mediates the transport of neutral amino acids like L-tryptophan, proline and alanine. The transport activity is sodium ions-independent, electroneutral and therefore functions via facilitated diffusion.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein.
Sequence:
MDATELGVSGEGEEIDMEVMRPLIESEDRFEGTYGEKKHLQRYLNSDNKKDEEVMKPLIENEDDSDGTCDEHQYLQRHPDLDNKDGLTFFQTLIHLLKGNIGTGLLGLPLAMKNAGVLLGPISLLFFGIISIHCMNILVRCSHFLCQRYKKANLGYSDTVGLALEVGPGVLQRHASFGRNLVDWFLVVTQLGFCSVYFVFLAENIKQVFEVFLETKLQQSEIGIWSLDLRIYMFSFLPLIIPLVFIRDLKNLSLLSFFANVSMAISLLIVYQYVIRNLSDPRTLPLGTSWKTYPLFFGTAIFAFEGIGVVLPLENRMRDKKDFSKALNIGMAIVTTLYISLATLGYFCFGDQIKGSITLNLPQDSWLYQLVKILYSFGIYVTYAIQYYVPAEIILPAVTSRVQKTRKLLCEFTMRFFLVCLTCAVAVLIPRLDLVISFVGAVSSSTLALILPPLVEIITYHKENLSPWVIMKDVGIAVIGFVGFIAGTYVTIEEMIYPISYVPPNVSHSDFGVLNNTVLEGH