lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MEKDEMTQEMEHYQRIVRAFLYYRIHSLKRVNQARRCFTSLSKEDQQLAPKFTTKLDLIKMAIGVNYDFIRTILQRTQNLFLNSEIYQMDEVISSVYIKLTYLISTVPEFDMEKVKSTIKQFVRDWSKEGEKERNTCYLPIINEILRLFPRDDIQPNAINILVPGAGLGRLAFEIVKLGYNCQGNEISLYMLITSNFILNNCTTTEQYVIYPWVHQYCNIAGFDDQVRNIKIPDMAPSEIPKDTSFSMCAGDFLLVYNDPGKKWDCVATCFFIDTAHSIIAYIKKIYQILKPGGYWINLGPLLYHFADMAGEQSLELSYEEVKTVIENVGFSYEKEEKGIVSGYTQDPSSLMTTLYHNIFFIVRKPEIDQQQ
The following text describes a protein:
Function:
Probable transcription factor required for peripheral nervous system morphogenesis, eye development and oogenesis. May be required for the transmission of the dpp signal and for a morphogenetic movement of the medulla in the brain that reorients the second optic lobe relative to the first. Plays a role in determining proper dorsal cell fates leading to the formation of the dorsal appendages.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKTETGSNNNNTTVVNMDFDMYPSISGKQQDPVREVVMKYIDYFLPDASGTSAVAIDNKIEQAMDLVKSHLMIAVREEVEVLKERISELMDKINKLELENSILKSNIPQETLQQLQLQLQLAAPPATPAIQAAPAVQSVVAPAAAGQAVQQQAAGAVAVTGVATSPASAVVPTSIPNGSAENGSSAVESAAVSVEQQVQQVTSAAAAAASVVTANGPMS
The following text describes a protein:
Function:
Bcl-2-like protein which contributes to virulence by preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B.
Sequence:
MRTLLIRYILWRNDNDQTYYNDNFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK
The following text describes a protein:
Function:
Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MVSGIICKAVVLVFGMLYPAYYSYKAVRTKNVKEYVRWMMYWIVFAIYTVMETIADLTISWFPLYYELKIAFVVWLLSPYTRGASLLYRKFLHPLLSSKEKEIDDYIVQAKEKGYETMVNFGKQGLNIAANAAVTAAVKSQGAITERLRSFSVHDLTAVQGDETSENRPFPPFPDAQKKPRASVSDSSGFGSLRKDSGDDRTDEDVEVNSEDEVYSQKGIRRSQSVRSVKGIKGRKEIRYASLKHKPKKRPQLYF
The following text describes a protein:
Function:
DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
VSFRLVMFRPFVGEVLVGKISGYDEKGLHVSLDFFNDICIPGHLMQYGTARALDGRWMLKTEDGDELYLDLDDEVYKICFFFKQIQSNCHCLYAHGQLDCYADTILGKH
The following text describes a protein:
Function:
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1. In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism. Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated RIGI ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Also binds poly(A) and U6 snRNA. Inhibits the integrated stress response (ISR) in the infected cell by blocking dsRNA binding by EIF2AK2/PKR and further phosphorylation of EIF2S1/EIF-2ALPHA. Stress granule formation is thus inhibited, which allows protein synthesis and viral replication.
Subcellular Localization:
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Domain:
The dsRNA-binding region is required for suppression of RNA silencing.
Sequence:
MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRDWSMLIPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGAIVGEISPLPSLPGHTAEDVKNAVGVLIGGLEWNDNTVRVSETLQRFAWRSSNENGRPPLTPKQKREMAGTIRSEV
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Sequence:
MTMITQMELIGDSKVAIADGEVDAISMCQEIAHSYDQDNIDDAFMLVDLDVIFERFLLWKREMPMIEPFYAVKCNTDRVLVRTLAALGAGFDCASREEIDIVMDMGVRAEKIIYANPCKTRSFITHAKEKNVSMMTFDSVEELAKIAHLHPDAKMILRIAVSDPTARCPLNLKFGVDPVTKAPHLLVHAKELGVNVIGISFHVGSGCNDPTAFREALTHARHLTELGRGLGFDMNLVDLGGGYPGTLQQTSFEDIAAVIRSAVDEFLPPEFGVRLIAEPGRFFAAAPFTLVCNIIHATEVSAEKITKRPEDVDHRGFMYYVNDGVYGSFNCILFDHVDPVGAPLFDEIVEEYPSTIWGPTCDSLDKIEDQKMMRMMSVGEWIVYQNMGAYTCSASTTFNGFQRPNAVYVISRKNWARISTSPNV
The following text describes a protein:
Function:
Multifunctional protein that includes general (non sugar-specific) and sugar-specific components of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport.
Subcellular Localization:
Cytoplasm.
Domain:
The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain; In contrast to classical PTS systems, the fructose-like PTS has no requirement for HPr and Enzyme I; PtsA combines a IIA domain with an Enzyme I and a HPr domains.
Sequence:
MALIVEFICELPNGVHARPASHVETLCNTFSSQIEWHNLRTDRKGNAKSALALIGTDTLAGDNCQLLISGADEQEAHQRLSQWLRDEFPHCDAPLAEVKSDELEPLPVSLTNLNPQIIRARTVCSGSAGGILTPISSLDLNALGNLPAAKGVDAEQSALENGLTLVLKNIEFRLLDSDGATSAILEAHRSLAGDTSLREHLLAGVSAGLSCAEAIVASANHFCEEFSRSSSSYLQERALDVRDVCFQLLQQIYGEQRFPAPGKLTQPAICMADELTPSQFLELDKNHLKGLLLKSGGTTSHTVILARSFNIPTLVGVDIDALTPWQQQTIYIDGNAGAIVVEPGEAVARYYQQEARVQDALREQQRVWLTQQARTADGIRIEIAANIAHSVEAQAAFGNGAEGVGLFRTEMLYMDRTSAPGESELYNIFCQALESANGRSIIVRTMDIGGDKPVDYLNIPAEANPFLGYRAVRIYEEYASLFTTQLRSILRASAHGSLKIMIPMISSMEEILWVKEKLAEAKQQLRNEHIPFDEKIQLGIMLEVPSVMFIIDQCCEEIDFFSIGSNDLTQYLLAVDRDNAKVTRHYNSLNPAFLRALDYAVQAVHRQGKWIGLCGELGAKGSVLPLLVGLGLDELSMSAPSIPAAKARMAQLDSRECRKLLNQAMACRTSLEVEHLLAQFRMTQQDAPLVTAECITLESDWRSKEEVLKGMTDNLLLAGRCRYPRKLEADLWAREAVFSTGLGFSFAIPHSKSEHIEQSTISVARLQAPVRWGDDEAQFIIMLTLNKHAAGDQHMRIFSRLARRIMHEEFRNALVNAASADAIASLLQHELEL
The following text describes a protein:
Function:
ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation. Is required for efficient abscission during cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST.
Sequence:
MLGSGFKAEHLRVNLRLVINQLAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLLAQFGLIQSMKELDSGLAESVSTLIWALCRTNQIGTVNDRLMHNLSVEAPSKILVERYLIEIAKNYNTDLIDVGFTDDVKKGGPGRGGGGGFTAPVGRPDGMVPMPMPMPMPMPSANTPFSYPLPKGPSDFSGLPMGTYQAFPNIYPSQIPMTLMLIRISLLHRLLVLDPSQKPLQSFLPDLRITMTTLSYQSCHLCQTHYQLHLLVPAPQHLKTLTLMIFPRGLKS
The following text describes a protein:
Function:
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Peripheral membrane protein. Nucleus.
Sequence:
MDVGVSRAPPAMSKTLKKKRHWSAKLQECAVSWGGSGELVSVVEVRGGAELGEFPYLGHMVMDALVCHAGRLPSSGDVLLEVNGTPVSGLTNRDTLAVIRHYREPVRLKTVRPGKVLNTDLHHYLSLQFQKGSVDHKLQQVIRDNLYLRTIPCTTRQPRDKEIPGVDYNFITVAEFRELEESGMLLESGTYDGNYYGTPKPPAEPSPVQPDLVDQVLFDEDFDTEVQRKRTTSVSKMDRKDSAAPEEEEEEERPPMVNGVGEHKDKADWRRTVPSYSQSAGAMDWRAWGSQDESQEPLPKNWEMAYTETGMVYFIDHNTKTTTWLDPRLAMKAKPPEKCEEGELPYGWERIEDPQFGPYYVDHINQKTQFENPVMEAKRKLSTDPPTGASPQPEAAAPPEVMEPPAPGARGFTRDPSQLHGTFVHTTLKKSLHGFGFTIIGGDRPDEFLQVKNVLPDGPAAHDKKIASGDVIVEINEACVLGKTHADVVQMFQSIPVNQYVDMVLCRGYPLPEDSGSNEESAGGAASSTDTSLPPSTSTPQDPHYTIPDGANVSRQVASVPPISNGRLNQPHPVHQHLPQAQDAPDPTLLQPELVSVPLVKGPGGFGFAIADCPLGQKVKMILDAQWCRGLLKGDVIKEINRQNVQTLSHSQVVDILKDLAVGSEVSVLVLRGGQTSPVKSLKPVTAPVSHTVSQPVLEQAPLPVPQQLPHPPSHHHLQQQQQEMISSTETLTQSDVTPNSLPVSSGTLRSSSPKPDASELYLRSKAILDSKPPNTKELDVFIKRNQESGFGFRVLGGEGPDQPVYIGAIVPYGAAEKDGRLRAGDELLCIDGIPVKGKSHKQVLELMTNAARNGHVMLTVRRRLAHADVAGEEANGPQSQQVSSSPKMPRVEAPNSGLPTRPESFDVTLHRRDNEGFGFVILTSKNKPPPGVIPHKIGRIIEGSPTDRLGQMKVGDRISAVNGLSIMELSHNDIVQLIKDAGNTVTLTVVPEDDNAPPSGANSAKHSPSAHHRAVGQQPANHQDRNGDAEVKNGVSPAEMGALIPSGPKQGCFVVELERSQRGFGFSLRGGKEYNMGLYILRLAEDGPALKDGRIHVGDKIVEINGEPTQGITHTRAIELIQAGGNRVHLLLRPGQGRVPDHTSKGKASIPTSSFPRLSASEEQPTSPSSSSSKTSTPNEIASAERRVAGSPGGEQDYRRNISPSRRANRSDSKSTSPKRANEGVTVHAERSHSGSMEDMSRERQVENRSRSPRKGSKRDQETFQPSRHLEEPSSPRRPGGQQPSAEVKDRRLQGEDASTTECGDRSWENAENAHRRAKKAEKEAAPKSHRDRAGSDAGTLNQRSARERADKHQGANGDVSRRDPRGSSSSAQDPNCNGTATSKKAPITPGPWKVPSSAKVQSQTEPAYADV
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MARPEDTESEEDPDGDWEPGTTGRTGRAKGAQADRTKEAGAQKKHKKKATAYASKDGEGYSWEEEYKRSWDVLREDESGSLESAVNQLIANKRRRVIRDTTSIQRGIIRHLCLIIDVSLAMTDRDLRPNRLDMSLTYAKEFVTEFFDQNPISQLCILITKDAIAERLSGLSGNPLDHHKALSNKAKLTPSGEPSLQNSLEMARASLSHLPSHGSREVLVIFGSLTTCDPDDINKTLENLEKDRMRVSMVGLAAEVRICKEICKRTQGQYGVILNEHHFKELLFEAISPPPIAKSTTNGPKTQSSSLIQMGFPNKITHDAHQVDASTHSFCACHSKLQSTGFICPRCGSKNCEIPTNCSVCGLTIVSSPHLARSYRHLFPVSNWIEKNANSLSHQTFKCFGCDKELQVNKASQTNDESNGNSNNATNANNPSINLYHCPRCKNMFCYECDIYHEQLGLCPGCC
The following text describes a protein:
Function:
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEIRFAIPKGSLEDATFKLLERSWTKVNRKSRTYRVYLDDPKIIVKMLRPQEIPTLVNEGLYDVGITGKDWVGETKSDVEPILDLEYGKIRLVIAFPDNYRYKNLDAMIADYAKKKKTLRLSSEYLTTASRFIKSCKSYKKYFGNKDPQIVTPWLRIGTNKSVQIHLSFGATEAKPPEDVDAIMDVTETGTTLKQNKLKIVDEVLTSTAHLIVNKKSLKDKAKREKIFDIVTLMRGAVHGKKYLHIYLNVEEKNLPKLLKQIPSLKKPTISPLSEAGWHGVNTIIKKSDFHKIIPKLRKIAQGLVVHEPRQILELEEIKRDEEN
The following text describes a protein:
Function:
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MMWSNFFLQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTEFWVELNTYKANGSAVCEAPHQRAVPYLPDTTGHEANCTYFKFFTTGENARIFQRTTKKGENFSPPAGRQVGEMLTGVAGVRLRAVLSPAGLLLLVSLEVFRHSVRALLQRVSPEPPPAPRLTYEYSWSLGCGVGAGLILLLGAGCFLLLTLPSWPWGSLCPKRGHRAT
The following text describes a protein:
Function:
Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, axon.
Sequence:
MSSVKVAVRVRPFNQREISNTSKCVLQVNGNTTTINGHSINKENFSFNFDHSYWSFARNDPHFITQKQVYEELGVEMLEHAFEGYNVCIFAYGQTGSGKSYTMMGKANDPDEMGIIPRLCNDLFARIDNNNDKDVQYSVEVSYMEIYCERVKDLLNPNSGGNLRVREHPLLGPYVDDLTKMAVCSYHDICNLMDEGNKARTVAATNMNSTSSRSHAVFTIVLTQKRHCADSNLDTEKHSKISLVDLAGSERANSTGAEGQRLKEGANINKSLTTLGLVISKLAEESTKKKKSNKGVIPYRDSVLTWLLRENLGGNSKTAMLAALSPADINFDETLSTLRYADRAKQIVCQAVVNEDPNAKLIRELNEEVIKLRHILKDKGIDVTDVQETPGKHKKGPKLPAHVHEQLEKLQESEKLMAEIGKTWEQKLIHTEEIRKQREEELRDMGLACAEDGTTLGVFSPKKLPHLVNLNEDPLMSECLIYYLKEGVTSVGRPEAEHRPDILLSGEAILELHCEFINEDGNVTLTMKPNASCYINGKQVTTPTVLHTGSRVILGEHHVFRYNDPQEARQSRHNLAAIAEQPIDWKYAQQELLDKQGIDLKADMEKKMLEMESQYRREKVELEQKMYHQTREYESMIENLQKQVDLAQSYISGGGSIWEGERMLTSSLLEFPEELKWTSDQKRVVLKAAIKWRYHQFTSVRDDLWGNAIFVKEANAISVELKKKVQFQFALLTDTMYSPLPPDLLPPGEDLTLRPYPKTVVAIQVQDLKNGATHYWSIEKLKQRLEAMRDMYETDAEMSPADGDPMMDALMGTDPFYDRFPWFRMVGRAFVYLNNLLHNVPLIHKVAVVNEKGEVKGYLKVAIEPVQKDEVINQKKGVRQTAKLHFRKEDFLKSHKNGETSDSDALAFPEHMQEEVEFCFRVVVLQAIDVADTYSDVFCQFNFLHRHDEAFSTEPMKNSKSPLTFEHTQNLHIKMSKTFLHYLHHFPIIFEVFGHFQPKSEQFNFERQNSALGRRLSTKLTFQQPSLVISTPVKSKKANAPIQNNNASVKSKHDLLVWFEICELANNGEYVPTIVDHAQGLPTHGIFLLHQGIQRRIKITICHEKGELKWKDCQELVVGRIRAGPEWAGGDDVDVLSLGLFPGTFMEFSMDDRTFFQFEAAWDSSLHNSPLLNRVSNYGDQIYMTLSAYMELDGCAQPAVVTKDLCLLIYARDSKISAASRFCRSLVGGISKSPEMNRVPGVYQLCLKDGSDSGSPGAIRRQRRVLDTSSAYVRGEENLGQWRPRGDSLIFEHQWELEKLTRLQQVERVRLFLRLRDRLKGKKNKGEARTPVSPCDPVCAIPESIKLDEKDKGIVGKVLGLIRRKIPMNKDPPTGNKAQELSDESGSNSITSPVSDKSLIKSSRSSDLLCRQKSKSDQNLASNDDIVDNLGGMKRSLSGSRILQLNILVPEVLEERVGVVVSKKGYMNFLEEKTQGWTRRWVIVRRPYILLFRDDRDLVIRGIINLANARIEHSEDQQAMVKVPNTFSVCTNQRGFLMQMMPGDEMYDWLYAINPLMAGQMKLHGNQNGTTLKSPTSSSSIAAS
The following text describes a protein:
Function:
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MEFVAALRLCLWLWLWPGLGPGLGPGPGLGHPQPCPQGAQLGGPLRLGALLPRAAALQRRVRRALARAISEGAWGPEPGLELGLELGPELELEAPAPPARDPASLAAWLCRLLARPGLAALLAFPESRPELLQLHFLAASLETPVLSLLQLDARLPPATPNPFHLQLDWANPLETLVDVLSSVLRAHAWKDIALVLCRIRDPGSFSDFWTQRTGLAPQMTLELSRLPGALARLQALAGEPPPVTAAILFGCDANRALQVLAAAPPGPRWLLGTPLEARELPIQGLPPGLLAFGGESQPLLEDLTQDAAGLVVQAVGRAVHAHPEQILSPSVVSCTSPRLSRPESWGRRLAGFLANASFHGRTGHMWVTATSQVHIQHHFQVWSLLRDPRGAPAWVTVGHWQDGRLEPAAGGVWPGAGGLGGRMPPRSPLLENEVGPQKLRVVTLVEHPFVFTREVDEDGHCPAGQLCLDPGTNDSAVLGELFAALDEPGNGSVPRDLRKCCYGYCIDLLEQLAEDLSFAFELYIVGDGKYGAWRDGRWTGLVGDLLAGTAHMAVTSFSINSARSQVIDFTSPFFSTSLGILVRTRDTASPIGAFMWPLHWTMWVGVFVALHLTALFLTLYEWRSPYGMTPHGRNRLKVFSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFGLLVLSSYTANLAAVMVGEKTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKKNFPEMAEYMLPILFQEGNLPCVLSAGYGIGLPRNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVIAVTETLQMGIYHFSGLFVLLCLGLGCSLLTSLGEHIFYRLVLPRIRKHAKLQYWLHTSQKIHRALNTSLEQQKNQKAEPEPAPEPSCNPPGQQSSRNSLRPAVKGERRVRFQEPGMEGPDLQLTNGRLPQQQPVGQPEAVRPQSPPLAAAAAAPATTTTTTQSELKALEQRIEGMREQLRAALLRKSELVLLLGRDLPPRSRLLLPPQEISEDS
The following text describes a protein:
Function:
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Sequence:
MQFQFPLQKALQTSQNGISVISASNSRRNCYLDEVIDRMGEASAIAQQLKQIITTASKFYGSDQRIYLKADGKNCLGLLKVGKKNLFYRDYSGSIKEMQPLCVLDFYVHESVQRMGVGKELFEEMLKSEQIKPEKLAYDRPSQKLIGFLNKHYNLNQYVPQNNNFVIFNQYFGQGTQPIAQGRSQKYSRNSQIDQLDIMVQQISQNKTNQQQLPQQKLGYQMSTPWAIDNHTNIYNNINSQRTNVYKIN
The following text describes a protein:
Function:
Involved in galactan degradation. Part of the ABC transporter complex GanPQS involved in the uptake of galactooligosaccharides. Responsible for the translocation of the substrate across the membrane (Probable).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNSLISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFSRFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNTYLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVLSSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGLTAGGTKG
The following text describes a protein:
Function:
RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing. Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity.
Subcellular Localization:
Nucleus.
Sequence:
MVLFSPLRRKKSKSRSRSHERKRSKSKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYSGPKFNSAIRGKIGLPHSIKLSRRRSRSKSPFRKDKSPVREPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVAASALAAAASVQPLATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLLVPSRR
The following text describes a protein:
Function:
May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.
Sequence:
MRILEEDLKRGLVKLRVDNLNDIYWLASIIEEGDLITMKTLRRVKQEGIRADSGERIPMILTIEVDKVKLDPYSSRLRISGVVRVGPDKFGIQGQHHTFSVDEGSSLTIVKKEWRKTHLEILKRAESMSEKGEVLLVAMDDEGATIAKAGSMRVEEIAYIRSRLPSKMDTRGREGEERRYFSEILDTLRELYSKIKPRAIVVGGPGFFKDRFLSYARAKDPEMGEKMREGDASNATFSGVLEMIRRGEADKVLRELDLAKDMAAVEEIFELLSKNSDLVTYGVDEVLEAVNQGAAEIVLISASVFFDPDMRDKVFSLIEGCERTRAEFRIIDSTSEPGEKLDAIGGVAAKLRYRI
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MASAAPELDVQDLRLQELIRGSMPDRPPSSSSSRVPPLSDDEIGRFHCAVCMEPKLVFDRFRATPACAHEFCVACVVSHIEARVADGNVPVPCPAAGAGCPGAMHPEACKKLLVMDVFDAWCVALCERAVGPGRARCPYRDCGELVVLDAGCGAAVGEVPEEATCPGCSRAFCLLCEEPWDDRHDGGQGCALDRLAVGRSWMRCPSCRAMIDRIDGCKSMLCRCGSVFCYGCGSSRAEGMCRCYASRREDFIPLDAGFELIGAGPSAGLSSTLGKDAVM
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEGERQPPPDSSEETPSATPTFIIPKKEIHTVPDMGKWKRSQMKTGPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVTSG
The following text describes a protein:
Function:
Component of the type VII secretion system (Ess) (Probable). Required for the secretion of EsxA and EsxB.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MVKNHNPKNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFIDAELTELRDSFQIHYDINDNHTPFDNIKSFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDELFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFDALVEGNLELHKGTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVLLIAFLAFLYFSVMKHNERIEKGYQAFVKDDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQTNKQGLEKDKKENLLNNVTPNSNKDYLLYWMELGQGHLDEAINIATYLDDNDITKLALINKLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQEENEKKQKEQAQKDKEKRQEAERKK
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MRNVWLIVPFALLAAFSGETWAQADRDLYIDSTESSGNYPVDDDDYSSGSGSGIPAHDDDEDNVVLTTVQTLISSPSSEMPYVDTTTLKTQTKMAPETKEPGEVESTNTVLVHENKNIIQTATHTENLFHRTEVLAAVIAGGGIGFLFAVFLILLLVYRMRKKDEGSYDLGERKPSSAVYQKAPTKEFYA
The following text describes a protein:
Function:
DNA polymerase II participates in chromosomal DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MSTRLESGTRVGWLFNYHPTTEVLQEEEDAFTGEGAQRAVLVLLFQDLAGDTFYVHLHYDPYILVQAVEGHEREVELGLMSTFGQQIISEIVAVEKEDLDLVNHLSGKKRVYLKVVFRNVQDLTTVRGRLEKTVKLNASLGSENPLRSQFSGSLGDAMAKTFAEDPLYSAAGSGRWMDWVQDIREYDVKYHMRVAIDMKVYCGLWYDVTVTEGGARVQRCDDSRYAPAMPRVIAFDIETTKAPLRFPQPEVDEVYMISYMLDGRGYLIINREIVTEDIAPFEYTPKPEYEGFFDTFNEENEAATLRRFFDEMRKYKPNVYVTYNGDYFDFPFIHARALYHGMNMRNEIGFTQMADGAFLNKQIPHLDCFYWVKRDSYLPQGSQGLKAVTKYKLGYEPIEVDPEDMLPLAQSQPQRMASYSVSDAVSTWYLYQKYVHPFIFSLATIIPMPPDDVLRKGSGGLCESLLMVQAEANNVVFPNKKEIERERFYEGHLIDTETYIGGRVEALRSGVYRSDIPMTFDMNPDTYQSLMDDVDEALRFTLEVENGVKVEEVTNLEEVRAAVLAKLTNLRDRPHQQEKPFIYHLDVGAMYPNIILTNRLQPYAIARPDVCAGCCFNSPNNEAQCKRVMSWKWRAELFTAGRYEFQRVKAQLENESFAAGVIEQANLAAVQKKVYGNRKGNVLEGTSYERKDDWKKNQSSLKGAGGAGYRQESRQQQREAADALLQRELGADRAGGGGTSDSDDDADDGPKAYHKLNENTQFNMLKRRLSEYSRKAYGKIHETREVMRSNVVCQRENSFYVDTVRLFRDRRYEYKAALKTWKKRLDAAKDSDERKVCQSRCVQMESLQLAHKCILNSFYGYVMRKGSRWSSMEMAGIVTYLGATLIQMARSLVQQIGVTLELDTDGIWCCLPNTFPENFTLTTTNPSKPKISISYPCVVLNKMVHDRYSNHQYQDLVSTGVYKTHSECSIYFEVDGPYLAMLLPASREEGKSIKKRYAVFNPDGSLAELKGFELKRRGELMLVKDFQSQVFRRFLDGSTLADAYASAAVVADAALDMLESQGEGYDTEEILEKITESSNMTRRLAEYPESQKSLAITTARRIAEFLGPQMVKDKGLACHFIISRMPTGRPVTERAIPVTIFRADPAVRTHFLRKWTADATVPSELNLKTLLDWDYYTARFSACVQKIVSIPAALQSLPNPVPRVEHPDWLEKRIRHRNSRYRQVSLLGMLSKAQVKNETLAGVSAAAAAAAAVRVDEDEDVVVLKHGGGAGAVEGELQDLEDIVDGAGSSTVRHAPKTQKAGAARAGERRCAAGADAEADWDEDNADCEGESEDDMERLQREADAELDALAHDVKQRYFAPKSANALDADFFADRGAKRWLAQRKDTWLQRARLRRELALENGLSEVALGGENSDAAALGLATVPDAAGMSSPFIDLKSRALATVWNVLEVRDNEESPGTVQVLAALEHSLYSFRVQVRRTVLLDADPALRLEAFDATEVSGRVLPRRAAAGRLYQVNVPPGEEGEQCLNALHVMEGVRQIYEEHRTRVDAFVEQLGCCVSVDSARHLRNARRRPPSKRELFGIDEMNMHTYTNYLSCGAADRAVFVFHAVTEQRGLIATVYPQTNTAFVVFIQPAEAAKPVINWGSICAESAKRLHTSTPEPIQVTSAVAVDQRAAWRQVHQHLSAALESTKAPLLAVLQSCQPTSTLLHQRALPVGLPYLRVLGAAEDERLLSDPFRWTRLLARRLFERFFASLLWVEERLALSRVSGIPLCNIAQDSCVHVLDVLYSRALHRRHHVLWCSSDPLITFDTVEERPREVCMTGGYTSWCVEFSLSRLDVVALLFSQAIEEGDDPNARVLSDRGVSTHFNILRDLVADLLGQAMENILADTLLNNVARWLRDPASSCYEPRLVELLSSLAHRALTGILLRLAKLGGRAVKVDGSSVTVLTSKYSLQEAVSFARFMTASLQDQPMLLLLSLQPLRYWCPYVVLDPCDYAGLFITEDAIKLKDGEEPTRSDLHVAHQLTMASRLPSRVRSTFAKRVVETLYQLNASTRHVYCGTVADHTVTLATRHEHLTRRLLQDSQKLFEGDLQTEIMDEVQRVTDTRDLYTEEEHAAHERGELTLWSSGAVALEYAKCVCRVLELIPCNGAVGKVRNNCMRLCGISPFSAQSQFQADPFLAHRLQSVTCSFCNSHILIDLLVRRKSVTSPFTCTACAAPIAAASMEGTLVRHVSQLLRVYNQQDFVCTKCREMTTTYVAERCCGALVGKAAPVEGELRAVHHIAKIQGFAWLAESVEAALLCT