lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Immediate early (EI) protein that functions as a transcriptional regulator of cellular and viral mRNAs mainly by interacting with several general transcription factors thereby disorganizing the preinitiation complex at certain promoters. May additionally help to regulate levels of histones in virus-infected cells by interacting with host ASF1. By inhibiting host transcriptional program, IE63 plays a major role in the ability of VZV to overcome the innate immune response to the virus.
Subcellular Localization:
Host cytoplasm. Host nucleus. Virion tegument. Note=During the first stage of infection, IE63 is mostly expressed in the nucleus and also slightly in the cytoplasm, and during latency, IE63 localizes in the cytoplasm quite exclusively.
Sequence:
MFCTSPATRGDSSESKPGASVDVNGKMEYGSAPGPLNGRDTSRGPGAFCTPGWEIHPARLVEDINRVFLCIAQSSGRVTRDSRRLRRICLDFYLMGRTRQRPTLACWEELLQLQPTQTQCLRATLMEVSHRPPRGEDGFIEAPNVPLHRSALECDVSDDGGEDDSDDDGSTPSDVIEFRDSDAESSDGEDFIVEEESEESTDSCEPDGVPGDCYRDGDGCNTPSPKRPQRAIERYAGAETAEYTAAKALTALGEGGVDWKRRRHEAPRRHDIPPPHGV
The following text describes a protein:
Function:
Serine protease which, in males, acts as a promoting signal during mating to activate sperm.
Subcellular Localization:
Secreted. Cytoplasmic vesicle, secretory vesicle lumen. Note=In males, partially colocalizes with swm-1 in vesicles near the apical membrane of cuboidal cells. During the spicule insertion stage of mating, secreted by the male vas deferens and transferred together with sperm into hermaphrodites where it spreads into the uterus.
Sequence:
MRPRIIVFLFQVLVVIKGTKLKYYNDELCGRQSTYTSFMLTDAAGNTGNPTHLAPWAVQIRVKARKGDFEVICGGTLITLKHVLTAAHCFQKHFGAKKEGGEENSMSGRYCESNQRFTDSEILTRTVVTVGAMCTRLEQKYGCVNEKQNGKTLKISRFAIGDFYKTHCEQGNDIVILELESTIDDVEGANYACLPFLPEVNIQSGANVTSFGWGSDPGKGFDNAAFPMIQVLTLATETLATCEENWGTSIPFDSFCTAEEEDKNVCSGDSGGGLTFHQSDSAREFIIAIVSYGSDCVQLIGGSEPRSQINTDVRKHQKFIVNFINQA
The following text describes a protein:
Function:
Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MCLLSFFLACTSSYNLTNRDIPYLFSDMEHKPFFAILYSDWCPHCLEHNELFMQLEKKYDGDSRFGLVRINCDNFNHICKKFPDSFTPGLYWVIDSPDRAEGYFGTLDLPSIISFIEKHLGELIVEVQNISQYENLLTTYKDNSIFVYQKAKDHGDSDKISDIVFKFKNYPTIFANLKFTLKEDTEDSLFFNINPSTNISTIYDGPYETELLKIFINKYAFPPISPLSALFFEHAITNNYNVLLLADEEPYFVDNFTRIVTENKLEMRAIHFRCVSFPKFCLDLLIQTGNGPQIIINNPKKHYEWYYKDELESSQIINWINEVQSGKRRAAGPGGGFIGFITNLYDDFHRKGPVALILFLSIFAVLAAIFLLGTVQSIVERRRLHYHKLE
The following text describes a protein:
Function:
Protein that helps load RecA onto ssDNA during transformation. Required for DNA transformation. Not required for DNA uptake but for a later stage of transformation. Thought to interact at the cell pole with newly imported transforming ssDNA which it binds cooperatively, protecting linear and circular ssDNA from nuclease action. Forms bridges between DNA segments. Favors the loading of RecA onto ssDNA and formation of RecA-DNA filaments, triggering RecA-catalysis of ATP-driven homologous DNA pairing.
Subcellular Localization:
Cytoplasm. Note=Localizes to the cell poles during competence (By similarity).
Domain:
The regions responsible for dimerization and for DprA-RecA interaction partially overlap, it is suggested that when RecA interacts with the DprA-ssDNA NPC it rearranges or disrupts the DprA dimer, leading to nucleation of RecA on ssDNA.
Sequence:
MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDCYPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGKTIAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCERAMEEGRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDVLAEFEF
The following text describes a protein:
Function:
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MVLLYSQASWDKRSKADALVLPFWMKNSKAQEAAVVDEDYKLVYQNALSNFSGKKGETAFLFGNDHTKEQKIVLLGLGKSEEVSGTTVLEAYAQATTVLRKAKCKTVNILLPTISQLRFSVEEFLTNLAAGVLSLNYNYPTYHKVDTSLPFLEKVTVMGIVSKVGDKIFRKEESLFEGVYLTRDLVNTNADEVTPEKLAAVAKDLAGEFASLDVKILDRKAILKEKMGLLAAVAKGAAVEPRFIVLDYQGKPKSKDRTVLIGKGVTFDSGGLDLKPGKAMITMKEDMAGAATVLGIFSALASLELPINVTGIIPATENAIGSAAYKMGDVYVGMTGLSVEIGSTDAEGRLILADAISYALKYCNPTRIIDFATLTGAMVVSLGESVAGFFANNDVLARDLAEASSETGEALWRMPLVEKYDQALHSDIADMKNIGSNRAGSITAALFLQRFLEDNPVAWAHLDIAGTAYHEKEELPYPKYATGFGVRCLIHYMEKFLSK
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MGEMLLGELRKDVPLVILRPSMVTSTYKEPFPGWIENLRTFDTVPIDMVVNAMIVAMAAHVNHPNSGIIYHGTSSASNPVKLHQIVDWSVEYFTKHPYIDKDGSIKPRDFKLLTSDRSFQKYIAIHYKLPLKALKIANMLLCQALDGLYTDFSRKLQIGTLFSDLFKHYSLSKAIYDDSNLKNLLNIYKENADDEAQVFFFNPSSINWKDYYMNTHLPGLVKYAIK
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase. Has no effect on the stability of the DELLA proteins.
Sequence:
MAVEARRINLFPSQFIPNKRQVMGSLDGNGVVYGSQVGQRGLVSENLMVPFYSSAFVDPAPAKADSGLTYNLPVARKRARDESVMMSFPGNFSFLGQDISLQIQQQQLEIDRFISQHMERVRLEIEERRKRHSRRIIAAVEEALMKRLKAKEEEIENIGKLNWALEERVKSLCEENQIWRDLAQTNEANANALRNNLEQVLSQVKTEQRQSRISPCPEYIEMEWAEEAESCCGSTSGGDGDCDRENEEKESREMDDRNMRWCRNCRKEEASVLLLPCRHLCLCTICGSTLHTCPICKSNKNASVHVNLS
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MANTDRPALPHKRAVPPSRADSGPRRRRTKLLDAVAGFGVTLGSMFKKTVTEEYPERPGPVAARYHGRHQLNRYPDGLEKCIGCELCAWACPADAIYVEGADNTEEERFSPGERYGRVYQINYLRCIGCGLCIEACPTRALTMTYDYELADDNRADLIYEKDRLLAPLLPEMAAPPHPRTPGATDKDYYLGNVTAEGLRGVRESQTTGDSR
The following text describes a protein:
Function:
Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation. Promotes also the degradation of other substrates such as CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus, nucleolus.
Sequence:
MEPQPGGARSCRRGAPGGACELGPAAEAAPMSLAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALESLTETQVSDFLSGRSPLTLALRVGDHMMFVQLQLAAQHAPLQHRHVLAAAAAAAAARGDPSIASPVSSPCRPVSSAARVPPVPTSPSPASPSPITAGSFRSHAASTTCPEQMDCSPTASSSASPGASTTSTPGASPAPRSRKPGAVIESFVNHAPGVFSGTFSGTLHPNCQDSSGRPRRDIGTILQILNDLLSATRHYQGMPPSLAQLRCHAQCSPASPAPDLAPRTTSCEKLTAAPSASLLQGQSQIRMCKPPGDRLRQTENRATRCKVERLQLLLQQKRLRRKARRDARGPYHWSPSRKAGRSDSSSSGGGGSPSEASGLGLDFEDSVWKPEVNPDIKSEFVVA
The following text describes a protein:
Function:
Converts sphingomyelin to ceramide.
Subcellular Localization:
Secreted.
Sequence:
MAFAQLVSALILSSFFLTVTPTEVPESVTNEIKELFKTGQAPKNLAKDLENFRMPRLFREGMENTYEHPVICFFCNLLVDLAIGERRLGASREVLAKEIEFICVHLGIESERVCTGVIDLNIDVFLYIVDNYPNLDSHRVCGSVLQSLGCSPGDNFEWSIELPSGSSPVRPKPNDTLDSFKILQLSDIHYDPNYKPYGNADCGEPICCQTDQGEPSSPENTCGYWTDYREADVPWHLIEETVRQAKTQEFEYVYYTGDIISHRVWETSIRNNSQSISDLFTYFKQSFDVPVYPVFGNHEPHPLDLWPTESVKDEKFSVQWLFELVSGPWSELVGQDISETVLKGGYYTVSPKPGFRIIAINGNLCYTYNWWLIFNDVDPYGQLQWLTETLLEAEKNNESVHILSHVPSGTSESLSVWGREYSRIIERFANTITGQFNGHTHRDQFHVYYNSSNPTQPIGTAFNGASVTPYTASNPSYKIYDVDSTTFDLLDYEEWTFNLTLANSKSSNESPDWYKLYSFTEAFGVDNLSPVEVDKVLYKMAENHSLLDDYFLFKFRNGDAGIKDGCDDKCKKDNLCEIATTVYGVDVHCNRFTDLYDKGQ
The following text describes a protein:
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MAGGTAPPRGSAAAAASMRRRRTTSGAASGGAAGTMLQFYTDDAPGLKISPNVVLVMSIGFIAFVAVLHVMGKLYFVRREA
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
Sequence:
MTMPDLDTIEVSDIKQWRYCPRVVWYTYCLPAIRPKTDLMRQGAASHRAEEDREERRSLRTYGLKTGERFFHVYLRSERLGVRGILDLAIAVPNRSDPAAKIVVVDYKDSEQDAGPHFKLQVGAYALLIEETWGLPVETGWIYHIPLRKAEKVPISPQLRKNVIETIAAVQKAIRTEALPPPPSSRALCVNCEFRRFCNDVV
The following text describes a protein:
Function:
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as a coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3 (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (By similarity). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes. ASXL1 and ASXL2 are important for BAP1 protein stability (By similarity).
Subcellular Localization:
Nucleus.
Domain:
Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which may be required for an association with nuclear receptors.
Sequence:
MREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSECSEESSDGQSDSHSSDNSSSSDGGSNKEGRKSRWKRKVSSRLSHPPSPPSGCPSPTIPASKVISPSQKHSKKALKQALKQQQQKKKQQQCRPSMSISNQHLSLKTVKAASDSVPAKPGQMKRTKCADIDVETPDSILVNTNLRALINKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVELWKEQFFENYYGQSSGLSLEDSQKLTASSSDPKAKKTPAEQPKSILPSEASPVRIVPVVPQSECKEEAVQIPSPSQKEENQDEARPDSKSPEPVLASASNTNELITMKPIKSPKDEGLLEQKPVACAEQESEKENHVTTTSRNNKSENQEALAISPSKSKNAGLQKPIIKPVAEASPLNPDMKMPPATVTDQIQESLKRKSSLTDEEATSSWEKRPRITENRQHQQPFQVSPQPFLNRGDRVQVRKVPPLKIPVSRISPMLFSTSQVSPRARFPISITSPYRTGARTLADIKAKAQLVEAQKAAAAAAAAAAAAASVGGTIPGPGPGGGQSPREGGERKIAGGGSAGSDPVSTNGKGPTLELAGTGSRGGTRELLPCGPQPETNMPGQAQPPGISGAQLQQTSSVPTGLASSGACTSVPLPAHIEISNSEKPNLHKATATAASPCHLQDPRSCRLEKALSPTGPPLISGASTVYFVADGTVEPKAGSNKNAPKPSALAKTTAPAPLDMTSSPVTTASLEKLPVPQISGTATSTGSAPSSSTLPAASSLKTPGTSANMNGPISRTSSSIPANNPLVTQLLQGKDVPLEQILPKPLTKIEMKTVPLTTKEEKGIGIFPGISVMESSSREEVNGRQAHLAIPQLGKPLQSKQLSQVPRPVFTAKDRKDPCIDTHQYREGLSKTTQDQLFQTLIQRAQRQSVLSFVPPSQFNFAHSGFHLEDISTSQKFMLGFAGRRTSKPAMAGHYLLNISTYGRGTENIKRTHSVNPDDRFCLSSPTEALRMGHADYKNTTGEISSKEDESDEDRVGDEQEPISVKEEPWASQSSGRHPHHGEASSTNDCLASKNGKTEAPVSEQTTLGQENYIFSRGQASDEKSLPRDFIPAAHKQMTHAVRGKTVCSSPELFNSTALSLPADSPTHQPLLLPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAIPGSQVSSNVGDVMSFSVTVTTIPASQAMNPSSHGQTIPVQTFPDDNSIEDTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCVSCLVVR
The following text describes a protein:
Function:
Accessory component of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKPLVSPGLAKACTGLSLIGIVFLLVLSYLFSIEAETLMHDLVGSGLTGKQVAKTCLGAVVIYAVFFLFCGSQVIVSRYQKPVRI
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSGIASTVYNAVLRSNTTMLFTVFGAAFGMQLAFDTGSDKIWSTLNKGRQWKDIKQRYMEAAEDDE
The following text describes a protein:
Function:
Component of the CENP-A recruiting complex that ensures the integrity of mitotic spindles through maintenance of kinetochore factors mis6/CENP-I and cnp1/CENP-A. Links mis16 and mis18 to recruit CENP-A through interacting with non-sense-mediated mRNA decay (NMD) factors and the SWI/SNF complex. Also links mis18 with the CCAN/mis6/ctf19 complex to promote CENP-A assembly.
Subcellular Localization:
Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes at the centromeres during interphase, but not in mitosis.
Sequence:
MDLMPLEKARAIEIAFDNVFHNTKIPDNLQQFDAILKRLERRRFIPTENQKPRVYETELLVLRFREFGVKDNHNHPINLHSLRSKSLIRAQGKKLDLHNRVFLRRNVRAVKM
The following text describes a protein:
Function:
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).
Subcellular Localization:
Cytoplasm. Preautophagosomal structure.
Domain:
The GxGxxG motif is important for the function, possibly through binding with ATP.
Sequence:
MSFTPFSSFLEASFFQTLAAKKLNEYKLDDSPKRVSAEYTWQQGRLVFDSDSFSDRDSHCKGVVECPGTLLNYNTIEEFKGADKKALLAEWGDKMLSGAIMNGSIFRNPEILNSFLLITFCDLKKYIFVYWMGVPCLNTKWDLQEVADEGNYTNLSTRIPALGESFVVIDPDDNVTPFSELEYVERSEDPTIAFLSPTSPENTPWTVRNICLMLHILGFKSATMILVGREKNRFLEWKRGDGELGAWTGWEKNSAGKLLPKQTNLGPLLNPLQLASQAVDLNLKLMKWRIAPELDLDTIKHTRCLLLGAGTLGSYVSRSLLAWGVEQVTFVDNGTVSFSNPVRQPLYKYVDCLDGGKPKAETAAEALKEIYPAVKTSGITLEVPMIGHSTTSSSEKRVHQQYDELVSLIKSHDAVFLLMDSRESRWLPTVICAALKKKCITAAIGFDSFVVMRHGVEGVNDLGCYFCNDVVAPTDSMNDRTLDQQCTVTRPGIAPIVSGYGVEILQAMCQDEPSAPHQLRGFLHNFSTVKITGQRFKCCSACSPVIVQEWKDKTWGFVKKALNERGFVEELCGLAELQRGVDELDFGEGEGSEEEWEM
The following text describes a protein:
Function:
Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-2, cnnm-4 and cnnm-5 to regulate Mg(2+) homeostasis. Promotes postembryonic gonad development by regulating Mg(2+) levels, probably via AMPK signaling.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MSKTPWALGLLIFLLTFTSPLSSSPVRSTDNSTSSKGLLNVNSSVILEPSILPSSASKPESLHLSKVRVSGLRLEAHASSTENIVLGHNKKHNVVVVPNKNVRVVLFGQNFQDIGALTFTADGSCKDLAHFFEADFSSMTPIRVVVEMSFPKTTESKDSFKLCVSEKFYANPQFVIVEDPFTMVTTEIPPVDEYMPKWLSWICLLILLCFSGLFSGLNLGLMTLSPYELQLYIASGTEQEKRDAGRILPIRKKGNQLLCTLLIGNVVVNVGVSLLMDQLVGSGFAVLVAATSCIVVFGEIIPQALCVKLGLPIGARTIPITQVLLFLMYPLTWPISKVLDIFLKEELTRSLERNKLVEMLKLSEKSIIGGQSDEFKMVLGALELYDKTVAHAMTRYEDIFMLPHTLTLGAGMVTQILDMGYTRIPIYENDRKNIVALLFVKDLALLDPDDNHNVMKIASIYNHEVRRVLVDMPLRNMLEEFKRGEYHMALVERLVEQEDKDPIYELCGLITLEDIIEEIIQCEIIDETDAVCDNVHRKKRQRKRNHDMSQIVNTAHAKCAINIQMLAVTIQVMSTCHKIFSSNYILPTILEKLIRKNCKKVETTQFSCLKEVGVVQPKPAVLFTKGEFSNKFIMILSGRAVVTIGKEEMRLEAGAWHSFGTEVLDAMAEAIERSLNQSTSRSTVSLNTEITNNSIGFIPDFDTVILYECVFCEITAADLLLAYNSSQIMQNNTKMQVVRSNSRISLIEEIPKDAVSTPIRNGSVKLRTVSEGETVHLLPKNMECHFNKQEKYEEEEE
The following text describes a protein:
Function:
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular Localization:
Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton.
Sequence:
MAAAAAAAAATEQQGSNGPVKKSMREKAVERRNVNKEHNSNFKAGYIPIDEDRLHKTGLRGRKGNLAICVIVLLFILAVINLLITLVIWAVIRIGPNGCDSLEFHESGLLRFKQVSDMGIIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVEKNKTSITSDIGMQFFDPRTQNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDLNIKVDGRAIVRGNEGVFIMGKTIEFHMRGDVELKAENSIILNGTVMVSPTRLPSSSGGDQSGSGDWVRYKLCMCADGTLFKVQVTSHNMGCQVSDNPCGNTH
The following text describes a protein:
Function:
Threonine aldolase involved in threonine degradation to glycine. May play a role in the removal of L-allo-threonine.
Sequence:
MVTNVVDLRSDTVTKPSDAMRAAMAAADVDDDVLGADPTARRFEAEMAALLGKEAALFVPSGTMANLVSVLAHCDVRGSEVILGDASHIHVYENGGISTLGGVHPRTVPNNPDGTMDLARIVDAIRNPDGALLYPTTRLICLENTHANSGGKCLSVEYTDKVGEIAVNHGLKLHIDGARIFNASVALGVPVHRLVKAADSVSVCLSKGLGAPIGSVVVGSEAFIDKARILRKTLGGGMRQVGVLCAAAYVAVRDTVGKLADDHRKAKALAEGLKKIKQLTVDSSSVETNMVFFDIVDPRISPSKLCQVLEQRNVLAMPASSKSVRFVIHYQISDSDVQYALTCVEKAVEELLKGGTKLEHLTNGTAKNSYWH
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MALTRDKRDLFFGVGALLALMALFQFLSYDLLIPAKDMPHKSKIEHFRRPHFMNATLVEKPARCRGALCTFMDITIKSDYVGQIVFLLNDIKRPKTAENFRALCTGEKGKSSSRTNLHYKGTAFSRVVHNILVQGGDIHKGKALEEEKESIYGAAFAQESNVDELHERGLLATAGRGKTGSEFFITLDSVAELDGQFVVFGEVVEGMDVVDKINSVAVNSDGEPTAPILISNSGQI
The following text describes a protein:
Function:
Transcriptional cofactor. Required for controlling cell proliferation in the seam cells, a stem cell-like lineage, acting in concert with Runt-related transcription factor 1 rnt-1, perhaps by repressing expression of cyclin-dependent kinase inhibitor cki-1. Represses expression of rnt-1. Regulates male tail development. May play a role in vulval and/or uterine morphogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKRTTTDQQSSFQTDYFLTQLSHFTEAKFSLFEHAPLSERRERFRVHVERDEMPLTFCKTGINIPVKLEWSQTNGNEISFRSRPLVFNGIWVKVIGAMNSESLEGRVRFERFQREKRDRVISETFVFPEVEEEPIGLTDAEIAALRRDGLPI
The following text describes a protein:
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MVGSGAPQRGSAAAAASMRRRKPSGSGGGASGGAAGSMLQFYTDDAPGLKISPNVVLVMSIGFIAFVAVLHVMGKLYFVK
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MSAIFNESELSGLDAHSAFGNNETSSFQKKKRRIDENSQMSVNDLVDDGEEEEDDDDDEEEPSYVQDQNMAKVFEKFLKTFSEKKSEEDDDDGDSIWKDSLNFDFPSNLEIAKDSHYVLLLFSILQNSYSRNKVLIVDMKHVLMWEPTDKNRFDIGSQLYMYIKRHFLRILDIFEKKVQLLAESINPIKTKEVGKICLRFYNKKNPIHSLRSLRCEMLGEMISVRGQVTRTSDVRPELTLAAFKCNECGNIINGVKQQFRYTQPSKCPSASCSNMSDWSLVLEQSYFVDWQKIRLQEIAQESPPGSMPRNMDVILRNDIVDSVHAGDRIIVTGCLIVVPDIPTLMKPGDVPRSVARQLLKKNENSLVSQGLTGIKGVGVQDLNHKLCIYACQIEKLNSSKKDNNFDEQTQVDINCEEILNCDDLKWLRDIAMHPNTIDILAECIAPKIWGNLEIKKGALLMMTGGVQKITSNCKLRGDINMCIVGDPGTAKSEILKYVESFAPRAIFTSGKGSTAAGLTAAVHRDPDQGDTVLEAGALMYADQGICCIDEFDKMDEKDRVAIHEAMEQQTISITKAGIQATLNARASVLAACNPKYGRYDTLKTFAQNVNIPAPLLSRFDLFYTMLDCIDIDKDTSIANHLVSMHCGEEAEKHLRANAGKLDSVKLEIYLELSKRVKPLLTDEAKYKLIQYYVSFRNIEYSPGAQRSMRMTVRQLESLIRLSEAVAKLKFSHFVDVKHVEIACSIFKASMKKISNEKEINLDEEFDKVNNSLMGNKVNKLDQETENTEQNKKITTIKASEYQYISAIIFEIIKEYEFNNNNESITQDQLIETYLQVYAKAESSEQVDEWIYKLKKIINRLINQDIKLLSETNEDDPEKVIIRIHPNYAGPIVEGVSNKNTYGYNTFKNYQTQEKAPEDDVDFQEEIDNF
The following text describes a protein:
Function:
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities. The function of trans-aconitate methylation appears to be in reducing the toxicity of this spontaneous breakdown product of cis-aconitate. The role of 3-isopropylmalate methylation is unclear but may represent a metabolic branch at 3-isopropylmalate, where some of the material is taken in the pathway leading to leucine and some is taken in a pathway to the 3-isopropylmalate methyl ester, a molecule that provides a signal to switch from vegetative to invasive growth in response to amino acid starvation.
Miscellaneous:
MISCELLANEOUS: Present with 937 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTFSASDFNSERYSSSRPSYPSDFYKMIDEYHDGERKLLVDVGCGPGTATLQMAQELKPFEQIIGSDLSATMIKTAEVIKEGSPDTYKNVSFKISSSDDFKFLGADSVDKQKIDMITAVECAHWFDFEKFQRSAYANLRKDGTIAIWGYADPIFPDYPEFDDLMIEVPYGKQGLGPYWEQPGRSRLRNMLKDSHLDPELFHDIQVSYFCAEDVRDKVKLHQHTKKPLLIRKQVTLVEFADYVRTWSAYHQWKQDPKNKDKEDVADWFIKESLRRRPELSTNTKIEVVWNTFYKLGKRV
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
Subcellular Localization:
Cytoplasm. Mitochondrion intermembrane space.
Domain:
The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation; The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters; The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
Sequence:
MSILSDFLKHPNLLQVTDGGPLVDGTNGVKGTRVVGSVSNARELRGADSLVGDVERAIIQVQETELLAEVCNTVFDVMKQNGEVIVFSQDLTTAQRKLRIAGFRVTEVAAEFPVRGIKLVNFGEKVALDLGVVADEDLIDEDGLLQEEDFEKPTGDQLKAGGCGPDDPNKKKRACKNCSCGLAEQEELEKMGQIAAEPKSSCGNCSLGDAFRCSTCPYLGQPPFKPGETVKISTVDDF
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Sequence:
MPLFFLYSFLIYLILFQCIRNYKHLSTLQLSNRGLVGNHVGSNLSYACWLGKLKNINNRKTFEINMIKKFINARDPFEPQDHLKDIPYKDELDKIQIRGRKIEMKSIFSPQGDLIPATLIEIMPNVIYRFLDFGKVGIAYGKPLDESRWILKPEIGQIAKVGCNLKNTCSLTLTPPQNFVLGQIIDVSYLYNYKYVNVRGLSKGKGFCGVIKRWGFKRGPMSHGSSHHRKPGSIGASTHIGRVLKGKKMPGKHGNKYRTMINLKLLGLNLERNEILVSGCIPGNRNSYVTVTATRDNKVNKYKYILDMLYKQEKNVK