lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position. Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling.
Subcellular Localization:
Mitochondrion. Cytoplasm. Note=Mainly mitochondrial. Translocates to the cytoplasm following TNFRSF1B activation.
Sequence:
MLSLLSTPRLVPVIARLRGLSGCMSCLQRRYSLQPVPVKEIPNRYLGQPSPVTHPHLLRPGEVTPGLSQVEYALRRHKLMALVHKEAQGHSGTDHTVVVLSNPIHYMSNDIPYTFHQDNSFLYLCGFQEPDSILVLQSCSGKQLPSHKAMLFVPRRDPGRELWDGPRSGTDGAIALTGVDDAYPLEEFQHLLPKLRAETNMVWYDWMKPSHAQLHSDYMQPLTEAKATSKNKVRSVQHLIQHLRLIKSPAEIKRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIYSMMLTLMGQKLKDLGIIKTSKESAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITVEPGIYIPEGDTDAPEKFRGLGVRIEDDVVVTQDSPLILSADCPKEVNDIEQICSRTS
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MQRIRRLAGVLAGVAFVLATTACTQAGAPPAAPQENPTVNNPSGARADLPSLAGKATVDLNTSKGRILLEVDGDNAPLSAGNFVDLVKRGFYNNLAFHRVVSGFVIQGGDPLGNGTGGFIDPATRQPRSLPLEIRATTGDGRPGEILYGQTFSLSGRNPRTQPPVLVHSRGALAMARSQNPNSASSQFYITLAETRQLDGEYAVFGKVLEGQDVVDKIQVGDKILSATVVSGGGDPVGGSAPG
The following text describes a protein:
Function:
Thioesterase that has relatively broad substrate specificity, hydrolyzing primarily medium- and long-chain acyl-CoA substrates to free fatty acids and CoA. Functions in the thioesterase-dependent pathway of beta-oxidation of oleate and conjugated linoleate ((9Z,11E)-octadecadienoate or CLA), which provides all energy and carbon precursors required for the growth of E.coli. Thus, supports growth on oleate or conjugated linoleate as the sole source of carbon by hydrolyzing 3,5-tetradecadienoyl-CoA, the terminal metabolite of oleate beta-oxidation via the alternative thioesterase-dependent pathway, and 3,5-dodecadienoyl-CoA, the end product of CLA beta-oxidation, respectively. Seems to be involved in 3-hydroxyalkanoate production in E.coli.
Sequence:
MSQALKNLLTLLNLEKIEEGLFRGQSEDLGLRQVFGGQVVGQALYAAKETVPEERLVHSFHSYFLRPGDSKKPIIYDVETLRDGNSFSARRVAAIQNGKPIFYMTASFQAPEAGFEHQKTMPSAPAPDGLPSETQIAQSLAHLLPPVLKDKFICDRPLEVRPVEFHNPLKGHVAEPHRQVWIRANGSVPDDLRVHQYLLGYASDLNFLPVALQPHGIGFLEPGIQIATIDHSMWFHRPFNLNEWLLYSVESTSASSARGFVRGEFYTQDGVLVASTVQEGVMRNHN
The following text describes a protein:
Function:
Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
Sequence:
MASENNGSRSDSESITAPKADSTVVEPRKIALITGITGQDGSYLTEFLLGKGYEVHGLIRRSSNFNTQRINHIYIDPHNVNKALMKLHYADLTDASSLRRWIDVIKPDEVYNLAAQSHVAVSFEIPDYTADVVATGALRLLEAVRSHTIDSGRTVKYYQAGSSEMFGSTPPPQSETTPFHPRSPYAASKCAAHWYTVNYREAYGLFACNGILFNHESPRRGENFVTRKITRALGRIKVGLQTKLFLGNLQASRDWGFAGDYVEAMWLMLQQEKPDDYVVATEEGHTVEEFLDVSFGYLGLNWKDYVEIDQRYFRPAEVDNLQGDASKAKEVLGWKPQVGFEKLVKMMVDEDLELAKREKVLVDAGYMDAKQQP
The following text describes a protein:
Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Sequence:
MTHCCSPCCQPTCCRTTCCRTTCWKPTTVTTCSSTPCCQPSCCVSSCCQPCCRPACCQNTCCRTTCCQPTCLSSCCGQTSCGSSCGQSSSCAPVYCRRTCYYPTTVCLPGCLNQSCGSSCCQPCCRPACCETTCCRTTCFQPTCVSSCCQPSCC
The following text describes a protein:
Function:
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in target proteins.
Subcellular Localization:
Nucleus.
Sequence:
MMRRKNNGKVGAGSTSSNSEVESRKEYLVEDMNIVKEMERSGEEVVGDRAESSNMDVSVDAIVGSEKTSADYYFDSYSHFGIHEEMLKDTVRTKTYQNVIYQNKFLFKDKIVLDVGAGTGILSLFCAHVGAKHVYAVECSQMADVAKEIVEANGYSNVITVLKGKMEDLVLPVTHVDILISEWMGYFLLFENMLDTVLYARDKWLVDGGIILPDKASLYLTAIEDAEYKDDKIEFWNDVYGFDMRCIKKQSMMEPLVDTVDQNQIVTNCQLLKTMDISKMSSGETSFTSPFKLIATRNDYVHALVAYFDVSFTKCHKLMGFSTGPRSKATHWKQTVLYLDDVLTISEGEAIIGSLSVEPNKTNPRDVDIVLNYSFHGERCQISKTQYYKMR
The following text describes a protein:
Function:
Vesicle trafficking protein that functions in the secretory pathway.
Subcellular Localization:
Endomembrane system; Single-pass membrane protein. Golgi apparatus membrane.
Sequence:
MPSGFRLDTDGWTKEFDECKQLAQETLQLIQERNLRHPNGGPEASRLSAAARKKLGTLGVQLDKLLRWLDSPEADSLSEPEKNRRRDLIHDLRGRREGMQMSIKRSTGAADRDALFSGAGPSSGPLPPRETEATAELDNRGLLGLQQAVMRRQDEELAAMEKTVASTKHIALAIGEEVDLQTRLLDDLADDVDVTQSRLKAATAKVKQLMRDSGNCRLGVCVFILIVTLVVVIILTVKLARFL
The following text describes a protein:
Function:
Binds to MCB elements (Mlu I cell cycle box) found in the promoter of most DNA synthesis genes. Transcriptional activation by MBF has an important role in the transition from G1 to S phase. It may have a dual role in that it behaves as an activator of transcription at the G1-S boundary and as a repressor during other stages of the cell cycle.
Sequence:
MSAGSAVSATQIYSAKYSGVEVYEFLHPTGSIMKRKADDWVNATHILKAAKFAKAKRTRILEKEVIKDTHEKVQGGFGKYQGTWVPLDIARRLAQKFEVLEELRPLFDFTRRDGSESPPQAPKHHHASRADSARKRTTKSPPLPHGQLDALPKRRGRPPRARKLSDVANVAGQTQVYSDFPRPSIPVSSISSNQLPSLQSTLHRSISIEHNRNKAPPQPNHKYEELDIEDGLSSDIETSICTNMVYAGHSNARLPMNTSLLPDKEEPGLSSSLPSSPSEFSAPMVFDTQRMGSATSPLGSMLPRYMAPSRPRTSELDQKANEYLSKLVDYFINCEVQNNGAVPMELLNPPHSSPCIDSWIDSEHHTAFHWACAMGTLPIVEALLQAGASPRALNQAGETPLMRASLFHNSYTKRTYPRIFQLLQDTVFDVDSRSQTVVHHIVKRKSNTPSALYYLDVLLSKLKDFSPQYRIETLINAQDCKGSTPLHIAAMNRDKKFFQTLVGNGALSTIKNHDGVTADELINNRFVKTIQPTQRGNYHENRASHSPLNSASAAGGMVPASLIHTGDMYPSQSATSVSRAIPEVINLMKDMADSYQFLYEDRNQEVQDVVKMLKSMSATVTSLDMKVLEILEVKDMNNITYEMDSLKENIAGLKQKLSEKQKVLVSLLEKSQRVTLRKCVEEEKKAIESVIAAPADDATHSSKETLADDLRELTVLQLRRKHKINRLIELLCGNSKIHKFRKMISQGTDMDISEVDNFLDVIFQQLNEDEENTNNGGHTNYNGHVSCAILDTVEGYGIENIENKRGTSQNDGPAK
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MPHAVTIATPGLQALILCGPGSSFPTFTANPDENPKALLPIANRPMVWYPLDFCYRAGITNITLICPPTAQQAIQTALNTNPFLTSLPYPRPDLLAPKDLDQNTGTAEILRLPEVQETVTSDFLVLPCDLVCELGADKLLQAWMVKSASLTDLLDDKRSENVPPKRSGGLGVWYQTKTATPIKGEETDFLATVPLPSSSVSPPRGSLFPNISKVVYSTPTDSLKDLLEEEKGFPIRHALLNQHPRVRMLTTHRDAHIYIFPHWIMDFVRENDRLETIGEDVLGWWAKAGWQKGLSKKLGLDAILGQSSTAVSNTDGKTSPVGSHSPKDSTAKHPTGSQIHDAVSASGTTNLEGPVRPVIRTGDKPGHEETESTNEKQNDSTIPPMLAYIHPSSSTDSTTSTPLIRRVDTAQLLLQISLQLAKLPSIEEVGSAEAASPFAHTRKVAYPEGVKPRTTITKQDSLVADNVTVQEKTSIKECVIGANCQIGEGAKLSQCLLMDGVVVGKNCKLTKCILGKRSEVGEGCTLMECEVQENLLVEAKTETKNEKFMSSSGLEATEEDLAEEDDDEENDGNGNDDDDEDEEDDESAEE
The following text describes a protein:
Function:
Required for the synthesis of the beta-hydroxy acid moiety of rhamnolipids.
Sequence:
MHPYFSLAGRIALVTGGSRGIGQMIAQGLLEAGARVFICARDAEACADTATRLSAYGDCQAIPADLSSEAGARRLAQALGELSARLDILVNNAGTSWGAALESYPVSGWEKVMQLNVTSVFSCIQQLLPLLRRSASAENPARVINIGSVAGISAMGEQAYAYGPSKAALHQLSRMLAKELVGEHINVNVIAPGRFPSRMTRHIANDPQALEADSASIPMGRWGRPEEMAALAISLAGTAGAYMTGNVIPIDGGFHL
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Sequence:
MLPPRPKQVPRRWIASLGQSSCRPCVVNNNIRTAVATVGRGRGAVGVGRYVTTQTSLTSAGSRPSSVLLAVPARPVIDITPCCPRLFQLQIRGKKTRTVVQLNDLPLPSVVESAVNGPLLVVEESVQEEGTSTARRKRIKRTILQLDQLPVSQTTLTSDPILDAQRDINPNEDMDSGKSKRGRRRIVKLDDSSTTPVAMLDEALLPVKEATEEAADVEQNEPSTQRKRDKTRTVRLKEIPQGALLPDESFPPRQQEDQEPAYPAVIQQHRHNMQKFDNCVLLTRVGGFYEMYFEHAEEVGPLLNLKVSQKKTSGGPVSMAGFPFFQLDRYLKVLVEDLNRHVAIAEEYRNSPSEQIKSGGLMHNRRVTRIVTPGTLIDENFMDPYANNYIMAIHLPSDSLEGSSSFQEALNTGTGQKKESLVGLAWLDLSTGNFYTQQTSLIALGSVLLRVSPREIVLDKSLESAEGHDILSVLNEERYPVTYSPQSENIQTLKDWAPMLDAKIPTETVIRFTDDEIKAGNVLLHYVTDRLQGLSMKLQPPIRHDNMQIMTIDKNSMRSLEIKKTMREGFFAGSLLHAIRRTVTKSGARLLNEWLSAPSTSLSVINSRLDLITRFISNPDLSDAITVLLHRSHDTQRLVQKFALNRGDADDLLRLASTIKATEDIVNHLKSTMSSEDNNPEEDDCLTKLIDRISLEQPLKLAKRIWDAIDEEGLVQQHQLEDSETGEMLALAQEIVKGEGTEEDGRALLPKGATAKSNRARAELTQNRNQQEKDLSKDNRKMSLRNYYGEDNQVWIMKPKANRALAKLHAELRSLQEQKEKLTEEFRAKYAAPSLTLNWKAGLGHVCVVRGRDARLAMGETSRRTRTSSSSSNSMSDPIADTTDADAADADGEPIPEPVPEPESLSTLRTLSTTRTTRTFHHPLWTSLGESLDHVRLRIRSEETALFSSLRSNVVTLLIKLRRNALVLDELDIATSLARLATEQNLVRPILHDSSTTNGSQGMGTRTVIVGGRHPTVEPSLLSRGMTFQKNDCLIGSPGQGAIWLITGPNMAGKSTFLRQNALITILAQMGCYVPADYAELGIVDAIFSRVGSADNLYADQSTFMVEMMETAAILRQATPRSFVIMDEIGRGTTPEDGTAVAFASLHHLLTVNKCRGLFATHFHAVGDMLKEQGLVVEDGASSAGASWGVAMYCTDVEEDESGGFVYVHKLRKGMNRQSHALKVARLAGLPEPAIKIAQQVLAVQGVVA
The following text describes a protein:
Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVRVKYRYILVQIRCNNREDTAPVTIESNTLLKYIRENIERYYGEFGIASMLRTNVIYFNAKTHLCIIQAMHGPHRFITSILPLLTVAGPEIARYRTLYVGATLMQCNKFILKYQQRYINKTLGEYRGMGQKLKMIEDVTKMRRL
The following text describes a protein:
Function:
Catalyzes the production of hydrogen sulfide (H2S) from cysteine. Is mainly responsible for the degradation of cysteine to generate H2S, a regulator of stomatal movement and closure.
Sequence:
MEAGERRNGDSMSHNHRAPKKPRLAGLLTESDIDSEFAHHQTGVARINNGSFGCCPGSVLEAQREWQLRYLRQPDEFYFNGLRRGLLASRTVISDLINADDVDEVSLVDNATTAAAIVLQKVGRCFSEGKYKKEDTVVMFHCAFQSVKKSIQAYVSRVGGSTVEVRLPFPVNSNEEIISKFREGLEKGRANGRTVRLAIIDHITSMPCVLMPVRELVKICREEGVEQVFVDAAHAIGSVKVDVKEIGADYYVSNLHKWFFCPPSIAFFYCKKRGSESDVHHPVVSHEFGNGLPIESAWIGTRDYSSQLVVPSVMEFVNRFEGGMEGIMMKNHDEAVRMGLMLADAWGTNLGSPPEMCVGMVMIGLPSKLCVGSDEDAIKLRSYLRVHYSVEVPVFYLGLRDGEEGVKDKDSGLITAYVRISHQVYNKTEDYERLRDAITELVKDQMTCQNLPAL
The following text describes a protein:
Function:
Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms.
Subcellular Localization:
Secreted.
Domain:
BAC5 sequence consists almost exclusively of X-P-P-Y repeats.
Sequence:
METQRASLSLGRCSLWLLLLGLVLPSASAQALSYREAVLRAVDQFNERSSEANLYRLLELDPTPNDDLDPGTRKPVSFRVKETDCPRTSQQPLEQCDFKENGLVKQCVGTVTLDPSNDQFDINCNELQSVRFRPPIRRPPIRPPFYPPFRPPIRPPIFPPIRPPFRPPLGPFPGRR
The following text describes a protein:
Function:
Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc-) glycan attached to glycolipids and N- or O-linked glycoproteins. Fucosylates distal type 2 LacNAc and its fucosylated (H-type 2 LacNAc) and sialylated (sialyl-type 2 LacNAc) derivatives to form Lewis x (Lex) (CD15) and Lewis y (Ley) antigenic epitopes involved in cell adhesion and differentiation (By similarity). Generates Lex epitopes in the brain, presumably playing a role in the maintenance of neuronal stemness and neurite outgrowth in progenitor neural cells (By similarity). Fucosylates the internal type 2 LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (By similarity). Can also modify milk oligosaccharides in particular type 2 tetrasaccharide LNnT (By similarity).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein. Golgi apparatus membrane.
Domain:
The donor-binding domain adopts a Rossman-like fold involved in GDP-beta-L-fucose sugar donor interactions; The acceptor-binding domain adopts a Rossman-like fold consisting of six-stranded parallel beta sheets characteristic of the Toll/interleukin-1 receptor (TIR) fold family. Interacts with the LacNAc unit of type 2 LacNAc and H-type 2 LacNAc structures. It contains the catalytic base Glu-137 which deprotonates the hydroxyl group of GlcNAc while forming bridging interactions with the donor sugar to position the catalytic machinery in the active site.
Sequence:
MTSASKGILRPFLIVCIILGCFMACLLIYIKPTNSWIFSPMESASSVLKMKNFFSTKTDYFNETTILIWVWPFGQTFDLTSCQAMFNIQGCHLTTDRSLYNKSHAVLIHHRDISWDLTNLPQQARPPFQKWIWMNLESPTHTPQKSGIEHLFNLTLTYRRDSDIQVPYGFLTVSTNPFVFEVPSKEKLVCWVVSNWNPEHARVKYYNELSKSIEIHTYGQAFGEYVNDKNLIPTISTCKFYLSFENSIHKDYITEKLYNAFLAGSVPVVLGPSRENYENYIPADSFIHVEDYNSPSELAKYLKEVDKNNKLYLSYFNWRKDFTVNLPRFWESHACLACDHVKRHQEYKSVGNLEKWFWN
The following text describes a protein:
Function:
Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation (By similarity). Plays a role in the formation of cell ruffles.
Miscellaneous:
MISCELLANEOUS: Recruited to PIP5K-induced vesicle surfaces in the absence of functional WASL.
Subcellular Localization:
Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Cell projection, ruffle. Note=Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity).
Sequence:
MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDKPKGAGASAGGYGGGGGGGGGGGGGGGGSGGNFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPILPPGGRATSAKPFSPPSGPGRFPAPSPGHRSGPPEPPRNRMPPPRPDVGSKPDSLPPPVPNTPRPVPSSLHNRGSPAGLGAPRPPFPGNRGAAFGAGSARQNPSGSSSPFPRPPLPPTPSRALDDKPPPPPPPVGNRPSMHREAVPPPPSQTSKPPVPSTPRPGLGSQAPPPPPPPSRPGPPPLPPASNDEIPRLPQRNLSLTSSAPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPINRNGSTARALPATPQLPSRSGMDSPRSGPRPPLPPDRPGAGAPPPPPPSTSVRNGFQDSSCEDEWESRFYFHPISDLPPPEPYVPTTKTYPSKLARNESRSGSNRRERGAPPLPPIPR
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MQSGDSDGQLAAAAAAAAAAGSSSAPGVPWWGGVCHLPQQPSAAPDKQVVASAAHNSTTGYDENGGDEPQHQQAQQNPALAGLPPPPGEYVQAAYPYSDPFFGGMMAAAYAGQGLVQPHVLGLQQARMPLPTEILEEEPVYVNAKQYHGILRRRQSRAKAESENRLIKTRKPYLHESRHLHALRRARGCGGRFLNKKTNKDNETETTTTNVTSNTSTGSRNRNTTNINAPSNRSESLSSGNLEASNPYHHVMAFSNGHHSLQQDSQLFHASAFHPISGDEGVQAVAAMQ
The following text describes a protein:
Function:
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Sequence:
MKRRVGIGGLQSSAATRNQYRLIGESLSVVKNDVMMAQLSTFRSQLEDFARKHKNDIRKNPTFRAQFHEMCSKVGVDPLASNKGFWAELLGIGDFYYELGVQIVEICLATRSLNGGLINLQELLDLLRLKRKNAREPVSEDDCLRAISKLKVLGSGFEVISVGKKKLIRSVPTELNKDHNAILELAQGQGFVTVEEVESRLSWSAGRAIDALDTLLEEGLAMIDDGHKDGKRRYWFLCVSSISAVVGADAIAI
The following text describes a protein:
Function:
ATP-dependent 3'-5' DNA-helicase. Has a role in the repair of UV-induced DNA damage in G2 via recombination-mediated repair. Also has a role in the repair of infrared-induced double DNA strand breaks.
Subcellular Localization:
Nucleus.
Sequence:
MTVTKTNLNRHLDWFFRESPQKIENVTSPIKTLDFVKVKVSSSDIVVKDSIPHKSKNVFDDFDDGYAIDLTEEHQSSSLNNLKWKDVEGPNILKPIKKIAVPASESEEDFDDVDEEMLRAAEMEVFQSCQPLAVNTADTTVSHSTSSSNVPRSLNKIHDPSRFIKDNDVENRIHVSSASKVASISNTSKPNPIVSENPISATSVSIEIPIKPKELSNNLPFPRLNNNNTNNNNDNNAIEKRDSASPTPSSVSSQISIDFSTWPHQNLLQYLDILRDEKSEISDRIIEVMERYPFSSRFKEWIPKRDILSQKISSVLEVLSNNNNSNNNNGNNGTVPNAKTFFTPPSSITQQVPFPSTIIPESTVKENSTRPYVNSHLVANDKITATPFHSEAVVSPLQSNIRNSDIAEFDEFDIDDADFTFNTTDPINDESGASSDVVVIDDEEDDIENRPLNQALKASKAAVSNASLLQSSSLDRPLLGEMKDKNHKVLMPSLDDPMLSYPWSKEVLGCLKHKFHLKGFRKNQLEAINGTLSGKDVFILMPTGGGKSLCYQLPAVIEGGASRGVTLVISPLLSLMQDQLDHLRKLNIPSLPLSGEQPADERRQVISFLMAKNVLVKLLYVTPEGLASNGAITRVLKSLYERKLLARIVIDEAHCVSHWGHDFRPDYKQLGLLRDRYQGIPFMALTATANEIVKKDIINTLRMENCLELKSSFNRPNLFYEIKPKKDLYTELYRFISNGHLHESGIIYCLSRTSCEQVAAKLRNDYGLKAWHYHAGLEKVERQRIQNEWQSGSYKIIVATIAFGMGVDKGDVRFVIHHSFPKSLEGYYQETGRAGRDGKPAHCIMFYSYKDHVTFQKLIMSGDGDAETKERQRQMLRQVIQFCENKTDCRRKQVLAYFGENFDKVHCRKGCDICCEEATYIKQDMTEFSLQAIKLLKSISGKATLLQLMDIFRGSKSAKIVENGWDRLEGAGVGKLLNRGDSERLFHHLVSEGVFVEKVEANRRGFVSAYVVPGRQTIINSVLAGKRRIILDVKESSSKPDTSSRSLSRSKTLPALREYQLKSTTASVDCSIGTREVDEIYDSQMPPVKPSLIHSRNKIDLEELSGQKFMSEYEIDVMTRCLKDLKLLRSNLMAIDDSRVSSYFTDSVLLSMAKKLPRNVKELKEIHGVSNEKAVNLGPKFLQVIQKFIDEKEQNLEGTELDPSLQSLDTDYPIDTNALSLDHEQGFSDDSDSVYEPSSPIEEGDEEVDGQRKDILNFMNSQSLTQTGSVPKRKSTSYTRPSKSYRHKRGSTSYSRKRKYSTSQKDSRKTSKSANTSFIHPMVKQNYR
The following text describes a protein:
Function:
Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Essential for coenzyme Q biosynthesis: together with FDXR, transfers the electrons required for the hydroxylation reaction performed by COQ6.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MAASVAWGGVNAGFLLRAARGAWASRPGGFWGLGEAAAPATTRTFRATGSRPAGEEEAGGPERPGDVVNVVFVDRSGQRIPVSGRVGDNVLHLAQRHGVDLEGACEASLACSTCHVYVSEDHLDLLPPPDEREDDMLDMAPLLQENSRLGCQIVLTPELEGAEFTLPKITRNFYVDGHVASPAQSTDRPERDVGSTQEATEMCVRLWWGQGPRWGRLPQAPENGGVASGGIQWECQ
The following text describes a protein:
Function:
Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Interacts with the CCAAT displacement protein (CDP2) to bind the tyrosine hydroxylase enhancer.
Subcellular Localization:
Nucleus.
Sequence:
MTSRDLGSHDNLSPPFANSRIQSKTERGSYSSYGRENVQGCHQSLLGGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPLHSSTMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYSSSKPAASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDTANHMGQM
The following text describes a protein:
Function:
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
Sequence:
MIGAVLAGGRGRRFGGDKLLFRISGKPLLLYTIERLEQAEKIDEIVLVASKENAEKLRDFGHDVVVDELMIGPMGGIFTALSLGDAFVVAGDMPLLVPEFIDFIVERFEEAKKPACVPRWSNGYLEPLHAAYSSSFRDFLEERIKSRNYAINQAIRESDACYIEIEKLPEGWRESFFNVNTREDLRRLTPLRTRDNPDTLR
The following text describes a protein:
Function:
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Domain:
Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
Sequence:
MSNIPDDKIREIRERAPILEVVSDYVSLRKSGANYQGLCPFHGEKTPSFNVNPARGIFHCFGCGVGGNAITFVMKMEGLSFPEAVKFLGKRVGVEIEDRPVTAAEKRRQDEREELYGIMDLAARLYREALERNEEAGAARRYLETRGVDRETSEAYRLGFAPDRWDYLSRHLQHRKVSMDLAERLGLVRRREGGGYFDIFRNRLLFAITDIHGRTIGFGGRVLDDSLPKYINSPESPIYHKSDVLFGVHLAKGALREQGSAIIVEGYFDHLALYQAGVRNVVATCGTALTEGHVKLLRRYAGKAYTLFDADSAGRKATVRAIDLFLAENFPAHVVELTQGEDPDSFVKKEGADIFRTRLAKARPAFDFLFRDLLGQVDAGTVEGKLKVANELAPRLAKLANPIERELYVKEIARVLGIDVRSLLRASGGAAGSRPDPLPRPTAERRPRGAGPEEMLLALMARSAEVADRVRRGEAAGLFRPELAPVADAILERHSRRVEIDWGELLELVASPEEKGRIAAFLVNDDHLADVDVHKAFDQCRQALERGSLKRLKDLARELAAADSDTPRYRELLAEIEALRNRKSQLS
The following text describes a protein:
Function:
Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
Subcellular Localization:
Cytoplasm.
Sequence:
MKEWNSFDKITKAKGMWLVDSKGHKMIDAVASMWCNVWGHSNPQLVRTITNQSKKLQHSSMFNITNEPAEQLADSLIKMSPGMHKVFYSDNGSSAMEIAIKIALQYWKNIGEKKTEIATVENGYHGDTFGAMAVGYVPQFFGKFKKQLFQTLQFPVPNNYRLPKGYTLSDYQNECLEKIEKKFSKNNNIAAFVMESGAQVAGGVIIYPKGFQRKISQLCKKYDVLFVLDEIATGFGRLGSMTQYQEQKSIPDIVAYGKMLTGGYLTMAATLANKKVYDSFSGEFNDWKHLFHGHTYTGNPLAASVANENIDMYKKNNLIKKVQKTSKVFEKYYDEISEIDIVGDIRHKGMLMGIELVTDRKKKTPIHPKKSINKIFYEIGKKNGIYLRTLGNIVMLVPPLAISEKELNSLLTRTIKTIQDAKSQVI
The following text describes a protein:
Function:
Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane.
Sequence:
MINLSHYLIGMAFYPAVMLIILSEAPKFAQNVETNTTTFNLSEIMFNFFIIVVFLWAWYHQHVATVILANLRKNKKGDVVDQGYRLPEGDWFNYLSSPHSTAEIIMYTALTLLLAKNTSWLYVYAWILSNQIETILLSHWWYLDRFKNFPPQRKALIPFIY
The following text describes a protein:
Function:
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. Also involved in the regulation of mitochondrial dynamics.
Subcellular Localization:
Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Synapse.
Sequence:
MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDVFGELFNEAHSFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFHRRTLPIPLHETYELCEHPPPLNILSPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQKQKNIDRPQEPEKVPRLPHDRRREWQKLAQGLELAEDDVDLHLNHKHIEIANGPASHFDTRPQAYGENIDGPFSLAALPFSQMNDLLNRVEDRVLVRPHEPPPPPPVHAPGDGKAMPQIISATPGLSENRPQSPAMGRTPGFASPSPPPPPPPLPPPPPPLPSALSASSLRSSISSTPPPPIPPPPPPPTTAIQTTVVPPPPTPLQIAPGVLHPAPPPIAPPLVQPSPSVTRVAQISENVPAPQIEAPGLPPPPPPPPLPPIAVPPLSHPAGVHPVASIVPGSHVALLPPSPPSQGPEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERVENDVATILSRRIAVEYSDSEDDSEFDEVEWLE