lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus. Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body (By similarity). Inhibits interferon induction pathways by interacting with host TBK1 and preventing the formation of dynamic cytoplasmic condensates that have liquid properties and that are essential for interferon production (By similarity).
Subcellular Localization:
[Phosphoprotein]: Virion. Host cytoplasm; [Isoform P2]: Host cytoplasm; [Isoform P3]: Host nucleus; [Isoform P4]: Host nucleus; [Isoform P5]: Host nucleus.
Sequence:
MSKIFVNPSAIRAGLADLEMAEETVDLINRNIEDNQAHLQGEPIEVDNLPEDMKRLHLDDEKSSNLGEMVRVGEGKYREDFQMDEGEDPNLLFQSYLDNVGVQIVRQMRSGERFLKIWSQTVEEIVSYVTVNFPNPPRRSSEDKSTQTTGRELKKETTSAFSQRESQPSKARMVAQVAPGPPALEWSATNEEDDLSVEAEIAHQIAESFSKKYKFPSRSSGIFLYNFEQLKMNLDDIVKEAKNVPGVTRLAHDGSKIPLRCVLGWVALANSKKFQLLVEADKLSKIMQDDLNRYTSC
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLYVSRILRLPTTRAIALSLHSRNAPLAASSLRRPFSSTNDEHDKFKSMLSSSSVRSPYADPTRTRASPDIVIAAPQKRQLSSENPPVESPKETVVRTERVEEERKVESPACPLPSKKAVAVEREPIKFVEEPVKAPAGEGKSADRLSHEIEEQYRMAQALPRGGVFRRFKDKWGLSIDESASAEEKKRQRTTRNTILGSVFVFGSAVVGFVSFCLYYGRAERDASGHAIKDEFTGSFFAPFSRIVKNMKAWRDYVVEPSREKLLPDPLPPGYIQPKYTIVIEMKNVLVAPEWTYKTGYRFKLRPALDYFLDVIGYPNFEVVIYTSESSMTADPVVNSFDPKQRIMYRLYRDCTKYMEGRHVKDLSRLNRDLTKVIHIDFDPNSFSLHPENVLRVPKWDGNMNDTSLVDLAELLKTIHLSDVEDVRPVLEYYSGFDDPAKEFRKRAIYMAEQELQAKTAQEQGDGNSLVKRYTGRLFGFRRHASA
The following text describes a protein:
Function:
ABC transporter; part of the gene cluster that mediates the biosynthesis of aspercryptins, linear lipopeptides built from six amino acids including 2 highly unusual and nonproteogenic amino acids, 2-amino-octanoic acid (2aoa) and 2-amino-dodecanol (2adol).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAGSCTIDEHNHFGPIVGDACYGGLDFTLYFEEAFLSIFPAATLILAATVRCFLVRSASLKVRGGWLHTLKLLLLAPYSISQLLLLAFWMRSGTPKTDLTIASTVLRFIATLPCGYLIHLQHHRSLRPSKIISIYFLLTLLFDIPLARTIWTIQGLRTVSAIFIAGTVVKALLLILETWEKRRLVRPMYASPAPEDWTGVINRSLFWWINPLLFRGARTSLSVGDLFHLESCMLPDPDGKHRVVMHWENVTNKDKAGAMVVPIAKAFKWDLLAGVFPRLCQSGFIISQPFLVRATVELFVYRDRPDSRSKATLLIGAYALVYGGIAIATATAQHKTYRVITMMRAALVDMIFEKSTAINAHKNDDSAALTLMSTDIERITHCGRYIHDTWASLIEIGIALYLLYNELDTAGIAPIIIAFGCTVTAMKIAMMAGERQNLWIEAIQKRVAITAEMLGSMKGVKISGLTDLLFNKIQALREHEILASQKFRSLLIAVVGLSNFNTLMTPIVSFTIYAMGSGDAPNEILGSARALTSLTLFNLFAVFIGTLVESISETAMALECLDRIRNYLAQEAHQDPREVNSSPVTEKTPCIEAFEVDVGWKNGDESILHRLSYRIERHSLTMIVGAVGCGKTTLVKAMLGEVNCLTGKMKVNCDRMAYCGQDAWLTNGSIRENILGGSPYDPPWYSTVVAACGLEKDFTELTAGDQTAVGSKGVSLSGGQKQRLGSLDVLTRAQALARALYSGVETILLDDALSGLDPVTDEHIFTQVLGPNGLARKQHLTVVMVTHAVHRLPYADHIIALNTDGTILVQGTFDDCCKRLDYIQGFAIAQPPAIQMKSAMPKAVEVTKAAPYSDEAISDARRSSDYQTYLYYLTTVPWHNWLVYFGLMAIFVFLQAFPTVWVTWWARDNDAQPNKNRSMRIGVYWMFGVLGACFLLATACFYMLKIVAKTASVIHSRLLRTVVNAPMSFFASTDSGTTLNRFSQDLELIDMELPLAVLQTCLALFLCVAQLIIIAVSARYITATIPLCVLVYCIIGTFYMRTSRQLRIMEIEAKSPLFSNFMELLNGLITIRAFNWAEQYKLRNRALLAESQRPYYLLYAVQRWLSLVLDMTVAGFVLVLMGIAVGTMHSTNASSLGLALVNVVSLSASVKALITDWTVLETSLGAVTRVKHFAESTESEDMVQERDLPPEDWTSRGTVEYKNVSAFYRDPSKPVLKNLSFRVHKGEKVAIVGRSGSGKSTLVSALFRMIELCEGTISVDGIDITTLRRQAIRSAIIGLPQDPLLLEGSTIRENVDPFDYCPDEAVINTLKRVGLWEILESKDGLETIASPELFSHGQKQLLCMAKAMLRHGNIIVFDEATSGVDPETDEMMQELIRSCFAQHTVLTVTHRLDTIIDYDRVLVMDNGILLESDPPRTLLSRPSVFRELYKSSRGWEEYERQERAEAEARRRERVEKERAEEELRGRRGLISEKEEPETVSAIREHWNVVNQLFGGIIPRAVPRTRSRSRDHSAERRESKRYSGGDWTGEGDGDGGDGGLGRRDTRRHLTGLAARGLH
The following text describes a protein:
Function:
Degrades hyaluronic acid (HA) exclusively into HA disaccharides (HA-2). Produced HA-2s confer anti-inflammatory properties leading to reduced immunopathology in the mouse model of acne.
Subcellular Localization:
Secreted.
Sequence:
MFGTPSRRTFLTASALSAMALAASPTVTDAIAAPGPDSWSALCERWIDIITGRRAARTSDPRARAIIAKTDRKVAEILTDLVSGSSRQTVLISADLRKEQSPFITKTARAIESMACGWATPGSSYHKDPEILSACIEGLRDFCRLRYNPSQDEYGNWWDWEDGASRAVADVMCILHDVLPPEVMSAAAAGIDHFIPDPWFQQPGSVKPTANPVQPVVSTGANRMDLTRAVMCRSIATGDEKRLRHAVDGLPDAWRVTTEGDGFRADGGFIQHSHIPYTGGYGDVLFSGLAMLFPLVSGMRFDIDESARKAFHDQVERGFIPVMYNGQILDDVRGRSISRINESAAMHGISIARAMLMMADALPTHRAEQWRGIVHGWMARNTFDHLSEPSTLVDISLFDAAAKAPRPGVVDAELLRVHGPSRPATADWLITVSNCSDRIAWYEYGNGENEWAYRTSQGMRYLLLPGDMGQYEDGYWATVDYSAPTGTTVDSTPLKRAVGASWAAKTPTNEWSGGLASGSWSAAASHITSQDSALKARRLWVGLKDAMVELTTDVTTDASRAITVVEHRKVASSSTKLLVDGNRVSSATSFQNPRWAHLDGVGGYVFATDTDLSADVATRKGTWIDVNPSRKVKGADEVIERAYASLHGHPPRSSSPWALLPTASRSHTMALATRPGVEPFTVLRNDGNRPGRASAGALLTKDPTVVTTLAFWKPATCGGVAVNRPALVQTRESANQMEVVIVEPTQKRGSLTVTIEGSWKVKTADSHVDVSCENAAGTLHVDTAGLGGQSVRVTLARQVTQTPSGGGRHDRA
The following text describes a protein:
Function:
Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MNPTHKQNPSTEDILRIIRDIMTDKKCEEVSILNLESVNSYLSYFVICTVNSAVQANAVAREVRKTLKEYKLSHKETDKTGTSATSGWTLLDFGEIIVHIMTPEKREYYNLDRLWRDAKRIEL
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease RIM13 via VPS32 to its substrate RIM101 (By similarity).
Sequence:
MPNIIWIPFRETQAVDLITGLGDTIEKQLNQPRDKFTADLKTANDLRNNILNPQPNASYLDHLTKYYAQLTYWTTKFPAGCDSLEFMWYGTLAYTANAAPVISQSLHFERCNLLYNLGSLYSQMGVNEGRQDADGLKMSFNYFQMAAGCFQILIENGLPDLESLNMRGLEYDTICCVRDLMLAQAQECFWQRSLLSGSRNSLVAKLAQQVSLLYDSALAWAQKSPQVRSEWVHHMTCKRQHFLAVAHYRMARDALDGCRYGEEIARLKAALNAIKEGTGKGMLRRYLVESVADDLNGIIDVVTEDLKRAEKDNNLIYLQSVPQTTALAPITPALMVKCTPPVELAKPIEFLTKDKLGLPLFVKLTPFAFHQALVLYSQECDKIVSSIESQLKNCTNSKNQALVEMALPGSLDSVEKPKGIPADIIAHSDQIKSERGLETTREAVKDVQRLAATARQELEAAKAVLDDERSEDEMLRRKNNSGWTRFDSKEAGAHLYTRLAELEQYLADAGASDKLVRGKLDEIDYLLSILNSGRSALENYLPSSVSGVRSPEVKRQVPHLRDLLNNLESLEIKRAQYMDRLSLKQQNDDIEPVLEYHMNKLIREKHANLRLTLADFEPITSKELEKYTVDQDWASEQKELQEEVLEKLDVANKDFRSSLDMNDAAIHRENAIQSLEVAYFSYQEQKDHLDAGRNFYNQLLGEISIFHKNCKQFVYERKMEGASLEHELSSMHLSEHEHSGGHSDTSSTPLAAPRAQRASNLSMWSPEDGIRFG
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MYAGQAWEQQVHKRDRITTSGTMGDCQRACFIRSSINIDQYFTVGNIVRSGETISSRGFSERIGGKGANAAVAISKAGERVYFSGLIDNQSTWLKDTLKAFQVDVDGLKICDERSKLPTGRAIIQVSHETGENAIVLVPGANHAPSEFWPELESILKPMKYSHVLLQNEIPIAQTLHTSKIAHSLGITTIFNPSPLPSPKEVTEVIDWSCIDWLIVNEEEARMLRNRATSRTRCDDQLECGEIPDLKQELAVLQELISFSMATFSIVITLGSRGSLLAFRHTPSVWIGVHTPPSAGKRPVINTTGAGDCFTGFLVAELIRLDKSPIPKDQLLERLKKSMQVASQAARLCVENHGTIDSYPTLEEVQTHSNVCS
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MGTNSPYPSTSYPSSTSSYMPQVPMPTLPSTSTTTTPTARPEVRVQGNFSPVQFKYKMPDIPESFEEVNSLSVAELKELHDNETKVVDLFSSLPQCQQLYQDRDKLNDATEQLARQNLDKQPMLELKKKELIEKVDEQNELRRAFDKSSQRQNDLMDQFKPAMIQANLKVAAQQAEEESDVIAEDFLEGRMEMDEFLQKFMEKRVLCHTRHAKEEKYQQLMANRPLRSTMTM
The following text describes a protein:
Function:
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Sequence:
MQLIKFFSDRRLTWSLIFSIGLHGSVVAALLYVSVEQMKIQPEIEDTPLAVTMVNIAEFAAPQPAAAAPEPVQETPAVPEETPPVLEETPPEPEELPEPVPVPVPEPVKPKPKPVKKEVKKPEVKKTQAPPDDKPFKSDEAALVANNAPVKSAPVASTPGLSTSAGPKALSKAKPSYPARALALGIEGQVKVQYDIDESGRVTNVRVLEATPRNTFEREVKQVMRKWRFEAVAAKNYVTTIVFKLDGKMEMN
The following text describes a protein:
Function:
Component of the RQC trigger (RQT) complex, a multiprotein complex involved in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation. Specifically recognizes and binds RPS20/uS10 ubiquitinated by HEL2, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes.
Miscellaneous:
MISCELLANEOUS: Present with 1710 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MTRKQAIDYAIKQVPQILPLEESDVKALCEQVLSTSSDDPEQIASKFLEFLGHEDLSFEFVMKFNELLNQNDKKEEKKTKNVHLEHTAPTSWKNESKQPTNNYINKKGDEKPKKLKDEKKSSTTRPTVQPSNQSTQSNPIKEKKEHRSKGKLQSLQEIDEAIKMLELRDSGSSKNCNCQGTRHPVFDIAPNCLHCGKVVCVIEGLNKGKCGHCHEQLISDNERTQMVEILNQEKNELNGSSSSLSNASNGANVPKKKTKTYKITSGMGKNLFAEQDKLFDFIERKRERERKRNEVLKLQEEKEESEAKERQASEHDHKAEENPELLAAQERLDRLLYFQDTSAERTKIIDNASDFDMNQEVGLWGSARERALALKKQQRNLRKWEKVEKERNGRREKYVVSMNIGSNGKVTMTEVPKDTENVIAGSDDDISDISDEEDISDLKHIHALKSEINTTKSLENLHLQSKAWDYERDKKQFDRPTYVKKNSDTAQQNRKTEEKAHDMQAYDLKSRVQVDQNADASVEQNILAVL
The following text describes a protein:
Function:
Plays an important role in the switch between viral transcription and genome replication. Once produced in sufficient amount, interacts with and inhibits the viral RNA polymerase that becomes unable to produce additional late transcripts. This lysozyme-polymerase complex in turn plays an active role in viral genome replication and packaging; Endolysin with amidase activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and breaking down the peptidoglycan layer.
Subcellular Localization:
Host cytoplasm. Note=The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane.
Sequence:
MARVQFKQRESTDAIFVHCSATKPSQNVGVREIRQWHKEQGWLDVGYHFIIKRDGTVEAGRDEMAVGSHAKGYNHNSIGVCLVGGIDDKGKFDANFTPAQMQSLRSLLVTLLAKYEGAVLRAHHEVAPKACPSFDLKRWWEKNELVTSDRG
The following text describes a protein:
Function:
May play a role in acrosome development and also in sperm maturation and motility.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. Note=Located in the cytoplasm of spermatocytes and in the acrosomal vesicle region of round, elongating and elongated spermatids. Detected in the main piece of the flagellum in testicular spermatozoa. Detected also in the connecting piece, middle piece and cytoplasmic droplets of epididymal spermatozoa.
Sequence:
MSCKTPPTLQELAENSLLKNQDLAISALDDIPSLFFPSLFKKACRNRYVGIIKAMVQAWPFPCLPLGAMISRKTAYRRILEIILYGLDALLSQKVPHSRCKLQVLDLRVMPLKLWNRLPVFGTAGCSENPAVVGHSGTEVKQPVKVLVDLVLKESPLDSTESFLVQWVDNRNGLVSLCCCKLQIWAMSMYYHRKLLEILDLDSVQELRMYCISNPVCLLNFAPYLGRMRNLRCLILSHLWQTFSMTPVEKQQVITQFTSQFLKLKCLQILHLDTVFFLEGHLDELFWWLKTPLETLSVIDCNLSKSDWFHISEFQCTSQLKHLNLKWVKLTHLSPEPLRVLLLKSASTLTSLDLEGCQMMDSQLSAILPALRCCTQLTKFNFHGNYISMPILRELAYNVVKQKSQQSKIRFIPSCSHHSGLEFEAISQPHIVFVDVDRTTGEQEQVLFYAICSGEYVL
The following text describes a protein:
Function:
Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Required for response to NTN3 and activation of NFATC3.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MHPDLGPLWTLLYVLVILCSSVSSDLAPYFISEPLSAVQKLGRPVVLHCSAKPVTARISWLHNGKRLDRNTEQIKIHRGTLTILSLNPSLSGCYQCVANNSVGAVVSGPATVSAAALGDFDSSTMHVITAEEKNTGFIGCRVPESNPKAEVRYKIRGKWLKHSTGNYIILPSGNLQVLNVSSKDKGSYKCAAYNPVTSELKVEPTGRKLLVSRPSSNGFHILHPALSQALAVLPHSPVTLECVVSGVPASQVYWLKDGQDAVAGSNWRRLYSHLATASIDPADSGNYSCVVGNKSGDVKHVTYMVNVLEHASISKGLHDQKVSLGATVHFTCDVHGNPAPNRTWFHNAQPIHPSSRHLTEGNVLKITRVVMEDSGLYQCVADNGIGFMQSTGRLQIEQDSGWKPVIVTAPANIEVMDGDFVTLSCNATGVPVPVIHWYGRHGLITSHPSQVLRSKPRKSHLFRPGDLDLEPVYLIMSQAGSSSLSIQAVTLEHAGKYTCEATNKHGSTQSEAFLTVVPFETNTKAESVTPSEASQNDERDPQDGSESSLLNLFPVKVHPSGVELPAERNASVPDAPNILSPPQTHMPDTYNLVWRAGRDGGMPINAYFVKYRKLDDGSGAVGSWHTVRVPGSENELHLTELEPSSLYEVLMVARSAVGEGQPAMLTFRTSKEKMASSKNTQASFPPVGVPKRPVTAEASNSNFGVVLTDSSRHSGVPEAPDRPTISMASETSVYVTWIPRANGGSPITAFKVEYKRMRTSDWLVAAEDIPPSKLSVEVRSLEPGSIYKFRVIAINHYGESFRSSASRPYQVAGFPNRFSNRPITGPHIAYTEAVSDTQIMLKWTYVPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHTIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASDYPVKELSTPPSSSGNAGNVGPATSPARSSDMLYLIVGCVLGVMVLILMVFIALCLWKSRQQSTIQKYDPPGYLYQGSEINGQMVEYTTLSGAARINGSVHGGFLSNGCSHLHHKGPSGVNGTLSGNINGGLYSAHTNSLTRACVEFEHPHHLVNSGGVYTAVPQMDPLECINCRNCRNNNRCFTKTNSPLPVVPVVASYPQGGLEMKPLNAMKVPVCPASTVPDHGQLPDDCVKDSVAPIPTQHTCCQDNISDINSDSTEDTAEFSRGDSSGHSEAEDKVFSWNPLILSPVLEDCGEKTARSPPGPPLDGLSVVLQQAQET
The following text describes a protein:
Function:
Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG (By similarity). May serve as a negative regulator of cellulose synthesis (as has been suggested for S.typhimurium); overexpression inhibits cell aggregation in strains able to produce adhesive curli fimbriae. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSEVLLPLIGLPCSVAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPLLRLTIDRALIKGSPVLIQWTPAAGSSNAGVMEMINIDLLTAMLLEPQLPQISSASLTVDKRHLLYGNGLVDSLPQPEDNENYQVSSQRFPFTINVNGPGATALAWHYLPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVDYRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMPLR
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MRILVLGAGGVGGFFGGRLVEKGEDVTFLVRSKRKKQLEERGLVIRSVNGDFSFRPKLITKEERTSPFDVILFSTKAYHLNEAIQDLKPFVGENTVIIPLLNGIAHLSLLQKEFGEEKVIGGLCFIETTLNDQGEIVQTSAANRLVFGEIKSQNSERVKHISKAFAGTKSSFVLSENITQDMWHKYLFITVMSGVTTLMRAPIGPIRESEGGRDFIRNVFEESVQIMRVLGAPVKANIAQEHMKTIDKISYDMKSSMQRDMEKGSFIEGKHLQGYLLDVAEQFSIAAPLLGTIYQNLKVYEEMTFNRSVIELDV
The following text describes a protein:
Function:
Essential for the anterograde spread of the infection throughout the host nervous system. Together with the gE/gI heterodimer, US9 is involved in the sorting and transport of viral structural components toward axon tips.
Subcellular Localization:
Virion membrane; Single-pass type II membrane protein. Host Golgi apparatus membrane; Single-pass type II membrane protein. Host smooth endoplasmic reticulum membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN), maybe through an interaction with PACS-1 sorting protein (Potential).
Sequence:
MTSRLSDPNSSARSDMSVPLYPTASPVSVEAYYSESEDEAANDFLVRMGRQQSVLRRRRRRTRCVGMVIACLLVAVLSGGFGALLMWLLR
The following text describes a protein:
Function:
Component of the CBC complex, which binds co-transcriptionally to the cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation. Together with NPL3, the CBC complex is required for export of mRNAs out of the nucleus. The CBC complex is also involved in nuclear mRNA degradation, probably by directing the mRNAs to the sites of degradation. Affects replication of the positive-strand RNA virus BMV.
Miscellaneous:
MISCELLANEOUS: In contrast to metazoans, where the CBC complex is involved in the nuclear export of capped U snRNAs, it is believed that in yeast, U snRNAs are not exported from the nucleus and U snRNPs are assembled in the nucleus from RNAs and imported proteins; MISCELLANEOUS: Present with 6200 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm, perinuclear region. Note=Predominantly nuclear, is able to exit the nucleus in an RNA-dependent manner.
Sequence:
MSLEEFDEVKYDHSTKRLDTPSRYLLRKARRNPNGLQELRESMKSSTIYVGNLSFYTSEEQIYELFSKCGTIKRIIMGLDRFKFTPCGFCFIIYSCPDEALNALKYLSDTKLDEKTITIDLDPGFEDGRQFGRGKSGGQVSDELRFDFDASRGGFAIPFAERVGVPHSRFDNSSSQSNTNNYIPPPDAMGTFRPGFDEEREDDNYVPQ
The following text describes a protein:
Function:
RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNVFDEVINATVVNNSVTGHFTTTLREELIITRTNLLSVLHKDNEGRLVLAYEWKLSGRVHGLSLVPHKSGLGRLAVLTGRGRVSIVRFDAENQTLETESLHYYDAKFEELSALTVGAAPRLEQEPAARCLLVHNGDCLAVLPLRGHEEEGEEAEEEEEHPAKRARTDADGRLVGASTVMPASHLHSDIKNVKDMRFLRGLNKSAVGVLYQPQLSWCGNEKLTRQTMKFIILSLDLDDEKSTVINMLQGLPNTLHTIIPLSNGCVLAGVNELLYVDNTGALQGAISLNAFSNSGLNTRIQDNSKLQAFFEQPLCYFATQSNGRDILLLMDEKARMYNVIIEAEGRLLTTFNCVQLPIVNEIFKRNMMPTSICGNMNLETGSLFIGFQSGDAMHVRLNNLKSSLEHKGTVSETLETDEDYMELYGNNAEKEKKNLETESPFDIECLDRLLNIGPVTSLAVGKASSIEHTVAKLANPNKDELSIVATSGNGTGSHLTILENTIVPTVQQALKFISVTQIWNLKIKGKDKYLVTTDSSQTRSDIYSIDRDFKPFKAADFRKNDTTVSTAVTGGGKRIVQVTSKGVHLFDINFKRMMTMNFDFEVVHVCIKDPFLLLTNSKGDIKIYELEPKHKKKFVKTVLPDALKEIIITFGVILESNMCNKYINGLEKSEEPQLLFTFVTADNQIVFFTKDHNDRIFQLNGIDDFRQKLFISTYQLPEDINPDPSIKQVIISRLGHKHKQEYLTILTFGGEVYLYRKCIDNPDRFIKCDHELLITGAPENAYPKGVQGVERVAHYIEDYNGYSVIFITGTVPYIIIKEDNSVPRIFPFANITLVSMTRWGENSVMCVDDVKNARIMTLNLDRDRYYGNKMSLAKIYLEDPLEDFQTLNNITYHERTQTFIVSYAKSIDYVALSEEDEPLVGYNPDKIHAMGFQSGIILLSPKSWEIIDKIEYGKNSLINDMRTMMIQLNSNTKRRREYLVVGNTYVRDEDIGGTGSFYLYDITEVVPEPGKPDTNYKFKDIFQEDIRGTVSTVCEISGRFMISQSSKAMVRDIQEDNSVVPVAFLDMPVFITDAKSFGNLMIIGDSMQGFSFLGFDAEPYRMLTLGKSVSKLETMCVEFLVNNGDVYFLVTDRNNLMHVLKYAPDEPNSLSGQRLVHCTSFNLHSTNTCMRLIKKNDEFGKVSRGFGIYMPSFQCIGSQADGTIFKVVPLSEASYRSLYLIQQQLIDKEVQLCGLNPRMERLENPFYQMGHILRPMLDFTVLKRFATLSIPTRMTMASKAGRQAHAEIWRDLIDIEYSLTSLNKIT
The following text describes a protein:
Function:
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.
Subcellular Localization:
Cell junction, desmosome. Cell membrane. Cytoplasm, cytoskeleton.
Sequence:
MGWAARPPSEAAGVSATPLALAHPLSSARSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVSDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVISLRGKHKQIYNLVVKEVDPQVNWAALVDEKLDKLSGQGFGTDLPLVDHQVEQHNIFHNEVKAIGPHLAKDGGKENSELQAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRVQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHRDMKDAQELLHKVDLDLNQKYGPDFKDKYQIELLLRELDDQEKALDKYEHVVRGLEKRGQQVVPLKYRRETPLKPIPVEALCDFEGDQGLISRGYSYTLQSNNGDSWDLTDSSGNKLTAPAVCFVIPPTDPEALALVDSLGSQYRSVRQKAARSKSALQQRHEVLKAENPGDPSDLQGRHLLAGLDKVARDLERQEKAVTGILRPPLEQGRAVQDSAERAKDLKNITNELRRIEPEKVRSTAECEEFVQALPGSSSTSLLKTRVEDTNRKYERLVQLLDLAQEKVDMANRLEQSLQRGWEALATYENQLTQDDTVPESGHALDSKRQELEVLASKLQTQKSLLAEVEQNLQAAKQCSSSLASRFQEHCPDLERQEVEVHKLGQRSDNVCQQVELRAQSLQSARAAYEDYRSGYDHMLQFLSHIPSYEPQETDSLSQMETKLKNQKNLLDEIARREEEVHQVCTHSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPAAKVREEEAALVAKFTEVNAINRQRLQNLEFALSLLRQQPEVGASHETLQGSTPGSTVEETWKVQKELDEETERRQQLEKEVQSAQEEIRTLQHRSPQEAVIKKEVLKKVPDPVLEESFQQMQRTLVEEQHKNQLLQEELEALRLRLHTLEQETRDGGQEYVVKEVLRIEPDRAQADEVLKLREELEELRRQKGTREAEAALLQQRIAALAEEKNQAQEKVTKKEVVKLQNDPQLEAEYRRLQEDQQREGKLREEHEEEVSFLQDKLKRLEKERAMAEGKITVKEVLKLEKDVATEREVGDLKRQYEDEEAKARANQREKTELLRKIWALEEENARVLVQEKVREIVRPDPEAEREVANLRLELVEQERKYRGAEEQLKSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDVEIYQLKQEIQSLKDTKPQVQTKEVVQEILQFQEDPQTKEEVQSLRARLSEEQKKQVDLERERASQEEKIKQKEEELSHVKEKVVQQEVVRYEEEPGLRAEVNAFTESIDAELRQIDTLRGELRRLQRRRAELERQLEELERERQARREAELEVQRLKQRLAELEEEGEAREKVTLKQKVVLQQDPQQAREHALLKVQLEEERHRRQVLESELETLRKKLVNLEKMEVKEKVVFSESVQVEKGDTEQEIQKLKSSLEEESRSKRELDAEVSRLEAKLSELEFCNSKSSKELDFLREENHRLQLERQSLQLETRRLQSEIEMAATETRDLRNVTAVDSGTNLNSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIDPDTGRELSPEEAHRVGLIDWNMFVKLRSQECDWEEISVKGPSGESSVIHDRKSGRKFSIEEALQKGRLTPAQYDRYVNKDMSIQELAVLVSGQK
The following text describes a protein:
Function:
Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Involved in the regulation of cellulose production.
Sequence:
MPVSEYNHILVAVSFAVAIFASYTALNMAGRVAGSARSNARIWLMGGGFALGVGIWAMHFVGMLAMDHAMNMRFDPFLTGLSMLIAIGSSLFALWLVSAEKLRLRRLLPGALVMGLGISAMHYTGMAALQFASIIVWNSAWVALSIIIALLASCGALWLTFRLRHEGTDVALRRAGAAVLMGIAIAGMHYAGMKAAHFPQNWPMEHRGVDSNWLAVLVSVVALTILGITLLVSLFDARLQARTALLASSLAQANQELAQLALHDTLTRLPNRVLLEDRLEQAISKANRENTSFALLFMDLDGFKTVNDAYGHDIGDKLLVAVTHRLNQPLSGQFTLARIGGDEFVLLAEVSAPDEAASLASALVHSIDAPFTIDPYELVVTLSVGIALYPLDGKNERELMFNADAAMYHTKHTGRNGYHFFQPSMNMLAQTQLQLMNDLWLALERQELRLVYQPKFQAPAGPIVGFEALLRWYHPKQGVLNPDQFLPLAEKTGLIVTIGSWVIDEACRQLREWHLQGYDLWSVAVNLSALQFEQPGLVDTITRSLARHSIRPDLLILEITETTAMNKPEQSVAILTRLTEMGVKASIDDFGTGYSSLLYLKRLPACELKIDRAFVHELSEAGDGATIVAAIVALAKALNLQIVAEGVENETQQQFLTQLGCHTLQGFLLGKPRTAEEIARDIRDPANIFTRSIYNINSK
The following text describes a protein:
Function:
Trypsin-like serine endopeptidase involved in the processing of glyoxysomal higher molecular weight precursor. The dimeric form carries out the specific cleavages needed to remove PTS2-containing presequences, whereas the monomeric form degrades the removed presequences and misfolded proteins (Probable). Not required for degradation of glyoxylate cycle enzymes during seedling development.
Subcellular Localization:
Peroxisome.
Sequence:
MDVSKVVSFSRNFAVLVKVEGPDPKGLKMRKHAFHQYHSGNATLSASGILLPRDIFLSGEVAAKVLFEAGQDMALVLTVASVVEPFLTLGHRTSSSISQDPVKLIPGAMIEIMVEGQLKSEKEAPFWVPAQLLSLVDVPVSSAALQSLIEASSGSKDSGWDIGWSLVSAANGSQPSINIEHYSKPLMQLDEPHNANFMAKSATRMAILGVPLSLLGQPSMNFASSSSKGDTLVALGSPFGILSPVNFFNSVSTGSIANSYPSGSLKKSLMIADVRCLPGMEGAPVFAKNGHLIGILIRPLRQKNSGVEIQLVVPWGAITTACSHLLLEEPSVEGKASQWGSEVLSVKSDASIPAQVAIEKAMESVCLITVNDGVWASGIILNEHGLILTNAHLLEPWRYGKGGVYGEGFKPYVLGAEEFSSTGSKFWEQKSQTLPRKAPRNHYSSVGENIREYKHNFLQTGHRDIRVRLCHLDSWTWCPANVVYICKEQLDIALLQLEYVPGKLQPITANFSSPPLGTTAHVVGHGLFGPRCGLSPSICSGVVAKVVHAKRRLNTQSISQEVAEFPAMLETTAAVHPGGSGGAVLNSSGHMIGLVTSNARHGAGTVIPHLNFSIPCAVLAPIFKFAEDMQNTTILQTLDQPSEELSSIWALMPSLSPKTEQSLPNLPKLLKDGNNKQTKGSQFAKFIAETQDMFVKPTKLSRDVIPSKL