lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probably involved in signal transduction, in the nervous system. Required for the spatial learning process. May also be involved in neurite outgrowth (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Cell projection, dendrite. Postsynapse.
Sequence:
MPNTTEEQSDEVNNLALEKCLKVLQEAQTDNEQFAALLLVTKCAQAQEINNETRRRIFDAVGFTFPNRLLFSNSVPEGCPQNLFKSLGITLLACFSTDPVLAVHPQVVNKIPIFNETINISCQSGNKEVVSMVEDAYQCLLGILASPQGPKNLLSHGSIPYLCQAYMNRNHFWEKALQILTSLLTVLPPKCWKKSCTDLQLLLTRLSEEFGKEEGEWKFQLADLLPIFLPPSPILLETSWGKQCLKQLCKGLLKILSNKLSISQRDPALKLAACLANSYGSSWIMAENKVVRSRFLALIVNLACVEVRMALEEPEPLTSRQSVITACYALVEMGILACTKEEKHPVLGKEQKLQLIGVMQEACAAIIYYLQQVGWEKQEDPFLLASVRLLGAWLAEETACLKLEVIQLLPFLVHYMRTCHQRSVICSKLPKEVSQVALLSNSWGNIWPGDAIRFLLPALCHLSAEEVPRKVLISEGVPALLCDYFQLQWDVLFAEDEPEGLQSAAELSLQTCCGVFLNLVVTEPTFVGQESCFVSLMKLLMQSLPTLLTKEGHLVLVANFSTLGLMMSRLLAENSVLHESNAEEFFKAAIHFLSHSHVPSCQTDAGKPVITLSESYSEAWEEISELWFLGVQAFSSCVHLLPWLSALVLRSSWLQDTLCLLDNVSPKSVDSDLVTALQGMLTELAQSSSCCRDVIREKGGAEKANLYGMAALEQCLAELS
The following text describes a protein:
Function:
Participates in sensory organ patterning by antagonizing the neurogenic activity of the Achaete-scute complex (AS-C). It lacks a basic DNA-binding domain but is able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. May sequester proneural proteins in complexes inefficient for DNA interaction. EMC also affects vein differentiation. Inhibits the activity of AS-C proteins by forming an non-DNA binding heterodimer.
Subcellular Localization:
Nucleus.
Sequence:
MKSLTAVCQTGASGMPALNASGRIQRHPTHRGDGENAEMKMYLSKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQTELETHPEMGNFDAAAALTAVNGLHEDEDSDMEDADAEAEAEVDPDILAQRLNAEQPAKVSSPAARLPLTDRQTPNTLVAPAHPQQHQQQQQLQLQQQQLQSQQQLSNSLATPQNAEKDSRQS
The following text describes a protein:
Function:
Dioxygenase that may catalyzes DNA N(6)-methyladenine (6 mA) demethylation (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
Sequence:
MATTNYSMIFIGNLQVAVDRSSLYESSDYSSFVARECLNKDSAMKPYDIFIFEKDEHFSVEDHYTAGNSSNESNTRPSDIFLKKKLVGLNPSILQLNREKRKATLKFSGDNKDILQSTLSSSKNINLSGGLFVSREYENKYVKFGARMRCDLVNRMKDVTLAWHESVSSTSDKNVELSSVENHKIAPKADGPGNSSNESSSSPFDIFLKKKVMRLKPSFLELNREKKKAAKGFSGIVIRPGMVLLKNYLSINNQVMIVNKCRQLGLGEGGFYQPGFQDGGLLHLKMMCLGKNWDCQTRRYGEIRPIDGSVPPRIPVEFSQLVEKAIKESKSLVATNSNETKGGDEIPLLLPDICVVNFYTSTGKLGLHQVSVYDKTSFDFLKYKGGYLNTDKGESKKSLRKGLPIVSFSIGDSAEFLYGDQKDVDKADTLILESGDVLIFGERSRNVFHGVRSIRKILPPRLFFRKQIFNQVV
The following text describes a protein:
Function:
Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.
Sequence:
MGSDFIFKVTVSIRREDDGSPVFFKIDGGRFKTSERTIKLQADVQYRLDIDIKPSLYPKSTSLGTTSLQLKEQSRDPHSVRYTTVWSTAGTSVSKKGSRQDVPFVMEFDGLGMLKVCLQCKFYKASDSDHCSWGDSFKQMELNCTLTEERTFIKVYNQQFK
The following text describes a protein:
Function:
Promotes cellular proliferation and expansion. Induces outward H(+) fluxes in roots.
Subcellular Localization:
Secreted.
Sequence:
MTFVVRLLVCLLLTLTITSSLARNPVSVSGGFENSGFQRSLLMVNVEDYGDPSANPKHDPGVPPSATGQRVVGRG
The following text describes a protein:
Function:
MKK9-MPK3/MPK6 module phosphorylates and activates EIN3, leading to the promotion of EIN3-mediated transcription in ethylene signaling. Autophosphorylates and also phosphorylates MPK3 and MPK6. Plays an important role in ethylene and camalexin biosynthesis and in salt stress response. MKK9-MPK6 module positively regulates leaf senescence.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Translocated into the nucleus by ACC treatment.
Sequence:
MALVRERRQLNLRLPLPPISDRRFSTSSSSATTTTVAGCNGISACDLEKLNVLGCGNGGIVYKVRHKTTSEIYALKTVNGDMDPIFTRQLMREMEILRRTDSPYVVKCHGIFEKPVVGEVSILMEYMDGGTLESLRGGVTEQKLAGFAKQILKGLSYLHALKIVHRDIKPANLLLNSKNEVKIADFGVSKILVRSLDSCNSYVGTCAYMSPERFDSESSGGSSDIYAGDIWSFGLMMLELLVGHFPLLPPGQRPDWATLMCAVCFGEPPRAPEGCSEEFRSFVECCLRKDSSKRWTAPQLLAHPFLREDL
The following text describes a protein:
Function:
Catalyzes the formation of thebaine from (7S)-salutaridinol 7-O-acetate at the expense of labile hydroxylated by-products, which are preferentially produced by spontaneous allylic elimination. No visible activity toward (7S)-salutaridinol (at pH 7).
Sequence:
MAPLGVSGLVGKLSTELEVDCDAEKYYNMYKHGEDVKKAVPHLCVDVKIISGDPTSSGCIKEWNVNIDGKTIRSVEETTHDDETKTLRHRVFEGDVMKDFKKFDTIMVVNPKPDGNGCVVTRSIEYEKTNENSPTPFDYLQFGHQAIEDMNKYLRDSESN
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing by regulating the release and transfer of U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complexes from their assembly site in Cajal bodies to nuclear speckles, thereby contributing to the assembly of the pre-catalytic spliceosome on target pre-mRNAs. May also participate in recycling of snRNPs back to Cajal bodies during splicing. Plays a role in regulating MAGI2-mediated endocytosis. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. Required for normal hearing.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, cilium. Nucleus speckle. Nucleus, Cajal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Photoreceptor inner segment. Note=Detected at the tip of cochlear hair cell stereocilia. Recruited to the cell membrane via interaction with CDH23 or PCDH15 (By similarity). In photoreceptor cilia, detected predominantly at the cilium base (By similarity). Expressed in the pericentriolar region of the centrosome (By similarity).
Sequence:
MNDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNPKLVGKLKDKAFREAERRIRECAKLQRRHHERMERRYRRELAERSDTLSFSSLTSSTLSRRLQHLALGSHLPYSQATLHGTARGKTKMQKKLERRKQGGEGTFKVSEDGRKSARSLSGLQLGSDVMFVRQGTYANPKEWGRAPLRDMFLSDEDSVSRATLAAEPAHSEVSTDSGHDSLFTRPGLGTMVFRRNYLSSGLHGLGREDGGLDGVGAPRGRLQSSPSLDDDSLGSANSLQDRSCGEELPWDELDLGLDEDLEPETSPLETFLASLHMEDFAALLRQEKIDLEALMLCSDLDLRSISVPLGPRKKILGAVRRRRQAMERPPALEDTEL
The following text describes a protein:
Function:
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Sequence:
MPKLEQFEIKKYWQIFSGLSPSDNKVTHDQVAPILHNSKLEAGVLGKIWFLSDIDGDGNLDFEEFVICMRLIFDMVNQNITAVPDELPDWLVPGSKVELVRQRASQGGVAAASAAPASAGEAPEMEWYMSPEDRALYERLYQKCQTATDGSVGYQGVKPVVTEHFQKITQPELEQVWALVNPKGFAAIDRDPVMYLFHLLRQRSDVGAKIPAGVPASLGETFAKERVTTDIANEGQGAIRKSELHIASASRSNSARPKNENSDYSATAGTDWEVVQLQRELAALDSQLSDLKQQQESAPPTRAEVLREQFEGLLKFKQAQLSTSTNSSPAMNVLSLTEDIDSLEEQVTVLQHYLSTRSETLQQLQWEIQSLK
The following text describes a protein:
Function:
Plays a role in skin pigmentation by antagonizing the action of melanotropin alpha. Induces melanin concentration within the melanophores. May participate in the control of the hypothalamo-pituitary adrenal gland axis by inhibiting the release of ACTH.
Sequence:
MKLSAGTVLITVALLSECYFKTAAIPMTKSEEIEPDLQSFSESLEENSLRSTPGGSRIIVVADSNLLRTLTSLNRGVPHLNAPESLLSTERREVGSDLSPNFAIIRRDTMRCMVGRVYRPCWEV
The following text describes a protein:
Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MACPVIFPDARNFHLFTPDSLAMIEKLIQAEKSKKKTPNPAVLEAPLRPQLDLKVSRKLPKIYGDIPPEVVGQPLEDLDPFYFNHKTFMVLNKKRTIYRFSAKSALFVLGPFNPIRRLAIAISVHSYPFINIQWWEHSTTIKARPSSSLPLFKYVFTAIYVFEALIKILARGLVLDEFTYLRDPWNWLDSTVIMLAFLSCKIEKLDSVSALRTFRVLRALKAISIISGLKVIVGALLRSVKKLVDVMILTIFCLSIFALVAQQLFMGSLRYRCIRKTCLNHEYERCSEKKSEGSSEARLCGTWMGNRSCCPDFVCCKTKLSPDYGFTNFDHFGWAFLSMFRVMTQDSWERLYQQTLRVAGPFAVVFFVVIIFLGSFYLINLTLAVVTMSYEEQNKNVAAETEAKEKMFKEALQLLKQEQETLVAMGIDRSSLNSLETSSISCQKRSLFGNKRRKSFLVANSGQVPGPPSDSDESVQTKQQILSQTKRLSQNLSLDYWDEHGDTFQRQRALSAVSIVTITMQEYEKSQQKCLPCQNNFASKYLIWESSPRWLRIKRVVELVIMDPFADLAITICIILNTIFMSMEHYGQGKDFDKMLCIGNYVFTGIFIAEMCLKIIALDPYYYFLRPWNIFDSIIVILSIVEIIISDVLKSNLSILRSLRLLRVFKLAKSWPTLNTLIKIIGHSVGALGNLTLVLAIIVFIFSVVGVQLFGNSFNGTLPQNGSSQVPKCRRWHMGDFFHSFLVVFRILCGEWIDNMWECMQNSSHVLCILVFLLILVIGNLVVLNLFIALLLNSFSSEEKEGNGPGEMRKTKLQLAFDRFRRAFYYVKHAIGHFCSRSFRKQRSRKLKDVSKKCKVQDKDIIPLESGINQEQRNQEKICSQDQDSSFGFTGLGSLQENLNTRYAPFIKAPLAEEEEDQEFMVEDELQNFMETEFYKQAEKECASPGATSGDIDVFFEDGPELAAPKLRESFDVTSYLSDCSTIDLKDLVLLVPEMLPPKGPERCLPKGCNKCFPCFALNVRKSPGIIWLRLRITCYRIVKHDWFESFIIFMILLSSGALIFEDCSLQSKPKIKELLNFTDRVFTYIFTLEMFLKWVAFGFRKYFTNAWCCLDFLIVNVSLTSTFSCSPKSFNVKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAIMNVLLVCLIFWLIFCMLGVNLFSGKFRKCINQTKNDELVNHTTISNMSMCNSTENPHVCWINTKVNFDHVGIGYLALLQVATFKGWMEIMYAAVDSRKVSEQPYFEANLYAYLYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKISGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQAFVFDVVTNQAFDIFIITLICLNMVTMMAETDSPEGPNKQKENLLEYLNRAFVVIFTVECLLKIFALRQFYFANGWNLFDCVVVVLSIVSNMVALLEKNKAIPFPPVLFRVIRLARIGRILRLVRAAKGIRTLLFALMMSLPSLFNIGLLLFLVISMLCLFQITTSAGWDALLSPMLSSKSASCRSDDSPCIPGSSSVMAIAFFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLSEDDFDIFYETWEKFDPEATQFIEYSVLSDFADALPDPLRVPKPNRNQLLMMDLPMVSGNRLHCMDILFAFTTRVLGDSEGIDCLKSQMEEKFMEANPNKKLYEPIMTTTKRVEEERCAAVIQKAYRHYLKKNSARKAVTSSPHQMVCNGAIDTLEVPDGKVHFD
The following text describes a protein:
Function:
Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol.
Sequence:
MEEPPVREEEEEEGEGDEERDEVGPEGALGKSPFQLTAEDVYDISYLLGRELMALGSDPRVTQLQFKVVRVLEMLEALVNEGSLALEELKMERDHLRKEVEGLRRQSPPASGEVNLGPNKMVVDLTDPNRPRFTLQELRDVLQERNKLKSQLLVVQEELQCYKSGLIPPREGPGGRREKDAVVTRANNAGRNKEEKRIIKKLFFFRSGKQT
The following text describes a protein:
Function:
Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May be acting by stabilizing endothelial cell junctions.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: May be due to an intron retention.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction.
Sequence:
MATPRAPRWPPPSLLLLLLLPLLLLPPAAPGARGSLPSPAHRTLLPVAGPLSPPGAGHTAPGPGVATRRGRSGRVPRGVSAAAARNRWLESNNPEPHIGCSPSYQSQEDHSGSRKGVTAQNARMSHSSSEGPENPPLLPETSAEWSNMASSHRADIAGLRRGPSPEITTAPTAHSSLLSLESLPESPSSSRSQRRITPSQTESGTSLGFLERTRELPEEGTVHTQVAGTWVSRQASHPALEPGEPTVLSQKRNSSGQEHSGPPFSWSQSHPPPSDHPSSSGSIKNGNNFTALQNPSVTQTKSMLITDTYTNGVPRTLRSLPVGVDPADETEGFPEHSRLGITSMSVRSSPSVKDSRTNSGLTEHLGDGEGTELSTENGYGLPSIHWQSDAPSFGGRQLASSSEAGDGRAMPLTEAVFRSDPSIGGGESTGRWILTKKKTSTDAAESSALHPEAGGAGGLTQSSHAAQQPRGGGEDSGMGGRSYAESSSSSSSTSSSESLDSSAPLREHSLTGLSYTREHGSDAGQRTSSDHTDHGYVPSTFTKGERTLLSITDNTSYSEASESSTSSVKISDSPSQAQPKQSSMSSDDDEPAQSSTESPVLHTSNLPTYTSTVNMPNTLVLDTGTKPVEDPSDSRVPSTQPSPSQPQPFSSALPSTRSPGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTLVPHRPREPRVTSVQMSTAISAIALIPSNQTANPKNQSTPQQEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPALTGFSTGPALPATSTSLAQMSPALTSAMPQTTHSPVTSPSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAITTEGNREHTDPTTQPIPLTTSTTSAGERTTELGRAEESSPSHFLTPSSPQTTDVSTAEMLTSRYITFAAQSTSQSPTALPPLTPVNSCTVNPCLHDGKCIVDLTGRGYRCVCPPAWQGENCSVDVNECLSSPCPPLATCNNTQGSFTCRCPVGYQLEKGICNLVRTFVTEFKLKKTFLNTTAENHSNTQELENEIAQTLNVCFSTLPGYIRTTAHVSREPSTVFISLKTTFALASNVTLFDLADRIQKYVNSCRSSAEVCQLLGSQRRVFRAGSLCKRKSPECDKETSICTDLDGVALCQCKSGYFQFNKMDHSCRACEDGYRLENETCMSCPFGLGGLNCGNPYQLITVVIAAAGGGLLLILGVALIVTCCRKSKNDISKLIFKSGDFQMSPYTDVPKNPRSQEWGREAIEMHENGSTKNLLQMTDVYYSPTNVRNPELERNGLYPAYTGLPGSRHSCIFPGQYNPSFISDESRRRDYF
The following text describes a protein:
Function:
Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). Involved in repair of UV light, and probably oxidative damage. The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5' to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. May mediate the induction of a DNA-damage sensitive cell-cycle checkpoint during the G2 phase.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Inactive; MISCELLANEOUS: [Isoform 3]: Inactive.
Subcellular Localization:
Nucleus.
Sequence:
MALKYHQQIISDLLEDSNGGLLILSSGLSLAKLIASLLILHSPSQGTLLLLLSPAAQSLKSRIIHYISSLDSPTPTEITADLPANQRYSLYTSGSPFFITPRILIVDLLTQRIPVSSLAGIFILNAHSISETSTEAFIIRIVKSLNSSAYIRAFSDRPQAMVSGFAKTERTMRALFLRKIHLWPRFQLDVSQELEREPPEVVDIRVSMSNYMVGIQKAIIEVMDACLKEMKKTNKVDVDDLTVESGLFKSFDEIVRRQLDPIWHTLGKRTKQLVSDLKTLRKLLDYLVRYDAVSFLKFLDTLRVSESYRSVWLFAESSYKIFDFAKKRVYRLVKASDVKSKEHVKNKSGKKRNSKGETDSVEAVGGETATNVATGVVVEEVLEEAPKWKVLREILEETQEERLKQAFSEEDNSDNNGIVLVACKDERSCMQLEDCITNNPQKVMREEWEMYLLSKIELRSMQTPQKKKQKTPKGFGILDGVVPVTTIQNSEGSSVGRQEHEALMAAASSIRKLGKTTDMASGNNNPEPHVDKASCTKGKAKKDPTSLRRSLRSCNKKTTNSKPEILPGPENEEKANEASTSAPQEANAVRPSGAKKLPPVHFYALESDQPILDILKPSVIIVYHPDMGFVRELEVYKAENPLRKLKVYFIFYDESTEVQKFEASIRRENEAFESLIRQKSSMIIPVDQDGLCMGSNSSTEFPASSTQNSLTRKAGGRKELEKETQVIVDMREFMSSLPNVLHQKGMKIIPVTLEVGDYILSPSICVERKSIQDLFQSFTSGRLFHQVEMMSRYYRIPVLLIEFSQDKSFSFQSSSDISDDVTPYNIISKLSLLVLHFPRLRLLWSRSLHATAEIFTTLKSNQDEPDETRAIRVGVPSEEGIIENDIRAENYNTSAVEFLRRLPGVSDANYRSIMEKCKSLAELASLPVETLAELMGGHKVAKSLREFLDAKYPTLL
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSSYVSVSGLSKVGEDDALQRLLSSREGSGNGSNALLEAMRKIQAENVFDAENVTFTPAAPPAPVAKAASKKESAASHASVEKPKANAVSLREPKKTSSGMSPSPTVQLAASAVQASSFRATNPTDIDSLPALVELVHPKLLRPLTDSMKIEHLTRIQKLCWAAMLDSDSDVLVRSETGSGKTLAYALPTLHRLLVECDKTPISRDVGTLIIIMCPTRELVLQVTETVTTLVRCAQFITVGGIHGGENRHKEKARLRKGLPILVTTPGRLLDHLKTTASFTVAHAQTVIMDEADRLLDMGFEKALREIMELLERKCHHASDLKRVLVSATITDGVERLSHFALRRNIARIGETQDTFSVPTTLKQHYVIVPVKHRLSVLLSFLRSQLDAGANKIIVFVSTADSTEFLYLLASRLQSPFHRRSYEGKVVTRSRGASMSAKKMVETANRHLDNGGATDEVVTFEDVSDGETEGDARIDSTAALQRAFLDANVFKLHGNMLQVDRAAVFHAFKFGTRKSRSDKSVLFCTDVAARGLDMPRIDWIVHYDPPIDPTSYVHRIGRTARIGNSGDSILFLAPDERGYAAYLTHFIHSQMQQSDGKEATEMAERKYETFLFYLTKLDPKSNHMWMQSTAALERAISRLAMQRDIERGEDAKENLYRVALFAYQSYLRAYAGMPRQTKSLFFSSTLHLGHVAQSFGIDKSPSEVQRELQAYIREDRALARDNRKGTVTNSCDGERGKSKRQRVELDHEDRYHSMLTQKQRKLTRDWAEKRRKESTKIRPLQFSEFDA
The following text describes a protein:
Function:
Cysteine protease inhibitor. Inhibits cysteine protease falcipains FP2 and FP3. Required for the invasion of host erythrocytes by merozoites. In the mosquito vector, essential for the gliding motility of hemocoel sporozoites and, therefore, for salivary gland invasion and the subsequent transmission from the mosquito to the mammalian host (By similarity). Required for the invasion of host hepatocytes (By similarity). During the liver stage, may prevent host hepatocyte cell death likely by inhibiting host cysteine proteases (By similarity).
Subcellular Localization:
Secreted. Cytoplasmic vesicle, secretory vesicle, microneme. Cytoplasmic vesicle, secretory vesicle. Parasitophorous vacuole lumen. Host cytoplasm. Note=During the asexual blood stage, localizes to the parasitophorous vacuole (PV) and to exomembrane structures beyond the limits of the PV. Localizes to punctate peripheral structures in schizonts and rings. Released after host erythrocyte rupture. Secreted by gliding sporozoites (By similarity). Localizes partially with micronemes at the apical pole of sporozoites (By similarity). Released into the host cytoplasm by sporozoites (By similarity). During the host liver stage and in late schizont and cytomere stages, localizes mainly to the PV, but is also present in the parasite cytoplasm. After completion of daughter parasite development, localizes to the host hepatocyte cytoplasm following the rupture of the PV membrane.
Domain:
The C-terminal domain is sufficient for cysteine protease inhibition.
Sequence:
MNLLVFFCFFLLSCIVHLSRCSDNNSYSFEIVNRSTWLNIAERIFKGNAPFNFTIIPYNYVNNSTEENNNKDSVLLISKNLKNSSNPVDENNHIIDSTKKNTSNNNNNNSNIVGIYESQVHEEKIKEDNTRQDNINKKENEIINNNHQIPVSNIFSENIDNNKNYIESNYKSTYNNNPELIHSTDFIGSNNNHTFNFLSRYNNSVLNNMQGNTKVPGNVPELKARIFSEEENTEVESAENNHTNSLNPNESCDQIIKLGDIINSVNEKIISINSTVNNVLCINLDSVNGNGFVWTLLGVHKKKPLIDPSNFPTKRVTQSYVSPDISVTNPVPIPKNSNTNKDDSINNKQDGSQNNTTTNHFPKPREQLVGGSSMLISKIKPHKPGKYFIVYSYYRPFDPTRDTNTRIVELNVQ
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MNGSLSRGPAPRTATITNHDRKPIPPSMFTFRKTTPAEMKQASTPKSLSLVNRGVFTNPEYLKHTVRPPIRQQAPPPVTVPPIRKEPIRQQYQLPRPILYAPATVYQEEDEDDDDGPQYALPAEHLFPHPPPEEPFQAEPTSTQYDDQFSSTSSPVSTSVSTAYTTPISTPTVNPQFSQVDTSTPSSYSNTSFTNEPVFKKAYTVSDNVPSSSTDVAHNSASGNSQEADNSNTIELPTNCKLFQYQWVVDGIPRTLLVPMPINATEQDVREMLPTTLNVDPEELARTFRADTSKAEITTLSLPGGGMPTIETADDDEQQEEYVSEFDESVDYDDEADEYSPILVNPKQYHRIVRRREMRQRLEASGRLPLSRQKYLHESRHRHALNRKRGIDGRFDNALMAGRGGEDDDDDEDDDEVSTTSHIRPIDRRLLPKLAPIAAGPGGMAPVYKCNDYTIRSVPTTSANMQNTVQMIHNGGQTTTTHQIIHHDSHNQTMMMDPNIPSTSTGIYETQMIDHQQNYMNAPMNSYDDYTHHEQYEADTLHYQDNTEVGVDLTGADGQSFTNL
The following text describes a protein:
Function:
Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Can also methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate. During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity. Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression. During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema. EWSR1 joins PRDM9 with the chromosomal axis through REC8. In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation. Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation. In addition performs automethylation. Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes in nuclei of pre-leptotene, leptotene, and early to mid-zygotene spermatocytes.
Domain:
The C2H2-type zinc fingers determines the hotspot localization through its binding to specific DNA sequences. Variations in their sequence affects affinity towards DNA-binding motif.
Sequence:
MSLSPDLPPSEEQNLEIQGSATNCYSVVIIEEQDDTFNDQPFYCEMCQQHFIDQCETHGPPSFTCDSPAALGTPQRALLTLPQGLVIGRSSISHAGLGVFNQGQTVPLGMHFGPFDGEEISEEKALDSANSWVICRGNNQYSYIDAEKDTHSNWMKFVVCSRSETEQNLVAFQQNGRILFRCCRPISPGQEFRVWYAEEYAQGLGAIWDKIWDNKCISQGSTEEQATQNCPCPFCHYSFPTLVYLHAHVKRTHPNEYAQFTQTHPLESEAHTPITEVEQCLVASDEALSTQTQPVTESPQEQISTQNGQPIHQTENSDEPDASDIYTAAGEISDEIHACVDCGRSFLRSCHLKRHQRTIHSKEKPYCCSQCKKCFSQATGLKRHQHTHQEQEKNIESPDRPSDIYPCTKCTLSFVAKINLHQHLKRHHHGEYLRLVESGSLTAETEEDHTEVCFDKQDPNYEPPSRGRKSTKNSLKGRGCPKKVAVGRPRGRPPKNKNLEVEVQKISPICTNCEQSFSDLETLKTHQCPRRDDEGDNVEHPQEASQYICGECIRAFSNLDLLKAHECIQQGEGSYCCPHCDLYFNRMCNLRRHERTIHSKEKPYCCTVCLKSFTQSSGLKRHQQSHLRRKSHRQSSALFTAAIFPCAYCPFSFTDERYLYKHIRRHHPEMSLKYLSFQEGGVLSVEKPHSCSQCCKSFSTIKGFKNHSCFKQGEKVYLCPDCGKAFSWFNSLKQHQRIHTGEKPYTCSQCGKSFVHSGQLNVHLRTHTGEKPFLCSQCGESFRQSGDLRRHEQKHSGVRPCQCPDCGKSFSRPQSLKAHQQLHVGTKLFPCTQCGKSFTRRYHLTRHHQKMHS
The following text describes a protein:
Function:
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. May be involved in the organization of actin in endothelial cells.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction, tight junction.
Domain:
The C-terminal is cytoplasmic and is important for interaction with ZO-1. Sufficient for the tight junction localization. Involved in the regulation of the permeability barrier function of the tight junction (By similarity).
Sequence:
MSVRPFESPPPYRPDEFKPNHYAPSNDMYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLVIVMCIAVFACVASTLAWDRAYGTGIFGGSMNYPYGSGFGSYGGGFGGYGYGYGYGYGGYTDPRAAKGFLLAMAAFCFIASLVIFVTSVIRSGMSRTRRYYLIVIIVSAILGIMVFIATIVYIMGVNPTAQASGSMYGSQIYTICSQFYTPGGTGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIVFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVKNVSAGTQDMPPPPSDYAERVDSPMAYSSNGKVNGKRSYPDSLYKSPPLVPEVAQEIPLTLSVDDFRQPRYSSNDNLETPSKRTPTKGKAGKAKRTDPDHYETDYTTGGESCDELEEDWLREYPPITSDQQRQLYKRNFDAGLQEYKSLLAELDEVNKELSRLDRELDDYREESEEYMAAADEYNRLKQVKGSADYKSKKNYCKQLKSKLSHIKRMVGDYDRRKT
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MEADKSGEGEKAGGKTISFRCSDGQAFHMPVAAAMLSTAIRKMFDKYPSIDHGGVIELPHQISSGIFPKVKEYCTKHAKVDDKGNPTVSTNTGAAAAASSSSTDDEEEDLKNWDKEFVNMEVKPLHDLLLVAHLLDIKGLFHITCRKVADMLKGKTSEEMRQILNIRNDFTEEEDKAIKEQNPWVFPDPE
The following text describes a protein:
Function:
High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source.
Miscellaneous:
MISCELLANEOUS: Present with 1300 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Endoplasmic reticulum.
Sequence:
MDILKRGNESDKFTKIETESTTIPNDSDRSGSLIRRMKDSFKQSNLHVIPEDLENSEQTEQEKIQWKLASQPYQKVLSQRHLTMIAIGGTLGTGLFIGLGYSLASGPAALLIGFLLVGTSMFCVVQSAAELSCQFPVSGSYATHVSRFIDESVGFTVATNYALAWLISFPSELIGCALTISYWNQTVNPAVWVAIFYVFIMVLNLFGVRGFAETEFALSIIKVIAIFIFIIIGIVLIAGGGPNSTGYIGAKYWHDPGAFAKPVFKNLCNTFVSAAFSFGGSELVLLTSTESKNISAISRAAKGTFWRIAIFYITTVVIIGCLVPYNDPRLLSGSNSEDVSASPFVIALSNTGSMGAKVSNFMNVVILVAVVSVCNSCVYASSRLIQALGASGQLPSVCSYMDRKGRPLVGIGISGAFGLLGFLVASKKEDEVFTWLFALCSISSFFTWFCICMSQIRFRMALKAQGRSNDEIAYKSILGVYGGILGCVLNALLIAGEIYVSAAPVGSPSSAEAFFEYCLSIPIMIVVYFAHRFYRRDWKHFYIKRSEIDLDTGCSVENLELFKAQKEAEEQLIASKPFYYKIYRFWC
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHSDAPTPVANELSEVSHLAEGDNASFSAGNFTVLQLPSDPSHCIDYAIPAGTLVIVDPNNPDNNRTVKLQAPAVFRPQCALGGTRAPAPRPEESFPDWSEYQKYHHNDRRDPFYGSVTPIAYTIAASTVTAWMLLIILFLSRKPSPLFQKIAVLITAVSLTVFLAQATDTLESQYNEGYQNAYELRHKIMGGWAFRILQVITCVITWLARLQVVIRLFDVPKINTRLAVVGSTLIFTNATIWACLNLIPPWSQYVRNAKSVLPVFGALCSLLLEVFYLVVVVIYSISKRKYAYSRTSIVMAAISWLAMILPMVFIVFDIAHYWIAGWSDFIRWTADAAASVVVWEWTNVIVYQERREQRQSVLGRQVYRDEILDFKGDNGGGTVGGGRTKYPSRMEEDDVPFRSSPNDHHFTSNIPTSAGEGQSFQFFKRARLPMYSRKIWKIARGESAASNNTHYEHAIIEEEEEESIERNRRTPTVQENGEEDDEETYDEENDQYSQDNHSSVHSFESSRPSQHPVPSSGGTRAVGHTHFPLPGQSEGAHTTSPAAAAAAAEPEPEPVAGPSGGAAAHGDSDDDSDNSDDSSLASFTVIQQTGFSVDNQGVPEYDADSAPPTFEPIPGFHRQDYSDAKG