lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MYRRSNSSSQLPVPNRSRSKSSVSRVSAKDDNAKRFRANSMDRTLNPPLKRSTSSSNLRRPSVTPSVSYKKSTVITPTLNSGLKRSNSNLTTPRSRSKSPYKIGSAINDKKWVSDQYAKVLRFLREHPNCPEHLPNTIKPPTINSFVAVFNLLFKEIDPRFEVNTTNYKDIVLNTLKIYQFPGNISLSLLKTVNTMHAWPQVMGILGWLVDLVTYITQTNVNSALEQDPKYQKVECVTNYVLERYQLYNNNDDQEIADQAVSQELVKVLDIDDAETKRQQEEVIKLEQLKELRLEQINEQKNKNEMLDKEITQLQEETESFYQDREQREEASRASIESLRERKEKLVTLIKMKCESVESLKVEIKNQPCAIEERNKILEHIEAMKRKIDLKKEKIKTQKNIELTCHSKLKEAKNKVENEVYRLNNSLMKLTVVKPELKLLHLDESCDFSSAEFRKKVQNLPAKIKSCETMISDEITSQKTSIAKMKTEISTLEEHILSNKQLIETLTEKEISLKNQIRSLNEHLEEMVKQRKEEEALFKEKMKKMEQSAPPLVEIKQNIEQLKKIKQEKEEEHEKHKYQALEFFTKLESDVSNYVEKMNAKRNQVLDQLATCLQQTATVQQSIIDDMLTLEEIKKS
The following text describes a protein:
Function:
Involved in methylamine metabolism. Essential for the maturation of the beta subunit of MADH, presumably via a step in the biosynthesis of tryptophan tryptophylquinone (TTQ), the cofactor of MADH.
Subcellular Localization:
Periplasm.
Sequence:
MNRILSIFTFISVLFLLSGCKEPDQKMELESFVVKNIIHPNNNPYNKDKVELGKLLYFDKRLSLKGDTNCAICHSVEIRDLEKNSLPKNKIHNSSAPSLTNVGLYKDVFMDSQANDLEEIVKERIHTAVMLKDEKTIVARLNRVQTYRELFEKSFGSPGITMDRIVKAISAFERTILSKNSKFDRYVMGEESALSPAQKRGLDVFMNKAKCFQCHKGPNFSDSEKHTTGLSGITQKVRTPSLRDVSKKNKFMHNGEFTNLEDVVNHFVNGGAKDSIQDPLLKESTITEEEKKDLVEFLKSLEGEFQLLEIPKIPKA
The following text describes a protein:
Function:
Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle. Note=Cell periphery. The polarization of EXO84 requires actin cables (By similarity).
Sequence:
MASLRRPSTAIPRGPASVQFDRGARPPLPNDNKQKRMSKVGEKIKKRLSMRYGGNESFSVPPPLPGASDFLTADPYGGLDIETPGEDLAASPFGLYGASDLKESSIQSSQPLDTQEHLVDESIGRRGAADATLEEEWNLEELSNEKVDAQAYVKKVLTGADEEEKRRFVAALMREKQANKKELQRTVFKHYAEFVAISKEISTLENDMLELKELLGQWKDLPQLMGMEDTLAPTLDRNGNLERRRTQRKSVFDLQNLYRNQLTQLWSIVEGSQKYLPVVAGRHLVFELHGVVELNPATYKPKQNVSIFLLNDVLLIAGKRRNKGGSTTSVGDEKDRDRGRMVAERCWNLIELGIVDVKDGGELVNVIKVHRGKEHCVYRTQKSDDKRALINAFRQISREANEKKRKDSEKEQERRKTMWLGDKNGNGTGNSGHPLSTIGPSMADSKDLRWIDEYGDELTMAIAIRDWEESVKLVEKGQALSKSIESNSSAHSLLVSRLEQLVPSLVSQISHDLSSSNLRKSSSARLISLLVRLDLADHARDSFLESRRELMFKRVRSIKCDGDVSIYINELAVVIFTIIRHTSDWYMNAFKENNMASGFVTWAKQQIETFADLFRRQMDAPNISESTVNECLHVTATQNRKLLRDVGLDFTFLLSSLLQPSSNPSDYPHSVFTSV
The following text describes a protein:
Function:
Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle, lowering the ATP/ADP ratio and reactive oxygen species (ROS) production. May mediate inducible proton entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress. The proton currents are most likely associated with fatty acid flipping across the inner membrane of mitochondria in a metabolic process regulated by free fatty acids and purine nucleotides.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MVGLKPSDIPPTQGVKFLSAGTAACIADLFTFPLDTAKVRLQIQGEKAAADAVKNIRYRGVFGTIATMVKTEGPKSLYNGLVAGLQRQMSFASIRIGLYDTVKQFYTAGKDNPGIGVRILAGCTTGAMAVSIAQPTDVVKVRFQAQMNLKGVERRYSGTLQAYRQIFRQEGLRGLWKGTLPNITRNALVNCTELVTYDIIKEAILNHQLMSDNLPCHFVSAFGAGFCTTVIASPVDVVKTRYMNSPPGQYKSALNCAWTMLTKEGPTAFYKGFVPSFLRLGSWNVVMFVSYEQLKRAMMMSKQSMEIAA
The following text describes a protein:
Function:
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm. TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta.
Sequence:
MFRTKRSALVRRLWRSRAPGGEDEEEGVGGGGGGGGLRGEGATDGRAYGAGGGGAGRAGCCLGKAVRGAKGHHHPHPPSSGAGAAGGAEADLKALTHSVLKKLKERQLELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPASAQPAQPPSSYSLPLLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHHLSRLCELESPPPPYSRYPMDFLKPTADCPDAVPSSDETGGTNYLAPGGLSDSQLLLEPGDRSHWCVVAYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEFMQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNSR
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Sequence:
MLSRCQLLPGRPIIHNVVIRTAQSTRRTYATSDPAPVVKNPLRRKKGGDLGTHLPKHVIPIDSYIPAYPYGDHALFKQANRGLYGDQMIHFGNNVSEKTETKTRRDWKPNVLSKGLYSVALKKKIKLRITSRVLKTMDREGGLDEYLLKDNEHRLKELGPLGWALRWTLMQKPEVIDRMRAQASALGVDQATIDAQWPTPRMLNEQRVLQAGFVRATDLVGEDEHEEAEEGDTEYDITRLKRRIRERARDEYLGILKTAHRYLARQHVNSEAEGIKLAFIRTKEHKEAFNRFRMKLGQKLDKQFSPQEIAEARVRLKLPSELSDSRVRKILSNERKPQEIEEAGSHKAWIDKVNAEEDAIKNAEEDAITMAQYAEANGGKELPESELKNHYAKMIEEAENAANNEELDHSRREFLKAAMAKADKMIRERGSGGQGAWVQSAAENYLRDLAEQAAKQSAKQAARQAAPREA
The following text describes a protein:
Function:
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
Subcellular Localization:
Cytoplasm.
Sequence:
MEKIFKVTSDSGIHARPATLLVNTASKFGSDINLEYNGKNVNLKSIMGVMSLGIQQNAEIKITANGDDAAQALAAIEETMKNEGLGE
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MVISDYARAKSLFAETDIKIFKKDVQKKMLKDESVCEGGSIAETLESILQGASKNADALFQDVLNRKDDADRTRNALNVLQRFRFLFSLPQSIERNIQQGDYEMVISDYARAKSLFAETDIKIFKKGSDNSGSDNSSPDNSSSDNSSPDNSSPDNSSPDNSSPDNSSSYYSSPDNSSSDNSSPDISVSQEVDLKIEGFRTYLKSKLLDFPSPLEEQKRVIRYLVELDVTDDPAWTCLVNQHTWLTKLLTSCRDDHQRKDAAPLLQVDAGGMLDVDALSKKAAMPVHFRSEGFKDSSSLGTQGLGGKATSMDRQHRGSVMSTPQRVKFVEELSELVTESVPDLWRLGQAYFGNMLMGEGIGSTAKQLSPSQENEVKFKSMVEDVTSLYTDLVRAAFLPSSVGLSRQPDHLGKWQSSHEGMSAWLPFCVRNVSACHSSLAQLQLPSAALDSVRSLVGDLRFLCTTEVFKEAIAEIKTLHCNELWNHENDINIGRITSLPLLFENIVMETLHTLKEIASEGDLEHTEGSQRVRDKAAQLFTEMLQAFVECFQSLAFHQDQDQDRISVSSLSDTQSTYSLDDNTPAIDERLLIVLNNCRYVRLHVLPKLVESFRRHGYTIGDPLTQSLQGEFSQLENRIVDAYIEQKGESLVGGLEPGMCAGDFKWHDCLPPNDVRNYVKEAIMNLVMVHAQVFRVSIDLLPLVLSRLTDLLANEFKRLMEKIGKSKRKFMSAGAVTAHLEARAFQEALVAYLSPGARAAFLMALEEVPPLTKDSDKKLIEALMTSFKRKMGLQLQCFQIDMDEF
The following text describes a protein:
Function:
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
Sequence:
MLPRAVAHISAAALDHNLSALAQRSGTRLLLPVKADAYGHGMELVGRLAAAHPDVWGLAVATPQEAETLARLDLGKPLLLLTPPAPEELGALADLGVRLPVSTLAEVEALPAHAQAHLKVDTGMNRLGARPADAVAVGRALAERGQLEGVYTHFATADEPDLSFALTQLVRFRSVLDALPPVLAHCANGGGVLSFGRIEGMSLARPGLAAYGYVPEHLRHVCALRPVMTVRARVNQLHTAYPGETVSYGALWRAERETGVAVVGMGYADGYPRNATGRAAVLIGGERRPVLGRICMDQMMVDVTGLDVGVGDWAELWGEGDLSVTDVARWGDTIEYEVLTGLGSRVERRVG
The following text describes a protein:
Function:
Tyrosine protein phosphatase which may function as a dosage-dependent inducer in mitotic control.
Sequence:
MGPTENQSFEIEFPNSSNTAAANSISTAINNNTTTAATITFTPANNNINNINNNNNNNNNNKFNSNFDIESNKENSINQSNINSNVNSFPLKIQTKTLNSTTTSSNNNNNNIFSIGFRPLSPRGVSPRFHSNSSSSCSSEISTPSSSTFLEDPNLIASNTISSNNSINNNNNNNNNNNNNNNNNNNDNSNNNINTNNINNNNNNTNNGENPQKKQRNSQILSKNFYSLSLHADSPKHSRSTTDLSTFLGMSDPDVMTYRSKTFCISDFHQFDIDTTTNDNKNKNNNTKSTDESSTFDGKSSNSVENNNMTIINNNNNNNNNNNNNNNNNNNNNNLNQDRPTIPTVAHSLSSNSIPHKFNSSNSLPPQMLSSSAPSLFSLLENSNNNNNNNNNNNNNNNNNNNNNNNNDNSNISINDESIVLISTPVKEYSYNRSLCLSDEEGGEDDEDDTPPTPIQLVRPTPTPINPSLSLSLSSSLNATNSTTYLHLGRSATVLLNPPLLVSSMRQHHNSPSSSPSQSIPIVQTRERSQSSLSFLSPYQQQYYPSSPELSPMVPTPLVNRIFNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGTNSNNLNNQSTSEDRDDSPNTSLDQISGSPYKTPSKLSFHSPNSSAIFNSISNSQQTGKRSRTCLDFTKFSSHLLDEDSSCFSTQTNNNNTSSTGLISPSSSPKQQNVLIENTTNTTSNSSSSSSSTTTTTTTISVTNTLAAIQQNLNSNANLNNNNNNNNNNNNNISSYFSRSNSISSQRPPRPLSMSSSFISRQSPDIHISSNSLPKPVDTSNTNNNNENENDTNKLDKINNVNSNIAKIIEQQQQRNISNSNNNNNLTQDQDQQDDQFKAKLLKQLSGRQGYNGVSSESVYELLKNPTLINAIITVVDCRYKYEYDGGHIKNAINIPPTGSRQMVLDRFFKFPTPKNQQHVIIFHCEFSSKRAPDCYSLFRELDREHNEYPNIHYPEIYLLNGGYKKFFESFQGDMCEGNYIRMDDKLYQANLKEEEEKKKKEKITIRNIKAFKNRSHSFHV
The following text describes a protein:
Function:
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
Sequence:
MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYPNVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIENHLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNVYHELSTDYLDVRDVDAPSYWYKNINYQHDLDALIQKL
The following text describes a protein:
Function:
Acts as a component of a SCF E3 ubiquitin ligase complexes.
Subcellular Localization:
Nucleus.
Sequence:
MSLSASVVVPRVLSSPAVMRQNPLKRKRDDEITVHEEDDVHEHTKPHPPSWETLCVLGPYMDPETLAVASCVSTTWLECFSSDDLWKALLTTRSSQRSSPYEIVLKNTESISCKHLVSAVETDAKRRRKDQVAEPVKISLSDLSFIIHVSTKTNKASVYKKGKDLEFGPSDKFQLEADVSNAAITAGEDDVMMTWQVMYKEKFFTIADTTRSLGTKNGWFTDKLEDKCNRKLVGDVKPSFKGEVLEKIGFSVVDSDGWGSLLLDGFLRYLQRFFLE
The following text describes a protein:
Function:
Plays a role in the protection against host NK cell cytotoxicity by interacting with and modulating the activity of the host inhibitory leukocyte Ig-like receptor 1/LILRB1, which is expressed on monocytes, dendritic cells, as well as subsets of T and NK cells. UL18 exerts an inhibitory effect on LIR-1+ NK cells, while it stimulates LIR-1- NK cell. These modulations prevent lysis of the infected cells by NK cells.
Subcellular Localization:
Host membrane; Single-pass membrane protein.
Sequence:
MMTMWCLTLFVLWMLRVVGMHVLRYGYTGIFDDTSHMTLTVVGIFDGQHFFTYHVNSSDKASSRANGTISWMANVSAAYPTYLDGERAKGDLIFNQTEQNLLELEIALGYRSQSVLTWTHECNTTENGSFVAGYEGFGWDGETLMELKDNLTLWTGPNYEISWLKQNKTYIDGKIKNISEGDTTIQRNYLKGNCTQWSVIYSGFQPPVTHPVVKGGVRNQNDNRAEAFCTSYGFFPGEINITFIHYGDKVPEDSEPQCNPLLPTLDGTFHQGCYVAIFCNQNYTCRVTHGNWTVEIPISVTSPDDSSSGEVPDHPTANKRYNTMTISSVLLALLLCALLFAFLHYFTTLKQYLRNLAFAWRYRKVRSS
The following text describes a protein:
Function:
An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E.
Subcellular Localization:
Cell inner membrane. Cell membrane; Single-pass membrane protein.
Sequence:
MDKLGQEWVSAAVDGETDVQTMAELAADTHSHNKWRNYHLIGDAMRGELPQTMAFDLSASIAAAIDLEPAIVSPQVTAPEVTTVPQQVAVNEGQSRVVPLFKQFGQYAIAATVAMFAIVGVQNFNQTADDATSPSPVLITRPLVGSASPVSLQTGPVQQNQSYTNDQMNEQRRRINTYIQDHMLQQRLNTGAVVEDNSEVIPVPVNQ
The following text describes a protein:
Function:
Transcriptional factor that targets the CArG motif 5'-C(A/T)TTAAAAAG-3' in the promoter of D14. Directly suppresses D14 expression to control the outgrowth of axillary buds.
Subcellular Localization:
Nucleus.
Sequence:
MGRGKIVIRRIDNSTSRQVTFSKRRNGLLKKAKELSILCDAEVGLVVFSSTGRLYEFSSTNMKTVIDRYTNAKEELLGGNATSEIKIWQREAASLRQQLHNLQESHKQLMGEELSGLGVRDLQGLENRLEISLRNIRMRKDNLLKSEIEELHVKGSLIHQENIELSRSLNVMSQQKLELYNKLQACEQRGATDANESSSTPYSFRIIQNANMPPSLELSQSQQREGECSKTAAPELGLHLP
The following text describes a protein:
Function:
Chaperone that binds to RNA, single- (ssDNA) and double-stranded (dsDNA) DNA, and unwinds nucleic acid duplex. Accelerates seed germination and seedling growth under cold stress, and contributes to enhancement of cold and freezing tolerance. Regulates flowering transition, and flower and seed development. Promotes seed germination under salt stress. May regulate respiratory oxygen uptake.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MSGDNGGGERRKGSVKWFDTQKGFGFITPDDGGDDLFVHQSSIRSEGFRSLAAEEAVEFEVEIDNNNRPKAIDVSGPDGAPVQGNSGGGSSGGRGGFGGGRGGGRGSGGGYGGGGGGYGGRGGGGRGGSDCYKCGEPGHMARDCSEGGGGYGGGGGGYGGGGGYGGGGGGYGGGGRGGGGGGGSCYSCGESGHFARDCTSGGR
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Nucleus.
Sequence:
MDSGVIAAYVYEKNQDSNESDDLVAVISSKIQSGEFRIVDLVANLGEFLTRDDNNVRGKALLLLSCVLERLPSDYLTAKHVYVLFQFYLNRLDDEFVLKENMRGLGAILKMNQLPIQQIPTFLEHISTQIDMPKYSQSTRHAVLTTLKIFLTVHMDSLVKAGPSFCYPKFVKLFQGEKDPRNIMLCFEMIKLLIQNLDVTPYAEEIFNISYCYFPITFRAPANDPQFPITTEQLKHSLRDVLVSTSLFSPFLLPLLFEKLKASAARVKLDTLDILYHAFCFWPIESFSNETKNYWVSVKHDIWEETDTNVKNEALKVLNKLALRMSESSALVEQNRQWLSLIIDENLQNITKDFDNKAGISFGASFAAISSNNPAVFEFSFDKVVKFLEDNCKAEESLPKKQTLLSFCSYLVDSALKVYGRRKQVKSVEISPLFLQSKNLLLVFAYASLEGVSKDQVQLRTLALRCVHKIACIRGYMNDEEVAMVARILRDIAFDKDEPLSKDAVEKIADLAKYKPTIISEVCFPTAFSQLELSANQSSEGFSHAFHVLEQISTETFLFNSLVVRTTALIEDQLRNETENSKLVDLALQTLLRTLRRKLKENSTDAYLHGKDLLSWIFKQAQSYALNEARLHVSSLLTMSRMVNELVRVFSHDDQEEFFQQVWNLYLPVHPESQRTSALKVYFDDKAKQFRPFQIESNQKLHDTLPLFCAAYTALRPTVSYIRTLDVELVSLFIKLVYNDNSNIVKMFLLRSICSAINKADSVDAFLNSPDYVSCYKNFETGTNADQSLDIVAFVIKGLVGRNYTQAIASLKQYVKILESDRFIRLLPNEILYICKDDFYLSKENHFVQKLLFKQKLYNAIMPSLMTSLQDASEQRKPAYLMALANVIGNVPNEIVMSDLSNLFPLLLQSLSLDNPAVKYYALNVILASITELPELVAEHIETLIDLLLKAACDLNNLFIVRLTALKSLGSITEQIPAPKLQPLRNRVQRELVKALDDPKRDVRAAACSARHKWFS
The following text describes a protein:
Function:
Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites.
Subcellular Localization:
Nucleus. Note=Present in a single sharp spot near the nuclear membrane, distinct from the spindle pole bodies and nucleolus. In dividing cells, the spot is exclusively present in the mother cell.
Domain:
The SHP box and the VCP-interaction motif (VIM) are important both together for binding to CDC48. The 2 SUMO interaction motifs (SIM) are each important for binding to SMT3(SUMO).
Sequence:
MKTEGIKSPSAKYHDMAGSQRIPHKNPHIQKVAVLQSKPNKEDALNLIKEIAHKVSYLMKENHFKVTNLVEFYPRDQRLLGMNVNHGSKIMLRLRCSTDEFQFLPMECIMGTMLHELTHNLFGPHDKKFYNKLDELIGRQWVIEQRGLYDTFLGNGQRLGGRANLRSNRYPMTGISTNTGIVRKRGKGVKLGSLHPEGISSIDRGNSPRELAAFAAERRYRDDRWCGETKNNKDQIISDNISSSLEVVILDDDDEVLPGDTLIEVIDLT
The following text describes a protein:
Function:
Transcription factor required for the efficient replication of minichromosomes and the transcriptional regulation of early cell cycle genes. Activates transcription of ECB-dependent genes during the G1/M phase. Genes that contain a ECB (early cell box) element in their transcription regulatory region are transcribed only during G1/M phases. Interacts with the alpha-2 repressor or with the alpha-1 activator thereby regulating the expression of mating-type-specific genes. With ARG80, ARG81 and ARG82, coordinates the expression of arginine anabolic and catabolic genes in response to arginine.
Miscellaneous:
MISCELLANEOUS: Present with 8970 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSDIEEGTPTNNGQQKERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVSETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDDEEEDEEEDGDDDDDDDDDGNDMQRQQPQQQQPQQQQQVLNAHANSLGHLNQDQVPAGALKQEVKSQLLGGANPNQNSMIQQQQHHTQNSQPQQQQQQQPQQQMSQQQMSQHPRPQQGIPHPQQSQPQQQQQQQQQLQQQQQQQQQQPLTGIHQPHQQAFANAASPYLNAEQNAAYQQYFQEPQQGQY
The following text describes a protein:
Function:
Involved in the biosynthesis of the amino sugar dTDP-L-megosamine which is found in the macrolide antibiotic and antiparasitic megalomicin A. Catalyzes the reversible transfer of the amino group from L-glutamate to the C-3 position of dTDP-3-keto-4,6-deoxyglucose to yield dTDP-3-amino-3,4,6-trideoxyglucose.
Sequence:
MTTYVWSYLLEYERERADILDAVQKVFASGSLILGQSVENFETEYARYHGIAHCVGVDNGTNAVKLALESVGVGRDDEVVTVSNTAAPTVLAIDEIGARPVFVDVRDEDYLMDTDLVEAAVTPRTKAIVPVHLYGQCVDMTALRELADRRGLKLVEDCAQAHGARRDGRLAGTMSDAAAFSFYPTKVLGAYGDGGAVVTNDDETARALRRLRYYGMEEVYYVTRTPGHNSRLDEVQAEILRRKLTRLDAYVAGRRAVAQRYVDGLADLQDSHGLELPVVTDGNEHVFYVYVVRHPRRDEIIKRLRDGYDISLNISYPWPVHTMTGFAHLGVASGSLPVTERLAGEIFSLPMYPSLPHDLQDRVIEAVREVITGL
The following text describes a protein:
Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
Sequence:
MPELPEVTTVINELKETVLNKPLDQVQVNLRKVLKNIDPQLLNKQLKNQFFTDIKRKGKYIIFLLSNGLYLVSHLRMEGKYFFEERGSKFNQKHVLVEFHFDDGSQLNYHDTRQFGTFHLYEKLEQAAQLNKLAFDPLEAGFDYRKIFQKAQNSKRKVKTFILDQTVISGIGNIYADEILFASKINPETMVDQLTIKEIEILCKNATKILAKAIVMKGTTISSFSFKKDHTGGYQNFLKVHTKKDQPCSVCNQLIVKKKINGRGSYFCLNCQKITTKVSTKLNP
The following text describes a protein:
Function:
Participates positively in the ciliary Hedgehog (Hh) signaling.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cell projection, cilium. Note=Colocalizes with EVC and IQCE at the EvC zone of primary cilia.
Sequence:
MQESQETHISNHLDEVVAAVSITHRKKFQNKLLQTALFQPPREKLHLCEEKAKSYSNSHEYKQAVHELVRCVALTRICYGDSHWKLAEAHVNLAQGYLQLKGLSLQAKQHAEKARQILANSIVPPYSENTDVFKFSIELFHTMGRALLSLQKFKEAAENLTKAERLSKELLQCGRIIKEEWIEIEARIRLSFAQVYQGQKKSKEALSHYQAALEYVEISKGETSRECVPILRELAGVEQALGLHDVSINHFLQAHLIILSRSPSQVEAADSAHIVAHAAVASGRHEHHDVAEQYFQESMAHLKDSEGMGRTKFLSIQDEFCHFLQMTGQKERATSILRESLEAKVEAFGDFSPEVAETYRLLGGADLAQGNHSGARKKLKKCLQIQTLLYGPQDKRTLATQQAMGMLSTAPKVASKPRQASKAKVAFCTSIPQDTLLGKARPGTTAD
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTLAAASHGFLSPTGVEIAFLLVGLVTLAAAVVTVTTRQLVHAALWLVVALGGLAVEYLLLTAEFIAWVQVLIYVGAVVVLILFGLMLTRAPIGRSPDADSGNRWAALTVAVASAAALVWVVVDAFRTTWIDLDGPAAGSTAVTGASLFQNWVLPFEALSVLLLAALVGAIVLSRKAKAARADEASRPGTSRTGGAR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. Activates the Hippo signaling pathway in response to cell contact inhibition and recruitment to the Crumbs complex at the cell membrane. Monoubiquitinates AMOTL2 which facilitates its interaction with and activation of LATS2. LATS2 then phosphorylates YAP1, excluding it from the nucleus and therefore ultimately represses YAP1-driven transcription of target genes.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Cell junction. Note=Translocates to the plasma membrane in response to increased cell-cell contact inhibition and subsequent interaction with the Crumbs complex.
Domain:
The WW domains mediate interaction with PPxY motif-containing proteins.
Sequence:
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLKLSLENKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE
The following text describes a protein:
Function:
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Increases the apparent affinity of the transporter for Na(+) and increases NKA activity.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Note=Detected in the basolateral membrane of collecting duct principal cells.
Sequence:
MEEITCAFLLLLAGLPALEASDPVDKDSPFYYDWESLQLGGLIFGGLLCIAGIAMALSGKCKCRRTHKPSSLPGKATPLIIPGSANTC
The following text describes a protein:
Function:
Component of the copulatory plug.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to competing acceptor splice site.
Subcellular Localization:
Secreted.
Sequence:
MKSIFFSLSLLLLLEKKAAGIELYAGGTKGHFLVKTSPLMFIGKNQFLYGHKEEQEEAPEESIFVQTKHHEYGQDADADMGGALSSQELTSLKEDIVCEEEDELAQQKSQLPSQSQIKSQTQVKSYAAQLKSQPGQLKTIGQVKSQTMLKSHGAPLKSFKARLNLREDIPQQVKGRGYGLAEDLAQVRQQPAKVHRLKGKHRQSRKTAAFYPQFRRRSRPYPRYFVQFQEQLQGSVHHTKSFYPGPGMCYCPRGGVILYQDAFTD