lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Toxic component of a type III toxin-antitoxin (TA) system. An endoribonuclease that is probably sequence-specific. It is neutralized by its cognate antitoxin RNA AntiQ, which has 2.8 35 nucleotide-long repeats. Cannot be cloned in L.lactis subsp. cremoris strain NZ9000 in the absence of the antitoxin gene; expression in strain NZ9000 even in the presence of antiQ inhibits growth in a bacteriostatic fashion. Confers resistance to 936 and c2 phages but not P335 phages in L.lactis, causes an abortive infection (Abi phenotype). Viral DNA is replicated but not cleaved from its concatemeric form, while the viral major structural protein is produced normally in the presence of this protein. Operon expression in E.coli confers resistance to 3 phages of the Myoviridae family (T4, RB69 and phage 2) and 1 of the Siphoviridae family (T5), but not other tested phages (T1, T3, lambda vir, HK97, Mu and pilH alpha). The presence of this operon in L.lactis subsp. lactis strain IL1403 during phage P008 infection alters the viral transcription profiles.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSFFYKEILRMTLRFFTVTDEYIAYLRKFESKVHYQYENNASTYVGVVLKKNDFNYFIPLSSYKKGNPEKDKAMKKRSRIVTRLFEIGNINNPLGYLLHHNMIPVPDSELIPLPLDLKKPKHKMMQKQLIYMKSISEKIENKSEVVYRKAAHEKDGYYLKFSCDFKLLEAKATLYSKKSTFQ
The following text describes a protein:
Function:
Involved in nonsense-mediated decay of mRNAs containing premature stop codons.
Miscellaneous:
MISCELLANEOUS: Present with 1250 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSNVAGELKNSEGKKKGRGNRYHNKNRGKSKNETVDPKKNENKVNNATNATHNNSKGRRNNKKRNREYYNYKRKARLGKSTENEGFKLVIRLLPPNLTADEFFAILRDNNNDDGDKQDIQGKLKYSDWCFFEGHYSSKVFKNSTYSRCNFLFDNLSDLEKCANFIKTCKFIDNKDNITIPDMKLSPYVKKFTQTSKKDAALVGTIEEDEIFKTFMNSMKQLNENDEYSFQDFSVLKSLEKEFSKSIELENKIAERTERVLTELVGTGDKVKNKNKKKKNKNAKKKFKEEEASAKIPKKKRNRGKKKRENREKSTISKTKNSNVVIIEEAGKEVLKQRKKKMLLQEKLKISNSSQPQSSSAQTQPSFQPKENLFVPRVKILHRDDTKK
The following text describes a protein:
Function:
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MRRKGTKPSTACHQEEGPPPSEDGALSEGEKEQPDCEVDSAAAAETPGEELDSRSLEEILNSIPPPPPPAMASEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHTDIQSCTVEVHFQKIIDKEGDDYDVLPNSNFYVSRTAYRDNTSVYHISGKKRTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFKKKNHICQYYIYDLQNRIAEMKTQKEKIHEDTKEITEKSNVLSNEMKAKNSAVKDIEKKLNKVTKFIEQNKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEELKSIPAKSKNVINETTTRNNSLEKEREKEEKKLKEVMDSLKQETQGLQKEKEIQEKELMGFNKSVNEARSKMEVAQSELDIYLSRHNTAVSQLSKAKDALITASETLKERKAAIKDINTKLPQAQQELKEKEKELQKLTQEEINLKSLVHDLFQKVEEAKSSLATNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDIAISSCCHALDYIVVDSIDTAQECVNFLKKHNIGVATFIGLDKMAVWAQKMNKIQTPENTPRLFDLVKVKNEEIRQAFYFALRDTLVANNLDQATRVAYQRDRRWRVVTLQGQIIEQSGTMTGGGSKVMRGRMGSSVVDEISVEEVNKMECQLERHSKQAAQVQEQKVQHEEAIVKLKQSEREMRNTLEKFTASIQGLSEQEEYLCVQIKELEANVLTTAPDKKQQKLLEENVNVFKKEYDAVAEKAGKVEAEIKRLHDTIIDINNRKLKAQQNKLDTINKQLDECASAITKAQVAIKTADRNLKKAQDSVCRTEKEIKDTEKEINDLKTELKNIEDNAEEVIKNTKDAEKSLPEIQKEHRALLQELKVIQDNEHALQKDALSIKLKLEQIDGHISEHNSKIKYWQKEISKIKLHPVEDNPVETVSVLSQEDLEAIKSPDSITNQIALLEAQCREMKPNLGAIAEYKKKEELYLQRVGELDKITSERDNFRQAYEDLRKQRLNEFMAGFYVITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNITKSVAVNPKEIASKGLC
The following text describes a protein:
Function:
May inhibit cardiomyocyte growth.
Subcellular Localization:
Secreted.
Sequence:
MRRLEMSSIRLVTLLVVKLCLALNDDEKRIILEKHNFYRSQTEPSASDMIKLTWDTALEKLAKSYAEKCIWEHNKDRGFIGENLFVMSGSSLDVVLGLDDWHKERDYYNFTTGTCQEGQMCGHYTQVVWAGTERVGCGQKFCEKLEGVDDENMYLLVCNYEPPGNFEGESPYKEGIRCSECPPDHVCLDSLCLKMKDMEKASTVVVDSSTATSTSLEGIYTEKTQTNPVEVMEYTSPTLPTQLMHNSRTKVFFTTTESSTSKKISEGIGISVASTQGSEDFRTTQKIQESDPTQLHRIGSTGSTQQGTSPYFVKGVSTSAQPPALSQLPLIPESSAKVLTEKTLPKSVHSAPQPTHGTLTSDKPLANKAITQPVVKKTEKQKDEPFQPLIKTLISSSQSNPKAKDNVSRSSASAGQSKTDQYKANSKAKITSRLGKPSTAQKRFYQSINSDKTHFDSSVYRPAKHRPNCPFPCVNQAMKFSVIFPLYMTNNVSPVGARDHKWWKIPNSSKNPSHKRPCKPTGYKRGMYSLYKPKQKSNWDSLENIIGSGKA
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MHHFQLQLPYVEILLMVATQPIATNKDSTTVKAACHEVAFNDKLAAAFKQKIDGLAAKKSQLLKEAEALDAAACLATDHKTKKATRMLASIGSSRAAATEANADAVKQLKASIETLKRRNAQLMAAIAFNTKGDLTISHDASAQKSDLIGGAGAKSCSVTITQPPKNEHGCQSSLVNDPAINDDVNNVQNLDSYQAIHDKAFQLTDIAADIGNKGDYGSATPATHNKKIACVDTGDRSNKLGSVAKGIILTNFARKADWNTPTKNTIKSKGDGTDCEDDQDSDKKAFVTAKAAGYAICNGRRQTVTEPETLSQLTMDALKEQKDVQEAAMLITAGPTAELPDTDKQKEAVVALVGEGKTTVHDKFLKDMEANKLDFKIGDKHVNKGIVSISGTEDYARAIGFCLGDQYRKEKAQKKVESVTAAAPENNKECKGETDEGKCNEKVGCEFKDGKCEAKVTETTGTNGKITNTTESNSFVINKAPILLEFLAL
The following text describes a protein:
Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Involved in the positive regulation of MAP kinase signaling and in inhibiting oxidative stress-induced cell death.
Sequence:
MGCSPSTLPPAPSAGQTGERGSLPLDASEKDESRLFCIKLRRSRLRRCSCGGVTLQPPSDGNGSTAGDNLCGQVLLNPLQTKSEADYEKLSTGKKDSIVTVAALGNFTHSVVRRATGSTGTSGTSSSGGNSRPGHRKSSLALALTPEDEPMDVYQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQRHQLDVTLVKSKEEALDTLQKSYATAQCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFFEKDDVLIALLDAGVNRCVAETTNLAMCSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFIDMPQLITYMQINYSQWKKYDEQGVNTLAEIMAKQPPVGKMANSK
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSVLMPQLLRGLTGLTQRLPVQRAQIHSKPPWEQLRTMDVAVGLTSCFLCFLLPSGWVLSHLESYKKRE
The following text describes a protein:
Function:
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting.
Subcellular Localization:
Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Mitochondrion membrane; Single-pass type II membrane protein.
Sequence:
MSVQSGDGADMSALPFLRLLVAGASTVTLVPLVSLVCIYNTKPDFIIKAIRKVVIWRAGLTVKFVTVDGYRFAYAERGRPTETQPSIIFLHGFSTSKDTWANFIKALPRNLHIITLDLPGHGDSDRNPNQDLSMEGQANTLRRFVCAVGLDRKPLHLVGTSMGGGIAGLYAATYRENIALLTLFCPLGVVPPVHSRMMKAYLEGRNMLVPTTLDDFREMAQINSYRYKIGKLKLPDKLLYCALADRTPHNDFFQKLSDELGRKEKWDVLQRSMGNICAPTHVIWGREDDVLDVSGADILREGVSNCRLDILDDCGHVLVNERTRQAVKVFIDFREQVLNGHKK
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MGIAMLLGTFVVLLLIGVPVAYALGAAALATLLYLDLPTVVLVQQISAGSGSASLIAIPLFIFAGELMLRGGISERLIALASSLVGRVRGGLGQVSVLSSLFFGGVSGSAIADVSAVGGTMIPQMIKRGYDRDYAVNVSMTAALVALLVPPSHNLILFSAAAGGGLSIADLFAAGIVPALLMTAAMMVTGYAVARHRGYGTEPFPGWRAVALRLFGALPGLGLVALIFIGIRAGIFTAVESAAIAVVYALIVTALLYRQLRWAEFFAAVTHAARTTGVILFVIATAAVFGWLLAYLQVPAAAVKFLQAIADSKNTVLLMIVVMLLLLGMFMDLAPKILICTPIFLPVVKAYGIDPIHFGLVMVLAGGIGLITPPIGSVLFIGTSIGEITVAQSMRTIWPFWLAALCVLLIVAFFPELSLWLPRALRA
The following text describes a protein:
Function:
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MLFNSSHVRDALPMLDRSQPILVKFGFDLINIVDVNAKQQAITVYGWVRQMWNNSLLTWDPALFGGLDILHVSAKDVWVPDILLFYNVDEQDQTAGGRTTYKTDVIMYSNGTNKWRSPALLKSICKIKVKFFPFDSQTCKLKFGSFSHDITTLDMSPMNLTFPTRYYQKNGEWSIYDIDIVGSHSQYNGFPNQFADVTLTIWMRRESLDYFINLIIPCCLISSMIFLGFVLPPESGERIGLSITVLLAMTVFQQLTSEIMPAYDFPLLGQYYFAIVLEIGASLVVTTMILNFYHRTNRKMPQWLRTLILNW
The following text describes a protein:
Function:
Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.
Subcellular Localization:
Cytoplasm, cytoskeleton. Membrane.
Sequence:
MNIYKHRIILDAGELREKHPNCIPLTLEKDPRSDIPDTDMKKFLEYGDMPLRDFVSFIRTRIRVSRKKRIFVFCRNTEPPFDALMSTIDEENKDEDGFLHITFIGEGRVSGSNEEQ
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling. Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid. Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
Subcellular Localization:
Nucleus.
Sequence:
MEETQQRKRKRRRRRDSELSRSAPLGSADADTALCLLLASVSKINAGGRGGSDPLPSSSLVKRCLRKVLSFLSKSDDPVSSFRKIPLAALFSVLPMLLKSNSLDIACLSAKLVGMASLCSFDMNQRIASDAEILESLVSGLRSSNRRVKLSACRAVSDLSTSLVGRQSLLEHSALETLMVCYRQVAKCFVDSVALFPVDNGFARSHITAAKEHELPVSLLDAVIVLVNSCNIKQLERVPSELSESFFFLLKELWTKLHPRMYNSTVCSQQKDLLSNMRVNDLAESIFRLSIRVQCTTFLPIDQIRRSIFGLPQSSFEDFIEGYWEVSPFLISRTSRAVDEENILNSFLNCINPKDVVHLLLSSVLHCAVSCPPIASDELDIFNFLKKERDSLAYKDGYTVAMRGMEFHFKSIAAITGDILYIPRGYVHEAHTTNDVQKDSAGLSLHLTLAIEVEAPFEWEGFIHIALHHWSQNLKQHVYSDLMTGTPYTACIRLLHFMIMLLGDVDPMFRKACLVNSICFSRDTNHWLYKSHVAIFRDLIDKINESSKFMETLQSMERRIRWLESFNLKDEEADERYEYYVCDVDAEHLFGLHPEEKETLEAAFLTVKSEFCKQVLLEDVLPMYRLLLEKYRIVRKQYLNGMLSLHRDLD
The following text describes a protein:
Function:
May have a role in cell motility. It has high affinity for both G-actin and F-actin. Binds to vesicle membranes via mannose residues and, by way of its interaction with actin, links these membranes to the cytoskeleton.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Primarily on Golgi and vesicle membranes.
Sequence:
MELLRQGEHLHSTSRSTLESKCRKYKLIMQNDGNLVLYIGSLKSQSDEYCLWSSASCGKGHGPYRLSMQEDGNLVIYDSRNSAIWASGTMGHGVRGHYSMKLRSSGQIVVYDKYKQILYSSKPCTRDHLLSLPCAKPSGHPQSAYPPQQPGYGYPAQPGYPPQPGYPPQHGYPPQHGYPQQPGYY
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLTNSKNNDEMKIENKSLRSKATAFNLIRTTNISSYFLDPSITPSNDVLDFFNSMRRPSFFLFYTLASYFFLVASPVTGDKRDVDIGVVLDMGSMMGKTIKQCLEMGITDFYKVHPNYSTRVVLRVKDSGNDSVGAASAALYLMKNFEVQAILGPQKSSQASFVIDLGTKAHVPIVSFTVNTPSFSPTKTPYFIRTGSNAKFQVDALAAIIENYGWKSVNLIAEDTEYRTGLNPYLDDAFQSVDARIVNRSMISPSANGIEIRKELCNLKAMQTRVFVVHMLPPLSHRFFKKAKSVGMMTEEYVWIITETTMEYPSNSKDVIGVLGVKTHVNITKEFRSRFNKKGKYQLNDVDGLRAYDTAQAMAKAVETGGEGNLDQFDHRLNSSNNDPFSTLGLSKNGPRLREAILATKFKSTASGGTFHLEDGELPPPSRFEIINFRPDGWKKLGFWDKEDGLKLNTLQDIIWPGDSKNQPKGWQIPAVGKLKVGIPEKGGFFEFVNTTDPQNITGYCIDIFEAAIKSLPYSVQYDYRVCNLSQSPGSYDVLVGQVYNKTFDAAVGDVTIVANRSRYIDFTLPFTESGVSMLVPVKKDGDIANGWIFLKPLSKGLWLGTLAFFFLTGFAVWFIEHRMNTDFRGNRIQQMGTIFYFAFSTMVFAHKEKVVSNFSKFVIVIWMFVVLILTSSYTASLTSMLTVGQLKPTLTDMSELVKNNNSVGYQDGSFVRELLINQLKFNKTQLKPYKTSEEYFHALSKGSRNGGVSAIIDEIPYIRMFLKDHCKKFTMVGKTYKTDGFGFVFPKHSPLVSDMSNAVLKVTQGEKMKYIEKKWFGDKSWCPVESSGVYDSNKLQFDSFWGLFFITGLVSLLSMISFFSKFWYVNSESLKTSIAAEKSLWGKVSTSMKRFDDKEEEECSSRQMFMNHQMMQNMSAVDTSRDDTPQSATPSGYASHSPPPPITPERSFHSSI
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MASSHQQQQEQDQSALDLITQHLLTDFPSLDTFASTIHHCTTSTLSQRKPPLATIAVPTTAPVVQENDQRHYRGVRRRPWGKYAAEIRDPNKKGVRVWLGTFDTAMEAARGYDKAAFKLRGSKAILNFPLEAGKHEDLGDNKKTISLKAKRKRQVTEDESQLISRKAVKREEAQVQADACPLTPSSWKGFWDGADSKDMGIFSVPLLSPCPSLGHSQLVVT
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MPYYVSDVNPDYTAALGLFQHLNTEELQKLLNDDSRVESMVKDLQQNAESEREMLLASNKSLADFNLSREPKMRQSRQQIKELYEQAQELMQEVEQRKKTLDSMGGQSSLETMLALLQTSAAQSEEDSEKIASSFLEGETTVESFLEQFADARKLAHLRRVKVDKMTELLTNRSRNPSRLPGGAPPPLPSRPAPPAPAPMPAYPPAGAAPYPVAHFAMPMPWQ
The following text describes a protein:
Function:
Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRNKTWLDRQSIGTLLLYGGLARVVLLIYAAFHDYYFRVKYTDIDYMIVVDGARELLHGGTPFDRTTYRYTPLLAVLVIPAVLIANPLGKVVFALSDLGAAYYCFHMLLRFSTERSAKWMVVILILFNPVVLNVSTRGNSDMLISCMSMGVLAKFAEGRYFTAASILGFAVHFKIYPIIYALPLVLGVWERAKQERFFGRLAHTASVVVGCGLCFTVAFAVPTYVCYLVYGQQYLDEGFIYHIHREDHRHNFSPYWLLMYLNMGRRDLGVGVDYSAGLFAFLPQFAVLCYASWKLRKNIAHACCVETILFVAFNKVCTVQYFVWFLPFLAFVFCEPAQPKWLTGVTNAPKSERPSMLSAVAAILMWSLMIPLWVWTAYGLEFEGRNHYGRLWIVSCVFYLATVSLAAWLGRLCYRSRITVSIKDHRPASKRA
The following text describes a protein:
Function:
Acts with RNA polymerase to initiate transcription from intermediate gene promoters.
Sequence:
MDNLFTFLHEIEDRYARTIFNFHLISCDEIGDIYGLMKERISSEDMFDNIVYNKDIHPAIKKLVYCDIQLTKHIINQNTYPVFNDSSQVKCCHYFDINSDNSNISSRTVEIFEREKSSLVSYIKTTNKKRKVNYGEIKKTVHGGTNANYFSGKKSDEYLSTTVRSNINQPWIKTISKRMRVDIINHSIVTRGKSSILQTIEIIFTNRTCVKIFKDSTMHIILSKDKDEKGCIHMIDKLFYVYYNLFLLFEDIIQNEYFKEVANVVNHVLTATALDEKLFLIKKMAEHDVYGVSNFKIGMFNLTFIKSLDHTVFPSLLDEDSKIKFFKGKKLNIVALRSLEDCINYVTKSENMIEMMKERSTILNSIDIETESVDRLKELLLK
The following text describes a protein:
Function:
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
Sequence:
MGSRFDEMRIFAGNGNLPLARAISERLGVPLGDVTIVKFSNENIFVRLNESVREKDVFVIQSLSMPDLSDRIMELLILLDACKRASAGRITAVIPYYAYGRTDKKDQPRVPITARLLADMIQVAGAHQVMTIDLHAGQIQGFFSIPMDELTAMNLLVRYFADKGWNDLIVVSPDVGFAKRARNFAEALNAPLAIAEKRRLQHFDRKDGSLTVPEILNLIGDVRGKRCLIVDDEIATGSSILEVVQLLEKEGASEIYACCVHPVFAGNAIERLRASPIRELVVTDTLPVAPERRWPGLTILSVSTLIAEVIQRIHSGVSVDTIFQHRRHPALS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MGAGKQLRAPPLYRQSHGAPGVREKPPDTGRMMGKKDPLSDRILTLTLEIIRLLTGEDCVVMKKSGDTTPPQSCADCTLGGACRHHVTPTVGALPAPGSALQKENSEKILELISNIIHLLTGEVAIRCEDVAVYFSMEEWEYIRENEALYTGESKENVQQRPPLGCTNEASDEIKAAPEAELPPSNNPGLCTDGNITNTDISMHPAPTEPSPLYDERSQSDLSISELREQRQVMPAEGCSRNKDLPGNSTPSSIKEEYSLRGAEAHCDDRVEALTEQVGRPYTPSPAMGCSLDNDTANSIKQETDSWDIESQSDCGSEALTGTDTSSYGLGHSQSNSDTLLSSPGVRDKAVSCKGAKQSHSTVSKRTGLIHGIDTSSDTLASLYTEEGNQSDCSTNAHTEPTTGTDPSACVGGCSVNTGLPEYTINTSAYASHPGTDASPGKYTFDGYQKPFIDTRNQNTEEKLYVCHECGKSFSHNYLLVRHQRNHSGEKPFSCLECGKSFTHNYLLMRHQRYHTGERPFSCSECGKCFTQVSQLNYHQKSHTGEKPFTCSKCGKCFAYRSYLIIHHRVHTGEKPFTCTECGKCFTHNYLLVRHRKNHSQEKAFACSDCGKSYTHPSQLANHQRNHAREKPYTCTECGKCFSHNYLLLRHQKNHSGEKPFACSKCDRCFAQMSQLNYHLKGHTGEKPFPCPKCGKRFAYHSQLLIHDRTHTGERPYKCMECGKCFTSRSHLNVHLQFHTGEKPFPCTECGKRFTRRSHLSLHYRFHGGEGGYSCSICGKSFSLHSQLNEHLQLHAGAALFKCSECDIYFKSRSVLLEHYRFHTGEKMFYCSECDKCFPSRSQLIVHYRVHMGPNILACPECDEGFERHSQLIEHLRTHTGDKPFSCSECGKCFGFQRNLNAHVRVHSDQEAAGGGVC
The following text describes a protein:
Function:
Adenine glycosylase active on G-A mispairs.
Sequence:
MPRGSACKQSMCGEWLTPLGSFATHEYYRSVQEEVIAWWRQHQRQDLPWRQTLPRGSGDLSGAVDGEKHRTSATTARYDPYQVWVSEVMSQQTRMETVIPYYVAWMKRFPSIEALAASTEDEVKSVWAGMGYYRRAMYLRKGAKYLLERSKEKEGTAAVCMPSSQEELLKVPGIGPYTSAAITSMCFGKPVCSVDGNVIRVLSRLRGARDFDPKVPANVKEAAAWGQRLMGNSPTTSAVVCQDPSALNQGLMELGASVCRPSGAPLCTSCPLQRFCRASALLRGGDIEAIEGVIPVRAAKMAKRSARKLCVVHEMSASRIGDARRFVVVRRPANGLLGGMLEFPTVNASAADDEEAVVPLLKHPLSMLAWKARARPTFARLCGNVRHIFSHIVMDVGVAHVQWPADADGAALLKRVAEVVDDHCAGDCCNELPTAARIFLMSEADLRENAPSRLMLKVLQKVSSVEVKQVRTSRTGKRAIQESSDSLSPHKKVARGEQARS
The following text describes a protein:
Function:
Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force. Its role in the complex is unclear but it may be involved in the assembly and stabilization of the TIM22 complex.
Miscellaneous:
MISCELLANEOUS: Present with 4440 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MLLFPGLKPVLNASTVIVNPVRAVFPGLVLSTKRSFYSINRLNAENKINDIANTSKEASSSVQMFKPPEFSQFKDSYQKDYERIAKYTLIPLTMVPFYASFTGGVINPLLDASLSSIFLIYLQYGFTSCIIDYIPKEKYPRWHKLALYCLYGGSMLSLYGIYELETKNNGFVDLVKKLWNENDDHLYIFGRN
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Subcellular Localization:
Nucleus.
Sequence:
MDPTISVSKGCFVYKNGATRAGKKAASKRKRPAAESSSLLGKEVVQQPFYEEYRKAWNQINDHIADLQHRSYARTLEQLVDFVVGQAERDTPDEVLPTAALLTGINQPDHLSQFTALTQRLHAQRAAMVCVLQSRDCATLKAAVETLVFGLVEDNAEVEQMEDEDEDEDGAERDRKRLRRSQCTMKQLKSWYTNNFDSEQKRRQLVVILPDFECFNASVLQDLILILSAHCGSLPFVLVLGVATAMTAVHGTLPYHVSSKIRLRVFQTQAAPTGLNEVLDKVLLSPKYAFHLSGKTFKFLTHIFLYYDFSIHGFIQGFKYCLMEHFFGGNAFALCTDYSKALGRIKQLTHEDMETIRRLPSFRPYVEQINDCKRIIAVLTDDDYLKKKLPQLLRDCLLHFLLFRCSLEFLTELVGDLPRCPLGKLRRELYVNCLNRAIISTPEYKECLQMLSFLSKDEFVAKVNRALERTEQFLVEEIAPLELGEACTAVLRPKLEAIRLAVDEVVKATMATITTTSPNETRQATDHLTPVASRQELKDQLLQRSKEDKMRHQLNTPTTQFGRALQKTLQLIETQIVQDHLRALQDAPPIHELFVFSDIATVRRNIIGAPRAALHTALNNPHFYMQCKCCELQDQSLLVGTLPDLSVVYKLHLECGRMINLFDWLQAFRSVVSDSDHEEVAQEQIDPQIQARFTRAVAELQFLGYIKMSKRKTDHATRLTW
The following text describes a protein:
Function:
Fungal ribonuclease involved in fungal defense. Highly specific and highly toxic fungal endonuclease that cleaves a single phosphodiester bond in the 28S RNA of eukaryotic ribosomes at a universally conserved GAGA tetraloop of the sarcin-ricin loop (SRL). The damage of the SRL inhibits the binding of translation elongation factors and halts protein biosynthesis, ultimately resulting in the death of the target cells. Shows antitumor activity. Exerts cytotoxicity and induces apoptosis towards rat glial cells and human glioma cells, and also displays some activity towards human neurolastoma cell lines. Shows a strong entomotoxicity against Aedes aegypti larvae, yet no nematotoxicity against nematodes.
Subcellular Localization:
Vacuole lumen. Note=Possibly sequestered into the vacuole to avoid its toxic activity on ribosomes.
Sequence:
MSESSTFTTAVVPEGEGVAPMAETVQYYNSYSDASIASCAFVDSGKDKIDKTKLVTYTSRLAASPAYQKVVGVGLKTAAGSIVPYVRLDMDNTGKGIHFNATKLSDSSAKLAAVLKTTVSMTEAQRTQLYMEYIKGIENRSAQFIWDWWRTGKAPA
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Miscellaneous:
MISCELLANEOUS: Present with 784 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSELGAKYQQLQNELEEFIVARQKLETQLQENKIVNEEFDQLEEDTPVYKLTGNVLLPVEQSEARTNVDKRLEFIETEITRCEKNIRDKQEELEKMRSELIKLNNTAASTGPGR
The following text describes a protein:
Function:
Involved in lateral root formation. Regulated by the transcriptional activators ARF7 and ARF19.
Sequence:
MTSSSSSSGSPCGACKFLRRKCAKGCVFAPYFCHEQGASHFAAIHKVFGASNASKLLSHLPISDRCEAAITISYEAQARLQDPIYGCVSHIFALQQQVVNLQAELEILKQQAAQSMIFADSPTSENPNSYYGDTTKAPYHHDHQNIYHHHDQTHLVYQTGSSGTVQHGDATESSYHNETSSGMGEFSIYSDLEQHLNTFNQDHLKELQSANFGYISFS
The following text describes a protein:
Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAATALFRSIRRRDVVSAPLSVYKSLAGNAQPSWGSSYIGQNYASFSRAFGSKPVVNDILGTGLGTNNAIREEREKSKSTEAAIVGAQLTRSFRALDVGTSKRLFSTISGDIKTTQEEPKIKSFRPLSPHLSVYQPQMNSMLSIFNRISGVYLTGVTFAGYLLYLKMGMICLTYPSFYQVLYHTQQQLPVITSVTALAAIYHTIKSTHSLLTH