lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSNAINVYSAPEVHTAIEESLPAVFSRLGYKQDFRLLDTRLLLGYLTAITAAVSFVLDRKFKWDDVLIYQKALVGLYVVFSSAFWLFSRYGERHAVYQGQQGQERITVRMQPEPGSEHSLVTLEDGAGGRLEARLAAPGVFSADGHLQFGKLHRWFEEQLGLLVQKKRQ
The following text describes a protein:
Function:
Required for the assembly of cytochrome c oxidase.
Subcellular Localization:
Mitochondrion intermembrane space.
Sequence:
MADKSNSEDNKPKFMKNEDGTPMTQEQLRQKYGVDFTKEGRDGKLKYGPDDPTAMSNRVQFLAKADSQYYDPCAEASKMSLNCLERNNYKKAMCEEYFQIYRDCKKMWVSNKKQSGEIFETENITNPAGAATEGQEEWFPLVDQYLYILLLTWNVCVPYEAYMV
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
TMRAFDNAVLQEARMFNETPINPRKCAHILTKILYLINQGEHLGVMEATESFFAMTKLFQSNDPTLRRMCYLTIKEMSNLSEDVIIVTSSLTKDMTGKDDNYRGPAVRALCQITDTTMLQAIERYMKQAIVDKVPSVSSSALVSSLHLLKTSFDVVKRWVNEAQEAASSDNIMVQYHLPAAKNWWDHKPAKVLENEHAKILWDFRIQTDKVLEHNTPDITVVEKNKKPVQVVPVVMGTLGAVPKDLSRHLETIDIDKITICQLQKATLLGSVAMKHPSAVTACNLDLENLVTDSNRSIATLAITTLLKTGSESSIDRLMKQISTFMSEISDEFKVVVVQAISALCQKYPRKHAVLMNFLFTMLREEGGFEYKRAIVECIISIIEENSESKETGLSHLCEFIEDCEFTVLATRILHLLGQEGPKTNNPSKYIRFIYNRVVLEHEEVRAGAVSALAKFGAQNEEMLPSILVLLRRCVMDDDNEVRDRATFYLSVLEQKQKALNAGYILNGLTVSIPGLERALHQYTLDPSEKPFDMKSVPLATAPIIEQRTENVPISAVKQPEKVAATRQEIFQEQLAAIPEFRGLGPLFKSSPEPVALTELETEYVIHCTKHTFTNHIVFQFDCTNTLNDQILENVTVQMEPTEGYEVIGSIPAKNLLYNQPGTCYTLFALPEEDPTAVACTFSCMMKFTVKDCDPNTGEAEEEGYEDEYVLEDIEVTIADHIQRVLKPNFAAAWEEVGDEFEKEETFTLSTVKTLEEAVSNIVKFLGMQPCERSDKVPENKNSHTLYLAGVFRGGHDLLVRSRLVLTDAVTMQVTARSGEEIPVDAVMASVG
The following text describes a protein:
Function:
ATP-NADH kinase with a low phosphorylation activity of both NADH and NAD(+) to produce NADP and NADPH by using ATP. UTR1 is responsible for essentially all of the NAD/NADH kinase activity resident in the cytoplasm, whereas POS5 is responsible for all mitochondrial NAD/NADH kinase activity and consequent mitochondrial genome maintenance. YEF1 can substitute for UTR1 when overexpressed.
Miscellaneous:
MISCELLANEOUS: Present with 300 molecules/cell in log phase SD medium.
Sequence:
MKTDRLLINASPETCTKGDAEMDTMDTIDRMTSVKVLAEGKVLSNFEEPGLMRCGYHDAKNWVRRLSSETIVGEDTSNLYPFYVDTAYDVRRLRKDLINAKVDLQVENLIIICNINDISTVFLMREVVEWILRNFHSITVYVQDIFKKSTQFAVGDLCKDSNCSKNRVKYWSKEFVKKHDSFFDLMITLGGDGTVLFASSIFTKDVPPIVPFALGSLGFLTNFEFQNFKETLKHILTDEVRINLRMRLQCKLYRRNKPEIDAATGRKICYIDFISEHHVLNEVTIDRGPAPCLSLLELYGNDSLMTKVQGDGLIVATPTGSTAYSLSAGGSLISPSVNAIAVTPICPHTLSFRPIILPDSMELKVRVDMNSRGTSWVNFDGKDRVELKQGDYVVITASPYSVPTIESSASEFFESISKNLNWNDREEQKPFAHILSPKNQEKYRLDSSKNGNDTISNPLESSCISSDAQDEERKSVTETETEIVVERTRQAHFAI
The following text describes a protein:
Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
KGKSIMANLLVISVLSLLIGSGFCCDQPSVDSSYYTSTNLKLGKNAAFVVELTVKCKNNVQDLMLYADVNGVQYPVTKSPEGNNYQVSWTAKNKKSPAALFDVKFFDESGYNALKKAARINQDANTVKPLFSVDVKHHGMSSGFWVSSELIALAVASLIFYVVCNERSAVIS
The following text describes a protein:
Function:
Putative gamma-glutamylcyclotransferase.
Sequence:
MSIMVAPNSWTLNNSVRCSAQSVVSTRKKETSMPASKVAHVDSSTKESSVVDSPQKALEASPTSLAFVYGTLKRGFGNHWLMEEQMSKKHARLVGTAQTKMRYPLVCGPFQVPFLLMYPGEGEHVRGELYQVDSHCMELLDELEGVSKDHYERRQIVLTGIELDPSFKFSLQNGLNGFSANQGYALMDAVVQPGEVKAEAYFAHPHYTPGMYRAPHLEAYTEKEAATYTRRIHRPQNRTFLEHVYHWIEEQKHEVPLPGANN
The following text describes a protein:
Function:
Cell polarity factor essential for the bipolar localization and function of structures containing the cell-end marker tea1 during the normal cell cycle. Regulates cell polarity in complex with tea1 and together with the stress signaling MAPK cascade, contributes to cell polarity maintenance under stress conditions. Required for the localization of for3 at the cell tip specifically during initiation of bipolar growth. During the new end take off (NETO), formation of a protein complex that includes tea1, tea4 and for3 is necessary and sufficient for the establishment of cell polarity and localized actin assembly at new cell ends.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Through it's binding with tea1, is transported by the cytoplasmic microtubule system and is localized at cell tips, microtubule plus ends and cytoplasmic dots.
Sequence:
MLHMNSASSADSMEIMESHFDPTQQNDSTIIESRYSPEEYLEQSFEIQRIISGENSEPQTVASQEISDSQEEDTTLTSSQFEDCGTEYNEVVEDDEFRSEDEDDFMDEEEEYALYEAELSSSPSIHEEVIDCNFVHAIRGFEATVEGQVDATKGDMMILLDDSNSYWWLVKMCKNLAIGYLPAEYIETPSERLARLNKYKNSETSNSQQSVTLPPLDIVEKTLEAPSPNFRIKRVTFTCSSNSSDDEMDSENDYEAMVNRTVAENGLEIEFSDSSDSSLSAEYRSESEDHVTDSPAYVDLTELEGGFNQFNSTSFQSTSPLGLEIVETEINGSSTTADSKNSHSPYSKFSSAYPDAENSNISKINISIAGNKELYGNATQSDPSLYSTWIANKHKTASSATVDSPLRRSLSVDAMQSNASFSSYSSTSNTDKSLRPSSYSAVSESSNFTHDVSRDNKEISLNAPKSIIVSQSDSFDTSNVTQDAPNDVEKEPISGQMPNNLSVQSLKQLEVYPIRHSVSIEMPSEKLLSPRLYSSSTPSSPTKGFQKDDEEDSENRKQADKVELSPSSLLRQMSLPVDSSSQSDAQCTTSSVYITAERKAFSQSSIDLSTLSNHHVNNEINRRSFAGGFTSLADELSEMRELLHESPAPLECNEEMVIPTPELDASSAIPSSSISHDEDLLPRKNTEESTSSSSFSSLITSPASLQYDENPFKQSVVAELNNNSSSVPFVDSAHASDIHAYDNDHVSTKNKEFNRRLREFILDPDSLSGLYWSVKSAGVRASRRVSRNIEGESVSSDLDDIFANVLKGLSDEMASLLNTNR
The following text describes a protein:
Function:
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
MTTEVGSASEVKKESDQLGADATKEKPKEVAENQQNQTSDPEEEKGSQSSPPAESQSSPRRQKKEKDPSESRGISRFIPPWLKKQKSYTLVAAKDGGDKKEPAQPVVGEQVLDKEESLPEEERRAKGDAEETAQRKQQEIKVDVKEEKPLQLVEEVSKEREEEKVKEIQEAEFMDEAAKRETKEVQTNELRAEKASLKAPKKTKTVQCKVTLLDGSEYSCDLEKRAKGQVLFDKVCEHLNLLEKDYFGLVFQENPEQKNWLDPAKEIKRQLRNLPWLFSFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHASHDLSDFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASSLIDRPAPHFERTSSKRVSRSLDGAPIDAVDQSLMKDFPGPAGEVSAPGPGVVSTAVVQDGDGRRDLRSPAKVPHMPLIEGKKNSLRVEGDNIYVRHSNLMLEDLDKAQEEILKHQASISELKRNFMESTPEPRPNEWEKRRITPLSLQTQGSKGDHLFKDILSMKEKHQMVAARTVEEKTQEADKRRAPESEGPCAGATDAVKSSLETLNVVEEKKQAEVGKDERVIPEEMNGKELSPGRGPGEMRKVEPGTQKDSTSLSSESSSSSSESEEEEDVGEYRPHHRVTEGTIREEQEEDEEEVEEAPGQAAKVVDREDPVPAASPVTHAGASVGPVETVPQEKVVAPQIPAEKSVNEGAVKQDTGEETEEEPQKVNGEVAHVDTDVLPQIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQTETKTITYESPQIDGGAGGDSGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIREAREQHPDMSVTRVVVHKETELEEGEE
The following text describes a protein:
Function:
Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.
Subcellular Localization:
Secreted.
Sequence:
MKHLLSLVCTLGAATLAASAAAEAGSMPSANGLDFVIDGEASYFAGSNAYWLSFLTNNADVDLALDHFAESGLKILRIWGFSDVTAEPSDNKVYFQLHQNGSSTVNTGPNGLERLDYIISGAEKRGIKLVIPLVNYWDDFGGMNAYISAYGGDKPGWYTNDKIQAAYHAYVKAVVSRYVDSPAIFAWELANEPRCSGCDTSIINQWATKTSSFIKSLDPNHMVAMGDEGMGLPGDSNYPYSYYEGNDFALNLAIPDIDFGTLHLYTTDWGVSNNSWGNKWVQDHAAVCKSAGKPCLFEEYGMKGNHCTYELAWQKTALATPGMAADLFWQFGENLSSGQTHNDKYTVYYGSNEWKCVVSDHVAAVAVRRYRLPVGGGQHGP
The following text describes a protein:
Function:
Probably activates the ArgJ gene that encodes ornithine acetyltransferase. Binds to its own promoter-operator region. Probably binds ornithine.
Sequence:
MKQPLNFTAELVPVAYAEALLDLVAEYGVSRQALFDAARVRPEVLDSPNGRLSFLDFNQLTYSAQALCGEPALGLVLGQRLNVSAHGILGYAVLSSANLGKAIQFALKYYRVLGLAYELELVLDDGRAELRAVESMPLGAASVFAAEGLMATLYSIACFLVGEPLQDVRVGFAYPPPAHARRYAEVFGVAAEFEQPWHWLSMPSEYLERPMALANPATVQMCEQQCEALLATLDVQEGLLTRVRRLLLARPGDFPDLEQAARELHTSGRSLRRHLSSLGTTYQQVLDDVRKRLALQYLTTTQLPLYEIALLLGFNDSSNFRRAFRKWTGKLPSDYREAP
The following text describes a protein:
Function:
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
Sequence:
MIDSDGFRPNVGIILANEAGQVLWARRINQEAWQFPQGGINDRETPEEALYRELNEEVGLEAGDVRILACTRGWLRYRLPQRLVRTHSQPLCIGQKQKWFLLRLMSDEARVRMDITSKPEFDGWRWVSYWYPLGQVVTFKREVYRRALKELAPRLLARD
The following text describes a protein:
Function:
Adenine glycosylase active on G-A mispairs.
Sequence:
MNKRARRSTRPTRRIIYTEDQDEEVGSRQPKQPTKPLKPIPKKTVDTVDSSSLSGLEDSPSGSLAGEPDACLLEESLALPLRIINTAGRAHSVSYHTSHLPQDRHLLTSRDPPSSSLQASLLAWFDLVKGNREMPWRKEVVGIANWTEQQKGQRAYEVWVSEIMLQQTQVETVKSYYLRWMTRFPTIFDLAKADVEQVNECWQGLGYYSRASRLLSGAKKVVERFAGVLPEDPLVMEKEVDGIGPYSAGAIASIAYAKQVPMVDGNVHRVLSRITALYAPQAAKATTKFLWSIAAALVPQDRPGDFNQALMELGATVCKPREANCTSCPLSKWCRAYQEKQVLCVLEGGQQTHPSRLKRRVVDDEDIEDVCNLCQPLESLRASSGASSSDGHVLIYPMAKERKKPALREVAVSLVIWKESAPEDQMESSLENTPLSTGQAKALLIKRPEKGLLAGLWEFPSIDLAESNDSTADERQKKIERLLGKTVVGFTTAISSRTEGVSDGSKYQIQRSPVQLPDIEHVFSHLRVTYKSSVLLIHSPTPPTLQNPSLPDRPAASGQAIWSPCNDILTANLGNPHKKVWNAWLTHSDLSPSSIPSSSKPRKRKSSALNDPHA
The following text describes a protein:
Function:
Plays a role in the stabilization of the primary polycistronic transcript of the petL operon encoding subunits of the cytochrome b6-f complex.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MVALLCSASLCGDISVGDACLVSNIKAKCRDNLVTGGLKFHALKIGSRKKHWRRKSMRCSVVSMKSSDFSGSMIRKSSKPDLSSSEEVTRGLKSFPDTDSSFSYFKSVAGNLNLVHTTETCNYMLEALRVDGKLEEMAYVFDLMQKRIIKRDTNTYLTIFKSLSVKGGLKQAPYALRKMREFGFVLNAYSYNGLIHLLLKSRFCTEAMEVYRRMILEGFRPSLQTYSSLMVGLGKRRDIDSVMGLLKEMETLGLKPNVYTFTICIRVLGRAGKINEAYEILKRMDDEGCGPDVVTYTVLIDALCTARKLDCAKEVFEKMKTGRHKPDRVTYITLLDRFSDNRDLDSVKQFWSEMEKDGHVPDVVTFTILVDALCKAGNFGEAFDTLDVMRDQGILPNLHTYNTLICGLLRVHRLDDALELFGNMESLGVKPTAYTYIVFIDYYGKSGDSVSALETFEKMKTKGIAPNIVACNASLYSLAKAGRDREAKQIFYGLKDIGLVPDSVTYNMMMKCYSKVGEIDEAIKLLSEMMENGCEPDVIVVNSLINTLYKADRVDEAWKMFMRMKEMKLKPTVVTYNTLLAGLGKNGKIQEAIELFEGMVQKGCPPNTITFNTLFDCLCKNDEVTLALKMLFKMMDMGCVPDVFTYNTIIFGLVKNGQVKEAMCFFHQMKKLVYPDFVTLCTLLPGVVKASLIEDAYKIITNFLYNCADQPANLFWEDLIGSILAEAGIDNAVSFSERLVANGICRDGDSILVPIIRYSCKHNNVSGARTLFEKFTKDLGVQPKLPTYNLLIGGLLEADMIEIAQDVFLQVKSTGCIPDVATYNFLLDAYGKSGKIDELFELYKEMSTHECEANTITHNIVISGLVKAGNVDDALDLYYDLMSDRDFSPTACTYGPLIDGLSKSGRLYEAKQLFEGMLDYGCRPNCAIYNILINGFGKAGEADAACALFKRMVKEGVRPDLKTYSVLVDCLCMVGRVDEGLHYFKELKESGLNPDVVCYNLIINGLGKSHRLEEALVLFNEMKTSRGITPDLYTYNSLILNLGIAGMVEEAGKIYNEIQRAGLEPNVFTFNALIRGYSLSGKPEHAYAVYQTMVTGGFSPNTGTYEQLPNRA
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQYAVRVIGSNFAPTVERDEFLVAEKIKKELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLSLSEDPRRQPSKVSSYATLFAQALPRDAHSTPYYYARPQTLPLSYQDRSAQSAQSSGSVGSSGISSIGLCALSGPAPAPQSLLPGQSNQAPGVGDCLRQQLGSRLAWTLTANQPSSQATTSKGVPSAVSRNMTRSRREGDTGGTMEITEAALVRDILYVFQGIDGKNIKMNNTENCYKVEGKANLSRSLRDTAVRLSELGWLHNKIRRYTDQRSLDRSFGLVGQSFCAALHQELREYYRLLSVLHSQLQLEDDQGVNLGLESSLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMRSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFMTMDQSRKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPQDAADLFTDLENAFQGKIDAAYFETSKYLLDVLNKKYSLLDHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGILETAVRATNAQFDSPEILRRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHYLRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQYYITFEVLECSWDELWNKVQQAQDLDHIIAAHEVFLDTIISRCLLDSDSRALLNQLRAVFDQIIELQNAQDAIYRAALEELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIGEFKESIPKMCSQLRILTHFYQGIVQQFLVLLTTSSDESLRFLSFRLDFNEHYKAREPRLRVSLGTRGRRSSHT
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Sequence:
MTSTTSCEGCEVCKTGEPKYRCPRCSRRTCSLACSRQHKEQENCSGTSGQTTEYIPRGVLKGADTKDETNPLVQRDYNFLIGLNRKVQLLKEGSSQKNKNIVHAGRGDGGHGRVGKPGSVVRRGVRCMLLPKGMQRSLWNKSKWDKSLDTFVWTIEWAVARPGGEQWTHCSHRNQEQSRLLDCIGKAVFDKCAEWLPLAAAGDDGEPLTKASRLQALVGSGLRYYTKQFPAETEGVIDTKRVVELDPQKAVGELFRNKTVIEFPTVYIAASAEDMERLGFRVASDGTTTSSSDSSDTSSSDSSDSSSGDSSSDSDSSSDGEPEENPARLEPAPPPASPSHGGETDSDDGYTPGISLDFLAD
The following text describes a protein:
Function:
Curlin is the structural subunit of the curli fimbriae. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers. Coexpression of cellulose and thin aggregative fimbriae (curli fimbrae or fibers) leads to a hydrophobic network with tightly packed cells embedded in a highly inert matrix that confers cohesion, elasticity and tissue-like properties to colonies.
Miscellaneous:
MISCELLANEOUS: Cellulose production is abolished in E.coli K12 / MG1655 and W3110 due to a premature stop codon in bcsQ.
Subcellular Localization:
Fimbrium. Note=Part of the curli surface structure.
Sequence:
MKNKLLFMMLTILGAPGIAAAAGYDLANSEYNFAVNELSKSSFNQAAIIGQAGTNNSAQLRQGGSKLLAVVAQEGSSNRAKIDQTGDYNLAYIDQAGSANDASISQGAYGNTAMIIQKGSGNKANITQYGTQKTAIVVQRQSQMAIRVTQR
The following text describes a protein:
Function:
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MARYRCCRSQSRSRYYRQRQRSRRRRRRSCQTRRRAMRCCRPRYRPRCRRH
The following text describes a protein:
Function:
May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Sequence:
MKIDDGTLNRYLIKNLQSLTEADPSLLANYVAALLRNNKPKKELQKLCIDQLYDFLGDGTKSFVAKLFHALEDGTVPSSTEEMEPSKPMESGPVVTSTDVVELRTSSPQLERLPSTAVRAFSDEGEDESSDDEDDDRNHKHRRRVTRSRSFDRDGEEEDRGMYRKRGRSTDNGQVLRDNERLANDRRGPGHAMHSERDNNKFDRRLGREHASGRFSSEGGQRGNLRTGPQFRGEGPGPRYDGPNGMMRGGMGRGRGLGSSWPPIDQRFPPPPFSDGSEFAPPLLPPGPPTSGFFPGRGIPGRGVPHTPWPGYGPHPGMGNGPLEHPHQLTGGMQGARGPPPMSAGIGLNMSMGRPRCLDFEERGYCLRGDLCPMEHGANRIVVEDVQSLSKFNLPVSIPSGRGMGIGPVSGPSAGPMLPPGLGMVNRGNRGSRETSSPGMGEDPNMLNGAPPSSVGAEPDLYDPDQPLWNKERPDASAGLRKLSSYQKGSQDPDWDGDLLEKRENQEGSETLDVVRVGRGGSSNGAQGAESGPSVWDRIGPVDRVGNRLDGGPRPVGSPLEGIPSGKPPRKDGGEEMPARGRGVWPVKWNREVEADDESGPRATIANSTPGRGRGVGRSETGLGQRSGEGTSYGSRGTGGRGTSGFGSERAQRTLYVSFIPVLSNRTELLTAHFQKFGHVLDIRIPAHSDRAFVQFSRREDAEAALTAPDAVMGNRFIRLSWANRDSIPDPGDNTTSPAGKVHGKSGHLTTPQTVKAPEKATLNGTANVPAELALSEGGGKAIAANGSSSLPAISGAALKKQEELEKMREVIRRKQESLAQKRVDFRRKLEAKLAKQVPGQGDGSDSEQSAKRQKLDDADENSSGSLKQGVSTTTVSQPSPSQSAPQVPVEHLSSGGLSKSNSGEVLKQSSVTVGVSQPTQPSQRAGRPQNARVNSTNLTYSQVSWGPARFKLDNRTTIFRVLQPFPSAVTDVAVLKEHFSMFGELSTVELEDAEGQKVEGISKLSEINSVRVSFATRRAAERAYATGRWLQGQNLQLVWVTSTNNSTGSGGTAGSSSLVTSRGPSGGPSYMEQEGANGNRYSDRESTKSGQETQDTANDGDVSGEETGYEVSREEKKSSASVPNLEWRRENALQVRASTKVVGRSSSGPAISTESGAETRH
The following text describes a protein:
Function:
Acts as a calcium sensor. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Subcellular Localization:
Cytoplasm. Nucleus. Cell membrane.
Domain:
The N-terminal 16 amino acids are sufficient for the cell membrane targeting of a heterologous protein.
Sequence:
MLAFVKCFSLKRAKHPRGYEDPHVLASETPFTVNEIEALHDLFKKLSTSIINDGLIHKEEFLLALFRNGSMQNLFADRVFYMFDRKRNGVIEFGEFVRSLSIFHPYTPEHEKSAFMFKLFDLHGTGFIEPHELKKMVGALLGETDLELSEESIEAIVEQTMLEVDTNKDGKIDEEEWKELVAKNPSILKNMTLPYLKEVTLAFPSFVLDSEVED
The following text describes a protein:
Function:
Essential protein required for basal thermotolerance, especially during heat-induced chromocentre decondensation, thus regulating transcriptional gene silencing (TGS).
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Note=Localizes to the chromocentre at 23 degrees Celsius, a condensed heterochromatin domain that harbors repetitive elements for which transcription is normally suppressed by transcriptional gene silencing (TGS). Relocates from the chromocenter to the nucleolus in response to heat (30 hours at 37 degrees Celsius or 30 minutes at 44 degrees Celsius), before heat-induced decondensation of chromocenters occurs.
Sequence:
MKKGAKRKGVSKAGRKAAVAETQNDEVIEETTKTTQEESQQHEEEVVDEVKENGEEEEAKGDQEEEEDAKPDSLEEDEENQEDEVKAEEVKEEVEKKPVARRGGKRKRATKKDTEIKDEKKPVPKAKKPRAAKVKEEPVYFEEKRSLEDLWKVAFPVGTEWDQLDALYEFNWDFQNLEEALEEGGKLYGKKVYVFGCTEPQLVPYKGANKIVHVPAVVVIESPFPPSDKIGITSVQREVEEIIPMKKMKMDWLPYIPIEKRDRQVDKMNSQIFTLGCTQRRSALRHMKEDQLKKFEYCLPYFYQPFKEDELEQSTEVQIMFPSEPPVVCEFDWEFDELQEFVDKLVEEEALPAEQADEFKEYVKEQVRAAKKANREAKDARKKAIEEMSEDTKQAFQKMKFYKFYPQPSPDTPDVSGVQSPFINRYYGKAHEVL
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKSTKKESTHSKEESQTQAGNSEARKSGPSTKKAGEKTAEPEKATAGSGTEKSPEAACREENELLKDQLFRLAADFDNFKKRTARQMEENRKAVLEQVLLDFVEVTDNFERALKSAQTAEDMGSIVSGIEQLSKQFFSILQKYGLERIKCEKAGEFDPHRHEAVQHIETSEVPDNTIVDVYKPGYSLNEKVIRPALVSVARNPDETEK
The following text describes a protein:
Function:
Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination. During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint (By similarity).
Subcellular Localization:
Nucleus. Note=Brca2 and spn-A become recruited to nuclear foci after DNA damage.
Sequence:
MDQNGASGSRPNRLSQGKEAYACERSATVSAAADRSNIINEMAKICEADRQTSAIARRTQVHERLAVANSDFVAVEDLILAYAEPTPEDQVEMIMRDFCSSPTYEEDEDEPSYESEPWFRFRNKRIRTYSRKRDPKSYMAVRTEKSSGTSGLSVQRDLNTSSTSVACDFDAASSQKIHEVLLNLSQYFSATAKASSPTPVPSQIDLPTEARQDSGDECFNAEVENLRDDLLQNGFTFEASIYDNEHEQEDSGKFNVCSDADSTPKKTDVEIAEHKKHLKGPTQAEHVGKEENTNFILEGIPLSEWLTPMEPPKISKDVIKNIPDKKVKLEPSSQKEQKSSKDSNESKIRAASCDITKKNEGTTVLDQPNAAQQENLSNDGDLLEEFLFNEWHPMQCSNGPSTSNDAIKVPKEEINSIKRNDEEQPEKETPNKSRSTSSHQLSFRKTFLKFIEISGEMKIKGEKFVEKVVSGLHHPSHKCNLRTEEYSDNHSQVMESTQRVEFKSALSKPIELLDEKETYDMLAKVEVGEINGKCSPLNNETIAEPEFCGFRTASNKAIPISEKMKIKTAEFMAEFQSKETNHQNDYLVNQPNDNSTSVGRDTAFKKSIEISEEMPTKASKLVVVDTTLGEPHQPKIDPVCSDLNESQFFGFRTASNKAIEITEAMEKRGAMFLAQSRATDQQAEWQPSDFPDIPHTSPKNEIHSINVENTKAVHTKTASETEFFGFRTASNKGIVISENTKKKVAQFMSEFQAADASTDSNKPIVISEESRNIAAKFVDEAATEDSPNKPTFCNVQSQENPLDIEHFKHDLFVERSAKEEHPLCSQPLVRTPRRSQEIHSSLSQLAGQSPLDQATKKSVIARRNLLSLKRKRKIVSSTETSTSCASPAMERFAPKPSSTSTPLADRDLNRSKDCAKNRQDAEDMSPICMQPKKSRRLGLSRSRY
The following text describes a protein:
Function:
Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKVGFALVLLWSLPITNVLAELPQPQNLTLLTLNTQYVLTWDWDQTTTGNSVSFTVEYMAKYKMKMKKKNWSRVCERTTRTRCDLTGSDLHYLGMYVLRVRASADGVNSDWVNKDFCPDIDASLGPPSRVELAPVGNLLDVTISDPLTSTQHSMKEHVLFLYYRILYWSRSDDPQGLKPKVLDSSNNLVTLPELEAWTWYCVMIQSRYDYYNKTSSYTEPQCMQTEGDTPYGQIFLYFLVSMMVCFLLVLLSSYAFFRFYRGLKNTFYPSIQLPAHIQEYLCDSSPGSDMPRLITADSEAELCCDKLTICPEVVLLEIHVPPPLTAPPSELEQDSGRRIRQDSGDSGIYSTEGGSAQQGRSGGEPIRRDQEVDSWQTLEQVKMEEMGRELADERDLDEGVVDICV
The following text describes a protein:
Function:
Functions in endoplasmic reticulum to Golgi vesicle-mediated transport and regulates the proper organization of the endoplasmic reticulum and the Golgi (By similarity). Plays a key role in targeting to neuronal dendrites receptors such as HTR1A (By similarity). Plays also a role in primary cilium and sperm flagellum assembly probably through protein transport to these compartments (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note=Shuttles between the endoplasmic reticulum, the intermediate compartment and the Golgi apparatus.
Sequence:
MNQESSFRAPPKRRVRGPNPNISTPHQLFDDTSGGPVPHGGEYPNHSSPALGIPAQAFLSEPMSNFAMAYGSSLASQGKEMMDKNIDRIIPVSKIKYYFAVDTVYVGKKIGLLMFPYMHQDWEVRYQQDTPVAPRFDINAPDLYIPVMAFITYILVAGLALGTQSRFSPEILGMQASSALAWLIVEVLAILLSLYLVTVNTDLTTVDLVAFSGYKYVGMISGVISGLLFGKTGYYVVLSWCGISVVFFMIRTLRLKILSEAAAEGVLVRGARNQLRMYLTMAIAAVQPIFMYWLTYHLVR
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Subcellular Localization:
Cytoplasm.
Sequence:
MVLLESEQFLTELTRLFQKCRTSGSVYITLKKCKQREGSRAMLPGCPVSGSHRSLSAADRRLPLPSVTLYWAHSGLRAWKMMGIVAGAVPSAEPPRLLLVSSKEVNKFQMAYSNLLRANMDGLKKRDKKNKTKKTKAAAAAAAAAVAAAAAPAAAATTATPATPAATAATAAQ
The following text describes a protein:
Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Sequence:
MTTAAEHPIYIDQGNVGDNEVVVHSEQTVQSASIIFEEDADSRDSGVSMTSCSGDKKDIMESSGIVDFSKTEPRLALSDCSNFVAKMKRNSSVSSSRSSSLFLCSIFSYNYDTPTGRTKRTIFDTDTYDQSMYEKKSLLDRTLDKHRKRSSSSMSPTFTLMDRKRSRNLSVAAPQSEKICRYNGSFNVPNCNDPFGDDDDDDVFLQQNQSSSQHFNTSASTFAPPAPRTATSLWDLAPPTPLERKSSDTSANGSFLERPKQMLRAMSVGVIDHDLPATLEVKYTLPAVDKPQKASQAFRSISAKTLLSEFQRLGDDFNKTYMIVDCRFPFEYKGGHVKGAINVFRHDKIKATFFPEDLTFCSFPKRIPIFYCEFSQKRGPAMAHAVRSIDRVRNELRYPHVEYPEMYLLDYGYKSLWNLTECRQICEPQSYIPMNHSLYSSEFRSARLERHHSMASLKPNGETGHREEKKKRCTRSAIRRNNSTLSLLSKSSSALNSGFSTENIFHELENECKCPKWVSAFDINSIGSEVDLDQELLNHSENDAPVSDTSSVIDLNVDRVVQLGIKVITPDFGMHDIPSSSSGPSTGHHVPLSLNANDLDTPCAALDFSAISDTD