lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Note=Localizes at the cell poles.
Domain:
The membrane-extrinsic domain forms parallel contacts with at least one other TatB protein.
Sequence:
MFDIGFSELLLVFIIGLVVLGPQRLPVAVKTVAGWIRALRSLATTVQNELTQELKLQEFQDSLKKVEKASLTNLTPELKASMDELRQAAESMKRSYVANDPEKASDEAHTIHNPVVKDNEAAHEGVTPAAAQTQASSPEQKPETTPEPVVKPAADAEPKTAAPSPSSSDKP
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
Subcellular Localization:
Nucleus.
Sequence:
MTSGQDAEEAAELMATMRAEHVPMKSWYNNPSHIGLHSKYGDFPLFWQDLRGWDGWKEVRREYLRFTEGGGRSLESAQAQATDGIDADGGRKKRSRWADEGEEGAADADGTSASAAALAASSSGPPERKRKSRWGRGRDETPKPSINAAATTQPPPIQDPVMAALGLSSTPSTATLSTTAQSLLPSNLSSSVPEHHRAELNTLQERLRKANSRLTNLEAEAAKIDALPRGHPDRSPSPPPIYGPDGTRKNTRANRWRETYTEERAVCLERIMELVPTMRPPGFLTKRKRSRKIHIPVEDHPTYNFIGLIIGPRGKTQKEMENKTGCKIAIRGKGSVKEGAKGRRNGQPMEGDDEPLHVVITGDDPAAIDAAAEMVTSMLVVIDDEKNIHKQNQLRELALLNGTLKDEEWCITCGEKGHKNYECPKRFALSSKSAATLQIKCAICGDTSHPTRDCRMKPSAAAEEGMANQIKKERELDSDYSAFMAELDGRPVKEEAGEDCGGKESGGTAVSTASVPPRESVLTIIQPARVVKVGEETVEASVVVPPVASLPAANSILTIIQPARVVKVGEEATTDTTGAAAAVQPIASGITTISSTVPSGVATISSTFPTSSSAAHPIASGVTTISSATLPPAPTTSLPLPPSGEPPASLTSGTGVIKAPDGAMVATGTTLPLPPPPPPPAAVGGQFPPPQMVYPGQQWPGVPPPPPPCAYPNQYQQGGYHQPQYGQQPPQQQQWGAGGYNAANGQGNNGAAWNPNGYYAGAGDANGAGGFNWWDSSDS
The following text describes a protein:
Function:
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. May be required to embody the molecular ruler of the complex.
Miscellaneous:
MISCELLANEOUS: The tRNA splicing endonuclease complex is present with 100 molecules/cell; MISCELLANEOUS: Present with 531 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=The tRNA splicing endonuclease complex is predominantly associated with the outer membrane of mitochondria, suggesting that tRNA splicing mainly takes place on the mitochondrial surface.
Sequence:
MQFAGKKTDQVTTSNPGFEEEEEEEEELQQDWSQLASLVSKNAALSLPKRGEKDYEPDGTNLQDLLLYNASKAMFDTISDSIRGTTVKSEVRGYYVPHKHQAVLLKPKGSFMQTMGRADSTGELWLDFHEFVYLAERGTILPYYRLEAGSNKSSKHETEILLSMEDLYSLFSSQQEMDQYFVFAHLKRLGFILKPSNQEAAVKTSFFPLKKQRSNLQAITWRLLSLFKIQELSLFSGFFYSKWNFFFRKYTTSPQLYQGLNRLVRSVAVPKNKKELLDAQSDREFQKVKDIPLTFKVWKPHSNFKKRDPGLPDFQVFVYNKNDDLQHFPTYKELRSMFSSLDYKFEFLSEIEDDDDWETNSYVEDIPRKEYIHKRSAKSQTEKSESSMKASFQKKTAQSSTKKKRKAYPPHIQQNRRLKTGYRSFIIAIMDNGLISFVKMSEADFGSESVWYTPNTQKKVDQRWKKH
The following text describes a protein:
Function:
Involved in the biogenesis of cilia. Required for the recruitment of PLK1 to centrosomes and S phase progression.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasmic granule.
Sequence:
MEEREEGEVRRESFNAPEATTMSKHGSLKDAMRQVLETKGVIDHVKAELRAAIFHSLQESNSQGDDIESARPPIPPENLLLNELIKDYMAFNGMEHSLSVFKAESGAGKEATSAIMPRAILASQLGLTGAPASVPLLYAMLHELRICSENS
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MERDFLGLNGDAAVALQVKERSRGFQDSSDSISIFTVNPAVQWPYANETAALLQVQSPNAADECKLKRTTFDHFSFPGLHINPKCFPVVSSQTLSNLGRQGLKQHLTSSSATIASDCPLVSHYSTPLAGSGGATAEEDHSVRSTFLGDRSSWNTSKSFSSPSQLTIFYGGSVIVYDNVSSDMAREIMLLASSRNHAAAASTPVSLSPATTTSPRAIPLSRKASLARFVEKRKQRMINYKPYPFCDKRKDANSSAAFTRASHENSDSDSGPSSHRCQ
The following text describes a protein:
Function:
Putative metalloprotease playing a role in the process of LR patterning.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MTVSFSMFQIYRLVWLSFMTSMCLSACIHDSVLQETPVVSSNIISSRVPRLFPRSTSSDYFQPLRVTPWYLLGENAFISQGQIRQLKIALQEVTQMLSSTLSVHRSEGSLLLNRDISRFCRSVWRAPNDNKCAYMQTSYQGEKCLDVTIPDFHLQGVKVWSDLEKEPRTVIEDGAGVPDTDFLLYVQVAQTQKCAAQPSVIAYASYCQQDPTGRPLAGVIVFCTDHLREEEYNQRHIIQVALHELLHTLGFSSSLYASWLDCSLAEYGEACSSRTRVTNTDENGQFRIYTPTVMQKMGEHLGVEGVGAPLENKGFPNLASSHWESRFFQGSIMTALLSPPHLTHLDPITLAAFTDMGWYKVNATIKSQLMWGKGAGRYFGLPTTCQDSSTGFFCTGSKLGCHHLHLDKGNCSTDSYLEGCHIYSPLIHGGECWRHQNSGDPDEIFHAQSRCFYSNLTKGASPNQEFRGRCYLHQCLGENHFQVKVHESEWTDCPAGAWIQVAGYEGFIQCPSGCLCLGFQTPHVATLTPTYVTGQITTVKENNVYPTEGIVQFRVQVEVSQRHKWTSEIKSFLLDEVLGVIAQKAGVQRCFLQSHMKEDLDLSFAIVGKWSTDCPPTPEADTAAFSLLTLNQDGAPYIIYNSSYFSTVSIRFIDSDPPALYVSHMLYSYVIGGGCCAVCGAAIIFALFWYKLRRQFLRVGSSYPPETSNHERPQIPADLV
The following text describes a protein:
Function:
Regulates membrane-cell wall junctions and localized cell wall deposition. Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSTSEAATVIPVYDVAPGQGAPSKAPAAAAVPPAAAPAAPPTTAPRKFPMRFFRRSDRGSRCMAFLDFLLRIAAFGPALAAAIATGTSDETLSVFTEFFQFRARFDDFPAFLFLMVASAIAAGYLLLSLPFSAVVVLRPQTTVLRLLLLVCDTIMLGLLTAGAAAAAAIVDLAHSGNERANWVPICMQFHGFCRRTSGAVVASFLSVFIFVLLVVLAAFSIRKR
The following text describes a protein:
Function:
Required for tapetum and pollen development.
Miscellaneous:
MISCELLANEOUS: Plants expressing an RTS antisense construct display interruption of tapetal development, resulting in deformed non-viable pollen.
Sequence:
MVRVAAAAAVLVLAAAAAAAAAMAAEPPTDDGAVRVAAGLTKCVSGCGSKVTSCLLGCYGGGGGAAAAATAMPFCVIGCTSDVLSCATGCSTSL
The following text describes a protein:
Function:
Dual-function toxin that inhibits trypsin at a molar ratio of 1:1 (Ki=107 nM) and inhibits mKv1.3/KCNA3 potassium channels (IC(50)=6.2 nM, and inhibits 80% of currents at 1 uM).
Miscellaneous:
MISCELLANEOUS: Negative results: has no effect on chymotrypsin, nor elastase, nor the KCa1.1/KCNMA1 potassium channel. Shows weak inhibitory activity against mKv1.1/KCNA1 (1 uM inhibits less than 50% of currents), hKv1.2/KCNA2 (1 uM inhibits less than 50% of currents), and hKCa2.3/KCNN3.
Subcellular Localization:
Secreted.
Sequence:
MIIFYGLFSILVLTSINIAEAGHHNRVNCLLPPKTGPCKGSFARYYFDIETGSCKAFIYGGCEGNSNNFSEKHHCEKRCRGFRKFGGK
The following text describes a protein:
Function:
Promotes the proteasomal degradation of host EIF2AK2/PKR but is unable to suppress host general transcription. Prevents the establishment of the host antiviral state by interfering with beta interferon (IFN-beta) production. Interacts with host RIGI and targets it for proteasomal degradation, thereby inhibiting RIGI-mediated signaling pathway.
Sequence:
MQSRAVILKYRSGSGHKRSLPRFYIDCDLDTFDFEKDCSLIENEFPIYINNYKVVYKSKPTLSHFLIEKEFPAVLGPGMISAVRTRLYEPTMRELYQESIHQLKRSNKKYLLSALRWPTGIPTLEFIDYYFEELLFLSEFDPGSIQRYLKLLVKASGLYNSTNEEQIVEIHRRVLIEGKKHGLTAFDLPGNDILGDICVVQAARVTRLVAKTFSKMTRDTHLMIYFSISPVELVLSKLDKKGDKRAKAKGLMSMSAARSYDYFMRTDLGFRETALSTFWAKDWPTPQETILSDKRCLKEDMRVTKWLPSPPHYPPL
The following text describes a protein:
Function:
Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.
Sequence:
MIHVYTGDGKGKTTAAVGLAIRAIGNGFRVLFVQFIKGVHTGEIEIFQKFPELIEIYRCSTGFVYKTPEESQMETVKECVKEIEKKLEKNTYDMVVFDELSVALSIGLLSREDVERLIQLSKKAELIITGRNAPDWLIERADLVTEMKKIKHYFDRGIKARKGIEY
The following text describes a protein:
Function:
Non-reducing polyketide synthase; part of the pkg gene cluster that mediates the biosynthesis of dihydrocitreoisocoumarin and 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin. The non-reducing polyketide synthase pkgA performs the condensation of one acetyl-CoA starter unit with 6 and 5 malonyl-CoA units, respectively. As pkgA lacks a releasing domain, the thioesterase pkgB is necessary to break the thioester bond and release dihydrocitreoisocoumarin and 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin from pkgA.
Domain:
Multidomain protein; including a starter unit:ACP transacylase (SAT) that selects the starter unit; a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a product template (PT) domain that controls the immediate cyclization regioselectivity of the reactive polyketide backbone; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm.
Sequence:
MTPSASPSPSPNPGDANVKVDADSPNDFILFSHELPSGDIQDLIRRLHRYGTLPGYPHLARFLQECALLLRTEIQKLPRALRDSVPPFHDVVTLASHWDRLKSGPLSGAWDGPFLCLYEIAMLIGHHETHQLSYRRPACLVGISVGLFSAAAVAVSKSISDLVSYGAESVRTAFAFCVHVQRVSQELEPTMTEQAASVSWATVVIGVPADTIQVELDRFNHLKESESPGANARPLTGVSISHVDQTSVGVTGPPSRLKQLFRQSELLRSSRHSALPISGGLCHVPNVYDDEDVRAILEMAEVWEKWGTRALQVPLISPFTGSPFLCPDAYHLIEAICTEALTKQLYFDKLAGGVVTQLNGLSCQVLHYGASLMSDTIIDDVTSQLSPCDTARQCLVDWALRDAFDQLPGGPTPPRDAKLAVVGMACRMPGGADTPDHFWELLMNGVDTHTTVPPDRFDLDAHFDPSGEKENTTTKGSQSNRPLSRQAEQTDPMQRLALVTAYEALEMAGFVPNRTPSSHLSRVGTYYGQASDDYREVNAGQKIGTYGIPGTERGFGNGRINYFFNFQGPSFNIDTACSSGLAAVQAACSALWAGEADTVVAGGLNVITSPDIYCMLSKGHFLSKTGQCKVWDIGADGYCRADGIGSVVIKRLDDALADNDVILACISAGATNHSAESISITQPHAAAQRENYRQVMDRAGVSPLDVSFVELHGTGTQVGDAVESESVLSFFAPLGRRSHPDKRLHLGAVKSNIGHGEAAAGIASLIKVLLMYRNNTIPRHIGIRTAMNPVVAQHLANRNAGILSENHPWLAATASKKRYAIVNSFGAHGGNTTLLLEDAPSQHSQRYKNHSRRVVASSEVVCTSAKSKASLRANIRALLAYLDTHQETDLRDLAYTTSARRMHHHIRIASSVTSTAQLRSFLQAAADDVDAYAKHIATATKRTAVFAFSGQGCLYHGAAAHLFEQAPLFRNQVLQLDRIVRRLGFPSILVTVAGDAASVYDSARCPHRESTPSSDASHDSNTNRTSTAPAVDSPLIAQLALVVIQIALVQYWGLLGIKPSVVIGHSLGEYAALVAASVLSVADALFLVGKRAELMLAVCEPGSHAMLSVRGASVDRIEELCRESEKRYPFEVSCVNGLTDLVVTGLRGDMASLRDLLQGSGLKCVLLDIPFAFHSKQMSPILEDFENAAQQITFQEPAVPVISPLLGKCISEANVINGKYLARATREPVDFVAALDSAWADGTVNDKSIWIDIGPHPVCTSFASNHYGKAATQSFASLRRGDETLSTLTATLAALHCLGLPVDWNEYYDLRENPARLLHLDSYQWNYKNYWIPYEGSWTLDKAHAGQNNKTKDDNSAVTPAFFTSSVQQIIFEEYDESMGRMEALSDLHHPDLQGAADGHKIHGRSVVTGSIWADITLTVGEYLYKQMVPGGKMPHMNVKGMEVLEAQVLHPDMSQFIQIEGVLDLPRQQTAVRLYAASANGTRNTDKPFASATVCYEEAQDWQDQWQMTSHLVAARANSFWEMAAGGSDDNARPAGKGGPRVNNFFRSIAYQLFANVVDYGARYRGMQRVALSEDTLEATADIVLDKDRHGTWHTPPHWIDSAFQLAGFVMNSFGVQGDGKISGSSRDFFYITPGWRHFRLLERLEPGPEATYRSFVRMFPVGSEPGAYSGDIYLHRGKRLVGVCAGIKFKAVPRALMPVLFPRIEPQAGKRRNQAQTAENRLVKGKGNCEYTHTVFQEPKSRTPAYDVTKSQPHAEHCDISISQKTQPVAAVPVTQPALPAKERGEQNQGQSQSQNAQATACLSLISDETGLDLDDLTGEAAFADLGVDSLMSLALSAKIRAELGIDVQSSIFLECPTVQDLVTWLSK
The following text describes a protein:
Function:
Constitutive protein of the cell wall. Antigen target of host humoral immune response.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MRFHIPFLLAIFAIAQASPVAAPHELVRRDGAAVIDAVNIVTESMIALNNTVTAYKGGFLGTFTALKIEFQSIALSNDLRDAISTTKSSANFTEEESLNVSGAFLELQPNIDSTLDNIVSKKPQFDNGLLGIGSLAFLVRSNLEKQKELAGELGDAVVLKLTKTYAVIAPLLNAQIQAKFEEAIAAFE
The following text describes a protein:
Function:
Plays an essential role in the virus replication cycle by acting as a viroporin. Creates a pore in the host endoplasmic reticulum and as a consequence releases Ca(2+) in the cytoplasm of infected cell. In turn, high levels of cytoplasmic calcium trigger membrane trafficking and transport of viral ER-associated proteins to viroplasms, sites of viral genome replication and immature particle assembly; The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells. Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability. Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea. To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.
Subcellular Localization:
Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein. Host membrane, host caveola; Single-pass type III membrane protein. Secreted. Note=NSP4 also localizes in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus-infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain.
Domain:
Binds 1 calcium ion per tetramer.
Sequence:
MEKLTDLNYTLSVITLMNNTLHTILEDPGMAYFPYIASVLTVLFALHKASIPTMKIALKTSKCSYKVVKYCIVTIFNTLLKLAGYKEQITTKDEIEKQMDRVVKEMRRQLEMIDKLTTREIEQVELLKRIYDKLTVQTTGEIDMTKEINQKNVRTLEEWESGKNPYEPREVTAAM
The following text describes a protein:
Function:
Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.
Subcellular Localization:
Mitochondrion.
Sequence:
MSKLPKASLSLKQFMLRQEVLKLYREIFRTIRQVPDKNSQLELKSWARHDFQTNRHQSDEVAIKMLLQHGRRSLTELRTSLQLSGVSEGK
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MSMLRCIGYNIGSYFYNSVSSKRLIKLQPFTQKNVVHILGNCYYPETNENLNHLTFNDANIKIHDLIVATYRQKYSYLGNTYLSSDAGWGCAIRATQMMIVNALVIFKDQMQQIVDYNSFEHQQNKSQAKELIYDRISSLLSIHNIYIQQVIKTHNPKGTNFLPPSVCCIAISSLLQEWDKKPFNCITCLNHIPSCSCPTLYLIPRIITFTEHQLILDSLALSQSRGFVGGIGESAIFVFGCQGTTLFFLDPHYVQNAGDFGYFNPPTYQIDISLISSSVVFAFMCYEENECEQLRTIFGMGKVPIVAREFTSTKEIDGVEVLDF
The following text describes a protein:
Function:
Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring approximate 15 minutes before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins bind asymmetrically to the septin collar. The septin assembly is regulated by protein kinases GIN4 and/or CLA4. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.
Miscellaneous:
MISCELLANEOUS: Present with 1170 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Peripheral membrane protein. Bud neck. Note=Present at the bud neck during cell division. Probably interacts with phosphoinosides such as phosphatidylinositol 4-phosphate or phosphatidylinositol 5-phosphate.
Sequence:
MSAATATAAPVPPPVGISNLPNQRYKIVNEEGGTFTVMLCGESGLGKTTFINTLFQTVLKRADGQQHRQEPIRKTVEIDITRALLEEKHFELRVNVIDTPGFGDNVNNNKAWQPLVDFIDDQHDSYMRQEQQPYRTKKFDLRVHAVLYFIRPTGHGLKPIDIETMKRLSTRANLIPVIAKADTLTAQELQQFKSRIRQVIEAQEIRIFTPPLDADSKEDAKSGSNPDSAAVEHARQLIEAMPFAIVGSEKKFDNGQGTQVVARKYPWGLVEIENDSHCDFRKLRALLLRTYLLDLISTTQEMHYETYRRLRLEGHENTGEGNEDFTLPAIAPARKLSHNPRYKEEENALKKYFTDQVKAEEQRFRQWEQNIVNERIRLNGDLEEIQGKVKKLEEQVKSLQVKKSHLK
The following text describes a protein:
Function:
Enantio-specific polyphenol oxidase involved in aromatic ring hydroxylation. Involved in the biosynthesis of the creosote bush 8-8' linked lignans. Has a strong preference for the 3' position of (+)-larreatricin.
Subcellular Localization:
Plastid, chloroplast thylakoid lumen.
Sequence:
MASLSSQSKLLATPYSFPYHTKPSRVSLRRVSCKASNDNKDKPNDQEKTFSIDRRNMLIGLGGLYGASNVFPSNQSTLAAPIQPPVLPDSCHPPEDLAEGVNVLCCPPDVKDPIDFQMPSNPSRLRIRPAAHLADPTYIEKYKKALAAMKALPQNDPRSFYQQANIHCAYCNGAYDQVGFPDVNIQVHHSWLFLPFHRWYLYFYERILGSLIDDPTFAIPFWNWDAPKGMHMPHMFIDPNSPLYDAKRNPAHFPDTIVDLDFSSGEAPSHNPRQIGNNLSIMYKQVVRAKKARLFHGRPLQAGSFPDESGDGSLEGTPHGNIHLWSGDPRQSNFENMGNFYSAGRDPLFYAHHANVDRMWYIWKNSLGRKDYKKKDWLNAGFLLFDENAQPVRVYVRDALDERKLGYAYQEVDIPWINSKPKPRKANPWPNRLRSKATTTTKLINKFPLTLDSTVSFEVKRPKKSRSKSEKEDEEEVLVIEKIKHEPQFPLKFDVYINDEDEDPSAADQTEFAGSFVNVPHFHRHGDKKDKRQTTNLSIGISEVLDELDVDGDDSIVVTLVPRVGSGQITIGGAKIEFVRDEED
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MAMAHDDVRIIYGHKVIGTYSTNQEENYINDNRNRRFYLAPGDGFKLSYGEEFNNFTDRKGESNLVGGRYRWMEDHRQDLIDNQIWDIEQSRLNVDFVSHRGVLSSILQMGGKKFLEIDLAVTLYKGTYHLRSKGLGRADPQAQDIQKIAASSKILLQFVTSKDGLNQDEPPPDDHTPGEPAPAKGNEYFYTLMTVNCGNHRLLLSGDIQAEKRIAPDEPPPALPDPTNCMNVRSRETHQDIQPMKALAWWASNVIAGIPEICCGLRNDKKNTIKKIEPIKTSDLATSGYTENRWDPEVCIRKMESLLSQIKELVPEDDPNSIKQAVLIIRPVDGGPGVEDRMRNRTFEIRERLEEDRFVEEHELRCIFEGNE
The following text describes a protein:
Function:
Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Endosome, multivesicular body membrane; Single-pass type II membrane protein. Prevacuolar compartment membrane; Single-pass type II membrane protein. Note=From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).
Sequence:
MYIPGPLRLSSYLLPFLSSPSPPAQSSPDTRTISFKPVHAHGHAFVDNASTPTLLFLDQSPSASLYAHDYPIGAFGDDYVLPRLTSDVLEIRTRKKLIRRPKVRPPRIISWAQSYRAQALHFNGINNNNDNSNKSISLPESWLAPDLANPSDEWSDVEVTVPDLTDRQTVITLAKMSSNAYVTPGGAGWYTLNDWNASMPFGWEPDADGLRGHVFADEKNETVIISIKGTSAGVLGSGGPTAKNDKFNDNLLFSCCCARVDFSWTPVCDCYAGGYKCGQTCLEDALVSESVYATVGTNLYNNITYMYPNATIWLTGHSLGGAVSSLIGLSFGAPAVTYESPGELLPASRLHLPLPPGMPANLSGITHVYHTADPIAMGVCNGPYSSCYAAGFAMESKCHTGETILYDTVRVKGWSVDVRTHRIEEVIDKVLADPWPEEGEGKSGVWEKAVEGWYRAADRVRAALDESVVRDDVNVWWGWGRRGPKRQPGGEDPGWRKHGGVPKPVSEEDCVDCYKWEFGEWN
The following text describes a protein:
Function:
E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection. In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity. Also plays a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination. Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1.
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Adopts a filamentous distribution in the cell cytoplasm where it strongly colocalizes with stable microtubules.
Domain:
The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity and for nuclear localization and aggregation.
Sequence:
MEVSTNPSSNIDPGDYVEMNDSITHLPSKVVIQDITMELHCPLCNDWFRDPLMLSCGHNFCEACIQDFWRLQAKETFCPECKMLCQYNNCTFNPVLDKLVEKIKKLPLLKGHPQCPEHGENLKLFSKPDGKLICFQCKDARLSVGQSKEFLQISDAVHFFTEELAIQQGQLETTLKELQTLRNMQKEAIAAHKENKLHLQQHVSMEFLKLHQFLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVLATRELISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVWHGDIKKIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNAKTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHILHPQ
The following text describes a protein:
Function:
Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDRRLNITPETLNQLLKEHNMTRLQFIAAYGLKPLVYIPELPLSAKVIFLVLYIIIFILALFGNSLVVYIIIRKKAMRTVTNIFICSMACSDLLVTFFCIPFTLLQNISSEWLGGRFVCKMVPFIQTTAVVASTLTMTCIAVERYQGIVHPLKMKRQYTNIRAYKMLGCVWSVAIVVGSPMLYVQTLEVKYDLLYNLYHVCCLESWSDVGLRRAYAIFILVALFLVPLAAMLLLYSRIGYELWIKKRVGDCSVLNTLSRNEMAKITRKKKRAVMMMVIVVLFFTACWAPFHVVHILFEYNNLEDQYDDVTVKMIVAIVQAVGFFNSFNNPVVYTFMNENFKKSLVAILFCHFRAQEPVEPADKRDSQQSERPKGGATMFFTRRDGRSGQSHLSAENLELRLCEQFPSARLESVAYPLVNSHKDLLPNGQSA
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MEAPPVTMMPVTGGTINMMEYLLQGSVLDHSLESLIHRLRGLCDNMEPETFLDHEMVFLLKGQQASPFVLRARRSMDKTGAPWHLRYLGQPEMGDKNRHTLVRNCVDIATSENLTDFLMEMGFRMDHEFVAKGHLFRKGIMKIVVYKIFRILIPGNTDSTEALSLSYLVELSVVAPAGQDMVSDDMRNFAEQLKPLVHLEKIDPKRLM