lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MTPAAAVQTRLAAVMESLVHAAVAELKKLLDDSRAPGEESREEVVQFALVMETLGNEALGKILNIVQEAEPLQALKSGRKPQISVLNILNNTHVELEHSYGVRHQTDNAGKASQADVEEGAMEAPFVPAVTVKDKRGTIDLAAIAERAASSPQPPAHESSNPQDSNVHEAWSTLSCSVCGKSFATQSNLKSHFLIHTGEKPFACSVCGRAFRQRHSMQSHMCTHSGERPFQCSDCGKSFYKKWRLKMHAISHTGEKPHSCDVCGRRFNLLQNLHRHALMHTGEKLFICSECGKGFTRAVTLRTHQFIHTGQKPLKCEQCPKTFRHAVNLRNHLRIHSGERPFACELCGKSFRQAGQLKIHRRVHTGERPFSCRECGKSFTQQSSLISHGRTHSTERPFACSSCNKTFNNANSLKLHVRVHTGEKPYACDLCDKSFSQGSHLRTHQRHVHSGGKQYICDRCGKRYADQRNLKLHKCGFS
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
Subcellular Localization:
Nucleus.
Sequence:
MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKKSAVRPRRSEKSLKTREDIVALFPVPEGAPSVHHPLLTSSWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRKAV
The following text describes a protein:
Function:
May play a role in filopodium movement.
Subcellular Localization:
Cell projection, cilium, flagellum.
Sequence:
MNKSRAPPDARIQKMRELEERLANLKADRKVEQKMVAVAEFEARTTKKIVGNLVQQRYDALKARAEADLNARRQRLADKLDAEDLAMRQELLASKKTPEQRRAELAERARALAATREAERQALASTLYEKAFIQSCDVLRDENSKRILYRTIEERNAQIEHKMAQRIMEAEEKRMWHEMSEVERQKMEQRYLDDKRRDREKREEVLRILDEQVRQVNARRAEASMLRRAEIAELNATWRQMAADQEAADVQERENMKKLAAELQEFNRIKQMEISEAERSERELDLKILQEALSKEAADEAAELAFRERRREEMRRYREQLALMMEKEREETAERDALILKAQLEQEAKRDAELAARDEARRQLMAQVDAIRQIQIQEKLAKRLERAEEKAFERAQMAEEVAKAESDAAAKDAADRKAGIQRRLELQTMMVAKAHMKAAELDEKLAEGEATKRVEDQFKAKVNQTLSSTDPPVWHGRRKFDW
The following text describes a protein:
Function:
ATPase required during meiosis for the formation of crossover recombination intermediates. Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (By similarity). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (By similarity). Plays a key role in homologous recombination and crossing-over in meiotic prophase I in male and female germ cells. Required for proper synaptonemal complex assembly and homologous chromosome pairing. Required for recruitment of TEX11 and MSH4 to recombination intermediates.
Subcellular Localization:
Chromosome. Note=Localizes to meiotic chromosomes; associates with mid-stage meiotic recombination intermediates. Localization requires meiotic double-strand breaks (DSBs) recombination intermediates catalyzed by DMC1.
Sequence:
MALNGRTMFPAFKYYAIDYLQEDIIKERLYRDALLLQIPSCLNQDKNIIDDKYRTPWTRAIPVQEMEDNSVLEQWRTRFCVEGVPEKKTVTGVMINGTFEEIVPSSNPNSPPGIENDKLFPSKDYVDDFIPVKCSLYYPGVKAEHQGLLIDEEMIFMNKAMDNHLPTVNGLLSRLKLYLVKDPFLDFKEELSGKDNFTEYFSVQECSEPFVRDFHMAEETFCKKKLPSVFPSGFKSLISTNPKQEILILPPSKLKKPLNSIPKIMDSVDESECFKGDITSKHEFDTEDIKCNSTENLTFASLCEPECSEPGDLEMPPTHLILPRQHSAVSSLHMGFQTFPFSATCKINLLSAGESANKYCMLWQLGGCRNSWVSFLLTVPRFQEPSSQYSLADMRNIFSVKGDSLVINPAKAKGWRQARLHPIMAETLAHLKAYLCHNGLSSQETKLEIFLPTKVFQLESWLELKSRPLPIVPISEKSTDVHQLHPQKRPIPSSEKEVPHLCLSGESISVKKSKVEANPKNDQEPEARIMQKPENSCVGLGCSSQVPSAESASSSQIQASYDKKQDDLDLLSEFIILRSKHQTFPSEADVDVKSHDHDQNNEFQDKEKYSLTLQEESLVASNSKAPEERCEERTDGVIEIPASDTQCQAYCLLEATANPILKELVCLCTYPAANWKFATVNFDQTRFFLKEQEKKINDATHPDKNDDRKMTFRHAALLHLLITIRDVLLTCNLDTALGYLSNAKDIYKSVLDSRLDNIWRQLKILQFIKEKRPKSNYKIQELQCQILSRLQNQQQMKVLIIIRMDSDGEKHLLIKTLKKIEGLTMTVLRSNDRKKILETTSILKGTNACVVVHNHSIGADFPWSSFSLVVEYNHVGHSCWAEHCQLLDIPFLAFKVAVPDTALQRDALLDGFGGFLLKIPIPYVFFASEGLLNTPEILRLLESNYNITLVERCCCGSLKLFGSTECYVVVTVDEHTAIVVQDLEELHHEKASDNIIMRLMALSFQYSCCWIILYSKETLNSQYHLTEETLRHLAQVYAALVSSGLKSEELDVKLIIAPGVEETALIIRQIADHNLMTSTRDPHEWLDKSWVEVSPSKEEMSLLDFPCINPLVAQLMLHRAPSLHWLLIATPAELQELLPQVPGKVLKHFCSITSLFKISSPSMTKSSQISSLQEDMNQTDLFISQSSAPIIQEQEEYYPYEDSEGTSSSPVELRATPCMLPSAAPHSQRGCWEDPSCGPDPVQNNPSLMNAESKKVTWPSVPSWSDSESDVFSLARTQVSCEPIMTLTDSQRRGTNGFVNCPEAKGPRNMQVSTPVFLPENSQSHLHWDFKKNSCRKQIYSFNPSCGTEQTTYNKWYSWKDDFSSNQPECLWDEMEDVTYRNANAGTRETFWRELPAVPSWDSPCASDSNANQRGFKGLDFCQRAGNYLGQRSLPVSSSNWGDYKTPTDLMYSQVPQPKKRRLMYEKVPGRVDGQTRLKFL
The following text describes a protein:
Function:
Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Subcellular Localization:
Mitochondrion.
Sequence:
MNSFRRCSKTLLQTLLNANIAGSGPGRVFTRSQCYKAVNRRAITELKNLRRDPPKEPAGNSDRRTLAEALHGRIRATGPMTVATYMREVLLNPAAGYYSTKENVFGTTGDFITAPEIGQIFGELVAIWCINELQKFNYDGHIQLIELGPGKGTLMHDVLRVFERFGLSKDRVSVHLVEMSSNLQRLQADKLCNGMAHRTPADQSEPHVQEGTASSGINIRWYTDVVEVPKGFSIILANEFFDALPVHVFCKEASEGGASWKEMLVDINPELKEPSFRFIQSNRATPYSVVFGKRFDGKESLLRDRNRVEVSFETEQIAQDIARRIDGHGGFGLIIDYGHEGDKTDTLRSFKSHQLHDPLQDPGSADLTVDVDFGFLKHFLEQDDKAITLGPVSQGTFLEAMEGSARLKSLLSAAKDEKYRKMLSDGYDELTNPSKMGERFKLLSVFPSTLKEFLKTSNKVVGFDCKK
The following text describes a protein:
Function:
Probable helicase-like transcription factor involved in transcriptional gene silencing. Associates with SUVR2 and contributes to transcriptional gene silencing at RNA-directed DNA methylation (RdDM) target loci but also at RdDM-independent target loci. May be involved in nucleosome positioning to form ordered nucleosome arrays on chromatin. Associates with SUVR2 and functions redundantly with FRG1. Required for the efficient methylation of a broad range of RdDM target loci.
Subcellular Localization:
Nucleus.
Sequence:
MDSAIDISSDSDVEIQETRTRPQHPPRIAEGSHRRDLSTLRPHFLSGSSSGANGHTKTGLTNLDSRNGFESKPLPRAEHHTHIPGNGSIVTSRIPNISVGDYEKFSSQQAFKRTHPPTFSRPPFPPRPDIGTSNGNASHFRGGAHDDLGMGRVTNGTRILPPSVAHGTSASPSHFNGLSDPMHRNGIGEERNSENDERLIYQAALQELNQPKSEVDLPAGLLSVPLMKHQKIALAWMFQKETNSLHCMGGILADDQGLGKTVSTIALILKQMHEAKLKSKNSGNQEAEALDLDADDESENAFEKPESKASNGSGVNGDSGIKKAKGEEASTSTRKFNRKRPAAGTLIVCPASVVRQWARELDEKVTDEAKLSVLIYHGGNRTKDPIELAKYDVVMTTYAIVSNEVPKQPLVDDDENDEKNSEKYGLASGFSINKKRKNVVGTTKKSKKKKGNNNAGDSSDPDSGTLAKVGWFRVVLDEAQTIKNHRTQVARACCGLRAKRRWCLSGTPIQNTIDDLYSYFRFLKYDPYAVYKSFCHQIKGPISRNSLQGYKKLQAVLRAIMLRRTKGTLLDGQPIINLPPKTINLSQVDFSVEERSFYVKLESDSRSQFKAYAAAGTLNQNYANILLMLLRLRQACDHPQLVKRYNSDSVGKVSEEAVKKLPKEDLVSLLSRLESSPICCVCHDPPEDPVVTLCGHIFCYQCVSDYITGDEDTCPAPRCREQLAHDVVFSKSTLRSCVADDLGCSSSEDNSHDKSVFQNGEFSSSKIKAVLDILQSLSNQGTSNSTQNGQMASSSQQPNDDDDDDDDDVTIVEKTSLKSTPSNGGPIKTIIFSQWTGMLDLVELSLIENSIEFRRLDGTMSLIARDRAVKEFSNDPDVKVMIMSLKAGNLGLNMIAACHVILLDLWWNPTTEDQAIDRAHRIGQTRPVTVTRITIKNTVEDRILALQEEKRKMVASAFGEDHGGSSATRLTVDDLKYLFMV
The following text describes a protein:
Function:
FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MQDFIKIFIQEVVSTLEGLVGKAPSVGLEKEISSSDESFLKLISTPYARVVISAIEKEESSIELLAPVVLVTSLSDLMLGGEGASKEEMDNDDLDAFKEMASNIFGAIATSLKSQELLPKLNFTTINAEIAKELPKKEDYAKAMVFSFKMEAIKESQIILLTTAAFEGQFEKTHKEEKEETTEGVAEEVKTHDASLENIEIRNISMLLDVKLNVKVRIGQKKMILKDVVSMDIGSVVELDQLVNDPLEILVDDKVIAKGEVVIVDGNFGIQITDIGTKKERLEQLKH
The following text describes a protein:
Function:
May be a carbon dioxide/bicarbonate transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MQALPPKIPASVSGHGTQSRRHSLDWSHIGLPSRETQLRAGFVPSAAVVIVIFVGLFFGLTQYTELGTNAQEEVDRFYKYLVDVNIMVWIGFGFLMTFMRRYGYGAVALNYFASALMFLEAILMIGATQQVFWNYHRTKIQIDIALLIDCAFCAASGMIAFGAIIGKATPTQLLWLLFWQVPLYALNQQLVIHTFKALDMGGTIVIHLFGAYYGLAASLMISRKQPLHGLDNPKNSGAYLNDIFSMIGTIFLFIYWPSFNGALASVSAGHMEEATDAKKAAQFLSIVNTLLSLLGAGLSVFATSALVGGRFNMVHIQNSTLAGGVAMGAACTLRLTPGGALAVGLGAGAISTLGFQYLMPFLDRTIGLGDTCGVHNLHGIPAIVGTLVAGLAALGQHPDYLEHDTGRQQLGYQVLAGVVTMGIAIAGGLLGGFVVSWFNPRGDDPLTVPELFDDGPWWEHQRVEPMPISTSIHLSNMSAHGKSHHNQSVSVGQLNPIREGREIAVSGVPATGQRSVGEIAVTMQAAPVMASSAPVMGMHAAAATPIDTPLFADGHAMENAARPVQPMVAGAGNV
The following text describes a protein:
Function:
May be involved in cell division. May play a role in bacterial septation or regulation of cell wall degradation during cell division. Negatively controls the production of extracellular DNA (eDNA).
Miscellaneous:
MISCELLANEOUS: Processed by Prc protease in the C-terminus.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MKPFLRWCFVATALTLAGCSNTSWRKSEVLAVPLQPTLQQEVILARMEQILASRALTDDERAQLLYERGVLYDSLGLRALARNDFSQALAIRPDMPEVFNYLGIYLTQAGNFDAAYEAFDSVLELDPTYNYAHLNRGIALYYGGRDKLAQDDLLAFYQDDPNDPFRSLWLYLAEQKLDEKQAKEVLKQHFEKSDKEQWGWNIVEFYLGNISEQTLMERLKADATDNTSLAEHLSETNFYLGKYYLSLGDLDSATALFKLAVANNVHNFVEHRYALLELSLLGQDQDDLAESDQQ
The following text describes a protein:
Function:
May act as a specific coactivator for the mammalian TEFs.
Sequence:
MDILINEIINKMNNNISGLQCNLYGEDGSEASRVPVLDSECPPVSPTKRKHHENKDSDKGQMNKMRCLFASHLTNPNESTANQESWNVSSHGHSGLSGLHSHHVFAPFPIFAFDRPFEMNQQSLHPTSSMLPTPGTTTKQQQNRPSVITCAPASNRPCSLSSCHMSPDSCTSGSANKTNANNVCDPVIEEHFHRSLGDIYKEALPISNSVSTTGSVDDHFTKALGDAWLQIKAKGNSGTAPNHVGQS
The following text describes a protein:
Function:
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
Sequence:
MAKIYTDREASLEPLKGKTIAVIGYGIQGRAQALNLRDSGLEVIIGLRRGGKSWELATSEGFRVYEIGEAVRKADVILVLIPDMEQPKVWQEQIAPNLKEGVVVDFAHGFNVHFGLIKPPKNIDVIMVAPKAPGKAVREEYLAGRGVPALVAVYQDYSGSALKYALALAKGIGATRAGVIETTFAEETETDLIGEQIVLVGGLMELIKKGFEVLVEMGYQPEVAYFEVLNEAKLIMDLIWQRGIYGMLNGVSDTAKYGGLTVGPRVIDENVKRKMKEAAMRVKSGEFAKEWVEEYNRGAPTLRKLMEEARTHPIEKVGEEMRKLLFGP
The following text describes a protein:
Function:
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTSKINKIVNGPIPDSFLFDESKRLDSLKFDGTNLEVLDQLLLPHEFKYIPVEGVSDAFAVIKSMQVRGAPLIAVVGSLGLLLEIQKASELDSESIIQKINFLISSRPTAVDLRNSLNGLKPILESQDYSDVVKLEKCRSYLLNVYTDEKLQNRILVWNAYQELLSAFPDKEKLTVMTICNTGSLATISWGTALGVIRALHSENRLKLVYVLETRPYNQGIRLTSIELLHGEVPFKLITDSMAAWAMKNHQVDCVLTGADNVARNGDTANKIGTYMLAVLCKHHNINFYPVVPFTTINKNIATGEEIKIEERPSAEMLRVNGVLIGNSECPVWNPAFDVTPAHLITKILTDFGNWPPEMLEQQIPK
The following text describes a protein:
Function:
Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MASQPSPTSSTSSVGSRRSIDQNGPPTLEDLVKHFVASKRSLNTQTVLWRANDIVNTARQLLEENAVLAAKNTSIRNLVEQQVDALEAVRRGIDVFDAEITVEFKPRCNLRGTPQKHLYDFIDSATVSNLEGTLRACIDRYNAAHRILDESNDAFDTSLDNLHTSIENVPLTPASASLPSPIPSLYQDLEAHAKEAAQAFQSLVQHYDLCVTALRHTEGGSAAATEATGDAPTHSTDEFAAPPEPMSEAERQEMVAVLVNDAHEVNDVVTEIRERGSEMTFLLTQIENHINHLRNEASGLSSILKMISQITGEVKTHITTSRSFHALWLQDTRPTLVTGIEEWENQRDFYERFDLAYAELLVEISSRPKKTREGEKKGRRCTEGA
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MDCEDTDQMNNNSMELENTQQRKLFYRDLLNSVETIHEKEELGLDTVREIGDLLKQVNIIEAEHNINDRYQYPEEILLDSMVLSSASGILKKCVEAVDVNVSTYVSSEFTEKIASFCNSEGDFDAQDLVKLLPDAQDIIPKVPEYFFVYGTYDMQNLPKPKEKKQRQKKEKENFQKKEPEKVTSVEKEEQGIEEIVKILYDVLTECYERNHEQPVKYYDYVVDTSSFSNTVENMFYCSFLIRDGRAHIDLDGKGEPYIKPMKKRQLKQFRDDGGTNSQIISTITIPEWEMFKREGYIQKYKARK
The following text describes a protein:
Function:
Required for proper spore morphogenesis. Important for spore germination.
Subcellular Localization:
Cell membrane. Spore membrane; Multi-pass membrane protein. Spore outer membrane; Multi-pass membrane protein. Note=Inner and outer prespore membrane. Mother cell membrane.
Sequence:
MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFYATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS
The following text describes a protein:
Function:
Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity).
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.
Sequence:
MSEIRVSCASSGVSVSAARDQFSSLPHLKAWIELEFSVSVSEQLLLTVAAEQVKMAHLGTQNELFVFDRSVVGGTVSNEHKYSAPKLKTLTPGTDPSQWALTVLTHCSRLVEETKRVTAEIATIKRATNVAITQMKQHSQNLDKNLLNVKEYSKELNQGITPLLSVDLAQLRDNTRAVKLVAPAVFGKKQFLNDWLDLQQLQSIVVEFKADFPSCMDKLQTLEQDLAQLSKDTQTLVNSTDVWIGGTNSDVLCNEAVGILRKLSELTSGDHVTNEAVKSVQNCQSQILDLHKALSKAKFQTVQHSQKVLQSISQLQSRSTKLKPKLTHIGSELTKYEEKRVQAMKQVDVEFVYGCVLVEMLRRTVWSQSGGENGSVKSEIGTRVAWKKQFQDTFPFVDILNEQEDLTIDTISTSSPSIVHNLVIARPVVTDYISQVSSKEVRNNLESLLGGVTGSAAATSSFPRSLFRNGSISGSLMAERAPISSATNADDKIRGYEARIRKLEDLLYKQRMSQDTSRWSVSPGTPSAGFAVVSPGQLSSEARGSSLSPEPTETREQVKAREKAEEEARKAEEERLARDKAAAEALQSKVDQLSQSLLHTENEKNDLMANLASMESDFSRERRCLVQEISELKLRVEELEEQVETAAETSIERHQRADQETEELEQRLKAMTLAQNTVDDENSRLKITLQDMSQRLYTGYKRNCVLLESLGLQAQKEYDADGSEVVSFDIHRVKGLRKKHRGKKGEKTEKDSESDSTDDFSALYWATKTTPDSFESSYRTFLARIFLDYDLYVEKVAKRFEDLEHLARKLQKEARNYRTMTQQLDDETRSKIALNRFKVGDLVLFLPTRDPSRQPQPWAAFNVGAPHFFLKQKPGRELKDRDWLVGRITGMEERVVNGGIGDREENPFDLGQGLRWWWLEAEEE
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MAPEDTNPQSSHRRTRSTSRSRPTTPLRPSSRSSFRSSARGSVYGDNAAFPLNAFEPAFAELADAVADLEANMMHFQLMHESLARFSESFASFLYGLNMNAFCVDFPEGPITESFKRMKLKEEEMQASSQIPSAWRGDPPISTPTAIYPRTDIRILIVKSGGYTWWKRRASWGSG
The following text describes a protein:
Function:
Permits nitrate and nitrate transport into E.coli; Involved in excretion of nitrite produced by the dissimilatory reduction of nitrate.
Miscellaneous:
MISCELLANEOUS: One of the activities induced in M.tuberculosis by hypoxia is the dissimilatory reduction of nitrate to nitrite, which serves to provide energy as the bacteria adapt to anaerobiosis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRGQAANLVLATWISVVNFWAWNLIGPLSTSYARDMSLSSAEASLLVATPILVGALGRIVTGPLTDRFGGRAMLIAVTLASILPVLAVGVAATMGSYALLVFFGLFLGVAGTIFAVGIPFANNWYQPARRGFSTGVFGMGMVGTALSAFFTPRFVRWFGLFTTHAIVAAALASTAVVAMVVLRDAPYFRPNADPVLPRLKAAARLPVTWEMSFLYAIVFGGFVAFSNYLPTYITTIYGFSTVDAGARTAGFALAAVLARPVGGWLSDRIAPRHVVLASLAGTALLAFAAALQPPPEVWSAATFITLAVCLGVGTGGVFAWVARRAPAASVGSVTGIVAAAGGLGGYFPPLVMGATYDPVDNDYTVGLLLLVATALVACTYTALHAREPVSEEASR
The following text describes a protein:
Function:
Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).
Subcellular Localization:
Nucleus.
Sequence:
MDLDQTDLEVSPKLESTSLPTSGSAAISSSSINPAVSFKRKKTFHEQETERKAEALSEILLLMDEFAPIIPDSVTDHHLARSGFQCDDVRVKRLLALATQKFISDIATDAMHYSKLRQQAVQGKERRQTLKDKRTVLTMDDLAAAMSEQGVNIKKPDYYV
The following text describes a protein:
Function:
Matrix metalloproteinases (MMPs) or matrixins may play a role in the degradation and remodeling of the extracellular matrix (ECM) during development or in response to stresses (By similarity). Required for plant growth, morphogenesis, and development with particular relevance for flowering and senescence. Active on McaPLGLDpaAR-NH(2) (QF24) and myelin basic protein (MBP) and, to some extent, on beta-casein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Domain:
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence:
MRFCVFGFLSLFLIVSPASAWFFPNSTAVPPSLRNTTRVFWDAFSNFTGCHHGQNVDGLYRIKKYFQRFGYIPETFSGNFTDDFDDILKAAVELYQTNFNLNVTGELDALTIQHIVIPRCGNPDVVNGTSLMHGGRRKTFEVNFSRTHLHAVKRYTLFPGEPRWPRNRRDLTYAFDPKNPLTEEVKSVFSRAFGRWSDVTALNFTLSESFSTSDITIGFYTGDHGDGEPFDGVLGTLAHAFSPPSGKFHLDADENWVVSGDLDSFLSVTAAVDLESVAVHEIGHLLGLGHSSVEESIMYPTITTGKRKVDLTNDDVEGIQYLYGANPNFNGTTSPPSTTKHQRDTGGFSAAWRIDGSSRSTIVSLLLSTVGLVLWFLP
The following text describes a protein:
Function:
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Subcellular Localization:
Secreted.
Sequence:
MCLRMKPIQKLLAGLILLTWCVEGCSSQHWSYGLRPGGKRDAENLIDSFQEIVKEVGQLAETQRFECTMHQPRSPLRDLKGALESLIEEETGQKKM
The following text describes a protein:
Function:
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin acts on X.laevis Nav1.6/SCN8A and insect BgNav1 channels, and also displays a small but significant effect on X.laevis Nav1.4/SCN4A channels. In mice induces nociception (licking and lifting behaviors) during the first 15 minutes after injection, and increases the release of TNF-alpha in J774.1 cells.
Subcellular Localization:
Secreted.
Domain:
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
Sequence:
KGGYPVDSKGCKISCVINNEYCSRDCTSGYCYFLRWGLACWCDGVPPQR
The following text describes a protein:
Function:
May function as somatic storage protein during early seedling development.
Sequence:
MASPTSILSFLLLLPLTAAVSSTQVIKMYPKQHVVGAEPKCESWKFSIEVNNAGSWKSIPPTCIDFVKDYFNSGRYLADSRSVAAFSLNFARSVKVSEGDAWIFDVDETLLSNLPFYKDHEFGLQPYNDTSFFEWVKKGSAPALPASLTVYNWLKKLGFKIFILTGRDESLRAVTEQNLIDAGYSGWEKLILRGPNDDKKNIEYKSEKRAELVNQGYTIQGSSGDQWSDLMGFALAKRSFKLPNPIYYFP
The following text describes a protein:
Function:
Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters.
Subcellular Localization:
Cytoplasm. Mitochondrion outer membrane; Single-pass membrane protein. Nucleus.
Sequence:
MGYARKVGWVTAGLVIGAGACYCIYRLTRGRKQNKEKMAEGGSGDVDDVGDCPGPRYNDWSDDDDDNSENKGIVWYPPWARIGTEAGTRARARARARATRARRAVQKRASPNSDDTILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSAGNEETKFQVLKLLLNLAENPAMSRELLRAQVPSSLGSLFNKKENKEVILKLLVIFENINDNFKWQENEPTQNQFSEGSLFSFLKEFQACADKILGIESHHDFLVKVKVGKFMAKLAEHMFPKSQE
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSLMYLSRQNTARFPLRRKEPNCSSEMSDRRATDSTRSFHRSPPRYADRSTRALNGTFRDERSQSRDSISSEYGTPGSSPTPRSPSSPSIPDIPSSPPPYSDVVSGRVERRTEVKSNQFKNANSMPSPRQSMPSSDSNDGFTTVTRRKVVDKSSKKPFFDTPPRRAVVKISGTMADRVERRVENMDNSWSFLENSAVKKKVRACYSTILPIQKPAIATIQMGADLFLAAPKGYGRSNAWMIPVLDAVINSRPSSGVINCIIVAQTEHKAIEIGAHLNILLPRDQHEKRLISGQWFWKAEKMHEYFQRIRERGAPLLITTAKLLPTFLTDAQASLDLRTIGFALHLKPTYLQADLDQLKFIIFDEYDEILLSESERWMLERRETLTTRTQVILISTEEDTGKNVDLILRKRWFVEVRANRVDEHLPPQHFSCLADTDDAALALLHIIEKGPSPIAVFFNTEETALRMYDWLMDRKIPRVERLCGKGNHELWSQQLIAFRTGKVDVFLVTYDYAKYVDLDTLALDVFFELPEYLDRHGIRVTRNGRMRSGRTITFICPGDLDMLPGLMTSHANRGLPIDSLKGVWENLQDQKNRLSARHSRAVFRVQLHRQLEALDITDEEDEQAVKKARESMRRNNEQVRASICEGRARSMNRK
The following text describes a protein:
Function:
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes anterior neural development.
Subcellular Localization:
Secreted.
Sequence:
MPVTAMCLQDSKKLKKAKLTRKKVTPFPFSRMVLCLSLVFTLYVEATNARCLRPRSKELLCGSELVDILQFICGPTGFYVSKGASFRNRNRPGIVEECCFCGCSVAILESYCAAPVTNFTGREEQKS
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MEKESRVHPACINASNPYHECSQYCFRKIAEARATVTEELPNAGPVEDEKEQAPEVEEEKEAPVPVPPLIEDESGLDERQKKLRLLQRKMDEARKKNEQAMMAERKKQDAPKEERGVSKQKWFEEKQKQAGKRLEFSGIDKSKMYMLDTQEAAEEKYKKRDKNPAPFGWDVFNQKSLYNAYKKRAKTIPNTVEEYTKVRDNDPDFYCNETSLQYGKTPAVPEEFVDRMVQELEGRISKRKDFSRRRKYHEEKDIDSINERNEHFNRKIERAFGKYTVEIKNNLERGTALPD