lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.
Miscellaneous:
MISCELLANEOUS: Present with 279 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Sequence:
MALFRALYIIWVFLLIPLSNAEEFTPKVTRTLSRYVFDIVNFDDSNTLIRAEEDSVEISFDAGENWKTIDEIEEPIESFVVDPFRGHDRAFAFVKTAPKFYVTDDQGKSWRPLTIPISEKASNYFCDVTTHPIKKKHLIIRCDLLTIKNSGLMYVGREIYTTNDGVSFSQVKPSFGKIDGHISTARCDFIKSSEDSDLGGNDASILCLFRNTEYIESTGSTIDKSELILSADGGETFKELVQFKDKVVSRYEILKHHVIVLTQDDMYNEMSSTNIWISNDVSTFQVARTPTKIRHVNMGQIHEDSIGRIVLPVSRERDDEDSNQPGAAEVLISDSEGLKFLPINWIPNNQFGYINVAYPGFLKGTFFGSFHPFIEYSDRKRKYSRQKVREETKVSVDNGLTWTNLKVVDRENVDLFGCDVTKPERCSLQTHFYDLRNLNPSAGIMMISGIVGDGSAYNWKEEKTFISRDSGLTWRLVHNSTGLYTTGDLGNIIMYIPYRSNENGDVPSKFYYSLDQGKTWGEYDLIMPIYPYRLVSTISDGSGSKFILTGTSITEDPIFITYSIDFSAVFDYKSCEEGDFEDWNLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLSLDETPCNSCTGSDYECSFEFVRDAKGDCIPDYNLIALSDICDKSKGKSVLVKPLQLIKGDKCKTPMKIESVDIPCDEIPKEGSSDKEIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGGQTIKRFDTDGEKIVEIVFNPYFNSSAYLFGSKGNIFLTHDRGYSFMIAKLPEARQLGMPLDFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFKYPSNDDMVMCQVKEKFSQTRSLVSSTDFFQDDRKTVFENIIGYLSTGGYIIVAVPHEDNELRAYVTNDGAEFTEAKFPYDEDIGKQDAFTILGSEEGSIFLHLATNLESGHDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNSEKVGENKEDEQLKTKITFNDGSDWNFLKPPKKDSEGKKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGDRLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYSTDFGKTWKDYKFCGDKVLVKDIITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQCEFDITGRKRADFKYSPLGSRTGCLFGHKTEFLRKTDEKCFIGNIPLSEFSRNVKNCPCTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKGGLKLDAHLAPHPCPGKEKAFREKYSINTGAYALVFVTILLVIFFVAWFVYDRGIRRNGGFSRFEEIRLGDDGLIENNRTDRVVNIIVRLGLCISLITKSAFQRAKAGTAQLSSKFRARFGNKKGATYSSLLHDQLSDEPDGFHEDSNDLSSFRGQGSNSEIEQEDVDTSQQEHTSRTDLLGASNIPDALPARSASHESDLAAARSEDK
The following text describes a protein:
Function:
Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
Subcellular Localization:
Nucleus.
Sequence:
MQNGTTIGIPPENERVTERAEPVPSDLLPNNSPVNSPTIDPTLSEIKDVAADHNEEPPSKRRKVAGSTPSRRSHSRAASPPWKKAGADGPTSKIVDGKRRSTRVSNVGPVEQPPSDAKPTRSSQKQYVSKAVSSQRNAAVSSPLPMSPSRSGINRRSLAGVAVNGSPSTTAKGSIGRRRRESPSPVSKRASTRTRPDNMDAYHPSNGVTPRSNSTKTRSTRSFQLASSDFREETADDIGNDGQDEHGQRIQRLRIKVKKPALSIQHPSHVLPTRKYGSFKEWLENEGTGPGRMLTMTDALEEAQKRRQVTEAMEPGGLLSSEVCSAFLPEPQEELPQQFSHQDHLVAHALYFKKLLDKEHRAHRQAAKSLAAACAEVWRKRNKDPEDILREQQEEMRGKRKQLAKDLKKMFELARAEIDRVRLARWEEEQKAKDQRALDRAIKQSTMLFEKRRLEILGETGSDAPETTTDDEEVETDNGSENDDEEGESNMSTETEEEDGDDRDDDVGLTAEELRLKYANLPDTNPHPDQSPYSDEDSEDSDDIAADNTPGDTSGGVNRSPPPDSSGQVELDEVDPVLIDDSDESTDMDDDMGDSDDDGYSEAESDDEDGGEPGLLGFFSAKDLSLSNLHQTNSGEGDTHQTGADGDRNEDSSFDESEFGSEDPDEVTLVPTGPTNKDLSTPATVTASAELEPAAMTPSIDQTSTEEPIAIGTETPIETVAEDAAALADTEPVDVDVLDTSTNDSVPPVMSPATNLLKQIERQQHEPYHSRAASSEASPGTVATKPSEPESVSSIEAPAEKHAQPSESPGPGLKTPIPHLLRGTLREYQHFGLDWLAGLYSNHINGILADEMGLGKTIQTIALLAHLAVEHGVWGPHLVVVPTSVILNWEMEFKKWCPGFKIMTYYGNQEERRQKRRGWMDDNSWNVLITSYQLVLQDQQVLKRRSWHYMILDEAHNIKNFRSQRWQALLTFRTRARLLLTGTPLQNNLTELWSLLFFLMPTDGDEAGIEGFADLRNFSEWFRRPVEQILEHGRETMDDEAKQVVTKLHTVLRPYILRRLKADVEKQMPGKYEHVVYCRLSKRQRYLYDGFMSRAQTKETLASGNYLSIINCLMQLRKVCNHPDLFETRPISTSFAMPRSVATEFETSEALVRRRLLYQHPLEKLDLDFLNLVPISREDISRRLADDSARIMAYAPFNTLRERQYHRTNWEMKFNGSTVQSTLEALENDCRKRRMAELERSLYFESKRHGRRPVYGSSLIEFLTADSKQRPTAHGPLRKRSYADWLSSQSSVLASMMMSLEERSQAMDGYIQRFACVTPAAVAAGVTEAALTPISTRHLTNKERFPPHDPFHEAQMRLSIAFPDKRLLQYDCGKLQRLDKLLRDLKAGGHRALIFTQMTKMLDVLEQFLNIHGHRYLRLDGTTKVEQRQILTDRFNNDNRILAFILSSRSGGLGINLTGADTVIFYDLDWNPAMDKQCQDRCHRIGQTRDVHIYRFVSEYTIESNILRKANQKRMLDDVVIQEGEFTTDYFTKLDVRDMIGNDEALKDEASAAMDRVLENRVTNTSRVFEQAEDKEDIDAAKNAQKELEHADDGDFDDRANANASGVTAASASASGAGQTPTQAGTPLPDEAQQSLNANNAEVAEDTADSDPSVGHIDDYLLRFMEWNMKDEPLVLPVDKSMKKSKKGKEHRLRKRRR
The following text describes a protein:
Function:
Does not possess a ribonucleotide reductase activity. Betaherpesviruses probably use another strategy to expand the dNTP pool in a quiescent host cell.
Subcellular Localization:
Virion. Host cytoplasm.
Sequence:
MNPADADEEQRVSSVPAHRCRPGRIPSRSAETETEESSAEVAADTIGGDDSELEEGPLPGGDKEASAGNTNVSSGVACVAGFTSGGGVVSWRPESPSPDGTPSVLSLTRDSGPAVPSRGGRVSSGLSTFNPAGATRMELDSVEEEDDFGASLCKVSPPIQAMRMLMGKKCHCHGYWGKFRFCGVQEPARELPSDRNALWREMDTVSRHSAGLGSFRLFQLIMRHGPCLIRHSPRCDLLLGRFYFKANWARESRTPLCYASELCDESVRRFVLRHMEDLPKLAEETARFVELAGCWGLYAAILCLDKVCRQLHGQDESPGGVFLRIAVALTAAIENSRHSRIYRFHLDARFEGEVLESVLKRCRDGQLSLSTFTMSTVGFDRVPQYDFLISADPFSRDASWAAMCKWMSTLSCGVSVSVNVTRLNADVNSVIRCLGGYCDLIREKEVHRPVVRVFVDMWDVAAIRVINFILKESTSELTGVCYAFNVPSVLMKRYRAREQRYSLFGRPVSRRLSDLGQESAFEKEYSRCEQSCPKVVVNTDDFLKKMLLCALKGRASVVFVHHVVKYSIMADSVCLPPCLSPDMASCHFGECDMPVQRLTVNVARCVFARSDEQKLHLPDVVLGNTRRYFDLSVLRELVTEAVVWGNARLDALMSASEWWVESALEKLRPLHIGVAGLHTALMRLGFTYFASWDLIERIFEHMYFAAVRASVDLCKSGLPRCEWFERTIYQEGKFIFELYRLPRLSIASARWEALRADMLEFGLRNCQFLAVGPDDEVAHLWGVTPSVWASRGTVFEEETVWSLCPPNRECYFPTVVRRPLRVPVVNYAWLEQHQEEGKATQCLFQAAPAIQNDVEMAAVNLSVFVDQCVALVFYYDSGMTPDVLLARMLKWYHWRFKVGVYKYCAS
The following text describes a protein:
Function:
May function as a potassium transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVGFIGSVLIKLIEFEVPFIDCLYIGYSALTTTGLVTVDISGWSSGTLFLLVILVQLGSTVLLTLPIVLLRRFFIRSVYSNSSIISAANASPDLISTIIHSHLPHHDFKDDDDENDNNNNEENDDNDDESYQHNNNNNEEHDDNDIEIGGILKLDSPIDHNLPNGFQDDNAPHHYNIPIVGKIDKKSRKFSLDSPSSPIIQQQQQQQQQQQQQQQQQQQQQQQQQQQPSTTTTTTTTTNSTLNKSTNNSTNNNNNTNDSQSIQKEVNIDINRIDSLQELQEQQEHQQQQRQLSKPLNLNSYEDNMEYRSLGKLLVIIPCYIITIYILGFISIGAYIAGSESARSIMKANGVNGWWWSLFHTFSAFNNAGLALFSDSLIQINEKYFLLITLSILIFLGNTLFPVFLRIILLVVSKFTKDPEPYRNLLENPRSIFTHLFPYKETVQLFVIWCIFNVSQIALMALLDVNDKAFTNMNYGTILLNYYFSSISTRTCGFNSVDLNLLSESVLLLFVGLMFVSSYPFIISLRRSAVNNKYSNQSREVMKEVLIRDIFVPYICILFIAIFESQLLESGVITVFQILFEAISAFGNVGLSISITLSTYSKLVFIALMLAGKHRQLPESVDESVNPALLKKNAVISKIITRYKRRKL
The following text describes a protein:
Function:
Involved in proper sorting of the v-SNARE protein SNC1.
Miscellaneous:
MISCELLANEOUS: Present with 450 molecules/cell in log phase SD medium.
Subcellular Localization:
Prevacuolar compartment. Endosome. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Perivacuolar punctate structures and endosome.
Domain:
The PX domain binds to phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the punctate structures.
Sequence:
MDYNIFEAVHEQQSSTSDMDLSEEDNNPFVGTHHLYASGIGTTIGEARPENENSPPSSSSLPSSPAHSSSAGSSRASTSSSTSSHAVVEADAETEPFVSLSMSTTATISKFTPHDMNGTQQIQIIDAGDFKDPWGKHAIGYVILYENNKIIRRYSEFHSLRQSLTRLLPTIIIPPIPSKHSLLKYIWSPINAANDSKIISTRKKMLNSFLSNCLNIQEISNDIVFQKFLNPEFNWKDVLSSSPIIILPLNNLLAPPLSPTKPSPLHSILPIPSNSSLRNYNSIWQQHITVKSHNEISNLPTEILQNESQFTHIENLFQNYKRIITHLLKNIRSNKSHFHSLSTYFAELGAYYNAFSLENDITMPNSLRESENNSNNPMMEIISHIEKTGHSFDVIYISSEILIEKYTSILEDPINELLQFLNESFKVLNFKKLKFLQFKILERLIIEKETKLSSLTEIENQLQKINESLTRSTILTDENYKDTKAADLTFVKKDVRSLSKSSSNSSSSGHQNEIHIGASKLNYKTSTPTMNLNKLEIKQLTEQERSKQIKQLNQDLSKLKDCLSICISDMLEINNSSYNSLMHTYNHINLTIGKILKLFAASFKAWIKECLKNWKLAKLQIDEAL
The following text describes a protein:
Function:
Promotes the exchange of Ras-bound GDP by GTP.
Sequence:
MWQKPSLTKSMMNEVSSNSPKSPTLTSSPSTQSFANRVLPGRNLDGGGGGSNRLIFGGSGGGSGGGSLPSSPVSSPVNPFNLNGGGGGKSSRRRGVTVAAGSEQVETRRKILLGNSRPFRRRARSMEILNSWDFIPYQKKPSDDEQGQVDQYIQGENDEDLTSYESYITNNNTTTTTNTNNSNNNNSNNDGSGSGSGAGGSFIGTTTSAKTTSTTSTSAATTTTTTTTSSSSSSPSSSSPSSTSPTIASNNDNNNKIEPPQPSKIANSVPPLTLSQSQTQQQQQQKVKPPPPSPRFSTNSSGSQSPPVPPRSSKSLGLSNDFSISLSSSMSSNSLLISGSINTLPTSSSSSSSVGGSGASAASASISSSSSLSSSSLSVSKLIYENNEENKFVVVSGPKDQLVEYLCNKNKLDFSFVNSFILSFRYFIEPEELFNHLMVKYETKVQTTSSIKVSKQFEEIQDRIRQNILIIISVWVDCNYSDFEDNLSLHKRLFKLVQDTPHAVFLRDSIDRQKVSKIPILDLYEKLKDELLLSLSPRGSLSGSGGISNNNNGSDLKNSNNGNNSSNNNNSSSNSSSSSSSSDIKNIKNSFFSLTTMMDWLMNHLSIGYATADSILKKLFKLKVIGSLGSGGGFTNISSSHTNSNSKSSKEELYFFTSTKSIINKEIYSRSFMDYSPQDIAKQLTLIEFKLFQSVKMKELYHKSWTISKSKFENSPNIMSLITMSNKIANWVATEVVTTPHPKKRVEVLKRFISVAEHCKKINNFNTLMEVISGLSNSAVSRLKETWKSLPTRYVNSFNSLQNFLKTDENWKSYRQTLKTKETPCLPYLGLFLQDINFIEDGNSNLSSENDWVNFKKMNLLTSVFTEIQYFQRHPYFSFSTHQNIQTYFEKDIVILPEKELYAFSKFIESPSNPLFRLSKSKNQSIFNI
The following text describes a protein:
Function:
May act as a bridging protein that binds pectin and other cell wall polysaccharides. Probably involved in maintaining esterification of pectins (By similarity). May be involved in the specific O-acetylation of cell wall polymers (By similarity).
Miscellaneous:
MISCELLANEOUS: Contains 2 motifs that are conserved in esterases, but it is unlikely that this protein belongs to the catalytically active pectin esterases.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MSKNSNVEENGGAKPICEALRRFKRSRLVFEPSLGVLGFFLVGVCLVCSFFFFDYRSVAKSYGLSDKSERFVWLKFDNISSSSSSSSNSSKRVGFLEESGSGCDVFDGDWVWDESYPLYQSKDCRFLDEGFRCSDFGRSDLFYTQWRWQPRHCNLPRFDAKLMLEKLRDKRLVFVGDSIGRNQWESLLCLLSSAVKNESLIYEINGSPITKHKGFLVFKFEEYNCTVEYYRSPFLVPQSRPPIGSPGKVKTSLKLDTMDWTSSKWRDADVLVLNTGHWWNEGKTTRTGCYFQEGEEVKLKMNVDDAYKRALNTVVKWIHTELDSNKTQVFFRTFAPVHFRGGDWKTGGTCHMETLPEIGTSLASSETWEQLKILRDVLSHNSNRSETVKVKLLNITAMAAQRKDGHPSLYYLGPHGPAPLHRQDCSHWCLPGVPDTWNELFYALFMKQEAPSSSKRVEEANSTGNVTMS
The following text describes a protein:
Function:
Acts as an effector of RABF2A and RABF2B. Involved in vacuolar transport of storage proteins. Regulates membrane trafficking to protein storage vacuoles (PSVs). Binds specifically to phosphatidylinositol 3-monophosphate (PtdIns3P).
Subcellular Localization:
Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein. Note=The endosomal localization depends on the active state of RABF2B. Binding of phosphatidylinositol 3-monophosphate via the PX domain is required for the endosomal localization.
Sequence:
MNLYAHDLSLLDFNYNVSGPFGEPLSHRFLSPGPFFQGEEDDYRRNTSYSHDGANGREPDTDSRASPPHRHDGRSPLPLGMDWSSPPRHLEGRDTVWPHDHRTGWSYCVTVPSWVDLPKSSVSDPAVFYRVQVAIQSPEGITSARLVLRRFNDFLELYSSIKKEFVKKSLPQAPPKKILRMRNQTLLEERRCSLEDWMNRLLSDIDISRSALIATFLELEAAVRSYFNDEYQETEDTSGDIPSLLPTTISDVPGSSSVTIDHDNDSADETSNASTMKHDEANLKNLFSRNSTAVDNVTDWHELITEYGLLDQSSFQEKVERLSSTNGDAATGTVTRGGISSGVGIQRLDGSDRKFQELTIESIKKTHVSDFEASTAVEPDLVNQGAMDIHGEAHGNMYGAVGGDTETQKDLAIVFQSEERHKLKRVIDTLKQRLETAKADTEDLISRLNQELAVRQFLSTKVRDLEVELETTRESCKQGMEKTVLDEKERFTQIQWDMEELRKQCMEMESFLNSIKDEKTHIETANESLVQENQMLLQQINDIRENFENFHKEHEELEVKAKAELKVLVKEVKSLRTTQSDLRQELSGIMKEKLEMERIVQREKDREETAKNADKKLLHECDVLQNRLQECNVKFDIEEEGKLIMDSSSLSEAIELLATSDNRIGLLIAETQLLSEEVEKLKLTSGGHRGTDDLVRKMLTEVLIDNARLRKQVNSVLRCSLSGHGISVREAGTEVDDEEGSIDLARTVMSKILEK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTDWKTTITPEERNGNSIKILDFLMQWYPNFNRAEALVRANTLEDRIFNTPGIISKNDYIERIAKKIYAIGESLEAKKAQAGMTNNPQTPNPMPTTPITPLIQQPITPVQQQVPPQKQPQPVYNQQQNQQQNQNQYTTTYPSPNTPQQSNTPPISNNNSNNNSNNNLNNNNNNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTVYAQPLTPQQQIQQQQHQQHQLYLQQQQQLQRLAQQNQQQQPTIMQQVQNQQPTQQQQQQQQQQQQQQQQQQLNQQQINQIKQQQQQQQQQQQQHQQPVQMPSGVTTNKQSPQPQNTPLTPQQQQQLLAAQQSHAQAQANQNQQLQNPKRISSTNNTHLMPCLPSTLYPTATQQDINNMYWERVSSIKKYIPEIEAIIPKIIENFSQSQNQQPQKVETYKKKFLDFVQMVKVTPETVVPPLNLDELTNAERYLMNMYLSSLSEEEQFKKILGTIDDRSNDNLIHFEKDLLNAFERTKRYFSDTFLNKTGGVTSKAPSILWFKNPALNNPFTSATKCQFSDPIVPKKKQHILLDSWTPEFKKIKKGNYEIFEKDQKIYNNLKKDLIDFTKNDNTLLPAKFIDKDTIIISETINGGDGGNNLYIHFNQCQFSTSWKGSKKNPAMFVCSSPNIQISSDGELFSIQPLCGLSWDRAEIIIKHYKQSLNRGDLISKELSQVISLNRYTIESHLDLENAKFFIQFSTKSTLLLKSKKQQQQQQDEKINNNNNNFYNLSILLEVPNNYPYSPISYSFPPEYQLTPYLKDLESKMNKEFENSNDLNQLNNNINNNNNNNNSFSDNTQLPTNQSIVESLKIFEKVLKDLV
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDIFRLFIISLMPVLKVLLVLIAGLILATQRFDLLGCDARRHLNKMVFYVFYPALIGCSLADTMTLEGLADLWFLPVNVLITCVIGSILGWILVIVTKPPRHLWGLVISCTSAANLGNMLLIILPALCKEKNNPFGEVASTCSANGKAYASLSLAIQIIYIWSVLYFLLRMYANNEVKESNSNNSIIVAANGCTRDVLHDPVGLPQIQNDGNQKVSTTVKFKQLFMKIMRSESLRKIFAPATIAAIVGFLIGIATPIRKTFIGDSAPLHVIYSAAELIGNAGIPSVTLIVGANLLKGLSGSGVRPSVIIGILIIRNIFLPVSGIGVIKAAKHLSLVDENSFYLFTLLIQYAIPPAMNIGTISQMLGSGESEFSMIMLWNYILAIFTLTFWIGFYMWLVI
The following text describes a protein:
Function:
Promotes invasion of host epithelial cells by adhering to receptors on the host cell surface to facilitate endocytosis of the pathogen into host cells. Probably binds integrin ITGA3:ITGB1 via ITGB1, on the cell surface of host alveolar epithelial cells.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKSLSFISLACLTAVHAASVTFKVIAPTAESSVQVNINGQLTQLKAQDEDIPYYTGSAELNDGQSYKYVVDGAAETFERILNGTSTKNEFFNRPITYATNIPELPNILSEGSWTRGETTDPLWDSNYVPSIFVTGKSDEMEDLITNVTKKTYQAKITFIGPENITTIENCTFGLHKPGRKHNDAKQTWVWTLPEGQYVAKRSWFKIRHMEEDPTQLREKLYADIARKMGTYANEANMVRFFINKEGMGTFNMLDDVIMYSYINAMFYNGNPPQQLGALYDGASGAAFNASGDMDSFIPNVESPLDQDALMPFSKAFAAVDFSNDDQVKAISQYFDYDQFLRFMVMEFLTADWDGYWQEQTNDGAYIDVSDNNKVYYLAQDFDATFGVNLDQERDFVNTPYTDFPTKFPGGILINKLLENPTTKATFETYLKTTVQEIFNNATLGAYVTARHNFLAPDLKWDRSIKQRSPGNIFGWTYEQTYQNLFEGVTAPGKEQGGAEWGLLEWVAAKEKAVRSSLKLSETATTSTSATIAAPATSESASQDNTSDDTDSASTSSSTLNQAAADTSSASKSAPTFYCLQLVLYLSLSFKNLYKYI
The following text describes a protein:
Function:
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
Miscellaneous:
MISCELLANEOUS: Two isoforms exist, a major form and a minor form. This is the major form.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
ARRRHSMKKKRKSVRRRKTRKNQRKRKNSLGRSFKQHGFLKQPPRFRP
The following text describes a protein:
Function:
Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (By similarity). The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin. Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways (By similarity). Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (By similarity). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (By similarity).
Subcellular Localization:
Cell membrane; Single-pass membrane protein; Extracellular side.
Sequence:
MLVFIFLAVRLSSENESSSQTNDCAYFMRQCLTDTDGCKQSWRSMEDACLVSGDSCKINNPLPCNLSIQSLVEKHFQFKGCLCTDDLHCTVNKIFGKKCTNKTDSMKKDNKYKRNLTTPLYHDTGFKQMQSCLEVTEACVGDVVCNAQLALYLKACTANGNLCDVKHCQAAIRFFYQNMPFNTAQMLAFCDCAQSDIPCQQSKETLHSKPCALNVVPPPTCLSVIHTCRNDELCRTYYRTFQTECWPHVAGKCREDETCISMLGKQDLTCSGSDSCRAAYLGTFGTVLQVPCACRSITQGEEPLCMAFQHMLHSKSCFNYPTPNVKDISSYERKHSKEITLTGFNSPFSGELIYVVVCMVVTSGILSLVMLKLRIPSKKRDPAPIEIAGAVIIQ
The following text describes a protein:
Function:
Serine protease inhibitor. Weakly inhibits trypsin (Ki = 167 nM). Does not inhibit bacterial subtilisin or mamallian chymotrypsin.
Sequence:
GQQPLCNDCFACARSLCICGDLVPQCHEGCQQCEKVDTGKPLYQCRSFEDYQCAN
The following text describes a protein:
Function:
Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
Subcellular Localization:
Periplasm. Note=Is capable of associating with the outer membrane.
Domain:
The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.
Sequence:
MTKPFSVLLASLLVITSTVSPLASAQQSQPLDRIAAIVDEDVVLQSELDRAVRNVKSQYAGRDNQLPPDDVLQRQVLERLVLVKLQVGRAEGSGIRVSDEELNRAIASIAQQNGTSVDGLRQKLAADGMGYADFRASVRDEIIVQRLRQSFAQSRISVSEGEVDTALAQQATTGSQYHLAHILVGLPEGATAEQIATGQKKVDGVKALIDKGELDFSAAAVRYSDSPNALEGGDLGWRSLDEIPNAFAQLIRDMQPGQVAGPLRGPSGFQLLKLVEMRDANAGGEKKVLTEYNARHILVRIGDNQTEAQAKAKIDTLRARIVGGADFQATAKESSEDTNSRGQGGDLGWFPADAFGPDFGKQVEGLTDGAVSEPFRTQAGWHIVQRVGTRQTDVSAENQRAQIRETIGRRKLEEEYNRYLQELRGEAFVSFRTGDRADADATAAPEPAAAPAAPTPPPAQPTR
The following text describes a protein:
Function:
Possesses 5'->3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Degradation role is enhanced when in complex with paxt-1. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle.
Subcellular Localization:
Nucleus.
Sequence:
MGVPAFFRWLSKKYPSIIVNANEERQRDVNGEKIPIDCSQPNPNFQEFDNLYLDMNGIIHPCTHPEDRPAPRNEDEMFVLIFEYIDRIFSIVRPRRVLYMAIDGVAPRAKMNQQRSRRFRASKEMAEKAMDIENVRERLAAEGLPLPPKKAPEEHFDSNCITPGTPFMARLADALRYFVHQRLTTDPAWAKIQVILSDANVPGEGEHKIMDYVRRQRASPSHDPDTVHCLCGADADLIMLGLATHEANFNIIREEFVPHQQRPCELCGQYGHELKGCTGLDATEKGADEADPVNKEKNFIFLRIPVLREYLERELAMPNLPFKYDFERVIDDWVFLCFFVGNDFLPHLPSLEIREGAIDRLIKLYKDMVWKLNGYLTKDGDVNMKGVQQIMVGLGSVEDEIFKRRQQNEERWKEREAAKKQRTGDWQGRRPQRPSYTPGDNSLIAPGGGGRNLTGEQTRAMARDDRVQAMDFSENEKAAKRMKAMLKGVGEKEEEEKAEAPSRKRKAEESVAKAHREAEQEEEVDPEPVDEVRLYEDGWKERYYQSKFCIEGDDIDFRREVAWAYVRGLCWVLKYYYQGCVSWDWYFPYHYAPFASDFDTVAQYVPDFDLDTKPFKPLEQLMSVFPAASKQHLPTEWQTLMTSSDSSIIDFYPVDFKIDLNGKKFAWQGVALLPFVDEKRLLRTLKKVYPTLTDEEAARNSTGPDRLFVGSKHPAFEFLKELYADGAGEEPVQIEPAFAYGMAGAVRADSTAILPGTVFKSPVRSEECPDLQENGGIMVIYKDPSFPDGFIFPAQKLEGAKELERTLKPGDWDDRRNGQYQPMIGFTRNTGGRASLDSSGHRAIQHEVGMGGGRNAPGGGQWERREGAGSDWNGGGGGGRGGYGGGGYGGGRGGGGGGGRGGYGGNYGGGGGGGYQQQMRHSDGGWAAQQGGGGRGGYGGGGGYGNQGGGGGGYGNRGGGYQGGGGRGGYGGQNDSWRGGNGGGRGGRGGGGGYGGGQNGGQQGGNQGNRPAWRY
The following text describes a protein:
Function:
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. Required for the development of GABAergic neurons.
Subcellular Localization:
Nucleus.
Sequence:
MSDRLKERKRTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQSSGKLEKAEILEMTVQYLRALHSADFPRGREKELLAEFANYFHYGYHECMKNLVHYLTTVERMETKDTKYARILAFLQSKARLGAEPTFPPLSLPEPDFSYQLHAASPEFPGHSPGEATMFPQGATPGSFPWPPGAARSPALPYLSSATVPLPSPAQQHSPFLAPMQGLDRHYLNLIGHGHPNGLNLHTPQHPPVL
The following text describes a protein:
Function:
Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
Sequence:
MSSAEEEVHHDLEIQEVDAGSQEKATIPVNKLKKGGYVLIEGRPCRVVDITKSKTGKHGHAKAGIAGTDLFTGRRYETHLPTSHEIEVPFVDRSDYGLINIDDDHTQLLTLDGTLREDVDLPPEGNEMRQRVIDLFNQCVNTNDQVVVTVLSSNGENLIVDCKKSTN
The following text describes a protein:
Function:
Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The ARID domain mediates the interaction with DNA.
Sequence:
MVSDLRSWKKGLQAVPLKPGVLKELGKNGQREALHKYRESTLNSGLNFKDVLKEKAELGEDADDKKVLVLSYPQYCRYRSIIARLRERPSSLLTDHVVLALGGIASLTNSTQILYCRDTFEHPTLVENESVCDEFAPNLKGRPRKKKLSISQRRDSQSGGARESNGVEGKTLVKMRADSKSGVSKPRNPSTGSCKRVQSENKPKGDGGDECRTDEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYEVITARRQWKNVYDELGGNPGSTSAATCTRRHYERLILPYERFTKGEEDKPLPPAKPRKQEGSVQESIIKAKMMPIKRPKDEQKTPRGDKDASAKVLELGMEDMEELQEKQNSQQLQAPTQTDRDPNSPLTEDDEGVLVIKDEDQPVLHNAYEHANGGLLPSLPQDGAQLKSEDCDAFPVAAVPLHHGHPLPNSHTSDQWKHGILEYKVPPSALANVEQSRPKEGQNQVVMVLPTLQQKPVTSPEIPPERVEPLKKEESCFNFNPLLYPRGNPGIMSPLAKKKMLSQVSGTGLLNNYPYGPPPPLVSRRLSSSGTEVSSAGQSSSQVSSSVETSIVIKRPSVIQHAQSFKSRGSEDRRSSTEGSQKDGCSEGEPVHHSQTLIREPYLKRVDPHSSMEKSAEMPRPGQAPSFLSEFYSSPHLHNLCRQTEHHLSKEQISKYLSRDVYTRDSETAQGFPPSQHPDNVGLNFSARLSQKEKGPPPERVTEEQPTDLSLPKSSPLKLPLSTSTLGGIPHAAIQQDIKNSPHFQAGNSQSSSVDYHPRACRVPPMTVSASKKVTESHSKVLEKTPNSRGEESMGFKIDEMSRPILSTKSSPQNICTARPLKRNIEDLENGPTEKKIRAVTPLHCSTQRDLPGKPRTPEADSESVKPAEPAVHINSYTSEGHKIPLHSHLFQGLYPGTFVSQVQDMCESLGSHVTPSYSHPLQYLKNQAVLSPLMPPFAIHSLMMQRQFLAANPAHMYRHQVGTSYGDILHPGLYPMSALHPQPAFSPPQLSSVHPSTKLS
The following text describes a protein:
Function:
May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MAVPWEEYFRLALQEKLSTKLPEQAEDHVPPVLRLLEKRQELVDADQALQAQKEVFRTKTAALKQRWEQLEQKERELKGSFIRFDKFLQDSEARRNRALRRAAEERHQAGRREVEALRLWTQLQELRREHARLQRRLKRLEPCARLLEQALELLPGFQEVPELVARFDGLAETQAALRLREREQLAELEAARARLQQLRDAWPDEVLAQGQRRAQLQERLEAARERTLQWESKWIQIQNTAAEKTLLLGRSRMAVLNLFQLVCQHQGQPPTLDIEDTEGQLEHVKLFMQDLSAMLAGLGQAEPAAPAS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MTTLPNNTQSNDYYLINPENIYQSPKPTPKDNLIKLYGLIPVTKSLARTNPDGSKGVKLRKSYKNHIQDLPGKHQISPAKPIPPGLLDPSIEQHPDIIKPLDPELLNKALKFDRTPINGIPGFNSSDLAINDQQTLMRGDDMGEDEHGKKIKRKKKIQNGADPKRQHI
The following text describes a protein:
Function:
Beta-glucan associated cell wall protein involved in cell wall structure. May serve as cross-linking or coat-forming wall protein.
Subcellular Localization:
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP).
Sequence:
MASFLKISTLIAIVSTLQTTLAAPPACLLACVAKVEKGSKCSGLNDLSCICTTKNSDVEKCLKEICPNGDADTAISAFKSSCSGYSSQSSSSESESESASSEESSASASASASSSAGKSSNVEASTTKESSSAKASSSAAGSSEAVSSATETASTEESSSAAASASASASATKESSSEAASSTSSTLKESKTSTTAAASSSESTTATGVLTQSEGSAAKVGLGALVGLVGAVLL
The following text describes a protein:
Function:
Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MEEFRRSYSRLCRESGAEPQEAVLQQLHQLPRGRLDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAKALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQASPVRTLSPPK