lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
Subcellular Localization:
Cytoplasm.
Domain:
The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
Sequence:
MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDETSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMLQFNMQTLPKGAKQKERDRLRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPRLMKMRYLEVSEPQDIECCGALEYYDKAFDRVTTRNEKTLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGKDRYKFPNPNPFVEDDMDKNEVASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSARHVILGTQQFKPNEFANQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDDDEDDEEEEEE
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MASKYTPATLNTVHISSSVLLSLLRHTSEHYPQLFSGALLGFEDESLIDVTHGFPYPYPDQYEGGSFRSRSGGQYQKDLLENFKKLGYGIEFLGWFQSTVSGNFVTNQLIEGLAQQQLINSNAFILINNLSSVGQEVSIKALRLSTGFMNAYVDGKWKSKDLESNKISYLNIFEELNLEISNQKLVDVYLSSLSLKPSTESELDVLNLLSNQNATGQLLESLSGQVDSFNYDQNNFNYYQRQYQKEQSKIQQWKQQRKLENLERAKKGEKELDTEEWKTIFKLPNEPSRYNNMLYSSAIDVLADDILKKCDEELTKSFAIERKLTASE
The following text describes a protein:
Function:
May be a carbon dioxide/bicarbonate transporter.
Subcellular Localization:
Contractile vacuole. Membrane; Multi-pass membrane protein.
Domain:
Acidic motifs (DDEEE) in the C-terminal domain are necessary and sufficient for efficient transport to the contractile vacuole.
Sequence:
MTHNDDDHKWVTTKRKEPIFFTVILFIFQIFMIICFAALTGYDTNKNYTGSENPDEFKGGEVQERVNNFYGYFRDINIMIFFGFGFLMTFLRRYGYSALGYTFIISALVSQWSVLLNGFFEAWSHSNKHGEFPSTWEFSMDSLLQGFFCSGSVMISYGAILGRVTPLHMLIMGIIEPIFFFLNVFIGEMNLEAIDVGGGMYIHLFGSVFGLTVAWFLTDRKSKECTDNAPSYSGDNFAMAGTLFLWMMWPSFNAAIAPLGEPQFRAIANTFLSLTGSTVATFIVSRLFSHLGNKLDMVHVQNSSLAGGVVQGCIAHMNINPGGAIAMGFIAGTISVCGYLFITPKVQRKLHIQDTCGILNLHCIPGFLGSIAAIFAAIKGLNNPNMYSKVEFEQIFRAGDSQASANLIATMVSIGLGIVGGLLVGVILLQLKKIKGLKSKEYYQDSAFWILPIDYPKDVATVVALNNAATSEDTAGGDDEEEGVGKEHGAVEMGKHNRIVQPKQDNKYHKQLPSDDEEEDEFKQEPI
The following text describes a protein:
Function:
Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.
Sequence:
MEESMEEEEEEAAYEAMMDDQNHNSWEAAADGYRQPPPPPPPSSSSAAAAALPSSSASRASPPPPAAQGPPARLPLPPALPLPLPPALPPPPPDPNAILMLLKTCDPAAAAAAAAKEAAAAPSPSAAININTSTSKFLMNVITIEDYKSTYWPKLDGAIDQLLTQSPGDYIPISYEQIYSCVYKCVCQQHSEQMYSDLIKKITNHLERVSKELQASPPDLYIERFNIALGQYMGALQSIVPLFIYMNKFYIETKLNRHLKDDLIKLFTEHVAEKHIYSLMPLLLEAQSTPFQITPSTMANIVKGLYTLRPEWVQMAPALFSKFIPNILPPAVESELQEYAAQDQKFQRELMQNGFTRGDQSRKRAGEELAYNGSSACASSRGYR
The following text describes a protein:
Function:
RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells. Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds to U-rich regions (URRs) in the 3'untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during early embryonic survival (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Perinuclear germ granules, also called germ plasm or chromatoid body.
Sequence:
MATSAAFLKGDFKRTGKMELSDEQKSQMWINSVNSENKEALLAWVKETGIELVQINGQRKYGGPPPGWIGNAPVSGSEVFIGKIPQDIYEDKLIPLFQSVGKLYEFRLMMTFSGLNRGFAYARYISRRQAISAIMSLNGFEITKGCCIVVCRSTEKSELALDGLPGNFDENMLKNVLDEVTSGVSSISLHPSPTKESQVLAVVKYDSHRAAAMAKKTLCEGSPILPGLPLTVNWLKTDMRQKLRSTDKLQQTKDLSPLPLLYTDRPDLPKETLLSAVGCLNMLCQEMKLGRPVFLIKLFSVTSFGWIRFWYQVVIPTYPTPFCGYAWMIGENLELNEKYEHARQVVAMKILSALGYIPDFSLGDVTARNAL
The following text describes a protein:
Function:
Neurotrophin which may function as a ligand for the Toll-related receptors Toll-6 and Toll-7. Binds to Toll-7 and Toll-6, and probably acts as their ligands in the promotion of motor axon targeting and neuronal survival in the central nervous system (CNS). Involved in synaptic targeting of ISNb/d motorneurons and also some SNa motorneurons. May be involved in the normal development of specific neurons at the neuromuscular junction.
Miscellaneous:
MISCELLANEOUS: 'Spaetzle' means 'noodles' in German.
Sequence:
MTKSIKRPPPFSCKQVLLTYVILAYTVAAHSSPPPCGLYGAPPCQFLPAPPGQTPTCARPGKTYCEHADNYPTYLIKSLVRKWGYEAATLLVDETWEDFAAVAWHDTPVFYDPKSIFPPRDPAAQDFNGYSYQTPFGGNPQRPSGGGNPLFVSNPSTEAPTYLLYTSSGGGHRSGHRYNSQGGGTSSSGGHLYINQSDKSTPYNATLWLKRLVRDLSRKQRQPDEVQAEVVEPVNEQTEEAEEQDNPAEDHPQSKRDVSLNMDLLDIVGVEAPNPLKKRSRTKRQSPGRSTLCQTTSQFITPQAALNSRGNWMFVVNEQNTARQMVKAELCASNTCSNLCELPNGYNSRCEQKFVQKRLIALQGNGQNLYTDTFWFPSCCVCTIAAN
The following text describes a protein:
Function:
May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSYKGQGANILAKVPLSALKPAHQTPRDDNAAQYAKLERIALQQSDEIAKLEQELLDEQEKNAELQQELDEITKFLADYDLHWVGGPGPKDKTYEHGPDDMNAFQAKIDQLNRSALNTKTHLKQDNNIRRIEFEKPVVITLYNSDFTVGDSPQRPYDLPMSAQFFRDIYDGFYPSEFKDNYPDGLNLQVEDKRGKELFQGKAHKLSDNT
The following text describes a protein:
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
MSADEMVQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSPEAGGPEVQQLRGLSAPGLRLVLDFINAGGAREGWLLGRRGEPGGGAEEEEEDMDEASLLSELVEAASFLQVTSLLQLLLSQVRLTNCLELYRLAQVYGLPDLQEACLRFMAVHFHEVLCKPQFHLLGSSPPAPGDVSLKQRLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVNVRGYGAAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNFKLYAIGGQAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNLNILQYCPSADLWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPTRRGSQSEDMLTVQSYNTATRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVTLSTSLEHRVFLKYNIFSDSWEAFRRFPAFGHNLLVSSLYLPNKTET
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MRLIFIVFISICLANKTLVILERNEDQQKFSQFIELLKKNGDEVEIINKMTLFQLFENGEKKYSNVILLTPHYTFKKVSVKEFIQFIDNGGNMVITLGKKYEDGYKQLLYSLDMEVDSNGSNVVDEKHTVKIGEFEMIFSNNVHNNQNIFNQRIQNILFSGIGLYLPPSPFTSSLLKAQDSASTSLFPNVSFAQETNITLVASLQARNNARIIVSGSSLLFSNIAFDSVIEHPSLNLIKSDNKKFTENIIDWVLQRRCVIRMKNIHWEKINGVKEVDYDHQLVINDTIKVNVELEQLNQGNYVPFNVDDLQIEFKLLDPVIVKNFKRIDNGKYEVIVQTPDKFGVYTMIINYRRPFLSYLEYKETIPLRTFRLTQVDRFLTGAYPFYAACASMAVGFIVFSFIYLNQIEKKEIKQD
The following text describes a protein:
Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MTPPPPKRQKRDEYRKATAEATSQSGASDVAEIKLPKKKYYRQRAHANPFSDHHLKYPLSPAHMDWSSHYPAFVNPDPSHINLAGARRLLKDVEVVDIGCGFGGLLIGLAPLLPESLIVGMEIRVSVLEYVTTRIQALRAQQQKLRAATATATAASETPSQQQAQIDGKQANANAAADAASPAPSTDTEHMPTTLVPGSYENISAIRSNTMKFFPNFFARHQLSKIFICFPDPHFKARKHKARIISETLNAEYAYALRPGGLLYTITDVEEYHHWILRHFGVELGAEEESEEKSTSPNANANAGVRELFERVSEEELEKDECVRVMKEATEEGKKVARNKGNKYVAVFRRKTDPEWPA
The following text describes a protein:
Function:
Receptor for ATP that acts as a ligand-gated ion channel.
Subcellular Localization:
Endomembrane system. Membrane; Multi-pass membrane protein.
Sequence:
MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQLGIVVYVVGWALLAKKGYQDRDLDPQISVITKLKGVSVTQIEELGNRLWDVADFVKPPQHPSIPLANCWVDEDCPEGERGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVESGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKYCRYEPQLSPYCPVFRIGDLVAEAGGNFEDLALLGGSVGIRVHWDCDLDTGDSGCRTHYSFQLQERSYNFRTATYWWEQPGVEARTLLKLYGIRFDILVTGQVGTGRGQAGDGRWQSRQGWRRHEADSRGLRGSAQISLRQGSSGSSPWPSHWAPGQLGWAWSPLSVTCCCCMWIEKPISTGGQSMRRQRPRRQPPTLCGVSWPLHPKPNWPSALDRSQHLHPRPLLLGVRHRHQDGPVQVLTPTCQPIPEARSHSLLVESWGLGRVGPCLGISSLR
The following text describes a protein:
Function:
Probable transcriptional regulator.
Subcellular Localization:
Nucleus.
Domain:
The methyl-CpG-binding domain (MBD) functions both in binding to methylated DNA and in protein interactions.
Sequence:
MCVVKTTLIDSYAAQCWKCLKVRSIESQEDYEEIRSKTLEKFFECKRCEEPGDMVMNFDSLTMRWFQDEHSIPKTPQGLKRVLVVRTNCVKVDVYYESLAPRRKRFKSIKEVATFIEDKEEFKDMTLEEVSFAAPKRLKLKKKPVDSHSSSRNTEEDGVSRDA
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Subcellular Localization:
Cytoplasm.
Sequence:
MFPSGLIERPANWVALAGFMGTGKSRIGWELSRALALHFVDTDKLITRVVGKSIPEVFAQEGEGYFRACEREVVQRVTRLDHAVISLGGGTFIHEENRRLLLSRGPVVVLWATPETVYQRTKHSDRPLLKVEDPLSRIRTLMNEREGVYRQGTIHVHSDGRPSEEIVEEVVERLWAWRDAQAAWAALPPDYDRATS
The following text describes a protein:
Function:
Cilium- and flagellum-associated protein (By similarity). In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability (By similarity).
Subcellular Localization:
Cell projection, cilium. Cell projection, cilium, flagellum. Note=Localizes to the midpiece of the sperm flagellum.
Sequence:
MWTEKAAAMAEAQESGCRNKSSISRQTPVAGAVTEDDEAQGVFKPMDLNHVIKLLEETNKDGLEEKQLKFVKKLVQCYQNGLPLRDLAQIFKILNLCAGKIKNQPRFIESAYDIIKLCGLPFLKKKVSDEITYAEDTANSIALLGDLMKIPSSELRIQICKCIVDFYHAEPPKKHIPGYQQACSSYKIQMAEVGGLAKTMVQAVTLLENQLVEKLWVLKVLQHLSTSEVNCSIMMKAQAASGICAHLNDPDPSGQLLFRSSEILWNLLEKSSKEEILPQLSNLECLLALKEVFKNLFMRGFSHYDRQLRNDILVITTIIAQNPEAPMIECGFAKDLILFATFNEVKSQNILVKGLKLSNSYEDFELKKLLFNIIVILCKDLPTIQLLIEGSVVLALFTYVKKPEKQRTIDWSAAQYEELQLHAIATLSSVAPLLIEEYMSCQGNAQVLAFLEWCEIEDSFFSHGNSFHGTGGRGNKFAQMRYSLRLLRAMVYLEDETVNTDLCEKGTIQQMIGIFKNIISKTNEKEEAIVLEIQSDILLILSGLCEHHIQRKEIFGTEGVDIVLHVMKTDPRKLQSGLGYNVLLFSTLDSIWCCILGCYPSEDYFLEKEGIFLLLDVLALNEKKFCNLILGIMVEFCDNPKTAAHVNAWRGKKDQTAASLLIKLWRKEEKELGVKRDKNGKIIDTKKPLFTSFQEEQKIIPLPANCPSIAVMDVSENIRAKIYAILGKLDFENLPGLSAEDFVTLCIIHRYLDFKIGEIWNEIYEEIKLEKLRPVTTDKKALEAITTASENIGKMVASLQSEIIESQACQDVQNEQKVYAKIQATHKQRELANKSWGNFLARTSNAKTLKKAKRLQEKAIKASRYHERPQHAIFHPTDIKGLNTTVPSGGVVTVESTPARLVGGPLADTDIALKKLPIRGGALQRVKAVKIEEAPKKSIPT
The following text describes a protein:
Function:
Modulates blood feeding of female mosquitoes on vertebrate species by binding and sequestering different mediators involved in the host response (By similarity). Binds serotonin, noradrenaline, histamine and adrenaline. Inhibits histamine-, serotonin- and noradrenaline-induced smooth muscle contraction. Exhibits vasodilating activity.
Subcellular Localization:
Secreted.
Sequence:
MFKKLLLSVGLVWCLISLGQARKESTVEECEKNIGDSLKDRVCELRQYTPVSSDDMDKHMQCVLEVVGFVDGNGEVKESVLLELLQRVDSGVNHAANMKKCVTEASTSGSDKKANTFYTCFLGTSSLAGFKNAVDYNELLKAGKMQTSDPFDMNRVAALIKEIDDGLC
The following text describes a protein:
Function:
Essential for glycerol catabolism.
Sequence:
MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGAWVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEKLNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGALSATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGVIMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKPDIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNLQIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADAAKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
KWFEPNSKRRKKRLMTSSDKLNLHNANVGRRVYEDLTALNCVCSGLSGSCALRTCWKRHPDLRVVAAELKKLYKKARPVVLATQTRNPTRYKITTGSGRVRKLFKKELAYFNRTPDLCEPDEITGSLGTKKRECKLRSNDAGDCRRLCCRRGFYDVTKEITYTCNCQFHFCCRVTCQVCRRSETLHICNG
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM8 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).
Sequence:
MADATKNPIADLSESEQLELSKFIESEQQKVKLQQAIHQFTSTCWPKCIGNIGNKLDKSEEQCLQNCVERFLDCNFHIIKRYALEKFGFLFCWLGFSC
The following text describes a protein:
Function:
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Subcellular Localization:
Nucleus.
Sequence:
MTRKRKTPKNPQELGEAEKGKNGFFACYLLTSLCPRFKGHTYIGFTVNPRRRIRQHNGELRSGACRTKKRRPWEMVFCIYGFPTNVAALQFEWAWQHPTESVAVRQAAAAFKSFSGVANKIKLAYTMLNLPSWQSLNITINYFSTNYKVHSVGCPSLPKNMKVQICPMDELPCYCDSGDILFEERENEDAWDGEEEYERASDGSGTFEANLVELVVSSLDELPCYNGRGDNIFEGGYGETASREACNKSAVHEKYNESVNTRGTVKEAHADIIVRIAADFARSIDKTSNEHFRWFEEYDQQDQREPPSPELDHANPFPFMNLLARKASSIVTSFSKSETGDRGVLTLIDEDVSELDWQRAKKLVIDKDDEASNTCETVNVDTHSSVDAHYINKASREQFGQSEPYVMQDQREPPSPELDYAEPFGFMNQPSSKASSSIVTNFSARETRDGGVLTLIGEDASEFDWPRWKKLSCKVINAK
The following text describes a protein:
Function:
Hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance. Cannot use acetyl-CoA as substrate.
Sequence:
MKDGMRVGERFTHDFVVPPHKTVRHLYPESPEFAEFPEVFATGFMVGLMEWACVRAMAPYLEPGEGSLGTAICVTHTAATPPGLTVTVTAELRSVEGRRLSWRVSAHDGVDEIGSGTHERAVIHLEKFNAKVRQKTPAG
The following text describes a protein:
Function:
Ceramide-binding protein that may transfer ceramides from the endoplasmic reticulum membrane to the cis-Golgi network membrane, and is thereby required for the biosynthesis of complex sphingolipids. Required for survival in response to oxidative stress. Involved in the diauxic shift.
Miscellaneous:
MISCELLANEOUS: Present with 45200 molecules/cell in log phase SD medium; MISCELLANEOUS: Expression in mammalian cells increases survival under conditions inducing apoptosis.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Localizes to the interface between the cis-Golgi network and endoplasmic reticulum exit sites.
Sequence:
MLKWIKGGISAVTGMAEPEYGKDYIHSVADRVKNKQPYRETSREDFFWQAPDHTNVESVIFYFSDLKTGIFGFAQVIHSNIIGLHTASQFTFRIFDSKNPEDLNIWTSTKLENFYIEGPNFYADNLSVELSEDGESYHIQSSVCDLSVVDLHIRRLTPGAKIGDDPATYYGNNINEPWGSMRHVFWPRNACHGTIKVKKEVIPESDEEESSADEDDNEDEDEESGDSEEESGSEEESDSEEVEITYEDRTITFKEEDPAISTFIMAFQGMKPHHAAKAWNFMFFHSEKYSAVLMEFTTPKSYANTKISAGIITDDKEVLAMTTNNLVEHLNSEIDSVGWKVPKDIKITFKGINTKVKDEQLESENGTEQALQGEDEKEDEKEDEEEEEYKNVAEENKICAVVEGPLNNLVERIDVMGEIPSFVKNIVSGVAGTKPFIYQYADPKSSTLQINGGEKIHGVAWTEVTFISESDVISEESYNEA
The following text describes a protein:
Function:
May be involved in recombinational repair of damaged DNA.
Sequence:
MLRSLYIQNYALIEKLDIGFETGFSVITGETGAGKSIILGAIGLLLGQRADVKAIRRGASKCIIEARFDISAYGMRPFFEENELEYDDEECILRREVQASGKSRAFINDTPASLAQVKELGEQLIDVHSQHQNLLLNKEGFQLNVLDILAHNDDALEKYHLLYNEWKLLDRELSELTALAEQSRTDEDYLRFQLEQLEEAHLVEGEQSELEQEAETLSHAEEIKAGLYRIEQSFFSDEGGLLSFLKDNLNTLNNLRKVYQPAGELSDRMESAYIELKDISQEVSAQGESIEFNPTRLDEVNDRLNLIYSLQQKHRVQTLEELMALADQYRSKLSEITSYDDRIAELTARKEAQYERVKKQATVLTKARAAAAREVEKQLAERLVPLGMPNVRFQVEMGLKKEPGIQGEDTVNFLFSANKNGTLQSISSVASGGEIARVMLSIKAMIAGAVKLPTIVFDEIDTGVSGEIADRMADMMQEMGDCNRQVISITHLPQIAARGRAHYKVYKKDSDTETNSHIRRLTDEERVEEIAHMLSGATLTEAALSNAKALLARTS
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Sequence:
MSVRKILRMGDPILRKISEPVTEDEIQTKEFKKLIRDMFDTMRHAEGVGLAAPQIGILKQIVVVGSEDNERYPGTPDVPERIILNPVITPLTKDTSGFWEGCLSVPGMRGYVERPNQIRMQWMDEKGNQFDETIDGYKAIVYQHECDHLQGILYVDRLKDTKLFGFNETLDSSHNVLD
The following text describes a protein:
Function:
Receptor for the bacteriocin pesticin and for the siderophore yersiniabactin.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKMTRLYPLALGGLLLPAIANAQTSQQDESTLVVTASKQSSRSASANNVSSTVVSAPELSDAGVTASDKLPRVLPGLNIENSGNMLFSTISLRGVSSAQDFYNPAVTLYVDGVPQLSTNTIQALTDVQSVELLRGPQGTLYGKSAQGGIINIVTQQPDSTPRGYIEGGVSSRDSYRSKFNLSGPIQDGLLYGSVTLLRQVDDGDMINPATGSDDLGGTRASIGNVKLRLAPDDQPWEMGFAASRECTRATQDAYVGWNDIKGRKLSISDGSPDPYMRRCTDSQTLSGKYTTDDWVFNLISAWQQQHYSRTFPSGSLIVNMPQRWNQDVQELRAATLGDARTVDMVFGLYRQNTREKLNSAYDMPTMPYLSSTGYTTAETLAAYSDLTWHLTDRFDIGGGVRFSHDKSSTQYHGSMLGNPFGDQGKSNDDQVLGQLSAGYMLTDDWRVYTRVAQGYKPSGYNIVPTAGLDAKPFVAEKSINYELGTRYETADVTLQAATFYTHTKDMQLYSGPVRMQTLSNAGKADATGVELEAKWRFAPGWSWDINGNVIRSEFTNDSELYHGNRVPFVPRYGAGSSVNGVIDTRYGALMPRLAVNLVGPHYFDGDNQLRQGTYATLDSSLGWQATERMNISVYVDNLFDRRYRTYGYMNGSSAVAQVNMGRTVGINTRIDFF
The following text describes a protein:
Function:
Catalyzes the attachment of N-acetylglucosamine (GlcNAc) in alpha-linkage onto the 'hydroxyPro-143' residue of Skp1 (fpaA/fpaB). Is the first glycosyltransferase in the Skp1 HyPro modification pathway, which results in a pentasaccharide-linked 'HyPro-143'.
Miscellaneous:
MISCELLANEOUS: Present with 4000 molecules/cell.
Subcellular Localization:
Cytoplasm.
Domain:
The C-terminal 65 amino acids are required for catalytic activity.
Sequence:
MNENSIFVSIISYRDSECQWTIKNLIELAKYKENIFIGVCLQYSMNDDSDNKCFQFNFEEEYGKNQIRIIRMNHTEAKGPCYARALVQQQLFKGEKYYLQIDSHMRFVKDWDIEMINQLLQCKKPNDDNGGMVIDEKAILTCYPMGYKLPNLIPTHRFPILLVASGFGENDGFLRLGGKIVSKKLIEPCSSLFWVSGFSFSRSDIINSVPYDPNLQYLFFGEEISMSARLFTHGYNFYSPTKTLIFHLWNRDYRSTFRENNSLEIQKLEENSKKRLLILFNQNNNNINDNDDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSSSSSSSSNNNNNNNNNNNNSSSTNNNNNNNNNNDDGIKIELKYNLGKIKSLDDYSNYCGVDFKNKTINNKGKFGGYYEERETFFMNEIMEYVIKSQIGI
The following text describes a protein:
Function:
Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria. Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain. Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Plays an essential role in hematopoiesis; Acts as a co-chaperone in iron-sulfur cluster assembly in the cytoplasm. Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1. This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MAASFALFCRQCFYQSPRLYTRRITTNRYYYNRSLRSGSVRLLSSVCTKECCCSRPRTCWKCHSNLFGHADFFCPSCDVIQPPEGDANYFEIMDRPEGFRIDTEVLTKDYRDLQMKLHPDRFSLQAEEEQNFSALQSSVVNQAYRTLLKPLSRGLYLLKIHGESIEEGDISSCNAKFLMEIMEINEKIEDASNDKNIQVIEDENNAKIQRCTHDVAEAFEEGNIMAAKEHLCKLKYYTNISNQIKDRKASLLLSGDH
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MRRTRTVKRESEATSGGRDGDESARFRAVKKEKNKGVASSVRIDEPPSQEAEEEREQGVSDRRVLRSQYLALINKISDSKDDLTNVDSDKFSRIFNEFENLHQKVQKPREQIADAEAFLDIANTMLSSVKSQSVNGVSPAEFVNALVNGFGQPSQRIDTDESAPVSIKWKDLGLAVCSTVLVSCGCSTMLGPMDTELKERKKAVYRKRTKPGEGVRPDEVDDTQSEEKTDTDKNMAIMFNVLRQKKRVRLENLVLNRRSFAQTVENLFALSFLSKDGRVEIIVDKNGSHFALPRNAPAANLVASGEVTYNHFVFRFDFKDWKLMSEMVPMGEELMPHRETAVASSSGPSDFPQDSQTTPIRKLSRNRGLVVQEDTVVEDSPDVEGDGTRRRCKRKLT
The following text describes a protein:
Function:
Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.
Sequence:
MTHPRQLHKFGGSSLADPECYQRVAKILKSYSKSDDLVVVSAAGKTTNRLISFVEALSKDGRVAHETLHALRQYQSELITKLLSNEAAEPLLSQLQQEISVLGELTAPLSNAQYAWVLGHGELWSARLLAALLNQQDLPAVAQDARTFLRAEAGTQPEVDRARSYPLLKAVLAQHTQRRVVITGFMAQNEQGDTVLLGRNGSDYSATVIGALAEVSRVTIWSDVAGVYSADPRIVSDACLLPLLRLDEANELARLAAPVLHSRTLQPVAQSTMELHLRCSHQPESGSTRIERVLASGRGAKIITSLDDVLLIELSFAHHHDFQRVQEDVLQHLQRVQLQPLTYEAQPDQYRLRLAYTAEIAPGAFAALQDAAFEAEIKLKEGYDLIAAVGAGVTKNPNHCYGFYQQLNALPVEFISASESSLSLVAVLRQTPIHSLVNAIHKQLFQAQKHVAIALCGKGNIGSSWLKLFAEQKEKLEQRHGMNFELVAVVDSQTYWFNEQGINPNQVATHFQDEALPNQEQSWLKKLGALEGYDEAVVIDVTASEELAEQYLDIAEHGLHLISANKVAGSAAGNYYYQVKDAFHKIGRHWLYNATVGAGLPINHTVRDLRESGDDIMALSGIFSGTLSWLFQQYDGSLPFSELVDLAWQQGLTEPDPRCDLDGSDVMRKLVILARESGLEIEPQNVKVESLVPAELRSVSLDDFLDNSKLLNEQLAERLARAQKQGKVLRYVARLEKNGKASVGVEALEQDHPLANLLPCDNIFAIESKWYRDNPLVIRGPGAGREVTAGAIQSDLNLLASLL
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MAVGLAETPPHPEFAVANSGLSPQAGRGEEAASRSTKSAWITLIFLPRLLPSRKLSYLALASAFLRVGHLRRLLFLNGIKAFEAAARTGSFAAAGVELNVSAAAVSRMVHLLEERLGVALFERKANRLVLTQAGRAYQSGLTPIFDALASLTAQVTAPSSVRVLTIGVGHTFAMRWLIPRLSEFRNEEPDIEVRFTTGGASVPFGEDWSCGIKLGTGDWPGLVAEPLFAGDLTPVCVPRLAASLKRPADLRGPSLIRVAHSAEDWPIWLKAANLARINARGPEFQFYGQALQAAADGLGIAMGIRPYIDDDLAAGRLVAPFDLSVPKGMRWYLVYRSFQTEQRDFAAFRRWIMRAASEPAARPARRTGRTTARN