lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation.
Subcellular Localization:
Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet.
Domain:
The coiled coil domain mediates homo- and hetero-oligomerization; The MATH/TRAF domain binds to receptor cytoplasmic domains.
Sequence:
MSILNPRTSLEAGDSDDACCAAMASACCLNTKEDCDSPSTALPSGTPQSLEVEEVQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIVKSLRDAGHKCPVDNEILMENQLFPDNFAKREILSLKVKCPSQGCTETMELRHLERHLGQCQFASVECSQCQGSFPKSRLEKHMEHECGRRKIFCDNCGLAMAYEDMSGHELICPLAYVTCEYCQTNLIREQMPSHYSMDCTMAPIPCMYYEFGCTEKMQRNDLARHLQDFTQAHMRMMFQTLRSFSTTPTSHISDISFCDPNQFEPVPLSVAPAHPSHMPSHQDCSQETRNLRETIEQLEGRLVRQDHQIRELIAKMETQCTYVNELKHTIRSLEDKLLDVDGHHCNGVFIWKIKGFSGLQKTQEEEKPVVIHSPGFYTGKPGYKLCLRLHLQLPSAQRCANYISLFVHTMQGEYDSLLPWPLHGTIRLSILDQSEGAIIQDQEEVMDTKPDLLAFQRPTTQRNPKGFGYVTFMHLNTLKQRQYVKNDTLFVRCAVNIHLDVISPRREGFQPRSGDGAQ
The following text describes a protein:
Function:
Promotes slightly the tolerance to oxidizing chemicals (e.g. diamide).
Subcellular Localization:
Nucleus.
Sequence:
MHYQEQMESLMLGEERRRGNYTRDVDADADEGVNSPSSFPNSPDDSDRRSSSSSSRRGLSKHYKGKSQSFTTLAEALTVEDLAKPENPFNAKLKQRRESPHCRRLSGCGGASERNLSVHDVFLAGNDRPPRLSGNRPPPRAQTLSAAHISALLTRT
The following text describes a protein:
Function:
Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).
Subcellular Localization:
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Sequence:
MNELRMPNLVRPNRPLREPASRPLTPSRFPVPSQPDAAYTGSAAGSTGLGSPGPAIMDGSTSFGLVQPAPTAHFCHYCGQQGIFRCKGCKKTPYCSVDCQREDWKAHRHMCKSFDPETVGENMKESPDSDNVREDSLNIQRIYLKDLNATKYTKGAEIQGAVVEFNSPGRFFFLPEDPKVMEALMSITAEXQKXPSSTVGTPYVPCVGEVCSVQFSXDLNWYRGLIQTLAADQKTAHVLYIDYGNAENVPVERIKPLNIATKPYCPCAMECQXAGVVPIVDSWSTECCMTVRQLLGGKTLTIKLVDTLKNGRVHTVDIQLSIGKQLSTFLLEQGYAFAEAAAVGSAPAKKDPSALLEASMENFKRCCEGKDINEWAQPPEPLTLTIGDRFSVVVSHFQSPTDFIVQKVENAGVIQDLQLKLREHCSGVETQQDFRPAPGTVCCAQFSEDKQWYRAQVLAYSTEKSVCVGYIDFGNSEEVDLNHLRPISPALLALPKQAISCILAGVQPVEDSWSEECISTMLRMIANKTVNVEIQSAHKGKALVAIIEGEGYSEINVAELLISANYAAPADSNTLQQTEETTASAEPPASPPVCEPLVWSCVELPSDGQTVVLSTSAVTSPAEFYCCVGPTTDHQVLMELGVQLKQHCQSDSTYFVPKVGEPCCVKFSGDGKWYRAMVKELLGDVVKVNFVDFGHNMIVGKGCLRSITPKLLKLPFQAVRCWLAGVKPAGSEWSSEALLWFQNLVDGAQLLARVVSVSQQGYGVELESGGQSVAAALVSQQFAKPSGNLSKDPVRSPTTKQEDLRGGDQSQALTPASNDTQAVCEDGKSEEEPSEVATFSSAWKTAELPLNETFQPCVAAVINPTLFYLLHPIQNVDQQKLQEVMLELALHCSNYQSSSSVDTRPVPGAACCAQFSVDKIWYRAIILEVGEAEMSVVYADYGNSEKVPVSQILPIPTRLLQLPFKIIRCTLAGNEHFPVEWPPQVQQVFRSELLNVMATVQSFDGSANVLSLALPPERGGRNLAAVIQEMLHVHRKGSPLPDASQTPGSDATEPSCIKLGSTTASPDEPEDAAEPADAVTNTQESTPQEQKEMDQATSVHDLQGPGCCCQSLKKQMDRLEKMVQLLLSLQAEG
The following text describes a protein:
Function:
Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
Sequence:
MTVFEVKYEDLAGRIGTLRTRSGTLETPAFFPVINVLKKDEISIDEIRNIGFKNFITNSYILYKNNYIKDDIHKELRSEEMIIMTDSGAYQILEYGEIGITNLQIVNYQLKIKPDIGVILDLPTGNINDYDNAKKTVYETLKRAEEASEIIVKNQDNNIIWVYPIQGGRYLDLVKTSAEGLSKFEHIYNMAALGSPTVLLEKYMYDTVIDMIYTAKSNIKRGIPFHLFGGGLPHIIPFAVALGVDSFDSASYIIYARDNRYITRTRVYKLEDLEYFPCSCPICSKYTPKDLLEMNEKERTKALAIHNLYTILEEFKATKQAIKEGRLFEYLQEKAYSHPAVYSAFKRLMKYKDYLEKFDPRIRGDPKGLFLFDGNSLHRPEIIRHSRFLERYIQKKDKISIYCYDKAISDTAYDFKEKIREKIADRNESDVFIAVPFFGLIPLEISDSYPLSQFEIPNEIDEDVIDDMKTKIISFLRRNNYQKVELINCEKLGLHIDSISTSS
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MFQNKEQTESILVWEKIVSIFSIPSQNEILNFKQKSPNNIDNNLKQLFNFVKLYKLESLVLDWYFESIKKYFKSTLSNEFWKFFNNVNLAELDSSTTSGRQLKFINHQFALSINLLHKVFSFFKSNLFLFYELLFKKESYNFNFLIKKLQDLLITNIMHTTNQQTKYFNTILFMFFERDFISFTKSFYHSKKQILKDEEENNNNSKDLEFNDQQQEEEEEEEENEEESKSYIIMEMSFEDSITDINIKEDSFMDLCKKLQDLNFIVISEEIFTQILFKKVFEYIETRCKGVFEKSFLKSILEWADQVIFKWLAMILLSSTTTTKINNYNDIINNNDDDNDDDDDDENKENSLKIFNQWKKRLEFSIYENYSQQRISELFDMIVQYPDSLPSLEDLSICFQKIPIEKTMITNLKRVLHNRLLHPGANTSDIITQYISTIHAMDIIDPSGMVMEKVGKPIREYLSQREDTIRCIISSFTEESNEIYQELCNYDPQDNGGDDDSNNSLLAFGNCDLYVDEGDNFSSIDDFKFWIPNKIDGSSTTISIGNAKANNNNKKKKKKDTISHLVNIYDGIDLFINEYRSMLSDRLLSVVDFDLDKEIKNIELLKLRFGDSVLFNCEIMIKDMVDSKRLNLQIKNSQGVNNNNNNNNNNNNELKEFETLILSQLFWPTLKGDEFKYPKSIEKKMQIYSKEYERIKTPRQLIWKQHLGLVDLDLEIGNNIQSFQVSPIHATLIMLFESDDGDDDDEKELTLEYLSKQLEISKDLVKKKLIFWLNNQIIKETSHETYKINNKEKEEQKQRQQQIENDDQDESSSDDDDDDNNIVVEEEEEEKSTSAKEKEEQMRVVESFIIGMLINFKTLPLERIHSMLTMFNSELYTSTIHELKAFLSKLVNEEKIELVGNDFKIKK
The following text describes a protein:
Function:
Involved in development during embryogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MPRPGRSTYGDQKPPYSYISLTFMAIQSSQEKMLTLSDIYKFIMDRFPYYRKNTQRWQNSLRHNLSFNDCFIKIPRRPDRPGKGSYWALHPACGDMFENGSFLRRRKRFKLPRQIKDATAVALAELKHYETVSQNAIQEQAKMRLTALAAAPSHLQGHHADPLRHGTTLPFIKQPFSIENIIAPEGKHFSGVLPSPSYPSPHPQHLRSLPPFPCSLPYATTASWHSTYSSLVAAAAGRQDLNGLLCGAKMPPGHYPLAGVVPVSSSGSAMPFSLPSLPLKPPTLLPAFQFPGMSPEQSLFSVSAAHMTSQMASATASLPCTPPRPDSASSDVSCTSLDVVSDELANDLC
The following text describes a protein:
Function:
Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.
Sequence:
MDLIAEAEDRAKKNMETLLDNNIPPYAILSHTWGSDEQEVNFEDINSGNGKEKTGYEKLQFCGKQAAYDNIDYFWVDTCCIKKTSDSELTESLNSMFRWYGKARKCYVYLSDVEVVQNGVEQPQSVWEGRFRASRWFTRGWTLQELLAPISIEFFSRDCCRIGDRESLKLIIYEITGIAIEALQGVPLSKFSVDDRMKWAENRISTREEDAAYSLLGIFEVSMSVIYGEGRDNAFRRLNGVIEPSLDKRCLIDLFITDPRKDKQRIEELKGGLLFKVYEWVFQNTEYQQWYNDQSNRLLWVRGDPGKGKTMLLCGIIDEIRTSNNYALAYFFCQSNVDTINSAISVLRGLIYMLLDEQPSLIRHLQKEYEVPGKQLFEGINAWVALSNILKNILHDKSLKPIILIIDALDECEKDMVKLLRLIVSSLAEFPRIKWLVSSRNSLGIEEVLGPVEERTSLSLELNSHTISIAVDWYVRDRVEKLARTKKNIKRNRKTVESYLLENANGTFLWVALVCQNLEELRFFTTSMLQDYYPRELDPLYERMLQQILNIKEHGVTELCLQLMAIVVVAFRPITLCELPRLIGSEIDLEEIIQLCGSFLVVRNQSIFFVHKSAKDFLSENAAETIFPNGIGKVEKAPELSAYIHDAKRFVLYNRVGIEQAPLQIYCSALSFAPENSIIRKTFQKCIPSWIYKISRVRSNWSAALQTLEGHSNWVRSVAFSPDGTKVASGSDDRTIRLWDAATGESLQTLEGHSNWVRSVAFSPDGTKVASGSDDRTIRLWDTATGESLQTLEGHSDGVTSVAFSPDGTKVASGSYDQTIRLWDAATGESLQTLEGHSNWVSSVAFSPDGTKVASGSDDRTIRLWDAATGESLQTLEGHLDAVSSVAFSPDGTKVASGSDDRTIRLWDTATGESLQTLEGHSDGVTSVAFSPDGTKVASGSYDQTIRFWDAVTGESLQTLEGHSHWVSSVAFSPDGTKVASGSDDRTIRLWDTATGESLQTLEGHLDAVYSVAFSPDGTKVASGSGDWTIRLWDAATGKSLQTLEGHSNAVYSVAFSPDGTKVASGSYDRTIRLWDTVTGESLQTLEGHLDAVYSVAFSPDGTKVASGSGDWTIRLWDAATGKSLQTLEGHSHWVR
The following text describes a protein:
Function:
Transcription factor acting downstream of the MPS1 MAP kinase (MAPK) cascade during conidiation and plant infection. Required for overcoming plant defense responses and the differentiation of secondary infectious hyphae in live plant cells.
Subcellular Localization:
Nucleus.
Sequence:
MGRRKIEIKAIKDDRNRSVTFLKRKGGLFKKAHELSVLCSVDVAVIIFGNNKKLYEYSSSNIRDILQRYTYHGGPNEHKGPSDFNGGADDDDDDDENGTNSQGEQHMMYQPNPPVSYPFLRHTSLSDSPPVPNGAFGPQPGHQMSRAHTPQPPFVARPPSVNDIRRLRPGQPVRPAGVAQELQNRSAFVPSPPIYNSQPPASMAPTHGLPTQLHPQYPFQPSQPPAHSMQQFEDQRRSPLPPTFVSQPPPHPAHRHSTSPPELLQPQIPQQQVHRHSASPQVHQAQLPQQPQRLPSANMSPPPPQPAQPPQQQQQQHRHQQQQPQSMPNQNLQPPAPPKPESMERPRRLIPALNTSVKNPGQGSVFTPIEPENKSILSQHFAAFRPEIKSESPNNRSQSVDGGNVSKPNTSTPSIQLSSAHGQGSAQRTNSLTVISQSTLPPPSRPQHLRVGGGPLRPRLKVQIPDDSDSGSAAGSASSPRVTTTTDSAPQPLKTGSVLPPPSPSASNLPSAGATGPPNPFAPRSTIQHNNNMNIDTPVSALPSRFLGDLLPSPSRFYPEWGYGISAESNTLPSPLNFATPVNGTGPSFLRDDPTPLKRKSPETKSTGPENDTGNNQDAKRMRLES
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MKLSIAILGSGSIGTYIGCKLLAAGNPVTFYGRARIQNELKTFGAKITDYTNQEILLPPNTISFTTSFSDISNADVFLVTVKSKDTKDLAKELNGILEKRQNRSQTIPIVVSFQNGVRNAEILKEELRDLPVEVFAGMVPFNVVSKGNGHFHRGTSGNLVIEDSKSSQTLVKVFKRAGLSINTHKNILGILWGKLIFNLNNSLNALSGLTLKAEISKRGYRKILSKLMKESLEILRFAEIRPIRSGKMIPSLAPIILNLPDFLFFRIASGMVKIDPQARSSMWEDLVKKRPTEIDSLNGEIVKLADVMGHPAPFNREIVRLIKEAESNPQILNLSPEELAKKLKIKLT
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MHNVRKQKYSAEQLAEKKQLEKGKINAYNGLSTQVNQFRREGKHDKEALDLNTKLIKINPEFYTMWNYRREILKTGILPNLEDKDDFLDGELKFVQECLMRFPKTYWLWNHRKWCLETAAKPDWKKELAMVTYALAKDERNFHAWNYRRYVLAKYEETLPEAHRGAVKPKEFEFTEEKINKNFSNFSAWHQRSKVIPELMEETRQGKCTDEKLVKRLSDPKTFFGSELDYVKNAIFMDPNDQSVWLYLRWLLTKPEIIYPDISTEYHIEVVESTIKEIAELYEDEKDCRHCIYWIVFYTIMLYELKKQRIPEAVGRTLTKHIGDLKEKDALRKGQYEDWEKVVVSAH
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Miscellaneous:
MISCELLANEOUS: A cysteine residue is required for ubiquitin-thioester formation.
Subcellular Localization:
Membrane; Peripheral membrane protein. Cytoplasm. Note=Predominantly found at the cell surface of the polar regions.
Sequence:
MENIRFEVQLTILHVEGLWKNGLLRSLKPYLLISVDDDQFIKTNVASGTLRLSWGFTQKLTVSPQSIILLQLFDEKQKNETSDGFVGLGAAVVNSFLPFNNPKDDYKTRITLRSPSGSYRGSVVCLFKRSKFLPEELPADKSQICTDIIDDASGCAWETRIDEFGHVYYLKSPQLSVISAISHEKLENLTPKQLKEVFSQFLFNNQSKSSLKINLEYKVIKHLLEHYPLALSVRQQVAVEKGPLPAGWEMRLSEDYHVYFVDHSTKTTTWSDPRDNVVASDSVSENTDSIQQINDEYQRKIAYMYDRPEMAVNDAQLQLKVSRATTFEDAYDIISKLSVSDMKKKLLIRFRNEDGLDYGGVSREFFYILSHAIFNPGYSLFEYATDDNYGLQISPLSSVNPDFRSYFRFVGRVMGLAIYHRRYLDVQFVLPFYKRILQKPLCLEDVKDVDEVYYESLKWIKNNDVDESLCLNFSVEENRFGESVTVDLIPNGRNIAVNNQNKMNYLKALTEHKLVTSTEEQFNALKGGLNELIPDSVLQIFNENELDTLLNGKRDIDVQDWKRFTDYRSYTETDDIVIWFWELLSEWSPEKKAKLLQFATGTSRLPLSGFKDMHGSDGPRKFTIEKVGHISQLPKAHTCFNRLDIPPYNSKEELEQKLTIAIQETAGFGTE
The following text describes a protein:
Function:
Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB).
Subcellular Localization:
Cytoplasm.
Sequence:
MSEKSASNNKAEFKRQSSPFREIISADHPIYKPAKGRYWLYVALPCPWAQRTLITRALKGLAPIIGCSVAHWHLDDKGWRFLEEGDGKTNERHWFDIAGGISSVNLNTSTPVANIPNNAHRLLVDGTDEPHYGYKRLSDFYFKTKPDYKGRFTVPVLWDLETCTIVNNESSDIIGIMNSAAFDEFVGEEYRQVRLVPRSLEAQITEFNSWVYDKINNGVYKAGFAECAEVYEREVTSLFQYLDKLENLLDKKYTDLEAEYGKNNKDKILDRYFAIGDTLTEADVRLYPTIVRFDVVYHQHFKCNLATIRDDYSRIHTWLKNIYWRHEAFQRTTDFTHIKLGYTRSQPRVNPIGITPLGPKPDIRPP
The following text describes a protein:
Function:
L-tryptophan decarboxylase; part of the gene cluster that mediates the biosynthesis of psilocybin, a psychotropic tryptamine-derived natural product. The first step in the pathway is the decarboxylation of L-tryptophan to tryptamine by the decarboxylase psiD. 4-hydroxy-L-tryptophan is accepted as substrate by psiD as well. The cytochrome P450 monooxygenase psiH then converts tryptamine to 4-hydroxytryptamine. The kinase psiK catalyzes the 4-O-phosphorylation step by converting 4-hydroxytryptamine into norbaeocystin. The methyltransferase psiM then catalyzes iterative methyl transfer to the amino group of norbaeocystin to yield psilocybin via a monomethylated intermediate, baeocystin. 4-hydroxy-6-methyl-l-tryptophancan also be converted the decarboxylase PsiD, kinase PsiK, and methyltransferase PsiM into respectively 6-methyl-norbaeocystin, 6-methylbaeocystin, and 6-methylpsilocybin.
Sequence:
MQVIPACNSAAIRSLCPTPESFRNMGWLSVSDAVYSEFIGELATRASNRNYSNEFGLMQPIQEFKAFIESDPVVHQEFIDMFEGIQDSPRNYQELCNMFNDIFRKAPVYGDLGPPVYMIMAKLMNTRAGFSAFTRQRLNLHFKKLFDTWGLFLSSKDSRNVLVADQFDDRHCGWLNERALSAMVKHYNGRAFDEVFLCDKNAPYYGFNSYDDFFNRRFRNRDIDRPVVGGVNNTTLISAACESLSYNVSYDVQSLDTLVFKGETYSLKHLLNNDPFTPQFEHGSILQGFLNVTAYHRWHAPVNGTIVKIINVPGTYFAQAPSTIGDPIPDNDYDPPPYLKSLVYFSNIAARQIMFIEADNKEIGLIFLVFIGMTEISTCEATVSEGQHVNRGDDLGMFHFGGSSFALGLRKDCRAEIVEKFTEPGTVIRINEVVAALKA
The following text describes a protein:
Function:
Viroporin that forms a homopentameric ion channel displaying low ion selectivity. May play a role in virus morphogenesis and pathogenicity at various stages of the viral life cycle. Accumulates at the membrane of the Golgi apparatus in infected cells and may facilitate virus release by modifying the secretory pathway. May enhance host membrane permeability and disrupt cellular ion homeostasis, which can be sensed as damage-associated molecular patterns/danger signals, triggering NLRP3 inflammasome activation and inflammatory immune response. Also inhibits host TNFA-mediated signaling pathway and may delay apoptosis, allowing time for the virus to replicate.
Subcellular Localization:
Host Golgi apparatus membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein. Host endoplasmic reticulum membrane; Single-pass type II membrane protein. Virion membrane; Single-pass type II membrane protein.
Sequence:
MENTSITIEFSSKFWPYFTLIHMITTIISLLIIISIMIAILNKLCEYNVFHNKTFELPRARVNT
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MDLSTSGSLPCHLPLSLLTNLQTPPIDTSFSSPPATSSSSLLSPSPSSAFRPVVPKSLMNPQPAMDTFYMSAIQSLVVSTTNDDQYSEHGALEGSKSLAKDENASTSAGTILCQVCSDKASGFHYGVFACEGCKGFFRRSIQQKITYRACTRAEDCLILRNNRNRCQCCRLKKCLAVGMSRDAVRFGRVPKREKARMFEEMQKTNVQSQRDQIAIQYENLTEVMHKINQAFGTLQATLEKCTGPIYTDRCPITSNFIVIPLKAAIDFANSIPAFLSITQTQRVHLLQNSVFDVMLLASASASTSQHFPPGGLTYDQSSANPIIPQAIQSISARIRQLPPQTVPILTAIAVCQADLLPESQQPMLLAERLWCVLGKLGGIQSLATAPSLLADVRTLRQWHSDRLRQMSQISQHFSQNLLIAPVAAAAPVLLPPAFLSPPASATSTSSSSVKSEFIERHPSIASLLERPRRISSSGAQEPLNLSLPHVRHQVKRDVDSDEQLEEMKVSPVPTTLSE
The following text describes a protein:
Function:
Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSSVKQSAQAATSDVVDTAKNATAETVTAATDFLHTPAVRAALPFINGGLSGMVATTVIQPIDMIKVRIQLAGEGKAGGPKPTPLGVTRDIIASGKAMDLYTGLSAGLLRQAVYTTARIGCFDTFMSRLSARAKEKGQSVGFKERASAGLAAGGLAAMIGNPADLALIRMQSDGLKPVAERKNYKSVIDALGGIARNEGVAALWAGAAPTVVRAMALNFGQLAFFSEAKAQLKARTQWSSKVQTLSASAIAGFFASFFSLPFDFVKTRLQKQTRGPDGKLPYNGMVDCFAKVAKQEGVFRFYRGFGTYYVRIAPHAMVTLLVADYLGWLTK
The following text describes a protein:
Function:
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Domain:
Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
Sequence:
MSLAWEDFVEEVKQRVNIVDVISRYVNLKKTGKNYVGLCPFHQEKTPSFYVSPDKGLYHCFGCGAAGDVFSFLINYRNLTFREALEELAREVGLELPKKDERISAEANIFLEINKAVATFYHIYLNSKYGAEGRLYLKKRGVSSEIQEKFLLGYAPLNPTLLLKYLEKKGFSKDDILKAKVLYFIKDEWKDPFAGRVVFPIMNPRGKVIGFGGRTLTGEEPKYLNSPESDLFSKGKNLYALYQAKESIKKEGEAILVEGYMDAISLHQAGITNAVASLGTAFTSHQAKLLKSYTNKVILGYDQDSAGYQAGKRALSLLELEGLEVYWLSLPHDVKDPDEFVQKYSKEEFLRFVKESKTSLDFLIENTLNLPMNFKEKLEEIIEILTSSILRSKNILVQQEKIKQYLPVISRKLGVPEEGLQREIQKRIFSDRSYRNDVKIEITRYFGVSKTEEVLLGLILLKTNNSQIRNMSPEDFSFPLYQEVLKKWRIWEGTLEEFLNLWDEDKRVLIDRAISSGEEFINQEEVIPFLWDHFQKLRIKKEINKLIEELSKVEDPAKEKELMEEIYFLRSLLEVKD
The following text describes a protein:
Function:
Cell surface-associated calcium-binding protein which plays an important role in adhesion and pathogenesis. Contributes to the resistance to killing by innate immune components in blood and thus attenuates bacterial clearance by interacting with host complement factor H/CFAH and modulating its activity. Also inhibits bacterial opsonization and killing by interacting with host complement regulator C4BPA and thus inhibiting classical complement pathway activation.
Subcellular Localization:
Secreted, cell wall; Peptidoglycan-anchor. Note=Anchored to the cell wall by sortase A (By similarity).
Sequence:
MINRDNKKAITKKGMISNRLNKFSIRKYTVGTASILVGTTLIFGLGNQEAKAAENTSTENAKQDDATTSDNKEVVSETENNSTTENNSTNPIKKETNTDSQPEAKKESTSSSTQKQQNNVTATTETKPQNIEKENVKPSTDKTATEDTSVILEEKKAPNNTNNDVTTKPSTSEPSTSEIQTKPTTPQESTNIENSQPQPTPSKVDNQVTDATNPKEPVNVSKEELKNNPEKLKELVRNDSNTDHSTKPVATAPTSVAPKRVNAKMRFAVAQPAAVASNNVNDLIKVTKQTIKVGDGKDNVAAAHDGKDIEYDTEFTIDNKVKKGDTMTINYDKNVIPSDLTDKNDPIDITDPSGEVIAKGTFDKATKQITYTFTDYVDKYEDIKSRLTLYSYIDKKTVPNETSLNLTFATAGKETSQNVTVDYQDPMVHGDSNIQSIFTKLDEDKQTIEQQIYVNPLKKSATNTKVDIAGSQVDDYGNIKLGNGSTIIDQNTEIKVYKVNSDQQLPQSNRIYDFSQYEDVTSQFDNKKSFSNNVATLDFGDINSAYIIKVVSKYTPTSDGELDIAQGTSMRTTDKYGYYNYAGYSNFIVTSNDTGGGDGTVKPEEKLYKIGDYVWEDVDKDGVQGTDSKEKPMANVLVTLTYPDGTTKSVRTDANGHYEFGGLKDGETYTVKFETPTGYLPTKVNGTTDGEKDSNGSSVTVKINGKDDMSLDTGFYKEPKYNLGDYVWEDTNKDGIQDANEPGIKDVKVTLKDSTGKVIGTTTTDASGKYKFTDLDNGNYTVEFETPAGYTPTVKNTTADDKDSNGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKDVTVTLQNEKGEVIGTTKTDENGKYRFDNLDSGKYKVIFEKPAGLTQTVTNTTEDDKDADGGEVDVTITDHDDFTLDNGYFEEDTSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSTTKDHHNKAKALPETGSENNGSNNATLFGGLFAALGSLLLFGRRKKQNK
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRNGTITTFILLGLTDDPELQVLIFIFLFLTYTLSITGNLTIIILTFVDPHLKTPMYFFLKNFSFLEISFTSAVIPRYLYSIATGDNVITYNACVIQVFFTDLCGVSEFFLLAAMSYDRYVAICKPLHYVIIMSNSVCRILNICCWVAGLCIIIPPLSLGLNLKFCDSNIIDHFGCDAFPLVKISCSDTRFMEWTVIICAILTLNMTLTCVVLSYAYIIKTIFRFPSVQQRKKAYSTCSSHMIVVSITYGTCIFIYMNPTAKEKVTINKVVSLLIFSISPTLNPFIYTLRNNQVKKAFEDSIKRIALLSTK
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MPPEESVSKSLLDKPLQQLTEDDISQLTREDCRRYLKLKGMRRPSWNKSQAIQQVISLKALLETATDSDAGTRKKLYIPRSETKLHHVQRGKNTDEEFIELAEETVPDGRTLQDKADLSGDASPTLVAAIDKSAPSRTIGSVDTSAGQMTIFYSGKVNVYDDVPADKAQTIMCVASSSLCVPSETPLNATVAARHSTCCLQLATTKLRPISDMVLLPTIQTEAVENPSSRKASVQRYLEKRKDRFKCKRKVEITSTVSLDIHLNDRTGALSPMEHSSRSDLCFPPLIRLSSAPTPSGPIEETIQMNATFSSGPNDRGDVVYPLNNLTIFVVIVLSNVQH
The following text describes a protein:
Function:
Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis. Along with Yp2 and Yp3, and their receptor yl/yolkless, required for maintenance of microtubule plus-end orientation towards the posterior pole of oocytes. Involved in polarized localization of germ plasm components, such as osk mRNA and vas protein, to the oocyte posterior cortex. Receptor-mediated endocytosis by yl/yolkless is crucial for actin reorganization, mediated by osk isoform A/Long, required to anchor germ plasm components to the oocyte cortex.
Subcellular Localization:
Secreted. Vesicle. Note=Yp1 secreted by fat body cells is taken up by oocytes via clathrin-mediated endocytosis and stored in endocytic derived lysosome-like vesicles called yolk granules.
Sequence:
MNPMRVLSLLACLAVAALAKPNGRMDNSVNQALKPSQWLSGSQLEAIPALDDFTIERLENMNLERGAELLQQVYHLSQIHHNVEPNYVPSGIQVYVPKPNGDKTVAPLNEMIQRLKQKQNFGEDEVTIIVTGLPQTSETVKKATRKLVQAYMQRYNLQQQRQHGKNGNQDYQDQSNEQRKNQRTSSEEDYSEEVKNAKTQSGDIIVIDLGSKLNTYERYAMLDIEKTGAKIGKWIVQMVNELDMPFDTIHLIGQNVGAHVAGAAAQEFTRLTGHKLRRVTGLDPSKIVAKSKNTLTGLARGDAEFVDAIHTSVYGMGTPIRSGDVDFYPNGPAAGVPGASNVVEAAMRATRYFAESVRPGNERSFPAVPANSLQQYKQNDGFGKRAYMGIDTAHDLEGDYILQVNPKSPFGRNAPAQKQSSYHGVHQAWNTNQDSKDYQ
The following text describes a protein:
Function:
Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.
Subcellular Localization:
Cytoplasm, perinuclear region. Golgi apparatus, Golgi stack.
Sequence:
MAPGAADAQMVPTDPGDFDQLTQCLIQAPSNRPYFLLLQGYQDAQDFVVYVMTREQHVFGRGGPSSSRGGSPAPYVDTFLNAPDILPRHCTVRAGPEPPAMVRPSRGAPVTHNGCLLLREAELHPGDLLGLGEHFLFMYKDPRAGGSGPARPPWLPARPGAAPPGPGWAFSCRLCGRGLQERGEALAAYLDGREPVLRFRPREEEALLGEIVRAAASGAGDLPPLGPATLLALCVQHSARELELGHLPRLLGRLARLIKEAVWEKIKEIGDRQPENHPEGVPEVPLTPEAVSVELRPLILWMANTTELLSFVQEKVLEMEKEADQEGLSSDPQLCNDLELCDEALALLDEVIMCTFQQSVYYLTKTLYSTLPALLDSNPFTAGAELPGPGAELEAMPPGLRPTLGVFQAALELTSQCELHPDLVSQTFGYLFFFSNASLLNSLMERGQGRPFYQWSRAVQIRTNLDLVLDWLQGAGLGDIATEFFRKLSIAVNLLCVPRTSLLKASWSSLRTDYPTLTPAQLHHLLSHYQLGPGRGPPPAWDPPPAERDAVDTGDIFESFSSHPPLILPLGSSRLRLTGPVTDDALHRELRRLRRLLWDLEQQELPANHRHGPPVAATP
The following text describes a protein:
Function:
Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAVFAIATTLQLFQLLAAASLMLLSDTSAASSPLSGSGIRCGNISLPYPFGVAAGSYREGFKLVCNETYDPPKLFLGNTGVEVLEISVQDGTIHIDGGILSVDMDMMISNPTSSLNFLDWTVPLNGNLYTVSSSNQVAALGCGFLLVWTVPEEGNPGEGASTTCSSSCAAGGHSVVATDGTCDCSGVGCCSVSKLFGHYNTFSFGFGMNDNVRYTNMTTLVVVDPEWWSEQENIMAVQKAVSSHSSILGASGVRHTVPWIQVRTVVNWVFSNSSCARDRNTGDYGCLSDNSECHDSELTSVDGYNCMCQPGFQGNPYIQDGCQDINECTSPGEHSCFGQCINFAGSYQCTCPRGTSGDPRKPNGCSSTKRKFPGLLVVIAIFSGIAVAIFIFTVVFVKRKIRVWKARKSREFFFRQNRGLLLRRLVDKDIAERMIFTLEELERATNKFDEARKLGGGGHGTVYKGILSDQRVVAIKKSKIVVKREIDDFINEVAILSQVNHRNVVKLFGCCLESEVPLLVYEFISSGTLSDHLHVATPLSLPWKERVRVALEIARSLAYLHSEATISIVHRDIKSSNILLDERLIAKVSDFGASRDIPIDQTGVNTAVQGTFGYLDPEYYHTWRLTEKSDVYSFGVILVELLTRKKPFDCMPSPGASLTAEFILLVNQDKLSEILDPQVTEEGGQKAKEVAAIAVMCLSLHGEDRPIMRQVETRLEALLTEVHGHENIVETDGLILNDQQSNDNARDNISRRCSMEEEFLCSMSLPR
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Subcellular Localization:
Cytoplasm.
Sequence:
MKPILLQGHERSITQIKYNREGDLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDSNEPYMKIPCNDSKITSAVWGPLGECIIAGHEGGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKRGRCRKARHRSDQTAPTASPPQTPATAGTGGPAATRNPGRGEKWVPRAWGGRGRRPSGHSAAGRGGRPGEGAERWAQESRVLEGGI