lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces. The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules. The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase. In the complex, it mediates interactions with microtubules. It also stimulates AURKB/Aurora B catalytic activity (By similarity). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MNHCELEEVTQHINNKISMIKRLLELRAVAKDPDKRGTLLKIGQEVSAINELLDRFEKYVGKQRDLLKHLKDLEGFFQEDEQDAYHLKNNTPPHMPKRGQQAAPQGGGQVAVQSRQTDAPAAPQEQGPPRKTQRNQIKEMEFITVPEFDSIPPYMKGRVTYDQLNAAVQSINTAVTSKYKILHQPVKTLNNVSRSLQQRFKDQETKDTKGHFFVVEQDIKEFAQLKVDKRFVGMLNMLRHCQRLKEVRGGGLTRFILL
The following text describes a protein:
Function:
Involved in the biosynthesis of capsaicinoids and capsinoids natural products, pungent alkaloids synthesized from phenylpropanoid intermediates in the placental tissue of chili pepper fruit acting as repellant on herbivorous mammals and conferring spiciness to hot peppers. Catalyzes the biosynthesis of capsaicin, a pungent component, and of capsiate, a non-pungent component, from vanillylamine and vanillyl alcohol, respectively. Can transfer an acyl from (6E)-8-methylnon-6-enoyl-CoA to vanillylamine forming capsaicin and CoA.
Miscellaneous:
MISCELLANEOUS: Plants silencing PUN1 exhibit low levels of caspaicinoids in mature fruits compared to wild type plants.
Sequence:
MAFALPSSLVSVCNKSFIKPSSLTPSTLRFHKLSFIDQSLSNMYIPCAFFYPKVQQRLEDSKNSDELSHIAHLLQTSLSQTLVSYYPYAGKLKDNATVDCNDMGAEFLSVRIKCSMSEILDHPHASLAESIVLPKDLPWANNCEGGNLLVVQVSKFDCGGIAISVCFSHKIGDGCSLLNFLNDWSSVTRDRTTTTLVPSPRFVGDSVFSTQKYGSLITPQILSDLNQCVQKRLIFPTDKLDALRAKVAEESGVKNPTRAEVVSALLFKCATKASSSMLPSKLVHFLNIRTMIKPRLPRNAIGNLSSIFSIEATNMQDMELPTLVRNLRKEVEVAYKKDQVEQNELILEVVESMREGKLPFENMDGYKNVYTCSNLCKYPYYTVDFGWGRPERVCLGNGPSKNAFFLKDYKAGQGVEARVMLHKQQMSEFERNEELLEFIA
The following text describes a protein:
Function:
May transport cytoplasmic succinate, derived from fatty acid oxidation, into the mitochondrial matrix in exchange of fumarate during lipid mobilization in seed germination. Conversion of seed-reserved triacylglycerols into sucrose is necessary for growth before the onset of photosynthesis and involves fatty acid beta-oxidation, the glyoxylate cycle and gluconeogenesis.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MATRTESKKQIPPYMKAVSGSLGGVVEACCLQPIDVIKTRLQLDRVGAYKGIAHCGSKVVRTEGVRALWKGLTPFATHLTLKYTLRMGSNAMFQTAFKDSETGKVSNRGRFLSGFGAGVLEALAIVTPFEVVKIRLQQQKGLSPELFKYKGPIHCARTIVREESILGLWSGAAPTVMRNGTNQAVMFTAKNAFDILLWNKHEGDGKILQPWQSMISGFLAGTAGPFCTGPFDVVKTRLMAQSRDSEGGIRYKGMVHAIRTIYAEEGLVALWRGLLPRLMRIPPGQAIMWAVADQVTGLYEMRYLRNAPL
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Domain:
Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence:
MDPNCSCATGVSCTCADSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCVCKGASEKCNCCA
The following text describes a protein:
Function:
Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MPQDMPPSGGYAPVQYKRNLPARGFRPIYYLVGMHLFMAYGYYKLFYGIREQHELAREKVWSRLHLVPLLQAEEDRDQVRRHFADKAREKELLGTESKVYNSDRYVEPMGLKVVRYSWLTLFLLRLL
The following text describes a protein:
Function:
Probable mannan synthase which consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosic polysaccharides of plant cell wall.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MGQRKTDAGLQQEEGTPKKRAHLVNFRKVQSIGLQVGFFVLLCWALSRLVYGGTLDAGTASRGWKEFRTRWVLPLMQPVLNFLVGAFLLQSVDKVLLVAAGVYLGLRRSGKAGAPSVAAATTQDEGTVVGMPAYEPAVVVQIPMCNERECYRQSITAACRLDWPQDKLVIQVLDDSDQDDVQALIHEEVDAWRATGAPIFYLHRAVRAGHKAGNLAHGMQDPSAKHCEFVAILDADFVPASDFLRRTVPHFEGQPKLALVQARWAFVNPRQNLLTRFQNIHFAYHFEVEQQVQGHFNKFFGFNGTAGVWRVQALQDAGSWNDRTTVEDMDLAVRAHMLGWEFTFLNDVRVPSELPASYVAFCKQQHRWYAGPMRLCLLTAGSTLASRTLTAWHKFNLLACFFGLRRLVLPLAAYPLFCLLLPATVLVPEATVPAAVVYAMPLLLAFLHWLPHPGSWPLLLPFLVFENVLYRIKFQAIVSGVLGFKGASDWVVTAKTGAVQEADEFDDDLDGGLEDVPEGIEVEDGALGEARDGDSVSPCSAKSVDAFVVHAGSESSDQLAAYDLPPLAAGLTVRTGREPSVMGGKKGAFRSASLPPQMKRQLSGAAERALLSPSASRRRPGGTPRKGDAASLLTPRGREVALKRLERTLSRLPSMQQVRQRVTWASCKRFWAARKVQGPEMGMAAYMLGAAAYGVAVGDTRYTLFLVVQGTGFLVAGLDLLGC
The following text describes a protein:
Function:
Required for gliding motility and chitin utilization.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MRIKNSGILLLAAILLFSCDKKRVFDEYKSVGSAWHKDSVVTFDLPVLDSTKKYNLFVNLRDNNNYPFNNLFLIVAIETPSGFTKVDTLEYQMANPDGTLMGNGFTDIKESKLYYKEDVKFKGKYKVHIKQAVRESGKIPGVEALEGITDVGFRIEQKD
The following text describes a protein:
Function:
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.
Sequence:
MSVDQGSLAKVVKGLHRKLKKDLKENGDFATVWDKHCSDRKALEKYTEAMHSLATLEWTKNSPGGRADWCYQVCMEYFKGGGLKMAIEKQQRRVGNKMASAQNLKYTFLFCSWPSVDKKFPLLDVGSCYNPFSEFGEFHSVALDLQPATEKVYKCDFLKLEIVENQCLASNLITSKLNLPSESSITHLPASSFQVVVFSLLLSYFPTPIQRWDCCLKAHQLLSVNGILIIITPDSSHQNRNAAMMKSWKLGIESLGFIRWKYVKQTHVHCMVFRKVSPCHTKDKTTKVLHAPEMLYTRQDYTGNDSDDSDSDGVKNNETRPEETDKELAKLFDELPAFD
The following text describes a protein:
Function:
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Nucleus.
Sequence:
MGSVCKDEREEVIQAWYMDDSNEDQRLPHHKDPKEFVSLDKLAELGVLSWRLDADNYETDEELKKIRESRGYSYMDFCEVCPEKLPNYEEKIKSFFEEHLHTDEEIRYIVAGSGYFDVRDRNEAWIRVWLKKGGMIVLPAGIYHRFTLDSDNYIKAMRLFVGEPVWTPYNRPHDHLPARNILKHLWTRRMLLLLESLLEYVEAFGSIIMITIMSSLVLYCCILRMYVVFVLKYQKTYKNTCA
The following text describes a protein:
Function:
Specifically methylates guanosine-37 in various tRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MRIDIITVLPEMIEGFFNCSIMKRAQNKGLAEIHIHNLRDYTEDKYRRVDDYPFGGFAGMVMKIEPIERCINALKAERDYDEVIFTTPDGEQFNQPMANSLSLAQNLIILCGHFKGIDYRIREHLITKEISIGDYVLTGGELAAAVMADAIVRIIPGVISDEQSALSDSFQDNLLAAPVYTRPADYKGWKVPDILLSGHEAKIKEWELQQSLERTKKLRPDLLED
The following text describes a protein:
Function:
Proton-associated sucrose transporter. May be able to transport also glucose and fructose.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLLVVMRMAPQNADSESMQVQELPVPLPDLQKPGSADTHDETISEGSIDRIPVRLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPVLGLLFTPIIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLNGSAIGLSLGDVPNRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLGAWFRTQNQVLFFFAAIIFVVSVTLHLFSIEEEQYSPQQERGGEAADALAPAARVHILDGGVALFPEEVQSEHELTLDYLSVDMVRSKSDSVLHVPDAALDLEPELPFLPDIEPSIFHDGSYPGTPRSTSQELARARPARLASLLRETAKEDETLLDNHLNEAKVPNGSGSPPKDGLVGYTRVDTKPSAASGSMRRRRHMFRRQASSTFSYYGKIGSHRYRYRRANAVVLIKPSRSMSDLYDLQKRQRQRCRHRNQSGATTSSGDTESEEGEGETTVRLLWLSMLKMPKELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGDPKAPSNSTAWQAYNAGVKMGCWGLVIYAATGAICSALLQKYLDNYDLSIRVIYVLGTLGFSIGTAVMAMFANVYVAMIMISTMGIVSMSISYCPYALLGQYHDIKEYVHHSPGSSKRGFGIDCAILSCQVYISQILVASALGGVVDAVGTVRVIPMVASVGSFLGFLTATFLVIYPEVSEEAKEEQRGLSSQPTGDGDGGEKPTVLTLSRKEGLQGLVETESMV
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane.
Sequence:
MTVTYNLSVSTASHLTAFYKVMFRWKGSLWKLVAAEMFVWYLSVLCTLAIDACFIAKSPFGRDYHEFISWLSKFAIFGCLDWPNSAAHMLNTFMRRQKLSAKRESKLRNTFARHLRLAYILIFRDISMTTRTRAPTLEGLVKAKMITQKELEMLHAGRISEEACKYWIPLQWIIVRIREMRATSKKDSLMSDYESVEFFQEIANLRGNLGDLLSFDWVPMPIAFMQIITAAVYITMLLTVFTVQDKLVDNDGVVDFLTASWTVVALSAQLLLYLGWMKSVHVIINPFGEDDDDFEMEWLLDHHTSVLNTLLSKRDSGKQFAPSKGLDVQPNLKLSHTVGSLLRATDRGIKGSMADVNPREDPSEYVATTIRPGASTCIVSIITRCQGPCYDEGLQREHEAVESIRTREGNQHIVPFIYSYFRPQYPYQPRKIKFSPSNEDPRGTILAASAYSHFCDPLPPFFANLLSSLFNCTRRSHPVTHHPKVPSSHIHTIVRFASFHPTDFIIVSCALGAALAYGALLRVSELISLRWSDLSWSEGLLRASIRKTKNDQFSEDLYSLCSRVGISKFTPHQLEEEVRWSRLEEEPPSIKYKEGGDGDRYIYIYRELLLKIESSRLFQKTVAGLAPYLSDTVETQGRSLPLP
The following text describes a protein:
Function:
Involved in selective mitochondria autophagy (mitophagy).
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MQTMGGEHLLLSQLKGSFFLLLLAYFFRGRSPYYARCYRRLAVTPGAITIAIAIATDSIPALAKSKVLVSVCSHTDPCTASCNLIPFPRPFSNSLTRFLFCLGSARFCISFPCFGLSI
The following text describes a protein:
Function:
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Subcellular Localization:
Nucleus.
Sequence:
MAKARKPKNEEAPGAKTSENTGAKVLHQKLFLSIDFKKRQIYGYTELEVSVPDIGIVGLHAENLGIESVLVDGEPTVFEYYPHHQNSETESNWNSVSDPASAADAAAMEYVGVLKREDTANLLINCCKPSKDLSEQLDSVTLENGSQSSGEAKQNVKLIRINYWVEKIESGIHFDGNIVHTDNQMRRARCWFPCIDDEYHRCSFDLEFTVPHNFVAVSVGKLLYQVMCKEDTTQKTYVYELAIPIAPRWVSLVAGPLEILPDQTNFLISNLCLPHDLSRLRNTMEFFHEAYSYYEDYLSANFPFGFYKQVFLPPEMVVTSSTSGASLSIFSSHILYDERVIDQTIDTRIKLASALAKQWFGVYITPESPNDDWLLDGLAGFLTDMFIKQFLGNNEARYRRYKANCAVCKADDSGAMCLSSSPSCRDLFGTHSIGMHGKIRSWKSGAVLQMLEKQMGSDSFRKILQKIISRAKDPSNSIRSLSTKEFRQFANKIGNLERPFLKEFFQRWVASYGCPVLRIGLSYNKRKNNVEMAALRECTAALDARLSVIGATSDSESRDVDAGWPGIMSIRVYELDGMSDHPKLPMAGDRWQLLELPCHSKLAAKRYQKPKKGGKPDGAEDNVDAIAPLENKTSIESPLAWIKADPEMEYIAEIHLHQPLQMWVNQLEKDGDVVAQAQAIASLEALKQHSFSIVNALKNVLTDSKVFWRIRIAAAFALAKTASEESDWAGLQHLIKFYKSRRFDAEIGLPKPNDFRDFPEYFVLEAIPHAIAIVRGAEGKSPREAVEFILQLLKYNDNSGNSYSDVFWLAVLVQSVGDLEFCQQSLTFLAPLLKRIDRLLQFDRLMPSYNGILTISCIRTLAQTALKLSDSISFDHICKLIEPFRNSDTILQIRIEGSRALLDIEYQSKGISSALLLFMKYLVEESSLRGQVKLCVHTMRLCQIAVGCDSDDCVDTVTLLDLLHLFKSHVVFNNELLRYYLFCIFQILAGRPPTLFGVPKEKPLQLVDVEACIEPKNVFLVPGAEAGEPSLSALGDAKGQSLDVAPYGVPIIPQEMFMPIVPELMLPEPVAAYDETQHLEPRMESQNQPSHENPIVHEIPSDVEGPTEELAHREANPPTKEPQKEPDVVSVSVSHEVKKSVIRIKVRPSGATSRAEGSARTIERSQGIVVRHDIDRGQTSSASVDAPQRISTDAVSISNQNHVEEVNSCHDVGSRMTASIGSVKFASEGDIFGKELQCTAESGKPSTSQKADNNNRTVPPSFLPLDHSMENEAQQKYASLQTLSIGKEKEKKKDKEKKEKKRKREDPVYLEKKRLKKEKKRKEKEMAKLVSSTTDPAKKKIESVAEVKEEEPSDGAMLIKVEPKTEPSTAEARPLPKFRIKLKSKAFNNS
The following text describes a protein:
Function:
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.
Sequence:
MRGAAARRSRSTSKHPLDTDSLDTDPLETSGWCEGPEIEGEQTTELKSHSKEVFQELYEKGDLIGYGGYGCVYAGNRKTDGIPVAVKCVYRKTIKKWANLQQGTVPLEIVLHQQVCAPPACASVVMLLDWFRMPDRFLLVLERPEPCQDLFNFLQDVGGFLEEPLARDFLRQAVEALLHCLSRGVVHRDLKPENLLVEARTQRLKLIDFGSASPLQDGLYSDLAGTLHYFPPETILRGEYQAIPATVWSVGILLFHMVWGDVPFSDDNEIVKGTLHFPRDISRECRNLIRRCLTSCPSNRPTMEDILLHPWMKQIGK
The following text describes a protein:
Function:
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MKSNRLSDHLILIAGALFMLVPLWLIFASSTHQPNTIVSEGLQWTLGDNLSAVYREAWNKSLGFAGNVTAQTMIVNSMIMGLGFAIGKIVISMMAAYALVYFRLPYASAWFWLIFITLLLPLEVRIIPSYEVVSNLGMLNSYTGLVLPLIASATATFFFRQFFKTIPDELLEAAQLDNAGPIRFFIDILFPLSKTMMAAIFIIMFVVGWNQYLWPIMMTTDEQYNTIVMGIKQILNNINETSLPRYDYAFAMVILAMLPPVLVVVIFQRWFVKGLVESEK
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity); This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MINAQAFGTALFQLSEEQKQVKKIYEECHFFLKLMRNFKDGSLSFLLNSYTLTKPDKIRLVDKLFKNHFCQVFVDFLKVIILKGYFTLVEQAIKYFFDNVESQKHIQFIKIITAFELSSKQLNKIIAIMEKRFKTKVVYKTEIDRSLISGIRIESSSHLFEKNVRDELKRIMAHFI
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNVGDLKSANDLYESVRSIEGVTGVHLFRIRDAGILKSTMIPELDALTTISLDELNKSPTVFTKNLLQGCGGTDLDVPAELKRLVIFVCNILESCNEFTDLGSARLLRLTFDSCQLVIMYDSLFVVAITKDET
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Miscellaneous:
MISCELLANEOUS: During the reaction, ATP is used to activate the C2 atom of U34 by adenylation. After this, the persulfide sulfur on the catalytic cysteine is transferred to the C2 atom of the wobble base (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards the activated C2 atom on U34. Subsequently, a transient disulfide bond is formed between the two active site cysteine residues (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MPRVVIGMSGGVDSAVSAFLLKKRGFDVIGLHMINWDVQEEGTSHCPRSKDESDARNVCDRLNIPFHTVNFVKEYWNDVFLKFLENYKNGRTTVPDIDCNQSIKFDVFHKIAREKFNADFIATGHYATTNFGDFQQNAKDSDEIRLFSGKDPLKDQTFFLCTVNQEQLKRAMFPLGSLQKSEVKRIAEEQGFQEVAKKPESMGICFIGKKKRFSDFLDEYIEPKPGRILLKNGSEIGNHHGIHQFTIGKRINGKYLEARSHLGFFVSHIHSDTGDIIACEGSHHPDLYASRFLINHPKWIRTFDPFNRISSNNFLCRIQRTHPPIPCVAEKQEQFLSVIPRLALRATAPGQMCVFYNTKNECLGGGEIMNIQETL
The following text describes a protein:
Function:
RNA helicase.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MAGDRMVSHAISLDYQTTPTSGKKPHKRKRDLDGSTVASATPTKKSKKDRTVPSTPASPKESKKRERISGSASVERAPKESTKKKGAVSPIGEPTKSPDVRADIKLKKKRKTPKDNSESDEKSTDLAEQTVPPDVSGVATNKDSVETKKPKRPKAAEHAERDDESKRTKNKFAGILSKFERSAKVKKATEKLHREDETPVQDENVAQPVIAQGLEPIPQPKPVVEEAEKPTYSSLPPWLANPVRASAETRAKFSDLGIEPKLLRVLEVNGYKEAFAVQAAVIPLLLKGPNNHTGDICVSAATGSGKTLSYVLPLVTELEQIPAPRLRGLIVVPTRELVKQAREACEFCTAGTGLRVGSAVGNVAIKDEQRSLMRIEHVYSPESVESRRKAELTGEEWADFSLQDYISNTTDLGETLPGYIHRGEPNVDILICTPGRLVDHIRYTKGFTLKHLQWLVIDEADRLLNESFQEWVDVVMQSLDARKAYGAFGPSGRFLADLGMSLQTKEPRKVVLSATMTKDVSKLNSLRLTNPRLVVVGGSDQTTTADDESGVVVHADERFTLPTTLREYSIAVGDGEHKPLYLLRLLLSEMKLDVPSSTKRTASVTSESDDTSSEGTSSDESTSDDSSSDESSSEDSDLDSESDASSDTSSSEESDDSDNSSESASDDEETAEAPSNHTPQRTTVLIFTKSSESASRLSRLLALLNPSISGLIGTIVKSNKSSASRKTLSAYRQGKISIIIATDRASRGLDLQSLTHVINYDVPASITTYVHRVGRTARAGNEGSAWTLVAHREGRWFTNEISKGSNGKITRAGKIERVPMKLDNAKELKSKYTSALAVLEQEVRSVGTKKAAR
The following text describes a protein:
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.
Sequence:
MFPPSLCSCSLRAVSSSHTPALGLIISTQLRVVARNKAVATSQNTLMSIAVEESSVSTDAAVQRTNDDSVVSKRSAVHKGYFDDPYLRFFVKKLSRRSPLINRGYYLRMLVITDVIERCIHHLRCLKIRCTVNTPPLPPTGNAVALPVQVISLGAGYDTLAMRLKQRPDYGNVHFYEVDFPAVMQSKSMLVKMAPFGSFPEDIVADPGGELVKLYGNNYWAVGTDLRSTNRDLVTCLREVSPQFSTDNPTVLYAECVMQYMPPVAASHLIKQIASAFPCAIFVAYDQLHPSDSFGTVMLSALRTKNSPLLSIGECPSGAAMVRRAIQQGMCKARFANFHDLSKFYISGDNHDRVEALEPFDEWEEWCEMCEHYGITMATTLSDEEMPDHSCFKEIMEQKEEELCAGLPCKSQGNEQNALRLENWPTGRFGFEGWGNGGAVAERLFSGDVLIISFGGFSVTRGHQRTNTLHVHSLRSGDRKVLQSSLSVEPPSLVFHSMSRVSRGSYVVFGGRTNPQDVASDAYLLRLELPTDGYGEEANIVATWSKLQQTADDGKLPVARYRHAATSVTNSGCDENTDMRNIFVFGGRCATGEFLNDAWLGSVGDGIIHWKLLRLSGDIPPPCCSSGVVDATMGSIVLLSGGLLRGGVSDSSLWSIDWVTGVCNKRDAIVGPRFSHTMCRVSVNGVTGVLVVGGSSTEPSASFQATQILLLDPVSGEITEALKLPPMCPTWTRHSCVALEDGAVGVLGSGFTCFSFGTFATKPLLLLLGGKRGGRNAHSWDVSKLESTSTSAAANAFSICCTVQRRPVEEQSLSVGSFSVLVNHPFKPVVFRDVDMGCCVKAWSDPAYLNRVEGNTRVSVHVARNTELLDFVTKNFSFQHVSFNELLDHCLASSAALAESGNLPGKLNEERETWYLRAVASNMKSERANIWRDFQGLKDDFVLPSATVDHIKPRMHQACLRISAPPLQLWTHYDTLDNVLCQIVGRKRVVLFPPSEYNNLYISGSSSAVTNIDKPDYMRFPRFIDASRHALEVEIGPGDMLFIPALWFHHITTLEGSYSMSVNVFFERLPHADYDKKDLYGNKDIPAASRLRAGIVKKVKEMISETAVERTSDGKALTPDLVEFALRQALQDLMEVADDMCTALR
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MEHRKKITTIFITTLLLTVLGFSISVHSRELAGSSSPSPENLGLIAGTRRPGSLPASCDSKCKQCEPCMPVEVSVRAAELEENEYYPQVWQCMCQENIYPP
The following text describes a protein:
Function:
Member of a two-component regulatory system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSAGFGSRMSLGVRLSLLFAACTAAVSLIAGLIFSRAIDEHFVELDHMAMSAKLAVFRDELRGLGSEQQMRRREAELLRELARHPDLGLRLNGPDGNLWFERLPQPAHPGLPANRELGAPLEPGNDASPRLTVILDISHHQHFLQRMRQLIWLTMSLSALATALLGAWATGASLAPLRRMREVAARVSANSLTTRLDASRMPEELRGLAGELNAMLARLEEAFQRLSAFSADIAHELRTPLTSLLTQTQVVLSRPRSLEDYREALHGNLEELERLTAMVNDMLLLAKADHGLLAPSRQALDLGAEVDSLLEFYQPLAEDRDIRLLREGSLSLPGDRGMLRRVLANLLDNALRFTADGGEIRIRLGDRRLSVENQGPAIPPERLPRLFDRFYRADPARREGQGEHAGLGLAICRSIVQAHGGEIRCESADGWTRFVIDFARPRR
The following text describes a protein:
Function:
May play a role in chromosome segregation.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus. Chromosome, centromere. Midbody. Cytoplasm, cytoskeleton, spindle. Note=Exhibits cell-cycle-dependent distribution during mitosis.
Sequence:
MSQVTLLDEVSQWNQETCQQELKTVLPKLVAMHHDTDSWEEHTNILQIITSRFLPHLSLSDLETGCFSTALPKVVKVFASLLEEISKQIGGLSSQNTELQLFLRKILKTMVQTLECLSGCVRHVCSIEESVSFSNIRSLPSCILGVLKDTFQHCKDSEVMYSGRLSLVGDLLQGLFKEAYSLQKGLMELLDKINFEDTASEEEISDIVTVIHSLLDICLIISRLDIALHANTWKFIIKQSIKYQSLVEDRLHHTDISFALCEDLCRSVENCLELAQQIQQAGLQEAVHSPEYKLFQKATKMCRFFANTLVHYTKEFKVFLSKSCSRFHQLYLQINSKFLPSLCAPSVPPTLSEELRVAVLVPMDAMLTQMMSFQPFAESVLNPDHQSSAKLFLPQCLLLVNVMGKLSSQPEEALRLWSDGSQFPEETPRWSVFEAVFQSFRLCVLERLVPVCLPGVMLRGQAQGTVSLHQHVCVHMCACVAVLPAQHFPPLERSLLAAVLQADTQTALLATDVWCFLARYGTAELCYHHVVLIAHLLRACPAGGYQLFHLALVLRRLLFLMTPKHQVEFVERFPLSQEENLCVWRHTLLKCLCVEARVRVEEQVLDRATVVLEEWQNSGCRLGEIPRLNRILDCVLLVVGGSGTQNECVESLVKIISQLWSHMRSSQVQVHVTLQCTVKLLLSLSAVLIKSLEPHIILQAVSCLSGLSIHQCPDDLLLAALEFLASLGQIFIPPNIQGQVLPQISSLFNGFLTRPSWLILHHVLEAFGCFAEITNHEEVISQTLKTEEVKSKVLNFLSKTVSRQESEETRLERLKEWKCVIEKHCQQMESEKSQPAQTPLTEEPCAKRARQETKAEEEYERYLQTAEGALKALQAIERSEHSPSPPQWVRARLQLLQTLITQINTTTEEQS
The following text describes a protein:
Function:
Involved in respiratory growth and required for cell survival in the absence of prohibitins or GEM1.
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MVLSNVKIFRLKSHRAFRIGPMIKAVAGNLLVKRFYQPKLERIPPASLLLKQKIRLAQNGSTTSTENPISFSQTMSEIFSVLQPSAPDLDEDETSGLKRDHLLTERLNNGELGVIMNKFFNPSSTHNNQLIDTNILLQNFPKLSGNDLDLLDFAINEKMRGNWNDLKQDFIQLWYYKSFGFLGPRTQFVLTNSSPSVRSQFLKLPFIEYNWFLLQNNKNANILPADVQNVVKVFHLDDKRFTWKSIDPFSKAIISFVVFVSIYVWLDESAKQKTKELPAQKSTVISE
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.
Subcellular Localization:
Nucleus.
Sequence:
MSGAGAEVVRLFEKASTAANAAGAGDSLVASEESRAADALQQLQKVSISTAVLVETQVAKKVRRLIKHPSRKISAAAQALLDTWKKAVVAEGPAKSAATPQVPNDAPDRAQPNTNEGNSVGKPMGSATDAGALPEGELAEPPSPSGAAAETPMSRAVSREEVEAALAGVEVIGVELRDKLRGNIVEALMMAQVDARTCACNAVAVGTAVEAELYKQFVKDARDMSLYKAKYRSIHFNLKDKNNPDLRNRVLTGGVSPARLMTMTAEEMASDEKKYQIKLIRDKAMFEADRSMKNVASTDQFKCGRCKQRKCTYFQMQTRSADEPMTTFVTCTVCQKRWKFC
The following text describes a protein:
Function:
Required for M.tuberculosis resistance to oxidative stress in addition to its role in resistance to acid, which is essential for virulence. It protects M.tuberculosis against phagolysosomal concentrations of acid and maintains its intrabacterial pH when phagocytosed by IFN-gamma-activated macrophages.
Miscellaneous:
MISCELLANEOUS: Disulfide bond increases the proteolytic activity by stabilizing the protease in the conformation in which the active site residues are properly positioned for substrate binding and catalysis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTPSQWLDIAVLAVAFIAAISGWRAGALGSMLSFGGVLLGATAGVLLAPHIVSQISAPRAKLFAALFLILALVVVGEVAGVVLGRAVRGAIRNRPIRLIDSVIGVGVQLVVVLTAAWLLAMPLTQSKEQPELAAAVKGSRVLARVNEAAPTWLKTVPKRLSALLNTSGLPAVLEPFSRTPVIPVASPDPALVNNPVVAATEPSVVKIRSLAPRCQKVLEGTGFVISPDRVMTNAHVVAGSNNVTVYAGDKPFEATVVSYDPSVDVAILAVPHLPPPPLVFAAEPAKTGADVVVLGYPGGGNFTATPARIREAIRLSGPDIYGDPEPVTRDVYTIRADVEQGDSGGPLIDLNGQVLGVVFGAAIDDAETGFVLTAGEVAGQLAKIGATQPVGTGACVS
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
MGGKRKSTADVKTPPTVGRRPGRPRKNTPPEAIRRPGRPRKSEPGVEVPLARSPVPAQTLPSPRSEREEEANGGLLELARGAAAIAAAEEEEEQVRMRCDLCHGPLRPPIYQCTSVQHVACRDCGADECRPCGGDPAAVFVHNAQLDALFGYIRVPCPFRKFGCASSVAYRDLAAHETACTWAPCACAECGYKGPPSGLLRHLTELSGRHAWTAHRITYGMDHRFAVPVPESSEQQCEDHGLLIAEDGAVFLVAVGGAGGVRRVTVVCVRGNVGTGPVYSSSVEVAGPDEARRLKLEKKVAASCSAPVEFDVLAQPECDTVPVYPEMLHGEELHLCIRIGKTKIICS