lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MTPRRRPANRKGPRSLEHRKLHSPHLLSPCGSRASTFSLDMAKAAYEATPPAETSQESQDASEHEEATAAAAAAIEAVVAELETAGDASAASASSDGETTAMLQHMQQLQRQREVKEGQEQALRRSQRKRRTVDMLSPSEETATRHKRRAVDAKRIKVEKLLRTRPAAAATDAARAAAAAKEKKLKQATGTTKRKIAGAKVGKAGKGPKGVLSPVQDEQKKTPQKKRNRKARRSLDAQYSYESETQYVAKLIAELYEEQEQDDRGMYSITKETVLTETSSCARSQEVDELSLEEFRRLMTYGEVSVESIAATILPLLNLDEDDVFFDLGCGTGKILVQAALQTPCKRTIGIELMQNRVLEGHKALKRLKALDLSILHEKQIEVFRGDIFVPPEEAHLMDATVVFINNVMFGPVLMLKVLALLKDMPKLRCVVTLRKICERHGNVKCTRAGNYCIAYVHPPIEAEIDVSWADKTSVYLYESLEYKLCELTRELAHGAHQVVSWESEDDLSP
The following text describes a protein:
Function:
Involved in the catabolism of quinolinic acid (QA).
Sequence:
MEIRTFLERALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLEMTGIECVQTIKDKERFKPKDALMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRLLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLRHVKDLKSFLTHARKNLPFTAKIEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAAYRDAHYPFVLLEASGNISLESINAYAKSGVDAISVGALIHQATFIDMHMKMA
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Mediates the proteasomal-dependent degradation of ATG6, a component of the autophagosome complex. Requires TRAF1A/MUSE14 and TRAF1B/MUSE13 to target ATG6 for ubiquitination and subsequent regulation of autophagosome assembly. Modulates directly the ubiquitination and proteasomal-dependent degradation of FREE1, a component of the ESCRT-I complex. Modulates directly the ubiquitination and proteasomal-dependent degradation of ELC/VPS23A, a component of the ESCRT-I complex.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome. Endosome, multivesicular body.
Sequence:
MASGNPFFDDMRSKPEVIDPPQSEDMMDAGENVNDPASNALKPNVIVSSSVRELLECPVCLNAMYPPIHQCSNGHTLCSGCKPRVHNRCPTCRHELGNIRCLALEKVAASLELPCKYQSFGCMGIYPYYSKLKHESQCTYRPYNCPYAGSECTVIGDISSLVAHLKDDHKVDMHSGSTFNHRYVKSNPQEVENATWMLTVFSCYGQYFCLHFEAFQLGMAPVYIAFLRFMGDDNEAKNYSYSLEVGGNGRKMIWQGVPRSIRDSHRKVRDSFDGLIIQRNMALFFSGVDRKELKLRVTGRIWKEQ
The following text describes a protein:
Function:
DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis.
Subcellular Localization:
Nucleus.
Sequence:
MAANDYPQQASQGYGAYPSQAGQGGYGQQQGSQQGYTGYSQSAGGSSYGQSGYSASYGQDQSSGYSSQSTPQGYGSSAYGNSQSSTSPYSSGQPQQQSQSSYSSYSQQPPASSNTGSYSGSSQSSTYQQQQSGGYGQQPSGGYGSQQSSYGGQQQSSYGSQQGQGSYGSQQQPSSYGQQQSSYNQPQSYGQQQTPYSGGGAGGYNQDSPSAGSGSYGGGSDQGGYGGQDSRGRGRGGFGGRGGAGGGGFDSRGRGSRGGRGGMGGGERGGFSKFGGPHEGGGPPRHEMDEQDNSDNNTIFVQGLGENVTVESVADYFKQIGIIKINKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNSRGGGNGRGRGRGGPMGRGGFGGPPGGSSSRGGSGGYPSGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPEGPGGPGGSHMGGGFGDERRGGRGGFDRGGFRGRGGDRGGFRGGRGGDRGGYGPGKMDSRGDHRQDRRDRPY
The following text describes a protein:
Function:
Transcription factor that acts as a positive regulator of nonrepressible acid phosphatase activity. Is a major regulator of responses to nitrogen and carbon starvation and is essential for the expression of genes involved in vegetative incompatibility (like pin-c, het-6, and tol). Vegetative incompatibility is a non-self-recognition system ubiquitous in filamentous fungi which results in programmed cell death (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MEGFDTMALPYLASPLSLGNMQGTDYLNALQGMDLPDQRSNFDSETFVSGDDLTFAHLSPQTLKRFSSGYEDSFPEMVTSFDPPPPAEPPADSSIDHNNKLLSFSMPVYPWTLLDYSFRRASISISAQLHGMFFLAESPWTTSPTENAPPQQGAELTCYRRNLFQITGSVTLPRALRYIITDTGDRIPIVAHELTVSATESVEGNSVKIISVPWKTPAANDAGKDTGNSSNTAAKVEKEPPAIPLDMLTGQDLDADYATFPIAWKRLQFRVATANNGRRKELQQHFVVRLRVVATLSTGMKTPICEVHSGPVIVRGRSPRNFQSRKDLPLSGSAAASRKNAQAAAASNNLTRTSPSLTDKAKTVVKSSSPETSSNGVPQQSPPNWALATNSTLPPPTTTTLPHSSVYSQSSPEFSRPVEAHRRTTSAIAAPINLSLLDDDSLNLSNGDSRPHTSFSNDLASKSLSVDSGRPVKMRKVSHSMPQAQSRSTSATFLNTANFQQMLPVPFTSESADVLYEYFPLGLEDWQGPVDAVYRPHVVHHTNMPQMKYITARGQSKRYFAAEDVF
The following text describes a protein:
Function:
Chromatin-associated factor that regulates transcription. Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription. Regulates the epigenetic status of rDNA.
Subcellular Localization:
Chromosome. Nucleus, nucleolus.
Sequence:
MNRSRQVTCVAWVRCGVAKETPDKVELSKEEVKRLIAEAKEKLQEEGGSDEEETGDPSEDGMQSARTQARPREPLEDGDPEDDRTLDDDELAEYDLDKYDEEGDPDTETLGESLLGLTVYGSNDQDPYVTLKDTEQYEREDFLIKPSDNLIVCGRAEQDQCNLEVHVYNQEEDSFYVHHDILLSAYPLSVEWLNFDPSPDDSTGNYIAVGNMTPVIEVWDLDIVDSLEPVFTLGSKLSKKKKKKGKKSSSAEGHTDAVLDLSWNKLIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPFEAQTLISGSYDKSVALYDCRSPDESHRMWRFSGQIERVTWNHFSPCHFLASTDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQIKGCLVTASADKYVKIWDILGDRPSLVHSRDMKMGVLFCSSCCPDLPFIYAFGGQKEGLRVWDISTVSSVNEAFGRRERLVLGNTRSSSISGPFGSRSSDTPMES
The following text describes a protein:
Function:
Plays a role in determining ER morphology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.
Sequence:
MGNLFSKKNGFEKQLLDMETKILNLEDKLSNSRIFHQKVLHKIVLYSFAIEFFIILFTYVKSRSLESIPEKLFCCIYLVLFPIFILILTKVYGFVYKYLIKKNEVRLDSLKTGLQKKLDERKRETDYENTQKLLDRYEKNPPSPTNKPLGPPNLNNNNNNNNNNNNNNNNNNNNNNNNTLGNSMRNRNQPFNISSQQNQQQQRMIQPQQLSPQQLQLLQQQQRLSQQIVPSQQQQSQSQPQQQQPILNQPYNINNNNNNNKPPPPIQLPPQQSSQYIGNQQRLPPQQYQNEQKSKWWLDKLVDYLISDGPTHGSPLICSNCHSHNGYVPVEELSNIQFRCRVCKTFNQRDSVNNSTTNDDRNNSQNTGSNQQQSQSLQDQQPSIEEIDKNFSVTEQKNETNNENYSDSEKQLEENNNNNNIDNDSGSSSSQNTPNKKKGKGKGKGTPTKKTN
The following text describes a protein:
Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.
Sequence:
MGVSNKATSSCGSSTEGLLWKSLRVDLLSEDMDFTQHDEMSPIHSRDPKTINSNLKITDHHFDRVWVWSHALFEVSRLVIMPCLQLLHIYMHWIKAVWASILNSVISPFFSSFGKCNVICSVLSLVWFSS
The following text describes a protein:
Function:
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
Sequence:
MKSLGRHLVAEFYECDREVLDNVQLIEQEMKQAAYESGATIVTSTFHRFLPYGVSGVVVISESHLTIHTWPEYGYAAIDLFTCGEDVDPWKAFEHLKKALKAKRVHVVEHERGRYDEIGIPEDSPHKAAV
The following text describes a protein:
Function:
Component of the intraflagellar transport complex A (IFT-A) involved in flagellar assembly (Probable).
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body. Note=Localizes to the cytoplasmic and membrane-bound portions of each of the eight axonemes, localizing particularly at the flagellar pores and at the distal flagellar tips. Localizes to the basal bodies.
Sequence:
MKVEPLWSLDVGTQPVYSLVRTPDGTKMYAATGKTVVTFGPGPEITRQTSTQHPLVTCLAISPDGHMVVSMGTDGAVMFNDSTGAALFKYSHQNEVQAAAFSPDGSLFVSAAIGDVGIYHCRDVKTKVMKQSFKGTPRAIAWAPGSDWFVISTQDGDLVIMTPEGMELNSCNLGAPAWALKVVQCSSFLVQPNTALDVDIANSSDDEFTIPQTVTPSASASGRSGSGKRHKVELDREEFITSHNMDNFRILVASWDMRYRVINPSVYADGACIAKMTDGGSDSRSRSSSRRRLDGLLVAVSEIPFIPLCMEIIGNYVFLSGVGGSVVVLNSSNGRVLSSLYQVWESDPFISKAPLIPTESQSKHLPQKRTIMGQVTTCTDVNQRLMELRKREAMANRNVKNVTNPLAFHGMHTIWCYSMIHVEPSSLILGLSNGVLLCLSLRYAMIHSQYGSLYAYRRGLMSVSVMNLSTGRESILEVGMHVENLSIYESTLAIKTSSRLLLYRLQDPALKKRNIESVMDYYSSSTNGLIETDRSRRQNMSSLSYSFETSIKKRFVCSQLIVSNNHFFLCNVSHISVHDFSGKQTDRWTFKQLKCTYVRSIGGIPSNEAVLVGFDTGKVCIFKIGNKFPIELLLHRSPIVSLDISPDRKYISVVDRSDVVSVYKFLDDSEIVLGATNMAVVEHENTPTSYSRIAALAHVSLDGNLPGITTGQDYSVPLYTFKGTTSAIWDLVLPGVLARSTQKSVDICIDSGVSYTFQLSYPGSFVLCQNGNRAFIFNVSYLGQSLVNLDYSSLIEMVEVPMMPMVIYRTHKVLRMLLDSNYEAGAVFPSQAANYELNEAIKAANLGVPMDCWRDLAIAALLSNELDLAREVLATIGDIRSLKAIAEITRQTSTKTYLLLSALALSMCDHFSEASLLFAASDDIQMATELLFFINRECIPYNSPNSSLISSIAKKLICRELHSSLTGTEEKILEVLKTQGDSTYSPLGTQTAPEAKETNTALLTDFSDKLLAKGRATVNKFLSAIESGSSKADGPGNDNKDTYNYFNDYRILLRRQISSFAKTESERANLVVRHSKFLETSLEWRAAAASYLDMDDPESAIDVLITSKQTGALLRLVRIFPPVARELNHKAPSFNDFESPEDADEYAPSSVQNQMLKRAYRKALVYFEKSNDYSNAIFIAQRLGDPLVLLRLLIQQGSWSQVEALGKAYPEMMPSIHEAKASMLLREGRFIEALERLRLSGNTSKEAIIIKQLIDASIAECKFNLTRALTGQLAKQIAKTRAFAALSVSSMEYYAAIKAIRARVLVYTGYQQVMEYMVNILRSRDLSDITMIRLHDNTQSAKVVTAGIFLTSYAAMANELTNADSVFSEELENNTGILSGEDTVKASSQRSKKDNPPSLRSTIGFITSSTTPQLGSLAHIDLGINNMNIPPGISELIIWVCLALASRRTYPEVEARALKRILASRIPGPMIGYFRRQMLLVKGTPAKDFSHGESSDAESRDACPRCAAPLKALPPSRPVGAQDMAILSSLPHCCPVFSDICKNCGSPIVRSALSLKILPLVLAEPDDETSIAVALERAAAVEMDIEALMGETNRLEIGTDDLQTDEGVVDVLRRASIAGDGRGAVLTSEQFEKISPANIFIVDDTWSNPSLLPRFVVGNVIKRFFIRTISDFQLHYCTGCGFFFDGIEYEEYVIVTGSCPICGATNIVL
The following text describes a protein:
Function:
Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.
Subcellular Localization:
Vacuole.
Sequence:
MSTITIPQDIEIGGSTYYQINIKLPLRSFTIKKRYSEFQQLVSDLSRSLGIDSRDFPYELPGKRINWLNKTSIVEERKVGLAEFLNNLIQDSTLQNEREVLSFLQLPSNFRFTKDMLQNNRADLDSVQNNWYDVYRKLKSDILNESSSSISEQIHIRDRISRVYQPRILDLVRAIGTDKEEALKKKQLVSQLQESIDNLLVQEVPRSKRVLGGAVKETPETLPLNNKELLQHQVQIHQNQDKELDQLRVLIARQKQIGELINAEVEEQNEMLDRFNEEVDYTSSKIKQARRRAKKIL
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Miscellaneous:
MISCELLANEOUS: Present with 18500 molecules/cell in log phase SD medium; MISCELLANEOUS: There are 2 genes for eS30 in yeast.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKVHGSLARAGKVKSQTPKVEKTEKPKKPKGRAYKRLLYTRRFVNVTLVNGKRRMNPGPSVQ
The following text describes a protein:
Function:
Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase.
Miscellaneous:
MISCELLANEOUS: Present with 1970 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MNVLVYNGPGTTPGSVKHAVESLRDFLEPYYAVSTVNVKVLQTEPWMSKTSAVVFPGGADLPYVQACQPIISRLKHFVSKQGGVFIGFCAGGYFGTSRVEFAQGDPTMEVSGSRDLRFFPGTSRGPAYNGFQYNSEAGARAVKLNLPDGSQFSTYFNGGAVFVDADKFDNVEILATYAEHPDVPSSDSGKGQSENPAAVVLCTVGRGKVLLTGPHPEFNVRFMRKSTDKHFLETVVENLKAQEIMRLKFMRTVLTKTGLNCNNDFNYVRAPNLTPLFMASAPNKRNYLQEMENNLAHHGMHANNVELCSELNAETDSFQFYRGYRASYDAASSSLLHKEPDEVPKTVIFPGVDEDIPPFQYTPNFDMKEYFKYLNVQNTIGSLLLYGEVVTSTSTILNNNKSLLSSIPESTLLHVGTIQVSGRGRGGNTWINPKGVCASTAVVTMPLQSPVTNRNISVVFVQYLSMLAYCKAILSYAPGFSDIPVRIKWPNDLYALSPTYYKRKNLKLVNTGFEHTKLPLGDIEPAYLKISGLLVNTHFINNKYCLLLGCGINLTSDGPTTSLQTWIDILNEERQQLHLDLLPAIKAEKLQALYMNNLEVILKQFINYGAAEILPSYYELWLHSNQIVTLPDHGNTQAMITGITEDYGLLIAKELVSGSSTQFTGNVYNLQPDGNTFDIFKSLIAKKVQS
The following text describes a protein:
Function:
Part of a binding-protein-dependent transport system for arginine.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKPFEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTPERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYGFKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAIAFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK
The following text describes a protein:
Function:
E3 ubiquitin ligase that plays a role in the maintenance of muscle cell boundaries and muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix. Ubiquitinates the LIM domain protein unc-95, thereby regulating its dislocalization from muscle dense bodies and weakening the link between the muscle cells and the hypodermis. Regulation of unc-95 dissociation from muscle dense bodies by ubiquitination plays an important role in ecdysis during molting. Plays a role in the cessation of distal tip cell migration at the end of larval morphogenesis. Acts as a negative regulator of autophagy.
Subcellular Localization:
Cell junction. Cell junction, focal adhesion. Cell membrane. Note=Colocalizes with deb-1/vinculin in muscle dense bodies.
Sequence:
MASETKAPSEEPTSSSNKDESARFECNICLDAAKDAVVSLCGHLFCWPCLSQWLDTRPNNQVCPVCKSAIDGNKVVPIYGRGGDSSDPRKKVPPRPKGQRSEPPPQSFAGFNWGGDGGMMGGGGPNVHFSFGIGTVNGLFPLMFMLPFIQGIFPLSFVASFFGNGNQGAAAAGGGNGGGNDGNDGTHAHTHGHTHGPRGHGESAAPGSRMAQEEEYLSNIFKYIGFFMLFWLLFV
The following text describes a protein:
Function:
Acts as a transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (By similarity). Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex (By similarity). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development. Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Subcellular Localization:
Nucleus, nucleoplasm. Cytoplasm. Note=Enriched at replication foci throughout S phase.
Domain:
The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein; The SP-RING-type domain mediates interaction with SMAD3 and SMAD4.
Sequence:
MNSMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKSRQNDPPGKLPMQPPLSSMSSMKPTLSHSDGSFPYDSVPWQQNTNQPPGSLSVVTTVWGVTNTSQSQVLGNPMANANNPMNPGGNPMASGMSTSNPGINSPQFAGQQQQFSTKAGPAQPYIQPNMYGRPGYPGSGGFGASYPGGPSAPAGMGIPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGPVCSSFQMGPTQAYNSQFMNQPGPRGPASMGGSLNPAGMAAGMTPSGMSGPPMGMNQPRPPGISPFGTHGQRMPQQTYPGPRPQSLPIQSIKRPYPGEPNYGNQQYGPNSQFPTQPGQYPTPNPPRPLTSPNYPGQRMPSQPSTGQYPPPTVNMGQYYKPEQFNGQNNTFSSGSSYSSYSQGSVNRPPRPVPVANYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGDNKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSGNTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKRFKTMSPSQMIMPNVMEMIAALGPGPSPYPLPPPPGGTSSNDYSSQGNNYQGHGNFDFPHGNPGGTSMNDFMHGPPQLSHPPDMPNNMAALEKPLSHPMQETMPHAGSSDQPHPSIQQGLHVPHPSSQAGPPLHHSGAPPPSQPPRQPPQAAPGNHPHSDLTFNPSSALEGQAGAQGASDMPEPSLDLLPELTNPDELLSYLDPPDLPSNSNDDLLSLFENN
The following text describes a protein:
Function:
Exhibits natriuretic and vasodepressant activity. Has cGMP-stimulating activity. May help to regulate body fluid homeostasis in a variety of aquatic environments.
Subcellular Localization:
Secreted.
Sequence:
MNLSYLVACGLLVTFLSDKMDAQPLTPAQQKSLRSLLGEELAEFLESGENENRLDDVRSRMRLLRDLRVDTRARGMWARLLNDQPASRRHKSGSKKGGSTSRSGCFGHKMDRIGTISGMGC
The following text describes a protein:
Function:
Adenine glycosylase active on G-A mispairs.
Sequence:
MRPDSSSPSIYSVSDSDSSDYAPSVSETKRSSIKRKRAAPASTKSRTKTTIVKQARGKGKAVDNIEDIENLGATVSRRHGMDYHSVDKIVDEKESLLEWFECVREKRGMPWRKKYDPSLSFEEKGQRAYEIWVSEVMLQQTQVTTVIAYWQRWMERWPTISDLAKADVEEVNAAWRGLGYYRRARSLLAGAKTVMGNSKYNGRLPDDPAVLEKEIDGVGRYTAGAICSMAYGVRTPIVDGNIHRLLTRLLAVHAPQTGPATIKFLWRVADELIKHLPSGDKHNNVVGDWNQALMELGSQVCKPANPECGVCPLKKACKGYAELSNSPSQPSTTKSDCKLCAPIPCDIETDRIPTVMVFPMKKEKKASRVEEETVCIVQWRGDGDQRRWLFTKRPEKGLLAGLFEPPTTPVSAGLSSSERLGASLEALSDYIEITEGEAEGLQKSSRDVGNIPHIFSHINMTYHIHLLTLTSPGNEPPSVKPKAPRPAVWLNEEEVEKANVGTGVKKVWAEIYGSWGSFEESEAGAILAKKQKRTNNKLTKPKPVVANRNEKIVKKVMMPPMPTTRKNVVDAVE
The following text describes a protein:
Function:
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
Sequence:
MNKAEFIDLVKEAGKYNSKREAEEAISAFTLAVETALSKGESVELIGFGKFETAEQKGKEGKVPGSDKTYKTEDKRVPKFKPGKTLKQKVEEGK
The following text describes a protein:
Function:
Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Subcellular Localization:
Cytoplasm.
Sequence:
MLKIYNTYIHIPFCERKCNYCDFTSLKGTDSQIEKYINYLLKEIEIYSKEYDLSEKQDTIYFGGGTPSLLPINSLEKILSKFSYDKNTEITIEVNPKTVDTNKLKEYRKLGINRLSIGIQTFNDDNLKVLGRIHSSQEAIEVYNLARECGFDNISLDIMFSLPYQTLSMLQNDLEKLVSLNPNHISIYSLIWEEGTKFFRDLKSGKLKETDNDLEASMYEYIIEFLKSKDYIHYEISNFSKKDFESRHNSTYWENKKYLGVGLSAAGYLNNVRYKNFFNLKDYYNNLDRNILPIDEKEILTEEDIEQYRYLVGFRLLNKIIIPSEKYLEKCMSLCKEGYLLEKENGYILSHKGLMLFNDFISNFL
The following text describes a protein:
Function:
Proposed to synthesize NOD factor fatty acyl chain. Involved in the synthesis of a highly unsaturated fatty acid moiety, which forms part of a lipo-oligosaccharide that is responsible for host specificity.
Subcellular Localization:
Cell inner membrane.
Sequence:
MRKYIIKIYYFLFFYVLQVNSKRYAFIKRGIPGISKNYFKGFKLYNSREMKNLCETSRVVCTGVGVVTGLGIGIEHFWNNIINGYTSIDKITKFDITGMSCGIGSEIKKSDFNPSDYYTNKKDVNRNDDCTHYAVAATRLALDDAKLNLEKLDKDKTGTIIGSGIGGLRFLEKEMKTMYEKGHKRITPYLIPAMIANTPSGYVSIENNIRGISLGMLSACATSGNTIGEAYRYIKYKEYDVMICGGTEASITPISFAGFNSLKALCTGYNDNPKKGCRPFDLKRSGFVMGEGSGILILESYEHAIKRNAPIYGEIISYSSECDAYHITAPEPNGKGLTNSIHKALKNANININDVKYINAHGTSTNLNDKIETKVFKNVFKDHAYKLYISSTKSMTGHCIGAAGAIESIVCLKTMQTNIIPPTINYEYKDPDCDLNYTPNKYIHAKENIDISLNTNLGFGGHNTALLFKKIVK
The following text describes a protein:
Function:
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
Subcellular Localization:
Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein.
Sequence:
MEQFNPSLRNFISMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRNKGDSLEKCQAELKKLRKKSQGSKNPQKYSEKELQFIEAITNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNALTYHSKGKDILTQKLPLWQQSCADPNKIPDRAIQLMQQMALSSNGTIMPSPLTTSKSNLIISDPIPGAKPLPVPPELAPFVGRMSAQETMPVMNGVSGSEGEDYNHWSDRKPPQPKSLSPPQTQKLSDSYSNTLPVRKSVMPKNSYAATENKTLPRSSSMAAGLEKNGRTRVRAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKLRGWFPFSYTRVLDSEGNDRLHISQGKSSSTGNLLDKDDIPPPDYSMSSRGFQSQNVSTFKQRPYSVAVPAFAQEYLMPYGCAINEYSSGLCPMLPASYQPYPRSTAGLDDYGARSSSRNPFANVQLKPTVTNDRSAPLIS
The following text describes a protein:
Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
Sequence:
MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLIKTAVDKIDIDTPNWSFVASRLFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKFDLEFLNSQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIELPQHMFMSIAMFLAQNEQEPNKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSKYGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIWHIDVMEFIDLRKNSGDERRRAHDLFPALWVCDLFLKRVLEDAMWTLFDPYECKDLTELYGQDFEKRYLEYEKDPKIIKEYINAKDLWKKILMNYFEAGLPFLAFKDNANRCNPNAHAGIIRSSNLCTEIFQNTAPNHYYMQIEYTDGTIEFFEEKELVTTDSNITKCANKLTSTDILKGKPIYIATKVAKDGQTAVCNLASINLSKINTEEDIKRVVPIMVRLLDNVIDLNFYPNRKVKATNLQNRAIGLGVMGEAQMLAEHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVYKDFENSEWSKGIFPIDKANNEALKLTEKGLFNHACDWQGLREKVKANGMRNGYLMAIAPTSSISILVGTTQTIEPIYKKKWFEENLSGLIPVVVPNLNVETWNFYTSAYDIDAKDLIKAAAVRQKWIDQGQSLNVFLRIENASGKTLHDIYTLAWKLGLKSTYYLRSESPSIDEKSVLDRSVECFNCQ
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular Localization:
Cytoplasm.
Sequence:
MANTKKSAINQVVTRDYTIHMHKRLYGVSFKKRAPRAIKEIVAFAQKHMQTKEVRVDPSLNKEVWKRGIRNVPHRLRLRLSRKRSDEDDKALYTYVQAVDVANPKMETTVVEE
The following text describes a protein:
Function:
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Subcellular Localization:
Secreted.
Sequence:
NLYQFSNMIQCTIPGSDPLSDYGNYGCYCGYGGSGTPVDELLRCCQVHDD
The following text describes a protein:
Function:
Involved in the biosynthesis of kanosamine (3-amino-3-deoxy-D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the reversible pyridoxal phosphate-dependent transamination of 3-dehydro-alpha-D-glucose 6-phosphate to form alpha-D-kanosamine-6-phosphate. It can only use alpha-anomer and glutamate is the only amino donor.
Miscellaneous:
MISCELLANEOUS: The production of neotrehalosadiamine is dormant in the wild-type strain. A mutation in the beta subunit of RNA polymerase activates the production of the neotrehalosadiamine.
Sequence:
MQKQVKISGKSKENMSLLKHLKGDVQGKELVIEDSIVNERWKQVLKEKIDIEHDLFNYQKNREISKVPFLPVDRLITNDEVEDILNTLTEVLPTGKFTSGPYLEQFEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLASGGVPIYVDINPQTFCIDPDKIEEAITPYTKFILPVHLYGKHSDMQHIRQIANRYKLKVIEDACQGIGLTDLGKYADITTLSFNPYKNFGVCGKAGAIATDNEELAKKCIQFSYHGFEVNVKNKKVINFGFNSKMDNLQAAIGLERMKYLSLNNFKRLFLADRYITQLAELQNKGYIELPELSEDHVWHLFPIKVRTEDRADIMTKLNEDFGVQTDVYYPILSHMQKTPLVQDKYAGLQLVHTEKAHSQVLHLPLYPSFTLEEQDRVMEGLFHVIKQEIGV