lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the pex1-pex6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the pex5 receptor from peroxisomal membranes, an essential step for pex5 recycling. Specifically recognizes pex5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the pex2-pex10-pex12 retrotranslocation channel. Extraction by the pex1-pex6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from pex5.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MRCIVSYKSLRSCLVNVPELLLESISEPVQNYAVQAVVCKNDIKKTFYFGISGIPSQFSFEIDSTYAHTLKLAENQEINLSIIDCTHEIEQLEIEPVTSNDWEIAERNAAWLEENLLVQYRVATTERFIIYLPSGTFIQFQPLKLIPSSLCGRLLRTTEVLITPKPNTSAIEVKENRKVNLRCVVENRLLPDSVTADSPALCVFLPLNFPDRPDVVYMDGGNLKSTIVCQCVSCPFQIPGHFFISKSLALSYSIKTGFKFQIWKAHNPPSSSKFILEQKGLPPESNLSSELVAAKLKNSYLMDGMTLKLVDIAVSYSVSGLSGVVKNPIQDIKITSDTNVPVNAGIRNNSPRLSMQPFPHEFAQVRNAVFLHQNIYINGPKGCGKSNLVHSLFDYYSLNSIYFQMIVSCSEIDRSSFAKFQSFWNNVFIQAERYEPSIIYLDDVHCLISSSNENGELGFVEEREIAFLQHQIINLKRKRKIIFIGFGEEFLTFSENLVLPLLFQIKIALPSLAVTRRKEILTTIFQENFSDITMDSIEFISVKTEGYLMTDLVLFVKRLLSEAFVEKIQNGPKHLMNKGLIEKTLKDFVPLQLRKAKFVKSSIRWIDIAGMQEAKEAVRDIIESPVKYSLIYKQCRLRLPTGILLFGYPGCGKTYLASAISSTFPVQFISIKGPELLDKYIGKSEQGVRDLFSRAQMAKPCVLFFDEFDSVAPRRGQDSTGVTDRVVNQILTQMDGAESLDGVYIVAATTRPDMIDPALLRPGRLDKLIFCDLPNEEERLEVLQKLANRFHIENAAMLKKLSTLTDGYTYADLSSLLYDAHLIAVHKLLKRVSINAVDPSQTTSSFTNLTTESKRNASMLALPPESRYNQNMQSMSDSKSVVIEDYMLMEALKKNSPSLNSEEFEHLSNLYRDFRSKLFEPELNARNTDVGSKTRQI
The following text describes a protein:
Function:
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPMETGFTSPGPLIVQIGGFAVRWYSLLILAGIIAGTLLSQKLAPERKVAPEVLSDLVVWLVVGAIPMARLYYVLFEWQRFAGEPWWKVFAIWEGGIAIHGAILGGLLAGWLFCRRNGYSLLTMIDLAAPGLILGQAIGRWGNFFNSEAYGAPTNLPWKLFIPEANRPPGMAAFAYYHPTFLYESLWNLGVLALLLFVFFRFKNLRPGSIACLYALAYSVGRFWIEGLRLDSLMVGPLRTAQLVSLAGIVLGAVGLWWLNRRSARQEAP
The following text describes a protein:
Function:
Peptidyl-tRNA hydrolase involved in the recycling of tRNA-Lys from diacetyl-lysyl-tRNA-Lys and is important for mitochondrial function.
Subcellular Localization:
Mitochondrion.
Sequence:
MAIKHLPKILIARKNKAEVNHCDLKRRVSIKIIYGLGNPGSAFVKSRHSLGKLMVSMYADSMAFPKNWPSTKENLTLVLSTSYMNDSGKQLKKISNDFVRKVSPLDKIVYVVVHDELELDLGKVKLRLPGGSHRGHNGIRSCQEFLGKESFYRIGLGIGRCESRNREDVSDYVLSKFNSNEMKLIETDIFHKFCNILQQLQLSIET
The following text describes a protein:
Function:
Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth (By similarity). In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.
Subcellular Localization:
Perikaryon. Cell projection, axon. Cell projection, growth cone. Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, lamellipodium. Note=Localizes in multiple growth cones at neurite tips before the neuronal symmetry-breaking step. Accumulates in growth cones of a single nascent axon in a neurite length-dependent manner during the neuronal symmetry-breaking step; when absent from the nascent axon's siblings, probably due to competitive transport, prevents the formation of surplus axons. Transported anterogradely from the soma to the axon growth cone in an actin and myosin-dependent manner and passively diffuses back to the cell bodies. Colocalized with L1CAM in close apposition with actin filaments in filopodia and lamellipodia of axonal growth cones in hippocampal neurons. Exhibits retrograde movements in filopodia and lamellopodia of axonal growth cones (By similarity). Colocalized with KIF20B along microtubules to the tip of the growing cone in primary hippocampal neurons. Recruited to the growth cone of developing axon in a KIF20B- and microtubule-dependent manner.
Domain:
The N-terminus region is necessary for interaction with actin retrograde filament flow and accumulation in neuronal growth cones.
Sequence:
MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDDDPATDTDAAAETCVSVQCQKQIKELRDQIVSVQEEKKVLAIELENLKSKLGEVMEEVNKVKQEKAVLNSEVLEQRKVLEKCNRVSMLAVEEYEELQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSLPDQQLLKALDENAKLIQQLEEERIQHQKKVKELEERLENEALHKEIHNLRQQLELLEDDKRELEQKYQSSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGNSAKKEKTTQPETAEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKAKPDSLKGSESAVDELKGILGTLNKSTSSRSLKSLGPENSETELERILRRRKLTAEADSSSPTGILATSESKSMPVLGSVSSVTKSALNKKTLEAEFNNPCPLTPEPGEGPRKLEGCTNPKVTFQPPSKGGYRRKCVGSENQAEPVVVLDPVSTHEPQTKDQAAEKDPTQFEEEGGETQPEYKEDSGGKTGETDSSNC
The following text describes a protein:
Function:
Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance. Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex to regulate dendritic spine distribution of the STRIPAK complex in hippocampal neurons.
Subcellular Localization:
Cell projection, dendritic spine. Cytoplasm, cell cortex.
Sequence:
MATKNAEIGAASKNGENTSPEPSKKAAAKAAAGPLKSLADLEKGDLLRLLGILEAELQARELVILKMRSDKARSAIMQERYGKLALEDPFSALNRDAQEASEEVHDNSPVYASAMVHLEALITQQKKTHQKMMIQMTAAEKRHKKVVHELEEEKRKHAQDTAQGDDVTYMLEKERERLSQQVDFEKSQARKMEKDKNKAMAMLEEERAHHQQIGVLLAKERKRLASKLIQERQQLKDAHQGLQDEKDKVRNMAEGLVQESKKSLKMEAEMEKQISEFDIEREQLRSKLSREEAKNRDLQTEVDEYRKQLEDMRKSLLKGATGDTVKPRAIMRSAGTQTENPPENEVRRREGATAAESKNYVSTVKKNLLRGAENTDVEKATKETRKSSPWLKNAPDKPVVSAWGPNPFPCTSIETEHHGKVDMESSSDSEDDKTVIENVPPVSFKAGMVASSSGQGSPSPTSSTSTLSPYSRVQSTKLLFSPKGSTRTTSSSSSPSSSSSTSPSPESPNTSVTVGGTGSMVTKAVFKFSGDQDTNRTHLKGYSTAGSPTLKVSNADSSSELAITESNKTAERSPDAKVTSPSAKALGSLIVSPTSVSPGARRLPGKGPPPIPKKPLHIPQPNPALKDGRNSPGVGMKLEVRKQAVAAPIKSVATTPPTPKSGYGRGSSGSSGSSTSDSDNSPNSPHPVIPGTTRVGQRYSTPLSNIAYNRNTGIRSTSQSPSSNNNRPSTLATNKSGSVSPSSQSAPSSKSASQSGNKAEAEQPTSKKTSQVGADPSPSNAAAPPIHDDFSSDMAEIHQLLTEMMADGTSGITGEPGPASALPVEMSNSSPSRLSPSDSPRKLSTLKIEIGGGSMLDAGRETHTTSNFLYLPAEKESQCFESLDNNNTVPKDAESTTEHSNSDDDKGTVKGEVAELCKTLLKKGGLGEEAPVRGIPNRLHQAAGEGDMTMVEQLLEEGADPNTTERDGSTPVYAAAEGGHIDCLELLLSHNGDPNALRDDNFTPLHGAAAEGHTGCLKLLLDRGAHPGLPDKAGWSPLYWAVSNGHTDCCRTLLDYFASRAAVTDVGWTPLHGACRSGHVSCLKVLLYYDPLNSDGQDEATLLTTRPALVSKDVINAVDRDGWTAAHVAASRGFKECLELLCGHPELDLTIRDKWDRLVQDVAVGDCRGLVEDIGKRKVSVVIDTSSETMVTGRTTPTPSVKEEDLYVLGSLTLERGTDWSQFDADVGAVLVQNSRKLSVASELLTELEEVDTDISADGHVSELGLTANSIRSYTYGTISWSPATVFDTTPYDFFTAKKHLAIRLKGPDEDCVDKLSYESMIPVQTLQNYLRLIEQYKSVVFYGPPGTGKTFIVRKLAECIRNKQLQSGFQADISHVALNPKYTHKDLLQLLRSKGFLLPSTPASTAEGVQKAPILILDDLGRVSLSEVLGELLYALEYRGPQHPISMKIDEEGPTDEDGSSSAYYLSEDCYIIGTMDKSRSPGLDLSVQQRFRWVHLKCDSEPVKGLLQRHLRRRLISAHGGQLPSTDDQVYKAVEWVAAVWQRLNACLAKLGLPDLVLGPRHFFTCPIEATKVKAILRWLSLSWNHAIAPGVEDAMLRGLSSQNQQKLASTALSVLLQRAVIPGCPLSGQEAERYLSSFRGGYEGMVSLLNTAKRSAARAKRTRSAWKKSASANDSDGQDSDSTAAEGDSGVDSPESPLSPTGPPSSTLTGSPSKKRPTSELARRVIENLHASHHASSPDLRSAGLSNLAYLGASAMDGDVLKMLLKMQTSKSESNLNTVIELHDHIFNMHSR
The following text describes a protein:
Function:
Possible role in regulating endocytosis of the transferrin receptor at the plasma membrane. Alternatively, may function as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity).
Subcellular Localization:
Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus (By similarity).
Domain:
The SH3 domain mediates localization to the clathrin-coated pits and vesicles.
Sequence:
MAAQKIRSANTNGLPRCKSEGALIDFSGVPDPSLSEVKVLSPSSLRIDNPASLENVKEVVAIKDYCPNNFTTLKFSKGEHLYVLDASGGDWWYAHNTTEMGYIPSSYVQPLNYRDSCLSDSGMIDGLLESVDEGVKELDLLGDWTNSSNQDSVKKCHNNPFLRPSVSNPFLNGPLVPQTHTADTENSVDLLLFDPLAPSHAIASETSTDVLLDLLPNTSQNEVTVPVKRDNPFFRSKRSYSLSELSVLQAKSESPTTGSFFAGLKSPAPEQFQSREDFRTAWLNHRKLARSCHDLDLLGQNPGWGQTQPVETSIVCRLDSSGGAVQLPDTSISILVPEKHVASGETQQISLKALLDPPLELNNDKCTTVSPVLEIKLSNMDVQSPLTLEVRISVALGGNASALNMVGIKCLRSDAKEGPYNSVTQIYMYGDTVQVKLDNLEPVMYVVMVAQGQGIVSPSSVWEYINKKVTVGLYGPKHIHPSFKAVIVIFGHDCAPKSLLVNEVGQQANKSAPVTLQLWGKQQFVLPKPQDLQLCLFSNMTNYRVDAGDQGKMVRGFQLKLGKVSRLIFPITCQDSAQLSDFTLRVQVRDEAGGVLSQYCVQTPQPPPKTGSKSTGPRRFLKKKEVGKIVLSPLALTYKYPTFQDRPVTSLKYGKLIKTVVRQSKNPYLLEYKKGDVIGLLSEEKIRLKGQLWNKEWYIGYYQGKLGLVHAKNVLVVGKVKPSFFSGPELTTGLLLEQILRPCKFLTYIYASVRTLLMENIGSWRCFADALGYGNLPLSYFCRVELESETERVASVLEKLKEECNSEGKEKKSFQKELIMALLKIDCQGLVVRLIQDFVLLTTAVEVASRWRELAEKLARVSKQQMEGYEAPHRDRNGMLDSEAMWKPAYDFLLTWSAQIGESYRDVIQELHTGLDKMRSPITKRWKHLTGTLIFVNSLDILRAAAFSTQEPEDCII
The following text describes a protein:
Function:
Involved in the mineralization and structural organization of enamel.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MELLALVFCLISTAIAYPMHQHTPGTQGLASISLETMRQQAADTLTAPLSQISRFGYNDPYSVLWLHGLLPPHSSYPWLHQRPQLSDNQQFEYALPIHPPPLPGAQSPAQTEKAGQHTQNIPQQPQAAASTDQLSHQPSLPLGFPILQQADPAITPPKGGPVDGQIQTVALYMYQTIMNKLLQQGAGEMMPDPASTPPVHQQHPYPGLFFMQYGGGPGGPPARLGAMSSEEITGGRAGAAHAFSSLYPGLLGMGPGPGSQPQNPALQGDFTIEDDSPIAGGKPTVFKGPIETPQAVGPSLIIPGSEGNPNGQGETVAFPNINLPNFAFNPQSQSKLPPGVTPANAPRLTYDTGAGFVPFALDDTIPFSVQRENVITGEMTQANNAKTIDSPIMREVHLQNHNNYFQEP
The following text describes a protein:
Function:
May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. May also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDGVKEWFNSIPPVSRYMFAIFLGIPVLAAMHLISFNYLYLDFTFTFKHFHLWRLITAPCIISSLGPMFLFNLIFFYQYTTRLESLNYAGKSDDYLFCIIFISICNIIFGLIFEYYFLGTMTIMSLIYIYSRMNPTGTSNFYGFFSFKTIYLPWVFLVAHFLQTGHPPYSDFLAIVSGHIFFYLTDIYPRANGVPALIKTPKFITNIFNKGDRNPNNVRRDPRTGRPIQEGGYNWGQGHALG
The following text describes a protein:
Function:
bHLH transcription factor that binds DNA on specific sequence 5'-CANNTG-3' in target gene promoters. Negatively regulates brassinosteroid signaling. Together with BHLH148/RITF1, regulates the transcription of several genes involved in the detoxification of reactive oxygen species (ROS) generated by salt (NaCl) stress. Confers tolerance to salt and to the oxidative stress-inducing reagents hydrogen peroxide H(2)O(2) and methyl viologen (MV).
Subcellular Localization:
Nucleus.
Sequence:
MASLISDIEPPTSTTSDLVRRKKRSSASSAASSRSSASSVSGEIHARWRSEKQQRIYSAKLFQALQQVRLNSSASTSSSPTAQKRGKAVREAADRALAVSARGRTLWSRAILANRIKLKFRKQRRPRATMAIPAMTTVVSSSSNRSRKRRVSVLRLNKKSIPDVNRKVRVLGRLVPGCGKQSVPVILEEATDYIQALEMQVRAMNSLVQLLSSYGSAPPPI
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSSDTAASCLLDIVVFAGGDSLDLMPLTAVEQKTMLRICNRPLIWYAITPWIEAGFRCFFLCVNEDYATLRAYLSRAFDGVDFHYILVPSNMGDHPSTTCDAVKAYLKYKEALRLGEEGTLAEVSRGMPDRDDSAINVEVSGGRSPSVMSLHEAQQHRGASGSRNHGGSTSHSNRDPLKLERMNSAGLPRDALLLSCDTILVDVDVASFVERHYASLASVTAMLYRPLRKRGGSGDHKGGHRHGKGGGGASADSAEVSYTHALSCVAYEETDVLASMGLGAASSAPTSSCSRRLPSGMPSQSLHASASLFARSPCEVRTMSAEPVHVHHHRMHYLNPLEGKPEVRITMAFAARRPDLTFAADVVDAHAYLMSRWVLEFIAESAGVSDMSVRKDILPLLARSQHTTVNAAEKVFVTPADKLKMNVPLHWLGEGAEISAQSLNAACGLSLPEVTDSLRVFCTIYEEDPDVACRICSMNTRDNYRALNHDIISAKCSQLQLEEPPLGTGSAAGVGGAFGGGTSAVNRFALPSLLPHGGAHAGHTGAAGGAAHGDSGKPAPSAGAVALSSLLPDNPITLREKIGDQQVCIVGSFIDSVPPPNVFVTRSVIGAHVTLEPGVRITDSILMGNVEIGAKAVVSNSVIGTGAVVNAGCRVVGTIVGPRCVVEENASDTIIE
The following text describes a protein:
Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.
Subcellular Localization:
Nucleus.
Sequence:
MHTAGGWETRLHRVQGIMATKKLRRAKLSQELCERLSRYQITTCQDFLCLSLLELMKVTGESYRNVQKLLRKVSLACAPKMQTAYEMKVRRSINPSAAFLPTSLHSLDKVLHGGIPCGSLTELTSPPGCGKTQFCITMSVLATLPVSMGGLDGAVIYIDTESAFSAERLIEIAGNRFPTYFDSDEKLFCMTRSIHLYRELTCDSVLKRIKSLEEEIISKKIKLIIIDSVASVVRKEFDTKLQGNLAERSNFLARGASLLKYVAEEFSIPVILTNQITTSLSNGLAIPADLVSPAHDLSLSEVTGASGSGKKESACVTAALGNTWSHSVNTRLILQYHDLLTRQIVIAKSPVAPFSTFFYTVEKSGLVLQDGKNLSNLPWEGTNPALQTIQVRNTALGNALLKTTDETPGDTPSP
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which transfers ubiquitin to substrates promoting their degradation. Part of the nuclear inner membrane (INM)-specific branch of the ER-associated degradation (ERAD) pathway, required for the elimination of misfolded proteins in the INM, a specialized ER subdomain. Required for ERG11 degradation. Negative regulator of SPS-sensor signaling. Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals. Controls amino acid permease (AAP) gene expression in response to amino acid availability, a process mediated by the transcription factors STP1 and STP1.
Subcellular Localization:
Nucleus inner membrane; Multi-pass membrane protein.
Sequence:
MNSSTSSENVFINSFSYLNQTSQAVISGNSTFANVINFPYRLGLSFIGAVNLQYEQTVKSEEIPPTLRSVFDTIGFFFSPYAIFCFVIAIVLNRFVVFYAVLNNGSRRTLPLWLSNVFHVSAVVVLAMVSLGPLTLGKDFKILGDPAFAQEKFLLNIFYAFAYSYCVETIFTIMRNSSPLEGTDYSLFELSIQFYTMTNNNTKFLDSPDYIIDCSMAILSRILIHLVEIFRLRNYRLLFSTIMNLCHICYLGIRVKQGGWKSLPFSVKFRHFPKLFSVSIICLSLLIFKLSCLIRWDPFGKSRNSCELLQFYPLSRNWKKYLNYTGEEDFSAMATKFALLLCSGTELMEKGIRREFPAINIPDNVNEKFFISGYLNELSKPYKENTSISFPKKNSSILKQRFFLMFPKSIIWIMKKLVGQVFFGFRDNKDEDIPDNDPSKMLKITKTNSLNNSAGHKEDIELELLNTSDDEYSEDYEPSEVESLGDSDEENLEEDSLIFNETRDALLDLFSSEDNEVHTDYNWIMSTSRILQQKLLSDKTLTRASILDTKLSEVDETFGTESDFDLSCAVCKVNERNTVLWPCRCFAICEDCRISLGLRGFSTCVCCRSKVHGYCKVHPVSDSK
The following text describes a protein:
Function:
Required for mating and morphogenesis. May contain a cryptic binding site for cdc42 that is enhanced by binding Ras. Interacts directly with scd2. Promotes the exchange of cdc42-bound GDP by GTP. Involved in septation and stimulates the elongation of conjugation tubes.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Located at the growing cell ends and tips of conjugation tubes.
Sequence:
MAYFQDRKTSSRSLPSYINHSTQNLVGPRKDETNLSEYMKLRLLQSPSQVIYNLENTVSLYRRCLNLRKRLMDISELAAFFDSIHREALNSSFKILEFKDIEFDDPVTEIWLFCRLGYPLCALFNCLPVKQKLEVNSSVSLENTNVCKASLYRFMLMCKNELGLTDAALFSISEIYKPSTAPLVRALQTIELLLKKYEVSNTTKSSSTPSPSTDDNVPTGTLNSLIASGRRVTAELYETELKYIQDLEYLSNYMVILQQKQILSQDTILSIFTNLNEILDFQRRFLVGLEMNLSLPVEEQRLGALFIALEEGFSVYQVFCTNFPNAQQLIIDNQNQLLKVANLLEPSYELPALLIKPIQRICKYPLLLNQLLKGTPSGYQYEEELKQGMACVVRVANQVNETRRIHENRNAIIELEQRVIDWKGYSLQYFGQLLVWDVVNVCKADIEREYHVYLFEKILLCCKEMSTLKRQARSISMNKKTKRLDSLQLKGRILTSNITTVVPNHHMGSYAIQIFWRGDPQHESFILKLRNEESHKLWMSVLNRLLWKNEHGSPKDIRSAASTPANPVYNRSSSQTSKGYNSSDYDLLRTHSLDENVNSPTSISSPSSKSSPFTKTTSKDTKSATTTDERPSDFIRLNSEESVGTSSLRTSQTTSTIVSNDSSSTASIPSQISRISQVNSLLNDYNYNRQSHITRVYSGTDDGSSVSIFEDTSSSTKQKIFDQPTTNDCDVMRPRQYSYSAGMKSDGSLLPSTKHTSLSSSSTSTSLSVRNTTNVKIRLRLHEVSLVLVVAHDITFDELLAKVEHKIKLCGILKQAVPFRVRLKYVDEDGDFITITSDEDVLMAFETCTFELMDPVHNKGMDTVSLHVVVYF
The following text describes a protein:
Function:
Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MASTSAAASTTAPSSSPSTPTPQPQSSRKYNLHNPLPLSAAQEAEVKQLYYKRVRAHCAPEIKAFAECAVNRTVTATWVCRAQRLAMNSCMVAHAKPEEEDRAREEWFATHEERRRAREEELARVEKRREEVIRMMREDEARRKKRSS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Sequence:
MIKVLSPAKINLGLWVLGRLPSGYHEILTLYQEIPFYDEIYIREGVLRVETNIGIPQEENLVYKGLREFERITGIEINYSIFIQKNIPPGAGLGGGSSNLAVVLKKVNELLGSPLSEEELRELVGSISADAPFFLLGKSAIGRGKGEVLEPVETEISGKITLVIPQVSSSTGRVYSSLREEHFVTPEYAEEKIQRIISGEVEEIENVLGDIARELYPEINEVYRFVEYLGFKPFVSGSGSTVYFFGGASEELKKAAKMRGWKVVELEL
The following text describes a protein:
Function:
Catalyzes endohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan with retention of the beta-configuration of the glycosyl residues. Specific for xyloglucan and does not hydrolyze other cell wall components (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MKLSLSVALSLAASTAQAATQFCDQWGSVTEGNYILYNNLWGQAQATSGSQCTTFESLSGNTIVWNTKWSWSGGQGQVKSFANAALQFTPKKLSSVKSIDSTWKWNYSGSNIVADVAYDMFLSTSPGGDHNYEIMVWLGALGGAGPISSTGSPIATPTVAGIKFNLYLGPNGSMQVYSFVAQSTTNSFSGDMRDFFTYLESNQGLSSDLYLVDVQAGTEPFSGSNAVFTVSDYSVSVA
The following text describes a protein:
Function:
Catalyzes the epimerization of L-Ala-D-Glu to L-Ala-L-Glu and has a role in the recycling of the murein peptide, of which L-Ala-D-Glu is a component. Is also able to catalyze the reverse reaction and the epimerization of all the L-Ala-X dipeptides, except L-Ala-L-Arg, L-Ala-L-Lys and L-Ala-L-Pro. Is also active with L-Gly-L-Glu, L-Phe-L-Glu, and L-Ser-L-Glu, but not with L-Glu-L-Glu, L-Lys-L-Glu, L-Pro-L-Glu, L-Lys-L-Ala, or D-Ala-D-Ala.
Sequence:
MRTVKVFEEAWPLHTPFVIARGSRSEARVVVVELEEEGIKGTGECTPYPRYGESDASVMAQIMSVVPQLEKGLTREELQKILPAGAARNALDCALWDLAARRQQQSLADLIGITLPETVITAQTVVIGTPDQMANSASTLWQAGAKLLKVKLDNHLISERMVAIRTAVPDATLIVDANESWRAEGLAARCQLLADLGVAMLEQPLPAQDDAALENFIHPLPICADESCHTRSNLKALKGRYEMVNIKLDKTGGLTEALALATEARAQGFSLMLGCMLCTSRAISAALPLVPQVSFADLDGPTWLAVDVEPALQFTTGELHL
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAAEESKIKNVAIASDDSQSIEKEEEIKHEKETDLGISLDKLSLGPKKKLLVIPLGGLIVHRAHVRDRATLPKNRRPDLTYGKFKVYKRPFCEEFLRFCFERFEVGLWSSAMEHNIDKVLTQIIGELKTKFLFTWDQNQCTKTRFTCFGNDYKPLFLKELKYIWEKKYSSGEYSSSNTLLITDPEKALLNPVLFYIFNLIFYLLINTAIFPKEYDIKNKNDDFLGPNGELRAFLDGLADAIDVPSYVKDNPFGEAAITPSHPHWDFYSEIISSGGKEESSDDEFWDSDWSY
The following text describes a protein:
Function:
Daughterless/Achaete-scute complex heterodimers act as transcriptional activators of neural cell fates and are involved in sex determination.
Subcellular Localization:
Nucleus.
Sequence:
MATSDDEPMHLYEVFQNCFNKIANKQPTGTVGADRGGGGGYHSPYGSLGVENGMYPSDFNSMHDTVNGGNNRYANASTVDQYFDSAAAGSGGAWCQPQMSSANSYMGQSAYQNSGPLSGHSIDQQQQQVHQADGLGMGGGGGGGVGADGMHCPVTTGLPPISSFRPTSGGIGGPGAGQQAPVNVNVNPPAVFNSPQAHNHNHTVQAQHSALSTAGPLGHHSLNHTPHAHSHTLPLPHALPHGHTLPHPHHSQQNSPAVQSSDAFSGAGASVKVAGAGNSSAAALRQQMYMPADQSISSFGSNPSTPVNSPPPLTQSVVGGGGEPSVSGGSGWGHSVLNGGPSSSYASEMVPVSSLHTMASVFQGVRMEERLDDALNVLRNHCEPEMLAGVNQSLASIDNIDALTSFVPNSPSHLGSGGNSGSVSNTSNAALVHEVLALGAAAAAGTSGQSVGGAGSLASLKLDRSASTSLPKQTKKRKEHTAISNSVPAGVSTTSSLTSLDISDTKPTSSIESSNSGLQQHSQGKGTKRPRRYCSSADEDDDAEPAVKAIREKERRQANNARERIRIRDINEALKELGRMCMTHLKSDKPQTKLGILNMAVEVIMTLEQQVRERNLNPKAACLKRREEEKAEDGPKLSAQHHMIPQPQQVGGTPGSSYHSQPAQLVPPSSQTISTMTISLPVNQANNGLPPHLQQQQQQQSQLGHAQLPQ
The following text describes a protein:
Function:
Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues (By similarity).
Miscellaneous:
MISCELLANEOUS: In contrast to group 1 and group 2 endotransglucosylase/hydrolase proteins, it may not contain the ligase activity, and may catalyze endohydrolysis xyloglucan polymers only.
Subcellular Localization:
Secreted, cell wall. Secreted, extracellular space, apoplast. Cell membrane; Single-pass membrane protein.
Sequence:
MKIMWETAVVFCLCSLSLVSSHSRKFTTPNVTRLTDQFSKIAIENGFSRRFGAHNIQVNGSLAKLTLDKSSGAGLVSKNKYHYGFFSARLKLPAGFASGVVVAFYLSNAETYPKSHDEIDIELLGRSRRDDWTIQTNVYANGSTRTGREEKFYFWFDPTQAFHDYTLIWNSHHTVFLVDNIPVRQFPNRGAFTSAYPSKPMSLYVTVWDGSEWATKGGKYPVNYKYAPFVVSVADVELSGCSVNNGSSTGSGPCTKSGGSISSLDPVDGQDFATLSKNQINAMDWARRKLMFYSYCSDKPRYKVMPAECN
The following text describes a protein:
Function:
Component of the phosphoenolpyruvate-dependent nitrogen-metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein NPr by enzyme I-Ntr. Phospho-NPr then transfers it to EIIA-Ntr. Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MIRQKVRVMNSTGLHARPAATLAKIVKKYQSSLTLVNNDKEIPIKGMMSILGAGVKGNTMIDLICDGQDELAFMDELKSAFADGFGESV
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, flagellum axoneme. Note=Localizes to the A-tubules of DMTs.
Sequence:
MEVIHGQPYCCRELEGADILSDTFYSNELHTPLETATRPTASEDRYQKFRQSLQRCRLPWGAEREYGGMIPISLPEEHRPKCEPPRVMGKGHQHYGFGGEIWPRKLPIEQFYYLSQNKKSDIYGNDSLLPKPPNSTVGEICSPYPIEHPYHTHISRGAMFPTFTSPKDLYTGIKARTQQPFPPTVPTKPYDTTVLKTRGNPYRYELLDFPMDSKKKALVWPGQRVYFDLPKCVEKNKPVFYPKPPKTFAPNTSLNSWDPITSLKEVNIQRNLEKSHWITSYNHDFTGLGPMNPLELDDYHEKEVAELTGQIGFDPEPQEKVHPALKPTRPLEGRIARLIQNQRPLEAILEQRPSSCPDCTPRVLCTFHTFVPSSTEMMALSDNIPADVTHKNQEIEEKIKEEQSLLSTYALPSCYPTKDLANTYDIKPFPKITDTKKTEDLYWRQLSLKPQLIPYCNPDHYIPYEHLNQYNVYQNPVSLSKPGILQSKPDLKTFDFEHFLSKPEQLTLNMEDDEETKPILGWIPRAGVAKPQTDLLELKNAFSKTGAQKRFHKSVLEDYKDLRDKEHLGKKHQFYGHNSYYFYN