lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Forms the central cylindrical rigid tube, which is surrounded by the outer contractile sheath assembled from gp18 subunits. The tail tube first 2 annuli are formed by gp48 and gp54, which are in continuation of the spike complex. During infection, contraction of the sheath drives the central tube through the host outer membrane, creating a channel for DNA ejection from the capsid into the host cell.
Subcellular Localization:
Virion.
Sequence:
MFVDDVTRAFESGDFARPNLFQVEISYLGQNFTFQCKATALPAGIVEKIPVGFMNRKINVAGDRTFDDWTVTVMNDEAHDARQKFVDWQSIAAGQGNEITGGKPAEYKKSAIVRQYARDAKTVTKEIEIKGLWPTNVGELQLDWDSNNEIQTFEVTLALDYWE
The following text describes a protein:
Function:
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.
Sequence:
MMESCLGEESVQMWELNRRLEAYLSRVKSLEEQNERLRLEIGNLREQPGEPSWRSQAEEELGALRALLDQRWSEKHAAEVARDNLLEEVEGVASRCQQQLLARERAKEQVAESRRVLEAEKWAGVCLGNQAAELEKELEALVAAHEQERAGMSAQVARSALGLETFRRAPDNAPAPDVQDLARTFGDAWRGAVEGYQARVACMEASLGQARERLGQAMQGTREGQREAQRLDVERAALQGRREMLEQRLEGQWQEQQEAGEKFQLAVEALEQEKQDLHNQIAQVLEDRQQLTHLKMSLSLEVATYRTLLEAESSRLNTSNIDSKATIIFPDPKMELCIPVTPEIRHPGPWPPVLSPTSLPMVDTPRTPMPAFLKSQGFLPTQTPTLASTPIPAISQAHHPGTGREVQGQDKKIVLATDSSIDPLAAKDGEEKDGELNDISSPQPPAPEPSKYQEKVGKEIQGVAEEDETKETIAENLEEKTWQKGGALDKEEIQERPGTSDEKVQETFGILSGKIRETLNLPGEEVQKTQKLPSEEFQEMQILPGEEIQETQRLPDEKIQETHIFPGEEIQKSKELPTEEFQEIQILPGKEVQETQKLPNEEFQEIQILPDELIQETQKLPDEEIQDTHIFPGEEIQKSKKLPTEEFQDIQILLGEEIQETQKLPSEEGQETQILPDEEIQETQILPDEEIQETQSLPSEKIQETLILPGEEIQGIQNLQTDENQEILSFPGEDKQEIMMPLEKETQETLRSLEDNEETLNSPKEGNLEIGENQETIGFPGEKKQETLSPLEEGVLEKKENQETLGSPKENNQEIVSSPEEGDLERENNQEIQGPPEENNEEIPKPQKGDLEREEEKSGSLKEEIQGILCFSEEGNQERGEMQEIPTLPEKEIQESLTSLDEGNLETEENQEIPEEGKGALERKENQEILQSLEVESLDLQKPEDVAGIGQDCSIEGDEKAPWETGKDHEETAKRKPEEQSSLEGNWEVVEEAGLRYGGSGESQHAGEEELGSQESEQQRFPTKETIKEGITTSPQVEFREVESTEFEALNCVPKMSEQMFEEDGSSRESDGEAPEDNGSITGLEPLEGEEVRNQEQLKKEVSESENWEGGLSEPHHREVILEPSLEQSDRETEKDVQETNELNQQYSKLLMENETPHPHLETPEVLEKPEQKNSLGMGEDSRHPSDLLPAETTIANNVDGGTTTQSSFMGQGGPQEIKQEVDISEDPLESHFRAEGNKELWESWETEGKTEVSEELVKEIGKVNAKDSSTVFQRNSSDSTSLGLYSREPDSPSWGMIAKEHPSPQEEHNDEPWDPPPRHTEVSRAQPDEGEDEDGAPDSDVSEEFEDLAVDASLLPGGPGRLMETVGPGSELVLDPPTWDRDRESDGFADEEEREPEEDRERNAHAPSDAGRREGAENFPPAILEVEKETKPLDRPKSLDSDIQSDSEEEHSHVTEDPEDSGPNEEELETPLPSNQSLFGVSDPTLLDKEDQASDSDLIEIPCRVDDSARKAGTSLNGGGPTMDQPDDIRGDILNGLGKLQEADQGKLWDLEREGGEGKAPGEELSSQTLWSGGPLILGQSPFLKFTQTKEEDRDSWSSGDE
The following text describes a protein:
Function:
Component of the abscisic acid (ABA) signaling pathway that may act as ABA signal transducer in the context of abiotic stresses. Triggers MPK7 activation in a MKK3-dependent manner. Mediates the ABA-dependent activation of the MKK3-MPK7 module.
Subcellular Localization:
Nucleus.
Sequence:
MEWTRGRILGRGSTATVYAAAGHNSDEILAVKSSEVHRSEFLQREAKILSSLSSPYVIGYRGSETKRESNGVVMYNLLMEYAPYGTLTDAAAKDGGRVDETRVVKYTRDILKGLEYIHSKGIVHCDVKGSNVVISEKGEAKIADFGCAKRVDPVFESPVMGTPAFMAPEVARGEKQGKESDIWAVGCTMIEMVTGSPPWTKADSREDPVSVLYRVGYSSETPELPCLLAEEAKDFLEKCLKREANERWTATQLLNHPFLTTKPDIEPVLVPGLISNSPTSVTDQTFWRSVEEEEEEETEEIQKDSRDLDRLSLWGCYSERIGRLKCVGGLDGTRCDMEGGDWIMVRARCEGTMISGSQKELIISENVLVGEL
The following text describes a protein:
Function:
Required for both chromosome condensation and segregation during mitosis and meiosis and X-chromosome dosage compensation depending on its binding partners. Regulatory subunit of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). The condensin I complex function is required for proper chromosome segregation in mitosis and meiosis. As a member of the condensin I complex, further controls the crossover number and distribution in meiosis by restricting double strand break formation, possibly by influencing higher-order chromosome structure. Plays a role in robust cytokinesis upon presence of chromatin obstructions. Also a member of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription during interphase, possibly through chromatin reorganization.
Subcellular Localization:
Nucleus. Chromosome. Note=During mitosis, localizes to condensed chromosomes in both sexes. In interphase cells, diffusely distributed in nuclei of hermaphrodite embryos prior to the onset of dosage compensation. Localizes to the X chromosome after the 40-cell stage when dosage compensation is initiated in hermaphrodite (XX) but not in male (X0) embryos, where it remains diffusely nuclear.
Sequence:
MPRKQRVVTTPSPPTSDEDEDMDFGSTSQQQQQQPTRNNDGLSGFKSITEIIAEADNNIPSEQIDKDIDSFSSYSDISDWRGIPKFFPSLSSLSRRASTYENWENRFKVVDYLVSCSGALKDSVSDYVADYFEKNESGEDHSVDVELVHAVSMFVILTQRLTVQLQLYVSKSIASANQQAKRGTGRGGRQVDLDDDIVKWKDIQRHRMINCLLELLELRVDTVAGTKKKAIQYVFAPDVMEKDFLLRFLDTVVQLLEDPENMARSSQQWISHYFRILKVLSADYGMTKDVANCLFTALSHSYLEAANTFPFIEPLVTLMKENGEGSGRIYQPLRNVLQLVICRVGNLYAGERAEKPPPKAFCMMVQSLAINVHDLMLQDITHVYRLLQNQHVNVRMSTLHALADMFSSSYLSQSLCDTFASRRLKREGIFKRLLAHTNDEATNVRSKAVSLLRNIMENRRIPEEFESCGLLSIVGSRLNDKSVQVRKSAIQFLTTFLDNNRHGHDFNREMHQLKLNAKCSELRNAEEPQSKAIQGAENAFRQNLFTLTAGVRVEVYDIFRRRYRVEPERSITDILTGLFSPGSGNRLVRYYVAQENFPFRDRIPSLRERRSDDMEDDDDDTVSLEDDDMTSLVSEVVKWVVAQAEEDYVTFKVQLTQMDDDQLLENEQEARDRNNQIMQLRAQVQQLINKMSIEQELSRCVTIALRCVLNGETAEIKEGIRFLTRCKLFEITGADDAIRSMCSLVWRPSADILNELIEAAEDMFISRLDGNEKASERDSSTVENLMKAMNGVTEKDRPSVEEVIYLLAATELVHVDSDKNKVPRKRRPIEANVINKLWMIALDMSHGINSRKIDALRILYPISRSERGIAEARSRLRVVQKKLMDPELAVDALRIISILGTPTKLENEQDAYSRPLFKIHQDDSLWKSIEKLFFYEIMKADDNPDRDWFGVIRLTITTILSLSMDVNVMLPKLASHFVYRTKRISDFFLFYCDQVDDATDDTRKKMAQRRREYWALTYCRVMEKLMAFIGEVAVQLNAYIQVTIPKLHTRYVSKMVDAEKNDANIREEPVRFLSDLEKSVAQRKTIFTVPQDTTPGATSNDLHHLVSVMCDKRLFVPNKLMGRLLPIVVYGMRCKIMPTRIRHAATVAYGKMMPLSAEISAFAAPSFFSAMTKSSSILLRCNLVAACCDFAFAQPTLFELFAQSLFRMSQDESPLARESTILVLSHLMSNDMIQTRGVLSEAARCICDPTRAVRDVAQSFFKELNSRTDTIIQLLPEFLYHLSNGNERMSFKSYKTVFEFLIQLLKDKPKASADSMIDRVCIKFSNTDMNDSETPKYLLVALAKFVQNDGGLHRLQDNWRHWSKFMCHPSVAKEYRMMVEHMHSTSKNDEFKSQCVELIDNINKIESEGLRKEDVAIGSSITKNKGRAKKNPTTMSGSSRTTSRAANSRRRAPPPAQSDEDDSDSDDAPAAPRSAARRKAKKSAVADDDSDSDEFMLDD
The following text describes a protein:
Function:
Involved in the production of glycogen and alpha-glucan via the TreS-Pep2 branch involved in the biosynthesis of maltose-1-phosphate (M1P), and probably in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Is specific for the glucosyl acceptor (Glc-6-P cannot be replaced by either mannose-6-P, fructose-6-P or glucosamine-6-P), but any of the glucose sugar nucleotides can be used as glucosyl donors. It is more active with the purine sugar nucleotides than with the pyrimidine sugar nucleotides.
Sequence:
MAPSGGQEAQICDSETFGDSDFVVVANRLPVDLERLPDGSTTWKRSPGGLVTALEPVLRRRRGAWVGWPGVNDDGAEPDLHVLDGPIIQDELELHPVRLSTTDIAQYYEGFSNATLWPLYHDVIVKPLYHREWWDRYVDVNQRFAEAASRAAAHGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQMPWRTEIIQGLLGADLVGFHLPGGAQNFLILSRRLVGTDTSRGTVGVRSRFGAAVLGSRTIRVGAFPISVDSGALDHAARDRNIRRRAREIRTELGNPRKILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVVVQLATPSRERVESYQTLRNDIERQVGHINGEYGEVGHPVVHYLHRPAPRDELIAFFVASDVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLEGVKDGIEEALNQTEEAGRRRMRSLRRQVLAHDVDRWAQSFLDALAGAHPRGQG
The following text describes a protein:
Function:
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKKKVDNRIKILIENNIAVGQRSMFFVVGDEGKNVVVNFYFLLNRLINRTHNILWCYKKKLDFSTSKKKRYREMKKKIKKGTFDQTIDNNFDMFLKNADIRFCFYKESKKVLGKTYSICILQDFSYITPNILCRCLETVIGGGLIIFLINKQNELKDLYNLTLNYHKKYTMNGICNVYNNYIHRFFLSLNKCENAMFIDDEMNILPLNENYLKIKKITSKGSDGNGIGNNVTKLKHMEVQKEGEQSGSNINNNDDDDNDDNDNYSNSNNYSNSNSNNYSHTKSATLGGFLCPDKNLLQEKLKFLESICEENEKKKEEEKIFLYSSKFSRNDTCTKINKNGDIHSSDNKYTRDTYETYDSVTNTSTTANTYNNYISKKTKKKDVYSFLDRNIMNLLNICLSLDQLEVLLNMCKILRNDEEKKKNIKEVLFNLLANRGRGKSATLGLLLSLSIYFNYSNIIICSGNNEGVQTIYDFLDKGLHILGFNEFKDYEKIYDMGKIKEIVIFKNMKYLKQRIRFFDIIEEDILNSELMIIDEAACIPIDILKKKIKGEITILSTTLNGYEGTGKTFTFKLLKQLKKKFITQLSYEEFKNMNFLYFDKAYIDLTLTNPIRYSYNDQVEKWLNDFLCLNCNEPTNIKDNICSPSNCELYFVNKNIFKNYNRTSEILLKKIMTLFITSHYKNTPNDIIMILDSQQHHLFILINKNNNHYNNNNILEDQIDELDIYGVLHCAIDGIINNGNVKKTVKLEDIIHLVKNNNTQKENPTLDTKEINDSNDQKLEKKENINQINSDNHKELLINEYEGNLIPYIISDYFNYYFYNYIGIRIVRISIHPSMQNLNYGSEFLKKVCNYYNEYNSKQRHDNNTKQKIKINNNDSNNCGDSNNCGDSNNCDDSNNCDDNVKYSENIILFNCNGKNIYFDKKLKQIDYIGTCFGLTKGLLIFWQKNKFIPVFLKQQKNEITGEFSVLMLKDLNEDLKHIIANFYTDFVRSVTKLLPYSFKYMESFIVFNLLHNNNYSIPLKQDDAPTIVKDHNNTDHTYNHNGHIKNNLHNNHFYYDNYEDQHLSFYNNNLINQQTIFYFFHTNDICRLKRFVLEGRNFYEILYLLSTIANLILFKKVKIDLSFLEYTILYAVAFQKKTPKEISDEIKINVNQTNAIFRKIIHRFYNYIKDIMEKQIEKEVNAELNEKLKVKKKRSLNIELPSEEYKDELERNSLIVKKKLKKEKLSLMKEFNLEGDIKRKEINIKTNDNLEIKKKKKKKKKKKKQETN
The following text describes a protein:
Function:
Required for pollen tube (PT) growth and integrity by affecting the stability of the pollen-specific ANX1 and ANX2 proteins. Involved in protein N-glycosylation in the endoplasmic reticulum (ER), especially in the female gametophyte. Mediates PT reception in synergids through protein glycosylation.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MGKRGRACVVVLGDLGRSPRMQYHALSLARQASFQVDIVAYGGSIPHEAVLNHPSIHIHTMAQPRFIQYFPKILYPVTLLLKAFIQFTMLLWFLFVKVPAPDIFLVQNPPSVPTLIAVKWASSWRRAAFVVDWHNFGYTLLALSLGRNNLLVSLYRWSENHYGKMATGSLCVTKAMQHELDQNWGVRAKVLYDQPPEFFRPALLEERHELFCRVRKDLCHPIGVYDFISRELENQELNETLFTTKFNADISLKQNRPALVVSSTSWTPDENFGILLEAAVMYDRRVAARSKGSETAEISEEQHHYPNLLFIITGKGPEKEMYEEKIKRLNLRHVAFRTMWLAAEDYPLLLGSADLGVCLHTSSSGLDLPMKVVDMFGCGLPVCSVSYSCIQELVKDGKNGLLFSSSSELADQLLILFKGFPGNCDALMSLKAGAMETGSSGRWATEWEDCAKPLITQVVSQIADS
The following text describes a protein:
Function:
Cell-wall hydrolase involved in septum cleavage during cell division. Can also act as powerful autolysin in the presence of murein synthesis inhibitors.
Subcellular Localization:
Periplasm. Note=Distributed throughout the periplasm in all cells.
Sequence:
MSTFKPLKTLTSRRQVLKAGLAALTLSGMSQAIAKDELLKTSNGHSKPKAKKSGGKRVVVLDPGHGGIDTGAIGRNGSKEKHVVLAIAKNVRSILRNHGIDARLTRSGDTFIPLYDRVEIAHKHGADLFMSIHADGFTNPKAAGASVFALSNRGASSAMAKYLSERENRADEVAGKKATDKDHLLQQVLFDLVQTDTIKNSLTLGSHILKKIKPVHKLHSRNTEQAAFVVLKSPSVPSVLVETSFITNPEEERLLGTAAFRQKIATAIAEGVISYFHWFDNQKAHSKKR
The following text describes a protein:
Function:
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1.
Subcellular Localization:
Cell projection, ruffle. Cytoplasm, cell cortex. Postsynapse.
Sequence:
MAAAGPAGPESRVLGYTLHRWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQSITFGKYEKTHVCNLKKFKVFGGMNEENMTDLLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELNGIDDPDVVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTRIALEHPMLTDLHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWGQIIPKSSKGDGEDSRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKESGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFDCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKENPGKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKEYLLRHCKYLIRKHRFEEKAQTDPLSALKYLQNDLYVTVDHSDPEETKELLASALFKSGSDFTTLGFSDVDHTYAQRTQLFDTLVNFFPDNMTPPKGNLVDLITL
The following text describes a protein:
Function:
Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MTALFGRYGIIKYEPLLAGIAGGVVSTTILHPLDTIRTRLAVSGSPLIAAGIRRPSYGGLVDVLTTITRSHGVQGVYRGITLGVLAAGCTWGSYFFFYDARKAQMHRDDPTRASLGAVNHMMAATESGLITLFLTNPIYVIKTRLCLQFGAQDFSEEKRYSGIIDALVKTYRNDGIKGFYKGLLPGFFGVSHTAIQLMMYEEMKSTYKEHYNMSLDSRMSTMTYLSFTALSKLIAVITTYPYRLMRTRMQDQHHEHNGLIDMVTRTWRYEGIRGFYKGMLPTLLRVTPATAITFVVYENVSHYFIENSVASKNKTQ
The following text describes a protein:
Function:
Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane.
Sequence:
MPNLLKDLFKYGKTDLSSKARRQTVAYRLLHVPKRWFTHFYLVGLLWCIFLCWDTCVFCHHGSDASWVVKHLYFLSAPGDPWMDDITSLAVTLGMFFIQVLRRLLECLFMSNMTGNIHVLHYVAGILFYILVGLSLVLPYFISPQGKCLVPPYSLQHPKWFHLPSLVLFTWSSFHQFKCHHIFYKLRDDSQLTSIHKVPYGDWFTFVSSPHYLAEILIYMSFIMVHGGRNPYTWLMLGFVVQNLCLGATANHHWYKAKFKSYPKSRYRIFPFLY
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability (By similarity).
Sequence:
MRGLEESGPRPTATPCGCVKPALETGNLLTEPVGYLESCFSAKNGTPRQPSICSYSRACLRIRKRIFNNPEHSLMGLEQFSHVWILFVFHKNGHLSCKAKVQPPRLNGAKTGVFSTRSPHRPNAIGLTLAKLEKVEGGAIYLSGIDMIHGTPVLDIKPYIAEYDSPQNVMEPLADFNLQNNQHTPNTVSQSDSKTDSCDQRQLSGCDEPQPHHSTKRKPKCPEDRTSEENYLTHSDTARIQQAFPMHREIAVDFGLESRRDQSSSVAEEQIGPYCPEKSFSEKGTDKKLERVEGAAVLQGSRAETQPMAPHCPAGRADGAPRSVVPAWVTEAPVATLEVRFTPHAEMDLGQLSSQDVGQASFKYFQSAEEAKRAIEAVLSADPRSVYRRKLCQDRLFYFTVDIAHVTCWFGDGFAEVLRIKPASEPVHMTGPVGSLVSLGS
The following text describes a protein:
Function:
Involved in both red and blue light signaling.
Subcellular Localization:
Nucleus.
Sequence:
MDSNSWINCPPVFSSSPSSRRYQSRSDLYLGDVEGEDDLKAEFMCPFCADEFDIVGLCCHIDVNHPVEAKNGVCPVCTKKVGLDIVGHITTQHGNVFKVQRRRRLRKGGYSSTYLTLKKELREANLQSLGGSSTFIPSSNIDSDPLLSSFMFKPPSAIPITEGDSVAQVSPKDTSKSKIQQESFSNEDQEKAKKSKFVRGLLWSTMLEDKF
The following text describes a protein:
Function:
O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol-10 into ubiquinol-10.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MWRGCKLSSSGSRFLGGLRSVYRGTRADCPRLTTSAVCSKNQLSWTLQIKPWVVNEYRIMWFKSCSMNFAFLNRMKSYRLPWIRPYSTSRSTVDSNEVKTFLALAHRWWDEQGVYAPLHSMNDLRVPFIRDNLLKTVANHQPGKPLSGMKILDVGCGGGLLTEPLGRLGASVIGIDPVDENIKTAQHHKSFDPVLDKRIEYRACSLEEIVEETAETFDAVVASEVVEHVIDLETFIQCCCQVLKPGGSLFITTINKTQLSYALGIVFAEQIAGIVPKGTHTWEKFVSPEKLESILESNGLSVQTVTGMLYNPFSGYWHWSENTSLNYAAYAVKSSVQEHSGPEFALKGEREELRAEASTNSGLRWDHGRAGLRSLVEENPLLDRGSFAGRSCVSAPRTPGH
The following text describes a protein:
Function:
[Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: The first exon of TMIGD3 isoform 1 (i1) is shared with the first exon of ADORA3 isoform 2 (A3AR i2, commonly known as A3AR), resulting in a fusion protein.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEGSPAGPIEQKEARWESSWEEQPDWTLGCLSPESQFRIPGLPGCILSFQLKVCFLPVMWLFILLSLALISDAMVMDEKVKRSFVLDTASAICNYNAHYKNHPKYWCRGYFRDYCNIIAFSPNSTNHVALRDTGNQLIVTMSCLTKEDTGWYWCGIQRDFARDDMDFTELIVTDDKGTLANDFWSGKDLSGNKTRSCKAPKVVRKADRSRTSILIICILITGLGIISVISHLTKRRRSQRNRRVGNTLKPFSRVLTPKEMAPTEQM
The following text describes a protein:
Function:
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
Subcellular Localization:
Cytoplasm.
Sequence:
MRILLTNDDGVHAPGLAALRQQLRHLGEVITVAPATEQSGVGHSITYLTPLVPKSIHRDGVHWAWAVEGSPADCVKLSLAELFVDEPIDLVVSGINNGLNAGINVLYSGTVAAAIEGAFFGVTSVAVSLENSDDNDFDAAAVIARNVIGEIVRHEESRGGLFNLNVPTAATESASEVKVVPMGLAQYGRRYEKRQDPGGRDYYWALWTQPDKPPAEMTDVTQLREGCVTLTPLHFNLTRDDLLSEMKDWNLRP
The following text describes a protein:
Function:
Probable b-type cytochrome.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSHDPQPLGGKIISKPVMIFGPLIVICMLLIVKRLVFGLGSVSDLNGGFPWGVWIAFDLLIGTGFACGGWALAWAVYVFNRGQYHPLVRPALLASLFGYSLGGLSITIDVGRYWNLPYFYIPGHFNVNSVLFETAVCMTIYIGVMALEFAPALFERLGWKVSLQRLNKVMFFIIALGALLPTMHQSSMGSLMISAGYKVHPLWQSYEMLPLFSLLTAFIMGFSIVIFEGSLVQAGLRGNGPDEKSLFVKLTNTISVLLAIFIVLRFGELIYRDKLSLAFAGDFYSVMFWIEVLLMLFPLVVLRVAKLRNDSRMLFLSALSALLGCATWRLTYSLVAFNPGGGYAYFPTWEELLISIGFVAIEICAYIVLIRLLPILPPLKQNDHNRHEASKA
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MGSSPPPPSFLVPTTRNEQELSFPGSLKLNDKVSNDGEEPGVSMYVRLFDEMIKTVLDGESYLFTQREIWVLNYILDLPYEPRYLLTRLLLRRPSRVHTYTSLVASYSSEIGEEGIKMAMKTLTRRLAVPKDIVNSDPDPVPGTPIASSSRPGPSPLSAKAEGRRPANALWANKPWVDSPSGLTEAQERADPELAAALKESYWASKVGRVNVDSDDEGDGLPAANNRSELVSTSVSTPTVSRQSSGIPTISPIEFSLTPESPPPVSFLAEDEKSLSLDDLMTCMSFDQLRKVAKAHKLSASSLLTRESTLNALRGMAKQQTVLGFAPMKGKGKATTPAQVHGKQTTLPFASKPKQTSELLLTAQMLSSFGGSAIRLTPSLHSLISRVNLIFSRTPPIAPGTASLMLPSILVTSNKRRYPDYGLTTRSKIWKDRDELLVWERAVGWEATVTEALGETWDQTRKNPNAAPIPGSTSRTGWVNRKEGAKIVRKIWEGTWDVWKEMVDGDKGKEVDVSKEEGGLVGDRFQTGHVLTRIVYKGAEALGILHEYDNECMVLRALLAQRRWRRGKRGAWYDRLALVLMNHYNSSPAEKEEKQREATQVCIDGLLDEATHLIYRPALSRRLKRLENKLNLPSDERHISFASLLTCKTRELNAVRSPENRGVVRAKSCSGSVAREGDDDEGTGGKGKLVGKSLWMGKEGEVSVEQWVLEWWEKKGYKGYHSESSILTTLFTLLIWPVLFHPLPGAFETSYQTAPLDLGEDTFAPSRRTLLEDRLAEISKTKRALELLREVDNRERPKGTWAVGVDWGYEKEDLEEILECLSGKALSGVCRMLAEEYRHRASGVPDLIVWNPQTKDARFVEVKGPGDSLSETQKIWIDVLLSSGIQVEVCRVKALSPTAAQLQSLEKKRKTSPALNISSNSIDVKRLKRRSTTSTISAYVKTDDGEYVKADEVVELDEEDDGWERRDEMRFESGVERREGRLE
The following text describes a protein:
Function:
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1, C4 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
Subcellular Localization:
Secreted.
Sequence:
MKMSDQQVQSPGSVKACHLGSCDLPITSTLGKVGAGETEGGVLLHFPVNNISGLGHAVFWTPLASSKMEHQEVVFLLLLFLKSGHGDILDDYVTTQGASLFTFTRKPLSASSIEECEAKCTEETAFICRAFQYHSKEPRCVLLAENRKSSPVMRMRDVILFEKRIYLSECKTGTGRSYRGTTSKTKNGVSCQKWSDTSPHIPKYSPDKNPSEGLEENYCRNPDNDEKGPWCYTTDPGTRFDYCDIPECEDECMHCSGENYEGKISKTISGLECQPWASQSPHAHGYIPSKFPNKNLRMNYCRNPDGEPRPWCFTMDPDKRWEFCDIPRCSTPPPSSGPTYQCLKGRGENYRGRVSVTQSGLTCQRWSEQTPHKHNRTPDNFPCKNLDENYCRNPDGETAPWCYTTSSETRWEYCNIPSCTSSSVPTEITDASEPPEQTPVVQDCYQDKGESYRGTSSITVTGKKCQSWSSMTPHWHQKTPEKYPNADLTMNYCRNPDGDKGPWCYTTDPSVRWEFCNLRRCSETQQSFSNSSPTDTQVPSVQEPSEPDCMLGIGKGYQGKKATTVTGTRCQAWAAQEPHRHSIFTPEANPWANLEKNYCRNPDGDVNGPWCYTMNPQKLFDYCDVPQCESSPFDCGKPKVEPKKCSGRIVGGCVAIAHSWPWQISLRTRFGRHFCGGTLISPEWVLTAAHCLERSSRPSTYKVVLGTHHELRLAAGAQQIDVSKLFLEPSRADIALLKLSSPAIITQNVIPACLPPADYVVANWAECFVTGWGETQDSSNAGVLKEAQLPVIENKVCNRYEYLNGRVKSTELCAGHLVGGVDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSSFINWIERIMQSN
The following text describes a protein:
Function:
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Subcellular Localization:
Cell membrane. Late endosome.
Sequence:
MGSLEQGERSWRQVDRTFRVEIFGQENEPQLCSVLCTGFLGVSWRWVQWRGPRTRCPRSPTPAAACGGSLPALPCLGQLGPQKSVRELSARAGTPRGAGWARPTWSLSRPATPDLPRAAHPTGSAGRQHNAPFARLLAGLRAGGRARETPPGPRLGAGGRREPGYGLLAMSSACDASDHYPLHLLVWKNDYRQLEKELQGQNVEAVDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENRQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLQKILEAPDFYVQMKWEFTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKGEDNWAELMEVNHDDKVVTTEHFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNIAFESGFYLNLIFVLMFMDPQHSVPDHGAWSFWRTKSGFWGWRTDKAEVVNGYEAKVYTVNNVNVITKIRTEHLTEEEKKRYKADRNPLESLLGTVEHQFGAQGDLTTECATANNPTAITPDEYFNEEFDLKDRDIGRPKELTIRTQKFKAMLWMCEEFPLSLVEQVIPIIDLMARTSAHFARLRDFIKLEFPPGFPVKIEIPLFHVLNARITFGNVNGCSTAEESVSQNVEGTQADSASHITNFEVDQSVFEIPESYYVQDNGRNVHLQDEDYEIMQFAIQQSLLESSRSQELSGPASNGGISQTNTYDAQYERAIQESLLTSTEGLCPSALSETSRFDNDLQLAMELSAKELEERELRLQEEEAELQQVLQLSLTDK
The following text describes a protein:
Function:
Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MMDEQRKAEYESQSLQLRAELKQFEAEWAQKNDGKKPSREAIKQNPDIAQKYKQYNKLRDILSGKIPPPTKSNNQDPSQRKRKQPETSLPSASTPSKRNRSAATPKSQHYSAVHEAITPDVARKLFSPAVPSSIGPTPQKDGRVLGLFDLISHTPSKSTDETKPRASGFTATPSNRRHALDLENDKDDDDHDEKDGKEFITPSIPRHRNLDRTPSSGRNRNLLDSFLGVRATKTSTPLNKNTGNSPSKNNLTKTPSGERSVSKLQFATPAFLRRTSAPLPPVDENGEWLDIEPLKLPRKPFSIAKGKGLSSVVASLRKMEEEKLDEELDMLREMEAMEQGGMGPPPPKQTVASTSEDTEKKKQVTDPAGAEVVPEEENSFEEDEAALIEVEASFLESPSSKRKKERRPVLLSGFDDENFYDSQDEEDLSKEGLDRNGQPLRVFKKKGQKRTTRKVNMRPTRTKRPSAPIAEEEDDGEEEHNDVIPETQFDATKNLDGDDHHTLDSLSSGGSGSEFDDGSEGEDEEAETSTTKAAKAAAKKKAPSAKEKTKKDATTETKKKKGTKEGGDEEPAKKPRMVKATANANFKRLKLKNNGAKGGPAHNSRFRRRR
The following text describes a protein:
Function:
Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (By similarity). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to U7 snRNA (By similarity). Binds to the downstream cleavage product (DCP) of histone pre-mRNA.
Subcellular Localization:
Nucleus.
Sequence:
MALSHSVKERTISENSLIILLQGLQGQITTVDLRDESVARGRIDNVDAFMNIRLANVTYTDRWGHQVELDDLFVTGRNVRYVHIPDGVDITATIEQQLQIIHRVRNFGGKGQGRREFPSKRP
The following text describes a protein:
Function:
Opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. Produces mainly (S)-betalamic acid. Required for the coloration of flowers.
Miscellaneous:
MISCELLANEOUS: Requires ascorbic acid for iron to be in the proper redox state. For the same enzyme from B.vulgaris (AC Q70FG7), presence of Fe(2+) is not necessary to detect activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MKGTYYINHGDPLMYLKKHIKLRQFLEGWQENVVIEKPKSILIISAHWDTNVPTVNFVEHCDTIHDFDDYPDPLYQIQYRAPGAPNLAKKVEELLKESGMECEIDTKRGLDHAAWFPLMFMYPEANIPICELSVQPSKDGIHHYNVGKALSPLLQQGVLIIGSGGTVHPSDDTPHCPNGVAPWAIEFDNWLEDALLSGRYEDVNNFKKLAPNWEISHPGQEHLYPLHVALGAAGKNPKTQLIHRSWAANGVFGYSTYNFTPTTQKTD