lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Subcellular Localization:
Cell junction. Cell membrane, sarcolemma, T-tubule. Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region.
Sequence:
MADFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGLAASQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPRELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYILSPFHPIRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNDTNGSVEADGLVWESLDLYLNDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVTTCERRSKRRKRMSSGTEECGDDRFPKSDSEDGPRAMNRLSISHGLSRTSMKQRSSRGSIFTFRRRDLGSETDFADDENSTAGDSESHRTSLLVPWPLRRPSALGQPSPGTSAPSHALNGKRNSTVDCNGVVSLLGAGDPEATSPGSRLLRPIMLERPPDTTTPSEEPGRPQMLSPQAPCADGFEEPGERQRALSAVSVLTSVLEELEESHRKCPPCWTRFAQRYLIWECCPLWMSIKQRVKFMVMDPFADLTITLCIVINTLFMALEHYNMTTEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRYRISDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDGEMNNLQLALARIQRGLRFVKRTTWDFCCGLLQQRPQKPAALATRDQLPSCIATSGSPQPPETEKAPPARKETRFEEGNRPGQGTPGDPEPVCVPIAMAESDTDDQEEEEENSLGTEEESSKQQESHPVSGGQEALPEPRAWSQVSETTSSEAYEASAAPAERRQQRQAEPPAPGCSETQEDSYSEGSTADMTNTADLMEQIPDLGEDVKDPEDCFTEGCVRRCPCCTVDTTQGPGKVWWQLRKTCYRIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLISLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSDCESFNVTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGFEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFLFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECIIKMTALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPSCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSALSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSATIIQRAFRRHLLQRSMKHASFLFRQQAGSSGLSEEDAPEQEGLIAYMMNENFSRRHGPPSSSSISSTSFPPSYDSVTRATSDNLQARVSDYSRSEDLADFPPSPDRDRESIV
The following text describes a protein:
Function:
Involved in the development of the embryonic central nervous system, embryonic mesoderm and adult musculature.
Subcellular Localization:
Nucleus.
Sequence:
MLSCLAPSSSRFGQEDTIIQQSMPSTSPFAMQFPSLASTLLHHNQSPKHSNPGSSGIQDAHPNQPGAAADAFLVKCTQCHKRFPEYQSLSEHIASEHPHDKLNCGAAQPESDAEDEQSNMSGSSRRYAKSPLASNNNSSTANANNNSTSSQSMNNNSELAKNHNSANKMSPMCSPGSLTPGDLFAQLQHPPPQLPPHLHAQFMAAAASLAMQSARTASSPSQQQQQQLQQQQQLQQQQQHQMAMQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTASFASREQLEQHEQLHSPCGPAAVSNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPGSASSASRRSPSDHGKGKLPEQPSLPGLPHPMSYFASDAQVQGGSAAPAPFPPFHPNYMNAALLAFPHNFMAAAAGLDPRVHPYSIQRLLQLSAAGQQQREEEREEQQKQQQHDEEETPDEPKLVMDIEEPETKEMAPTPEATEAATPIKREESREASPDPESYRSSSQAIKQEQEPLNVAEERQTPVEEHAPVEHAADLRCSRCSKQFNHPTELVQHEKVLCGLIKEELEQHFQQQQATSFALASASEEDEEDEEMDVEEEPRQESGERKVRVRTAINEEQQQQLKQHYSLNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSFQNNQAAGAAPPMPIDSQASLTREDQPLDLSVKRDPLTPKSESSPPYIAPPSGEALNPEAINLSRKFSTSASMSPASISPSSAAALYFGAAPPPSPPNSQLDSTPRSGQAFPGLPPYMLPMSLPMEALFKMRPGGDFASNHALMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHEDEFGAGVLMPPKPRRGKAETHGHAGDPDLPYVCDQCDKAFAKQSSLARHKYEHSGQRPYQCIECPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE
The following text describes a protein:
Function:
Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MEQGRPRSSLSLTSSASTVSSLSSLSAKKPTRVVHKVHAFGKRNNALRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYSVRPDGPGAPRGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGKASRAEGEDCGLPRSPARPRPGEGPGGPGGPPEVNRREEGRTSESPEVAPLSRGPGRHEMHAPGSSADLQPDTWSRRTRSPEPFSPLSRPPSPLSLPRPRSAPVRRPPLSAGDISFPARPHTPLSRIDVRPPLDWGPQRQTLSRPPIPRRGPFSEAGGGRPPRSPQLRTPEHRTQSTQVSSGSSTYLQLPPRPPGTQASMILLPGPPVDSTLHQSLETDTLLTKLCGQDRLLRQLQEDLDKRQEEKEQLEAALELTRQQLGQATREAAASGKAWGRQRLLQDRLVNVRAALCHLTQERERVWDTYSGLEQDLGTLRETLEYLLHLGSPQDRASAQQQLWMVEDTLAGLGGPQKQPPHTEPKSPSPAPQREESSERESLSESLELSSPQSPEVDWGQPPGGDRALSSSQSGVGSPRVSRASSPECRQQSSPLLRTKAPLARPRMSAQEQLERMRRNQACGLSLPRPTSPRLLTLGRTLSPVPRQPDMEQRPIVGAAKWLRSSGSWSSPRHSTTYSPVSGGHRERVLSLSQALATEASQWHRLMTASPERNLDTRGDCLQPSPQPPSEELPQVTSSPTSHKANSATTGFSCQGSGRGLAPWEPRWDPGKAPPALAQEEGAWPLRVTLLQSSF
The following text describes a protein:
Function:
Phosphorelay protein that supplies phosphate to regA or accepts phosphate from regA; depending on the relative concentration of the phosphodonor proteins. In vitro, acts as a substrate for cheA (bacterial kinase). Plays a role in the development. ypd1 (yeast) can complement rdeA defect.
Subcellular Localization:
Cytoplasm.
Sequence:
MISDYEGPTPTKKFDQDILFDYSEGEKEFTFELLDSYISSVEEHLPELLNSFEAKDLKGAVLHSHDIKGSSSYIGCEAVRYVSGKIEAYCKNDELEKAESFYPELKKEVEEVFKILSDFKKNWDKNHGEGGSDDGGDDNESEPTENNNNDGSSVNNNDSSSGGGGKDIENKNTDENTGKNLNERSKSPVPLQTTLKPVTIETPKTASDKIATETPTSLANNTNSSSNNNSKNENGLNSKQPQTSSNSPTKIQTK
The following text describes a protein:
Function:
Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
Subcellular Localization:
Cytoplasm.
Domain:
ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site; The C-terminal coiled-coil domain is crucial for aminoacylation activity.
Sequence:
MIMKQEPTTYQPEEIEKKIYEICSHRGYFEIDGNEAIQEKNKRFCLMMPPPNVTGVLHIGHALTLSLQDILARYKRMDGYKTLYQPGLDHAGIATQNVVEKQLLSQGIKKEDLGREEFIKKVWEWKEKSGGAILEQMKRLGVSAAFSRTRFTMDKGLQRAVKLAFLKWYEKGLIIQDNYMVNWCTKDGALSDIEVEYEERKGALYYIRYYLENQKDYLVVATTRPETLFGDSALMVNPNDERYKHLVGQKAILPLIHRTIPIIADEHVEMEFGTGCVKVTPGHDFNDYEVGKRHHLETIKIFDEKGILNAHCGEFENLERLEARDKVVERLKENALLEKIEEHTHQVGHCYRCHNVVEPYVSKQWFVKPEIAQSSIEKIQQGLARFYPSNWINNYNAWMRELRPWCISRQLFWGHQIPVFTCENNHQFVSLDTPLSCPTCKSETLEQDKDVLDTWFSSGLWAFSTLGWGQEKSGLFNESDLKDFYPNTTLITGFDILFFWVARMLFCSESLLGELPFKDIYLHALVRDEKGEKMSKSKGNVIDPLEMIEKYGADSLRFTLANLCATGRDIKLSTTHLENNKNFANKLFNAASYLKLKQESFKDKERLNEYQTPLGRYAKSRLNSATKEARNALDNYRFNDATTLLYRFLWGEFCDWFIEFSKVENEAIDELGSVLKEALKLLHPFMPFISESLYHKLSNTELENTESIMVMPYPKDLAQDEKLEHEFEVIKDCIVSLRRLKIMLETPPIVLKEASVGLREAIENTERLQTYAQKLARLEKVSVISSKPLKSVSDVGEFCQTYANLENLDLSPLVARLKKQLEKLEKEKLKLNLHNENFVKNAPKSVLEKAKESLKTLLEKESKIKQELDLLEQP
The following text describes a protein:
Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.
Subcellular Localization:
Nucleus.
Sequence:
MKLKREYDELIKADAVKEIAKELGSRPLEVALPEKYIARHEEKFNMACEHILEKDPSLFPILKNNEFTLYLKETQVPNTLEDYFIRLASTILSQQISGQAAESIKARVVSLYGGAFPDYKILFEDFKDPAKCAEIAKCGLSKRKMIYLESLAVYFTEKYKDIEKLFGQKDNDEEVIESLVTNVKGIGPWSAKMFLISGLKRMDVFAPEDLGIARGFSKYLSDKPELEKELMRERKVVKKSKIKHKKYNWKIYDDDIMEKCSETFSPYRSVFMFILWRLASTNTDAMMKAEENFVKS
The following text describes a protein:
Function:
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLEGKEGSPFRNRGLPQGAEKSNPSKRHRDRLNAELDHLASLLPLPPDIVSKLDKLSVLRLSVSYLRVKSFFQAVQKCPRPPAASAQSPEDGLSGGSAVLEGRLLLESLDGFALVVSAEGMIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPLHSETEDAVLGRLLRAQEGGAGSPTDFSAFLTRCFVCRVRCLLDSTSGFLTMQFQGKLKFLFGQKRKAPSGTVLPPRLSLFCIVVPVLLPSVAEMKMKSAFLRVKHRVDVSASMDAKAKAAAGLCEPELHGKPNYLAGRSDGENISVLRTPTDAGRWARVPARASCLCLRNGPDLVSNPEGFAGDRGAEEHGRVPRGRREIHAYSCCFEAPGPTRHLSWMPGKHSQEGSTRVKLEPSKSDPFSMHAVSRTSCVPCPSLPGAIHSSVAAAFRNPPSCHPGSHSPSAYTSPTSRAFRDSDQGQLHPLPSCPFPQGSLDSGLPPSRGQRLAVAGYPIEDTKFRGGPMPLGAPCNPILSLDVPIKTESDSGSEDAADGYSVAPGQLWPGATGVAKRQRVTFPTRMHLKTEPDARHHLYAAHLGQSVLEAHPSGRAPLRAGRDLAPFPPTHCACLEHVHGPPEPDGPRHLCTQAQQPSSLPCDCQAPESTPIVKREPLDSPPWASHGQGRVPGMFPKSAMATLMPPKAPECAFLP
The following text describes a protein:
Function:
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTNIQAFMKNFLGASPEWYKLAIVVFLIINPIVFFFISPFIAGWLLVAEFIFTLAMALKCYPLQPGGLLAIEAIIIGMTNAKHVKAEIMANFEVILLLIFMVAGIFFMKQLLLYVFTKLLVKIRSKIALSIAFCFSAAFLSAFLDALTVVAVIISVAMGFYGVYHKVASGNNLIDAVDISDDRKIIEQQHEILEKFRAFLRSLMMHAGVGTALGGVMTVVGEPQNLIIAEQAKWNFMEFFLRMAPVTIPVFICGLLTCFLVEKFKLFGYGEKLPDEVWKILSDLDRTNSEKMSKQDKIKLGMQALIAIWLIVGLAFHLAAVGLIGLSIIIFATSFTGVTDEHTIGKAFQESLPFTALLVVFFSVVAVIIDQKLFSPIIHFVLSAEENTQLALFYLFNGLLSSISDNVFVATVYINEAKAALTNGVIAPHQFELLSVAINTGTNLPSVATPNGQAAFLFLLTSSISPLIRLSYGRMVYMALPYTIVLSIIGLLAIEFILPAATIWLASLGLILPI
The following text describes a protein:
Function:
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: May be due to a competing donor splice site.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Membrane, clathrin-coated pit. Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity).
Domain:
The NPF repeat domain is involved in EPS15 binding; The DPW repeat domain is involved in AP2A2 and clathrin binding; The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction with the AP-2 complex subunit AP2B1.
Sequence:
MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQPPSCGPEDDAQLQLALSLSREEHDKEERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL
The following text describes a protein:
Function:
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Probably constitutes the main polylactosamine synthase.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MSVGRRRVKLLGILMMANVFIYLIVEVSKNSSQDKNGKGGVIIPKEKFWKPPSTPRAYWNREQEKLNRWYNPILNRVANQTGELATSPNTSHLSYCEPDSTVMTAVTDFNNLPDRFKDFLLYLRCRNYSLLIDQPKKCAKKPFLLLAIKSLIPHFARRQAIRESWGRETNVGNQTVVRVFLLGKTPPEDNHPDLSDMLKFESDKHQDILMWNYRDTFFNLSLKEVLFLRWVSTSCPDAEFVFKGDDDVFVNTHHILNYLNSLSKSKAKDLFIGDVIHNAGPHRDKKLKYYIPEVFYTGVYPPYAGGGGFLYSGPLALRLYSATSRVHLYPIDDVYTGMCLQKLGLVPEKHKGFRTFDIEEKNKKNICSYIDLMLVHSRKPQEMIDIWSQLQSPNLKC
The following text describes a protein:
Function:
Mediates sodium- and chloride-dependent transport of taurine. Mediates transport of beta-alanine. Can also mediate transport of hypotaurine and gamma-aminobutyric acid (GABA) (By similarity); Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREPNRWAVEREGATPYNSRTVMNGALVKPTHIIVETMM
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MLPVKIVSFLCLVFLADATSGLEHQSPIALSFRGSVGTPGIVDTRYKSSSAIFENGGEKDHRELTVGFLGDAGQFNLLRKIYHIENVHFHMPSEHTINGKRYPMEIHVVHKNSEGNIAVIGLLYNVGPRADPFITQLERYLPTLASSPEESKAVFIRTINPGLLRIPADMFFRYNGSLTTPPYSENVVWNVYSQPRSLTTNQYFSVKAALKGENARALQPLNNRLVQLVQLVRSDYHGRSSF
The following text describes a protein:
Function:
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MFEEPEWAEEAPVVADLGSVALGLRPTAVSQIKGSNRRQLLATLRALEVASLPQQSPSLPGSDSEEEEEVVETKKKRPKKGLFAGASNEVEEKRKKKRHKRGPPSSDSKEEEVEREKCHKGALLGSDLAEEEKKKRKCQKQIPSNLAQPLDSVDQTGSKAWNSSATSDPTKPTCETPSSNPPHTLSRKQWRNRQKNKRRQKNKFRPSQPPEQAPASAEEAEVPSAPSPDNHGARAEALRARMAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDPEAFLLYHRGFQNQVKKWPLQPVDRIARDLRQRPASLVVADFGCGDCRLASSIRNPVHCFDLASLDPRVTVCDMAQVPLEDESIDVAVFCLSLMGTNIRDFLEEANRVLKARGLLKVAEVSSRFEDVRTFLGAVTKLGFKVISKDLTNSHFFLFDFEKTGPPRVGPTTQLSGLKLQPCLYKRR
The following text describes a protein:
Function:
Selectively catalyzes the oxidative deamination of acidic amino acids. Protects the organism from the toxicity of D-amino acids (By similarity). Enables the organism to utilize D-amino acids as a source of nutrients (By similarity).
Sequence:
MPPRIIILGAGIIGLSTAVELQQRHQHRSAEPRPSITIVSAELPSQPSEWTEDPRCRPSPDYASMWAGAHYRPIPGATPQLQREAQWAMDTFRRMRRIARDAPEAGVRMMPGIEYLEDSPKEYGRLRTGDRYAGEHDEFRVLDKAELPEGVAWGCRYQTYSLNAPHYSRWLLDRFLAGGGQIVHRKLERLEEAFTLFEDGSQPLVINCTGRNFDQDDKMRIIRGQTVLVRNQFDRTITRQNRDGSWIFLIPRPFAGTIIGGTKEPGDMEVKPRMETRLKLLENCVRAFPEFVDRLEDFDVVLDNVGRRPWRDGGLRLEEERIEDGKTVIHAYGAGGRGYELSWGIAKEVADLVLATERSKFECRVSENLK
The following text describes a protein:
Function:
Is probably involved in a pathway contributing to genomic integrity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MVAWKLSSLLLLSLGALNAFAAIDVEKVAEEPVTPNLNVKVSVSFPQSEIFGIKLVNGHATEARLSVSNNEPTPIGVSLVGGSLSVEQAGESRIIRNLTTQKYSIEVPAGAEETIPYSFTTDQHPQDLRLLLTAVLRDQKNSFYTVPVYNETVTIVEGATSFFDPQMYVSMRMPYSLSITLANAHNSIFLYLVVLSVFGGISYFVYNTWITTFFPQKKGRGKGGERAKKSSLGSKKVDPADQVAVVGADGPAVTSGAKAYDESWIPASHLQRPEAKRVRSGTPKTKPKA
The following text describes a protein:
Function:
Plays a role in RNA-mediated gene silencing by mediating endocytic uptake of double-stranded RNA (dsRNA) ingested from the environment into intestinal cells from the intestinal lumen. Selective for dsRNAs of at least 50 bp. Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P.aeruginosa.
Miscellaneous:
MISCELLANEOUS: The avoidance behavior is transgenerationally inherited, and thus progeny display this same aversion despite never having been exposed to this pathogenic bacteria.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Localizes to the apical membrane of intestinal cells and also to punctate cytoplasmic structures.
Domain:
The extracellular domain is necessary for the uptake of dsRNA.
Sequence:
MPRFVYFCFALIALLPISWTMDGILITDVEIHVDVCQISCKASNTASLLINDAPFTPMCNSAGDQIFFTYNGTAAISDLKNVTFILEVTTDTKNCTFTANYTGYFTPDPKSKPFQLGFASATLNRDMGKVTKTIMEDSGEMVEQDFSNSSAVPTPASTTPLPQSTVAHLTIAYVHLQYEETKTVVNKNGGAVAVAVIEGIALIAILAFLGYRTMVNHKLQNSTRTNGLYGYDNNNSSRITVPDAMRMSDIPPPRDPMYASPPTPLSQPTPARNTVMTTQELVVPTANSSAAQPSTTSNGQFNDPFATLESW
The following text describes a protein:
Function:
May play a role in BANF1 regulation and influence tissue-specific roles of BANF1.
Subcellular Localization:
Nucleus.
Sequence:
MAHRKDTGSLTPKTPMKSEVLTSGLTCNLQECQEVPWVMEEMESTSEKQSTFESQPMGEKDITEVDGITTTLGEHLVAKGFDKAYILLGQFLLLHKNERTFQDWIMTKCGASPDEAQQSCRCLKNWCHSFL
The following text describes a protein:
Function:
Transcription factor. Plays a role in resistance to amide-linked indole-3-acetic acid (IAA) conjugates such as IAA-Leu and IAA-Phe. May regulate gene expression in response to metal homeostasis changes.
Subcellular Localization:
Nucleus.
Sequence:
MVSPENANWICDLIDADYGSFTIQGPGFSWPVQQPIGVSSNSSAGVDGSAGNSEASKEPGSKKRGRCESSSATSSKACREKQRRDRLNDKFMELGAILEPGNPPKTDKAAILVDAVRMVTQLRGEAQKLKDSNSSLQDKIKELKTEKNELRDEKQRLKTEKEKLEQQLKAMNAPQPSFFPAPPMMPTAFASAQGQAPGNKMVPIISYPGVAMWQFMPPASVDTSQDHVLRPPVA
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MDGRRDVDDGGVAGAAAQERRWRGGGGDDEESSGLSNGGGGGGGVELSLRLRTGADDGAATAAALPPPPLPPPAEARRNMTIFYNGRVCAADVTEIQARAIISMASEETLADHRGRRRRQQQQLTRVDGGDGRQQDGDSSSSSTTTSAVALARRCARGRGLVGPAVDIDQAADAGLSMKRSLQLFLQKRKARTAAAAAPPYAGGRQAQAVRR
The following text describes a protein:
Function:
Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MREEDEEIEADGANYQLEMMRYKSTLLGSYQTVELIETFMNYQTGQILKLVLVATQSFTGRVQIDQSNKETDLLKNNNDLIYASVDKTPEGVSEALHPATEALLHDIPFVGKDSVVVQEISYNEIIAKGSLVQWTGLRYHGMSCGSKKERIGAGSFGTVYRAEWHGSPVASTINTLAGALYKVFCASPDPASIEMLRACFDYLSLGGVCSDGPIALLSGLNPRPLSLVLHFFAVAVYWFYPLYGNSDGSARFYNFS
The following text describes a protein:
Function:
Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSKKSLGLDVRLELEGLISNDDTIRSEKDGRQASIFRVAELDARTEADNLRSIIHQSAREGNVNALQEALLKAPLAVNAQDGDFMTPLHYAARYGNYDAVKLLLSKNALPNTKNREGDTPLHIASKYIYGYSDICSIIDEDQADSARKYNTATKKIINALVSENAEIDPVNKYQLTPLHYAAMKSNFSALHALIKLKADVDAEDDNKMTPLLLACVHGSQEIIQELIKANSNVTKRDQRLNTVFHIVALRGEPEYLEMMMDHDPVEAIKALNLFNNEKKTPLRMAVEGNHPETLKKILQMEKKNSCKWMDREKELIHFAAEKGFLEVLKALVEAGGNKNELNEVKAVPLHVAAQMNQLEVVSYLIEEEKDNIDVVDEQGLTPLMMAVTHDSKKCVEYLIAKKANLTITDKDERTPVFIGAKFNALSSVEYILDHLRKKNKETERSALKSPTRNTLRIVSEDVRRTMVNMVDRDQNTPMHIVASNGYLEMMQLLQKHGASITQVNEDEETALHRAAIGGQTGAVRQLLEWDIRLLLMKDEMGNSALHLAARSGHDATTKVLLDNGADKEAKNSYQKTPLQVAVDSGKLETCQRLVAKGAQIESSSDTKTVLHTAAFYGNESIVRYFIAEGVTIDRRDEEGKTAFDIACENDHKDVARAFLETDQWKNLMIPCDVIPLDKHRNPVNMKRRTPFRTLLTKFPELASFVMDNCIEKSKEETDSTQSVAYNFEFLDDTYMMRCVSDDGTGEQLIGCKSAYDEDFKLEKDAQSYASNYDRVYKYHPLKLMADAEKLHLLNHPLSKALLKYKWNRLGRPMYYFALFMYLVFIVSLTQYVRHTKAPYNVWNEESYYDSEYFDENETCPQINTTKPDVVWKIIIQTLAVCQILVECFQLFQRKFAYLVNWENWIDCFIYSTALITVYDFSECSATSGVRQNWQWILAALCIFFGWINLLFMIRKMPRFGIFVVMFVDIVKTFFRFFPVFVLFIIAFSSSFYVILQNRPEFSTIFMSPLKTTVMMIGEFEFTGIFHGDETTHAEKMFGPAHTAVACALFFFFCIIMTILLMNLLVGLAVDDIKGVQEKAELKRLAMQVDLVLQIEASLHFFIQRTKKYATCRYATFPYGKLHKTGFAGWWSNFRRRFGLSVSTDPEIDEMYEREAEFTSEMTQKLQNQAAKLKNIQENIDVMYEKQVRLEAIIAKLATGLNINIELEEKDN
The following text describes a protein:
Function:
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Sequence:
MPAPDIPKSVIQKLMFFTALMVVFPLLTFFILQYFTDNSIISGGVAALAANVVLISYIIVAFTEDTTKLDEKDESKKDI
The following text describes a protein:
Function:
Catalytic component of the Dbf4-dependent kinase (DDK) complex. Phosphorylates components of the pre-replication complex, including Mcm2 and, to a lesser extent, Mcm4. Phosphorylates histones, including H3 and H2B. Required for DNA replication and mitotic proliferation, including during the endoreplication and amplification stages of DNA replication in egg chamber follicle cells of the ovary.
Sequence:
MADRVMCQELATPGSHYRRPKTGVPSTNVVYANGGGSWRAAPRQTQRLPRQTVQQYATGTPATGSAGRHSGRAFATAGATEEQTVEFNGAAVMGLPATPRTTKQARNKSEEAINDLLTRIPDIGKLFDVHSRIGNGTFSTVLLGTLRRESHLPDSLRRKFAIKHHIPTSHPDRIMKELQCMTKMGGKENVVGIHCCMRYDASAAFVMPFMAHDRFQDFYTRMDVPEIRQYMRNLLVALRHVHKFDVIHRDVKPSNFLYNRRRREFLLVDFGLAQHVNPPAARSSGSAAAIAAANNKNNNNNNNNNSKRPRERESKGDVQQIALDAGLGGAVKRMRLHEESNKMPLKPVNDIAPSDAPEQSVDGSNHVQPQLVQQEQQQLQPQQQQQQQQQQQQSQQQQQPQQQSQQQHPQRQPQLAQMDQTASTPSGSKYNTNRNVSAAAANNAKCVCFANPSVCLNCLMKKEVHASRAGTPGYRPPEVLLKYPDQTTAVDVWAAGVIFLSIMSTVYPFFKAPNDFIALAEIVTIFGDQAIRKTALALDRMITLSQRSRPLNLRKLCLRFRYRSVFSDAKLLKSYESVDGSCEVCRNCDQYFFNCLCEDSDYLTEPLDAYECFPPSAYDLLDRLLEINPHKRITAEEALKHPFFTAAEEAEQTEQDQLANGTPRKMRRQRYQSHRTVAASQEQVKQQVALDLQQAAINKL
The following text describes a protein:
Function:
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAIHPDKIQVATGQVGKDPYICVWDTYAMVTVSILRDVHTHGVACLTFDSDGQRLASVGLDAKNTICVWDWRRGRVLATATGHSDRIFDVCWDPLQSSRLVSCGVKHIKLQFWTLCGNALTPKRGIFGKTGDLQTILCVSAAKDELTYSGALNGDVYVWKGVALVRTIQAAHGAGIFSMHACEEGFATGGRDGCIRLWDVDFKPITKIDLRETEQGYKLSIRSVCWKADRILAGTQDSEIFEVLVRDRDKPVLLMQSHSEGELWALALHPKQPVAVTGSDDRSVLWSLPDHTLLARCNMEESVRSVCFNSDGSQLALGMKDGSFTVLRSEGYADSNSGESDSDVSDIPELDSDIEQESQTNYERQVYKEDLPQLRKKLIGSLKRQKAPEEGLRLQFVHRYRGFDCRNNLYYSQTGEVVYHVAAVGVVYNRLQHSQRFYLGHDDDILSLTVHPLKDYVASAQVGRDPGIHVWDTQTLNCLSLLRGQHNRGVCALEFTDGKSLISVGIDESHSIVIWDWKKGERLSKAGHKDKIFVVKSNPFRMDKLVTVGIKHIKFWQHSGGLTFRRGIFGNLGRQETMMSACYGRSEDLLFSGATNGDVYIWRDTTLIKTIKAHDGPVFAMCSLDKGFVTGGKDGVVELWDDMFERCLKTYAIKRATLSPSSKLLLEDNPSIRAITLGHGHILLGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPVCATVSDDKTLRIWELSSNHRMVAVRKLKRGRCCAFSPDGKALAVGLNDGSFLVVNADTLEDMVTFHHRRELISDIRFSQVGKYLAVASNDSFVDIYNVLTSKRVGVCKATASCITHIDWDSRKLLLVNTGAKELLFFEAPRGRRQNISLTEFEKLDWSTWTSVLGPTCEGIWPALSFVNAASLSKDRKLLATGDDFGFLKLFSFPSRQGQFAKFKKYVGHSTNVTNVRWSNDDSVLLSVGGGDTALMIWSREPPGHKESKAVDSEESDDDTEEDGYDSDVAREKAVDYVTKIYSSSIRNMSGTKPHLQHKELPVEDPPVSRATPLPDKLLRNNVTKKKKVLEQDLVLDHVFGYRGFDCRNNLHYLNDGTDIIFHTAATAVIQNLSSTQTFYLEHTDDILCLTVNQHPKYQNVVATGQILAPSIHVWDAVTKQTLSILRCSHAKGVGYVNFSATGKLLLSVGVEPEHTITVWRWQETKASSKGGHTERIFVVEFRPDSDTQFVSVGVKHIKFWTLVGGSLMYKKGVIGSVEDSRVQTMLSVAFGANNLTFSGAINGDVYVWREHFLVRVVAKAHSGPIFTMYTTLRDGLIVTGGKERRTKEGGAVKLWDQEMKRCRAFQLETGQPVENVRSVCRGKIQGKILVGTKDGEIIEVGEKNAASNTMINGHTHGGIWGLASHPFKDVFISAGDDGTIRIWDLVDKQKLLNKVSLGHPAKCTSYSPNGEMVSIGMETGEFIVLLVNSLTIWGKKRDRNVSIQDIRFSPDNRFLAVGSVESAVDFYDLSLGPSLNRIGYCKDISGTVIQMDFSADSRHIQVSTSTYTRQVHEVPSGKVVTEQNAINRITWASWTILGDEVLGVWPRNADKADVNCVCVSHAGLNLASGDDFGLIKLFEFPCPEKFAKHKRYFGHSAHVTNVRFSCDDKFLISAGGSDC
The following text describes a protein:
Function:
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Sequence:
MSGVVNKFFITSLVMWAAPVAILYAFNHNFVPGVTDMSPHSMTLLSGFVAVISVNVVIAFYICLAMREPSDKHEPDPKFLAEAKASVKQLGQNQDGGSSETRSKQE