lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombination (By similarity).
Subcellular Localization:
Nucleus. Note=Localizes to nuclear DNA repair foci in response to DNA double strand breaks.
Sequence:
MTSNQSISTTELLQFLTDIETNIDDHETDFRKLLLYLLRFTNEKLIVIAQEENKTPTELQLLSKLIDTIELVLSKKTPLLSTLLTIEDVNIIHTTGSGSLVYEVPLHEWCISFALSHIPNFVSHTAGLNQLKRLVFLIVNLVSTQLHSFKVIKSTRIHLLKTLDDNLNFCLQNLLSANTFLFKSKLTTAVNLFSIVHDYDISQKLSLNLNNYQLKFESCSRKIWFILNEISLVSELDNLNLLDCLKSVFILDQSSALVLNVSVGWNQIGFLLSCIVEYLQQDFRTLDSNTNNFEFVNLNRSISLSLLNVYIVCFDKDLLENFMSFSNIKGILSKLIYDDSIPSVIRKTLNIVQYTYQLMSNPDGDDIKLYSTSVYNDYVWTPFVDSELESLRARLLDLQGNHEDSRKEELLSFSIDETHKLAKSTNSLNYTDEKAWIRTVKKLIGIDKNVLEDETTLYTLVTALSHYPCILKGDYDYTINECTKCGFGPLTKNNYSSIDPNRFPLNYSTEATTLQDIIQQFLIPKLETQQDPLLCCNTLLLIFNFYASFSPMADMQDHNILDFLLRLLATNDNRDVRMLVARILPLYLIQSKDDKLLDETFKYIFQKVTSIDFSSQHRLHFGESTIRAVVELATVSTGERLCAIYFKLVDWLGEQNEQHSNYVYCGILNLASAKSLPPHKLLSPYLPSVAEIIIKKPQVFERIIKVSMVTKNYFLNRTKEYTVPRILEYYKDPTLLTQIANAAGLEVGKLLANCLPRILATYLTKESVNERYIMKVLSSVCPDYKMIHTEELFTRIGDITWYILLEIQMDEFGNIRNLANITRALECVCKNVSLRKNGSELTKNNSINDLIEDQVLLLVQKFSDVTHSSRGAKPYLELKNSFYAIEFLIKGHIDAITSALGQLSTCLQATLEEPNFHVLSLRCWNELIKKVPPSHLISLIDIIISIILQKFESFGSEAKSIAIEILRKIYEEIKDKYNRYSLYFLSLPFLSYMEDYQMVKEFRNMKSPSRAMIFSEFTRRLQTSNMYVVKHALFDLSNYFEKYQINCQKDLFKDPGLTPAITSLVRTILDTAAKFKNKDTTVSTACAKALAIIGALDSNKFQFKTVKSLIIISSDFEDIEENSTFLVDLIENHLLKIFWASNDPHKQLFAAYVMQSFLAVMGLDERVLNTKDNRVWNKFTDVAKSTLTPFLKSKYAAPKPKLDNLKFPFFKLGMKYETWLVDVTLFLLKRASIDNGKGNQKAKTRKLIFQSYAVLIQREHDIPLCEHLLRYVALSHVINEGVPEDLHKEFLHILKMDSKSTSPDRAEQLKLCYQTIFSVLDYFNQWVSNMRVVTSNSGSELTSSDIRHKMDAVAKFSSFPQDLLTTRSAECDAYERTIMYLENCYRDSQSEKSFKLSNLNGAATLQDMYAHIDDYDALNGTLKMFSTNNLNEKLTTFQYSDSWSLAHESFEALGSTKNSVSNNTKLLQSLNEHGLYNEVLSTLSARTDSNDLKSIPLDWSLMGLHAAVYKGDSKQLEKWLQVINSIGKPHDMETMINYELAKALSFLFQSRIDMFKGSMDKLYNIIGCSLVPSVSSNFTRNITLMNQLHAIYDVSLIVLSKDSEDTLDLRIGNVDQDFDTQRNILTLHNVANTVMKNPAMISKNLLRESSLARKYNRLDISTRSIVQAMSLEDDQANIEFAELQWAQGKQSEAIKCLFDILKDNKFHDDKSKAKVQLQYANWLDESNHLSAHQIITEYNKAFHLNMVDEKCNFDIGKYYNKLMESSNDESGEYEHLTVRNYIRAVSVGTTYIFEALPKVLTIWLDFADKSNKSNAAENRLKQIIDDLYNAIANVPNYSWYTVLTQILSRIVHEHEPSFKVLKRIVQNVTLEYPKHCVWYIFSHARSSDKVRKRRVRELLNQVCTQDGNDTLPKSTMAAGNLFAKLIKIAELKIPKTNRKRQMSLLQDFEVDLSEPIDDLVIPIQSNLQIQIPSHLNSKHKGFSRSSSISFDGFDDNVNIFFSLQMPRQLTVRGSDGNAYRLMVKSDDTRKDAKVVEFTTMVNRILSTSTEARKRGLQIANYSVVPLSDHFGIIEFVMNVQTMKGVISEQRKRQGIPINERKVFMHIDSLQKAKKKDSKQLDKLVAGFRAIMDRCPPVLHTWFVEQFSDPSAWYMARNAFTRSSAVMSMVGYIMGLGDRHCENILIFKNTGAVLHIDFDCLFEKGTTLPTPEIVPFRLTQNMVDAMGITGVDGIYRITCEVTGTLLRENEQILMNILETLIYDPLIDWRNHNPREDLSKVRKKIRGLINEDEGLPMNIHGQVDVLIQEATSLERLSQMYAGWAAYM
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKLHQVLQPAIITLQILGLNFGKLSKIKILHTITSLIMCLAVTFYYWKNRKVGFGFVLSKVVFLAAVTRSLGTIVVMIMVLALNYSGYFDKIVHLTQKIDNFDNEFEDIVSLNQKHKKMILVLLVIVNLGLNGLIDWYTVCLVPLNPYQFFLAVQYPRIVVSTFNIVFYMYTLILEERFKLINLIIKQEEFFSPKIKRMVLLHKTLVRVAKSLNQVFAPQLLLWVLLGVMVVTVDLHVFFFTLFNKLLGQYPVGIVGVKNASLFIFDLIFLSFRCTKLCKEANKTAFLWYHIKIDREDEEARDDFIKLGIKLSNDKLEITACRLFKIDNSLILDMFGSVTSYLFIMLQFDEIIT
The following text describes a protein:
Function:
Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs. Essential for progression through meiosis. Involved in spermatogenesis.
Sequence:
MNKSKLLCPEHSQPHLILLLISYHFHLPRAVSLPILARIEIAMTSKHNFKLHDDNFWTNAFRLCDELRSETEDTTDDEEDEVKEAPPPSVARPRLCLKRASKRDEWHDEDHSDVPPDHWDDGRDTDSHASSWDLQRTASTPGGGDSADDEDVRSEIWSDSSQSLANSHHPMLSNQHIPVIDDKYMEYYEFLADGFDKLVQEVESHRPALPSWMLAVGDLERGGDRIGRFPPRPQRRANDRYPMASFECGEKAGLGCPALKPKLYHQHNPGPEVFSRKVFVGGLPVDVDEDELLTTFSPFGHLCIDWPNKQMNGMPGTLDRTFPPKGYVFLIFQYELSVRKLVEACTCEEEKLFFAISSPMSPQKLVQIRPWKLADADYIVDVNMPINPRRVIFVGGVPRPIRAVELAHIMDKLYGSVVCAGIDTDLEYKYPKGAGRVAFTNEASFIRAITDRYAQLSHGEQRVRVEMKPYVLDDQPCDECDGMAARHAPFFCPHLECLQYYCESCWTELHACPTREHHKPLSCWTELHACPTREHHKPLVKEA
The following text describes a protein:
Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Subcellular Localization:
Secreted.
Sequence:
MLTGTSSLSSFACALMLWALFSPPSVQACQGDELPCDMVLGWLKRRILEGLGLDEPPLPVLQLPTRQAGNRAVHHVASRMTRETRVERRHHQESSQVILFPSSESTCKDIPGHSSDAGPGHFTYYFQPSLDSQESIITSAHFWFYAGETIASINISAPLFILTHNKELLKASESPVKRSPDGWTTYKLDVHLHTPMADGQFMLQIRCPTCSCHDSEDKTPFLHLHTRSSGPDRSRRAPKIPWSPDAIENLKRPASQGTDCRREQIEISFEDLGWNNWIVHPKSFTFYYCHGNCSSAERITTILGITQCCAPVPESMKSLRFTTTSDGGYSFKYETLPNIIPEECNCI
The following text describes a protein:
Function:
DNA-dependent transcriptional repressor.
Subcellular Localization:
Nucleus.
Sequence:
MAVESRAVSTPVPQNSQEQELILVKVEESRSWGQKLKQSGSARSCQELFRQQFRKFCYQETPGPREALGRLQELCYQWLRPELHTKEQILELLVLEQFLSILPEELQIWVQQHSPKNGEEAVTLLEDLEREFDDPGQQVPATPQGPPMPWKDLTCLGAAQEFTHIQRQPLKKQLKPWEPCLPPKSGCENNESAIKKDISGEKSQRLSQEPSFGGFSEHKSSLEWQQGSAPGETLRRSPSQRASFSPVIFTHKLLANRDHPEPQRNLILSTNSVTYQKVPTEERPYRCDICGHSFKQHSSLTQHQRIHTGEKPYKCNQCGKAFSLRSYLIIHQRIHSGEKAYECSECGKAFNQSSALIRHRKIHTGEKACKCNECGKAFSQSSYLIIHQRIHTGEKPYECNECGKTFSQSSKLIRHQRIHTGERPYECNECGKAFRQSSELITHQRIHSGEKPYECNECGKAFSLSSNLIRHQRIHSGEEPYQCNECGKTFKRSSALVQHQRIHSGEEAYICSECGKAFRHRSVLTRHQRVHTVK
The following text describes a protein:
Function:
Effector that suppresses plant defense responses during the early stages of pathogen infection. Suppresses cell death induced by effectors and PAMPs in plant hosts. Interacts with host acetyltransferase TAP1 and causes TAP1 relocation into the nucleus where it acetylates histones H2A and H3 during early infection, thereby promoting susceptibility of host plant to P.sojae.
Subcellular Localization:
Secreted. Host nucleus.
Domain:
The RxLR-dEER motif acts to carry the protein into the host cell cytoplasm through binding to cell surface phosphatidylinositol-3-phosphate; Residues 69 to 86 are required for the interaction with host TAP1 and its re-localization into nuclear speckles; The nuclear localization signal (NLS) is required for localization into nucleus.
Sequence:
MRLTSILVLVIAATFHTTGTALTLTKDSKAGIANGDSPASGDFIDANSARLLRRVEKDKVDYEQDEQRSFGALKDAVKKLNPVTAVKKFFKQRAKRKKVIQTARDADNNLAWAMKEVYKAAN
The following text describes a protein:
Function:
Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLTYIGERVVRGPDWEYNDDDGGDGCVGTVIAIKEERSGHSRSNETARTNWKVQKVTVAWDLGHIGDYRTGLDGKYDLACMDVGLGRPHLLIECDVCSRYPVRYRWLCAVCKSFDLCDACYNKNEHHLDHQFVRFSSPIGSCVRAPTRESSLNNRVEARGLFVGAEVSKDGKQGIVVETLRYELQWGGVKVLWPWEGGEVTRHTLEDGVIDIKCEEAAKYGLYYKDHLANFGERTLCLGDMASVLVDVDEIKQLQEEHGDWMPQMTDSLRQVATIIAVTYNGDCKLHFPVLDLGWDFNTEAVTRVGY
The following text describes a protein:
Function:
Forms an efflux pump with AaeB.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MSTFSLKIIRVGITVLVVVLAVIAIFNVWAFYTESPWTRDAKFTADVVAIAPDVSGLLTEVPVKDNQLVQKGQILFVIDQPRYQQALAEAEADVAYYQTLAAEKQRESSRRHRLGIQALSQEEIDQASNVLQTVQHQLAKAIAVRDLARLDLERTTVRAPAEGWVTNLNVHAGEFINRGATAVALVKKDTFYILAYLEETKLEGVKPGYRAEITPLGSNRILHGTVDSISAGVTNSSSSADSKGLATIDNNLEWVRLAQRVPVKIHLDSEDQQYLYPAGTTATVVITGPNDRDPHQASPMTKLMHRLREFG
The following text describes a protein:
Function:
Probable pheromone receptor. Shows high specificity for 4-hydroxyphenylacetic acid. Activation of the receptor stimulates intracellular calcium release.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDLCVTIKGVSFLLQAGLGILANALVLLAYAHIRLAEARLQPVDAILCHLALVDLLLLLTRGVPQTMTVFGMRNLLDDTGCKVVIYTYRIARALSVCITCMLSVFQAVTVAPAAGPLLSGVKARLPQLLAPTFAALWFINMAVCIAAPFFSVAPRNGTVPPFTLNLGFCHVDFHDNLSYVLNGVAVSVRDFAFVGAMLASSGFILLLLHRHRRQVRAVRRSQGSTMETRAARTVLMLVILYSVFFGIDNVIWIYMLTVAQVPPVVADMRVFFSSCYASLSPFLIISSNRKLKARMVCATSEQERQAEDGKNSSGKN
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MALRLLRLVPASASARGLAAGAQRVGRIHTSVHCKLRYGLLASILGDKTTKKLHEYSRVITVDGNICSGKNKLARDIAEQLGMKHYPEAGIQYSSSTTGDGRPLDIEFSGSCSLEKFYDNPKSNDGNSYRLQSWLYASRLLQYSDALEHLLSTGQGVVLERSIYSDFVFLEAMYNQGFIRKQCVDHYNEIKRLTLPEYLPPHAVIYIDVPVSEIQSRIQKKGDPHEMKVTSAYLQDIEDAYKKTFLPKMSEICEVLVYSSWEAEDSTKVVEDIEYLNYNKGPWLKQDDRTFHNLRMLVQDKREVLNYTTVPVYLPEITIGAHQGSRIYDSFRELPGRKYAPGYNADVGDKWIWLK
The following text describes a protein:
Function:
Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Required for mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking.
Subcellular Localization:
Preautophagosomal structure membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
Forms a homotrimer with a solvated central pore, which is connected laterally to the cytosol through the cavity within each protomer. Acts as a lipid scramblase that uses its central pore to function: the central pore opens laterally to accommodate lipid headgroups, thereby enabling lipid flipping and redistribution of lipids added to the outer leaflet of ATG9-containing vesicles, thereby enabling growth into autophagosomes.
Sequence:
MEQSEDTIQHERKNTFLSRVFGVHSSEVGDSIETAELSQYPIQIARSGSNAIDESRVIESDQASSSEEEDTDGHDLSVAENMTSYNGAQGSGSEDSDVPFSDQELETIETYTIAKVGQGSSSEDDRLQADSAEEEDALLFQHRLQDGSKGRNKVSSQPLGLKRILGSKGKSILGKEPASQEDSFIFRKGPTWDEENQLRPESKRPGLLSGKSNARLSSPSRPSPLSARERALWKWANVENLDGFLQDVYSYYLGNGFYCIMIEKILNLLTLLFIVFISTYMSHCIDYSKLPNGHKFSDVRVDQCYETQITGTTKLLFWIFGVFVVLKVVQMYFDFRRIHEIHNFYTYLLNISDKELQTIPWQSVIHQIMRLKDQNAVTANVVEVKAKNHIDAHDVANRIMRKENYLIALYNKDILHLSLPIPLYRTSTLTKTLEWNIHLCIIGFAFNEAGFLKQSFLNPAQREFLSEELKKRFILAGFLNIILAPFLVVYFVLLYFFRYFNEYKTSPGSLSTRQYTPIAEWKFREYNELYHLFKKRMGLSYEVANTYINQFPNALGDYFFKFVKFISGSFVAILALMTVLDPENFLNFELTADRTVLFYMTVLGTIWAVCHSAVNDNCSVFDPEDSLKELITYIHYAPKEWDGRYHTDEVKQEFCKLYNLRVILLLRELASLIMTPFILWFSLPNSAESIVDFFREVTVYGDGLGYVCKYAMFDENCKKGLRTNKHLQGTQTKYGHSLGDDHDSSDEETDKGMNKMIQSYMYFVDDYQNSVNAVGKYQIPKTQNLSHESKYNMKSHQHYSWKKQFKLGSKPEDFKIGSVTPRALSSSILANKPKSNLRARLDPEISHSNVQFDDLGESFINSIPVADYDPIERSDAMGGNGVLGLLNQYYRKSDVGR
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MAAAMTFCRLLNRCGEAARSLPLGARCFGVRVSPTGEKVTHTGQVYDDKDYRRIRFVGRQKEVNENFAIDLIAEQPVSEVETRVIACDGGGGALGHPKVYINLDKETKTGTCGYCGLQFRQHHR
The following text describes a protein:
Function:
Cell autonomous antagonist of both the canonical and non-canonical Wnt signaling pathways.
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MGKLHSKHACKRRENPEGDSFVVNGFIAKRAAEEGERYGNNLKDYKNEELKDSQPTLLHCPLQVVLPPEKAEGCESFLQYLSPDDEERDAQKVTKRISLQDLECNVSLAEDNRQEWVFTLYDFDNSGKVTKEDMSSLMHTIYDVVDASVKHSCNSKRRSLRVKLSVTPEPAARRRDATHTERETSHLSQVEPVRSEEHRSADRRQSTHIRGQTEAHEGNHYCVDENTERRNHYLDLAGIENYTSRFDSSSPDADQDPPSRSSHSQSRPHSQEPETHVYQRRSQLMEPCVAPDPRLRTGPQLIRSRSPKGSSRYPGVIPNVTKTSKCHGHHQPISAGQDVYHLTQQSHTHAHTPSGLQHSHSRRIRSRAREQQALTPVKNTNATALVQRHEHHHHHEHHHHHHYHHYHQT
The following text describes a protein:
Function:
Plays an important role in meiotic recombination and associated DNA double-strand break repair.
Sequence:
MQSSLEESAVEYLDRSGALQKLIQDCRTRAEIESHQDKPSAVFRFVLTVDPMDLVNFDSTLGNLVLHYPLDAGRIFQDVVYLSIKALDLIPQVESRNQILVHLSIPTLPPLPSYSLHLRDLSCQAVEQRYFQFEGIVSSMTNVIQYTQSARYQCPESGCVGSEPYTYIRLHTAGASESRTIRPDFQCHHCGNILEEDVSCRVLADKRVLYWIPTIDRCRGDITISIEANSIVKQVVQPSPSVALPDSVTRLYQDRLGSPYSFAASLAFAFASSVSPPGTYHKLKLSMLLSLVSTQANNKMKETKDSGGLHVMAVGSDTLLLSRLLTYCAAMSSPCVHHTVDKHLFAKVTKDTHGTGTCSIDAGSLLLSHGGCCFLGDLGQVKRDVQSSLQGVMEKDVVTVQIPKKYGDSGVLQSLDLPIRCSIWAYTDPNSCRKPAATAGADLFLQQELGNVSKTLADCFSLVCYTDSTSETGDMYADSLLVEDILNCATLKEEDLENVGELLSAKDIKQFLQVACCLHPQLTPPAEYLLQGYFISSRRLRSNSIQSCPFPPTALRTLTSVACAHAKLSLRTYVAEEDALVSISLFEESVTSRYGYSILGVQPTPHFRHGNIVQYLGKENDTQMEQFHLQLLRLISSHAQDLTIRQPEE
The following text describes a protein:
Function:
Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+); Involved in cholate and Na(+) efflux activities, which may be mechanistically coupled. Does not require other Mrp proteins for its own function.
Miscellaneous:
MISCELLANEOUS: Mrp-dependent antiport apparently occurs by a secondary, proton motive force-dependent mechanism, but the similarity of several Mrp proteins to membrane-embedded subunits of energy-coupled NADH dehydrogenase complexes raises the possibility that there is a capacity for electron transport that could provide a primary energy coupling option for Mrp functions.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINLIAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR
The following text describes a protein:
Function:
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization (By similarity).
Sequence:
MEGINNFKTPNKSEKRKSVLCSTPCVNIPASPFMQKLGFGTGVSVYLMKRSPRGLSHSPWAVKKISLLCDDHYRTVYQKRLTDEAKILKNLNHPNIIGYRAFTEASDGSLCLAMEYGGEKSLNDLIEERNKDSGSPFPAAVILRVALHMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEALEENGIITDKADVFAFGLTLWEMMTLCIPHVNLPDDDVDEDATFDESDFDDEAYYAALGTRPSINMEELDDSYQKAIELFCVCTNEDPKDRPSAAHIVEALELDGQCCGLSSKH
The following text describes a protein:
Function:
Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Also mediates NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity.
Miscellaneous:
MISCELLANEOUS: IRAG1 gene is a common integration site of murine leukemia virus, leading to induce myeloid leukemia in BXH2 mice. Murine leukemia virus integration occurs at the 5' end of the gene between 2 differentially used promoters and thus probably alters the expression of an important gene for myeloid cell growth.
Subcellular Localization:
Membrane; Single-pass membrane protein. Cytoplasm, perinuclear region. Sarcoplasmic reticulum.
Sequence:
MGRSLTCPFGISPACGAQASWSIFGVGTAEVPGTHSHSNQAAAMPHIPEDEEPPGEPQAAQTQDSPSAGPFPSPPTIVLTGDASSPEGETDKNLVNRAPSPHRRLSHRHLKVSTASLTSVDPSGHVIDLVNDQLPDISISEEDKKKNLALLEEAKLVSERFLTRRGRKSRSSLGDSPSAVSPNLSSGASPASSRSCSLTISTSPGLDICSGPQSPLPGAPPQQKGHEDGVSSPCPGEPNVSKGLADLKQNDQRKVSQGRLAPRSPTVEKTKELTVEQKENFDPLQHVEATPMAQASGASISGKMALNSPQPGPAEMELGRQLLKTAREGNPLPRTTAQGSGGTVSPHSLGQGSAGEPMGPKAGSKAELRSPVSRPPLIRGVSWDSSPEEPGPLLQKVLAKLPLAEEEKRFPGKAKPAKPPGLKDFQIQVQPVRMQKLTKLREEHILMRNQNLVGFKLPELSEAAEQDKGVSPELAPAAEEEESKSGLDVMPNISDILLRKLRVHKSLTGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNLTEENTEKELENFKASITSSANIWYHCEHRETYQKLLEDIAVLHRLAARLSSRAEVVGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNSSRSCGPSEDGVPRTARSMSLTMGKNMPRRRVSVAVVPKFNALNLPGQAPSSSPMPSLPALSESSNGKSSISVSPALPALLENGKTNAEANCEVGAPVPLPSCLEETSQETKAKAEEEAYSKGYQEGVKKTEELQDLKEEEEEEQKTESPEEPEEVEETQEDEKDQGSSKLEELVHFLQVMYPKLCQHWQVIWMMAAVMLVLSVVLGLYSSYNSCTEEADGPPGRSTCSAAQRDSWWSSGLQQELPAEQ
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MCLALRKDSELSSCSSSRRNFGIWSPELRHPGGERRRLLGSCPDGREFSVAGAGAGAEAEALRPAFNAYGQVCLNSDGSSDCYADRISQVSQSTNLSQQNGLFNDYSRLCSGVVDNGFRVGGLVSRSSLNGRRAQFAQVLLNCTSIEAMRGRIESIATDPEGFRVLLSMMERMDRDEAELVFSETIERVGYLMTDPFANHVVQRLLEVCSEEQRKQILYAVTWNSQIVSICLSTYGIRSIQKLMDTLTTRWQKNVVIHALAPFMYQLIKNAIGHHVIRHCLKVFSNEDNEILYDLVATKCYEIATDKSGCCILQQCVEHAQGKQRDRLVTEITTHALLLAENCYGNYVVQHLLTLEIPQVADDLHRQFLGNYAILSCNKYGSNVVEKCLKEMGYNQFKQIVVELLEEFLTVLLNEYGNYVIRRAVEVSKEQRQTQIYYILSAELRRYDPLIKSNPYGKKAVSRLEKQNILP
The following text describes a protein:
Function:
Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis). Positively regulates the transcription of genes involved in vascular smooth muscle contraction.
Subcellular Localization:
Nucleus.
Sequence:
MTLLGSQHSLLIRSKFRSVLQLRLQQRRTQEQLANQGITPPLKSPTEFHEQRKHLDSDKAEDGLKHKVRNRPDRADVVNMHILQASTAERSIPTAQMKLKRARLADDLNEKIALRPGPLELVEKNILPVDSAVKEAIKGNQVSFSKSADAFAFEEDSSSDGLSPDQTRSEDPQGSAGSPADAKASETPLAGPLGAVQDHSSGSENDRKDSASQPSNQSDTGKQGLGPLGNPIAVHTAVKSKSLSDSKNRHKKPKDPKPKVKKLKYHQYIPPDQKAEKSPPPMDSAYARLLQQQQLFLQLQILSQQQQQHRLSYPGIHQAQLKEPNEQMVRNPNSASTPLSNTPLSPVKNNFSGQTGVSSLKPGPLPSNLDDLKVSELRQQLRIRGLPVSGTKTALMDRLRPFQDCSGNPVANFGDITTVTFPVTPSSSLPGYQSSPTTSALSNGFYHFGSTSSSPPISPASSDLSGAGSLPDTFNDASPSLCLHPSPVHACTEESLLSSLNGGPLAPELDGLDSEKDKMLVEKQKVINELTWKLQQEQRHVEELRLQLQKQKRSHCPEKPPPPPFLAVPIKQEDAVSSCPFAPQQRSGKRQGHGSEGQAQACEAAGRRPLGPAPCAEASSGPSDALPSTFLSPQCSPQHSPLGAVKSPQHISLPPSPNNHYFLPSSSGAQGEGHRISSPVSGQVCTAQNSGAHESHPASFSPQPSSLHPPFSGAQADSSHGAGGSSRPKSPGVQPKMAGLHSSSDKTGPKFSIPSPTFSKSTSAVPEITQPPSYEDAVKQQMTRSQQMDELLDVLIESGEMPADAREDHSCLQKVPKIAGSSRSPTAALAKPSSSGAQLSFDPYGADSDEHLEVLLNSQSPLGKVSDVALLKIGSEEPPFDGIVDGLSGKAAEELFSAHEILPGPLSPMQTQFSPSSVDSSGLQLSFTESPWETMEWLDLTPPSSTPSFSSLGTGGPSIFNIDFLDVTDLNLNSPMDLHLQQW
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity; The exact function of the theta subunit is unknown.
Sequence:
MLKNLAKLDQTEMDKVNVDLAAAGVAFKERYNMPVIAEAVEREQPEHLRSWFRERLIAHRLASVNLSRLPYEPKLK
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDVKTIDTIFQLGKFALLTPKSRSEKTPSLGRKIYAFILMVFLTVGALVNIVCKIPHYQTLGLMQMVLRVLSDFSLLLSTVFALVMVKTTTRGWYHLIRNLSQVCGSGTSRKTAFVAWFVSETLILICMQVAFMRKAAFRFIQTHFFQILQIFFIFFRAVTGITVLHMVKQCYHSQKEIIRKGFEALPSVEHNLLLLKEAVSCFNDIFGWNFFYFIIFGICRTLVLIDDNVKSPKGMITRVVYYNFSLEVLGGLVILVKFWTYALYFIMLADKVVKEFDDIFADFSEIFARTTNNKKYSLLNEIEQCRPKFSAARFYDINKSTVFSIISTVTTFVIIILQFELRVEF
The following text describes a protein:
Function:
Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.
Subcellular Localization:
Secreted.
Sequence:
MCVPEHLLDLCQQMSAQETKSSAKIICIPARDRFECIEKIKQRVADFGTVDPEDMYIAAKTPEQDFAVFEEIRTREEPEAEFRYEAVAVIHKDLDIKGIEGLKGLNSCHTGVGRNVGYKIPLTKLKQKGIIGPLNDPELSPRENELKAFSTLFSKACIVGKWSPDPKINLEWKKKYSNLCALCEKPETCDYPDNFSGYDGALRCLAHNGGQVAWTKVIYVRKFFGLPDGIKENPEKFAYLCPDGTKVPITGTPCRWAARPWQGYMANADVVKTVDELRRKIENLDSVGTKNHAPWLEKVLELNDKTVPKENKIISPGDYLDKANYTDVIERDYGPPFKTVRFCVTSHDEYLKCQALSQAAFSRDIRPRFGCVEEKTVESCMKSIRDNLADIISLDYGQVDKARREYNLVPIVAEQYGSLGGAYYAVAVVKKGSKFASFADLKGAKSCHTGLGRTAGYHAPLYTLIRLNLVPKNACPYPKALSEFFKASCLPGAREIKEGYAEHLCELCGGDIDKRDVTTKCNHDSSESYSGYTGAFRCLVEGGGDVAFVKHVTVPGNTDGHNRDKWAEHLKSGDYELLCPDGGRKPVDQYEQCHLAHAPPHMVVTSHSKRNSEIDEIRNLLISTSKQYTERPDLFKLFGSFNGKKDLLFKDSATGLKSVSQESEIEKEYSKVLALVNGCA
The following text describes a protein:
Function:
Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation. Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter. Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes. Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors.
Sequence:
MLRILGLVSLFCILFQAALASNSEENALDMSLVEDECSMMVCRAGRECKVGADGEAACACLATCPDHFVPVCGSNNQSYDNFCLMHRDACLTGVHISLKKKGYCSNKSIKKKSSKKDKLKDENHFEPVVCFQWERDALRRQIINYFRHHTADQSWYRPDLKSYEKQFARFFMCDTTKDNFVDANELAACVTEVPFALRTTAATNELVKVLCVDAIIDSADTNSDWRLDFEEYKTLMDSSFQPKEKLCSLEGKKYEDGSQTKVDCNDCVCACGSWVCSSKKCDEELNEIDDLDEDEDLDDELDEAEDQSEDNTKDEVKILKIEEDIDLKIDDPDEDQPPKINSDDDDDMDDEEDEEDDEEEDEEIDVEPIKKSSKNKKKKLT
The following text describes a protein:
Function:
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.
Sequence:
MGNSRSSALSRDVLQELQTSTTYSQEQLFSWYQKFLNECPTGRISREQFQSIYASFFPDADPGAYAQHVFRSFDADSDGTLDFKEYIVALHLTSSGKTVEKLEWAFALYDVDRNGSITKNEIHEIVKSIFNMISKEDQKNLPDDENTPEKRTDKIWDFFGKKENGKITEGEFIQGVMDNKHILRLIQFDKPQKVQEKLKEKTQ
The following text describes a protein:
Function:
Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.
Subcellular Localization:
Periplasm.
Sequence:
MRLLPLATALTLAVAMGVAPAQENRLPDIGSSAGELLTPARQAEYGKIMLAELRNYDYVLDDPLVTDWLQTMGTRLGANSDQPQQPFTFFMLRDRQINAFATLGGYIAVNAGLVLTAEREDEVAAVLSHEIAHVTQQHVLRGVERAQRDQIPILLGMLAAVVAAQQAGGNSSGDATMATITSAMGLMQQRQIDYTRSNESEADRLGIRTLVRSGYDVDAMAGFFERMSVAMRANEGGYSAPDFLQTHPVTTTRISEAKARAEQMKKNTVVLTTSVPGGTRQERVDPSDPSLSEPLSRNGNALLPYALRLPVDALSRSSDQQGFDWAKERLRVLSASTPDSAIREYENLRRSAKQGLTDAQRYGLALARLRNSGSRPAEPVAELTSLLEAHPDNLWLALGLSEAQARVGPREQANARFDALLKRLPNNRAVALTYAGALNEQASKEAGQRARQVLEPLLYRSGEDPLLQQTYARACELSGDQVRASEAYAESAYLNGRAEQALIQLEALKKKDLDYVTRARVDARIAAITPTVLELRRQGIRDPDLSQR