lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: Minor; MISCELLANEOUS: [Isoform 4]: Minor.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Note=Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region; [Isoform 1]: Endoplasmic reticulum. Nucleus membrane; [Isoform 2]: Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localizes to chromatin. Able to shuttle between the nucleus and the cytoplasm and to dephosphorylate plasma membrane receptors. Recruited by activated ITGA1 at the plasma membrane (By similarity).
Sequence:
MSATIEREFEELDAQCRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQSAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTRAVVMLNRTVEKESVKCAQYWPTDDREMVFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGEDVNVKQILLSMRKYRMGLIQTPDQLRFSYMAIIEGAKYTKGDSNIQKRWKELSKEDLSPVCRHSQNRTMTEKYNGKRIGSEDEKLTGLSSKVPDTVEESSESILRKRIREDRKATTAQKVQQMRQRLNETERKRKRWLYWQPILTKMGFVSVILVGALVGWTLLFQLNVLPRLTDT
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MDFTRKLSFLVFLLCILISLQNQDDIDTNNKFSSHDDKYCSLSDDESHYIFDVDSFPPLPMFATTSHVERKLQQQTGARESLKYDYYHQTCPQAERIIRSSVRDLFKKRPQIAPALLRLAFHDCFVEGCDASVLLDPAEGFHSEKESPPNESLKGFDVIDIIKSELEEACPGVVSCADTVVLAARESVILTGGPFYPLKTGRRDSVASFGEVATFELPSPQDDLSKMIVSFSSKGFDEREAVSLLGAHSTGVIHCKFFINRLYNFSGTNSSDPTMNSEFVSLLRSKCNTNQASLMSPASKAQSPSQLVSSSPSPSSIMDELASALVEEPAMKMDYEGPGANFGTLYYRSLLQGRGILYVDQQLTTGEETKTWVQAYASDVSLFHKDFGLVMMKLSNLGVLTAPMGQVRKDCRKVS
The following text describes a protein:
Function:
Regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sensitivity to cefoperazone and chloramphenicol. Represses the cecR-ybhGFSR operon and activates the rhlE operon. Acts by binding to a palindromic sequence within the intergenic spacer located between these two divergently transcribed operons.
Subcellular Localization:
Cytoplasm.
Sequence:
MNNPAMTIKGEQAKKQLIAAALAQFGEYGMNATTREIAAQAGQNIAAITYYFGSKEDLYLACAQWIADFIGEQFRPHAEEAERLFAQPQPDRAAIRELILRACRNMIKLLTQDDTVNLSKFISREQLSPTAAYHLVHEQVISPLHSHLTRLIAAWTGCDANDTRMILHTHALIGEILAFRLGKETILLRTGWTAFDEEKTELINQTVTCHIDLILQGLSQRSL
The following text describes a protein:
Function:
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNSAKVNPSGHAPTPAPTASQGAAFPANRYALFFGLAIAGGALDLWSKEAIFRWRGLPGTQDVYWIIEGYFGIETAVNIGAVFGLGAGQGLVFAAISVFAAAAIIAWLFFFKAARSCWLTFALGCITGGIIGNLYDRLGFWWKPGLPDQWQSGVRDWILWQASDQWKWPNFNIADSLLVTGAIMLLVQSFFFPPPPHGEADGNELPGRRAPDEPTEGTKPAAS
The following text describes a protein:
Function:
May have a photoreceptor function.
Sequence:
MHARLLPARARSLCSSAVGITVPSPGLRRASPALAPRLSASPTRRTLCVRVMATAGGGQRLVLWFRNDLRLHDNYIVHEAAQRVKRGEASEVLPVYVYDPRFFAATPWGALKTGAHRAKFIQECVADLRQRLQGLGSDLVVAVGQPEQLLPALLEGGGAAPLVLTAEEVTSEEAAVDVAVARAIKPAGGKLLRYWGHTMYHYDDLVQGPPAAGGKGIFAPGMKDLPDVFTPFKEKVEKRAAVRRDLPPPAKGELPLPPAPRLGATAAAALAAPLPGWEQLPWPAGARPAPPVTHPKAVLDFKGGETAALARLKYYLWDSDLLSTYFDTRNGMLGGDYSTKFAPWLAQGCISPRKIFHEIRKYESQRFSNKSTYWVIFELIWRDFFRFFALKHGNRIFFETGTSGLPLVWNPDPELWARWREGRTGLPLVDANMRELAATGFMSNRGRQNVASYLVLDLGVDWRRGADYFEEVLLDYDVTSNWGNWVAAAGLTGGRVNHFNIAKQSKDYDPTGEYVKTWCPELKNVPVTKVHEPWLMSKEEQERSGCRIGVDYPNPIPSSRHGRPHAGAGSGGDRFGNRPSSGRGGGRGGGGGGRGGRGGGGGRPRSEFDRYK
The following text describes a protein:
Function:
Iron transport multicopper ferroxidase required for Fe(2+) ion high affinity uptake. Required to oxidize Fe(2+) to Fe(3+), which is then transported into the cell via the ferric iron permease FTR1. Essential component of copper-dependent iron transport. Also has cuprous oxidase activity.
Miscellaneous:
MISCELLANEOUS: Present with 1050 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein; Extracellular side.
Sequence:
MTNALLSIAVLLFSMLSLAQAETHTFNWTTGWDYRNVDGLKSRPVITCNGQFPWPDITVNKGDRVQIYLTNGMNNTNTSMHFHGLFQNGTASMDGVPFLTQCPIAPGSTMLYNFTVDYNVGTYWYHSHTDGQYEDGMKGLFIIKDDSFPYDYDEELSLSLSEWYHDLVTDLTKSFMSVYNPTGAEPIPQNLIVNNTMNLTWEVQPDTTYLLRIVNVGGFVSQYFWIEDHEMTVVEIDGITTEKNVTDMLYITVAQRYTVLVHTKNDTDKNFAIMQKFDDTMLDVIPSDLQLNATSYMVYNKTAALPTQNYVDSIDNFLDDFYLQPYEKEAIYGEPDHVITVDVVMDNLKNGVNYAFFNNITYTAPKVPTLMTVLSSGDQANNSEIYGSNTHTFILEKDEIVEIVLNNQDTGTHPFHLHGHAFQTIQRDRTYDDALGEVPHSFDPDNHPAFPEYPMRRDTLYVRPQSNFVIRFKADNPGVWFFHCHIEWHLLQGLGLVLVEDPFGIQDAHSQQLSENHLEVCQSCSVATEGNAAANTLDLTDLTGENVQHAFIPTGFTKKGIIAMTFSCFAGILGIITIAIYGMMDMEDATEKVIRDLHVDPEVLLNEVDENEERQVNEDRHSTEKHQFLTKAKRFF
The following text describes a protein:
Function:
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Sequence:
MASPPPGAGLTEYERRREENIRRNETILAALRRKAAELSASFIPTASSPKRPKKQHPLARTTSPVVLRRSLRTRGIPAGESSACDGANTSLNTPPSPTKPRSTRFSSSLASALRDATAAEPSPSVKSWIGAPDGFDPCRELVLRPVDVRKVVPGRILSLRILPLSDRTVVVAGNVHGHIGFWDVDRLVEDEDGDGVDGVFEYFPHRGSVGGIVMHPAMLHKIYSSSYHGEICLMDVEKENFNTVYLCDYPIFSLCQAPNSPSSLYFAEGNELKLFDERMGKVPTTWSLHDHRINSIDFRPENPYIFATSSTDRTVCIWDIRRMKKKGSESLKVLEYNKSIQSAYFSPSGNMLATTSLDDTVRIFDIDNFDDSCTLKHDNRTGRWLSTFKAIWSWNDSNLFVGSMKRAIDVISVDRRQKSISASYMAFLESEHMTAIPCRFTLHPCKVGHLAGASSSGKVFLWTRA
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSPRGSQGVVGPARTRALSTSGRAAAQAPGSRRRLGPEPSGSRSPCTRFRLFSSLDRAACVLLRRSLPLLPRSDPAMPAPQCATCHKARAALRRPRSGRALCGACFCAAFEAEVLHTVVAGRLLPSGAVVAVGASGGKDSTVLAHVLQVLAPRLGISLRLVAVDEGIGGYRDAALAAVRRQAARWELPLTVVAYADLFGGWTMDAVARSTAGSGRSRACCTFCGVLRRRALEEGARLVGATHIVTGHNADDMAETVLMNFLRGDAARLARGGGLGSPGEGGALPRCRPLQLASQKEVVLYAHFRRLDYFSEECVYAPEAFRGHARHLLKLLEAARPSAVLDLVHSAERLALAPAARPPAPGACSRCGALASRALCQACALLDGLNRGRPRLAIGKGRRGLDEAGPPRDGEPERAPAPDAVPAF
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane.
Sequence:
MPNSDQNFIDSNSSCRGSYYTMSSKKASIVMLAAADASRFGESINIVFRWKRSLYKMIWRHSLVFLVVYFSLTALYNFGLEKDNKKHFEALSAYFARYTRSFNWMIMLGFFTNTALHRLFTMQMTTPGTAKTATIFIMSLKQDLPEGPDIVDQYARWVVLAWILTFRSVCKPLRDKFPNLTAIQTSGILLEEEKRILQRGGYPTPRPLIVIEWLLLLLKECVKEDRYINKSSHNKNVEAVMTFKKGCSNIIKFSTQNIPYAVIQAVIIVVYCFGVVTAMARNLPKFDNEIVRHVIGYFPVMPYIQFFVFIAWLSVGRAAVNPFGNDDTDIDVRKLCEAHMQDLNWLTELYTKKLDDVFYNLPQKQFRSNNQEQPSKLPFLETAC
The following text describes a protein:
Function:
Involved in elastic and collagen fibers formation. It is required for EFEMP2 deposition into the extracellular matrix, and collagen network assembly and cross-linking via protein-lysine 6-oxidase/LOX activity. May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved in the processes that regulate vessel assembly. Has cell adhesive capacity.
Miscellaneous:
MISCELLANEOUS: Its deposition precedes the appearance of elastin and is simultaneous with that of fibrillin 1.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Note=Found mainly at the interface between amorphous elastin and microfibrils.
Sequence:
MAPRTLWSCYLCCLLTAAAGAASYPPRGFSLYTGSSGALSPGGPQAQIAPRPASRHRNWCAYVVTRTVSCVLEDGVETYVKYQPCAWGQPQCPQSIMYRRFLRPRYRVAYKTVTDMEWRCCQGYGGDDCAESPAPALGPASSTPRPLARPARPNLSGSSAGSPLSGLGGEGPGESEKVQQLEEQVQSLTKELQGLRGVLQGLSGRLAEDVQRAVETAFNGRQQPADAAARPGVHETLNEIQHQLQLLDTRVSTHDQELGHLNNHHGGSSSSGGSRAPAPASAPPGPSEELLRQLEQRLQESCSVCLAGLDGFRRQQQEDRERLRAMEKLLASVEERQRHLAGLAVGRRPPQECCSPELGRRLAELERRLDVVAGSVTVLSGRRGTELGGAAGQGGHPPGYTSLASRLSRLEDRFNSTLGPSEEQEESWPGAPGGLSHWLPAARGRLEQLGGLLANVSGELGGRLDLLEEQVAGAMQACGQLCSGAPGEQDSQVSEILSALERRVLDSEGQLRLVGSGLHTVEAAGEARQATLEGLQEVVGRLQDRVDAQDETAAEFTLRLNLTAARLGQLEGLLQAHGDEGCGACGGVQEELGRLRDGVERCSCPLLPPRGPGAGPGVGGPSRGPLDGFSVFGGSSGSALQALQGELSEVILSFSSLNDSLNELQTTVEGQGADLADLGATKDRIISEINRLQQEATEHATESEERFRGLEEGQAQAGQCPSLEGRLGRLEGVCERLDTVAGGLQGLREGLSRHVAGLWAGLRETNTTSQMQAALLEKLVGGQAGLGRRLGALNSSLQLLEDRLHQLSLKDLTGPAGEAGPPGPPGLQGPPGPAGPPGSPGKDGQEGPIGPPGPQGEQGVEGAPAAPVPQVAFSAALSLPRSEPGTVPFDRVLLNDGGYYDPETGVFTAPLAGRYLLSAVLTGHRHEKVEAVLSRSNQGVARVDSGGYEPEGLENKPVAESQPSPGTLGVFSLILPLQAGDTVCVDLVMGQLAHSEEPLTIFSGALLYGDPELEHA
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSLLGAVGGAPWRCPGRLFACHFSHAARRGEELSRLLLDDLAPTSRSSRGLELLFGLAPCLLALRAARRRVARLLLQAGRSGLQGERAELLREAEARDIPVLRPRRQKLDALCRHQVHQGVCMEVSPLKPRPWTEVEEARPGDDPRRLWLVLERLQDPRNLGAVLRSAHFLGVDKVITSGRNSCPLTPVVSKASAGAMEVMDVFSTDDLAGFLQAKARQGWLVAGTVGCPRPEMSSEIPITSCLEFLWDQPTLLVLGNEGSGLSQAVQASCQLLLTILPGRQLPPGLESLNVSVAAGILLHSICCQRKDFPMGRKREHLLQDPREPSATSEGPGLAQHPGLSSGSEERQNGS
The following text describes a protein:
Function:
Defense against chitin-containing fungal pathogens.
Sequence:
MKTTLPTLLFAGLFLAGILLPDPVASQSCNCGRQECCSKYGYCGTTQEYCGKDCRKGPCSLPAPNNNADVPGIVSTAFFNGIVAKSASNCPGRSFYTRDTFLRVLRDYPHFGRSGSIDDSKREIAAFFAHVTHETGHFCYIEETGGRSKDYCDRTKQKDYPCISNKGYYGRGAIQLSYNYNYGEAGKNLGIDLLRNPDIVATDQVVSFKTALWFWMEHAHWDFASGNGFGASIRAVNKIECDNGNAAAVTSRVSYYTDYCRQFGVQPGGNLRC
The following text describes a protein:
Function:
Probably involved in steroid metabolism. Catalyzes the oxidation of androsterone (3alpha-hydroxy-5alpha-androstan-17-one) and 20beta-hydroxyprogesterone (4-pregnen-20beta-ol-3-one), and the reduction of progesterone (4-pregnen-3,20-dione). Shows a preference for NADH. Has no detectable activity for oxidation of L-3-hydroxybutyric acid and only an insignificant activity for reduction of acetoacetyl-CoA.
Sequence:
MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAVAAELADAARYVHLDVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRVNSIHPGLVKTPMTDWVPEDIFQTALGRAAEPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEWVT
The following text describes a protein:
Function:
Couples the hydrolysis of ATP with the export of cadmium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSKASKQTTYRVDGMSCTNCAGKFEKNVKNLEGVTDAKVNFGAGKISVYGETSISQIEKAGAFENLRVTDEKDYSSKPAKKESFLKKNWHLVVSIIFIILAFISQNISGEDSTTTIILYVIAIVVGGFNLFKEGFANLIKLDFTMESLMTIAIIGASIIGEWAEGSIVVILFAFSEVLERYSMDKARQSIRSLMDIAPKEALIRRDDVEQMIAVSDIQIGDIMIIKPGQKIAMDGVVIKGYSAINQSAITGESIPVEKKVDDEVFAGTLNEEGLLEVKVTKHVEDTTISKIIHLVEEAQGERAPAQAFVDKFAKYYTPTIMLIALLVVVVPPLFFGGDWDTWVYQGLSLLVVGCPCSLVISTPVSIVSAIGNSAKNGVLVKGGIYLEEIGGLQAIAFDKTGTLTKGKPVVTDFIPYSEHMDEQNSLSIITALETMSQHPLASAIISKAMIDNVDYKSIEIDNFSSITGKGVKGEVNGITYYIGSSKLFESSLEKSQSISQTYQSLQKQGKTAMLFGTESNILAIIAVADEVRESSKEVIAQLHKLGIAHTIMLTGDNNDTAQFIGKEIGVSDIKAELMPEDKLTYIKELKQTYGKVAMIGDGVNDAPALAASTVGIAMGGAGTDTALETADVALMGDDLKKLPFIVNLSRKTLKIIKQNITFSLGIKLLALLLVLPGWLTLWIAIVADMGATLLVTLNGLRLMKVKK
The following text describes a protein:
Function:
Acts as a component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export.
Subcellular Localization:
Nucleus.
Sequence:
MSVKARRISGRLETVVTKVNYAFDPVDDDKIIRNRLLTRTTTTRGEPPLKKLQKKFTSFVLEVDKEEENYNDCGRLAKAFLQELSTFEIPLLKSQAVVEANLREKESFNEVKDETERQIMQAKAEIEDLKKQLEESKIDRQHKEECETIRKLISAQPPRSETEKVIYELNKEIAELEAESTASWRLLELRKKQFALLMHVVDELQNTMEDEQKSLVDEIRSASEDQRNITDAMSVD
The following text describes a protein:
Function:
May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.
Sequence:
MPAALNLSNEVVKMRAEVKRIKVFLIRKLSRQISALQKKKGNEASLEKNGRRAARLREEIRELKAVVPDSVTKAALQKDISFEKVCRDKEASLTDRATARIATHPEFSKKIQSLKAAIKAFKEERMNARKAEKQAKGSAESDSSQDTDEEDDDGSERSNNRDDEDGLKEDEYDKKTDELIDSSSQETLNKQTNQCQEEERLDEEGSSEAVSISEEVIRMRKEVKRTRVAIISKLAEEVAFLKKKKGEEYEVKESQERAAVLLKEIQALRSLKPDQVTMTALQENMELEKILLDNEASPIDRAIAHIATHSRFINKLQKIKEEKIKAAEAEKKKTDKPDTVQSKNEDEELEEEDEEEVDDDDNDDDDDDDDSSDESEENCDKVGEKSNRVFNQIDKSGVVEPDTSAEPDTFEMPQSKTDVMAPNDQNFSSTASNVQRSEKSLTASHVQRSPKKSSTGSNVKKSPEKTSTSIVQNSPKKSSFAPNVQISPKKFSTTSNIQSSSKKSLTVSNTEFKNFGKADKEKKTTLKPQKKQDVPQTERLDAEKDDEESDLSDDEEEEEKEYFDDSTEERFHKQSSQSEDSDDDDFFMGKVSKFKKRKSNQSKVVEKKRELPNADKEVTSKPRHDSLGKLESVFCSTLSKSNVSSQKAKYGSRNDGQRPPRFQNQRKGPEGRMKASQYKGQDLGSDKRTSSFTSERQTFKAAGQMQAGPSGAGRGKPKFENRQNQNSKGPPGKMSNQPQQSLHPSWEASRKRKEQQAQITAFQGKKIRFDDD
The following text describes a protein:
Function:
Membrane-anchored forms may play a role in cellular adhesion.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Secreted.
Sequence:
SWTHCLWPQHLPALGRLSQDDQCTPPHRRGPQSGCPAELRPHPPAVPCCPLLWAPGQGSFPRRAGCQRGQPVGQCQLLPAARLLVPAGQPAAPGPALSPNPEAGLAAGPPPGLAGEREGVCLANLASRCGLQDDFTLHPPNLLLFYNLSQVREADCRAFICRAAQGDVELLSHLPDQRVALRRAAGACLVGAGWGWAQCIGGSLPLGADLLALQGVARPRLSASDLQLLGALVCDMDSSSIGAADPRVLENLRRCPRLTAAQCIALNSLLAGGKTSLGWVGSQAGRGTGTWATNLSPHLPRQAVGLGFFHSVVASCRVGKLGQREASCFVTSFLESKTKPVSSRPRLSTGNITAATLQDGLFLVHYDCAELESCLDGRILRTNLDTLLQHPLPTECQHVVKAKLAQVYPQGLPEDQLRLITSLVYLYSRTEISQWSITSQDTVVALLAPDVALENQTEAVLQKFLEHNGTVSGALLLAIGGTRLCWMSPQQIQTIHPQELRLAGALDLSSCPQSRKDVLYAKAREAFGSSRTPAAYYRLMRPYLGEAGSPGGAPAPSPAAPPGGPTAPLPHPSPQSLDVGNVTALLGHNVGDLQKARSHPTLSLDASPAGPTGPAHGTRGPPSTPTQSVHLGLPGTNVAAGPPPS
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Miscellaneous:
MISCELLANEOUS: Present with 1630 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MDRDTKLAFRLRGSHSRRTDDIDDDVIVFKTPNAVYREENSPIQSPVQPILSSPKLANSFEFPITTNNVNAQDRHEHGYQPLDAEDYPMIDSENKSLISESPQNVRNDEDLTTRYNFDDIPIRQLSSSITSVTTIDVLSSLFINLFENDLIPQALKDFNKSDDDQFRKLLYKLDLRLFQTISDQMTRDLKDILDINVSNNELCYQLKQVLARKEDLNQQIISVRNEIQELKAGKDWHDLQNEQAKLNDKVKLNKRLNDLTSTLLGKYEGDRKIMSQDSEDDSIRDDSNILDIAHFVDLMDPYNGLLKKINKINENLSNELQPSL
The following text describes a protein:
Function:
Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localization ofAMPA-type glutamate receptors in the postsynaptic density.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Synaptic cell membrane; Single-pass type I membrane protein. Postsynaptic density.
Sequence:
MEAARTERPAGRPGAPLVRTGLLLLSTWVLAGAEITWDATGGPGRPAAPASRPPALSPLSPRAVASQWPEELASARRAAVLGRRAGPELLPQQGGGRGGEMQVEAGGTSPAGERRGRGIPAPAKLGGARRSRRAQPPITQERGDAWATAPADGSRGSRPLAKGSREEVKAPRAGGSAAEDLRLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLYDFNLGSVTESSLWRSTDYGTTYEKLNDKVGLKTVLSYLYVNPTNKRKIMLLSDPEMESSILISSDEGATYQKYRLTFYIQSLLFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNRFYWSVAGLDKEADLVHMEVRTTDGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQDEYIFIQVTTSGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAVQEWNQNDTYNLYISDTRGIYFTLAMENIKSSRGLMGNIIIELYEVAGIKGIFLANKKVDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHLHLQLSENPYSSGRISSKETAPGLVVATGNIGPELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHSWDKYGFTSVPLFVDGALVEAGMETHIMTVFGHFSLRSEWQLVKVDYKSIFSRHCTKEDYQTWHLLNQGEPCVMGERKIFKKRKPGAQCALGRDHSGSVVSEPCVCANWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQSYLNSTGYRRIVSNNCTDGLREKYTAKAQMCPGKAPRGLHVVTTDGRLVAEQGHNATFIILMEEGDLQRTNIQLDFGDGIAVSYANFSPIEDGIKHVYKSAGIFQVTAYAENNLGSDTAVLFLHVVCPVEHVHLRVPFVAIRNKEVNISAVVWPSQLGTLTYFWWFGNSTKPLITLDSSISFTFLAEGTDTITVQVAAGNALIQDTKEIAVHEYFQSQLLSFSPNLDYHNPDIPEWRKDIGNVIKRALVKVTSVPEDQILIAVFPGLPTSAELFILPPKNLTERRKGNEGDLEQIVETLFNALNQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRKIPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFTEPEELLDKELDTRVIGGIATIANSESTKEIPNCTSV
The following text describes a protein:
Function:
Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria including M.luteus, S.aureus, Streptococcus, P.micros, P.acidilactici, C.sporogenes, C.diphtheriae, A.viscosus, G.vaginalis, P.acnes, L.monocytogenes and M.smegmatis, and Gram-negative bacteria including C.jejuni, H.pylori and N.gonorrhoeae. Transiently and partially depolarizes the transmembrane electrical potential and pH gradient of susceptible cells, inhibits the uptake of amino acids and depletes the intracellular ATP pool.
Sequence:
MNKLNSNAVVSLNEVSDSELDTILGGNRWWQGVVPTVSYECRMNSWQHVFTCC
The following text describes a protein:
Function:
Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
Sequence:
MATLFTKPKKKIVFLASGRGSNLRAVLQNIKVGKIRGIAQTLICDHPDAKALEVAQEFELTSQVLNFSSFSNKSEYHTKLLQLLLEIKPDLIVTAGYMRILKSPIIQTFSNRIINIHPSLLPAFPGLNAQKQALEYGVKIAGCTAHFVDEGIDSGPIILQGVVKIEEGMTERDLTLEILKEEHKILPLAVQYFCEDRLTIQNRKVKIG
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Sequence:
MGGCLSSDSDVPKSKPQPAPQPSSNQQAASGKGATKFAVPTGAPTKKINITPKRAVGVSNSADEDAFKICIVGAGESGKTTFTRNMVLNYLGGINDKDRRSEIVTIRGNMIDAIKDLIKFVQSEGLESELPDDEEEFIQNLLDVDAFDADFSELAAGLHKIWNCDVIQKAYYHTSQVVVPDNMDYFFEKYLEIAKEDYVPTDGDLLRVRVRTIGIKPMVFDLEGARFQLTDVGGQICERKNWQKVLEGTEAVIFAFSLAEFDRKMFEKPEELRIDDSIKLFEATVNGETCSECPIYLVGNKYEKFCKKIQETDAFGAAFPDFQGNIHDPLATSEYLFKLFKDKMVQNGSEYHTFQTFTMTAIDSQSVIKVAESVFEDLNRRFFCD
The following text describes a protein:
Function:
DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
Subcellular Localization:
Nucleus.
Sequence:
MHHQKYLQRFLGGKREKKQKEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MVAYLNIHTAYDLLNSSLKIEDAVRLAVSENVDALAITDTNVLYGFPKFYDACIANNIKPIFGMTIYVTNGLNTVETVVLAKNNDGLKDLYQLSSEIKMNALEHVSFELLKRFSNNMIIIFKKVGDQHRDIVQVFETHNDTYMDHLSISIQGRKHVWIQNVCYQTRQDADTISALAAIRDNTKLDLIHDQEDFGAHFLTEKEINQLDINQEYLTQVDVIAQKCDAELKYHQSLLPQYETPNDESAKKYLWRVLVTQLKKLELNYDVYLERLKYEYKVITNMGFEDYFLIVSDLIHYAKTNDVMVGPGRGSSAGSLVSYLLGITTIDPIKFNLLFERFLNPERVTMPDIDIDFEDTRRERVIQYVQEKYGELHVSGIVTFGHLLARAVARDVGRIMGFDEVTLNEISSLIPHKLGITLDEAYQIDDFKEFVHRNHRHERWFSICKKLEGLPRHTSTHAAGIIINDHPLYEYAPLTKGDTGLLTQWTMTEAERIGLLKIDFLGLRNLSIIHQILTQVKKDLGINIDIEKIPFDDQKVFELLSQGDTTGIFQLESDGVRSVLKKLKPEHFEDIVAVTSLYRPGPMEEIPTYITRRHDPSKVQYLHPHLEPILKNTYGVIIYQEQIMQIASTFANFSYGEADILRRAMSKKNRAVLESERQHFIEGAKQNGYHEDISKQIFDLILKFADYGFPRAHAVSYSKIAYIMSFLKVHYPNYFYANILSNVIGSEKKTAQMIEEAKKQGITILPPNINESHWFYKPSQEGIYLSIGTIKGVGYQSVKVIVDERYQNGKFKDFFDFARRIPKRVKTRKLLEALILVGAFDAFGKTRSTLLQAIDQVLDGDLNIEQDGFLFDILTPKQMYEDKEELPDALISQYEKEYLGFYVSQHPVDKKFVAKQYLTIFKLSNAQNYKPILVQFDKVKQIRTKNGQNMAFVTLNDGIETLDGVIFPNQFKKYEELLSHNDLFIVSGKFDHRKQQRQLIINEIQTLATFEEQKLAFAKQIIIRNKSQIDMFEEMIKATKENANDVVLSFYDETIKQMTTLGYINQKDSMFNNFIQSFNPSDIRLI
The following text describes a protein:
Function:
May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MRFVFRRLLPASTAAVAAPPSLLSMRGAPSFVHPPAEEAIGKDVRATPANWVTAYVLPEVITEQEEKTLLDFSEPWFERLSYNDGHMDGLIHHYKEFYRSYAAITQAAETGSDAGLNMPHANLEVDLPLVSEALARAHDLAQTYLPCIPIDDRVHFLRLAGSGFIRAHVDESRNSTGIVAGLCLNAGRVMTLTHPAYPGERVELMLAPRCLYILIGRARYDWAHSVDWVGDDDEHIRRIQKSLAVEGTPIRFDGAETPYRRSDRTAIIFRGVSPMTLLVRRMRQRG
The following text describes a protein:
Function:
Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.
Subcellular Localization:
Cell envelope. Cell membrane; Lipid-anchor, GPI-anchor. Membrane; Lipid-anchor, GPI-anchor.
Sequence:
MLQCILIALILTVSITANVHPIIIHGHYFIDSITKEPFYIKGIDYQPGGSSAVSELNDPLSDPDKCARDIILFQELGINTIRIYSINAHLNHDKCMTMLAKAGIYLFLDVNSPLPHHHLNRYEPWNSYNLYYFENVFKVVEQFSHYNNTLGFIAGNEIVNDPISASVAAPYVKAVVREIKSYIEYNAPRTIPVGYSAADDLNYRMPLAQYLECGDDNPKESVDFYGVNSYQWCGDQTFYSSGYNILVNDYKHFTKPMFFSEYGCNEVLPRNFDEVPVLYTNDMIDVFSGGLVYEFTQEPNNYGLVKVLSNGDVKVLRDFIQLKNKFDTLPELDYSYIIQSMKENAKDIHQKLTTFKTSIPKCELSYPNLDISRGVPPTIAQTLIETGVDAKRGEYVTLSNEDLTTTYKFFQESGEKLAIVNRIETMVEVDEKALENRETPQEPAESAEPAEPTEPAEPPSPPPSTPFIDFIHKLIDPFKTFCANLFN