lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Short-lived chaperone present in the precursor form of the 20S proteasome and absent in the mature complex. Required for the correct assembly and enzymatic activation of the proteasome. Also prevents premature processing of the PRE2 propeptide.
Miscellaneous:
MISCELLANEOUS: Present with 2740 molecules/cell in log phase SD medium.
Sequence:
MNIVPQDTFKSQVSTDQDKSVLSSAVPSLPDTLRQQEGGAVPLSTQLNDRHPLESTLKNWETTQRQRQMEQYRQIFGIAEPMKRTMEMEIVNRTDFNPLSTNGSIHRDILLNKECSIDWEDVYPGTGLQASTMVGDDVHSKIEKQLGI
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs).
Subcellular Localization:
Cell membrane.
Sequence:
MGCVGGGADQEGREARKVNKQIEEQLAKDKQVMRATHRLLLLGAGESGKSTIVKQMRILHINGFNADEKREKIKDIRRNVRDAMQVMLKAMEEIDPPIALDQPSTAASRDYVMSVTNDPEDNYPPEFYDHILVCWKDKGVIACFERSSEYQLIDCAQYFLDKVDIVRQNNYDPSEQDILRCRVMTTGIFETKFEVDKTPRIACPIQKHLEQQMAENHLGHFVPQQTGLVVREDQSQRYLLESFFPEFEGYNLPNDAVYDNQEDRDVVRAKYFIRGEFLRISTANSDGRHHCYPHFTCAVDTENIRRVFNDCRDIIQRIHLRQYELL
The following text describes a protein:
Function:
Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome. Component of the EGO complex, a complex involved in the regulation of microautophagy.
Miscellaneous:
MISCELLANEOUS: Present with 2740 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane.
Sequence:
MGAVLSCCRNHSGEENEALLREQQAGYGSQGNANDEYDAEQMRLKEHEHEQKLLAREQELRDIVANTNDKLIDISMINNSGIVIQGTDLQEALDKRQQEEGGDSREDERSAGDDNLSGHSVPSSGSAQATTHQTAPRTNTFTLLTSPDSAKISKEQLKKLHSNILNEIFSQSQVNKPGPLTVPF
The following text describes a protein:
Function:
Putative receptor kinase that may be involved in cytokinin signaling.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MALLLWVFSCSLFSLWILSFMRSQATEARHGTLAVMCDERARILQDQVKVSMNHLQALAILVSTFHHSKSPSAIDQTTFARYVERTAFERPLTSGLAYAARVTHSERELFERQQAWSIRAMNFSSKRPRAEEYAPVIFAQDAYKHVVSIDMLSGAEDRGNLLRARESGKVVLTAPFQLLNKRIGVVLTYAVYKSELPLNATVHDRIQSSIGYLGGVFDIEGHVDKLLEKLAGKEPMTVNIYDTTGESMIRMYGSSNESASGMCHVSTLDFGDPLRKHEMHCRFTQGPPWPWLAVASSYGTLVISLLVGYIFHFTDKWIAKVEDGYKATDMQMPAKDEFAATERISDMERDLKEDALFFDTTKSPSLLEISRLLNHRDPAQNVHQEEQELNLPLEAQDKLKETERKLGRMSKFITKVMKLTSASIRCLPSRFHCFNKKVWSISLLGFLLFILVIGAFDQPYNQPLGMGGEGDNNMMLKNFGFSRGRLLIDTLHGTWTKRGVQSSDTIRVDLRKMTRNNDSSGQQLKHWSSHKSSEIPAVLYVPMNGKQVIVHCNLIVDEKALVNWISNGDTDQSSKYQKETAGIQNRTDKPHLPANKSHKTTVSPWIVLLPVIMLVLLGSIIWRRCNDHRRRVQQKELELLGIMGPSRFQLQDLVAATGNFADENKLGQGGFGPVYKGYLRDQDLHVAIKVLSRRQSCQEQSAQGLREFKAEVKVMTQLRHRNIVKLVGWSDSKKQLLLVYELMAQGSLDKHLYDPEKILTWQQRYQIKFANLFNSTDKIVLDLGSALLYLHHDCEKCIVHGDIKPANVMLDVSHNAKLGDFGLARLVEHGGEPQTTQVVAGTPGYIDPEFINNRWPRTELDVYSFGIVLLEIACGKRPASRQLPNGASSLLAWVRDLYDQGKILDAADQRLNGEFNQQQMERVIVMGLCCSHQDPIQRPSIVQAMDVL
The following text describes a protein:
Function:
Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
Sequence:
MLFRVSGRIASKSQFKFSSLKAQLHDLIYRDDKSSDLYKLAAASPQSAVGQKGSEIREQERRYEVTKLSNGITVLSESASSPSRVDVGILLDVGTRDETNETSGSLLSIKNTYYKTVLNTNETINYGVIQQSGGEFEMDYDQESAYFKAHCLAHDVVDVFKVVADCALEPRSVVAANAAIEKNHGTHNLENIIKSGEGFNETIFKTAFGLTGLGMPLRGFKTNIGNLSAYTIQKFQLENINPSKIIVAGAGIYNHTEFVSLVQDSLGFIPAGQTAKVRAQTQYVGGEVRNLTDDNEIAIALLFPSANWTNSQAAVFQVLNALLGLQGSAQSRLQRNILNKNSYADVVESLNFTFSDAGLFGVKIIGSADKGTELLSSVVNELKTLTGPISNTELTRAKNILKTQLYLALERTSDRLEEAAKSLKVFNAIKITEYASYIDAVTSDQINKAVVDLLKNRPTLVAEGGLANRLPSFDQVLNQLK
The following text describes a protein:
Function:
Protein kinase important for axonal elongation and axonal guidance. Functions in the CAN axons to direct both anterior and posterior migrations. Phosphorylates both unc-14 and vab-8. Component of the unc-51/atg-13 complex that is probably recruited by lgg-1 to preautophagosomes and is required for autophagosome formation. Interaction with autophagy related proteins such as atg-13 links it to the autophagy machinery to in turn promote P-granule degradation in somatic cells. Plays a role in mitophagy during limited food availability. Regulates cell size. Plays a role in male tail ray pattern formation. May be required for normal dauer morphogenesis.
Domain:
The LIR motif (LC3-interacting region) is required for its interaction with lgg-1.
Sequence:
MEQFDGFEYSKRDLLGHGAFAIVYRGRYVDRTDVPVAIKAIAKKNISKSKNLLTKEIKILKELSSLKHENLVGLLKCTETPTHVYLVMEFCNGGDLADYLQQKTTLNEDTIQHFVVQIAHALEAINKKGIVHRDLKPQNILLCNNSRTQNPHFTDIVIKLADFGFARFLNDGVMAATLCGSPMYMAPEVIMSMQYDAKADLWSIGTILFQCLTGKAPFVAQTPPQLKAYYEKTRELRPNIPEWCSPNLRDLLLRLLKRNAKDRISFEDFFNHPFLTSPLLPSPSKRILESARSPLLANRRIITPQSSLPVPKRAGSTKLDSPTPVRRIGESPRVQRRVITPGMPSPVPGAPMQESTDFTFLPPRQESSPVKQVQVHTNVSPSLTTCKPVPVPSQRLTYQKMEERLAAARKTAVPSSSSPTGSAVSAQHQHQHQQQQEPASSPVVQRIERPDQLPRRTTLQDPNAHDIERMTMPNPTFVVCGSSTKPSPNNANRVRRSTITSPADTQDMVAADQMLSNLDPTTTTTTIPKSATTANIQGIPRGARDRSVTSPPQPTIHENEPLDNAKYQQTDVNNSPTAPTEPFIIKNQTTCSTSSTSSSVVEEEEAMSLPFASGSHLAAGFKKTPAEVPMDHGALPPALDQEIVLGEEHKQILAKLRFVAELVDTLIHVAEQKDNPLASAMASRRQLLTTGTSTTNTSSPYRRAEQLVVYVRALHMLSSALLLAQTNVANRVLHPSVAVQQVLNQLNDKYHQCLVRSQELASLGLPGQDPAMAVISAERIMYRHAIELCQAAALDELFGNPQLCSQRYQTAYMMLHTLAEQVNCDQDKTVLTRYKVAVEKRLRILERQGFVAAVNT
The following text describes a protein:
Function:
Component of the transcription regulatory complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Acts as a tether connecting the not/nonstop-containing deubiquitinase (DUB) module to the rest of the SAGA complex; regulates DUB module specificity. Important for regulating deubiquitination of histone 2B by SAGA. The SAGA complex predominantly acetylates histone H3. Important regulator of transcription during embryogenesis; required for nuclear anchoring and cellularization. Tethering the DUB module prevents not/non-stop from stabilizing SCAR, preventing its ability to promote actin polymerization.
Miscellaneous:
MISCELLANEOUS: Shares sequence similarity with the 3 sequence blocks that define the Ataxin-7 signature in other species, however the order of the 2nd and 3rd blocks is reversed in drosophila.
Subcellular Localization:
Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on polytene chromosomes.
Sequence:
MPLNDVAPAGGGAYPENGTKHKVSGMWKPDSSAGSNSGSGSAGLSLFSLQGQKWQQVFDMEKVIKQLRTAEKTYLRGGKNSSAGADQQAKVQVQRLQSADMAYYDLAPKLASRDIVLCSSCSGCYTKAGFQHHIALQHPSVWEATSSKVNPNPNGTAISSDSRLTATEISQEGGAIVPSSPTDTLSASTLSSCSNGSSSSASLQHPAAAGSSSTTSSSSSSRHKSSSSKSSSSSSSKGSSSTSAGSRSRSKSSKNRHHSSPAPALLESNHKESKGSKKSSAIAAPPVVAAVVKEEPPSVGAAPAAITMFSSSSNSSCSLPPTPTLGAASSEVAMGVNYSPAQLQTDAEKLPELQPKKKLKGSSDHRIKAEKEKNKDKSLVNSYEQQQVLSELDQAVSSITGAVSAEQVAPDEEELPLPNTSDENSISQTLDEMLDSKLINEILNNFDESALDTSQQQSQQQAQNGSLSHPAQATKRLRFEDGTIGEDYAVYQQQAVQQVYGEEEHQQELTTIDAMQLQQLIYQQQQMLEQQQLQEQQQQQQQDQKLQDHEQQRQFSVYNVPSLTDEAMVNPQQQQLEEHMILPSIIYEITESNPVSMLEQKVLAEFLTNAGYENVDVNVVQSGGIQTNLSSGTEANQLADELADFEFSKLETVSDTVKTVKLEAKAASQPPTTNPQINHHPSLANAKYHEDSYFNVMLYSGAPRPLAMNTFGMVKLPQGLGVTFRKNLLTTRKANNNLLSLSGGNHLGVVGQLARTPPPPSPALSNGLPGKNPASGRTIYAQRSNVIAQDRLRCNKRALVGGKAGGGSSGSPGVMTAKRLNELLMGKAKKEEKPPPDSEDGGEQPTKDKERDKEEDNKLTFSFYEKRRRLLAGKLEQLQPLGRPSFTLPLQSNHNASQSQSHSPQQLLKKQLLRTLSDSSSNMNISNMNNISNLNSSNTPSANSNPPWKGNSSNPGGNSTPTSSDLMRVFV
The following text describes a protein:
Function:
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
Sequence:
MNILVVKTPEELAEAGYKLIEEVVKTKENPTLGMATGSSPLGIYAEMRKNKLDTSRVTTVNLDEYVNLPHEDKNSYHYFMQEQLFDHLPFKQTYVPNGMASDLEEECKRYESILAANPVDLQILGIGENGHIGFNEPGTPFNSPTNIVELTESTRQANLRFFEKEEDVPTHAITMGIGSIMKAKQVLLVAMGSKKAEAVKELLQGEYSEECPATVLQRHPNVTVIADQEALSLCSEAIADEHRQVFTISDLLSDSRVGETAN
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MQDSCYNIDFVNFPDSKPDWIFTRSIVKKMEGLPKCLLLSHHGEAKHKHLVSHYDDHFLRPGNSTLPTLRSYDGNRLAWVPERSDYPTADPPTNFGLLQAKEKQWREKFSEEPRSLYSASYKQPPTSAYNTMRFGVAPRVLSSTMYPSNNNNKSMNFREYRHLQVPGFPVHHTHINQPAGSMA
The following text describes a protein:
Function:
Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening.
Subcellular Localization:
Secreted.
Sequence:
MGLLRLLVLCTLAACCMARSPPAPPLPQRPLSPLHPLGCNDSEVLAVAGFALQNINRDQKDGYMLSLNRVHDVREHYQEDMGSLFYLTLDVLETDCHVLSRKAQKDCKPRMFYESVYGQCKAMFHINKPRRVLYLPAYNCTLRPVSKRKTHTTCPDCPSPIDLSNPSALEAATESLAKFNSKSPSKKYELVKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQASCSLQHSDSEPVGICQGSTVQSSLRHVPLIQPVEKSVTVTCEFFESQAQVPGDENPAVTQGPQKLPQKNTAPTSSPSVTAPRGSIQHLPELDDEKPEESKGGSPEEAFPVQLDLTTNPQGDTLDVSFLYLEPGDKKLVVLPFPGKEQRSAECPGPEKENNPLVLPP
The following text describes a protein:
Function:
Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
Subcellular Localization:
Peroxisome.
Sequence:
MSAFLSSQQYGKDKVRLVKVTDLPASTAHGATNLKHQHVQELTCRVLLAGAQFETSYTKADNRLVVPTDTVKNTIYYLAQTTQDTLEDIESFAKVIGRHFIKQYAHVEEVHVRIHAHNWTRIQTSTLEPVPTLAHPHSFYRAGEQKRTTNVVATRVQSRADAMIKFSIASGISDLYVLKSSGSSFEDYHLDKLTTLPPMSERVLSTDITATWTFPDSVESLTQNPSKPTFTPTFHTIKQITLDLFANHNSPSVQNTLYRMGELVLASCPHVKDITYELPNKHVFVYDLKRFGVTNQTGGASTVYYPVADPSGLITATISRSRAKL
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
Subcellular Localization:
Cytoplasm.
Sequence:
MLNTLIVGASGYAGAELVTYVNRHPHMNITALTVSAQSNDAGKLISDLHPQLKGIVDLPLQPMSDISEFSPGVDVVFLATAHEVSHDLAPQFLEAGCVVFDLSGAFRVNDATFYEKYYGFTHQYPELLEQAAYGLAEWCGNKLKEANLIAVPGCYPTAAQLALKPLIDADLLDLNQWPVINATSGVSGAGRKAAISNSFCEVSLQPYGVFTHRHQPEIATHLGADVIFTPHLGNFPRGILETITCRLKSGVTQAQVAQVLQQAYAHKPLVRLYDKGVPALKNVVGLPFCDIGFAVQGEHLIIVATEDNLLKGAAAQAVQCANIRFGYAETQSLI
The following text describes a protein:
Function:
Peptidyl-tRNA hydrolase that cleaves nascent chains-tRNAs that are not stably fixed in the P-site of 60S ribosome-nascent chain complexes. Acts downstream of the ribosome-associated quality control (RQC) pathway to release non-ubiquitinated nascent chains from 60S and 80S ribosome-nascent chain complexes. Does not act on ubiquitinated nascent chains, which are cleaved by ANKZF1 for degradation.
Sequence:
MRPGGFLGAGQRLSRAMSRCVLEPRPPGKRWMVAGLGNPGLPGTRHSVGMAVLGQLARRLGVAESWTRDRHCAADLALAPLGDAQLVLLRPRRLMNANGRSVARAAELFGLTAEEVYLVHDELDKPLGRLALKLGGSARGHNGVRSCISCLNSNAMPRLRVGIGRPAHPEAVQAHVLGCFSPAEQELLPLLLDRATDLILDHIRERSQGPSLGP
The following text describes a protein:
Function:
Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide. Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake. Required for biotin and pantothenate uptake in the intestine across the brush border membrane. Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin. Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MNVGVSPSTTPAPASDADVSASTFSTADYVVFVLLLVLSLIIGLYHAYRGWGRHSIGQLLLADRKMGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHVFIPIFYRLHLTSAYEYLELRFNKAVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLTLGIVCNIYTALGGLKAVIWTDVFQTLVMFLGQLAVIIVGSAKVGGLGHVWDVASQHGLISGIELDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQVQRYLSSHTEKAAVLSCYAVFPCQQVVLCMGCLIGLVMFAYYQEYPMSPQQMQAAPDQLVLYFVMDLLRALPGLPGLFVACLFSGSLSTISSAFNSLATVTMEDLIRPWFPHFSEARATMLSRIIAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGAIVGLLAGLVMAFWIGIGSIVTNMAPGTAPPPANGSSFSLPSNLTTVTVATLMPSTTLSKPTGLQRFYSLSYLWYSAHNSTTVIVVGLAVSVLTGGMRGRTLNPRTIYPVWPRLLALLPVSCQKRLCCRAHSQDLSGDLAGFSEKMSNGMLRRSSDKVAMAVPEEDPAHQGISPTFVLQETSL
The following text describes a protein:
Function:
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.
Subcellular Localization:
Endoplasmic reticulum. Membrane; Multi-pass membrane protein.
Sequence:
MEKSKKYITISVAAFICYCNTLWGSFVFDDTEAIVKNKDVMPYIPLNEIFRNDFWGSNISLNSSHKSYRPLTILSYRLNVLYSNNKLDAFQFHATNVILYGLLCLLTIPVFELFLRKKKTQKSVDDTAYLSSLLFTVHPIHTECVAGLVGRADILCSILFFIVILLYDKAISKKSFVLLCIVVVTTAAAVLCKETAITVLGVCVVYDLFLLKKQRKDWCDIFNIYFFIRTATLVVTGLVILFYRFKIMNFEGPTFTSIDNPAAYADKVFIRIFSYNYIYFLNFLLLLWPQWLCFDWSMGCIPLIERISDKRILIVLIFWIITLISVHHLAKKVVENRFLDAKTMALGLIIFPFLPASNLFLKVGFVIAERTLLLPSAGFCLLVVIGLKKIQSFAPSHKTTVVVLFYTVCVIFTLRSIQRNFEWLREETLFTSALNVCPLNAKVHYNIAKIAGDQNNKTLALSEYKKALELNPNYEQAMNNLANLLREDRKFGEAEALLRKALDVRPNFAAAWMNLGIVLTNLNRTEEAEHCYKTAIKFRNKYPDCYYNLGNLYLDQKRNDEALDAWEMAVLYRPSHVAAWSNTLVLLDSMRQYDKVLELGITALIHNPKSPALHFSLANTLGKIQRFEKAESHFLEAINLNPNNALYHSNLGVLYHRWGKVDKAREMYKKALQIDPHMKTTELNLRKLVNAQD
The following text describes a protein:
Function:
Catalyzes the conversion of D-serine to pyruvate and ammonia. Plays a role in D-serine detoxification.
Sequence:
MNENNDDINNLNTPCVLVLDSVVRNNCIKMNERAASLGVNVRPHMKTHKTIEIGKYQFEENKNLNKSRGIIVSTLSEGKFFSKEFKDILYATPIAPNKVKDAYQLHLSIDRLNVMFDNIEHLKSMVDYAIKNPNEFQKKWSVFLKIDCGYHRAGADPKLQSTTDLVELIVNGEYNQYFQFQGIYSHSGHSYKCQTPTDIKNLAIEEARVTGDYGKKLKSLGYKVDTVSIGSTPVCSHLPHNLLSEYGVNEIHPGNYTFYDQMQYELGNCKLEDIGVHVLATIVSIYPERNELLVDAGSLALSSDPGCTHLRDLKVINNFGIVYNDTNLRIVAPSQEVSKIQSTNQSPIDFSKYKIGSKIRIIPNHSCLTAAMFSDYHVINNDNQIINSFKPNKHW
The following text describes a protein:
Function:
Positive regulator of allophanate-induced genes in S.cerevisiae.
Sequence:
MDESVDPVELLLRLLIRHKPHLKPYAYRQDSWQRVLDEYNRQTGSRYRQSRTLKTKFRRLKDLFSADRAQFSPSQLKLMGALLDEAPEHPRPRTKFGNESSSSLSSSSFIKSHPGPDPFQQLSSAEHPNNHSSDDEHSGSQPLPLDSITIGIPPTLHTIPMILSKDNDVGKVIKSPKINKGTNRFSETVLPPQMAAEQSWSDSNMELEICLDYLHNELEVIKKRQEDFECKVLNKLNIIEALLSQMRPPSQGDKI
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSDHEEDSLYGATELFGEPDGFYEKPAESHFAEYERSAVPAQSARRDTQVRIRLVGSSPLWGHLLWNSAIYTARHLDAHPEQVVGRCVLELGAAGALPSLVAGLLGARQVVATDYPDADLVGNIQYNVDHVIYGGKPPTEAPHVAVEGYIWGNDYGPLRRHLPPGQTGFDLVLLSDLVFNHTEHHKLLQTTRDLLAPAGRALVVFSPHRPWLLEKDLQFFETAAEYGLRAELIEQVTWAPMFADDPGPAEVRARVYAYYLTHCA
The following text describes a protein:
Function:
Amidase involved in auxin biosynthesis (Probable). Converts indole-3-acetamide (IAM) to indole-3-acetate, and phenyl-2-acetamide (PAM) to phenyl-2-acetate. Substrate preference is PAM > IAM.
Subcellular Localization:
Cytoplasm. Nucleus, nucleoplasm.
Sequence:
MAMAGGGRGDYGAFMERFVLPPPPSQQLPLHGLTFAIKDIFDIAGRVTGFGNPDWARTHAPAAATSPVVLAALAAGATSLGTTIMDEMAYSINGENTHYGTPTNPCAPGRVPGGSSSGSAVAVAANLVDFSLGTDTGGSVRVPAAYCGIFGLRPSHGLVSAENVIPMAQMFDTVGWFSRDLSTLSRVTKVLLPLPDDIVKQPTQVTIPMDCFQILGSLDDRTYQIINASVAKRFDSQILDNRNLGDFISDNVPSIGKFITDFSESELPSVPALSVISHVMRGLQRSQFKANHAEWVNTVKPNLGPGLRERILEAIASGDNESLEDFQAIRAEFKSALAALLKDHGILAIPTVPGPPPKVGMEAAPLENFRARAFSLLSIAGLSGFCQVSIPLGMRNGLPVSVSLVARHGADHFLLNVVEELYQTLIDEATKTWSS
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MIGEMDADSVVGYFRGKSILITGSTGFLGKVLVEKILRVQPDVKKLYLLIRAPDAESAKLRIQTEIIGREIFHVLKEKHGVRFNNFIEEKICPLVGDIIYENFGLDSAQLGELSKDVDVIVNGAATTNFFERYDVAFDVNVLGVKHICAFATKCPKLKMLLHVSTAYVAGEQEGIIPEKPILMGETIKAGRKTMKELGLKRARHFGWPNTYVFTKAMGEMMMGLLPMDFPVVIIRPSIITSALKEPLPGWMEGIKTIDSVVIGYAKQTLPFFLVDLDLIMDVIPGDMVVNAMMVAMVAHSEDQQVQIIYHVTSSLRNPAPYAILWKSLFRYFSDNPPCTGRNGEHVRLKKMRFFSSIMWFRLYMAFKYMLPLEMLRLVNIALCGVFSRVYNELSRKFRFMMQLSELYAPYTLFKGCFDDMNLDKLRMAMKKDNQNNNGAYYFDFDPKYIDWEDYFYSVHIPGVLKYTRD
The following text describes a protein:
Function:
May act as substrate-recognition component of the ECS(RAB40) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity).
Subcellular Localization:
Membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Mitochondrion.
Domain:
The SOCS box contains two defined motifs including the BC box that recruits and binds Elongin BC complex, and the Cul box which interacts with the Cullin family of proteins to form a ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex; Switch I, switch II and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.
Sequence:
MSAPGSPDQAYDFLLKFLLVGDRDVGKSEILESLQDGTAESPYSHLGGIDYKTTTILLDGQRVKLKLWDTSGQGRFCTIFRSYSRGAQGVILVYDIANRWSFEGMDRWIKKIEEHAPGVPKILVGNRLHLAFKRQVPREQAQAYAERLGVTFFEVSPLCNFNIIESFTELARIVLLRHRLNWLGRPSKVLSLQDLCCRTIVSCTPVHLVDKLPLPIALRSHLKSFSMAKGLNARMMRGLSYSLTTSSTHKRSSLCKVKIVCPPQSPPKNCTRNSCKIS
The following text describes a protein:
Function:
Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MSFGQNVAATKIELFKYKKSSQVAVMVQKILDDKRKVLLKNIEEMIEEASKARGGIWEPLQDIYSSVNEAYLALGSSTVDSVAESTPSVMEVDVNVRRVVDVKIPALSVTEKDTKSMPYGFADTNSSIDRAAKQIKELLPKICKAAEYENSIFSLAKALEKTQKLLNALENVIIPQYQQKVRFIIATLEEREREEFAKLKKVKAKMESR
The following text describes a protein:
Function:
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
Miscellaneous:
MISCELLANEOUS: The active site is located at the dimer interface; MISCELLANEOUS: According to PubMed:15026039, PdxA may catalyze both oxidation and decarboxylation reactions that directly lead to AHAP.
Subcellular Localization:
Cytoplasm.
Sequence:
MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ
The following text describes a protein:
Function:
Bifunctional protein involved in the biosynthesis of morphinan-type benzylisoquinoline alkaloids. Required for the isomerization of (S)- to (R)-reticuline. The cytochrome P450 module is responsible for the conversion of (S)-reticuline to 1,2-dehydroreticuline while the oxidoreductase module converts 1,2-dehydroreticuline to (R)-reticuline.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MELQYISYFQPTSSVVALLLALVSILSSVVVLRKTFLNNYSSSPASSTKTAVLSHQRQQSCALPISGLLHIFMNKNGLIHVTLGNMADKYGPIFSFPTGSHRTLVVSSWEMVKECFTGNNDTAFSNRPIPLAFKTIFYACGGIDSYGLSSVPYGKYWRELRKVCVHNLLSNQQLLKFRHLIISQVDTSFNKLYELCKNSEDNHGNYTTTTTTAAGMVRIDDWLAELSFNVIGRIVCGFQSGPKTGAPSRVEQFKEAINEASYFMSTSPVSDNVPMLGWIDQLTGLTRNMKHCGKKLDLVVESIINDHRQKRRFSRTKGGDEKDDEQDDFIDICLSIMEQPQLPGNNNPSQIPIKSIVLDMIGGGTDTTKLTTIWTLSLLLNNPHVLDKAKQEVDAHFRTKRRSTNDAAAAVVDFDDIRNLVYIQAIIKESMRLYPASPVVERLSGEDCVVGGFHVPAGTRLWANVWKMQRDPKVWDDPLVFRPDRFLSDEQKMVDVRGQNYELLPFGAGRRVCPGVSFSLDLMQLVLTRLILEFEMKSPSGKVDMTATPGLMSYKVIPLDILLTHRRIKPCVQSAASERDMESSGVPVITLGSGKVMPVLGMGTFEKVGKGSERERLAILKAIEVGYRYFDTAAAYETEEVLGEAIAEALQLGLVKSRDELFISSMLWCTDAHADRVLLALQNSLRNLKLEYVDLYMLPFPASLKPGKITMDIPEEDICRMDYRSVWAAMEECQNLGFTKSIGVSNFSCKKLQELMATANIPPAVNQVEMSPAFQQKKLREYCNANNILVSAISVLGSNGTPWGSNAVLGSEVLKKIAMAKGKSVAQVSMRWVYEQGASLVVKSFSEERLRENLNIFDWELTKEDHEKIGEIPQCRILSAYFLVSPNGPFKSQEELWDDEA
The following text describes a protein:
Function:
Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. Cannot use NAD, NADP, FAD or FMN instead of coenzyme F420 as an electron acceptor. Exhibits nearly no activity with D-mannose-6-phosphate or D-fructose-6-phosphate as substrate.
Miscellaneous:
MISCELLANEOUS: Exhibits Si-face stereospecificity with respect to C5 of coenzyme F420.
Sequence:
MAELKLGYKASAEQFAPRELVELAVLAESAGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVGERTKNLVLGTSVLTPTFRYNPAVIAQAFATMGCLYPGRIFLGVGTGEALNEIATGYAGEWPEFKERFARLRESVRLMRELWLGDRVDFDGEYYRTKGASIYDVPEGGIPVYIAAGGPVVAKYAGRAGDGFICTSGKGEELYAEKLIPAVKEGAAAADRDADAIDRMIEIKISYDTDPELALENTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQVAKRWIVASDPDEAVEKVGQYVKWGLNHLVFHAPGHDQRRFLELFKRDLEPRLRKLA
The following text describes a protein:
Function:
Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase; Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MFDRTIAEAVIKPDCISNFWQAVDIYLFKTHVVNKKLFGVKNVLTLPYKNAPPSAEETFQATEHLLDHIAETELDSFEHETRKRLLCLGCEVREEKVDNISLHEVSQQQYDGAIVLNRLLPKNINVFRPIDVACWIDFRSLRVRLQCLQKDKVTTLFPAFPFSLEVTQRTLSIRCQSTDTVDERSIYWLREVLLERMQKWMETNIPTNATGTSTASIRSLTLVDNLEQYNCLFNELKQKYGQSMVSIWPECTDPQKFVFEDIAIAAYLLMLWRKERTAKGLESLQSFVDIGCGNGLLVYILASEGHRGYGIDLRKRKLWDMYPAEPKVDLRVETIVPSSSSLFPDIDWIIGNHSDELSPWIPVIAARSSYRCRFFLLPCCAYEFDGRKYQRQNCSLSQYGDFLNYAAEIARVCGFAVETDRLRIPSTKRTCLVGSTRTYPEMEYEQQDERVTAFINERSSRVEMEEKLAQNGITEENVPSSGSWSAGFKPRESTEKIRNCTKIDRSVVDKIVAIVFGELLAKRRIPAEFAERSWNAGGTLALEELVKAIPQELLVALKAECGGLQTLLRNNHQIFRVEKGTVQLRIPTRISDTVDAALARKMKKVKNFKPINFKQRVCWFFVNHPDGCPLAEKDCKFNHRS
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MQATSLVLVVACAAICAANRASAAAANEGDNAAAYATLCSAVAVLSTPYAAPSTPEINDALLAEAQALNFSLHHPEAADELAQEGKDSMDKLKKGGKAQKLATEQSFADYKNKAATAKAMAKERPYARVKKTLNNGFLTTQIKKVIDDIQATVDITQKIKVQEHTNTANSKMNKAVYGTDEPNDSVRVVDAAGATTRDAVCGKPGNANAQRRAGKSLKQDIMCICALLTSGQGQTACANLSPALDKDPTGGTDLEDDWKKLHQTCLARYHKNAPTADRIRAVAANVQHTIAQSTANGNKITHILGKTNRDPATNGCNGDVGDNSGCCVYYGRGAGATLTYKIEWAEAMEEAAQAIKAAEQAAAQKTELLAKLTLLNTTLANLAKAAMEAQAAASPTTERAPQQADTKTAEDQEKVCNAAGNDENKCKDLESQGCKYDENKPADQKCTLKKEVKEKLEKEGKKDGATATTVKCSEYGSQDKCEEVNKEKDKPVCGWRSGKDNEDDKDAKKCRNGSFLASKQFALIAVVFDCLVAF
The following text describes a protein:
Function:
ATPase-dedicated chaperone that assists the formation of the RPT6-RPT3 ATPase pair, an early step in proteasome assembly. Plays a key role in maintaining homeostatic proteasome levels and adjusting proteasome assembly when demands increase, such as during proteasome stresses. Function overlaps with RPN14.
Miscellaneous:
MISCELLANEOUS: Present with 2110 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MCSAGGIRRPIQIEEFKTAISGMSDMELAQIKTEIENSINHLQRSNARLGKYIAKLEGADDRLEADDSDDLENIDSGDLALYKDSVRENEIVLNNYNERVDALEQETVYRKTGHGKSKHEVEAKDNTNKGPDVDMDNSNVDVVTPNSIFI
The following text describes a protein:
Function:
Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione.
Subcellular Localization:
Mitochondrion.
Sequence:
MRSPYVKPGKQTADRSTVPDRGATGPSNTYVSFTLKCIMASLLHPQLQLSRQYGRVFSVFNSQIHTGSGLAAKDHYKVLVLGGGSGGIAMAARLKRKVGAENVAIVEPSEMHYYQPIWTLVGAGAKSVASSGRSTSSVIPSGVTWVKSKVAEFDPEKNTVHTDCGKKISYDYLIVALGLELHYEKIKGLPEGFEHPKIGSNYSLKTVEKTWDALKSFKEGNALFTFPNTPVKCAGAPQKIMYLSDAFLRKTGKRSKANIIFNTSLPVLFGVKKYADALWEIVKKRDLNVNLRHNLIEVRADKQEALFENLDKPGETEVFKYEMLHVTPPMGPPAVLKGSLLDDAGGWLDVNKNTLQHKTYDNVFGIGDCTNLPTSKTAAAVAAQSAVLDRTVSRILKKQTPDKAYDGYTSCPLVTSYNTVILAEFDYDGQPLETFPVVDQSKESRVMYHMKADVMPHLYWHGLLKGIWGGPGPYRTMMHLGMK