lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners. Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Central component of the condensin II complex, a complex that seems to play a role in prophase chromosome condensation and organization. Both the condensin complex I and II play a role in meiotic and mitotic chromosome segregation. Plays a role in robust cytokinesis upon the presence of chromatin obstructions. Also a member of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription during interphase.
Subcellular Localization:
Nucleus. Chromosome. Note=During mitosis and meiosis, localizes to condensed chromosomes in both sexes. During meiotic prophase, surrounds the chromosomes, localizes between homologs during meiotic metaphase I, and localizes between sister chromatids during metaphase II. During mitotic metaphase, localizes at the poleward face and to the core of the condensed chromosomes. Requires hcp-6 for the localization to meiotic chromosomes. After the 40-cell stage when dosage compensation is initiated, specifically localizes to the hermaphrodite X chromosomes in interphase.
Domain:
The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer.
Sequence:
MHIKSIHLDGFKSYQKHTDILDFSPTFNAITGYNGSGKSNILDSICFIMGINKLDNIRAKSMHELISHGGTKAIVQVRFDNTDKRCSPFGMEHLDEIVVQRIITAQATGKGCATSYTLNGHAATNGKMQDFFRGVGLNVNNPHFLIMQGRITTVLNMKPEEILGMVEEAAGTKMYDQKKKDAEKTMFLKDAKLKEVDRIFQSSIDPRMVKFREDRKNMVEVTRLKKLKENFSRKYEAFQYFQTCEAVKKSAKEIEDAKKGIEDLGEKFNQLDLDLKNKEDEKKKMEESRDDQHEEAALSAAHLSKQSIMLQKETVKNQLVETINKLKKEGEQINKSLSKDREVLDAKRKEHEDSKAANSKDIQSQSDDEALVTKYRNDLESLTRGTIANDKGEHVSIESEIQSCKSTASQMSSGITAAKKRGERLHNQIKHLEGEKATLSARSKSDIGSADNYQKEVDEINKQLQLLGFNIDADTEKREHAAKLHESITKLKDMDTRLLNSYKDGRYALNYQRPPLHIDKFDEKRDVFGYVAHLIKMKPGCEQFAVAADIALGGVLGNVVVSTQDIARILIDGKAFTSRKTMIPVSENARNASSYNTLPDVKLRRAKEIAEKYNDTVTKMIDLIEYPDFISNTILNAVGQILVVDSLDVAREIAYDEVAKTRMITRRGDDVRTNGIMTGGYNDPGNKPALIALEPMYARRPQIEAQQRELDALNRELQLTEASSQKCRDLNNQLATAMRKLAQVKTNINNSEFGIVVRDLKVHSEEYEKNQAEIEATVKTLKDVEDKIKTLESMKNKDKNSQEKRKKELTALLQKAEQTVAQNKNRGEKARREVMLLQATVEEMEKTIKKDEGIWEQKKKECDELEEKLPNAIAALKDAELEQKAAQAKLNDLKNNQRQISTRLGKIAKECDALIREKAKTKSKREEKEKELTSLQQSEASNRKEARSKLKKFEWLSDEEAHFNKKGGLYDFEGYTVSKGKDEIKELTDKIETLERSCCIQNVSNLDTCEAKVLDIKNKRERITEDFNMLKKTIATLDKKKVDELIRAHESVNKDFGQIFNCLLPDAHASLVPPEGKTVCEGLEVKVSFGGVVKDSLHELSGGQRSLVALSLILAMLKFKPAPLYILDEVDAALDLSHTANIGMMIKTHFHHNQFIIVSLKQGMFSNADVLFQTRFADGHSTCTRLNGGDIAVLCQDKVLQAQALELTDAGKAKKDAAAKKGAQKNDKEPPKKKPIVVDDDDFE
The following text describes a protein:
Function:
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
Subcellular Localization:
Nucleus.
Sequence:
MPKRKAEGDAKGDKAKVEDEPQRRSARLSAKPAPSKLEPKPKKAPAKKGEKVPKGKKGKADAGKDGNNPAENGDGKTDQAQKAEGAGDAK
The following text describes a protein:
Function:
Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLKTIKSYMPGRNMSIFLGFVAGISGAIYYDRRQKNLIIEKYCSQVRHLADQPMAPLELPRKLKVYLHGPPGDGIYVAREEFEEYIRPIFNAAAIEFETVESKGEGNLLEQVARTVYNKRHNISEVSEPEKNLLSVLKPSVDPPAIVLLGRHALKEFLYGVRYGFSDDIMKRKLETEKLEANNKEEKEEKEGKDDKDDKEDSNDTKNDKKISKNEVDSSLIEASPLTGQVPPKFLDTIAIFPLPNLLGFSNTPKRLSRFFKRRELADELGAIAVNVALSRDVTKFPKQDGTLLLAEEETDWPKQFFTRSDLENRIWTAPFLQDSDEIRFFENIDIFDSTKAKQDKYE
The following text describes a protein:
Function:
Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate (P5C) to L-proline using NAD(P)H. Proline is synthesized from either glutamate or ornithine; both are converted to P5C, and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCR3 is exclusively linked to the biosynthesis of proline from ornithine.
Sequence:
MALANLKIGFIGAGSMAQGMIDGWIRANVVKPSQMMASAPTDRNLSKLRAKGLSTTHDNAEVVRSCSVVVIACKPYQCKDVLPALPFGPQHLVLSVVAGLRCPMHEAFLTPGTRFVRTMPNVAIAVCEGNISGVRGAHATDEDMVVVGKLMNPISNYEVMSDPQLDIMSSTAGTGVAWAAMVMEALADGAVNMGLPRSMAMKAAAITLVGTGKLYLETGKHPGEIKDSVCSPGGSTIRGVHALEKSGVRAAMMNAVEAAHTHVLSMSKM
The following text describes a protein:
Function:
Component of the IMD signaling pathway and is required for the host defense against Gram-negative bacteria. Interacts with Dredd, promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MPGNHWYDILKKIACEGSSDIDELKGIFEKELSKRKFDSIRNIEDLIDVLERADMLSLHNVEPLRKMSSHKPKLIEALDRYGTPVSAPREPVNIYQEERLAEELRQHLRISQAFQILSAPGVAPPAFIPAAAPTPPPPQQNYITPAAFTDRKRTAVFNKISEELGRFWRIFGRKAGIGEGTMDDIEERYPRDLKSRILHLLKLIEEDDCHDPRQLLMRLCRALTECGRNDIKRKVEQIMSH
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MKITFKDLKQNKFVIEAEPSETIGELKAKIQADKGWEVPQQKLIYSGKILQDANTVESYSIEEKGFIVCMVSKTPAAPAAPAPLSAVSQNAPATPSPAPATQATGRNFDDPSALTMGNEREAAVANMESMGFARADIDAAMRAAFFNPDRAVEYLLTGIPDSARQEQAQAAQANAPSSPTPAAGGNTGATAAPSGGDEPINLFEAARGGSGGAARSGATGAAAGAGGATALNANSLEFLRNNPQFQQLRQVVQQQPQMLEPILQQVGAGNPQLAQMIAANPEQFLQLLAEDADDDAPLPPGTQAISVTEDEREAIERLCRLGFERDIVIQAYFACDKNEAASCQLPLRPARRRGVERFSPCDGCATPPSRTCILFVDCHHVDVTVS
The following text describes a protein:
Function:
Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.
Miscellaneous:
MISCELLANEOUS: Present with 2070 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MISRTIGESIPPNTKHAVSVCLPTWEATVGYEEGESSIINSLTTGYPRFFIHKSIKKLCEILSAKYSMEDEACLCFPSYKVANRCREFIKVKTGLSTKVRILQLCTPKPMNQEEKLWRRECKITVVFVDQEIFPVMKQYWQHSGEIVSSRMAEYILHELQVKDNLKKMETVDNGKKFMTEDENRVNEEYIETRFGRNLNFLAADKAKYLIRKRIATKVVEKIDSEGLSDLFSFEHYNESNGPFNVGSGEALDDDQLNSDIPAETITSMGESGSNSTFENTATDDLKFHVNPNTDVYLFPSGMASIFTAHRLLLNFDAKRLSRSSSRQDKLIGYGPPFKKTVMFGFPYTDTLSILRKFNHTHFLGQGDSTSMNALKNILHSGEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPYADIVCSSLTKIFSGDSNVIAGSLVLNPRGKIYEFARKFMKTEDGYEDCLWCEDALCLERNSRDFVERTIKVNTNTDILLKRVLLPQVGKLFKKIYYPSLTSEDTKRNYDSVMSTKDGGYGGLFSLTFFNIEEAKKFFNNLELCKGPSLGTNFTLACPYAIIAHYQELDEVAQYGVETNLVRVSVGLENSDVLCNVFQRAIEKALGE
The following text describes a protein:
Function:
Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.
Subcellular Localization:
Nucleus.
Sequence:
MLDMGDRKEAKMLPKSSFSINSLVPEAVQSDNHHAGHGHHPGGHHAPHHHPHHHHHHHHHHHHPPPPPQQPPPPPPQQPPQQPPQQPPQHPPPQARGAPADDDEAKGPPAGQLLLPPPPPPPPQASASSSSSSSSSSSSSSSSSSSSSSSGAPGPDGAKGEGGPGGKGEPGAGPGDPPPPAGQEDKDKGLGVEEKKAGGEAGKEAKEAGEGGDKKNSKYEKPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTTSRAKLAFKRGARLTSTGLTFMDRAGSLYWPMSPFLSLHHPRASSTLSYNGTASAYPSHPMPYSSVLTQNSLGNNHSFSTSNGLSVDRLVNGDLPYATHHLTAAALAASVPCGLSVPCSGTYSLNPCSVNLLAGQTSYFFPHVPHPSMTSQSSTSMGARAASSSTSPQAPSTLPCESLRPSLPSFTTGLSGGLSDYFTHQNQGSSSNPLIH
The following text describes a protein:
Function:
A cognate anti-sigma factor for alternative sigma factor SigF. Alternative sigma factors are held in an inactive form by an anti-sigma factor. Binds ATP and GTP, may hydrolyze both.
Domain:
The cytosolic domain interacts with sigma factor SigF.
Sequence:
MTDQLEDQTQGGSTVDRSLPGGCMADSDLPTKGRQRGVRAVELNVAARLENLALLRTLVGAIGTFEDLDFDAVADLRLAVDEVCTRLIRSALPDATLRLVVDPRKDEVVVEASAACDTHDVVAPGSFSWHVLTALADDVQTFHDGRQPDVAGSVFGITLTARRAASSR
The following text describes a protein:
Function:
Histone chaperone which acts as a cofactor stimulating histone H3 acetylation by RTT109. Preferentially stimulates histone H3 'Lys-9' acetylation by RTT109. May also stimulate histone H3 'Lys-56' acetylation by RTT109. Assembles nucleosomes (in vitro).
Miscellaneous:
MISCELLANEOUS: Present with 3120 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The C-terminal part interacts with the N-terminal part of histone H3 and promotes acetylation of histone H3 'Lys-9'.
Sequence:
MMSDQENENEHAKAFLGLAKCEEEVDAIEREVELYRLNKMKPVYEKRDAYIDEIAEFWKIVLSQHVSFANYIRASDFKYIDTIDKIKVEWLALESEMYDTRDFSITFHFHGIEGDFKEQQVTKVFQIKKGKDDQEDGILTSEPVPIEWPQSYDSINPDLIKDKRSPEGKKKYRQGMKTIFGWFRWTGLKPGKEFPHGDSLASLFSEEIYPFCVKYYAEAQRDLEDEEGESGLSADGDSEDDDGSLGEVDLPLSDEEPSSKKRKV
The following text describes a protein:
Function:
Involved in cytokinesis and septation where it has a role in the localization of F-actin.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSWINPFNKLIAPNKARQTGKQADNDFEKECARFYQFESATKKVYKGMKRYGEAMLALNKAEQRIFQDLASGPLAQTDLLQEPVDEFSKVTAKLDELRQELVSRNQKTFLDPMKRLRSVFPSVNDAIRAREQSFMEYAKHQAKVEKLAEKERTPQNLAKLEQAEKDLAKAKADYERQNAVMLEDLPMLTNGRVDYFEPCFEALILSEASYYSQSAQALTNLTNLLSRSSEQLKIEEQQAQLERKLADLKALSITEDV
The following text describes a protein:
Function:
May be involved in maintaining Golgi structure.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
Sequence:
MLPVDGEERKSEGSDTEGDRTSPCAVSSATLKDLEVGGSGRRCSDPAGQPSNLLPQRGLGAPLPAETAHTQPSPNDRSLYLSPKSSSASSSLHARQSPCQEQAAVLNSRSIKISRLNDTIKSLKQQKKQVEHQLEEEKKANNEKQKAERELEGQIQRLNTEKKKLNTDLYHMKHSLRYFEEESKDLAGRLQRSSQRIGELEWSLCAVAATQKKKPDGFSSRSKALLKRQLEQSIREQILLKGHVTQLKESLKEVQLERDQYAEQIKGERAQWQQRMRKMSQEVCTLKEEKKHDTHRVEELERSLSRLKNQMAEPLPPDAPAVSSEVELQDLRKELERVAGELQAQVENNQCISLLNRGQKERLREQEERLQEQQERLREREKRLQQLAEPQSDLEELKHENKSALQLEQQVKELQEKLGQVMETLTSAEKEPEAAVPASGTGGESSGLMDLLEEKADLREHVEKLELGFIQYRRERCHQKVHRLLTEPGDSAKDASPGGGHHQAGPGQGGEEGEAAGAAGDGVAACGSYSEGHGKFLAAARNPAAEPSPGAPAPQELGAADKHGDLCEASLTNSVEPAQGEAREGSSQDNPTAQPVVQLLGEMQDHQEHPGLGSNCCVPCFCWAWLPRRRR
The following text describes a protein:
Function:
Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.
Subcellular Localization:
Secreted.
Sequence:
MPRGCALLLASLLLAAALSAAPGLGSPVKEKRGWTLNSAGYLLGPQPQHWRKNGASARSRVLPEVPRRMALPPPWVYTVALFSQSSVYAIDNHRSFHDKHGLAGKRELQPEDEARPGSYDRPLPENNVVRTIIEFLNFLHLKEAGALERLPDLLPVASTEDTEQA
The following text describes a protein:
Function:
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis; Upon expression in E.coli functions as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity to produce wax esters.
Sequence:
MVTRLSASDASFYQLENTATPMYVGLLLILRRPRAGLSYEALLETVEQRLPQIPRYRQKVQEVKLGLARPVWIDDRDFDITYHVRRSALPSPGSDEQLHELIARLAARPLDKSRPLWEMYLVEGLEKNRIALYTKSHQALINGVTALAIGHVIADRTRRPPAFPEDIWVPERDPGTTRLLLRAVGDWLVRPGAQLQAVGSAVAGLVTNSGQLVETGRKVLDIARTVARGTAPSSPLNATVSRNRRFTVARASLDDYRTVRARYDCDSTTWC
The following text describes a protein:
Function:
Involved in programmed cell death/apoptosis. Acts by recruiting ced-6 to phagosomes which enables actin-dependent cytoskeletal reorganization and subsequent engulfment of the apoptotic cell corpse. Has a role in the association of ppk-3 and rab-7 with the phagosomal surface which is necessary for the incorporation of lysosomes to phagosomes during phagosome maturation. Activates the expression of unfolded protein response genes, which are involved in the immune response to live bacteria (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Note=Colocalizes with ced-6 and actin halos around early apoptotic cells. Temporally colocalizes with dyn-1 during engulfment of cell corpses (By similarity).
Sequence:
MRLLLLVGVLLAATWQVGYTRAPTFPDKSKSAADAINEPKGEHVCTVKTIVDDYELRKVIHQVVYNDTEQCLNPLTGFQCVVEKRGQKASYQRQLVQKEKYIKQCCEGYYQTKDNQCQPDCNPPCKKGKCVEPGKCECDPGFGGKICSSSCSIGTWGLGCSKKCDCENGANCDPELGDCICPSGFQGKRCEEECPIDKWGPNCVKSCPCQNGGKCNHEGKCVCTDGWGGEYCLNKCEEGKFGADCKFECTCQNGATCDNTNGKCLCKSGFHGALCEKPCSEGFFGAGCTQKCQCLNNQDCDSETGECKCIGWTGKQCDIGCARGRFGLQCKQKCTCPGLEFQDSNASCDAKTGECQCESGYKGANCDERKCSADTYGADCSKQCSCVMSNTVMCAPNTGFCRCKPGFYGDNCELACSKDSYGPNCEKQAMCDWTHASEADPANGKCVCKSGRSGANCSQPCPIDFYGPNCALQCECNGRGIGCHGFDGKCNCAPGYTGHRCEHHCPALTFGANCEKRCQCPAGVGCNPITGECECPAGRQGLKCDISCPEGSYGPECKLHCKCVNGKCDPETGECSCEPGFGGADCSTSCPKGKYGDACELSCDCSDSYCSRQTGKCICPLGKKGTLCDQPCEANTYGPQCQLTTTPSQCASTDPRNGVCLTCPPGSSGHQCEQNCPQGTYGTDCASKCACADGGHGCDPTTGECICEPGYHGATCSEKCPDGKFGYACAQNCPKCAAGSSCDHISGQCVCPAGLEGATCTRPCGVGFWGNGCRQVCRCTSEFKQCNAQTGECSCPAGFQGDRCDKPCEDGYYGPDCIKKCKCQGTATASCNRVTGVCICHPGFTGEFCHALCPESTFGLRCSKECPKDGCGDGYECDAAIGCCHVDQMSCGKAKQEFEALNGGRAKSSGATWLLILFIIGLCGVLGLAALFYRNKYQKEKDPDMPTVSFHKSPNAEDNREFQNPLYNRQSVFPDSGAFSGSSEGGVGAAPDGLLTLEEEDLEDKKIHGGGASRNMRNHDYASLDEVAGGEGGPATSSSSGVQNRRGQNSGDVRRPLLNSEDVDDDDEDEDFEEIPHENRNSTQKLSLERNSKFSEKNFKKKFLSENPYAHIPSPDPNIQNSTNSRRAQENLYT
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSGRFAFNKGLKEVRFLFCQTGEHSAATRSFLLRNYPAMKKDNPATPILIRDASGTLPKVYARFEFGKEKSQSLEGLSDQQIEETVSSLVKNNS
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MQPPKSSSGDIKCSVLERHFAKVVPLLTLIREQFGVELGASSSKNPPNGLSFERWKLLNITLVGIDSLIAAQTPPHRSSQWLSQSGPCTTIHEAVQEAQLQILAKTSTQTSAVARRRYDASNNVLLKGYRRPDDRLESFRITSTGRPGLINLYPNSMVTCLVLNKEWHYLCESIGTERFVWLLVNTSIFVPLLRHGADGTCFVQLTGAALSERTANLGAAANRAQQAGAKRKHGEAGEPTSTTRQRVVIGQAVGAIQTSKPLLTGKRPRKLDRVTSRISARSTSSAPELDIARSQTAASSSVDRKPSEIILVRSRMLYARASRNKNGRVEVGLPSVHVIPRSAIRKELDKVLPSSTAPNKPTARSKPLTRNCIANSKQDVKSPEALFHQRRTRHLAKYVFPRHFGLHNVFTGARDYDTTTQPFRDYTVREVEIKALGAVRTPKALRPVLKVLAKILARHDKINYRALLDRCCPSRVPKGRLTAQERQQIVQDLAEVESLEPTQCQDVPVKPTRKESGCAATSTIQTKVIQVPSDAAPVKAPAKATIELASPALRKPRYTNYAVPTVGQVVHFVTMTIKSLLPRDLFGSLHNQTLLLDTIADFVRLRRYETFNLHQIAQSFRFTDVDWALPAGAVKANRRLTRQEAESRKALVFELLYWLFDGLVIPLLRTTFYITETAAYRNKVLYFRQDDWHVLSRPVLGQLKETIFEPLTRAEALSMMSSRKLGYSHVRLLPKETGVRPIVNLRRRSTKQVHTYQQASQDAAGAKTKKLKLSAALAKQKRESLILGQSINYILQSVFHVLTYEKSRMLTDAGDEDGGGAWRGVDGVGADMLSSSVFGPNEIYARLKMFKQKLLQDRSRAGGVRGKGKLYFVKVDVRCAFDSIDQSKLLEIIEKILCKDGADHDSEGYRIHRFAKVMASATHETRSSSACAGVAPVGKATKRAFVQLARPDSEHIDFFSLASTLAVALHDVVFVDGVSYRYESTSVILKLLRQHITENLIKIGREFYRQRVGIPQGSSLSTLLCSFFYAEMGARDAFLSTLGSENAGAKQRSLLMRYTDDFLLVTTSKKTAKKFYEVMRKGHPDYGCFISAEKTLTNFDLIDSNSTSSPLVARIYKDEFPWCGLTINTRTLGVSTDLTRYAGLDIRDTLTVEYCRRPGAALVEKMIQSVKARCHILFTDTALNGDTRVYGSIYSSFLVAAFKFTAYLAELRRFKRQFTPEFLWKAIQRLVRFTSRYIGSRASSAKFKRQAMNKRQNSARRAPAGRGAGRGRGRGTGRSRGASAAWKVSCTIRPHYVHWLGYSAFRMVLLRQAGARTKHVGMFRRLDRDTRESLIGMIHTAAAQSSFAAARSKLAPVTARVFRDAQKSLSI
The following text describes a protein:
Function:
Protein kinase that acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylating and inhibiting the mitosis-promoting cyclin B-bound CDC28 at 'Tyr-19'. SWE1-mediated inhibition of CDC28 acts in a cell size or morphogenesis checkpoint to delay mitosis in response to defects in growth, actin organization or bud formation. Inhibits the activity of B-type cyclins in replication initiation strongly for CLB2, moderately for CLB3 and CLB4, and there is no apparent inhibition for CLB5 and CLB6, correlating with the normal expression timing of those cyclins. Hyperphosphorylation and degradation of SWE1 when all checkpoint requirement are met releases CLB2-CDC28 from inhibition and allows for progression through the cell cycle. SWE1-dependent CDC28 phosphorylation is also required for pachytene arrest upon activation of the recombination checkpoint during meiosis. Also involved in the regulation of nitrogen starvation- and short chain alcohol-induced filamentous growth, or filamentous differentiation in response to slowed DNA synthesis. Can act both on serines and on tyrosines.
Subcellular Localization:
Bud neck. Nucleus. Note=When SWE1 first accumulates in G1, it is localized to the nucleus. After bud emergence, a subpopulation is recruited to the daughter side of the mother-bud neck through HSL1 and its adapter HSL7, where it is susceptible to hyperphosphorylation and degradation.
Sequence:
MSSLDEDEEDFEMLDTENLQFMGKKMFGKQAGEDESDDFAIGGSTPTNKLKFYPYSNNKLTRSTGTLNLSLSNTALSEANSKFLGKIEEEEEEEEEGKDEESVDSRIKRWSPFHENESVTTPITKRSAEKTNSPISLKQWNQRWFPKNDARTENTSSSSSYSVAKPNQSAFTSSGLVSKMSMDTSLYPAKLRIPETPVKKSPLVEGRDHKHVHLSSSKNASSSLSVSPLNFVEDNNLQEDLLFSDSPSSKALPSIHVPTIDSSPLSEAKYHAHDRHNNQTNILSPTNSLVTNSSPQTLHSNKFKKIKRARNSVILKNRELTNSLQQFKDDLYGTDENFPPPIIISSHHSTRKNPQPYQFRGRYDNDTDEEISTPTRRKSIIGATSQTHRESRPLSLSSAIVTNTTSAETHSISSTDSSPLNSKRRLISSNKLSANPDSHLFEKFTNVHSIGKGQFSTVYQVTFAQTNKKYAIKAIKPNKYNSLKRILLEIKILNEVTNQITMDQEGKEYIIDYISSWKFQNSYYIMTELCENGNLDGFLQEQVIAKKKRLEDWRIWKIIVELSLALRFIHDSCHIVHLDLKPANVMITFEGNLKLGDFGMATHLPLEDKSFENEGDREYIAPEIISDCTYDYKADIFSLGLMIVEIAANVVLPDNGNAWHKLRSGDLSDAGRLSSTDIHSESLFSDITKVDTNDLFDFERDNISGNSNNAGTSTVHNNSNINNPNMNNGNDNNNVNTAATKNRLILHKSSKIPAWVPKFLIDGESLERIVRWMIEPNYERRPTANQILQTEECLYVEMTRNAGAIIQEDDFGPKPKFFI
The following text describes a protein:
Function:
Transcriptional activator.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNSKECAEVSENSHHIKVFLPKKLLECLPKCTLLPKERLRWNTNEEIASYLITFERHEEWLSSAPKTRPQNGSIILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGMECLYGCYVHSSIVPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKICGPILCATNSDRKEWMKWSKEELISQLKPMFHGIKWSCSNGNGTSEFSIEQLVQQILDTHQAKPPPRTHTCMCSTSLGSTGGVPHKCTSTKHRIISPKVEPRMCPLPALTEVQNISSSAEPDQGKERRATPKGCRTPSGSDPSSSHSYAELPDSTQASPPLTLTNGFYTDQELTGVTITAAPGVPGISAVLVMTGIPEKPLALTPSQQLVPSGNQSNSAPVSVSLIPSPVEGLLLSSSQSLEVAMEAAPGSTSGPVTFDPDSFLNSPREGQTYGGASGTAEFKTESSEGGEADREAQEEGCMESVEQKSLVKEEKPNMQKEVLVVEDHREEEESSGLEVEMDTREEQDESRQEEVAEAPGDGQEEDKPDGTHMRDLYSIIHNDLSSSSGASSDHMELSAENFNISFDSQFPDLISDLMTEEAPPGDYEHYGAPQAQSSPAQAQYVQQQVQPIAASASVVGTVFSDGREETPSLVGITDFSPEWSYPEGGVKILITGPWVENTDSYSCVFDQLTVPASLIQSGVLRCYCPAHEAGLVTLQVIHQQQVISHSVVFEYRARNFLTLPSTQLDWLSLDDSQFRMSILERLEQMERRMANMSSGQAQQTSGSRRGESTKMSSADSFEARLVAVCEKMMSQSCWVTSDLLMHEMSFRGMTLLHLAAAQGYAQLIHTLIQWRNLHSQSLPVELEVDPLNVDHFSCTPLMWACALGHTEAASLLFRWDCRALSIPDSLGRFPLGVARYRGHTKLAATLEEMQRMEPFHSNYTRLQGSSWHQLTGSQEFSMGLSPLSTDTGLSSLSSPSQVSDGSVSVTSAYSSSSALQDSPDCSPESSQDTPAETSPSSRILASSWDPEDAGGTALYLDFPGVGDNYEEPHDLLGYTEDTENQGYLQVDMVTLAEQIIEATPDRIKQEDFTASDSAPLKERSGNLSKTMTWLASYLETADQMPGLPPHGEGMRAARALARFAQMSPREEGSSRLSASEMYSQWSKRGNRRCSEALRVKISRSEAPLSPSSPSPLGEIPFERFDPPGAARWSEFLGASSSGRMESEFALLTLSDHEQRELYEAARVIQTAFRKYKGRRLKEQQDLAAAVIQRCYRKYKQLTWIALKYALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQQCYRSYREGARGGSALQHCIKGSFLTKKQDQAARKIMRFLRRCRHRMKEMKQTQECLQTRGLTN
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
GAVSVAQRQGLGVTALHPVGPLRRPGAPLAGGFAVAWAPRCFPLSPQTRRSSVARDPASGDTGRAFTEPGARDAAWPGRPRRAPRRGPSPRLSGTGCAPAAGAPQQDPESASLLTAKFCCCSVPCLDLSLYHLSAGSAGMKEGMSNNSTTSISQARKAVEQLKMEACMDRVKVSQAASDLLAYCEAHVREDPLIIPVPASENPFREKKFFCTIL
The following text describes a protein:
Function:
Flavodoxin-like protein (FLP) that plays a role in cell wall integrity, oxidative stress protection and virulence. FLPs act as NAD(P)H quinone oxidoreductases. Reduces ubiquinone (coenzyme Q), enabling it to serve as an antioxidant in the membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MKIAIIQYSTYGHITQLAKAVQKGVADAGYKADIFQVPETLPQEVLDKMHAPAKPTDIPIATNDTLTEYDAFLFGVPTRYGTAPAQFFEFWGATGGLWANGSLAGKPAGVFVSTSGQGGGQETTVRNFLNFLAHHGMPYIPLGYANAFALQSSMEEVHGGSPYGAGTFANVDGSRQPSTLELEIAEKQGEAFVKSATKLVKGSKKTNTTTTSKSAATSDAAGTTSGTAAGTSAATGAATGTSAPKESTKEASSSAKKEATNGTATRTQQSTKAPETAEKSSCSKCIIM
The following text describes a protein:
Function:
Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAPQGDDTVFQPKDAIKSGVSGALFSGGAGLLMASLRTSMKKNNVGSMHVFTHGGGTIISFTLAGGIYRFAQQASANLREKEDGWNHAIGAFLGGSVMGLRSLRFPVILGFGAMAGSVVGAFAFSGGLTGWGRDPNVDEFERKEAMRLNRRRPVEETLAEVGEGRGIYPPGYQERRRQRLLEKYGVEVKPVSADPNVASA
The following text describes a protein:
Function:
May be involved in free fatty acids export from the plastids.
Miscellaneous:
MISCELLANEOUS: For all TMEM14 proteins, 4 hydrophobic alpha-helical domains are predicted. However, NMR structure determination of the human TMEM14A showed that only 3 of these helices are membrane-spaning while the amphiphilic N-terminal helix is probably located at the lipid micelle-water interface.
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MMSIPMELMSIRNPNSTLLYRAHSRPPVKLCAPPRSLLPSRRHFSAPRAVVSYPGIRFGFTSPEVLLNRSVVAFAASHEDSGESGVEVGKEKSDIDVEDDTSKEAWKQTLESFKEQVSKMQSVSSEAYSVNSQKAMTVLKETSEQLRIQAEKAKEELGTKAKVVSEEGREYILKAAEESPSDVKEIVEAFASTEDLKNVSRANDFHVGIPYGLLLLVGGFINFMVSGSIPAIRFGVILGGALFALSLASLKSHRKGESSTKFLKGQMAIVAIIFLRELRLLLSQKSTFLGFFTTLTSGGVLGFYLYKMVVKREKGPTLEDGGEDESSDGFVRSEG
The following text describes a protein:
Function:
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS to produce anthranilate.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MACSHLAAASSSPATTAAALRARATSPAAGFARLPATLHPENGGLALRGRRAVTPVVAAAGPAAAAPVADRDGTPAAVKQPIIVIDNYDSFTYNLCQYMGELGLDFEVYRNDELTIEEVKRMKPRGILISPGPGEPQDSGISLQTVLELGPTIPIFGVCMGLQCIGEAFGGKIIRVPSGVMHGKSSPVYYDEVLGKSIFEGLSNPFTAARYHSLVIEEESFPHDELEVTAWTEDGLVMAARHKKYTHIQGVQFHPESIITPEGKRIILNFARYVEEFEKQTSEGK
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MAQKMIEDDCEKVYVAISPIQSLCPPMLLWTLRNTPPGKTYSCCSAQTRLPAGFYTQEARTGEKMLRDYLHVCESQKFHAEVLTAEKENVELGLVELVSELKITTLIMGGGLYRERRITISTSTKNGFAPVEVSDFPTSSYHFLGWHPNDYASRSSISLSLLSETQSMTDDGCDSEQLDLMLEYLHPGFDNDSFRIVSKESLIYLDKIANQSTQSGHAQDLHQAPFDDRCHCHFIPDMDRILGIQSRNDDEARWRNCIKHKMTEWLHELRYVCTIVLSAHKQLMQWHLAVHDSLALDKLSKAVKEPITQLLTFASTVSKMHGSPEKFFHMLHMHQALTEAYPVLQEVFSGELKESFTGELHKILHTLKDGTKETLDQLRVQIQSYSSEDMPEGGGIHLVTTYLIRYIMSLTQNTGSLDAILAHSYEDHALAEERMMNTSGHLISMLISDLTSMLYRLSKLYMSKSEGLQWLFLLNNEHFILRKIEEADIRSMLPADWIQNYQHRVEQNKVNYIEATWALTLSYLKKGPKVPSISFILQP