lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop.
Subcellular Localization:
Host nucleus matrix. Note=Associated with the nuclear matrix.
Sequence:
MDKDRPGPPALDDNMEEEVPSTSVVQEQVSAGDWENVLIELSDSSSEKEAEDAHLEPAQKGTKRKRVDHDAGGSAPARPMLPPQPDLPGREAILRRFPLDLRTLLQAIGAAATRIDTRAIDQFFGSQISNTEMYIMYAMAIRQAIRDRRRNPASRRDQAKWRLQTLAAGWPMGYQAYSSWMYSYTDHQTTPTFVHLQATLGCTGGRRCHVTFSAGTFKLPRCTPGDRQWLYVQSSVGNIVQSCNPRYSIFFDYMAIHRSLTKIWEEVLTPDQRVSFMEFLGFLQRTDLSYIKSFVSDALGTTSIQTPWIDDNPSTETAQAWNAGFLRGRAYGIDLLRTEGEHVEGATGETREESEDTESDGDDEDLPCIVSRGGPKVKRPPIFIRRLHRLLLMRAGKRTEQGKEVLEKARGSTYGTPRPPVPKPRPEVPQSDETATSHGSAQVPEPPTIHLAAQGMAYPLHEQHGMAPCPVAQAPPTPLPPVSPGDQLPGVFSDGRVACAPVPAPAGPIVRPWEPSLTQAAGQAFAPVRPQHMPVEPVPVPTVALERPVYPKPVRPAPPKIAMQGPGETSGIRRARERWRPAPWTPNPPRSPSQMSVRDRLARLRAEAQVKQASVEVQPPQLTQVSPQQPMEGPLVPEQQMFPGAPFSQVADVVRAPGVPAMQPQYFDLPLIQPISQGAPVAPLRASMGPVPPVPATQPQYFDIPLTEPINQGASAAHFLPQQPMEGPLVPEQWMFPGAALSQSVRPGVAQSQYFDLPLTQPINHGAPAAHFLHQPPMEGPWVPEQWMFQGAPPSQGTDVVQHQLDALGYTLHGLNHPGVPVSPAVNQYHLSQAAFGLPIDEDESGEGSDTSEPCEALDLSIHGRPCPQAPEWPVQEEGGQDATEVLDLSIHGRPRPRTPEWPVQGEGGQNVTGPETRRVVVSAVVHMCQDDEFPDLQDPPDEA
The following text describes a protein:
Function:
Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Plays a role in regulating the expression of other pair-rule genes such as eve, ftz, and H.
Subcellular Localization:
Nucleus.
Sequence:
MDRRALKFMQKRADTESDTTTPVSTTASQGISASAILAGGTLPLKDNSNIREKPLHHNYNHNNNNSSQHSHSHQQQQQQQVGGKQLERPLKCLETLAQKAGITFDEKYDVASPPHPGIAQQQATSGTGPATGSGSVTPTSHRHGTPPTGRRQTHTPSTPNRPSAPSTPNTNCNSIARHTSLTLEKAQNPGQQVAATTTVPLQISPEQLQQFYASNPYAIQVKQEFPTHTTSGSGTELKHATNIMEVQQQLQLQQQLSEANGGGAASAGAGGAASPANSQQSQQQQHSTAISTMSPMQLAAATGGVGGDWTQGRTVQLMQPSTSFLYPQMIVSGNLLHPGGLGQQPIQVITAGKPFQGNGPQMLTTTTQNAKQMIGGQAGFAGGNYATCIPTNHNQSPQTVLFSPMNVISPQQQQNLLQSMAAAAQQQQLTQQQQQFNQQQQQQLTQQQQQLTAALAKVGVDAQGKLAQKVVQKVTTTSSAVQAATGPGSTGSTQTQQVQQVQQQQQQTTQTTQQCVQVSQSTLPVGVGGQSVQTAQLLNAGQAQQMQIPWFLQNAAGLQPFGPNQIILRNQPDGTQGMFIQQQPATQTLQTQQNQIIQCNVTQTPTKARTQLDALAPKQQQQQQQVGTTNQTQQQQLAVATAQLQQQQQQLTAAALQRPGAPVMPHNGTQVRPASSVSTQTAQNQSLLKAKMRNKQQPVRPALATLKTEIGQVAGQNKVVGHLTTVQQQQQATNLQQVVNAAGNKMVVMSTTGTPITLQNGQTLHAATAAGVDKQQQQLQLFQKQQILQQQQMLQQQIAAIQMQQQQAAVQAQQQQQQQVSQQQQVNAQQQQAVAQQQQAVAQAQQQQREQQQQVAQAQAQHQQALANATQQILQVAPNQFITSHQQQQQQQLHNQLIQQQLQQQAQAQVQAQVQAQAQQQQQQREQQQNIIQQIVVQQSGATSQQTSQQQQHHQSGQLQLSSVPFSVSSSTTPAGIATSSALQAALSASGAIFQTAKPGTCSSSSPTSSVVTITNQSSTPLVTSSTVASIQQAQTQSAQVHQHQQLISATIAGGTQQQPQGPPSLTPTTNPILAMTSMMNATVGHLSTAPPVTVSVTSTAVTSSPGQLVLLSTASSGGGGSIPATPTKETPSKGPTATLVPIGSPKTPVSGKDTCTTPKSSTPATVSASVEASSSTGEALSNGDASDRSSTPSKGATTPTSKQSNAAVQPPSSTTPNSVSGKEEPKLATCGSLTSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSGTFITSCTSTTTTTTSSISNGSKDLPKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRYADKDVSDEPPKKKATMQEDIKLSGIASAPGSDMVACEQCGKMEHKAKLKRKRYCSPGCSRQAKNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDEAMAEEKMQTEATPKLSESFPILGASTEVPPMSLPVQAAISAPSPLAMPLGSPLSVALPTLAPLSVVTSGAAPKSSEVNGTDRPPISSWSVDDVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKEKHLVNAMGMKLGPALKIVAKVESIKEVPPPGEAKDPGAQ
The following text describes a protein:
Function:
Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
Subcellular Localization:
Nucleus.
Sequence:
MVLGFILDPKSHLGVQTLLQQIQDKFQTMSDQIFGRIDDMSILIDNLEGNLTNFLMKEQKVKNKIAILQELKCANLH
The following text describes a protein:
Function:
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Subcellular Localization:
Cytoplasm.
Domain:
Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex; The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.
Sequence:
MADWSEHAHYGNPNGPMGLPPAVTALTFDPYHELLWQGTSFGTVSSLYSAQLSRYTSYAAHGVPTRPSPTKNILADERHIFSLSDNGIKCSQRRGLAKWSTLTDDLGTNAMNLVSMCASPLAASSDIVAAGLSQSAASTGEIDNENDLIVTVNNSTGAVVRTVPSEAPIVHVRKSGRFVCAGTATGHIQLRDPRTLKVEHRLHAHPGGLVDVQADAHILYSVGWTVRQGHPVSEPLVKVHDLRTMRALVPIPFAAPGGPSLLAIHPKLSSTIIVSAPQGQFQIVDIGMPGEGRFFYTNANSFTTSLAISPSADYIAFGEADGSVRLWSSSSDTSNLRFNTFVSSSLEFPDMVEPTPFVNWSTETPLSSIGMPHYNQKLMSFFDYDQYVSEASPLFNPPSKIDPAVLNNIKTVDYLGYANLPPHFRGKRNTVSGKGPGGIRASALHRPEDRKKIGIPLFRSEKEKEQSKKAAAAAADKKKKKAERKRADAGSDSLNTSTDSRLERRADQDAGSASRTQAGSSKLANRDDSPTDNASQDAQNFADGSDANSDYISDDSEASDDEEEGQEDVETAEAMLVKGQMPSYYRLKTIQYSRFGVEDFDFDFYNKTQYSGLETHIQNSYANSYLQALHYLTPFRETAKAHILHDCPRENCLLCEAGFLFRMLEDAKGANCQASNFLRAFGNSHKAVSLGLMDREDSSTNMSSAASAGKNEIVYSQLVQTLNRFVLDETANEAQVSPGGSSARNATGSNSGSTRASGTGAPPGLGPPLSSNRGGGGAGRRLAGDSSPSTSLLPADNPAFAADSPVAKLFALNAVTKTVCIHCGRETNRPTPLLSVDLIYPRRSMSNESAPPSDFASVLRASLVREVQNRAPCRACQFTAMFRTRRVMPATSELPRILSVNASIQAPEHLHYWLDDNQKGGNKAPPLGPARPNGPQQQAYSKLAYMSMHGSNAHNNARGGAGGGLLNAPRTDTKLASAASAGDAKRTYLPPRIAIGVYGDDVRVMPIYTAADVERARTSLGGRPAMYKLRSMVVQISADKEQPHLCAFVRVPEAETSVQGSNGDGTASTAATTPKMSHATGAAAGLALGSSKKSARAKANQLGPWYLFNDFLVRNVSKHEALGFQNTWKMPSVLMWEREDLEPLCIATLRQGRTSIDPLILCRDFNISQNRDPTRIRHTLLSEDELPKPGTLVAIDAEFVALNQEELEIRSDGTRSVIRPTKLSLARVSVVRGQGAKEGISFIDDHIYTQEQVVDYLTKFSGILPGDLDPHTSKHTVVPLKSAYKKLRLLVDRGCIFIGHGLKKDFRIINIFVPKEQVIDTVDLYHSVNHPRRLSLRFLSWFLLKIDIQSGANANNQITAREESSKASKEANEAESAVERVASAEKGAGIVAVEGGHDSIEDALAALKLFRLYEVFKRDARLDDVLEDAYDVGRRVNWKPPNAV
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MRTPINVRNVDIVIRVRIVYDGIGRMRGISDAGAGPGPGTAEAQGRANALHSKPVKGFYDHEKVRRMWLKEEEEGSMNAPSTSMPSAIPKKPDITTKAYIGPSKPILPRRNTQNGADLRAPGPYTHRPYCLGPAKPRVGYPNRKPIPIREIPVQKVEPDLDWSILDRLNRSIRSPTADDLNIPMHSRSPNPLTDDWNLLEAVASSEGPSEDATTSITLESSVERNCTSPTAEFPVYDFLEGFDEFLNTKNLENSKISNVDLKNSQKSSPTNIAEALQNVFANTYQTSSFSRNLPQRYTQRAAREKDRFPVNCNRVSPIDGSDDVAEDDGKPVPVNPRQFVRILRRREMRARQEDSGVIPVERQAYLYESRHQHALSRVRLSDGRFDPAARKNSGQPPTSEIVPTQPTLKRQYTPIRPAHSDQDPLPKPSEMYRTKGPQVPRLPTASIRAPVPGPSIVAQLRPTGNTRAPIQTAPRGTANIEIREESSEFLDSLNMLASEVTTTTLPESLESLLSGILEDFSQD
The following text describes a protein:
Function:
Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
Subcellular Localization:
Golgi apparatus, cis-Golgi network.
Sequence:
KPKRASYEWYHPKGILKRNWMLKHLHVLPSVVVLFQDMEWNDLQWTEKQVQCAAIVQALKNALQERNTRLCLVLLQRAAPLPPGEDLLAAERAASLTNACGITSKMLFILPHTEHLTGYALRLESAFLDMAQSYYALMSKRIRNHRDQLTSAHTSLKIRHQFKLGFVAEMRQDFSTGQKHYFQAYANLDEIRINDGNCLEIKTLAGFLNYKICRLMFKLKTPRDAINQFIIHVEKHKSRVGFKDLAFEHHAWLSTQHSVFAELFCEAIKNGLPALQTQHPGIYYHKAAEFVMKRRDAAMEAYAAMQASSEATPTPIQNPLSLYTEFFGIRAVKTGDLVAEQQANMQLCDQERSYNHSAAIIALLSQAMAQFKIYKCLRFRKKLAIDMAEEYLKSGDHAKALTLYSLMLPDYRQEKWTTIFTDVLLKTLRCALLSGSVADYIACSVEALSLRHQSDQSERILILENLWQVFQGVPPMPKTQLTPEAQALWTSALANVKSPIQIDLDKVNDVVEMCATFERVQLSNDDLLQLQLIVRVLTDIPLRIRSFHVILADAGNPQNSYKLEALKYFCFPTLTQLRGQKQPDNEQLENQSQEPKNFEKNMRLEPGSYYQLFCSTEAQQFHENTQLRIVRLEAHMGTDQVAALLTCSSNYSRQLFRHHTRSRDLDDNVTINPICYIAPTFHLDTQTNLGHGHDNGLTDDKEMVATKMLVNEYFPVVTTVSNPYNVYLQNVGVHISIPVGLRNSVFLTTDISPGRQKLHSQIQIDVGELSAHGSNTATFYIFSLTEAEIKLAQRLSYTLDVDRGPGGGGSNARVSTAPNSSESTPDHEVKSVIPSVAAISPVQIEYLDETRLRKSREDTLTVRCYGDFKFNARFYTMDRKPLNQVYRGENFLLRANTEVVAVDDVEILDSFFICDHNLVQSNYSFKQKKYTNKYSAGEQLESVIVLRTNATLRDWATARDLDHRGKLEGKAVASKFIRPVPKPSSEEPLAPTPPAGISAYMSKSLVTKIPTTMTIINSNSAVSNALQVANAGVMSNSTQSDDVNVAEEAINTQEGIKTTRLIYNKALEAVQGTGHCRGFIKKIYTLEGNPSAVPIFGVFCIRWRRANCKEENESKFVIRGLDIAEPPLNIYCTIEEKMFVKMPMAFKVVLKNPTTHVLHLIANLSISKTDNFICSGHKQLDISIMAYEEKELVYNLYPLQVGWQELPVLSLEYNTKADPQKKDSQNALLDELVQRALPKRVFVLPPLKQQNK
The following text describes a protein:
Function:
Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient. May also transport beta-alanine. Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake.
Subcellular Localization:
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Presynapse.
Sequence:
AKARLASFFCSCWSPASSDSPGIGPITLLSPPHHLPMKSSFICVLLLSCLTGIFVLGLPFALVRSGYVGLVLLALSAWVCNHTGRILVSCLYEEEVRVRQSYQDITEACCKGLWPGWEGVGGWMVNVAQLIELLMTCTLYLLVSTNLLSDCLSAAALHRSVCSLLCLLLLLPCLLLTDLRPVSVLSLLCSLAHGLISLLVMLFCLSCASNWYWSSLSLAVDPENFLVSVGVIIFSYTSQIFLPSLEGSMEDRGQFDTMLGRTHGAACIMKTLFALLAALTWGSETSEVVTDNLPPNLRPVVNMCLLAKALLSYPLPFYAAAEILQSCFLRGRGVSRPALMTRCTLLLTSYFLALLVPRFSLLMGLTGSVTGAALTLILPCLFHLRLQWLRLTVRDRLTDVCILSLGVMCSVSGVICAMKRLVEGS
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway. May cleave double-stranded RNA to produce short 21-24 nucleotides (nt) RNAs which target the selective destruction of complementary RNAs (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGGPLTAAGGRGDGGAKAVEPLRPPPPPDPKTMARWYQLEALERAVRGNTLAFLETGSGKTLIAVMLLRAYAHRVRRPDSRRFAVFLVPTVVLVGQQARVVEQHTDLVVKQFCGEMGVDFWDAATWRSQLEDGEVLVMTPQILLDNLRHSFFRLQDIALLIFDECHHARGNTPYACIFKEFYHPQLNSSASDPLPRIFGMSASLIYSKDLNQHNYSKQISEIENLMNSKVYTVDSESALSEYIPFASTKIVHFDDSNISSELHANILSCLNRLTKKHIEALDRKLHGSSLENAKQRISKLHRTFVYCLYNLGVWLAAKAAEVQSYEENSLSFWGETLDKNVEGFIRNYSEEVHRELSCFLKNGHIGEKFPADSQDGILTPKVHCLIRTLLQYRHMQDLRCIVFVQRVITSIVLEPLLSSIHQMSGWNVKHMAGSRPGLLSQSRKNHTEIVESFRKGKVHIIIATQILEEGLDVPSCNLVIRFDPSATVCSFIQSRGRARMENSDYLLLVGRGDVEAHTNAKKFLASGQIMREESLRLGSISCQPLENTLCEDTYYRVESTPAFDIDKASGTCTLHLPKSSPVQTVNVEGEGSILKETVCLKACQELHAIGALTDSLLPELDVPCDEEPDIVVENKIEQPSYFPEEFVDNWRSFSRLGIYYCYKISLEGCPKTASPTDILLALKCDLGSDFTSSSFKLPGGQDNASVTMKYVGIIHLNQEQVIIARRFQTTILSFLIGDDHLEVSNGIKYFHEMQVPIGVVYLLLPLVSGRIDWCSMKFSSSPIYEANNKHMTHCHSCRDIDLLQTKDGPFCRCILKNSIVCTPHNNIFYVISGFLDLDANSRLPQHDGTVVTYKDYFKTRHGLTLTFENQPLLAGSKHVKVRNFLHNYYYKKEKEPGDRYSVELPPELCRIIMSPVSANNLHIFSYVPSIMFRIQCMLLSVKLKVQLGPTVQQFDVPVLKILEALTTKKCQEEFSQESLETLGDSFLKYVTTRHLFSEYRLQHEGILTKMKKNLISNAALCQLACSSNLVGYIHAEEFNPRDWIIPCLDYDERGNKKISFLAPNGMYSQRKMSIKSKRIADSVEALIGAYLSTAGEKAAFLLMKSLGMNIEFHTEIPVERKISMKAEEFIDVRSLEGMLGYKFNDSLLLLEALTHGSYQTSGPTSCYQRLEFLGDAILDHLFTEYYYSKYPDCTPELLTDLRSASVNNNCYAHAAVKSGLNKHILHSSSELHRKMSYYLGQSFTGPSYGWEAGIGLPKVLGDVIESIAGAIYLDSKCDKEVVWRSMKRLLEPLATPETIEPDPVKGLQEFCDRRSFKITYEKNHVDGVSSVIARVKAGETTYSATKSGPCKLAKKLASKAVLKDLIAGHKDTEAAAV
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Chromosome, telomere. Nucleus.
Sequence:
MSGDSSGRGPEGRSRGRNPHRDRTRSRSRSRSPLSPRSRRGSARERREAPERPSLEDTEPSDSGDEMMDPASLEAEADQGLCRQIRHQYRALINSVQQNREDILNAGDKLTEVLEEANTLFNEVSRAREAVLDAHFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEELIHDEDSPDFEFIVYDSWKITGRTAENTFNKTHTFHFLLGSIYGECPVPKPRVDRPRKVTVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQTYFREDPDTPMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIEPVSINEENEGFEHNTQVRNQGIIALSYRDWEEIVKTFEISEPVITPSQRQQKPSA
The following text describes a protein:
Function:
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRRLRRSRVLFFISGVLLCFVYTLTLKAKLSQLPASAGADRGHHEVLEVRVRELLQAPNETEATAPESTQPPLLIVVNRTDIEQCVYVDPLPPKPPPTTPPVTTSPPSHPPGLPPHRKGDYPEDLFSIEQRRQGWVVLHILGMVYIFVALAIVCDEFFVPALEVIAIKLDISDDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGMCAIFSREMLRLTWWPLFRDVTFYILDLIMLIIFFLDNVILWWESVLLVLGYVSYVSFMKFNPQIEQMFKGQLNKHTSIVKVWSAEEPEKESEAAPLPPPSSPPPLPPPAAAAPPKAQEKPKAEGERPPSSAHCNSLQTDAQQDKTRLRVRPVLQRGGSSASLHNTSLRNTIFQLMIHTLDPLGEEAALRGTARSTPLKKVRGEASFNGDVRGGKPVQRKAKNKVKPLNVPPTEKLKNKFDQNQTEDGDQKPKCDVDGPPGGEASSSQPEKSEEQKKTSDDADESKVTTATEGGSEGSDGSSEEESGNKESSEPSDSDEDGEKDAEENEEEEREPLSLEWPDTPWKRATYLFLLPILLPLWFTLPDVRNATSRRFFAITFLGSIFWIGIFSYMMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPIPWLLFTALHNGDPVVVSSNGLFCAIVLLFLMLLFVIISIAACRWKMSKMLGLTMFVLYFVFLVLSVLLEDRILTCPISI
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MCISSRIRSLLVLLIVLFPISIYAQEVQDEREFDYDKASGKGPEKWGKIHKEWSACNNGKMQSPIDLSNKRVDVVHKSKKLLRNYKPSTAVIINRGHDIEVHWEGHAGSIKINGTIYALKQAHWHSPSEHTINKKRYSLELHMVHKSVDPTSKHQIAVIAILYKIGKPNRFLSKLARNITSLVNQENEHRHPGVIDPREIHMSCRRYYNYIGSLTVPPCTEGVIWTISKKVRTVSLDQVKLLREAVHDHAAKNARPLQPDHKRGIQLIGP
The following text describes a protein:
Function:
Transcriptional activator of drug-responsive genes including the ABC-type transporters CDR1 and CDR2, as well as HSP12 and RTA3. Binds the cis-acting regulatory drug-responsive elements (DREs) with the consensus sequence 5'-CGGAWATCGGATATTTTTTT-3' in the promoters of target genes.
Subcellular Localization:
Nucleus.
Sequence:
MDTSSSSGTHPSTFNNLTKQQELTGNDPNDTNRKRIRVACDSCRRKKIKCNGSYPCGNCIQAKNTSNCHFTERPVRKKLKPTKQDNKSTANSNGVSKRKYNDTFSGNSINIKTEKQENTTFGINDNKSSDLESRLSRIENSMSRMMHTLENFSQNFMTQAIRNNHSNSSMFNNNSLSPTPSEDFNKSAFDSEEQQTSHSYKNLKDRVKDANELLKLRNWDEFVGTHSITCIFSRESLDWMEKTLGSYGEEYLTPIRNLPLVFHSELKPYIMKWIDPPVVDKLQRKKLLESPFPTDSKLISKLIDLYYEETSMINILVDESRVRSLFAAYYNNFAEPIATKRRRFKLSELLLMTSILLISLSCLTEDDFSEERITTPASSTSSNYSAASANLLGDYNKNRLIALQNSLENSAIFYYHRISVISEGLETVEALLMFIIYVESNWLTSFFNYTIITVTIRFAQEIGLHRAETYNNLDLEEATKRRKIWWFCYFFDIEFSFKSGKPPVINTNDVTTNSDEDLLRVITQLKQYGPLSPKDRMYSPVCHTISTSLLDLSGSDSICLDILKIIQSGDILDDPFYFQFCALLQSRIRSNSYHDLFIASAEKRDFSSISNTLEKLNADMFELAMYLADEAKPRFYNDPKFTSVQASTGTSIRRDTILAMKLTFFSHLMIINRYPLMIATEDSKFDDRVIKFRNLSLDSARTILMLIKGWHRESASALFYNWAIYFPVAAYLVLVAAIINHPQLPESGTNLNLLIETSLSFFKSSKQWNSSNDSQDKQQNSTICVNKIVAIELIVRLMLRVVIKVYELHNNVEILANNPALQNHLQEAEEKFPDIFQNHAEFTSKMIALVGASPFGGCGSRNTSSCNLRDNSTNHGQNNMNPSPTITNNTYNSNINTGSNSTGEPQVCYAQSPSYNASLSNIINNESTGRSPATSTSINQSMMNENYDLFNDYLIDNSAVNLPFSQFNNLPNFFFDNNLGI
The following text describes a protein:
Function:
E3 ubiquitin ligase which accepts ubiquitin and transfers it to substrates thereby promoting their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway which is a pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. May regulate the unfolded protein response to reduce endoplasmic reticulum stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAAVLEVEIGGEAVREAAGEELDLSELAPEERWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHQRSYNMVTLFQMWIVPVYFTVKLQWWRFLGIWFLFSIVTAYITYKATRKPLELTTPRLVYKWFLLLYKMSYATGIVGYIAVMFTLFGLNLLFRIKPEDAMDFGISLLFYGLYYGVLGRDFAEMCADYMASTIGFYSASGMPTKHLSDSVCAVCGQQIFVDVNEEGIIENTFRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGLVQGINYCLGLE
The following text describes a protein:
Function:
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
Subcellular Localization:
Cytoplasm. Note=May associate with membranes.
Sequence:
MRAIGVIRNSRRERLSRAEFEELLRSAGYEVLAIVEQNREEHPRYNIGPGKLEELKELVKELKPDKVIFANRLTPSQAYNLWKELRIEIMDRWQLVLEIFEKRAHSKEAKLQVELASLQYEIPLVKEAIRRIRLGDRAGFKGMGEYQTQQYLKHIRYRMGKIRDELERVKADREVKRKKRENAGFVLVALAGYTNAGKSTLLNALADENVEAKNQMFTTLDTTTRRFRLGTKRILATDTVGFIDGLPPFIVEAFHSTLEEIVKADIVLLVLDSSEPWGEIRRKFLASLQVLRELKALEKPIIVALNKIDLIEEADAEEKVRLIWELARERGISLEDVVKISAREGRLEELMDALNRVVLKLPKYGAFRIIVKEPEKVPAVMALINSVGEVLSVEYGEKTRIDAYVQTGMVGEIKKMGAEIERLNHSGEGEELEQDEGYSDGG
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in eye morphogenesis, probably triggers the ubiquitin-mediated degradation of different substrates. May play a role in the regulation of the cellular clock function (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The RING-type zinc finger domain is essential for ubiquitin ligase activity; The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family.
Sequence:
MSRPSSAGPCASKPCGKQKQPPPPPPHAPSLPATISGGPGASAPPAPTAAAITGPLSQQHQELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRASLTPSIRNLAMEKVASAVLFPCKYASTGCSLSLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLENVMQHLTHSHKSITTLQGEDIVFLATDINLPGAVDWVMMQYCFNHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENYAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCP
The following text describes a protein:
Function:
Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MEENKQDGEKKEESSSGPSNESVLKEAKEVAQEGAKEEKTVSKEVDAALKALKEDAKLAASTAADKADPSSPEHIKKKEEEKAEKAEIHDTGVIETTEKERLLYFDNVIMATPSFMLGDHFPSWLLNRSEERVKDVIRKYAIPPGLRVDFNSVILRPKDGGAFVRYTLREHTGKYGTPREAEAAIINQLKKSDYRPWFDPFRTCRVFTVKGVPWIEDLKRIPNKTLKIWFEGPTLSQEELYSLFRRYGYIDNIVPPDAASKDPIVFAKVIYSCKGSSTTAKNCLNGMSVNDKTILHITFADHRTKLSYLKDFIVNHTRISIPILLALLATVSLWIFDPIRKESIKSKIQPIINLDNNIFYVQTKNILKPIWSWLWSWIVIHPRPTAKKAGTQLHQLWPERLSAIEDVKQWLQENVNTFIVVNGPRGSGKQELVMDYVLADRKTNGGGRGKILSIDCADLVKARNDPEFITTAAHQLGYFPVFPWMNNISSFIDLAIQGLTGQKGGFSETTEAQFKSMLGIASAAIADIALSNHNKEDHAKNQITRNSDYLQSHPDAKPVVVIEHFLARTDRNQFVYKHLAEWAASLIQSNTAHVIFITSDVTFQKVLSAALPNQIFKTVHAGDASAQSARDFVKQQMDEFKKAIEAARHLVEENKHQKERVEALVDEEPSLEEMLQHHRTELEYEREKREREGKIDDTLDEIIKEEKVIEERDRAEWDATSAAQREDEKVSPFDPDESTAGVEAEKEENKTDGDGEPATKDNGKSDEQNKNDTITSWKALIPPGTDEATLAEIPIPDLTDLDEALSPLGGRMTDLQAFIRRLKSGDTPREALRGMITQSATEIVQMFLMKDNAQWTKEQVWCLMKKVCKDSGNGVSIADLMVTEPMFKGALKPQGESGESTIGALERSEMVTVVTRDGKPTYIKAGKPLYRAAFQYILSDKTFSAMIETGFLESQMKLQNDKIVKYEEELRLLAKFPSKWGDDVNIRVRYLIDKMAACQQKIQKFEIQLAETKKTFAKNEQPKSWWKW
The following text describes a protein:
Function:
Transcriptional repressor of the maltosaccharide utilization operon malEFG.
Sequence:
MTTRLADIAAQAGVSEATVSRVLNGKPGVAATTRQSVLAALDVLGYERPVRLRQRSEGLVGLITPELENPIFPALAQVIGQALTRQGYTPVLATQTPGGSTEDELTEMLVDRGVAGIIYVSGLHADTTADMQRYERLRAQGVPFVLVDGFSSQVQAPFISPDDRAAMSLAVTHLVSLGHTRIGLALGPKRFVPVQRKIEGFVRTVQDQLGLSAETVEKELVQHSLYTLEGGQAAASALIGRDCTAVVCASDMMALGAIRAARQLGLDVPKDVSVVGFDDSPLIAFTDPPLTTVRKPVPAMGQAAVRTLLEEIGGTPAPHSEFVFMPELVVRGSTASAPGERGRP
The following text describes a protein:
Function:
Scaffolding protein involved in the icosahedric procapsid assembly. Coassembles with the capsid proteins to form the procapsid. The scaffolding protein is found within the capsid as a serie of concentric shells. During DNA packaging, the scaffolding protein molecules are released from the procapsid.
Subcellular Localization:
Note=Present in about 147 copies in the prohead but not present in mature virions.
Sequence:
MPLKPEEHEDILNKLLDPELAQSERTEALQQLRVNYGSFVSEYNDLTKSHEKLAAEKDDLIVSNSKLFRQIGLTDKQEEDHKKADISETITIEDLEAK
The following text describes a protein:
Function:
Component of a CST-like subcomplex of the holoenzyme telomerase ribonucleoprotein complex, which stimulates telomerase complementary-strand synthesis. Telomerase is an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER. The CST-like subcomplex (also named 7-4-1) binds telomeric single-stranded DNA and coordinates telomere G-strand and C-strand synthesis.
Subcellular Localization:
Chromosome, telomere.
Sequence:
MEDNFELVFLKELPSLPDFSKVCFTGLILSFSNFPSSEQNQQKDVPHKIAIIQDSTGEAELFLDMYKFCQEEISVFKAITGIGVLKKKNIGAGQVCKIIVERFRIIHSADEEMLQYLLIQKYKLSKTLNEQQQIKQKEQQINQQKIDKVVQDKESKEHLLWKQQQIPQIKSNQENINTLKYKELIAGELMRITHKLLIQKLQQQQPANNNKQINEMDVESNELAEKKEVIIKIQEIAKDQQLYDTLSIQYQVDQKEQYYAKIAQSLEDFVSISALKMVSYIYPNISYQVSIGFFQNILDIATKTVKDRGALGCNYKYLKDKLTKALNLQQISYPLISESYISYLVHLFQDFNIIEIENEHKFYYKQAFQYDDS
The following text describes a protein:
Function:
Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis.
Sequence:
MHRGAPGPGLGGLKGAEDSAEDLGNACLGARREFGVLRENGQPCGLGEAEETAGGRRRSRPVRSKARRMAANVRERKRILDYNEAFNALRRALRHDLGGKRLSKIATLRRAIHRITALSLVLRASPTPRWPCGHLECHGQAARAGDAGDPGCRPPQPAPLPAGPFAPRCASCFPHAPLGRPTAVAEAQGAAQTSAGSWRRCPGAPSAWPRGHLRAGPGMGYQHS
The following text describes a protein:
Function:
Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MPPKKNGKKNRDQAIKTGGMEETEQKNAEELTESDKKFYQAQIRDLEERLERYQLKCDELEVQEKDLSSKINNVEKEKKDIVLFLKRTLAKKEDKLNDLAETLSRHQQAQEAERESFESQLSLLRRELQENKEKYTSENMTLAGKLASLEEFSTQRETLIAERRSLEEQLRKQKEDHQAEIYNLEKKAVLDNDRLKKEMLQHVATVAAEFRRVSDEKMPETTLRAMQENLSVTAQLQQLSEKTKELLKENDALRARERQLKRENGITEPLLHEITKKSVANQKVVLQLTEKCKQMQSEVEKCTKLKQDHQELLDIHSAVCTEIEDLRKKHAAVTEDLNQTKAEVERQKKELEEESRMRAQINTVLEEAAVALKEALRDVPEEEDSELKVTVRRSQMMQKLLAVLDGAAALGKGPALTDLMTCRPGALQKTSPHLSHYKTGDLGLVPRKTHSTSTKMGNLSRSAYTSLQKKA