lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MSMQVRGLEEQIGVQLFRRTPQKVLLTPEGRILFEQAKRALQEVQSGLDLLTEAAQSRSRHIQMACVPTLATGWLPNILATFKIRHPNTQVQLMELPTGPMLELLRRRDVEFGVGPQIPGMEDFEFEPILEDPLYACVPPVFDEGQSSVCFADLVDKPTIMLSKSTAVRGLIDDTLETLGIHLDVPFEVQQATTAMALAASGLGIAIVPRVALVQAGVQQFRMVPISNHVGLRQVGLITARGPILRPNTERLITLIRTSLAQLR
The following text describes a protein:
Function:
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Sequence:
MTRILKLSHLTPQQLNQLKRRSEQNIDQALAIAKEVIEQVKMEGDAGVLHYSRQFDFAGATAENLRVSEAEFAEAEKLVDPELRRAVEHAFRNIEKVHAGQMPPPMHLAEIEPGVFAGEKITPLPTVGLYVPRGKGAFPSMMLMLAVPARVAGVKKIVVCTPPDKEGKVEPVSLVTARMAGVDEVYKLGGVQALAAIAYGTKTVSKVDKLIGPCSIYGAAAKRLLSGIVDVGLPAGPSESIVLADETTDPKLAALDLLIEAEHGSDSAALLVTHSASLAEKALGYLGEYLEKLPPWRKKFCEDGLGSYGGILLTDSLQASLDFINDYAPEHLQVLTADPLKLVGKIDNAGEILLGNYTPSSAATYAIGVNAVLPTGGFARSYSAVSVFDFLKRSTLAYLTEEGFAGVKETVTTLADYEDFPAHALAIRERENLL
The following text describes a protein:
Function:
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with polytene chromosomes. Associates with the hsp70 promoter when it is inactive, but not when it is activated.
Sequence:
MIMSTPAKNNNGTGLEDVNIPGQAYLREALTSCTDPLKAIESFQLENGVLLPSLRPMLPLLDLHGVRRLDFHTSLMEELRDKLIAHINEMGQKEPRERDKKLKELLVKSFPVVRVKSLRPVVMAILRNTQHIDDKYLKILVRDRELYADTDTEVKRQIWRDNQSLFGDEVSPLLSQYIREKEHILFDHTNLNNLFFHPTPKVRRQGEVVQKLANMIGTSVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLMALHDLEVQEIISIDPCHKFTWCLDACIREKNVDIKRSRELQGFLDNIKRGQEQVLGDLSMTLCDPYAINFLATSAIKILHHLINNEGMPRDNQILILLLRMLALGLSAWVMIDSQDFKEPKLDCQVVTKFLPALMSLMVDDQCRSLHAKLPPDERESALTTIEHSGPAPDAVEAYIQESSVASILAMYYTLHTARLKDRVGVLRVLAILSACKDDRAYEDPFLHSLIALLIPMSEEFATEDFCTTLFDEFIFAGLTRENVTSRHMLKLLWYVHNKLPAGRLATLMKAMQPTTAHNEHIHKLYEILQERIGTGAAETPVIEAPPMEFDSPLKSVPTPGPHYNVQ
The following text describes a protein:
Function:
Required for respiratory growth, stability of the mitochondrial genome and for proper assembly or maintenance of mitochondrial proteins.
Subcellular Localization:
Mitochondrion.
Sequence:
MLKLARPFIPPLSRNNAISSGIVLTSRRFQSSFTFLSNQSLLSKNQMKSKRKKGSKKAAYHRQPPEHEHTAPLIKQNKTITKKEHSDVRGSHLKKKRSDFSWLPRVPSTSHLKQSDMTTNVLYSGYRPLFINPNDPKLKEDTGSTLYEFAMKLEDLNEPLSPWISSATGLEFFSEWENIPSELLKNLKPFHPPKEKSMNTNELIHVSAKRNTLVDNKTSETLQRKMDEFSKRRGKGRKKSVVTLLQMKKKLEG
The following text describes a protein:
Function:
Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol (By similarity).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MISLLQMKFRALLLLLSKVWTCICFMFNRQVRAFIQYQPVKYELFPLSPVSRHRLSLVQRKTLVLDLDETLIHSHHNAMPRNTVKPGTPHDFTVKVTIDRNPVRFFVHKRPHVDYFLDVVSQWYDLVVFTASMEIYGAAVADKLDNGRNILRRRYYRQHCTPDYGSYTKDLSAICSDLNRIFIIDNSPGAYRCFPNNAIPIKSWFSDPMDTALLSLLPMLDALRFTNDVRSVLSRNLHLHRLW
The following text describes a protein:
Function:
Component of the 60S subunit of the ribosome.
Subcellular Localization:
Cytoplasm.
Sequence:
MRQRDSERGIDPRKEKDADLRQDAGRKDHHPGGRQQPHSPRCQGQIQAKEGVWAADQQQRVIFAGKQLEEEEDDGRTLSDYGVQQESTLQLALRLSGGFRGCLYRFEPSLRALAEKHNSNKMICCKCYARLPLRATNCRKKKCGHSNQVELLIFVYSLLPAM
The following text describes a protein:
Function:
Mitochondrial DNA endonuclease involved in intron homing.
Subcellular Localization:
Mitochondrion.
Sequence:
MRIQIEKDQLGWVAGLLDSCGNIMFSKTHVSGNIEIKLKLTDYECLENMKTKYGGAVKVSRTGTRYRLNHSEGLKKLLEDINGQIRIPVRVKKVKEVCEKNNIEIKYPDKELSLDTAWLSGFFDGVGSIVINQTTLENKKQLVLTFNQKNNQILIKIQRIVGGNFYINTNTQSGKYKYALYFTSKEEILQLYEYFKKYPSRAYKNKRIGLIPQYYELQTLMTSIHDNQLQETLWKKFMIQWDYKEIDEIQSGEILKQKGVIR
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKRIGQAYNVYAVFIGMTSYETMGGKFRQSRITRIYCLLINAIFLTLLPSAFWKSAKLLSTADWMPSYMRVTPYIMCTINYAAIAYTLISRCYRDAMLMDLQRIVLEVNREMLRTGKKMNSLLRRMFFLKTFTLTYSCLSYILAVFIYQWKAQNWSNLCNGLLVNISLTILFVNTFFYFTSLWHIARGYDFVNQQLNEIVACQSMDLERKSKELRGLWALHRNLSYTARRINKHYGPQMLAMRFDYFIFSIINACIGTIYSTTDQEPSLEKIFGSLIYWVRSFDFFLNDYICDLVSEYQMQPKFFAPESSMSNELSSYLIYESSTRLDLLVCGLYRVNKRKWLQMVGSIVVHSSMLFQFHLVMRGGL
The following text describes a protein:
Function:
Regulates arginine biosynthesis genes.
Subcellular Localization:
Cytoplasm.
Sequence:
MNKGQRHIKIREIIANKEIETQDELVDILRNEGFNVTQATVSRDIKELHLVKVPLHDGRYKYSLPADQRFNPLQKLKRNLVDSFVKLDTAGHMLVLKTLPGNAHSLGALIDHLEWDEIIGTICGDDTCLIICRTPDDTGVVSDRFLNML
The following text describes a protein:
Function:
Acts as a magnesium transporter; Acts as a plasma-membrane magnesium transporter. Can also mediate the transport of other divalent metal cations in an order of Ba(2+) > Ni(2+) > Co(2+) > Fe(2+) > Mn(2+).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAMESVIEVNQGEGQLTSSLLSSSENSHQLSPETGDLDRASSLTRVCSREPSESDPLLSTAFYGATVNISQDEPHNIQEMPSESIRAMVLQILFPFLLAGFGTVLAGMLLDVVQHWDVFRNVTEIFILVPPLLGLKGNLEMTLASRLSTAVNVGRMNCSREKWNLIKGNLALKQVQATVLGFLAALVASFLEWILKAELITNHVALLCGCSVVTAFTASLLQGILMVGVIIGSKKVGINPDNIATPIAASFGDLITLGLLAVISQGLYYCMEPYPYITYLVCLFFLCLTPMWVILSFHHPESQKLLFSGWEPVITAMVISSLGGLILDRTITNPKLDGLVLYTPVINGVGGNLVSIQASRIATYLHFQCPLGELPEDTKGCYCPCRYFCSKGPNGRSAQVLLTLVAPGHLVFIYTIYIIQGSQSPPTAVFIFFYIIAAFTQVLLLMSIADVMVHCLWRYGRDPDSFSIPYLTALGDLLGTALLALCFFLKSLVT
The following text describes a protein:
Function:
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
Subcellular Localization:
Cytoplasm. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane.
Sequence:
MDEIVQFDFPTDSPKIIKVIGVGGGGGNAVNHMYREGIHDVTFVLCNTDNQALAESPVPVKLQLGRSITQGLGAGNRPERARDAAEESIDDIKEQLNDGTKMVFITAGMGGGTGTGAAPVIARIAKEMDILTVGIVTIPFIFEGEKKIIQALDGVERIAQHVDALLVINNERLREIYADLTFMNAFGKADDTLSIAAKSIAEIITMRGTVNLDFADVKTILKDGGVAIMSTGFGEGENRVTKAIDDALHSPLLNNNDIFNAKKVMLNVSFCPTSELMMEEMNEIHEFMSKFREGVEVIWGVAVDNSLDTKVKITVLATGFGVEDVPGMDTLHEARSQEEEERQLQLEEEKEKNKERIRKAYGESAGIGKKSLRSRRHIYIFNTEDLDNDDIIAMIEESPTYTRDKTKLLKIKTKAALEEEVAMEEATDNDGVITF
The following text describes a protein:
Function:
Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein.
Sequence:
MGDTGPRHSGGVCIEGSPWIWQLLQQCVGNAWEYWSVIVGLLSITCFLFAALPQLYVAHTNGRVDQALSLGFLLCWFGGDFTNFVGCYLTNQLPLQIITAILYVNMDIIMISQFSYYKLKNNRLKGNGSLKGICILWVVLSITLSIILPSQLLLKKHDKNTDVEVNQKTIGITEMSGFICGYVSSVFYLGSRFPQLHKNFHRKSTEGTSYLLFALAMLGNCTYGMSLLLKLPAVRHHKSQYIIHHLPWLIGSFGVLILDFFMTAQFIIYQKNKTNKTKDLFAIEVEPLLVDEKEI
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MEQLVNELIEADVGRVLVNEPLARYTTMKIGGPADILIVPKHVAGIEKTLQLVKQYKTKWTVIGRGSNLLVSDQGIEGVVIRLGEGLDHLEVEKHKVRVGSGYPLIKLSTLLSRQGLAGLEFASGIPGSVGGAVYMNAGAHKSDISSVLSKALILFEDGAIDWLTNKELEFSYRASVLQTKRPGIVLEAVFQLQAGKREEIVRSMQNNKDYRRETQPWNHPCAGSVFRNPIPHFAGDLVEKAGLRGYRIGGAQISEMHGNFIVNTGGASAQDVLSLIELIKHTIKDKFDVDMHTEVEIIGR
The following text describes a protein:
Function:
Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes.
Subcellular Localization:
Secreted.
Sequence:
MLNLEEEGTSRSVMPQLVFILICHALTLLQASAGEECQSYEMSKLKEEIRMLNNKLLIGEWKVMHLRTHRKFRLVPNLELQENKPSENNTEPSPTLPSTGGSLLVHDKDCSELYDRLKPVSGFYRIKPKPLLEPFLVYCDMDDGGAWTVIQKRINGKVDFDRKWEDYKNGFGNFQSSKDEFWLGNDHIHVLLSDGDSVMKIDLTDWKGGKSYAMYDNFKVSDEKDKYRLYYGMYSGQAGDALSGGANMVEQWSASHNGMQFSTRDQDHDRYLQGSCAAENKGGWWYNRCHAANLNGRFYRGGEYKAKYDNGIVWSTWKGLWYSLRHTVMKVRPSSHMDSVGSGGGPTE
The following text describes a protein:
Function:
Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1401-|-1402-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Cell surface.
Domain:
The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix; The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence:
MLLLGISILALAWRPAGSSEPEWEVVVPIRRDPDINGRHYYRRGTEDSGDQGLIFQITAFQQDFYLHLTPDAQFLAPAFATEYLGVPLQRLTGSSLDLRRCFYSGYVNAEPDSFAAVSLCGGLRGAFGYRGAEYVISPLPNTSAPEAQRHSQGAHLLQRRGAPVGPSGDPTSRCGVASGWNPAILRALDPYKPRRTGAGESHNRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLGDRDTGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPITLPEDLPGTSYSLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKFCLKGACVERHNPNKYRVDGSWAKWEPYGSCSRTCGGGVQLARRQCSNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCTPDSTSVCVQGKCIKAGCDGNLGSKKKFDKCGVCGGDNKSCKRVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSVLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSTRPKDPRGSPVLRNSVLSLSNQVEQPDNRPPARWVAGSWGPCSVSCGSGLQKRAVDCRDSPGQQGASACDVDHRPLEKRACGEPCPTWELGNWSPCSKSCGRGFKRRPLKCVGHGGRLLARDQCDLRRKPQELDFCVLRPC
The following text describes a protein:
Function:
Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MIRFEDVSVTYDGATEPTVRAVDFEVPEGELVLLAGPSGVGKSTVLGAVGGLVPHFTGGTLRGRVTVAGRDTRTHKPRELADVVGTVGQDPLSHFVTDTVEDELAYGMESLGLPPDVMRRRVEETLDLLGLSDLRSRPIATLSGGQQQRVAIGSVLTPHPDVLVLDEPTSALDPAAAEEVLAVLQRLVHDLGTTVLMAEHRLERVIQYADQVVLLPAPGEAPLIGAPAEVMAVSPVYPPVVGLGRLAGWSPLPLTIRNARRRAAPLRERLAGREIPDHTPPPSAPLPAPPAPRPVTSRWRRRGKRPENPSAPTPYAAEVRSLAVRRDRVQALRHVDLTVSPGETVALMGRNGAGKSTLLSALVGLVEPSAGSVRAGDAVPHRTAPRDLVRRVGLVPQEPRDLLYADTVAAECAAADRDADAAPGTCRALLSELLPGITDDIHPRDLSEGQRLTLALSVVLTARPPLLLLDEPTRGLDYAAKARLAGILRGLAAEGHAIVLATHDVELAAELAHRVVLLAEGEVIADGPAADVVVASPSYAPQVAKVLAPRKWLTVAQVREALT
The following text describes a protein:
Function:
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.
Subcellular Localization:
Cytoplasm.
Sequence:
MNTPAYAEIGITTNFSFLRGGSDPRAYVHQASILGISAIGIADHNTLAGVVRAYKELDNDKVLHKPKLLIGARIVFIDGTPDILVYPRDRAAYGRLCQLLTRGKRGDDVTRIEKGECRLTFSDLLAFSEGQLLVLTLPHRFEPAQALDVLAKLKATRAEGVWLAASLVHRGDDRRRLARLDDLATTAKVQLLATNEVLYHDPARRPLQDVLTCIREKTTIEAVGRKLEANAERFLKTPREMSRLFRDFPDAIAETMRFANKIDFSLDQLRYQYPDEPVPPGKTAQGHLEDLTWAGVDKYFAGKIDDKLRATLKKELALIAELKYAHYFLTVHDIVHYARSQNILCQGRGSAANSAVCYVLGITSVDPTKVDLLFERFISKERLEPPDIDVDFEHSRREEVMQYVYRRYGRHRAAIIATIIHYRPRSAIRDVGKALGLTEDVTAALADTVWGSWGSGLNDMQVKQAGLDPQNPMINLAVELATELIEFPRHLSQHVGGYVLTQDRLDTYVPIGNAAMDDRTFIEWDKDDVDALNMMKVDVLALGMLTCIRKCFDLIDQHKGERWVLASVPQDDPKVYDMLCDGESLGVFQVESRAQMNMLPRLKPRTFYDLVIEVAIVRPGPIQGDMVHPYLRRRNGQEKVNYPSPSPEHGPADELYKVLHKTKGVPLFQEQAMRIAIEAAKFTSEEANGLRRSMATFRNVGTIGKYEDKLIGNMVARGYDPNFARSCFDQIKGFGSYGFPESHAASFAQLVYISSWLKYHHPDAFCCGLLNSQPMGFYAPAQIVGDARKNGVEVRDIDVSYSFAQNTLEQGSGKYCAVRLGFRQIDGFHWLDEDEEHLKRSLLSFRGAPLGANPESIGPHMPGGMDSGLDAGASPRNDKKEDWANRIVAARNRRPFTSLEDFARDTGLPKRALILLADADAFRSLGLDRREALWQVRRLPDDVPLPLFEAATAREQPDEHAKPLPLMPRPEQVVADYQTIRLSLKGHPMEFLREMLSRERVVACKDVNHQNERRRVRCAGVVLVRQRPGSASGVVFMTLEDETGIANVVVWPKIMEQYRKEVMGARLILVEGYIQSSPEKVTHLIAQRMVDRSHDLIGLANDSLTRKHPVPSGDALIEPLNDDRRDHADAPAQKIRHPRNVRILPPSRDFH
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Sequence:
MADEDPVDQKKYLEEACKPKCVKPLLAYQECVKRIQGDESGHKHCTGQYFDYWSCVDKCVAPKLFSELK
The following text describes a protein:
Function:
Choline uniporter that specifically mediates choline uptake at the blood-brain-barrier. Responsible for the majority of choline uptake across the blood-brain-barrier from the circulation into the brain. Choline, a nutrient critical for brain development, is a precursor of phosphatidylcholine, as well as betaine. Also mediates transport of ethanolamine. Choline and ethanolamine transport is not coupled with proton transport and is exclusively driven by the choline gradient across the plasma membrane. Also acts as a heme b transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
HLNPNPSRQAKGMDLNENGVYSEAKEPDRTQQSNGVPTRLESRRWLILFLFTFYSLSNAYQWIQYGIINNIFMKFYGVDGFSVDWLSMVYMLVYIPFIFPVTWLLDVKGLRVTALVANALNCAGTWIKVASARSDMFWVTMLGQLFSSVAQVFILGLPARIAGVWFGADEVSTACSIGVFGNQMGIAIGFLLPPILVPNVNDMNELTHNIRVMFYISAGVATFIFILVAIVFEERPENPPSLSQAQARSICADKYSYTASICRLLVNKPFMLLVISYGLNVGCFYAVSTLLNRMIIEHYPGEEVNAGRIGLTIVTAGMGGSLICGIWLDKTKTYKLTTLVVYILSLVGMLVYAFTLNLGHLWVVFVTAGVLGFFMTGYLPLGFEFAVELTYPESEGTSSGLLNCSAQIFGIIFTIGQGKIMDRWGTFAGNIFLCIFLLIGTVMTGFIKSELRRQKANEQVESVSTFGADV
The following text describes a protein:
Function:
Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly.
Subcellular Localization:
Cytoplasm, perinuclear region. Cell projection, lamellipodium. Golgi apparatus, trans-Golgi network. Note=Colocalizes, with AKT2, in lamellipodia. Colocalizes, with HERP1, in trans-Golgi network.
Domain:
The RING finger domain is required for ubiquitin ligase activity and autoubiquitination.
Sequence:
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVEQLPSNILLVRLLDGIKQRPWKPGPVGGSGTNGTSALRAQSSAVVTCSPKDGPSSQGGPQPRAQAWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIVLRRQVDENWYHGEVGGVHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDQPPGPGVAAGEGALATTPSSTTTKQPDGKKNTKKRHSFTSLSMASKASQAAQQRHSMEISPPVLISSSNPAAAARIGELAGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPAEAPYPAALATLNPPLPPPPLQAATPTGTAVAAAAGMGPRPTAGPTDQTTHPRPQPRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTSASQGKVPMLTTGPASRGGVLANPPSTGGPAQKPPGNGVAGGPGVPTAVVSAAHVQTSPQAKVLLHASGQMTVNQARSAARTVSAHSQERPTAAVTPIQVQSTPGQSHHPLVSPQPPAPLGPPAHAAASGLGRVGGPLACATAPASIPAASLEPEPSSRPATLLPGTPTSPDSGSAARPDKDGKKEKKGLLKLLSGASTKRKPRGSPPASPTLDAELGAELSCGPPGPPCACPGPCDGDTMAPGPQRRASSLDSAPVAPPPRQPCSSLGPAASEVRPAVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI
The following text describes a protein:
Function:
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSKMCSSVEIGDSMIYIFLFLILLIIDQYSKFIVDSTLSVGETVPVIDGFFNLTYVQNRGVAFGLFQGKIDIVSILAVIAIGLILFYFCKNFKKISFLERIAYTMIFSGAIGNMIDRLFRAYVVDMLDFRGIWSFIFNFADVWINIGVVLIIVEHIFFNRKKRVK
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPPESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSGLRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNKDLPRVSVPNFGRTQSSDSAYV
The following text describes a protein:
Function:
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization). Involved in phospholipid biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRLQGKMDEYISERRYCYLYPALLLGGEVIKLILGEETIEHDRKTWYLLNGGNFVNQLFVHHGVLLWTLLMGLVLALQYHVRTTEFDPLPLDARQLGPVRRHPLKMLGSMAVQTVIKVLLVVTVLQALFWFMDHLFVWTGGRCTVSDTKDSVACRRLGGEWVGGFDISGHFCLVMNLSLVLWLELTELQRYMHSQEIQLRKFAWARTTVLGALGVWLALLAITAIYYHTFVEKLLGTIFGYSTSLVIYYVLPRINRGLHYL
The following text describes a protein:
Function:
Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.
Subcellular Localization:
Cell membrane. Synapse.
Sequence:
MKEHTSGANVEDLLRKSQMELQWIQRQLALMAARNKHQPHLYTKGKLKHEVSPHQAAGHSTAYSVNRFRMLEEKNRALKHHLATLCQEKQHYRKLKAKLQAALREKNHLNFEVIKHQLKASKYDQVQSDYDQLRQTFTVVSQERDTAQQQKSQLQVKVDNLEHVLKLMHEAVELKQQLQTEYEQTFVALHTKQKEINRLQKAWVQTDQEHEEALHLLKVKVRDLEQVCRSFSENLNQLPNELLDYYLQSAPVEIKSDLSWKNQIQSTQRETLPPTTAGFEAQSKKGQTQPPELRSIKSSPVATERPNSSSQFSPSEMEDEASPSPRSKPRYTGQVRLCTARYSYNPYDGPNEHPEAELPLVAGKYLYVYGEMDDDGFYEGELLDGQRGLVPSNFVEFVQDKEKPTGEGGNDLGPLEHTSLALVPVDGGTSQDGLLGSNNALVPYSNGTGGTLDPEDLAEDVVPYPRKINLIKQLARSVIVAWEPPVVPLGWGNITGYNVLVDGEIRASMPYGSRTKCLLEKLDLDACVYRVSVQSATDRGLSDELRCTLLVGANVVVAPYGLRVDDIQQDTAELSWLPSNSNYAHTVFLDGVEHAVVKSGRYRLRFHNLKPLTVYKVTVVAQPHQMPWQLPLEQRERKEAGVEFCTQAAGPPLPPHDVQVLCGQGQGVLQVRWKPPMLSSTGTSNGANVIGYAVCTKGQRIAEVLFPMADYVTVELSRIQCLEAREVIVRTLSLQGESQDSHVAVIPNNLLVPLPPIALPPPMHPRAGPPPQPHPQAHLQSPHLPHPTPQHPALPHPQPLPPNAPNPQTHPRLPHPCGPSQPQLHPHPQPQHPQPPHPGPRPHHLLPLLPHPHPHPVPQRPISARDLNAKEHTVHHGGALPPGQPGWDPMRSPSQPPVPMQGHTLEAPPQANLRSPSPQRILPQPRGTLIPDTVAKAIAREAAQRVAAEGGKGTRKHERYGDQGHSFHQHHSDEEEEDEEGFSRGRRRGPSVDEFLRGSELGRPSNTSGGGHHDREGGRQMHHGGPHPQRRPLMVPSIDGYRDRDRRSPTYYEESEPEEPFRIFVALFDYDPLSMSPNPDAADEELPFKEGQIIRVYGDKDTDGFYRGEIRGRMGLIPCNMVSEIRADDDETMEELIKQGFLPLCTPVDRIEQNRRGLRRDQASRRMVALYDYDPRESSPNVDVEAELTFCAGDIIAVFGDIDEDGFYYGELNGHRGLVPSNFLEEVPDDVEVYLTDTPSQHPQEGPTNRSNTNSATTVPEGKRAAPETNDTANNISIPVRAPSPIIRPLLPGTMRPLSPSRSSHIPRDPRDSQDLANKKKKGLLSKGKKLLKRLSPVK
The following text describes a protein:
Function:
Preferred specificity is towards 1-propanol.
Sequence:
MKAAVVTKDHHVDVTYKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEGIGVVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMAEECIVVADYAVKVPDGLDSAAASSITCAGVTTYKAVKLSKIRPGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDEQLKLATEMGADLAINSHTEDAAKIVQEKTGGAHAAVVTAVAKAAFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEGKVVPKVALRPLADINTIFTEMEEGKIRGRMVIDFRH
The following text describes a protein:
Function:
Metalloprotease.
Sequence:
MNNTALLAWGVAALMLLSAQAAPTGDSKEQKDIFEINQEAGLLGLACPGFKCDKDCDFGYDTDADGCFVCSCNPEDKEVLYQGDMLLDRRGKNRVLHGDSGNRGSVEGMHWPKVIPYVIHYSIAPGSSGRSAIDEAIADFHKYTCLRFTPRTNEEAYIKFYQGSGCSSPVGYSGYVNEISIGQGCGYKSIVIHEIMHSLGFYHEQSRPDRDDYVEIVWDNIESGMRYNFDKQSNIDSLGTPYDYRSVMHYGGTAFGIGRPARVTIKAKDTSKEHVIGQRSGFSQIDLEQLNLRYNCEGTYPALICEDGRKDLCPDLKSFCGSIKHMAFMMKYCLKTCGMCSDVASTVASTVASTAASTAASTAASICEDKYADCPRWKRECSINRYMKKYCAKTCGTCGGGVAPTAEPCQRGDGASYRGTVSVTDTGKTCQRWDRQTPHGHKYTPANYPTSGLEENYCRNPSGWSEVWCYTTDPGSRWERCDVPVCGGSGSSHADPAGDLAGAPAEGPCEDTYRMCPRLKRHCRDPKYQAMVKHCPKTCGTCGGGEAPDAEALCEDMHPTCPRRKRHCGKQRMQKLCPKTCGRCGRAL
The following text describes a protein:
Function:
Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol.
Subcellular Localization:
Nucleus membrane.
Sequence:
MEIILGESEAERAWPHGDSKDSYGPSTGVTNSDESQLLTPAKMNQRQAKEAYLTPTKDSLQPSLSPGSFHSQGFDRGKDDALQNKEDSSHTISKSKSESKLYNGSEKDISSSSKLTKKESLKVQKKNYREEKKRATKELLSTITDPAVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTPKNGQWVGTVLLNACELIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLIIRAASESDGRCWMDALELALKCSSLLKRTMIREGKEHDLNSSADSSHVTFYGLLRANNLHSAENFQLNDGEMERQHFKDQDMYSDKSDKENDHDHDESDNDGLGKSEESDSDTSERQDDSYIDPDPIELLKETTYLEQIHEELGEAGEASQTETVSEEHKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHANFLSEAALEENAYNRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKTYYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILDGEGRLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVSITCEKTGYSAVLEFKLKPFLGSNDSVNQISGKIKLGKEVLATLEGHWDSEVVINDKKTDVSETFWNPTCDIKQRRLTRYTVKFEEQGDFESEKLWQQVTRAINAKDQTEATQEKYLLEEAQRKATKDRKAKSEEWTCRLFEQDSISGEWQYKYADTRPWDPLNDMIQFEKDGVIQTKVRHRTPMVSVPKMKRKPSSQQKKGQSGCSSPELDNQDSSGSEAQLLKPTTRTRKKGIDLGELQSAIESIKQTQEEIKRNIVALRNRVVSNPPALDNSFLQQRDYFIIFLLILLQILINFLFK
The following text describes a protein:
Function:
May be required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (By similarity). Involved in vesicle fusion with nsfA and probably SNARE proteins.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein.
Sequence:
MSDKLKSNKKLEGETFMKEGDKLSKTNIFRWKADWDSAALAYEKAANAFRSAKIYDSAKYCFLRLSLCQTHMDVYYLAAKSMENASAMAKELKETQECANLLLESCKLYRTNGNSFQAADTMTKAAKLLEDIDLNQTIKLLTDACELFELDDKDHFSGDTFKQTISMLLKHKKYTEAVDLMILQNRVFVKLEQNHDLHKSCLSVITISLATDDIVASKKYYEQFLDYPSFIHSQEGTTAQELITAFDNHDVDGVKKIVSRHIFNFLDNQVAKIAKNLSISKDSLNPTINSTAPQQQYSNTTTTTTNNTNNNNPTSQQDDDEDVL