lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPKFQEMAAKTAFVSASMAAGSTSLIAKRYSVQEKLGRGSFGTVYLVLDTKAREGEKLKVLKEIPVGDLNPNETVQANLEAQLLSQLHHPTILKFYTSFLERDSFCIITEYCEDKDLECKIEEYKETKKSCPESQITEWFIQLLLGVHYMHERRILHRDLKTKNIFLKNNIVKIGDFGVSRLLMGSCDLATTFTGTPYYMSPEVLSHQGYDSKSDVWSLGCILYEMCCLEHAFTGHNFLSVVMKIVEGKTPVLPDRYSEELNSILQGMLNKDPSLRLSAADILKMKFIEEHLHNIKHKFSSMTLKEKTVNCKKEAAEIRNALQKKVHLETLREQSEVQKMTPRERMRLRKLQAADEKARKLKQLAEEKYQENCRRIQEFRSRNFQNVSVDVLHECQEQTVKQVNQTQPITAQDFKSLEKKVFPNVVNVIYYEIPEDPQTAELYYYEDRFESCSDEEEDEQEDSEEKPSDTLYRTCGQDTDVEAMVKCLEDVL
The following text describes a protein:
Function:
Peptidyl-prolyl cis/trans isomerase (PPIase) that acts as a key virulence factor by promoting host leukocyte transformation. Binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins. Promotes host leukocyte transformation by binding to phosphorylated host FBXW7, disrupting dimerization and promoting FBXW7 autoubiquitination and subsequent degradation. Degradation of host FBXW7, leads to stabilization of JUN, which promotes cell transformation.
Miscellaneous:
MISCELLANEOUS: PIN1 harbors a single amino acid variation in a strain resistant to buparvaquone (AC P0DMT5).
Subcellular Localization:
Secreted. Host cytoplasm. Host nucleus.
Sequence:
MIRNFLNFLWNNTSLRFLIINTIIFAMDKVRCAHLLLKHTGSRNPVNRNTGMAVTRTKEEAVSEMKGYLEMLRKSDNLDQEFRRLATAKSECSSARKGGDLGFFDRNTMQKPFTEASFKLEVNEISDLVETDSGVHLIYRIA
The following text describes a protein:
Function:
Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.
Miscellaneous:
MISCELLANEOUS: Present with 2840 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSSHHGHSLVPFINLLGIIYQIRDDYLNLKDFQMSSEKGFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKNDNENKYLPDLASHSDTATNLHDELLYIIDHLSEL
The following text describes a protein:
Function:
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MVQVYGEALQRRHYASRWSAAFCFRLASHVAILVLTFIFVHSSQGFWLKESTFTAQPAVRFTHDALLLLEGKGPGQEIFWSTFPTLNSALANKLAAVEVRATETDSDHDGNADVIDVSARVSGAGPVHSVKLLLQFRYQIQGRIRMQMQSLAYIHHASPLPGSELHVDGELRLRQRRPLSFDNNRVLYDVPALAPGGPSGQSLDSRSVQMQSILRDYLDRNETTEFVSSYAVWQAGYGTDFTIFERIRIPPFESVAYIPGLMEVLKYAWIQFLAVWILLLYLLSWVEYVTFRYRVLETRVVSDLQTQKQHRF
The following text describes a protein:
Function:
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Subcellular Localization:
Secreted.
Sequence:
MIYYGHTAGSLNLVQLQDDIDKLKADFNSSHSDVADGGPIIVEKLKNWTERNEKRIILSQIVSMYLEMLENTDKSKPHIKHISEELYTLKNNLPDGVKKVKDIMDLAKLPMNDLRIQRKAANELFSILQKLVDPPSFKRKRSQSQRRCNC
The following text describes a protein:
Function:
Part of the PduCDE complex that catalyzes the dehydration of 1,2-propanediol (1,2-PD) to propionaldehyde. Required for S.typhimurium growth on 1,2-PD as the sole carbon and energy source. Localized in the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation; The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
Miscellaneous:
MISCELLANEOUS: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate. BMCs can constitute up to 10% of total cell protein.
Subcellular Localization:
Bacterial microcompartment. Note=Probably located inside the BMC shell.
Sequence:
MNTDAIESMVRDVLSRMNSLQGDAPAAAPAAGGTSRSAKVSDYPLANKHPEWVKTATNKTLDDFTLENVLSNKVTAQDMRITPETLRLQASIAKDAGRDRLAMNFERAAELTAVPDDRILEIYNALRPYRSTKEELLAIADDLENRYQAKICAAFVREAAGLYVERKKLKGDD
The following text describes a protein:
Function:
Ethanolamine-phosphate cytidylyltransferase that catalyzes the second step in the synthesis of phosphatidylethanolamine (PE) from ethanolamine via the CDP-ethanolamine pathway.
Sequence:
MSTTTNKKPIRVYVDGCFDLMHFGHANALRQARELGDILVVGVHTDEEIAKNKGPPVMNEQERYKAVRACKWADEVAEGAPYTLTEEYLDSLNCDFCVHGEDISVGADGKDVYEGIKKSGKFRFIKRTEGVSTTELVGRMLLCTKDHLQNVSGEQTSPLGGVNPNVLHKQSPYTSLSHFLPTTRKIVQFSEGRSPKPNDKIIYMDGGFDLFHVGHTEALKQARALGDYLIVGVHDDRVVHEQKGSNFPIMNLHERVLSVLSCRYVDEVVIGAPFSVTKDMIDSLHINVVVHGDDQVVLGPEGGVDPYKLPRELGIYKEVKHTEGLTATEIVKRIIDNRLQYEARNRKKEAKEINFIEQSN
The following text describes a protein:
Function:
Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
Sequence:
MQVCFGQVITGAPGSGKTTFIKGMYTFLKLMGREPTIINLDPANEPNDYPISVSLPNLLSLDDAMKDTQLGPNGGMLYCLEYLNENIDWLIDKIIEIHPSYLLIDCPGQTELFATHPTLPTILHRLQQINCRLTAVHLIDSIHIGNPSIYLAAVLQGLACNMNLELPFVPFLSKADLLGGYGFNVKLEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKIEDICEGIMAFISMTLLSPIAVSQLSDVISQVILSPAVSEEATPAIIDVYDALQVPVCLQ
The following text describes a protein:
Function:
May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.
Sequence:
MAAPEAEVLSSAAVPDLEWYEKSEETHASQIELLETSSTQEPLNASEAFCPRDCMVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKHFYRKPSPQAEEMLKKKPRATTEVSSRKCQQALAELESVLSHLEDFFARTLVPRVLILLGGNALSPKEFYELDLSLLAPYSVDQSLSTAACLRRLFRAIFMADAFSELQAPPLMGTVVMAQGHRNCGEDWFRPKLNYRVPSRGHKLTVTLSCGRPSIRTTAWEDYIWFQAPVTFKGFRE
The following text describes a protein:
Function:
Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally.
Sequence:
MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAAAAQGPAAAAGSGSGGGGSAAGGTEGGSAEAEGAKIDASKNEEDEGHSNSSPRHTEAAAAQREEWKMFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIMEKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGGGPSQNWNQGYSNYWNQGYGNYGYNSQGYGGYGGYDYTGYNNYYGYGDYSNQQSGYGKVSRRGGHQNSYKPY
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVPFQLQPHQHHHKPHLIPQENHLVHRYHDHHNHNHNRRCGRRRSLDPTRSVAWFYYFREEAIVISGTQLDDRLVLVGLGLVTVVALALTHVGLNVLVALIIGFFVLGIHGALRGTEDLFLDENEAAEGGLLSVVSEEQIRPSYR
The following text describes a protein:
Function:
Small subunit of the arginine-specific carbamoyl phosphate synthase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, the first step of the arginine biosynthetic pathway. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MFSHLLKPAARSAGLLGHVNRRYLATVHTNTAREIPKPSRKPTPISLENATFTIKNGPIFSGKSFGAKANISGEAVFTTSLVGYPESMTDPSYRGQILVFTQPLIGNYGVPSSARDEHGLLRYFESPNIQASGIVVQDYALKHSHWTAVESLAQWCAREGVPAISGVDTREVVTYLREQGSSLARITVGEEYDADEDEAYIDPEAINLVRRVSTKAPFHVSSSLGDMHVALIDCGVKENILRSLVSRGASVTCFPFDYPIHKVAHHFDGVFISNGPGDPTHCTSTVYNLRKLFETSQLPVMGICMGHQLIALAAGAKTIKLKYGNRAHNIPALDLTTGKCHITSQNHGYAVDPTTLTSEWKEYFTNLNDQSNEGLIHASRPIFSAQFHPEAKGGPMDSSYLFDKYIQNVQRYKDHQSSFSEKSNKPSPLLVDLLSKERVGVHPAQPDFEMHVPGRVEQVDVGGPVAPPYQPITAAA
The following text describes a protein:
Function:
Functions as a protein phosphatase inhibitor. It inhibits activity of the catalytic subunit of PP1 and weakly inhibits the activity of myosin-associated phosphates.
Sequence:
MSASTSSHRPIKGILKNKSSSGSSVATSGQQSGGTIQDVKRKKSQKWDESSILAAHRATYRDYDLMKANEPGTSYMSVQDNGEDSVRDVEGEDSVRGVEGKEATDASDHSCEVDEQESSEAYMRKILLHKQEKKRQFEMRRRLHYNEELNIKLARQLMWKELQSEDNENEETPQGTNEEKTAAEESEEAPLTGGLQTQSCDP
The following text describes a protein:
Function:
Plays redundant role with PV42a in regulating male gametogenesis and pollen tube guidance.
Sequence:
MQSYSRLMQFKVKDLMIDKRRLVEVPDNATLGDALNTMVANRVRAVPVAAKPGQWLGAGGSMIVELDKQSGSARKQYIGMVTMLDVVAHIAGDDGESGLDKKMAAPVSSIIGHCPEGLSLWSLNPNTSIMDCMEMLSKGIHRVLVPLDSNTENITGPELVESASAYAMLSQMDLISFFFDQSSQLHGILSHTVTDLSAIHNTVLALTSQARVKDAIQCMSIAMLNAVPIVEASGEGEDHKQLVDGKNRRVVGTFSASDLKGCHLATLRSWLPLNALEFVEKIPRTLLFTAATSTPGRELVTCHVTSTLAQVIHMVTTKRVHRVWVVDQNGGLQGLVSLTDIIAVVRSALLSGAPDLF
The following text describes a protein:
Function:
Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAEEADFATLMDVERNTITEVHSQVVEIIAGCGDSSTITELEIAGAVVTDMLEEAHIVASETVGNTGPSDSDAQESENKHALGNDMNTIKPDFDADVIVPEAKVDVGKPFTEADGSAIDTGGSHEVLTPSDPDAQTETPAEDPVETEAVNDASNTTDEPVPDTKGLGHDATSVFSNETNTAITTLDVSASEADRSVRETLSVDQEEKKTDEESSLFESQTQQSSEDNSEEALEETSGPEPVTSATTEKLQVEVFVPERALAVPLTPNKEECQENGAALVEPELSPQDTEAAFVAPEVENSEEPDSSENEELLNEIQDENGVESGDETQQENGSQSPVASAQASGEIPSSGKKPDINRHSYSKYNTVSYRKIRKGNTKQRIDEFESMMHI
The following text describes a protein:
Function:
May play a role in the regulation of cytokinesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEKMESTEEWEALLSSSSNGDELTMKLIRNGLAKGFKSQKAAGDAGLYSRFLPYHFTESVSNDSFSSLPWQIFANSVAGNSPLQNEAWAFLMDNEDFFLPVPMNPAQCTALEIALWSLIRVDDQRLFELCHSKSGIRLLSIIFDFDSHPDWLREDVMFNIAERILKSNFPNVLVNVASKIGPKSIYFLIDCMSHKIKLKETATGFYVILDVLSCVGRQFASVLEECFTKEISSAGLDHINHFSEIVMLGVDLLYRDYVSYDTTISLKNDDSSSLGDMEFETSQPSSSISEIIHLLAVLDKRIPKKTLVEKTYASSMELQELYNAVVGVKRECVRFIAFICSKFSTAPDLVRHFNGVALIISQANYDDWNPYIREISVLCTRLLLQNNIENQKIIGGLTPITTTHSDALEEAGFTSYINDKGKVVLQPKTAKNSH
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MKGSDIPHVEANYVDLGRAVGTVCDNAHRELANVLETLPSTPADVAKKQALLEVLVRARQEFVRTYVLTKWAKVSEDVTKCIDVVAWLHGQRNCFDNLNHMLVGLGRDLGAAKSRNPDLQTAVQVLTRGAPTTFGDHDMAPKKKLKPQTILRTLRDLNVLLSVQLAQSTDIPPQFKRYKIANGRATFTVANAFEVDVGIADDTLDGPFFFIDFRLLFGDRKELPPQTRGMLERAGNSALAQRGLSALYSLLMKFALNYKLALIYKQIMEMSKGLWSGTLRHRFYQERSLIALEYWVSQHATHRPKSTLEIGIFSESDLRIAVRWSRQGEEVPYSEHQIQFGGESTDVASLLEYVTTLHLKHIISCVYTKLRALLGDSSDMVSLCSDGHKLRFRLTSLRSTVFTVDRLTGKTVLENATSLILSAERSLNELVSRPDQAASVLFKLRLLSLENDIRTRACATGWTAQNVTLSTDEMKTHFGFTTRYVLFLRQPQWPSNWFVVVTVPEDGSLPLWWIAKLRVRKDTAWTAECMDRIHVNQDLDSLYDYELLTQMVTFASHRIVLHPILDELRAAKTPFRLLRSAQHTPVVAIDNSALVTSWSHSSLLILPEMSAGSMDMKLHVQGRAKTVMNLPSNDSIDFDASTGIYKLTLEGANTPGFSLVNKLKERLQQIEQIVSYIELIKDLGLELVTASMQQIKFKLGDAQVSVDIPSELNPNITLHLSPTDPHNIIHSYLQETLNSSGLRPVVWLLQTTRNLYTTLQKLQKTRGGDPEQLEKIISNLSISDLETRQKQLQPRLSIVPRSAAFVRLVYPGKMNIDVTLVRHSATLDGVKFFIKESPLELPPPPQPGQPPVAVPRKLQVWNGSVTPDVDVGKAVYLNDGIACEGDNVGKVLEWVDKQIGK
The following text describes a protein:
Function:
Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM). Catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 6 of a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1) to generate phosphatidyl-myo-inositol bearing alpha-1,2- and alpha-1,6-linked mannose residues (Ac1PIM2). PimB also catalyzes the addition of a mannosyl residue from GDP-Man to the position 6 of phosphatidyl-myo-inositol bearing an acylated alpha-1,2-linked mannose residue (Ac1PIM1) to generate monoacylated phosphatidyl-myo-inositol bearing alpha-1,2- and alpha-1,6-linked mannose residues (Ac1PIM2). The addition of the second mannosyl residue by PimB preferentially occurs before the acylation of the mannosyl residue transferred by PimA. Also able to transfer a mannosyl residue from GDP-Man to the position 6 of a phosphatidyl-myo-inositol (PI), but this reaction is very slow.
Sequence:
MLLVTNDFPPRRGGIQSYLEAFVGELVRTHELTVYAPKWKGAEEYDEKAARSGYRVVRHPTTLMLPEPTVASRMKRLIGEHDIETVWFGAAAPLALLGPLARRAGARRIVASTHGHEVGWSMLPVARTALRRIGNDADVVTFVSRYTRSRFASAFGPSAALEHLPPGVDTDRFAPDPDARARMRERYGLGDRPVVVCLSRLVPRKGQDMLIRALPELRRRVPDTALAIVGGGPYLETLQRMASDLGVAEHVVFTRGIPAEELPAHHAMADVFAMPCRTRGAGLDVEGLGIVYLEASACGVPVVAGRSGGAPETVLDGKTGTVVDGTDVDAITTAVGDLLADPRRAAAMGVAGRHWALDNWQWRTRGARLAELLSGRREARQA
The following text describes a protein:
Function:
Intrinsically disordered protein acting as a chaperone. Prevents heat-induced aggregation and/or inactivation of various substrates. Binds to acidic phospholipid vesicles without affecting membrane fluidity.
Sequence:
MAEEIKNVPEQEVPKVATEESSAEVTDRGLFDFLGKKKDETKPEETPIASEFEQKVHISEPEPEVKHESLLEKLHRSDSSSSSSSEEEGSDGEKRKKKKEKKKPTTEVEVKEEEKKGFMEKLKEKLPGHKKPEDGSAVAAAPVVVPPPVEEAHPVEKKGILEKIKEKLPGYHPKTTVEEEKKDKE
The following text describes a protein:
Function:
May function as a co-chaperone.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
PCASAAMTKSLLLTYVLWLTGGWFGAHHFYLGRDRHAFVWWMTLGGYFGIGWLRDLWRIPEYVKLANRDPAATEQLKEKIQRNAKPVSSTARSVGQMVVSDALGYMVLYALPLDVIPESLLPLAAIPVPLAVAVGKPATFWWVSFGGCLWRVVRNLFSAFRVRPTLVIRFPLPVFWSSLASSYMFNHHSKRWRLVPRPQRSLRWRLLVLAACCLLYGSLWASWLYFNCSVTDSDGTQVKCRHSLRHFFGSPLWRDFKNVAHELYTHLRHHGWRELWRLLVDALDPQGEASALKVLGLPASATQEEITNAYRKLSRRWHPDRFHEPLQKQEAQETFIEIQKAYETLSSLKSRRLKKNIVERENPNAPRVEF
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Acts as an organizer for autophagosome biogenesis in a GTP-dependent manner. Involved in retinal homeostasis by autophagy regulation.
Subcellular Localization:
Cytoplasmic vesicle. Cell projection, cilium. Note=Secretory granules. Located mainly in the connecting cilia between the outer segment and inner segment and also observed in the outer plexiform layer, inner plexiform layer, and ganglion cell layer of the retinas.
Domain:
Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.
Sequence:
MTGTPGAVATRDGEAPERSPPCSPSYDLTGKVMLLGDTGVGKTCFLIQFKDGAFLSGTFIATVGIDFRNKVVTVDGVRVKLQIWDTAGQERFRSVTHAYYRDAQALLLLYDITNKSSFDNIRAWLTEIHEYAQRDVVIMLLGNKADMSSERVIRSEDGETLAREYGVPFLETSAKTGMNVELAFLAIAKELKYRAGHQADEPSFQIRDYVESQKKRSSCCSFM
The following text describes a protein:
Function:
Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.
Sequence:
MFNKVLHKQVPQELQKLQTITEAIQNFDVRFPVPGSQNQTGSILAIDCEMVECKNEIGASVQMLARITVVNYNGYVVLDQYYKPRFKVRNYITRISGITPQIIKDKPVYNDFEKQKLQLLFKDKTIIGHTLKSDFDAMEFDLFNESRLFEIRGGIKQYSQLNKGLKKMCLKYLGQNIQQGQHSSEIDARATLFIFRKFRNEINLHYKQLDLEQDKQRIQKKNSQKNSKNQRKRSQKEVLNKESENQRKQCNEPLSRNDQQKQVQIQKKQISKKKSS
The following text describes a protein:
Function:
ADM function is mediated by the CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes with ADM showing the highest potency for the CALCRL-RAMP2 complex.
Subcellular Localization:
Secreted.
Sequence:
MDLCQAILLLHFICLTFLGLVAGRMEFIPGDRKKWSSLGMNRLRRDLKVAVQSAPATDVASESSFVKNEDVKGPLNSQHSSNDAHIRVKRYRHTFHHLQSVRVGCRFGTCTVQNLAHQIFQYTDKDKDSTAPVNKISSQGYGRRRRSLPDKKLQLTVMDGHIKPHWVSTSTSRNQPGGHQPKFLDVISAGKPSQGRETWKKGKMLQILLKT
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
Subcellular Localization:
Mitochondrion.
Sequence:
MASNCVTVCPKRLPKMNRNVFMQLEQMVRLHNTCRKLHALCHTNARIKWRLVQCPPLAVCVAHLCPPSWQTDTFISVALSQYRCLSSKEGKSFKKHKLSPIKPKQEKQEVEIWNNMTVGDLARAMNKDTEHVYEALLHTDLDLEALEEKSVLSEKWIKEAIKKSGMKFKYAKIKEEKVRENKDAVKRVPADPAVLIPRPPVITIMGHVDHGKTTLLDQLRKTQVAAMEAGGITQHIGAFNVQLPSGERITFLDTPGHAAFSAIRERGANVTDIVILVVAAEDGVMKQTVESIQHAKNAKVPIILAINKCDKPEASPEKVKKELLSHDIVCEEYGGEIQAIHISALKGHNLQALTEATVTLAEMLELKADPTGLVEGTVVECRTDKGKGPVTTAIVQRGTLKKGAVLVAGKTWAKVRLMFDENNKALSQAGPSTPVEIVGWKDLPSAGDEILEVETEQRAREVVDWRKYVEEQEKIIGDMEVIEAKQKEHRDAYKKNLETFSNLNWRQRKSAMYKANKQLMATRPGEKSESETPMFPLIIKGDVDGSVEAILSIIDTYDAEDQCELDLVHFGVGDISENDIALAETFKGYVYGFNVNSNKAVQQLAAKKEVTVKLHKVIYHLVEDLREELSKQLPPVIEENIKGEASVLATFDVTVGKKKVQVAGCRVQKGILDKKVKCKVIRNRKMIWEGYLTSLKHLKDDVQTVKTGVECGLSLDKDIDVKIGDEVLCVEEKEVQQKISWDPGF
The following text describes a protein:
Function:
SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.
Sequence:
MRLIHTSDWHLGQTLHGQDRDHEHARFLDWLLRQLEEQRADVLLIAGDIFDTINPPLKAQERLYDFIVSAHRRLPRLEIVMIAGNHDSGARIELPAPLMKRLNAHAIGRIGWIDESLDSDRLLLPLHDADGQVAAWCLALPFLRPAEVTGGGLGDDYLAGIRQVHERLVAAAHARRTPGQALVAVSHAHMAGGSVSEDSERNLIIGNVEALPASLFPEQIAYVALGHLHKPQKVAGQERIRYSGSPLPLSFAEVNYRHQVLLVTLEGERLKDVQSLPVPRAVELLRIGPAPLGEVLDRIGELAEADLLNEQRPWLEVRVMLDQPQPDLRQQVESALLGKACRLVRIASEYQRRDEEQAPLLGLDQLNPQELFSRAWESAYGSGPDAQALDDFASLLQSVELATEEPPGK
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
Sequence:
MMETQLYIGIMSGTSMDGADAVLIRMDGGKWLGAEGHAFTPYPGRLRRQLLDLQDTGADELHRSRILSQELSRLYAQTAAELLCSQNLAPSDITALGCHGQTVRHAPEHGYSIQLADLPLLAERTRIFTVGDFRSRDLAAGGQGAPLVPAFHEALFRDNRETRAVLNIGGIANISVLPPDAPAFGFDTGPGNMLMDAWTQAHWQLPYDKNGAKAAQGNILPQLLDRLLAHPYFAQPHPKSTGRELFALNWLETYLDGGENRYDVLRTLSRFTAQTVCDAVSHAAADARQMYICGGGIRNPVLMADLAECFGTRVSLHSTADLNLDPQWVEAAAFAWLAACWINRIPGSPHKATGASKPCILGAGYYY
The following text describes a protein:
Function:
Essential for recycling GMP and indirectly, cGMP.
Subcellular Localization:
Cytoplasm.
Sequence:
MKREGVLYILSAPSGAGKTTLCREIIDIFPQLRHSVSYTTRTPRPGEIHGKDYFFVSMDEFHRMIDADEFAEWAEVHGNCYGTSIRTLEENRAAGVDLILDIDIQGARQLQERFAGGVYIFILPPSFEELRRRLNGRSSDSDEVISRRINAAAGEIRESRWYDYIIVNDQFSRAVEELKSVIIAEQCRTARVLDAVSEIFSMD
The following text describes a protein:
Function:
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MLSKKRGLSLEEKREQILQIFYESQDFFLLRELEKLGPKKGVISQSVKDVVQSLVDDDLVSKDKIGSSVYFWSLPSCAGNLLRNVYRKLEADIESSKKRFSELTEYRNSLKKGREETDEREEALSELKAIEIKYNQLKEELGRYAENDPAALEAMKNAISVAHAAANRWTDNIFTLRQWCSNNFPEAKEQLEHMYKEVGMGDDFDYLEPAVLVSASAVGE
The following text describes a protein:
Function:
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
Sequence:
MARKALIEKWNKTPKHSTRAYTRCRICGRPHAVLKKYGICRICFRELAYKGEIPGCKKASW
The following text describes a protein:
Function:
Acts as a decapping enzyme capable of hydrolyzing monomethylated capped RNAs (in vitro). Hydrolyzes monomethylated capped RNA after alpha and beta phosphates to form N(7)-methyl-GDP. Shows low activity towards unmethylated capped RNA.
Sequence:
MSTPRIPRVPIYLKKSNQHILAGFGECVVNFFGFADKGSGYVRLTQEKDGFLIHEVNSLDDPHAVLLKHASECPVHKMTDKASLTQECKDKGVGMGVAILLTSMDQCVLVTRRAPHMRTFPGVWVPPGGHVEPGETLLTAGLRELKEETGLEIRDTSHHLLGLWESVYPHKLEFGDPQRQHIVIYLVLNSSLSSKELTEQIRLDPDETDAAMWLPYPFVEKLSTGNSVEDLPKYLSVLQNVNGKNEKYSVDTGPIVEAIAPPIDSTQLDIERLTWGTRFALQQWMKWN
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Endomembrane system; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MILSVAIINQNGKPLVARQFSKVSKAQILNQLGVFPKLLTKTSQSYVESQNIRYVYQNLDKLYFILITTKDSNILEDLELLSMLIDLTRTIIPTIDETTVLSHNLDLIFAYDEVIFDGYRQTVSVNDVSEFLLMDSKEELQYLEELQKKEDEAKKFAAETQKILDKQKKSKTYSSASSVSYTPSEAASQSVSFTQFTSYEPEIDVEDEPTKSSSIPNVPRKQASNVKGMTLGKSRSAREKAKQVILEEGLHPTSSKADAPVSAPTPLITEGLLFEFEESFSGSLNYESDGKFTCYGYLYGLGRNAGKYTIQVNWDNSFTAYKNPVKNTKQLSFDNTKPSSQRTEIVKYINTNCRKENLPIELLVWPTDPQSSKSKATLQLQVSKNSDSTQNVGQVKIRIKVLDPSSATITLDQDSGEYEVEGNEVVWTTPDISEEDSFTLEIAAMQTVADFFDIEIFFNAECLYSNIDITNVFKEGEEDNPVEYKVNKKFTSGETTHFMIKY