lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium. Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1). Accelerates proteasomal breakdown of ubiquitinated proteins as it disassembles free ubiquitin chains that would compete with ubiquitinated proteins to bind to the proteasome.
Miscellaneous:
MISCELLANEOUS: Present with 3040 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAEAVLENVNVPAVVSKDECIYCFESPYNEPLALNASPKHSLNICLNCFQATCNRHVPLHIRVTEYACDTIHSNYLTIAKVEKPKQENVEENNNNKKIKLQVIETSEDDTHNTIWSLQRFNGENVPRTVLSKSTDSDISSTALEKIEKILKAKSQDFEDKKNSWVLEISTCPHTENFQIPSKPENTVNLNQCSSCDLTQNLWLCLHCGNIGCGREQIGIDGHSHALDHYRSNNNHPLAIKLGSLSSSTYDLYCYACDDETRFPDNVNLGSALQIYGINIQEKIADEKTLVQLQVEQNENWQFRMVDSSGKEFEKLSASKNYGCGLINLGNSCYLNSVIQSLVNGGVPNWSLDFLGSKFPLDVVYPDNNLKCQWIKLLNAMKCEPELYPNGIKPTTFKKCIGQNHQEFSSNRQQDAMEFLTFLLDLLDKKFFSSSSSGIPNPNDLVRFMMEDRLQCNICGKVKYSYEPTEAIQIPLEENDEPQDMLERIKAYFEGQTIEFKCANCKEKVTANKKPGFKSLPQTLILNPIRIRLQNWIPVKTSNELSLPGLIDRDDMLDVSSYLSQGFDPQTENLLPDEDENRSSFTPNQCSISQLIEMGFTQNASVRALFNTGNQDAESAMNWLFQHMDDPDLNDPFVPPPNVPKKDKREVDEVSLTSMLSMGLNPNLCRKALILNNGDVNRSVEWVFNNMDDDGTFPEPEVPNEEQQQKKDLGYSTAKPYALTAVICHKGNSVHSGHYVVFIRKLVADKWKWVLYNDEKLVAADSIEDMKKNGYIYFYTRC
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Subcellular Localization:
Cytoplasm.
Sequence:
MATIKEIKELLVTVKELESPIFLELEKDNRSGVQKEISKRKRAIQAELDENLRLESMLSYEKELYKQGLTLIVGIDEVGRGPLAGPVVAAAVILPKNCKIKGLNDSKKIPKKKHLEIFQAVQDQALSIGIGIIDNQVIDQVNIYEATKLAMQEAISQLSPQPEHLLIDAMKLDLPISQTSIIKGDANSLSIAAASIVAKVTRDELMKEYDQQFPGYDFATNAGYGTAKHLEGLTKLGVTPIHRTSFEPVKSLVLGKKES
The following text describes a protein:
Function:
Porin with a specificity for basic amino acids. Involved in facilitated diffusion of carbapenem beta-lactam antibiotics, such as imipenem and meropenem. Also possesses serine protease activity.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKVMKWSAIALAVSAGSTQFAVADAFVSDQAEAKGFIEDSSLDLLLRNYYFNRDGKSGSGDRVDWTQGFLTTYESGFTQGTVGFGVDAFGYLGLKLDGTSDKTGTGNLPVMNDGKPRDDYSRAGGAVKVRISKTMLKWGEMQPTAPVFAAGGSRLFPQTATGFQLQSSEFEGLDLEAGHFTEGKEPTTVKSRGELYATYAGETAKSADFIGGRYAITDNLSASLYGAELEDIYRQYYLNSNYTIPLASDQSLGFDFNIYRTNDEGKAKAGDISNTTWSLAAAYTLDAHTFTLAYQKVHGDQPFDYIGFGRNGSGAGGDSIFLANSVQYSDFNGPGEKSWQARYDLNLASYGVPGLTFMVRYINGKDIDGTKMSDNNVGYKNYGYGEDGKHHETNLEAKYVVQSGPAKDLSFRIRQAWHRANADQGEGDQNEFRLIVDYPLSIL
The following text describes a protein:
Function:
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties.
Subcellular Localization:
Cell membrane. Cytoplasm. Nucleus.
Sequence:
MAYIPDGGPPTAGGIPLGSQCCVCKVELSVSGQNLLDRDVTSKSDPFCVLFIEDNGRWMEFDRTETAINNLNPAFSKKFVLDYHFEEVQKLKFALFDQDKSSAQLDEHDFLGQFSCSLGTIVSSKKITRPLLLMNDKPAGKGLITIAAQELSDNRVITLSLAGRKLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDLEKPIQVMCYDYDNNGGHDFIGEFQTSVLQMSEARDGVPLEMECINPKKQRKKKSYKNSGIIILRSCKIHRNYSFLDYILGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDRMLPLSECGPSVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATEQQTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDNRRLRSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNLPPTNSEPA
The following text describes a protein:
Function:
May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MRVAKWLTGLLCPISLLLTGSWEVRFHPRQEALVKTLASYEVVTPTRVNEFGDVFPQNRHFSRKKRSSGVPEPPPFRTHYRISAYGQLFQLNLSADAAFLAAGYTEVHLGTPVPGPGGRSTESPDLRHCFYRGQVNAREDHTAVFSLCGGLMGTFKANDGEYFLEPVLRADGSAHDDDHNKPHLIYRQELKRNSFARSHKPCEVSENQMEKTALPSQSSRNTTGDVDIEEEAVFRLEGERSQLHSRNKRFLSYPRYVEVMVTADAKMVHHHGQNLQHYVLTLMSIVAAIYKDSSIGNLINIVIVKLVVIHSEQEGPVISFNAATTLRNFCLWQQSQNVPDDAHPSHHDTAVLITREDICGAKEKCDTLGLAELGTLCDPSRSCSISEENGLSAAFTIAHELGHVFNVPHDDSFKCKEAGIKHQYHVMAPTLNYHTSPWTWSACSQKHITEFLDTGHGECLLDKPNGRTYDLSPQLPGSVYDGNRQCELMFGPGSQVCPYLKHCRRLWCTSAEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCVTRDMETRPVDGEWGPWGPYSSCSRTCGGGIKSTARLCDRPEPRNGGRYCVGRRMKFRSCNTDSCPKGKRDFREKQCSDFDGKHFDINGLPPNVRWLPKYSGIAVKDRCKLYCRVAGTTSFYQLKDRVADGTPCGTETNDICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSCQTLAGVFNSAHYGYNVVVKIPAGATNIEILQHSYSGRPEDDNYLALSDTQGNFLLNGNFVVSMAKKEINIQGAVFEYSGSNNSIERINSTDRLEAELVLQVLCVGNLYNPDVRYSFNIPIEERSNLFSWDPYGPWQDCTKMCQGLHRRKIACVRKSDHAVVSDHNCGHLPMPLFVTEKCNMDCELRWHIIGKSDCSSQCGQGYRTLDVHCMKYSVHKGQAVPVGDQYCGDQLKPPSREPCHGSCVLTRWHYSEWSQCSRSCGGGDKTRESYCVNGFGHRLAESECRELPRVVLENCNEFPCPSWATSEWSECPVTCGKGMKQRQVWCQLSEDPMRDGFCNASTKPESLRPCELRACASWHVGPWGSCTATCGHGYQMRAVKCISEIFGTMLDDRECPQASRPSDRQDCILAPCLAIPEVGATSLPAIPLGRAAQWRHGSWTPCSVSCGRGSQARYVSCRDAHDEVADESNCAHLPRPAAVSLCFSPCGEWQAGDWSPCSASCGHGKTTRRVLCVNYHQLVDESYCDPEGRPVTEQECSLAACPPLYSRAPSSSEQPSHVPSRNVPLTHKPGENQDQGAQLSIRGNQWRTGPWGACSRSCAGGLQHRAVVCQDEDGRSATSCDGSSKPPESRHCGSGPCPHWNYGDWGECTQTCGGGVKSRFVICQFPNGQMTQEHSCELPKPPSMMQCHLHACPEDVSWYRGPWKSCSASCGKGVKYREVLCIDQFQRKLEEKYCSHLHKPRTHKACRSGRCPSWKANKWKECSVTCGSGVQQREVYCRLRGTGRVSEDMCDPSTRPQGQRQCWRQDCMRYQWTTGDWLDCSTSCKKKETYRLVKCVNEQNVQANESLCDPLTKPLSIKKCRNPHCKYSVVTGDSSQCAGNCGFTSPQKITYCTKIQSSKKHTFHQLRPVVYGECPVIPSPQAYKCDLRSCLHVATWKVGKWSKCSVTCGIGIMERRVACRTENGWPSDLCLKRLKPDAQKKCYANDCKLLTTCKELQVTNNVTKDGDYDLNVRGRILKIHCSGMQLENPREYLPLVKSEDNFSEIYGLRLQNPYECPFNGSRRPDCACENDYLPAGYTVFSKVRVDLESMQIKTADLLFSQTLSGKAVPFATAGDCYSAARCPQGQFSINLAGTGMKISNTAKWLAQGRYASVIIHRSQDGTKVYGRCGGFCGKCIPHMATGLSIQVL
The following text describes a protein:
Function:
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).
Miscellaneous:
MISCELLANEOUS: It has been proposed that the urinary and serum levels may provide a sensitive indicator of renal damage in diabetes mellitus and hypertension. Elevated levels in the coronary circulation may also be associated with angina. Changes in charge and molecular weight microheterogeneity, due to modification of the N-linked oligosaccharides, may be associated with neurodegenerative disease and multiple sclerosis. Detected in meningioma but not in other brain tumors and may be considered a specific cell marker for meningioma. Expression levels in amniotic fluid are altered in abnormal pregnancies. Levels are lower in pregnancies with trisomic fetuses and fetuses with renal abnormalities.
Subcellular Localization:
Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear region. Secreted. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.
Domain:
Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Sequence:
MATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKFLGRWFSAGLASNSSWLREKKAALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPAGSLGSYSYRSPHWGSTYSVSVVETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFTAFCKAQGFTEDTIVFLPQTDKCMTEQ
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MMFLPTDYCCRLSDQEYMELVFENGQILAKGQRSNVSLHNQRTKSIMDLYEAEYNEDFMKSIIHGGGGAITNLGDTQVVPQSHVAAAHETNMLESNKHVDDSETLKASSSKRMMVDYHNRKKIKFIPPDEQSVVADRSFKLGFDTSSVGFTEDSEGSMYLSSSLDDESDDARPQVPARTRKALVKRKRNAEAYNSPERNQRNDINKKMRTLQNLLPNSHKDDNESMLDEAINYMTNLQLQVQMMTMGNRFVTPSMMMPLGPNYSQMGLAMGVGMQMGEQQFLPAHVLGAGLPGINDSADMLRFLNHPGLMPMQNSAPFIPTENCSPQSVPPSCAAFPNQIPNPNSLSNLDGATLHKKSRKTNR
The following text describes a protein:
Function:
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
Sequence:
MSVEEVTQKAQALSVGDNEERKTVLTDSKDFDLKHPLNSKWTLWYTKPPVGDNESWSDLLRPVTSFTTVEEFWAIQNAIPKPRELPLKSDYHLFRNDIRPEWEDEANSRGGKWSFQFKVRNPPIDDLWLRALLAVIGESIDEDESEINGVVINVRRSGFKIGLWTKSVRQAPLSKVGAKFKAVLQLDDSDTLEFFAHSSANDKNAKPALVL
The following text describes a protein:
Function:
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSLQAIQFQRGDKSQVSVRVLDQLLLPYVSRYIPIQTVDDGFAVIRSMQVRGAPAIAIVGVLSVLVECQLLCNEDFVAVQAFYDLSSYAAFGRTMRMRLAHLLGSRPTAVNLSHALRDVERLLDSATSLSQFRDRMYDYACELLDMDVANNVRMGDNGARFLLDALIAEGFDGSFAVLTICNTGSLATAGYGTALGAIRSLWQHAEAGLTAPKKQKASACAPRMTHVFPLETRPYNQGSRLTAYELLHDAIPATLITDSSVAYRIQTSPVPIKAAFVGADRIARNGDTANKIGTLQLALVCRHFGIRFFVVAPRSTVDGTTAAGTDIPVEERCPDEFRVVTGAAAGATGDPTTASVAIAPRDMPVWNPAFDVTPHAYIDAIVTETRVFTKDAAGNFDLDELFT
The following text describes a protein:
Function:
Member of the two-component regulatory system CseB/CseC involved in the stability of the cell envelope, through activation of transcription of RNA polymerase sigma-E factor. CseC functions as a membrane-associated protein kinase that phosphorylates CseB in response to changes in the cell envelope.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRGFFRQRRSVSPPGHPYDRTGPGEHAGPGARTGPGGRPRVLGVRGLRARGIRTGLRWKLSAAIALVGALVAIALSLVVHNAARVSMLDNARDLADDRVLIAQRNYELSGRQNFPNAQIDDPALPPELRRKIDAGRRATYVSERPDGVTDIWAAVPLKDGHVMSLHSGFTDRSADILSDLDQALVIGSIAVVLGGSALGVLIGGQLSRRLREAAAAANRVASGEPDVRVRDAIGGVVRDETDDVARAVDAMADALQQRIEAERRVTADIAHELRTPVTGLLTAAELLPPGRPTELVLDRAKAMRTLVEDVLEVARLDGASERAELQDIMLGDFVSRRVAAKDPAVEVRVIHESEVTTDPRRLERVLFNLLANAARHGRSPVEVSVEGRVIRVRDHGPGFPEDLLAEGPSRFRTGSTDRAGRGHGLGLTIAAGQARVLGARLTFRNVRPAGAPAHIPAEGAVAVLWLPEHAPTNTGSYPMLPDRSKSGASSSARDMSREASQGMSRKP
The following text describes a protein:
Function:
Non-covalently bound to the neck of the phage capsid and mediating attachment of the viral particle to host cell-surface polysaccharide. It displays endorhamnosidase enzymatic activity, hydrolyzing the alpha-1,3-O-glycosidic linkage between rhamnose and galactose of the O-antigen polysaccharide.
Subcellular Localization:
Virion.
Domain:
The active site involves residues located on two different subunits.
Sequence:
MTDIITNVVIGMPSQLFTMARSFKAVANGKIYIGKIDTDPVNPENQIQVYVENEDGSHVPASQPIVINAAGYPVYNGQIVKFVTEQGHSMAVYDAYGSQQFYFQNVLKYDPDQFGPDLIEQLAQSGKYSQDNTKGDAMIGVKQPLPKAVLRTQHDKNKEAISILDFGVIDDGVTDNYQAIQNAIDAVASLPSGGELFIPASNQAVGYIVGSTLLIPGGVNIRGVGKASQLRAKSGLTGSVLRLSYDSDTIGRYLRNIRVTGNNTCNGIDTNITAEDSVIRQVYGWVFDNVMVNEVETAYLMQGLWHSKFIACQAGTCRVGLHFLGQCVSVSVSSCHFSRGNYSADESFGIRIQPQTYAWSSEAVRSEAIILDSETMCIGFKNAVYVHDCLDLHMEQLDLDYCGSTGVVIENVNGGFSFSNSWIAADADGTEQFTGIYFRTPTSTQSHKIVSGVHINTANKNTAANNQSIAIEQSAIFVFVSGCTLTGDEWAVNIVDINECVSFDKCIFNKPLRYLRSGGVSVTDCYLAGITEVQKPEGRYNTYRGCSGVPSVNGIINVPVAVGATSGSAAIPNPGNLTYRVRSLFGDPASSGDKVSVSGVTINVTRPSPVGVALPSMVEYLAI
The following text describes a protein:
Function:
Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
Subcellular Localization:
Mitochondrion intermembrane space. Cytoplasm.
Sequence:
PGLAAAIPAPPESQEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALGFKI
The following text describes a protein:
Function:
Deamidates N-terminal Asn and Gln. Component of a targeting complex in the N-end rule pathway (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKFGCVQFFPKLGKVNENIVHLRQLLDQHSEALQSVKLLVFPEMCLTGYNFKNSESIQPFLENVTSNHCPSIQFAQEVSEQYRCYTIIGFPEFQNSNGISTLYNSTALISPKKELLNVYHKHFLFETDKSWATEGKGFSFEPCIPELGPISMAICMDINPYDFKAPFEKFEYANFILRELEHQQMVSSNVSRPIICLSMAWLVSDDKVIDASLPDIKNLHYWTTRLSPLINSNTDAIVLVANRWGKENDLNFSGTSCIMELSQGRAILHGVLKAAENGIVVGELEK
The following text describes a protein:
Function:
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MGARHGPPGGLMHRLQVGELAPTMRLGPQETRHLHVLRLRPGERVQVFDGRGGEAVAVLSELDAGHALLHLDPAAAAHSRGAEYPQPVTLAIALLKGDKLADVVRAATELGAARIQLLITAHAEARDIGAQKLVRLRRIAGEAARQSERRIVPDVLEPVPLTKLTWEGQLLTAHPGSQERLTDLLTWDAPLTVLSGPEGGLSTAEVEHLTRQGARLITLGPRILRAETAPLALLGAMAATGV
The following text describes a protein:
Function:
Exhibits phosphohistidine phosphatase activity.
Sequence:
MSALESVAEVQIDPDGVFKYILLSVTAGKSEQHRVIVRGTKSAEYHNHIFEKVNPEIQALGLECKCLGGGKIEHNSKDKKIRIFGESTGYGKADHSVAAEKLKKAYSDYEVTWSDDKK
The following text describes a protein:
Function:
Transcription factor. Recognizes and binds to the consensus sequence motif 5'-AATTAATTA-3' in the regulatory elements of target genes, such as glycoprotein hormones alpha chain CGA and visual system homeobox CHX10, positively modulating transcription; transcription can be co-activated by LDB2. Synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1. Required for the establishment of the specialized cells of the pituitary gland and the nervous system (By similarity). Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1.
Subcellular Localization:
Nucleus.
Domain:
The LIM domain specifically interacts with the POU1F1/Pit-1 POU domain and is required for synergistic interactions with POU1F1, but not for basal transcriptional activation events.
Sequence:
MLLEAELDCHRERPGAPGASALCTFSRTPEIPMCAGCDQHILDRFILKALDRHWHSKCLKCSDCHVPLAERCFSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVCKRQLATGDEFYLMEDSRLVCKADYETAKQREAEATAKRPRTTITAKQLETLKSAYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGSSKSDKDSIQEGQDSDAEVSFTDEPSMADMGPANGLYSSLGEPAPALGRPVGGLGSFTLDHGGLTGPEQYRELRPGSPYGIPPSPAAPQSLPGPQPLLSSLVYPDTNLSLVPSGPPGGPPPMRVLAGNGPSSDLSTESSSGYPDFPASPASWLDEVDHAQF
The following text describes a protein:
Function:
Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MVFNLENEKDKKVLALSNFLIDNNILDHNELNSLIERIESIYFNKYIEEKVFLFAITISRPLTIDIWNALYEGFNELNEGFKADNESFKLTITFKENEPFFKSKNSFSSVTIAIIKDYFHSFFSKDKKYKILIEQELSNPNFLSYENDELKAQCQTKELTEWLVQKSKSFIFWMNNAGFKNFNFIALYPIDKNESKLKVKAVTVSQYDKQFETKVFATEFIPIHKINQQIDDVKIIGQIFELKTHESLTGKKTLNIYVTDFQLGGSLILKWSYTDEKKIEGITIGNWIKAHIQVERDPNTQILYGIVREINPVEIPNNYKRLDLSKQKRVELVFHTKMTAFDGINDIEEYAQFAKERGWKAITVTDKDNIHIYPKFYEVAKKYDLKAIYGLEFNLTDDHIKIVHNPDNTKLSDATFVIFDIETTGLHGRYDDVIEFSARKIKNNSEIDHQQFFLKIDKPIPKTITEITKITDEMLEGGIDQQQGLEKIRNYLDDCVMVAHNGINFDLPFLQTQFEKYNIKPLTNPLIDTLCLSWALNPLFSSHTLSNICSKLKLEFDDERLHRAEYDTEALKKVFFYFKKQLKEMGINTLTEIDQNLNKKCQIDLMKRVFTNTAIVYVKNQRGFQNLYEMLSIALTDHNANRPLVLASSLAKFRKSFLLTENPVQGDIFKAALTKPINELEKAIEKVDFVLISQPNAYLGYTLREGLKKELINDAIKLVIKTATKLKKLVAVASDAYFIHPWENEYYKAIVCAKGLGGKWHRHFNNKEKEQTVPEVFLHTTDEMLKRMSFLGEDIAYKLVVENTNKIVKLLDLNELVPTKNKLYPPVMQDSNQKLIDKTWKQAEKRYGKNLPKLIKERIEKELNAIISNGFGIVFWISHLLVEQSVKDGYFVGPRGSIGSSLIANLIGISEINPLAAHYLCEQCHYFEVSDSVDDGYDLMIRDCPKCHEKASFKGDGHNIPFATFMGFSGDKIPDIDLNFSSEYQAKAHDYVRKLFGVNNTFRAGTIATVAEKTAYGYARNYFEIIKRVDLATTAEIERFKQKLIGIKRTTGQHPGGIMIFPSDHSVYEFTPCGFPADDVESEWKTTHFEYDALGDAILKLDILGQDDPTMLKHLADLTKINPQNIPHFDKNLISMFSSNKPLNLKPGIVDEVTGAVGIPEFGTKFVRKILEQTKPKDFADLIRVSGLSHGKNVWADNAQKLIKSNRLTLRDVIACRDDIMLYLINKGMQAKDAFEIMEKVRKGIKVNAKEVSLMQNCGVEQYWINACLKINYLFPKAHAAAYVLMAWRIAWFKLYHPLSYYACLLSFKLKEHDINGFEKGYEFIKNRLDELNKLYRIKKIKPKEAELLTSYEVYLEMMARNIKLQQISIQNSNARMFVEHNGVLIAPFITIPGMGEAVASSIVEARNEKPFASLNDFKKRTKITKKHVETMEQLQLFDEFEHQDDHKLFN
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Located at the center of the tektin bundle where may function to recruit tektins or stabilize the bundle.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MQTLRQEAARPCIPSGTLEASFPAPLYSDDYLSLEGSRWPPAIRQATRWKYTPMGRDAAGQLWYTGLTNSDAWEAWYNLPRAPASPFREAYNRWHSCYQHRECSMPSAYTQHLRETAWHDPIVPAQYQAPSTRWGSALWKDRPIRGKEYVLNRNRYGVEPLWRASDYVPSLSAPQRPPGTTQNYREWVLEPYCPSTCQRSPPSLTPTPR
The following text describes a protein:
Function:
Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases.
Subcellular Localization:
Golgi apparatus, trans-Golgi network. Membrane; Multi-pass membrane protein.
Sequence:
MLPLSHKDSEYKPGIKLVNKIKTWMTTIIYDESSRNIFMFLMLNLSFAFVELIWGIWSNSLGLISDSFHMFFDCTALLAGLAASVVAKWKANDRFSYGYVRAEVLAGFINALFLLFIAFFILSEAVERLVEPPAVKHERILVVSVLGFIVNLVGIFVFHGHGHHGHSHGHDHGHGHSHGHSHGHDHGHSHSHSHGHDHSHDHDHSHDHDHSHKHGDSHDHGHTHHDHPPEASQSQILHSVFLHILADTLGSAGVIVSTLLMQFFGWMIADPICSLMIGILIAISVIPLLQDSVGILMQRTPRSLDNKLHGCHQRVMQIEGVYRIHEPHFWTLCSDVMIGTIKVQIAPGANPSYIQSQVHGIYSQVGIRQLYVQIDYPAV
The following text describes a protein:
Function:
May play a role in the pathogenesis of cholera. Hap nicks and activates the A subunit of cholera enterotoxin and related enterotoxins.
Subcellular Localization:
Secreted.
Sequence:
MKMIQRPLNWLVLAGAATGFPLYAAQMVTIDDASMVEQALAQQQYSMMPAASGFKAVNTVQLPNGKVKVRYQQMYNGVPVYGTVVVATESSKGISQVYGQMAQQLEADLPTVTPDIESQQAIALAVSHFGEQHAGESLPVENESVQLMVRLDDNQQAQLVYLVDFFVASETPSRPFYFISAETGEVLDQWDGINHAQATGTGPGGNQKTGRYEYGSNGLPGFTIDKTGTTCTMNNSAVKTVNLNGGTSGSTAFSYACNNSTNYNSVKTVNGAYSPLNDAHFFGKVVFDMYQQWLNTSPLTFQLTMRVHYGNNYENAFWDGRAMTFGDGYTRFYPLVDINVSAHEVSHGFTEQNSGLVYRDMSGGINEAFSDIAGEAAEYFMRGNVDWIVGADIFKSSGGLRYFDQPSRDGRSIDHASQYYSGIDVHHSSGVFNRAFYLLANKSGWNVRKGFEVFAVANQLYWTPNSTFDQGGCGVVKAAQDLNYNTADVVAAFNTVGVNASCGTTPPPVGKVLEKGKPITGLSGSRGGEDFYTFTVTNSGSVVVSISGGTGDADLYVKAGSKPTTSSWDCRPYRSGNAEQCSISAVVGTTYHVMLRGYSNYSGVTLRLD
The following text describes a protein:
Function:
GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through Pak activation, may positively regulate microtubule nucleation during interphase. May play a role in the regulation of cytokinesis (By similarity). During embryogenesis, promotes proper muscle morphogenesis and proper guidance and targeting of subsets of myotubes. Required for the recruitment of Pak to muscle attachments in the embryo, probably indirectly through pix/dPIX. May be important for brain development.
Subcellular Localization:
Cytoplasm. Synapse. Cell junction, focal adhesion. Cell projection, lamellipodium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the leading edge of growing myotubes.
Domain:
The coiled coil region may mediate dimerization.
Sequence:
MCFASSIIEAHRKLFIAPPDLDHSDPATPTISTRSKMPRGKSRLQTEVCGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNWEPSVLNFVNSLNAHGANSVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNLTFVLKPSLQDDDDGNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKLSTPLHMAAKFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLLDAMYDVTDRIITFLGGKKPDHASGRHMIIPDANGADISEQLKIARGKLQLVPNKMFEELVMDLYDEVDRRECEAIWSTSTLNADHATVPFLPANPFLSATRNQGRQKLARFNRAEFTGLLTDVLVDAMRRQNMANLRPMDAPVAGHQSLQSLPYANNSMLLGSFEQGGHDPNLSDDEPIYDPVASDDDYAPVPPMAQQAIVHTPPRSANSHNEMETLRKQLNDYKSEINQLKNVVQMLSSENTQLKSKFSSASNNSVYDEPLRIDLSLSSPDTEHEPLSLPEGGTANGESGSSNDSSNQSTIKRPASMYERRLVPNVAKGNTDIRNTTSMYQMAGDGKPFGEEVKVRSDLVTRRLKELIRAMQPVPEDQKQSIAPHGELIRSAVTDLIALYANLPPNASDPSRETLKLLTRQNILIQHECENLQKAIEADDKQAIQKNTLEVRDCAFHIASAIKTLVLQFY
The following text describes a protein:
Function:
Involved in chromosome segregation during meiosis. Promotes efficient recombinational repair and functions in the protection of the genome from spontaneous and induced DNA damage like mutations and gross chromosomal rearrangements (GCRs).
Miscellaneous:
MISCELLANEOUS: Present with 414 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEYEDLELITIWPSPTKNKLCQFIKQNLSKEHVVTQLFFIDATSSFPLSQFQKLVPPTLPENVRIYENIRINTCLDLEELSAITVKLLQILSMNKINAQRGTEDAVTEPLKIILYINGLEVMFRNSQFKSSPQRSHELLRDTLLKLRVMGNDENENASIRTLLEFPKEQLLDYYLKKNNNTRTSSVRSKRRRIKNGDSLAEYIWKYYADSLFE
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MDPCECSKTGSCNCGGSCKCSNCACTSCKKASCCDCCPSGCSKCASGCVCKGXTCDTSC
The following text describes a protein:
Function:
Involved in chronological cell aging.
Subcellular Localization:
Nucleus.
Sequence:
MDLNLCLLCGNSIDAEGLYCSNECRIQDKATTELFSDPLKSPSLNETIDYLALNYFDLFSRRSSMCSSSNSSIYSGIYYTELKNYSVEN
The following text describes a protein:
Function:
Plays essential roles in DNA damage repair in both somatic and meiotic cells. It is important for postsynaptic events following pachytene in meiosis. It is also required for DNA cross-links repair and is involved in double strand breaks (DSBs) repair.
Subcellular Localization:
Nucleus.
Sequence:
MQNGKIKPENLLRRSPTNRKLTTGCEILDGCLRGGISCDSLTEIVAESGCGKTQLCLQLSLCTQLPISHGGLNGSSLYLHSEFPFPFRRLHQLSHTFHQSNPSIYANYNDNPCDHVFVQNVHSVDHLFDIMPRIDGFVGNSKTRFPLKLIVLDSVAALFRSEFDNTPSDLKKRSSLFFKISGKLKQLASKFDLAIVITNQVTDLVETSDGLSGLRIGNLRYLYSSGRRVVPSLGLAWANCVNSRFFISRSDGSIVKDRSEKDENCSSSVSRSAKRRLDIVFSPYLPGSSCEFMITREGICAVQA
The following text describes a protein:
Function:
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
MQSGIAASQELKSALGNLITSTSQRGLLATIQNETIIPGASISSSSSSFLSDLSALDTHVTPNAALYILLRLADDLSSPNKSLVAITYVPNAAPVRQKMLFASTRLTLVRELGGEHFAESVFTTEAAELTSEGWQKHLAHEAKENPLTSEEQSAKDLRDAEALESRGTRGQGLVQSGKLAMRVDDGVVDALKKLGGGSGENLVQLRMDGGSESLQLVSSTTSSPGQISKELDDKEPRYAFYRHSDDAGSIVFISTCPSGAKIRERMLYAASRGNVVSLAQGEGGLTVAKKLEATNPDEVTETVILEEFKVEEKEEKKGFAKPKRPGRR