lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
[Cardiolipin synthase (CMP-forming)]: Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions; [Mitochondrial hydrolase]: Activity is dispensable for viability.
Subcellular Localization:
Mitochondrion; [Cardiolipin synthase (CMP-forming)]: Mitochondrion inner membrane; Multi-pass membrane protein; [Mitochondrial hydrolase]: Mitochondrion.
Sequence:
MLHTINYRSWHLAARQLGRSTFRKFTTESSTKSPIADVCFAFDSIDGVLIRGGRGLKEGTKTLKFLQKNNIPFILLTNGGGMHESVRAQRLSKTLSVSLTEDDFCQSHTPFRALADKYKHVLVLGGKDNSVRETAEKYGFKSVINELDVIAKLGTPFWPFTSFNEEDIKDAKDFDVTRPIEAVFTYVDPVRLGLDLQLVMELGQSKNGVLGTVSKTANEGPDIYFSNADLIWPNEYPLPRLGQGAFAICCESVFKELTGKDLRNTKYGKPHKLTYDYAKNILMKKHKTLGITNPPKEIFMVGDNPESDIRGANNYGWTSILVRTGIFQGDNSPKYSAKHVSDNVWEGVRWALSKHVPAAKLNKSMGEVRGFHTSSRVLNTVTKSNNSKPIQRPLRENIFTLPNLLTFSRLLSAPLIAYLYIYDYTKAAACFFLYAGFTDLVDGYIARKFDLGSIAGTVLDPLADKTLMTCLTICLAVRETMPLTLASLIIGRDVLLVSAVSYLRYKSLPAPKTFRRFFDFAIPTTELKPTRISKWNTALQLLLLGLLITEPILPFDASFAKSPLFYIVGCTTIASGASYCISRNTFRNIGKSKLQ
The following text describes a protein:
Function:
Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA3 forms heteropentameric neuronal acetylcholine receptors with CHRNA5, CHRNB2 and CHRNB4. CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (By similarity). CHRNA3:CHRNB4 or CHRNA3:CHRNA5:CHRNB4 play also an important role in the habenulo-interpeduncular tract, modulating the mesolimbic dopamine system and affecting reward circuits and addiction. Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake. Also expressed in the urothelium where it modulates reflex bladder activity by increasing intracellular calcium through extracellular influx and basal ATP release (By similarity).
Subcellular Localization:
Synaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus. Note=Interaction with UBXN2A/UBXD4 promotes translocation to the plasma membrane.
Sequence:
MGVVLPPPPLSMLMLVLMLLPVASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSTEEDAPKTRNFYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFLQPLMARDDT
The following text describes a protein:
Function:
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway.
Sequence:
MDHTEGSPAEEPPAHAPSPGKFGERPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTSLTFTYTPEPGPRPHCSAAGAILRANSSQVPPNESNTNSEGSYTNASTNSTSVTSSTATVVS
The following text describes a protein:
Function:
Beta-1,4 N-acetylgalactosaminyltransferase involved in the biosynthesis of Sd(a) histo-blood group antigen. Catalyzes the transfer of N-acetylgalactosamine (GalNAc) group in a beta-1,4-linkage from UDP-GalNAc to the galactose residue of NeuAcalpha2->3Gal-R to form Sd(a) glycan epitope GalNAcbeta1->4(NeuAcalpha2->3)Gal-R. The Sd(a) epitope is carried in O- and N-linked glycoproteins and glycolipids, including O-linked core 1 structures on GYPA/glycophorin, SLC4A1 and SLC29A1 in erythrocytes, N-linked glycans attached to the Tamm-Horsfall glycoprotein UMOD/uromodulin in renal fluids, O-linked core 3 glycans on mucins in colon and neolactosides in gastric mucosa. Confers protection against influenza A virus strains that attach to NeuAcalpha2->3-carrying host receptors. Modifies N-glycan chains on host receptors and prevents virus entry into cells.
Subcellular Localization:
[Isoform 1]: Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein. Cytoplasmic vesicle membrane; Single-pass type II membrane protein. Note=Partially colocalizes with EEA1 and LAMP2 in early endosomes and lysosomes, respectively; [Isoform 2]: Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein.
Sequence:
MGSAGFSVGKFHVEVASRGRECVSGTPECGNRLGSAGFGALCLELRGADPAWGPFAAHGRSRRQGSRFLWLLKILVIILVLGIVGFMFGSMFLQAVFSSPKPELPSPAPGVQKLKLLPEERLRNLFSYDGIWLFPKNQCKCEANKEQGGYNFQDAYGQSDLPAVKARRQAEFEHFQRREGLPRPLPLLVQPNLPFGYPVHGVEVMPLHTVPIPGLQFEGPDAPVYEVTLTASLGTLNTLADVPDSVVQGRGQKQLIISTSDRKLLKFILQHVTYTSTGYQHQKVDIVSLESRSSVAKFPVTIRHPVIPKLYDPGPERKLRNLVTIATKTFLRPHKLMIMLRSIREYYPDLTVIVADDSQKPLEIKDNHVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFNEETKIEVLVDVLEKTELDVVGGSVLGNVFQFKLLLEQSENGACLHKRMGFFQPLDGFPSCVVTSGVVNFFLAHTERLQRVGFDPRLQRVAHSEFFIDGLGTLLVGSCPEVIIGHQSRSPVVDSELAALEKTYNTYRSNTLTRVQFKLALHYFKNHLQCAA
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MASDDVPDDDLFGPSNLEYQQTTAFSTIKPPTFDSLPVPSPSLGKRPYEQRHGPPPRQNYKAHNGPRNLVPPSNSYLGSTFPSYLGNLTPGPGAPPHQFPGPHHMAPGFPPHAPVYSGFLQGPGEPFSGPGRPDAPGMPPYDQHPHKAPGAFPPMPPGPPAFAPPFVPPPLPPGAPPAGAQPFLQQGLPMPPHLQPPENGAGEGPAQQLPDRPLPGLGEVAAEMTLGPPGHADPELTGACPNYEAPQEVACLSRTWNGRVYFDERCLRRLKAPPIGADLNEGYDTFVEKVQNENGFGDLLAAVRYRKVHLGDVQFVTYRNNLNKILGTAYDRNKSWEMGVHRRGGTVYLDVHQGEEREQTEREKRMTYWGYSFEALMTESKMPEATTPKGSHNSDSFAETPPAKSPVDANVEFCAILRTKLGAHRIVMGAEIDCYDRGPDGKKRYVELKTSKVLVNENTVRTFERHKLLSFWIQSFLASVPKILVGFRDDTGRLLKTESLSLGDIRNRVRSKEYWTGTTCLIFADRVLTWLYGNVIDGCDYVLSFNHRDGQLVLKRTDGCPLVITEHVKALRQRT
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein. Note=Enriched at crista junctions.
Sequence:
MVNFYDDVDESKSHGEFPLIPVVLQNSSELSVRTIPTGNEIIESVHLTKWLRKYRNALASQLDRYEKGWQSKIANFRLQVQHVINYSRKNIFNVDSENKHTVVPGSLIALGAFFAGSIAVNRSNWGAKRLIFGHKSSILEKLCTSLPSRILLPWVLAAATFKYWAPQTSQNLVNATENDLLPADFVKSYHNTWKRIYEEGYVAKKCDLKRQIDQTLQKNIRYAREQLYEKLEQA
The following text describes a protein:
Function:
Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation (By similarity). Possesses ATPase activity. May negatively regulate mitochondrial fusion.
Subcellular Localization:
Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein. Note=The majority is localized in the cytoplasm and a small amount is associated with mitochondria.
Sequence:
MSAEREATEAATVAAAAEARAETGAGEGAPSQPPTVEVASDPQPPPAPEASASASAPPLRCLVLTGFGGYDKVKLQSRPAVPPAPGPGQVTLRVRACGLNFADLMGRQGLYDRLPPLPVTPGMEGAGVVVAVGEGVSDRKAGDRVMVLNRSGMWQEEVTVPSAQTFLMPEAMTFEEAAALLVNYITAYMVLFDFGNLRPGHSVLVHMAAGGVGMAALQLCRTVENVTVFGTASASKHEVLKENGVTHPIDYHTTDYVDEIKKISPKGVDIVMDPLGGSDTAKGYHLLKPMGKVVTYGMANLLTGPKRNLMAMARTWWNQFSVTALQLLQANRAVCGFHLGYLDGEVELVSRVVTHLLALYNQGHIKPRIDSVWPFEKVADAMRQMQEKKNIGKVLLVPGPEKET
The following text describes a protein:
Function:
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ).
Subcellular Localization:
Nucleus.
Domain:
The VWFA domain interacts with the KBM (Ku-binding motif) found in a number of DNA repair proteins; The N-terminal and C-terminal regions are not required for binding to DNA or for degradation of the protein with only the central region being required for these processes.
Sequence:
MTTTIPLKEAVVVILDIGLGMTSKDSDGTTTTTSSIEDALRSVTLLYQQKLIYGKKDQLGLVLIGTKGTKNNLQDDGYQHITVVSDIEEPSIETLKYLENLAPGESKGDVIDSLIVAMDMLIRKTENKKYQKRIFLVTNARDPINTEDLSIVRDQFKKIDVKLNIIGVDFLEEIEENNMDTSNNNKNKSLKEKNEIFLREFAESVDGVLVPVKQALEMMSFFRSQSVMTRTSFRGALEITPELKIPVWGYLKMKQQLLPSLKKISSIAQQQIEQQQQQQQQQNKNKNNEDNEDNEEGKPNITLDVNQEVSYYSITDPDNEILKPDLLKGYKYGKSLIPFSKIDEDQLKYSSSKCLKVVGFTDRKSIPIYYNMGNTEVFVSQPGDKQSEEALSSFIHALVETDQVMVVRYVKTMNGSPYLGYMIPHVKSDYVCLYYNHLPLADDIRQYQFPPISPKNPLTRKSNIPNAEQLEATQQLIDSMDLMKSEFDEDGDPIQMLKPRFTYNPLLQHFYQCLHHRSLHPNTQIPKLDPIIAEYINPDQIIMNKSKQSIKNFADKFPLTKTTVFSKTPAISGGNTNGTTSNTNNTMIGGVKYHWKDGMLIGEEINLDSYVTDDGSEAKKRKVNDFSEFSLDKLVSGYVTEVGTINPVQNFKDMLNRRDMDLVDKAITLMKERILQLVNDSLRDQYYQKAFECIKELRVGCIRESEAEQFNGFLKDMRSLFQSKKRDDFWQYITADVTSILGEKSINLITQDECDSSEVTQEELDQFLDKKVKQFNPPPITNVNTDSVDDLFDQIE
The following text describes a protein:
Function:
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
LLGLLLWAPLLWAPPPPVRGRRHGVYWNGSNPRFLQDDYSIQVSINDHLDIYCPHYSAPTPWAESFTLFMVDEEGYRGCSETPGAFKRWECNKPFAPFVPVRFSEKIQRFTPFSLGFEFRPGETYYYISVPTPGSAGRCLKLRVSVCCRASTPEPLTEVPNSQPRGRGGPEGDAGSPRDAAPIPQRSRTRLVALAVVAVLWV
The following text describes a protein:
Function:
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
MIINILYPVCVTMIIVVLAIRSISNFKNGSSTVTLTSSLDNSDGAGSSNAGGADTMVFDSLVNSLIFLAVIILSTTIMVVLYKFKMMKALYAWLMGTSILLLGVFGGFLFLVMLAYLNLGLDYITFVIVVWNFSVGGIVCIFWYAPKIMNQGYLISISVLLALFFSRLPDWTTWGILTVVSIYDIFAVLCPGGPLKILIETAQKRGEEIPAMVYNASVYVESNVDSQSESSQKRKQSIRLGLGDFVFYSVLIGKAASYEIITVFTVFISIITGLFLTLFLLAVFKKALPALPMSIILGIGVFFLTFKILIQYIYFLGSNQIFV
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system.
Sequence:
MTTNTKFSEDIVPLSDLKINPGRVVSQVDKTHRPVLLTSRGRGVAVVQSVRDFEADAEERAFLKAVVQGLVDIEEGRTVSLADARKRLGLD
The following text describes a protein:
Function:
Acts in the cytokinin signal transduction pathway that regulates spore germination. Required for the maintenance of spore dormancy. Does not appear to act as a cytokinin receptor. Probably undergoes ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, which is followed by transfer of the phosphoryl group to a conserved aspartate residue in the receiver domain.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEKSEQTNSFESSNNNNNNIDSNINNNLENNNNKNNNNNNNNNNNNNNNNNNIENSIDKNNKEDNSLVGVNSHRKHRTRLKSKKGNKHETKKEIDYKDLLIKLPHNAVSNFNSLENESSDNLTPPPPINSSPLPLPLSLPLPLSLPLPLPLPLPLPLPLPPNKENIEINMEDIIIPENKIKNKNNNNNIDINNNNNNNNEKQTSIIEMEDLDKLKQPKINEGSTGKKGKSHFFSFLQRGDKTNSSILKSSEQPTHKKTKTNINTPPDYPIHYFGHHKRFSSSSDEGSDNSKSQHSSVNTPTLSRHNIDSLPESQQSQKQSQQQSQQPQQQNKTKQIQQTILNNNNDNLNEVTPIKKSSLPTLEVSPIQSNIINNQTTEKHNSGGFTALTSASAMNHQNQRRYREHHQINHQQQQQQHHRHYHHHINSGGSSGSSDKFDYVSATGLSTKNGFNPKSLDVDHFPISDKRNNINIQAPSTPVQSRNYPLFTTQSPKNANSASKSKNKLKNLKRKIASSITGNNPSGISSSAFNHSFSSWNNNNSVYTGGNSGGGSGGGGSGGGGGGGGGGGGIGTPSSFLDDNNNLNNGENFKNSNSYNNNNGSNRSISHDEWLRQFYHKHLERYEKTKAVDYLIIKPWNFISWILRPSRIANYQSKILYRRAYILNFLNLVLFVVYLLSTILSSNEWFIFAPGILLSVIYFFLGKINNKMYLIAFLTISTAVAINITSIIYDLTHTRPTDKLIFSWDLLVMIMVPLLFPSIVYSIVILISVAVTYIGLGIYVQSSHNFYLLDAYDSFGELLRSIIIVFVILMFYTILSSVDLKEIERKESRIQSLFRISNEALVVHKDGLITDANPAFESMFQIKLQDLLYPIQSGIWEFLPALEGMFEPGASKLFDNPDMGVIETTGIDSSGRTFQVEVRTNKATYDGEPVDVISIIDITGRKQLMEADYALRKAEAANEAKVIFLTTVSHELRTPINGVLASADILERTTLDSTQKEFLNCIKLSGNYLLDLINDILDYSKIEAGKMEIIKYDFSILKMLDNSIRIVSKNIYEKGLDLCIFIDPNVPVIVNGDQRRIKQILLNFLSNSIKFTNHGQIIIRVKLESDDSTHSLIKFDVEDSGIGIKTEHLNQLFASFSQIDSGNSRKYQGTGLGLSISKRLCKMMGGDVKVKSEFGVGSTFSFTIPCGIPNTTTRFSLQSLGSAIYMGEDIQGINKPIGKKKYGASGVVGIVIDSNKYTRKSISQYFAILKISCVDFENKKEFENYLSTLATVDQTTNPQVYLVITSIIDINQLTTNGLPRDRIYHWILMESPNEERKLPLEFENRFVKPAQFADIVRCLYKIDSINFFIEQMAGSPYKASKDLQSGGSSNESGDGGRSLSGGGGGVGSNGNGNGGGGLDSNISPSELSSSEHQLISTPLSDVNEFEDINLINQSLSGLGPSAKVLNSTYFNGLSQSSKIYNNNNRNGVGIGNHHHDHYYQHRHHHSLPPEEIDYDESPFLFLNKPIRKVYHSQPSTPVTNGIALMDSSSKSPSIPSSSSASASALSPNSRHSNELGNGKTTQSFVFSPTSRKFSLNDSFNPSISTIVLPQVSYSPSMQGGNFPINMESVYKKIESHNNNFKRSESKPSTPTFLSNQPSPATSNSPQLLQSPTTSTTGSINLSPHRSPNIRLPLEVRSGSLSSLKPLREDEELESISDDHTSHLKGSSHSINQQIPSTIQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKPQQQQQKPTTTTTTTSTQLPQNIEKTTTTTTTSTTKPTATSSSSSSSKTTKTQQQQHHPTTTTTTKSEKIEKTAAATTSEKIEKILLVEDNFVNVKIFSKLLKDSGYIFDVAHNGVEAVECVKKGAYDLILMDCQMPEMDGFEATTAIRELEKSNLIESPPSKKHSHVVIVALTANSGYKDKQKCLSVGMNDFLQKPIKTSDILIQMIKKHLN
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MQNSAHVDEYSSSINGNASNDSEVAIEQTTDFSTEIMNVIEMEQSPDGSPNVNEENTEENEISNVELPVTDTEAQFPPEYEKFWKAVENNLQDFTGWVYLLQYVEQENHLLAARKAFDKFFTHYPYCYGYWKKYADLEKRHDNIKQSDEVYRRGLQAIPLSVDLWIHYINFLKETLDPDDPETNNTVRGTFEHAVLAAGTDFRSDRLWEMYINWENEQGNLREVTTIYDRILGIPTQLYSHHFQRFKEHVQNNLPRDLLSSEQFIQLRRELASVNGHSGDDGPPGDDLPSGIEDITDPAKLITEIENMRHRIIEIHQEMFNYNEHEVSKRWTFEEGIKRPYFHVKPLEKAQLKNWKEYLEFEIENGTHERVVVLFERCVISCALYEDFWIKYAKYMENHSIEGVRHVYSRACTIHLPKKPMVHMLWAAFEEQQGNINEARSILRTFEECVLGLAMVRLRRVSLERRHGNMEEAEQLLQDAVKNAKSNNESSFYAIKLARHLFKIQKNLPKSRKVLLEAIERDKENTKLYLNLLEMEYSGDLKQNEDNILTCFDKAIHGSLPIKMRITFSQRKVEFLEDFGSDVNKLLDAYDEHQILLKEQDSLKRKAENGAEEPDEKKVHTEDASLASTQMIDGDIQANQAAYNYSAWYQYNYQNPWNYGQYYPPPPT
The following text describes a protein:
Function:
May selectively reduce calcium-activated potassium channel (Slo) currents by reducing the number of Slo channels in the plasma membrane.
Sequence:
MSIADVEYEYVVLKINGYDISHLSRYEAVQKFLQSKETLVVEIRRQKHNALDLELKHGSNAKISKVDNPGELSVLTDKSAEGTITAASASQQINCPSSTSLKEIETKTPVVLTLRARSHEDRLGSLQAASKETQTQSVVGTDVLKDNDLVNTITDNFIEHEHHLFEQCLEPEIDIEEVTLVKGVEQSSSNQIGLIVTSSGIQQSSTDTNKGDILGNVLEHSEDVFISGVQPESIAYRDGRLRQGDQILRINGLDVKNQEELETQIARSSTSVTLLVSRILYPEDDDDEDIHFEYANTFLPDDYTNVVDKLDKVLLTHVKSLEELSNKSAMQSDECYHIPEKNSSDSNVKISSLAKNIIEQSTKSCSKIKLRPNANLDYKKKFNLPLSQEEVHLQYEYDESEHIYETIPEDSESEPVYCSPYQRSNDKTSIGCSSPIASRPAESLERTMQQQTQRVAQWLGLKPQYQKTRQTLVGRPPPLKLVQQPTCSRVFTLRSTLTNTSASSSSGVAYSSYGQNNVVTGNAAAPGEEVDNSSSAYNTGDSNNSASPHQNTTNPDEAIATGRKLDSTVIDSPNDHLDATGVSTMLLLPFGKSGRIGLCSSNLPTAYVSERYTNVGSENEIHPLKSDIEILRVKPTDDSYSHCPQFNAPNLSSYHFVSSQEVANRCHISTSLQKNATLLNGESAEEIPMVWKVKRRPDGTRYIVKRPVRNRPQVALRKNMRYNEVTTTEDDTISEVKIGRYWTKEERKRHIERAREKRHHQTQQQQQ
The following text describes a protein:
Function:
Proton-coupled transporter that delivers pathogen-associated or danger-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes or tissue injury. Has selectivity toward muropeptides that contain the amino acid diaminopimelic acid (DAP-type peptidoglycan muropeptides) including Tri-DAP and tracheal toxin (TCT), common in Gram-negative bacteria and Gram-positive bacilli. In the context of immune recognition of skin microbiota, shuttles bacterial muropeptides across the endolysosomal membranes into the cytosol for recognition by NOD1, triggering MYD88-dependent secretion of IL1A and neutrophil recruitment in a pyroptosis-type inflammatory process. To a lesser extent and redundantly, transports muramyl dipeptides derived from most bacterial proteoglycans, eliciting NOD2 receptor activation and downstream inflammatory responses. Postulated to function as a dominant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages. Selectively imports cGAMPs derived from pathogenic bacteria such as 3'3'-cGAMP thus providing for differential immune recognition of pathogenic versus commensal bacteria. During tumorigenesis may transport extracellular tumor-derived 2'3'-cGAMP across the plasma membrane of M1-polarized macrophages to activate the anti-tumoral stimulator of interferon genes (STING) pathway. The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable).
Subcellular Localization:
Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Localizes in acidic vesicles likely late endosomes and/or endolysosomes.
Sequence:
MSPEVTCPRRGHLPRFHPRTWVEPVVASSQVAASLYDAGLLLVVKASYGTGGSSNHSASPSPRGALEDQQQRAISNFYIIYNLVVGLSPLLSAYGLGWLSDRYHRKISICMSLLGFLLSRLGLLLKVLLDWPVEVLYGAAALNGLFGGFSAFWSGVMALGSLGSSEGRRSVRLILIDLMLGLAGFCGSMASGHLFKQMAGHSGQGLILTACSVSCASFALLYSLLVLKVPESVAKPSQELPAVDTVSGTVGTYRTLDPDQLDQQYAVGHPPSPGKAKPHKTTIALLFVGAIIYDLAVVGTVDVIPLFVLREPLGWNQVQVGYGMAAGYTIFITSFLGVLVFSRCFRDTTMIMIGMVSFGSGALLLAFVKETYMFYIARAVMLFALIPVTTIRSAMSKLIKGSSYGKVFVILQLSLALTGVVTSTLYNKIYQLTMDMFVGSCFALSSFLSFLAIIPISIVAYKQVPLSPYGDIIEK
The following text describes a protein:
Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. Exit from the ER requires UNC93B1. Endolysosomal localization is required for proteolytic cleavage and subsequent activation. Intracellular localization of the active receptor may prevent from responding to self nucleic acid.
Sequence:
MGPYCAPHPLSLLVQAAALAAALAEGTLPAFLPCELQPHGQVDCNWLFLKSVPHFSAGAPRANVTSLSLISNRIHHLHDSDFVHLSNLRVLNLKWNCPPAGLSPMHFPCRMTIEPNTFLAVPTLEELNLSYNGITTVPALPSSLVSLSLSHTSILVLGPTHFTGLHALRFLYMDGNCYYMNPCPRALEVAPGALLGLGNLTHLSLKYNNLTEVPRRLPPSLDTLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCRECPKNFPKLHPDTFSHLSRLEGLVLKDSSLYKLEKDWFRGLGRLQVLDLSENFLYDYITKTTIFNDLTQLRRLNLSFNYHKKVSFAHLHLASSFGSLVSLEKLDMHGIFFRSLTNITLQSLTRLPKLQSLHLQLNFINQAQLSIFGAFPSLLFVDLSDNRISGAATPAAALGEVDSRVEVWRLPRGLAPGPLDAVSSKDFMPSCNLNFTLDLSRNNLVTIQQEMFTRLSRLQCLRLSHNSISQAVNGSQFVPLTSLRVLDLSHNKLDLYHGRSFTELPQLEALDLSYNSQPFSMQGVGHNLSFVAQLPSLRYLSLAHNGIHSRVSQKLSSASLRALDFSGNSLSQMWAEGDLYLCFFKGLRNLVQLDLSENHLHTLLPRHLDNLPKSLRQLRLRDNNLAFFNWSSLTVLPRLEALDLAGNQLKALSNGSLPPGIRLQKLDVSSNSIGFVIPGFFVRATRLIELNLSANALKTVDPSWFGSLAGTLKILDVSANPLHCACGAAFVDFLLERQEAVPGLSRRVTCGSPGQLQGRSIFTQDLRLCLDETLSLDCFGLSLLMVALGLAVPMLHHLCGWDLWYCFHLCLAHLPRRRRQRGEDTLLYDAVVVFDKVQSAVADWVYNELRVQLEERRGRRALRLCLEERDWLPGKTLFENLWASVYSSRKTMFVLDHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILRPAAYRSRYVRLRQRLCRQSVLLWPHQPSGQGSFWANLGIALTRDNRHFYNRNFCRGPTTAE
The following text describes a protein:
Function:
Septins are GTPases involved in cytokinesis that assemble into filaments and form a ring at the cleavage site. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation (By similarity).
Subcellular Localization:
Prospore membrane; Peripheral membrane protein. Bud neck. Note=Present at the bud neck during cell division. Probably interacts with phosphoinosides such as phosphatidylinositol 4-phosphate or phosphatidylinositol 5-phosphate (By similarity). Localized to the leading edges of the membrane sacs that form near the spindle-pole bodies and gradually extend to engulf the nuclear lobes that contain the haploid chromosome sets, thus forming the spores.
Sequence:
MKSKGSRLSTDCPVEFPKIVSGFAEEVKIRRQSSQGQYAVDSHPPKSPELKHRRQRSSSFVNGKCRNRDLPLLDNKKAQEINTNSHGQDIGIKNLPRQRELLNAKNGIDFTLMVAGQSGLGKTTFINSLFSTSLIDDDIKENKPIIRYKSIVEGDGTHLNFNVIDTPGFGNNMDNAFTWRTMVNYIDEEIRSYIFQEEQPDRTKMVDNRVHCCLYFLRPSNKGIDTLDVVTMKKLAKRVNLIPVIAKSDLLTKEELKNFKTQVREIIRVQDIPVCFFFGDEVLNATQDIFQKYPFSIIASNEYIFNEKGEKVKGRQYKWGAVDIENEKYCDFKILQKTIFDWNLIDLVESTEDYYEKCRSEMLRTRLLKARDCLTTKSVDITEEQRKFLEEEMNFDEIEENKLKNYKCYEIINKTVMDKVATEWDPEFITRQLEAKKKFNELSNREISKFRDWKKSLFMEQENFNQEIEQLNHKLENLQLECQDLEYKLLIGKSSNSHSTDSATLVNVHIKR