lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Sequence:
MRYRKGARDTAFLVLYRWDLRGENPGELFKEVVEEKNIKNKDAYEYAKKLVDTAVRHIEEIDSIIEKHLKGWSIDRLGYVERNALRLGVAELIFLKSKEPGRVFIDIVDLVKKYADEKAGKFVNGVLSAIYKAYITSSKEEKPSLKSE
The following text describes a protein:
Function:
Possible non-essential role in spermiogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MATGGGVVGGGRGPGAPRARPRPPGRVRPPGAAPPPAGARTQRPRERGRGGRVPGRAGRRTKMDAKKPRKCSLTSFPSLKAKKKQNLSPGKVESKPLAQAQKPPSKIKNLRMTRFLHKNPNTSITSLPFVDTKGKKNMVNFPCIGNKILLKPPLLYQDNQSHNQLPASELKASELPFHSSIKTKDPKPEEKPPRKHKVPLTAAEALKCFKNQLSSYEQSEVLGYTELWFLGLEAEKLHMTPEKFNKMSFDDEHGSYMKVLHDHIAYRYEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDNTYNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFQGFSLSIVRRFTLSVLKCLQMLYVEKIIHCDLKPENIVLYQKGQVSVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEMEQLACIMEVLGLPPTHFIQTASRRQTFFDSKGFPKNMTNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHEPRNLKPRYRPQTLRKPSLCLPSEAQKDKVQGHHRLGIKEVIIKEETSSVTAKQVQNSGDQWSSLQHAAEVVQLPQLTETSRKPEAVVGPEESKTSPGKQSKNSSPKNMNILPPIV
The following text describes a protein:
Function:
Cleaves internal linkages in 1,3-beta-glucan. May contribute to plant biomass degradation (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MPPGAKVPQAEIYKTSNLQGAVPTNSWESSILWNQYSLPIYAHPLTFKFKAEGIEVGKPALGGSGIAYFGAHKNDFTVGHSSVYTFPDARADKISDFAVDAVMASGSGSIKATLMKGSPYAYFVFTGGNPRIDFSGTPTVFYGDSGSQCLGVTINGVNYGLFAPSGSKWQGIGTGTITCILPAGKNYFSIAVLPDNTVSTLTYYKDYAYCFVTDTKVEWSYNETESTLTTTFTAEVSVKEGTNKGTILALYPHQWRNNPHILPLPYTYSTLRGIMKTIQGTSFKTVYRYHGILPNLPDKGTYDREALNRYINELALQADAPVAVDTYWFGKHLGKLSCALPIAEQLGNISAKDRFISFMKSSLEDWFTAKEGETAKLFYYDSNWGTLIGYPSSYGSDEELNDHHFHYGYFLHAAAQIALRDPQWASRDNWGAMVELLIKDIANWDRNDTRFPFLRNFDPYEGHSWASGHAGFADGNNQESSSEAINAWQAIILWGEATGNKTIRDLGIYLYTTEVEAVCNYWFDLYKDIFSPSYGHNYASMVWGGKYCHEIWWNGTNSEKHGINFLPITAASLYLGKDPNYIKQNYEEMLRECGTSQPPNWKDIQYMYYALYDPAAAKNMWNESIVPEDGESKAHTYHWICNLDSLGLPDFSVTADTPLYSVFNKNNIRTYVVYNASSSAKKVTFSDGKVMTVGPHSMAVSTGSESEVLAGDLNGDGKINSTDISLMKRYLLKQIVDLPVEDDIKAADINKDGKVNSTDMSILKRVILRNYPL
The following text describes a protein:
Function:
Involved in protein export. Participates in an early event of protein translocation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHTLLSVLLIIVSILMIVMVLMQCSNSSGLSGAISGGAEQLFGKQKARGIEAVLNRITIVLAVLFFVLTIGVTYFNL
The following text describes a protein:
Function:
Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome membrane. Cell projection, cilium, photoreceptor outer segment. Note=Associated with peroxisomal membranes; anchored by PEX26 to peroxisome membranes. Localized at the base of the outer segment of photoreceptor cells.
Sequence:
MALAVLRVLEPFPTETPPLAVLLPPGGPWPAAELGLVLALRPAGESPAGPALLVAALEGPDAGTEEQGPGPPQLLVSRALLRLLALGSGAWVRARAVRRPPALGWALLGTSLGPGLGPRVGPLLVRRGETLPVPGPRVLETRPALQGLLGPGTRLAVTELRGRARLCPESGDSSRPPPPPVVSSFAVSGTVRRLQGVLGGTGDSLGVSRSCLRGLGLFQGEWVWVAQARESSNTSQPHLARVQVLEPRWDLSDRLGPGSGPLGEPLADGLALVPATLAFNLGCDPLEMGELRIQRYLEGSIAPEDKGSCSLLPGPPFARELHIEIVSSPHYSTNGNYDGVLYRHFQIPRVVQEGDVLCVPTIGQVEILEGSPEKLPRWREMFFKVKKTVGEAPDGPASAYLADTTHTSLYMVGSTLSPVPWLPSEESTLWSSLSPPGLEALVSELCAVLKPRLQPGGALLTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHSSRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAAC
The following text describes a protein:
Function:
Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis.
Sequence:
MDINNNIDNITNSNNNIEKNNNINNFDNNNNNNNILYISSSESNNNNNINSSNSSSNNTNNSNNSSISNNNNNNNNNNNNNNNISIEGNTANNSDIKVGTSLTNSIKSFKKLFNNQKSNNNNNNLQVNHFQQSQSLPPSSNTSPTFSSTSPIIIVSDNTNIESLDLEINSNNSGSIGSNNSGDNNNINMNYKSKSLSLNYSILRPLCDTDNISNNNNNNNNNSNNSNNNNNMSSSDNNNNSNSNNTTNGGQLKRNNSSNNNNRYSIGGPLKMSNSSDFNDYLLNNNILYNINQPNRKTPPPNLMSVLKNSFTQYTPPSTTLTSPTSTRNPNRLSTNLSNVTNISSSTSSSSSSLNANNNTNNNNQQLQQQQQQQQQQQLQQQQQLTKSYSVSNLMRSQSSSSSSQSPLIQQSDQVTFDYDYIYRRFLRSRSELTLPSWDNAQYEGDFDTEIQDTLTRALSNGNLPSDNKRQSLHLSTESTTSNNNNNNNNNNNNNNNNNNNKSKTDDTTNSATTTTTTTTTTTTTTTTNSTTTTTQLNNGKNLIGLVYNDKDEVIAGERDKIIGLFTDISKVTGTQFLEEFLFTYHYYMTSVDLLENLKGRFNNPLMDQAAQSISILEENHDKVKIEQLSTHIRLRVINVIKKWIENHGYAFATDINLYQMLVDFIDGDVMSFSQRWGQYLKKAINDSGCLLRYIAVNVKEASSKQLREIISLDNLDAISKLMSQSLQLKERKKGLKVIKNSFTGNEAVEWLINKFNLDSKDEALETLSKMLQSNLIFHHSKSGSSFSPSSSSSSTTTTTTTSSSSSSSNTTTANMASSSSATDNSSSGGVVTSSSSSSSSSSSSPSNGNGTTAITSTSLPNSISSSNSTSILTSLVVNSNSSGIANGSSTPSIPSSVTSPLTNSKSTLNSTPSSSSNSFTFKDKSTSIYYFIFENINFPEPIVPKTFFSSPNSTFSITFLDIHPVEIARQLTLIDYELFKKLSPTDFYHTAWSKPDAKEKVPNLINFINRSNTVSYWVATEILSSSNIKHRVSVLKRFITIAEILRKFHNWNTLTGILMGLNLGSIQRLKKTWESIDKKQLDSLQNLINLTSERLNYSNYRKEMSTPTYPCLPFMAVYLKDLYFIEENPDYLENGYINFEKMKMISKVLIEIKRYQTEQYWLKKIDAIENILKSVVLTDKDLYKASHMIEQPQRTMTVGSNLKAQSFLTTTTTTTTTNNLNNNNNNNNPNNNNNNNNNSANNKSSPSPSPSSSPITSSPISSLTINNNNTISSNLSASTDSSINTKKKSSFLMFGKK
The following text describes a protein:
Function:
Has a role in chromosome segregation. May provide a dynamic connection between kinetochore microtubules and kinetochore chromatin.
Subcellular Localization:
Nucleus. Note=Associated with chromatin.
Sequence:
MFWRLGQGFGFQSSSAIEAILDKPEDEINLKELLEENGVLDECKSHNPKLLEYLCKPEVLSQLIDYILEVDETEIPSADGGYEEPEHTRLSYIASEILSSDVWSICEACVENKTLMVKLWSFLDSEGPLNPLQASYFAKVNEHFLDKKTEETVAFIQSIDNFVEKILRHAETSAIMDLLLKFISMDRCNTAIGIADWLYSQGLIQSLLRLLSPYVDPDVQFTVADVIKAIIAISANSNEPGVIGPNSLSRELVSRQTITTLTDYMTDSKAPHSATSLINGVSIVIELIRKNNSDYDVTPVLQMPLDTHPPTTRDPIYLGTMLRLFAEKIPVFQKILLKPSTESDLMPTSFGKIKPLGFERFRICELYAELLHCSNMSLLSDPNGEAMVMQRDHLRDYLFRHNSCARDLVMSDEDDDDSTFSDKNSKDFKETEDMNGAEDMHGRAPQITKDNLNLTTTDSPMSEAEPVSEEEYKDVMETAKALHHGDDDAASDTSYEPLPESVIEDAKKLPVIGDFLKIEFIQNNVIPTILDHFFDYPWNNFLHNVVYDVVQQVLNAPMDKDQNYALAVDMFKQGKITEKIVYGQELNDKKVAKPSGFRAGYMGHLTIIADEVVKFVEHYSSTFDQELLNLINDEKWQNFVNKTLVETRNRDNQLLGGLEPSMVGYLEDMDEGEMLDANNLPEMQFALEQELESNSSDDDVVEVHRELSHNSSSNDEDDGNDEDPLSREMSRRLSFESANDSDQDNRDHFAQYMSQQISDNNANQFSSSDEDDDDDDEVVEWVSRGNENKYPRSNFFINGSDREDFSDSEEEDGNDSSDDDRGFAEEEYSDGLVLNHGK
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.
Sequence:
MATKGTVSGVIANMVTLVVDGPVAQNEICYISTGGDRLMAEVIKVVGSHVYVQVFESTRGLKVGAEAEFTGHMLEVTLGPGMLSKNYDGLQNDLDKMDGVFLKRGQYTYPLDKERIWHFVPMVSAGDKVVASAWLGQVDENFQPLKIMAPFTMNGTATVKTIMPEGDYKIEDTIAILTDEEGNDIPVTMIQKWPVKRAMTNYKEKPRPFKLLETGVRVIDTLNPIVEGGTGFIPGPFGTGKTVLQHAISKQAEADIVIIAACGERANEVVEIFTEFPELVDPHTGRKLMERTIIIANTSNMPVAAREASVYTAMSLAEYYRSMGLKVLLMADSTSRWAQALREMSNRMEELPGPDAFPMDISAIISNFYGRAGYVKLNNDETGSITFIGTVSPAGGNLKEPVTENTKKVARCFYALEQDRADKKRYPAVNPIDSYSKYIEYPEFEEYIKDHINDEWIGKVNELKTRLQRGKEIAEQINILGDDGVPVEYHVIFWKSELIDFVILQQDAFDEVDSVTPMERQEAILNMIIDICHTEFEFENFNEVMDYFKKMINVCKQMNYSKFKSEQYEGFQQQLKELIAERSVK
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MKTAKPPAAEAPSGPSGSNRRAQPVRQTRINPPRTSSLNRTNSFPNGPTPEQPIDIFPAVTHFTDAITALPKELVRHFTLLKEVDAKIFAPEATLFELVDAALKAPVPDRTRSVTDGNNSVAPASTPMSAQNSTSGRVASNANPATVPPSITDSAHAAVFDPTNLPRRHLFRQAAWKIQEMLVSLEEKNHVISTANDALHKQLSRIEEIWPHLENEFSDEAKWGSTTHWAYAENRVPKTNHKEAERSRREGAATLSAAAQQIAEEAAARSSDRKQALAAKKNNKGQATEPEADSKAQETTKKGPGTGKSRKHQAEATPVGLGIANGTPTNGTGPSKRRKVEKEPKANGSAPMERAMSSVFGNGTAKSKTTASPRGSPAPDGATPTGPTTKKRKALPSGSTQAKKSRTNAANSPSVAASPLLGSLPDTKAGRNSPVPLPPRPASSRARGNSTASTTLPIQQRPATATTNKPNGITPAVAEAVPQSKSTSDAKAPKEADPPAPTPAKTEAAKPETEIKPPVPPEPVANASTSKKENSKAVTAPAEEPETKKRTNSIVSQTAILPPPISTTVTTTKSGRASKPSTPATGTFAEAANATTTTARSRPSRNSTNQSDKDSNSTSGKDTFGNSTTTTSGTTTSKRSHKKGASSVSAVAVSVALQDEKPGKSAAASDEKKDAASDENSGRPTTSGRGKGSAAAHRDSKAERGSERDRGGERDTKTETNHGHGHGRRGTATAAAARAQQQQPQHQQRQEEEDDDDDDDDVDADEQRYCFCNGISYGEMVACDGDGCPREWFHLECVGLKVAPKGNAKWYCEDCKKRLRASGR
The following text describes a protein:
Function:
Serine/threonine-protein kinase essential for spindle-assembly checkpoint signaling. Plays a key role in the recruitment of the checkpoint proteins bub-3, mdf-1 and mdf-2 to unattached kinetochores. mdf-1 recruitment is independent of bub-1 kinase activity. Has a role in the correct kinetochore localization of the spindly-like protein spdl-1. In addition, during meiotic anaphase I, controls the recruitment of hcp-1/2 and klp-19 to the ring-shaped domain formed between chromosomes. Involved in chromosome alignment, chromosome homolog segregation and spindle assembly. In association with bub-3 at the kinetochore region of chromosomes, promotes the onset on anaphase independently from spindle checkpoint signaling and promotes the formation of stable end-on bipolar attachments of chromosomes. Plays a role in nuclear envelope breakdown. Required maternally during embryogenesis and in the zygote for the postembryonic development of several tissues including ventral cord neurons, gonad, intestine and seam cells.
Subcellular Localization:
Cytoplasm, cell cortex. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores during prophase and metaphase. In metaphase, also localizes to a matrix-like structure around the spindle. In anaphase, localizes only to unattached kinetochores which is kln-1-dependent. Also localizes in a ring-shaped domain between kinetochores, during anaphase of meiosis I which is air-2 and kln-1-dependent and between sister chromatids during meiosis II, which is kln-1-independent. Localization to the kinetochore is dependent on bub-3 and on knl-2.
Sequence:
MSHIRVAFAPLDTNPSTCGLETFATQIETLSQMMTAEEMKAELYDCVRRILREQKFDQIRENEAMLRLYKVMGRSSTNLKGRGIYEQLFKKDHFTGSLKFYLQWAEECGKDQMLEEFKDVLKLARDRLSERIEMTAIESGFRDLVDEYFNGESGDMFTRPDETMDLFRFNAGSKKKRRSSVCFLQHNVPINNSGKAAFGPKTKTDLRQACIDRPNYHGISIEEFRFAKWKDTFGEDVDDDYRKRKDSGVVFVKHQVIDTDRQAREEVENRFNANLNPRRRHLSPVSEKTVDDEEEKRSRIYSPLVATKDAHRPALRSKIENPPATVTLSSDTKSASEKDVSDSDDADDDERLKIMTAGRKDGNPPDRSTSISSNYSTASARTSKSGAGLDLMAENKCLEAHAMFSDTVHLASEKTMVLGDDSVFVPERSLATTQIVTDFSVLCDPDPTMTITQERPKKVSNGLNVVYDEAAEPEESQKVEESEVQPEIVLVSPVTQTSPATMFNDIYDDEIEFGFFKPSRGNFVTSTPAQGVHLVNIDEYFGNKEEESTHEQEAPVFVAPTSSTFSKLTRRKSLAANQAVQPSVTESSKPERSDPKDSSIDCLTANLGRRLSIGADEIPNLTENNESEITGCKIRRRSEIIKQGDINPWDETLRKKLMCLVRPPQNMHEFQERAPKIQALRDCEVSGEKLHIQTLIGQGGYAKVYRAVTDDQRTVAVKYEVPSCSWEVYICDQMRNRLKDRGLELMAKCCIMEVMDAYVYSTASLLVNQYHEYGTLLEYANNMKDPNWHITCFLITQMARVVKEVHASKIIHGDIKPDNFMITRKIDDKWGKDALMSNDSFVIKIIDWGRAIDMMPLKNQRFKGRAGTEAFDCPEMVDGRSWTYQADYFGFAATMAVVVAGKYAQLTGASVGDYSLNVDIKRRNILRDACYDVINRFLNIPSCDSLPDWNILIKSFSEIWNEKFEASGWRQAVSKFNEACDLAANQK
The following text describes a protein:
Function:
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome. This function in autophagy requires its cholesterol-transfer activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle, autophagosome. Note=In lipid-poor conditions localizes to the ER membrane and is recruited to endoplasmic reticulum-plasma membrane contact sites (EPCS) in response to excess cholesterol in the PM (By similarity). Localizes to distinct EPCS than GRAMD2A and ESYT2/3.
Domain:
GRAM domain binds phosphatidylserine in the PM and mediates protein recruitment to endoplasmic reticulum-plasma membrane contact sites (EPCS) in response to excess cholesterol in the PM; VASt (VAD1 Analog of StAR-related lipid transfer) domain, also known as ASTER (Greek for star) domain is a sterol-binding domain.
Sequence:
MFDTTPHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPSTQSLGSRNFIRNSKKMQSWYSMLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLGTPKEVGDVIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVDSQPDASSSQTVTPVAEPPSTEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLAALLPDLSGRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQCKFTDVTLSPWSGDSKCHQRRVLTYTIPISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYCILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEEGGKDARGLLSGLRRRKRPLSWRAHGDGPQHPDPDPCARAGIHTSGSLSSRFSEPSVDQGPGAGIPSALVLISIVICVSLIILIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFPQTATEWAEILALQKQFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVSDPPFDTQPRPDDSFS
The following text describes a protein:
Function:
High-affinity zinc transport protein.
Miscellaneous:
MISCELLANEOUS: Inhibited by Cu(2+) and Fe(3+) ions.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSNVTTPWWKQWDPSEVTLADKTPDDVWKTCVLQGVYFGGNEYNGNLGARISSVFVILFVSTFFTMFPLISTKVKRLRIPLYVYLFAKYFGSGVIVATAFIHLMDPAYGAIGGTTCVGQTGNWGLYSWCPAIMLTSLTFTFLTDLFSSVWVERKYGLSHDHTHDEIKDTVVRNTAAVSSENDNENGTANGSHDTKNGVEYYEDSDATSMDVVQSFQAQFYAFLILEFGVIFHSVMIGLNLGSVGDEFSSLYPVLVFHQSFEGLGIGARLSAIEFPRSKRWWPWALCVAYGLTTPICVAIGLGVRTRYVSGSYTALVISGVLDAISAGILLYTGLVELLARDFIFNPQRTKDLRELSFNVICTLFGAGIMALIGKWA
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum.
Sequence:
MFPQHWEPPADLAALEMADKNTQKDQKEKKVKKERKERKNKKEDVAEKVVKKPRKHCSRNPVLARGIGRYSRSAMYSRRAMYKRKYAAPKTRIERKKKEKVPATISKPVGGDKNGGNRVIKIRKMPRYYPTEDVPRKLLSHGKKPFSQHVRRLRSSITPGTVLIMLTGRHRGKRVVFLKQLASGLLLVTGPLTINRVPLRRTHQKFVIATSTKVNLSGVKIPNHLTDAYFKKKRLRKPKHQEGEIFDTEKEKYEITEQRKADQKAVDSQILPKIKKIPQLRGYLRSVFSLSNGVFPHKLVF
The following text describes a protein:
Function:
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Sequence:
MNKLFICLIITIIFSNIVVIYSKPFNFDRSYQEWRKPNPKPDIHTPEYYDASYLKDLNTIKDTPDQFLVTDLPGLSDNITFYSGLINVNETSNGNLFFWFFPANVSNPLDAPFLIWLNGGPCCTSSDSVFIETGPLRFNSDGKTFHLNPWSWHNAANVLYIDQPVGTGLSFTYGDSVTNDLEINQNFYQFLQSFFTIFSDYSKLPFYMSGESYAGHYIPHMADYILSMNSQTSTNKNLIPINIAGIAMGNGYTHPPVQIASYATFGYNIGIIGINQVNEYNQLNELCQEQLKLNNYNSDECANVFNQLLSDSGTNTTSMVNMYDYRLNDPTAGDNWPQPGLGFETSYLQRADVRAAIHANPNLPDVWTECNMTCNAALTNQDESSLFLLPILLKQIKVLIYNGQFDIICNHVGTTQYLDGMEWDGQQSWNNASRFTWNSFNNEGTATVTAGYGKTFENLTFVLALGGSHMYPMDMPASSYDMIKRFLNNESFADLPQSFGFESPAPKQPVPLTLPIWIGICVGGSAFSLIVGILITFLIMRKSNKHYYRVIQ
The following text describes a protein:
Function:
Protein sialyltransferase specifically expressed in goblet cells that plays a key role in intestinal host-commensal homeostasis. Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins. Catalyzes the formation of the sialyl-Tn (S-Tn) antigen, an antigen found in intestinal goblet cells. Protein sialylation in globlet cells is essential for mucus integrity and is required to protect the intestinal mucus against excessive bacterial proteolytic degradation.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MTRYCRGLSQRQAFLLLTVLALLFILLFVVKDPRAKDSRCQFIWKNDASAQENQQKAEPQVPIMTLSPRVHNKETTSVSSKDLKKQEREAVQGEQAEGKEKRKLETIRPAPENPQSKAEPAAKTPVSEHLDKLPRAPGALSTRKTPMATGAVPAKKKVVQATKSPASSPHPTTRRRQRLKASEFKSEPRWDFEEEYSLDMSSLQTNCSASVKIKASKSPWLQNIFLPNITLFLDSGRFTQSEWNRLEHFAPPFGFMELNQSLVQKVVTRFPPVRQQQLLLASLPTGYSKCITCAVVGNGGILNDSRVGREIDSHDYVFRLSGAVIKGYEQDVGTRTSFYGFTAFSLTQSILILGRRGFQHVPLGKDVRYLHFLEGTRDYEWLEAMFLNQTLAKTHLSWFRHRPQEAFRNALDLDRYLLLHPDFLRYMKNRFLRSKTLDTAHWRIYRPTTGALLLLTALHLCDKVSAYGFITEGHQRFSDHYYDTSWKRLIFYINHDFRLERMVWKRLHDEGIIWLYQRPQSDKAKN
The following text describes a protein:
Function:
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN (By similarity). Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity). Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (By similarity). Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation (By similarity). Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by initiating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: TRAF6 catalyzes initial 'Lys-63'-linked-polyubiquitin chains that are then branched via 'Lys-48'-linked polyubiquitin by HUWE1. 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination. Also participates in the TCR signaling by ubiquitinating LAT (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet. Note=RSAD2/viperin recruits it to the lipid droplet.
Domain:
The coiled coil domain mediates homo- and hetero-oligomerization; The MATH/TRAF domain binds to receptor cytoplasmic domains.
Sequence:
MSLLNCENSCGSSQSESDCCVAMASSCSAATKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALVDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAALVAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSLIPDSGYVSEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSTYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPDLLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDSGV
The following text describes a protein:
Function:
Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MADDLPTEFDVIVIGTGLSEAITAAALTRIGKKVLHVDKNDYYGGQWAAFTFDKLLAWIEKARNLKSGEKLPPYIQDTDTNQKRLLLSNDVLTTLNLEVECYCDKAPEIMKDDRSTDGDEIYNIEEIEMAQSQRDADNDESSESPQSQDPSSEDVEKTPNQHDADKSENSKSPQLQAPSSGVADQVGSNQAIRDRTAKEFTYQDLKDLWRRFSIDLLPKLLLCRGPLVELLIKSKVARYVEFKCVTKILTYRGNRLVQVPCSRSEVFSTNLMSMLEKRMLMKFLSFCIEYEKHEDKFKEYEQRPFSDYLKSWRLSEDLQHFIIHCIAMVEKNVTTIEGLAAAQCFLQSLGRFGETPFLWPLYGVAELPQAFCRLCAVFGGIYCLRMTVPSLIIDETSNRCTGIITDEGQKISCSNVIIDSSYLPSALLSDEPDKEKSISRAIFITNKSIYPTETDEVILFSLPSSDLSYLIRGLEISAGSMACPEGLYIVHLTCLMKSNAKDDLQEVTDSLFNFEENSGKDGNKKPKVLWCTYFNQIGYNVKERLPSNILTVDPIDSEMSFKSIVAKAENMYHNICPNEEFIPSPPDPEDIIIDDTSPQKNGKETGENAGFSGCEENEEIRMEDNEDENTSTTSSLKPNEM
The following text describes a protein:
Function:
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Sequence:
MSPQKRVKNVQAQNRTSQGSSSFQTTLSAWKVKQDPSNSKNISKHGQNNPVGDYEHADDQAEEDALQMAVGYFEKGPIKASQNKDKTLEKHLKTVENVAWKNGLASEEIDILLNIALSGKFGNAVNTRILKCMIPATVISEDSVVKAVSWLCVGKCSGSTKVLFYRWLVAMFDFIDRKEQINLLYGFFFASLQDDALCPYVCHLLYLLTKKENVKPFRVRKLLDLQAKMGMQPHLQALLSLYKFFAPALISVSLPVRKKIYFKNSENLWKTALLAVKQRNRGPSPEPLKLMLGPANVRPLKRKWNSLSVIPVLNSSSYTKECGKKEMSLSDCLNRSGSFPLEQLQSFPQLLQNIHCLELPSQMGSVLNNSLLLHYINCVRDEPVLLRFYYWLSQTLQEECIWYKVNNYEHGKEFTNFLDTIIRAECFLQEGFYSCEAFLYKSLPLWDGLCCRSQFLQLVSWIPFSSFSEVKPLLFDHLAQLFFTSTIYFKCSVLQSLKELLQNWLLWLSMDIHMKPVTNSPLETTLGGSMNSVSKLIHYVGWLSTTAMRLESNNTFLLHFILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSILNQLCFIMHRYRKNLTAAKKNELVQKTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKGIYIDPEILEKTGVAEYKNSLNVVHHPSFLSYAVSFLLQESPEERTVNVSSIRGKKWSWYLDYLFSQGLQGLKLFIRSSVHHSSIPRAEGINCNNQY
The following text describes a protein:
Function:
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
Subcellular Localization:
Cytoplasm, cytosol. Preautophagosomal structure.
Sequence:
METDLNSQDRKDLDKFIKFFALKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAKKALAGQLPAVGRSMCVEISLKTSEGDSMELEIWCLEMNEKCDKEIKVSYTVYNRLSLLLKSLLAITRVTPAYRLSRKQGHEYVILYRIYFGEVQLNGLGEGFQTVRVGTVGTPVGTITLSCAYRINLAFMSTRQFERTPPIMGIIIDHFVDRPYPSSSPMHPCNYRTAGEDTGVTYPSVEDSQEVCTTSFSTSPPSQCVFTVTKAHFQTPTPVVTDTLRVPMAGLAFSHQLSSSRLSYQPAALGVGSADLAYPVVFAAGLNTTHPHQLMVPGKEGGVPLAPNQPAHGAQADQERLATYTPSDGAHCAVTPSSSEDTETVSNSSEGRASPHDVLETIFVRKVGAFVNKPINQVTLTSLDIPFAMFAPKNLELEDADPMVNPPDSPETESPLQGSLHSDGSSGGSSGNTHDDFVMIDFKPAFSKDDILPMDLGTFYREFQNPPQLSSLSIDIGAQSMAEDLDSLPEKLAVHEKNVREFDAFVETLQ
The following text describes a protein:
Function:
Involved in the biosynthesis of the antibiotic D-cycloserine (DCS), a cyclic structural analog of D-alanine, used as an antitubercular agent. Catalyzes the synthesis of D-cycloserine from O-ureido-D-serine (D-OUS). It reacts with D-OUS, D-homocysteine and beta-aminooxy-D-alanine.
Sequence:
MGILALVTDAVSLPIDYDMPPLLEACRTVGITAEVCDWEDGTVDWSRFEAVVFRSPWTWAERQAEFLAFCERVSHVTRLITPMPLVRWALDKRYLADLAAHGVPVIPTTVVAPGSDALAAVRDFLAARPEAREFVVKPTDGCYSKDVQRYQRSLAEPASRHVARLLANGSHVILQPYVESVDRHGETDLTFFDGVYSHAIHKGAMLMPDGTVHVPTLDFRQARDADEDQRAVAAAALAASVAHLGLDLPLVCGRVDLVRGADGSPMVLEMELCEPSLNLTFSEDGALRFAQALAERLKP