lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (By similarity). Fta2, fta3 and fta4 associate with the central core (cnt) and inner repeat (inr) region of the centromere.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MDNNDQISNLCLGALQLLADQPISVISNEPSEEQRNEHVLKKWENNVLRHWKILFSLFMQTCGDSVQGNAAFSILNFMTTNSLVGQLYQRLYDESNSLGFISSPLNETEHLSEENLKIESSITFTSEEIEKEKENIKSVLLPSVQSISSSLELYASKESDYRSSIEGVLADLKLARARWEIVRNVTQILLLESGISFLENKKLAYIMDLCGDREDNYSSY
The following text describes a protein:
Function:
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNA which might negatively affect its histone methyltransferase activity (By similarity). COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face (By similarity). Methylation promotes maintenance of active chromatin states at euchromatic chromosomal domains and is present throughout the cell cycle. Plays a role in telomere maintenance and DNA repair in an ATM kinase rad3-dependent pathway. Required for efficient telomeric and centromeric silencing.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
A construct containing set1 C-terminal fragment of 692-920 is able to form H3K4me; The RxxxRR motif forms an adapter helix that bridges the nucleosome and ubiquitin.
Sequence:
MDFNTSTRSKSQPVQRNNYKVLYDPELGIKENLGRKIIYRFNGVSKPPLVVRDPRLKNPIYARGIPKSGRPFLKSLQTINYDYNENSLGPEPPTQVFVSNISPLVTSEQLRYHFKSFGEVFDLDLKLNPYTGTSLGLCCISFDKRSSISVAAHSAKIAVQQANGLRFSGKPLSVVLDRDGSLCEEAFKKALNAVEKQFQEETLQKQRFEREDESSRQKLSAAMNEDIPPWRQPSKNSQTLSNGDLQHSKVQNVDQKSGFLTSSETDVPKNINDYIYLLIDDRFVPPDRVYYTDIKHHFRKFLYEKIYMNKDGFYITFNNYREASNCYRALDRTYVQNCRIKLKFHDIPSRTKEDGKKSAVRRVVLPPEEAYAEATSVVLRDLEAALLRDVKSKIIGPAIFKYLHSMPKPSVKEELQENLLVSSTSVPDVPLKIESTVGKLPSLPKFKKRVDSSKMNLSAGSKTKSKLQRRRRRRHEARPLHYQLNQMYNSSASEAESDQELLLSSGDERVERGKIGSIKSVKSDEATPVFSDTSDENDKFHRFRTKSKISKKKYEKMEVDYTSSSETESDASILSPSAAIPKSGSAIKDELISPKKEIDEVLALAPKWRINEFDETGSVYYGALPYNYPEDDVLLDLDGLQYLVKNDEDYSYLQEALKDEPLMDINDPNFWAYERKSCKFKNGDVKYGDTAILPEPKGYFRSNTSGSAKSEGYYIIPTTEKSLYLPLRNRSTIDTISHSTSRITSRMNRVNNRRLAAGVEKSQLPAEADLLRFNALKARKKQLHFGPSRIHTLGLFAMENIDKNDMVIEYIGEIIRQRVADNREKNYVREGIGDSYLFRIDEDVIVDATKKGNIARFINHSCAPNCIARIIRVEGKRKIVIYADRDIMHGEELTYDYKFPEEADKIPCLCGAPTCRGYLN
The following text describes a protein:
Function:
Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Sequence:
MSKFFRRRKFCKFTAEGVKEIDYKDLNTLRQYLTENGKIVPSRVTGTKSKYQRQLATAVKRSRFLALIPYTDNHDV
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAFIKEESEDLKIEDTFKHEDPEEQIDLILLKEESNDSEEATQPEKHPEFIPGDKSSRSSQTEKPSSQNKTESSLACKHCGEAFTRKSSLDLHMKAHMGEKPYACAECGKSFTHKGYLKTHMRSHNEESSYSCALCDSSFSRKGSLKTHMRVHTGEKPYTCAQCGKSFTRKGTLNTHMRSHSGENHHICKLCGNSFSRKGSLKAHMRIHTGEKPYECPQCQRSFTRKGTLNSHLKTHIGVTPSSKIKKSFFRRQHPKTKTEEKPFACVQCARGFKYKKNLNQHMRIHSRESCFVCQHCGRRFTSRIYLRNHLKTHTGEKPYVCTHCGKSFSLKGSIKVHMRIHTGEKPFTCEQCGKCFRHKVTFNYHMRIHSREDVFECQHCGSEFADGTELEKHVNVHLGENPFMCHFCGKTCINNGNLVIHLRVHTGEKPFVCVECGKSFTRKGNLETHVRTHTGERPYKCAECQESFVYQRELKLHSRLHSDSVKAFRCSRCSRSFRNGSSFKNHLKLHSVVRRFSCVWYDKRVALPSRVKSIADMKSYVCCSCRRRFKWLSHLKWHQRTCIVKT
The following text describes a protein:
Function:
Involved in protein precursor import into chloroplasts.
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein. Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MTSLHALSPASNIQASRCVRRALPGQARYASVLATPRLPGRRTAPSSTQNDGPSPSARPVVLARSLFDNRGKDDFGDRILASIPFLLPLLDGLPYAKFIMIQYPFVARAFAPVAPLMYIYHAFPFAPFLVFLAIYAGIVNNQGLPRFVRYHAMQAVLLDVLLIIPQVILNDLWKAPTDPLGLQAYITAYNTLFLFTSVCAAYGIASSLVGVTARLPIVAEAADVQVRD
The following text describes a protein:
Function:
Appears to play a role in translation fidelity, and may act when translation is compromised. May be a component of the ubiquitination pathway (By similarity).
Miscellaneous:
MISCELLANEOUS: Open reading frame exhibits genomic organization compatible with a translational readthrough-dependent mode of expression.
Sequence:
MQESKEPQNKFEGCQRISSSSSTLFGGTSFEEPRCGTSQGKEEDAFACNNGDHCSSITNVQEDDFVLPELLPSFEMYENLLSNIPQSSFDTYFPENPPFYEVASRNQSIPSEGESGNDMRILTGDIVGPDNHEVTVDGRRFASGPAESQIRNYDDTKGIPVENIYALPRIKTPIATELYVTKTAPKFGQLPKHESMLREYTSGDIIHGYFTVENKSTKPIKFDMFYLTLEGTTSSKTQSPFGIQKTTERILRMVDMAASWSYNHEDVNTGEDLCGFFDSIDKTSFGLPNSRILNPGDKRKKFFTFKIPNQLLDVTCKHGHFSHSLLPPTLGFDRPSSSHPELSTLKFSESLGYGRLSERGSSLWLNDSSSGSLINYSINAMIVGKDVASGRVCLMSEKKYSIRIVPFGFQNNPISREKCLKDLEDFDIEIANRLGMIEKVFSKIERAIPIHKEDIQEANRSDQLSPLRGKYEWNAVAGNTENGTLKKKH
The following text describes a protein:
Function:
Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS.
Subcellular Localization:
Cytoplasm. Peroxisome. Mitochondrion. Note=May localize to aggresomes.
Sequence:
MRSRLLLPVPHLPTIREMSEELSHGAAGQEPPASPSLDDYVRCICQLAQPTSVLDKVTAQSRPNRPSRPAWTREKRRQAESPGDSSLCVSSLQPTLPSPGTDNPLDWLFGKSQGEQADGRGRPNRTGSSDPWDVPRQMGKDTGRLCEARVPEHSLGRKPGPRHQTSDLKSWTSRKSCRALASVSSSRPSSILGTLYLHLPVIHEL
The following text describes a protein:
Function:
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Couples electron transfer from reduced ferredoxin to NAD(+) with electrogenic movement of Na(+) out of the cell. Involved in caffeate respiration.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MNVKHGTFKGGIHPPYRKESTAEVPLGFGKKPEMVIIPMSLHIGAPCTPIVKKGDTVFLGQRVGEPNGFVSVPVHASVSGKVIAVEERPHASGDRVMSVVIESDGLDTIDPSIKPYGTLEDMDADAIKKMVLNAGIVGLGGATFPTHVKLAIPPDKKVDCVVLNGAECEPYLTADHHLMTSQAEKVVMGLKLAMKSVGVEKGFIGVEDNKTDAIEALVKAIGNDSRLEVYSLHTKYPQGAEKQLIAAITGREVPSGALPADAGVVVMNVGTAAQIAESMITGLPLYKRYLTCTGDAIKNPQTIEIRIGVPFQSVIDQCGGFSSEPGKVISGGPMMGVTQFVTDIPVMKGTSGILCLTKESAKIATPSNCIHCGKCVGVCPIHLQPLNIAEYSQRNMWDKCESNNAMDCIECGSCSYICPAKRTLVSSIRVAKREIIAQRRKGN
The following text describes a protein:
Function:
May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein.
Subcellular Localization:
Secreted.
Sequence:
MWTGYKILIFFSLTTDICTETHFSQGEAEPGPRFTRNHTIFEGSRHKRAIFQGEYCRRFGCCEARDDTCVTQFYEANALCYCDSFCERDTSDCCPDYKSFCHEEKEEPPFQQPSDPEGCFRDSQHYEEGSVVKENCNSCTCSGQQWKCSQHVCLVHPELIDHINKGDYGWTAQNYSQFWGMTLEEGFKFRLGTLPPSPMLLSMNEMTASFPPRADLPEIFIASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWFLRKRGLVSHACYPLFKDQNTTNNICAMASRSDGRGKRHATKPCPNSFEKSNRIYQCSPPYRVSSNETEIMREIIQNGPVQAIMQVHEDFFYYKTGIYRHVVSTNEEPEKYKKLRTHAVKLTGWGTLRGARGKKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDDP
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MMSAKTRRTKLLELDHYEPESIIVDATGELQAIDAANEEFAQLLIDSDRENVLQPDGLVNQYEKYCRKRAQEDLDNFREDLAVDWKQEADTWALVCALLSDRYGVDDDLDDNGDPVQQVPPSVFCSDFGHSYEVSKAVREHIIVKQWLESIAPEFQPVEVRKGYYPHTSMQIRGQQRLQGVPNQWNNDNAQIVSELDPDAPSRQHRRIAPEDQSYETELLRTIYEYLRRGRLADAFHLCRACDQSWRIASMGGGAFRDDPFVDGVKDTDVGVFEGNENRVLWKAICYQIALDDNTQLYERAIYAVLAGDIKNALPACHTWEDHIWVRYHAMIESLTSKSLSDIPTPFLTNQELCLPLPHISVEPHIIFTELSKSENARISQEAAEPFHIIQAHLILDSLDMLFASLHVQLVEMERDTNTPSIFGLSSVLRFTAHLILLLRGMGISGYAENSEHVDFLLSRYIHMLHVAGKGDLIAMYVAYLPSEMQVDCYSSFLQDVDDDLQIRCALVTAGIDCMLDMPRICRMTVEKIFRRSSVMDKLEREVPLVTLCGTADTVPESDLLLIRALEWLDMDDMQLEDRLDHANLLARHFLIQGHVQSVYRLVQDIGLPIENFRVLMAKNAKLFKLGTEWLQNQSLVECLSNQAKWSFLFFQQKPQVKDDKPTHKTLEWQGKVKSLTTDTVKKMRVLLENFSAPDYLDEFDSVASQRTLEMEIIKGIYVPELVMWMHQILIQTHRIIPGNLEQSLELANLVAGLDHDGLYEQFKRSNKLGLFMRAMRESALLLLSQNKQELFSQ
The following text describes a protein:
Function:
Required for larval development. Probably by binding receptor egl-15, negatively regulates membrane protrusion from body wall muscles during larval development.
Subcellular Localization:
Nucleus. Membrane; Peripheral membrane protein.
Sequence:
MAVPAASSIVSYGGAATSNFLTTPVTPFLAGFYNSNFVTDRINSCAPYRVDRIRKQLQDEEENGYPPADDRRRGALFCRSGTWLEMLPIENPDDGSTRVKVHGTKEESSKFSIVEFVSVAMSLVSIRGVETKNFICMDPSGKLYATPSSNYSTECVFLEEMMENYYNLYASCAYGDRFNPWYIELRRSGKPRRGPNSKKRRKASHFLVVHHDLDRLRSPVPNGNDVTDLVVASLFHQPPSHPLFRQQTVTKPPNPHRISNLRAKVEMTNQAEKQRLLEEKKRRREKKKRRREDRLRKEEQIREARRQELKSLREEELRRRYQQQQQQQASTQTRYNRPQNPANPYPTYRPLPTRSTVQSPRPAYNPYWQSPVTQAPHHNSHHHHHHHPRVSSSSDPQQRHQSQQHYLAQTVSNPNRQNVNYQRYP
The following text describes a protein:
Function:
Polycomb group (PcG) protein. In contrast to other PcG protein, it is specifically required during the first 6 hours of embryogenesis to establish PcG silencing. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via a methylation of histones, rendering chromatin heritably changed in its expressibility. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3. The Esc/E(z) complex is necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSSEKVKNDNEPDDTDDSCGDESASFTTNSTTSRSKSPASSTRSKRRGRRSHKSKPKSGAAYKYDTHVKENHGANIFGVSFNTLLGKDEPQVFATAGSNRCTVYECPRKGGLTLLHCYADPDPDEVFYTCAWSYDLKTSAPLLAAAGYRGVIRVIDIEQNEAVDNYIGHGQAINELKFHPHKLQLLLSGSKDHAIRLWNIQTHVCIAIFGGVEGHRDEVLSIDFNMRGDRIVSSGMDHSLKLWCLNTQEFQHKIELSQTFSQEKSTLPFPTITKHFPDFSTRDIHRNYVDCVQWFGNFVLSKSCENAIVCWKPGQLHQSFEQLKPSDSSCTIIAEFEYDECEIWFVRFGFNPWQKVIALGNQQGKVYVWEMDPSDPEGAHMTTLHNLRSVATVRQIAFSRDASVLVYVCDDATVWRWNRRHAAAI
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSLYYSLVFAMLVCESAVFALLAVPLPMAVRRPLTRALARPFESATVQMVLKVLLGFVLLLFVDTTNRLYVVNREYERARHVEFAHGRRELLSRKFLAQRNMYLTGITLFLTFMLGQTFNLVLELLALKGATERPGATTAAGLRAEIEECEKELARLKAQADALAEDM
The following text describes a protein:
Function:
Involved during embryo development.
Sequence:
MSAVKSVSSFRLASLLRRENDPSAAMKLFRNPDPESTNPKRPFRYSLLCYDIIITKLGGSKMFDELDQVLLHLKTDTRIVPTEIIFCNVINFFGRGKLPSRALHMFDEMPQYRCQRTVKSLNSLLSALLKCGELEKMKERLSSIDEFGKPDACTYNILIHGCSQSGCFDDALKLFDEMVKKKVKPTGVTFGTLIHGLCKDSRVKEALKMKHDMLKVYGVRPTVHIYASLIKALCQIGELSFAFKLKDEAYEGKIKVDAAIYSTLISSLIKAGRSNEVSMILEEMSEKGCKPDTVTYNVLINGFCVENDSESANRVLDEMVEKGLKPDVISYNMILGVFFRIKKWEEATYLFEDMPRRGCSPDTLSYRIVFDGLCEGLQFEEAAVILDEMLFKGYKPRRDRLEGFLQKLCESGKLEILSKVISSLHRGIAGDADVWSVMIPTMCKEPVISDSIDLLLNTVKEDGPLSAMPQC
The following text describes a protein:
Function:
Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Note=Expression is concentrated at the cilium basal body but is also detected along the length of the cilium.
Sequence:
MADNSSDEYEEDNKEKKKPSQLTPQQGFSENDDDDDDDSSETDSDDDDDDEEHGAPLEGAYDPADYEHLPVSAEIKELFEYISRYTPQLIDLDHKLKPFIPDFIPAVGDIDAFLKVPRPDGKPDHLGLLVLDEPSTKQSDPTVLSLWLTENSKQHNITQHMKVKSLEDAEKNPKAIDTWIESISELHRSKPPATVHYTRPMPDIDTLMQEWSPEFEELLGKVSLPTVEIDCSLAEYIDMICAILDIPFYKSRIQSLHLLFSLYSEFKNSQHFKALAEGKKTFTPPSNSASQAGDAETLSFL
The following text describes a protein:
Function:
Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS.
Subcellular Localization:
Nucleus.
Domain:
The two fingers are functionally distinct and cooperate to achieve specific, stable DNA binding. The first finger is necessary only for full specificity and stability of binding, whereas the second one is required for binding (By similarity).
Sequence:
MDFPGLGALGTSEPLPQFVDSALVSSTSDSAGFFSSGPESLDTASSSTSPNAATAAATALAYYREAEAYRHSPVFQVYPLLNSMEGIPGSSPYASWAYSKTALYPASTVCPSHEDAPSQTLEDPDGKNNNTFLETLKTERLSPDLLTLGTALPTSLPVTSSAYGGADFPSPFFSPTGSPLSSAAYSSPKFHGSLPLAPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRPLIRPKKRMIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRKDGIQTRNRKASGKGKKKRGSSLAGAGAAEGPAGGFMVVAGGSSSGNCGEVAPGLTLGTAGTAHLYQGLGPVVLSGPVSHLMSFPGPLLGSPTASFPTGPVPTTTSTSVVSPLSS
The following text describes a protein:
Function:
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
Subcellular Localization:
Cytoplasm.
Domain:
The PRC barrel domain binds ribosomal protein uS19.
Sequence:
MSALVCVARIGAAHGVRGAVKLWTFTEDPFAIKRYGPLLSKDGKRQFEVAQAREAKDHLVATFKGVTTRDEAERLNGIELYVAREKLPATDEDEYYHTDLIGLAAVTTDGEPLGRVLAIHNFGAGDIIEIAPPKGASLLLPFSNAVVPEVDVAGGRVVVALPQEIAGDEAEER
The following text describes a protein:
Function:
May play a role in sperm development or sperm function. However, does not appear to have an essential role in spermatogenesis or male fertility.
Subcellular Localization:
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.
Sequence:
MCRTPEKPGTPQTHFRLVGRRGKTRAPNAASASGARLEPNSPRIPPGNRWVGPGKRWVGPGNRLVGSPQLLFTCCPSCASLEEESMPWVEPEPRPSPEQKPKLTKQDSATGPEWYQKSEESESEGNQPPLGPLASPRPPETPGPPALERDDAPLPEGDDASPRPSVLDDAPRLRLELDDAPLPEEETPEPRAICRHRHRCHTDCLEAPLSRAFQWLGWQVGAHPWIFLLAPLMLTAALGTGFLYLPDEEEEDLEEQYTPVGGPAKAERRFVQGHFTTNDSYRFSASRRSTEANFASLLVVSYSDSLLDPATFAEVSKLDGAVQDLRVAQEDGSQIQYQQVCARYRALCVRPNPLLHAWQVDKTLNLSSISFPIYHHGGHPLYLTGFFGGRILGGSLGMGHLLLRAKAMRLLYYLKTEDPEDSVQSKQWLTHFLDQFTNITNTLALKKIEVVHFTSLSRQLEFQATSMTVIPVFHLAYVLIILFAVTSCFRLDCIRNKMCVAAFGVISAFLAVVSGFGLLLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWHKTRLADDIPERMSNVYSKVAVSITITTITNILAFYTGVMSSFRSVQCFCIYTGTTLLFCYFYSITCFGAFMALDGKREVVCLRWLKKADPKWSSFKKFCCFPFGSVPDEHGTDVHPMNLFFRDYFGPFLTSSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEEDYFSDYGPRVMVIVTKKVDYWNEDVRQKLENCIKIFEKNVYVDKNLTEFWLDAYVQYLKGNSQDPNDKNTFMNNIPDFLSNFPNFQHDINISSSNEIISSRGFIQTTDVSSSTKKKIMLFQLRRIAEDCQIPLIVYNQAFIYFDQYAAIIENTVRNVLVASAAMFIVSLLLIPYPFCSLWVTFAIGSVIVGVTGFMAFWKVNLDSISMINLVICIGFSFDFSAHISYAFISSSQPSVNQKSIEALYLLGYPVLQSAISTILGVCVLASAKAYIFRTFFKIMFLVMVFGAAHGLIFIPVFLTFFGRFI
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Sequence:
MAAAAAMVSSAGALLAMLNESHPALKLHALSNLNAFVDLFWPEISYSVPIIQSLYEDEKFDQRQLAALLVSKVFYYLCELNDSLSYALGAGPLFDVSQDSDFVRTILAKAIDEYASLRTKAAEANDESTVLDSRLEAVVERMLDKCITDGKYKQAIGMAIECRRWDILQAAIIRSDDIQSTINYCMDVSRSFLNPREYRHEVLRFLVKMYEQLSPDYSSICQCLMMLDDSEGIAKILEKLLRSEYVNHALLAFQIAFDLVENENRAFLLKVMSQLSTPKLQPSGNIHEEVYAEEFTKIRRILFGEVSMQLSMQFLATNDKLDFIIKKIEQSVDMTNSVCHNAIIYSNAIMHAGTTANEYIMENLELLNRDSNWAKFSAMAGLGVIHRGHQLQNKSVLDIYMQHGASDGPYTAGGQRFGLGLMHLNNNEEDIKTFLRGSLSSSSVEVIQHGACLGLGLAALGNADNDVFEDLKNVLYTDSALAGEAAGISMGLLMAGTASERAVEMLDYAHKTQHEKIVRGLALGVALTVYGREEEADTLIEQMTRDQDPILRYGGMYAIALAYRGTLNSKAIRKLLHFAVSDVSNDVRRTAVIALGFVLYSDPEQTPRMVSLLSKSYNPHVRYGAALAVGISCAGSGLSEAISLLEPLTSDDVDFVRQGALIAMSMVMLQISEVSDSRVGAFRRQLEEIILDEWEETMSKMGAILATGIIDAGGRNVTIKLMSKTKYDRMTAVIGLAVFTQYWYWHPLLHFISLAFSTTAFIGLDYELNMPRFQFLSHAEPSLFEYPKPTVPITTTPVKLPTAILSTSSRRRVRPGKKENEKADSMQVDSSTEKKSEPEPSFEILDNPARVVPTQEIYIKFLPLSRYVPVKSAPSGIVILKDLQIEAYYII
The following text describes a protein:
Function:
Major methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert homocysteine to methionine. Performs 15 to 20 percent of the total methylenetetrahydrofolate reductase activity of the cells.
Sequence:
MKIVDLIDKIPNGNAFYSFEYFPPKTTVGLENLSSRITRMSRNMMPLFSSVTWGTAGSTAEVSIYLAKMLEQHHKIPACLHLTCTNVDKAIIDKALETAKEYGIRNILALRGDPPLNSDHWEGKVSEFEHAVDLVRYIREKYGDYFCIGVAAYPEGHVDSNVPELSKDPLRDIPFLIEKVEAGADFIITQIFYEPEAFIKFENFVRNHSSNALRNIPIIPAIMPIQSYGSLKRMTRLCGCSVPSSLMQRLNAAKPDDEAIKNIGVEHIVDMIKKIMDNVQGRVHGFHFCTLNLERSVALILKNSGLLTKRWKQVESEMEDEKLLRTTRKRLSLDEPAELHNQVVVPSQQPVADKSSNLFVTSKQSSVSGHKDNLTEEAPFSVSEGSGVLGRQANWDDFTNGRFGDPRSPAYGEIDGYGPTLHFPPSEALKLWGYPVDESDITSLFQKHIMSDISAIPWIDEPVEVETKTIAKYLLKLNGNSWWTVGSQPAVNGAPSADPVFGWGPKGGRVFQKAFVECFVNGKDLKDFITKWHDNPQVTYYAGNNKSEFLTNAPKDGASAVTWGVYPGREIIQSTIIAEVSFKAWLSESFQVWGEWANLYSKNTPSRKLLENCINDRWLVTVIHHDFMDKNGLWKVLEIDF
The following text describes a protein:
Function:
Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs. The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.
Subcellular Localization:
Host nucleus.
Sequence:
MDTADIVWVEESVSAITLYAVWLPPRAREYFHALVYFVCRNAAGEGRARFAEVSVTATELRDFYGSADVSVQAVVAAARAATTPAASPLEPLENPTLWRALYACVLAALERQTGPVALFAPLRIGSDPRTGLVVKVERASWGPPAAPRAALLVAEANIDIDPMALAARVAEHPDARLAWARLAAIRDTPQCASAASLTVNITTGTALFAREYQTLAFPPIKKEGAFGDLVEVCEVGLRPRGHPQRVTARVLLPRDYDYFVSAGEKFSAPALVALFRQWHTTVHAAPGALAPVFAFLGPEFEVRGGPVPYFAVLGFPGWPTFTVPATAESARDLVRGAAAAYAALLGAWPAVGARVVLPPRAWPGVASAAAGCLLPAVREAVARWHPATKIIQLLDPPAAVGPVWTARFCFPGLRAQLLAALADLGGSGLADPHGRTGLARLDALVVAAPSEPWAGAVLERLVPDTCNACPALRQLLGGVMAAVCLQIEETASSVKFAVCGGDGGAFWGVFNVDPQDADAASGVIEDARRAIETAVGAVLRANAVRLRHPLCLALEGVYTHAVAWSQAGVWFWNSRDNTDHLGGFPLRGPAYTTAAGVVRDTLRRVLGLTTACVPEEDALTARGLMEDACDRLILDAFNKRLDAEYWSVRVSPFEASDPLPPTAFRGGALLDAEHYWRRVVRVCPGGGESVGVPVDLYPRPLVLPPVDCAHHLREILREIELVFTGVLAGVWGEGGKFVYPFDDKMSFLFA
The following text describes a protein:
Function:
Possible regulatory or functional link with the histocompatibility cluster.
Sequence:
MSERGRGGGAGGGAARGGGRAKAGVGGAAGAGGGEGAPGWKKAAGANLSAKAKKEYLKWKREQKRNQADDDSDGDWGVDEENGPAATVAAAVAAGHAAVAAAEAAEEDAAGVPVAGGARRRGPDGGDKGRAGGGAGAGGGRGGGRPKRDGAAAGTGDATATATGEGLPRPVPPGKDARHLQAAAHPHPHPHPHPHPHPGRHSNKQEALLGDFAVPTDGGDDDEAAEDDVAPEVRERAEALAAAVAASHVHSPGRVTRHDAYLGNAQHGKDHGHAHGHAGTHAGHEGPRGHDEHQLAAAAAAAVVGGRPPARSGTWNTPTTQAVVAAQAAAAHGAGGRGAGGGAAGGGGGGGRAAPDSLPLRYVPMVDLPPGDVPANIREACPEVEAMRLPRVREEEVGFGEEGRRLGMPKRPAWRGVVRSADQLHALEESSFLSWAEQLYKGVDRPSRVSFFEPKLDFWRQLWRVLERSDVAVMIVDARNPLLHFSEALAQHVMCDHGMAALLVLNKADLVPVAAAEAWRGWFECRYPGLKVVVSSAAGAQGGAASGGAAGAILDAVLECDISRDGRRVKVSEVVGMSRDQILAASKARNTHSKRDRPPPATQQPQSQSRHEKAEAQEAGGGGSWEKDGDADEDEDVEEEEEEEEEAWDTKGTKQKKKAALKKKRTARMHAGAAATAGGVAGGGKQQGGAPAKGAAGGGKGRGSARRGAAPDAEDGDESEAAVEAEAAASGPSRAETEGEEGEGESAEEGEGEEEEEEAAGAEDSDNDNAAFDALAADEDEEDFKQQGDEEEDEEDKEKGREQAARSGGSAAAAATSGGWGGHGARGGHDRRGRSRPVVVCVVGEPNVGKSSTMNALLGAKRVAVSSHPGRTKHYQTHVMCPSLMLCDCPGLVFPRLDVSLPMQVLFGSYPIARCRDPYAVVRYLAERVWPRLHHTLALKPVAEEDAEEERGGAGGGGGAGGGGAGGGGAGGGGAGGGGAGGGGAGGGGAGGGGAGGGAGGDLQARARRRHDTAPQWSDDDWTPAALVESLAAKHNWRSRRGGRLDVYRAANWVLRAALAGRYGVDVAFLPPAAAE
The following text describes a protein:
Function:
Part of a multidrug efflux pump. Confers resistance to cationic lipophilic dyes such as ethidium bromide, acriflavine, pyronine Y and safranin O. The efflux is probably coupled to an influx of protons (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAFTFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLNQSKAHAEDKKQTACE
The following text describes a protein:
Function:
Important role in the capacity of milk to transport calcium phosphate; Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors.
Miscellaneous:
MISCELLANEOUS: In milk, the alpha s1- and beta-caseins precipitate in presence of calcium (so-called calcium-sensitive caseins). Kappa-casein prevents the precipitation of the other caseins by calcium through the formation of large stable colloidal particles termed micelles.
Subcellular Localization:
Secreted.
Sequence:
MRLLILTCLVAVALARPKLPLRYPERLQNPSESSEPIPLESREEYMNGMNRQRNILREKQTDEIKDTRNESTQNCVVAEPEKMESSISSSSEEMSLSKCAEQFCRLNEYNQLQLQAAHAQEQIRRMNENSHVQVPFQQLNQLAAYPYAVWYYPQIMQYVPFPPFSDISNPTAHENYEKNNVMLQW
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Membrane; Single-pass membrane protein. Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLTVLGRLLERNSIYVATIFGGAFAFQGFFDVAVNKWWEEHNKAKLWKNVKGKFLEGEGEEEDDE
The following text describes a protein:
Function:
Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA; Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MSKTRRWVIILLSLAILVLIGINLADKDDPAAVMVNSNDPTYKSEHTDTVVYSPEGALSYRLIAQHVEYFSDQAVSWFTQPVLTTFDKDKVPTWSIKADKAKLTNDRMLYLYGHVEVNALVPDAQLRRITTDNAQINLVTQDVTSNDLVTLYGTTFNSSGLKMRGNLRSKNAELIEKVRTSYEIQNKQTQP
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Miscellaneous:
MISCELLANEOUS: Present with 4684 (+/-522) molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTSKTSESGTGTQSTIVQLRNLPDLTEISHLEIDAPVVEILKKTVLFQLNSLNICISNFALDELVNLVTVQMDGMFRNLHNLTLLQRRSQASQADLKLLLREFNLDAPSLYQQFQASEFIKSKHSTEYEKLMSWSSLAALPHNEEDEEDELNNIEEQQNEINVLLPPSNPLEKQIPSWLPNFPPDHTYKFTPEFNHPITDLKTIKKEIVKESQESEKALLNLNKSLSHISSASNTPQPPGLDDEDAIEQQLEIWGNALEERKPTITEKSFNENNIEQYAKYRVELARERVTKFEVNQLKRTKNPFLKISETLYLPESPHQSHKTIQKTIELQFRKSMTLFMHNLPKVQKLKKEKIRMAKEERAKSLKRRQEELISQRTKREQDEGHDLELLLNNEHARDAADDTTTPNALNNSTIVINTNAEDEDDDINLFGILGSSEDENEMSSMPAENLVAESEPPTMTAQDTTNTTPVAHNTTNIDATTSHSPHSTPNENAPTSPPADIATDHDITM