lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds covalently through a thioester bond to the pathogen surface resulting in pathogen clearance; Modulates negatively TGFB1 signaling in keratinocytes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MFRIFLTGIILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNETKQIELPPMSTQNVEFEVPKLATGNYNLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKATYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLGTWKISVSVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATVSMERSYGYFGDLNANGNKQEKTIDVDGKGHVEFDIIHWAQRGQYLPPIKLFAVVTEELTGNKQNATATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLPDSDSRYYRIFASFDGSENTIGSISKFEPTPMSREPLKIQVNTKKPRLGEQVSFDVVSIEDLPYFVYTIVARGNVILSDYVDVPDGQKTYTVKFTPTFSMVPKATIYVYYVVNNDLQFEEKTIDFEKEFSNSIDVSAPTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTSTPWMNGYGRYPGQTSGLVTLTNANYPYNTGPLVMSYVFEGSRHPWITRPRYRVGIRGDSGDRISFLSQSLNDRNLKEILLKQTPQRTTIRKEFPETWFFENVGEEEFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITATSALAGDAIHQKLKVEPEGVTLFENRAVFINLKDQPEMSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKLFDNANQNPLALTSFVLLAFFENHELIPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLAKHPQSEKVIAKLESVARKENDRMWWSKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEKALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGSGSGTMDIEFSSAGESKNTIKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNLAEKEKKPSFKVTPTVKDTPNQLLIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGKIQAVDRVKRVETKNSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVKSSLCDICEGADCGEGCKKD
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MNMLGSMFSTVKPRLDDLGTDRLNYYYSTLIIMGMSLTITARQYVGSPLQCWVPAQFTKAWEQYAEDYCFVYNTYWVKPNDKVPTTIEERVSQQLIYYQWAPFIMAIEAAFFYLPVIFWSMLSTKSGINIIKLVETAQKAEGAESEDRKKQIDIICRHISNNLRKRRNEEETTKMAKIQRIFGMQHGKFITNVYLVTKFIYMLNSFLQFYSTNKFLGQNDPYWGMRILDDILHGTDWEHSGNFPRIAMCDFQVRVLGNLQRHSIQCVLTLNMFNEKIFLFLYIWFLLVFFVTLFDSIFLIYNMFSSHKIVEFLQQFLDNQEADENEEKKPDDEKKKVYRKEQHAILLSEFCLHKFTPDIIILLKMINNHTGDIVCTEIVGRMWNDFLKRDAKLVLQKFVDNDPNMETKSSSLKSVQLFEEHKGLI
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSGVAGGASKKSSSRTMATKKLIIDEFKRRLRDNIKSLNDNFFHIIQAAKVNPDDNAYKNQTGKMTEFYTTKNEMAVRAQLMVRASDELLKLTADLKEFLILHDFHFLTHNIKQAEAQCEETLRQQSHQHNCLDSEVSNILFDLEREIAENFYLRHT
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MRLSSILNGQHFGNLAKVHGIVTYKLSPFEQRAFAGAISKGLPNMVRRFRSNVFIVTPPFIVGYLIYDLTERKHTALLRKNPADYANDE
The following text describes a protein:
Function:
Has antibacterial activity against E.coli ATCC 25992 (MIC=15 uM), E.coli CIB 84492 (MIC=15 uM), S.aureus ATCC 25923 (MIC=8 uM) and S.aureus CIB 85462 (MIC=8 uM). Has antifungal activity against C.albicans (MIC=31 uM). Has hemolytic activity against rabbit erythrocytes.
Subcellular Localization:
Secreted.
Sequence:
GIFGKILGVGKKVLCGLSGMC
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It prefers amino acid residues with hydrophobic side chains like leucine and phenylalanine in the P1 position of the peptides substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MPVAMARHILVKTEAEAAQLKQRLAKGEDFATLAKKHSTCPSGKRGGDLGEVRPGQMVRSIDNAIFRKPVGVLQGPLKSQFGYHLLEVYFRD
The following text describes a protein:
Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MSSTGNKRAPTTATQRLKQDYLRIKKDPVPYICAEPLPSNILEWFKRFSCLSLLSSWDYRHYVVRGPEMTPYEGGYYHGKLIFPREFPFKPPSIYMITPNGRFKCNTRLCLSITDFHPDTWNPAWSVSTILTGLLSFMVEKGPTLGSIETSDFTKRQLAVQSLAFNLKDKVFCELFPEVVEEIKQKQKAQDELSSRPQTLPLPDVVPDGETHLVQNGIQLLNGHAPGAVPNLAGLQQANRHHGLLGGALANLFVIVGFAAFAYTVKYVLRSIAQE
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis.
Sequence:
MSSTAGGEVSINSGDLLLGTLSTSITKLEQQIRATQLSQKKLNSDCETMAEYLRDLSEYKQPVDLLPYVGKLNDSTIRVNNTHQKLDDLLERLTKLQRQIARETYKKKNSIKEQEPPVQPEN
The following text describes a protein:
Function:
Component of the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, that catalyzes the overall conversion of branched-chain alpha-ketoacids to acyl-CoA and CO(2).
Sequence:
MTQIADRPARPDETLAVAVSDITQSLTMVQAINRALYDAMAADERVLVFGEDVAVEGGVFRVTEGLADTFGADRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTAGLKVVVPSTPGDAYWLLRHAIACPDPVMYLEPKRRYHGRGMVDTSRPEPPIGHAMVRRSGTDVTVVTYGNLVSTALSSADTAEQQHDWSLEVIDLRSLAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQEEMFYQLEAPVLRACGFDTPYPPARLEKLWLPGPDRLLDCVERVLRQP
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5. Required for the normal expression of the Integrator complex component IntS1.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger is not required for 3'-end snRNA processing.
Sequence:
MAANIAAAAAAAQEVDPVLKKAIKLLHSSNPTSAAELRLLLDEALKARFGPEKSLTNNMTPRMLEDEANFSGRAATPPQQPINADEIINLTNSPDKEPSDSVDTIADSDDGLSAVGIVNTGDTGDFGDLNCCVCGEMVFTATNRLIECSKCGAMYHQECHKPPITKEEAADDQEQNWQCDTCCNKPTSSGRTTSSAAAVTPTVFIADEPMPLTSKAKSSVASSRSSNSSNSSSPFYRPEPSSSTNASSSSSSKHGHKSSSSSSSKSHKEERSSKSTAASSLSAIGGMEKHNSSGTSSRRSGSSTKSSSKSSSSKHHESGSSSKRRSKQ
The following text describes a protein:
Function:
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming. Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. It thereby plays an essential protective role for RBC survival in anemias of iron deficiency. Iron deficiency also triggers activation by full-length DELE1 (By similarity). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (By similarity). Also acts as an activator of mitophagy in response to mitochondrial damage: catalyzes phosphorylation of eIF-2-alpha (EIF2S1) following activation by S-DELE1, thereby promoting mitochondrial localization of EIF2S1, triggering PRKN-independent mitophagy (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MLGGSSVDGERDTDDDAAGAVAAPPAIDFPAEVSDPKYDESDVPAELQVLKEPLQQPTFPFLVANQLLLVSLLEHLSHVHEPNPLHSKQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHHNRAITHLMRSAKERVRQDPCQDNSYMQKIRSREIAFEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSATKTDCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVVQPQDRVPIQLPSLEVLSEQEGDRDQGGVKDNESSSSIVFAELTPEKEKPFGESEVKNENNNLVSYTANLVVRNSSESESSIELQEDGLTDLSVRPVVRHQLPLGHSSELEGNFTSTDESSEGNLNLLGQTEVRYHLMLHIQMQLCELSLWDWITERNKRSREYVDEAACPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACADIIQNADWTNRNGKGTRTHTSRVGTCLYASPEQLEGSQYDAKSDMYSLGVILLELFQPFGTEMERATVLTGVRTGRIPESLSKRCPVQAKYIQLLTGRNVSQRPSALQLLQSELFQTTGNVNLTLQMKIIEQEKEIEELKKQLSLLSQDRGLKR
The following text describes a protein:
Function:
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.
Subcellular Localization:
Lysosome.
Sequence:
MIWKVATFLSVALGIDAITVGVDSPENGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIANAKDNPTPGIVINRPNGTDVYQGVPKDYTGENVTSENFLAVLRGDAEAVKGKGSGRVLKSGPRDHVFVYFTDHGATGLLVFPNDDLHVRDLNKTIQYMHKHKKYGKMVFYIEACESGSMMDHLPDDINVYATTAANPTESSYACYYDEERGTYLGDWYSVNWMEDSDVEDLTKETLHRQYQLVKSHTNTSHVMQYGNKSIASMKLMQFQGMRHRASPPVSLPPVPHLDLTPGPDVPLEILKRKLKSRANSSQYRKLSAEMHRLQNARTILEKSVSKVVLLLADSQAEAARLLSTRSPLTKHDCYEAAVTHFRTHCFNWHSSTYEYALRYLYVLVNLCEKPYPLDRIKLSLDKVCLGYY
The following text describes a protein:
Function:
As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses (By similarity).
Subcellular Localization:
Cytoplasm. Synapse. Cell projection, dendritic spine. Note=Colocalizes with DLG4 in asymmetric synapses.
Sequence:
MVCEKCEKKLGRVITPDTWKDGARNTTESGGRKLNENKALTSKKARFDPYGKNKFSTCRICKSSVHQPGSHYCQGCAYKKGICAMCGKKVLDTKNYKQTSV
The following text describes a protein:
Function:
Required for repair of DNA double strand breaks which occur during replication or are induced by ionizing radiation (IR). Functions with dgrn and downstream of the SMC5-SMC6 complex to regulate strand break repair. Likely functions by stabilizing the association of heterochromatic double strand breaks (DSBs) with the nuclear periphery as part of the homologous recombination (HR) repair process.
Subcellular Localization:
Nucleus. Nucleus, nucleoplasm. Note=Associates with the nuclear pores and localizes to the nuclear periphery.
Sequence:
MSDDDCDIFSAARKRIPEIALPKNPYNLGNDSFSKEVDYDFIEDLPKKSTKTGKRKNPAATRKNPPKSQDDASPPKQAEHKAVEPEEDMRTERSLSPVSLLILEMEKKNGQQSDVEKHAKENDVGPVARRTRSSLNRSEMAPPPVSPTVEVPTQTKPKKRGQKKRTSLTTTTSNSASMEVSLPSIVGQNNEHISRRWTLAEVAARSKVVDSIDLVSAVAPRVEGFVNLDSEDEGEKEAPPVVEEENIFDNDNPTIEVALSWLGEIQIYKLRQHQKFKHLFKELASRNGIDENDITVDMYYNFVGPEDTPHSIGLKSFHTLTGHPTKSHNNNNVAAKIDYNPEALCRKPKKFQVKVQADKWKHPLVIPMKKTDNFKIIFIKCAEELNCDPRTIKLFFDGDLLDPNDTPNNQDMEGNEVIDLKIKA
The following text describes a protein:
Function:
Involved in double-strand break repair and/or homologous recombination by mediating RAD51- and DMC1-facilitated DNA repair. Plays an essential role in both somatic and meiotic homologous recombination. Is crucial for the formation of RAD51 and DMC1 foci during male meiotic homologous recombination in prophase I.
Sequence:
MPGRWRVWGQPDGSLVWIPAPELGAPLPPAAAPPPPPPLPPGRGAGIADASSEDALSKGRGAADGCRVESMADLLVQARNTLLEGDRMSGATVDAGEGQLFCTGSGRSVSVSERAIRRARALVGEDVEKAGTKRKQPFDDVPGAEGELRETDALFRGGVHNTTMPPVFQTGSGKTVLLGKDSIQKARAILGEQPFDDVPDAEGESSEMDAPFRGGAYNATRPPVFQTGSGKAVLLGKDSIQKARVLLEDVDRAAGVVEPMFRTGMGRPVPVSRTSIDKARAALEGQTVAEKGVDGMEQFPLFQTGSGRVVSVSAASVQKAKSVLKDNSTSEENTESFGRSNQAMMFPTGSGRPAMISERSIERSRVVGNKGDAKKSGHWDADCQFPMFQTGLGKPVAVSWSSVQKARAVLEEEKIKTTGRGDSSDCATTLQTETPTSVMSSSLIMNDRSVTPKEDSAMQVTRIEKNHKDDDHVPLFQTGLGRSIAISKSSLKRASAVLEPRNIAKELEDEVHLDGAHDTPVSRTGLGRSILASENSRKELPILEAEEAVRSVNNYNGETFVEEATFQAGIQKFVPQNRSSSHKASMLLEQRNFMEKGYEDCGSQLPMFRTGSGKSVLISENSVQKARAVLEEQGKISRDNPKLLNMDKKIPVFASPLKTSCARTVNISSVGVSRAATLLGLEENTLSTQFFGHVGDKLGRKINFERENPEQRPGLAPYPTENQVHKEPHRPFELSNKTASDSGEHSIRFSTAGGRSMAISSDALQRAKNLLGESDLVVSTNNLVGYSLASACNDKMENSTAAPKEGGPDLSKRRRASGRTELATFSHQAMSDRKHTGSFGNAAPTNESTNMFHVGSRSISEIPKITELSSRCLSEIDNANDTKDKTQELHMPAGALVDISNFMGAHSGKIDHAVNEKRRIGGRNSASSFKRPRSSRFITPISINKQSSAGVPKLPPTQITSCRTKLSSSYPFKHKRKTWKEYFGGPPCFNCLTEHITDEVKLMDAKGAEKYKFHDTNTGAEEFQKMLLACGASLTYATKEWVNNHYKWIVWKLASLERCYPTKAVGKFLTVPNVLDELKYRYDREVNNGHRSAIKKILEGNALPSLMMVLCISAIYSHPDVNKLEAGGPDGNENSIDNKSLLAAKRNMSAHIELTDGWYALEASLDVALSEQLQKRKLSMGQKLRIWGASLCGWTGPVSFHEASGTVKLTIHVNGSYRARWDDPLGFCKHIGPPLAFKCIKASGGRVPRTLVGVARIYPVLYRERLPEGRSVVRSERMERKALQLYQQRVSKIAEDIMSEQDENCANTDDSEEGAKICKMLEQAAEPEVMMAGMTSEQILSFSSYQAKQKEARQNEVAKKVENALEVAGLSSRDVTPFLKVRVTSLVHRISATKTINKEGLITIWNPTEKQKADLVEGQVYIATGLLPSAHCTNILYLHARGSSTTWNSLTSAQAADFEPFFTPRKAVELSWIGEVPLTSEFDIAGVVLHVGDVYSCSSQKRQWLFLTDGSKFISASQSTEQDDYLLAVSFSCSTVGDDSAFFSYALSGNTVGFSNLVKRHKDQTRRIWVAEATASSTYTLSHEISKKSHLKEAATRAEKWASSSFDKIQQLKERVLCIIGDSGG
The following text describes a protein:
Function:
Important for the colocalization of sister nascent DNA strands after replication fork passage during DNA replication, and for positioning and subsequent partitioning of sister chromosomes. Does not have GTPase activity on its own.
Subcellular Localization:
Cytoplasm. Note=About half the protein co-localizes with beta sliding clamp (DnaN) at midcell, the rest without clamp in quarter-cell positions when chromosomes are condensed during DNA replication.
Sequence:
MYTQTLYELSQEAERLLQLSRQQLQLLEKMPLSVPGDDAPQLALPWSQPNIAERHAMLNNELRKISRLEMVLAIVGTMKAGKSTTINAIVGTEVLPNRNRPMTALPTLIRHTPGQKEPVLHFSHVAPIDCLIQQLQQRLRDCDIKHLTDVLEIDKDMRALMQRIENGVAFEKYYLGAQPIFHCLKSLNDLVRLAKALDVDFPFSAYAAIEHIPVIEVEFVHLAGLESYPGQLTLLDTPGPNEAGQPHLQKMLNQQLARASAVLAVLDYTQLKSISDEEVREAILAVGQSVPLYVLVNKFDQQDRNSDDADQVRALISGTLMKGCITPQQIFPVSSMWGYLANRARYELANNGKLPPPEQQRWVEDFAHAALGRRWRHADLADLEHIRHAADQLWEDSLFAQPIQALLHAAYANASLYALRSAAHKLLNYAQQAREYLDFRAHGLNVACEQLRQNIHQIEESLQLLQLNQAQVSGEIKHEIELALTSANHFLRQQQDALKVQLAALFQDDSEPLSEIRTRCETLLQTAQNTISRDFTLRFAELESTLCRVLTDVIRPIEQQVKMELSESGFRPGFHFPVFHGVVPHFNTRQLFSEVISRQEATDEQSTRLGVVRETFSRWLNQPDWGRGNEKSPTETVDYSVLQRALSAEVDLYCQQMAKVLAEQVDESVTAGMNTFFAEFASCLTELQTRLRESLALRQQNESVVRLMQQQLQQTVMTHGWIYTDAQLLRDDIQTLFTAERY
The following text describes a protein:
Function:
Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci (By similarity).
Subcellular Localization:
Nucleus. Note=Colocalizes with CREB3 in nuclear foci.
Sequence:
MPQPSVSGMDPPFGDAFRSHTFSEQTLMSTDLLANSSDPDFMYELDREMNYQQNPRDNFLSLEDCKDIENLETFTDVLDNEDALTSNWEQWDTYCEDLTKYTKLTSCDIWGTKEVDYLGLDDFSSPYQDEEVISKTPTLAQLNSEDSQSVSDSLYYPDSLFSVKQNPLPPSSFPSKKITNRAAAPVCSSKTLQAEVPSSDCVQKASKPTSSTQIMVKTNMYHNEKVNFHVECKDYVKKAKVKINPVQQGRPLLSQVHIDAAKENTCYCGAVAKRQERRGVEPHQGRGTPALPFKETQELLLSPLTQDSPGLVATAESGSLSASTSVSDSSQKKEEHNYSLFVSDNMREQPTKYSPEDDEDDEDEFDDEDHDEGFGSEHELSENEEEEEEEEDYEDDRDDDISDTFSEPGYENDSVEDLKEMTSISSRKRGKRRYFWEYSEQLTPSQQERILRPSEWNRDTLPSNMYQKNGLHHGKYAVKKSRRTDVEDLTPNPKKLLQIGNELRKLNKVISDLTPVSELPLTARPRSRKEKNKLASRACRLKKKAQYEANKVKLWGLNTEYDNLLFVINSIKQDIVNRVQNPREEREPSMGQKLEILIKDTLGLPVAGQTSEFVNQVLGKTAEGNPTGGLVGLRIPASKV
The following text describes a protein:
Function:
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or grb2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Sequence:
MNIRRCGHSENFFFIEVGRSAVTGAGEFWMQVDDSVVAQNMHETILEAMKALSDEFRPRSKSQSSSNCSNPISVPLRRHHLNHPPPSQVGLNRRARTESATATSPAGGAAKHGSSSFRVRASSDGEGTMSRPASMEGSPVSPSASRTQSHRHRGSSRLHPPLNHSRSIPMPATRCSPSATSPVSLSSSSTSGHGSTSDCMCPRRSSASISGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSMGHTPPAREEELNNYICMGKSSSHLQRGPQQRYQPSRGEELTDFDKVFRKRTHSSGTSPPTVSHQKTPSQSSIEEYTEMMPTHPVRLTSFRHSAFVPTYSYPEECLDLHLEGSRANHKDDGYMPMSPGVAPVSTKTNDYMPMSPKSVSAPQQIINPRWHSAVDSNGYMMMSPSGSCSPDNTNYSKIWTNGTNPKLSIDSIEGKLPCSDYINMSPASGSTTSTPPDSYLNSVEESTKPVYSYFSLPRSFKHVHRKSEDGNLRISANSGHNLYTEDSSSSSTSSDSLGGQDPQQPRKGEGCIQGKRLTRPTRLSLENSSKASTLPRVREPALPPEPKSPGEYVNIEFNDKVFSGGLVPSMCSLPFVQSRVVPQRENLSEYMNMDLGVWRAKTSYASTSSYEPPNKPVNSVCPTETCSSSRPPIRGKPISRDYMSMQLGSLCPDYSQVPPTRLSAKSITLSSSKSNYAEMSSGRVSDNIPAIAPASNSSLSEASRSSLLGQGSGPSAFTRVSLSPNRNPSAKVIRAGDPQGRRRHSSETFSSTPTTARVTTGPVSGEDVKRHSSASFENVWLRPGEIARRDSLQPSDHTHNGLNYIDLDLAKDLSSLDHCNSHQSGVSHPSDDLSPYASITFHKLEEHRSQAETEE
The following text describes a protein:
Function:
Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes; In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasm.
Sequence:
MTNSNYKSNNKTYNENNNEQITTIFNRTNMNPIKKCHMREKINKYFFLIKILTCTILIWAVQYANNSDINKSWKKNTYVDKKLNKLFNRSLGESQVNGELASEEVKEKILDLLEEGNTLTESVDDNKNLEEAEDIKENILLSNIEEPKENIIDNLLNNIGQNSEKQESVSENVQVSDELFNELLNSVDVNGEVKENILEESQVNDDIFNSLVKSVQQEQQHNVEEKVEESVEENDEESVEENVEENVEENDDESVASSVEESIASSVDESIDSSIEENVAPTVEEIVAPTVEEIVAPSVVESVAPSVEESVEENVEESVAENVEESVAENVEESVAENVEESVAENVEESVAENVEESVAENVEEIVAPTVEESVAPTVEEIVAPSVEESVAPSVEEIVVPTVEESVAENVEEIVAPSVEEIVAPSVEEIVAPTVEESVAPTVEEIVAPSVEESVAPSVEEIVVPTVEESVAENVEESVAENVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPTVEEIVAPTVEEIVAPSVEEIVAPTVEESVAENVATNLSDNLLSNLLGGIETEEIKDSILNEIEEVKENVVTTILENVEETTAESVTTFSNILEEIQENTITNDTIEEKLEELHENVLSAALENTQSEEEKKEVIDVIEEVKEEVATTLIETVEQAEEESASTITEIFENLEENAVESNENVAENLEKLNETVFNTVLDKVEETVEISGESLENNEMDKAFFSEIFDNVKGIQENLLTGMFRSIETSIVIQSEEKVDLNENVVSSILDNIENMKEGLLNKLENISSTEGVQETVTEHVEQNVYVDVDVPAMKDQFLGILNEAGGLKEMFFNLEDVFKSESDVITVEEIKDEPVQKEVEKETVSIIEEMEENIVDVLEEEKEDLTDKMIDAVEESIEISSDSKEETESIKDKEKDVSLVVEEVQDNDMDESVEKVLELKNMEEELMKDAVEINDITSKLIEETQELNEVEADLIKDMEKLKELEKALSEDSKEIIDAKDDTLEKVIEEEHDITTTLDEVVELKDVEEDKIEKVSDLKDLEEDILKEVKEIKELESEILEDYKELKTIETDILEEKKEIEKDHFEKFEEEAEEIKDLEADILKEVSSLEVEEEKKLEEVHELKEEVEHIISGDAHIKGLEEDDLEEVDDLKGSILDMLKGDMELGDMDKESLEDVTAKLGERVESLKDVLSSALGMDEEQMKTRKKAQRPKLEEVLLKEEVKEEPKKKITKKKVRFDIKDKEPKDEIVEVEMKDEDIDEDIEEDVEEDIEEDKVEDIDEDIDEDIDEDIGEDKDEVIDLIVQKEKRIEKVKEKKKKLEKKVEEGVSGLKKHVDEVMKYVQKIDKEVDKEVSKALESKNDVTNVLKQNQDFFSKVKNFVKKYKVFAAPFISAVAAFASYVVGFFTFSLFSSCVTIASSTYLLSKVDKTINKNKERPFYSFVFDIFKNLKHYLQQMKEKFSKEKNNNVIEVTNKAEKKGNVQVTNKTEKTTKVDKNNKVPKKSRTQKSK
The following text describes a protein:
Function:
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
Subcellular Localization:
Cytoplasm.
Domain:
Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
Sequence:
MYEYIKGKYIDMYKDYIVIENNNIGYKIYTSGSTMAKLPSIGENIMLYTEQIVREDFIGVYGFLTKDELSMFKLLLTINGVGAKAALSLLSISNVSTLKYAIKMGDEKTITRAPGIGKKTAQRIILELKDKIEIDILEEDDEQIINKVADDKKVLEAVAALVTLGYSEKEANKVINSCDKNNSLEQIIKEALKYLMK
The following text describes a protein:
Function:
Counteracts the antiviral effects of host IFN-alpha/beta and key IFN-inducible proteins involved in viral RNA degradation suxh as host OAS1. Acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.
Subcellular Localization:
Secreted. Note=Found associated with both uninfected and infected host cell membranes after secretion.
Sequence:
MTMKMMVHIYFVSLLLLLFHSYAIDIENEITEFFNKMRDTLPAKDSKWLNPACMFGGTMNDIAALGEPFSAKCPPIEDSLLSHRYKDYVVKWERLEKNRRRQVSNKRVKHGDLWIANYTSKFSNRRYLCTVTTKNGDCVQGIVRSHIRKPPSCIPKTYELGTHDKYGIDLYCGILYAKHYNNITWYKDNKEINIDDIKYSQTGKELIIHNPELEDSGRYDCYVHYDDVRIKNDIVVSRCKILTVIPSQDHRFKLILDPKINVTIGEPANITCTAVSTSLLIDDVLIEWENPSGWLIGFDFDVYSVLTSRGGITEATLYFENVTEEYIGNTYKCRGHNYYFEKTLTTTVVLE
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively. Redundant to LCB4, is only responsible for few percent of the total activity. Involved in the biosynthesis of sphingolipids and ceramides. Involved in heat-induced transient cell cycle arrest. Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance.
Miscellaneous:
MISCELLANEOUS: Present with 1760 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MTLKPSKRRKGRSRHSRKKQITSAILTEEGIMIKAKPSSPYTYANRMADKRSRSSIDNISRTSFQSNISRTSFQSNSDNNSIFETASLISCVTCLSDTDTIDRSETSTTDTSKDDLSANPKLHYPSVNGQLPANTVIPYGRILDARYIEKEPLHYYDANSSPSSPLSSSMSNISEKCDLDELESSQKKERKGNSLSRGSNSSSSLLTSRSPFTKLVEVIFARPRRHDVVPKRVSLYIDYKPHSSSHLKEEDDLVEEILKRSYKNTRRNKSIFVIINPFGGKGKAKKLFMTKAKPLLLASRCSIEVVYTKYPGHAIEIAREMDIDKYDTIACASGDGIPHEVINGLYQRPDHVKAFNNIAITEIPCGSGNAMSVSCHWTNNPSYSTLCLIKSIETRIDLMCCSQPSYAREHPKLSFLSQTYGLIAETDINTEFIRWMGPARFELGVAFNIIQKKKYPCEIYVKYAAKSKNELKNHYLEHKNKGSLEFQHITMNKDNEDCDNYNYENEYETENEDEDEDADADDEDSHLISRDLADSSADQIKEEDFKIKYPLDEGIPSDWERLDPNISNNLGIFYTGKMPYVAADTKFFPAALPSDGTMDMVITDARTSLTRMAPILLGLDKGSHVLQPEVLHSKILAYKIIPKLGNGLFSVDGEKFPLEPLQVEIMPRLCKTLLRNGRYVDTDFDSM
The following text describes a protein:
Function:
ArgR could be a transcriptional activator of the dauBAR operon in response to the presence of L-Arg.
Sequence:
MTAQPQRIGFLLWPATRALTLSLAEEALRAARRLHPEALYEPLFLLAEAPAEEEGWRLPGTAWNGRLEQCSRLFLVADEAPAAVSPALGLALKQLARSGAAIGALSAGIYPLAQLGLLDGYRAAVHWRWHDDFTERFPKVIATNHLFEWDRDRMTACGGMAVLDLLLALLSRDHGAELAGAVSEELVVERIREGNERQRIPLKNRLGSSHPKLTQAVLLMEANIEEPLTTDEIAQHVCVSRRQLERIFKQYLNRVPSQYYLELRLNRARQMLMQTSKSIIQIGLSCGFSSGPHFSSAYRNFFGVTPREDRNQRRGGSAFETTFTPVERG