lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes two different reactions involved in the biotin biosynthesis; Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring; Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site; MISCELLANEOUS: [Isoform 3]: May be due to a competing acceptor splice site; MISCELLANEOUS: [Isoform 4]: May be due to an intron retention.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MIPVTATLIRHRLRHLRHRIRFKSTSVSPFHLPLNHPTYLIWSANTSLGKTLVSTGIAASFLLQQPSSSATKLLYLKPIQTGFPSDSDSRFVFSKLDSLSLRRQIPISISNSVLHSSLPAAKSLGLNVEVSESGMCSLNFRDEKTVTGAPELLCKTLYAWEAAISPHLAAERENATVEDSVVLQMIEKCLKEEMECGVKSEKSDLLCLVETAGGVASPGPSGTLQCDLYRPFRLPGILVGDGRLGGISGTIAAYESLKLRGYDIAAVVFEDHGLVNEVPLTSYLRNKVPVLVLPPVPKDPSDDLIEWFVESDGVFKALKETMVLANLERLERLNGMAKLAGEVFWWPFTQHKLVHQETVTVIDSRCGENFSIYKASDNSSLSQQFDACASWWTQGPDPTFQAELAREMGYTAARFGHVMFPENVYEPALKCAELLLDGVGKGWASRVYFSDNGSTAIEIALKMAFRKFCVDHNFCEATEEEKHIVVKVIALRGSYHGDTLGAMEAQAPSPYTGFLQQPWYTGRGLFLDPPTVFLSNGSWNISLPESFSEIAPEYGTFTSRDEIFDKSRDASTLARIYSAYLSKHLQEHSGVRQSAHVGALIIEPVIHGAGGMHMVDPLFQRVLVNECRNRKIPVIFDEVFTGFWRLGVETTTELLGCKPDIACFAKLLTGGMVPLAVTLATDAVFDSFSGDSKLKALLHGHSYSAHAMGCATAAKAIQWFKDPETNHNITSQGKTLRELWDEELVQQISSHSAVQRVVVIGTLFALELKADASNSGYASLYAKSLLIMLREDGIFTRPLGNVIYLMCGPCTSPEICRRLLTKLYKRLGEFNRT
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MNPIRPIRVQEAYRFSQLGVSQTNFKFGQIFFESDKYITIRETAPNGDTQLLQFNFETKQLISRKPNKADSALMHPEKNIIALRAAGEQPNSTVIQIFNLDEKQRIKNVELNETIVFWRWVNPQKLAYVTPTAVYHINITNPNEQQVKVMDRYPLSLENPVQIIGYGLEGNEKWCALYGISTPDGGRTINGHIQLFLIEQARQQILEGHCCCFGDALIHTDDYKSSLFCFVERKSGETTSRLHITEIGVPPNGFQKYKRQVEVQTDPNYPTDFPVLMHINQKYGLIYVISKFSFLTVYELSTASLIFRERICNENVFVGAPNINQGQYHIIGKEGIVYTISVNDDQLVSYLINTCRHIPDVIQLGFRLASRYKLPGADNMFVDQFNKAILSGDALSAAKIAASAPGTVLRNPERQPQPLIVYFQTLLEKGTLNKFEAIELCGPILQQGRKQFVEQWIAQNKLEPSDELGDLLKRYDANLAIQIYKQSKSYQKLAQCYMETGQLELAMQLQQQFGVSTDYMAMLRNMMMQSPEQALAMAKSLYQRDQSINVHQIAELFEQFQRLPEMTAFLVECMKNNRAEDGPLQTKVLCLNLQAAAQVADAILQMNIWTQFDRIRVAQLCEQKGLYQRALENYSDPKDVKRVILNTHALPPEFLVNFLSRVDPALTLQCLQDLLRHNRQNLQVVVNLALKSFESVSAFEGVYLFLGSLINTTSDKDIYYKYIEAAAKCNQIKELERVITEKGDCYDADKVKNYLKEQKLSDPRPLIFLCDMNGFVDELTRYLYKNGFTRYIEIYIFKVNPNAAPGVFGTLIDLECDEVYLKQLLYNIRGMCPIEPTVDEFEKRNKLRVLEQWLEARVTEGNQIPAIHNALAKIKIDTSQDPDGFLINNQFYDAKAVGKFCEERDPQLAVLAYKRAWGQCDQELINLTNKNEMYRVQAKYLVERQDVDLWAGVLQETNPHRKNLIDYVIQALQDSKNVDEVQAAVKAFVLAKIPYELLGLLEKLVLHNPEFMQYKQLQNLLIITAIQSDTSKVLDYINRLDKFDPQIIAQHCLNEEYNLFEEAYAVFKKFNLHIDAVNVLLRNLGSIPRAHEYAQYASSPEVWSLLAEAYLNQGQTNESIDCYIKANDSSAFLNIINVAEQEEKYELLVKYLLMCRQTVKDVNIDNSLIYCYAKLDKNLDVESLIQSSNSADVIKVGERCYDQQLYEAAKILFTALKNNARIASCLVRLKQFNKAIEAAQKANTSKTWKELCFACVEASEFKYASIAAQNIIIVPDMLESLIKQYEEYNAQEEMMILLENALGMQRAHVGIFTELAVLYCHYKQKKVMEHCRQYFQKMNILKVLRTCEKMCLWSEAVYLHQHYDQPDNAINIMIEHSPTAFSHDVLVMLLQKITNTDLYYKCILFYLEEQPEQINDLLRSIQSKIDLSKFVKLMKNTGYLALTLPFLQQIQNANNKDVNDALNQLYLDIEDYENLRESVKNYENFDQLALAQKTQSHELVEFRRIAAYLYRKIQKYDLSMNLSKQDQMYRDAIETAQESQNVKLVYELLEFFIQNKESEFFTVCLYTCYDLLKPDQVMELTWRSGLMEFAMPYFIQITWELTHKIEYVQKKHEDREKKEIQTAQQQQSQALPIAQDFLLNQGQLMLGPPSQMSSSNLGFGQSSGFTNSQMNQAPMGYGGQQFGSYQPPGF
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MDSVRSVISDAEIAYNLQLIELADPSPEPSSRNDQGSSWNQASLSTSWSVVGSPTQKRSSELDLKQKEGSQSRITESDNTNITFDNELFFEIECDICTELRPHTSFISTSGCQHEYCIDCCKKHAEMKISTGKAQIPCPLPDCGHSFDIDQCSDLLSKQSLEILNTRQTEFAIPSSQKVYCPFSGCSTLMENSNGISSVYKERFVECGSCHRGFCVKCNVPWHADMTCAQYRAEMGNVLENGDEKLKDLAQRQKWQVCKVCQRFIELAEGCYHMTCLCGNEFCYTCGAKWSNGRASCNCKLFDEEHIVTPRRHGPRVRPRV
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It prefers amino acid residues with hydrophobic side chains like leucine and phenylalanine in the P1 position of the peptides substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MAARASSADRVVHVAHILLPLDQEPKAKELEEKLAGGAAFEELAREHSTCGSAKKGGELGWLSRGTFFPQFEAAAFAAPVGGITRATTGRGLHVIKVLAEKFQATIQQMNPEELYEMIHNPALLEDVQLVDVREDFEFSTSRIPGFKLMPLSRFSEWSGDITARLDPSKETVVLCHHGVRSMQMAQRRRRGLAHGVL
The following text describes a protein:
Function:
As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenesis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.
Subcellular Localization:
Membrane; Single-pass membrane protein. Nucleus envelope. Nucleus inner membrane.
Domain:
The short coiled coil domain is proposed to be not involved in load-bearing and force transmission from the cytoskeleton but in mere nucleus anchorage instead.
Sequence:
MSGRPNSRGSSRLFRAPSEDASSGSSGSAVLPQEENPNASGLTRSWKAVMGMVFILTLLLLGFINHMKLKEKAFPQKSRQIYAVIAEYGSRLYNYQARLRMPKEQLELLKKESQTLENNFREILFLIEQIDVLKALLRDMQDGLHNYSWNADIDPAEGWNHTEVIDEEMSNLVNYILKKLREDQVQMADYALKSAGASVVEAGTSESYKNNKAKLYWHGIGFLNYEMPPDIILQPDVHPGKCWAFPGSQGHALIKLARKIIPTAVTMEHISEKVSPSGNISSAPKEFSVYGVLKQCEGEEIFLGQFVYNKTGTTVQTFALQHEVPEFLLCVKLKILSNWGHPNYTCLYRFRVHGTPKDDS
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVFFGKKSPITGKQNARKTTGLKAASTRSIINKYHQLNKRKLQLQGLKKRMKKAEEQAKEAEIDAEITQIDSEMEKLGGLEVYQKASLKGQDQTRGGDSSHVLLKWLKNEGNELALEEGQEKKLLEVGCLSVSNAVSKSTEFDTIDRIDLRSNDPLIKQQDFLKRPLPKSDQEKYHVISLSLVLNFVPVTADRGKMLQLTTKFLHPQGLLFFVLPKACVENSRYLDGELFDSIMASLGYEKLEETTTDKLIYQLWRCRQEKAKYQKFTKNEVRSGSTRNNFCITL
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MPPAEPAPDFVGSLLARSPRRSEIGNDYQKWKAIADELKEANYPMNLGASIGVNRFTPELRKKARLLDRLIEGLITPLQEPTRVDAAIMNIRMAICQGLSKEEFEKLMKEHNFSLKCNVIWESDAIAYRCNTCSLTPCMSLCAACFKGGNHENHDVTRFFSREGGACDCGNEDVLKESGFCSSHGEHAERPPPPPETIVSLAELILLRLLMVVLEYFRKQRRDNPDQAVPPFMLVKDGERTIDQVCGAGKVIALIQECVDFGGPIRDAFGRILIDERMYSRIWKVPSEDVLDKHSVQSFRDFRENHKFFESVSDLTMNQDMMEEFFPEFPKELMKNTCLLHELLFWMRIHVFPQSLINLTLAFLGLTEYRDEFARRFFLLYPWTADSIRDACLHPMMEYRNISAASSRIIHVSVQMLSSAVLCSRLTTEINLPMLMFNAVAYILLKADLKPVSMMPLRKEVPGTRARRNDEIRVRRLANREAAIMRRQNERMLEDMRREGEERNEQRRRIEEREAARGGREGEDAMEVEEEEQLLGGDEGRVDIIRFDVDDDAGDMDRRLDRRAEHRLQVLAIMQRMEEEQRQEEEEEAQRQAAIAQWYTLDVAAKVLNLHGYWFAMGDTQNLLSHKEVVQKMCRDEKTLEMYFKVIEKMQCMDVINRIPSGDHLMNERADVYQRTLVLEYEMSSSSMFNLIFGIVNNGDGSGATALFDACWKSLERWFDTMDLDRAGRPLQLGKNAVSFHLPLSRHLSTILNYTCDYTFNQPSIVQRFDDLVQKKDLIHMLMLHPLRIQAARAEWGAGMWVRNGQQMRIPACLYTQTHMLFSYFVPDLDLIRFCAANLEAVDALHAIFESFSLADVFRWKKERSPSGVTYHPTTAVNLVRPEWVDTLVFGCFRLIAELVFLASVGEQTAEESMQEDIVCKLAIMNMPHSRLRQSMSEKGSHGAELVDQFFERILKRVAVFSDPEQDDTLDQGLYSLNRDAQLHFIDPLIIMGRSTSMRHAAGAFQRIDYMERRIAERPEHQFKNTWTPYRIFGMKKPISRRLPHNAGIYQLLVNHRLFETYCYIIDRYIEDWEELERRLSGVSPNNNTHEFLFKEQTIQIIIYMLTMTSLYIRLQKESVKLLDLYHKDLSDPDGPPRSLANSLISLGPVIMSMNLKRGEISKEEEEKKVKVMMREAVKKELEARLIAGTPDEYYGRLLGILYRDDTRFREMMDERYPEIVEEKMEVEAVPSPATDNTANNYIAKKKAEAAALRARIMAQKMKKDGETMKKLMESENMTQEELSRLDVSEKTVEQYECPICGDETPASFDQPIGLLVYVQFNGSYLNSIDASLPDTSLIELDEELQKDPEAAKIRYHKHAMFWREKNSEVEPMIAGENCDFIATPSMIELKTCGHHAHISCLEQYRETIYNQMRERGDLRHEIVFCPKCRFGTNGLLPLRVSTGVQENVGEKLRSGAAEGRLVVYDILMKQLFEMKKNVEDREVHEAETPSSAYSQATVKHLVEHNLSTRGSEAKQFLEDNTHIFLQGLLMTNVERNLFFDTLGVTPVRPKCIDLVSEHVNFHSALALTKTELEMTTAHVMELLIDEPEWVKSEAGILERGKKAMEGVERTHVISAQDEDQSMLESSQTSLDDEDMAILTEKTKTKDPQITILMQHALSSPVLSEKERISLFHPFLDYPTHLHFSEEWKDRCKGKPPSYYDTRFPILFANPLALVTRMTSIMMSSELTRESILESLHIICRRLVFLAAVRWTVWYCARVDYTRLKEWAEEPGGEESTPEEIIAGRPKYLHGIRRVICRLLCGSKHLSAITRSMAREELPDYDECVLMKPMNDLLVRIVQLWHEVRLVSLPEGMKSAMGMTRDQLEIVVFGNSGIGPLPTNFVAAQWTINALKPLLYIINKKRMVMYEPCTFRPFITLRLPESYDDIFARYFGRTCIRCCKVPANPMICLICSEMVCKSEIILEHICLDMCCHATNEIGESYLEPEVHPCGVQIPFLALNSALIVLVKMRIEGLTTACKALVWGSVYLDAHGEEDRNLRRGKPLKLAQKRVERFYRDFLEGEVEARYSYHNISHLPEALRDAHYIHLR
The following text describes a protein:
Function:
May function as an early signal that helps mediate the activation of T-cells.
Sequence:
MNLYLHPKLWPQLAGTKTLHVADAQRVRKITVHDGIWDAELPRAKRNHSYHLRYHGSSYSRCFLERYRCKTIGVFRRSNQPDCLETRSEKAKNRDGVVQEKSVRTLFSECVNQCDIRRRPTRFLRMFYHQKHFQLGLKGTETEKNERRL
The following text describes a protein:
Function:
Dephosphorylates D-glycerol 3-phosphate (sn-glycerol 1-phosphate). Is the final enzyme involved in the recycling/catabolism of glycerophospholipid polar heads. To a lesser extent, is also able to act on glycerol 2-phosphate and D-ribulose 5-phosphate, but cannot use D-glyceraldehyde 3-phosphate, dihydroxyacetone-phosphate, UMP or GMP as substrates.
Domain:
Crystal structures of Rv1692 reveal a unique architecture, a fusion of a predicted haloacid dehalogenase fold with a previously unidentified GCN5-related N-acetyltransferase (GNAT) region. Although not directly involved in acetyl transfer, or regulation of enzymatic activity in vitro, the GNAT region is critical for the solubility of the phosphatase.
Sequence:
MKSIAQEHDCLLIDLDGTVFCGRQPTGGAVQSLSQVRSRKLFVTNNASRSADEVAAHLCELGFTATGEDVVTSAQSAAHLLAGQLAPGARVLIVGTEALANEVAAVGLRPVRRFEDRPDAVVQGLSMTTGWSDLAEAALAIRAGALWVAANVDPTLPTERGLLPGNGSMVAALRTATGMDPRVAGKPAPALMTEAVARGDFRAALVVGDRLDTDIEGANAAGLPSLMVLTGVNSAWDAVYAEPVRRPTYIGHDLRSLHQDSKLLAVAPQPGWQIDVGGGAVTVCANGDVDDLEFIDDGLSIVRAVASAVWEARAADLHQRPLRIEAGDERARAALQRWSLMRSDHPVTSVGTQ
The following text describes a protein:
Function:
May act as a kinase regulator. Essential for progression of meiosis II and sporulation.
Subcellular Localization:
Nucleus.
Sequence:
MDFYSVKSQPFVRSPLVDQNPSIQNINEEVKRDIQNPLSYKTETSDKELCQTAACATSCSDWYPQQQTHMPHQNAFDSAKATAKMALPPTAFSNYCVKPSLTRNKDIPRTSIRVSKLRYWQRDYRLAFPNFIFYFDNVDEEIKRRVTQKINNLGAKVATLFTFEVTHFITTRTTDPEMCQPNDVLYLSKTANMKIWLLDKLLNRILFTLLNSDSLVNTSASCLQSLLDGEKVYGTSDKDFYVPSKNVEYFREYFLCIRDLSQYYKPIAVREWEKTLDSGEILWPSLAITAQGRCPFNTGRRRELKITKHNHPAHEIRKQLLSCTNQTNQNNVVKNSASVLVRQIMGDYNITESAVDGAKQMPTEFPKPENLLPVEKRAAMSPLNLLEPRLINKQNTLANQSPRQPPNAFDADPLAHKKVKIETKSGYCENCCERYKDLERHLGGKHHRRFAEKDENFQGLDDLFLLIRRPIRTN
The following text describes a protein:
Function:
Probable disease resistance protein.
Domain:
The LRR repeats probably act as specificity determinant of pathogen recognition.
Sequence:
MVVVDWLGLGLGSVAGALVSEGLKVLISEAKKVLAFKSVSNELASTMESLLPVIKEIESMQDGMELQDLKDTIDKALLLVEKCSHVEKWNIILKSKYTRKVEEINRKMLKFCQVQLQLLLFRNQLKSMPSMEAILNNYFQNINKKLDRLSGSPAPPLVSKRCSVPKLDNMVLVGLDWPLVELKKKLLDNSVVVVSGPPGCGKTTLVTKLCDDPEIEGEFKKIFYSVVSNTPNFRAIVQNLLQDNGCGAITFDDDSQAETGLRDLLEELTKDGRILLVLDDVWQGSEFLLRKFQIDLPDYKILVTSQFDFTSLWPTYHLVPLKYEYARSLLIQWASPPLHTSPDEYEDLLQKILKRCNGFPLVIEVVGISLKGQALYLWKGQVESWSEGETILGNANPTVRQRLQPSFNVLKPHLKECFMDMGSFLQDQKIRASLIIDIWMELYGRGSSSTNKFMLYLNELASQNLLKLVHLGTNKREDGFYNELLVTQHNILRELAIFQSELEPIMQRKKLNLEIREDNFPDECLNQPINARLLSIYTDDLFSSKWLEMDCPNVEALVLNISSLDYALPSFIAEMKKLKVLTIANHGFYPARLSNFSCLSSLPNLKRIRFEKVSVTLLDIPQLQLGSLKKLSFFMCSFGEVFYDTEDIDVSKALSNLQEIDIDYCYDLDELPYWIPEVVSLKTLSITNCNKLSQLPEAIGNLSRLEVLRMCSCMNLSELPEATERLSNLRSLDISHCLGLRKLPQEIGKLQKLENISMRKCSGCELPDSVRYLENLEVKCDEVTGLLWERLMPEMRNLRVHTEETEHNLKLLLTF
The following text describes a protein:
Function:
Protein required for the cotranslational protein quality control in the inner membrane of the mitochondria. Associates with newly synthesized polypeptides and may act as a chaperone that cooperates with OXA1L for the insertion of newly synthesized mitochondrial proteins into the inner membrane. Required for the assembly of the ND4 module of mitochondrial complex I.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MGVWQSGLKMEHNQDTERRLSINEIIARRVKQLPQGDQNLFMTGSAYVGLNAAFCGLIANSFFRRVLNVTHARIASALPMAVLPFLSTHITYQNAVSLPLSSGNLSCELCTLLRGGLTGMIIGGIYPVILAIPINGALAARYNSAPLPQRGNIWTYWITVSQPIFKKMVFPIMLQTVFAAYVGSRQYGVLIKALELPETGI
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MREEPRPRPPPSGLAGLLFLALCSRALGNEIQGLKLPGGGEPPLTANTVCLTLSGLSKQQLGLCLRSPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFSHSLPSSGPGSGPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQLKTCWRAPPEFRAVGAALRERLDRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFENSPDFCERDPTVGSPGTQGRACNKTSHQLGSCGSLCCGRGHNVLRQTRVERCNCRFHWCCYVLCDECKVTEWVNVCK
The following text describes a protein:
Function:
Possible transcriptional regulator (Probable). Involved in promoting segregation of chromosomes during meiosis, perhaps acting downstream of the let-60 RAS / mpk-1 MAPK signaling pathway.
Sequence:
MDYVNRNLDDKLLCGICGKYFSDDESLREHRRQRHMTCHMCLLCNRRIPENETLREHMKNKHNIWKLFICVCCNWSFGTEIYLKCHEECMKSTGRPGLLKPLAMPMTAPAREASALNTDPQNGSDDVPHSSPSPVPMIAENSIIQASSLKMEPIESADRSSASTSTPRTLVSGTPREKIPCGFCGKDFFHEGSLREHRRRFHMTGHTCLLCNRQIPENETVRDHMKSQHNIKKVYNCLCCNWTFLNQVHLISHKTCLKQTGKPCCRPGHMEPLAIPRTASIRQFFTLKTETQSGDDDSAAGSQLFSARLSCKSCGKFFYSERSLSKHHRQIHMSGHVCVLCNHQMPKTVTVQEHMEKEHNIRLVFNCRCCNWSFATRRCLMSHVECLKKAGDARNVKPVAIPRMAADSILQSLKESEAQEYPDFSAASTTSSGPASTLKTPRMDFKKNLKICTDAVQILVGNGLFSNEQLAQTETWVMIFSNANKLFHSMNSFGEPSVSRDIPM
The following text describes a protein:
Function:
Involved in AFD-neuron mediated thermotaxis. Regulates behavior to environmental temperature. Thought to have a role in olfactory adaptation by affecting diacylglycerol levels.
Sequence:
MLLSPEQFSRLSEYAAYSRRKLKDMLSDFQQDGKFYSYLSVDGQTINIDGFRAFLIDYFGADLPSDLVDQLFLSFSKPPIKERRTSLFEDAISTVRAKFSESLSGRMAGLNIAGGSGQQTDRSQSSEPQALVCIPEDDVMGPRVANNDSQEPRIPLKPLICTLSLLEADTPENKLDVVFHVYDSDGNGFLDKSEIDGIIEQMMNVARYQQWDTIELEQVIRQMMVDIDYDNDGIVSFDEWRRGGLTNIPLLVLLGFDTEMKEDGSHVWRLRHFTKPTYCNACCSILVGWGGKQGLSCSLCKYTVHERCVRSAATNCIRTYSSRQQDKLYHHWQDANATAKCVKCKATVGVFQGKGCRWCHNYVHHRCMSALAQECDLGALVHHILPPTHIFPAFLERKTSTSLKNHNFSSHSASLLQAVSPSNDCRPLLVLVNPKSGGKQGVKILQKFEYLLNPRQVYDLSKTGPEPGLQLFSTLKNCNILVCGGDGTIGWVLESMDKMTFPHGRPPVAVLPLGTGNDLARCLRWGGGYENENLHKILEQIEKSSLIDMDRWQIKIEITENKSARRASEKGDTPPYSIINNYFSIGVDASIAHRFHVMREKFPEKFNSRMRNKLWYFELGTSETLSSSCKNLHEQIDILCDGESIDLGQDASLEGIALLNIPSIYGGSNLWGRSRKSKGRMPGLFPMKNAEKMQLQTRVQDIGDGLIELVGLESAMQMGQIKAGVRGARRLSQCSTVVIQTHKSFPMQIDGEPWMQPPCIIQITHKNQAKMLVAAAPRKRSSWMLLKRQSTNDDN
The following text describes a protein:
Function:
Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
Sequence:
MLHELGVIIEVVKTVEDIAIKNHLTKIDTIVLQIGELSSMIPKYIEECYPAAVDGTIMESTKLKIEILPGNALCKKCNKVYNIMANRRGCPYCESREWELLCGKEFLIKEILAY
The following text describes a protein:
Function:
Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic. Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis.
Subcellular Localization:
Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
Domain:
The coiled coil domain mediates the interaction between MTMR3 and MTMR4. It is essential to bring together CEP55 and PLK1 during mitotic abscission.
Sequence:
MRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEYVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFPTFEQCQDWLKRLNNAIRPPGKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVAGFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSQSSVGKVSTRNSCRGFPNAGDLSDVEFDASLSNASGTESLALQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDRDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTVEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKQTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPSTPTDDSCAPYPAPGTSPDEPPLSRLPKTRSFDNLTTTCDNMVPLASRRSSDPSLNEKWQEHGRSLELSSFAGSGEEVPAIDSLRRPSRLLGGAELSVAAGVAEGQMENILQEATKEESGVEEPTHREHTEVPEVKEEAPLAKESRTAAQGSGVLYQEPQLDDATLRSHLGPSLSSFSQGIPEHREVGHSVLSSSLPASLRGEDSQEVPVEQPQVENIAEDRENVVPAVPVDVKIGLGTSESSPLLPSQVPFETRGPHMNNSVHMLLEDKVKSESGPQLHHRPCLASSGRFSGKDMLPIAPEPRSAERPQWDSVLHRTSSPGNTLSLMMQAPCALPLDKCRQRIVCNGALETENKASEQPAGFDTLQKYPTPNGHCANGETGRSKDSLSHQLSATSYSSAHSCSRNLHHKWLNSHSGRPSTTNSPEQPSRSHLDDDGMPVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLRFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
The following text describes a protein:
Function:
Transcriptional activator involved in abiotic stress tolerance. Can directly regulate stress-related gene expression by binding to the DNA sequence 5'-[AG]CCGAC-3' (DRE element) of their promoter region. Involved in the regulation of stomatal closure movement under drought stress. Acts as a positive regulator of drought stress response.
Subcellular Localization:
Nucleus.
Sequence:
MATAKNKGKSIRVLGTSEAEKKDEMELEEEFQFSSGKYKDSGPGSDMWLGDASSTSPRSLRKTRTFDRHNPYLVSSYATPQPPTTTTCSVSFPFYLPPAIQNQQRFLHPNDPSGQRQQQMISFDPQQQVQPYVAQQQQQQQHLLQYWRDILKLSPSGRMMMMNMLRQESDLPLTRPPVQPFSATKLYRGVRQRHWGKWVAEIRKPRNRTRLWLGTFDTAEEAAMAYDREAFKLRGETARLNFPELFLNKQEPTPVHQKQCETGTTSEDSSRRGEDDSSTALAVGGVSEETGWAEAWFNAIPEEWGPGSPLWDDYHFPISNHKDDLDATQNSSSDTI
The following text describes a protein:
Function:
Catalyzes both the N1-methylation of guanosine and the C7-methylation of 4-demethylwyosine (imG-14) at position 37 in tRNA(Phe).
Miscellaneous:
MISCELLANEOUS: Less efficient than Trm5b and appears to be selective for methylating tRNA(Phe).
Subcellular Localization:
Cytoplasm.
Sequence:
MSGVKVRREDAKKVLELLKSVGILDGKRKAIRDEKYVIFPVTDTNIAKSLGLEVVDVELPMRPERQIYKNLEDLLPREIFKKLGRLDIVGDIAIVSIPDEILSEREVIVSAIRKLYPKVKVIARRGFHSGLYRIRELEVIWGENRLHTIHKENGVLIKVDLSKVFFNPRMKGERYRIAQLVNDGERILVPFAGVIPYPLVIARFKNVEVYAVEINEFAVKLAEENLELNRDRLKGKIKIIHGDVFEVLPNLPNFDRVVSPTPKGVDALSLTLSKAEKFLHYYDFVHESEIERFRERVLEECRRQGKECRVSVRKVSDYKPHVYKVCADVEILS
The following text describes a protein:
Function:
Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MFSIPVSSKTVRLILVSLLLITLINILAAFQRSTLSSWFPSSRHIINKFTDLRLALSSQESVLRDEEGEIYSLVGYHHDFDSNLVVVQKQYLLEKTPNEDTTEHFWNFLQSNFETKSEYDLNLIDGYNYKKLIKHLNEQNELQLSHSFVEQYKMENQFIQSFQNFFVQLIDTIEDCKPDLDPINNDNHYPNGDKIVKYYELRNKIPSENMKQFNIERLIHRNGRIPIYGGHLREQYKDELIRNKEFLSMYLTLSDSEISALKKSHTKFLETMMENWPENLFKFNKFNNFMKGDGIVYLGGGKYNQLVLLSIKILRENGSRLPVEVIIPYKNDYDIQFCDRVLPTLNGKCKLMTDYLPQTFVDKISGFQLKNIALLISSFERILYLDADNIPIRNPDVLFTNAPFTTKHLVVWPDLWRRSTSPHYYTIAGIEVDPNFKVRNSYVDGDERGKYTDSMYYSYHDCKGSIPEASSETGQLLINKKIHFQTLILAMYYNYYGPDYYYPLFSQGAAGEGDKETFIAAAHKLDLPYYQVGEFNREFGPINDNTRKHEFYGMGQYDPIIDYYMSTITTTQKDTKKKINYNSPLPEKYAANDEDDTCSNYDFHLFQSSSLFFLHANWPKYYIEKLFLYSYDEDRGPVTNDGDKRRLYGNELKKELGGYDFELNIMKNLHWCFCEEPLIDLIGIPVVGSKTRTDVCIAIKNHIEFLEIS
The following text describes a protein:
Function:
Involved in the biosynthesis of pulcherrimin, a red extracellular pigment. It uses activated amino acids in the form of aminoacyl-tRNAs (aa-tRNAs) as substrates to catalyze the ATP-independent formation of cyclodipeptides which are intermediates in diketopiperazine (DKP) biosynthetic pathways. Catalyzes the formation of cyclo(L-Leu-L-Leu) (cLL) from L-leucyl-tRNA(Leu). Can also incorporate various nonpolar residues, such as L-phenylalanine, L-leucine and methionine, into cyclodipeptides.
Sequence:
MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFSEDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAERALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRARGVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHEFSICMRPNQGYLIVQEMAQMLSEKRITSEG
The following text describes a protein:
Function:
RNA-binding protein which binds to its own mRNA and target mRNAs to negatively regulate gene expression to modulate apoptosis and differentiation in the germline. Negatively regulates the expression of the argonaute protein wago-4, and may thus play a role in RNA-mediated gene silencing (RNAi) in the germline.
Subcellular Localization:
Cytoplasm, perinuclear region.
Domain:
The KH-like 3 domain is required for binding to RNA.
Sequence:
MDDSTPYPVPQELYIPQKMKAFMAEPQGCALVAALEGQFQCSIVVINDHLSVISSADGVAVDINQIEKILRDVWRKRDVQIMIREAALNASCTHICHTLLPRAYCAVVLFFSSDLQRRSRCTDIIIDQFTGKVTMFGTEQAVNKAREMMIECLTEHFGLLEMNIPPTQRTTRMGYTNSYNPEIRTHLPPNSFLNSVFPMGEPNAILTSTPPTTSIMDEPLLSASLEKHLLFPSDFSVPPPRLSPVQELPLTPPKTCVVEKIKQWIPTTEVGKILGNRAAVKKHIERQFNCVITVHTEVQSSFGATPVEIVAQNKEQCQEARNAVMSLMQSHQDKPASNPPDSGFSTPGSPFTSDSSSTTPEKRGNSRQYHRGSFRDQPKVMLALTPRKLSPSD
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MGESMNSCLEEINGCLDSITSLYFKPPGIFHNAMIRISKDGKETHTLNDKIKNLIKGCDPKEETTLFQLDPVTKSLRRKDGRQALFDYLDKRDLNMKRNRRLGHKDEKPVIHVPNEFYIREHDEELLRDSQRTKRFKAAGHGNDIDSNNTNNTTTALITELFNDDVGLMATMRKKFKENDEIKNLLMALQKGSVILDEKEGISTNNRRRTLFVEDFSTESILKLLDAVLEMFPTEEYKKAAEQYHDVFQELNEESEKLLAEIQLQKDEIEGRLKIESSKDSTTGVQKLIEKERQKIAELESQLRISN
The following text describes a protein:
Function:
Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.
Sequence:
MAAQAVEGAAVTALRTVFQRVRQAAERSGRVADDVRVVAVSKTKPVSLIRQVYDAGHRCFGENYVQEFIEKAPQLPQDIDWHFIGHLQSNKAKSLIAAVPNLSMVQGVDNEKIANHLDRAVSSIGRRPLPVMVQVNTSGEISKSGIEPSHCIELVKHVKFGCPNLVFSGLMTIGMPDYTSTPENFKTLSRCRVEICRELGMPENQCELSMGMSGDFELAIEMGSTNVRIGSTIFGPRDYSKKQQQQ