lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MSAARFAARSFLSRRLAATVPAAAPAASTPAASTCPAAQQQQSQFHSSAHLEARRRSRFKNVRAVEMGLTSDAKIESFTKKKFAEYTEDEKAALAHNYPAEHMEAIEAAEAAIDPKDLTIQGRLRVDPYRMPYIDDFSEIQPIIDKRARRSAPPSHKARFMDVDEFTQDLINWADEIRRGEPTHRMKKLRDFVPEEFFEKPEGQWPKDVRDEAFTKFWAYLKEQKDADAKAAANATGPTDGDILSYILERSSMTDNNLQANSSLAPALPDKVPGVEGKYRNAIDPADDGLDDKGQYQELKKRTGMSVRQILQLKTKKLVHRRVVNQTRLGKIASDSVMVIAGNGDGWLGLGMAKSVEASIAVEKATLLAIQNMQPIPRYENRTIYGEVTTKVSGTIVRLNSRPPGFGLRVSHRIFEMCRAAGIRDLSAKFLRSRNPMNTVKATYQALLSQPNPEDLAIGRGKKLVDVRKVYYGGSVY
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MSSIISVANLSKTYGSGFKALKNVNLDIKRGEIFALLGPNGAGKTTLISIICGIANPSEGRVLVGGEDIQTSYRKARSLIGLVPQELHTDAFESVWATVSFSRGLFGKPKNPAHIEKVLKDLSLWDKKDSKIITLSGGMKRRVMIAKALSHEPQILFLDEPTAGVDVELRKGMWEVVRTLQQSGVTIILTTHYIEEAEEMADRIGVINKGEIVLVEDKATLMQKLGKKRLTLHLQNKISALPESLGHYELDLCDSGATLVYDYDTKGERTGITSLLSDLRTAGIRFNDLDTTQSSLEDIFVDLVRTS
The following text describes a protein:
Function:
Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets. In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
ACVERAARPVRGEVRGHEEWPRAGVLEESAASASARGVWGELSTSVRLPQIPPTPSHSFFPRAPAASAKPGEADPSRRARTSPSQQEGSLGRSAAPHGLRVRCSHAAPGAESSLGIRRPAWSAPAQSPGASTSVSPPRPPAGAKALAGPCSPAPAPVGFPGGTAVKCACSALAAQCLPVWIPSVDVAPLGTPCCDKAPLSKSLLLVPSALSLLLTLLLPHCQRFFVYDLQAVKDDFQIWRLICGRIICLDLKDTFCSSLLIYNFRIFERRYGSRKFASFLLGSWVLSALVEFILVEAVRYSFGIAAARNLPSGFLAPVFALFVPFYCSIPRVQVAQILGPLSITNKTLIYILGLQLFTSGSYIWIVAISGLVSGICYNSNVLRVHQVLCIPSWMAKFFSWTLEPIFASSEPATEARIGMGATVDIQRQQRMELLDRQLMLSQFAQARRQRQQQGGMINWNRLFPPLRQRRNINYQDGRRSEQQASPPLEVSEEQVARLMEMGFSRGDALEALRASNNDLNVATNFLLQH
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Sequence:
MRRSSDPSANKKKWTKASNWRPRMVRWQRQLARVNALESTLQAEDDQTIRKRSLALRYRAMAGEKLSELLPEAYALCREAGRRSLSMRHYDVQILGGIALFEGHITEMQTGEGKTLTATLPLYLHSLVGKGAHLATVNDYLAKRDAEWMMPLFEMLGVSVGIIQTEDDQGGRRKSYGAAITYGTAKEFGFDFLRDRLLLRAQNRMQTEMLGSGDGGFSNSGDQVVMRGMHFCLVDEADSILIDEARTPLIIGSIEDTVRDQIIETYKWAAENAPLFELDEHFEIDDETKRYELTARGRSKVRALPKSDLVRTMGLVDMYEYIERSIKTHREFLLDRQYVIRPSEKDPNVDEIVIVDEFTGRLAEGRKWRDGIHQSIEAKEGVEISVPTGQAARITVQDLFLRYPHLAGMTGTAATSAGELRKIYRTPVVRVPTNRPPQRIQLPSRVFGTLTSKFEAIAKEVEEIHATGRPVLVGTRSIDKSVLLSKLLDDLGIEHEVLNANNVEREAEIVAEAGGRGKVTVATNMAGRGTDIKLSNDVEQIGGMHVICTELHDAARIDRQLIGRCGRQGDRGSYRQYLSLDDDILKGGYGAIKYEKLKKRGEATSGSVDRLAAMFHKAQRKVERRHFRDRMVLMHHEKERKKMQREIGQDPYLDTPD
The following text describes a protein:
Function:
Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH.
Sequence:
MNLRKNVIRSVLRGARPLFASRRLGIAGRRVLLATLTAGARAPKGTRFQRVSIAGVPVQRVQPPHAATSGTLIYLHGGAYALGSARGYRGLAAQLAAAAGMTALVPDYTRAPHAHYPVALEEMAAVYTRLLDDGLDPKTTVIAGDSAGGGLTLALAMALRDRGIQAPAALGLICPWADLAVDIEATRPALRDPLILPSMCTEWAPRYVGSSDPRLPGISPVYGDMSGLPPIVMQTAGDDPICVDADKIETACAASKTSIEHRRFAGMWHDFHLQVSLLPEARDAIADLGARLRGHLHQSQGQPRGVVK
The following text describes a protein:
Function:
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Sequence:
MFELISGTKRLSLASPVVMGILNVTPDSFSDGGKFSSFELACQHADEMVAQGALIIDIGGESTRPGAADVGVEDELARVIPLVEYVAKHHDVWISVDTSKPEVMRQAVNAGAHLINDVRALLEPGALETAAQLNVPICLMHMQGAPRTMQAAPEYHDLVADVSEFLNERIQACLEAGIPRERLLIDPGFGFGKTLAHNYELLAKLETFTQFELPILIGLSRKSMIGNLLARPTSERLAGSLAGAMIAAQKGAHIIRVHDVPETVDMLKVLQATQAYY
The following text describes a protein:
Function:
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity). In monomeric form may have additional moonlighting function as serine protease (By similarity). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.
Miscellaneous:
MISCELLANEOUS: The active site is a redox-active disulfide bond.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation.
Sequence:
FNRXSPGLQGVSSVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHLAHGKDFASRGIELSEVRLNLEKMMEQKSSAVKALTGGIAHLFKQNKVVHVNGFGNITGKNQVTATKADGSSQVIGTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKLVVIGAGVIGVELGSVWQRLGAEVTAVEFLGHVGGIGIDMEISKKFQRILQKQGFKFKLNPKVPGATKRSDGKIDVSVEAAPGGKAEVIPCDVLLVCIGRRPFTQNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFR
The following text describes a protein:
Function:
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKFEEEVLTKLSSLRKGLIHGDANTSNIIMQQLLGGDGMDQCWGVCGVIDFGDSHCSYCVFEVAIMLTYLMVKAVKCNCDMFTVAEYGLKGYQTVLPLGDKEKDILYIVIAQRCVQSLSSASKEICDQPENTDYIMMDFSAVKTVLLNVKDRIKLV
The following text describes a protein:
Function:
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Sequence:
MSAVTPAGGDTTADRSWPALLNGLLDGRDLSADDTAWALDVIMRGEATDVQIAGFAVGLRFKGETVEEISGLVRTMYEHANVIEVPGKTVDIVGTGGDGAKTVNISTMSAIVLAGTGAKVVKHGNRAASSASGASDVLEKLGVNLELTPQRVAEVAEEAGITFCFAVKFHPALRHVATARGQLGIRTVFNFLGPLTNPARVKAQAVGVAHARMAPIVAGVFAERGHSSLVFRGDDGLDELTTTSTSRVWVVRDGRVTEETFDPRDVGIELVPVEALRGADASYNADVARRLLAGEKGPVRDAVLLNSAAALEALEPGEGALAERLRAGMDRAAEAIDSGAARRVLERWVAVSHA
The following text describes a protein:
Function:
RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation. Shows a preference for uridine-rich RNAs. Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1. Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
Subcellular Localization:
Nucleus. Cytoplasm. Cytolytic granule. Cytoplasm, Stress granule. Note=Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (By similarity). Accumulates in cytoplasmic stress granules (SG) following cellular damage.
Domain:
The RRM 2 domain is required for the binding to target RNA, and the RRM 1 and RRM 3 domains seem to contribute to the affinity of the interaction with RNA; The RRM2 domain and the C-terminal residues 290-339 contribute to nuclear localization; The RRM3 domain mediates nuclear export and cytoplasmic localization in a manner dependent on RNA- binding.
Sequence:
MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
Sequence:
MPPYLYRLPTTSLITFSAILNDPSSSYTTILSDATASRTKLHLALKGIADNEPGASALAVLDAVQIYLPYLKGIIACLDADELLFKGEPTFQWRAPLTHFSFSSPLLPLASIHSEHLMVVLTYALALSNYAHSILASLPAFEIPAGPKAMPHMSSEDEKRTTAGLARAVDLLCQASGVAEWAAENVCLQVEPLKGVSSGRLGKGKWPAESSRETFKALSMILLADAHLTAIRKLLFPVLTYTLFAPPGPPLPPNHPSAPLQAKLYLYVHQLYSSARALLSVHHQPTSSAPSNSSRKLFRSNTDKDVIEPEAVEGEIIPELKRYLAKEAQLALALAHKWLGIDAGENGKGAKVGEALAWVKDAQGRLEDLEDSKMRAKLKGLSIGKSRERKKEERRARMGRVERELEVVKAWVKAYQKMNDTVAFQPVPPVSSLVTPSGRPIFGPKAFIPPPSKFSPSRIGHLNEEQGNDSPELGETEDTSYAGKGNYF
The following text describes a protein:
Function:
Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling.
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MEATGTQRLSPTVSSQPVVLQCAVCSDHATFKTRMELGRHLRERHCAKEGGSFVCRYGANGVCPTLPLEGVSDKDYVDHVVKEHLSRDGAISTLQRSSSQTSPSPSPSASEPSVVTDQQKWTVYNSQVNLAAVLNDPRRSRREHDFFTKTWGEDFIEIGPEDIHPSFYLPNITKAHFEHYLKSARHRYAVHQQNKHKLPTNSPPSAQTLAPLPRHLDKGKADLEQVPKIFMQPNFALENPATFNTVLPWSQFEPPKDKEQGRQSSKLLQEKLSHYLDIVEVQIARQISYRSEAFFSAMASHDELQDNMTHCLSAIKQLRDRIHNIDSVLAKGSLQLLQLSRSRQNYTKLYHMMKMMATVHQTQPMVQVLLSTSDFVAALDLISITQQVLAKDLAGIQSFRHLGLQLCELERVIDRMMQEDFQRYAVENLARPKEDGIQLFEEERLTSLVYGLLRQHRFEFLEVMREEAATAIKAGIKQTVAEFVSQVDTIDNESVGSLADQMRMLNFQQWLAMLGEVFTKLLLLVSRVKMTAAVIQGVIHLAAGRGHCTTEVGVALGVSKASRPVSTSTSQSSKPEAEAPDDNGPLENSHEEFVSEENRVLGFHDDHVLTNGDIAALSNSEELRTKERESRSSVDRTAENSEEKAQQNGVDRTEQHSELTANDVAGTTRDDLTENCSGSVDDEDGEDVGYYLEDSEHTVYLSETDYVKVSVTLKDLLCFLCDHAHDRCLKLLMARSKDGFLERLTSSEFVQLSRAIEGFVKDCEQVCGRRSTSLRGGLQSQANRFVNRFHEERKTKLSLILDSERWKQTDVPVEFQDLVNSVDKGVIPSPTTKQNSITEKKPTEYLVVDGQKFAVVGTVLLLLKMVLEYCQCADDLPSATPDILTRLVELLKHFNSRSCQLVLGAGARQVVGLKTITTKNLALCSRCLQLMVHHLPIVEEHFRARLQHKQQPMLKSFQQVIKDYNDHIQEIASKLIAIMDDMFEKSLAKWEAKAPMPSSTFRTICKQISKLHEAIVDLLPPEQIRVLFTRINVSFKSHLQQQLVRLNVTNDGGPQHGLVQSDVAFYSGHMQSLRDLTDVDLHMQDIWDR
The following text describes a protein:
Function:
Involved in gametogenesis and steroidogenesis.
Subcellular Localization:
Secreted.
Sequence:
MISRVSRVMFLLMLSFILGTSTFLWSLAPAAAFQLPYCQPVKQKLSLQKEGCSGCHTVETTVCSGHCLTKDPLMKIRSIQYQNVCTYRDFYYKTFELPDCLPGVDPSVTYPVALSCHCGACIMNASDCTFESLPPDFCVKHDSFYY
The following text describes a protein:
Function:
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
Sequence:
MDRRDYTKIRVGLGYDVHPFEEGRELFLGGIKIPFDKGLKGHSDGDVLIHAIADALLGASALPDIGYFFPVDDKSIEGIPSTIILEKVRDLLKEKGVNIINIDCTIIAEEPKIMPFRDKIIKNLSSILRIPEDCLSVKATTNEKLGFIGKKEGIAVFAVALVSY
The following text describes a protein:
Function:
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Subcellular Localization:
Cytoplasm.
Sequence:
MLILQAERDSLLKPLQAVTGIVERRHTLPILSNVLIEGKGGQTKLLATDLEIQIDTAGPEGGAGDFRITTNAKKFQDILRALPAGALVSLDWDDSRLTLKAGKSRFALQTLPAADFPMMNVGEDISATFSLEQERFKTMLSQVQYSMAVQDIRYYLNGLLMQVEGSQLRLVATDGHRLAYAACAIDADLPRAEVILPRKTVLELFKLLNNPDDPIQIELLDKQVRFQCNGTTIVSKVIDGKFPDFNRVIPLDNDKIFVLSRAELLGALERASILANEKFRGARLFLQPGLLSVVCSNNEQEEAREEIEIAYQGGELEVGFNIGYLMDVLRNIHSDDMQLAFGDANRSTLFTVPNNPNFKYIVMPMRI
The following text describes a protein:
Function:
Clostridial collagenases are among the most efficient degraders of eukaryotic collagen known; saprophytes use collagen as a carbon source while pathogens additionally digest collagen to aid in host colonization. Has both tripeptidylcarboxypeptidase on Gly-X-Y and endopeptidase activities; the endopeptidase cuts within the triple helix region of collagen while tripeptidylcarboxypeptidase successively digests the exposed ends, thus clostridial collagenases can digest large sections of collagen (By similarity). The activator domain (residues 57-330) and catalytic subdomain (340-611) open and close around substrate allowing digestion when the protein is closed.
Subcellular Localization:
Secreted.
Domain:
The mature protein has 3 domains; a metalloprotease domain (S1, approximately residues 53 to 727) and 2 collagen-binding domains (CBD) (755-872) and (882-991). The metalloprotease S1 domain is composed of 3 subdomains which together resemble a saddle; an activator domain (residues 57-330), the catalytic peptidase subdomain (340-611) and a helper subdomain (619-731).
Sequence:
MKKKFIKMLCSIAIGCMISTSYSIKVSAFSNGNTKTNPNGEFKSLSLNSTNPYKTKYSFNDLNKLSNKEILDLTSKIKWSDISDLFQYNKDSYTFYSNKERVQALIDGLYEKGCNYTSTDDKGIDTLVEILRSGFYLGYYNDSLKYLNDKSFKDKCIPAMIAIENNKNFKLGENGQDTVVHALGKLIGNTSCNDEVVNKTIPILEQYYNEIDKYSKDRLKSNAVYNFMKEINYDISQYEYAHNIRDYKNTPWSGKIDSFIDTISKFASISNVTKDNGWIINNSIYYTAKLSKYHSNPSIPHSVIDNCIEIFPDYSEQYFTAIEAIKEDFNSRDSKGNVIDINKLIEEGKKHYLPKTYTFDNGKIIIKAGDKVEESKIQKLYWASKEVKSQFHRIIGNDKPLEVGNADDILTIVIYNNPEEYKLNKTLYGYSVDNGGIYIEGIGTFFTYERTPQESIYSLEELFRHEFTHYLQGRYLIPGLFNKGDFYKGNNGRITWFEEGSAEFFAGSTRTSVLPRKSMVGGLSKNPKERFNADKLLHSKYSDGWDFYKYGYAFSDYMYNNNKKLFSDLVSTMKNNDVKGYEALIEESSKDSKINKDYEYHMENLVNNYDNYTIPLVSDDYMKQYDNKSLHEIKSDIEKAMDVKNSQITKESSQYFDTYNLKATYTLSSNKGEISNWNYMNNKINEALNKLDNLSWGGYKTVTAYFSNPRLNSNNEVVYDIVFHGLLSHNKNSNEKVEVKEEPEIKDKDSFENVIYEKENNDSFDKANKIHKNQIVMATLDTEDYRDTFYFDALTSGSIDITIENIHGNSDAFNWLVYNDEDLNNYIAYPTKKEDNKLMGSFKVHKPGRYYILVYKTSLNKVNYKLNISDATNMAPVIKKIHEKENNDSFETANKITLDTLVLGNLDYKDVSDIYSFDIENTKDLNIKLTNLNNLGIAWNLYKESDLNNYIAYGAKSDNAIVGKCNLSPGKYYLYVYKYSGDKGNYSVIIN
The following text describes a protein:
Function:
Functions both as a mechanical stabilizer (via LIM domains) of focal adhesions, and as a sensor component for muscle cell damage (via N-terminus). Regulates, stabilizes and maintains posterior lateral mechanosensory (PLM) synaptic branch extension and new synapse formation and growth during larval development.
Miscellaneous:
MISCELLANEOUS: [Isoform b]: Produced by alternative promoter usage; MISCELLANEOUS: [Isoform c]: Produced by alternative promoter usage; MISCELLANEOUS: [Isoform d]: Produced by alternative promoter usage; MISCELLANEOUS: [Isoform e]: Produced by alternative splicing of isoform a.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, myofibril, sarcomere, M line. Cell projection, axon. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Shuttles between dense bodies and M lines. Localizes to nucleus in body wall muscle cells. Highly mobile in cytoplasm. Mobility seems to depend on atn-1.
Domain:
The LIM domains are sufficient for the role in PLM synaptogenesis.
Sequence:
MGPPPPPPPPPLLPSGEILPSRKWKTEDAPRRNNHPAPAPPKPSRPTVDASALQHAAARLRKTGYNEPVRGDVENLSDGRLDRPHQQLPDGDRTYRANLQQLAQPKTRAEIPSPPTYSNQPRPLGDFHRDPNALSQFQQSREALLSSTSPTSNYSPINKFSSSTLTQYANKSPSPPSFGNSNSEATYVSPYSSKHSYPTNFRSYHKDDDYFNNTATTATTTTSSNSLNENNNSNKYGNKETVLQWSEPYDPSKIRRSQSPIRNAREMIHEYSTTNYVTEVQQPPPPPPDLYQRMTQARTFLQNSLAKQLRDEGLTESQKAANRNQTGALSASSSIPFDASQIVKNSYNGDEVDHLVHQMRTKLNQPADTSPSIVQYPRRQAPDSSRANYSATTSTSFSSSTTRKIMNINICVGCGKEITGDQPGCNAMNQIFHVDCFKCGQCSKTLAGASFYNIDDKPTCEGCYQNSLEKCTACNRAISDKLLRACGGVYHVNCFVCFSCKKSLDGIPFTLDKDNNVHCVPCFHDKFAPRCALCSKPIVPQDGEKESVRVVAMDKSFHVDCYKCEDCGMQLSSKLEGQGCYPIDNHLLCKTCNGNRLRVVSST
The following text describes a protein:
Function:
GTPase component of the GTPBP3-MTO1 complex that catalyzes the 5-taurinomethyluridine (taum(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs (mt-tRNAs), which plays a role in mt-tRNA decoding and mitochondrial translation. Taum(5)U formation on mammalian mt-tRNA requires the presence of both GTPBP3-mediated GTPase activity and MTO1 catalytic activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MWRVLWTLVARAARGPLSSRPCPRQSSGAPALGPGSTIFALSSGQGRCGIAVIRTSGPASGHALRSLTAPRDLPPARKACLRLLSDPCSGEPLDRALVLWFPGPQSFTGEDCAEFHVHGGPAVVSGVLQALGSVPGLRPAEAGEFTRRAFAHGKLSLTEVEGLADLIHAETEAQRRQALRQLDGELGHLCQGWAETLTRALAHVEAYIDFGEDDNLEEGVLDQADSEVRELEVALGTHLRDARRGQRLRSGAHVVVAGPPNAGKSSLVNLLSQKPVSIVSPEPGTTRDVLETPVDLAGFPALLSDTAGLREGVGPVEKEGVRRAQKRLEQADLILAVLDASDLTSSSSCNFLDTVVIPTVAGSPHGSSQRLLLVLNKSDLLPSGGPDLHPDLPPYLLLSCLTGEGLDGLLEALRKELATLCGDPSTGPPLLTRARHQHHLQGCLDALGHYKQAKDLALAAEALRVARGHLARLTGRGGTEEILDIIFRDFCVGK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAARIEKLLRDVDGLYWIRAHWYMILFSTPQRDAPPVQLSPKYPDPPPSAPTTTATNDPTAAFREQPKKLRADFVKAAKQVENDVTGQELQKQFEAAVVKAVIEVMNLISTHRASLAVAHGNG
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MQEIIKCREQLEKAIKDGEFDKALECLKNAKNFKITKDLLKSTDIGKSVGKLRAHKDIGISSQSKELIDKWKQDIEGTSATTTSSSSSSSSSTTSTTTTKTASPSESLKRKSISEDTSDRPTSKPLLQENKKISPPTTPKTSSPPIASLIAPITGANADLRNKTIQLFVEALTTDNDETMSPPEDIAVEIEAEMYDIYRGVSKEYKEKLRSFKFNLKKNDILRLSLLNRQISVAKFCSMDIYSMASDDLKEERKKLDKFNTEASMLGQNNEATTDQFQCGKCKQRKCTYTQLQTRSADEPPTTFVKCCVKGCGNRWRFC
The following text describes a protein:
Function:
Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.
Sequence:
MGVALCHITDDEDSVLPPPPRYPSQAAYNLAVQNGMAAPMIETNNLLKHPEGLQLLAGEGTYLLQDDLHLATPPPHPSETPNLNPNPLSTAPQAATAGTKLSLLSFSTKPSAPLLYRLDTNKSSRTGLAQSSIQEHPYENRTSSDIPGSSDGGGTSVNGSARVAPSIGSAPAFGEGNSLLSFTGKDSGKRRKPKSGILKTSHMDGSLIAYDKEKDDASFVPEEVGPDTNGSVPSEENLDPTSTPKAKLQIDKSVHSKNQKFNPVSYWKLSNQPINNFAFSPDNRHLAVVSENGTLRVIDYLKEQLLDIYNSYFGGLTCVCWSPDGKYVLTGGQDDLVSIWSMADSAIIARCTGHTSWVTDVAFDPWRCDDRNYRFGSVGEDGKLLLWDFSVGMLHRPKAASVRQRGSISSRMPSSLQRVETQGTTATAGRFRSNSNISVTDGQLDTVDHPVEPRAKISILPAVCTKTVADDPICSLAFTEDHIITSDKSGHIRTWNRPKDHEEADDEDADVVAPSQTS
The following text describes a protein:
Function:
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPSLLLVVFILQFLLHIINTVGASTVNDLLWILYNKLPTPTSSSAQKAQKLKKEIVQLKRELGATSAQDNFSKWAKLDRQHNKAMAEFQKIDGSLRGHQTAFTSAVSTLRWLGTQGLRFVLQFWFAKSPMFWMPAGWLPFYVEWILSFPRAPLGSVSINVWGIACASMIALAAEGLAAVWVLATKRPTPIATEKKEAMAFAADQKSSGEKKEL
The following text describes a protein:
Function:
Represses the expression of YqjH which is involved in iron homeostasis under excess nickel conditions. Also represses its own expression.
Sequence:
MSHHHEGCCKHEGQPRHEGCCKGEKSEHEHCGHGHQHEHGQCCGGRHGRGGGRRQRFFGHGELRLVILDILSRDDSHGYELIKAIENLTQGNYTPSPGVIYPTLDFLQEQSLITIREEEGGKKQIALTEQGAQWLEENREQVEMIEERIKARCVGAALRQNPQMKRALDNFKAVLDLRVNQSDISDAQIKKIIAVIDRAAFDITQLD
The following text describes a protein:
Function:
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MWTILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALADIYARHEGKIVGIYMLNKRSILIRDAQLARQIMTSDFASFHDRGVYVDEDKDPLSANLFNLRGASWRNLRQKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMTTYAVDIIGSVIFGLEIDSFRNPKNEFREISSSTSRDESLLLKIHNMSMFICPPIAKLMNRLGYESRILTSLRDMMKRTIEFREEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIEKIAAQAFLFYVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLDICIMETIRKYPGLPFLNRECTEDYPVPGTNHIIAKGTPILISLFGMQRDPVYFPNPNGYDPHRFDSNNMNYDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFDAAPVLVTKEPLKLRLTKRK
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MKFINPKNLSPKRLFRKKEKSSVSRSDPLSFGSSSSSDESLHKPITAGSQTPTSVLPEVSGEWSDITVDVQCELAQAFRLIDRDNDGVVSREELEAVLTRLGARPPTPEEIALMLSEVDSDGKGCISVETIMNRVGSGSSSGSDPNPEEELREAFEVFDTDRDGRISAEELLRVFRAIGDERCTLEECKRMIAGVDKNGDGFVCFQEFSLMMDLQR
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Sequence:
MGSSIGSAGGATGATLGRPCPLPRTGALPQPLPRPPATRGAAPFGSGTSSSRILTVLPDNTMDLGLAAQLLKTCSKSTAMTFLDQNISFMVDYQFFRQIMLQKGILKIDQELTLDKSSTPIVSGFATNENAFRQSFANAMIKMASVDIVVGSAREFRKYCGSLIQQIGRVARFFRKHRL
The following text describes a protein:
Function:
Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis.
Subcellular Localization:
Nucleus. Note=Uniformly distributed in eggs, becomes localized to the nuclei during early mitotic divisions in early embryogenesis. Enters each nucleus at the beginning of mitosis, occupies a position complementary to that of condensed chromatin, and leaves each nucleus at the end of mitosis.
Sequence:
MSLQDESFPTDELFDQLNNLSSSGARNTWFAEHHKPAVFERDTAPFLEICYADPDFDADGDVANKSAKTCVSDPVGRDQEDEDDYDEDVDGDDHKLGCEKAPLGSGRSSKAVSYQDIHSAYTKRRFQHVTSKVGQYIAEIQAQDQKRRNVKFAGFQRVNSMPESLTPTLQQVYVHDGDFKVDKNCQTHSNSDSNYNSNSNNSSSSFDRLLAENESLQQKINSLRVEAKRLQGFNEYVQERLDRKTDDFVKMKCNFETLRTELSECQQKLRRQQDNSQHHFMYHIRSATSAKATQTDFLVDTIPASGNVLVTPHPLGDLTYNSSKGSIELALLSVAPSARVAQNPVQVQRAIHPQSLDFSSVSTEADGSGSGEHRVETSSRALVRRTPAPNNSETSQPSSNDSAIEVEAHEEERPSSRRQWEQQGELISPRQWGQHEGMYYFDKRNNRVIEVMGFNISQGRNQSHDTIHNQSINDSQTRLLVHSMSMSHLEAHDHFRSKRTTLGSRMLRFLGPCVRCRNGDPLNRSNVTYKDGLPAMPEEEFVDQRNQR