lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. Acts as a component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion.
Miscellaneous:
MISCELLANEOUS: Present with 2020 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MIKTRIEEVQLQFLTGNTELTHLKVSNDQLIVTTQRTIYRINLQDPAIVNHFDCPLSKELETIMNVHVSPMGSVILIRTNFGRYMLLKDGEFTQLNKIKNLDLSSLHWINETTFLMGIKKTPKLYRVELTGKDITTKLWYENKKLSGGIDGIAYWEGSLLLTIKDNILYWRDVTNMKFPLVLPDESEQFERLKHHAIKKFDSYNGLFAWVTSNGIVFGDLKEKQMEKDPASNNFGKFLSSSKVLLNFELPDYQNDKDHLIKDIVLTAFHILLLRKNTVTMVSQLNNDVVFHETIPRHQLTGSNTDSNEKFLGLVRDSVKETFWCFSNINVFEIIIENEPNSVWNLLVRDNKFDKALSLKGLTVREIESVKLSKAMYLFHTAKDFHSAAQTLGSMKDLSHFGEIALNFLQIKDYNDLNVILIKQLDNVPWKSTQVVLSSWIIWNFMKQLNDIELKINTTKPASTDEDNLLNWNLNLKEKSNELTKFLESHLEKLDNETVYQIMSKQNRQNELLIFASLINDMKFLLSFWIDQGNWYESLKILLTINNHDLVYKYSLILLLNSPEATVSTWMKIKDLDPNKLIPTILKFFTNWQNNSKLITNISEYPENYSLTYLKWCVREVPKMCNPIVYNSILYMMITDPRNDMILENDIIKFMKSNENKYDLNFQLRLSLKFKKTKTSIFLLTRLNLFEDAIDLALKNNLIDDCKVIVNDEILIEDYKLRKRLWLKIAKHLLLSMKDIDIKQLIRTILNDSNEILTIKDLLPFFNEYTTIANLKEELIKFLENHNMKMNEISEDIINSKNLKVEINTEISKFNEIYRILEPGKSCDECGKFLQIKKFIVFPCGHCFHWNCIIRVILNSNDYNLRQKTENFLKAKSKHNLNDLENIIVEKCGLCSDININKIDQPISIDETELAKWNE
The following text describes a protein:
Function:
Acts as a co-chaperone for HSP90.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSRHPEVKWAQREDKVYITVLLADTKDAKVNLAPEGVFTFSASAGQHEYDLKLELFDKVNVDESKINIGERSVFCILEKAEAKWWNKLLSGDGKTPHYVKVDWDKWADEDDDAGPAADLDMGGMDFSKFGDMGGMGGMPGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGMPDMGDFSMGDDLEDSDDEGQEAETKTGATSKEAGEEKTEAAAATSS
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection.
Sequence:
MPNYKLLYFDARALAEPIRIMFAMLNVPYEDYRVSVEEWSKLKPTTPFGQLPILQVDGEQFGQSMSITRYLARKFGLAGKTAEEEAYADSIVDQYRDFIFFFRQFTSSVFYGSDADHINKVRFEVVEPARDDFLAIINKFLAKSKSGFLVGDSLTWADIVIADNLTSLLKNGFLDFNKEKKLEEFYNKIHSIPEIKNYVATRKDSIV
The following text describes a protein:
Function:
May act as a carbohydrate transporter. Promotes tolerance to salt stress in a redox-dependent manner.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MAGAVATVSVGLAWLGLMAAAASATQFRVGGGRGWSVPDANAEPYNSWAGRMRFQIGDQLLFVYPKEMDAVVVVDQGAYDACNTSSSVAGGGGGRYDDGNTVFTFDRSGPFFFISGNEANCRAGEKLVVVVMADRGGRHAPPPSPPAVPPPVAPVPMPSPASSPPSPAPAAATPSLAPSPVATTPSPSPSVSPMAPAPAPTTSTPSSPPAPAAMAPSPSTTPGGVAQPPPPPGTDGANATTPAAPAANDRSGAAAAAPVVAGVVVTSLGAYIGYAMLAI
The following text describes a protein:
Function:
Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.
Subcellular Localization:
Secreted.
Sequence:
MLSKGLVLFGSALAASAHSLEARQSKSLDACPGYAASNVKDDGATVTADLKLAGAACDVYGKDLVDLKLLVEYQTEHRLHVKISDRAEQVFQIQESVWPRPASASVSPDSSDLEFSWTNNPFTFAVSRKENKETLFNTSAASLVFEDQYLRLRTSLPEKPSLYGIGEHTDPFQLNTTNYTRTFWNRDAYGTPPGSNLYGAHPVYIDHRGENGTHAVLLATSEGMDVKINDSAGTYLEYNTLGGIVDLYFLSGPTPKDVAVQYSALSGLPAMMPYWGFGSHQCKYGYRDVWEVAEVVANYSKAEIPLETMWTDIDYMELRRLFTLDPERYPIELVRGLVEYLHQHQQHYIVMVNSAVWRGDNDVYKDGAELEVWQKRANGSFYEGSVWPGPTVFPDWFHPNTQKYWDDKFEEFFSPETGVDIDGLWNDMNEPANFCPYPCSDPDVRQNADGRQIPGFPAGFQPGSNSTRRSLDSRDISPTPIKRFGARQASNNSADLAQHAGLPGRDLINPGYQINNAAGSISNKTMDTDIQNHDGTYHYDTHNFWGSMMSIASRNSMVKRRPTRRPLIITRSTFVGLGKYVGKWLGDNVSTWEQYRFSIAGVLNFASIFQIPMVGPDICGFAGNTTETLCARWTTLGAFYPFMRNHAGDTSISQEYYRWPKTTAAARKIIPVRYRLLDYLYTAFHRQSTTGLPVLNPLFYHYPTDKTTFAIDHQFFFGDDILVSPVLEENSTSVSIYLPNATFYDFWTGDKVQGNASYINLTNVDFDSIPLHICGGAVLPLRAESANTTTELRKQDFVLWIAPNATNQASGTLYLDDGDSINQTSTSNIVFTYDNGAFSMSGEFGYDAGVSIKNITVLGTEMSGEGWDGRGGRGCGGGTVGCLR
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Domain:
The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.
Sequence:
MIEIEKPKIETVELNEDAKYGKFVIEPLERGYGTTLGNSLRRILLSSLPGAAVTAIQIDGVLHEFSTVEGVVEDVTTIILNLKKLALKIYSEEEKTLEIDVQGEGIVTAADITHDSDVEILNPDLHIATLAKDAHFRVRLTAKRGRGYTPADANKSEDQPIGVIPIDSIYTPVSRVTYQVEKTRVGQVANYDKLTLDVWTDGSIGPKEAISLGAKILTEHLNIFVGLTDEAQNAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQELANKTEEDMMKVRNLGRKSLEEVKHKLEELGLGLRKDD
The following text describes a protein:
Function:
Transcriptional repressor involved in regulation of glucose repression. Binds to UAS-1 in the STA1 promoter.
Miscellaneous:
MISCELLANEOUS: Present with 556 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MFYPYNYSNLNVSTMPALPGISAFDGMQDEENVEISPERKYQTLLPVLTNSHVVENELKHKLNKTAFDFRYQTKSENGSEKWEPKYLITPNLQTRSVSFDNSSVQYNSDSSEKSSLSQLTCNSSIIQQPENGIVSNDAYNKMANSRYSLKTRKQRTDPRNTLSDEEDLEQRRKYICKICARGFTTSGHLARHNRIHTGEKNHCCPYKGCTQRFSRHDNCLQHYRTHLKKGQ
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Sequence:
MGESGLSVAGTPDAWTSAGSFIPPSIDRARLLSGESYAYYSPFPLASTGRSSQVTGDNHTITADFSTPSTSSSPSYFVLGVDEAGRGPVLGPMVYSAFYIPHTLHHSLLARDYSFNDSKVLTPGVRANLMRLLCTAGNPLHASCGWATKVLSARDISAGMMRPTSGAYNLNAQAMDATVEIIRGIVEERRVDIREVYIDTIGNPATYQQKLERIFPTLKITVAKKADALYPCVSAASVVAKVTRDMALEFCHEAVYGLQRYEAPSMEVATDSWGSGYPSDSKCVSWLRNHMDPIFGWGNECRFSWGTAKEMLELKGGTRVDWPVEEEGAAPIKAFLLTTARNAKRTEQDELREWFGRRSTEVL
The following text describes a protein:
Function:
Transcriptional activator required for the expression of glycolytic genes. Enhances the CT box-dependent transcriptional activation of a RAP1-GCR1 complex. Required for GCR1 phosphorylation.
Subcellular Localization:
Nucleus.
Sequence:
MHHQTKLDVFIIRAYNLLSNESVISGASLQSVTNSPQTTTNTPSGMVNGAVGTGIANPTGLMGSDSTPNIDEIITSTGSNALTKTNSDSANGTPNGNSSSTSAISNASNPATTGNNASSSATSNGIYTQAQYSQLFAKISKLYNATLSSGSIDDRSTSPKSAIELYQRFQQMIKELELSFDASPYAKYFRRLDGRLWQIKTDSELENDELWRLVSMSIFTVFDPQTGQILTQGRRKGNSLNTSTKGSPSDLQGINNGNNNGNNGNIGNGSNIKNYGNKNMPNNRTKKRGTRVAKNAKNGKNNKNSNKERNGITDTSAFSNTTISNPGTNMLFDPSLSQQLQKRLQTLSQDVNSRSLTGYYTQPTSPGSGGFEFGLSHADLNPNASSNTMGYNTMSNNGSHSWKRRSLGSLDVNTLDDEAVEELLQLTNTSKRQRPMTTAAEGALINDGPDTNLNANNTQMKVDLNPSNSMGPIDTEAVIRPLKEAYDAIISEKGQRIVQLERELELQRQETQWLRKMLIEDMGCVRSMLRDLQR
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MQETWLPSAEGKETLGERQAESRPRLGGLGSAPEVKSEPDDCCAHEVDHRDVKAVLEHRDESVAVRGHKEEELDDLDIVRLTEQDTKPQPTGEFWEAGRPQPEQRGGRSPAGPGPEGTGDRSLGEGQGREPDRLGSPPQPPAAAAAAVTPGGKPFACGQCGKSFAQACNLRSHQLVHTGQKPFACGQCGKSFAQACNLRSHQLVHTGEKPFACGQCGKSFSQACNLKRHQHAHSRQKPFGCGQCGRGFTQPGALRRHLCTHTGEKPYRCASCGRGFSRACYLQNHQHVHTGERPHACGQCGKRFSHASNLKKHLHTHTGERPFACGQCGKGFRHLYRLKRHQPIHAGEKRFVCGQCGRGFRTPGGLQSHQLSHAAQKPFGCPQCGKGFSLASSLKVHALIHTGEKRFRCAQCGKGFTQSGGLKTHQVVHTGERPFSCAQCGKSFNQSSNLRKHQRLHAGQAPQKPEERAEPGEGGARGVKLDPE
The following text describes a protein:
Function:
Antimicrobial peptide. Active against fungal species B.cinerea (IC(50)=5.8 uM) and A.niger (IC(50)=5.6 uM) but not against F.oxysporum, F.graminearum, B.sorokinina and P.debaryanum at concentrations below 10 uM. Active against bacterial species P.syringae, B.subtilis and X.campestris.
Sequence:
VAKCTEESGGKYFVFCCYKPTRICYMNEQKCESTCIGK
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MRTSIPQDKINISPTSIIDRVEKVVYGDYTPKQWGQYVTQLLPKKTCGISWTSKKFALHCETCQNDINSCVCLKCFLNGKHEGHQVSFRYSSNASCDCGDKQLWKEEGFCPDHPGCSEHLEKTDIPQDLYQKYELVFQALIKVLPLSFDNNETNAAERIVNFMLLHTSYGDAIRRCFTLAFSRYADIPRIFDNIHNIGKAAQNFSTLLSNVSNDPVFRRDIAPRLIFCLPIFVNRSMIVNLEAKGGKKYKGVEEIEEFSKGIFHWFSTSNLDLLFRKGFNWPQQAIAILRALCILSVKAPNMNTVKNTQIADILGQFDSCIVPEEDPDAIKNIALQIAERLVQTAGIHPFTRQMNIKVDDPNQIQSIVHNFEFTVGGFMTSLNSIPKAFSPKVFDVFAEYIKNKQPEYGNVLDKSTEISQATALYILLEIELRLSNDIPKWLDHMATIAGITRTELCSRIACLPIKHIAASRFAHFNKYVRNDDETYISLISLSYKYNLQYRFAPLFALVQICAEYTEDINSFMKYMAITYGVLSDNEEERSLSLSIFVLDSLFLVTDRSCFMNDSGDLLDSTIVALLKSGDKSYSDIQSTLPNIKNVATQIPLHINNLTKTITTGSKSLLTLKDSHPWTLGVPWVKTNYNYSILNEFSAKNKEIPFSFPLQDDDRKGLLRILSTPAVKYSAIYLTSTQNTADGQLLNGYLNVLCQLEGYNTTIVPSKEAIRPDINNFDQNLTQLIINTYDLGEKTMSLTDLAKENPTTAALLAKFGVQIGNTLDKVAQIKKNKERARAARERAIQSLNINNNLFNDMEDVDDEADLKQVCSICQEEGTEPLNLPVFVHTSLVPSIIEKSLRTFNTDHSIKYESYKVCTACQHICHSDCVMRQESGCFYCSLCRGLRNDMIPLCKYTNFDIDEVDLDEPINGPQDSILNYTSSVISQLISSSVVNLEARHRMNPGALDSPANSMLYKSLFAIAWKKAHMPSDDLITFNNNKLCNLVKQLSMQDKPGLEYTRIVKSICEEITDKEEIYPFMRRAAILQALIFSLNKDQFFEWDEYLEYENLCQKFCIEPVKDVDISVIPFKLINLPQCPVELYRPPFDEDTMPYESEVYYCLLDKHLLIRQNDQLQQTLNTRYKGAVIPVIQLTNEKALSIKYVSIELNKFFEGPRAYYSLLGQPVIGLESSDILSLSQDKVTEIEDDLLSGNFTRI
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase V involved in RNA-directed DNA methylation-dependent (RdDM) silencing of endogenous repeated sequences, including transposable elements.
Subcellular Localization:
Nucleus.
Sequence:
MEETMAEEGCCENVESTFDDGTNCISKTEDTGGIESKRFYLARTTAFEMLRDRGYEVNEAELSLTLSEFRSVFGEKPELERLRICVPLRSDPKKKILVVFMGTEPITVKSVRALHIQISNNVGLHAMILVLQSKMNHFAQKALTTFPFTVETFPIEDLLVNITKHIQQPKIEILNKEEKEQLLRKHALEDKQLPYLQEKDSFVRYYGLKKKQVVKITYSKEPVGDFVTYRCII
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MANARALDKRRKSIRNIRKITRTMELIATARYKKAMDRAAAATAYTEQITKIVSRLADAGLDVQHPLLEQREKINTTRVLVLASNRGLCGGYNASILRTALPRIKSLRESIPNVIVDASGKRGVNGLKFRGIETEQRFLQFEDQPAYDDVEKIAEGYLAEYITGKIDRLDVVYTKFISTSKQEAVIETLLPLGSLGDESDSASDGSDDTNAEYEFLPSAESILEEVVPTSFKVKLFKCFLDAAVSEQVARMIAMKGATESAGDMIKQLSMTYNRARQSQITGEIMEIIGGVEALEG
The following text describes a protein:
Function:
Mediates microtubule-dependent, anterograde transport connecting the Golgi network, endosomes, autophagosomes, lysosomes and plasma membrane, and participates in several cellular processes such as regulation of lysosomal pH, lysosome protein degradation, receptor-mediated endocytosis, autophagy, transport of proteins and lipids from the TGN, apoptosis and synaptic transmission. Facilitates the proteins transport from trans-Golgi network (TGN)-to other membrane compartments such as transport of microdomain-associated proteins to the plasma membrane, IGF2R transport to the lysosome where it regulates the CTSD release leading to regulation of CTSD maturation and thereby APP intracellular processing (By similarity). Moreover regulates CTSD activity in response to osmotic stress (By similarity). Also binds galactosylceramide and transports it from the trans Golgi to the rafts, which may have immediate and downstream effects on cell survival by modulating ceramide synthesis. At the plasma membrane, regulates actin-dependent events including filopodia formation, cell migration, and pinocytosis through ARF1-CDC42 pathway and also the cytoskeleton organization through interaction with MYH10 and fodrin leading to the regulation of the plasma membrane association of Na+, K+ ATPase complex. Regulates synaptic transmission in the amygdala, hippocampus, and cerebellum through regulation of synaptic vesicles density and their proximity to active zones leading to modulation of short-term plasticity and age-dependent anxious behavior, learning and memory. Regulates autophagic vacuoles (AVs) maturation by modulating the trafficking between endocytic and autophagolysosomal/lysosomal compartments, which involves vesicle fusion leading to regulation of degradation process. Also participates in cellular homeostasis of compounds such as, water, ions, amino acids, proteins and lipids in several tissue namely in brain and kidney through regulation of their transport and synthesis (By similarity).
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Late endosome. Lysosome.
Sequence:
MGGCAGSRRRLSDSEGEETVPEPRLPLLDHQGAHWKNAVGFWLLGLCNNFSYVVMLSAAHDILSHERTSGNQSHVDPGPAPIPHNSSSRFDCNSVSTAAVLLADILPTLVIKLLAPLGLHLLPYSPRVLVSGICAAGSFVLVAFSHSVGTSLCGVVLASISSGLGEVTFLSLTAFYPRAVISWWSSGTGGAGLLGALSYLGLTQAGLSPQQTLLSMLGIPALLLASYFLLLTSPEAQDPGGEEEAESSARQPLIRTEAPESKPGSSSSLSLRERWTVFKGLLWYIVPLVVVYFAEYFINQGLFELLFFRNTSLSHAQQYRWYQMLYQAGVFASRSSLRCCHIRFTWALALLQCLNLAFLLADVWFGFLLSIYFVFLIILYEGLLGGAAYVNTFHNIALETSDEHREFAMATTCISDTLGISLSGLLALPLHDFLCQLS
The following text describes a protein:
Function:
Acts as a nucleation-promoting factor by activating the Arp2/3 complex to induce actin polymerization.
Sequence:
MTTQIYQVPVVSNGLRETESILQIVDSLEKLEKVFNDMYSTISARVSHEKSRIDNVANRLNNAQHKVNQIVGSKQAITVFSSAKYPADKKWGDYVPIYSGKHKLPFKPSHYHGLNSEDSPIKKRPEDSYLDVNDLVFIEKSIDTTSKEVEVKEGLGRIPAQIPSVSNLLLFNTQENPYKKYSNTLDNLSGGDGGEDDYTIFGDQLSKKKRLGDAPVTVKDGDSRIDAENVKIGYEPGTFEIPVYNFPSILPLPNVAENITWAAESQSIAPSQKATLNLLPTYDNSNSGSAPVNQSSGGDNNVNNNNNNNNSNNSTGIMQPPQPTNAPPPPPPPPQSANAPPPPPPPPVSAPPPFNPPSVNSNNDDDDDDDDDNGGGGGPGGAIGDLLADIRRGHKNRLKKADVGGDNGDGEDNKPPPVSDGGGGLMGDLFKKLALRRQSIATTKSTKKQSKSKKEDTDDQDGESDTDSSEWE
The following text describes a protein:
Function:
CAHS proteins are cytosolic heat soluble proteins that seem to contribute to the anhydrobiosis in tardigrades, but their specific mechanisms are yet to be identified. It is possible that protection during anhydrobiosis might occur via the stabilization of vitrifying small molecules such as sugars, but not via the direct glass transition of CAHS proteins themselves (Probable).
Miscellaneous:
MISCELLANEOUS: Trehalose, a disaccharide essential for several organisms to survive drying, is detected at low levels or not at all in some tardigrade species, indicating that tardigrades possess potentially novel mechanisms for surviving desiccation involving tardigrade-specific intrinsically disordered proteins (TDPs).
Subcellular Localization:
Cytoplasm.
Domain:
CAHS proteins contain 2 repeats of 19-mer peptides designated as CAHS-motifs that comprise each two octapeptides connected by a tripeptide (By similarity).
Sequence:
MSNYQQESSYQYSDRSNNGQQQEQQEKKEVEHSSYTHTDVKVNMPNLIAPFISSSAGLAQELVGEGFQASVSRITGASGELTVIDTEAETEEARRDLEAKAREQELLSRQFEKELERKTEAYRKQQEVETEKIRKELEKQHLRDVEFRKELMEQTIENQKRQIDLEARYAKKELERERNKVKRVLERSKFHTDIQVNMEAAAGSTHSGSSSVAVSESEKFQTNN
The following text describes a protein:
Function:
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MQSNQWGQYPYSQQQQPSFLNSQPTGFAGAGLQPMQTGFPQQQRPQQTGIAGAQPGQNYAFLNQPPSSNFRGNGIAPQMTGFPGGTGMVSQQTGMMPQQTGFNASANAGRMMPQQTGFQGGMMSQPTGMMSQSTGMGLTPQQTGWQGGAGLMSQPTGIGRLQAQPTGMPHDPRLQTMMQSFMPSNMSQPFSSGVPQFAQSSQPLQQTFQSLLQNPSVNTPKIPWTLSRQEKKDYDQIFRAWDTKGDGFISGDMARNVFGQSGLSQDDLMKIWNLSDVDNRGKLNLPEFHVAMGLIYRALNGNQIPDKLPEELVPASMRDIDSTVNFMKDLLKHESISRPGTASPAYSTPASASKDALLYKHSDEVPSTYKPSSRHLDRKSVRYGGEDPDAGLKDIRRKLENTSSLLEKSAEKSAEDEELEEEIETLQYRVKRIQEDIEYTSKGRRTAEKDEERRKLERELLYLMHEKLPELERRQERRREEKAMEERAGVRRRDERNKTHGRFDDRDRDRDEYERYRGTYDRERDRSRERDRYDYDRDRRDRSRDRSRDRYDRYDKYDRDRRDDRDRYDRPRSPTGVRSPPPAPPPPSASATSSSAPPPPPAPTSSSSVPSTKNMTPEERKAYIREQAQRRIQERLKALGVSSEDKEEEVDTSVQDRLEKERKEAEEKSRKAEEAQKERDEARKRRLAEAGGAAAEPKSEEKPAEPAAPSLKSAMKKPAAPPPAPTPRSKAAPVPPPSRAHPAPAPPAAPTPPTPQPPTPKPDEDDPEELELRRREEAAAKAKAERRARLEALQKEEEEERRQEEALLAARKNRSLGASPVPPAAETPKKEASSSAAPSPAPPAPPAPPAPPAPPAPPAESAPSYNPFRKPGGAPGATPSPAAPAGGFNPFFKPPAAASVSPSPAAESPALAAPPPPAPPPPPADPAFQPPRGPRSPPSEPEWEDIAEKQVDESDSSDDEYTTSRAGRQGLAQALFGNIMGGSSPSTSRPGSAAPQAPKEPPKALANVGGGNPEQGRGALLSAIQGGARLKKAQTVDKSGPPDIGRVIGDAAPPSHIRETPREYAPPSPPAAAPGPVEERAPSPAPPSEDSFISGNPNRQSIDWYAGLAADASHPAASVGETSMLEPPQEEEEEKEQHGYEQIEKPRVQIEGEDDLNEFDFATTIRVRALYEFVGTRDVDLSFKEDVVIEAHPAKDESSPWWYGTVVKDGSKGWFPKNYVEHIQAVRAKALYSYAAGDPDQLPFAEGDILEVVDRSENDWWKVENTGIIFLVPAAYLEIIDG
The following text describes a protein:
Function:
Transcription factor that is involved in protection against oxidative stress. Binds to promoter regions of the gliotoxin (GT) biosynthetic genes gliZ, gliF, gliT, gliM, gliA and gtmA. Two related but different DNA motifs (5'-TCGG-3' and 5'-CGGNCGG-3') are specifically enriched among rglT binding sites in GT-inducing conditions. Also indirectly regulates the expression of gliP, gliG, gliH and gliN. Plays a key role in resistance against exogenously-added GT and GT biosynthesis, mainly through the direct regulation of gliT. Furthermore, rglT is important for virulence in chemotherapeutic mice with invasive pulmonary aspergillosis (IPA).
Subcellular Localization:
Nucleus.
Sequence:
MQFDSLPLPPSSSHDTTSVPPLKRHAACDECRKRKLKCSGEATGCSRCLKQSLPCHYSLQKPMGRPPKKRPREDNDASVYEITDNGMWADIDDGGILTEEAGAEATAASDALRLCPPVYTAPMRMPQAFPNLLSTDDSHNHLWQLESGRSLDPIPATTGPWPDFSSVTAATSSPFTLPSSLTLIDSPSVSSPSSDGGNSSQCTCLSYLYLCLSHLSSLAPFPISQHTLCSLFIAAKTARAVIRCEVCPTSFALGMQNVMFTGTLLNVIADAWLRVSQADAEELGKLAAPPAYVASVTQNSPNPAEAWKDWLRQTVRSAITGGPADPAGQVKCSDSPTLLSLIEEMEARQHRWHRTRTVESPNEPGSCSPVSHEDHREEDMLCFRVIRSARDVIAKFEFAPHEYPEGVVPV
The following text describes a protein:
Function:
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The RxxxRR motif forms an adapter helix that bridges the nucleosome and ubiquitin.
Sequence:
MSRSSAGFADFFPTAPSVIQQKRYQATRERQRSRPHLSREHADEEQIVTGSRTSGETVNGNSPQNLGQELRSDLNKSRKEVAEDGSASHGEANTPANNTSGPGTGSSNDTRLDTLTPLTNTESSPQNNPSPSQAKAPNGDEPDGFRQARANVSNSTMTPLHTPPTPTTHSLSQRVAIVKGSKLVHDPDRAPSKDKRKRPCYVDIVSDEQEGRLSDPRLSIQNYTRGAGCRQKTKYRPAPYVLRHWPYDPASTVGPGPPVQIVVTGFDPLTPLAPISTLFSSFGEIAEINNRTDPDTGRFLGICSVKYKDSASFHGSGPVSASLAAKNAFHECKKGQRIGNNRIKVEYDRDGQTSEKLASRAIAAQRIDSKIDMPVVGEPKSEAQVNKNEPPPTAPKGPSGRSFMRPSAVIPEGPRASFQKPAIPSLIEETPILNQIKRDPYIFIAHCYVPVLSSTLPHLKKRLKAFNWKDIRCDRTGYYIIFENSRRGEEETERCYKFCHMKLLFTYIMNMESQPYGNPHYERSPSPERMKQEQRQKAETERLKKEAELDIEEEKKQRALDLDPCTEVLAIVIKDLRDKLLEDVKSRIAAPALYDYLDPERHASRRKQLGIPDPEGIKRPMFRLDFDSRDSTPDPHAKFLNKRHPSGVSGLNILSALPRIRKAHRLDRTDVAFLDERRKQPLRRRNVRPLYHRLQQLHDAEDSDEEQHTPLSRDTDDQDSRPPSRIGSETESEDADEDAAEALDNSTERLDNEDRHSEIGDLEAAVQDYSPSRKRKRTSESPSHRKKQKESDDFSAVGEGTRTDDIPQVLDGVHKGTVSQGLSDSADESSRLDHNKVLLEELVEDIKTTHSEEPGIKTHHVQVRQSAENMVEGAEYGEAARHEVEWRVSNDEPRPIVDDDDSVVMDLDGWQDVVKDEEDLQFLRNILEKQPMSVIGNLSAWAWRQKEIKALNRPGDVGPTRQAASIEGYYVPNITGAARTEGRKRILESEKSKYLPHRIKVQKAREEREAKAKSDPQNAAAEAARIAAAKTISKSTSRSTRVNNRRLIADINAQKQALPSQGGDSDVLRFNQLKKRKKPVRFARSAIHNWGLYAEVNISANEMIIEYVGEKVRQQVADMRERRYLKSGIGSSYLFRIDENTVIDATKRGGIARFINHSCTPNCTAKIIKVDGSKRIVIYALRDIERDEELTYDYKFEREWDSDDRIPCLCGSAGCKGFLN
The following text describes a protein:
Function:
Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat (By similarity).
Subcellular Localization:
[Corazonin]: Secreted; [Corazonin precursor-related peptide]: Secreted.
Sequence:
MKHVFSTSLIVSLFVIFTDAQTFQYSRGWTNGKRSSPEQTAPSRTLLPHIPLGMDKPDEECRLLIQRFLKSPCDVRLANAIVNRNKDLLRDMADDVNDGTALLYDPVPMVDTAASEDVRFKRGTPDRRLLNDGMHRL
The following text describes a protein:
Function:
Involved in the breakdown of putrescine via hydrolysis of the gamma-glutamyl linkage of gamma-glutamyl-gamma-aminobutyrate.
Sequence:
MENIMNNPVIGVVMCRNRLKGHATQTLQEKYLNAIIHAGGLPIALPHALAEPSLLEQLLPKLDGIYLPGSPSNVQPHLYGENGDEPDADPGRDLLSMAIINAALERRIPIFAICRGLQELVVATGGSLHRKLCEQPELLEHREDPELPVEQQYAPSHEVQVEEGGLLSALLPECSNFWVNSLHGQGAKVVSPRLRVEARSPDGLVEAVSVINHPFALGVQWHPEWNSSEYALSRILFEGFITACQHHIAEKQRL
The following text describes a protein:
Function:
Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation. Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter. Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes. Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors.
Sequence:
MMKRALLLCLSLFCIQFALSVVVKPNGDTEEEDPCSNVFCHAGQECVAAKGKASCECLSECPDHIKPVCGSDGVTYPNHCELHRIACVHTKKITIRSKGPCEEIPSSAPTGKVNMSKPVVCYERDRDQMRGRMIEWMQMQEESLANAAGYQRVLKRFFDMVDKNKDGKLNLKELTELVKYNQTVAEIREADEFINPVLQGLCSDALISITDDDEDTELTFKEFRKCLDPDFKPPMKNCELEGEQYKDGAEIPTDCNSCVCACGRWVCTALDCNPSSNHVKASLVLQGEQAKEKLEREVLAENPEQKRVLLLHKPSKHGMHRMHHRHERTRKSGKSG
The following text describes a protein:
Function:
Polymerase responsible for protein-primed viral DNA replication by strand displacement with high processivity and fidelity. To start replication, the DNA polymerase forms a heterodimer with a free primer terminal protein (TP), recognizes the replication origins at both 5' ends of the linear chromosome, and initiates replication using as primer the OH-group of Ser-232 of the TP. This polymerase possesses three enzymatic activities: DNA synthesis (polymerase), primer terminal protein (TP) deoxynucleotidylation, which is the formation of a covalent linkage (phosphoester) between the hydroxyl group of a specific serine residue in TP and 5'-dAMP, a reaction directed by the second T at the 3' end, and 3' to 5' exonuclease activity. Exonuclease activity has a proofreading purpose. DNA polymerase edits the polymerization errors using an intramolecular pathway as the primer terminus travels from one active site to the other without dissociation from the DNA. DNA polymerization catalyzed by the DNA polymerase is a highly accurate process, but the protein-primed initiation is a quite inaccurate reaction. Since the polymerase initiates the replication on the second thymine, the TP-dAMP initiation product translocates backwards to recover the template information of the first nucleotide (sliding back-mechanism).
Miscellaneous:
MISCELLANEOUS: This DNA polymerase requires a protein as a primer.
Domain:
The N-terminus contains the 3'-5' exonuclease activity and strand displacement ability. The conserved motif YxGG/A located between the 3'-5' exonuclease and polymerization domains is important for DNA-binding, coordination between DNA synthesis and degradation and for the formation of a stable complex between TP and the DNA polymerase. The C-terminus is involved in the protein-primed initiation, DNA polymerization and pyrophosphorolytic activities. The YCDTD motif is essential for the pyrophosphorolytic activity. The TPR2 region is necessary for the strand displacement coupled to DNA synthesis and probably also for allowing the TP priming domain to move out from the polymerase during transition from initiation to elongation.
Sequence:
MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVLKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSLYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWARYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKEVDGKLVEGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK