lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MHPISACRRASPLSTPRFQDIFVDASLKADRAGIGVNYHTRREFEKYSLVRRPDRRPDSNHAELAAIFVALLHSRGSRKTRIFTDSQTSIDLIREGTLDPRFAVLVGCSRWLLAESEETLLFKVKGHSGVPGNEVAHRLAAMGRRDGAIVLPDYLIGRAECRDRLIPALIDECARLNQWQIESFKRTQAGASSQAEIMSSSSVCTKKRTMPTISGEVPSSEAASSRSSLTRLLTSSASTPTSFLESESNLLGLMLASLSYAADNMTFDFKPHFHKAFQLAEEIGSGSFGRTHVAFARKMGDGDGKRVAVKVIPKRRMSSQVEIDDVVREVEILRVLQRNENVVEFIDAYEDAMNVYIIMELCSGGDLSDRILDAGGRCSEESAVPLVWQILSAVAYMHRRGVIHRDIKPENFLFASDDENSILKAIDFGLSDYCREGDVLSDIVGSPYFVAPEVLKKAYDLKADEWSIGVMTYIMLVGARPFYGRTQSEVFRSVLDEKPNMEEVEITAEARDFIEKLLTRDVRGRLTAAQALTHPWMSEVRNR
The following text describes a protein:
Function:
Involved in ethylene-dependent salt stress responses by reducing reactive oxygen species (ROS) accumulation.
Sequence:
MNQEAASNLGLDLKLNISPSLDSSLLTESSSSSLCSEEAEGGGGEAKSMVVVGCPNCIMYIITSLENDPRCPRCNSHVLLDFLTGNHSKKSTS
The following text describes a protein:
Function:
Involved in the degradation of long-chain fatty acids.
Sequence:
MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDAGVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIHGAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIGSGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVYSYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Subcellular Localization:
Nucleus.
Sequence:
MEAQDYFVGGYYGAGENQFSPEKRHGDQKPPCEPFAIDDLLDFSNADVIMSDGFFDNNVAGNSTDSSNVTAVDSCNSSGSGGDNRFGGTIVPYGFSGDVQLTGELCVPYDDMAELEWLSNFVEDSYSAEEELKTLQLLSGAGAVKPQTPESSSSTDTLPSFSTDETARNASFLRPETPLPGKARSKRSRAAPGDWSTRLLHLPDAPPKNYPIVKKREDPNVECSGRKCLHCGTDKTPQWRTGPMGPKTLCNACGVRFKSGRLVPEYRPAASPTFVSAKHSNSHRKVLELRRQKEMQRSSQHHHHHQHQQLLSHSSIFGVSSNGGDDFINYHHHCGPEFRHVI
The following text describes a protein:
Function:
Splicing factor that controls alternative splicing of the developmental regulator ABI3. Reduces splicing of a cryptic intron in ABI3, leading to a decreased in ABI3-beta transcript. Regulates the splicing of the receptor-like kinase SNC4/LRKL-2.6.
Subcellular Localization:
Nucleus.
Sequence:
MDPSRYGRQQEWDNNSAPEGYGTQHDPNHRFGVSYDDGYPDERLMRDDVYNYPPGHNTLGDLPQSRKRNYEENYPSELRRQEKPYIDSNYAADYYHDSEAGSRNGHYRDHEHERSSRYDGCDDYSCNDNNYRSKNYHHSRDDGREKDYDYTRRSYDSEYERASVRDGSRKSRDPQDRERNSRDREWDSRDREWDKRCYSRERDESPHKRYEKSRSRSTGRGEFSRSRSPRGRSHGRSYREDSYEGDHWNESERRREYEDRHNQDHFSATPSATVVVKGLSMKSTEEDLYQILAEWGPLHHVRVIREQNSGISRGFAFIDFPTVDAARTMMDRIEHDGIVLDGRKLMFHYSQPTGRAGVSRRQEHASRRSYGGSRNMIVPTDWICTICGCINFARRTSCFQCNEPKTKDSPSADVGLSNSAAGKRISETGPTHVLVVRGLDEDADEEMLRYEFSKHAPIKDLRLVRDKFTHVSRGFAFVHFYSVEDATKALEATNRTALERNGKILRVAYAKSVHGSGTGISAPSHSNNLAAAAIEAATFSQQYDGVGWAPKEYNTGEKQNTGGQAQGVGEIESQKGTSAPQSGYVWDEASGYYYDAASGYYYDGNSGLYYDSNSGLWYSYDQQTQQYVPCPDQNNESKVTENQPDSAKKEKSSQQKVIISAATTPNVEKVLSLPDAVQAAAAAAIASEKREKERVKEIKLASKTSLLASKKKMSNVLTMWKQRSHETQIQRPSPSLGDNPPTVSAEARSSFSTGQSMGKLKSDVIIAKERSTSNHGVSALTTAESSSSSTTGGTLMGVMRGSFGGTLGGASSSASVQMPPILPSASPASVSVSGSGRRRFSETPTAGPTHREQPQTSYRDRAAERRNLYGSSTSSGNDVIDSSEDLMGLRKGSSDPTPFPPGVGGRGITTSTEVSSFDVITEERAIDESNVGNRMLRNMGWHEGSGLGKDGSGMKEPVQAQGVDRRAGLGSQQKKVDAEFEVQPGDTYRTLLHKKALARFRDMSDNN
The following text describes a protein:
Function:
Transfers the UMP unit from UDP-glucose (UDP-Glc) to Gal1P. Can also transfer the UMP unit to GlcNAc1P and GalNAc1P. Involved in the general galactose metabolism, and also involved in the lacto-N-biose I/galacto-N-biose (LNB/GNB) degradation pathway, which is important for host intestinal colonization by bifidobacteria.
Subcellular Localization:
Cytoplasm.
Sequence:
MNDQLTEVYASIDALIDYALAHLDLDPRNADWTRNQIFALFRLDSYPGPKTTTSAASVSDVVQDIVGSRSQAPYGEKTPDPLLAAFRAAATTAGLFKPEEGPAYADTIMGILSANPADLDDRFLLVEHRDGGMAAMQWFYDYCVANNYVKRAQLDRNPRFDSHGLTVTINLAKPEFKNMKKAAAGNAVAGGYPKCTICHENEGFAGRDKRTLRTLPVTLGGESWFWQFSPYGYFDQHGICVNTDHTPMHVDRDTFGHLLDFVDRFPGYFLGCNAALPRIGGSVLAHDHYQGGGELLPMHKAATWAAFTLADYPDAVVEILDWPGTAVRVVSKSRQSIIDVSDIIREAWVGYDDAANGIASHDADGNRQSALSPSAIITERGYEMSLIFRNNAISDEYPEGIFHAHPEYWPVKQEPIGLIEAQGLFILPGRLVDQLGIVEEALAEGRDLPDEVSEFSLEWGELAETLAGNHDREAIRQAVHDELGSVCYRILGNTAVFKQKATTQTFLESLGFAAR
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MERQPKRFVGASVRNVDEIYKRIKPLFREISSCSRCEERRSASKGTPKAYCVTVDVERCFDTIRPRKLYQVLKKAIQEDEYLIRKHWVGHQVAPISDSDESLPSSSFFFKLERPAYPSGELLGFEELAAQSKKENAMFVDGVLYDYLTKAKALELLKEHLSTNVVQVDGRDYVQRCGIPQGSVLSTTLCNMYYAHFERRVLGKRLPELYVNYEKLSSSLLQASIPFNETKAAQEFFVTKVVSAIRQRWHALYFDPELLSEDTIRVNLFQMQIVAAHRFTILIEMLPFVNRDMHFFHECIHRILKKMTKGIHRSLELAAQPSSGLSLSSYHAQKHQVRKYSNLSTYILPLTCLFVPLVQVWTIGLRAFQLMIQAKRDQAKTSNAQRKQQCNWVDWQKLLDAIQSEQKEFKQQEKKTRSTGPAFDFAWLMSDRRNASMLKRCLGVGSVDRS
The following text describes a protein:
Function:
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure.
Sequence:
MGITSPPTEDSGGGGGELSEPMPFKFVAWAGSADASFWHRLADFKLDTQKLTEVPISISGFFAPCNQPHAPSYLQLMMESLPLDTGASNEPTEVPYNRNRLPVPGMLYNTNTLESYNALDKPALLRATADQIWDDIKSGRAEEDTSLLSRFLVVSYADLKKWTFTYRFAFPGLRMSPQATAAACQAARDFFSKDEIAGVLAACTEWRALPSGASLTSFLINITPDGSIKSQSLKEWHTAQQEGGKIVLTFYDPSNLPANPGWPLRNLLALASVRWGVSRLQVLCYRENRSGQLDLEHSPVLDIILPAKIEWMEPVGWELNARGGKGSKFVDLGQSMDPLKLAESAADLNLKLMRWRLLPSLDLPRMASTKCLLLGAGTLGCQVARTLMAWGMRHITLVDYGRVAFSNPLRQSLFTHEDSLHNGKPKAEAAAENLKRIFPGVNAVGVQMSIPMPGHSVGKNEIAGVVEDCRRLKELVDTHDVVFLLTDTRESRWLPTLLCADANKVAINAALGFDTYLVMRHGAAPSLDSNSSSDGQPRLGCYFCNDVVAPLDSTANRTLDQQCTVTRPGLAPIAASLAVELAVALLHHPLGVSAPGDQATSLTDNTEHPLGIMPHQVRGFIAHYAQLVVTGQAFDKCTACSASVVREFREKGVEFILEVLNRPNYLEDLTGLTELLRITDDEPLVWDDDADF
The following text describes a protein:
Function:
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
Sequence:
MLKYPDYISKLISFLKKLPGIGFKSAEKIAFELLEWDPSQIEAMAQALQEFSTSHATCSNCFCLKISQTSPCNFCSESRDSSSLCIVATPKDVFALEKSKIFKGHYFVLGNLLSPITGKHLSLEKLAILKQRIEACSPKEMIIALDATLEGDATALFLKQEFSYLPIKISRLALGMPVGLSFDFVDANTLARAFSGRNCF
The following text describes a protein:
Function:
Envelope glycoprotein that forms spikes at the surface of the virion envelope. Participates in viral entry through an RGD motif that binds ITGAV-ITGB3. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
Subcellular Localization:
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Sequence:
MTPRSRLATLGTVILLVCFCAGAAHSRGDTFQTSSSPTPPGSSSKAPTKPGEEASGPKSVDFYQFRVCSASITGELFRFNLEQTCPDTKDKYHQEGILLVYKKNIVPHIFKVRRYRKIATSVTVYRGLTESAITNKYELPRPVPLYEISHMDSTYQCFSSMKVNVNGVENTFTDRDDVNTTVFLQPVEGLTDNIQRYFSQPVIYAEPGWFPGIYRVRTTVNCEIVDMIARSAEPYNYFVTSLGDTVEVSPFCYNESSCSTTPSNKNGLSVQVVLNHTVVTYSDRGTSPTPQNRIFVETGAYTLSWASESKTTAVCPLALWKTFPRSIQTTHEDSFHFVANEITATFTAPLTPVANFTDTYSCLTSDINTTLNASKAKLASTHVPNGTVQYFHTTGGLYLVWQPMSAINLTHAQGDSGNPTSSPPPSASPMTTSASRRKRRSASTAAAGGGGSTDNLSYTQLQFAYDKLRDGINQVLEELSRAWCREQVRDNLMWYELSKINPTSVMTAIYGRPVSAKFVGDAISVTECINVDQSSVNIHKSLRTNSKDVCYARPLVTFKFLNSSNLFTGQLGARNEIILTNNQVETCKDTCEHYFITRNETLVYKDYAYLRTINTTDISTLNTFIALNLSFIQNIDFKAIELYSSAEKRLASSVFDLETMFREYNYYTHRLAGLREDLDNTIDMNKERFVRDLSEIVADLGGIGKTVVNVASSVVTLCGSLVTGFINFIKHPLGGMLMIIIVIAIILIIFMLSRRTNTIAQAPVKMIYPDVDRRAPPSGGAPTREEIKNILLGMHQLQQEERQKADDLKKSTPSVFQRTANGLRQRLRGYKPLTQSLDISPETGE
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFNSFSKSSLEFILTETQCTTMEQFSASSMSRHHAPYDRRFGSIYPLFQLLGFTPVPLHGQALTSLRTLTIVFVSFYTTGEIIVLSYSLIKPEAVFFLSDATGTFADAIQFVIPLAVPLVTLTLSLLKRSTQKRIALLMDQIDGSIEAHGAAPGCLERFNHQLADDIFSTMFVFNVIPAVSEFFIISRISGNPVWHRNWLLKVWFFILIRLGDSFFLVHVLYLRNRYRVLNNELQQTASTVGRAISPEAIHRRLVHLKAMQNLLKDLTGEVSDRFGWQLFAVITMLFICTTIDGYWMYASLHYDGNLYKVESFLCGISPVLMFFVLFNTCQKCVDEGEITFYYLHSVLNRVLPQTTITLIENFSKQLDNEQINFSAANFFDIRLSSLTTIFGSITSYLVIYINFIPKTDTFNDYNKEHNLVTT
The following text describes a protein:
Function:
Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDKLTLTPLERALQCARFALDKKALDVKVLEIGRISSIADYLVLATGRSDKQAQAIADSVKKGLKKYGKVIDMEGLREGNWIVIDYGDVIVHIFREELRSYYDLDGLWSAAGQVAIPAEYLWEGKEGGGE
The following text describes a protein:
Function:
Acts at an early step in the ethylene signaling pathway. Positively regulates ETR1, leading to the negative regulation of ethylene responses.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MSRGRGVPMMDLKRSYDVEDRVVSVSIPSIIEADEADLWPLPEIDTKKSKFPCCIVWTPLPVVSWLAPFIGHIGLCREDGVILDFAGSNFINVDDFAFGPPARYLQLDRTKCCLPPNMGGHTCKYGFKHTDFGTARTWDNALSSSTRSFEHKTYNIFTCNCHSFVANCLNRLCYGGSMEWNMVNVAILLMIKGKWINGSSVVRSFLPCAVVTSLGVVLVGWPFLIGLSSFSLLLFAWFIIATYCFKNIIT
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MRTSSMLFMPFVAFFGLVSARSATGDRVLVVLESAVTKDDYSQFWNSLQQRGFELTFKEPESKDADLVKFGEAQYDHLIMFAPTAKNFSPSISPKAILDSQFKGLNALYILSPQLPEVQREHLREYDLEFIPSDLVLIDSFSHPSGESASTVLLPPTECAVSNGAVLSDTTLTGGPIAYPSGTVHSAGLNPYLIDVLHAPKKSYIGQDKILNADEIEREKAVDGKKSKDALQTGKKASLVSALQTRDNARAGFVGSGEVFSDKYWGQTVETIDGKKVETGNAAFVTDFTKWVFQETGVIKVVSTTHFREGETEPREMYTKKDDITYSLTLAQHVTNGNGTSSWGPFYADDIQMDFTMLDPHIRTAMIEDKSSSSADATTYKARFIAPDRHGVFKFAVEYWRPGWSYIRTSSTASVVPLRHDEYPRFITGAWPYYIAAISTSVTFLAFVAIWLSLGEVDKDRKGKKKAE
The following text describes a protein:
Function:
Methylates DNA on the 6th position of adenine (N(6)-methyladenosine). N(6)-methyladenosine (m6A) DNA is involved in epigenetic transgenerational inheritance.
Sequence:
MDTEFAILDEEKYYDSVFKELNLKTRSELYEISSKFMPDSQFEAIKRRGISNRKRKIKETSENSNRMEQMALKIKNVGTELKIFKKKSILDNNLKSRKAAETALNVSIPSASASSEQIIEFQKSESLSNLMSNGMINNWVRCSGDKPGIIENSDGTKFYIPPKSTFHVGDVKDIEQYSRAHDLLFDLIIADPPWFSKSVKRKRTYQMDEEVLDCLDIPVILTHDALIAFWITNRIGIEEEMIERFDKWGMEVVATWKLLKITTQGDPVYDFDNQKHKVPFESLMLAKKKDSMRKFELPENFVFASVPMSVHSHKPPLLDLLRHFGIEFTEPLELFARSLLPSTHSVGYEPFLLQSEHVFTRNISL
The following text describes a protein:
Function:
Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity (By similarity).
Subcellular Localization:
Nucleus. Note=Together with BLM, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment.
Sequence:
MSGARRPGTSKRKRNWHIEHPSFREERSQQLRRGNFKTVEAADSLSKAWLKCGEGFQDTSEILSLASEKTGITEKHLELSPKPKTETTSKNASELPNIIWSSSESDFSDEDKTLPALQRDGRHGPRADRLGDRTISCPEDEDIEDELQVIDWEVNSDKEDPGGPSECEDDKGTLDISDCDSCASLTSDDRLCEPSEPISTEILEYSSDSEKEEDPEHSLFIDSESPHKYQADFKSDARWCLVSQTDSEANSAEPTLTPQKYTVKFPKTPEYSVTKKKLLRGGLAERLQELQNRKRSAISLWRHRCVSYQMTPLGRKSGVLTVKILELHEECSMQVAVCEQLAGPPITSPPGGLAPRPGAYLKVLFTRETADHLMGHPQDIIYIFPPWQKLLIPNGSCSIILNTYFCQKAIAKETVREDLYSPDISLSRRNITLAQTFRIKDITDNSSINQTTYDSLATPGTGWTHGHEKAEQHLIVAAPLRNSLLDIVESQRAGLWSGVRVQVVVQRVYSLLSRDGARSQQGHTVGHADASGAWSCLLVQDACGMFGEVFLNSTLWKSRQLEGKSCSMSGVKVLQKATRGRTPGLFSLIDSLWPPVISLTEPSCGQPSGETKTYLPPPIFCYIFSAHPTLGQIDAIEDHISKLYQPPVVRCLKEILQTNECSTRCSFYARVIYQKPQLKNLLAQKEIWLLVTDITLQTQDERDHSLPKTLPVYIAPSCVLGPEVVEELALLVSYNLLFRDAFKDNGQIVCIERTVILPQKPLLCVPSASCDLPSPVTLDELSALTPVNSICSVQGTVVDVDESTAFSWPVCDRCGNGRLEQKPEDGGTFSCGDCSQLVLSPLQERHLHVFLDCPTRPESTVKVKLLESSISLLLMSAASEDGSYEVESVLGKEMGPLLCFVQSITTQQSSCVVTLEEIELLSTEGATAAQPPP
The following text describes a protein:
Function:
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF3 forms the TFIID-A module together with TAF5 and TBP. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process.
Subcellular Localization:
Nucleus.
Sequence:
MCETYSRWLLRVSVAQICQALGWDSVQVSACDLLTDVLQRYLQGLGRGCHRYCELYGRTDPILDDVGDAFKLMGVNLHELEDYIHNIEPVTFAHQIPSFPVSKNNVLQFPQPGSKDAEERKEYIPDYMPPIVSSQEEEEEEQVPTDGGTSAEAMQVPLEEEGDMEEDEAINDENYLSKRPLESPDAEEFPPMKRPKLSVSKGDALDGALEPREPLSSINTQKVPPMLSPVHVQDSTDLAPPSPEPPMLAPIAKSQVPTPKTLESKPPAPKTKSKTSSPGQKTKSPKTTPSPVVAGSPIRSPKTGSKEKKSPGRAKSPKSPKSPKAPVHVPPPPVKPETPSRTPLAALSDKIGKENIQVKQGQTPPEPVTKPNIENQTKKLPVMDKTIDDSIDAVIARACAEREPDPFEFSSGSESEGEIFTSPKRLSVSETTATTPKPSVSTNCSNKAGATPVPPSGGTSSSDISWTMDDSIDEVIRKANMGTPSNPPANFTYFSSPSASPPTPEPLLKVYEEKTKLASSVEVKKKLKKELKTKMKKKEKQKEKDKEKSKEKNKEKEKNKEKDKDKEGNKEAKFQWKELLKDDEHDPYKFKLKDFEDADTKVKLKDGNTKKEKEKHKDKKKEKEKGKKDKDKKDKEKVKDKSKEDKIKPPSAPLVLPPKEMSLPLFSTPTAMRLPSMLPSLSPMLPEKLFEDKEKPKEKKKDKKEKKKKKEREKDKEKEKKDKEKERKEREKKEKEKEKHKHEKIKVEPVVPAPSPVIPRLTLRVGAGQDKIVISKVVPAPEAKPATPVSRPKTPPPVPSPVPAPVHVTPPPAPVPAPPQPTVSPALLPPASPAVSAAGGSKAPVRSVVTETVSTYVIRDEWGNQIWFCPGCNKPDDGSPMIGCDDCDDWYHWPCVGITAAPPEEMQWFCSKCANKKKDKKHKKRKHRAH
The following text describes a protein:
Function:
Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Phosphorylates the GTPase-activating protein ARAP1 following EGF stimulation which enhances EGFR signaling by delaying EGFR down-regulation. Also associates with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways; [Isoform 2]: Inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins.
Miscellaneous:
MISCELLANEOUS: The inhibitors bind to the ATP-binding pocket.
Subcellular Localization:
Cytoplasm. Nucleus. Cell projection, ruffle. Membrane. Note=Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate.
Domain:
The SH3 domain plays a major role in substrate interactions. The SH2 domain of PTK6 plays a role in protein-protein interactions, but is likely more important for the regulation of catalytic activity.
Sequence:
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT
The following text describes a protein:
Function:
Component of the spindle pole body (SPB) half-bridge involved in the initial steps of SPB duplication.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle pole. Note=Spindle pole, half bridge.
Sequence:
MGKFGTTNKSTENLLRDKFVPETSPTNIPTDVLIKQGQITDSTESLIHGGAERYIVNALKPIELNKTEGFFEDPPFHLPSPPVDSTNLEYEDVTDLPKNGLRYDLNDISVEVIEDLYRQIEAFLVHFKLSRSFLQIFKNYVNILIQEGINPLRDEYFTILEDELKGFFTFNSVIEEILEIFLIHPRNKFIALSLAEYTYAKNKIRRHFNHWKTVCELNEEANRFANQAKLRVQEAVFYIWSDKTLKYSQMANDEAESFRNTWLLFRSFQQWITLTQTLKEQSRLADQAFLNKMFRKILKAQEHWKHLETVNTDNIKKIFLRTTFHIWKLRHKEINYHGLERRIFERIKQKVINYEYNKSIAEKVRSFSLQRKYLNKWEKKNIENEDKLGALYELENKFIKQKFFRKLNRSFQHSQQEAIAKSKLNQTLLRCVFEKMWLKRFEDHLHLYSIVSLKEANLVKRIFHSWKKLLYIDLKASDYSRTNLLKSSLRSWKLEVKLKIFEQKCKKSIQASAYRTWRKRIQYGKISSEHVKTAFCAKYLGVWKRRMLQMNSMNDEASKFYEEGLVNECLAIWKERLIKTKELEDRYNFLCKTHAILTVKRTLMHIDNVHLLYTKLAPSMDRVKLSKAFLKWRKATRFKVRHKLNDILHVYEKSKERELQSQLFNAWRNRFCFYTEECNIQAISKRNYQLEKMVLKKFRERLLEIVKSEELADEVREEFVLVKTFYIWKTHLDEIFYMSTLLEQSEANKQFIITSKFLKMWSLRFLKIKRNDETVEVFRHRWDRATVRGLLLLWKNRSDSSPKRRKDFNLKHELKTPIRSDSQNASTIPGSERIKQHRMEAMKSHYSRARRAIPSPVKSSSVLDSTAKKQINLESTTGLNGSPTRGKPLRYSPRRTTRNMPSKVDHIDFGRIPAVPFSLSANSPKIDQDMDYIREHDKSPLSRKRQ
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.
Sequence:
MKSLFIGYFDGLHQGHLFLKQNSKFEPMVLLIDNPPLKQTNWLYDLQQRVAQIKTYLKATVEVFDVAKHNMNALSFFEQQIKRLNCDEIIVGTDWHFGNDHKDGIWLKKLFKNTVIVNKTNLSSSVIRNYLTNNELEKANQLLVEPYYRVGTVVHGLKKARLLGFPTANIVMDNHLLTLNKGSYIVRVLLNNQTFYGIGFISQKDQDLVCETHIFNFNNEIYGSLVKFTLLKFIRTISKFSSQAALQKAIQSDANFALKWLENQNLDKI
The following text describes a protein:
Function:
May function as a transcriptional antiterminator.
Sequence:
MTKRTIEQILDELRRGRRPLLADKPAESDASRYDCLRCKDQGGYLVRQNGLEVWTMCSCMAERKVKRLLGASEITHAFRQLGFKEFRTEGKPQAIKDAFECTKEYVADYEQIKDCRKNSIALLGQPGSGKTHLLTAAANELMRTCYVPVIYFPFVEGFTDLKNDFALLEAKLNRMKQADVLFIDDLFKPVNGKPRATDWQLEQMYSVLNYRYLNHKPILLSSELTIEGLVRVDEALGTRIYEMCSDYLVIIKGAAYELNHRLEGVR
The following text describes a protein:
Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.
Sequence:
MSSASVTAFEKEHLWMYLQALGFEPGPATIACGKIVSHTHLGVNMFDKLNRDAFHIISYFLFQVLDQSLTKEVFKFCWPPFDQKSDTEFRKHCCEWIKRISGECGSSFPQVVGSLFLSPGGPKFIHLMYHFARFVAMKYIKSNSKNSSHHFVETFNIKPQDLHKCIARCHFARSRFLQILQRQDCVTQKYQENAQLSVKQVRNLRSECIGLENQIKKMEPYDDHSNMEEKIQKVRSLWASVNETLMFLEKEREVVSSVLSLVNQYALDGTNVAINIPRLLLDKIEKQMFQLHIGNVYEAGKLNLLTVIQLLNEVLKVMKYERCQADQARLTVDLHYLEKETKFQKERLSDLKHMRYRIKDDLTTIRHSVVEKQGEWHKKWKEFLGLSPFSLIKGWTPSVDLLPPMSPLSFDPASEEVYAKSILCQYPASLPDAHKQHNQENGCRGDSDTLGALHDLANSPASFLSQSVSSSDRNSVTVLEKDTKMGTPKEKNEAISKKIPEFEVENSPLSDVAKNTESSAFGGSLPAKKSDPFQKEQDHLVEEVARAVLSDSPQLSEGKEIKLEELIDSLGSNPFLTRNQIPRTPENLITEIRSSWRKAIEMEENRTKEPIQMDAEHREVLPESLPVLHNQREFSMADFLLETTVSDFGQSHLTEEKVISDCECVPQKHVLTSHIDEPPTQNQSDLLNKKVICKQDLECLAFTKLSETSRMETFSPAVGNRIDVMGGSEEEFMKILDHLEVSCNKPSTNKTMLWNSFQISSGISSKSFKDNDFGILHETLPEEVGHLSFNSSSSSEANFKLEPNSPMHGGTLLEDVVGGRQTTPESDFNLQALRSRYEALKKSLSKKREESYLSNSQTPERHKPELSPTPQNVQTDDTLNFLDTCDLHTEHIKPSLRTSIGERKRSLSPLIKFSPVEQRLRTTIACSLGELPNLKEEDILNKSLDAKEPPSDLTR
The following text describes a protein:
Function:
Converts 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) to 4-(N-succinylcarboxamide)-5-aminoimidazole ribonucleotide (SAICAR).
Sequence:
MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD
The following text describes a protein:
Function:
Required for the formation of cytoplasmic actin filament bundles in nurse cells, possibly by regulating both the polymerization and organization of actin filaments. Mutations in quail result in female sterility due to the disruption of cytoplasmic transport from the nurse cells into the oocyte late in oogenesis.
Sequence:
MELSLSPKETEIRPNTIPDLKVDATFRKVAKHAITFAIWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASLSGHYANHETITREQKPNVSLERYIHYWLGKNVSEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFKKGYDVRSGALISAPQRPRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSSGIERRSALDWVQKHCSGSPITIVDDGYEQAMSQEHKELWNTMLPLKKRMVCQASQLVSEYADYNSNKFRIYKCNQRGRLHLDQLDVGMPAKDDLSDAHGVYLLDNYGQSIWLWVGGQAPQADALSAMGNGRAFVKKKKYPDNTLVVRVLEGHEPVEFKRLFANWLNVWQENTRGHKPVSTKFGKLDAHSLCERPKMAADTQLVDDGRGERVIYRVFGDQVQEVPISKTVVFTTNASFVVKYSVQCATVVPADLASVGIKTIIYQWNGSEASVESISRADKFAKASFDGLKEPGMFVQLYEFDEPPHFLQIFEGKLIIRRGQRTEMPYNGNSNALLDTFLLKVYGDASYNAKAVEETHLSSISSKDCYVIKTNHVWVWCGQSSTGDAREMAKAVGALMGENSLVLEGKESKEFWQSVAMYFNQTLVINGNGNSCSSSTSSSSGAGSMCNGSSNGGNISPTLSNNCYLNTSVPSKPRPPVQLFLVWWQQSSLRYEEILGFDQQDLSSDCTYILDTGSLTYVWLGSQAPNQERYTAIAQSYVQNAPFGRRSATALAVVRQFQEPNVFKGFFESWQNDYGKNFHSYEKMRKDLGNKVTSNCCFASEGSALILNNRQKDFDGHKKYPLTVLIQEMDMLPPDINPLKREVHLTHDDFVSVFNMSFYEFDELPKWKKMELKKQFKLF