lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide (By similarity). May function as an antioxidant involved in response to viral infection.
Subcellular Localization:
Cytoplasm.
Sequence:
MAHYEEVNVRGYDEFCQAVSERKGKDIFAYFSGDKDASGKSWCPDCVTAEPIVRGQMSHLPEGSVFIYCQVGERAYWKDSTNAFKKTLKLSGVPTLLRYGTPQKLVEEECFKADLVRMMFTED
The following text describes a protein:
Function:
Involved in cell wall lipids remodeling and in virulence. Restricts the biofilm growth and is essential for the optimal intracellular survival of M.tuberculosis. Shows esterase activity with a preference for short-chain esters, particularly pNP-acetate (C2) and pNP-butyrate (C4). Has weaker activity with pNP-octanoate (C8), pNP-laurate (C12) and pNP-myristate (C14). Shows weak long-chain triacylglycerol (TAG) hydrolase activity in vitro. Not necessary for PPE17 stability or for its localization on the mycobacterial surface.
Miscellaneous:
MISCELLANEOUS: Elicits a strong B-cell humoral response among different clinical categories of both adult and child tuberculosis patients; MISCELLANEOUS: Expression in non-pathogenic M.smegmatis (Msmeg) strain induces necrotic cell death of macrophage after infection and significantly decreased IL-6 production compared to controls. Msmeg-PE11 bacilli exhibit altered colony morphology and cell wall lipid composition leading to a marked increase in resistance against various environmental stressors and antibiotics. Mice infected with Msmeg-PE11 have higher bacterial load, show exacerbated organ pathology and mortality. The liver and lung of Msmeg-PE11-infected mice have higher levels of IL-10, IL-4 and TNF-alpha cytokines.
Subcellular Localization:
Secreted, cell wall. Note=Cell wall associated protein.
Sequence:
MSFVTTRPDSIGETAANLHEIGVTMSAHDDGVTPLITNVESPAHDLVSIVTSMLFSMHGELYKAIARQAHVIHESFVQTLQTSKTSYWLTELANRAGTST
The following text describes a protein:
Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the sulfate conjugation of phenolic compounds. Does not transfer sulfate to steroids, dopamine, acetaminophen, or alpha-naphthol. Except in mitochondria, where it can add sulfate to cholesterol producing cholesterol sulfate, which alters mitochondrial membrane organization, and impacts protein complex mobility increasing state-III respiration, thereby modulating mitochondrial respiration (By similarity). Catalyzes the sulfation of the carcinogenic N-hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity).
Subcellular Localization:
Cytoplasm. Lysosome. Mitochondrion.
Sequence:
MALATGPGKQTQLREVEGVPLQAAIVDNWGQIQSFEAKPDDLLICTYPKSGTTWIQEIVDMIEQNGDVEKCQRALIQHRHPFIEWARPPQPSGVEKAQAMPSPRILRTHLPTRLLPPSFWENNCKFLYVARNVKDCMVSYYHFQRMNQVLPDPGTWEEYFETFINGKVAWGSWFEHVKGWWEVKGRYQILFLFYEDIKKDPKCEIRKVAQFMGKHLDETVLDKIVQETSFEKMKDNPMINRSTVPKSIMDQSISPFMRKGTVGDWKNHFTVAQSHRLDELYRKKMEGVSIDFCLEL
The following text describes a protein:
Function:
Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.
Sequence:
MNSLTATAPIRAAIPKSYMHIATRNYSNVIAMSGLRCSGSLVANRHQTAGKRFISTTPKSQIKEFFPPPTAPHVKEVETAWVHPVYTEEQMKQVAIAHRDAKNWADWVALGTVRMLRWGMDLVTGYRHPPPGREHEARFKMTEQKWLTRFIFLESVAGVPGMVGGMLRHLRSLRRMKRDNGWIETLLEEAYNERMHLLTFLKLAEPGWFMRLMVLGAQGVFFNGFFLSYLMSPRICHRFVGYLEEEAVITYTRAIKEIEAGSLPVWEKTEAPEIAVQYWKMPEGQRSMKDLLLYVRADEAKHREVNHTLGNLNQAIDPNPYAAKYKDPTKAHPNKGIADLKPMGWEREEVI
The following text describes a protein:
Function:
May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
Subcellular Localization:
Cell projection, cilium, photoreceptor outer segment. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix.
Sequence:
MRPVSGLLSGKVTLPCYFSIMPTIGPRNKDASGYDYLRIKWTRIDGGVESTVLVTQNGVIKIGSGYRSRVSVQSHPEDIGDASLTMVKLRASDAGTYRCEVMFGIEDTQDTVNLNVDGVVFHYRSKVSRYILNYAQAVQACSDVGATIATSEQLRAAYEDGFDQCDAGWIADQTVRYPITRPRPGCFGNLPGKPGVRSYGKRKPTETYDVFCYVDKLEGNVFFAPTLQKMTFDEAKAVCESNNAELASPGQLHAAWRQGLDRCDYGWLSDGSARHPVSVPRSQCGGGLLGVRTMYRYRNQTGFPDPSMRLGAYCFQGVHSCSDAVCLNGGTCIKTGGAQICICQPGYSGEQCEIDIDECHTNPCRNGGTCIDGLNSFTCLCLPSYAGALCEQDTETCSYGWHKFQGHCYKYFPHRRNWDTAERECRLQGAHLASVLSHDEQQYINRLGHDYQWIGLNDKMFENDFRWTDGRVVQYENWRPNQPDSFFSSGEDCVVMIWHEDGQWNDVPCNYHLTFTCKKGTVSCSQPPIVHNARTFGQPRPRYEINSLIRYQCMDGFIQRHVPTIRCRGDGLWDSPRISCMSPSNYQRSYTRRLQRYSVYRNNRKRSAEHSVDVHRRRHHHHHHHHGGKHIRTKQ
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MSSGYGMNGGPSRCFPFWQEVLACYVVNSNEEDASGRKKCSPMLEDYYECLHHKKEAARVQALQAAYRKAEAEGGYKANPPTAGQIRNLGILGKEEDSRAVLGSK
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MLNPTNLKFSKKSKKKFRQEEEDGIVSMSSANEKASFQSFKGRDWHLEGAFDVFYNQPQIKTFTDSRYLERLYNRYKDPHVDMVLVDGITLLCNDLQVDPQDIVMLVVSWHMKAATMCEFSKQEFIGGLRALGIDSLEKFHERIPFMRSELKDEQKFREIYSFAFGWAKEKGQKSLALDTAIGMWQLLFAERRWPLVDHWCQFLQARHNKAISKDTWAQLLEFTRTVDPTLSNYDPEGAWPYLIDEFVEYINENGIV
The following text describes a protein:
Function:
Exhibits U-box-dependent E3 ubiquitin ligase activity in vitro. Negatively modulates successive stages of infection and development of rhizobial (e.g. Sinorhizobium meliloti) and arbuscular mycorrhizal fungi (AM, e.g. Rhizophagus irregularis) symbioses, in an ubiquitin ligase activity-dependent manner. Negative regulator of the LYK3 signaling pathway leading to nitrogen-fixing symbiosis (e.g. infection and nodulation) by rhizobia. May be involved in the discrimination of rhizobium strains producing variant Nod factors.
Subcellular Localization:
Cell membrane.
Sequence:
MNDPRSKMMISPGLLPTESLLDSLILISNEVSSMQKFPLVQIKNVSSMIRRIKLLSSLFEEIQESDSPLPPSSILCFIEIFSVITRVKVLIQECTDGSSLWSLIQLDFISNQFFVLVKEMGRALDILPLNLLNVAQDIKEQVDLLHKQSKRVELELFIDPREVQRRENLFEVMSKNCLQNKKTNNNKGFIDFVKVEEIMCSIGLRTLSDYVEEISKLEVEAQNQAGTGGLIVVSNINNLMSLVSYTKSMVFRNDGESEECKPISMFLYNKSKIHDNDSSSSSSFSQSMMTVNIPDEFRCPISLDLMRDPVIVSSGHTYDRISIAEWINSGHHTCPKSGQRLIHTALIPNYALKSLVHQWCYENNVKMNEAITKNNNSSSKRHKNENAIDHISENKASKDAVKMTAEFLVGKLATGSTDIQRQSAYEIRLLAKTGMDNRRIIAEVGAIPFLVTLLVSKDSRIQEHVVTALFNLSIYDNNKILIMAAGAIDNIVEVLEFGKTMEARENAAAAIYSLSMIDDCKVQIGASSRAIPALVGLLKEGTIIGKRDAATALFNLAVYNPNKLSIVKSGAVTLLVELLMDDKAGITDDSLAVLAVLLGCSEGLEEIKNSKSLVPLLIDLLRFGSVKGKENSITLLLGLCKEEGELVAMRLLANPRSIPSLQSLAADGSLRARRKADALLRLLNRCCSQPHHSL
The following text describes a protein:
Function:
Component of the transport system for branched-chain amino acids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKEIFMAKKGTLTGLLLFGIFFGAGNLIFPPSLGALSGEHFLPAIAGFVFSGVGIAVLTLIIGTLNPKGYIYEISTKIAPWFATLYLSVLYLSIGPFFATPRTATTAYEVGISPLLSDANKGLGLIVFTVLYFAAAYLISLNPSKILDRIGRILTPVFAILIVILVVLGAIKYGGTSPQAASAAYQASAFGTGFLEGYNTLDALASVAFSVIAVQTLKQLGFSSKKEYISTIWVVGIVVALAFSALYIGLGFLGNHFPVPAEAMKGGTPGVYILSQATQEIFGSTAQLFLAAMVTVTCFTTTVGLIVSTAEFFNERFPQISYKVYATAFTLIGFAIANLGLDAIIKYSIPVLVILYPITIAIVMIVIVNKFVALSKPGMQLTIAVVTVIAIANVLGSSFKVEFLANLVSVLPFAKASLPWLVPAIVGILLSLVLPNKQESDVFEME
The following text describes a protein:
Function:
Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, P-body. Note=Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body.
Domain:
The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
Sequence:
MGTFNLWTDYLGLARLVGALHKEEELDVRLDPKPEPKPSSESQQASKESSAAPERLCSFCKHNGESRAIYQSHVLKDEAGRVLCPILRDYVCPQCGATQEHAHTRRFCPLTSQGYTSVYCYTTRNSAGKKLTRPDKAKTQDAGHRLGGEAAAGVYAGSKSGRKPPGPSPSACCPSTTA
The following text describes a protein:
Function:
Inhibits secondary vitellogenesis in females. Has no hyperglycemic or molt-inhibiting activity.
Subcellular Localization:
Secreted.
Sequence:
YNIPLGWGRRDMPGCLGVLGNRDLYDDVSRICSDCQNVFRDKNVESKCRSDCFSTSYFETCIMALDLAEKISDYKLHASILKE
The following text describes a protein:
Function:
As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
Subcellular Localization:
Nucleus.
Sequence:
MASQASHVSVGALSGIFDATKPQISEPIVQCVQVKPLPPQANNQERYRVVFSDISNYVQTMLAIQANHFVTDGLLRKGCFVRLKQFQANSVKGKKILIVLDLEVLKELGEAEKLGEPKPLESKAEEEEKPQPTTISSNGFYGAKAQNAPSQISSRAQHTRPMQGSAPATIYPIEAISPYAHKWTIKARCTSKSPIKTFHGRSGDGTLFSVNLLDDSGEIRATGFNEQCSALYDLFQEGEVYYISSPCRVQIAKKQFTNLNNDYELTFERDTLVEKAEEQNDVPQVRFNFTTIGDLQSVEKDTTIDVIGVLKDVGETTQIVSKTTKKPYDKRELTLVDNTGFSVRLTIWGTTAMNFAASPESVVAFKGVKVSDFGGKSLSLLSSGSVTVDPDIEEAHRLKGWYDAQGRNENFASHASSVGTMSATKRDQLKTIAQVREEQLGMSEEPSYFTLRATVVYIKQDNLCYPACLSEGCNKKVTEVDPGQWRCERCDKTHPRAEYRYIMLVNVSDHTGQLYLNCFDDVGRLLLGMSANQLMELPQNDGKALGNVIQNATCRTWTFGCRAKIDHYGDQQRIRYQVSYAKPVNYSEEASRLADIIDSYSIS
The following text describes a protein:
Function:
G-protein coupled receptor which binds to the neurotransmitter dopamine with high affinity. Promotes the secretion of FMRFamide-like neuropeptide flp-11 in the RIS neurons which inhibits late-stage swimming frequency. Plays a role in modulating mechanosensory behavior in response to non-localized mechanical stimulation. Under mitochondrial stress, plays a role in bacterial preference, resulting in learned avoidance behavior.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNDLQWPLLGLFSVLIILALFGNLLVCAAILWDRSLRKQPENLFLVSLAVSDLLVSVLVMLFAAVNDILGYWPFGQFYCQFWISFDITTCTASILNLCAISLDRYWHISRPMVYIRYCNRRRINYVIVLVWLISAGIGAAPLGFGFGSKVTINNLTGLPVCEMRLPLPYAIGSSMVSFFLPAMVMVILYTKLYLYARKHVRSIKTQLQQATSFLIMQLASEKIREVTAATLKGEALLPPDSPATERTTMTVSRHYSRRSTTTTTTATPRRGDKKTSSQNKVESIRTSIFSKLNFLCPTRFKNQRSPQDPHTPAAHNRSNISDQKARLTLGVIMGTFLVCWLPFFTVNILRAWLPEIFSSKTIMAVTWLGYANSSANPLIYSIFNRDFRRAFKKIIVRVFGCCWEEPDLNKSISSRYAAPDNIERRRSCTRSSESAHDNNNDANATRLNLLSNNNEETIPE
The following text describes a protein:
Function:
Acts as a component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.
Miscellaneous:
MISCELLANEOUS: Present with 3050 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MLMDEYEENKDMCPICKTDRYLSPDVKFLVNPECYHRICESCVDRIFSLGPAQCPYKGCDKILRKNKFKTQIFDDVEVEKEVDIRKRVFNVFNKTIDDFNGDLVEYNKYLEEVEDIIYKLDHGIDVAKTEEKLRTYEELNKQLIMNNLERSRTEIESFEQRQKFEKEMKLKKRLLERQIEEEERMNKEWTKKEIVNRLSTTTQDINETIEGVKNTVKLKKSSARRKLEELNRVLKNNPYFNSNVNVQNSRLKDAVPFTPFNGDREAHPRFTLKGSVYNDPFIKDLEHRKEFIASGFNTNYAYERVLTEAFMGLGCVISEEL
The following text describes a protein:
Function:
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular Localization:
Membrane; Single-pass membrane protein. Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MSGSTGERSFADIITSIRYWVIHSITIPSLFIAGWLFVSTGLAYDVFGSPRPNEYFTESRQGIPLITDRFDPLAQLDEFSRSF
The following text describes a protein:
Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MNTDGGTAPPGSKTRMGTDGGTGPAASKDGMGTDGGTSLASSSDGPGTDKGTAPARSKPGPGTEGGTAPARSKTGPGTDGGTAPPGSKEGMGTDGGTAPGGSKDGMGTEGGTAPPGSSGGGGGPRGGWGLRRRASQKELRRTFARSKACPATRTYEEPAGVSALAGPQERPGGGRRRAMLRKASSLPPTSAHILSALLESRVSLPQCPPTALDYKCHLRRHSQPHFFLELVKDVSNDLDLTSLSQKILVFVRLLVDAHRGSLFLVEATAAGKKTLVAKVFDGQAGTPLRPHGSAHDPSEVQVPWGQGIVGYVGERGETVNIPDAYQDHRFNDEIDKLTGYKTKSLLCMPIRNSDGEIIGVAQAINKTPGGTRFTEDDEKVMEMYLPFCGIAIANAQLFAASRKEYDRSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFAKSFELMSPKYNADAENSFKDSVEKSPYSDWLTNNSIVELVASTGLPVNISDAFQDPRFDAEAEQFSGFHIRSVLCVPIWNSSHQIIGVAQVLNRLDGKPFDNADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAASIPPVSELAIGDIHFNDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQEILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFAKLSSKDYSDLMQLLKQSILATDLTLYFERRTEFFELVQKGNYNWNLQQHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERAELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNGKLKPMLDSVAANRSKWEEMHLKQLLTQAPSSPSSSSPSVPGPAADIN
The following text describes a protein:
Function:
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MAVQQVFCTIIFVVTILSNASAQDSTPSPRRQPKWCPVEVQEVKPYRVRSGSRTECRRACTWNRFCCEFNIIPVYTTAYRQVSRQEWKCCDDTVPCPDKTVSVDTPYKGIQLFADEYPVPPLPYEYDALEPYIDERTARVHHLGHHAGYTKKMNAALKAWRDEVGPGVGLQSNSILHILENLDQVPDKHRTAIRNNGGGFVNHAIYWATMSPRREGEPPRLPEATLATEIIANFQNFSNFQEQFTNTAKTLFGSGYVWLSRNPREQTLIIHTTANQDSPISDKLRPILVIDIWEHAYYLKHQNKRPDHIQDWWALVDWGQVKALSDWWAAYDAGHDEL
The following text describes a protein:
Function:
Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9. Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis. Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels. Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes. In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors.
Subcellular Localization:
Cytoplasm. Nucleus. Secreted.
Sequence:
MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMSNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK
The following text describes a protein:
Function:
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters via its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of tbp-1 and TBP-associated factors (TAFs), including taf-9 (By similarity). Essential for early embryonic development, but not required for transcription of some genes; probably acts via activating transcription initiation by RNA Pol II, as part of the TFIID complex.
Subcellular Localization:
Nucleus.
Sequence:
MADTGEKDTETTASGTDGHSKEALAVISMLHECGIQEFDPRVVSMLMDVQYAVTSKILQMSSGLSRHAEKAQIEAEDVQTAADMLGVLTTNAPDREKILQLANDKNQQPLPQIRHNYGLKLPNDRFCQLQQNFVYKADDSYQPMEMQQVTHQPHIIEPPTQVLRPEHVQNMLKRRAPDDDFDS
The following text describes a protein:
Function:
Possible regulatory or functional link with the histocompatibility cluster.
Sequence:
MVKKTSKAQKAKLRRAGSSTDDGDSQGGRGGQGGRGRGRGRGRGRGGAAAGGGRLARSALLPPDQQAAFESRRRTVQLEESAFSKLSPPVLERLNILASYADLRRPIPDELTRFTYSRFGRARAENHQRLVDHEHNKKEERNSHPLAGWLDNASQPPAKNQHQDQADSSSDDEHVDLNETIDPGVTGIEQTGELRLPKRPKWRSDMDTKTIHAQEEEVFRQWLRKTDAVVERAFFTSSPMFAGLTSHTRSQDKAAFGSSSSSSTAAMGGSRMVSSITSRDSIAQLLQHRPSPGTSVIGSLYERNIEVYRQLWRVCERSDLVCVLADARCPLLHLPPSLIGFLERYMRLKVIIVLTKADIVPKHIVDAWKTYLKQLYPRWEVVATESYAKLERMEGQGSRTRFAPYLSPHSRKDLFVALRKAHTDLITPPKVVQEDANKSKEWTPPCATDTDWDGVERRVQLHTEGFESGSGVEAQEDTGTKDERTTDKDSKDPKATRSHLPYLTIGLIGQPNVGKSSLLNALFGSKVVRASKTPGKTKHFQTHFLVPLRSSSSSTPVQADQPKAGGEESHRGQIRLCDSPGLVFPSLIGMEMQVMGAILAISQVQAITSCVRFVGEHIALEKVLQLEYPPDEDEVEEAQELWTGVKILEAVARRYLFKTAKANRWDVNRAGNLVMRAVAEGRIKWAFRPPSSAMVEESSMGEGVWFPEVERAVDQDTSTDLLTAPNPDDDEEHGNEKEDTDSKTSEEHSETDDDQTIARKVRFDFGAVESEDDGDEDDDVEVDQGGLGGSTNSLFSALAVEDGDDDDEDDEDEQEEDE
The following text describes a protein:
Function:
Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Vacuole membrane.
Sequence:
MSDLPLLGGSRNQGNFMHRAKKSVYNGTLSTLKSSPVNYLLIFVPLGIIAGELEWSATARFLLNFFAIVPLASVLAFATEEISEHVGQTVGGLLNATFGNAVELIVSIIALKDNQVRIVQASMLGSILSNLLLVLGCCFVAGGITRVQQTFNQTVAQTMSSLMALATASLLIPAAFHASLPTPKKGGGFPEPGSSDELILSFSRGVSVVLLIVYLFYLLFSLKTHKELFEEDQSADAILNERSQNSTLDVVTGPKTEEDGHLSMTAGLVVLLLTTILVSFCADYLVGSIDEIVESSGLSKTFIGLIVIPIVGNAAEHVTAIVVAMKDKMDLAIGVAIGSSLQIAIFVTPFMVLVGWAIDVPMSLYFSTFETAILFVSVFITNLVILDGESNWLEGAMLLSTYLIIALAFFYYPDVN
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MAWHIVEKLLEQVAEHSTLVGKFWVTFFFVLRFLMVVSIADTVFGDEQGSFVCNTLTPGCANICFNDFSPISLIRLWALQILSVSLPTIIFMVYTAHKMTKISQAKKLRQDEMDKKKKMREEAKKLKEEARKKAMADRRRRLEESGPPVKNEKKEKEPEKDKDDDKVVATKLDSDTPSRLMLAYVVQVVCRLAVEIGFMVLQFNIYVFKFWVPELFKCARWPCPNVVDCFVSRPKEKTIMLWVMFATGLIMIVLNLIELYHLGARKILEAWKQRGQDITKEYRVSSNMPHFGTHGGHGGGGRYPRGYPQAVGIRVGYARSSMSGEGGNDYDGDRFI
The following text describes a protein:
Function:
Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras (By similarity).
Subcellular Localization:
Membrane; Peripheral membrane protein. Endosome. Note=Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin.
Sequence:
MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLIITSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKLNQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSILFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPAQQEKLFGEKGSDRFRQKVQEMVDSNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVGEVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGDPRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPMSSVNLLEGLSRTVVYITYSQLITLVNFMKSVMSGDQLREDRMALDNLLANLPQAKPGKSSSLEMTPYSTPQLSPAATPANKKNRLPIATRSRSRTNVLMDLHMDHEGSAQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQLSDGGQGDVPVDENKLHGPSNRSNSVSSLDLEGESVSELGAGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVLGSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVLPSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPNKIEDLRSECSSDFGGKDSVTSPDMDEVTHGAHQLTSPPSQSESLLAMFDPLSSHEGGASAVVRPKVHYARPSHPPPDPPILEGAVGGNEARLPTFGSHILTPAEMEAFKQRHSYPERLVRSRSSDVVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGETEERKDSDDEKSDRNRPWWRKRFVSAMPKDDPSPRLSAQAQVAEDILDKYRNAIKRTSPSEGALANYESAEVMGDGESAHDSPRDETLQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLTHSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLLASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLESKEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERSVMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLKEAPWPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLSTVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
The following text describes a protein:
Function:
Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation, accurate chromosome segregation, centromere cohesion and telomere function during mitosis and meiosis. Required for both post-transcriptional and transcriptional gene silencing. Required for silencing at the centromeres and for initiation of transcriptionally silent heterochromatin at the mating type locus. Promotes histone H3 'Lys-10' methylation necessary for centromere function. Required for recruitment of swi6 and cohesin to an ectopic dg repeat. A member of the RNA-directed RNA polymerase complex (RDRC) which is involved in the generation of small interfering RNAs (siRNAs) and mediates their association with the RNA-induced transcriptional silencing (RITS) complex. RITS acts as a priming complex for dsRNA synthesis at the site of non-coding centromeric RNA. Its RNA-dependent RNA polymerase activity is critical in siRNA production necessary for heterochromatin formation.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome, telomere. Chromosome, centromere. Note=Associates with telomeric and mating-type region heterochromatin.
Sequence:
MAVSLNDFISVKLKRYSRESPWERLRVPYRNKKQKKWASVHNNEAQLHSANKRNDNCLIQRSSTWRLGDMITLVIKDIPVTWLSNEGGKLYNLWEPLHDYGTIEFMKINEPLNGQTSTTAIVQFAPPPKVPFWEPNGKINVKGVDLAVQIDITAHRSHISRQVFSKNSFRSDQLVKIPLSSFKLGQVYDERIVPLFGVDCGITVTESNLLVYFNFKKLCVLFDASFDKQIETFRLDFDFHSIIGDVGTDYYDDHISLVFRFRFSPLIFRKSKNATESRVQTFWTASHLWRRHYDILPFNVSPTTASPIELLNCHNAPIGRCNVLVLSFSIRDESDKDDIAFLLHNLEKFNLKSQLDKVVFHLVPDYKHRCSLINDKEIEEEIAYLLQACLSKNLLSEIDLPIILANLKKLSKERAKKFLRLILTSKTALINPSELDFTKSFVFYDLSSASSIHIKKLYVTPTTLRIVEDSLEAGNRVIRNFKDFANRFMRVQITDEYYKQKIRGGSDGFRNEKLYSRIQQLLTYGIKVGNQIYEFLAFGNSQLREHGAYFFASGSDLNAKQIREWMGDFSEINSVSKYAARMGQCFSTTKEINRFCVDISLQDDIVRNNHCFTDGVGMASLSVIRRLSLEVKNHDMFPSAFQFRMGGYKGVLSLAPPTKLEYHQGNLVFPRRSQDKFKSFHSTLEVIKISRFSNAHLNMQLITLLEGLGVEKTVFLELTRSQLSKMNESINSKQKSILMLRDNVDEYHSTLIIADFIQAGFLERDDAFTENLLNLYYEWVLRLIKEKQKVSVPKGAYLLGVADETGTLKGHYDDAVLSVPEIFIQITDTSTSFGSYSTGKLKTRVIVGLCIVARNPSLHPGDVRVCKAVRCDELMHLKNVIVFPTTGDRSIPAMCSGGDLDGDEYTVIWDQRLLPKIVNYPPLLESSPKKSIDFLEGKPLIDSVKEFFVNYIKYDSLGLISNAWKAWAHDHDNNPEGIFGNVCLELAEMHSKAVDFAKSGVACKMQAKYHPKRYPDFMQKTKTRSFRSETAVGKIFRYAARFQRESGRPATYNPIMNTVYDPCMKLPRFKTEYLNVAEEVKKHYDNDLRSIMARFDISTEYEVYTAFILFKDDLAKTVNEYGLREEVSFQFDLLKKKYTQEYLEKCALSNQSAFDSSEYEERINSAVAATYDVTYDQRVKSVGNGTTEVLISFPYLFSSRLCQLSRKAMLTANNF