lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II).
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MAVTLDKDAYYQVYSNWQKGEDEYANTWLFGYELTDTTMVFCDDKIIFMASKKKVEFLKQIANTKGNENANGAPAIRLSKSSFDKMIEAIKESKNGKKIGVFSKDKFPGEFMKSWNDCLNKEGFDKIDISAVVAYTVAVKEDGELKLTKKAAGITSEVFNKFFKERVMEIVDADEKSVEKAVEEKKYLAGADPSTVEMCYPPIIQSGGNYNLKFSVVSDKNHMHFGANTCAMGIRFKSYFQENYKFLLQLQEELLKELRHGVKICDVYNAVMDVVKKQKPELLNKITRNLGFGVGIEFHESFLLINSKNQYKLKTGMVFSISLGFSDLTNKEGEKPEEKTYALFLSDTVNEMTAEEKRLTEQKGEQEIQKAHKSNASYKHPSLMPKEPHIGEMKIYIDKKYETVIMPVFGIATPFHIATIKNISMSVEGDYTYLQINFYCPGSALGRNEGNTFPNPEATFVEEITYQTVPALNLENAFQIIKEVQKRYKTREAEEKEKEGIVKQDSLVINLNWSNSKLEDLYIRPNIAQKRLQGSLEARVNGFRFISVRGDKVDILYNNIKHASFQLCDGVMIIVLHFHLKNAIMFGKKWHMDVQFYTEVGDITTELGKHQHMHDRDDLYAEQMEREMRHKLKTKVEALTKEELEFEVPFRDLGFNGAPYRSTCLLQPTSSVLVNAMEWPPFVVTLDEFHLKNFDMVIVYKDYSKKVTMINAILVYSPSTGLKCLAFLEPEDEGSDAEEGDSESEIEDETFNPSEDDYEEEEEDSDEDYSSEAEESDSSKESLGSEEESGKDWDELEEEARKADQESSYKEEEEQSRSMSRKRKASVHSLGRGSNRGSNRGSTHSSAPPKKKRK
The following text describes a protein:
Function:
Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Required for efficient export of polyadenylated RNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway.
Subcellular Localization:
Nucleus.
Sequence:
MVTFEVKCFRNGDTEVRVMAHTCHPVVWRQRLHSELQPALSLRKDEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDDKLSEVEEAQESAMEADPKP
The following text describes a protein:
Function:
Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
Subcellular Localization:
Nucleus.
Sequence:
MSNESSQLAASSRLPTTTNQVKTVITDTPFVSTALEERRSRSLRARPSLSSPSMGIPSTTHPNGHATQSKGMEAISQGLRQEAVIVRREKRITEKERELKEVVESHDGLIREKFHLERFVTLLEGWNPEQAKLDNSPVFLQWKDSKHNLLNLLPDEPAISASSQAGPSRPRSSLPSRTTRRKAHEQSELLAHVVAPVAKPPAFAPSTKGKERVGDELHAKTKGKGKGLAEQSLIPSPAEGALHTKGGKRKVGDVTTDMLPPPVPDKRSRGSRRATMGAPLPQIDQNEEVGLDSQATHGGKAKRRGRISLPDLPTSKKLRTAKRASAVSSESASPVVEAPTLERLASPSPLSTPVPLPTFAHLPFPPAPHRIRKRIVGPRTIRYTDPSQRPPAPKYGGDITPIIESYVNINDTGPPPEMKTLEARAKKEGYLLARVMYLKSHGRLQRLVDEEDGSNLFSTTTTSNSHAKIIRIPPRKTDYHDTLIAHMVQVRNAMLNVAKSKPVTCKKVARMVQAYWENIEGKEERERLAEEKERRRMGKEIIKSLRKRWALAVKVVRAKILEAQKQEQDRLGKEHLQNILQRSTGLLEAQIQGSNDSGEEEGEDSTSDNTDDSEGDDETNTLLPLTSISPEPVIGDDEEDVDVHDDDDEQQGEEDTSHKEDESDASDTESDENSMSEHNQDLRFLISDDVLNEDPMSTGRFAEEDRGSSDTEQLTDNKNDGEEPKETAVQAAFDGSDDVNRLEEPHNPVSSTANIGNFALLESSSAEVSDASCPATMPILVRQSPKTCSQPRTRKVKLSTLSLSSDPDPDINDPEFKARLEDSNQDDQDEELDLEMEEADSAGRESGEGNRDSEDEGLLADADLPIEVLLRRYGYPVPEGEGAVNGEPEQSESKGREQAAPTSTVSETLPSTKLSLAQPANQTDQSLTDTALPEPRVPEQLIISGKRQRRKKEIWTPDDSEPQHLVGKKRIKKVEIVEKVEADVHQNGDGLVIVEEETMGDEDNDDSKVGQEEEDGHEYDSEEEYDEDEDEEEEGAKEDNVDWDDRQDKEGDIGPRVRQPFLLRGTLRPYQQAGLEWLASLWSNNMNGILADEMGLGKTIQTIALLGHLACDKGVWGQHLIIVPTSVILNWEMEFKKFLPGMKVLTYYGNQKERKEKRVGWHTENTWQVCITSYQIVLADQHIFRRKNWCYMILDEAHNIKNFRSQRWQTLLGFKAQRRLLLTGTPLQNNLMELWSLLYFLMPGGIGADATAVVGFANHKEFMEWFSNPMDKAIETGDAMDEETLETVAKLHTLLRPFILRRLKSEVETQLPGKFEHVVYCRLSKRQRFLYDEFMSRASTHEALTTGGYLGVMNTLMQLRKVCNHPDLFEMRPVKTSFAMDNVARDFEPSDILIRKRLLAEEDERRIDALAIGFGVAHNEAMSGWVARARQTYDASDKLPYAASPLRRGKLSAPPPKDTRSVELWLKYRVWAEEEFSKRRWESIRATNRQRCGISPIYGSTFLSLLGNLPNFLLPQDVQSRREETFADFTPPAAKFITSLPERAKSLEDVIDRFAVIPPNAVARNLATYALPGLEPISHPALTDPAFDTLHRSSVKLQIAFPDASLLQYDCGKLQKLFEMLRDLKSEGHRVLIFTQMTRVLDILEMFLSHNGHRYLRLDGSTKIEDRQVLTERFNSDSRIFVFIASSRSGGVGINLTGADTVFFYDSDWNPSMDRQCMDRAHRIGQTREVHIYRFVSSHTVEENMLRKAEQKRLLDKMVIQEGGFNNDWWGRVGWKDMFGDVPGITDVSGVVEKSGEGIIDIQVEGTPVAEDVEVTRPRAGEERELARALAEVEDEEDAQAARMAQGEGELDLQEFEEGPKAVAKRVRVFEPENSGTPVTTEAGETGDVVEEYDDEPGSVEEYMLKWVEEDWDYFSPYRA
The following text describes a protein:
Function:
Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.
Subcellular Localization:
Nucleus.
Sequence:
RRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHIKTHNGGGGGKKGSDSDTDASNLETPRSESPDLLLHDGAAAARGPGKEPPGGPGDS
The following text describes a protein:
Function:
Induces growth and cell cycle arrests at the G1 phase of the cell cycle; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Subcellular Localization:
Nucleus. Nucleus, nucleolus.
Sequence:
MSKLWRRGSTSGAMEAPEPGEALELSLAGAHGHGVHKKKHKKHKKKHKKKHHQEEDAGPTQPSPAKPQLKLKIKLGGQVLGTKSVPTFTVIPEGPRSPSPLMVVDNEEEPMEGVPLEQYRAWLDEDSNLSPSPLRDLSGGLGGQEEEEEQRWLDALEKGELDDNGDLKKEINERLLTARQRALLQKARSQPSPMLPLPVAEGCPPPALTEEMLLKREERARKRRLQAARRAEEHKNQTIERLTKTAATSGRGGRGGARGERRGGRAAAPAPMVRYCSGAQGSTLSFPPGVPAPTAVSQRPSPSGPPPRCSVPGCPHPRRYACSRTGQALCSLQCYRINLQMRLGGPEGPGSPLLAT
The following text describes a protein:
Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MWNKHRLAFILVGLLFHLFYLRSIFDIYFVSPLVHGMRQFKSNEEPPAKRLFLIVGDGLRADTSFDKVKHPVTGKTEFLAPYLRSLVEHNATYGISHTRMPTESRPGHVAMIAGFYEDVSAVTKGWKENPVDFDSVFNQSTHTYSFGSPDILPMFKSGASDPTKVDAWMYGHEFEDFTQSSIELDAYVFRHMDALFRNATVDSKLRHEMMQDGNVFFLHLLGCDTAGHSYRPYSAEYYDNVKYIDSQLERLVPKVREFFGDDDTAFVFTADHGMSAFGSHGDGHPNNTRTPLVAWGAGLNRPVLNDVPVYDNYTENWDLAHVRRNDVNQADIASLMSYLIGLNYPTNSVGELPLAYVNGTERTKLNALYKNALSILEQYLVKETEMIQSQLVYKEYPKFAQKSHSSYIQEIEHLIDRIANGEEDLEPEAIALSEELMKTALEGLQYLTTYNWRFIRSIVTLGFIGWITYSFTIFLRLFILEKQYAMKTSPQNLASFGALTAALNYVLYYQRSPFNYYMYLLFPLFFWSQILTNSTILHDGIREMFKGVSMLQRIGICALIVSIYEGIVYGYFDRWIFTIIFNLLALYPFFCGIKDAKTNMFWGANSMALSIFTLFDAVKIESLTQINVSGLLLVASGLYALWRVSKKINSHTKIVILLQILLLAMMLAVTNKSVTSLQQRAGLPTDAKIAGWVILTLSLSLMPLLHYLKPSNDYQVRVLVIYLTFAPTFLILTISFESFFYLLFTNYLMLWIEIESKIKAQNIAKNSQNWLQLLRISIIGFFLLQFAFFGTGNVASISSFSLDSVYRLMPVFDPFPMGALLILKIMIPYILLSTALGIMNLKLNIKDYTVSSLILSTSDVLSLNFFYLLRTEGSWLDIGVTISNYCLAILSSLFMIVLELFSHFLLKNVRDNGMDIAASKQQKRH
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MDRGVLVLDLDDTLICRKNSTIVKRPGLEEFLSKMVQVYKLIIFSASDSKQCVAGFGAFAHLISEVYSIKDCTRCRQGFVKDVSQFATCSMKRLVWVDDVRLNFRLCPHNGIEIRPFKGEADDRELEKLTPLLLKLSKVEDVTQFLWNGQPKMAEEGKPVLVLDLNETLVWKKDASTIVNRPGLEAFLSRMAMAYSLVIFSVSDSRHLDQSVAGFGASAKLITDVYGIEDCTRTRTGFIKDVRKVKVRHELKRLVWVDNERFHFRLCPHNGIEIKPFRGEADDAELERLTPLLLMLSQVDDVTQFLWNGQPKEEAQEQYTGKNPGKPKAKKKK
The following text describes a protein:
Function:
Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Purified ATP synthase is 25.9 nm long. The hydrophilic A1 domain is 9.4 X 11.5 nm, the central stalk is 8.0 X 3.9 nm and the membrane-bound A0 domain is 6.4 X 10.6 nm; the domains are connected by two stalks. ATP is synthesized or hydrolyzed by the A1 domain while ion translocation occurs via the A0 domain.
Sequence:
MRPVRMKKLKAVILDEKIDNVVRSLHEEGIVELCDLSEKLEDLEWKTLLSPSSSADYVRNVTSLMIKAGRILDMFSSVSQKETSIKDILNPKPVEKKKVSFNSYQEVIDYAEKVLNEISKEVDGPAERLSELDNKKSKLLQLKEQISYLKGLEFDLKYLGSGEYVFIGAGSVPKEKLGELKAELDKVADGYIGIFSGSEFEKDKKIRVPIVFVTLKEKLENVLSEIRKFEFERYDISDVEGTPSEALSKIESELKAIESERNSLIEKLKALAQKWEKELLAVYELLSIEKARGDAYSQFGKTDRTYYIEAWVPARDAEKAKSLIENSADGFAFVEITEPDEPEEKIPVLLDNPKVIKPFEMLTEMYALPKYNEVDPTLLLVPGFLLFYGIMLTDAVYGLLLTIIGLFIWKKIGKVSEGANKLGYILTLAGISTVIMGIITGGYLGDFTYEFFGFDVTKTPLALVNPLGESYYINNNNPLFTLGSISVTNGPMAILVFSIFVGLIHLLIGLFVGFKENVKRGNMGDAFINQGVWILLILSIFVGIGLMFAGANTMIAGGIIGIFVVLAILASMYKGYKSGGVMEAILGAMDVTGFLGNVLSYARLLALCLATGGLAMAVNIMAKLVGESIPVIGIIVAIIILLVGHTFNFVMNGLGAFIHSLRLHYVEFFSQFYEGGGKKFSPFKANREYTTA
The following text describes a protein:
Function:
Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.
Subcellular Localization:
Mitochondrion.
Sequence:
MTSTVASESVTKMHDDKRFKPGAAKPFVGDLGVRQGFLDAIGNTPLIRLKRASEMTGCEIYGKAEFLNPGSSVKDRAALYLIKDAEERGLLKPGGIIVEGTAGNTGIGLALVANARGYKTVIVIPKTQSQEKKDMLLIAGAELVQVPAVPYKNPNNYVKYSGRLAEHLAKTNPGGAIWANQFDNKANRQAHYETTGPEIWAQTEGKVDGFVCAIGTGGTLAGTGKYLKEKNPNIRIGMADPMGASMFNYYANGELKSEGTSLTEGIGQGRVTGNLEGWGQPTREGGVVDFWCQVPDEEALPLIYDLLKEEGLVMGGSTGINIGGAIKLAKELGPGHTIVTILCDYGTRYQGKIYNVDFLKSKNLPYPEWLDTSTKTSQVPSVFVDPEAV
The following text describes a protein:
Function:
Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAASEENSALFPIFVLTLMALPLVPYTIVNLFGAFKKKAAKINCQCSVCVRSGKYHKSIFKRISNFSTYSNLTLVLLWVVMAVLVYYIKHISTEFQIFEPFNILGLEHGASDSEIKKAYRRLSIQYHPDKNPDPEAHSYFVEYISKAYQALTDPISRENFEKYGHPDGRQGLQMGIALPQFLLNIDGASEGILLLGIVGVCIILPLTISVIYLSRSSKYTGNYVMHSTLAAYYHLMKPSLAPSKVMDVFIKASEFMDIPVRRTDEEPLQRLFVLVRSELNLDLKNIRQEQAKFWKQHPALVKTELLLQAQLTRETAALSPTLQRDFRRVLELAPRLLEELMKMAIIPRPPVGHGWLRPAIGVVELSQSVVQAVPLTARKAAGGSSEGYAPFLQLPHFSEAVVKKIARKVAIIAFNLFSNFLNTSAECWIGAHDKL
The following text describes a protein:
Function:
Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (By similarity). Involved in the differentiation of retinal ganglion cells, photoreceptor population and optic nerve development. Required for retinal circadian rhythm photoentrainment (By similarity).
Subcellular Localization:
Nucleus. Perikaryon. Cell projection, axon.
Sequence:
MKPRRPSCADSGSDSDSRDPEKFESAMRRRMAANARERKRMQGLNTAFDRLRKVVPQWGQDKKLSKYETLQMALSYIMALNRILSDAGRHVDPQKDWLNLQFDGLQTEGYFMHYDSPVESDCMLSSFSYHYESL
The following text describes a protein:
Function:
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
Sequence:
MFILPPPQEALLGAHTSAAGGLHNALYEGRDIGATTVQLFTANQRQWKRRTLTQEMVDQFRIALNETSLSYIMSHAGYLNNPGAPNPEILEKTRVCMHQEIADCISLGISFVNFHPGAALSDSKESCLDRTIASFSQMAPLFENNPPLVVLLETTAGQGSLIGSSFEELAYLIQGIKAHIPIGVCLDTCHIFAAGYDISSVAGWEQVLKHFDAVIGLSFLRAIHLNDSVFALGKNKDRHAPIGEGCIGSDSFCFLMQDERTRMLPKYLETPGGPDLWTKEIRYLQKVC
The following text describes a protein:
Function:
Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 26 nm in diameter, and consisting of 89 capsid proteins dimers (178 capsid proteins). Involved in viral genome encapsidation through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome. The capsid also contains 1 copy of the A2 maturation protein; Acts as a translational repressor of viral replicase synthesis late in infection. This latter function is the result of capsid protein interaction with an RNA hairpin which contains the replicase ribosome-binding site.
Subcellular Localization:
Virion. Note=The shell is composed of 178 copies of the capsid protein and 1 copy of the maturation protein.
Sequence:
MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY
The following text describes a protein:
Function:
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Sequence:
MRRTRSSALAEAPQRLRSLRSTARNPPLSPPPVASLRRSRRQPTVTKTLIKSEEQDAGQDDELDEDEEQDEQQDVGLTEYERKRRENIQRNMAFMQQMGVSTAKISARTAVGDESAKETKRQQQAVKRALQAARIADRLTQPVRKSRRLEGKKVEVEPIEAIDQFEMDKMRGPRPPRGSHLHVMDAVDGESKAFLGGITADLEEELEEDTVLADDDGVEYTLADDDITKAVQERIYSVAFLPRTDRVVVACGDKMGHVALWTPLSEAAVKQESSAPPLAVYRPHYTPVSQLIFPDASKLVSSSFDGTVREFDLRAAESSVVYEATDGAGISSLATASTSQCYYASCDDGTVRLIDRRAHKVKSSSYTLHEKKINTVSQHPSLDFCIATASLDRTVCLWDARKMSSKKNTPLIALPHYRSVNCAYFSPRDGAWLVTVGQDSYIDMFDTSSLTERKASDKSAITLPDSTRVRHNNITGRWLTKLHAAWDPKRPNQFVMGCMEQPRRIQIFRAGRRRPVRELKSDNFASVHSINAFHPHLELIAGGNSSGRLALWRGKKTDEPGDVKTEAKDKVKAE
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.
Sequence:
MQQSFRQLEERNLSVEVTLMQWSPKMDLIALANENGEVLLQRLTWQRQPIWTLSPPSEDEGKEVRALAWRPDGKVLAVGYQSGRLLLCRVEKAEVIHTTHVDQPITCMQWSAALDKGLDSEANGQSSVKADLGAAGDAPDENSSEKFLPKLPSLSKISSIKSYIDDNVEDAKKLKEQKRLNMLAVGCNGGTLILLAFGVAPIVNVDMSQFIPTTKCGDFLGASLSSDLHTICVIVEYSNEEDVTEIYNSLLTLDCILLASRHQEISRYAKKFGKIRTLMEYLEATLKAVTEAKEDILIEMENKLTKYAQQKPTEESLSDEFLQLLLWGKASPELQQFLVHDLTEKGLKKLDQSVENSYVSIQKLVLKHIHSVGRSLLFQLSELKGMALWYDKYGMLGLNATAIQDAISAVGSFMLKANELLQVIESSLKNFKAFFRWLYVIVMQLMEEPIQQSISKMYQRDINFVADFLAENFTDEPSLDVTKSGFTLERVGQYLRKEDLQFPVSTAPNSWQDFVASSPSLRGSDLLFPWQRERSLSQLHDVVKDAVDHALSRPQSVGGESLSCRESFTLDKRSETDHPEYRTLSQQSLQDQSKLLTVFMTEPSPAQCIYMTRQHTKPDRSSQNETEMVCLTFGTLGRSDPDESIVSLAAESHLVLDAAFYGDHSLSLLLQEVKDEGSINNGKPVLCQLSLESLQAEVEFTPMSQVKGHLSSGQHISIDAGPLVTSRRMDNMRAGRLAVSGSRKVACVLFSNQRRVRLFDMDAEDEGEDEEDDEENQLEDSSMVVAEEGSGTDN
The following text describes a protein:
Function:
Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MSSSIEEVKATIKSVKLTDSQAEKLSKLIDSLPKILSGLDNPEYDEIFGYRINTKDKPYVDESIRNEILLKFLAADDYNLELSEKRLIDSLNWRNEFQPLSAAFEETFDKELNELGVITNFPNSNLKITTWNLYGNLKNPKKIFEKFGANNKVSKLPGSQFLRWRVGLMEKSLQLIDFTSTTDNRIAQVHDYNNVSMFKIDPGMKKATKEIITIFGANYPELLSTKFFINVPLIMGWVFTFFKTIRVITEATLKKFQVLNHGNLSESFNPDELPKVYGGKVEKSLFDIDVSDDIKLSEYGEVILKKVGDEEINHINDDVE
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MSLKSFFNFNKKTKLHDIEEDVISEIGSAGSALRTDAHMLKANDVYYKSETDSHTVLRFMKPSENEKIHPVRHSKYEDKSKLPFETIPDPVLKYVKRARDAELQPQLAKVSQKLFADISTATAAEKLQFTVPRRARFEINDPRNPTFSMMALQDIISVLEYRRNKNPTSTAHICIDKKGKEAVSYSWDKILNRAKQFASVAQNHVGLKPGTRVILYYRKSEASEYIISIFGCLLLGIVVIPLSPSSSSESLKLVVNEEKVRVAFTTEATYRIFIKDTEVNNAKSLAWWKSNDFTNYKFEQIKQYRMRANDTVLIDYTFSSSTYNDIKAVYTTKTFLSQMRNLTSSMITNPARQAGWKLHNFEDSKDVLITNFHPSMPLGLIMGVFNSVFAGYCTIFCDEEVLKTPGLLAYLITKYRCTYSLFDYAGLKQTVYNYQEDPKSTLSFKKNYTPNLSSLKLCMVECEVVDPEFNIIVSDRWLQPLGTNNSKEVITPILCLRKFGGIPISFKDWMISYTNRQKHERQMADTCYQEILVLKSSIEKEKVEIVPFLDIRKYSPNEVLCMSPFWYPIPEASVAVVNEDSKNICKVGEVGEIWVYSDCLPKLKAASVINNPQGEQLTDYENNQENKFEKNNSFMDSGLKGFLHNEKIFVLGNKDEQIRQYRKTMVADKLMEEKYVHYSHYLIKKIMKYVPEIFDGVAFEIEIDKAVYSVLVLESPIIKRSLIRNNRLKGRDLFSELVKITESSFQVTQDIFKLDVLSILIAPYKSLPRSRYMGIQAINTNKCKLAFLSGNLPVSYVRFFMDSALPKSKINLNNSKGIWSKDASKHHREIISLNVKQKMDPYKHQNKVSKARENLLNHFTILDFLKTKSAKTPTSPAILTFNAIEKTKVELTWAHFELKVASHVEYMQLSVKAKARSHILLLYYDPLEFLISIHSCFHLGVIPIPFQIREISQLIGEIEEFTKIAKAFNVEAILVDHKVLISLKSRDISNHFQQTCIDLNMKAPKIFETTGIPISKRAKKALNLITPGELNNKGKVALISINKLEDGSIIPTQFSHSSLLAFCHEQKEFVIGNEEKPIIGGIEFSSGMGLLHTALLGVYAGVPTLLIKQENLCNNGSLLFEAIEQNSLSKVMIPLNICQKSFSTAQGCNSIVINSTLSSIIVPCYDRPISSRVNSIIEDIARIGLAPNKVKLAYSHPINPFVCWNADSSMEKMKDYFDANQLRSGLVNVREDVLRNRQPLLYGSGTSTLYNEICIVHPEEKYICQEGEIGEIWINGKHGSYCENNELNSGCELLVQETLDKKSYSRTGQLGFIHHLKKKDQNMEKVPVLYTLDFIWNTLELNGLNHSVKDIEETIELVHPNICTDGCILFQASGSVVILLEVHSQQKFASLIPIIVATALAAHEIILDCVAFVPKGTFLRRPTGEKRRADILKQWTGGDLKHMTSYLIRQDFLLNEDFVGTELIGTTDSYDYSDENLIINSSQLNLL
The following text describes a protein:
Function:
Adenine glycosylase active on G-A mispairs.
Sequence:
MKAAGRKRRKVCPTMEEKAQKKTATEASRAAEEEKVKKRTAVKASARQCHREGMESGSTLGDIEDFSADDAQRIRAALLRWYDVHRRVLPWRTANSGGIRGNGEEGKEVDQERAYAVWVSEMMLQQTRVQTVIAYYNRWMDKWPTVHHLASASQEEVNEVWAGLGYYRRARFLLEGAKSIVQEGEFPRTASELRKVRGIGDYTAGAIASIAFNEAVPAVDGNVVRVISRLKAISANPKKSTTVKGIWKLASQLVDPLRPGDSNQAMMELGATLCSTTTPGCSACPISEACLALSLSRSSGSTDVTDYPSKVAKTKQRHDFAAVCVVQLTEGSDEESLRGRNNNDVLLLVKRPEEGLLAGLWEFPTVLLDEEVIDVGTRRKIVDKYLKELFHINLKEICNVILREDVGKYVHIFSHIRLHMHVELLILKLEGDLRQFSENIQCTSAWKCVDGKSMKNMGLTSGVRKVYNMIQDYKKQQLLQCPMLSLRKKCKSSI
The following text describes a protein:
Function:
May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLRDALDFNSSGSGSEGSVFTKSEHSIIAAYLIVAGIISILSNIIVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQVYAGLNIFFGMVSIGLLTVVALDRYLTISCPDVGRRMTGNTYLSMVLGAWINGLFWALMPIVGWASYAPDPTGATCTINWRKNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSQSMRLSAASNCTTHLNRDWAHQADVTKMSVMMILMFLLAWSPYSVVCLWACFGNPKKIPPSLAIIAPLFAKSSTFYNPCIYVAANKKFRKAMFAMLKCQPHQAMPEPSTLAMGVPHSPLAPARI
The following text describes a protein:
Function:
Required for proper architecture of actin filaments and for cell movements during embryogenesis (By similarity). Plays a role in the radial actin fiber architecture in skin epithelial cells, thereby maintains cell geometry, size and cell interconnectivity within the skin. Plays an important role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology and maintenance of dorsal aorta lumen expansion during embryogenesis. May further play a role in the polarity, proliferation and migration of endothelial cells, and therefore participates in angiogenesis (By similarity). May regulate the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites (By similarity).
Subcellular Localization:
Recycling endosome. Cytoplasm. Cell projection, podosome. Cell junction.
Sequence:
MPLTESAWNESVGWFSSDHKYSTSSNKMRGEEASGTVLHRLIQEQLRYGNPTDAHTLLAIQQQALRRGGGAASSSQSSSESLSQDEPHSPQLSTRQEPQGQEHQVDYQHSENYTTYPHHQEELPTYEQAKAHSQYLASQWCLPHRVCSLQDSVAIQKPCEEQDSWDMKQGHVRSISDRLLHFSMESGKMPCSASYPQINGYHANQHLQYNQQGLEYNKLAPYTEYPFSVEYENGYKAPPPFHSQHNRLPTPEVCHRLSTSPPAGREVNACSRSQLEMLMNENKRLRQELEGQTEKALKIQKLEQEIQRISEAYDTLMKGCAKREALEQALRNKLMAEIKRLQHSSVQAAKQAEAADQNQHAIEKLHLQNEEQKLRCACLEQEVQHLRNEAEKHQRRSEALESTLRSTQTRSQQLWTELQRKRAYVEKVERLQGALTQLQATCEKREGLEMRLRTRLEQELRSLRNQQRQPQPVGGTSHVSVYTLQENLREKEERILSLEADKIRWEQKYLEEKTMREFAMDAAATAAAQRDTTIINHSPCHSFIEELPSTEYRNQEVENRIRSLYAQILEKDTVISILKQKLQHEQKGQLGALQPATADSSIISSHSTPAHTAQGKERSHFNDQAAGTLHSSHAPVEALAHTTDQTPHTEAKPKNIQKAPSAVDLFKGVDDVSAEAVEIFI
The following text describes a protein:
Function:
May protect dormant spores from desiccation and play a significant role in the formation or survival of microconidia and ascospores.
Sequence:
MSDFENKNPNNVLGGHKATLHNPNVSEEAKEHSKKVLENAGEAYDESSSGKTTTDDGDKNPGNVAGGYKATLNNPKVSDEAKEHAKKKLDGLE
The following text describes a protein:
Function:
Part of the ABC transporter FtsEX involved in cellular division. Encoded in an operon consisting of genes ftsY, ftsE and ftsX.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAIVRHKQPPLRRFMMYWVDHARQAFSSLGELWRNPLASLMTLAVLGVSLALPSCFHVLLKNAEVVEGSWQTSSQISLYLRKDLPEQSILDMKQRILLYPEVESVTYMSRDEALKEFREISGFGDALDYLDSNPLPPVLSVIPDPRWQNPEGAAELLNKLNNEDGVEQGKLDLQWLTRLQGIMNLLRHTITGIAVLLLSAVLLIVGNTLRLNILNQRSEIEVLKLVGATDAFIHRPFLYTGIWFGVIGGMLAWWLTEVMVIWSEGVVNELAGLYNSNFRLVGMGAVDGINLILLGALLGLIASWFSVHRHIRDIEPS
The following text describes a protein:
Function:
Receptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal, such as 3-oxoacyl-CoA thiolase. Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol. Cargo protein-binding triggers interaction with PEX21 and formation of a ternary complex composed of PEX21 and PEX7 along with PTS2-containing cargo proteins, which is tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome matrix.
Sequence:
MLSLRTPGFQGESVQFSPLVENKIAVAAVTHYGLGGSGRLYIHDVTPKGIQVCQHYDVEDSLFGVRWSQNCENQVYACCGDGSLRLFDLTMPSKPIHKWKEHKAEIVAIDTNTVDRRIVVTGSWDGTIKLWLGNLPNSVQTLNNGSNSRILTVATHYSSPNLLGYTSSDGLCKFWDFRSSDKFMSIEIPNQITCMNWSKSNHRMVYTADNNNLVYCYDIANLKTPLSVLSGHQLAVRSIKSSNSAHDLLATASYDMTSRIFDPEQHSCIRKVDLHSEFVRDVDWSDFGDGSWIASVGWDESLYIWNAF
The following text describes a protein:
Function:
Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of meiotic or mitotic spindle microtubules around them (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Associates with meiotic or mitotic spindle microtubules, particularly in the vicinity of chromosomes.
Sequence:
MDAPTLSELEGLRYSELQKLAKTAGLKANLKADKLLKALKVHFYPESKDESPDSDGCTSLTDTDELNSSQEKEEPVSVSFVTHRRGRGRKPLQNQAIPKDEFLSDSAGVGSESLASEIDNTQDKDCLESKKKEVSLPILDNKHKKRSRSQDTSKQNNSETTEKRQKKASNVSSIPSAGKIPRYVGRLSKPGSKPSTPNFKKLHEAHFKKMESIDKFMERKQKRLDAVSSSIQEVKMLTKKSNLLKLVEKTPVSDIKKPVKSRLSLLSPLPRTTGASPSRTPMSRRRSGRFSTANKSILVDRSGFKPSVLSSSKMNVRFSEATKDNEYKRSLIKTPARKSSSFLPITPKSEPRQTLSSIKKTDLLTSPEKAKKPDHNTTIQPSPAITESPCQQNKANTPFKFMAQNTETPNTNKKGSFDLQASLSRPLGYQPHRGKLKPWGESKENKSGSNSNVSVLKNNFKQPQLQTREERRKQHELDRKGKRDQALGTRRGVPVK
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MQPAARLLSRSVWKGPNIVPLPIREAMTKGTPIRTNARAATILPQFVGLKFQIHNGKEYVPIEISEDMVGHKLGEFAPTRKRFSYTQTKNK