lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEKSLEGSGKVPRIVQVMCFNGVPRQVTQPPSVTLPPQWDTQMLEFLKNSQTEGGNPPLTDAVPWDDAKTFLSAFEQVAEVCQWPKEEWVGRLLPGLRGGVEQFFCRMSPQDRQDYQKVKATLLRADNFRMELKRQHFRQCTYQELEGPRRVYSQLQELCRQWLKPEKHSKEQIVELIIQEQLLGMLPLEVRRFVQDCAPEDCVQTVALAETFLLARQQTSQPWNWQAPMPGMSTNTMMAAASGMSTNTVVSAASQLQRCAEASQKANGETNLIAKTMPPARSSDVVPPPQVQEGTGIGLMKEPVKVKEEPDFDLRPTCSEFVRDVTSVGSSSTASVLTQEGFFTPALQTIPQPVQQEPIFPPKSDHEQPIPNTPLGNIMLSGIKTEDNQDSGSDTDVSFEFPPEDSSWSDMVQNTEKNQGSSETNPPPQVPQEETSSQIQQKNGRRCPPVKKHLCSECGHACYYLSDLLKHMKKHSKELYKCSQCGKGFKAKATLTAHEKTHAAPDNSSSTNLAEDQTEGGYICCECGISKATELGLTEHMKVHTYDKHFQCEICGEVFKLKASLMKHQMLHNNVKRIVTLKGGNDPPVRQGVKTLRVVLTKLGSRTGKLHKCNECGYGFDKATQLTNHMRSHTRQRPYKCNDCGRSFRWLSSLQQHSEVICPKRHQVTQTVEKQIKEEVFLNRDIKLEDEELMDEAAAAAAIEPMSHQAGKAPFMGHLQQTPMPQQQAAPVSVAECDVTLTDEEELINLLQQGGSKLSHLPGKAKTGRHPKNMELPKTSRYDKPEKKHQCPDCDYRAYYLSELERHRKRHNYSNPYRCQTCGKTFGKKSALNNHYKKVALCQENSAKRIPVGPGDKKHTCPKCGHKTYKLSTLLVHMRTHGGENPYRCQQCGQTFSFHTDLMRHETLSHNLESSSSSRKPYFFKHMTKHIADNMKPTEVNEENLLLNNPNNTLVIQQDAPVIAMIRDRWRYEKPEQQLQDDDDDDPDPVETSEEVTVEAKEDVAEKKAAFRAILGKFAYCKTTESDQTEPSTNEAAPAEAKPSYKCLTCGQTFEMKIDLTLHENTHVLPKPVESRERQPDFSLWSKNLLKYHLGQTRPKPHPCCDCGKEFYCRDNLVIHLKTHGFENIYECGECDEVFVQQEELVRHKRCHGEQEP
The following text describes a protein:
Function:
Endochitinase that cleaves beta-1,4-linkages between tri- and tetramers of N-acetylglucosamine (GlcNAc) from penta- and hexameric chitin oligomers. Does not cleave smaller chitin oligosaccharides. Required to cross the acellular, chitin-containing peritrophic matrix (PM) which is formed around the ingested blood meal in the mosquito midgut allowing the ookinete to invade the mosquito gut epithelium.
Subcellular Localization:
Secreted. Cytoplasmic vesicle, secretory vesicle, microneme. Note=Enriched at the apical end of the ookinete.
Sequence:
MNFTVKYSFLVICLLCCLLSTYVSVIEGHRARPGESRKNPREIIKTFKESGKGIIQGYYPSWVSYNHNLKDLNPNLNVVHMSFAKMDLSYDSIESIVGSPLLFKSLIGLEYIGLNEYFNDAMNLRKARPDIIMLLSLGGETYHPSSFDSALNAVEKIANLVDELGFDGIDVDYEPNGSFDGLNDKEKADFFVQYVTKLREYMCDDKLISISQSSNGALSCIGFNDPKKICMDDEAPYNSKYFNKPDVKKELLRAAQMASAGGAIYLMNNLKDMIDMVFVQTFNYTNSTDSTVMKELYDSYAYYGKKYDYVIIMGFTLMFPSTPFNPNDKMLVKSIGDFVKTENKLNKRADGFGLWSLSSDNAAHNEQLAIEYFVESLH
The following text describes a protein:
Function:
Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs.
Sequence:
MGPLLEKAYGSDADASVTRHCLDVLGVVYLSLGPKNPLKKVLASTLNSLPDQLLAVAGHSFTRHLLAELETADVKSYPKVMDNLACCLEDFHLGEVTLSDSLRVRKTPSAGGGRRGAGQGVWGGRGMGVAQGLAGLGSSHTLMVLCAGARPCVGDLPQNIQSTAGLAVILLTKTMWDRPDGVPELVSAALDRAEQDQAGVPAWFRSSCRSLCLGPIPDPVLLFLCQGALAMLDWKGGQLGPSGDRLLLDIARVLSSLSSRVKEPSLEASLSRILVSWTSSALELLSAGSPGLRASLAGTSPTAGPLLDYVFAHWDHPLDAVRHQARLVFRNLLRLHQLSQATPTSTLATAWHVQGKFAALRCLAECVGAAGLLALAPTLPSQVLAVMGDQALAPHASDLLEALFLSHRAGLQHQHPVTKAWVAPWLTTWVSPLLPVLCEGDLAQTTHITDYYLPKLLRCSPAGLGHMVDVLQASVHAGHGGRGPLGALMACLRSARAHGHLQASALGPWSRLVSSGWIKQGLVHQHGQVRIDALGLLCECHRSTELVTAEEMQLIHFFLRYNLNVQSPGLRQQISSLLGKLFCRIREGSQGLYKLVQNKARAGPAPESAQGNPDPKLAQEEPTEVLQRYQGFLSSVCSRLFEALFPGSSHATRFSALTILSSLAEMFPASDGDAPVVFQLAKEMNPERVQTLLECFASTFEEVKTLAFDLLMKFPKNVTGWFHWKLQVLFQAAMELSTSTKPYDCVTASYMLNFLVHQEALLPAMCPPLPAPPGLPQDHRGSLAGTMEHNSLAVAGHLLDELEGDVSRAEESLLQAAALAPMYGRVHCLTGILQQMAPSSVTLLDTWKPVVARLLAAAYRLSAVVAPVVQSSSPEGLVPMDTDAAARLWMILSEIQPRDTNDYFHRAKLLGGQPGPQTEGGSADPAGDAPLDAPGKSRTACDVTAQTVLVCCWRSMKEVALLLGLLCQLHHGPCGPGSPDTLVTVQQVKEIGEYFRQPLLQARHRGAFELAYTGFGKLTEVLARCHHDGLHLLPEQWLWAVLEEIKSSDASSKLCATRRSAGIPFYIQALLAPGHKTGRMDLLKVAMQELISLAEPQPQPQSTIPQVHALNILRALFRDARLGESVGPYVAAGVRAAILGFTSPVWAVRNSSTLLFGALMTRIFGVKRGKDEHSKKNRMTGREFFSRFPALYPFLLEQLQAAATGSPRRSLGRTRVVHRYRVAFVHGGDVSLTTCPSPPGRCGRSPIYRSRELAARALVPFILTDQVPVTVGSLLDELPDCAHAPVRQNHIHGVLLQVSPSAGRATCTCHAGGSVCGESWVQTGKLWLGQRHNPCLVTRATFVDVLTLLTSCLRRSCPRSHLEPPGFREALDAVVSDSELATQALPGTAIPGLPQYLQSVARLALILPPPSDSTAAVQLLRSELSDLRLLGLEAMLSQERPRVPVEAAEALLRAALKERHPQCLSKLLHSLDLESWLPVAAHSLHLTAAQLWAWAMDIADLAAAGILLSVAPSCLASQNLVLGESPPAALGGSRVAGPGARPGPGGAGVAVGQECPQCGALLSRHQLLSRGSEDCGFLFPDLPTTLTLWRCVLTLLQSEEQAVREAAAQVVRVALAQEHICKTSELAFCPVTAAVALDVAIELLCELLLRWNRAATGVPVLLGWLLGDGETGPDAEPSLQEEEGILFDKGAANFWAETLTFSGHLGRHLSTLVAAIPARDLARLHGLRAAAAAEARTVSRLLQALPPVPTFSRTAEFTQLRVRAERAEGCLHVLSLAGRT
The following text describes a protein:
Function:
When phosphorylated, plays a role in filament reorganization.
Sequence:
MESMLRRQLSDRSLPGETTYAYSVTGGAGGHGTRISSTTMGSWSGRRYSGSGHDYHSVTGTGNLAIGNEKATMQHLNDRLASYLETVKKLEKENHTLEIKIKEVIDKKGPLEGKDYSKYNATITELRAKILDMCKGNAQLSIAVDNARLAAEDFKVKMEYELSMRQTVEADVARLRKILDETNVLRMHLEGDFESLKEELIVLKKNHEKDITELRTQITQAGVFVDVDAPKGQDLAKIMEEMRAKYEKIALKNQQEVKAWHESQMTEVQVQVTENTVALKEATSLMSETRRKHQALEIELQSALSLIEALKASLQDVEMRYSMELERYNGIIMRLQEELTKIRNEIQQSGREYELLLNIKVKLEAEIAEYRRLLEGGGELKLEDAVDKKKVQTKVVTITQTLVDGKLVSENKDVKSDEKIVIS
The following text describes a protein:
Function:
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MVLIRDVSSLLLLILGVICCICAVVGSLWTSQHGLPRRSSTGLQEDTSLGRGLGSIDNYQSTVFQTRQIEYRSRSCTCAYFTRCLLTLITVLLPIPIIFASQGLWKKFGDYIEQPRLQFNYRYLVLIESERGVRYATTLYNLESIPAFLPSSVSSQNLDHNGDGRPDEITLLISVPTNITYPSTLSLFLFFDTLLDYHDIIQTETVLHHRLPLSSPHSLFISSPVTLHQLAPLNPSMRFPRLLINDSDPSRMRSFPRDLMQVIANRPLGLRLERPIITPLSTTVLPNQFSIKLALTVPASRIAYQTRFFELIKWAWIQYLAIAVIIYWACEWIAAYLFENRLINAVIYRID
The following text describes a protein:
Function:
Monocarboxylate transporter selective for taurine. May associate with BSG/CD147 or EMB/GP70 ancillary proteins to mediate facilitative efflux or influx of taurine across the plasma membrane. The transport is pH- and sodium-independent. Rather low-affinity, is likely effective for taurine transport in tissues where taurine is present at high concentrations.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MTQKKSQLCSRANVYTQVPDGGWGWVVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSRISWIISICVFVLTFTAPLSTVLSTRFGHRLVVMAGGLLVSTGMVTASFSQKVYHMYLAIGIISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAMFAFAPAITALKETIGWRYSLLFVGLLQLNIIVCGAMLRPIVISGPGTPKATTHENRREVQYMLENEKTRTSIDSIDSGVELTTSPRNVPSHPGVEPEPKADLQQILGKPSSKQSDQKPPLLDFSVLREKSFICYAFFGLFVTLGFFAPSLYIIPLGLSLGIDQDRSAFLLSTMAIAEVFGRIGAGLVLNREPIRKIYIELVCVILLTVSLFAFTFATDFWGLMSCSIFFGAMVGTVGGTHIPLLAEDDVVGIEKMSSAAGVYVFFQSVAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMFLAALCLALVRPCKRGLCQRPRAHEGTAETHRGKALQDIPEDFLEMDLGKHEHKGHLKTEPV
The following text describes a protein:
Function:
Secreted alpha-galactosidase required for catabolic conversion of melibiose to glucose and galactose.
Subcellular Localization:
Endoplasmic reticulum lumen. Secreted.
Sequence:
MISISFLNCFFLVFLFLFFSDVHGSYNGLGLKPQMGWNSWNKYACDIDESIILNNAKAIKEEGLLDLGYEYIVMDDCWSKHERNATTGRLEANPDKFPNGIGSMAKKLHDMGFKFGMYSSAGKYTCAGFPGSLNHEQIDADTFADWGVDYLKYDNCFNEGKSGVPLISYERYKRMSDALNKTGRPIFYSLCQWGEDFVWNWGNTIANSWRISGDIFDTFSRKDVRCPCETIECFALQGDHCSVMNIISKASFLSSKAGMNSGWNDLDSLEVGNGGMSFEEYKTHFTMWAILKSPLILGNDVSSMSPMDKLIVSNKELISINQDIGTNPAALIWKKKYGDEYIELFSGRLSNNDWVVAVLNAASEPLKMGIHLSDIFVDALGNAEHDWLATDLWNNNVKLVSDRIRANVASHGVQVWRFQQYKVKNTNDKFFSFNKH
The following text describes a protein:
Function:
Nuclear genome-encoded factor required for the accumulation of photosystem I (PSI). Functions as a PSI biogenesis factor. Cooperates with PYG7 to promote the stable assembly of PSI in the thylakoid membrane. May target primarily the PsaC subunit. Does not seem to be required for the expression of chloroplast genes encoding PSI subunits.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein. Note=Associates with the stromal face of the thylakoid membrane.
Sequence:
MGALPVAHSLALTAAFLPCRRPAAHGRCRRRRYRAVVAYMEPNPNSPAAIAGRLVGALPIVGLVARILNDEGGVGGDIIDFAEFRRRVSKKCTVMDSKAFYDFNQRRGKPGDPFYVLLCCWLAAIGAGLLKTEEILEGVARLRISNDIEFEEETFIDMMRAAKEKRAKLKAPAPQIPMETRAEKALEAIYVCCFGQDMVEDEDEKLLRAILNAVFPSVGRAAVERMVASMAKQVASGERKRDGRTVSKEVQQRQLKDLEFLKQNKLESS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTTASATPQQMRDRLLQAIDSHSNICNMVAVLDVITNLEKYPITKEALEETRLGKLINDVRKKTKDEDLAKRAKKLLRNWQKLIEPGQGDTPVRGPPNVPGSANGGAHPCRTDTPPAVPPPSKVAPELKTRNDIHNTYSPKAEKSSSRKRRAEQRDSPHLPAKMSKTSLYEPVYSSSPPSNGIRGTPEPLLEKDDEVPSDRIRLEHLDNDRHNKIPVNAVKPHPSSPGLTKLPSTSSLLKASVLQQARVDSGGQHQPKSPRYSSSPRSATHETMAKRSTTYAPKGTLSSPSLNSAQVPSPLPTLQPLTSPAQVCISDGPSSVGLEGSLHLHRSSDRVSQPPHSTATLEPLSGALLATHGLEGLETKAEREGASSNSDGKKRKKYRPRDYTVNLQGQSSEDRTKPRLKERRLTFDPVTGQIKPLTPKESHQEEECHGQPIPEPSVRTDIPQQKPPTSVPNPFQQTNWKELSRNEIIQSYLNLQSNVLTSSGAQTHGAHFFMTEYLKREEHDVKEPRKMHVLAPGSSTTELPGVSRDVTNEDLLRIHNEHWPGVNGCYDTKGAWFDWTDCISLDPHGDESKLNILPYVCLD
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MQKQQSTLIKQSLPMICGILLDATFFVHNNRKLNVEEIREYVNIINSFIRVLKEIHDNSSIFIIVYAGKSVFVKESDRGELTISIAEAIKEVLNDKFLVNEPNLSSAMSLALTTINKDGKLQPDIQKKIIIVSTPFESSPKFIPLMNCVFAAQRIKTTIDTIVLSVIETRCTFCQQASYLTNGIYNTATLQSLFPRLLSNNTSDCDTEKIIRVTGNQQPAIDWKLWCFHCKKPLDHGYVCSSCFGIYCEKQKGRCPTCGAYFE
The following text describes a protein:
Function:
Facilitates a shift in the ensuing immunity toward the Th2 phenotype and could aid in immune evasion by mycobacteria. Interacts with human Toll-like receptor 2 (TLR2) and triggers functional maturation of human dendritic cells (DCs), leading to secretion of IL-4, IL-5 and IL-10 from CD4(+) T cells and induction of Th2 immune response. Maturation of DCs involves PI3K, ERK1/2, p38 MAPK and NF-kappa-B signaling pathways.
Subcellular Localization:
Cell membrane. Secreted, cell wall. Cell surface.
Sequence:
MNFSTLPPEINSALIFGGAGSEPMSAAAVAWDQLAMELASAAASFNSVTSGLVGESWLGPSSAAMAAAVAPYLGWLAAAAAQAQRSATQAAALVAEFEAVRAAMVQPALVAANRSDLVSLVFSNFFGQNAPAIAAIEAAYEQMWAIDVSVMSAYHAGASAVASALTPFTAPPQNLTDLPAQLAAAPAAVVTAAITSSKGVLANLSLGLANSGFGQMGAANLGILNLGSLNPGGNNFGLGNVGSNNVGLGNTGNGNIGFGNTGNGNIGFGLTGDNQQGFGGWNSGTGNIGLFNSGTGNIGIGNTGTGNFGIGNSGTSYNTGIGNTGQANTGFFNAGIANTGIGNTGNYNTGSFNLGSFNTGDFNTGSSNTGFFNPGNLNTGVGNTGNVNTGGFNSGNYSNGFFWRGDYQGLIGFSGTLTIPAAGLDLNGLGSVGPITIPSITIPEIGLGINSSGALVGPINVPPITVPAIGLGINSTGALVGPINIPPITLNSIGLELSAFQVINVGSISIPASPLAIGLFGVNPTVGSIGPGSISIQLGTPEIPAIPPFFPGFPPDYVTVSGQIGPITFLSGGYSLPAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGAIGPLTTPPITIPSIPLGIDVSGSLGPINIPIEIAGTPGFGNSTTTPSSGFFNSGTGGTSGFGNVGSGGSGFWNIAGNLGNSGFLNVGPLTSGILNFGNTVSGLYNTSTLGLATSAFHSGVGNTDSQLAGFMRNAAGGTLFNFGFANDGTLNLGNANLGDYNVGSGNVGSYNFGSGNIGNGSFGFGNIGSNNFGFGNVGSNNLGFANTGPGLTEALHNIGFGNIGGNNYGFANIGNGNIGFGNTGTGNIGIGLTGDNQVGFGALNSGSGNIGFFNSGNGNIGFFNSGNGNVGIGNSGNYNTGLGNVGNANTGLFNTGNVNTGIGNAGSYNTGSYNAGDTNTGDLNPGNANTGYLNLGDLNTGWGNIGDLNTGALISGSYSNGILWRGDYQGLIGYSDTLSIPAIPLSVEVNGGIGPIVVPDITIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVGPITVPGVPISRIPLTINIRIPVNITLNELPFNVAGIFTGYIGPIPLSTFVLGVTLAGGTLESGIQGFSVNPFGLNIPLSGATNAVTIPGFAINPFGLNVPLSGGTSPVTIPGFAINPFGLNVPLSGGTSPVTIPGFTIPGSPLNLTANGGLGPINIPINITSAPGFGNSTTTPSSGFFNSGDGSASGFGNVGPGISGLWNQVPNALQGGVSGIYNVGQLASGVANLGNTVSGFNNTSTVGHLTAAFNSGVNNIGQMLLGFFSPGAGP
The following text describes a protein:
Function:
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular Localization:
Cell membrane.
Sequence:
MKLVTSITVLLSLGIMGDAKTTQPNSMESNEEEPVHLPCNHSTISGTDYIHWYRQLPSQGPEYVIHGLTSNVNNRMASLAIAEDRKSSTLILHRATLRDAAVYYCILRD
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MAILETLDQTAPVSGSSTVVSPENFIKCLKKFYGRWKEDVSDLWGSSSAIAVATPPPSDNIRYRKSLALSMWFFGSEFADTIMVFLSSQIHFLSGQDGYDLLQHLKMPASKAGFDIVLHNLEKADNGSLLMDQILNSVFAQYESKNVVMGHIAREKPEGKVLEEWYQKLHGSRLKLYDVSSGISELLSVKDASEIMYVKKAAHLTASVMRKDVVPKLENIVMDEKKVPHSKLMDLTEKIMLSPSKISVKLKAGNVDICYPPIFQSGAKYDLRPGALSNDDDLYYDYGSLIVCAMGAKYSGYCSNVARTFLIDCSASKSYQAAVDVVREEAPDLLPFLTKSGGTGIGIEFRETWLSLNEKNDLIVKEGMVFNVSLGFQNLLAKSSDEKIEEISLWLADTVLICKEKPEVLTACISKAEDDAFYSFDEEKIGSPSKPAPKTEQMAPLKVKPMLKSDMMLSLKDNLRSSSRTPKEDLRRQLQSEILRKKTNETAMRSDGTNLNLLEGHGQFRAMSELVAYKNANDFPNVNQLEIQVDKQNEAVLLPIYGFMVPFHVCTVKKAEIRGDSLQANISLAFLKSVTLLSRDRRHAEEVVQSMKILQEGVLERAKRASLVSQEKLQLHDGLTRDRIQLLDLWIRPALSGRGRKVFGALVAHVNGFQYTVSKSEKVDIMFGNIKHAFFQPAERDMITLLHFHLYNEIMVGNKKTRDVQFYIEVMDAVDSISLKRRSAWDPDEIEEEQRERARRREMNRQFELFVRRVDSIWSKPRFNQLALQFESPLQKLGFNGVHGRTSCFIAPSPSCLVQLIETPFLVTSLREVDIVCLERVVLGQKSFDMVFVFQDYTKDVVRIEVIPMTDLDKIKDWLNDCGLKYYESKLNLNWRKVLKTMMNDPESETNNRWEFLNPDASDSDSESSETEDDQYEPSDMETGSESDNEGSDSESVVNSGDDDGGSDEDDGGESWDEMERKARDANAEIGSESDSEDERQHRRVKAKAKSRSS
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MAASAAARDRFLTVYISSDDEDDDVAVIGASSSPEEVQIQQAILLSIDSSASPITIPSSSPGTSAAGSSRGSIPLRKGKRKLPLELPLFPVTPRGSLLKAAETHQVIDVDDDRLNQVIDLDGDGSLHQPIGLHQPIGLHQPIDLDAGGSGSIPIKEAGDGARGSRHDVPRELGGCSYILDGDDRREERGEEIIDGEFDCTICTETVPGIERFPIAGCAHAFCVGCVRQYIAAKVEENLLSIGCPDPGCKDGVLLPEECRHVIPPPLFQRWGAALCDMALGDLKFYCPFKDCSALLANDDPGDGDAAAAGAAVVTNVECPHCNRVFCAQCKVPWHDGVDCAEFQRLGDDERGREDLLLKKVAQEKKWQRCPKCKVYVERVAGCQFMVCRCGNWFCYLCGCTTPMNHVCRNCRPRRT
The following text describes a protein:
Function:
May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).
Sequence:
MDLGPGDAAGGGPLAPRPRRRRSLRRLFSRFLLALGSRSRPGDSPPRPQPGHCDGDGEGGFACAPGPVPAAPGSPGEERPPGPQPQLQLPAGDGARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPGRAEVTEQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVSEKLPPEATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPADEVILVELYPSGFQRSFFDEEDLNTIAEGDNVYAFQVPPSPSQGTLSAHPLGLSASPRLAAREGQRFSLSLHSESKVLILFCNLVGSGQQASRFGPPFLIREDRAVSWAQLQQSILSKVRHLMKSEAPVQNLGSLFSIRVVGLSVACSYLSPKDSRPLCHWAVDRVLHLRRPGGPPHVKLAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQKRNSIPPWSASSSMRGSTSSSLSDHWLLRLGSHAGSTRGSLLSWSSAPCPSLPQVPDSPIFTNSLCNQEKGGLEPRRLVRGVKGRSISMKAPTTSRAKQGPFKTMPLRWSFGSKEKPPGASVELVEYLESRRRPRSTSQSIVSLLTGTAGEDEKSASPRSNVALPANSEDGGRAIERGPAGVPCPSAQPNHCLAPGNSDGPNTARKLKENAGQDIKLPRKFDLPLTVMPSVEHEKPARPEGQKAMNWKESFQMGSKSSPPSPYMGFSGNSKDSRRGTSELDRPLQGTLTLLRSVFRKKENRRNERAEVSPQVPPVSLVSGGLSPAMDGQAPGSPPALRIPEGLARGLGSRLERDVWSAPSSLRLPRKASRAPRGSALGMSQRTVPGEQASYGTFQRVKYHTLSLGRKKTLPESSF
The following text describes a protein:
Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLWKRWTLAVTIVVLQLAAVLLFARGFLPSRVLLPGYTESRVSTEAPFQKAIIMVVDAFRSDFAFSDQSNCPQLHKRINSGGAIPFTAHSTPPTVTLPRIKGLTTGSTPNFLDAVLNIAESDNSSTLANQDSWLAQASRDGRKIHMFGDDTWIKLFPGMFDDCEGTASFFVSDYTEVDNNVTRHIDTQLDQKTEWDVLILHYLGLDHIGHKTGPESPFMPAKQKEMDDIFDKLYNSCDDDTVLILLGDHGMNEVGNHGGSSAGETSAAMVFASPKFETAQLTETAETSPLPWTDTYKYHSRMDQTDLVPTLTALLGLNTPKNNLGVLVSQMLGLWSPEDQLNVLKNNADQMVQILQGQASRESDAKEVYELYDTLNSNPSVKDYYNFLYEAQSYLTHASSNYNTNDMLGGIGLGLLSTILALTVFSALTLAVQGLKRLYLIILLVYFISVFGSSTVEEEHQIWYWITSGWMAFLYISGSRNKFGDGFNWMFVQVFVRMMISWNQTGQKFTKKDDIVTWLSKDGNHPVLWILILVTYGVAFNKVWRYGFSKVESKLAFLLTLITTFASVGFKITQAWEAGEVVPAPLLYLMGLPGTLNEVNARMAGLARFAFSTIAAGSLYRVLSLAGTDKVNLIRDLHAFLTLFLITQSRIQNIPLFMVYYFLEIFLRKATNRSFIFSSRDIYQTEALFQKLVLVLSVSTLLLEQVSFFSMGNSNSMASIDLSNAYNGVTLYQIEFVGVLTFVSNWIGPLYWSTAGLSFLLEDHVRNAIFAKIAEKNNDVKLTTKLVQQALTLRVYVVLAFSSVAISAVMITCFFLREHLFIWTVFSPKLLYQFVWTVLQFALVDVILSSIFVVLVYRSV
The following text describes a protein:
Function:
Mediates thiosulfate uptake.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MFSMILSGLICGALLGFVMQRGRFCLTGGFRDMYIVKNNRMFYALLIAISVQSVGVFALIQAGLLTYEAGAFPWLGTVIGGYIFGLGIVLAGGCATGTWYRAGEGLIGSWIALFTYMVMSAVMRSPHASGLNQTLQHYSTEHNSIAETFNLSVWPLVAVLLVITLWVVMKELKKPKLKVATLPPRRTGIAHILFEKRWHPFVTAVLIGLIALLAWPLSEATGRMFGLGITSPTANILQFLVAGDMKYINWGVFLVLGIFVGSFIAAKASREFRVRAADAQTTLRSGLGGVLMGFGASIAGGCSIGNGLVMTAMMTWQGWIGLVFMILGVWTASWLVYVRPQRKARLATAAAN
The following text describes a protein:
Function:
Catalyzes the conversion of deoxyribose 1-phosphate to deoxyribose 5-phosphate. Also shows weak activity with glucose 1-phosphate and mannose 1-phosphate. Could be involved in pentose biosynthesis.
Sequence:
MRLFGTAGIRGTLWEKVTPELAMKVGMAVGTYKSGKALVGRDGRTSSVMLKNAMISGLLSTGMEVLDADLIPTPALAWGTRKLADAGVMITASHNPPTDNGVKVFNGDGTEFYVEQERGLEEIIFSGNFRKARWDEIKPVRNVEVIPDYINAVLDFVGHETNLKVLYDGANGAGSLVAPYLLREMGAKVLSVNAHVDGHFPGRKPEPRYENIAYLGKLVRELGVDLAIAQDGDADRIAVFDEKGNYVDEDTVIALFAKLYVEEHGGGTVVVSIDTGSRIDAVVERAGGRVVRIPLGQPHDGIKRYKAIFAAEPWKLVHPKFGPWIDPFVTMGLLIKLIDENGPLSELVKEIPTYYLKKANVLCPDEYKAEVVRRAAEEVERKLSSEIKEVLTISGFRIALNDGSWILIRPSGTEPKIRVVAEAPTEKRRDELFEMAYSTVSRIVKEAEKK
The following text describes a protein:
Function:
Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Together with NdufAF3, involved in biogenesis of complex 1 modules N, Q and P-peripheral, but not the P-distal module. Required for recruitment of the complex I assembly factor Timmdc1 to complex 1 assembly intermediates.
Sequence:
MGQVVSMVARRANRFNVENRAHRVLEREKPTPAPKFDSNLRDMERTLELDPKFVDKLNMKDSSLDGRLKDVYVTSQDRFIKRVQERQAAEAAADNVEQRPLPLERKTPDDFEYGYLEPNRISPGHCTLRQALKFINDHQLDPESWPAKKIANEYKLKEPLVENILHYFKTFNMYIPDQKYKDTMLTQATQPLLRVKSSSEGNP
The following text describes a protein:
Function:
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Sequence:
MSYRATKHGFAAEAQKKVTAKHNPEQEKEVLDWIETVIGESLSGSSAKEKLKDGIALCKLINKLQPGSVAKINESKMAFKQMENISKFLAAIGKYGVSVTDTFQTVDLYEGQNMVQVICTIEALGRQKNNFTGPTIGVKIATENKREFTEEQLAAGQTVTSLQMGSNKGATASGINFGNTRHM
The following text describes a protein:
Function:
May be involved in maturation of the 30S ribosomal subunit.
Sequence:
MATVYDVPGDLLVERVAKALKEVPEIKPPEWAPFVKTGRHKERLPEQEDWWYYRVASVFRKVYIDGPVGIERLRTWYGGRKNRGHAPEHFYKAGGSIIRKALQQLEAAGFVQKVPGEGRIVTPKGQSFLDKIATELKKELEEQIPELKKY
The following text describes a protein:
Function:
Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as corticosterone, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as 11-dehydrocorticosterone, in the presence of NAD(+). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure. Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen (By similarity). Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone (By similarity). Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro (By similarity). 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as a ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity).
Subcellular Localization:
Microsome. Endoplasmic reticulum.
Sequence:
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNGPGALELRARCSPRLKLLQMDLTKPEDISRVLEITKAHTASTGLWGLVNNAGLNMVVADVELSPVVTFRECMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFSCELLPWGIKVSIIQPGCFKTEAVTNVNLWEKRKQLLLANLPRELLQAYGEDYIEHLHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYTGRGLGLMYFIHHYLPGGLRRRFLQNFFISHLLPRALRPGQPGPVHDTTQDPNPSPTVSAL