lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular Localization:
Cytoplasm.
Sequence:
MAHENVWFSHPRNFGKGSRQCRHCSSHSGLIRKYGLDLCRQCFREKAADIGFNKYR
The following text describes a protein:
Function:
Initiates the restart of stalled replication forks, which reloads the replicative helicase on sites other than the origin of replication. Recognizes and binds to abandoned replication forks and remodels them to uncover a helicase loading site. Promotes assembly of the primosome at these replication forks.
Sequence:
MSVAHVALPVPLPRTFDYLLPEGGVAKAGCRVRVPFGKQQERVGIVVSISDHSELPLDELKSVIEILDNEPIFSPSIWRLLLWAADYYHHPLGDVLFHALPVLLRQGKPASNAPLWYWFATEEGQAVDINSLKRSAKQQQALAALRQGKIWRYQVAELDFTDATLQTLRRKGLCELASETPAFTDWRERYAVAGERLRLNTEQATAVGAIHSASDGFSAWLLAGVTGSGKTEVYLSVLENVLAQGKQALVMVPEIGLTPQTIARFRERFNAPVEVLHSGLNDSERLSAWLKAKNGEAAIVIGTRSSLFTPFKNLGVIVIDEEHDSSYKQQEGWRYHARDLAVYRAHSEQIPIILGSATPALETLCNVRQKKYRMLRLTRRAGNARPALQHVLDLKGQRLQAGLAPALIARMRQHLQADNQVILFLNRRGFAPALLCHDCGWIAECPRCDHYYTLHQAQHHLRCHHCDSQRPVPRQCPSCGSTHMLPVGLGTEQLEQVLAPFFPGVPISRIDRDTTSRKGALEQHLAEVHRGGARILIGTQMLAKGHHFPDVTLVALLDVDGALFSADFRSAERFAQLYTQVSGRAGRAGKQGEVVLQTHHPEHPLLQTLLYKGYDAFAEQALAERQTLQLPPWTSHVIIRAEDHNNQQAPVFLQQLRNLIQASPLSDDKLWILGPVPALAPKRGGRYRWQILLQHPSRIRLQHIISGTLALINTLPEARKVKWVLDVDPIEG
The following text describes a protein:
Function:
Golgi membrane protein involved in vesicular trafficking.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MDQNQPPGENYAHPKICFFHVLFKAASLAFYILSTIFVDSFVIIFVVTVLLAALDFWVVKNVSGRILVGLRWWNEINDLGESVWRFECLDQESLARMNKKDSWLFWWTLYLAAVVWILLGIFSLVRFQADYLLVVGVCLTLSLANIIGFTKCRKDAKKQIQAFASQTIASRVSSTLQSAFSVV
The following text describes a protein:
Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.
Sequence:
MIAHKQKKTKKKRAWASGQLSTDVTASEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLLYLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEVNEENKNDVFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESVDSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGALAKNLNKQLEKKRRLEEEALQKVEEASELYKVCVTNVEERRNDLENTKREILTQLRTLVFQCDLTLKAVTVNLFNMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEDKVDGNVNKHLNSSQTSEFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPSSPSETGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQKLPGKIQLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQEAKKDSLEDKKWPNMCIEINRILLKIKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITHSQKIFDGALQPQDVMCSTGVFSPQVDQGCFPKPLLSPEERDPERSMKSLFFPSKEDIHTSESESKIFERPTSFEESERKQNALEKWDACLSDKAQLLLDQEVESASQKTEDGKTPKPLSLKSDRSSTNCVERHTPRTKIRPVSLPIDRLLLASPPKERNGRNMGNVNLDKFCKNPAFEGVNRKDTATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTMIVPSALQEKGVTTSLQISGDHSVNATQPSKPYTEPVRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPAISIRGNEEKPASPSAAVPPGTAHDPQGLMVKSRPDPDKASACPGQATGQPKEDSEELGLPDVNPTCQRPKLKRMQQFEDLEDEIPQFV
The following text describes a protein:
Function:
Promotes the exchange of Ras-bound GDP by GTP.
Sequence:
MTTNSKSLNLLQSLTCGICQNLFKDPNTLIPCGHAFCLDCLTTNASIKNCIQCKVEYTTYIPNHPLKQMIDCLDQSSNNNNSNNNSNGENTNNNNNIINNERSSFNGSNSNSIIGFIEGLSDSTSNGRRFSQQDGLRYSSGLLDGSNSGGSNNIRYCMEHYEHYYAFCNDCQAPVCPSCLLTTHNRHGMIPLTKDSIATKMKEYRDIVQSFKTKMSQYKDNITLYQKEIELLDSTFLQCKQSIQLMISNLHKVLKSRETYLLKEISSIHYASHMELTDRSSTLENEISEMEKLIGNGTDKFKDATEILNNQNLKFEFLEQFHHSRTQSKKNQNQDGLKPLFKTDLLFYKANNERVTEMINGTLGNISLLTFPLDDIGEVNIWDEPKENICIEKVRTNSNGIEEFEVKYGSLNKLIERLCLPNCYDDNYVNIFLLTYHSFCSSKKLLKKLIERFTIPEDLEAHGLTLASIHEIHMKIRSVLVKWINEYSPKFDQDTIHLFQNFNCRMQSEYTSIQEIENLLLNSNENSPSITSSQSLSSQSLYSQTNNNNNNNNNNSNNLQPTIQTNQTLSSNINNITISNLNNSNLTNNGTCKIQNSPPKNYQQSNYSSIFNGPSSSSSSSPSSPILSLNSLALINGNDNLVFESPLNSPRNNNNNNNNNSPRSSSFGASSALKFNSNNNSLNINSNMGGPYFPSPSSPTTNNIPNINHFSSRILSSSKNLEFNDIDEFEIAKQLTLIEFENFGRIKPIDLLTCVDLKHKTPHITNIMERFHNISTWVSTTIVRGENLKNRVKIVNKFIKIAEHLKNLNNFNSLTAILVAIQRSTVTKKDLVKQSVKIITDLEKLMSSDDSYSTYRTRLAQCSPPCVPYISIYLQDIMDLEKKNPSNIIVQTSSNKTQEFINFTRRSLISKVILDLASYQRFGYSTILPISNIQEYLNVHIDEL
The following text describes a protein:
Function:
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
Subcellular Localization:
Cytoplasm.
Sequence:
MERIIMHYDMDAFYASIEINRNPKLKNKPLVVGENIVTTASYEARKYDIHSAMKVSDAKLLCPKLIVLPVDKTEYIRISNEIHNLILKITNKVEFVATDEGYIDLTDVIKPENKKAFVIKFKQRIKELTNLTCSVGIGFNKLSAKIASDINKPFGFFIFENEEEFIKHISDKKIKIIPGVGKKFFEILKNDKIFYVKDIFKYPLDYLVKKYGKSRGENLYCSVRGIDFDEVEYQREIYSIGNEETFLIPLQNNSEIIREFNSLFEYTFERLLKNNVFTQSITIKMRYTSFKTYTKSKKLKFSTRSKDFLYNEMFELINSFEKEDEVRLLGVYFGDIKKSNLVQLALNKNL
The following text describes a protein:
Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins which inhibit adenylate cyclase.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDFHKAPPPRPPSLATALSKANDVYDYIFIDSGSPDSYLSADVGSIGNETFFNESANAFANTTDLGPVPASINGTADEPLADVIVMAITSLVLGLMILVTVIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISRGWILGPELCDIWTSCDVLCCTASILHLVAIATDRYWAVTNIDYIHSRTSRRVFTMIFLVWFASVIVSLAPQFGWKDPEYLQRIEQQKCMVSQNIAYQVFATCCTFYVPLFVILVLYWKIYQTARRRIHRRGPKIPATPNSSNQEETPKPKSKIRFHLKKKFTNPTKSAVSSLGLVEGNSTNTVNTVEDTEDSTANAADRKGLETTFSGDEGNGTPLGNNQIPTVSYEVTHQQLAQAAGCSESNNNNNPGRTGSAGKTSPSGNGGTLPGSTYPVQAVHASSPLLPPQHRHHNAATAAKQPAGTPTAHLTPGSAGSGLQGAGGGSTLNIASTPNPQAQVSKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFLTALLLPLCESCSINDTVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGTHRSANYRRGKL
The following text describes a protein:
Function:
Probable transcription factor that may participate in abscisic acid-regulated gene expression during seed development. May be required for seed maturation and dormancy induction.
Subcellular Localization:
Nucleus.
Sequence:
MDASAGSSAPHSHGNPGKQGGGGGGGGGRGKAPAAEIRGEAARDDVFFADDTFPLLPDFPCLSSPSSSTFSSSSSSNSSSAFTTAAGGGCGGEPSEPASAADGFGELADIDQLLDLASLSVPWEAEQPLFPDDVGMMIEDAMSGQPHQADDCTGDGDTKAVMEAAGGGDDAGDACMEGSDAPDDLPAFFMEWLTSNREYISADDLRSIRLRRSTIEAAAARLGGGRQGTMQLLKLILTWVQNHHLQKKRPRTAIDDGAASSDPQLPSPGANPGYEFPSGGQEMGSAAATSWMPYQAFTPPAAYGGDAMYPGAAGPFPFQQSCSKSSVVVSSQPFSPPTAAAAGDMHASGGGNMAWPQQFAPFPVSSTSSYTMPSVVPPPFTAGFPGQYSGGHAMCSPRLAGVEPSSTKEARKKRMARQRRLSCLQQQRSQQLNLSQIHISGHPQEPSPRAAHSAPVTPSSAGCRSWGIWPPAAQIIQNPLSNKPNPPPATSKQPKPSPEKPKPKPQAAATAGAESLQRSTASEKRQAKTDKNLRFLLQKVLKQSDVGSLGRIVLPKEAEVHLPELKTRDGVSIPMEDIGTSQVWNMRYRFWPNNKSRMYLLENTGDFVRSNELQEGDFIVIYSDIKSGKYLIRGVKVRRAAQEQGNSSGAVGKHKHGSPEKPGVSSNTKAAGAEDGTGGDDSAEAAAAAAAGKADGGGCKGKSPHGVRRSRQEAAAAASMSQMAVSI
The following text describes a protein:
Function:
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Sequence:
MPPLETAVTGYRRVNRWWRKIPPDEMAVARLPPDEMAVAPRLAAGSLPPISGRVPPILQVAGGSCHPSFRALCSLSSVVVVLTLAVVALITPAAIDRRKSISPSYYPLSPLLKVRRGLPPPRPRDYQSELATPSPAPLQIWRRRPPALMAIRVPSMELHRPAPLVSGGRGKTCLQKKPFLVQAKRLGGLEKASTRGAQESGQPKKRAPLIRGTVSPPLPVPGNIPRPPYVGTKDVPEIAKEIQMHDKEGIIHMRAACELAARVLEYAGTLVKPSVTTDEIDKAVHKMIIDAGAYPSPLGYGGFPKSVCTSVNECMCHGIPDSRALQDGDIINIDVTVYLNGYHGDTSKTFLCGEVDEASKRLVKVTEECLLRGISTCKHGTSFKKIGRRISEHAERHGLGVVECFVGHGVGRVFHSEPIIYHQRNNKPGQMVEGQTFTIGTQEGSQLILDSLFTTLAVKPASFGFHSRRHALCVPDCCRTFLSRADPIHGEHRLRHVGRRLDRRDDGRQLGRPVRAHHTHHQDRRRDPHEMLGENLLHAR
The following text describes a protein:
Function:
Involved in the regulation of vernalization; this process in essential for flowering in cv. Bd29-1 but seems do not occur in cv. Bd21.
Subcellular Localization:
Nucleus.
Sequence:
MSTCGMCAGSSYCPHHQRASWPAHDHRSPPPVEYHDFFHHSVQGQAAAWLRLDNPPLPQPAEHDQAAAGMIHGGHRHGTFELNRPLMDDQHLLQMPPPPTIMPFGGGTFGDTMGREAIMAVDGEMMMVAAHHPTMHEREAKVMRYREKKKRRRYEKQIRYESRKAYAEMRPRVKGRFAKVPGSAAPPSPPPSGPRIYIASCFKSNGTVIVQEVMHDLPI
The following text describes a protein:
Function:
May be involved in transcription termination by RNA polymerase III. Binds RNA and DNA. Binds to precursors of RNA polymerase III transcripts. May play a specialized role during fly development.
Subcellular Localization:
Nucleus.
Sequence:
MAEVAETPSVEAQEEVAQPAEAQVLEAKNGDAKKDPAPAAEEAAGGFTKQERAIIRQVEYYFGDANLNRDKFLREQIGKNEDGWVPLSVLVTFKRLASLSTDLSEIVAALNKSEEGLVEISEDKLSLRRHPERPIPEHNEERRKEIQERTAYAKGFPLDSQISELLDFAANYDKVVNLTMRKHYDKPTKSYKFKGSIFLTFETKDQAKAFLEQEKIVYKERELLRKWQVDYLKEKQEEYAQKNEKRKNKKEAKPEPAFELPKNAIVVFEGAPETSSREEIREAFEKIKDFEVAYIEFAKGETKGSVRLTEADAAEKYIAKVEEGKLKFKDEVSLSLRKATEEEEKEFIDKAIEFMKKRRDFTRNKGKRFNRKRHGGNDHKHGGGKKARGD
The following text describes a protein:
Function:
Stable protein which acts as an antagonist of nosA by repressing cellular differentiation after the tight-aggregate stage, when cells differentiate into two precursor cell types, prespore and prestalk cells, prior to the formation of fruiting bodies.
Sequence:
MVKINIKSSTDNKFDVDVELGITVADFKKVIATKCSIPADQQRIIYSGRILKDHQTLDEIKIQDGHTVHLVKGAAPPPPPPVEQQVPTPSNTQPQGIPGVPQNINDMMNNPMIQEMFNSRMMDSLLDNPDIFRDMMMGNPEMREVLNNNPEMAQMLSDPRQLRQSLEMMRNPELMREMMRNADRAMINIENHPEGFNLLRRMYTDIQEPLMNAANQQAASQNQTNSNPIQTNTDANPNSQPLPNPWSTNSSSTSSNPTSSSPSSRPTTGSSTNTGASNPWASMFSGGGGGMGGGTNNTGTNNTGSTNNTGASNPWASMFGGGGGGMGGMGGMEGMLGMDPERVQQLLNNPVAQQMMQRLMSDPAMMQQMITMNPQLRQMMDSNPQLREAMNNPEFLNMMTNPENMNAMMQLQQAMGTLRNNGVFPGGMGGMGGMGGMGGMGGMGGMDFSQFGNMFGGMGGMGGMGNNNSSTTRPPVNQEPPEQRFRLQLEQLEELGFVDRAANISALTSTNGNINLAIDRLLR
The following text describes a protein:
Function:
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. Required for proper inclusion of regulated exons in Ubx transcripts, leading to isoforms Ia/b and IIa/b.
Miscellaneous:
MISCELLANEOUS: [Isoform A]: Major; MISCELLANEOUS: [Isoform B]: Minor.
Subcellular Localization:
Nucleus.
Sequence:
MSVAAMTMDDQRPCMNSYDKMPPTKYEQNLNILNSSQNSGATGGPASPTPSGLEDHHHHHHPHPHHHHHQEQQQQQQQQQHLQQQQQQQQQQHAAAVAEAVAAAEQRQRLLEDEIENLKLEQVRMAQQCADAQRREKILMRRLANKEQEFQDYVSQIAEYKAQQAPTALALRTALLDPAVNLLFERLKKELKATKAKLEETQNELSAWKFTPDSNTGKRLMAKCRLLYQENEELGKMTSNGRLAKLETELAMQKSFSEEVKKSQSELDDFLQELDEDVEGMQSTILFLQQELKTTRDRIQTLEKENAQLKQAIKDEVVAPAAATNGGTNTTINKLETIHEDACMANNPTNPDCYNGNTNNEQIAAVPQIPLSDDGSNMNGNAARLARKRNYQEEEALPTVVVVPTPTPVGNNVQEAPPIREVTAPRTLPPKKSKLRGITTRRNSQLEEDHQPVTTPVAVPMIVDNAVAGMASEEAAAAAAAVNNSNTGIIPETGVQVGVPVEGGDPGAPAAPGRILTRRRSVRMQQNGSGAVDYST
The following text describes a protein:
Function:
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells; Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory. Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells; Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases. In complex with IL6, is required for induction of VEGF production. Plays a protective role during liver injury, being required for maintenance of tissue regeneration. 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGHPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPTQALATNKDDDNILFRDSANATSLPVQDSSSVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTWKLRALKEGKTSMHPPYSLGQLVPERPRPTPVLVPLISPPVSPSSLGSDNTSSHNRPDARDPRSPYDISNTDYFFPR
The following text describes a protein:
Function:
C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. CcoP subunit is required for transferring electrons from donor cytochrome c via its heme groups to CcoO subunit. From there, electrons are shuttled to the catalytic binuclear center of CcoN subunit where oxygen reduction takes place. The complex also functions as a proton pump.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTTFWSLYITALTVGTLIALLWLVFATRKGEAKGTTEKTMGHSYDGIEEYDNPLPKWWFMLYIGTIVFSVGYLVLYPGLGNWKGVLPGYEGGWTQDKQWEREMNIAQEKYGPIFAKYAAMPIEEVAKDEHAMKMGSRMFATYCSICHGSDAKGALGFPNLADNEWRWGGDPQSIETTILGGRHAIMAAWGDILGEDGVKNVAAYVRTELAGLKLPEGTKADVEAGKQIFSVNCVACHGPEGKGTALVGAPNLTNPGAFIYGSSYAQLQQTIRHGRQGQMPAQEPYLGKEKVHILAAYIYNLSHNQGSN
The following text describes a protein:
Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as an mRNA 3'-end-processing endonuclease (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MHHNNHHHGHHGRYQHHHNQHLKRPLKGGTEDDDILEITPIGSGSEVGRSCVLLKYKGKKVMFDCGVHPAYSGLVSLPFFDSIESDIPDIDLLLVSHFHLDHAAAVPYFVGKTKFKGRVFMTHPTKAIYGMLLSDYVKVSNITRDDDMLFDKSDLDRSLEKIEKVRYRQKVEHNGIKVTCFNAGHVLGAAMFMIEIAGVKILYTGDFSRQEDRHLMGAETPPVKVDVLIIESTYGVQVHEPRLEREKRFTSSVHQVVERNGKCLIPVFALGRAQELLLILDEYWIANPQLHHVPIYYASALAKKCMGVYRTYINMMNDRVRAQFDVSNPFEFKHIKNIKGIESFDDRGPCVFMASPGMLQSGLSRQLFERWCSDKRNGIVIPGYSVEGTLAKHIMSEPAEITRLDNVNVPLNLTVSYVSFSAHSDFLQTSEFIQEIQPPHVVLVHGDANEMSRLRQSLVAKFKTINVLTPKNAMSVALEFRPEKVAKTLGSIITNPPKQNDIIQGILVTKDFTHHILSASDIHNYTNLKTNIIKQKLTLPFAQTYHILISTLEQIYEQIIESTESTGGGGNEKPTITIYNEIKLIYNIGVSIILEWNSNTVNDMICDSIIALISQIELNPLSIKVRNPNFNNIDEKEEITKDDIEKEKEKEKEQQDGDDDDDDEIQIKVVSRKSRKLSNKLNTITEVKLLLEQQYGNFKVDENDPLILHFNLDNQKAIIHLETLTVESLDQILKQKIENSIKRIILSVSPIGNNLNQINNQDNENNIKMETDFK
The following text describes a protein:
Function:
GalNAc-specific agglutinin. Behaves as a type-2 ribosome-inactivating protein. Inhibits mammalian ribosomes. The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA (Probable). The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity) (Probable). Involved in plant defense against insects (By similarity). Has very low cytotoxic activity against the human tumor cell lines CEM and Molt4.
Domain:
The B-chain consists of six tandemly repeated subdomains. Only subdomains 1-alpha and 2-gamma possess a functional carbohydrate-binding site.
Sequence:
MRVVAGILYIVVMAICGLGIQGGTLQDYPSVYFQDSTLQQDFPTIFFNILAGETYGDFIADLREIVTRTADTKNGSIPVLLNPAHPVPVRERFVKVHLTGRNGKTVILALDVTNLYVAAFSANNVAYFFRDFSALERENLFSGMLTIRLSFTSNYVSLEHKAGVGRENISLGPTPLDEACTKSLWSGTTVTEASIAKALLVVIQMVSEAARFRHIEERVRRSFTAADHDQLTFRPDGLMLSMENEWPSMSLEVQRSIEGGIFIGVVQLQDESFQPLRVDNFNTLSRYTMVALLLFRCGHPRATAGTSSTTPAAAQIIRMPVDVLAGEEYYDEETCTVGEPTRRISGLDGLCMDVRNESNNDGIPIQLWPCGAQRNQQWTFHTDGTIQSMGKCMTSNGYHPGDYVMIFNCSTAPVPDATKWVVSIDGSITNPHSGLVLTAPQAAQTTILLVVRNTHSAKQGRSVGDDVEPIVTYIVGFKYMCLQGNNENNTRVWLEDCAVDRPQQWWALYSDGTIRVDSDRSLCVTSDGHSSRDAIIILTCDGGINQRLVFNTDGTILNPNAQLVMDVRQSNVALRQIILYQPTGNPNQQWMTMITRTRPSLTS
The following text describes a protein:
Function:
Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MKPLTLRLNNDGGVEIGIIRISAPDHTLNVVVPIGTDFHSPTTILETNHPSKTAKTQTISQSKDYSCMEDIVFSIPLTIPGAFVLKLKNATNVGPAVHFIVDPVITINNKKVPASGLNIQTNYGRCIGTLDKWLENLTPISKIGYNMIHLPPFQELGHHSHYSIKDQLQISKYLLPKGFDKSKAWNLFTKTVKEIESKLNIVFMVDIVLNHTNQDSPRLSDHPEAGYNEENSPHLIPAIYLDNLLNELSNEIAAGKVENLPPDLPASKRDELYNFLRKRILESDFARFFTIDEKKAIETLANSDDSNLTKSMEMLRMRSLNYGSPQRLNILRTRGVINEGTYKMDSIHIDNSYAMALFKFPGRTDESRLHEFELAIKTINAPFVQHFENLVNDVVTAIVNGFCYNRYDPNGPKLGPITVKTPISWRYFTPITAFKGTKQEKLLHLANNGWLFGAKPTEDFISKNSEAYLRRQVVIWGDCVKLRYGDKPEDNPWLWSYMQKYVESVARVTHGIRLDNAHSTPLNVAEYFIQKARDVNPSLYIMAELFTGGEDEDIKYINHIGINSILREAFHNLAPDKLSHMLWLSGGRPVAAIDPLDTESILRPLRQIPGVIFDLTHDNPTPYFDRLSAAAAITMASSPIATTRGFDEYLNFNPSVVEEFRIYPHTDKPVGIQAARLFFNELHTKMAVNGLDELMAHYHGNLLSLFRYNSHTGVGVWMVTRTSNDNWVNELECLAPIKNLIFEARTASVKYNDSTEEEIIPGDVDVEINTNFKKMKFCEIRNNSHLVLNDFPVGAVVAFSTQLPQPQLQLLKDLEVRKLADDLVKWTSQLSFADLSILMFRCGAEEGAQIGTGSYSFPQYGPCFYAGTQGILTAFDSSKDMGSPIFQNMRDGNWLCDFMIKRLYQAPHLIPILNFMRGKLDKIITLPRFTIPKYIDRLIRALDIFGREQLVRNMSNFVKNGDDFVQSLAFSSVALYGPVRDAPLINSTLSKIFDDTLVERQDCCLAAGLPHFSSGYMRSWGRDTFISLRGIFMTTGRFTEARDHLIAFGACLRHGLIPNLHDSCLNPRYNARDATWWFLQALQDYALMAPDGKEVFTWKVPQLFPTDDQQQFERRWAGKQTRPIRTMADVVMDIMTRHANGIHFVEWNAGTKIDSVMVEHGFHINIVTDWSNGFILGGNCDNCGTWMDKMGSSTWAKNSGVPSTPRDGAAIEIIGLLASTLRWLSEENKAGRFPYDGVNVEESGKKITFNEWHSILAANFESWFYIPADASEDDKYFIEHSFVSVRGIYKDTVGASNEFGDYQFRPNVPIAMTVAPELFDPRHAIHCLNLVEERLMGKIAMKTLDSADWRYNPYYENSVDNDNFYSAKGANYHNGPEWVWPTGYFFRASMKMSRGVTPGMTKMLANIKSYLLNSWAKGLPELTNLNGAVCNDSCVTQAWSIAAILDILYDHNGYSKEDVTKWSAAERLD
The following text describes a protein:
Function:
Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns; [Isoform a]: Mediates the response to LPS and Gram-negative bacteria; [Isoform x]: Mediates the response to LPS, peptidoglycan and Gram-negative bacteria.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MPFSNETEMSQCSNAKRRVNDPLTGPKNCSTSSTDSGVILNDNVAAFRPEKETKDRGTGEGQFQSKSEEKTESKRISVEHTVNITTENVGKTSSPAVSIRSTTISVVSIDDNAIDSSSIDSDSEAEAEDYTVQKLGHQVTYPPNSSHLRDLNQGLTVISRHVAPGEAAVPPPNPLEAGIVAKQILNGNLAVATPTSPAGGATQGIGSIALTNSTDVTFGDKHFYEGPVTIQQFLIDNRDKWKPGEGPAGGQDNPAFNGGPSTNGSAPGSKHEDPAQTPPICPFLPNTVGRKAVTVTVVFVTLTFLLGIVLATTTNLFGKTLNQSKIRDDDDYRQNIPINSTIDLDNIGGGLILRFVERQQWLAQPPQKEIPDLELPVGLVIALPTNSENCSTQAICVLRVRLLQTYDIESSQKCDIAYNFLIGGDGNVYVGRGWNKMGAHMNNINYDSQSLSFAYIGSFKTIQPSAKQLSVTRLLLERGVKLGKIAPSYRFTASSKLMPSVTDFKADALYASFANWTHWS
The following text describes a protein:
Function:
Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan; Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
Sequence:
MSGTSDLLLRAASQLEGDVSTNEVPMTFEVAWEVCNKVGGIHTVIKTKVPQTVAEVGERNYVCVGPFFPQARTDVEELEPKSEVLAATLDAVRSQGLQLVYGRWLIEGAPQVLLVDIEASRHRIDEWKKDLWEQTGIGCPWDDKESNNAIIFGYLVAWFMGEYLHQSEVLRGSHQQCVVAHFHEWLAGVGLILCRIRKFRLATIFTTHATLLGRYLCADPKCDFYNNLPYFDVDKEAGDRQIYHRYCIERGSCHSAHIFTTVSKITAYEARHLLKREAEVITPNGLNVVKFSALHEFQNLHAKSKAKIHQFVKGHFYGHITDEWDLDKTLYFFTAGRYEFVNKGCDLYLESLARLNHMLRQTGSDVTVVAFVIMPAKTANFNVEALRGQAVVKNLTDTVKTIQGKVGAKMLEQVMRGELPQSGELLDQTDVLKLKRGLLGAQRDSLPPVITHNLEDDSKDEVLGCIRRFVRHGKRRREPWGYTPAECTVLGVPSVTSDLSGFGLFLREHVEDPSQYGIYVIDRRFKAPEESIQQLTEHMFDFCCLNRRQRINLRNRTERLSDLLGWSTLQDYYYMARVKALHRVFPHQYPDPDAKSNTNFKLRASAANSPKLPRLEPRLEEDQVPMDQLSLE
The following text describes a protein:
Function:
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MQWYTGNITEAISLCKSQNSLFIVLVEAAAEDESAGSVWNDPEVQKLFADNNQYVALKLKSDSELAKQFTQIYPVFIHPTLYFIGRHGQPLEVKVGPLNATNLAQSARRAFDLHDVSLHPMTAPTTSSTTSTSTVLPSMSTATNTSNQPSSTDATTTNSNTATAAVTATTTVTSSSTTTSTKAVESTSSPVGTILVDEAVGGNESSSLEGKKDEHLTLEEKTEKTKLLIAEKQAAKAKLEAEKERQKELERRKLGQDLNKLKDLKSEMERKELEKELKGRKEADRLAREQIRRQLQLDREDRARKYYNEKEEETNQQIQKENEKTAAEKEKLERERVAKLTVARIQFRFPDGSSKVQQFNSSELLSVAHSFALQSMPGSVKNVSLSTIHPRKLFQAEDYDQTFLHHNLAPSAVLVVLPTTSASSFVSSSSSQRTTAVAGSGSGNFIYHVWIQIVSFLQYLLSFLLPFSSSSTTTTTTPVVVDGGGGGSSTHTAHHPPTTVHSEPLSSSSSSPVAYGGARPKTTNTDGLKKRKEGNIHRLTAADEEDDEQATWNGNSTQQM
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
MMENVAPEDGVEMLEHDISSGAVSKGDRSKGEVSKADLKASGGAGKAVRIACSFWLEKKKRFCTNQSKPGHRFCGNHVPEEALGFKRVPCPVDPSHTVPEFEVAAHVLRCPAAKQAQGVREQPYFREGVNAGSDAENGSHDGAGGVLTSREKRALLEGLSESEFWGFLEKIETAYASTCPEPLVRRVAQPEGFRRWLEGGKDSSSPFSAKHWEQQASILGNMDRAGLIDRPRPGDAERAATKGTTSSGPPTETRADLRIEEDLAEPVLEEERANGLLREAGSGREAVINSPDTLHRNTPTREDGSSSNGVPDGLAGTDASTVNKPPGRVFIEFGAGRGYLANALYECFGQPDVLFVERRAYKFKADRALRKVGKMERIRIDIEDLDLAGVESLRGRGFVGAGKHLCGPATDATLRCCLGSGDGNGNGPGDGIGKERTGRSGGDETASKGRGESGNETKSVGKGARANGLSADVSNDATGEKRATSIPTSGPDLRSEVDASREAPFCSGVAVATCCHHLCSWRTYVNKAFFRRLGFSPADFHMLTWLTSWCVSGPKFGEHRGPDAGNIDELSSPVGRSVDGSDRLKGNGASSMSMGEGSRTQTNEKSDLGSKTARKEGSLASDNARESSEVNGASNGSVTLQPPIWDALLPSQRAELGKKCKRLIDTGRLEWLAEQEGFAAELIEYIDAEVSPENRLLVATRTRNVL
The following text describes a protein:
Function:
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
Sequence:
MDKIFLHGMKADTLIGVYGWERERLQTLIVDLDIGVPEKAGSDDDIANTVHYAEVCETLRRHLKEQDFLLLEALAEYIADLVLGYFGAVWVRVKIVKPGILEGVREVGVEIERGKRED