lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription; E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAKGAPKGKSSASSATRKKQANKAAKKVAYERDEDGNLLHPELAEALEKQKQHGLQRGQKKDKSNKDGKGGKKSKAEKKKQYVPPPKPPQPLPDPLDSMGLASLLPADLVVLLRKASKKDVITRCRALEGLLTWVEDALGKSTSSAASEPNVDTSSLSLEQKRDALVMMLPSWVHLFPRLALSPTRRLRLLTMQIHILLLEKPQASSNGISSTREELLESPQYIEPILGPWAILCHDTDRSIERLGRLAWTDTCTWNDKQSADPFVERDSTVQLNLTEYCDTLVAHLRTILLSPSPSFTLSMTSAHAVASGDPSLSRNSSGYATPSLQVGGIERDAKNRDESNVEEDTPALDKRLVAGALSVLSSILRQKSDAEFEQSLQDIFSSRLVWASLSPHNLAASSAPRSETATAITSFGFDSPSVRLRAWTLLRTLFEVTPNVLEQHINTIGMVAMSSVWFERDNAVQRSTLDAILPLLKKHPELWLIGEKSNERGKRSKADSSDDDDDNDHDENESENDDENNDSSDTRSDDRDMDAQDPIQESSPKPRSYTSFLQWLQSACGGAPHLGYSSVVVFISTIPPELLAYDNLDSASDLLTNFFSALYSRPLDFDPVGCRAFFTSFTECVTFMALRMSRAGPSNGKGNAAFAKELVRVHFGAVWSELVLPKASLLTSLDIGSVEEDTDEAGRAQRIKNIGSTRIVSDLAVQVRRIAASTSELNVAGPFLAETEVDLVEMTQALCNAQARDAKVLAALERVTSFYAALSPAQSQAADAELRRVAASSIGQAIKLAASGLADIGAQDSTPSDLKRLRTTLLCDFLCVALRATVSASGALDTSVTQVLTKVSALSIPQLMATRCVAPNSAAAFLAAYLPLCPDEQARASIWTETLSSVALLAELRDRVDALSELFLASEAVAKAAFANNAKELQLPQPAPEAGIEDLAIGLVTSLCDSAGAPSELRCRLREVISNILTKPGSFVDTSCVEAMLSIVCSTIEQLRNTLLERPRSDEDSLLRRRVAATTQDLLHVLDCWIKAQASKADVRRTLKAPSFTGVLVAVSELVHLYHDCGDPSASPNDWVSKAYPSEVRALAFSVLQHVFEGSSEQELKEMRKQEMASLQDHLLDIHVPVIRLVNAAGYEASPLPEPLELREMLLKSCRQTTHPALMVFDPLVPHQRTSEKPSATSDSLVDGQGLGIFARVCAAALLILDQDRAEAKKLVHLLPYVILLSIFIEDDLLLPGSSKHALDSSVLPEAHRAWLQSSVTAATALISSLSYSVTENWHNDMVMTLQRSSVIDAEKDGIGHVLTAVWKMSSEAHVPSSYLARVFHRLLNAAFSFGTVTEAGADRWLKLGDAVQDRMPAMASAIFHAAKPIAGSSPIYERLRNGAAAKLAALGSNTAGDSILHSLRTLVALAPPVDSGLALIPQQRAMMLLKDLQKWYTDEENSGDAEEETSTRLAELFVHLLPVVQDVQGSHIDFIFDTLETNLEFCSLAEDDTVAQLYHNLRLLETMCDLASTNANLREYWKNRSVASVDLVRDQFLSLAGVQSISAPKQACVDVIVELIRETSEAPFKLQETAGALSKLLVQSPSHEVQVISYRLLSGAIREHVKELVVESAVDRESLATEEGQRKLKLPEALVANVGDNLGTQLNVLVEEGAARRTAFGYFLSWIAVFDHFEGASLWVKSAFLSEIEKRDLLVESLLPSVFALVGLADESRRGFDPSRFVLEEVFLDQIDAESSLTVLQVLAAHVYLRALIHMPTTVRSWWIDIKDRQHSMQIASFTTRYVSPIIAKRELSHLREPEALSKLQDEALSIKILSTNEVIATYVVDEHPMEIGVKIPADFPLHGVEIRDIQRVGITEAKWRSWLLAVQQLITGQNGLIFDALSLFKRNAEVQFQGLDECAICYSIISPMDRSLPTKPCKTCKNKFHAGCLFKWISTSGASTCPLCRSIL
The following text describes a protein:
Function:
Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLQTGRRCFSVLARCQPIATSSARAYSTEKAQKMEKKEIFELDGRQYTPDALYNLSPAVRRLLDRRILQETSNPLNLLKRRVVDYVHQTYRKPGNRSPLFTICESEPRVVTTYQNFDSLLTPEDHVSRRPSDTYYVNREHCLRAHTSAHQHTLMKQGLDVFLVIGDVYRRDEVDRTHYPCFHQIEGVRLYTRDELLGKKSDASENAAELFTVTRDASRIPEKQETHSLDAVKAAEIQLKQFLESLCDELFGRDADKRWVDAYFPFTHPSWELEVFYNGQWLEVLGCGIMEQKLLESAGVTDKIGWAFGIGLERIAMVLYGIPDIRLFWSKDTGFLSQFAGKQPGEDVKYKQISAHPQVIFDISFFLPDSTEFNDMTSDVYDTIRTIGGELVEQVKLTDEFENKKKAKKSQTYRIVYRSHEKALTKEEVNVIHKQIEQSLSTTYGVVLR
The following text describes a protein:
Function:
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity.
Sequence:
MSDEEEVYSDEEVEEEEVEETEEAPAEAEEPEETTEEVVAPPEVKERRAPVQEEKPPAEMTEAEIAMLAAKKRHEEEEAAKLLDYEQRRVLEKEQIEQELRELKEKQEKRRAEREEDERQFAERRRQDDERRRKEEDERKAKADAEKIRKNEEKVRRQQMMAGAFNGRVEAGAGRNFTVASKGDQAAQFGNLAQAKGGKDVMSKEQMEDAKRNFLAAVCRVQDVSGLLPNDLKERIRGLHARIVKLEAEKYDLEKRRERQDYDMKELHERQRQAARNKALKKGLDPEEAASSVHPPKITTASKFDRQTDRRSYGDRRYLFENPEEEKQASLVRGTGRPPAEWGRKQNEELEQIRKNLEPPKYVEQVKVEGARAPVEPVPLFVPTDDFEPQQVTEDPNVGEEVVVE
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MKIRSIERNCTLAWSPANQDVLLALGTVSGALDASFSSSTELELFDINIAGTALTPNGTTATTSKSMRKVGSVPMNARFNRLAWGAPGTQGTLKNGLIAAGKENGELDLLNPHLILDGKSDKESLIARHTTHGGPVRGLDFNPLHKNLLASGASDGEISIWDLNTVKSYAPGARSQRLDNVTALSWNRQVPHILASASNSGYTVVWDLRNRKEIIQLSYPGGRKPVTSLAWNPDTPMQMVTAVDDDMNSMLLMWDLRNASAPERTFSGHSKGILSVAWCPKDSELLLSCGKDNRTIVWNTVQGEPIGDLNHSANWTFDAQWCPKNPDLIAVASFDGCVTIHSLQSIASEEPDFQDNTVPSESHIDDDPFAQVSRQQTLNDPDAPVFVLRHPPKWLCQPAGATFGFGNRLVRTKPAQGKSVVSIHTVHSDAEISQRIDLLSRAFQSGSYEELVQYCDTLSSPETGFTLSEKDREVFKFFKAMVSSTSRDDIVQMLGFDKNLIADERLSGLFKRLNVKPVLPTDEQSVTNEDGSIATKSGSKSTATPFSLFAIGKPTEDSDIDTLITKALMLSDFETAVNICLGANRLADALVLAVSGGEELLYRTQQEYFRRTSKFKPYSRILQGIVDGDLMDVVENARVDGLGGGSWKDLVALVCTYAKNDDFSKLMGMIGSRLETTGSSLALTGTHTTMPSISGIKRSPMLTASDRERNHAAILCYIGAGNFDKVVGVWCQNEPADVTKPPPVTGLSTRLPSPTHASAVKSAASPKLALQTLIEKIFILSSVVQFVDPELNGLMDGQTEYALAPLYAKYLDYASMAAHAGNIECAWRILELVPNAFTTTPAPHASFENNQAGDDNGFDTLATAQADQVVSTDPVAILRDLVYQSGGYRIHQVGSAPAFPFSPFELAKPYEEPVYTQQPANSYNYGGQSNQNQFNIGNAWAQPSVPHTSRQPSFGGYQPQQQAPTPPVAMQPSMYGGAGFQPQQQQQNTWNHSNQQSYGGNSAYGGYQGQPSFQQQQQAPSVGVPSFQPAYARSTSVPPQSNPYAPMQTMQQQPPMSRTSSVLSPPITTPAVPAKHPVGDRSHIPEGQKPCFKILQHHLDDFKDSVHVGATGSADPHLMNSYRDAEKRLGQLFDQMNNTEVPQDVAEKLLQIGKALDKSDFVGAHRIQVDLMTRRFDVCGVWIVGIKRLIESLERIKMGPVGSSHQGHAGSPNDGLVSPGMNGQQQPSLGYQSSPPIPMGASNGQRPSMSYGNNAAFPPSPSLGYGGSHMQQQPLAPPPLAGPPPIGSGRPSISPYPSTMPTQNHMPLAPPPIAGSSQHMQNAFPPTISNGSNTQQTPPPPTSLSTFGAPPPGMSAPPPTTSTFKASMPPHTQMGGSGRSSFGAPPPSQPLQPIAPPPLGMMPPIQSAQHTSTFGNAPPVRSTSSMSYSSSVGNGIAPPPLHGQQRLPAQQPYFQGGNSGAPPPTTFGGPFPPPPVGSFSMPPPPPQ
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MEALSTSNAAEEKVPGRGLKFNASEGKDDGIGIDKFLRGKVIFISGATGFVGKVLVEKILRSVPNVSKMYLMMRAKDKEAAKQRLKTEAIDFELFKCVKQKYGKYYEAFTMSKLVPVEGNVCQSDLGLEEEIANAIKKGVQIIINSAANTSFYPSCEATLDINAMGPYHLMGFAKMCFKLELFLHLSTAYVNVPRPGRIMEQKLCMTNSMGRESLFSKSPGRFLPTLVLENENKVAAECKKTFANNAVAKKSKELGLQRAKEFGWTNAYVFTKALGEMIIDTMREDIPVVIIRPPAVEGTCKEPFPGWIEGHKSIDPIVSVYGKGKLKGFPGIADNVIDIVPVDMVVNETLAAMTRHGVTRKVDINIYHVSSSISNPLTLQDLCQLFYQHFKSLPCIGANGKHINIQKLKIFASMEEFDAHLLREATTNSSDMNPSGKIETRKFIELAKYLAKVYKPFTFYHYRQTGTPLFRCKLRRTEHLERLWIMILSVKLLTVDICGLYERKLKKLNPTTQNITCDIGVLYKFIGGLANIIALVYDSFSLSSSTFFWDVILFSTNNTQKLLESMSEVEKEKFGFDVKSIDWKHYIVNVHIPGLRRYVMKEKGVSKLTKRVALYDIIVKVIQFYEIILNFPISVVYDKMRYQIMKQRLRSSAV
The following text describes a protein:
Function:
Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen (By similarity).
Sequence:
MSTVLPESNATSRIPANDPALEKVDSEHGVEYAREKFGTALRGDRAGLKFESKFCPDDGRTPFATTAWDLRSAAIKDESGNALFEQTDCEVPASWSQLATNVVVSKYFYGDPKNTDERERSVRQLIHRVTRTISDWGLADGYFDTPEDGERFYRDLTWLSLHQHGAFNSPVWFNVGLHAQYDVEGDMCNWHWDRTENTTAQPDNPYEYPQGSACFIQSVDDNMEDIMRLACSEAMLFKFGSGTGTDLSTIRSQREKLSGGGTPSGPLSFMRVYDSIAGVVKSGGKTRRAAKMQSLKVWHPDILEFIECKWAEEKKAHALIREGYDSNFNGEAYASVCFQNANLSVRLTDDYMEAVRKNENFQTRWITDKPTTEPPSYVAKELLNKMAECAWHCGDPGVQYDTTINKWHTCPNSGAINASNPCSEYMFLDDTACNLASINLMKFVQQDGSFDHERFRAACRTFFIAQEILVDHASYPTEPIARNSHKFRPLGLGYSNLGSVIMTAGLPYDSDAARGMCGSLTALLHGEANRTSAELASVVGTFDGYVENEAPMLRVMQMHRDACDQINDDGPAELKEAARELWDGVLEIGEKYGFRNAQATVLAPTGTISFMMDCDTTGIEPDIALVKYKQLAGGGMLKIVNQTVKLGLKTLGYDADTIDEILKYVDANDTIEGAPGLQDEHLAVFDCAFKPANGVRSIGWRAHITMMAAAQPFLSGAISKTVNMPTDVTPQDIADAYFWGWELGLKAIAIYRDGSKQSQPLNTKSDEQKATDAAEAAKVETVEKIVYKPRRERLPDTRQSLTHKFSIAGHEGYLCVGLYPDGRPGEMFITMAKEGSTIGGIMDSFGTALSIAMQYGVPLEVIVNKFSHTRFEPMGHTSNKDIRIAKSVVDYIARWLGITFMSGNDYSPSAEGAAKTGGNGPDLTTAPAGATANNNSPVMAELRADAGAAVALVERATLLASLQNGVSNGSATNGHSNGQSAGGSSDGAVAERAVDGLGGQADQFSRFQTDAPSCDNCGSITVRNGNCYLCHNCGNSMGCS
The following text describes a protein:
Function:
Dioxygenase that cleaves the interphenyl C-alpha-C-beta double bond of resveratrol to yield 3,5-dihydroxybenzaldehyde and 4-hydroxybenzaldehyde. Also cleaves piceatannol, a compound that differs from resveratrol only in the occurrence of an additional hydroxyl group, which leads to the production of 3,4-dihydroxybenzaldehyde and 3,5-hydroxybenzaldehyde (By similarity).
Sequence:
MSEMRTHFPDRPQFSGFMKPCRVEGDISQLEVYGEIPKEIDGVFYRVMPDPQLPPFIENDPWFNGDGNVTAFRIQDGRASFRQRYVRTEKFMRERKAQRALLGKYRNKFTDAVEFRVRSTANTNVVFFNGQLLALKEDSPPYAMDPITLETKGLYDFEGQLPALTFTAHPKFDPVTGEMVCFGYEARGDGTPDVCYYRVSPTGQFKEVVWLVAPVVAMIHDFAVTDNWVVFPIIPQVCDIERMKQGGEHWQWSPETPLYLGVIPRRGAKGEDVKWFQYKNSFPGHTANAYEDKEGHLVIDLGLSEKNVFFWWPDAQGNAPEPSSIHSQLVRFTLNPHAEDLALPEPKILHQGNSEFYRIDDRFATHSYRHCYFDLMDPQLGTDFERIRPNLGGGYPLYNSLAHFDNATGQTEVYFPGNTHLVQEPVFIPRKDSTTEGDGWVLALVNNYATMASELHLLDTRDFTHAQAKILLPIRLRHGLHGSWVDGRDIGSQTEQLQ
The following text describes a protein:
Function:
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
Sequence:
MTHDLAASGLRFGIEEEFFLLDASDLDIVRSAPAGFVAACRDTLGEHFAEEMFECQVEVASPVFSTLAEAARFHGQARQRLAHLAMDFGLRSLCVGTHPFADWRRARSNPAAHFARLFEDQGRVARRSLVCGLHVHVEIPPSHDRMAVLQRVLPWLPLLLALSASSPFRGGRRSGLASYRRALCGEWPRMNIPPALPDEDAYRRHLALLRETGCIREDGQVWWMIRPSSHVPTLELRICDACPRLADALSLAGLFRALVGEALGADPRALPVARDACLEENYWQALRYGCAGRYLVEGRCVGAGDWLEMAWRQCRPQARQGNEWAYQHACGLLEETSAARQLRRYRRLREAGQERHPALRRLVEELLEENLQPALAG
The following text describes a protein:
Function:
Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Co-localizes with unc-38 and lev-1 at nerve cord synapses.
Sequence:
MRTNRLSWILVLSVVIFLVIINTINASDDEERLMVDVFRGYNSLIQPVRNSSELPLIVKMALQLVLLINVDEKDQVMHTNVWLTLQWHDFQMKWNPVNYGEIKQIRVSPDKVWLPDIVLFNNADGNYEVSFMCNVVINHKGDMLWVPPAIYKSSCIIDVEFFPFDEQVCTLVFGSWTYNENEIKLEFVQAELVDVSEYSASSIWDVIDVPASLVNKRSRIEFQVRIRRKTLFYTVVLIIPTVLMAFLSMAVFFLPTDSGEKITLTISVLLSIVVFLLLVSKILPPTSSTIPLMAKYLLLTFVLNVITILVTVIIINVYFRGPRTHRMPQWVRVVFLQFLPKLVCMKRPKSASERSAVRSGMAQLPGVGQFTLSPSAHHPLCPSADDRTTTIRNTASNETSAYYPLSTDALRAIDAIEYITEHLKRDEQHKSFRDDWKYVAMIIDRLLLYVFFGITVGGTCGILFSAPHVFQRIDQQEMLDRLKEKYDTASNIP
The following text describes a protein:
Function:
Damages membranes of susceptible bacteria. Has no hemolytic activity. Not toxic to mice. Does not inhibit the proteinases elastase and cathepsin G.
Subcellular Localization:
Secreted.
Sequence:
MTLRRGSCPLLLFSLVGLLTTCAQEPDAAGQNTTAVAEKAGTCPQAELEMPDRNCTEACQSDAGCEENKKCCRTGCGTSCQIPDEKPGSCPNVDTPIPPLGLCKTTCSKDSDCSETKKCCKNGCGFMTCTTARP
The following text describes a protein:
Function:
Pump for glutathione S-conjugates.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAITLTNFTFLYMDANLKRLGDIVLGFGANVVTLLLILILTITRRNGRCNRRKSYIEKCLLYVTPALGACLSCVDLVLLVRTNRRREVILCFVPLSGFVMWIAVILSLKFACCACHVFTSQILCFWWIFRFLTDALHLNMIFTLQRVQEICLIMLDIAFGISINVLRIKQAHPKIIPLEDPLIEDDDDQKRIVRRLFLEKNGSWWDLFTFGYIGSIMKHGSVKQLELENLLTLPPEMDPFTCCENLLRCWQLQECNNYSTPSLIWSIYGVYGWPYFRLGLLKVFNDCIGFAGPLLLNRLIKSFLDTQYTFRLSKLKLKLRSSIMSVIYRKCLWVNTANRSGFSEGEIQTFMSVDADRIVNLCNSLHDLWSLPLQIGIALYLLYTQVKFAFLSGLAITILLIPVNKWISVLIASATEKMMKLKDERIRKTGELLTNIRTLKMYGWDNWFADWLKETRATEVTHLATRKYLDAWCVFFWATTPTLFSLCTFGLFALMGHQLDAATVFTCLALFNSLISPLNSFPWVINGLIDAFISTRRVSKFLCCLEHSRDFSIDSGFTSEDLAVCVEDASCTWSSNVEEDYNLTIKQVSLRVPKGSFVAVIGEVGSGKTSLLNSLLGEMRCVHGSILLNGSVAYVPQVPWLLSGTVRENILFGKPFDSKRYFETLSACALDVDISLMVGGDMACIGDKGLNLSGGQRARFALARAVYHGSDMYLLDDVLSAVDSQVGCWILQRALLGPLLNKKTRVMCTHNIQAISCADMIVVMDKGKVNWSGSVTDMPKSISPTFSLTNEFDMSSPNHLTKRKETLSIKEDGVDEISEAAADIVKLEERKEGRVEMMVYRNYAVFSGWFITIVILVSAVLMQGSRNGNDLWLSYWVDKTGKGVSHYSTSFYLMVLCIFCIINSILTLVRAFSFAFGGLKAAVHVHNALISKLINAPTQFFDQTPSGRILNRFSSDLYTIDDSLPFILNILLANFVGLLGIIVVLSYVQVLFLLLLLPFWYIYSKLQVFYRSTSRELRRLDSVSRSPIYASFTETLDGSSTIRAFKSEEHFVGRFIEHLTLYQRTSYSEIIASLWLSLRLQLLGSMIVLFVAVMAVLGSGGNFPISFGTPGLVGLALSYAAPLVSLLGSLLTSFTETEKEMVSVERVLQYMDVPQEEVSGPQSLSDKWPVHGLVEFHNVTMRYISTLPPALTQISFTIQGGMHVGVIGRTGAGKSSILNALFRLTPVCSGEILVDGKNISHLPIRELRSCLAVVPQSPFLFQGSLRDNLDPLGLSEDWRIWEILDKCKVKAAVESVGGLDSYVKESGCSFSVGQRQLLCLARALLKSSKILCLDECTANIDVHTASLLHNTISSECKGVTVITIAHRISTVVDLDSILILDRGILVEQGKPQHLLQDDSSTFSSFVRASQ
The following text describes a protein:
Function:
Mediates tolerance to oxidative stresses (e.g. hydrogen peroxide H(2)O(2), diamide, menadione and tert-butyl hydroperoxide) by minimizing the negative effects of oxidation and monitoring photosynthesis during stress. Promotes root development. Prevents premature aging (e.g. senescence and flowering). Involved in resistance against compatible pathogens such as Botrytis cinerea and Pseudomonas syringae pv. tomato.
Subcellular Localization:
Mitochondrion.
Sequence:
MARSISNVKIVSAFVSRELSNAIFRRGYAATAAQGSVSSGGRSGAVASAVMKKKGVEESTQKISWVPDPKTGYYRPETGSNEIDAAELRAALLNNKQ
The following text describes a protein:
Function:
Probably transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.
Subcellular Localization:
Nucleus.
Sequence:
MASAVVDSGGSALELPSDGGENQEGGDTGPDCPAVIVEPVPSARLEQGYAAQVLVYDDETYMMQDVAEEQEVETENSETVEASVHSSNAHCTDKTIEAAEALLHMESPTCLRDSRSPVEVFVPPCISTPEFIHAAMRPDVITETVVEVSTEESEPMDASPIPTSPDSHEPMKKKKVGRKPKTQQSPVSNGSPELGIKKKAREGKGNTTYLWEFLLDLLQDKNTCPRYIKWTQREKGIFKLVDSKAVSKLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKDMPKNIVVIDDDKSETCPEDLAAAADDKSLERVSLSAESLLKAATAVRGGKNSSPLNCSRAEKGVARVVNITSPTHDGSSRSPTTTAPVSAAAAPRTVRVAMQVPVVMTSLGQKISAVAVQSVNAGTGSPLITSTSPASASSPKVVIQTVPTVMPASTENGDRITMQPAKIITIPATQLAQCQLQAKSNLTGSGSINIVGTPLAVRALTPVSIAHGTPVMRLSVPAQQASGQTPPRVISALLKGPEGKSEAKKQEHDVKTLQLVEEKGADGNKTVTHVVVVSAPSAIALPVTMKTEGLVTCEK
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MQPLAPDLTALERIRQTFAQPVLASFVAGGVAGAVSRTVVSPLERLKILFQVQSVGREEYKMSVPKALAKMWREEGWRGFMAGNGTNCIRIVPYSAVQFIEQLLEQHLKRVEEEENDSASVLRQQGTQLTYPQFFESEPGAPLDAYQRLLCGGLAGITSVTCTYPLDIVRTRLSIQSASFSSLKRAEGEKLPGMWSLLVNMYKTEGGFPALYRGIIPTVAGVAPYVGLNFMVYEMARTKFTPEGQKDPSAIGKLGAGAVSGAVAQTITYPFDVLRRRFQINTMSGMGYQYSGIFDAVSSIVRTEGVRGMYKGIVPNLLKVAPSMASSWLSFEMTRDMLMGKWNSGFL
The following text describes a protein:
Function:
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein.
Sequence:
MSLVRQIVSKMNKGIPEVERPKRSPTLKEKLAWTGLVLIVYYFLTQVPLYGVPRGGLDYLAQIRVIFAGAQGSIVELGIGPIVTAGIVLELLVGSKIVKLDLTDPEDRKFFQEAQRVAAIFFILFEVSAYTLGGRFGNLTTQQALMTIAQLSLGSFLLMMLDDLVAKWGIGSGISLFILAGVAQEAIWSMFSPKIEPTTKRYVGAIPALIAEGVGAIYRGSLPGLVGLISTFVVFIAVIWAYEVRVNISIAHSLYGGLRTKYPIRLLYVSNVPIIFASALLGDIDILAKIAWSRLGSETSGWAKYLVDFLGRYEADPVSGSVVPVQGLAYYLATPHGPSVLVQDPIRAIVYIVILIASCMAFAKIWVMTAGMDPRTISEQLVRQGIVVPGRRASAKVVARTIEKYIEAVTYLGGILVGLLAALANFTGAFGTGSGILLAVTIIAGLYERLAQERTLEMYPRLKRFIG
The following text describes a protein:
Function:
Transcriptional activator or repressor which serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: Produced by alternative initiation at Met-84 of isoform 1.
Subcellular Localization:
Nucleus.
Domain:
The two fingers are functionally distinct and cooperate to achieve specific, stable DNA binding. The first finger is necessary only for full specificity and stability of binding, whereas the second one is required for binding (By similarity).
Sequence:
MEFPGLGSLGTSEPLPQFVDPALVSSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAALAYYRDAEAYRHSPVFQVYPLLNCMEGIPGGSPYAGWAYGKTGLYPASTVCPTREDSPPQAVEDLDGKGSTSFLETLKTERLSPDLLTLGPALPSSLPVPNSAYGGPDFSSTFFSPTGSPLNSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRPLIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRKDGIQTRNRKASGKGKKKRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASGLTLGPPGTAHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVVAPLSS
The following text describes a protein:
Function:
Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.
Subcellular Localization:
Golgi apparatus, trans-Golgi network. Late endosome. Early endosome. Note=Localizes to the juxta-nuclear Golgi region and to tubular structures throughout the cytoplasm, which are highly mobile and cycle between the juxta-nuclear area and the cell periphery.
Sequence:
MGNCCWTQCFGLLRKEAGRLQRVGGGGGSKYFRTCSRGEHLTIEFENLVESDEGESPGSSHRPLTEEEIVDLRERHYDSIAEKQKDLDKKIQKELALQEEKLRLEEEALYAAQREAARAAKQRKLLEQERQRIVQQYHPSNNGEYQSSGPEDDFESCLRNMKSQYEVFRSSRLSSDATVLTPNTESSCDLMTKTKSTSGNDDSTSLDLEWEDEEGMNRMLPMRERSKTEEDILRAALKYSNKKTGSNPTSASDDSNGLEWENDFVSAEMDDNGNSEYSGFVNPVLELSDSGIRHSDTDQQTR
The following text describes a protein:
Function:
Plays a role in the cell surface localization of ORAI1 and may participate in the regulation of Ca(2+) signaling and the VWF release in response to inflammatory stimuli.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEGDCLSCMKYLMFVFNFFVFLGGACLLGVGIWVLVDPTGFREIVATNPLLTTGAYIVLAMGGLLFLLGFLGCCGAVRENRCLLLFFFLFILIIFLVELSAAILAFIFREHLTREFFTKELTKHYQGDNDTDVFSATWNSVMITFGCCGVNGPEDFKLASVFRLLTLDTEEVPKACCRREPQTRDGVVLSREECQLGRNPFINKQGCYTVILNTFETYVYLAGAFAIGVLAIELFLMVFAMCLFRGIQ
The following text describes a protein:
Function:
Positively regulates cyclic AMP-dependent protein kinase-mediated exit from the mitotic cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MNPSDLPGQIPLSRSDMNVQDQLDPVQRFDTHFMLPQEENFLNRPSITSESAHPRGSDLEQETELKRLALEHEHYSLESLAEKLRMDHVSANSEKFRQVFGICWLKRACEEQQDAAVQRNQIYAHYVEICNSLHIKPLNSASFGKLVRLLFPSIKTRRLGMRGHSKYHYCGIKLRGQDSFRRLRTFSDSSLSPVSCSSFPKPIPNHFENDVSSIQNTNQRVESSPASVNAAAIVRKSAVTPSSDPYNSPPPSIPLLGSQTNLQLAPSFAAPQAHPLPSHLSQSNVPPQLSHSSVPSPAPPRSVSQPTYFSQPMPQFSSSFVPGTSSIVPTLHPASAQEDFNLQHSLFFKLKLKFLPPHKLPWIPSLDVSSFSLPPIDYYLNGPYDNVEAKSALMNIYSSHCITLIESVRYMHLKQFLSEISNFPNSLSPSLLALLSSPYFTKWIERSDTVMYREILKLLFPMTLQVVPPPVLVLLRHLAENLVNHISSIYASHSSCLLQVKSETAAIFSNLLSRLLRVNDTAHAAARFLANPADRHLICNDWERFVSTRFIVHRELMCNDKEAVAALDEWYSILSTCSNPSELLDPLKDKHEASDTSMNRVELRQIDGVLDRMADFFLELPSRFPSCSPRMFLLCLGALQTSVLREITVSGGEAFGALWVIRCWVDEYMTWVAEIGGYLDDSYDELEQHHANFHNKAGISQSNIPPHLQEHRQSQQHFQQDIEALQSQQQQQATKNSLMEAAYQNAQKQKEDDYISIVFDTNGACS
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MYLLVHTIQYFGFFFSQFTNLVLLYLLWAKAGKQIGPFRYLMMSFSLYSVVYNYVDIVTHPLVLMEKQVCVVVNHGPFRYTPGFGYVLICIFGASFGLCISILCTQYMFRYIVICQQKHLHLIEGKRLALLFLYPFAISITWFSVCYFGLKITPEKRKALKITLQENYDEDSDVIMFAAAQYWILDDNGETTWCLRDCLAALGMVGLMVERICCFVVSFCGIKTFRKMMEVQASMSRQTVALNKTLLPSILMYGPVGLLFFAPLFEWNLQLLVSSAGATTAIYPAFEPLIVIFCISLFRRATFPCKQTNIITSSAALPSII
The following text describes a protein:
Function:
A DNA-guided ssDNA endonuclease that might play a role in defense against invading mobile genetic elements. Uses short ssDNA sequences as guides (gDNA) to bind complementary target strands, resulting in cleavage of the target DNA (tDNA). The cleavage site is 10 nucleotides (nt) downstream of the target residue base-paired with the 5'-end of the gDNA. Both 5'-P and 5'-OH gDNAs confer activity; a 5'-OH guide cleaves between nt 10-11 and nt 11-12. Guide DNA mismatches in the seed (nt 2-9) can enhance activity, mismatches 1-5 nt after the cleavage site block activity. Has no appreciable activity with guide RNA or on target RNA. In situ binds to 5'-phosphorylated DNA 14-20 nt in length; small DNA maps over the chromosome and plasmid with some preference for the replication origin and the probable termination site. Also has weak guide-independent nuclease activity on DNA called 'chopping'. Overexpression of wild-type or catalytically inactive mutant has no visible effect during growth under continuous high light for up to a month.
Domain:
Has 4 domains (N-terminal, PAZ, Mid and PIWI). The N-terminal and PAZ domains are joined by linker L1, the PAZ and Mid domains are joined by linker L2. The domains assemble in 2 lobes; the PAZ lobe consists of the N-terminal, L1, PAZ and L2 domains, while the PIWI lobe has the Mid and PIWI domains. The PIWI domain assumes an RNase H fold and has the catalytic residues. gDNA lies between the 2 lobes, with its unpaired 5'-end anchored in the Mid lobe.
Sequence:
MDLLSNLRRSSIVLNRFYVKSLSQSDLTAYEYRCIFKKTPELGDEKRLLASICYKLGAIAVRIGSNIITKEAVRPEKLQGHDWQLVQMGTKQLDCRNDAHRCALETFERKFLERDLSASSQTEVRKAAEGGLIWWVVGAKGIEKSGNGWEVHRGRRIDVSLDAEGNLYLEIDIHHRFYTPWTVHQWLEQYPEIPLSYVRNNYLDERHGFINWQYGRFTQERPQDILLDCLGMSLAEYHLNKGATEEEVQQSYVVYVKPISWRKGKLTAHLSRRLSPSLTMEMLAKVAEDSTVCDREKREIRAVFKSIKQSINQRLQEAQKTASWILTKTYGISSPAIALSCDGYLLPAAKLLAANKQPVSKTADIRNKGCAKIGETSFGYLNLYNNQLQYPLEVHKCLLEIANKNNLQLSLDQRRVLSDYPQDDLDQQMFWQTWSSQGIKTVLVVMPWDSHHDKQKIRIQAIQAGIATQFMVPLPKADKYKALNVTLGLLCKAGWQPIQLESVDHPEVADLIIGFDTGTNRELYYGTSAFAVLADGQSLGWELPAVQRGETFSGQAIWQTVSKLIIKFYQICQRYPQKLLLMRDGLVQEGEFQQTIELLKERKIAVDVISVRKSGAGRMGQEIYENGQLVYRDAAIGSVILQPAERSFIMVTSQPVSKTIGSIRPLRIVHEYGSTDLELLALQTYHLTQLHPASGFRSCRLPWVLHLADRSSKEFQRIGQISVLQNISRDKLIAV
The following text describes a protein:
Function:
Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway.
Miscellaneous:
MISCELLANEOUS: Present with 1180 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MLKEPSVRLREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRDKGNWKPIDVAQTFEVGNIYSKVLKEVKKKGPPLGAGKKPSSFRTPILNAKATFEDGPSPVLSMNSPYSLYSNNSPLPVLPRRISTHTTSGNGGNRRSSITNPVFNPRKPTLSTDSFSSSSNSSSRLRVNSINVKTPVGVSPKKELVSESVRHSATPTSPHNNIALINRYLLPNKSNDNVRGDSQTATINDDGGGGNGGDATIGMGLRKDPDDENENKYKIKVNNGEPRRRVSLLNIPISKLRNSNNTRAED