lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.
Sequence:
MSQVPTTYSFDAPTDFINFSSLDAEEDTENIDSWFDEKANLENKFLRQRGIGEPFQGKNSLRKAKLQQGFVTPLKAVDNTYHKETEKENLQKQSIPSNDCSSLDAKRAVSGNTPVQPQRRSIRLSAQKDLEQKEKNHVASVEMKAKRCVAPATDCPPQKRMKVSHKKKLEEEEEGSAPATSRKNERETLEKAKGKHTVPGVPPAREKVLKSTEEQEIEKRLRMQQEVVELRRKNEEFKKLALAGPGQPVKKSTSQVTKTVDFHFLTDERIKQHPKNQEEYKEVNFMSELRKHSSTPARGTRGCTIIKPFNLSKGKKRTFDEAASTYVPIAQQVEAFHKRTPNRYHLRNKKDESLLPSKSVNKIARDPQTPILQTKYRTRAVTCKSTAEQEAEELEKLQQYKFKARELDPRIFESGPILPKRAPVKPPTQPVGFDLEIEKRIHERESKKKTEDEQFEFHSRPCPTKILEDVVGVPEKKVIPATVPKSPVFALKNRIRVPIKDEEEEKPVVIKAQPVPHYGVPYKPHIAEARNVEVCPFSFDTRDKERQLQKEKKIKEMQKGEVPKFKALPVPHFDTINLPEKKVKNVTQAEPFSLETDKRGAYKAEMWKHQLEEEQKQQKDAACFKARPNTVIFQEPFVPKKEKKSLAENPSGSLVQEPFQLATERRAKERQELEKKMAEVEAWKLQQLEEVRQQEEEQQKEELARLRKELVHKANPIRKYAAVEVKSSELPLTVPVSPKFSTRFQ
The following text describes a protein:
Function:
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
Miscellaneous:
MISCELLANEOUS: [Isoform RIN1-delta]: Shows reduced ability to bind to Ras and 14-3-3 proteins.
Subcellular Localization:
Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.
Sequence:
MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRERLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSHYILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHLGIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAPERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPEKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPLSPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRAAEE
The following text describes a protein:
Function:
Involved in transcriptional regulation. Component of the NC2 complex which represses RNA polymerase II transcription through binding to tbp and thereby inhibiting the assembly of the preinitiation complex (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGDKNDKEDNLSLPKATVSKLIKEMLPQDVKCSNETRDLILECCVEFIHLISSEANDICGREQKRTIAAEHVIKALTELGFSDYTQKVSDVYDKHKLEVSTKSKSSKKFENLGKPTEQLIREQQLLFAKARSAFQASPEAQQLQQLQQQQQQQQGGLQAPSVQQQTDINTTTTSTIQK
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MNTKNATREEKKKELELNEARKAGKVEALKDEEGNDINPHMPQYIIKAPWYLNQTKPGLKHQRYKGSDKIKIEEERNKKLFLNNNKGQDFCKNCGSVAHKEKDCLERTRKKKVNFMKNDNEDFICVTQDLGYDGNRDRWVGYNVNNFDYIYKEYEKIVEEKKKRKAEDLKKQYEKKSVKKKKTHDNNDDNNNGDNNNDDDEKSSSESENLDESSNEDNKLKPDIMNNQNCTINKNEKNRNIARNLRIREDTAKYLYNLSLNSAFYDPKSRSMREDPFANIRKHLNDDDNYYKGENYYNNTDDAIESKKLEVFAWESYKRGENVHFNAQPTQLELMYKEYLEKKKKIIKKKQEDILKTYKCQNNEEQQPNQEELLQSEVYTEYKPIEQIHNNNMKKNIKVPSKYEEDIYLFDHSSVFGSYYDKHTKKWGYKCCSSTNKYDKCFQT
The following text describes a protein:
Function:
5'->3' exonuclease that hydrolyzes the phosphodiester bond of single-stranded DNA (ssDNA) and RNA molecules to form nucleoside 3'-monophosphates and 5'-end 5'-hydroxy deoxyribonucleotide/ribonucleotide fragments. Partially redundant with PLD4, can cleave all four nucleotides displaying higher efficiency for ssDNA and RNA fragments initiated with uridine and guanosine residues and lower efficiency for cytidine-initiated substrates. As a result, it does not always degrade polynucleotides to the single nucleotide level, it can stall at specific sites sparing certain fragments from exonucleolytic degradation. Processes self and pathogenic ssDNA and RNA molecules that reach the endolysosomal compartment via phagocytosis or autophagy and may serve as 'danger' signals for recognition by innate immune receptors such as toll-like receptors (TLRs). Degrades mitochondrial CpG-rich ssDNA fragments to prevent TLR9 activation and autoinflammatory response, but it can cleave viral RNA to generate ligands for TLR7 activation and initiate antiviral immune responses. In plasmacytoid dendritic cells, it cooperates with endonuclease RNASET2 to release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP), a potent stimulatory ligand for TLR7. Produces 2',3'-cGMPs and cytidine-rich RNA fragments that occupy TLR7 ligand-binding pockets and trigger a signaling-competent state. Can exert polynucleotide phosphatase activity toward 5'-phosphorylated ssDNA substrates although at a slow rate. Transphosphatidylase that catalyzes the exchange with R to S stereo-inversion of the glycerol moiety between (S,R)-lysophosphatidylglycerol (LPG) and monoacylglycerol (MAG) substrates to yield (S,S)-bis(monoacylglycero)phosphate (BMP). Can synthesize a variety of (S,S)-BMPs representing the main phospholipid constituent of lysosomal intralumenal vesicle (ILV) membranes that bind acid hydrolases for lipid degradation. Regulates the homeostasis and interorganellar communication of the endolysosomal system with an overall impact on cellular removal of dysfunctional organelles via autophagy as well as proper protein and lipid turnover. May play a role in myotube formation in response to ER stress (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein. Nucleus. Early endosome. Cytoplasmic vesicle, phagosome. Lysosome. Note=Activation of microglia induces translocation of PLD4 from the nucleus to the phagosomes.
Sequence:
MDKKKEHPEMRIPLQTAVEVSDWPCSTSHDPHSGLGMVLGMLAVLGLSSVTLILFLWQGATSFTSHRMFPEEVPSWSWETLKGDAEQQNNSCQLILVESIPEDLPFAAGSPTAQPLAQAWLQLLDTARESVHIASYYWSLTGLDIGVNDSSSRQGEALLQKFQQLLLRNISVVVATHSPTLAKTSTDLQVLAAHGAQIRQVPMKQLTGGVLHSKFWVVDGRHIYVGSANMDWRSLTQVKELGAIIYNCSNLAQDLEKTFQTYWVLGTPQAVLPKTWPRNFSSHINRFHPLRGPFDGVPTTAYFSASPPSLCPHGRTRDLDAVLGVMEGARQFIYVSVMEYFPTTRFTHHARYWPVLDNALRAAALNKGVHVRLLVSCWFNTDPTMFAYLRSLQAFSNPSAGISVDVKVFIVPVGNHSNIPFSRVNHSKFMVTDKTAYVGTSNWSEDYFSHTAGVGLIVSQKTPRAQPGATTVQEQLRQLFERDWSSHYAMDLDRQVPSQDCVW
The following text describes a protein:
Function:
Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors. May play a role in the regulation of spermatogenesis.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome.
Sequence:
MENSSSFDRVRIAVRERPIAEEDILGVKLHVRQSEGKLFAYSPDATEGLMYDCDYFFPCSAKQEELYHAIGLEMIDLVAQGLSSNVVVMGFAVTGKTHTLFGDNESVGLIYDTVGGLYQRLGAVAGEFETDIVLRYWEMNRDSVEDNLLDEDGSERAYTVTRDTFDRLVIPNLMAVRVPTFEDFLEQLERGNRNRVRRTKQRQSRWHGFLQLMVSTTPKVDSGKTVIRSMTFVHLKGTDCLGLKGVAGDQLKEGCGINVSVTLLRAAVIHSINYREKRRSRATTPEGHHDLICSSQSFFMECKFSRLMSQFISGLEASFVVGCTNPLQFKESIDTLENLQYFRRLRCALKAIVVVSERGLLLKELRRQEELLGAEAVAELYGSDANGCPLNEAEEKLLQIYRKLHGFDPRRGAVKSPAVDPEAAIIERCKTRAQRLHGKVDTHGMRKRIFLTPRKTESYEGQWEDGKFGGFGELLKKLSKYRGEFRNGLREGEGTLWLRKDVKSPWVRVYRGEWLAGKRDGVGISWEENGDVYEGGWSGGKRDGFGRLFFANGDIYKGEFRDDQHYGRGILRLTSGDWYDGYWALGLREGPGLWCYTQKQQYFVGEWSKGICKCGTMLDMPDKTTNENSRFIPRLGLLRCDEVLELEQLKLRDRRAQEYPEMNVEWRTPLVSAPLGALSKNVDSTSGGGDDLDAGNSSRDGEESVGTNVAEGWGLDVE
The following text describes a protein:
Function:
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
Subcellular Localization:
Secreted.
Sequence:
MAEEGFHSRLWTQPGPNLSPLASQQLQSQASEAAATSKEKKKKQRKKGRRKSAAKRRMKSAAQNGILSLVCIALCWFLKCSAAPMPESSGDPELIQFKWKNKEFVARMKSEISDLKESMRTDFSLGTDDQFLFMQDFLGIEQADHSHCQKATCDLGNCFKQLRAGLHTYYGYLSHIKQILPNYTNRVSSLQLDTSNLSTNIQLQFEESSLPVVTYPQAENQPNFLQEQREIGSYLVLRKFMLFMDVITRALNHCIV
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MSEEIISKKPSKPQASRKGKRAWRKNIDIQEIEQNLQDKRDEEIVLGKEVTDDFVIDDTPSSKSGKLPKKLKTKEILTNKSKIPALTNQRHQKKGENTIQGVKKTDLLRLIQLNGGKFKSEDKYVNRLEQDGIVNGSSQDLWDDTDNNEKKKIPDFMKSTAEVTKASVVPKTLKVNPIKITSNELTDKKIHAGKSYNPSLESWKELINQEYDIEYKRELTRQQIEEHRNKIKELMITLDDNMLSDSDDDEDDEDNDKVEEEEQLNANGEKDYSLSINKPNKIKIKTKTKRNKELKHKERVKLEQQIKDLKKQLKDLSNLDEILEKQAVKDQSQPNEKKRKRREKLFKYSLVETPLEVKLSDELSGNLKNLKPEGNLYYDQMLSLQSSGKIESRVPVNKKRKYTKKITEKWTYKDFK
The following text describes a protein:
Function:
Probable histone deacetylase. Histone deacetylases are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MLFEDRQKNRSTGPTLIGFNQTQNEHENTVCPTHPESSDRILKIKEALTKTKILEKCTVLTNFLEIDDADLEVTHDKSMVKDLMESEKKTQEDINSQCEKYDSVFMTENSMKVAKDGVACVRDLTNRIMANEASNGFAVVRPPGHHADSVSPCGFCLFNNVAQAAEEAFFSGAERILIVDLDVHHGHGTQRIFYDDKRVLYFSIHRHEHGLFWPHLPESDFDHIGSGKGLGYNANLALNETGCTDSDYLSIIFHVLLPLATQFDPHFVIISAGFDALLGDPLGGMCLTPDGYSHILYHLKSLAQGRMLVVLEGGYNHQISAVAVQRCVRVLLGYAPFSIELNEAPKESTVDSCVSLVSVLRHHWNCFDYFPSRTSLRLAQWPIVNTKVIYNYDPTTRRADTGEIIQDELASTEFTASDVIPTENMETLIYFNEGDDAHFDLEEDNHPEKPARTRRILKTLRESGVLEKCVDRNCERIATNEEIRLVHTKKMLEHLRTTETMKDEELMEEAEKEFNSIYLTRDTLKVARKAVGAVLQSVDEIFEKDAGQRNALVIVRPPGHHASASKSSGFCIFNNVAVAAKYAQRRHKAKRVLILDWDVHHGNGTQEIFYEDSNVMYMSIHRHDKGNFYPIGEPKDYSDVGEGAGEGMSVNVPFSGVQMGDNEYQMAFQRVIMPIAYQFNPDLVLISAGFDAAVDDPLGEYKVTPETFALMTYQLSSLAGGRIITVLEGGYNLTSISNSAQAVCEVLQNRSMLRRLREEKEQFATKPQKIESSCIKTIREVCAVQQKYWSILKGFQVTPSNYGLDIDDEAYDDDSIDMADQSSSSGSSSSSTRPSHNLEIMDSGPAHAVVPLATCPHLKEVKPLPPAKINARTACSECQIGAEVWTCLTCYKYNCGRFVNEHAMMHHLSSSHPMALSMADLSVWCYPCDSYVHNPALIGAKSAAHESKFGETMPS
The following text describes a protein:
Function:
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
Subcellular Localization:
Cytoplasm.
Sequence:
MLMTRPNLKGRSFLAEKDFTQEELLYFLDLAAELKEKKKNGIPHHYLEGKNVALLFEKTSTRTRCAFTVACTDLGANPEYLGKGDIQLGKKESVEDTAKVLGRMFDGIEFRGFNHETVESLAQNSGVPVWNGLTDMWHPTQTLADLLTIREHIGKLKNVKLVYVGDGRNNVANSLLVGGAIVGMDVRICTPESLWPAQEVIDLAKKYNEQVMITSNVEEAVANADVIYTDVWVSMGEEEKFAERVELLKPYQVNMKMIKATGNENVIFLHCLPAFHDVETMYGEEVYEKYGLKEMEVTDEVFRSKHSKVFDQAENRMHTIKAVMAATLGNME
The following text describes a protein:
Function:
Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP.
Subcellular Localization:
Cytoplasm.
Sequence:
MTAWTMGARGLDKRGSFFKLIDTIASEIGELKQEMVRTDVNLENGLEPAETHSMVRHKDGGYSEEEDVKTCARDSGYDSLSNRLSILDRLLHTHPIWLQLSLSEEEAAEVLQAQPPGIFLVHKSTKMQKKVLSLRLPCEFGAPLKEFAIKESTYTFSLEGSGISFADLFRLIAFYCISRDVLPFTLKLPYAISTAKSEAQLEELAQMGLNFWSSPADSKPPNLPPPHRPLSSDGVCPASLRQLCLINGVHSIKTRTPSELECSQTNGALCFINPLFLKVHSQDLSGGLKRPSTRTPNANGTERTRSPPPRPPPPAINSLHTSPRLARTETQTSMPETVNHNKHGNVALPGTKPTPIPPPRLKKQASFLEAEGGAKTLSGGRPGAGPELELGTAGSPGGAPPEAAPGDCTRAPPPSSESRPPCHGGRQRLSDMSISTSSSDSLEFDRSMPLFGYEADTNSSLEDYEGESDQETMAPPIKSKKKRSSSFVLPKLVKSQLQKVSGVFSSFMTPEKRMVRRIAELSRDKCTYFGCLVQDYVSFLQENKECHVSSTDMLQTIRQFMTQVKNYLSQSSELDPPIESLIPEDQIDVVLEKAMHKCILKPLKGHVEAMLKDFHMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSETRDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS
The following text describes a protein:
Function:
Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis; Multifunctional protein that is involved in the regulation of many processes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEMKKRISLELRNKSPAEVAELVLDNCRSVDGEIEGLNESYKELEFLSMANVELKSLSKLPKLPKLRKLELSDNSISGGLDVLTDRCPNITYLNLSGNKIKDLSTVEALANLKNLKCLDLFNCEITNLEDYRENIFQRLSQITYLDGFDQEDNEAPDSEEDVEDEEFEYDDSDEEPGSLSSEDDVDDEGASDLGEEEEEEEEEEVGLSYLMKEEIRDEEDDDDYVEDGAEIKEEEEEGEEHEAADQGEKRKREPEDEGDEDED
The following text describes a protein:
Function:
Involved in the biosynthesis of the antibiotic D-cycloserine (DCS), a cyclic structural analog of D-alanine, used as an antitubercular agent. Catalyzes the hydrolysis of N(omega)-hydroxy-L-arginine (NHA) to yield hydroxyurea (HU) and L-ornithine.
Sequence:
MIDLIVSQGRVADRAAWMIEGAARTARALEERYGLKGHYVGEPAPHADDDWSVALPQARETLVAVREAATESIKGDNLTVLVNNTCSVSLATLPVVAREHPDAVVLYIDGHGDFNTPETTDTGYLGGMVLSGACGLWDSGHGAGLRPEQAVLVGSRDIDEGERELIRKAGVRVIPPGEATAQAVLDAVKDAPVWIHIDWDVLEPGSIPADYTVPDGMLPAQIRAVFEAIPAERLIGVELAELNAPADSERAEQAVAVILDMVAPAFDAAAARP
The following text describes a protein:
Function:
GTPase system comprising ran-1, ran-2 and ran-3 is essential in nucleocytoplasmic trafficking. Ran-2 is a GTPase activator for the nuclear RAS-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for correct chromosome alignment and segregation on the metaphase plate.
Subcellular Localization:
Nucleus.
Sequence:
MLPRLFLTILPVCSPSISNKTSKKFRDAHANHVFLFEMDLNNTLSFFGKQLKLDTEEEISKVIDQIRKHLNLEVLDFRGNTLSVLAGKLIAESLKTRRELKECIWSDMFTGRLKDEIPLVLDALGEALTASGCRLTTLDLSDNAFGAGLSTSLYNFLQSPALYSLENLILNNNGLGLAGKTVGKALCSLIDASKKAGTPLKLKKFVCGRNRLEVESTIALSDAFIKLGTLEEIRLPQNGIRDDGIIALAEAFRMNKKLRIIDINDNFCCPEGAIQISEVLSDLQFIEVLDLGDCVCDDPGVLAIIAELDKINRDCLKKVVLSGNNITSDVIDEIGACFNSPKMCHVKVDISVNMFGKDFDSAKARHGKGNIDFGRRGDDELLSSDEEEEQGAEDASMEEDAFNTSRETVIDRSNLHEASADEMMNDLMNKGFGCMKIEDNQQNSNGNGMVSFLDKSLKLDTAESAEPVVKVIAAASSMKALELRGNTLGIAAGNVIAKALESHPELERCLWSDLFTGRLKNEIPPILEALGKAMMTAGCKIKELDLSDNAFGPIGADALKDLLESPSSFSLEVLKLNNNGLGIGGKQIAKSLTECLRKSIAVGGENRLRLKTFIAGRNRLENPGAHALAATFKALETVEWFDVRQNGIHEEGIRALVAALKHNRNLRYLWLEDNTVLPKGAKALAKTLESWPKLEVLNLSDCLIRDAGCNYIIDHLNPQHHRHLKNVYLCGNELTPPVAKLLIQKWSKFDGLTPKPVLHIHTNSFGDEFSDVAGMAPENVNVGDEDDDLGSLDGDQEEYNSKSSDSEDADLDDDDEDDDEEAEIQIIDNGESQLKLAMDRIDRLDIDFESRFQEDTARVILQLSAPLKSCKMSEPALQRAIEVAENIVRRVESVKRNPIPATTQLVNNIVAQCAGTGVKAETDWGYGADPQVISRLFSELVARGHFKLELALLQRFFPSQ
The following text describes a protein:
Function:
Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKTLPAMLGTGKLFWVFFLIPYLDIWNIHGKESCDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSYRCSANFQSNLIESHSTTLYVTDVKSASERPSKDEMASRPWLLYSLLPLGGLPLLITTCFCLFCCLRRHQGKQNELSDTAGREITLVDAHLKSEQTEASTRQNSQVLLSETGIYDNDPDLCFRMQEGSEVYSNPCLEENKPGIVYASLNHSVIGPNSRLARNVKEAPTEYASICVRS
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSSPSPSVSGDNKQIDQIHFRFCRECSNLLYPKEDRVNNRLMFTCRTCHVGEPATSYCVYQNKLNSQVGDTAGVTQDVGSDPTLPRSNKPCPSCGEAEAVFFQSQQRSAETGMKLYYVCCACGNVFV
The following text describes a protein:
Function:
Serine/threonine protein kinase involved in the regulation of exocytosis. Induces phosphorylation of SEC9 and its release from the plasma membrane to the cytosol.
Miscellaneous:
MISCELLANEOUS: Present with 279 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MDDYHVNTAFSMGRGNQQDDGNSESNSMHTQPSTMAPATLRMMGKSPQQQQQQNTPLMPPADIKYANNGNSHQAEQKERQVELEGKSRENAPKPNTTSQSRVSSSQGMPKQFHRKSLGDWEFVETVGAGSMGKVKLAKHRYTNEVCAVKIVNRATKAFLHKEQMLPPPKNEQDVLERQKKLEKEISRDKRTIREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQHGSIREHQARKFARGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQLHTFCGSLYFAAPELLKANPYTGPEVDVWSFGVVLFVLVCGKVPFDDENSSVLHEKIKQGKVEYPQHLSIEVISLLSKMLVVDPKRRATLKQVVEHHWMVRGFNGPPPSYLPKRVPLTIEMLDINVLKEMYRLEFIDDVEETRSVLVSIITDPTYVLLSRQYWTLAAKMNAESSDNGNAPNITESFEDPTRAYHPMISIYYLTSEMLDRKHAKIRNQQQRQSHENIEKLSEIPESVKQRDVEVNTTAMKSEPEATLATKDTSVPFTPKNSDGTEPPLHVLIPPRLAMPEQAHTSPTSRKSSDNQRREMEYALSPTPQGNDYQQFRVPSTTGDPSEKAKFGNIFRKLSQRRKKTIEQTSVNSNNSINKPVQKTHSRAVSDFVPGFAKPSYDSNYTMNEPVKTNDSRGGNKGDFPALPADAENMVEKQREKQIEEDIMKLHDINKQNNEVAKGSGREAYAAQKFEGSDDDENHPLPPLNVAKGRKLHPSARAKSVGHARRESLKYMRPPMPSSAYPQQELIDTGFLESSDDNKSDSLGNVTSQTNDSVSVHSVNAHINSPSVEKELTDEEILQEASRAPAGSMPSIDFPRSLFLKGFFSVQTTSSKPLPIVRYKIMFVLRKMNIEFKEVKGGFVCMQRFSSNNVAAKREGTPRSIMPLSHHESIRRQGSNKYSPSSPLTTNSIHQRKTSITETYGDDKHSGTSLENIHQQGDGSEGMTTTEKEPIKFEIHIVKVRIVGLAGVHFKKISGNTWLYKELASSILKELKL
The following text describes a protein:
Function:
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
Subcellular Localization:
Nucleus.
Sequence:
MDSHNCTTVSDSALEIENQSDSSSSGSSLFKTQCVPNPPNPPKQRQRNPIRKYIYSPVSIDTEDSSSDSSIEPRPLTLKAIFERFKRKKRKKKKKKKKYKPTGRSRGRPKGRKNTRVSQINKIKFKDKGPGFPFLEAENGRKPLPWRKILTFEQAVARGFFNYLEKLKYEYHLKESLKQMNVGEDLEREDLDSRRYKYLDDDGSISPIEELTAEEENATNLEHDECDIKLVENNYFIISSELPKKKNLLCLKRKHQNPKNKTVDRGQNALKRK
The following text describes a protein:
Function:
Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.
Subcellular Localization:
Cell junction, focal adhesion. Cytoplasm, cytoskeleton, stress fiber.
Sequence:
MLACLTRGNLLDVLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQLSPSNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFKPGSSRTVNQGRDSRAPLQSHRPHCATAVAQGAAAALADVCHDMSRSGRDVFRYRQRNSSMDEEIENPYWSVRALVQQYEGQQRSPSESSCSSLTSPSPIHSAKSESIITQSEEKADFVIIPSEGIENRTEGTDSALSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGAASISNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRTQVGSEYRESWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGNHRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGEN
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Sequence:
MSAQPVNPNVPPDHVTVEIDGQSLVVPKGSMIIQAADKAGIPIPRFCYHEKLPIAANCRMCLVDVEKSPKPSPACATPVMDGMKVTTRSEKALKYQRSVMEFLLINHPLDCPICDQGGECELQDVSLGYGRSVSRFNERKRVVPDEDIGPLVATEMTRCIQCTRCVRFTADIAGTYELGGMYRGENLQIGTYDGKPLTTEISGNVIDVCPVGALTNKVFQFRARPWELMARESLGYHDAMGSNLFLHVRRGEVLRTVPRENEAVNECWLSDRDRYSHQGLYAEDRAVKPLKKVNGEWTEVSWAEGLAAATQILRDNAGDQLGVLVHPATSNEEGALLARLAEGLGSGNLDHRLLNRDFSDAAVAEAFATPLAEIEQADVVVLFGTNVRHELPLLHARLRKASIQNRTQIHSVNPVDFDFAFTQASRTVVSPTQLAGALDDATLRDAVKGASRAVIVVGALAENHPQAATLRAAARAFAAATGASLCRIPQGANAVGLVSQGVLPTARTVAGMFAEPRQAYVVYGIEPGLDFADAAAARSALAGAKVVAFSQFACASTRDVADVILPIGALPEIDASLTNLDGRVQTARAAGRLPVEAREGWRVLRALGGELGLAGFEFIDLVGLRAGMQQRSVTAATSAQPATASEGLEVAATAAIYRTDAVVRRAAALQSHPLNIAPCVAMHPEQAAQLQVAAGQVVKVGTDAGRATLPVVLDKRVAPGTVWIESGHGATAPLGAGRVTVVAA
The following text describes a protein:
Function:
Plays a role in dendrite formation by melanocytes.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MLEPINEGFLSRLSDLLLCRWTCRHCCQKCYECSCCQSNEDEVEILGPFPAQTPPWLLSNRNGDKNGDPDNVAGEAPPTPQDPSPDRRRSSSDTSKSTYSLTRRISSLEARRPSSPLIDIKPIEFGIIGAKKEIIQPSVLRKTYTPDDYFRKFEPRLYSLDSNSEDMDSLTDEEILSKYQLGKLHFSTQYDLLHNYLIVRVIEARDLPAPISYDGSRQDMAHSNPYVKICLLPDQKNSKQTGVKRKTQNPVFEERYTFEIPFLEAQRRTLLLTMVDFDKFSRHCVIGKVSMPLSEVDLVKGGHWWKALVPSSQNEVELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDMSQGSDPFVKVQLVHGLKLAKTKKTSFMRGTIDPFYNESFSFKVPQEELENASLVFTVYGHNVKSSNDFVGRIVIGQYSSGSSESNHWRRMLNAHRTAVEQWHSLRSRDECDRVSPASLEVT
The following text describes a protein:
Function:
Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
Subcellular Localization:
Bacterial flagellum basal body.
Sequence:
MAINFDKALGVHQFTLGIRSERAEVLASNIANADTPHYKARDVDFSAALNVAKTQQQQRNSLEMTGDEQHFGLAQLTGQYVKFRVPNQPDTGDGNTVDVQQEQSAFMQNALEYQMSLGFLDSKFSGMKKALRGD
The following text describes a protein:
Function:
Axonemal protein which is implicated in axonemal and/or peri-axonemal structure assembly and regulates flagellum assembly and beating.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Domain:
The TPR repeats are required for axonemal localization and flagellar beating.
Sequence:
MASVGPVKTKTVTLKELTPPIPSPEKSACKGAKPDSNHMALVPVKPSQPGSGKLITRTRLQRDSLISQQQRDALVVSSFGIGTTRHGQPDNTTSSIKDGFSTAAGGVNCASVVVAQSEKDSVRFHLCVDALAEGCVNTFIHLFHLSHRDPVCVDQLAQTLFTIPDEKLVWVKSQLAAVEVLRRQSEFRDVCERCQLLADYFESERDCDEAAWHYDVALRIAMESLDRPLEQEVRLSFGAFFERHKQLRKAIALFEEVYHLAMALNDVETAVEANYRLIRTYLSLSAELKDTNPKEAISFLERALDMSQRVKSSKDEADSLHALGNIYESMGDFRRALEYQKRFFEVARAANLVEREKRASLCVASMQERMNMTDEAVHSLQCALELSEKAADIEGVYRATMQLGQAYDSSGDHEKALMSYRANFGAARKLNNSDLTDQARVALGFALGEHYLKHAGGGRGYVPIVCDDVKAQLEWMSNGIL