lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex receptor (SR) (By similarity). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May mediate the membrane association of SR (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MDGTSQAFKIIVATIIIGAIISTLGIFFTRKTIQKKLPAVFLIGPSDSGKTSLFCELIYKEKKTTVPSIEPNEAVWKYGAWLVDLPGHPRAKRWITTKFSGNYNVKAVVFVLNSATIDRDVHEVGLMLFDTILKCRKHHVPHLLIACNKFDLFTAQPAEKIQQLLKAELHNILEEKNLQLESIVSEDVDWESVADQIEDTDLKFLPGSVAKMSNIEEWISWMESALQ
The following text describes a protein:
Function:
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
Subcellular Localization:
Secreted.
Sequence:
QLGLQDPPHMVADLSKKQGPWVEEEEAAYGWMDF
The following text describes a protein:
Function:
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
Miscellaneous:
MISCELLANEOUS: Enzyme activity requires the presence of both kinase domains.
Subcellular Localization:
Nucleus.
Sequence:
MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS
The following text describes a protein:
Function:
Plays a role in negative regulation of the JAK/STAT pathway by binding to the receptor dome and promoting its internalization for subsequent lysosomal degradation, thereby reducing JAK/STAT signaling.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MERVHLTAWLALFLIVVANATPTPARTPTGCPADCTCSLSQHTHKPLYHLKCNSTRGLRLTEKTFQSTVPVHSIDLSHLNLTRLSHLLDKLPELTSADLSHNQLKDLGHLGKGLKRLNLKHNQLTSDKLRKLPQHLQVLNLQHNNITHLPLELTHMHQLHQLELSHNAINCSCQTLEVRNWLVERIVYMEHPVVCSYPLEFRGRSWLQLKQDEICKKEKYQWFDTEENELMMGDQPAAVSAEREDEEELGKDFLPIVGNPAATAKKVRSPQIPLPSDQVEGSGDLSETNMELKLPEETVAEPEAAESQLVDAAASPSVLEEHIVKDEDEDDEGSGSGGGLLIIPDPSKVKITSEDDIDSDGKPEESDVRPLENPENSENPDTVFSNKIGIYEGDQEEKKPVEEDNIVPVVMTNLDTGLESDVVTDGPLDSSKESEDILTAKIGKPKDDSSAIYYLLAVIGLIVVGLVLFVAIKRCKYDSNAAARDAEAQRQTELLDMDKKQLGKPLHKNGHGNGQEHSPLIGEKTKLDEAQIVKKPYENGEAKDGAGQQPLLNGNGSANGGTKEAPETGEPAAHEYYPITPRYPTPQSPRASKYAQQQQLAEQNNNEPDGAYLPSSPKSGRYSPVYSPETGRVKIKLTETPKPKTPMLVTRSKSNAGDIITTPVRPIEPTHQVINGH
The following text describes a protein:
Function:
Involved in the maintenance of both rod and cone photoreceptor cells (By similarity). Required for photoreceptor-specific localization of proximal connecting cilium (CC) proteins RPGR, AHI1, NPHP1, NPHP4, and RPGRIP1 at the distal CC, a photoreceptor-specific extension of the primary cilium transition zone (By similarity). Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton. Cell projection, cilium, photoreceptor outer segment. Note=Localizes to the microtubule network.
Sequence:
MAVHYNKILSAKAAVDCSIPVSVNASIKYADQQRREKLRKELARCEKEFKLSKSAMQTNSKMNSKFFVNSLQRPSGEPQDQDVLIEERLTRYPSFSKSLIPSPEGLHLSLPESNKILMNGTQKYPSTAPPRYSGCGHGYDRRPRSAHQFQVVISKTPSGDLLEKHADLFSNNQSPFTPRTLKTEAKSFLSQYRYYTPAKRRRDFSDQRMEAETQTELSSFNSELGTAEKKSSKDSDVSIKQAPNYMRNGAEDKIAPLSLQGQNLAWDKSKDGILQPSSERAPCTQFSPDSKIYSDEEELLYLSFMENVTDEILKLGLFSNRFLERLFERHIRKNKHHLEEGKMRYLLHGLKVDLGCISEEEQNSFRIFNEFHFQKALTSRENRFINDTEAVNHHERQQYQEALNMLSSVPKDENKMFSFPGEFLLPAHKVKHSEGVIVQQVNDETDFEALPWDGNNPSVSDSFIDQETSVDVIEGDSDFEMVETSRELCCLSTSLSPSVPLPSIEGGSNHDKELSTLKIMEMSIED
The following text describes a protein:
Function:
Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates. Type II pseudopilus confers increased bacterial adhesive capabilities.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MRASRGFTLIELMVVMVIISVLIGLAVLSTGFASTSRELDSEAERLAGLIGVLTDEAVLDNREYGLRLERDAYQVLRYDEAKARWLPVARDSHRLPEWAELTFELDGQPLVLAGSKGEKEQKKGTDQPQLLILSSGELSPFRLRLAERGPEGRALSLSSDGFRLPRVEVARR
The following text describes a protein:
Function:
RNA-binding protein which binds to pre-mRNA, spliced mRNA and spliceosomal snRNAs. Preferentially binds to the spliceosomal snRNP U2. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (By similarity). Positively regulates the nuclear export of spliced mRNAs including the sex determination gene tra-2. Promotes oogenesis by repressing germline masculinization and spermatogenesis. Required for embryonic development, possibly through positively regulating the expression of pie-1. Not required for the spatial patterning of pie-1 in embryos.
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus speckle.
Sequence:
MSDNEVEMEDVVANAERSRGRGLAQSRNRERITYDVVDEESSATSGAPQRSVEGWIVFVTNIHEEATEDDVHDKFSEYGKIKNIHLNLDRRTGFLKGYALVEYETQKEANEAIDQSNDTDLLGQNVKVDWCFVKGKKTSGKR
The following text describes a protein:
Function:
Needed for flagellar regrowth and assembly.
Sequence:
MSSSKASRIIKVDQSPNQAIRSYSFGFIAADAPQELPPEADGFVPFALGTPVPLPGLQSAEEPDPDPVVPFNLEGKVVLAEDELQARVDEVFRNGMDEGRRQAERGLANVFKSLRDGVAALTGLRSRVMKESEEDLLRLAVMIARKIVQREVAQDPQVLAAIVAAAVGGCTERDRVVVRLNPDDYTQVSANRQAFLAGLGEESAITLAPDESIGPGGCLVETATGTVDARIEAQLDEIYRSLLEERSAPVEPSASPDTDSRADLAFGGEETIAPFKGQGAWVKGSEEKPRDDV
The following text describes a protein:
Function:
This protein is a repressor of division inhibition gene dicB.
Sequence:
MLKTDALLYFGSKTKLAQAAGIRLASLYSWKGDLVPEGRAMRLQEASGGELQYDPKVYDEYRKTKRAGRLNNENHS
The following text describes a protein:
Function:
Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
Subcellular Localization:
Lysosome.
Sequence:
MAEWLLSASWQRRAKAMTAAAGSAGRAAVPLLLCALLAPGGAYVLDDSDGLGREFDGIGAVSGGGATSRLLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMHYALDENYFRGYEWWLMKEAKKRNPNITLIGLPWSFPGWLGKGFDWPYVNLQLTAYYVVTWIVGAKRYHDLDIDYIGIWNERSYNANYIKILRKMLNYQGLQRVKIIASDNLWESISASMLLDAELFKVVDVIGAHYPGTHSAKDAKLTGKKLWSSEDFSTLNSDMGAGCWGRILNQNYINGYMTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHYVVESPVWVSAHTTQFTQPGWYYLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHKHSKCIRPFLPYFNVSQQFATFVLKGSFSEIPELQVWYTKLGKTSERFLFKQLDSLWLLDSDGSFTLSLHEDELFTLTTLTTGRKGSYPLPPKSQPFPSTYKDDFNVDYPFFSEAPNFADQTGVFEYFTNIEDPGEHHFTLRQVLNQRPITWAADASNTISIIGDYNWTNLTIKCDVYIETPDTGGVFIAGRVNKGGILIRSARGIFFWIFANGSYRVTGDLAGWIIYALGRVEVTAKKWYTLTLTIKGHFTSGMLNDKSLWTDIPVNFPKNGWAAIGTHSFEFAQFDNFLVEATR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MDLDLNHEPMESSALGLGSLSNTRIEQRILHLEAVAARWRQVHNSAPDTAHNSANEAPNSAANEAPNSAADTGHNSVQHHNCLGKGKGCKRDRSHLVAKALEMDVVVKKVDKNGPSFFDCNICFDIAKEPILTCCGHLYCWSCFYNLPYVDSTTKECPECKGEVTDANITPIYGNAHSYCSKQVHSAFELPPRPKANRVESVRQQRVTRGLSHIPVAEALRRIRNSIGLGDHPQQLDTGGVSSTSLNGSQELQNTEATGSQRPRSRVFSRVLSEGAASLSSELENVQRLFEDITASITDRIHERSNLQVSPIGHVVADEGNSLRRDAAIIQSEHQTLDSIADASSVVSLPSSSQSNEVSDAALQLENLTTDTANLPVILSPYSRRRSGFSRRSDLDSEILPETRRRFS
The following text describes a protein:
Function:
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) using S-adenosyl-L-methionine as the methyl donor. TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLDMKEHPDAEVQKNQVLTLEDWKEKWVTRHISFHQEQGHQLLKKHLDTFLKGQSGLRVFFPLCGKAIEMKWFADRGHTVVGVEISEIGIREFFAEQNLSYTEEPLAEIAGAKVFKSSSGSISLYCCSIFDLPRANIGKFDRIWDRGALVAINPGDHDRYADIILSLLRKEFQYLVAVLSYDPTKHAGPPFYVPSAELKRLFGTKCSMQCLEEVDALEERHKAWGLDYLFEKLYLLTEK
The following text describes a protein:
Function:
May regulate the stability of some mitochondrial mRNA species.
Subcellular Localization:
Mitochondrion.
Domain:
The RAP domain seems to regulate mitochondrial mRNA levels.
Sequence:
MFRWSCAFRLSRSLLQTRFLSTDPLLDQFKICLSEDQVFQLVGKNKARLSVTHVGYAINLLWQFQKEKPRMLRTIGQVRGHPEFIALRILAENKIEFMDDKALVEILYNILRFNLEAHDSLVQQLVMEGWRRLERFNLTALSKFAVCLVEQHMNMSPLMGRIASIVDGTLDDVQDARILSSLMVSIYGVISPTLRDRLVDKADSLVDTLDVSHFNHPRRIVQFLRNMKYTYRPLLEKCNSVFLQNVGQMDPENLSIIIGLYQSLQFNNAEFRLMARARLIETMDQCSDVASYTKLFAALGPMAGQDIREKLEEGILTMADEMNPTQLLAILGTMEEMECRNTLLIAKISSLLQKYLESYRPVELARITQAIVTLRCQTPELFSMLQKILERLLKSSFIPADVSMLARVISTLPAARVDEEILSKVDAILPQCSLSDLSSLALAIVKWVRTDQPSRSSTSGGLGNLLLKLNTCGRERIAKIDKIDLFLDELKYTTGDWLEEVLLKDTISTCERLIDQVTWKNVPEFALFITRTNYLCAQVLDKIALVATEDITKIHYSATYATLLPFVVLNYDPPNGEAFFDACIQHFLPHLNSFDPHLVVLLAYSLALAEYFPEELIKAVFNVDFLGRLDAQLETFSSALNMRIRLRLMELNRAVCLECPEFQIPWFHDRYCQQLQHRANGGISSVQRQIHQLLGEILGGINYAKVSVMTPYYHAIDFECILDKNKKPIPYLDQNVLSADLSKVQWGNGGPLQETKSLPPGAQRVAIEFLDSKAFSKNSSNIKGEYVMKKRHLEILGYHVVQIASFEWNSMELSTKDAWIDYLRKRIFADDV
The following text describes a protein:
Function:
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAKQLIFGDAARQSILKGVTLLTDAVKATLGPRGRNVVIERKFGSPNVTKDGVTVAKEIDLKEPFENMGAQLVREVASKTSDVAGDGTTTATVLAYAIYKEGLKYVSAGANSMDLKRGIDKAVEAVVEELKKISKPVVDKKEIAQVGTISANNDVSIGELIAEAMDKVGKDGVITVEEAKGMATTLDIVEGMQFDRGYISPYFITDPERLECILEDAFVLIHDKKISTMKDLLPILEQIARMGRPLLIIAEDVEGEALATLVVNKLRGVLQVCAVKAPGFGERRKAMLEDIAILTGGTVISEDIGLKLENVKVEDLGKAKKIIIDKDNTTIVEGAGDPQKIQARIKQIKVQIDETTSDYDREKLQERLAKLAGGVARINVGAATEAEMKEKKARVEDALNATRAAVEEGIVPGGGVALLRCQKALEKIKFENHDQQLGAEIVKKALEEPIKQIIANAGVEATLIVEKVKENKNINYGYDAYAEKFVDMMEAGIIDPTKVTRTALQNAASVAGLMLTTEVLVAEIPEEEKKPPMPSPDMY
The following text describes a protein:
Function:
Involved in osmoadaptation.
Sequence:
MVRIFITGSSDGIGQAAAKVLSEQGHSVVLHARNADRAASAQEAVPGAEAVLVGDLSSIAETKALAEEANKLPPFDTVIHNAGIGYGATASQEITADKISAVFAVNTLAPYILTCLMHKPKARLLYMSSDSHYGGDESLRNITQSHSYGNTKLHDVMLANAFSRRWGNAIQVVSMHPGWVRTKMGGVMAPGALDRPARVLADWAIGKGDLARLKSGTFFTTSGPESAHPGADNVQKQEELLRICKEVSGVGVPGG
The following text describes a protein:
Function:
Transcriptional regulator.
Sequence:
MSVVSVSMPEELLERLDDFADDHGYTGRSEVVREASRNLLGEFEDKKLEGRELMGVVTVVFDYETTTVEEKMMHLRHEHEGLVASNFHSHVGGHHCMELFVLEGSLESISTFVGKIRATKDTLTIDYSVLPVDEFGGLADVS
The following text describes a protein:
Function:
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Probably involved in the resolution of chromosome dimers. Binds to the dif site.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLDLGSPPESGDLYNAFINALIIAGAGNGTIKLYSTAVRDFLDFINKDPRKVTSEDLNRWISSLLNREGKVKGDEVEKKRAKSVTIRYYIIAVRRFLKWINVSVRPPIPKVRRKEVKALDEIQIQKVLNACKRTKDKLIIRLLLDTGLRANELLSVLVKDIDLENNMIRVRNTKNGEERIVFFTDETKLLLRKYIKGKKAEDKLFDLKYDTLYRKLKRLGKKVGIDLRPHILRHTFATLSLKRGINVITLQKLLGHKDIKTTQIYTHLVLDDLRNEYLKAMSSSSSKTPP
The following text describes a protein:
Function:
Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Within the RQC complex, rqc1 is essential for the recruitment of cdc48 to incompletely synthesized nascent polypeptides that are ubiquitinated by rkr1/ltn1.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSRALRKLQRQRQTELLEEALDSESDEDDEFSSTSGKKVVNVFEILEKENNAINSEAEKSVSEEEQDEPLVEGESPIVSTNKKAKNKKKKKKQQKKKKVTGKRDLDNQSSDNEKLEGLESSKNIDDDIDEIEKAAAELKLKYREQDQVEHVAGVEESATIPLDKELDEKLNKLLGVNISMLNPDLEIRKIFGRIVEKRSVNARHDNLRRKRHVLVQPQEGWPPLVRSGLGMKLTGQSQDLECFFEITQSRAYQEVQETFEYYVQTYDPNNLLMLLRSHPFHIDTLLQVSEIIDQQGDHELSAELVARGLYAFDSILHPRFNLATGATRLPFAIPSNRRLFLCIWRYLQSLQSRGCWRTVFEFCKALLQFDMSDPYAIGTCIDIYALRRREFAWIIDFANYLENSNKISDTPNMLYSSALAMFYVHGDTTDTRASMLAAFERAPYMLSELLDTLNISFTKSSIPSPQDPVQELHSAMYALYAKDSWSDPTVLAFINSILEKETVTLHDVEGQFAELTENLSRRVILLNEQSLRKFLPQRILQGTILSFDPLPPDTYLSESQVFGRDISRRIASFLSDYLSRAREVNENEEEPPAHEFDLPPAEQLLQQIESEVGEESEDGTPVMTRLRSFFGSLFTSTNSETEPAEESTEEMGQGD
The following text describes a protein:
Function:
Could be involved in the negative regulation of root growth.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MSLVPPLPILSPPSSNSSTTAPPPLQTQPTTPSAPPPVTPPPSPPQSPPPVVSSSPPPPVVSSPPPSSSPPPSPPVITSPPPTVASSPPPPVVIASPPPSTPATTPPAPPQTVSPPPPPDASPSPPAPTTTNPPPKPSPSPPGETPSPPGETPSPPKPSPSTPTPTTTTSPPPPPATSASPPSSNPTDPSTLAPPPTPLPVVPREKPIAKPTGPASNNGNNTLPSSSPGKSEVGTGGIVAIGVIVGLVFLSLFVMGVWFTRKRKRKDPGTFVGYTMPPSAYSSPQGSDVVLFNSRSSAPPKMRSHSGSDYMYASSDSGMVSNQRSWFSYDELSQVTSGFSEKNLLGEGGFGCVYKGVLSDGREVAVKQLKIGGSQGEREFKAEVEIISRVHHRHLVTLVGYCISEQHRLLVYDYVPNNTLHYHLHAPGRPVMTWETRVRVAAGAARGIAYLHEDCHPRIIHRDIKSSNILLDNSFEALVADFGLAKIAQELDLNTHVSTRVMGTFGYMAPEYATSGKLSEKADVYSYGVILLELITGRKPVDTSQPLGDESLVEWARPLLGQAIENEEFDELVDPRLGKNFIPGEMFRMVEAAAACVRHSAAKRPKMSQVVRALDTLEEATDITNGMRPGQSQVFDSRQQSAQIRMFQRMAFGSQDYSSDFFDRSQSHSSWGSRDQSRFVP
The following text describes a protein:
Function:
Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress. When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins. Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes. Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes preferentially to endoplasmic reticulum tubules and sheet edges.
Domain:
The LIR motif interacts with ATG8 family proteins.
Sequence:
MAEAEGVPTTPGPASGSTFRGRRDVSGSWERDQQVEAAQRALVEVLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRLVFLLAFGLMIIVCIDQWKNKIWPEIKVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNVLLFKKQNPGKFCLLSCGILTFLAVLGRYVPGLLLSYLMLVTVMMWPLAVYHRLWDRAYVRLKPALQRLDFSVRGYMMSKQRERQLRRRALHPERAMDNHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTDNGTFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSINMDPAGLDDEDDTSIGMPSLMYRSPPGAEEPQAPPASRDEAALPELLLGALPVGSNLTSNLASLVSQGMIQLALSGASQPGPSGAPAQRATRGFLRSPSSDLDTDAEGDDFELLDQSELSQLDPASSRSH
The following text describes a protein:
Function:
Essential protein required during embryogenesis. Believed to act in part as a component of the putative HOPS endosomal tethering complex. HOPS is required for the central vacuole formation. May play a role in clustering and fusion of late endosomes and lysosomes. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Required for fusion of endosomes and autophagosomes with lysosomes (By similarity).
Subcellular Localization:
Cytoplasm. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side. Note=Co-localizes with VPS18 and RABG3F at subdomains of the vacuolar membrane with a small number of punctate structures in the cytoplasm. Sometimes observed at the vertex zone, the ring-shaped edge of vacuole-vacuole contact sites. Strong colocalization with VAMP713 at the contact sites of two vacuoles.
Sequence:
MVHNAYDSFQLLKDCPARIDAVESYGSKLFAGCYDGSLRIYSPPESSASDPSELHQETYVLEKTVAGFSKKPIVAMEVLASRELLLSLSESIAFHGLPNLETVAVITKAKGANAYSWDDRRGFLCFSRQKRVCVFKHDGGGGFVEVRDYGVPDTVKSISWCGENICLGIKKEYVILNTANGTLSEVFPSGRVAPPLVISLPSGELILGKENIGVFVDQNGKLLQTERICWSEAPTSIVIQNPYAIALLPRRVEVRLLRSPYPLIQTIVLQNIRRLVKSNNAVIVGLDNSVYVLFPVSIGAQIVQLTASGNFEEALALCKVLPPDESSLRAAKESSIHTRFAHYLFENGSYEEAMEHFLASQVDITHVLSMYPSIILPKTTIIPQPDKMVDISGDEASLSRGSSGISDDMESSSPRYFLESEDNADLESKKMSHNTLMALIKYLLKRRPAVIEKATSEGTEEVISDAVGKTYGANDSSKSKKSSKGRGMIPLNSGAREMAAILDTALLQALLHTGQSGAAIELLKGVNYSDVKICEEILMKSKNYSALLELFKSNSMHHEALKLLNQLADESKTNQSQTDVTQIFSPELIIEYLKPLCRTDPMLVLEYSMLVLESCPTQTIDLFLSGNISADLVNSYLKQHAPNMQGRYLELMMAMNDTAVSGNLQNEMVQIYLSEVLDLYAAKSAQQKWDEKDHPPERKKLLSALESISGYSPQPLLKRLPRDALYEERAVILGKMNQHELALSIYVHKLHAPDLALAYCDRIYESVTYLPSGKPSSNIYLTVLQIYLNPKKSAKDFAKRIVALGSFESSDTTKMMDSVLSSKAKGGRSKKIVAIEGAEDMRVGLSSSTDSGRSDVDTEEPLEEGDSTVMISEVLDLLSQRWERINGAQALKLLPRETKLHNLLPFLAPLLRNSSEAHRNFSVIKSLRQSENLQVKEELYKHRKGVAQVTSESMCSLCNKKIGTSVFAVYPNGKTLVHFVCFRDSQGMKAVSKTTHGRRR
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
Domain:
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Sequence:
MFVEYFKSSDHLFVPSSSVIPKKNDGSYFVNSGMNQFKPIFLGTVDQSSEMASYKRVVNYQKCIRVGGKHNDLEDVGHDYYHHTFFEMLGNWSFNDYSKAEACRMAWDLLTNVYEIPASRLYITYFVGSEKLGLKADEECKDIWIQLGVPKERILPFGMKDNFWVMGEVGPCGPCSEIHYYHGGGSADKARDFVNRGVEDMKEIWNLVFMQYDRQPDGSLMNLPATHIDTGMGLERLTALLQSKSSNYDTDLFRGIFNHISSLANVDKYGGSLVSKTDVAYRVVADHVRMATICIADGLMPGRKDSELLRQVIYRCLYQAQEVLKMPQHTIHSLVAIVVQSLKVSYPYLEENTKQIEEVIRETEHRYLCNITTGRKIMKKALNSQSCSENHKLSEGYFGSAVSYDIISLLAHEFNVSLDHDDYERCLSNINKAKPLAVSPLQPAPFQRPISLTQQDVMRLKEMNIASTDDSHKYVYTVDQQRDYGSIIVNFFILILRSCGIVLDRTCLYATSGGQQADLGHIVIVINEVVDVMNCAGYILHCFEGVSGTIRVGDHVDVCCSKVRLTNSSSNHTSTHILNFALRQVLGGPIKQQGSMVKDQFLTFDFSSVKATITLDDLREVSRTANEIVKKDMKIYRQVVPLDMVQNLPFVIKLDDDSYPKMVNVVSIGSPLDKILHLSSSSLYQLPPCSIELCAGTHVGRTGDIGNIVITNYEGSIQGSKRITAVTRDAANKALQNVDDARNKLLLISSSEDISKKLMILKDLDKSLSAGLLLPKIERENILEDLKNLNFELSQHKNKLSTFHIKQGLLERISKSKNECVICTYPISRTREVSNSSIFS
The following text describes a protein:
Function:
Transcriptional regulator that plays a key role in germ cell development. Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry. Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells. Regulates expression of STRA8, a central downstream effector for the meiotic program. Acts independently of retinoic acid (RA). In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase.
Subcellular Localization:
Nucleus.
Sequence:
KALETLGPSPLARDAKNMLTPVSQPSCSLGSPEAPPAPAALPRRRPRKQSKPHQGAEKVDPRFEGVTLKFQIKPDSSLQIIPSYSLACGSRAQAPSTGPAGGPEVNSGGAEALGPRCCASCRTQRTPLWRDAEDGTPLCNACGIRYKKYGTRCSSCWLVPRKSVQPKKLCGRCGVSLGPHQGPTQEG
The following text describes a protein:
Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MVHHLLVLVANVLIPIAVLVFSLGFFPYKPLISGLATFDSFEDRPPRVFDKVIFMVVDALRSDFVYSNNSGFLFTQSPTDFRSLIRSGAAIPFTAYAGSPTVTMPRLKAMTTGSVPSFLDVILNIAESDTSSTLAYQDTWLAQIRAKGEQLVMYGDDTWLKLFPGMFSRSDGTTSFFVSDFTEVDTNVTRHIHDELVTGDWSGMIMHYLGLDHIGHKAGPQSSYMVPKQHEMDSIVAQVYRAMEQEAHLQSTLFILCGDHGMNDAGNHGGSSAGETSPALTFISPKLQSLGAGRESPVNATHELQYYSVVDQTDITPTLAGLLGLPIPLNSLGVFIPEFLNMWHLGSQRIRLLAGNAKQLLNALKETYPNHNFGDDTLPASCYDDSPRGPDGALCAWAQAQELLHQYGADAADDIYVQTEIESALLRFLRSSQEVMSSAASNYDLRYLLLGICIAGLAVLFSIPATYKALSNHTLPRLFLTTGVLLYGAMMFASSYVEEEQQFWYWVFTGWTFYLHVRSIRLQKAPQGATYLLPAAILAISHRFMRRWNQTGQKFAAEPDIARIYLPSHRINLWLLIVVTYADVCLHLMDNLSSLIWRLLCLAVTAMCFTFKLVFAASESPELLNETTIQTVATFMDGITLVLYARVAMGGIAVLFMLIFMRNGKLPIKQGLFHEALTLFLLTQSRVTNVPIFLFFRLQLKALTWMNLNSAEVTLTSLLMQYIAFFAFGGSNAISSIDLSNAYNGVSVYNVILVGILTYVGNWAGPIWWISATKLLRRGESHDESRTHTALLTFHAASILTSVMAACTALRTHLFIWTVFSPKYLYTMSWVIIHHWVNLLLPTVGRQ
The following text describes a protein:
Function:
Serine/threonine protein kinase involved in the regulation of exocytosis. Induces phosphorylation of SEC9 and its release from the plasma membrane to the cytosol.
Subcellular Localization:
Cytoplasm.
Sequence:
MNNQDPDSQYHNKKVYPPNLPSIPPPPQQPLSGRPATPRMLRSISGTLKSKTELAHSDKGQESNNETKNSNSPHYVPDTHTRQPPPESLKSNIQAPTAVHGNQQKGSLLPPPSIPNPNTMKPAPTPTGVDQPPAKQKPSPAPKQPQPQQQQQQQQQQQFHRKSIGDWNFVKTIGAGSMGKVKLAQHNATHEICAVKIIPRAAKLYQRAHANDPPPQTTQEAAQRHKEFEKEVARDRRTIREGALGRLLYHPFICRLYEMVPMTNHYYMLFEYIEGGQMLDYIVAHGSLKERHARKFARGIASALDYCHRNNVVHRDLKIENIMINEKGDIKIIDFGLSNLYAPKNLLKTYCGSLYFAAPELLSAKPYIGPEVDVWSFGVVLYVLVCGKVPFDDQSVSVLHEKIKKGNVEYPAFLSRECVSLLSRMLVVDPTKRASLYEVCSHPWMNKGYDYKVNNYLPRREPLRLPLDPEIIKTIANFELGTVQGVADELTSILTSVEYQMSCENWYKITETGREYASSQNAQILPDPTGGFHPLVSIYYLVDEMRKRKKAKEEALKAQRRAQVPTIAVPTPKQQQQQQPQPAQPQPQPQPEVSQPLPEPKPVPPEEIINPAVATQAQANMTAPKIVETFSETPQRTLDPSKQSVDEKPSAPGPSIAVPEQAHTTSVPSSFVKTQTSIDEDQLSIPEQQSPRTSTPQTLDPAKVVGGSSGSAISAPNAGSGAGFNSLLRRLSSKKYKGASSPKRSTSPSPNVEGLSPQPTKADPMVRRGVSMKVTAKEKQTNTRPPKSELIKKKPQHGRSSSTSNKMQGFIPVEYLPPLPTIDTNTNTIVSDGAKQQNLTVPSTARHMHPTARAKSVGGGHMRKDSYGRVSHGSQNPLPPLPTSMASQNSQEVVGKDTSEGFFDDVQLDDVGYQEVPQLTESEIIEQYNISKPNSMPSIEHCKTLFLKGFFSVQTTSAKPLPVIRYNIINVLSKLGVKFQEVKGGFVCMHTPSVQPSHSNELDEENKLYGDAFKSKSSDSFEAAEPEGSKTPSRQPSLQLPSHTPTTPSGPKSHKSSNSIGSIGGNVPRRKFSIGNAFNTYRKKNGSQVMMPPNTPATAKVIHGLYDDDDKERNGEDDDDEDDYGYDDSADSLNGYGGGSDMLISSRIEQRAKHQRTVSSSSQKASKSPLKFEIHIVKVPLVGLYGVQFKKILGNTWNYKTLASQILNEMNL