lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKPGAKALGKRKAPASKPPAPKKAKAASAEDNTQVNGRPKRKPDQPKKVKLRDQKTIPVPKSVYATGSGDEDDGMGSDMLGNLGEEEGLGLENAAFLAGIDTTALSRSVKETKRLHELAKTREIIPQSKKQKSKTSVRQPGSDESDGFDSDPEFDSDLQSDMGSDVDLGSEDDQSLESDDEDEFSGSEDDVDVTAAFDDFSSDEEKDEPERRKRKKKEEEAEYELAGRSRWAAKPEEPEEDSVEVGRLPIKLPTGEIQMVQGSTRIAVPQPKKPVTKAESEDEETDEVDEEEENSDDGAQAMRMASQKGKFGRMGIAEIVGRKGWKNVQRLEAAKEQVAQLGSEILAGGELVDIGPVLTRLSSFGLPTVPALEEGQPPLSVPASIRGLVFLSQLAVYKDLIPGYRIRELTALEEAEKVRDEVKRLREGEKMLVKSYKGYLKMLEAEIKSKTNLATISLRCMCELLTSVTHFNFSENIMGVLVGRLGRRSWDGDSDLVLQTFIRVFRDDISGQHSQTLVRLIARMIKERHFQVHPNVLFCLLHLRLKDELDQMRRGKNAKGSNKEKGGKDEIKGKKFKSEKRKKWATKNQKKREREMKEVQKEMAEAEAEVDKEERARVQTETLKNLFVLYFSILKNPKRTPLLPAALEGISTYSHFINIDFFRDLLVVLRKIIADQQLSDATNKQEEESEDESSQQLDVVGASQRIRNRLLAIATAFDLLSGQGEALNIDLSDFINQLFSLLRPLCLDTGIEDPPFLPASTKSSSGAVHTLSTSALLFRCLNASFFSRHSRSPANRSAAFAKRLTECALHFPPRTGKQAIAFARSLLSKEPKIEGLLDTEERMADGAYRPELDDPQLVNPFTTSWWEAGVLGSKHWDREVRLEMSKLRDGKVV
The following text describes a protein:
Function:
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKKPENLSFEESLGELERIVAELEQGDVSLDDALKQFERGINLVRNSQAKLEQAQQKVAILLKQDENVPLSPYAVEGESAC
The following text describes a protein:
Function:
Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.
Sequence:
MLPRLFSVRVWAPVGVLTSLAYCLHQRKVDPQQLQLKMVQVVFRHGARTPLKPLPQVEQVEWNPSLLEIPDKTLFDYVVTDLEGGPRPPSPYDSQYQETRLKGGVFAGQLTSLGMQQMFSLGERLRRNYVEDVQFLSPTFKPGEVTVRSTNIFRNLESTRCLLAGLFQRQKEGPVTILTDEASSEILYPNYDNCQTLRYMVSVRRLMATVQPEFLEDLKKVQSEMGIDGSKGVDFFLLLDNALAEKVHGLPSCPTLKKFTRMIEQRAVDTALFILGSRDREGLQMAVGPILYTLQNNMLELSTPSALPKDTRKLYLYATHDVTLMPLLITLGIFDHKWPPYAADLIIELYQHKKSKDWFVRLLYNDKVSPRGGPGIRAGSPPVPESETRVWPFLLPLAWVTRGEHGLSETILIASERPAGSLSQGRGPALERWTGWFGGWLAVGQGIGGRS
The following text describes a protein:
Function:
Subunit 8, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MPQLDTSTWFTVILSMIISLFMLLQLKISSHSFYLDPKTMSLKTTKHNLPWENKWTKTYLPLSLHLH
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
Subcellular Localization:
Nucleus.
Sequence:
MPAAGHPATLATLLLCILLSAMPAANHAHPFQLADLVGPNAASTFFKNFYRRNYLHISRHLDSLMPLDSWFGDLQNIDVFMTELYQQLYDDSALSFKTANSTKLPFPKAATWMDYSDQFYRSGQSAVIRREHMSVSKEPIEMLISDVFGSPEVTAHAYISAGQAHALKPHTDPSVPLPPGVCCPLTRLPPVYLTSLCSAMVAMTFLWFKSLAKKNGTYVKLSTVVRLGPRLHRQN
The following text describes a protein:
Function:
Proton oligopeptide cotransporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MFVTGFIINDEKAPLPLHGGPERQKTVGHLGCFRVGICSLLVELCERFTFFEVVCNMIPFCTRRLGCYNHQAAILNLCFIGASVLTPVFMGWLSDSKYLGRNKLVYIAVFLHFLGTALLSVLAFPSEDFYGGTSPASNMPMKKRAGLFHVALLTLCLGTGGIRAVVCLPDACGHWEQESKKPMSFCNWASWSMNLNTAVVFLGVSSIQLLGSGAVMILLPSLSVFTASVTLYMTYCDLIYEPENHCSLPTVSRAFARVLKTRCLLYCHLGRAGSSWLARAMAKQGVCHCELQEEETENVFSALLSLFSFQLIYRMCLTQIPSGYYLQTMHSNRTLGGVPLPIALMNAISLLPLLTLGPFMDFFSNCLLPSKRDGPFLSVCIIAGNICAAFSVAVAGFLEIHRKLAQEQSPSGKLSSVSSMACVYLVPQYVLLGVSEVLVNPAVSTVTRRVVPSTFRRASMTCLTLFHGSAYFAGALLIELVYLISEGNWFPNTLNKGNLESFFFVLASLTLLNILGLWRVLPRCCNLNHFNAQRIHGNNCEETLLLSEKSLKFYGSTQETSSSIDLRETAF
The following text describes a protein:
Function:
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).
Subcellular Localization:
Nucleus.
Sequence:
MMAAKGNAFSVMMNAQKRKLADGAAKTAAQPAKKGHWSMGLLSSMEDPALKVDSDDKVVIIKDKYPKARYHWLVLPKENISSLKAVSAKQLDLLKHMHKKGQELIDKTEDAKHLSFRLGYHAIPSMSHLHLHVISQDFDSPCLKHKKHWNSFTTDYFIDSTDVMEELEKEGKIADKGSRNERLKDPLRCHVCKKEQVNMPKLKAHILSHIPKPGDKK
The following text describes a protein:
Function:
Downstream effector molecule for Rab11 GTPase which acts as a regulator of endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery.
Subcellular Localization:
Recycling endosome membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Domain:
The RBD-FIP domain mediates the interaction with Rab11 (rab11a or rab11b).
Sequence:
MEQVLSSPQGCSEWEVNGKTEWESDQNPLGFLLVDKENSSVADPTNEIFQENAINLDDLFWASQTYSWENGLDCVYPEWKAQPPPSQDLKGDGNSGISQLVEGDLICFNSRSASPSLADRPVQDNNLYDHAEQVEVTATSSTLNVCTGELGINAPTLHTDKTLLQDTHLMLEESHLTNCEFSCNSGVENESQNFLSHGTRNILESEGLFAVSPVEVSCVDTNSNPKPTIVCQTPPLASEHIYLSSSALPCEPVFPMTCTKPHVPPYHAGSATLPMDEVEMMLPKLQGGEGESSKPSANNRTLEPQRLDANTDTTHLSVCPLGESDISPEHCEEMLHELSTKCTVEMVEEEVNKKSVSSNTTNTAFSKPKTELCEELSGCTLGVLLETVSGDVKEEAASDSRTDHVFPETQTDLAPVALIDSQAEDPSTESLPRKNGQEESKSALPVSTPEHNALFELSSGNVVLPEDHSQSTFSAQTQALSEVDHDGDLTPDGMLTDNIVCEAVTSIDSVILSLTDSFELPKLSDCDLSSHDFESHALTLEIQNNVTCVQTGSVDNNPEEMSTPFTCTDNQLTVTGGLAGLDLTETTSQSGEASGEGEAGLPVLPTHQEDFHQLTPSEINLAQEQQVSSVVPSSPPSHRDVFPCGASLDGEAYLTLMENNPDTLKHAEMTLDLCKASDALPTKSLQIAPVDLIHVPIVSATAPRSEEQSALRAVFQALDQDGDGFVHIEEFIEFAKAYGAEQVKDLTRFLDPSGLGVISFEDFHRGISAISNEESAYSECETFTDEDTTALVHPELHEDVETDSGIENTLTDGDDRNSPSSFPASFQNFLQSEALEFFCTHCHKQISRLEDLSTRLQLLEMNRHLQQSNNLDVMGDLTQDILDLADRDITDKVLLLEKRVCELEKDSLESEEQHARLRQENLTLVHRANALEEQLKEQELRTEEDLLAQTRKHRDALNKLQRERDLEIENLQARLHQLDEENSELRSCVPCLRANIERLEEEKRKLQDEADDITQRLNEESESRRKMSDKLSHERHTNQKEKECTQGLIEDLRKQLEHLQLFKLETEARRGRSSSNGLQEYNTHMRENELEQEIRRLKQDNRSLKEQNDELNGQIINLSIQGAKSLFTESLSESLAAEINNVSRAELMEAIHKQEEINFRLQDYIDRIIVAIMESNPSILEVK
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGEMFRGKDMSLGQLIVPSNIAIETIERIGKLGIIQFIDLNDNLASFDRRFINEIKRCEEIERIIRIFEETISFEESRDGFNKIFKRNSLAVDLLPIATADAQQSELSSEQLILKIRTFDNDLKQLTSDVAAAERAVSGIHEAISLSEHINELIGQDIDQTTAQTLKYLIGTIDTSKWEALRMVIWRVSRGFVVTRSAPIDNRKTGFVVFIQGDEVLNKLNQICLTSSARIFDSMPIDVIERINYVNEKRQELNELTEVLNGALEAKRQCLRLIASDINIWNEVIERERQVYFTLNMFYVDEGHSHLCGEGWFPTDQFSEINRALEEIEGPVKPLFGVIQPHPNAIPPTYIPTTSFSQCSQDLCDSYSIPKYGEVNPGFLYIITFPFLFGVMFGDIGHGIIVFLFALLMIIFQKKIELTKRNEIFDMLFGARWMILLMGLFSIYCGALYNEFFGIAIDLFGTSWNKENGLFYERSNPNYVYPFGVDPIWKSSNNELYFYNSLKMKMSILIGVTHMTIGIWISLINHIHYKNLINVVFQFLPEIIFMSCTFGYLCFLILIKWMFFIEDAPMITNVFLEMFQNFGIVTEPNHMFWGQSFIEPILFIFTVLSVIAMMVPKPILLYVLKKKDQKRSENGQGQDNYYQPFNQENNDFITEDIRQENNDIPYLPNENDGYIVANNNIEEMQEQFENEDRVSLLGNENKSIKKENLLSEESKISKILKLIKKKNPNYTFDEKEWIRVKYDPDDENGNNLLEIIIFNTIHAVEFILGCISNTASYLRLWALSLAHAQLGSVFLEYVFYTLLEFNNFFLTFVGFALFALITLGILIGMESLSAFLHTLRLHWVEFQNKFYLGDGIKFVPFKLSTNKKLFN
The following text describes a protein:
Function:
Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.
Subcellular Localization:
Vacuole membrane; Single-pass type II membrane protein.
Sequence:
MIPYLFLQGILVASVTALPVLEQLPLGLAVPESNSQSDGGIYLEKSRRLHGRFLHITDLHPDPYYKPGSSSDDGAPCHRGKGSAGYFGAEGSDCDSPFSLINETFSWIEKNLKGNIDFVLWTGDSARHDNDQKIPRTEDEVVRLNEMLANKFVDVFRDKQFPNGLSIPIVPTIGNNDIMPHNIFREGPNRWTKRLQKIWSKFIPEHELHTFVEGGWFTSEVIPNKLTAISLNTMYFFDSNSAVDGCKAKSQPGYEHMEWLRVQLQLLRERGMKAILIGHVPPARTVSKRNWDESCWQKYALWVHQYRDVIVGSVYGHMNIDHFILQDHHNANIVDVDLHETSLEAPNDTTGDISIRSRSAYLSDLRHDWAKLPSPPRDFPMDNSTLDDWFGEGATFENDDDIQFKKSKKKRRQFLKEIGGPWAERYSVSLVSPSVVPNYFPSLRIVKYNITGLEDINAWAGTSVGADILLSLTEKSKERRSQSESIEDPDVDELEKRKDKKKKKKKKKKKPSFKVPEPPSPTAPPGPAYSNQPLTWLGYTQYFANLTKINIEYYERYGFSTDGLVNETSGNDIFTFEVEYDTTKDDMYKLADLTVRSYFKLASRIAKKASTKDQMSETGATDDLHAAIDNDGDDSRNMKDTKGKMMRNRVWKTFLKRAFVGYYKGDEIDD
The following text describes a protein:
Function:
Exhibits fusogenic activity. Mediates cell-cell fusion in mammalian cells when present in both cells (bilateral fusion).
Miscellaneous:
MISCELLANEOUS: This entry represents a metagenomic sequence isolated from an uncultured archaeon from a hypersaline environment.
Subcellular Localization:
Cell surface. Cell membrane; Multi-pass membrane protein.
Domain:
The extracellular N-terminus has 4 domains; the first 3 are structurally similar to fusogens from plants, C.elegans and viruses, while the fourth domain is unique to archaea. Domains I and II are discontinuous, domain IV cannot be replaced. The protein can be anchored to the membrane by either a different transmembrane helix or by a GPI-anchored construct and still directs membrane fusion. The fusion loop in domain II is stabilized by a Ca(2+) ion so that it protrudes from the molecule.
Sequence:
MRRAALILAFVLFIGLSSATVTSADSITYNSGTSEFFDGDVFAIEVTADQSTDEIDIYLGASELSEKTDGEVNQDLSIEFTHQDSKLKYSTSTSDELRDIVTLTTYYEDGFDTEQDAIDAIKSDCYDLNQNGNGSGRYSRYYSVTSPVYDYEIYCFQKNEKLATPAYIDNPDEIFTAKAELQAGDKTIQSATLSNGDAGDGTVTDLGDSKISWNGNLDLGASEPENSRVIALYSNDFENGWRIGNKQSYEDYKTFIGGGDAYDLLIDWQDGTYTASEVEDELVNTDANQAVEEASSSTTDLVNAKVKDSSLDTGSFVYDTPELLSYPSFTVYVDAGENGYIEVTKPTGDPDIISTSSTEIKEGDEGTVTATVENVGDGEGEFSGRLSSCGEGFSIVDDQNTKNVGAGESVTYSFDVAFSSVSSESKEISGSCTFEVNGVESSDSTSVSVTGIQQSECNPGDQRREKNENDRWEIYTCQDNGLTYEYDVTCAEDEKAVAQGDNQFSCEKQDDDSGGGDNTGSDSGLFSNLFGGSGSGDLLTQVHTALSILAGLVAGFFGYRGARWIHGETDIKGGFKLESRNVSRVKRGSPVAGIVGAVLGFVVGYGVASVFHPVVQIIVVLGIAVGLYYFR
The following text describes a protein:
Function:
Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
Subcellular Localization:
Endosome membrane. Microsome membrane.
Sequence:
MALTTTSQSAAELGKACPENNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNRFDLVGFIPLLRERIYSNNQYARQFLISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANILVIHCQTTDDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKKSIKEVANVCNQSLMKLVTPEDDEPDELKPVVLRQAEPNPDDSLVKQEGTVSGGPSGSCDSSFSSGISVFTPASTERAPVTLHLDGIVQVLNCHLSDTAIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQTLSDESDEVILKDLEVLAEIASSPAGQTDDPGPLDGPDLQVRHSELQVPPTGRAGLMNTPGTKGLECSPSTPTMNSYFYKFMINLLKRFSSERKLLEVRGAFIIRQLCLLLNAENIFHSMADILLQEEDLKFASTMVHTLNTILLTSTELFQLRNQLKDLRTLESQNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLTEVDKLVQLIECPIFTYLRLQLLDVKNNPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELLQTEDSLKAAPKSQKADAPSIDYAELLQHFEKVQKKHLEVRHQRSGRGDHLDRKVVL
The following text describes a protein:
Function:
Transmembrane receptor that binds the molecular guidance cue Sema2a, to regulate axon guidance and possibly salivary gland positioning in embryos. Acts as a receptor for Sema2a and seems to transduce signal by suppressing Rac activity and enhancing Rho activity. As transmembrane receptor for Sema2a, involved in peripheral and central nervous system axon guidance. Function in neurons is essential for adult survival, motor neuron survival, and is important for climbing behavior and activity. During embryogenesis, plays an important role in correct salivary gland positioning.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MLRKELYCANIIHVLHVLCIIIILGSQHYCVNCIEELPAQALSPLNDIVAQFNLPSIPVQSTASSYGNRSIGNNIESVRDSQSKNYFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCHAGGCPEDIETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSLPRFPATPQFFAVPLAANDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRLDDLNYAEFSIQQSIINIDVKYRDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARICITDPNYDSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPESKSAMCIYSIKDIEDMFIENIHLCFNGTTKDRNLGYISGTINDGRCPIVGSLGNIYNFCSVGLKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPGEYEEIVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLPEPFNAKYRCVFGNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSHHGNCQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTHEYQAKVVVTWNFQHYVDTAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNSCVYNETCIADKNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCELENYQISVKIECRTGASLYEMSAPIKVANDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFYDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRNLNKYFHDIRSTIVYLADPKYLPFPNDGVKLYKGDSLVIEGELLNLAADEYDVNVTIGTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLVGILTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAELQTDMTDLTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNSPKFREGSPQTNYDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASKHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHILQDDLDEKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKESAVMSLIARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPRVYHLVKPNIPDHYMNIKNSVLSGGSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTVNEELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLSVIAQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLSVRQNEEFDTISALKELYIYITKYKDQIMESLETDINCRKMHLSRKLGNVAATLDGDCTSNC
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MNNTNLVIIWILIITIIVPIKSNKGTDRPTNVGLANYCTILSIDGGGVRGLIPSTILAFLESKLQEIDGPNARLADYFDVIAGTSTGGLMTTMLTAPDYRNRPLYAARDINGFYFQHSPKIFPQLSDDDDTIISEKFSTQHEACDGRIKFLNSVAGMFGEVAGPKYDGKYIRSLTKTLLRNMTIKQTLTDIVIPAFDIKHLQPTIFSTAQAKEIAWKDAQLADVCISTAAAPTYFPPYYFETRDTDGTKHTFDLIDGGVAANNPTQLALTHIHKEVLMGKYRFAGATSNHVDAKRMLVLSLGTGMQKFTERYTAQKAARWGLLRWIFDNGSTPILHIYSDASSDMVDIHVSTLFRALNAEKNYLRIQEENLTGDQTSVDISTMENMKALENIGKKLLQKNVSRLDVESGKFLEVKGAGTNAEALTHFARQLCAERKRRRCTN
The following text describes a protein:
Function:
Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3'. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17. Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus.
Sequence:
MPSDFISLLSADIDPSSPKSLYSKESVYDLLPAELQLPSLVQQENSSMSQKSGGEAGPPPAAAAAALPTDAAAPCAAASSPGALSSTLPSCPSMLSATSAPEQTPEPQPERMEPASDAAQSQATPSKRRTVLSISPPPEDLLDDSRMSCQDDTLPNLDSEQSSTIWLEDSVSNFSMGSSSSYNDNTEVPRKSRKRTPRQRPGSKPAAREEAGMDVFDADSAKAPHFVLSQLGSDAKVTPKASSLEVSNNQKGGVLSIQYPPKSEGKELKILVQPETQHRARYLTEGSRGSVKDRTQQGFPTIKLDGVSDPVVLQVFVANDAGRVKPHGFYQACRVTGRNTTACKEVDIEGTTVIEVNLEPTNSMTLPVDCVGILKLRNADVEARIGVAGSKKKSTRARLAFRVNIPRPDGSILTLQTLSSPILCTQPAGVPEILKKSLHSGSVAGGEEVFIIGKNFLKGTKVLFQENSSDESGWQAEAEIDMELFHQNHLVVKVPPYHDQTVANPVSVGIAVVTNAGRTHDLQTFTYTPLTEKVEIPVKSELPATVKACTFEEQIKAMQTETSCLNNVIMLPMVKREEPMEVSCNATPSDIFKPVETLSSTQQILEISTVLPSATKSFPSPVALQPVDSQQAPAQIFTTQETLATIQKQDIPSPASFQVSLSEDTTVLQPVPPQVPQQSLRETPETLSPEDSSADGAGMVLVGIDRNPPSQRQQVQALLPQDGVAQLELAVRELQAQQQLNSVLYSPTPSAESLQQHVQENMNSLRLGGNETTLTNQQQQQQEQNILENLQQQQQKALVDLQHQQTVLENLQQHQKVLENLQQHAMGNIQQQQTHKVLENLQHQQQHQRVLENIQQQSSIVTLQHQKVLDNLQQQQQHQINLETLQHQEVLESLKQQLQSELMQTQIPMQCTPSFTNDQQSSTQASTLPQSSDGFLQNPPQQQAALFQQTGGIMTIQTSGFLQQPSAQPSPPQPLFQSHNPLTETQDTQAVLFGATKPPQVQAALFPSTMTMLTSSNLPTEQQPPSASLFIAQSVLPASDNTQNQPPQQITFLTPMQTSGAEPQTVSLFQGQTQLSTPMEQQQSPQQQQMPTSQQAPLFSNITTISPNQAQQPTQTGILFCTTTINPHDLPQALLFSGQNQASLGTDRLPENIFQEQQPMQVVPSSENVSSNNPSNQPAVPAAQAAQNPSIIFTQTGVVNVAQQDSAEPMSFQDQSTGVNESSASLPSTRTELFQDQQPMQVVPSAASVTPVSPSDQPSVNIYLPPSAISALQGGVSAQDLPPAAAAATMFSGQTGVSGLQNAAPTAPPQPSSQLFQTAIGGTLSQPGPPGPAGLFLFEIPSDCGTLINSPGPPLSDQLVTLGHPGADQNQTQLQTNAQIQTLLDPSSNLEDKIDQLLESFQEQGKSLPQDFLDH
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MSRSIAPLLCIFLLLATSSASAFNITRILGQYPDYSTFNDLLSKSGLATDINKRGTITLLAVPNGAIGDLASKSDDILKRVLSTHVVLDYYDPMKLQRMKEKTAKMTNMFQQSGTAAYDQGFLNVTAKDGTFVFGSAVVGSVRDSKLEKSVMNQPYNVSVLGISKPIVTPGLDGTMAPISAPPPKVPAPKKSPVAESPAEEEEAESPSQEEEAESPSEEAESPSEDDDDADSPAPSPNADSAPADAAPPPSSAGKLKASFGLFVVLASVVAAY
The following text describes a protein:
Function:
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTGFNAQSFLRTVTSSAGVYRMYDVKGDVIYVGKAKDLKKRLSSYFRKNLGNVKTQALVSHIHHIDVTLTHSETDALLLENDYIKQYMPKYNVLLRDDKSYPYILLSQHEHPRLAYHRGPQREKGHYFGPYPNGGAVRESLHLMQKLFPIRQCDDLYYKSRTRPCLQYQLSRCSAPCVGKVSNAEYDEQVKLASLFLKGKDKQVISELVAKMEEAAEQQAYEQAARFRDQIMALRRVAEQQEVSGNTGDMDVIGVHYASGIACFHLLFIREGKIFGSRSYYPTVPAQTDIEEVLRSFLLQFYLNADIQRTIPKEVVISHHFEELHELEAAVSEALNKKFSIKTNVRADRASFLRLAITNATNAVMTRLSHKNTVEQRFVLLEEILELNAPIQRMECFDISHTMGESTVASCVVFNREGPHKAEYRRYNIEGITPGDDYAAMKQAISRRFDKIDASGKIPDILFIDGGLGQLRIAQQIVDEKFVNLDKAPQLIGVAKGESRKPGLETLIFGDTETSFSLEDDSPALHLIQHIRDESHRFAITGHRNRRQKTRNTSTLESIPGIGPKRRKALLQHLGGLQEVKGASVAELAKVPGISIEMAQTIHDALRG
The following text describes a protein:
Function:
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAGREGSPPSSQAAYLSGGNAASEWQRWRVQRPGRLSRGDGEVIGKVDEIFGPINEAYFWIKMLEGIIATWYLPGDKLYIDSAKLLPSTRFLPKPKYDNSSLFSFCCLLTTTLLSQHDNVAMISWYAAIHELNIEFYFIV
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Also interacts with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction. Also promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function.
Subcellular Localization:
Cytoplasm.
Sequence:
MAWQVSLPELEDRLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAVDGSSSPPNVSLARVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPVSTVYSRMKEELAALIAELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHEFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAPEPLKLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASCGFSCGRHYWEVVVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPPSGPGPLSPEQPTKL
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAISTTPTSFFLIAILVLLVPINHSFSSSSNGGDILSELTDLRSQSPTGVIHLSDQLLRRILTVKTPRPFNFVIFFDAKQLHSKPELSLPTLKNEFNLLSSSFYTNNPENDKLFFFTIEFQESQTSFALFGVNSLPHLRLIPPSAIDLKKDSIQMDGSDLARLAESMAEFVEAKAKINVGPIHRPPMISKKQITGIVALGLVLSPFLVKKIVSGDTIFHDKHVWMAGSIFVYFFSVSGAMHNIIRKMPMFMVDREDPGKLVYFYQGSGMQLGAEGFAVGFLYSIVGLLLAFMIHVLVRLKSRTVQRVVMLFALFVSFWAVKKVIHLDNWKTGYGIHAYWPSSWN
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MAECPGHFGHIVLSKPVFHAVFLPKIIKVMRCVCFYCSRLLVDPELPKMKMILSKTKSDFNRRQNLVYNLCKVKTTCECRSGDVETGEKMEQDVQVEGCGRHQPKIRKIGLELTAEWNVLNHESQEKKIVLTAERVLEIFREITDETCSYLGMDARYARPDWMIATILPVPPLPVRPSVLNFGAARSQDDITYKLADIIKINNKLKRNEEQGAPPHILDENIKLLQYHVATMINNEMPGQPKATQRCGRPLKSITERLKGKEGRVRGNLMGKRVDFSARTVITPDPMLKIDQVGVPMTIAKNLTYPELVTPFNIDRLTQLVHRGPNNYPGARYIIKQNNVRIDLRYHRKLSDLHLQIGETVERQMLDDDYVIFNRQPTLHKMSMMCHKVKVLPYSTFRLNLSATTPYNADFDGDEMNLHLAQSLETRAEISQLSSVKRMIITPQANRPVMGIVQDSLTAVNKMTRRDSFIDKKNMMDLIMYIPHWNGKIPQPAILKPEPLWTGKQLFSLIIPGQINCIRTHSTHPDDEDRGPYKWISPGDTKVIVENGQLLSGILCKKSLGPSSGSLQHIIYHELGREATGDFYSHVQMVTNQWLLTEGHSIGVADIIADYKTYMDIQLAVMEAKANVADITYKAQKGELELTPGNTFIQTFENQVNRILNDARDQTGRLAQDSLSDFNNFKTMVVAGSKGNRINISQIIACVGQQNVEGKRIQFSFRDRTLPHFLKNDHGPESQGFVENSYLAGITPTEFYFHAMGGREGLIDTAVKTAETGYIQRRLIKAMESVMVKYDGTVRNQAEELIQLRYGEDGLAGEWVEFQNLPSLKPSDKAFEREFKFDLFNEKKLKRCLYEDVLRDMHRDANFSFEIEREYEQLLDDRMAVRQIFPNGESRVVLPCNLQRMIWNAQKFFKINHKRPSDLNPLKIIKDVRELSKKFMIVKGEDRLSKAANTNATLLMNILMRSTLCSKKVIEEFHLSSEAFDWLIGEIETKFTQAQVEPGEMVGALAAQSLGEPATQMTLNTFHYAGVSSKNVTLGVPRLKEILSISKKPKTPTLTVFLTEQVAKDAEKAKDVLCLIEHATLGKVASSSAIIYDSDIRHSVVKEDQDWINTYYDLPDIDLNRLLPWLLRIELDRKRMTDRRLTMEQIAEKITAGFGDDLNVIFTDDNAEKLTLRIRLNKQADKENQETVEDEFDKITDDKFLKLIETNLLKDLTLQGISNISKAYLVHPTSDEKKRIIIDEKGEFKTIQEWILETDGTNLRSVLTVENVDHVRTISNDIVEIFDVLGIEAVRKAIEREMNNVISFDGSYVNHRHLALLCDVMTAKGHLMAITRHGLNRQETGALARCSFEEMVC