lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus.
Sequence:
MSAKLHPSRSLSARGRRGDGCTVLQGRLLPVKDGEVAHKREESDPDDSDGDDPQFMDAREIEGGGMVVQSTPLRRTVVIIKDKYGPEYRVSGFFPLVDPWWSVKLKVKRDGTQYFAQGYPSYALENDMSKDILSLFLHACKVHDDTKQTFINWLPSDATLTFDNLKKLIEEFQMNNSSNKINIESSGPGLLVMQALECPLTLKYLPKLLPRKVKGIFFIQTSESSEDPKPQIDLLKEIETILASEPWKFGFQCIIYRALKLCRCEATWGCFLQCKKLLAKMTELQKNALLIYNELKDRCREIGDTYAEQEVLTKLVSGQMPAEDAWEAIKFLKDNCIVVLEGQRVFLQNLYLYEKDIARYISALVNGTSWKLDFDAKEILASTKCFAGEENSKLEFTADNPGNLYKDDGPPSQYINTLQITDGPASTDDSSAELDIDQLNAVSMICSNPITVISGKGGCGKTTVVSLVFKHMIKKENMEIEEACKALEGDLDASEEWNRDQMACKEECIEPVHILLTAPTGKAASLLKKKTGLPAATLHQVTCSYSAWRKQNSDKPWKFSKVKALVVDEGSLVSVNIFSTALKFLCNNSDLAKLIILGDVRQLPSIEPGNLLADIFTSLGNKKWVIELRTNHRAESQLIVDNATRISQQKYPEFDAVINIVSGQAIEMPDAEKKFILVSLSSGNDQDLDTAIKALLDKGPGLEDDKHSQFIAFRRRDCMMINELCSRHYSEHSIKNHKNKFDFQVKDKVCCTKNAYVKDLKTKNTERLDLTQSPGNRHTINCEEAIPSTAAWARNRSQAQSDSLANEDERLCNGEIFFITDDVERDKIRELTLRDSEDREYTLNYKALRRCCGLTHAWARTIHTFQGSEEETVVYVLGSAGRQNWKHVYTAVTRGRKRVYIVAKLDQLGGAIANKARDRKTRLQQRLKETLTQNRDDPGSGKPIGGTQVQCVSNADHEDCNREQKFKILSHHSPTSPGCSVPSTAPPNCEVPSTSTNHTEGNLASEDFIHSLQQSPSQKRPANISEGPGTPAKLSRVAASKENMSPLGCSRLQNLSLGCSSPKQLFKP
The following text describes a protein:
Function:
Involved in hh/hedgehog signaling. May act as a tumor suppressor in larval imaginal disks.
Miscellaneous:
MISCELLANEOUS: In strains Harvich and Apxo, there are 2 identical genes which code for l(2)tid protein.
Subcellular Localization:
Cytoplasm, cytosol. Mitochondrion. Mitochondrion outer membrane. Note=The 50 kDa and 40 kDa protein products TID50 and TID40 localizes to the mitochondrion. The 47 kDa protein product localizes to the cytosol.
Sequence:
MMISCKKLFVFRQLPAVRRCLAAAAFSTPRATSYRILSSAGSGSTRADAPQVRRLHTTRDLLAKDYYATLGVAKNANGKDIKKAYYQLAKKYHPDTNKEDPDAGRKFQEVSEAYEVLSDEQKRREYDTYGQTAENIGRQGGGFPGGGAGGFGPEGFSQSWQFRSSIDPEELFRKIFGEGNFRTNSFDDFADSKFGFGQAQEMVMDLTFAQAARGVNKDVNVNVVDQCPKCAGTKCEPGTKPGRCQYCNGTGFETVSTGPFVMRSTCRYCQGTRQHIKYPCSECEGKGRTVQRRKVTVPVPAGIENGQTVRMQVGSKELFVTFRVERSDYFRREGADVHTDAAISLAQAVLGGTVRVQGVYEDQWINVEPGTSSHHKIMLRGKGLKRVNAHGHGDHYVHVKITVPSAKKLDKKRLALIEAYAELEEDTPGQIHGIANRKDGSKQATAGASEEPGAGAAAKASAAAAGSGASKPGPGAEESEGKDQWTDNKKTKAKEGGGSGSGQGDGGGGGFISKIKSMFN
The following text describes a protein:
Function:
As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication.
Miscellaneous:
MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
Subcellular Localization:
Nucleus.
Sequence:
MNNSITDSVEKKPEQVSFEVQPNALRPVAFHVFTRKYDLNINRDSLQELASFVSKKCGSQWRSQCEPLLDEIAKTWKRVHETQPIVTRPLLIPVLANLNVPHEVRVSSLARVQTLETTGSFLNSSNSEIRETIKNEKYFRVLDAFKMPKFKYDSSRKVFVLSKQSPTLMASASACTDMLNRRFNVVYSRILRNESFQTPSFSGSFSQTGTYQLTPIRNLLGRAGNTFLLFGLLTIAPDGTLWLEDLDSQVQLDVSQAEQGFGLFCPGCLVLVNGQFLSSGLFLVFELGHPPIERRDASLKALNNLDILGLNMDAKQLALLRHAEQAYQSQAFVCISEVHLDNHQTFYALEKIFQKYESSEAVPFCIILCGSFMSSAFHNSGSSIQYKEGFNKLAASLEKFPKICEKTKFIFVPGPNDPWTTNGISLMPKHSIPLHFVNRIQRVCKHTIFASNPCRIIFFSQEVLIYRDDISGRFQRNSLKFGKTPQGTSNINSIPLAEQQVHQQRKLVKTVLDQSHLSPFPSRTRPILWDFDYALSVFPLPSCMGLIDSESSAFDVHYGGCPTFNPGALLLGVHYNWQEVFPVKKEIITHKERI
The following text describes a protein:
Function:
Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.
Subcellular Localization:
Nucleus.
Sequence:
MDDDQQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTGGGVAPKPESSGHHRGGKLSGAYTLEQTKRARLATGGAMDTSGDVSGSREGSSSPSRRRRKVRRRSMENDAHDNSNSSVLQAAASNQSILQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPLTSTNVTKKTESAKLTSSTAAPASGASASAAVQQAHLHQQQAQTTSDAINTENVQAQSQGGAQGVQGDDEDIDEGSAVGGPNSATGPNPASASASAVHAGVVVKQLASVVDKSSSNHKHKIKDNSVSSVGSEMVIEPKAEYDDDAHDENVEDLTLDEEDMTMEELDQTAGTSQGGEGSSQTYATWQHDRSQDELGLMAQDAQQRDPQDGYWTILETVPYSIASAAPNQTLTTATTLSNGGSSLLTGATVVVELPPDDLGNPVGNIQYTIPALTKNATTNTNTTSLLHKPQATTIQIVKQQHQQQHQQQHQHPQQQHQPQQQQHRQHLTIQQSQTHARQEYIKIDTSRLEDKMLLRDVMQYGATSIAMAPQSATTTVVSTHPVESGLLLADADEAERELELEAMKVDQHDEEHLLDDEGYVIEKIHGDGETVNQPQEKLYINGMSNIIHTATTMTLQPDDCKYACNVCGKTYKIKGSLKRHKNYECGVEPNLKCPHCPHKCKCVLAQVVNFVRHGPKNQLLCQCGRYYNTLSRLMLHQREECQDFKRFQCDFCLKWFKRRSHLNRHKKLHDAELFLEPLSKQKPKTTSGQNLSHDANTDDEVATTNPAATEDESNYPFTSEIKIENEFDEFI
The following text describes a protein:
Function:
Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (By similarity). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (By similarity). Phosphorylates and activates NEK11 in G1/S-arrested cells. Involved in the regulation of centrosome disjunction (By similarity).
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore. Chromosome, centromere. Note=STK3/MST2 and SAV1 are required for its targeting to the centrosome. Colocalizes with SGO1 and MAD1L1 at the kinetochore. Not associated with kinetochore in the interphase but becomes associated with it upon the breakdown of the nuclear envelope. Has a nucleolar targeting/ retention activity via a coiled-coil domain at the C-terminal end (By similarity).
Domain:
The leucine-zipper domain is required for its dimerization and activation.
Sequence:
MPSRVEDYEVLHSIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEVEKQMLVSEVNLLRELKHPNIVSYYDRIIDRTNTTLYIVMEYCEGGDLASVISKGTKDRQYLEEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDSKHNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMSCLSYNEKSDIWSLGCLLYELCALMPPFTAFNQKELAGKIREGRFRRIPYRYSDGLNDLITRMLNLKDYHRPSVEEILESPLIADLVAEEQRRNLERRGRRSGEPSKLPDSSPVLSELKLKERQLQDREQALRAREDILEQKERELCIRERLAEDKLARAESLMKNYSLLKEHRLLCLAGGPELDLPSSAMKKKVHFHGESKENTARSENSESYLAKSKCRDLKKRLHAAQLRAQALADIEKNYQLKSRQILGMR
The following text describes a protein:
Function:
UDP-glucosyltransferase catalyzing in planta synthesis of cyanogenic glucosides. Able to glucosylate acetone cyanohydrin and 2-hydroxy-2-methylbutyronitrile, forming linamarin and lotaustralin. Also accepts, to some extent, a wide range of potential acceptor substrates, including simple alcohols, flavonoids, isoflavonoids and other hydroxynitriles such as p-hydroxymandelonitrile, mandelonitrile, (E)-4-hydroxy-2-methylbut-2-enenitrile and (E)- 2-(hydroxymethyl)but-2-enenitrile.
Sequence:
MGSFAIARDERPHAVCVPYPAQGHVNPMLKLAKILHSNGFHITFVNSEYNHRRLLRSRGPDSLDGLPDFHFDSIPDGLPPSDANATQDIPSLCDSTSKHCLLPFRHLLSRLNSSNTVPPVTCVISDACMSFTLDAAHEFGIPDVLFWTPSSCGVLAYAHYRHLIERGLTPLKDESYLTNGYLDTTIDWIPGMKNIRLRDLPSFFRTTERNDIMINFIAREVDRTSRASAIILNTFEAFEKHVLDVLFTMLPPIYTIGPLQLLLDQIPDSKLRNIGSNLWKEQPECIDWLDSKEPNSVVYVNFGSITVVTPQQMVEFAWGLANSKKPFLWIIRPDLVVGEAAMLPPEFVSETKDRGKLASWSPQEQILKHPAVGGFLSHMGWNSTLESICGGVPVVCWPFFAEQQTNCWFACNEWGIGMEIDNDVKREEVEKLVRELMDGKKGKEMKRQAMEWKIKAEESTTPGGSSHRNLVELLRFLQRK
The following text describes a protein:
Function:
Required for transport in the endocytic pathway and for correct sorting of the vacuolar hydrolases suggesting a possible intersection of the endocytic with the vacuolar sorting pathway. May be involved in recruiting the MON1-CCZ1 complex to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns[3]P) or other charged lipids, leading to recruitment of YPT7.
Miscellaneous:
MISCELLANEOUS: Present with 830 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MDKHTAAIPTLTIKVVLLGESAVGKSSIVLRFVSDDFKESKEPTIGAAFLTKRITRDGKVIKFEIWDTAGQERFAPLAPMYYRNAQAALVVFDVTNEGSFYKAQNWVEELHEKVGHDIVIALVGNKMDLLNNDDENENRAMKAPAVQNLCERENLLYFEASAKTGENIYQIFQTLGEKVPCPEQNTRQSSTHDRTITDNQRIDLESTTVESTRETGGCNC
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MTDECNISAGGNTLWLTFLAAWTEEAQAKGSKVARTYRKAHQSLAACPIEFQHPCQTTQLAGIGPTIANKLEQELQRWCQDNGRTMPERPSRQAPSSKQVSAAAQTVSAALDPIAAEQGPSTVAKRNQAGTSERPTKKRAYVPQHRSGAYGLLVGLYVSTRASSALREEKISKTQLINAARPYSDTEYEVAGSSSSSRSSAAIPLSSQYGTSGGAGGARSFYTGWTSMKTLIAKGYVVQSGNPARYALSDEGAAVAETLARDAGVELSVLPVAADYTREEDDDWSEDEQEETLKARISTYRPEILKAGSYTIHLVVDNRERHRPGRRQEKEPIATLLLERGVDTETRALEVGDAVWIARRKQRTGFEADEVVLDHIVERKRLDDLTSSILDGRWRDQKFRLSSSGLSKVLYLIEDYDVENQMRKFGPQIQTALSSSQVVDGFFVERTSGLGASIDYLASMDGMIRKMYEQQDLSVMPSAIISRSSFLDTREELQRKSPTALILTSFEAFQALNSKSGGLTSKEIFGKMLLCIKGMSAEKVREVLTMYSTLRELTDAYQEIAAADVKEAETMLSTFTEGMDQRKKIGPALSRKVAEVLLTPRYAAE
The following text describes a protein:
Function:
Catalyzes the phosphorylation of L-fuculose.
Sequence:
MAIALIFDCGATNLRTIAINEKGQILASHHLANNTKQGIESSDYHIWDIEEIWQKLTSCATQTLNQLMQQGIDLKDIVGISVTTFGVDGAPFDENDQQLYPIISWKCPRTIPVMENLSNQLDIKSLYQRNGIGQYSFNTLFKLHWLKTHKPDVFQKMAKFVFISSMLTQRLTGQFTTDHTMAGTSMMTNLTSGNWDPSILASLGLSNNHFPPMRYAGEKVGKLRTPLAQKWGLNPVPVISCGHDTQFAVFGSGAGLNQPVLSSGTWEILMARTQHAEPRFEFVSQGLTTEFDAQSNCFNPAVQWVGSGVIEWLGKLLFSDVYGSDHYYTTMIKEGEKAFNAGKRAVNFEGIFSQLGQGNISGLSMFATRGEIYVSALQHMANKLKNGLSVLHQVSQFQAKSLICVGGGSKNVLWNQIRANTLNLPIDVVDISESTVLGAAMFTFAGVGIYENVNAAQQAMQPTRKRIYPN
The following text describes a protein:
Function:
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
Subcellular Localization:
Nucleus.
Sequence:
MADSNINKELKQELAYCEEESEKEGQKEAQDSREAQSQTPEKSEVQDSEAKFTPPRTPLSNVEELHTLQERDKVSPDQVLKTPVSDSLKCPETPAQPDSRSKVPHCESPFTPKGRLSQSVISSTGKLPSKGSKHLRLTPLPFTDEMTSSALVNINPFTPESYRKQFLQSSGKRKTRGDLEEASPEEGKVEQGLPAKRCVLRETNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSTKSFIGLSNENLALHEVYAHAVLGHHPHVVRYYSAWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFQEPKLKDILLQISLGLKYIHSSGMVHLDIKPSNIFICHKMQSDSPVVPEEIENEADWFLSANVMYKIGDLGHVTSISKPKVEEGDSRFLANEILQEDYQHLPKADIFALGLTIAVAAGAESLPTNGAAWHHIRQGNLPDVPQELSEEFCGLLKHKGEAEFLKIHQQMLGWSWLGWGDFPNTEASNSSLLVLQHQNMIHPDPGERPSAAALARSRVLRPSLGKAEELRQQLNLEKFKTATLERELREAQQAQSPQEGPGDPGVSGTPTGSRSTKRLVGRKNAKSSSFTCGTSSP
The following text describes a protein:
Function:
Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle. Early endosome membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Sequence:
MGSVSFFLKYQILSTGKGNLAKMTHLQAGLSPETIEKARLELNENPDILHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQTDAFRLLAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLEKRDHYGRKILLLFAANWDQSRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWARTLLGPDYSDENDYTHTSYNAMHVKHTSSNLERECSPKPMKRSQSVVEAGTLKHEEKGENENTQPLLALD
The following text describes a protein:
Function:
Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus, nucleolus.
Sequence:
MSSSVEQKKGPTRQRKCGFCKSNRDKECGQLLISENQKVAAHHKCMLFSSALVSSHSDNESLGGFSIEDVQKEIKRGTKLMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKAQIREKPSQGIYMVYCRKHKKTAHNSEADLEESFNEHELEPSSPKSKKKSRKGRPRKTNFKGLSEDTRSTSSHGTDEMESSSYRDRSPHRSSPSDTRPKCGFCHVGEEENEARGKLHIFNAKKAAAHYKCMLFSSGTVQLTTTSRAEFGDFDIKTVLQEIKRGKRMKCTLCSQPGATIGCEIKACVKTYHYHCGVQDKAKYIENMSRGIYKNVIAVPFSTLILQTKSEALHNWKDLQLEYPTGYWGALGRRKKKRLGSLSAQVPIFKKKEKVKLPCHFEKSFIFSLFTDKLLLIIPKLEN
The following text describes a protein:
Function:
Involved in an early step of the mitochondrial complex IV assembly process.
Sequence:
MADQPQAADETPSKYGRKACAGLRQELIDCLLASDCVQKANLSAIRKGRKKCKATWMDKRGEKKKKKTPTQCSNDNCVAAPKSNFTGSNSTEKGIDDAIKSNRMLMADLQWIKAKGKAIKSRFWPSLLANFAFWTTTANGRGWPTLASCWILEIACMILTDRRKEDGRASLALAWPRHGVAETQQSVYPLVWSWIESIAAFASPANGGHGDELQSCILYSIPFLLAMELDRLDCSLCVSCKRQSCAKWCRACFATSNCTVAMCSITTIASNVDLRKVMSGHWAPLPRA
The following text describes a protein:
Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MERRAEAPPPPQGLDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWLLLNMDKVPEIQYSAPAPCTSRSPATGTTSLPDQYESLKSQLFTHITRFAGGSKIVLTRLCVALASLALSMMPEAWPCAVADMVRMFQAEDSNVDGRARCLALLELLTVLPEEFQTSRLPQYRKGQVRSVLAQECGSVFPLLEQLLQQQDSPGFIKQKVLKCFSSWVQLEIPLMDCENLIQAAFTSLQDPELFDTAVEAVVNAISQPDAQRYVNTLLKLIPPVLGLQEQLRQAVQSGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEPDKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSSLYDKLGRLLTNTEQPSTWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINNVLPLVLQALGNPELSISSVSTLKKICRECKYDLPPYAANIVAVSQEVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLITPYIQQLEKLADETPNPSNKLAIIHILGLLSNLFTTLDISHHDDDHESTEVKKLPVQQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVESVCAIFEKSVKTLLDDFAPMVPQLCEMLGQMYSTIPQASAIDLTRQLVHIFAHEPAHFPPIKALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCSNLDVKALFHCGVLSLKFPEAPTVKASCGFFTELLPRCGEIAPVGQVVHENGKVLLQAVLEGVGGQASRSLMDHFAEILFALNKHCFSYLSIWIKEAMQQDGFPSARVSPEQKETFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTEYTADY
The following text describes a protein:
Function:
May play a role in regulating the intracellular level of maltotriose. Cleaves glucose from the reducing end of maltotriose and longer maltodextrins with a chain length of up to 7 glucose units.
Subcellular Localization:
Cytoplasm.
Sequence:
MLNAWHLPVPPFVKQSKDQLLITLWLTGEDPPQRIMLRTEHDNEEMSVPMHKQRSQPQPGVTAWRAAIDLSSGQPRRRYSFKLLWHDRQRWFTPQGFSRMPPARLEQFAVDVPDIGPQWAADQIFYQIFPDRFARSLPREAEQDHVYYHHAAGQEIILRDWDEPVTAQAGGSTFYGGDLDGISEKLPYLKKLGVTALYLNPVFKAPSVHKYDTEDYRHVDPQFGGDGALLRLRHNTQQLGMRLVLDGVFNHSGDSHAWFDRHNRGTGGACHNPESPWRDWYSFSDDGTALDWLGYASLPKLDYQSESLVNEIYRGEDSIVRHWLKAPWNMDGWRLDVVHMLGEAGGARNNMQHVAGITEAAKETQPEAYIVGEHFGDARQWLQADVEDAAMNYRGFTFPLWGFLANTDISYDPQQIDAQTCMAWMDNYRAGLSHQQQLRMFNQLDSHDTARFKTLLGRDIARLPLAVVWLFTWPGVPCIYYGDEVGLDGKNDPFCRKPFPWQVEKQDTALFALYQRMIALRKKSQALRHGGCQVLYAEDNVVVFVRVLNQQRVLVAINRGEACEVVLPASPFLNAVQWQCKEGHGQLTDGILALPAISATVWMN
The following text describes a protein:
Function:
Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin.
Subcellular Localization:
Cytoplasm.
Sequence:
MIIACPHCDTLNRVPNERLTEQPTCGKCKQSLFAAAPIELTSANFINHAHKSELPIVVDFWASWCGPCKSFAPIFSDAAKAWEPRFRFGKINTEEQQSLAAQFNIRSIPTLMIFKQGHIIAQQSGALPRTALDQWLKGYR
The following text describes a protein:
Function:
Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MKNHLNNNEDNSTLIKKKVLFVIAHPDDECMFFTPTIQHYNFIGSEIFVACLSNGNAVGLGKIREKELIDSCIDMGINQENVFFDQTNNFQDGMNIIWDTDLVEKTILSFIKQTSADIVISFDECGISSHPNHISISNGLKQLMKNKSSSTTTTSTTSSSSSSSSLSNRTTNNLNKEIKAYKLETVNIIRKYIGIADIPLTKLLSYDENSTQTFISTQLFPPSSYSPMTKHKSQFVWFRYLFVFLSRYSFINTLIEIK
The following text describes a protein:
Function:
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Involved in DNA damage response in somatic cells: binds to acetylated histones and promotes degradation of histones following DNA double-strand breaks.
Miscellaneous:
MISCELLANEOUS: Present with 2600 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Domain:
The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones; The YYX motif is required for the association with the proteasome.
Sequence:
MTANNDDDIKSPIPITNKTLSQLKRFERSPGRPSSSQGEIKRKKSRLYAADGRPHSPLRARSATPTLQDQKLFNGMDSTSLLNERLQHYTLDYVSDRAQHMKNIYDPSSRWFSRSVRPEFPIEEFLPYKTESHEDQAKYLCHVLVNLYIAISSLDIQGLISISSKDLADLKKEVDDLALKTDLFRLSNNTAENDLLGNDIADYDDAEGLEDELDEYFDLAGPDFNATGKITAKSATIVNVNHWTNELKNCLHFDFPVALRKSLATVYYYLSLVQGQKVYRQMHVDMFERLVSLDDDRTNFTELLQKQGLLLDHQIMLNFLCEFLPYPDPDYARYELSSKEDLQLFRLLLKHAHNAKPFFDKSKESLLVDTMNFLLSSLAPSTMMAVMPIVTSVVPYHYHIHSKIIDYFPFCYSIWSSVSANVAIDTHMYDFVGSISKDVHNKILSSEHEKDVVGVEFGEFGIFTDDQMTFMFNRLQGHLRTDGQIHSYSRTVKPFVYAINGSKKDRFFEKLVSLAKAIETFIHPSNNGFWTKPNAKFVHAFIKSYHGRVKYEEDICARGVTNGICLTSFCHEEIVEIFLNIISLGSQNKNPDIANYYISCFAYLLELDPSNAYLIYDKILIDLYDTLADQFINSRHRIISSLKQFTRVIRFIVMDKLYRVHITNVLSMLVSKLDMNDTNLTSNLINGIVSIAAFIPIQDLTGEDDYISFESDTLPLVQQHFYHIKCGESSKTFRVDDELLNNAFKASTTVFQSMLKVYVEKIFQLVDVDLEDSLVTKINQTTMILQESMDDKIFNYFASLLQRNFWSNDSFKEKDPNYELVTIPLAALVRRNNGLSKELVRTLLFHIKEQIKRGAGSVRSTSEIQQRDVKLVLYLTALNDVLRQCHESLLEYSDELITFMKYLYDNVTNPPLDVITSIVIHSALATLCTTEITDCRLFPEDSKIPEKDRWGGLQFDPRRFDKQHLSFQWHVPSSDEITLSISILESLSEYCINNVEELMKAPRHDSEYGDMIQKYVLVMTHTLSGSSLLFDPDFNKYRTQSNLSYREKLILLKNIRENNCDPQELDIDIEQIRSGKDDEDYIESKDIEAGLNAGVSDVVQLRDEFPDELIVDEEVVSEMPSGVNTPIAGTHGTDNSAMSSDLAFRDLDIYTCNYYFGNTTEEKLQNPQYLQVHRVRARIGHFFHKLYVFLSTNFENNTNMFQILLHGLKVWFTDLGQETVFNEDPNAFIDVDFLENVQSLSHVNEPFTRTNFAIRANSLHQSRVLLHSTNRKASKLENLLLVDIIQLATSLYPDIYKPAQGTLVHCMKQLVGSYGVVINKIIPSLEKAIKDHDYMKIQVILNVLLIKKIHRKLMTDYKDIGRLIFLLIECCRVNELEIGMYADKILTDIVIGIKIPSSVCVISDQAFLPLAPPDGTINLQVEAVKLAKKKKREYYLSLLVDLQDKLLDKLDNEKDMGWKIRMFILRFVTQIQSNLESKPDKRAVFSIISQISTKHPEIIHLVVKSLLSTCNKIISLSDYEYDITRAYKNEFNPSFVEILDTSTTSFPKTFTEEMNNFDNPKYFIDLRAYVGWLCWGRLMYVMSPKALKLNLRENELEVLKTAGHLLTREFLRDVTMNLVQDNETRGVFSSGNVSFFSLVILLISSGFCELNMSDLFELCESYYNKDDKASMIMSVEIVAGLVCGSKFMSVSDLDKRDTFIENFLAKCLDYELNHDAFEIWSTLAWWLPAVVDLRRSKTFFCHFINADGMFDRESDAATHQTSKIYMLRSILMSMEFRAPDVGKLFDELVFDHPYDQVRQAVAKLLTTLVQNQSNPSISDPTTLLEAERNDPDGLGLPLKSVPEKVDAYIKKQFEIIKNLEDSVVGLNPQQFIKTDYFYRTSTIFYWIKEMARGPNKVLLVPYLVDYVLPFLIGLVKHKDVCALASLDPVRLYAGLGYMPIRKNHVAAIVDYVCSSNVALSSNQTKLQLAFIQHFLSAELLQLTEEEKNKILEFVVSNLYNEQFVEVRVRAASILSDIVHNWKEEQPLLSLIERFAKGLDVNKYTSKERQKLSKTDIKIHGNVLGLGAIISAFPYVFPLPPWIPKQLSNLSSWARTSGMTGQAAKNTISEFKKVRADTWKFDRASFNTEELEDLEGVLWRSYYA
The following text describes a protein:
Function:
Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.
Miscellaneous:
MISCELLANEOUS: Different forms varying in molecular weight have been observed. Such forms are possibly due to different levels of glycosylation and protein cleavage.
Subcellular Localization:
Secreted.
Sequence:
MGWKILPVCLSLLLPVVLIQQVSSQDLSSCAGRCGEGYSRDATCNCDYNCQHYMECCPDFKRVCSPELSCKGRCFESFARGRECDCDSQCKQYGKCCADYDSFCEEVHNSTSPSSKTAPTPAGASDTIKSTTKRSPKSPTTRTIKVVESEELTEEHSDSENQESSSSSSSSSSTIRKIKSSKNSANRELQKNPNVKDNKKNTPKKKPNPEPPAVDEAGSGLDNGEFKLTPPPPDPPTTPHSKVATSPKTTAAKPVTPKPSLAPNSETSKEASLASNKETTVETKETTATNKQSSASKKKTTSVKETRSAEKTSDKDVEPTSTTPKNSAPTTTKKPVTTTKESKFLPLPQEPEPTTAKEPPPTTKKPEPTTRKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPPPTTKKPEPTTPKEPGPTTPKEPEPTTTKEPEPTTTKEPESTTRKEPEPTTPKEPEPTTPKEPEPTTLKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKKPEPTTPKEPVPTTPKEPEPTTPKEPEPTTPKEPEPTTRKEPEPTTPKEPEPTTPKEPEPTTPKKPEPTTTSPKTTTLKATTLAPKVTAPAEEIQNKPEETTPASEDSDDSKTTLKPQKPTKAPKPTKKPTKAPKKPTSTKKPKTPKTRKPKTTPSPLKTTSATPELNTTPLEVMLPTTTIPKQTPNPETAEVNPDHEDADGGEGEKPLIPGPPVLFPTAIPGTDLLAGRLNQGININPMLSDETNLCNGKPVDGLTTLRNGTLVAFRGHYFWMLNPFRPPSPPRRITEVWGIPSPIDTVFTRCNCEGKTFFFKDSQYWRFTNDVVDPGYPKQIVKGFGGLTGKIVAALSIAKYKDRPESVYFFKRGGNIQQYTYKQEPMKKCTGRRPAINYSVYGEAAQVRRRRFERAVGPFQTHTFRIHYSVPMRVSYQDKGFLHNEVKVSTMWRGFPNVVTSAITLPNIRKPDGYDYYAFSKDQYYNIDVPTRTARAITTRSGQTLSKIWYNCP
The following text describes a protein:
Function:
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
Sequence:
MLRLDSSDDKQHLVIRSAGGRGKAAEYSFGIEEEYFLADRRSLDVAIQTPNELFESANWSTGGQAMREMLQSQLEVATNVHVDVNDAREELRFLRREVANVAAQYGFVIMACGTHPTAVWRMSQPSPKPRYEEMIEDLRSIGHRNMMCGMHVHVQLPDPEKRMAVMRAMLPHLPLFIALSASSPFWNSHKTGLKGYRLAAYSELPRTGLPELFESRHDYDEYVGALQRSGVIPDESHIWWAMRPSMKHPTLELRAPDTCTFVDDAVAIASLYRCLTRHLYRRPHLSKTVTVVERAIAVENKWRAQRYGTDCIFASKDGPITISELLSRLIDDIVEDADALNCAAEVEHCRTIVERGSSAEFQLRAYRENGNDIAAVSRWIAASTISGRALRSDAPRLRRHSARASFGNDNGIPEFAVSRAVSWRKA
The following text describes a protein:
Function:
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK. Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS. May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MKDCEYQQISPGAAPPPASPGVHRPGPAAPPGPSPGPAPGAPRWSVSGSGSGSGSGSGSLGRRPRRKWEVFPGRNRFYCGGRLMLAGHGGVFALTLLLILSTTILFFIFDCPYLARTLTLAIPIIAAILFFFVMSCLLQTSFTDPGILPRATICEAAALEKQIDNTGSSTYRPPPRTREVMINGQMVKLKYCFTCKMFRPPRTSHCSVCDNCVERFDHHCPWVGNCVGRRNYRFFYAFILSLSFLTAFIFACVVTHLTLLSQGSNFLSALNKTPAGVLELVICFFSIWSILGLSGFHTYLVASNLTTNEDIKGSWSSKRGGEASVNPYSHKSIITNCCAVLCGPLPPSLIDRRGFVQSDTVLPSPIRSDEPACGAKPDASMVGGHP