lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.
Subcellular Localization:
Nucleus. Note=DNA replication foci.
Sequence:
MVVVMLAAEEPLASTPRRDMDCVGKANTNKKLVQARLPFKRLNPEPKECNEPKRTKGPVAPKCSEPSDQENDQDSSSISHHGPALVNGRGPLDCFMSRRKRSPLRSAPEATIDLTEDSNDSAKQQPAPPIAATCPLSEEKTKTSEGTTEPTIPLTEEETEKDEAEDVDALPLLDITQDSDTEEEEEEEEEEEEQQQEAEVSHGNESVLSTGSTSSASVIASSPEPSKSAPTTPASTSRINAANKVKRRSLKSVQEQEEKQRQRDEKERLKQEAKAAKEKKKEEARKMKEEKEREKKEKKEKDEKERREKKERDEKEKADKLKAKEEQRQMKIEAKLEEKRKKEEEKRLKEEKDRIKAEKAEITRFLQKPKTQLAPKTLASACGKFAPFEIKAHMSLAPLTRVQCEDSVLEDLDRYLAQPDSTLNGLKDWTGHKPRSSGPTRPRHSAQGDCVVITESQKADDGPDRSRYGRMKLLHFHDNYRPAYWGTWSKKSTHISPRCPLRLDKDLLDYEVDSDEEWEEEEPGESLSHSEGDDDDEAGEDDDDDDGFFVPHGYLSEGEGALEDEEGGDPEKQKVRQRMKAREWENELMSKGKVKVLEAVVRGCFWEGEKPLPDFLQPYAVCMLEPLSKDEASTPEQDASRQQRNEKLLTMLLPLLHGNVNSNKVIITEFLEFCRQQTSSPTESLLNTTESIPPRIHVRRIIKENAVYEKRSTFKRCCWYVHADVLARYSQEALPVPCQWSYLTSGANVTRDEHSGSQGNSPTTNSSTTPSNKRKSASSHSITKYMKKCGESEQTEAMETDGFQADTEDDEDDDCIIIGEQSGSSEQDINTSLPQTDRETEPMDTSASETAALALPCPTPATA
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLKKIGIVLLLVHLFQVNGQYSDNNKEFEGSGETTVDTIITDDEDMIDMMEGSTSGMNEVTTTIVRDTPPSLEKETWDEEPEVILESTPPLSGHKDKEEIGEVPVKSKFDVEPSEMGDGDNVEVKDNEDGEVLSEKPSDPKKTVSFAQSSQLMAALIIGGCVGLLFAVCVIMLLAYRMRKKDEGSYALDEQKKPASPSAYQYSQGQEYYA
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MFITRNYTEESGFCEASCSFCSIAKPNPCSSSSKPTIWRWFDVLAIPFDHADKLRPLLLPLHSQDKGRKNRRGVFEAMTMGSSPAATVLVLVMCCLLCGGGAAVEGGLIVELVTPSVSLGSDAQKLQVSVTSSDGSPAPAATVALASVHSVASDSPVSISEQSFASIGDGKYELGLSSSDLFLGKYKLRIDASSDDDKGFLDTVIAVTAPISVSNVKVGVVEGDSVLPESDARLEFKQTTTLSATHLQKLKLAFEVSGPSGALFKPQQVMLKLRGESGVEQTFLIKSSTGNSYELTLDFTKLVEKLNHQSGVYTVDLIVGDDVMENSFLWTLASLDLDLPEGPEGASSAPVSKFGPKPEISHIFRQPEKRPPTYLSMAFLVLTLLPLVGFFVALLQLGVNLKNLPSGGLPLAAAAGFHGGIASILVLYLMFWLKLNLFTTLQVLGFLGLLTLVPGFNILSYLANLSSASKVKTS
The following text describes a protein:
Function:
Activates the expression of pucFG, pucH, pucI, pucJKLM and guaD, while it represses pucABCDE and its own expression.
Sequence:
MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLHKNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAFPIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVSDILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLPIYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFNNFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFLEGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSFGISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKFYNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLGKSLKDPETTMRLRLALRMQRLIS
The following text describes a protein:
Function:
Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MSGSGNKDSPLRVCIVGGGCSGILSARQMLDEGFESVIYELSSCLGGIWAYSDDSEEGRPSVMRSTVLHTSKEMGAFSDFPPPKEAPNYMHHSKMLAYLRSYADHFGITGKVRLRHEVLRVTQADDYNSTGRWDVVVKDLANGIERRETFDAVLVASGRHGFPNAPTFKGQEKFKGRVVHTHSLKVPDQFKDKRVAVVGIGNSAVDAAIDACHVAAEVSLICQRPNILQNAHTSTESGVRVVPYHTEG
The following text describes a protein:
Function:
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Sequence:
MGTYPELPSYVLETGEDLQDVIDKYPDELLGKTVARKFNHTKLPYLPKVLSIAKALPLQLHPNKDLASKLHQKNPDQFTDPNHKPEIALALGDFEAFCGFKPLKDIERTLQLPPLQAFLPQVKKAEFDDQTLKHVVKSMLEASDDVVRKTNDALMALPKEKFGEDSYIPEMIPRLAEQYDKADNGTLVALITMNYLQLKEGESIYIPADGIHAYLSGDIIECMARSNNVLNTGFCPRADRDSVEMFTSCLTFTPHDVKDCMLPSQSFGKSSNGKSKLYAPPLSEFSMYATTLAAGESDTINKIGGPSVMIVTEGEGTLKAEGKEHKLSAGYIFFVGQGVELEFSATKTLKAFTAFAE
The following text describes a protein:
Function:
Involved in the regulation of shoot gravitropism, and tassel and ear development through the regulation of polar auxin transport (PAT) and auxin signaling. Acts as a negative regulator of basipetal PAT, but positive regulator of lateral auxin transport. Involved in the regulation of shoot gravitropism and leaf angle through the regulation of cell development.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Nucleus.
Sequence:
MKLLGWMHRKLRQNSNDVFKEFNNAAGGTCNCITGLAASDPATFLATANEYFTADNDFTNNHPSSPAADLFTFGGSGLLTIGTLGIAAVAVSADADEVDYDVDADADSDFDDNDDTAGDDEDQVDSAVTPTFTYAAPPPIEDATVVEKAAVAVVEAIAEKDDDTTTEDDLMVVSAELEKVLGGRNSGTAGDLVASARVSFAMGVDCPLQGFLFGSPVSDAESRLEQPRDSNGGRRTSLGELFMRTRFAEEKVALVAVEEGEDGGDIGAGGERDDRKAGKGGGGHKTTKKRSAKDEKVPRGDGAQASATVTKSKFHKILQIFHRKVYPESAALARNLTKKSRKRGSGAYHKPEPAASKLRCLKEQRAPGFGCCASRASFGGAASPIDGDDDDELNGSKSGHWIKTDAEYLVLEL
The following text describes a protein:
Function:
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
Subcellular Localization:
Cytoplasm.
Sequence:
MNVLISNDDGYLSEGIAVLARVTAEFANVRVVAPERDRSGVSNSLTLERPLQLKQAQNGFYYVNGTPTDCIHIGQSVFSDFQADFVFSGINRGANMGDDTLYSGTVAAATEAYLMGIPAVAFSLNDASGRYWATAEQALWTLLAHFFKNPPQSPILWNINIPAVAPEDVRGIKIARLGRRHHGQNVIPARNPRGEQIYWIGPVGEVSDREEGTDFGECGAGFITVTPLQIDLTAYPDMAETAAFWHAD
The following text describes a protein:
Function:
Plays a role in the regulation of neuronal activity.
Subcellular Localization:
Nucleus membrane; Multi-pass membrane protein. Rough endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKRRNADCSKLRRPLKRNRITEGIYGSTFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVFFVCVAFTSNIICLLFIPIQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKNFHVDLCRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQQMLQKQEKEAEEAAKGLPDMDSSILIHHNGGIPANKKLSTTLPEIEYREKGKEKDKDAKKHNLGINNNNILQPVDSKIQEIEYMENHINSKRLNNDLVGSTENLLKEDSCTASSKNYKNASGVVNSSPRSHSATNGSIPSSSSKNEKKQKCSSKSPSTHKDLMENCIPNNQLSKPDALVSSCGIKTKRRVCVLFMQISLSDRLEQDIKKLKADLQASRQVEQELRSQISSLSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQKDKQNISQLEKKLKAEQEARSFVEKQLMEEKKRKKLEEATAARAVAFAAASRGECTETLRNRIRELEAEGKKLTMDMKVKEDQIRELELKVQELRKYKENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAEVMAVMPSITYSAAASPLSPVSPHYSSKFVETSPSGLDPNASVYQPLKK
The following text describes a protein:
Function:
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MEFDTIAAISTALGEGAIAIVRVSGDDAVEKVDRIFKGKDLTEVPSHTIHYGHIVDLDTNQVIEEVMVSIMRAPRTFTRENIVEINCHGGLVSVNKVLQLILAQGVRLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAINQMEGRLSKLIGLLRQEILETLAHVEVNIDYPEYDDVEEMTHNILIEKATHVRSEIEKILETSKQGKILREGIATAIIGRPNVGKSSLLNSLVQEKKAIVTDIAGTTRDVIEEYVNVRGVPLKLIDTAGIRETEDVVERIGVERSKEMMSQADLVLVVVNYSEALTNEDEDLFRAVQGKDFIVIVNKTDLPQAIDMERVTELAAGNRVITTSLIEEQGIDELEKAIADLFFEGTIDSADMTYVSNARHIGLLTQAGKTIGDAVEAIENGVPIDMVQIDLTRTWEILGEITGDTVHESLIDQLFSQFCLGK
The following text describes a protein:
Function:
Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.
Subcellular Localization:
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MPNKMLIDATHPEETRVVVVRGNRVEEFDFETAQRKQLRGNIYLAKVTRVEPSLQAAFVEYGGNRHGFLAFSEIHPDYYQIPVADRQALIEAEEQAHREAEEESENRSHGRRRSRHRNARRRGHGERVRSDIVEGLDASADPAAQPVEGQILPEHAEGAPQEGEHLHADAEHHGEHDAHDHHEHDHHDHDHHEHAHDDHHPDHAHDHDDHGHDGGHDHHDHDHADETPAPVAAFGAEPVVATEAVAEPQEATSEAHAEALAEAVTAAAEPADAVYAAGESTEAPHHDADAAAEDDDDEDDDGEEAEEEVVESVGGDDVMEEVPERTFRPRRQYKIQEVIKRRQVMLVQVVKEERGNKGAALTTYLSLAGRYAVLMPNTARGGGISRKITSAQDRSRLKEVVQDLDVPEGMGIILRTAGAARTKPEIKRDFEYLIRMWETVRDLTLKSQAPTLVYEEGSLIKRSLRDLYNKEIDEISVAGESGYREARDFMKMLMPANVSAVKQYRDGQPLFSRMGVESQLDAMFSPTVQLRSGGYIVINQTEALVSIDVNSGRSTREHHIEDTALKTNLEAAEEVARQLRLRDLAGLIVIDFIDMDEKRNNRAVERKLSDCLRQDRARIQVGRISHFGLLEMSRQRIRASVLESSTDPCPHCGGTGHVRSVSSVALQLLRGLEEILMKGATHNLVVRTRTDVALYVLNHKRGHLRDLENGFKVTLAVIADPSVSGPQAYLIDRGEQVHTLEAAKALLAAQAAASPPPVVEEAYDDEEFDPELESEIESEETEGLTEEQAAGEAAPEQDGQRRKRRRRRRGRGGQRDGELREDSAPTLPEPAMVAGESEEDAESEQDGEEGEEQAARGEQQGGGERRRRRGRRGGRRRRGGGEEGLAGSIGDELGTQSPSEATEAVADFDGFGGEAAPSIAQAEHTAEPQIAPPEPRAEVQAEVPAQPEPAPAVVTAEEEPADEKAARRRSTVREKVSFLSSSPSEPATPVAQASEPVAPPAPAPAPAPEAASETPAAPRRAGWWSRRFGGGE
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSLNRLLLQTATVSKNVTRSAFTARKPDFTNPNWLRVGMAFGSTAVLWTLLFRQHSADVQEYKKRNGLE
The following text describes a protein:
Function:
Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code.
Subcellular Localization:
Postsynaptic density.
Sequence:
MVSKDTGKCILTTSESEVEPAACLALEMKYALDPNRQIKKRNKALQVRFKDICEAQNEQRDTQLSSGQLGEKREAKPVSCRAAYRKYMTVPARRSIPNVTKSTGVQTSPDLKKCYQTFPLDRKKGNLKSLPAADPFKSQNNGFLTDAKEKNEAGPMEEARPCGAGRVHKTTALVFHSNQHMNTVDQPLGVNCTEPCKSPEPLSYGEAALQNSTRPPSEEPDYQLLGRAKQDRGRPNSEEPAPPALRRVFKTEVATVYAPALSARAPEPGLSDSAAASQWSLCPADDERRRATHLNGLQAPSETALACSPPMQCLSPECSEQPSQTHTPPGLGNQPSPTAVAAGEECQRIVPHTEVVDLKAQLQMMENLISSSQETIKVLLGVIQELEKGEAHREGLSYRTGQDTANCDTCRNSACIIYSVELDFKQQEDKLQPVLRKLHPIEETQVIPSPYSQETYSSTPKQKSKTESKKHGRWKLWFL
The following text describes a protein:
Function:
Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1. Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection. Mediates 'Lys-63'-linked polyubiquitination of IFIH1. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3. Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA. Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability.
Subcellular Localization:
Cytoplasm. Cytoplasm, Stress granule. Nucleus.
Domain:
The RING-type zinc finger is important for ISG15 E3 ligase activity and autoISGylation. AutoISGylation negatively regulates ISG15 E3 ligase activity; The C-terminal B30.2/SPRY domain interacts with the first N-terminal CARD domain of RIGI.
Sequence:
MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQARPQLHKNTVLCNVVEQFLQADLAREPPADVWTPPARASAPSPNAQVACDHCLKEAAVKTCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICLVEHKTCSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTPSSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKVILDYNTAHNKVALSECYTVASVAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCGVGICYGSMNRQGPESRLGRNSASWCVEWFNTKISAWHNNVEKTLPSTKATRVGVLLNCDHGFVIFFAVADKVHLMYKFRVDFTEALYPAFWVFSAGATLSICSPK
The following text describes a protein:
Function:
Plays a role in the assembly of the HRD1 complex, a complex involved in the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAEGPEEARGHPPGQDDGGGDHEPVPSLRGPPTTAVPCPRDDPQAEPQAPGRPTAPGLAAAAAADKLEPPRELRKRGEAASGSGAELQEQAGCEAPEAAAPRERPARLSAREYSRQVHEWLWQSYCGYLTWHSGLAAFPAYCSPQPSPQSFPSGGAAVPQAAAPPPPQLGYYNPFYFLSPGAAGPDPRTAAGISTPAPVAGLGPRAPHVQASVRATPVTRVGSAAPSRSPSETGRQAGREYVIPSLAHRFMAEMVDFFILFFIKATIVLSIMHLSGIKDISKFAMHYIIEEIDEDTSMEDLQKMMVVALIYRLLVCFYEIICIWGAGGATPGKFLLGLRVVTCDTSVLIAPSRVLVIPSSNVSITTSTIRALIKNFSIASFFPAFITLLFFQHNRTAYDIVAGTIVVKRNGVR
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MKTHKKKKSLGGLFSHSSSSPNLKSFLTEEVIHEQQQQQQQHNNNNNNNNNHQRQPSTTSTSSYIDSASSSIEETSGYLSKTSSSSSLPSSPLHNQNQNQNGNIQLNSSSGSLNNNEQQQQQQSISQTSSPNTSSPIMGKKKPSRLAQAFKRVKNNGNNKLKKEIEELTNKTGLNQQYTHSNLPFNVVESDIDNGSSGGTTSSTGNIISHSKSPSSSSSSSSSKKHQRKSRFIEPISQSTEDYTDIPRIIKMSVEYLFEKCLLVPGIFRESANAMELQRLSQLFEKGGDIDLSEYTDPHCIGGLLKLYFREKPIPIFPYDLHKRIYSVLNEEDSNIKVKSLLESGLGKGQFLILRYLFELLNAVSINCNVNFMNYQNLAICFAPSLIQSFDLSCYDVIERLIENYHSIFGVVVPVVDNSSNVSSSSLAHPIIGGKSETNVSLNNLTVTILDHGDINNNSNSSNNNNSSSSSSPYKKSPKPSPKSSPKLNNRNSISPKLSSSTSFRKSINLSSNSIMISDEVQQEQQNQQQQQDEQQDEQQDEQQDEQQDEQNSNSTSINTSSSSITRPRKGSTVQYLNRINTCRRPSSWTNNNRIKQQQHHHHHHQQQQQHQQHQQQQSSSSESNSSLTSSPQKRLNSVNGLESYEEGKNVNEIYSSLKEESSKLPKKSSLNRQMTIVNSNNIGNGDEKNSDCTTSDEDEELKISKPIIRSTSVNEILKETNDDNNNNDQINNSNSSNNIPKTTITTTTNNTTTTNNISPIVKSKSQIITSSAKVTPTPTPAPMQTSSFLSTKQTNSPSSSSSPSSTVSSTSSSPSSSLSSSIDNKTMSNVNYNRFQPANRTVSSPNVRNFSVPTTTTTTSIGSNSFVSPRFIGKRTTPSIFSPRKQSICKPKNTTSSLSSSSSNISKSTNSTPTPTPAPILTSTLSVNSTSSSSKLQEKALPTKTTFITQTSSPLLLPQPLTSTSTSTSTSTSTSTSTSTSTSTTIPTPTPTTSSFKSNSFSTSNDNSNNNNNNNNNNNNNNNNNNNNNNNNNNVTSPTIVSSPSSPTSPISPTSSTFIKGHSHSNSLSQTPSSSSSSLGNRLTAPGRQLNHTNSTSSLISKFNQIDTPSGINQGWKGGVVVQKKQDPVKKSLAIFEKE
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Subcellular Localization:
Nucleus.
Sequence:
MMAAMEVDDATDIKLDSLQEEYGFINYYKSLPEKLASTVRFFDRSDYWTVHGSDALFVANEIFKTITAIKYLSSGNKTLEYVVVKRGNFESVIRDLLLVKQYRIEVYKSKSLKTQEWVLSYKASPGNLSQFEDLLFGGSSDESARCGLISIKSSKIADQNVVGIAFCDVAACKFVVCQLVDDDRHGNVESVVVQLRPRECLLCEGFAGSVGGAGDESLQAVLQRNGVTVTERKKSDFESSGIALDMNRLLKFPKSSQNPTFATYSEANLTVALSSLSASIKYLDLLSDASYFNQFHISTFQFGNFVKLDGAASRALNLLPSPQDGPGSHRSMFTLLNRCRTHVGQKLLSSWIHQPLVDPNQIDDRLDILQRLIDNSELRACLHDDLLRRTPDLQMAARKLQSKKAGLMECYKIYKVVEVLPKFVEVLGRCEEEDEDGGMVNKRCAKWRELFVDPMKELISDFGKFKEMVETTLDLEKVDDNEFLVKSDFDESLQSLSEQMLEVEGKMTKEFNKAARDLGLETNKTIKLEATTQLGYFFRITRKEEKCLRGNERSYHTLDTNKGGVRFRSVPLETLNDRYLSLKEEFVEQQKGVVVEIVSVACGYVEPLSSLIELIAQIDVFVSLAVASLDGPSPYVRPNIIREGVRKLKLLGVRHPCLERQDGVAFIPNDVIMSSDDKTFHIVTGPNMGGKSTYIRSAAMVVLMAQMGCFVPCDLCEMTLVDGVATRVGAGDNQLKGVSTFMAEMLETANILKSATKNSLVIVDELGRGTSTYDGFGLAWSIAKHIAAELECFCLFATHFHELTSLADELSCVTNLHVTAVTSEDKLTLLYKVEKGVCDQSFGIHVAEIVQFPKHVVENARKLASEMEQAATSFVGSNKSNDGMELNENGDDEEKFLSKVTLEEAKNFLSKAKELSADCTDDVTLWNKIQDLKKSMVENCCQ
The following text describes a protein:
Function:
Required for deacetylation in the mating-type region and the centromere. Acts upstream of the histone deacetylases to promote transcriptional silencing. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, telomere. Note=Associates with major heterochromatin, centromeres, sub-telomeres, rDNA and the mat locus.
Sequence:
MPAITCVWSDGRSDTWPNVNGHSRTRSVPSLKPLPHQDSKNLLYRQICGRLLAQHVFGGAGSTQPILNQLCKRLSTGNPNNTNASTVVTAPEKNVVSARHVRPNPKSSKDTLEKQPKYSSQIYLTDSFENYYLASLPTNYQLYQRDSNRENGNGKREFWLYGHPSGRPFRSVNDFLHHLYWLISDLTRNESTCCCVLCSGNMTRVRKNLQKENERMFHECKDDTYTWPSSYRLGEVVWIDINNELIPAIIVARNLINYESNQMDAVKLISDTFVEPYQYHCKQLGNSRYYFDMAAADIEPWSRHPLDLQKQEHLVAHSICQTWNLFGIFQPLEGIDMEEPKFHDENYSIPLTVLPTFGGESNSLDDHFYGIFRGAEKLWINDLCVISTSSLPSVLQKTSFMYISDIYVNEDDIVCFQGSLWTQIDKNALDYNDSADNIDEHKDDLKELPRRLQMVSKLSNTYFRCLHDKSVEYVCPFADVLGRWYEPWFVKGDLNYTSEVKERTSSRLSAVGSENWVDDDFYEYLLSEIDMVSAVVM
The following text describes a protein:
Function:
Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.
Subcellular Localization:
Golgi apparatus, trans-Golgi network. Membrane, coated pit. Note=Associated with the trans-Golgi network.
Sequence:
MMISQFFVLSQRGDNIVFRDYRAEVPKGSTETFFRKVKFWKEDGNAEAPPIFNVDGVNYFHVKVVGLYFVATTRVNVSPSLVLELLQRIARVIKDYLGVLNEDSFRKNFVLVYELLDEVIDFGYVQTTSTEVLKSYIFNEPIVVSPARLQPIDPAAIFTQGAKRMPGTAVTKSVVANDPGGRRREEIFVDIIEKISVTFSSSGYILTSEIDGTIQMKSYLSGNPEIRLALNEDLNIGRGGRSVYDYRSSSGSGVILDDCNFHESVRLDSFDSDRTLSLVPPDGEFPVMNYRMTQEFKPPFHVNTLIEEAGRLKAEVIIKIRAEFPSDIIANTITVQMPLPNYTSRASFELEPGAAGQRTDFKESNKMLEWNLKKIVGGGEHTLRAKLTFSQEFHGNITKEAGPVSMTFTIPMYNVSKLQVKYLQIAKKSSSYNPYRWVRYVTQANSYVARI
The following text describes a protein:
Function:
Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MFSLIQTSQTSILILLSTITILLVHKIHGWRTTARRKESIAIVVLGDIARSPRIIRHALSFADQQWYVSIFAYTASKPPKALLQHPNIKLVNLAEFPDRIVSRLPRIFFVLVIGPAKALYLSANLMWALLLKANQSSYIMVQNPPAIPTLPIVQLVRLMIGSKLVIDWHNTAYSILALKFGTERHPMVRLAKWTEATFGKHATLHLFVTQAEKQSLSEMWNLQGIKKVFYDRPTKSFCRLTVSEIHSFFRRSSFNCDSILQEMFIEGSLHNETLLTYEDDEDEKRVKMKKSRPALIVSSTSWTMDEDFSLLIDALSLYAQRTKPSSHPRKLPKVLCLITGKGPLRDEYLRIIERRSREEGWKASGIVCQSVWFDDPDDYRMLLGAADLGISLHQSSSGFDLPMKVVDMFGCRLPVCARNFSSISELVKHGQNGLVFDSATELSEQLEELLRGLNSTDEEEPKTDAYTLRSLQDGIENTVYGPPNLPDDQAQLGSHDPSRSSWSCWEDHWNQHVLQTILQTL
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Sequence:
MKSQFVLRGRKLLRCRVYHGPLNLLEQLLMAGLFATRDTMIAASKNPDSSFLFTLSLFHLCGARQQGNLAKRSSKPKQRMAAGLQVFGQPASTDVARVLTCLFEKNLEFELVRIDTFKRQHKLPEFIKLRDPSGQVTFKHGNKTLVDPRAICRYLCTQFPNEGNRNLYGTGSLERASIEQWLQAEAQNFNPPSSALVFHLAFAPHLDIPQDYAAIAENEKKLQQVLNVYDEILSKNEYLAGDEFTLADLSHLPDSQYIVDSDRGRKLFTSRKNVARWFDQISRREAWEQVVKMQMEHPGAFE
The following text describes a protein:
Function:
Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
Subcellular Localization:
Nucleus. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.
Sequence:
MSLQSQVSGRLAQLRAAGQLLVSLRPWPGRSAGGPRPRGSACGPLVALGEHGYCAWLSAGVGAWGAAGRGAWVRTWAPLAMAAKVDLSTSTDWKEAKSFLKGLSDKQREEHYFCKDFIKLKKIPTWKETAKGLAVKVEDPKYKKDKQLNEKISLYRGDITKLEVDAIVNAANSSLLGGGGVDGCIHRAAGSLLTDECRTLQNCETGKAKITCGYRLPAKYVIHTVGPIAVGQPTASQAAELRSCYLSSLDLLLEHRLRSVAFPCISTGVFGYPNEEAAEVVLASLREWLEQHKDKVDRLIICVFLEKDEGIYRERLPHYFPVA
The following text describes a protein:
Function:
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (By similarity). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).
Miscellaneous:
MISCELLANEOUS: Sigma receptors are classified into two subtypes (Sigma-1 and Sigma-2) based on their different pharmacological profile.
Subcellular Localization:
Nucleus inner membrane. Nucleus outer membrane. Nucleus envelope. Cytoplasmic vesicle. Endoplasmic reticulum membrane. Membrane; Single-pass membrane protein. Lipid droplet. Cell junction. Cell membrane. Cell projection, growth cone. Postsynaptic density membrane. Note=During interphase, detected at the inner and outer nuclear membrane and the endoplasmic reticulum. Detected on cytoplasmic vesicles during mitosis. Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum (By similarity). Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding. In motor neurons it is enriched at cholinergic postsynaptic densities (By similarity).
Domain:
The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
The following text describes a protein:
Function:
Multidrug efflux pump.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTMLDTVQHHSQPQSGVPQNHLADEFVETLRLAVPMMLTQLGQIAMITTDLALIGRLGEDAVAAAALAHTVYFVSFTFGLGLMAAVSPLVAQAFGAGDVRRIRRALRVGLWVALLISLPMMASPLYGEHILIALGQVPQSAALAQRYLNGLAWGIAPALGFIALRGMMSAVNRPQPPLWITVAAIPVNAALVYVLIHGLFGLPELGLFGAGLATTLVNLGTFLAVLAIAAWRKPFSDYRPLAHLWRIDWPLVRQLIALGAPISSSLLLEYGLFSSAALLMGLISTTALAAHQIALQVTAVLFMVPLGIGMAATVRVGHAFGRNDPAAVRRAGLVAAVLGVALVSALTVAIILGRYELGRLFFGGSEASAATVELTATLLLVGATFFIADGLQTIMGGALRGINDTRMTLAFAAIGYWCVAFPVAWVLAFHTGLGAVGVWIGFSIGTFVYAGLLVLRFRMLARRLVG