lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MACESLPMSVSWGLLAAFICLVLLYGYRTMSVLQKLGVRGPTPLPFVGNLLTYRKGQNVAFREWRQNYGRVYGMYEGLAPKLVITDPEIVKQVFVKDFSNFPMRMPLCIPIGLPEETLIFADFSHHKRRRGILSPAFTAGKVKLMVPLVNRCADFLMENLDKLFVEETTFDAKQVFSYLTLDVMASTAFGVEVNSQKDPQHAFVVNARKVDLSVVGGMKPSLIIAAVLSMVVPMDVLEKWGLTVVPADAVSFFHSILETILTMRIKQQPNERRMDLLELMRAAREEHCLDLPEEFEKSLSADEVTTDAISFFLAGYDTIAGLLGTTAVNLARYSDMQDKLLQEVATVTEEQGYVQNEDIQKMEYLDMFLMETLRMDSGARFPRLCTQDTEISPGLTVPAGVEVIIDSDSLHIDPEYWPEPETFIPERFTKEESNKREPFTFIPFGQGPRTCIGMHLALMATKITLVRILQKYRFVAFNVTVEVNELNKAADLRLTDHGLGFFVRNQWVKLERLDY
The following text describes a protein:
Function:
May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MDSRHHPVNQYTTCAEGLEADSIPAHGISEREESATASRPPEAEDLDCYSMMEPPPLDWRSDSSSEAGSPEDLVDSTLPQSACSLGIEDLGESGCQPMDAGRKMTSFDPKTDFFLGNTAGSVQNIEVKLEKELQEEVAAEVVEDQEEMTSRDAEKKVDNDKTHVLSRRPDDEDHNHIHTLLSHLQLREKDSHTSHQSSFQPEPGARTSFRRREDGAESKGLLFSESHHTDLLGLLQCTEINAESRSVYRSHRGEVDAVVSVSYSQEDAQRFWGLHGSSQHPQHRDDSISPLSDYNYPEPVWKKMGEEPPEDEVEAESKQSSDDRPSYKDVPGPCDPEDLLDGVIFGAKYLGSTQIKSDRNPSTNARMAQAHEAVDRIKAPEGESQPMTEVDLFISTQRIKVLTADTQEAMMDHALQMISYIADIGKIVVLMARRKQKGHEGDSASTGSQKKCTMICHVFSSEDAQIIAQAIGQAFGVAYQQFLQASGIKASDLRPGEYSDYLETQELYNGDLAHFSDSQNLRDVVITKAPGEILGLAVVESGWGSILPTVVVANLLHGGPAERCGELSIGDRIMSVNGTSLVGLPITTCQNIIRDLKSQKYVKLSIVHCPPVTMAIIRRPDPKFQLGFSVEDGIICSLMRGGIAERGGIRVGHRIIEINGQSVVATPHEKIIQTLTNAVGEIHLKTMPASTYRLLTGQEQPVFL
The following text describes a protein:
Function:
Involved in organellar RNA editing. Required for the processing of numerous RNA editing sites in mitochondria and plastids. Binds to the plastid RARE1 factor, a pentatricopeptide repeat-containing protein involved in RNA editing.
Subcellular Localization:
Mitochondrion. Plastid, chloroplast. Note=Dual targeting to mitochondria and chloroplasts.
Sequence:
MATHTISRSILCRPAKSLSFLFTRSFASSAPLAKSPASSLLSRSRPLVAAFSSVFRGGLVSVKGLSTQATSSSLNDPNPNWSNRPPKETILLDGCDFEHWLVVVEPPQGEPTRDEIIDSYIKTLAQIVGSEDEARMKIYSVSTRCYYAFGALVSEDLSHKLKELSNVRWVLPDSYLDVRNKDYGGEPFIDGKAVPYDPKYHEEWIRNNARANERNRRNDRPRNNDRSRNFERRRENMAGGPPPQRPPMGGPPPPPHIGGSAPPPPHMGGSAPPPPHMGQNYGPPPPNNMGGPRHPPPYGAPPQNNMGGPRPPQNYGGTPPPNYGGAPPANNMGGAPPPNYGGGPPPQYGAVPPPQYGGAPPQNNNYQQQGSGMQQPQYQNNYPPNRDGSGNPYQG
The following text describes a protein:
Function:
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MVLSPGRVDFWLTIFTELEMRSNPMAGCQHVRLCKLQKRKVASIKRTVMIDKVGSSVTNSQMHVGYIVAERLRAPKNPVILCHDNDWAFVALSYWRLPLNSCSIDTTSIIRLRSSSMEQIARLGMQLFAYQSPRKESVDSVVHVTFCMNMAANYESSCYSLEYRIFHYINLPTVDLKLNDIIGYVKLRIGPQSVPFLQLKYWRGIYDALQDLGCDVHIARVGSVSPIKTRAHQLTSYIDRTTPGKSVNLIAHSMGGLDCRYMVTHISPKSFRIGSITTVATPHCGSSFMDWCRDALGLGKLQRYVQHYADDSIATSILNTTSSTLCDIDNDRSWSPTQSLSSQVSAKKSSSQLSKPRSFKSKQQSDSVSKTIHFLESRDISSDFPSCSYKPVAKSHPIIRAIFSPMDAPAFTNLTRAYCAAFNQATPDDPNIYYASYAAVADVSKLAPLHFSHQIINRLEGANDGLVSLKSAQWGEFMGAVDCDHWDLVPPKVRGLTSAITGKRFDAIGLYLRMATELADRGL
The following text describes a protein:
Function:
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
Subcellular Localization:
Cytoplasm.
Sequence:
MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRTGIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGVNVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDENGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQIARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPRMTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAGDYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGDLLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAAHHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGFSPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCLMTEAPGEVSDAQLDELHLSIKKKVKN
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MSSSRGGGRRGGGAKSAHYSRRNSNQNWVIKSPIEQQGSQLSSSSLNSGEKDEALSVIATVQEPISEFVREDRKPHRNPIYPEGSQLSSSSSLISGENVEVSSVREKVQEPISEFNQKDLKPDQNRRNSKRVPRNSRINGNFEKKSEDEESSREVVDVLSSCVMEEKLSCDKEGKNGAGVEKVEGSGVDDVWRRLEELQLGAEEPELSTEQLRINDQAQEDELLALESIFGDNVFVLDRRNGLRSFQIHVHIEVPDELTVSVNLNSSGALGIPDDSSPEFSYSLKVEHLPPIVLTCLLPKSYPSHLAPLFTISVQWLNSTNISSFCSMLDSIWKEQLGQEVLYQWVEWLHASSLSHLQFDQEIKLGFCAERHIGDRRAISGTVSPEVDIPSLKSYDEEQRHENFRRNIHQCCICFSEFPGMEFVRLPCQHFFCWNCMKTYSDMHVKEGTITKLLCPEAKCGGMIPPGLLKRLLGEVEFERWESLMLQKTLESMKDVCYCPRCETVCIEDEDQHAQCAKCFFSFCTLCKEKRHVGVICMTPEMKLLILQERQSSSQLKDSQRQREKEMINDILSMREIHRSAKQCPSCKMAISRTEGCNKMVCDNCGAYFCYRCNQAIDGYEHFRDGKCELFPPEAIQMWEERINARQVIGQIQAQMLPNRAHPCPNCRQMNVKVGNNNHIFCWACQNHYCYLCGKTVKRSSQHYGPKGCKQHTVDE
The following text describes a protein:
Function:
Specific cargo receptor protein for the plasma membrane ATPase PMA1 that acts with PSG1 to promote the transport and maturation of PMA1. EXP1 and PSG1 probably act sequentially to promote PMA1 sorting between the ER and the Golgi, with EXP1 promoting PMA1 export from the ER to the Golgi while PSG1 has a role in PMA1 maturation or quality control in the Golgi.
Miscellaneous:
MISCELLANEOUS: Present with 3260 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Cycles between the ER and the Golgi apparatus.
Sequence:
MNLYGYFLLLIIVIAFIALLPLFSGIGTFKLTKPKSSATAQSATGKLGKREYLKKKLDHTNVLKFDLKDTEESLGHDSASASSASRKFEIDSKTGLKRRVIGQYNKDPNDFDFDIDDLINEDELDERREEEKKLKKYNGKKNEAYEGFV
The following text describes a protein:
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain.
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MNSSPAMAPSSPVLFSPSLARRPPSPGRRPNTNFRSASPSIMTSPKLWQKAAISRLAEEFFWIGGSIVASPKWRMGQIVERCMCNMQAGSQMIKLRGKSKALVRLFYLDEHKSCIRWRPSRKHERAKITIDSIHEVCEGMRTEVFRRFANNNFDPNCCFSIYHGDHVESLDLVSTNGEEARTWITGLKYLLAGISDEDSLAKRQRTRDQWLRQTFSEADKNGDGNLSIGEVLQLLHKLNVNLPKQKVREMFQEADTDENQGSLTFEEFCTFYKLISTRRDLYLLMISYSNHKEHLDLNDLQRFLESEQKMVNVTKEYCKMIINQFEPCSQNQSHVVLGIDGFTNYMRSPAGDIFNPEHYQVNQDMTQPLTNYYIASSHNTYLTGDQLLSQSRVDMYAYVLQMGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVVETINKYAFAKTQFPVILSIENHCTVPQQKKMAQYLMEVLQDKVDLSNINTNESRRLPSPEDLKGKILVKGKKLPANIDADADEGDVSDEDSGEEDEEEELQLNGDTTEGAPESASADESKKRSRRKFMGSFRRKKKKQVKVKKKPIVSDSDTEPEITSTNDKQVINYGKRRKTMRLSRALSDLVKYTKSVRVHDIETQAYMSSWQVSSLNESITNQILQLKPAQLVRFNQRQLLRVYPSNYRVDSSNFNPQPFWNAGCHLVALNYQTEGRMLQLNRAKFAANGNCGYVLKPKCMCKGAFNPVLEDPLPGHRKSQLVLKIISGQQLPKPKDSMLGDRGEIIDPFVEVEIIGLPIDCNKQQTRVVDDNGFNPTWEETLVFTLHMPQIALVRFMVWDHDPIGRDFIGQRTISFKSMMPGYRHVYLEGMEEASIFVHVAVNDITGKVKSSNAVKQLIQKNLMQTSEDGTRKSFAPNFLRKSGKNQSKVVKVECYTKEDFLNRRYSDDVSSKDSRSTSQSASLLRGAQSEPLKRAHRVSFQEPEGSHEPRRRLSSIPYTGGAAVDYTNLAFDSHSSSELDIQTFSHLEDNTESKQNDSLSSKLEFESTDIPKSPASTLNEQCLSRQISAANEHSEQKPEMSKMIHSVPDPLNFHPIPDGVLDPSRGTLNTLVPQNKFRSSLDARLNPRWQPLSIPATPALNRRMNDKGTPNSLLKGCRSQSVPRRRPTSPPNTPGHIRRDPINQYFLPQCSYTTANDLVPNNHNIAESESSSLSSLDSLDLSTLPCRFPDNQQQTMGTLQREMNALFEQKIQEIRCHSPLFFRDSSTL
The following text describes a protein:
Function:
Catalytic component of the RPD3 histone deacetylase complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. SIN3 also has a RPD3 independent function required for normal longevity.
Miscellaneous:
MISCELLANEOUS: Present with 1660 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSQVWHNSNSQSNDVATSNDATGSNERNEKEPSLQGNKPGFVQQQQRITLPSLSALSTKEEDRRDSNGQQALTSHAAHILGYPPPHSNAMPSIATDSALKQPHEYHPRPKSSSSSPSINASLMNAGPAPLPTVGAASFSLSRFDNPLPIKAPVHTEEPKSYNGLQEEEKATQRPQDCKEVPAGVQPADAPDPSSNHADANDDNNNNENSHDEDADYRPLNVKDALSYLEQVKFQFSSRPDIYNLFLDIMKDFKSQAIDTPGVIERVSTLFRGYPILIQGFNTFLPQGYRIECSSNPDDPIRVTTPMGTTTVNNNISPSGRGTTDAQELGSFPESDGNGVQQPSNVPMVPSSVYQSEQNQDQQQSLPLLATSSGLPSIQQPEMPAHRQIPQSQSLVPQEDAKKNVDVEFSQAISYVNKIKTRFADQPDIYKHFLEILQTYQREQKPINEVYAQVTHLFQNAPDLLEDFKKFLPDSSASANQQVQHAQQHAQQQHEAQMHAQAQAQAQAQAQVEQQKQQQQFLYPASGYYGHPSNRGIPQQNLPPIGSFSPPTNGSTVHEAYQDQQHMQPPHFMPLPSIVQHGPNMVHQGIANENPPLSDLRTSLTEQYAPSSIQHQQQHPQSISPIANTQYGDIPVRPEIDLDPSIVPVVPEPTEPIENNISLNEEVTFFEKAKRYIGNKHLYTEFLKILNLYSQDILDLDDLVEKVDFYLGSNKELFTWFKNFVGYQEKTKCIENIVHEKHRLDLDLCEAFGPSYKRLPKSDTFMPCSGRDDMCWEVLNDEWVGHPVWASEDSGFIAHRKNQYEETLFKIEEERHEYDFYIESNLRTIQCLETIVNKIENMTENEKANFKLPPGLGHTSMTIYKKVIRKVYDKERGFEIIDALHEHPAVTAPVVLKRLKQKDEEWRRAQREWNKVWRELEQKVFFKSLDHLGLTFKQADKKLLTTKQLISEISSIKVDQTNKKIHWLTPKPKSQLDFDFPDKNIFYDILCLADTFITHTTAYSNPDKERLKDLLKYFISLFFSISFEKIEESLYSHKQNVSESSGSDDGSSIASRKRPYQQEMSLLDILHRSRYQKLKRSNDEDGKVPQLSEPPEEEPNTIEEEELIDEEAKNPWLTGNLVEEANSQGIIQNRSIFNLFANTNIYIFFRHWTTIYERLLEIKQMNERVTKEINTRSTVTFAKDLDLLSSQLSEMGLDFVGEDAYKQVLRLSRRLINGDLEHQWFEESLRQAYNNKAFKLYTIDKVTQSLVKHAHTLMTDAKTAEIMALFVKDRNASTTSAKDQIIYRLQVRSHMSNTENMFRIEFDKRTLHVSIQYIALDDLTLKEPKADEDKWKYYVTSYALPHPTEGIPHEKLKIPFLERLIEFGQDIDGTEVDEEFSPEGISVSTLKIKIQPITYQLHIENGSYDVFTRKATNKYPTIANDNTQKGMVSQKKELISKFLDCAVGLRNNLDEAQKLSMQKKWENLKDSIAKTSAGNQGIESETEKGKITKQEQSDNLDSSTASVLPASITTVPQDDNIETTGNTESSDKGAKIQ
The following text describes a protein:
Function:
Component of the SRP (signal recognition particle) receptor (SR) (By similarity). Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit srp54 (By similarity). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Thought to be anchored in the membrane through an interaction with srprb, which contains a bona fide transmembrane domain.
Domain:
The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the signal recognition particle (SRP) complex subunit SRP54 (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). GTPase induced rearrangement of SR drives SRP-mediated cotranslational protein translocation into the ER (By similarity).
Sequence:
MLDSFTILTKGGIVLWSKEFAKIKGSPINSLIKKVLLEERSAETSFQIDSYSLKWTFSNEFDLIFVVVYQKIFTLLYIEELLTTVKKRFIKMYKDLLLKLKESSDFIIVDKFQEFNFEVILEDVENRSKLQQTSNSAPKKYEDTDKGKLVKDQKNERAIKEGRVEKVKRKEQEKKEKAERRKQNKANNINDISSDDDSDDSDSSSGSDSEENSNGATKNQQTDVARIENSGYKKKVKDTPDKQASSSTGKKARTWEDGKLSKKELEALNRSDNSNGTEIVREKIQKFNIDMDVSSSDDDDEEEAKPVSGFMKYFNVLTGNRVIDKQDLEPILADFKLHLTKKNVAPDVADKIVQSIGTGLEGKKLATFQGVTSVVKQQMEDTITRILTPKRNIDILREVQAVKGKRPYSIVFSGVNGVGKSTNLAKVCYWLTANGYKCMLAACDTFRSGAIEQLKTHADRLNVHLFERGYSKDAASVAQDAIAFAKDTGYDVVLIDTTGRMQNNEPLMKALSKLVNQNNVDLVLFVGEALVGNDGVDQLTKFDKSLSLLANTTQTHIRTIDGIILTKFDTIDDKVGAAISMVYSTGHPILFLGTGQNYTDLKRMNIKSVVKSLLH
The following text describes a protein:
Function:
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. May be involved in neuron development; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
Subcellular Localization:
Cytoplasm. Membrane, clathrin-coated pit. Cell junction, focal adhesion. Cell projection, axon. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle.
Sequence:
MEFPFDVDVLFGERITTVDQRLQPSGRRGAGLSAAHRMDLQQQLMTVIDEMGKASAKAQNLPTPITSTSRMQTNRHVLYILKDSEAKTVGKGIIIGFLKVGYKKLFVLDRNGAHNEVEPLCVLDFYIHESLQRHGYGKELFHYMLQRERVEPHQLAIDRPSDKLLSFLRKHYCLSDTIPQVNNFVVFQGFFSYQRAPMRKMPPKRHEGEIKPYSLSDREFLKEEVEPPWPFNQSHSMIRSSSVGNSPVRGCLKPFLNEQELLKNLRLCPPHSTAQHLMNGEPCDSVSQRRRTRYGKACAEPCA
The following text describes a protein:
Function:
Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by egt-3 and other mitochondrial proteins (By similarity). Hydrolyzes ATP (By similarity). Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAPSIKLSTMATSLHRAHGTSALLRRPRLWAPRLSSIHATPTIANLRASFTTSSPRLFAPNGSAKDESKPAVSTVPKTTGRGPSDPLAAIDKTAQEQRKADWAIMKEMSKYLWPKGSWGDKARVLLAIGLLVGGKVLNVQVPFYFREIVDSLNIDFSTTGGSVTAVAGAMILGYGAARVGAVVSQELRNAVFASVAQKAIRKVARNTFEHLLNLDLSFHLSKQTGGLTRAIDRGTKGISFLLTSMVFHIVPTALEISMVCGILTYNFGWQYAALTALTMVSYTAFTILTTAWRTKFRRQANAADNKASTIAVDSLINYEAVKYFNNEAYEVGRYDKALAQYEKNSIKVATSLAFLNSGQNIIFSSALTVMMYMGAHGVATGQLTVGDLVLINQLVFQLSVPLNFLGSVYRELRQSLLDMETLFNLQKVNVTIKEQPNAKPLTLTRGGEIEFKDVTFGYHPESPILRDLSLTIPAGKKVAIVGPSGCGKSTLLRLLFRFYDPQKGAIYIDGQDIRSVTLESLRRAIGVVPQDTPLFNDTVEHNIRYGNLSATPEQVIEAAKAAHIHEKIISWRDGYNTKVGERGLMISGGEKQRLAVSRLILKDPPLLFFDEATSALDTHTEQALMENINAILKGLGQKGEKKTSLFVAHRLRTIYDSDLIIVLKEGRVAEQGTHRELMERNGVYAQLWRAQEMLMTEEGEVSKKGEKEEVGEKKEA
The following text describes a protein:
Function:
Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
MAAPGPASPALPPFRPPTSGPSAPNSNGPPFWGSAAGAAMAPGLRAGLRDAAVQNSNSSSNEGDAIKVFVRVRPPSEGSGLPDGEPGLCLSVLSSKTLRLNSKPEPKIFTFDHVANMDTTQESVFSSVAKSIVESCMNGYNGTIFAYGQTGSGKTFTMMGPAESDNFTHNLRGVIPRSFEYLFFLIDREKEKAGAGKSFLCKCSFIEIYNEQIFDLLDSASTGLFLREHIKKGVFVVGAVEQVLTSAAEAYQVLSRGWRNRRVASTSMNRESSRSHAVFTITVESMEKSNEIVNIRSSQLNLVDLAGSERQKDTHTEGVRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTSIIANVHPGSKCFGETLSTLHFAQRAKLIKNKAVVNEDSQGNVSQLQAEVKKLKEQLATFTSGQTHTKTLSTDEESTDYRSEFLEAMLFFKKFESEKKTLMEKVAQLEDLSIKKEKFIQSNKMIVKFREDHIVRLEKLQKEARGSFLPEEQDELLSELREEIRTLREQMEQHPRVAKYAMENHSLREENKRLRSLQSVKKAQEIDAQTISQLENAFLEIMGSEKNREDQQVYPITSTVDTNSLASAEKLKVQLLQTQSELSSSKQEYEEFKELTKKKQLELESELQSLQKANLNLENILEATKAYKRQEVSQLNKIHAETLKIITTPTKAYQLRSRLVPRLSPEILTLGSMETPNSKDLEADIFSEPIPPEMTEQAYEAITEELSIVQEQLSATQAKLDEEERKNMKLQQHIDKLEHHSAQMQELFSSERTDWNKQQNELLEKVNSSEKQIQDIQSKNDFMKSEVLDLRVVLQSADKELSTVKQEYSTFRENQEKELSQLSERHMNVQLQLDNVRLEHEKVLERKACLQDSYDNLQEVMKFEMDQLSQELQNSKQENLTLKADLNNLLELLETEKERNNKLISQLEEDKENSSKETLKIIQSIQQEKQKEVTKYEQQTEKVQKLEQNLLAAEEMIASLEKTKVADKKVVTDLMNQIQELRTSIGQKTETIDMLKSELEDINCRYNSTLTDKEDYKTMLEKQEEQIVELKETLKRKQLAEDIEREMMCEDLVHVTEQLNKLTEASKNHSVLLQSAQEELAKKEGLIRELQEQLSQNKKELEQRKNEYGLKMRQLECVMDSATGFPQSPKTPPPFQANLAKLLETQEQEIEDRRASTISLQHLVSKLNEERDAKNVDILRMKEQLCELENTRLEVQQLIEKNRALQSELEVIKGQKHGSNQKYPDIRQLIKEREKEIVEERLAKNKATEEMMRLKTELEDAKNVLKSRELIWVTMSEEVERTRALESKAFQEKEKLRSKLEETFEEKDKIAQVSQVFLVSLICDISLI
The following text describes a protein:
Function:
Could be a guanine-nucleotide releasing factor for glo-1. May play a role in gut granule biogenesis. Regulates axon termination in PLM and ALM neurons.
Sequence:
MFFKRSTNSRKTSANSSSDTSTSSESLLLPLLNNTKAGARSQKGSVHRQSGKKARRKMMENPYVCSLELDELSADDSIIDYSVFSDDSFLLILLLTSKGDVQAYLETSRDTKPRKNVVNIKTACSLNVSPVTVCIGSQAAFAIFGLADGNLLVTPIRLLIDVTWGGSSWATTTVIDLSLPTVDPCLATPTCTKCFVSNFPPCTMAVVANKAGNILLVDLHLRKCVSELKAPQSLHQIDILLDENSIELLVTGFTGAQWIIPIERSGKGFREVLTTCVPSDLTVLEPATMQFFAADSCGVVALDTTESIVEVYNTFHSLAHSSKRTFKVPPETWMVHAGDNMLFTVSNDNEIRSALHFGFMSSRLEYTLVRTSTNWRPLGIVAMPSRPHKLAGIFVVNERGLVRVEQSTALNLTKIASEFFFRLSPLQLNSKSVAQVANACRIDTAEFQSALIPNLLSTRKNRQLTNKELSQIYSIAKAINLSMSDLLKAFENESIGEQLLPEVLNTIQTNPAKHDNLMQRVVEMFVKRSLSAEGNMDKIREYDAELSNFLARHEHLHKGSVDCAKAGMWKCTQTLVRRDVHETKSIDTSTEVLLYIIKNRLQIWNEANSTDRLQIMSLVCHLDWSKLADADGARVCAILSAWQRDISLPSYHEMCLRIAITNSDRFPRPCQILSLVSSIHILSEKKISNHANLPNFLPLAGGNNCGATITEDDRLMIWGNFTNAQQRMEMPQMNAKSKRSDSVTNGAPTLPPPAPKPEQHLPRVLEYPGGRPRAIACGAEHILVLSSSGQLSAWGGNRFGQCGVGHSFRIANLHQVDGDWPAIEKIACGQFHSAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLICKVTQIACGRAHTVVLTDTGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPLRVRDIATHYYHSICITEDNRVFEWGRNPQELKMRMFVMKKIRSAQLKNTEDPSSPSPSTNGSTPRVNLNLPAEIPREDLGLREVKHFLDGNIVSVACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERMEPHQVFEPNGAKWVNVSLGNNHTIASTDDGSVFAWGKNDFGQCGVLTKKNGNSADVTKKFFFQARDGRRFMPNVDESQFVQKPGLIPDVRVRNLNEDGNEGVDKEEIVDRLKASDVNVVQAVSKHLYSPIEGKCNGSIIEDEPRNGKIQKQNKYDGEDGPLCTTTALVHLIAGDVKRAIRMIEWLKTDSSTCEKSLMVLSSLVWEVMANHEDVQSREALSAAFRHVPMSDSMRKGKQIAQLWPAVWNDERVQSSLSIDEKIAMLDGFTSASKPVSCPTIPSSSLEVSSKIRVYAQCAHAEPAAVGSPPECSTCLDEWTEKVRHTLGTQL
The following text describes a protein:
Function:
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Nucleus speckle. Note=Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H(2)O(2).
Domain:
The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones.
Sequence:
MEAPERAGGGEPPEPGGRPVLGPRAFVPQKEIVYNKLLPYAERLDAESDLQLAQIKSNLGRAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFARLLINLLKKKELLSRDDLELPWRPLYDLVERILYSKTEHLRLNSFPNSIENVLKTLVKSCRPYFPADSTAEMLEEWRPLMCPFDVTMQKAISYFEIFLPTSLPPELHHKGFKLWFDELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDPYVPKIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRLPNSVVRRLHRERFKKPSWLTPVPESHKLTDEDVTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLALMRPELVIPPVLERTYPALETLTEPHQLTATLNCVIGVARSLVSGSKWFPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIGTFSTLVPLVDCSSVLQERNDLTEIEKELCSATAEFEDFVLQFMDRCFGLIESSTLEQTREETETEKMTHLESLVELGLSSTFSTILTQCSKDIFMVALQKVFNFSVSHIFETRVAGRMVADMCRAAVKCCPEESLKLFVPHCYGVITQLTMNDDVLNEEELDKELLWNLQLLSEITRVDGKKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHHLLRSTTLIYPTEYCSVPGGFNKPPSEYFPVKDWGKPGDLWNLGIQWHVPSSEEVSFAFYLLDSFLQPELIKLQCCGDGELEMSRDDILQSLTIVHSCLIGSGNLLPPLKGEAVTNLVPSMVSLEETKLYTGLEHDLSRENYREVIASVIRKLLSHILDNSEDDTKSLFLIIKIIGDLLHFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRKDVTQQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPALVSSGLSQAMSLEKPSIVRLFDDLAEKIHRQYETIGLDFTIPKSCAAIAELLQQSKNPSISQTLLSPEKIKEGQKRQQDKNADALRNYECLVNTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLKRTHKKLTINPYEISGCPKPTKILAGDRPDNHWLHYDSKNIPRTKKEWESSCFVEKTHWGYYNWPKNMVVYAGVEEQPKLGRSREDMIEAEQIIYDRFSDPKFVEQLITFLSLEDRKGRDKFSPRRFCLFKGIFRNFDDAFLPVLKPHLERLVADSHESTQRCVAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNMTVETYNDWGTCIATSCESRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTAPTTSPCIPEFTARVLEKLKPLTDVDEEIQNHVMEENGIGEEDERTQGIKLLKTILKWLMASAGRSFSTAVKEQLQLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPQQVPLILQVLSQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLIICLLEDEQLEVREMAATTLSGLLQCNFLTMDSAMQIHFEQLCKTKLPKKRKRDPGSVGDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQLLMNLSAHLNDPQPIEMTVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYYA
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Sequence:
MQKYVKFFNIAQQLKFVKRKGWTRFPPIKEVESVADHSWMIQMIALSLPTNELNKDKCIKIALLHDLAEVIVGDIIPSENMPANEKKQKEDNAMRMMVQDLDEDIKNELYSIHKEYENGESIEAEVVRELDKLEMLFQAFDYEQKYNVRLDEFYSCEGRIKTKYVRPLLDELLKQREQFLSQ
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Subcellular Localization:
Nucleus.
Sequence:
MSKQKTLFSFFTKSPPVSSSTKSGKVSSSPTEADVPSSGGKKSSSSPKEGAKEKAAGAAARTPGGKAPKSAAPSTACDFNPGDLVWAKMLGHPWWPSLVYNHPKEGTHLRGKGKSLHVHVQFFDDSPTRGWTGAKYIKPFSGSTAAETQKGGMFFSTKPEIKKAMKMADDAVTLDKQKRLELAVCMEPSDSEEDMEVEENSSASHDEEVKTKTPSRESKRKGQPKRRRIMIESDSDNEGSDDEFKPEDSASSDEASSGVDEAGLSEPDSEAEDNSPVKVPLKRKRGIPDKASGPKKRLQNEQSETPKRTSNVSTEAKLKLSSFSAPESFESQANTGGTGAVSIWEHEKFDWLQDGKRKDMKRKRQTDADYDPSTLYIPDDFLNKCTPGVRKWWQLKSQNFDTVIFYKVGKFYELYHMDAVIGVNELGLTFMKGTWAHSGFPEIAFGRFSDVLVQKGYKVSRVEQTETPEMMEARCKSMSHPSKFDRVVRREICRIITKGTQTYSVLDGNPSESHSKYLLCFKEKMDDSSGQRRVYGVSFVDTSVGKFHVGQFEDDRHCSRFRTLVAHFPPVQILFEKGNPSSDTKKVLKSCLSTSIQESLQPTSQFWDASRTLKTLAEEAYFEKDFQPATGNGNLPSVLKSMTSESDSLALTPGEKCELALSALGACIYYLKKCLIDQELLSMANFEEYVPVDTDVEKAQTSSNFFAKTSRRMVLDGVTLTNLEILQNGTNGSTEGTLLEKLDTCSTPFGKRLLKQWLCAPLCNPFSINDRLNAVEDLMALPGKVSEVSELLKKLPDLERLLSKIHSIGSPLKSQNHPDSRAVMYEEITYSKKKIADFLSTLEGFKVMREVISIMEDDVAHFKSSILKQIVCVKDKASHGRFPDLSAELKRWDTSFDHEKARKTGVITPKAGFDPDYDEALKDVKQAEQDLNEYLDKQRKRLGCKTVVYWGTAKNRYQMEIPENIADRNLPEEYTLKSTKKGFKRYWTKAIEKMFGDLVNAEERRDAALKDCMRRLFYNFDKNYKEWQTAVECFAVLDVLISLSQYSQGGDGPVCRPEIVLQENGSPFLELKGSRHPCITKTFFGDDFIPNDILVGCKEEDSDDGSDEAHCVLVTGPNMGGKSTLLRQAGLQVVMAQLGCYVPADSCRLTPVDRVFTRLGASDRIMAGESTFFVELSETSSILQHATEHSLVLLDELGRGTATFDGTAIAGAVVKELSESIKCRTLFSTHYHSLVEDHSHSQSVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLAHIPDEIIQVGHQKAREFESLTLSLKLFRELFLALDNGSPEGLALHKRLKLLQ
The following text describes a protein:
Function:
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MTDAVGSIDMPDAQDEAPDSKKSRKGGKRGKKGPLKRLALFYRQIVAELRKVVWPSRNQLTTYTTVVIIFVVIMIGLVTLIDYGFSHAAKYVFG