lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Subcellular Localization:
Secreted.
Sequence:
MSKLLLLSLALWASCSPGNTGTALVDLSQPRVRCHASRYPVAVDCSWMPLQAPNSTRAMSFIATYRLGVAAQQQSQPCLQRTPQASRCTIPHVHLFSTVPYLLNVTVVHPGGANSSLLAFVAERIIKPDPPEGVRLRKAGQRLQVLWHPPASWPFPDIFSLKYRLRYRRRGASHFRQVGPIEATTFTLRNTQPHAKYCIQVSAQDLTDYGKPSDWSLPGQVERAPQKP
The following text describes a protein:
Function:
RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease.
Subcellular Localization:
Cytoplasm.
Sequence:
MDPSSDYHFLNQILWRRVKLTLVCGIFEGVLQHVDPNKIVVLKKVKNVETGRSVPGVKMFFGHEIVNVELLDEVEQGAVREKASSVSLNTERTKTDKMKDEDLNACEPPSPAPEAPSTSLLNGLKYSLSEEEEVTYNVIDQFQRKFGAAMLHIKKQSVLSVAAEGTNVCRHGKLCWLQVATNSRVYLFDIFLLGSRAFNNGLQMVLEDKRILKVIHDCRWLSDCLSHQYGILLNNVFDTQVADVFQFSRETGGFLPNCISTLQESLIRHLKIAPKYLSFLEERQKRIRENPEVWFTRPLSPSLLKILALEATYLLPLRLVLLDAMMSDLTTLVDGYLNAYREGSADRLGGMEPTSMELPEELRQLRDFQKQRRERAVKEYQVNAQGLLIRTVLPPKKSVTETSAKEGKVRGFLLCKNSRLDKAPSFMSHKDVNLLKEESKSKQATTEPQHLPPLEEEASEDARNKLICPESEGLEDQEITQKEHLKLPKQKFQTRLSLKEEIEQLLTVKNKEDLKCAKQDVSVSPSLPQETRGSPSDTFPPLRKAVLPTLPPCPALEKTDSWINPSLHLP
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Miscellaneous:
MISCELLANEOUS: Present with 1230 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLQDNNGPAVKRAKPSERLQCEYFMEKKKRRCGMTRSSQNLYCSEHLNLMKKAANSQVHNKNGSEAEKERERVPCPLDPNHTVWADQLKKHLKKCNKTKLSHLNDDKPYYEPGYNGENGLLSSSVKIDITAEHLVQSIELLYKVFEGESMDELPLRQLNNKLMSLKRFPQLPSNTKHAVQQSSLIENLVDAGAFERPESLNFIEFGCGRAEFSRYVSLYLLTQLTSLPAEHSGSNSNEFVLIDRATNRMKFDKKIKDDFSEIKSNSPSKPISCPSIKRIKIDIRDLKMDPILKSTPGDDIQYVCISKHLCGVATDLTLRCIGNSSILHGDDNNGCNPKLKAICIAMCCRHVCDYGDYVNRSYVTSLVEKYRAHGSILTYETFFRVLTKLCSWGTCGRKPGTAITDIVNVVESFEGAEPYTITIKERENIGLMARRVIDEGRLVYVKEKFTEFNAELIRYVESDVSLENVAMLVYKK
The following text describes a protein:
Function:
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i.
Subcellular Localization:
Nucleus, PML body.
Sequence:
MSEEKPKEAVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSIRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVC
The following text describes a protein:
Function:
Adds the first GalNAc residue on to the isoprenoid-linked bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) carrier in the N-linked protein glycosylation pathway. Acts first on the undecaprenylpyrophosphate-linked bacillosamine (Und-PP-Bac) substrate to yield the disaccharide.
Miscellaneous:
MISCELLANEOUS: N-linked protein glycosylation in C.jejuni consists in the transfer of a heptasaccharide (GalNAc-alpha1,4-GalNAc-alpha1,4-(Glcbeta1,3)-GalNAc-alpha1,4-GalNAc-alpha1,4-GalNAc-alpha1,3-bacillosamine) from a membrane-anchored undecaprenylpyrophosphate (Und-PP)-linked donor to the Asn side chain of proteins at the Asn-X-Ser/Thr motif.
Sequence:
MRIGFLSHAGASIYHFRMPIIKALKDRKDEVFVIVPQDEYTQKLRDLGLKVIVYEFSRASLNPFVVLKNFFYLAKVLKNLNLDFIQSAAHKSNTFGILAAKWAKIPYRFALVEGLGSFYIDQGFKANLVRFVINSLYKLSFKFAHQFIFVNESNAEFMRNLGLKENKICVIKSVGINLKKFFPIYVESEKKELFWKNLNIDKKPIVLMIARALWHKGVKEFYESATMLKDKANFVLVGGRDENPSCASLEFLNSGAVHYLGARSDIVELLQNCDIFVLPSYKEGFPVSVLEAKACGKAIVVSDCEGCVEAISNAYDGLWAKTKNAKDLSEKISLLLEDEKLRLNLAKNAAQDALQYDENIIAQRYLKLYDRVIKNV
The following text describes a protein:
Function:
Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
Sequence:
MFRGVMESAKEFKKVVDTISTLLDEICFEVDEEGIKASAMDPSHVALVSLEIPRLAFEEYEADSHDIGIDLEAFKKVMNRAKAKDRLILELDEEKNKLNVIFENTGKRKFSLALLDISASSVKVPEIEYPNVIMIKGDAFKEALKDADLFSDYVILKADEDKFVIHAKGDLNENEAIFEKDSSAIISLEVKEEAKSAFNLDYLMDMVKGVSSGDIIKIYLGNDMPLKLEYSIAGVNLTFLLAPRIEG
The following text describes a protein:
Function:
Mediates the hydrolysis of some nucleoside diphosphate derivatives, possibly using both NADH and ADP-ribose as substrates.
Sequence:
MSDHETPMVNGVVEHKIGEEVLPFVEDEYGGVIVEMTTPTDPKFFVATLRYSFTQWRSQGKKGVWLNLPLSQVNLVEPAVKEGFRYHHAEPTYLMLVYWIPESESTIPLNASHRVRVGAVVLNHNKEEKYGMLRGSGVWKIPTGVVDEGEDIFAAAIREVKEETGIDTEFLEVLAFCQTHESFFVKSDLFFICLLRPTSFDIQKQDLEIEAAQWMPFEDSASQPITHKNELFKVIHRICSLKMEKNYTGFSKKPTTTFFDDKLGYLYLNKQDMNNPIT
The following text describes a protein:
Function:
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. May be involved in lipopolysaccharide biosynthesis, potentially channelling CTP directly to CMP-KDO synthetase. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates (By similarity).
Miscellaneous:
MISCELLANEOUS: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
Sequence:
MSFKSIFLTGGVVSSLGKGLTAASLALLLERQDLKVAMLKLDPYLNVDPGTMNPYEHGEVYVTDDGVETDLDLGHYHRFSSVQLSKYSTATSGQIYTKVLTKERNGEFLGSTVQVIPHVTNEIINVIQSCADHHKPDILIVEIGGTIGDIESLPFLEAVRQFRCEHPQDCLSIHMTYVPYLRAAKEIKTKPTQHSVQNLRSIGISPDVILCRSEAPLSTEVKRKISLFCNVPEHAVFNAIDLERSIYEMPLLLAKENISDFLLNKLGFSPKPLDLSDWQDLVEALCDKERQHVRIGLVGKYLEHKDAYKSVFESLFHASVPANCSLELVPIAPESEDLLEQLSQCDGCLIPGGFGTRSWEGKISAARYCRERNIPCFGICLGMQALVVEYARNVLDKPLANSMEINPETPDPVVCMMEGQDSVVKGGTMRLGAYPCRIAPGSLASAAYKTDLVQERHRHRYEVNPSYIERLEEHGLKIAGVCPLGELCEIVEIPNHRWMLGVQFHPEFLSKLAKPHPLFIEFIRAAKAYSLEKANHEHR
The following text describes a protein:
Function:
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
Subcellular Localization:
Cytoplasm.
Sequence:
MPYIGSLKVNQFRNLADVDITPHSQFNFFFGQNGAGKTSILESIYYLSVGRSFRTHLPQRLIQDNTDRFLIFITLYNGTQFIPLGVERDCHGDRCLRINGETASSWSLAAKRLPLCSLSAMSHRFLLDGPRVRRQFLDWLMFHVEPSFFSIWQRLQRSLKQRNAALKAKLPLGEITHWDKMLVEDGERLHQLRQNVVTEFKPLFTQMLQQFLPAYPLIGHYFRGWSEKYSLMEQLQINLKQDLQRGYTQAGPQRADFRLTLGDLPAQDILSQGQQKLVTYALHFAQGLLLKEKTGISPIYLIDDLPAELDANKRDCVIDLVNCLESQVFISGIDPNEIRLPPHSTLFHVKHGKVAAL
The following text describes a protein:
Function:
Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MTAGLRIERFYAGYPKRPVIQNLNVPLIPRGKITVLLGPNGSGKSTLLRSLAGLNRAEGQLWLDGSDLMKMPFTQRAEKVVYLPQSLPAGVHLHVLESIIVAQRASGGRSNTRSEAQVMALLERLGIAHLALSYLDQLSGGQKQLVGLAQSLIRQPSLLLLDEPLSALDLNYQFHVMDLVRQETRQRNIVTVVVVHDINIALRHGDHVLMLQNGALIADGQPEEVITPQSLAKVYGVKGRIERCSQGTPQVLIDGLVTEPTM
The following text describes a protein:
Function:
Part of the ABC transporter complex TagGH (TC 3.A.1.34.1) involved in exporting the two types of intracellularly synthesized teichoic acids. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNPLIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKRINMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICMIAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLKLNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL
The following text describes a protein:
Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Subcellular Localization:
Secreted.
Sequence:
MGSLKTLSGGLLLGLCLTLLGWGAEGQWNGHPKKEISGSGPINLGQQQRGTWWPLMQTRENLTEVKSIKSMFQFRTFDPEGVVFYGDTREGEDWFVLILRNGLPEMQIGKADILVSVQGGPKLNDGKWHLVEISSQGDFVVLEVDGQKALVVGLKSKETMEVLTGQIRLALGGILVSVDKLFLPFQPEMDGCIQKGNWLNLSTPWETELIGEPWPCYQNIQPGSYFPGAGLAAFNTTDLPGHQTEEGGITIDIHGDSTKMEGTVLSLNTPGQELPTVTVKINNNPKKVILTILKRDTITEQSFSRLSLTLLKNQVNMDIDDTHLTFEIDSIPDFPRSWKEGMILAFGGLPGDGVSYSSIQYLKGCLEKIQVQGQDVDLDRALYKDLSVFSHSCPSEV
The following text describes a protein:
Function:
Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
Subcellular Localization:
Cell inner membrane. Cell membrane; Multi-pass membrane protein.
Sequence:
MSRMRNSWILPVSIMIALVLGLLPLPAVVQPLRPYWLALVLAYWVIEEPDRVGLGAAFVAGVLADLLYGGLLGEQALRLVIMTFILQRFRARMRFFPISQQALAIGGLLLNDRIVSSAVHLAVGEPTLPWSYWWAPLLGMALWPPVFVLLDAVRLGKRSKK
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity).
Sequence:
MLLFLSVPQPRPPGARTRAGAARVARWRRLRLQQLRRLRGLLRVLRGRPGAGSRRRGRMALCGQAAGAASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQLRICLRVSPAEQPRLEFLMRKCGWFVRELRVEFAAENYLSGGGPGDGGGADTGTGGEEVEALQLSARWLEVLRTYLELVLCVLVSIRNNRNLQKFSLFGDISVLQQQGSLSNTYLSKVDPDGKKIKQIQQLFEEILSNSRQLKWLSCGFMLEIVTPTSLSSLSNAVANTMEHLSLLDNNIPGNSTLITAVELERFVNLHSLALDFCDFTAEMARVLTDSNHVPLQRLSLLVHNVSVMHKSLDNMPNDEHWKALSRKSTSFRVYIMAFDIKSEDMLKILKPSIPLERIHFDSYITCVSGAIVDLISRQYDKFLTHFILMNDVIDTSGFPDLSDNRNEDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIDFDQGELADQDVDPVHNLIEQVSLGLGQPWHAVMDIESLSVFTEPNRHFYREMQSFSEDI
The following text describes a protein:
Function:
Part of the ABC transporter complex HisPMQJ involved in histidine transport. Is also part of the ABC transporter complex HisPMQ-ArgT involved in lysine/arginine/ornithine transport. Probably responsible for the translocation of the substrate across the membrane (Probable). Required to relay the ATPase-inducing signal from the solute-binding protein to HisP.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLYGFSGVILQGAIVTLELALSSVVLAVLIGLVGAGAKLSQNRVTGLIFEGYTTLIRGVPDLVLMLLIFYGLQIALNVVTDSLGIDQIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTHGQTFRRIMFPAMMRYALPGIGNNWQVILKATALVSLLGLEDVVKATQLAGKSTWEPFYFAVVCGLIYLVFTTVSNGVLLLLERRYSVGVKRADL
The following text describes a protein:
Function:
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
Subcellular Localization:
Nucleus.
Sequence:
MLELRLVQGSLLKKVLEALKDLVNDANFDCSSSGFSLQAMDSSHVALVSLLLRSESFEHYRCDRTMSMGMNLNNMAKMLRCAGNDDIVTLKADDGSDSVTFMFENPSQDKIADFEMKLMDIDSEHLGIPDAEYQSIVKMPAVEFARICKDLSSIGDTVLISVSKEGVQFSTRGDIGTANIVCRRNTTVDKPEEAVMIEMEEPVSLTFALRYLNSFTKATPLANQVTISMSSDLPVVVEYRIEGMGYIRYYLAPKIEEEDEAATISKPETEPKHTAKAKPKADLKPNFEPNPESEMKSEEDEGSVIEIKDKDKSVFVINDEVQNSPVKSKAREETNTPKEPKIETMELE
The following text describes a protein:
Function:
Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.
Sequence:
MTTFTRIPDGETPSISIDASRRLSKIDPMIYGGFMEHMGRCIYGGIYDPGNPLSDKHGYRTDVLGALRELDIPVIRYPGGNFIATYHWEDGIGPREKRPDRPELAWLGTETNEFGTDEFMHYLSVLSEGKEKRVEPYFCLNMGTGTLTEALAWVEYCNGTRNTYYANLRRKNGHEEPYNIKYWALGNEVWGPWQVEQMTAEDYAKKALQWSKALHLLDPTLQLILCGETGLSPWDLTVLLPNIHHITMHSIHIYSTSSKHLPNALSPLQAETAIESAASLIQIARIQAKIPPSVPVPKICFDEWNVWDPLRAPGEEGAEEKYTLSDALAVGVWLNVFIRQSRYVGMANLAQSVNVISPLMTSKNGIIKQTTWWPLWLYSKYMRGWTLGLHVRGGAYEGVQEPKWLASVVGEQGGASWLDVAGSIDEDGVISLCVVNVSEEESFETDLLGVKGEVQVFTITGDNVTVVNTAEKEEVSVKESKWDGKGKYTFGKHSLTMLRWATGEKVVEVKKGEGERLDTRKLAWAGDRELDKS
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MSGDKELSEGDCTKIFLNTLGITEEDLPKYYDHLKDHDKSYQCHKNFKNSAISVFCEQCSRSQSNLARSCICVPCYLNSNHKGHNVSYYVTENFICDCGNPVNWDPDNPCSLHKKPTTNEDTLTLDSEERSTLEKAIKNSITSTCCPFEIFSQVVNIGSGISHLISQSLIEIMDFDKTFRTFVHWETDQTSRAINFFCSMLVESDFSIYYGEAFLDYYQDFLTDTIKAVAKDCLSNEVANYAILAQTAFSFFTKRFISHSKKFLEPEKYNLVSWFQDKIKILLECRFLPLPKFKEANILRETINYMAGLVQLIAEQDTTKHLLTEILNIIFSYSYVLENDFTFTKVLHDYDNDETMMGLVFYYLGLLPYSVFNYMGQKDLFTKSVLDDYYLFLQNKILQDEYQDEDYGGVLDGETEITPCLSLHAALSYFLWKNLENAQNILSEFCQEKNIDLNYFLRMSCLLVVRHFATTLLAMLNCFKGTSEFSIRAVFFSIVPINVNNILKPLFRLIQMCFAMTDEKGKFLDMIWKTFSQKSDIAYKEQIQNSFIYFLDCLLFDRLIFKNDDLTMRRITYSNKLKIMGRCKFNDIKYPGMWNEARLEKDFFDYAVMEKSNSGNFYKLKSDKYVSPFAIWISLRDNLKLQSMIIKGDKFLTAPEFEDIGGYGFDKVFDEPVLEEILSDFFVSNNATAINMGLPIIKNMSNLSPHFTSVICGSPIGEKFLILEGKIKSENSQEISEKPPNSIQKSIMLNYMKNNELDELLKYDDEEDENEHEKHHHHGHDEDDINQTCFLCLSDSKTSNLCYPVYFTKTTVYSEIEYKLCGSELKENKKLPQLVMCQHLIHRMCIDSQVEVCPIDKDLINAALPIIKDVNQVDDSTESDINEFVKMVFCNNDDPEKMLEKRFENILSLLCRHVSISEVRYRTNPKCYKQESFYLITENLYKIAKFLKKKDNVSKIFSNDIFETIVFDYLFDDINSNEFTNLLKDLKPLRLFVILRRVEILKNVILKETETVNFENILTSENLMPKYKVNLENVTLQKYTLDLPKNYIDIFRDERCQNAFVFDASWFKILQSDKIIEYESLKSLEKHDEANPMLVFAINERIATEVFIISTNPRAFLGQKSVYLNEYGEENIGIKSNGFLTLSEEKCDEIIDDYLSGEWMHQLSREQIQAAMDIFNFGD
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Sequence:
MSNERVSFQMDDASIHSSHTEPMDDANTGSKHVESSDNFGADSNPNHLESKDDVSIRVKQRIETNYGQGGFHPVHLNDTFKHDRYKVIHKLGHGGFATVWLARDIKRERYVALKVLASRLSSGSPEVSILRAMKDSSEHIGKSHVMSLLDHFTHRGPNGTHLCLVSEVGGPSIKEFNDCPGEYKGSRRLKASVARDVCSQVINGLDYIHITGIVHGDLTPANILLRLANIDEWTEDQIHERLGVPQKQEIDRSSSQLTASASSFPDYAVVAINMKEVNPIWLSDKIIIIDFGIGFFLKKSSLDFGTPKSYCAPEFLFGGHRSIASDVWALGCTIFEIRTGSRLFKYNGIPTKDEMLIATVKLLGTLPDKWWAEWREGLEWYKKQPVITTAMRVGDILEQILETGAHDGDVPERTKRNIEALNCIRDLKKNSLNSIPERTEELVRIAENMRTSEAGEVLRLVHSSGQRQSASGSLEDIKVSGSSSDPKGSGSKSSEAKSSEARSSEAKSSDAKSSGKTPSSEGVSTGMPEIKTATVFSGVVEEPKIEASANASDSKDDATRDMVISSDKYFLHCGPAHLHTFLEPPGLRISVAEAKSFEDLLRKSLRYLPEERSTASELAKHIWLSGMFNETDLKPASSTSLAI
The following text describes a protein:
Function:
Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.
Subcellular Localization:
Cell membrane.
Sequence:
MVLCEATWVPRSATAAPTRLISRPRGEQERSTTMTLTSCKRCLQQLAAVSRRSLTNLSYEDLAKECREDSGWDSDVDSLSSGEEEEAVGTAIHRVVLLGGEGVGKTELARQFVGADGGYESDSDGGDCDDPFLDPDTMPGYGLRNAFQKDVKVDGSAAVMSITDIPATELYDSDDESFLNAGDAYIIVYSSTDRESFRRAADVALSLRRAKKTAHTPIIIAANKSDLERRRQVSSEEGVECAVGLDCKFIETSATFNHNVDELFEGSVRQLRLRTEARRLANQQRRLRNRIRSARRTEPRREPEREKSYFERFMEFLERLLSSKKDRVARMKAKSCHNLSVL
The following text describes a protein:
Function:
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein.
Sequence:
MIHLWKLVRHMRQLELHRLILLLIAFSLASMCFLAYYVTNSPKIKEPPPLPFSDCSSQQRTVVQPQASWRIAKSVDTSRTEPVVLVFVESIYSQLGQEIVAILESGRFKYRTEIAPGKGDMPTLTDKDRGRYALIIYENILKYVNLDAWNRELLDKYCVEYGVGIIGFFKANENSLLSAQLKGFPLFLHSNLGLRDYHINPNAPLLYVTRANEVEQGPLPGDDWTVFQSNHSTYEPVLLASTKSAESIPHLATHKALHATVVQDLGLHDGIQRVLFGNNLNFWLHKLIFVDAIAYLTGKRLCLTLDRYVLVDIDDIFVGKEGTRMKVSDVEALLNTQSKLRTLVPNFTFNLGFSGKFYHTGTDEEDEGDDMLLLHRKEFWWFPHMWSHMQPHLFHNVTVLAEQMKLNKQFAQEHGIPIDLGYAVAPHHSGVYPIHSQLYEAWKSIWNIQVTSTEEYPHLRPARFRRGFIHNNIMVLPRQTCGLFTHTIFYNEYPGGSKELDKSIRGGELFLTVLLNPISIFMTHLSNYGNDRLGLYTFESLVKFVQCWTNLRLQTLPPVQLAKKYFEIFPEEKNPLWQNPCDDKRHKDIWSKEKTCDRLPKFLVVGPQKTGTTALYSFLGMHPAVTSNFPSPVTFEEIQFFNGINYHQGIDWYMDFFPMPSNASTDFMFEKSANYFDSEMVPKRAAALLPRAKVIALLISPADRAYSWYQHQRAHNDPVALNYTFAQVVSAGPHAPLELRNLQNRCLIPGWYSVHLERWLTYFPANQVHIVDGQELRSNPATAMDSIQKFLGVTPHLNYTQALKFDEAKGFWCQLAENGKTKCLGKSKGRKYPELEPSSRSFLTDLFRENNIELSKLLNRLGHPLPTWLREELQNSNRS
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDFQLLQIMFTIGKFFALTPRSIKLEKQTFIQKFYAVAFFLALSIGVVVSIYSKSFHRNEIHIKIVLMFFKEASLYCFNYYVIVVTTFYKRRTWTRLLKNLESCAKIKKTKRYCYYYYAFFGVHLAYGVVIIYSICVQTEKSVFDFLCRHTVEYFQNYIHFFYQLLLYLITDMILMRYKELNRVILDNMSRNHLFLVRRTETLAQILNQTVNFYNSAFGWPIAFLIFFATLDFLDNVDTIMYEKTNVTFVHLAVLNILRVGKNFVCLLSLIILCDCVVKEAQKSLVLTYEMRWYCQTATMEEKQELYEFSNFVSQHLPKFSAANFFDIERSTILSVLGTACTFLIIIVQFRNS
The following text describes a protein:
Function:
Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V).
Sequence:
MAGLGSPARTLRGLLRELRLAGARNDTAYRDTAAYRYLLHAFRAHRVTGEKLCRAQHELHFDAATYLCLLRSVREHVALHREFHGRGERSVTESAGMVGLQLPRQPGGKGWEP
The following text describes a protein:
Function:
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
Sequence:
MKTTDVRVRRAITAMAGGHAVVLTGDPNGDGYLVFAAQAATPRLVAFAVRHTSGYLRVALPGAECERLHLPPMCDRDTTHCVSVDVRGTGTGISASDRAWTIAALASATSVAADFQRPGHVVPVQAQADGVLGRRGPAEAAVDLARLAERRPAAALCEIVSPDNPVQMAHHAESVEFAVEHGLAMVSIGELVAYRRRIEPQVVRFTAATLPTWAGASRVIGFRDVYDLGEHLAVIVGAVGAGVPVPLHVHIECLTGDVFGSTACRCGEELNGALARMSAQGSGVVLYLRPPGPAQACGLFARGDAATDVMPETVTWILRDLGVYAIRLSDDVPGFGLVMFGAIREASTLAAAG
The following text describes a protein:
Function:
Possesses tyrosine phosphatase activity.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MRRLLEPCWWILFLKITSSVLHYVVCFPALTEGYVGTLQESRQDSSVQIRRRKASGDPYWAYSGAYGPEHWVTSSVSCGGSHQSPIDILDHHARVGDEYQELQLDGFDNESSNKTWMKNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGSEHSVNGRRFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHEKETFLDPFILRDLLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSVEYLRNNFRPQQALNDRVVSKSAVRDAWNHDLADFLDNPLGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFTKDSDKDLKATISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGVPTASPASSADMAPISSGSSTWTSSGIPFSFVSMATGMGPSSSGSQATVASVVTSTLLAGLGFGGGGISSFPSTVWPTRLPTASAASKQAGRTVLATTEALASPGPDVHSAPSKDSEGTEEGEKEEKSESEDGEREHEEEEKDSEKKEKSEATHTAAESDRTAPAPTPSSPHRTAAEGGHQTIPGRRQDHSAPATDQPGHVAPDLDPLVDTATQVPPTATEEHYSGSDPRRPEMPSKKPMSRGDRFSEDSKFITVNPAEKNTSGMLSRPSPGRMEWIIPLIVVSALTFVCLVLLIAVLVYWRGCNKIKSKGFPRRSREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESVPIIPIPDDMEAIPVKQFGKHIGELYSNSQHGFSEDFEEVQRCTADMNITAEHSNHPDNKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIIMITNLVEKGRRKCDQYWPTENTEEYGNIIVTLKSTKVHACYTVRRLSVRNTKVKKGQKGNPKGRQNERTVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPDMGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETAVSSSQLHSYVNSILIPGVGGKTRLEKQFKLITQCNAKYVECFSAQKECNKEKNRNSSVVPAERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFVYKAMLSLISTKENGNGPMTGDKNGAVLTAEESDPAESMESLV
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MEPKVILKSNDGQEFDLNENLFSQSLLITRSLNKQNIVLIEIDTANGSTVELILNFMEKQLERISSGEDSSDFIKWQERFLFKKHYDFDSILQTACALEIKHLVDLVCKAIAEAMAGKSVEEIRKILHITNDFSAAEEHEARREIDWAMI
The following text describes a protein:
Function:
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
Sequence:
MGVDWLHLDVMDGHFVPNLTFGPPIIKCLTQRLQNRTFIDLHCMIQEPRKWIKDLSNAGGHQMTVHYESDIGNIEELSQMIRNAGMRPALALKPKTLIDHTLIEIFDKQLFDMILIMTVEPGFGGQKFMADMLPKVTQLRQRYPKIDIQLDGGVNCDNVISCYEAGANVIVSGSGIVNAKDPQQSINYMKECGCQHFKW
The following text describes a protein:
Function:
Metalloproteinase inhibitor that acts on both matrix metalloproteinases Mmp1 and Mmp2 in vitro. Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor (By similarity). Required for wing maturation which is the final step in morphogenesis of the adult fly. Involved in the negative regulation of developmental tissue invasion for imaginal disk eversion during metamorphosis by inhibiting Mmp-mediated basement membrane (BM) degradation. Required for oogenesis and for the long-term maintainance of germarial structure and shape in the adult ovaries. Required for maintaining composition and biophysical properties of the extracellular matrix (ECM), and for the normal organization and cyst production of the germline stem cell (GSC) niche.
Subcellular Localization:
Secreted.
Sequence:
MDLRKHLGLLTLLLVAVFAFYGRPADACSCMPSHPQTHFAQADYVVQLRVLRKSDTIEPGRTTYKVHIKRTYKATSEARRMLRDGRLSTPQDDAMCGINLDLGKVYIVAGRMPTLNICSYYKEYTRMTITERHGFSGGYAKATNCTVTPCFGERCFKGRNYADTCKWSPFGKCETNYSACMPHKVQTVNGVISRCRWRRTQLYRKCMSNP