lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity (By similarity). Exhibits transactivation activity in vitro (By similarity). As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (By similarity). Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Involved in the display of nurturing behavior towards newborns (By similarity). May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (By similarity). Implicated in behavioral responses related to morphine reward and spatial memory (By similarity).
Subcellular Localization:
Nucleus.
Domain:
Binds DNA via bZIP domain; DNA-binding is under control of cellular redox homeostasis (in vitro) (By similarity). To enable DNA binding, the bZIP domain must undergo a conformational rearrangement which requires the reduction of the interchain disulfide bond between FosB and JunD (in vitro) (By similarity). The bZIP domain is able to form homomeric oligomers via formation of interchain disulfide bonds under non-reducing conditions (in vitro) (By similarity). Under reducing conditions, the disulfide-bonded homomeric species dissociates into monomers (in vitro) (By similarity).
Sequence:
MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPAVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARLRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSASTKEDGFSWLLPPPPAPPLPFQTSQDAAPNLTASLFTHSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGTQRPSGSDQPTDPLNSPSLLAL
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH.
Sequence:
MGPFSSASDRNSAAATAAPATATATPSPLSKTPSAATSDDSSTSKKFLKRLNILPLRSRTRNIADFHIRPDDPHRKYSAGDHVQGAVVLTVVKPVRITHLTVLLHGYVRVYKGPGAQNNEPVRSPAEIKNISSRGERKKYYNGYASLFQDEQVLSSDGRLEPGRYEFNFDLLFPEKGLPSSIDFERGTISYMITATLTRPTSVAPTTSCERKIYLMEQLDVGPLAPPKAQTVDLRPISKRAKKKRPAGGDRRSVISSERLSADVPAESLSDGDSARINDTSTEGSLSIVGDDVGQEGFSQAPRSVSHSEVRSLSGDSAASLSTHPSRAYSETNQLAIVGSAMTGKRISFADERTIKLRVEVLKGGCLPGDVIPVKVSVNHIKMIKSMHGVIVTLFRQGRIDSSPLQLSKEDWKKSESDDYYYPKSRTGLSGLSLSSAGSCSMFRKDLSQAFAPLITDPVNFSATLTTSVRVPEDSFPTIKGVPGEMISFRYFVEVIVDLGGKLANHLQGGASSGSRVGATGVVGTPFENVGTLPSWGATGSTSILDTDRLKRIQGVIPGYYEVIVGTTDSNRSRGKGPQRPSLTHTPSVTGGSNYVENEYNEKGGWPNSMHDDDGYGPESANPHDDYASYPPQTTYPHGYVQQPPYWNYVPDSSQHEQAIPAPHYIPPPDLPDENSLTEKERIRRAEQRLLPSQPPIAAASSSSFSAAVPSPSASSHVPDSSLLLNGDNIYDAEDDVPTPAATPATASPFDHALAPVYTPTPAEDLPSAPTLEELDRPPPISRGPSHHPPSTTEDKQELERRRLLAEASAPPEFPEDYIPDEGGGPVTPAGPSGSRAGPSAPPPAPPVAFEPSAPVLFENDEDYHGGGYTAGGPSFPSAASGNGGHEEETVPEYTYNNHRPGSVGAVTVVGNPSSPVLAPASAFFPASGSGNVHDSPREQGQQARSDSSSPPPIEYLPRYER
The following text describes a protein:
Function:
Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle. Note=Cell periphery. The polarization of EXO84 requires actin cables (By similarity).
Sequence:
MVDFSLRKARNNWSKLSSPGKTRQQGSPTKLKSNAYEDFVSPRDTLQLPEIGMKDRRKVGTSMQRRLSVHNAKYIPPPIDYASAPALPTAVELPVRDNSLLSSELMKPNHRRPPVDIYGGRSLREILSNPQFQAKRFVHEKLGDATALEIDHFASNLNHLSQEIEQEIKSNINKSYNELMQVNKELAVASTELKDLRSKVQQLQVVMGQFTAMAEKRLLLEKEHFRQSNTSVMTTKSGSTGSGLLPPVKSGAAKKDRSSVIILEKIWTNELSSLFRSVEGAQKYIAPAPGRRILLESNDWMEINIATLKPLHATRIFLLNDMILVAVCRSDKKGELVANQCCSLRELTVAEESNYTLSFHFGNKHHSLYRSRTPTGYTALLNEIKSAKDELRDIYQAEEDNARKLRDSFTYLQSTQQSPSRDISSPARGHSRQRSLGTLQNTPSRASTYQENLLQNISMSMHTRSRSGGVNQTAVKLNLVYEELEELSVPVTRMNFGLAIKKLHSIENILKGITAEAEGEVMLLNLLRMKCNQTRTLITQKLTHVINTEYSDANKLESSTKSLILLGMPAEALQLFLHNRSNFIQDLVLQVGVHDNSNSYITQVAVIRCQTIKKVAIQFQKLFEGTTAKYSSVLVSWCNDEVDKHFFLMKKQLINDDQLTPQAIKISRKQIDELKSVGMDFVYKLDDFLKIHSNKIY
The following text describes a protein:
Function:
Required for nuclear migration.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Localizes to the plus ends of microtubules.
Sequence:
MVDDEDDITFDSPEEEIAHYREKYRQALDMLTDTRAELEEFQQSSKELEDEMEQELAANDKQQADLREKIKRLDAEKEEWRTKHIALQKMHSSTTSAMQREMDNLRSERDKTLVALRDLEMGNDELERNERVAISSLLDLESKYNRAIEEKTLLEQDLAQKDELETETQRLKDELREANEEISILKDQLARAIATPPSSVSTSSPIHDAACDLSRIHLSDDINASPLPPPVPSKNKSITPEGHSPRRGLSRSGTMSSIPVASPSTKRFSQQIPHSPSFSTLSRSTTSRNLAAAAGTPGSPALARSRSGIPQASPARGIVLASHQQTKSRGFKLLHDLQARLKATDDKLGGAKVPRRNVSNPASVFGVGKRVTSTTSTTSSTTTAPAPHARVTALAKDHNTTPTAQSQQFPGSGIMSPGWVLVGEGEGEDTPTGPWSMTLPAEPNSPLDPTFRSSSTTSNRSLPSRPGIPSPLASGSARSTTSGTAQRQAGQRPSSRLGLKASRRDSEARPLSPSMIPVPSFSSRPMSPDVYQPLRSATPTSGFSSFSASASTSNPPRPNSRTGKRNPIGRGPPPLSSSTRLHHQRSRQSLSGAGPTPTTGADKVERAKRGPRRSSLSNMDKPSLMSASSGSRTPSGRPTSVHVFRETPPPVPRIPSAILKESKVKK
The following text describes a protein:
Function:
Prolactin acts primarily on the mammary gland by promoting lactation.
Subcellular Localization:
Secreted.
Sequence:
MNIKGSPWKGSLLLLLVSNLLLCQNVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITRAINSCHTSSLPTPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMEEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWTGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
The following text describes a protein:
Function:
Probable ATPase which may play a role in nucleosome organization.
Subcellular Localization:
Nucleus.
Sequence:
MRRRARSIRFSSDDNEDNEEDDDYYSNAHSEKSEDHSNHIKVSHFDPSSYKQKLVSVRETQRNRKFSSLQKHLNTETPSFSVSIENPSKPSAAFNDASLGKKSTEHQIDGIRNGSSNLQMEGNDKELDTDNNEDESTTFKDEEDDLISPKSYLTSSKTFSYPKAPTESTNGDYLDEDYVDGQSDPESSNASDSDFADSPDDLTKVRSPIPSRRGRRKRKMRGPILPVKKNLRVKKAMSPLRAERNSPDFRRKLRSRDNRPNYHLFDYYNEIASSPNPSTTKITYNPPKLPMKDFATLPIGYQSTCDSDETSELSSTSSEQTSDVEGLNAYNNLGASSDIENAPSSQLHFGHIDEKTIRSTDPFANRENLDFNSIGGLEDIILQLKEMVMLPLLYPEVFLHLHITPPRGVLFHGPPGTGKTLMARVLAANCSTKNQKISFFLRKGSDCLSKWVGEAERQLRLLFEEARRVQPSIIFFDEIDGLAPIRSSKQEQTHSSIVSTLLALMDGLDTRGQVVVIGATNRPNDLDPALRRPGRFDREFYFPLPNKQARMKILEINSLHFSPKIPESYLLHLAESTSGYGGADLKALCTEAALNAVRRTFPQIYTSSDKFLIDLNEISVSICDFVVASEKIAVSTRRSDVKPNIPITDSHKILFKKSIEVITSKIRRLLKLDVYLPTVESLQKLPAEELMRQKEINSLKTTMSFRPRLLITDIYGYGCTYLSKVLFSMLDGIHVQSLDISELLMDTTTSPRSLLTKIFSEARKNAPSIIFINNVEKWPSLFSHSFLSMFLLLLDSISPLEPVMLLGFANTNQEKLSSTVRSWFPSHRSEYHDLSFPDYSSRYSFFHYLLKRISFLPIHQKSAEAASVDILPKVLPVSKTSDLTDKVNRRQRKNDKKIKNKIQVKLSSILEMLRSRYKKFKKPIIDLNDIYIDESNERVVKGKSKDNFEYFLSGNTVTRKKDNACFKMMNFEEIERRLWSGRYCTPKEFLRDIKMIKQDAILSGDVNLKHKAKEMFAHAELNVDELIDAKLLYDCCQVSKREKAYKQLKQKKLNNAKDAHEMQESKNEETFVRNDVAQEDNFIELSSNEVRNVSNDEHKHTLFHGQSLTHNNLIAVTPPSRTGVEHKEENKKYDNVNIQKTLAKCAEEFAEHTNFNKVELLDFVYSKLSSTIWENREEHDLLKIVRDVRQTFFRSLEDMGV
The following text describes a protein:
Function:
Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.
Sequence:
MLKKWLNKMLPSGRSSKKAESKTVIPAERHNIRAEMLSFAAENVIRRLKGTGFQAYVVGGAVRDLLLGIEPKDFDVATDATPEQVHKLFRRSRIIGRRFQIVHVMNGAETIEVTTFRGGAKVHQNARGRIMKDNTYGSIEEDAMRRDFTCNALYYDPEKEEILDFHNGIADVAAHRLVMIGDAAERYQEDPVRILRAIRLSGKLGFELSEETAAPIAESICRLKHEPVARLFDEIMKLLFSGHARECLKRLNGFDIPDDIHLLLNALRVSDGIAGKMTVLALKNTDERLRADKSVSVGFVLAALMWPELERHWKSNLQQGLKPAPALSDAINTMRETVERGWGVPQRFSATMREIWMFQPQFENRKGARPHKLFAQARFRAAYDFLLLRAETGNADRALAEWWTAFQTASTEQRSEMTKNEAAARHEKNEGQAKKRRRRRRKPKPKVVGTDWE
The following text describes a protein:
Function:
Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein.
Sequence:
MAPMGIRLSPLGVAVFCLLGLGVLYHLYSGFLAGRFSLFGLGGEPGGGATGPAAAADGGTVDLREMLAVSVLAAVRGGDEVRRVRESNVLHEKSKGKTREGAEDKMTSGDVLSNRKMFYLLKTAFPSVQINTEEHVDAADQEVILWDHKIPEDILKEVTTPKEVPAESVTVWIDPLDATQEYTEDLRKYVTTMVCVAVNGKPVLGVIHKPFSEYTAWAMVDGGSNVKARSSYNEKTPRIVVSRSHSGMVKQVALQTFGNQTTIIPAGGAGYKVLALLDVPDKSQEKADLYIHVTYIKKWDICAGNAILKALGGHMTTLNGEEISYTGSDGIEGGLLASIRMNHQALVRKLPDLEKTGHK
The following text describes a protein:
Function:
ATP-dependent chromatin-remodeling factor that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification.
Subcellular Localization:
Nucleus.
Sequence:
MSDDQHESIDGDETMEEDSMLAEGHEDGEEDVGEDEEEVETEESQGVPTTSEKKKPPPKKKKGGKKSSKKKNNCDYPDPYKSTSAEISAAIGLTDVDVDYEQEEFQSITNLKNFSSLVKPYILKVNPGTNVTKMYPLFQVKYKEFQDHMTAHGKSIQKQQRAKFVPVPVPVTPQEKIIPQKTRSSARRKRRDGSDGEGGGHDSDQEFEALIKQHEKQQDEAEKGKEEARINRAAAKVDKRKAALESARASKRARKEQGVVEENHQENCEVCNQDGELMLCDTCTRAYHVACIDENMEQPPEGDWSCPHCEEHGPDVLIVEEEPAKANMDYCRICKETSNILLCDTCPSSYHAYCIDPPLTEIPEGEWSCPRCIIPEPAQRIEKILSWRWKEISYPEPLECKEGEEASKDDVFLKPPRKMEPRREREFFVKWKYLAYWQCEWLSETLMDVYFTALVRMYWRKVDSENPPIFEESTLSRHHSDHDPYKLRERFYQYGVKPEWMQIHRIINHLSYAKSQQDYLVKWKELSYEHATWERDDTDIANYEDAIIKYWHHRERMLNDEVPRNVQKMIAKQREAKGLGPKEDEVTSRRKKREKIDILKKYEVQPDFISETGGNLHPYQLEGINWLRHCWSNGTDAILADEMGLGKTVQSLTFLYTLMKEGHTKGPFLIAAPLSTIINWEREAELWCPDFYVVTYVGDRESRMVIREHEFSFVDGAVRGGPKVSKIKTLENLKFHVLLTSYECINMDKAILSSIDWAALVVDEAHRLKNNQSTFFKNLREYNIQYRVLLTGTPLQNNLEELFHLLNFLAPDRFNQLESFTAEFSEISKEDQIEKLHNLLGPHMLRRLKADVLTGMPSKQELIVRVELSAMQKKYYKNILTRNFDALNVKNGGTQMSLINIIMELKKCCNHPYLFMKACLEAPKLKNGMYEGSALIKNAGKFVLLQKMLRKLKDGGHRVLIFSQMTMMLDILEDFCDVEGYKYERIDGSITGQQRQDAIDRYNAPGAKQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRLGQKHKVMIYRFVTKGSVEERITSVAKKKMLLTHLVVRAGLGAKDGKSMSKTELDDVLRWGTEELFKEEEAPVEGADGEGTSSKKPNEQEIVWDDAAVDFLLDRNKEEEGQDGEKKEHWTNEYLSSFKVATYNTKEADDADDDEDETEVIKEGTEEQDPNYWEKLLKHHYEQDQETELQKLGKGKRVRRQVNYASENMGQDWSAQNNQQQEEDDGSEYGSDNGELLQTDEDYEERRRRREERSEKLPPLLAKVNGQIEVLGFNPRQRKAFYNAVMRWGMPPQDLTQSSWQVRDLRNKSEKVFKAYSSLFMRHLCEPVVDNSDSFMDGVPREGLNRQAVLSRIGLMSILRKKVQEFEKFNGEWSMPETREKMLATAAQASVSNLPGMIKIKEEPIDIDETPMDVDQSNITKTEELASEVKVEEEPKAPRLPYKFNICDGGYTELHSLWINEEKVARNGKEYEIWHRRHDFWLLAAVAVYGYGRYQINFQDIMNDPKFSIVNEPFKQTGADPATNFADVKNKFLARRFKLLEQSLVIEEQLRRAAHINKQQSPDQVGQLAQHFSELEHTADAHVNIARESNNGNRNANAILHKCLAQLDDLLSDLKTDVARLPATISQVRPVTERLQMSERQILSRLVVAKDPDAAPSKPALPPSGPFITPLFNQNFTTIQPKFPSLFDCNLSPDDEPIDIEGSISAAVAEASRASSIAATKDEPMDTSDKDIPSTSAAAGSSYPRY
The following text describes a protein:
Function:
Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.
Subcellular Localization:
Cytoplasm. Secreted.
Sequence:
MAAEPLTELEAAIETVVTTFFTFAGQEGRKGSLSIHEFRELVTQQLPHLLKDVGSLDEKMKSLDVNQDSELKFHEYWRLIGELAKEIQKERALEIRKK
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MDLKEVKRSKEAEAMKSCSYCHTTTTPLWRSGPSGPKSLCNACGIKYNKKRRQILGVEKKRRIEKKSIEIGKLMGFGGKLREEEQAAILLMALSCGSVGKLLC
The following text describes a protein:
Function:
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MTPRLRLQPESVGIGMTSQRVRDRLVERLRESGIQDEATLNAVRTVPRHLFIDEALASRAYEDTALPIGHGQTISQPWVVARMTEAVLQVAPKKVLEVGTGSGYQGAILAALGLEVYTVERIGDLLRQARKRFRHLGMNVRSKHDDGRIGWPEHGPYDAIVVTAAAPALVDALVDQLAVGGRLVAPVGGASSQSLVQLTRGADGEIAQEVLAPVTFVPLLSGMLD
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MKEEQNSCRAFLDMSIDDVLSGRLVFELFDDVVPQTVENFRALITGSCGIDTNTGVKLDYLGTQVHHVDHNNNIIVLGELDSFNLSSTGTPIADEGYRHRHTERGLLTMISEGPHTSGSVFGITLGPSPSLDFKQVVFGRAIDDLSLLEKLEAVPLDDVGRPVLPVTVSFCGALTGEKPPGRQQLLAAADDSASSEHVSCAGEE
The following text describes a protein:
Function:
Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport.
Subcellular Localization:
Early endosome membrane; Peripheral membrane protein. Late endosome membrane.
Sequence:
MNSSNLNYLDELVKEYLIFRGFTQTNHYFSLEKKGDKLKGFQVDRILEQINIYISSYDINHLVELWNFLDITFFSKIDYNKSNAYNNNNNNNNNYNSNHNSNGSYTSYRNNNNDLQSTIKKLSSSLRKYYVIYAINNNKIDKVKEFFDQYSLELLKDPDWQSWFALPYIRNPQSDPLFEIYFSKTWSEAFSLSLRNFLSTIFKNIPLPKILQFNLERQNRKRLETQVENLLSINEELRSQVDKLEYQNKRDQNNSGSNNNSNNNSNSGFTIGNVSQRKESNVNNFNSGNDLNSSNEREVNSFSRVSKRFEPRSTSSTNIAAMDDDDNKPMIGIGRSRKSISTNSVNSNNNINNNNTSNTNTNTNTNTNTNTNSNSNTNTNTNSNSNTNTSNNNSNSNNNNNGTNTNVTNNNGFQHLNLSGFEMTEIDENGFKKKSSNGLNGSDGIENGELVYNIESQEVCTSHSSAITRCKFLSNGSKIASSSIDGTVRLWNVGFSSRQTTIYCLSEVASLEWENRSKLLLCGTIDSKIKIWNSLTDKAIGDINTSIEFPRVEDIACNPNGNSFATSSINNGRTDGVVYTWNLRTLKTEEKLSSSGAVINSMSFNSTGTLLSTGCVDGTIRIFDIKSGSPIAGWQAHSNEILSVQFSSDENRLYSLGKDGKLYQWNIHSMGKPVKEYDYPGFLVDPHRTTKISFNHNQSSFLVGTNNKFALLYNIDQSSPILQISGHTGPVVTCDWNSSSQSDVIITGSLDKTIRLTKLSKSFNNL
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MSESSTYFEKQRDMLIQEIGVSIESVVYNLDILNRSLNGSISVGKEFDNVGRLWSHFYDGLNQLKERNNQEETNKNDQGDANDDDSSSDEHGSSDEEIDQDQEN
The following text describes a protein:
Function:
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.
Miscellaneous:
MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
Subcellular Localization:
Secreted. Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
Sequence:
MSLCSLAFTLFLTVVAGIKCNVTDVCAGSPGIPGAPGNHGLPGRDGRDGVKGDPGPPGPMGPPGGMPGLPGRDGLPGAPGAPGERGDKGEPGERGLPGFPAYLDEELQTELYEIKHQILQTMGVLSLQGSMLSVGDKVFSTNGQSVNFDTIKEMCTRAGGNIAVPRTPEENEAIASIAKKYNNYVYLGMIEDQTPGDFHYLDGASVNYTNWYPGEPRGQGKEKCVEMYTDGTWNDRGCLQYRLAVCEF
The following text describes a protein:
Function:
Probable chloride channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGVTPGEDAYSIPFLARLLHSLPHLNVTFHQVNNSFDPHSPVYLESLGILGSLPAAWLILTLLVLLIYLLTRCCDRKPRPSRSISALKVSLAIVSVLCCAAIGLGLYGNDDLHNGVVRLLEEGRQVDILVAKIRNQTEAIERQLRVQVEAQLVNMRDIFDEPVSNMSMFKPALNYLEKTMGNNTMAANAAQDIRQPLLGMNLMPKIVVGEKVEAIRWPLTMAVLSVLLILCVILLVGVARHSRCALIAFSVCGLLAVIASYLMASVYLASSVALGDLCIAPDKFVEDQASTELSKDILRYYTSCERARANPFTQRLREAKTAIENMRSNLNSLRQPALNLFPKKQLDTKFSSLKNEVNSADTSVTILTTSVDCRALHAHYLRGARALCNVGLLGLTMMLVSAVLAGLLLTALVWVDSHTWIYIRKRKDYHQVNENDPYLPPPQASQAIAARTLQRSQGSSYPPDTPPPSYTSALMHNRTHASAPFPHEADSLLDGCDMRPPEHHRGAHMSHLRGHTLGRLPSHHHEPALSGPNNGKYATLSKQCKTLESSDFY
The following text describes a protein:
Function:
Protein-lysine methyltransferase.
Sequence:
MIHFNLLETQLTPLASFQEIMKKTSIYHLPSFHYLMDSEAQEDTREAYDDKQVVTEIMARCFIPTLITTTSWESFHFIGHEIRITEAMDCYGAVVWPSALVLCYFLETNAKQYNMVDKNVIEIGAGTGLVSIVASLLGAHVTATDLPELLGNLQYNISRNTKMKSKHLPQVKELSWGVALDTNFPRSSNNFDYILAADVVYAHPFLEELLITFDHLCKETTIILWAMKFRLEKENKFVDRFKELFDLEEISSFPSLNIKLYKAVKKNRRSV
The following text describes a protein:
Function:
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Subcellular Localization:
Cytoplasm.
Sequence:
MQLAIVGVGKLGLSLLTGVIARGVIAPQDIGIIEANAARAQDIAAQTGVQVITPPQLAQVGRIVVSVQPRVFPEVAPWLAQENAGYISTMAGVSAGTIGRRLGTRRVVRVMPNLAATIGRSQTAITGPREAHEAGDIAFAEQLFGAVGQVYELPEHLFNAFTGMSASGPAYVAVVAEALADGGVRMGLPRPLANELAARLLASTGELLLERAHPGLLKDEVASPGGTTIAGLEELEAAGVRGGVMRAVVAATRRGTELGKDQED
The following text describes a protein:
Function:
Plays a role in defense responses triggered by jasmonate, ethylene and chitin.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MQIHKLCFLALFLANAAFAVKFNFDSFDGSNLLFLGDAELGPSSDGVSRSGALSMTRDETPFSHGQGLYINPIQFKSSNTSSPFDFKTSFTFSITPRTKPNSGQGLAFVIVPAADNSGASGGGYLGILNKTNDGKSENNLIFIEFDTFKNNESNDISGNHVGININSMTSLVAEKAGYWVQTLVGKRKVWSFKDVNLSSGERFKAWIEFRSKDSRNTITIAPENVKKPKRPLIQGSRVLNDVLLQNMYAGFAGSMGRAGERHDVWSWSFEN
The following text describes a protein:
Function:
Involved in the avoidance response to the noxious chemicals and repellents such as quinine in ASH and ADL sensory neurons. In response to the noxious chemical quinine, promotes dauer formation induced by pheromones such as the ascaroside ascr#3 in ASH nociceptive neurons.
Subcellular Localization:
Cytoplasm, cytosol. Perikaryon. Nucleus. Cell projection, dendrite. Cell projection, axon.
Sequence:
MFRGKGQQQVSSTDNIKAMMTAAIGNKLEKRLPLVSTIFVVGNDEEEFNIERRTLWQDVLPDLQNLAFQSNFDLEFCDVPLENGELTNSVAEHVLQMWKDNPRSWIVLLLGNRYGNVSVPTSLRKEEYESIRSSIFEENGNVRVFEKAYTINRNGAVEEYRLVPSAIKDKKQLAEIIKALQAGAKAAHEEGSINQVHEQRQNRFFSSPLETFVRSILQVSPCRCLFLLRKFDQLVADPNSPNAFLETNDQNSRKIEDLKNEITLKMNDRVMTHVLRPESTDINYFFNSRDGDKYREKIARQFNEKLKNHLADINPPVRPEPPKSPMVLAANEARTHQEFLENQLALGNLKRDYDKRLDELASVKVNRGVFLIQGTDLCGKTQALCRLYHKISDKDAYKVIFFTNLTYSSNFAHEAWRTICLNICSISNIDPKEVLEHFKLGGILKSLEELVQKADKPVCIFIDDVHLLKFGHLLSQIGRRTETAPDNLSLFMTSSNVAPVNAVFAVTQTVNVDVISENEVVGMVQKMAEKVDKKLTNEQISAIRPLMAAKDGILIAKSFTHEILFNGNSSMKGGMDGRMTRIEKEFGKLAVGNAVKFIAASSHGLTRLEIHDAISADREVLEEMNMSIVYSLLTLDGIIEALGPILRKVIIDDRQIIGIAHSGLISWLRNRYLTSSQDIRSAHLQLSDLFADLLIDNEQSPRHEIAYQSFSQGIKRDNGSPNFRRLRLLWYHCLHSGNLDRLKELSLCHFEYVDYVTRYFGISHLLSLYEECATQILHHDLQVISEQVLVPALVTMARDSEQLAAEVIGRLRFTRHENSHFLNSLVDQAMSWVDLYNRQPLLVPLTCWISPPATKVCRSFTLKDWKPGNTVLTLSANHQYILISGNQSDPGVIYAYHIASEQLIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVWVFSQSTPTMSLTHHTAKVTCAILTSDDQYLITASADSSAKMIKLETGEVMRSFNDHTGSVVSLQLTSNNQFLITGSGDFVVQMWDVTNGKCISRMGGLMAPVSTLAITSNDAFVVVACEDETLKVFSTVGGQELHELMGHEGKVNSLVCAQDDCQLFAATKSKVFCYDIHNGQMIDVLDTAQPFPICSLKISSDNYFLISPCGPKVTIWNVTKRNHDAHDVHADKEGFLTAVALSNDDKYAACGTNNGIVALWDLEVCQCVFTTIQNKGDPITCIRYSVDSQYCISGNQAGCILILDAQNGGVVRELFMHSSEVLSIMSLVHNKMISCDIQGKMVIWELFGDDDTPEMVATGVKPPIFVPPTGRIMVGHCSLSNKEMKIWAFPEEGPPVTRAKLSHSDEITCFATSPKGGNFIATGSRDMSLKIWQIDKGFLTQVLVGHENVVTCCCISFDERLVVSGARDEKIIVWNVQSGDMVCTVNTTAAITSLSMTGDSTVVFSTTEDGWVETWSTTKGRLLSTFNAHRPIKKLINSYESHRMLLLLENCAQLPILCLHNTPAVGVEATRRRSARAQSVSSASNEPVASTSAGEIKKDPILSSNNGGNAQSAPRATAPKPTFDMLERSKSRTSLIEKDRTTTLTQSNAPPPQKSNMCTLL
The following text describes a protein:
Function:
Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLRYAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAMLSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDTSLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT
The following text describes a protein:
Function:
Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signaling cascade downstream of ligand lin-3, plays a role in ovulation by promoting ovulatory gonadal sheath cell contractions. Probably by regulating neuronal transmission in ALA neurons, mediates, independently of let-60/Ras, the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, downstream of lin-3 and upstream of plc-3.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Note=Basolateral and apical membrane of cell junctions in epithelial vulval precursor cells.
Sequence:
MRYPPSIGSILLIIPIFLTFFGNSNAQLWKRCVSPQDCLCSGTTNGISRYGTGNILEDLETMYRGCRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVFHDNALYIHKNDKVHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESCNDKCWGSGDNDCQRVYRSVCPKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDGHLTNETLKNLEGCEQIDGHLIIEHAFTYEQLKVLETVKIVSEYITIVQQNFYDLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKCDTKGFLRNQTSMKCERCSPECETCNGLGELDCLTCRHKTLYNSDFGNRMECVHDCPVSHFPTQKNVCEKCHPTCYDNGCTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDIAQCVSECPKNLPFSNPANGECLDYDIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTNEDGQTELSPSNGDYYNQPNTPSSSSGYYNEPHLKTKKPETSEEAEAVQYENEEVSQKETCL