lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (By similarity).
Subcellular Localization:
[Isoform 1]: Cell membrane; [Isoform 2]: Cytoplasm.
Sequence:
MGPWTLLLLHLPLVVSMLPAPTNVSIVSFNLEHTLTWLPGPETPDNTHFTVQSLRKNSWQLVKGCARLKTRQSCDLTNTFKDPFYHYKARVQAITTTQKSNRSLSMLFYPLTDTLLGPPVVSVSGCGNCPLLQVTPPTSRGLQRSLSPTQLYYRQFTCKVRRTRDGSQFSMWVTSTEKTVIGYLEPGAEYCVTVTPSTSFNPHSVPSEPHCAFTSPTAANTVPVVLSVLCAFSLLVVLLCGIVVYSGRLLCMHKPLPKTLSSVPLCGG
The following text describes a protein:
Function:
Required for the splicing of group IIB introns in chloroplasts. Forms complexes with either CAF1 or CAF2 which, in turn, interact with RNA and confer intron specificity of the splicing particles. Has no peptidyl-tRNA hydrolase activity.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MSLLAAAIPSTSSHFSAPFLPSFRMPRKSLTAPLHRIRRPRPFTVVSSVPDPAAGPVEYTPWLIAGLGNPGNKYYGTRHNVGFEMVDRIAAEEGITMNTIQSKSLLGIGSIGEVPVLVVKPQSYMNYSGEAIGPLAAYYQVPLRHILLIYDDTSLPNGVLRLQKKGGHGRHNGLQNVIEHLDGRREFPRLSIGIGSPPGKMDPRAFLLQKFSSEERVQIDTALEQGVDAVRTLVLKGFSGSTERFNLVQKYKFHRV
The following text describes a protein:
Function:
Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of gsk-3 kinase. Both pathways seem to involve interactions with G-proteins (Probable). Required for the migration and axon formation and guidance of different neuronal cell types including canal-associated neurons (CAN), hermaphrodite-specific neurons (HSN), anterior lateral microtubule neurons (ALM), and the right Q neuroblast (QR) and its descendants. Directs ALM migration through frizzled protein mom-5 and Wnt ligands cwn-1, cwn-2 and egl-20. May act redundantly with mom-5 to direct CAN migration. Plays a role in the organization of head ganglion cells. Probably by acting as a receptor for Wnt ligand cwn-2, plays a role in the positioning of the nerve ring and may in addition positively regulate the neurite outgrowth of RME GABAergic motor neurons along the anterior-posterior axis of the body.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway; The FZ domain is involved in binding with Wnt ligands.
Sequence:
MLLRISVLFLLLGSCGALFGKRQKCEQITIPLCKGIGYNMTSFPNSYGHEKQEEAGLEVHQFYPLVEVGCFQHLKFFLCTMYTPICQENYDKPILPCMELCVEARSKCSPIMAKYGFRWPETLSCEALPKMSDQMSTGNICAAPPDTPKKQHKGHHHKNQNQNQNQNHNYSPDGPEVGISKIDNEVIAGPSECQCTCNQPFQFVASEKSKVGNVTNCAYSCHSPALAESHSLVSNWMAFWSITCCVLASFTFLTFLIETDRFQYPERPIFMLAFCQLMVAVGFMIRYFVGHEEIACDSMRIKGADDNSGSLCFVVFLLTYFFGMAASVWWVILSLTWVLSAASKWSPEAISSFSFHFHVVGWCLPAIQTVLVIVFNAIDGDPITGICYVGNTDLQFQRIFVLFPLLVYFIVGVLFLVIGFCNLWSIRNEVQKQHPSLESAHKITQLMSKIGIFSLLYTIPSLLIICVLFYEQNHRSLWEQSQLCSCSPKQTIGDSSLIISLIKTCCMCILGWTSGFWVCSTKTLSSWKNAICCLGSSRSLPKYQPADILYAKSDMSSSQFYNTSLRHNHLYGGIPDKL
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MFRFLLFAFIFVGLKQDGANAQIYKRVGNKLLPYSTIIVDPLGNGNFTTIKSAIESIPLNNKHWVAIRVKAGTYREKIEIPRDKPYIILKGAGKRKTIVEWDDHAPISQSATFSSMADNVVVKSISFRNTYKNPIKNHTHIAAVAAMISGDKTYFFRVGFFGYQDTLWDNNGRHYYKLCTIQGAIDFIFGAGQSLFERCSISVIGGGYITAQGRTNANDESGFVFKDCHIFGNARAYLGRPWRRYARVLFYKTNMTKIVAPRGWNPWSFDGEEDQITFAEYGNFGPGADTSKRVKWTKKLDLETVENMASLNFINTPEEWINYQPF
The following text describes a protein:
Function:
May be catalytically inactive.
Sequence:
MFGDLFEEEYSTVSNNQYGKGKKLKTKALEPPAPREFTNLSGIRNQGGTCYLNSLLQTLHFTPEFREALFSLGPEELGLFEDKDKPDAKVRIIPLQLQRLFAQLLLLDQEAASTADLTDSFGWTSNEEMRQHDVQELNRILFSALETSLVGTSGHDLIYRLYHGTIVNQIVCKECKNVSERQEDFLDLTVAVKNVSGLEDALWNMYVEEEVFDCDNLYHCGTCDRLVKAAKSAKLRKLPPFLTVSLLRFNFDFVKCERYKETSCYTFPLRINLKPFCEQSELDDLEYIYDLFSVIIHKGGCYGGHYHVYIKDVDHLGNWQFQEEKSKPDVNLKDLQSEEEIDHPLMILKAILLEENNLIPVDQLGQKLLKKIGISWNKKYRKQHGPLRKFLQLHSQIFLLSSDESTVRLLKNSSLQAESDFQRNDQQIFKMLPPESPGLNNSISCPHWFDINDSKVQPIREKDIEQQFQGKESAYMLFYRKSQLQRPPEARANPRYGVPCHLLNEMDAANIELQTKRAECDSANNTFELHLHLGPQYHFFNGALHPVVSQTESVWDLTFDKRKTLGDLRQSIFQLLEFWEGDMVLSVAKLVPAGLHIYQSLGGDELTLCETEIADGEDIFVWNGVEVGGVHIQTGIDCEPLLLNVLHLDTSSDGEKCCQVIESPHVFPANAEVGTVLTALAIPAGVIFINSAGCPGGEGWTAIPKEDMRKTFREQGLRNGSSILIQDSHDDNSLLTKEEKWVTSMNEIDWLHVKNLCQLESEEKQVKISATVNTMVFDIRIKAIKELKLMKELADNSCLRPIDRNGKLLCPVPDSYTLKEAELKMGSSLGLCLGKAPSSSQLFLFFAMGSDVQPGTEMEIVVEETISVRDCLKLMLKKSGLQGDAWHLRKMDWCYEAGEPLCEEDATLKELLICSGDTLLLIEGQLPPLGFLKVPIWWYQLQGPSGHWESHQDQTNCTSSWGRVWRATSSQGASGNEPAQVSLLYLGDIEISEDATLAELKSQAMTLPPFLEFGVPSPAHLRAWTVERKRPGRLLRTDRQPLREYKLGRRIEICLEPLQKGENLGPQDVLLRTQVRIPGERTYAPALDLVWNAAQGGTAGSLRQRVADFYRLPVEKIEIAKYFPEKFEWLPISSWNQQITKRKKKKKQDYLQGAPYYLKDGDTIGVKNLLIDDDDDFSTIRDDTGKEKQKQRALGRRKSQEALHEQSSYILSSAETPARPRAPETSLSIHVGSFR
The following text describes a protein:
Function:
May have a role in maturation, such as during flavor formation or other metabolite production specific to aging tissues.
Subcellular Localization:
Membrane.
Sequence:
MASIWQVLSLVVIVLYILQQLHNKFMKKKKKLPPGPKGFPIIGNLFMIGKNLHQDLYQIAKKHGPIMSMRFGLVPIIVASSPHAAELFLKKHDLVFASRPYNTAAQYIGYNQRNLTFGKYGPYWRNMRKLCTLELLSSLKINSFQAMRKQEIGNFVTFLNRAASNGIEVDISAKLASLSANMACLMVFGKKYMDEEFDERGFKDVIQETLVITATPNIGEFFPFLDRFDLQGFVPRMKKLAKIFDDFFEKIIDEHVQDSKRENKQAKDIVDTMMAIMQSGEAEFEFDRRHIKAVLLDMLIASMDTASTAIDWTFTELLRHPNVMKKLQNELEQVVGTNRMVEESDLEKLDYLDMVVKEGFRLHPVAPLLLPRESIEDCIVDGFDIPKGSRILVNTWAIGRDPEAWPEPEKFKPERFVGSNIDLRGRDFQLLPFGSGRRSCPGLQLGLTIVRLVLAQLVHCFDWELPNGMAPEDLDMTEKFGLVTARAQHLVAIPTYQLHV
The following text describes a protein:
Function:
Essential in controlling the S-M checkpoint that couples mitosis to the completion of DNA replication. It is also required for the response to DNA damage.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MRFKTRISNLYTLTRLVQALDKIGRFCWLRLMPETVNFVIVPDFRMTQVWSVLEVETIFEDYVVQSNADNVINLEVPIDNFYKALRSAANASDSTVRLSKKNNQPLLSLSTTWSGRAFGSNIVTHNIPVRVLSQSYVSVIKEPTAPEPDCHIFLPQLNFLRHVVDKYKSLSDRIIMSANMSGELQLSVNIPSARVSTKWKGLENPELDPSQVEDISRHPSQTRAPEEFVHMRLDSKDLVNMLKISSVAKRVIACFCEGHALVLYVYITDPEDEHTAVLTYYISTYVD
The following text describes a protein:
Function:
Low beta-amylase activity. Interacts poorly with starch or other alpha-1,4-glucan.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAIRLNHSVIPVSVKLGAPTRVSARSSLPFSVGDWRGVSTFSGARPLVLAKVKLRAESTEEDRVPIDDDDDSTDQLVDEEIVHFEERDFAGTACVPVYVMLPLGVIDMNSEVVEPEELLDQLRTLKSVNVDGVMVDCWWGIVESHTPQVYNWSGYKKLFQMIRELGLKIQVVMSFHECGGNVGDDVHIQIPEWVREIGQSNPDIYFTDSAGRRNTECLTWGIDKQRVLRGRTALEVYFDYMRSFRVEFDEFFEEKIIPEIEVGLGPCGELRYPSYPAQFGWKYPGIGEFQCYDKYLMNSLKEAAEVRGHSFWGRGPDNTETYNSTPHGTGFFRDGGDYDSYYGRFFLNWYSRVLIDHGDRVLAMANLAFEGTCIAAKLSGIHWWYKTASHAAELTAGFYNSSNRDGYGPIAAMFKKHDAALNFTCVELRTLDQHEDFPEALADPEGLVWQVLNAAWDASIPVASENALPCYDREGYNKILENAKPLTDPDGRHLSCFTYLRLNPTLMESQNFKEFERFLKRMHGEAVPDLGLAPGTQETNPE
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Sequence:
MTLLLARAFAPARSQLGKALLRSRFSTTAAVCSSTSSATMALKVGDTIPDATVSETDLYTTLKLRELFAGKKGILFGIPGAFTPGCHKTHLPGYVQRAEELKGKGIDVIACMGVNDPFVMAGWGETVGATGKVRMLADKDASASKALGVYWEGSEAIFGSGRCKRFSMLIEDNIIKVINVEPDNGGPSCSLVEPL
The following text describes a protein:
Function:
Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
Sequence:
METKQSMDYIIKGPGGTTKPIAPKLITVNPLNIIIESNSGQIDKTLELKNIYPCRIAFRVRTNGPTRYTVCPSKGFLSNGEKVAIQITLIDGTKYQSNHQFIVQAMPSPGDFADRKFIWKQPNFLGIFTNTRVKTMRPAQSLPKSNPKSPAKVSTPTDSGMSSPVASSESLVTPSVPSWSKSPSSPIDHGKFAENINDLSVQVKKAIDEKNTRTSEMVSVVNQIKAVEVDLDRQAQLVNELSERVKRGEIQYSNLVMHERSLRVELGRLKNNEAESIGQ
The following text describes a protein:
Function:
Mediates spermatid-Sertoli adhesion during spermatogenesis.
Subcellular Localization:
Golgi apparatus membrane; Single-pass membrane protein.
Sequence:
MMAEHPPLLDTAQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQSPEFHPGGHTVIHRSPHPPLPGFIPVPTMMPPPPRHMYSPVTGAGDMATQYMPQYQSSQVYADVDAHSTHGRSNFRDERSTKTYERLQKKLKDRQGTQKDKMSSPPPSPQKCPSPISEHNGLIKGQNTSGVNTGSARNRSGRGRGCTQVDQEIEEKDEETKAFEAFLSNIVRPVASDIQARTVLLTWSPPSSFVNGEVTETTVPEFFNYEILVSSTGKEGKYRSVYVGEETSVTLNDLKPATDYHAKVQAESNSIKGIPSEAESFTTLSCEPDTPNAPRIANRTKNSLTLQWKAPSDNGSKIQSFILEWDEGKGSGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAKNDYGVSDFSEEVLYYTSGCAPSVPASPVLTKAGVTWLSLQWTKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSSPSEVVEFSTCPDKPGVPAKPSVKGKVHSHGFKITWDPPRDNGGAPINKYVVEMAEGSNGSKWDMIYSGATREHLCDRLTPGCYYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPQVDGGSPISCYAVEMTPADKDEPRDVYQGSEVECTVSSLLPGKTYSFRLRAANRIGFGPFSEKYDITTAPGPPDQCRPPQVTCRSATCAQVNWEIPLSNGTDITEYRLEWGGVEGSMQICYCGPGLSCELKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPAIVTCLQEIRDDDIEYPHYSPSTCLAISWEEPYDHGSEILAYSIDLGDKQPLTVGKVTSYVINSLQPDTTYRIRIQALNSLGAGPFSHTIKLKTKPLPPDPPRLECVAFNHQNLKLKWGEGTPKTLATDAVQYHLQMEDKNGRFVSLYRGPCHTYKVQRLSESTSYKFCIQACNEAGEGPLSQEYVFTTPKSVPAALKAPKIEKINDHICEITWEYLQPMKGDPVIYNLQVMVGKDSEFKQIYRGPDTSFRYSSLQLNCEYRFRVCAIRQCQDPAGHQDLVGPYSTTVFFISQRTEPLASSNRDTVDSARTRRTLSDEQCAAVILVLFAFFSILIAFIIQYFVIK
The following text describes a protein:
Function:
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
Domain:
Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.
Sequence:
MFAAHLEFFAAHQCAEAHWLPDTGLDILERIEIGRDFAYPSIKDRLPVILTKIVDVLYRDKCFVRGQFGEAGIEELKDFIGKISRLRSELQTDKPFTLLEEDCPDTEAWNQRIQIPNLVENPIECTDPSPLSVPLTSPTPQASWFTSSWLLAECYCYRKIASISLTSNYLRNLDPFKGQKQLALIESLDAIVSLSSFLLSNINCTLNDSTTSEALFKSLLYTSVWGNKCDLSISSGEANNQLSNVLMQLDLLKSYVLQDDVQKIFDYLVLLKTNNAVVNNNPHISYMPKTDMNRIDFVLDNAGFELFSDLCLAEYFSAIFGVQKIYFHAKIIPWFVSDVTNDDWYWSFEWMKQSGSAELLKLANLWEARIEAGQWIFTTHHFWTLPDTFDLMNSVAPDLYQQLSESTLVIFKGDLNYRKVTGDRKWDPTVCFGKVLNGFHPSSFCCLRTLKSDTLVGVTHEAVQRAKEERADWMISGQFAVVQSILPYP
The following text describes a protein:
Function:
Essential component of the MRP ribonucleoprotein endoribonuclease that cleaves mitochondrial primer RNA sequences.
Miscellaneous:
MISCELLANEOUS: Present with 172 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MNKDQAEKYQERSLRQKYNLLHVLPTLNSRALSGLYYKNFHNSVKRYQIMLPEQLKSGKFCSHCGCVYVPNFNASLQLTTNTEQGDSDELGGESMEGPKKCIQVNCLNCEKSKLFEWKSEFVVPTFGQDVSPMINSTSSGKVSYAVKKPQKSKTSTGKERSKKRKLNSLTNLLSKRNQEKKMEKKKSSSLSLESFMKS
The following text describes a protein:
Function:
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Seems involved in the function of the photosystem I in low light conditions, when other LHCA proteins are less abundant. Required, together with LHCA6, for the formation of a full-size NAD(P)H dehydrogenase-photosystem I supercomplex (NDH-PSI) that triggers cyclic and chlororespiratory electron transport in chloroplast thylakoids, especially under stress conditions (e.g. increased light intensity) (Probable).
Miscellaneous:
MISCELLANEOUS: Light emission at 684 nm upon excitation at 410 and 470 nm.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Domain:
The N-terminus of the protein extends into the stroma where it is involved with adhesion of granal membranes and post-translational modifications; both are believed to mediate the distribution of excitation energy between photosystems I and II.
Sequence:
MAVVLRGGITGGFLHHRRDASSVITRRISSVKAAGGGINPTVAVERATWLPGLNPPPYLDGNLAGDYGFDPLGLGEDPESLKWYVQAELVHSRFAMLGVAGILFTDLLRTTGIRNLPVWYEAGAVKFDFASTKTLIVVQFLLMGFAETKRYMDFVSPGSQAKEGSFFFGLEAALEGLEPGYPGGPLLNPLGLAKDVQNAHDWKLKEIKNGRLAMMAMLGFFVQASVTHTGPIDNLVEHLSNPWHKTIIQTLFTSTS
The following text describes a protein:
Function:
May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.
Subcellular Localization:
Cytoplasm. Membrane. Note=May become cross-linked to membrane proteins by transglutaminase.
Sequence:
MSNVTLRKMSPTGNEMKSTTQGTTRKQQDFHEVNKRRTFLQDNSWIKKRPEEEKDENYGRVVLNRHNSHDALDRKVNERDVPKATISRYSSDDTLDRISDRNDAAKTYKANTLDNQLTNRSMSMFRSLEVTKLQPGGSLNANTSNTIASTSATTPVKKKRQSWFPPPPPGYNASSSTGTRRREPGVHPPIPPKPSSPVSSPNQLRQDNRQIHPPKPGVYTETNRSAERNIRSQDLDNIVKVATSLQRSDKGEELDNLIKMNKSLNRNQGLDSLFRANPKVEEREKRAKSLESLIYMSTRTDKDGKGIQSLGSPIKVNQRTDKNEKGRQNLESVAKVNARMNKTSRRSEDLDNATEVNPKGHENTTGKKDLDGLIKVDPETNKNITRGQSLDNLIKVTPEVKRSNQGSKDLNNFIKVYPGTEKSTEGGQSLDSLIKVTPERNRTNQGNQDLENLIKVIPSANKSSEQGLDEHINVSPKAVKNTDGKQDLDKLIKVNPEIFTNNQRNQDLANLIKVNPAVIRNNQSQDLDNLIKVKPSALRNTNRDQNLENLIEVNSHVSENKNGSSNTGAKQAGPQDTVVYTRTYVENSKSPKDGYQENISGKYIQTVYSTSDRSVIERDMCTYCRKPLGVETKMILDELQICCHSTCFKCEICKQPLENLQAGDSIWIYRQTIHCEPCYSKIMAKWIP
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MVAVDRATLSKATALLGAQGVCWKSRLSLPPDPASRQPGMAAAPPDGQEKVIAAAQHIVKSLASSKNAADDMIRILSGFDNRLSLMSDLFPPPPGAAAADSILEEDEGTSQGDGHEEDEPDPDDDAAARAEEEWDAAAEVIERWESPDAGDRMVFGSREDAEEYLAAAACLAGAPGPRAEAALQAAMARLEDEFRHLLIRGGSPLAAEDLQASLLRRLSLTVPSFNSSAVDLDCPSFAIHAGEGGDESGGRSSVSDDEISPYLIAPDTVGALRDIADVMLRAGYAPELCQVYGEVRRDTLMECLAVLGVDKMSLEEVQRVEWGVLDGKMKKWIQALKVVIRGLLAEERRICNQILAADPNAEEECFTEAAKGCVLQLLNFGDAIAIGKRSSEKLFRILGMYEALAEVLPELEGLFSGEAKDFIKEEAVGILVRLGDAVRGTIAEFASAIQGETSRRPLPGGEIHPLTRYVMNYVRLLADYNASLNQLLEYWDTELNGGDNPNMTPLGHCVLMLITHLQSKIDEKSRLYEDEALQNIFLMNNLLYIVQKVKDSELKTLLGDNWIRKRRGQIRQYSTGYLRSSWAKVLACLRDDGLPQTMGSSSALKAALKDRFKNFNLAFEDLYRTQTSWRVVDPQLREELKISISEKVLPAYRSFVGRFRGQLEGGRGSARYIKYNPEDLENQVSDFFEGKKPNA
The following text describes a protein:
Function:
Plays an essential role virus particle assembly and budding. Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD6IP/ALIX, NEDD4 or TGS101. The interaction with host E3 ubiquitin ligase SMURF2 also facilitates virus budding. May play a role in immune cell dysfunction by being packaged into exosomes that can decrease the viability of recipient cells (via RNAi suppression and exosome-bystander apoptosis).
Miscellaneous:
MISCELLANEOUS: Most abundant protein in the virion.
Subcellular Localization:
Host cytoplasm. Host cell membrane. Virion membrane; Peripheral membrane protein. Host late endosome membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Host endomembrane system; Peripheral membrane protein. Secreted, extracellular exosome. Note=In virion, localizes on the inner side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and probably also in multivesicular bodies. These VP40-enriched membrane clusters are then redistributed to the plasma membrane where budding takes place.
Domain:
Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. VP40 contains two overlapping L domains: a PTAP/PSAP motif, which interacts with the UEV domain of TSG101 and a PPXY motif which interacts with the WW domain 3 of NEDD4 E3 ubiquitin ligase and the three WW domains of SMURF2 E3 ubiquitin ligase.
Sequence:
MRRVILPTAPPEYMEAIYPVRSNSTIARGGNSNTGFLTPESVNGDTPSNPLRPIADDTIDHASHTPGSVSSAFILEAMVNVISGPKVLMKQIPIWLPLGVADQKTYSFDSTTAAIMLASYTITHFGKATNPLVRVNRLGPGIPDHPLRLLRIGNQAFLQEFVLPPVQLPQYFTFDLTALKLITQPLPAATWTDDTPTGSNGALRPGISFHPKLRPILLPNKSGKKGNSADLTSPEKIQAIMTSLQDFKIVPIDPTKNIMGIEVPETLVHKLTGKKVTSKNGQPIIPVLLPKYIGLDPVAPGDLTMVITQDCDTCHSPASLPAVIEK
The following text describes a protein:
Function:
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
Subcellular Localization:
Cytoplasm.
Sequence:
MRIFITSTNTDVGKTYVTKHLYHALKTRGHRVCIFKPFQTEERQDGTFPDLEVFKNECDLSYDITSLYTFKQPVSPHLAFKMTDQIFLNKQRVLDKVKVLDKEFDFILIEGAGGIAVPIYEGTDDFYMTKDLINDCADCVISVLPSKLGAISDAIVHQDYVNQNVSASNFLIMNRYTDSYIEKDNQMTIGKLTNKTVYTFEEHATYENFSEAFLKQLIGVKNELHTTT
The following text describes a protein:
Function:
Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPLPWLPSNSCPGSSSPSRTAATARRTISGGTGAGSQGADLGGGGAMTTLRAFTCDDLFRFNNINLDPLTETVALAAFLSQIAARAKSIKSMFLAGGSTEGKYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKRLGYSVYRTVIEYYSASNGEPDEDAYDMRKALSRDTEKKSIIPLPHPVRPEDIE
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MTLLTFRDVAIEFSLEEWKCLDPAQQNLYRDVMLENYRNLFSIGLTVSKPGLITCLEQRKEPWNVKRQEAVDGHPEMGFHHATQACLKLLGSSDLPASASQSAEITGVNHCAQPALKVSVDKFTALCSPGVLQTLKWFLEFRCIFSLAMSSHVTQDLLPEQGIQDAFPKSILRGYGNCGLDNLHLRKDWESLNECKLQKDYNELNQCSSTTHSKIFQCNKYVKIFNNFSNLHRHNISNTGEKPFKCQECGKSFQMFSFLTEHQKIHTGKKLQKCGECGKTFIQCSHFTEHENIDTGEKPYRCQECDKVFKTCSVLTKNRIYAGGEHYKCEEFGKVFNQYSHLTEHERGTEEKPCKYEECSSVFISCSSLSNQQLILAGEKLSKCETWYKGFNHSPNPSKHQRNEIGGKPFKCEECDSIFKWFSDLTKHKRIHTGEKPYKCEECGKAYTQSSHLSEHRRIHTGEKPYQCEECGKVFRTCSSLSNHKRTHSEEKPYTCEECGNIFKQLSDLTKHKKTHTGEKPYKCDECGKNFTQSSNLIVHKRIHTGEKPYKCEECGRVFMWFSDITKHKKTHTGEKPYKCDECGKNFTQSSNLIVHKRIHTGEKPYKCEKCGKAFTQFSHLTVHESIHT
The following text describes a protein:
Function:
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular Localization:
Cell membrane.
Sequence:
MLSPDLPDSAWNTRLLCRVMLCLLGAGSVAAGVIQSPRHLIKEKRETATLKCYPIPRHDTVYWYQQGPGQDPQFLISFYEKMQSDKGSIPDRFSAQQFSDYHSELNMSSLELGDSALYFCASSL
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Sequence:
MVDPLKIFWVLTNSTYLVTKFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNESTNIRYQITGGNIGNAFAVQNTTGVIYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDETNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGSKSVLVYNYQGQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQEHQRFKLDTDTGILTMRAGTRRGRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRNKLAELLYTDRDNVDVFSVQLKEGSPYPLTDVHFAARSATQQPYFKAVRLNGVVQMHREEIEKDVGLNITMVNINECLHEGKGKCGSNSCTSKVELGKKPYTVSVNRTALVGVRLDISAQCVCRARNFTHQDHNCRTHLCYNGGRCVETRNGPKCVACPVGYNGPRCQQSTRSFRGNGWAWYPPLQLCQESHLSLEFITRVADGLILYNGPIVPPKPEETVISDFIALELEQGYPRLLIDFGSGTLELRVKTKKTLDDGVWHRLDIFWDTENVRMVVDFCRTALVSEMEDGTPPEFDDNACQARGQIPPFAESLNLNQPLQLGGLYRQHFDQTLYNWQYAFSSKGFDGCIRNVIHNSEHYDLAFPALARNSFPACPQTDEVCLKTEHTARCWEHGNCVASLVQAKCHCQPGWMGPGCNVPTIPTTFKAQSYVKFALSFEPDRFSTQLQLRFRTREQGGELFRVSDQHHREYAILELRRGHLQFRYNLNSMRNEEQLLTLTAIAVNDGQWHVIRISRYGSAALMELDGGESRRYNESFHFTGHQWLTIDKQEGVYAGGKAEYTGIKTFEVQSDFQRSCLDDIRLDGKHLPLPPAMNGTQWGQATMARNLERNCPSNRPCSNVICPDPFDCVDLWNEYECTCSEGRIMSSDTKGCVDRNECLDLPCLNGATCINLEPRLRYRCICPEGYWGENCELVQEGQRLKLSMGALGAIFVCLIIILILALIFVLYSRKRKTTKKKKRSGPEKDVRETVISYEDEGGGEDDMTAFDITPLQIPISAQGGPPDIAACKMPIIYPVMTLLPPGQELNVAYLMEERKQRIDKDNNAPPFDDLRNFTFEGSGSIAESLSSLASGTDDENQDFNYLQNWGPRFNALAAMYVHDKAKASSQLPSDGGGGSGDGPGPGASSSSPLGGGGTGGGSGIPGNVLAVVATGSGAGPGGGGGSSGLMPLPEVDKVVL