lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MMSVFILGSYAKALVMTTDRIPLAGETLIGYDFRQTWGGKGSDMAVQAVRLGAEVAYAGVVGDDTFGHEFVGLMQEEGVNIDALTISGELPTGAGLIVKDKEARNVIVVDMGANKLFTPALVDSALSQLKQSNVVLTQLEIPLETARYGLQRAKEFGKITILNPAPARDLRGLDLSAIDYLTPNETEARVALGLPPDDPRSNREIANLLLETGCQYVVMTLGESGSAVFGRNDTQEIPPCIIDVVDSNGAGDSFNAALAVALDEGLPISEAVLFANATAALCCMDWETVPSYRYREDVDAFMRSITVKEE
The following text describes a protein:
Function:
Microtubule-associated protein that may be involved in the maturation of cell plates and proper insertion of cross-walls after cytokinesis.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton, phragmoplast. Note=During interphase, binds cortical microtubules. In M-phase, locates to the preprophase band. During cytokinesis, binds the phragmoplast but not the forming cell plate at the midline, and at a later stage the cortical division site. After cell-plate insertion, enters the new cross-wall.
Sequence:
MEEVAAKVEEETVETNVDAVKEDNATIANESRSPESVSAVSVVSNRAASTKKKPVISSNLIKPTASSSLRVSGTTPVTIRRNSTGGVTENLAGTSKVLPKQVSTTASRTDPVRRSLPELRKSSVSSLSAKTVSKPSLSESKKSVPVSPGSRSLTKSTGFSLSKPESSARPAMSVSVSSKRAPSSSVDSSGSRTSSGRLHSTLTSGRTVSKVSSPSAGSSPSVSSSIRSKSFSSPLDRTSNFSGRKKTSTPESRDSRLIILPKVEVKAGDDMRLDLRGHRIRSLTSGGLHLSPNLEFVYLRDNLLSTLEGIEILNRVKVLDLSFNDFKGPGFEPLENCKMLQQLYLAGNQITSLASLPQLPNLEFLSVAQNKLKSLAMASQPRLQVLAASKNKITTLKDFPYLPVLEHLRVEENPLLKISHLEAASILLVGPTLKKFNDRDLSREEVAIAKRYPPQTALCLREGWEFCKSDLAAESTFRFLVERWKDTLPSGYLIKEAHVDRPSEEAPCQCHFGLFQESPTATDQELALKFQWSVADRSLSNFVPILNATKEVYWPKREDIGKILKIECTPVMAETEYPSIFAISSPVQRGKGIPKVVSLELNGELVEGNIIKGQAVVAWCGGTPGKCITSWLRRKWNGSPVVIDGAEDEEYMLSLDDVGSSMVFMYTPVTEGGARGEPQYKYTEFVKAAPPSVSNVRITGDAVEGCVLKGVGDYFGGKEGPSKFEWLRKNKETGELSLISAGTSEYTLTQEDVGTHVTFVYIPANFEGLEGEPVSTSSSVVKPAPPKVTDAKIVGDLRENSKVTVTGTVTGGTEGSSRVQWFKSSCSILEGDNSLEELSTSKVAKSFRIPLGAVGYYIVAKYTPMTPDGECGEPVYVLSERAVETLPPSLNFLSITGDNIEGGILTASYGYIGGHEGKSKYEWHYHKAENDLPGALIPEASGLLQYTITKEAIGKFISFQCIPVRDDGIVGEPRSCMSQERVRPGNPSTVSLHVVGALVEGTMLSAEKEYWGGEEGASVFRWFRTNSDGTPCEIKGATTSSYLLSVGDIGYFISVSYEPVRNDRARGPTAISEIAGPIVAGHPNCQSLEFLGSMIEGQRLSFVASYTGGMKGNCYLEWVRVKNNGVKEILSSDEFLDLSLDDVGESIELIYTPVREDGIEGSPRSIRTDGIAPANPMGLELLIPDCCEKQEVVPHKTYFGGHEGVGEYIWYRTKVKLHGSALTEISYAGEEVVVCCRTLKYTPSLEDVGAYLVLYWIPTRVDGRSGKPVVVITNSPVAPADPEVSNVRVKKLFSDAYSGEGEYFGGHEGPSLFSWYRENDGTIDLIDGANSKTYEVTESDYNCRILFGYTPVRSDSVVGELKMSEPTEIILPEVPKVDMLAFTGKAVQGDVLTAVQVIPKTEIQQLVWSKYKGDIQYQWFRSPESGDKISYEALSSEISCSYKVRFEDIGRCLKCECVVHDVFGRSSELAYAETDPISPGFPRIEKLEIEGQGFHTNLYAVRGNYFGGKEGKSKIQWLRSMVGSPDLISIPGETGRMYEANVDDVGYRLVVVYTPIREDGVQGHPVSASTEPVAVEPDILKEVRQKLETGLVKFEVLCDKDPYPKKIVGEGNLERRMLEMNRKRIKVVKPGSKTSFATTEVRGSYGPPFHVETFRNDQRRLRIVVDSENEVDIVVQSRHLRDVIVLVIRGFAQRFNSTSLNSLLKIDT
The following text describes a protein:
Function:
Component of the kinetochore which plays a role in stabilizing microtubules and so allowing accurate chromosome segregation. Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Associates with telomeric and mating-type region heterochromatin.
Sequence:
MVSVKPLPDIDSNEGETDADVYEVEDILADRVNKNGINEYYIKWAGYDWYDNTWEPEQNLFGAEKVLKKWKKRKKLIAKGLLEPFDAEDNEAKKMKREKEILRQQRQKRKSELTQLSQKVKEKFKKMRKKPARRIVTIANDEEEEDDQTMDEDAFERKSMQGELKERNLTDKTSTLSTSFGETSPDVNPFYLSEWPTVTDSILLSKSLSSDAIPLKNGEIKSTMLMPSDSDNSVPGIQNSNNLENTGAFVENANSPQSNTPLSTFRHSSPLSLSPVITSDNDVANSLFFSNSTPLPSSLKIKKEAPKLETHTILVSDNSGSLTKQDILSYFAFIKGNIEVFFLKSPKKDKVCNMAYIQFDSIEQAKLAYDKGHPSWHVTLVKGKISTDMEECKVSKSILKTTPSKKANARSVSFTQTTTDTLSESEKFASNVDLDENFDFNVNVTNEDAKQLKKSVIGSSWTTVNNDWNSVSKSDQTFENDGASKVVPAGNITLNSDNSLHHSISESEDLSSASTLSDYFRFVLRVGKSLYYAGELSFDISKLKAETEHQQLLRSLVSCKQVDVLRFVTSQYLEVFGTCLTKVLSGSLCIRSDVDMTHFKNILNRGNGAGIVLGSNYTLLLFTEDNNALMNLYDCQGQSNSPFWMVIFEPLESILVEWSAKNLRPKKPYHKSQSYLSYLLQLGHIDLHKIGAFQATQILIVSKQPSPEAEELEDTFREAAIPTFRGLEIPESLFLSQNVFVFLNVSLEDDFDQLQFLTLAKRKSCKFFLFGLSLPLKSPNDSHVGTDFKKNNEPLDKLTYSQYLRPMFPKGGVVSVTLSALIKTPRLLELISPFLEIKKDSWILILPPSIVDMVKSYFVTNNPDKSLLEIQNLLNTLQRYLTNPALKNVTLYQDWDIVIDDSADVSLASTLQLYQKKNYDKYRRFVLIHELKNELTPVNGLDIVDYDEFKETFMRAIGLK
The following text describes a protein:
Function:
Single-stranded DNA-dependent ATP-dependent helicase.
Subcellular Localization:
Nucleus.
Sequence:
MPPKKVSPGITVILIDAGSNMSVKDTETGKSAFENAINAADWIVSRKLFSKDPELFSVMAYNLDPKEYKTEVGGQTFNGVQCQNEKFTPASFDHLKFITKELQQNTEMIDPNFFKGVLGAVAVLKDQIESYPNPSGITLIVLTNGLNENIRQENFDLLVEAVSESNADLMIIGIDENPEYPASRVAELAETLEGRTYTFQNVAKMLSTFQARQKSERKYNKMWDIAPGIHLPVIFALKSEKSTALLKFKNADSEGNEMVRLEQMHVETDEVAPKDEFKSPVLEEKPKFQKNFKPVENIKTMHGYNFGKSVIMMDPEYLKEKYNDHNFNEGQTGGVLKLIQFTKRANILDSYLLDASAKTVLPALNSPKSGATKATVSLIEAMLSLRVAAICRYTFHAKSHVQLIALLPHQDEETGVFYLRSVKLPFSDDMRTLKFPKFSFDEEDEDLNKPTVAQLSAVDDLIDCMQLQEDEISSLVEGGMSDPKLQMQCHFLKSLVLHPNDTFENHSNRTNQILDQIMAPKRRVEAEHPEIFQKLGREFNLQPIQKTKRERVTVEPEDLQTMISEWTEKKQNMTQPDEVDDGASQKKKKKPNAKKLTRKEEVQMDIMEDGGASRVCSKILEMISNTCKFQPNGAVTEFFTLLVNELNVIRSVFVENSKCDEFNELLKKLKDEEDFEPFAEVLSEEKSCNPIDSSEVSMSEVSVANAAEFWEED
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSEELENKFLELCAKYPAGLNQQMMEMGLGHKMEDVAKVINNLLKQGRLLIHQNPDETTSYREVNPEDQMKFRGLGAEDFLIYQLIETSGNNGAWTRELKQQSGYQQVQITKILKILENRKLIKAVKSIQSGRKKVYMLYNMEPSRDVTGGTLYGGDQSYDHQYIQIMKMHIKTFVENKGAVDLSDIMTYLRKVAEEATSQSLGPEDIQALVNTVIYDGDIEEMRDTRMGALMGRRSGILYKPTKTSIPVNNFCNMPCGNCPVFEICSDDGIISPKKCVYFQQFLDQTDDLDF
The following text describes a protein:
Function:
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Subcellular Localization:
Cytoplasm.
Sequence:
MVKFKSTSDVMKIIKNKDQIRNFGVIAHVDHGKTTMSDSLLAYSGIIAPSAAGKALAMDFDKEEQQRGITIYQANVTLLFQQKDKEYVINMIDTPGHVDFSGRVIRSLRAIDGAVVVCDAVEGIMTQTETVTRMALEERVKPVLFINKVDRLIKELRLTPEKMQAQLAEVVSNFNQLIDTYAEPEYKEKWKVSIQDASVTFGSAKDRWAINVDLMKERGITFKDVIDAYENEKVADLVEKAPLADAVLGMVVKHHPAPAEAVKYRIPQIWKGDLDSDVGKALLSCSDDGPTIMMIVNMVLDPAAGPVAIGRLFSGTIKDGQTIQIIDEKREGRVQSVNFFMGNQREQVGELGAGNIPALLGLTEARAGNTLSTVKDIPMFEGVKYVSEPVVQVAIEPKHPKDLPKLVEVLKQLTIEDPNLVVKIDEESGETIVAGMGVLHLDVATHRIQDAKVEIVTSEPLINYRETVKAGCEPIMAKSPNRHNKIFMKVEPLEPEIATMLRTGEISDMKDKKVVSDLLKGAGWDTDTIKRVMKFDSRGNVLINGTKGVQFVQESTDSINSGFDEVMKEGPLCKEQMRDCKFTFTHFVPHEDTAHRGLSQLGPASRRACMGALLTAGTAVLEPTLAIEVRVPTDLVGNVATVLSGKRGKVLDMAQKGASSIVTGEIPASETFTLSEEMRGQTAGRATWNTSFKAWTEVPKSMLSAAVSDIRKRKGLAPDPPGANEFIDKE
The following text describes a protein:
Function:
Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit; Required for proper chromosome segregation during mitosis and error-free mitotic progression.
Subcellular Localization:
Chromosome. Nucleus, nucleolus.
Sequence:
MGTVSSAYRQTTSAAEASSEEESLAQNTEMPSSEIDSKPSQDTNVATDSLNMKSLEPVSSVANIRRVPASGRVWKSIQTKAHFQKRSNGEKMGWEKRQKDRKQLDILKTMKAEMEQRHKEEKDLKKKNAEERRKRKEENEKKADVVQQISAAKVRRLKKKQLRSQNIRKK
The following text describes a protein:
Function:
GTPase-activating protein for p21-rac.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQEAPRPKRIICPGEVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFYDGKHFVGEKRFESIHDLVTDGLITLYIETKASEYISKMTTNPIYEHIGYATLLREKVSRRLSRSKNESRKTNVTNEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANIYPDINIITGALKLYFRDLPIPVITYDTYSKFIEVAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRTGRCLGSHPAARLRATGGKAGADAGDHREGGAATAEALAHPRRPGPLAGGPWPRAARAARAPGGNR
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. In addition, is involved in the utilization of D-sedoheptulose 7-phosphate, an intermediate of the pentose phosphate pathway, via the sedoheptulose bisphosphate bypass pathway. Catalyzes the phosphorylation of D-sedoheptulose 7-phosphate to D-sedoheptulose 1,7-bisphosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MIKKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENIRAVAIENLKKRGIDALVVIGGDGSYMGAMRLTEMGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDTSSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIAKGKKHAIVAITEHMCDVDELAHFIEKETGRETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGRCVGIQNEQLVHHDIIDAIENMKRPFKGDWLDCAKKLY
The following text describes a protein:
Function:
Probably participates in deamination of adenosine-34 to inosine in many tRNAs.
Sequence:
MAQSEEAYDEKWMKEAVNMAKQALGRGEVPVGCLLVYEDQIIGTGGNAANETKNATRHAEILALEEAMRWCDDKQLERGELFSQTKLFVTVEPCIMCAGALRIMGIKKVVYGCRNERFGGCGSILSVNSDELPSIGEPFECKAGLYADTAVQLLQEFYKGQNPNAPNPKIKASGMKDEGPQLQCPGDTDTKDQVETATPVK
The following text describes a protein:
Function:
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
Sequence:
MPHNILAIPALNDNYIWTIVHPQKQAAVIIDPGEAKPVLDFLKQQKLNLAAILVTHHHWDHTNGIQGILQKHPAPVYGSVESAIPFCDHPIVDGQTFSIPYAELTFNVLAIPGHTLDHVAYYADQWVYTGDTLFAGGCGRIFEGSPDQFYHSLQKLASLGPTTRVYCGHEYTVKNLEFAETVEPDNPKLKQRIVETGQKASQNLPTLPSTLQVELDTNPFLRCHQKNIQRRVQEYCGYPLADTVAVFSALRRWKDEF
The following text describes a protein:
Function:
Probable member of the two-component regulatory system YkoH/YkoG.
Subcellular Localization:
Cytoplasm.
Sequence:
MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAAEGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYVTKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPREFDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHTIRGVGYAIKG
The following text describes a protein:
Function:
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
Sequence:
MKVRLFEIFTSVEGEGILYGTKTLFVRLAGCPFTCFYCDTKESLPLDSGTEYSIEDANQLIDSNLKNQTYKVNFTGGDPLIQHQAVALLAKHIQEKKIPTYLESSCFDIDRFNHVLPFIDIVKIEFKTKDSDFVDSQHYEKLIGHTMKCLESSVSAKKITYIKVVVSSKTKPDDFTQLVNQIFDIVSKDDIDGFIIQPTYGVAEPSLDLLLSLYDIVFPHYNEVKVVPQLHKFIGAP
The following text describes a protein:
Function:
DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MKRMFSEVEMCRDVAIPAKQLKKGHSPPHQQILTRLLQDLLHEKACREHGFYLAITALKSIGNINSTTDDDNPQADDVLTFPVSFTCRTFLPARGNIMVGTVMKVLFNGLNGGAAPAVLISSGPLRYAYLSYLKMPDYHFVPPNSEEEEEPCFQKDDLTKIAVGVVVRFVVLGRRFKVSPEKRRTDVYVLASVEGDDTLGPVSLTGCDRPYM
The following text describes a protein:
Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Subcellular Localization:
Nucleus.
Sequence:
MSPISPSQFVSRQDQPIVIDDNDEDDNGVASTSVRHPPAQSPTTSLRGITPAMSVATTSTSSINPADERNSASGPPSSLDRYRTGYVYSADMMLHVNPIDPDHPERPLRIFKIFMKFKESNLFARMKRVPIREVAEEEVKLVHDHGIWEGVQRLAFYHPDVLKEQVQLLETNSSLYINEHSAYAARLSCGGAIELVNAVAAGQIQNGFAIVRPPGHHAEPQKSMGFCFFNNVAVATRVVLRRHAHIKKVLILDWDVHHGNGTQRAFEYDDNVLYISLHRYDEDGSFYPGSTYGNFDSAGTGPGEGRSVNIPWLSQGMGDADYLYAFNHLVMPIAHEFQPDLVIISAGFDAADGDPIGLNRVSPGGFAQMTHLLTSLSQGKVAVVLEGGYNPEAVASSALAVVDVLLSRNTAEPLETVASTSAAATVHCVRRFHQKWWKSLRSSPLEADEADIAVAPIDVGRILAAFRTETVAQQYDLLEVPLQHTPHSRFGGQVLVSDRILDKFSTILFFVHDMGNWRSERPQPSMRAEQMALQLVDASRGIMDYARARGFGLVDVNINREFSTTRLKLPPGVREPPRHDEEASAAAAFIWDNVVSLATGPVGPPKIVMVGFGSGCRALTSIIDERNVELCVHAIVNVVGYEDMPHLALAAGVEKKKWYYRRTMVLAPADHRHLVERADAAPLKRFGRITPVHDTAAINILAHKTADIQTFIDKKLQVAKKSTSTTL
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds directly to 7SL RNA. Mediates binding of SRP54 to the SRP complex.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MDVGGRDGGSSIKKWDIIYPVYLNSKKTVAEGRRIAAAKACADPTCNEILDSCAYLKIPCKIEQDKAYPRDFFQRGRVRVQLKNEAGSPVNPAIRTSDLSVGELRRCGF
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.
Subcellular Localization:
Nucleus.
Sequence:
MSAVSKNGRAYRQRKVGIKTVMPIYRENEIPDFDEETSMQRTVPQVESGVEKEEEEERHLQLVIHAAHEAIVQGAEKTAIIPTRPAVPVGMLPKFYKKDYSVPTTWLRFSMTVEECAAPMYCMDERDVSQWIELRKQHQELERFSDDDYELCMQTFEDAISEKQPYLSIDKAQILSRDEILPFFDEKGVSSLKPLATELYGYWRSRKLERSGLSVMPSIQIGDDKDKDDPYICFRRREVRQPRKTRRSDLQSLERLRKLRIDMETSLFLLDQVLQRENKKLELLQTDRSVFQHRCIMKRLKRTLSIKDSDVGLFSPKRRPPVIDQKPSKTHLAPSVSHAEGEFASEGSVEAGVAQKQYRASTATGAAAAYRPIPTQIHDAHPVRYLEDVQADAYTHFQIRLQQEIAKRAQSSLKWVDLLENPGTALPFALPETFYRNVEFFPTNGKTGLSQLTASPSDSAPSPSSEDTASEDGQQLYLSGRRRDSTTSASEVLYRYSTHCTPRNAVTVRRRMGRGGRIILDRTYALPMHQPRSTTSRLKDRWLFHTPFDADDTIILDDESDASVLYRSQLLRLHADTAAITENAVK
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
Sequence:
MRPPAPPPPSPLPSDYKSRDAPRLRGGTGLPASPPDYKSRDAPRKDGPSGLPPGLQVPRCSAERRSFRPPPRTTSPEMPRGSAAGRAFRPPPPAGLQVPRCSAERRSFRPPPPPPGLQIPRCPAARRQDGPPGLQVPRCPAGRRRGGPSGRLLPARAGAAARGAKMAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVDLCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALQLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITALKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIINTHLAKLYDNLLEQNLIRVIEPFSRVQIGHISGLIKLSKADVERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT
The following text describes a protein:
Function:
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
Sequence:
MQIEVKKLEKYIDIYDIYDIFRVLMSQDNFKENKLSFLDSSLKNKYGKYSIIGINSYLELKEKDNKFYINDKLSDENFEEYLDRFLKENKQENKYDLPLISGGIAYFSYDYGRKFENIKTRHKKDVDIPEAVIRFYKTYIIEDIEKQEIYISYQDKKDFDNLINILENTKIEEENLIKNNNLANFKSNFEKDEYLKAIKKTIDYIIEGDIYIMNLTQRLMIESKKSPLQVFSYLRKFNPAPFGAYLDFDNFEVVSASPERFIKMKDRLIETRPIKGTRKRGATTEEDLALKNELANSEKDKSELLMIVDLERNDLNRICELKSVVVDELFEVETYSTVFHLVSTIRGKLKEEYSFVDLIKATFPGGSITGAPKIRAMEIIDELENSRRDLYTGSIGYVSFNGDCDLNIVIRTAIHKEGKYYLGVGGGITCESELDFEYEETLQKAKAILEAIC
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Subcellular Localization:
Mitochondrion.
Sequence:
MARNLCRNVQTTPRPLTALSLRRMVTPFHDLELQGSHCPRPRYFGSSTAKSAKKKSNNKAYSGSSMSAGDASAGPSRYPPLPEGWQAVIGIECHVQIKDKHKLFSTAELPTPSTPPNTLVTAFDAAHPGTLPTLNRSALRLAARTALSLNCQIHAESRFDRKHYFYSDLPAGYQITQKYMPLANNGQIKLLFDEGHLPSPEDEITVEIEQLQLEQDTAKSSYFDIGTTFRLDQASLADASNAEASPGAILHETDDDRVDRSFVDLNRAGAALMEIVSGPQMRTPEQAGAYVRKLQQLVRRIGASDGNMQEGSLRCDVNVSVNRIGEPFGTRCEVKNLNSVRFMMNAISFESHRQVKLLQQNGRVEQETRGYNESDGTTFRLRGKEDAPDYRYMPDPNLPPILLSEQQLHELRHGLPELPDARRARLVEQYGLSSRDINVLMRVGSEDERDGRIATQSLDTHAQQQTSSDAVDYFEQVATGRSAQTALNWIIHELMKGLNARNLPFKEWYLPAEYLGQLIDLVEDGQVTGTTAKTVIADLLSSAQSGHDGKTCLSLAAVRALAQSSSSPVFDLLKQRGLLALNTKKDLMPLVESAMERLPDEVAQVRKGNLKVAMRIVGQVMKDANGRANAKLVHQTILEQLGPTSAP
The following text describes a protein:
Function:
Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome. In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage.
Subcellular Localization:
Cell projection, dendrite. Cytoplasmic vesicle membrane. Early endosome membrane. Endosome, multivesicular body membrane. Golgi apparatus, Golgi stack membrane. Golgi apparatus, trans-Golgi network membrane. Late endosome membrane. Lysosome lumen. Membrane; Single-pass type II membrane protein. Recycling endosome membrane.
Sequence:
MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKVVVKTKTEYEPDRKKGKARPPQIAEFTVSITEGVTERFKVSVLVLFALAFLTCVVFLVVYKVYKYDRACPDGFVLKNTQCIPEGLESYYAEQDSSAREKFYTVINHYNLAKQSITRSVSPWMSVLSEEKLSEQETEAAEKSA
The following text describes a protein:
Function:
Required during male meiosis for completion of spermatocyte cytokinesis and possibly also required in female germline cells. Also involved in ring canal formation in male and female germline cells. Not essential for cleavage furrow ingression but is required for contractile ring stability and the attachment of the furrowing membrane to the actomyosin ring in late telophase. Displays high binding affinity for beta-galactosides.
Miscellaneous:
MISCELLANEOUS: The name 'nessun dorma' is based on Pavarotti's famous aria from the opera Turandot due to the interaction of nesd with Pav.
Subcellular Localization:
Midbody. Note=Detected in the midbody in late cytokinesis. Also detected in ring canals in testis and ovary and in the fusome.
Sequence:
MEVFTFEKSYLERLKEAEAVLSWEGAVMPASQVRSEWKSYVELKIEPAGWQAIWKIPRVICEDLKLRYPTIVYGYVEQVIFDELKAVFVVTAVQDSDVHLPESNEVSLVELWPTVQQENAALNVDTTAECIDRLRFFYTHVWMPWDKDYDDDRDWVQQHLQARIQLVCDLSKNRLPRPLALHMRTLLAEAKYIQQRLDYLELDLSDAESDDEAVELNDSVAEPARKQSKAGSANGCLNVSSLPVTDLMCLHLRMAIIRSEFEILENPEMRRAYSELQSNSLKRLRCSSGRTRQSEDLLVERNSISHVVTLPGKLQQQLELLKLAQTLVKPESKVQLSNTLQDVLSICQSNDDILLSPGEHTIKFLEHLNDNGSLRGLTQPEAILSPAADLSLLPVVCSSDEDSTLLVIDGDYTLSELVLDCRHVRRGILLRNGTLTMRGCRLLGDGSSSTQEGIVCMPGASVELKSCLIENFAVGVSMRPKSSAELGSVQFKTCKTGLELLEKSASVNLQGSKCSFENCALGILADGFVLGEQRTEKVLVLNKFSELQRYNEDNLLGNCSFYNCKKNVRVFNESGQLLAQRSHQQLLEDELGGENKENIQLV
The following text describes a protein:
Function:
Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor.
Sequence:
MCLALPGQVVSLMPNSDPLLLTGKVSFGGIIKTISLAYVPEVKVGDYVIVHVGFAISIVDEEAAQETLIDLAEMGV
The following text describes a protein:
Function:
Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse. May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli.
Miscellaneous:
MISCELLANEOUS: The protein structure is stabilized by calcium ions.
Subcellular Localization:
Secreted. Synapse. Endoplasmic reticulum. Cell projection, axon. Perikaryon; [Isoform 1]: Endoplasmic reticulum.
Domain:
The protein contains a globular N-terminal tetramerization domain, a long stalk formed by the coiled coil region and a C-terminal olfactomedin-like domain. Interactions between dimers are mediated by the coiled coil region. The dimers interact mostly via the N-terminal tetramerization domain, giving rise to a V-shaped overall architecture of the tetramer.
Sequence:
MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTRLSAASGGTLDRSTGVLPTNPEESWQVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQNMSQSIEVLDRRTQRDLQYVEKMENQMKGLETKFKQVEESHKQHLARQFKAIKAKMDELRPLIPVLEEYKADAKLVLQFKEEVQNLTSVLNELQEEIGAYDYDELQSRVSNLEERLRACMQKLACGKLTGISDPVTVKTSGSRFGSWMTDPLAPEGDNRVWYMDGYHNNRFVREYKSMVDFMNTDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSHIIIRFDLKTEAILKTRSLDYAGYNNMYHYAWGGHSDIDLMVDENGLWAVYATNQNAGNIVISKLDPVSLQILQTWNTSYPKRSAGEAFIICGTLYVTNGYSGGTKVHYAYQTNASTYEYIDIPFQNKYSHISMLDYNPKDRALYAWNNGHQTLYNVTLFHVIRSDEL
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Sequence:
MLRRRLTSLLLRSPCSSSVASSYHHQQHRLLLPTHAEKPPALNLLRLFTSLAGTDGDRPFIAFVLGGPGSGKGTQCSRIASDFGFSHVSAGDLLRNEISSGTDQGEWILEIIREGRIVPSEITVELVRKAIESSTAKRVLIDGFPRCEENRIAFEKITGTEPDLVLFFDCPEDEMVKRLLSRNQGRVDDNIETIKKRLKVFESLNLPVVEYYSSRGKAHKINATGTEDEIFEAVRKLFSSLRL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLENLALITSLGCWCGAEDEEGLSERSISVQGGSQIRTVKAALSTQKANPYEICGPVLSDTFHLAEYKGTHRGQKLLMCGACEKPLYFRAHCHQDQKQHIGEKPLRSDVRRALFVNSSKFHVSGKPFSFGGVGKDLLGNSEFLHQQAPPTWEKSNCGTKSEATFPRENNHYKWGDSTKTLSCKHTLVQHQRVLTRGGCYMCSECGKSFSKSSHLIRHQSVHTGEKPYECSECGKSFSQSSNLIQHHRIHTGERPYECSECGKAFIQRSHLIQHWKVHTRERSFECKECGKSFTKSCSLIHHQSVHTGKKPYECSECGKSFSQNSVLLRHQRVHTGESPFVCSECRKSFRQSSALLQHRRVHTGERPYECGECGKSFRYISNLITHRRVHTGERPYECKECRKSFKKSSSLHQHQRVHTGKRPYECSKCGKSFRQNVVLLQHQRVHTGERPYQCGECEKSFRYISNLTTHRRVHTGEKPHECNECGKFFSQSSNLITHQRIHTGKRP