lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Key component of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation. RqcH recruits Ala-charged tRNA, and with RqcP directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal alanine extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.
Sequence:
MALDGIFLFSMINEMKTKILNGRVDKVTQPEKDEIVLSIKNNRKTYKLLISSSAVYPKIHFTDIPKKNPMQPPMFCMVLRKYLNSSKIINIRQLDTDRIVLIDFESADEMGFNSIYTLIIEIMGRHSNITLVRERDNLIMDSIKHVTPEINSVRNLYPSIEYIYPPASLKLNPFNFSLKDFKDYIKDNNVKLNKTMFSNIFTGVAMPFSKEILYRLEKENNLEITLENMDEIYVVTKNIFDSIKNKEFCFNCYLEKDTVKDFYCVNLHSLYNFKNIDYENPSLLIESFYFEKDKSDRLNSKSSDLQKLINVNIERCEKKIKILEGNLKDCNEREKFQICGEILTANIYALKKGMDKVNLLNYYTNEYMDIKLDPNKNPSDNIQKYFKKYNKLKKTEVAAKEQIELTCDELKYLNSVLTSIKNADSYDDIEEIKRELIETGYIKFKKKNNKKFKNTKPLHFISSDGIDIYVGKNNIQNDYLTLKFASNHDIWMHTKNIPGSHIIVKNFQGNVPEKTLEEAATLAAFYSKSKDSTKVPVDYTEVKNVHKPNGAKPGMVIYYTNKTIFIDPKEPNLKQI
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MKMKIGIVGPGAIGLLYTFYLQKSNQDVTLFTRTAKQAEELNETGVTCIRDGRCETVYPPVLPIESMVAQNLDYIFISVKQYHIDDVLPFVEGASSLIFLQNGMSHLQKMLKIGSENIAVGIVEHGAKKEGGHIVHHTGIGVTKFGVVCGQSIHFKKIFRYFPVTYFPVQIETDWEEIMHKKLVVNVCINPLTALLGVKNGELITNRFFYQMMEQVFQEVAFLIRGEKEMVWQMVRNVCEGTSRNTSSMLADVRANRQTEINAIVGYVLEEAKKQQLPVPTLQFLFDAIKGLETRV
The following text describes a protein:
Function:
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular Localization:
Cell membrane.
Sequence:
MATRLLCCVVLCLLGEELIDARVTQTPRHKVTEMGQEVTMRCQPILGHNTVFWYRQTMMQGLELLAYFRNRAPLDDSGMPKDRFSAEMPDATLATLKIQPSEPRDSAVYFCASGL
The following text describes a protein:
Function:
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds that are building blocks of archaeal membrane lipids.
Sequence:
MTIGIVSYGAYVPRYRIKIEEIARLWGDDAEALKNGLMVYEKSVPDVDEDAATIAVEAARYAMARSGVDPSRIGAVYTGSESHPYAVKPTSTIVAQAIGATPEMTAADFEFACKAGTAAVQACMGLVGSGMIDLGLAIGADVSQGAPSDALEYTAAAGGVACLIGRKESELAAIIEDTYSFTTDTPDFWRREGMPYPEHGGRFTGEPGYFKHVTNGAKGLLEKLGTKPEDYDYAVFHQPNGKFPSKAAKILGFTKAQITPGLVVPKIGNTYSGSCLMGIAATLDQAKPGDRIFATAFGSGAGSDAFSITVTDRIEEIRNRAPKVSELIKDPVYIDYARYARHKGKIRLA
The following text describes a protein:
Function:
Involved in the degradation of nylon-6 oligomers. Degrades cyclic and linear oligomers of 6-aminohexanoate (Ahx) with a degree of polymerization greater than three by an endo-type mode. Cannot use Ahx cyclic dimer or the Ahx linear dimer.
Sequence:
MNTTPVHALTDIDGGIAVDPAPRLAGPPVFGGPGNDAFDLAPVRSTGREMLRFDFPGVSIGAAHYEEGPTGATVIHIPAGARTAVDARGGAVGLSGGYDFNHAICLAGGAGYGLEAGAGVSDALLERLEHRTGFAELQLVSSAVIYDFSARSTAVYPDKALGRAALEFAVPGEFPQGRAGAGMSASAGKVDWDRTEITGQGAAFRRLGDVRILAVVVPNPVGVIVDRAGTVVRGNYDAQTGVRRHPVFDYQEAFAEQVPPVTEAGNTTISAIVTNVRMSPVELNQFAKQVHSSMHRGIQPFHTDMDGDTLFAVTTDEIDLPTTPGSSRGRLSVNATALGAIASEVMWDAVLEAGK
The following text describes a protein:
Function:
Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon.
Subcellular Localization:
Cytoplasm, cytosol. Note=Exclusively cytoplasmic.
Sequence:
MYFSWAAGSRKPRRLKAGTSGIELLQAASGEHHSLLLFSNHRVYSCGDNSWGQLGQRRDQSTERPEPIQALNDLHVDLVSCGKEHSVAVCHKGKVFAWGAGSEGQLGIGEFKEISFMPTKIKALAGIKIIQVSCGHYHSLALSEDGHVFSWGRNSEGQLGLGKNSRSQAIPQKVKSLEGIPLAQVAAGGTHSFALSLTGTSFGWGSNRSGQLALSGNKVKEQIYKPHSIGALKNLSVIYISCGYEHTAVLTEEGQVFTFGGNSSGQLQPSPRSGQRGPQLIEGIGGRVSQIECASYHTIAYVYTTGQVVSLGRGPSHTSNPTHQEAPAENSDITCLLAAEDLVDIEVKDIFAGAHANFVTTRRVSHTRSTGVSMKILPEIIRINQSLVKKWRAANKRKDREGAKREISLIFSSSACLTASFLKKRDAGENNLIDVDLKLARDVFKKLTTEKWISSLITTCLEEYLLRDLPYSSPHQEALLVFLLLPECSIMQDPKNWKTLAFEFAKAIHKMGPQSLAFLRTCWASLEVSSLNILVQMLKKAIISQIQYGVATEQYITNIKVLLEVIKEVHKANCQLPESAFIINELSGIFNFDAEAGRMFIRHNDLDCTESSDMVVFSDFLFVFDLPSKIKLMKCDSFVKLMSEVMAFPEKMSSPPYLILKVRRSHLVEDTLRQLRQVEDFDLRKQLSVGFINEIRPEAGGVSSEFFHCIFEEMTDPKYEMFIYPEKGSSMWFPVNPKFEKSSYFLFGILCGLSLHNLKVINLPFPLALYKKLLNQKPSLEDLKELSLPLGRNLQEVLNCEAGDIEELHMYFSIYWDQKDVDLIPDGISVPVNETNKRDYVSKYVDYIFNISIKTIYEEFHRGFYKVCNWDIIRQFQPEELMTAIIGNATCDWKQFENNSKYKDGYDKSHPTILLFWKAFHDLTLDEKKKFLLFLTGCDRLHVKGLQNEGIVFRCSETFSEEDNPRSLTCHRMLDLPKYSSMRRMKEALQVAINNSTGFVSQE
The following text describes a protein:
Function:
Required for activity of the reductase.
Subcellular Localization:
Cytoplasm.
Sequence:
MTLLNDIQVWTTACAYDHLIPGRGVGVLLDDGSQVALFRLDDGSVHAVGNVDPFSGAAVMSRGIVGDRGGRAMVQSPILKQAFALDDGSCLDDPRVSVPVYPARVTPEGRIQVARVAV
The following text describes a protein:
Function:
dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs.
Sequence:
MPGAVDFKERISRQRPHDRETYGHAGNTDLQDIVYQLESDRGRIVNSAAVRRLQQKTQVFPLERNAAVRSRLTHSLEVQQTGRFIVRTLFRQLGPRAAEVGLDGLEGALESLVEMACLMHDVGNPPFGHFGEYAINDWFERNLDALFERRIPPGQGDGLLQQRMLTDLKHFEGNAQAIRLVVKLLRLNLTYTQTAGLLKYVRPAYEPKPDKAAANHYLNKKPGFYLSEEAFVDELRRVLGMRPGTRHPVAYIMEAADDISYCLADIEDSVEKGILDIRQLADLLVKKFAVHHSPDAPIPGDADNMSFQRMVDYSLEKAEREPINKVSEFFIRLRVKMIHPLVQHAAQQFIDNFEAVHAGTLGRALMEDGSLPHAIVQTFKDVAMEWVFCHPEVETLELQGYRIIQGLLDFYAPLLRLPAEEFQALAEGRQAAAPHPQLLVRRLPSQQIKAYLEAMKGVAEDPLQRQWEFYHRCRMLQDFVSGMTDQHAQDEYRALSAL
The following text describes a protein:
Function:
Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Peroxisome.
Sequence:
MAYKPEGLFEHILIHYRWVFVCLFLLPASFFFDIWLYVRNWIVFKLSSAPKQHHSKVKHVQTQVRNWIKNGRKQFMCTARPGWQTVSFRRPKYKKTMYNVEVNLVDVLDINLEKKTVRVEPLVTMGQLTATLNPLGWTIPVVPELDDLTVGGLVMGTGIESSSHKYGLFQHICVSYELVLCDGSVVTCSTQENPNLYYSVPWSYGTLGILTAVEIQLIPAKKYVKLTYKPLKTLDQVTQETESASKDLNNEFVETLVYSKDKAVLMTGIQTDQVDENKVNAIGKWYKPWFFKHVEGMLETNKTVVEYIPLRDYYHRHTRSIFWELQDIIPFGNNLLFRFFLGWIVPPKVSLLKLTQTEAVRKLYENNHVIQDMLVPIETLKASIEKFHEVLEIYPMWICPFKLPPNPGMVHPPLKNYDTDPVYVDIGVYGVPKAKNFTPLGSTREIEKYVSNGNGFQMLYADTYMSREEFRRMFDHRLYDSLRASLGCESAFAEVYDKVSRAARE
The following text describes a protein:
Function:
Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTLAASSQRSQIIRSKFRSVLQLRIHRRYQDPTLSGSFTASPVLDPDPWISAADPALALAPASPLGPAPFLFNPEVLLPEPKPCWSLKKESPKTSQHWREPKPKGNLTYHQYIPPEPRQGYRADPQVEGSPLDPPGPPLWEGTTSQQPPPRMKPTPLTPSPPGVPSPSPLPHKLELQTLKLEELTVSELRQQLRLRGLPVSGTKSMLLERMRGGAPPRERPKARREDSAAGAPWPRFRPKALGAARSACSFKLSPTSHSPPPPRAVETLVTASASAPVPVATTAQAPTPAPVPVPSSAPASTALTLEEELQEAIRRAQLLPNRGIDDILEDQVEPEDPLPAIPLDFPGSFDMLSPSPDSEGLSSVFSSSLPSPTNSPSPSPRGPTDFLDWLEALSGGPSLGCGPPAPSIFSADLSDSSGTRLWDLLEDPW
The following text describes a protein:
Function:
Involved in the biosynthesis of UDP-N-acetyl-alpha-D-glucosamine. Catalyzes the formation of N-acetyl-D-glucosamine 6-phosphate from acetyl-coenzyme A (acetyl-CoA) and D-glucosamine 6-phosphate.
Subcellular Localization:
Glycosome. Note=Predominantly located in glycosome microbodies in the bloodstream form of T.brucei.
Sequence:
MTDIVDLELRVLEESDLSSHLELLGHLTEAPPLSGVELANIADMRRRAGIVTKVFCHQPTGRIVGSASLMIQPKFTRGGRAVGHIEDVVVDPSYRGAGLGKALIMDLCEISRSKGCYKVILDSSEKSLPFYEKLGFRAHERQMRLDL
The following text describes a protein:
Function:
Induces oocyte maturation and ovulation in vitro in ovarian fragments and induces spawning behavior and gamete release in vivo. Probably mediates its effects by binding to a G-protein coupled receptor located in follicle cell membranes. Following receptor binding, stimulates GTP-dependent adenylyl cyclase activity in follicle cell membranes of fully grown ovaries at stage V but not in young ovaries at stage IV, leading to the production of cAMP. This stimulates the production of the maturation-inducing hormone, 1-methyladenine, in stage V but not stage IV ovaries. The lack of activity in stage IV ovaries may be due to the very low levels of the G-protein alpha s subunit which is not expressed at high levels in follicle cells until stage V.
Subcellular Localization:
Secreted.
Sequence:
MTSNNRHLFQATCLVLLLLHAAFHGGALGEKYCDDDFHMAVFRTCAVSKRSQPGMSLSDVLTMNRFRGHNIKRSIDSTLEDNAFFMSGLEKRSEYSGIASYCCLHGCTPSELSVVC
The following text describes a protein:
Function:
May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPVDAPLQKFRPRCAQRLAEILKPDALDEETRRQILRNVCADAAVTTNDGGCSVVSEEVKLGGSSGTGGNFSTMLRDRVATANSELVTAMTKRLKMLEAQQQAYRLELKEKTEKLNRMQTECEAEKSRREEAETLVVELFSDKEELEKQIMEMKEFLADYGLQWVGNAEGESGGGSSRTPKERAKKSPATLAAETSPIPNREMKRFDLYAGDYTSEAPSPRPESSSLAAAESRSTNMSPARGECSLPVSMEILQKNARILSDHVGFKEVATNGKRGAIKDRDVVQIVVYKDGICVNSGPFRPFGWPLCDAVLNDIAEGYYPYEFKQRYPDGFPIEIVDQTSVCCTAVGTRPKNDKVQGTERMREGGYQPVSREEFLKRLPTTRITAGGRIVDVQGEIAKIIGCDKGGPSGSAEPDDASLMRHVTASEQKKRGNVSKSDGECGAPVATGTETPNNRCNNTRLQLIEGLVAVQLRFPCGKRLVLNLSPEDTIGDLRREVRLAMPSFTTEYKICLPFPAKTLGDDSKTLAELGLLGTCTLMIQPPRETKS
The following text describes a protein:
Function:
Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Required for mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking.
Subcellular Localization:
Preautophagosomal structure membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
Forms a homotrimer with a solvated central pore, which is connected laterally to the cytosol through the cavity within each protomer. Acts as a lipid scramblase that uses its central pore to function: the central pore opens laterally to accommodate lipid headgroups, thereby enabling lipid flipping and redistribution of lipids added to the outer leaflet of ATG9-containing vesicles, thereby enabling growth into autophagosomes.
Sequence:
MPTHNSHSQPSSEDEGPPQSIIFGDHKLPEHPPTPNSPLQQTTNPFILESDGPHRQPHQSTIYSPGPFREPSTSRSPSHSRSRSTSPANSPGHSTISALASQSGVTASAGLGMTGADTAAASSKPTFREVPVPLSPTALSRQTSKSPAKSPRMGKGEGYLDPTILSVASGSRNSGKGKERTRRKGGHKYHSLHVQDEEEEEPPESDALRTRGKVGLNAYEKALWKWVNVDDLDGFLQEVYDYYKGKGIYCIVLARVLNLLTTFFVIAFSTFLISCIDYSKLFSSISTAEAVGRLEDVLVAQCITKGSFAHTLFLIILSAFFIFQVASFAMSVPRLLDMYRFYTHLLGVPDADIQTLPWPEIVRLIGDIRKHNPVTSLSNGQATALADMVGNDAKAPAKKLDAHDIANRILRQENYLIALFNKDLLDLRVRIPVPHVLTAFIPSSILISSADAPLPSLQSEPERKFLSFGANHLTKALEWNLRFCLLGYLFDRRGQVRKEFVREKRRKDLVQGLRRRFIFMGILNAIFAPFIILYLLIYSFFRYFEEYHKNPSSIGSRQYTPYAQWKFREFNELPHLFERRLDRSYEIAKEYVDQFPKERTALVMRFVAFIAGSFAAVLLVASLIDPDLFLHFEITPHRTVLFYLGVFGSILAISRGMVPQENMVFDPEASLNEVVRWTHYLPVEWRGQLHSQMVHQEFSKLFALKIMIFFSELLSVILTPFILFFSLPPCAAAIIDFFREFTVHVDGVGYVCSFAVFDFARYGNVDANQPETGLEGATGPDGGPAADGFAAGKPSRPTTRRTTSSSPSRLKHRDWRGNENKMEQSFLHFKATHPDWQPSDPSSSLFLDRLMGAGTRNRHGGGPVSAATGGISGSIYGGGGGGVGGRGLGVDGSVMAEMEEERLRAKRQSYERAWAKSSHLHRPDSSHSHPLRHPHSAASEIIEEEEGGEGDKGDDSIDGWSKRVKTDGETDDEEERERLWKDEGVVGLLQQVLGR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Sequence:
MADVDPDTLLEWLQMGQGDERDMQLIALEQLCMLLLMSDNVDRCFETCPPRTFLPALCKIFLDESAPDNVLEVTARAITYYLDVSAECTRRIVGVDGAIKALCNRLVVVELNNRTSRDLAEQCVKVLELICTRESGAVFEASGLNCVLSFIRDSGHLVHKDTLHSAMAVVSRLCSKMEPQDSSLETCVESLSSLLKHEDHQVSDGALRCFASLADRFTRRGVDPAPLAKHGLTEELLSRMAAAGGSVSGSSSACKPGRPSTGATPSASDSKLSNQVSTIVSLLSTLCRGSPVVTHDLLRSALPNSMESALGGDERCVLDTMRLVDLLLVLLFEGRKALPKSTAGSAGRIPGLRRLDSSGERSHRQLIDCIRSKDTDALIDAIDTGAFEVNFMDDVGQTLLNWASAFGTQEMVEFLCERGADVNRGQRSSSLHYAACFGRPQVAKTLLRHGANPDLRDEDGKTPLDKARERGHSEVVAILQSPGDWMCPVNKGDDKRKKDASKEEEEGSEPKGDPEMAPFYLKRLLPVFAQTFQQTMLPSIRKASLALIRKMVHYSSEVLLREVCDSETGHNLPTVLVEITATVLDQEDDDDGHLLALQIIRDLVDKGGDVFLDQLARLGVINKVSTLAGPTSDDENEDEVKPEKEEEVQEDAKEIQQGKPYHWRDWSIIRGRDCLYIWSDAAALELSNGSNGWFRFILDGKLATMYSSGSPEGGSDSSESRSEFLEKLQRARSQVKPATASQPILSMVGPTKLTVGNWSLTCLKEGEIAIHNSDGQQATILKEDLPGFVFESNRGTKHSFTAETSLGSEFVTGWTGKRGRKLKSKLEKTKQKVKSMARELYDDHFKAVESMPRGVVVTLRNIATQLESAWELHINRQCLEGENTWRDLMKTALENLIVVLKDENTISPYEMCSSGLVQALFTVLSNSVELDLKHDCKPLMERINVFKAAFSENEDNESRPAVALVRKLIAVLESIERLPLHLYDTPGSSYNLQILTRRLRFRLERAPGETALIDRTGRMLKMEPLATVESLEQYLLKMVAKQWYDFERSSFVFVRKLREGQIFTFRHQHDFDENGIIYWVGTNAKTAYEWVNPAAYGLVVVTSSEGRNLPYGRLEDILSRDSSALNCHTNDDKNAWFAVDLGLWVIPSAYTLRHARGYGRSALRNWVFQVSKDGQNWSTLYNHIDDGSLNEPGSTATWPLDPSKEEKQGWRHIRIKQMGKNASGQTHYLSLSGLELYGTVTAVCEDQLGKAVKEAEANLRRQRRLFRSQVMKYIVPGARVIRGIDWKWRDQDGNPAGEGTVTGEAHNGWIDVTWDAGGSNSYRPASSTVGPSATPAAVGGTTITTSSSSTTSSSSQQPSWSSLVKNNCPDKGGASSSSRKGSSSSVCSVASSSDISLSSSIGLPGAGSLQLDRKAEGLLLDQAAGVEGVTGGGTGSDGHQQEPIVVLSSVTESGSASSSGTLTADVSTAGDEHHSPSAMATAVDPATAISMGLVSVSSPDVSSVSEPSSKDTHSQRPLCSAVNTRLSVSSLLAASAPMSSSASVPNLSSREASLMESFVRRAPNMSRTNATNNMNLSRSSSDNNTNTLGRNVMSTATSPLMGAQSFPNLTTTGTTSTVTMSTSIVTCGNNVATATTGLSVGQLLSNTLTTSLTSTSSESDTGQEAEFSLYDFLDSCRANTLLAELDDEEDLPEPDDDDDENEDDNQEDQEYEEEEEEYETKGGRRRTWDDDFVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGTPRSEVREEVECAPSPHLALTLKVAGLGTAREVEIPLSNYKLTIFYYVQRLLQLSCNGAVKTDKLRRIWEPTYTIMYRELKDSDKEKESGKMDLFEHVVGSRSGGLSPSSGSANQSSEILGWAKEAVLAKAGCSQNACGVEDVLQLLRILYVIGRDSTAGGRTLQEDVDELQFNSPPEEFSSKKITTKILQQIEEPLALASGALPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQNRREATMERSRPSTTVRRDDPGEFRVGRLKHERVKVPRGESMMEWAESVMQIHANRKSVLEVEFLGEEGTGLGPTLEFYALVAAEFQRTSLGIWLCDDDFPDDESRQVDLGGGLKPPGFYVQRSCGLFPAPFPQDSEELERITRLFHFLGIFLAKCIQDNRLVDLPVSQPFFKLLCMGDIKSNMSKLLYQSRGSPQGHLSERAPLLLLTEVQSEASTEESQETYSVGSFDEDSKSDFIMDPPKPKPPAWFHGIMSWDDFHLVNPHRASFLKEVKELAVRRRQILTSKSLSEDEKNTRLQDLMLRNPLGSGPPLSVEDLGLNFQFCPSSKIHGFFAVDLKPNGDDEMVSLENAEEYVELMFDFCMHAGIQKQMEAFREGFNRVFPMEKLSSFSQKEVQMILCGNQSPCWTADDIISYTEPKLGYTRDSPGFLRFIRVLCGMSTDERKAFLQFTTGCSTLPPGGLANLHPRLTIVRKVDATDSSYPSVNTCVHYLKLPEYSSEEIMRERLLAATMEKGFHLN
The following text describes a protein:
Function:
Peptidoglycan polymerase that is essential for cell wall elongation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MELAKLSWNSWLNSLYKLFRGFDGWLLLFAVLLLSTGVLTIFSTRPEGIEWKAQLGTGLVGIAWALFLSRLTYGWLQRWSWLIYSSACAMLLGVLFTGNSVKGAQRWIEFGGIQLQPSEFAKLGVIIALAALIQRYPIRSFGQIWVVLGVLAVPFLLVFKQPDLGTALVFGAISLGMLYWGGARLGWLALVVSPLMAAILYAIWIPAWIVWVAAMAVVAWRELDWRWWGAIGAGAINLVAGGLGQVFWHLLKPYQQQRLVVFLDPSGDPLGSGYHILQSEIAIGAGGLWGRGIFQGTQTQLNFIPEQHTDFIFSALGEEWGFLGAVVLLGLFFCLFARLLLIAQNSADDFGSLLTIGVFTMLLFQTVVNIGMTIGLAPVTGIPLPFVTFGRSFLITCFTAIGLVESVALHRTKMVFPN
The following text describes a protein:
Function:
Possible role in modulating immune responses. Has an inhibitory effect on lymphocyte proliferation. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation (By similarity).
Subcellular Localization:
Membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Note=Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm.
Sequence:
MIHVYTSTGAWGWAGSCCWLWSFCPPACIGCIEEHLLSWPQVQGSSEQEIHYASLQRLPVSSSEGPDLRDRDKRGTKEDPRADYACIAENKPT
The following text describes a protein:
Function:
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Sequence:
METKVKAHVAPWKIEEVKTLKGLIKSKPVVAIVDMMDVPAPQLQEIRDKIRDKVKLRMSRNTLIIRALKEAAEELNNPKLAELANYVERGAAILVTDMNPFKLYKLLEENKSPAPVRGGQIAPCDIKVEKGSTGMPPGPFLGELKSVGIPAAIEKGKIAIKEDKVVVKKGEVVSPKLAAVLDRLGIKPIKVGLNILAVYEDGIIYTPDVLKVDEEKLLADIQAAYQNAFNLAFNTAYPAKEVLPFLIQKAFINARALSVETAFVTKETAGDILAKAQAQALALASKLPDEALDEDIKAKLSSVEVSAAPAAEEEKEEEKKEEEKKEEDTGAAGLALLF
The following text describes a protein:
Function:
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Sequence:
MSNRVSTGKMAMAPQESVQPAVLYKLVLFALLMAVVPIGTYFSTLNYLWDGSTTFAAISAIAAANLILVGYVVVAFREDAASRTGPLPEKKTS
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MSWMNLFGSSSPNPTSNELPAPTALQQQRSKQIETLRIFHHSVTEVQRDVEYRVTFTVGSSTLFLNVTLPPQFPQEKPVVKVSPPVIHPWVNDQMIVVGCQAINSFYMHSSLGKAVQEVVRELCDHPPQIVNQPSANPSSSLPGFQPISSNSFPGYQPLVTPFSSSQFGISNSTHGLFPSSSSSSSESQTASLITTSEVDSPSRKNTAAVAIESKEFPELNGLSLEELKNLNDSTDLLEEFQLNLESVKKLQEEQENLMLQNEEIARYNLSLQPKLEACKDAIIRNYELLNEKQQEFVKKNQVQKDLITAYSLANIHTNLEVAASQAELESDEIADEFLDGKLKVEDFISKFIDKRKPSVCFILSFDNFQEASILCHRESGLLTTMCNPIGFEPSI
The following text describes a protein:
Function:
Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cell projection, cilium, photoreceptor outer segment. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Late endosome. Photoreceptor inner segment. Synapse, synaptosome.
Sequence:
MAVVLSTTSNMSKSLKKKSHWTNRVHEVVLSRGPSGDLGFELQGGAENGQFPVIGEVKPDRRKLQQDELLLEVNDTPVAGLTIRDVWAVVRHCKDPVRFKCVKQGGVVDKDLRQYLNLRFQKGSLDHELQQIIRDNLYLRTVPCTTRQPREGEVPGVDYNFVTVERFVELERSGALLESGTYEDNYYGTPKPPAEPSPLLLNVAEQLLPGATPTSQGKRRRNKSVSNMEKAGIEPPEEEEEERPVINGNGVAITPESSEHEDKSTDASGEMATTCPSETSTDAPKEDTEPPKSPPKPDENDELGPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRRLQHQQQMQSQGLSSLPLPAVYREKPLFTRDPTQLKGSFLSTPLQKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMATGDVIVYINDVCVLGTTHADVVKLFQSVPIGQSVTLVLCRGYPLPYDPEDAANTLLSPLGLIDRPLLVNGRNSYDSYMEYISRTARFVDPLQTTMVQPHPGDTHLDAGPLEDSVSMASSGAAGGELLTINMVKGADGFGFTIADSNGGQRVKQILEAQGCPGLCEGDLIVEINQQPALTLSHTQVVELLKECPIGTEATLVIQRGGTGHFSPWKTTKQVLEHWDPLSSPTTSLSVHALPHSAPYLHWPSGPEFDLAKPDPYDLYEKSRAIYENRQPGLPRASLPADPSAEFQEVEVHLRRQKSGFGFRILGGEEPGQPVSPKAQEKILIGAIIEKSPADKDGRLRPGDELISVDGIVVAGKPHRYVIDLMHGAARTGQVKLTVRRRVQPTGEPFPENGRSPGSTQHSSPRSDFNSRMFCNNSAPSQNSAPSTTGSSPPDTAANQNAQPNDVSIQRKETEGFGFVIISSLNRPETAAAAAVPHKIGRIIEGSPADHCGKLKVGDRILAVNNQSIVNMPHADIVKLIKDAGLSVTLRIIPQEETNSTPSAGSSEKQSPMAQPSPVCQPNTVNQTGAAPLANSNAQQNSAPQPSPIKQPISEAQPSLVTQNSPANHPSSVTQQNPQTQPVQTYSHDSSYRSEVKARQDVKPDIRQPFTDYRQPPVDYRHPPVADYRQPPTLDYRHPPLLDYRPLPADPRTFPLPDYRMPQDFDFFTVELEKGMKGFGFSIRGGREYKMDLFVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYADSPAPWDAHPTASPSLSEVAPPLDSLSNPSASSHVNPPTDPPHTSSLEAVGPDSCQGPRGSESRALEQASVGKRSALAGGVGGGTKQREGSRTNRRSSGGKGQQQYLDEFAGEPKSHKSSRAKSKERRRERSSTPSRKRDSPKTSLTDTSMNGGNGCLDGSNSQQGPLVPFKALPKEPEKGQMSQESNPSHNSKISSAAGRKATVSPGPWKIPGTDKLPSTLRSATSTISR
The following text describes a protein:
Function:
May play a role in cellular stress response.
Subcellular Localization:
Cytoplasm.
Sequence:
MIEEWASRQWTPRYFTDQLGDLPVKVKIGPNAATISSNNPILETDCCYEVCTMQEYNQWLNKDPNCGNLNQYDPDLCWCYVDYQYIALTFQAYPEIPQSIDWSKFGLNGRKGDQSTFWMGSKGASTPCHYDSYGCNLVAQLYGRKKWLLVAPDESQYMYPIRVPYEESSIFSAVNMKSPNLVSYPKFANVTIYEVILEPGDVLFVPKYWWHDVECLETAISVNTWIALPSDGMDRLCEAVTKTVVFALKSAEGNKITQWLNPSEVPTSYQTNIGYLKNSLEQLMPKLHTDFPNLYKDDLLDRVINSLLSPDLIKVAAERIISSFTASND