lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable transcriptional regulator, which participates in the transcriptional repression of the presenilin protein hop-1. Might play a role in the oxidative stress response.
Miscellaneous:
MISCELLANEOUS: Loss of function results in a suppression of sel-12 phenotypes, possibly by up-regulating hop-1 expression.
Subcellular Localization:
Nucleus.
Sequence:
MSSEPTSSIESDNLRRSKRKKFKLDFVAAAHGNNQKKSRKDPHGQGDDDDDTFDDDLNHFEPLSVLTEQDVSMEMFEDDEEDTVSRRRTRRSTAHFQDYQEPDRWIENSGPHACHKCPSRYESKSSLANHTKMHLGEKRKFACELCDFSASTLKSLTHHNNIHQNFGVLSQQTSPVIPVASSADSTLNSSINSTGCQINAPPAPKLDEEAPIAVESVVVHHEDVAEFDTTPPPILEREDDGPPVLIREAPVRKSNRPMKPTQKAQKMTKQRERKSKTVESPKGSLPSSSASSVTPPPVRKDVEKPKIFVKTTKKNLKKTMKITKVRQRCPHCPFTTSTVTRLNRHSGGHKLKEGYICPSENCNFMCRKAGFLQKHYILHKGTLPWPPEYVKKGGAKMKRTFPESEEKKIEVTEKVQKMKKMHKRRANTVQVVAKAQLKSYIKVEVDDVIFKKCNIGECEFLTQTLTQLIVHKVKTHDTKTAFPQHRFLCLTCGHRAKSYAALRTHKLIEHTSTHKRFHRTYYLKECVGDKFFVKYNLSKVQEEVKEEPKEADGDESGDESFDSMCPASDVHPETLAAIEMKDVFFCCNMCPYKAPTMNRCQRHYDKHFKNDEFKCQYCSWSSRSKEVIVNHEKLHPTVVVANTNEAPVVKNEIEAKVEVLSKTVSSPVECTEESSLSKSIQLWCQREKLRHPELDEQFTRKMIDGVKGFQCTDCPYTSKYRGDMRSHKKRHDIEQLYRCVQCTYTTNRPVSLKDHLKQHAIVNMSIADIKSRRVVVNQGVKIGMRRGVGKDKIYCCDKCPYVTLALGCLWRHHRNHRDTAKINICSNCSYSSIDQRKMEEHTIIHLGLGLNEAVPFVKRVDQKGRPVSSLTDLNSEKMNERKSTKRKMLDKVEKMEVGEDEEDDEESVDKGTDDGDYKQRPEKKRKQSSEEPASDPELFGSSSQPTRQLSERATRNRINYSLLSKNGSGKPTPSTSSANLEKLAGSSGGASSESPEPDESVEVSHWKIRTFLRSEYGVKESLKCPDCPYKSSEPDVLEKHRYYHMTKTTPRPYACSDCTFNTYTPTALLQHLKLHSEGVYFDPMVKKHMKHRKGDSIPPGVKGYYCKNCSFKTSIHRNFIEHSAYHRQQLINRINITLKRQPPRIEYQRPKLKHQFVAKNAKYCKKCTFKCVSQSNFIEHLDRHGWNQLYKCYSCDYSDNTKSVVDFHQLNHHIVKDQTLHSICQSAKFRLENGVIQIPEFQTEKSKPTPDEFVSKTRGLLKCPSCEYFCHVSSELAFHMSVHHLTEPNARETISYLHMGLVPPKATVTTV
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MTLIASLSLPPPAIQRQSLSEFHNLPAKSQSFNCQFRSSSSPLSSLHSSSLSNFLDFRLRRRNSGLVPVVACSTTPFMGRVGLHWRDGNMSLLSFCGGTDVTEKADSSQFWSALLPFVVALTAVAALSYPPSFTWVSKDLYAPALGGIMLSIGIQLSVDDFALAFKRPVPLSVGFVAQYVLKPLLGVLVANAFGMPRTFYAGFILTCCVAGAQLSSYASSLSKADVAMSILLTSSTTIASVIFTPLLSGLLIGSVVPVDAVAMSKSILQVVLVPITLGLVLNTYAKPVVTLLQPVMPFVAMVCTSLCIGSPLSINRSQILSAEGLGLIVPIVTFHAVAFALGYWFSKIPGLRQEEEVSRTISLCTGMQSSTLAGLLASQFLGSSQAVPAACSVVVMAIMGLCLASFWGNGFRIRDVLSLSTPQSTGYTAES
The following text describes a protein:
Function:
Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAATDRSRSEAAKQRRQDQLQRWQGSETDRTGAEARSHSVAPGHRRARVRFAQGAVFMAACSAGDREEVAELLRQGADINHANIDGLTALHQACIDENAEMVQFLVENGSEVNRGDNEGWTPLHAAASCGFIQITKYLIEHGAHVGAVNSEGELPLDVATEDAMNRLLKAEVKKQGIDVDQARREEERVMLQDAMTVLAGSGSLVPHPNTQATALHVAAAKGYIEVLKVLLKCGIDVDSRDSDGWTAFHAAAHWGQEEACSLLAEHMCDMTAVNNVGQTPLDVADENIIDNLEELQKKQNAMRSEKQKIQTPVIETSPPVSMAPARPRRTSISRMSSREKITLHGREKHAPPTLQTLPTEEDEDESTRTASQSKPSSSSSSEEESESESDAESEKAKTREMINNLNNKRNAAPVTSSVTSSGPNQVKKTEAGRTPVTEAPGSWRTSLRKAGSSVTLGSTGASDAASEALKDPETKLGMTRSASSPRLSSEADNKEPRLARVQPTPSRRLFSISDNSTNSDNTSSLLSRSSSYTRRLNTQSASDASNPSLPRSSSYGRKLDESSVTSVNSATSGLSRLNNLVAQRSAQEEAEKKDPVSNSVTTTTTTTGESETKQRRKSYLTPVRDEEAEAQRKARSRHARQSRRSTQGVTLTDLQEAEKTMKTENKGKKEDEEKEGKQKKGEEGEVSWRSRIANLQKSDLLGLTHPPGAPRPDRPDADSIVADIEERMLERRKTRARRRGKPGESDDNEPSGEEESSGGREPQTDRHTSSRADSLLNDCILTRGADSRDFKKLFEEMSRENRRLQSQLSDTQRTISLTRVELENATKRQERFTDCTALLEMEKKEKKMLERRAAELEEELKVLGDLRADNQRLKDENGALIRVISKLSK
The following text describes a protein:
Function:
Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase (By similarity).
Subcellular Localization:
Cytoplasm. Vacuole. Note=Localizes to glycogen granules (glycosomes) in the cytoplasm (Probable). Localizes to the vacuole during nitrogen starvation-induced glycophagy (autophagy of glycosomes).
Sequence:
MTEAYISLLIGDGYLPGALYLANRIRQFDNERDLVILVSDISIKVHRLLERFYSKVVVLLPDSKIATSPYNAPELHLLNRPDLENVLNKIHIFHQTHYEKLLYVDLDVLILNDFKGLFDIEVKEWELYAVSDIGWPDYFNSGLMLFKPSANVFRHLLALLTEVPGVSYDGGDQGLINYVFQNKWLRTGDDTKRCGVWYNLSFAFNMTLSNNYESLPSVLRNLTDIKLVHFIGIVKPWMLKPSFVNDFPDGSLDSFVAQWWEQFSSFENGEFLPLVFKNVESERIEEDSHETEEKVDEEVSISEPQDETTDFKYQFGHHSFEEPAPVLDYSTEGEAWKLNEEQLTNQWDVDAPAEPLPVPVEEDEREETKAEAELEELLPDIVQPEPPAPHVFPWEAYNEKPTRVFHDYR
The following text describes a protein:
Function:
Inositol phosphate kinase with both monophosphoinositol and diphosphoinositol polyphosphate synthase activities. Able to phosphorylate inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) on both the carbon-3 and carbon-6 positions to synthesize inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) and inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4), and then to subsequently phosphorylate and convert either isomer of InsP4 to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Also converts (Ins(1,3,4,5,6)P5) to InsP6 (Probable). Also has a role in transcription regulation. The catalytic activity is required for PHO gene repression by phosphate and for NCR gene activation in response to nitrogen availability, indicating a role for inositol pyrophosphates in these controls. Inositol polyphosphates may be involved in the regulation of chromatin remodeling of transcription (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKLKLFPFQAAGHGQVLVSEDDKILIKPCIKSEVDFYKTCNDNITLYNWIPKNFGEWMPSSRDIEGINPIAESVAFSLTGKAIILENILYQMETPCVMDIKLGKQLWADDAPLEKRKRLDAVSRSTTSGSLGFRITGILSWDRTNNTYIKRSTAWGKTLTDSDVVEGLNDFFVSCSLSQKARLVESFLNLLKLFEVDLSESYIELKSSSILFVYDYSSLNPTYHCESNVVLKLIDLAHSRWTKNTIDHNTLIGVKNLIHCFAMLLKNE
The following text describes a protein:
Function:
Binds only to large DNA fragments. Recognizes a DNA fragment carrying 8 copies of box7 motif of the light-induced cab-E promoter of Nicotiana plumbaginifolia. Also recognizes the box7m1 motif.
Subcellular Localization:
Nucleus.
Sequence:
MYKAVSKRVTRSSGSGLKQTNVDNGGEISPTVDRVSEQGKSSEAGSHMPTDANGNGHLHHEIMDHGKGNEEQKPTPQTVKKDSNTNTKFSGSHRELVIGLPCRGQFEIHNRSRASTSSKRLGGGGERNVLFASHKRAQRSKEDAGPSSVVANSTPVGRPKKKNKTMNKGQVREDDEYTRIKKKLRYFLNRINYEQSLIDAYSLEGWKGSSLEKIRPEKELERATKEILRRKLKIRDLFQHLDTLCAEGSLPESLFDTDGEISSEDIFCAKCGSKDLSVDNDIILCDGFCDRGFHQYCLEPPLRKEDIPPDDEGWLCPGCDCKDDSLDLLNDSLGTKFSVSDSWEKIFPEAAAALVGGGQNLDCDLPSDDSDDEEYDPDCLNDNENDEDGSDDNEESENEDGSSDETEFTSASDEMIESFKEGKDIMKDVMALPSDDSEDDDYDPDAPTCDDDKESSNSDCTSDTEDLETSFKGDETNQQAEDTPLEDPGRQTSQLQGDAILESDVGLDDGPAGVSRRRNVERLDYKKLYDEEYDNVPTSSSDDDDWDKTARMGKEDSESEDEGDTVPLKQSSNAEDHTSKKLIRKSKRADKKDTLEMPQEGPGENGGSGEIEKSSSSACKQTDPKTQRLYISFQENQYPDKATKESLAKELQMTVKQVNNWFKHRRWSINSKPLVSEENVEKLKTGKEGECETSVAGSSKQTMETESVAEKPTNTGSRKRRRK
The following text describes a protein:
Function:
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Subcellular Localization:
Cytoplasm.
Sequence:
MTVTIVGAQLGDEGKGGVVDLFGDATDVVVRYQGGDNAGHTVVAGGEEYKLSLVPSGVVRGKTGVLGNGCVINPETLFEEVDALRERGLDPDVRLAKRAHVILPFHRELDGAEEAAKADSDSEIGTTGRGIGPTYEDKIGRRGVRVGDLLNEDALRDRLEYLVDAKRAIYEDVYGFDASETDGAFDIDAIHEQCLAYADRIRDEDLAVNAGDYLADRIADGDNVMLEGAQGTSLDIDHGNFPYVTSSNPTAGYAATGSGLGPTTVGQGEIVGIIKAYLSRVGSGPMPTELDGDQAEYIREEGGEYGTVTGRPRRVGWLDMPMLRHAARANGFTGIAINHLDVLAELDEVNVGHAYERDGERIHTLPATTEAWRDCDPVMKSFDGWSAFDPAVVADAGYSALPDNAQAYVEYVEAELDTPAYVLGVGPGREESVIRQNPFE
The following text describes a protein:
Function:
Water channel required to facilitate the transport of water across cell membrane.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala/Thr (NPA).
Sequence:
MMGVLKSAIGDMLMTFSWVVLSATFGIQTAAIISAGDFQAITWAPLVILTSLIFVYVSIFTVIFGSASFNPTGSAAFYVAGVPGDTLFSLAIRLPAQAIGAAGGALAIMEFIPEKYKHMIGGPSLQVDVHTGAIAETILSFGITFAVLLIILRGPRRLLAKTFLLALATISFVVAGSKYTGPAMNPAIAFGWAYMYSSHNTWDHIYVYWISSFVGALSAALLFRSIFPPPRPQKKKQKKA
The following text describes a protein:
Function:
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.
Sequence:
MEEIYAKFVSQKISKTRWRPLPPGSLQTAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHSISNQANVHQSVISSWLSTDPAKDRIEITSLLPSRSLSVNTLDVLGPCLVCGTDAEAIYVTRHLFS
The following text describes a protein:
Function:
Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures. Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI.
Sequence:
MASSEDLPETPPLLLSRRRRHSGTCSSGVSPNTTLQGLASLRCLPKHSLEREGLSCGGVSGGEASDKRRCGGLGRVQKKRSRGGTPVRHVIMPPSALDQLSRLNITYPMLFKLTNKNSDRMTHCGVLEFVADEGICYLPHWMMQNLLLEEGGLVQIESVNLQVATYSKFQPQSPDFLDITNPKAVLENALRNFACLTTGDVIAINYNEKIYELRVMETKPDKAVSIIECDMNVDFDAPLGYKEPERQAQHEEATEGEADPGDYVSDKGFRAFSGSGNRLDGKKKGVEANPFPIKPGDIRRGIPNYEFKIGKITFIRNSRPQVKKIEEDDPGQRFIAFSGEGQSLRKKGRKP
The following text describes a protein:
Function:
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MEKRALIAVVLSILFFYGYTALFSPPPKETPKPVATATQSQPAQQVTAAPVPVAVPAQPQPAVAARDVSVDTPAYSVTFSTQGGSIKRLDLKRYHETAGPGGKNVTLVSEDNPSNYTIGLRAPGFGLDQNAVFVPSADALTVGPGEKKQLSFTWVSPAGVTVTKTYNFSGDGYGLEIQYQVTNSGSARVSSPVQTVQTYPLVPKVKESRFETFGPATFAQDKLFEDKVKDLESGAKTHAAPLWSGFADKYFLSAVLAHEGSMAAATIRKTASGYLENTISSPELSLNPGEGRALTYRLFFGPKDIDVLKAQGNSLERAINLGWFAMLAKPLLHSLKFFHNYTGNYGIAIIIITVIIKVIFYPLTHSSYKSMKEMQKLQPKMQQLREKYKNDREAMNRAMMELYQTHKVNPVGGCLPMLVQIPVFFALYKALMFSIELRHAPFMLWITDLAAKDPYYVTPIIMGVTMVIQQKMTPSQMDPVQQKMMMALPVVFTFMFLNFPSGLVLYWLVNNVLTIIQQYYINRSISTAEAK
The following text describes a protein:
Function:
Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression.
Subcellular Localization:
Nucleus.
Sequence:
MMVAENLASYSEFADISKLQPTFHSDNGLYSMDDSAEFASLQPVDQGYDIYNQQYNNQSMNYVAEIDHNMLNPQDVLTTHTDPLLPSNGSFTTSYPVTTTYAAVNQQQDSTWCGYGTETCSSYFSDSDISLLEVSDDECPSPSSYCESPLNVVSQQISDVDSTNQSPGNELCMVQNAANGQTQQKTPTVRRNGRRKRRQPILSEFLYNALECPDKYGDKIRWVDRPRGIFEFISETKEILAEEWGLRKRNQKVMTYQKMSRALRLYINKDQVMNKISQKLRYAFRPDFMHSMLRSSANQIC
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MQRSQEQKRTVNGCIIAVAFIVLSITKLGKATNIEGGQNRPVFDGLCKLTKLARIDLTIPEEPNLKNQDFKDIIKLNMSLAPKAWKQVFWKTGEKNAWQDELPPKDQHGDDWEEYWLDWKEAIRSLYKADRTKAEDKITFESLPEDVKDTIRPRMINLASAAAALAKSPAAPAQLPSLKGKTLKQKLTEAVTGDGSKDVDTADYQSIYGASSGSDRQTACTTGSSGTRTNSLMGALSCVCAPETDSQADYVCTPAVAKADRWATGSPDTPSNTGKITKLCGKIPPRQLKENELRQAIEEIVALITTNSGTGYLGATKTGCTGAQGSGRCVKFTGYADNNGSIPPHTPWLTIPHSIATDLADRESRIVQAESTKAALKALAEQARKLSREGEIAKIIKGHLQTAHGQAAPGKTVNMEISDGECNKLTSNNTCKSPCKWNENTTDINKKCSLDPVKAIEQQAAQTAGTEEGAAGATTDKCGLAKTPEDFVLAKGDIPKDKKAF
The following text describes a protein:
Function:
Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDLDDWVTNSNECFFLNLYRPGTDSKQPRVFDDSFNPSFTYAVIDENETITGYKNPKIELDFRANDLKPRLKIQYDEKLELKDVPDITQVDLSPELFREHLPEPIPDDANVTSKDWKPPGVLMNSFSVEGKQYEIWKTPLADETARRIWKNMRILVLLFIEGATTEGLDDEETLDRWSLYLLYDVTPLPKATTTPYTLAGFSTSYRCWIFPTFDIMRATKQLPSPPPEASAEPQKYTPPRLTQDPETFLFNEKLDRLETSSRERISQFLILPPYQGQSLGAHLYDIIFEDLVKKPFIYEIPVEDPSEAFDAMRDYSDIVYLRKLPAFQSLSVASNLPPESLRKDSPIPRNQILGNGTDLEKLRHETKIVSRQFYRMIPSSNRNRARITRKAKSSNENDRKYYFWRLALKHRIYGQNADALDQMEVSEKVEKLEAAVDNQQEEYEERLEGLEKRAEFAAGQGSSAGPRTVPKRKRAIVDEEDEEWEDMDDASVASSKRMKS
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSDFLLQSSWFIPFYGLIGSILSLPWSFRLIKQTGPRPAAYFNVFMTLVSAIHGMVALSAIWQTPSEQIVFHWLQVADLDLTLAVEISPVSLGALSVVTGISFLVQIFGLGYMEKDWSLARFYGLLGFFEAALGGIALSDSLFLSYGLLEMLTLSTYLLVGFWYAQPLVVTAARDAFLTKRVGDIILLMGVVALSSYGQGLTFSQLDNWASTVPVTGITATLLGLSLIAGPTGKCAQFPLNLWLDEAMEGPNPAGIMRNSVVVSAGAYVLIKLQPVFTLSPIASKTLIVLGTLTVVMTSLIAIAQIDIKRTLSHSTSVYLGLVFIAVGLGQVDIAFLLLFAHAIAKALLFMSIGSIIFTTSGQNITEMGGLWNRMPVTTTSFVVGSAGLLAVFPLGMFWTWQKWFSGDWLVSWPLLALLIFVNLFSALNLTRVFRLVFLGKPQPKTRRAPEVPWPMAVPMVSLIIVTLLVPIAPLQWSFWLSATYPLGLTSPVTQWAMPLLMVAGITGILLGSLMPLRRNLSRSSRLPVRFLQDLFAYDVYLDKIYGATVVAAVAAIAKISTWFDRYVIDGIVNLVSLVTIFSGSALKYNVTGQSQFYLLTILVGVALLIWFSLSGQWMAIRQFWSSWLSLILP
The following text describes a protein:
Function:
Flavin-dependent oxidation of thiol-containing compounds. Probably required for the correct folding of disulfide-bonded proteins.
Sequence:
MTVNDKKRLAIIGGGPGGLAAARVFSQSLPNFEIEIFVKDYDIGGVWHYPEQKSDGRVMYDHLETNISKKLMQFSGFPFEENVPLYPSRRNIWEYLKAYYKTFIANKDAISIHFSTEVTYLKKKNSQWEITSKDELRTTKSDFDFVIVASGHYSVPKLPTNIAGLDLWFDNKGAFHSKDFKNCEFAREKVVIVVGNGSSGQDIANQLTTVAKKVYNSIKEPASNQLKAKLIETVQTIDSADWKNRSVTLSDGRVLQNIDYIIFATGYYYSFPFIEPSVRLEVLGEGVTGDKHSSVNLHNLWEHMIYVKDPTLSFILTPQLVIPFPLSELQAAIMVEVFCKSLPITTTFDSNACGTHNFPKGKDLEYYAELQELLNSIPRRVGHFEPVVWDDRLIDLRNSSYTDKEERNVLLAEHAQALKKKKAPYFLPAPHT
The following text describes a protein:
Function:
Interacts with cut9.
Sequence:
MESIIDAHCHPTDAPQELHLVANLSVGKLIVMGTRPTDQKYVEQLAKEYPGKVIPSFGIHPWFSYYLYDDLDKDLQSSETRKKKHYEKILTPIPDEDFINALPNPVPISEFLEDARRHLKQYPNALIGEIGLDKPFRLPVGPYDARSSLPQGPLSPFYVKMEHQCKVFEAQVRLAAEFQRAVSVHCVQTYALLYSSLAKFWDGRWIPSKTKIRKMKKEEYENSLAEERKHYPPKICLHSYSGSIEQISQFSAHKVPTEFYYSFSIGINSRYKNFIQTLKGVPDDKLLAESDHHSASQIDELVRQSLNVMSEAKSWTFEDTITKISSNSKAFLKVT
The following text describes a protein:
Function:
Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MPGNRQLKNRTAVDPPDGGWGWVVALAGSGILASTFGIIHSSGVFFVPWREQFVGASAAEVALVSTMVMGITNLAAPISSGLGGKFGFRPVIMAGGVLAAAGFCLSRFATHISHLYITVGCLVGFGSSLSVTNILVCLGRYFTTKRLRANSISTLGGSLGAFAFPPLFQLLIDEYGTKGALLIAGGIILHVVPLGALVRPIHLKAEATSITNSRKQPVFPDDNTLSVEIQDKGSHGCFYGCSIRKRFLSVLDVSLLKEPSLLIFLISVGFVASNRQASNIYLIPRAKFLGIDDYPAAFLMSIAGILGMFGRGIAGVLPEWERYRRIDQYGTVAVAMGFTMMLVPLAVSYGSMVAYSVVIGLLFGALIPLTITTVSDLVEIERLPSAMGLRMFVQGVATLAGPAVSGALRDVTGSYDATFLLGGACVLFGGLIPFSLHMRVFTQYKVKQTNKQTKEDIMDDTGMVDTAALNDNEPAPPDRPMIVTKETSL
The following text describes a protein:
Function:
Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair (By similarity).
Sequence:
MNEQQKQAISCGKGVNVVYSGAGTGKTTIITNRFAYLVNKEKVDPSRILAITFTKKAAKEMQFRILKLIDSSLAEKTNIYTFHSFCNKFLIQTLKKRFIIDDDISYFLKEFLADSKLDINLAKQIIDNFKNTFADFEINKLDQDERLISLCEHSLLNKDEEYSTLKTQLINAFISYEKNKILNNKLDFHDLLIKTCNLLSNDNDLLNQWSEQFQHILVDEFQDTNQIQYELIKMLVTKNKNLFLVGDNNQMIYRWRGAVNGIITALKHDFNVPKSNEFFINQNYRCDQNILAVANQILLKIMAYEKQVKTEKNLLFSTLNSDKKPVYFQAESVENQANWIFNKIKALNQTEKINFKDMAILFRKNRDITTMVELIEADGTIPLPKQKSYFNQLVKLQRVLIAISTRTNLDIKRALQALKIWSNDLKELWKQSDKTNLFDFLKWSELNQKNHSSKLKATGYFNLLIKLAEDQQINLLFTELFKKLKVDQTIENLLWKKLTEFQKDKTEFSLSEFITSLALEFDSIIENSSDTINLLTVHAAKGLEFEAVFIYGMNQGDFPLFLSQNQNDEQHLIDELKLFYVAITRAKRFLFITAVLQINNNSIKPSSFLNYINKSEYLDIATINYVLEQDDDFFDSTKKTDYTKKLRKESLDIIVGDLVTSRYFGKGVVVEVRDKEVLVAFKDTRYGMKWILKNHKSLTKALY
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKDDVIEMQGTVLESLPNAMFEVELESGHKIIAHISGKLRMNFIRILPGDKVTVELSPYDLTRGRITWRAK
The following text describes a protein:
Function:
Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (By similarity). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS. Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The C-terminus of the protein contains 3 potential CHEK1-binding motifs (CKB motifs). Potential phosphorylation sites within CKB motif 1 and CKB motif 2 are required for interaction with CHEK1 (By similarity); The acidic patch region is required for normal DNA replication. Interacts with the N-terminal segments and inhibits binding to DNA and PCNA. Mediates the interaction with the kinase CDC7 as well as some replisome factors and DNA polymerases.
Sequence:
MTGEVGSEVNLEVNDLKLLSQEAADSPVDSGQGSFETLEPLSERDSDEEIFVSKKPKSRKVLQDSDSEAEDRDDAPEKPTYDDSAEDTQENLHSGKSQSRSFPKALADSDESDMEETPSQESPETQEAPSLEPGHQTGHSVDFTTGRKLSKTLLREGAEGKAKSKRRLEKEERTMEKIRRLKKKETRCEESDADRPLNDSGCLLEDSDLFETGLEEENDSALEDEESLESIRAAVKNKVKNRKKKEPTLESEAFSLEDGNELSKGSARKERKAARLSKEALKKLHSETQRLVRESALNLPYHMPESKTIHDFFKRKPRPTCQGSAMALLKSCKYQSGHYKETVNPADAAGMGAEDSSRGSEQRTGAGIAAETNVLSEVSEEAGITAGSDEACGKDPVRRGELEIEETEKHSDDRPYSPGDRSMSQQESSIPRIEDNEGHQAGDLTESDPPALEGEELKTVEKTDAKEGMPEQKTQSAAAAAVAVVTAAAAPPEKVRRFTVDRLRQLGVDVSSQPRLGADEDSFVILDEPKTNRELEALKQRFWRHANPAASPRACQTVNVNIIVKDLGTNGKEELKAEVVPVTLAAEKLEGASHAKPGEKLQMLKAKLQEAMKLRRLEERQKRQALFKLDNEDGFEEEEEEEEMTDESEEDGEEETTEYLLGSEDTETKDEKETDKENTDTSSDIGKSVALCVPKPLSSDSTLLLFKDSSSKMGYFPTEEKSETDEYLAKQSDKLDEDDSSSLLTKESSHNSSFELIGSTIPSYQPCNRQIGRGASFLPTAGFRSPSPGLFRGSLISSASKSSGKLSEPSLPVEDSQDLYTASPEPKTLFLGAGDFQFCLEDDTQSQLLDADGFLNIRNHRHRYQAVKPQLPLASMDENAMDANMDELLDLCTGQFTSQPEEKCQPRKNDKKENMEELLNLCSGKFPTQDASPVAPLGLRSQEKESSTEDPMEEALALCSGSFPTDREEEGEEEEFGDFQLVSKENGFASDEDEHSDSNDEELALDLEDDEEELLKQSEKMKRQMRLKKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELESQIKKIHMKTMLDDDKRRLRLYQERYLADGDLHSDGPGRTRKFRWKHIDDTSQMDLFHRDSDDDQVEEQLDETEAKWRKERIEREQWLREQAQQGKIAADEEDIGDDSQFMMLAKKVTAKALQKNASHTVVVQESKSVLRNPFETIRPGGAHQLKTGSLLNQPKAVLQKLAALSDLNPSAPRNSRNFVFHTLSPTKAEAAKDSSKPQVRRRGLSSMMSPSPKRLKTNGSSPGPKRSIFRYLES
The following text describes a protein:
Function:
Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGDMLQSSSRVKLNRVALKDVIGVKIAPRRRKVQQPRADSKEEDKSVLEDSGCNKSPRDVLSYKKGAENGRASSIAAPGGKQEKRVDNNRTNSPGPAGLEGSMRRSNGCFDSVCQESKFSLRPQKNGSKRGLKRPSSDPVQGKAKSKKTTAKRSEERQLRTNPKVVLCDFAKNCSACRRGCGVILPKDLKNKAMRCFKQSGLQCWPGCVFHNKPEEQTCSAVLDGKNIRQVLNEEVGNRQMPLREATALLHSRLRNQVSTSAVASSSKHDSVGNRSTDTCSEGAGPVSDQTDSQAHKRINLGEISGFIRSRHPAAKGSNAALKLCKENGHQTELYGAQIPSEPICEKNHNDIPESFTCQRVNVYFRKAPYSCARTNIVWPFGKGHLSSHGPLASSSSKGVNFSVTDSVTEVTNQVGSSSSAALPETPLSKQEGGDGNAAVLSEGLTNSLHLHSNPTDDDDEDRTPSSLANGLETDSTCMTSSTLAFSPPSDASTHGDPNCLTSPLFLPFSTYLSEKAEDGLKADDTSMFRCEPSHLSTWGSPSSFTSENLDSSHSGESSLLFPQDKDQINNCPAGKPALNGNAVHLNSSSLCSFLKAGCIKADTNQYILPTLLSPVASPCRPAWRKSCERQSSSSSDEEEQAEDKQSSPECHRLQNQTEGHSSGNSTPGKARTSLWNVEDERDGKEDECDEDGQAVGATKEDASHSKTKSPALSPVQTKAPPCVGEEDPPTLDEITAYEHDILLVDVNQDDPDLFVDSPQLSLLRLGPVRASEAPKKTAPAAARLPFEVGGAPGKAVQSLTPVRRDLCFEGQDTAAEGDSRPWRPRCSSTTPPSTQNACPTTDEHSRRVVQFDVNNNHADGVFKRMQPIQTVGSSLSIPAQHPWARNAAGAANFWRQKSNSYCRQYFSESLTCGFKMCRFQHLPVEGDEKFCVETVMRFIKNPACLQKAGAVFSGYYQSSPPGVYFSMQVFLSLLWALLKAGMVSDIFSILRVTLAHNIVPSHEFLLDLFDFVREKSLTGFVLELLQLTVKMVNVGLELSLDCVNHMPLFQQTIHAHPPAAATPHQKSSPSAPLPDCLSLAHAVIEVELCTKQEDWKRMGKVFCSVCQSSHHPNQVERISGRIAIALLSESKDKLSLPFAAFVETVFQNEGEGSLVKNFVGRIGVSLMLRYHKTHQWLKGRAVVEIMSVSKVSYTTTKGLFGNEDSASRCSLVTVATELFLLSGSVEGALNTLRENAWFLSSSSWPCDPPDLENRTRVLKHLAEKTSHRDTLEVLSNLPGIKDPNTVDFMLSKKLPVDYTLLQTLLHKLGKQNLWLRAREVFRHSLKAGHYPGVVAPPGFMTLVIPCGLGEVEQVLTLEMLITVNASHILRLPESSSSTLSITLTRTNSCESNYLSAGSRLLTAACIPQPKLTIHYTAVNSSQDQVFKLDVSSARRWLRHNHLWASEVWAQ
The following text describes a protein:
Function:
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
Sequence:
MKLHEYQAKEVFADAGIPTPESALATSVDEAVEVADALDYPVAVKAQVHVGGRGKAGGIKLAENTAEAREAAESILGMDLKGYTVDRVLVEEAVDFTNELYVGVTMDRSEGAPVVMVSERGGVDIESVAEEAPEDIVREHVDPSFGLQAYQARNAVYDAGIEQDVAGDVAKIVQGVYDLWADSDATEVEINPVMVTSERDVVAADAVMKLDEDALFRQPAFADMEEDAAEDDLEAKANEYGFDYVRLDGNTGIIGNGAGLVMTTLDLVDYYGGQPANFLDIGGGAKADRVANALDMVFSDENVDSVVFNIFGGITRGDEVAKGINSALEQFDEIPTPVVVRLAGTNAAEGREILNDDLVTVEETLEGAVQRAVEYADEEDIQ
The following text describes a protein:
Function:
Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.
Sequence:
MTTTRQDTQWQQLTEHWQELADFGGIEALLGWDQSTFLPAGAAEDRARQQSLLAGLRHARATDAGYGKLLDAASSRSDLSPEQARMVQVARQDFEKATRIPAEFVREFSGHVGQSYSAWTEARPANDFGRMVPYLEKTLDLSLQAASYFPEFGDPLDYYINESDEGMTAEQVGQVFAELRAALVPLADAVIAAGAPRTDFLGRGFAQERQLAFGERVIRDYGYDFRRGRQDLTHHPFMTRLGGHDVRITTRVKEQDPTDALYSTLHEAGHALYEQGVDAAFLGTPLGGGVSAGVHESQSRLWENLVGRSRAFWAAYFGDWRDTFPEQLAGVTEEEMYRAVNTVSRSLIRTDADELTYNLHVITRFELEREMLAGKLAVRDLADAWHAAYEQNLGLRAPSDVDGALQDVHWYFGPIGGSFQGYTIGNVLSAQFYAAAEAANPGLEADFARKDFSRLHGWLRENVYRHGRRWTPGELIERATGQALTAGPYLKYLRGKYGELYGV