lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in septation.
Sequence:
MGVVYGSQQNLSEYFYSSVNMAEVPDTFEENRGHSFEGVTLQRRHVKGMKSYGSDITPRRPKQLGLPKEVNTSECIDQGSWRKPSAFESLRSYSRKFSKRIFSFIGVESKSTVQRNASGADSTSLSHFTANEINKGNCKKTALSNEFNSANKGSKASGVGAELPSVNGFIEGELHDDNETDSFRINELAKQIQETSLGATTQEDESSDGICWDELSTTSPESSKVSEPIIQDNTQTTHINNDSSDIRFSSRCDLFADDADSDWEQDFNVKFDSPLIIPETVNSAGHTVREQLFEVKEFTRSIKDLKDLYEKANSKDIYDKDSEILGEAKAILRLADPANYSDLKDEDAQNILSKYKVKLEGDSSLDFDASMLPGLNDHVHYLMSQLQLLLH
The following text describes a protein:
Function:
This protein binds directly to 23S ribosomal RNA.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MEVALLSFSSSLSPLCHQRISTLTPKTSNSPNYPRLPVIRSAVSRNKKEETVEAVKSHLENCHLLAAINYKGLTVKQFQDLRRTLPDTTKLIVAKNTLVFKAIEGTKWEALKPCMKGMNAWLFVQTDEIPSAIKPYRSFQKERKLENNDFAGAVFEGKFYAPDNFKVLETMPTRAEVYAKMLGALQSPAINLVTTLQAPAREVIMVLMAYIKKLEDESNA
The following text describes a protein:
Function:
May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.
Subcellular Localization:
Nucleus.
Sequence:
MEAYEQVQKGPLKLKGVAELGVTKRKKKKKDKDKAKMLEAMGTSKKNEEEKRRCLDKRTPAQAAFEKMQEKRQMERILKKASKTHKQRVEDFNRHLDTLTEHYDIPKVSWTK
The following text describes a protein:
Function:
TobZ is involved in the biosynthesis of the 2-deoxystreptamine-containing aminoglycoside antibiotics such as nebramycin 5 and 6-O-carbamoylkanamycin. Catalyzes the hydrolysis of carbamoyl phosphate and its subsequent adenylation by ATP to yield O-carbamoyladenylate. Then it catalyzes the transfer of the carbamoyl moiety from O-carbamoyladenylate to the tobramycin 6-hydroxy group to yield nebramycin 5'. It catalyzes the same reaction with kanamycin A. These reactions are considerably slower in the presence of deoxy-ATP.
Miscellaneous:
MISCELLANEOUS: It seems that TobZ plays a solely passive role in the adenylation reaction: all functional groups appear to be provided by the substrates themselves, representing an extreme form of substrate-assisted catalysis. The role of the iron in catalysis remains unclear.
Domain:
Consists of two major domains: the N-terminal domain (Kae1-like) is involved in the transfer of carbamoyl from O-carbamoyladenylate to tobramycin or kanamycin; the C-terminal domain (YrdC-like) is involved in the hydrolysis of carbamoyl phosphate and its subsequent adenylation by ATP.
Sequence:
MRVLGLNGWPRDFHDASAALLVDGRIAAFAEEERFTRKKHGYNTAPVQAAAFCLAQAGLTVDDLDAVAFGWDLPAMYRERLGGWPHSDSEALDILLPRDVFPRRTDPPLHFVQHHLAHAASAYYFSGEDRGAVLIVDGQGEEECVTLAHAEGGKITVLDTVPGAWSLGFFYEHVSEYTGLGGDNPGKLMGLAAHGTTVDETLSAFAFDSDGYRLNLIDPQARDPEDWDEYSVTERAWFAHLERIYRLPPNEFVRRYDPAKGRVVRDTRRDPYEYRDLAATAQAALERAVFGLADSVLARTGERTLFVAGGVGLNATMNGKLLTRSTVDKMFVPPVASDIGVSLGAAAAVAVELGDRIAPMGDTAAWGPEFSPDQVRAALDRTGLAYREPANLEREVAALIASGKVVGWAQGRGEVGPRALGQRSLLGSAHSPTMRDHINLRVKDREWWRPFAPSMLRSVSDQVLEVDADFPYMIMTTKVRAAYAERLPSVVHEDWSTRPQTVTEASNPRYHRMLTELGDLVGDPVCLNTSFNDRGEPIVSSPADALLTFSRLPIDALAVGPYLVTKDLRH
The following text describes a protein:
Function:
Interferon-stimulated protein that plays a role in several biological processes including cell differentiation, autophagy and innate immunity. Cooperates with CGAS to sense dsDNA and activates the STING-dependent type I IFN pathway. Mechanistically, gets acetylated upon bacterial infection and then translocates from nucleus into cytoplasm to recruit STING for activation of TBK1-dependent IRF3 nuclear translocation and IFN-beta release. Inhibits the transcription of ribosomal RNA. May inhibit DNA binding by UBTF. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Acts as a coactivator of RUNX2 during osteogenesis. May be involved in macrophage differentiation. Enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Nuclear in proliferating cells, translocates to cytosol during cell differentiation or bacterial infection.
Domain:
The 2 HIN-200 domains are able to interact with RUNX2.
Sequence:
MVNEYKRIVLLRGLECINKHYFSLFKSLLARDLNLERDNQEQYTTIQIANMMEEKFPADSGLGKLIAFCEEVPALRKRAEILKKERSEVTGETSLEKNGQEAGPATPTSTTSHMLASERGETSATQEETSTAQAGTSTAQARTSTAQAGTSTAQKRKIMREEETGVKKSKAAKEPDQPPCCEEPTARCQSPILHSSSSASSNIPSAKNQKSQPQNQNIPRGAVLHSEPLTVMVLTATDPFEYESPEHEVKNMLHATVATVSQYFHVKVFNINLKEKFTKKNFIIISNYFESKGILEINETSSVLEAAPDQMIEVPNSIIRNANASPKICDIQKGTSGAVFYGVFTLHKKTVNRKNTIYEIKDGSGSIEVVGSGKWHNINCKEGDKLHLFCFHLKTIDRQPKLVCGEHSFIKISKRGNVPKEPAKEEDHHHGPKQVMVLKVTEPFTYDLKEDKRMFHATVATETEFFRVKVFDTALKSKFIPRNIIAISDYFGCNGFLEIYRASCVSDVNVNPTMVISNTLRQRANATPKISYLFSQARGTFVSGEYLVNKKTERNKFIYYGIGDDTGKMEVVVYGRLTNVRCEPGSKLRLVCFELTSTEDGWQLRSVRHSYMQVINARK
The following text describes a protein:
Function:
Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MAGQLKNPKKQFQLNPNWAQLREQLKSNGFKKPSEASETEIPNSILGKRKSRPGDDSCDARPNPLIPTSSDSSVTDVIAMDCEMVGVSSNKSALGRVTLVNKWGNVIYDEFVRPVERVVDFRTKISGIRPQHLKKAKDFRIVQKEVAELIKGRILVGHALRNDFKALLLNHPKQDIRDTSEFQHFLSREGRSRALRHLATEVLGVEIQNGEHCPIEDARAAMMLYLKRRKEWEKSVKDFVRLKEKQKKRKPKKKTGVLRRPASE
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSSRIAFQTQLASIMEVLANAAVAEICKLVDDDYAVINLQMSQCQRENKALKRKLHVLELKMARGFAERRISSLNRANRVQVSTALSDKYRNQSNDGLYGNQFNTGLWRGGRTDSTPQEAVNESDSGAGDAVLPDAETLLIKDEMFEDHQTQQRLFIRDDGITETSQTGEPGFGDVQKDDDQVSGMQHTNLEQGKVEYEEPETIVIKEDLNDQWEISQAQTITVQDVESNKDICSKRLSTSPTKPTVAPGTEKPIELEFSHFSKSGQKSWGQKSDTSSSTGLQMNLQGTAESSPSSSQQHQFQNFAARPNKSLTTIKITAVSGSEQVHKGIGKSRNSPTNQPSLTAEKTAIETADCLLIDKPAEHKTSFTHWPTQPSHSYSDSNQDEDCVLVQSETVTSIRNSKSGQDGSSFTQTHPAAERPLREEERWNQAGIFKQSQTDVSGHIGRPEAIQKDTPNRSSASYFTVIPQTMSNLTQPGASLAGPQLPKRMEKGRRRSYVCKYCGKAFPGLSNVVAHQRVHTGERPFRCDICGKLFAEAGNLKKHQRVHTGEKPFTCPRCGKQFAWICNLKTHQQSASCGAV
The following text describes a protein:
Function:
The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRHAFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETPDKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHIHWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVEDEVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLTGAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAVSFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFYTFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAPVLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQGDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDALILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRGDVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFPNIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIRVLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN
The following text describes a protein:
Function:
Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.
Subcellular Localization:
Secreted.
Sequence:
GIFLDKLKNFAKGVAQSLLNKASCKLSGQC
The following text describes a protein:
Function:
Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
Miscellaneous:
MISCELLANEOUS: Present with 2020 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKYLLYMVQVHLNFRRAELESLADLYNLSIDFSQYDANSPFFIVELENDQQAKDWIKRSILTRGIYEYWGQGTTLDELHKDIQRQSNFEQDLQLKFKHSTFKFEFECYKGNSKAKRVEQIETFRYLGFEGKIDMKHPQEVFTVIEEYTPISENVGGKTPTRIYFGRQVQMSNRSAMEKYDLKKRPYKGTTSFEAELSLVSANIAQVKPGTIMYDPFAGTGSFLVAGGHFGSLVIGSDIDGRMIRGKGAQVNISANFKKYGESSQFLDVLTMDFTNNALRNNLVIDTILCDPPYGIRESIKVLGAKDPERFLGKEDMEIDGEKAYLRRDYIPTKKPYALDSLLDDLLQYSSERLPIGGRLAFWMPTANDANIETIVPMHENLELKYNCVQEFNKWSRRLLVYINRGSTFNGSSNHGIKRSKDNFRERYFNNFN
The following text describes a protein:
Function:
ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, used for the elongation of fatty acids and biosynthesis of isoprenoids, flavonoids and malonated derivatives. May supply substrate to the cytosolic acetyl-CoA carboxylase, which generates the malonyl-CoA used for the synthesis of a multitude of compounds, including very long chain fatty acids and flavonoids. Required for normal growth and development and elongation of C18 fatty acids to C20 to C24 fatty acids in seeds. In contrast to all known animal ACL enzymes having a homomeric structure, plant ACLs are composed of alpha and beta chains (By similarity).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MARKKIREYDSKRLLKEHLKRLANIDLQIRSAQVTESTDFTELTNQESWLSSTKLVVKPDMLFGKRGKSGLVALKLDLAEVADFVKARLGTEVEMEGCKAPITTFIVEPFVPHDQEYYLSIVSDRLGCTISFSECGGIEIEENWDKVKTIFLPAEKSMTLEVCAPLIATLPLEVRAKIGNFIMGAFAVFQDLDFSFMEMNPFTLVDGEPFPLDMRGELDDTAAFKNFNKWGDIEFPLPFGRVLSSTENFIHGLDEKTSASLKFTVLNPKGRIWTMVAGGGASVIYADTVGDLGYASELGNYAEYSGAPNEEEVLQYARVVIDCATTDPDGRKRALLIGGGIANFTDVAATFNGIIRALREKETRLKASRMHIYVRRGGPNYQTGLARMRALGEELGVPLEVYGPEATMTGICKRAIDCIMLPDA
The following text describes a protein:
Function:
Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity).
Sequence:
MSDMFRKSVLNKLPHLPPTRAPWADESEPIEEIDEEDEQLDGIGEFKPATMGPSKHDTQDYSPLSASTFFAQAAEVQPPSTPCTFRVYLTPPNLSIASANAGTPPGPSGLRTQQQTNRHGTYLVCHHGGGASGLGFAPLAREVKAKGNGEMGVLAFDCRGHGKTSTSDPNLELDLSHDTLLSDFMAIIEMMFPDPKESPSLILLGHSMGAAPVVSAAPELQKKGYTIPGVVVLDVVEGTAVESLPLMKSVLSKRPESFRSVIDAIYWHVTSNSIRNVESARVSVPHIIVPAPSSSSSDPSANPGGKQVWRTNLVGTEPYWEGWYKGLSQRFLRTKCARLLVLAGQERLDRELMVGQMQGKFQLEVMSDVGHYLHEDNPAGLAATLITFWHRNTRVLVLPPKIGAPGPGARGGPVEVKQVGQQ
The following text describes a protein:
Function:
Serine/threonine protein kinase required for spermatid development and male fertility.
Subcellular Localization:
Cell projection, cilium, flagellum. Note=Localizes to the sperm flagellum in mature sperm.
Sequence:
MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEPDMILRPSIEEVSWHPWLAST
The following text describes a protein:
Function:
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Subcellular Localization:
Cytoplasm.
Sequence:
MIDTLAFVHPDAKIGKNVTIGPWSYVGAGVEIGDDCWLSSHVVVKGPTVIGKGNRIFQFASVGEECQDKKYAGEPTRLIIGDNNVIREHVTIHRGTVQDNSETRIGSNNLFMNYVHIAHDCVVGNNVIMANNASIAGHVHVGDWAILGGMTGVHQFVHIGAHAFTAGCSLLLQDVPPFVMAAGQPAIPRGLNSEGMKRRGFSKESQLAVRRAYKTLYRSSLTVEEAVEALAEDAQNDAQVKLLVEFVKSSGRGIIR
The following text describes a protein:
Function:
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria.
Subcellular Localization:
Nucleus.
Sequence:
MYSTFSANFDTTIDASRDRSATPVTAPRPKRNQVARACDWCRLNRVRCDDKQPCQNCQNRGGSCSNTKPQEATSLPAANREMQRLRNKVKDLQDQIAKLKEGAEIQAQTGFATPPLSDAAHTSFDFAELTNTTEGWQGLQQTGQIHYGPLSSSYFVSRISRYLSQALNEPIEDAKLEACMARFHYIAPSHQPSRWDASPASQADQPQDGTEEAEDLTRSQEEHFLNLLWQSFHCVYPILDEREFQQYYESLWSSSPDGMSTRKPSALVDVLLAVCMQYSSTFFVSDDNQQGDTDSEWQAKHANLASRTYYQRAQRLLQSELENPTIMVVQSHIYSIVYLYNTSLLNTAHINLGATLRIAHALRLHIRPLDGTSPEQQELQRRIWWALYRIDSQLSMTLGRPPLIQLSHVSCGLPGDDREHARLSGTVLLTNHEDISWLSFHVQCTKLIFLVQGVQTAFNRKCSQLLNGDKVKDLYEDPRLLETLAEFLGQEMTAIHNWVQNVPQSLCNPRKGGSDPFSTNRDALNLSAYSPLWLQRQRLLLELHYHHLVISTLRPFIRFPPVSSSMTPLTDGYNISCLNHAMAITSILNQVLSETDLLRGWSPIFQYQWDAILCTLGFVLANSVCPPTPSARKSLQTAIRTLDLVSDHFLAAKNAAQVVREVSCQADRLVKNVQQGLTRRQAPRASQALSTRAQNPRQASNQTSFVAPAQPGVRSNSLKRALPPTTLEVSQHQPMPNFEARMQLMDMMPIGSLSELSPSLGTTESMSMPSVTSADMVIGTEAQWLHASAMILDSWTTNS
The following text describes a protein:
Function:
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing. During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation. Essential for female reproduction because of a critical role in ovarian follicle development. Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity).
Sequence:
MQRLVVWDPVCLPLPPPPPAFKSMEVANFYYEADCLAAAYGGKAAPAAPPADRPGPRPPTGELGSIGEHERAIDFSPYLEPLGAPQAPAPTTASDTFEAAPSAPAPVPASSGQHHDFLSDLFSDDYGGKNCKKAAEYGYVSLGRLGAAKGALHPGCFAPLHPPPPPPPPPAELKAEPGFEPADCKRKEEAGAPGGGAAGMAAGFPYALRAYLGYQAVPSGSSGSLSTSSSSSPPGTPSPADAKATPAAAACYAGAAPAPSQVKSKAKKTVDKHSDEYKIRRERNNIAVRKSRDKAKMRNLETQHKVLELTGENERLQKKVEQLSREVSTLRNLFKTLPEPLLASSGHC
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds the 7SL RNA in presence of srp68 (By similarity). This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participates in the elongation arrest function (By similarity).
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Domain:
The C-terminus is essential for the interaction with the srp68/7SL RNA complex.
Sequence:
MSKDTTVSLEQLFKELDEYIINSQFKKAIRVCNKILSVNGNDSEAFQCKVICLMQLSNFTEAIECFKKPEQIQSMQFEYSYCLYSTAKYQEALTQLEKQSSKETKSLELEAQIYYKLENYQKTISIYESLLSKPGYSDSIEFITNLCAVYLDAGKFNECQELLNKNKSQQTKTHELAFNSACLAISKNDTKTAETQLKLAKKICTDSLKKDGFSEEEIKEEQTSIDVQLGYVQQICGNLEKSLEQYQNVLEQQVGDSATLVATNNSISVRSILQSDQWSTQPKEYTHAMDSLKSLLTEAESTRLNSKQKKVINYNLCLLLVQLKKVSQCEELIKTLKSKYGQQQQQVDTSFVEDLDIIQVSLLIKEKKFKDAEKLLLKNNTTTGSIKSQLLLAQIYLLDNNNVAKALNVLEKLDSSVSLRPGIVATKVALYEKSGDLEKAVNSLDDLISIFDKQKKSEKDEEIYVNLLKASGNFKLKHHKYREASDMFDRVLKINPNDLIALPSYIVATSHFDPSLSQKYEGKLPNIKFESKIDIDLIEKYGLTFEKKLNLNEDSNSSSPTTTTTTTTKSTKPTATEVVKIKKSKKKLPKVMKPNYVPDPGRWLPKWQRANAKAARSKKNKDIIKGPQGIASASQTASLFVQESKNTNTNNNNTQSSKSEKPRNIHKKKSKK
The following text describes a protein:
Function:
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
Sequence:
MSAAAGPKVAFFASPAFALPVLEALRAEFEVVLVVAQPDKPVGRGLKLTPPPVAARAAELGLPLAQPHKLRGNADFAAQLRDSGADVAVTCAYGKILPAGVLEIPRFGFLNTHTSLLPRYRGAAPIQWALIRGETVTGTTIMQTDEGMDTGPVLLQEELPIRPEWTSVELSAALSEQAAALIVRALRTLETLTPQPQDEAQATHAPLLVKEDGFVRWADPAQAVLDRFRGVAAWPQTTAFFGGKRLKLAGLTLGQGKGQPGKVLQVGAGGLTVACGEGAVCIATVQPEAKKAQPAQVWAQGQNVEQGARFDLWEPPQG
The following text describes a protein:
Function:
Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development.
Subcellular Localization:
Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein. Lysosome membrane.
Sequence:
MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNVYHHGREGNRMNGSRTLTHSISDGQLQGGQSNNELFQQEPQTAPAQVPQGFNVFGMSSTSGASNSAPHLGFYLGSKGTSNLSQQTPRFNPIMVTLAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPSGTTRQAQQHSGWVSQFNPLNPQQVYQPSQPGPWTPYPASSPMSHTSAQQPNQQGHQTSHVYMPISSPTTPQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNSSSKLRSSGPRTSSSSSSVNSQTLNRNQPTVYIAASPPNTDEVMSRSQPKVYISANTAPGDEQIMRNQPTLFISTNSGASSASRNMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISEARKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSTIKTPKTQDTEDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF
The following text describes a protein:
Function:
Catalyzes condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) to synthesize N-acetylneuraminate-9-phosphate (Neu5Ac-9-P). Neu5Ac-9-P is the phosphorylated forms of sialic acid N-acetylneuraminic acid (Neu5Ac). In contrast with human ortholog, has no detectable activity towards D-mannose 6-phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MPLELELCPGRWVGGKHPCFIIAEIGQNHQGDIDVAKRMIRTAKECGADCAKFQKSELEFKFNRKALERPYTSKHSWGKTYGEHKRHLEFSHDQYKELQSYAQEIGIFFTASGMDEMAVEFLHELNVPFFKVGSGDTNNFPYLEKTAKKGRPMVISSGMQSMDTMKQVYQIVKPLNPNFCFLQCTSAYPLQPEDANLRVISEYQKLFPDIPIGYSGHETGIAISVAAVALGAKVLERHITLDKTWKGSDHSASLEPGELAELVRSVRLVERALGSPTKQLLPCEMACNEKLGKSVVAKVKIPAGTTLTLDMLTVKVGEPKGYPPEDIFNLAGKKVLVTIEEDDTVMEESVESHSKKIKA
The following text describes a protein:
Function:
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon; RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSLKKKTFKQRIRKNDMKQRHQIGFGLRKRMGAARRIRNRYDSVDDGTRPMEMIVSEIAEGTAVPSQEAVLDPRSLTDLLLRPAESPVSNNSASASANVATTSCAVASKSNGCSSALWKRGSSKSSALLTSVPLASEKVLPSLPLAPDDPLALPDTRVFEEEERQQRLAREAAARQNENKNLYRHSGQPYLFWERVGLHPALLQALRDLHFTHPTPVQEEVLPNVLASGDEGLARQRSSEADKKSKKHKRAGGAADSAGHDVVVSAETGSGKTLVFALPILQDLLTTLDTERVSAVTPTSSAEAVHEKATGQASSDAAVARAELKAKRQKRIMHSLIISPTRELALQIDAAIRQLTKFAPQVVVGCVVGGMAQERQQRVLNRHPHILICTPGRLWDLVQKNEGCYLGHSASRRLHYVVLDEADKMLQSGRFAELQTLLERIHCEVLPAGFAQDREEGAEPGEIAVESGRWDPDTESFIPFDKEEAGATKPKVKKLVAETVTEAGGAPVETMKGKKRAREAMEAAAEDVSSTSKTKKAKKVTADVTPAKSRKTAKTSAKQAAGLKEEEDEEAADEEETASKYGNINTETEHGGARHRKDEPQPIPMPPEPAAGHRVITYVTSATLSLQTNYERRDFSARKSIIRTSNADVLTKVLQQLEIKLSNARVFSLAESANVAARINETYLRCPDNSKDLYLYYFLKTYHDDRAIVFVNAISMLRRLVKLLEVLGIAVVGLHASMQQRQRLKFIDKFKEGKIHVLVATDVASRGLDIDGLKYVVHYQVPRTTEAYIHRCGRTARCGGTGLSVLLVNAQEHMSFRKLMESLGRKESEVETFAMQATIVHQLHSHLRIAWQIDKLQKEIGKSRANNQWVNRMTKEADLETDDMFDDTADAENREKQKAIRILQRELQLLGRKFTGQYGGKGAFRTSAYALGAKQAEQHLKERADRQTIRVASKKKKFAADGKK
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway. May cleave double-stranded RNA to produce short 21-24 nucleotides (nt) RNAs which target the selective destruction of complementary RNAs.
Subcellular Localization:
Nucleus.
Sequence:
MGDISTAAASAGKREPQPKDPRTIARKYQLDLCKRALEENIIVYLGTGCGKTHIAVLLIYELGHLIRKPRRDVCIFLAPTVPLVLQQATVIANSTNFRVQSYYGDGKTPRDHENWETEMAESEVLVMTPQILLHSLQHCFIKMDSIALLIFDECHHAQVHKRHPYAQIMKGFYNNDMVKPPRIFGMTASPVMGKGGSNKLNYTKCINSLEELLHAKVCSVDNAELESVLAFPDMEVHTYVPLSQSNLTVTYNKELDRSKLESERILRESLYDFKDSQKKLKSLGRLHGNLVFCLQELGSFGALQAAKAFLLSFDGDVLDRKESDMNDNSTRFKHHYLNKAISVLSSNILDGTHDDSFDLEMVEPFFSNKIMVLINILSRYRLEENMKCIVFVKRITVARAIAHILQNLKGLDLWKCEFLVGRHSGPKNMSRQKMDAIVENFSSGEVNLLIATSVGEEGLDIQTCCLVVRFDLPETVASFIQSRGRARMTNSKYVVLLERGNHSEEKLLNDYIDGEGIMNGEIDLRTSNDVFDHLEEKSYQVEKTGASISTACSVSLLHRYCYNLPKDMFFNPSPAFIYIDDTEGIICRVILPPNAAFRQVDGQPCQSNDEAKRDACLEALVKLYELGALTDFLLPGSGSRKNKASTTNGSASNSHDDESLREELHEMLIPTILKPSTCKLDCPLNLHFYYIQFFPIPADRHYRIFGLFVINPLPMEAEKLEVDLHLARGRIVKAGMKHLGTISFDEEQMMLARNFQEMFLKVLLDRSEFTVSHVMLLGNSETLQFNSTFYLLLPIKQELYGDIFMIDWPTVKRCLSSPVFKDPTGVSAHGSYLPDESLRLLDNMYSKTDVVGSLIFAPHIKTFFVIDVILNELNARSEYDGATYEDHYKERFGIKLSHPEQPLLHAKQLFNLHNLLHDRLRETTEGGRELMEHFVELPPELCSLKIIGFSKDMCSSLSLLPSLMCRLENLLVAIELKDVMLSSFSEASQISASGILEALTTERCLERISLERFEVLGDAFLKYVVGRHNFLTYEGLDEGQLTSRRSAIVNNSHLYELSIKRNLQVYIRDQHFEPTQFIALGRPCKVVCSADTEVNIHTDSRENCNLRCTKSHHWLHRKTIADAVESLVGAFLVEGGFKAAFAFLHWVGIDVDFKDSSLYRVLDASSINLSLTNHTDVDELEELIGYNFKHKGLILEAFVHPSFNKHSGGCYQKLEFLGDAVLEYLITSYLYSAYPDLKPGQITDLKSLAVSNNSLAYVAVQKGIHKYLIKDSNYLSTAVNKFENYIRLPNSEKDLVEEPACPKVLGDIVESCVAAVLLDSGFNLNYVWTLVLMLLEPVLSFSDMHMNPMREIRELCQCHELELGLPEPMKADGEYHVKVEVNINSQVISSAAANRNSKVARKFAAQETLSKLKNYGYTHKNKSLEEILRDARKKEPELLGYNEEPIKVEADISAEMNNLKIGKERDANISFQNTEISIRGTLRTSSQRTAGNTMFSKDDVSIERNNQLKVAKQNACLPKGTTQKNIRKEYHGDMVNKTAKSFLFEVCAVSYWKPPEFELCKEEGPSHLRRFTYKVTVQIRGPSETLLECYSDAQLQKKAAQEHAAQGALWYLRQHGYLPKDEVRV
The following text describes a protein:
Function:
Orphan nuclear receptor (Probable). Plays a role in morphogenesis and elongation during embryonic and larval development. Plays a role in muscle formation and motility.
Subcellular Localization:
Nucleus.
Sequence:
MLVPPVSMIMYHELPSIKNKKREKIPEGTLCVVCSDFASGIHYSVASCNGCKTFFRRALVNKQTFTCQFSGDCVVGKSVRCVCRSCRLKKCFDMGMDPKAIQHDRDKIRYTKALKKKREEEKRLKEMVIKEDIGSPQSIASDTYINTSTPSSSTMINILENDHHSYDPEAQNDVKAVIEDLLRLESRVKSLRNSYRFESQVSATSCMYSSCLLDDITYMAENTHENEGTIEPFECSVEKLREWFVRDLSLMLEWGKCLPIMERLLLNDKLALMKAFAPIFPLIQLAFYTRNEFECDIVIKLEPDCTPKPIPERLNYPDGSFIEKGNKPANTWEEMHTMLIDGCYKMMRQLKIKESTFVLYKMLLFHNPDADGLSSLGKKTIENERMRLLTQLFSYLSTERGKEAQTIFSNLLMMSATLSKTASFIKRVFDFNHIFNRTNDLIDQLIIVGL
The following text describes a protein:
Function:
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Sequence:
MADIPRSVLNKLVFFTACMILLPLTCFFTAQMFTDNTLISGGLAAFVANVVLIGYVIVAFLEDVPVDEKKEQ
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. May bind to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. Can determine the ectodermal cell fate and promote the earliest step of neural and neural crest development. Involved in establishing left-right asymmetry in the embryo (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Domain:
The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation. The zinc fingers and the N-terminus are independently important for establishing the L/R axis (By similarity).
Sequence:
MTMLLDGGPQFPTLGVGGFGTARHHEMSNRDAGMGLNPFTEPSHAAAFKLSPASHDLSSSQSSAFTPQASGYANSLGHHAGQVPSYGGAAFNSTRDFLFRNRNSGIADSTSAGGQHGLFASHGPPGIGEPPGHLIFPGLHEQSSSHTSSNGHVVNGQMHLGLRGDIFGRPDPYRAVPSPRTDHYAAAQFHNYNHMNMSMNVAAHHGPGAFFRYMRQPIKQELSCKWLEESPMNRPQKTCDRTFSSMHELVTHMTMEHVGGPEQTNHICYWEECPRGGKSFKAKYKLVNHIRVHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYICKVCDKSYTHPSSLRKHMKVHESQGSDSSPAASSGYESATPPAMVSANSEEPSKNSSATHQTNNSSHNTGLLPPNFNEWYV