lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus.
Sequence:
MVRVKHRYIIFKIIPEDPNAADFGDGYSIPKSLAKPFIDMFGDFGAGNVLTSVNLVVWQPEKFTGVLRVARDWATNYVKMLDTIKEIHGIKANIKVPHISGTIDQAQRWIANNQETLN
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Sequence:
MPSAPAATPSPGGRGRARFDFSAKPAAMERSNSKRPAAHSQGSAVKSSPGGSAKKQAKLFSFFGKATTPSTKPKVQPGKASLTSDATSLSDKFQQSPTAPNSGSQASPSSTLASPPPSIQTTVVKSVKTKLDVSPDQAVIAPTQTPARPSMSTEPSARATKTQRSAVARSSSPPLSQRARAAARRSERSSPKRAREVLIELEESSSDESEEPLSEDEYCPDDEELEAVKREESEDLDQDSESEVPDESDGVLESEPESDGERRSAAKTRRKRAPSSASKTQKAIKPFSPTSAHSELDNFAARTSRTPPKTVAPKSNGPLSQSEAGAGATSNAGRFRFLADLRDSHRRKPSDPNYDPTTLHIPTQEFEKLSPFEKQYWTIKKDNFDTILFFKKGKFYELYEQDAFIANREFQWKITERVNMSMAGVPESTMIDWATRFLALGFKVARADERESALAMQMRQRKEAKGGQPNKKLPKIIERKLTTIYTKGTLMGDFVVGDLSSYIMAIKESDDGDAYGIVFADTATAEFYFCNITNDQRKIQLETILVQIMPKEFVLCRNQCSKELLALIKTNVPHADLSWLDEHHEGWRPDFVKSMVDSDNYNLRQTRLEELISADLTWAAFGGLVSYFQKLLVDKHVLPQGRFETYDPVKHGAMLVMDGQTLQNLEILTNNVDRTSKGSLFELLCHTVTPFGKRLFRDEVAILMKSLPDLERLLARVHAGSCKLKDFLELLDAFARLNDTAHRWVADNRLNQVTAVRLQQLLTPGKALPRLEEPLERIKASFDHEKALADGIMEPTMGALSDFDAATTTLDTLTKELDVHLQKAKNRLKSNKVPMADTKGVPSDWRLLSSTKNFKRYHSPEVLARLQPLLEAEETQRQIRSQFYATTLCKMDSYAEVFSAAVATWAEVDCLLSLYRATHVFGDPCCRPVFVNAADAGQSSGASMQIESSRHPCMSETGIVTDFIPNDIRIGGDAAPVVLLTGPNMGGKSTLLRQTCITVIMAQLGCWVPAARCVLSPVDRIFTRIGANDNIMAGRCRTLFATHYHMLTEEFQPEPLVANFNMACIVDEGSKRDVTFLYKLVQGVCSKSYGMNVAAMAGLSDAVIQAAEHKARECEKSAAFRSCGLRQKTQV
The following text describes a protein:
Function:
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
Subcellular Localization:
Nucleus, PML body.
Sequence:
MSGRLSEGAIGLIMQQGDTTIKPILQVINIRPIATGNSPPRYRMLMSDGLNTVSSFMLATQLNVLVEEERLSSNCICQVNRFIVNTLKFGRKVVILMDLEVLQSADEVGGKIGNPVPYNEGQGQQQAAPAPSPATNPVATKPQQQNGSSGLGSTATKSFGGSKTFGKVGNANLSTPGGSQLKVVPIASLNPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSIEMVDESGEIRATAFNDQVDKFFPLIDVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVVLCEDAHHLPTVQFDFTVIGDLENKAKDSLVDIIGVCKSYEDASKVVVKSSNREVSKRNVHLMDTSGKVVTTTLWGEDADRFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTILVNPDIPEAFKLRGWFDSEGQALEVVSISDARGGGMGGSNTNWKTLYEAKSENLGQGDKADYFSCVGTVVYLRKENCMYQACPSQDCNKKVIDQQNGLYRCEKCDREFPSFKYRMILSVNIADFQENQWVTCFQESAEAILGQNTAYLGELKDKNEQAFEEVFQNANFRSYTFKIRVKLETYNDESRIKASVLDVKPVDYREYGKRLIMNIRKHAARQM
The following text describes a protein:
Function:
Component of the hydrazine synthase complex that catalyzes the condensation of nitric oxide (NO) with ammonium to form hydrazine. The beta subunit may play a role in modulating transport of the hydroxylamine intermediate through a tunnel between the gamma and alpha subunit's active site. Is involved in anaerobic ammonium oxidation (anammox), a biological process in which nitrite is used as the electron acceptor in the conversion of ammonium to dinitrogen gas (N2) and water; this bacterial process has a major role in the Earth's nitrogen cycle and has been estimated to synthesize up to 50% of the dinitrogen gas emitted into our atmosphere from the oceans.
Subcellular Localization:
Anammoxosome.
Sequence:
MVIRRKMNKMIRKGMIGAVMLGAAVAISGGVATAGYIQGTHVKTDLPGPFHITMSPDGSTLFISNQSGHSVTFVDARTQKVTGEVAVRVQPEASAVTPDGAFLYVCNAESDSVSVVDIQRKQEIKEIKVGDWPSGIKISPDGKTAYVACSGCMWNAIDVIDTGRMEKVRSIYTSDYGPRMVEISPDGKTLVAILDTVGSINRSVDFIDIASGRVVENRVIHESSNLRDVVYTPDGKYIAVTHQTPKNWLPVCEAENGQVFTNNVTIIETKAGGKVARLPLDDLNNYDGNPYGMAMDPKGKYLYIGVRGMHRVTILDMDKVLGLVRSSTQEELDYLRDDLGLVRDYLVARVPTGLGPSSVCLSPDGKFCYAANYFSNNVTVIRTAVD
The following text describes a protein:
Function:
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MPSNALWLRADQLSSVSPAVLDWLFDEGSLTRRLTALADGAFRVEPLLEGWQTLRDDECQGLDVPTGSSGWVREVYLHGHDRPWVFARSVAARSALEGSGFDLALLGTRSLGELLFSDSAFERGPIEVCRYPAAGLPAEVRAEGLWGRRSRFSRGALGVLVAEVYLPRLWDQAGIADV
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Sequence:
MTRPLALIIFLVAILTNTDPSRSDAGSDPVNYLFRGPVTAVAAIAGEGEHAGIKGSLTFLQKSLDGRTVINGTISGLPEGKHGLHIVDSGDMTKGCYITTAKGHLNPFNLSHGAPSDSARHVGDLGNIYADDTGISVINLTDTVISLFPTPAFVIGRILVIHTTYDDLGRGGSPVSKVNGNAGGRLACGIISYV
The following text describes a protein:
Function:
Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSSPGTSMFTNFTKLCKGLALVLVVGHLVVQFIPATVPYLALIPARTIPFAWNLITSGYFELSVYGVVFSTVSLLFMGKFLEPVWGSTEFLKFIFVVNFLTYLCVFVTAIALYYITRLEVYLYMPFAGFHGVLAGLLVGIKQIIPDQEILLLKIKAKWLPSIMLILSIASSFFTLDSAAYLPTLIFGTYMGWLYLRYLQRRPETKLRGDPSDDFAFSTFFPELLRPVIDPIALIFHRMLCGRSNATSEDHDYSTSGAPLPGSDSAEASRRRERGARALEERLGTERLVPARNKDELQSDGLDNV
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MESPLATTLGTRMSAYLITSNDFKKQRQKINKQIKNLRHELNLINHDSKKYKVVKFTKDQYQSNKNYGLIYLLLAERDFLYGLEMKNILEIDDIKSKSKSKSNSNSKLHKNYKKLLITKFKRSLIHAKELLDLTNEESINDIKVELFVYTALIIGQLSIVKKNWEKTLHAFSIAKCGLDYLYNTHNNNNNNNNNNGEDENNDDDEEEADSFNKTLFNELIETLVDPSLNLAISQLEIHSTTDLKSIARKHCHDNEVPYLTPVLNLIDSKYTTTAENIANEDNFEISKQVNWRDHSAYIYNDEVALKISYLNNNIHWDKSNDINQFDSIITQWNEILSLHKSDTERNQDDDDLEQVQNRAILLTYINYNLLFTTLKRDLLLIGQLAKIDDNKDIIRLFNGILVIVQNLKDLPGVYNDEDLYDSLDNLEKFFIAQKNQVIAESYQFNSQFAESLKIYQFINQEISNATTTTKQGSSSFYKTDFPFNISTNEQIAIFKNDITKKILQNQISAQFEQSKVISSSPYTIENLNKYPKGLTTIINLNKIEPMMCKPVLFDVAFNYISYDSTKQTTTNTATTTPVETSSPDVDETIDNENSKKRGFFGIFGRR
The following text describes a protein:
Function:
May be involved in the synthesis of minor phospholipids and in modulation of IP3-mediated signal transduction.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRPKQQAQVTAAEDTASEPEPEPKPVDRKSRLRSFRVRTISSVLLIGGFIGIIWAGHVPLMFFILLLQFLVARELFRIAYIAEKSKRSLPLLRTQQWYFFFTAVFWLYLRFIKNNLLVEVTSDMTLARLFVWAVKHHSLISYSLYMAGFVGFVLSLKKGLYLHQFAHYAWTHMIILITTVPTSFFVSNVFSGILWYVLPAFLIVANDICAYLAGFFFGRTPLIKLSPKKTWEGFVGGFLGTLVIAFYLSAYMSKYKWMTCPRKDLTVFKGLDCTPDDVFIPATYTLADVNDLLPPAAAEYLRLAADRLPVPPALKAAAADFTFTVAPIQLHALSLAAFASIAAPFGGFFASGFKRAFHMKDFGDTIPGHGGVTDRFDCQIVMAVFAYTYYWSYISKPEVTLGDVLNSATKLNDHDQILLVGKMANLLAAEGLIPGSIVDALRKHLGNRFTWEVPDS
The following text describes a protein:
Function:
Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response.
Subcellular Localization:
Host cytoplasm. Host nucleus.
Sequence:
MDLKPFARTNPFSGLDCLWCREPLTEVDAFRCMVKDFHVVIREGCRYGACTICLENCLATERRLWQGVPVTGEEAELLHGKTLDRLCIRCCYCGGKLTKNEKHRHVLFNEPFCKTRANIIRGRCYDCCRHGSRSKYP
The following text describes a protein:
Function:
Involved in the catabolism of gentisate (2,5-dihydroxybenzoate) a key intermediates in the aerobic pathways for the metabolism of a large number of aromatic compoun such as naphthalene. Catalyzes the hydrolytic cleavage of fumarylpyruvate to form fumarate and pyruvate.
Sequence:
MGRPVDKSVEQAFYFTKSPQTLVESGATVAYPPRTSNYHYEMELVLAIGKPGFRVSEDQAHELIYGYAAGLDMTRRDLQLVARDKGRPWDTGKDIEEGSVCSEIVPMQGVVVEQGAIALEVNGQTKQSSNVDKLIWNVREIIADLSTYYHLQPGDLIYTGTPEGVGAVVAGDKIIGRVEGIAEISLTVGPAE
The following text describes a protein:
Function:
Transcription factor that binds a motif with the core sequence 5'-GCGTA-3' in the promoter of various genes. During development, required for cell fate specification probably by promoting or repressing expression of genes involved in specific cell fate. Involved in head epidermal morphogenesis. Involved in gonadal distal tip cell (DTC) migration, during which modulates expression of the integrin alpha genes, pat-2 and ina-1. Regulates ventral and dorsal cephalic sheath (CEPsh) glia differentiation and expression of transcription factor hlh-17 in CEPsh glia. Plays a role in establishing unequal cytokinesis and cell fate specification in male-specific postembryonic blast cell B. May cooperate with the phosphatase eya-1 and transcription factor ceh-32 to regulate the transcription factor ets-5; [Isoform a]: Transcription factor involved in head epidermal morphogenesis and required for normal cell fate in anterior lateral epidermal blast (seam) cells. Required for the generation or differentiation of neurons of the anterior ganglion, probably acting upstream of unc-86. Represses BAG sensory neuron fate in non-BAG cells, probably through cooperation with the phosphatase eya-1 and transcription factor ceh-32. May be involved in regulating the generation of dopaminergic neurons. May cooperate with hlh-17 to preferentially regulate expression of hlh-17 in ventral CEPsh glia; [Isoform b]: Transcription factor that acts within the male-specific genital sensilla (simple sense organs) known as rays to determine their identity. Promotes BAG sensory neuron fate in a cell-autonomous manner. Required for function of chemosensory BAG neurons.
Subcellular Localization:
Nucleus; [Isoform b]: Nucleus. Cytoplasm. Note=Nuclear localization is temporally and spatially regulated in two sets of neuronal sublineages.
Sequence:
MSDAGHTGVNQLGGVFVNGRPLPDATRQRIVDLAHKGCRPCDISRLLQVSNGCVSKILCRYYESGTIRPRAIGGSKPRVATSDVVEKIEDYKRDQPSIFAWEIRDKLLADNICNNETIPSVSSINRVLRNLAAKKEQVTMQTELYDRIRIVDNFPYNSSWYGQWPIPMNGAVGLNPFVPAPLIEPKTEGEFEKDEDQKPPTEPEDDAAARMRLKRKLQRNRTSFTQVQIESLEKEFERTHYPDVFARERLAQKIQLPEARIQVWFSNRRAKWRREEKMRNKRSSGTMDSSLSNGTPTPTPGSVTGSNMTNPIGSPASTPNRFPSNNSANLPTTNFVPQTSQMYAGLSQPAMDPYSFGIANGFSMAPYPQVTDFQPHHMFQGRSPYDFPYPRMPTNGHGFQQSMSPATTAVGDIPTLSSGMSLPVSAVLNSIDPSLTHSQMHELSDLTQEHYWRPQ
The following text describes a protein:
Function:
Capable of resolving Holliday junctions. Specific for 4-way junctions. Seems to be important for the maintenance of mitochondrial DNA. Cleaves fixed junctions at the point of strand exchange. Cleaves after 5'-CT-3' sequence.
Subcellular Localization:
Mitochondrion.
Sequence:
MSTAQKAKILQLIDSCCQNAKSTQLKSLSFVIGAVNGTTKEAKRTYIQEQCEFLEKLRQQKIREGRINILSMDAGVSNFAFSKMQLLNNDPLPKVLDWQKINLEEKFFQNLKKLSLNPAETSELVFNLTEYLFESMPIPDMFTIERQRTRTMSSRHILDPILKVNILEQILFSNLENKMKYTNKIPNTSKLRYMVCSSDPHRMTSYWCIPREETPTSSKKLKSNKHSKDSRIKLVKKILSTSILEGNSTSSTKLVEFIGVWNNRIRNALTKKKSFKLCDILEIQDNSGVRKDDDLADSFLHCLSWMEWLKNYESITELLNSKTLVKTQFGQVFEFCENKVQKLKFLQNTYNND
The following text describes a protein:
Function:
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLKYIFKNSITSFHLLSRYQISIDKIRNFCIIAHIDHGKSTLADRFLEITGTISKGKHEQYLDKLEVEKERGITVKAQSAAMLYKVDGIEQYLYNLIDTPGHVDFTYEVSRSMRACEGAILLIDATQGIQAQTLSNYILAKKQNLKIIPVINKIDMTSANTETVIQQLVEKFDMNPNEIFKVSAKKGTGVTELLNNIVTLIPPPQDHKELKCFLIDSWYARDKGVVLLMLMKGGILKKGDQILSCAFKKKYDVFEVGIQSPENVPQEKLEPGQVGQQMRPEQEIHLEIPLSKTLAEAGFEQVKPLVYCGIYPEDPDDYAELNKSIFKLALTDPAVIIQKESSAALGNGYRCGFLGVLHMDVFRERLENEYNLSVILTSPSVPYKAILRNGKEVLVENAIMAPDAAVIKHYEQPMAMATIMCPEEYSATIFQLCDARNGRIVDQEKYDKQDRYIFKFPLNEIIQDLFDKIKSATKGYGSLEYEFCGFEKANIVKLVIHLMDDPVDALSFMVPEERAHQLGKKICQRLKDNIPQHLFVVSIQAKVGGKVIAAEKIGSTGKNVTAKCYGGDYTRKKKLLDRQKEGKKRMREVGRVTVRKDTFISVFKDD
The following text describes a protein:
Function:
Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MTNQDPDDGAYPSSQSDDDGIEALAINRQSRPLLAYEDQAAGQSDAFTDRDIPASTAPLTGRRRTPLSWTEVIWVSLTLLLIAVLGYSSQLYVMLPYYEKTPSFSPQALAAVLVPFNLGLLAIYYNYWLCVTTDAGSVPAGWQPEWSALEPVASLAELEHLHLVAEEEPSLELKQAIYRPRYCKTCSAFKPPRSHHCKTCQRCVLRMDHHCPWLANCVGHFNHAHFIRFLFYVDVTCLYHLIMISCRVLDSFNSYTYWREPCARELVWLVVNYALCIPVILLVGIFSLYHFYCLAVNQTTIESWEKDRTATMIRRGRVRKVKYPYDLGLWRNVRQVLGASPLVWCLPGAGARMAGDGLKYPVANGLDSGSQYRWPPKDPSRPHPSRRTWASSSSPFTYPERSNPILDPTLSTRFPHNSSPSSSDSHSSLHLPHPPSLLDPLPHHFDPPHDPDTQPVNCPKRVSVRRGSEGYEVRPHTPWSV
The following text describes a protein:
Function:
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Subcellular Localization:
Cytoplasm.
Sequence:
MFITGAFFDILEVGPKKIRRCFELVRVRFAPSPTGHLHVGGARTALFNWMFARKEGGKFILRIEDTDTERSSREYEQQILESLRWCGLDWDEGPDIGGDFGPYRQSERLEIYREYAEKLVEDKRAYYVVYDKEDPSKELFTTYEYPHEYKEKGHPVTIKFKVLPGKTSFEDLLKGYMEFDNSTLEDFIIMKSNGFPTYNFAVVVDDHLMRISHVFRGEDHLSNTPKQLMIYEAFGWEAPVFMHIPLILGSDRTPLSKRHGATSVEHFRREGILSRALMNYLALLGWRVEGDEIFTIEEKLQSFDPKDISNKGVIFDYQKLEWVNGKHMRRIDLEDLKREFIEWAKYAGKEIPSVDERYFSETLRICREKVNTLSQLYDIMYPFMNDDYEYEKDYVEKFLKREEAERVLEEAKKAFKDLNSWNMEEIEKTLRDLSEKGLASKKVVFQLIRGAVTGKLVTPGLFETIEVLGKERTLKRLERTLQFLKKT
The following text describes a protein:
Function:
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC80 complex to microtubules. The recruitment of spdl-1 to kinetochores relieves this inhibition. Required for embryonic development.
Subcellular Localization:
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the kinetochore during nuclear envelope breakdown and remains there until the metaphase-anaphase transition. Localization of the RZZ complex to kinetochores is dependent upon knl-1.
Sequence:
MASSEGSYRDLEKKLKNGLTSISQDIVDKYGNLKVSLNVNATAKLIFDRLENLEDIAEMSTRNLSNLIDQTAKDSPEMLAEIKSQAQSCENLVEFLQSMKNVEEQLIIMRSKTTNRVEWGTAILACKDFLNDTNMLLEGIGRDGFDMSVPLKHFAAEYSVLSYNCRYQLSADYERAMNVPKLSKQKCGDRTNVSFSVFNVGSVEDQKMLNETLSAMNMIGQLPERLDAWKIVILNVFCEAIVASRDGVDVYIVDNPTPDQTRFLINQKPRGKKDKTIDVAKVLESMEVFFTKLHSVLHSHELLDATGKTFTSMIGSVIEEQLITMILKDVIAIAAPVTETADEDQEMFINLLQIGEVFVERMKELGFFSQKAKLLFTLDTDTIFVTRRCFAIVSKANKLINETYDKLVTVGVDDSAIKDIDLLAKAHTHAEHFAKEYGKDLGRLWSHNEDSQFPSFFAFQKCTVSESTINFVNLLRDNVKAAFACEDEGARAKLALTAENIVRLYVILTPRKHAELFSSIPNMAAIFYNNCHYISHCIMTMSFEASGDNQKTLLEPLLLDSVIRLRTVAADCMEKTLTRCRREMTAYLEDHSIFEHLPASYKTTKNTFAAAEEMSESADILVPREEPKIIKCLAACLLHIRLIAKNLREPLTEVVYCKVIGSLVSFLLDSLVRHVVTTSDFRENDANVMADVFKRLLEVVANIVAYKEQTKVTDFCAREYFRLNEIVFVLGNRMQDIEHRWFNAKGPMAEHLSRSEVVGLIKALFADSQHRSDLIARL
The following text describes a protein:
Function:
mRNA-binding protein which interacts with a range of target mRNAs including SERPINE1, ACTA2, CCN2 and COL4A1 and may promote extracellular matrix production. Binds to the 3'-UTR of SERPINE1 mRNA and stabilizes the mRNA, possibly by competing for binding with SERBP1 and preventing SERBP1-mediated mRNA degradation. Also binds to the 3'-UTR of ACTA2. Testis-derived lumicrine factor that triggers epididymal differentiation and sperm maturation.
Subcellular Localization:
Secreted. Cytoplasm, perinuclear region. Note=Detected in the perinuclear region of fibroblasts.
Sequence:
MAPLPPCGPPRSPPPRLLLLLLLLSATLLGAPARAEPAAGSAVPAQSRPCVDCHAFEFMQRALQDLRKTAYSLDARTESLLLQAERRALCACWPAGH
The following text describes a protein:
Function:
Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
Sequence:
MEQATQQIAISDAAQAHFRKLLDTQEEGTHIRIFVVNPGTPNAECGVSYCPPNAVEESDIEMKYNTFSAFIDEVSLPFLEEAEIDYVTEELGAQLTLKAPNAKMRKVADDAPLIERVEYVIQTQINPQLANHGGRITLIEITEDGYAVLQFGGGCNGCSMVDVTLKDGVEKQLVSLFPNELKGAKDITEHQRGEHSYY
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MKKAGITIIHRNAKRSLNTTQDIIQAHHKTAAAHVTGAPHQPTVPKTSASLPPTTTTMDSFFADGGSDELQRTASHPFDDDSTSAAAASGGEAEGYSSFAAAGFSSFIDPEAAEFQGEDVDEEIDAESDGGGVPVPVRHVSGGYSPSPFLPDDSDDFGGPVLPPPAEMGREEGAALREWRRRNALELEEKERKEKELRAQIIAEAEEFKIAFYEKRIQTCETNKVHSREREKIFVENQEKFHASADKQYWKSISELIPHEIATIEKRGKKDKDKKPSIAVIQGPKPGKPTDLSRMRQVLVKLKHAPPPHMLQPPPAPVAAAAGAKDAAKDGMPAPANGTKQPAESKETPTNGPVEVEKEQPAASE
The following text describes a protein:
Function:
Highly active against Gram-positive bacteria M.flavus strain ATCC 400, M.luteus strain CECT241, C.soprogenes strain NCTC533, L.monocytogenes strain ATCC 19111, L.inocua strain ATCC BAA-680D and S.carnosus strain LMG13564. Less active against B.cereus strain LMG13569, C.thiaminolyticum strain ATCC 15579, E.faecalis strain NCTC8176, L.lactis strain LM0230, L.casei strain ATCC 344, L.lactis strain IL1403, L.jensenii strain ATCC 25258, L.plantarum strain CECT220, L.brevis strain ATCC 8287, L.bulgaricus strain LMG13551, P.acidilactici strain ATCC 25740, P.pentosaceus strain ATCC 33316 and P.pentosaceus strain LMG13560. Weakly active against L.mesenteroides strain ATCC 19254, L.lactis strain ATCC 1454, L.sakei strain CECT906T, L.lactis subsp. cremoris strain MC1363 and L.curvatus strain ATCC 51436. Not active against Gram-negative bacterium S.enteritidis strain ATCC 13076. The mode of action appears to be non-lytic. Inactivated by proteinase K, but insensitive to trypsin, alpha-chymotrypsin, pepsin and papain.
Subcellular Localization:
Secreted. Note=Partly adsorbed to cell wall.
Sequence:
KNYGNGVYCNKHKCSVDWATFSANIANNSVAMAGLTGGNAGNK
The following text describes a protein:
Function:
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Plays an important role in the de novo pathway of purine nucleotide biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
SMAADGVVTNGREQASLNGEPDAKRARVPAEPRNQVTVVLGAQWGDEGKGKVVDLLAMDADIVCRCQGGNNAGHTVVVDGVEYDFHLLPSGVLNRNAISFIGGSRHELSLKHSASLSSSLSLKDTASLSSSLSLKDTASLSSSLSLKDTASLSLPLLFPSLPVYLMHMCAIWLPQLWGPVLESSCVTVVMMCSWLCGPVLTRLPVVVPLQEIGALLQARGREFGVTTGRPRRCGWLDLVLVQYAHMINGFTALALTKLDILDTLKEIKVGVAYTVNGQTIPSFPANLDTLSQVSVQYETLPGWECSTEGVRSFGDLPPKAQAYVRFVENYLQVPVKWIGVGKSRESMIKLF
The following text describes a protein:
Function:
Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Subcellular Localization:
Cytoplasm.
Sequence:
MDPFLVLLHSVSSSLSSSELTELKFLCLGRLAKRKLERVQSGLDLFSLLLEQNDLEPGRTELLRELLASLRRHDLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDNIEDRYPRNLTERVRESLRIWKNTEKENATVAHLVGALRACQMNLVADLVQEVQQARALQDRSGAMSPMSWNSDASTSEAS
The following text describes a protein:
Function:
Covalent carrier of the coenzyme of citrate lyase.
Subcellular Localization:
Cytoplasm.
Sequence:
MKINQPAVAGTLESGDVMIRIAPLDTQDIDLQINSSVEKQFGDAIRTTILDVLARYNVRGVQLNVDDKGALDCILRARLEALLARASGIPALPWEDCQ
The following text describes a protein:
Function:
Mitochondrial protein involved in the maturation of mitochondrial [4Fe-4S]-proteins in the late stage of the iron-sulfur cluster assembly pathway (By similarity). Required for normal heme biosynthesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MQRMILFGGALREIVVRSGGLQAHYFLCTSRTRIKTHSQTRAASSTAHFSCYRLPHRTVLNVSGQDTSSFLQGIITNDMNLLGEDSLNAMYAHVLNVQGRTLYDIILYSLKGNPDGLNGVLLECDSTVQDSVMQLLKVYKIRRKVNLSVCPSLSLWALLPHSKEAVLGRPDVTTTDKVLVLEKDPRTELMGWRMITSAQDNPLDIVSACRLGNTEEYHRHRYEIGLPEGVGDLPPGEALPLEANLVYMQGISFSKGCYIGQELTARTHHTGVIRKRLMPVSLSAPAEKLNQGSALQTEGGKPAGKYRTGVDKLGLSLVRLAHAKETLQLKSSGDETVTVLASVPDWWPKTPQEK
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSFALRLGSSIGCFHRTILGRDIIQRKSHVVSYRNGPPPHSKATKIGALTVGGAMWWWVIWHLWHEPDHITGEFDYPNSRKWSNTELGVPKDGF
The following text describes a protein:
Function:
Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress.
Sequence:
MPPSGRFDRTIALAGTGHLKIGNFVIKETIGKGAFGAVKRGTHIQTGYDVAIKILNRGRMKGLGTVNKTRNEIDNLQKLTHPHITRLFRVISTPSDIFLVMELVSGGELFSYITRKGALPIRESRRYFQQIISGVSYCHNHMIVHRDLKPENLLLDANKNIKIADFGLSNYMTDGDLLSTACGSPNYAAPELISNKLYVGPEVDLWSCGVILYAMLCGTLPFDDQNVPTLFAKIKSGRYTVPYSMEKQAADLISTMLQVDPVKRADVKRIVNHSWFRIDLPYYLFPECENESSIVDIDVVQSVAEKFDVKEEDVTGALLAEDHHHFLCIAYRLEVNHKRNADESSQKAMEDFWEIGKTMKMGSTSLPVGATTKTNVGRKILEGLKKEQKKLTWNLGIRACLDPVETMKHVFLSLKSVDMEWKVLSMYHIIVRSKPTPINPDPVKVSLQLFALDKKENNKGYLLDFKGLTEDEEAVPPSRCRSRAASVSVTLAKSKSDLNGNSSKVPMSPLSPMSPISPSVNIPKVRVDDADASLKSSLNSSIYMADIENSMESLDEVSTQSSEPEAPIRSQTMEFFATCHIIMQALLAE
The following text describes a protein:
Function:
May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion.
Subcellular Localization:
Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane. Cytoplasm. Nucleus.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for localization to the endosomes.
Sequence:
MASPQHPGGPGWTGPRNQCITRTRQEVLPPGPDLPCPGPEEAQDGPTSNSNMTTRELQEHWQKEKSRWKHVRLLFEIASARIEERKVSKFVMYQVVVIQTGSFDSDKAVVERRYSDFERLQRALLKRFGPELEDVTFPRKRLTGNLSAETICERRLELREYLRLLYAVRAVRRSREFADFLTRPELCEAFGCLRAGQYARALDLLGRVVPLQEKLTAHCPSAPVPALCAMLVCLRDLERPAEAFAVGERALRRLGARESHRYYAPLLDAMVRLAYALGKDLASLQGRLDESQLRRPTHRGATLKELTVREYLS
The following text describes a protein:
Function:
Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEGTSQRPLTPLSQAFLSTNTLSPASSPLTFHSEAASLRRKRSNFFPKLDELNGAQDEEMRGLNIPGGSGYLENRYGRDKFTFSDAAVNSAGMGGSGIFSHNNADDGLGDGSSTVLPSSLKQMLDPEISTANNPSAKPRRTRLQTAWKEATNSAGLSLRSASALDVLKNSGPATTSLLSSTTYPFDSLNAFNEPSHSHVPNSASSTALSRGMSNSVTLTAPPEPDEETIPTAIVIKNIPFSLKKEVLFKVFTALDIPRPYAFNYHFDNGVFRGLAFANFHSPEEAKTVVQVLNGYEITGRRLRVEWKRQLPPAERERVERGKQEKRAVEERKNQLKSPFSVANIGAGIDFDLNDPAILNVYSHILLFYYRSDNTNDLVFDSSTTQEERRVAALLASRLNLNHSVTGDGEAKQVVITMPSTHFTPANNSSANHSPLMAPNASTLNPSSLGASNLSQPSLANHLSSSGLFDNGLFSSGGLSSNFSSLRRPAPSMHLADSIRSLRGLNDSKAFSDIRSMPATPLELATPFANLNVSSPLDRNATNSSNTLNGSAMNDYFASLTPSNTGAIGSRTFTKN