lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the biosynthesis of porphyrin-containing compound.
Miscellaneous:
MISCELLANEOUS: HemZ is able to complement a S.typhimurium hemF hemN double mutant under aerobic and anaerobic conditions, however under anaerobic growth conditions, the double mutant complemented with hemZ grows significantly faster.
Sequence:
MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISLALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTGITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAAVPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEWLKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITEEKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLIIGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMMEDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCGAASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH
The following text describes a protein:
Function:
May modulate lipid droplet formation throught interaction with SQLE.
Subcellular Localization:
Membrane; Single-pass membrane protein. Late endosome. Note=Partially colocalizedes with LAMP1 in late endosome.
Sequence:
MAVSTEELEATVQEVLGRLKSHQFFQSTWDTVAFIVFLTFMGTVLLLLLLVVAHCCCCSSPGPRRESPRKERPKGVDNLALEP
The following text describes a protein:
Function:
May have microtubule-stabilizing activity.
Subcellular Localization:
Golgi apparatus. Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules.
Sequence:
MAWPCISRLCCLARRWNQLDRSDVAVPLTLHGYSDLDSEEPGTGGAASRRGQPPAGARDSGRDVPLTQYQRDFGLWTTPAGPKDPPPGRGPGAGGRRGKSSAQSSAPPAPGARGVYVLPIGDADAAAAVTTSYRQEFQAWTGVKPSRSTKTKPARVITTHTSGWDSSPGAGFQVPEVRKKFTPNPSAIFQASAPRILNV
The following text describes a protein:
Function:
With LigD forms a non-homologous end joining (NHEJ) repair enzyme. Binds linear dsDNA with 5'- and 3'-overhangs but not closed circular dsDNA nor ssDNA. One dimer binds for every 30 bp. Recruits and stimulates the ligase activity of LigD but not of T4 ligase or a human ligase complex (LIG4/XRCC4). Attenuates the 3'- to 5'-exonuclease activity of LigD. Stimulates the template-directed addition of dNTPs by LigD on 5'-overhangs and nuclease activity on 3'-overhangs.
Sequence:
MRAIWTGSIAFGLVNVPVKVYSATADHDIRFHQVHAKDNGRIRYKRVCEACGEVVDYRDLARAYESGDGQMVAITDDDIASLPEERSREIEVLEFVPAADVDPMMFDRSYFLEPDSKSSKSYVLLAKTLAETDRMAIVHFTLRNKTRLAALRVKDFGKREVMMVHTLLWPDEIRDPDFPVLDQKVEIKPAELKMAGQVVDSMADDFNPDRYHDTYQEQLQELIDTKLEGGQAFTAEDQPRLLDEPEDVSDLLAKLEASVKARSKANSNVPTPP
The following text describes a protein:
Function:
Component of TORC1 complex, which is an essential cell growth regulator that controls plant development. Acts by activating transcription, protein synthesis and ribosome biogenesis, and inhibiting mRNA degradation and autophagy.
Subcellular Localization:
Endosome.
Sequence:
MILFLIGLFLGVQTELISGDHNGNIRVWDLTANSCSCELVDTSMRSLTVMWDGSLVVAVNNKGTCYVWRLLRGTQGTNDGYGIGHLARNMFPGSSNFNSSNGLADVVLGSASETPISNILEPAFFSSLPTIHSMIIFVCINRGQSPTEGGTRGEEVGQGQGPLKDSPVLMYLPGLEGTGTGLVDMRKLLESGLNLDKSLLSEMGQCTTAYPYNQLFGALVLKNYERQDETLLSWNLMYIVD
The following text describes a protein:
Function:
Involved in protein precursor import into chloroplasts.
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein. Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MQGVITKPCFYAPVVLNHHYRNPVRHHVEVPSTFSLPLKNTFPSFKTKACPLRVGAFLTSSTPLVMNKQVMDDDLQFAPLKRGSSYLPRASKDKLFSFPPYPKMTEKPKWWWRSLACLPYLMNFLDQLTWAYAHPTNNPPPFLENFDNLAFPLHSSLLALPKFFLSCYPIMFYFWIVRRKEWPHFLRFHVISAVLFGSLVQVIGISSNWFPSRFFPPHFWSAATFFFLVTVFDCMRCAIAGEYSGIPFVKDAALLHSDLNLR
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.
Sequence:
MTSSGRLRRRPPARDAHAAPGRPENDEVQDCIKPVKVDRRPGSGVAKIHIEDDGSYFQVSPDGGTQRLEKAKISLDDCLACSGCVTSAETVLITQQSHEELRKVLDANKTAAPGQQRLVVVSVSPQSRASLAARFQLSPTDTARKLTAFFKKIGVHYVFDTAFSRNFSLLESQREFVQRFREQTNSTQALPVLTSACPGWICYAEKTHGNFLIPYLSTARSPQQVMGSLVKDFFAQQQHLTPDRIYHVTVMPCYDKKLEASRPDFFNQEHQTRDVDCVVTTGEVFKLLEEEGVSLSELEPAPLDSLCSSMSAQEPSSHRGGGSGGYLEHVFQHAARELFGIHVDEVTYRPLRNKDFQEVTLEKEGRVLLHFAAAYGFRNIQNLVQKLKRGRCPYHYVEVMACPAGCLNGGGQLKAPDMPSKELLQQVEMLYGMVRTEVPENVPGVQELLVKLLAQGEEPSCTGQQWTLAGEEHPAHSTCAGDGVPVPPGTGCWTPWLLGPENLCFWASSRWEAGSVDQAGSPIPQLGPPDWVGERTDCAEPARPVTTELQI
The following text describes a protein:
Function:
Not essential for mitotic growth but is necessary for normal morphogenesis. Involved in the organization and/or function of the actin cytoskeleton.
Miscellaneous:
MISCELLANEOUS: Present with 2610 molecules/cell in log phase SD medium.
Sequence:
MKMAVDDPTYGTPKIKRTASSSSSIETTVTKLLMSTKHLLQVLTQWSKGTTSGRLVSDAYVQLGNDFKVVSKFFMHAKVDMSDVGDVPMALRRVLEVTLREPPSDETLNKHLPKIREIIVTLLDKLKVKQAILKNMQQEHRISVKSHHQQNPSFTSNLSLGSEGTREGTPLSSRKSSIVRDQRQSDSVENSYGEKVNSTSTGTPSAQSAEATLTKPRTNIKQNLKSNNAPNASDDDDALSQLKKGTNLQRRASKRYSAYHMAKLTNQSTTEAAAAAGLMTTPSPSMLHLEETVRKSKLYGNNNNDDDRNINSAENKGKSIDDVSKASPLAKTPLPIENVRASPRRLSSVVTTSPDKAMNGTCPVFLRIGDKTKKCHVQLPTTKNALRLLFIERFAYSPGANSFPDIYIMDPQYGVFYELEELNLLDIKEGFVIELKLEENPNNTIKEFIDTVKMEISNSQNDIIRHLKEMSFGSAISGKQTEVLPQPGLEANKHDLVGQNKKDDDKTIKDIQYELGKIKQVHNINRSNINETIFNILRKVDNFKSLSFSAKNSSNRMYMEKSQTELGDLSDTLLSKVDDLQDVIEIMRKDVAERRSQPAKKKLETVSKDLENAQADVLKLQEFIDTEKPHWKKTWEAELDKVCEEQQFLTLQEELILDLKEDLGKALETFDLIKLCCEEQEKNPSRSKSNPILPIMRPGTFNQVREQVMVAVQSLNPDHDSRVEAIDKAEKMWEMERKLKASNEFDDELENFVGNSNLKKSGGFEEVERIRKQKDEANLRAYFGPGFT
The following text describes a protein:
Function:
RNA-binding protein required for the maturation of the box H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex and ribosome biogenesis. During assembly of the H/ACA snoRNP complex it associates with the complex and dissociates during complex maturation, becoming replaced by Gar1 to yield mature H/ACA snoRNP complex (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MESEQPAAVKASAPIEEPQSTETAVELGKHSTLKADLSIDKLETATTEATNAVVEPVEMEQQVENELVNESTQAMTSTTTQEKVVGSVNNLVEEQQCVEMEFETSSDLVVQGSPSEESKKVASDASATVTAPQVQPAPHVDSSPQASGLSLLAAYSSDDSDDEKVTPVQNGDNDVIEVPVTDPASSTTAYRPVVAVSSDDESSKSSSSSSDSDSDSEGEYLTVLRKKIDKRINTVDCDEDDEDFDEDGATGDRSRRRQPPKVRGEMLLDDLPPIHQLEITVPEDECVELGKVQSIVDQLVLVSVLPNSMLFDLDTVLFLEKGRKVLGEVFDVLGQVSDPLYCVRFNSNKQILDRGIKIGDVVYCAPKTEHTQFVILSKLMQVRGSDASWEHDVEPPARYVDHSDDEEEREARAEQRKRRQRDRTNSTDSVDTVTSVATTATKASSVAPPPRQRGRRGQRESFRQSQRPSINQHNQNQPQDEQYNFHPSYNPGSWHSNYYQNYHQAAANFNMAQQHPGMPFPVPNYGYGMPYAMPPMYPHMYPPPPPFAPPPPNNQSHQGQPPPS
The following text describes a protein:
Function:
May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic stem (ES) cells into a primitive ectoderm lineage (By similarity).
Subcellular Localization:
Nucleus. Note=Associated with transcriptionally active chromatin.
Sequence:
MEPSGSKKGRAEEPREEVECQMSSQPSTSSAKTKATGKKQRKSEKDDGCKPEEKSAQDPETPGHARRKVPVPPFPQHLPPVNLIHRDVLRAWCQEMKLSSKGQKLDAYKRLLARAFPDQMPELKNVPDSAKEARLKMPRKKMKTEPGEESQVTVPLEIVTVPEEQIPALVDPPVLYEEVSTTVVTTSASEAVLASWARIAANAKKLEAVPSNATSETYGSTGEMWCVVHGTSLPATSSGWVRLQFHAGQAWVPDKKGKAIALFLLPACTFPPPHLEDNMLCPKCVHKNKILTKSLEG
The following text describes a protein:
Function:
E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (By similarity). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3). Plays a role in the lineage differentiation of the germ layers in embryonic development.
Subcellular Localization:
Nucleus. Nucleus speckle.
Domain:
The polyhistidine repeat may act as a targeting signal to nuclear speckles.
Sequence:
MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSADNRAKLELGTQGKGQGHQYELNSKKHHQYQPHSKERSGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEAPSPTCPDLGTKSHPPDKWAHGAAAKGYLGAVKPLGGGAGAPGKGSEKGPPNGMTPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKIKSGEAAEGEARSPSHKKRAAEERHPQGDRTFKKAAGASEEKKAEVPCKRREEEALVSGDAQPQDLGSRKLSPTKEAFGEQPLQLTTKPDLLAWDPARSSHPPAHHHHHHHHHHHHHTVGLNLSHARKRCLSETHGEREPCKKRLTARSISTPTCLGGSPVSEHPANVSPTAASLPQPEVILLDSDLDEPIDLRCVKMRSDAGEPPSTLQVKPEAPAVAAVVAPAPASEKPPAEAQEEPVEPLSEFKPFFGNIIITDVTANCLTVTFKEYVTV
The following text describes a protein:
Function:
May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.
Subcellular Localization:
Cytoplasm. Early endosome membrane; Peripheral membrane protein.
Sequence:
MGRKKTCIVTAQAQRKPSQALVADVSPWAWEEAHAQKEGSKAKATLLGRGEAEGGKAGRRRRGPGPGGVRGRGCGPGAHEVKAQEKKTHSCSNFRMDSYFKAAVSDLDKLLDEFEQNTDELENSKNANPHDSTKHHSLSSELDYQKPKVLEPKVQDNVSCPTSVESPLSTQTANVANFEQLNSEQNEKNVTGLDLLSMVDGGSSDKNQSSCLGRYSIPVCDLISDTASIPATATNMSAHCSSDTDVQQQIDGDTALYNVEYNTSEKQDELVVTTNKPSQPRVADSGEIQEKTEPLNNNEVLKQIEQVIDPALITQVSSTVHSSKDKATCEKLPCEPLEDKNSAMNQMTQKENDMVVSSEEDMVESLISILPKMYQSNENSSTLPKEDNLHDSLLQTENVPGLNQTHSTPENFCSLEQNASIGLNIVSSPESSEDIQTSLSCLPLAVSICGSLVKTDDTEGRTAEDEVTPHIVNNITVQTESHKNGLSKGELSERTEPSEQDENQNKMSQFCPGIHSFTEKEKEGFHNNINECQPFQHQNPVASSSSSFANTGACSNVLPTDIGIRGLVDLALEEDIIGGDMLVSDAELDAFLSEHCRETEHSKPLKEDTDDGLLQSDVINGNLIDLDKLNRGSNNLESEMEFKKIEPSIGNSYILSNPEGRLDNLSEESPQWKNLKSGKKDTVEKSEETTYHVNETRSEVSDLINSEQIAHSGGARPKQLLNVSPKANTCSEFSSPNTLGNESQVLNSTVPNASFSDGKICLDSSSSYNNADTQSKENNGSSILPVISESATVVERATVLGQKQPPWIPDSEAPNCMNCQAKFTFTRRRHHCRACGKVFCTSCCNRKCKLQYLDKEARVCISCHESINKAQALERMMSPTSPVANSAISEYSSEPPLQAAQTSGVCPKEQRRVWFADGILPNGEVADTTKLSSGVRKSPQEPYPVESPTKDTLCASEKIPKDETCIAGRTEILCCPTSVLPEEDTLSTKKQPELSHDSDSVVTAVTELPTVVESAMHPVPGTVNEANDTPVSPLDYRMLCGIENSVSKEISLIPEGNGLPPLLLTRGEKGKSSLVEEYPSQEQVTSLLEVSNPVTFILNANFLVNVKILSYCSERCWYFSTNGLHGLGQAEIIMLLVCLPNEDDVPKEIFKLFIKIYKDAMKGKFIGNLENITFTEDFLGNKEHGGILFVTPTFQKMDDLVLPKNPFLCGILILKQEVPWAKVFPIRLMLRLGAEYGDYPTPLTSIRHRKPLFGEIGHTLMNLLVDLRNYQYTLLTIDNLVIHMEMGRSCIKIPLQRHNEVIKVMNTSNEHVISIGASFSSEADSHLVCVQNDEGVYQTQANSATGQPRKITGASFVVFNGSLKTSAGFLAKSSIVEDGIMVQITPETMNGLRQALREKKDFRITCGKVDSGDLREYVDICWVEDERKINMSVTSPIDGKSMEGVQSEKIVQEECFEMDGKLVKCTEVFYLLKASESYNHAHQFAKEIALASCTALRQHLKTLKSNGMNKISLRVSMDTDMVEYQAGSGGHLLPQHYLNDLDSALIPVIHGGTSNTTNLPLEIELIFFITESLLM
The following text describes a protein:
Function:
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3.
Subcellular Localization:
Nucleus.
Sequence:
MKRAHPDYSSSDSELDETVEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHLPWGSAFGHHPHVAHPLLLPQSGHGNTGTSASPTDPHHQGRLAAAHPEAPALRAPPSGGLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTEIGAF
The following text describes a protein:
Function:
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MKSIELIDIESIASDRAGITREDGVIELLSEADEALGRRPYPSSPTIRSTEANIDESIGNRQLWLQSIELNGEFQEDDSEEVEETIGKKPDDALVCSDACSAPDVSIQELLQTFTPPKPHAGRVMKAGAGPVRGSSRQTSSKLQTKDVLQDILVELDDNLSSWDTPSTSGIRSPETVATLAAKWANKTEKTSGKPLYGRPRSSGNRGNILLKRTLANRNNILSSELGGESSPSLQALTTPLPAKSNDGDKNQTTNVMTTGGFRLGTMEKQTLNGSACVDRIQQVPVSSPESVSFLEGLSDIPISKPVQLTQRCIAATNTGYTKDNCASTPRSAAAVEYLEPIDTDTSILSTAGEALPHSPVKPSKVSRERSKRDYIVHSKAFTAEESKAKIRQLMSNTALKKQFNEVNKVTREKQSLLAEIVLSINEQVHQYLLEQKVPIAEVLGPTTVIHNFESVPIIRFKRKCTSMYDLNNDIYYPCETTMCNEPICLLFYNAVDFFTKYKNQKQRLYSEVQDLKRAGNKVIIILNEYSRLEKSLAELENRCMRSRVEQQLTGDKSPRRKTVKEVQLTALEMNSKDLGRKVNEMIIKCDIDIFPINSAASFANWISNLVWVVAKMRYDPMMKNVNWSHINVKIGKTPTEVLSKTLQQINGVTEIRAGRVTSTYPSFQQIFTDFEKGYLVAGKDGNPLMTKVAEKAMNALLMSEDPEEQIYIN
The following text describes a protein:
Function:
Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MAPAAAPEPSYRKDEKVFCFHHELLYEAKVLEVKPLEGEDKKSGFQYRVHYKGWKNTWDDWVPEDRLRKLSPENRELANNLRHEVIAAQRAARAQPPPPKKKAQGSARGSEERQTSVSAAAPRGQKRMRDNDLEKEDTFQNKRAVRIIMPDRLKSLLVDDWENVTKNLQLVQLPSSQPAGVILDKYQEYALSTGHKNSTERDILEEVVAGLKEYFNKSLGRLLLYRFEREQFYDIYTRLEKPTDDLAGKNLADIYGGEHLLRLFVTMPELIAQTNMDHQAVSRLREELGQMTAWLAKDAQVNAFFASVYESPGQAYIDKVKSST
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLQALSALAAIECVVLLLLVSRFSPLSRAAGSCVGIFVIGKGRALSRLIIGYLSIAFATAVFRMRTASLVDLHYQRALAALTGSSLFVAIVIRQIHRIVCQDEPLRETLRLLKLQLEISENEKFQLKQKQVEFDHLEHLVSDLRARMERMNLDSAAKDGTINDLRAKLENMKIDAEGRTKELRAAEASVQALKKQGEGFLLEYDRLLEDNGHLRNQLAYFDRKYSGSDTKKKS
The following text describes a protein:
Function:
Golgi membrane protein involved in vesicular trafficking.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MMEATPTPGSLSWRLSSHPITLLTFLAFRSSSLLVYLFGLLFTDNLVMIFIITILLLAGDFYYLKNIAGRRLVGLRWWNEVDPNSGDSHWVFESSEPGTKIINATDSRFFWLAIYAQPLLWVVLAIVALFSLKFIWLPLVAIALVLTITNSLAFSRCDKFSQASNIAGTAFSSGNIAGNIASNMVGRFFSR
The following text describes a protein:
Function:
Catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores, such as pyoverdin. Pyoverdin is a hydroxamate siderophore composed of a 6,7-dihydroxyquinoline-containing fluorescent chromophore joined to the N-terminus of a partly cyclic octapeptide (D-Ser-L-Arg-D-Ser-L-N(5)-OH-Orn-L-Lys-L-N(5)-OH-Orn-L-Thr-L-Thr in strain PAO1). Specific for NADPH, which plays a role in stabilization of the C4a-hydroperoxyflavin intermediate.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTQATATAVVHDLIGVGFGPSNIALAIALQERAQAQGALEVLFLDKQGDYRWHGNTLVSQSELQISFLKDLVSLRNPTSPYSFVNYLHKHDRLVDFINLGTFYPCRMEFNDYLRWVASHFQEQSRYGEEVLRIEPMLSAGQVEALRVISRNADGEELVRTTRALVVSPGGTPRIPQVFRALKGDGRVFHHSQYLEHMAKQPCSSGKPMKIAIIGGGQSAAEAFIDLNDSYPSVQADMILRASALKPADDSPFVNEVFAPKFTDLIYSREHAERERLLREYHNTNYSVVDTDLIERIYGVFYRQKVSGIPRHAFRCMTTVERATATAQGIELALRDAGSGELSVETYDAVILATGYERQLHRQLLEPLAEYLGDHEIGRDYRLQTDERCKVAIYAQGFSQASHGLSDTLLSVLPVRAEEISGSLYQHLKPGTAARALHEHALAS
The following text describes a protein:
Function:
Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MIPPVQVSPLIKFTRYSALLVGMIYGKKRYDYLKPIAEEERRIEAEEKKKREELERIAKELAEGGLLGRIAHPPWGTIHPKAADVQSQRSWTTASVHSSLGSAITSVAVEVNFTCGVSHVRTAEGSLLGSRLLLFSFPPHNTAAAACFLLSLGLLL
The following text describes a protein:
Function:
Not known. Putative receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDFTENEEEYEHWTHIERRVPFQGYRTYVASTYISFNVVGFVINAWVLYVVAPLLFAPAIKVPKSILFYIFALCVGDLMTMIAMLLLVIELVFGTWQFSSMVCTSYLIFDSMNKFMAPMIVFLISRTCYSTVCLDKTRGEKAATLKYAIIQFCIAFAFVMILLWPVFAYSQVFTFYMNPNSTAQEVTVMRKCGFFPPPQIEFWFNLIACITSYAVPLFGIIYWYVSVPFFLKRRALTTLVASSSMDAALRKVITTVLLLTVIYVLCWTPYWVSMFANRIWIMEKKSIIIISYFIHLLPYISCVAYPLIFTLLNRGIRSAHAKIVADQRRRFRSLTDEASSQIRTAIRTIPGTKMKKNEFLTRTEEISSDKIASEAVSEFREGLPSQTSFPDETLL
The following text describes a protein:
Function:
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MVLRKVVAILLAILPIFLFAVEPIKVVRSEKEIVVLTRFEEYHFDLEKGILKDFYTLVDGRKHVFTYGNDGFDVLDEGTPLTVIEEPIVTGVGKVSEGFSDEVSIVYNYGYVKKIFTIKNNENYTFFVDIESSKPVDVTVPRVSVDTSTDRYLENYFASFNPKTRTLVLLKHDEGLLFEGTLKVNGQKRFIVFMGPNKRTLIKKAFPEDYDVLIKALVNIPGFNKWYDSVFYGLVWFFWWLKDLTKNFGWAIMLFTLIVRLILYPLYHAQTKSLINMRKLQPQIEAIKKKYKDPTKQQEALLKLYREAGVNPASGCLMLLIQLPIFMLLWSVIRYYVEEFAYSGSFLIWKDLSAGGFSNNWLFLVITIVASYYTTLLTSQDARTAWQGIIMSVIFPFLFVGLPSGLFLYYATNTLIQLAVTYYTYKRYKIKGLTTRELLGLPKKA
The following text describes a protein:
Function:
Myosin is a protein that binds to actin and has ATPase activity that is activated by actin.
Sequence:
MMIDNNCGKEKVWVPNPEKGWINGDLIKEIPGEGWLVRDENGKEIKIEKDELRMQNPVIQEGIDDMTSLSHLHEAAVIHNLIKRYEINSIYTYTGSILIAINPYTKLPIYSKEMIESFCDQPVSKLAPHVYSIAESAYREMLNFQKNQSILVSGESGAGKTETTKFLLQYFAAMGEKGNGVNTSLISEEDIVEGNNIETQVIKSTPILEAFGNSKTLRNDNSSRFGKFIEIHFDKIKGTIVGAKLETYLLEKSRIVKPPENERGYHIFYQLIKGFNNSCCLKNSSNNNKDEDSSSSSNNNIDDLKSLLKCKASDFNYLISSGCDSIDGVDDSQVFIKTENALKVMGLSNDELIGIYKILLSILHIGNIEFEKGKEEDSSIIKYGNSSFGESFSDDDAGGYNPLEISCKLLGCSVDSLKSTFCSRKMKAGNESYTINHTVEQASQARDSLSMFLYSRLFDWLVVRINQSIDKIGTEKKDNSFLFIGILDIYGFESFESNSYEQFTINYANEKLQNQFNHQIFKLEQLEYEKEKIDWSYIEFSDNQECIDLIEKKPLGILSILDEESQFPKSTPSTLCTKLYNNHSKSKNFEKPRFSQTHFIIDHYAGKVEYDTNLFLEKNKDFIISEQVSALESSNWKFLTNLFQILSKKMNGGGGTSGGGGAGGNKASSSAAGKSTFKFTSVSSQFKESLNSLMTTINSTNPHYIRCIKPNTEKRANLFDNVMVLHQLRCSGVIEQLRISRSGYPSRLVYDNFIKRYKLIVAKDFKNDDDSNESKEWNSILKETDLNSSNGGTNNQIELKRKGAELMINKLSIDISSVQFGLTKLFFKSGIIANLELLRSQTMINSATFIQKIWRGYTDRKAYTSTKHSSIYFQSLIRSYLQQLEYNSMVEENSAIHLQSLIRTNELEKQFNQLLSTTIHFQSLLRRLEDSKEFNTLMDRIKKIVKIQSLWRSNLAKKQLKLLKAEAKSLTNVVAEKNKLASKLGDIQSKLDMESQLAQKIKNENEQLSSQFSNIQIEKEKLQKDFGNINLEKEELLLKYSALESEYHQYKQQNELIISKLKQHINDLEEKQHQHSYKNNEVVGNTSFEGSTTTNNGVTSPPKSSPASPIRNSINSNSDTTISGSSDDSIDNTDSLILSPKQHKGEDRKRNHEISSISPPRSRETIGHDDDDNNVDVIPRRQFNELEKEYKELKQMDETHKQYIESLKLQITQLEEKVKKSSSHPRSLLPGIPSNINDSPKVVYTKSSITNDNSSSHHQQQQQQHNISPSNSITSTTSPINMMDSNIKSLSYKDFTNSQEIDAQQQLHQYHLNNGTNPATSTTNGSGNPLSQSSPTGSDKHIQQSTISDLVSALNFNNCQLESGKYLVDLIIKNHDSIVSKYVPSEMGGIPEPAFILSRCFLKNIYDVDATVIGTPNSTNSGGGSGTGVLDPIETNVNILIYFCDKVEEVIYRDPKSNCSALCYWFSNFYTLFNIMETYNQDTKDQLSLNDQDKALIEKLKITLQTMIVKAHKNVVKNITDYIQPILHKSLNDTTSEIDFMDPITNYLNQIQISLSLENCYINNNLCKLLFEQLFSFINAMIFNEILLRKDLCCLRSSIPIKMNISELEHWVKLHHGKEWSSSVCDKLRLLKEVVYILMIDKTQLQNDELRDEICPTLSIAQLKQLLTMYSPDVDSFEDPIPLEILTSLMDSPKYNPDENILLDLSKIFTLKFINSNQTLSSSTSSENDLMATINLNALESVQYACDDLVSNIVKKNIEIVSLNNQKSIKK
The following text describes a protein:
Function:
Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity).
Sequence:
MLKIIQGALDTRELLKAYQEEACAKNFGAFCVFVGIVRKEDNIQGLSFDIYEALLKTWFEKWHHKAKDLGVVLKMAHSLGDVLIGQSSFLCVSMGKNRKNALELYENFIEDFKHNAPIWKYDLIHNKRIYAKERSHPLKGSGLLA
The following text describes a protein:
Function:
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
Sequence:
MASRQPFTDTDTADEAVRATCDDATVCKRFATSKGYWKDPYIQYFVRSVGERKAPEINRGYYARVQGVNFLLDAFLKKTQCNCQIINLGAGLDTTFWRLKDNNLMPRKFFEVDFPTIVSRKIHYIKTKPPLSKPIIETHSTDSLLLDAHSLDSDRYCIIGADLRNISDMEEKLKKFQLNTELPTLVLTECVLVYMTPSQSSGLIRWVAETFHSAMFINYEQANMCDRFGQVMIENLQRRQCMLAGVETCQSLDLQKERFLRSGWEHASALDMITVYSMLPQEDVGRIERLEFLDEGELLQQLLQHYSISWATKDKLRLGNLLRFFLQLLDLIYA
The following text describes a protein:
Function:
Required for normal structure and function of sensory cilia on amphid neurons, especially for the formation of distal ciliary structures, but is less important for normal assembly of middle and basal ciliary structures. Plays a role in the organization of axoneme microtubule bundles in sensory cilia. Required for normal structure and function of the ASER neuron that mediates attraction to NaCl. Required for normal chemotaxis to NaCl. Required for normal avoidance response to high osmolarity. In contrast, is not required for normal chemotaxis to isoamyl alcohol. Does not play a role in intraflagella transport (IFT). Promotes dauer formation in response to pheromones such as the ascarosides ascr#2, ascr#3, ascr#5, ascr#8 and icas#9.
Subcellular Localization:
Cell projection, cilium. Perikaryon. Cell projection, dendrite. Note=Detected in neuronal cell bodies, and to a lesser extent in dendrites. Detected in ASER cilia. Requires the intraflagella transport (IFT) machinery for normal location in cilia, but does not play a role in IFT itself.
Domain:
The TOG regions are composed of HEAT-type repeats that assemble into a solenoid structure. They mediate interaction with microtubules.
Sequence:
MTSLFDALSRSNDRLPSPNFLPEDFLELLKSNDFDTKLTTLIRAATIAKREEDWFHKFQKKGELFKCIDKIICDDRWELQHQCIKFLVEAMPTFGSATEYCMCFVMPNLIPKLVSNKVTVRKITHQAIATFLRLKPEALQSFLKMLSNFMPNCNSKSELITELHHILIPELVKSNWTCLVENFTTESNIQGCEDQAGVLMKKLHYFIGNEFWQKIITNLSPEKREVLEQITANVQVEHTESKAGSGVLRASAKPQSGGERRLRFGIVPSLVCALIAEDTDANQRISGLEKMKQVVDQITPEEIARLVPHLHSYLLMLSNVLEDLNFKVVVLALDIVRATGHHLKGHMEAHIQQFVNLVAKHFGNQKSVIKQIIMMTFMELFQNINPKTVGGCLRVFLENKNSRVREEVINIYTASLMTISPSKFNLQPLVNILVPMFHDVKKRVRLAAFEQLSVLAYLLNGKTEIIMKPVRDFEQDQNSRGLTEAVTARIRRQVLPRIRYDGLIEYSTPPMMDSFDLAEAEMSLPSNADLSWIVSNGGVEPDPFERTMSPISLAGNLATIRRNRVIQQQGQAEKPSFSLPQQPAQQASHQAQRLPNGIEKSHETSENSSLDIGQRIVMTRMKSDDSFVRRQGSAASNPNSSTSSWEAPKRPPISPSEKSSISATKKEVNNNHIVKKGNLKSMRARSDTNLSEDHGEEEMENDPPRSFDDRPAKASGQYSFQDFDAAIVPSSMGKKSISHHSLPITSHPPLKHAISQPQKRINNNGTFLRSGQGQRTKSVSKPHRELTAVSKTYSLLDTSNMSVNQALKKMSSDEWADKVDGLNMISTLSETQPRMVADNLKEVIIAILNECKNLRSSVSRVAIVTIGTVAQNLNSKIDSEMEKICAVLLSKSGDVSNAFIRDDATDSLNKLVKAATAGKALQGIILAGAKSKNNTIRSSCANFVYDIITIQGSSAILNNQNALSNVLPVLLQFSRDQSPQVRNPGKQSLCFLSKDPNFDRLMRKNALESEIKAVKDVLANVEKRGGVDSLESTANLSGSLSRIGSTRRVQKKLPDSLQLDLDEIRTELLAAGWERRLTGLQRFEEMCGHASKAVASDTRLIEAFISRLGDTNGKVASCAMETYISTMGSMAKLYSTESNLKAVMNQLAHALTAHLSSKSEEHKHLARTCIQHTIRSIEPVSLLPAMTSATKKSNVKQRPFILTQYCELSKLAYKSKPKQVEVMALPLLWDSVKNSAPDVDNKKATQYLAKTLAKLIGEKQLLDLATSELDPNRKKQLDALIR