lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MQVRTLLTLGKKKVIGNRQCILSLYRKYSNVQSRKAEDQLLRQIFDDQNIAVNQITKRNGIQGVGLFRNHFLSDKDTGFLRLAETASEKCKAVIEDLLLEDTEDGSIVVSKFDRISNLLCSVIDLFEFVRCAHPDKMVVMKAEEAYSYLFELMNTLNTHQGLYEKLKCSLQQTPTLKDTDPEAYTVGRVFLQDFEKSGVNLESSKRNSFVKKSSESATLGRAFFNNSMNRPQRYLTISKQRLAGSDPYFVRSLSKNDKNFIMIPTVGYEGTQALISVANPDVRKEIYMEGHKGTVEEVELLNSYLRSKAEVAKLVGKSSFADLQLIDKMANAPKHVVEFLENLSLKNSSVLKKILNNLALMKKKELNLNFLPSFDVWDREYYTARYKQSLINQKPSLNPSITNYRRFFSVGTVIQGLSRLFSSLYGLRFVPADISPGEVWHPDVNKVNVYNENDHVMGVIYFDLFARTGKTDGAAHFTIRSSRELDLTSFDDSISLGFDDATNIRVKDNKRYQIPVISLLCNFVRSSGMDPTFLDLWDVKTLFHEMGHAMHSILGHTKYQNLAGTRCATDFVELPSIIMEFFMSNPAVLPLYARYEGTEIPLPVQVLNHHNMVENSSAPLDLQSQICMAMVDQLFHSKVVLDPSFNSIDEVTNVTRKFSGFESAPPAAWYLQFSHLYGYSATYYSYIFDTVLASLIFSKLFAGNPLSREAGEKFRKAILRWGGSRSPWECVAEALEQPILATGGEEAMRRIGSEGIKATSTF
The following text describes a protein:
Function:
Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEGSLGDQIRQICVIILVVLFGSGSWLAINGLWVEMPVMVALGIPEGYNLASYLVIIIQLANIGPLAFTAISYFVKGNKLEVPTIYLTLSAGVLACLLLVFFWDATTIWGVFGEPRSTALICLSFILALANCTSSVTFIPFMVKLKSSYMTWFFVGQGFSALAPSLVALGQGVGQQVCIANYTFTHQSTGENCTSWTSQTQPAKFSPETFFSFLSAFMFLSFTAFLFLHTLPSSKKEYAQQDVETKSSPEKYTESKYGATEINEEDKQNSSEKIEEEPSPQRQSHSKGEYAILFVILAIANALSNSVLPSIQSFSCGAYGFNAYLLAATLCQVANPVACFIVLFFPHTSLVLVAGTCLLGLLTGGYCMATALLSPTPPLQEEVSGIVLVVIAWILAGGLFAHVKATIGLILRNEPDNHRLLTWYGVVTQFGSMAGALIIFPFVNVLSVFVPYYSDPCEGYPVCE
The following text describes a protein:
Function:
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
Subcellular Localization:
Cytoplasm.
Sequence:
MIAVAGKRVLVMGLGVHGGGLGVARWLLRHGAEVTVTDLASAEMLAEPKAQLDAFAAEIGKQVRYTLGEHRAEDIQAADLLVVNPAVRPDSPWLALARSHGVSIETEMTLFFRACPGPILGVTGTKGKTTTTLMLAAMVRQRYPDAVVAGNLRISALEALAQIGPQTPVVLELSSFQLERLGEAGLSPDYALLTNLGIDHLNWHGSFAAYANAKRQIMAHQDEDGIAVLPPEQAKTWGRGRRGIISFSLSDPTADATVDADGYLRYRDVILAHHSDLRLPGTHNLANALAAATLAYHFGIEPHEIVAALQSMTAVEHRLELVATIDGVRYINDTTATNPSATAAALATVAGPIVLIAGGADKDLDLAYLADTIAQGAAAVVLLQGSATPRLQTLLSQCAPQLPLAGPFADLSTAVATARSLAQPGGAILLSPGCASFGMFRNEFHRGEAFRQIVRELAGGRAGEQKYDPST
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWHVTNISDLAKIIFIFWKFSGLPVFHSENSIGDRKNSYFFWLILFLQVAFCGLYMTFIVLPHNFNDYVGFLQLAVLYFHNFVLILHFWRKRKGLVFTFSKILVLERTVLYFTRKKLNCDKITKFLICYKALQFSVTLGVFISSLCLTTRTTEGIVFNLCNFLGSFLAFNFETLLLFFLSVLNELYLQFNCGLKRSLSYFQVLKVYFLLQEAINDVIKLLQIQLLLKVSSDWVITISTLFYVLKQLQNHSLPSENLLILVAVIWPAFILMSTFLMAFYCEKIEQQENTMANILTQVKIVPSYKRLNLLALRLEIKPIRFTIYELCPLNCTFINMMIVGMATYLIYLFQFSQMKQIG
The following text describes a protein:
Function:
Involved in uptake of vitellogenin by endocytosis. Expression is regulated by the juvenile hormone analog, methoprene (in vitro).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MRFIVLLFICSFIYPCYVSSIGFRRISKVSLKKTKCEDGYFQCNSGECIPVDKKCDYIDHCIDGSDEDFECDHLDEKSFITCAKDQFKCKNQECIPAAKYCDMVNDCLDESDEHDGCVKHLNCTNKFLCTDGHCINKEWVCDGRNDCPDGNDEWNCKANKTSSASSCKTENYQYMCANHRCISLKVVCDKKDDCGDGSDEGPGCTQFNCSSAGCQSNCHQTPKGSVCTCKPGYKLQKDNRTCNDIDECQAYGICDQDCMNVPGSYACTCQREYYLENDKRTCKARAGEATLVFSTRTSILGMHVDSEKFFSLATNLNHAVGVAMYGDYVYWSNLEENGYNTIVKKRTYHPQAPNEVIVTTGLALITGIDVDWITKNIYFADEDNHCIGVCTNDGTYCTVLIKDTDKPTGVALLPTQGKMYWSDWGTFPHIAVAGMDGKNVRIFVNVKLEWPKSVTIDYPNERLYWVDAKSKMIESVRLDGTDRRIVLHDIIQEPFSMTVFQNKLYWSDWESNGIQTCNKFTGKDWKILIRNHNKPYSVHMDHSAIKPNIDNPCYSNPCSQLCMLNQNKGYTCGCTLDKKLNADKHTCQDVKKNQHLLIIQGRKFINYYHEFLGKPKVMTLSLQHMSQQSYNNLVNIISDPLSGQIIICHLQLSTPFLTSTTDILRYDPVHHSSEKIVTINKIFFELAFDYIGNNLYTTNTVNQSIEVINLNTKAMTAFYFKDEVPKYIALAPEESKMFVAFQKSMHSISGLTLYEMQMNGLGKRKLIREGLIGPQLPMYYDRDSKTLFVSDLLPGYIYSHSAQDTRILRSGLKSPHSLTVAGDNLFWIESQNKLYSTNFRTASVKQKTVEFDLSKLNDNMTSLPGHLTPYSRDAQYVVTLRKDDIPKHDCQKNNGNCSHVCLPSLITSFICACPPGMELSNDNRTCISHHECSKNEYKCSEHNICIQRNQLCDGIENCPNGEDETSECRIKGRCKENQFMCKNGDCIRLKDRCNSRYDCTDQSDEQNCEKPKCKSDEFQCKFTETCIPKTKMCDSNPDCDDLSDEEDCRKVECTSNEFKCNNGKCIPNTFVCDNDNDCEDGEDEAAEKCYSKIACKMPKMFKCPNGDCISDSLLCNGINDCNDGSDEVHCLSNVTTHLVNCSLNEYRCLGTDICLPKNVRCDGKNDCPQSDDEQNCTYCFENEFACDNKRCIPELWVCDKANDCGDNSDEKNCDGSKRNFIESNECDEFKCSVGTCLPYSKVCDGNRDCPDGSDETGKCQTACTVNNFCKGMCYKTPAGAVCGCQSGYRLAVDMISCEDINECELDICSQMCRNTIGSYECFCKDEFIIRNDKTSCKAVGPAMEFITVTDNDIRKMTHNLHSTTQLLFPLMGVRVSGLDVNAVSDSVYWSNDEFGTIKKLNIRTNEIVTVKIVEHPQALAVDWITGNVYVNDNSHLNTIKVCNLEKGKCATLVKIQDKMKVASVIVDSINRWLFWAEISLEADHPTSKICRTDMTGADMKIIASDLGFVRGMTIDHVKSKLYWSDDFYKTVESSNFDGSQRKVVLTLNMNHALSISIFEQSLYFLSSDNLLSSCKMYGKRSCEHVNIGANNVFRLFSILHISRQVPFANPCDAEYCDYMCVLKKENATCICSDGESIESNSTCNIKNDLKFVESINFSRNTRNISGIYSITIIVLLVSVLLLCVYYYYQKNKLKSKPASNLSCSSIHFQNPSYDRSDEIEVMLDSMASSELSPGQHEYINPINNKGMKAAENNAKKSNQCSEGKNIEEEKQDALIYFVHNSK
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MEGPVLTESEVWKVGSETSTSINPEDRSIDYPLINDTDEKVKAPESAVQEEIIQQSVNPPELRIEDLSSPQTEMEVDDPACKERCKEMCIDQEITILVTNHDCNLEEEEDEDTNEEQTACTEAVISSVDVRELIDEDNLDGSIVVANMIEVSQIQKTNVVNNTSTNTTTEEQPKSQEDPDPICTKSNPPQESDVCSTQSLKDQPTQSEDVGKVDANKSEPAKEKLDLSRSPIRTQHVQTQVSLEVMYHSVATSPMTPPEASGTFIFPSTFGKLANKCNQEDLETKNVEMHSVATAPMTPLVLNAPETHSVATAPMTPLVLNAPELHSIGTAPMTPTVLNAPEMHSTGTAPMTPTVLNAPEMHSTGTAPMTPTVLNAPEMHSIGTAPMTPIVLNAPEMCSVATAPMTPVILTAPEVIPEPEPRIGIVIEDSPEPVQEVSWDEKGMTWEVYGAVVEVAVLGTAIQKHLEKQVKKQKIQPGPIDVPCVDLSEISTPMPSSPPPISGSAENIQDKGESEEKPVQIKRRRQNHVRQWFRSIRRPSCCSRPRQDEE
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPQM that catalyzes unidirectional Na(+)-dependent sialic acid uptake.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MELKMLRKIINNIEEIITVPLMAALLAVLTWQIGTRWLLNDPSLWSEELARLLFMYMCLVGCAIAIKRSSHVNITFFSDKLPEKARLSLVLSLEIAVLVSIGAIIVLGYQHAQRNAFFELITLGISSSWMNYSLPVGGVFMVFRQLEKIFNLMKLLLGVSSSASLIDQQVTER
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MFAVPGWSVSSSLLKTQTAESVAAAPKAEEEGVPVETKSSKKRKRAKNPDVNAANLSELWESVIEGKPKTKKVKNAEKDGEAKEKKDKVVKEISTDDIQNGPAGPSNDSTETSESKKEKKQKKKKKDKDSKPSDNDQPMKDDTADATSTKPPKPIAKLTPLQASMRQKLISARFRHLNQSLYTTPSSESLATFQQNPEMFTEYHEGFRRQVEVWPENPVDGYSLQIRQRGKLRRDMRGQPAQEKTDLTPLPRTDGTCRIADLGCGDAALSTGLQKDLKKLNLKIHSFDLQSPSPLVTRADIANLPLEDGSIDIAIFCLALMGTNWIDFIEEAFRVLRWKGELWIAEIKSRFGRVGGSNKKVVEHSVGHRKKNQPINKKAIKAADDEADEADLMVHVDGNEDNKQETDVSAFVEVLKKRGFVLQTEKSVDLSNKMFVKMHFVKGATPIKGKCVPIAKGVPTGETWKKKPKAKFLEEPEDVDVSNEAAVLKPCVYKLR
The following text describes a protein:
Function:
Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
Subcellular Localization:
Cytoplasm.
Sequence:
MLILVANLGSTSFKYKLLDMSGDFESANASPDSRVLARGAVDRIGEPISQCEVIVTQSHQGETFREETQMPVPDHGVAVQACLDQLTHPENGCLTEANEVAAIGFKAVHGGRKSGTFVVDDEVLEAMDEMSAAAPAHNPPYIAAMKLLRQRFPELPLVAAFETEFHDTISPERRTYAIPAEWTREMQIQKWGFHGSSHRFIAERAAEVLGRDDAKIISCHLGGSSSLTAIDSGKSIMTTMGMTPQTGVPQNNRVGDFDAFAIPLIMERTSQSLEEVLKTLASQGGLKGLSGGMADLRDIESAASEGNADAKLALGVYTEEIRRHLGGMMVALGRLDAIVFTGGIGENSDVVRAAVCAGLEGFGIELDASKNDGMRGEGSLHTESSKTQILVLPTNEEWIVAKRSLRALAAQ
The following text describes a protein:
Function:
Palmitoyl acyltransferase.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MGFVYYVTLFVFIDDWVGLQSSAGKLNALLFSLLASLCLFSLSICVLVDPGRVPASYAPDVEDSGWSNSNVTETRKCDKCFAYKPLRTHHCRVCRRCVLKMDHHCLWINNCVGYANYKAFFILVFYATVASIYSTVLLVCCAFKNGDSYAGNVPLKTFIVSCGIFMIGLSITLGTLLCWHIYLITHNMTTIEHYDSKRASWLARKSGQSYRHQFDVGFYKNLTSVLGPNMIKWLCPTFTRNPEDGISFSASRDS
The following text describes a protein:
Function:
Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance.
Subcellular Localization:
Mitochondrion.
Sequence:
MLLTLSHNLATSKLYHRIKNYSSPKIILSWICNIRYCTVPKIQYPFKPNSKVEQSNIDDPLQFTRPICITLPKQKSHNGDVTYTDEENKLASVTTILKNSMSYGDYIRIQKWKQKAQLQLGHLEYHKTSTTTNVSVDEEEKVATAKLDKLKDKEYGGSNWAELVEQTHLLTTTRLDVLENEMGEQGLPAELTPEQEKLVQSLGKNELRKYVDLIRKRGHSLHELIRDYLSDKELIDYFKTTEYWHSVSHVLDEVTQVHALESCVWHSNLGYAGTVDAVAQFRGETCVFDWKTSKNPKLSIFDCYDYPYQAVAYAGAINQDFNYPFQVDSVAIVIVYNDGQPATVIRITADDCQLIWEHWLIRLQMYKLNCQLKQLSNDRVNYFSDNYWHRKALKENKIEIKVMDLSGSGDRVQETNSSSQLLSEIRILQGKLDENKAKIKERFRVSKPRRRPKLQ
The following text describes a protein:
Function:
Response regulator that coordinately controls the stress activated wak1-wis1-sty1 MAP kinase pathway and fission yeast cell cycle.
Subcellular Localization:
Cytoplasm.
Sequence:
MRIWFKKVPDGITSSVILSEDHLVDDLKDAIARKFPIRISQYYDAPELSIRVVAPPNASSELQSRELSPNESILFVMETYYPHGQDFNDALLVASPDTSVALRYRSSQLSSSTFESTPPVFSEYPPNIIPTPANETVPRIKQPSIALDSLESPVSAPSRHQSTYSYKGGPLNYNLRNASRTRSHQTLPSSNVNKTGVLLLPRSSRQQTLASRPSLPDLTSADKSQPSDEAESITRKNSIGMSTRSDESTAEKLAKAEVATPTNSRSISHSSLYTKQSGTAGVLPAVNADIDAANRMNPDISSQFPIADNKDPLNADTQAHLGFPSNQIDGIVGTSPVNVLTSPGIGAKAPFASLLEGVIPPINVLIVEDNIINQKILETFMKKRNISSEVAKDGLEALEKWKKKSFHLILMDIQLPTMSGIEVTQEIRRLERLNAIGVGAPKLTQPIPEKDQLNENKFQSPVIIVALTASSLMADRNEALAAGCNDFLTKPVSLVWLEKKITEWGCMQALIDWNGWCRFRGR
The following text describes a protein:
Function:
Orphan receptor.
Miscellaneous:
MISCELLANEOUS: Most adhesion GPCRs undergo autoproteolysis at the GPS region of the GAIN-B domain. ADGRF2 is not autoproteolyzed at the GPS region because of the lack of a consensus catalytic triad sequence within GAIN-B domain.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKPWIAMVCCLVFFLTTECSHSKPKTHRKDEDKFQISLQKHEFRPRQGKCDGLCSSSSSCNQSCPWNFRGEIVFTCNQNKWQKTIETCTSLSVDTLFQRIHPAASLSLASSSVFPMSLIGNAAPVHIGNVFQGIQKYCPEDYVCIVDAVKSSAVTSGNIAFIVELLKNISSNLQTSGIHDNVNWKKMKNYGKVANHILGPTAISNWAFIANKNASSDLLESVNSFAKKLQIQGKSESIVDELFIQTKGSRISHSSSEHSLSLSVPRYNATEDVLVVIEIPRQALQELSFNASQAIVVAFPTLGAILKEVHRPNTSLQKPIDDLILSLVLPEGLNEIILTFDKINKSQSTSSQCVSWDPATGQWDESPCTVMSDINSTVKCRCRHTKAVTSFSILMSSKPVKNTILNHITFIGLSISIFSLVLCLVIEAIVWSRVVVTEISYMRHVCIVNIAVSLLTANVWFIIGSNFSANVQEDHKWCVAVTFLCHFFFLSLFFWMLFKALLIVYGILVVFRRMMKSRMMAIGFAIGYGCPLVIAVITVTVTEPGEGYTRKDACWLNWNQTKALFAFAIPALAIVAVNLLVVLAVAINTQRPLIGSSKSQDMAIVFRISKNVAILTPLLGLTWGFGLTTLLEGVHLVFHIIFALLNAFQGFFILLFGTIMDHKIRDALRMRVSSLKGKSRAAEKVSLSPANGSRILNR
The following text describes a protein:
Function:
Possible transcription activator.
Subcellular Localization:
Nucleus.
Sequence:
MGRKPCCEKVGLRRGPWTSEEDQKLVSHITNNGLSCWRAIPKLAGLLRCGKSCRLRWTNYLRPDLKRGIFSEAEENLILDLHATLGNRWSRIAAQLPGRTDNEIKNYWNTRLKKRLRSQGLDPNTHLPLEDSKLDDTEDDTDDEGGDSSDVTMSDASKSEKRSKKKSKPKETVKVRQPKGPKPAPQLKMCQSDEGPVLLKVPKAPKSPISVNPGPGCNYDDDSEHSSSSTVTTKSHEDHRDSSDFIKALTSVSSFPEAELWSCIKPITNSFSSTALLSEWDSYRAFDSSLFPSSYPQLNSGLPKLEDVNSKSSAVASPVQGMLPAYNPMGMEMQTRMQFSSQLTHEIGQNYGGIFQETCYPQPDMGMSWSMHAELSHCGTESLFATPNPANAPSNFEEVPQPSPCTTSQELQRLAALLDLI
The following text describes a protein:
Function:
Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Sequence:
MFSSSMFPHLILPAIGSSKVRTMVLPFAFVGFFIFPICLASLLDWNDAYEYPKYSFEWSNVSILEGDIDSIKEKTEKTKLSSLFYAGKHEYFCVYPNASLIKQNSTTEPSYDLQELRIQGTEKINELANVFLIENRGYWTYDYVYGQHVRQYHLEPQQGSDKVLANPMYILGTAPNTQTKKNLEENWAIGFVEGKAYLQTTFRNGTMCDITKRPRHVILSYECSTNSDTPEITQYQEVSSCAYSMTIHVPGLCSLPAFKIQEDIPSEKIVCYNVIKEKSNEVDHKDSQHVVDEVAQTSPPEVKEVETQSS
The following text describes a protein:
Function:
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.
Subcellular Localization:
Nucleus.
Sequence:
MTKRSLENVSDNDSNDLHPLASSDESLIVRKQNALKKFHHPYIPYSIQLDFMKTLFDVIENGNIGIFESPTGTGKSLSLLCGALTWLDERGSMGLCSQGETELQTGTTAVSDKKHGDTHADDDGLPDWVISQGAGLQKETVEQAHAELETRLEAIRKERCMKQSLSRRKRFRRGPGPTENSVKDSGLERSSASLEEDLLVQDDTFADGNMFTEDVSRLLRLLQPSDGTLPQVQKIYFASRTHSQLQQFLDEVRKLDMTTFTTPVRAISLASRKNLCINENVKRLGSAALINEKCIEIQGNCPFLQATTPIDDFRDAVLAEVMDMEDMITLGEQTQTCPYYGIREAIAPAHIVAVPYAMLLQQSTRDSLGISLRDNVCILDEAHNVIDSICSILSASVSQTEVLLCQKQLQCYLQRFAKRLSGPNRMHIQQLLRIVDELLHVFERLAGQEACTIDPATLFIAHGTDQINLHRLTQYISASKIARKANTFHVKNTLEAEDADHSRHAVPTGTPVIMKLATFLTAIANPSPEGRLFYRMESVEETVQGHNSKAVLEYALLDPSHEIAALAEQARSVILAGGTMSPMDEIAQLLFPSFLDRVKQFSCGHIVPESNICTVVLSKGTGGTPFRFTYKNRGDVNALQDLGRTMLNLTAVIPDGVVVFFCSFRHLSEAISCWKKSDLWLRLCKRKPIFYEDKEREALAGDGSKKSVFEDYCASVTAGKGGLLLSVINGRLSEGINFSDRLGRCVAVVGMPFPNAQDVRWQAKMSFVKEKMSSKTEKGIDLDYEFAENTCMRAANQSIGRAIRHKDDYACILLLDERYNKPSTQAKLPKWLANNITHAQSFGVAMRQIAQFFRGKKTN
The following text describes a protein:
Function:
Required for KRAS signaling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases. Required for lymphocyte development and function. Not required for myeloid cell development.
Sequence:
MASIDIDKVRIIVIGDSGVGKTSLIHTLCHGEPIINPTWTIGCSVDVKLHEYREGTSAQKTFFVELWDVGGSSGHKNTRSVFYTPAHGIILVHDLTNRKSEGNLRKWLAEVLTKECNGNTLSSVRTVNPSRNQDIDEYDPEQFIGSSQIPILVVGTKLDLAEEVRTHFNRRLSPIAEECGAGEIFVDCTTAKAMAPGSSSSVKLSRFFDLVIEKRFYNRDRPSPFTDKRRLMSGYSGNTINHKTFHFE
The following text describes a protein:
Function:
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Cell membrane. Nucleus. Cytoplasm.
Sequence:
MGNHLTEMAPTTSFLPHFQALHVVVIGLDSAGKTSLLYRLKFKEFVQSIPTKGFNTEKIRVPLGGSRGITFQVWDVGGQEKLRPLWRSYTRRTDGLVFVVDAAEAERLEEAKVELHRISRASDNQGVPVLVLANKQDQPGALSAAEVEKRLAVRELATATLTHVQGCSAVDGLGLQPGLERLYEMILKRKKAARAGKKRR
The following text describes a protein:
Function:
Initiates apoptosis in a BH3-independent mechanism possibly by recruiting ced-3 to mitochondria and other cytoplasmic membranes. Has a role in lifespan and tumor growth (By similarity).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MLDIKKKINFANVSGEKTDESSSSSAQQSSEQQQAAQPLAPQQTTPTAKATNPFITPMTESTPGMSESWVELAPSRTSLCSSVDINMVIIDEKDKDSRLSPVSIAQSPHVEFESLEQVKYKLVREMLPPGKNTDWMWDWSSRPENTPPKTIRMVQYGSNLTTPPNSPEPEMSQYMPYESDSLFNVRVVFGFLVTNIFSFVVGAAVGFAVCRKIIKHHRHY
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDQSQRTVAATPSSSRSYQFHPARAAIIDLFNLYLGRGSRQKPDESLRDPPNKSQKRVHAPNRDLPPRNEQFLLDFELLQSQFNDPEQLRTITESVLISLVVQCSNHAPRAEFLLFALRTLCRISYINWDTFLPSLLSSVSAAEASLSQGVQAAAATAGSSATSSQSVVPVSVNPTSLLPSAHGIGSPSASEVKSVENGQQIARAGQIVRENAMRNSQRIRAAAVNSLRQLSCKIILIGVESSLKPVTHAEIFQYMMNWLVNWDRRDLGTEDSVGKSWRSEKTLAEWLRSCLDVIWLLVEEGESRIPFYELLRSGLQFIENIPDDEALFTLIMEIHRRRDAMAMHMLMLDQHLHCPSFGTHRIVSQITANVPPEAVPHLRHSPITYPSVLGEPLYGEDLAMSIPKGSLDWERAVRCIRHAIRTTPSPDWWKRVLVVAPCYRPSTQAGPIPGAVFTSDMICEAIIDRIVELLKLTNSGNDCFGIDLVSVTFPPLYADANCWQEWLVFSDIFFFLIKSGCTDFVDFIDKLVLRLNGVDNHILRTNHVTWLLAQIIRVELVMTALNSDAKKVETTRKILSFHREDRNSDPNNPQSVLLDFVSSCQNLRIWSLSTTTRAYLNNEQLLKGKQIDEWWRSKGERMMDYMNMDDRSIGMFWVVSYTMAQPACETVINWLSSAGMAELPGLQPNDRVMMTQEVTPLPMSLLSGFSMNLCLKLALQMEEALFVSQVVPSIAMVETYTRLLLISPHSMFRSHFSQLAQRNASLLSKPGVTLLVLEILNYRLLPLYRYQGKSKTLMYDVTKIISALKGKRGDHRIFRLAENLCMNLILSLRDFFSVKREGKGPTEFTETLNRITIMTLAITIKTRGIADPDHMVYLQTMLEQILATSQHTWSEKTMRHFPSLLRETLKGRVDKRGLSIQAWQQAETTVINQCTQLLSPSAEPAYVSTYLSHSFPQHRQYLCAGACLLMQGHAENINSTNLARVLREVSPEEVTANIYTLVDVLLHHVHVDLQQGQSLEAVLDKAGANLAFFFWTHEMLPLDIFLLALIDRDDDPHALIIAMSLLKTPDLLLRIKNYCQNRGSPEHWLVTQVFKRNELQKALGNHLSWKDRYPTFFDDIAARLLPVIPLVLYRLIENNAMEQADNLLLAHSHFLAYHPLRFTFVRDILAYFYGHLPGKLVLRMLKVLDLSKIPFSESFPQYISPTGAPVCPPLDYFASLLLNLVNNVIPPLSSSSNCSSRSGSMADILNSSARPPHGKTPGTSQPGPANASEGQKAFYQIQDPGTYTQLVLETAVIEILSLPVSAAQIVSSLVQIIVNIQSTLIQSGNGFHGAANGVGQGSVLPTSPSGGSTDSMSASRSTCLIPGINTASFVSRSGYTCQQLSCLLIQACGLLLAQLPPDFHVQLYLEAARVTRETWWLKDGKRSQGELDSAVGYALMDPTWAAQDNTSTAIGNIVALLHAFFSNLPQEWLDGTNAIITNLRPVTSVAMLRVVFRIMGPLLPRLASTHTLFNKTLMLLLSALVDVFGKTAQTTAPVEASQIADLIDFLHHIIHYEGQGGAVQTSSKPRPDILALIGRAAETLRPDVQHLLAHLKTNPNSSIYAAAHQQNTAKTNTS
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSKILKIQYLKLYNVISCFLWMSVLLRTGLIWGITKDTAVVFHETNTLVRWVQTLAIAEVFHSIFGLVSSSPLTTIIQVASRLYLVWGVCYPFSYVIEGSPIYLSMIIAWSITEIIRYAFYAFNLNGDIPAFLTWLRYNTFLILYPIGAGSEFLLVLKSRIAAQYVWSLNKLLWPILMSIYPPGLYIMYTHMLAQRRKISKRAAARRT
The following text describes a protein:
Function:
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMVVAALLSWFLLGLFIHYSKKFGWGQPIRQDGPQTHLAKEGTPTAGGVAFVLALLLVFVGLLAFGGIGQANLSREVMILLAALGMGVVGGIDDFLKIRSRKFGGKKELLAREKFPLQVLVALLFAGFAAPLASHQLLPGFMSIGGYPIFDMLFIAFVMVGSVNAFNFTDGLDGLLAGVGMIVLLPLVAVSPIAALMVAVLLGFLWFNAHPARVFMGDMGSHAIGAVAAGAYALYSDVWLLPIAAIIPVAAVLSVVIQVASVRLRKRKVFKMSPIQHHFELSGWPETHVTLRFWVVTGIATALTWWLMGGRP
The following text describes a protein:
Function:
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MIRLAVIRLAQGASRAQFLQKQAQIFTSAVVNAKKKADNKKKNPPAVFSNLEENAVVQETIKEIQRVEGLLVEELTRHFSLKVDIRQYEDVMVKLENGKDKPLSMIARVTLKSPLMIMINFQDNPSAIKAAKLAIQKSTLNVTPQQEGAVLYVNVPPMSKERREKMASDAKGRILNEYKKAINEIYSKSDKKSSNEFSTRPDEAKKTREALLNMKHAAEQRGGLLIEERRKQLLKQVV
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSCRPFLGSAGRAHGGVSTGKRCPLKAGTERRAAGPGLTRTRGLRRDPPAFSARLLARQALAELMTLNLLWPPEGSRGAVLLALAARGSVTFRDVAVDFSGDEWGFLSPAQRELYWDVMLENFKNLLFLGLLDPEPNLLSCSEGREDLQIWHLQGGVLGSTCSCKAWCSNRRNGAGAWAHPAAHMGVEIGRRPQKPSNHTWPRCPTAPRPTTWASELGKRESPQNIDGCASPVTGERYRRDVLQKEIFVKGFVQGTELWKQVGNISKATPKKFISQGTNLIQLNALSETTSTGQGSLDNLKQAICKHSGSWNYNECQVLSHCHSSFHKYQPVHKEKESSNCEDCAMAFSNNSDITRYQRIHTTEKEYWKAFNCSSAYTKCENIDSGEKLYKCKECWKALRQNSAFIKCHGVHTGERCGKVFNQSSSLTQHHRIHTKEKPHEYKAHGEVFSQNVIFTEHEIMHSGKKINECKECGKTFSRNSSLIQHQRIHTGEKPYICKECGKAFRQYSHVIQHQRIHTGEKPYVCQQCGNAFSWSSAFTEHQRIHTGEKPYKCKECGKAFRQHSHVIQHQRTHSGEKRYKCKECGKAFRNSSDLIKHKIIHSGEKPYACKECGKFFRQNSHLTQHKKIHTRMKLYESKARGKPFNHNPNLIKHEVTYKEKLPFDCKKCGKAFRHNSQLIGHLRIHTGEKPFECKECRKAFRLNATLTEHQRIHTGEKPYECKECGKAFSQNSSLTKHQRIHTGEKPYECKECGKTFRNKSNLIKHKIVHSRERPYKCKECESTFRQNSYLIQHQRIHGQGQLHGNKECKYTFCQSVALTEHKKIPTSDKPYIYLKQGL
The following text describes a protein:
Function:
Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons). May be involved in the maintenance of osteochondroprogenitor cells pool.
Subcellular Localization:
Secreted.
Sequence:
MKVKGKGLPHLLASLVSVCLATLPYGSACPRRCACYIPTEVHCTFRYLTAIPDSIPVNAERINLGYNSLTKLTETDFTGLHKLELLMLHSNEIRVISDKTFTDLYALQVLKMSYNKVRRLHRDTFHGLRNLTRLHLDHNHLEFINPETFYGLTSLRLVHLEGNLLTQLHPNTFVSMSYLQIFKISFIKYIYLSDNFLTTIPQEMILYMTQLESIYLHGNPWVCDCELSWLPDWIQQHPDTFKCKKERNASTFLQCPLCTNPKNYKGKRLAEISAEALSCMKPTIDSSLKIKNLTIPEEGDSVTLLSKDFVAPLGLIVMNLTDQSGNEANLACSIQKPSKPLPISLAEESGYITLNTSFSTFLVCNIDHHHIQPLWRILAMYSDSPLRLERVLSLTQTPHLSQKYNQITARSEDIFTDIKAELRADPSWLMQDHISLQLDRTVTTLSTLHIQYLADAHVTVPREKGPIKHKWTMISRDNTTKLERTVLVGGTTELDCPAQGDPSPRLEWVLADGSKVRAPYISEDGRILIDKAGKLELQTADGFDTGLYHCISTNYDDADILTYRVTVVDPNEGSYHVNGAPHMSSIGETLELPCQSAGIPDASFSWVLPGNIVLHHSLGNKQILSDGTLRILKVTEQDSGYFRCVAANPYGVDFLNFQVLVDTKGHIPEYQDGEAEGSGQEEPKTITTNPKEPPVVQNTVTPEADVTNPSKRKNYSELTYRRHGEAISRRFREHRRQFPPSARRLDPRQWAAFLEKAKKLATPEKVGSAITTLPTQVTPLSKLSADGEESSGILPPDEEFMLLTTRAMEISVSPVTTDPITPSSSSETSISPDMEAFPIVSPQTLQHERPAKFISNTNLNLSTSIKTVPVSTQINLNTSGRMADIITRQLPTTSSLMPITVKILSEDQSLWERNEHSKSISTTSKDGVKDSNISISEDTDSKDLIFRDSINELSHQHMSVITENKSNNGNFYSQTTIKSHNSKFPTDSTILMQNPVWAIGDVTTTTPLMRHYGRRRKIWGRRRIINPGRIPNTRGQRYPFLRPRFKFLPEERTTLLPKELDMKCPTCTPGMVLTTAPSHFFLPSAVHDPLPKMNFAEVTLAPTTPYPHPASQLEEVDKPNVESEKTTPTIRYFSAESSHVIPKNELVTLAPMPLDTEKTLPMSTSHPALFSTTPSASVTKKGAPIPTTRSSVIAISSAPSVTAFTRAIRRKIPWHQIFVNKYVQTEVRKDFHKSSSQANTITVPPKMSPVVPIDGGSFHFTTLLSKEMQIPTITQKLTSIPDGANPENLPTMTDLPSLAASTTTISTTVSFMSTHSPHIVQPSTTVIRNRIARPGRRRGQRRRRPQKNIMTPRTITEVDNAITTSSVMTTTPSKMVVQPLISSSTFTVTLSPEGIKEIPTSNSFHPLTFNATGVNEVFKINSLVPSKTTEVNMTSSSKTLQGTFTSKTPFLRISSGMEVPEVPSIPLTRSEVTDQVPITFLGTIAPNEPKPHEATSFHIDQHMSGPETEAPSRSYPQTESSFRTTPSIYADIYPTPALLLTTVEPQSSKDNVTPLWSENLFWHQSYSEVAERGKIPGANVLTTINFPESITQHTPKWEDQQENVIKSSLDQIAVQETTTAKHLTFGYLSRNRFEKPKIVGGKAASFTVLANSDAFLPCEATGNPLPTIHWTRVSSGIVLSEETQESRFEVFSNGTLFIQNVNIQDRGQYLCVAANQHGSDRLHVTLSVIAYPPRILEGRTKEITAHSGSSVEVKCRAEGRPTPKISWILANQTMVSESFQGNNQALVKPDGTLVINTLTVYDRGIYTCMANNPAGMDSWLVKIQVIAAPPIILEQKRQFITGIWGENLKLPCTAQGNPQPSVHWVLLDGTEVKPLQFINAKWFLFPNGTLYIRNIASSDRGNYECIATSSTGSERRVVNLIIEERDTIPRIETASQKLTELNFGDKLLLNCSATGEPKPKIIWRLPSKAIVDQWHRMGSRIHVYPNGSLLIEAVTEKDAGDYLCVARNKMGDDLILMKVSLRMKPAKIDHKQHFKKQVLYGKDFQVDCKASGSPVPEISWSLPDGTMVNNVMQADDGRRRSRRYILFDNGTLYFNKVGIAEEGDYTCYAQNTLGKDEMKVHLTVVTASPRIRQSHKTYVRVTAGETAILVCEVIGEPRPQIFWLLPSNDIISSSTDRYLLHDNGSLSISKVKLLDSGEYMCVARNPSGDDTRLYRLDVVSKLPLINGLYSNKTVIRATAVRHSKKYLDCRAEGTPPPQIMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLTDTADFICIVRNDGGESILVVQLKVLEMLRRPTFRNPFNEKIVAQPGKPLALNCSVDGNPPPEIIWLLPNGTRFSGGTSNSRYQLGRNGSLIIMKPTRDDAGKYRCTARNQVGYIEKLIILEIGQKPVILTYVLGMIKGITGESVTLHCMSDGSPKPNIIWTVPSGHVIDRPQMNGKYILHENGTLVIPKATPHDRGSYACKAQNTIGEAVITIPVMIVAYPPRITNRPPRNVRTLTGAAIQLHCVALGIPKPEVTWEMPDHSVLSAAKKVRSTGSELLRPQGTLILQNPKTSDSGMYTCTAKNPLGSDYATTYVQVI
The following text describes a protein:
Function:
This protein binds to 23S rRNA in the presence of protein L20.
Sequence:
MYAIVEINGQQFKAEAGQKLFVHHIEGAENGSTVEFEKVLLVDKDGNVTVGAPTVEGAKVVCQVISNLVKGDKVLVFHKKRRKGYRKLNGHRQQFTELTITEVVA