lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Receptor for members of the ephrin family (By similarity). Receptor for major sperm proteins (MSPs), that functions as a sperm-sensing checkpoint which inhibits oocyte meiotic maturation and ovulation when sperm are not available for fertilization. Specifically, functions to negatively regulates oocyte maturation and MAPK activation in the absence of MSPs. Required for the MSP-mediated increase in the basal sheath cell contraction rate in somatic cells. Phosphorylates phosphatase daf-18/PTEN which probably promotes daf-18 degradation. By inactivating daf-18, positively regulates insulin-like daf-2 signaling cascade. Involved in interactions between neuronal substrate cells and a migrating epithelial sheet in head epidermis morphogenesis. Also required for cell movements following gastrulation and during ventral closure of the epidermis. Might play a role in spermatheca morphogenesis. Involved in axon guidance of SDQL neurons during neurogenesis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRLYNSRILNPHQSIFILVLQCLITIVTSHQEVLFDLSKVGSDLKWDQVSLRHDRDDVWMEETWRNPAATDEKHANQRAYVTCNYDMINPSNWLFSHFIEVKTARRIYIELLFNTRDCDAYLNPKSCKETFSVYLKQFKTSRPGSTKIEKERFSEDIDNWKNIGRLARSNSNMTTETLGMEIDSDTKTIRIAFEEQGICLSLLNVKIYYRICDEFTDQLVYFRPQVTGPKETDMVRMNGSCIPNASKKIPGVDLIGLCMSTGSGIKTSGECVCDSGYSQIADSNGARCESCPTNTYKPKGQSLCKSCPSNSISSEAASSCRCLNGYFRAEDELISMPCTQPPSRPIKLVANAITATSTRLSWNEPSSLGGRPEIWYEVKCSGRGECGTVVMTPGDKKLSTRSVQINGLRPSSDYTFLVFAKNKVSAQFPEFSEKNAVIDIRTRSEEEDVPPVSHLRVDASQSDGITIAWSVSDSDVSDFEVEVRPAIVKKRTFETRHVNMTYTTFIGLNPETVYQFRVRIRDDLRWSQPISYQLGRGLMSSPSSNEVEESQFLNQTGSALLIIIALILIVIAVALCMIVVQKKSKNRKQMSDLDVLDTYKQDSMTPDYHTTSRHHHHQGNLPATLHEQLRSTTKLNAPLIPSFGSPISQPPPYYGGVHPNSGKYKTYVDPTTYEDPYQALIEFTFDISPNDVFITQVIGGGEFGDVCLGGLSKNSPAAAKWSVSNTTMGRGGGGGGYESEPYETVAIKTLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEKITEMLYGIASGMKYLTDMGYVHRVSFLRDLAARNVLLDMELRCKIADFGLSRGVRSEGSSVEPEYTTNGGKIPVRWTAPEAITHRKFTPSSDVWSFGVVIWEVCSFGERPYWDWTNQKVISEVMIGYRLPPPMDCPMGLYRIAQWCWKMERHERPTFTQLLATFHKYILQPTLIEHDPGELPRRVQSQSALNTYGSVNVGVVPTPPSSAAPMPSLDDFLRQIGLNHVYGQLVSNNIHSVSDLANTSHLDLLAYGLMSAECSTVRDGLNGRISGSPPGSSGTIHATTRGTRTTRPPREEGFFV
The following text describes a protein:
Function:
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
Sequence:
MGAGAGGGRNRVSPPEEGLQPGPPSPTEAPCAPRPPPPGPRSESPANPRPRPRRREQAALSARGAPAAGPGPAGAQTVPGWWPGRGGPSCQGDPGAGKAGGGGGTMSGRKRSFTFGAYGGVDKSFTPRRSVWRSDGQNQRFPQALDLPRVDLVPSHPASRYPKNTDLFEMIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMENGGGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEVLKDFSRSSSSASSFASVVEETEGVDADDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPGPSRSPHPDAGKSGDPACPEIKIQLEASEQHTPQLVSAAAGGGGGGREEAKADVASLEAALWDRLPRRC
The following text describes a protein:
Function:
ABC transporter that may affect phytic acid transport and compartmentalization. May function directly or indirectly in removing phytic acid from the cytosol or in vesicle trafficking. Required for phytic acid accumulation in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSWLLVTLYATYCKRKRAGASCGWPLVLVSWWVFSSLLDLISISVYLISLWNKTSLRNTIPAASIVEFTSFPISVFLCFTALFMCSSKTNLDLKQYLLLNDEDCAGRDNFSRAGFWSRLTFRWMNPVFEKGRAERLELSHIPGVPPSETAESSFSFLQESLRDQKTESASLLKAIIHAVWRPLAVNAVFAGLNTFSSYIGPFLITNFVEFISGEDSSHGHYYGYILACLFFFAKTVESLTQRHWYFGTRQIGVRVRAALMVAIYNKSLLMKHSGRSMGKIINFLDVDVERIGDFFWYIHGIWLLPVQVSLALLILYRNLGAAASFSALAVTILVMVSNTPLANLQERLHSKIMEAKDSRIKATAETLKCMRILKLHSWETAYLNKLLQLRDVERSWLRRYLYTCSAIAFLFWASPTLVLVIAFGVCILVNTPLTAGTVLSALATFRILQEPIYNLPELVTMITQTKVSIDRIQDFIKEEEQKQLRPSYKMKTSGIAVEIEPGEYNWDADSKSKKPTLKINKRIQIMRGEKIAVCGTVGSGKSSFLCSIMGEISRTNGRRISVFGSRAYVPQSAWIQTGTIQENVLFGKEMDRRWYQQVLEACALDRDIGNWADGDSTVAGERGINLSGGQKQRIQLARAIYSNADIYLLDDPFSAVDAHTGTHLFKECLTGLLSSKTIIYVTHQLEFIDAADLILVLRDGKVVQSGKYEDLLKDTDGDLVQQIAAHNQSLSQVSPSKEHGLLMSTRYRMKQKDLREVKYFENSGISELAERSCEEEREFGRVKWHVYHTFMTSAYKGAFVPVLLLCQILFQGFQMGSNYWVAWATQKEAQVSREQLIGIFVLLSAGSSMFILGRAVLLATIAIETAQQLFLEMITSILRAPMSFFDSTPSSRILNRSSTDQSTVDTDIPYRLAGLIFALVQLLCIIMLMTQVAWPVLILFIIVFAISIWYQNYYISAARELARMVGIRKAPILHHFSESLAGAATIRCFNQEERFSKRNLTLIDDYSRITFHNYATMEWLSVRINFLFNLVFFAMLTILVSMPRNDIDPSLAGLAATYGLNLNVLQAWVIWNLCNVENKMISVERILQFSVIPSEAPLVIEHFRAQQGWPTSGTIELDDLKVRYSPNLPMVLKGINCTFPGGKKIGVVGRTGSGKSTLIQALFRVVEPSSGRIVIDGIDISQIGLHDLRSRLSIIPQEPTLFQGTVRTNLDPLQQHPDSEIWEALYKCRLGEIVKQDQRLLDAPVAEDGENWSVGQRQLVCLARVLLKRRRILVLDEATASVDTATDNFIQKTIREETSNCTTITVAHRIPTVIDSDLVLVLDEGKILEFSSPQDLLKDESSAFSRLVMDFLGRSKNHHAELELE
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
Miscellaneous:
MISCELLANEOUS: As has been shown for E.coli (strain K12) and suggested for Salmonella typhimurium, the gamma subunit (approximately resides 1-430) might be generated by ribosomal frameshifting, leading to 2 protein products from 1 gene.
Sequence:
MSYQVLARKWRPKTFADVVGQEHIITALANGLKDNRLHHAYLFSGTRGVGKTSIARLFAKGLNCVHGVTATPCGECENCKAIEQGNFIDLIEIDAASRTKVEDTRELLDNVQYKPVVGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQKLPVTILSRCLQFHLKALDETQISQHLAHILTQENIPFEDPALVKLAKAAQGSIRDSLSLTDQAIAMGDRQVTNNVVSNMLGLLDDNYSVDILYALHQGNGELLMRTLQRVADAAGDWDKLLGECAEKLHQIALMQLLPQKSSDNNEHFSFLAKHISPENVQFFYQVIVSGRKDLSNAPNRRIGAEMTLLRALAFHPKFLTAVPKANTTITPPPSTPSAVENTGNYVDVPVLSQSIKSAYSQAKPNKTSIPNLASLSALDALEHLTQLENQERQEHKAESLAVVSETLHHIQELDEEKSHKKMTALPVREMTEPKPKHIEKPTLPSNAAQAPQKNSTEENSSDDNVEIAQDEQEILSADTYRWEWSNPELAKADTGVCPSDIKQAILKDITPELRLKIITQTQQQDQWADIVERSGLTGFSKELALNCFLQSKTDDEINLGLHSEKSHLRQDRSIKNLAEALSKLQGKDIRLTINLDDSNVTTPIEYRRNIYQALREKAQNELQKDSKLQILLNEFDAKLDVESIRPV
The following text describes a protein:
Function:
Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with KCNJ8.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSLSFCGNNISSYNIYHGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSQRASRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYWQLGWGMSDLRFCITGVMVILNGLLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHRKPIDLKAIGKLPIAMRAVTNYVCLKEAYEEQKKKAADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNEPKNNTTRFSETLSSKEFLENAHVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGEDSWRTGEGTLPFESCKKHTGVQSKPINRKQPGRYHLDNYEQARRLRPAETEDVAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVEENITFGSSFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWWYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSINDPGKADQTFYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLIALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTGPNLLQHKNGLFSTLVMTNK
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTLYYQIVFAMLVYEMALFLLLLAPFPTTWRRSMLKWVSNSKIVVKISYVMRIMFVFVVVLFVDSLNNVMKKHEHDEHGHSHADAHTESMVRAKMFYAQRNLYLTGSVVFLSLVLNRFFAMVFELMKNEEKSEELVEDAKTKLKDLEVVKKQAAQTADEYMRLTDRYVELEKKFENNSEFKKSK
The following text describes a protein:
Function:
Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MLATSAIAIFLIAWSAIFLIDYVLRVAQFEPYLHLCHRYGIEVSPFQLRFYVTSPPKENILLNEKADILDDEKKSGSDLFFEESRRSKCRNLLVRVWFACGVLASIICLLGMTAYMSHLLLKDVGQWVTTTRPKTQAYRGMEYRSMHEVLTSISPREVKTTTEQMQNPVIVESAEYDMIEDGQKSSSRGLVPIIPGFNLPWSHIPIFMTVLVVAAVFHELGHAWAAISNGVTVNGFGIFILAVYPGAFTDIEPVTLKRASAFRRLQIFGAGIWHNLLLALLALTVFHLTPIILSPILTQGNGVSVKAIDARSGLSNPKTGLVSGNIVKSIDECDVETVADWWRCIRASKNMHNGRCVDKEAVEAATAFNHRTEADEILCCDEFNVTTAHVCFEREEKVPKGVETQTRAPQLNALLGLEGHDDTPYGAAGTGQVEDKTITKYSCLHARHVVEQAVCNVSEPCKKEEADREKVCVYPALHNGTRLVKIELGNRAKPILFVGQLNEMLQMVSISPWTPRFSFVQISWLEHFELAVKYMFTLSLALGLFNAMPVYGLDGQFIVRTLLKSSGFSVKRRELIQYIVLTFGTAVLILNVLIGFIKLVIN
The following text describes a protein:
Function:
Cationic peptide that possesses multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor. It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MKILYLLFAFLFLAFLSEPGNAYKRCHKKGGHCFPKTVICLPPSSDFGKMDCRWKWKCCKKGSVNNAISI
The following text describes a protein:
Function:
Essential for Wnt/beta-catenin-mediated formation of the Spemann organizer and for induction of the organizer precursor, the Nieuwkoop center. Acts as a transcriptional activator, cooperating with TGFbeta signals to induce a program of organizer-specific gene expression and to generate an organizer with both head- and trunk-inducing activity. Activates the head organizer gene cer1 by acting synergistically with otx2 and mix-A/mix.1 through the 5'-TAATCT-3' element of the cer1 promoter. Also binds as a complex with lhx1/lim1 and mix-A/mix.1 to the 3x 5'-TAAT-3' element of the cer1 promoter. Required for subsequent dorsoventral axis formation in the embryo, dorsalizing ventral mesoderm and cooperating with t/bra to induce dorsal mesoderm. Also involved in neural induction, inducing the cement gland and neural tissue in overlying ectoderm. Later in development, has the second function of indirectly repressing ventral genes, probably by activating the expression of a transcriptional repressor (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTCEAEMEQIVSTALTLQEDYIKFTPRNPTMACHTEIIGVFHDIHPTVEKNKEAHRDKLVLQETLVELYSVLGIPQEPQVGKTMKFEEPEQHRGSARFDPLVNSLQLKRPLYEEERRECKRPLVQADEAVAAPSARSRRRTIYSKEQTHFLQNQFDLNPYPDFVNRCRIAKITAIPEPRIQVWFQNRRARHLPRAATSLSPQERKPPGSVGPRSSLCREAQHPEAWSEVLIPSDSQPHPN
The following text describes a protein:
Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Sequence:
MVISELALGLLTNLLYDSAKKIPGRLFDHSSKAYKNAIKELNKKYRQSGTQIDIFLRQKNVKTAIKEYLENPNSSDLLKSLNDDFLASFSEENFSREYAKSILNTFFEILDHEIEKDSELRENLKTHLAKQTYQISRETNQGVHNLSQGFQEMSQRVVEIHDKVINGNKMDQNFGKELGTDFQESITKYIYKIIAEDSEFGISEVYTELSAKEILPISLKFHDEKSDRTRDYEVLELVKKEERLIISGESGAGKTTTLKWLNFIYATNYLEGKNESIPLYVELNSYIKGSFYDYVRIKAQGRGISKDILEILLKGETILFIDGFDLLSPTDGFFPYEEISNFVSEYSNCKFIISSRPDFFESIRSDFKVSELEKLTYGKILTFIYKCVPDMETRGILNDKILGDKQLKSLFTNPMLLSLAIRVAMERKSNTEDLLPSSRPEMYKAFISGLFAHVKTKGKSLCSDQIQIRNALTDLYFRLQCWNKVSCEYDEALNFVAKNANDPRFKETTSQHILEDCFKLGLLNRKDTEVEYGFHQSFQEYFAAIKLKEYFENGFDISEAFSQPKWEEVVIFTSEMLDSADKFIDSIILKGNLFLASKCSNKASDEIKEKICSLLADKMDSKYKLEKINVIESLERIGIIGIGTIAKALRDEDKDIRWNAAEALGNIRSEAAVQLLLDALKDENEDVRSNAANALGSTGSKKAVKPLIDALEDENEDVRKEAAEALGYIESEGAVQSLIDALRDENEHVRSAAAHSLIVINDEIAEKSLIDILNNENEDLSVRWDAVKALKDIESEKAVKALVNALKDKELRNISSLMLGYLESETAVMLLIEALKDEDLDLQHNARQALGSICSSIIKSRDSFPYSAEFRNEYDTVVQLLVNALKNEDINVRRGVTGVFLQIQYEIAIAVQPLINALKDQDEEVRMNAALALSHTKSEAAVQSLIGALKDKSESVRGVAAHALGEIKSKTAVKPLIDALNDKSEFVRSDVVGALGEIKSEAAVQPLIDLLKDEDVNEDEYADEEEYIDEDIDGDIRVSAAIALGKIKSEAAVQPLIDLLKDENENVRWSAVVALGDIKSETAVQPLIDKLNDEDEHVRSEAIRALESFKSETAVRQLINALNNESKNVRKGTAAVLGVIESELSITPLINLLKDENEDVRLSAAYSLCNFESKHAMQLLINVMIDENEPESMRESLLKTFMLLSSYPQSRVGQSETMVQLFTNVMENENEGVGSEIIVKLLGNVMTDKDKHVRLSVVEVLGNIESETAMQLLINSLKDEAGDVQRKTAAILKEICTVKNKKQLEELLKSEHEFSVNTAFEILEKIEKEEESKTILFESGLDINEQG
The following text describes a protein:
Function:
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MARLIIVLVLILCIGVNIIQTKNALNEEDTHKIEDILPHYAGADHLDSFDQTLFLGGQTRAKIFRGLSDEKRKEVFSDVYKLVDTNGDGQISKDELTEWMFQALLTVDKEDAVNSMDPIDENKDKMVSWFEYHDHVYGYAMGEEMEENQAEYTKHIKRSKRSFDLADSDGDGFLTPNEFHMFHNPRLYKQMEKVVILDSLEDFDTNKDGGIEVVEFIGDFLLKDDEEELPEWVIEEKRLFETEHDLDGNGKLEGSEIFELESQEKSFREQAEREVDHLIVMADTDKDDLISLDEALQSEALFMGRDHATHFHQNPNIVVNKNIEL
The following text describes a protein:
Function:
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MASTPSKSSRSSKEAYSEVAIGPYTRLDHIGKGSFATVYRGVQTKSRTFVAIKSVNLGKLNRKLKDNLAMEIDILKYLLHPHIVALLDCLETNSHIHLIMEYCALGDLSQFIKRRDSLKDHSYTRHMISKYPNVSGGALNEVIVRHFLKQLASALRFLRDKNLIHRDIKPQNLLLCPAPKPAPTQSEAEPQIVPLKGSETSFTPAVGLETLPLLKLADFGFARSLPATSLAETLCGSPLYMAPEILRYEKYDAKADLWSVGTVLYEMVVGKPPFRATNHVELLRKIETARDRIKFPEENPASDDIKALVRGLLKFNPVVRMTFADFFENDIITGPIPGLAAEDVPIPDRPPSPEVIPTESAEPQSVSDTIYPRNNDAEPKEDRYPPPHRYVPHNDRPQTPTSSSPMRRTRSGDRPSSAKQIPPAAAPPRPEAVSHATAPGRQELIGRHSSEQQAPGTVPVYKNVDKLKEERELAAQEVAFERDYVVVEKRAVEVNAFADQLAYDPRFHGKQTGALPRRQTTPALPTTQASSQNSPRKAVQVVSGRSRADSAHNRHASYERRYGQSPTSATSAISKALNMASGRLFGVGFSPPLNIAKGGRSPPLAYNPFPAYPTGHAGLLTMGDGARAQASPDEDTRTVKELEECATRSDVVYGFAEVKYKQLIPLAPSSQSYNSPNAPGTNFEEGELTPDAAVTLSEEALVLYVKALSLLAKSMDIAGAWWMRKNRAEALGESSFSRLEPVSIRINKVVQWVRSRFNEVLEKAEFVRLKLLEAQRRLPTDHPSHPNNLSLESAGSGTSVDVMVSPGVTAEKLMYDRALEMSRAAAINELTSEDLPGCEIAYVTAIRMLEAVLETDEVQPSGKGTDKVTLDGVQGEEREVLLKLVSKIRMRLATLRQKLAVLAKRQTPPSSGKMIPSNLAHATPATPATGMATPR
The following text describes a protein:
Function:
Involved in the processing of pol II transcripts.
Subcellular Localization:
Nucleus.
Sequence:
MSGIAEFDGILDSLEHSKTGISGSKILKLTNLSMENVSENAQFVASVYKYAKRAPVTHKLGALYILDSIVRSFQDGAKKNNESFENPVDASFSGGWCKAAEITDSLVADAIQHAPSAHLPKILKLCDIWEKASTFPPEKLESLRSKLKDAMASTEPVSVDSAAAPSQSTNPEGNGGSVGSQAAAPTSRPVENDAASILEALAAFAQKAPVPSAAEESVSTPPQPAVAPSVSAVVPNLPVHPATAINAQSQSGNPLSNPLFQPSNVPQSIPSGPMGMKTGSVNDTQSQQITLMNVLASQNVPPAQIDSIMKAAFPNYNAPFQPAGVGSVPLPAPTSSQSLRLGSLHRSRSPSPRSGRPRRSPSPSHLSIPSTLPPADGVPKPTPDGFPRRFERDPTIPPDSIKVYSRTLFLGGITRSVREPVLRSMFERFGSVQSLILNHNYRHGFLKMFRRDAAEKAQVAMENVPFADTTIRTKWGVGFGPRECSDFSTGISVIPIRLLTDADRTWLVTAEYGGTGGLPITPGIALDEPDIEIGLGISSKAISKRGKDFAMRRDERFRGRKPYRGGPPIHHGERHFDSGNDWHGNPSTVPPPTNPYNPGYPYMDPNYSSGYVSQPPWQPQ
The following text describes a protein:
Function:
Peptide transporter. Mediates the transport of di- and tripeptides. High affinity transporter with low selectivity. No transport of amino acids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEEKDVYTQDGTVDIHKNPANKEKTGNWKACRFILGNECCERLAYYGMGTNLVNYLESRLNQGNATAANNVTNWSGTCYITPLIGAFIADAYLGRYWTIATFVFIYVSGMTLLTLSASVPGLKPGNCNADTCHPNSSQTAVFFVALYMIALGTGGIKPCVSSFGADQFDENDENEKIKKSSFFNWFYFSINVGALIAATVLVWIQMNVGWGWGFGVPTVAMVIAVCFFFFGSRFYRLQRPGGSPLTRIFQVIVAAFRKISVKVPEDKSLLFETADDESNIKGSRKLVHTDNLKFFDKAAVESQSDSIKDGEVNPWRLCSVTQVEELKSIITLLPVWATGIVFATVYSQMSTMFVLQGNTMDQHMGKNFEIPSASLSLFDTVSVLFWTPVYDQFIIPLARKFTRNERGFTQLQRMGIGLVVSIFAMITAGVLEVVRLDYVKTHNAYDQKQIHMSIFWQIPQYLLIGCAEVFTFIGQLEFFYDQAPDAMRSLCSALSLTTVALGNYLSTVLVTVVMKITKKNGKPGWIPDNLNRGHLDYFFYLLATLSFLNFLVYLWISKRYKYKKAVGRAH
The following text describes a protein:
Function:
Involved in the formation of 2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase.
Sequence:
MNAIANLAATPGADLGECLADLAVDALIDEAELSPKPALVDRRGNGAHADLHLGLMQASALSLWPCFKEMADAAQRHGRIDARLRGVLGQLGRDGEAAMLRTTEGVNTHRGAIWALGLLVAAAALEPRRTQAGEVAARAGRIALLDDPAAAIGDSHGERVRRRYGVGGAREEARLCFPRAVRHGLPQLWRSREGGAGEQNARLDALLAIMSVLDDTCVLHRAGRVGLAAMQDGARAVLAAGGSASLAGRRRLCELDRRLLALNASPGGAADLLAACLFLDRLPAVSGGWAGSL
The following text describes a protein:
Function:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Subcellular Localization:
Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
Sequence:
MSDLPSPPPFLVTSVYFTDSSRPLYLSPCAPSGHESSSKESSKSDDEDADKELIRLMATLGLPTTFGTSLEVKPVKNRRKSKAATSRVVGTHYDSQASQAEDPRETVDVGHQIFKSGPQFNLKTHVKTAAEDSSSCNVDDLHLSEFNDISNVDNQHRRTFSKSFWEPCWDAEYQRYYYCNTHTWETTWEVPEGVEDYNANVLVESNENIDDTVVLVDQVHPYESNSLSVLGETPNSLRKGALSKQQEYVGSCANDTNDTSVCFTSQGRDLDQNLEGNSQGIERRLGASGAPLSTGVVVPSKASSYSELEPVDSPEGKVTIVEQSSVARTIVSEERMLDQDFERKCISTQDIGFMESTKVDLSDPIEIRTKISLSQRTHIRFADSDDDDENREVALFSSMENTESKDALNDVNNGIFPVDYPQLDFEAKNETVYESVDGENMIKTFEKRKRRRNTTRMLEKMPTEVWSGLAENLNSDSLEEMSERTAKYWYQRYRLFSRYDEGIKMDEEGWFSVTPECIAQHQASRMFSGGLIVDAFTGVGGNAIQFALRGDHVIAIDIDPLKIEYARHNAAIYGVVDHIEFIVGDFFKIAPNLKADSIFLSPPWGGPSYSDVEKFDLHTMIQPLDGFKLFQVAQAVAPNMALFLPRNVDLDQLAELSWLASPPLPCEVERNFIHEKLKAITAYYGDVACTEVSASQVAASHEATV
The following text describes a protein:
Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Subcellular Localization:
Secreted. Cell membrane.
Sequence:
MEFWLSWVLLVAILKDVQCEVQLVESGGGLVQPGGSLRLSCSASGFTFSSYAMHWVRQAPGKGLEYVSAISSNGGSTYYADSVKGRFTISRDNSKNTLYLQMSSLRAEDTAVYYCVK
The following text describes a protein:
Function:
Acts as a beta-cystathionase and as a repressor of the maltose regulon.
Sequence:
MFDFSKVVDRHGTWCTQWDYVADRFGTADLLPFTISDMDFATAPCIIEALNQRLMHGVFGYSRWKNDEFLAAIAHWFSTQHYTAIDSQTVVYGPSVIYMVSELIRQWSETGEGVVIHTPAYDAFYKAIEGNQRTVMPVALEKQADGWFCDMGKLEAVLAKPECKIMLLCSPQNPTGKVWTCDELEIMADLCERHGVRVISDEIHMDMVWGEQPHIPWSNVARGDWALLTSGSKSFNIPALTGAYGIIENSSSRDAYLSALKGRDGLSSPSVLALTAHIAAYQQGAPWLDALRIYLKDNLTYIADKMNAAFPELNWQIPQSTYLAWLDLRPLNIDDNALQKALIEQEKVAIMPGYTYGEEGRGFVRLNAGCPRSKLEKGVAGLINAIRAVR