lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional activator that binds double-stranded DNA and the single-stranded RNA polymers poly(rA), poly(rU) and poly(rG), but not poly(rC). Mediates optimal plant architecture through brassinosteroid (BR) signaling. May act as a negative regulator in sterol homeostasis. Acts as a negative regulator of BR signaling. Binds to the specific DNA sequence 5'-CTCGC-3' of BZR1 promoter and negatively regulates BZR1. Acts as an antagonistic transcription factor of BZR1 to attenuate the BR signaling pathway and regulate leaf bending. Represses the expression of ILI1, and activates that of IBH1 to balance the regulation activity of BZR1.
Miscellaneous:
MISCELLANEOUS: Plants silencing LIC are short, have increased leaf and tiller angles, and display both reduced number of rachises and seeds. Plants over-expressing LIC show erect leaves.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Brassinosteroid promotes nuclear localization. Phosphorylation represses nuclear localization.
Sequence:
MSRRQEICRNFQRGSCKYGAQCRYLHASPHQQQQQQQAKPNPFGFGTGSRQQQQPSFGSQFQQQQQQQQKPNPFGFGVQGANAQSRNAPGPAKPFQNKWVRDPSAPTKQTEAVQPPQAQAAHTSCEDPQSCRQQISEDFKNEAPIWKLTCYAHLRNGPCNIKGDISFEELRAKAYEEGKQGHSLQSIVEGERNLQNAKLMEFTNLLNSARPSQTPSFPTMSSFPEVKNNSSFGASQTNGPPVFSSFSQIGAATNIGPGPGTTAPGMPASSPFGHPSSAPLAAPTFGSSQMKFGVSSVFGNQGSGQPFGSFQAPRFPSSKSPASSVQHRDIDRQSQELLNGMVTPPSVMFEESVGNNKNENQDDSIWLKEKWAIGEIPLDEPPQRHVSHVF
The following text describes a protein:
Function:
Involved in the biosynthesis of ent-kaurene diterpenoids natural products such as oridonin, miltiradiene, eriocalyxin B and nezukol, known to exhibit antitumor, anti-inflammatory and antibacterial activities. Catalyzes the conversion of (2E,6E,10E)-geranylgeranyl diphosphate (GGPP) to (+)-copalyl diphosphate ((+)-CPP).
Miscellaneous:
MISCELLANEOUS: Abietane diterpenoids (e.g. miltiradiene, abietatriene and ferruginol) accumulate specifically in the periderm of roots. The ent-kaurene diterpenoid oridonin, main constituent of Isodon rubescens, accumulates in leaves.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MGIRLLKMHGYDVDPNALKHFKQEDGKFSCYGGQMIESASPIYNLYRASQLRFPGEEILEEATKFAYNFLQEKIANNQIQEKWVISEHLIDEIKLGLKMPWYATLPRVEAAYYLQYYAGTGDVWIGKTFYRMPEISNDTYKELAVLDFNRCQAQHQFEWIYMQEWYQSSSVKAFGISKKELLLAYFLAAATIFEPERTQERIMWAKTQIVSRMIKSFLSKENTLSLEQKTTLLIDFGHDINGLNKINSVEKGNGLAGTLLTTFQQLLEEFDRYTTHQLKNAWSQWFVKLQQGEGDGGADAELLANTLNICAGHIAFNEDILSHRDYTTLSSLTTKICQRLTQIQDKKILEIKDGSIKDKELEEEMQALVKLVLEENGGGIDRNIKQTFLSVFKTFYYCAYHHAETTDAHIFKVLFEPVV
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage (By similarity).
Sequence:
MSSTEDDRQVRISKIAGRYLVFDIDDVAYIRRQHGICAVFTGTMPQNPTQNVFLGLPLELYAEDAKMLLDRKVAYIADDPLEHLTQLKSMDDETRKSYLQSIKTQRRTAQLVFNEAKAQSMAKHKDKRKPKQPQPSVVVPTELPLSASSADGVAAAVDQEEEGGAEFLLESSSSKPLKTDASTPPQKPLVKEKLPAITPTTSNAMISNGTSNPDVENHTALPLYSYLNERGYFITPGLRFGGDFSVYPGDPFRYHAHYMANSYGWDEKIPMLDLVTSGRLGTAVKKSFLMGGQKPATEDSEAGELRAFCIEWAGM
The following text describes a protein:
Function:
Adapter required for innate immune defense against viruses. Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion. Peroxisome.
Domain:
Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with RIGI and IFIH1/MDA5 (By similarity); The transmembrane domain and residues 288-424 are essential for its interaction with DHX58/LGP2; The pLxIS motif constitutes an IRF3-binding motif: following phosphorylation by TBK1, the phosphorylated pLxIS motif of MAVS recruits IRF3. IRF3 is then phosphorylated and activated by TBK1 to induce type-I interferons and other cytokines.
Sequence:
MTFAEEKTYKYIRYNHSKFCCVDVLEILPYLSCLTTSDQDRLRASYKQLGNQGTLWELFNTLQRRPGWVEVFIRALRICELPGLAEQVTRVYQSYLPPGASLHSLDPLQSPRIPTTVSEPSAFAAGHTIPDSGFQDKPGYPKPVQDTQPPKSPVENSEEPPQANFGAIPRMSGDSLISSPNPPALSPQPSREHPEQEPELGGPSTANVDSVPIATYGPVSPTVSFQPLPRIAPRTNLSPGVTVSALSAKTTLSSSSTGSAFAKGAGDQAKAATCVSTKEGVPTNSVTTSSVPSIKPVPVNTMSSKLPISTKSTAATPSTVPTNIAPSKLPINSVYTGIVPSKVTASVAKASASTMPPERNNKQAKETLEAPATVVTTGSSLTRPDISSRSLHSGPELSKPGVLVSQVDNEPFSACSMDLAISPSTSLGSEPNHGPEENEYSSFRIQVDKSPSVDLLGSPEPLATQQSPEEEEPCASSVSWAKWLGATSALLAAFLAVMLYRSRHLAQ
The following text describes a protein:
Function:
Ligand-gated cation channel that allows the movement of sodium and potassium monoatomic cations across cell membranes when activated by zinc (Zn2+), copper (Cu2+), and changes in pH. Could also transport cesium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMALWPLLHFTFLGFSITWPLVHGQGFQETAAVWPSLFNVSLPQKAQESIQIPNNGSAPLLVDVQVFVSNVFNVDILQYTMSSMLLLKLSWLDTRLAWNTSAHPRHAVTLPWDSLWTPRLTILEALWVDWRDQSPQVRVDQDGHVKLNLALTTETNCNFELLHFPRDHSNCSLSFYALSNTAMELQFQTHAVNEIVSVKREYVVYDLKAQVPPQQLVPCFRVKMSLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLGYLVFHSSLVQALPSSSSCNPLLIYYFTILLLLLFLSTMETVLLARSSLGAKSSPSPAPRGEQQEHGNPGPHPEESPRGVKGSQRSWPETADRIFFLVYVVGVLCSQFIFAGIWMWAACKSGPAPGEAAPHGRRPRP
The following text describes a protein:
Function:
Cysteine dioxygenase involved in sulfite formation from cysteine. Plays an important role in filamentous growth and virulence.
Sequence:
MLLNQYTFSAERCTTPTSISHPPLACPTSPPPTNSLNRYQHKPVTLAPTVDHGCEINGTTIDCIPKDSKFYQLIMDLKQLLAGKGLSNEDIDVEKVKQLMADYDSNEIDWQHLALHDPSRNYSRNGIINLNGNANLLILVWSPGKSSAIHDHADAHCCVKMLAGELIEHLYDFPDHEGEELQCRQETSMKRNDVGYINDSIGLHKMSNPLQNRVSVSLHLYTPPYASMYGCSMYEASSGRKHHVDMSKYYSWQGQLVNEKESSTC
The following text describes a protein:
Function:
Aspartic protease. Required for the cleavage and activation of transcription factors such as isoform a of the transcription factor skn-1, which in turn regulates the expression of proteasomal subunits such as rpt-3. Plays a key role in the degradation of the potassium channel slo-1, perhaps acting directly, in cleaving slo-1 upstream of the ER-associated degradation pathway (ERAD), and also indirectly, via activation of the transcription factor skn-1, which mediates proteasomal homeostasis.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Mainly localizes to the nucleus during proteasomal disruption.
Sequence:
MSFQVSVAVNDGPFQKKSVTPNTTIGDLNNDAILIWKDTAIVYDISDESKNFGPTVTLEQLGVTQISMVYIYTTAFPCPSGDLRSIVPAQVRLISQFASAASSIFNGQSSSSAQSAQRTRRVEQDDEGEKSMFSRKLLDSPATFKALSENMFFRLKNEPHKLGYGLPELVERFLAKKDMTYKEFEQMFRSYVEEEVHKEEIIKNNPNSAEAKMFLEAKRNKELIDEQYLHSMTHHPEDMIAVTMLYINLTINGVPVKAFIDSGAQKSIMSMACAERCGLNGLIDRRFQSMARGVGGTEKIEGKIHLCDVKVEDAHFSCPFEVMARREMDLLIGLNVLRKHGCCINLKTSRLEFGNGTTTPFLQSNEIDSHLKEIMALPEEEMQFEDGST
The following text describes a protein:
Function:
Mediates the uptake of pyruvate into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MASKVSGMFWTWVHSSTGPKTTHFWAPVCNWFFPIQALYDWNRDPAKISKEMQCVLVCYSSLFMRWALRISPQSYILFCMHLFNATLQGRLLIRRLTWESTQQKAIEDKPTN
The following text describes a protein:
Function:
Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP.
Subcellular Localization:
Mitosome.
Sequence:
MSIQENLNNLIKPHGGKLIKTLKYGAERDECIKEAKSLPKIDISSREFGDLVMMGIGGFSPLNGFMKKEDWFSVCKNFTLADGTFWPIPITMSVSEEEAKKLKRGQKVALKYNKDINDISGTIEIDQVYEMTKKDKEMECKDIFTTTDSDHPGVKKVMEQKPFNVAGKVTTLSEGEFPIKYKGIYMTPEESRLNFAKKGWKTIAALQLRNPMHRSHEFLAKIAVEVCDGVFIHSLVGNLKPGDIPAEVRVKCIDALVDKYFVKKNVLQGGYPLDMRYGGPREALLHATFRQNYGCTHMIIGRDHAGVGDYYGPFDAQKIFDKIPYNADPKKRLLTQPMKIDWTFYCHKCDGMASLRTCPHTKKDRVIVSGTMVRKMLSEGKTLPDHFGRAESLKILADYYQHLDKSKKVTIKLQKFATGDAMK
The following text describes a protein:
Function:
Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the Tse5/RhsP1 toxin to target cells where it exerts its toxicity.
Subcellular Localization:
Secreted.
Sequence:
MAIGQPFATALGCTIIWRAAGALFGPPAAGDYQGRFPMLFSQHTRLVHVDSPLGPEVLQLQRLEGREELGRLFSHELELVSSNPALPLDALLGKPMSLALELPGGSRRYFHGIVARCSQGAGAGQFASYQVTLRPWLWLLTRTSDCRIFQNQKVPDIIKQVFRDLGFSDFEDALSRSYREWEYCVQYRETSFDFVSRLMEQEGIYYWFRHEKKRHILVLSDAYGAHHSPAGYTSVPYYPPSLGHRERDHFFDWHMAREVQPGSLSLNDYDFQRPGTRLEVRSNVGRAHAAADYPLYDYPGEYVQSQDGEHYARTRIEAIQTQYERVRLRGCARGIGAGHLFHLSNYPRLDQNREYLVVGAEYRVVQELYETGNGGGGAQFESELDCIDAGQAFRPLPSTPVPVVRGPQTAVVVGPKGEEIWTDQYGRVKVHFHWDRHDQSNENSSCWMRVSQAWAGKNWGSIQIPRIGQEVIVSFLEGDPDRPIITGRVYNAEQTVPYELPANATQSGTKSRSSKGGTPANFNEIRMEDKKGAEQLFIHAERNQDIEVENDESHWVGHDRTKTIDHDETVHVKHDRTETVDNNETITVHANRSKTVDRNETVRIGMNKTETILMASLQNVGMGRMENVGLGYSLNVGMMMNTVVGLNQSTQVMKKKTLSVGDSYEVSVGGSDDGSKITLDGQSITLGSQRIELTADREILLRCGQSTIRLTPGEIEILSPNVDINC
The following text describes a protein:
Function:
Polynucleotide 5'-kinase involved in rRNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MNAKMTIWKSTLCNLERDFPSTDRVPFFAWATGKASINDFVLPSVSCEKGNFLKISAPQRMDLPVILKTSIDSSTAYKHSRLKFRLKEVAPKCYSDIMQMIGEKEPVVLVFNKVLDTAEATVSGVITNFLIHSSIQKQIILPPHFHISRDDFRIYPQDDEARLNTHLNRLNSLKADGVKTSILPIGHKGAGKSNLMRNLVNRCLSNGYEHVYVLDCDIGQSEFTPNGCISLTKVTSPLLDKPYGHQKKTFDNSYFYGDITVNDNNIDHYMDIFERLFNKFKLISEPGSVCIVNSMGWIVDEGAEILDGIIRVIEPDLCVEIFRDQTEARYSFKEFEKCKVVEIFANNSVGVIGLPNQKKLPAPLHRELTITGYFSSLLPRPTIASFASVPPYRLNFRNITICLPMDLLVEDCHIFSSINTQLIALCVKNPDLKTRKLNGKQDMPSLSVIDSTSPALQCIGFGIIRGVNVEERSVYVVTPVNLLKLQEPPLLVRGMRIQTPSQFFTADPYNRCPYVLNLPDKSSHASANLDGLYEPSINTTQFKRSRRF
The following text describes a protein:
Function:
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Subcellular Localization:
Chromosome.
Sequence:
MKVVHPYHPYTPRGQEHRGICSTEKSGRGRKALNLGATPKNSVPQNSAVSPAPASLPHPSPNTTTPATPNVQQVPGQQQQQQQQQQQQQLVTVSGAQQPGTAAPPTAASTASAAHNNSNGVLLATGIPSQHQHQQQQHQQQAQLQHHLARHPPIPPGAPPPGGGGPGSLQQQQQQQQQQHHSIIVKSEPSVEVMKDQPQQPMAPMAFYPTWQADPSQGWQNQFIQQIPQNTPAITPLNSLEFQPQGYAAYQPNGYVQTAGIGFDPNYGRTYAAPPAVQRYDFQANQIAPINQVSLQSVSFAPTVTYAGQVSTGPATIVSGHAGTTTNPHDQFNLQLGGSKQQQQSTAAASAASGNDMPGYPRVNSVPPRSLNCNGYSGQQDYGGLQTSTTTTTATTAASANGSSSSSSSSSVAPTTGTSSASPSAATVATAPNTGNGGGSSSNNSSTNNNNNGSTGSSSSMHPPQGVPQSPNRQPPRPNSNNQQQQLYAQQSPNPYNGSAGGSGGSLQQSPSHNGNNTPAGGYGSGQSGMHTPSPMQQGTAATDNQHQQSPSHMQGDWGWTQQQQQQQQQSQSGTDLFNQSDRVNLNSRLKTMIMSKGDQKDALLAGGQSSHLVGSHLGLQQQQQQQQTGTQSTGHFLSYSHHLRDSLTPTHHLGGGPGSAQSASSAGPGLMPGGSGSSNSSSSTAANDGTTIGDGGGSGGGGGGGGGLINSIGNMVDQSWKHQQGAGSNSNGSGTNNSSSTSVAAAAGMKSPSLTDHHQQQQQHHQHHHHHHHSHHQLQQQQQHDHLLAGDLHHGAKHSVFEQKQQLIDKNNTDPGGGGGIGSPTGVGSELKGKMGKSGGSSSSSSAAGSPSAGSPSSKAKGKGGDKHGKSKHGGHHHQQQQQHQQHHLDHLGLVDGKSSSSYSSSNFMMHHDQQLQLQQQQQQHQGYSNMNQTYPGSGSTTPNGSHQTSSGSLLGYSPAGGASSMMVDSKLVDDKSPLNRFRHDSLSSGFNPHLQAGGTGTSGAFHHPGGSSAGQSAGSGYNLMSVKKEPGLMDDGQTALPKFDGGYEKNYQNFIRYGDYCDNTQSPGAQASLQAGGGAGGASVKSASTDYNSYYSPYGSYSSYSTQSYPNYHNQQSSAAAASGFGSGTGSNSNSNSSLPPAQTPEGNALLSLPAISTPVTHQTNFEQQIPAHTYPIPKNNSLLPASDQGVSIKLEADDSAYGGSMGNSSATLGSEPGSDPGIGNQSSGSGTGALAEIDVGSQPVATTVGGTTTTTTTTTTTNTTTGTKSKSKKGEKKDKAAKDNSHGAGGDGADGKAEGGATTGGSTTSKSKSKKESKSVKKEPIDPAQKADDDKLEKSHKPEAPDCDCFSSGTDKAPSEPGSYYTHLGCAATLEDLRRETELRVGLTGKQLRIEKVVYTGKEGKSSQGCPIAKWVIRRVDPEEKLLFVVKRRQGHRCKASFIVICIVVWDGIPTHEADSVYRMLAVKLNKFGLPTVRRCATNENRTCACQGLDPELCGVSYSFGCSWSMYYNGCKYARSKTVRKFRLSVKNEEAEIEERMNVLATMLSPLYVTVAPQAFQNQVQYEREAPDCRLGLKPGKPFSGVTCCLDFCAHTHRDLHNMQDGCTVQVTLLKPLPPGVKPDDEQLHVLPLYTMDTTDEFDSEEGQKKKHETGAVQVLEKFQTEVRVRSTPLQPCRRHGKKRGNGKDEKLGKDGSDGAAPDTPPPPPPPTKKESKSKSKKSSAASTASSGASTANSVASPGPGGSGSTGAGGGSGGSGSGSPRAHTPGSQKSTGSGKGGSGSNGGSSNAALDLVTGVLTEKHSSPLHGQGAGGAGGALVAAGGGNGGTGGSSAFTAPNTINSPNSLANNGANNTNSTLIDMASMIDNFTDAQLQSNQISSTVLDSPYSYDYNTGQYIDNRQYYNNWPTDYYGNRGDPSKLAGLGRNEEIPDTTTRPGSNSSNSAFSPSIPDPTKTPTPIHMDDYGSTKLGQGQVHHHHHQLQQQQQQQQQQHQQQHQQHQQQHQQQQQHQQQQSQQQTQNTYHTLQQPEQGFVKPKPPDYNPAAGYGYHHPNTPMGYGYHHHHHPPYHHTPYDPYQNYNYGYPPQSYHHHHHTTYHNMYPAAAAAAAAAQTQLPGTGPAPPPPPTAVIPAPPPPSNWNLYPPHLGTAPSTAQLHVAAAAAGALGKQSELGGAVGAGMMSQSAVVPQAPAAPPSAPLPPKETLGEVTETNENLDCFEDPQMGGVAIALPHGSVIIECAKLEMHSTTAVKKPNRLNPTRMTLIFYQHRNLNRPKHGIAEWAEKMRLKKLGIPTNDPLDDKDMLLEDDIKAEPLDELHHMRHIGDEHDMMDVEYPGV
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediator between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction; Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MEYSNLQQQAASLKKNLFDQGYLDEQFCQIEDLQDEASPNFTEEVVSLFFKNSTRLMTNIEQAMDRNPRDFCRWDVNMQQLKGTCSSIGACRMKNECTSFRNRCGDENVEGCMRSFQNLKREHGVLRQKLESYFQLLRQAGPAVTATRPRGM
The following text describes a protein:
Function:
Putative FAD-dependent oxidoreductase.
Sequence:
MGSSSSQPKNDFNVIIVGGGYAGITLAGKLDDYCNVTLIDPKDCFHHSIGALRCVVEPGFIKKTLIPYKGFLKYGTFIQAKCVSVHVSLRTVTLSNGQELSYDYLVFACGSSVPFPGKVPQGVTREDAHKLYEELALQVKNSEKIVIIGGGPVGVELAGEIANDYPSKKVTIVNAKEQLISNKMSEKFQKKINKGLKDLKVNLVLGEKIAMDELDPWVQGPITITTDKGTSIEADLVFRCTGFKVNADAYRSKLSDKMDHNTGSLKVDAFLQVEEMRDVFAIGDCNNTPEIKLAYGATLQAETVAFNIKQLNESKRMKEYKLLNALMVVPMGRNRGAAQLPNGMVFGNMFAKGIKGKDMMTGKIWKQMNQKKPS
The following text describes a protein:
Function:
Plays a role in the regulation of phosphate uptake.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEVVTDRLRMALEAMAQKDDDAAWEVIDGDDEINQLYLDLEDDCIDLLALQQPVAGDLRLIASSFKIITDLERIGDLAANLAEYTLDADRDMFPEVDVQAIGDRTIEMVTDAMAAYASADVEACYAIAERDDDIDERCRSASQTVIRDLIETEIDAATDDAEIEALMQDVSRLLLTVRDLERVGDHAVNISARTVYMVDNDDELIY
The following text describes a protein:
Function:
Receptor for metastin (kisspeptin-52 or kp-52), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MATEATLAPNVTWWAPSNASGCPGCGVNASDDPGSAPRPLDAWLVPLFFATLMLLGLVGNSLVIYVICRHKHMQTVTNFYIANLAATDVTFLLCCVPFTALLYPLPAWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLALHRLSPGPRTYCSEAFPSRALERAFALYNLLALYLLPLLATCACYGAMLRHLGRAAVRPAPTDGALQGQLLAQRAGAVRTKVSRLVAAVVLLFAACWGPIQLFLVLQALGPSGAWHPRSYAAYAVKIWAHCMSYSNSALNPLLYAFLGSHFRQAFCRVCPCCRQRQRRPHTSAHSDRAATHTVPHSRAAHPVRIRSPEPGNPVVRSPCAQSERTASL
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Sequence:
MGKGNAKNSGGGDKKSKAKAGDAKDDSKGKMKGAQSVNVRHILCEKFSKKEEALEKIRNGAKFDEVAREYSEDKARQGGSLGWKSKGELELPFEEVAFSLEQSTTGNPKIGEAKTGYGYHIIMVEGRK
The following text describes a protein:
Function:
Chaperone required for the assembly of ubiquinol-cytochrome c reductase of the mitochondrial respiratory chain.
Miscellaneous:
MISCELLANEOUS: Present with 14200 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion membrane.
Sequence:
MMSVNRFTSGRLPVFLRKSPFYYSRAYLHQTCVFKQNKETAQDSPELLAKSSHLNSKPLDVSNKAPVKTAQNKIPLAHSKYESSKYELPKWKEALGELVIRAFHLDMDRVRAGPVAGSYYYKICKEQGLQYEDEPLSETAKYFYEDLKLPRTFSQWFQITVLHEWILFVRMRAMPFKYGRNYQQKLVDRTFSDIELRLFEEMKVNSGRIADQYLKDFNTQLRGAIFAYDEGFATDDGTLATAVWRNLFGGRKNIDMVHLESVVRYIYSQLYVLSRLSDREFATGKFKFVPPGVKVEKLTPKQEEELKAKTIAKYEALDKDPKTLPSERSRLSYTN
The following text describes a protein:
Function:
Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends.
Subcellular Localization:
Mitochondrion.
Sequence:
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADSCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAAKERSQMNSQSEDHALAPARNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSACGKTIESIQLSPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLLLNVVSQLAKQNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYDEDLVERCSYEVPTKWLCLHQKT
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MSTDLLYEYFYPPTDLFKNTFEDVPPSPESLDVGDSLGSSPSYDLGFQPSFDIDFCIWKEGSSSPPPESNHLPEIVNKASTSPRGMPSPLTDSRSCHVCSSPTANTLHFGGRSCKACAAFFRRSVSMSMTYECIGTGDDTNPCRTHYELRMICRHCRFIKCLDAGMRRELVQARKEETRVAKRRSKGLVVSKKEDDDVESSYDEYVNTYTNVQDSSPKMESGINEMTIPESYLSPDPSSSQPLDMTVTPPPLHRSTPSILLTPATGDRMHCQRVLSNSPPFDIHQASTSHAGFIQHVQFYPVVEVENKIFELVDHYVRTEASLNDRRKIMYTDTQIRDVFDTTCECPYENHQLKPFNYKSFCGFVKHDFVMILDYVNQFPEFQALHKNDKNVVYRMACAVDSMLASAYYSYKVGIEKERLILFNGDYINMNPIPISGDEPGAGTEFQTPQEHEKYKTLMPLKLKQYFDLAIPFARLEVSFEEYVLLKALIIWQISNYRLLEEGRAICARQRDTIVQALHKVVEERGDEDPAIRVGQLLLSMSYITEQVQAMTNSYLVMTFFDVVSCDSIMYDLLSFRDD
The following text describes a protein:
Function:
Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MLLHMTGMLGKLLFILQSSVTSSTSSSKTPTPTSQQSWSLLPLCFHHTSCLKLLFSPSGAGRCRLSKVGAGRRPPPARVRVAVRLRPFVDGTAGENDTPCVRGLDSCSLEIANWRNHQETLKYQFDAFYGERSSQQDIYAGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLTREEGAEGRPWALSVTMSYLEIYQEKVLDLLDPASGDLVIREDCRGNILIPGLTQKPITSFADFERHFLPASQNRTVGATRLNQRSSRSHAVLLVKVDQRERLAPFRQREGKLYLIDLAGSEDNRRTGNKGLRLKESGAINTSLFVLGKVVDALNQGLPRVPYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYLDTVSALNFAARSKEVINRPFTNESLQLHVLASVKLSQKELLGPSEAKRARGPEEEEIGSPEPPAAPASASQKLSPLQKLSSMDPAMLERLLSLDRLLGSQGSQGTPLLSTPRRERMVLMKTVEEKNLEIERLKMKQKELEAKVLAQEATDPKEKENCSPIMLRPLGRRTVTVAKPLKKAVVMPLQLIQEQAASPNAEIHILKRKGGKRKLESLDASESEEKANDCWELQISPELLTQGRQKILDLLNKGSARDLRSLQRIGQKKAQLIVGWRELHGPFSQVEDLGRVEGMSGKHMESFLKANILGLAAGLRCHPS
The following text describes a protein:
Function:
Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MRILCRIFASAQIHCKIPGIVQPSHFHSASACSGLTVKSVMEHKLYRPPPEVRGMTSLDKDAFTQTITVPALRVPTVVINKVMKSLKKATIQRPGVSRVVQDKEGNSDFRLILLDPNRMASSSCFSDAEAEALRSFSVSDELHNFELKLTYDNLKTEEVLEAVLPEGQDVTSGFSRVGHIAHMNLRDHQLLYKNLIGQVIMDKTPGITCVVNKTNTIDSTYRNFKMEVLAGEENMVAKVKENGVTYEFDFSRVYWNPRLSTEHERVVQLVKRGDTMFDVFAGVGPFTIPAARRGANIFANDLNPESYRWLQHNSRLNKVESRVRTFNLDGREFIRGPLKQELPALVKGGAGVHVVMNLPALALEFLDAFRGLLKNEPPCDLNLPTVYCYGFSKDEDPGADMVKRASSSLGFPLENKSTVHFVRNVAPNKDMMCIRFTLPKEVLFCKNDELQEPSEEPASKKQKCEESNHSK
The following text describes a protein:
Function:
Acts as a component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC63 may affect SEC1-polypeptide interactions by increasing the affinity of targeting pathways for SEC61 and/or by modifying SEC61 to allow more efficient polypeptide interaction. May also be involved in SRP-dependent cotranslational translocation. Is essential for cell growth and for germination.
Miscellaneous:
MISCELLANEOUS: Present with 17700 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein.
Sequence:
MPTNYEYDEASETWPSFILTGLLMVVGPMTLLQIYQIFFGANAEDGNSGKSKEFNEEVFKNLNEEYTSDEIKQFRRKFDKNSNKKSKIWSRRNIIIIVGWILVAILLQRINSNDAIKDAATKLFDPYEILGISTSASDRDIKSAYRKLSVKFHPDKLAKGLTPDEKSVMEETYVQITKAYESLTDELVRQNYLKYGHPDGPQSTSHGIALPRFLVDGSASPLLVVCYVALLGLILPYFVSRWWARTQSYTKKGIHNVTASNFVSNLVNYKPSEIVTTDLILHWLSFAHEFKQFFPDLQPTDFEKLLQDHINRRDSGKLNNAKFRIVAKCHSLLHGLLDIACGFRNLDIALGAINTFKCIVQAVPLTPNCQILQLPNVDKEHFITKTGDIHTLGKLFTLEDAKIGEVLGIKDQAKLNETLRVASHIPNLKIIKADFLVPGENQVTPSSTPYISLKVLVRSAKQPLIPTSLIPEENLTEPQDFESQRDPFAMMSKQPLVPYSFAPFFPTKRRGSWCCLVSSQKDGKILQTPIIIEKLSYKNLNDDKDFFDKRIKMDLTKHEKFDINDWEIGTIKIPLGQPAPETVGDFFFRVIVKSTDYFTTDLDITMNMKVRDSPAVEQVEVYSEEDDEYSTDDDETESDDESDASDYTDIDTDTEAEDDESPE
The following text describes a protein:
Function:
Flavoprotein monooxygenase required for N-hydroxylation of the two acylated lysine residues during mycobactin assembly, thus producing the hydroxamate groups necessary for iron sequestration. Is also able, but less efficiently, to hydroxylate L-lysine (non acylated) in vitro. Shows 5-fold preference for using acetylated lysine over lysine.
Sequence:
MNPTLAVLGAGAKAVAVAAKASVLRDMGVDVPDVIAVERIGVGANWQASGGWTDGAHRLGTSPEKDVGFPYRSALVPRRNAELDERMTRYSWQSYLIATASFAEWIDRGRPAPTHRRWSQYLAWVADHIGLKVIHGEVERLAVTGDRWALCTHETTVQADALMITGPGQAEKSLLPGNPRVLSIAQFWDRAAGHDRINAERVAVIGGGETAASMLNELFRHRVSTITVISPQVTLFTRGEGFFENSLFSDPTDWAALTFDERRDALARTDRGVFSATVQEALLADDRIHHLRGRVAHAVGRQGQIRLTLSTNRGSENFETVHGFDLVIDGSGADPLWFTSLFSQHTLDLLELGLGGPLTADRLQEAIGYDLAVTDVTPKLFLPTLSGLTQGPGFPNLSCLGLLSDRVLGAGIFTPTKHNDTRRSGEHQSFR