lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays an important role in regulating the size of autophagosomes during the formation process.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MRPLMLGLVPLFFLVLASLLCGAASSQQDFYQLLGIARDASTRELRRAFKKLALEKHPDKNPHNPQAHVEFVAINQAFEVLKDPETRRIYDRFGEQGLKDRQEQEQQQQRYESYQFYQEEFGLYDNDPQVDTLTVHDFDHAIHSAKVVFVNFYSPVIAMISPPHGASWPQLYMGLPLWLLSTARKIGIFASTGGFKPCLLFYFSKMARRVVCTRDDNPFSGHPTPYRGLRDLEALQSAVIAALPSVSPLPALAVSARGLDWSHLKDTPTANAPYLVIVICAPREPCLSEDDLVLLQAMVHDFAALQVLSCLRPLPIAEPSLADFGTDRLTLFDAPSPKTATQRLGIAVARALHRLGPVTRVACDNVCQRLHHVHELPALRVYTPVGHETYFGAPDSESIVAWTKQARAAPVEQLHASDFPGRVMQGTQARLVDFYAHWCQPCQQLAPFFREAAATSSFADVRFATVNCAVEVQLCRDLNVHSYPTLVYYPGGNAEPILFHGDLFSTRGLLTFLQQTLDPSTVTLTTATFHKQVFANDDQIWVIDFMSSRCGPCLHFKPEFERAAFQLRGLVKFATIDCISEAHLCMQERIHQYPTVRICQADQWGKKRCSIYQGFLHADHLLATVRRHFPSQTKDITGPRLRKEIATGAKVWLVAFATPWCGPCQQFKPALNELAYRASRNATDLQVGAIDCQRFERACRLQQVPHYPFLILYRGQGVQPLRMDAASPEEIWSRLEEAVPEVFKAPNSFHDEL
The following text describes a protein:
Function:
Required for ciliogenesis, particularly in neuronal and retinal progenitor cells (By similarity). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (By similarity). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a role in cardiac development. Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity).
Subcellular Localization:
Cytoplasm. Cell projection, cilium. Nucleus. Cytoplasm, cytoskeleton, cilium basal body. Note=Also found at the ciliary tip.
Sequence:
MNRYTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANIVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFIWPQCIPNNLKTLIPNASSEAIQLLRDLLQWDPKKRPTASQALRYPYFQIGHPLGISTQDSGKPQKDVQDKTGPPPYVKPAPPAQAPTKAHTLISSRPNQASQPHQHFVYPYKGEASRTEQLSHVQEGQPNPPFFPSLHNKNLPPKILAGLEQKSGDMKPKSRRRWGLISRSTKGSDDWADLADLDFSSSLTRIDVKNKKRQSDDPLCRFESVLDLKPSEPVGTGTSVSTQASSQRRDTPTLQSTAKQHYLKHSRYLPGINIRNGVLPNPGKDFLPSSSWSSSGLSGKSSGTVSVVSKITSVGSGSTSSTGLTGSYIPSFLKKEVGSVMQRVQLAPLAAPSPGYSSLKAVRPHPGRPFFHTQPRSTPGLIPRPPAVQPVHGRIDWSSKYPSRR
The following text describes a protein:
Function:
Voltage-gated, high-affinity calcium channel that functions together with MID1 to mediate calcium entry into cells. Required during conditions of environmental stress.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAEDIPLEEVEGSGRRWSSNNPFLDPGSGTRRAASRSNSSLSSVESGSTTDNPSIASIRQGLTTALGEGGSGGEWLTSEQIHNDEKLSPKKRRTSVFEESPKSTKGGLKRPEVGWNPSSSDYLTPNRTVDFELESLDNIAYTPKRYTSFDSADPMMHNDLRNTDLERAVSRNSPKSKDNTGDKWNNLTSAVQRVSYRIISGMEQIDPDEIVTDEEDRESSDGTIDGDEEDPFTQYDHLRPSSPLRPTSPVRPSPHRFNSNTSSRRPTTPKNDYDDPSQYLFGRSLRIFPPQHPWRWKMWKLCSSPWFEPFVLLLIILHTVFLFCESSWNIFKDKDTEHIFASWGHKWTDWGFLAIFILYTFEISAKIVAFGLWDDSQMFYSTGQMPDSSWNRFFPNKLTKSSRWNQRKGTSSAPISHALTLLVHNEQPTHRVQRAFLRSSWNRVDFISVVCYWISLGVAAHDYDIIHQLFLFRFLACLRILRLLNLTHGTTAVLRALKTSAPLLINVSLFIGFFWVTFSIIGTQSFKASLRRQCVWVDSTGQQDNYTYEQYCGGYLHPETLEHMPYVFTDGTVGPQSKGYMCPAGSICVSDKNPYGGTVSFDNIFNSLEMVFVIISLNTFTDIMYYTMDSDYMTACLFFMAGILILALWLANLLVAVIATSYSQIRVEMILSRKSKTETLFRKRLTSAEARNFLKKTVKGRWYLRMEWLWSLIIFMSLVVSSTRTADTTDSQETALYILEIIITSMLTADVILRFYVYLPNWRIFFLNIANVVDCALGVMCIVILIPPIHNKPVLYGWLTIFQILRIYRVVMFFKFTRLLWRRVVGNYRTMFYMSCFFFLLTFLCSVMSTRLLRGVIPQEDDSGESIEFSFYNLQNTFLGMYALSTTENWTDMLYNGQQFATNTFSALCIAAFFIGWFIFSNNVVMNLFIALITENLDVSEETKRIEQIKGFVRKYTDQISNNGGSLPTMQLLMQKVKHLGKNREINQTDGSHVFDMLMQRHVVQDFLEDEVNEAEEMPAEQRSRPSRIKRMLKQAHVKSLMFWRKKEPTENPFLDPPQGGDFFSRKKSLNPINLAKDFLDDYQQRLKTQEEFLAEHPDFNVVLYCLPPHNPIRRFCQRIVMPSHGTRHDGVIPKQWVWYTFTFIMFLATVALVVLACVATPLYQKENGGGGVWSWITWSDLGFLILFSIEAIIKILADGFYFTPNAYLRSSWGVIDFIVLISLWINMIAIFAGNGYVSRAVRAFKALRALRLLNISNAAKETFENIVIVGIRKIFGAAMISMCLLYPFSVWGLQIFKGRFYSCNDENTEFLANCINEFASSPSNWNVLAPRSVVKPYYDFDNFGHSFLILFEIISLEGWTDVLKTTMSIQGPGMNLEWAASVNNSAFLVLYNFISTVFILTLFIAVIIKNYSRTTGTAFLTQEQRAWAEAEKILKLVKPSIVPVYVREGTWREYCYRVVTNRKGKWNKFLAGLLFIHLIILCLEWYPQYLYAEDIRNGLFLPILIILDLNEIMRFYAFGYKGFMSRKWDLYTVLVVTGALVTTIFSFASFVSNTYYNFQKLCQVGILLLFIPRSERLDQLFKTTSASFASILNLMATWIVLFVVYAIAFNQIFGLTRVGPNGTGNINFRTVPKALILLFRMSCGEGWNQIMSDYLLEPPYCINGAGFNETDCGSRPYAYLLFISWNILSMYIFVNMFVSLIYENFSYVYQQTGPLSRAIKREELRKYKKAWREFDPTGTGYIRPDELHRFLRRIEGTFSMCIYEGDWSIKELISDHNIRVNDHDPYDVDLPALNKAVRTIPVGDMINRRRAFDTLCEQVLLERNPDKGISFSQVLLAIPIYKMVDENKCFMLDAYLKRRIMLQQVEENLLKAKLRGFMDMVQLRREFHERRDDMGPMSASRDPFESTGVTRIPSGSRKNIVPQIFITTDGDSKEDFTSEEPSLLPRKTADFDVEEVPTTPDGVPVPADYFLSTDPMTPNPNAGSSGRFSWASERSNIDRNSMWDRRVSGDSDNFKDQDSSDLNLIHRQEDQLIDSFENSVWGGALSKRASRYQRAEQDDEKDETLDDDSHDYI
The following text describes a protein:
Function:
Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol. Secreted. Endoplasmic reticulum. Golgi apparatus. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Secreted in response to hypoxia. Also secreted in response to both apoptotic and necrotic cell death.
Sequence:
MANNDAVLKRLEQKGAEADQIIEYLKQQVSLLKEKAILQATLREEKKLRVENAKLKKEIEELKQELIQAEIQNGVKQIPFPSGTPLHANSMVSENVIQSTAVTTVSSGTKEQIKGGTGDEKKAKEKIEKKGEKKEKKQQSIAGSADSKPIDVSRLDLRIGCIITARKHPDADSLYVEEVDVGEIAPRTVVSGLVNHVPLEQMQNRMVILLCNLKPAKMRGVLSQAMVMCASSPEKIEILAPPNGSVPGDRITFDAFPGEPDKELNPKKKIWEQIQPDLHTNDECVATYKGVPFEVKGKGVCRAQTMSNSGIK
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MADQSKGVKLYGTSFNGHTTMVECALRLKGVAYEYVEEDRKNKSEALLKLNPVHKQVPVLVVDGKPIAESQIILQHIDDVWKDPPHLPEDPYKRAKVRFWVDFVNKKVVPIMHTIVTLKGDEQKTAADEFGGYLQTMEDGIREELWTGGPFINGDNPGLLDVVMGSSYTWIKFIEAVAGVKLAKREETPLLCSSMEAFVELDAVKELMTPPEVLLQSRGNPGAKTTETSDD
The following text describes a protein:
Function:
Cilium-specific protein required for cilia structures.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MNPCKLKEPKVIDNALLEKCIKDQGPKGEAGRLAEIEKIPLEDVTEIRLEFLNILRIDHLWVLTSLTKLNLNNNLLEKIENLESLVNLTELNLSFNKIAKIENLDELRNLEKLSLYDNEITVLENMDTLTKLTVFSIGRNKIDDLDNILYLRRFGNLKSLNLVGNPCAEDEDFRLFIAVFLPQLVYYEYKLIYESERELGHETFSAKLRALLEKEEKEREITAIKEQELADAELHASSFVEYLNTRHLFDSLFANDTDGMNLMKIGEDAQEFYDEYEENFIELCKQIFENGQQQYILRKTEQDQFLKCVEDANKDNQDESIKHMEIFLEKKAILFLKIKNVQNQLNSNEINYDEFIDKCDVFVVEYDEMLHEVWKALMKLELELYEQMEEVNQTFEHNITELVNNFIESSQAFFTQIRELEVSYAENIGDLATKFQTNANLNEEIEVPAVLKPLMADKDLLHNALATSHDMHMQIIDAREDTLISNAKDWLNDLIDDLNTNEIKRNRGKVLEINHFLEIQRQEFEDLNKEYAPDLEDDVIALE
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Required for PhoD secretion. TatCd promotes membrane localization of TatAd via domain specific interactions. TatCd is required for stabile production of TatAd as well as for its maintenance.
Miscellaneous:
MISCELLANEOUS: B.subtilis possesses two minimal, substrate-specific, Tat translocases: TatAd-TatCd and TatAy-TatCy, each one composed of a TatA and a TatC protein. TatA is bifunctional and performs the function of both the TatA and TatB proteins of Gram-negative organisms.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWLIRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLMYIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGFLFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVLFEVSVTLSAFVYKKRMREETAAAA
The following text describes a protein:
Function:
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
Subcellular Localization:
Cytoplasm.
Sequence:
MLFTLDDILGATGGEIVAGGETIGASGVSTDSRTVEPGELFIPLRGERFDGHDYLDAARARGVRLTLVERQWLAGRQLPADVTCIVVDDTLRALGDLAACHRRRFDIPVVAVTGSNGKTTTKEMLAAILARTGEGLKTEGNLNNLIGVPRMLFRLSGVHRWAVLEIGMSEFGEIDRLAEIVRPDVGIITNAYPAHLETLGSVEGVARAKGELFLRLEPGSSAVYNADDPLIARCPSPEGVKRVSFGLRGGDVTAEDVENLGKKGQRFTLRLPNGRVTVTLHAFGSHNVANALAAAAAARVLGVAPEEIARGLGEFMPYARRFNLEEVGDVVLIDDSYNANPASMAAALTTLREIKGSGRAVAVLGDMLELGIGAEEAHRQLGRLAATCVDRLYVLGAMAGTVAAGALEGGLEERHVTIAADHGEIVADLRRTAATGEMILVKGSRGMAMDRVAEGIREAFAASGGKGGHV
The following text describes a protein:
Function:
Catalyzes the production of homocysteine from O-acetylhomoserine (OAH) and hydrogen sulfide (H2S), a step in the methionine biosynthesis pathway. Is not able to form cystathionine from O-acetylhomoserine and L-cysteine.
Sequence:
MDWKKYGYNTRALHAGYEPPEQATGSRAVPIYQTTSYVFRDSDHAARLFALEEPGFIYTRIGNPTVSVLEERIAALEEGVGALAVASGQAAITYAILNIAGPGDEIVSGSALYGGTYNLFRHTLYKKSGIIVKFVDETDPKNIEEAITEKTKAVYLETIGNPGLTVPDFEAIAEIAHRHGVPLIVDNTVAPYIFRPFEHGADIVVYSATKFIGGHGTSIGGLIVDSGKFDWTNGKFPELVEPDPSYHGVSYVETFKEAAYIAKCRTQLLRDLGSCMSPFNAFLFILGLETLSLRMKKHCENALKIVEFLKSHPAVSWVNYPIAEGNKTRENALKYLKEGYGAIVTFGVKGGKEAGKKFIDSLTLISHLANIGDARTLAIHPASTTHQQLTEEEQLKTGVTPDMIRLSVGIEDVEDIIADLDQALRKSQEG
The following text describes a protein:
Function:
Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.
Sequence:
MKNEIAAVVFFFTRLVRKHDKLKKEAVERFAEKLTQILQEKYKNHWYPEKPSKGQAYRCIRVNKFQRVDPDVLKACENSCILYSDLGLPKELTLWVDPCEVCCRYGEKNNAFIVASFENEDENKDEISKKVSRALDKVTSDYHSGSSSSDEDTSKEVDVKPSSVAATPSPVYQISELIFPPLPMWHPLPRKKPGMYRGSGHQTHYPPPVPFAYPNPGRKNKPFRPIPVTWVPPPGMHCDRNHWINPHMLAPH
The following text describes a protein:
Function:
Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MGGKRKRTESSVAAQSGGVKPNHKAPHGNKKHKGTAAKKVSGSSLRKRQEKAAPAAKPTALANSNWLALKSKIQQKDQRHNGGKTQEKKHDLDVKAQKKRVKQEKQAKRMKTRTAEWVDNSVIVGMDCEMVGVGLSGKTSVLARCSIVDYEGNVLYDKHVRPVEKVTDFRTHVSGIKAKSLRHAIPFAQCLKEVGKLMQDKIVVGHALKNDFQALMFTPPKHLIRDTAYYRPYMRRKVNGTKLYPKSLKHLTEEVLGRQIQTGQHDSVEDARATLELYKREQYLWEKYLRTNKGGSSLVGVAPALPEKDTEDDGPKPLSAAAKAHLDSDDEDFSTGRGVMAVPDSKELAIMEYGE
The following text describes a protein:
Function:
Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. As part of the ATG8 conjugation system with ATG12 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity); May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note=The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. Under starved conditions, the ATG12-ATG5-ATG16L1 complex is translocated to phagophores driven by RAB33B (By similarity).
Sequence:
MTDDKDVLRDVWFGRIPTCFTLCQDEITEREAEPYYLLLPRVSYLTLVTDKVKKHFQKVMRQEDISEIWFEYEGTPLKWHYPIGLLFDLLASSSALPWNITVHFKSFPEKDLLHCPSKDAIEAHFMSCMKEADALKHKSQVINEMQKKDHKQLWMGLQNDRFDQFWAINRKLMEYPAEENGFRYIPFRIYQTTTERPFIQKLFRPVAADGQLHTLGDLLKEVCPSAVDPEDGEKKNQVMIHGIEPMLETPLQWLSEHLSYPDNFLHISIIPQPTD
The following text describes a protein:
Function:
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). Can inadvertently accommodate and process non-cognate amino acids such as cysteine and alanine.
Subcellular Localization:
Cytoplasm.
Domain:
Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
Sequence:
MEFSEWYSDILEKAEIYDVRYPIKGCGVYLPYGFKIRRYTFEIIRNLLDESGHDEALFPMLIPEDLLAKEAEHIKGFEDEVYWVTHGGKTQLDVKLALRPTSETPIYYMMKLWVKVHTDLPIKIYQIVNTFRYETKHTRPLIRLREIMTFKEAHTAHSTKEEAENQVKEAISIYKKFFDTLGIPYLISKRPEWDKFPGAEYTMAFDTIFPDGRTMQIATVHNLGQNFSKTFEIIFETPTGDKDYAYQTCYGISDRVIASIIAIHGDEKGLILPPIVAPIQVVIVPLIFKGKEDIVMEKAKEIYEKLKGKFRVHIDDRDIRPGRKFNDWEIKGVPLRIEVGPKDIENKKITLFRRDTMEKFQVDETQLMEVVEKTLNNIMENIKNRAWEKFENFITILEDINPDEIKNILSEKRGVILVPFKEEIYNEELEEKVEATILGETEYKGNKYIAIAKTY
The following text describes a protein:
Function:
Binds directly to 16S ribosomal RNA.
Sequence:
MAHHKSALKRIKQNKKKYLRNKHIRSTLRTFIKRVREAVEAKNADQARQALLAAIPVIDKAASKGVIHASNASRNVSRLTKLVNTLG
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MNSAEYFKLPLKMEDLLHVSEINSYVVEEVATTREIQCNIGSANSNLRKHGADQILNVFNLYYSVLTKHNELDVMIKQDVWTTLLSVMKEYASDLTVMLEKNDINDKKKELKILKMLSYVLVNLIEIFENSESKSLPDLVTPRKSRKGTKKKTTTLSWSWKNERDAALNVIMQLLQTEISRLWDPPVVEEEYVTLISNCCYTILEKQESAKVNSTKDIIFHIIGILIKKYNHSLGASVKVVQLIQHFEHLATVMADAVAFYVNEYQANTVASDIIREIARISPQELSRDSSSTRGYAVFLAELAEKIPFVISANISLLISHLDGESYVMRNAVLSTMGAIVVSLLRKDDLDESAKKSRDHFLDRLEAHVHDVNAFVRSKVIQICTYVIGEKAVPIARQPGLVELILDRLHDKSSNVRRNAVKFLASYMARNPYGADFDVEKLALTLENTNSTIKQLESTLDQEKPVVKVEDQDHDSQNHLSSEETMNEIEQKILQHKLVARYLQDSIGFVKQVQNAIPIISGLLGSKTPSDVLEAVDFFVTARSFGFNVSQNGIRKMLPLVWSREQAVKEGVIEAYKKLYLENTVGQNRKKDHKAIVQGLLSLVKGSTIGELTSVEELVREFMRKGLILKETIRLLWGYFIMAVNDVTQEDSHYALVILGMIAEEEKSFLANNISALVDTGLGLRGEDNLVLAKDTCHVLQKLYRRKKEIKIARLPEDHMIFERITTILCKGITNLKCKFWVPFSEEAVKLVYNLALSPEEVCKRIMQSIVKQLMPDINEGSTEDGHNEISPRLLSRFISYAGDVALCQLVHLDVTISKELKERRLAEDKAEENNRTISGNKKKINSSSDEDDLGLGGCVGAAADDAEMELIRQLCDSNVVTGNGMLAVCANFIVAVCGNSKKFNERGLQNAAAVALAKCMLVSSKFCEQHLQLLFTIVEKSQFPSVRANLAVALHDLTVRFPNLIEPWTGHLYSQLKDSSLEVKRNSIKVLTHLILNDMIKVKGQISEMAVCLEDSNKEISNLAKLFFSELSKKGNAVYNILPDIISRLSDVEVGVNEACFRSILKYVMSFIEKDRQCENLTEKLCYRFRAAKKLYENFSCFQHALVDDDVDSSFNTVLNKMKRFAKPETKALAEEFQDRLNESRNKGIENDVAAQRAASAKKTPRKSVSKRKNRKKPVNLSFEEDSDVELFDIDPDEVSVNVDSDIENLDPATPSRCKRSTTHKRKSRSILSAKKPSTISSRA
The following text describes a protein:
Function:
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
Miscellaneous:
MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSLQQKIKAYLKLGKLGVVSLLDLAAIAGAFLAYKHGISLLPIIPMLIGGTLASMGAMIINSGIEINRDKVMSRTSNRPTVVGYVSRKEVIVVGSLLAVLGTALGFIDNALTAFFIALGVIIYVFVYTILLKPRTWLNIVIGGFAGSAAAWAGYTSLTNSLTLEAFLLGFLIFMWTPGHFWSLALKYREDYINAHYPMLPAVVGITTSARAIATSNALMIPIVLLMGYYISLIALIVFSVLSALLLFLSYRLILNPTKEEAMKSFIFSNIYLMLILLSIIIIKLI
The following text describes a protein:
Function:
Oxidoreductase that binds mammalian estrogens with high affinity.
Sequence:
MSNSNPLKDSLVFQPIKVGDNTLSNRIVYCPTTRFRAAKGNEEPTYRHVPSDLMLKYYSDRAQYPGTLLVTEATLISNRAGGYDGCPKISTQEETKAWKKIVDAVHSKGSFLSCQFWFLGRVGYPSLLKHRKLDYLAPSPIYENEKHQKQAEKAGLPLREVTEQEIHDIIYNDYTIAAKNAIAAGFDFIELHGAHGYFIDQFLHECSNQRTDKYGGSIENRCRFVLELIDHLITIVGAHRLAIRLSPWAEVQGIVEKESPIPTFSYLINELQKRADQGNQLAYLSVVEPRVQGTITADIKTMKGDNEFVAEIWKGVLLRAGNYTYDAPEFKGIVADTSNNRTLVGFSRFFISNPDLVSKLKNNPSSLVKYDRKLFYEQFNWGYNTYGQDQPVDEEKERKKFPKVIGNIDEARL
The following text describes a protein:
Function:
Transcription factor that is necessary for cell cycle progression from G1 to S phase.
Subcellular Localization:
Nucleus.
Sequence:
MVEINLYLLPCQNLLSLALVLLAFVVGFYKYLYDGHLCLRVCCEHMTVFVWQVTVMKGSSRNKDHSTEGEGTGKRPKRKCLQWHPLLAKKLLDFSEEEEEEEEEEDIDKVPLLGADGLEQDADETEDDESSEQRARRPMNAFLLFCKRHRSLVRKEHPRLDNRGATKILADWWAVLDPKEKQKYTDMAKEYKDAFMKANPGYKWCPTTNKPVKTQTSTVTSRKKLWAFPSDSAKDIPSPRKVTKSEEMPQLNFGMADPTQMGGLSMLLLAGEHALTAQEVSSNTCQSDATDSTEVCQKSSLFQFAEISSNTSQLSSPEPVKHCGKSALFQLAEISSSTSHSGPDLTKQCGTSALFQLAEMCLASEGVKVKEPGKIKVEVSEDVTREVPEMEVEELEKTTIKDSCTGKMEQSEKLQNWDEAKAEELETVKCSDFTCLLKDSNPFERNDNTKDYMCRSPELSLAEMSILGLGKPEKLKKKKKKNKLDRHTNEKSTPKKPCKKRQSSESDIESVMYTIEAVAKGDWGAERLEETPRKKARPSSNVKGSMLDTKSPKKKVKSKEKKTSKEKPMETTKESKPPDFLSITANKEVPCEASDSIKVEPLTPTEEVVPQSLPEQVKTEDSDCVKKIETCGSRKSERSCKGALYKTLVSEGMLTSLRANVDRGKRSSGKGNSSDHEGCWNEENWAFSQSGTSGNKKLKRPKPKEEFVFGLAKLEEEFEKKFNSLPQYSPITFDRKNSSVPRKKRKVGSGSSEQPKSNKAILSEDRNPIELAWRNKICISALNTPEPVMMHEPLVGSQKRKARKTKITHLVRTADGRVSPAGGTLEEKPKDLPQSSLQKASSAETDCNSECSGNAETQENHSITSDMPAVSAFFSLAALAEVAAMENVHRNQRATPLPHDGQPNEMSQAPVLISCADQ
The following text describes a protein:
Function:
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Sequence:
MSVIDDIKANIDIVDLINSMGVGLRRSGRSFVGFCPFHPNTRTPAFHVYPDTQSFYCFGCHASGTAFDFVMRKQGLDFKGALELLAARAGIRLEPKNDAQRQEDARRARLLEINGIAARYFNYVLLNLSRGEPGRDYIARRGINQDAIDAFQIGYSLDDWNHLFSYLHEKKGYSVEDLITAGLVIPGERGPYDRFRNRIIFPIRNIRGEVIGFGGRALGDAQPKYLNTPETPLFKKSEVLYGLDLARDAIRTANRAIVVEGYVDVITAHQHGFRNVVAPLGTALSKAHINQLKRLTDQVYLALDADAAGQKATLRGLETIRTTSEEEGEGRMVTTAQGIVRLENDVTIRIIRLPAGRDPDEVIAADPQLWQTLVDQAAPVMDFYLEAYTAGLDMHDPTQQRQALERIIPLLSELDGAAQRVYVARVEQLTGVRSELIVDLIRTRLQPTRRSERNRTSRPSAPPLPATSPVSTTPLDEHRRHTEAYLLALALRYPSVNLAIENLLENLKKQHRDAGALFGAGLEDLLEEPLHQAIWQAYLATPLELRPTDPESLQFWVDTLGEPLSSEAKALLEVLNRRPDDVRFRHEAEQCARLIRKAQIMARIRRYKERLDELTDEEEIQQVLQHIRDLSSYAEQITRPRQSSTFPDLRNLLGQ
The following text describes a protein:
Function:
Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function. It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex. Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Endoplasmic reticulum-Golgi intermediate compartment membrane. Note=Associates with the ends of centrosome-nucleated microtubules.
Domain:
Extended rod-like protein with coiled-coil domains; The C-terminus is required for recruitment to the Golgi apparatus and endoplasmic reticulum-Golgi intermediate compartment.
Sequence:
MSSWLGGLGSGLGQSLGQVGGSLASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHDDQGGVTRWMTGWLGGGSKSVPNTPLRPNQQSVVNSSFSELFVKFLETESHPSIPPPKLSVHDMKPLDSPGRRKRDTNAPESFKDTAESRSGRRTDVNPFLAPRSAAVPLINPAGLGPGGPGHLLLKPISDVLPTFTPLPALPDNSAGVVLKDLLKQ
The following text describes a protein:
Function:
Involved in cytokinin-mediated development.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
Domains SOFL-A and SOFL-B are required for function in cytokinin-mediated development.
Sequence:
MLGSSSGCESGWTLYLDQSVSSPSPSCFRDSNGFDSRRRSKDSWDQNYVHQEEEEEEDDLSMISDASSGPRNISEEDSVKKINIVGLKKQCKREKKRRDYEKMNSLLDDTASSPLFNFPHMLQKSVGGNKIEQTFPESTLDYSQGFSATQFQDKTAFQEQCGYLHMETRF
The following text describes a protein:
Function:
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
Sequence:
MFVETQEEVPEIREPLRRVGITNLRTVAKINWKGREYTFLPLIEVTIDVPAEKKGIHMSRLVESITEAMSEAVEEEVAKVHSSLEELGKSVIERLEGKHPHKRAEVWIKTHLIIPRTTPASKKTSYEPYDVEVGVIKNEDGSFEKVLRVRVIGNTACPHAMANNNGKTHIQRAIGELEIRAPFEEEIPLEEMIDVVESSFSHPTYTLLKTVDENAVVQGMFANPKFVEDVAREIFAKAKERFRGRIHVRVISNESIHKHDVIAETWS
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.
Sequence:
MFGEKSNYRDAHFQPLKSGMASPPDAYHVSQVEDGERHLDGNPAFDRPLTVQFCSNDPDDFLRAAKHVAPFCDAVDLNLGCPQGIAKRGKYGAFLQEDQGLIARMINKLHEELEVPVTAKMRVLETKEKTLEYAKTILDAGASIITVHGRRREQKGHNTGLADWQMIRYLRESLPKDTVIFANGNILQHEDIAACLEATGADGVMSAEGNLYDPTIFAPPPPVGQEGQEYWRDRNGKGGYRVDAVMRRYMDIIHKHALGQQPPVRKPLWMPGDPEEPVKQEQTPSEEGEEEDGPPKKKQKRLSKAEQKKAKSSNPNLTAMQAHLFHMLRPLVSEHHNVRDALARSRTGDIDAFENVLALVEQAVKQGIQAYESSPPTDAPEPLPSTENLDPYESSLATVARCKRPYWVCQPYVRPLPKEAIEKGSMTVSKKEKKRMEEETKAVGLEVGGRVEEKDEKTGETLGKDSLEESERREGKGDEVVEEPREGVVCG