lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein: it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization. The carboxylated form binds strongly to apatite and calcium; The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development.
Miscellaneous:
MISCELLANEOUS: Sequence data obtained by MS from fossilized bones of about 21 thousand years old.
Subcellular Localization:
Secreted.
Sequence:
YLDHGLGAPAPYVDPLEPKREVDELADQMGFQEAYRRFYGTT
The following text describes a protein:
Function:
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.
Sequence:
MADPSAAAAAANPSPGAGEEGAACSPPSPSQRGRGKVVIVMGATGAGKSRLAVDLAAHFAGVEVVSADSMQLYRGLDVLTNKVPLHEQNGVPHHLLSVIDPSVEFTCHDFRDHAVPIIQEILDRGGLPVIVGGTNFYIQSLVSPFLFDDMAEEMHDCTLREHIDDDRGLTNDDEDSGYERLKDIDPVAAQRIHPNDHRKIKRYLELYATTGSLPSDLFQGEAAKKWGRPSNSRFDCCFLWVDADLQALDSYVNKRVDCMMDAGLLNEVCNIYDADALYTQGLRQAIGVREFDEFFRLYLPRQESGEDSSANLLDIHDDQLKSLLDEAVSQLKANTRRLVRRQRRRLHRLGKDFGWNLHHFDATEAFCCATGDSWQKKVVEPCVDVVKRFLSDDSTVLPSTSASDGVVGSVRGPSRELWTQYVCEACDNRVLRGAHEWEQHKQGRGHRKRVQRLKQKSLRPRPLLSQDCN
The following text describes a protein:
Function:
Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome.
Sequence:
MARVKMHFFLLSAFFILFEFNFFELSTSYEFTAPLPGTPLNDEEYEKFFSLLMPEPIARSLCALRLGHGCEERTIRRYDAYENHGAVPTGPICTDLKTSSHFDNFCDFARFRCFHMLHYVKRIPCEEQEQQTIQTPTATPAKDPSLKSQLPQEITTETKPAGVTDKVQYKPMKIKPVTVGYKTTASIKAQSQQQTTPQKKTVGPKLGVDVSKLQTNVMASLKYKNDPVNGQDKAEMLAKPRDEASTVSHNPATSIPESTRIQGTEYPKEYQTANDEQNMTEEPEPQDSQLAKSKITVKEKQDFKAIDIDETSEESDSDDDIIGFVRPKNPPSSGHETTVTHKPTKAPSHQREMAKVENVKTQQDSYEHKKLNKLEMAWANMIENPANIKGTTRKPQDIEETPEDSDRDNDIIGFSGPQNPPKSREETIKGIHKTTKAPSHQRAMAKVENVKTQQDSNGNKKLNKLEMAWANMIENPANIKGTTRKPQDIEETSEDSDRDNDIIGFSGPQNPPKSREETVKGIHKTTKAPSHQRAMAKVENVKTQQDSNGNKKLNKLEMAWANMIENPANIKGTTRKPQDIEETSEDSDRDNDIIGFAGPQNPPE
The following text describes a protein:
Function:
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MANNPLSPDSILHHMAEALPTHQKNDTNSDISSSYEAIALFCHACMIAVGFRLLGFGEGQKNEAECAQLSPRLSTKWNSSFGSHSFLYAHSQSSMQYVVKVDRLGGKAEIRGIGLGDERITRFEITAKDYISSAALPLRIPFSNDEEDRTNLESKLQEIFISPSRIADLASLFKINIIQKLLPSLQKEGYEESRNQGESEASRVHDEREEQHARRNPPRNPLADPNLPAPARPYPFHDPLADQPRRPIPAGDFPPPGFDDELDLNRPLRGMVQPAGSPFNIGHDDLHPPGLGPNDPLRGSFTGGRGAGGLGGFGGMHPTFDDPLFAGQGQGQRGTGRNGGFNPQVPPGARYDPLGPGDGPQRGGGGRPPNPFGGFGSGDFI
The following text describes a protein:
Function:
Required for ovule fertilization.
Subcellular Localization:
Nucleus.
Sequence:
MASNNPHDNLSDQTPSDDFFEQILGLPNFSASSAAGLSGVDGGLGGGAPPMMLQLGSGEEGSHMGGLGGSGPTGFHNQMFPLGLSLDQGKGPGFLRPEGGHGSGKRFSDDVVDNRCSSMKPVFHGQPMQQPPPSAPHQPTSIRPRVRARRGQATDPHSIAERLRRERIAERIRALQELVPTVNKTDRAAMIDEIVDYVKFLRLQVKVLSMSRLGGAGAVAPLVTDMPLSSSVEDETGEGGRTPQPAWEKWSNDGTERQVAKLMEENVGAAMQLLQSKALCMMPISLAMAIYHSQPPDTSSVVKPENNPPQ
The following text describes a protein:
Function:
The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.
Sequence:
MCKINIKSFFSIIISKMVLKLSKTLFKGGTNFPGKVALKLDKKILKTVAKDYKVILVTGTNGKTTTTSMIYNMIKDSNKFVISNSTGANMFPGIVACFVENFSFNNKEEKYAVIEVDEANVKFITEYVSPEIITITNLFRDQLDRYGEVYTTLKKILEGIEKSPNSKLILNGDESLLGDLNNSLPNKVLYYGFSHFKNADTVIDVNADSKFCKKCKHPYSYEFLTYNHLGSYYCENCGYKRPNITFSLDEVEDLTPEGSLVIIDNQEYYINQPGLYNVYNALCAYSMAKTLGIEKSIIFNSLKSQKSSFGRQESINIEGKDVKIILVKNPAGYDQAINTIVLDKKKLNLALLLNDNYADGRDVSWIWDVKFEKLKSLDIDNILISGVRLYDMAIRLKIAGLPNEKFKISQNHDDLLEDIKSCREETVYILATYTAMTSFRKFLNSKGYIKKLW
The following text describes a protein:
Function:
Involved in the control of mitotic chromosome transmission. Required during cell division for faithful partitioning of the ER-nuclear envelope membranes which, in S.cerevisiae, enclose the duplicated chromosomes.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Attached to the cytoplasmic surface of the ER-nuclear envelope membranes.
Sequence:
MSEEQTAIDSPPSTVEGSVETVTTIDSPSTTASTIAATAEEHPQLEKKPTPLPSLKDLPSLGSNAAFANVKVSWGPNMKPAVSNSPSPSPSAPSLTTGLGAKRMRSKNIQEAFTLDLQSQLSITKPELSRIVQSVKKNHDVSVESTLSKNARTFLVSGVAANVHEAKRELVKKLTKPINAVIEVPSKCKASIIGSGGRTIREISDAYEVKINVSKEVNENSYDEDMDDTTSNVSLFGDFESVNLAKAKILAIVKEETKNATIKLVVEDEKYLPYIDVSEFASDEGDEEVKVQFYKKSGDIVILGPREKAKATKTSIQDYLKKLASNLDEEKVKIPSKFQFLIDAEELKEKYNVIVTFPSTPDDELVSFVGLRDKVGEAITYARSSSKSYVVESLDISKAHSKNLTHAKNLIMYFTKYSVLKGLEESHPNVKISLPSIQSLPTAETVTIHISAKSDEANDIKAVRKELISFVNNIPPSETLVITDLDYELFGGSIKHCLLASESSVAFVQFGDYYPNDNSILLVALTEDEDFKPSIEEIQASLNKANESLNSLRTKQNNMETKTYEFSEEVQDSLFKPSSATWKLIMEDISEQEGHLQIKLHTPEENQLTVRGDEKAAKAANKIFESILNSPSSKSKMTVNIPANSVARLIGNKGSNLQQIREKFACQIDIPNEENNNASKDKTVEVTLTGLEYNLTHAKKYLAAEAKKWADIITKELIVPVKFHGSLIGPHGTYRNRLQEKYNVFINFPRDNEIVTIRGPSRGVNKAHEELKALLDFEMENGHKMVINVPAEHVPRIIGKNGDNINDIRAEYGVEMDFLQKSTDPKAQETGEVELEITGSRQNIKDAAKRVESIVAEASDFVTEVLKIDHKYHKSIVGSGGHILREIISKAGGEEIRNKSVDIPNADSENKDITVQGPQKFVKKVVEEINKIVKDAENSVTKTIDIPAERKGALIGPGGIVRRQLESEFNINLFVPNKDDPSGKITITGAPENVEKAEKKILNEIIRENFDREVDVPASIYEYVSERGAFIQKLRMDLSVNVRFGNTSKKANKLARAPIEIPLEKVCGSTEGENAEKTKFTIEEVGAPTSSEEGDITMRLTYEPIDLSSILSDGEEKEVTKDTSNDSAKKEEALDTAVKLIKERIAKAPSATYAGYVWGADTRRFNMIVGPGGSNIKKIREAADVIINVPRKSDKVNDVVYIRGTKAGVEKAGEMVLKSLRR
The following text describes a protein:
Function:
Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus outer membrane; Multi-pass membrane protein.
Sequence:
MLEQIHLLAAVTVLGVLEQAYFFLQVIHARRKFGISPPNISGPPEFERIFRAQVNSSEYFPIFVALLWQAGLFFHQGLAAALGLLYLYSRYCYFMGYRASSSDRLTPIYFSTGVLWVLIAAATLGLLHFFLSHYVGLNVLQAHLTVLPIPVEPAGPQGQHSVPSCSIWLMAESSPKQGEFLENRTWRSKHFSAPASSPGTVGSVQPPTVHSQEGNF
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Catalyzes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, IKBKE, MLST8, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases (By similarity). Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR (By similarity). In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE (By similarity). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked ubiquitination of MLST8, thereby inhibiting formation of the mTORC2 complex, while facilitating assembly of the mTORC1 complex. Required for normal antibody isotype switching from IgM to IgG.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: On mRNA level, has a significantly shorter half-life than isoform 1.
Subcellular Localization:
Cytoplasm.
Domain:
The coiled coil domain mediates homo- and hetero-oligomerization; The MATH/TRAF domain binds to receptor cytoplasmic domains; The RING-type zinc finger domain is essential for E3 ubiquitin-protein ligase activity. It is not essential for the stabilization of BIRC2, or for the ubiquitination of RIPK1 in response to TNFR1 signaling.
Sequence:
MAAASVTSPGSLELLQPGFSKTLLGTRLEAKYLCSACKNILRRPFQAQCGHRYCSFCLTSILSSGPQNCAACVYEGLYEEGISILESSSAFPDNAARREVESLPAVCPNDGCTWKGTLKEYESCHEGLCPFLLTECPACKGLVRLSEKEHHTEQECPKRSLSCQHCRAPCSHVDLEVHYEVCPKFPLTCDGCGKKKIPRETFQDHVRACSKCRVLCRFHTVGCSEMVETENLQDHELQRLREHLALLLSSFLEAQASPGTLNQVGPELLQRCQILEQKIATFENIVCVLNREVERVAVTAEACSRQHRLDQDKIEALSNKVQQLERSIGLKDLAMADLEQKVSELEVSTYDGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLDHNNREHVIDAFRPDVTSSSFQRPVSDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL
The following text describes a protein:
Function:
Transcription factor. Down-regulates expression of genes involved in either the synthesis or reuptake of serotonin, dopamine and GABA. Acts as a transcriptional repressor to regulate multiple, discrete, neuron-specific aspects of terminal differentiation, including cell migration, axonal development and gene expression. Promotes touch receptor neuron differentiation by repressing the expression of egl-44 and egl-46. As egl-44 and egl-46, probably acting as a heterodimer, repress expression of zag-1 in FLP neurons, together these proteins form a bistable, negative-feedback loop that regulates the choice between neuronal fates. Required for axon guidance. Involved in the proper development of the pharynx. Required for pharynx isthmus peristalsis, probably via a role in the differentiation of the M4 cholinergic motor neuron. Directly represses its own transcription by interacting with conserved E-box sequence motifs 5'-CACCTG-3' in its own promoter. May also act as a transcriptional activator of the homeodomain ceh-28.
Subcellular Localization:
Nucleus.
Sequence:
MVDIAEAMPTTASSLPSDEALRKFKCPECTKAFKFKHHLKEHIRIHSGEKPFECQQCHKRFSHSGSYSSHMSSKKCVQQASPSMVTPFNPYQLMMYRNIMLQLQTPQVSFLPSTAANNMDYMSLLQANLFQSLENGTSPTPTQEPSAPASPEPKIEVVDEPEVSSEVKTEVKTEVKTEDSVPEESITPAVSMSLSPAPEQNGNESMNNGGSGSDGKSSPDWRPLRSRSFLNDSQVAVLQNHFKRNPFPSKYELSAVAEQIGVNKRVVQVWFQNTRAKERRSNRLPSMPRGSVASAAAAAATSPTVWQTPVQLMAAWASQFSNGNNSLTASQDERNNENTDEVMDHDGLKDGKETPLDLTLSTDDTEPEWSPEKLIGFLDQTGGVIQELLRQAGNGFVTNQEDEEEKPIKAEESPVSSGSSSIWPSFIGQYPSILDSASLSVLEKALDQQKSSEDDASSLCSNESKLLKFPTTPLKEEEGLFSCDQCDKVFGKQSSLARHKYEHSGQRPYKCDICEKAFKHKHHLTEHKRLHSGEKPFQCDKCLKRFSHSGSYSQHMNHRYSYCKPYREQPASPSDVLNGGSVTVSPSSSNTPPPST
The following text describes a protein:
Function:
Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox.
Subcellular Localization:
Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The PX domain mediates interaction with phosphatidylinositol 3,4-bisphosphate and other anionic phospholipids. In the autoinhibited, unphosphorylated state an intramolecular interaction with the C-terminal SH3 domain precludes phospholipid binding and interaction with CYBA. Phosphorylation disrupts the autoinhibited state.
Sequence:
MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRKFTEIYEFHKMLKEMFPIEAGEIHTENRVIPHLPAPRWYDGQRAAESRQGTLTEYFNSLMGLPMKISRCPHLLNFFKVRPDDLKLPNDSQVKKPETYLTAKDGKNNVADITGPIILQTYRAIADYEKGSKTEMTVATGDVVDVVEKSESGWWFCQMKTKRGWVPASYLEPLDSPDEAEDPDPNYAGEPYVTIKAYAAVEEDEVSLSEGEAIEVIHKLLDGWWVVRKGDITGYFPSMYLQKAGEEITQAQRQIRSRGAPPRRSTIRNAQSIHQRSRKRLSQDTYRRNSVRFLQQRRRPARPGPQSPDSKDNPSTPRAKPQPAVPPRPSSDLILHRCTESTKRKLTSAV
The following text describes a protein:
Function:
Involved in several stages of intracellular trafficking.
Sequence:
MSQLRRIMEEHQQEAGKESKPSSTSVDLQGDSPLQVEISDAVSERDKVKFTVQTKSGLPHFAQPEFSVVRQHEEFIWLHDTYVENEEYAGLIIPPAPPRPDFEASREKLQKLGEGNSSITREEFARMKQELEAEYLAIFKKTVAMHEIFLQRLAAHPTLRRDHNLSVFLEYSQDLSVREKNRKEVLGGFLKSIVRSADEVLITGISGLKEVDDFFEHERTFLVEYHTRIRDTCQRADRVMHSHKCLADNYIPLSAALSSLGTQAVNQLKRSFLKLAELFERLRKLEGRIASDEDLKLSDMLRYYMRDSQAAKDLLYRRLRALADYENANKALDKARTRNREVQPAESHQQLCCQRFERLSDSAKRELMDFQSRRVSSFRKNLIELAELELKHARASTLLLQNTLVALKGEP
The following text describes a protein:
Function:
Binds together with bS18 to 16S ribosomal RNA.
Sequence:
MARKYEIMYIIRPNIEEDEKKAVVERFDGILTENGAEIIESKEWGKRRLAYEINDYRDGFYHIVKLNADKADSINEFDRLAKISDDIIRHMVIKEEA
The following text describes a protein:
Function:
Catalyzes the reversible oxidation of (S)-malate and (S)-sulfolactate to oxaloacetate and sulfopyruvate, respectively. Can use both NADH and NADPH, although activity is higher with NADPH. Oxidation of (S)-sulfolactate is observed only in the presence of NADP(+). Can also oxidize tartrate. Cannot reduce pyruvate, nor alpha-ketoglutarate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKVTIIGASGRVGSATALLLAKEPFMKDLVLIGREHSINKLEGLREDIYDALAGTRSDANIYVESDENLRIIDESDVVIITSGVPRKEGMSRMDLAKTNAKIVGKYAKKIAEICDTKIFVITNPVDVMTYKALVDSKFERNQVFGLGTHLDSLRFKVAIAKFFGVHIDEVRTRIIGEHGDSMVPLLSATSIGGIPIQKFERFKELPIDEIIEDVKTKGEQIIRLKGGSEFGPAAAILNVVRCIVNNEKRLLTLSAYVDGEFDGIRDVCIGVPVKIGRDGIEEVVSIELDKDEIIAFRKSAEIIKKYCEEVKNL
The following text describes a protein:
Function:
Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ.
Subcellular Localization:
Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Secreted, extracellular space, extracellular matrix.
Sequence:
MNKLGFAMERVWLLLLLTIKVLSVTTQFNGYNCDASLHSRFPAERDINVYCGVQAISMKINFCTVLFSGYSETDLALNGKHGDSHCRGFINNNTFPAVVIFIINLSTLEACGNSLMVTSVPGVNAYGNISTVQIGNVSGYIDTPDPPTIISYLPGLLYKFSCSYPLEYLVNNTQLASSSAAISVRENNGTFVSTLNLLLYNDSTYSQQLIIPSIGLPLKTKVFAAVRATNLDGRWNVLMDYCYTTPSGNPNDDLRYDLFFSCDKDPQTTIIENGKSQMGRFSFEVFRFVKHKNQKMSTVFLHCVTKLCRADDCPFLAPICSNRKRRDVAKITTWSPQSTSGSAVITAGPIITRTDETPTNNSQLGNPNGSSFQLNSVTSALISGIVILGIMSTVFFTFSLLLLHRKWPSSSPVLSGVRNPVFN
The following text describes a protein:
Function:
Amino acid transporter that mediates the uptake of the L-enantiomers of various amino acids, including L-glutamate (Probable). May play a role in promoting fertility.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Note=Co-localizes with nrfl-1 at the apical cell membrane of intestinal cells.
Sequence:
MLNVFGVSASMPDDSRSQKMGLLGAISYIVGNIVGSGIFITPTSIIENVNSVGLSLAIWILAAFISMLGSFCYVELGTSIRLSGGDFAYLCFMKWYPVAFAFMCIGCTINYPATLAVQAQTFAEYVFRGAGVELDETSEFWAKKLLGFSLIILLMFMNFFSLKTFVQRFSILASLAKIAATLLIIITGFYYLIFKHWKQNLEEPFKGSNWNPGPFVNALFAGLFSYDGWDILNFGAEEIENPKRTMPLSIIIGMTCIGVIYVAVNVAYSIVLSPTEMIASNAVAIDFANKTLGAAAFVVPVMVAILLIGSLNSTMFSASRYLQAVSRQGHIPSAISGIAPNCDSPRVALLVHILIAIAVSFLGDPDKLINYVAFAQWSQRAFTMSALLYLRIRGRPRHPDRIQLPIIMPILFFLVCTSMVVISIIDDFKSSAVGLGILLGGLIIFIIFVWDRALPSSHTFRNATHVINEESTKFMQIIFNVVPERVGDEEMKNAIGGAESESEKVPAYKISPTGNGQFKCTRM
The following text describes a protein:
Function:
[Isoform AltDDIT3]: Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MLKMSGWQRQSQNQSWNLRRECSRRKCIFIHHHT
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTLGAATANDPIDSTLASPSRDEQRRQANQAAFSRDLEFLSSLANPYYLNHLALSGALSSPSFKRYLKYLDYFRHPKYVKYLHYPQALHFLDLLQNEEEFRLACRDPAFAGEVMAKQIGHWATWRDPENAAGQEQDEAGEQGEARETTGGQTA
The following text describes a protein:
Function:
A low activity DNA endonuclease yielding 3'-hydroxyl ends (Probable). Expression of a repaired protein increases the frequency of recA-independent recombination, but also decreases viability probably via DNA damage as measured by induction of the SOS repair response; in a RecA strain expression has no effect on viability but does induce the SOS repair response. RecA-independent DNA recombination leads to replacement of recipient genes with large segments of donor DNA rather than DNA addition to the donor strain; increased expression of RpnD leads to smaller replacement segments, suggesting this protein may play a role in generating crossover events. Upon expression enhances RecA-independent DNA recombination 4.7-fold, concomitantly reducing viability by 94% and inducing DNA damage. May play a role in horizontal gene transfer.
Sequence:
MTNFTTSTPHDALFKTFLTHPDTARDFMEIHLPKDLRELCDLDSLKLESASFVDEKLRALHSDILWSVKTREGDGYIYVVIEHQSREDIHMAFRLMRYSMAVMQRHIEHDKRQPLPLVIPMLFYHGSRSPYPWSLCWLDEFADPTTARKLYNAAFPLVDVTVVPDDEIVQHRRVALLELIQKHIRQRDLMGLIDQLVVLLVTECANDSQITALLNYILLTGDEARFNEFISELTRRMPQHRERIMTIAERIHNDGYIKGEQRILRLLLQNGADPEWIQKITGLSAEQMQALRQPLPERERYSWLKS
The following text describes a protein:
Function:
As component of a spoke-associated complex, regulates flagellar dynein activity by mediating regulatory signals between the radial spokes and dynein arms.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MAQPQRPYDALYDPNFTVAGPRDHYRQQTMAGGFNIERAPVYNNFFSELPHHPPSTLRLKNADRVPAFVDRNYRPAANDPNDTRQRSDALAVSGPNRPKYFRRPMLAAAEIHIKQAPPSQLPPLPSHQDLNATAPAAMGGAGGLGEPRSKTIGTQSDYRENEAQTAPWEPGYVLPAPGALTAKQAALMRRYHTDVPEVLQLKDLAFPDGLPAGLQEVTRIDKMRAKRAFEASLPPIDDVARLPLRQRMIEEWEAKEWEEREQEILSIQDKRLELLDNALQVREEELDDENRLRVEARKEAMLAGRAGKFADVQATRIKTMRQLIENRKYVEKHRKLHKPTIVERYANYGSGTYAPLQREGRFPESKPLGKEIETEGYAPVTLKGVVDLESFLPSRLLNPRVAAPQKPARLDYHQRKEAAVQRDLKAINDLLDTAKGTAGRGFGDCWPAPLQDDGGAGMGNGTLGRATSTVGKGTLGAGGSAGGAAPGGASMALLGGPSTAAASAMGPLASGVSGSPSRRVVRAIERPPTPELPQPPAVTAPQHAAVVLLQRLLRGRAAQNIMYEGRVRRQELIDELRLEEVVSADGTKIDGQPIRRPEHRDTATLRIDALVGSAVAEVAAILAETDPERRETLLAGLDVSRAHATAAAVAAAAADINASARAEAEEAAATAMAEAAAAAAAAAAAAAAAEDGGAEGAAESAAEAAAAAEAAASAAEEAYAGAVAAAAAPARAAALNLEALGISPEEAEEAAVRIQAAFKGHKARKEVAAMRARGEMLRNIMANGDEAKVVTCQAAIRGHLARKRVRQLRASQAGNEGFAGAPSASPEPAAPLPALAENQDQQEPQPQPQPSSSSGALDLADYDDHHGEASAAMLGGEPSLAVGGSREGEQQLEADAEAEAEAEAEAEAGAEAEASAQAGAEAEAEAGVEAEAEASAGAEASVGAGAEGDAEAETEAGAQAEPGPEAEAEAEAGAEAEAENGAEAEARLGGEEEGFREGEGQGGAAAGEAGPGGELAEGEGEAGEGEAAE
The following text describes a protein:
Function:
Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction.
Sequence:
MRKILITGGAGFIGSALVRYIINETSDAVVVVDKLTYAGNLMSLAPVAQSERFAFEKVDICDRAELARVFTEHQPDCVMHLAAESHVDRSIDGPAAFIETNIVGTYTLLEAARAYWNALTEDKKSAFRFHHISTDEVYGDLHSTDDFFTETTPYAPSSPYSASKASSDHLVRAWLRTYGLPTLITNCSNNYGPYHFPEKLIPLMILNALAGKSLPVYGNGQQIRDWLYVEDHARALYCVATTGKVGETYNIGGHNERKNLDVVETICELLEELAPNKPHGVAHYRDLITFVADRPGHDLRYAIDASKIARELGWLPQETFESGMRKTVQWYLANESWWKQVQDGSYQGERLGLKG
The following text describes a protein:
Function:
Transcriptional activator involved in defense responses against pathogens. Acts as a positive regulator of defense responses against the rice blast fungus Magnaporthe oryzae. Acts through W-boxes, which are cis-elements that are enriched in the promoters of several defense-related genes. Plays an important role in the benzothiadiazole-induced disease resistance by mediating salicylic acid (SA) defense signaling pathway, independently of the disease resistance gene NPR1/NH1. Acts as a negative regulator of defense responses against the bacterial blight Xanthomonas oryzae pv oryzae (Xoo) and the bacterial streak Xanthomonas oryzae pv oryzicola (Xoc). Acts downstream of abscisic acid (ABA) signaling in response to the rice blast fungus. ABA is a negative regulator of defense responses that interacts antagonistically with salicylic acid (SA) signaling pathway. Acts as a negative regulator of ABA signaling that suppresses growth of seedlings. Does not seem to be involved in the regulation of salt stress response. Acts as a negative regulator of cold stress response. Acts as a negative regulator of drought stress response.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing WRKY45 exhibit enhanced resistance to the rice blast fungus Magnaporthe oryzae. Plants overexpressing WRKY45 exhibit increased susceptibility to the bacterial blight Xanthomonas oryzae pv oryzae (Xoo) and the bacterial streak Xanthomonas oryzae pv oryzicola (Xoc).
Subcellular Localization:
Nucleus.
Sequence:
MTSSMSPAPAPAYAQVMEDMEKGKELAAQLQGLLRDSPEAGRFVDQILHTFSRAMRALDKAAVSAAGGEGSEVQSEVTCGGGASAGGKRKAPAADRKANCRRRTQQSSGNSVVVKNLDDGQAWRKYGQKEIQNSKHPKAYFRCTHKYDQLCTAQRQVQRCDDDPASYRVTYIGEHTCRDPATAPIIAAHVIHQVAAGDNDDGCGGLQAGSRLISFVAAPAAPVDAAAAPTTSTITTVTAPGPLLQPLKVEGGVGSSDQEEVLSSLTPGSSAARGGGGGGGVAGPFGPDQGDVTSSLHWSYDAVAGMEFFKNDEVVFDLDDIMGLSF
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Sequence:
MTQDEEMKDLPTPSQSIPSTLQHLKEIASIIETGSNLKEVRKISRAVRLTLALRSKLTAPVLSSFLHYVLPPHSTLSSYLPNSKGGDHEMEVDTATSAAIQTPAKHLLPELEIYCYFLVLLFLIDQKRYNEAKACSSASIDRLKNLNRRTVDVIASRLYFYYSYSYELTGDLAEIRGTLFQLHRIATLRHDELGQETLLNLLLRNYLHYNLYDQAEKLRSKAPRFEAHSNQQFCRYLFYLGKIRTIQLEYTDAKESLLQAARKAPVAAQGFRIQCNKWAIIVRLLLGEIPERTIFVQKGMEKALRPYFELTNAVRIGDLELFRNVAEKYATTFNTDGTNNLIVRLRHNVIRTGLRNISISYSRISLADVAQKLRLSSADPIADAESIISKAIRDGAIDATLDHANGWMVSKEIGDIYSTNEPQLAFNSRIAFCLNMHNEAVQALRFPKNTHKEKEIAEKRRERQQQEQELAKHIEEEDDDDDF