lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.
Subcellular Localization:
Nucleus speckle. Nucleus, nucleoplasm.
Sequence:
MASSAAKQPPKNASKAPSGGAGGAAAGAAAMPLASPLMGGLNKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPVDDRHAPPGKRTVGDQMKKSQDDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERRELREKEEIEKYRMERPKIQQQFSDLKRKLSEVTEDEWLSIPEVGDARNKRQRNPRYEKLTPVPDSFFAKHLQTGENHTSVDPLQGQFGGLNTPFPGGLNTPYPGGMTPDAGELDMRKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTDLNSMIPTYGGDISDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALENVSKSVRLWKTAVELEEPEDARIMLSRAVECCPTSVELWLALARLETYENARRVLNKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWIQDAEECDKAGSVVTCQSVIRAVIGIGIEEEDCKHTWMEDADSCVSHGALECARAIYAHALQVFPSKKSVWLRAAYFEKNNGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENNEYERARRLLAKARSSAPTARVFMKSVRLEWVLGNIEAAHELCTEALKHYEDFPKLWMMRGQIEEQSESIDRAREAYNQGLKKCPHSMSLWLLLSRLEEKVGQLTRARAILEKARLKNPQSPELWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAVFLEARPQRKTKSVDALKKCEHDPHVLLAVAKLFWSERKITKAREWFLRTVKIEPDLGDAWGFFYKFELQHGTEEQQHEVKKRCENAEPRHGELWCAESKHILNWQKNIGEILVLVASKIKNSF
The following text describes a protein:
Function:
Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere, M line.
Sequence:
MSLVAVPFYQKRHKHFDQSYRNIQTRYLLDEYASKKRASTQASSQKSLSQRSSSQRASSQTSLGGTTCRLCAKRVSTQEEEEQENRSRYQSLVAAYGEAKRQRFLSELAHMEENVHLARSQARDKLDKYAIQQMMEDKLAWERHTFEERISRAPEILVRLRSHTVWERMSVTLCFTVQGFPTPVVQWYKDGSLICQAAEPGKYRIESNYGVHTLQINRADFDDTATYSAVATNAHGQVSTNAAVVVRRFRGDEEPFRSVGLPIGLPLSSVIPYTHFDVQFLEKFGVTFRREGETVTLKCTMLVTPDLKRVQPRAEWYRDDVLVKESKWTKMFFGEGQASLSFSHLHKDDEGLYTLRIVSRGGVSDHSAFLFVRDADPLVTGAPGAPMDLQCHDANRDYVIVTWKPPNTTTESPVMGYFVDRCEVGTNNWVQCNDAPVKICKYPVTGLFEGRSYIFRVRAVNSAGISRPSRVSDAVAALDPLDLRRLQAVHLEGEKEIVIYQDDLEGDVQVPGPPTNVHASEISRNYVVLSWEPPTPRGKDPLMYFIEKSVVGSGSWQRVNAQTAVRSPRYAVFDLMEGKSYVFRVLSANRHGLSEPSEITSPIEAQDVTVVPSAPGRVLASRNTKTSVVVQWDRPKHEEDLLGYYVDCCVAGTNHWEPCNHKPIGYNRFVVHGLTTGEQYIFRVKAVNAVGMSENSQESDVIKVQAALTVPSHPYGITLLNCDGHSMTLGWKVPKFSGGSPILGYYLDKREVHHENWHEVNSSPSKQTILTVDGLTEGSLYEFKIAAINLAGIGEPSDPSEHFKCEAWTMPEPGPAYDLTFCEVRDTSLVMLWKAPVYSGSSPVSGYFVDFREEDAGEWITVNQTTTANRYLKVCDLQQGKTYVFRVRAVNANGVGKPSDMSEPVLVEARPGTKEISAGVDEQGNIYLAFDCQEMTDASQFTWCKSYEEIADDERFKIETVGDHSKLYLKNPDKEDLGTYSVSVSDTDGVSSSFVLDPEELERLMALSNEIKNPTIPLKSELAYEIFDKGQVRFWLQAEHLSPDASYRFIINDREVSDSEIHRIKCDKATGIIEMVMDRFTIENEGTYTVQIHDGKAKSQSSLVLIGDAFRTVLEEAEFQRKEFLRKQGPHFAEYLHWDVTEECEVRLVCKVANTKKETVFKWLKDDVLYETETSPDLERGTCQLLIPKLSKKDHGEYKATLKDDRGQDASILEIAGKVYDDMILAMSRVCGKSASPLKILCTPEGIRLQCFMKYFTEEMKVNWQHRDAKISSSEHMRIGGSEEMAWLQICEPTEKDKGKYTFEIFDGKDNHQRSLDLSGQAFDEAFAEFQQLKAAAFAEKNRGRLIGGLPDVVTIMEGKTLNLTCTVFGNPDPEVVWFKNDQDIELSEHFSVKVEQAKYVSMTIKGVTSEDSGKYSINVKNKYGGEKIDVTVSVYKHGEKIPDVAPPQQAKPKLIPASASAPGQ
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MMSFKTLIERGSHIHKPFKSMHNVPVQRISFNASNSVHLNSFSMIQSIRNLSCPAVPRKLNVAMVSRLRKETQCALSKAKDALVAIKAEIHPGTDQQIYDDALAWLHKDMAESGAKKAAKVSNRVTAEGLVGVFCDPRYGRHAAMVEINSETDFVSKSELFSKLVESVGLTVAQSPEIRSTIDESKLHASPIHEIDRSMILQSSMVASDTLSIQTAFADVIGKLGENLQLRRALLALQPFNSTHITSDHQQRVFGVYAHAAEKTKIAGLGKFAAVVSLTSAEPKVDLAESQILRMAIFANKLAQHITGFSPTSIYATPFHTDNNSQEIPATSSEGVLMTQQFLFGGGTVLEVLNAFSKEIKAKIVVEAFTRYACGEGIEKKPDNFVDEVMKQASQ
The following text describes a protein:
Function:
Involved in the early biogenesis steps of box H/ACA snoRNP assembly.
Subcellular Localization:
Nucleus.
Sequence:
MITPKFELRQDEEFVYLDVHTPYIKAKNVEIDAFNNEVNFCIAPYFLKLELPGNVLDDDRANASYDISSGFVHIKFPKETPGEVFPDLDLLTTLLVNQNKEPVKKPLIEEVEDTPSPSTSQNASKDEEKEVKIDWQNIHFDDPDFDWGLLQRLDDEKMQYTSTSQYGFNNQYSGLLKYNALVGNEINQIPEPERTPPSTRSEIRVQLEDEKFDAEHYMADFYDREMIDEILHYIPDYIGEFLLVQQGKSDRLLEFTSEEKEALAKLPKRSYLIDNPKNVYLCLVPLIFAYAYDNRTTLGDPTIESCWNIGTLSSTISCLDTNFLAIKDIFIACIRRSLAYPLYRNWDLALTCWKDTHAILSLGKRWILRVLLRIRNLFEHHDVYYIYNAIVLNDYAYWIQTANDNVLAALAYQVSECTITKEETNWPLEEIEANVQETIIASDEESESIEK
The following text describes a protein:
Function:
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
Subcellular Localization:
Cytoplasm.
Sequence:
MAIHADTHDDLRLFQTGEHACGYWSDRQARDLVLDPHDPRLGALYPQALAWGFRRSGDLVYRPHCERCRACVPVRIAVDAFHPDRSQRRCLARNQDLVVRVVAAERTEEQLALYRQYLQHRHPGGGMDTHGAAEFDQFLIGGWSHGRFLEIREPAVDHVPGRLLAVAVTDVTEHALSAVYTFYAPDAAARSLGTFAILEQIQWARRERRAHLYLGYWIEGHAKMNYKRRFNALEAYDGRHWRGLPAAQGSAR
The following text describes a protein:
Function:
Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.
Subcellular Localization:
Cytoplasm.
Sequence:
MTQLPFLRLSLPRQIPLCSPARSFFHTTAALQAVQASKKNQLTMATVNTKTGKVVDRTVLDSMLRRRLFYTPSFDIYGGVSGLYDYGPPGTALLNNIVDLWRKHFVLEEDMLEVDCTMLTPHEVLKTSGHVDKFADWMCKDPKTGEIFRADHLVEEVLEARLKGDKEARGQKVVVDEEKEAKKKKKAKDAKAVKLDDALVKEYEEILAQIDNFDGTQLEEIIAKHDIRNPTTDGNLLPPVAFNLMFQTSIGPSSNMPGYLRPETAQGQFLNFQKLLEFNQQSMPFASASIGKSFRNEISPRAGLLRVREFLMAEIEHYVDPEGGKKHHRFEEVKDIEMAFLNRNVQLSGCTKTEKMTIGKAVETGMVDNETLGYFIARIQLFLLKLGVDPNKLRFRQHMANEMAHYAADCWDAELLTSYGWIECVGCADRSAYDLTVHKNKTGAPLVVREPRAEPLKIEEWQVDLDKKKFGPRFKKDGKAVAAAVEALSQELREKLAIDLEKNGKIEVDVEGVGSGKVELDQDIVKIEKRTRVENVREYTPNVIEPSFGIGRILYSMIEHVYWAREEDEARGVLSFPPAIAPTKVLIVPLSTHASFRPLLQQLMTKLRRMGISNRVDDSSASIGKRYARNDELGTPFGITVDFQSVKDNTFTLRDRDTTKQVRASEDEILQAIKSLVDGEKTWEDIRKELPEFTGQEVD
The following text describes a protein:
Function:
Catalytic subunit of the ethanolamine phosphate transferase 2 complex that transfers an ethanolamine phosphate (EtNP) from a phosphatidylethanolamine (PE) to the 6-OH position of the second alpha-1,6-linked mannose of a 6-PEtn-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-2-PEtn-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol (also termed H7) intermediate to generate a 6-PEtn-alpha-D-Man-(1->2)-6-PEtn-alpha-D-Man-(1->6)-2-PEtn-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol (also termed H8) and participates in the eleventh step of the glycosylphosphatidylinositol-anchor biosynthesis.
Miscellaneous:
MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRLGSGTFATCCVAIEVLGIAVFLRGFFPAPVRSSARAEHGAEPPAPEPSAGASSNWTTLPPPLFSKVVIVLIDALRDDFVFGSKGVKFMPYTTYLVEKGASHSFVAEAKPPTVTMPRIKALMTGSLPGFVDVIRNLNSPALLEDSVIRQAKAAGKRIVFYGDETWVKLFPKHFVEYDGTTSFFVSDYTEVDNNVTRHLDKVLKRGDWDILILHYLGLDHIGHISGPNSPLIGQKLSEMDSVLMKIHTSLQSKERETPLPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFERKPGDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLLFPVVEGRPMREQLRFLHLNTVQLSKLLQENVPSYEKDPGFEQFKMSERLHGNWIRLYLEEKHSEVLFNLGSKVLRQYLDALKTLSLSLSAQVAQYDIYSMMVGTVVVLEVLTLLLLSVPQALRRKAELEVPLSSPGFSLLFYLVILVLSAVHVIVCTSAESSCYFCGLSWLAAGGVMVLASALLCVIVSVLTNVLVGGNTPRKNPMHPSSRWSELDLLILLGTAGHVLSLGASSFVEEEHQTWYFLVNTLCLALSQETYRNYFLGDDGEPPCGLCVEQGHDGATAAWQDGPGCDVLERDKGHGSPSTSEVLRGREKWMVLASPWLILACCRLLRSLNQTGVQWAHRPDLGHWLTSSDHKAELSVLAALSLLVVFVLVQRGCSPVSKAALALGLLGVYCYRAAIGSVRFPWRPDSKDISKGIIEARFVYVFVLGILFTGTKDLLKSQVIAADFKLKTVGLWEIYSGLVLLAALLFRPHNLPVLAFSLLIQTLMTKFIWKPLRHDAAEITVMHYWFGQAFFYFQGNSNNIATVDISAGFVGLDTYVEIPAVLLTAFGTYAGPVLWASHLVHFLSSETRSGSALSHACFCYALICSIPVFTYIVLVTSLRYHLFIWSVFSPKLLYEGMHLLITAAVCVFFTAMDQTRLTQS
The following text describes a protein:
Function:
Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos (By similarity). Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes. In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPKVFLVKRRSLGVSVRSWDELPDEKRADTYIPVGLGRLLHDPPEDCRSDGGSSSGSGSSSAGEPGGAESSSSPHAPESETPEPGDAEGPDGHLATKQRPVARSKIKFTTGTCSDSVVHSCDLCGKGFRLQRMLNRHLKCHNQVKRHLCTFCGKGFNDTFDLKRHVRTHTGIRPYKCNVCNKAFTQRCSLESHLKKIHGVQQQYAYKQRRDKLYVCEDCGYTGPTQEDLYLHVNSAHPGSSFLKKTSKKLAALLQGKLTSAHQENTSLSEEEERK
The following text describes a protein:
Function:
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.
Sequence:
MSHYQNKGDRSEGQLKKTGRSSGPGHQRSGVPPSAVKGGGAGGPSPSGSAPPAPAASLGGVQPPAGAPPARPTTPASSTNRGGKRANGPAGASRSTASAAPVDYGGSYKGPQYAGPPFPNQQPQPPQQAVVRQGLGPTDVNQHPATNAGQQSEIRQITPRASLPGTGGAPPSIPRQHVVGSNMAPGAAARPPPPSLSAATVVGTDPVSPVATSASSAVDMSRVTLQSSFSFQFGSITPGFPLTGLQAMQIPARTSSAPPNLDEQKRDQARFELNRGNAANKVPTVPTGPPPGQVARGAGSANEPPASLQQSLSAQGSPVGGTSGVQSQQQQVSHPPGLAQQPVQYSQGQGHPVSHQGHQISQAASQQLHIQMAAQVQVHAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAHQAQQAHAQQQVLAQQTLPQQSLPQQAMVQQSLSQGMKYPQPMMAPPHGAQMISQQMGNPMAGQLSGQQVPPQMAHQLGPQMGGAMGQQLPPGITGAQYGPPASSQFIQPQRSRAVKIVDPHTHEEVRFDGKSKKGDSFMDSGPPTTGSVSAGLPVRVTSNGPPQTRAPVNYGSAPHHTMVPNMYNFPMPSGYAGPPYGFQSVPPPKSAVSAAGPPTNTSSVRYSYGVPTPPTYHPGAVPSSAGTKVVPPAGLGITVTTSEMSTATPPASLVASPVGGPPPPPPTAASTGTSAPVVSARVVPPQAQLGGNPAPSSNGRATALVSGPAVGNVPVPVTPIAIGSLGFKFGDVDESGSTIAVPGAESSPENVSSAPVQVSSTNGSTPAGEDTSSTTPTVPGSEGSSWRKDSGSRNSTPATTPKPTVSLPSSKSGSVPSSSNLSSPKVASGPSSTPSVDKTKPENPKPAITRENSRKKKEKAQRNQQQQQQVLTSTPPVVDSDGERKGDAPINASTTAGQTPGASEKVTAASPKVALQRSYSGVQSNPGTAGKTSSSGKSEDAKLTSKLAADSEKRASGKPSVLATANSESNSSVQVMVVSEGDDGSRKLTPKQGSGKSLTSSKSLEGKDSLNADASTTGKNSSVSKLSSSSSKTLSVTTAVKEVPSGHGGESSPKKGLGGKASQSNEAIKEAATLDSLGSSTSTPELPASQQDEDTPVCAPSQVDSEVPVETVAKLPEVVNGVEDVTVDARSPCTEGLKDVKRPADGTQGDQTVSIDKEAGKKSHVNGTSVVEAKAVSESDGPADLTSTSAKEISTTSADDSVVDGTPDEPVAPLSETVSKEKDLLTEAKPTADVAETDAPPSSHLHSAESDIESVLGNENISLVQAIAKEKEAVEHIADVLVSNPTNSTPGQESTRAKSAASVGNSESSVSAEPKRPKYKPDITVNVDNLVEPSDSFLPNHPSGDQGSVSSVEKTQDGHHNSDNSGFVVEDYVSRDGSEVQNASVASSAELESSSSVAPELKPSGSKKKKKKEIYAKADAQGPTADLFTAYKAPEEKKLDDQVKRSEVVGSSNAGGDSKKDSSSTFEKPTVLKELDDWEDAAELPTPKITSGVPSISSDAKVASVDSPSPGNFGIKKYTRDFLITQQNLNRDLPLEFEIRVDLSELFLNRDSHPSGDTLPSPGRYERQASGAGARLDRRNSNVGAEEDRWTRQPGSVQSPGRVPPDGSMGMAGPPGGFRPGGQSRNAGLMGMPPGMRPGGMVSQGGIMPMGSGGLLPNNPLITAQQQHMVQMHPNSGPGRPMNPGGAGGGVDADRWQRAPVAQKGLIPSPRTPLPAIHKTENRYQVGKVSDEEQGKQRLMKGILNKLTPQNFDKLFAQVKEVHIDSATTLTGVISQIFDKALTEPTFCEMYAKFCVQLAVELPEFTEDEEKITFKRVLLNKCQEEFERGEREQQEAEKVEEEGEVKLTAEEREEMRTKARRRMLGNIRFIGELYKKNMLTERIMHECIKKLLGEYQNPDEEDVEALCKLMSTIGRIIDHQKAKEHIDAYFKRMEMLTENNKLSSRLKFMLKDVIDLRRNIWQERRKVEGPKKIDELHRDAVQERQAAAASGRDRLQQRGGGMPAGGGRRPGNDFAMRGPQPQMYSQGNQMVGNMPMSGIRGAQPQPIRGSFGQDVRTEDRLLMDRPPVPMPLSQRPSDEGIKLGPQGGLGRGMGSRGAPLVSGRSALADVPQMPFGENRRPGMGHMSGFGTGMISERGLYGGRDDSMLMRGPGFDRPLAGADRPLLDSPLGQERLAPTSGRDMRASDRPLERPRTPYGATSSMRPMTPPTPVRHAPAATLALSEDELKKKSLSTIAEYYSVRDLKEAAVCVDELKTPKFHPTMISMWLSDALEKKDVERELVMKLIIHLRNTDPALLTSEHILRGFEQVLSSLEDLAVDVPKAPEYVAGMFSKLIVAGIFSLPQVGKLLKDCMSEAGGGSLLQSGHAFSMFGSVLDTFRREKGEEDMIAMYRNSGLHLEDFLSSEHKRGGGYFESFLEKKNLQCLYPMIPVENYLRDAMDKDEPVADILKWLEKNVPQSTRTEASFLRLIMRQVLRRSVPVENNKIAPQFEITLEGKVKKYASLLKGFATGKAKTAEANQRQYIVAVQLFADDLGHPPGLVTALFSDLYREEVISERAFLQWQDDVNDSTPGRAKAIKDTFKWFRWLEEAPEDGGDEED
The following text describes a protein:
Function:
Confers resistance to norfloxacin and enoxacin.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCLLSGLGGTLFDPPRSALVVKLIRPQQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAVLFVLCAAFNAWLLPAWKLSTVRTPVREGMTRVMRDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDVAGAPSAVKWMYAIEACLSLTLLYPIARWSEKHFRLEHRLMAGLLIMSLSMMPVGMVSGLQQLFTLICLFYIGSIIAEPARETLSASLADARARGSYMGFSRLGLAIGGAIGYIGGGWLFDLGKSAHQPELPWMMLGIIGIFTFLALGWQFSQKRAARRLLERDA
The following text describes a protein:
Function:
Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase.
Sequence:
MDCGPPATLQPHLAGPPGTARRPVAVCQQESLSFVELPPSRLCVDLFPIAPEELQAPGSRWSLATPAPLQGLLWPTSPGGPDTHIASTSGGMRPGRAGSWPHCPGAQPPTLVEPWSSQHMQPQRRASHSGSEKSAWRKMQVYHNEEATGTETPTGLLETGQAAQEQALCALEPGPQELSGNARGGLEAPERRRFSASELMTRLHSSLRLGRSTATRVLTSGSGAGAIREGKLPVRESRRAETRADSVSLPGPVDLNEVHGGLVEPRLDTQDKPTQDPSSATERRQSRFLLNSVLYQEYSDVASARELRRQQREEEGPGDGAEGAEEGPGPPRANLSPSSSFRAQRSTRGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSVELSECLGTQDKQWLFSKLPEVKSTSERFLHDLEQRLEADVLRFSVCDVVLHHCPAFRRVYLPYVTNQAYQERTYQRLLLENPKFPGILARLEESPVCQRLPLTSFLILPFQRVTRLKMLVENILKRTAPGSQDEDMATKAFSALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHANMAELQVRDLSLKLQGIPGHVFLLRLLHGQRARHQLLLRARTESEKQRWISALRPSSPQEDKEITCDGEDRPQVQCVRTYKALQPDELTLEKTDILAVKTRTSDGWLEGVRLADGEKGWVPQAHVVEISSLSARLRNLREYKRVSNASSKLGDPPA
The following text describes a protein:
Function:
Required for biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MASIFQQASKAAKGKRKADAHDEDAVAAPIRRNKQRVLMLPSRGVTSRMRHLINDLESLMPHAKKDSKLDSKSQLHLLNELAELNNCNNALYFEARKREDLYMWASKTPNGPSAKFQVQNIHTMDELKMTGNCLKGSRPILSFDKEFDEKPHWTLVKEMFTQMFGVPKGARKAKPFVDHVISFSIVDNKIWFRNYQIVESDPGATAMAKVEEAQDGKKKAGGAKDASRQPKLVEIGPRMVLSPIRVFEGSFGGATVFENPEYISPNAIRHMVRKQKGNKYADRVNQQESFRTKKDRLKPREDALSRNKVFA
The following text describes a protein:
Function:
Aspartic protease which plays a role in heme homeostasis and mediates inter-organ signaling between the intestine and extra-intestinal tissues when cellular heme levels are low.
Subcellular Localization:
Secreted.
Sequence:
MKTFIALLALLTVVSAEVHQFNIGYRPNMRQRMNAKGKLAEYEKERNELLSKKSLQLASSSSPVIDYEDMAYMVQISLGSPAQNFVLFIDSGSSNLWVPDITCAGGKDATCGSYCKSTPYDACLTFCQEECCTKTVEGVKVLSTTDACQSKHRFNSSLSSSYVTNGQKFDMTYNTGEVKGFFGVDTFCFTNTSVCATGQVFGQATTIGEAFAKQPEDGIIGLGWPALAVNQQTPPLFNLMNQGKLDQPYFVVYLANIGPTSQINGGAFTVGGLDTTHCSSNVDWVPLSTQTFWQFKLGGVSSGSYSQAPNSGWQAAADTAASFIGAPKSVVTSLAKAVGATYVPLTGAFFMDCDAVVPDIVFTINGKTYNMPSTSFVVSAGPGPCMFAFYELTAGGFYPAWMLGPPFMRAYCHVHDMKSGRLGLAKVL
The following text describes a protein:
Function:
May be involved in fatty acid metabolism.
Sequence:
MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLRSQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVVTLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAFTRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFSPAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAWPHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGKIFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEIERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWVFADSLPETSSGKIARSRVKKWLEESVQYK
The following text describes a protein:
Function:
Putative oxidoreductase.
Sequence:
MVGKILDFECAVITGGAGGLGYAMAEYFLSQNKKVILVGRTESKLVQASKKLSNAPYYVLDTGNVHEFPAFTQKLLCEHPEVDCLINNAGVQRPLEVQNLALDKVDNEININIRGPVHLATAFLDHLKSKKLGVIMNVSSVLGFVPYSIINPNYNGTKAYIHFWSEAQRIQLKHTNVRVVEIVPPSVGTDLHRERENPDDNKKHLGAINSLTVQEFMDDLVKGLKADQDVISAGSGIALVNKWDNAFREQFQSAAEKYQPK
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Miscellaneous:
MISCELLANEOUS: Present with 3400 molecules/cell in log phase SD medium.
Sequence:
MDRFQIGDEQLLRFYQLKTINPTHSWAQDSSKLNNEEATSNELGVETSFDILKDFKYGNQISIDKESRAYLNDESLSYIRDPLNGQEMSKELQHLPNDSMRLNYLVNSKQFNVKAFLRDMHKQDSFNDLNNSLDRLDSDIQDQSIHLKQLVGKNFTKYVKIKNKLDQIYKEFDEKTNEKNQCDSPKENQINVESLNKKVDEVIRTTTFKLKPLMDNYQKILNYQATKKFIELNKFYFNLPKSLKRCLTNNDFNEFIIEYSKGLTLRRRFNQSSDASQSLVIKRIWTQIENLLVTYKDLIWNSLINSNFNIDQPQETILSLFSKLLNLENFINNNQRESESGNKNTTSSSNENPILRWMSIKMNGFQNELNELSGHMISKIIHSQRLILQNNTNQDKSQGCVELSYYLKINQLFQIISDTGKDSEGLKSTVEPNKVNTISGTSYLNLNCQPSSQGLTDSPTIIEMWLLILKYINDLWKICDQFIEFWEHIEKFLDGTYQNSIINEKRKENILIGDSNIIESYQKSLILKEEQINEVRLKGEEFITSVSQNLISFFTSSQSSLPSSLKDSTGDITRSNKDSGSPLDYGFIPPNCNGLSCLRYLPKIVEPILKFSTELAQLNITTNGITICRNTLSTIINRCVGAISSTKLRDISNFYQLENWQVYETVTFSSKSQDSSKNLTFEYGVTQFPEIVTSFQEVSIKTTRDLLFAYEKLPIINGISVVSYPSKQLLTGIEIQQIISMEAVLEAILKNAAKDKDNPRNSHTILTLTNLQYFRECAFPNILQYFDDAFEWNLASKNLELFSLLSKMESSIFGNYLSDLKINLRDTLEEKFHEINWPMYTSNSFRVGDYIIEALMILIVVHSECFRIGPQLIHKILIETQIFIARYLFEAFKPYVGNLSNDGSLQIIVDLEFFQKVMGPLLEKDTEATLRACLQNCFQNDTNRLQKCINEINPIVSANLKRTAIQFAAFS
The following text describes a protein:
Function:
May be a transcription factor with important functions in eye and nasal development.
Subcellular Localization:
Nucleus.
Sequence:
MPQKEYHNQATWESGVASMMQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVAKIAQYKRECPSIFAWEIRDRLLSEGICTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGTWGTRPGWYPGTSVPGQPNQDGCQQQDGAGENTNSISSNGEDSEETQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQANNSSSHIPISSSFSTSVYQAIPQPTTPVSFTSGSMLGRPDSALTNTYSALPPMPSFTMANNLPMQPSQTSSYSCMLPTSPPVNGRSYETYTPPHMQAHMNSQSMTTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWSRLQ
The following text describes a protein:
Function:
Catalyzes RNA cleavage releasing a product with a 2',3'-cyclic phosphate at the 3'-end.
Subcellular Localization:
Secreted.
Sequence:
MCSVLIFISILTVLAQCQKIPRFDVSNSELLAMAQKLRQVDTNRARPDQIKLNYQGHTVTRDDSDAAQAKLFSKVDTSLFRKPSYELYINLMDNFNRQTGVIEPRVSQAEEKNEVGKFLDYVLESRPMQELYNWFKAKGHPIATSPQVFRFWIGQLWFSHYSRALGRPDTSGFEHVFIGEAKNGEISGMHNWVRFYVLENNRTENFDYKGFTVKRFNIMAALKFTWDGLLKRAGSILIGTSPEFDMALYTMCFLSRRGRETCDVEFDGCPLQITSFEIMQQNKVYIGSIYPTAGRITDQCRAQNRFN
The following text describes a protein:
Function:
Plays a role as an effector of the ADP-ribosylation factor-like protein 2, ARL2.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Nucleus. Mitochondrion intermembrane space.
Sequence:
MASSSEDVESIDPSFIIFDQCIGCIEEIIMSEEFLKTQHHFLTKHCTVFDDMEENKLIYMDIFQDYAQLVETFLEQKLREMFPLFSMEEFVKELKSQPVQLEGEIFDILREFTDFLSFKAMMLDYKTGQNSDVLLLSGFKILK
The following text describes a protein:
Function:
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
Sequence:
MVFDLLERLFNRNKTGSATVAKDRLKMVLAVDRTEIAPQTIEQIRKEILDVIVRYFEIDENEKFDVTLERERGSTAIIANVPIRRIRPEHI
The following text describes a protein:
Function:
Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience.
Subcellular Localization:
Nucleus.
Sequence:
MYRSTKGASKARRDQINAEIRNLKDLLPISDADKSRLSYLHIMSLACMYTRKSVFFSQDITTASSAEETTGFLSFYELNELIQGMPGFLLLLTGEGKLLYLSDSVSDHLGHSMVDLVAQGDSVYDIIDTADHFIMRSNLVPPTSPDTDRLFRCRFNTSKSVRRQSAGNKLVLIRARCLSQTPSESSPGSYWTSNPVWVCFCAPLEPHTSRGGTASDRESTSASALESSFFLPCFRSQHSRDMRLHEAQESVSVYLGLNVEILRSQSWYSFLHPQDLSHASAQHCSLLREGGEGRAEMVVRVETADHSWVWLYMVLQLETGETPIVSNNYIISETEAWSVRQQLSSEQTQLSLVLGSSTSQQESVSLQSPETLSSPDQVFTPGSSGLSGQSFDFSTAACSTGSTEEQGGSSSMEPAQVESGPRSSLSSMEEETFFQHEPSEPMASPSSASSPIPVTVATVSDLDFLTQNILLPPAFQIDPPLPVLPLPLPPVPTSQAQQTKEFVCTPPYTPQLGGSNFPFGEPHFSFDPTGATSPPPLGQTATVTTTTAPSLSPSAPSNPQSSPPPPTTTLSSLLPLTITSPTTEILFPVEPCSGSLYEKLPPTPDSPGDGDCTVMTLPEVRGPLYVDVPHGPLPYPPEGLLTPEASPGKQPSLPFFSSLRDREKERTEISLLAQHISTLAEGFYLDPLLAKLVPSTLSEHSQSPDSDGLDSIPLLGEFYPLKSWKGLDLPIFQDDESLFEESVLETLLQDLSSSPPLSPTPSSSSHSSPPSSPSTPECWCPSLHFDGVSAVSAGHFCSVQSAHCNNEAGRGAMMSPVNAGNMTDTKAAGEVPMETDVASSPLFTGIPTSPPLQLTASPASPILMPVSSPVSPPSPGLPCAQSLLEELAALEPMFGAGASIAPGLGQQPELYQLQSHVPQQCFRKDGSGSDPPF
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MFDNDSNKYNNKVINIYLINNNDALVWNTDDIYQIRKSFRLVGSLLGSVENFKNLSTINSVPLLLSPCEVRLGLENGWFRLINEACDYPTVSTDELNSFNNAREEIYKLQIDRYLDTKILKEKEFRIKYSSQNLNKKNKSNKKNINESDINSNDNGTNNSNNSNNIKNDTNINNDIDNINANNNNINNINNKLELNEEDLKKKLVEKEKILNNFKSFNNDIFIYTSTEEAIENEPTSRVWRDKRNSEDELKYTVFKDLWNRGYYISGGSKFGGTFLVYKGDPFLYHATFIVVLKHYTQEFKALDLLTSSRLAVHVNKTTLFASIDNKSKQPHYISINWRGVT
The following text describes a protein:
Function:
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Sequence:
MADNNKKPAGLTEKKANRRGAARLAAVQALYQMDIAGAGINDIFAEFESHWLGNEVEGDTYLPAEAAFFRDVVSGVVRDQKKLDPLIDEALSKGWPLKRIEAILRAVLRAGAYELQHRKDVPGRVVVSEYVDVANAFVDREETGMVNAVLDQIGRQFRGDEFGRG
The following text describes a protein:
Function:
Endoribonuclease that cleaves single-stranded RNAs at 5' of uridylates and releases a product with a 2',3'-cyclic phosphate at the 3'-end.
Subcellular Localization:
Secreted.
Sequence:
MVYLVFLCLLPSLISGASILPEPRKDVRASATDAEIQSLAEQFYAADTNKAASGDITLNLQYKASSSQTSTGTDYANQKLFRYVNEAKLFARPTFARLVNLLDNYAQKTGSAESVPTTEVNEQNAFLDEIFKTSIITKLSNFFISKGYYSSAASFKTDLKAMWFGLYTRTSGPLDSSGFEHVFHGEIHKGKVSGLHNWVKLYLLEKSGQVNYLSYSADGVWKGYPDIYAFQLKWSTYLKTIGSFFVGSSPEFDIAMYTLCYVTRPDSLCSVKMGGSIFKIQTYTWANSTYGNGKRFVASSYPI
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MKQLSVQEEATKPLCGNVSSAEPLQVLLKPLNTTTQMATQELDCTDIKHSYSVQGIGSCKMDRPLTESDNIQSQDKTDTRDPDLKLDVRQDHNRLGWQGLDLRHTSGNLDLHKAPINEIRDSENTQQITEQSPGNTGIQELATSETPKGMKNPISSQEDLKQNPGDMGTLELAIIQTLHNIGHAMSSSEQTVKQSPVSMEITVNLPEDIDTNSQAVSQCTLYTHNTDVTQSQDIDSQTISHSADNMDSQELNIKAVSIAAQVLNMNSKTPNSMVQSRNPNYADTQDPNKRRTLESKCIIDTFSAQSSNNAVVQETGMIQSSDHIYIQDMVARHSSNIMASPDKDIIYHSYPEKISSAPIPSIPCSVSDASNVYQSLLSEGSSSILVQSDRPATAFSTGSVDGIINAPINPQIIQGCIVANPEGSNSEITQYLILQEQDSTSSVTVASVPVGERYQTHGSSCAAESMADAESLEGMVEVVFVQQYKCKMCKYKSTSKPTLLRHVRERHIQPTSIEEKRSHEGKVARSKEEEEEEEDDDDIVDAGAIDDPNDDSDYSPGEDTPNNNLESAHGILIKERPRRKPGRPRKIPRIDGPKLDIPLSSNDNQTDQGVTNSDLENKDPASLAISEEQSPPKRMRGRPPKHIRGKKYRRFRGSRFYRPPSKRLLRPFICRICGSSFLTHDDFTFHVTSHVGNDPQAFQCQQCSYQCRRWSSLKEHMYNHKGSKPYKCEECEYTSVYKKDVVRHSAVHREDRKKKSEKTSKPASYPCPVCGRIYTMQKRLTQHMKIHSAEKPHMCDKCGKAFKKRYTFKMHLLTHLQCVGKSRYKCEFCEYICGDRKQLLNHQLTHMNDKPFKCSQCKYHTYRQDFLLSHMATKHAGGKPFACDHCHFTTKHKKNLRLHVQSRHPLLYNEWSQRHPEETPSRRRPFFSMQQIEELKQLHEQSENQGPSPQEVVMDAAELSYQILQPTSQSPTEEQSHGALGAAAIIYEQEGEEEEYATRAALDLLLNMSTRREGTGGPLQVAVVKSGSGGEVQSSQSMAHEPHMAQVLTLHVEGNGVTSVQEAGYEDAGVEDTGYEGAVQQITIDNAFTTAEYSLINTENIPASLCSETSASPGSTLLGENIKDKILRKSQQAEHVSDHSAAPAAKKFCCKLCGTTFLGRSEMEIHKRAHVPSGGFKCPDCIFTAANWPEVRNHLSVHSDRRPHRCDQCSFACKNKRDLSRHSMIHTNQRPHSCPICGQRFTRKAHLKFHIQRLHRGKNNEPQENEAELTPAPSLEEEHIFLTQEESMASQEDTAYIQEITTADGQTLQQLVTADNQVQYIISQEDIPHLIPQEYVVLPDGHHIQVQDGQITHIQYESGTPFLQDPQIHFVPMSPSQQLLTQEQLQAAAHSAVTAVADAAMAQTVFSTETEQPLPQEIEYDIITLGE