lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTISYSGNVIRLLLRWKGSIWRTVWRELLIYLFFFYSIRLFYLKGIDFIDDDDDDRNKIRRMFESFCRQCDSYTRLIPLTFLLGFYVSNVVARWWRQFETLYWPEDILSVLCTVLHQHDDKSKRRRHTIARYLNLSNALAWRDISSKIRLRFPTVHSLIEGGLLTEKEYQILETMHTENESSRWMTPLHWIQQIMRQVEDETKPTASLLNQFVAELRIFRQSLRKLYSYDWVCVPLVYTQVAALATYSFFFFSLFGRQPLLPEIESGKEIDLKVPIFTIVQFLFFVGWFKVGQDLMRPFGLDDDDIELNYILDRNVRISFAIVNHLQEAPIPDFENDDDKMWEEMHPPVKDGETSPSLRIPQLPHSKYSSQLSEHPPRLHAYVPIDDDRTSIKDMESHHGCISVKKDKKHLNW
The following text describes a protein:
Function:
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MPSLLVLTFSPCVLLGWALLAGGTGGGGVGGGGGGAGIGGGRQEREALPPQKIEVLVLLPQDDSYLFSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSIYSFDETKDLDLEDIVRNIQASERVVIMCASSDTIRSIMLAAHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNMEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGRFEMRPNVKYPWGPLKLRIDENRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNQQEESNLGKHRELREDSIRSHFSVA
The following text describes a protein:
Function:
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNTLLLSINWNPNPELFNLFGISIRYYGLLWAVGIFFAYIIVHYQFRDKKIDEKKFDPLFFYCFFGILIGARLGHCLFYDPGQYLTSGKGFVEMLLPIKFLAGGGWKFTGYEGLASHGGTLGLMIALWLYCRKTKLHYMDVVDMIAVATPITACFIRLANLMNSEIIGNPTNVPWAFVFERVDMLPRHPGQLYEAIAYLILFFIMIYLYKNYSKKLHRGFFFGLCLAYIFTFRFFIEFVKQNQEAFEDNMMFNMGQWLSVPFIIIGFYFMFFYDRKKVAKK
The following text describes a protein:
Function:
Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator.
Subcellular Localization:
Nucleus.
Sequence:
MTPTITGSISSRETLLTNKLRKPMVEKIRRERINSSIEKLKTLLAQEFVKQQPDSRQEKADILEMTLDFLRRSQKSSAAGDGRSRCVQEAVSFLSQCPVQTQSHTRLMKLFLHMQTPADQHTRVDNPQTTEKHANSSAKQHTPARSHIWRPW
The following text describes a protein:
Function:
Involved in chloroplast RNA processing. Can bind RNA. Involved in chloroplast development. Involved in chloroplast ribosomal RNA (rRNA) processing and/or translation. Required for FtsH-mediated chloroplast biogenesis. Involved in translation and accumulation of chloroplast ATP synthase subunits.
Subcellular Localization:
Plastid, chloroplast. Note=Accumulates in discrete foci within the chloroplast.
Sequence:
MSFHHLCSSPSSLLHDPLPLCNLLSVYPKSTPRSFLSSYNPNSSHFHSRNLLQATHVSVQEAIPQSEKSKLVDVDLPIPEPTASKSYVWVNPKSPRASQLRRKSYDSRYSSLIKLAESLDACKPNEADVCDVITGFGGKLFEQDAVVTLNNMTNPETAPLVLNNLLETMKPSREVILYNVTMKVFRKSKDLEKSEKLFDEMLERGIKPDNATFTTIISCARQNGVPKRAVEWFEKMSSFGCEPDNVTMAAMIDAYGRAGNVDMALSLYDRARTEKWRIDAVTFSTLIRIYGVSGNYDGCLNIYEEMKALGVKPNLVIYNRLIDSMGRAKRPWQAKIIYKDLITNGFTPNWSTYAALVRAYGRARYGDDALAIYREMKEKGLSLTVILYNTLLSMCADNRYVDEAFEIFQDMKNCETCDPDSWTFSSLITVYACSGRVSEAEAALLQMREAGFEPTLFVLTSVIQCYGKAKQVDDVVRTFDQVLELGITPDDRFCGCLLNVMTQTPSEEIGKLIGCVEKAKPKLGQVVKMLVEEQNCEEGVFKKEASELIDSIGSDVKKAYLNCLIDLCVNLNKLERACEILQLGLEYDIYTGLQSKSATQWSLHLKSLSLGAALTALHVWMNDLSEAALESGEEFPPLLGINTGHGKHKYSDKGLAAVFESHLKELNAPFHEAPDKVGWFLTTSVAAKAWLESRRSAGGVSA
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.
Miscellaneous:
MISCELLANEOUS: Present with 1380 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MPAVLRTRSKESSIEQKPASRTRTRSRRGKRGRDDDDDDDDEESDDAYDEVGNDYDEYASRAKLATNRPFEIVAGLPASVELPNYNSSLTHPQSIKNSGVLYDSLVSSRRTWVQGEMFELYWRRPKKIVSESTPAATESPTSGTIPLIRDKMQKMCDCVMSGGPHTFKVRLFILKNDKIEQKWQDEQELKKKEKELKRKNDAEAKRLRMEERKRQQMQKKIAKEQKLQLQKENKAKQKLEQEALKLKRKEEMKKLKEQNKNKQGSPSSSMHDPRMIMNLNLMAQEDPKLNTLMETVAKGLANNSQLEEFKKFIEIAKKRSLEENPVNKRPSVTTTRPAPPSKAKDVAEDHRLNSITLVKSSKTAATEPEPKKADDENAEKQQSKEAKTTAESTQVDVKKEEEDVKEKGVKSEDTQKKEDNQVVPKRKRRKNAIKEDKDMQLTAFQQKYVQGAEIILEYLEFTHSRYYLPKKSVVEFLEDTDEIIISWIVIHNSKEIEKFKTKKIKAKLKADQKLNKEDAKPGSDVEKEVSFNPLFEADCPTPLYTPMTMKLSGIHKRFNQIIRNSVSPMEEVVKEMEKILQIGTRLSGYNLWYQLDGYDDEALSESLRFELNEWEHAMRSRRHKR
The following text describes a protein:
Function:
DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.
Sequence:
MSLTSLLNPKSLEDFLGQEHLVGKDAPLFKALQSKHFPHAFFYGPPGVGKTSLAQIIAYMLERPILLFNATDFKLEDLRLKLKNYQNTLLKPVVFIDETHRLNKTQQEFLLPIMEKDHALILGASTQDPNYSLSHAIRSRSFIFELTPLNKSDLDRLCAKALTLLKKQIEPGAKTYLLNNSAGDARALLNLLDLSAKIEDPITLKTLQSLRPHSLNDGSYSDDTHYNLTSALIKSLRGSDENASIYYLARLIAGGENPEFIARRLVIFASEDIGNANPNALNLAASCLFAVKQIGYPEARIILSQCVIYLACSPKSNTAYRAINQALDCVQKGSLYPIPKHLLPNAKDYLYPHDYNGYVKQDYLEKPLDLVSSQGIGFEKTLLEWLDKIRN
The following text describes a protein:
Function:
Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGKVWKQQMYPQYATYYYPQYLQAKQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKATNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRVLRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWPREGEAGMTLTYDPTTAALHNGFYPSPYSIATNRMITQTSLTPYIASPVSAYQVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYTHMQTATVPVEEASGQQQVTVETSNDHSPYTFPPNK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Plastid, apicoplast.
Sequence:
MAVKIEAPYFTNDFVKTEQLSDNDKNPNEQITEDDSWVVIGSFFGSHGLVNQQIESYNDFIEYRMQEIIDEHPKIEIRPQPQYRTDRDENDNIIYSLKFGQLSLDRPFYDEKNLSNKNLWPQEARLRNLTYSSAIYIDIEQSTYIIDEVTKKPVLKEKFIYERINLGRIPLMLKSMFCWTKGLPENEIADMGECSYDQGGYFIVNGGEKVLVAQERMANNFIYVFKKKQPSKFGWVAEIRSQMERSQATSGFSVKMKTRSGGSQYGSNKSGGQLVATLPYIRTEISVGILFRALGCTSDRDILQRIVYDFNDKLMINALRETLEECIEYPTQDVCLDFIGKRGPTVGASREKRILYAKELLRKEVLPHMGTHPGVESKKSYFIGYMINRLLLAELGRIKEDDRDHFGKKRLDIAGPLMASSFSTYFRKMAKDVRRVLQRQIDNNKPFDVAGAIRSCSQITQGMQYQLATGNWGKDKDGKVIRTGVAQVLNRLTYSSCLSHLRRLNTPLGREGKMAKPRQLHNTHWGMICPFETPEGQSVGLVKNLSLMCDISVGTSTNNIYEFLTEWGLESLDEVPPELMKEKVKLFLNGKWVGCFNQIDNLIETLYELRRRCDISPEASIVRDVNSKEIKIFTDSGRAMRPLYVVKNVNGENKLKLTKEHVNNIEKYPETYNWDYLIQEGIIEYIDCEEEETTMISMFIDDLKTGTGYYNNFTHCEIHPSLILGVCASIIPFSDHNQSPRNTYQSAMGKQAMGIYVTNFNIRLDTLAHLLYYPQKPLVCTKVMEYLRFRELPAGINAIVAIMCYTGYNQEDSLIMNQSSIDRGLFRSVFYRTYTSEEKQQGSLIIESFEKPSVRVVKNLKRGDYTKLDDDGLIAPGIRVLGDDIIIGKVSPNIDDEDDIIIEKRNTSSSSIQIYNKDSISNNNSNNSNNNMNNMSNMSNMSNIRSSISSNLSFSSNIGSSNVLDTLPDSPINNTYNNNNNININSSSNNYSLHGAASVTSSTPSSTTIFSSGQTAGSSNSNTKYGTTIVSSTKDDTEIPTLTISSTNVLKQYKKDCSLSLRSNENGVIDTVMLSSNSRGNKFAKVKVRSVRIPQIGDKFASRHGQKGTIGITYRTEDMPFSSLGIFPDIIMNPHAVPSRMTIGHLVECLTGKVAAIEGGEGDATPFSKITVQEISQKLHNLGYEKYGNEMLYNGHNGRMLKSKIFIGPTYYQRLKHMVEDKIHARSRGPLTMITRQPTEGRSRDGGLRFGEMERDCMISHGSAKMLKERLFEESDAYRVHVCDNCGLCCIADINKNAYECTVCNSKTNISQIYLPYACKLLFQELMTMAIYPKLVLEDV
The following text describes a protein:
Function:
Involved in poly(A)+ RNA transport. Involved in nephrogenesis.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.
Sequence:
MFPGVSSPRTPGPGTRRGPLVGIGPSTTPRASRRGLSLGSAVSSPVLFSPVGRRSSVSSRGTPTRIFPYHSISESVNYDVRVFGSSLPVKIMEALAMAEEDQRSLHEHPGWNVKGLLSVFALQLSVCKDLQLPPSDFHWSADLVALSYAATSGEVHSVQAVSVMVATKEGSIRYWPSLAREDTYSDTSVDLGGEKVCRFLTAVQGGSFILSSVGSQLVRLIPEGSGKIHQHVLPQGQGMLSGIGRRVSSLFGILSPTSDLMLASVLWDRGNSSFYTLTSSNISKWELDDSSEKQVYSWDMHRALKESITDAIWGSESNYEAIKEGVSIQYLDLKQNCDGLLILAAAWHLGDSPCLVYYSVITVEDNGNQMSDAVTVEVTQYNPPFQSEDLVACRLMVPDFPSQMTYLYMESAVFVCSTGTGKVSLPQEKIVFDTQGDGILGAGSCGGVPILFSRNSGLVSVTPRESMSLLAEGLEESLASSGGGRGSESMVFETTKNDTAAHEDKTKLLKTAFLQYCRKDLGRAQMMADELFSSHTDLESDPELDKAVTQISVDLIDDYPASDPRWAESVPQEAPGLSNTSLIVLHQLEDKMKAHCLLVDFLHQVGLFRRLDSYPIRGTPMTTRLLLCEHAEKLSAAITLKNHHSRLPDLVNAAILLALNKRECEVPPSLTPADVFFREVSQVDTICECLLEHEEQVLRDVALVSQEWAEVAIDVNTVLKDMLQAAAHYRLNKGSMYSREEPLGKEPEYVPWTATSGPSGIRTVIMRQHGIILKTVYPQADSNLRSIVMEQLVALIDCFLDSYVSQLKSLEKSSDQERYSSLEVEYLQKRSELLSPLLTLGQYPWAASLAEKYCDFDILVQMCEQTDNQARLQRYMTQFADQNFSDFLFRWYLEKGKRGKLLSQPISQHGQLANFLQAHEHLSWLHEINSQELEKAHTTLLGLANMETRYFAKKKTLLGLSKLAALASDLSEDTLQEKIEAMAEQERFLLHQETLPEQLLTERQLSLSAMPVLTAPQLISLYICEENRRANEYDFKKALDLLEYIDEEEDVNIDDLKLEILCRALQRDDWSGSDGRDDPIEVSKDSVFVKILQKLIKDGVQLSEYLPEVKDLLQAEQLGSLKSNSYFEFVLKANYEYYVQGQM
The following text describes a protein:
Function:
Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.
Sequence:
MGLNTAIATRVNGTPPPEVPIAGIELGSLDFWALDDDVRDGAFATLRREAPISFWPTIELPGFVAGNGHWALTKNDDVFYASRHPDIFSSYPNITINDQTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQRIFHWTNVILGFGDPDLATDFDEFMQVSADIGAYATALAEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS
The following text describes a protein:
Function:
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. RPA14 seems to play a role in the stability of subunits RPO26 and RPA43. In vitro, the RPA14-RPA43 subcomplex binds single-stranded RNA.
Miscellaneous:
MISCELLANEOUS: Present with 3100 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTISGNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKETSIGVSATGGKKTTFADE
The following text describes a protein:
Function:
Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
Sequence:
MRMIDIIEKKRDGHTLTTEEINFFIGGYVKGDIPDYQASSLAMAIYFQDMNDDERAALTMAMVNSGDMIDLSDIKGVKVDKHSTGGVGDTTTLVLAPLVAAVDVPVAKMSGRGLGHTGGTIDKLEAIDGFHVEIDEATFVKLVNENKVAVVGQSGNLTPADKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGSGAFMKTLEDAEALAHAMVRIGNNVGRNTMAIISDMNQPLGRAIGNALELQEAIDTLKGQGPKDLTELVLTLGSQMVVLANKAETLEEARALLIEAINSGAALEKFKTFIKNQGGDETVIDHPERLPQAQYQIEYKAKKSGYVTELVSNDIGVASMMLGAGRLTKEDDIDLAVGIVLNKKIGDKVEEGESLLTIHSNRQDVDDVVKKLDSSITIADHVVSPTLIHKIITE
The following text describes a protein:
Function:
Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine.
Sequence:
MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAWW
The following text describes a protein:
Function:
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAYHSHYNSDTGFKLCCGIPLVPLNPAGSESSFDPVEEAIELFRPNSLFKNFEFRGPGDKLLVYLIIFINSCLRRLAERKPGPPREEARQLLYAHAHDRFALPGQAGFPLSGLFTAPASREEEDSIRTYLRQCREEVGRRLLDRLYGPAAAAPGGSGAPASAAASCAAATPNKHWMAFANRRFLDRTM
The following text describes a protein:
Function:
Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Endosome membrane. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell projection. Note=Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-183 and promotes its internalization from the cell membrane (By similarity). Detected on brain astrocyte processes and astrocyte endfeet close to capillaries (By similarity).
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
MSDGAGAAARRWGKCGGRSCSRESIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYITAQCLGAIIGAGILYLVTPPNVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGSYTEVEDNRSQVETEDLILKPGVVHVIDIDRGEDKKGKDSAGEVLSSV
The following text describes a protein:
Function:
Promotes dephosphorylation of transcriptional activator STAT3 by interacting with both STAT3 and protein phosphatase PTPN2. This promotes interaction of PTPN2 with STAT3 and mediates STAT3 dephosphorylation by PTPN2, leading to negative regulation of STAT3 transcriptional activator activity. May be required for spermiogenesis or sperm function.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Localizes to both nucleus and cytoplasm but located predominantly in the nucleus. Detected in the sperm acrosome prior to the acrosome reaction and is likely to be released from acrosome-reacted sperm.
Sequence:
MKAGRGTLGVCLAKQSQGGDPDKLACGLKKRSQKRNPSPSVVPSWTDQPVADSHGKSRATGAAASEMKHGQSKASLLHHGGFKVLQSLKGSVGRSSAPAASLGKAVALSPAPSEEQLAGMSHGIGDALGSDWPGREPRATDNRGQYLKGESWVSGRPGHPKLREVGFLRGEPPSAGPKGLGTWSELSHRYFELGQLPYAYPYYKVLPEGELRCVSLDRFNPGLSEETVEDEKTLKFFRWSADSRGVTGSAIFQISKSLMP
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MRYSTNIIKKGILSRYCSNIYGMQYIPRARYFLTFCKNEKCNTMLKKYHPFSTSKMSDNAHYKGEDMNKMKNKENKTNKTNKTNEANKANETNETNETIENSASSPTEGKKKKNSLNESEEANEKKEDINYEDFNKIDLINEIKKTKRDMEEKMVDNKVLKEKYLSVLAENENLRNRYMKEIETSKLYCISNFAKSLLDVADNLSLAIKNINEESLKTNEEINNIYKGIEMTETILHNIFNKYGIDKYNPINEKFNPQLHEAIFEINDSTKEKGTVATVIQHGYKIKDRILRAAKVGVVKN
The following text describes a protein:
Function:
Essential for the viability of mitochondrial petite mutant. Catalyzes the committed step to the synthesis of the acidic phospholipids; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Subcellular Localization:
Mitochondrion.
Sequence:
MRTYIRYSRPLKAVQRTMSTNRTPMNGLEGIFDAVKGSLSSLRTIFYFKEGEIDVLQHPVEFYDTLKQKIAAANDRIFLASLYLGRTEHEVIACLDDALKAKPHLRISLLVDGLRGTRETPNPCSASLLAKLTKEHGDRVEVRLYMTPEYTGWKRALFPKRFNEGIGLQHMKIYGFDDEVILSGANLSNDYFTNRQDRYYLFKSKHFADYYFKMHNLISKMSYQAKYSNTKQSYMLYWPKNNATIEPRLDKHKFVTQASELLSKFLTATHENGMEGVQYLDDYPTIVYPISQFTPLFKKNNDFSTEKPSILRLLSSIPSSETSWAFTAGYFNILPEIKKRLLDSPSCVGKIITAAPTANGFYQSRGISKYLPDAYLYLAQKFLKSVHAEGKSDTISLYEWQKGVVNQPGGWSYHAKGIWISDGCDEDSRPVVTVVGSSNYTRRAYSSDLETNAIILTTDDRLRAAMGAELQNILRHTKKITLNDFTNDPQRYVKPGVRAATEVLGKKL
The following text describes a protein:
Function:
Dual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1). Also binds to G-rich DNA motif 5'-GGGGGCAGTGG-3'. Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression.
Subcellular Localization:
Nucleus.
Sequence:
MDHQNYQYQNPFERRPILKSKAPAVKWIKEWVPQDIVATGGKCHLHKWVTEDTFSRLKEKEKEPDVPEPEPEPTTEILFLCSYDGCGKTFFDVSALRKHSHIHGERQYVCDQEGCGKKFLDSSKLKRHYLIHTGERNYICTYEGCGKAFSLDFNLRSHMKTHSQENYHICPYSGCVKRYAHEYKLKNHVAAYHEKNGGGETPKYTPPAEKVLRTVKTPATVCGPSSDRPYACPYEGCEKAYIHEYKLKLHLKREHPGHLQEENADTPTLNKHNGNDRNEIDDGSDQDVYRKHASNGKGQTHKQQSRAKPNMRTPPAKVGKKGSTSSPAKARIAKKPWQAKETFEEVEREEEEDSEETEEDRDNVEDGWRFGENNEDDDDDEETEYED
The following text describes a protein:
Function:
Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.
Sequence:
MSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFSYGVQCFSRYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGITHGMDELYK
The following text describes a protein:
Function:
Essential for the invasive blood stages of the parasite. Binds to proline rich sequences in various regulatory formin-like proteins and also to membrane phospholipids. Binds to actin and affects the structure of the cytoskeleton. Weakly sequesters actin monomers (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton.
Domain:
The actin binding residues are poorly conserved between Plasmodium and other organisms. The Plasmodium-specific profilin mini-domain may have a role in binding to membrane phospholipids.
Sequence:
MAEEYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEESDPNFDKWSLFYKEDYDIEVEDENGTKTTKTINEGQTILVVFNEGYAPDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGLHLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAESSQ
The following text describes a protein:
Function:
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular Localization:
Cytoplasm.
Sequence:
MTQTDTDLFKRLTDRLTPPAARLTLAGLRGSSPAYLLARLIGEAGAPFLVVVPDAEAAAELTTELRFFTGRPGDILLFPAWDTSPFEKASPHADVTAQRLAVLRRLADRRAAAVVTTPEALRQRVVPRSLLDSASLYFLPGEESDRDDLLSRLVTLGYLNVPLVEDRGTFAVRGGIVDIFPPGFDLPVRIEFFGDFVDTIRSFEPLSQRSLQPLEELLLLPSRELLLTADTLQGAASRIKTRCDDLEISPLVRRELLEQLQNGLYPAGVEWLLPLFHQNLETLLDYAGDAVRVLVDPAAQEEEGERLSRELEEASDRARERGELFPAPESLFLAPADTAAALAAGRLVTIPFLHLNEGDSPETIDIATETNADLKVDISPDSEGVLRPLAARLTGWIEERQRVIIACHQRGQAQRLYELLAHYPVPLTVSDRPFPAERERDDGRVDIVIGEISRGFRLPEGRLVVIAEEEIFGKRQKRRGITELRKKQIMTSLAELKPGDHMVHLDHGVGIYRGLQHLSLSGCAGDFLLLEYAGGDKLYLPVDRLSLVQRYVGSEGIEPRVDRLGGTSWEKAKGKARAAVQEMAEELLRIYAARQLHEGHRFSPPDDLYREFEASFAYEETSDQLAAIEDVIADMTSNRPMDRLVCGDVGYGKTEVAMRGAFKAVMDGKQVAVLVPTTVLAQQHLETFRARLGAYPVTIEMVSRFRTPKEQKDILERVKKGTVDVIIGTHRLLQNDVTFKDLGLLIVDEEQRFGVTHKEKLKKYKAAVDILTLTATPIPRTLYMSLMGIRDLSIIDTPPVDRLAVKTFVARTSDELIREAVLRELRRGGQVFFVHNRVQSIGAWYEHLRRIVPEAKIAVGHGQMDEGELEKVMLGFMHGETNLLLCTTIIESGLDIPSANTLIVDRADTFGLAQLYQLRGRVGRSRQRAYAYLLIPGEGAISSDARERLRIIQELNELGAGFRLATHDLEIRGAGDLLGAKQSGNIAAVGFDLYTELLEEAVQKLKGEEPVERVEPEINLRVPAFIPEDYVREPNQRLVIYKKLTQATAEEEVGEVMEELVDRFGTLPLAASYLLDVMKLRIMLKHFLVRMAEFDGKRLCLSFHEKTPVSPDTIIGLIKANPKRYQFTPDFRLVAELADTSFEGVLAEARNLLKRLG
The following text describes a protein:
Function:
May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives. Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear. Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs. May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA. Exhibits decapping activity towards dpCoA-capped RNAs in vitro.
Sequence:
MAAGRPGVGVGVVVTSPRHPRCVLLGRRKGAVGAGAFQLPGGHLEFGESWEECAERETLEETALHLKNVRFASVVNSVSVKDSYHYVTILMKGEVDVTHESEPQNVEPEKNESWKWVPWEEFPPLDQLFWALRCLKEQGYDPFKEDFNHLVGYTGNHP
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSQVHALSDDQVGQELRKMTAFIKQEAEEKAREIQIKADEEFAIEKSKLVRQETDAIDSAYAKKFKQAQMSQQITRSTMANKTRLRVLGARQELLDEIFEAASAQLGQATHDLGRYKDILRDLILEGFYAMNEPELVIRARQADYDAVREAAGWASAQYKHKTDKDVKATIDAENPVPEGSAGGIIIVGGNGKIDIDNTFEARLTLLKDSALPAMRKALFGENPNRKFFD
The following text describes a protein:
Function:
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
Subcellular Localization:
Cytoplasm.
Sequence:
MNGEKGLYFRENPEILYEVKAQGGGLKDKETLRCKGWRQETILRMLEFNMENAEIPELLVIYGGNGKCARNWESYWAIVDSLKNLEDDETLVVQSGMPVAIFKTHKEAPVVVMATTNIMQATWERFYDLQDKNLTIFAQYTAAPWEYIGTQGVIEGTFETLSAIAMKKFNDDLTGKIYLTAGAGGMGANQTWAMKMHGGVCIVVDVNEKILKKRIEKDYLDIIAPTLEEAIKIAKENAKAKKPISIGVVGNAADMYEKILASDFRPDICSEMCPCHDPISYLPSGYTAEEADELRIKDRDKYLHLARETMKRQLAAMVALKADGVEVFEYGTSIRKECMDAGFPREEAMKIKGFVAEYIRPLFCEGRGPFRWTCLSRDPEDLKVSEEIALEICKGDKLVERWINLARKNLPIEGMPARICYMGFGERKRFGLAINQAIKDGRIKGTVAFSRDNLDSGSIVNPTFESENMPDGGDYISDWPYLNALLDCAGGCDLIAIQQNYSMGEAVHTGVTMIADGTEEADRRLAACLTTDSGIGVIRHAQAGYKAAKDVANGKGKFTTDSIKVPLWWQPAEKVTFGPKGKYR
The following text describes a protein:
Function:
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAPRLLLLPLLALLSVALTGVYVADVVSTKTHASACEMTWSWPVYSPVTWRSSPSHAKYQLFRVDMKQERTSLAGVPVLFVPGHMGSYKQARSLSRHLWDADETLFDLFALDFQEEPTGLNGNFITQQATFLNDAVRAILKEYKKQNKKKVESVVIVAHSMGGIVARTAEFLPNYKKRSIQHVVALGVPYETPPFPFDAEVNAVYDRMKMRRDEQVVYVAVAGGHKDMLVQTPFTSVDSVADPSRAFVTLASAIPTVETPVDHFCLLWCHQLLKVVAESLYKAVDLETRELVRNPNVRLAIAKETLLGGVVGEDGEIETASNVSLHRAYVQDGYYPGEYAGYTLLLPHFLTNLLRTRFMTMIVIMYALTLQIFYAQVAQWQTRFNLQSSASPQDLSQENFPSFTSMLHPAAHAPVFLKNIVAVVSNVLHGRSNLGTSTTTTVATAVLALVAAAVAGYMGYGKLLSDDKTASSLVTMVAEVAILYAYALGLLYALTHLFSVLQRFVVSPIVSILDNVTDRLKLRRWMVIIIIHGAVQLLGHINSSSSSSSKVFGLVVVAAFAVFVLYLFVLGGSNDGTSDQQRMKRSLFAVLWLSVFPWVGKIAFFASIVQWPPSELPNDLLVEGGSYIAILSACTYLISLSLDCMTPLPPTAFFGASSGQDAASIYGKSSSSNVKITAENCPKCIFEDGGPGAILEEYSDRTTRRVVAGKTGEVVYVGPTFRVVSCDCVYRFKNSRDFCDFCIRSCRLCGGGNGNFQEAAKYKDFLEESKVDLAMHALVPMAFQMCAAVQVTYGLYQAHLSFYLTPNIQEEKIIKQAYVGAKFYDHDHQ