lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Sequence:
MGYEYDPTEGLRNTLSKMDQELPRGEGCFSARDQLIRAAFMERLVRDNKARDSPFRALLEMLVCERLQKKGVKPKRAQTATQERNGATSPTRAEVNNNTASSNYLSLPPKRDVYQSESSSSLDSLDATLPPNRTPADTDRPQSARGRRQPGGFVIRRPSRSDIESVHKLISKSQQYREPHRNTSAAMQRMEEALKGDRFHDGEGDKLDVDKMLGKYASSVIMPGGPQLLARSSLHNSLSARNGERGRTALRPDSVSAGKPPPLHVPRVAAFPSLKQEPWTGSEDDPLGEKLRGSPGHGEVESAALRSKAGTDDIEISDVTDQETCIDRFVVSHKLVNFRPITVEEATVGSYYKDPRFPIWIVLSESHFSVLFSKCRLALDPGERQFELYYYDGLNKQDDEIRLTVDPNAGVTDDDIVMTPPLELCIRTRWKGASVSWNNVEPLL
The following text describes a protein:
Function:
Required for normal ER Ca2+ handling in lymphocytes. Together with PACS1, it plays an essential role in stabilizing peripheral lymphocyte populations.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPTESGSCSTARQAKQKRKSHSLSIRRTNSSEQERTGLPREMLEGQDSKLPSSVRSTLLELFGQIEREFENLYIENLELRREIDSLNERLAGEGQAIDGAELSKGQLKTKASHSTSQLSQKLKTTYKASTSKIVSSFKTTTSRAICQLVKEYIGHRDGIWDVSVARTQPIVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYVVQLPTPQPVADTSISGEDEIECSDKDEPDLDGDVSSDCPTVRVPLTSLKSHQGVVIAADWLVGGKQVVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPRSSRQGHRRMVCCSAWSEDHPICNLFTCGFDRQAIGWNINIPALLQEK
The following text describes a protein:
Function:
Putative serine protease inhibitor.
Subcellular Localization:
Secreted.
Sequence:
MSISSALAMVFMGAKGNTAAQMSQALCFSKIGGEDGDIHRGFQSLLVAINRTDTEYVLRTANGLFGEKSYDFLTGFTDSCGKFYQATIKQLDFVNDTEKSTTRVNSWVADKTKGENILLFYFDNILNSFIVSSLQNCQI
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport.
Subcellular Localization:
Cytoplasm.
Domain:
The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain; In contrast to classical PTS systems, the fructose-specific PTS has no requirement for HPr and Enzyme I; FruB combines a IIA domain with an Enzyme I and a HPr domains.
Sequence:
MSSPSIAPVTPDLVRLRATARDKDDAIAQAAQLLVAAGCVAPGYDASMRRREGLANTFLGHGLAIPHGVGEDRHLVRRDGIAVLQLPEGVEWNPGQTTRLVVGIAAQSDTHITLLRRLTRLIQDPAQLEALFTTDDPAVIVAALTGDRAPDTSAAPATDLAERFEWTIAYPSGLHARPATRWAETARGFSARAQVRAGDQAADAKSLVGLLQLGLRAGDSITVSAKGSDAPALLKRLRAVMDSLTAQEKADAERAAQRRAAPVIGWTPPQAQPAIVGIGASPGVAIGIVHRLRAAQTEVADQPIGLGDGGVLLHDALTRTRQQLAAIQDDTQRRLGASDAAIFKAQAELLNDTDLITRTCQLMVEGHGVAWSWHQAVEQIASGLAALGNPVLAGRAADLRDVGRRVLAQLDPAAAGAGLTDLPEQPCILLAGDLSPSDTANLDTDCVLGLATAQGGPTSHTAILSRTLGLPALVAAGGQLLDIEDGVTAIIDGSSGRLYINPSELDLDAARTHIAEQQAIREREAAQRALPAETTDGHHIDIGANVNLPEQVAMALTQGAEGVGLMRTEFLFLERGSTPTEDEQYQTYLAMARALDGRPLIVRALDIGGDKQVAHLELPHEENPFLGVRGARLLLRRPDLLEPQLRALYRAAKDGARLSIMFPMITSVPELISLREICARIRAELDAPELPIGIMIEVPAAAAQADVLARHADFFSIGTNDLTQYVLAIDRQNPELAAEADSLHPAVLRMIRSTIDGARKHDRWVGVCGGLAGDPFGASLLAGLGVQELSMTPNDIPAVKARLRGRALSALQQLAEQALQCETAEQVRALEAQREGQA
The following text describes a protein:
Function:
Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Sequence:
MLQSLPRATRLRSSLLTARLVSSLAKTSLTQTQTRLLSTSRAVFNNRKPYEAARDEFLRKRDANMKRLGVSEEEYRELFSKARKQRRQQDVNSTILYGLSVVIAFLGLSYLAVPVYRIVCQQMGWGGQITPGGNMKTGDYENPRFAAERLKPIEQGRHIRITFSGDVSGILPWDFRPQQREVSVIPGETALCFYKAKNRTDKDIIGMATYTVTPAIASQYFNKIQCFCFEEQQLLAGEEVDMPVFFFIDPDYATDPNLRGISDIVLHYTFFRAKYNDDGVLSPVATAEASEQELASQLQIAKEVEAQAAA
The following text describes a protein:
Function:
Plays a role in RNA-mediated gene silencing by mediating transport of both ingested and endogenous dsRNA between cells. Not required for the uptake of dsRNA from the intestinal lumen.
Subcellular Localization:
Late endosome membrane; Single-pass membrane protein.
Sequence:
MPSKNCAKNLHACQWERDIALVFLGLMVLFNIGQVVYMNRARLYRLIRRGAEQIPADDEEPIIGIRD
The following text describes a protein:
Function:
Cyclin partner of the cyclin-dependent kinase (CDK) pef1 (PHO85 homolog).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes at the barrier septum.
Sequence:
MSLAFTLLTSKDNTDEDEEHLELSSFNQEKLLEMISVFLSRLTRLNDSKQEATESDQIPLSPTSLKNPCLIFSAKNVPSISIQAYLTRILKYCPATNDVFLSVLIYLDRIVHHFHFTVFINSFNIHRFLIAGFTAASKFFSDVFYTNSRYAKVGGIPLHELNHLELSFFVFNDFNLFISLEDLQAYGDLLLSWYRQNGQNYNPTDVSCSIESPISHTPQQNQQDEQPRRPIMDRRLLSSHSIG
The following text describes a protein:
Function:
Non-functional allele of the RF2 fertility restorer of rice varieties with LD-type cytoplasmic male sterility (CMS). Non-functional RF2 alleles are found in japonica cultivars Taichung 65 and Nipponbare (AC F1SZ44), and is due to the presence of Thr-78 which replaces Ile-78 in the functional allele. Functional allele is found in the japonica cultivars Fukuyama and Owarihatamochi (AC F1SZ42), and indica cultivar Kasalath (AC F1SZ41).
Subcellular Localization:
Mitochondrion.
Sequence:
MSTLVTCSLPGAVTTHASTRRFGGSQFQTSQASCISFKREVSAKAVLRSVRCNATQTQSAQRKSSTATVKRSDPKGKTQGPKLDDGSGGFPPFRFGKGGGGGGGGGGGSNYFGGFLLFTCVLLLDYLKEFEKNLIARRQRAGYDANNDMFQQ
The following text describes a protein:
Function:
Probable transcription factor that binds to the L1 box DNA sequence 5'-TAAATG[CT]A-3'. Plays a role in maintaining the identity of L1 cells, possibly by interacting with their L1 box or other target-gene promoters; binds to the LIP1 gene promoter and stimulates its expression upon imbibition. Acts as a positive regulator of gibberellins (GAs)-regulated epidermal gene expression (e.g. LIP1, LIP2, LTP1, FDH and PDF1). Functionally redundant to ATML1. Involved, together with HDG proteins (e.g. HDG1, HDG2, HDG5 and HDG12), in the regulation of flower organs development by promoting the expression of APETALA 3 (AP3) in the epidermis and internal cell layers of developing flowers. Seems to promote cell differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MYHPNMFESHHMFDMTPKSTSDNDLGITGSREDDFETKSGTEVTTENPSGEELQDPSQRPNKKKRYHRHTQRQIQELESFFKECPHPDDKQRKELSRDLNLEPLQVKFWFQNKRTQMKAQSERHENQILKSDNDKLRAENNRYKEALSNATCPNCGGPAAIGEMSFDEQHLRIENARLREEIDRISAIAAKYVGKPLGSSFAPLAIHAPSRSLDLEVGNFGNQTGFVGEMYGTGDILRSVSIPSETDKPIIVELAVAAMEELVRMAQTGDPLWLSTDNSVEILNEEEYFRTFPRGIGPKPLGLRSEASRQSAVVIMNHINLVEILMDVNQWSCVFSGIVSRALTLEVLSTGVAGNYNGALQVMTAEFQVPSPLVPTRENYFVRYCKQHSDGSWAVVDVSLDSLRPSTPILRTRRRPSGCLIQELPNGYSKVTWIEHMEVDDRSVHNMYKPLVQSGLAFGAKRWVATLERQCERLASSMASNIPGDLSVITSPEGRKSMLKLAERMVMSFCSGVGASTAHAWTTMSTTGSDDVRVMTRKSMDDPGRPPGIVLSAATSFWIPVAPKRVFDFLRDENSRKEWDILSNGGMVQEMAHIANGHEPGNCVSLLRVNSGNSSQSNMLILQESCTDASGSYVIYAPVDIVAMNVVLSGGDPDYVALLPSGFAILPDGSVGGGDGNQHQEMVSTTSSGSCGGSLLTVAFQILVDSVPTAKLSLGSVATVNSLIKCTVERIKAAVSCDVGGGA
The following text describes a protein:
Function:
Member of the two-component regulatory system RegB/RegA. Involved in transactivating anaerobic expression of the photosynthetic apparatus. It is a transcriptional regulator that is responsible for activating expression of the puf, puh, and puc operons in response to a decrease in oxygen tension.
Sequence:
MAEEEFAELGSDRSLLLVDDDNAFLTRLARAMEKRGFQTEIAETVSAGKAIVQNRAPAYAVIDLRLEDGNGLEVVEALRERRPEARIVVLTGYGAIATAVAAVKMGATDYLSKPADANDITNALLAKGEALPPPPENPMSADRVRWEHIQRVYELCDRNVSETARRLNMHRRTLQRILAKRSPR
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Preferentially interacts with tRNAs with mature 5'- and 3'-termini and does not distinguish between intron-containing and spliced tRNAs. In the nucleus binds to tRNA and to the Ran-GTPases GSP1 or GSP2 in their active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the tRNA from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Miscellaneous:
MISCELLANEOUS: Present with 3490 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm and the localization is regulated by SNF1 kinase, nutrient supply and stress.
Sequence:
MLERIQQLVNAVNDPRSDVATKRQAIELLNGIKSSENALEIFISLVINENSNDLLKFYGLSTLIELMTEGVNANPNGLNLVKFEITKWLKFQVLGNKQTKLPDFLMNKISEVLTTLFMLMYSDCNGNQWNSFFDDLMSLFQVDSAISNTSPSTDGNILLGLEFFNKLCLMINSEIADQSFIRSKESQLKNNNIKDWMRDNDIMKLSNVWFQCLKLDEQIVSQCPGLINSTLDCIGSFISWIDINLIIDANNYYLQLIYKFLNLKETKISCYNCILAIISKKMKPMDKLAFLNMINLTNELTYYHQAISMNPQIITFDNLEVWESLTKLITSFGIEFTIIIEQVNDDQKLDTLYKQSVISNVDSILLEKIIPILLEFMNNEFDSITAKTFPFWSNYLAFLKKYKASSPNFVPLHKDFLDNFQQICFKRMKFSDDEVTQDDFEEFNETVRFKLKNFQEIIVVIDPSLFLNNISQEISANLMNCKNESWQIFELTIYQIFNLSECTKNNYFGLNKNEIMTSQPSLTLVRFLNELLMMKDFLLAIDNEQIQILFMELIVKNYNFIFSTSANTANATDDDEKYLLILNIFMSSFAMFNKRENVRLRSWYLFTRFLKLTRINLKKILFANKNLVNEITNKISPLLHIKVTSINAQGTDDNDTIFDNQLYIFEGIGFIITLNNSSQELTAATANTPIDYDILDQILTPLFTQLEGCITQGASPVVILECHHILMAIGTLARGLHIGLVPENQVNNMVVNKKLINDSLIHKFSNIAEVILVTFSFFNKFENIRDASRFTFARLIPILSNKILPFINKLIELILSSTDLKSWEMIDFLGFLSQLIHMFHTDTDCYQLFNQLLTPLINKVHSIIEEIDEQHDQQSSSNKPIDTAVTATSVNKNIVVTDSYRDKILLKKAYCTFLQSFTNNSVTSILLSDINRAILPVILNDLVTYTPQEIQETSMMKVSLNVLCNFIKCFGNGTCLDNDDINKDPNLKIDGLNEYFIMKCVPIIFEIPFNPIYKFNIKEGNFKTMAYDLARLLRELFIVSSNPTTNENECVKYLTQIYLPQIQLPQELTIQLVNMLTTMGQKQFEKWFVDNFISVLKQGQ
The following text describes a protein:
Function:
Probably a ssRNA endonuclease; Might contribute to small RNA (sRNA) regulation.
Sequence:
MIYSMTAFARLEVKKDWGDAVWEIRSVNQRYLENFFRLPEQFRGLENTLREKLRQNLTRGKIECSLRIETKKQANAELNLNKELANQVIQSLQWIKAQAGEGEINLTDVLRYPGVVEAQEQDLDAISQDLLTAFDDLLTDFIAMRGREGEKLNDIIQQRLDSIAVETDKVRSQMPAVLQWQRERLLQRFEDAQLNLDPQRVEQEMILLAQRIDVAEELDRLQMHVKETTNILKKGGAVGRKLDFMMQELNRESNTLASKSINADITASAVELKVLIEQMREQIQNLE
The following text describes a protein:
Function:
Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D3) to 1-alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)(2)D3), and of 24,25-dihydroxyvitamin D3 (24,25(OH)(2)D3) to 1-alpha,24,25-trihydroxyvitamin D3 (1alpha,24,25(OH)(3)D3). Is also active with 25-hydroxy-24-oxo-vitamin D3. Plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.
Subcellular Localization:
Mitochondrion membrane.
Sequence:
MTQAVKLASRVFHRVQLPSQLGSDSVLRSLSDIPGPSTPSFLAELFCKGGLSRLHELQVHGAARYGPIWSGSFGTLRTVYVADPALVEQLLRQESHCPERCSFSSWSEHRRRHQRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDSVVSDLVRRLRRQRGRGSGLPDLVLDVAGEFYKFGLEGIGAVLLGSRLGCLEAEVPPDTETFIEAVGSVFVSTLLTMAMPSWLHRLIPGPWARLCRDWDQMFAFAQKHVEQREGEAAVRNQGKPEEDLPTGHHLTHFLFREKVSVQSIVGNVTELLLAGVDTVSNTLSWALYELSRHPEVQSALHSEITGAVNPGSYAHLQATALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDICVGNYVIPQDTLVSLCHYATSRDPAQFREPNSFNPARWLGEGPAPHPFASLPFGFGKRSCIGRRLAELELQMALAQILTHFEVLPEPGALPVKPMTRTVLVPERSIHLQFVDR
The following text describes a protein:
Function:
Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fission. Negatively regulates the mitochondrial fusion protein marf by promoting its ubiquitination, acting in a pathway that is parallel to the park/pink1 regulatory pathway.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MEFLHESVALGVDLLILGLCAREYVHYKRTAKVLKAAPQYNIDGDLKSVVERQRDKKIPYAVIRGTVTPIGVPLRSSLVPSVSGVLQIVKLHEHRVTRGFAGFWTEQHKLLHESANEMPFELRNQSHGVEIVDALSAAVLDVDVVYDNYEPSNLSLFDHVFGFFSGVRQRGLQTTEEVLREGSFLTAIGELELDGDTLRMQPSNEGPLFLTTATKSTLIKRFEDAKTTTILKLVVCSTISAILVAFIAKKLYRKRKQEREEAKIRERLDTERRERRARSRPHTLSQDQLCVVCSTNPKEIILLPCGHVCLCEDCAQKISVTCPVCRGSIVSKAAAFIA
The following text describes a protein:
Function:
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity). Important for cell envelope stability and growth.
Subcellular Localization:
Periplasm.
Sequence:
MRLIRTLFVAALAMGASLAHADDSAAVQRLTGLLNKAQTLTARFSQLTLDGSGTRLQETAGQLSLKRPGLFRWHTDAPNEQLLISNGEKVWLYDPDLEQVTIQKLDQRLTQTPALLLSGDISKISESFAITYKEGGNVVDFVLKPKTKDTLFDTLRLSFRSGKVNDMQMIDGVGQRTNILFFDVKMNEALDAKQFTFDVPPGVDVIQE
The following text describes a protein:
Function:
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
Sequence:
MSCFSAMSAPLLGEMEQTIGMLERGTIVTKLYGKQRRPDRRHLMLIRETRQLLWATVATQTPRTDYEGAIQLREIREIRVGKHSKEFRLFADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLRYMVKDTLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMTTGKFMEHFTEDVRRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVVRPAELKQFLETEQRDVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSKQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDRNEQHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFREHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMKSDSFNPNNPLCDGLSEVKVSIRLIAARHLFRGGKSNNPQIVVELIGASFDTGVKYRTKVNENGFNPVWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKIANVTAP
The following text describes a protein:
Function:
Protein that forms the 55 capsid fibers. These fibers are not always present and may have been lost in some lab strains. They may enhance the attachment of the virions onto the host cell wall.
Subcellular Localization:
Virion.
Sequence:
MMVSFTARAKSNVMAYRLLAYSQGDDIIEISHAAENTIPDYVAVKDVDKGDLTQVNMYPLAAWQVIAGSDIKVGDNLTTGKDGTAVPTDDPSTVFGYAVEEAQEGQLVTLVISRSKEISIEVDDIKDAGDTGKRLLKINTPSGARNIIIENEDAKALINGETTNTNKKNLQDLLFSDGNVKAFLQATTTDENKTALQQLLVSNADVLGLLSGNPTSDNKINLRTMIGAGVPYSLPAATTTTLGGVKKGAAVTASTATDVATAVKDLNSLITVLKNAGIIS
The following text describes a protein:
Function:
Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.
Subcellular Localization:
Nucleus.
Sequence:
MEAQRRSQQEKQTKGPVCGRSLPESQAASGTLISTVDRSPETSKRLSGTGLGRPKLCPQRGRPHSRRRHRTTFNPAQLGQLESAFGRNQYPDIWVREGLAQDTGLSEARIQVWFQNRRAKQRKQERSLLQPTAHLSPATFSGFLSESSPYPYTYTTPP
The following text describes a protein:
Function:
Toxic component of a toxin-antitoxin (TA) system. An RNase.
Sequence:
MIAIDSSVLVDLLADSAQADAAEACLRQCLSTGPVVVCDVVLAEVCSALRDGAEALSVLEDMSIRFNALEAKSALRAGEMQRRFRARGGKRERVVADFLIGAHAMLQCDGLITRDDSFFRDYFKGLKIIVPKPAA
The following text describes a protein:
Function:
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of pro-inflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes. May play a role in pro-inflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c(+) alveolar macrophages. May be involved in T-cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c(+) cells. May be involved in CD4(+) T-cell proliferation. Induces NF-kappa B activation in macrophages.
Subcellular Localization:
Cytoplasm. Secreted. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Sequence:
MNKEKELRAASPSLRHVQDLSSRVWILQNNILTAVPRKEQTVPVTITLLPCQYLDTLETNRGDPTYMGVQRPMSCLFCTKDGEQPVLQLGEGNIMEMYNKKEPVKASLFYHKKSGTTSTFESAAFPGWFIAVCSKGSCPLILTQELGEIFITDFEMIVVH
The following text describes a protein:
Function:
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
Subcellular Localization:
Nucleus.
Sequence:
MTDTDEAHASGSDYPHAQDLISTRRKKRSKIPECAANAQKEPLCSRQEDATPEESSDELSSTYTSSAEVDSSDSEIDVPAASGSKHHRKCSDAPSKQKRRSQPSRPQAEADAGVPDSESSDSSLPPQSPVRPFEASQEKKSKLNLKAIFAYHFRGRKFKAAAHRKYRSSGSQKTKKPSEHSRRRGGKQPMTASPQERRKRLKDRGFQFPFVEKHYGRKHIPLNMVLSYEQAAAKGYFQYVEMLKYEEHLKKALKALEASEDLERECLAVRKHKYLDDEGPISPIQETNDDDDGDNNCLGSDNPEDFDVRVVDNSSFIISSKIPNKRKSKARTKRVKSAGVVEVKKSAADK
The following text describes a protein:
Function:
Component of the TORC1 and TORC2 complexes required for the regulation of the cellular respons to changes in available nutrients.
Subcellular Localization:
Cytoplasm.
Sequence:
MSHIQSIFAQIRDPFRKLSFYSLPLSSETSSVDSNGLKNSLKDAYFGLEKALTNTDADLPLNLCDYIFFPIVPVLKSWYRVPSTGVEYAIQCVNLLYKHGWREAHNEMLTMQLLLMLLNIADGWKSPSETVEQDFRVREITFETLENVITDFKPNFHDKRQYLLFARALSSALDIIPNKNSSRRLQFASLCCVQKLICPKQYRLPTEFLTTFLPGIVSGLTKGLAPNGTCQYFKNVCISLNILGDTVVKAISDDNTKDLPDEKDASSNSHFFGPTKRTKSWKRATCQQLSNAVKAILHLRSSQNLHVQDALFDFCFILFRDCLDSLKDCRIHLLESMLKLINKKENPKLRDYGMNKLVSLIESFNNITMESVLTECLNDWSTTWSSVSTFASEDNKLEELNRLKSLLSISSHLPKTLQLMEPLLDGILSQLVPKSSGIDSNSQKLLTSSTSNEYIHGEFFGGNEMERTTQEIVTSFAKAPNVKYVMQSLLSKATSATNENSVRAFWAFMVLLKSDVETVDSLEMYIDSLEQYSFEVLQQLSQLNVFTKASLEDKQKKEKYNLLCVRSCIAIDSISWISSLQGVKFRSKLMAYFYPLLEHLAFASPYVSSFAEACIQAIATNCNYSTPAELLRENIDYVVNSVALKLNTLDVSPQLPIVMAYVIKNDDGGCIRYIGDVVDAIFGILDAYHGYARLTEGLLGILYAIIKQESINGEEKKLIVGVEEDAMNEDKNKPCKKIREFVQLLLENPNYPLPKDDHELEDMIHDEQQETKSGHEQFREHAMKEKEKKGKENENMGETTVDHENINSNVMDEQGEKQKDDVVDMVRKITEKAQLFLSHEQITIRVEMLKLLSYGSNVLAKEPNTFYPAINTFWPLVVIQLDTDNELLVECALETIYQVCALADDFMTSRIRQDLLPRLETLCQRWHLFNVARTYSSEHRLQRAMLKVTSACVANKLSIVVYLKLMGITAPIIRAITHMSQKYAGDESLVEETWNAFSKQNPDAVYYEREVRGSQMIDTFSTELLIPGKQRVQRTYRRTHEVLEPVGAKTSETVFNDLLGQQGSGKTETQEEPLPSLDNLLHLNQPKKGAKKPLISII
The following text describes a protein:
Function:
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
ASVAKRIRLGVCAMDKKARSKPMSEILNRLNPETFEPVFFGDAVILNEPVENWPVCDVLIAFYSNGYPLEKAEKYVTLRQPYLLNDLKMQRVLMDRRRVYDLLEESGIDVPRHVFMSRDGYEPDIEEHDDHIEVNGVVIHKPFVEKPIDADDHNIAIYYPSSAGGGCKKLFRKVGDRSSEFYPEINEIRRDGSYIYEEFIETQGTDVKMYTVGPDYGHAEARKSPAVDGKVERNPDGKEVRFPVILTLREKEIARRIVLVFKQQVCGFDILRIQEGDSLVSYVCDVNGWSFVKKSRKYYDDCAQILTEHMLATLKPKSKISLSTLAPLLATMEDSVDDMNRRRGRDFVPSTHQEELRCVITIIRHGDRTPKQKLKGDINGKRFLEYFQGHAKNVKKDLKVKAKQPMVEFLETVKAVIKDKEEEGAKKNREELYKARHIRDILLRWKFSGLNRKLQMKPRKWIEEETPDGNKVTKCSELQMIIKWGGDLTKLGEKQAVNLGNRLRNELYPESGGGGILRLHSTFRHDLKIKTSDEGRVMKTAAAFAKGMLELEGDIPPILVSLVHKEKSSGHMLDPSGNKEVKKDLEVSCTAIIITNLNMVGPERLISLHRALKEIGNPRKTLIAIHSTIGKLVEQLDDMLGELASGDEEVIEGGAGLKGKEENDEALSGIKLYKGETLLELTERWKLLQNKLYDEEKDVFDLSRVPDAVHDNVRFDMLHNPHLGLTETLQKLYDLAKSMADCVVPQEYGITVDEKRSIGSKMCATLLEKIKCLFSDILVLLLHLYFTMQINSFDLAIARTDNQVDMRYLINMDYSADLPINSMGRRVRSRLYFTSESHLHSLLNVLRFASAQPESVTSPLSVRGQEILASASELCYLTQVVIRLFEDTQKPAEDPRRFRVEIWFSPGATATPL
The following text describes a protein:
Function:
Acts as a transcriptional repressor (By similarity). Has mitogenic activity for fibroblasts (By similarity). Heparin-binding protein (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Secreted, extracellular exosome. Note=Secreted by exosomes and is located inside the exosome (By similarity). May also be secreted as free protein via an as yet unknown pathway (By similarity).
Domain:
The PWWP domain harbors the heparin-binding sites and is responsible for DNA-binding, while the C-terminal region is essentially unstructured; The N-terminal region does not contain a typical signal sequence but is required for secretion. It also determines exosomal location (By similarity).
Sequence:
MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCAAEPEVEPEAHEGDGDKKGSAEGSSDEEGKLVIDEPAKEKNEKGTLKRRAGDVLEDSPKRPKESGDHEEEDKEIAALEGERPLPVEVEKNSTPSEPDSGQGPPAEEEEGEEEAAKEEAEAQGVRDHESL
The following text describes a protein:
Function:
Probably involved in the formation of the dense core and M1 domain of the acrosome. May also regulate the release of certain secretory proteins following the acrosomal reaction.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome lumen. Note=Sperm acrosomal matrix. Restricted to the M1 domain of the apical segment of the acrosome.
Sequence:
MFPRLQAVSAPALLQITLMAVLLAPVLGDCGPPPILPFASPVIQSYETNFRTGTALKYNCHRGYWRVNSSHVICDINGSWIYNVFCAKKRCRNPGELANGKVEIITDLLFGSTIEFSCSKGYSLIGSTTSQCESQGKTVDWSDPLPECVIVKCDSPPDISNGKHSGTDEDLYTYGSLVTYVCDPNYSLLGNASISCLVANKTVGVWSSNPPTCEKVICRQPHIPKGIFLSGFGFYYTYKDTLVISCKKGYILRGSSIIHCEANSKWYPSIPTCEPNGCIDLPEVPYISWERNVLSLKNQEIFEIGSLLKYDCKTGYRPTPNEPRTVTCQENLKWAISKGCERVCCPTPNMEKMRIINERRDFTGVCVYAYEDYIFYMCDEGYYPISADGRSSCQADGMWNPKMPACESAVCLKPDILNGKLSVEKDHYTETENVTIHCDSGYEVVGPQNIICSENRTWTPEIPKCEWEVPEECKQVAAGRKLLECLPNPSDVKMALEVYKLSLEIEQLEKEKYVKIQEKFSKKEMKQLTSALH
The following text describes a protein:
Function:
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
Sequence:
MKIAIVGGPTAVGKTDIMIEVCEEIGAEIISMDSRQIYRYMDIGTAKPTPEQRKRVLHHMIDIIDPDEYYNAFMYRKDSLRAMEDVLRRGKIPVYVGGTGLYADALVRGIFEGVPADENIRKELRELERREPGILRKMLEELDPEAATRIHPNDLKRTIRALEVYMKTGRRISELQKEAKGDDRFFIIVLTRERYELYERINKRVDKMIEMGLVDEVKRLLGMGYSKDLNSMKTIGYKEVIDYLEGKYDFDKMVHLIKRNTRHFARRQIIWFKRYKEAVWYNLTFEDVGEVKEKLKKLIVENFSV
The following text describes a protein:
Function:
Inhibits trypsin and plasmin.
Subcellular Localization:
Secreted.
Sequence:
SIPPACDKYSRLPGCPRDYSPVCGTDGKTYPNECVLCLSNSEENKNVQIYKSGMC