lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
Sequence:
MSIGVPIKVLHEAEGHIVTCETNTGEVYRGKLIEAEDNMNCQMSNITVTYRDGRVAQLEQVYIRGSKIRFLILPDMLKNAPMLKSMKNKNQGSGAGRGKAAILKAQGMCSSCTVNICVCHVSFRKGPCQSSGHGVNLEPVQSCLFCLTSPVTFIGPMQNPKCLLRKKRKWISPYNDFLRDPFLSRKSVQRVWGRLALNLIC
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPISRYHIRNAHGLADPELHSAADKDDSEALLEAVAMSGLVGFLRQLGDLAQFAAELFHDLHEEVMATAERGHSLTSRVQQLEAEIPPLEKVFLSRTHHSSFFTNGGIDWCPNLRSEPHLVTRGDLPRFIMDSYEECRAPPRLFLLDKFDVAGAGSCLKRYSDPSFFKAEPASSVTATVEVHRERKIRKVRQKKGEWPRDGETPGVVPSHSKLHQLFLEERIENACTDPARLVKLKKRQLDGSAVETKSGRSYMEEILERPSPDHKMVRETSITPLPVKSMSDDTCEQKLELSRNYGISPMRRSMGNGEMHSSLNEHEIELNSYTQMDRTNGYLVKEPEQISSGGTDEMPSKHHNVPDETELEDDDDEQNKREFSLDRYHSDDAGSEADDYMDALATIDSDLEVDNECRPKKSLLNVQKVTDSYGEEEHQLQAQFSDSQSFGDSSLSEEISSFEQDRSEEHDEVPARLPDSHSAGTYCASDDHSLFQRDSNEEHTQPQAQFSDSQSIGNSSSETENMSSNQLPHTVESQKTCDEFFSHYDDAHDNGRAISDSGSVSSGTCPVDSGCLLLSLDHGATATSLAALPTKTQSDETPHVANHSNIEVMQTESLNEDCSEISVVGDIGSREENPICLPMEVDLNLGTKLLLDDRDFKSDNDNNKAMQLDSEDSFPVLETNVETSFTEELCSDFTHGNPQDEPDSAEVEILYPDQLSNFKEVPMTMLGDEINGPTCSLDTVEDDDRMKHPASPDCILQDDYVMVNNMFPVTVQSKDLDVSAVSSFDSADTGASIANCLASDSISSPSMNPSNLHESLLGSKDSYRMEIESIDLTKVSVDLNAEKKEYQLEPFSYITSPVGSLTKLEESLSTFEYPHEKKMEVNEEVARDSLTELTSHTVVEQPDIASTDKQLNLNKTVPSDSSDSGICNDFQHSLPKEKIQDGSPLNDMKMATQCSELDSGSESVFACQNDLQNSKNGFSPPSYNRQDPESHIEFTSEVHPEEPSHCYLSMSSDQKINPTKHVMDPMKPLLPDLFPKETKINLEETPPMPPLPPMQWITSKVQNASSVSQREETGVSQTSFQPVQPVKPDYNSQFGLSTSERVTSPYHNPFLPAVAVGSNKSLHSSGLSVGVSEYPVAIPLQFPVMVNEANGQHNYQVPERSQVHNPFLTLPMLSYGWLRHGSVIASEGESILISTPCPQILPAECAVFETDPIHQQEKLTQLTNQFMEDTSLEAQMDRTGESVLDSSPSRPILPTECAVPGADPIFQQDKPTQSFSQIMEDTNFEAKKDSPGELHFELPAECPVSVDDSISPKEQDFDSPNQIMEETVLEFTTLDESSIDLVRNQGDHLVSPESPPSTEIVQPNHSMQPSEGDLALSLDKSAQSLAFDSQIPNGKSKNKLPPPPHNHLFDVVAALDKSRLRKVTDRVRPPIAPKVDERDSLLEQIRTKSFNLRPAVATRPNVQGPKTNLRVAAILEKANSIRQALAGSDEDDDADSWSDS
The following text describes a protein:
Function:
May link the scaffolding protein CASK to downstream intracellular effectors.
Subcellular Localization:
Cytoplasm.
Sequence:
MGKEQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNVPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDTTDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAQVRNTYSQTALDIVHQFTTSQASKEIKQLLREASAALQVRATKDYCNNYDLTSLNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRVGYFPSSLGEAIVKRAGSRTGSEPSPPQGGGSLGPSAPPEEIWVLRKPFAGGDRSGSLSNVAGGRSTGGHALHAGSEGVKLLATVLSQKSVSESSPGDSPVKPPEGSSGAARSQPPAAHAGQVYGEQPPKKLESASASASEGKSAEAVSQWLATFQLQLYAPNFTSAGYDLPTISRMTPEDLTAIGVTKPGHRKKITAEISGLNIPDWLPEHKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAVRKLAELQKAEYSKYEGGPLRRKTPQSLEMMAIESPPPSEPAAAECQSPKMTTFQDSELSGELQAALSGPAEAGAAAVEKSSNHLPPTPRTTSRESSLSGRARHISSSQELLGDGPPGPGSPMSRSQEYLLDEGMAPGTPPKEVRSSRHGHSVKRASVPPVPGKPRQVLPSGASHFTPPQTPTKAQPGSPQALGGPHGPATAKVKPTPQLLPPTDRPMSPRSLPQSPTHRGFAYVLPQPVEGEVGPPAPGPAPPPVPAAVPTLCLPPETDVEPGRPKKRAHSLNRYAASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPAGTDKNVNRSQSFAVRPRKKGPPPPPPKRSSSAMASANLADEPAPDVEAEDGRLGVRAQRRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAIRRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPDGEVVNRRRTLSGPVTGLLATARRGSGEPAEQSHFMEDGTARQRLRGPAKGEASAEGPPLARVEASATLKRRIRAKQSQQENVKFILTESDTVKRRPKAKEPDTGPEPPPPLSVYQNGTATVRRRPTSEQAGPPELPPPPPPAEPPPADLMQLPPLPLPDGNARKPVKPPVSPKPILSQPVSKIQGSPTPASKKVPLPGPGSPEVKRAHGTPPPVSPKPPPPPTAPKPAKALAGLQSSSATPSPVPSPARQPPAALIKPASSPPSQSASPVKPPSPGTPALHVPAKPPRAAASVVSGPPVASDCASPGDSARQKLEETSACLAAALQAVEEKIRQEDGQGPRPSSIEEKSTGSILEDIGSMFDDLADQLDAMLE
The following text describes a protein:
Function:
Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.
Subcellular Localization:
Nucleus.
Sequence:
MDWNTKWEWKNHDIFTSKVVTATPKKLQSTNWEDDVNESFNLSASDVANYSSAKSSISASTESSLKEGKQMSRLVYGEYIGAEVNGKSSLLEGSVSSGEPFIGLKLGKRTYFENSIGRKVSSFSDSPTPVQGVSSSTGKKAKSSCQGTALPRCQVEGCNLDLSSAKEYHKKHRVCETHSKSPKVVVSGLELRFCQQCSRFHSLAEFDEKKRSCRRRLSDHNARRRKPRQETIQFNSTDLSSSFYGVRQQLSFQSRPAVSSTWKNSSNSTYSIATMKTKQSGILDGISQLPNAGSMPTISFSRPVPSKGTSGEVLDQGFKESLSPNVDALRALSLLSNNSWGLYEPDLIRLDQPHPMGSDNPFMVQPGLQTVPQGLPLSSSDYWQTEQHSIDPTKTSNAANTQVQEFQLFNRFYSNPMDEIL
The following text describes a protein:
Function:
Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.
Sequence:
MLNEFIAIRRELHQIPETGYKELKTQAYLLDYISKLPSGHLEVKKWRTGILVLVKGTNPEKTIGYRTDIDALPITEETELPFASKHPGNMHACGHDLHMSIALGVLTHFASKPAKDNLLFVFQPAEEGPGGAKPIMESTEFAEWRPDSIYGLHIAPEYKVGEIAIKPGLLFANTSELFISFKGKGGHAAYPHLANDMVVAASAFVGQMQTIISRNIDPMDSAVITIGRIHGGEIQNVIAETAYLDGTIRTLSPETMEIVWTRLKQLAKGWEEAYQCEVEFHPGSDYYQVDNDPVETEEFIHFLEEQYPESYVPARSAMTGEDFGYFLSEIKGFMFWLGVDSEYSLHHAKLNPKEEAIPFAIDVLIHFLESK
The following text describes a protein:
Function:
Probable oxidoreductase.
Sequence:
MNMLEDLESLQFEYGIQEEDHSWLYLQGRFRGLMIKACAHATFFCKLLCNLRESLHEKQTSRCVLTGLLAAIPNDELKVGIIGGGNLGKQLARVLLQLVPIPAENLRISTRRPEVLDEFQKLGIQCFYHNPYLVDWANVLFLCCLPSQLPNICLEIQTHLEKGCIVYSFVAAVPIARLKLLLNHTNILRPQYQCVENVNIWGAGKDITAALQDPVILQATCPYSAAGGIILNIKWLEGVFHAALNICTAKDMPHLQVLQLLNELFLSVHFEDCEKDEASCPKFQLQDFVDQVYTKNLPQRRPFPWFDLTAVQLKETSFTQHFSTSTAFRDHLTYLYCDLFGISFTKEQQPGVSTSSSSK
The following text describes a protein:
Function:
Required for ciliogenesis and for structural integrity at the ciliary tip.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MQRKIKFSVISSSSHEDHFSAEELMVHAPTVRGWRSSRYSLTSDLYHKSCPFGSNLSLFCWNQVKVSPMFCRLCSFPQYILLQLEGRSRVRKLQLLAHQYLIPTKVEFHVGDVGPEDGSSELQLRRLGYVSLSDNEKTGFQARELKSVHVDAVGTFLKVSLYRNHVNRLNHYSQVSLVAINILGESVGAVGWMQSREPPNDRPPLQQEAAWEKTLKGACEAMSPLDDLAFDMYQDPKVAHIIRILDQKKKDMVQQENFEQAKTLKQAIADLQKVGERLARYDVEKRRAIEEEEYDLAKKKKELMEELRRNIYRQLEEHDLLDIAVVTPPPPLLGSPGCHGATEPDVSADAFRNEARGDEKMEPPDEHHRREDKPPPTAKPPRTDVLGDERPLLTLQRKDWASGSLQSAALQAEKTPAGRGTSLEPLTEGAQREAGPAVDVYGESLVAEAYSRSWCGREHALLAVHDKLLEASSAAPKEELSHMIRAAGPLARRALLDKVPPVFYASLKLLRLILVQIIPCVGLGRAEAAHCLQQTFPHLLRRTGDRAGRPRAAAVAFIQEIAVLKEVRSLQMIPAELLKPFTSNVPPRLAQSRLELLEKLLAELGAESFAPEAVVRFCRVALEHGAKEVRELAVRIILSLYQQHRGHVLDLLPPRDAATPKNFLYKTLFDGFSRIDGRLMEAQDLKQGGVLPGEEARSLQEQLAVLKEITEWGGEGAPEDPHRPTQEPPKAAKAGLTKGDGKRGGANAQQPAEHLDHLCIFCGEKDESFTEDGLDLHYWRHCPMLHRCHECGQVVEISGLSRHLLDECESRSRFRRCPRCCQALPAEDLNRHLQGSSCRCLEGSPDGQEGLQTKRTQDCGLPENPASTREGRQTGAPVSSEGQNRACGQMQSDLLQTLRNHAGSTVPRHRTGLE
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
Subcellular Localization:
Nucleus.
Sequence:
MLEKGLESMRIHGFTKELIHVAWRFVLIRKAIKNRGTYSTLCTESICFDTTRSLLLLFLTVGTSRVRLPPSRSDTGIKSYCDLAMAKLKEGDVTGASELFQRAVTITPSMAHQLIQILRTENIEFVVAPYEADAQLAYLSNLEADKGGIAAVITEDSDLMAYGCRAIIFKMDRYGNGEEMVLDRVFDSVARAPSFQNFDKELFTGMCVLAGCDFLPSVPGIGIARAYSMVAKYRNLDRVLSVLKFEKRNQMPEDYTKSFREAVAVFQHARIYDADTKRVQHMKPLTDDLLQSLDGELDFLGPEIPPSIATAIAEGNLDPVTMEAFDHFSSHESQPEPTVTQTSNEIVKPEATAQSTEESCFTIFSSHETREERVTGKSRPVIEETKYLNEAVALQKIMFPSEVHGMLENKITQDETPLEIPDNNPFKKRKLNEIYLDQIPSITEQISVVVDVDNSDIMCVTLESQESVDSKPNKVADRKAISKNEKRKRSDCKSSESKKNSILNFFSRV
The following text describes a protein:
Function:
Cleaves the polyglutamate sidechains of folate polyglutamates in the vacuole. Is important for polyglutamyl tail length determination before vacuolar exit. Plays a role on folate stability and intracellular folate content. Has endopeptidase activity against 4-amino-10-methylpteroyl penta-, tetra-, tri- and di-gamma-L-glutamate substrates and is responsible for the production of folic acid, also called pteroylglutamic acid (PteGlu) from teroylpolyglutamates.
Subcellular Localization:
Vacuole. Secreted, extracellular space. Secreted, cell wall. Note=Extracellular or cell-wall bound.
Sequence:
MWSYVWLPLVALSLFKDSIIMAKAATILLPSQTGFDISRSPVCSAPDPNLNYRPVIGILSHPGDGASGRLSNATDASSIAASYVKLAESGGARVIPLIFNEPEEILFQKLELVNGVILTGGWAKEGLYFEIVKKIFNKVLERNDAGEHFPIYAICLGFELLTMIISQNRDIFEKMDARNSASSLQFVENVNIQGTIFQRFPPELLKKLGTDCLVMQNHRFGISPQSFEGNIALSNFFKIVTTCVDDNGKVYVSTVQSTKYPVTGFQWHPEKNAFEWGSSKIPHSEDAIQVTQHAANHLVSEARKSLNRPESKKVLSNLIYNYKPTYCGYAGIGYDEVYIFTQQRSLL
The following text describes a protein:
Function:
Represses the expression of most of the genes involved in oxidative stress response, such as rbr3A-rbr3B, dfx, rd, nror, fprA1 and fprA2, coding for reverse rubrerythrins, desulfoferrodoxin, rubredoxin, NADH-rubredoxin oxidoreductase (NROR), and oxygen-reducing flavoproteins, respectively. Thus, by controlling primarily oxygen and reactive oxygen species (ROS) scavenging, PerR plays an important role in the oxidative stress defense system in C.acetobutylicum, an obligate anaerobic bacterium. Probably acts as a peroxide sensor.
Sequence:
MNDISTIFKEKKLKLTPQRIAVYKYLKSTHEHPSAETIYKAIQSDYPTMSLATVYKALKTLAEVHLIQELNVGEGNFRYDANSSSHPHIQCLSCGKVDDIMGITFDNLNKDVSSHTDYDVISNKLYFYGICKDCKDKA
The following text describes a protein:
Function:
May play a role in microtubule-mediated transport or vesicle function.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVFSLNFWFAPSLSLQFHLSPSNFISLSLSLSLSQTLSLSNSLSLSLSLSLKLSQTLSNSLSLSLSQTLSNSLKLSQTLSNSLSLKLSLSLSLSLVTDEFLKILTVAVSGLLKACADVDSDVRMHADEHLNRLIQALMDRHLSRLQNELFKAVKMESAPTRMVRAALIKFADLVHLLKPLRRFKYVKVMVPRLRVLLASNDETLQETLATCMEKICDATGLYFADDQVQDLLTQLLENLNSESATVRRSSTTSAIAVCSGSSRPLYYLKLFLNSLFALTPTTHNNELSHAKEQEHTILGALLAFRKLMTEFSIKAQEAVTPDQLLDSHTNERLFHFLLACLQHESHNVLTGALEALIQQLDSIRGKLVHWMRQPERLHECANVLSRFILDPKRRDRVRDQLVRGNVYSLFGSLIKHSLVHTHLVFSDVPLPSKDLMEIGVFGVKPISVLELCRLLVEALNDSIATAARSAVAALRYCLPQVLKSTHGGVAVEIHHCILALRHSSYWLLKTELVDLIGETEYLLVHFLESSSVDLGDSALLPTTPVSMPQRHRNLTGQTLQDASLETILLLLGDADARVREASAACLLKLVSRLFYVEDWPGQDAFTALVERDVAFLTGIASKASWTATGRDQERPELHAHVPRANLSRLVAMLVARLYSSQSKTVIVGMYHGLNVLTARNNVPDIVQRPARGHPPAVQPEDVLPLALAHIKLSWIASDLGAHADVLNLVGNLLRSANKSYAAPFVLPLLVHVLRMINMCVHIFDKKVPTLNKTTKQERRSTTSSPRSDAGTTAPSAMDLADDLSPLPGKPLGYFTHLPYYIELYQLLHSAYVSNKITLSSQSVSKFGHMVRTCLEVLTILVEVEGSSFHQYAAEVLQYLQSVVAPEPRAVLLCVHQLIQALFEPPRIMIQTEGGLEGSLRVDSATLLLGYYERCIDDSPVTTRRRATGAKADKEAMFSFVRMFEPLVMRAMNLFTTTASVTLQQQIIFLICRLMQMRVNYRVLDKNLIFKTAVDSHYDSIVEGRVRKPQNLLSYMFQFLALLAMHQLRFALFPTLAYAAQDYPEIVTMESLIEKANRLLTSHHLTPRQAIPAFRPLVHELFVVQGHVKYPSAQLQAQQSLLLDSLLQMVSFSAVQEQLVALLKSISSDQDRYRSLSRKVVDALRSAINSQQVEVRSPRSLSILHTLLQSVAEVALSPIELILLDATDVAAAHVMKDLSVHDDEDACRYWLPQFIALQAVVARNDGHAVQSGLERMLVKQRLATPDAGNVSERAASTWMDLLFRAMLKCSHELAHGDAVSRTYTTQQMAQLLKHATAFLERLERDSWLLAAARSAARDAAATITANLQLIVFSDPLLIMLWSRLLSRVEATSDESVQVFAHDDPKEVLSVIRGASPDWARLLLHLVRERPLRSLLTTMCEHSPPLAMAACELLGEAIAEGANWPVAPAEQMSVMQTIDHYLASVSNEVALQKLLRIPLLAIQDDNEEMFAVYLRELGQHKCASSLPIRTLIEAYAPPISGDPAPDPKAVIRQALLDVPQGAVETHATSIARAILELPVDQLREVTTASWMPTSMFRPLLLVTVQTAERMAVIKPFKDSIDADNSSDQEYMEAVASRAGLSDEAASSQITDAVSKLRVVISSCLHTIEHCQTEPCVVHLAVTLMQLHRVSRTCSNPLWHYSGLQDCIQLDVATLQALLQYWLDESERCLRLLRAQARLTTEHLSATLTGIAELLAILSPEQLVGEQITTEGARDGHDAASPDGFMVAERIAPMIELMHELRRTARFGCFLPDPLTPQKSYEEQLTLALAEQTEPPMQPPLGADLVQRIVLAVRHGFGEALQLEGGCSDLRATPRLPAHLRVALNNAVAGLAHAVQMQLHQVGLCCNPETAKPSRHHGEFLAELQGSQGLEMRRQLLEDDLHPEPGERCRGVCSSLGGMLALLEQLLQQQMVNFHLQCSSAHVAPVITDSHCPFLNYKRPNFMQSQAGVRLLLALSSFGRSRSSLLLQLAHNASIFRRHSMLLPLQSQYHNTHGLELSTPARQCLNDYLELIQSIIKKQASGDNDHHLLAQQVADRTLLQTIHSCLLTLLHEADEEDYLLLRHLIPAVATAQQALVAVDAQVGLDEVFFAALLRGLRHAWPSMQTAALNAVRVAMPSLNVVNHEVLLVEVQTYCVTSLTSALSISSSANDEHIPPQSAVLRAVLLLVAEMVVQFRDACVETGFVGRVVSVLASLVEFASRELEASVLEALYACLEHMLLNFVLSVGECECVRQSIVRANLRPDVDTALGGHVWTFLLAALYTAGHFKLGSEQMQSPAGPQDTSSTMSHVPMEWVDYLTSLPAAQRQSASVAVAVVDMLRYCYPARDVLKDLMGRWSRGLSGMVMSSSRLDVVTYMQRLGTQTHFALAVFGNLMTTHGEAVCDWVAQSLSNYVHSPFVKQVMAALLLAAVPNPVFRALAPRPELRLETADLALQVLTTVCKEVMPEIQLTLALRLEAAGAEAGDADDTTNLVVDLSGPPSPDLATDSHATSSNTSLSLSLSLSLSLSHQLSLHLLVLSHTCKAVSWDDAQRGTVGGELSSIGGNITDTRLWAKDGRPLYTLRSDNWNEKLGVVSSDKVALLVGSHLEDASTLSPITLRTFLRRAGEYGGYAGVPAGTDLDAQLVDDKVSIRFQTVFLPVQDDARQRGALEFCTEAYNYNTHDDSDPRNLLLLCTTQGTAVQQDGRGAKKLYHHACHDGQIHRYWLEAERSSHAVGGAQEETEAERADALARGKATASVIGIPAMGTRFNVLMTVQVPLVQKPRSRSRHDYTMALQDGAAFPAIACSAFPMPGGGAPPCPSISSSSCVAHRGRLRSKAACRELLSGTANAARVSRGSQVDTWSGLSVKSPKRQPAPCTVTVVVYYTVAGGVPSPADVKAAVDDLEALYASCGATGRLNDAEFDFMKHELTTHEHHGVWQKVQDEPYKPVPVPVANYNVFPQSS
The following text describes a protein:
Function:
In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits.
Subcellular Localization:
Dynein axonemal particle.
Sequence:
MASEQDELLETAARDPDWFGVSGWEPVFSAIRAELPSIDSDDTSLSDREEEELHIFQREDNYIIPDLFKELLDDGELNSEAATRQVSPKKVESLELSESLASCPDLGIPTPVQTGDSDHSINSSNPDIEQLCPEPLDDVHIESEADIKDSEKEDELQHGLHSRVTTKPQSHSKYDVHLGGTGSEHLSSPTCSLKPVEPSLQFLECLEQWDLDAILCQLKEEEVQERKMPPLLLSMEESTERRHQCIMEQLVKFAAQHSEEVSSVPQLQRKDKDGTNTKSSFRPPPNRKGSLQDNGKDLQSLPTIYIDLRTTISKTGLDQVPGNPTQRNKQKEKRRLNKADHTGKSLLLQKRHNIQNGSLSDPNMPNPESAIKESTELGTPTQRKLRLKSKADISPKRQEVEEREEKDSREEPEKVEEIIQSLPPKSLINSRADEIAQREKQEKEKKARLRMLTQLEGLKPSNTVNGRQPMAEATPILFHPEASYSPSIGTLPDLARSGVETLLLTISLSSCGQVFIPGQHGARSPYSSLFLANTFHCLLTWLISLVPGFNTHGMGNAPFHVLGLQQAWQEEGLALYACLSPREMATQSSPKIRKHKGKQDLRGTSSFYQQVSLFLSHDTLQSVIWWNEDLAERLHGKLFPLPLEVPAVRLSSIATLNSAPEAVEKVFSSACGFYWQTLETEEKINLPASDTPTDSETEVVSVIVFERMLRDPVAFHHALHIILTEGLDVCGVRLLYPQANALHSYIDNVPSSYNGEDGQTLPILALALRGTQAEQIWAEIAGPLDPQLARLTDQYSLNAIYGFKRGEPIIHWARKSGRLLQELSLWFGGRIPPSGTVNIGFQNSYSRSNQPRSASFTCQSASEKEITVFHSTDRCRPPALLTASTLGDVFLVVSPAVPSAAYGDVIDVCLHRGFTLHGVRRLRLSAKRAAMLSMSPTQVSVFCPNLPHSQTDAQPRMQHPQPRLHCFLLLLRKENAALHTSGLIQALMNVLAEQGLLGAIHARFSYICEVDPSLCFHVAPYTDNLLQGLGGSLHAEPDLSTVPLGMMSLRPFASDPEDEQVVVLTMSGRHTLRRAGYFLRKILRPVVKTLASSTGSVYEGFELLGLKWLPSLSRLQAKEITPYEVGDHPWKRSIEHLISNPALLCVLRRSNAFAALEHTIKQLAPTLGTEHPQLIASATPEIAFRQAALIFTDRDLVSDPESRSSLMYMPPAGINCRTEGTEDRRGRTESIFTYMLSGPPVLYTVLLLKPRIWSSALGKILFKVYQQKFILVGMKPVSLTTAMCSQILPEDVKKNEALCLAHCDYLTSAPCLVLCLQRQGAVLKLLDLLGPEDPGLGKAQDQFLWRAQYGTSAVQNGMYGSTSYQAAIRDIQTFFPEGLLFEESAVLQAEQIPRLTSDILVSSRSQRQTAKNPVRRMDLPTLDLPFTSALCQTTCLLFPAHMLRGASPPYIRTLEQLKSKEFHITAARLTGFDQSQGQLVADMYSPGNYSTAKVKLLTEGPCLVVAAQRDNAVACFPSLMNSADWRNVPAETLTEGVLYPQTESQANKMLSCFFDSLTPDSIHQILP
The following text describes a protein:
Function:
Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. ASH1 is necessary to repress HO in daughter cells to block mating-type switching through its binding to HO promoter 5'-YTGAT-3' sites. Also involved in pseudohyphal growth.
Miscellaneous:
MISCELLANEOUS: The ASH1 mRNA is transported to the daughter cell before cytokinesis where translation produces the protein to block mating-type switching. The ASH1 mRNA 3'-UTR and the mRNA localization machinery that are essential to restrict accumulation to the bud; MISCELLANEOUS: Present with 1800 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Note=Preferentially accumulates in daughter cell nuclei at the end of anaphase.
Sequence:
MSSLYIKTPLHALSAGPDSHANSSYYDNLLLPSFSNLSSNISRNNITTDNNINSASPRKYSFHSLNVSPILSPISLANEILGKKSNTAPASPHHMDYNPISSLTPGNSPEFNKASLSQISFTNPLNYGSGLGFSSNSQPRLPLLDRLSSVSLSKRPERPQQSLPSLRHLQLLPSPLLQENAARFPDTSKRTSNWKTDLTHWCKDTNYQDYVKIREEVAHFKPLSIPNLTNNQNNDSFNYGKELESTRSSKFHSPSKESFDRTKLIPSILEAKDQFKDLSNNAWSITPPVTPPMSPPTNRTMERTTLRGVEASFFEGKSSNNDSIFNPIISEKLVQEVKHQRQLRGNSFPMPNASHKKTNSFKALQIKKLLANRDILSNNSKSNVRKPSKNKISKQASNVFGNTARQLVMKLDNASYSSVSASSSPSPSTPTKSGKMRSRSSSPVRPKAYTPSPRSPNYHRFALDSPPQSPRRSSNSSITKKGSRRSSGSSPTRHTTRVCVSCHSSDSPCWRPSWSPRKQDQLCNSCGLRYKKTHTRCLNDLCRKIPTKGEINIMKSNGIDKEFVPERNCEIEGYRCLFCNYITETVEN
The following text describes a protein:
Function:
May be involved in iron transport and iron homeostasis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVSAYGLLDNLTRVVLGPTVGGYVDRHERMPGCKLMLRLQNCCISGSAAAALALLWPGSAALTNPALYWPLIWVLTVLGAASSAGSTGVQIAVEREAVKALCGDDAGALASTNATMRAIDLTALLLAPLVAGVLMTAAGPFVAAAAMSAYCGGAYIPEVFFLGAAFRAAPALMKPKATAATGPAADDDDDDAEGEHAGLLAASHQSPHQQQHSSKAGSSSGRLSRTASIQRPLITSHGSSASASAAHLGGRTSGDGEGDGVHGGADGGGEGEGEGKGEGEGLLLPAGGSGEGQGLLGQEQHQHQGLPTSTRPPTLRSTSARSLDVHTAEPVAAAAAGARGSRGLQGRTGGRGGGGDGASVASRARALLAGLGGAVAQYGDSWRVYVQQPLLLPCLALALIYMTVLSLGFLMTSFLKWTGLTEAEVSVYRGIGALTGLAATALFPPLSKWAGLRFCAAAGITYQMACLASGVLPVALTIMSQGGGKPSVGEVRVMVGGLVASRTGLWMYDLAVTQLIQQGVAEDHMGAVYGVQSSLQASFEMLSFVAGLLSPDPAHFHWLMLGSVCSVGTAACLVWVYVCTAPRRSSAAAAGAKGAGGTGFAVAGGGVAADGGGASAGGAQRYQVVPSGDDV
The following text describes a protein:
Function:
Anthrone oxygenase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC. The atrochrysone carboxyl ACP thioesterase tpcB then breaks the thioester bond and releases the atrochrysone carboxylic acid from tpcC. The decarboxylase tpcK converts atrochrysone carboxylic acid to atrochrysone which is further reduced into emodin anthrone. The next step is performed by the emodin anthrone oxygenase tpcL that catalyzes the oxidation of emodinanthrone to emodin. Emodin O-methyltransferase encoded by tpcA catalyzes methylation of the 8-hydroxy group of emodin to form questin. Ring cleavage of questin by questin oxidase tpcI leads to desmethylsulochrin via several intermediates including questin epoxide (By similarity). Another methylation step catalyzed by tpcM leads to the formation of sulochrin which is further converted to monomethylsulfochrin by tpcH. Finally, the tpcJ catalyzes the conversion of monomethylsulfochrin to trypacidin. Trypacidin is toxic for human pulmonary and bronchial epithelial cells by initiating the intracellular formation of nitric oxide (NO) and hydrogen peroxide (H(2)O(2)), thus triggering host necrotic cell death. The trypacidin pathway is also able to produce endocrocin via a distinct route from the endocrocin Enc pathway.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPQNASVIITQATAVITGSFLSGLMMGLSVVDIPVVLDTATQASQLLQHFTRLYDIGHKMMPSLAVTTCLLYGYTASSTRTTGGSGLPHIIAAVTTISMVPFTWLVMAPTNNALFRMHANPAAANLGEVRRLLVRWAQLHAVRSLFPLMGSVLGLRQILRE
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
DMSEKKQTVDLGLLEEDDEFEEFPAEDWTGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAELEKHGYKMET
The following text describes a protein:
Function:
Mevalonyl-coenzyme A hydratase; part of the siderophore biosynthetic pathway. Aspergillus fumigatus produces 4 types of siderophores, low-molecular-mass iron chelators, including excreted fusarinine C (FsC) and triacetylfusarinine C (TAFC) for iron uptake and intacellular ferricrocin (FC) for hyphal and hydroxyferricrocin (HFC) for conidial iron distribution and storage. TAFC consists of 3 N(2)-acetyl-N(5)-anhydromevalonyl-N(5)-hydroxyornithine residues cyclically linked by ester bonds; FC is a cyclic hexapeptide with the structure Gly-Ser-Gly-(N(5)-acetyl-N(5)-hydroxyornithine)x3. The biosynthesis of all four siderophores depends on the hydroxylation of ornithine, catalyzed by the monooxygenase sidA. Subsequently, the pathways for biosynthesis of extra- and intracellular siderophores split. For biosynthesis of extracellular siderophores, the transacylase sidF transfers anhydromevalonyl to N(5)-hydroxyornithine. The required anhydromevalonyl-CoA moiety is derived from mevalonate by CoA ligation and dehydration catalyzed by sidI and sidH respectively. The acetylation of N(5)-hydroxyornithine for FC biosynthesis involves the constitutively expressed sidL. FC is hydroxylated to HFC by an as yet uncharacterized enzyme during conidiation. Assembly of fusarinine C (FsC) and FC is catalyzed by two different nonribosomal peptide synthetases (NRPS), sidD and sidC respectively. Subsequently, sidG catalyzes N2-acetylation of FsC for forming TAFC. Both extra- and intracellular siderophores are crucial for growth during iron limitation and virulence.
Subcellular Localization:
Peroxisome. Note=Targeted to peroxisomes via its PTS1-type peroxisomal targeting signal and the corresponding receptor pexE.
Sequence:
MSTEAHPTVQGCLVSFPTPHILLLTLNRPEKRNCISLATSAEIQRLWTWFDTQPALYVAIITGTGESFCAGADLKEWNDLNARGITNEMTAPGLAGLPRRRGSKPIIAAVNGYCLGGGFEMVANCDIVVASENATFGLPEVQRGIAAVAGSLPRLVRVLGKQRAAEIALSGLSFSASQLERWGLVNRVVEHDQLLATAVEIATAISRNSPDSVRVTMEGLHYGWEMASVEEASSALVDQWYAKLMAGENFHEGVRAFVEKRKPQWRPSKL
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
MAIDGAYPPATLPAGDTKTESESAAITAAAHPLSALPTPVLLRSLLIATISSKPSLLIPSLSALSFLCKPRAGPLLNVDRNPILHFILKATFYRQFCAGETPDEVRSTIRQLAGMGFQGTIMTYAKESVFDAKTKMQTGLGVSTKMSGKQEVTEPTLARGEAFCPQIEAWRKETVETIELLGANDYLALKLAYLKSTPATIARHLQAASDVGFTLGLKLVRGAYIFSDERSLIHETKADTDAAYNGIAQGVLCRQLGAFGTEKPFPSVELFLASHNKESVMKAHALRLQRLKEGLPTVPVGFGQLHGISDEVSFRLLTLKNERNEPMVYKCSTWGRLSECLAYLVRRAVENRDAVGRTEDEYRALKREMARRSWYSLL
The following text describes a protein:
Function:
Involved in the biosynthesis of phylloquinone (vitamin K1). Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein. Note=Accumulates in discrete foci within the chloroplast.
Sequence:
MANHSRPHICQCLTRLASVKRNAVVTVYGNRKRTGREFVDGVLSLAAGLIRLGLRNGDVVSIAAFNSDLFLEWLLAVALVGGVVAPLNYRWSLKEAKMAMLLVEPVLLVTDETCVSWCIDVQNGDIPSLKWRVLMESTSTDFANELNQFLTTEMLKQRTLVPSLATYAWASDDAVVICFTSGTTGRPKGVTISHLAFITQSLAKIAIAGYGEDDVYLHTSPLVHIGGLSSAMAMLMVGACHVLLPKFDAKTALQVMEQNHITCFITVPAMMADLIRVNRTTKNGAENRGVRKILNGGGSLSSELLKEAVNIFPCARILSAYGMTEACSSLTFMTLHDPTQESFKVTYPLLNQPKQGTCVGKPAPHIELMVKLDEDSSRVGKILTRGPHTMLRYWGHQVAQENVETSESRSNEAWLDTGDIGAFDEFGNLWLIGRSNGRIKTGGENVYPEEVEAVLVEHPGIVSAVVIGVIDTRLGEMVVACVRLQEKWIWSDVENRKGSFQLSSETLKHHCRTQNLTGFKIPKRFVRWEKQFPLTTTGKVKRDEVRRQVLSHFQIMTSSL
The following text describes a protein:
Function:
Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
SSMASTSNNSVDQIRILKLVDGKHCENTLYRLQKGWTIRFMLGPDLASQKVTVYTNIPPSEQPFKRTVYYPLSWELLTKSGINSLDAYAPVKLSHSGAFQYYFTYNDKKAGSGYFIVDPTLCIGMDNHVLPLDAVCMQTLLPKSLGQFCDWKDRLLVAKESGYNVLHFTPIQKLGCSNSSYSVSDQMAVNPSFYSSVPVTFNDVENLVEEIRRDWEMLSVTDVVWNHTDKHSSWLKTYPESAYNLHNSPYLRPAYILDRAIFHLTLDIEKGKKYASYFPLSIIETEKDLESLKVILLKNVLPGLKLWEFYQVDVPKQVEHFTQAVKSFKQNGNVTKDVKIKIIQDPNFNRLQCSVDIQAAVEQFYAGSDCDLDRAVSSFVSTLEWLNRVKKETVMSDLFSAVNNIIAGVRYERLAADGPKVVLLNKQHPLTTMYFHHQFEDSTVDEEEQFVFGDTKNSKFIMAHNGWVMGANALENFAEYPGKVYFRRELVCWGDIVKLRYGSSPSDCPPLWERMKQYTEMTARIFHGIRIDNCHSTPIHVAEYMLDAARKIRPDVYVFAELFTGSEEVDNIFVNRLGLTSLIREALNAWDAHELGRLVYTYGGEAISSFIQPATQILQPSRAHALFYDITHDNESVIVKRSIRDVLPFSALVSMSCCAIGSNRGHDEMTPHHINVVNEKRKYRKWNSALNSGSEFVGIKSGMIQGKHLLNVLHQTMAMNGFTQIFVDQRTQDVVAVTRHNPQTHYSYILVGNTSFSDSKMKPVPPMLVEGSIMGIPLEAKPSETEQSTQDYLKGFTKDKQFINGIDNYNLVVDTDIAASNSTCCKILESEDKSSQTVHFTHFPPGSIVVLRVKVTETVNKSISDIRETIASLHNSNTHFDKLVSKLNLRTLNRVLFRCNEEEMSDGFGISAYQIPSWQKLCYCGIAGIAIPLKKISFSNDLGHPICSNLREGNWLMDYISSRLLKHPDTKDVGNLYADWFSILQKLPRYLIPMYFELIISLTYQKLLHACWKNMSSFVAEGSSFVKSLSLGTVALCGVVKGAALPRVHPDVPGVCSTSVDKDVQDCSSISAGLPHFSSGVMRCWGRDTFIAMHGLQLVTGQYDDARNIILSFAGCLRHGLIPNLLGEGKISRYNCRDAVWFWLQCIQDYCEAKGFELLGMPVARIFPEHDSEPTPVGAKSQPLSDIIQEAMQRHVDGISFRERNAGSGIDSNMSDEGFLVEVGVDKTTGFVFGGSKFNCGTWCDKMGESEKAGTRGVPATPRDGSAVELVGLCKSTVRWLEAAHNSGKYAYDGVFIKTCDGSVNKLTWAKWNEQIAKNFEKYFYVGDEDTSHLVHKRYIYKDTHGASYSWCDYQLRPNFPIAMVYAPELFDAEHAWKALQIIQDKLLGPLGVKTLDPDDMQYRGDYDNSNDSDDKSIAKGFNYHQGPEWLWPVGYFLRAKLYFAKKLGSKKLEETIRFIRSYTVNHQLHLENSQWCGLPELTNSNGSHCHDSCPIQAWSHATLLDLLYDMKDL