lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
RNA methyltransferase that methylates tRNAs. Methylates cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Required for short-term memory.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGRNQKQNFFAARKRQKRENGPKRTDRQAQPYEEIKRDNAFFIKYYQLQKICATDEEWTQFLASIRDNLPTTFRVTGFKDEAKALLSIIETQLFTEYVRAVAELHQKAPEDVERPLCLPWYPNGLAYQLHLTRKDIRRSEPLYRLHNFLIVETTAGGISRQEAVSMIPPIVLDVRPTDKVLDMCAAPGSKTAQLIEALHAAPEEHKIPPGFVLANDVDNNRCYMLVHQAKRLNSPCLLVTNHDSSVFPNLVTTKPDGSKAILKFDKILCDVPCSGDGTLRKNPDIWLKWNLAQAYNLHGIQYRIVRRGAEMLEVGGRLVYSTCSLNPIENEAVLQRIIKDADGALELVDAGHLVPGLKYKPGMTDWKLATKEVDQIFTRFEEVPESLHTIIRPGMFPLPADEMAKIGLEKCLRVLPHLQDSGGFFVAVLEKRRQLSFEKNDVVELVKLNETAKQPAAEPQVDADGKPIEEKSVPWGPQRKKRRLHGYKEDPYVFFGENDPDYQAIKEFYQLDESLSQRCLLTRCVTEKKKNIYYCSEPIRDLVLNNENNIKIINTGVKTFVRCENRHTVHPFRLAQEGLQTSNAFMGASRRIQVEREDLVMMLNCTDPTQPPSTHELKKETQERCKELGVGSCILKYVDQRFTLYTVGWRGTSSLRAYVQKDETIHILRLLGADLSKFETNKYEDARVAAAAAADAEVGKSAEAEADSSGDGDATESTFSGSGAIDVTVAAETTGTPMDTEVVATS
The following text describes a protein:
Function:
Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKDVKKVHKLRHDPLSKQIEESESAYQKPHKRVGKLRKKKAEMENDTGIDETESVIPSALSKKILDQIREQAIEVEVEDRKKEKQEKLLTFEQERIQSKLLSFNDFIDDDDDDEDADQDDNKRRSNGNDFDENDGFEQFSDTESQFGVGGEVEIDEEDERVLSMFMGGGGGDGQEQQFQTRFTLGDIIESKLKEHESRQVSSENAINPKVIDVYTKVGKLLETYTSGKIPRAFRILPNFTNWEDLLYLTRPDKWTPHSIRVATKLFCMSTNSKITQRFLSIVVLPRVRDNIAEYKKLNYHLYMALKKSLYRPAAFYKAILLPLAESGDCTLLEAKIIGSVVCKVSIPVLHSSVALMKLSQLTRYNGATSMFIRMLCDKKYALPYRVIDGLVDHFVMFDEEVRELPVLWHRALLSFVQRYKTDITKDQKEKLKIILRKHNHHIITAEIRRELFFSNSRGGVAPSNFTDDTSSMME
The following text describes a protein:
Function:
Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
Subcellular Localization:
Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MSCRYFFHPVVWRSFQVTGWCPRVAVPPIRPKLQCRCICKTYSSSSQKQDDTLLHKTEEKTETENHVSDADAHNLEINSTRTDNSKEAANTESNSDIETEYSPQVQSLLIDIQKKTPKTQLDTTYSPEDKETLLSVFNTASVQQLQQMRALKGLTADAIVTHRTLHGHYQTLGSLLAVQGVGRTTLKNVCERILNPASESDTEGGRGQVSSKAIYKPQLSQDSLQRVWSVMSIKAGLKHLSWAHLCRDGTLHDWDIQEVPCFLSGRFQAHEYLEAVSQIISTLPPADLYLLEQQTIKNDPSMAPLKLHFRSVEVLLYSLLNRDFSDTREHRVVSMSYAAVGRYFGVYVSGSRTSGRSMIHDIVKDSRESLNLRVAISQEMASDFLSRKDGILKDALCDCLMQALAFVEIVLDENHTGMKDS
The following text describes a protein:
Function:
Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.
Sequence:
MVRSALRLFLAVLLLAGAPWCAAADAVVQPKGSLVIIGGNLRPSNGPVWERIIQLAGGKGARIAVFASASGTPERSGKSLVERLNSYGAKAFFVPVAVKLSGSNYQTAADDRGLAEAVRNANGAFFAGGDQSRITRALRHEDGSNTRVLDALWDMYRRGGVIAGSSAGAAIMSSTMFGRPRTVLATLKLGVEEGEEITDGLGFVGDDVFVDQHLLVRGRFARMLPAMLKKGYKLGLGIDEDTAMVVLPNRDVEVIGYKGALVLDLSNAVVHEGAFNVTNVRVSYLDNGDHFNIVTRECTPSDDKADNKLDPSRPYYREPLFTADILGNSTVVDLMSKLIDSDQPDAIGITLGSPNGVQPDLGFEFRFTRTDDSVGYQSSSMESYSIYN
The following text describes a protein:
Function:
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development.
Subcellular Localization:
Nucleus.
Sequence:
MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPSHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ
The following text describes a protein:
Function:
Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Found associated with the RNA degradosome.
Sequence:
MRNTLIPILVAICLFITGVAILNIQLWYSAKAEYLAGARYAANNINHILEEASQATQTAVNIAGKECNLEEQYQLGTEAALKPHLRTIIILKQGIVWCTSLPGNRVLLSRIPVFPDSNLLLAPAIDTVNRLPILLYQNQFADTRILVTISDQHIRGALNVPLKGVRYVLRVADDIIGPTGDVMTLNGHYPYTEKVHSTKYHFTIIFNPPPLFSFYRLIDKGFGILIFILLIACAAAFLLDRYFNKSATPEEILRRAINNGEIVPFYQPVVNGREGTLRGVEVLARWKQPHGGYISPAAFIPLAEKSGLIVPLTQSLMNQVARQMNAIASKLPEGFHIGINFSASHIISPTFVDECLNFRDSFTRRDLNLVLEVTEREPLNVDESLVQRLNILHENGFVIALDDFGTGYSGLSYLHDLHIDYIKIDHSFVGRVNADPESTRILDCVLDLARKLSISIVAEGVETKEQLDYLNQNYITFQQGYYFYKPVTYIDLVKIILSKPKVKVVVE
The following text describes a protein:
Function:
Directs RNA polymerase II nuclear import.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRFYFYLQNQPISQRIQAALTTLHLYANLEPPKPQAKPKPTSTSTTTSSSSSSSASSKKSKKSKSKSKSKSDTKSKSRASQLAAQQEGRFQIVSTYRGVNLKGLDGQSAPSSVSNGVGRNKGATKDELFSLFDAVIDEEAKSSSKTSKSDDITCNSVKMIREKLVIDDGPDSEYVYDLYYTDDNQLDFGQTVVTGVQLEDEELVHDFFDEGSHEKYDDEDDSNDENNWRNDYPDEDPDKRHEDLFDEYKDEYRYGDISSDEDILNDYGDYRKRPTKGLDYFGGGRDPLDDLM
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVLGIETSCDETGIAIYDDEKGLLANQLYSQVKLHADYGGVVPELASRDHVRKTVPLIQAALKESGLTAKDIDAVAYTAGPGLVGALLVGATVGRSLAFAWDVPAIPVHHMEGHLLAPMLEDNPPEFPFVALLVSGGHTQLISVTGIGQYELLGESIDDAAGEAFDKTAKLLGLDYPGGPLLSKMAAQGTAGRFVFPRPMTDRPGLDFSFSGLKTFAANTIRDNGTDDQTRADIARAFEDAVVDTLMIKCKRALDQTGFKRLVMAGGVSANRTLRAKLAEMMKKRRGEVFYARPEFCTDNGAMIAYAGMVRFKAGATADLGVSVRPRWPLAELPAA
The following text describes a protein:
Function:
Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. EntF catalyzes the activation of L-serine via ATP-dependent PPi exchange reaction to form seryladenylate. Activated L-serine is loaded onto the peptidyl carrier domain via a thioester linkage to the phosphopanthetheine moiety, forming seryl-S-Ppant-EntF. EntF acts then as the sole catalyst for the formation of the three amide and three ester linkages found in enterobactin, using seryladenylate and 2,3-dihydroxybenzoate-S-Ppant-EntB (DHB-S-Ppant-EntB) as substrates, via the formation of a DHB-Ser-S-Ppant-EntF intermediate.
Subcellular Localization:
Cytoplasm. Note=Membrane-associated.
Sequence:
MSQHLPLVAAQPGIWMAEKLSELPSAWSVAHYVELTGEVDAPLLARAVVAGLAQADTLRMRFTEDNGEVWQWVDDALIFELPEIIDLRTNIDPHGTAQALMQADLQQDLRVDSGKPLVFHQLIQVADNRWYWYQRYHHLLVDGFSFPAITRQIANIYCALLRGEQTPASPFTPFADVVEEYQQYRESEAWQRDAAFWAEQRRQLPPPASLSPAPLAGRSASADILRLKLEFTDGEFRQLATQLSGVQRTDLALALAAFWLGRLCNRMDYAAGFIFMRRLGSAALTATGPVLNVLPLGIHIAAQETLPELATRLAAQLKKMRRHQRYDAEQIVRDSGRAAGDEPLFGPVLNIKVFDYQLDIPGVQAQTHTLATGPVNDLELALFPDEHGDLSIEILANKQHYDEPTLIQHAERLKMLIAQFAADPALLCGDVDIMLPGEYAQLAQINATQVEIPETTLSALVAEQAAKTPDAPALADARYQFSYREMREQVVALANLLREHGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWLPLDTGYPDDRLKMMLEDARPSLLITTDDQLPRFADVPDLTNLCYNAPLTPQGSAPLQLSQPHHTAYIIFTSGSTGRPKGVMVGQTAIVNRLLWMQNHYPLTGEDVVAQKTPCSFDVSVWEFFWPFIAGAKLVMAEPEAHRDPLAMQQFFAEYGVTTTHFVPSMLAAFVASLTPQTARQNCATLKQVFCSGEALPADLCREWQQLTGAPLHNLYGPTEAAVDVSWYPAFGEELAQVRGSSVPIGYPVWNTGLRILDAMMHPVPPGVAGDLYLTGIQLAQGYLGRPDLTASRFIADPFVPGERMYRTGDVARWLDNGAVEYLGRSDDQLKIRGQRIELGEIDRVMQALPDVEQAVTHACVINQAAATGGDARQLVGYLVSQSGLPLDTSALQAQLRETLPPHMAPVVLLQLPQLPLSANGKLDRKALPLPELKAQTPGRAPKAGSETIIAAAFASLLGCDVQDADADFFALGGHSLLAMKLAAQLSRQFARQVTPGQVMVASTVAKLATIIDGEEDSSRRMGFETILPLREGNGPTLFCFHPASGFAWQFSVLSRYLDPLWSIIGIQSPRPHGPMQTATNLDEVCEAHLATLLEQQPHGPYYLLGYSLGGTLAQGIAARLRARGEQVAFLGLLDTWPPETQNWQEKEANGLDPEVLAEINREREAFLAAQQGSTSTELFTTIEGNYADAVRLLTTAHSVPFDGKATLFVAERTLQEGMSPERAWSPWIAELDIYRQDCAHVDIISPGAFEKIGPIIRATLNR
The following text describes a protein:
Function:
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Sequence:
MSFLNKSLMLNFLNTFPKKGKFQHTYILTPKLNKSKLPERKTFKPTLQDGKYKVTASQKVPEHIKCPSYAKTGIVQNSNINYEIKDDKYIEKMKKACKLASECLKLCLENSKEGITTDIIDNMAYDFYIKNNAYPAGLNFHSFPKSICASPNEVVCHGIPNLRKLQRGDIITYDCTVFLDGVFGDCAGTVGIGEISERHKKLMDVSKECLYKAISICRDGQLFSEIGRIITEHANKNGFNVIKDFCGHFIGTHMHMYPLIEHHYPNSHNNHRMKKGQIFTIEPILSEGSINIYTWKDKWTVCTNDNSFCSQWEHTILVLDNYAEILT
The following text describes a protein:
Function:
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MASRERSPPSTASTTTMRPPTTALLIYPVTLLVGSLFSILSPTARGSRQSRPARPASLAPSITTDVNLSPPNPVNYFARKDNIFNLYFVKVGWIWTTLAFLSLLVSQPAYTAPSAHQPRRLVQAALRYSVATLVWYLMTQWFFGPPIIDRSFVITGGKCERVVAETSGNPAVAVAQAGSVSAGLEKLFTAAACKAAGGSWTGGHDVSGHVFMLVLATSMLVFEAVGATRAVSVGAEADKKVDGEVDGQSEEEQGDWMRTWSLRLVGAVVGLGWWMLFMTSIWFHTWLEKWSGLLIALGTVYVVYVLPLSVPSWRDIVGIPGV
The following text describes a protein:
Function:
Transcriptional repressor.
Subcellular Localization:
Nucleus.
Sequence:
MELPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSIYFKSLVLHDNLINLDTEMVNPSVFRQVLDFIYTGKLLSSSDQSSDQNFSALLTAASYLQLHDLAALCRKKLKRSGGKPLPGKPSTPGPISRLRLNNQRLSSSTPAGPNNHYPSTPSDADQQQPDEGLRDKLSDDEMFVGNSGKNGGNGSSNGNLSSGASAGEPDLGLDLSKKSPHSAGTATDALSPHSNSQESPQSASVSTTNSASLDDSSTTLPGVDTCTSENMDHSSSKTSEEPLNQSDGPPPSKKTRQGARKNEWPKKEVSGLKSEDHDRPLVNGVIVGPKDGRSSTIGGGNGSSFTTDQSFQCKDDEEVGENGQDHSEESGQSDGESAGGRGGAGGGHQSANYVYRQEGFEPAFGDNLYVCIPCGKGFPSSEQLNAHVETHTEDELYIKEEGGTFVKEEDEEEAEDLSAPVGPSSFGSETRPFKCTVCSKSYKDPATLRQHEKSHWLTRPFPCNICGKMFTQRGTMTRHMRSHLGLKPFACEECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHTSPS
The following text describes a protein:
Function:
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEIDSQAFAPEPKNAATILCADCGAPVDGTISGAFCYDCIKLKTDVTGGVPREAVLHMCRDCDRWLSPPNSWVVAAPESRELLALCLRKLRGLNKLRIIDASFIWTEPHSRRIKVKITVQSEINEGAILQQSFECEFTQNYHQCPDCAKSYTHNTWRACVQVRQKVPHKRTFLYLEQLILKHGAHKDCINIKEVHDGIDFFFAARNHATTFCDFLKAVVPVNIKKSEELISMDIHTSTRSFKFSFSCEIVPICKDDLVVLPIPLAKKAGNIAPLTICTRIGTSVQLLDPATLQTADIATDLYWRTPFRPLADVQELTEFIVLDIDPLGKQQGRNFLAEATVARASDMGVNDQTYYCRTHLGGILHVGDSVMGYLLSNTNFNSELFDILEGSNKYSAQIPDVMLVKKHYQRGKKSKSKRNWRLKRMNRDEGEMLPRKQDQEKMERDFEMFLQDVEEDVDLRQGMALYKAQQEAKQREAEAMETESEIDDDDDQGITIPMEQLLDDFDEMTMED
The following text describes a protein:
Function:
Transcription activator that binds sequence-specific DNA motifs. Involved in stress response. Plays a positive role in drought and salt stress tolerance through the modulation of abscisic acid-mediated signaling.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing NAC022 exhibit enhanced tolerance to drought stress and salt stress.
Subcellular Localization:
Nucleus.
Domain:
The NAC domain includes a DNA binding domain and a dimerization domain.
Sequence:
MAAAVAVAGPSMEVEQDLPGFRFHPTEEELLDFYLSRVVLGKKLHFNIIGTLNIYRHDPWDLPGMAKIGEREWYFFVPRDRKAGNGGRPNRTTERGFWKATGSDRAIRSSGDPKRVIGLKKTLVFYQGRAPRGTKTDWVMNEYRLPDYGAARAAAPPPKEDMVLCKIYRKATPLKELEQRASAMEEMQRGSSHGDYTATRASLVHDASASTGDDYFSSDDVHDSGFLIQSSSSSAAPSGSSSKNGGAGAPREAKKEEADVTVTVASATSLQLPAVSQLPSLQLPAMDWLQDPFLTQLRSPWQDQHCLSPYAHLLYY
The following text describes a protein:
Function:
Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MAPPQAPNRDRAGQEDEDRWEARGDRKARKPLVEKKRRARINESLQELRLLLAGTEVQAKLENAEVLELTVRRVQGALRGRARGEWRRGSRAGALTGHACHPRAGHVGSRSLGPVHEREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVSAELLNHLLESMPLREGSSFRDLLGDSLAGLPGGSGRSSWPPGGSPESPLSSPPGPGDDLCSDLEEIPEAELNRVPAEGPDLVPTSLGILTTARRAQSVWRPW
The following text describes a protein:
Function:
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity).
Subcellular Localization:
Nucleus matrix. Cytoplasm, cytoskeleton.
Sequence:
MSSGIALAPNCVSTFNDLKLGRKYGGIIYRISDDSKEIIVDSTLPAGCSFDEFTKCLPENECRYVVLDYQYKEEGAQKSKICFVAWCPDTANIKKKMMATSSKDSLRKACVGIQVEIQGTDASEVKDSCFYEKCTKI
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
SGLLMSIIRTLAASEDDHQRELEKERLEEAFTENDEKLDVLVSENYEELAVTIKQFGKIGDRISQSRQRIRKVKESLQQCKSLLYCRQDEMRKLWVEGVEHKKVLFLLDQIERVKEAPQKIEFYLSKKHYLHATELLIQTLSALEKELVPVEALNDVRNELISKKLAIHDTFISELHRQIYVNSVNAGMATKPDKQVAKIRNAAKLERRNSGEEDGRIDDDPLNLMTVLVESLSRLHRIPDMIEATKVKMDRHINMIVTHATVEVTDLAFDDENKDVDNPKRLLQLLNSLFKKFYCIVAAHKHVLKDLKTAITTSDLDTQLYDMEEIWAKIQSVLQNLLNDYLDADNAAVTSQLSGLSFTESAISMNTYLREQRAQKRTHSVEGKVCKANPRNITLIFGPLKKFIGKIEDEQDYPDGKMCALHEYITDYVQDIFIRQIQYELKKDFDSAMKVTDPLKVLADLATQQSLGNFKSLLHSAVVADKCLWDLYDLTCSLDSYHDHFLTMACSLMQEYKEMSIQSYRGVTQPESEDQQIVSASWVRQSEVTEVLTAMDNWKAVYSGRSTQQQLKPAQIKAVDVNFIKEAQFLMDRMEGYALAKNSLIEDTTDLKAIASLHESLEWMTGRLGTFVTSIQKYAPPDTLSMLKKLAQDYKNMSEICLLCLHIEMRLHCFYHLVPMFLNNSYDIRGLDSMEHDFQITKLKKDISSAEENLSVSLNEKKYRYVFEGLGHQMAAILMWGAKHIKRISPSGVKKMCRNVFALQQLLTNLTMSREPHLDMARQFYEMMYLMPDDLQAQVVEQGVRYSEEDYVEALNLLHRSKPGSGNENAQHARVQRLKGIVQEQT
The following text describes a protein:
Function:
Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEMKVLILVGVRLLFLPTTVCQSGMKHVSDNSALTAESFNGNEHSFEEFPLSDIEGWTGATTTIKAKCPEESITTLHVNNATMGYLRSSLSTKVIPAIYILVFVIGVPANIVTLWKLSSRTKSICLVIFHTNLAIADLLFCVTLPFKIAYHLNGNDWVFGEVMCRVTTVAFYGNMYCAILILTCMGINRYLATVHPFTYRKLPKRNFTLLMCGVVWVMVVLYMLPLAILKQEYHLVQPGITTCHDVHDTCESPLPFQFYYFVSLAFFGFLIPFVVSVFCYTTLIHKLNAQDRKWLRYIKAVLLILVIFTICFAPTNIILIIHHANYYYSNTDSLYFMYLIALCLGSLNSCLDPFLYFIMSKIVDQLTS
The following text describes a protein:
Function:
Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MTEQTYCDRLVQDTPFLTSLGRLSEQQVDRIILQLNRYYPQILSNKDAEKFRNPKLSLRVRLCDLLGHLQRSGERDCQEFYRALYIHAQPLHSCLPSRHALQNSDCTELDSGNASCELSDRGPVAFLTCLGLAAGLALLIYCCPPDPKVLPGARRVLGFSPVIIDRHVSRFLLAFLTDDLGGL
The following text describes a protein:
Function:
Role in flagellar biosynthesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Sequence:
MSSEFVISMAEKAVYVTLMISGPLLAIALLVGLIVSIFQATTQIQEQTLAFIPKIVAVLLALIFFGPWMLSTILSFTTELFSNLNRFAG
The following text describes a protein:
Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. Ig alpha is the major immunoglobulin class in body secretions.
Subcellular Localization:
[Isoform 1]: Secreted; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.
Sequence:
ASPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPVPSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSVRGPSGNREGPQY
The following text describes a protein:
Function:
Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Nucleus and/or cytoplasm.
Sequence:
MSGNETPDAGTVKSVSPSSGGSSLPARPTLRERDPNDIENRLRDQIEEDPTQILLYIELIKYYVGKQQVAEIREVFGQLHELFPLESFLWTIHLNWELEQEESGQVETLLAKCLSGELMNNDIYLWSTYLGYVRRKNNTVTGGEEARGTVLKAYELVMEKCAVFEPRSMQFWQDYLQFLEQWKPVSKWEEQSRVEILRKLYKRLLCLPVESLERYWEKYTQWEQEVNQLTARKFIGELSASYMNARSLYQEWSNLTKGLRRSLPTKLNQATQQNLPAPGQYDEYQLQIWTKWIQWELDNKLDLPEVVLRQRVEYVHRQAVQHMCFAPEIWYNYAMFVDENEHEKVLEIAVRCNPGSLSLTFKLAEYLELNNKIEALEERFQHCIARISMELQVMNDTTMDPDKILRQTRKLTFAYCVYMTTMKRVTGLSAARKVFSKCRKLKKDISYEIYVENAYMEYYNNSDVTTPCRVLEFGLKYFQDNGNYINKYLDFLILVKQDAQIKSLFESCIDKIYNLDQLKEIYKKVINYESKFGNLNNVYELERRFFEKFPEAEKIEVFTDRYQLQGENLLKRLEFPYLMDEYGIPVLSGYAVKRSLHSAGIVFDDNGSSKRQRQEQTEAVPMEIIELLKVLPKRQYFKTIVLDPHKLADFLSDKVTIPPCD
The following text describes a protein:
Function:
Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus.
Subcellular Localization:
Mitochondrion.
Sequence:
MKSFLLSRQAIHRISLLSSKTPTFCRNFSAITSTISHSDRHLRSYDEQTPFQNVEIPRPISSFNRYFHFTRESRLSESSAAIDDSNDQEEDDEDGTTNEFLSRFVWIMRGKVSEAYPDCDKKMIDGMLLLIVEKVVEEIERGGFNKVGSAPPSPSSEFSDDLWATIWEVSNTVLKDMEKERKKEKMKQYVQSPEVMEMCRFAGEIGIRGDLLRELRFKWAREKMDDAEFYESLEQQRDLDNSIRESETVDGEVEEEGFVPSDEVESRSISLPKRKGKLKYKIYGLELSDPKWVEMADKIHEAEEEADWREPKPVTGKCKLVMEKLESLQEGDDPSGLLAEWAELLEPNRVDWIALINQLREGNTHAYLKVRL
The following text describes a protein:
Function:
Functions as a ubiquitin-protein E3 ligase. Negatively regulates the transcriptional repressor hairy/hry by promoting its ubiquitination and subsequent degradation. Also directs the nuclear organization of the gypsy chromatin insulator. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them, and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may require the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may promote formation of nuclear insulator bodies by recruiting individual insulator complexes to the nuclear lamina.
Subcellular Localization:
Nucleus. Chromosome. Note=Colocalizes with the gypsy chromatin insulator complex on polytene chromosomes and to nuclear insulator bodies. Also localizes to the nuclear lamina.
Sequence:
MAEENPGALAANVPYLGVDELGASVIVEPGLEGSNAGGRTLPAAAIKFADLTESGSESGDNEAEEPVSAGPDNANAIGEPGTSASAAEENGTVERNSPPPNCAICLSRCRRKCFTDSCMHQFCFKCLCEWSKIKPECPLCKQPFRTIIHNVRTLDDYDRYPVQTTSPVPTENPSLRYHIVRRPRYTPLVQNQAVIVNDIEAAIAAGAAGEDVLSAAEVAAGRRSYSRFEPYRSELMNYYQHDQDASTSGSLSQLWRRYVYDRKLYALPVSDSVTGHFREWSARFYRNNPAQIHRLMPWIHRDIMCLLRNAAHSVNTVMTLMSDLLPMTSLLGPTFRRRLSPYLGERTSHFIHELFNFARSPYDINGYDHVVQYSARVAEEVEVDLLDMVETQSSNGDDLNLEVGDSDADAINAGFSPDWSPPRVRPSTSVIVTNPGATHSFSVTMASDGSELPGISIRRTTNVGSQTVAINLSMRRPAAVASEEPEVIEIDDGDAAANAEVAAINDGSNTSRRHAGATLPVTAHIELESSSSSGDEDECVFVLELKPPHMRTPEQVSLDSNSDSDVVFVNEQHEAAPDAIAENRSTQSPLDLASRDQGLFMGPSTSGAAANRGKNWKLVMAQTRRLDQLRTLRSIRSKKSRRSSMPARSDSGSSPSSCSSSSFHFSSSSDEDSSDSSTTNSEPPKKKSRKRVANNKRSKKESIGKRTSRKRKAKDQNMEMLEQQQISQKKPQRQPESSSDSPSSSDDESGGDSSESSGQPNTNNNKSSSDSDDDSAVNMQLSALRATLKAEATLEDRKPVKLELQLPDDDQAGPLHSRMTPSPREDNEPGCSAPKRRRSCSHSNQSSQSASLASSSTATSSSAPLSSFAWGAAGFSGDPLMRGHPAMEEHDIANSLIELSTLTQPVNIGLFNEHYNSAENSMGMLSNTLCDSPQTLAADDANLENYFDTDADPEASRERDAYSLEAAIDVVGESELQIAEDTATATEEQDEEDEEDEDQEEDDQEEEKAAEEEEEEEEDDDDSDNHDENDENQGLLPY
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAK
The following text describes a protein:
Function:
Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion outer membrane.
Sequence:
MTPKKKHLKTVVIVMCCVFFFLVKKEKMERGKYLALVGGGALLGSVSTFFLLRLLQSQNLTERDGLVGSSYSTFGSLRRGVSQCSKNVTADFNGVDGCTIARMKIDRVVNEDLLKDEIVSEQLTRNIQFFGFESQQKVTASYVVVIGLGGVGSHAASMLLRSGIGKLLLVDFDQVSLSSLNRHAVATRADVGISKAQCLEEHFSSIFPECQIVAKVLLYDSSTEEEILSGHPDFVLDCIDNIDTKVALLAACVRRGLKVLSATGAGARADPTRIRIADLRESTNDPLSRAVRHRLRKDYGIEGGIPVVFSLEKPKAKLLPFKGTSGEEENPSDYQIVPGFRVRIIPVLGTIPAIFGQFMASFVVTELAGVHVQTEPVVNFDMDHYHTLHQRLIEHEESLYGTSMEVQVDVEEVMYIVKELWHGRSAREQHVKDVGRGMWRSVNELMLVRWDRTKPASISNLILLKFKEVDEHESRTLEDIKENEPEFHSRVSAVLKRAELDFGL
The following text describes a protein:
Function:
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
Sequence:
MAKQSMKAREVKRVALADKYFAKRAELKAIISDVNATDEDRWNAVLKLQTLPRDSSPSRQRNRCRQTGRPHAFLRKFGLSRIKVREAAMRGEIPGLKKASW