lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Modulates blood feeding of female mosquitoes on vertebrate hosts. Inhibits collagen-induced platelet aggregation in the host via preventing collagen interaction with its three major ligands: glycoprotein VI, integrin alpha-2/beta-1 (ITGA2/ITGB1) and von Willebrand factor (VWF). Prevents collagen-mediated thrombus formation in the host. Binds to host collagens but not to laminin, vitronectin (VTN), fibronectin (FN1), von Willebrand factor (VWF) and fibrinogen. Influences cytokine production and populations of circulating leukocytes; (Microbial infection) Reduces replication of dengue virus type 2 at inoculation site and viremia levels on day 2 post-inoculation. Promotes production of pro-inflammatory cytokines, such as GM-CSF (CSF2), IFN-gamma (IFNG), IL5 and IL6, in the lymph nodes of mice infected with dengue virus type 2. Increases the number of circulating eosinophils in mice infected with dengue virus type 2. Decreases the number of circulating monocytes in mice infected with dengue virus type 2.
Miscellaneous:
MISCELLANEOUS: Protects mice from collagen- and epinephrine-induced thrombus formation in a murine model of lethal pulmonary thromboembolism.
Subcellular Localization:
Secreted.
Sequence:
MKPLVKLFLLFCLVGIVLSRPMPEDEEPVAEGGDDDASGESEGEEETTDDAGGDGGEEENEGEEHAGDKDAGGEDTGKEENTGHDDAGEEDAGEEDAGEEDAGEEDAGEEDAEKEEGEKEDAGDDAGSDDGEEDSTGGDEGEDNAEDSKGSEKNDPADTYRQVVALLDKDTKVDHIQSEYLRSALNNDLQSEVRVPVVEAIGRIGDYSKIQGCFKSMGKDVKKVISEEEKKFKSCMSKKKSEYQCSEDSFAAAKSKLSPITSKIKSCVSSKGR
The following text describes a protein:
Function:
Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAEQEASGLQVLLHTLQSSSDKESILTILKVLGDLLSVGTDRRIHYMISKGGSEALLQTLVDTARTAPPDYDILLPLFRLLAKVGLRDKKIGQKALELEALDVTLILARKNLSHGQNLLHCLWALRVFASSVSMGAMLGINGAMELLFKVITPYTRKRTQAIRAATEVLAALLKSKSNGRRAVNRGYVTSLLGLHQDWHSHDTANAYVQIRRGLLLCLRHIAALRSGREAFLAAQGMEILFSTTQNCLDDKSMEPVISVVLQILRQCYPKSPLPLVTASSAYAFPVPGRITTEPPHDLSEEDFEDDGDDEVDKDSDAEDGKVEDDDLETDVNKLSSKPGLDRPEEELMQYEAMCLELSYSFEELQSKLGDDLNSEKTNHHHIPAAASSKQHCYSKDQSSCGQEREYAVQTSLLCRVKMGRSTVHLGSKKNPGVNLYQNVQSSSLRRDSSESEIPDIQASLKADAWDIDAIFCPRMSASFSNSTRTREAVKVIDKLLQTHLKRVPFHDPYLYMAKARRTSSVVDFKMMAFPDVWGHCPPPTTQPMLERKCGVQRIRIFEDIRRLIQPSDVINKVVFSLDEPWPLQDNASNCLRFFSKFESGNLRKAIQVREFEYDLLVNADVNSTQHQQWFYFKVSGMQAAIPYHFNIINCEKPNSQFNYGMQPTLYSVKEALLGKPTWMRTGHEICYYKNHYRQSTAVAGGASGKCYYTLTFAVTFPHNEDVCYLAYHYPYTYTALMTHLDILEKSVNLKEVYFRQDVLCQTLGGNPCPLVTITAMPESNSDEHLEQLRHRPYQVITARVHPGESNASWVMKGTLEFLVSSDPVARLLRENFIFKIIPMLNPDGVINGNHRCSLSGEDLNRQWLSPIAHLQPTIYHAKGLLYHLSSIGRSPVVFCDFHGHSQKKNVFLYGCSIKETLWQAACTVGTSTILEEVNYRTLPKILDKLAPAFTMSSCSFLVEKSRASTARVVVWREMGVSRSYTMESSYCGCNQGPYQCTQRLLERTKNERAYPVDGLQGLQFGTRELEEMGAMFCLGLLILELKSASCSHQLLARAATLLSAEEEALDQHLQRLKSSNFLSKHIWFAYHFFAITNFFKMNLLLHVSQVCDT
The following text describes a protein:
Function:
Involved in early development of liver, exocrine pancreas and intestine, probably through cell cycle regulation. In liver, its function is partially redundant with leg1a function.
Subcellular Localization:
Secreted.
Sequence:
MSEMGFLRSVAAVLLLAVFSHAAVVTENGLPIQWRKAPSDLSHLPISNTGVQVNPWVYSQRMTMLKMVINATNAYMSSMGPGEQENPLWSLPLQLGWKLKSGRLADPTPDSSSTCGSEASDPVCISPLSFFGCVNYYLSVLPFLAAVETGVVSSGGHQMLIQVPAEVAQDYCSSYSDCSTKHPNTMAKWHLFFQSLRQVSQSKESDFNKKDSILGLMWAAEEESIQTASGACTERQKLYSSPEVSFQQSSVNLGAFISAAHYHASIERSGKFMSHLPSRVLQEADSPPNIADLSTEENHALYMLSWMNSINQLLGGSLVDLWRKAMCSAQAREKGQAFLDDLILDPKFPGSSLWSIICVMSTSC
The following text describes a protein:
Function:
Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAFTSALKLLKSSVSAIYHRLYVRAFLAEFISTFAILAFVNGLIAQAVLTDGEKGSGVAPKWGAFVAAMSGILIACGASGAHSNPAFSLLFALRGILPWAKLPVYWIAQYLGAFCGAAAVLGVYWDAIMFKGNGEFYITNEDPGLAAIFATYPMPYVSIAGCIIDQLFGSALLALCVAALTDPKNMRIPLPLVALYIGFLVLELAIGFSLNTGGSPNPARDLSPRILTYFAGWGIQVFRDWTWFWIPVVIPHIGVVIGYLIYFILIEAHWPTQ
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes at the cell tip and the barrier septum.
Sequence:
MTEELFSNSETCSLSDPLTSKTLSSIENPFDDPYILSEESEILTIKTDVLRPNILNRKSSFYPEADAPVRKSNLQVKKIFENQVLNCDGIKVAITIPDTSLIAGSLLHGNIWLSYEGAKNVETGVWIKEMFLDFYGILNFKGHSEPFYSISEKYSFCNLKTSALILSKAASASIGNKGLFLKCSCKVGFPFSFIVPLDIGPGTYHSSKLELLYYISSTLTLTSLDQNIRCTRCTIPKRVITSMHNNIAELYNPISCIKSLPYLSLEEAKTTLEVHTDRSLFFSGQIIDFTICYTHNHHRRIHNIKARLLETHIFHPNTQNHYGGYCMNQAEETFASCGYLKRYQKTKTKTRAKSTWKIANKSVYSNLAPTLKNTIHAQIKIPEFCRSVNLKDQLKIDYTLEVCFSAFFKPRILSIQIPITILHSWN
The following text describes a protein:
Function:
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Subcellular Localization:
Cytoplasm.
Sequence:
MRRFFYTHSRGVTEVVVGRGIPYDKYVERPVVLIEEGLENPLPNAPALALKGGEGVKSLEALSKVYVFLQEAEADRGSTLVAVGGGALLDLATFAAGTYMRGIGLVQVPTTLLAMVDAALGGKGAVDWGLVKNLVGVFYQPKAILCDLEWLRSLPPRVYRSAFAEVVKYGLALDEEFYSWLRQSTTALLNRGEDALEEAVYRSLKLKASVVEADEFEERGIRQVLNVGHTVGHALERVLGLLHGEAVSLGIAAELRLSAELGYLREKYVEETKSLLKAFELPTEAGLSSEQLAAAKGLIKYDKKRRRDYVYLPLVIRPGKWILERLRVEEVARAVEYVVPQGRTA
The following text describes a protein:
Function:
Plays an essential role in the initiation and regulation of chromosomal replication. ATP-DnaA binds to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex once per cell cycle. Binds the DnaA box (a 9 base pair repeat at the origin) and separates the double-stranded (ds)DNA. Forms a right-handed helical filament on oriC DNA; dsDNA binds to the exterior of the filament while single-stranded (ss)DNA is stabiized in the filament's interior. The ATP-DnaA-oriC complex binds and stabilizes one strand of the AT-rich DNA unwinding element (DUE), permitting loading of DNA polymerase. After initiation quickly degrades to an ADP-DnaA complex that is not apt for DNA replication. Binds acidic phospholipids.
Subcellular Localization:
Cytoplasm.
Domain:
Domain I is involved in oligomerization and binding regulators, domain II is flexibile and of varying length in different bacteria, domain III forms the AAA+ region, while domain IV binds dsDNA.
Sequence:
MEQFNAFKSLLKKHYEKTIGFHDKYIKDINRFVFKNNVLLILLENEFARNSLNDNSEIIHLAESLYEGIKSVNFVNEQDFFFNLAKLEENSRDTLYQNSGLSKNYTFQNFVISEGNKRAYEAGVRLAETQDNEFSPLFIYGETGLGKTHLLQAIGNEKFRNFPNARVKYVVSSDFAQEVVDAFYQRDKGIEKLKKNYENLDLVLIDDTQIFGRKEKTLEILFNIFNNLVLNKKQIVLVSDKAPDELIDIDARMISRFKSGLLLKIEKHNLSSLCEILTVKLKEKDPNIQITNEARHDAAQISGNDVRALNGIATKLLFFAKTSKQNLINTENLKEILFEEFEKFHKKSFDPYLLIENVCRRFNVPMDSVLSENRKAELVRVRDVCNYLLRQKYNMQFQQIGKIFKRSHSSVLMAVKRVAKMIENDSSLRDVITSLVI
The following text describes a protein:
Function:
Acts as a non-catalytic accessory component of a dynein complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSSNKYIINVKNADMPDFMQQDATECTIKAFEETNIERDIAMIIKKEFDKKYSPTWHCIVGKSFGSFVTHETKNFIYFNINKHSVLLFKAG
The following text describes a protein:
Function:
May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MICRMTWGLKGFPRVTAGKRPTRRAVGQNGDSERLPDPSSAGIGVGLVGFGIFFILFGMLLYFDSVLLAFGNILFLSGLVFIIGFRRTFTFFFQRQKMKGSSFFLGGVLIVLMRWPLLGMLLEAYGFITLFRSAWTHTAPSVPPASATAGLTEPFVSVQEFFPRGFRLFGLTGEYPHSEEGEQGAGQGGHLWMWSLGDRNCWHCWIKAASWACRRRSAWPPCSSWTIVLLIRNGSSCSSWRNWVTAAP
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSTKGATTGAGSRSTLPLKLSQLQNFCKRDPDGYKEDYDAQSRRLVSLVGILLLSPNADPSPSLVELIQFMAAVSSSSYKGEDSDRVADLLMDLLVGSSNGANNSNGGFSSSPSNNLTPILNSTLPVAALQLHRDIRKACVSALILMRNKGAVPPLRLLQLFFQLMAVVPDKNLRESLYHHIVNDIRNINKNGKRDEKLNRTIQSFFHRIVSASANESTPGGEDSPTDYAAKRAVQMTCDLYRRNVWNDERSVHILATAASSPNASVLSRALRFFLNIEEAMSLDKKASEDQKWEGNSTVNLHLHSKKTKARKREVEKQVKNRQKKQNERESHILAYREDRGVETSKKLFPAIELLNDPQGLAETLLKRVKSSGSNTYKFEVKMLMLNMVTRVVGNHELMLLPLYPLLQRYMGGHQRDVTAILAYSVQSCHSYVPPEEIYGILKTIAHNFITERCSGEQMAVGINAVRAICARVPSVLSGEDEEECTGEGDDKVAASATWDVEAFVRDLAGYAKHNDRSVSIAGRGWVNFIREVYPSLLQGKDRGLVGAGLHRAGEKPLKYGEVRAAAGVEGADLLAAYEASKKAVKENANESEEDGSEGDESGEWVEVTNGDESEIEIDDEEEDEASDEDAPDLVLLGDKETINGDEGNDSKEMAKDLSKLSPKERAKLQQEVSSTRIFTTAEFAKMQKLVERQQQARRDPRMAAKLKRAIAKGEEFADLSDDDSDIDSDDDDIHISGAVNPTDIMADAKRKRMSKKEKLQKVLEGREKWEAKGRAGGSTNVEKKRKKNFAMSKFSFATRQKMGEKGTAKQGRKKKMIEGGRDSKKRRRKV
The following text describes a protein:
Function:
Component of the GPI transamidase complex. Involved in transfer of GPI to proteins.
Miscellaneous:
MISCELLANEOUS: Present with 1680 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MILTLAYFMLGTLLLGVFAEDTVSQIGINDSLWYPYDEALVLKPLPNNDLLLSFAFQLQSEPFDPAVSSMSYDAYEHYTTFPRAIPPLLESTATRQFHLRFTRGFWDALSWGQLPHAGKEAGASGVELWSQVQAMDQEQAFHNWKKLSNSLSGLFCSSLNFIDESRTTFPRRSYASDIGAPLFNSTEKLYLMRASLPNEPICTENLTPFIKLLPTRGKSGLTSLLDGHKLFDSLWNSISLDIATICSEDEDALCHYEMDARIEMVTHVPSALARGERPIPKPLDGNTLRCDTDKPFDSYQCFPLPEPSQTHFKLSQLFARPINNGNLFANRPTRICAEVDRSTWTAFLSVDDTIFSTHDNCFDLSNDQNEGGSGYDFILESTDTTKVTPIVPVPIHVSRSLTGNGQDRGGMRIVFHNDNDTPVKLIYFESLPWFMRVYLSSLQITSTTSPQLQENDIILDKYYLQAADRKRPGHLEFTMLIPANTDIVMTYQFDKALLQFAEYPPDANHGFEIDAAVITVLSLESSSSLYEMRTSTLLLSLSTPDFSMPYNVIILTSTIMGLIFGMLYNLMVKRMVTVEEADKITLQSGLKYKLLKLKEKFLGKKKTKTD
The following text describes a protein:
Function:
Synthesizes selenophosphate from selenide and ATP.
Sequence:
MERGNEKIKLTELVKLHGUACKLPSTELEFLVKGIVTDDDLLDKNILVGLGDDASIIKRNGLVIAKTVDVFTPIVDDPYIQGKIAACNSTSDIYAMGLLDIVGVLAIVGIPEKLPIHVVREMLKGFQDFCRENKTTIVGGHTILNPWPLIGGAVTGVGREEEVLTKAGVKVGDVLILTKPLGTQTAMALSRIPEEFKDLISITEEERDYIINKAIEIMTTSNRYALKALRKAEERVGDKIANALTDITGFGILGHSNEMAKNSNVLIEINLLPCIKRTPELSRLFGHALLDGYGAETAGGLLISAKEEYKDNLIDELEKAKCYAFEVGRVVKKGEGKAVLSKDVKVIEI
The following text describes a protein:
Function:
Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE3 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit. Associates with KCNC4/Kv3.4 alpha subunit to form the subthreshold Kv channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells (By similarity). Association with KCNQ1/KCLQT1 alpha subunit may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Perikaryon. Cell projection, dendrite. Membrane raft. Note=Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal neurons.
Sequence:
METSNGTETWYMSLHAVLKALNTTLHSHLLCRPGPGPGPDNQTEDRRASLPGRNDNSYMYILFVMFLFAVTVGSLILGYTRSRKVDKRSDPYHVYIKNRVSMI
The following text describes a protein:
Function:
Probably part of the binding-protein-dependent transport system YcjNOP.
Subcellular Localization:
Periplasm.
Sequence:
MIKSKIVLLSALVSCALISGCKEENKTNVSIEFMHSSVEQERQAVISKLIARFEKENPGITVKQVPVEEDAYNTKVITLSRSGSLPEVIETSHDYAKVMDKEQLIDRKAVATVISNVGEGAFYDGVLRIVRTEDGSAWTGVPVSAWIGGIWYRKDVLAKAGLEEPKNWQQLLDVAQKLNDPANKKYGIALPTAESVLTEQSFSQFALSNQANVFNAEGKITLDTPEMMQALTYYRDLTANTMPGSNDIMEVKDAFMNGTAPMAIYSTYILPAVIKEGDPKNVGFVVPTEKNSAVYGMLTSLTITAGQKTEETEAAEKFVTFMEQADNIADWVMMSPGAALPVNKAVVTTATWKDNDVIKALGELPNQLIGELPNIQVFGAVGDKNFTRMGDVTGSGVVSSMVHNVTVGKADLSTTLQASQKKLDELIEQH
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKKEINFLGKRVRRVFMILSLLFVIIGMYFFFTKGLNYSIDFQSGSVIYYKLSSPLNSNQIANLRDIARSFYSKSTIQTGSNGKEVWIRTKFLEENELKRLTSEVEKVIVKYEGREITTIEPTISRELREKAILAAVLAIIVMLVYITVRFRFDFAISAIINEAFVLLATISIFAISQWEVSPSFIAAILTLLGYAINDNIIVFDRIRENSKKYPKEDFTIIANRSINQTLARTLYTVITTLLAITPLLIWGGVVLRPFILAIYLGIIIGTYSTIYIASAILCEWRELQK
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit; Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MDLFYWRFDIESSVRWITENNFQRVALQFCEDLYKDSIKIYLEIKNKLPPSTELAIIADNKYNSCCLDEINAEHLRSDCLIHYGEACFSPNSYKTKFPVKYVFPKKSLNLSTFGENLKKFMTKNPEEMIATTRYVVVYGLAYHYLRDEITSCFKELNVLFHCPIIEEYSADDGDNQTATDEHKFHQHFVGRNFKFSAEDRKTIKIIYIGGEDSFITSLLMRLNECSCAIYKVEEDSFVDGWSCNKLLKKRYYMVEKARDANFIGIIVSTFSNFSTQVIEKLKTSIRQVGKRYRIYSPGSLNPAKLANVSEFDAFVYVSCPLNAFIDCSDYLQPIVTPYEMLLACKRTFAWTGDYLLDLGELARKVNADDDDTLVGDVTMDVSLITGRTRKIGLGEYEQQQQQQRHRNNKNNNKRSCCHGDESCCHSDEDGDVKEIACLGSRSIAAQSSYGEHWSARSWRGLEMKLGETDVVAVVDGCTGIPTSYQHECKQ
The following text describes a protein:
Function:
Molecular chaperone. Has ATPase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MKGQETRGFQSEVKQLLHLMIHSLYSNKEIFLRELISNASDAADKLRFRALSNPDLYEGDGELRVRVSFDKDKRTLTIADNGVGMNRDEVIDHLGTIAKSGTKSFLESMGSDQAKDSQLIGQFGVGFYSAFIVADKVTVRTRAAGDKPENGVFWESAGEGEYTVADITKNDRGTEITLHLREGEDEFLDDWRVRSIISKYSDHIALPVEIEKREEKDGETVISWEKINKAQALWTRNKSEIKDDEYNEFYKHIAHDFTDPLTWSHNRVEGKQEYTSLLYIPSQAPWDLWNRDHKHGLKLYVQRVFIMDDAEQFMPNYLRFVRGLIDSNDLPLNVSREILQDSTVTRNLRSALTKRVLQMLEKLAKDDAEKYQTFWKQFGLVLKEGPAEDHANQEAIAKLLRFASTHTDSSAQTVSLEDYVSRMKEGQEKIYYITADSYAAAKNSPHLELLRKKGIEVLLLSDRIDEWMMNYLTEFDGKAFQSVAKADESIEKLADEVDENAKEAEKALEPFVERVKTLLGDRVKDVRLTHRLTDTPAIVTTDADEMSTQMAKLFAAAGQSVPEVKYIFELNPDHVLVKRTADTKDEAQFKEWVELLLDQALFAERGTLEDPNQFIRRMNQLLVS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MFPPARGKELLSFEDVAMYFTREEWGHLNWGQKDLYRDVMLENYRNMVLLGFQFPKPEMICQLENWDEQWILDLPRTGNRKASGSACPGSEARHKMKKLTPKQKFSEDLESYKISVVMQESAEKLSEKLHKCKEFVDSCRLTFPTSGDEYSRGFLQNLNLIQDQNAQTRWKQGRYDEDGKPFNQRSLLLGHERILTRAKSYECSECGKVIRRKAWFDQHQRIHFLENPFECKVCGQAFRQRSALTVHKQCHLQNKPYRCHDCGKCFRQLAYLVEHKRIHTKEKPYKCSKCEKTFSQNSTLIRHQVIHSGEKRHKCLECGKAFGRHSTLLCHQQIHSKPNTHKCSECGQSFGRNVDLIQHQRIHTKEEFFQCGECGKTFSFKRNLFRHQVIHTGSQPYQCVICGKSFKWHTSFIKHQGTHKGQIST
The following text describes a protein:
Function:
Acts as a regulator of RIGI and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to RIGI and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on RIG-I signaling may involve the following mechanisms: competition with RIGI for binding to the viral RNA, binding to RIGI and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by RIGI and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
Subcellular Localization:
Cytoplasm.
Domain:
The RLR CTR domain is capable of inhibiting dimerization and signaling of RIGI and also facilitates binding of dsRNA.
Sequence:
MELRPYQWEVILPALEGKNIIIWLPTGAGKTRAAAFVAKRHLETVDRGKVVVLVNRVHLVSQHAEEFRRMLDKHWTVTTLSGDMGSRAGFGLMARSHDLLICTAELLQLALNSSEEDEHVELREFSLIVVDECHHTHKDTVYNTILSRYLEQKLKKAEPLPQVLGLTASPGTGGATKLQGAIDHILQLCANLDTCHIMSPKNCYSQLLMHNPKPCKQYDLCQRRAQDPFGDLIKKLMNQIHQQLEMPDLKQQFGTQMYEQQVVQLCKDAAEAGLQEQRVYALHLRRYNDALFIHDTVRARDALDMLQDFYDRERTTKTQMVRAESWLLKLFDDHKNVLGQLAARGPENPKLEMLERILLKQFGSPGHTRGIIFTRTRQTASSLLLWLRQQPCLQTVGIKPQMLIGAGNTSQSTHMTQKDQQEVIQEFRDGILSLLVATSVAEEGLDIAQCNVVVRYGLLTNEISMVQARGRARAGQSVYSFLATEGSREMKRELTNEALEVLMEKAVAAVQKMDPDEFKAKIRDLQQASLVKRAARAAHREIQQGQFLPEHVQLLCINCMVAVGYGSDLRKVEGTHHVNVNPNFSVYYTTSQNPVVINKVFKDWRPGGTIRCSNCGEVWGFQMIYKSVTLPVLKIGSILLETPRGKIQAKKWSRVPFSIPVFDILQDCTQSLSELSLD
The following text describes a protein:
Function:
RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRERAQRAPASFAAGDVTAAARPPPSSRSPRLGGAQARPGRVRSSEVGGPSAQPRPWSRPEPPRLPAVGSRPIPPVCPCRAWSVWRDVGRGVPSVRRRYGNGRKGRCGAARWPEMTLRFARRRWSRAGAMSAGGGGQRDAGTAGGRRSKWDQPGPAPAFLLSGAAPLPGRPFPGGGDGGTAVGVSESSAAPSGALDAAAAVAAKINAMLMAKGKLKPAPNTADKLQALGKGPATNKSKDDLVVAEVEINDVPLTCRNLLTRGQTQDEISRLSGAAVSTRGRFMTAEEKAKVGPGDRPLYLHVQGQTRELVDRAVNRIKEIITNGVVKAATGSSPTFNGATVTVYHQPAPITQMSPAVGQKPPFQSGMHYVQDKLFVGLEHAVPTFNVKEKVEGPGCSYLQHIQIETGAKVFLRGKGSGCIEPASGREAFEPMYIYISHPKPEGLAAAKKLCENLLQTVHAEYSRFVNQITTAVPLAGFAQPAAINSVPSQPSYYPSNGYQSGYPVVPPPQQPVQPPYGVPGIVPPAVPMAPGVLTTLPTGVPPVPTQYPISQVQPPASTGQSPLSAPFLPAAAPVKTTLPAGTQPQVQPHPQGQKRRFTEELPDERESGLLGYQHGPIHMTNLGTGFSSQSEIDGAGSKPASSSGKERERDRQLMPPPAFPVTGMKSESEERNGVGSLPGSHDHQAKKMKTSEKGFGLVAYAGDSSDEEEEHGGHKNASTFSQGWSLGYQYPSSQQRAKQQMPFWMAP
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MDDIQVKVFIPEKSKAVTPKRDRKLEHQQRKLKQEQKKQKYFDKIHSNRQTEQQPQHQIENNEVQQINQTNDHKQSQRKPRVPMKQLVIHQKPQSVTLPSINVEQEGEVFTEQYFEDLQIHPNVKLGLKSSEYIKMTKIQQLAIPIVDTKANTFIKSETGSGKTLAYMVPLISHLMSAEVRITREQGTYILIVCPTRELSLQCVDAALKVGKKCPNIVVGALVGGENANHEKARLRKGVTIVVGTPGRILYHIQNTQSFKYLNIHTLVFEECDRILDMGFQKDIEQLIELFSDKIDIPSCQKIMVSAHVNQNICQIKGLEITPKNYKFVGFSKEFIKGTKNKDIQINDENQQCDWLGEGDPTWQIPSTLKQYYTLIQEHQKLAFLFAYIRTQIGKKTIIFVSTCDEVEFYSFLFQQVQFNNPFKKDQQQHKQAFITQEVYKLHGNIEQQQRSKTYFNFKKSKYQEGCVLISTSVASRGLDFPDVTNILVFDPPDSYDDYVNKVGRTARINKNGISLMVLFENLESQQFIEETQSHLAAPLNLIESAEYFKAFQYYLFETKKIHDKMPDKFLALMIKQKIKQDKDYQLQSRRAYVSFLRAYGRLKSFKIKTLNLHNLSKSFALEKAFSEDTKDERYQKDLKFINREKFRQREDQANETRWDRERKKRRVMSQAELSKMEFM
The following text describes a protein:
Function:
Methionyl-tRNA formyltransferase that formylates methionyl-tRNA in mitochondria and is crucial for translation initiation.
Subcellular Localization:
Mitochondrion.
Sequence:
MNFVKQFRKYTTIKQPPYKILFFGSDCFSLVTLKKLHNAYINGSLITKLEVMCLPHSKIRKSVVHEFATNHQIPIYYWGNFEFGGEFDLGVVVSFGKMMPQRIIDSFSLGMLNVHGSLLPQLRGSSPVSRAIQGGITSTGVSIFQIKSDGFDHGKILSYSSPVVIDDHVNSDELTQKLAYIGADLCLEVLWNFPERIANAKEQDRKLISYAPKINVQETFINWESMTPETILKNFRAFGYQKDYFLRCEYNGQMIKFLQLSSCTVEQTAFVSGNCPPGMVSYHKPSKTLLVKCCSGHVACTKLLYGKILSSADFYNGFWQKVKKQGKNVQFLSNKY
The following text describes a protein:
Function:
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Sequence:
NYHVLLGQNNLSEDVQHRLVSQSFRHPDYKPFLMRNHTRKPKDYSNDLMLLHLSEPADITDGVKVIDLPTKEPKVGSTCLVSGWGSTNPSEWEFPDDLQCVNIHLLSNEKCIKAYKEKVTDLMLCAGELEGGKDTCRGDSGGPLICDGVLQGITSWGSVPCGEPNKPGIYTKLIKFTSWIKEVMKENP
The following text describes a protein:
Function:
Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MKETIAYLGMGMWGFSLANLLANNGHRVVGWARNPALIEQLSVQRRHPAAPHISIPQNLSFTSHMEEALDGATMIVEGVTSAGMRPVLTQLKALTELRVPLVITSKGIEQNTGLLLSEIALEIFGRPAAQHLGYLSGPSIASEVLRGCPCSVVISAYNPDTLKQIHRAFLTPTFRVYPNSDLKGVALGGALKNVIAIACGISDGFRFGDNAKSGLVTRGLHEIRKFATIMGCRPDTLNGLAGLGDLCTTSFSAFSRNTLFGKLLAEGLTPEQAKTKIGMVVEGVYTALSAHQIATHHRIDMPITTSVYRVLYENLDIQEGIAQLLQRDTKEEYL
The following text describes a protein:
Function:
In the process of mRNA degradation, may play a role in mRNA decapping.
Subcellular Localization:
Cytoplasm, P-body. Note=Processing bodies (PB).
Sequence:
MGPTDQDWIGCAVSIACDEVLGVFQGLIKQISAEEITIVRAFRNGVPLRKQNAEVVLKCTDIRSIDLIEPAKQDLDGHTAPPPVVNKPTPVKLPHFSNILGKQQQLQLQQQQQQLQLQQQQKQQFQEQEREQDLPSTPRSRANDNGRVAAGGASSSSGPRGNFNSALSDKMHQLKLIETNGSNGTLRTPQTSRASSAQQQPQISTTPNSVAAFFGNMIPPKVEVKLGSYVSNTRESYCSSSGDSGEATGLSLGSSKPIDIVSNGDGFYKQTAASSYGNTNGNVRRNGNANNNGNGTGNGSYTNGNGNGNGKNKRNRVRRESSMRQQQVQLTFGSEADDPLIHEDFDFEGNLALFDKQAIWDDIESTTQKPDVVRHIVNNHHHKPEQKYRHDENILASKPLQLRQIESMFGGSQDFVTDDGLIIPTIPAYVRNKIEISADKAGLSLQRQIDILARGASDLAITLLGGARRLTPANNHQWPKIAIICDGGKNMRTINIGAATGRQLASHGLTVLLYVEQAKLLEQNSSSPEISLFKATDNVIVHSVDALPTPDLVILSTNTANLSDAIRKWLSVNRASVLAIDPPPCGINEVAIKYSILPILPLNGISTATTSSSSSAAATPTPIASTSAAASATKSAASTNNCGKLYLCNLGIPDKFYRDCGIKYKSPYGHKYVIPIHSKD
The following text describes a protein:
Function:
Polynucleotide 5'-kinase involved in rRNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEINKNDNNNNINNNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNQNNNQKNNYRNYKPIKTGTLIQHQILQQTLSNFQTKNKVFQLGSDKLILIFKENETIYFHGTIQARSIIGSVEVYGYTITPQSTTYYPIYSPFCSPTLSITSNNSNNKLYTLKEIIENQLIKIPELVKNKLKENEKQIEIDEPTLAISSIIVLKILDDHCENPKMFTKKKIEIIDSFKLLKGFYPLYQPDFNTQLLTIPNEWLNLINTQFLYNDHCNNNGLSILTCGERNVGKSTFNRILINKLLKKYTHIIFIETDTGQTEFTPSGIMSIDIINSPLLGPPFTHCKNNPLKSYFFGDTSPKNNPEYFLNLSFQLIDCCNLIKQQYPNIPIILNTNGWLKSLGLHLTQEIIKYFKPTSIVQLINNNNNNNNNNNNNNNNNNNNNNNNNNLNDNLNNFINRFDSTVTFSQDCINQLFEDCDDDNDDNKNLKTTIITKLYSINSINNFSQSIYKPIFNLGSSEIRNLMFKSYFKLESKGSLSHQSPYQVSWKELKVKILTNNVPPSQTMYALNASLVGICIDEDPEKNYKYISYKVGNNLPTIINQSPLISQCIGLGLIRSIDMVNGYYYIITPIDPSLLEISNTILKGSIEIPQTLTISVSSKGKILVPYLQLDVLSSYGTGSDVMNRPSFFDD
The following text describes a protein:
Function:
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein. Membrane, coated pit.
Sequence:
MFTQGVQKIKLSKHFHDTCIAIGECKSREAEEKIVSQWMQEVKKNLDKKKINISDLYENVISLVHLTLLGYNTNFGQIHAVNLTQDVQMMTKALGYLACSALFDSKSDLIVLIVNSTQRDLSSNHPTSMALALTAIAQLVTPELIQPVIGFVGQCLNHSVPIIRQKAIMCVHSFIEKDASTVVDLFPELCRLLSDPDLSIVNSVIVTFTTLLKHHLNIRQICELLPDITRAAQMIQTNNTKIEYSFQNVSAPFVLINILRLIRRIALDTPGIQDQIEPILAQTISSVTLETPASAALLYEAIKTAIALDITEIPQLKGAISLFMSAREQNYKYIGLSLLTTIPDFASEFQSTIIDCLEHPDPSIRLITLNLLHNMASEDNAQIIVINMLKFFQRTKNEIIRRDLSDRITDIASKFSPSPIWFAKTMEQLFAIGGDLVRPEVAFQVMKIIDEECDEEMRRSIVNLYLDVAQSARRLSDVFVTVISHVIGNYAELSDEYDLSFIILLLCDLADGYDNPREWVLNAILKLLPKIEEVPQEVLDVFENYKQSRSIIVQNICYEALQLLNFRESLNIVLSMNEEEDPQLSFLNDFVNEAIANGGRQYIPIDDRDTDIIVTNKPTLIYTQYPHNTPGNVYSADGVNSGPVSTQVEEDTTTLNVSGVAAVWGNEGLVEQAPEQPQQQAPTYTQNYEEPMDTYHQKKQSMFAKLAVAGKKNQNAEQEKKDKLAASIFKGAKPIAKKPINKQAPAAAAAPVSAPVVNVQLTPEQIQNIEKATAELQTPPPQKIAEFSASGISPQPVYGDDYIKVIACANQGKILVAVMNATSTPIGDFKLSIEGPDVLNKEIVSQPETINCIPPQNAVTMLGIYSFPKTMKGFPQFKFTANIEYFGKKLNVNLPANLLSFIAPQQATTAEFGAAWKSGGSEIVYTLPKSEGMTLDDISRLMNTVVGVKTVQRIGQEEIFMGLLVSTPFKILIHVKFGAQKVDIKVLTKAQPLTASLVNDLKTVFA