lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end (By similarity). Cooperates with dynein to control the spindle elongation rate, but is dispensable for mitosis.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MITGLSIHNQINKKNEPVKKEQNIQAFVRVRPFSVYELNQGVTTVPIRVSDSSKEVLCEYKGTTRQYKFDHVFDQDSIQSEVFNIAVKPICDEVLLGFNGTIFVYGQTGTGKTHTMEGKHGSNEDMGIIPRTINYLFQCLEQSGADYNIRASHLEIYKEEIFDLLACNGNENLNKPLGMFDTQKGFKIPELEEIVVNDRQSILNVLAKSCKRRQTAETQYNKQSSRSHCIFSITVHVKETSVGGEDLIKIGKLNLVDLAGSENAEKSGNNDRLREAALINKSLLTLGKVITDLTNNEKHIPYRSSQLTKILQDSLGGKTKTSIIATVSPSLVNLEETINTLEYALKAKNIKNTPQINQRMSKNSLLKEQSSEIAHLKQLLQAAYDKNGVYLTIDVYEQMKRELEEKCSQQSITEHKMEAQRHEISSMRKSFDEQTMLFEEAMNELESSKKQQQEKQKFIDQFISQDTMLRSNLGSAVQDLSKLHEKLDTMKSTERENQKSIIDSKSILSKRLTDLNQMLVSKLQMGQNELLESLSVQLKVVHDQQTKSNQLIGKRINNLSQLIDSSVLQIQQLNNDDKQQTQPLLKLNKESNDLFMKLDKTIQQLSDQIKIILSDFSLPFFNSNNNNSNNGDEIIDDSLINNCFKLINDHVNKSDLIVSQQNKLIQEFSESMSQWMLHQSQYIIEQRDYQKQLKEKQILNNTQWEKKLLSKLGQVIQQFSKNFTDSTSVYYDTMDNNLQHFEKQFNSINNHSRQQVESLSNNLQQSSTLSHQFESTVKSVLNDHHANNKKVDPKLIESIEKAKKRINQLTDGCIDLSQRQRQCTNQFNEAFTDFTFGIQSQKDILDRVIIEKNQVHEILPLIEKSKSTFKENIDTLIHSLDSRKSIIQSSTNECSNQLNSLISSIPSYLDSAIKVTSKSGETPSKKHFDIPSPISTSSSSSSSSSISSIHSNAGGKENNHQSINNSIKSNNFDGSKSINCDNMKIDTPQKSSTIPITPKSLKLNLNSTPKSVSKNLKSSQQQQPLIVPSSNQLTLSAKKLSNKEYQRLQQQQQQQQQEQQQQQSAKKKKLAIEKQLMITTSPTLSLVNESPFSSPKLSKQKILQDQIQPPQPPSILSQLNSTPISFLQPQQPQQQPPSFFNNLNGSFNRGNNSIDFSLLDDDSDSDNSDDDVRSLLSSNKKSSRASKNAVVSKKVGLTPSRKLKGVNSSANQSLNVKKSKPILTSLSKKQNISTPIIHSSKPSIFGGGSTISSKLKSLKQQTPLK
The following text describes a protein:
Function:
Essential for development and viability. Required for ovary development and oogenesis, and is essential for the development of the indirect flight muscles. May act as a negative regulator of the Notch signaling pathway in certain tissues, such as the muscle precursors and ovaries. May function as a linker protein between the actin and microtubule cytoskeletons.
Miscellaneous:
MISCELLANEOUS: Named 'Picked eggs' based upon the mutant ovary phenotype.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=In the cytoskeleton associates with both actin and the microtubules.
Sequence:
MAMLEARPYRPFKSSEEYLEAMREDLAEWLSTLYPELSINADNFMDRLDTGVALCKHANYVRQAAVDYLARRQARNKSMTRSMTSGLAGPILAMGNVHYLPAAKSGTFFARDNVSNFITWCRKSLKIIECLLFETDDLIMRKNEKHVILCLLEVARRGAKFGMLAPMLVQMERQIDREIAADIKANGAGCSENGTQTDALETGNSSAATMTTITTTTVETDLYDDSDDSETEDDGDQNPVLMYGPQPQIITNDLKSLDEMVRDLVEKCTCPSQFPMVRVSEGKYRIGDTKVLIFVRILRSHVMVRVGGGWDTLSHYLDKHDPCRCRAQHRSSVAARLIPRQSPNHNPSNGIELHKAQVIFERSPPAARRVFNSPNCNGGPGTGSSCGTGVVGVAVPPTLQNGHSLSPNSGKYRSRSPTPQRKFLNQQANGGGIASATGSSQTVTTDTSSGQLLGSPSLARRSMSPSPRRLIDMRKKQSSLDSYSSGPKSLPGYSCSMEEANGGSGVGSAAGGVSSGSAGSGVAGEQGGANKFENISDNGSEISDEGYRSLGVIQSGAQKRESLHSQASIEDAESNARLDQTSSDSQISPSDEPAEKATTDILEEEDLNGQDREEDQEDYSVCDGPQSLPAILSGAHKLSDKFEQSGVFITDDEITVDIAKTEDQSVANTMGNPTPNLSKIPRSPLAQRRRRSIDNSTCGGAGGSLQDLSSRSGLPAPAFSRKQPVYRSVRTRNSTGATTTPVAPPRSRQATQLPMVRDVTNTWSGRTTGAPKRRPPCTADTFVAPTNGTGPAGSFERNGKGRSSQILYDSNGRRVRSGAPGCTSSLTTSPVKNHASSPLAQQLLEAASSAKNDAQILEKMKSLLSRYAAGNQTKAGVGATATAANKINSNGKKTPVYEDFTTAWVHSNGNLERSESCSPPAKARSKRSSAASSCESNNSNAGAGSGAAAGSASVVSPRRERGMSKIPAPVRHHTELY
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MHNIKDPTASAEGVEEVRALEDACLLLRRKGDMSNEAATQVLNLLAKIPLSYTFWNYRRDFLSSHQSADNELTLLVREHHITAKALEKNPKIYPVWEHRAFVFHRLLALADDPEMVEKLKKEEHYFIAAKLSEDPRNFHVWNYQRNLFDRVDLSFLYALLNKDCSNHSALHQLALELHKMRSEASDAGNTMFDHEVQRCLDFLRLSLLLDPNSESLWQFLIKMVDILPPEVLQELVEYVILSLEQDGCSFLPPHKQLDAPSANQIKDVYIRPPASYLLLASEDHIKGDIDKCKAYAEYCLFHDTFRKEMYNMLLQTIVHNSGQS
The following text describes a protein:
Function:
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity).
Subcellular Localization:
Nucleus outer membrane; Single-pass type IV membrane protein. Note=Localization at the nucleus outer membrane requires the presence of SUN1.
Domain:
The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains.
Sequence:
MALSLPLGPRLGSEPLNHPPGAPREADIVGCTVCPASGEESTSPEQAQTLGQDSLGPPEHFQGGPRGNEPAAHPPRWSTPSSYEDPAGGKHCEHPISGLEVLEAEQNSLHLCLLGLGRRLQDLEQGLGHWALAQSGMVQLQALQVDLRGAAERVEALLAFGEGLAQRSEPRAWAALEQILRALGAYRDSIFRRLWQLQAQLVSYSLVFEEANTLDQDLEVEGDSDWPGPGGVWGPWAPSSLPTSTELEWDPAGDIGGLGPLGQKTARTLGVPCELCGQRGPQGRGQGLEEADTSHSRQDMLESGLGHQKRLARHQRHSLLRKPQDKKRQASPHLQDVRLEGNPGAPDPASRQPLTFLLILFLLFLLLVGAMFLLPASGGPCCSHARIPRTPYLVLSYVNGLPPV
The following text describes a protein:
Function:
Component of the MIS complex, a complex that mediates N6-methyladenosine (m6A) methylation of meiotic mRNAs and is required for initiation of meiosis, progression through the meiotic divisions and sporulation. In the complex, mediates the entry of the MIS complex in nucleolus, where methylation takes place.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Note=Mediates localization of the MIS complex to the nucleolus during the period of m6A mRNA accumulation.
Sequence:
MMNKVDQIIGYKKYEVKLPKDRQVKKNKSKGGNVDQIDTKREKDKMRAFGEERKKFLDKMAKNKKKNTSRKDREKPKEVEKENYKREDKRLKEQKKLSLAKEFRFKEPNSEAINQNTAAENGKPKPQTGLDFDIDHQTVSKIMIDQAIQTSSPLNVQLTELFNDNVLDVSKDSQFVLQDMEFTSWERRWSNCSTTSNATTVSSVPDPKYNINYNDITSFNSVALITEDLNISASSNGLHERGKKLLQQEMEYSNKVKNVTIGLERLCMDEKPVPDAGITMQQASRWSEFPTCCDQAAI
The following text describes a protein:
Function:
Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Involved in multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex (By similarity). Plays a role in regulating nuclear envelope (NE) morphology and nuclear integrity, particularly during spindle pole body (SPB) extrusion or insertion through the NE, and perhaps during karyokinesis.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein.
Sequence:
MSNPDCLSKAISLVKTAIDNDNAEQYPDAYKYYQSALDYFMMALKYEKNEKSKEIIRSKVIEYLDRAEKLKVYLQEKNNQISSKSRVSNGNVEGSNSPTANEALDSDAKKLRSALTSAILVEKPNVRWDDIAGLENAKEALKETVLLPIKLPQLFSHGRKPWSGILLYGPPGTGKSYLAKAVATEAGSTFFSISSSDLVSKWMGESERLVRQLFEMAREQKPSIIFIDEIDSLCGSRSEGESESSRRIKTEFLVQMNGVGKDESGVLVLGATNIPWTLDSAIRRRFEKRIYIPLPNAHARARMFELNVGKIPSELTSQDFKELAKMTDGYSGSDISIVVRDAIMEPVRRIHTATHFKEVYDNKSNRTLVTPCSPGDPDAFESSWLEVNPEDIMEPKLTVRDFYSAVRKVKPTLNAGDIEKHTQFTKDFGAEG
The following text describes a protein:
Function:
Has a role in the initiation of DNA replication. Required at S-phase checkpoint.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MHDESRTKQISSIKALLKKWEHEYVHTNNCKPSKEDVKKQPEIALLYKQYYELKRESSITPKKAKTKVDFKFQTPTKQRAETEANESPKAPRNDYLQVTPKTVDKSLLGPTPQLSRRVLNLLEDMSPIADSHVDQISDIKHNTSEISSTMIPTTPSKNPEPVAQHTPTVLETPSSYRLQVYTSPNLLRVNAPCRKSLSEMLRELKDIEDDYGSNEEKILQEFESFSSSSSESLVDRDISQPMKKKIKRQNRLVKLPPSMNLSKSHLEGLPEIDEDAENGIDDNEDTTASKDSSPFLDLQSERQNKKIMRNGLVIGKQVSQNYSSYKLKKRKFRRHRS
The following text describes a protein:
Function:
Promotes cell fate progression in stomatal development. In leaves, needed to correctly orient spacing divisions, to limit the number of asymmetric divisions in neighbor cells, and to promote the asymmetric (amplifying) divisions of meristemoids. In stems, promotes the conversion of meristemoids into guard mother cells (GMC). Positively regulates CAPRICE (CPC) expression in differentiating stomaless-forming cell files. Forms constitutive complexes with ERECTA and ERL1 involved in the recognition of the stomatal regulatory peptides EPF1, EPF2 and EPFL9/STOMAGEN. Modulates the activity of the ligand-receptor pairs EPF2-ERECTA and EPF1-ERL1 in stomatal development. Functions in a combinatorial specific manner with the ERECTA-family (ERf) receptor kinases in the regulation of the immune response.
Miscellaneous:
MISCELLANEOUS: TMM lacks an intracellular kinase domain and may participate in active signal transduction only through physical interaction with other proteins. Overexpression of TMM leads to altered formation of trichomes.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MARYEFFRQIFIVLSIVSPLVRSFTVITSDSTAPSALIDGPQTGFTMTNDGARTEPDEQDAVYDIMRATGNDWAAAIPDVCRGRWHGIECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRPAPSGTVQHLSREEDGALPDGATDVSSTSKSLGFSYLSAFFLVFPNFIFMLISS
The following text describes a protein:
Function:
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Subcellular Localization:
Cytoplasm.
Domain:
IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
Sequence:
MIREPEFREYNPGQLEEKIEAFWKENNTYEKVKKLRENGPKYYFLDGPPYVSGAIHLGTAWNKIIKDMIIRFRSMQGYNVRRQPGFDMHGLPIEVKVEQALKLKNKREIETKIGVDNFIKKCKEFALNNLKIMTEQFKQLGVWMDWDNPYMTIKNEYIESGWFTLKRAWEKGLLEKDKRVLHWCPRCQTALAEHEVRGEYKMRKDPSIYVKFPIEWKEKEYLLIWTTTPWTLPANLAVAAHPEYEYAKVKVETENGEEYWIMAKALVERVLSEVGVKGEIVETFKGEELEGIRYTHVLLEEYPAQKEFREKYEWAHRVILGEHVTLEDGTGLVHTAPGHGEEDFEVGQRYGLPVYSPVDDAGRYTEGKWKGVYVKDADPEIIEYLKEKGYLVKAGEIEHKYPHCWRCKTPLIFRATDQWFLKVSKVKDQIIKENDEKVTWYPEWVKVRYDNGVMNSGDWVISRQRYWGIPLPIWESEDGEYYVVGSFEELVKLAVAIEVNGERIDLPEGYEEKLKIIEEKLGPEDLHRPYVDAFIIKVNGKEMKRVKDVVDVWFDSGIASWASLDYPRNKELFEKLWPADFIVEGEDQVTKWFYSQQAASVIAFDTVPYRAVAMHGYVLDEKGDKMSKSLGNIIRPEEVVQKEGRDPFRFYMLWATNPWENLRFSWKGLEQVKRMLNILWNVYVLSATYMSLDNFNPTKVNPEELPFREEDRWILSRVNSLIGEVTDGIETFRLTRATRGIYNFVVEDLSRWYIRLIRKRMWVEGDDPDKLAAYYTVWKVFDVLLRLMAPFTPYIAEEIYQNLIRPFVGVESVHMLDWPEADEKAIDEELEKEMEYARKIVEAGSSARQKARIKLRYPVRRIIIETEDETVKKAVERINRILRDQLNAKEVVVGKVERELIIKPNFAKVGPEFKGDAKKVIAWISEHGRELYEKGEMDVEIEGKTFHITREHVTIEEKLPDFFVAEEFDGGRVFVDKTLTRELLAEGLAREFVRRIQEMRKRLDLDVNDRIVVTIETTDENRELLQENLDYIMRETRAVEVRFEEAKGYVVEWPEVQAKIGIEKV
The following text describes a protein:
Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance.
Subcellular Localization:
Cell projection, growth cone. Cytoplasm. Membrane; Single-pass membrane protein. Synapse.
Sequence:
MNINDGGRRRFEDNEHTLRIYPGTISEGTIYCPIPARKNSTAAEVIESLINRLNLDKTKCYVLAEVKEFGGEEWILNPTDCPVQRMMLWPRMALENRLSGEDYRFLLREKNLDGSIHYGSLQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIVINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEEERLAFHLKQPEEYHYLNQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIFSLLSAILHLGNICYKKKTYRDDSIDICNPEILPIVSELLEVKEEMLCEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEQNIKTLSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEENSYIEFPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSKNAFISGMIGIDPVAVFRWAVLRAFFRAVVAFREAGKRHIQRKTGHDDTTPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSNNKKTWKKCKNNKLFKSTGKRLKILKDQKEAETRGDFILLSITRKNPRTPLSDLQGMNTLNEKNQHDTFDFSWNGRTGIRQSRLSSSTSLLDKDGIFSNSASSKLLERAHGILTRNKNFKSKPGLPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQAEPYFVKCIRSNAEKLPLRFNDALVLRQLRYTGMLETVRIRQSGYSCKYSFQDFVSHFHVLLPRNIIPSKFNIQDFFRKINLNPDNYQVGKSMVFLKEQERQHLQDLLHQEVLRRIIVLQRWFRALLCRQRFLHLRQASIIIQRFWRNYLNQKQVRDAAVQKDAVVMASAATLIQASWRAHLERQRYLELRTAAVIIQQRWRELYRRRHMAAICIQARWKGYRESKRYQEQRNKIILLQSICRGFRARQRFKALRERRLKETRLELGSSSIEPYGALEIQGSDPSEWEDRSFDNRVKAIEEGKSVIESNRISHESSMDYLKESPNKRQERARSQSGVDLQEDVIVRERPKSLEDLHQKKVGRAKRESRRMRELEQAIFSLELLKVRSLGGMSPSEERRWSTELMPEGFQSLQGTPDSGSSQGSLELLSCEESQKSKLEPIILDEGDFQIPSPKRSSSPKFESQDNALSASSETNYTLIQKGAPSDSVHLKNGTVKEKLGCGSEPITCKPQLRDSFISNSLPTFFYIPPQDPLKTISQLDTSIQRNKLLESEETLPALTLDISREARKYHFSEANQVVAYLNTDSSNTVLKKLEKLNTEKEERQKQLQQQNEKEMMEQIRQQTDILEKERKAFKTIEKPRIGECSLAPSFHQSKRRIERPSSLLILNTPNKEEPSVLGPLSVSVKDAALAPKDSPSAHLPLKDPHVTLFFERKGGPCQSSTVKELSKTDRMSTQQNIACKLSNNRISKREHLRPTQYYSHKSDDPSGDGATRAIFFTPKDNMSISLVDKEALNSGNPQLHKQDEPAWKPVKLTGPGQREVARPAHKKKARMARTRSDFLTRGTFADGEGDTEEDDYDDIIEPLLSLDQASHSELGPTPSLGQASHSDSEMTSQRFSSVDEEAKLHKTMSQGEITKLAVRQKASDLDIRPQRAKMRFWAKGKQGEKKTTRVKPATQSEVLALFAGSEMIPAHQFPEELAQYHPTPPLSPELPGSCRKEFKENKEPSPKAKRKRSVKISSVALESMQWQNDSVQIIASASDLKSMDEFLLKKMNDLDNEDSKKDTLVDVVFKKALKEFRQNIFSFYSSALAIDDGKSIRYKDLYALFEQILEKTMRLEQRDWNESPVRVWVNTFKVFLDEYMNEFKTLDCIPTKVPKTERKKRRKKETDLVEEHNGHIFKATQYSIPTYCEYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVELSRLTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEDSNRMSANALAIVFAPCILRCPDTIDPLQSVQDISKTTTCVELIVVEQMNKYKARLKDISSLEFAENKAKTRLSLIRRSMGKGRLHRGNYPSPSSPVVVRLPSMSDVPEETLTSEAVLETDITEQQQAAMQQEERVLTEQIENLQKEKEELTFEMLVLEPRASDDETLESEASIGTADSSENLNIESEGAISEKSERSLALSSLKAAGKSEPSGKLRKQLKKQQDSLDSVDSSVSSLCSSNTASSHGTRKRFQIYSKSPFYRAASAGEAPGMEGLLGQTKSLEDRPQFISRGTFNPEKGKQKLKNVKNSPQKTKETSEGTVVSGHRRTVDPDCSSTQQLALFGNNEFMV
The following text describes a protein:
Function:
Catalyzes the reduction of free flavins (FMN or FAD) by NADH. Subsequently, the reduced flavins diffuse to the HsaA oxygenase subunit.
Miscellaneous:
MISCELLANEOUS: Cholesterol metabolism contributes to the survival of M.tuberculosis in the host by helping the bacterial multiplication during earlier stages of infection and to the dissemination of the pathogen in the host.
Sequence:
MSAQIDPRTFRSVLGQFCTGITVITTVHDDVPVGFACQSFAALSLEPPLVLFCPTKVSRSWQAIEASGRFCVNVLTEKQKDVSARFGSKEPDKFAGIDWRPSELGSPIIEGSLAYIDCTVASVHDGGDHFVVFGAVESLSEVPAVKPRPLLFYRGDYTGIEPEKTTPAHWRDDLEAFLITTTQDTWL
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins. The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation. Involved in the control of endoreduplication.
Subcellular Localization:
Nucleus.
Sequence:
MREEEIEKIRGVVRDCVSKHLYSSAIFFADKVAALTNDPSDIYMQAQALFLGRHYRRAFHLLNASKIVLRDLRFRYLAAKCLEELKEWDQCLLMLGDAKVDDDGIVYDAKDGNVIDFDKDGEDREINISSAICFLRGKAYGALQNRSQARQWYKAAIKADPLCYEALECLIESHMLTSEEESSLLSSLQFSPEDGWLSSFYSCLIKKYDKESTVELKFKKLENETSGSVSGSSMITLANNTDLLACKAEYYHQCCEYQKCFELTAALLEKDPFHLKCTLVHLAAAMELGNSNELYLMACNLVKDYPSKALSWFAVGCYYYCIKKYAEARRYFSKATGIDGSFSPARIGYGNSFAAQEEGDQAMSAYRTAARLFPGCHLPTLYIGMEYMRTHSYKLADQFFMQAKAICPSDPLVYNELGVVAYHMKEYGKAVRWFEKTLAHIPSALTESWEPTVVNLAHAYRKLRKDREAISYYERALTLSTKSLSTYSGLAYTYHLQGNFSAAISYYHKALWLKPDDQFCTEMLNVALMDECQNGVDSKVELC
The following text describes a protein:
Function:
Catalyzes the phosphorylation of pantothenate the first step in CoA biosynthesis. May play a role in the physiological regulation of the intracellular CoA concentration (By similarity).
Sequence:
MGGLRVDLSGAEIRVDPACGAAADDGGSPPVFLPRQPAAPPLLALDIGGTLIKLVYTASCGGGGAELRFAKFERRRMQECFDFVRAQGLVHRNGSTMGSSKENIALKASGGGAYKYTEDFREKLGVCLDKVDEMDSVVSGANFLLQSVPGAAFTHMNGKKSSVDISPNNLFPYLLVNIGSGVSILKVTGNRKFERVTGTHIGGGTMFGLAKLLTGCKSYDEFLQLSQKGDNFVLDLIVKDICGELVCQKQGLSTSTLASSFGKVITSKKKLTDYRPEDLASTLLSAFTYNIAQISFLVASILHLRRVFFGGSYIRGHKSTMQNISYAIDFWSQSKMQAVFLQHEGYLGALGALMSYGDSGDKNMNLEEMKEEENIHESATPIDETSTDEHNDGNIFPYLLVNIGSGVSMIEVTGNGKFERIIGSHLGGGTILGLARLLTGCSSYDEFLELSQRGNNLAVDLTVGDIYGEHGYPKIGLPASTTAASFGKVSSSRLSEYKVEDLAAALLNSFTYNIGQIAYFVANLSGLKRIFFRGAYICGHEKTMDKISHSLKYWSKGQVQTTFLCHEGFLGTLGAFWSYENMGIDGLAAHEVIREVLLGAPYTGQLPSLPLTHQQDNGEDTTIEGEVERLRHDNAVLKAELERLQRENTELKAKLVKSGKPNTFYH
The following text describes a protein:
Function:
Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
Sequence:
MWESIKGFFRRHKRKFVVGGIVITGIYIVSRYARWRLDEWRANQELEYIAQARKQHHFESNQRTCSVTLYSLIPSLRDSLLDKLNTEEITAKLREKPANKLELWESLKTLSFARTVTAVYSSCMLFVFLRVQLNVIGGYMYLDSLVTPVEGGSNGKRKHVAEGMQKKYLALVKYLLSEGLDKMTDTIKRSTEDILSDISLKDKLTHAELQRLINHIRQTFEFSQQTSSSMRSSQTGSTPLSSTRPFCQFMVPEDMAALDGRGETAVGGVEGEEFMRLVEETLDVLESEDCSAVLQGCLDVAFAHILGNIAPFFQAEELGMSFKYLLAVSLPLAKIIPIVNGQIYHMFSDSDNSYLQDLFKVRFAGEFAANVYEAFSTEVD
The following text describes a protein:
Function:
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Subcellular Localization:
Cytoplasm.
Sequence:
MEFTIDRDTFSRALQKIQGIVEKRNTMPILSNVLIEALEDRIELTATDLEVGMKSSYPTTVASQGKITVSAKKLYEIVKELPDETISFLTKANDYVEIRCGKAKFTIVGLSSEEFPYFPKVNEESFIRIESGLLADMIEKTSYAICFDETKYNLNGTFVKASEEDGRSILRMVATDGHRLSITQREFNGAVSPEMAKGVIFPKKGIFELKKMCEEESTQLSLGFLDNSAVIVKGNTVVVMRLVDGEFPDYTRVVPVANDRIVTVARDPFFHSLRRMSILSSEKFKGIKMDIQESGMVISSSNPELGEASEELDAVFAGDAISIRFNAKYLIDVLAVLDESSVALHLKDELSPAIVRPADGDGFTAVIMPMRL
The following text describes a protein:
Function:
Phototransformation of protochlorophyllide (Pchlide) to chlorophyllide (Chlide). PORA may also function as a photoprotectant during the transitory stage from dark to light. Functions in skotomorphogenesis, photomorphogenesis and throughout the plant life under specific light conditions.
Miscellaneous:
MISCELLANEOUS: The presence of TOC33 is not required for the import of PORA into plastids.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MALQAASLVSSAFSVRKDGKLNASASSSFKESSLFGVSLSEQSKADFVSSSLRCKREQSLRNNKAIIRAQAIATSTPSVTKSSLDRKKTLRKGNVVVTGASSGLGLATAKALAETGKWHVIMACRDFLKAERAAQSAGMPKDSYTVMHLDLASLDSVRQFVDNFRRAEMPLDVLVCNAAVYQPTANQPTFTAEGFELSVGINHLGHFLLSRLLIDDLKNSDYPSKRLIIVGSITGNTNTLAGNVPPKANLGDLRGLAGGLNGLNSSAMIDGGDFVGAKAYKDSKVCNMLTMQEFHRRFHEDTGITFASLYPGCIATTGLFREHIPLFRTLFPPFQKYITKGYVSESEAGKRLAQVVADPSLTKSGVYWSWNKTSASFENQLSQEASDVEKARRVWEVSEKLVGLA
The following text describes a protein:
Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MSSRRTRPRVVTGVLAVLLAASWSPLPRGTAVHVAATSYRAVDPVVNVARGKPVTANVTCGSPAEDFYPHSDSVKPPPDRQLQICDASDPVLAHNASLMTDGNSSTWWQSTSLRQLMSAGNGLGNQAEVYITLDLGATYHPENITIHMGDTKRPGRLAIMRSNDGMNFDPWLYLVTNGNRDCRRFGVAMQPEPDGSPESVVCREYAQLGVEQLYNERITVSLSEVPPSFSDEALLMWQAVRHLQLSFYDMDLVLGIFEDQFHHYAVSEVSVMAGCECNGLGIGCEISADSGQYECICSGNTQGPFCEECQPLYNQFPYQPGQPCQACNCNNHSQVCVYNETVAAGNLSMSANGSFHGGGVCLSCRDNTTGTNCEQCDTLFYRNPEVSHQSSSACLPCECDLVGSSSSQCNMETGQCPCKPGVGGRMCDVCLPGYYNFSSGGCTPCPCYPLLHHTPCYVDQGGQVTCNCTQGHKGEQCERCEDFYWGDPVHGTACAECDCSGNSDQCSNVTGECIGCHGNTTGFNCDRCADGFFGDAVFGNCSACACDEAGSVALVCNHTTGLCPCKPGVDSSTRRCSRCMENHYGFDTPDGDGTDSQPGCSPCNCDVLGSTSLQCGEGGNCSCHPGVEGTKCDVCMEGTYGLPDMECLACDCDPVGTLSDFDPFLPTTTQSAVGQTTILGLTTTQDITTQGALIGSTPIQGITDDTTLQAETTAIVTTEATTNVTSSATSQGPETPSVTTVQAETTDTTTTVDTTNVTSSATSQGPETPSVTTGQTETTDTTTNITSSATSQGPETPSVTTGQTETTDTTTNITSSATSQGPETPSVTTVLAETTVIPTTVATANDTSSATSQGPETPGVTTVQETTDAATTVATTNNTSSATTQGLETTDVTTVQETTDTVATTNGTTSATDTSLGTTDFAGTTNITSVVAITNDMTVPTETTNITTTVTTDGLETVGVTTVQTETTDIATVVTTTNDTLDVSVATEVVTTDNDTAVTENATTVTPLATANVPAVSTNATE
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of cd86 and MHC class II proteins, such as hla-dr alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies.
Subcellular Localization:
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
Domain:
The RING-CH-type zinc finger domain is required for E3 ligase activity.
Sequence:
MHSCWKMKLQNEKTLGHSVSRSSNISKAGSPTSVSAPSSFPRTSVTPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKFEFIMETKLKPLRKWEKLQMTASERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKMGQNNGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETCKKKIFEKSVIIEPNLESKEALGIHHSDTNSSYYTEPEDCGAAILQV
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAMYTTMAILTLTSLIPPITATLINPNKKNLYPHYVKMTIASTFMISLFPTMMFMCTDQETIISNWHWTATQTLELSLSFKLDYFSMMFIPIALFVTWSIMEFSLWYMHSDPNINQFFKYLLIFLTTMLILVTANNLFQLFIGWEGVGIMSFLLIGWWHAREEANTAAIQAILYNRIGDIGFILALAWFLLHTNSWEPQQMILLNSNPNFLPLAGLLLAARGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGVFLLIRFHPLTENNQLIQTLTLCLGAITTLFTAICALTQNDIKKIVAFSTSSQLGLMVVTIGINQPYLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLFKTLPLTSTSLTIGSLALTGMPFLTGFYSKDLIIETANMSYTNAWALSTTLIATSLTSAYSTRMILLTLTNRPRFPTLTNINENNPTLLNPIKRLTIGSLLAGFLIINSIPPTSPSQTTIPLYLKLTALSITLLGFLTAFDLHLLTNKLKMKNPSHTFHFSNMLGFYPNTIHRTIPYASLTMSQNLASLLLDLAWLEKLMPKTISHHQISASVTISSQKGMIKLYSLSLLIPLSLTLLLIM
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MVAERTPYSSFASLLAAYQEQYSQAGPSTQLDSPISHEAVLDEQSGLIISLMESLEETIRSKTPTNCSSFEMDGEEQISEDEYKALLSEHRAWQLIRAVYDNRIPRTDPNFVPPSAAQQIIENPYTSPEDLVQTMVIEDPELSLWATLVEHLQTRPLLTSPPPLEARHGYLPSTVRRSKFHSTTDSPSLDPDFTVRDPHSSSLAGEDQTYQLPLLETLYNLVRYGELESAIKVCEQGGEPWRGASLMGVRRWTMGGMSKGTEPTVMTGNRYRALWKKSCRTIAKNHTLLPAERNLYAAMISDLPTLLPACESWEDYLWAHVQHRIEARLEKRWRELGGFWEGEGGVGKDDVEEVEMAKGGLEEVFASMRNLQNASISITMTEPYHVAQQMILLDRTEALFHGFADQLLELESGVSPELIAPLLRFFTHLALILRTLSQPVPVSAANAIIQAYLQILEREGNDKLVAMYAACLREGSGEESYARFLWSMDPSAGRDSRSEALLRAKKHNLDVALIARETVRLCLEEVVADPPKRLLAEPDIVPISIGLTEHDVVLIRSIEWLIILPETADDALVRSCQLVRYFLSKGQANAAQSLLLSLPSLPTSSSLTNQSHLLELASYNRLFSLFSSHTYFADILFRQPSLTASKLEVHAWKKDLEACVEDVWKGTVGLIKERWLDLPSLSPKVEKDGKGLYEYEGEEERQKQLKLIRHIFIPDLVLRLHNTLIEQSVLFPYFLQRALELASIVADGRYRVYEGFLPLATIAGGAEMVGGGEKGVSRLEVYMDKIREVALEVLKSGNGNAFKVRRLA