lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Calcium-dependent cell-adhesion protein. May play a role in activity-induced synaptic reorganization underlying long term memory. Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Postsynaptic cell membrane. Presynaptic cell membrane.
Sequence:
MGETGWCGLLVLACLVSLADVAQGKTVKYQTFEEDAPGTVIGNLAKDISLSPSSSRNNFRIMKQFNSSFIRLRESDGQLSIGERIDRERICKHTLQCLIAFDVVSFSKEQFKLIHIEVEVKDINDNSPEFPRKESSLEISENTAVGTRIPLDFAVDEDVGVNYIQSYQISVNSHFSIDVLSRADGVKYAELVLMKELDRETQASYALELVAMDGGNPSRSGTTRINIKVKDYNDNSPVFDRKSFSVDLREDAPVGSLLLDLNAEDPDEGLNGEVVYGFGHQVPPEIRQLFRVDRKTGRLTLESPVDFESKTTYEFDVQATDLGPNPSPAICKIVVQVQDVNDNAPEISITPMTSITAGIAYITEAAARESFVALVSTSDRDSGANGQVHCTLYGHDHFRLQQAYEDSFMIVSTSPLDREKIPEYNLTVVAEDLGSPPFRTITQYTIRLTDENDNAPVFSKPVYEVAVVENNPPGAYITTVVARDMDMGSNGKVTYKLADTYVMGSPISAFVSLDPASGSLYALRSFNYELMKHLELRVTASDGGSPPLSGSASVHVRIVDQNDNSPVITQPPLNNGSAEVLLPRDSPTGYVITRVEARDADEGVNSELSYGLATGEPSVFSVNKVTGEIYLNQVLSHDVDETLSVTVTVSDNGRPALTSTATLHFLIIEGSPPSDRTLYQPGDGDDAHAQWDLSVVIIVVLAGSCTLLLLAIILIATTCNQRKRDKSGEDSDSYGEKGTLERARTHVVDNPLLPLHGAAGGEAFEGHSYASQPGGFTPAHPVSNDTCSASEDGSEVPCVYDSDNKLRGNKHEGYSTLPGYGNGKEAVRPITIWKGNSYTTISARDPAFSGKDSGKGDSDFNDSDSDVSGDTGLKKDGVVVPPMGGQNALWACTSECKVLGHSDRCWSPSAVRASVAPSPAPTLSSFSSLPKTASLPRDPNRRDNYYQAQIPKTVGLQSVYEKVLHREYDYVLVTPPRPVRVQEISDMSIPVYTPTPTHCPNNANEA
The following text describes a protein:
Function:
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
Sequence:
MVISCMMAYSNCRPFVIRFWNRRDSHSHSTIWKKARGFRFGDGSLRITWDDVFRIESDGVDSYANREYIDRVRDCNRGADLQSGFLPFLVEDALVGYIHNRFVNHIKGFEDVFVCPGNFVTLHPSLATPEDRTRAVGNVIKSLGELIPGTRNELFPAIPSFGMPAYFSLERAAVPYFGVKAYGVHVNGYVERDGKKLLWIGKRSEKKTTFPGMLDHLVAGGMPHGISCKDNVIKECEEEAGIPPSIAERAAPVGAISYMDIDGEKYKRDVLFCYDLKLSEDFVPKNQDSEVGSFKLIPVTQVAKIIQTTEFFKPNCAIVIIDFLFRHGYMNPDVPGYLELFQILRSGDCS
The following text describes a protein:
Function:
Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-1 to regulate the formation of the granular structure of P-granules in embryos. May protect somatic cells from excessive apoptosis during normal development.
Sequence:
MSFSDDGWGAEAEVKVAEDVPEKNVPPPVEPPRAPQSTAIKTEPERNSDEPSAGFGIDPITTSKTFGSQTTPKTEFGGAPSLSGFGGNAAAAAANKTSFDQQGNGFGGAAKHGFGGVGGAPSSFGANVIPVNKPSLGHKTTGFGGEPKHVSGGAFSSANNFDQQDKGFGGAASSGFGNGSMLTNQKVGLENQTTGVGASEVPTSKPSSFGQQPAVVSGFGGAAKMGFGGSSSSGFGGQKAGATESSGFPTKETSTSQPGFGGDSSTGFGSGLKAGFGGHGAGAAENSGLPTETTGFGGKLPSAGFGASSSNESAFGQQSKGFGGATKNGFGGDSSSSFGSGSKAGFGGTSSSGIGGQKPGATESSGFPTKETSTSGGTFGSGFGGKPTSTGFGAPSTTDSSSGQQTAGFGGASKPGFGGDSSTGFGSGLKAGFGGHRASTAENSGLPTETTGFGGKLPPAGFGASSSNESAFGQQSKGFGGATKNGFGGDSSNSFGKRDSGFGGPQDQGFGDTDAPSKSGLGSFNTGGGAVKSAFGAAGFGSSSNFGNGNTFGEPSDNQRGNWDGGERPRGCHNCGEEGHISKECDKPKVPRFPCRNCEQLGHFASDCDQPRVPRGPCRNCGIEGHFAVDCDQPKVPRGPCRNCGQEGHFAKDCQNERVRMEPTEPCRRCAEEGHWGYECPTRPKDLQGNFLESYDFVFTPDDKMFEDAVNNDDKIDFDQKVVASTGKVEIPDMASFDGFKILPQDLHDNLKRMKMNRPTPIQRASFFPIMHGNDVVACAHTGSGKTLAFLIPFVIKLMEEFEKDRDVTDEKPSPRLLIVAPTRELVNQTFTTARQLTYETGLKCGLAFGGYSRNANVQHLRSFSQLNILVATMGRLQDFVNAGEVSLSKMKYIVLDEADRMVDSNDFGEEVSKIIGSPGERTQQTVLFSASFSEDLQSDDLPKFVKEGYTMLQVDKFGTANEKIDQKILPVPRTEKRDAIYKLLGIDENTVTLLPDAPIEKQKTLIFVNSVKFCDTLAALISSAGVSTISMHSYQNQEQRDRTLDDFRRGKYQCMVASNVCARGLNIAGLDHVVNYDMPDKNGFDEYVNRIGRTGRAGFTGTSTAFVDVENDTDIIPCLVSILNEAKKEVPEWLTEGAGHQEEGGDDWNEQEQEW
The following text describes a protein:
Function:
Metalloprotease.
Sequence:
MRRLLLLLLIILSLAAAQWNEGRNEDKRRNDFSATASTAESRNGQTFFPGSSTHFGRGDDPSSGRGGFEERNRDKNGGSSILTSGRNSRGELNGNEERPGNNRDSKRENENGRRGNMDEKLIDSTYSNRQSSKRGQGKGWKRSRPVDKAHAFFNLRKFGKGTREMRSEDWKEHADQFCNLFPHHKKCRDGARPLQSDIASVSKAIERRHQRRRVPKLKEIDWLGGVPETLRQRAKDRKEKFGNTSVETRNFFKNSCRSGRVNCRIQPDQARKDRRMLRDHMAKVEKEKLNLDEETADDNVEIRFDRTLRIKRALLEKANLTAEIDPIDNGIFEQDILLTENQSNMILNHLDKANTTGDENLSPDEIDEVPKDLTVLPPSDPVVAAAAATAAVDTAPVDTPTESTPSSETPPPPTDGTVDGVPGDTATRMKRSGVFVEQNFAEKWDISTPIPYTFDESIAPWDKTDITDALNEISRVSCVRFRFLSTPPNSYHINFVKIDSPTFCGLSYVGRVSPVNTVYLSFQCGKNKGVVMHETFHALGVIHQHLRVDRDNFIKVDWANVNPQKYDQFATADQSLYTSYGIKYSYDSIMHYNAYTNAIDVRKPTMIPLVNSASNLALLGQRDQLSPTDISLINKMYCKPASCVDTNIYCGHWALTGTCTLQGNSIWMSQNCRKSCNLC
The following text describes a protein:
Function:
Required for CNS development; negatively regulates glial cell division in the embryonic midline. Involved in the metabolism of insect hormones; responsible for ecdysteroid C22-hydroxylase activity. May be involved in the breakdown of synthetic insecticides.
Miscellaneous:
MISCELLANEOUS: Member of the Halloween gene group.
Subcellular Localization:
Mitochondrion membrane.
Sequence:
MLTKLLKISCTSRQCTFAKPYQAIPGPRGPFGMGNLYNYLPGIGSYSWLRLHQAGQDKYEKYGAIVRETIVPGQDIVWLYDPKDIALLLNERDCPQRRSHLALAQYRKSRPDVYKTTGLLPTNGPEWWRIRAQVQKELSAPKSVRNFVRQVDGVTKEFIRFLQESRNGGAIDMLPKLTRLNLELTCLLTFGARLQSFTAQEQDPRSRSTRLMDAAETTNSCILPTDQGLQLWRFLETPSFRKLSQAQSYMESVALELVEENVRNGSVGSSLISAYVKNPELDRSDVVGTAADLLLAGIDTTSYASAFLLYHIARNPEVQQKLHEEARRVLPSAKDELSMDALRTDITYTRAVLKESLRLNPIAVGVGRILNQDAIFSGYFVPKGTTVVTQNMVACRLEQHFQDPLRFQPDRWLQHRSALNPYLVLPFGHGMRACIARRLAEQNMHILLLRLLREYELIWSGSDDEMGVKTLLINKPDAPVLIDLRLRRE
The following text describes a protein:
Function:
Nucleotide-binding protein.
Sequence:
MSDPSFDVVSEISRPELTNAVTQALGEIKNRFDFKGSKSDIQLEDEQLVLTSDNEAKLESVIDVLVSKMAKRGLGLKNFDFKSKIEPATGGTVRMKVKIRKGMEKEQTKEVTRIVKESKLKVNATIMGECVRITGKKKDDLQEVIHLLKNSDLPFDVQFTNYK
The following text describes a protein:
Function:
Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZNF445, but ZFP57 plays the predominant role in imprinting maintenance. In contrast, in humans, ZNF445 seems to be the major factor early embryonic imprinting maintenance. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element.
Subcellular Localization:
Nucleus. Note=Binds various differentially methylated regions (DMR), including the Snrpn DMR.
Domain:
The KRAB domain is required for function as transcriptional repressor; Zinc fingers 2 and 3 mediate recognition of the target element, ZF2 interacting with the 5' half (TGC) and ZF3 interacting with the 3' half (CGC).
Sequence:
MAARKQSSQPSRTPVSYEDVAVSFTQEEWEYLTSTQKTLYQKVMSETFKNLTFVGSKKKPQEPSSDLQDKNEEQEKSSSCTGVFKGGPFFFCLTCGKCFKKNTFLFNHQFPVRSRRLAVTNPQSRKGKGYKAQHRGERPFFCNFCGKTYRDASGLSRHRRAHLGYRPRSCPECGKCFRDQSEVNRHLKVHQNKPAASNQAGNQASNQRLKSRVPPTTPRSQAPALKYVKVIQGPVARAKARNSGASTLNVRSNSITVVRSREKISCPYCHITFTMRTCLLTHLKIHFRRQPNQHFCCKESAHSSNTLRMQKIYTCPVCDSSFRGKESLLDHLCCQRPIRFSKCWEILGHLLGYLHEPVVLGNIFKVRDSSGKRMESRRRRRKRACTENPETEGLSGKGRVAPWEMEGATSPESPVTEEDSD
The following text describes a protein:
Function:
Functions as a component of a mechanosensing system that transmits signals triggered by external osmotic changes to intracellular factors. Probably plays a crucial role in cellular protection against high osmotic pressure. Also confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks. Lacks measurable transport activity.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MQDLISQVEDLAGIEIDHTTSMVMIFGIIFLTAVVVHIILHWVVLRTFEKRAIASSRLWLQIITQNKLFHRLAFTLQGIIVNIQAVFWLQKGTEAADILTTCAQLWIMMYALLSVFSLLDVILNLAQKFPAASQLPLKGIFQGIKLIGAILVGILMISLLIGQSPAILISGLGAMAAVLMLVFKDPILGLVAGIQLSANDMLKLGDWLEMPKYGADGAVIDIGLTTVKVRNWDNTITTIPTWSLVSDSFKNWSGMSASGGRRIKRSISIDVTSIRFLDEDEMQRLNKAHLLKPYLTSRHQEINEWNRQQGSTESVLNLRRMTNIGTFRAYLNEYLRNHPRIRKDMTLMVRQLAPGDNGLPLEIYAFTNTVVWLEYESIQADIFDHIFAIVEEFGLRLHQSPTGNDIRSLAGAFKQ
The following text describes a protein:
Function:
Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEESFPRGGSQKKAEQKAVLKRPKENDGNLFSTHHEEEPEIKKNKKVSREKPKAVGLEKRTTSTKEIVEIPLYSKLSVGMLFLGCVKRTKDFELTVSLPYCLTGYIQATNICDAYTNLISEQVEKDDPLEALVPLSELYSPGMLVRCAISSLETTASGFPSVKLSVNPKHVNKALNTGSIKTGMVLSGCVSSVEDHGYLVDIGVAGTKAFLPRQKAQLFLSQAGQGSLLRVGEYLNCVVEEVKNEGKIVRLSIIQNDVASALATVEQNWNLNNLLPGLVFKAQIEKVMHNNITLSFLSSYTGFVDFLHFEPKKIGSYKEGQEVKACILWLDPSTKTIRLTLRQCFLQPGNTLPQLTSDWVGSVLDNCVVQTLFKNAGAVFELEGGNLGFAFKHHLSASKQPHFEKFKKGTTHKGRITDFSPMDEMHILSLKEKVITNLFLRHEDIQPGQVLEGTVKCMEAVGMVVQITDHLTGLVPKLHFADVLLKHPEKKYIIGNKIKCKVLTVVTCERKLILTRKRTLMKSTLPVLASYEDAQPGLITHGFIVAIKDYGCLVKFYNEVQGLAPRRELGSLQEISSLEDAFYRGQVIKVQVLECNPQTQQLLLSFRITEEGHTEQEQRFLKKIKAVKLDVGKLVDIRVLSKTDKGVNVLVLPEESPAFIPKMHLSDHVSNCELLWHTLQEGDDIPGAMCLSSLKGHSILTKKSLLISSVEKGSCVKVISEVQTGMHLTGFVKSIMPYGVFVEFPYGLFGLVPMSEISDKFVTNIRDHFVEGNTVVATVIKMDEEKKRFLLTLKMSECAPDDYSIEGLFLLSQCFSELQLMKGLLARKGDPEDELSIYTLIAGQKLTLVVENAEENGPVQFSAGSISGAQTVSATQYHIGDKALVAGQKVKAVVLHVDMLTLHVHVSLNQTLLKKKQNVPKMNSSHSADVQHVAEEFAVVSLADSAHLIAVPVSSHLNDTFRFESEKLKVGETISVILKTTTVNEHGLLLAVQNKAASKTSKNLGRTTQSAMRVRGAISHGLKIGDLVTGTVKSIKPTQVTVSINDNVFGFIHVSQIMDETPQGCFPTSKLNPKQEVTCRVIGGREVKTHRYLPITHPDFIHSVPELSLLPELINTDNVPKPRALKTFNPGDKVTCYVNKFNTETKYLEVEITPEIRGRIELLLLSQTPKNLKRPEKLFKNGQALSATVVGPDAVHKHLCLSLTGIHSLEEGAVTVACVTKVVKGSGLTLSLPFGKTGNANMFHLCDKYAEASLEKFTPGKFVRCAILSNSKIVKVSLRQSRVNQQAQSSAVDEDIASIDSLEEGQLVSGFVSAITENKGVFFRLSSFIVGHIQFQNVTSYFVYEPSAYSNYIPEGTLLTAKVLSIDPDKKHVELSLLPTDTGKPDVVPESAGFSKRKNKASKKTPTKRKRENLEKGSQDTGLKKKKSHKSIEDDDSGVEVYCREEDAEDKTKKTQQQSQEQTSSQASVSRLQVSSGFLWDVSLNTLKTSLAGANESSSDSDEEEDEQPKKKKTKKELAKEKKEAEKELSKKEATLLDSSRQPQSADDFDRLVISSPDSSILWLQYMAFHLHATEIEKARVVAERALKTISFREEQEKLNVWVALLNLENMYGTEESLTKAFERAVQYNEPLKVFQQLADIYIKSEKFKQAEDLYNTMLKRFRQEKSVWIKFATFLLKQGQGDGTHKLLQRALKSLPEKDHVDVISKFAQLEFQLGDTERAKALFESTLSSYPKRTDLWSVYIDMMVKHGSQKEVRDIFERVIHLSLAAKKIKFFFKRYLEYEKKHGSTESVQAVKEKALQYVESQSSLAAT
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MASSTNSNPTNKTQNSKLASDLNKSSTPNPQQDTLGEDDEFEDFPVENWTAAESDISSLANTVDQAKQANGGRGSTTDGQANGKKVTMDDLWEDNWDDDVIESDFAHQLRAELEKTKSNGTGPTPMQT
The following text describes a protein:
Function:
Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MQQKPRNNGYPGTLICAVLLVLLSTGVSGQKQYSKARKLELREDVRRMFQHAYDGYLRHASNYDELRPLTCDGHDTWGSYSLTLIDALDTLATMGNFTEFRRAARLLEEKMDFDRDINVSVFETNIRIVGGLLSAHLLSKRAGVELEPGWPCKGPLLRLAEDVARRLLPAFVTNTGMPYGTVNLRYGVPKGETSITCTAGVGTFLIEFGTLSRLTGKTIYEDVAMKAVHALWAYRSPIGLFGNHIDVQSGRWTALDSGIGAGVDSLFEYLVKASVLLNRPELLELFHEARAAIDKYMRKEDWYVWVGMNKGRVTLPVFQSLEAFWPGILSIIGDTEPALRTISRYIGVWKKYGFLPEFYNIAAGEASPNREVYPLRPELIESAMYLYRATGNEYLLEFGEHMLETLEFSAKTKCGYATIRNVVTHEKENRMESFFLAETSKYLYLLFDEENFLHNDGSGGELLSTEDDVCVVQAGAYIFNTEAHPMDMSALHCCHAHNEDIYTSLDLQRFSPRAILERSKKRQVAVQEQWVPQCHPENNEFFNKEDESVQAQDSEKEQEREQSGTSTTMAVDIEVFDEFQQPAGDLLVSNFEQIREERELNESLHRNVVARNQLTVSDLDEFFAQRRESFASASEALNYVKTFMGNYTMDVAFIRGLQLYDTNMSSVLGTGAQKEYESRMRTLWQLYELQQQYVANIRVIQGLGLLTFPADGDRIPSHLTEVLDSLDKSAHLEHMDLQDLETRVSNTSSPQLAHIREVILKARNAYAIAMVNTSAMQEFAIRIYLSGTSEAGVRIHPLLEDGELSEEARKRPLKLAEERALFSYARRIVDFRKRMAETVDRLQTLMQDIPPPKRKEATTDSQAADASTVYTQTKAQMAAPAQQPEPSQEEKQSTQIQKGKLAENGSGLGEEESGCVWSQLVQTILRKTTVQRVKFDEAVLQENTRKALEKYARKELPHHLFACHRPEYIEGFAYRDFYPEALKVRRRCAHDNERLNCRAKRTER
The following text describes a protein:
Function:
Involved in the production of sphingoid long-chain base (LCB). Is required for the cold-induced accumulation of phytosphingosine-phosphate, the regulation of the cold-responsive MPK6 and reduction of root growth at moderate low temperature.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRSTCCTPLCPFTAKQPSFLRKQQRITSDRFTFRGGGGGDAAAVVSSSGLRDLVFVVNPQGANGRTAKEWKKLLPHLRSRLGKDCNVSELLTSGPSHAIDITREAIRDGADAVIAVGGDGTLHEVVNGFFWEGKPVGYLSGEASRSTALGLIPLGTGSDFARTFGWNNDPCEAVERIARGMRSRIDVGVIDKEGKDLHYFINVADVHLSAKAGFYASKYKKFGNLCYVIGALQAFMGHHNQDMRIRVNGGEWEIYPQVTALCVGNAKYFGGGMKITPNAIPGNGNLEVVVLQNFKWYDFVLKLHKLYNGTHLSVNNVTSRSVQSIEVEEITDSGSIYVQSDGEHLGFLPRKFQVLPGAIDIIS
The following text describes a protein:
Function:
Involved in 1,2-propanediol (1,2-PD) utilization within the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. CoA is regenerated within the pdu BMC (for use by PduP) via this enzyme, although there must also be cofactor transport across the BMC. Directly targeted to the BMC (By similarity). Phosphate is probably the first substrate to bind in the forward direction. CoA is probably the first substrate to bind in the reverse direction, and might bind to the enzyme as the BMC assembles, ensuring cofactor encapsulation (Probable).
Subcellular Localization:
Bacterial microcompartment. Note=Probably located inside the BMC shell.
Domain:
Formed by 2 beta-barrels, each is capped on both ends by short alpha-helices.
Sequence:
MDMQQETIERIIRQVLGQVGPAGGSIATLSGDAGVDPFQVAVGVSNRHIHLSRTDMDTLFGPGAELQRKKAMKQPGQFAAEETVTLKGPKGSLSKVRVLGPLRRETQVEVSVADGFALGITPPLRQSGQLDDTPGLTIIGPQGSVTKDHGVIVAQRHIHMHPSTAAKLGLRNGDEVDVEAGGERGGVMHRVLIRVAEASADEMHIDVEEANALCLKNDDVVRICKK
The following text describes a protein:
Function:
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Sequence:
MSRYVKYFVQAKRLDKRKRKYYKLDFLELNKELSIPHPLREQNQPKRLDLSKYLNIEVGDLVKVLYGPDKDKEGLVLSINPKRNTVTVDGCNMKKSAWNVTDNKKGSIITQEMPIHITNVSLLDPISKKPTVVKRRYMMNGECVRISKISGCAMPEPVHKNILKEQNNYERFMHKKKIGPPIKDIYAEKDYKNFNLLKKIAYEIKKKRFYDMKNFFKKDDKVENATD
The following text describes a protein:
Function:
High-affinity transporter for external inorganic phosphate.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAFGSKILNIGSKSDEYNDDAVPLDQVEEGAQERRYYLGLTKREFKLMMLAGVGFFLDSYDLFIINLVTPIFEYLYWGGIEKGPTGKGHYPSGIRGLVNASANIGNIFGQLLFGFMGDFFGRKFVYGKEMVIVIIATVLVIAMPKSIHSPLSKMMWVFCWRWLLGVGIGGDYPMSAAITSERSKIKRRGTLISLIFAFQGFGTLAGAIVTIILLGCFEHPLNREGHYHKLEGVWRLQFGLALVPAIGVLIPRLIMKESKSYENSKALNSAEGKDPKAFFNTDDEDNMKKSSSHGDSEVVEASDRYANQADAADAEVDNIEKQFAAVTTPENSSGFITYFRQWRHFKHLLGTSVCWFLLDIAFYGVNLNQSVILKNIGFSTGTNEYRTLMKNAIGNLIIAVAGYVPGYWFNVFLVEILGRKWIQLQGFVITGLMFAILAGRWNEISTGGRFACFVIAQLFSNFGPNSTTFIYPAEVFPARVRGTAHGVSAALGKCGAILASLLFNFLTGVIGYGNVMWIFCGCMWGGILFTLLLPETKGRDADEIDRLELFYGKDGKVQCDSKWKSWYFNGIF
The following text describes a protein:
Function:
High affinity transporter for glutathione. Also transports tetra- and pentapeptides like the opioids leucine enkephalin (Tyr-Gly-Gly-Phe-Leu) and methionine enkephalin (Tyr-Gly-Gly_Phe-Met) across the cell membrane.
Miscellaneous:
MISCELLANEOUS: Present with 2870 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSTIYRESDSLESEPSPTPTTIPIQINMEEEKKDAFVKNIDEDVNNLTATTDEEDRDPESQKFDRHSIQEEGLVWKGDPTYLPNSPYPEVRSAVSIEDDPTIRLNHWRTWFLTTVFVVVFAGVNQFFSLRYPSLEINFLVAQVVCYPIGRILALLPDWKCSKVPFFDLNPGPFTKKEHAVVTIAVALTSSTAYAMYILNAQGSFYNMKLNVGYQFLLVWTSQMIGYGAAGLTRRWVVNPASSIWPQTLISVSLFDSLHSRKVEKTVANGWTMPRYRFFLIVLIGSFIWYWVPGFLFTGLSYFNVILWGSKTRHNFIANTIFGTQSGLGALPITFDYTQVSQAMSGSVFATPFYVSANTYASVLIFFVIVLPCLYFTNTWYAKYMPVISGSTYDNTQNKYNVTKILNEDYSINLEKYKEYSPVFVPFSYLLSYALNFAAVIAVFVHCILYHGKDIVAKFKDRKNGGTDIHMRIYSKNYKDCPDWWYLLLQIVMIGLGFVAVCCFDTKFPAWAFVIAILISLVNFIPQGILEAMTNQHVGLNIITELICGYMLPLRPMANLLFKLYGFIVMRQGLNLSRDLKLAMYMKVSPRLIFAVQIYATIISGMVNVGVQEWMMHNIDGLCTTDQPNGFTCANGRTVFNASIIWSLPKYLFSSGRIYNPLMWFFLIGLLFPLAVYAVQWKFPKFKFAKHIHTPVFFTGPGNIPPSTPYNYSLFFAMSFCLNLIRKRWRAWFNKYNFVMGAGVEAGVAISVVIIFLCVQYPGGKLSWWGNNVWKRTYDNDYKKFYTLKKGETFGYDKWW
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLVRYELRSEYELANRELYRSAPKNDPEAILEGVSMVSLVGIVRQLGDLAEFAADVFHELHEAVMTTASRSHDLVVRVSQLEGELPALEKAILSRKTNPLQFPYAPGLEWHASIRNDQNLCTQGDLPRFIRSSYEECRGPPRLFLLDKFDVGGVGACLKRYTDPSFFKMEWASSEIMKAEKAQQDKKARRSKKPRRRKEGEVKDSRPPPVQFQHPRARYSTISVSSVDGLSESATTPLTNMAVESDPSSKPFPFVTFLGGSQQSSKESTVSLSGKSPMSVRKSVSKPVAAADKEEEDRVFKENSSKTIEGDTATRKEEKVDDAASDTEQFLDAMTTMESETDSEPREKRGLSNFRQSKVVRTKKAENDEDAPFEDARNLAIDSETEAESKYSLDLTPISVEPRSPVHHENVQLSYEVMNVENDAKVDVDRPDEVPDHPNISEDLRLEYEDRDLTDDEGEYPEKDLPPEDENRLEYPEEEDFEVESRTTDMNDVLELENEERKLLELHQDSSGVVEDVNRATSPAKAASRTSIEKDVNEGDDLVDEAALASDKDYIEESPDDEGAALESTEISDAEVDKQKAEETEEQKITSELEDEEPFDVEVIQVIGDNGDTKKEVEFEPLLASDDEGTIEDNEKREDEADDHGERLSDTKANVHEIADTSDAPRQTETVTREESANFLHIIGLENVQTKAAPALERNESLQASSPMDVFESASSQENFFSEEISSRFSAFSDENNTPNNELEVEELYSMHDGYSADDDSMRNGHSEAASELHWTPAGSTAPSGDGKLEIQQQNEAERDLSKDGKESDEREGSTVDVNQQLLSRLHDLSAQQHEDELVHSLPSDGKAQGNEIGNHKVDSDDDNEVDLEQDVEEHQQHAESTISSSRQLEEIERPTSQQASPKLQAFDTSKSDGDAIWAAEDNTSDKSEESLSSSPRSPVFGVLSPAKSADSLESEVATILAPSSPTSQSMPSPMPEEMPPLPPLPPLRWRTSLFMPRDSGLFQREPPSLEVGAGDHLASAHEPPPQVLVASETSPFQAVESPEPQPLEDTIDRISSQPETLVDKPLPDLHLPDPEPPSQPSSFLSRSIDVDNLEQHPSSQSLANKNISNDDPADAIPVSTMDEFREEAESQEPSDPETSPRTVPLTVADVPPALLVDDSQSLAATGLSHPDDKTCPDAAVHESLVPPPADDNEVPTIASAREDLSHLDDSQPLMEVSVFAPASPLTEQLPGPGPVAEARGLPESSLPPQCHSPTDASESPQAPSSPRTIDDLREASVPPQSHSPGTIDDLREVSVPPLSHSPTAARDSPQAPWSPGTIDDLREASVPPQSHSPGTIDDLREVSVPPLSHSPTAARDSPQAPWSPGTIDDLREASVPPQSHSPGTIDDLREVSVPPLSYSPTAARDSPQAPWSPGTIDNLQEVSVPPQSHWPTAAKESPRAPSSPGTIDDVREVSVPPRSPSPTKEFPDASSPVQAAQTQPQSPVRTEVSIPLQGPESFTASRDSPEALVPHPVGEQSVDPPEVLKSPPSRPVDDSPTPPPLRGNLDEEPETFPADAPSPSRKDLPGDALIQAISVHDRTKLKRVPSDVPGVPKAPDEREVLLEQIRSQSFNLRHTIVEKKEIKETTPRLVTNINVAAILEKANAIRQSLADSEDEEDDWSE
The following text describes a protein:
Function:
May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MRLTGPWKLWLWMSVFLLPASTSVTIRDKTEESCPILRIEGHQLTYDNINKVEVSGFDLGESFSLRRAFCESDKTCFKLGSALLIRDTIKVFPKGLPEEYSVTAMFRVRRNAKKERWFLWQVLNQQNIPQISIVVDGGKKVVEFMFQATEGDVLNYIFRNRELRALFDRQWHKLGISIQSRVLSLYMDCNLIARRQTDEKDTVDFHGRTVIATRVADGKPVDIELHQLKIYCSANLIAQETCCEISDTKCPEQDGFGNIASSSVTAHASKMSSYLPAKQELKDQCQCIPNKGEAGLPGAPGSPGQKGDKGEPGENGLHGAPGLPGQKGEQGFEGSKGETGEKGEQGEKGDPGLAGLNGENGLKGDLGPRGLPGPKGEKGDTGPPGPPVLPGSLGIQGPQGPPGKEGQRGRRGKTGPPGKPGPPGPPGPPGIQGIHQTLGGYYNKDNKGNDEHEAGGLKGDKGENGLPGFPGSVGPKGQKGEPGEPFTKGEKGDRGEPGIIGSQGVKGEPGDPGPPGLIGSPGLKGQQGSAGSMGPRGPPGDVGLPGEHGIPGKQGIKGEKGDPGGIIGPPGLPGPKGEAGPPGKSLPGEPGLDGNPGAPGPRGPKGERGLPGVHGSPGDMGPPGVGIPGRTGSQGPVGEPGIQGPRGLPGLPGTPGTPGNDGVPGRDGKPGLPGPPGDPIALPLLGDIGVLLKNFCGNCQASVPGLKSNKGEGGAGEPGKYDSMARKGDIGPRGPPGIPGREGPKGSKGERGYPGIPGEKGDEGLQGIPGIPGAPGPTGPPGLLGRTGHPGPTGAKGEKGSHGPPGKPGPPGPPGIPFNEGNGMSSLYKIKGGVNVPSYPGPPGPPGPKGDPGPVGEPGAMGLPGLEGFPGVKGDRGPAGPPGIAGMSGKPGAPGPPGVPGEPGERGPVGDIGFPGPEGPSGKPGINGKDGIPGAQGIMGKPGDRGPKGERGDQGIPGDRGPQGERGKPGLTGMKGAIGPIGPPGNKGSMGSPGHQGPPGSPGIPGIPADAVSFEEIKKYINQEVLRIFEERMAVFLSQLKLPAAMLAAQAHGRPGPPGKDGLPGPPGDPGPQGYRGQKGERGEPGIGLPGSPGLPGTSALGLPGSPGAPGPQGPPGPSGRCNPEDCLYPLSQAHQQTGGK
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Miscellaneous:
MISCELLANEOUS: There are 3 genes for eS4 in S.pombe.
Subcellular Localization:
Cytoplasm.
Sequence:
MVRGPKKHLKRVAAPHHWLLDKLSGTYAPKPSPGPHKARECLPLIVFLRNRLKYALNGREVKAILMQRLIKVDGKVRTDSTFPTGFMDVISVEKTGEHFRLVYDIKGRFTVHRITAEEAKYKLCKVKRVQLGAKGVPFLVTHDGRTIRYPDPLIKVNDTIKLNLETNKIESFIKFDTSAQVMVTGGRNMGRVGTIVHREHHLGSFEIIHVKDALDREFATRLSNVFVIGETGKSWISLPKGKGVKLSITEERDRRRALKGLA
The following text describes a protein:
Function:
An alpha subtype methylase, recognizes the double-stranded sequence 5'-GATC-3' and methylates A-2. Also acts on 5-hydroxymethylcytosine (hmC)-containing DNA, the normal base in this virus. May prevent degradation of viral DNA by the host restriction-modification antiviral defense system (Probable).
Sequence:
MLGAIAYTGNKQSLLPELKSHFPKYNRFVDLFCGGLSVSLNVNGPVLANDIQEPIIEMYKRLINVSWDDVLKVIKQYKLSKTSKEEFLKLREDYNKTRDPLLLYVLHFHGFSNMIRINDKGNFTTPFGKRTINKNSEKQYNHFKQNCDKIIFSSLHFKDVKILDGDFVYVDPPYLITVADYNKFWSEDEEKDLLNLLDSLNDRGIKFGQSNVLEHHGKENTLLKEWSKKYNVKHLNKKYVFNIYHSKEKNGTDEVYIFN
The following text describes a protein:
Function:
Could be involved in the export of 2,3-dihydroxypropane-1-sulfonate (DHPS).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSHITTEDPATLRLPFKEKLSYGIGDLASNILLDIGTLYLLKFYTDVLGLPGTYGGIIFLISKFFTAFTDMGTGIMLDSRRKIGPKGKFRPFILYASFPVTLLAIANFVGTPFDVTGKTVMATILFMLYGLFFSMMNCSYGAMVPAITKNPNERASLAAWRQGGATLGLLLCTVGFVPVMNLIEGNQQLGYIFAATLFSLFGLLFMWICYSGVKERYVETQPANPAQKPGLLQSFRAIAGNRPLFILCIANLCTLGAFNVKLAIQVYYTQYVLNDPILLSYMGFFSMGCIFIGVFLMPASVRRFGKKKVYIGGLLIWVLGDLLNYFFGGGSVSFVAFSCLAFFGSAFVNSLNWALVSDTVEYGEWRTGVRSEGTVYTGFTFFRKVSQALAGFFPGWMLTQIGYVPNVAQADHTIEGLRQLIFIYPSALAVVTIVAMGCFYSLNEKMYVRIVEEIEARKRTA
The following text describes a protein:
Function:
Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes.
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Localized to the synaptonemal complex lateral elements in late diplotene oocytes, while it is absent on the synaptonemal complex of leptotene, zygotene, pachytene and early diplotene oocytes (By similarity). Localizes to centromeres in dictyate oocytes (By similarity). Detected in nuclear granules and sizable aggregates.
Sequence:
MQAKNKDALQPIKEDRTGKAQDDAFWLQSLITDAFHDKGFQKIKEYFQQKESHFPQKYNRLLLYRLDRSINKELDKNEFQSVSLLLKCIQRFLVDGLKEDEPLLIRQGLIPKLVSWFERTTGILTSEGLASDTSLICVIEDFFDTALIISRSSSEGKIQMLDSFLLSLGFLVTEKTVNHLLQQEGLKTFNCILHAVPREERKKFPLSEGMCHLMKDLARTLLTVGDYDQQVAISEALCRLTIKKSRDELVHKWFDDEVIAEAFKEIKDREFETDSRRFLNHLNNRLGDQRRVYSFPCIAAFADEHEMRKPADEKLEKFWIDFNLGSQSVTFYIDNAENTLWDSVTLPKEAVMNFSITETEKIKIFIIYLKKPMIISYKEVMKIEIHFDLQFNISQVSIQALGEDKQMLPDQTKISSELFSKSDKEDRESPSGLERETEQAEESTNMVEFMSAEDDRCLITLHLNDQSEPPVIGEPASDSHLQPVPPFGVPDFPQQPKSHYRKHLFSESNQDSSTSELSWTSNQKKKSLKSYSSRKKTRTRSNLRILPVFPPSSGSGHEKDQAKLLSPSEKEIPEQNNTTSPKTSEQKFQDSFAFLTAEDSAQKTELQDPHSLSELSSLKHSEDEEKPKIVNQESLTESTSLKHKLRNLEDKDIPEGSFAKSQQSRLEEEVAPGSPFSITEERELPEGISTSSLEVVPENLNGSAILPTFENFTKKRKRKYELRYRKRPFNSENAKKAPDCLIKLLNQMQLFRLNKLERFQNLVLQELSSLKQDIQALEHLEKEVLEFWGKQSADLQSFCDLQVLRFNSTQTS
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
SGSSSVAAMKKVVQQLRLEAGLNRVKVSQAAADLKQFCLQNAQHDPLLTGVSSSTNPFRPQKVCSFL