lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Subcellular Localization:
Chromosome, centromere. Nucleus.
Sequence:
MIATPRRGEMPFQAVFLSSIPAGTLTPLKDLRCRGNSALCPPARPAPGPVLQSTLLEGGAGAREPLEISEIRPGPGPPPPKRRAREPPAQQSPAAAFLRMKMKTRAGGGSDRILTPGGPGPRVAGGGQRRAAEPPRRELPCIRIPQNQAVKMLNVDPIVLESPQKFFLRVKQKLQQKQQQKDPTFSSPNKQNIRPPPAAEKPVVKSAFGELLPNAQTEHVATNKDNEDNFLVESMDADDEMSLNTVTSTVGFHSTPPDPGDQLERRCGNREAKRTELQQEKRRLQPGDQRAEHRAEKILETATQKPSQHFCNVVLSTPEACMPRKEKQKENCNGPLDKPQADQIAVAAEKEKRICLSSWRIKVMNGNTAICVEGKRKDMKDMLWHSNAVVERVAHNQVKTSSGNIYLLQGNIDSVSMRKEGFSYQFTKRFTSGFSKRWKEYVEEFLRGLRRKERKKKMGEDENEERDSVVDTDKVQSAEDSARNVRKRETRNTTYEVLSRKDEHTYQTPKHKPILNSSNGIYTRSGRLVKPPLSFWCGEREFVDRELNVTIQKGGTDYLSMMYSTENPKRKTSSLSKLKERKDSTKTVEEKTKGQDKGNSEEKRIKTKNKATSTGSREARCFISDDENDHASDINKIKVWLSNKETHLNTGDRNKRDYNSRNMGTRKEKTGKEYGEMATGQNMYSLRSAKKPFQGKPLTEEFSSKDGEEESSDYIQLTVKRKNKPFLPKEIQNSESSSTCERLQGSTSEVSSGLQADTRCTAASHTMQLRQRIPAFIESSDSSEGETSSGEEYHAKEKRSEVSNKKAKRDVCNTTKPSTGKPSESKGDKVHKTLDFFSKAADDWSQKELQKLHRAVASFPKHKNGFWVDVAMAVGSRSAEDCHWKYTEEQAKASKRPAVKKTTSGKPEQKDKAEPVAITAKVGTFKRKQQMRDFLDNLPKDDHDDVFTATPFQNRRVRLPTFLGSHDEEEDDDDDFALTNNPITPSSAVFPLAKTPQCEHISPGMLGPINRKDCDRHVFRMQKTQGCRSSWDNVKKQQAAALHGTPASSRTKSTFGKKVQQNPAVGKLFVAEAADTSEEEQEDSYFSV
The following text describes a protein:
Function:
As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
Subcellular Localization:
Nucleus. Note=Localizes to DNA repair foci after DNA damage.
Sequence:
MSKSGFGSYGSISAADGASGGSDQLCERDATPAIKTQRPKVRIQDVVPCNVNQLLSSTVFDPVFKVRGIIVSQVSIVGVIRGAEKASNHICYKIDDMTAKPIEARQWFGREKVKQVTPLSVGVYVKVFGILKCPTGTKSLEVLKIHVLEDMNEFTVHILETVNAHMMLDKARRDTTVESVPVSPSEVNDAGDNDESHRNFIQDEVLRLIHECPHQEGKSIHELRAQLCDLSVKAIKEAIDYLTVEGHIYPTVDREHFKSAD
The following text describes a protein:
Function:
Component of the mitochondrial large ribosomal subunit (mt-LSU). The mitochondrial ribosome (mitoribosome) is a large ribonucleoprotein complex responsible for the synthesis of proteins inside mitochondria.
Subcellular Localization:
Mitochondrion.
Sequence:
MNFQRTVVKNCSLCLCFSVSICCWTISIDCPPFRQMLRRAVARLNTAVDDVIRRTLGAPPPLAPAMALAAPSASDASSAPHAAAALGSWTVADMAEQMRTLWGVPKYRTSHPKKQTRKFAYTRLLTPIEDVTTCEQCGEKHEVHTICGSCYEKVRLLTNMIKERMLAYNPYKGERPPKEVEVRFSDEQIRAEQERVEEEKKGEIKDGVRVVELEQPRPSWFRRVERQP
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
Sequence:
MDPAKAQMVADLEIEMMTDLYNRLTVACQKKCISPKYKEGDLTKGESVCLDRCVAKYLEIHERIGKKLTSMSMQDEKLMNQLQGQKTGN
The following text describes a protein:
Function:
Satiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.
Subcellular Localization:
Secreted.
Sequence:
MESSRVRLLPLLGAALLLMLPLLGTRAQEDAELQPRALDIYSAVDDASHEKELIEALQEVLKKLKSKRVPIYEKKYGQVPMCDAGEQCAVRKGARIGKLCDCPRGTSCNSFLLKCL
The following text describes a protein:
Function:
Binds nucleotic acids in vitro.
Subcellular Localization:
Nucleus.
Domain:
Contains a PAM2-like motif, which seems to be involved in the binding to the PABC/CTC domain of PAB proteins.
Sequence:
MAVIESVGANTTVEAGGLISPSPPSSVTSQESGASSNNDHGGNGIHDEIGVHVARSDGGESFKRDMRELHELLSKLNPMAKEFIPPSLTKPVVNGFNGGFFAVNNGFVAAGNFPVNEDGSFRRKKSFGQQGKRRMNPRTSLAQREEIIRRTVYVSDIDQQVTEEQLAGLFIGFGQVVDCRICGDPNSVLRFAFIEFTDEVGARTALNLSGTMLGFYPVKVMPSKTAIAPVNPTFLPRTEDEREMCARTIYCTNIDKKLTQTDIKLFFESVCGEVYRLRLLGDYHHPTRIGFVEFVMAESAIAALNCSGVLLGSLPIRVSPSKTPVRSRAIPRHQMH
The following text describes a protein:
Function:
Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'-repair diesterase and ribonuclease H activities.
Sequence:
MKFVSFNINGLRARPHQLAAIIEQHQPDVIGLQETKVHDDMFPLEDVSQHGYHVFYHGQKGHYGVALLTKEQPLAVRRGFPSDEEDAQRRIIMADLATPQGTLTVINGYFPQGESRDHPIKFPAKARFYADLQRYLEEQLSPEAQVLIMGDLNISPTDLDIGIGEDNRKRWLRTGKCSFLPEEREWLERLQNWGLVDTFRAANPDCNDHFSWFDYRSRGFDENRGLRIDLLLASQPLAARCIATGIDYAIRGMEKPSDHAPVWSEFSL
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Nucleus.
Sequence:
MAAAVRQDLGQLMNSSGSHKDLAGKYRQILEKAIQLPGAEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVTKNLYCDPPHFSVLLQQNI
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site.
Sequence:
MIKSPLDSFGEWTDMSVFLELKPRNDLASLFVDVPPGFREKAEVPEQQNPRKIKYSDINVVNVTDNFIRIGAPPTPETIQKRHKEAQNQQNQPKKQRERSQSTSSSAPSSPTKKMQKKSKKGEKSFDFKATRFGAAVRDVVIKPQTLCSPAFDDSTGRIFMAKVSVEPLSGPLVPKTAHRLAVDVNKLEKLEEFSAKAVPRVKCARCKLGILSEEYIMTVGCLPDDEFLATTQSADFYCRDSCGAGCDPDRHKHKKAEDLKANPKWLPTEKRAMISYANSILHKSSVLEENIVIDERKNIKCAGCKCQLGKVQKNHPDIYQFNQIATLMTGGPKKTPFVDKINPTQLSIYMAQLILNGCETQTSMKLVIRSLDKVPYMLVWLLDSYVVIANGILEGLRSEDDEGAILTPFPAIKLLYKVFNNQTAASDPRANGEDTSVGLIDLPLPCCEVLIELLLRSSLRSPPACRAVGQFFVGYLQIDERI
The following text describes a protein:
Function:
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular Localization:
Mitochondrion intermembrane space.
Sequence:
MVDEVEEEVHAMVVQEPEVVEALEVTKVHPVLESEPRVDEVLVVNETPVVPEIQEPEVKGVGATVVLKEQETNSGNVVVKDSDEALPSQEVAGVHTTDRGTIEEGLIDRMNSIDDRMNSRAASTPPARTKCAQCHTVERGGAHRQGPNLHDLFGRQSGTTIGYAYSTANKNMAVVWEKGTMYDYLFNPKKYIPGTKMVFPRLKKPKERTDLIAYLTY
The following text describes a protein:
Function:
Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis.
Subcellular Localization:
Cytoplasm. Early endosome. Endosome. Recycling endosome. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MSRHKSKKLIIEDDEPKQDELNPFSFKEFIRNKNQPSCSTEATEVYNGACLVEQDYNTSIDFATKGPFFTDPSALCQPPESEPDETWIESHQRSAIEGSPDFELCGASDISAYSEQSSLCSDEREAAEWELGQSDFLPKKHLSRISTGSYEGDEETSVIDISFHHKRGNAENGTKNLQQLREENSLLRKQVKELVRMSETDSRRIKQLTDEMHNKKLQEEKEANDLEAMVQSVEQNLQLMTKRAVKAENNISKLKQEMLKLQGQLEDYKSENERLRLGETAALATMRHNAQVASEYLNKAAQDAEISINSC
The following text describes a protein:
Function:
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine and small amounts of phosphatidylethanolamine from the lumen to the cytosolic leaflet of the trans-Golgi network and ensures the maintenance of asymmetric distribution of phospholipids. May be involved in transport from early endosomes to the trans-Golgi network (TGN).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.
Sequence:
MKSSGIAGDSNGFETNFLNETTNREEDGAFNWNAADDGTNERREDIHVRFQDSALPLGIDENELDEIDINGDSKKLDSVEVDESHDVNSPSDSRLKSSFKSVLELTANSMVSVLTPSTKTEQTSKGKGKKKKAHVSFLEGPVEEIPLDDIEPTSPREASPVFNGRPPIPPEFLKSRHKEFTIPNPLQFISNFLSNLFSRDTRYLKSSHGRIIIINPYDDSSQIDERTGKPYMQNSIVSSRYNKYNFVPLQIIAQFSKTANCYFLLIAIMQMIPGWSTTGTYTTIIPLLIFISIAILREGFDNYRRYRQDRVENRIQTQVLRHVDVDPPIVEEHSSFFRRRRWRRSRSQESASRSTIRSTDEREPERTSEDPPQLPPSPSSPSSPALSVKPNIDPQPPLYNSTLTTTRSIPANKPTFFWASCDRKDVRVGDIIRLTSDQTLPADVIALSSPNPNGAIYIETAALDGETSLKTRLVNSTLRSLCKDINDLIRLSGTCTVEDPNGDLYNFNGSMKLDSIQGEIPLSNNDVLYRGSNLRNTSELFALVIFTGEESKIRMNAVRNVSVKAPSMQKVTNRIVIFIFALVVSMAIYCTAAYFVWQKKVERKLWYLTNSKLSFVPILVSFIILYNTMVPISLYVSMEIIRVFQTFLVQSDIDLYYPENDTRCEVRSSSILEELGQVTHVFSDKTGTLTDNIMLFRNLSVGGFAWQHVGAENPKLVSTSQKSDDLDGEAKPPQLENIQGTTIQLLQYVHDNPHTTFSKRVRIFLLNLAICHTCLPSFDEENQIYKYQSISPDELALVHAAQQLGYIVIDRDIDSLTIRLHYPLDPHSHPIAKTYRILNIIEFTSKRKCMSVIVRMPNGRICLFCKGADSAIIKRLRLSNLAKRKDKSVTKAEQARKSIEIDKAIIRNSQSTSRPSLTASRPSLSRRRNDYINNVTSWLDERREKMGVVRPRASTSILETRRRPAVGRHSLAGGERLMEDKKYLSKQEEAEGSIYESLNHNDAKLFENTFEHVHAFATDGLRTLMYAHRFIDESEYQSWKLVNDAALNSLSNRQQLLDEAADLIEKDLEFAGATAIEDKLQVGVPESINSLFRAGIKFWMLTGDKKETAINIGHSCGVIKEYSTVVVMGSLDGVEGSDETVSGGQRLSLDRPPTNDPASLMIHQLISCMNAIHSNSLAHLVIVIDGSTLADIENDPELFLLFINTAVEADSVICCRSSPMQKALMVQKVRNTLEKAVTLAIGDGANDIAMIQEAHVGIGIAGREGLQAARSSDFSIGRFKFLIKLLFCHGRWSYVRLSKYILGTFYKEQFFFLMQAIMQPFVGYTGQSLYESWGLTCFNTLFSSLCVIGLGIFEKDLSASTVIAVPELYQKGINNEAFNWRVYFGWCSIAFIQAFLVFYVTYSLFGMKELNDNNIFAYGQLIFTAAIFIMNFKLVFIEMQYINIISIIVLVLTSLAWFLFNIFISEHYPDKNLYLARSQFLHHFGKNPSWWLTMLFVMVCALTIDIVAQMLRRTLRPTDTDIFVEMENDAFVRSRFEQESGEFLQANAPSVDEIEQYLKSRD
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MQLEKRNSTPNLMSHCGELPTTTSASNGLSEKLKYLETLISKSHHIRSSPYLLSIQQQAAMMNSDSITHFTFDPTVAKDLGNNAMLLAHVAPSWTKLMVKSIQFAKRVLVTLWELYQRKVWFDEKTANAICTAMGIKTEALSFLLENKKQIIEIDDSDSDDEPTESPQAIILDKSEKLSSTNFMSCDGKLMVAEALGGRSEKLNLQTLQSKVERDPIGYILEVLLIHSQFNSSLQLFQQAAMNFISVNGIIDSDLTTVASDPTVAEDLAERAMFLTLVAPSYPTLFFLADFPIRLVYLLHSFAQFIPSMSRFKLAHALILLVNRQTVAIDETLPLLMELQTLGDKKLTRFVSQHLVVNIRRLKRPAVIKTQKLQSVMFKMLQEENEAVAKRVLVILWRLYQRKVWFDEKTANAICTASFHPALRYPFFFSSRLRLYHSLQVVEKDCDDSDSDDELPHLKENHRDLTMYQLRKLGNRLPYNRKSLQKPLAERINNDYYSPLNHMIDRQGFAEKLFSCLQTYNEESEVKMMMLKFIARIVGRHKLALLEFYPFVQKYIHPHQQDVVNLLAAVVEACHDEVFTAGLNAVREICIRMPLVTTAISYSFENISI
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MDLFPTNVTPKNVTPVDSLSPRINNSMVKELETAQLTLFYNGEVIVLDDFPAEKVEELKSFASTLKLGLQLFLIGFSHLPDHKFYFFKDMVIARKASLLRFMEKRNVRVSAKSPYQRSDFDSAPKKTY
The following text describes a protein:
Function:
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MEPPGPSTPTASAAARADHYTPGLRPLPKRRLLYSFALLLAVLQAVFVPVTANPAHNRPAGLQRPEESPSRGPCLAGQYLSEGNCKPCREGIDYTSHSNHSLDSCILCTVCKEDKVVETRCNITTNTVCRCKPGTFEDKDSPEICQSCSNCTDGEEELTSCTPRENRKCVSKTAWASWHKLGLWIGLLVPVVLLIGALLVWKTGAWRQWLLCIKRGCERDPESANSVHSSLLDRQTSSTTNDSNHNTEPGKTQKTGKKLLVPVNGNDSADDLKFIFEYCSDIVPFDSWNRLMRQLGLTDNQIQMVKAETLVTREALYQMLLKWRHQTGRSASINHLLDALEAVEERDAMEKIEDYAVKSGRFTYQNAAAQPETGPGGSQCV
The following text describes a protein:
Function:
Catalyzes the irreversible oxidation of L-lactaldehyde to L-lactate. Also shows high activity with glycolaldehyde and L-glyceraldehyde. Has weaker activity with various aldehydes such as methylglyoxal, propionaldehyde or benzaldehyde. Involved in the degradation of lactaldehyde produced during metabolism of L-fucose and L-rhamnose. It may be involved in several other metabolic pathways.
Sequence:
MSVPVQHPMYIDGQFVTWRGDAWIDVVNPATEAVISRIPDGQAEDARKAIDAAERAQPEWEALPAIERASWLRKISAGIRERASEISALIVEEGGKIQQLAEVEVAFTADYIDYMAEWARRYEGEIIQSDRPGENILLFKRALGVTTGILPWNFPFFLIARKMAPALLTGNTIVIKPSEFTPNNAIAFAKIVDEIGLPRGVFNLVLGRGETVGQELAGNPKVAMVSMTGSVSAGEKIMATAAKNITKVCLELGGKAPAIVMDDADLELAVKAIVDSRVINSGQVCNCAERVYVQKGIYDQFVNRLGEAMQAVQFGNPAERNDIAMGPLINAAALERVEQKVARAVEEGARVAFGGKAVEGKGYYYPPTLLLDVRQEMSIMHEETFGPVLPVVAFDTLEDAISMANDSDYGLTSSIYTQNLNVAMKAIKGLKFGETYINRENFEAMQGFHAGWRKSGIGGADGKHGLHEYLQTQVVYLQS
The following text describes a protein:
Function:
Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Along with RAD1 forms an endonuclease that specifically degrades single-stranded DNA.
Subcellular Localization:
Nucleus.
Sequence:
MNNTDPTSFESILAGVAKLRKEKSGADTTGSQSLEIDASKLQQQEPQTSRRINSNQVINAFNQQKPEEWTDSKATDDYNRKRPFRSTRPGKTVLVNTTQKENPLLNHLKSTNWRYVSSTGINMIYYDYLVRGRSVLFLTLTYHKLYVDYISRRMQPLSRNENNILIFIVDDNNSEDTLNDITKLCMFNGFTLLLAFNFEQAAKYIEYLNL
The following text describes a protein:
Function:
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Sequence:
MDQSGVEPFTSKQAIPTNVVTFKGRRIPARIDPEARITYIVEVMAASFATEEHHITLCLRDEEDNLVTQNNLPSKVYNHDTLKLCASPTTEALIVVASLKSTRRRSLAESTPDTPPAEDVLPLKLALFNFQKFVSEEEFTAEFLLKGGMRTLVKILESENGLTGNTLAYALQGIRGVLEYESAWADLTDTFITRILLLLIYATQPNVLRPATAIIRKLVISRLSSSHHDNPPELLISASTKAPGLKPGLGPGPRHDVIGGKNRAKRKSRELTPAEKDQHHHYKGHSLYGFDKLYILIKQLNIVSSGEDEGSVANAEYLFKILVKRLEGTGDLELVAQSLGLINACLRSGNQEGSRQYNELVWILEKLGICRYVSRLIPTSTNNIISPHILDFQSRLCVILQHKRLRSVRPGQYKEHEKMLKDIWEAGKLGELAKKIGGEAGDGGWEAMSGGQLGMSTGAGLGAEPGTGMGKFGLGLGEIDRGVKGWWMIGLGEEDQDGVLGEGAMFRDVGELGLECLHWFATHEERFNNLVMEQQAKPAERRCPIGKASAECVKLLCEHYKISQAGTGHHAPTSFQLFLLNFPNLHHLVLKFFLRMWQESNSCTPDFYRLTHLIRSHLTLTLSPTTTSLIATTANTTRSSSSQTTSIDELLPELSKNWFHLEQDFLTTAYRTIRDRQMDFLEKEGGMMRRNAVRSLKKKLGKEVWDVVCEQRVGCMLQGGWFNAARLLVPGMVVMAKANPSKPLRFLRLSEDRKTIAWDDFEQRSGSPSFESLTHRIKISSISSVKQETSTPVNSRSPNLISKLSFSLISSLPTATGVTLEKSLLDLDAIHAAQLAEWSDGIKVLKDGGMTSQDSANYIQILTELALNIRLLDITGDGVEIPENVDIGPGQCIFLQRLFCKLNHG
The following text describes a protein:
Function:
Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
Subcellular Localization:
Mitochondrion.
Sequence:
MEQLCKRYVHTPAAFIQNIVANTKRTTLATQLSVEKAKKKVPKTALKKKLNSRPKERLPNWLKLNDVFNIHYEKPSNSDINKVNRFFNKAKVEFEWCAASFDDIPENPFLNKKSHKDILKDHGECGTTLIDTLPEVIFLGGTNVGKSSILNNITTSHVSRDLGSLARVSKTTGFTKTLNCYNVGNRLRMIDSPGYGFNSSKEQGKVTLQYLLERKQLVRCFLLLAGDKEINNTDNMIIQYIHEHGVPFEVVFTKMDKVKDLNKFKKKVMSSGLMDLPTLPRLVLTNSLTSSTSPKRFGIDLLRYVIFQSCGLIL
The following text describes a protein:
Function:
Plays a major role in the integrity and stability of the capsule.
Subcellular Localization:
Secreted. Note=Secreted via the ESX-5 / type VII secretion system (T7SS).
Sequence:
MTSPHFAWLPPEINSALMFAGPGSGPLIAAATAWGELAEELLASIASLGSVTSELTSGAWLGPSAAAMMAVATQYLAWLSTAAAQAEQAAAQAMAIATAFEAALAATVQPAVVAANRGLMQLLAATNWFGQNAPALMDVEAAYEQMWALDVAAMAGYHFDASAAVAQLAPWQQVLRNLGIDIGKNGQINLGFGNTGSGNIGNNNIGNNNIGSGNTGTGNIGSGNTGSGNLGLGNLGDGNIGFGNTGSGNIGFGITGDHQMGFGGFNSGSGNIGFGNSGTGNVGLFNSGSGNIGIGNSGSLNSGIGTSGTINAGLGSAGSLNTSFWNAGMQNAALGSAAGSEAALVSSAGYATGGMSTAALSSGILASALGSTGGLQHGLANVLNSGLTNTPVAAPASAPVGGLDSGNPNPGSGSAAAGSGANPGLRSPGTSYPSFVNSGSNDSGLRNTAVREPSTPGSGIPKSNFYPSPDRESAYASPRIGQPVGSE
The following text describes a protein:
Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MVTNVTNFSRSGLYDWMAQRVSAVVLAAYVIFLLGYLIAHPNISYADWHGLFSQGWMRIFSLLTLVALSVHAWVGMWTISTDYLTSMALGKAATVVRFLFQAVCGMAMFAFFVWGVQILWGM
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation (By similarity). Involved in the regulation of DNA damage repair.
Sequence:
MTGSFSVKLKSKKGQFIVNDLNEHTTLGELKTKIVQATDIEATQLHVLVGYPPKPLDLSQQQEQRALKAVGINSGETLIVEEKAAPAPAAPVPGGTTVEDDEALARRLQAEEEAQLLQETAGGPVAQAADYQLPVAPTESGPNGDFNGILLKKVVPADNSCLFTSIRFVLNGKVDNEGSEMMRHIIAQEVAADPQSYNDAVLGKSNAEYCAWIQKADSWGGAIEVSILSNYYGIEIDVVDIQNAIINRFGEDKNFGLRVFLLFDGIHYDPLYMETSPSAAPATIFPVEELGVYQQAEQLANEAQSSRQYTNVDKFTLRCMQCDVRLVGQVQAQEHAKQTGHKNFGEI
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLVRYEIRNEHSLANPQLYRTASKDDPEGLLEGVAMAGLVGIVRQLGDLAEFAAEIFRDLHEEVMATASRGHELMARVQQLEAEMPAVEKALLSETNQLRFAYTPGAEWHASIRNDQNHCTQGDLPKFIRNSYEECRGPPRLFLLDKFDIAGAGACLKRYTDPSFFRTEWASSELMKAERAQRDKRARREKKGRRRRNVDGKESIPVDQLHSRFNPEYSKELVPPGPDMLPRMWHLPVADRSEQALENLNYNPSIGFVAKQDSHAASHEYGRGGASSYSLHKQDSQNSIDGLQRLDSQNSGMSRLDSQTSMDPDRQHYEDEPTTSRHSGGLYRIRDADTGDVYSEEGMSRKWEDVDYSEDVIEEKPQPSRQETFKDSDEVASEGDQFLDALATMESEADSDSEPRTRHYADASSDRMSDLKDSNSNSPPRDEGRALGLDSRISSNENLSLREQQARGSLRGDSPGTVSSEKLDISKIVSPPLRVHVRRNSSDSSSSSSSSSSSSSSPSPRAGKQYEDFSQSHEVGHSSSFNSVTGVRVSKMVADIEKRTFEQIQADERLEKEREEELQREHQFKKEQERLQQIQLQLQQQREEELRQEQLRKEEARQEELRKEELRQEELRKEELRKEEARQEEIRKEQIRKAELEKERVRQEKLRMEQIRQEEFRREQQRREELRREQARLEELRLEQIRQQELRQKEEQRLLEERQKERKQEEERQRLIRVSVYSARKPQVEELTTRTLPPLSFHSSTPPSAPIEVEVPSPTSSRMSLSSGSSPDSPVFSALHSLSPIRTSRNILSSPESRPGFVTRPGYASELIMSPTSPVPILALAMSPTSRSGSPPPPPLEWPGMHFIDSPTLSPSNSFGRYEARSPSNSPKAHEVRSSSISPRKPEAKFSSVSSKEAEVEEASPVSQGEPLQVMKPSPIPPRELQLRPSATPLDLERRSRSSSPEEPRGRSRSSSPSPKQPEVTKTEFESSPSSWESERVQSSTLSKLPAERSPSLSPKEPEAASAFNRAQDPLFEAPSVSAKEPVSTQDISDVQKGESKPAVDAPEKREVVSVSSLSKEQDAEGTPVAESSDVPTTGPKPSSSSPSREPAEGASSKLKELEIPEDDLYEKETAKSASDDSDFSPPVSPSSSAEDFSSSVAVKILADFSSAVPSSENLAELASVSRAIFKKDLLLPQSESETESEPSPSDRQRHIEDNAFMPLPSKLSEVYPSASSTSYNDATPYNDAPSKSPSPSRSTAADGASSVRVPSPPPPPPPPVASRTALDPMLRSEHDLRSSPPFRKTEISSSALSSAQLPPLPPLKTANDLILSKAPSKSDSRSPASALSVPPAPTPPSKPLLDFRGSPSRSVSSLPTLSPPGSRPLHNLPPPTPPTKNQNQGGGGDFNPAPMSTRTLHELPHPPPPPSRTLHELPPPPLSAAKRGSTVADVQDALLEAITSHDRSMLKKVKTMQNPVVRKPDDRSHLLEQIRAQSFNLRHTVVEKVEPPPVRPTNSISVAAILEKANAIRQAFAGSDEDDDNEEDWSDIQKKE
The following text describes a protein:
Function:
[Cyclic AMP-responsive element-binding protein 3-like protein 1]: Precursor of the transcription factor form (Processed cyclic AMP-responsive element-binding protein 3-like protein 1), which is embedded in the endoplasmic reticulum membrane with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress or DNA damage, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus where it activates transcription of specific target genes involved in the cell-cycle progression inhibition; [Processed cyclic AMP-responsive element-binding protein 3-like protein 1]: Transcription factor involved in cell type specific DNA damage and unfolded protein response (UPR) (By similarity). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (By similarity). Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation. In astrocytes and osteoblasts, upon DNA damage, inhibits cell-cycle progression after G2/M phase by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus; [Processed cyclic AMP-responsive element-binding protein 3-like protein 1]: Nucleus. Note=Upon ER stress or DNA damage, transported into the nucleus.
Sequence:
MDAVLEPFPADRLFPGSSFLDLGDLNESDFLNNAHFPEHLDHFVENMEDFSNDLFSSFFDDPVLDEKSPLLDMELDSPAPGIQAEHSYSLSGDSAPQSPLVPVKMEDTTQDMEHGAWALGNKLCSIMVKQEQSPELPVDPLAASSAMAAATMATPPLLGLSPISRLPIPHQAPGEMTQLPVIKAEPPEMSQFLKVTQEDLVQMPPTPPSSHGSDSDGSQSPRSLPPSSPVRPMARSSTAISTSPLLTAPHKLQGTSGPLLLTEEEKRTLIAEGYPIPTKLPLTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEKKVETYTSENNELWKKVETLETANRTLLQQLQKLQTLVTSKISRPYKMAATQTGTCLMVAALCFVLVLGSLAPCLPAFSSGSKTVKEDPVAADSVYAASQMPSRSLLFYDDGAGSWEDGHRGALLPVEPPEGWELKPGGPAEPRPQDHLRHDHADSIHETTKYLRETWPEDTEDNGASPNFSHPKEWFHDRDLGPNTTIKLS