lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mediates the uptake of pyruvate into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MVLIFYLYCKCSNNNRIVQVCVFYSGMFMRFAWVVKPCNIHLLVCHMSNETVQLYQLSRSIRSQRGVLEGVQIAQTSWASLKDGPQEWGFLMIDFGVRWGFLMYTVVIFTSECTAYIRHLIFIF
The following text describes a protein:
Function:
Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates abscisic acid-inducible transcription. Involved in the regulation of plant development and tolerance to abiotic stresses.
Subcellular Localization:
Nucleus.
Sequence:
MEKEDNGSKQSSSASVVSSRRRRRVVEPVEATLQRWEEEGLARARRVQAKGSKKGCMRGKGGPENPVCRFRGVRQRVWGKWVAEIREPVSHRGANSSRSKRLWLGTFATAAEAALAYDRAASVMYGPYARLNFPEDLGGGRKKDEEAESSGGYWLETNKAGNGVIETEGGKDYVVYNEDAIELGHDKTQNPMTDNEIVNPAVKSEEGYSYDRFKLDNGLLYNEPQSSSYHQGGGFDSYFEYFRF
The following text describes a protein:
Function:
Acts as a receptor histidine kinase for the cytokinin SDF-2 in a signal transduction pathway that regulates prestalk gene expression and controls terminal differentiation of prespore cells. Binding of SDF-2 to this protein inhibits phosphorelay and induces rapid sporulation. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MELKTFKDLNDDIIGDTSPVINTGDQPNPLRTQQQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHHIPQQLYQKQQQQQHSHSYGNHSFIHNVSPTSPSYDINNNNNNNNNNNNNNNNNNNNNNNSNNNNNNNNNNKNNYNNNYYYSPIENSNISKSLEESVLNQFPHNFNLNSSNNNYLNNSSSLHNINQSVNSLSNNNNNQTNQQPINNNNNNNNNNNNNNSNNSNNSNNNNNGNNNNNITDSPTKSKRHSTYETNIGSHQRRKSIQSLIANSAIHSFSKLKNKPLSSSTPSTVNTCGAVNNNSNNNNNNNNNSTGSLGAIPMDRSFDGNINTITEESTGGNNSPRSNCGSNCGSNGGIPLSPRNLSSLNSGVNVSPRNIHLNNLNNNSSNLPPLSPRHINFHINVSNLNNNNNNNINPNNNPNNSNNSNNNVSPRNNNHNISPRGSNISPRSNNGGSTTISPRNISNNNNIINNINNNNILTPPRNSPRLENVNPTNSPRLLATSLNSTLPIVSSLTSSNNNNQSNNNTNPSINNNNGRNGHCIQTISEEILGNKPVVYNNGNNNNNNNTNNSTTSNNNITTNNNNNNNNNINNNVLSTPRKRTKGNHSKTNSLQDFETSSMNGGDDSISGAGSGGSLRRRNKDDNDENDGNSNNTNSNNSNNNNNNNNNSSNNNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNYHNGATMMMSHNHQSIGMSSSPKKNNFKPFSRNCSLMGMGRRAWAIILGLFIVGSSISILATLVLRYSEENSIADDFARVARDRFTMLRIEFNNRLYITQTLSLLLSVFPSTSEDQFVPFSKLWSDNAEGLEGIMWAPRVSNLDRYTWEIEHSVKIREIVTNPNNSSDMRDVPAAAASDYYPILFSEPQSSNDHFKGYNIYSDMWRRPSLNKTRDTGEKVSVASPYINKLANVPKNSRSNVLLYIYQAVYTYGKVLSTVEDRRHEVIGFASCRFFISRMVSASLQRLTEEDSLDLYVFDLDSTPIGELIYYRASNAGNDDGSSPTNIMNGKMLEDRSDMIYYNTMNVGGRNWMIALRPSRKFTNKHYTFYPYAIGGVCMLLSALVSFWFAVNTKHNIKLSATNEDLHKEIYNRKLAEKALAESQERLELAMEGSEDAVWDWKVNTGELHISSRWFQILKAHDTSYQSRTLYEELKSSSTNNLNFKGDSKNGGSNNGTFNLFKNGKVDSSSPQSITNVNTTNGGGGGELRKSNSGYLYNDELFSPIILEEMVSSPNTHQLAIWNMKFLAELIHPDDKQKFISEIKKTITRETSIMEIECRMRKKYGGYLYIIMRGKVVSNETSFKDNSLRMAGTLRDMTSRKDMQRLILEKEAAEEANKAKSAFVATVSHEVRTPLSGVIGVSDLLLETNLSEEQRDYVQTIQKSSQALLTIINDILDYSKLESRQLKMETLPFSIIETCQAVIHMLSVAANDDVDILLRVPPNVPRIIFGDAMRMRQVLLNLLSNAIKFTSRGHVLTDISVDDSIPPTNTEEEIIHLCITIEDTGIGIPQSLFDSIFEPFSQADNSTTRKYGGTGLGLSITKRLIEEVMGGTIQVSSIVGQGSKFKCIIPFLLPNTSPSDLNLISPSSLPKPFINRSPKSTYSFTDKKNSVPSTPIPSGDILINKVCLLICRDTVTELVFKEQLEWLGMIVKQVPRNVIDSIKNTILNNNNNNNNNNNNNNNNSNNSSSIISPSSLDYSDENEHLDLVLIDLEILTEHLKIPSNVPIIFITPTKFNISKHNGILNKWITKSPNQRVELIRRPAITDKLIPIISKCIKSQVQFTSGSSQLQSQQANLQQQLLHQQLCNNGQTLNNNYNSGGIGGGGGGGGSNTMNGSSGNLSNNNNFGQTPLSSGLVLLVHTGRTPPLFNNNGNSIIPPLELAVDHHGNQQQQLYQQQQQQQNNSSGNFQQFYQQQNNNSNNSFTPTLPNENSNNSIMNNSLNNNNTTPSNVTPTLFTSSPLDLQGRDTPVLQPPAYRKKALIVEDNELNRKVLAQLFKKIDWTISFAENGREALKEITGERCFDIVFMDCQMPVLDGFQTTKIIRSKERENNWKRMNIVALSAGSSSSFVQDCLDSGMDSFMGKPITLATLKDALAKWGGYNN
The following text describes a protein:
Function:
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.
Sequence:
MKFLNPPFPYSMTSDPESFGHECFTRRWGIILTGIEKDVSERLSKLASTSKDSEVVAQGKPLLNDLEAFKSDIKNDRPLVPLEGEGQDIVEYNEELKQLDNASWGNAPWLYSECYYYRRISLIFARYSEWKAYDPFFQQKDSTLKSSRAAVEELAGRYCLLEEELNSIAKKGDSHIAYMVFVEMAQISLWGNATDLSLLTNLSYEELQNLQGQKVVEESQKNILVNDFPTVWSKLKDVHNGRIDFVLDNAGFELYVDLIFAAYLLKAGIAKEIVLHPKDFPWFVSDVLPYDIEYLLTNLDTIFPTESVTKFATDLRSFSAKGQLRLRTDPFWTTAHYFGRMPDFAAGLLTELEKSDMIFFKGDLNYRKLTGDCLWPRTTPFGKTLGPIANAINACALRTCKADVVVGLPDGLYEKIAKDLPHWERTGKYAVVEFCPKA
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MRKPCYAVYHPALRLKCLVRKGLGKIKGDTDMCDKQQLKKKEKEKQRAQKVACGPRDPPCTFSRSYTDQKRKEIHLGSTEWGLKESFTLTRGPNRRGNVGKGVKRPMVNKKLGQLELTSLDLRWQKEGKGN
The following text describes a protein:
Function:
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.
Sequence:
MKIPERVENGLDMDPDGQVAVEGAVRTVAFCPCKWNSSLLAVGSSDRVTVFSLKFPDEGSDQGELAVEVVRRFAHKEPVCSVAWSPNMSLVLSPVCMRFATASSDGKVRIFCSNLQETDDMSVLDGHRGPVNAVAWEPHSGEAVASVGDDNACRVWGLDGEQRARLVLRSPGTAVAWHPDEAGKLLVAEKRGSLRLYNALSWQPLMSLDTGPQGAPLLSADWSVCNSLLLGAVAGPSWFLWETARSSRPLEQKAAYPGGGTDFRFSHVHEALCATRGFPGNQVRVLNLRTAQVLLTRDQPVGCGLSWHHKLPIVAYGGDGRVRLFRVTSS
The following text describes a protein:
Function:
Promotes cell proliferation.
Subcellular Localization:
Cell membrane.
Sequence:
MEIHYPGVRSPVQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQELLPYLEGGCWGQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQESRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVPPHGEPRPRMFFLFTDVLLMAKPRPPLHLLQSGTFACKALYPMAQCQLSRVFGHSGGPCGGLLSLSFPHEKLLLMSTDQEELSRWYHSLTWAISSQKN
The following text describes a protein:
Function:
Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons (By similarity).
Sequence:
MSKEIKKMEKKRNKALDAIDIKILNELQRNGKISNIDLSKKVGLSPTPCLERVKRLEKQGVIMGYRALLNPELLDAPLLVIVEITLVRGKPDVFEEFNAAIQALEEIQECHLVSGDFDYLLKTRVADMAEYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNFLVLK
The following text describes a protein:
Function:
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Membrane.
Sequence:
MFLPHLRQSAYSVFLKPFFLSLDPETAHELAKNFLGIGQKFPGFLTLMESMTSYQSDRLKTKIAGIEFENPLGMGAGFDKTGELYPFLSRMGFGHIEVGTITGQKQSGNPKPRVFRYPQDQALVNRMGFNNPGADSAEKIISSQKKTKIRGINAGKTKIVPEEKAVEDYVYTLKKLSPYADYAVINISSPNTPGLRNFQKQENFVSLIQGIRKDLGKNFKIPLFVKFAPDMETKELEALLETSLSLKINGVVLTNTTIDKSCLKNYPNVEKEGGLSGTPLKNRSTEFVRIAYRILKRRIPIIGVGGIDSEKTALEKILAGADLIQIYTGYIYQGPFLPMRILKFLDRFLEKQDLKTVSDLVGKEKEIRLDQK
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
Subcellular Localization:
Cytoplasm.
Sequence:
MLWARGRQPDHRIRMSQQTTIRKLAELVNTPVDKLLVQLAEAGMKFSGPDQVVTSTEKMKLLGFLRRTHGKADTPAEAASEAAKKITLNRRKLQEVTVNAGRTKTTVNVEVRQKRTYVKSENEGSGRAAPMTPDEERADILAKLAASRQRNLDEQQRLAESDRARDEAIQRKRDEEQAAKDRVEAERKAAEEAAAAASAPAPVAAAPAPSSAPAARAPSSPSSAPRPARPAGASPASRPATPARPDDRNNAAKHKTRGSHVMVAGVEDDDATKRFAGQLHLSAADRARRSNVRGKPTGRPGSSSSRRNDGGRGSNQSNSGPHGFERPTAPVVREVAIGETITVADLAQKLALKGGDVVKALFKMGVMATITQSIDHDTAALVTEELGHKAVRADNADFEDALLAHAEDAQGETTSRPPVVTIMGHVDHGKTSLLDYIRRTKIASGEAGGITQHIGAYHVETGRGVISFLDTPGHAAFTSMRARGAKITDIVVLVVAADDGVMPQTKEAVAHAKAAGVPLIVAVNKIDKAGADPLRVKNELLAENVVAEDFGGDTQFIEVSAKVGTGVDTLLDAISLQAEVLELKAVADGRASGTVIESSLDKGRGPVATVLVQQGALKRGDYLVCGIQYGRVRALFDETGHQPASAGPSIPVQVLGLSGVPEAGDDFVVVDDERLAKDVAQQRETKRRESRLVASATNRMEDILAQMGKGEGQQVLNLVIKADVQGSVEALKQSLVALSNDDIRINVIHSGVGGITESDANSAAASKATIIGFNVRADASARKIVESNGIDLRYFSIIYDVIDQVKQVASGLLGVEIREEIIGIAQVRDVFRSSKFGAVAGCMIIEGVVKRSKPIRVLRDSVVVFEGELESLRRFKENVDEVRNGTECGIGVKAYNDVKAGDQIECFERIEVARTL
The following text describes a protein:
Function:
Probable transporter of a GTP-driven Fe(2+) uptake system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MRLSELGTGEKGVIVKVLGHGGFRKRIVEMGFIKGKTVEVLLNAPLKDPIKYKVLGYEISLRRQEAEMIEVVSEEEAKKQAEKAVYHEGLPEDVSVKEEDMKRLALGKRRTINVALVGNPNSGKTSLFNLASGAHEHVGNYSGVTVDAKEGYFDFEGYHFRIVDLPGTYSLSAYTPEEIYVRRHIVDETPDVIINVVDSSNLERNLYLTTQLIDMNVRMVVALNIYDELESSGNTLDYHLLSKLFGVPMVPTVSKKNRGLDTLFHVVINLYEGVDFFDKQGNMNPEVLKDLTEWHDSLEDRKNHEEEHLEDYVREHKRKGRVFRHIHINHGPDLEKAIDAVKEEVSKNEFIRHKYSTRFLSIKLLENDPDIESFVRTLPNAGEIFRIRDKMAKRVQETMNEDCESAITDAKYGFISGALKETFTDNHLEQAQTTKVLDAIVTHRIWGYPIFFLFMYLMFEGTFVLGEYPMMGIEWLVGQIGDLIRNNMSEGPLKDMLVDGIVGGVGGVIVFLPNILILYFCISLMEDSGYMARAAFIMDKIMHKMGLHGKSFIPLIMGFGCNVPAIMASRTIENRKSRLITMLINPLMSCSARLPIYLLLVGAFFPNNASLVLLSIYAIGIFLAVLLARLFSKFLVKGDDTPFVMELPPYRMPTAKSIFRHTWEKGAQYLKKMGGIIMIASIIIWFLGYYPNHEAYETVAEQQENSYIGQLGRAIEPVIKPMGFDWKLGIGLISGVGAKELVVSTLGVLYVDDPEADEASLAERIPITPLVAFCYMLFVLIYFPCIAALAAIKQESGSWKWALFAACYTTGLAWLVAFSVYQIGGMFV
The following text describes a protein:
Function:
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MDSQLLRLNPPNNLSIKPFHSPNFPSFAAPSFIRLSSLSFPSATVTGPACKRIRCAMKSYKLPELSHVEVESLKARPRIDFSSIFSVIQPIVDDVRSRGDAAVRVYTEKFDKVELEKIVENVSELPYPELDPTIKEAFDVAYDNIYAFHLAQKSVEKSVENMKGVRCKRVARSIGSVGLYVPGGTAVLPSTALMLSVPAQIAGCKTVVLATPPGQDGNICKEVLYCAKKAGVTHILKAGGAQAISAMAWGTESCPKVEKIFGPGNQYVTAAKMILQNSEAMISIDMPAGPSEVLVIADKLASPVHIAADLLSQAEHGPDSQVVLVIAGEGVDLKAIEEEISKQCNSLPRGDFASKALSHSFTVFARDMVEAISFSNLYAPEHLIINVKDAEKWEGFVENAGSVFLGQWTPESVGDYASGTNHVLPTYGYARMYGGVSLDSFLKYMTVQSLTEEGLRNLGPYVATMAEVEGLDAHKRAVTLRLQDIEAKHSSSVR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGGKRTKGNTKPSSSGRSAELLGTSVPTLFGFAALDSTSMPVVPGFVQIDPNHSVDELDPNLDDTLQIVLRKMLKKDPTTKTKALLEFTELMNGADLEVVKAVLPFWPRLFVNLSTDAEHRVRETTQQAQAAIVRRAGKKIAPFLKQLAPAWISSQYDTYAPAASTALQSFSSAFPPGKVSEVFVFCEQEILDYYTKNLTIHTAITLSNPKSHTPEECENKYQRVLISSLRGYALYLSRIPPENLQKSADKNAELLKSPKFWTYHKHKTAAIRAAWFEVISALLQHAPFLVEQHQAQITTSVFQFLDETDPTVVTHVWSSIVLIQAHLAGWHTHLNFDKAVFPKLWKLLRSGGGGNAACVYPHMLPLVSGFTREVLGDERLAKFYSLFFESMNEGLKAVQSSRADVTAVSQAYYESFQYVVLQAVRDETMAEAAREEFCMNLLEQHLVGVIAWCITSEAACGKYVFQSMANLLDHWCQHSATHPLYVRLLVTFWERLYGVVKESVDCKDNAASITDAHVDLVQNLRRTSHKRVKFAVENPNAEDAVDGGSCPLTSGDHANRFENQLQLLVYRICQLYIAKISVERDDGYVLQLEYLVRAFQGRELFVFLAHDSENIKCLFDTFARWLQDAKLQSEYVVELIMILYKYLDADERAALLNKWIKMANKTVQSWIILRALSHPLCQEPNIKQFLSQPEVSSNIIECAVGVANGNTKDNMILLQKCFFVASNGEILIDAETCRRIIDTVTHPLRDASKQELHDGCISFLAQIMPVICSDGRLTELHRALFGTLFDFSVHNVVSEHLSEDTLWEATTAWQDALSGEDIELDGQLLARCVNTIDERLAALAGRADQADILVLLERVAELTAKLIACATESHKHDRPKRCQRIDAMLRELFEKRTVELQRQTDETAHLAEYTELLQGRLITKQSRLSTSPALSNEQFAVAMKSLLARALGAVSVVLKLSCKAKLKQQRPAKSEQADKMDVDERKDELEGEEMDVSENGDGNEEEDEELWILRSWSELIYEKVLSVIYLASVGDTVLYNTEQLESVVECLILAVQEKLSLLLRNVPQDIVQEIKRKLFTLSNEHGMLWAKCLNALLVIDQYADEENGPVLLYEDASTVANNSEDLVAYINIVQCLGAKMKPKCLPIGPNLFENYFDVLVKLASARCLIENHFSTNYNELNDRKIIGNCLIVLHELITRQAANKMLLYNCNLAQADENKIFLDMEVANLLTVVLRYFPSELDISKWDFIRIALSSWTLSVSKSFAHYHTHNISLFIAALFRLFNGLMQFFNAERQRSSTELLTNVIEEWDNVFSKDVNLVLLKAFVGIVNALDSGRKSDEYFIESICPYVEAIDFNHVLKANKVDSKTSLDDLITFSLTNIRHRNKRVRYAATAMLKSLSIGLVQRDQEQLLKRTESTERQQESGEEADDSWHLLERFRLPLDEYQDLLHEFVADFHYKPADQETATSVAEQEKLAEARSHCLSYLLLWDCILGICAKAPSELRSIYTSWISRNEFEELLLPVLFKLMPPELLRNPDSCAVYGQAMFASLEWNQIKNPNTKLERYACHLYAQTLRHLPVILRRWFNGLNHRYSTIVSKITANSVSGLLCQEEFQALLERKDRQDNMQIKVHSALRQVMAVYSIDEAKVELHITLPSNFPLGAVTVEGGKQIGGRLQSRQVVMQLSIFLTHQNGSINDGLSLWKRNLDRKFEGVEECYVCYSVIHQDTCQLPKLSCKTCKKKFHGPCLYRWFSTSNKSTCPICRHIF
The following text describes a protein:
Function:
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
Sequence:
MADAEDSRHSKNEGFPNTSLITEKLDLLDLFGSPKVKTEREGRPARLLEGLSAVNAETAFVKTHPLQHEWTLWFLKPPTQGLEWSDLLKEIISFKTVEEFWGIFKTISKASMLPAKSDYSYFLKGIRPEWEDPQNMNGGKWAYQSKHKGSNLDELWLYMVLAAIGETLDPTGKEVTGVVCNMRKGFYRIAVWTRNCNDKDVLEKIGLRFKEVLGISDKETIEYSAHEDSSKAGSMRAKTRMSL
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MASRITRLPYHQQRHLLATAAEASSHRLPRARGAIPKYTISEKFIFVHVKYNQLRDIFACLLPPLDGFSLKNSRWYMIKSSPSNPLTMRECRKVFPSLIRPSASYSTQASDQKTQKERKDLSTTEDPFDDAPTYNIPEKPVTFAEGASYSLVILAGLGIFGKALAKVQSDSQVTARIGYPITGYGSETRNRAARQRVPSRIWTDEEGVEHVEVNFYIRGPHGAGKVYSAMFKDNSDRSWKFTYLLVEFTAPHQGQVMLESYIPA
The following text describes a protein:
Function:
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MPDFLVRAAAGASTKSANKRAAAKASSDQPAPPVEPAAPRAPHPRKSGPPAPPPERFQKDAVQAVADTGFKDPHADREALRYAEPIASREAILQLLEDCDGPQTAEEIAEQLGLSDRIDALGKRLAAMVREAQLVQNRRGGYAPVQQTSLIAGVVIANPEGFGFLKPDEGGDDLFLPPFEMRKVMHGDRALANVTGIDRRGRREGAIARVLERRMSRMIGRFFYEHGVAYVDPDDKRVQRNVQIAPDGIGEAREGQLVVCELIAPPDARRPAIGKIIAVLGDKLTPSLVVEMAIHGHELPHEFPQEVLDEAAAVPLVVEPQMIGGRVDLRQMPLVTIDGEDAKDFDDAVYCEPNADGFRLVVAIADVSNYVRPGTPLDDEAQKRATSVYFPGFVVPMLPETLSNGICSLMPKVDRMCFVCDMQVGRDGEVTGSRFYEAVMNSHARLTYNQVWKAVGEDDADTKAFIGPLLPQVQRLHQLYNVLSKARTHRGAIEFETSEVRFVLDNTGEVTQAGMLVRNDAHKLIEECMIAANVEAARYLLSMHVPAPYRVHERPPESKYEDLLEFLKEFQLSLPAWSKVRPGDYTKLLKKVRARPDAALLESVLLRSQSLAVYSPENNGHFGLALEAYAHFTSPIRRYPDLLVHRAIKHALTGASPEKYIYAPRQMAALSLQCSERGRRADEAEREVDERYRAAWMEKHVGGQFDGVISGVTSFGLFVELTQSKVNGLVHVTQLPQDYYQFDPIRKTMTGERRGREFRLGDPVRVLVLKASMEERKIDFRLAEEGAPAEAPLPPREKPAKRKKKPY
The following text describes a protein:
Function:
RNA-binding RNA annealing protein. May have a role in pre-mRNA metabolism. Component the TREX complex, which operates in coupling transcription elongation to mRNA export.
Subcellular Localization:
Nucleus.
Sequence:
MSANLDKSLDEIIGSNKAGSNRARVGGTRGNGPRRVGKQVGSQRRSLPNRRGPIRKNTRAPPNAVARVAKLLDTTREVKVNVEGLPRDIKQDAVREFFASQVGGVQRVLLSYNERGQSTGMANITFKNGELARRAVERFNGSPIDGGRSRLRLNLIVDPNQRPVKSLADRIKAMPQKGGNAPRPVKRGPNRKAAMAKSQNKPKREKPAKKSLEDLDKEMADYFEKK
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MAENGEEKLIAVARHIAKTLGHTDTMTDDILQIFSSFDNRFREKLTDDQPLERSLKSLHRQISRHLSAQHPIWSDSADSAAFLDSVDQLLAIIHEWNPMANDKSVSASLDKAEDLLQQAMFRLQDEFTTLMQRASESVDLTRHQNGGDNLGGYYESEEEEEEVDDDDDDDSGEIPIAHPVTDYGILIEALPAGIISDLHEIAKRMVAAGYDKECSHAYSVSRREFLEESLSRLGLQKLSMDQVQKMQWNELEDEIEKWVKAVNVALRILFPSERRLCDRVFFGFNSVSDLSFMEVSRGSTIQLLNFADAVAISSRAPERLFKVLDVYEALRDLMPEFEFMFSDQYCVLLRNEALTIWRRLGEAIRGIFMELENLIRRDPAKTPVPGGGLHPITRYVMNYIRAACRSRITLEQVFEEIIVPSASAVDYREGDDRALSSSSLAVQMAWIMELLESNLETKSKIYKDSALLAVFMMNNERYIVQKVKDSELGLLLGDDWVRKHAAKVKQYHVNYHRSSWSKVSGVLKIDNNAMSSPTGASRSLKEKLKLFNSYFEEICKTQSTWIIFDEQLKEELRISVAGALSPAYRNFIGRLQSNNDSSRHTERHIKFSVEDLEARISELFQGSSGSGGGRK
The following text describes a protein:
Function:
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.
Subcellular Localization:
Cytoplasm.
Domain:
Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs; The N-terminal zinc finger binds to poly(A) RNA; The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.
Sequence:
MESSPNRTARTPTSAALHQSKNRQCRNVLIHGHCRFEGKGCQFLHSTSTAVAATTIKDSKHKPGSAAIPILSRPMSSTGSSADTSITTKSPKINVDSPVFTPSRMPATTYTDHPSTSIQPSLYSSQNDYKLVAEDSEFEPFIQQPVMHFTPDHAYQYTDHEQFQHQQYEYNYYEQGNQYSDIQMMQVGMESMGLGSQQRMHDQYQDKASLETYFMHQHDGSPYLPLHYHHYNTPLPNVSHIPPHLKSSHNFFIDDQLREMLLKRNEAVQQVVDPSDWSNLPQSVDTYHTLFPLDESNAPSKIFGYPTSVYKAIRSTDGKPYVLRRIEGFRMLNEAAMMCIDNWQRVRHANIVSVIEAFTTKAFGDSSLVLVYNYHPLAMTLTSKYFSRHDTHLVRGMDERELWSFICQITSALKTIHMHTLAARAIDPSKVIVTGKNRFSLNCCGVMDMLTFEANSSLAQLQQEDLRNFGKLIVSLAVGSLPALQNIQKCLDHIRKHFSPDLTTVVMYLLGNTPAIKSIDGILQLIASRLLDEMDSAFRYNDRLEDDLSRELENARLVRLMSKLGFINERPEYDLDPTWAETGDVYLLKLFRDYIFHQVDQNGAPLLDLGHVIQTLNKLDVGVDEKIMLTSRDEKSCLVASYRDLKQCIDTTFREMIARRGWQK
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes to the barrier septum.
Sequence:
MEEKENVNLVEKSNYVALENTREIDVFDEFLNAIGNENTITPVYADSSLTHLRKKSYTKVVHDCTYALVINPYDKKVIWRRGLAYLRLGHPHLANRDWEHSLELDPNNTYIQKSLHRLKEVYYIYRECAETWQLRHLRVASSQQLPVGLRKQYPNIIRGKIWWKKVHDNCQLCGQQCELKKENLSAMRSMLYMANTYAKDDTENHSPSAQIGIESSEDELENKITKGEHSLLVPEELYRSNYPCPQNIDQFLYMIKVLSAPCLYIETFSFPISTINQLFKAHGMSVEQLNLFLKSIHYIGLCSRFCKQWSDKARSLMQALSGLPWFSFVVQHCLHITAAQILLHIPDIQEEEFRNWHVSKKPINNTDLSSEFEIAEIPINCYT
The following text describes a protein:
Function:
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Membrane raft.
Sequence:
MYWTDWGEVPKIERAGMDGSSRFVIINTEIYWPNGLTLDYEERKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDTLYWTDWNTHSILACNKYTGEGLREIHSNIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLESGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYVYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMAGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATSVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQGFTVVVSSVPNQNLEIQPYDLSIDIYSRYIYWTCEATNVIDVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPVALALDSKLSRLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGDIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDCYFEPTTILQAVQLPALCTAHYTLQH
The following text describes a protein:
Function:
Has ATPase and non-specific DNA-binding activities.
Sequence:
MMSGQSISGLQELNGIGERVACRLVEHFGSEEAALQAILEGDIASLSEVNGVSHTFALSLARDFRARVEGCAISDFLKTKEALDLYSRLLELIKTFAHTAHARDKLDLFYPFPASRMDLIQERRAFVGEYLELGDVLSADKEFLDLLSSVKKLRPVPGSLRVRDRVILSGDRKTLDEAKERFQAFLPVQAVESFSEFVDLARGYSNVIIFDDTYLAFDLPEGLEPEFFQDPSKAEFWQILPEVELAFFARNLDCILACLDITSTLRVLGFDFFEELSDEELETLKTALLKVGDDGKPVEGFDPELDRLEAALQNLDPVLTSVLNEANQRMNRTLEASSLTLSGQELIKLVSGGMEIKDLLAKELHRVYTGEIEAVKEELAEKLDFQKQEKLLLDSLFSDEIAYPLRAEQAQLQLLRQKLNMSFEKVRLARKRELAKVLSSFRRPVERLVREVLDFDLGFSIACFASRFRLKMPEPISEAGIGFEEGENLFLKARYGKIDPVSYSVGKTRFSPEGFENRVVLLSGVNSGGKTSLLELLAQCVVLGYMGFPVPAKELELGSVEEFYYFGKSKGTLDAGAFETTLKQFSVLSEASGKLVLADELESITEPGASARIIAGILEYLTRSEESLGVFVSHLSELILENTGTDIRVDGIEAEGLDSRLELIVNRNPIYNRVARSTPELIVERLLRKTTGKEQEFYAHLKNKFKN
The following text describes a protein:
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that binds and stabilizes U6 snRNA, probably by adding a methylphosphate cap at its 5'-end. Required for U6 stability, but not stability of 7SK snRNAs, other miRNAs or tRNAs. U6 stabilization is required for efficient pre-mRNA splicing. Essential for organismal and germline development.
Subcellular Localization:
Nucleus.
Sequence:
MDLENNNNTPLTGKQAEKCAKKRKCVITLDEKQVESKRLKKEESNVEATSRPPAQSPKKRLHLNGKPMQNKDLNFKYGNYKHYYGKRILNKDFHDIRLDVLGTQPDLFRNKQLLDIGCNSGHLSIQIARKFEVKSLVGLDIDRGLINDAQKTVSHLKRHATPGQGIPHIQFVHGNYVLEDDVLLEIERPQFDVILCLSVTKWIHLNFCDSGLKQAFRRMYLQLRPGGKLILEPQSFDGYKRRKKLSEQIRDNYNAIKFRPDHFTEYLLSPEVGFAEMKLMGIPEHCKVGFKRPIQIFTKS
The following text describes a protein:
Function:
May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MNPAISVALLLSVLQVSRGQKVTSLTACLVNQNLRLDCRHENNTKDNSIQHEFSLTREKRKHVLSGTLGIPEHTYRSRVTLSNQPYIKVLTLANFTTKDEGDYFCELRVSGANPMSSNKSISVYRDKLVKCGGISLLVQNTSWMLLLLLSLSLLQALDFISL
The following text describes a protein:
Function:
Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is unknown.
Sequence:
MMVTVVSNYCQLSQTQLSQTFAEKFTVTEELLQSLKKTALSGDEESIELLHNIALGYDKFGKEAEDILYHIVRTPTNETLSIIRLIKNACLKLYNLAHIATNSPLKSHDSDDLLFKKLFSPSKLMTIIGDEIPLISEKQSLSKVLLNDENNELSDGTNFWDKNRQLTTDEIACYLQKIAANAKNTQVNYPTGLYVPYSTRTHLEDALNENIKSDPSWPNEVQLFPINTGGHWILVSLQKIVNKKNNKLQIKCVIFNSLRALGYDKENSLKRVINSFNSELMGEMSNNNIKVHLNEPEIIFLHADLQQYLSQSCGAFVCMAAQEVIEQRESNSDSAPYTLLKNHADRFKKYSAEEQYEIDFQHRLANRNCYLDKYGDANINHYYRNLEIKHSQPKNRASGKRVS
The following text describes a protein:
Function:
Global regulator with both positive and negative effects that controls the expression of several virulence factors and the biofilm formation process in a cell density-dependent manner.
Subcellular Localization:
Cytoplasm.
Sequence:
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL