lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-rhamnose and L-arabinose. Binds D-arabinose with the highest affinity, followed by L-fucose, and then by L-galactose.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
Contains an outward-open, amphipathic cavity. Contains only two acidic residues along the transport path, Asp-46 and Glu-135, which can undergo cycles of protonation and deprotonation. Asp-46 and Glu-135 have an essential role, coupling proton translocation and substrate recognition. Sugar binding probably induces a conformational change in which the outward-facing cavity closes, thereby bringing Trp-38 and Trp-278 into close proximity around the bound sugar to form an occluded intermediate.
Sequence:
MGNTSIQTQSYRAVDKDAGQSRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSNVPHQSQDVLDKMSPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGSFSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVEEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLISAFAGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSDAAGNIPTAELIPALCFAVIFIFARFRSQTATN
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the 7SL RNA, srp72 binds to this complex subsequently (By similarity). The SRP complex possibly participates in the elongation arrest function (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MDPHVKLSTSLVIIAFRYLPNNFNDSRLGCDNLSTVGLCLKNGTGEVLFSGLIKQMANFYIFPLLLEARSDHFYEGNEYIKYLSHRIHGLRKSLHITQRGGKPKSSVDKRYAEILLFNADRAFQQFVFLRSSQRRHALRRLKRADQFGKELVSFTNAFDCNDHIFYLEAIAFAKYIEGTLNYEKRDWEGSLSAFSISRLSFLVLQNKIDTLAEHEKSVLGELQNQIDSNLRYVAQRTGLQNQTKSLDILMLSSIPKDEEVIQHVNSVDSEILQMTGDEQDSLQTITVIEWRDQRVKIEHPDVVLALYAIHDVKNSPGTIDSKRDRLLAAWARAEEITKSVLDNTGLEDEQKFQTLSICYTYLAYNVVLLRIQRDLAVENDSELVASQAQLRSRQSLYDSIIKNIEIAKELPGIARDTGMTAQLEAQISLAKSKRCQAIADAYQAQDKLASLAMCVRAASYLQQVNDILRNFEEKPHLIAFDIIPELKKDEKELKKKILLLQSLASMGNINQPPKNLSLVETLDSYQTLAELEPSWNLTDADIRAIPAKPLFFDLAITYLGQQTSFDKKKAQPEKPVTSVSKEPKQKNKGFFSSLLGR
The following text describes a protein:
Function:
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MTQAEEVRPSSIFDIRSGTIQSGDTVIVYQSRDNLTAIVVTPGQQLNTRYGEFPHSDMIDIPFGSKCPSRKGNGFTYLLRPTPELWTLALPHRTQILYHPDISFVTSQLNIKPGSYVIEAGTGSGSFSHSIARTIGPGGKLFSFEFHEERHTKAAAEFQAHGLLSSVGGPIQLAHRNVIRDGFGDLDVKVDSVFLDLPAPWDALEESKRVMNRSQLSRICCFSPCIEQVQKTCQTLESLGFSDIIMFETLVRTHEPVSLTMPKVDDAVRRIKEVEMKKQARRERQISESKQRRQVTQKPSSPKPASDERNTKRGLDGADATEEPELKKPREEKCNGSPVCAKSEEMDTIMVEDIKPVVTETDQALPEVQQTVMLETSKPAGMTRGHTSFLTFAVLLPLPKP
The following text describes a protein:
Function:
A transposase that is part of insertion sequence (IS) element ISDra2, it is necessary and sufficient for both transposon excision and insertion of ISDra2. This protein alone can be provided in trans and allows transposition of an empty IS element (tnpA or tnpA-tnpB replaced by a selectable marker). ISDra2 binds subterminal imperfect palindromes at the left (LE) and right (RE) ends of the element and cleaves only the 'top strand' which is circularized and subsequently reinserted into the DNA target. This is called a 'peel and paste' mechanism and increases the copy number of the IS (Probable). Transposition is linked to DNA replication in the absence of irradiation, with maximal activity when the 'top strand' is on the replication lagging strand, and occurs preferentially on the lagging strand. The IS element inserts 3' of the target sequence 5'-TTGAT-3'; target duplication has not been observed.
Miscellaneous:
MISCELLANEOUS: Belongs to the IS200/IS605 insertion sequence (IS) element family, formerly called IS8301. This element is subject to strain polymorphism; in the ATCC 13939 / R1 strain genome sequenced by White there are 7 complete and 1 incomplete IS200/IS605 elements. Another R1 strain has only 1 copy of this element. Another group found 2 copies of this element in untreated R1 strains.
Domain:
The helix containing the catalytic Tyr-132 (residues 127-133) is highly mobile. Recognition of the 5-base sequence immediately preceding the cleavage site is mediated by base-pairing to an imperfect palindrome, by sandwiching the fifth nucleotide between Tyr-30 and Trp-107 and hydrogen bonding to His-32, and by main chain atoms of Leu-106 and Trp-107.
Sequence:
MTYVILPLEMKKGRGYVYQLEYHLIWCVKYRHQVLVGEVADGLKDILRDIAAQNGLEVITMEVMPDHVHLLLSATPQQAIPDFVKALKGASARRMFVAYPQLKEKLWGGNLWNPSYCILTVSENTRAQIQKYIESQHDKE
The following text describes a protein:
Function:
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.
Sequence:
MDCYTANWNPLGDSAFYRKYELYSMDWDLKEELKDCLVAAAPYGGPIALLRNCWRKEKAASVRPVLEMYSASGMPLASLLWKSGPVVALGWSAEEELLCVQEDGAVLVYGLHGDFRRHFSMGNEVLQNRVLDARIFHTEFGSGVAILTGAYRFTLSANVGDLKLRRMPEVPGLQSAPSCWTTLCHERVAHILLAVGPDLYLLDHATCSAVTPAGLAPGVSSFLQMAVSFTYRYLALFTDTGYIWMGTASLKEKLCEFNCNIRAPPKQMVWFVLDEDSYLVPELDGVRIFSRSTHEFLHEVPVASEEIFKIASMAPGALLLEAQKEYEKESQKADEYLREIQELGQLIQAVQQCIEAAGHEHQPDMQKRLLRAASFGKCFLDRFPPDSFVHMCQDLRVLNAIRDYHIGIPLTYTQYKQLTIQVLLDRLVLRRLYPLAIQICEYLRLPEVQGVSRILAHWACYKVQQKDVSDEDVARAINQKLGDTPGVSYSDIAARAYGCGRAELAIKLLEYEPRSGEQVPLLLKMKRSKLALSKAIESGDTDLVFTVLLHLKNELNRGDFFMTLRNQPMALSLYRQFCKHQELDTLKDLYNQDDNHQELGSFHIRASYAAEERIEGRVAALQTAADAFYKAKNEFAAKATEDQMRLLRLQRRLEDELGGRFLDLSLHDTVTTLILGGHNKRAEQLARDFRIPDKRLWWLKLSALADLEEWEELEKFSKSKKSPIGYLPFVEICMKQHNKHEAKKYASRVGPEQKVKALLLVGDVAQAADVAIEHRNETELSLVLSHCTGTTDGAIADKIQRARAQAQKK
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
Subcellular Localization:
Nucleus.
Sequence:
MEELFKYIRKQPEDFVINLISDQDACRTYIRLLPPLSQQILFRLLYIERGFPRSEVEKWSPKSKSNDLINAIKKLIKAHLVYIVTDTISENSYNSSIIINKRVREVLLGTYVEDKKAFVRQKNPFAPDDQPDENFVPFDELDQSKFPTIDEKILDDFSNYQLESILSFMLKLRDNIDNEAKKILSDAKLMEFGGNLCPKGHRFLLLSPKEQIWRIVKCYLKFTKDLHSSLRFLLKIGSMELSKGYPITSLTPTQKELLSPFKTIGLVYIDGDYFYPTKSILNFFGKSNIFQTEGWMLIDTNFKITAFPKSPLHTALLKKFANVTYEFPGFASAFISPNSFREALNQGTTLDDIIGFLKSNLSHKIGSGQIPSAVMKQFYVWRDQRERLTVTHECIMRQYTNPNDANLAAQCAKQLAGYVYGPAEKKESHYWIVITLSSIEQSYKPYLDMIQNNSENGGYI
The following text describes a protein:
Function:
Transcription factor involved in segmentation. May function primarily as a segment polarity gene. Different levels of slp activity seem to be required in different segments.
Subcellular Localization:
Nucleus.
Sequence:
MVKIEEGLPSSEISAHSLHFQHHHHPLPPTTHHSALQSPHPVGLNLTNLMKMARTPHLKSSFSINSILPETVEHHDEDEEEDVEKKSPAKFPPNHNNNNLNTTNWGSPEDHEAESDPESDLDVTSMSPAPVANPNESDPDEVDEEFVEEDIECDGETTDGDAENKSNDGKPVKDKKGNEKPPYSYNALIMMAIRQSSEKRLTLNGIYEYIMTNHPYYRDNKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSAEDVFIGGSTGKLRRRTTAASRSRLAAFKRSLIGPMFPGLAAYPQFGQFLTYPPTAPSLLASMYQRYNPFAPKGGPGHPGLPPGLPGLPGPPGPQGPPGPPPPPFVAPPTSSELYQRLQYQQLLHQHAAAAALAAHQRQLSVAAASAASQPPPTHHHPHLAVGQAPLSPGGDSPGPSPQPLHKPVTVVSRNS
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (Probable). This system may be involved in sucrose transport. The EIIB domain is mainly phosphorylated by the EIIA domains of GamP and PtsA/YpqE; Negatively regulates SacY activity by catalyzing its phosphorylation on 'His-99'.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The PTS EIIB type-2 domain may serve a regulatory function, through its phosphorylation activity; The PTS EIIB type-1 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-1 domain; The EIIC domain type-1 forms the PTS system translocation channel and contains the specific substrate-binding site.
Sequence:
MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAIENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAAAFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLPILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQGSMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQIMTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIWSMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAAIGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATLFLGFKEETE
The following text describes a protein:
Function:
Catalyzes the hydroxylation of n-alkanes in the presence of a NADH-rubredoxin reductase and rubredoxin. It preferably hydroxylases C8-C16 hydrocarbons.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MFENTNPDVMLKMKKYGYLAFWAIMVPLVPFSAFVGVESGTQDYWAWFMYAFIFGIIPVLDYLVGKDPTNPSEDVQVPTMSEEVFYRVSAIAMGFVWIAVLFYAGHIFMNNGYGLLGKIGWIVSIGTVGGIIAINLGHELIHKDPKVENWMGGLLLSSVTYAGFKVEHVRGHHVHVSTPDDASSSRYNQSLYNFLPKAFVHNFINAWSLEKKYLERKGKKNISVHNELIWWYSISALFAATFGLLWGWQGVVFFLGQSFFAALALEIINYIEHYGLHRRVNDKGRFERVTPAHSWNSNFLLTNLALFQLQRHSDHHAYAKRRYQVLRHYEESPQLPAGYATMYVLALIPPLWRKVMNPRVEAYYEGELDQLFRDGKRVNNIA
The following text describes a protein:
Function:
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.
Subcellular Localization:
Nucleus.
Sequence:
MEVPNNFEFPFQPYPIQHAFMRNLFEVIENKKFGIFESPTGTGKSLSILCGAIRWLKDHNMYERENLKLQIEELELKKRKVSGNSSDWLSAQAQEIDLNRQINELKIRQNKIDEYDKKIESLRKKKKEKKSVKTKLVVKEVNENEDDEIVLDTDVQSDDEKEESDDESSTFKPTKIFICSRTHSQLSQFIGEILKSPFGKNIRVASLASRQNYCINPNVNKLKNNSLINEKCLDMQKQSKSQKDADGKTIKKPRGTTTKCPYYKQSTIEDLKDLTLTEVQDVEDLVKSGKELNACPYYSSRLAAEDAEVVLVPYNTILHKATREANGIDLKDNVIIIDEAHNLLEAMGQMYSSELTYSQIDQGLLQVKCYKQRFNTRFSAPNLLLINQLIFVITKLQQLLDQNSEEKTDVFTIENFVLTAKIDNFNMFRLVKFCKDGRIAQKVRSYALKYPFDKSIIEKPAKKGVKDFLSSITNKNETVEQNIEKPAAFALTNPLLAIISFLETLTYSYKDGRIFVHTNQDKSKIKLQFLLLNPTQNFEDIVKLARSVIVCGGTMKPNEEFRNRLFISSGVSPERIFEFSCGHIIPPENILPVIMTEGANKEKLLFNFERRMSMGGCIKRILVEVCKVVKGGIVVFFPSYNYENWVWQQIKDVSFGRLVFREPQDSGSVDSVLKSYSDAVHKSNSGALLLSVVGGKLSEGLNFSDDLGRCVIVVGLPYANITAPDLKEKMSHLDKIEGSGAGKRFYESLCMKAVNQSIGRAVRHKNDYATILLLDERYNRTATKEALPDWIKKSLKVCNFQDTFTNMRKFFEDRRKIL
The following text describes a protein:
Function:
Required for normal embryo development. Necessary to acquire heat stress (HS) memory, by modulating nucleosome occupancy and regulating heat-induced gene expression. Associates globally with the nucleosome-poor regions flanking the transcription units of expressed genes. Binds to the promoter regions, primarily to the proximal promoter just upstream of the transcriptional start sites (TSS) and somewhat more weakly to the region downstream of the transcription termination site (TTS), of actively expressed genes (e.g. HSA32, HSP18.2 and HSP22.0) in a heat-dependent fashion.
Subcellular Localization:
Nucleus.
Sequence:
MTQSPVQPPPPLPAQPHSAAGGVIRGDVQVRCAGCRVILRVKTGVVEFSCPTCQLPQMLPPELLSRARPQFPQSPQQPPQPIQTLPPPIQQQLKPLNLPRPPVPAHGIDPTKMQLPCANCQAILNVPHGLTRFSCPQCHVELAVDVSKLNRSLTASQSHSNPPTPAAPTVPPPPPPEEVNEEAIEVEREEDEGGTAGETFMDYRPPKLSIGPPHPDPIVETSSLSAVQPPEPTYDLKIKEELERSKALSCLQIETLVYACQRHLQHLADGTRAGFFVGDGAGVGKGRTIAGLIWENWKHGRRKALWISIGSDLKYDARRDLDDVGATCVGVNPLNKLPYSKLDSKNVGIKEGVVFLTYNSLIASSEKGRSRLQQLVQWCGPEFDGLLIFDECHKAKNLVPEAGSQPTRIGQAVVDIQDKIPQARVIYCSATGASEPRNMGYMVRLGLWGAGTSFSDFNKFLGALDKGGTGALELVAMDMKARGMYVCRTLSYKGAEFEIVEARLEAGMEAMYNKSAEFWAELRIELLSASAFLPNEKPNSSQLWRLYWSSHQRFFRHLCMSAKVPVTVRLAKKALSTNKCVVIGLQSTGEARTEEAVNKYGLELDDFVSGPRELLLKFVEENYPLPEQPEPLSEDDSVKELQRKRHSASPGVSIRGRVRKMAKWKPDSDNESDLESEADSADDSNDSDDEFQICQICSGEDERKKLLHCSECDKLFHPDCVVPPVIDLPSEAWICFSCKEKTEEYIQARRLYIAELQKRYEAALERKSKIIEIIRSLNLPNNPLDDIVDQLGGPEKVAEMTGRRGMLVRASNGKGVTYQARNTKDITMEMVNMHEKQLFMDGKKLVAIISEAGSAGVSLQADRRAVNQKRRVHLTLELPWSADRAIQQFGRTHRSNQTSAPEYRLLFTNLGGERRFASIVAKRLETLGALTQGDRRAGPSGPSLSAYNYDSNFGKKSLMVMYRGIMEQEKLPVLPPGCSIDEPETVKEFLTKARAALVAVGIVRDSVLANGKDVGRFSGRIIDSDMHDVGRFLNRLLGLPPDIQNRLFELFTSILDVLVHNARIEGSFDSGIVDMKANSVELLSTPKTVHVDQMSGASTMLFTFTLDRGVTWESASSMLEGKRRDGLGSANDGFFESKREWLGRRHFILAFESAASGLFKIVRPAVGESIREMSLSELKTKYRKLSSLEKARTGWEDEYEVSSKQCMHGPKCKLGEYCTVGRRIQEVNVVGGLILPIWGTIEKALSKQARHSHKRIRVIRIETTTDNQRIVGLSIPNAAVETVLQDLAWVQEIDD
The following text describes a protein:
Function:
Catalytic subunit of the NovJ(2)K(2) heterotetramer that catalyzes the NADPH-dependent reduction of the tyrosyl moiety of L-beta-OH-Tyr-S-NovH intermediate to yield the tethered beta-ketotyrosyl-S-NovH in the novobiocin biosynthesis pathway. Novobiocin is an aminocoumarin family antibiotic that targets bacterial DNA gyrases.
Sequence:
MTSPADATTEVAVSQESVAMVTGAGRGIGAATAERLAAEGMAVIVVDRTEQDTRATVAAIRTAGGRARGIGCDVAVAQAVTAAVATAVEEFGRIDVLVNCAGINRDRLLLTMGDQEWDTVLDVNLGGTMRCSFAVGRHMRRQGHGRIINFSSVAARGNAGQTNYATAKGAIAGFTRTLAAELGPHGVTVNAIAPGFVATPMVDELAERLGGDRDSVMSEAAKSSAVGRIGTPEEIAATVVFVARPESGYLTGETVHVDGGRP
The following text describes a protein:
Function:
Probable receptor tyrosine kinase which is required for determination of anterior and posterior terminal structures in the embryo. During postembryonic development, involved in the initiation of metamorphosis probably by inducing the production of ecdysone in response to prothoracicotropic hormone Ptth. Binding to Ptth stimulates activation of canonical MAPK signaling leading to ERK phosphorylation (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLIFYAKYAFIFWFFVGSNQGEMLLMDKISHDKTLLNVTACTQNCLEKGQMDFRSCLKDCRINGTFPGALRKVQENYQMNMICRTESEIVFQIDWVQHSRGTEPAPNATYIIRVDAVKDDNKETALYLSDDNFLILPGLESNSTHNITALAMHGDGSYSLIAKDQTFATLIRGYQPSKMGAVNLLRFVPQPDDLHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPLEVQFRDRKKLYRHTVDNLEFDKQYHVGVRTVNIMNRLESDLQWLPIAVPSCLDWYPYNYTLCPPHKPENLTVTQKQYLPNILALNITWARPRYLPDNYTLHIFDLFKGGTELNYTLDQNRSHFYVPKITVLGSHFEVHLVAQSAGGKNVSGLTLDKVHRGVLLSEGNMVKLVLFIIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEFHLSLMDSSGLLVTLSANESLEVMDELEVEPHSVLLQDVLGEGAFGLVRRGVYKKRQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILATNDVPERLKQLQAATESKLKSCDGLNSKVEQVPCEEELYLEPLN
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MGKPLGPTGEFFRRRDEWRKHPMLTNQFRQATPGLGIALVAFGIYVVGEMAYNKIYAPPPPSHSSSHPH
The following text describes a protein:
Function:
Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). Involved in oxidative stress tolerance by mediating regulation of mitochondrial retrograde signaling during mitochondrial dysfunction. Interacts directly with the mitochondrial dysfunction DNA consensus motif 5'-CTTGNNNNNCA[AC]G-3', a cis-regulatory elements of several mitochondrial retrograde regulation-induced genes, and triggers increased oxidative stress tolerance.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus. Note=Localized primarily in endoplasmic reticulum membrane as dormant form and, upon oxidative stress, is processed into a transcriptionally active and nuclear form after a proteolytic cleavage through regulated intramembrane proteolysis (RIP).
Domain:
The NAC domain includes a DNA binding domain and a dimerization domain.
Sequence:
MDLSVENGGLAPGFRFHPTDEELVVYYLKRKIRRKKLRVEAIGETDVYKFDPEELPEKALYKTRDRQWFFFSLRDRKHGSRSSRATERGYWKATGKDRVIHCDSRPVGEKKTLVFHRGRAPNGERTNWVMHEYTLHKEELKRCGGEDVKDAYVLYKIYKKSGSGPKNGEQYGAPFIEEEWAEDDDDDVDEPANQLVVSASVDNSLWGKGLNQSELDDNDIEELMSQVRDQSGPTLQQNGVSGLNSHVDTYNLENLEEDMYLEINDLMEPEPEPTSVEVMENNWNEDGSGLLNDDDFVGADSYFLDLGVTNPQLDFVSGDLKNGFAQSLQVNTSLMTYQANNNQFQQQSGKNQASNWPLRNSYTRQINNGSSWVQELNNDGLTVTRFGEAPGTGDSSEFLNPVPSGISTTNEDDPSKDESSKFASSVWTFLESIPAKPAYASENPFVKLNLVRMSTSGGRFRFTSKSTGNNVVVMDSDSAVKRNKSGGNNDKKKKKNKGFFCLSIIGALCALFWVIIGTMGGSGRPLLW
The following text describes a protein:
Function:
Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.
Sequence:
MDQDPVESSPERAISSEPCSTHPLPFDDNEQHSARKRQKTSRSGSRSRSVDTAKASNIPPDSMSSHKDDSDILHDSFPPSTPTRPGTAQSQTGPTSSRVTINLRTPQPPLESIYFSSPSPNTPSKMTHIVDDEGARISIESESDVLSTVPASVIETPSSSPSVMEGSPEVELVPISSDDPERSPTLGIIDEEEVFPDPLNHFPAQRRGENMLHALRKVLHILQFESNHIGRSLETHYNWKWDEDTAELQTYFEDGGGSMLALTKFVEGQSRFLPNCPRLFENFSEPSKLMDRMSLLAAVAKRQSGPEIYDDASRKLAHGYDYFNVMSSALDSIIEKNATFLTPEAANTHLSCLTQILWNSATWNPRIAKSQMEIHRKICPDLPIPMLSKAMALEWKFFVLQKLITSTQMQLRVVGVTTMCADLLNLHSTYRAKEAPPSGGLVLLHFAKLVLQHKLIDYIVGIGSHPEIINESGNIVGFLVVTKTYEDEQTDLIWQTVITSQDPRVVEAILRMMKKVLNLLEYPACLYICQKVAALPIQAFTVAMRDFCEHLFRELSSKVGRSDLDASPYDICVRLIRESSIISDEYPNGYPEIQNFAASHLRELLVHGPGQEARTDIYLSCIKDISDKTATAPGSICVVSALLHQSLMPDLHTLTAQHGLTRLMVDELESNIAGNRSLAYDSPANIARREILLQIILMDPDTINAELGTRLWNLLVGSQSNDTADRLAGWQILNKAFQKAKFSNRYLTICFQSYLPHLEPNHFLDGTLLFVKSGVDFWLEEKEKESQEDENVKLDLSFDFLAMEQLWRIIESAPQGKVYEQAIQELVGVYVGPFIRSLPHFKTRELHLAFLTRCLDKLADAAGRLKTSSTDGVRSDDEDMVVVLPEFHIQEQELLFIRSLAALQTFLATYSCHAHFATPKLRSAVSIPSDTVEGTSLTIMYQAFGETTSCIKKLTIGAKDTAATLVAKLQKETDFTSCRVFYSGKEFMHDDAELCKSVESLNLNGLVLVKRRDETNPQLPSSNGPLQSEITRNFDQIWSYLGMQENLAEKIYSFLIQFPVYDRVLQDLSNSAVPYTEIFPLGQPYKALYGLYGLKQYIPSQSSKGFIDAASFDRAMTLLVAAISDPKFLESCAPQTIRETLAMHFISSLASLLKDPALPASSTVGINDKLLERLLDLLYAAKSVAGGEASVHLIWTSVEALLEVAIQNSALWSTFIRHLNGSDLLQDLLLEDLRPFVRKAISKHITSKSTFNPNPAHVSPSEVAITLWPIVAKLIPEAVKRPGQCEETFQLALTIFKRLLETEVDVDLITVAREWGELLIHHDNCEDVGVPEAVDMVTQGLANLLHHAVMSMKHPEQKLSCRGLGLRIFKRRLFPTISNEDDIGNDGLIAQKIPVINSKTRHTMGETVLALVKDDITQYKELLQLLSEVAPYEHRAIDPYLFDMQIVYERSKAVRSPTGYVGLKNLSNTCYLNSLVTQLFMNLSFREFILHSPITVPGSQKLLIETQQLFSFMQNSMQRFIDPTNFAASITTFEETEIDVTVQMDVDEFYNLLFDRFERENLTDDDKRKVRSFYGGKLVQHASNRKNALISRGD
The following text describes a protein:
Function:
Catalyzes the O-glycosylation of multiple protein targets. Is responsible for general protein glycosylation within A.baylyi ADP1. Does not act as an O-antigen ligase.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAGSPRVYNSQHCGFSVAVMRFLLLLLTAVLISLAWLSPDHSYPWLTFASEMLSFAAFLSLLALFLNRPLELPRVQLLALPVVFIPMIQWGFGLVVDFSSALLSSAYLLGFWLTMLLGYNLSRSSADRERMFTLSSYLLFAVALLTSLIACIQWLNLESHVPGVMNLYSHRPYANFAQPNNMSTFLILGLLGCLYLAEKQKLKQYYIWPVAALIVFAITLSQSRTAWVFGLFFIIYWTYKSWRYPTHLKRYAVLLWAIGFFAVGLLFPRFTRLIQKLKEGNVVQTSSVVERASAGHERLGIWQQMLDAIHQKPWTGYGWNQTSIAELSSMSSNTIHVWFTSAHNVVLDLLVWNGWLLGGLITICILIWICWLNVHAKTTESIIACLMVSAVWIHTLLEYPLQYAYFLLPVGFLMGLIQAQTPDQTARSVPVSVIRSIWVIGIMLLALIWRDYNLYKVNSLRILKNQPANIEIWGSSKILVLTEFDQRLYWLKLSPVAPLTSTELDQIEKMVQNKATPYNLQKYAQLLLANHQFEKAQQQIAYLNRLHKKDYTLQDLQQANASAVESSK
The following text describes a protein:
Function:
Multidrug efflux pump.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYKTKCLREKLVLFLKIFFPILIYQFANYSASFVDTAMTGQYNTMDLAGVSMATSIWNPFFTFLTGIVSALVPIIGHHLGRGKKEEVASDFYQFIYLALGLSVVLLGMVLFLAPTILNHIGLEAAVAAVAVRYLWFLSIGIIPLLLFSVIRSLLDSLGLTKLSMYLMLLLLPLNSGFNYLLIYGAFGVPELGGAGAGLGTSLAYWVLLGISVLVLFKQEKLKALHLEKRILLNMDKIKEGVRLGLPIGGTVFAEVAVFSVVGLIMAKFSSLIIASHQSAMNFSSLMYAFPMSISSAMAIVVSYEVGAKRFDDAKTYIGLGRWTALIFAAFTLTFLYIFRGNVASLYGNDPKFIDLTARFLTYSLFFQLADTFAAPLQGILRGYKDTVIPFYLGLLGYWGVAIPVATLFDSLTDFGAYSYWIGLIISLIVSGALYRWRLTVIMKRFESLAKSKR
The following text describes a protein:
Function:
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MLQWRRRHCCFAKMTWSPKRSLLRTPLTGVLSLVFLFAMFLFFNHHDWLPGRPGFKENPVTYTFRGFRSTKSETNHSSLRTIWKEVAPQTLRPHTASNSSNTELSPQGVTGLQNTLSANGSIYNEKGTGHPNSYHFKYIINEPEKCQEKSPFLILLIAAEPGQIEARRAIRQTWGNETLAPGIQIIRVFLLGISIKLNGYLQHAIQEESRQYHDIIQQEYLDTYYNLTIKTLMGMNWVATYCPHTPYVMKTDSDMFVNTEYLIHKLLKPDLPPRHNYFTGYLMRGYAPNRNKDSKWYMPPDLYPSERYPVFCSGTGYVFSGDLAEKIFKVSLGIRRLHLEDVYVGICLAKLRVDPVPPPNEFVFNHWRVSYSSCKYSHLITSHQFQPSELIKYWNHLQQNKHNACANAAKEKAGRYRHRKLH
The following text describes a protein:
Function:
Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response. Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection (By similarity). Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling (By similarity). In addition, activates PI3K signaling pathways independently of calcium flux (By similarity). Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKSDLRYFFLFCIQVEILAGEFNDSAASEMFIFHNGGVQILCKYPDTVRQFKMQLLKGDNVLCDLTKTKENEDTVSIRNLNVCKFQLSNNSVSFFLYNLDSSYASYYICKLSIFDPPPFQVDILSREYLNIYESELCCQLKFWLPIGCAAFVTVCVFGCVLMYWLTKKKYPTSVHDPNSEYMFMAAVNTAKKPAPTDVTRNLELPGTQA