lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable polyketide synthase.
Sequence:
MNDNDDDLVAIVGVGCRLPGNSNSPNEFWETIKNKKDGIIEMSERFSDNFFISNQFGLKRAGLISMNEWKSFDPIFFGISPSEALTIDPSQRLLLKCTWEAFEDASIDPLSIRGTSATVYVGTSTPEYQYSTVSNYEPIKNLFGATPHSLANRISYCFDLRGQSLSIDTGCSSSLNAAVLGYNSIKDGQCDISVVGGYNFLMDPFFTKGLCQLEMLSKSGKSCAFDSSADGYVRGEGCGVVVFKRLKAAIRDSNRIYCVIEGANSNVDGYYNKNTFYAPSIPSQVENIIKTFKSAKRSIKPKDVSFFECHGTSTLVGDPIETEALSRVFKENHSPDSPLLIGSIKPNIGHLEGGSGIASLIKCCLMFKFKKFAPNINFENPNPKIKFDEWNLKVNTQVLPFPNKNTTIMMNNFGVTGSNACLLLSQYNHSQNKDDLYADSGIKNKKEYLIPFSANSKKSLRNYQISIVNNINHYKNNSNLFDFIKCQINSRSNKLLQRSMGKAKNWDDIAKIDNYIDTSHSKVSNITVSKRQPQNIVFIFPGQGTQYIKMGSSLYQTNQTFKLWVDKIDSKLEKYFGFSIWKKINSFSESDKETMNEPIIAQPSISMIQVALFHIYIRWNINPSFIIGHSLGETSAQFCSGNIDLETFCSILYNRSVSQQKTVGLGRMLSINIGEKEFKEKYSYKYPSLEISCYNSPNSIVVSGIETVLFNLKSDLKNDNIFSILLSTRSSFHSSSQETIKEDILNCKFKTQLRPTIPVFSTVYKKIFGPTLAYDPKYCFENIRMPVLFAETIEAFYQHIETNSLSNEIVFIEISPHPTLLYYLKEMVPKDSNYFTDESIIILSSLNKKNNSNDQTEINNTISKLYCFGYNNLNFNQQFEQITINKHVDLPFYKWEDEKYFLEDHQHYLNRTQGPPIDLLGTENLSPIKSFTTYIDVKKPIFQYLKGHAVNGGFNFPGFGYVDNVINMYAENDLIIDGIEFKDPLIFKAGENTILHTNATQVLKNQLKVHFHYYNNKSDKWIETSNVNVYLVDHDYDNKELKMDIDQLKKECNHYSVTTDDLYNFIKSKTGVRYSENFIGVKECYYGDNKCLSFIPINLPNTNLGIPNSIINVTTLDSCLHGLLGLIKDPCQLFLDRLENFKYFSRNIPSIGEVDHVYSYGELNFIYNNSYYVTFKVLLPDGTILVEVDNIILTSSIEIKDSLNIEYEPNFYYEYYLESIESSVPTPSHFKDLINSLPTMDKNEIKYYEKYIINALLNNVNEKTNIDLDIVQKLSIQELENKYLNEKKNQKLFNFIFNLIKENIDSIEKNRDNVNQRVEDKSMSLNSIINASLQIILINLFPSGNHNLMIEFPESRYYSGWLNYFYENNTNINNLDKLVVEIIKKSIIKQANKKYVVRILEIGGGIGSLSEKVVNGLNTIIEANPNIETDIEYTYSHESPSHFVQVKQKLKHFNGNVLFKVLKLQDDSVENQNFKPNYYDFIIASNTLHLVKEIKPAINQIYRLLKPNGQLLFLEFSQQSLLANTVFGFFDEWWSFKDIGLRSENCLLTQGQWESILSNTKFTDTIMTTEDNSFSYLIQTRKEFQYNSNVKSSSEVIIFTFDRENRSSQSNEIIKQIYEKYSGAIIVGDLDELLSKLSNTSKVYFIKTIEELNLENFKTVTLEYIKINQHMIKNNLTTKIILVTIKSFEESNNYLNSSVNGTFRYFCEDQEQLVLYCFDLDCIDSCCIDLIDSLSNENNFIQTEFIVRKQKVYIEKMKRIKNSINKYTSKQKTPNICKDSFICKYNFKLQMVLDNKEELKPGQVEVDVKAAGLDYKDYLIYKKKKILNNKFNTFGSEFSGTVKRVGINVKNFKVGDHVYGLKTNTTQTSIIINSDQISQIPNNISLVEAASVPSIYINSYYCLFNIGDLNILDNESILIHSSTNDFGLALLNILKWKEFSSQLFVTVNSDEKRDYLIQQYGSFISGIFSVNNFEKEIKANLMKSNKEGIDLIFNSISNEFMDSNCRLLSCGGKIIDTNINEIDNKEQLNLNLNLNGNYIKLNSISPKTAIKILRSITQAFNEGHLKPIPINKYSNINIKNALLEINKKNTIGKVIVEFDTDILQPLLTEKNNHKIIESTYKITSVGKTILVTGQTGIALEIIKWIIKFSNNIENIIILSKSKMKWELKSLIQSVTNDTKKNHIKFHFNSVDVGNKTELYNSIQQLYNEHPTMDKVDSIFHYAFVQVVNGPLEISMKDLDLSHGAKSNGAINLHTLSLDFNWPIKNFVMASSTAAKFGSFNQCSYVSSLCVIDALSRYRKSIGLPSISINMGSILSVGIAAKSDTILSMLESQGIHHINVNQLLGSMDIVLHNQTDISSFVVYNVHFDNVQIKKYTYPIIDYYLNPIQNKTIKENDPTNSNNKQDEKDKIINKICEILSLEPSKLNTSNSLYEYGIDSLASTNLRNWFSKEYYVNIVTVDQIQNLTIVNLVNQIKNYINKKK
The following text describes a protein:
Function:
Transcription activator. Doesn't appear to bind to the consensus 5'-AACAAT-3' DNA binding site, but binds 5'-ATTGTT-3'. All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function. In addition, the sox17 proteins have distinct but overlapping roles in later gut development. Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly and indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-catenin-mediated signaling (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MSSPDCGYASDDQIQRSCSLPMMMGQYQWTEPRTVFQEGKPKRDEVSANSRSKAEARIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKSLNLATKRPFVEEAERLRVQHIQDYPDYKYRPRRKKQVKRMKREEECFFPSANIPGPEAMVNNVMVGQKYKMQYSVQNLQENQLPTAGYFEGHSPMGYFYKDYDVPNYYTSQNSSGYCSPPTQDEYQALSYGFGSSYMPYQQTTTTPVMAKQISVTQNIPQESPEHGMMASPQMYNGQMYLPECAKTHPVAQTEQHSPSHQSQQMVSQNYLQSQQDGHLETDIDKTEFDQYLMYEPKSDPELIYTIDQDSGPYSTNLLPSLISEANNVCYYDYCGV
The following text describes a protein:
Function:
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Sequence:
MHENRTSYPKRKTQMYQQLQELPKKYKVMAIIKMNKVRSTQILPLRKTLKDDVEFFSVKDKVAQKALENSDIPGMKDMIGEFKGQVMIMFTNMSPFKLNVLLAKNKIMMMARGGDIASVDVVVPAKNTGIAPGPMLTEFKEAGIPTKIDQGTIWIAKDSTPVLKGEAINEKLAAILGKLDIKPVEAGITLFTALEDGLKYAEEEMIIDVEKVRDEFAQAHQEAISLSIEAAYVTPENIEQILAKAAQSARSVSVESGYMTDETKEQILQKADAQARAVAGQAKDYTPA
The following text describes a protein:
Function:
Oxygenase that catalyzes the hydroxylation of a ribosomal protein.
Sequence:
MTALSSVDFCLPEHITPEIFLRDYWQKKPLVIRNGLPEIVGQFEPQDIIELAQNEDVTARLVKTFSDDDWKVFFSPLSEKDFQKLPEKWSVLVQNLEQWSPELGQLWNKFGFIPQWQRDDIMVSYAPKGGSVGKHYDEYDVFLVQGYGHRRWQVGKWCDASTEFKPNQSIRIFDDMGELVIDEVMNPGDILYIPARMAHYGVAEDDCLTFSFGLRYPNLSNLIDGISKGFCHQDPDLNLSEFDLPLRLSQSEQRTGKLADENIQAMKQLLLDKLAHSEAFDTLFKQAVASAVSSRRYELLVSDEMCDPDEVRSILEEDGAFLSQDNNCKLLYTENPLRIYANGEWLDELNIIESEVLKRLSDGESLDWAFLSDLANKTEDPETSMDLLLDSICNWVDDGWALIE
The following text describes a protein:
Function:
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis; Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MISMDPHNEEAYSIVVFGASGGLAKKKVFPALWALFRENRLPQGTKIFTFTRSPLQTKTYRLQILPYMELDKHRDPKKYNLFWTTVHCVQGEYDKPENYVALTEAMVHQETKHNQVRANRIFYLALPPIVFDQVTLNVSRKCSSTTGWNRIIVEKPFARDDISYKAFQTSLCNCFRESQIYLMDHLLSRQVMQNFFALRYSNHLWAETLNHRHVAAVMISIKCELPVSVNRADYFNQFGIIRDLMTNHMIQMLAMLAMDQPYANTADDLRAERLKVLRQVLTPNIGDVVLAQYRNNRRETDPAKCGYTEHTYIPKDSFTPTFALVVLHINNRRWTGVPFILRAGKALNDTKSEVRIQYKPVDCDTFHSDSTDIRNELVLRSFPTEEVFMRMRLKRQGEDICLRESEINLRVDDRGPKGLQGLPGYLLNVFQGDQTLFMRSDEQCEIWRIFSPVLATIDSDRPRPLHYDFGSRGPLLAYRKAERAGFVFFATDEWHQSEETLEYTVKNSKQLIGPHTALKPVRDPRSKRSNSNP
The following text describes a protein:
Function:
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MWYFVALCVVLLLLWLHLDNLKPLNFPPGPKWYPIVGSALSIMNARNKTGMLCKAVEHIAQDYPDHRGVIGFKIGKDKAVMAINAESLKEMMNNEDFDGRPTGIFYETRTWGLRRGVLLTDEQFWQEQRRFIVRHLKEFGFARKGMTEIIQNEAAHIRKDFEEQIAKGQGKATVQMQGAFSVYVLNTLWLMMAGVRYSKDNDDLRYLQALLHELFTNIDMMGALFSHFPYLRFVAPRLSGYRQFVEIHECMHKFIGAEVERHQKNFNPDDEPRDLMDVYLHTLQNNNAPSDSFSREQLLAVCLDMFIAGSETTTKTLDFSFLYIVRNPKVMRRIQEEIDDVIGRNRLPTLEDRASMPYSEATTLEGLRLFMSNTFGIPHRALKDTTLCGYHIPKDTMLVGMFRGMMLDENLWENPTQFNPERFLKDGKIHIPAQYHPFGVGKHRCMGELMAKSNLFLFLTTTLQSFDLLLPDGAPIPSDIPIDGATPSVRKYHVAIRARH
The following text describes a protein:
Function:
Essential protein (By similarity). Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication (By similarity). H3K4me3 effector that positively regulates the transcription of a subset of genes (By similarity). Required for cell proliferation.
Subcellular Localization:
Nucleus.
Sequence:
MDLSATPSRSKSGLRSSPRKPVAAPAVAQMDLSTPSKPTPRRKPKAPPVAAPMSPVTPSSVRRSSRLLETPTKVTSETPVKPTPTPKRKRAAPSPSPKTPTQSEPKRQRQRQRQRQQPKKPKKRAYYRKVVYDGGEFAAGDDVYVKRRDGAESDAEDPEAEECRVCFRAGAAVMVECDVCLGGFHLRCVRPPLRRVPEGDWACPYCEAERAGKAIERPKPPEGKRIVRTAKEKLLSSDLWAARIESLWREPDGIFWAKVRWYIIPEETAAGRQPHNLRRELYRTNDLADIEMETILRHCYVMSPKEFKDASDQGDDVFYCEYEYDIHWHNFKRLADIDDEPETKEDPGDEPYNAGNDYVSDSDEDSEYDEEEEPTKCSSARTHQSHALAANLRKGRTYGLQKIGIRKIPEHVRCHQKTNLEKAKATLLLATLPKSLPCRDKEMEEISAFVKDAICNDQCLGRCLYIHGVPGTGKTMSVLAVMRRLRSELDSGNLRPYSFIEINGLKLASPENIYKVIYEQLSGHRVGWKKALHYLTEHFSGGTKIGKQANQPIILLIDELDLLLTRNQSVLYNILDWPTRPNSNLVVIGIANTMDLPEKLLPRISSRMGIQRLCFGPYNYRQLQEIITSRLKGIDAFEDQAIEFASRKVAAMSGDARRALEICRRAAEFADYRVKQSGHTSVNRGKNVVCMGDIEAAIQEVFQAPHIQVMKNCPKFGKIILVAMVHELYRSGLGEVMFDKLAATVLSWCHVNRELLPGYDTLLKICCKLGEGKIILCEEGTKHKLQKLQLNYPSDDVTFALKESPDIPWLSKYL
The following text describes a protein:
Function:
Acyltransferase; part of the gene cluster that mediates the biosynthesis of helvolic acid, an antibacterial nortriterpenoid. Protostadienol synthase helA cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol). The synthesis of protostadienol is followed by several steps of monooxygenation, dehydrogenation, and acyl transfer to yield the final helvolic acid. Following the cyclization to the tetracyclic protostadienol by helA, cytochrome P450 monooxygenases helB1-mediated and helB2-mediated oxidation at C-4 and C-16, acyltransferase helD2-dependent acetylation of 16-OH, oxidation of C-21 by cytochrome P450 monooxygenase helB4, and short chain dehydrogenase helC-dependent oxidative decarboxylation yield the fusidane skeleton. This intermediate is further modified in three additional steps mediated by the cytochrome P450 monooxygenase helB3, the acyltransferase helD1, and the 3-ketosteroid 1-dehydrogenase helE to give helvolic acid. Compared with the late stages in the biosynthesis of helvolic acid, enzymes involved in the early stage modifications act in a relatively strict order. The hydroxylation of C-16 by helB1 and subsequent acetylation by helD2 should occur before the helB3-mediated oxidation of C-21. C-4 demethylation in fusidane-type antibiotics proceeds in an unusual manner though it is also achieved by oxidative decarboxylation. The methyl group at C-4 beta position is oxidized by helB1 and subsequently removed by the short chain dehydrogenase helC.
Sequence:
MEGLNISNQVFDLSPLDIIPSHLYITNAFFYENKTPGPRPFMQSSLLKESLYRALQNFPILLGHVRRHRRNAMQIVVDCDNLNLPLYEEQTHPQLHFRHLKDHQFHRDVWPKDANIIDPRASPNGELLQVHVHRLAEESGVVMVVRIAHCAVDAKGFVDFMQSWGWFARNHSHPEGDSWPRLLADRRVMYEYLPPDVQPAAPRSMWHPASWLLGLLSTLVVLFLGLYKRLLGDKTPPDEIESHLFSVPPHTLDRLRYTATCIDPSSRVSDHDIITALFTLAFAHTKHLLTCRTQTVTAIVPCDFRHRIGVPSNFTGSCAIGLYVSIPGSLLQTPLTAESVARAALLSRAVVDTADKVTIQTFIRRALRAIAFVGDKVNVLYATMVSQAFSNQSRLGFYEVDFGAGGPVMVAPMAYSNTVAVICPAPGPGGDGVGVRVFLTLRPEVMRMLLAKGFLDEFTDMIY
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Subcellular Localization:
Cytoplasm.
Sequence:
MAHPKDHSKMGFGRSIAVLTSGGDAQGMNAAVRATVRVGIYTGAKVYFVHEGYQGLVDGGDNIKPATWESVSMMLQLGGTVIGSARCMDFKEKWGRLKAACNLVKLGITNLCVIGGDGSLTGANQFRTEWSELLADLIKQGKITAEEAKRSSHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAITTTAQSHQRTFILEVMGRHCGYLALVTALACGADWVFIPEMPPEDNWEEHLCKRLIAQRERGSRLNVIIMAEGAQDRKQKPITCDQVKNLVSKKLGFDTRSTILGHVQRGGTPSAFDRILGSRMGVEAVMALLEATPETPACVVSLSGNMAIRLPLMECVQVTKDVTVAMAEGRFEDAVNLRGKSFQNNWNTYKMLAHVNPPEVKSNINIAIVNVGAPCAGMNAAVRSAVRAGLIQGHQMLAIHDGFDGLANGQIEPITWAQVGGWTGKGGSNLGTKRNLPGKNIEQISLNIAKFNIHSLIIIGGFEAYLGGLELVTAREKYEELCIPMVVIPATVSNNVPGSDFSIGADTALNTITMTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLSSGADAAYIYEEPFHIHDLELNVVHLIEKMKTSVKRGLILRNSNANDNYTTQFLYNLYSEEGKGTFDCRMNILGHMQQGGTPTPFDRNFGTKMGAKSVLWLTDKLKECYRHGRIFANTPDSACVLGMKRRSLIFQPLTSLKEDTDFEHRIPKTEWWLKLRPILKILARYEAVEIDTSEVAAMEHIIKKTGEIKGGKI
The following text describes a protein:
Function:
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids, and plays a key role in the quinate degradation pathway. Catalyzes the NAD(+)-dependent oxidation of both quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate, respectively. It can only use NAD.
Sequence:
MNHDSILLGLIGEDISLSRTPAMHEAEGLAQGAATVYRRIDTLTDRARGRSLQELLDAARSTGFNGLNITHPYKQAVLPLLDEVSEQAAQLGAVNTVVIGEDGRTSGHNTDVTGFARGLEEGLPDATMTTVVQVGAGGVGNAVAYSLVTHGVEQLQVADLDPARAQALADAINSAIGREAVHGIDARGVEEAIAAADGVVNATPMGMLAHPGTAFDTSCLTPHHWVGDVVYMPIETQLLKDARALGCRTLDGTRMAIHQAVDAFRLFTGLEPDVERMRATFLSL
The following text describes a protein:
Function:
Catalyzes the exchange of ADP and ATP across the membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLPLQTKETHGMATQSERFSLDFLMGGVAAIIAKSAAAPIERVKLLLQNQGEMIKRGQLKRPYTGVGECFGRVLREEGLLSFWRGNQANVIRYFPTQAFNFAFKGYFKSVLGRSKEKDGYIKWFAGNVASGSAAGATTSLFLYHLDFARTRLGTDTRDDQRQFKGLLDVYRKTLSSDGIVGLYRGFGPSIIGITLYRGMYFGIYDTMKPIVLVGPFEGNFFASFLLGWSVTTVSGICAYPFDTLRRRMMMTSGQPVKYCNAMHAFLEIIRLEGFIALFRGVTANMLVGMAGAGVLAGYDHLHRIASRHGYN
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. It is an AMP-binding protein that may facilitate dynein ATPase-dependent ciliary and flagellar beating via adenine nucleotide homeostasis. May function as a donor of AMP to AK8 and hence promote ADP production (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cell projection, cilium. Cell projection, cilium, flagellum. Note=Located in the proximal region of respiratory cilia.
Sequence:
MPLSTAGVLSSASTASNRSRNRPRYRTKALSSEVDESLFGAIKPLTRSDSPIVLLRDKHAIRKTLTALGLDHKPETIQLITRDMVRELIIPTKDPSGQSLIMSPEEFERIKWASHVLTKEELEAREQAFKKEKEAIVDTVTTRKKIMKQKEMVWRNNRKLSDLEEVAKERAQNLLQRANQLRMEQEEELKDMKKIILNAKCHAIRDAQILEKQLIQKELDAEEKRLDQMMEVERQKSVQRQEELDRKRREERIRGRRHIVEQMEKNQEERSLLAEQREQEKEQMLEYMEKLQEEDLRDLEQRHQQKLKMQAEIKRINDENQRQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENAQKKMETEAKLRKSRLEQVAFKEHTLAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKQVQARIATFDEGRRLKEEAQKRRERIEDIKRKKLEELRATGLPEKYCIEAERKANIPVNTSVN
The following text describes a protein:
Function:
Has no photolyase activity.
Sequence:
MEKINLVWLKRDLRLTDHAPLQAALTSGRPTLLLYLFEPMLLGDAHYSERHWRFVWQSLQAINRDLAQSKGEVLIVTSDWQTCFARIAERYAIEAIYSHQEVGLACTFQRDLALAQWCQQHDIVWHEFPYAAVIRGAQTRKNWDEHWQQVMRSPCCDPDLTRANWLKLDAATLGLRSDIPATWQSKQAGMQTGGSDMAWATLEDFFARRGREYYRSISSPSLARHACSRMSPYLAWGNISLREMYQTLLKHWSVAGFRRSLIALSSRLHWHCHFIQKFESECEMEFRCVNRAYDSLLQQSSDAPAAQLAAWQTGHTGIPLVDACMRCLIQTGYLNFRMRAMLVSVLTHHMNVDWRAGVTYLAQLFLDFEPGIHYPQFQMQAGVTGTNTIRIYNPTKQAQEHDSEGQFIHKWVPELAQVPVPLLFEPWLMTPLEAQMYQVPLESPYLKPVMDLEASAKQARDRLWQWQKLPAVQAEAMRILARHVRQAKPRTSPRQPNKRQPEMD
The following text describes a protein:
Function:
Serine protease involved in intramembrane proteolysis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSNIHTLAEYRDDYAENTPFNRTPDYYQSQSSFVQRSKPIDLLNLIFPHFTWKSFMVVISIIQLIVFIISVSIKPADFLTPSDSLLVTLGANVASRIKQGEIHRLILPIFLHANIFHAIFNIFFQLRMGFTLEKNYGIMKIIILYFVTGMYGNILSSSITYCPIKVGASTSGMGLVGIVTSELILLWHIIRHRERVVFNIIFFSLISFFYYFTFNGSNIDHVGHLGGLISGISLGILYNEHMDNKPRWYNHLKIGSYISLVLLAIIPTVVLFTIPRTC
The following text describes a protein:
Function:
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network. Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network. Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
Subcellular Localization:
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Sequence:
MSARKRVKRASAYDLYRTCKQAGTCPPDVIPKVEGDTIADKILKFGGLAIYLGGLGIGTWSTGRVAAGGSPRYTPLRTAGSTSSLASIGSRAVTAGTRPSIGAGIPLDTLETLGALRPGVYEDTVLPEAPAIVTPDAVPADSGLDALSIGTDSSTETLITLLEPEGPEDIAVLELQPLDRPTWQVSNAVHQSSAYHAPLQLQSSIAETSGLENIFVGGSGLGDTGGENIELTYFGSPRTSTPRSIASKSRGILNWFSKRYYTQVPTEDPEVFSSQTFANPLYEAEPAVLKGPSGRVGLSQVYKPDTLTTRSGTEVGPQLHVRYSLSTIHEDVEAIPYTVDENTQGLAFVPLHEEQAGFEEIELDDFSETHRLLPQNTSSTPVGSGVRRSLIPTQEFSATRPTGVVTYGSPDTYSASPVTDPDSTSPSLVIDDTTTTPIIIIDGHTVDLYSSNYTLHPSLLRKRKKRKHA
The following text describes a protein:
Function:
Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
Sequence:
GGHTMEMMEILKDIDCQHFSPRHYIIASTDQTSEGKVILHEQQIQSQTGKNQIYTISKISRSRQVNQPWISSIFSTLWAAWFSLMIFYRLYPDLILCNGPGTCVPIACIARLTQLLGISRARVMYVESLARVSDLSLSGKILYNIVDKFIIQWPQLKTKYPKSIYVGRLV
The following text describes a protein:
Function:
Probable glucose transporter. Involved in sugar transport, carbon catabolite repression, and initiation of conidiophore development.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAIFAMGWQKPDNVAGSSAPAIMVGLFVATGGLLLGYDTGTINGILAMKSFKDHFSTGYIDGNGQPGIYPKESALIVAMLSAGTAIGALLAAPLGDHYGRRRSLIGAIGIFVIGAILQVCAYNIDLLVAGRTVAGVGIGIVSVLVPLYQSEMAPKWIRGTLVCTYQLSITMGLLAAAVVNILTYKLKTAAAYRVPIGLQLTWACVLALGLTVLPETPRYLIKRGDKNAAALSLSRLRRLDITHPALVEELAEIEANHQYEMALGPDSYKDILFGEPHLGRRTFTGCCLQMLQQLTGVNFIMYYGTTFFNNAGVGNPFKISLIMQVINTASTIPGLFVVESWGRRRLLMVGAIGMAICQLLIAAFATASGSNNLSAQNKVLITFVAIYIFFFAASWGPVVWVVTSEIYPLKVRAKSMSITTASNWFLNFGIAYGTPYMQTNSAASDESSIDLGSKVFFVWGAFCIVAVGFVWCMVYETSKISLEQIDEMYERVDHAWHSRRFEPSWSFQEMRDLGFSDGGIPPTQQLQQQPQQPQQQQQQHHQQQQHQLQVDLQQSQSRTSNSSTSQTDTGGSNNTGASQDDKLVASLGNIDLSY
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. This subunit may anchor the endonuclease complex to the nuclear membrane. Probably carries the active site for 5'-splice site cleavage.
Miscellaneous:
MISCELLANEOUS: The tRNA splicing endonuclease complex is present with 100 molecules/cell; MISCELLANEOUS: Present with 319 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=The tRNA splicing endonuclease complex is predominantly associated with the outer membrane of mitochondria, suggesting that tRNA splicing mainly takes place on the mitochondrial surface.
Sequence:
MSKGRVNQKRYKYPLPIHPVDDLPELILHNPLSWLYWAYRYYKSTNALNDKVHVDFIGDTTLHITVQDDKQMLYLWNNGFFGTGQFSRSEPTWKARTEARLGLNDTPLHNRGGTKSNTETEMTLEKVTQQRRLQRLEFKKERAKLERELLELRKKGGHIDEENILLEKQRESLRKFKLKQTEDVGIVAQQQDISESNLRDEDNNLLDENGDLLPLESLELMPVEAMFLTFALPVLDISPACLAGKLFQFDAKYKDIHSFVRSYVIYHHYRSHGWCVRSGIKFGCDYLLYKRGPPFQHAEFCVMGLDHDVSKDYTWYSSIARVVGGAKKTFVLCYVERLISEQEAIALWKSNNFTKLFNSFQVGEVLYKRWVPGRNRD
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MECDKVKDENLESFRATAITALEREREEREVEKEVKMASGWGITGNKGRCYDFWMDFSECMSQCRQPKDCGLLREDYFECLNHSKEFQRRNRVYKEEQRQLRAAAEKAKGGGVDVHH
The following text describes a protein:
Function:
Cleaves the beta-phosphate at the 1- and 5-position of soluble inositol pyrophosphates. Has exopolyphosphatase activity in vitro but does not appear to contribute to the homeostasis of cellular polyphosphate.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAIVFPFQLEKKLISITSDRDQISMSIPEVSSHDSCLNDCHSVNSEEQAKPVCCLELNAHKDGIKVVDTSNDASTFSNSPLVPDNFGVVYPGIIYRSACPRASNFNFLESLHIRTIISLRQEEYSEEDLHYFTKHHINYYHIAMPGSKHRKNDCISSSSNPDISDVDDLVRKTLQLLLNKENWPVLLHCSRGKHRTGIVIGCLRALMNWPVGNRLQEYISFSHPKEREVDEEYIQNFSSDPSLKSSLNDLKRYISDSSSELADVVLSSESPTVQAATVNETCRSPGS
The following text describes a protein:
Function:
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
Subcellular Localization:
Mitochondrion.
Sequence:
MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNKVSEEHDVLKKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGFGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKRDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKAKFESMAEEKRKREEEEKAQQVARRQQERKAVTKMSPEAPQPVIAMEEPTVPAPLPKKISSEAWPPAGTPPSSEPEPVRTSREQPVPLLPVRQTLREDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEGSSFSSAPAGSGCPVGAGTLGISAVALYDYQGEGGDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDFNDKLATLTRVCLARRVSAGRFVKLTRHLMENEGASEVNPKALFGANTFDLLFFAYVHKLAFEDSLLPPYKLLAYLKVCAYGRLPQLLMYLGKQLQEMDTDVDLGANAGYSYLIQVLVSFMKDAFASGGGMRKRYGTSIAKGFGFFAEVLLTRLGDRMAGVTAPEITSQLAELAKVDATIAGRLGEAWMGLKGAAKTSTTAETVAATVATPTTLTRLYRDTLFESLMFGDSSWNQYGSLFQLISTVYAMPGYPTLASQPVQSRLAIIGEVICAMFDCQSITFLRRDSAKRNNYWKSCIRTRIPRIIRTLFPHSTPEEKTLIQSVVSKSVLGLDQPTVTLIRLSIGSDELDDMFSSFPGGLDVDIRHELVAACISEGVLPKDAFNAIFKDSGISVEALDYADELTIDGQAMSLDTMAEQLSYENLEIGSVSDCLMSKVVAQMEKLSGNAQEALTKRLLVCLADFVQAGNVRPVRYMCQALALNTTAVDIMALCVDPMLLLKALVDCIELWREEEDEANYQEAYTDFGAIVVFAITLKQRYHLDLALLNQFGTLFVGAPSPSSTMPSHELFLSQLLTESDSSQRIFHLSDEQNDQLSGWATALYDAGGISDDLMRSSSVKQFFLVTPAIFQQSMLAHEKGLLSLSTFKGGLEYFLQPFLLGSTVGVFKWLSEQLWVHSQKGHDEQMSTVISVCSTLILTDNTDIEVLSPIHQMVLAICADEMYEALDMALRAGYMVENRVFEFLEPFVSAINYNLNVQRTVSSSGFRSQKGIGMSGGGGSGTKEQTWKYGASMIATIKEQVSSLISWSQNQYTGPPFGYELVMILSSVDTLGHKYVLEQLIEEIALADSNGTGHYTVEVVATIATVAFIISTSVKSPRPFSDSQLILKSLDNMVNDSTGKSKDICVLLQSKILQLLTTAGYKPDGSRLDGKPHAKEDYSFVVNRTGEVENKPINDSSQNSNTDNQFMDTNMFGGDDFTMDFGGDIDMPDLF
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
Sequence:
MSTVFIDRKDIEIRVDGNSISFYAKGKKDGSLPLSPLKRVVIVGNVKIETSVLYKLVNHGITVLFLTGKLKYSGILNGPLHNNGLLRVKQYQKSLSGFSLKFAKELIKRKIVSQRDFLSEIREIKKALAMQADRAIEILNKAISNIEVTPISIDSLRGIEGAASSIYFITYSKIFPNSLKFVRRIKRPPKDPVNAMLSLCYTLLHYEIVREIQLIGLDPTIGFYHQFEYGRESLACDLVELFRVNVDRFVYELFKAKHLGNRDFMKDEESGGVYLKKTGRKKFYPLYEQWVQQQRTIWRGEVQGFARRILEEKDIISG
The following text describes a protein:
Function:
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).
Sequence:
MGKKYADKAQFILIYIKEAHASDEWPLDYLNDSMDVSFKKPRVLEERMSLAKQFIDRFDIKLPVYVDDIKDTMAKEYSATPERLYVIRDGKISYKGGPGPMCYDLDELESHLQEL