lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVNFASEVDKNNAFDSAHPSRKCKGSLDCNDPDPIFRHKVLVIIHKLAISSWNRIPLTLCNKLHIKRISGALTNAVYYVAPPEGYHAPKLLLRIYGPHVELFINRQVELENLKRLARHNIGPYLIGEFSNGRFEQYMESTTLTCKTIRDPKLSIYVGRRLCELHNFILLHPHEVLEMPAAWKNCLVWLPKAKAKILGRKHSLAITSEFMKTLEEDFNAYYNWFVEWSRDKKDWFGLKMVFSHNDTQYGNLLKIKAKKRSIPLSQKHRTLVPVDFEYAGPNLCAFDLANYFAEWMADYHHPTHNYLMDRSRYPDFNARKLVYHAYVEQSAVINDLLEIEDASLLKTDISDELKNTFEKQIMNLEESVRAISPAANIGWALWGILQCLEEDDEWEDLSVSSQVADRPEKQLVEGSTVPPIGTSSFDYIGYSSEKFDLFYEGCAALGLNGRNRSTFSYA
The following text describes a protein:
Function:
Acts as a co-chaperone for HSP90.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLARKIFNCENLLKEYNNAIQALQHERGKLLNNAPQLKPWQSRDTLPFQLQSIDTQVREYQLLISSNDLKLRQLRNENVHGVCPIIEWAETINHVYLRICYPNVKDQKIIFEDDKTCLVTCIAGEGQRLCRLKLELTKRVNRVATKVDIGDTVINCILSKEERKLWRTLVEDERTDHYLIQCKGEDWISQFCL
The following text describes a protein:
Function:
Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A.
Subcellular Localization:
Cell membrane. Note=The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells. Membrane localization of the Sca1 complex is regulated by scaA phosphorylation by PKB and PKB-related PKBR1.
Sequence:
MSSLDPSLSTTPSTNRRGTFSKAKSFRRAALNLEPQGTPGQPHAFRFLSGEEYSGPDIIENIKKPININIESEEYKTPLFLGANGTLYNKYYIPIKIIGIDEPLPQTGLSPSLSSSSSSSSSPSPPTTTSTTPPPPNNNNNSKQIKKNNSISDLTPYLNFNSTDQIYTSFPESMAFDDYMDYEESLVEWKRQVEQNLGIIQLPHSIGRTYPRPKVIHEQLFRKNSEASNDDSISYDIERKLTDSDIKETNSSVNDDGESFSHSPTLRGNNGSSLSVGGGGDNHDNTSNKDNASSQGTNHGVTLNHPNSGINLRERSNSDTSTGSFEGTQLDGSSPMDGSPSTGSLAGFVANGTRSRTNSITYFDQRNQRSNSLSPKHSMLQSRLADSQSLDSSMYGKMGRSGSGFGMDHESWFLQKDPWDSQLILTEPHPDLFSTYEEYEYAMKNWAHEVITKTSILPPHPGQFIQLPKNSELSTDDGSGGGSGGSGVDGVGGNHQLGGSARHMLEMDFEMAKNQSNWTLRPIIRPIITEETMIFNRILSQSNLKHTEYDHLFSIDQELPPSQVWKTLDSDEKLKITETIDRWYRKKLTIQRQTSTWFRGGLWANHFLMPNIQSGWRESVSKKSSILPPLSLKALRRLDINSEADGKRVEHSFPIPELPINFNKLLAPDMNLQYFLGMLEMPTAHSLSSATGGQQQGGSGGGSGGSGSGSGSGSGLNMSGTSGSSGKSEKDKDKETANYIAMHSINNTTNVGTKEDRRQYTKILQTYEQRLQFSFRLDALNSWSEGGYTPMELQEKKLDIEQLVAAPGFDLQNGVWSLVNNSAHFLDKFQETFDQVDLRLYAPAIPMLPAIVPSVFINAGGGSGGGSGGASGGGISTSSGTSPNIVRPGSSSIGGGQPPSSPHIPSGSSLLSSPPNRQGSTGSFSFIGSPGGGGKISPTNSSSLESPRTQSQLAAVVERGSSPRSHSGGSISTHPNTPSVSSNTFLSLINTDSFPELLKFLDLTNEKLALGKISSLVLLVLTSELKGTMVIENILFSKDLQSLYRLARAISFFDAVPLDLFTYPTHLNEMLTPSIFKGSTQEVVRLVFVYYYLGIIQERLNFFSNNVGILGFVNSSRKDAAERIGIQFQNDREFLYKIFKALGRKSILVSNCFLFVLIQLIKMSESPTVQSLLKGELLTHIRDLSASKFSHSRFAAKRLYQILQEDPWKEFLMASYAESIKKNESQHLTDLTTMKEGPKLAIPSISLISELTFNFCVGVLENINSTPIPKPIYKFILNDSIFFQLCNAIVKCKNFTQSTQIVSKVFASLCKVLAKFNLFKNSDSIKSGGKVDPKKQNDVETGVAISPTLLFEIIGFLQNSSLDNNRYCSIIKTNMLIALRQLLKQSEIFDSIKKEGNLYNKFLIPACRDGKNVEFNRNVWRLFFQMIRFHHGHIEYLEKSKYLNALMDIISLNAGNVVLTNALHYLSKLFSLVSYETRKNALRAPGTLSIDTKYSEKDVKSLLNFFVERSCFIKFHMIYKKLTENTEGIQIDQRLLINITTFYRIISFLPSCQKLLKDTLKNPEYKTGIIQVSKMYKPSETF
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
Subcellular Localization:
Cytoplasmic granule. Nucleus, nucleolus.
Sequence:
MSTTPSKRYDEKINTVDRRPPVKPCEEPNHIYITRKTNVESQAKTAEEMLNNSFDEIYIHGMGASVNKALVFAMEVERKFGGSVKSDIQTSTVQCTDDIISLLDLDQTDTRHRSVSAVHVHLYRAAS
The following text describes a protein:
Function:
Specific kinase that phosphorylates deoxyadenosine but not any other deoxyribonucleoside, as part of the deoxyribonucleotide salvage pathway.
Miscellaneous:
MISCELLANEOUS: Can also efficiently phosphorylate medically important adenosine analogs, such as 9-beta-d-arabinofuranosyl-2-fluoroadenine (fludarabine).
Sequence:
MTTPILNSSVPGNIQKKSLEGTHIAISGLIGAGKTTLAVALGKVLNLPTYFEEVIDNLYLQDFYKDPKKYGFQLQIYLLNSRFQQQQQIIWQARGGVQDRTIYEDSVFAKMLNESGLLDDRDYNTYCKLFQNLSNFMRRPDLIIHLDVSPEKSLERIKLRNRDCEKDVSLEYLQNLYNAYHEFLQDISRYIPVIRINWSEFVDPEQLAQMIKAEYESMRFMNQINPPTFGNGPTTNKIISTPKDL
The following text describes a protein:
Function:
Binds the poly(A) tail of mRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MATTTAAMAAATVPMGSVAAGSGFMNVSLYVGDLEQNVVEGQLYDLFSQVGTVASLKVCRDQNKRSSLGYAYVNYSNHQEAAHAKEIFNFTLINGKPIRIMFSQRDPSIRKTGYANVFIKNLDPAIDNKALFDTFAAFGTVLSSKVATDNNGQSKGFGYVQFETEEAAQNAIKRLNGMLINDKQVYVGQHVRRQERVPPNASPKFNNVYVKNLSETITDEDLKKVFGACGTITSAVVMKDQNGKSRCFGFVNFQSPDAAAAAVEKFNGTKNDDKMWYVGRAQRKAEREAELKARFEQERISRYEKLQAANLYLKNLDDSIDIEKLKDLFSEFGTITSCKIMLNPQGVSQGSGFVAFSTPEEASKALIGMNGKMIGKKPLYVAVAQRKEERKARLQAYFAQLHTHGAMSPLGSGIPGFHPAAHRLGPQQLYYGQGGPGLIHPQSARYGFQQQLLPGIRPSVTQNYIMPYNLQGQGQSGQRMGVRRGGNSQQVQQKQMLQRNTNQGFRYMGNARDIVDPSTVTQSIVGPVMQLPLEVSRMPVNPIDLQQPNPVPISTLISDLASASPKKRDEMLGEQLYPLVQRFEPEHAGKVTGMLLEMDQTEVLHLLESPDALKEKVAKAMAVLQDSAAGESGVRKESGVIGAD
The following text describes a protein:
Function:
This protein is probably a component of a manganese permease, a binding protein-dependent, ATP-driven transport system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLFLEGLMQYSFLQKALITSVTVGIVSGVIGSFIILRGMSLMGDAISHAVLPGVAISYMMGMNFFIGAATFGIAAALGIGFVNQKSRIKNDTAIGIVFSAFFALGIILISFAKSSTDLYHILFGNVLAVRSSDMWMTIIIAIIVISLVALFYKEFLVSSFDPVMAEAYGLNVKFLHYFLMLLLTLVTVSALQTVGIILVVAMLITPAATAYLLTNKLSKMIVLASTFGAVSAIIGLYFSYIFNLASGAAMVLVATIIFFIAFLFAPKQGLLFSKKREVIE
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MVDAGIIVPYQGNCNGTGSGAGAGARHENHANGHTSEYTVRHGLPGTPRIQISWGTGNLLRLSFLPSTEERQEIGKVVQVQLGQGAGDGQAGAESRRIATDSFPFFVELQSQRRQQNNETLQGGSPNNWWEYVLEYSRNISDMLGSSERPPSSDLYDTTKENKTTAAMRAIWDMLEIFYVDKSAESWFPERLVDWLVAHGPILSKTEASLSRRLIEIKRRLSIRQFPEEESDYWEGIASALAVGWFDFVVTFLRMHGSYRHDQIDKRQTENGLVEAVAVLVSMMPRLRPSLPPGSPGVAYSFKPEFAKEWERWRIQVTKLDRSAFWNECHNQKTLQGLKKLLAILQGNVEVLVKSTYHWMELLTAHYLHVRPFAIATEGLVALANTCKEYKGTHKSDELQELILAVLGDNTEVVIAECVRLFEPWMMAHMVELLTAKDSYVQNLLRKERDVQGGISLEELYRLSYAQSLASDPLTWQVAPVYLASCPGQGLGMLETLLLRLPVSDDSRLAQKALDVCRLYDLQAVGTTICRKVGVHSWKHGRIGAGIVWLQRARDKRLLSALSDQLLASVSTGSTWGHVQDFEQIQGLVDLLGTDFQATGGLSILHRYRNFKSAMQNVWDLRSKETDKQKLSAAGRQAVDCLLELFKVGITPKRFWMSILQDSVELLEWPEQVLLNAQETNTLLNCVQELKLAKLWGDVDSVDEPGSNVDRVRLALATNLGRSFLQV
The following text describes a protein:
Function:
Deacylates the non-reducing end of diacetylchitobiose (GlcNAc2). Can also use N-acetylglucosamine (GlcNAc) and N-acetylchitotriose (GlcNAc3). Probably involved in chitin degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MVFEEFNNFDEAFSALLSKLDFKINEPFNDVKKVLCIEPHPDDCAIGLGGTIKKLTDSGIDVVYLLLTDGSMGTTDGEVSGHELALRRLEEEKRSAEILGVKKIHALDFGDTELPYTREVRKEIVTVIRKERPGIVLMPDPWLPYEGHPDHRHAGFLGIEAVSFAGLPNFNRSDLIAGLDPHSIQAVGFYYTHKPNYFVDISDVMEVKLRAVRTHESQFPEDVWELWEPYLRTIALYYGKMSGHRYAEGIRFVPGIFLHICPFAHVI
The following text describes a protein:
Function:
Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MLGTWPSLRQQQHRTHLLPHWRCGVPEVGVDYWGNDIADIASLKLPEECCNRCADTLGCKAFTFISAGWDGKTHCYLKNGVGAKKNIASAVSALVTSPRVASCSTQVGGYCGNTDWSICCSYGSYCQPWNAGYYQCIKAPKHCSTQLTDVDFYGNDLGVVYGLHPTGCCDKCTQTAGCVGYTFVNSNPGQTACYLKSSIDGKRRSVGAVSGKVDLTGVSHIQAKIRRGEARSRAVNLGAWLVTQGELAVMGYLGKTEGSAAFEDHWQTWITESDIKDIANTGVLNTVRVPVGHWIIRDATDSPGEEGDIFASGGLKYLDVLINDWAVKYDLAVIVSLHAHQGSQNGYAHSAPAALGTVEWSTTQTNVDNSLKFATFIAERYKDSPAFLGLNLMNEPAPPTDRKVLIQYYVEAYNRIRATGNNCIILVSPLASDQGPRGFDGMIQAPEYDNVWNEIHAYFIWGYEDKSEEWILDHLDTYKKENLQLEPKSNRLFVGEWSMGGPPDDKGMFQDIGCFHELGRKQLVMYNEEATGGWAFWSWRHSDETFNWSMRTLIQYNGLSFSFELS
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.
Sequence:
MSDYRSSLMSSFRRIPPSAIPATLDCILASNTSPPSSLFSLLLDAFPTLSQELTITIGGFSDEQCNLIASYVGALSHLLKKPGLDVEALQNFVSRVFIPLTQKNYDRLIVDKAIASFLDVVMETNAWGVVEETVVPYFMKSVGLTMGGTLENEQASEDSALTTSDSFSLFMACHILASILDASVKGNHASESTNGCDLHTFTGNLVWDICNVTLQMLSHSPEHRSCALAVFLPRIFESICNALEISVHGEKLILFRTTFFAKIWKCCKNLFIMGSSERRDAYSILSLYISYSSKGEVCENDSVSGDVTYYLRAEKDFWDEMKKGLVDKEHIVRKQSLYILKSTAITCETKQKTSVSETTSNSHGLTKRERWANKEAKTLGIENLCDSIDSDSTSQRKWGAFFLLYEMLEEYGTHLVEAAWNYQMNLLLHTSHPCDNPIKPVDPMETLEDMFDWLAVLWQRGLCHDNPQVRGLIMQSVFGIEWKNHGNYAKFVPRSFVLGPFMQGLNDPIHHKEFGLKGVYSSRTIEGASIFMQQYTACLSEGEQMPFVSNLASLVKNYSFGRAGLMSLAECVAAAAAGQNEVGLSDEDCTYNDKAALLDVFRFIIESSKQHFNPNYRRQVCGKILDATVSVMSSSDVPFETLVHFISSFPPDFLNYGGLLREKVQEWIRGYERKAFNGVKLMKKLNEFPISFIKHNNHPTSDIVNYDDEDLETWELQAKRWAQTLFLIIQEEHQLDSQLQFIHTHGNDLCKMNVNGEWLPVKYMILILSIIEELHEMNNRKVVNASIIVKNFTESFTFILEELASYTKRTCSVFWSEECGDTNLPSSIKGRLGGLSQRRLPSSKTTAVLQAIISVKTLASIALYCAQFKEDKSFFSALDVLWQLSWKIISCPTSNSETKAEIYLGGYEALHFILKSLVLMPSSSSSSALSLLTRPYNNSEVKPHIDYFVQIFLGNINNLIEAGYLTRARRAILIDWKWMCLESLLLVPQRGGVYTQNCDYFFSDAVVKRIFSDLVDSLENAGEGSVLPMLRSVRLALDFFAVSSCDGIDVQMMWHLVRSSWLLHVSCNKRRVAPIAALLSSVLHDSVFCDMDMHEHNNIPGPLKWFVEKLVEEGTRSPRTIRLAALHLTGLWLSHPSAIKYYMKELKLLTLYGSVAFDEDFEAEVTENHDARTEVSILSSSSDPELTEVFINTELYARVSVAVMFNKLADMAHATGSKNEVENSHASLQSGKLFLLELLQSVVSDTDLAKELYKKYSATHRRKVRAWQMICILSRFVDEDIISQVMDHLHTALYRNNMPGVRQYMETFAIHVYLKFPLLVGEQLVPMVRKYDMRTQALSSYVFIAANVILHATKDTQSRHLDELLPPIVPLLTSHHHSLRGFTQLLVYQVLSKLLPSINSYANGTLPLEKRCFMELKSYLEVNSDCARLRVSMEVHLDAFDPNKSITPAGIFSNRVDDIEFECAHVSLLERVIDFLNDVRKDLRYSMAQDAAQLKSEQMHMQDPESTSQLKEETTAKMKNDLSLDFQKKVVISKHEKQDSHFNDAYNSLLDVEKEDVLLDQSMRARNIAMGKLKAGRQQIILVASLVDRVPNLAGLARTCEVFKAASLVVDNVNILHDKQFQLISVTAEKWVPIIEVPVSNVKGYLEKKKQEGFSILGLEQTANSVALDQYVFPKKTVLVVGREKEGIPVELIHILDGCIEIPQLGVVRSLNVHVSGAIALWEYTRQQRA
The following text describes a protein:
Function:
Inhibitor of melanocortin receptor 4 (mc4r), a receptor involved in energy homeostasis. Plays a role during larval development in the control of energy homeostasis and body weight regulation by decreasing ligand-sensitivity of mc4r and mc4r-mediated generation of cAMP, leading to stimulate growth during larval development. Acts by stabilizing an inactive conformation of mc4r during embryonic development, when all the energy consumed is obtained from the yolk sac, possibly to speed the rapid maturation to the mobile free-feeding juvenile stage reached at 5 dpf.
Miscellaneous:
MISCELLANEOUS: Two paralogs of MRAP2 are present in zebrafish: mrap2a, which plays a role during larval development and mrap2b, which constitutes the ortholog of mammalian MRAP2.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MPRFQLSNSTSVPNHNYEWSYEYYDDEEPVSFEGLKAHRYSIVIGFWVGLAVFVIFMFFVLTLLTKTGAPHPEAAEPYEKRMRLTSCADGLGRQRETDGRTGLSRPLLEESRSLFHCYINEEEREGGRAATDAGALTHGRSGIGNSRGQVEEVGLVVQNMVLESRAEREAALLAHFNIPNFVNSELNSALGDEDLLLGDPPIIMEEARPRCTHHIID
The following text describes a protein:
Function:
Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine.
Subcellular Localization:
Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, cytosol.
Sequence:
MARCERLRGAALRDVVGRAQGVLFDCDGVLWNGERAVPGAPELLERLAQAGKATLFVSNNSRRARPELALRFARLGFGGLRSEQLFSSALCAARLLRQRLLGPPDTQGAVFVLGGEGLRAELRAAGLRLAGDPSEDPGAAPRVRAVLVGYDEHFSFAKLSEACAHLRDPDCLLVATDRDPWHPLSDGSRTPGTGSLAAAVETASGRQALVVGKPSPYMFECITEHFSVDPGRTLMVGDRLETDILFGHRCGMTTVLTLTGVSSLEEAQAYLAAGQHDLVPHYYVESIADLMEGLED
The following text describes a protein:
Function:
Negatively regulates the expression of its operon as well as expression of end (endonuclease 4).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target; MISCELLANEOUS: Part of an operon comprising at least mce2R and yrbE2A and probably extending to at least mce2A.
Sequence:
MALQPVTRRSVPEEVFEQIATDVLTGEMPPGEALPSERRLAELLGVSRPAVREALKRLSAAGLVEVRQGDVTTVRDFRRHAGLDLLPRLLFRNGELDISVVRSILEARLRNFPKVAELAAERNEPELAELLQDSLRALDTEEDPIVWQRHTLDFWDHVVDSAGSIVDRLMYNAFRAAYEPTLAALTTTMTAAAKRPSDYRKLADAICSGDPTGAKKAAQDLLELANTSLMAVLVSQASRQ
The following text describes a protein:
Function:
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
Sequence:
MVRMGNDNWPEIGEFVVCTVKNVTDFGAYVELEEFGGREGFIHISEIKAGWVKYVRDYVREGQKIVCKVLNVDPSRGHIDLSLKDVNEHQRRAKIQEWKNEQKAAKWLQFVAEETKTDENGLQALHEKLVEEFGSAYSAFEEAAIEGEKAFKGLKVNKKYLKSITKIAGENIKLPFVDIAGYVDLTCNHPNGIEVIKQALNAANSISDVDGKDVRLEVSYTGAPRYRIKVIAPDYKKAESVLKKSAQTAIDTISKLGGHGTFKRHIESAKA
The following text describes a protein:
Function:
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
Sequence:
MWVFGYGSLIWKVDFPYQEKRVGYIKGFSRRFWQGSTDHRGVPGKPGRVVTVVEDPEGCVWGVAYKLPEGREQEVKDYLDHREKGGYQVITVPFYPRPSSTSSPCETLLYIGSQAGPFPSSLQVEARNTKNRPCPSHAKRPRGQTQMVIRWRRGFSGFYFCFGICIDHLSHCNQMLTCCFLLKTLLKKKAFKKVLKLELMVVCYSSCVVSVCPE
The following text describes a protein:
Function:
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MTPAFHSWAEFFAMGNYAFYVWLAVAATLLSLLGLLMHTLWQHKQLLADIHRRQAREQRIRQAQLNQTSMHQVPLHQAPLHQAPLQQAPQHIANLQEKRP
The following text describes a protein:
Function:
Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The N-terminal and C-terminal disordered regions undergo liquid-liquid phase separation (LLPS) following homotetramerization and activation. Post-translational modifications, such as phosphorylation or lactylation affect the ability to undergo LLPS; The nuclear export signal acts as a transcriptional repression domain. The TADI and TADII motifs (residues 17 to 25 and 48 to 56) correspond both to 9aaTAD motifs which are transactivation domains present in a large number of yeast and animal transcription factors.
Sequence:
MMDEQGLDGMQILPGSQDSFSELWASVQTPSIATIAEEFDDHLGNLLQNGFDMNLFELPPEMVAKDSVTPPSSTVPVVTDYPGEYGFQLRFQKSGTAKSVTSTFSELLKKLYCQLAKTSPVEVLLSKEPPQGAVLRATAVYKKTEHVADVVRRCPHHQTEDTAEHRSHLIRLEGSQRALYFEDPHTKRQSVTVPYEPPQLGSETTAILLSFMCNSSCMGGMNRRQILTILTLETPDGLVLGRRCFEVRVCACPGRDRKTDEESSTKTPNGPKQTKKRKQAPSNSAPHTTTVMKSKSSSSAEEEDKEVFTVLVKGRERYEIIKKINEAFEGAAEKEKAKNKVAVKQELPVPSSGKRLVQRGERSDSD
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
Sequence:
MSSLEEMSMSATAAAERTVASLTERYSGRVQIHLHASSSLPSRLVSWSGDDTWDDLPVALVWTVDSLRLLRSYGVIGSFTGTLAQFAQQNVFLGLPVQLMAEEVVFLVRRACAVVIDESESYRASSAQERNEVDAKVQEDRASQQLGAWYERQQLRAQHSSHPIEQEPQWQELQNQPWHYTIPSRSTFPWYTPTAYTKLSKLQRVFAFPRSRHEMERCALFDHMLTNGMWCMNGLRFGGSLAVYPGDPLRYHSHYTAQLIGQNNCISIMSLVANGRLGTSVKKTHLLCCVDETDRTLDDELRTRDLHPSHIPTPLQCILQGNFDTAQRAENDPTSAVEQDPDAKPSTFAHFNVFSLAWAGFGT
The following text describes a protein:
Function:
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2 (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.
Sequence:
MNAELELLWPLSGLLLLLLLGTTAWLCVQCSRPGVKRNEKIYEQRNQQENEQSVASSQTYSLARPVRTGLQMDAASNKSFERKNKLLFSHLEGPESPRYQNFYKGSRRESDAAYVDPIPTDYYNWGCFQKPPEDNDSNSYENVLICKPSTPESGTEESEDYQNSVSILQWRESKRTMGARTSPSGSPDEEPDYVNGDVATTEKI
The following text describes a protein:
Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Sequence:
MDIDAEREKITKEIKELERILDPSSSSINVEVSESSLDSDSDADSLPDEDSDTAGPLISEEDRAGEASNDEDDPKEKALPEDPETCLQLNMVYQEVIQEKLAEVSLLLAQNREQQEEVMWDLAGSKGPKVKDGKSLPPNLYIGHFMKPYFKDRVTGVGPPANEDTREKAAQGIKAFEELLVTKWKSWEKTLLRKSVVSDRLQRLLQPKLLNQLPEEALLGSRLDSHDWEKISNVNFEGGRSAEEIRKFWQNSEHPSINKQEWSGQEVDQLKAIAAKHGHLEWQKIAEELGTSRSAFQCLQKYQQHNKALKRKEWTEQEDRMLTQLVQEMRVGSHIPYRRIVYYMEGRDSMQLIYRWTKSLDPSLKKGFWAPEEDAKLLQAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRLHFSLKKGRWNSKEEEKLMELIEKYGVGHWAKIASELPHRSGSQCLSKWKVMVRKKQSRGRRRRRPPRSVRWSSSSEDSSSGDRSRRGSSSSSSSSSSSESSEDSEPGPEEAQEGGQALPSAQHAVPDMDLWVPARQSTSELWGRGAGGWPGCSAASPSPPKGSSAAQGGHREACTTEEAGQAQAPTRAHSTSLTGSEYTRSVDTHPESSEGPADESGKRLLKVPLETVLQVLKTNTATRCRTLKEKLRQPHLLCSPLGECPSGSGVSGPRVRQLWHGSARSRQRRRGPTLQRRLLERQLLMAVSSWVGDVVLPCTSRRPTVVQTQADRIRKQLQEAHLASTPAFTLFLQLFQIDTAGCMEVVRERKAQPPTLLQAGTRDPLTRPLQVLSSARNTPGCLFQKAPVREVAKKSTIHREREGLQAPRNESTPQAPPPAPCGPRPKPKTVSELLREKRLREARARTAAKGPVVVPPPLLGSSPVTLQLRLPLVPQGPPASGPAVSNAALCGPGAPATASASTPGSWASAKDERPYTLQALALAVKAPAAPVASRAPVLGPGQVPGGCPLSSFGQSQAPATSRKQGLPEAPPFLPAAPSPTQLPIQPLSLMPALGTCRTGPHVAVSSPLPVTWVITAQGLLPVPMPAVVGLPQPRGTPDPKGLSVTLPPSVTETQAGQGPRLPGLSHPWQPPANRDTESDPPSKLDFSTFPTSPRSQSPAEVDSNVAHAPGGLSSPEEAQVAGETTAPRTSSQATLRADHPEAEPPQSSQLPSQGGTGPGGTPGPPSEPGEPRGPLGLERLPASQPGPEKGALGLERLPASQPGPEKGALGLERLPASQPGPEKGALGLSLLSQESEAAVREWLRGQRGVCVPALGRRLAYQPPTLCSLRTLSGLLLQKKALERRAASLVPGGVAGALHASRGLVHRRLQDSPAYLLLKARFLAAFTLPALLATLPPDGVPTTLSTTTRADSESENDSLGELELADGGRQLGSSVSSPQAEPAATASVEGTADSDKGCAPCCLDSLDDLDVLRTRHARHARKRRRLV
The following text describes a protein:
Function:
Probable transcription factor. Required for MC motor neuron differentiation and function, including role in modulating pharyngeal pumping. Regulates gene expression of FMRFamide-like neuropeptide flp-2 in MC motor neurons. May act downstream of transcription factor pha-4.
Subcellular Localization:
Nucleus.
Sequence:
MAFNIESLLEKKSNPVEEGNDFEEENDSEKNGEEDEEEEEKNVIDGWTNMATSQLAMFAIANDLRTPTLVELQMLLGVSARKHDYKRSRKSVCERKPRQAYSARQLDRLETEFQTDKYLSVNKRIQLSQTLNLTETQIKTWFQNRRTKWKKQLTSSIRQMVKDAPTSTSVGVPFQSLLTPPTPPTTLACHVNSLFACEQ
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MLRVSPSPAAVAAANQLSAAGATPAPVRVAAPRGGVSPSAAAACRATGKGKEVLSGVVFQPFEEIKGELALVPQTPDKSLARHKYADDCEAALNEQINVEYNASYAYHSLFAYFDRDNVALKGFAKFFKESSDEEREHAEKLMEYQNKRGGRVRLQSIVTPLTEFDHPEKGDALYAMELALALEKLVNEKLHNLHGVATRCNDPQLTDFIESEFLEEQVEAINKISKYVAQLRRVGKGHGVWHFDQMLLEEEA
The following text describes a protein:
Function:
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MAAAAVARRVVLVLVLAAASLAAAPRGAAARSLGGREGPGEVDADAAVDLNATNFDAFLKASLEPWAVVEFFAHWCPACRNYKPHYEKVAKLFNGRDAAHPGLILMARVDCASKVNIDLCNRFSVDHYPFLLWGPPTKFASAKWDPKQENNEIKLIDDGRTAERLLKWINNQMKSSFSLEDKKYENENMLPKNASDPEQIVQAIYDVEEATAQALQIILERKTIKPKNRDSLIRFLQILVARHPSKRCRRGSAELLINFDDHWSSNLSLSSQEGSKLLESVAEENHWICGKEVPRGYWLFCRGSKSETRGFSCGLWVLMHSLTVRIGDGESQSTFTSICDFIHNFFICEECRKHFYEMCSSVSAPFRTARELSLWLWSTHNKVNMRLMKEEKDMGTGDPLFPKVTWPPNQLCPSCYRSSKVTDGAVDWNEDAVYQFLVNYYGKKLVSSYKETYMESLQQQEKKIVSEDSSISNAASVPIGAALGVAIASCTFGALACFWRAQQKNRKQRKNWN
The following text describes a protein:
Function:
Catalyzes the deamination of dCTP to dUTP.
Sequence:
MTIKSDKWIRRMAQEHGMIEPFVERQVRGADDSRVISYGVSSYGYDVRCAAEFKVFTNIHSAVVDPKNFDEKSFVDINSDVCIIPPNSFALARTVEYFRIPRDVLTICLGKSTYARCGIIVNVTPLEPEWEGHVTLEFSNTTNLPAKIYANEGVAQMLFLQSDEACEVSYKDRGGKYQGQRGVTLPKA
The following text describes a protein:
Function:
Regulates programmed cell death; necessary for normal brain development. Participates with pro-caspase-9 (Apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. This activation requires ATP (By similarity).
Miscellaneous:
MISCELLANEOUS: Physiological concentrations of calcium ions negatively affect the assembly of apoptosome by inhibiting nucleotide exchange in the monomeric form.
Subcellular Localization:
Cytoplasm.
Domain:
The CARD domain mediates interaction with APIP; The monomeric form is autoinhibited in a closed conformation through a bound ADP at the nucleotide binding site. Exchange of ADP for ATP and binding of cytochrome c trigger a large conformational change where the first WD repeat region swings out, allowing the NB-ARC domain to rotate and expose the contact areas for oligomerization (By similarity).
Sequence:
MDAKARNCLLQHKEALEKDIKTSYIMDHMISNGVLTVVEEEKVKSQATQYQRAAALIKMILNKDNYAYISFYNALLHEGYKDLAGLLHSGLPLVSSSSGKDTDGGNTSFVRTVLCEGGVPQRPVIFVTRKKLVSAIQQKLWKLNGEPGWVTIYGMAGCGKSVLAAEAVRDHALLEGCFSGGVHWVSIGKQDKSGLLMKLQNLCTRLGQEESFSQRLPLNIEEAKDRLRVLMLRKHPRSLLILDDVWDPWVLKAFDNQCQILLTTRDKSVTDSVMGPKYVIPVESGLGKEKGLEILSLFVNMKKEDLPVEAHSIIKECKGSPLVVSLVGALLRDFPNRWAYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCVLWDLETEEVEDILQEFVNKSLLFCNRNGKSFCYYLHDLQVDFLTEKNRSQLQDLHRKMVTQFQRYHQPHTLSPGQEDCMYWYNFLAYHMASAGMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVCENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDTGRLYLEWINKKTIKNLSRLVVRPHTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSVDKKVKIWDSGTGKLVHTYEEHSEQVNCCHFTNKSNHLLLATGSNDSFLKLWDLNQKECRNTMFGHTNSVTHCRFSPDDELLASCSADGTLKLWDVRSANEKKSINVKRFFLSSEDPPEDVEVIVKCCSWSADGDRIIVAAKNKVLLLDIHTSGLLTEIHTGHHSTIQYCDFSPYDHLAVIALSQYCVELWNIDSRVKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWETRKVCKNSAIVLKQEIDVVFQENEMMVLAVDNIRGLQLIAGKTGQIDYLPEAQVSCCCLSPHLEYVAFGDEEGAIKIIELPNNRVFSSGIGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTEEYVFLQAHQETVKDFRLLRDSRLLSWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFELPSPLHELKGHNSCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHLCAPISIEEGTATHGGWVTDVCFSPDRKMLVSAGGYLKWWNVVTGESSQTFYTNGTNLKKIHVSPDFRTYVTVDNLGILYILQVLE