lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
Subcellular Localization:
Cytoplasm. Nucleus, PML body.
Sequence:
MYDKVEFFCVYTHLGHPVIQADIVLTGFWCDISALGFHVGSIDKMATKNAVAGKIESNMASPERMATEKGREAQNQQGVEDADTSTTAKNLALLKAHSLDVKFDVGEEYDIIETIGTGAYGVVSSARRRDNGQQVAIKKISNAFEVVTNAKRTLRELKILKHFKHDNIIAIKDILQPNLPHSAFKSVYVVLDLMESDLHQIIHSTQTLTPEHTRYFLYQLLRGLKYVHSANVIHRDLKPSNLLVNENCELKIGDFGMARGLSSHPEESYSFMTEYVATRWYRAPELLLSLNHYSLAIDLWSVGCIFAEMLGRKQLFPGKHYVHQLQLILSVLGTPPEGLISAIRAERVRSYVQSLPSRTAVPLSKLYPQAEPDALDLLGAMLRFDPRQRIGVTEALEHPYLAKYHDPDDEPICVPAFDFEFDKIAMSKEQIKDAILMEIQDFHKKKQSCRQKLQFKPLPRGNKGAAAQSNNQSNAPTADNLTESSLLPMVPRAQQIQQQQNHPAEANQAFADQIKAFDKSAALLDVTRTCVTHNLSLLSKTESGPVDVDMPSANSDSGQPETIDLTTPVSSQGASSEAMRDREVHEYLMNTQAQSAAQAPTTAPPRRTAPIPASAHSLSLSVAQAHSLSQSLSQSLGKNSRSSQPAAEGTRKEGAISEDTKNALKAVLLKSAIRQKARSDGGASAIGIDCGAGGGASSSLSSVLESRRSVTAQERQREREEKRKKRQERAREREKKMKEKERREGKQGDSLGGVLLSDNDKSLLQRWTRMMDSRCDKSQTPNNDGCKNKDCNESSHTGAVTEITAETMNNKTDEARTFQAHNQLISQVNPNQHGLFQSPSAQPPSLPFSMNQQTPSADLVTVNAGIDLMAMAGGFVKNALKPHPESGVQSRFGCLGNWSGQQLATRPPHQPNRTTQPAPSSFLQPQTKADPQPQLLPLESFLSRAATLNAQETNGNMGIGGQNNLNTMTGNSGQIEKLCSTLGGKPTSETRNPLCGTVGVSSQPHPSLVFTDTGQQGAPTAPDIHTVTLQLSKSQVEDILPPVFSVTPKGSGAGYGVGFDLDDLLNQSLTDLQNCDRDSYDSAPLSASLLSDWSEVHRMTPADLESLQQELQLGSPMILSDGIAPDS
The following text describes a protein:
Function:
Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein.
Sequence:
MDECLPNSCLLGVHLVISTHSGPQIVYHYPPSNTAFLTNNPTKHQHLYGNHANLNKNTSTNKEEKLFNSGSTKTASQIALNESAKSYNTAITPSMTNTNTNNVTLPPTRSHANTVGSQSSIPAATNGVGYRKTDIEDTSRTFQYQETESETSSSGLSDSELSTDYLDISSDSFSISSSLSSSSLSSSPSSSSSSSPPQDGLSRTNSSFQSTDSMSPTSPQMIMENDSISVAESYLDSGTNNKSRAASKRSQNFFHKLSTKKSTDSKTHSPVRKLKSKPSQSTKKGNKLLKNTSNETDGNAFTGSCSISSKKSLSSTGEHNQELRNSSLNDTPGQSPHHYHHRYHHYHKNAATSQRNSHTQYDVEEEDMEVSAMLQDGKISMNEIFFEEENFQDINKILEFDNDFVAEFCSPEREMCNTRFEFTVDNFCFLGLPIHVDSQGRWRKSKHKNKTRSKRSSSTTTNISRKKSIASKISSLSENTLKKVNSGEADTVYDSNIGHEASTDTPNLRINTDVSGNEFEREKEDLGKNMNMFHVCFVMNPHLIEYNKRIDDMYQFVVTRLSLLLRYVQSKTSYISSECHIILKEKERVLKHSKTYQSIRGAGNKGKYLYQRILAKSSLARALTECVDKIQRNEIACLEINDDKVISLQIPIQNEFEKMPNFKLQPVLRGSYLTSILNMKFLEKSSLRIESQNRQNDQAQFSDTNNNIYRFGNNINSTGHCGAANVDDGDDNESNYYCDDNDDLLNYALLLLDEPNNIISSLETFSYQDDIGTIILKHLVRNIQPNIPLRSYRYLITDLLDNPSSLDDLTTETNSLESSILRSCALHLMYWRHARIVIPLSSKYTYIVSPLAPIQGYTIDDYKSTSQNDGNVKKMDDRENNKSGSDRVPLIYQNSMLFRSKFPSLPSLPIFLSLLSTDKPQAYSNIIPSREHKPVYLNALAWLIQYGYVTQLLTFINIRVDKHIKMAVDEDLEKEGFRKTNTARRPSMDYKKTDKKLDDEDGQSRDANASEACSGKNEGMQSNDNNKDVDEKDNENDSRVDDRDDNEIAIADEEEILHFEYDDPEMQHDYTIILEPERATAIEKRWLYRCIYGQPSDIQILFNKLLKYFNGKVPMELVIIKEEISRHDLKKLLNALDKYLIEIHHW
The following text describes a protein:
Function:
Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
Sequence:
MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPTAVPVQQSVITAEIERWPETALTRELARHPAFVNRDVFPIIADRLTQKQLFDKLGLATAPWQLLTSTDEWSGIFDRLGELAIIKRRVGGYDGRGQWRLRADETGQLPDDCYGECIVERGIHFSGEVSLVGARAHDGSTVFYPLTHNLHQDGILRTSVAFPQANAEQQEQAESMLSAIMQALNYVGVMAMECFITPEGLLINELAPRVHNSGHWTQNGASISQFELHLRAITGLPLPAPVINAPSVMINLIGSELNYDWLKLPLVHLHWYDKAVRPGRKVGHLNLTDSDTSRLSATLEALSPLLPGEYASGIIWAQSKLK
The following text describes a protein:
Function:
Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
Subcellular Localization:
Nucleus. Mitochondrion.
Sequence:
ILCGGLNNRYCVLDVEERPGQTTLTVSCSRSLSPTETCLLRDGWEMTPVCRGDVVHLEGQRDGASWLVDREKGFLVLQPDSLISGTSISSSIRCMRRAVLGEMFKSFDGSSKQMLNGTMVHDVFQKAATAKDFSSVTLSRLADQALHSPQYLPDMYRLGVSQEEMKQELHDYMPSLEHWAKEYLSPSSPKAVRLSIRAPGQCQDAAALLTITELVDIEENVWSPRFGLKGKIDVTARVRIHRPRNGQHHGSQEERTIPLELKTGRESNSIEHRSQVILYTLMSLERYSPDAGFLLYLKTGNLHPVVASHMDRRELLKLRNTLVHHLHNCVERRGEKSRLAPLPDILSNRQTCQYCPQSRNCALYQRALDGTSAGVSEGVAGDLLQQETGHLTPPHLRYFSHWVLLCCLEAATMETKNSQKNIWLQSPEESEKNGSCVGNLAISGPVTAQAEGAFLHRFQRSRPEPRAGSHSSGLASGDRIVVGDQEGRFVGLATGHLREVNRTSVSCTLDRDLSKFPGLLFRLDGHEGAVGLSTHLTNLSRLMESSQGRSTCPFSALLSVFLDNVGRVSDRLRELVVDLRPPEFISSLSSVLPKEAKDAVANILKGWYPAPPHCRHGGRRPPAHLVHVGGAGLNKPQKQAMKKVLLSKDYTLIVGMPGTGKTTTICTLVRILHACGFSVLLTSYTHSAVDNILLKLKRFRVGFLRLGQGQKVHPDILPYTEESARKKGVHTLSELEQLYNKELVVGTTCLGIRHPLFTRRRFDFCIVDEASQISQPVCVGPLFYARRFVLVGDHQQLPPIVQNQEARSLGMDESLFKRLELHRDAVVQLNVQYRMNRQIMSLSNSLMYEGRLECGSERTATSLITLPLLPSVLPELGSLAWIQATLLPSNPVCFLDCSAVPALETVEQGGISNHTEAALIHKLLLLLIKAGCKPGDIGVIAPYRQQLRTISGLLQASAFTGVEVNTVDRYQGRDKSLILLSFVRSTAEEGPLGELLKDWRRLNVAITRAKSKLLMLGSATTLRRYAPVEKLLNHLQRENLISF
The following text describes a protein:
Function:
Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements.
Subcellular Localization:
Nucleus.
Sequence:
MALSEPILPSFSTFASPCRERGLQERWPRTEPEAGGTDDDLNSVLDFILSMGLDGLGTESAPEPPPPPPPPPPAFYYPDPGAPPPYGAPAGGLVSELLRPELDVPPGPALHGRFLLAPPGRLVKAEPPEADGGGGGYGCPPGLARGPRGLKREGAPGPAAACMRGPGGRPPPPADTPPLSPDGPARLPAPGPRAPFPPPFGGPGFGAPGPSLHYAPSAPAAFGLFDDAAAAAAALGLAPPAARGLLTPPASPLELLEAKPKRGRRSWPRKRTATHTCSYAGCGKTYTKSSHLKAHLRTHTGEKPYHCNWEGCGWKFARSDELTRHYRKHTGHRPFQCHLCDRAFSRSDHLALHMKRHM
The following text describes a protein:
Function:
Catalytic subunit of two functionally distinct, structure-specific, heterodimeric DNA endonucleases MUS81-EME1 and MUS81-EME2 that are involved in the maintenance of genome stability. Both endonucleases have essentially the same substrate specificity though MUS81-EME2 is more active than its MUS81-EME1 counterpart. Both cleave 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs. MUS81-EME2 which is active during the replication of DNA is more specifically involved in replication fork processing. Replication forks frequently encounter obstacles to their passage, including DNA base lesions, DNA interstrand cross-links, difficult-to-replicate sequences, transcription bubbles, or tightly bound proteins. One mechanism for the restart of a stalled replication fork involves nucleolytic cleavage mediated by the MUS81-EME2 endonuclease. By acting upon the stalled fork, MUS81-EME2 generates a DNA double-strand break (DSB) that can be repaired by homologous recombination, leading to the restoration of an active fork. MUS81-EME2 could also function in telomere maintenance. MUS81-EME1, on the other hand, is active later in the cell cycle and functions in the resolution of mitotic recombination intermediates including the Holliday junctions, the four-way DNA intermediates that form during homologous recombination.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPTDQVCLGRKRPLPSCPNPLFLQWLTELRDSAKEKGLKTHFVYQKAINSLKKYPLPLKNGKEAKILQNFGDGICKILDERLQKHYRENGSDAAVHLASSKQMEESQKEPSGNFSEHTKLTQKEVRKEKGAKKKREYVPQKRSGGYAVLLTLYRHMQMPGSKGFMFRNELQTEAQPLCEKSFTVPDLGSKYTAWSSVSTLIQKELVVKTHNPARYSLTDQGLSLAEKLDSEETGTRHEDVDSQDGQNVVDLTLEEEDEDEEKESWSSERPAVALPVNQARGLMSESDPMGKSQTSETGRTAMGWHLSPGSYDIVLCVDLCETTGGSSVRKQELVKELQRNSVTFDVRKLNVGDFLWVARERVTPVPGQLRPPVGKELVLDYIIERKRMDDLCGSIIDGRFREQKFRLKRCGLRKPIYLVEECGSAAAHLSIPESTLQQAIVNTQVVDGFFVKRVQDAKESAAYLTIMTRYLQKLYQNCTLLCRSRELEGDGEAESEKMVANLSCSLMAFTEFNYGAIKNKCQTVREVFARQLMQISGVSGDKAAAVLKHYSTVSSLLQAYDKCSSETEKEKLLSSVKYGKLKRNLGPALSRTIYQLYCTRGPLS
The following text describes a protein:
Function:
RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly.
Subcellular Localization:
Nucleus.
Sequence:
MDPKTFGDRVAKGRPQELEDKLKKKKERDVVADDTVSARRSKRRRLREESVLTDTDDVVYQPKTKETRAAYEALLSVIQQQLGGLPLSIASGASDEILSLLKNDAVKNPEKKVEINKLLSTEDDQIDQVFDQLVSIGKLITDFQEGGDSVGGHANEDEGLGNAFGVAVEFEGSEEDDDDGELDMVEEEEDEEDEEPQKTGGMQVDAGINEVDANEGTSLNVQDIGAYWLQKKISQAYEQKMDSQKCHVLAEELLKILAEGDDRGVEDKLLMHLQYEKFSLVKFLLRNRLKVVWCTRLARAEDQEERNRIEEEMRGLGLEVAAIVEQLHATRATAKEREENLQKSINEEARRLRDETVGDGGRGRRDVADRDLESGWLKGQRQMLDLESLSFDQGGLLMANKKCDLPPGSYRTHGKGYEEVHLPAVSKKVDVSEKLVKIAEMPDWAQPAFKGMQQLNSVQSKVYETALFKEDNILLCAPTGAGKTNVAMLTILHQIELNRNDDGTFNHGNYKVVYVAPMKALVAEVVSNLSNRLKDYGVTVRELSGDQSLSGKEIEETQIIVTTPEKWDIITRKSGDRAYTQLVRLLIIDEIHLIHDNRGPVLESIVARTLRQIETTKENIRLVGLSATLPNYEDVALFLRVDLKKGLFKFDKSYRPVPLRQQYIGISVRKPLQRFQLMNDLCYQKVVAGTGMQQVLIFVHSRKETAKTAHAIVETAMANDKLSKFLKEDSASREVLQSQIGLIKNGELRKLLPYGFAIHHAGLTRGDREIVEALFGGGHVQVLVSTATLAWGVNLPAHTVIIKGTQVYNPEKGAWMELSPLDVMQMLGRAGRPQYDRSGEGIIITGHSELQYYLSLMNEQLPIESQFISKLADQLNAEIVLGTVQNAKEACHWLGYTYLYIRMVRNPTLYGLAPDALVKDVVLEERRADLIHSAATLLDKNNLVKYDRKSGYFQVTDLGRIASYYYISHVTIATYNEHLTPTMGDIDLYRLFSLSEEFKYVSVRQDEKMELAKLLDRVPVPIKETLEESSAKINVLLQAYISQLKLEGLSLTSDMVYITQSAGRLVRALYEILLKRGWAQLAEKALNLSKMVGKRMWSVQTPLRQFHGIPNEILMKLEKKDLVWERYYDLSSQELGELIRSPKMGRPLHKFIHQFPKLVLAAQVQPITRTVLRVELTITPDFQWDEKIHKYVEPFWITVEDNDCEKILHRECFLLKKQYISEDHTLTFTVPIFEPLPPQYFVRVVSDKWLGSQTVLPVSFRHLVLPEKHPPPTELLDLQPLPVTALRNPNYESLYQDFKHFNPVQTQVFTVLYKTYDNVLVAAPTGSGKTICAEFAILKNHQEVLLRQEDDATMRVVYIAPLEAIAKEQFRIWERKFGKGLGLRVVELTGETALDLKLLEKSQIIISTPEKWDALSRRWKQRKYVQQVSLFIVDELHLIGEGQGGTVLEVIVSRMRYISSQGDNKIRIVALSTSLANAKDLGEWIGASSHGLFNFSPGVRPVPLEIHIQGVDISSFEARMQAMTKPTYTAIVQHAKNKKPAIVFVPTRTHVRLTAVDLMAYSQMDNPQSPDFLLGKLEELEPFVKKISEETLKETLRHGVGYLHEALCTHLVVVMGTQYYDGRENSHADYAVSDLLQMMGRASRPLLDNAGKCVIFCHAPRKEYYKKFLYEAFPVESHLQHFLDNNFNAEAVAGVIENKQDAVDYLTWTFMYRRLPQNPNYYNLQGVSHRHLSDHLSELVENTLSDLEASKCIEIEDEMNLSALNLGMIASYYYISYTPIERFSSLLSSKTKMKGLLEILTSASEYDMIPIRPGEEDRVRRLINHQRFSFENPNCTDPHVKANALLQAHFSRQDIVTNLEIDQREVLLSATRLLQAMVDVISSNGWLNLALLAMEASQMVTQGMWERDSMLLQLPHFTKELAKRCQENNIETVFDLVEMEAEERLELLSISDTELLDIAKFCNRFPNIDLTYEVVGSEDVTPGKEVTLQVTLERDMEGRTEVGAVDAPRYPKTKEEGWWLVVGDTKTNQLVAIKRVSLQKKAKVKLDFQVPSEAGEKPYTLYFMCDSYMGCDQEYAFSVDVKESMEE
The following text describes a protein:
Function:
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
Subcellular Localization:
Secreted.
Sequence:
MRIFSFLFLLLLGILTGQGLVSGTDNGKTTDVTWDKYSLSVKGQRLFVFSGEFHYQRLPVPELWLDVFQKLRANGFNAISVYFFWSFHSASEGEFDFENGAHDIQRLFDYAKEAGLYVIARAGPYCNAETSAGGFALWAANGQMGNERTSDEAYYEKWRPWILEVGKIIAKNQITNGGPVILNQHENELVETTYDPNHTLVVYMKQIAQVFEEAGIVVPSSHNEKGMRGVSWSTDYHNVGGAVNIYGLDSYPGGLSCTNPNSGFNLVRTYHQWFQNYSFTQPSYLPEFEGGWFQPWGGSFYDTCATELSPEFPDVYYKNNIGSRVTLHSIYMTYGGTNWGHSAAPVVYTSYDYAAPLRETREIRDKLKQTKLIGLFTRVSKDLLKTYMEGNGTGYTSDSSIYTWSLRNPDTNAGFYVLAHSTSSTRDVTTFTLNVTTSAGAISIPDIELNGRQSKIIVTDYNFGTNSTLLFSSAEVLTYANLDVNVLVFYLNVGQKGTFVFKDEPKLAFQTYGNSNLTTSESSYGTQYSYTQGKGVTAVKFSNGVLAYFLDKESAWNFFAPPTTSSPQVAPNEHILVQGPYLVRGASVNHGTVEITGDNANTTSIEVYTGNSQVKKIKWNGKTIETRKTAYGSLIGTAPGAEDVKIQLPSLDSWKAQDTLPEIQPDYDDSKWTVCNKTTSVNAIAPLSLPVLYSGDYGYHAGTKVYRGRFDGRNVTGANVTVQNGAAAGWAAWVNGQYAGGSAGSPNLAATSAVLTFNSSSLKDQDNVLTVVTDYTGHDQNSVRPKGTQNPRGILGATLIGGGNFTSWRIQGNAGGEKNIDPVRGPMNEGGLYGERMGWHLPGYKVPKSASKSSPLDGVSGAEGRFYTTTFKLKLDKDLDVPIGLQLGAPEGTKAVVQVFMNGYQFGHYLPHTGPQSLFPFPPGVINNRGENTLAISMWALTDAGAKLDKVELVAYGKYRSGFDFNQDWGYLQPGWKDRSQYA
The following text describes a protein:
Function:
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions.
Subcellular Localization:
Cell membrane. Cytoplasm, cytosol.
Sequence:
MATRKAGSRLETEIERCRSESQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEHPLRQGASPRGPRPQLTEVRKHLTAALDRGNLKSEFLQESNLIMAKLNYVEGDYKEALNIYARVGLDDLPLTAVPPYRLRMIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAGDIALLYLQEIERVIFTNIQNRSPKPGPAPHDQELGFFLETGLQRAHVLYFKNGNLTRGVGRFREILRAVETRTTQNLRMTIARQLAEILLRGMCEQSYWNPLEDPPCQSPLDDPLRKGANTKTYTLTRKARIYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLISLQSASVVYDLLTIALGRRGQYEMLSESARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDAGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLESLCRGPDEALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGSIHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQVAELRGNVDEARRWYEEALSISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPFTIIPRVL
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Late endosome membrane.
Sequence:
MSQKFPAFYPITQVCVVADPQKCPPSYDLLMRSKDKEADCDLWRESGMFKRYTRYLCFTRSFNIDNLQDNMVLVALQILNEKDFPPTGFTTIDKTLDSEEKAFRKKQLCVKMASRNSVSTAITDIVLLTKVKRPPEEYTLLGDINGILVCYKTGRVPPETQSFIHAANSIVANTTAAAASTAASTAAISNKITLRFVLFLDFLSLFCLL
The following text describes a protein:
Function:
Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches.
Subcellular Localization:
Cytoplasm. Note=Septum. Localizes to cell tips during interphase and the septum in mitotic cells.
Sequence:
MLRNGAQNGNINSESHESFGKAAKGFRIFSSFSSSQKLFQRRSSGSITHSPTALSSTTSLNENDGNHFRPASSLSFSPSSLSRKDSGPGDGLEVNKKNNFYRRSSSTDDFGISHARSRKEIQSLGRPHTRQSFSVSDVSNGSSYPNIRKNSVHVNAPMPSFPEGSTAVLLKHHSGSKSASAISNIAPSHSNSTSSRRPYIHPAFLSQVAVEFRKRLNIGDRVKDGLLYKDAFLGSEAVDVLMHIVRTTDRNLALLLGRALDSQKMFHDVTYSHRLRDSLKEVYQYRRIISPPPGLSSMDSNGSSIENNFLYTKRRANTSDSFDSVLSDSSTTPTISSSVQVNSLAFITSSLSAITKEPEAPETEYNPHGVFTLLTECYSSTCSRNRLCYSISCPRRLEQQARLHLKVQPVLSGGSTSITDKQEEDHRLWSENVPKQVVDQIDVREWKRQEIIFEVIYTERDFVRDLEYIRDFWIKPLSTSNVIPENNRQQFIRCVFHNIMQIHAVNSRLSNALNRTQTLQPVVNTIGDLFLDYVPKFEPFIKYGANQAIAKFEFEREKSTNRNFANYVHEVERLRESRKLELNGYLTKPTTRLARYPLLLSGVLKYTDKDNPDTENIPRVIEMIREFLTKLNYETGKTENRLSLLQLNEQLSCSPADRAKLTLFDPSRLLIFKGVVKLKASSYSNGDTENDIHMFLLDNFLLLCKIKIQMKRRVHKLHLRPLPLELLSISYIEDSPSRGSLPRRPSSALLTNPISITKSNPPPVKAYGLQLVFIGARGFSISLYLNTLIARDQWKQHIEKQQDIIRKRHLVFESRGICCQSWFTGNKLLCAVAYDAGRKLLFGTYKGLYISSRKSNNGSCLEPIFKLQLPNISQLDVIEEHNVLLLLAEKILYELPLDALDSVEQINSKSLRRVTGHVSFVKTGFCMQRILVCAVKSTVLNTTLRIYEADRALKNKKTQSLKKPFGNQATLKIFTEVQMPMEALSVHFLKTKLCVGSFKGFDIISLENAVFQSLLNPADTSFRFLEKREDIRPIAMFRLRGEFLLCYSDFAFFVNTNGWKSRQSWMINWEGQPQGCALCYPYILAFEPDFIEIRNAETAELVQIIMGQNIKLLTDGRGLISEGGEILYSTEPIPFSSGENPIVHSLILPPANAAGPAL
The following text describes a protein:
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MKAQDWIIITCCLCGLGAMTGATEMEDKLMKKLFSAYNSKVRPARNPEERVVVRIGMILSSFVSLNMKDEEMNTIVMMNLEWNDYRLSWNPKDYGGVDVLRISSGKVWLPDIVLINNNDGVFGVALQVHVQAYSNGRVTWTPPALYKSSCGVKVTYFPFDWQNCTMVFRSYTYDSSEVDLQHALDKRGKEIKEIILDTGFSESGEWHIRHKVSRKNVREDLYEDITFYLIIERKPMFYVVNIVLPCILITIIAIFNFYLPPDAGEKMGLSINVLLTLTVFLLLLANKIPETSLGVPIIVNYLMITMILVTFSVILSVVVLNLHHRSPNTHQMPLWVRKIFIHMLPPYLGMLRPKVETPLFLEKPAKKENIQAINRVADEYFIRKPSNMNFLFPKPHRYQPDGQCTDLRKFIDGPSHYLTLPPELKTAVEAITYIAEQLQAEKDYEALKEDWQYVAMVADRLFLWIFVIFTTLGTLGIFTDASFNATPTDPFP
The following text describes a protein:
Function:
Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MFRAAAPGQLRRAASLLRFQSTLVIAEHANDSLAPITLNTITAATRLGGEVSCLVAGTKCDKVAQDLCKVAGIAKVLVAQHDVYKGLLPEELTPLILATQKQFNYTHICAGASAFGKNLLPRVAAKLEVAPISDIIAIKSPDTFVRTIYAGNALCTVKCDEKVKVFSVRGTSFDAAATSGGSASSEKASSTSPVEISEWLDQKLTKSDRPELTGAKVVVSGVGASRAAVDAGFVPNDMQVGQTGKIVAPELYIAVGISGAIQHLAGMKDSKTIVAINKDPEAPIFQVADYGIVADLFKVVPEMTEILKKK
The following text describes a protein:
Function:
Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MARPPPCWLWILGTLAGLSATPAPKRCPEKHYQVQGERCCQMCKPGTFLVKDCERHGEAAQCDPCIPGASFSPDHHARRHCESCRHCNSGLLIRNCTLTANAECDCPKGWKCRDKQCTECDPPSNPLLIPHPSPARGPHLQPTHLPYAKIKFQATLCPVTEMQETSTVRQVQTLADFRWLPAPALSTHWPPQRSLCSSDCIRIFVILSGMFLAFTMIGALFFHQQRKYRLNKEEYPVVPVEPCPYSCPREEEGGAIPIQEDYRKPEPASYC
The following text describes a protein:
Function:
Resident vacuolar enzyme that catalyzes the removal of amino acids from the N-terminus of peptides and proteins. Also acts as the major cargo protein of the cytoplasm-to-vacuole targeting (Cvt) pathway. The precursor form of aminopeptidase 1 (prApe1) assembles into dodecamers and the propeptide mediates the aggregation of dodecamers into higher multimers. The multimers are then recognized via the propeptide by their receptor ATG19, and ATG19 further interacts with ATG11, which tethers the APE1-ATG19 complex to the pre-autophagosomal structure (PAS). The cargo-receptor complex (also Cvt complex) is selectively enwrapped by a double-membrane structure termed the Cvt vesicle under vegetative growth conditions and by a similar but larger double-membrane structure termed the autophagosome under nitrogen starvation conditions. The Cvt vesicle or the autophagosome fuses with the vacuolar membrane and release its content in the vacuolar lumen. In the vacuole, prApe1 is processed into mature aminopeptidase 1 (mApe1).
Miscellaneous:
MISCELLANEOUS: Present with 5730 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole. Note=Transported to the vacuole by the cytosol-to-vacuole targeting (Cvt) pathway.
Sequence:
MEEQREILEQLKKTLQMLTVEPSKNNQIANEEKEKKENENSWCILEHNYEDIAQEFIDFIYKNPTTYHVVSFFAELLDKHNFKYLSEKSNWQDSIGEDGGKFYTIRNGTNLSAFILGKNWRAEKGVGVIGSHVDALTVKLKPVSFKDTAEGYGRIAVAPYGGTLNELWLDRDLGIGGRLLYKKKGTNEIKSALVDSTPLPVCRIPSLAPHFGKPAEGPFDKEDQTIPVIGFPTPDEEGNEPPTDDEKKSPLFGKHCIHLLRYVAKLAGVEVSELIQMDLDLFDVQKGTIGGIGKHFLFAPRLDDRLCSFAAMIALICYAKDVNTEESDLFSTVTLYDNEEIGSLTRQGAKGGLLESVVERSSSAFTKKPVDLHTVWANSIILSADVNHLYNPNFPEVYLKNHFPVPNVGITLSLDPNGHMATDVVGTALVEELARRNGDKVQYFQIKNNSRSGGTIGPSLASQTGARTIDLGIAQLSMHSIRAATGSKDVGLGVKFFNGFFKHWRSVYDEFGEL
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MIKGKRSFPKRQNNVRVLNSSRVEEFDISDHNQSIDSINELSAYEVLSLRKKTEDGIKSNLNEERVASSLTSRAEDNKPCRDFVKSDRNVLASDFLSKYGEETDEMNKTKKKQKKIMKKEIRKRTKRKRKSVNKRELSGSIKTWIPTHSGSSVFSSLFRNCDDSKEMXDSIVDCLSEGEEIEEIKIVNLSDSSHGSSFESDEINEDKNMVDEEENDEELIDERSTNSAVRENFVRCYGKEKDEDASDVVIDFEQKPFSTHCDSVQNGLDAIQWLIDPYDLTQFFKMVFQKKVFLVCHNNPNYYGNLFSTAKFIDILQTDYVEYGTNVNVAIYKNQQRSTLNGSGKVYPQAIQKSIKAGCSIQLTNPQSFCDNVWYYCDLLQEVFGCFVGANIYITPANTAGFAPHWDDIDAFLLQLEGRKHWKIYAPDSDDEMLPRLPSGNFTDNDVINRMLVFDDWLEQGDMLYIPRGYIHQGFADKDVHSLHLTVSVCRNVTYADLLERVIPPALSNFAEQNVNIRKSLPARYLDMTGVLECDYPLLKTGTMKLHRFLDSIFSNFCKYIKELSEPAVDMMAREFMRTALPPVLTKEEKDMTALCVAGSSLYGDKEHIFTKNTSIKLLRRHGQRLIYESEERCFIVHRMANSRVYEGRPEVLFDLDVELAEGFANLVNAYPRWCLVSDLKCNDAADNIRLAELLYSNGLLMAEFREAMK
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular Localization:
Midbody, Midbody ring. Cell projection. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MDDNEEKKLDENKISKVLSSIPEQYHKTSFQARRTALDYMRSSNRKELLNQIGDWLDEVNVETDNIVDVYFQGFNKSIHNYSRILEFMGTSHGNALLMSKEVEETNKLINFNGTGIERLWKRNLEYYYMIEILEKMEELKKVPDLLNKYIKGNHFVHAANILVNSISTLNERDLVNVNALMDLRQMLVEKKESFKDMLVEKLNDHIYLKTKSSLKAFEYDDENNLQSNFKKILLSNKNSNSNNSNNTFKSPLPPTTTSPFKPQFTGAFQTKASQEKAEKAAANLYNQERLSQSNQPEVLKLEEISKTSNSKEDLNIDPEQDGKLFMTLLVEALNVLEYLSPAVGLILGRISIELKTAITNSITLITNVYHSEGRVIPKMPGESSNSSNGSNGSNGGGNNSMNGSGGINGNGSTASSSSPTSSTSSNIGANGLSPSVLSKNSHIGSATFSNIDEYSAAFNFLTETFNRNDLLANQTHNIPLVDLLKMIFNKVNMVFKNHLQLSKIFNDAIRKSELKIRANKFDFKEETEGGGGDSDNDFEGTPKPTKLQKSKVEIADVYDASLVWEIIQKEIREMLRVHLQDTSSLLLSTKSRLNPDGTESNSGKSQRLFSFTNSIVTDNWNGSISPMVTTSPTSPNGTSGADAIDSNSGGPAVISIFKASQYNVTPIYPMIVKFTDHLDKTLRDRTGTPTTTKTTTTITTTTTNSYHNQNSKKGLLRLYIDDFVHRNFLQHIKNDYKDRFAHSIESTEAFKPLERYKLVFRLKETKPILNSTLQIFQFVIELFSDIVAMSHYVVEFGAIIQVSLLRYYEKCLSKFSQEIDPTLTNQLLNTDLYKYLLASLAVSSKKQDVAKFQDSREEEYEFKLESDLFNHPEKPVLKNQLILNIEKLTMLANMSHSLNWLADKIVQLLIVQEDQKEKYTQQQQQQQQQQQQVDSIKTPSKLNSGINSGGNSTASNKENNSTTTGSNNFIGTFNQMSAESIEALKTMEEPIKDIAQRFKDLSKRCLLALRIEYRIHCFYFLEGFKRAQYMCEEERTDPDSFIVELNKDLSASEEMMSIYLTSDKCNFLFSGIAKLIGKLLISKLVHVNSINDNGVAKLCKNVFTLQQNLSNIIVKREIFFDRIRQFYQALSAEDELLNYLLEKMSQPFFSLEEGKIIIDFLQRTKRISPNAILTLEAKYKNM
The following text describes a protein:
Function:
Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea it increases their affinity 2- to 3-fold. When bound to RseA it prevents proteolysis by DegS, which is probably relieved by lipopolysaccharide binding (LPS).
Subcellular Localization:
Periplasm.
Sequence:
MKQLWFAMSLVAASLFFSANASADPASGALLQQMNIASQSLNYELSFVSITKQGVESLRYRHARLDGRPLAQLLQLDGPRREVVQRGNEISYFEPGLEPFTLNGDYIVDSLPSLIYTDFKRLAPYYDFISVGRTRIADRLCEVIRVVARDGTRYSYIVWMDMDTKLPMRVDLLDRDGETLEQFRVIAFTVSQDIGSNMQALAKANLPPLLSVPGGEKTKFNWSPSWVPQGFSEVSSSRRPLPTMDNLPIESRLYSDGLFSFSVNVNRATQNSSDQMLRTGRRTVYSSVRDNAEITIVGELPPQTAKRIADSIKFRAVQ
The following text describes a protein:
Function:
Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with the membrane through an interaction with FtsX.
Sequence:
MIKFSNVSKAYHGATQPALQGLNFHLPVGSMTYLVGHSGAGKSTLLKLIMGMEKANAGQIWFNGHDITRLSKYEIPFLRRQIGMVHQDYRLLTDRTVVENVALPLIIAGMHPKDANTRAMASLDRVGLRNKAHYLPPQISGGEQQRVDIARAIVHKPQLLLADEPTGNLDDELSLGIFNLFEEFNRLGMTVLIATHDINLIQQKPKPCLVLEQGYLRY