lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cotranscribed with fur, it is essential for fur translation. The fur ribosomal binding site (RBS) is occluded by the 5'-mRNA secondary structure, which is opened by uof translation.
Sequence:
MIRIISRANSVTSSNEVNRLVTGQIPHD
The following text describes a protein:
Function:
Cell-surface associated glycoprotein that acts as a plasma membrane receptor-type protein which senses the presence of matrix. Binds to calmodulin in response to environmental conditions and initiates a signaling cascade that activates CEK1, thus promoting invasive filamentation. Involved in the maintenance of the cell wall.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell septum. Secreted, cell wall. Note=A part becomes cross-linked to the cell wall and thus links the cell wall to the plasma membrane and cytoplasm.
Domain:
The GxxxG glycophorin motif in the transmembrane domain is required for CEK1 activation and subsequent invasive filamentation on agar medium; The cytoplasmic C-terminal calmodulin-binding motif (residues 301 to 317) is important for CEK1 activation and subsequent invasive filamentation on agar medium.
Sequence:
MEKLSINNNNNNRRYQSRRFDGITIIRIVVLVFIVTVSTYFVNSYTCNQPHHNHSTRPSHYLPINGTHGLMNNDDSLHNKGAIGHYNTTVSLERRADENNSTTNGLFPSTSSSTFIFTPSSSSSSTFQQSRSSPQTTSTSSFVATTSSFQQETSQTSIPDTTTDFSFSSFSEAPTTSTTSSTSEFSSTPQETSNTVTSTSSTSTSSSSSPTSSPATTSASQHVTTFSSVDNGKTIVVTRTSVISSSPTASNSNNNKNNDNGGGLSHTNRIVVGVVVGVGGSILIGLLAVLFYLRKRNNRDYEGGWTFWRKNEKLGSDEFFNGELGVRDRNINQGSNF
The following text describes a protein:
Function:
Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSLLKERKPKKPHYIPRPPGKPFKYKCFQCPFTCNEKSHLFNHMKYGLCKNSITLVSEQDRIPKCPKSSSLDPKQTHQPEPTSKPATSKSLLNGLSSFDPKSQQGSAKEDAKENLEMQARGAHKGPQKPALQKEMAPEAILSTQPCLDSGVRHSAFVPVGEHRLRGPEDTEATEVLANSTTKASSFHAKSAFHTPGYPWKAGSPFLPPDFPHKISSTKGFGAISPYMHPAIPEYPHPFYAEHGLAAIYSPYLLTGNTPECETTLLSVYGTQDQRHFLSPAGPIPKHLNTSPSTYDHYRFFQQYHSNLPIPYGFYRPESAFPSYSLRLPSVTGITRDQSSRLLEDATLAYPASSPSELNLSSSHRKHTECEKGSPVPEAKDPSKDGQRDAEEAKMSPRAGSAATGSPGRPSPTNFTQTSQTFEGLCDLSNKAASSGTLERLQQAEQSPTAFKPVQRGSESPHSQPPANRTESPKSLQAMNGDPPAQTGSSNSFITEAPPSSPEDHSRIGPLNLSKKLETNPAATYGPMYASNAQADTLQDLPLNLSVKDLCNAWAPRPALPGPPQGAEPAATPKTETKGSEDRTSRVETPQDKAHSRTTPDVHTEDSSDEQKQTAAVALCQLAAYSPGNVRVADEEGTVQEPTRQDVPTLSATENLEAQCDLRPKGQKRTSQRDTGKSQQGTKKPKLNDPVPRVLTLRRRTRVS
The following text describes a protein:
Function:
Component of the cell wall.
Miscellaneous:
MISCELLANEOUS: The strains CLIB 410 and CLIB 630 haplotype Ha2, contain large deletions that remove most of the protein; MISCELLANEOUS: Present with 67000 wall-bound molecules/cell in log phase YPD medium.
Subcellular Localization:
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Identified as covalently-linked GPI-modified cell wall protein (GPI-CWP) as well as protein covalently linked via an alkali-sensitive bond not requiring the GPI-derived structure. Can also be double-anchored to the cell wall through both types of linkages. Incorporated into the birth scar of a daughter cell.
Sequence:
MKFSTALSVALFALAKMVIADSEEFGLVSIRSGSDLQYLSVYSDNGTLKLGSGSGSFEATITDDGKLKFDDDKYAVVNEDGSFKEGSESDAATGFSIKDGHLNYKSSSGFYAIKDGSSYIFSSKQSDDATGVAIRPTSKSGSVAADFSPSDSSSSSSASASSASASSSTKHSSSIESVETSTTVETSSASSPTASVISQITDGQIQAPNTVYEQTENAGAKAAVGMGAGALAVAAAYLL
The following text describes a protein:
Function:
Protein transport. Probably involved in vesicular traffic.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MATRRRMLLKVIILGDSGVGKTSLMNQYVNRKFSNQYKATIGADFLTKEVHFEDRLFTLQIWDTAGQERFQSLGVAFYRGADCCVLVHDVNVMKSFENLNNWREEFLIQASPSDPENFPFVVLGNKIDVDGGNSRVVSEKKAKAWCAAKGNIPYFETSAKEGFNVDAAFQCIAKNALKNEPEEEIYLPDTIDVAGGGRQQTSTGCEC
The following text describes a protein:
Function:
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Sequence:
MSKISIIAAVDRRMAIGFQNKLLFWLPNDLKRFKALTTGNTIIMGRKTFESLPKGALPNRRNVVLSTRPDTVCPGAEVFPSLEVALQSCKEDEHVYIIGGASVYQQALPLADELCLTEINDVAPEADAFFPEVSPAQWHEKSREAHPVDEKHLCPYAFVDYVKQ
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MQSKFWAKAIDEDSGDNVTESSESEVEEKKPIVSAQAERWAAIDSSSSEEEERVIKTYEGKRLHFYETTGNSLNENMYNNDFNLLLKDYENLYKFMIKESADCIPNFAIIYLDKLSKYVEKTFQNNVEKKNLSKNKAQTLNKLRAKIRKCSEFYQEKLNLYNENPDDFKDDRKKDMDDDEDDEDNEEDDEEEEEDEEEQEDQDDDNEDEKDQDDDEDGKGKKKLSSKTKSKKGKEKKEEKEDYDDDNDEEKEDEADDDNDDDDDDSDDWSYSEDDNYASDEEDDKTKNAMSKWGLKTSTKVEKKKTVKQKKVKKESTKKEEKANRVVEDSQSAKNKGYAELLSTKNLTEDVIRERVKLVIEKRGRKGLDKHEHINILSKLCEIAKTISTQSYIEVLEHLINLEFDVVSSVYTYMSFNIWNKVFKYVELILDILIQNENFYLVSINIAEEITEETTNEKEKIIKSCKTLISFLAKLDDELLKALLYIDVQTEEYRKRLGKTIHMIGLLKKGYNYVKCLKNMPDLAIHISSRILEHMYYKPEMLFKQIWTYLMNGKEMLSDSLNNSNNIASKEDGQGKKKKRIDNDLFDEKLINNDSINPPKIIEEYVYEIFEFGTKQQKVKALLQLSYNKSLYDEYLEAKELLNVANVHELAMNSDIQTQILYNRNLIQLGLCAFRHGKIYEAHCCLMEICSQNKHKELIAQGISNLKNQEKTLEQERAEKRRLLSYHMHISIELIECVNNICAMLLEVPNLAKNTYESKKDIISRQFRRFLDIYDKQIFNNPPENNKEIIILATKHLQKGNWKLCCEKIFSLSIWPKFPDKEKVQNILKEKIKQEAMRTYIFRYISIYESFSIDQLCVMFDLNQNVVHSILSKMMINQEIPAFWNESSKFILISKVNPTTLQNLALKLAENVNEVMEQNELALNMKNPKFMFMQERRTQMKEEKSNWTQKKGDQKYQKNYNQKKNAHYKKNYKDNNANKNYKKN
The following text describes a protein:
Function:
Degrades free oligosaccharides in the vacuole.
Sequence:
MCDSICHKPVYPILAEQTLRPVRPLPIRSIQEKRIYEFVGGQFSSDNLSSLLYAGRLNTQPHVQIKCWSPANGTRPTFNEACSQTFMPCQVGEKFGPSWSNHWLKLILTVPDEWMDLDDVELDFDVSCEALIYDDQGNPLQGFTGGQEFDRRHDFPLPKGNHARVSAIYYIELTGNGMFGIHGKDTRYYDLGVGSDPDPNRFFELAKVDIVLKRREAWDLMYDFITLQQCVEELPKDGILQNKALFITNEIMNTFRKSDLSSISRCRQLAQEVYGEAWSSSPSSFLSGDADKKNKDKNAVIWSLGHCHIDCVWLWSFDAAQQKVARSWTTQLALMERYPEYCFTASSAQQFKWIETLYPSLFQRIKQKVKEERFQPIGGLWVECDANMPSGESFVRQLLYGQRYLQSRFGFKSNIFFLPDSFGYNSQIPQLARQAGCDYFFTQKLCWNRTNTFPHCTMMWTGLDGTQIVFSQSSIPNYNSRCGVNDLLKGIRRNPDLAVQPTCLHLFGFGDGGGGASPEHLERLRRARALSDNGYAEMPRVTVGRSANDFFEHLLETTQQGERLATWSGEVYLEFHRGVYTSQAAMKKYNRTVELMLHDLEWLCTLAAIHSRQVMYKYPHDKLAEIWEPFMLSQFHDCLPGSSIRKVYEDMEKVYAQLSVKIKEMRDEAVAVLLDTASDKTFSDFILAAPNTLCIPRREILEMKEANMTPIAAPTLALQDLQDSRTLILLEDVEATGVLKCVSSPLAPAAMSTVSAVQAGSTFVLESIDMCVRVSDGRIRSIFDKIEGREILAYGQSAGFSLSQDYPPEFDNWEVEVYSLDTVEQLEFEFVTVTDTGPYRASLTATLSIGEATSLSVNIFMDALPLIPALTAGERPRTAIQFRTSIQWQESHRFLRWQVPTSIRSDLASYEMQFGHVTRPTTRNTTWEAAKFEVCGHRFADLSEPNYGLAILTQCKYGYSVEGGLMRLSLLKAGAYPDSKMDRGKHTIDFALYPHRGTLLDGNVVDVARVYNAKPVLEAMLITGPKSMSSFECPLRVVQDLTSLHSKVVLDTIKMAEPALIASNKCGQERSKTMLCRLYEAFGTRTKVTLECDLPVNRASITNLLEEEHVEESIDLFSEGRLRAILHFRPFEFKTIRIELR
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Sequence:
MSGGGGKDRIAVFPSRMAQTLMKTRLKGAQKGHSLLKKKADALNLRFRDILKKIVENKVLMGEVMKEAAFSLAEAKFTAGDFSHTVIQNVSQAQYRVRMKKENVVGVLLPVFDAYQDGPDAYDLTGLGKGGANIARLKKNYNKAIELLVELATLQTCFITLDEAIKVTNRRVNAIEHVIIPRIENTLTYIVTELDEMEREEFFRMKKIQANKKKLKEQEAAQRALEGPPKEEAGGTHSENQPPRNLLAVEEDNLPVLFN
The following text describes a protein:
Function:
Possesses beta-1,3-endoglucanase activity in vitro. Is thought to be an important plant defense-related product against fungal pathogens (Probable).
Subcellular Localization:
Vacuole.
Sequence:
MAISSSTSGTSSSFPSRTTVMLLLFFFAASVGITDAQVGVCYGMQGNNLPPVSEVIALYKKSNITRMRIYDPNRAVLEALRGSNIELILGVPNSDLQSLTNPSNAKSWVQKNVRGFWSSVLFRYIAVGNEISPVNRGTAWLAQFVLPAMRNIHDAIRSAGLQDQIKVSTAIDLTLVGNSYPPSAGAFRDDVRSYLDPIIGFLSSIRSPLLANIYPYFTYAYNPRDISLPYALFTSPSVVVWDGQRGYKNLFDATLDALYSALERASGGSLEVVVSESGWPSAGAFAATFDNGRTYLSNLIQHVKGGTPKRPNRAIETYLFAMFDENKKQPEVEKHFGLFFPNKWQKYNLNFSAEKNWDISTEHNATILFLKSDM
The following text describes a protein:
Function:
Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MNNLFQPTALDSCTSPSSQTLALLKSASLTHAQYDPADPLGKLMAYATLTPIALLVAYTTQCLFSRDLASGFMLLGQLVNEGVNYILKNSIRQDRPTDRLGKGYGMPSSHAQFIWYFAVYSSIYTLRNGLDKEHALIQRLYWQCDLHAFNTMMTRLRLEYHSLEQVCVGSAVGALMGVVWYVLVQQVLFPLAEYFQVVDGWIGQMFLLRDTRSVGGLMAAQRSWSRDESKSKNKHE
The following text describes a protein:
Function:
Diacylglycerol-binding protein.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The KxHxx motif mediates association with the coatomer complex.
Sequence:
MRLRISEAVVLFLLGAVAALIGDHSHVVTGTTVYHTDAVPFVWSSPFWFPILVGAATASLAELRLHLPAPRDGVTARQALGGVAAVVGTYVTTALVHAFPVVPVTALVCAAAAITWCVLGDGPGAACGVVIAVIGPAVEIALVQLGVFAYHPDSDGLFGVAPFLAPLYFAFGVVAALLGELAVARRPQLGPPVCDTVSRGPGAG
The following text describes a protein:
Function:
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6. Mediates homotypic interactions with cells that express ALCAM. Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation. Required for normal hematopoietic stem cell engraftment in the bone marrow. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity); [Isoform 3]: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: Secreted form, inhibits isoform 1 homophilic interaction.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells. Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse; [Isoform 3]: Secreted.
Domain:
The CD6 binding site is located in the N-terminal Ig-like domain.
Sequence:
MESKGASSCRLLFCLLISATVFRPGLGWYTVNSAYGDTIIIPCRLDVPQNLMFGKWKYEKPDGSPVFIAFRSSTKKSVQYDDVPEYKDRLNLSENYTLSISNARISDEKRFVCMLVTEDNVFEAPTIVKVFKQPSKPEIVSKALFLETEQLKKLGDCISEDSYPDGNITWYRNGKVLHPLEGAVVIIFKKEMDPVTQLYTMTSTLEYKTTKADIQMPFTCSVTYYGPSGQKTIHSEQAVFDIYYPTEQVTIQVLPPKNAIKEGDNITLKCLGNGNPPPEEFLFYLPGQPEGIRSSNTYTLTDVRRNATGDYKCSLIDKKSMIASTAITVHYLDLSLNPSGEVTRQIGDALPVSCTISASRNATVVWMKDNIRLRSSPSFSSLHYQDAGNYVCETALQEVEGLKKRESLTLIVEGKPQIKMTKKTDPSGLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSKIIISPEENVTLTCTAENQLERTVNSLNVSAISIPEHDEADEISDENREKVNDQAKLIVGIVVGLLLAALVAGVVYWLYMKKSKTASKHVNKDLGNMEENKKLEENNHKTEA
The following text describes a protein:
Function:
Potent competitive inhibitor of metallo-carboxypeptidases CPA1, CPA2, CPB, CPN, and TAF1a. Also inhibits human CPA4. Accelerates fibrinolysis in vitro and may contribute to the maintenance of host blood liquidity during feeding.
Subcellular Localization:
Secreted.
Sequence:
MAATLPVFAVVFFAMVLASSQANECVSKGFGCLPQSDCPQEARLSYGGCSTVCCDLSKLTGCKGKGGECNPLDRQCKELQAESASCGKGQKCCVWLH
The following text describes a protein:
Function:
Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence. Promotes iron uptake and usage along the endocytosis pathway under iron-limiting conditions.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MIAKQKIKILIGVIIVIATYHFIVSSNVRSKDLSDLVDLGSSDKSTTENERPKNNIVTNNRLDNPPNEDIPHAEPDSPPQEPPKSGNKPDFSIFFEGLEKFAIKQPGIKDKYTSEKAKEKFSTDDNFLFGKEYLENVLDIPQATFKELKDSHKRYVDEHIPKMLQRVKTFGSLAPSDKEWESYKGSSGYIIVGGGRFTWLSFLVIKQLRATGAKLPVEMFIATESDYEKEFCEKVLPKYNARCNVFDYKLADDLKKRFDIGGYQYKMLALLSSKFENVLYLDSDNFPTRNVDYLFESDLYKENNLLLWPDAWARTTNPKYYEIAGVPVKENKLRYSKYDEKQAGGKDKLKPLSEYTFKDSWYHDFEGTLPDPTSETGMFMVNKSSHLKTLLLCLYYNVFGPQYYYPLLTQGSAGEGDKETFIAAAHVMKEPWYQCARQFKWTGYVSKVDNKFTSKALAHYDPVQAQDTTRQDVDIIFMHLSYPKFYPNWLADNHDLVYADTDEHIRMYSSINKNVGYDFDLRVMQFFTEGLCPNYYDSKTGKPIENIPHIDYTNDYMGNHLMYVKDEEQNNIDRCNKVFIPHLKWLKETAEIPTVVS
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MSSTTKKITLKSSDCKSFEVSEPVAMESQTIKRMMEENCGNNDILILNVKSKILAMVIEYCKMHVEADLDSEFVKVNYSDYLTVKAIECSKKLFNEVNEAWGVTGNVLAKGIDYCEKHVDDAAANASSSDLKVWDAKFVRQIDMDTLCDLMLAANYLNIKGLLDLTCRAAPDQARREKEQIFFKFAIALVLFWIFFR
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
MAAPMRALGSGVPRVARAGVARGPAPLNSFWRSYGWGAEKTKESQFTFDDHQAIFEGRTTPDLLKSLLVLRLCSTPSFVASAEGLLANARRVMGDSTALSFVRTTFYQHFVAGKDSGDVWGRMNTLRANGVGAILDYAEEEDLLTACKQPAPPATKASAGAAAGGAAQVSARDPLGGESLIESGVAARTYTFQDDATCELRTQAFLAAIDTAATLPGQGFAAIKLTALGDPALLELLASALDAVKALFRRYDSNGDGFVTRQGFLEAFERIEKAQGRSSTGAERNEMWAWLDPAGDGRVDYVTWASRLDLRRLPDMAASLRQELESQTDARGRQWEMSAEELRQLEALFGRLQRLVAQAVKKGVKLMIDAEQSHLRPAIDHIGRELMREHNKPVSAGGEGAVIFMSYQSYLRDVELRLQRDLERAERQGYVLGAKLVRGAYLHLERRRAAQAGTASPVWDHMRETTAAFDGCLDTLLRGVQAGRAELMVGTHNRSSVEGVIERMNKLGLEPEEAHVYFGQLLGMADNISFTLGQHGYKVFKYCPYGQVDKVIPYLMRRINEAQYTRKGGKEDAALLLEELMRRLRDPAHSPIARIFSTASS
The following text describes a protein:
Function:
Modulates pharyngeal pumping activity, at least in part by regulating expression of the acetylcholinesterase genes ace-1 and ace-2.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton.
Sequence:
MREGTPRVRIEVNKGSNRPSQFVSESEEQRLQRVQSRDSDTATMNFVTDDRMMEEHDEYSAFKEAYEEEESREYVIENGVKRLVNQHYDSRGYSSAGRGQKGRREEERRRNMAVDYSSQDFRQSLAAIDQASRDGAISRGEDGVRVRQIGDTTIMTEHRDPYSFYWQLDQARREAESPPRRPPPTDYVIDEEEEVLETVYSPEADDVMFENQYRRPVRHPLPPPPPIMEEEPKDLPPGWEKHEDPQGYSYYWHVDSGTIQRQPPPPVNRETQADAPPPQIIQLPPQQPVIEEHAFKQTTTKRRIEQDEMSEREIEDVAMIENGDTYHKPVRFAVRSLGWTDISEDELTAEKSSRAVNRAIVDLTTRSDIDSIPKWGDGRELIMELDDNELALLDPDSMNVIHSERIQAIRVWGVGRDNGRDFAYVSRDRGTRRFMCHVFRCDTSAKTIANTLRDICKRLMLHRRPSSLHAIESGEKRIVRSEGLTAPIDEPRKVIRCHFLGVTQVPKATGIEILNEAVDRLVSQVRSERWILADVSIAPSTIAIVEVNGQQIAECRVRYLSFLGIGRDVKHCAFIMQTSSESFMCYVFHVEPNAAAMAKMVEAACKLRYQKVLDAHSSSRHHSGMSIHGQHPPSTYHGKGWTETFRDAFGSVTSRMVPSRSAQRL
The following text describes a protein:
Function:
Acts as a modulator of macrophage activation through control of glucose metabolism.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAKTKYVLGIDLGTSSIKATLLEIKSKWSHARYSEQTSASIQSENHNFAIQDPDKILKTLERVLFKFERKDLENVTKISICGQMHGCMFWKKDYLFTLLQTRGKDDGIHLDKESVSSLITWEDRRCTDGFLSSLPNPSTNIPISTGYGCASIFWLTRNKPGFLDKFDCSGTVMDFVVSMFCCSLRCGIMSSHNAVSWGYYDNLNKRWELESLQAAEFPVHLLPNVYEPGTIVGLLFTDYCGIPKGTPVGAALGDFHCSMYACQQNKTDAVLNIGTSSQFAILAPVNHQLSVDENESCEAWQMWPYFKGDQVMVAASLHGGNVITHFAETVKSWMEELKIQEIPNTETIYKNLLASADSMTTLAIRPTIWGERHSTNLTGMVSNILSGNTSLGDITAAICQGMLANLHEMLPGERSRRCGVKRIVGTGRALVQNDLMQELVKQVWGLPLVLCKENDASLGAALAVLECN
The following text describes a protein:
Function:
Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Localization:
Cytoplasmic vesicle. Nucleus.
Sequence:
MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI
The following text describes a protein:
Function:
3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation. In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MSAALVGYSSSEDEEEEEEEEEGRGGTRGSRRLPVPECVLAMFREEERDEKRDDSSRHGGRVRCFPHERGGWATHVYLPYQAQEEFLELLELLASHARTYVPSVTAMEEFHVSLSQSVVLRYHWISPFMQSLKERLAAFHRFFCVADRVKVYTNQNKTRTFVGLEVSTGHFQLLELVSEVDKVMEEYDLPVFYKDPSFHISMAWCVGDLRGSLEGQCLQELQDIVDRTRWGRASQSPKTNKEPFCSTAPDAGGSHTPPTLFLCAQQLCGVCGLKPRHFQVRVVGVRYACLQQISYSSVLSAARMCCSQHWWLQSELLILLILKKKEKKKKPSV
The following text describes a protein:
Function:
May act as a carbohydrate transporter.
Sequence:
MCAVVLMLPDVSATRWTVGGNQGWSTNVNYTVWAKDKHFYNGDWLFFVYDRNQMNVLEVNETNYESCNSDHPLHNWTTGAGRDVVPLNVTRKYYFLSGKGFCYSGMKIAINVENPPPPPSASPIKESNDSPSSNYRGQIVVPAVFAIAAVWDSFLRLYW
The following text describes a protein:
Function:
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Subcellular Localization:
Cytoplasm.
Sequence:
MPMTGFYETISPRDQQRPPIWFLRQVGRYIPQYQELKRNRSLKDFFLDTESIVEATLLGPSLLGVDAAIVFADILSILEGFSVDYRFAPGPEVSYSPHEPLIFTKDPQETFSFLLEAIQQLTKRLTVPLIAFAASPFTLASYLIEGGASRDYPKTIAFLYQYPDRFKALLDEITLGTATYLQMQVQAGAAAIQLFESSSLRLPPHLFAKYVVAPNTKLIRQIKQTGNPPISLFCRCFYQEFLSLYAIGADTLHPDYHVELPEVYRQIHSPGSIQGNFDPALLLLPQDALIAHLEAYLAPLKQQSHYIFNLGHGILPQTPIENVQAVVSCLTSISTS
The following text describes a protein:
Function:
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of the flowering autonomous pathway which positively regulates flowering by promoting transcriptional repression of the flowering repressor FLC. May promote histone deacetylation at the FLC locus leading to the formation of repressive chromatin structures. Forms a histone deacetylase complex with HDA5, HDA6 and FLD that represses FLC gene expression to control flowering time. Also negatively regulates cold-responsive genes. Acts together with PDP1 and MSI5 to regulate the function of the PRC2 complex on FLC. Required for systemic acquired resistance (SAR) toward pathogenic bacteria (e.g. Pseudomonas syringae pv tomato DC3000 (avrPto)). Together with FLD and MSI4/FVE, contributes to dehydroabietinal-dependent (DA, a diterpenoid tricyclic diterpene) activation of flowering ans SAR.
Miscellaneous:
MISCELLANEOUS: Binds zinc.
Subcellular Localization:
Nucleus.
Domain:
The DWD box is required for interaction with DDB1A.
Sequence:
MESDEAAAVSPQATTPSGGTGASGPKKRGRKPKTKEDSQTPSSQQQSDVKMKESGKKTQQSPSVDEKYSQWKGLVPILYDWLANHNLVWPSLSCRWGPQLEQATYKNRQRLYLSEQTDGSVPNTLVIANCEVVKPRVAAAEHISQFNEEARSPFVKKYKTIIHPGEVNRIRELPQNSKIVATHTDSPDVLIWDVETQPNRHAVLGAANSRPDLILTGHQDNAEFALAMCPTEPFVLSGGKDKSVVLWSIQDHITTIGTDSKSSGSIIKQTGEGTDKNESPTVGPRGVYHGHEDTVEDVAFSPTSAQEFCSVGDDSCLILWDARTGTNPVTKVEKAHDADLHCVDWNPHDDNLILTGSADNTVRLFDRRKLTANGVGSPIYKFEGHKAAVLCVQWSPDKSSVFGSSAEDGLLNIWDYDRVSKKSDRAAKSPAGLFFQHAGHRDKVVDFHWNASDPWTIVSVSDDCETTGGGGTLQIWRMSDLIYRPEEEVVAELEKFKSHVMTCASKP
The following text describes a protein:
Function:
Involved in the export of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRSAVLFIYFFLLNIFLFQPAVIHIQSNYILFMSIVSAPLPALSALIILAHYHGIAANPADIQHEFCTSAQSDLNETQWLLAAKSLGLKAKVVRQPIKRLAMATLPALVWCDDGNHFILAKTDGEGEHAQFLIQDLVTNKSAVLSFAEFSNRYSGKLILVASRASVLGSLAKFDFTWFIPAVIKYRRLFFEVLVVSVVLQLFALITPLFFQVVMDKVLVHRGFSTLDVVSVALLVVSLFEIVLGGLRTYLFAHTTSRIDVELGARLFRHLLSLPLSYFEHRRVGDTVARVRELEQIRNFLTGQALTSVLDLAFSFIFLAVMWYYSSTLTWVVLASLPAYAFWSAFISPILRTRLNDKFARNADNQSFLVESITAVGTVKAMAVEPQMTQRWDNQLAAYVASGFRVTKLAVVGQQGVQLIQKLVTVATLWIGARLVIESKLTVGQLIAFNMLSGQVAAPVIRLAQLWQDFQQVGISVARLGDILNAPTENASSHLALPDIRGEITFEHVDFRYKADGRLILQDLNLRIRAGEVLGIVGRSGSGKSTLTKLVQRLYVPEQGRVLVDGNDLALAAPAWLRRQVGVVLQENVLLNRSIRDNIALTDTGMPLERIIEAAKLAGAHEFIMELPEGYGTVVGEQGAGLSGGQRQRIAIARALITNPRILIFDEATSALDYESERAIMQNMQAICANRTVLIIAHRLSTVKTAHRIIAMDKGRIVEAGTQQELLAKPNGYYRYLYDLQNG
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MENEKIPSVYEHGSCSRSAEPEPRPNDSRILGRKYHLYWALGFGSSAIVKLASDVTTGHGVAIKIFDKEFIDGKKKSVKKRMKIALEREISAMTMLRSHPNVVRIIEVMATTTRVYIVMELVVGGATLLDKIGRTSGMSETQARQYFHQLICAVDYCHSRGVIHRDLNPSNLLLAADGVLKVSDFGMTALPQQARQDGLLHSACGALDYKAPEVIRNRGYEGEKADIWSCGAILFHLVAGDVPFTNILQADFICPSFFSASLVALIRRILDPNPTTRITMNEIFENEWFMENYEPPRFYRQNFTFALDMINDSNLDVNVPNLVHRIHKSVLLRGMEQGLQHHQETSFISQNPVDEIIDGIERVAGIMGFDVKRINSFRMSIEGGANARRKGHLAIFIKISEIAQPFHMVELRKAEGDVLEFHNFCKHIYAALSDFIWKGRAEPIDTETDG
The following text describes a protein:
Function:
Calcineurin-dependent protein required for growth under high NaCl, alkaline pH and cell wall stress.
Miscellaneous:
MISCELLANEOUS: Present with 251 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Punctate foci at the endoplasmic reticulum membrane. The distribution of FRT1 on the endoplasmic reticulum membrane depends on CaCl2 and calcineurin activity.
Sequence:
MNLLIDRMENPGSRNCTLLPPSFPRGFCKGRRASSGDAVKIKESGLQPQPQPEPLQAKTNVAHFSKSSSRLPVIAVNDNPVVPRPSTEVNLGSLLQKEREKEKEEQPALHDRRHLYVTKNRAHGVRQRSLEMTSLPVLGSTKTGKFSDFLFEDDIDNRVGRHSRSYSGASSLDDPFRVSPKTDFNSNRARLSCLSKGRRGSMSVFQSCHTGLAFNQIQGSSSSQRRSSAGSFDYERKRLVNQFLQPSLGNSDPFDTLRESVVFEPSSTAGGIKLGNMHSQSQISVNSSPSTSLFYHDLDGSAVNDSSSFLYSRSNVPAFLSSSAFSSTSSTSSDSEDVDRRSLNGVYPSLGYLTNQRKPRNSSGSSTAPGTDTLGFKYLLNRQKSADSSTRFKSVLKVNNNNGSAATPDSSSNSISKSNSNLNDNIDELNYYQNHISTLLVKIENEMRRNLNDTIIKNENNVQKTIQKYDLLSGELTLLLDEMTTLRTTVINQFLVKLKSDFDEDDNKAFINELKISVEESVAQLQGLERRMEVCQERLNKQKSSLREMDSLIELKNVLNKSKNNTKSIYLYRYFIIDIIAFLLMGGFIVYVKNLLTRFFTR