lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis.
Sequence:
MELRCGGLLFSSRFDSGNLAHVEKVESLSSDGEGVGGGASALTSGIASSPDYEFNVWTRPDCAETEFENGNRSWFYFSVRGGMPGKLIKINIMNMNKQSKLYSQGMAPFVRTLPTRPRWERIRDRPTFEMTETQFVLSFVHRFVEGRGATTFFAFCYPFSYSDCQELLNQLDQRFPENHPTHSSPLDTIYYHRELLCYSLDGLRVDLLTITSCHGLREDREPRLEQLFPDTSTPRPFRFAGKRIFFLSSRVHPGETPSSFVFNGFLDFILRPDDPRAQTLRRLFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLKPDAVLHPAIYGAKAVLLYHHVHSRLNSQSSSEHQPSSCLPPDAPVSDLEKANNLQNEAQCGHSADRHNAEAWKQTEPAEQKLNSVWIMPQQSAGLEESAPDTIPPKESGVAYYVDLHGHASKRGCFMYGNSFSDESTQVENMLYPKLISLNSAHFDFQGCNFSEKNMYARDRRDGQSKEGSGRVAIYKASGIIHSYTLECNYNTGRSVNSIPAACHDNGRASPPPPPAFPSRYTVELFEQVGRAMAIAALDMAECNPWPRIVLSEHSSLTNLRAWMLKHVRNSRGLSSTLNVGVNKKRGLRTPPKSHNGLPVSCSENTLSRARSFSTGTSAGGSSSSQQNSPQMKNSPSFPFHGSRPAGLPGLGSSTQKVTHRVLGPVREPRSQDRRRQQQPLNHRPAGSLAPSPAPTSSGPASSHKLGSCLLPDSFNIPGSSCSLLSSGDKPEAVMVIGKGLLGTGARMPCIKTRLQARPRLGRGSPPTRRGMKGSSGPTSPTPRTRESSELELGSCSATPGLPQARPPRPRSAPAFSPISCSLSDSPSWNCYSRGPLGQPEVCFVPKSPPLTVSPRV
The following text describes a protein:
Function:
Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVAPPPPPPPDYMLPPGLHAPEPKGLAAGPPTGPLGDFGAPTLPMAVPSAHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGPPYGYPEPFSGGPGVPELIVQLLQLEPDEDQVRARIVGCLQEPAKGRPDQPAPFSLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQIQHGKEGSILLVTGQEVELTTVAAQAGSLLHGLVLRAQELVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSLVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
The following text describes a protein:
Function:
Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
Subcellular Localization:
Bacterial flagellum basal body.
Sequence:
MSSPFTSFLGIHGDALTLREQRMKLIASNLSNVDTPGYKAKDLNFEAALKAAEGVRDGGLMQATDAKHYEIGSTAGLNPFQITREADQPSLDGNTVDPDAERAAYGRAALEYRASLSFLESKVRSMLTAITGQ
The following text describes a protein:
Function:
Probable electron transporter required for biotin synthase activity.
Sequence:
MADITLISGSTLGGAEYVAEHLAEKLEEAGFTTETLHGPLLEDLPASGIWLVISSTHGAGDIPDNLSPFYEALQEQKPDLSAVRFGAIGIGSREYDTFCGAIDKLEAELKNSGAKQTGETLKINILDHDIPEDPAEEWLGSWVNLLK
The following text describes a protein:
Function:
Part of the chromatin structure-remodeling complex (RSC) which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and required for cell cycle progression (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSQLLPQAYLTNFHNRIRNEDVPLFITAAPTRNHKRAKVVNYSEYDNDLLLDDFIEQDQNDDDEKVHSDNGKGEGEEVGHEDAVASNNNLPDLEQQDDPTGILRYPRIRETFLQSKIAVRYEQVLEAGVGGSGEAVGIAEDEGAGAYSSSSQPVVIPIRLNLEHNGHKIIDFFTWNLNDHSLTLEQFAQIYCQDLDFAHNLSLQNQIVAAINDQLQEYETLASVVVPDLHVIINLTCNLDSKLYEDNFEWNLNDQTLSPEQFAELVVQDLGLTREFMPAIAHALYESILKIKKDWLEGHLNPEHVANGAAFGCLSGIRLDIDTLGSNWCPKVEVLSQWEIEKREIEKERNMRRLKRESAKVDDRLARRRGKRRMDDLETTMRI
The following text describes a protein:
Function:
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
Subcellular Localization:
Cytoplasm.
Sequence:
MILFFRTPSKSVIAVESNHQLTPDESNKLCWLFGEAVTESEENLKGCFVGPRREMITPWSTNAVEITQNMGLEDILRIEEYFPVKDENADYDPMLQRMYKGLDQNVFTTNRQPEPIVSIEDLEAYNEKEGLALSKEEMDYLKKVENDLGRKLTDSEVFGFAQINSEHCRHKIFGGTFIIDGVEQESSLFQMIKKTTQENPNKIISAYKDNVAFAEGPVVEQFAPADHSKPDFFQVKDIKSVISLKAETHNFPTTVEPFNGASTGTGGEIRDRMGGGKGSWPIAGTAVYMTSYPRTDEGREWEDILPVRKWLYQTPEQILIKASNGASDFGNKFGQPLICGSVLTFEHTENNEVYGYDKVIMLAGGVGYGTQRDCLKGTPEAGNKVVVIGGDNYRIGLGGGSVSSVDTGRYSSGIELNAVQRANAEMQKRANNVVRALCEEDVNPVVSIHDHGSAGHVNCLSELVEECGGLIDMSKLPIGDKTLSAKEIIANESQERMGLLIKEEAIEHVRKIAERERAPMYVVGETTGDHRFSFQQADGVRPFDLAVEQMFGSSPKTYMIDKTVERHYEMPEYELPKLHEYLTNVLQLEAVACKDWLTNKVDRSVTGKVARQQCQGELQLPLSDCGVVALDYRGEKGIATSIGHAPQAALADPAAGSILSVSEALTNLVWAPMAEGMDSISLSANWMWPCRSQEGEDARLYTAVKALSDFCCALQINVPTGKDSLSMTQKYPNGEKVISPGTVIVSAGGEVSDVKKVVSPVLVNNEKTTLYHIDFSFDELKLGGSAFAQSLGKVGDDVPCVQDAEYFRDAFLAVQELVNKGLILAGHDISAGGLITTLLEMCFANVEGGMEISLDKMKEQDIIKILFAENPGIVIQISDKHKEEVKKILEDAGVGFVKLGKPTDERHILVSKGDATYQFGVDYMRDVWYSSSYLLDRKQSMNGCAKKRFENYKMQPVEFAFMPGFKGKLSQYGITPDRRTPSGVRAAIIREKGTNGEREMAYSLYLAGFDVKDVTMTDLISGRETLEDVNMIVYCGGFSNSDVLGSAKGWAGGFLFNPKAKEALDKFYAREDTLSLGICNGCQLMMELGLINPEHEKKGKMLHNDSHKFESTYVGLTIPTNRSVMFGSLSGSKLGIWVAHGEGKFSLPYDEDQYNVVAKYSYDEYPGNPNGSDYSIAGLASADGRHLAMMPHLERAIFPWQNGCYPADRKNSDQITPWIEAFVNARKWVEEKTK
The following text describes a protein:
Function:
Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MSVQSPLIAVPRKTTTDVDWATPIRHVIAASYGEDPNSYAEECAVLQRCRQDAVRGAGNDQTARDLLYKYFGQLELLELRFAEIKVSFPWNDAFTDKLTTQTSLAFEKASIIHLISSILSSLAQSASRSDPEGLKRAYYNTRATAGMLTYINENFLHAPSTDLSREVVHLLIGIMMAQAAEIFTEKLVEEKKSASLVARSANQTASMYTSVVDEMKEFQGKGVFDRNWLYVLQIKAKLFGSLAQYYKATSDSAAGKHGTALVRLKIANSLIQDAQKQASSFIYTFVAASTPSLPHDAANALNEIVKAHATVCGEAKEQAVKDNDLIYHEVLPSEASLPAIEKLPPAAPITIQDVYGNQEVTKLIGPDIFLRLVPLAVHESASVYSEEKAKLVRAEVDKVELAEGEIQAGLDHLNLPEEIDRWRQFLEGDTNDDVPLSQQLKSLVDSVGDVRQVENDLGRLDGERAACERELRELNGALDAESRECERMRAKYTPNFTQSPSGPQTANLRSNLSANLSALSSASTSDAHLQSLWQSIQPSISLLSSGPSNLERAARDITEGNPQKIDKTVSLLDLDDEEVDRKALGQEEKDALRKAVDDGREKLDRLKKIRAERDEVLRDLKEKIQTDDVSNLLLLNRRSQNVEPQLFASELEKFRPYQTRLAAAVSASRSILQELDMLVAQVHKGTGFREILRKEKDRQRIIRDWEKRLIEAGESYAEIRAGLGKGLSYYDSLRRVIEDLRMEVQRFTNSREQERRNMVSDIETRQRLGGTSPSTGGVVANRGLEERLAALKMEAPPQPPRLGTTSTPNLPPPPGRGSSNVTSSYLPPPPPPKPQSNPYDFSTLAGFGSFATPSVSSPQHVYPSQPQQAYNQQSYIPPQQNPYYPPPPSRPTYASPPFAPQQPPMQSGHSPYAPPPGHAPQPQQPQYPSSQNQQQRQGYKYPGYGQQGGYGGGYGQY
The following text describes a protein:
Function:
F-actin cross-linking protein.
Domain:
The rod domain contains six 100-residue motifs that appear to have a cross-beta conformation.
Sequence:
MAAAPSGKTWIDVQKKTFTGWANNYLKERILKIEDLATSLEDGVLLINLLEIISSKKILKYNKAPKIRMQKIENNNMAVNFIKSEGLKLVGIGAEDIVDSQLKLILGLIWTLILRYQIQMSESDNSPKAALLEWVRKQVAPYKVVVNNFTDSWCDGRVLSALTDSLKPGVREMSTLTGDAVQDIDRSMDIALEEYEIPKIMDANDMNSLPDELSVITYVSYFRDYALNKEKRDADALAALEKKRRETSDASKVEVYGPGVEGGFVNKSADFHIKAVNYYGEPLANGGEGFTVSVVGADGVEVPCKLVDNKNGIYDASYTATVPQDYTVVVQLDDVHCKDSPYNVKIDGSDAQHSNAYGPGLEGGKVGVPAAFKIQGRNKDGETVTQGGDDFTVKVQSPEGPVDAQIKDNGDGSYDVEYKPTKGGDHTVEVFLRGEPLAQGPTEVKILNSDSQNSYCDGPGFEKAQAKRPTEFTIHSVGADNKPCAAGGDPFQVSISGPHPVNVGITDNDDGTYTVAYTPEQPGDYEIQVTLNDEAIKDIPKSIHIKPAADPEKSYAEGPGLDGGECFQPSKFKIHAVDPDGVHRTDGGDGFVVTIEGPAPVDPVMVDNGDGTYDVEFEPKEAGDYVINLTLDGDNVNGFPKTVTVKPAPSAEHSYAEGEGLVKVFDNAPAEFTIFAVDTKGVARTDGGDPFEVAINGPDGLVVDAKVTDNNDGTYGVVYDAPVEGNYNVNVTLRGNPIKNMPIDVKCIEGANGEDSSFGSFTFTVAAKNKKGEVKTYGGDKFEVSITGPAEEITLDAIDNQDGTYTAAYSLVGNGRFSTGVKLNGKHIEGSPFKQVLGNPGKKNPEVKSFTTTRTAN
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Cytoplasm.
Sequence:
MEPQSEVNPKRVAAFFRRSNIGPVCRVQSSSDMEAWLASRAYFTLITYLNDVSAEIQGIRNTDLFPISKNIKRLTTIFEQLDSMIVANSPAPLVLGANMDSRTKSYRRWAHGMLRDIYKIVEKAVPSSKCRHVNELGVYLSGSFGSSAKIEYGTGHELSFLFFVCALFKAEILDKEQDLAASALVLFDRYLHFVRRLQVTYSVNSSNWHGGYSLDKFQFVPFVWGFAQLCHEAPFSPKKMLDEDTIAKYRDAYMLINCVGHMATTNVGTFARHSSQLWSLAALSSWTKIHRSLMFMYMEDILMDIDNLNALRFGELMSFEEDKSGRHLGSARMGVKSPLRRQMAEDPDDQDQDQDLTSRSGTPSISRSEQNDSARKKAKVEETSSDCMSNSGLSLGSECTSLSGVSVHLPTWLDDCTATSKNAF
The following text describes a protein:
Function:
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.
Subcellular Localization:
Endosome membrane; Multi-pass membrane protein.
Domain:
The first transmembrane domain may act as a type I signal anchor. The PAL motif is required for normal active site conformation.
Sequence:
MESLWKLSYLLEPASLALILTAVSVAYASASRALDHGREMERNLDFSEASITLDRSQALMIPLASSCSLLLMFYLFSSVSHLVTAFTAVASAMALFFCLSPYVNCVRSRLGVGDPFVSRCCSKPFTRLQGLLVAICVGTVVAWLVSGHWLLNNLLGISICIAFVSHVRLPNIKICALLLVCLFVYDVFWVFFSERFFGANVMVSVATQKASNPVHTVANKLSLPGLQLITKKLELPVKLVFPRSLMGGLAPGSSPGDYMMLGLGDMAIPGMLLALVLSFDHRKIKDMSVSQDMPPSKQRKYVWYALTGYGVGLVTALAAGILSQSPQPALLYLVPSTLGPVMYMSWLRNELWELWEGSRPIINDKAHLLEV
The following text describes a protein:
Function:
GTPase-activating protein (GAP) for CDC42 and less efficiently for RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase.
Miscellaneous:
MISCELLANEOUS: Present with 752 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDNLTTTHGGSTTLELLAQYNDHRSKKDKSIEHIEKGTCSGKERNPSYDEIFTENIKLKLQVQEYETEIESLEKVIDMLQKNREASLEVVLEQVQNDSRDSYVNDQSFVLPPRSAERKAHIKSLNLPIPTLSPPLQQGSDVALETSVTPTVPQIGVTSNTSISRKHLQNMILNDEIEANSSFSSPKIINRSVSSPTKIHSEQLASPAASVTYTTSRITIKSPNKGSKSPLQERLRSPQNPNRMTAVINNHLHSPLKASTSNNLDELTESKSQQLTNDAIQKNDRVYSSITSSAYTTGTPTSAAKSPSSLLEVKEGENKALGFSPASKEKLDDFTQLLDSSFGEEDLVNTDSKDPLSIKSTINESLPPPPAPPTFFSPTSSGNIKNSTPLSSHLASPVILNKKDDNFGAQSAKNLKKPVLTSSLPNLSTKLSTTSQNASLPPNPPVESSSKQKQLGETASIHSTNTLNTFSSTPQGSLKTLRRPHASSVSTVKSVAQSLKSDIPLFVQPEDFGTIQIEVLSTLYRDNEDDLSILIAIIDRKSGKEMFKFSKSIHKVRELDVYMKSHVPDLPLPTLPDRQLFQTLSPTKVDTRKNILNQYYTSIFSVPEFPKNVGLKIAQFISTDTVMTPPMMDDNVKDGSLLLRRPKTLTGNSTWRVRYGILRDDVLQLFDKNQLTETIKLRQSSIELIPNLPEDRFGTRNGFLITEHKKSGLSTSTKYYICTETSKERELWLSAFSDYIDPSQSLSLSSSRNANDTDSASHLSAGTHHSKFGNATISATDTPSYVTDLTQEYNNNNNISNSSNNIANSDGIDSNPSSHSNFLASSSGNAEEEKDSRRAKMRSLFPFKKLTGPASAMNHIGITISNDSDSPTSPDSIIKSPSKKLMEVSSSSNSSTGPHVSTAIFGSSLETCLRLSSHKYQNVYDLPSVVYRCLEYLYKNRGIQEEGIFRLSGSSTVIKTLQERFDKEYDVDLCRYNESIEAKDDEASPSLYIGVNTVSGLLKLYLRKLPHLLFGDEQFLSFKRVVDENHNNPVQISLGFKELIESGLVPHANLSLMYALFELLVRINENSKFNKMNLRNLCIVFSPTLNIPISMLQPFITDFACIFQGGEPVKEEEREKVDIHIPQV
The following text describes a protein:
Function:
Acts as a ribosome collision sensor, splitting the ribosome into its 2 subunits. Detects stalled/collided 70S ribosomes which it binds and splits by an ATP-hydrolysis driven conformational change. Acts upstream of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation. Probably generates substrates for RQC; Endonuclease that is involved in the suppression of homologous recombination and thus may have a key role in the control of bacterial genetic diversity.
Sequence:
MSAGMSIPESSLITLEFDVIRDRLAQYTAFSASRELALSLTPATDLAEVRRRQALTAEARLLLEEWPEVSIGGARDVRRAVQHAARGGILDGTTLREIAATLQSAALLRQRLSRLDERFPLLIDLANTLPVIPSLSEAIDRAIGDDGQVLDSASPTLARLRHEVRVAFNRLQERLQSMIHSSALAGALQEPIITVRNGRYVIPVKASHRREVRGLVHDQSGSGATLYIEPMAIVELNNRWRELQSAEAEEVQRILSTLSDQVGAAANLITSTVNTLATLDLAFALARYAIATRSTAPEIVDWRPDDPPSPEPPLRLTRARHPLLPAETVVPIDLWLGGEFSLLLITGPNTGGKTVALKTTGLLALMAQAGMQIPADQPSRLPVFQYIFADIGDEQSIEQSLSTFSSHMANIIRVLQTLTAAQQMPSESDAYALFDDRRPAALVLFDELGAGTDPVEGAALARAIIGRLLELGVLGIATTHYAELKAFAYTTPGVQNASVEFDIETLAPTYRLSIGIPGRSNALAIAARLGLDPTLIEQARSFIDRKEAQVEDLLAGIQRERDAAAAALQRAEELRLDAERYRDRLAAEQQAFAAERAAALEAARAEIEAELREVRQQLRRLREEFRTVNISRQWLEEAEKRLATTAEQSQQAVARLNVQTQPAPPPPAEKPLQVGDQVQVTSIGLNGEIVAIDEEDQTATVQVGGFRMTVSFNDLKRAKGKSDDGQRFTPPARTVHLPPTPDVSMTFDMRGWRAAEVSDRLDRYLNDAYLAGLHQVRLIHGKGTGALRQVVRELLAGHPLVASFSSGGRDGGDGVTIATLVDR
The following text describes a protein:
Function:
Protein adapter that acts as an essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells. Recruited to young transposons, which are specifically marked with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3), via its association with SPIN1 chromatin reader, and associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes. Following this, PIWIL4 engages with nascent transposable element transcript to direct piRNA-directed DNA methylation. Not required for piRNA biosynthesis.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MLLLSATAVHDLLGTAFKGVRSCAFGGQRTPALRLASASPSEELEVTAQPVSKVRRGQGLAAPTDIASSSLEPATSKAHSGPSMGQRRSKCTKRLRRGPVLHAQHWGTDRRADKSSQDQPEGSSAGSFPKLLGSGPVIHLLGAISHGQAGEPQPPKLEVLENMMEVSLASLVQRPRRKERSMAQGPSRCQEGAPVQEAWPECPGSVPVKAEEEEPGEQDGGEDSAQLQPQQEKLSLDVGVRNTVVHAMQEVLRSRLQELPDLVLSEEAVEGIAAGIETALFNLTQTTSCRYKTKYRSLLFNLRDPRNPDLFLKVVRGDVTPEDLVQMSSIQLAPQELACWRDQEEKRGLEIIEQQQKELCSLPAFKLTHKGEVEILRDVDQTLTLEDLVEPMVSIDCSTLALPAPSKATTEQDKATTEQDEDTTEQHEHHFLDPSCRICMDWKPSCELPDSLTATRRMGDSVFQRAPSPALASSPEMPQTREKPPTQLQDRLQMPAGPTEALPGQPPWEGALDMFSIKRFRAKAQLVSGSSCQLLMALPEVIRSAGCIPSNTVWELLASICPAKAKDICVVRLCPQGARDTQNCRLLYSYLNNKQCHGLAAVEHVWVVLLPLPAFQLLPTRLRPLGGPGLEATHSSLVLAVLLPKAGLLDTAESSPLWEKVQKMTSFNRKVERRRHQPEDRSPNVAPKGSPPPRPALQQSQGNSSLAPRGICAWPRPPRGRGRVWGEPGTWQSPGRGQWPPKPGPCQSWHPYSAAPFGRGHHLHRASCPHWALLQHLESLVSMSYRLQASLISPGQGFHPATPAQPPTAPGNLGLHCQPPAAPEPPGQTPDSLGPSDGAGSECTFPRET
The following text describes a protein:
Function:
Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine and subsequent conjugation with cysteine and oxygen to form hercynylcysteine sulfoxide, the first two steps in the biosynthesis pathway of ergothioneine. May play a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTEIENIGALEVLFSPESIEQSLKRCQLPSTLLYDEKGLRLFDEITNLKEYYLYESELDILKKFSDSIANQLLSPDLPNTVIELGCGNMRKTKLLLDAFEKKGCDVHFYALDLNEAELQKGLQELRQTTNYQHVKVSGICGCFERLLQCLDRFRSEPNSRISMLYLGASIGNFDRKSAASFLRSFASRLNIHDNLLISFDHRNKAELVQLAYDDPYRITEKFEKNILASVNAVFGENLFDENDWEYKSVYDEDLGVHRAYLQAKNEVTVIKGPMFFQFKPSHLILIEESWKNSDQECRQIIEKGDFKLVSKYESTIADYSTYVITKQFPAMLQLPLQPCPSLAEWDALRKVWLFITNKLLNKDNMYTAWIPLRHPPIFYIGHVPVFNDIYLTKIVKNKATANKKHFWEWFQRGIDPDIEDPSKCHWHSEVPESWPSPDQLREYEKESWEYHIVKLCKAMDELSTSEKRILWLCYEHVAMHVETTLYIYVQSFQNANQTVSICGSLPEPAEKLTKAPLWVNVPETEIAVGMPLTTQYTSVGSNLQSSDLSAHENTDELFYFAWDNEKPMRKKLVSSFSIANRPISNGEYLDFINKKSKTERVYPKQWAEIDGTLYIRTMYGLLPLDDYLGWPVMTSYDDLNNYASSQGCRLPTEDELNCFYDRVLERTDEPYVSTEGKATGFQQLHPLALSDNSSNQIFTGAWEWTSTVLEKHEDFEPEELYPDYTRDFFDGKHNVVLGGSFATATRISNRRSFRNFYQAGYKYAWIGARLVKN
The following text describes a protein:
Function:
Probable member of the two-component regulatory system YxjM/YxjL. May activate YxjL by phosphorylation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFAVYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRLPSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAERNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHELTSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTALRGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAVISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSLPLMTTNKEQKDEQR
The following text describes a protein:
Function:
Transcription factor; part of the L-tyrosine degradation gene cluster that mediates the biosynthesis of the brownish pigment pyomelanin as an alternative melanin. Acts as a transcriptional activator for the genes of the tyrosine degradation cluster.
Subcellular Localization:
Nucleus.
Sequence:
MEIRRPSRHGNHPDRTYQRTYKACISCRQRKAKCDLGTGPDGLPLGPPCAKCRREQKPCLFDEKRAWERVKKRGTQSTSNLANSMMRTVVSSGNDALNILFEAANAQSQEDSMIESDSLPETEQHRSGHPVTSEGSSNQIDLTVPPDVLEKAMRPVELSHVSKDVLSTWEACRFVRMGWFTAREAVTFIDLFFKNMSILSPVLTDFYADHKNHRWLIAHDPVLCCTILMISSRYHVLPGVGGQSRNFFIHHRLWQHCQQLVTRLIFGQELSSQPKIRNIGTIEALLLMSDWHPRSLHFPPESDGWDSDLVTIDLESTEYGDDGSNSSAKRWAKDMSEPAKRSDQMSWMLLGSALSLAHELGIYETGDKARDAFVAYERFMTKDQMRLRRQRAQRLLYVYINQLAWRIGCVSLMPQGLSHSILNRQTSRELSQYGEEWLTFMDSWMDLTKLAKSVTDMFFPSVTFARQQLQSGRYIDLLDHFRPLLDKWKERYLQPQLHDKPFYDDIFIEYHFVRVYTHSVGMQAVVERAIADGNADEEEVRPMNIDPIDYEYIQEVIDGCCQILEKVTQLADIGALRFSPVRIFVRITSASIFLMKALSLGARQAKLRESLDVLERTIQALRSNALDDIHLSTRYATLLETHVSRLRRHLVASCKSLKRRRESTTRHSMVPPSYASATSDEHAPLITNPPVPQNMSDMGFTPSLNDIAADDWLSLPFDPSMAPFSISSGGQFPAYEGGGLNFLWNLPS
The following text describes a protein:
Function:
Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
Sequence:
MRERTVTYSPAFTLVPTRECFNRCGYCNFRADRGAAWLQPAEVRALLLPLVGSGVVEILVLSGEVHPHDPRRGEWFAMIEDICAVALELGFLPHTNCGVLSFEEMRALQQLNVSLGLMLEIDSNRLLGGVHRHAPSKIPALRTAQLEWAGALGIPFTTGLLLGIGETPAEREDTLRTIARLQDRHGHIQEVILQPHSPGGSQSWAGEPLGDAQLLGVVRLARQILPAEITIQIPPNLVGDPVPLLEAGARDLGGIGPVDVVNPDYAHPVVERLGERLAAAGWRLEPRLPVYPHLDKRVATALQPLLGEHRARLCQAAVT
The following text describes a protein:
Function:
Low-affinity peptide transporter that is necessary for proton-dependent uptake of di- or tripeptides, and to a minor extent tetrapeptides, in the intestine. Transport is independent of sodium and chloride ions. Controls the uptake of dietary fatty acids, plays a role in fatty acid synthesis and is responsible for dipeptide-induced acidification of the intestine. Regulates cellular pH differences together with the antiporter protein, nhx-2. Amino acid uptake and absorption levels influence the insulin signaling/daf-2 and let-363/TOR pathways, subsequently affecting the stress response and longevity of the organism. It is required for the uptake of the L-enantiomers of various amino acids, including L-glutamate. In response to the availability of amino acid nutrients, may play a role in promoting reproduction and fertility.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Note=Colocalizes with nhx-2 along the apical membrane of the intestinal cells.
Sequence:
MGYSESRSESVSSKGKTSYGHELETVPLPEKKIYTTWPDMIRHWPKTTLCIVSNEFCERFSYYGMRTVLTFYLLNVLKFTDSQSTIFFNGFTVLCYTTPLLGSIVADGYIGKFWTIFSVSILYAIGQVVLALASTKNFQSSVHPWMDLSGLLIIAFGTGGIKPCVSAFGGDQFELGQERMLSLFFSMFYFSINAGSMISTFISPIFRSQPCLGQDSCYPMAFGIPAILMIVATLVFMGGSFWYKKNPPKDNVFGEVSRLMFRAVGNKMKSGSTPKEHWLLHYLTTHDCALDAKCLELQAEKRNKNLCQKKKFIDDVRSLLRVLVMFLPVPMFWALYDQQGSVWLIQAIQMDCRLSDTLLLLPDQMQTLNAVLILLFIPLFQVIIYPVAAKCVRLTPLRKMVTGGLLASLAFLITGFVQLQVNTTLPTLPEEGEASISFWNQFETDCTITVMSGIHKRVLPHDKYLHEDKKNKSGIYNLFTTKSPAKGNGDWTLTYDLSYDGACGDTSKLEKTVKVTAKSKKIIYVGVGSFGYYQNTANTDKPTDGTGEFSMGIVTVFNSSYGGNFAMCRQNTSDFDVNHPCNPRHPADFYFWETDYNSHTDDRDQNATITGSLSSQPAVTYKQKSVKPGYWQLYYLLNTPKDVDRQTYNKTATLVAPTNYGFHRVKQGGVFIYALTGTYENPKIHELQIVQSNSVSILWQIPQIVVITAAEILFSITGYEFAYSQSAPSMKALVQALWLLTTAAGDSIIVVITILNLFENMAVEFFVYAAAMFVVIAIFALLSIFYYTYNYYTTDEEDGEIGVDDEEEIEDHNPRYSIDNKGFHPDEKDTFDMHF
The following text describes a protein:
Function:
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.
Domain:
Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.
Sequence:
MGVSDQFIELLQQQEELVANVPDTFAHTTCTVRMPQVLRDCVAKNGDRLSAEEGRRLLQLADDMANNAEIPLPSQFPEQAAKSPTSKHWESLLVGKSYTWQNSPWFLVEQYMFHLVLLLTDYYSTGFDPFHYSKVAELKGDTPWSLLQTAVEISAQEETTSQSHRNQLKRFMLLCLWGNKADGTNEKVKSTMHVAGDSLVFDDDLVLVDHSDQVISFLEQKARESGDAKSLGVEYINDNVGVELLLDLAMADHLLTHNWCGTVTLNVKAEPLYVSDVMPVDVDEHITEMQQSTRTPEVQALGKRLAEHVRKGQLLVRSDTYWNRYTYFWEMPTELQTRLAQEATLVILKGDLNYRRLLSDRLWPPSTPVEEVVPYFPTAFVAFRILKSIPVMGIPANIVAKLEKEEPHWRLNGQHGTIQSVLKPAAHSA
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MNPLISAASVVAAGLAVGLASTGPGVGQGTAAGQAVEGIARQPEAEGKTRGTSLLSPAFMEALTIYGLVVALAPLFANPFV
The following text describes a protein:
Function:
Toxic component of a type I toxin-antitoxin (TA) system. Upon overexpression inhibits growth and reduces colony-forming units in both the presence and absence of the Rac prophage, cells become filamentous. Has deoxyribonuclease activity (probably endonucleolytic), does not digest RNA. Its toxic effects are neutralized by sRNA antitoxin RalA, which is encoded in trans on the opposite DNA strand. Has RAL-like activity.
Miscellaneous:
MISCELLANEOUS: This protein is encoded on the Rac prophage.
Sequence:
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV