lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Promotes membrane protrusion and elongation on the peroxisomal surface.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MASLSGLASALESYRGRDRLIRVLGYCCQLVGGVLVEQCPARSEVGTRLLVVSTQLSHCRTILRLFDDLAMFVYTKQYGLGAQEEDAFVRCVSVLGNLADQLYYPCEHVAWAADARVLHVDSSRWWTLSTTLWALSLLLGVARSLWMLLKLRQRLRSPTAPFTSPLPRGKRRAMEAQMQSEALSLLSNLADLANAVHWLPRGVLWAGRFPPWLVGLMGTISSILSMYQAARAGGQAEATTP
The following text describes a protein:
Function:
May be involved in protein traffic between late Golgi and early endosomes.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MESADALVEEQKLMAEAKYRTYMTNIDKALRNFEYSSEWADLISALGKLSKAISSNTQYQVIPRRLKIAKRLAQCMHPALPSGVHLKALETYSVIFSKTGPERLATEFIYSAGLFPLLGYAAMNVRPALLAIYETYFVPLGDKLRPALSGFLNGVLPGYDCGLDHFERISALLKQVCNAVNPMHFYTVLWESVANNAAIRLPAITYLLEHFNKRLDMQEQIYIMGHNREIMMSALCVCLNDSLILVQRNTLEFLLLGFPMHTVLLSEDDLVKLVTNGLNTILRRDMSLNRRLFSWLLGSEVAKNSPTYDTLSLDTSNAPLEEEPEPYFVKHSRHILIKALITTLRLSLECAPMDLKPYRIMLSLLDKAEIGSAVLDYVLHDIIRAMYISSGNAEALKSANLLFATFDPAYIWSYMTNMFEKACQQANSMQEKSQAGETSGKYACDVGSGDPCVLEICVLTEFLLETVSLEMYTETTRVYLPKVFLAITQLLSLHMDHISSNEITASLKLCMKIVSRVQPMITSPIKLNKLIEQSGGSSSDEKITMNSASDAGKTEAGAQGNSLEKSKSDSRLNQFAENTLHSADPNDEELIHRSASNQSVGRQSPNKKKAKSISRLSELDKDISASDTGQQSSSDLDTPRSIKKLKAKAKVPFIRSPKKQRPKDMVLIQSNTSAEVSDGPSAEEPKSAPPDQTPQFQLDEESRATQQRGFSILEKCIRQYEIFFEVYLSRKLLHIESEPKECSVKVQLQRTTSTIHTSNLFMAEQVLDHECPVRESQIERLFNLLRVDIVPRSKQLQRLLNRSLPLPASASELSSDSEAQEEKQQSLLIDGQTQRSVQQLAELQLSPSLRGAVKLAATLLVEMSTFPNCNKHVVLDKNEPELPNWLKVLCLVACFAQSDKELQVASITTLFDLISLLRSQIEHTTSPGVTFVVMLPLLKFGHVSYMEQHTRVFQLVSSILWDYLGTAGIDPAQIAALLHQLHSCLESGLVETVIGNRMQSQHLLQMQSQSRSDLGKAAIRNFQMERLAEAQLLCPTESTERLRESQARSFKKFELLWHLGRDKQTARGFEKTLLKVLDTLALPHYMSERTFVTNWLQASLLRGDLARLTKPLYKILLSASSKRVGIVHMQQLYRESETEVTPAFERDVYAISSEQGNVKYHHMETSSGNKKKSPIRNFPKKIFGVTLSGGKANKVSNFVSDKSTVATCSEATQDMNTIGLIINPLENANDFDDETDLEEPRIEIPHKETPLEQKLASAMDESEQPSQEQPANQPDNSLQYDQDITDHSDSSDFESDSELRETSIEKEDSITVSSSAGVSDDVKRFVGDCESVTDALTQHEKIKSRKTYRLTREKTPGENSLNSLEQKDHDSISELQADALPADEYFREDKKLGKRKKVLTSGEKKRLSCISKTSTDSNISGSHVEQPEQEEETEPGTESTINVEDKRRNLSLETSKLQPDMQKTLEKGKQNVEILRQNNAAAAAAAAAAAEEQISVRSSMKSTVSLTDAAHLYHNHLLIYLAIYDTRQTLYALQTLRNIICCDKRTFLCLSITTSFSSASLKQLLVRHRKSISGKGFDGSVGNSEYAQGYRGCMQLELLVTLCLFYARGYFQKESLDAQRQSPTLQDIVNNRRIQLESIELLTLICSELIEIVKGMGRGLANYIADLLARAKLQKVMLHCLNSSVCSYGLKGNTNSGSYAEQVLSFNDPQDDQLHADCFQLQLLRLLLAVIRLEHEVHQLRQDTPPAAGEDSAGNASPTRLAEGATANVKYLPNCLISQQPMFLAAVLGALQQERLRHLHRNWTDLVTSSLNCFSFGSLTNIVISVVHQLCSNLDRISKMGLPQQRHFPPDYVVSQLEALTILCHYCLLDNTQQTALSHLFNQAYPQTSSSAQSSSTGQLLNSIVHSFLSASESSTSAPAPRNPQLQAARNAVLSHLPRIMSSVAAIWDSELGQLRPVRQQLLEFLSPVSLHHGSNFLAAVAVTWQQRGIATNMNGLSIAEQFQRNSVLQACPAQLSLVSLVSSIRVMPMDSFVMTLHHVVRSPPPIHRPPAQLSIEVSALELFYFYMKSAPAPQLADAWSSLLALIRDGLNLTPPAQFALLMLLNEFVQRCPQMPFQDKKEVRELHDVTSRLVDSLSSVAGSCLEQTTWLRRNLAVKEDTDGLAKDNSVGGGGLQQYSLQAQSVLAAILSNLLDVAYGSQEKDKVVNIVTPLLYNITPYLKNHTARNVPFFYACSALLASLSGYQYTRKAWRKDMLDLLLDNAFFQMHLSCLPFWRMIMDSLMTYDNTTFRELMTRVSLSQAGSLNIFTSRDQEYEQRAMLLKRLAFVIYCSEFDQHNKYMPDIQEQLANSLRLVPMGPSVQAAVFLCFRVLLLRMSPDHVTSLWPIIIAEMVQVFLQMEQELKSESEERNQQLRLPSGIDVSWSAASGASNGYNSQTPMQHWRSVQLEACKLLELGCVLPATKLPHFQMYRWAFVGTEFDVHEEEVCLPNGSLENLATLPSALYVPHVRRVARLMDMKYTSQSPILQRPSNRHLMLHFQQLQSLQELYAFFTTLGISCPQPRNFADTENDVANCLKEIEEVLANDFLEKLPSITTPR
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
Sequence:
MTKPSNKLEGFDFYHKGLGSSKYVVAPMVDQSEYAWRILSRRYGAQLCYTPMFHAKLFSEHHKYRKQVFSTGEFDRPLIVQFCANDPETLLSAAKLVEAQCDAIDLNLGCPQGIAKKGHYGSFLQDEWDLIASMVKAVHEHISVPITCKIRIFPDVKKTIEYALMLQNAGCQLLTVHGRLREQKGQLTGLADWDQIRQVKEALSIPVFANGNILYHDDVERCIKETGVDGVMTAEGNLYNPAIFSGKHLDACDVAQEVFECIMQIQPMYLNICKEYPGSSDVGSAKPHLFKMLHMW
The following text describes a protein:
Function:
Catalyzes the C6-oxidation step in brassinosteroids biosynthesis. May convert 6-deoxoteasterone (6-deoxoTE) to 3-dehydro-6-deoxoteasterone (6-deoxo3DT, 6-deoxo3DHT), and teasterone (TE) to 3-dehydroteasterone (3DT, 3-DHT). Involved in the elongation of leaf sheaths and stems.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MVSAAAGWAAPAFAVAAVVIWVVLCSELLRRRRRGAGSGKGDAAAAARLPPGSFGWPVVGETLEFVSCAYSPRPEAFVDKRRKLHGSAVFRSHLFGSATVVTADAEVSRFVLQSDARAFVPWYPRSLTELMGKSSILLINGALQRRVHGLVGAFFKSSHLKSQLTADMRRRLSPALSSFPDSSLLHVQHLAKSVVFEILVRGLIGLEAGEEMQQLKQQFQEFIVGLMSLPIKLPGTRLYRSLQAKKKMARLIQRIIREKRARRAAASPPRDAIDVLIGDGSDELTDELISDNMIDLMIPAEDSVPVLITLAVKFLSECPLALHQLEEENIQLKRRKTDMGETLQWTDYMSLSFTQHVITETLRLGNIIGGIMRKAVRDVEVKGHLIPKGWCVFVYFRSVHLDDTLYDEPYKFNPWRWKEKDMSNGSFTPFGGGQRLCPGLDLARLEASIFLHHLVTSFRWVAEEDHIVNFPTVRLKRGMPIRVTAKEDDD
The following text describes a protein:
Function:
Pyruvate dehydrogenase [NADP(+)] is one of three enzymes participating in respiratory metabolism. The enzyme is also active with 2-oxobutyrate and oxaloacetate. The enzyme is oxygen sensitive.
Miscellaneous:
MISCELLANEOUS: Arose from gene fusion of pyruvate:ferredoxin oxidoreductase and cytochrome-P450 reductase. Gene fusion has only been found in Euglena and Cryptosporidium; MISCELLANEOUS: Euglena cells absolutely require thiamine for growth due to the lack of a pyrimidine formation biosynthetic pathway. Thiamine is actively taken up into the cells and is used as a cofactor after being converted to TPP (thiamine pyrophosphate).
Subcellular Localization:
Mitochondrion.
Sequence:
MKQSVRPIISNVLRKEVALYSTIIGQDKGKEPTGRTYTSGPKPASHIEVPHHVTVPATDRTPNPDAQFFQSVDGSQATSHVAYALSDTAFIYPITPSSVMGELADVWMAQGRKNAFGQVVDVREMQSEAGAAGALHGALAAGAIATTFTASQGLLLMIPNMYKIAGELMPSVIHVAARELAGHALSIFGGHADVMAVRQTGWAMLCSHTVQQSHDMALISHVATLKSSIPFVHFFDGFRTSHEVNKIKMLPYAELKKLVPPGTMEQHWARSLNPMHPTIRGTNQSADIYFQNMESANQYYTDLAEVVQETMDEVAPYIGRHYKIFEYVGAPDAEEVTVLMGSGATTVNEAVDLLVKRGKKVGAVLVHLYRPWSTKAFEKVLPKTVKRIAALDRCKEVTALGEPLYLDVSATLNLFPERQNVKVIGGRYGLGSKDFIPEHALAIYANLASENPIQRFTVGITDDVTGTSVPFVNERVDTLPEGTRQCVFWGIGSDGTVGANRSAVRIIGDNSDLMVQAYFQFDAFKSGGVTSSHLRFGPKPITAQYLVTNADYIACHFQEYVKRFDMLDAIREGGTFVLNSRWTTEDMEKEIPADFRRNVAQKKVRFYNVDARKICDSFGLGKRINMLMQACFFKLSGVLPLAEAQRLLNESIVHEYGKKGGKVVEMNQAVVNAVFAGDLPQEVQVPAAWANAVDTSTRTPTGIEFVDKIMRPLMDFKGDQLPVSVMTPGGTFPVGTTQYAKRAIAAFIPQWIPANCTQCNYCSYVCPHATIRPFVLTDQEVQLAPESFVTRKAKGDYQGMNFRIQVAPEDCTGCQVCVETCPDDALEMTDAFTATPVQRTNWEFAIKVPNRGTMTDRYSLKGSQFQQPLLEFSGACEGCGETPYVKLLTQLFGERTVIANATGCSSIWGGTAGLAPYTTNAKGQGPAWGNSLFEDNAEFGFGIAVANAQKRSRVRDCILQAVEKKVADEGLTTLLAQWLQDWNTGDKTLKYQDQIIAGLAQQRSKDPLLEQIYGMKDMLPNISQWIIGGDGWANDIGFGGLDHVLASGQNLNVLVLDTEMYSNTGGQASKSTHMASVAKFALGGKRTNKKNLTEMAMSYGNVYVATVSHGNMAQCVKAFVEAESYDGPSLIVGYAPCIEHGLRAGMARMVQESEAAIATGYWPLYRFDPRLATEGKNPFQLDSKRIKGNLQEYLDRQNRYVNLKKNNPKGADLLKSQMADNITARFNRYRRMLEGPNTKAAAPSGNHVTILYGSETGNSEGLAKELATDFERREYSVAVQALDDIDVADLENMGFVVIAVSTCGQGQFPRNSQLFWRELQRDKPEGWLKNLKYTVFGLGDSTYYFYCHTAKQIDARLAALGAQRVVPIGFGDDGDEDMFHTGFNNWIPSVWNELKTKTPEEALFTPSIAVQLTPNATPQDFHFAKSTPVLSITGAERITPADHTRNFVTIRWKTDLSYQVGDSLGVFPENTRSVVEEFLQYYGLNPKDVITIENKGSRELPHCMAVGDLFTKVLDILGKPNNRFYKTLSYFAVDKAEKERLLKIAEMGPEYSNILSEMYHYADIFHMFPSARPTLQYLIEMIPNIKPRYYSISSAPIHTPGEVHSLVLIDTWITLSGKHRTGLTCTMLEHLQAGQVVDGCIHPTAMEFPDHEKPVVMCAMGSGLAPFVAFLRERSTLRKQGKKTGNMALYFGNRYEKTEFLMKEELKGHINDGLLTLRCAFSRDDPKKKVYVQDLIKMDEKMMYDYLVVQKGSMYCCGSRSFIKPVQESLKHCFMKAGGLTAEQAENEVIDMFTTGRYNIEAW
The following text describes a protein:
Function:
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
Miscellaneous:
MISCELLANEOUS: This protein is not predicted to have a signal sequence by the program SignalP. All other members of this family are periplasmic proteins.
Subcellular Localization:
Periplasm.
Sequence:
MEKKLKSWQGWLLSGGSMVVVFVLGLCVSALMERRAEVASIFNNRKTVIKGIEARNELFKDDFPREYQTWTETAKTDFESEFNGNVAVDALEKRPEMVILWAGYAFSKDYSTPRGHMHAIEDITASLRTGSPAGPHDGPQPSTCWTCKSPDVPRMMEALGVDSFYNNKWAAFGDEIVNPIGCSDCHDPETMNLHISRPALIEAFQRQGKDITKATPQEMRSLVCAQCHVEYYFKGDGKYLTFPWDKGFTVEDMEAYYDEAGFYDYIHKLSRTPILKAQHPDYEIAQMGIHGQRGVSCADCHMPYKSEGGVKFSDHHIQSPLAMIDRTCQTCHRESEETLRNNVYERQRKANEIRNRLEQELAKAHIEAKFAWDKGATEDQMKDVLALIRQAQWRWDFGVASHGGSFHAPQEIQRILSHGLDRAMQARLAVSKVLAKHGYTEDVPMPDISTKAKAQEYIGLDMDAERAAKEKFLKTTVPAWLEKAKANGRLAQK
The following text describes a protein:
Function:
Microtubule-associated protein (MAP) that regulates the orientation of interphase cortical microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAGEIQDPFSLSFQGNSIHSGSISFGRFEKEGLSWEKRSSFSHNRYLEEVDKCSKPGSVTEMKAHFEAHFKKKGIRFPASLESQTWGVHQTSNEPDDEAVHATESFEDYRSDGSFSEDTSQSNSVCNYSHEQEKCGQGKSQCEFDEESDHCVSYDEILVNSDEVIELDEEEGGGDHGRVADLVECENLGPPEMPQEIVIQDSALVEEAGSKLDEHASKKPSNSMETPSSSVNVKPIIPNDVRVTKASTKGHDVTPKAASRRTKGSSLSSNSKTNVDAKSQKELRPKKTIESQPKSSNKTETRPPIATNRCKTSTTSSKLEMSTGSTSFRFKCSERAEKRKEFYMKLEEKIHAKKTETNQVQAKTQQKAEAEIKQFRKSLNFKATPMPSFYNIGTRPVSHNKTEPSKVAQSRSRPATSASITNRAVTRVSYKHGFEEAEMVKVMVSNRKQSAAKDSDLQKGNLMAVEMKQQIGARRSRN
The following text describes a protein:
Function:
Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MHPEVSEPVADGGAEQDCAQKPVVEPGGELGAEPGAEESAGDHGNAGQGDRKEETNDPKETNAGPSDTAYQNEQNQSGDSRSDGCLANQRDDKEDRGPRMTKSFLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLECNGIQKIENLEAQTELRCLFLQVNLLHKIENLDPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLKECLKLCVLDLSHNKLSDPEILSVLESMPNLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYTAEKEERQQWESREQKKIRDSIEALAMLKQQAEERRRQKASQEKGELPPDNVENVDAGKEGKEEPGEDGERRQKMELFVKESFEAKDELFPEESSLLEELPADVKGETEGPEPGGAPPAEAPTPAAVGAAWEESMPQIVAPAGASDTELNGAGDVGTLSLETEVQHFIDDLPDLEDVDTGEPLEDPDKKMCFPKITAISGLSDDSDSELDRTSLPLLEDASTDTLSNIFAISKDTSRKTELPFLDIVKAAAEGDLGMQRGDTKSSHPLVQELDDHGPSEPPPTPTTCQRDTSPPCTEDGDSDLLSASPPGNGTEKDEAQPETEPKELAEPEELAEPGAGADREDIEFGLD
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYLFETLPNYMIFVYRSLGIIQFCPKNSHKIVKISPTVLYVCLQLYFLYTSVKFSSDYMTLGFTGLFHYLDLLSTVGTVLSMLTSLVMFRKRSKRLKTLLEQTDKIEIFQTNEKSRLSCIQILLFAGIVGLILLVPFSNSMIDLSFFYFIPLFINIFDHMFLCDILNFISSKFGSINHHLRHQIKTEDEDIKTNIRRVQELSFSHYNLVDLTKKITRLFEITTLAAMGMWFGYMVDGSYYTLHVLVHGSPSFWTDVGFNCMFGVLHFFWLCFVIDGFARTQNTANLAAIYLHDIWNKYLERGKLDRNVRYLQLISIRFYNTKVRFTAMDFFSLDWTFGHLMIAAVATYVVILIEIEI
The following text describes a protein:
Function:
Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAARKLQAEIERTLKKVSEGVEIFESIFEKISTASNQAQKEKFEGDLKKEIKKLQRYRDQIKSWASSNEIKDKRALLDNRKLIEQQMEKFKAMEKELKTKAYSQAGLNAASRIDPQEKEKEDLRQWIAEMTDELNVQIDMLEAELETLQIAVRKAKKGDSSKSDRVSKIDKIIERHKHHQTTLEIVLRMMDNGNLKLEEVASVQDDVAYYVESNQDPDFEEDEGIYEGLNLEEAEAYGFANEDEDEDDSDTDTPMVSPPLKEREITVKNHAKDRDADSEIKRKGSKNDHDVKVSSPSKLKATVLPVRATVKEDLAKGSMLKSIILPPRPAPTPVRSVTGTALVEAPAPLSQRYAAAAASTTIPDPHIKPFKAADTGKGIRQLTADVMVPAAANLTVAGSHQTSSLAVLATNVPTHTEEINGKQHSIHTTLPNENHPLAVQTLAQKGSPQSLTTVSPSRVTFNLANSQYTSTSTSMPPSLSPSSNRSLVATPLASETFSNDMLHRIALDQSAESSPPIMEAMDNHLPPILADLVASFDIAKERSQRTSNDAYFSRMVESSFQCLIDATDSAKSKAYTAKDPYPVPSYYPQTPLATFESNPLIFERFDVDTLFFIFYYRIGTYQQFLAARELKRQSWRFHKKYLTWFQRHEEPKTITDEFEQGTYVYFDYEESWCQRKKTDFRFEYKYLEDEVQLQ
The following text describes a protein:
Function:
Plasma membrane sugar-proton symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVHADGHNFPGSDPNPHMNKFAFGCAIVASIISIIFGYDTGVMSGAQIFIRDDLKINDTQIEVLAGILNLCALVGSLTAGKTSDVIGRRYTIALSAVIFLVGSVLMGYGPNYPVLMVGRCIAGVGVGFALMIAPVYSAEISSASHRGFLTSLPELCISLGILLGYVSNYCFGKLTLKLGWRLMLGIAAFPSLILAFGITRMPESPRWLVMQGRLEEAKKIMVLVSNTEEEAEERFRDILTAAEVDVTEIKEVGGGVKKKNHGKSVWRELVIKPRPAVRLILIAAVGIHFFEHATGIEAVVLYSPRIFKKAGVVSKDKLLLATVGVGLTKAFFIIIATFLLDKVGRRKLLLTSTGGMVFALTSLAVSLTMVQRFGRLAWALSLSIVSTYAFVAFFSIGLGPITWVYSSEIFPLRLRAQGASIGVAVNRIMNATVSMSFLSMTKAITTGGVFFVFAGIAVAAWWFFFFMLPETKGLPLEEMEKLFGGGGPRGDRDGLEIQTKTISIGGFS
The following text describes a protein:
Function:
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKHLAIYPGSFDPLTKGHLDILQRSLGLFDKVIIAIAVNSNKSTLFSIEERLGFIREVTKGMKGLEIDTFQGLTVDYCNKVGANSIIRGLRAVTDFDYEYAISLMNKKLAPNVETVFLMSSGEYSFISSTIVKEVARHGRDVSNQVPEIVSKALLKKLSQ
The following text describes a protein:
Function:
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
Subcellular Localization:
Cytoplasm.
Sequence:
MSINLVETRPKVTCEQAIHLSKNIYGVHVPSTSVSLVKELISYDDRNFYLQGFIQNEEQEPANLRGFLLKVSNPAFSKSQSILKGNSDLLLYLSKRDITCPVPYSSRNGDYKVLSKDEDNADGACAVRLFSYVSGSLLEKVALTEDVLYDLGASVASMHKAMKDFSNTYPSIHELSRDNFIWNIRNAPRVVNKLSHVFDCGVKLDLINTAMKRFQNILSKLDTIEKQIIHGDMNEKNILVQEKLDKNTFGFIDFNDFYFSNRVVDLGIALAYIMMLPQVNSHLTRPQAVGHMFAGYQSEWPLPKEEVEMLGAIAAARCSQSLVVGAYQHAYVHLDNEYLLVSQKGSWKALNSL
The following text describes a protein:
Function:
Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MATIYACRGFHRVPVKLSPSSTLQEVILSSYKQLGFSDWHNLELLHGDKKVDTSLLLRLSGIINGAKLIVKESATNQSGKSSSSISPQSKKIKVALQLPGAARIIDEASSETSIKQLLERHSLLTKVSHVLINGRNFKSEEFDNPLLLYGIREGSILIRLFPIKAQQSIVSEQAPVSQTFNGDVKEKKNADLMDIESENKKDDIVESFPKYPVDAHKLLEPLPTPIPSLPSTPSSYQNLPSQSLTGESLPTVSNQEKDEGVIEKVAVNNTPSVSSKSPFPKKKSFSSMLAQVKKEKAENNGSDGYDLQPTKSQLELYQSILRKRANQVSSTSLTKSSSPKPLPSSAIVKFDFGNGKSIVHEFSKDDNIETLRAFVASHLSPEESTSFQLTFSNYEALPTTGLIVEHIGRAVVRVHTISDPVYAQR
The following text describes a protein:
Function:
During interphase, forms fibers at the proximal ends of centrioles to maintain centrosome cohesion. During mitosis, dissociates from the centrosome following phosphorylation to allow centrosome separation. Contributes to CROCC/rootletin filament formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Concentrated at the proximal ends of centrioles where it forms fibers. Centrosomal localization becomes weak when cells enter prophase and is significantly decreased in metaphase.
Sequence:
MNLDSIHRLIEETQIFQMQQSSIKSRGDMVAPASPPRDTCNTCFPLHGLQSHAAHNFCAHSYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQKEALEAKVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQNW
The following text describes a protein:
Function:
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Sequence:
MNVAILLAAGKGERMSENVPKQFLEIEGRMLFEYPLSTFLKSEAIDGVVIVTRREWFEVVEKRVFHEKVLGIVEGGDTRSQSVRSALEFLEKFSPSYVLVHDSARPFLRKKHVSEVLRRARETGAATLALKNSDALVRVENDRIEYIPRKGVYRILTPQAFSYEILKKAHENGGEWADDTEPVQKLGVKIALVEGDPLCFKVTFKEDLELARIIAREWERIP
The following text describes a protein:
Function:
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly. PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MATQTVEDSSRSGPRSTTVGKLLKPLNSEYGKVAPGWGTTPLMGVAMALFAVFLSIILEIYNSSVLLDGISVN
The following text describes a protein:
Function:
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site (By similarity). Inserts the correct base with higher fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity.
Sequence:
MDFASVLGKSEAHQRTIIHLDMDYFYAQVEEIRDPTLRSKALGIQQKNIVVTCNYVARAKGVTKLMLIAEAQRICPDLVLVNGEDLAPYRQMSQRIFDLLLNYTPLVEKLGFDENFMDVTALVELRQAHVAEALLRPPVGHTYPADGTPLSNCDCGCAQRLAIGTRIAQEIREELKLRLGITCCAGIAYNKLLAKLVGSSHEPNQQTVLVSTYAEQFMRELGDLKRVTGIGQKTQCLLLEAGMSSVEQLQQCDMDVMRKKFGFETATRLRDLAFGRDTSLVRPSGKPKTIGMEDACKPISVRTDVEERFRMLLKRLVEQVAEDGRVPIAIKVVLRKFDSQKKSSHRETKQANILPSLFKTSMCPGETGVSKVQLADGAQDKLLKIVMRLFERIVDMSKPFNITLLGLAFSKFQERKVGSSSIANFLIKKADLEVQSITSLTNTSLTSPTAESPTSDECAFRSSPTTFKPSDQFYRRRATTASPVPMLLDNGSESAATNSDFSDFSETEVEPSPKKSRIGRLLVSKRSRLAADVGDSAAEVASPSKLRVCDLRLNSRDSEKDFPMSTTPSTSTSAPAPRFRTVQPPNTLLQRIDGSLRFVTTRTASRLSSNASSTASSPLPSPMDDSIAMSAPSTTTLPFPSPTTTAVVTSSSSTATCDALTNIVCPAGVDAEVFKELPVELQTELIASWRSSLVAAVEQTNGTGAATSAAIASGAPATATTASGQKNTLYRYFLRNK
The following text describes a protein:
Function:
Member of the two-component regulatory system MtrA/MtrB. Probably functions as a membrane-associated protein kinase that phosphorylates MtrA in response to environmental signals. Autophosphorylates and transfers phosphate to MtrA in vitro. Overexpression of MtrA alone decreases bacterial virulence in mouse infection; co-expression of MtrA and MtrB restores normal bacterial growth, suggesting that bacterial growth in macrophages requires an optimal ratio of MtrB to MtrA. Probably plays a role in cell division.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Found at the septa or mid-cell, independent of phosphorylation state.
Sequence:
MIFGSRRRIRGRRGRSGPMTRGLSALSRAVAVAWRRSLQLRVVALTLGLSLAVILALGFVLTSQVTNRVLDIKVRAAIDQIERARTTVSGIVNGEETRSLDSSLQLARNTLTSKTDPASGAGLAGAFDAVLMVPGDGPRAASTAGPVDQVPNALRGFVKAGQAAYQYATVQTEGFSGPALIIGTPTLSRVANLELYLIFPLASEQATITLVRGTMATGGLVLLVLLAGIALLVSRQVVVPVRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQIAQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADLIYDHSADLDPTLRRSTELMVSELDRFETLLNDLLEISRHDAGVAELSVEAVDLRTTVNNALGNVGHLAEEAGIELLVDLPAEQVIAEVDARRVERILRNLIANAIDHAEHKPVRIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISVEDARLHQGRLEAWGEPGEGACFRLTLPMVRGHKVTTSPLPMKPIPQPVLQPVAQPNPQPMPPEYKERQRPREHAEWSG
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MELQFLRATTGLTGMAVAKDPHVALRVLYTKTLAALEKLPKDAAYRQHTEGIINDRFDLVKTVSDVEELERKINCGQIEQVIIQAEAELSLARKMADWKAWEPLVSEPPEGQWKWP
The following text describes a protein:
Function:
Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. Has retained some ancestral activity toward nucleobases such as urate, an oxidized purine. Low-affinity high-capacity sodium:urate cotransporter, may regulate serum urate levels by serving as a renal urate re-absorber (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKAQEDPGSSKQHECPDSAGTSTRDQQAPLPAEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGRDQHMISQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKAILALERWKCPPEEEIYGNWSMPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALLSYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIVLFSQYLRNLTFLLPVYRWGKGLTLFRIQIFKMFPIVLAIMTVWLLCYVLTLTDVLPADPTVYGFQARTDARGDIMAISPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGVCCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLDSNPGAINTGVPEVDQILTVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSETLASLKSYDFPFGMGMVKRTTFFRYIPICPVFRGFSKTENQPAVLEDAPDNTETGSVCTKV
The following text describes a protein:
Function:
Seems to be associated with spermiogenesis but is not essential for sperm development and male fertility.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum.
Sequence:
MELSHRQGTTTLTRTHPNDKEGQQDMNSFRANHSSLDNSKFKYHARLSQSPLGSSLGQGYLETPPLPPTPTCRTSLAMNSHPEDLKKGASRSSSRDARETFREGCVGEEGQDSRSPEQRTVPLSKKDSVIPENIRHKFGSKMVDQLISEDQARQAIGEMFEGQKRPSSWPSRTQSPMQASSIFSDYYDLGYHMRSNLFQGPPQETKSLMKASYTPEVIEKSVRDVEHWHGRKTDDLGRWHRKNAMNMNLQKALEEKYGEKSRSKAK
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Sequence:
MFLLVLAPPTSSLRPALPRRPTLSGDNHPVEPLLSGNLTSPALASNIRANDLRLTVSIAQIYKPYVLLSTGKLSWQEEPLHFGGVVKRVRLYDASANVLREEFLHGGAVLDCCFHDDTSGFSASADNTVTRASDYRELVQNFEVLGPTWWRCTGAINVLDSNCNRTCSIGCFWTGYALSSVEGRVAMEGRRNICSQFQRKKREARKLQAQVRRRNQGQGVLQGTRFEMKITLQFKVTSPEAALVFLQAWNYSHVIYNHRAAWTPNVKVAAFGTGTTIFHEATPSSEQFIEVAFTPSKATGKVLASEPPKQGNERCTHGFHITRLNTYTTEPVQHMDQTILQQALSASVVAVASPSAVGAWVDLLPEPHTWEGSVACIGETTDSAARKLGLTNVYHPSTPGLHDLKYLFLCKNLRVDAYDH
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRLFSSRFYCKIATKSNEKATKLDFKQLTHPTKVPQTPVDSKFPDTSASEIQIDTKTIQLLERLSLVDLDSERALATLKSSIQFADKIAHINTEHVRPLYTVLEHQQLQLRNDQVTEGDCRAEVLRNAKVTDEDYFVSPPGNIPLEQ
The following text describes a protein:
Function:
The function of the small subunit is not yet clear.
Subcellular Localization:
Nucleus.
Sequence:
MEAMEVDSQTQLQRKQSAYLSLDENFEIQNEVYRGQQYSQIYFARLHMMRTLLYSLAPNWKSHLPVCTVLGLEEGKECIIVGTLYKHMKLKPCILDEYSKERSTAPLVKPHNFMHQDDYLFLEDESGRVKLGGTMLSPSVYVTGVVIALHGKETTAGDFFVEDVLEAGLPPQIERPLQSREDKYVVFVSGLTVGSGASNPLQFQLLVDHITGHLGDEEEQGLAADIVHLVIAGNSVEISRGLLNGQNLASKDQSRLSEPIKELDILLTQIAASLPLDIMPGSNDPANFSLPQQPLNRCLFPGSATYNTFRSCTNPHCFELDNIRFLGTSGQNINDLTEYSEAKDKIDFLERTLRWRHLAPTAPNTLGCYPFTDRDPFLIGSCPHVYFVGNQEKYETRLLKGSEGQLVRLICIPRFCETGVAVVLNMRNLECHALTFGTQFSS