lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes oxidative C-C coupling reaction to polymerize flaviolin and form highly conjugated pigments which protect the soil bacterium from deleterious effects of UV irradiation (three isomers of biflaviolin and one triflaviolin).
Miscellaneous:
MISCELLANEOUS: The structural studies suggest catalysis likely occurs through proton relay via a 'proton wire' formed by water molecules in the active site.
Sequence:
MTEETISQAVPPVRDWPAVDLPGSDFDPVLTELMREGPVTRISLPNGEGWAWLVTRHDDVRLVTNDPRFGREAVMDRQVTRLAPHFIPARGAVGFLDPPDHTRLRRSVAAAFTARGVERVRERSRGMLDELVDAMLRAGPPADLTEAVLSPFPIAVICELMGVPATDRHSMHTWTQLILSSSHGAEVSERAKNEMNAYFSDLIGLRSDSAGEDVTSLLGAAVGRDEITLSEAVGLAVLLQIGGEAVTNNSGQMFHLLLSRPELAERLRSEPEIRPRAIDELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFERSPNPHVSFGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPFKKGALIRGPEALPVTW
The following text describes a protein:
Function:
Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP.
Subcellular Localization:
Nucleus.
Sequence:
MDDEDLYDEFGNYIGDSLDSSDNDDDDENQDDLFAAAQPPSINDNEYSQDEEEEEDANGKSQLVKTTTTNSNDTALVKTNIDTNQAETIYIQSQTQSLSNQPIIQPNHEKTMKLEYSIDNNDPLTNNFPEVNYSRDYLISLLNQSPERIRNVSIIGDFQSGKTSLIDQLIMYIHPKINIKKYLDNHKLEIERELTIKSSPITLLLSDSKSRSQILNLIDTPGHVDFEDETLAALNITDGVVLIIDAVLGMTIQDQYLIDQVIKQRLSMIIIINKFDRLILELKLPIKDCYYKLVGIIDDINDYIKSITTTTTTTTTEKKKEYKYKYKFSPDLNNVLFASSKFGIIFSLKSFAKLYITKQNSLMNIDQFSKKLWGEIYYDPQNHKFTTTTTTTTSTTTTTINNNNNNSLKHSFISFILEPIYKIITYTITNEPTDKRLSKLLWENFRISLPKFEYKKDAENLLKSVFQTIFNNYESFVDSLIEMIPSPAKQQPNNSFSSSSSSSLSSVDTLARVTKLIESSDGKSFNALVRIYKGGLTMGDKIKIYGENYHEDKDDYKLEIIKKIYLPGGRYNFPINQASLGNIVLIDGIDSIIKKGSAIITNESTNDTKDIDKLSFVPPSPPKYTNNSVFKIAIEPEIPSELPILLEGLRKINKSYLSSIINVEENGEHIILTKGELSMDCILHDLRFFFCDDLEIKVSDPMVKFSETCIENGYIRTSTTTTTTTTTNEDKDKDKDSLLSMTIIVEPIIDYKFSHDIEIGKLKFDNIDIDSKQLIKILKTEYGWDSLAARSLWAIGPINDLQNPSILLNDTLNQHHQQDNNNIIESIKSSIISGFKWSINEGPLCGDPIRNVQFKIIDITTNNNNKTTTSDNNNNNNKLLLSPAQIIPLMRRACHNAITNAIPKLMEPIYQLNVICSYKAINVIKHLLLNKNPQQQQQQQQQQQQQQQQRRGEIDTVTPIPGTPLFSIKGYLPVIDSIGILTDIKLNTQGQAIGSLKFNYWEIVPDELSEEFIIKTRKRKGI
The following text describes a protein:
Function:
Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation.
Miscellaneous:
MISCELLANEOUS: Present with 38000 wall-bound molecules/cell in log phase YPD medium.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MRLSNLIASASLLSAATLAAPANHEHKDKRAVVTTTVQKQTTIIVNGAASTPVAALEENAVVNSAPAAATSTTSSAASVATAAASSSENNSQVSAAASPASSSAATSTQSSSSSQASSSSSSGEDVSSFASGVRGITYTPYESSGACKSASEVASDLAQLTDFPVIRLYGTDCNQVENVFKAKASNQKVFLGIYYVDQIQDGVNTIKSAVESYGSWDDVTTVSIGNELVNGNQATPSQVGQYIDSGRSALKAAGYTGPVVSVDTFIAVINNPELCDYSDYMAVNAHAYFDKNTVAQDSGKWLLEQIQRVWTACDGKKNVVITESGWPSKGETYGVAVPSKENQKDAVSAITSSCGADTFLFTAFNDYWKADGAYGVEKYWGILSNE
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
Sequence:
MHITLYRKYRPSSFSEVSGENEIVKSLKLSLKNKSMAHAYLFSGPRGVGKTTIARLIAKGVNCLNLKETGEPCNECKNCKAINEGRFSDLIEIDAASNRSIDEIRSLKEKINYQPVEGLKKVYIIDEAHMLTKEAFNALLKTLEEPPAHVMFILATTELEKILPTIISRCQRYDFKPLDLEEMKLGLEHILKEENLSMTDDVYPVIYENSSGSMRDSISILERLIVTANGEEIDLKIAEDTLGITPSSRIKIFLNKLLNENEYDIINELENLANESFDIELFFKDLAKYCKNSIVKKEIDIDKGLKIISTIYDVIGKFKFEDDKKLVGYVIVAEILSNTKQTVVKVVNTTQTNVNPPTSSTEEKPKDKEKVNIKLTISDVKNNWNSILAEANNKRFSYRAFLMGANPVRIEENNLYINYDKKYSFAKDLMETPEYSQEFTKIVKSFFNEDDLEIKYEVVGQKKEEENKNSEFFQKIENYFKGEN
The following text describes a protein:
Function:
ABC transporter; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (Probable). May be involved in the secretion of E-ascladiol to be converted to patulin by the secreted patulin synthase patE (Probable).
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MVDNYHSSLDVAKTPIQSDADAQKSEAETEGPSSKSSQIAAGESIADSVRNFLELRQGGIPDDTGVVFDKISAVGSGTGSQDAPTVTSAAQSAFGLLSPLQNRQRKQYSRPILSGFSGTINPGEMLLVLGKPGSGCTTFLKTLSGLWDEYKEIQGELTLGGHPLLDVMKQRPQDILFCAESDDHFPTLTVAETLRFATRARCGPQVSAREIDTMVTQLAKLVGLGNVLNTKVGDAKIRGVSGGERRRVSLAEALATCARLICLDNPTHGLDSSTAVEFMEMMREWTTQSRCVAAMSVYQASDAIVSYFDKVLIINSGRQIYYGPVRDAKAYFEDLGFECLSTTTVADFLNVMSADPDVRRAQENRENQVPRTAEEFERAFSASPIYQEMQKSVQVAKERFQTNPSPLVKTSAFALPIWHQIWYCAGRQFRIVTSDYSLWAVELATIVVQSLVLGTLFRNQQRTTSSLFIFASALFYSVLVPALQSMAEFGNGFAQRPLILKQKRYQISRPIAYALGLVTTDVVWKVAAICYNIPLYFLTGFQRTAGNFFTWFLIIYLEHLALSMFFRSVAIFSPNMHRAVLPVGIFFNMYVLYTGLYVPAPQMQVWLGWLRYLNPLYYAFESVMVNEFRDLSYQCSASDPVPSGLGYNDMAHQVCAVVGSEPGDRLLSGASYIHAQYGFKTSHLWRNVGINAALFVFFALCSGIGMEMLKTPAGQLATVFYKSSPGVTHRRDKIDSETGQDQGNESSEMSAGQSNDALRLQEHQGPDKSHNLAWTNLCLDIKTKEGDQRLLNNLSGSVKSGQLKALMGVSGAGKTTLLNALAGRSTIGNLTGTLALNGQVLPTFFRSRMGYVQQQDIHLPTQTVREALQMTARLRRPESISVADKNAYVEKVIEWLSMEHIADALVGVPGAGLNLEQRKKVSIGVEMASKPEILFLDEPTSGLDGQSAMLIARLLRRLADSGQAILCTIHQPAAELIDQFDKLYLLSRGGNLVYDGSLGTRCHEAIQYFQPRSRPCGPEENPAEYFLAVIGAGSRNDAHMDWASLWNDSEQGKEREKAEESLVPAAEQAPQLEQQSLYSVPFHVQLWVVVQRTWLYYWREPDYVNSKLWMSVGNSLLNSLTHLQSPNTERGAYNRVFSAFMSLIVGPPLGLQVQPRFVTLRDIFVHRERESLTYHWLAFVLSAFIVELPFTFLSSLVYWLLWYFPVGYFNAPSRAGYSFLMYELFGVFATSLAQLCASLMPNIEAAFAANGFFFMFCNTFAGTLSPKPVTPSGWRWFYNISPLFYLGEGVTVDVLQDLPIRCEESEVSIFYAVNGTTCGQYAQDFLKTATGYLLNPASTTECQYCRYRDGQSYFQQYGYEFAHRHRNIGVFICFIAFNFTMVLVMTYLTKTRRH
The following text describes a protein:
Function:
This enzyme recycles the H(2) produced by nitrogenase to increase the production of ATP and to protect nitrogenase against inhibition or damage by O(2) under carbon- or phosphate-limited conditions.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MAVQTPNGFNLDRSGKRIVIDPLTRIEGHLRIEANLDSDNVIRNAVSSGTIWRGIEVILRGRDPRDAWAFTERICGVCTGTHALTSVRAVENALGITIPENANSIRNIMQLCLLVHDHLVHFYHLHSLDWVDVVSALKDDPKSTSTLAQSISPWPLSSPGYFKDLQIRLGKFFGSGQLGPFKNGYWGHPAYKLPPEANLIAVAHYLEALDFQKEIVKTQAIYGGKNPHPNWLVGGVPCAINIDGIGAVGAIGMERLNIISSIIDRSIEFVEQVYLPDIAAIFSYYKDWLHGGGLSSKSVMSYGDIPEKANDCSGESFKLPRGVILDGNLKEILPIDHGDPEQIQEFVAHSWYKYPGHCCGLLPWDGITEPSFELGPKLKGSKTDIKELDEGGKYSWIKAPRWRGRAVEVGPLARYIIGYAQGKAEFKEPAERLLKGLNLPVTALFSTLGRTAARALECQWAAHQMRHFQDKLVINIKAGNTATADISRWRPETWRKEAKGYGFTEAPRGALGHWITIKDAKIDNYQCVVPTTWNGSPRDSSGNIGAFEASLIGTPMADPQRPLEILRTIHSFDPCLACSTHVMSHEGQEMASIRVR
The following text describes a protein:
Function:
Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Required for processing ITS2 sequences from rRNA intermediates during 26S rRNA maturation. Required in the soma to promote normal proliferation and prevent germline tumor formation.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MADSVQPSELLLAGCSSSDLFSTLLIDPKTGVSSWYHKGSELQGGSLGKVLPLGQNGDHLLLSMKDRPFLHVIGVNAHERFHQRSSVCGMVRDLAVTSDGSLLFVAIDKRIFVWLLSNGDLVGVRDVHLRNVTYISLSIDDSTLVTTSEDGAVRVFLVSDLISSQESESSPFREWQAHSLSVTGLSLSRCGSLRVASCSLDHTASIHSVALDICLLRVSADRPFTSICLCPSETRLVMGTDKGVVACVSLYDAAKNDQKEITLSTTNSASTDFLLRGKHTSEVVRLCFNSDGTLLASGDSEGKYIIWQIGSKQVLKESTMHGAVCTLQFVPYWRSVLGREDKNIHRPNLNLNRTIGERKQLSLLRSQQIDSDEYWMGVIDKLLNESGETKKNTIVKREKEEEEVYKDEIIKKLTAEKNKLMKINKELYDYTTSEVFNINT
The following text describes a protein:
Function:
Involved in glutathione-independent cadmium resistance. Reduces cadmium uptake rather than activating efflux, but is not closely coupled to calcium transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
the N-terminal domain (1-84) is required for cadmium resistance.
Sequence:
MEAQLHAKPHAQGEWSTGFCDCFSDCRNCCITLCCPCITFGQVAEIVDRGSKSCCAAGALYMLIDLITSCGRMYACFYSGKMRAQYNIKGDGCTDCLKHFCCNLCALTQQYRELKHRGFDMSLGWAGNAEKQQNQGGVAMGAPAFQGGMTR
The following text describes a protein:
Function:
Catalyzes the attachment of arginine to tRNA(Arg) in a two-step reaction: arginine is first activated by ATP to form Arg-AMP and then transferred to the acceptor end of tRNA(Arg).
Sequence:
MAWHFRRVIAEQVARVLGLPSERVAHCIRTVPVHRKHESPDFQLFMTSLGDPIDTSINHEERAQQLAGKLVCDSVISDIGTARASVTFKINRDLLTRTVLQQISKDGSIYGLNTELFSGLSGRKTVVEYSSPNIAKKFHVGHLRSTIIGNFIANLKQAVGNEVIRINYLGDWGLQFGLLGAGFSKFGSEEELVVNPLQHLFEVYVKVNTAAEEDKDIKLSAQEFLRRLEGGDPHALSLWMHFRDLSIQEYAKVYKRLGAHFDDYSGESFYKEKSQEVLKQLESNGLLQKTDKGTGVVDLSEEGNLSSYSTVMRSDGTSLYITRDVAAALDRLERYSFDEMIYVTDKSQKNHFQQLFKILKILGKDQADRFQHVPFGLVKGMKTRRGEVVFLEDVLDEARSRMLQNMAASGTSKQLEDPSDTAEKIGIAALIVQDFKGQLLSDYHFDWDQALQSTGDTGVFLQYTHARLHSLQALWCSRDTDDIDIASLREPCVIATLQHLLRYDEVIYKCLEDLQPRYLVTYLMSLGHLANVAHRALHVKRSSSEAAHARLFFFNNVRMVLSSGMKLLGISPVNNM
The following text describes a protein:
Function:
Involved in protein degradation through the ubiquitin/proteasome pathway.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MSGSRKQEAIDELRNSLDVPADTAQSVLESFNWDVQEAIESLTGESSRVDRNSKLGLSFGVFQSVFSLLFSGLHKLWMILSRVPLISTFIPIFGTTKRVLSPADTANKLVQNLEEQYGTEHIDFFTDGGYMEALTRIKRNYGVALLFFTSSKNDDSETFSRSVLMNQELKEFLNRRNILCWTGDVCEDEAFRGSRQFHCTKFPSAVLVMYSPQLSELVVAAQLHGCLDSSSIITNLTNALAKHLPSLERFRSEREAREAARELRRQQDNAYQASLARDRERQAFARAEEERLAKEKEEREIVQKKKKQYRAWLASNLPPEPSSEDEPARLSIRFPDGSRAVRRFKKDDTVESVYNYVDYMLFEKEEPEEFGRATSSSNPVTPPSDYKHDFHFQLYSSLPRALLKPSVAISTNKAIFPNGTVVVELDD
The following text describes a protein:
Function:
Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses. Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A. Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation. Negatively regulates apoptosis through interaction with PTMA. Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter. Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2. Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation. Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion. Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity).
Miscellaneous:
MISCELLANEOUS: Mediates resistance to anticancer drugs, namely taxol, doxorubicin, gemcitabine.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, perinuclear region.
Sequence:
MATFPPATSAPQQPPGPEDEDSSLDESDLYSLAHSYLGGGGRKGRTKREAAANTNRPSPGGHERKLVTKLQNSERKKRGARR
The following text describes a protein:
Function:
Has a role in the Wnt signaling pathway controlling the asymmetry of cell divisions during embryogenesis. Operates in the AB and EMS cell lineages influencing cell specification. Required for body wall muscle development, endoderm development, pop-1 asymmetry and T-cell division asymmetry. Component of the beta-catenin-lit-1 complex which promotes the phosphorylation, down-regulation and subcellular relocation of pop-1. Regulates plp-1 nuclear localization in embryos. Plays a role in male tail tip morphogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPNVFQSLVSSKRVFRELKMLCFFKHDNVLSALDILQPPHIDFFQEIYVITELMQSDLHKIIVSPQHLSTDHIKVFLYQILRGLKYLHSARILHRDIKPGNLLVNSNCLLKICDFGLARVEEADANKAMTQEVVTQYYRAPEILMGARHYSSAVDVWSIGCIFGELLGRRILFQAQTPIQQLELITDLLGTPNVEDMSSACEAARKHMIRRPAKPASLAALYTLSSQATHEAVHLLSQMLVFNPEKRINVIDALAHPYLDEGRLRFHSCMCRCCQTASQPGSVAVRRYASDLEPSAVQPFEDHWERELTSTHQVREKLHKFIMDQLMSSQVPLCINPASAAYKSFASSTVAHPSELPPSPHNWE
The following text describes a protein:
Function:
May promote appropriate targeting of ribosome-nascent polypeptide complexes.
Sequence:
MVNKNGNIRVWDLTANSCSCELCKQSKSEKKSRKAMFKLGMKPILGVGRVTVKKSKNMLFVISKPDVFKSPCFRHICNIRRSKNRGSELTVAESGSRAIQST
The following text describes a protein:
Function:
Probably a queuosine precursor-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKSKTYDIVTIAIVAALYVILTMTPGLSAISYGPIQFRVSEMLNFTAFFNKKYIIAVTIGCMISNFLSFTWVDVIVGGLSTLVFLSLGVLLFDRFKEDYFWNGQLNKAFFFFAIFFSISMFTIALELKFVAETPFLLTWGTLALGEFASLFIGAFIMDKLGKRVDLSR
The following text describes a protein:
Function:
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
Subcellular Localization:
Nucleus.
Sequence:
MSLPLSEQGVLTVVPDKLKQLAKYIMHGFYSVEHALVVDMLVRNTIMKEDDLADLLKFDKKQLRTLLMKIKNDKLLKQVMRVETQADGRAMRHYYYYINYKTFVNVVRFKLDRMRQKIENRERDSTCKALFKCTECTRTYNEFDAGNLYDPITMAMKCTYCGAEVQEDESAVPKRDAVTQMVTFNEQMKPMFDLLKDVEHVKLSQQLLEPTPVPLSDAQRGLLGNRGLNVGGPQRGWREGDRGPAELYHQDVTINIGENQGPATDQPAPRERPVWMTDSTVEGAITEAAPSGSGVETMEAERAGTKAGKSHEGEIMKALLAHERKVGQRPSFHHEHEPNSDNESDASASDDEYSQPQGRTEPPLSEDRLAFGTMMGDVTMGRHEEEEEEEEDMIVMVQGRPVPLDEVTPEMISEMDQEEKDEYIRLAQQAHADMYE
The following text describes a protein:
Function:
In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
Subcellular Localization:
Nucleus.
Sequence:
MVNAIKGLFISCDIPMAQFIVNMNASMPASEKFIMHILDPTHMFIQPNMGDYIKSKMAEFRDQNSYEKPT
The following text describes a protein:
Function:
Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTQDDVTTGLRTVQQGLEALREEHSAISNTLETNVKDVKEDEAPLPKQKLIQIDDNLDKLMCGVDETSMMLMAFQLTQGMDAQHQMYQAQRSRLCQENEWLLDELKSFQIKLQQSERMVAQLEEENKHLKYMASIKQFDDGAQADTKTVVNSGPQPVTSETLQELGFGPEDEEDLNTSQFAQPTPAPSMASAVVGYEIPARLRTIHNLVIQYASEGRYEVAVPLCKQSLEDLENTIGHAHPDVATMLNILALVYRDQNKYKEAANLLNEALSIREKCLGETKTWKNQGKYDETEKYYKRALEIYESKLGPNQPEVTKTKNNLSSAYLKQGKYKEAEDLYKQILNQAHEKEYGQVSGDNKTICQIVASALKKLGDLYRRQGKYEAAETLEDVAFRAKKQHEPLRSAALGGVDEMSHECTRIQFLNLAQRTELIVLVLPREKLFQIKAFLFFIFSVVMCMIFHFSIDFLFLVF
The following text describes a protein:
Function:
Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
Sequence:
MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEAVRAAGMVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCDKITPGMMMAALRINIPTVFVSGGPMAAGKTSKGEVVDLSSVFEGVGAYQSGKISEEELKDIEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKQAAEKLKILIERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAQEAGLDYDMNRIDAVSRRVPHLCKVSPASNWHMEDIDRAGGISAILKEMSRKEGVLHLDRITATGQTLRENIAEAEIKDKEVIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVKRFEGPCVIFNSQDEALAGIMLGKVKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGAEVALLTDGRFSGASRGISVGHISPEAAAGGMIALLEQGDIVCIDVEERLLEVRVSDEELEKRKKEWKRPEPKVKTGWLGRYAQMVTSANTGAVLKIPHFD
The following text describes a protein:
Function:
Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Sequence:
MRPWWCETGGPVFSRAPKEKTEQREQRGGDTTASRLTAAMAMRQLARLQQHLSPSLLCRHTPRHAWPPTADASFLCRGLASSSSSAAAAAAGREKSSRRTLGYLLGVAVAMVGASYAAVPLYRRFCQATGYGGTVQRRESVEEKISRHARDGTTTAREIIVQFNADVADGMPWKFIPTQREVRVKPGESALAFYTAENRSSAPITGVSTYNVAPMKAAIYFNKIQCFCFEEQTLLPGEQIDMPVFFYIDPEFETDPKMEGVNNIVLSYTFFKVNDS
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released, although no anti-sigma factor is known for this protein (By similarity). Regulates the promoter of SigI, may not be autoregulated.
Domain:
The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA, and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. The sigma-70 factor domain-2 mediates interaction with the RNA polymerase subunits RpoB and RpoC (By similarity); The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA. Interactions between sigma-70 factor domain-4 and anti-sigma factors prevents interaction of sigma factors with the RNA polymerase catalytic core (By similarity).
Sequence:
MEVSEFEALRQHLMSVAYRLTGTVADAEDIVQEAWLRWDSPDTVIADPRAWLTTVVSRLGLDKLRSAAHRRETYTGTWLPEPVVTGLDATDPLAAVVAAEDARFAAMVVLERLRPDQRVAFVLHDGFAVPFAEVAEVLGTSEAAARQLASRARKAVTAQPALISGDPDPAHNEVVGRLMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPTAVRAVRGSDKVVRFILGLVQRYGPGLFGANQLALVNGELGAYTAGLPGVDGYRAMAPRITAITVRDGKVCALWDIANPDKFTGSPLKERRAQPTGRGRHHRN
The following text describes a protein:
Function:
Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
Sequence:
MANRVVFEEAGTLKAIVEAVESLVGEASVKLDPDFGFGLQALDPSKTAMIQVSLPRAYFIEFEAESSRFYGIDFTDLAKMLKRVKNKERVELTFTESLMKITSMNGYRRVFEFPLLAGTPFEFKTIKVDFKARARLDSDTIPNVIKDLKIVGSDVEIYIDSEKVEFRTNSDRGKAVISITKEDRALIDIWAEEPSKSLYNMAYLEKMTKPADISEEADIELRTNAPLKLSYPVGGIEGAGITYYLAHLQV
The following text describes a protein:
Function:
TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. Participates in the interconnection of tauA with tauB via its contacts with TFC3 and TFC6. Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability.
Miscellaneous:
MISCELLANEOUS: Present with 15800 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MPVEEPLATLSSIPDSSADQAPPLIADEFTLDLPRIPSLELPLNVSTKHSSIQKAIKMCGGIEKVKEAFKEHGPIESQHGLQLYLNDDTDSDGSKSYFNEHPVIGKRVPFRDESVILKVTMPKGTLSKNNNSVKDSIKSLKDSNKLRVTPVSIVDNTIKFREMSDFQIKLDNVPSAREFKSSFGSLEWNNFKSFVNSVPDNDSQPQENIGNLILDRSVKIPSTDFQLPPPPKLSMVGFPLLYKYKANPFAKKKKNGVTEVKGTYIKNYQLFVHDLSDKTVIPSQAHEQVLYDFEVAKKTKVYPGTKSDSKFYESLEECLKILRELFARRPIWVKRHLDGIVPKKIHHTMKIALALISYRFTMGPWRNTYIKFGIDPRSSVEYAQYQTEYFKIERKLLSSPIVKKNVPKPPPLVFESDTPGGIDSRFKFDGKRIPWYLMLQIDLLIGEPNIAEVFHNVEYLDKANELTGWFKELDLVKIRRIVKYELGCMVQGNYEYNKYKLKYFKTMLFVKESMVPENKNSEEGMGVNTNKDADGDINMDAGSQMSSNAIEEDKGIAAGDDFDDNGAITEEPDDAALENEEMDTDQNLKVPASIDDDVDDVDADEEEQESFDVKTASFQDIINKIAKLDPKTAETMKSELKGFVDEVDL
The following text describes a protein:
Function:
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MKFLPDVAMFSEIRQMNIRQLFYQCLNFAMVVSSALMIWKGMMVITGSDSPVVVVLSGSMEPAFYRGDLLLLTNDLEDPVRVGDITVFKVEGREIPIVHRVIKVHEKSADNTKILTKGDNNQVDDRGLYAPGQLWLSRTDVVGRTKGLLPYVGMVTIIMNDYPKLKYAVLAFLGLFVLLHKEN
The following text describes a protein:
Function:
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested; [Orexin-A]: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity); [Orexin-B]: Binds to orexin receptor HCRTR2/OX2R only (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity).
Subcellular Localization:
Rough endoplasmic reticulum. Cytoplasmic vesicle. Synapse. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.
Sequence:
MNPPSTKVPWAAVTLLLLLLLPPALLSPGAAAQPLPDCCRQKTCSCRLYELLHGAGNHAAGILTLGKRRPGPPGLQGRLQRLLQASGNHAAGILTMGRRAGAEPAPRPCPGRRCPVVAVPSAAPGGRSGV
The following text describes a protein:
Function:
Probable transcription factor that acts with partial redundancy with HULK2 and HULK3. Plays diverse and essential roles in the control of plant development, physiology and flowering time.
Subcellular Localization:
Nucleus.
Sequence:
MAPGRKRGANKAMAIGEMRLGDLVLAKVKGFPAWPAKIGQPEDWNQAPDPKKHFVQFYGTGEIGFVTPPDIQPFTSETKKKLSARCQGKTVKYFSQAVEEISAAFEESQKQKSDIVGNEALLNAVEPSVTKPKYLNQASSDGKSDKFSSRADPCLGKLVENNGAEINPDVGEQDSSISNNRNTSPSSEPVEHGSPDPILKVAVDDKIDNVTCTDHSDGTGNNLVNDQRIIRKTTDDSNKRCKDEVRAKRVPDSRAATDNHILGPNQKLKGSIKGQDHGSKKGQDHGCRKESSDSKVVTDLNIASSKKPKELLKEKKKRFENELGKSASGADESKRAAKRPRSEDAKDQKQCKSKRLVPVGEGKAEISDSTGVVSIFKREIVLGISALGGKNQFDKDMVAYTKRRKQTVEHTSVSSFPGSLVKEGANHPEQKISSSSDSDIKVQAAQLPKRRRAVCIYDDDDDDEDPKTPVHGGLSNIPIASTDAPKSANASHNTSIKAKLLAGSTDSVKTGKVPLYKHNKDASLALPDSVEGYNSRMGKPFKALLQKNIKPILRSPKNSYQLVSFKKQVTGQNKTAKVAGAGMPDSVEGPSNSSYMGKPVIKLPPQNVKQTLRSPKKSPQLFSTKELVAVQNKIAKVSGAGIPKKYHGDSSKDVVAGSDRVSSSHSQTANQRSKPAFGEKPTSTPKVATRLDVEVSRDTFVNLSADVIDVNQENGNAPLFSFGMSDSSSSCMKDLIAAAQAKRKQAHSQFSPFVNLDHNSLNIDSMQTSKSPFMVQNVSSPAADATLIVAQEHQEVLTPSNHGRQSSSSNQAGTEENEERRFSSGHRSVGGSLSGATEAAISRDTFEGMIETLSRTKESIRRATRVAIDCAKYGIANEVVELLIRKLEIEPHFPRKVDLFFLLDSIIQSSHSQKGRARSLYIPTVQAALPRLLGAAAPPGTGARENRHQCRKVLRLWLKRKIFPDFLLRRYIGDLGASGDDKTVGFSLRRPSRSERAVDDPLRDMEGMLVDEYGSNANFQLPGYLASLTFGDDEEEDLPSTSQEVKNTHMEVKITHMEEPVLALGKLEAHDSSSDKPHCVVDVNGGLEMEDASCQLKDDVCGIEAKEDSPATTCATELPSFPAGSPPLPHESPPSPPPQPPSSPPPPSSPPQLAPAPPPSDHCLPPPTAPLAPAQSIALPPSSITRPSMPSHPSLPLQPGFAPPAYPLLQHEYQISMQRDHSSIATSNQIAPVPVNAAHGRHADGGVKSEYLMPQSSSFAPVGMCSYGEPLPFISSKQLEYGNSDVLFKQEASSQNQQLRPINTSFLQRPMIRNLAPAPSSHFPLPCRIVQSEPQRSSFPHPYHFPSQPVDGRQHMNEEWRMPPNGCSADPQYGAWIGVRNPFPGSRTVTDGVFQPPPERPPSGTVRYQLAANNLQGGSTISGNIASQMLLSRPDVPSAAQYRPS