lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Has phosphatase activity toward PtdIns(4,5)P2 and at a lower extent toward PtdIns(3,4,5)P3 but not toward Ins(1,4,5)P3. Functions in salt stress response by regulating reactive oxygen species (ROS) production, endocytosis, Ca(2+) influx and stress-responsive genes expression.
Sequence:
MWPRLVANKILRKSLGSNNFVADFPPNTDQKLIEASGLADERSKSILHNQHKTTLLNYKVFVSTWNVGGIVPDDGLDMEDLLETHKTPCDIYVLGFQEVVPLRASNVLGSDNNKVSTKWNSLIRDALNKRARPHRDEDLSESKGINGISQDFRCIISKQMVGILITVWVRGDLWPYIRYPSVSCVGCGIMGCLGNKGSVSVRFQLHETTFCFVCSHLASGGRDRDERQRNSDVNEILARSSFPRGSSLDLPKKILDHDRVIFLGDLNYRISLPEEKTRLLVESKKWNILLENDQLRMEIMNGQIFRGWQEGIVKFAPTYKYVPNSDLYYGCITYKKDEKKRAPAWCDRIIWYGNGLKQHEYTRGETKISDHRPVKAIFTTEITVTRRGKKIRNFFFSDRFEERIGDIDSKDYSWIST
The following text describes a protein:
Function:
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Sequence:
MILMNNPGDKEVLRLLKQRMESVSQVEETVKEIIRRVKEEGDRALEEFLKRFEKHPVGIENLRVTEKEISEAQVEEEFVETIKIVIEDLKEFHRRQEERSFFFTTKGGSFLGEMVVPLESVGIYVPGGKVPYFSTLLMCAVPAIVAGVERIAVTTPPNENGGISPYILKTCEILGLKEIYRMGGAHAVAALTYGTETVKPVDKIVGPGGVFVTLAKKHVYGDVGIDSIAGPSEIAIVTDGSADLDLIAADFLSQAEHDENAMSVVITTSKEVFEKLPQVIERHLEALPEERRKTARISTENFGTIILTDSLKRAFEISNLIAPEHLEVLVENPFEPLGHIKNAGSVFLGKYTCESVGDYGAGPNHVLPTFRSARFSSGLRVSDFTKKIFITHLSEEDFRRKSELYSKMARWEGFEAHARAIDVRREKL
The following text describes a protein:
Function:
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Membrane.
Sequence:
MTTEPKSTSPEVPAKFNPRQFLTEVRGELDKVVWPDRKQLISQSVSVVLIVVVIASFIYLLDELLKWLSGLIF
The following text describes a protein:
Function:
Regulates independently canonical Wnt and Notch signaling by modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal transcription factor in the Wnt signaling cascade, by blocking its ubiquitination. Involved in angiogenesis; involved in intersegmental vessel patterning during development.
Sequence:
MSQADVSTCSAPQRVFQEAVKKGNTKELHSLLQNMTNCEFNVNSFGPEGQTALHQSVIDGNLELVKLLVKFGADIRLANREGWSALHIAAFGGHQDIVLYLITKAKYSSGAR
The following text describes a protein:
Function:
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
Subcellular Localization:
[Phosphatidylserine decarboxylase 1 alpha chain]: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain; [Phosphatidylserine decarboxylase 1 beta chain]: Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Sequence:
MKFRYSNKLPIFAHSLRLSHQHHQRRQFFTSLLKRVQTASQVRASFNGSSGNPRGNIFLVPGATVATLLMLGALHARRLYDDKKVEEAREKGIEFEFQPDHKASFLRMLPLRSISRLFGSLTSVELPVWMRPHVYRAWARAFHSNLEEVALPLENYASLREFFVRTLKEGSRPIDPDPHCLVSPVDGTVLRFGELKGSGTMIEQVKGFSYSVSSLLGASSLLPVITEGDMHKESSEQQGNLKEKNKKSWWRFSLASPKIRDTVSACPAKGLYYCVIYLSPGDYHLIHSPADWNVLVRRHFSGHLFPVNERATRTIRNLYVQNERVVLEGLWEGGFMAIAAIGATNIGSIKLFIEPELQTNQRRQKILNSEPPDERVYALEGVGKSLKKGAEVAAFNLGSTVVLVFQAPTLKMLQNRDSSSEFRFSIRRGDRVRVGEALGRWHDL
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLPLLIAMAVVEAVVAYCLVSKVTPLVKLGQNVVDVFRSNKGARVVLKTVTGVVAVRLANDLSTVMKLHRQMEISGAHIAEQLESRSQWLEITLICFVLILKLVVSSLDLSFKRADGLKRDVDVLKGKLKGAEAEYVRLQDELSSKSDKECEALAAEVKSQKGIITTLRQKLEQAQVHINSKEKELKSVVTNLKTLEKQTEGFQNEYTRVLDDNENLRIQLSQFDRHHSSSGSKKNS
The following text describes a protein:
Function:
Has antibacterial activity against a wide spectrum of Gram-positive and Gram-negative bacteria including nosocomial isolates of S.aureus and Pseudomonas sp. The antimicrobial activity is due to hydrogen peroxide generated by its lysine oxidase activity. Also has autotoxic activity. Involved in biofilm differentiation; responsible for cell death within microcolonies during biofilm development which is linked to the generation of a phenotypically diverse dispersal population and thus may play a role in colonization.
Miscellaneous:
MISCELLANEOUS: The intracellular stability of LodA is dependent on the presence of LodB protein.
Subcellular Localization:
Secreted.
Sequence:
MALSVHPSIGVARLGNANTDNFVLNPMEIGGLPYEHDVDLKPTTTVVNFKDEAGCIRRQGQVFKVFGASNEELTLDSPNVKNIEWTVHLANKKAAWYEFRELNGNLLYGRDNSYSARGVPWRNASKTASSERQSLIIDLGPRSVSGVMATVEISINNIPETYLHPSYPSGELLQGSKHFESLGTLRTDSQGRLIVLGGYGFAGGNTDLSGYGGGDDWYDDISDGSVTCVVTYSDDSSETSTAWMVVGSPDFAPEIVNISTLSDTCFDVGVRNFDLVPDMYDSATGHYKSDYVANFDRDILPIIQRISQYQWVSNVQSMSGFFSFQFDYRDGSAANKANRMKYYNYFRQLDNKVIGDYDQPQQVLMSSEVEGDILPLMPMNSGSNSVSSSNFYDLTDNVVEKFLALDATQLFLLGQWAEGEFTAGPADDYPVSDMDTASIGNCVGLPMCPGIEMTWSLQNPVIYKDAYQIKHYQDKAYFDVNGLTPERDECEEETGCEPGDLTKRMACPWQADFFNCTIQTVNFSEPSVNKASQTETVTSRTHYEWGNLPAGVSVPDQSSVSATKNVDEKVPLPPAYYSYWWPPQSPWDVLTGELDTEGQLHSHLPAGQQINYARGINSYSQMVEHWSALAFIRDRNQNNDGFPFFTETERNHELFDFKEVLVGQVTGNSEDNETSLPVFFINANKESLEGKGTKKGKLMASYFEERAFSKVRSSNIRPRSGTRMRG
The following text describes a protein:
Function:
May act as receptor for class I MHC antigens.
Sequence:
MTRRTQPPIGHTLCVSSCQHQGLIHPQSRAVGGDAMTPILMVLICLGLSLGPRTHVQAGSLPKPTLWAEPGSVITQGSPVTLRCQGGQETQEYRLYREKKTASWITRIPQELVKKGQFPIPPITWEDAGRYRCYYGSHTAGRSENSDPLELVVTGAYSKPTLSALPSPVVTSGGNVTLQCVSQVEFDGFILCKEGEDEHPQCLNHARGSSRAIFSVGPVSPSRRWSYRCYAYDSSSPYVWSSPSDLLELLVLGVSKKPSLSVQPGPVVAPGEKLTLQCGSDAGYDRFVLYKDGERDFLQLAGAQPQAGLSQANFTLGPVRPSHGGQYRCYGAHNLSSEWSAPSDPLDILITGQIPDRPSLSVQPGPTVASGENVTLLCQSWQQFHTFLLTKAGAADAPLHLRSTQKSPQYQAEFPMSPVTSAHAGTYRCYGSLNSDPYLLTHPSEPLELVVSGPSGGPSSPTTGPTSTSAGPEDQPHTPTGSDPQSAPGLGSGAGTRAAGLGRHLGVVIGILVAVVLLLLLLLLLFLVLRHRRQGKRWTSTQRKADFQHPAGAVGPEPTDRGLQRRSSPAADAQEENLYAAVKDTQPEDGVKLDTRESPHDEDPQAVTYAKVKHSRPRREMASPPSPLSEEFLDTKDRQAEEDRQMDTEPAASEAPQDVTYAQLNSLTLRWEAIEPPPSQEGPSPAVPSIYATLAIH
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MSGRGYGGLGGDPYMNGNSTGYANGNGNGYGNGRNANANGFPGQITEDGDYDPYNTGTDRYATPSPRQEGFRTPSPSMPRSPLSLGFPRMREPTAKPKLEETNAEKQIGEVLEHIKKEWPALCESGCVPVQLALQLLDTSSVGKAHEYAQFEQSMQYLQDSLKNIVHEHHQGFNSSIELKKLGAASTIYDELLHTLSEVEELRLVPDQLEARISEKRFLTAVDVLQDALRRIRSPELDDIGALSELRTYLANQETALTDILIEELHDHLYLKSPYCQERWQMLAKTQGGAAKEKFENPNGREGMRNSTVLLGGFRELWNLYQNEIRSLLHNYVTTDADVYQFDSPRPGASKSSKLEKLFKFSDADAKSVHMTTEYDELENIIRAAVPGLMSSSRKSGADSKKAKSFLESSAGRNGAKRLTGTAFDAKTGGMGTHKSLVEPSVFNMSLLLPPTLSFLQRLKAIVPPGSDLVTSTLTSFLDNFLVNVFLPQLDETLGKLSDSVFEETDAFQQDAQWARVSRRPVFKGTAAFFNLITAFCRMLDTIPHDQALSQLIITQMMRYYDRCYDWFKSLVSRVSDSEGSTLKLSALLASEPGDVHDTMQKIWTSEAVDRQLLDKETHLLILQTNENPLQVDDIISDRETISSLCVLYTSMKWLAIKIGQLRHITRNDADSSRTQSMQKPPHRRWTLLNDPRGQDEQNMVYLPMTQETVVAFDSIVSSYQELAATVLLTLHMETRIQILHSLTRVLSTSSGSNPYPYILSQPVSEPDPTILSLNADLVAYDETIVKFLRDKEINFVRNGLGLLIDTFMVDNASKIQRINKEGGKRMRLNVLVLQQNLKGVEDGVGLVRSSRYWGLFEEGPEGIVAWAKEKGGSNGGSSGAGGGDGNGNEVAAPAEDEVKFNYDELKALVELFFSEPLGSNERGITTVAKRGMGECMLQLSEYMWQS
The following text describes a protein:
Function:
Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3'-5' exonuclease activity. The delta subunit is the wrench that will open the beta subunit dimer. The DNA clamp loading complex (tau(3),delta,delta') is thought to load beta dimers onto DNA by binding ATP which alters the complex's conformation so it can bind beta sliding clamp dimers and open them at one interface. Primed DNA is recognized, ATP is hydrolyzed releasing the clamp loading complex and closing the beta sliding clamp ring around the primed DNA.
Sequence:
MTIIYGQDIGLIHQKLSQIKSNSPYKTIWFKDLKQLYDLFSQPLFGSNNEKFIVNNCSFLEKTSLTRQENLCLEKLKTTDVVLTVYTDNPFSGIKTIKSITTVFCDKLDWKSMHKAIGEVCRELNLKLDLEIIDWLANALPLNMGVIYQEINKLSLLGKNEIKDNKLVETVICDYQPVQIYKLTKALTNSQIVKAFKYIDELASTKPNFATQFLEFFSGELLLALMVKSCNPKQLTNINLNVNQFRLIAIQSQYHNFTSKVLVNIINAIQKLDIKLKHNDGFAIPLLKNFALSFFTN
The following text describes a protein:
Function:
Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MKIAIALLACLGLAAAASFHQTHEVKIADKAFLMKQKFLFEIVYRVEDPLMFEDHIKQGEKFYFEESYYTHYDMYMKKFFEAYKAHALLPKGEFFGALVMSHAKQARGLFNFFYYAKDWETFAANVAWARMHVNEGMFVYALTMAVIHRNDFHGLMLPSIYEIFPQFFFNSKFVFEAEKFDYEMWMKMTMYEKEYMDVYYKTNGYDYSTMYRSSDYTYMKDFKTWQWWKLMGLGEHWYTEDKFILRENIYEFNQETKWLSMMKDVKKFYMPVDYTRDLNLYNKESKLSYFTEDLGWNAYWYYLNMDYSFFLDGNTFDLKNDRRGEWWLYNVHQLLSRYYMERLSHGFGEIPEFSWYQQIEMGYDPQLIYYNGIGYSFRKNYYEMETYANYDMLDKITGFLKRIHNIVEMGYYKTADGHTIDLRKPEAIEFIGNMLQGNVDAMDKMFYQFWYMLAHMYFADADYYQMDVYPNVMLNFETMMRDPMYYMFYKSIAQVYFQFMHYLPKYTKEQLLMPGVTMKNVEVSDLTTYFDLVDFDVTNMLNDKMIFQDGKFVWDMSLFARQMRLNHKPFTYTYTIESEKVEKVVIRAFLGPKFDEFGKVISLAENRMNFMEIDEFYYELKAGTNKITRKSSEFYWTVKDRTTYTELYYYTMMAFDGKYDFPLDISEPHCGFPDRLVLPMGWQKGMPMQMFFMVVPYVAPAHEQFSTFDYTYSCGIGSGARYVDSLPFGYPFDRAIDEYEFFVPNMYFKDVSIYHADTMEPYYKYKSYSNYGHFDYTFFNDYYTKYFKF
The following text describes a protein:
Function:
Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEARRQQDPSPGSNLGGGDDLKLR
The following text describes a protein:
Function:
Involved in resistance to methylmercury. Overexpression suppresses a PAM1-SLV3 double null mutation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSTFNSYSQPKESNDNSHNNVNKSKSLLDIIFGTNVSEWAFSENALMKAMDLKIEQEKTKQQYYKLENLNRSIELFKLASSSGLPINQIHKLFNTDHGVPASSPMKAGGNQPHNNTEGTQSSENLPRLNGSMKSLKPLNMNTVSPTPMSRQPSPYKFPASSSTGGISHSTVTNVQRRANSPARIGASAVAALNDNISIKEEDVARRIPSGTKSQESPLNKKPTSLHSRNLSLPIGKFTNPNIPSTMTSILSFNRDQQQPLSQPLPPPPQQQQDLHTHNLHTIPRKPGMVQKKHRRARSTSSFGVIDLSIIDEAKEKQVQRSPSPIHSNVSVALTSHDKPIESNMKEQPNMLQSVREGRQVHDDLDDRTCSESSSRNESPVRTITKDNSVGKILNST
The following text describes a protein:
Function:
Thioesterase; part of the pkg gene cluster that mediates the biosynthesis of dihydrocitreoisocoumarin and 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin. The non-reducing polyketide synthase pkgA performs the condensation of one acetyl-CoA starter unit with 6 and 5 malonyl-CoA units, respectively. As pkgA lacks a releasing domain, the thioesterase pkgB is necessary to break the thioester bond and release dihydrocitreoisocoumarin and 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin from pkgA.
Sequence:
MSGGFYSSPFWAGYLETQRSRLPVLPEIDDGLSHCVVRFLGYNPGSMQLQGTNTYLVGTGSTRILIDTGEGAPQWAVSVTRYLEDHDISISHVLLTHWHKDHTGGVADLLAHDPSIIVYKHAPDPGQQAIANGQTFKTQGATLRAVLTPGHAVDHMCFLLEEENALFTGDNVLGHGYSVAEDLETYTASLRLMAGLKCSVGYPGHGDAILNLPQTIARYISQRVAREKKIYAILALHACSCSSRNGGSTSSIGSVSESGDSDEEDNNMKTSRPAMQGLSTAEIGGLVYGESVKNSPTFDSAVGPLLNQVLYMLLEQGKCCDHVSILVIFQKPGFFSIPVI
The following text describes a protein:
Function:
Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSTTTMNIASAPIEVKRIYWPKSTISYTDSGYLVGWKYSTNDLIVVTTITSYQSFANFLVDYCKNQDQSVDIKSLCILGTFNCSADILPGDKYEIDCWIKVQQSTELSHPRVFDSASTPLKINLHIIYYHPPQPRKMQFLSLEPLSLLLLKDSFINKSNPEYESMQHQQILLKKLKLHFPRRKENSWKRSLRSGLIELLNQSFEVRMLTHENNNKKNSYVFRLFDRVSSSTFYFFNSLFAYFIILLRIINEVILLAINYRPIPLSYNMMDIFVSARQVDLRLQQACFWPVQYMKLWVFRKSKRVAIEDYKEYIRFYNNLWLVANDMIFGITMSSFILENLHLVVKLIENITFEYAIKNVRSMVIWLVDTPAGLKLNNDICKFIMKLSVWVIDVWSNFLLHCLPWTPFLVQVVAISGFGGASLMIALISDFLSVMTIHIHLLYLASSRLYNWQLRVIYSLLQLFRGKKRNVLRNRIDSYEYDLDQLLLGTILFTVLIFFLPTIYVFYAAFALTRVSVMTCLAICETMLAFLNHFPLFVTMLRIKDPYRIPSGLNFEIVSFEPLKQDGFATLYLNCNSKPMSLGSMFEHYRKLARRLISHYLSKTTLISLLVGCPVPAIPAEQLYNIQYAMLPTKRISIRKLRDLLFHQKKFPYD
The following text describes a protein:
Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells. Via its association with the PRC1-like complex, promotes epigenetic repressive marks H3K27me3 and H2AK119ub marks in nonrod genes, silencing their transcription. Represses Crx-controlled photoreceptor-specific gene expression.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Co-localizes with PHC2 and RNF2 in nuclear polycomb bodies.
Domain:
The SAM domain mediates its oligomerization and localization to nuclear polycomb bodies.
Sequence:
MAVNPLLTPTGQQTIPLIPSPFGPPTVDRDVLPSTVAPTDPRQFCVPSQFGSSVLPNTNMANVLSSRIYPGWGILPPESIKAVARRNEMIQRHHTARTEMEMYAIYQQRRMEKINPKGLAGLGIPFLYGSSVPAAPAAYHGRSMLPAGDLHFHRSTLRNLQGNPMLAATAPHFEESWGQRCRRLRKNTGNQKALDSDAESSKSQAEEKILGQTHAVPYEEDHYAKDPDIEAPSNQKSSETNEKPTTALANTCGELEPTHRKPWGSHTTTLKAKAWDDGKEEASEQIFATCDEKNGVCPPVPRPSLPGTHALVTIGGNLSLDEDIQKWTVDDVHSFIRSLPGCSDYAQVFKDHAIDGETLPLLTEEHLRGTMGLKLGPALKIQSQVSQHVGSMFYKKTLSFPIRQAFDQPADTSPLLDPNSWSDTMNIFCPQDTIIPKGIERGSMRN
The following text describes a protein:
Function:
Myosins are actin-based motor molecules with ATPase activity. Involved in phagocytosis and motility, and in the maintenance and dynamics of cell cortex.
Subcellular Localization:
Cytoplasm. Note=Enriched in actin cortex regions.
Domain:
The head domain possess two actin-binding sites, a classic ATP-dependent one and a secondary salt-dependent one (located inside the GPR domain).
Sequence:
MFRLFSSGVDDLVLVSNPSNGEVTSQIGARFDRELIYTNIGEVLIAVNPYKALPITGPEFIKLYQNASGSDASPHIYALAERAYRRMVDENESQCVIISGESGAGKTVSAKLILQYVTSVSPNNSSGGGIGGSGGGNGGIPQYDGGSDDRPSPPMGRGMGMPGMVGRGGLPTRGGGPPSRGGGPPPTRGRGGPPPPIPQNRGAPPPVSNGGAPPPVARGPVAPPPTRGAPPTRGGGPANRGGRGGGPPPVSTSRGGGGYGGSSKTVDVEHIKKVILDSNPLMEAIGNAKTVRNDNSSRFGKYLEIQFDDNNAPVGGLISTFLLEKTRVTFQQKNERNFHIFYQMLGGLDQTTKSEWGLTQATDFYYLAQSKCTTVEDVDDGKDFHEVKAAMETVGISRDEQTEIFRILAAILHVGNIRFQGEAPASVIDETPLQWAASLLGCDPTFLCQSLNHRQIQSGSARHTQYQVPQNPDQSAGLRDALAKTLYERIFDFIVARVNKAMSFSGNCKVIGVLDIYGFEVFERNSFEQFCINYVNERLQQIFIDLTVRGEQREYHEEGMKWKDISFFDNKIVVDLIDGNKPPGIMRVLDDVCKTVHAVDSAAADIKFMEKLIHSIQSHPHLVISNTGSSADEFTIKHYAGEVSYSIEEFCFKNNDNLYASIVGCLQNSTYQFIVSLFPENIQDNKQAPTTSSFKIRQSSSYLVTRLSACTPHYIRCIKPNDKKQPMNFVSSRVEHQVKYLGILENIKVKRSGYAYRQLKDIFLNRFGKIMDVQPRNVQEFVEYITRTHKDINADEFEEGKTKIFVKNPETIFVMEDLLMQKIDPIGYKNRVQAYKENEKLAQMKQGKHSMKQKCLIQ
The following text describes a protein:
Function:
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
Sequence:
MSIITVQIGQCGNQLGFEFFNVLSQDIRRAESAECYNGYSQKYCQLSNERFFTSDSKDGLVASAVLIDTEKKVVGKALVDACRSNQWHYAKDSCYTHQQGAGNNWASGYIEHAERGLDSIMELIRRRVERCDWLDGFLPLMSLGGGTGSGLGTRVTEALSQDYPNTPLVNIVVRPFSSGEVAVQAYNAVLSLSHLQDSSDALVVLNNDGLHHVASKRWAVKNASLSHLNVVAAQQLACLLQPSKTAEGLPTRIGSPCAGDVPVELGCHSQLRLVTLLQVPQEPPHVAPFSCATWPGLVRSLHKMRLCRSSTDEGLPLVHTLAVSTSPPHIPAMGAEGRPLRSVAALSVARGDGLSSSGAPVPGETLFGTPSPASWTCPRRFLGRGRTLLLADNHQGCLSFLEPLLSRAWGRFTEGAFLHHYTRHGLQVEDLADAFVRLEQTLEAYRQLSGS
The following text describes a protein:
Function:
Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MATKRVLTPNILENDNTDVTSSNPQKKFKEQLDFSSDEVENIDWGDNDDFDLALIAAMDSISNHRLELTKWQRCEVVRLEQLPNRKGLKVHVKRISGGDPETADCQLLPPWNCMPMQVGDTVSLLGKWDPSAGCYVVDKEQGYCVSHPDFLISGTTVTGSLFCKRKSVLQERFRGLDSGNSVMVIGTLVHELLQKVLRQKLFDKKHIQSALQEMLASSSLAHLLYASNLIQVEMEDHLMKFIDPIVSFVAQYVKGEPPSVLLPEVYRGQIHEICDIEENLWVPQLGLKGKVDVSVKVKNQRQREEIIPLELKTGRASFSMEHKGQLLLYQLMHSAQGRDTQSGLLLYLKEGLLREVASGRNEQRDLLMLRNDLAYWLTREVAIPASKEDPLEQLPLPEPVYHHSACGNCAYNTICSSFAQKDSSLQLSDSHPLKKLMPQLLEHLSEADHAYVQHWCGLLALEEQHNRQSSHVRSFWTKDPAEREKEGIAIRHLKLVKGQEVILEEGRYRQTLELGEEADPSRDLSLSGFDLGEYVVISSTSRLAVAAGFIVSIEARRLDLRLERDLSQRYSEETFIIDKHDSQSFATFNFTNLGMLLSEGERFQELRDIIVAKKPPEQHKVLPKIILTKGAPILLNLNKVQQNAALRALTTSSHLLIKGLPGTGKTQTLVALVRLLHLLGKSVLITAQTHSAVDNLIMRLLPFGLPMMRLGSGSRIHKQLEEISEERLTKDCKTVEELEKALGQPSIVGVTCLGCGHPLFQRRQFDYCIVDEATQVLQPTVLRPLIHCSKFVLVGDPEQLPPIVRSKEARQRGADETLFQRLDSEKATAVLSLQYRMNKTITRLANELTYGGDLKCASDEVSGARFEVELLNEAPRWVQRALTTHLEQAVTLINTGDCLERCQEFVYASQRLVDTCSSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLLKSGYEASRIGVIAPYRAQVELFKKLASKLDTDLECNTVDQFQGRDKNLIIYSCSKTGGDFSDMERSREAEILEDQRRLTVAITRAKNKLILLGDIKCLEQYGPFRQLFKHIPDRCRLKLEEGRMEFGWQRIQEDLVGLMDT
The following text describes a protein:
Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MVLSEHLLVLLGAVLCAPALSDVLFRCPPCSPERLAACPGNSPRSPCAELVRAPGCGCCPVCARLEGESCGVYTARCAGGLRCYPHPGSELPLQALVLGLGTCGKRRDAEYGSSQERGTELPEDQSDNMLVDNNLVAGPAVPGDFMPRKSSKAHAVNRERANEQHRSKTNKSEDKKRPARSLCQLQLDQVLERISGMHLPDDRGPLEHLYALPIPNCDKNGFFNLKQCKMSVNGQRGECWCVNPITGKVLPGSPTVRGDPECHLFYTNPEEERRAHTQRAP
The following text describes a protein:
Function:
Functions as a meiosis-specific transcription factor. Binds to the 5'-GTAAAYA-3' consensus sequence of the promoter of the spo6 gene.
Subcellular Localization:
Nucleus.
Sequence:
MVENQGNVEAHGKPKKVILSLSLKESSKINDSQNVSNVSSKEKCETEALLREENKENLSSDSIRQMIFGDEMAGFVDTGEKPPCSYATLIGLAILQSHNKQLTLSGIYTWIRNTFRYYLNHDGGWQNSIRHNLSLNKAFIKVEKPKGKTLKGHYWTIDPDHMQNFVSVRLHRSHSTDSNSKKRPSSKCHEIKPLTTREIPLARKRSRLNSFNSSTSTSGSSSNVAAEVSNDASQPSNQDSSLNSNIVKPPLPPSNVQSNSSSSENVPKPNAETQEDLPTIDAHESSLYENVNDSRLYEVPACRNMALNTGYSDADPGYLRTSFRSNSHNSLPYSANEEEDVLQADFLVSQQSSMVSSYVSSRDPHSMPYYRREPIPLRPSSRFYEYTRPTYGRTDTSCSAPGAFCSTQINSPSSYINYSKCAPSSPTLSLQKHREHVKSLLYVPDLTPSFDGSDPWNPSSQLLSEPLFDQHSFQSSLDDLMSVTCFRDSPELNHESSGYSSAPLMPSNRAFINDFSL
The following text describes a protein:
Function:
Probable chloride channel.
Subcellular Localization:
Cytoplasm. Membrane. Lysosome membrane. Golgi apparatus membrane. Note=Can be translocated to membranes, possibly as integral membrane proteins, with chloride channel activity (By similarity). Localizes to lysosomal membranes in the intestine, and to Golgi apparatus in neurons and muscle. It also localizes to dense bodies, a transmembrane structure which links the muscle cytoskeleton to the neighboring hypodermis.
Domain:
Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as a chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).
Sequence:
MPTFSLWLPAGSNNVHPCGDPYAHHLFMRCLYHAKHDPTMKFDVKTTNVNKTSQEFKNTGLRRMPGISAEESGETQTFETEDDILDFLEYLKPERGDDEEAENATCDLFRQFARFVKDVEHRDTAFNTELLRLDKYLSEQETKFLISDDVTHIDCLVLTRLHSIRVAAKMLKNYEIPADLSHVLDYLKAGYATEMFRVSCPSDQEIVLHWTELKDTPRLSAKDRAKLVREEPVFSFSV
The following text describes a protein:
Function:
Involved in maintenance of ploidy through proteasome dependent degradation of CDK inhibitor rum1 and S-phase initiator cdc18. Functions as a recognition factor for rum1 and cdc18, which are subsequently ubiquitinated and targeted to the 26S proteasome for degradation. Together with pop1, required for cig2 instability during G2 and M phase and cig2 degradation in exponentially growing cells.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSLSRCPTDNSSSRINSSVPLINSSSPATPPESFDPQVFPSSLIHGDNLLPQDDQIASDPRSESNSCNGNTSSSLPCTDSYQYPLKHSCTPSFLRKFNESIENVSYKCLDHSPPDSVPGDFSISLVPQRNFLYSHSSLPPKIISIDRNNRIKLDNSISSNSDNFPPSPKVDTSNTVSPGSKPISEDLEDLNLQSIVQTFEDLPEGIQSYAFFQLLRSCNRQSMRLLLNECEPLLKKDILSNLPFSIVQSILLNLDIHSFLSCRLVSPTWNRILDVHTSYWKHMFSLFGFQINENDWKYANPNLNRPPFLHNDQISDDYFPEIFKRHFLNRKRWLFPSIPPSHLSFPIHVPNFMITSLLLHKDRIITTSGSGTIQIHNAITGVLEARLEGHKEGVWAVKIHENTLVSGSIDKTVRVWNIEKAKCTHIFRGHISIIRCLEILVPSRLIRHGVEIVEPDQPYIVSGSRDHTLRVWKLPKNTDPPYLPDNTNSIDRWEKNPYFVHTLIGHTDSVRTISGYGDILVSGSYDSSIRIWRVSTGECLYHLRGHSLRIYSVLYEPERNICISGSMDKSIRVWDLSTGTCKYVLEGHDAFVTLLNVFQNRLISGSADSTIRIWDLNTGKPLMVLPSNSGYISSFVSDEHKIISGNDGSVKLWDVRTGKLLRFLLTDLTKIWHVDFDAMRCVAAVQRDDQAYLEVINFSGSRP
The following text describes a protein:
Function:
May couple lipid signals to the activation-loop phosphorylation of several protein kinases of the so-called AGC kinase family. Interacts via its pleckstrin homology domain with phosphatidic acid, PtdIns3P and PtdIns(3,4)P2 and to a lesser extent with PtdIns(4,5)P2 and PtdIns4P. May play a general role in signaling processes controlling the pathogen/stress response, polar auxin transport and development. Transphosphorylates the AGC protein kinases OXI1/AGC2-1, PK1/S6K1, PK19/S6K2 and PID resulting in their activation.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation.
Domain:
The PH domain is responsible for the interaction with the 3-phosphoinositides. The activation loop within the kinase domain is the target of phosphorylation. The PIF-binding region in the kinase domain of PDK1 acts as a docking site, enabling it to interact with and enhance the phosphorylation of substrates containing the PIF motif; The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.
Sequence:
MLAMEKEFDSKLVLQGNSSNGANVSRSKSFSFKAPQENFTSHDFEFGKIYGVGSYSKVVRAKKKETGTVYALKIMDKKFITKENKTAYVKLERIVLDQLEHPGIIKLYFTFQDTSSLYMALESCEGGELFDQITRKGRLSEDEARFYTAEVVDALEYIHSMGLIHRDIKPENLLLTSDGHIKIADFGSVKPMQDSQITVLPNAASDDKACTFVGTAAYVPPEVLNSSPATFGNDLWALGCTLYQMLSGTSPFKDASEWLIFQRIIARDIKFPNHFSEAARDLIDRLLDTEPSRRPGAGSEGYVALKRHPFFNGVDWKNLRSQTPPKLAPDPASQTASPERDDTHGSPWNLTHIGDSLATQNEGHSAPPTSSESSGSITRLASIDSFDSRWQQFLEPGESVLMISAVKKLQKITSKKVQLILTNKPKLIYVDPSKLVVKGNIIWSDNSNDLNVVVTSPSHFKICTPKKVLSFEDAKQRASVWKKAIETLQNR
The following text describes a protein:
Function:
Involved in the oxidative degradation of abscisic acid.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MAFFLLLLCILISAAIVSYAHHVIRRQRQGCAHGRHEQAALKLPLGSMGLPYIGETLQLYSQDPSVFLSSKQKRYGEIFKTHLLGCPCVMLASPEAARFVLVSRANLFKPTYPRSKERLIGPSALFFHQGDYHLRLRRLVQGPLGPEALRKLVPDIEAAVRATLAAWADGDVASTFHAMKRLSFDVGIVTIFGGRLDERRKEELRRNYAVVEKGYNSFPNSFPGTLYYKAIQARRRLNGVLSDILHERRERGEPGDDLLGCLMRSRAGGDDGDEGALLTDEQVADNVIGVLFAAQDTTASVLTWIVKYLHDRPKLLEAVRAEHAAIHEANDGGRRPLTWAQTRSMTLTHRVILESLRMASIISFTFREAVADVEYKGFLIPKGWKVMPLFRNIHHSPDYFQDPQKFDPSRFKVAPRPSTFTPFGSGVHACPGNELAKLEMLVLIHHLVTGYRWEVVGSSDDVEYSPFPVPQNGLLARLRRDDSVCVGRKGCATDDNYDDEDEVIV