lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MAARAPVATGRLMLGFRKWYYNLCGFNKLGLMRDDTIIEDADVKEALRRLPERVYNDRMFRIKRALDLSMKQQILPKEQWTKYEEDFYLTPYLEEVIRERNEKEEWMKK
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MQLPDWIETECQPNSNHPYHDLSRHIQPFGSRTMASSIFKQALPSAVREIRLHFSPTQANPVKSFIQSNYSSIKSSNPDLPFLFRESSIGTPARAIVRFEYGIEKQVSLEQAKSSTEIESLLSNLIQSKN
The following text describes a protein:
Function:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Sequence:
MADVATKIPDANWVRLEIEPVQVSHDQDATLNFATVQSVVPGAHGLYYRDDGERKALLFDNNTGKVYPPPNGWDSVPIFIHLAHGSRHGTHFADYSKANDAFEKNISAVQKLFAAAGLGGRSQKVYAAGKTRARSTSKKNQPRSQFDAQPENVNISEESEGRDSEKEKNDRQLEKLRNRNDELKIRVKEYKSDLSAAQLKVKNLEKKLESAQSADSEEKFVRIDSEIDEKRSQDHDEEINNLHNVIEELRNKLATVESKNKDLETKFSENQDYLKNAKDKVTFLENQLNSDAHEEVKSTAVRALEVKLGLANNSIRQAEAEKQQLQEANWYANERVGKLEQENGYLKGITEQLKARADTSHAEKMLKDSEKRVWEINEEKSKLEWRLGELSQWWNDAKWKVGELESSVALQRNLLDTANSKIQSLNDQLIQEVRSHSSTMTIPTDGFTISQSNQGTWNLANGSNQPCFTGAIPSIPLVSALPFAGANPFIFGGANEGRNVTLTISNTEQEVYLTGSFINWKCTLKCEKLVSGKKGVTVNLTRGRHEFRFMINGEWATSSDYQQVPNGLGGQNNIIFVE
The following text describes a protein:
Function:
E3 ubiquitin ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their ubiquitination. Plays a role in the regulation of antiviral responses by promoting the degradation of TRAF3, TLR4 and TLR9. In turn, down-regulates NF-kappa-B and IRF3 activation as well as beta interferon production. Also participates in the regulation of autophagy by ubiquitinating BECN1 leading to its degradation and autophagy inhibition. Plays a role in ARC-dependent synaptic plasticity by mediating ARC ubiquitination resulting in its rapid proteasomal degradation (By similarity). Plays aso an essential role in spermatogenesis and male fertility. Mechanistically, regulates meiosis by promoting the degradation of PRKACB through the ubiquitin-mediated lysosome pathway. Modulates the gonadotropin-releasing hormone signal pathway by affecting the stability of STAU2 that is required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle.
Domain:
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Sequence:
MAEGNNKEEVIHLNNFPCHRGKEWMAVREGPITISDSSDEEGIPMLVTPATEQQEDDLDDDVILTEDDSEDEYGGFLDLESGKKEGEAKPGPSSKQTADDIVNPRLEQKVIILGENGLLFPESEPLEVQNQSSEDSETELLSNPGEPAASVDDQLIGEEYWLDHPYFQAPNPQPQERTNQVVPQERHSESEMGPMFFRHDFPEPAFPRPEPQQEGIPGPASPQPAHPLGELEDQQLAIDEDPGPAFPLSGPQEANLANMWEQEAAEVDQDLIPLLVKETEARFPDVASGYVEEIIHLKNYYDLNVLCNFLLENPDYPKREDRLIIHPSSSLLASQDDAKLPKIDFFDYSKLTPLDQRCFIQAADLLMADFKMLSSQDIKWALHELKGHYAITRKAFSDAIKKWQELSPETSGKRKKRKEMNQYSFIDFKFEQGNIKIEKRMFFLENKRRHCRYYDHQALLPAVKQEQEFYEQKIKEMAEHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEELTQCADAHLFCKECLIRYAQEAVFGSGKSELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPNPRCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSINGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEEEQKRKNGENTFKRIGPPLEKPAEKVQRVEALPRPVPQNLHPQMPPYAFVHPPFPLPPVRPVFNNFPINMGPVPAPYVPPLPNVRVNYDFGHMHVPLEHNLPMHFGPQPRHRF
The following text describes a protein:
Function:
Involved in the synthesis of catecholamines, such as dopamine. Has a role in serotonin signaling. Required for normal explorative and foraging behavior (By similarity).
Subcellular Localization:
Cytoplasm, perinuclear region. Cell projection, axon. Note=Expressed in dopaminergic axons and axon terminals.
Sequence:
MSSLTNPTTVMEEEEVPVAAPIRRGNKNPRRYSLVHQASCETQHHIGIRRQNTIQHRKQLTDQMREQKILQQLNDEGVEVIFAANDVSSIDFSVIVTSTDYISTFVSDILYNMKSAGVQICHVETRESKAVSGHDVLLDCRATKNQLIKAAELLTQNHVALTHFSIFSKKSVEKSQSMIWFPRHISELDQCSKCITKYEPTTDPRHPGHGDDEYIARRKFLNDQALEFKFGDEIGYVEYTEDEHATWKAVYEKLGGLHESHTCSVYRQNLKILQKEKVLTADRIPQIRDVNKFLQKKTGFELRPCSGLLSARDFLASLAFRVFQTTTYLRHHKSPHHSPEPDLIHELLGHVPMFSDPLLAQMSQDIGLMSLGASDEHIEKLATVYWFIVEFGLCKEDGKLKAIGAGLLSAYGELIHACSDAPEHKDFDPAVTAIQKYEDDDYQPLYFVADSIHDALAKLRKYASSMDRPFSVVYDPFTKSIETIQSSADLEKAFSRLSNDLSAITHAADRMKISITA
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Sequence:
MAEGRESAEEGGEVRSEQKKRIWGMHGERDGESSVSPATAGRWDCGSGGAARPWERREPSGVAGAAKRRELGGVAGWREQRERERAEVRKPRRLLSSLPVAASPPTPLLRRLIPNQLLSFAASSISCPIEGQVGTISSRAVRRCTSQWREITVAFASINHKLAERGDGDEEGSHGGAVWLVNGVLLHAALVADAQTLVYKYYAQKCPAAESIVFDEVQKAWNAHRSMPASLLRLHFFHDCFVNGGTAG
The following text describes a protein:
Function:
Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVSTTLATITIMSTLVGYTTGPLTDYMWLLIVGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETLGSVLLGAKVSETIRKGIIDVTMYKDIEHVLMAGSVSAMFGSAVWQLAASFLKLPISGTHCIVGATIGFSLVAKGQQGVKWLELLRIVASWFLSPLLSGVMSAVLFYFVRMFILQKKDPVPNGLRALPFFYAVTMGINLFSIMFTGAPMLGFDKLPWWGVLLISIGFGIITALIVWFAVCPRLKKKIECEVKSSSPSESPLMEKRELHEAHSPILKPVPEESSVLSSSTPTTPPLPPPEERRVTFDIGDSDDADQKDCKESDLGGAPKTAHVHFTNGPAHIPSNGYSQYHTVHKDSGLYKDLLHKLHLAKVGDCMGEGGDRPIRRNNSYTSYTMAIIGMHGDFKPKESEFRASEDGDKEKAGAQERKRIRMDSYTSYCNAVAENGTPEDLGEGEVTLEMVDEDAGSSRSSLEEDRTDADKPEVSMLFQFLQILTACFGSFAHGGNDVSNAIGPLVALWLVYESGSVISSAPTPIWLLLYGGVGICVGLWVWGRRVIQTMGRDLTPITPSSGFSIELASAVTVVVASNIGLPVSTTHCKVGSVVAVGWLRSRKAVDWRLFRNIFMAWFVTVPISGLISAAIMALFNYVIL
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MPEVKDLSEALPELPLDPITGVGVLASRNRAPTGYDVVAQTADGVDADLWKDGLFKSKVTRYLCFTRSFSKENSHLGNVLVDMKLIDIKDTLPVGFIPIQETVDTQEVAFRKKRLCIKFIPRDSTEAAICDVRILGRTKQAPPQYTFIGELNSMGIWYRMGRVPRNHESSQSTTPSSQSSASTPAPNLPRHISLTLPATFRGRNSTRTDHEYQHSNLYAISAMDGVPFMISEKFAGVPGSMQQVDLLGITIKSLAEIEKEYDYSFRTEQSAAARLPPSPTRCQQIPQS
The following text describes a protein:
Function:
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
Subcellular Localization:
Mitochondrion.
Sequence:
MDILLNKPITIVGGGLAGSALALLLGQKGFPIQVIEKRPKQSENIRARSINLALSDRGVKTLTKTGYVDDILKIAIPMKGRMIHSLDSVQTFQAYSSDSNKHLYSVSRQLLNDRLREHTEKLENVKFIFSDACKSIDLKQCTIQTQDSNQTIEASTIIGCDGAFSAVRGSMVKLDRQDYSQSYLKHGYKELCIPSGPNQTFQIDKNSLHIWPRGSFMMIALPNIDGSFTCTLFFPFDGPLSFSSLDTREKVDQFFKDYFPDAYKLMPDLLDDYFENPTSSLVTVKTEPYHYQGKVVLVGDAAHAIVPFYGQGMNAAFEDVLELFNCFEDKSLYPSSTDKPFDNDHFNNIYKKYQENRKANSDAIAEMAVENFFEMRDHVGDALFLFKKKVEHLLEVKFPSRYISRYELISFSTQPYAYAQKIGLANQQILNELVKGNDDYNIEKIDLVLADQLIKKYLNK
The following text describes a protein:
Function:
Ubiquitin thioesterase that acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole. Also removes ubiquitin from soluble proteins targeted to proteasomes. Is essential to maintain a normal level of free ubiquitin. Involved in the ammonium-induced down-regulation of the GAP1 permease and the UME3 destruction in response to oxidative stress. Has a role in the RAD9 checkpoint response to TOP1 poisons. Required for promoting coordination of DNA replication and avoids DNA overreplication.
Miscellaneous:
MISCELLANEOUS: Present with 428 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Late endosome membrane; Peripheral membrane protein. Note=Recruited to the late endosome by BRO1.
Domain:
Residues 1-208 are essential for the localization to the late endosome and constitute a late endosome localization (LEL) domain.
Sequence:
MEQNIISTIRDECIRHRSKYLTIAQLTAIAEAKINEFIITGKAKDQDLSSLLDKCIDILSIYKKNSKDIKNIISCKNKGAMISSNSVMIIQLNYVYYKVIHIIVTTNIPHLSEFAKIKLHKSTSDEGNGNNNNNEFQLMNIYNTLLETLLKDENIAKIKSFIKSSIKQTKLNHEQEECNLMRTGSYITSNQLNSLISSSANSASSQMEILLIDIRSRLEFNKSHIDTKNIICLEPISFKMSYSDHDLEKKSLITSPNSEIKMFQSRNLFKFIILYTDANEYNVKQQSVLLDILVNHSFEKPISDDFTKIFILESGFPGWLKSNYGRQVSSSFPSNNNIKDDSVYINGNTSGLSLQHLPKMSPSIRHSMDDSMKEMLVAPTPLNHLQQQQQQQSDNDHVLKRSSSFKKLFSNYTSPNPKNSNSNLYSISSLSISSSPSPLPLHSPDPVKGNSLPINYPETPHLWKNSETDFMTNQREQLNHNSFAHIAPINTKAITSPSRTATPKLQRFPQTISMNLNMNSNGHSSATSTIQPSCLSLSNNDSLDHTDVTPTSSHNYDLDFAVGLENLGNSCYMNCIIQCILGTHELTQIFLDDSYAKHININSKLGSKGILAKYFARLVHMMYKEQVDGSKKISISPIKFKLACGSVNSLFKTASQQDCQEFCQFLLDGLHEDLNQCGSNPPLKELSQEAEARREKLSLRIASSIEWERFLTTDFSVIVDLFQGQYASRLKCKVCSHTSTTYQPFTVLSIPIPKKNSRNNITIEDCFREFTKCENLEVDEQWLCPHCEKRQPSTKQLTITRLPRNLIVHLKRFDNLLNKNNDFVIYPFLLDLTPFWANDFDGVFPPGVNDDELPIRGQIPPFKYELYGVACHFGTLYGGHYTAYVKKGLKKGWLYFDDTKYKPVKNKADAINSNAYVLFYHRVYGV
The following text describes a protein:
Function:
Plays an important role in the elongation step of protein synthesis.
Sequence:
MAVSQLTCIYSYLILHNDEVMVTQDKINALIKVAGVNVEPFWPGLFVKGPNDVNIGSLICNIVVGAAPEFSLAVLHPWNVLLPHFCLLPLLASFKSQLKSYFLQQAFSSPS
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MTNWKLEISYIGKDFYGFQKQPGKRTIQGELEKVLSFLFDEEIRVIGAGRTDTGVHALGQVVNFKSRGHKGFSCDKLHKVLNRLLPEDIKIKKVEIVDDSFHARYSAKRRWYIYVVYNNDERDLFLKDYSWWISREINRELLIFSANLFKGVHDFKNFCVTEDEDQTVIEVYESFWYFKKDLLIYFISAPFFLRKMVRFIVGSMVEIALGRKSLIELEDYLKEERKERFSVPAPPWGLYLFRVDY
The following text describes a protein:
Function:
Required for mitoribosome formation and stability, and mitochondrial translation.
Subcellular Localization:
Mitochondrion.
Sequence:
MRRVVAAAIRTERAFSTRFSASQQKPVASTSSSSSVPDRATLEKGTVQPTVLKPFVSASLQHEDLFNFEKMVHIDEMFKARLHYGHKVGTVNNNMKWALYGERLGVCLFDLDITKKYLVRALNFVAHVSLRGGMILFVTSNRDTMFDVEKAADEVGQYSHVRKWQSGTLTNTRQLLGASVRLPDAVCFLSTLTSLGENHPAIVEAAKMAIPTIGVVDSNSDPAYLTYLVPANDDTPQSTEYLLRMFKEAVRKGQEERKRQQQGK
The following text describes a protein:
Function:
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Subcellular Localization:
Cytoplasm.
Sequence:
MNLGIVGGGAMAEALIAGLIAGAVYAPSEIAVSDPVAERGEWLHRRYGVVAVTDNLVPAAAPTLLLAVKPQAFAVVSNQVAAHVRSELVVSILAGVPLARLQAAFTGRAVVRAMPNTPALVRSGITALSRSERVTPEQFAVARTLFACVGEVVEVPESAMDAVTGLSGSGPGYLALVVEALIDGGVAAGLPRATASQLVLATLRGSAELLIQEKLHPAVLKDRVTSPGGTTIAGIEQLEGRSVRGAFIEAVQAATRRARELSG
The following text describes a protein:
Function:
Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.
Sequence:
MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAQEETKTVLSDTEEIKPQTKKETYISCPLRGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLVPPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHLKVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENGYGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVLGFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQEKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLMCFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARVSAPHLEPYAKDVMTVAFLAILITAPNGALLMGILGPKMLTRHYDPSKIKLQLSTLEHH
The following text describes a protein:
Function:
Member of the two-component regulatory system DctS/DctR. Essential for expression of dctP.
Subcellular Localization:
Cytoplasm.
Sequence:
MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGMKLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGAVDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNHFTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRPVNRYVLKG
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MSIVVQDKEDQILTQLEHPQPDTKSPPKYIAYLAGVCSGINKNLVGHPFDTWKSRLQTAPKGRFKGPIDCAWQTLKYEGPFGFYKGFTPPLVGWVFMDSIMLGSLHTYRELVKDYIYPQEKKLPLVGHMIAGLGSGLTVSFVAAPIEQCKARLQVQYDKKSRTYSGPIDVAKKVYQAAGIRGIYSGLISTMIFRTNFIFWWGSYEIFTQYFEKNTKMSTPSINFWAGGLSATVFWIFAYPADVVKQNIMTDSPIQSEKKFPRWIDAVKYIYKEKGWRGFTKGFGPAILRSFPANAAALLAFEWVMRLSK
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MSSRGHNDGGPLAFIAILSIDEGEIKGIIAAVILDYLESELKVVFGCEDGGDDKIVRIANYFHTIAGTSIGGLITVMLTCPNEEGGPLFTAKEILDFYLEQSPKIFPQRRIFIIKLLTNLESFLQLIFPFNQHRAIRCLRSPKYDGKHLHNLMRKLLGKKRLHDTLTNIVIMTYDIKSSKGVTFSTRQDALLSDICISTSAAPIYLPSHDFQMAHISITKFNLVYGGVMTNNPGLVKWLYKKRDFPLLNILDEGNNTMMGKILPMHIKNLNAHRRYFRIQDDTLDGDKSSLDLATKKNLGIWWKLVKLCCEDKFL
The following text describes a protein:
Function:
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRCHLKKWVVVAAGLSILTSLYVYMQRAQSGNLKGSVIWTWDRESWMEGIKSHYLHFNISINVLGGVLQPSKKYLTVGLSSVRREKGFYLHDTLQSIFSESSEEELDQMVVVVLLADFDLPWIQQTADKISREFAVQLSKGRLLVIHANKEHYPPLTGLKRNFNDAPDRVSFRSKQNVDYSFLLHFSSNLSQYYIMLEDDVGCSRNFLSSIQQHIRSMTDSKWVTLEFSKLGYIGKLYQSKDLPTLARFLYNFYQEMPCDFLLSHFRRLLMQDKVIRFRPSLFQHMGTYSSFRGTYNRLKDEDFVQELADNPPADVRTNIQVFQTYVPEKAYSQDVEYFWGVSPIGTESFFLVVFREAVRISRVQIHTGSDGKDELASADVELGRVLVTGEPAVDCSGFKTLGSLQHGQFNEEGVQKLLPDAVVCLRIRVTAAQPEWVIISRIQVWTVKEDKTI
The following text describes a protein:
Function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MAAVRMLRTWSRNAGKLICVRYFQTCGNVHVLKPNYVCFFGYPSFKYSHPHHFLKTTAALRGQVVQFKLSDIGEGIREVTVKEWYVKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKKLYYNLDDIAYVGKPLVDIETEALKDSEEDVVETPAVSHDEHTHQEIKGRKTLATPAVRRLAMENNIKLSEVVGSGKDGRILKEDILNYLEKQTGAILPPSPKVEIMPPPPKPKDMTVPILVSKPPVFTGKDKTEPIKGFQKAMVKTMSAALKIPHFGYCDEIDLTELVKLREELKPIAFARGIKLSFMPFFLKAKQQMNPKGNRMMARKMPRKVKQSCSPPTLQTGQPPTTTIELAASLGLLQFPILNASVDENCQNITYKASHNIGIAMDTEQGLIVPNVKNVQICSIFDIATELNRLQKLGSVSQLSTTDLTGGTFTLSNIGSIGGTFAKPVIMPPEVAIGALGSIKAIPRFNQKGEVYKAQIMNVSWSADHRVIDGATMSRFSNLWKSYLENPAFMLLDLK
The following text describes a protein:
Function:
Interacts with glycogen synthase 2 (GSY2); possibly also interacts with phosphatase 1 (GLC7).
Miscellaneous:
MISCELLANEOUS: Present with 996 molecules/cell in log phase SD medium.
Sequence:
MATTTQPQNILMDEPLNLPNNSAHNNNYGNINANIRTFAGMSMHMHPARLNSLEFLHKPRRLSNVKLHRLPQDELQRNTDMNKGMYFNGKQVHAHHPFINSGANFNAHHQDVSKLGEEEDEISPLSHDNFQYESEENGNPSPPIYKKSGELVKSSLKRRSKSLPITPKSIFNKTGSKSKHVNLDHVDTRLLQRSKSVHFDRVLPIKLFNENEKPIDVGKQMVQQDVLNFKHKPLTRLSALNGGSDSVPIEDLLSENNQNEYGDTWLQNPKGVFLFGTNSNNRRNKKKKFKLSDDDSDIENDNDSDDAINRLVRQQDKDQAHLAHGLKNLLINDDDDYLETRTNSAKSGANLFIGNSKRIVGLYNKNFPILSDRNRKSLKLNIFLNLSRGRPVFLQEITLLTGFHNMVIIGKVFVKNIYFDKKIIVRYTWDAWRTFHESECVYFSNANGILPGSNMDIFKFSIDDIHNPNDKDSNISQLEFCIQYLTWGVDRSRKEYWDNNDSANYKIDVVTNETRTGPTTDVNDNYEMKHSLFRNPFH
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MRARSLLRQQASAATLQPLRSVVAIGLRQEFDPHWPLPLPPPLPMNKQKHTLVLDIDETLIHTYAMGLHDDSKDHTRDPALQGVSLIDYNVLLRPHLKEFLEEVNQLFEVVFWTAGTASYCCAVLDALEQQVMQLPRSFYSYVELAKESRKMKSSTSHTNFYALSRTQTLEQQGYMKYLPMLGRKMSSVVMLDDNVRSFPLTPRNGIRIDAFDPDDHVLQRYIFALRRVQKEKPHEMEAALVQCLQQGQQEIARLEKDRALLDVLPVLRAVAQVPAGQDVTKELDHWRDLDYVRCDDFMETMNVRSAVRQQILGVTLPERRSTPIPAQKLGFMNSGFLESANAEMTLHHTRSVRHSKL
The following text describes a protein:
Function:
Sulphite efflux pump required for the secretion of sulphite as a reducing agent. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. Excretion of sulphite mediated by an efflux pump also represents a detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPAPPAYPPARALFNFSPQWFVMPQGTAIISVILHQLHYQFGALRILAKIVWIYTIVLLAMTLFLYILRLIRYPREVCDELRHNLIETSCLASIVITYTTIVQMVALQYGSTHGVAIGVYVLWWIAAFLSTLAVIGIPFVQLKVQPSSFERIPPAILLPVIAALTCAAGGGVICTSTALSPRLQVPVIIVAYLLVGAGISLALGFDAVILFQHFSDQQPSPQKVWQDMILCGPFGQGGFALQILGGAVQKSFPAYARGTLLRAQAAGPIAAVSQFAGLLSWGFATFWWCFAILSILHTLAAQPGGFKSTTFSLGAWSLVFPWGVYTNCAVQLGKIMDSPAFDVWSTALLLLLVIIAIVNTLFTIKGIITGEVLGLEHGWRKEAYQDDKEA
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner. This binding is mediated by the N-terminal A.T hook repeats of orc4.
Subcellular Localization:
Nucleus.
Sequence:
MSSSPFTNLGNLDTEAIYENKENEYQTNITNETSNVQNLSSGNDDQQYPNSTNDDANNGLTASQAKLQDIAAVTLFQDNNISTTTLAPPSPSPLRLNEAPRRRGRPRKYPPKPIDEGSEPIIKRKRGRPPKIKSSSPSTKLDDPLKPKRGRGRPRLHPLPVVQPSVDEGTTQNNLQMGLDEPNIIEGFAEGHANLSELKPKRGRGRPRKIKPEEGSSSQNGLSPLVVLPAKRGRGRPPLHRSEQKIANTPISNNVTVESTGTNLHTHSQLNPENEQSSSEFYSLNPQSEIRKEVVVTDQPLFSTADVPVKRKRGRPPLNKPKILFGTSTENKIDENRPKRGRGRPRLERPSGLPLDSKSQSLFKRKRGRPPKIASGIVPLSAFTRKHEDMLHDSDALSLKHFAITSPNNQQFLNNQQRESAPLLPRKRGRPPKKRQENAEIRNITPGLTDSSVHSSSATPQSESSSPNSVSPLLPSSDRLPLLRQSQFTPPPKKPNFEVAIISPKKSQHKLYPNPVVESVFNDVPYSEIDSQLHTIKSTIAARLCGKSHIPLVGHMDEQTKLYQWVRQTIVLGEGNSVIIVGPRGSGKSVLVDDILSRAAQEINEKSYVVRLNGTYQTDDKLALREISRQLSIELESIESDEALKSEMNFSDTLTKLLATLSHPVDLGIAEDVMTTSAAVIFVLEEFDLFVQHSRQMLLYNLFDIAQSRKAPILIIGLTTRYDCSESLEKRVKSRFSHMVIPMRPPSSLSEFEQILKSVLYVSDEGGKDQIITCWNQRVDELLSDTRSHLHKLVQHHYFASRNLKLLYVDLLFPILSMAPDRPLLADEDFANISLKVSDHKVELVKNLSLLELALLICAVRFEARDIPACNFNSAYQEYRQLHQSSVINAAASGALAHSSRLWGRDVALEAWETLGSIGLIIPVHPSTNVSGALSRQCQLWQPEVDINVVSVGLREHRRLPSHYYRWLKEVI
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MNRPISTLRLVLSATQPRFAPSPAVLRPFVSSTRLYATHHETASPHSQSQATSDLLKGLGNKTGTSSGTQDTVGPFPLGVGPNGRRKTWKSWSDLNIGGKLVRTTQQTGNLTVILFGGALFVVLTFALTTELFAKNSPSVLYSHAIDMIRGSNALDAYLLPPLKFTHSPHSSAPVRGSPPIAHTFIRNPTSGKDHLVISFWIHGRAKDEEETLSWIKQGWRSAVAWGKEGMDMLVGEKPEDVVKEDVEKKERVVVKKEPGTLSRWFGGLNLRSTAGSRVPLAKELPPAGTYTVGEARGEYVKDEAGEFQMLSLIVDIPSSKASYPGRAVIFQSPEAETEGLLGKRIR
The following text describes a protein:
Function:
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, perinuclear region.
Sequence:
MLRQVHDFKGQSFRKLRRACLRRGVLFKDPLFPASDLSLFYKRASPPGLTWKRPREICKDPRLFVDGISTRDLHQGSLGNCWMVAAISCLASEPSLWKKVIPDHVDQEWNPKRPELYAGIFHFRFWRLGRWVDVVVDDRLPVSKDGVLLFCRSATPREFWSALLEKAYAKLNGCYEALEGGNTAEALIDFTGGVSEPLSLDRDFLSLHSNQRKELFHSLAKVHERKALITCSIRPADGETVESVLDCGLVRGHAYGMTAVRKVWLKTCGMSRLFMVRMRNPWGTTDWKGAWSQGSEEWQRLSRAERDKMGLIVRDVGEFWMEFQDFCRYFTDLVVCQLVDRALLWPRSHWRETHCYGEWAPAPATAEAPLSTINQSDAALIPVENDFKDGRTKQEKNREEARLGEKDDRKKGKYDSDKNRNNIRRENVGGFLEVTKMSRCGGCINHRDTFLQNPQFMFEIRGKEEEVLICLQQEDRRMWRKCGGGENLPIGFEVLKVEVNRCSRVQCVLEQAASSIYMDSRSVTWRGTLAPGRFVVLPTTFLPGTTGHFLLRLFTHSHVKLWELREELPPPSLLQCLLPQPSVVTTVHLRRASGLSPPKQTAPHVYAVVRCESEAVRTRLFQEEGNPEFNLRAIFYRRYPDAYISVELWCKGLVWDSLLGEAHLHTCESEKSRNHVIDLRHRRPRSGFIGRIYVETSSSICLTDL
The following text describes a protein:
Function:
Probable transcription factor involved in the regulation of floral induction under long day (LD) conditions. Promotes photoperiodic flowering by repressing GHD7, a major floral repressor. Seems to function independently of HD1.
Subcellular Localization:
Nucleus.
Sequence:
MGSQNRPPPPRKRQPPPPEDHLVTYKRRRSKETQPLPLMANGANSKKDAKAQHWISWRDTLHGFLQSPAISQGGGIQTCIRHALQHNPCLLTNGVVVHTEFKGNPAHSQGEEAKVQHPNGAAGGKVVSADAAIQDAAAAASSEANKAMCNNALFDILVSQKFALLCHLLLGTFHVNKPGDVIDLEKIDAKMRNGDYAHNPALFDDDIQQMWEKFEQVGQEMTGLASNLSTISRVSYQKQASGFSEAEVAEHRIEEISLPGAVHVVTKESTTTVQLAPCDSSHSTIPKRTVPPGRDLCPCDGCGTKVDVEEGLICDECDTMYHFACVKLLNPDIKQVPAIWHCSTCSFKKKELAADTTNNVAHDCLHGGNCVLCDQLELVKTEEEDPKLPIKIELAEEREGSSVSSMGEDNEPDLSTTALSNLCKHCGTCEDDDKRFMVCGHPYCVYKFYHIRCLKTSQLAIEQQKKLGCWYCPSCLCRGCFQDKDDDQIVMCDGCDEGYHIYCMRPARNTIPKGKWYCTFCKIRRAAEGMHKYEDSVLKIHGNSKHACNVNQSKDSEGDGTEK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MPAARGKSKSKAPVTFGDLAIYFSQEEWEWLSPNQKDLYEDVMLENYHNLVSVGLACRRPNIIALLEKGKAPWMVEPSRKRRGPELGSKDETKKLPPSQCNKSGPSICKKPDSSQQKVPTEKAKHNKNAVPRKNKKGHSGKKSLKCNSCGKTFFRSLSLKLHQGFHTGERSYECSTCGQVFRQILSLILHQRVHTQNKSYECDKCGDIFNKKLTLMIHRRSHNGKENFHHEKTSDSCPSLSPHHNNHAIDSIHQCRKCGKVFSRMSSLLLHKKIHNRKRIQKYSACGRGFKKKPVLVHKRICIGKKTHENKALIQSLRQRTYQSENPFTCRKCRKSFSRISALMLHQRAHTSGNPYKCDKCQKDFGRLSTLILHLRIHSGEKQFKCNKCEKVCNRLSSFIQHKKIHKRKKKLIECKECGKMFGGMKNLKVHLNIHSEEKPFKCNKCSKVFGRQSFLSEHQRIHTGEKPYQCEECGKAFSHRISLTRHKRIHSEDRPYECDLCGKAFSQSAHLAQHERIHTGEKPYACKICKKSFTQRISLILHERSHTGEKPYECNECGKAFSSGSDLIRHQRSHSSEKPYECSKCGKAYSRSSSLIRHQSIHSEEMS