lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSYQQQQCKQPCQPPPVCPPKKCPEPCPPLKCPEPCPPPKCPEPCPPPKCPEPCPEPCPPPSCQQKCPPAQPPPPCQQKCPPKSK
The following text describes a protein:
Function:
Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation. Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products. Cleavage of the first strand is rate limiting, while second strand cleavage is rapid. Largely monomeric, dimerizes on the HJ and the first nick occurs upon dimerization at the junction. Efficiently cleaves both single and double HJs contained within large recombination intermediates. Exhibits a weak sequence preference for incision between two G residues that reside in a T-rich region of DNA. Also has endonuclease activity on 5'-flap and replication fork (RF) DNA substrates.
Subcellular Localization:
Nucleus.
Domain:
XPG-N, XPG-I,5'-3' exonuclease domains interact with DNA. Contains a chromodomain that acts as additional DNA interaction site and is required for efficient DNA recognition and cleavage.
Sequence:
MGVNDLWQILEPVKQHIHLQDLSGKTIAVDLSLWVCEAQTVKKMIGTVKKPHLRNLFFRISYLTQMNVKLVFVMEGEPPMLKADVISKRTQTRYGPSGKSRSQKTGRSHFKSVLRECLEMLECLGMPWVQAAGEAEAMCAYLNASGHVDGCLTNDGDAFLYGAQTVYRNFTMNTKDPHVDCYTISSIKSKLGLDRDALVGLAVLLGCDYLPKGVPGVGKEQALKLLQIFKGQSLLQRFNQWIEDPCYSVPQSAPKKVVHCSVCSHPGSPKDHERNGCILCKSDKYCEPHDYDYLCPCEWHQTDHNRHLSEIENNIKKKACSCEGFPFHEVIQEFLLNKNKMLKPITYQRPDLLLFQRFTVQKMEWPSHYACEKLLVLLTRYDMIERKHGRKTSNQLQPIRIVKPRVRNGVHCLEIEWEKPEHYVVEDGDPGKLSLLTMEEASLFEAAYPDAVAVYQKQLSETKGRKQKSMKNKPKGSHLPEADDVINSQSLMTLKPTSKAFPKQNPKINLENSPDPILAQESTSPSLNSFVSPENAPCLNLQEQLVPSPRTLAIKQSKDVSHFLVSECSQPSSSSHDISVITDLQLSTIDWAGTSFSNSPAVQRNTFSQDLASESESSAILPDFEQLSYESEQGTSDSEGSGRDLQQSNPEEQLLSGISALHLHDLPLKERIRIKSSCPQYNVGADAGLESLPLKLKGSCIAYSSSDGSSNFSKDLTGVYLHKESRNSKVLDSRLQENCGANTSLPYSFSDKAVKTSSLQVGLPTAAIPHNPRVAVKTTKNLVMKNSVCLERDSSDEDNAPGSWKSKYTAPEMKHSSQKHSLVHVRDSTHNKLRNPKVESKETKLCNESFKTAEDEENGFSDLGRSPQSFRPCHDKDENSTASWENPLPLRQRLKLRFQNTQSGFYNT
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MEDQIEQAVDIAIQGVGDPAVRQQALDFCNQVKASDEGWQMCLAMFAGDRKRSDAARYFSLQVIDEALGRLNREQLVYVRDHLFAYVRMGSGLSQGQANVNVGQAVSFADDPVHMKNKLGETLAYLFIMTYTEIWDTFFYDFERLLESPENQFGNPRAADLYLRVLNDIHREIGDTLIIRDPAVQSRNNDLKDLIRNRDMARLADSWKKILMYYKDQQLEPLATEIVNNALRVIGGWVSWAELTLIAEPEALEAIFNLLSSPKSRIHACDCLSEIVAKKMYPNAKFQLIQSLNLTSIIHTLSQSADIEFDERVAKLANSIGSELIHIVETESQEFSANCEALLLDMFPLLLRYLGNEYDDTSSQVLPSVGSYLQLVRRDSKREKAKINPNRLTKNTADQYENFPADRTFISDQRHAVVRSILEAVMKKCRYLDDQEWEEDEDGEFCELRQRLKNLQDMCASIDNQLFLDDVCPVISQALSLPPTADWRDIELGMFELQTLSEAMRSGALSTVKTGQNESPATQAFNNLFFQMVASDAVAQCPQPAVHLLFMEIVVKHSSLFSQHNTNLLNRVLEFFVSPLGIQNSESTKVQMRSWILFHKFCKSVKPQIGQVAQLLVDSIRPLLVIQTEDDTDSDDESAGSAFNAQLNLFELSGILVSILDEASATNGVEQTLQPIFTAVEKAIGVSPPNAESITLVHHNLVAIGTFAHGLDGSSNKLPDGILQLFKNSAEVVNVALDRIPDTKVREAARTVFTRLVPILGSSILSEISTLIQILLQRCSHAELADFLGFLGHLLHSFRNDEGVYNMLKSLLSPLCQRVFASLEELSASADAGNTDDKVLKVEIQRAYLMFIMQILRDRMGGAIVEDKQLADSIIKSVIHYASDPTDIYTCRSAASCLTKMIQLWGNGELEAASAEESVFDQGQKIDGFEQIVLEFSGLCWQVPASSGFNLQDAQSKILVTELGNIQKHIYLKKGDQFLSYLVEQYFPQIGVPDNAAKDYVEKLKTLENKDFKKYFSAFVNELVK
The following text describes a protein:
Function:
May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.
Domain:
The SH3 domain binds to PtdIns(4)P.
Sequence:
MAHHLPAAMESHQDFRSIKAKFQASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPQVPDEIYELYDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQDPALRKEKDPQPQQLPPMDPKLLKQLRKAEKAEREFRKKFKFEGEIVVHTKMMIDPNAKTRRGGGKHLGIRRGEILEVIEFTSNEEMLCRDPKGKYGYVPRTALLPLETEVYDDVDFCDPLENQPLPLGR
The following text describes a protein:
Function:
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity).
Sequence:
MISNFLKSNNIKNNSPFRSFCTRYSESHEWIKFNHRNKTCTLGITKYASDQLKSIVNINLPDLNSTITRKQPFGNIESTKTVADLFSDVDGKAVLLNSDVIVDPTIVSHSPEDKGWLIKMESNDFESFNKMMTKSEYGQFLKDINKSNV
The following text describes a protein:
Function:
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Subcellular Localization:
Secreted.
Sequence:
MKLLSPATALLFLAPLAVTATPASFFGYTQDVIAEGAPVRGDNPLEYCSEPSGDILEINSVDLAPNPPKAGTTLKIRAAGNLHERIEAGAYVVLEVKYGLITLLRDTADLCAQLTNVDLQCPLEEGPMVLTKEVDLPSQIPRGRYTVHADVYTKDNKRITCLDAKNIQF
The following text describes a protein:
Function:
The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (By similarity). The carboxylated form binds strongly to apatite and calcium (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MKTLVLLSICALLSVCWSMGAVEPEVVVDTVADTTADAAPADPAAAAAPSSSSSESSESSESSESSESSESSESSESSESNSSSASDSNSSSDSSASDSNSSSDSSSSSSSSSSSSSSSSSSSESTESSESSESSSSSSSSSSSSSSSSSSSSSESSSSESNSADSSASDSPSSSSSSSSSSSSESASDEAAKVVVKRDLASVLLRRRRAAPGGDLTPLQLESLREVCELNIACDEMAETAGIVAAYVAYYGPVPF
The following text describes a protein:
Function:
Binds specific group II introns in chloroplasts and facilitates their splicing. Acts on both subgroup IIA and subgroup IIB introns. The substrates of the subgroup II also require the CRM domain proteins CAF1 or CAF2. Binds both single-stranded and double-stranded RNA non-specifically, but lacks endonuclease activity. Required for plastid ribosome biogenesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MDLSSSFIQVSNPSTYNNYSFSSSFSQFPTQIRLKTPKLSFPNSRNFHVLAVAVDPQQELPKNSPQRLLKELSERKRATSPKKKVPPKRFILRPPLDDKRLAQRFLNSPQLSLKSFPLLSSCLPSSRLNNADKAWIEEYMLEAKQALGYPLEPSDRFGDDNPAKQFDTLLYMAFQHPSCERTNARHVRSAHSRLWFLGQYVLELGLAEFFLQRYPREAPGPMRERVFGLIGKRNLPRWIKAASLQNLVFPFDDMDKLQRKDREPPVKSVFWALFGAIYLCFGMPEVYRVLFEVFGMDPEAEDCQPKLRRQLEDVDYVSVEFEGKKLSWQDVAGYKPPEDALFAHPRLFRACVPPGMHRFRGNIWDYESRPQVTRALGYPLAMTDRIPDITAARNIELGLGLQLSFLHPSKHKFEHPRFCYERLEYVGQKIQDLVMAERLLMKHLDAPGKWLAERHRRVLMNKFCGRYLREKRLHQFIIYSDQVQDAYEHNRRLRNPATTAVQQAIHGLSYTIYGKPDVRRLMFEVFDFEQTQPKAVTV
The following text describes a protein:
Function:
Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
Miscellaneous:
MISCELLANEOUS: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
Sequence:
MHNKQQVKIGIIGGSGLSESEAKKEIITIKTPYGEPSCPYEIEKIDDIEVLFLRRHGQKHSIPPHKVNYRANIYGFKNFGIERIFGVFATGSLTENIPPGSIVIPNQIIDFTQGMRANTFYEEKKVVHIDFTEPFCSEIRHYLLETARKIGINVISHATYICVNGPRLETAAEIKFFKNIGADIIGMTIMPEASLAREVEICYAAVAVVANYAAGISKFPLTVKEVIETMEDSLDAVGFLIKETIKKLPEERKCLCKHALKNASF
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSSKSLDWADDEDYGTGLPSIQTFDNPDGTKTMIEFRIDDNGKKVKVTRVIRKTVITERVQHAVAERKKWKKFGKEAGKNSGVDARTTSVGENVQLRLQLGWTTTKEEEQDEAALAAAKVKAKGSSVVRCRACKGNHFTAQCPYKSIIGPVDEPPLDASPVSSRASGALGEKGRYIAPHLRAGSGRESGDSMFKRERDDSATLRVTNLSDDTREEELRDLFRRFGGIQRVYLAKDKETGRAKGFAFVSYYDRDCAIKARDRLDGYGWNNLILRCEFSKPRD
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MPGQDHNDSNNGNWRRKAPAGDRKDSDAEHKKKRPRRGGRRNNGSKNSEQTQETAAPVAQEAPAPIDAAPVEASKPTNLDYLSDVLFASLDISAQTKRAIVEDLKYERLTNVQNETFPLIIEGKDVLAKAKTGNGKTMAFLLPVIENMVQEGRRQGTIPTLAISPTRELAQQIATEAKRLTKFHELNVACFVGGANIKKDERTLTSSAPIDILVATPGRLVDHLKQNTGRIADRLGKASVLILDEADRLLDMGFRPDVMRIIGYLPKQRQTLLFSATLPASTEELKRVALRSDYAFVDTIDENEADTNAQTEQEYIVCSMKELVPMMEHVLAAHMKLPAYKVMLFFPTARSAQFMAQLFQAAGFPGVLEIHSRKSQAVRTKTAEAFRKGHKVMMFSSDVSARGVDYPDVSLVLQVGLTDRDQYIHRLGRTARAGMKGKGVLILSEFETTLLNQLTDLPLEPSKNYSPAKLVPSQSRTLNVMKNLKNHGDLEKSAQQSYQAWLGFYNSNAKRLKLKSVELVQLAAEYSDMIGLDEVPKLEKRTLKKMNLLGVPGIEPSPYTRDNSGNMTGGRGGGRGGGRGGGNRGGYGRR
The following text describes a protein:
Function:
Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.
Subcellular Localization:
Nucleus.
Sequence:
MQSNMVRKKNPPLRNVASEGEGQILEPIGTESKVSGKNKEFSADQMSENTDQSDAAELNHKEEHSLHVQDPSSSSKKDLKSAVLSEKAGFNYESPSKGGNFPSFPHDEVTDRNMLAFSSPAAGGVCEPLKSPQRAEADDPQDMACTPSGDSVETKEDQKMSPKATEETGQAQSGQANCQGLSPVSVASKNPQVPSDGGVRLNKSKTDLLVNDNPDPAPLSPELQDFKCNICGYGYYGNDPTDLIKHFRKYHLGLHNRTRQDAELDSKILALHNMVQFSHSKDFQKVNRSVFSGVLQDINSSRPVLLNGTYDVQVTSGGTFIGIGRKTPDCQGNTKYFRCKFCNFTYMGNSSTELEQHFLQTHPNKIKASLPSSEVAKPSEKNSNKSIPALRSSDSGDLGKWQDKITVKAGDDTPVGYSVPIKPLDSSRQNGTEATSYYWCKFCSFSCESSSSLKLLEHYGKQHGAVQSGGLNPELNDKLSRGSVINQNDLAKSSEGETMTKTDKSSSGAKKKDFSSKGAEDNMVTSYNCQFCDFRYSKSHGPDVIVVGPLLRHYQQLHNIHKCTIKHCPFCPRGLCSPEKHLGEITYPFACRKSNCSHCALLLLHLSPGAAGSSRVKHQCHQCSFTTPDVDVLLFHYESVHESQASDVKQEANHLQGSDGQQSVKESKEHSCTKCDFITQVEEEISRHYRRAHSCYKCRQCSFTAADTQSLLEHFNTVHCQEQDITTANGEEDGHAISTIKEEPKIDFRVYNLLTPDSKMGEPVSESVVKREKLEEKDGLKEKVWTESSSDDLRNVTWRGADILRGSPSYTQASLGLLTPVSGTQEQTKTLRDSPNVEAAHLARPIYGLAVETKGFLQGAPAGGEKSGALPQQYPASGENKSKDESQSLLRRRRGSGVFCANCLTTKTSLWRKNANGGYVCNACGLYQKLHSTPRPLNIIKQNNGEQIIRRRTRKRLNPEALQAEQLNKQQRGSNEEQVNGSPLERRSEDHLTESHQREIPLPSLSKYEAQGSLTKSHSAQQPVLVSQTLDIHKRMQPLHIQIKSPQESTGDPGNSSSVSEGKGSSERGSPIEKYMRPAKHPNYSPPGSPIEKYQYPLFGLPFVHNDFQSEADWLRFWSKYKLSVPGNPHYLSHVPGLPNPCQNYVPYPTFNLPPHFSAVGSDNDIPLDLAIKHSRPGPTANGASKEKTKAPPNVKNEGPLNVVKTEKVDRSTQDELSTKCVHCGIVFLDEVMYALHMSCHGDSGPFQCSICQHLCTDKYDFTTHIQRGLHRNNAQVEKNGKPKE
The following text describes a protein:
Function:
Functions as a histone H3 'Lys-4' (H3K4me) demethylase involved in the regulation of gene expression. Active on H3K4me1, H3K4me2 and H3K4me3. Repressor of the abscisic acid (ABA) signaling pathway, especially during stomatal closure regulation. Negative regulator of responses to dehydration stress by binding directly to the chromatin of SRK2E/OST1 and demethylating H3K4me3 to regulates its expression. Together with JMJ14 and JMJ16, required for plant growth and development.
Subcellular Localization:
Nucleus.
Sequence:
MLLCDSCNKGWHIYCLSPPLKHIPLGNWYCLECLNTDEETFGFVPGKCLLLEDFKRIADRAKRKWFGSGTVSRTQIEKKFWEIVEGSGGEVEVMYGNDLDTSVYGSGFPRIGDQRPESVEADIWDEYCGSPWNLNNMPKLKGSMLQAIRHNINGVTVPWLYLGMLFSSFCWHFEDHCFYSVNYLHWGEAKCWYGIPGSAASAFEKVMRKTLPDLFDAQPDLLFQLVTMLSPTVLQENKVPVYTVLQEPGNFVITFPKSFHAGFNFGLNCAEAVNFATADWLPYGGSGAELYRLYRKPSVISHEELLCVVAKGNCCNNEGSIHLKKELLRIYSKEKTWREQLWKSGILRSSPMFVPECADSVGIEEDPTCIICQQFLHLSAIVCNCRPSVFACLEHWKHLCECEPTKLRLEYRYTLAELDMMVQEVEKFGGCKTQETKISQRPSSGTKRSIALNKKEGMQVSQARPADKWLLRASKVLDAAFSSVEYATLLKESEQFLWAGSEMDRVRDVTKSLNKAKIWAEAVSDCLSKVEGEVNDDSMKVHLEFIDELLRVNPVPCFNSGYLKLKDYAEEARKLSEKIDSALSSSPTITQLELLHSEVSRSPISLKKHEILSKKISSAKMLAKRAKRYLTDAKPPGIEMDALFKLNSEMLELHVQLPETEGILDLVKKSESARDKSNKVLTGSLSLENVEELLHEFDSFSINVPELNILRQYHVDTLSWISRFNDVMVDVREGKDQRKLISDLSSLLRDGASLGIQVEGLPLVEVELKKASCREKARTVYTARKSLDFIEQLLSEAVILHIEEEEIFVEISGILSTARCWEERASTILENETQMYELKDLVRMSVNIDAVLPTLQGIENTISSAETWLQKSEPFLSATSSMASSPCSMLELPVLKDLVTQAKLLNVQLQEPRILETLLLNCERWQCDNHQLLQETEDLLDNAKIDDGTHSNILPKIMDLITRVDSARRSGLALGLNFDELPKLRTASLKLGWCCKTITLSSSSPTSELLEDVGKPSLQHIQQHLKEGQTLEILPEEYYLGKRLMELKDTGLEWAKRARKVVTDSGALALEDVFELISEGENLPVHAEQELQSLRARSMLHCICLKPYNSRSMVSCSQCGEWYHTYCLKLHWRPKAYVCSACCPLAETTPQIDPARATEPERPSLNQRRTRMVATDAAVNDLKWKTRKHIKRTTKRSPQVHILPWFFT
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. May be involved in the regulation of cell growth. It acts as a suppressor of the endoribonuclease (inhibitory function) of ChpB protein. Both ChpS and ChpB probably bind to the promoter region of the chpS-chpB operon to autoregulate their synthesis.
Sequence:
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGDEIW
The following text describes a protein:
Function:
Involved in C-to-U editing of mitochondrial RNA. Required for RNA editing at 8 sites in 6 different mRNAs in mitochondria.
Subcellular Localization:
Mitochondrion.
Sequence:
MAESLRLLHMTRSVVSFNRCLTEKISYRRVPSFSYFTDFLNQVNSVSTTNFSFVFKECAKQGALELGKQAHAHMIISGFRPTTFVLNCLLQVYTNSRDFVSASMVFDKMPLRDVVSWNKMINGYSKSNDMFKANSFFNMMPVRDVVSWNSMLSGYLQNGESLKSIEVFVDMGREGIEFDGRTFAIILKVCSFLEDTSLGMQIHGIVVRVGCDTDVVAASALLDMYAKGKRFVESLRVFQGIPEKNSVSWSAIIAGCVQNNLLSLALKFFKEMQKVNAGVSQSIYASVLRSCAALSELRLGGQLHAHALKSDFAADGIVRTATLDMYAKCDNMQDAQILFDNSENLNRQSYNAMITGYSQEEHGFKALLLFHRLMSSGLGFDEISLSGVFRACALVKGLSEGLQIYGLAIKSSLSLDVCVANAAIDMYGKCQALAEAFRVFDEMRRRDAVSWNAIIAAHEQNGKGYETLFLFVSMLRSRIEPDEFTFGSILKACTGGSLGYGMEIHSSIVKSGMASNSSVGCSLIDMYSKCGMIEEAEKIHSRFFQRANVSGTMEELEKMHNKRLQEMCVSWNSIISGYVMKEQSEDAQMLFTRMMEMGITPDKFTYATVLDTCANLASAGLGKQIHAQVIKKELQSDVYICSTLVDMYSKCGDLHDSRLMFEKSLRRDFVTWNAMICGYAHHGKGEEAIQLFERMILENIKPNHVTFISILRACAHMGLIDKGLEYFYMMKRDYGLDPQLPHYSNMVDILGKSGKVKRALELIREMPFEADDVIWRTLLGVCTIHRNNVEVAEEATAALLRLDPQDSSAYTLLSNVYADAGMWEKVSDLRRNMRGFKLKKEPGCSWVELKDELHVFLVGDKAHPRWEEIYEELGLIYSEMKPFDDSSFVRGVEVEEEDQWCYC
The following text describes a protein:
Function:
Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to an intron retention; MISCELLANEOUS: [Isoform 3]: May be due to an intron retention.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MSAKSAISKEIFAPLDERMLGAVQVKRRTKKKIPFLATGGQGEYLTYICLSVTNKKPTQASITKVKQFEGSTSFVRRSQWMLEQLRQVNGIDPNGDSAEFDLLFENAFDQWVASTASEKCTFFQILHHTCQRYLTDRKPEFINCQSKIMGGNSILHSAADSVTSAVQKASQALNERGERLGRAEEKTEDLKNSAQQFAETAHKLAMKHKC
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTIVNLDPTNLEFSVFTTEDVRKISVMKVESYRSFDDMGNPVKSGLYDPAMGPCGFGEICATCTRDVSTCEGHFGLIELDLVVYNPFFMRTVSSLLRITCMSCARVQLQDGAKSLLELQLRLADAGYIVEAEEIDVYKTKLQANPHDAIPEEITYYEDLLRKEPYNKLGNTKLSSTIRTAIVNSTLRQESKRCIHCTKMLQRVRITDKKLTIRWTQADKKAFLEEKGNKNPTDEEVKSSTEVVLARESQMFLRKLYEQEGTLLSLLFPVLNSAKHETTQYPTDIFFMEVVPVPPCKMRPVRRANRVPGRSSVMEHAQSVLLRNIFVANATVRAILLGSEGKEKPEGMSDATFGQLKSIHQQAKGATVTEKLFHAWCDLQSNVDQLLDVEKLSGGKQVVTFGLKQLIEKKAGLIRMHMMGKRVNHAARTVITPDPNIGVEEIGIPTRFAKKLTYPVPVTPWNVAELRQWVMNGPDVYPGANMIEDANGRVSKISSTNVTQRQSLAKTLLTPHGAGAESSGDDTIKIVHRHLQNGDILLLNRQPTLHRPSIMAHRAKILGGEKIFRLHYSNCKSYNADFDGDEMNAHLPQNEVARAEAYGLVAVPYQYLVPKDGTPLGGLIQDHIVSAVKLFIRGKFFNREDYQQLVFQALSNKKGNIELLPPSILKPVRLWSGKQIISTIIKNSTPKGMPYINLVGKSKLNNKHWCVLAARPWEYGGTPLRENELSESEVFIRQGELLSGILDKNHFGATPYGLIHCMYELYGGVCSTALLSSLSRLFTYYLQWEGFTLGVRDILVQSKADRKRSRIIRECRAVAGHEAATSALELPASVSRDELAQRMREAYAKNPKFRAILDRKYKTVLDTYTNRINNACLPEGLISKFPENNLQLMVQSGAKGSTVNTMQISCLLGQIELEGKRPPLMISGRSLPSFADFDTSPKSGGFIDGRFMTGIQPQEFFFHCMAGREGLIDTAVKTSRSGYLQRCLVKHLEGLSVHYDMTVRDSDGSVIQYMFGEDGMDIAKTQFIGNEKQTRFLDMNRDVIVQPEVLKRLQTSRDEDPLNEALKKHVKKMKRWTKQNGGGPTEVQRVRTSAFALFSADHAEALRAELPNPDKMKKSGRTKLTEKLLKRWAKLEPAARREYVRRAAHCPDPVGAVFPPDSHYGVLSEKLEAMVRKYKRTEQPLHNIDELMQVKGSASLAAPGEPVGVLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMCAAAEIKTPSMEIPFLPHRKPERLKAVAEKLRKSLNRVTVADVLETINIKSKLVVHPSRGMQHTIRFNFLPQDAYDHDYCVTPSGILRHMSRKFFKAMFAAIRRAESAKNVLIDTEMQEGKSKKHKKGADTEEDDEIDRQEPEKVDKSEKAVYSDSDSDSDDGGTPAVDGDASDAKNRGKTKDEHDYDEDDENDADADAAGASSDDSGVSEDEQEDEKEAQKQPAAGGKQKKKLPSAKASRSRCIEEALIEEYEKEQDELGQELAAMPGAEETLNEAEETMFLAQVNAQVSKFQHDRVAKRWCQIVLHMPLKLKEIDFTKVLRDVAAKSVIWEVPRIKRAITYMQNDQLYLRTDGTNMSAMTAHAKVLDLNRLYTNDIHAMANRYGIEAASRVIVKEIQNVFSVYGITIDPRHLLLVADYMTASGRYQAMNRMAMESSVSPLQQISFESSLKFLKEALLKGTNDRLESPSSRLIVGQPCKVGTGSFTLYSSALKDYAEASMA
The following text describes a protein:
Function:
Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane (By similarity).
Subcellular Localization:
Vacuole membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
Sequence:
MRGSEASGPGAIFGAPSTLTTSVIRNPTSFLSSSTPLPSTDADVIAQNVEHVLLSLTSHNDGGLVGVSGNSSGSTGKGILIGVLSAFGSATVAVLVLAIFFFFKYTRRGRIFLDRIGRPGEFDDEQAFAREEAEALEVMDDMARSEYMRAKSFVEANPPESMQTDISLSQFLAIQEKGVSAWEFQPELEIANCFVEGRTEIEFYDSECSVQTNLPVPKQNDVYYWEAKIYEKPESTLISIGMTTKPYPLFRLPGFHKTSVAYLSTGHRRYNQPFSASPYGPALAQGDVVGVGYRPRSGTIFFTRNGKKLEDVVHGAKTQNFFPTVGANGPCTVHVNFGQMGFVFIEANVKKWGLAPMTGSLAPPPPYGSEQGSILLESGRESAAQISQRVYQDARTSSTVRIPPSRSPGPVRSPTDISLAPLAHIPSHEDVGEGSSHANTIADEQTALLNPTDLDQVPPPEYSSPDGSRRGSDITGDLPNQSSPPIPSYDAAVGNQADNTLRPDGDH
The following text describes a protein:
Function:
Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis.
Subcellular Localization:
Cytoplasm. Early endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MAAAAPVAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMDEAPLTDVRDIKDT
The following text describes a protein:
Function:
May act in meiotic drive.
Miscellaneous:
MISCELLANEOUS: Although the gene is capable of encoding two isoforms, RNA sequencing data show no evidence of alternative transcripts.
Subcellular Localization:
Spore membrane; Multi-pass membrane protein.
Sequence:
MSGSYAPIEDSADELSVHSGNDNEIDLEKGLLPKCNTGNGGTTPCSEPPHYDSDAVVEMDMYENNIYMRTFKLRPFAKSGVTNSSNVVFQMKTYENNRHMQTFRLRPFAKNGVTNGVKLAQSLFLLLPFNFIFFACLFFRKASFTDFSLMGWILFGIWCLTCFLSSFILYAYHESWTKFARERSQEFSLILFGLLFPGIVTMVVFYALYMRSMYG
The following text describes a protein:
Function:
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
Domain:
The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.
Sequence:
MRFTRLSLSNFKCYADAAVSLDPGVTVIHGLNGSGKSSLLDACFFALYGTTALDTTLADAVTIGAETAEIDLHFEHAGGDYHVHRRIRASGGRAQTAACVLETPTDRIDGVTDVEAHISGLLRMDAEAFVNCAYVRQGEVNKLINAAPSTRQDMIDALLQLGKLEEYRQRAGDARLGVEDVKSNVEGQLDRLADQIADKEAADPHDRLASHNTALAEVTADIEHFEAEREQARQTRDDAADVLERYEESRTALADVEETIADVREAVAEAERERETLADRVSDHRERASDLDDEAAALAADLGLDDPDAEDASAERDAVADQREAVAERVREVAPAVSRLTEQADSAADDAATLDERAETLREEAAALDAEADDAAAKRDDAAARIEALDADIEAAMAAFDDAPVAFGAAEAFLDDATAERDELRERVATLRADRQSAADRVAEAEALLDEGKCPECGQPVEGAPHVERVTDDRERVAELDAELADVEDELDAVAQRVDRGESLVAAEDRVDDLEQQRERAVERRDEQADIADAKRDQAAEKRDRAADLDAEAEDARADAAAKRDAADEKRETLAALNADQTALKERLDALADLVDRLEAAADAREAAQRLAEKRAALAAQNEQRRDRLSELRERKRTLDSEFDADRIETARADKDRAEDYLEQVEPKLQALREDRDDLQAKIGAAENAIAELESLREEHERVQSRHQDLQAVHDEVTALETMYGELRAELRQQNVSKLERLLNETFELVYQNDSYARIELSGEYELTVYQKDGEPLEPAQLSGGERALFNLSLRTAVYRLLAEGIEGDAPLPPLILDEPTVFLDSGHVSQLVELVESMRRLGVEQIVVVSHDDELVAAADDVVRVAKDATSNRSRVSTPEHI
The following text describes a protein:
Function:
Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Displays no proline racemase activity.
Sequence:
MTIHGFTCIEGHTEGMPVRMVIDGAPTLQGATMNARREDFVAHHDWVRRTLMLEPRGHAHMSGTIFYPPVSDNADFSLLFIETSGCLPMCGHATIGSIAFAIEERLVVPKRPGTVTVDVPAGQIVARYQTDGERVTSVRFTNVPSFLLKRDVEIAIPALGTLAVDIAYGGNFYPIVEVQPNFPGCEHFTPDELLAWGRDVQRAVGDALEVVHPDNPAIRGVRHCMWTGKPIADDAHGRAVVIAGDSLVDRSPCGTGSSARVAQRFARGWLKEGEAYCHESLIGSRFIGRVESTVRLESGVDAVLSSIEGRAWVTGRAQYRVDPSQPYALGFSLQEFVN
The following text describes a protein:
Function:
Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEGNIKLLKKVGLKITEPRLTILALMQNHKNEHFSAEDVYKIFLEQGCEIGLATVYRVLNQFDEAHIVIRHNFEGNKSVFELAPTEHHDHIICEDCGKVFEFTDNIIEQRQREISEKYGIKLKTHNVYLYGKCSDINHCDENNSK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MMDSFKPLHSLGFVGVKPDTALKTEQRPALCKSDLQDTKTKQLPDSHGHKIESPVVGPFVESSKDMCAEDLHREEIHGNQMHLAKKPGVGNVQAAQEVEPTRSYLQENCRTELCMETSQEKREKTPPPPFSTGSCKQEDSYTPGQSTDWTVRECVIKDEYEWDSCQQDDSPENWMLPDHFNQPDYVRCNTVQHAEDTPAQDEGGGSLSWGDLEHNQKHRFQPTNPEEYGDYVCTICGDKFSDKAELVVHSCKAKLYLSTPCEENLAWGSQYITNLIGPNGKMLFVCGDCGKSYAYRSHFVIHQRSHTGEKPFPCTECDKSFTCTSHLIAHQRTHTGERPYVCPECGESFTQSSTLIIHQKIHTGEKPFECNECPKSFSRHSHLVLHQRTHTGEKPYACTECGKRFSSLSNLTAHHRTHTGEKPYLCVECGKGFTQSSALVLHKKIHTGEKPYECGECGKSFSRTSHLTLHQRTHSGERPYVCLECGKTFLRSSHLVLHQRTHTGERPYSCNECGRTFTQTSHLVKHQRSHTIERTPSPTMGEAISPMRTANVFIAEYRGVCQCGISVRCYSLHQT
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MSSANFLDFQYNLSKRKFLRKPSHVFSFRDRQNSGVSPSFEPNPNEMKRVFDKFDSNKDGKISQPEYKAILRALGKGNMVGEVPKIFRIADLDGDGFINFKEFMEVHKKGGGIRTIDIQNAFRTFDLNGDGKISAEEVMEVLGRLGESCSLEDCQRMVRAVDTDGDGVVDIDEFMTMMTRSMKTCLEN