lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function. Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner.
Subcellular Localization:
Cytoplasm.
Sequence:
MAYYNLWNQIQVYGNFMNKHQKPVLTGQRFKTRKRDEKEKFEPTVFRDTLVQGLNEAGDDLEAVAKFLDSTGSRLDYRRYADTLFDILVAGSMLAPGGTRIDDGDKTKMTNHCVFSANEDHETIRSYAQVFNKLIRRYKYLEKAFEDEMKKLLLFLKAFSETEQTKLAMLSGILLGSGTLPATILTSLFTDSLVKEGIAASFAVKLFKSWMAEKDANSVTSSLRKANLDKRLLELFPVNRQSVDHFAKYFTDAGLKELSDFLRVQQSLGTRKELQKELQERLSQECPIKEVVLYVKEEMKRNDLPETAVIGLLWTCIMNAVEWNKKEELVAEQALKHLKQYAPLLAVFSSQGQSELILLQKVQEYCYDNIHFMKAFQKIVVLFYKADVLSEEAILKWYKEAHVAKGKSVFLDQMKKFVEWLQNAEEESESEGEEN
The following text describes a protein:
Function:
May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MFLQSTENDMRFKPSRDRLYSARCCGCCHVRTGTIILGTWYMVVNLLMGILLTVAVTHPENVPTVDLQYEVIEHYFASDRMSENACVGFAISLLMLTISAMMVYGAITNRDGWLIPFFCYQLFDFALSCLVAISSLTYLPRIKDYLDQLPDFPYKDNLLSLDSSCLLLFVLIFFAILIVLKAYLINCVWNCYKYINNRNTPEIAVYPAFETPPQYILPTYEMAMTMPAKEPPPPYMPA
The following text describes a protein:
Function:
Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MQVKNKAKLKDKNVAITLVPEDSEDLWYLYNLLKKGDTVQLVTHRNVKKGNQAQITKGKSKMEKIVVRLKLLVEDIDYIASDQTMRINGKSLVQQEYIPLNSFHTAEVELNKELTILKDNWDEYDMTLLNELCSIENKADIGAVVFQEGVAHICYVADSMTVLKAKVEKSIPRKNNEYGTRDLEKAMNSFFNMIISSMTRHFDFEKLKVVILASPGFLAKTLYDRLIQECLNLQNSGKESKVYSSILKNKSKFLIAHASTGYLQGLEEVLDDPQTKKRLADTKFLEESEALQRFQRALNDDDGRAWYGLEEITKALNMDAVRYLMVSDALFRSDDIEERRHYIDLTEQAKTLGAKVYIFSSLHESGEQLNQLTGIAALLKYPIPDLDDSDEED
The following text describes a protein:
Function:
Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MLPFRRLPSTTVGQCFTLVRSFTGGITQWAKKAEQLESEEPAAEELPLTFVDDDAESTEAREARIAALRNKSRLLPQHRNMLHGVLPYEQSQSWIHDTVKYKRMMLGRYGIDGSKVDPRVCFPTKKEAYERAEYERVAFPFSLKQMMDANESERKARKAQIEAREAEVARKLEKLDQWTADLNARIAKKEAEARAAKERKDRLVEEVRRHFGFKVDPRDERFQEMLALKEREDRKKVKEAKRKEKEEKMMEKLQKKTAQLEADIEVPSGEKTKQ
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.
Sequence:
MSSTGALEACALEDMYEIERVLSWIQELDLKKIALQFPDELLKDAPDVALKIELSSKIEVHILGDTSYGSCCADVQAASCLGAQGLVHFGPACLSQQEKLPVLYIFEKVNIEVNPFLTAITTVLPEQENYIIASDLKYNQSTVTELLALNKTVLYLEPNVVSQRLPSTEHLTVSGRSCHQLLPPGTPLENFVLVYIGEEGLTLTNLMFVLNKCTFFTYNPIDCTLKKECFNVNQQLRRRYFLTQKAKDAQLVGILVATLGVADHLKIIEHIKVLAKNAGKKCYTFVVGKLNPNKLANFPEIDVFVAVACPENSLINDKEFYRPVITPYEFEVAVNSARSWTGDYITDFRQLLPDGGGFVLLESVHREQETDVSLISGQLNRVGLDCNEESVFNSSGDICLRDQNQSVLPVGSAFLKQRKWSGLEPHVGETPVRIAHLGRKGLAASYSGEGEKVINQDNTLEKSEVPQ
The following text describes a protein:
Function:
May play a role in a redox process involved in nitrogen fixation.
Sequence:
MSKVSKTAMPAGAGRGAAKKELPEHFKSYKHVWVFVELERGQVHPVSWELMGTGRGLADRLKVNLAAVVVGPEGQHTRNAALEAFCYGADLAYLVSDNVLSDYRNESYTKALTELVNTYKPEILLLGATTLGRDLAGSVATNLSTGLTADCTTLDVDADGSLAATRPTFGGSLLCTIYTLNYRPQMATVRPRVMPMPARVMRDAARIVVHPLGLVEDDIVTKVLSFLPDRDAETSTLAYADVVVAGGLGLGSPENFRLVRELAALLGAEYGCSRPLVQKGWVTSDRQIGQTGKTIRPKLYIAAGISGAIQHRVGVEGADLIVAVNTDKNAPIFDFAHLAIVSDAMQLLPALTAAFRARLLPDSRARIAV
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MKIFVKTLKGDRFEIEVNLEDSVVDVKKNIETVMGVTAEEQMLIHKGKVLKDETTMEANNVSEKSIIGVIKRKAASTATSTSTETPTEGASAGASYVASERVSESSIQKILGMVGEGWDRYMVTSALCLADDDVNKALEYLYFELPRQIEDHYIAEGAQDQTQEYENPTEEDELRFFDYLNGSPEQEYLRALARSDPGIVKDFVEMLEEQDPPIFVLIQDNKALFLRSLLEVQGGACGNEMEQAHEHQAVQTNEPNNGGDGDNQVGGESEETKVEELQADQTNKPNNGVDGGNQVVGESEETKAEVANAEDNELIEQLEALGFERGDAEVAYFACNKNVQEAANNLLGHKHESQE
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MATTALSRDPFLGVNFPSQKPLSQRVVRHALAILHLLTNQGDMLVPTDSGSSLELGKRNHEKKVKVDQVMKLVLGIIHLLNEGQMEEASVSFSAEEWGSLEKEQRDLYKDLLMENDETLRSLNSFSVKTESCSRAEREELHIKDPPEDPPPDLHPNTFPCTDAPGRGIKATPLADVMGTSYSMDPYQGADSATFPKLLGPGTPTSIIPNPPTNSSAMEHSIGTYPSNPAMEQSIGTYPSNECSVSTYPNHSGTEGPVTTYSDTCISADPISSSPRTLSESCKDSYMDSYPSTMTEPSMIPASGTACGALISHFIGTYPGSSPEAFPGNMAAIHIKQEGSPPDGPSGKWTVAAAPYSPANGSGGGPLKKQGKVAKKPPPRAPGHSSEKQREARWSPDKAQTVGENPRGHAGRFDSRAPHRKHPGKKPFECMRCDKSFKCRSHLVMHQRVHTRERPYVCTECGKSFTQSSNLFRHQRGHRGERPYVCTECGKTFTQSSYLLIHQRTHTGERPYSCTHCGKSFRVSSTLVRHQRVHVGEKPFGCTKCGKRFTQSSYLLIHERTHTEERPFSCTVCGKGFKVNSSLLRHQRLHLGEKTHTCAHCGQGFPELSRLLSHQQSHFQGGSPGGPSVGLPYDWE
The following text describes a protein:
Function:
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
Subcellular Localization:
Cytoplasm.
Sequence:
MKPLDLNFICQALKLPMPSESKPVSRIVTDSRDIRAGDVFFALAGERFDAHDFVEDVLAAGAAAVVVSREDCAAMDGALKVDDTLAALQTLAKAWRENVNPFVFGITGSGGKTTVKEMLAAVLRRRFGDDAVLATAGNFNNHIGLPLTLLKLNEKHRYAVIEMGMNHFGELAVLTQIAKPNAALVNNAMRAHVGCGFDGVGDIAKAKSEIYQGLCSDGIALIPQEDANMAVFKTATLNLNTRTFGIDSGDVHAENIVLKPLSCEFDLVCGDERAAVVLPVPGRHNVHNAAAAAALALAAGLSLNDVAEGLKGFSNIKGRLNVKSGIKGATLIDDTYNANPDSMKAAIDVLARMPAPRIFVMGDMGELGELGEDEAAAMHAEVGAYARDQGIEAAYFVGDNSVEAAEKFGADGLWFAAKDPLIQVLRHDLPERATVLVKGSRFMQMEEVVEALEDK
The following text describes a protein:
Function:
The glycine cleavage system catalyzes the degradation of glycine.
Sequence:
MTALKTTPFHQAHQDAGAKLVDFAGWELPIHYGSQIAEHEAVRTDAGMFDVSHMLVTDVAGANAKAFFRKLIANDVAKLAFVGKALYSALLNDNGGVIDDLIVYRTNEAETQYRIVSNGATREKDTAQFHKVGQEFGVAFNPRYDLGMLAVQGPKAIEKLLTVKPEWADVVHNLKPFQGADLGNDWFVARTGYTGEDGVEVILPGTEAVAFFKALQQAGVQPCGLGARDTLRMEAGMNLYGNDMDDDTSPLEAGMGWTVDLKDESRDFVGKAALLALKEKGVAVKQVGLLLEKGGILRAHMEVLTDKGQGETTSGVFSPSLKQSIAIARVPKDFDGDTAKVLMRGKEVDVRVLKLPFVRNGQKQFD
The following text describes a protein:
Function:
Might be involved in transporting short diacylated glycolipids to the cell outer membrane (By similarity). Overexpression induces expression of sensor protein kdpD gene at low K(+) concentrations (0 and 250 uM, tested in M.smegatis).
Subcellular Localization:
Cell membrane; Lipid-anchor; Extracellular side.
Domain:
Forms a U-shaped beta-half-barrel with a small hydrophobic cavity which is large enough to hold a single diacylated glycolipid molecule.
Sequence:
MNGLISQACGSHRPRRPSSLGAVAILIAATLFATVVAGCGKKPTTASSPSPGSPSPEAQQILQDSSKATKGLHSVHVVVTVNNLSTLPFESVDADVTNQPQGNGQAVGNAKVRMKPNTPVVATEFLVTNKTMYTKRGGDYVSVGPAEKIYDPGIILDKDRGLGAVVGQVQNPTIQGRDAIDGLATVKVSGTIDAAVIDPIVPQLGKGGGRLPITLWIVDTNASTPAPAANLVRMVIDKDQGNVDITLSNWGAPVTIPNPAG
The following text describes a protein:
Function:
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
Subcellular Localization:
Secreted.
Domain:
The FZ domain is involved in binding with Wnt ligands.
Sequence:
MWRGLPALALAALLLLGRAPAGRAAACEPVRIPLCKPLPWNMTKMPNHLHHSTQANAVLAMEQFEGLLGTNCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARAGCEPVLIRYRHAWPESLACDELPLYDRGVCISPEAIVTAEGADFPMDSNNGNCRGTGIERCKCKPIKATQKTYLRNNYNYVIRAKVKEVKTKCHDVTAVVEVKEILKSSLVNIPKDTVNLYTNSGCLCPPLSANEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDQKLRHLGKGKGEPGQSDSALKTGKPGNARQTRS
The following text describes a protein:
Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MESTSQDRRATHVITIKPNETVLTAFPYRPHSSLLDFLKGEPRVLGATQILLALIIVGFGTIFALNYIGFSQRLPLVVLTGYPFWGALIFILTGYLTVTDKKSKLLGQGVTGMNVISSLVAITGITFTILSYRHQDKYCQMPSFEEICVFSRTLFIVLFFLPSDVTQNSEQPAPEENDQLQFVLQEEFSSDDSTTNAQSVIFGGYAFFKLTLSRSPLVSQPGNKGREFVPDEQKQSILPSPKFSEEEIEPLPPTLEKKPSENMSIQLDSTFKQMKDEDLQSAIVQPSQMQTKLLQDQAASLQVFPSHSALKLEDISPEDLPSQALPVEGLSEQTMPSKSTSSHVKQSSNLTANDLPPQGILSQDTSSQDMLFHDMTSQDMQSLDMLSQDTPSHAMPPQDIPSQDMLSQALSAHAILPEASTSHIVQFPEIQHLLQQPPDLQPENTEPQNQQILQMSYQDIRSEVMEETKEWKSEEELHRRKSSRRHSLNQQTKALQYLRRHSLDVQAKGQKSSKRHSLDQQSKGWQSPKQKSLDQQIKDWLSPKRHSVDKQAQLNQTKEQLPDQQAEDQQAKGEQYPEGQSKDGQVKDQQTDKEQNSKKQTQDQQTEDQPAQEKKSPKGQFQNVQAEGQQAQVEKVPKLLCQDSESQIQQYQFWQFHKGNLQAGQPRTVNLLAKNPLTG
The following text describes a protein:
Function:
This protein inhibits independently subtilisin and T.castaneum alpha-amylase but not barley alpha-amylase.
Sequence:
MVSLRLPLILLSLLAISFSCSAAPPPVYDTEGHELSADGSYYVLPASPGHGGGLTMAPRVLPCPLLVAQETDERRKGFPVRFTPWGGAAAPEDRTIRVSTDVRIRFNAATICVQSTEWHVGDEPLTGARRVVTGPLIGPSPSGRENAFRVEKYGGGYKLVSCRDSCQDLGVSRDGARAWLGASQPPHVVVFKKARPSPPE
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
Sequence:
MASLCSNLHPPFLSLVLPRQNTVSSWFFINGRVKFNLKKVSTTRRITCKKASSRGPDNDRFVRSKIEKTVAKQGDKKFVHEGLITESLPNGMFRVLLDNQDLILGYLSGKIRKNFVRVLPGDRVRVELSPYDSTKGRIVYRLRNKDASG
The following text describes a protein:
Function:
Serine protease that functions in the melanization-mediated immune response. Cleaves and activates prophenoloxidase (PPO), which is required for the activation of the prophenoloxidase cascade probably following the recognition of pathogen-derived products.
Subcellular Localization:
Secreted.
Domain:
The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.
Sequence:
MTSYNRSVAWLTVCVLLALHIGGSHQQQQQCTTPTRLRGRCISIYECDSILDYFKQRILTWEEREFLRKSQCTGATSGRQPFVCCPGNGSKPVVAPATTVPAGTASTTPAGPAATAPSGDAALADQLVGGLLPNPKKNECGVSIGMRIYGGQNADIDEFPWLALLQYENRKGERKYSCGGSLINRRYVLTAAHCVIGEVERKEGKLVSVRLGEYNTKTEIDCVTEEQEEICADPPIDAGIESVIVHPGYQDMAHADDIALLRLAQSIEYTSFVQPVCLPLTDFRASKTGEVNFVTGFGRTLQESRSAVKQKLGIKVYDHARCQEKYATKNSSITTNQLCAGGEYAKDSCHGDSGGPLMKLQKVWYLEGIVSYGNRCGLEDWPGVYTHVPAYMAWVRSNIKE
The following text describes a protein:
Function:
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Sequence:
MISVVLAESALELVPSELKHHQSVISHARKLGKLSSEILLDNSWHFAAMKGIINELKRGRPDLVHFSILEATTIPLYLKNKIKLYVHTIDDKVIYFGQNVHVPKSYHRFAGLIEKLYKEKKIIANNETLLEIKNKTFSELIDEINPSKIIGFSTKGTENSYEKIVSEINTDYCLVFGGFQKGHFSDSIEKKFAQMYSVGNEPFEGHTVVARMLYEYEKTIFM
The following text describes a protein:
Function:
Catalytic component of the DNA-directed RNA polymerase (RNAP) that catalyzes the transcription in the cytoplasm of viral DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Forms the polymerase active center together with RPB1 (By similarity). Part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).
Miscellaneous:
MISCELLANEOUS: The binding of ribonucleoside triphosphate to the RNA polymerase transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion coordinated by three conserved aspartate residues of the two largest RNA Pol subunits.
Subcellular Localization:
Host cytoplasm. Virion. Note=Found in association with viral nucleoid.
Sequence:
MEPLRPQITYGPIETVDNEELTEADMLSFISAAVNSTGLIGYNIKSFDDLMDNGIPQIVKQMFNVDITYKDQRDHTEIDKLRESVQIQFNFTDVNIERPQHRNYSQGNKINLLPNKARLCGLSYSGPVNLAAEVILTAHYSNGRQEVKRASIPPFQVSTFPIMRGSNRCHTHHLSKTAKKEIGEDPNEPGGYFIARGGEWVVDLLENIRFNTLHIHYHTMQQGNNEIIRGEFISQPGGAFENSSQIIIRYMTTGAITIEINSTKFSKLRIPWYLIFRMFGMTGDDSIIEQVVFDLESNSPVNTFMIEILEKSIHVLDPIFQPVQHEPNREKIIQFLSEKVSKFVSNPSAYKSDENAVQYLNERQLTILDKILLPHMGQTADTRVRKLRFLGLLIHKILLVIMNVFPPTDRDSYRTKRVHGSGVSLAKAFKAIFNTSVIAPIINGFKELLKQTAFEELTQRNIIEAFSAALSKNTASDLNRSMEQSIISGNKTIMVRQRPIVNRVSTQSLERKNLLNTISALRTVNTHNTTNASKQTERADMMRRVHASYPGYICVAQSADTGEKVGMSKQLAITANVCTAGEVLSLKQRLLSDPAIQQLADVSNKDIVRKGLARVFINGEWIGCCTNAFELAQRYRMFRREGKIVHPHTTIYWDSMVDEVEFWLDVGRLTRPLLIVDNNIEKYNQACYKAAEARKKGDKDWEKHKIPFIQNTRFTSQMAKDILAGTLTLEDLVAQGICEFITPEEAENCLVAFSIIELRKHKHDVTRRFTHVDVPQAILGLAALVSPYANCTQPARVTYETNQGRQTGGWYCFSWPYRVDMNRFFQFYNEMPLVKTIAHNYVIPNGLNTIVAYMIYGGYNQEDSVIVSQSFIDRGGFAGTFYREEKVELESDIESFGKPDPLITKNLKPGANYEKLVDGFVPVGTVVKKGDIIIGKVAKIRGEKDELNKYIDRSVMYGFDEPAVVDAVMRPHGPNDEIFGLMRLRYERNLNIGDKMSSRSGNKGIAALALPTSDMPFTEDGLQPDLIVNPHSHPSRMTNGQMIETTVGLANALQGVVTDGTAFLPINVQLLSERLAQEGLRFNGCQKMFNGQTGEYFDAAIFIGPTYHQRLQKFVLDDRYAVASYGPTDALTGQPLDGKRSHGGLRLGEMEHWVLTAQGAMQTIIEKSHDDSDGCISYICRNCGEPAIYNASHPIYKCMNCDVQADIGMVDSRRSSIVFQHEMRAANVNITSVLSPRVFQPA
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MTRGVPRLAVAARHFSTAEAAGVKVAAQDGQSPISDLSVVLRGGSRYATVPGVSHILEKFAFQNTVPKSALRFVRELELFGGKLYTHTTREHIVLRTQFLKQDLPYFVDAFANVLKETKFQQFELTERVAPVAELDLLKRESDPAFTALEAAHEVAFRTGLGNSVYAQGYSPVTLEDVKEFARQVYAKQNVAVVGNNVVPADLQQLVGTAFADLQEGSKVTQAGTTTLHGGEARVRTSTGNALTIALPIAEPKPVYHALASFLGGPASMPWSVGASPLAQATVGTHTSVKATYHNYGDAGLFAITIKGDSPAEISQVAHKAVQALKDTGAEVTEEQAARAYAKSKFAAAEAFENPDSSASVIGMELLSGVSRIAPENVQKFTPAELSEAAAQLSASAKPVVAAVGQVHALPFADELF
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Specific receptor for geosmin, a microbial odorant that constitutes an ecologically relevant stimulus that alerts flies to the presence of harmful microbes and induces avoidance behavior.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFKVKDLLLSPTTFEDPIFGTHLRYFQWYGYVASKDQNRPLLSLIRCTILTASIWLSCALMLARVFRGYENLNDGATSYATAVQYFAVSIAMFNAYVQRDKVISLLRVAHSDIQNLMHEADNREMELLVATQAYTRTITLLIWIPSVIAGLMAYSDCIYRSLFLPKSVFNVPAVRRGEEHPILLFQLFPFGELCDNFVVGYLGPWYALGLGITAIPLWHTFITCLMKYVNLKLQILNKRVEEMDITRLNSKLVIGRLTASELTFWQMQLFKEFVKEQLRIRKFVQELQYLICVPVMADFIIFSVLICFLFFALTVGVPSKMDYFFMFIYLFVMAGILWIYHWHATLIVECHDELSLAYFSCGWYNFEMPLQKMLVFMMMHAQRPMKMRALLVDLNLRTFIDIGRGAYSYFNLLRSSHLY
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Sequence:
MANALKLGLKSSVFELCACKASNAQGYTNAVVVAPRLSAKGWSKKELAAWTRVQVTGSMEVHRHVTKHQHFSEPLKGKRRAAVMRAASVEAEAGPQVVVTREQGKNGKLVKALAAHGIKCLELPLIEHREGPDVHRLPQVLKEETWDWIIITSPEAATVFLEGWRAAGRPKVRLSVVGAGTGTVLEEAPEADDLRPEFTPSKATAKVLAVEIPEPQPGSRVLYPASVKAGSDLQEGLEARGFKVTRLNTYSTETVRTVDPNALAAAADAPVATFASPTAVKAWVERVCQGDVKRWSGAAACIGNTSAVAARNAGLDKIYFPDSPGIEGWVRSVREALSAVET
The following text describes a protein:
Function:
Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively. Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate. May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable).
Miscellaneous:
MISCELLANEOUS: Mediates the efflux of cationic compounds such as the model cations, tetraethylammonium (TEA), the neurotoxin 1-methyl-4-phenylpyridinium (MPP), the platinum-based drugs cisplatin and oxaliplatin, the drugs procainamide, acyclovir and topotecan, or weak bases that are positively charged at physiological pH, such as cimetidine or the antidiabetic drug metformin.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the plasma membrane; at the brush border membranes of the proximal tubules (kidney) and at the bile caniculi (liver).
Sequence:
MEAPEEPAPVRGGPEATLEVRGSRCLRLSAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNVPRSGNSALPQDPLHPGCPENLEGILTNDVGKTGEPQSDQQMRQEEPLPEHPQDGAKLSRKQLVLRRGLLLLGVFLILLVGILVRFYVRIQ
The following text describes a protein:
Function:
Alpha-ketoglutarate-dependent dioxygenase that in vitro catalyzes the oxygenolytic release of sulfite from hexylsulfate.
Sequence:
MTTFIQNPTQQLQLRKLTGRIGAEISGIHLSSELDSSTVQFIHDALLEHKVLFFRGQQHLGDTEQEKFAELFGSPVKHPTVPAADGTDFIFELDSQKGARANSWHTDVTFVDAYPKISILRGLIIPETGGDTTWANTETAYEDLPELLKQFAEQLVAVHSNEYDYGGPKQNVEPEQLERLKKVFVSTKYETEHPVVIVHPETGKKSLLLGHFFKRLVGFSQSDSQLLFNILQEKVTRPENTVRWQWQEGDVVIWDNRSTQHYAVNDYGDQHRVVRRITLAGEVTTGAHGLKGKTTLPKDLSAEQLEKAKLHAVLNAN
The following text describes a protein:
Function:
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLKKKFLEKSKKVAEERINILMNLAEKESNSGKTERSKNYVLLGKKIAMRMRMPYPKEWKRRICKNCGSFLIYGKNARVRTKAKNYPHVVITCLECNSITRIPIKTAKK
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MEDPVCFLELLVPSSPFLLHSVLSRRQAPIQLQREPDAFSLSDFLFGYHGIILNCSVIPGNLSKHSIWDNICSIYRGIERCKEFKDAPPPVKSVRLLELLLRLVRPRSNVFDNMLVVTAPANLAGSMEEHEWMLDCLDIVVASPQEARKLKASMTLLALVLVDDDNPEFFSRVMDLVESLLFFSLPVSLKPSPCRPAKVDVINYLAPWEAINMSKELLRAIELSLPEAACCSGFLDPCFCNAVQNFSVFRRNVVCQDWSGILAFMPGLIPDSTSTASIVLAPGHRIPQLLELLQAFVDVLGLFEVKVTYLSEPAIMNELSPGIVIGTPDRMQEALCGASTTWKPHRAVLVETDVILSTHKVHVEAICSILWSRDVILGIHSLNPSPDVEDIVTRFCKGETARIPRPGITLSSVKHFYAAVKSASDKLAKLGEVWKLFRIRSDTVTVYCNSVSQVELVASGMESAGFEVAATHTGMPQHCIEETNRAFCQRGLLLITNIIYSGRQHVINFDMPESADRYLARAGVHRILWTRKVVSICSELEVCLLHEFERSLGFEADLLVARDHRLNGKKPPQRKR
The following text describes a protein:
Function:
In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking. The MON1-CCZ1 complex is recruited to membranes enriched in charged lipids, particularly phosphatidylinositol 3-phosphate (PtdIns3P), by GTP-associated small GTPase RAB5 homologs (YPT10, YPT52, YPT53 and VPS21). The MON1-CCZ1 complex recruits GDP-associated small GTPase YPT7 to membranes and acts as a guanine nucleotide-exchange factor (GEF), promoting nucleotide exchange on YPT7 and triggering endosomal maturation by recruiting downstream effectors such as components of the HOPS tethering complex.
Miscellaneous:
MISCELLANEOUS: Present with 2870 molecules/cell in log phase SD medium.
Subcellular Localization:
Endosome, multivesicular body membrane; Peripheral membrane protein. Prevacuolar compartment membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Vesicle. Note=The association of the MON1-CCZ1 complex with the vacuole is regulated by the C-Vps/HOPS complex. Colocalizes with the small GTPase RAB5 homolog YPT10 to vesicular structures near the vacuole.
Sequence:
MRLHYITVFDPSRSTNENDTFKQLLLFHYFGTTDSIPSLNEKLSIIGVIQGIWSLTSSCVNKDGEDLEKIIELNNDIIFCIKVESRFFISLAISNISDDQSAIPLQYLSAYLWLSYRFFKLLNGSFSGFNKDFRKLTDLLNEFVIPFWNDIYLNLETVTNRSFTVMWPGFYKRANFQHSSYNPGEKNNVEESWDAIILQNILLDKKSYLGLKDILVYHLPKRTKAANRESMGTKTYGLVRNFTSDLNTLPDISNWLYHLHCTYGEISSHILTGNVHFKEELQVEEEQERSRDTNGRDEEESQEQQRREHQETTQNNTSELSLSERVIHNVTLPISFAYDAIHEVSTTTGVSGSLSMIMDYVPKPHWPFISSSNKSADKNNYSNSNDNANSNAPLMAQSEAVGGTIGNSRFGFLISPLNSDLLPSSYQALKLNLNFENSKDKEDFYNCLFWYFDDFLIVIVCDPDFNKICERDYLKDLSFQLCQSMECLNNEILNSQNCDNVESFAYVIRDNVTKEIDSSVPFGSPKFTSDESISTLQLAINGIDQFINDNSNSLSLANWNPITIMGGSNAISKKNTTEGFGNGVNDKTQKFKRKYLNFLNLMSAEKLWDLQVDVLQFLTSLQNSKRDPDYFQEERLLKLNNGVLCYIKENNSNLIIIIKNWFQNNGTSKAAKQRNRFSSDSSKGSSLFQSLGRDVTDWWESREI