lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MNPPADETATGTSTPTSSSTPRRPGKRTAEEMALDLINNRPKVKRIVKLVSVFYEGKMLELDLNETTVPRGLIQWLRHLCSLIDEVTEGGFPKEWKVDDDPKNVLGPYTHDELVELVDMYNLVAKPFAGAWAGSYNTGNLGDWGNPHCTSEIAGSIVQLAIEMGIPKVEDLNNCYRAWSSENHILELISMTPMRLSMPPMRHVKKSSIMLFQVYGETNLNQMASILDEVGVTNKDVFIDLGCGIGQLVFFTAAYAQCKKSYGIELNPFPYQLGANVQSIFTKLMKNFGKRFGKNEILEGDLMNVVFRAKISEATVIFINNLLFDAEFMWRLKTEILQYLDEGVKIITTKPLGDPKKINVTDRRIGDLSAISETVYLKSLQGGVSWTDKPCRFYLTTINRMKLMNYFKQKRVMETEMSSKKKKPTKRNRSNDSATSSLDESTLSIPPTTDEPIQKRHAGRPKLPKAIPDVLDADTPSKSRGRPKQISESSKSSSRRRSSDDEDYKPPSSSIRRKPARRSSVLQPKQEPLDYTEMPLLVKEEILDDVKNEDVSDVMERMLEQVVKMV
The following text describes a protein:
Function:
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular Localization:
Cytoplasm. Sarcoplasmic reticulum.
Sequence:
MGVEIETISPGDGRTFPKKGQICVVHYTGMLQNGKKFDSSRDRNKPFKFRIGKQEVIKGFEEGTAQMSLGQRAKLTCTPDVAYGATGHPGVIPPNATLIFDVELLSLE
The following text describes a protein:
Function:
Plays a role in translation initiation. Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after formation of the 80S initiation complex. Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes. In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MAESKRSVDRLRAPVVCVLGHVDTGKTKILDKLRRTNVQDGEAGGITQQIGATNVPHEALMQQTKMCKDLQVKIPGLLIIDTPGHESFSNLRTRGSSLCDIAILVVDIMHGLEPQTIESINILKQRKTPFVVALNKIDRLFGWITNPHSDVTNLLKKQKQNTKLEFDERTSHVIVQFAEQGLNARLFYENKNPREYISLVPTSAMTGDGIGNLITLICELTQTLLVKRLTFTEELQATVMEVKAIPGHGTTIDVILVNGRLKTGSTIIVAGQDGPIVTQIRSLLMPQPMHELRVKSQFESHKEVLAAQGCKIAAKDLEKALAGLPLYVAEQSDEEDIFKEELSQMLKDVLSDVKVSDKGVYVQASTLGSLEALLTFLKTSEIPYAGINIGPVHKRDIMKASVMLEHDPQYACVLAFDVKIEKEAQEMADSMAIRIFSADIIYHLFDKFMAYRDEFKKQKREEFKHIAVFPCKLRILPEHIFNTRDPIVVGVTVEAGFVKEGTILCVPSKEFLDVGRVSSIEINHKVIEKATKGQEVCLKIDSIPGEAPKLYGRHFDNTDLLVSKISRQSIDVVKSWFREEMSKSDWQLIMELKKTFEIL
The following text describes a protein:
Function:
Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM.
Subcellular Localization:
Cell membrane. Cell projection, ruffle. Cytoplasm, cell cortex. Cytoplasmic vesicle membrane.
Sequence:
MPGKLKVKIVAGRHLPVMDRASDLTDAFVEVKFGNTTFKTDVYLKSLNPQWNSEWFKFEVDDEDLQDEPLQITVLDHDTYSANDAIGKVYIDIDPLLYSEAATVISGWFPIYDTIHGIRGEINVVVKVDLFNDLNRFRQSSCGVKFFCTTSIPKCYRAVVIHGFVEELVVNEDPEYQWIDRIRTPRASNEARQRLISLMSGELQRKIGLKVLEMRGNAVVGYLQCFDLEGESGLVVRAIGTACTLDKLSSPAAFLPACNSPSKEMKEIPFNEDPNPNTHSSGPSTPLKNQTYSFSPSKSYSRQSSSSDTDLSLTPKTGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFLTLTAFPPGLLVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLSPRFLQEGTVEGCLEQRRQKVPDVLFTTIDLPTDAVVVGKGCLIQARLCRLKKKAQAEANATAISNLLPFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGSYEQHISHMQKKINDTIAKNKELYEINPPEVCEEMIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDVPPPSGFYSCNTEIMPGINNWTSEIQMFTSVRVVRLSSLNLTNQALNKNFNGLCENLLKSLYFKLRSMTPCCLCHVNFTVSLPEDELIQVTVTAVAISFDKHQALQTTKTLVEKSLQRASTDNEDGLQFPLELCSDSLPSHPFPAAKEHLESASSNSGIPAAQRATSVDYSSFADRCSSWIELIKLKAQTIRRGSIKTTVTVEKASAMGDANSRSRSAPPCASPTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFAMVRAHVAALGGNAVVSYIMKQCVFMENPSKNQASGPLGRVRRVRASELCLLSPQAQCLINVSGDAVVFVRDSDLEVTSQQPAATCQPSCTGEVTT
The following text describes a protein:
Function:
Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (By similarity). Has a role as transactivator of the Myc promoter. Binds single-stranded RNA in a sequence-specific manner (By similarity). Binds G-rich elements in target mRNA coding sequences (By similarity). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Endoplasmic reticulum.
Sequence:
MSSNECFKCGRSGHWARECPTGGGRGRGMRSRGRGGFTSDRGFQFVSSSLPDICYRCGESGHLAKDCDLQEDEACYNCGRGGHIAKDCKEPKREREQCCYNCGKPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYRCGESGHLARECTIEATA
The following text describes a protein:
Function:
Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8.
Subcellular Localization:
Cytoplasm.
Sequence:
MALVPYEETTEFGLQKFHKPLKTFSFANHTIQIRQDWRHLGVAAVVWDAAIVLSTYLEMGAVELRGRSAVELGAGTGLVGIVAALLALKSSMKPLLVHCLLFFSGAHVTITDRKVALEFLKSNVQANLPPHIQPKTVVKELTWGQNLGSFSPGEFDLILGADIIYLEETFTDLLQTLEHLCSNHSVILLACRIRYERDNNFLAMLERQFTVRKVHYDPEKDVHIYEAQKRNQKEDL
The following text describes a protein:
Function:
Putative Notch ligand involved in the mediation of Notch signaling.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MGIGDLRSWTSVVVVILTLISMVSSSGFFELQILEISNTNSHLLSGYCCGLPPEKRQTQTTGCPACATAFSLCLKEYQGTTSSVQQQQQQLKQPAVAVEPQPSGLYGCAFGNASTPVLGGSSFVLTDPEVGGITLPFTFRWTKSFTLILQALDMYNESYSISERLIDETSFSGVILPSHDWNTLDHIGKSARITYRVRVQCADNYYNTTCTTFCRPRNDQFGHYTCGKQGNKVCMPGWQGANCEKAICKPGCDQIHGKCDQPGECECRPGWRGPLCNECMVYPGCRHGYCNGSAWQCICDTNWGGILCDQDLNYCGTHEPCMHGGTCENTAPDQYRCTCAEGLSGTRCEIVEHPCAPQPCKNGGTCTLTGNDKSAAVASSTVASIVVRGMRGMSSMGKPFGRSAAGAGGSSSAGSGSGTLDSKDQAKSGSSSSSAGLPAPSAGGPQPMKDFVCTCAPGWTGPTCEINIDECADAPCRNGGTCIDLIGKFRCECPPQWTGDTCQNDVDECESNVASGLGPCINAESCRNLPGSFQCTCLEGWGGPTCAKNLDDCVGKCKNGATCIDLVNDYHCACAVGYTGRDCSTDINECANFPCRNGGECVDFIGNFKCICPLGFSGTLCEEAKDHCVSSPCIEGQCLNTPGGYYCHCPPGRAGRHCEFPRVPCEKGGPCANEAGCTMPTSNDTAISGGPIVVPIPCSGRGKCESGPMGTSCVCQSGFTGPFCQHNVNECTSNPCANNGICIDGEGDYSCECQPGWTGKTCTERAIQCLPGQCLNGGSCIPSQFGGAPHCRCTLGWGGPFCSEPLDQCQGQPCHNGGTCESGPGWFRCLCAKGFSGPDCRINVNECSPQPCLGGATCKDGIGGFTCICPVGRRGVRCEILLSDPSSVCSNTTTNSPYDPLVSSDSLSKPKVGGAAASQAPSDETNCNSCICVNGKPRCSNLWCGLNNCLNRNQSSGVGSGCESHQVCVPTSQESCLTPPCQPRGDCRTFEPSRRVAPPKIPAPTDCWPNQATLGTACARISILLELNRLVRGTSVDGLCHLLRLQLGEKLIKNPSFDVSVFIVLLCDLKAGTNDTIEVTLSTPTDPVGGASSLTEAVRLLAEILSRQQGVQNDSFQTDLVEAAPLTSILEVKVETALVNEGSTGSNYLIAVGFGIAIVALCLGAVVALLWRQKVHSHSGSGTNLSPHLDLSRGMDEEKSNNLQNEENFRRYANPLKASSSSLRGAMELSLNPAPEINQIAGPSSVHHRSQQLYPPCTPDGAEFEKDPDKQKAANRNSHILLHKTQNADIMTKNIVGAIDSQHKDFGKRSINDHTASSAAANVSGVAASGTQSVGATSGTVAAHPVPDAPAAGSTLAPESDVLTVHV
The following text describes a protein:
Function:
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Sequence:
MALAQTEEIARRLTAAVPGLDVEIVKFDTTGDLDQTSKLLPHGGKGGAFVAQIRAAVLSGELQAAMHSLKDMPGNEDTPGLVIGATLSRDPPSDALVLRDGVTLEALRQSRGKGFKIGTNAVRRAAYARRLFPDVEVIHFRGAADTRVRKLDNGEKQRLPDGGAVGPADALIMARSGLDRVGLASRIAYEFTPAEMLPAAGQGIVAVECAAQDWQTRKILSSIDDPAAHACADAEREVLWVLNGHCNSPVAGFSTIAGDQMSLTASVLDLSGNTIIEASRTGSANRPRELGRAVGLELLGKGAAEIIERSRPR
The following text describes a protein:
Function:
Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. In response to DNA damage, deubiquitinates monoubiquitinated target proteins such as histone H2A and H2AX and thereby counteracts RNF168- and RNF8-mediated ubiquitination. In turn, participates in the recruitment of DNA damage repair factors to DNA break sites. Required for proper progression through S phase and subsequent mitotic entry. Acts as a positive regulator of TP53 by deubiquitinating and stabilizing it to promote normal cell proliferation and transformation. Participates in establishing tolerance innate immune memory through non-transcriptional feedback. Mechanistically, negatively regulates TLR-induced NF-kappa-B signaling by targeting and removing the 'Lys-63'-linked polyubiquitin chains on MYD88. Negatively regulates the activation of type I interferon signaling by mediating 'Lys-63'-linked polyubiquitin chains on RIGI and IFIH1. Also deubiquinates ASC/PYCARD, the central adapter mediating the assembly and activation of most inflammasomes, and thereby promotes inflammasome activation.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes preferentially with monoubiquitinated H2A to chromatin. Upon NF-kappa-B signaling activation, exits the nucleus.
Domain:
Both protease activity and an intact zinc finger are required for H2A monodeubiquitination.
Sequence:
MECPHLSSSVCIAPDSAKFPNGSPSSWCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQVPLTNHKKSEKQDKVQHTVCMDCSSYSTYCYRCDDFVVNDTKLGLVQKVREHLQNLENSAFTADRHKKRKLLENSTLNSKLLKVNGSTTAICATGLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLSASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRNKVDTYVEFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATHEGRWFHFNDSTVTLTDEETVVKAKAYILFYVEHQAKAGSDKL
The following text describes a protein:
Function:
Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity (By similarity). Axonemal dynein assembly factor required for ciliary motility.
Subcellular Localization:
Nucleus. Cytoplasm. Dynein axonemal particle. Cell projection, neuron projection.
Sequence:
MPVRVSEFSWQQTPATIFLSLPLRGVCVRDADVFCGESYLKVNFPPFLFELFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWDSLSVPGVDKEMMQRIREKSILQAQEKAKEATEAKAVAKREDQRYALGEMMKIEEEERKKIEDMKENERKKATSELEAWKECQKKADGQKRVQRKEKPLEGKQAEETKALKPRGLPRKAPPTRLPTRGRNWENIFPEKLKEDRVPAPRSAGSIQISFTPRVFPTALRESQVAEEEEWLHKQAEARRAMSTDLPEFFDLKEEERNPDWLKDKGNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALELLTPPVADNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPANTVVQNDAEKIRNIIQGTALKSRD
The following text describes a protein:
Function:
Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAEAEARPAEPAGWAKALMSVCSLMFGVSAWVSINGLWVQMPLLVPRLPEGWNLGSILVIVIQVANLGPLAYTLARKRRVGVVQVKAAVHATLFVGLTAGVLLVFLWQETVGGHSVAFIALAFFLSMVDCTSSVLYMPFMARYPQQFLFWYMVGEGLSGLVPAGLALAQGVDNKADNETTNATHGNATHAGGTVGPRFSIEVFLSLLCVIVAISWAAFSVLAHLPALKKEPSLKYGSNDNRGYVPEDGTDHVVPQVLEQPNGLERAGPSNDPGKGDDLMKRWQWNLALAMQSTIAALSNGVLLAVQTYSSLPYGQLPYHLATNLATIANPLSCAVAGLLPVRSLWALVLFTLGGLVCAGYILFLAVESPEPILVGTVTGAALMVLAWVAFVSLMTFVKSRLAAGMMSHGGARSLLWYGVATQGGSFVGALTMFFVTNYTHVFKSA
The following text describes a protein:
Function:
Probable transcription factor; Transcriptional repressor involved in organogenesis. Plays an essential role in ureteric bud invasion during kidney development.
Subcellular Localization:
Nucleus.
Sequence:
MSRRKQAKPQQLRSDEDPTLLELLPEHVSGEGVDDSDSGNESRSGSEETHVCEKCCAEFFKWSDFCEHLKTCTKNPLVLIISDNEVTSDPAQDYLPEPSPVPSCVSDPANSEDAVEVSHMPTEGDEGAEMMLESGAVLEKEDEPMEVELSPEKPIDPDDPVTLAEPDISLPPLEDHKQSSGAGYSIPSTNVTLETLHGTRVAVAQFSQGARGALASEVSTMAIPMILDQLMALQQQQLRQLKLIEQIRSQVALINNQAPTQTAVSHKVDHSINAALQVPSSSSIPAMPGQLHLRGFITPPINQLHMNNSLNVQASVAVSSALDVACTSVPPAGGQLASSGMKSNIAINSLYPTTSNGVSPQMPPCSVSISSSSCTSSSTGTGGEINCGISLPRNTPSPLTLTHGRLLTSPSSLPLVPHSSSNSVIFPNPLASIAATTNALDPLSALMKHRKAKPPNVSVFDTKPSSEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEYLDNVPTSSGIPYGMSLPPEKPVTTWLDSKPILPTIPTSVALQLPPTIPSIIESYGDSTSFSPLNRSPQRPSPPSSECTSLSPNHLITETSIAQISSSPQPNLASNTPPVLKPEALHLPPNSTTRPGETSISTTSISQVISTTIVTTTCSTRTQLTDPVNSSSAVSHPSLQISSNQFKPKFPFGGLLDSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQSALKMHYRIHTGERPFKCKICGRAFTTKGNLKTHFGVHRSKPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPLPDTFQDTDADLSFDEKSLDAMSNYDDELIDEMDQALEDETGLKDENMDLHKQLHLYSEMSPSTSPPTSLISSIGAFENEMKLSDPAVNITHSFSVKPTENGSGVDGVNGDMLKNDLSSTLVDLENHSVGSPAQSESSGSMLALSPTYSQSESHRSKSPQANSSSKDEALTSTSAHAMVKSEQLDIHSPGSENTGALDLTATQPTRSFVKDENPFSLLFLGRDRGLSTPSNISSESSTVKFENGHSKPPALCEGPHLPVGPQVPTATAQTTISSNITPMLAPPPPRRTPKQHNCHSCGKNFSSASALQIHERTHTGEKPFGCSICGRAFTTKGNLKVHMGTHMWNNAPARRGRRLSVENPMALLGGDAIKFSEMFQKDLAARAINVDPGFWNQYAVAITSGLAMKNNEISVIQNGGIPSIPISLSGGGIPAVGGMSGGIERSRTGSSPPVTGLEKTNLEMGTGHPFSRFREEDKEVGIN
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MAAAQPPRNATRVIEVLRNFLAGREIKPNLRYQDFIVKRSGPPPKLPSGPAHRLNKNYYYTRDLRREARPPVEISKQALLPASSEIKRAETESVKTVVPGQPVNWSENPY
The following text describes a protein:
Function:
Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
XSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKESSRNASLAEAGIGAIPSQLLAIEPSLRRSGVPIGEVGVSQRQEARSFSSANTHWFLEDLLGPSCRDTMIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLVAEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMILQQF
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MNRLTTDQKQKCVDFMSITQSNEIKAIQYLRDAGWNPENAIDRYYSNPANITEPRLDKKAIEALFKKYKDDEDSISENLVNLIKDVNISEEFMEFAFLWKFKAKQMDSISKNEFIDAMEKTIKCDSLKSLGNYFVQVKQQLLSPEPNNPHFKEYYQYIYDLGKATNQKNVSLQMCIELWTIVLKPKFADIQIWFDFLNSNHKLAISKDTWNLFLDFIRIANDDISKYDSDGAWPVLIDEFVDYYRTHKK
The following text describes a protein:
Function:
Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAGIKALISLSFGGAIGLMFLMLGCALPIYNQYWPLFVLFFYILSPIPYCIARRLVDDTDAMSNACKELAIFLTTGIVVSAFGLPIVFARAHLRPNVCIRDVSVLTRALPKLRSKARCTQEGVIQDPVGVVVWVTTLLPGNS
The following text describes a protein:
Function:
DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.
Sequence:
MTALTEYERKRLENIKKNQSLLSSLAIKSVGPAAKKGSKRPAPSSSTPSKKRGRPATGTDSPLPPKRHATRASVRLSGVGLDPVELQSRLEKEEQELASERQKREELKHSDRPLVAESLRTGPSSSLTSNLFSSLAHTIAVKPIKTMKEEEVNLEYSPGDDEDYDRLAGELKGLQLRSLNKVCPNRIYSMNFHPDPSKSLLFMGEKLGGVGIWDALGEQPAVKSEDVEDEDHVSTTSTNTADVSSKPSVSPAKPVKQEEEDDDEEDRPEFVEGVSYFIQAHARYSAVSAIQAHPSNPHLVCTSSYDRTIRELNFESQQSTEVIDGQALNPDEDTLFSAFEFANQGREIWASDNAGGLVHRDLRQPKTTARRWTVSKKKVGCLSLCPNSADRLAVTAGLNREMRLWDLRALSGLSPSSGLAEVEKDSCLATYAHGLACSSAYFNPAGDKILSTSYDDLVRIWDFEPSARDSWLDSHPSDLDLPPSFQARHDNQTGRWVSVMKARWCPNPRFPCHFTVGNMAQKLDIYNPKGELLTQLSHHALTTVPAVTAQHPSSSNLQVAGATAGGKVYLWT
The following text describes a protein:
Function:
Required for biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAKRKRRSRAAEEDVEPAEKEEVLPPISRKSDEPPQKKTKWINKQRVMIFASRGITFRDRHLMLNLRTMLPHSKPESKMEKKDPLVVINEAFNENPYTKLLKELLCQVFGTPRHHPKSQPFVDHVFTFSLLDHRIWFRNYQIVEEEGSLVEIGPRFVLNPIKVFEGSFGGPVIYSNPHYITPSAYRRTLKQAAASKYKGRKEAKANLKHRIAEGPAPSNPIDEIFETIPPEKAKGKDKLLFQRKKQ
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MSDVTRHGSTFVWGYGSDNGPSKWGQYYPICLGKRQSPINIDSLRTTFNPKLEHIQASHYISPQPNIKTTLTNIGKSIFIQPAIDYSPVLVDPLNSGVFYRAHHLHFHWGASDNYGSENAIDNKYYPIEIHIVHYNIKYQNVLQAIPKPDGLAVIGIFAKIGEGSAGFSWLLQYMQKLQYKDETVTANGFSYSSFLPKDMSKYFTFPGSLTTPLCEESVRWIVMEEPITISSQQSSFNLILHV
The following text describes a protein:
Function:
Involved in lignin biosynthesis. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH-dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.
Sequence:
MSRHFRTHTTSRLTFPSSSGGLAITRLPFSSTSSKLLLQQLSSTSPAAAATAVTITTSSPARNLQRARASAAEQGMEEHGKAAVGWAARDDSGVLSPYNFSRRAQKDDDVTIKVLYCGICHTDLHVVKNDWGNAMYPVVPGHEIVGVVTGVGAGVTKFKAGDTVGVGFFVGSCRTCDSCGKGYENYCPTMVITSNGKDYGGAATQGGFSDAIVVNEHYVLRVPAGLPLDGAAPLLCAGVTVYSPMVIHGLNAPGKHVGVVGLGGLGHVAVKFAKAFGMRVTVISTSPGKRREALEHLGADEFLVSRDAGQMAAAAGTMDGILNTVSAWHPVAPLFALMKPMAQMVFVGAPTRPLELPAYAIVPGGKGITGNCVGGIRDCQAMLDFAGEHGITAEVEVIKMDYVNTAMERLEKNDVRYRFVIDVAGSSLGGSGDDKI
The following text describes a protein:
Function:
Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.
Subcellular Localization:
Cell projection, cilium. Cytoplasm. Nucleus.
Sequence:
MREQRSFSSASQPHLEHAYTPVSGKPLPPKGLAVARATGIQYGGWILTLPSQGPLRRSSSRKPPLERRRPLPQSPLFFSARGDQGLTASSAFRMKNYKAIGKIGEGTFSEVLKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQALRRLNPHPNILTLHEVVFDRKSGSLALICELMDMNIYELIRGRRHPLSEKKIMHYMYQLCKSLDHMHRNGIFHRDVKPENILVKQDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPCQKTLTKFKQSRAMSFDFPFKKGSGIPLLTTNLTPQCLSLLHAMVAYDPDERIAAHQALQHPYFQVQRAAETQTLAKHRRAFYPKYSMVPESSSHNWSFSKEGRKQQPLRQEEGRARRQGPTSLTELPKLRLSGMTKLSSCSSPALRSVLGTGANGRVPVLRPLKCAVVNKKTDTQKDIKPHLKHCHLPTINRKGGEY
The following text describes a protein:
Function:
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Sequence:
MSKVIHVTSNEELDKYLQHQRVVVDFSAEWCGPCRAIAPVFDKLSNEFTTFTFVHVDIDKVNTHPIVKEIRSVPTFYFYVNGAKVSEFSGANEATLRSTLEANI
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MMKVLGFLVLLALSSALTCEAAIFKPISHSHRSAALELFTPADGSFKSFEEAYEALRTFEVLGIKKQPDQRADTCASVVDTLSSPSSALKDLFQALRVNGLLNCELNKKAFAGIVPRLKDAVKIASSLLDSYYSVGSLVLIKGLSSDVDVHLESADSVFRAIKALGQSDGRWRYSSNNPESSTYAAGIAFESLAGVISLASSEIDQSLISMVKNDISKLLGGLEKYDDGAYYFDEKLVDAQGHQGPLAASSAVVCGITSFATVSAENLNLPGDKILGLARFFLGIGVPGNAKDLYYQVEALASLENNRVSMPLILSLPTNVLSLTRKDPLKVNVNTVLGAAAPSLTVKLKQIFSSGSKDSSVIDQDLKFDHKNAVHYLDALPKDIDVGSYVFTFEVVLHDSEHRMIYATGGRTKVPIHITGVIKVNNAEISALDSDLGNVETRKKLDLAGENSVCLSANHLQKLRLSFQLTSPLGHALKPHQAFLKLTHESKLEHIFVVHNSGKQFEIILDFLGLVEKFFYLSGRYDIELTVGDAVMENSFLQPLGSVELDLPEPPEKAALPPPLVVDPSSRFGPKEEIAHIFRAPEKRPPRNLSYAFLALVLLPFVGFLVGLLRLGVNLKNFPTSAPATFAILFHLAIAAVLSLYFLFWLKLNLFITLKALGFLGIFLLFVGHRTLSHLASTSAKLKSA
The following text describes a protein:
Function:
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.
Sequence:
MTDAGSWCLIESDPGVFTEMLRGFGVDGLQVEELYSLDDDKAMTRPTYGLIFLFKWRQGDETTGIPSDKQNIFFAHQTIQNACATQALINLLMNVEDTDVKLGNILNQYKEFAIDLDPNTRGHCLSNSEEIRTVHNSFSRQTLFELDIKGGESEDNYHFVTYVPIGNKVYELDGLRELPLEVAEFQKEQDWIEAIKPVIQQRMQKYSEGEITFNLMALVPNRKQKLQEMMENLIQANENNELEEQIADLNKAIADEDYKMEMYRKENNRRRHNYTPFVIELMKILAKEGKLVGLVDNAYQAAKEKSKLNTDITKLELKRKQ
The following text describes a protein:
Function:
Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates cold or dehydration-inducible transcription. CBF/DREB1 factors play a key role in freezing tolerance and cold acclimation.
Subcellular Localization:
Nucleus.
Sequence:
MNNDDIILAEMRPKKRAGRRVFKETRHPVYRGIRRRNGDKWVCEVREPTHQRRIWLGTYPTADMAARAHDVAVLALRGRSACLNFADSAWRLPVPESNDPDVIRRVAAEAAEMFRPVDLESGITVLPCAGDDVDLGFGSGSGSGSGSEERNSSSYGFGDYEEVSTTMMRLAEGPLMSPPRSYMEDMTPTNVYTEEEMCYEDMSLWSYRY
The following text describes a protein:
Function:
Represses translation by preventing reactivation of elongation factor eEF1A (By similarity). May also inhibit nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. Has additionally been proposed to act as a redox sensor involved in cellular oxidative stress surveillance (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MAETEALSKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEEAYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRGKAGAEGFVRVDRDYVLKSAELAKAGGCKHFNLLSSKGADKSSKFLYLQVKGEVEAKVEELKFDRYSVFRPGVLLCDRQESRPGEWLVRKFFGSLPESWASGHSVPVVTVVRAMLNNVVRPRDKQMELLENKAIHDLGKAHGSLKP
The following text describes a protein:
Function:
TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
Subcellular Localization:
Nucleus.
Domain:
The C-terminus is important for mediating interaction with e(y)2.
Sequence:
MSAEKSDKAKISAQIKHVPKDAQVIMSILKELNVQEYEPRVVNQLLEFTFRYVTCILDDAKVYANHARKKTIDLDDVRLATEVTLDKSFTGPLERHVLAKVADVRNSMPLPPIKPHCGLRLPPDRYCLTGVNYKLRATNQPKKMTKSAVEGRPLKTVVKPVSSANGPKRPHSVVAKQQVVTIPKPVIKFTTTTTTKTVGSSGGSGGGGGQEVKSESTGAGGDLKMEVDSDAAAVGSIAGASGSGAGSASGGGGGGGSSGVGVAVKREREEEEFEFVTN