lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (By similarity). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells (By similarity). Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity. Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
Subcellular Localization:
Nucleus. Endoplasmic reticulum. Secreted. Note=Translocates from the endoplasmic reticulum to the nucleus during apoptosis. Contradictory reports exist about the subcellular localization under normal physiological conditions. Under conditions of cell death, may diffuse and/or be actively transported to the nucleus.
Sequence:
MSRELAPLLLLLLSIHSALAMRICSFNVRSFGESKQEDKNAMDVIVKVIKRCDIILVMEIKDSNNRICPILMEKLNRNSRRGITYNYVISSRLGRNTYKEQYAFLYKEKLVSVKRSYHYHDYQDGDADVFSREPFVVWFQSPHTAVKDFVIIPLHTTPETSVKEIDELVEVYTDVKHRWKAENFIFMGDFNAGCSYVPKKAWKNIRLRTDPRFVWLIGDQEDTTVKKSTNCAYDRIVLRGQEIVSSVVPKSNSVFDFQKAYKLTEEEALDVSDHFPVEFKLQSSRAFTNSKKSVTLRKKTKSKRS
The following text describes a protein:
Function:
Plays a role in translation initiation. Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after formation of the 80S initiation complex. Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes. In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MVKAKKGKKEILTKVEGGSSVDEISDVDSDQLSLNNKQNHALKGNQAGDDDVKAVTKGVKKLNVKGKGKAGKNDDSDEEEVVPAKGKASKKSAFELLMDDDEQDEPAAQESQSEKEEKVVVSKPQKNEKKGKKAKRKGKDDDDEDLDKVLAELQAEYAGEAAPAATTVVSPEELADEFSKKKKNKKQAKQAAVAENAGEDEASDDEEGGSTVKSAAQKKKEKKERQKREAALAKQKAATEPKPKPVEKPAPEPEPVATEEVQPAAEEEEEKSSKNKKKGKKDKKAEPEEEKKDAKKKGMSASMVAAMQEQLRKRKEEEERLEREEAERIRLEDEREEARLEAVRLEAERKEKKKQREAERKARLKAEGKLLTKKQKEDRARAQALLESLKAQGLEIPDPNDKRPTRPGTRIRPNKKKGPKEEAAEEEAKAAEAEAQSAAAAAAAAAAEKAEEERVKESWDATDSEAEPEPEEETSQATNNGKTEAAEEENEDTDDDEDDDDDEDDSDDSDGDSDDSREVSVLANDPESRRLRAEARILKRQAEAEKKRSTDELRAGVVCVLGHVDTGKTKILDKLRRTHVQDSEAGGITQQIGATNVPIEAIKEQTKYVKAAAGFEHRLPGLLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESIQLLKKKKCPFIVALNKIDRLYDWKQLARRDVRDVLKEQQSNTQLEFQQRTKDVILQFAEQGLNAALFYENTDPKTYISLVPTSAISGEGMGNLLFMIADFCQNMLAKRLMYSEELQATVLEVKALPGLGTTIDAILINGKLREGQTMVVAGTDGPIVTQIRSLLMPQPMKELRVKNAYVEYKEVKAAQGVKIAAKDLEKAIAGINLLIAHKPDEVEICTEEVARELKSALSHIKLAQTGVHVQASTLGSLEALLEFLRTSKIPYSAIRIGPVVKRDVMKASTMLEHEAQYATILAFDVKIEREAQEMADSLGVKIFQADIIYHLFDKFTAYREELKQKKREEFRSVAVFPCKLRILPQFVFNSRDPIVMGVMVENGIVKVGTPICVPSKEFVDIGIVTSIESNHKQIEFARKGQEICVKIDPIPGESPKMFGRHFEADDMLISKISRQSIDACKDYFRDDLIKADWALMVELKKLFEIL
The following text describes a protein:
Function:
Mediates the NAD(+) import into chloroplast. Favors the NAD(+)(in)/ADP or AMP(out) antiport exchange, but is also able to catalyze a low unidirectional transport (uniport) of NAD(+). Transports NAD(+), nicotinic acid adenine dinucleotide, nicotinamide mononucleotide, nicotinic acid mononucleotide, FAD, FMN, TTP, TDP, TMP, UTP, UDP, UMP, CTP, CDP, CMP, GTP, GDP, GMP, 3'-AMP, ATP, ADP, and AMP, has low transport activity with cAMP, pyrophosphate, NADH and alpha-NAD(+), and has no activity with NADP(+), NADPH, nicotinamide, nicotinic acid, adenosine, thiamine mono- or diphosphate, inorganic phosphate, CoA, folate, NaCl, malate, malonate, citrate, fumarate, aspartate, glutamate, S-adenosylmethionine, lysine, arginine, and ornithine.
Miscellaneous:
MISCELLANEOUS: Appears to be a chloroplast envelope-located membrane protein lacking an N-terminal-located transit peptide.
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MSANSHPPNSKNVLCNAAAGAAAGVVAATFVCPLDVIKTRFQVHGLPKLGDANIKGSLIVGSLEQIFKREGMRGLYRGLSPTVMALLSNWAIYFTMYDQLKSFLCSNDHKLSVGANVLAASGAGAATTIATNPLWVVKTRLQTQGMRVGIVPYKSTFSALRRIAYEEGIRGLYSGLVPALAGISHVAIQFPTYEMIKVYLAKKGDKSVDNLNARDVAVASSIAKIFASTLTYPHEVVRARLQEQGHHSEKRYSGVRDCIKKVFEKDGFPGFYRGCATNLLRTTPAAVITFTSFEMVHRFLVTHIPSEQSSIL
The following text describes a protein:
Function:
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Sequence:
MSCYIYQLPAWVLDDLCRNMDTLSEWDWMQFASYVITDLTQLRKIKSMERVQGVSITRELLWWWGMRQATVQQLVDLLRRLQLYRAAQIILNWKPVPEINCSFLDFPEAVKPGRPLEASVRTMEDEQEKGPSVRPADFPGPGHGQTHEPSFPGPAPARTNLLPPSADAPHSLKTDVPVSSNSKDFSTSIPKQETLLSLAGDSLFWSETDVVQATDNFNQNYKISEGNFADIYKGQKHGTLFVFKKLREAAYSGPGSIEKFFQAEVQICHRCCHPNILPLLGFCTGNQLYILIYPYMANGSLQDRLQDQDGSEPLLWPQRASICSGLLRAVEHLHGLGIIHGNVKSSNVLLDQNFIPKLAHPIAHLCSDNKRSKYTMMKTHLFQASAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLGEIPSSTTSLGCRKTGVEKVMAKEICRKYLEKRAGRLLEDCAETLALAACLCLRRRNACLAEVCGSVAAVEERLRGQETLLPSSGLSEGTSSSSNTPEETDDVDNSSLDASYSMRVAPGAGAAASFLPTEDGEGRLQVCGGMQADSSSVACAGPEPPQDETSWKIEINEAKRKLMENILYYKEGKLDSIELLGP
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MMSSDAIPCNRCGNQGGSPPFGSIPMSLHKVGSLNRSLAGSINSSRGDSGCSSLELEAVAAMHELSFAVQSICVSEMLPRTGDLLFVNVTTTEGQPYCLELTLKGWRVTSLRSDCMIGDFTKLDMFIKYYDSLYSLLDDISPGYRQRFGERVAKKLMMLQNEDSCDIIAPSSSYCSPPFSMSPSDSTESLPIVTPVPSPVPEREERHRDTPFDRDRLFEFPIRRDFNHFTMFGACRMLRSRTVQQVRSVSTSGGSSKIGRVFAGTLVVLGTGSAAAVYLLDIPIGESIDSVLPKGWQLFHKAAPAIERKHVILPLEPRPLKPFPDSIPAVSKKDDDNNKTEKEKPKKESIPPTKKPIRPPTLEEREESIKSALISAEKRVKTATQAKALSMDAIDEHIKTLRNAIQGGLAGDWDSVRNANERVANCRSEDKAEENDARNYIDMLKGVLKELSPHLNGHPIIRSALSSAAKLEKELDEMAYSIKMVESEQIFSLEYADLVQSARGRFADELRAVLPSFDWDGESKMKKVQLNALLTHAHLRLDQLRRELIESKLREESRLENALKKEMAKREKVIEGEKKLSEDNEAELLRRLKIVEEEHATRLDQMVRAQRELSKIEKEQEIVEAVTIERQKHSHKLAVAQSKVEGIEEALKRRIVLDGENRRSKQTWLACHELMESIEYGTKGGKTMEKRKRPIGEQLKRLGEVSEGDNFVSAVISTVSEKVKKEGEFTREDLENRFEKVYTIARRVSFIPENGSTIWGYFTSWIRSTITFPFPIKENDRIDWLTTDNVLLLDTARSLVKKKKYLEASKLMELLKGEAKLIALSWSSDVRSLEESLFLIRLLTVHSALQSMAEGWFKFTGSSPYPTLTTNFDHSKFTYGNMQNRQFRMGWASLMIFLIFSRVNQVFQIEGKRDEGKERNILEWISRSNRISFVDRDDAAAKLSDGIILCEFVNNINSQALARNISHKSSRFAATENLENFQDGLIALGMNKSQLFPISDLIEKKDISSLVNTLDILKQM
The following text describes a protein:
Function:
Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene. The alpha subunit has a catalytic role in the holoenzyme.
Sequence:
MNYKNKILVSESGLTQKHLIHGDEELFQHELRTIXARNWLFLTHDSLIPSPGDYVTAKMGIDEVIVSRQSDGSIRAFLNVCRHRGKTLVNAEAGNAKGFVCSYHGWGFGSNGELQSVPFEKELYGESLNKKCLGLKEVARVESFHGFIYGCFDQEAPSLMDYLGDAAWYLEPIFKHSGGLELVGPPGKVVIKANWKAPAENFVGDAYHVGWTHASSLRTGESIFSSLAGNAVLPPEGAGLQMTSKYGSGMGVLWDGYSGVHSADLVPELMAFGGAKQERLNKEIGDVPARIYRSHLNCTVFPNNSVLTCSGVFKVWNPIDANTTEVWTYAIVEKDMPEDLKRRLADAVQRTFGPAGFWESDDNDNMETASQNGKKYQSRDSDLISNLGFGKDVYGDAVYPGVVGKSAIGETSYRGFYRAYQAHVSSSNWAEFEDASSTWHTELTKTTDR
The following text describes a protein:
Function:
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MAQAFVNSKIQPGKVVVFIKPTCPYCRKTQELLSQLPFKQGLLEFVDITAAGNISEIQDYLQQLTGARTVPRVFIGQECIGGCTDLVNMHERGELLTRLKQMGALQ
The following text describes a protein:
Function:
May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKGFLFLLLTISLLVMIQIQTGVLGNSTTPRMTTKKVKSATPALSSLGGGSVLLFLANTLIQLFYLS
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MYSRYVPPSKKKVTVGDQLSQAPLSPLKSSSPPPPPSPAPAIRPDASSSYARYIPPSKSNVKPDAQLNAPKLGLESPSPASKRKREDALEPGPEPVLKKAKKDKKEKSVKVHASATLDEPHADNASSEEAQEVTKKDKKQKKKKSSDDSTSSEETTENPEDIDDKRHKKVLEKREKSIKKAERRARKAAEEGRDAEDAQEPEEPVEIHNLVPLPQPEPIPELPPPSLESTLPSWLASPILVSPTTTAQFSEVGVEAEAATVLRSKGFNEAFAVQAAVLPLLLHGTRQKPGDVLVSAATGSGKTLSYVLPMTQDISRNIVTRLRGLIVMPTRELVSQAREVCEVCSSAFSAGSRKRVKIGTAVGNEAFKVEQANLMENTYKYDPARYHEQERRKNLRWESSDAGTDDEGEPLLDDEAISPLPDHIIEPVSKVDILICTPGRLVEHLKFTPGFTLEYVKWLVIDEADKLLDQSFQQWLNVVMSSLATGQNSFPNNRDRVRKIVLSATMTRDIGQLTSLKLYRPKLVVLAGSSAGDDGKSSHAHILPPGLVEFAVKVDDENLKPLYLMEILKGNDMIDDSKIKSDSDTDSDTDSDSDSDDSSSDSSSDKDSSEDSSSSDDSSISGSDSESKPDKVSPKSKPKFKTNPLPISHEPHGVLIFTKSNESAIRLGRLISLIHPSYTEIIGTLTSTTRSSERKASLASFSRGKLQILVASDLVSRGLDLPDLAHVINYDVPTSITNYVHRVGRTARAGRQGHAWTLVGNSEARWFFNEVAKSEEIRRRESAKVKRIVVDARKFGEYKKETYEEALEELGQEAMAIRSKK
The following text describes a protein:
Function:
Acts to suppress chlorophyll degradation under moisture stress.
Domain:
The BURP domain located at the C-terminus has not been identified in non-plant proteins.
Sequence:
MAIRLPLICLLGSFMVVAIAADLTPERYWSTALPNTPIPNSLHNLLTFDFTDEKSTNVQVGKGGVNVNTHKGKTGSGTAVNVGKGGVRVDTGKGKPGGGTHVSVGSGKGHGGGVAVHTGKPGKRTDVGVGKGGVTVHTRHKGRPIYVGVKPGANPFVYNYAAKETQLHDDPNAALFFLEKDLVRGKEMNVRFNAEDGYGGKTAFLPRGEAETVPFGSEKFSETLKRFSVEAGSEEAEMMKKTIEECEARKVSGEEKYCATSLESMVDFSVSKLGKYHVRAVSTEVAKKNAPMQKYKIAAAGVKKLSDDKSVVCHKQKYPFAVFYCHKAMMTTVYAVPLEGENGMRAKAVAVCHKNTSAWNPNHLAFKVLKVKPGTVPVCHFLPETHVVWFSY
The following text describes a protein:
Function:
Functions probably as a transcriptional factor that activates genes involved in secondary cell wall biosynthesis. Functions redudantly with C3H14 to regulate secondary cell wall formation. C3H14 and C3H15 have overlapping roles in the regulation of secondary cell wall formation and anther development. C3H14 may contribute more to secondary cell wall thickening while C3H15 could be more important in anther development. May regulate at both the transcriptional and post-transcriptional levels the expression of many genes involved in various biological processes, particularly those associated with cell wall metabolism and pollen development. Involved in the regulation of callose metabolism in male meiocytes, in integrity of newly formed microspores, and promotes male fertility. May be involved in the regulation of the callose synthesis genes CALS5 and CALS12, the potential degradation of callose walls-related genes A6 and MYB80, as well as other putative beta-1,3-glucanase genes. Negatively regulates cell elongation by inhibiting brassinosteroid (BR) signaling. Functions downstream of the BRI1 receptor as a negative regulator in the BR pathway.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing C3H15 exhibit small and slightly curled leaves, and retarded stem elongations due to cell elongation defect and ectopic secondary cell wall formation. Overexpression of C3H15 results in secondary cell wall thickening in fibers and vessels; MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes in cytoplasm in the absence of brassinosteroids (BRs). Upon BR perception, C3H15 accumulates in the nucleus.
Sequence:
MENKIAPFSYSGSSAGNSSSGGVVSSSLYSDQLYKSTRNIMQQRQDMVNREALCYTRLHEASLEAEALRLENTELRSMNLRLKNELNSLIRSSIQNRFDHRSPLRMLSNLSIGGNDADEVENQNRTVNRDDVNDKSPTSVMENEDLNRSSLPKSISVRSNGYSKASQGGGGAAAQSGKPRGTVTKPGTCGQVSTTQKVYVRGGGKKEDQEEEIEVEVYNQGMTKTELCNKWQETGTCPYGDHCQFAHGIKELRPVIRHPRYKTEVCRMVLAGDNCPYGHRCHFRHSLSEQEKLVAAGFKPKSSLKLIT
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase. When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
ADQPDILRASQKDEYYKKLFEDQIFEVLTTVIGPRVLMNKQSESKLLANTLYYLLTTMIGAQTLGEEYCNLRKIKDNTFSIPNIADRTQLYIFHLLGPYLIKKALPKLFLKYPKLYILKEMFPKLERLHLALFYFNGSYFEFSKRLSNIRYIFNRKIDQKRPKYDILGLLIIIQLLLSTFMYLKENSFFLKSNQNDTEEIEELNEKNLTNENNNQDSESDAKCTLCLEKRTHTTATICGHLFCWHCITEWCNNKEQCPVCRCPMGIRTCIPLYNY
The following text describes a protein:
Function:
Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule. Plays a role in cilia formation. Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors. Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MANKAKPSEALKVVARCRPMSRKEEAAGYEQILEMDVKLGQVTLRNPRASPGELPKTFTFDAVYDASSKQADLYDETVRPLIDSVLQGFNGTVLAYGQTGTGKTYTMQGTWAEPEQRGVIPSAFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQARAVGSTHMNEVSSRSHAIFVITVECSERGSDGQEHIRVGKLNLVDLAGSERQGKAGTNTSGGAATQPSGGGGGTGERPKEASKINLSLSALGNVISALVDGRSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLEKRGLLGKRRRSSRRKKSLAIEGYPEGSVTEAWVAEEEDDNNNNHRPPQPTPEVPLEKNMENYLQEQKERLEEEKAAIQDDHSLVNEEKQKLLEEKEKMIEDLRREQQATELLAIRYKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMLLRDEETMELRGTYTSLQQEVEVKTKKLKKLYAKLQAVKAEIQDQHDEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMNRLYLDCEEEQWKFQPLVPAGVNNSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENILFLELDVSPPAVFEVEFSHDQEQDPRALHMERLMRLDSFLERPATSKVRKSRSWCQSPQLLPSSTSHVPLASTSLRPSTMLAHE
The following text describes a protein:
Function:
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLRMTRMSTVLSIFILFLHTTFGESGCTSADGDGTFGDDEPDNFDIDCFSQLEFKDSYSSLTCNFTELPPHNTNYTLAVCTKEDSSYLCFNMEKQEDVYFLQFTDILSNKDICVEYEIKRRACRSLIVTDIVKPEVPFDINITYQKEANEYLIHYSTPHSRKKYLKDKLIHQIAYRQEESTWKTIKSPYLQVKLLGKNLEADALYEVKVRSQPNGDYFKGIWSEWSTSKSFRTTGEHSMESYSSMFVIILSIPGFILSVVMIVLILTFWESRIKPVVWPNLPDHKITLERLCKRPKNNFDISFNPESFGYVFIHEVDGIQAKAEQENFLQPPPTPETDIPPKFRSGSDLKRSPARIDKNSLNLSVSYGGIWPAEALHGLFGCSQSTAADVCSSGTYEVCHSSRVPLCDNGFHLPSAPPLDPPGQPGPQPQNGNVVPPNSELKSPSDEEAYVTMSSFYKNQ
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body.
Sequence:
METAEQPQEMHSDITTSPPTIAQRLKQELALSSIHRNEVESHWRQILRKEKFQELKDEIGPLAEYHERNVKRKIHVIESTQQEFDHLQELYRKTMVANILRMDELITIHDDQMILLERDFRERVSLLQKEFHCDVERIVQQYDSEKDSVHQSIQKVERNDHYRKELLRQEQHNELEEIKNRNLGEINSLRSQLKSKVEEVEEQFEQAHSDFAQSTNFAKAAYEQLKAKDSKMQKDIDRKTRHVDRLRSEIQRFQLIAKQEEVQNRERQQALLQRKTRAIKMFQMTKDEMANFRKYQQQRLIVLSRNANDRKEEMRQQYLLAERVKKIATACQKCETSREEFAHVLRDVIGNASVAKDDHVPSSFLQDDLMVEESIEVNPKKNTLLWNNTHHFWDKYNMAQIDVIALGKQVDRLKQKEQALRKKLKMYQDGITVNDDVLKDRNPLLVINGKMNIPQEGNVRIGRNGRKVMRRLTVVDGNHITNCFATQQLSR
The following text describes a protein:
Function:
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MKLLKPAWVTHDGKPIFSIDIHPDGSKFATGGQGDDSGRVVIWNVAPIVKEQAEEDDNVPKLLCQMDNHLACVNCVRWSNSGQYLASGGDDKLVMIWQLTRYAGSTIFGGGGKTNVEHWRCVSTLRGHSGDVLDLGWSPDDQYLASSSVDNTVRIWNMLNMPESIAVLKGHTGLVKGIAWDPIGKYVASQSDDKTVRIWKTADWKQETVVTEPFEECGGTTHVLRLNWSPDGQYLVSAHAMNGGGPTAQIIEREGWKTDKDFVGHRKAITCVSFNSNMLRKSALHKGTNYCCCAIGSRDRSLSIWLTSLKRPLVVIHELFLNSVLDLSWSRSGYQLMACSWDGSVAYIEFDDKELGQIVSVEEKENLFQRMYGKKSFSTGVDKKASIVIEDPDWIQPQLMEPTVPSIIEEEGGMHSSDSRASRSSQIVAKGPIDKQIETRTVDGRRRITPVFIPPPMEEDDAQSSHASNHSSAALVQPTFSSSTEAKSKIVVEKRDEVTKPGLSNTTSPPPPQANARKEMSNILLNRRLERNEPERRVVSVRTSGPSTASVSTTGVSIVRSPDSDKVAISPLSVQKTFSVPTSHGRSFEIENQSYFVGHKMAVHKLSCVVNGKVAWDVYMSSPMIGCAASLYCAAVTCSDATLHCFSVGDGSRMIPGIKLQGSAVHLRVQDHFVSVVTAHGQISVWDIIKRKSTLKTSILNLTDSDGSVTLTSCTIRDGGIPILSFSNSKTYTYSTDMDTWLLLSDALDPLRHGSDLQGISSSGAGPGANRSSVINSADSKITCSISYADVKMSSLVELNSPAEYRTWLLTKVKYMAQQGMEDRLRSLCEDLLGPVHRSSQRGKNWQPTILTMKKNELLIPVLQVMATNVKMQRLCTEFQQQLKMLTEF
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MNTTPIRHSGLQKAVLSLYRSFLRVSNKKEMDNPSSSISNYIKTQFRLKATTIQKRDINKIESLLVKGKRQLEQIQDPEFSGFAVFTPKSK
The following text describes a protein:
Function:
Expressed in gonadotrope cells, acts as an inhibin B coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MLGTVLLLALLPGITTLPSGPPAPPFPAAPGPWLRRPLFSLKLSDTEDVFPRRAGPLEVPADSRVFVQAALARPSPRWGLALHRCSVTPSSRPAPGPALALLREGCPADTSVAFPPPPPPSPGAARPARFSFRLRPVFNASVQFLHCQLSRCRRLRGVRRAPAPLTPPPPPPPSRCLPQDEACADTGSGSAEGLAADGPHLHTLTQPIVVTVPRPPPRPPKSVPGRAVRPEPPAPAPAALEPAPVVALVLAAFVLGAALAAGLGLVCAHSAPHAPGPPARASPSGPQPRRSQ
The following text describes a protein:
Function:
Probable transcriptional coactivator.
Sequence:
MDCYAEELVVPNYQESSSETYPSTGMWGGWSMSSPEAAEKCFDYDGFNGEGMMYSQMSMRTSEEEEESKRSKAFYGASSLHDFEGIEQMDDMFLSSILEDVPEDDGDVHRATSSNNSVGSSSMYGGGREVPMFHCHDMSFKEEAPFTISDLSEENMLDSNYGDELSSEEFVLQDLQRASQKLTDETRKCFRDTFYRLARSSQDKSDSVSPNSEELLMQTSRYDYGDGNRFSREEEIESETNSIDRAVANLTFNKMESNISNFPLSERVQ
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAHGSKFSMTPVCSTYMPWARSYHPRLSLTLATKTSGIQEIPEVTFPCFPSRHCCHFLVSWRCVALVSHRACGWRRGGKCGPHSGRDTGRAGVLARGGASSRSGRLAWGRLGLLAPVRQRCTGQTRPGDTLLTSFLDSEKQFLQLEAETHFQCACCSWDQLLSGITMTMEGRGTLDIIPRTAVYQKQEGSLTVKQEPGSQTWGQKNCPPVCEIFRLHFRQLCYHEMSGPQQALSRLRELCHWWLMPEVHTKEQILELLVLEQFLSILPRELQTWVQLHHPETGEEAVAVVEDFQRHLSESGEVSPPVQEQDVHLKKMVALRATEQSPTLTSGCCSAPDDLLNPPCDPGAHHFPSGHFDPAFPRVGNSRAQAVASVLRMVRPQETAVNKACMQEKWSVLCEAEVVRDEHGPAYLGKNRMGSSEYSPKQGISKGSHSLDTSSGGLFGVALVEPESGDICEDPLAQVEGCPSDEGSELESDFLEKNDEKNSTKDRIEDSKDVRERPESPSSPAEHQREAKRQNSYQCDECGKIFNRSSHLLGHRRIHTGERPSECNECGKTFLQTSQLIVHLRTHTQEKPYECQESGKTYCHSSRLIQHQRLHNGEKPYKGNECVKASIQSSQLIDHKGAHAAEKPNESEEAFIWSKSLQHQVLHTSKKPYECNECGKAFCSNRNLTDHQRIHTGEKPYECIECGKAFSRSKCLTRHQSLHTGEKPYKCSECGKAFSQNSQLIDHERIHTGEKPFECSECGKKFSLSKCLIRHQRLHTGEKPYKCSECGKSFNQNSHLIIHQRIHTGEKPYGCNECGKVFSYSSSLMVHQRTHTGEKPYKCKDCMKSFGDSSQLIVHQRVHTGEKPYECIECGKAFSQRSTFNHHQRTHNVEKPSSLLQTVS
The following text describes a protein:
Function:
Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MSIEAVWGTLQDGLNLLYRREHMSKKYYMMLYDAVYNICTTTTLANSNNNSPEFASEFLYKQLENYIRTYVIAIRDRISACSGDELLGKCTIEWDNFKFSTRICNCIFQYLNRNFVSKKVEDKNGEIVEIYKLALDIWKAEFFDNFKVKTIDAILELILLERCGSTINSTHISSVVECLTELDIYKVSFEPQFLDATKLFYKQEVLNSKETVIEYMITVENRLFQEEYRSRRYLGPSTNDLLIDSCESILISDRLKFLHSEFERLLEARKDEHLTRMYSLCRRVTHGLEDLRVYLEKRILKEGHETLQRLAKDSGLKTTPKEYITKLLEVHEIYFNLINKAFDRNALFMQSLDKASKDFIEANAVTMLAPEKHRSTRSADYLARYCDQLLKKNSKVQDETALDKALTVLKYISEKDVFQLYYQNWFSERIINNSSASDDAEEKFITNLTATEGLEYTRNLVKMVEDAKISKDLTTEFKDIKTEKSIDFNVILQTTGAWPSLDQIKIILPRELSTILKEFDTFYNASHNGRRLNWAYSQCRGEVNSKAFEKKYVFIVTASQLCTLYLFNEQDSFTIEQISKAIEMTAKSTSAIVGSLNPVIDPVLVVDKGNEKDGYPPDAVVSLNTKYANKKVRVDLTTAIKKATADRETDAVQNTVESDRKYEIKACIVRIMKTRKSLTHTLLINEIISQLKSRFTPNVQMIKICIEILIEQLYIRRSENEHNVYEYLA
The following text describes a protein:
Function:
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MTMTASDKYTYQRTVLCLARVLAGIQPTPWDKVHVHLATHSTSHSASPPGNRLFALTLSGGHKTDMRGRSGGGGKAVQTLFRYCPQENAAGVFCLDTRAQDAVIALGIYFLEGGCQHEGQIVPYLLRLAKRSHSVGGKVQLLLEHPAVRHSGQVSGFARGDHPESGGNAERAGQHSQVEQGQQLRTAAHHPVQGHGAAALRLGAIDGSLCQQRSTAAVPHFSARAAAHPEGRRPRRHRLEQQCQRHCGGSFSSSERLAATHHFRPIIPRSMSGSLAQAQNASYDDGRQRCAGGKPSKPSLHSYFSVPYDPRTHFFTRYGSSFNQFPNMRVCESPTKGGPRPLYRVPPFPIQHLQTIFAVSKKLLTKDTLEHLDEQASDIFSLHQIKGYCYKSFSETLNLVLVTLLRELLQHQVDLPTPFTKDVQEFVKRLFLNGQTELQNKQQDQERERREENGIAVVNKYKVNVMANAACVDLLVWAIRDETEADKLCGRLSQKLNLELSHKIVMDHMPLLMVCLEGLGKLAHKFPNIAGTSISYLRDFLVAPSPILGKLHDHAMQSLAQQKKEKELTPFKIAVQHSDSRTAVVIYGDNQKPPGSGTGRSGHAAFESLRDAAIENLSIALRAAHTLDQFCVPALVANVSNRLFTAEKSGSESQGECHKSNLVSLNIIVMLGHVAVALKDTSKTTQNILQFFIQRFCKVPSEQNALIVDQLGCMIISQCETHVFDEIMKMFSRVTVQSASLAYTSDPEHRKQFHHVSDAVVNALGNIAANIQGDAEMLELLGKLLELFVQIGLDGERSYDNTPGAQKASSRAGNLGMLIPVIAVLVRRLPPIKNPRQRLHKLFKDFWAYCVVMGFTNARLWPADWYQGVQQIAAKSPLLISQTAHKSDMRELNYTLAIKSDSVNELRSQILVLLEHSSDNVATAINKLSFAQCTYLLSVYWLEMLRVENADEPSLEPIMSYLCDTALQRDKTGIWQCVKCVADQVFEKFRNVLYAHDEIREKVLESQATLLLVYFNHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQLLAYSLSLDPNEETPTLRVVSTPYTLQLMDSLPARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTMSKRPSCVNSDTPRFVSVLCLRSKYAGEISGLLSVLSEKDKAGLADRLVSDVWEACAEKSDARHRGALWRATAYLIICSEISRKLLHAVASSQLELFTESAMETAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKPILIAPHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVLKSSKQNRQVSTVGCRFKLLQCGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLEDIMILLKFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEFLITWYNPNSLPDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVATKNNKEAAAHMLAVIRNSYQNFRTRTYDMIQYYQNQIPY