lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPMDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDPKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLASARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSATRKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLFVN
The following text describes a protein:
Function:
Necessary for formate dehydrogenase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRTILQPGQIEAAANIPPHLHQPSRDLFARRGERLLQLAEGHPMGDYLRLVAGLCRLQQALLDNPPALAPLDPERLRKSREHGMPPLAYDLLVREGAWLPWLDALLAGYPAPANAAVGAALEQLREAEEGQRKAWAIALLSGQFDLLPAALVPFLGAALQVAWSHWLLGLEEGAVVETESRTLCPACGSPPMAGMIRQGGKETGLRYLSCSLCACEWHYVRIKCSHCEESKHLAYLSLEHDGQPAEKAVLRAETCPSCQGYLKQFYLEFDRHADALADDLASLALDMRLAEDGYLRRSPNLLLAPGGE
The following text describes a protein:
Function:
Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate.
Sequence:
MSASIGNKILAAGTKIVAVGRNYAAHAIELGNAVPKEPMIFLKPTSSYVFQGGAIEIPPPLTSLHHEVELGVVIGKKGRDIFEDEAMDHVSGYALALDMTARDIQTVAKAKGHPWTVAKGYDTFTPISGFISKDEVPSTDNLELWCEVDGVMKQKGSTKDMIFSIPLLISYISRVMTLNEGDVILTGTPSGVGPVTAGQHVKAGITGLVEMSFPVETRVHRTR
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPRHTHTVKRGENRAVAEEEITELELQMVTYEEKALENNEYTGFKFPQILHFPVPNKVVEMEAIDENPFSSKKSAFFMKRRIGRPEPEDEEEERQDESSDDSESGTEEEKRDQQDWHFWECFYFAFRQLLFSRTWILLLQFAAANYFGDRLRTDGFNLADRIIEPGKSVLGDLVVRRALLGLRRWDAQQFLFVADNHYIFEHSLAFFPGYPEVINIFRIGIHEYMKGSLGWSFPPWVITGILSVAVNLFFFHAAGLALFMAVTMMTRNVKQALLAVSIFAYNPASIFFTSAYSESVGVVYFKPLTILFQLFFALTITGFNFMLYAVRATSYSQRVIGTLSGTVIFGLSAVVRSNGLLNVIFVVWYWAAILLWEPEKPVPDCHLMIESLAGSKNDRYRREGQARLRAFERKRKQTRKVFRWTDPRFSRCSLVFITLVFIVIVSIASFGPYVFMSNSAAEEFCEATPRQKELVATVKKQIRMSPKIITIADAWEKAAWCRKPKLFGIVRQYYGEIQAKYWNVGLFGYWRIKKIPCFLMMLPAAILTVLAIISAWVHVFETKRWNNIWVLLIRSDHLLHLAPQAIIMLCTAVFVINAEVFTRLIFSSSPLLYIFIAQYIDKLTQGNTMGNRLWHYTSSPGILPFFVFRRVWEEGWKGKALYIYILGYFIFGTMAHAAWLPFT
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGRGKIDIKLIENVNNRQVTFSKRRAGLLKKAGELSVLCDSEVAVIIFSSTGKLFEFSSTSMKQTLSRYNRCVASTDNSAVEKKSEDNEQPQSQQQTHVLKQEQKEVDSLKDELAKLKMKQLRLLGKDLNGMGLNELRLLEHQLNEGLLAIKERKEELLIQQLEYSRKQEERSALECEALRRQGGSFLTQLLLPSHELQVEELRGLFPLSASLPPPFLEYDRPLEKKYSILKESKESLDSDTACEDGVDDEDSNTTLQLGLPTICRKRKRTEQESPSSNSENQGGSK
The following text describes a protein:
Function:
Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety in natural or engineered linear fusion proteins, irrespective of their size or the presence of an N-terminal extension to ubiquitin.
Miscellaneous:
MISCELLANEOUS: Present with 8970 molecules/cell in log phase SD medium.
Sequence:
MDLFIESKINSLLQFLFGSRQDFLRNFKTWSNNNNNLSIYLLIFGIVVFFYKKPDHLNYIVESVSEMTTNFRNNNSLSRWLPRSKFTHLDEEILKRGGFIAGLVNDGNTCFMNSVLQSLASSRELMEFLDNNVIRTYEEIEQNEHNEEGNGQESAQDEATHKKNTRKGGKVYGKHKKKLNRKSSSKEDEEKSQEPDITFSVALRDLLSALNAKYYRDKPYFKTNSLLKAMSKSPRKNILLGYDQEDAQEFFQNILAELESNVKSLNTEKLDTTPVAKSELPDDALVGQLNLGEVGTVYIPTEQIDPNSILHDKSIQNFTPFKLMTPLDGITAERIGCLQCGENGGIRYSVFSGLSLNLPNENIGSTLKLSQLLSDWSKPEIIEGVECNRCALTAAHSHLFGQLKEFEKKPEGSIPEKLINAVKDRVHQIEEVLAKPVIDDEDYKKLHTANMVRKCSKSKQILISRPPPLLSIHINRSVFDPRTYMIRKNNSKVLFKSRLNLAPWCCDINEINLDARLPMSKKEKAAQQDSSEDENIGGEYYTKLHERFEQEFEDSEEEKEYDDAEGNYASHYNHTKDISNYDPLNGEVDGVTSDDEDEYIEETDALGNTIKKRIIEHSDVENENVKDNEELQEIDNVSLDEPKINVEDQLETSSDEEDVIPAPPINYARSFSTVPATPLTYSLRSVIVHYGTHNYGHYIAFRKYRGCWWRISDETVYVVDEAEVLSTPGVFMLFYEYDFDEETGKMKDDLEAIQSNNEEDDEKEQEQKGVQEPKESQEQGEGEEQEEGQEQMKFERTEDHRDISGKDVN
The following text describes a protein:
Function:
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MNKTLILALSALLGLAACSAERVSLFPSYKLKIIQGNELEPRAVAALRPGMTKDQVLLLLGSPILRDAFHTDRWDYTFNTSRNGIIKERSNLTVYFENGVLVRTEGDVLQNAAEALKDRQNTDKP
The following text describes a protein:
Function:
Acts as a co-chaperone and mediates the association of the chaperones HSP70 and HSP90 probably facilitating substrate transfer from HSP70 to HSP90. Stimulates HSP70 ATPase activity and, in contrast, inhibits HSP90 ATPase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MPNAAADAKKNEGNEAFKNQDYSTAVAKYSEAIEIDSSNHVYFSNRSAANAGWGKFQEAANDAAECVRINPQFVKGYHRHGVALKGLKKYDEALATLRAGQRVDFNNADLNRLVTEIEPLQARAEQAKRSGMNPAELLKERGNDAFKNAQFEKAIEVYGEAIEACSDKPGSALALSCYNNRAACNQQLSNFSGVIRDCTHVLEYDEKNQKALLRRALAYEGLERYRLALQDIRSLLAINPSIDIANKAQHRLSNYVRQLKQNN
The following text describes a protein:
Function:
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, migration and protein trafficking. Promotes ADAM17-mediated TNF-alpha processing through recruitment of ADAM17 to tetraspanin-enriched micro-domains (TEMs). Forms a complex with RICTOR and integrin alpha3/ITGA3 to mediate mTORC2 activation and AKT1 phosphorylation leading to cell migration. Reduces apoptosis and autophagy induced by high glucose levels through forming a complex with mTOR and RICTOR. Contributes to the maintenance of intestinal epithelial barrier and plays a role in the regulation of intestine inflammation by switching interferon gamma receptor 1/IFNGR1 from clathrin-dependent to lipid raft-dependent endocytosis route to limit STAT1 activation magnitude and duration. Acts as a modulator of the endothelin axis by associating with endothelin converting enzyme ECE1 and regulating its activity of conversion of the endothelin-1 precursor to endothelin.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAGVSACIKYSMFTFNFLFWLCGILILALAIWVRVSNDSQAIFGSEDVGSSSYVAVDILIAVGAIIMILGFLGCCGAIKESRCMLLLFFIGLLLILLLQVATGILGAVFKSKSDRIVNETLYENTKLLSATGESEKQFQEAIIVFQEEFKCCGLVNGAADWGNNFQHYPELCACLDKQRPCQSYNGKQVYKETCISFIKDFLAKNLIIVIGISFGLAVIEILGLVFSMVLYCQIGNK
The following text describes a protein:
Function:
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
Sequence:
MVKAPSFEVIAGSYEEFLLGYNFSSKENQLVQSFAAHDHSASVRCVALSGPYLASGGADDRIFIYDLKSRKQHCTLTHHDATITCLQFTENHSHLISGSSDGVLAIVRVGNWQLEKVWEKAHKGAAILDIAVHNSGKLALSLGADCHLCTWNLVKGRQAYVINLSNKCKNARSLERISWAPDEVRFLLYGGKFTEIWSIETGGVLKQVEHGEKVTACVWLSDSVLLVGHENGEVSVLNLEDNSTEVFKAHGSRIKGIALYKKKIITISSGGEIKVWNKDFEELAVIESGCRLTCLCVVPPVKVKSEENTNEESVSQTNTEVTENKKIVKAQVVEEIEDNDEEIQVRKSKKKKVVLEGHEQRVKKKKKKT
The following text describes a protein:
Function:
Acts both as an enzyme and as a c-di-GMP sensor to couple transcriptional activity to the c-di-GMP status of the cell. Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG. Also acts as a transcription factor to control its own expression.
Miscellaneous:
MISCELLANEOUS: An overexpressed EAL domain (residues 77-362) has similar KM, Vmax, pH and metal dependence and subunit composition as the full-length protein.
Sequence:
MNSCDFRVFLQEFGTTVHLSLPGSVSEKERLLLKLLMQGMSVTEISQYRNRSAKTISHQKKQLFEKLGIQSDITFWRDIFFQYNPEIISATGSNSHRYINDNHYHHIVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVMKAGG
The following text describes a protein:
Function:
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
Subcellular Localization:
Cytoplasm.
Sequence:
MPESRTVALVTLGCARNEVDSEELAGRLEADGWKLVDDAEEADVAVVNTCGFVEAAKKDSVDALLEANDLKGHGRTQAVVAVGCMAERYGKELADALPEADGVLGFDDYADISDRLQTILNGGIHAAHTPRDRRKLLPISPAERQEAGAAVALPGHGPTDLPEGVAPASGPRAPLRRRLDGSPVASVKLASGCDRRCSFCAIPSFRGSFISRRPSDVLNETRWLAEQGVKEIMLVSENNTSYGKDLGDIRLLESLLPNLAEVDGIERVRVSYLQPAEMRPGLIDVLTSTEKVAPYFDLSFQHSAPNVLRAMRRFGDTDRFLELLDTIRSKAPEAGVRSNFIVGFPGESEADLAELERFLNHARLDAIGVFGYSDEEGTEAATYGDKLDEDVVAERLARVSRLAEELVSQRADERVGATVRVLVESVDPAGEGDGVRGRAEHQAPETDGQVLLTSGAGLSVGRMVDAKVVGTEGVDLVAEPLLGSPEWSEEAGR
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MIVESNRVDHQNPVNDRRCSRFLRRPAVVLAISLLFVLIEKRGEEFTVSNACKSTRFPDVCLSSLARSQIAKSGPRELLEETTRAAIQGAAFDDCSELLGSAIAELQASLEEFVQGRYESEIADIQTWMSAALTFHDTCMDELDEVSGDPEVKRLRAAGQRVQKLISNALALVNPMVAAWRASLAARGQRGSAPPALVTAGRGLVNGAHVVDAVVAQDGSGQFGRIQDAINAAPRMSARRYVIHIKAGVYREYVTVRSFHTNLMFVGDGQGRTIITGNKNVMQPGITTRTSATVVIEGKNFMARELTIENTSGPQAQQAVALRVGADQAAFYRCSIHGNQDTLLAHVFRQFYRECTVTGTVDFVFGNAAAVFQNCSFESKVPVHGQQTVVSAQGRSDPAQNTGFSFHMCRVGGAFPVYLGRPWKEFARVVWLRSQMEAMVQPRGWLSWEGGSFGLQTSYFAEYKNWGPGSSMRDRVKWVKVLNGPRLARKFTPSSFIAAQSWLPKTSFIFDSKL
The following text describes a protein:
Function:
Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit.
Sequence:
MSDLAKHFAKTKLSSLPPPEPLLEEAPEYEDDSSSASSMSSTGTVIPTSTQRPAPAIHWSDYFEQEIYLDGGALSNGGHAKWHVYITPPANSKAPLLVLHHGAGSSAMSFALMAKEVKKGMPELGILAVEARGHGSAVWDAEGNVDNDLSVENLTEDLQHMLELTKVKLGWTVLPPIVLVGHSLGGAVVTHMANSGMLNSCLLGYAVLDVVEGSAMEALKHMQTDGRWAWRTELGSTEAYWENWFTGMSVKFLKGKGAKLLVLAGTDRLDKELMIGQMQGKFQLQVFPNAGHFLHEDQPDKTAEVVIEFVKRNDRSAMVLPPKVSDLLRQGRKV
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Sequence:
MTTSHTPEPKEVEDYQEDGEILDDDDDVPTEIPNITSEFLVNYPSSEDEKSPEDVIKAYKRKIENQKNVENEESVIPAIDPKLCKVCLKNEHKYKCPRCEMRTCSLDCSKKHKADNNCDGVRQAFTKVDKLSQYDPQKSIDDQKFMHLMKEKVGLGAEPVGGVGNDVNSSDGEEKPVDPNALRYTTNSPTERYLLNAARFRHIWLGFVGEQENESRHEQHSDTIFWTLKLSFKKQTADGGIEVFEKIVNNIPETIRVATVLKQFFKPRQYGCIVSESDLDVEKLKPFIDRGIDDVNVYMEVHANPERYYGIITDSTILEMTRTRVVADFPKLVITMKDEFIESMQLLSMEELAEIQTKYGGVGNQRFGGGGRGRGGRGFHRGGANRGGGGSNHNIFRKRPGQDGGQDGGFKRGRGGNFHGGSRRGGYQNRTHQNIDTFDPFEPFSGPNRLPMEYN
The following text describes a protein:
Function:
Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MSGELPPNINIKEPRWDQSTFIGRANHFFTVTDPRNILLTNEQLESARKIVHDYRQGIVPPGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTV
The following text describes a protein:
Function:
Component of a protein complex required for cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Involved in germline stem cell transit amplification, differentiation and mitosis-to-meiosis transition.
Subcellular Localization:
Nucleus. Note=Concentrates in the histone locus body.
Domain:
The HEAT repeats have been determined based on 3D-structure analysis and are not detected by sequence-based prediction programs.
Sequence:
MDSIIGRSQFVSETANLFTDEKTATARAKVVDWCNELVIASPSTKCELLAKVQETVLGSCAELAEEFLESVLSLAHDSNMEVRKQVVAFVEQVCKVKVELLPHVINVVSMLLRDNSAQVIKRVIQACGSIYKNGLQYLCSLMEPGDSAEQAWNILSLIKAQILDMIDNENDGIRTNAIKFLEGVVVLQSFADEDSLKRDGDFSLADVPDHCTLFRREKLQEEGNNILDILLQFHGTTHISSVNLIACTSSLCTIAKMRPIFMGAVVEAFKQLNANLPPTLTDSQVSSVRKSLKMQLQTLLKNRGAFEFASTIRGMLVDLGSSTNEIQKLIPKMDKQEMARRQKRILENAAQSLAKRARLACEQQDQQQREMELDTEELERQKQKSTRVNEKFLAEHFRNPETVVTLVLEFLPSLPTEVPQKFLQEYTPIREMSIQQQVTNISRFFGEQLSEKRLGPGAATFSREPPMRVKKVQAIESTLTAMEVDEDAVQKLSEEEFQRKEEATKKLRETMERAKGEQTVIEKMKERAKTLKLQEITKPLPRNLKEKFLTDAVRRILNSERQCIKGGVSSKRRKLVTVIAATFPDNVRYGIMEFILEDIKQRIDLAFSWLFEEYSLLQGFTRHTYVKTENRPDHAYNELLNKLIFGIGERCDHKDKIILIRRVYLEAPILPEVSIGHLVQLSLDDEFSQHGLELIKDLAVLRPPRKNRFVRVLLNFSVHERLDLRDLAQAHLVSLYHVHKILPARIDEFALEWLKFIEQESPPAAVFSQDFGRPTEEPDWREDTTKVCFGLAFTLLPYKPEVYLQQICQVFVSTSAELKRTILRSLDIPIKKMGVESPTLLQLIEDCPKGMETLVIRIIYILTERVPSPHEELVRRVRDLYQNKVKDVRVMIPVLSGLTRSELISVLPKLIKLNPAVVKEVFNRLLGIGAEFAHQTMAMTPTDILVALHTIDTSVCDIKAIVKATSLCLAERDLYTQEVLMAVLQQLVEVTPLPTLMMRTTIQSLTLYPRLANFVMNLLQRLIIKQVWRQKVIWEGFLKTVQRLKPQSMPILLHLPPAQLVDALQQCPDLRPALSEYAESMQDEPMNGSGITQQVLDIISGKSVDVFVTDESGGYISAEHIKKEAPDPSEISVISTVPVLTSLVPLPVPPPIGSDLNQPLPPGED
The following text describes a protein:
Function:
Transcription factor. Modulates expression of target genes by binding to regulatory elements. Required for normal cell division timing and cell positioning in anterior lineages, acting in a cell-autonomous manner. Required for development, fusion and fate of cells of the ventral epidermis, the Pn.p cells, during larval development; acts in concert with homeobox genes lin-39 and mab-5. Required for the specification of the AIY interneuron. In complex with TCF transcription factor pop-1, positively modulates expression of LIM/homeobox protein ttx-3 in anterior daughter cells of the SMDD/AIY neuron lineage.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localized to nucleus during interphase in cells giving rise to SMDD/AIY neurons, then in cytoplasm just before cell cleavage.
Sequence:
MSIPANTIQKDKMMHSDYYTQSQGPTVEQQPEWQASVQPYSDPHAYSPSFYMNMSQVPHFLPAQVDPFIYPNTLGSYGGDKQVQCLWETNGQVCMHVCQNSGELSTHISSNHITHDSKFVCLWKGCDREFKMFKAKYKLVNHMRVHTGERPFLCDVCNKVFARSENLKIHKRIHSGEKPFQCTHNGCTKLFANSSDRKKHMHVHSSHKPYSCMYPDCGKTYTHPSSLRKHTKVHENEKKSQLSPEHDESSDSGNASIGTPTTDESLTFSPENIKRDQHLHTMHTFMDRPNPFMQMYQNQFSNPTYHMFMAKPDSY
The following text describes a protein:
Function:
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MASNTLMSYGIAPVYPSILSSSKSKFATALPVSTGVTNDTSRFSMSANWMPGQPRPSYLDGSDPGDFGFDPLGFGEVPENLERYKESELIHCRWAMLAVPGIIVPEALGLGNWVKAQEWAAIPGGQATYLGQPVPWGTLPTILAIEFLAIAFVEHQRSMEKDSEKKKYPGGAFDPLGYSKDPAKFEELKVKEIKNGRLALLAFVGFCVQQSAYPGTGPLENLATHLADPWHNNIGDVIIPKGIFPN
The following text describes a protein:
Function:
5'-3' exonuclease acting preferentially on double-stranded DNA.
Sequence:
MPNKILLVDGMALLFRHFYATSLHKQFMYNSQGEPTNGIQGFVRHIFSAIHEIRPTHVAVCWDMGQSTFRNDMFDGYKQNRSAPPEELIPQFDYVKEISEQFGFVNIGVKNYEADDVIGTLAQQYSTDNDVYIITGDKDLLQCINDNVEVWLIKKGFNIYNRYTLHRFNEEYALEPQQLIDIKAFMGDTADGYAGVKGIGEKTAIKLIQQYQSVENVVENIDALSAGQRNKINDNLDELYLSKRLAEIHTQVPIDSEALFEKMSFATTLNHILSICNEHELHVSGKYISSHF
The following text describes a protein:
Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins. Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process. First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile.
Subcellular Localization:
Endoplasmic reticulum lumen. Cytoplasm. Lipid droplet. Note=Moves from cytoplasm to lipid droplets upon lipid loading. Associates with lipid droplets independently of triglycerides (TG) content of the droplets and hydrolyzes cholesteryl esters more efficiently from mixed droplets.
Sequence:
MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLKDKEVAFWTNLFAKKAVEKPPQTEHIEL
The following text describes a protein:
Function:
Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MQKSALAIALASLLTPISYLHANEAQPQETVVVTANRFEQKASSTLADVEIITRQDIEQTQAKTLPELLRRLTGVQITQNGGRGQLASLFVRGTSSDQVLVLVDGIRFARAAKGAVDFNQIPLTYVDRIEYVRGARASLYGSEAIGGVINIITKARSQQQGTTVSAGLGSLDYQELSIASGVAIGEKGQMNVALGTESDKGYNVRPVPGVNDGDRHGFRSDNALLGYVHQFDESWSLFANARAYENIYQYDNSYGTRDYKEAEKDDLSFTIGTQYQSERWVSELQLTTQKQKSWDYTQSKGKYSDTSDNLEQRNIQWINRYLVNDVWTFAGGVDWRDESYIDKTADKEFDRSNTAAFAVVAAEWQQWLLEASLRFDDNQEYGSQTTHNIALGYQFIPEFGVKASYGSAFKAPNLYQQYDPSYGNVNLQPEDADSAELSFYGLFSGIKWSITGYDYKINNLIDYNSTTKNYQNVIGESNIKGVEFTAEFATGIVQHQLSVDLKDADDSKGKTLQRRAEHMYKWNALVAFEQVDWSIGYQYVGKRPDLDYNTYPTQNITLDAYSLVDTSVSYYVTDSTTISARIDNLLDKEYETANGYPAAERAYYLNIGYQF
The following text describes a protein:
Function:
Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression.
Sequence:
MSGPLPSLNALKAFEATARHRSMTLAADELCVTHGAISRHIRGLEETLGVILVTRRAHSTEPTPEGSRLAEGLASAFGLMQASVERVRPSPLTLSCSSSIMMGWIIPRIGQFHERHPHIALQFNMNYDQIDFVRDKISLAIRSSVIDPPKDAIIRELGGEAIGPVCSPEYLNRSGISRPDDMEHAAILSTQTRPQAWSDWQAIAGQADLRLTPQAAFDHFYLLIQAAACGLGMAVVPQMLVLDQLASGRLVAPFGFLPSPRRMVLWIAPHIAGRPDALALERWLTAEMHARPDT
The following text describes a protein:
Function:
Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVIPRVYVGNASVAQDITQLQKLGITHVLNAAEGRSFMHVNTSASFYKDTGITYMGIKANDTQEFNLSAYFERAADFIDQALAHKNEASWVHGSFPIQAIPKENSLPLDLEKFY
The following text describes a protein:
Function:
BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes. Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'-(C/A)(A/G)AGGG(G/A)-3'. Controls the expression of the conidiophore-specific phenol oxidase ivoB. Controls the expression of the hydrophobin rodA. Mediates the developmental switch from the indeterminate, apical growth pattern of vegetative cells to the budding growth pattern of conidiophores. Expression of brlA leads to activation of abaA, wetA and stuA, cessation of vegetative growth, cellular vacuolization and spore formation.
Subcellular Localization:
Nucleus.
Domain:
Both zinc fingers are required to induce development.
Sequence:
MRNQSSLSDRLTVEVDCSSLGSNECPSMTSSFSPLESPTPTPTSIYSQGSLESPGWHGAGSLPNNTYERTPGSASMRSAFRLAGMASTESLGLPYGSMEGQERMPMPDFLSGYDENIEQLWMPSEAPKSYDHVAQGLAYHQGMHQYPTMARNTNNNYRHQAAAYLPESTTNPCLSRSIFHQPERVPSSMSSSMSMNNMLPWMNLGDSIAPQTIAPSQVGPVTPPPSYTDFPTSLSAFKQHSPTTPIRSCSLGTGSGADTPLSRLSGGPCEYMDDFQPSPVYRDGFQRPHRVASRKMLRRQTSKQNLMLENLPQVIKQVQFKCKEPGCNGRFKRQEHLKRHMKSHSKEKPHVCWVPGCHRAFSRSDNLNAHYTKTHSKRGGRNRYVATLDENSPDYDPEFRGQLTPDGRPIYGSKLDDPIPGAGDMSLDGWDE
The following text describes a protein:
Function:
Essential for the invasion of host erythrocytes by blood stage merozoites. Required for the assembly of the PfRH5 adhesion complex (or invasion complex) composed of CyRPA, RH5 and RIPR at the interface between the merozoite and the host erythrocyte membranes. This facilitates the binding of RH5 to host receptor BSG/basigin, which leads to the establishment of a tight junction between the merozoite and host erythrocyte membranes and allows Ca(2+) release into the erythrocyte.
Subcellular Localization:
Secreted. Cytoplasmic vesicle, secretory vesicle, microneme lumen. Cell membrane; Peripheral membrane protein; Extracellular side. Host cell membrane. Note=In late schizonts, colocalizes with RIPR in the microneme lumen. During merozoite invasion of host erythrocytes, secreted at the merozoite apical surface where it colocalizes with RIPR and RH5 at the interface between the merozoite and the erythrocyte.
Sequence:
MIIPFHKKFISFFQIVLVVLLLCRSINCDSRHVFIRTELSFIKNNVPCIRDMFFIYKRELYNICLDDLKGEEDETHIYVQKKVKDSWITLNDLFKETDLTGRPHIFAYVDVEEIIILLCEDEEFSNRKKDMTCHRFYSNDGKEYNNSEITISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKDDNKKDDILCMASHDKGETWGTKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGDNINNVKNVNFIECTHEKDLEFVCSNRDFLKDNKVLQDVSTLNDEYIVSYGNDNNFAECYIFFNNENSILIKPEKYGNTTAGCYGGTFVKIDENRTLFIYSSSQGIYNIHTIYYANYE
The following text describes a protein:
Function:
Transcriptional activator of the fuc operon.
Sequence:
MKAARQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNELQTQGKILRNHGRAKYIHRQNQDSGDPFHIRLKSHYAHKADIAREALAWIEEGMVIALDASSTCWYLARQLPDINIQVFTNSHPICHELGKRERIQLISSGGTLERKYGCYVNPSLISQLKSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDERQVATSLVTA