lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional activator.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MWRAEGKWLPKTSRKSVSQSVFCGTSTYCVLNTVPPLEDDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGSSVHHKCNSAKHRIISPKVEPRTGGYGSHAEVQHNDVSEGKHEHSHSKGSSREKRNGKVAKPVLLHQNSTEVSSTNQVEVPDTTQSSPVSISSGLNSDPDMVDSPVVTGVSSMAVASVMGSLSQSATVFMSEVTNEAVYTMSPTTGPNHHLLSPDASQGLVLAVSSDGHKFAFPTAGSSESLSMLPTNVSEELVLSTTLDGGRKIPETTMNFDPDCFLNNPKQGQTYGGGGLKAEMVSTNVRHSPPVERGFSFTTVLTKEIKTEDTSFEQQMAKEAYSSSAAAAASSSLTLSAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYTSSFSQTGHSPHVHQTPSPSFFLQDASKPLPLEQNAHSSLNDSGGTFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMAAEGEVTMETSQVAEGGEGLIKSGELQACSSEHYLQPETTGVIRSAGGVPILPGNVVQGLYPVAQPGLGNASNMELSLDHFDISFSNQFSDLINDFISVEGGSSTIYGHQLVSGDSTALSQSEDGARAPFAQAEMCIPCCSPPQGSLQLSSAEGGAGTMAYMHVAEVVSATPAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMTGSQQHKQGSGGGSSGGGNGTGNGGSQAQCASGPGTLGSCFENRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQLGQNPRIHCPPSEEPNTDSWMTQWHSEAINSPEIPKGVTVIASTNPELRRPRSEPSNYYSSESHKDYPAPKKHKLNPEYFQARQEKLLSTALSLEQPNIRKQSPSSKQCVPETISPSEGVRDCIRETSPPTPETAGFQASGSQPVVKWNSKDLYIGVSTVQVTGNPKGTSVGKDAAPSQVRPREPMSVLMMANREVVNTEMGSYRDSAESAECSQPMDEIQVNMMTLAEHIIEATPDRIKQESFVPTEPSALERTDTATISSTMSWLASYLADVDRLPSATQIRSAYNEPLTPSSNTSLSPVGSPVSEIAFEKPSLPSAADWSEFLSASTSEKVENEFAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKKFQQSRRAAVLIQKYYRSYKKCGKRRQARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHSPLVDHRLYKRSERVEKGQGT
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSQLKKTNLNSVNDLRQTTDDHLGLVFQQLGYNESFTLIDLKLGLGLSTVVIAGLLFLVDKKYAWKDSYNLTVIACVLYGIISGVLYLINFFNKNVKYIGYDNKGNKLSVATSSNKLDPIYNVTISLNDRSVNAAFGFNKFFDVVGFFNRDAFTKLVENELNKLNKKNE
The following text describes a protein:
Function:
Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins (By similarity).
Sequence:
MAFSGALTITDLDDFLTPSQACIIPVRNNKKPAEDEGPTEIHIDSNNNYYEVSTYPSVGHDDDIGNSKKALEKAEINLNDCLACSGCITSTESLLITMQSQNEILEFIKTNPTVVDPESPCHKPRLPILSISPQTLASLSAAYATASSRPPIPLLVLLRRIRAFLSQPEKGSWRVWDTTFARHMSLRESVVEFHERKDKKEKGKAAEMPMLASACPGWVCYAEKAQGDMLPLLSAARSSQGIIGALAKSWYGHKLQHKPDEIYHVTAMPCYDKKLEASRSDFYSSLYSTRDVDCVLTTGELDLLLQELGFDPHVPIANESTPSYSATEDSPFPELLTHEGSSSGSYLQTIIHDVQRSHPNPTRIITREIRGSTDNIEYLIQDTITGQIVFKGAKVYGFRNLQNLVRKVAKETGIGRSGRGAGAGKLSAAVAARRRKAKTAAPAATSATTSAEGTDVESIASLSLVSGEDKKLDFVEVMACPGGCVNGGGQMKPTVPTPSAPEAMEVDEEGYQRPLPDDGVAVAVNGGSNNVGTGTVAGMEEGMRWSTKEWVAKVEDIYWTGLPTPPASPPLTASNVNGFAPQVKTNGTTNGQVNNGVDRNLQSDQLAEEIIHEVCGDDASKRWDFMRTRFRKVESDVLSSGGVTHEAVKW
The following text describes a protein:
Function:
Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPSTSPAPNATAPAAWTNISMPEMPLFHRFALLDEELYAAFPGLWLALMAVHGVIFLAGLVLNGLALYVFGCRTRAKTPSVIYTINLVVTDLLVGLSLPTRFAVFYGARGCPSCALPHVFGYFLNMHCSILFLTCICVDRYLAIVQPDGSRRWRQPACARAVCACVWLAAGAVTLSVLGVTATGGPCCRVFALTVLEFLLPLLVISIFTGRIMCALSRPGLLRQGRQRRVRAMQLLLTVLVIFLVCFTPFHARQVAVALWPDAPPRASLVAYHVAVTLSSLNSCMDPIVYCFVTSSFQATVRSLFRRHGVEYEPNSCDAVSTLQSAKGPGHRHILSTRPQAPSRALANGPEA
The following text describes a protein:
Function:
Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MEVKPPPGRPQPDSGRRRRRRGEEGHDPKEPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAMCARPHKVDGRVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGEFFLPVLKVVEGDLATLWVVAETLEVVEATLAVAETLVEEEVMVVEVVAAGVVMEEAMVDIMDLEVMVATMVVVLVIVVEEAMVVVDQDMGTKVVDMVAVVEDMMVTMKEEILEVVTMVVVGTIMILEIIVDNNNQIMDP
The following text describes a protein:
Function:
May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.
Subcellular Localization:
Sarcoplasmic reticulum lumen.
Sequence:
MGHHRPWLHASVLWAGVASLLLPPAMTQQLRGDGLGFRNRNNSTGVAGLSEEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGNYQPGSLCGYCSFCNRCTECESCHCDEENMGEHCDQCQHCQFCYLCPLVCETVCAPGSYVDYFSSSLYQALADMLETPEP
The following text describes a protein:
Function:
May play a role in retention of a subset of membrane proteins in the early Golgi compartments.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Note=Early Golgi.
Sequence:
MIVLNALSYLGIVLGFIGMTVSIASALYYISEFVEEHSRLAKAFLCRLVYFIMAVMVFLVIFDGFPFWLSAFSIFSHYIYKINFDTFPFFSFKRMRFLLACFLIVANHILWVRFFQVHEFPIKPRGLTYDFVGQRLLTSRASFSQVASFMGVCVWSVPIGIFVSFTAADNTLPTITTPSSSSPDAYSSGSSRRTSNVLRQAYKKLGIFVERSLTSLGLSDRSSERYV
The following text describes a protein:
Function:
Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Also participates in viral entry at the fusion step probably by regulating the core fusion machinery.
Subcellular Localization:
Virion tegument. Virion membrane; Lipid-anchor. Host cell membrane; Lipid-anchor; Cytoplasmic side. Host Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Sequence:
MGAELCKRICCEFGTTSGEPLKDALGRQVSLRSYDNIPPTSSSDEGEDDDDGEDDDNEERQQKLRLCGSGCGGNDSSSGSHREATHDGPKKNAVRSTFREDKAPKPSKQSKKKKKPSKHHHHQQSSIMQETDDLDEEDTSIYLSPPPVPPVQVVAKRLPRPDTPRTPRQKKISQRPPTPGTKKPAASLPF
The following text describes a protein:
Function:
Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MAKFSLPAADLTRSEENNDTEAAVHQDAVYDEYADRDIPLPSFKRKDDLSNSEPKPAKKKKQVLKRQTEQEDVDPISTEAPLSLDSIKRREARDDVDAVMRKIKPKRNKRDLQDEAEIDEFMDAMLNKMKEAASNDQEFNKNKQPAIAKLKLLPSVLDLLSRQVITWYSQFLENNILEGIKLWLEPLTDGSLPSLDIQKGMMETLSKMPIETHHLRHSLVGRIVMFYTKCDRVTPSIRRIANDLIRRWMRPILKRSANYKDQELQEVRINSLETRPFKKQRPQASESPSSQSIMSSVRARIPMPVAPSFTVIPVSNVPQIGNGEKRVDKYRKLKSTMKMIKSRNAK
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of [LysW]-aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLRVSIVGASGYVGGELLRLLLDHPHVSIIQATSARNAGRYLYQVHPNLRGRTNLQFVHPDTLQPCDVLFLALPHGEAAQAIERYASLAERIIDCSADFRLRDPAVYQQWYGSAHPAPAWLERFVYGLPEVNRAALTGARYASGVGCNATATNLALLPLVEANLIDRSRPIIADVKVGSSEGGATVNEASHHPERSGAVRSFAPVGHRHLAEVEQVTGLRNVHLSITAIELVRGALATVHAFASRELSEKELWQAYRTFAREQPFIRIVKERQGIYRYPEPKILAGTNYADIGFAYEPATGRIVSICAIDNLMKGAAGSAVQCMNLMCGFAETTALTFAGLHP
The following text describes a protein:
Function:
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Membrane; Single-pass type I membrane protein. Mitochondrion.
Sequence:
MCIRVMESDCRIPMSCLRPRILALHALFWGLVSLRVFGAALLSDEKTAVAVTKAMTAPCWQLEEFVVAKECSVCEGLQLKTIPACSQTGFIEKINCTKSNRDEYKRGSKVAQWVAQSPHSKKVFGSSPGWVSWLFCEEFECSPWLSLNKNGGASVLEI
The following text describes a protein:
Function:
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MQAVVPLNKMTAISPEPQTLASTEQNEVPRVVTSGEQEAILRGNAADAESFRQRFRWFCYSEVAGPRKALSQLWELCNQWLRPDIHTKEQILELLVFEQFLTILPGEIRIWVKSQHPESSEEVVTLIEDLTQMLEEKEDPVSQDSTVSQEENSKEDKMVTVCPNTESCESITLKDIAVNFSRGEWKKLEPFQKELYKEVLLENLRNLEFLALFENHRNYIPYNPKYNSFLSCKQEIFYFLYLLDESALDKIIERCLRDDDHGLMEESQQYCGSSEEDHGNQGNSKGRVAQNKTLGSGSRGKKFDPDKSPFGHNFKETSDLIKHLRVYLRKKSRRYNESKKPFSFHSDLVLNRKEKTAGEKSRKSNDGGKVLSHSSALTEHQKRQKIHLGDRSQKCSKCGIIFIRRSTLSRRKTPMCEKCRKDSCQEAALNKDEGNESGEKTHKCSKCGKAFGYSASLTKHRRIHTGEKPYMCNECGKAFSDSSSLTPHHRTHSGEKPFKCDDCGKGFTLSAHLIKHQRIHTGEKPYKCKDCGRPFSDSSSLIQHQRIHTGEKPYTCSNCGKSFSHSSSLSKHQRIHTGEKPYKCGECGKAFRQNSCLTRHQRIHTGEKPYLCNDCGMTFSHFTSVIYHQRLHSGEKPYKCNQCEKAFPTHSLLSRHQRIHTGVKPYKCKECGKSFSQSSSLNEHHRIHTGEKPYECNYCGATFSRSSILVEHLKIHTGRREYECNECEKTFKSNSGLIRHRGFHSAE
The following text describes a protein:
Function:
Esterase; part of the inp gene cluster that mediates the biosynthesis of fellutamide B, a mycotoxin that acts as a proteasome inhibitor. In the first step of fellutabmide B biosynthesis inpC activates 3-hydroxydodecanoic acid to generate 3-hydroxydodecanoyl-AMP that is then loaded onto the T0 domain of inpB. The 3-hydroxydodecanoyl-S-phosphopantetheinyl-T0 is sequentially extended with L-Asn and L-Gln by the two CAT modules of inpB. The linear lipodipeptide from inpB is then transferred onto inpA for the addition of the third amino acid, L-Leu. Reductive releasing of the lipotripeptide by the TE domain of inpA produces (2S)-fellutamide B. InpF might be involved in the release and transfer of the lipodipeptide from inpB to inpA. The inp cluster-encoded proteasome subunit inpE confers resistance to internally produced fellutamides. The MFS efflux transporter inpD may contribute to fellutamide resistance as well.
Sequence:
MRILFFHGHTQTGPVFERKTVRLREHIQRAYPGSTFFFPTGPIAYKVSDRLDYLSEIQRERSDNFKDPDLIETHAWFRLFEDDPPRGLLESLDIAAEILRVEGPFDGVICFSQGSVVGSMMASLLEGPRRRQRFDEYAASFPGAVRYPKSYKNINHPPLKFGITYGAYMGTSPVFNAFYSEPLIETPFLHFMGEFDPVVPSEMVAAVDKAQIGGSRRRKVMHPGAHAIPVGDRYHEAVVDFIRSACETSPTYFDLPSDEVPLLSYNDTPEQTPFQTPLLTPSLSSAVSTTSIPSSEATILATRRLDQWEKSRSPRSNIRPRSTRRTVFSGRRSTSSSAESSAASQHSDHFEATRTPTSSTSTVQMIEPTVNKEPNLAVRVVEDDTIVSGSEYEGEGWQELLLSDLLNEMLRRHGRPGRFYFVPDGEGGRLENGMRLN
The following text describes a protein:
Function:
Receptor on natural killer (NK) cells for class I MHC.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MSEQEVTYTTLRFHKSSGLQNPVRPEETQRPRDVGHRECSVPWKFIVIVLGILCFLLLLTVAVLVIHIFRDGQEKHEQEKTLNNLRQEYQVMKNDSSLMEEMLRNKSSECKALNDSLHYLNREQNRCLRKTKIVLDCSQNKGKQVEGYWFCCGMKCYYFIMDDKKWNGCKQICQDYNLTLLKTNDEDELKFLKSQLQRNTYWISLTHHKSKEESQQIGDRPSKLDSAARNSVPNRQKCAYLSSFSTEEDDCARTHGCICEKRLNKFPIPGSCAKGRTQSALQRDEDES
The following text describes a protein:
Function:
Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity).
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MSSSNQVKGFYFNAQRRLSRAQALCQNSQDTLHNMQLLLVRWQRTVSKLQFTIHCICNQTVFLAECILKKTVGQQLIETEWKRMLLDELQGEMQRSQEEITGKIDALRRTKNELDGSGATLADFISMENIFLLGDKLKDVPVVQEQVEHIKVQYESLVDKVVEQLQNNRVRKLEADFAAAFRSGKNDFNAFSMKYLQKIRQLETDLADILKSLTDHYDKCSLLKAGDLPAAEQAELFEVVKNDDQELDSIMGVLEVIVRDIKSLAKNVSIRLRQKERDKQQLKNAMGKAHSELLKYEEHLTVFQGIDDLIRNFKASCLHNVSKVRELCEFYDNFLNSYQVLLREVERRRRVAKQMEDILQACEGQLMALSDTDLKQRQQFLMRHGDYLPENIWPGNIDDLSPLYDLEYRIKKV
The following text describes a protein:
Function:
First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.
Subcellular Localization:
Nucleus.
Sequence:
MDLRTIMNSDATGTSDAAPAPSQQSLSRTESVYPPRQPQNVTASPSSSSSSHPPGSQQQPPPLQRPHASPERSSSYGSIQSPFQYHSASALSAGAQSQRGQSPPPPAPPFASSGSRDSYSASASYNTAASLASPYTPQPASSTGPFPEQQQQQSYFAQQRSQSIQSVLSPPPATNHSFPPRDSPSSAASQSHPSQLFSPPAHGSLPGTPRASATTSLPRQTTPSTRPQSSGHDSQSHHGSSPWVGPDSQVHMSPTSMPRASRQDSRHRELTPRQFPPRVDRRASDESVSPKTAYPAASRQGSVTSTSEQRFAAQSSRVGDGETRENSAASIMNMSQSSVAPGDARTAPTTSRINSSPSSQSFKPNESLTGDAFPTKMDVPPDFRPDSSDRPAKRRRRRYIEPPIFAQRSVRTKGRCPMIPNPLPPIPKHLRDSPQNPFEARRQSTPSQAPAATVAPSTAATAVTKSEPPPVNGPPAARLPPTPAASALPVGSLGPWEPSITGFIPHEEITKLVCDFLFQHVVLRNDATAAPAGTAAAGQGAIIEVEAKLGHIIDMDRGERLSLPILTESVINKENPRFRTAFESSMTLSQHRAMNNFLNEAVKASMPQTNQGRIPLSYAHKKERDTFYEISPSELPPVIRQNLNPRHKPKVRVTVDQRTGEVLAKIVKCRIADMDVHSPRTSVDWRVSVNLEMSYDGDVSHLPMVDSRGGRGGDRSKDRMSYRHLAYQIDLTQVAKSEPPSKGDFEHELEIEASAAEIRRQGQLAMAGDPQNQYEDLVKGFVDNIRVLARAVPPPS
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MPAPATTTPAGKKTTPTEKAKVLPDSKKVQPEVALEDDDDFEDFPAEPWTDADQELGSLHQWEDTWEDDDEAEDLAIQLKAEEKKRGVAPMRM
The following text describes a protein:
Function:
Receptor for basic fibroblast growth factor.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MDFLNSWFRTGFLHRTGLRRLPRLSQMNWTGTLFLLATLWTLGSTQEPLSSTTVVLVGYPAVLSCGYASEQPPASVDWYRLEGLDADQERTHLLYHDSNSGTFAFGNYSDRATVVDDANLRLDTVYMSDNGDYECEVPTTEDYDTFLSKVRLQVLESPDGPRITGYSPPLLAGQTLHLRCESQIVGDVRPTLVWYNGSQELSRVEPSVWQPDTTTAVLNYVLDVSKYDNAKPYRCQAMYRGPVGVREQKVTLDIRYAPTTHMTYPLGTQVREGDDVLLRCGVDSNPPSTVSWERLEGAMPPNHKLYEEHHLLRIVGITRQFHGTYQCKAENSLGISTTSVRLDILYAPSIARQVWNTAEALVGENFTRTCVADGNPTPSVRWSRDGSEEVYDDPLFFSSINFTDDGSYICRARSSIPNFPDSTAKFRLDVKGPPQIVKQNTIFSAKENGSVTLECEVESDPPATRVAWKWESNSIESGTVGRYSVRQKETPTSILSTLTIKSVQASDFRSYQCLAVNVHGEETQVIVLERATAPPPQPIPLVAIVLPVILVFFMVVLGLLYYLRKYWQRKLPWTPKYLKNKDMEMRAIEDDYLPPIAQDSASPMPLLPGDDPSNYYQEPDLIRDLEFPRDKLSLERVLGRGNFGQVIKAKAQGVGGADKPMTVAVKTTKDGSSADAKEDLLKELKMMKLIPPHPNVVMLIGYCTKTEPVYVIVEYCALGNLQNFLRKCRSKRDSTYANIQVDERLLTPRDLASFIWQIARGMAHVASLKIVHRDLASRNVLIDKNKVCKISDFGLSRDVYDTDNEEYEQKTQGRLPLRWMAPESLFDHVYSVKSDVWSFGITMWEVLTLACTPYPGLSPPAMMERLRNGFRMSKPVHCNDEVYDIMRKCWEDDPEDRPTFIDLVRLLEDVITKAEDFIKIDEIPAAMYDESNSKKSKQEKC
The following text describes a protein:
Function:
Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
Sequence:
MRFSRPIQKCFMYLITGAGGQLGKELCALLEAREEPFVAYGRAQLDIADSGAVRQALEQSGAAVLFNCAAYTRVDKAESEAEEAHRVNATGARVLAEACSAAGSRLVHVSTDYVFDGSACRPYPEDAPTQPLGIYGQSKRDGEVAVLEGDGEHLVVRTAWVYGVGGPNFVRTILRLAGEREQLRVVADQVGSPTWTFDLAAALVGLTKAQAEGGIYHVTNSGVTSWYDFAVAIVEEAQALGRALKLQSVVPITTAEYPTPAARPAYSVLSNTRALRVLGGPLPQWRQSLRRMLQQLDKEG
The following text describes a protein:
Function:
May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Required for proper trafficking and targeting of the collagen-modifying enzyme lysyl hydroxylase 3 (LH3) to intracellular collagen (By similarity). Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating vipas39. In epithelial cells, the vps33b:vipas39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (By similarity). Plays a role in bile duct development.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.
Sequence:
MAQTERRDAPELPDFSLLKRLARDQLIFLLEQLPGKKDLFIDADLMSPLDRIANVTILKQHEVDKLYKVELKPIVSSSDQLCFLIRPRIQTVKWISDLVNSDKVAGRFRRYKIIFTPQKFYACETVLEEQGVYGDVTTDEWNFYILPLDDDILSLELPEFFRDNFLEGDQRWVTTGGGALHLLQSVYGSFSKVYGIGRCAKMVYESWRELMEEGEQRTRQPEFAKVFLIDRDVDFVTPLCSQVVYEGLVDDIFRIKCSSVEFGPDVTSSDKSIKVMLNSQDKVFNEIRNEHFSNVFGFLSQKAKNLQTAYDKRRGMDIQQMKAFVADELKGLKQEHRLLSLHIGASESIMKKKTKQDFQELLKTEHSLLEGFEIRECIAYIEEHINRQVSMIDSLRLLCLLSITENGLLSKDYRSLKAQYLQSYGIEHLLTFANLRQLGLLEEQQTGETLTVMESKVGKLVNDKTAGKLTDAFSSLAKKSNFRALSKRLALVPKSGEEYDLRVPRDMAYIFSGAYIPLSCKLIEQVLERDGWTGLEEVTRMLNGQDFAVTGGSSSSEARNKSNGQRIILVMFLGGCTYSEISALRFLGKERGCRFIVLTTAITNSGRLLEALLDKHV
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.
Subcellular Localization:
Nucleus.
Domain:
The JmjC domain mediates the demethylation activity.
Sequence:
MLQQVTSTTVTGADIQLRAKLLLFSMTDDQCVYCKGKMEHRMWVQCEACPQWVHVQCIPEECLSGGEYPSRSSDIAAFECSAHGTARARLALKGKRRRVEAKEEPERAGTRRYRLRKRGPLDYIALNEGQDVRLRHEHPHRAAFQGCFTKWSGLGRTVTSAELQQSFAELREPVLVADPEHSGMQTPAMDEQVLADVLGADYSLDVMDVQSQQNERWTMGQWKEYMHTARGVRDRIRNVISLEVSHVPEFGQRIRRPRAVEDNDLVDLVWPVQPAPEIGAKPKVQKYVLMSAANAYTDFHLDFAGTSVYYSLLRGAKQFLLFPPTPANLGAYKAWCADDNQGLIFLGDRLQDGVSFSLRPGDLFMIPSGFIHAVYTPEDSFVVGGNYLCLRDLSTHIRIVRIEQETQVPKKFTFPKFERVMGLTAEWLLEGLPERLQLITHEHAVALLDYLRDTRLKYKPAHYHTKSTMLASLEKALEGCEPASGP
The following text describes a protein:
Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MEDALSIDSKLIKMGATGNPNITRLATLQERKKTIEESLAKCNQELKQICLQEADLTGIIPTEMPLEPGESPPLIRRRVGTAYQLPENLIKSSKDESLKDLELQIQVHANMAEAALGLANEQNISKTLRRQHMAEYQQHKIQFTALQEKLSALKDKAQQNELHKQKKKPRPAEQDDNVSLGTNMNEPFGKSDLRHSMRSNKCDTDVEQRYLLSNPRMTYKNVTNSYMEGSFTRQEESIARGLYALSFNGYKNYIERQESLANNHIGGYSTLQYSQLQHSPVNSHYSQSYQPNPRPNTLYNYPVNQNFQVPQVIQHHSPQSTRSQHRQSSPNLNTTKMFYAQNPDYRLHSENPHQIQPHQQYEHMTLGLGGYWKRLDSGQTVWCNSSPTESNWQRDKRFGSLDRRKNKRLHKRVSPSVSSKSATLATVPVYAEQMRTPSIKSPQVISRRSQDNRQLVRTQSLGSVGGQTVDSVWPSDDNSSCESDNRSINEAGQNARKQKQKEWMETFLDGPVSPTHSVISRSQSALPSVLSPEEKYIVSPPQPIPPPQTPKPPLEIPAESNPSPRIPETNIELFNNNIPKNCTIVQAGHYKPYHEETKPFEMSDYYKYSAKFKKSPQKQQEDTLKKSQGGASFQKNLNEAFDKPVKNHNFSPGSPRLDNSVNSSFDLSQNVAERFSDEMNAWYFVNCCIYFIPNGWSKMGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSTEPPYSEARYEEIKKEVSSYIKKIGYNPAAVAFVPISGWHGDNMLEPSTKMPWFKGWNIERKEGKAEGKCLIEALDAILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVVFAPANITTEVKSVEMHHEALPEAVPGDNVGFNVKNVSVKELRRGYVAGDSKASPPKGAADFLAQVIVLNHPGQISNGYTPVLDCHTAHIACKFAEIKEKVDRRSGKTTEENPKAIKSGDAAIVTLVPSKPMCVESFQEFPPLGRFAVRDMRQTVAVGVIKSVNFKDAGAGKVTKAAEKAAKKK
The following text describes a protein:
Function:
Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Sumoylation mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAESSGSPHRLLYKQVGSPHWKETFRQGCLERMRNSRHRLLNKYRQAAGSTPGTASDRLLVQEVMEEEWASLQSVENCPEALLQLELPLDLAVLQDIEQELCNEEKSIISEYEEDLEFDESCLRRMLAEWEANSLICPVCIKYNLRIMNSVVTCPCGLHIPVHSTDLTEQKLRACLEENVNEHSVHCPHTPVFSVTGGTEEKPSLLMNCLTCDTWAVIL
The following text describes a protein:
Function:
May be a tumor suppressor gene.
Sequence:
MANGIEDLIGIPFPNHSSEVLCGLNEQRHNGLLCDVILIVQDQEYRTHKSVLAACSQYFKKLFTAGTLADQPCVYEIDFVKPDALSAILEFAYTSTLTITTANVKHILNAAKMLEIPCVINVCMEIMDPVGDEEEEEEKEEEEEEEEEEEEEEEEEDEEREGEVEDFAVQNLTDAQDGSCHQSPSKSDLAEEVYSEMQSGFSSHFPAGTPNGSLGTIRDFSIESLLRENLYPKTGLPERRPTLSPFVPDLFPHLWNGDFGTFSQVEEAQLDNGPLDLVIRKRKIKEEEKEEPSPPTPFPNSLFKDMFGSNPAGHLGHIKAENDYSAYLNFLSAAHFGGVFPQWPEERKIKPKASQQCPICNKIIMGAGKLPRHMRTHTGEKPYMCSICEVRFTRQDKLKIHMRKHTGERPYLCIHCNAKFVHNYDLKNHMRIHTGIRPYQCKFCYKSFTRSDHLHRHIKRQSCRISRPRRGRKPATWRATSLLFAPNGQPDDKSFMMPPALEEMSSHLGSAAMCLPGPSPKHFLDGAKNALNLQELESQFEETQMKLFGRTHLDMDPNGGLFAFALGHNDSLSARPFFSLPDPWSTGFGGLTGLGHLGPITEATN
The following text describes a protein:
Function:
Unknown. Required for development but not for cell death.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle membrane. Endosome. Note=Colocalizes to large vesicle-like structures with chmp4. Colocalizes with vamp7A to endosomes but not to lysosomes.
Sequence:
MLSIERKRTEKVDFSKPLTKYIKEQFSKAESDQHETQIATLNGLREDVRNLQERTETSKEMVWKYYSILSSLELRFPISENNVRISFPWTDSYRQRKSTLYSIYFERASVLFNYGSIVSQIASSTNRSNIEGVKKACNQFQLAAGVFNKLREYASLHPECSTSADFSSESLQALVTIMLAQAQECIYEKASMDNLSDSILSKLAAQVAEYYDTFNQLLNSNSLKSIVDRNWNITATVKSYLYKAISLYCHAKGLEQVSQFGEQVSRLMIAVDNINQSKVNLAKTAPIELKEIVERYVISITRYCESAKKDNDTIYHDTIPPAHKLTPIEKKPLAKALPLPEINFVDPFNSLVPFSVKEDSAYYNDQKETLLRKELDNIEFHNQSAKASLLSMGLPGSIEALDVGVPVALKEKMNVVTNEQGVSNITRLLENIQQLSDEDSAICLSAGNLLKKEEDEDNLMRATYGAQWHRTPSYTLTANLTQDYAKYTSHLQHSTKSDSFIRKKFEDHKNSIQELENQTEIIALLPTNNLPSGKIAEIASLTVLMNDLDALMANRESIAEKLKNLCKKDDITLKLLSPQKDKSLIYAEEIQKYEPLQMSLNESFLKQQKLIEDIRKENEKFTNQKSKQGNQREEILQKYANAYKVYNELKANLDEGTQFYLNFQEILNKFLNRCKDFTTGRENEKIELKRQIEAGVNPHSPLTSPSPSLQSPVNNYPNQFSSPQYHTSPNQQQQQQQQYVPSSQPPPQYSYNPQPYQPPQQFGGPLPPPQSFSAPPPPQSFTAPPPYNSNNKHY
The following text describes a protein:
Function:
Catalyzes the decarboxylation of tryptophan to tryptamine. Tryptamine is a neurotransmitter that induces the release of serotonin, which is suggested to modulate gastrointestinal motility. Therefore, the tryptophan decarboxylase from the gut bacteria Clostridium sporogenes (strain ATCC 15579) may influence host brain and behavior. Has weak activity with tyrosine. Activity against phenylalanine is undetectable.
Subcellular Localization:
Cytoplasm. Note=In vitro, tryptamine is excreted into the extracellular fluid, suggesting that the bacterium has the potential to excrete tryptamine in the host gut lumen.
Sequence:
MKFWRKYTQQEMDEKITESLEKTLNYDNTKTIGIPGTKLDDTVFYDDHSFVKHSPYLRTFIQNPNHIGCHTYDKADILFGGTFDIERELIQLLAIDVLNGNDEEFDGYVTQGGTEANIQAMWVYRNYFKKERKAKHEEIAIITSADTHYSAYKGSDLLNIDIIKVPVDFYSRKIQENTLDSIVKEAKEIGKKYFIVISNMGTTMFGSVDDPDLYANIFDKYNLEYKIHVDGAFGGFIYPIDNKECKTDFSNKNVSSITLDGHKMLQAPYGTGIFVSRKNLIHNTLTKEATYIENLDVTLSGSRSGSNAVAIWMVLASYGPYGWMEKINKLRNRTKWLCKQLNDMRIKYYKEDSMNIVTIEEQYVNKEIAEKYFLVPEVHNPTNNWYKIVVMEHVELDILNSLVYDLRKFNKEHLKAM