lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytosol.
Sequence:
MANKVAAPTEKVPRIQRVFINLLDTYSSGNIGKFLSNCVVGASLEEITEEEEEEDESKSAMQEPSSVKLKEGTFQIVGTLSKPENPRPTFAVETYSALSREDLLLRLLECDVIIYNITENSQQVEEAVWAVSALNEEVSHFERRKVFILLSTVMTWARSKSTDPDDSDIPFTEEDYRRRKQHPNFLDHINAEKMVLKFGKNAKKFVTYVVAAGLQYGLEGGILHTFFKIAWLGDVPALPVFGDGTNVIPAIHVLDLAGVIQNVIDHVPKVRYLVAVDESVHTLEDFVKCISKSTGPGKIQKIPKENAFLTKDLTQECLDHLLVHLRMEALLVKENFNIRWVAQTGFVENINNILKEYKQSRGLLPIKICILGPPAVGKSSIAEALSKHYKLHHIKLKDVISEAIAKLEAIVAPKDGGEGEEEGEEEEEEENVEDAQELLDGIKESMEQNSGQLEDQYIIRFIKEKLKSMPCRNQGYVLDGFPKTYDQAKDLFNQEDEEEEEEVRGKMLPFDRLIIPEFVCALDASDEFLKERVMNLPESVVAGTHYSQDWFLRSLSNYRDINTEDETVLNYFDELDIHPIHIDVGKLEDAQNRLAIKQLIKEIGKPRNYGLTDEEKAEEERRAAEESLAREAMQEAERERKEALEMAEKIARWEEWNRRLEEVKREERELLEAQSIPLRNYLMTYVMPTLMQGLNECCKVRPDDPIDFLAEYLFRNNPETQ
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.
Sequence:
MLTKFETSSNQVRGLSFHPKRPWILSSLHTGVIQLWDYRMTTLIDTFEEHEGPVRGVHFHISQPLFVSGGDDYKIKVWNYKTHKCLFTLLGHLDYIRTVQFHHECPWIVSASDDQTIRIWNWQSRTCVSVLAGHNHYVMCASFHPKEDLLVSASLDQTVRVWDIAPLRNKKKTPLADDDDIMGFTQMNSDLFDATVKYVLEGHDRGVNWAAFHPTLPLIVSGADDRKVKLWRTNEGRTLTKGWKEFTEAHDLRIGDIVIFKHEGDMVFHVTPFGPSCCDIQYTHPHIVKEEADADDAPTFSYDYCFLAEVTPTNQKDDKMFLPVEAMRCGALNQQCKEVKLVNKEGKSWTARFGFSESDGAYYISRGWRKFCRDNRCTNGDLFVFNVVGDGTTTPLLCVCPERKECTELLIKHFSRIDETKAWEVDTLRGHSSNVSSVMFHAKHDVIVSNSEDKTIRVWDATKRTEIKTFRRENDRFWILAAHPETNLLAAGHDSGLIVFKLERERPAFALSGDSLLYAKDGFLRRYEYSTQKDSQVIPIQRPRTVSHSPTENAALISSDLDGGSYELYIIRSGVVQRDAKRVSGGGSAVFIARNRFAVLDKSTGQEEVLVVKNLKNEVVKKIPLPIPTYAIFYAGTGTLLCRCEGKVVMFDLTQRLVLGEVHTPSVRHVVWSNDMESVALLSKHTIILASKKELVIQCTLHETTTRVKSGAWDDDNGVFIYTTLNHVKYCLPNGDSGVIRTLDVPIYYHQVNATEYMFKLALMRKRFDHVARMIKSSRISGQAMVAYLQQKGFPEVALHFVEEEGHERVRFNLAIESGNMSVAVASATKINEKDYWFRLGVEALRQGGNSSIVEFAYQQTRSIERLSFLYLITGNLEKLSKLMKKKDVMGQFQNALYLGDVKERVKILEKGGLLPLAYITASVHGLKDIAERLSIALGDDVPSLPQGKTHSLLMPPIPVVCGGDWPLLRVMKGIFEGGLESGNDDVEEGDWGDALDMVDVEEDGEGSGWGGLELLDTPFMTPSQGMDVSQIWSQESPLAAEQAAAGSFDTAMSLLHRQLGIKNFAPLKSMLLDLFSGSHSYLPAFSSSPVLTSLTANLQPPHLRLALLSAMGVCYKARNLATAYNFAKRLLETNPTESQAKTARQIVQAAERNMTDATELNYDFRNPFVICGSTYVPIYRGQENVSCPYCTARFVPSQEGNICGICDLAVIGADASGLLCSPSQVR
The following text describes a protein:
Function:
Required for initiation of chromosomal DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MFVTDFRKEFYETVHNQRVLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAYLEHKEQFSYFILINCGANVDLLDILQPDEDSIFFVCDTHRPVNVVNVYNDTQIKLLIKQEDDLEVPAYDDIFRDEAEDEDLSDSDGDGSEPSEKRTRLEEEIVERNRKRRQRREWEARRKDILFDYEQYEYYGTSSAMVMFDLAWMMSKDLNDMLWWAIVGLTDQWVHDKITQMKYVTDVGILQRHVSRHNHRNEAEENMLSVDCTRISFEYDLCLVLYQHWSLHESLYNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQSMDVSLKGNLREMIEESANKFGMKDMRVQTFSIQFGFKHKFLASDVVFATMSLMESPEKDGSGTDHFIQALDSLSRSNLDKLYLGLELAKKHLQATQQTIASCLCTNLVTSQGPFLYCSLMEGTPDVTLFSKPASLSLLSRHLLKSFVYSTKNRRCKLLPLVMAAPLSVEQGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRTLHNYFDLSVIELKAEDRSKFLDALVSLLS
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes.
Sequence:
MMRKTALLGLLTLGLASAGGAQPATPLSATAALRDGAGQVVGSARFVQQGAGVQVTVDVRGLTPGMHGMHVHEFGRCTPGVDPAVNKVVPFGAAGGHFDPSMSRNHDTPQTDNKHGHGGDTPMLSVGADGVGKASFTSTKISLTGENGILNRSLVIHANPDDYKTDPAGMSGARERCGVIVRDGLSVRDYALPGPVDHPEGVAYDAKKGLIYTGSAQNGTIYAINAQSGAVTKFQEGGAYGRQVALGLKVDPQGRLWIAGGAQGTVSILTPDGMTLAVLETPKSPRPYINDLVLAPDGNFYVTDSSRPVIFRVDKALKLTAWLDLAGTPIKYGPGVNLNGIAATPDGKYLLAVQLNTGELWRIDLKTKAVKKVMDGLVNGDGLLLDGRTLYVARNKDQVVAKVSLSADYGSGQLVAQEPLNGLRFPATLAKVGNDLVVTQAQLDRIGGTPETPFKLTRFAKF
The following text describes a protein:
Function:
Synthesizes sphingolipids through transfer of a phosphatidyl head group from a glycerophospholipid on to the primary hydroxyl of a ceramide in the lumen of the endoplasmic reticulum. Catalyzes the synthesis of ceramide phosphoethanolamines (CPEs) (such as N-acylsphing-4-enine 1-phosphoethanolamine) by transferring phosphoethanolamine head group, which is smaller and more hydrophilic than the phosphocholine (PC) headgroup transferred in the canonical sphingomyelin synthesis (SMS) reaction by SMS1 or SMS2, from a phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to a ceramide (such as N-acylsphing-4-enine). The larger PC prevents an efficient fit in the enzyme's catalytic pocket, leading to little or no SMS activity. In vitro, in the absence of ceramide, it has PLC activity with preference for phosphatidylinositol and phosphatidic acid, but also hydrolyzes phosphatidylethanolamine.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAGPNQLCIRRWTTKHVAVWLKDEGFFEYVDILCNKHRLDGITLLTLTEYDLRSPPLEIKVLGDIKRLMLSVRKLQKIHIDVLEEMGYNSDSPMGSMTPFISALQSTDWLCNGELSHDCDGPITDLNSDQYQYMNGKNKHSVRRLDPEYWKTILSCIYVFIVFGFTSFIMVIVHERVPDMQTYPPLPDIFLDSVPRIPWAFAMTEVCGMILCYIWLLVLLLHKHRSILLRRLCSLMGTVFLLRCFTMFVTSLSVPGQHLQCTGKIYGSVWEKLHRAFAIWSGFGMTLTGVHTCGDYMFSGHTVVLTMLNFFVTEYTPRSWNFLHTLSWVLNLFGIFFILAAHEHYSIDVFIAFYITTRLFLYYHTLANTRAYQQSRRARIWFPMFSFFECNVNGTVPNEYCWPFSKPAIMKRLIG
The following text describes a protein:
Function:
Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MLWYLLYPLRGTTEAPVLPPDHPLRTAFSRYGTWTARHVKTVLPLSVALVFCLLYPIFFLYTTDATNVTSGVSNLPHHVWTDAQPLSERAVAEPDVIMRSVWVHGSYMKALDREILLGALELQDTLLGPTTNFNPRRPHASRILPHDPTVDMTRDQRDAFHIVNGLTDQSWFFHSPLQYWGGSADNIAADSDIISTVNEKKTQSTSVNITLRHSFVFSGKRFEERRLVAADALVITLIHLKDSPLGRQWVRNAERLAAQVHDKWTVIPHDGKSMASQLYEFQFRPMSWPDWFLLTIAYSLTLFYLLLSLSKLRAVKSRFGLMATILAQIAASIGSSFTICAIFKIDLSRVPYYAYPLVVLAISMENSFRLINAVIMTSSSISISDRIGEAFGQTAYVAILNRLQNLAILLGLSRITFPGVAAFCTFAAVAIVFDFLYLATFFLAVLSVDVRQRELYELEKASLRKTNDVYEITLLDRIRRIRHGGATVSTRVAGTIVILGFILLAQSHYALESGSQWLNWIFTRSWRVAEPAFSKSSHLVDIHQARSPTSWLRLQDHETAREVINVVKPWAHSYVARVYEPLVFVAKGANRIPHSPEPMFLPAVYDFIHNEIPRFVVIMLMLVALLLLLTNYLLQGNDKQAGDPDHPENEPLLSVRSLSHGHDLDVVKMAVSPGHKLVSVGLDRNIQIWDVPLNSRTRVMSDSETPLENPFPVLAMAIDDDSKWLALLTWQRVLLWDTDEQQWGLSIEVELGGHKPEAMFFNYTNKTLDTPSLVVVRKNGTMFELDLEGTASKEFTICKTPFAMALPFVELTSANQVSQSLSILTLSRKSCIHIVRQQPGGWTSKEVKLTTGEAKDIHSIVPAPDLSMYLVCRSRSVDLVDLESSAVIQTFNTEPMEPRSLKLLLSSRGAPQHGLPPLSLCYISLETGDLVIQTFYRADEVDPMHYPKDYAPEAPNQPWNEEKEVKKRIEKPGRWEILPNGGIVGVRRVPVASLSSSRRRSFRAVSSGVGTGYGLRRRGAGSGGTAADSTDVTTPDIGMTVWEAWAFNNLESAKTKGIETQPLDQQADGEDAMYDNLWVSELGPMVRLGTASVAVGLGNVIKVISVGHEHFDKVVTRDRLTAENLRNQNYFRRRKTGSAQRARGGLGGGGAAAGI
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKRYKELTSKKFVKILQTISAITALSVPDLFTYGGLPVIYILYSILIAFTLVALSVYTLYFKVIYFYKNLLATVSILDSVTIASVTLTNVLSIFFAVIFRRRKIVSLVKNLQEIERVLNEKFQVSCEINEKSLLIVFGLLETFLFSYIAFDCVSQIRTHGFFLYSLSVVMHLNVFLVSITVSQVQLFSTCIKQYFSVVNEQLATTKVATIKMKFFLQTYDKLCDIVDLVSDSYGIQIACVTFIIIICLIESLNLLMKCALRVQTLGEVWPITLLIADTWNSIIYILFGIILSICCQQVSNEANNTSVLSYKILLNFPSRPKSQNDEINKSELLLLAEHLSQRRVKFSAAGLFDVDHTMLYMIFGSIAAYLVIVLQFK
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to benzaldehyde and acetophenone.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDNVAEMPEEKYVEVDDFLRLAVKFYNTLGIDPYETGRKRTIWFQIYFALNMFNMVFSFYAEVATLVDRLRDNENFLESCILLSYVSFVVMGLSKIGAVMKKKPKMTALVRQLETCFPSPSAKVQEEYAVKSWLKRCHIYTKGFGGLFMIMYFAHALIPLFIYFIQRVLLHYPDAKQIMPFYQLEPWEFRDSWLFYPSYFHQSSAGYTATCGSIAGDLMIFAVVLQVIMHYERLAKVLREFKIQAHNAPNGAKEDIRKLQSLVANHIDILRLTDLMNEVFGIPLLLNFIASALLVCLVGVQLTIALSPEYFCKQMLFLISVLLEVYLLCSFSQRLIDASENVGHAAYDMDWLGSDKRFKKILIFISMRSQKPVCLKATVVLDLSMPTMSIFLGMSYKFFCAVRTMYQ
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.
Subcellular Localization:
Nucleus.
Sequence:
MPEPRKEASNKNKLYKKSKKTQPILSEEDTQMTRKVRVIFHDPYATDSSSSEDESERTITRKAPRGKLVVREVGVPILGLVSHSKPLEFEASSQDSNCKTPTRRKRVLDTTLDDNALVVEAKIPVGVRRRKWGKWAAEIRHPLEKTRIWLGTYDTLEDAARAYDAKKLEFEALAVAAVAAATASSDKTYDISCSASTSHTSNSVASVPEESVSPSSHTTPSSVLELDTSASVSFFNSNHDSGNANKEGFDANFANLVIPDLCFLDDPLLSGSVGQELNLDEEPSDYLFVNDSRVILEDYCSIEDLSICGIEGNEPSELPDCDFSTDDFDFLQKSSPPQHFVPISFAVR
The following text describes a protein:
Function:
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
Subcellular Localization:
Cytoplasm.
Sequence:
MAMEDGFAAEKLFNQGFSYTYDDVIFLPHYIDFPTDSVQLATRLTRNISLSIPCVSSPMDTVTEAYMASAMASLGGIGIIHSNSPASQQAAMVHAAKARRVPILSNLVFKSPSDRIDSDDDFASSPFILVTESGTSKSKLLGYVSYADWTSQGNKEVKIYDYMVNSGASVPWNYDLGQLDAFLEENKKDFVPLLKDGEVVDVATKSEVERIKSYPKLGVGSVAADGSWLVGASIGTREHDKERLKLLVQAGINVVVLDSSQGNSSYQIDMIKYVKRTYPELDVIGGNVVTMAQAQNLIQAGVDGLRIGMGSGSICTTQEVCAVGRGQATAVYKVSLVASHSGVPVIADGGISNSGHIVKALVLGASTVMMGSFLAGSTEAPGAFETRNGQRVKKYRGMGSLEAMIKGSDARYLGDTATLKIAQGVVGAVADKGSVLKFIPYTMQAVKQGFQDLGASSVKSAHDLLSSKVLRLEVRSGAAQVEGGIHGLVSYEKRSF
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B (By similarity).
Sequence:
MATTEDDRLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLSRCGFRGSSYLGIPFNPSKNPGAAHPYDSGHIAMTYTGLSCLIILGDDLGRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSDNVHIAT
The following text describes a protein:
Function:
Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.
Subcellular Localization:
Nucleus.
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MPLKNYTKTTSKKEPKQLDIAASDQQIEQWSDQIHKLDKAIRSTIDNSRLFYDAWRCMVCIAPSVTASWISLYRQLPPEKQPAASVGTLVDWNKALERQRREVLLALQNFHVIVIAPCKEVKGYVKKAVEMIKRRDKKVKELEKIQKELLVVYELPDPETKKSKIKALQSQLVRVNGELDDLQKHLTLSFPTLIAKSRVFFGQLMKHFYCLQLQMFRKMHNIVRPWDCFQDDIPQTWLVEFSSVCQAAESISLIAVNNNRPPVELPKSGDVLSNREWEAGKIDAMNSLIAQNLHTSASQVSLSPMASTASSSVTNSPVDTHTPSTPIMSRPPSMKALSSGVESQDESVASSNFQVPIISNPLFKSPAPYSPTSVISNHSSTGKSLVISEWAYLASGSANVVFEYVGKNPYFQDKVIRLRRRGQVFTTEQVYEYYQNVIYPLFAGMESFLIEVFLQPVTRDFLLAAQNASGIYLNLNEQYCLVMKDLKDGIEMKPKWLTQSPAAPPDWVVCRTCALSRMRGRPVGFCPLQLDFNNWPKFLCCLQGFVSPDIAMRLFQSGILRKLRDLQEQYSRTDVALAMTLRDVTLYIGKDHITLLDLDPKDMNTKMSKWERDERNLIEGGWYYGRGMKSTDKACRSSIK
The following text describes a protein:
Function:
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells.
Domain:
The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2.
Sequence:
MGTEGKAGSKLLFLFTSMILGSLVQGKGSVYSPQTAVQVPENDSVKLPCIYSGFSSPRVEWKFVQGSTTALVCYNNQITVPYADRVTFSSSGITFSSVTRKDNGEYTCMVSEDGGQNYGEVSIHLTVLVPPSKPTVSIPSSVTIGNRAVLTCSEHDGSPPSEYSWFKDGVPMLTADAKKTRAFINSSYTIDPKSGDLVFDPVSAFDSGEYYCEAQNGYGTAMRSEAVRMEAVELNVGGIVAAVLVTLILLGLLIFGIWFAYSRGYFERTKKGTAPGKKVIYSQPSARSEGEFKQTSSFLV
The following text describes a protein:
Function:
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
Subcellular Localization:
Nucleus.
Sequence:
MPKKENLTSSDSDSENEKKLKAKLRKDQSRKRKSEPEVQNSGKRSNVPTPEVGGNSNEKIHLGKMKFIDVRTFKDKILIDIREHYQKDGEIKPGKKGISLSTEQWEKLKMSMEEVDSRIQQF
The following text describes a protein:
Function:
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Subcellular Localization:
Secreted.
Sequence:
MRRLMVLLLAISMNYADERGKPYQKDKVCQELQILGKDKFSSIALIMNSRKYSNATFEEIGHLVTAIVSLAETCCAKEAAADCYDKKANALSAQSCDPKSPFPKHPGVERCCVHKGLERKLCLADLKQPPKEFPTYTEPSNEKLCESFKENAQVFSSRFLYDYSSNYAQTPFLVVVNSTEKYLKMIIECCTKPRQTQCFLKQRLQIRPVHLLTVMSNRLCGRYNSYGEENFKIGASIRLSQKIPSAELKEVMPLVEQCGKILAKCCNTLTDDCMENELSVHVQQICKKFSSKEAKVAECCKKSSIEILLCLYSLPSAEPVQLPTLHWPSSDQLCKKGKNQEIIKYILELARRNTKMPILFINKLHDSFAELVNGCCFSQTPDVCLESKKSQLNEEMNRYISQATELCADYHKYPFLEFKEKLSKALSRKVPKLSTSQVEEMVEARSSLASTCCLINAPPVYCREMINKFLNNICLQESCLLQ
The following text describes a protein:
Function:
Inhibits CYCD2-1/CDKA-1 complex kinase activity without interaction with the complex.
Subcellular Localization:
Nucleus, nucleoplasm. Note=Distributed in a ponctuate pattern.
Sequence:
MGKYIKKSKVAGAVSVKDKSHPPALGFRTRAAAAKNLALHRLRSHSDEADSFNYLQLRSRRLVKLPLLTNTRKQQKQQLIPSVNQCQTKNPRASSGPAKKLEPDTTTEEACGDNERISRSDCNFGDKGFDLESENRSMISDSKSIQSEIEDFFASAEQQQQRFFIQKYNFDIVSDNPLPGRYEWVKVMP
The following text describes a protein:
Function:
Metallocarboxypeptidase that catalyzes the removing of polyglutamate side chains that are present on the gamma-carboxyl group of glutamate residues of tubulin in sensory cilia. Probably via the deglutamylation of tubulin, promotes microtubule stability required for axon regrowth after injury. Also regulates microtubule dynamics in uterine muscle cells.
Subcellular Localization:
Cytoplasm.
Sequence:
MGYVGNVSYPDTIPGQGNLVFEASFESGNLGRVDKVSCSEYDLFIRPDTLNNKYRVWFYFECKNASENQRAIFNIVNFSKQRTLFEMGIAAPVVKSNAQNSWARIPSRHIYYYRSSQHNDRWILSFAFIFESPDPVQFAYCIPYTYGQMQIWLNELESRKYPFFHRDLLVQTVQKRRVDLITIDATPDTFQGSKKMIFLTARVHPGESPSSHVMHGIIEFLVSKDDRAQKLRKVYCFKIIPMLNPDGVFLGNYRCSLMGHDLNRMWRTPSDWAHPSIYAVKNLLTQYDNNPQAQTVIYVDLHAHSQKPNCFLYGNVNMSAVEEKSTFRQLWLPHLLADLSEDYSLEFTQFNTDVEKAGTGRRTMGDLLSCLCYTLEVSFFSYRHTDSSGNGIQHCTPYLQYKYEALGEAFCRALLNFYEADCGLREIVLERPFKTFLPARAQKTLKKQARKVIQTVMMK
The following text describes a protein:
Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGDSQYSFSLTTFSPSGKLVQIEHALTAVGSGQTSLGIKAANGVVIATEKKLPSILVDETSVQKIQTLTPNIGVVYSGMGPDSRVLVRKSRKQAEQYYRLYKEPIPVTQLVRETAAVMQEFTQSGGVRPFGVSLLVAGYDDKGPQLYQVDPSGSYFSWKASAMGKNVSNAKTFLEKSQSEVAFMFTGEFLLAFKIDIQVSARYTEELELDDAVHTAILTLKEGTAEKTNIPWTEMTKEILNSDVYKELESIENPAIVYPDYYLNPFHAYDEGNLSWLAAAEADAATMSMVRRAIPNASSLDEANQIVRGNWLDAIEKHHQQYSADFSIRDILDIGCSVGVSTGYLADRFPSAKVTFHECPERAIRNIVKESFRLLRPGGTVAITDNSPKSKILQELPPVLFTLMKSTEPFLDEYYLTDLERVIKETGFANVQTVLTDPRHRTVTATVPY
The following text describes a protein:
Function:
May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway.
Sequence:
MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGVFTAVKVMNARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLHHPFVREIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTMRRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQALDSAPGPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLMPLQAQVRAPRLLQVQAQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQTPEQQQRHDQVPEQELEQNQEPEQPEVREQAAEPAQAETEAEEPESLRVNAQIFLPLLSQDHHVLLPLHLDTQVLIPVEGQTERSPQAQAWTLEPPQAIGSVQALIEGLSKDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPKRFRAKSSRRPEELELSDLEARRRRRQRRWEDIFNQHEEELRQVDKDKEEDESSDNDEVFHSIQAEVQMEPLQPHISNPKKIEVQERSPSVPNNQDHAHHVEFSSSVLQRSLLEQAQKPIDIRQRSSQNRQNWLAASESSSEEERPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVYLTNEWVGYNALSEIFRNDWLTPAPVVQPPEEDGDYVELYDAGADTDGDDDDESNDTYEDTYDHTNGNDDLDNQVDQANDVCKDHDDDNNKSVDDVNNSYYEAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYGSHRANRSHGGSAASEDNAATGDQEEHAANIGSERKGSGGDGDKAVIRTSEESGALGPNGEENCSETGGPGLKRAVSQDFEYLQEEPGGGNEASNAIDLGAALSAPDDESDNKDIPESSTQSDFSANHSSPSKGFGKSADANFASAILYAGFVEVPEESPKQPSEINVNPRYVSPSCKKPLIHMYEKEFTSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGRKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSIHLYAWAPKSFDESTAIKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHIIDAESEVMSDVTLPNNNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNRHSRVYFMTLGKLEELQSNYGV
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Subcellular Localization:
Cytoplasm.
Sequence:
APPGARRRPLALFSRPQRHRPTQSCRSLSLDNRASLLEVKEAAEPWHPVSGDSESEEEEVEEVESEQGSDSDDDGGRGGAGRGAQNRYLKNQEDDSDESDTGHRVIRSLRDKRNEEMRSIVDQMRNAMKINDWVSLQESFEKLNKHLEKVVRVNESTEVPKMYIKALVLLEDFLAEALANKEAKKKMSSSNSKAFNAMRQKLKKNNKQYEEQIQKCREHPESFEDEAADDKDTDDDDVDESDAEIEDPDKIAMSESEEEQDEEDDDKDGWEQKRSKKDKLMDKQFLKDPSEITWDIVDKKLKEIVASRGKKGTGRIERVEQLTFLTRVAKTPAQKLEILFHVISAQFDVNPSLLGHMPVNVWKKCVNNMLLVLDILQQYPNIVVDTSFEPDENETQKGADYNGTIHVVGDLVAFLERLDSEFLKTLQCTDPYTKDYVQRLREEPLFLVVAQNVQDYLERVGNFKAAAKVALRRVELVYYKPQEVYDAMRKLAEQPEDCVDDDDAEAGDEHKAVDDNRGPSPFVVIPEAVHRKPTFPESGRTLMDGLMFLIYKYGDERTKARAMLCDIYHHAISDEFSVARDLLLMSHLQDGIQLMDISSQILFNRVMAQLGLCAFRAGLINEAHGCLTELYSTGRVKELLAQGVQQSRYHEKTPEQERLERRRQMPYHMHINLELLEATHLICAMLIEVPNMAASTYDKRRPMSKTFRRLLEVSERQTFVGPPENVRDHVMAATRALNKGDHQKAFSVINSLEIWKLLRNREHVLEMLKLKIKEEALRTYLFSYSSSYESLSLNQLTTMFDLSEQHAHSIVSKMMMHEELHASWDQPTKCIVFHSVDQTRLQGLLFQMADKLSVLVEINERAYEARTGGALEGVPPRRRGEGQDNMGKWQDNFVSSQGRQGGGNRFGYSSRGAVSGQSGGGHQRDRGNQGYRGGYGGVSRFQDARGRNQSNPSGRGGDGGARMVNLNRVGRV
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MLSFSKKGGPGKEGQSFAPLFVSCSSMWNSSDKAEYAPSKKVLTGVESALEHHSDIKKSECQFQDQDSTSTLSTGQSNHVEAAMGKSNTVLQNVAVHPGWGGTYEVQAESGTNASRSGESDTNTLPQPQVNHNHPMACVSYPFADTYFGRLVTAYGSNAIIYPQMVGVTSTRVALPLECTESLPIYVNAKQYSAILKRRQVRAKLEAQNKLVKDRKPYLHESRHRHAMKRARGSGGRFLNTKNMQESKPSSPMHDRNIFKRQAGGNLSSSMVQHSESGSWGTSTQSGSDVTSIFSGDNMFQQPEFRVSGFPFHIQEAEDFLHVGT
The following text describes a protein:
Function:
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similarity).
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MSKKKEASKISPVLFLDPGGQSMRFYVRPGPTKMQLHPLITSGGGNLCRNQEPGAILLIDPTDATNVTQNTGQKYISTKYILDCVEQNQQLDPNDYAIIIGPSVQTRMALRNQGSGRLGYSSEEDAAILKFIEKRQQDAKGNLVWKEMEKRHVTEHSWQSMKDRFLKHLQQKLADKPTKKSPIKRKPLSFTQSPLRKKKVVEISEDESVQKGDCPEAPMATETGSINPPASPERASSPPEEPQAAGQPSQASSNDSQDETCVLVIETPESENPRLDEDAPDASNEHSSLKKKRRKTCKTSTTDSRSSRLEEDPVGQDIPDESNAQSSPKKKRQKACKTSTTDSRSSRLEENPDRRDIPDESTEQSSPNKSQMTSKISTSDSGNPIGDQGCDNPHGCNANSSPSKTRQTNSEASTPDSKKLGILAKAAKEFEDSDVMDDSEECENPCEVPIAEPSDAQESSATPATLVREPESQAEHHEETQPDSPMSEEERPGPSSAVVPPSLNSSTSCSHIRETPEETLSRDLLEVKEQVINLMRETKKDLVEVTKALLKASGDLKRAQVFLLNGYDHETHGPLWTRLDDETLLAADPYELEQLQSKFGEEEVTRRKSFLATDVK