lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively. PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MKGKEECRVLSIQSHVVRGYVGNRAAAFPLQVLGFEIDTVNSVQFSNHTGYDHWKGQVLNSDELHELYEGLKLNNVNHYDYVLTGYTRDKSFLAMVVDIVQELKQQNSNLVYVCDPVMGDKWSGEGYMYVPEDLFPVYKEKVVPVADIITPNQFEAELLTGRKIHSEKEAIEVMDMLHNMGPETVVITSSDLQAPSGDDYLIALGSHRKKTPDGTTVTQRIRMESPKVDAVFVGTGDLFAAMLLAWTHKHPDNLKVACEKTVSAMQHVLQRTIKSAKALAGKGNKPNSAQLELRMVQSKKDIENPEIIIRATEL
The following text describes a protein:
Function:
Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA (By similarity).
Subcellular Localization:
Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MQTMLGKPALQYFGKLSRYLYKNGEPINIWVYSRNSSFSVIPKNGLLSPKITQRFYQNSSIQYQKDKNIYEPKENLEEKELSEGFLDESRLEIPEAGHNWEKSFFGLSSQPFSKEICDLLTAPLEVDDIEIKPDGILYLPEIKYRRILNKAFGPGGWGLAPRGNTNVTSKSVSREYALVCHGRLVSVARGEQTYFDPEGIATASEGCKSNALMRCCKDLGVASELWDPRYIRVFKRENCVEVFVENVLTKKRRKLWRRKEDKFSYPYKEV
The following text describes a protein:
Function:
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Cytoplasm.
Sequence:
MLQNGKKFDSSRDRNKPFRFKIGRQEVIKGFEEGAAQMSLGQRAKLTCTPDVAYGPTGHPGVIPPNATLIFDVELLRIE
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
Sequence:
MLRDPTTTIHAEDLQAGSSYDIPKLTQQTYGQIRAADEIIDEGHFIGKALGEGMNGYRPIVELMNTNFGIFGMAELSSAGNTFATTGGQFDMPMTIVGAGGTAPNQALGAEHSQPFHAYVMGIPGLKICTAASPDAAYGITKSMIRDNGPCFLFAPVKMMKEAKGTLDLDVCAPLNKAALLHEASAESVASGNAVTVLTYLHGVKEAQLVIDEITEEGFDIDLIELRSLKPLDMDTIRKSLERTNKCAILDESTQSGGVGATVSARISEDLFDLLDAPVKRLCMDDAPVPYASTMEVAVVKRGSDLVQGVFDLCTKQY
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
MHSVSKLPLGRFARCVITHPNLTRQPAFFVPCHNTANDVTATNIEAYNEPGFRDTPTKQLVRAAVVLRLSSFDFLVKHADTLFRLGNGVLGKTLFGKVMSATFYGQFCPGSKYEDVKKAAVAMQEAGVTPFFSIPAEEPITQLGDVEKWYADNTQTIIDCIDMTSKVNINGSPKLCHIKLTAFMDQALCKVLSDAIIANNGDDNAILESIKSFDKKPVHLDFLSDAENQHLTESLLRYDRICAHAAKQDVSVYIDAEYISFNPAIYLTCKAMMLRHNKTKPVVQITIQAYLKKAKMEAEKFIKCCQNSDIFFGAKIVRGAYMVTEQQRALDQGYEDPICDGLDATHANYNGIVKNLLRAISRKEKVHLMVASHNEDSVTHVVRRMKKLGIEPNEGKVVFAQLYGLSDHVSNWLGENGYLIYKSTPLGTIEDTMPYLYRRAQENNSITKGDKRDRALINIELSKRLRQFVFFWRKDEYHTLQ
The following text describes a protein:
Function:
[Exonuclease V]: Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity; [Isoform 2]: Plays a redundant role with the flap endonuclease FEN1/rad2 for the maintenance of mitochondrial DNA.
Subcellular Localization:
[Isoform 1]: Cytoplasm. Nucleus; [Isoform 2]: Mitochondrion.
Sequence:
MEEYEDFEMEDLSELVSYMDYLETQRLTISQLDYSLSIPPQLLVSREISKLEDEVCEMLKESSLFQLFRKHKGYLNVTDLVLPLWCEVQHEYYLLRRIKKKTPKMERGIKLHQILEYETSPPSERRVLDRTSKEEPWALRLLRQLEGIMLLQKNGITREFPIWGYYKESSIFGIIDEISLNNPSKSNFNSDIRNYFNFKMYDLSFVDNKTRFSSRKPGASQILSSKVQLMYYVHLFLNYFPSLGEKQQSIFRDISPTYSNRLHSQSHWWNMFLSQLSLDGTKDLGPKFLEQSILSIPDIPEDVFAGHNSLNGLYALVFASAKKLHLRLTDDNLTIAYRNDKTGEVVYKDKFSFSNKLLEASYTKAYQFWHNLREPEGVPAEEVYKCRSCEFQKECWWLKKKQYYPLSSP
The following text describes a protein:
Function:
Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position.
Subcellular Localization:
Cytoplasm.
Sequence:
MITTNKALFLDRDGIINIDRGYVSQKEDFEFQKGIFELLKHTKTLGYKLLLITNQSGINRGYYTLKDFEQLTEYLQESLLKELGFNLDGIYFCRHAPEENCACRKPKPSLILQAAKEHQICLERSFMIGDKESDMLAGLNAKVKNNLLLTQNPLKTPHSWIQCKNLKEMIDWIK
The following text describes a protein:
Function:
Probable carboxypeptidase.
Subcellular Localization:
Secreted.
Sequence:
MGAHQWIAMAVLCATFFQICRAVDSSADDKLLSLPGQPRVSFQQYAGYVTVDENQDRALFYYFVEAETDPASKPLVLWLNGGPGCSSVGAGAFSEHGPFRPSGGGSLVRNDYSWNKEANMLYLESPAGVGFSYSANQSFYDLVNDTITVQDNFVFLQNWFLKFPEYKNRDLFITGESYAGHYVPQLADLIVKSGLKFNLKGIALGNPLLEFSTDFNSEGDFYWSHGLISNPTYELLSAVCNTSQLWRERIGNSLSASCSKVNDQLNAEIPDAIDKYDVTANVCLSFGASLLGVQNNPLTPRFRLFSSAESLQEALSQQKAQENIDPCVQEETFVYLNRKDVQESFHAKLVGTPKWTFCSGVVNYDLRNLEIPTIDVVGSLVNSGVRVLVYSGDQDSVIPFTGSRTLVEGLAKKLGLNATVPYTPWFEDKQVGGWTQVYGNILTFSTIRGGSHMAPFSSPGRSLALFAAFLSGKPLV
The following text describes a protein:
Function:
Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA.
Sequence:
MGYRLSKIYTRTGDAGETGLADGRRVTKDHPRVDAMGEVDTLNSHIGLLLAELAEQQAQWPGLTEVIEVLAPCQHRLFDLGGELAMPDYQALQAPEIERLEAAIDRWNEEVGPLENFILPGGSRLIAQAHVCRSLARSAERRCQHLNAVEPIRGVGLAYVNRLSDLLFVAARLIAKRQGIVEVLWQAAAKEPQS
The following text describes a protein:
Function:
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
Sequence:
MSGPLTERRQMILKLVIQEFVDTATPVASETLVRKYRLPVSSATVRNDMAALEELGFLTHPHTSGGRIPTDAGYRFFVENLMERTTLSPAEQRMIRHQFYQVRGELDQWVQLACAVLARTAHNASVATAPRAEQLRFKSLELIAIHETMALAVIVFHGGIVKQQTLPIEPGRTPEDLRRAAGLVSDLLADATLSRAEELAAIATFNGVPLSEFERTLVDLVVRAMSVFEEQAQEQIYSDGILEMLSQPEFLPASGRDDAERAIERLRRTLEILKSGRGLSPLIPQALASGGVQVIIGGEHSEDTMRDYSVILARYGVEGALVGVLGVIGPTRMAYPRSISTVRYIASLMTNLLADLYHVNTRPSDIEPAAEL
The following text describes a protein:
Function:
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV).
Miscellaneous:
MISCELLANEOUS: Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form; MISCELLANEOUS: [Isoform 3]: Interacts with BCL2L1/BCLX.
Subcellular Localization:
Mitochondrion. Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side; [Isoform 1]: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side; [Isoform 3]: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side.
Sequence:
MASCAEPSEPSAPLPAGVPPLEDFEVLDGVEDAEGEEEEEEEEEEEDDLSELPPLEDMGQPPAEEAEQPGALAREFLAAMEPEPAPAPAPEEWLDILGNGLLRKKTLVPGPPGSSRPVKGQVVTVHLQTSLENGTRVQEEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYGPQGRSPYIPPHAALCLEVTLKTAVDGPDLEMLTGQERVALANRKRECGNAHYQRADFVLAANSYDLAIKAITSSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQRSTETALYRKMLGNPSRLPAKCPGKGAWSIPWKWLFGATAVALGGVALSVVIAARN
The following text describes a protein:
Function:
Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MAGEEINEDYPVEIHEYLSAFENSIGAVDETLKTMMSVSRNELLQKLDPLEQAKVDLVSAYTLNSMFWVYLATQGVNPKEHPVKQELERIRVYMNRVKEITDKKKAGKLDRGAASRFVKNALWKPKPRNASKVANKGKSKS
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Sequence:
MGAGAGGLSLRGARLSPEERANSSKSRAIDRALSKDHTDDLNRFKILLLGTAESGKSTIFRQMRVLHLDGYAKEDALEYLSIIHSNCMEALTQLVEACSAFGILHDITVQEDVDRFEGFKKKLRDPEGLVIPVVIGRCMDRVWQSSSMQMCYETRRFRFALLDSAKFMDNIVRLTEDNYVPTIQDIVHCRISTTGINEIAFNHKKMDFKMVDVGGQRSERRKWIHCFDNVDMILFIVSMSDYDQLDPEDHKYNRMKQSYEIFKTIVHCDLFRHASIVLFLNKYDVFVEKLKTSPLRRSFKSYDGDNSEESARDFIKKLFRRCITDRHKFFVFETTATDTGNIDLVFGSAVAHIVNENLRSAGLHE
The following text describes a protein:
Function:
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MLLPDLHPYTILLSIFLVLVAKQLVATIGKSTIQEFVWLVYLKVSSNQSIKTYNSKQHELHETNRQKRAISAQDEYAKWTKLNRQADKLSAELQKLNQEIQQQKSSIDKASNALILVLTTLPIWIARVFYRKTHLFYIRQGIFPKYVEWVLALPFLPNGAVGLTIWMFAVNSVVSNFSFLVSFPFAKRVSKPVRDTKVE
The following text describes a protein:
Function:
Acts as a negative regulator of autophagy.
Subcellular Localization:
Nucleus. Cytoplasm.
Domain:
The PHD-type zinc-finger domain is required for negative regulation of autophagy.
Sequence:
MLGIMDHHQDTVRKCKSEALPPERRKRTVEDFNKFCSFVLTYAGYIPPQKEESSWSPSSSPCTHDLSELSGEGSVKDSWTDSHSDLNNIHNLVYKAETDSSSSREFSHLPSDNSLDKMTLKDSLNHVHSKAERKKVKKLDRLSLGGPRKSISEARAHKQSKAALKKIKTSIKAERHFTSSSPLNEGFEKEELTEQAIHMHEAGLKLESNQETDLSSCETDTLVTDEDIMVESGDDSWDLITCYCGKPFAGRPMIECEECSIWVHLSCAKIKKSNVPDIFYCYRCLDSRGSTVKRDH
The following text describes a protein:
Function:
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MNPDNCALAAQGLVSLSYIRQGEQGLARRQRLVKSLLSSRRLPEAGWDEATIEMFIRDCSAMDSNNFLDNVGVGEREGRLACPLVARRHYGLAHGIGRSGDVAAEQPKAAGSSLLAALTAALAGDALRIAGMTGVGPVTVLPLATGMSLTLTLLALRGERRAELAREDAAAAAAAEAAGAAAAAVAEVPAAEAPIAAAESAGTQAATSAANGVAAGSGAQADGGAGLPAADPDVVVWSRVDQKTCLKAVTAAGLTPHVVQLRRQGDQLVTDMEALAAALQHYGRRRVLAVVTTTSCFAPRAPDDVVGVARLCAGAGVPHVVNNAYGVQARDTCRLLTSAWNKGRVDAVVQSTDKNFMVPVGGSLVAAPAGRPGLVAAVNGTYPGRAAVAAHLDLLMTLLHWGAAGWRKVLHQREEVLPYLRQQLTALAARHGERLLDTPGNPISTALTLDTLVAASAAAKQRAAEATAAAAAAAVAAAAPVAVEAGQEGMAGAASGLNGVAGKKAGTSAAAPDVTFFGSMLWQRCVSGTRVVAPGKTQSVGGVAFRNYGSHVEEPFPHTYMTAAAALGTTREDVDELVVRLDKCFTEFKKKCGGV
The following text describes a protein:
Function:
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MNKLFLTAAVLMLGACGFHLKGADGISPPLTYRSWHIEGGQALRFPLETALYQASGRVDDAAGAQMTLRIDSVSQNKETYTVTRAAVINEYLLILTVEAQVLKRGEPVGKPMTVSVRRVLAYADNEILGKQEEEAALWAEMRQDAAEQIVRRLTFLKAE
The following text describes a protein:
Function:
RNA-binding protein involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MADPDKLRSDAGEKHGEVGNGSKKREAAAGPVSFGFSKTVSKFRVQSSAEKVEEKDYLTGVEGKELKSTRPAEKPKELVIPLIHKNRWYKGEGASRTASETCPQPPREEDAVESQAVKELIEESQRQQELWKNGGAADLNLSIPLLMQNKAPEGYEDGDKIQVDLRPESDEILWRGEHASGQEGAEIESSPHCLRSPYCSTEADYDNVPVEAYGMAMLKGMGWKQGQGIGRTFKQDVKPIEHQLRPKGLGLGADRSAISDLDPSRPTRPPKPGEERADEEPRELVTGACVLVETGPHKDLYGKVEGVDPDNARVMVKLAIGGKTVTISQYSLHLVGRKEYDKYSRDLSRLGKAHKEKERAEEAARRSNGQDGAEGRGTDRESREPEARAGREHDRGKDREKEQRKRKHRDSSRDREKPHPPPPGALSWLQRDLRVRFIDKKFKEGKYYNSKMIIEDVLTPESCVCRTDEGRLLEDVKQTMLETIVPKSESDSIMVVLGKHRGQVGHILQRDKEKCRALVQLERYEEQVFKLDYDAICHYVGGTDV
The following text describes a protein:
Function:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MASNQELVQIATNFLLNAPPCEFMEVVSDVRALLPSESLLNASAGSTFREYNTSQMVSVQTSKGSALITKEGEISNNEYLDPKNKQVITYDHIKQEVTGERSASGEIEQDIEQYRAAFDEEATKYCNEYYPNGVSAVYGTKVSEGIKITVCISTCIYKPNAFYSGRWRSVWTCTFKPGSGNVTSNGKVQVNVHYFEDGNVQLNTVTQKQTTSPSADAQSTAVNAFKAIGKAELNLHTALDNNYSTMGDTTFKALRRALPINRTKINWQKVKNFKIANELNK
The following text describes a protein:
Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAESPTEEAATATAGAGAAGPGSSGVAGVVGVSGSGGGFGPPFLPDVWAAAAAAGGAGGPGSGLAPLPGLPPSAAAHGAALLSHWDPTLSSDWDGERTAPQCLLRIKRDIMSIYKEPPPGMFVVPDTVDMTKIHALITGPFDTPYEGGFFLFVFRCPPDYPIHPPRVKLMTTGNNTVRFNPNFYRNGKVCLSILGTWTGPAWSPAQSISSVLISIQSLMTENPYHNEPGFEQERHPGDSKNYNECIRHETIRVAVCDMMEGKCPCPEPLRGVMEKSFLEYYDFYEVACKDRLHLQGQTMQDPFGEKRGHFDYQSLLMRLGLIRQKVLERLHNENAEMDSDSSSSGTETDLHGSLRV
The following text describes a protein:
Function:
Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum. Golgi apparatus. Mitochondrion.
Sequence:
MCLCVCVSDGSDLRMVLLGVTGSGRSSAGNTLLGRSAFWTDTSSVSVTSRCQRAGGVVEGRSLQVIDTPGFFHTCLSPEEVRVELSRSVDLLAPGPHVFVLVLRPCRLTPEQCASLHCTRATFGPHALTHTIVLLTCGDALGSKPEEDFLKESSELWEFVSECAGGFHVFDNTKAHEDRSQVSELLQKVDRLVERNKGSHYTADRLLQAQADILQIQQRILGEGAGPVAEGRSQDAEEEESRRRAERVFWYELLTAVGRGAVEGSGVMEKGKGKGKKVKAVQRAAAIAATPLSINTAAKVVGGAMREGAKILDKHKKTFLR
The following text describes a protein:
Function:
NADPH-dependent pterin aldehyde reductase involved in pterin aldehyde salvage during folate turnover. Catalyzes the reduction of diverse aromatic and aliphatic aldehydes (e.g. acetaldehyde, n-propanal, 1-naphthaldehyde, benzaldehyde, cinnamaldehyde, n-butanal, n-hexanal, n-pentanal, 2-naphthaldehyde, n-octanal, n-nonanal and n-heptanal), in addition to the conversion of pterin-6-aldehyde (PtCHO) to 6-hydroxymethylpterin (PtCH(2)OH), and the conversion of dihydropterin-6-aldehyde (H(2)PtCHO) to 6-hydroxymethyldihydropterin (H(2)PtCH(2)OH). Cannot reduce the pterin ring.
Subcellular Localization:
Cytoplasm.
Sequence:
MTMATPFSGAANSIVAARTVLITGVSKGLGRALALELAKRGHTVIGCARSQEKLTALQSELSSSTNHLLLTADVKSNSSVEEMAHTIVEKKGVPDIIVNNAGTINKNSKIWEVSAEDFDNVMDTNVKGVANVLRHFIPLMLPRKQGIIVNMSSGWGRSGAALVAPYCASKWAIEGLSRAVAKEVVEGMAVVALNPGVINTELLTSCFGNSASLYQAPDAWAVKAATMILNLTAGDNGGSLTV
The following text describes a protein:
Function:
Negatively regulates the high-osmolarity glycerol (HOG) pathway through its negative regulation of the HOG1 kinase activity. Mediates the binding between the PTC1 phosphatase and the PBS2 MAP/ERK kinase (MEK). With PTC1, regulates endoplasmic reticulum inheritance through the cell wall integrity (CWI) MAPK pathway by modulating the MAPK, SLT2.
Miscellaneous:
MISCELLANEOUS: Present with 521 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MATMETTTQKDTNILKSGLKKTIGVLNEAVLQNGREVEAVQAGNSDTMEDTETTTIGYISIKDYAYADSNPLHYGYFDGDNEEDEMVSDSSNGEDTYNKRQSITLPDDYIVNQRAVALYDFEPENDNELRLAEGDIVFISYKHGQGWLVAENESGSKTGLVPEEFVSYIQPEDGENEVENKARPFYLTHLITQSVSPKNNIDNTNEDEYDDNDEWEDIDDVAEVEADMKTKLDISD
The following text describes a protein:
Function:
RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the piwil2 slicing-triggered loading of piwil4 piRNAs. In the PET complex, exd1 probably acts as an RNA adapter. Exd1 is an inactive exonuclease.
Subcellular Localization:
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Domain:
The 3'-5' exonuclease domain lacks the conserved Asp-Glu-Asp-Asp (DEDD) residues that coordinates divalent ions essential for exonuclease activity.
Sequence:
MNNRLNTTSSSEESRFLEEMKRKRVNITLSDTEISGVIQKITQKKTLILEDVSEVRSGRRFPGAKLIFGKEIVKVEFPLSAGQASVFSNEKHKSEFQTFKKKMTLDGEEDGVSYVLIDELHEKFGPAVMHIQEQDVIGIGADVYGQSGQERLCWLQVATKKVVYLFDILLLGGPAFKNGLSMILENTHILKVLHDCRCITRCLRTEFRVQLTNVFDTQVAELLLFFNESGGFLPDRPASLPELLQLHLRLTTAEIQPLCSKQQQSRECVQLWYVRPCPPDLLSLMCSSVQHLLSLRLLLLDALLADYTVLVDSFMSSSHCPPLHFQQDECAVPPELQELMCVRQQRMDWASQCYSQTDSGLLQRSSFKASPHTPADAQ
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMRRVKRTVAARVTDPVVGVARSAREYRSRTGDTAVAVQAVICGSLGAAFVAFLVGSQWTVFPAGVFLATTVVGWRREQAATGKAVTFLMTVGTVGVLALIVAFLLVRSVPAVEHMGVGLLGRTADPLWAARDGGVYSLAPMLVGTAITTCIATVIATPVGIAGAVFISEIAPPRVRDVVKPGIELMAGIPSITYGFIGLTVLNQYFYAEFRTPTIGSYLAAGAMIGVMALPTVVTISEDALAAVPESVKSGALAMGSTPWQTTKSVTLPAGLSGVSAGVLLGVGRAMGETMAATVMLTHTKGFPSPVFDVFSQYGETLTTVIAFEGGNASGVHMSALFAGGVVLFVTVMALSVGSQYVEWRMHRKLGGET
The following text describes a protein:
Function:
Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for activity and assembly of cytochrome c oxidase.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAFRQTLSIRSRLFARRNQPVYHIIPRESDHERDSFCQETSQRSYHSFLHQRSVNNSDFSKVSGGSLHLPLAPTSGFAFYRYMSSAPGVGSEKIGVMSDIAEVITDSTLQDVPAQAAAAVSEVTLAAADSFFPIAALQQCIDMVHTFTGFEWWASIVVATILIRSSTVPLLIKQMKDTTKLALMRPRLESIREEMQNKGMDSVTMAEGQKKMKNLFKEYGVTPFTPMKGMFIQGPLFICFFLAIRNMAEKVPSFQTGGALWFTDLTTPDSLYILPVITGLTFLITVECNAQEGMEGNPMAGTVKTVCRVFALLTVPMTMSFPQAIFCYWITSNLFSLMYGLVIKRPQVKKMLRIPDLPPPPPGQQPSFDLFSALKKMKAMTQDHTQNQIEPPSPVNPRLSSTSLSPVSKRLKALESQVKGRKKNSSKKK
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
Sequence:
MSTCINPSLIRQYLYCPAAAYYIMTGAAEPPTERMRAGKEVQREAVEAVAKALGAEKIEHSPRLEGGGLCGVVDAVLWLRGRPAPLEVKLAKPPRKIPVHHKAQAAAYAVAAQHHYGKAVASAYIYYTETGEVKYIALTRDLVELVKHTAQQIRKIQNGWTPTPAYHPAKCPSCWYRKYCGFTSPHVEKI
The following text describes a protein:
Function:
Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shows a nuclear localization in the presence of PPARGC1A.
Sequence:
MENFQYSVQLSDQDWAEFSATADECGLLQAGLASGDELLSSDIDQGDSSGSSPPRAPPLPTGQLAAGGRSRRGCEEEDVATQQPVSRSQGEPVLALGTGQQTPSTSARAEAPPSLGPGASPPSQFSSCPGPASSGDQMQRLLQGPAPRPPGEPPGSPKSPGHSTGSQRPPDSPGAPPRSPSRKKRRAVGAKGGGHTGASASAQTGSPLLPAASPETAKLMAKAGQEELGPGPAGAPEPGPRSPVQEDRPGPGLGLSTPVPVTEQGTDQIRTPRRAKLHTVSTTVWEALPDVSRAKSDMAVSTPASEPQPDRDMAVSTPASEPQSDRDMAVSTPASEPQPDTDMAVSTPASEPQPDRDMAVSIPASKPQSDTAVSTPASEPQSSVALSTPISKPQLDTDVAVSTPASKHGLDVALPTAGPVAKLEVASSPPVSEAVPRMTESSGLVSTPVPRADAAGLAWPPTRRAGPDVVEMEAVVSEPSAGAPGCCSGAPALGLTQVPRKKKVRFSVAGPSPNKPGSGQASARPSAPQTATGAHGGPGAWEAVAVGPRPHQPRILKHLPRPPPSAVTRVGPGSSFAVTLPEAYEFFFCDTIEENEEAEAAAAGQDPAGVQWPDMCEFFFPDVGAQRSRRRGSPEPLPRADPVPAPIPGDPVPISIPEVYEHFFFGEDRLEGVLGPAVPLPLQALEPPRSASEGAGPGTPLKPAVVERLHLALRRAGELRGPVPSFAFSQNDMCLVFVAFATWAVRTSDPHTPDAWKTALLANVGTISAIRYFRRQVGQGRRSHSPSPSS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Gene prediction based on partial EST data; MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Nucleus.
Sequence:
MAEAAPARDPETDKHTEDQSPSTPLPQPAAEKNSYLYSTEITLWTVVAAIQALEKKVDSCLTRLLTLEGRTGTAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEAPKVPVTFDDVAVYFSELEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPDILTRIERGEEPCLDRWGQEKGNEVEVGRPRMMGTGLPPYPEHLTSPLSPAQEELKEGQAPKQQQDSEARVAPAGPEAGGGVAIKTEAQSEDEMTPERLFLGVSRGQTECRIPRGPRNRPGGPSRHQAQGMPRVRAGEPRPPGASGETPRVLSRRRQRAFPCPDCGQSFRLKINLTIHQRTHVEEGRQEAPGRSPTSCGDSQAMLEPGEVVVPGPVIRWLPEEPEGRRSVAGGRALVGRRPAASKMYHCSECLRFFQQRKSLLLHQRLHTGNGQGWPACPYCGKAFRRPSDLFRHQRIHTGERPYQCPQCGRTFNRNHHLAVHMQTHARGQVGPHFPAAPARHGSLPLPWPSRKEEG
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MWDVVLIFSKRFPDCWTFLNAQKIVLNRLGHFLRSGCFGSQQISYPALLVFLETVPHNVVRAEQFFLDLFHNLWAGRKPSVSSIEDRIAFFRAFKECFLWAIQNASRFSDEVSSVHCCQSALVENILVKLLWEDFLLVFSPKVQSGTLTGISTESPEDQSLDVRKKIMERPPLRYPESYPQDLGKCIVEILSGIFQIEHDLLSSFSVAFCESFRGICQHSENGGQVESVERLIQFLLLLEHQAVRKSEYWPLDYIVGPTLAESFSSIESLDSPDGIRFLSAAISIFGPNKMVKVLLVPDKGSSSLLPFEEQSRKLELEHFMYIFEKRLVPWCLRGSGSCSAARLDLLLALLDDECLSEQWSLTLSHTIKLRSDGPEHAAVLCPLLQKARDKITNRQLAESKLHINSYVERWRHDLLDSLAVAVASSCPPNRIQEADFLRFALGGSSKDDQISLLSRDSCVLVFKALLEKLVYFILGSSFKWVRDAGSTLASGIGDLMIGGDRHNDQIDMANSALEVLLGSFYCLMTLNEDELVSNILAAVFILQWESRMGESLYDESDDKSLNLKARFEVGKSLHSFLRKINGHFCQDLGIHCRKKSSTVLVQSIRFAILEEHDLDANKVTSLCCWWILEVIEFFCLGQYEEQILLEQLLKKSDQWPVWISVDFDSRFGENVLTGSNISGGYKFASLVDKLISKRGVDRVFCRNISHVSSLSEETLEEVTHRAWLAAEMLCTWEWPGGSAITTFLPLLSAYAKSEAQPPKEGLLDSVFDILLDAALVQGGSRAHSFPNFYGTTADEVKNIKEPFVRALLSLVMTLFNDDVWKYDKARTLFQVLINKLLIGDTVSINGLQILPLIMRILIQPLCGSHKNFTDLESLALEDDEVQETIIGWLQRILSFPPLFTWQRDNDMEEWFQLVASCYPIGATDRSNVPKPERKISLREKTLLLDFFRKQRVGIDLSNASNHLQMLLSKLIVFSVGYCADDFNGEDWDFVLSMTRYWIQSAVVMMEDVVENINDLITDDSCSDKLDHSIIKKLEQIVLIKDHNRLDTAKSALLAYSSFSCFQLEKVADDQDPSRTEKQESIKNRITEGILRIFLCAGLAEAIASIHSPEAASVVASSLLDNLYFWETVARGVNESSPLARERAVRSVELWGMSKGSISSLYAILFSPKPAPSLQFAAYRMLSSEPVSHLAIGEETMHILDGEQDSSNIDFLSEQNVHMKEEISSMIEKSRQMFEMDLLAEERVHILLAWSLLLSHIWSLPTSPARERLVQYIHNSVDPVIIDCLFQHILDVAMPSNQKKKDAEFPAVVYEAATEAITSGRLLSSVESLWPIEPLTMASLAGAIFGMMLHLLPAYVREWFGYLRDRSTIEYFTKTWCSPPLISNELTQIKKASFIDENFSIRMSKAANEVVATYTKEETGFDLVIRFPASYPLQQVDVDCPRSKGISEDKQRKWLLSMMSFVRNQNGALAEAIRIWKRNIDKKFEGVEECPICYSIIHTENHSLPSKACKVCKHKFHSKCIFKWFNTSQKSNCPLCQSTFL
The following text describes a protein:
Function:
Transcription factor essential for the completion of meiosis in oocytes. Grauzone binds to the promoter region of cort via the zf-AD domain and activates cort expression in ovaries.
Subcellular Localization:
Nucleus.
Domain:
The N-terminal zf-AD is an atypical treble-clef like zinc binding domain which enables dimerization, and appears not to have any DNA-binding ability. DNA binding is achieved through the zinc fingers at the C-terminus.
Sequence:
MDICRLCLRGVSGAQMCLQIFDVDSGESKVAEVLRQHFWFEVLPNDEISKVICNVCWTQVSEFHQFYVSIQEAQVIYATTSKFKQDPEMVNTSWPEEVLMPADVLAVDNDVGAQINVNPLDELDLSQPMSPEDSKVGIKTERQSPDMELLFEDANNEQDEDYEDDEDDDTDDLIVTRSGRKRKRDVAKPAKTKRGTVSVGRKGKEKMVVKRGPPKRIFKMERLPPFCKEDEELIKRYIVMGCELCIFLAEDFDGIREHFKDKHPDERPYIKCCGRKLNKRCLIQEHARRHENPEYIKCKDCGKVFANSSVLRAHWLVHHVPDEECDFQCEDCGKRFSRRNLLELHKGSHVPVNERKFICPQCPKHNAFATEYHMQVHISMQHRKAANICHVCGKKIKDKAVFEKHVRLHFEESGPRIKCPRPDCESWLKDEDNLKQHLRRHNDEGKLFICSECGKSCKNSRALIGHKRYSHSNVIYTCEQCGKTFKKDISLKEHMAQHTGEPLYKCPFCPRTFNSNANMHSHKKKMHPVEWDIWRKTKTGSSQKVLPSAQVAQMFRDDADVAAIANDYSG