lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MQFSRNFMIICSALLLCSSLTYGQTATPPAPVAMTPTPTPAPAPAPEYVNLTYLLSVAGPFHTFLNYLESTKVIDTFQNQANNTEQGITIFVPKDDSFKGLKKPSLSKLSDDQLKSLILFHALPKYYALADFNDLSTKGPITTLAGGQYTLNFTDDSGTVHLDSGWSKTKVASAVHSTDPVAIYQVNKVLLPEAIFGTDIPPTPAPSPAPDISPAADSPSADSKEGGSPSKALPSDSAAHRVMKLSIWSHLVLAVLGGFVLLF
The following text describes a protein:
Function:
Catalyzes the oxidation of D-galacturonate and D-glucuronate to galactarate and D-glucarate, respectively. In fact, in water solution the substrate D-galacturonate is predominantly in pyranosic form whose beta anomer is converted by the enzyme to D-galactaro-1,5-lactone; in solution, this reaction product rearranges to the more stable D-galactaro-1,4-lactone. Makes part of the oxidative degradation pathway of D-galacturonate, which allows A.tumefaciens to utilize D-galacturonate as a sole carbon source. Cannot use NADP(+) instead of NAD(+) as cosubstrate. Is not active on D-galactose, D-glucose, D-galactonate and D-gluconate.
Miscellaneous:
MISCELLANEOUS: D-galactaro-1,4-lactone was previously believed to be the product of the reaction of D-galacturonate oxidation.
Sequence:
MKRLLVTGAAGQLGRVMRERLAPMAEILRLADLSPLDPAGPNEECVQCDLADANAVNAMVAGCDGIVHLGGISVEKPFEQILQGNIIGLYNLYEAARAHGQPRIVFASSNHTIGYYPQTERLGPDVPARPDGLYGVSKCFGENLARMYFDKFGQETALVRIGSCTPEPNNYRMLSTWFSHDDFVSLIEAVFRAPVLGCPVVWGASANDAGWWDNSHLGFLGWKPKDNAEAFRRHITETTPPPDPNDALVRFQGGTFVDNPIFKQS
The following text describes a protein:
Function:
DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
Subcellular Localization:
Nucleus.
Sequence:
MLRRTFLRRDHRENIIRIFQEMADLNNALGEKYKVSSYHRSIESLKTNLDKPLNTPQDLKAFSGFGTKLLKKAEEIMATGKLEELESKTKPKLKAIQELTQVHGFGPRAAAALFDREGIFTVDELLQKADSIPSLTDQQRVGIKYFYDINEKIPMQESVLHENYLRDKCMEVLGKDFSILICGSYRRRHPFSGDVDAILSRTLDAPPLSEPVAATGVLGHFVEFLESLKYLEATMAQGPLKYMGMGRLPPRIVRDKAGRENTKVYKARRVDIRLIETKSVPTAMLTFTGSKNFNVIMRQAAISKGYLLNEYGLFKLGTPEEARALYERIGIRGKNAGEELGVPKDELEDKRVEVRSEQDVFDVLGMPYAKPENRDP
The following text describes a protein:
Function:
Functions as an mRNA export adapter; component of the transcription/export (TREX) complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Plays a key role in mRNP recognition and mRNA packaging by bridging the mRNP-bound EJC and the TREX core complex. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling. Acts as a chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. Involved in transcription elongation and genome stability (By similarity).
Subcellular Localization:
Nucleus. Nucleus speckle. Cytoplasm. Note=Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Sequence:
MGDKMDMSLDDIIKLNRSQRPSGRGRGGGRGARGGSARGGAGGRIGGGRGGGAPGVGGPMRSRPVLSRGGRNRPTPYSRPKQLPDKWQHDLFDSGFGAGAGMETGGKLLVSNLDFGVSDADIQELFAEFGTLKKAAVHYDRSGRSLGTADVHFERKADALKAMKQYNGVPLDGRPMNIQLVTSQIEAQRRPIQSQSRGGGVTRPRGGTLGFASGNRRGRGGNRGRGRGAGRNPKQQLSAEELDAQLDAYNARMDTS
The following text describes a protein:
Function:
Probable serine protease inhibitor.
Domain:
The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity).
Sequence:
MAALAAGEPFSGRATGGDGGVRSDVMAPPAMAEEAKVSCLPLAREVGRRAAAAGGGQGRNFIVSPLSFHAALALVADGARGETQRELLGFLGSPSLAELHRSPTTRLVARLRHLPNTSFACGVWVDRGRALTPEFADAAASRYAAVAEPADFATQPEQARERVNAFVSDATEGLIRDVLPPNSVDSSTVVVLANAVHFKGTWSLPFHPSATFHAPFHLLDGGAVRAPFMTTEIPFERHVAAFPGFTALKLPYKNVGGGGGGDGVPRAAFYMLLLLPDGDGALKLADLYDMAVTTPEFIKKHTPAAEAPVRRLMVPKFKFSFKFEAKSDMRKLGVTRAFAGGDFSGMVTGGDGLFIAEVYHQATIEVDELGTVAAASTAVVMMQKGSSLPPVDFVADRPFLFAVVEELTGAVLFLGHVVNPLAE
The following text describes a protein:
Function:
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Melanosome.
Sequence:
MDFETLASGLNCTPPAIDDFPRDFFTEKERQDGAVVVHVVVSLYLFVALAVVCDKFFVPAVEKICHALNMSADVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGLCGVKVVPLDWWPLTRDCLAYGITVSILICIIHDERVEWYEALTLVLLYTVYILIMYFDKSIQRCARGEYHTLPLQSPSKLVLHENAPLLGGFKSAQPPHDSTPQSIEAAEAHLPLQPNKEIKDISDNHNTENVVVVPSHLNGSLKVPEAETEEAKKTEPTNMVEDEPHSLWKWPAGRSKFTQFTWVITWPIHLIFLFTIPDCEKPRFKKWFPLTFIMCIIWIGSLSYVVAWMITIIGDTLKIPDSVMGITFLAAGTSIPEAVSSVIVAKQGHGSMGISNSIGSNTFDILLCLGLPWFIKATFMPTIAGKHWVGINSAGIEYSAISLLSSLLLLYLVFAVNKFRLDKRVGRICLLMYAIFLILASLIELNAFFRVNLPTCGR
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Sequence:
MSGWRLLLTRPDEECAALAASLGEAGVHSSSLPLLAIDPLEETPEQRTLMLDLDRYCAVVVVSKPAARLGLERLDRYWPQPPQQTWCSVGAATAAILEAYGLDVTYPEQGDDSEALLALPAFQDSLRVHDPKVLIMRGEGGREFLAERLRGQGVQVDYLPLYRRRAPDYPAGELLARVRAERLNGLVVSSGQGLQNLYQLAAADWPEIGRLPLFVPSPRVAEMARELGAQRVIDCRGASAPALLAALTSAA
The following text describes a protein:
Function:
May regulate voltage-dependent calcium channels.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MARQPEEEETAVARARRPPLWLLCLVACWLLGAGAEADFSILDEAQVLASQMRRLAAEELGVVTMQRIFNSFVYTEKISNGESEVQQLAKKIREKFNRYLDVVNRNKQVVEASYTAHLTSPLTAIQDCCTIPPSMMEFDGNFNTNVSRTISCDRLSTTVNSRAFNPGRDLNSVLADNLKSNPGIKWQYFSSEEGIFTVFPAHKFRCKGSYEHRSRPIYVSTVRPQSKHIVVILDHGASVTDTQLQIAKDAAQVILSAIDEHDKISVLTVADTVRTCSLDQCYKTFLSPATSETKRKMSTFVSSVKSSDSPTQHAVGFQKAFQLIRSTNNNTKFQANTDMVIIYLSAGITSKDSSEEDKKATLQVINEENSFLNNSVMILTYALMNDGVTGLKELAFLRDLAEQNSGKYGVPDRMALPVIKGSMMVLNQLSNLETTVGRFYTNLPNRMIDEAVFSLPFSDEMGDGLIMTVSKPCYFGNLLLGIVGVDVNLAYILEDVTYYQDSLASYTFLIDDKGYTLMHPSLTRPYLLSEPPLHTDIIHYENIPKFELVRQNILSLPLGSQIIAVPVNSSLSWHINKLRETGKEAYNVSYAWKMVQDTSFILCIVVIQPEIPVKQLKNLNTVPSSKLLYHRLDLLGQPSACLHFKQLATLESPTIMLSAGSFSSPYEHLSQPETKRMVEHYTAYLSDNTRLIANPGLKFSVRNEVMATSHVTDEWMTQMEMSSLNTYIVRRYIATPNGVLRIYPGSLMDKAFDPTRRQWYLHAVANPGLISLTGPYLDVGGAGYVVTISHTIHSSSTQLSSGHTVAVMGIDFTLRYFYKVLMDLLPVCNQDGGNKIRCFIMEDRGYLVAHPTLIDPKGHAPVEQQHITHKEPLVANDILNHPNFVKKNLCNSFSDRTVQRFYKFNTSLAGDLTNLVHGSHCSKYRLARIPGTNAFVGIVNETCDSLAFCACSMVDRLCLNCHRMEQNECECPCECPLEVNECTGNLTNAENRNPSCEVHQEPVTYTAIDPGLQDALHQCVNSRCSQRLESGDCFGVLDCEWCMVDSDGKTHLDKPYCAPQKECFGGIVGAKSPYVDDMGAIGDEVITLNMIKSAPVGPVAGGIMGCIMVLVLAVYAYRHQIHRRSHQHMSPLAAQEMSVRMSNLENDRDERDDDSHEDRGIISNTRFIAAVIERHAHSPERRRRYWGRSGTESDHGYSTMSPQEDSENPPCNNDPLSAGVDVGNHDEDLDLDTPPQTAALLSHKFHHYRSHHPTLHHSHHLQAAVTVHTVDAEC
The following text describes a protein:
Function:
Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVIGRIHSFESCGTVDGPGIRFITFFQGCLMRCLYCHNRDTWDTHGGKEVTVEDLMKEVVTYRHFMNASGGGVTASGGEAILQAEFVRDWFRACKKEGIHTCLDTNGFVRRYDPVIDELLEVTDLVMLDLKQMNDEIHQNLVGVSNHRTLEFAKYLANKNVKVWIRYVVVPGWSDDDDSAHRLGEFTRDMGNVEKIELLPYHELGKHKWVAMGEEYKLDGVKPPKKETMERVKGILEQYGHKVMF
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cellular thylakoid membrane; Multi-pass membrane protein. Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MNYFPWLTIIVVFPIFAGSLIFFLPHKGNRVIRWYTICICILELLLTTYAFCYHFQSDDPLIQLVEDYKWINFFDFHWRLGIDGLSIGPILLTGFITTLATLAAWPVTRDSRLFHFLMLAMYSGQIGSFSSRDLLLFFIMWELELIPVYLLLCMWGGKKRLYSATKFILYTAGGSVFLLMGVLGLALYGSNEPTLNFETSVNQSYPVVLEIIFYIGFFIAFAVKSPIIPLHTWLPDTHGEAHYSTCMLLAGILLKMGAYGLIRINMELLPHAHSIFSPWLMIIGTIQIIYAALTSLGQRNLKKRIAYSSVSHMGFIIIGISSLTDTGLNGALLQIISHGFIGAALFFLAGTTYDRIRLVYLDEMGGIAIPMPKMFTMFSSFSMASLALPGMSGFVAELIVFFGIITGQKYLLIPKILITFVMAIGMILTPIYSLSMSRQMFYGYKLFNAPKDSFFDSGPRELFLSISIFLPVIGIGIYPDFVLSLAVDKVEVILSNFFYR
The following text describes a protein:
Function:
Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Sequence:
MSNPYLEAIAKTIDIKITHRVIVSATVSDEILSKLNEIPFNAKPVVENHNLLWYGSDGLFLVESLWEYIQKTQNISLTFAQKYGRIWSALRKTPTTLQVSKIVPEAIIPSKAHPLDTGYDISVIRVVKENFGPGVTLYGTGLIIRPPDGYYVDMVARSSLCKSGYFVANCVGIIDAQYRGELCVPLAKISPDAKPLELPARIVQIIIRELHVCDIEEVADINSTSRGTGGFGSSGK
The following text describes a protein:
Function:
Required for the differentiation of chloroplast from proplastids or etioplasts, probably by modulating some chloroplast-encoded genes expression and mRNA maturation. Involved in leaf-cells differentiation.
Subcellular Localization:
Plastid, chloroplast. Plastid, chromoplast. Plastid, etioplast. Plastid, amyloplast. Note=Present in thin tubular projections emanating from plastids and often connecting organelles each other.
Sequence:
MAATSLVLTCASPLFSSPRVISATKKLTTELSISTAKFRRRCSGNNDEVLLEGMPPEYYDDEWQARQREKTKELRRMQREEEEEEERKIEEYREIGTRLKEFPEQDLRKARKLVSSFIRAAEEVEERIEEAAEKGELDELVLMIIWNRLDLARRDDEKDAIRSLDLLYRRVETEILKRQASPAMKLLNDLLNMHDGFEDDAWLKDCRKRMAETFPREDPFSILMPPGFDIDMHQGQLRPPIETETDNTLLRVDFVREVDALLQEVRIEEDATTGSKGEGLDPEAIALKFKQQEKQRTIRQIEAILDLALNLKW
The following text describes a protein:
Function:
Catalytic component of telomerase, an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER. TERT is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MQKINNINNNKQMLTRKEDLLTVLKQISALKYVSNLYEFLLATEKIVQTSELDTQFQEFLTTTIIASEQNLVENYKQKYNQPNFSQLTIKQVIDDSIILLGNKQNYVQQIGTTTIGFYVEYENINLSRQTLYSSNFRNLLNIFGEEDFKYFLIDFLVFTKVEQNGYLQVAGVCLNQYFSVQVKQKKWYKNNFNMNGKATSNNNQNNANLSNEKKQENQYIYPEIQRSQIFYCNHMGREPGVFKSSFFNYSEIKKGFQFKVIQEKLQGRQFINSDKIKPDHPQTIIKKTLLKEYQSKNFSCQEERDLFLEFTEKIVQNFHNINFNYLLKKFCKLPENYQSLKSQVKQIVQSENKANQQSCENLFNSLYDTEISYKQITNFLRQIIQNCVPNQLLGKKNFKVFLEKLYEFVQMKRFENQKVLDYICFMDVFDVEWFVDLKNQKFTQKRKYISDKRKILGDLIVFIINKIVIPVLRYNFYITEKHKEGSQIFYYRKPIWKLVSKLTIVKLEEENLEKVEEKLIPEDSFQKYPQGKLRIIPKKGSFRPIMTFLRKDKQKNIKLNLNQILMDSQLVFRNLKDMLGQKIGYSVFDNKQISEKFAQFIEKWKNKGRPQLYYVTLDIKKCYDSIDQMKLLNFFNQSDLIQDTYFINKYLLFQRNKRPLLQIQQTNNLNSAMEIEEEKINKKPFKMDNINFPYYFNLKERQIAYSLYDDDDQILQKGFKEIQSDDRPFIVINQDKPRCITKDIIHNHLKHISQYNVISFNKVKFRQKRGIPQGLNISGVLCSFYFGKLEEEYTQFLKNAEQVNGSINLLMRLTDDYLFISDSQQNALNLIVQLQNCANNNGFMFNDQKITTNFQFPQEDYNLEHFKISVQNECQWIGKSIDMNTLEIKSIQKQTQQEINQTINVAISIKNLKSQLKNKLRSLFLNQLIDYFNPNINSFEGLCRQLYHHSKATVMKFYPFMTKLFQIDLKKSKQYSVQYGKENTNENFLKDILYYTVEDVCKILCYLQFEDEINSNIKEIFKNLYSWIMWDIIVSYLKKKKQFKGYLNKLLQKIRKSRFFYLKEGCKSLQLILSQQKYQLNKKELEAIEFIDLNNLIQDIKTLIPKISAKSNQQNTN
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MKVVVNEMSQVVEIITNEGVISVELYDTFAPRAAESFRRFAESGQLDGAVFDRMVPTFLLECRLSEFSVYGELVGREENNHLHHTGAGILTCFGTVLESGAFFITLGPQPELDNVCTIFGRVRSGMRVVEKISRSRVAEKTFRLYTPVVVERCLTRVLPKERRPECVGGEQLDVLPQSVSRHCGTQSSILNDLE
The following text describes a protein:
Function:
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome.
Sequence:
MNQQTNHNDLETTNSNQLVNDNNYTEDINTRMKVPTKLSALQENGDDYPAPYQQMSTFSADQERYIAANPALRMEVPERIVVSVGESGSKFSAGDARSSSPLFDQPYAATVSLATPPRVLTVQDSPLYRNSEETHSSHKANHSTDSLLAYSDQMALTDLSSTEDLDDVSLMKKQIFKLHRRITVLEKHQSDTNRINYCVYGFTVAFWLLNGWFLYNHRRLY
The following text describes a protein:
Function:
Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.
Sequence:
MISIVLVSHSQKITEGLQEMIVEMVGDTVHIISSGGTGDGRLGTNAIMIADNIATCTNSEHIYIFCDIGSAILSAETALELLDTDLLEKTTIIDAPLVEGAFTAAVQSLVNPSKEAILQELTNVH
The following text describes a protein:
Function:
Works in parallel with axl-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Inhibits Wnt signaling, which affects tissue specific expression of Hox genes, egl-5, lin-39 and mab-5. This in turn affects QR (postembryonic neuroblast) cell migration, vulval cell fate specification, and the development of sensory structures by the seam cell lineage. Has a role in alae V cell patterning, ray formation in the male tail and axon guidance. Does not affect B cell polarity.
Subcellular Localization:
Cell membrane. Nucleus. Cytoplasm, cell cortex. Note=Subcellular location was measured using a GFP reporter gene. Location of the pry-1:GFP fusion protein ranges from plasma membrane and cytoplasmic dots to diffuse cytoplasmic and nuclear staining. This difference may be due to variations in expression levels of the fusion protein in different transgenic lines.
Sequence:
METHLGWARSLEAVLSDRSALDAFQEWLIEYSSPQYLDLFFAIRAYERMALEGKPEKSQLSKSIYSKFLSSRTGNCEAIPKHFRAPIGEKLRHGTELEDRVFSHCSNFVQEFLRRQHEEFVGSEEFIEAFNKMSSTTADQLPGGSAHHSSHQNTMRRSSGTTSRKSAAQIATQLTAEALLKSKHDRHSKLGETKLEKMYPPTRQPYVCNATTSHNDSAVSSTFSGDTPEAHRMHSNRLRHIRDEQARENHGTMTLPRVEKASVDGQQWDHSSESGRRNFAMEITRKLLRHIDKVKLNDEMEKRIDDIEECRYTTIDMVNGTEPNDDLGKIDEDEELDDYLKMKMTDDSQKGSTNRSPKGPAGEPNKSGEGSKNTTLSPTNRAPAQLHNTIRVPRRKDYPRDTSASLKSHRHHQIDTNRMMSQSMCAPSYSSASSSYSRDSFAPAPTTRVNFAPGSSKSSQFYDSSGIGSMAPSAFSATSSLDYKDRRQHRKAPTPKKHSKIGKNLSNLITISYLGTDKIPVVTHVPNDGPMTLAEFKRHFALPNGAHQLFFKTECEDGSAPFQLLLIKDEHHLLPVFEGRIAAELR
The following text describes a protein:
Function:
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Sequence:
MSKKNVDPFSDSDSSSEPPSIFSSDNEENSDVDNSVIINDKNTKSDEADIKYMDEDESSDSESESESKKKSKKSKKSKKSKKSVTKKKNNLLVGNRIITEYILIDANNYHFKSWIECFPDCKVNLKLLLFRPEWFDFFKYVESKTYFPQLESKLSSYLEKRQRIVPYPELLFNTMNVLPPGKIKVVILGQDPYPGSCISGVPYAMGCSFSVPLNCPVPKSLANIYTNLIKFNHMRKAPKHGCLASWILQGTFMINSAFTTVLNESGVHARTWESFTADLIDYLTDNYDDLIFVAWGAHAHKLCQRVDPKKHYIITSSHPSPYSVSNTMTSMSYGPNPKKVTYPSFNSVDHFGKINEHLKSRNKKPIFWDL
The following text describes a protein:
Function:
Involved in retrograde transport from early and late endosomes to late Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles.
Subcellular Localization:
Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Sequence:
MSNGNDNSLIIKNIGNNEFKFVETLHELLPEDITYDDLGSLRLSLSERLQESVKKLDANKKTYEDAKLSMGEKMDDLNSSIVSLLQELSTLQSVAENTQSSIVQMTSEIKNLDFAKQNLATSMTMLKRLQMLVTAYEKLRTLRQNQKFGEAISLMQATLQLLNFFKKYRSVERIASLSRSISEFQKSFYEQVFDTFQSQFKKESGMRGGFSPSSVQYLNELCRFIDIFAGDPPESVIRWYCRHQLEDFMKVFRENEEAGSLENLPRRYTWFKKLLQTYDQLHKPIFPPHWKVDFRLYEVFCEETKNDLSKLLKDDRLSLQVFVASLEQTLEFESFIDHRFYNTKSRFNSNFEPKERQAYNALSSVFEPHYTLYFNQQSQEFSILFENFALEKQTSTDESSQVLSSSIKLFQAYRKTLTQFVRLTRSSPLVGLKNLFIKWLRRYTQVELLDYQESSTFKDIAIRLNTAEYIYRTTIELEKRFQEISNKEFKDKMSFSEVLEVISSSRGTLLKFATGKFENVLNSDLEPLSKMDLKNIETVGDQSSYVGGAVQNMTAKASEFLSVVDLNMFARNFCDRSCESFTRQFLNAIYLAKPISEVGAEQLLLDLYSFKNALLKLPDLKQDYSITDSYINHLTIFMGYIETVLKTLLTPASPKAGFIQSYIFLVKDRSVTNFTVLLELKGVGKSDISSFLQQFSDFVKKTPQLEESSPIFKYLTINTAVEQAATRSRLSLDLAPESSRTLQNLGRLFTSKKKHV
The following text describes a protein:
Function:
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
Subcellular Localization:
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Domain:
The E7 terminal domain is an intrinsically disordered domain, whose flexibility and conformational transitions confer target adaptability to the oncoprotein. It allows adaptation to a variety of protein targets and exposes the PEST degradation sequence that regulates its turnover in the cell.
Sequence:
MVQGPNTHRNLDDSPAGPLLILSPCAGTPTRSPAAPDAPDFRLPCHFGRPTRKRGPTTPPLSSPGKLCATGPRRVYSVTVCCGNCGKELTFAVKTSSTSLLGFEHLLNSDLDLLCPRCESRERHGKR
The following text describes a protein:
Function:
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.
Subcellular Localization:
Nucleus.
Sequence:
MVNHNESSGLLALSPPEQFSFPFEPYEIQRRFMRVLFEVIEHQKVGIFESPTGTGKSLSLICAALTWLELDRRRATEGTLEQLFAKLKAESPQEPDWILEQHVERKRRELIAEEDALEERLQAIRNQEAELKRKQKSSRQHPHQFKKRKIENAHDDSDEDFAPESTNEATDEVGPNGLPRSVQEMLDKYTGPKPQHREVELEPDCVKIYFTSRTHSQLNQFISEIRKTTFQDKVRVITLGSRANLCINRSVRDKAQTLEAINEACMDLQKSDKRCPHLPSLDEQDRMNDFRDHALAQIHDIEELAELGRVQNCCPYYGSRKAVRRAQIVTLPYNLLLQNSSREALGISLEKNVVIVDEAHNLIDSILGIRAVSLSNTLISQIHKAFDTYVNKFSPKLKGTNLAHLKHLLRVFKCLLNFSKNWSKNVPPNKVRHEETVTTNTLLENSGVLDQLNVLELEKYLHESKIINKVAGYATKGADVEKKNQSAQQADSNFSRSRSTLVTAFYKMQAFILAMSNADKDGRILMVSERSTASDQPTITIKYQLLDASSSFSDIVSEARSVVLAGGTMAPLDDFHSQLFPFVSPEKILDFSCSHIVPPEHLLVRAVSKGPMGTNLQLKFSSKDDPKMQNDLGQSVANICNIIKDGVICFFPSYASLDTLTDRWKKTGLWTRLENKKKIFIEPKSAADVDKILNGYSAAVNQSTNPTSVSGGGLMLAVVGGKLSEGINFSNNLCRAVIVIGIPYPNSQSVELKERIKYVENLKGAQKDAGKNFYANLAFKAVVERSDIPRIGWVQNYGGLWLTYQRSGSVLQSTKTGRLLYDWSAL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. Plays a crucial role in maintaining the genomic stability by controlling the degradation of multiple proteins involved in mitotic progression and DNA damage. Regulates epithelial homeostasis by mediating degradation of CDKN1A and isoform 2 of TP63. Plays a regulatory role in innate immunity by negatively regulating IRF3 activation and IFN-beta production. Mechanistically, inhibits TBK1 phosphorylation and 'Lys-63'-linked polyubiquitination independently of its E3 ligase activity. Alternatively, promotes 'Lys-27' and 'Lys-33'-linked ubiquitination of IFIH1/MDA5, promoting selective autophagic degradation of IFIH1/MDA5 to inhibit antiviral response.
Subcellular Localization:
Cytoplasm. Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MASAGKVCHHTMVAGNSSPGELSLEPLILCKLCLCEHPIDKMTSLQACSCIFCTLCLKQYTQFSIREGFGSTITCPDTACTSKGILQEAEISALVPVEQLQLYQRLKLEREVHLDPCKTWCPTVDCHTVCQVETGDSGLPVPVDCSACRLKFCSVCKNIWHPGQSCQGNLPIIPPEKGILLTTDVDACIKQCPVCRIYIERNEGCAQMMCKNCRHTFCWYCLQNLDNDIFLRHYDKGPCRNKLGHSRASVMWNRTQVVGILVGLGILAVVTSPLLLLASPCIICCVCKSCRGKKKKNGPPPTA
The following text describes a protein:
Function:
Probably participates in a plant defense mechanism. Inhibits the cytopathic effects of the human immunodeficiency virus.
Domain:
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Sequence:
GDPTFCGETCRVIPVCTYSAALGCTCDDRSDGLCKRN
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MQDTVTTSALLDPSHSSVSTQDKSSTGGHTSSTSPQLSKPSITPVPAKSRNPHPRANICRMRRIIAEDPEWSLAIVPLLTELCIQHIIRNFQKNPILKQMLPEHQQKVLNHLSPDLPLAVTANLIDNENYWLRCCMHRWPVCHVAHHGGSWKRMFFERHLENLLKHFIPGTTDPAVILDLLPLCRNYVRRVHVDQFLPPVQLPAQLRPGDQSDSGSEGEMEEPTVDHYQLGDLVAGLSHLEELDLVYDVKDCGMNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANQEAARQRALNPSHFMSTITANGPENSVG
The following text describes a protein:
Function:
DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
Subcellular Localization:
Chromosome, centromere, kinetochore.
Sequence:
DEKALKAKFNELCLSGKEKARQGLLEEALADFQEAYKIHESAKLLRRIEKLKENEGDEAEEEEGEDDDGRDDIGDGFLLARELSTALYPYQKEGLLWFWKLYNRNQGGILGDDMGLGKTIQVIAFLAGMFDSELIKSALIVMPVSLITNWEKEFKKWAPGIRVYPYHGSNKRERLKNLEKIQRKNGVCLTTYGLVVSSHEALSQTSTGKDYQWDYIILDEGHKIKNVTKTSKNVRAIPAKHHFILTGTPIQNNLREMWALFDFTCQGQLLGSSKTFKQEYESPITRARERDASAYEKRIGGEMAESLRKLIQPHFLRRTKAMVLKNTKKEEEGTIKEREEQIDGSQSIPKMPSAKAPEGLKRKNDLIIWLQMSDTQLKIYSDFLGLERVKEMLMSTRSPLAELNVLKKICDHPRLLSAMACTQLGLNERDRAIIDEEDKENHLEVDLSDGSSGPSDQTLIQESGKMVFLVELLDNLREQGHRCLIFSQSRKMLDIIQRVITHRGHKVLRIDGTITSTSERQHLINTFQKNSSYTCFLLTTQVGGVGITLTAADRVVICKY