lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation. Required for sporulation. Has a role late in meiosis following DNA replication.
Subcellular Localization:
Golgi apparatus, cis-Golgi network. Endoplasmic reticulum. Preautophagosomal structure.
Sequence:
MGIYSFWIFDRHCNCIFDREWTLASNSASGTINSKQNEEDAKLLYGMIFSLRSITQKLSKGSVKNDIRSISTGKYRVHTYCTASGLWFVLLSDFKQQSYTQVLQYIYSHIYVKYVSNNLLSPYDFAENENEMRGQGTRKITNRNFISVLESFLAPMVNQ
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MDISEVEENLFAASDAKLHGDMCKTLSAIYCKVLSIFPSLESARPRSKSGIQALCSLHLALEKSKNVLQHCSTCSKLYLAITGDSVLLKFGKAKCALIDSLKRVLEIVPESIGSQILEIVSQLEGTAFSLDPSEKQVGDEIIKLLQHGRKFDDCNDNNELESFHQAAMRLGITSSRAALTERRALKKVIERARAEEDKRKESIVAYLLHLMRKYSKLFRSEVSDDNDSQGSTPCSPTVLGSLEGGGASGNGQAFERQLSKLGSFNFKPNIRRSGHIPLPPEELRCPISLQLMHDPVIIASGQTYERICIEKWFSDGHDTCPKTQQKLPHLSLTPNYCVKGLIASWCEQNGVPIPNGPPESLDFNYWRLALSESETANSRSMDSVGSCNLKGAKVFPLEESGNAEEVEGNEAENENGSPCPQEEISELNVLESYQDFLSVLNEEENLQKKCKVVKQIRLLLKDDEEARIFMGANGFVEGLLRFLDSAVREGNAMAQEMGAMALFNLAVNNNRNKESMLASGVIKLLENMISNSDAHEPGAALYLNLSCLEQAKSVIGSSKAVPFLVRLLGSETDQQSKLDALHTLYNLSTVQSNIPSLLAAGIVSALQSLLVLGDHTWTEKSIAVLINLASSPAGRDEMVSACGVISGLATVLDAGELIEQEQAVSCLLVLCNGDEKCSQMVLQEGVIPALVSISVNGTTRAREKSQKLLMLFREQRQRDHPPAAEKVKQVEINEDPMPALASAPESKPFLKSVSRRKIGKAFSFLKKSKSYTVYQC
The following text describes a protein:
Function:
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction, tight junction.
Sequence:
MYNHSRYGSPPVYSPPNANHHQNSYAPGSLAYPIQSPHPHSFYQEDIPQQNFYKWKSPPGIVRILQGTIVFLCVAIFACVASTLAWEYNYGGLGTLGGMGGYYGGYGGYGYGNGYGYNYGMTNPQAASGFMMAMAVLTFIANLGLFIASVSKTSGSKSRKFFMIILVLSAVLAIMELIATIVYVVGVNPQSQMGGSYYNSQMMMMCNQIYSPSGVDFTNQYLYHYCTVDPQEAIAIVCGFIIVILLCVTSFFASKTRRKIWQYGQPNINWDKPVTAFQEGPNVEEWVKNVPDGPPDDTATLIYSEKPQSPVKALSNNSIYKPPVDTFEARESPPMSSSLVSDSELQEQSRSRPPVHRGRRRRRNPELDESQYETDYTTAVESGDDRDLGEWDSLYPPIESDSQRQEYKKEFASDLRHYKVMCAEMDDINNQLQQLSKQLDGLTEGTTQYQGVDDEYNRLKDLKRTPDYQTKKMETKQLRNKLFHIKRMVNDYDKSRS
The following text describes a protein:
Function:
Lipoxygenase that metabolizes linoleic and alpha-linolenic acids to 13S-hydroperoxy fatty acids.
Sequence:
MVHNISLSSRKALHNVHLPYMVQLPKPTGYNVALKNAAEGYDKARRMVAWLYDIADYESSIPQTFTLQQKTDKYTWELSDNFPPHLAVVPPDQSVSAPSIFSPVRLAQTLLIMSSLWYDDHTDLAPGPEQNTMQKLTQWNQERHKDQGWLIKDMFNAPNIGLRNDWYTDEVFAQQFFTGPNSTTITLASDVWLTAFTSEAKAQGKDKVIALFESAPPNSFYVQDFSDFRRRMGAKPDEELFNDSDGAMRYGCAAVALFYLTAMGKLHPLAIIPDYKGSMAASVTIFNKRTNPLDISVNQANDWPWRYAKTCVLSSDWALHEMIIHLNNTHLVEEAVIVAAQRKLSPSHIVFRLLEPHWVVTLSLNALARSVLIPEVIVPIAGFSAPHIFQFIRESFTNFDWKSLYVPADLESRGFPVDQLNSPKFHNYAYARDINDMWTTLKKFVSSVLQDAQYYPDDASVAGDTQIQAWCDEMRSGMGAGMTNFPESITTVDDLVNMVTMCIHIAAPQHTAVNYLQQYYQTFVPNKPSALFSPLPTSIAQLQKYTESDLMAALPLNAKRQWLLMAQIPYLLSMQVQEDENIVTYAANASTDKDPIIASAGRQLAADLKKLAAVFLVNSAQLDDQNTPYDVLAPEQLANAIVI
The following text describes a protein:
Function:
Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes at the transition zone (TZ), a region between the basal body and the ciliary axoneme. Co-localizes with the tectonic-like complex.
Sequence:
MEAALSRKTAKKKRKTHTTRGYRKREQEVQKLIRATEGRISGPEHDMEALSLQFFHGFEGEMQQENDFAVEDCQESDEDSGGELAEEPTDSPSQTFIHIDLHDPPLAWGQLFKQRHYYDESLLYRPSNTLHFQLHLSDLSELKDSQIRMLNRYQEQSKSKSGKLGSDLIGQLSGQKPASFLMGKHLYRSVCHRRFQSVFFPPMPPSELKGLPSRRCLKLCLKQLRFSLHPQLLEEHRLAQQLEDLFDVYSQQRKQRICRKLREELEIARQVALKLLASAGQDQTAEVKRQLKLTRQLRQRYYAESAAQRNLLQRLLKEWAKLKELRRQQRFQCTRFQLGLRVVHPPDLEASYCAWKESFETDLAEVYREHLELFYTRLRLWTDQKSHSRTATGHSKPPRKPQFDRIMASLRKEYDKTFKDPEEPYVEVFRLHADEATARLSIPGGDQLPKARNYFLKIFLDGQFVGQSRTYRLEPDLQISINECIGVLLERSLPENLNIWLYEKSTLTPKSRRLAQISTPLVLSSKDDAVQEKLSFQALSSTQLAGDVYLYYEYRSTEGWGSALHLDDVQRLPDALRQTLLPQSLPALPQASKELVTPRPPSGRIKKSQLPSLIFAEQQLQFCGLDVLLDNRRFQLLHSRHQQRNLHTKQLRFVPALEQEISEEEPLPDGRGTVQLLEPGTYWNPIDLHKHRGRKFLQLLYEVIASQSARRAKALQTPLPLLLLAEDSDRSSGTGWTALWRAFCSVFQGQRNSLPREPSGWSGHQSAPDLFKSFCVSLHVVRATGVPVRSRHILNLNERRSSAGGDMSTSLFVTQTLMYSNVRPFVTLSYGQRLCRSRTAEGSNPTWNEQLQLQIQSQFGDLRDDLKISLFDELIEQQYSDEASDVYQRVQCNWLGEFRVPINSLLASRTFEGCIELAMPKVLVGYKRPLIDSVTNMPTDQYPEFKEAVHLWFYLSIEPGGGDLAPLHSCALACAEKPELQQYLDERRLELQQLLPQPQRYVEPLVCTAQGKRVCLTRLMDPVPLPPAAVPSGENPLEICIRYVSLLSHLRSYDPCQGFRGVWLDNQSLLDSTWCSVKDLGVLLCNYMLSLGLECWLILGVSCPHGECSFVLFRQPETAELFLVSPATGKRYQLQDVHCPLRRIYCVVGKQNIYFNIQTETRVSMTHFNLQDGACWFPLFRRRVPAPQSGVQKLDYAYKRSYELSQLQKHIERKIMKKISAWRTTRKTIWNRAFQPRLHKILCDMEDLSTFSRGRYDEPIFSEQLEREFPNYRLYGFTLNFAYTNLAAISERIRTSCIHYNHDASVEFCVAVHLHAHANDVLSVWLFLLSMVPLVE
The following text describes a protein:
Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVSGLKAELKFLASIFDKNHELFRIVSWKLDELHCQFLVPPPPPPGSSHSPPPPLTLHCNITVRRRAVAPPGRAGADGGAAVPGQRAPAPETPGVSGAAGWRLGPGPGPELRLLGPEEAEARRSTARAGFALLAPRGPRRAPRSPWPPAAVLIWGPRRVGGLLSAAQESYPSSSPIWFVDSDDPNLTSVLERLEDTKNNSSNGTTEEVTSEEEEEEEMAEDIEDLDHYEMKEEEPINGKKSEDEGIEKENLAILEKIRKTQRQDHLNGAVSGSVQASDRLMKELRDVYRSQSYKAGIYSVELINDSLYDWHVKLHKVDSDSPLHSDLQILKEKEGIEYILLNFSFKDNFPFDPPFVRVVLPVLSGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLVKGKARVQFGANKNQYNLARAQQSYNSIVQIHEKNGWYTPPKEDG
The following text describes a protein:
Function:
Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.
Subcellular Localization:
Secreted.
Sequence:
MSRLPVLLLLQLLVRPGLQAPMTQTTSLKTSWVNCSNMIDEIITHLKQPPLPLLDFNNLNGEDQDILMENNLRRPNLEAFNRAVKSLQNASAIESILKNLLPCLPLATAAPTRHPIRIKDGDWNEFRRKLTFYLKTLENAQAQQTTLSLAIS
The following text describes a protein:
Function:
Ferric chelate reductase involved in iron reduction in roots. May participate in the transport of electrons to a Fe(3+) ion via FAD and heme intermediates.
Miscellaneous:
MISCELLANEOUS: It is not clear whether or not FRO3 functions in iron import to mitochondria or is involved in iron efflux to the cytosol; MISCELLANEOUS: [Isoform 3]: May be due to intron retention.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MAARGRLVVARGNRSFSSIIRKYSLKRETNKKVIKNVIKLLTMVILMGTVVIWIMMPTSTYKKIWLKSMRAKLGKSIYFGKPGVNLLVYMFPMILLASLGSIYLHLKKQTRVNQFNSRMDRKKIDKFGALKRPMLVKAGLGIVTVTEVMFLMMFMALLLWSLANYFYHTFVTITPQSLPTDGDNLWQARLDSIAVRLGLTGNICLGFLFYPVARGSSLLAAVGLTSESSTKYHIWLGNLVMTLFTSHGLCYCIYWISTNQVSQMLEWDRTGISHLAGEIALVAGLLMWATTFPAIRRRFFEVFFYTHYLYMVFMLFFVFHVGISYALISFPGFYIFMVDRFLRFLQSRNNVKLVSARVLPCETVELNFSKNPMLMYSPTSILFVNIPSISKLQWHPFTITSSSKLEPKKLSVMIKSQGKWSSKLHHMLASSNQIDHLAVSVEGPYGPASTDYLRHDSLVMVSGGSGITPFISIIRDLLYVSSTNAYKTPKITLICAFKNSSDLSMLNLILPNSTEISSFIDIQIKAFVTREKVSTCNMNIIKTLSFKPYVSDQPISPILGPNSWLWLATILSSSFMIFIIIIAIISRYHIYPIDQSSKEYTSAYTSLIYLLAISISVVATSTVAMLCNKKSYFKGLYQNVDALSPLMIESSPDQLLPEFTNIHYGERPNLNKLLVGLKGSSVGVLVCGPRKMREEVAKICSFGSAANLQFESISFNW
The following text describes a protein:
Function:
Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing. Participates together with DDX39A in mRNA nuclear export.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly is located in the cytoplasm.
Sequence:
MEETMKLATMEDTVEYCLFLIPDESRDSDKHKEILQKYIERIITRFAPMLVPYIWQNQPFNLKYKPGKGGVPAHMFGVTKFGDNIEDEWFIVYVIKQITKEFPELVARIEDNDGEFLLIEAADFLPKWLDPENSTNRVFFCHGELCIIPAPRKSGAESWLPTTPPTIPQALNIITAHSEKILASESIRAAVNRRIRGYPEKIQASLHRAHCFLPAGIVAVLKQRPRLVAAAVQAFYLRDPIDLRACRVFKTFLPETRIMTSVTFTKCLYAQLVQQRFVPDRRSGYRLPPPSDPQYRAHELGMKLAHGFEILCSKCSPHFSDCKKSLVTASPLWASFLESLKKNDYFKGLIEGSAQYRERLEMAENYFQLSVDWPESSLAMSPGEEILTLLQTIPFDIEDLKKEAANLPPEDDDQWLDLSPDQLDQLLQEAVGKKESESVSKEEKEQNYDLTEVSESMKAFISKVSTHKGAELPREPSEAPITFDADSFLNYFDKILGPRPNESDSDDLDDEDFECLDSDDDLDFETHEPGEEASLKGTLDNLKSYMAQMDQELAHTCISKSFTTRNQVEPVSQTTDNNSDEEDSGTGESVMAPVDVDLNLVSNILESYSSQAGLAGPASNLLQSMGVQLPDNTDHRPTSKPTKN
The following text describes a protein:
Function:
Transcription factor that regulates the expression of the gene clusters that mediate the biosynthesis of pseurotin and fumagillin.
Subcellular Localization:
Nucleus.
Sequence:
MDVNRKRMVRMASAQRSEMLVRLSGKAKRWTVGGGGEVETHTFHTFCAGQKSYKSVVRRQRPRIARRDSRPSHPIANRGMNMLVHDLGFSHRACDRCHGQKLRCRRENNSDTCVRCARAGVRCTPRPMRLRSRAQSTKNTQQQQSQSPANGGSTQQLHVNQEQGPNDTNDEHSDHFEYLPTSLLDMPTDLNMGMDPSSLQVDIHPALTAPYGPEGSVHTSQPSGPQAPSHLRTAEQAGQTRWSDAPNLDTSDELYDFSLPATMRSSFPATYHRHRASLARNMSPQPAHQQGRDDMMVDFDQAEGNPRGSDGKDSRADSGYGNELSPSDLLRSPYGDAPDSDSELQPRGNSQDQGEQSNSILDTRHQNMTSWIRRLSDTNVQLHQHMQSIPLVGTGKKTRGSGAGTSLSPMELPVDSTFKLSSQYTGLLTSICARLQACRSCNDSQALAQLALDQPSQLLVLSSYMCLLASYDRILQHIEAWLKVRLKMGVRGSAMTLDDDESSSCFPTQLPSLAVGSFEVPKTSSIQSLVLTCIMETNVMHMHSLISEIMRPVSHPATGSASKTAASGPPAAEKRPGNGAADAGDGLSTVAKVTLQAIEANEDSTLRLVHTVSRLALQRVML
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MTSRILQRFFTVSTSLRSLTRAEVPGEKIDAKRARLLYQSKKRGILENDILLGDFAEQNLKKMSEPELKAYDKLINGEHMEWDLFYYLSNKKSPPEDVESCQVYQKVKKFVDDKRVPKS
The following text describes a protein:
Function:
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MISKEYEFGKTSILNRKKYTLVIDEDKNGNFIRFTVLPVSNRKFKKVKQNGRVEINMGIQYHQIVLILLLNILFYVICLRSRFLEHINRTFEVTIARSFQILIIMGLFALGTIILVRGPSVETVTIFKESGLQLSRVKGMVIFPQQWNRKFFEQVEFISNERIIDVVINEGFCRGFRVIFYLAAIVRKSSTLKLLFPSNLPSIDDQRLIYNISRKYLSKQEKPLSRPKD
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MSQESQNSQSQRKSYLPSKDFASNLEPKDVIKKYDDINQQIIENEKDLITNATPRNLSEILIQMDKMQSLVKKPSVFEKDLKSINRVTRIAVEQGNQVTLSDSAFNLASVHRNLCAKYPTRKEKQFDLAQLGDIFIRSSLIAPRMNIPMLYGLDDFHVKPRQKRATQSQVRDEVTADEIKVGYKKTNEKAHSLTERGRKFFKEISNSGARPLADTISTEEGFDAMIQKAFELAHLVRDGRVCVDIENHEIVAKAAGSDMKDIDGKGRKKCVLHLRYKDYQNMLSLLNSEKPEVHHDIEIDDLF
The following text describes a protein:
Function:
Involved in the assembly of the O-repeating unit during O-antigen biosynthesis. N-acetylglucosamine transferase accountable for the alpha-D-GlcNAc-1,4-beta-D-Gal linkage within the O-antigen.
Miscellaneous:
MISCELLANEOUS: According to PubMed:32421169, the hydrophopic domain of this protein is likely to play a role in stabilizing the association of it with peripheral membrane or possibly, with the hydrophobic moiety of the acceptor substrate. However, a transmembrane domain is predicted by a program.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MKIAYVVSSKKKCGPNIVILNIVKELANKHEMEIFFLDESDDDVFECVNVKSTQIKKASDLKEHLKRFDIIHSSGIRPDALVVLCKVIYRVKCKIITTIHNYVFQDLYYSYGLVKSLIWGLLWCSIWLFFDKLVILSKNADNYYWFLPSAKKNIIYNGIDDNDCLQNKKCNYRKEFNIPDDGILAGSCANLTKCKGIDLVIQTLTKEHKIYYIVAGDGIEKHNLINLVKARKLHERVYFIDFLDEPESFMSQLDVFLMPSRSEGFGLTVLESTKLGIPVITSNIPIFMELFDQMCLTFDIKNPSTLIDVITYAKKNRLHLSQKFHAIFQDRFTSSKMATKYENVYNNLFREVL
The following text describes a protein:
Function:
Involved in stress signaling pathway that mediates cell death in response to endoplasmic reticulum (ER) stress and osmotic stress.
Miscellaneous:
MISCELLANEOUS: Over expression of NRP in protoplasts induces caspase-3-like activity and promotes extensive DNA fragmentation. Transient expression of NRP in planta causes leaf yellowing, chlorophyll loss, malondialdehyde production, ethylene accumulation, and induction of the senescence marker gene CP1.
Subcellular Localization:
Cytoplasm.
Sequence:
MENNNQSFWQFSDQLRLQASNLANLSLNDSIWSNNYISKRRDERINFDIKVGGEINSFKSKDPACDYNDNVNGSLLAMPYNNNNNNNIILGFGGVGLNGGFNKGIYSKPAFANLNNNINLNINPKGHKGKVEDELFHPSKSSKKNNNLNKKHGDNNNNDNNKDSKAAGDKRFKTLPPSESLPRDETIGGYIFVCNNDTMAENLKRQLFGLPPRYRDSVRAITPGLPLFLYNYSTHQLHGIFEAASFGGTNIDPSAWEDKKCPGESRFPAQVRVITRKTCEPLEEDSFRPILHHYDGPKFRLELNVPEALSLLDIFAEQDTFNDAFEALPA
The following text describes a protein:
Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Subcellular Localization:
Cytoplasm.
Sequence:
MLRATNNRRTSNNVEKDSLQMAKHGNGPLKPVNAQGLQTKREAREILALKPSNPAPVETAQKSQRINLQDAETKCLAMADDIYKYLVHHEKKYLLEECFMEGGEPTPKMRRILVDWLVQVHVRFHLTPETLHLTVFILDRMLQKKVTSKADLQLLGISAMFVASKFEEVYLPDIHDYEFITENTYSKKQILAMEQTILNSLNFDLSCPSSLVFLRCLSRILSENDASPIDNQAFCYTYNISKCLGELALLDSVMASTPRSHIASASMIIALEVHPVDGIEAENAVSVICKQLGASKKVIEDAVALLAEVSYKNFKQGKLVAIKNKYQSSKLAQVSNLMTDDVLEKINRMGQNAKVDASEME
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MGRRRNASLLGLVLQLALLLAAAAAAGGRAQRQAAPPPATTITHQEMNDNGAAVAATAMSVQGEAQQQQVMVGSRPPDCTGSCGPSCVGRCEAVLVRPVHPPKPPPAPTDAGAGAAAPPVKEVGDVGGGGGDDYKPLRWECKCRALPPSTATSSKSTLN
The following text describes a protein:
Function:
Member of the two-component regulatory system DesR/DesK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. Acts as a sensor of the membrane fluidity. Probably activates DesR by phosphorylation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGIILTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERVPFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERLEEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAARELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENISLLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKGHGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK
The following text describes a protein:
Function:
Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.
Sequence:
MAPSKRKASAPPQTSHVNGNPSADKKRKTTTDAPPTNPNTSSDPLRAPHPFYKDSETHGIVLRKFYPHEMSNARAQAYNDNELPRPIETLSAALAETAALRKSLPVRQAVVHWFKMDLRLHDNRSLWLASQKAKEAGVPLICLYVLSPEDLEAHLRAPIRVDFMLRTLEVLKTDLEDLGIPLWVETVEKRKEVPTKIKELMKSWGASHLFCAMEYEVDELRREAKLVKLLAEGEKGEKMAADVVHDTCVVMPGALQSGSGGQYAVYSPWFRAWIKHIEENPECLEIYEKPGPNPPGTKEKHENLFACSIPEAPEGKRLRDDEKARYHSLWPAGEHEALKRLEKFCDEAIGKYAERRNIPAMQGTSNLSVHFASGTLSARTAIRTARDRNNTKKLNGGNEGIQRWISEVAWRDFYKHVLVHWPYVCMNKPFKPTYSNIEWSYNVDHFHAWTQGRTGFPIIDAAMRQVLSTGYMHNRLRMIVASFLAKDLLVDWRMGERYFMEHLIDGDFASNNGGWGFAASVGVDPQPYFRVFNPLLQSEKFDPDGDYIRKWVEELRDLPELKGGKGGEIHDPYGRGSEKVKKKLEEKGYPRPIVEHSGARDRALDAYKRGLARDL
The following text describes a protein:
Function:
Mitochondrial DNA endonuclease involved in intron homing.
Miscellaneous:
MISCELLANEOUS: Encoded from partially processed ndh-5 mRNA that terminates with the in-frame coding sequence of the first intron.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MYLSIIILPLLGSIVAGFFGRKVGVSGAQLITCLSVIITTGLAILAFFEVGFNNIPVTINLFRWIDSEWYNILWGFQFDSLTVAMLIPVLIISSLVHIYSISYMSHDPRGRVRGKRVYGDKLSNSGEVLKLKVPSCSWKTMSGWSNYSGTVTSLKMSENKMDNRGSKSVVIDSNSTVKEQRVDGSWSIKSHLMDLRCTLRGFERNRGIKLGFNLQQGWNSAKIPSKQFDFKKKFSTYNSTLRVNPWVWSGLIDGEGSFNIIVDRNKSRKLGWRAQLKFQLSLHTKDLNLLYLLQQYLGGIGSIHLARNRDIVNYSIDSIEDLNKLIIHLENYPLLTQKAADFFLFKQAVKLVNNKAHLTVEGLNQIVNIKASMNLGLSDTLKSEFAGYTPVERPVINCDNVFLDPYWISGFVSAEGNFDVRMPSTNSKLGYRVQLRFRISTLRVDIRLMEKIVEYFGSGKIYKYGGKSAVSLTIVDFTDITNILVPFFNKYPIIGIKLYDYLDWCKIHSLMINRSHLTVEGINSISLLLGRRR
The following text describes a protein:
Function:
May play a role in the regulation of membrane traffic through the trans-Golgi network.
Miscellaneous:
MISCELLANEOUS: Present with 2270 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MSHPHSHSIYLSELPVRKPQALGNPLLRKIQRACRMSLAEPDLALNLDIADYINEKQGAAPRDAAIALAKLINNRESHVAIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFPGHPPLRYSKIQRLILTAIEEWYQTICKHSSYKNDMGYIRDMHRLLKYKGYAFPKISESDLAVLKPSNQLKTASEIQKEQEIAQAAKLEELIRRGKPEDLREANKLMKIMAGFKEDNAVQAKQAISSELNKLKRKADLLNEMLESPDSQNWDNETTQELHSALKVAQPKFQKIIEEEQEDDALVQDLLKFNDTVNQLLEKFNLLKNGDSNAASQIHPSHVSAPLQQSSGALTNEINLIDFNDLDEAPSQGNNNTNGTGTPAAAETSVNDLLGDLTDLSISNPSTANQASFGLGGDIVLGSSQPAPPVTTTNNSNNTLDLLGLSTPQSPTNSQAVNSSGFDLLMGFNPTTGTTTAPARTLVNQSPNLKIEFEISRESNSVIRIKSFFTNLSSSPISNLVFLLAVPKSMSLKLQPQSSNFMIGNAKDGISQEGTIENAPANPSKALKVKWKVNYSVNSTQAEETAVFTLPNV
The following text describes a protein:
Function:
May play a role in embryogenesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAVSAGALAFPALSVRATLNPEIKDEQANISSTTSSSQKFTYSRASPAVRWPHLNLREIYDSTPSQTLSSPVSPIAGTPDSGDVVDSIASREEQKTKDETAVATRRRRVKKMNKVALIKAKDWRERVKFLTDKILSLKSNQFVADILDARLVQMTPTDYCFVVKSVGQESWQRALEVFEWLNLRHWHSPNARMVAAILGVLGRWNQESLAVEIFTRAEPTVGDRVQVYNAMMGVYSRSGKFSKAQELVDAMRQRGCVPDLISFNTLINARLKSGGLTPNLAVELLDMVRNSGLRPDAITYNTLLSACSRDSNLDGAVKVFEDMEAHRCQPDLWTYNAMISVYGRCGLAAEAERLFMELELKGFFPDAVTYNSLLYAFARERNTEKVKEVYQQMQKMGFGKDEMTYNTIIHMYGKQGQLDLALQLYKDMKGLSGRNPDAITYTVLIDSLGKANRTVEAAALMSEMLDVGIKPTLQTYSALICGYAKAGKREEAEDTFSCMLRSGTKPDNLAYSVMLDVLLRGNETRKAWGLYRDMISDGHTPSYTLYELMILGLMKENRSDDIQKTIRDMEELCGMNPLEISSVLVKGECFDLAARQLKVAITNGYELENDTLLSILGSYSSSGRHSEAFELLEFLKEHASGSKRLITEALIVLHCKVNNLSAALDEYFADPCVHGWCFGSSTMYETLLHCCVANEHYAEASQVFSDLRLSGCEASESVCKSMVVVYCKLGFPETAHQVVNQAETKGFHFACSPMYTDIIEAYGKQKLWQKAESVVGNLRQSGRTPDLKTWNSLMSAYAQCGCYERARAIFNTMMRDGPSPTVESINILLHALCVDGRLEELYVVVEELQDMGFKISKSSILLMLDAFARAGNIFEVKKIYSSMKAAGYLPTIRLYRMMIELLCKGKRVRDAEIMVSEMEEANFKVELAIWNSMLKMYTAIEDYKKTVQVYQRIKETGLEPDETTYNTLIIMYCRDRRPEEGYLLMQQMRNLGLDPKLDTYKSLISAFGKQKCLEQAEQLFEELLSKGLKLDRSFYHTMMKISRDSGSDSKAEKLLQMMKNAGIEPTLATMHLLMVSYSSSGNPQEAEKVLSNLKDTEVELTTLPYSSVIDAYLRSKDYNSGIERLLEMKKEGLEPDHRIWTCFVRAASFSKEKIEVMLLLKALEDIGFDLPIRLLAGRPELLVSEVDGWFEKLKSIEDNAALNFVNALLNLLWAFELRATASWVFQLGIKRGIFSLDVFRVADKDWGADFRRLSGGAALVALTLWLDHMQDASLEGYPESPKSVVLITGTAEYNGISLDKTLKACLWEMGSPFLPCKTRTGLLVAKAHSLRMWLKDSPFCFDLELKDSVSLPESNSMDLIDGCFIRRGLVPAFNHIKERLGGFVSPKKFSRLALLPDEMRERVIKTDIEGHRQKLEKMKKKKMGNETNGINTRRKFVRSK
The following text describes a protein:
Function:
Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (By similarity).
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Endosome. Cell membrane; Multi-pass membrane protein. Note=Internalized at the canalicular membrane through interaction with the adapter protein complex 2 (AP-2). At steady state, localizes in the canalicular membrane but is also present in recycling endosomes. ABCB11 constantly and rapidly exchanges between the two sites through tubulo-vesicles carriers that move along microtubules. Microtubule-dependent trafficking of ABCB11 is enhanced by taurocholate and cAMP and regulated by STK11 through a PKA-mediated pathway. Trafficking of newly synthesized ABCB11 through endosomal compartment to the bile canalicular membrane is accelerated by cAMP but not by taurocholate (By similarity). Cell membrane expression is up-regulated by short- and medium-chain fatty acids (By similarity).
Sequence:
MSDAVILRSVKKFGEDNYGFESSTFYNNDKNSGLQDERKGDSSQVGFFQLFRFSSTTDIWLMFVGSLCAFLHGLSHPGVLLIFGTMTDVFIAYDTELQELKIPGKACVNNTIVWINSSLNQNVTNGTQCGLLDIESEMIKFASYYAGIALLVLITGYIQICFWVIAAARQIQKMRKISFRKVMRMEIGWFDCNSVGELNTRFSDDINRVNDAIADQMPIFIQRMTTSICGFLLGFYQGWKLTLVIISVSPLIGIGAAIIGLSVSKFTDYELKAYAKAGSVADEVISSMRTVAAFGGEKKEVERYEKNLVFAQRWGIRKGIVMGFFTGFMWCLIFLCYALAFWYGSKLVLEDGEYTAGTLVQIFLSILLGALNLGNASSCLEAFATGRAAATSIFHTIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKSGEMTAVVGSSGSGKSTALQLIQRFYDPSEGMVTLDGHDIRSLNIQWLRTQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVRAAKAANAYNFIMDLPEQFDTLVGEGGGQMSGGQKQRVAIARALVRNPKILLLDMATSALDNESEAMVQEALSKIQQGHTIISVAHRLSTVRAADVIIGFEHGTAVERGSHEELLERKGVYFTLVTLQSQGEPTANAEGIRGEEETDGVSLDNEQTFCRGSYQSSLRASLRQRSKSQLSYLAHEPPLAVVDHKSTYEEDRKDKDIPVEEEIEPAPVRRILKFNAPEWPYMLFGAVGAAVNGSVTPLYAFLFSQILGTFSLPDKEEQRSQINGVCLLFVAVGCVSLCTQFLQGYAFAKSGELLTKRLRKYGFRAMLGQDIGWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMMVNSFTNVTVAMIIAFFFSWKLSLVIMCFFPFLALSGALQTRMLTGFATQDKEALEIAGQITNEALSNIRTVAGIGKERQFIEAFEAELEKPFKTAFRKANVYGFCFGFSQCIVFVANSASYRYGGYLIPNEGLHFSYVFRVISSVVLSATALGRASSYTPSYAKAKISAARFFQLLDRQPPIKVYSSAGEKWDNFQGQVDFVDCKFTYPSRPDTQVLNGLSVSVRPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSRKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTREIPMEKVIEAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRNPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGIVIEKGTHEELMAQKGAYYKLVTTGAPIS
The following text describes a protein:
Function:
Required for the cessation of distal tip cell migration at the end of larval morphogenesis.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly nuclear localization in the distal tip cell.
Sequence:
MASKRHVGLNIRKKDEPKAAPIRVSSVFGDDDDDDNVPATATNMASASVIRVQKAAEREHQKAEAEDPTIFDYDGNYDEIQAIKNEKKEEARKADKNRESKYAENIIKAHARRQLEQFSREERQQLREREKEGDEFDDKEVFVTGAYRKQQEEVKKHREQEAEEAAFNDMTSVQKQKLWEIGMGRTLLNDLARDPTAIKQRKKEQKNVRKREDSDEEIDPKPEKSDKKPAEKLKKSIYSDDSDEEKAPKPPQKNFEGDLKPGLNTVSKKKATTHAERIRQRNYTPTPPSSDDEGARAPRARRRTSSPSPTSRKSIESRESGSRRSPEGKSEKSEKAPKISLKDKLKPKKIDKEARLDGLKEILKQRNTEEDIEAARQRYFERKEQGIVVPPL
The following text describes a protein:
Function:
Vacuolar Fe(2+) uptake transporter.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MAETNSNGGFRAPLLRSLDGELEKGKNGRPKEPWKGEVVKSIVYAGLDAIVTSFSLISSISAGHLSSVDVLVLGFANLVADGISMGFGDYVSSSTEKDVAAKERTVTEWDIINQHRSQKEELLRHYQQLGMNDTDANTVVNIFAKYRDIMIDEKMAVQKGLLPPDQADKPWKSGLITFTAFIVFGCAPLLAFIVLIPFTRNDTYKFIGACVFSAVALALLGIAKAKIAGQNYALSASITLFNGLIAGAAAYGIGWTLRNVAGLEE