lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Serine protease inhibitor that inhibits chymotrypsin (IC(50)=34.13 nM, Ki=49.85 nM), microbial serine proteases (subtilisin A (IC(50)=21.31 nM, Ki=20.51 nM) and proteinase K (IC(50)=52.56 nM, Ki=65.42 nM)), as well as human neutrophil elastase (IC(50)=11.54 nM, Ki=8.74 nM), and porcine pancreatic elastase (IC(50)=19.07 nM, Ki=11.32 nM).
Miscellaneous:
MISCELLANEOUS: Negative results: does not inhibit trypsin, plasmin, tPA, thrombin and factor Xa. Is not expressed in epidermis, silk gland and venom gland.
Subcellular Localization:
Secreted.
Sequence:
MKTLCIFLVLVVAVAAFPPFISQHDCPPNKEFGSYGDCPPSCLKNPPNFCTLKLNYGCKCKEGYVLTRYQDYESDCIKPEECPDDS
The following text describes a protein:
Function:
Catalyzes the epimerization of various hydrophobic dipeptides, such as L-Ala-L-Phe. Has epimerase activity with L-Ala-L-Thr, L-Ala-L-Met, L-Ala-L-Tyr, as well as L-Phe-L-Met, L-Phe-L-Ser and L-Phe-L-Thr (in vitro).
Miscellaneous:
MISCELLANEOUS: Part of a large, functionally divergent protein family. Protein modeling and substrate docking was used to predict the substrate specificity, prior to biochemical analysis.
Sequence:
MDISFQIQDAVASVIRAPLASPFRIATGQHDELENVFLKLTTRDGVSGYGEAAVASHITGETVPGTLANLQNAAAALRGQTVDDAESACRQFAAAFAGNHAGLAALEMALLDLSSRVRGIPFYRLFAPVAALEPRLAFSTDITVVIGSLDEARATAREFASRGFKAFKIKIGRDEQLDLARVLAVHEIAPDSQIILDANMGFSAGSMLAFLDRLAAKGVRPVLLEQPVPKMDWDGLSEITAALTGSETLVCADESVGSLADARRAIDSNAVSAINVKFMKSGILEGAEIARLAASRGIRLMLGAMMESALAVTASAHFAAGLACFDYLDMDTTFFLKGELAHSPYLDEHGRFDLHDAGPGIGVEPRFS
The following text describes a protein:
Function:
Plays a role in the activation of the host NF-kappa-B pathway by interacting with and thus activating the component MAP3K7.
Subcellular Localization:
Virion. Host cytoplasm. Host cell surface. Host nucleus. Note=Found in association with the nuclear matrix of infected cells.
Sequence:
MGVVVVSVVTLLDQRNALPRTSADASPALWSFLLRQCRILASEPLGTPVVVRPANLRRLAEPLMDLPKFTRPIVRTRSCRCPPNTTTGLFAEDDPLESIEILDAPACFRLLHQERPGPHRLYHLWVVGAADLCVPFFEYAQKTRLGFRFIATKTNDAWVGEPWPLPDRFLPERTVSWTPFPAAPNHPLENLLSRYEYQYGVVVPGDRERSCLRWLRSLVAPHNKPRPASSRPHPATHPTQRPCFTCMGRPEIPDEPSWQTGDDDPQNPGPPLAVGDEWPPSSHVCYPITNL
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
Subcellular Localization:
Cytoplasmic granule. Nucleus, nucleolus.
Sequence:
MEGPSGAPPRKPKPHSDHILRKRQSQKPQFGKTVIYVNTKTPVKALLDRCSKLISEGEKEITIYCLGAAIQRGTLLALKVCEENVGFQIHTNTFTTELIDDLEPATDDADYAIQRRFNSALKIKVSKPDLL
The following text describes a protein:
Function:
G-protein coupled receptor that plays a role in the regulation of circadian rhythms and energy metabolism. Participates in maintaining proper circadian gene expression in the suprachiasmatic nucleus (SCN), the locus of the master circadian clock in the brain. May function as a coordinator of aging-associated metabolic dysfunction, stress response, DNA integrity management, and eventual senescence. Upon binding to adropin, modulates mitochondrial energy metabolism via the p44/42-PDK4 signaling pathway, influencing pyruvate dehydrogenase activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAISTEVPSTMSVAPTSANTSAVLPALGMDRSSAQIVIETVTLVLLWVASVLGNVLVCIVVYRSRRLQSTTNYFVVSLACSDLLVAFMCMPFVLGRVVTNRWVFGGPMCSVVRFVQFTCPGATVYVLLSIAIDRFYTIIYPLSFKVSRTKAKQMIVLAWLFSALLAAPCFYFFRTEDLSQKTLCPTYYPGDWRGVLYMAAVFTVDYLVPIVLIILLYTRVVKHIWTIGVGGRKLQRTKNTVPATKVKTIKMLLVVNAVYLLTWSPFFLLHLGHVISAVGGAHARGDADPTWFIATVWIGFSSSVSNPLIYWVCNPNFRRGCREIFCMSNMKCYRSNTYAITYTTPFGKRNHVGFALDTNVTATTTAESAQPQNGHVTTSFDREAKREKKIAWPLVSNGANTYL
The following text describes a protein:
Function:
Serine/threonine-protein kinase that phosphorylates SNF1, the catalytic subunit of the SNF1 kinase complex. Acts as an activator of the SNF1 kinase complex and controls its nuclear localization upon glucose and nitrogen depletion. Also required for SNF1 kinase activation under other stress conditions like alkaline pH or presence of cadmium.
Miscellaneous:
MISCELLANEOUS: Present with 752 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Domain:
The kinase domain is not sufficient by themself for proper function and that the non-conserved N-terminal and C-terminal domains are critical for the biological activity. The C-terminus promotes interaction of ELM1 and TOS3 kinases with SNF1.
Sequence:
MDRSDKKVNVEEVNVPSNLQIELEKSGTSSSVSLRSPTKSSATNLAGMAEGARDNASIASSSVDSLNMLLERQRVRQLNHPQHQQHISSSLAKTPTTTSSFCSSGSSKNKVKETNRISLTYDPVSKRKVLNTYEIIKELGHGQHGKVKLARDILSKQLVAIKIVDRHEKKQRKFFTFIKSSKISENDKIKREIAIMKKCHHKHVVQLIEVLDDLKSRKIYLVLEYCSRGEVKWCPPDCMESDAKGPSLLSFQETREILRGVVLGLEYLHYQGIIHRDIKPANLLISGDGTVKISDFGVSLAASSTNSSDSSESLDELELAKTVGTPAFFAPEMCLGEDAFTRYNLTKENLFRGSCISFMIDIWAVGVTLYCLLFGMLPFFSDFELKLFEKIVNDPLKFPTFKEIQSNKVSKVSCEEEYEMAKDLLLKLLEKNPQKRMTIPAIKKHPFVSWDFDHVPENDEKLLSSVLEQKLRFQCNQTDQFEPISISKHELKNAVSGVGKKIKESVLKSIPLKDPSDLSNKNYLHPTETTRGRGDANVIVSEGSVLSNIKELSANDGCLNTDSDTNININDDDHYSGDDNDGHLTKRELERELNKFDDKHEAGNMVNLPINSSFASLDSFYIDNFAMARMGMSSPEAGDSVSSVPNLPSAPSSTRLGRSPVFSGVTNQPSPIRPVLPQQKSSFCATGRYDKSHNSLLRNSSSHLTSYNSGRPSSRTGRMNSRNQNLPKIPNSLSKISTTKLTELRVPKDSEIPSPAKNPNADRLRRFPVKKNTKTPAIKDPPRININSSDKSGSKNSPIKSLYQRMKQSKDNSKTFEVRRGNFFSHFNGDDDDSSSQSSVTSSGSESDSELSSTSSSCTSGTQSRNSSNNNAYSETESLPFEFGVDSEDGSGVLLRDLPNEDQIRPFLDIQPCRRMKVKSSLNLEPPSVSSSSSSSSDEDELILNVGTAGHRRRHNSSKLSELSNSPQKGSNNFMYSNGSVHDSETTITPQNMDDLTLHQALSRSQPISKPGPLVLPKRLDQKKATTETSNLTDIVEFNGNNDHRKDKNFDKVLYSRDLLKDALSSTNAGRRRSIPSNKIRGRKDASITMSTNVGNDEHARNTSCHGDKGQENGAIKQRTHERSRSLTVAELNEEKRRSALP
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in sucrose transport.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The PTS EIIB type-1 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-1 domain; The EIIC domain type-1 forms the PTS system translocation channel and contains the specific substrate-binding site.
Sequence:
MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQVEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPAARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFLPILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQGTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGSGITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWSMANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMIGGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFVMKINEDEERKK
The following text describes a protein:
Function:
Putative solute transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIPPEPPQPQLQPPPPPAPPNHVVTTIENLPAEGSGCVSLSTSSRAGMRQRIRKVLNREMLISVALGQVLSLLVCGIGLTSKYLAEDFHANTPVFQSFLNYILLFLVYTTTLAVRQGEENLLAILRRRWWKYMILGFIDLEANYLVVKAYQYTTLTSVQLLDCFVIPVVILLSWFFLLIRYKAVHFIGIVVCILGMGCMVGADVLVGRHQGAGENKLVGDLLVLGGATLYGISNVWEESIIRTLSRVEFLGMIGLFGAFFSGIQLAIMEHKELLKVPWDWQIGLLYVGFSACMFGLYSFMPVVIKKTSATSVNLSLLTADLYSLFCGLFLFHYKFSGLYLLSFFTILIGLVLYSSTSTYIAQDPRVYKQFRNPSGPVSDLPSTAQVEPSVTYTSLGQETEEEPHVRVA
The following text describes a protein:
Function:
Mce3R represses the transcription of mce3 operon and down-regulates its own expression, but does not affect the transcription of mce1, mce2 and mce4 operons.
Sequence:
MASVAQPVRRRPKDRKKQILDQAVGLFIERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSARRLTEGETEPTPRPLNADLEDLIAAAVASRALTVLWQREARYLNEDDRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHSLSLPGEELKKLLYQACMAAARTPPVCELPPLPAGDAARDEADVLFSRYETLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIRRLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTELSHASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIEDVARTWHLTRYAGVADEISGLALAILTSGAGNLLRA
The following text describes a protein:
Function:
Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ.
Subcellular Localization:
Nucleus. Note=Punctate nuclear localization.
Sequence:
MDDWKSRLVIKSMLPHFAMVGNRQEPRKLQESGKKPSWMEEEDLSFLYKSSPGRKHQGTVKRRQEEDHFQFPDMADGGYPNKIKRPCLEDVTLAMGPGAHPSTACAELQVPPLTINPSPAAMGVAGQSLLLENNPMNGNIMGSPFVVPQTTEVGLKGPTVPYYEKINSVPAVDQELQELLEELTKIQDPSPNELDLEKILGTKPEEPLVLDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQQQQQQQQPDHSSFLLQQMMQQPQRFQRSVASDSMPALPRQGCCHLFAWTSAASSVKPQHQHGNSFTSRQDPQPGDVSPSNITHVDKACKLGEARHPQVSLGRQPPSCQALGSESFLPGSSFAHELARVTSSYSTSEAAPWGSWDPKAWRQVPAPLLPSCDATARGTEIRSYGNDP
The following text describes a protein:
Function:
Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVKRSRDVAKFEKRAKARQEQDSKLAQSWQYIKDSDNEEDEDYGPRSFKEEESLGEMLPVRGEDGQIKRVMRKKGDKISKRKLEEQAERQRQEEEEEAAREAAEAAAAEQAAKEAAEKEEEDDIGDSDFEEEDEVTGEARFRKAQAEIAELADQLNEDAEENIHCLRKIRELMGRKQSFRVVQLTILSLVPIFQSIIPGYKIRPLTEAEKREKVSKEVKRLRNFETSLLQNYKAYLDYISKFSKKARGSTEGTMKRILGDSCVVAACELLKTSAYFNFRSDLVAIVVNRVGQKPYDANYFKALSTIESLFEDDFEGSAVKEIVMSLSKMIRAKKYRIDESLLNSLLKLRLLTELDARASQRHVESQQAPTAKVRKKDRVHLTKKQRKTLKEKKEIDEEMLKAEMAVSTEEREKIQGETLKIVFVLYFNILKERPQHLMAATLEGLAKFSHLINADFFGDLLEVLRELITERQIRYTDDGKQEFLETSTREALLCIVTAFVLLGGQVGESMNLDLTFFINHFYSSLYALGLNPDIELSHKSLRLDDPNTNESASNKRSKINVATEMEMVVRSFEGIFLQQKHVSRLRVQAFAKRLATICLQLPEKSCMAGLKILDRLNKKFTVMTALYSSDDRITNGVYRMDVDQPDHANPEASTIWETVLLEKHFSPDIAKAAKLVPRNVKKNKH
The following text describes a protein:
Function:
Plays a role in ciliogenesis; [Isoform 1]: Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2; [Isoform 4]: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual natural killer cells (NK) activity exerts an anti-abortive effect. Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein.
Miscellaneous:
MISCELLANEOUS: During normal pregnancy, the production is continuously increasing until the 37th gestational week and is followed by a sharp decrease after the 41st week of gestation. In pathological pregnancies, urinary levels fail to increase. Candidate for the diagnosis of threatened premature pregnancy termination.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Secreted. Note=In progesterone-treated astrocytoma cells a 57 kDa protein and isoform 1 (90 kDa) have been described, both being located in the intracellular medium and secreted. Respective predominant forms are isoform 1 in the intracellular and the 57 kDa protein in the extracellular medium; [Isoform 1]: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Secreted. Note=Localizes to centriolar satellites throughout the cell cycle; [Isoform 4]: Secreted. Note=Secreted by progesterone-treated lymphocytes.
Sequence:
MSRKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIFTPKPTLFTKKEAPEWSKKQKMKT
The following text describes a protein:
Function:
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MNNVKSGGRPVAIVAERYVVEKEIGRGSFAVVYKGHLADSSAGNVAIKAVSRSKLRNKKLLENLEIEIAILKKIKHPHIVGLLECERTGTDFYLMMEYCALGDLTFFIKKRRSLMDKHPLVRTLFEKYPPPSEHHNGLNRVLVVNYLQQLSSALKFLRSKNLVHRDIKPQNLLLSTPLVDYNDPAEFHARGFVGIYNLPILKIADFGFARFLPNTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVLYEMCCGKPPFKASNHLELFQKIKKANDVIQFPKHAALESAMVDLICGLLTFEPAKRMGFTEFFSNGLVNEDLSPYEVESEPDLETKSKNVAESNMFISEYLPTAERNKRASPIRLGDSCTLRGPCESPQGADPYPQDNTQSDQHEHLHADYSFQVEMGQDGQQADGEEKRKLYNNQEERSNEERQFGQVSNGRNQEDQLLLHQGRGQIPCEQNRQALQSHSHVAAKQIPDKDSKSSVSCQKHAASAPTKNDHRTTRLKEKTKCSYSDLLLEKEYVVVEKKSVEVNALADEFAQAGSGAPAIRLPDQHHNDASQALQMARHSSTSVSAANTAKQTLLRRNSRTLSSSGASTSRRPSLVDRRLSITSLGATNALSKALGMASLRLFGNSHQQSSNGSSTFKQNPNVTSLLSPQTFQDMTENAVLSADHQWDNSRQADVLHDDSIMKALENLTAKVYAIYSFAEVKFSQIIPLPPSSTQDPYTHKRMSNGSCAIDDEEDDIEHSPGAETYRKNSSGANANTGNYNFSLDTIHEMNLNDLPPNDLYILCTEAIVLYMKSLSLLAYAMHLTSKWWHESADKICPLKLNLLVQWIRERFNECLEKAEFLRMKTQSIQLHNGNQLSASTMVSEPVFVEKLIYDRALDISKTAAKMEMQGEYLEGCEVAYSTSLWMLEALLDDVSDEDNYNDDNLGHTGVLDKSDKEVIKRYIDSIANRLKALRRKLSR
The following text describes a protein:
Function:
Component of the intracellular auxin-transport pathway. Regulates auxin transport and auxin homeostasis. Directly involved in the regulation of nectar production. Involved in unfolded protein response (UPR) activation. Involved in the control of vein patterning. Redundantly with PIN8, inhibits the vein-formation-promoting functions of PIN5. PIN5, PIN6, and PIN8 control vein network geometry, but they are expressed in mutually exclusive domains of leaf vascular cells.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MITGNEFYTVMCAMAPLYFAMFVAYGSVKWCKIFTPAQCSGINRFVSVFAVPVLSFHFISQNNPYKMDTMFILADTLSKIFVFVLLSLWAVFFKAGGLDWLITLFSIATLPNTLVMGIPLLQAMYGDYTQTLMVQLVVLQCIIWYTLLLFLFELRAARLLIRAEFPGQAAGSIAKIQVDDDVISLDGMDPLRTETETDVNGRIRLRIRRSVSSVPDSVMSSSLCLTPRASNLSNAEIFSVNTPNNRFFHGGGGSGTLQFYNGSNEIMFCNGDLGGFGFTRPGLGASPRRLSGYASSDAYSLQPTPRASNFNELDVNGNGTPVWMKSPAAGRIYRQSSPKMMWESGQRHAAKDINGSVPEKEISFRDALKAAPQATAAGGGASMEEGAAGKDTTPVAAIGKQEMPSAIVMMRLILTVVGRKLSRNPNTYSSLLGLVWSLISFKWNIPMPNIVDFSIKIISDAGLGMAMFSLGLFMALQPKMIPCGAKKATMGMLIRFISGPLFMAGASLLVGLRGSRLHAAIVQAALPQGIVPFVFAREYNLHPDLLSTLVIFGMIVSLPVTILYYVLLGL
The following text describes a protein:
Function:
Involved in rRNA processing or maturation during ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVPNEKSFPRGGTIHSEVKTDDVSLNIVFGASQKKVKKAPKVKENLLSYETEEQNGQLEAFSAETLNMDTLQEDMLVMGVVKELTATALQIALPGRMFARTLVADISDAYTRVAKAAMSGDTSEYHDLTELFQLGRIVYGKAIKTEKLDTGRVSLLLSLKPADVHGNLHHKSIKKGFIFSGAVAEALEHGYVIESGVQGLQAFVPCEKPAQKLHVGQLAFLKVKTVHHDTHQSTCTCVQVEQDQLRIKSQNETNLDYILPGSIVKFKVAKHLKDGLKGSIMNESFSAYVNEHHLANALDTLDAYELNEDYNARVLYVMPLTKLVYLTLNLDIKTGAAVAKDQDEEEQEVEPIKVGSVVEKAKVLRLGSGGVVLLLNKKLKGIISYGSIRGNFKGNYDKDEVLSKYGRKTKHKVRILGYDVIESLYYCSDDPNVVNEKLFCLEDINAGDLVTAKIFKKDDKIKGWSVRIGKVNGILEQFYLAPNVRYDVGQSLKCRVLEVNAERKICYVSNRAEYLGKGIKILTDYASAHVGNVYMGTVVRCEDTYVLVKFGNGIKGVLHRQNLKENSSFFEGQTTKFRILTRNKDQITLTLPEDKFQLGEICPVEITNALDAGLEVKITFAAEDDEEDEDGNPKLEEFVGLIPLRLLSDHLELLHAQMRVHPAGSYTDAACIMQNIFSLRDVPYFSGQLTKDWQSVQVGDIIRSYVKHATDQVVDLMVCVRNYNKPVKVHVKMLRLNAVKNAPVELVPEQLLWVKVLSKEVETKTLTVSAKLTDVWSGDLSDTAKLVEGYLNEVAQIKAGLEEASAPISKYSVGEKINVVFKGIDATTNDWVYTVEGNGKVSALLLSSLVGTAKAPEMGSKHEAVILWIEYSSDVLLISNKKLDIAHISPSGELSTNLIGKAGMKAKVLLKLESVAVCSLKKGTNPLVICPIRLHPNDIENSGSAELRQGDFCNIAFIHDKLHIAVPETVWRLWRGVKRTAGTEVAPVKAKKAKVEESPKQKKTTIEETSAQKKVKAKAKVETKTEAKAIPTKRKAEVVEKITNGQKKTQPLTNGIVKEKPKQNGKLFFEDKTPAKNAKSETPKSNGAEGKSRLPGVSSFWEDDVNQSKEGSSDEDEELNVAETQKNAAKKKRLSAKEKAKAEIKEEQRLREIEERNADPKARLETIDQYERLVIAQPNNSISWLKYIAFLLSNTEIEKARALARRAISTISFRETQELRNMWSALLNMELVYSNNFDDVLKEALNCNDPLEIYISVVDILKKNKRKDRLSSVLTTVLNKFKTELRVWPVAAEAYFWLGKSDQVHNLLQRALRALPNQEHIPCIVSFAKLYAKHDNNDMAQTLLDDVVTSYPKRIDIWSVYVDMLIKAGLIDSARNVLERAVVQKLKPNKMQVIYKKYLQLEENHGTDATVAKVKQQAEQWVKNYAKTVK
The following text describes a protein:
Function:
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
Sequence:
MEKLFIQKRNCKNSNKVRRDGKVPGIIYGKNLNNLMFEVGEIELNNMISQVGEHGVTDINYEGTDYKVLIKEVQKDPVKKNVIHIDLENVTNSSNLINAEIPILFSGDDLIMKKGGIVQKEKNSVKVRCPEEKLPNNIMVDLSQYDIGKTFRISDLELGEDITFMENLDSTIVSIFFG
The following text describes a protein:
Function:
Inhibitor of serine proteases. Inhibits chymotrypsin, cathepsin G and human neutrophil elastase.
Miscellaneous:
MISCELLANEOUS: Possesses several potential secondary cleavage sites.
Domain:
The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity).
Sequence:
MAALQAAVSSQLAISFFSSLIVPGAEKNVVCSPLSISSALALVAAGSRGKTLKEIADALNWREDADGLAKALLAEAEKAAQNCDASCPVKTANNVWVDNEFKILDSYRDLLKSFAVNVGKADFKKHSSDETIKINSWIEDHTNKKIRDFFPPGELSEATKAVLVNALYFKGKWAEPFDMESTRDDTFHVSNSKEVQVKMMYHSAELKYFMDENSKCDLVELPYSSKAFSMMLIVPHEVEGLSAVQSSLSLSQVSGWISNVQSAAPQTVDVFLPRFKVSQKVNMKDNLKSLGINDMFSMQANLSGIAGSHDLFVSSAIHQAVIEVNEEGTEAAAATGFGVNFMSMPMQVRADKPFLFLIISNVTKSILFIGKIANPAA
The following text describes a protein:
Function:
Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MAARLVRRCTCLLREAARLAPAVSPVGQLRLPQGTQKPLTSSATSPSSRLPGLLSEFVEKEQVFTPYTGRQEVEQLIEKATQPEELLELLGSGHCLQQNHAALALIQLSRLLSEKPKDKAALIQDARFWQLLHLVNSQITVVWHGTLVKLLRSLYTLGLPATSKDLRSVEQEVRWRMRRLKYKHLAFLAESSATYMQEQGSRELLAELLVHLERRWAEIEDRRMVVAMMMKTGHLSESLMNRLEDKCLELVEQFGPEELRKVLVTLAAQNRRSVPLLRAISYHLVQKPFPLTKSILLDLAYAYGKLGFHQTQVFQRLAADLLPHTPSMTSSEVARCTKSFAFLKWLNLPLFEAFVQHVLDRAQSITLPHLCNMLLAFARVNFRPEREDPFFSLVHEKLGSELVGLEPALQVDVVWALCVLQQVREAELQAVLRPEFHTQFLGGKSPKDQSTFQKLLHINATAQLEHPEYTGPLLPTSALVPSPSALEQKMTPLQKELQETLKGLLGSADKGSFMVPTQYGWVLDAEVLLDTESQLLPLRDFVAPHLTPPSGSQPLPPGAKRLAFLRWEFPNFNSRSKDLLGRFMLARRHLLAAGFLLVDVPYYEWMELKSEWQKSAYLKDKMRKAVAEELAK
The following text describes a protein:
Function:
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Sequence:
MAPDGVEDSDYESDPDELNRSLATRRREASDDDEDDEEADDHDKLRAAIQIHSDEHSGVVVVDSDDNEGLHIEDSYGDDDDEEEDGDYGQVDDHVEYIADNNDKTIVAGNGTDDSAATDLVDGEEQKKKEPFAVPTAGAFYMHDDRFQELDAASNRRMRGGRRLWQSRDERKWGHDKFEEMNTQKQQYDRRTSRGRGRGRGQGRGQDRGQSRGNNSKEFTGNGHQNQFPKAVTRGRGARRYEVALRNGNQAPSVQTKQSQNSSVEVSHVDLGRPPTETATLETEAIQAKKNVFASSLNSASPPFYPSRSNNNLAQKDVQAGMGRLHINENPNPTGKKFGNTKSSSLWGRTAQTTSHGRGVPPHGQVLYQQSPNQGDKVSSPMQIRGMPKGTDQSCTQLPGQVFNQHSAVISLLPSSPPKTGSSENPYLSGEIESAVETGALVAKGKGSLQPSGRGSFMYGGTQFMGPAGMAAGHGNPNFPAFLPVMQFGGQHGGVPTFGMALPGYFQPEHGTGNPEMTWLPILAGPGALGGSYCPPYTVLDGSYQADKPGLPSSAGSSSQENSSNNPNDEEPMERPEVTNNGNSQRSNSNPNKQPRRYSEMSFSK
The following text describes a protein:
Function:
Required for plastoglobule development and resistance to multiple stresses. Regulates plastoglobule osmiophilic content. May be involved in the transport of lipophilic antioxidants in and out of the plastoglobule.
Subcellular Localization:
Plastid, chloroplast, plastoglobule.
Sequence:
MATSSTFSSLLPSPPALLSDHRSPPPSIRYSFSPLTTPKSSRLGFTVPEKRNLAANSSLVEVSIGGESDPPPSSSGSGGDDKQIALLKLKLLSVVSGLNRGLVASVDDLERAEVAAKELETAGGPVDLTDDLDKLQGKWRLLYSSAFSSRSLGGSRPGLPTGRLIPVTLGQVFQRIDVFSKDFDNIAEVELGAPWPFPPLEATATLAHKFELLGTCKIKITFEKTTVKTSGNLSQIPPFDIPRLPDSFRPSSNPGTGDFEVTYVDDTMRITRGDRGELRVFVIA
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MERGEGNKENLIFSTDLLNNFIKRGLFVEYEDEQRREDEEMELSLGLSMNGRFGVDPTRKVLDRSSSISDMASVVCPADNGIGDHARGVEIEKHAPPLARTHSLPIQTEEEWRRRKELQCAARMKKNSAVVVDDADTDSSNTTSGMKGVVYEIDCGDDQKLDQFINGNVTPLMPIEHLIDGNSDPPSHQTEACKVGPTTKTETNAAAMPEMPYVTTKEAGANGKKVEGFLYKYRKGGVKIVCVCHGLFLTPAQFLNHGGFHNVDHPLKHIVVNPFPLF