lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions in association with RUP2 as repressor of UV-B-induced photomorphogenesis mediated by UVR8 and HY5, likely in coordination with DHU1. Plays a crucial negative feedback regulatory role downstream of UVR8-COP1 to inhibit UVR8 function, balance UV-B-specific responses and ensure normal plant growth. Is involved in the regulation of photoperiodic flowering and vegetative development.
Miscellaneous:
MISCELLANEOUS: Overexpression of RUP1 confers an early flowering phenotype.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol.
Sequence:
MEALFCSEIPNNNIRSSINDLSSSSSYTWPMIMTSSSSSSSSPTIMNIENIPRCDWDLSLSAVVSSASTGSDAIGAIEFDPTGEIIATGGIARKIRSYRLSSLLESRDDHVTASESYICTPAKLSSLKWRPDFSGRVIGSGDYDGVVTEYDVEKQVPVSERDEHGGRRIWSVDYTLYNGSLIGASGSDDGTVQMWDPRNGGTLEETVRPGGGAAICSVEFDPFGGSSIAVGCADRNAYVYDIRRLVDPLIVLDGHTKTVTYARFMDSHTIVTGSTDGSLKQWDIDNGRRVVRTYRGHVNSRNFVGLSVWRHGGLVVSGSENNQVFVYDKRWEEPVWVCGLGHTNRFGSDRRFVSSVCLRQVDEDWCTLVAGGSDGALEIFSGKQS
The following text describes a protein:
Function:
Regulates the efficiency of a post-docking step of the release pathway. Acts after vesicle docking likely via regulating priming. May regulate the conformational changes in syntaxin. Binding of vesicles via rab-3[GTP] to Rim may signal the presence of a docked synaptic vesicle. Rim may then signal to unc-13 to change the conformation of syntaxin from the closed to the open state. Syntaxin could then engage synaptobrevin on the docked vesicle to form SNARE complexes and to prime the vesicle for release. Not required for the development or the structural organization of synapses. May play a role in regulating entry into the dauer state.
Subcellular Localization:
Synapse.
Sequence:
MDDPSMMPDLSHLSAEEREIIENVFKRQKDEEAKETQISQKASEELSELDKQITERKETSKKLVGTQDDAICQICQKTKFADGIGHKCFYCQLRSCARCGGRAQSKNKAIWACSLCQKRQQILAKTGKWFQPEEQPQPKISGSEPSPSPQPLTDDNVPEPQQRRAEPPDKMNTPNYQNNQQPRGMGMQPNHNQTQQNFMNQNQNSNQHPNQNHNQNQMQNPHQNQNHVQNNHQGANNHQQNNRRAMQQQPMSQNQANQINQMNQNQNQQQSHNQNMTQNQRNQTGPQNQQRTNDSRTMKQTPQQQPSQYQNNVGAAHQHHNQHGQQEQHHQQMNEQRTDNNRMRENTNGQGGMFNRQPSLEQTTPMNKYNHVEDDGMNQRPTFYTGNSENDQRQFDGQMQQGSQQNNQNQNQNNRNLRKNTVSRVTEEDYASSSNFESKKQRNNSSQSQSNTQGVRACPSTDDHLNRVKNRLHRQLRSMSSSEEDIIAGGGGNTLKMSTSAVVASGGKTAFHDDMGASNVQRLSEECNSEKDLLRYIYGDHKNSDSSSLGAGVGGSGGGGVLSGNSVLKSKSHALLKGSYQGGLDMQANRRRDKSLSLSPSRNDHFGTGSISGGDLLASRIRTFLSHPVTWQPSADQKKLIGHMILHRTENSAANGDLGLKIVGGRRTDTGKLGAFITQVKPGSVADTIGRLRPGDEVVEWNGQSLQNATYEQVYDSIAASRYDTSVELIVSRSAIIPGGDDFLNLTPSQMSSSAYSRVPSAYPSQFQRQLPNPDLFLDIHPALQQLSLPHSQSAVFPHNNTLTSRNRSTSSYYYSDVPDLGVPSNREMQESQAFGTGHIFGRIEVSFVYSHHDRQLSVALVRGFDLPPRSDGTPRNPYVKIFLLPDRSEKSRRQSAVIAETLMPVWDEVFYYNGLTEPMLLQRVLELTVWDYDKFGTNSFLGETLIDLASVPLDGEHSLMCILVDMDDDNPLRTVISIFKFHVIILTFLQRLKLRKASYNAPTRRPQSELNYYDHSSNYYDHISQNIDKQPHHHHLAPNDEENDEYIDDDELENDIDLATGGGARKSRTYRREKGMHGGHGYADWTQNHQRQSGYTSDHGYGRQNMIGRAYNRRQQRRPRSATALSQMEREDMYDPTRKHRDDNEYSMRESVRHGSQYYLGDQPLYEDGRYKISQGQMTPKQHNQQHQPHPLSQAHQQQQTAGVQPQHHQGFQQQQHPQQPNQQMQQMQPPMPNQGYYSDGSETLSVHSTNSMPTTMTTVNRRNMNANNTSNDNTSFAETPTANTNRVPIKETKQNSLASSSSVAGGGSAANNVMKERKKSLMTRFIPGRGAEGKRTGFARSEEVGIPGNLSSDRLTEPTPPFLKQASKESTDSAHSDKFARQCWLPVLADGPLGTFVDNLGPGQVVGRQVLASPVLGEIQIALMAGRSGIDVEIIKAKNLVVKPGVKVCPAPYVKVYLMEGKQCIAKAKTNAATKTTSPLFQQHLIFNDSPKKKTLQVTVLGDYGRMERKVFMGISQIRLEDLELGSQPLIGWYKLFHSSSLAGTGPVRKDSDVSVGGAQQ
The following text describes a protein:
Function:
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MMGKGFLDCESLVALQEMALHPIDLTASGCLSEERIQKNSLSAEGFTYSYATERVDDRCLEALQGLTEERELIKQMECMQQGAIMNRIEGFQSESRPVLHTATRAWVRDQDLHEEAAAIARHSKEEALRLAEFLYIARAKFSTLVQMGIGGSELGPKAMYFAMQGSCPSDKRIFFVSNIDPDNAAEVLREIDLEQTLVVVVSKSGTTLEPAANEELFRQAYQNKGLSIAEHFVAVTSQGSPMDDKSRYLEVFHLWDSIGGRFSATSMVGGVVLGFAFGYEAFIEFLQGAAAIDAHALTPKMRENLPLLSAMLGVWNRNLLGYPTTAVIPYSTGLKYFTAHLQQCGMESNGKSISREGKEISFRTSPIIWGDVGTNCQHSFFQSLHQGTDIVPVEFIGFLHNQRGLDCVLSGSSSSQKLFANLVAQSLALAQGRDNANSNKRFKGNRPSSILVAQQLSPRIAGSLLAFYEHKFAFQGFCWGINSFDQEGVSLGKELATQIIGIMSGNAPVEFSEARGMLRLFNVLT
The following text describes a protein:
Function:
Antimicrobial protein. Has antibacterial activity against the Gram-positive bacteria M.luteus (MIC=86.6 uM), L.monocytogenes (MIC=86.6 uM), and S.lutea (MIC=86.6 uM). Lacks antibacterial activity against the Gram-positive bacteria B.circulans and S.aureus, and the Gram-negative bacteria E.coli D31, E.coli ATCC 25922, and S.typhimurium. Has antifungal activity against P.pastoris (MIC=86.6 uM) and P.stipitis (MIC=90.9 uM), but lacks antifungal activity against A.niger, C.albicans, C.albidus, C.fructus, C.wickerhamii, F.oxysporum, S.cerevisiae, S.pombe, T.harzianum, and Z.marxianus.
Subcellular Localization:
Secreted.
Sequence:
ETESTPDYLKNIQQQLEEYTKNFNTQVQNAFDSDKIKSEVNNFIESLGKILNTEKKEAPK
The following text describes a protein:
Function:
Intracellular thiol proteinase inhibitor. Inhibits cathepsin B, but not papain.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKVGGLGATHQADKTVEDIVNAVKPSIQSKLGTNISNLKVISYKTQLVNGTNYFVKVRTENGYAHLRIYKPFSGAASLVSVQDGKAKDDEITYF
The following text describes a protein:
Function:
Specifically catalyzes the deamidation of the C-terminal glutamine of the prokaryotic ubiquitin-like protein Pup to glutamate, thereby rendering Pup competent for conjugation. Also displays depupylase (DPUP) activity, removing conjugated Pup from target proteins; is thus involved in the recycling of Pup and may function similarly to deubiquitinases (DUBs) in eukaryotes to prevent or promote proteasomal degradation of certain proteins.
Sequence:
MQRIIGTEVEYGISSPSDPTANPILTSTQAVLAYAAAAGIQRAKRTRWDYEVESPLRDARGFDLSRSAGPPPVVDADEVGAANMILTNGARLYVDHAHPEYSAPECTDPLDAVIWDKAGERVMEAAARHVASVPGAAKLQLYKNNVDGKGASYGSHENYLMSRQTPFSAIITGLTPFLVSRQVVTGSGRVGIGPSGDEPGFQLSQRSDYIEVEVGLETTLKRGIINTRDEPHADADRYRRLHVIIGDANLAETSTYLKLGTTALVLDLIEEGPAHAIDLTDLALARPVHAVHAISRDPSLRATVALADGRELTGLALQRIYLDRVAKLVDSRDPDPRAADIVETWAHVLDQLERDPMDCAELLDWPAKLRLLDGFRQRENLSWSAPRLHLVDLQYSDVRLDKGLYNRLVARGSMKRLVTEHQVLSAVENPPTDTRAYFRGECLRRFGADIAAASWDSVIFDLGGDSLVRIPTLEPLRGSKAHVGALLDSVDSAVELVEQLTAEPR
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MRFLGAGACSIVFALSEEEAREWGHLLPSHLLWQLALRLSARKLLRCPTCCDALNDFIGFRLGIGLDDKLRERCAAAYPLFAARCQEALYAELVSNFAADPRHIQLHGGRSTSDGVGTEAMTDSWPHYSTLAMEIKPKGVWRRPAVVGVVVDGVEYYLHPIKLRQCRFSLMQLLKRKRHNHSTPVSMERRCTYCPNQLLLGDGSSIVDALQHLSEHPGNNLAILHATDAGQGLNENSIDIVSSVLRRSGILSILANLQLFGSSSSCEWPVLDIELLFRWSEARNMSSVRWIVCSTCEGQFAAESCACQSELPLSLCMETCSGIHLTHFIAPPMGFEECVERFYASVTAKDVSVLVALTISEKVELPPSLSSPPKLGMDGSAAEEKSANLCSNPRVRFIECGDTPNGVTINLEHPQAAICRVGVVDLDAKWHKPLSRYFELDREVLAAWEDYKVVSAPEFHC
The following text describes a protein:
Function:
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. Required for cortical neuron differentiation and callosal axon elongation.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKRRLDDQESPVYAAQQRRIPGSTEAFSHQHRVLAPAPPVYEAVSETMQSATGIQYSVAPNYQVSAVPQSSGSHGPAIAAVHSSHHHPAAVQPHGGQVVQSHAHPAPSVAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPTPAQPAPQPTPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYAQVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRPSQNGCQIRRHSGTGATPPVKKKPKLISLKESSMADASKHGVGTESLFFDKVRKALRSAEAYENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLESFPKERATEGIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVSSLLCSGVRPDHLLLLFFCFKLDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGTSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEEEMDVDEATGAPKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYPAFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEVCVQVTDLYLAENNNGATGGQLSSQTSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIELLDTEEENSDDPVEAERWSDYVERYMSSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGREQQEKEGKEGNSKKTMENVESLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHERVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSIKKYRVKYGTVFKAP
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MACIEIRKGPWTEQEDLQLVCYVGLFGERRWDFIAKVSGLNRSGKSCRLRWVNYLRPDLKRGKITPQEECLILDLQSRWGNRWSRIARKLPGRTDNEIKNYWRTHMRKKAQERRNDPSPQSCSSCLTSDKEREGRMLEKEGTKLNKEEGGEEGKSLMEEIWKEIEDYEGEFKFSSSSSMESPLWEYSWDSLWKMETGEEESLAPMCDPHDRES
The following text describes a protein:
Function:
May be involved in neuronal migration.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MLGSSVKSVQPEVELSSGGGDEGADEPRGAGRKAAAADGRGMLPKRAKAPGGGGGMAKASAAELKVFKSGSVDSRVPGGPPASNLRKQKSLTNLSFLTDSEKKLQLYEPEWSDDMAKAPKGLGKVGSKGREAPLMSKTLSKSEHSLFQAKGSPAGGAKTPLAPLAPNLGKPSRIPRGPYAEVKPLSKAPEAAVSEDGKSDDELLSSKAKAQKSSGPVPSAKGQEERAFLKVDPELVVTVLGDLEQLLFSQMLDPESQRKRTVQNVLDLRQNLEETMSSLRGSQVTHSSLEMTCYDSDDANPRSVSSLSNRSSPLSWRYGQSSPRLQAGDAPSVGGSCRSEGTPAWYMHGERAHYSHTMPMRSPSKLSHISRLELVESLDSDEVDLKSGYMSDSDLMGKTMTEDDDITTGWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPTASRRNSTIVLRTDSEKRSLAESGLSWFSESEEKAPKKLEYDSGSLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKATDKGKLAVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSATLSKIQKSSGIPVKPVNGRKTSLDVSNSAEPGFLAPGARSNIQYRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPTKVASGRTTPAPVNQTDREKEKAKAKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNSNSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCFTPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSTPVPTPPAPPAAPTEEETEELTWSGSPRAGQLDSNQRDRNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALPMSLSAKGQLTNIVSPTAATTPRITRSNSIPTHEAAFELYSGSQMGSTLSLAERPKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSSAEERMQSEQIRKLRRELESSQEKVATLTSQLSANANLVAAFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKELRIKRQNSSDSISSLNSITSHSSIGSSKDADAKKKKKKSWVYELRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETASPSIKSSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEPEKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLKVAPGPSSGSTPGQVPGSSALSSPRRSLGLALTHSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQQEFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGLSTESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFETLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELVNGALTCKYHKCPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSAQQDQSKLYHLPPPTVGPHSIASPPEDRTVKDSTPSSLDSDPLMAMLLKLQEAANYIESPDRETILDPNLQATL
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Sequence:
MLQNNAVRTLQYDSEIRVAQQPSLSEPRVYDSHISITSQPRPEAPRIPLPVPIATVTGSRTLIPLSGYDCLADLPSVHIEQTFELNDVRLPFAALTGVSSENRYVVRSPLGDAIFAANESSTEKNRLLWGAGRPFQMHLLDKTHQEALVFRKKLAMGSMCCQAKSLEIWIPPGNLLGKVVQSPTFMQPEFFIEDESTGQLTFCVEGPVGLGFCCFSLPKDCYFKIHSGGNMRASIDHKWLASKSQYTTNIYFSDAKLTAKERALILGSAFLLEYLFFQTRF
The following text describes a protein:
Function:
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.
Subcellular Localization:
Secreted.
Sequence:
MVQSECWLLRGLLGFICLLPVCSSAAPDLCGPLKTVQDSLNATLRRRYMKMHFPINYTVQVRYEEVFRLRNISRLVNTSNEEEPVLPRDLQDLWLYVSQQGIKKVLRVLPERHPTRRKYLSDLENLFKKFETVFKEGNHEDQENVRERPESLQTIWDHLTEQDYKGWKSVTPKSILDNCYRTMLCLFKECFTKEDDNYDYCEVYNRRKERKTT
The following text describes a protein:
Function:
Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MAGVGEGDSGGVERDDIGMVAASPVASRVNGKVDADVVGRFATCCRALGIAVYQRKRPPDLAAARSGFAALTRVAHDQCDAWTGLAAAGDQSIGVLEAASRTATTAGVLQRQVELADNALGFLYDTGLYLRFRATGPDDFHLAYAAALASTGGPEEFAKANHVVSGITERRAGWRAARWLAVVINYRAERWSDVVKLLTPMVNDPDLDEAFSHAAKITLGTALARLGMFAPALSYLEEPDGPVAVAAVDGALAKALVLRAHVDEESASEVLQDLYAAHPENEQVEQALSDTSFGIVTTTAGRIEARTDPWDPATEPGAEDFVDPAAHERKAALLHEAELQLAEFIGLDEVKRQVSRLKSSVAMELVRKQRGLTVAQRTHHLVFAGPPGTGKTTIARVVAKIYCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSALDGVLFLDEAYALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRADLDKFLDTNEGLRSRFTRNIDFPSYTSHELVEIAHKMAEQRDSVFEQSALHDLEALFAKLAAESTPDTNGISRRSLDIAGNGRFVRNIVERSEEEREFRLDHSEHAGSGEFSDEELMTITADDVGRSVEPLLRGLGLSVRA
The following text describes a protein:
Function:
Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell.
Subcellular Localization:
Periplasm. Note=Exported from the cell, except a small proportion that is internally localized.
Sequence:
MKLLQRGVALALLTTFTLASETALAYEQDKTYKITVLHTNDHHGHFWRNEYGEYGLAAQKTLVDGIRKEVAAEGGSVLLLSGGDINTGVPESDLQDAEPDFRGMNLVGYDAMAIGNHEFDNPLTVLRQQEKWAKFPLLSANIYQKSTGERLFKPWALFKRQDLKIAVIGLTTDDTAKIGNPEYFTDIEFRKPADEAKLVIQELQQTEKPDIIIAATHMGHYDNGEHGSNAPGDVEMARALPAGSLAMIVGGHSQDPVCMAAENKKQVDYVPGTPCKPDQQNGIWIVQAHEWGKYVGRADFEFRNGEMKMVNYQLIPVNLKKKVTWEDGKSERVLYTPEIAENQQMISLLSPFQNKGKAQLEVKIGETNGRLEGDRDKVRFVQTNMGRLILAAQMDRTGADFAVMSGGGIRDSIEAGDISYKNVLKVQPFGNVVVYADMTGKEVIDYLTAVAQMKPDSGAYPQFANVSFVAKDGKLNDLKIKGEPVDPAKTYRMATLNFNATGGDGYPRLDNKPGYVNTGFIDAEVLKAYIQKSSPLDVSVYEPKGEVSWQ
The following text describes a protein:
Function:
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Subcellular Localization:
Nucleus.
Sequence:
MRRQKGCPYGPTNDYLLSSPIGQLLVKSCPHGLHELNQVEGINDSTFAPDESAEVKLLSQEFEDNGYTYRPVLSCLSWLDGYFRDVDRIPQVPLPPICEATCFPKGSFQGLVWRTLVEAAGPGTTLSYGQLAALCGNPGASRAVGSALRRNPLQLVVPCHRVVRGDGSPGHYSGGSRDRVKHWLLSHEGCPCPVTRH
The following text describes a protein:
Function:
Hydrolyzes p-nitrophenyl beta-D-glucoside, p-nitrophenyl beta-D-galactoside, p-nitrophenyl beta-D-xyloside, p-nitrophenyl beta-D-fucoside, p-nitrophenyl beta-L-arabinoside, cello-oligosaccharides and laminaribiose.
Subcellular Localization:
Secreted.
Sequence:
MAAAGAMPGGLLLTFLLLAVVASGAYNGAGEPPVSRRSFPKGFIFGTASSSYQYEGGAAEGGRGPSIWDTFTHQHPEKIADRSNGDVASDSYHLYKEDVRLMKDMGMDAYRFSISWTRILPNGSLRGGVNKEGIKYYNNLINELLSKGVQPFITLFHWDSPQALEDKYNGFLSPNIINDFKDYAEICFKEFGDRVKNWITFNEPWTFCSNGYATGLFAPGRCSPWEKGNCSVGDSGREPYTACHHQLLAHAETVRLYKAKYQALQKGKIGITLVSHWFVPFSRSKSNDDAAKRAIDFMFGWFMDPLIRGDYPLSMRGLVGNRLPQFTKEQSKLVKGAFDFIGLNYYTANYADNLPPSNGLNNSYTTDSRANLTGVRNGIPIGPQAASPWLYVYPQGFRDLLLYVKENYGNPTVYITENGVDEFNNKTLPLQEALKDDARIEYYHKHLLSLLSAIRDGANVKGYFAWSLLDNFEWSNGYTVRFGINFVDYNDGRKRYPKNSAHWFKKFLLK
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
SGQAGVSGGGGHAGPRGRRGRRGRRGGGAEQASGPRRLSSGRCLNRAPSKLTVPFRTPLEAEMARRSLAPYVQRPRGLVQKELTVNGSALAIRWTAEDPVFFRISVNAFLDQLSLVMRNIRGFGSPPMRSLGRGKRTDT
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGNWDDSEEDVVSTPIAVPGKWDDEDVEDNVKDSWDASDDEKETLAKTVAATVKPTTVAPVKVNKKKALAQKIAERKEEERRKTQESSNPTNDVVSAESDQQRKELLARSVRESDLENARALLGDLALTGGLSTTEGAIESFHPESRGEFDDFVKVIMKKFSTLEDQVQYTYFVESLIRELVIPINVEDTRRISSSLTAMINEKQRVLKESQNKGKKKAAKQVLKTAPAGRGDTTNYDDVYDDFDDFM
The following text describes a protein:
Function:
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The ITAM domains mediate interaction with SHB.
Sequence:
MKWTALVIVAVLQTQFPVTAAQSFGLLDPKLCYLLDGILFIYGVIVTALFLRAKFSRSADAPAYQHGQNPVYNELNVGRREEYAVLDRRGGFDPEMGGKPQRKKNPHEVVYNELRKDKMAEAYSEIGMKSDNQRRRGKGHDGVYQGLSTATKDTYDALHMQALPPR
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Subcellular Localization:
Autolysosome.
Sequence:
MGGGGPILQSRYRHIPFWFLLQQCLDRTYPEPFIFLLPTIPWGSAVTSFRNQLPPASRTNPLSDASGTMSSSSQICQNYSPEAEATVNRLANLFLQASYTYLSLKPAQDEWGGSRDAIESALNLEKGLNQTLLKLHALASSQGDPHLCDFLESHYLEEEAKLLKRLGDHLTSLGHVQNQDHRGHLREYQFERLSLKDD
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MSEFITVARPYAKAAFDFAVEHQSVERWQDMLAFAAEVTKNEQMAELLSGALAPETLAESFIAVCGEQLDENGQNLIRVMAENGRLNALPDVLEQFIHLRAVSEATAEVDVISAAALSEQQLAKISAAMEKRLSRKVKLNCKIDKSVMAGVIIRAGDMVIDGSVRGRLERLADVLQS
The following text describes a protein:
Function:
Cytoplasmic retinol-binding protein. Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (By similarity).
Subcellular Localization:
Cytoplasm. Lipid droplet.
Domain:
Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Sequence:
MPVDFNGYWKMLSNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDELHLEMRAEGVTCKQVFKKVH
The following text describes a protein:
Function:
Initiates the restart of stalled replication forks, which reloads the replicative helicase on sites other than the origin of replication. Recognizes and binds to abandoned replication forks and remodels them to uncover a helicase loading site. Promotes assembly of the primosome at these replication forks.
Sequence:
MPYFNVSIPLKLKTLTYQYDEELNLKGFAVQVPLRNRVVEGIVINKTDKPDKTVQIKKIQTVIGKAYEEKFIDFLQWMSSYYISEMGSVLRVTFFEEVIDLLSERKSKKRLKEKNPPAEPISFNVENYFLNNETISKIINLTRVGSYKTFLIQCPDFLYEIKLMIKVVRELLSEDGTILLIMPEIKEAQRLFNLLRSFNNQIVLLHSGMKHSELLFSIKEIVANKAKIIVGTRFAVFAPVKKLSLIMVGQESSWLYKAEESPRYHARDCAVMRGFIEGCPVVLTDFMPSTVSYYNALRSKYELIDDFNQSKHPNIKILRQPYQSIFHPEALLYLKLYQKEGILVTSPRSGYSLLRCSECGEVIKCEKCGYSMIFRKSTRLLECFRCGIVMKISEQCPYCSGVDMHSVGVGVERITEELKNIFSDKHVEIKEIDLESEQFQGIWVGQTGKIKKGYIADFKGAVIVDFDFFLSIPDYRTFEKAFAKVLSICQLIKQDGTLFIQTRNPGGEIFKFIRSYNFKDFYLYELKHREQTGFPPFSRLIKLMIKTKKTFPYETLDKVKEFLKNHISGEIIGPLKNQDKEEFMFIFRSKDKKRLIDELTGAIATLRTFKGISFKFEVDPVSLKI
The following text describes a protein:
Function:
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Domain:
Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
Sequence:
MKGSIPRPFIDDLLTKSDIVDVINTRVKLKKAGRDYQACCPFHHEKTPSFTVSQKKQFYHCFGCGAHGNAISFLMDYDKLEFIEAIEELAAMAGLEIPYEKRVNHSGKPQANYQTKRNLYELMQEIATFYQNQLPLNTQAQEYLQQRGLSPEIIERFQIGFVPNAMDTVLRKFGVNREEQQKLIELGMLSRNDRGNIYDKFRNRIMFPIRDKRGRTVAFGGRVLTDEKPKYLNSPETITYHKGKELYGLYEALQTNDEPKQLLVVEGYMDVVALAQFGVDYAVASLGTSTTSEQIQLILRSTEQVVCCYDGDRAGRDAAWRALENALPYLEDGRQLKFIFLPDGEEPDTYIRQYGKEKFEEYIESAQSLSEFMFAHLSPQVDFSTKEGRGKLVALAAPLIHQIPGEMLRLSLRNMLAQKLGIFDQTQLENLIPKKLEQANTQQKVTHNKIKKTPMRMVISLLMQNPELVKRMSESGVQALRAEAGFEILEKLTALCRQREGITTGQILEYFRNTSYSNPLEILATWDHLLDESDIINAFSQNYRRLNIQAIERDIEMLIAKERTEGLTNEEKTVLVHLLAGKEQQKKQLVNPL
The following text describes a protein:
Function:
Involved in pre-mRNA splicing as a component of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MSVASRIRDKLKNNLESSGGHSVVTSGTKVIRYRAGQRPDYAEAEDDQDSHFSNIQNQKSIKEAETNDPRLARFKNRSSNQDEPQSVEERKASRRRHHDDDNDNDTTTTTTTTTSRRIQKTEIIKEDDDNNNNNNNDTKKDHNDDDEDDDRRRRAKERYLKKKEEEEQKQKELEEKQQPFKDIEGESEEEGSSEYETDSEEDDEDEYWDQPPIFRPTFIKKDDRGTIKTDEQWEKEEQEQQAQLEREKEQRKIEAHRKLKDELDRDRKEQEAKELEQKEEEEYDDDEDQDGSKKLLWIQRELERVRLEIHTRLLAEFEKKEFARRRAMTDDQILKEDPSRSRTNIDNSQKKQLKFLQRDYHRGAFFQDDEYIKNKDFSAPTGEDKFNRELLPKVMQVKNFGKAGRTKYTHLKDQDTTEKDSLWNTNYNNKKKYNNNNNNSNSNSSNNNRDYNYRDRDNRS
The following text describes a protein:
Function:
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (Probable). Has a partially redundant function with PBP-2A (pbpA) during spore outgrowth.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKNIDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYEHKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQLEKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTLYDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYVNDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQVVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKPLLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIRMLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSYTPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPYIGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY