lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in B-lymphocyte antigen receptor signaling and germinal center formation.
Sequence:
MLMAGQRGTWTMGDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTIRKSYTHIRRIVPGAVSV
The following text describes a protein:
Function:
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53. Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M.
Sequence:
MAAEAQQDFRDSILPLLWDRRKRCQYLQGPARHAYGAAFLHALEQLCFEFLQRLESALPPPDLSQLYAVVWSHAPSGPRPPSLPILHRYLADMGHAPSGAVPRPLSSAQQQKGHSECSTPTKPRPQRRQLRPLRAQPLGEWAGLSTLSGRGYAAKPRPLLAPPSPSEFLGESEGESDLQRKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKIQGGSVLHLVLALRGGGARRGEGRG
The following text describes a protein:
Function:
May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MGNSYAGQLKTTRFEEVLHNSIEASLRSNNLVPRPIFSQLYLEAEQQLAALEGGSRVDNEEEEEEGEGGLETNGPPNPFQLHPLPEGCCTTDGFCQAGKDLRLVSISNEPMDVPAGFLLVGVKSPSLPDHLLVCAVDKRFLPDDNGHNALLGFSGNCVGCGKKGFCYFTEFSNHINLKLTTQPKKQKHLKYYLVRNAQGTLTKGPLICWKGSEFRSRQIPASTCSSSLFPALESTAAFPSEPVPGTNPSILMGAQQAGPASDHPSLNAAMGPAVFNGKDSPKCQQLAKNNLLALPRPSALGILSNSGPPKKRHKGWSPESPSAPDGGCPQGGGNRAKYESAGMSCVPQVGLVGPASVTFPVVASGEPVSVPDNLLKICKAKPVIFKGHGNFPYLCGNLNDVVVSPLLYTCYQNSQSVSRAYEQYGASAIQPISEEMQLLLTVYYLVQLAADQVPLMEDLEQIFLRSWRESHLTEIRQYQQAPPQPFPPAPSAAAPVTSAQLPWLASLAASSCNDSVHVIECAYSLAEGLSEMFRLLVEGKLAKTNYVVIICACRSAAIDSCIAVTGKYQARILSESLLTPAEYQKEVNYELVTGKVDSLGAFFSTLCPEGDIDILLDKFHQENQGHISSSLAASSVTKAASLDVSGTPVCTSYNLEPHSIRPFQLAVAQKLLSHVCSIADSSTQNLDLGSFEKVDFLICIPPSEVTYQQTLLHVWHSGVLLELGLKKEHMTKQRVEQYVLKLDTEAQTKFKAFLQNSFQNPHTLFVLIHDHAHWDLVSSTVHNLYSQSDPSVGLVDRLLNCREVKEAPNIVTLHVTSFPYALQTQHTLISPYNEIHWPASCSNGVDLYHENKKYFGLSEFIESTLSGHSLPLLRYDSSFEAMVTALGKRFPRLHSAVIRTFVLVQHYAAALMAVSGLPQMKNYTSVETLEITQNLLNSPKQCPCGHGLMVLLRVPCSPLAVVAYERLAHVRARLALEEHFEIILGSPSSGVTVGKHFVKQLRMWQKIEDVEWRPQTYLELEGLPCILIFSGMDPHGESLPRSLRYCDLRLINSSCLVRTALEQELGLAAYFVSNEVPLEKGARNEALESDAEKLSSTDNEDEELGTEGSTSEKRSPMKRERSRSHDSASSSLSSKASGSALGGESSAQPTALPQGEHARSPQPRGPAEEGRAPGEKQRPRASQGPPSAISRHSPGPTPQPDCSLRTGQRSVQVSVTSSCSQLSSSSGSSSSSVAPAAGTWVLQASQCSLTKACRQPPIVFLPKLVYDMVVSTDSSGLPKAASLLPSPSVMWASSFRPLLSKTMTSTEQSLYYRQWTVPRPSHMDYGNRAEGRVDGFHPRRLLLSGPPQIGKTGAYLQFLSVLSRMLVRLTEVDVYDEEEININLREESDWHYLQLSDPWPDLELFKKLPFDYIIHDPKYEDASLICSHYQGIKSEDRGMSRKPEDLYVRRQTARMRLSKYAAYNTYHHCEQCHQYMGFHPRYQLYESTLHAFAFSYSMLGEEIQLHFIIPKSKEHHFVFSQPGGQLESMRLPLVTDKSHEYIKSPTFTPTTGRHEHGLFNLYHAMDGASHLHVLVVKEYEMAIYKKYWPNHIMLVLPSIFNSAGVGAAHFLIKELSYHNLELERNRQEELGIKPQDIWPFIVISDDSCVMWNVVDVNSAGERSREFSWSERNVSLKHIMQHIEAAPDIMHYALLGLRKWSSKTRASEVQEPFSRCHVHNFIILNVDLTQNVQYNQNRFLCDDVDFNLRVHSAGLLLCRFNRFSVMKKQIVVGGHRSFHITSKVSDNSAAVVPAQYICAPDSKHTFLAAPAQLLLEKFLQHHSHLFFPLSLKNHDHPVLSVDCYLNLGSQISVCYVSSRPHSLNISCSDLLFSGLLLYLCDSFVGASFLKKFHFLKGATLCVICQDRSSLRQTVVRLELEDEWQFRLRDEFQTANAREDRPLFFLTGRHI
The following text describes a protein:
Function:
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
Subcellular Localization:
Nucleus.
Sequence:
MKHPFQILITNKKGTHIFAIVKNYLQVFDISKGGGDDDIKVGEWQDTTESNHPKIQIEKRTGRQISTQQIHNHLRYLILTPDEQHIIASTDSDKSILIFKIDFNNSINCLKLIKRQPIPKRPSSITIDSQGQRAIVADKFGDVYTVSINDDSSMSEIEIEIEKDIQPILGHVSMLTDITMATTHHNNNNNNNNNNNNKQFIITADRDEHIRISNYPKSYVIKNFLFGHDEFVSQLYIPVQYDPSILISGGGDDFINIWKWYEGELIETIQLRQYIESYLSDDHLPPTRFRTETSPKEISIAKIATLRTNDEEEEEDHLLIVLVENTPVLLVFNLDDSYKAKYLQAIIVNDSIIDFAIAADNKTIITSLESEQHSIKYFTLQEENDGKKFSEIQGPNIEQFIPIEVEQKSDFQQLYTIFQLRKRSDS
The following text describes a protein:
Function:
Extracellular metalloprotease that contributes to pathogenicity.
Subcellular Localization:
Secreted.
Sequence:
MKWTSILCLAPLVAASPLAARDANPSYDGYHVYSVTPASAQEAHDLERRFSRYHTHPIRDSLSIAIPPEDVAHFNTLGLNARLLNTDLGSSIRSADKPSTFNRALHKRGELPDLSWFDTYHDYADHLTWWDDLAQAFPKNSEKLEIGKSYENRSIHAFHLFGDEKESERKDKPVILWHATVHAREWISTMVIEYLAYQLVDGYKSGDGNVTSFLDHYDFYLVPFHNPDGFLYTQTNDRLWRKNRQPRPSVNTTCLGTDGNRNWATEWAAEPPGGGSTPDPCGQTYRGLAPGDTPENQAMDGLSAKLGATPAGIRSFIDFHSYSQLILTPYGYSCDPLPETLPRMLEVANGTAQAIMAASERGSIYDFGPGCQILYFSTGNSRDHHYVAHGAKHSWTMELSPQDAAGGWLRLATRGDLASSEGTVGRSIMDTEQCSGRLNWN
The following text describes a protein:
Function:
Plays a positive role in the effector-triggered immunity (ETI) response. Involved in salicylic acid (SA)-mediated processes occurring in ETI response, but is not involved in the autophagy process. Promotes systemic rather than local immunity. Essential for systemic acquired resistance (SAR), but not necessary for immune signaling downstream of SA. May act in parallel with SA.
Subcellular Localization:
Secreted, extracellular space, apoplast. Cell membrane. Note=Tightly bound to the apoplastic side of the plasma membrane.
Sequence:
MKIHKLCFLALLLAHTTSAVNLNLNLKTSELVFLGDAELGPASDGVSRSGALSMTRDENPFSHGQSLWSTPVPFKPSSNSSSPYPFETSFTFSISTRIKPAPGHGLAFVVVPSIESDGPGPAGYLGIFNKTNNGNPKNHIFAVEFDVFQDKGFGDINDNHVGININSVTSVVAEKAGYWVQTGIGKMKHWSFKEFKLSNGERYKAWIEYRNSKVTVTLAPETVKKPKKPLIVAHLDLSKVFLQNMYPGFSGAMGRGVERHDIWSWTFQNSAKRI
The following text describes a protein:
Function:
Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.
Miscellaneous:
MISCELLANEOUS: The zinc-containing form utilizes only the (S)-isomer of allantoin, whereas the cobalt-containing form prefers the (S)-isomer, but also hydrolyzes the (R)-isomer at about 1/10 the rate.
Sequence:
MSFDLIIKNGTVILENEARVVDIAVKGGKIAAIGQDLGDAKEVMDASGLVVSPGMVDAHTHISEPGRSHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLTIDAAQLGGLVSYNIDRLHELDEVGVVGFKCFVATCGDRGIDNDFRDVNDWQFFKGAQKLGELGQPVLVHCENALICDELGEEAKREGRVTAHDYVASRPVFTEVEAIRRVLYLAKVAGCRLHVCHVSSPEGVEEVTRARQEGQDVTCESCPHYFVLDTDQFEEIGTLAKCSPPIRDLENQKGMWEKLFNGEIDCLVSDHSPCPPEMKAGNIMKAWGGIAGLQSCMDVMFDEAVQKRGMSLPMFGKLMATNAADIFGLQQKGRIAPGKDADFVFIQPNSSYVLTNDDLEYRHKVSPYVGRTIGARITKTILRGDVIYDIEQGFPVAPKGQFILKHQQ
The following text describes a protein:
Function:
Transcriptional regulator involved in catabolite repression of several operons.
Sequence:
MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELDYTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPDIEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKTAYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMNDGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFPSLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA
The following text describes a protein:
Function:
Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA.
Subcellular Localization:
Host nucleus. Note=In the absence of DNA replication, found in the nuclear framework-associated structures (prereplicative sites). As viral DNA replication proceeds, it migrates to globular intranuclear structures (replication compartments).
Sequence:
MSHEELTALAPVGPAAFLYFSRLNAETQEILATLSLCDRSSSVVIAPLLAGLTVEADFGVSVRTPVLCYDGGVLTKVTSFCPFALYFHHTQGIVAFTEDHGDVHRLCEDARQKYALEAYTPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDAEADEVSLDARSAFVEARGLYVPAVSETLFYYVYTSWCQSLRFSEPRVLIEAALRQFVHDSQQSVKLAPHKRYLGYMSQRLSSLEKDHLMLSDAVVCELAFSFASVFFDSAYQPAESMLFSEWPLVTNATDHRDLIRALTELKLHLSTHVAALVFSANSVLYQHRLVYLQSSARHPSAGGTASQETLLKAIQFTNGLSAACEDVYNDARKVLKFQGAPLKDERYGPQHLALVCGTCPQLVSGFVWYLNRVSVYNTGLSGSSTLTNHLVGCAAGLCEACGGTCCHTCYQTAFVRVRTRLPVVPKQPKKEPCVITVQSRFLNDVDILGSFGRRYNVDAKDGGLDGKGDDGVPGGGAGGGGGRDVSGGPSDGLGGGRGGGGGGDSGGMMGRGGRMLGASVDRTYRLNRILDYCRKMRLIDPVTGEDTFSAHGKSDFVAVFSALNKFVDDEALGFVSEVRLKSSRDEVAGATQAFNLDLNPYAVAFQPLLAYAYFRSVFYVIQNVALITATSYIVDNPLTTNLVSKWMTQHFQSIHGAFSTTSSRKGFLFTKQIKSSKNSDHDRLLDFRLYAQGTYAVVPMEIKLSRLSVPTLIMVRVKNRPIYRAGKGNAGSVFFRRDHVPRRNPAKGCLGFLLYRHHERLFPECGLPCLQFWQKVCSNALPKNVPIGDMGEFNAFVKFLVAVTADYQEHDLLDVAPDCVLSYVESRFHNKFLCYYGFKDYIGSLHGLTTRLTTQNHAQFPHVLGASPRFSSPAEFALHVKGLKTAGVPAPMAATVARESLVRSVFEHRSLVTVPVSVEKYAGINNSKEIYQFGQIGYFSGNGVERSLNVSSMSGQDYRFMRQRYLLATRLADVLIKRSRRENVLFDADLIKNRVMLALDAENLDCDPEVMAVYEILSVREEIPASDDVLFFVDGCEALAASLMDKFAALQEQGVEDFSLENLRRVLDADAQRLTDAAGGEVHDLSALFAPSGVGAASGVGGGGLLLGESVAGNSICFGVPGETGGGCFLVNAGEDEAGGVGGSSGGGGGSGLLPAKRSRL
The following text describes a protein:
Function:
Involved in regulating the activity of the plasma membrane proton pump PMA1.
Miscellaneous:
MISCELLANEOUS: Present with 300 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MPNLLSRNPFHGHHNDHHHDRENSSNNPPQLIRSSKSFLNFIGRKQSNDSLRSEKSTDSMKSTTTTTNYTTTNLNNNTHSHSNATSISTNNYNNNYETNHHHNISHGLHDYTSPASPKQTHSMAELKRFFRPSVNKKLSMSQLRSKKHSTHSPPPSKSTSTVNLNNHYRAQHPHGFTDHYAHTQSAIPPSTDSILSLSNNINIYHDDCILAQKYGKLGKLLGSGAGGSVKVLVRPTDGATFAVKEFRPRKPNESVKEYAKKCTAEFCIGSTLHHPNVIETVDVFSDSKQNKYYEVMEYCPIDFFAVVMTGKMSRGEINCCLKQLTEGVKYLHSMGLAHRDLKLDNCVMTSQGILKLIDFGSAVVFRYPFEDGVTMAHGIVGSDPYLAPEVITSTKSYDPQCVDIWSIGIIYCCMVLKRFPWKAPRDSDDNFRLYCMPDDIEHDYVESARHHEELLKERKEKRQRFLNHSDCSAINQQQPAHESNLKTVQNQVPNTPASIQGKSDNKPDIVEEETEENKEDDSNNDKESTPDNDKESTIDIKISKNENKSTVVSANPKKVDADADADCDANGDSNGRVDCKANSDCNDKTDCNANNDCSNESDCNAKVDTNVNTAANANPDMVPQNNPQQQQQQQQQQQQQQQQQQQQHHHHQHQNQDKAHSIASDNKSSQQHRGPHHKKIIHGPYRLLRLLPHASRPIMSRILQVDPKKRATLDDIFNDEWFAAIAACTMDSKNKVIRAPGHHHTLVREENAHLETYKV
The following text describes a protein:
Function:
Catalyzes the hydration of cyanide to formamide. Degradation of cyanide may be important for plant pathogenic fungi in infection of cyanogenic plants.
Sequence:
MSPVLKKYKAAAVNAEPGWFDLEESVRRTIHWINEAGRNRCKLIAFPELWIPGYPYWMWKVNYQESLPLLKKYRENSLLSDSEEMRRIREAARANKIYVSLGYSEVDLASLYTTQVLISPAGNILNHRRKIRATHVERLVFGDGTGDTTESVVQTEIGRVGHLNCWENMNPFMKSYAASLGEQVHVAAWPLYPGKETLKYPDPYTNVAEANCDALANELPQLVTPAYAIETGTYTLAPWQTITEEGIKLNTPPGKPLEDPNIYNGHGRIFAPDGRNLVPHPAKDFQGLLYVDIDLDEIHLTKSLADFGGHYMRPDLIRLLVDGNRKDLVVSEDRINGGIKYTSTMDRVGLTKPLEAPKPTDQKE
The following text describes a protein:
Function:
Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
Sequence:
MKDPLSSCTYNLLYQELKRISKNGEFFCKELLAVFQQRSELEINYSKGLQKIAGKLLKVSKEMSDNSTYHAWSFISDEMFASADAHRILGNALNQDVIQEIRQILDEHGKRKRPLDNAVEKSGKLVLTNWSEQIKLKKKLIGLTREHEALFSFVEKNKQICTEKEKQKMFNRLSKSAELQVRVDEEYFNTNMEGHHIRLKLENTVKTCYQIVQELEKQRIETLANTLNKYSLFMTVYSQTVIHSHKQIDQAVRRVDVEKDIQSLVEDVATTADENKAEFLMADYFEEEGKTMMGKDRRKDAIRTKLQRLEDWITKSKTDREGLEKMVKVYTEQPNFSNQKNLEETEQLLEEAILKLDLLEATHCKLTHSLAEIEGKPKSRHRFSDSITKWKEKDCEHSVVQLSRPVRIKKTPFRSRQSMRATVSNETSPSPEGTGENPLNEATNSDGQKNGPVNGSVSEYEDDKGAELCCIGRCKALYSFASEREDELNINEGDVLEIFEKDDTGWWFGELNGQRGLFPSTYVEELPVFTAMKSSDA
The following text describes a protein:
Function:
Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.
Subcellular Localization:
Nucleus.
Sequence:
MATAVEPEDQDLWEEEGILMVKLEDDFTCRPESVLQRDDPVLETSHQNFRRFRYQEAASPREALIRLRELCHQWLRPERRTKEQILELLVLEQFLTVLPGELQSWVRGQRPESGEEAVTLVEGLQKQPRRPRRWVTVHVHGQEVLSEETVHLGVEPESPNELQDPVQSSTPEQSPEETTQSPDLGAPAEQRPHQEEELQTLQESEVPVPEDPDLPAERSSGDSEMVALLTALSQGLVTFKDVAVCFSQDQWSDLDPTQKEFYGEYVLEEDCGIVVSLSFPIPRPDEISQVREEEPWVPDIQEPQETQEPEILSFTYTGDRSKDEEECLEQEDLSLEDIHRPVLGEPEIHQTPDWEIVFEDNPGRLNERRFGTNISQVNSFVNLRETTPVHPLLGRHHDCSVCGKSFTCNSHLVRHLRTHTGEKPYKCMECGKSYTRSSHLARHQKVHKMNAPYKYPLNRKNLEETSPVTQAERTPSVEKPYRCDDCGKHFRWTSDLVRHQRTHTGEKPFFCTICGKSFSQKSVLTTHQRIHLGGKPYLCGECGEDFSEHRRYLAHRKTHAAEELYLCSECGRCFTHSAAFAKHLRGHASVRPCRCNECGKSFSRRDHLVRHQRTHTGEKPFTCPTCGKSFSRGYHLIRHQRTHSEKTS
The following text describes a protein:
Function:
Associates with spermatozoa in the epididymal fluid but does not bind tightly to them. Binds both all-trans and 9-cis retinoic acid. May act as a retinoid carrier protein which is required for epididymal function and/or sperm maturation.
Subcellular Localization:
Secreted. Note=Synthesized in the proximal part of the epididymis and secreted into the epididymal fluid.
Sequence:
MENIMPFALLGLCVGLAAGTEGAVVKDFDISKFLGFWYEIAFASKMGTPGLAHKEEKMGAMVVELKENLLALTTTYYSEDHCVLEKVTATEGDGPAKFQVTRLSGKKEVVVEATDYLTYAIIDITSLVAGAVHRTMKLYSRSLDDNGEALYNFRKITSDHGFSETDLYILKHDLTCVKVLQSAAESRP
The following text describes a protein:
Function:
Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins are not required to initiate repression, but to maintain it during later stages of development.
Subcellular Localization:
Nucleus.
Sequence:
MSEDQSVLGRRRIYYDASCGEALICSDSEEEGIDDEEEKKEFKHSEDCIIRMTVQECGMSDAVLHTLAQHLDRATDDIKARYEILQGEKTQDSCKKVIEHNAKVEDLYGDKDLDAALDSFDNLFCRRCLVFDCKLHGCSQDLVFPTEKQPACSGIADGASCGKYCYKASEPDSVAGIDHMLIDGEEPSHSSGNAMNQPGTNRKKNGSSGRKTKSQQSETSSTAMAVSESSDSEVHPISNKSPQPSPSPSKVKIGPKGGIRKITNRRIAERILMSVKKGQREMASSDSNSVSGSPLARDMKLRSNTRNGNKESFVSSQQNSPSTRSTRKKSTPQIGNSSASAEAQNDSMEEDGYDSSRKEEFVDENICKQEDSFRSWKPIEQGLLVKGLEIFGRNSCLIARNLLGGMKTCRDVFQYMNYIENSSASGTLSVVDSLVKGYIKGNELRTRSRFFRRRGKVRRLKYTWKSAGYHSIRKRITERKDQPCRQYNPCGCQSACGKQCPCLTNATCCEKYCGCSKICKNRFRGCHCAKSQCRSRQCPCFAADRECDPDVCRNCWVGCGDGTLGVPNQRGDNYECRNMKLLLKQQQRVLLGRSDVSGWGAFLKNSVNKHEYLGEYTGELISHKEADKRGKIYDRENSSFLFNLNNEFVLDAYRMGDKLKFANHSPDPNCYAKVIMVAGDHRVGIFAKERILAGEELFYDYRYEPDRAPAWARKPEDSRGKDDGQPSNGRAKKLAQNTRG
The following text describes a protein:
Function:
Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Miscellaneous:
MISCELLANEOUS: Present with 1100 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MMKRLHPLRIQVHLKSDYPLFTFEQLLSTNGIRRGQTARISLKDYIEWQNFPNIMKRENFFTQRKPVTTTAKEEPFSFDNILDCEPQFSKCLAKWLLVNYKLNDYPYYDLNIVNIYTDLPQAIQICKNLMSYLKSTLSDNMFQKIKYFMVPLYKCDKIPSKLLDGIPGSVSLVQDYPVSPYFLQKKFHIEDPIQILMLNDVIKYTTHDLVRYSSDDKGWQQCFVDINKNGQKSKSFDSAIDYSCELALEQMFNDRSHVSPGKELYIPTKLIEILMTIKNNIPEHRLFIVDTPQRSSPTIISLLKSLISPRPTGSSQIVQPYSDSIFSDKRSGRICFMTDFLQLQNIYNGINSSSSSCEVEDVADFVEKWISPSERSTLSSQNGNRPQLEDIKNSSLAVLHST
The following text describes a protein:
Function:
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MDQEIVAHIVLLVIVTLLSVIQNVFFAHKVEEENKNRTGKTAQRVSSAAFERIFNANQNCKDAYPTFLALLWCAGLLCSQAPAAFSGLMYLYVRQKYFVGYMGERTQSIPGYMLGKRLILFLFLMSVAGVLNYYLVVFLGSDFQMYIKTVSNTISPLLLIP
The following text describes a protein:
Function:
Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I interferon signaling pathway by interacting with host STAT1 and STAT2 and thereby inhibiting their phosphorylation and subsequent nuclear translocation. Efficiently blocks the type II interferon signaling pathway. Suppresses interferon induction by interacting with and stabilizing host UBXN1, a negative regulator of both RIG-I-like receptors (RLR) and NF-kappa-B pathways. Blocks the type I interferon signaling pathway by disrupting the RIG-I signaling pathway (By similarity).
Miscellaneous:
MISCELLANEOUS: The P/V/C gene has two overlapping open reading frames. One encodes the P/V/W proteins and the other the C protein.
Subcellular Localization:
Host cytoplasm.
Sequence:
MDKLELVNDGLNIIDFIQKNQKEIQKTYGRSSIQQPSIKDQTKAWEDFLQCTSGESEQVEGGMSKDDGDVERRNLEDLSSTSPTDGTIGKRVSNTRDWAEGSDDIQLDPVVTDVVYHDHGGECTGYGFTSSPERGWSDYTSGANNGNVCLVSDAKMLSYAPEIAVSKEDRETDLVHLENKLSTTGLNPTAVPFTLRNLSDPAKDSPVIAEHYYGLGVKEQNVGPQTSRNVNLDSIKLYTSDDEEADQLEFEDEFAGSSSEVIVGISPEDEEPSSVGGKPNESIGRTIEGQSIRDNLQAKDNKSTDVPGAGPKDSAVKEEPPQKRLPMLAEEFECSGSEDPIIRELLKENSLINCQQGKDAQPPYHWSIERSISPDKTEIVNGAVQTADRQRPGTPMPKSRGIPIKKGHRREISICWDGKRAWVEEWCNPACSRITPLPRRQECQCGECPTECFHCG
The following text describes a protein:
Function:
Necessary for normal cell division and for the maintenance of normal septation.
Sequence:
MNEDPQKKDEPFFKDVEFKASYGKADQIPSQGTPQIAFAGRSNAGKSSLLNAILERKSLAKVSSTPGKTKLLNFFFVNHSIYLVDLPGFGYSANSHKDHEAMMGLLMDYLNLAKDLKCLFLVCDSQRELPEEELELIGTCFERNIKPVLVRTKIDKLNQSDLSKLRKKMKNIHELYPMLETVLVSNKSGKGLPELRKIVYSLIETVKNRLERIEEIS
The following text describes a protein:
Function:
E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
Sequence:
MTVSVTLPALGESVTEGTVTRWLKQVGDRVEADEPLLEVSTDKVDTEIPSPAAGVLLEILAAEDETVEVGAGLGIIGAPDTAPAAPAAPAAPAPAPAPTPTPTPTPTPTASAPAPTPAPAPAPAPAPAPAEPFVPPAASAVPAPPAPAPAPTTPQAPAPAPAPVRAAPAEDASSLRGRTVAMTRIRRAIGNNLKKALLEQAQLTSTVEADVTRLMRLRNRAKDGFLAREGLKLSPMPFFVKAAAQALKAHPVVNARINEDEGTITYFDSENIGIAVDTEAGLMTPVVKAAGDLTVAGLARAVHDLADRARGGHLTPDDVSGATFTISNTGSRGALFDTVIVPPNQAAILGVGATVRRPGVVRVGDEEVIGVRDLVHLSLSYDHRLVDGADAARYLTAVKALLESAAFEDDLYPDAAA
The following text describes a protein:
Function:
Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. Involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MTQDRPLLAVQEALKKCFPVVEEQQGLWQSALRDCQPLLSSLSNLAEQLQAAQNLRFEDVPALRAFPDLKERLRRKQLVAGDIVLDKLGERLAILLKVRDMVSSHVERVFQIYEQHADTVGIDAVLQPSAVSPSVADMLEWLQDIERHYRKSYLKRKYLLSSIQWGDLANIQALPKAWDRISKDEHQDLVQDILLNVSFFLEE
The following text describes a protein:
Function:
Involved in innate cell-autonomous resistance to intracellular pathogens, such as Toxoplasma gondii. During avirulent type II T.gondii infection, recruited to the parasitophorous vacuole (PV) membrane, leading to PV vesiculation and rupture, and subsequent digestion of the parasite within the cytosol. Not recruited to virulent type I T.gondii PV membrane. May confer an antiviral state for vesicular stomatitis virus.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum. Golgi apparatus. Note=In astrocytes stimulated with IFNG or TNF, diffuse cytoplasmic localization decreases and the protein partially relocalizes to the endoplasmic reticulum and Golgi apparatus. Due to sequence similarity with Tgtp2, it is impossible to assign unambiguously experimental data published in the literature to Tgtp1 or Tgtp2 gene (Probable); Parasitophorous vacuole membrane; Peripheral membrane protein. Note=(Microbial infection).
Sequence:
MAWASSFDAFFKNFKRESKIISEYDITLIMTYIEENKLQKAVSVIEKVLRDIESAPLHIAVTGETGAGKSTFINTLRGVGHEEKGAAPTGAIETTMKRTPYPHPKLPNVTIWDLPGIGTTNFTPQNYLTEMKFGEYDFFIIISATRFKENDAQLAKAIAQMGMNFYFVRTKIDSDLDNEQKFKPKSFNKEEVLKNIKDYCSNHLQESLDSEPPVFLVSNVDISKYDFPKLETKLLQDLPAHKRHVFSLSLQSLTEATINYKRDSLKQKVFLEAMKAGALATIPLGGMISDILENLDETFNLYRSYFGLDDASLENIAQDLNMSVDDFKVHLRFPHLFAEHNDESLEDKLFKYIKHISSVTGGPVAAVTYYRMAYYLQNLFLDTAANDAIALLNSKALFEKKVGPYISEPPEYWEA
The following text describes a protein:
Function:
May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MGFLSPIYVIFFFFGVKVHCQYETYQWDEDYDQEPDDDYQTGFPFRQNVDYGVPFHQYTLGCVSECFCPTNFPSSMYCDNRKLKTIPNIPMHIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNNLEEFPFPLPKSLERLLLGYNEISKLQTNAMEGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLNLCNNRLESMPPGLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPYNIFNLPNIVELSVGHNKLKQAFYIPRNLEHLYLQNNEIEKMNLTVMCPSIDPLHYHHLTYIRVDQNKLKEPISSYIFFCFPHIHTIYYGEQRSTNGQTIQLKTQVFRRFQDDDDESEDHDDPDNAHESPEQEGAEGHFDLHYYENQE
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MQDGPIMSGISDFYRDKVVFVTGGTGFIGKIVVEKLLRTCEVKEVILMVREKKNTLPEQRIKTLCASPIFERLAKKNPNYQERIRVIEGDLEKPNFDLCPESMDYLKEHTHVILHIAATVKFDEEMIKAITINLAGTRTALEIGRQSKNLQSFVYVSTAYSNSYDEHIQERVYPIDCNPEKILANLDDEKLIQDVIQYSLKWPNTYTFTKAMAEALALEYRQHFPVAILRPSCVMASLNEPLPGWCDSIYGSNGTFIGWYYGLIRTSHIDPEVTIDTVPVDYVSNAIIAVGWKTYMERAQEPEVLVYNCVSSTDNPLTFDERRRECEKACKKHPLLTGIYKPITFASSNEIMFRLYSLVLHYLPAYIMDMALRFRGEKPRLVDTYVKIDKVVASVRKFSNTTYLFDNQNMKDLYLAMSPVDHQQYPCDNRNYSWRLYFEVAVPGLKKYFFKEDLNNVKRARQAMRKKELIVNTTLFLIVGLMLLQLYYLLR
The following text describes a protein:
Function:
Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes at both PRC2/EZH2 sites (H3K27me3) and broad H3K4me3 sites on chromatin of embryonic stem cells (ESCs).
Domain:
The BC-box, which mediates binding to the elongin BC complex.
Sequence:
METLCPAPRLAVPASPRGSPCSPTPRKPCRGTQEFSPLCLRALAFCALAKPRASSLGPGPGELAARSPVLRGPQAPLRPGGWAPDGLKHLWAPTGRPGVPNTAAGEDADVAACPRRGEEEEGGGGFPHFGVRSCAPPGRCPAPPHPRESTTSFASAPPRPAPGLEPQRGPAASPPQEPSSRPPSPPAGLSTEPAGPGTAPRPFLPGQPAEVDGNPPPAAPEAPAASPSTASPAPAAPGDLRQEHFDRLIRRSKLWCYAKGFALDTPSLRRGPERPPAKGPARGAAKKRRLPAPPPRTAQPRRPAPTLPTTSTFSLLNCFPCPPALVVGEDGDLKPASSLRLQGDSKPPPAHPLWRWQMGGPAVPEPPGLKFWGINMDES