lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. It is required for proper accomplishment of various processes including the regulation of endosome size, primary cilium organization, mitotic spindle organization and chromosome segregation, and nuclear envelope sealing and spindle disassembly during anaphase (By similarity). In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Critical for normal erythroblast cytokinesis and correct erythropoiesis (By similarity).
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein. Midbody. Cytoplasm, cytoskeleton, spindle. Note=Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells, interaction with ZFYVE19/ANCHR mediates retention at midbody. Localized in two distinct rings on either side of the Flemming body (By similarity).
Domain:
The MIT domain serves as an adapter for ESCRT-III proteins. It forms an asymmetric three-helix bundle that binds amphipathic MIM (MIT interacting motif) helices along the groove between MIT helices 2 and 3 present in a subset of ESCRT-III proteins thus establishing the canonical MIM-MIT interaction. In an extended conformation along the groove between helices 1 and 3, also binds to a type-2 MIT interacting motif (MIM2) (By similarity).
Sequence:
MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCMQYLDRAEKLKDYLRNKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSVMIDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQES
The following text describes a protein:
Function:
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
Subcellular Localization:
Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity).
Domain:
The C-terminal cytoplasmic tail controls its phosphorylation, stability, intracellular trafficking itinerary, and chemokine scavenging properties.
Sequence:
MPTVASPLPLTTVGSENSSSIYDYDYLDDMTILVCRKDEVLSFGRVFLPVVYSLIFVLGLAGNLLLLVVLLHSAPRRRTMELYLLNLAVSNLLFVVTMPFWAISVAWHWVFGSFLCKVISTLYSINFYCGIFFITCMSLDKYLEIVHAQPLHRPKAQFRNLLLIVMVWITSLAISVPEMVFVQIHQTLDGVWHCYADFGGHATIWKLYLRFQLNLLGFLLPLLAMIFFYSRIGCVLVRLRPPGQGRALRMAAALVIVFFMLWFPYNLTLFLHSLLDLHVFGNCEISHRLDYTLQVTESLAFSHCCFTPVLYAFCSHRFRRYLKAFLSVMLRWHQAPGTPSSNHSESSRVTAQEDVVSMNDLGERQSEDSLNKGEMGNT
The following text describes a protein:
Function:
May act as a lysosomal receptor (By similarity). May be involved in macropinocytosis and fluid phase exocytosis. Binds to the anionic phospholipid phosphoinositol 4,5-bisphosphate, but not to phosphatidylcholine and only weakly to phosphatidylserine.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Note=Localizes to membranes of endolysosomal vesicles and macropinosomes.
Sequence:
MVKRGCCHRKMVNHKGCLVSGIFLAVIGAVLFILAFALLPHLINQTTQNAVIQAVIVDSTSSQRYNDWAGQQSIENYYQQYFYAWNLTNPNEFLNGSIPIFETVGPFNYKYEFNFSNVTFQDGGNLATYTQSKSFIYQSDMSPNDPNEIMITNINPAYLGLMFQLAPNAELLDNMPAENLLIALSGCGQMRLFLEYLSSDNFTNIVYFTQNPKLYQEQYLNILKSLNGDEQYFYQQWANATSIPQKGNGWYGMLVSSVNNNNESSNISILSAKLLFNSSNENSILNQEIGSTLWINALLGDKTSITVLTSELQLTVDQIDMILNWWLNDFSKVYTESYVNEICDIPDISMLGVCQFVTGNALNGRSISNYTFLTQPFDQGPIEIPLLYQSIGIDVKLSVSVQQAYKSLFNESDSNSILNLNGLVNFLTASKSFDTFKQYNVTLFDAIKIIGYATAELYEQYNKPTILGLYEKYGGLIVTRSMDDWLWNCQDGILDYLGVDQPCALQQNNTVNKPSTIFTGQQDLSMTNQIFEFQEQTFLTCWNGSVQVEGFTESGQFPPLQSDPPQTMTLFEENVIRPVQLELSGDSQVQGIDTKRYYLVNNSFPISTTFKTTIPGFANLTDIQNLPIYVSLWDMYEVPPQYSSNNLQGLNQTYQSAQVPLDLEPITGNALYYNLKLQINLAIPEFSNWFSSNSTFKNMKSNVFYPILKIGQTATPSQSNIDLLNSQFKLIKILGFVPVIVVSIIGGIILIAGISMFAFGFKKLRQQKQQGYQAIINNE
The following text describes a protein:
Function:
Participates in transcription elongation, termination and antitermination.
Sequence:
MFKWYVVQVFTAQEKKVKKSLEDFKEASGMSDFIQQIILPSENVMEVKKGEHKIVEKYIWPGYLLVKMHLTDESWSYVKKTQGVVEFLGGGAPVALSEEEVKNILADLEEKKSGVVQKHKFEVGSQVKINDGVFVNFVGVVSEVFHDKGRLSVMVSIFGRETRVDDLEFWQVEEVVPGQESE
The following text describes a protein:
Function:
Involved in nucleocytoplasmic trafficking. May have regulatory roles in the gibberellin pathway, in auxin signaling and in light perception.
Subcellular Localization:
Nucleus envelope. Nucleus, nuclear pore complex.
Domain:
Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.
Sequence:
MSFFPPQQQQTPQPLFQTQQTSLFQPQQTNSIFSQSQPQQTNSIFSQSQPQQTNSIFSQPQQQQQTSLFQPQQFQQQQQQLNQQQQQQVQQQLYLFTNDKAPANYSTKWADLHPDSQKLLLQIEEKILEHRSESQRLDQCSRLYDSSVSSEGFEFDASRIVQELGGINTAMDRQKAVLHELMIVAKDMLRNAEIAVRSFMMLQPRFPHWKQGGGVVSVGSQPSQGQGTNPAPASSGQQQAVTTTVQVSDFYRGIPKKPTAFLLQTVVRFEKYLNECRQWVEELEQLLALDSDKYSRHASLLESLPKVMSNVHDFFVHVAAKVESIHQYIESMRTSYLADQRRRGECHDPFLEADRRETAKQEAAAKRVHPTLHLPASTTSTQPSTQVAGLIASSATPGGSNPPQTSVPTSNPSSGAGFSFLNTPASGPSSSLFATPSSTAPTSSLFGPSPTPTQTPLFGSSPASTFGSTQSLFGQTTPSLTMPSQFGGATPGSGASFGSMTKSSRPKSRTTRR
The following text describes a protein:
Function:
Modulates blood feeding of female mosquitoes on vertebrate species by binding and sequestering different mediators involved in the host response (By similarity). Binds leukotriene C4 and U-46619, a stable analog of thromboxane A2. Inhibits agonist-induced platelet aggregation. Exhibits vasodilating activity.
Subcellular Localization:
Secreted.
Sequence:
MIVTGVLLFILLELFAQGSQAFKALDPEEAWYVYERCHEDHLPSGPNRETYLKTWKFWKLEPNDAVTHCYVKCTLAGLQMYDEKTNTFKPETVPVQHEAYKSFTEVESSKVNELQQALSSLNAGSGSCAEVFNAYLPVHNKYVGVSRKIYHGTVDSVAKIYEAKPEIKKQEESFFAYCAKKALGANGKEGYTKLRDYELADSAEFRNAMDCVFRGFRYMDDSGLKVDEVVRDFNLINKSDLEPEVRSVLASCTGTQAYDYYSCLLNSPVKEDFRNAFYFHELRSANYGYLAMGKVYEGPEKVKEELKKLNY
The following text describes a protein:
Function:
Required for vacuolar assembly and vacuolar traffic.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network. Late endosome. Vacuole.
Sequence:
MEDDCHDDEEPRLKYQRLVGTLSDVLKKDAVSCMGVSDRFLAVGTHWGVVHIMDLIGTQVKRFQSHTATVNQVSIDDSGEFVASASDDGNVVINSLYTSDIQTYNFWRPVKAVSLEPDYSRKQTRQFVSGGMAGSLVLTGKGWFGNTNVAIHSGDGPIFHATWHGKYILWASETGVNIYDTVTSQRFGRIERPQDSPRADLFRCSICWKSDTTILVGWADSVKVIEIKERSKHDVASGLSPKYVDVVYQFRTDFIVSGISPLGDALVLLGYITDLSPLRDVDVLNPDIAHQKAQPPEMHIVDLEGEAVANDVLSLIGYEHFQANDYLLVYLASETETDASYYIVSPKDIVLARPRDIDDHIQWLVERQQYAEALCAADAAGSEYAGQSKVNTILDIGQKYMATLMADGNYLEAAQSCQKLLRTDQQLWEHWVHVFAAAKQLHIITPFVPLELPQLSSSVYDLILLNYLANDLDGLLQIIQLWSHDLYNIPVIINAVHSAFIRSPESVILIKIMLELYERNRQWDMVLYYGLCIHKPGVLDLVQKHNLFQTIELNALLVLQYDKHFIDAPGFQIPAFLEAMYIPESTSPPFQVVQQLQGHSRFLHVYLDALFINDSQESHTFHTLQVELYAEYDYARLMWFLRHSKFYSIPKAFDVCEARDLVPEMVLLLGKMGDSRRALMLIIERLRDAIEFTKDQNDEELWEEFLKYSMDKPAFIVGLLENLSAHIDPLRVIRLIPKGLRIPGLKNALIKIMTDCSVQKSLREGCEEVLVGDTWESTQNLYRQQRRGMRIQENGQCAICGGNTTNLGSLSSVTGIDSTPDLIVFFCHHQFHESCLDMDASTTNLQQKRSIHPHEAASMTARTKSTMAHTDRAIQSIYVRSNGHRIPAPLIPLAYAPTSYKPGLICPICRSSKRDAMQSV
The following text describes a protein:
Function:
During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes.
Sequence:
MQLNITGHNVEITEALREFVTTKFAKLEQYFERINQVYVVLKVEKVTHISDATLHVNGGEIHASAEGQDMYAAIDGLIDKLARQLTRHKDKLKQH
The following text describes a protein:
Function:
Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). Erg12 converts mevalonate into 5-phosphomevalonate (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase erg12 (AFUA_4G07780) first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase erg8 (AFUA_5G10680). The diphosphomevalonate decarboxylase mvd1 (AFUA_4G07130) then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase idi1 (AFUA_6G11160) then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase erg20 (AFUA_5G02450) catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGNPRGRRTNGSIKTSKGTQRGTVSNLLSDQPLAARPKVSIVSNDDSQDSSDGGAFTTPSTTESTLKTTINGTDSTERNMSRKPSSPMAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTLSKSQRTITMNFRDIGLDHTWNIDELPWDVFHHPSKKKFYYDLVTSLDPELVAAIQPHADAVSPDKPEDVRKIHRRSASAFLYLFLSLGSSQNPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHPDQPPDEAEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYSKPPTVTPLLNFPELPLLLVDTRQSRSTAVEVAKVGKLKDEYPVVTDSILEAIDQVTLAAQQKIQEISTNGISYRTLEDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTKLTGAGGGGCAITLLRPDIKEEAVRELEEKLSAEGFVKYETTLGGDGIGVLWPAVLRNGTDEEGGEEIDQQKFENAVGTEGIERLVGVGVQEKREGWKFWKRSPRFS
The following text describes a protein:
Function:
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
MATPSLLDDLGEEVTGIVAPVSLCMAVTVLLVRLLNPEGVSSSNTVLIASIAYQEQASDSSGKKFGGALLNALIFVAVVAGMTVVLFLLFKYKCYKFIFAYMGFAVFNIFFFITGALFIQVMQVIDLHIDAFSLAYGLFNFSIVGTLGLLFMPIPLLSKQVYLIWVGIIVAYIFTFIPEWTAWVILCFMALYDIVAVLVPGGPLKALVELAIERQQELPALIYEARPAGGRPYVRGWGNRGQRGEGEEGGPEGPAGPDGPGGPAANGAVPAAPPNVVPSPHANGRGPRPVAEASSPAASLEMRQPTTRAVHGQGAAAGAGAVFDPYEAPGSPGGTGRRRAGGVSGGGWAQAATTRVAPAVGAGAADFTGQTQVQPMRLSMAGEADAAMEAQWQQQPQRRRQRSQGGGAGSGPRPVAEGREQGEWQPLPAAPEGGAAGAALRVRPGGPGLSEPVAADSGRSSPRSHTSMEPLLNQRAAAAAALDRDLKDFDGAAGPSSRGRVSNSSAGPQGREMRSLQPGAGASSGKGALDPYLRGPSGGGGVAAAGGAAGGDPPRLTNPGTMGVRAVAPAFDAERLAEAVRRNTLDGELPASEPPPQLAGAPPPDGHHPHHRGHGHHHDGGADGGGEGGGDLPDLPDSIKLGLGDFIFYSMLVGRAAMYDFMTVFAAYLAIIAGLGLTLLCLAVFQKALPALPFSIALGVAFYFLTRLTLEPFLIPLATNLAFF
The following text describes a protein:
Function:
Transcriptional repressor of the kip gene-containing operon.
Sequence:
MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMVSSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLIMRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTELISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIAGFEARFTEDRLPYLTEKVKDAALQISRKIGYT
The following text describes a protein:
Function:
Involved in post-replicative DNA-mismatch repair. Has a role towards base-base mispairs and insertion-deletion loops.
Subcellular Localization:
Nucleus.
Sequence:
MSVGNVGKQREKTKDSSAKTKQKTLFGFFSKIPNVKQEKSDSTLSSSSNHDSNHDTPADVDNSSNVNKNSSSPERELPTSPSHHANTEIDSSSSMLPPPSSDPFSSPLSSSLHRSSPKRPHDSLGEESPGKLLRTSVKQEPDSEEEIDSPTKKKSFKSLDTSIFQAEDQFRHPVSSKLENSELSEVDKPFIASRRSRKPVSYAESDEDEDFDDAPTKGSRHKRIVSDDESDDYVEPDHISEASSEASLPIDEVESMDEDVDGYSDHSVSVAAPIPKKESRKESSNSLYESYRLGSQIASPSPSVSGSASPTKSNKNGVLNREEKRRQRMEAFKKENNERYEWLLDVRDADQNRVGDPNYDPRTLYIPPSAWATFKPFEKQFWKIKKDLMDTVVFFQKGKFYELYENDAAIGHQVFSLKLTDRVNMKMVGIPEASFDYWASQFIAKGYRIARVDQLETALGKEIKDRQRTQKEEKVVQRGLTQVLTSGTLVDEAMLTSDLSTYCMAIKESLQSDNEEPSFGICFIDTSTGGFHMCEFTDDIHRTKLDTLLTQVRPKELILEKSKISQKSIRAIKYCVSSSSIWNFIKPYTEFWDNERVEREIIAGDYFKNGLEGAPKILKSYLSEKPLAISAFGALFWYLRQLKLDKDMCSMGNFDEYDASQQSTSLLMNGQTLKNLEIFSNSFDGGSEGTLFHLLCRCVTPFGKRLFHTWLCHPLRSGTAINARLDVVELIADNPVIRDTIWGFLHKLPDLERLISRVHAGRSKPADFVRVLEGFQRINSAFDQLREEFMEVAEGTLLGEIIQSAPNMKEELEAWTRAFNWQKASEEGVFEPEIGFEAEYDTSQKYQSELKNELYALLEQYKKQLRCSSLNFKNIGKEVYQVEVPSDVKVPVNWCKMSGTKKTNRYYNDELRKKIKKLLEAEELHLAIMSRMQEKFYIRFDSNYEQWLALIKYTASIDCFFSLSQAAAALGEPYCRPEIIEQKDGHLYFEELRHPCINASAASTFVPNDVVLGGESPNMIVLTGPNMAGKSTLLRQVCIAVIMAQLGCWVPAKRASITPMTSIYTRLGANDDIMSARSTFMVELSETKKILDECGPKSLVILDELGRGTSTYDGHAIAYAVLHHLVSNIGCLGFFSTHYQSLCVDFMHHRQVRLMQMAAAVDEKIRRVTFLYKLEDGICPKSYGMNVASMAGLPEKVIDAAEEKASELEQASASFINASDDIALMSDFLQVLRISKSIEPLTAVNIPLILDSFE
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MLAMLGLVAALLSYPTALSMAEASLISMPTEDVHRGHAPVVFLAESLTPDYYADSCPDVRGLVRSAVGEALQKDIALAAGLIRLFYHDCFPQVHMHTYISTSMCPETDSQGCDASILLAGAESELQMWPNRFLQRAAVQLIEDIRIKVHHACGPVVSCADIMALATHDAVLKLIEAFESRSLDVTDLVALSGAHTIGGAHCTSYADRFAGEANSNEFVRMLLHNCTTGDIRDKQDLDVTTPNKFDDKYFGNLEAGKGVLNSDMQLLHDPRAMELVKGIAENQWWFWNQFDTSIRKLGQLQGPQGNAGEVRTISCSVPNHKSSNVGEV
The following text describes a protein:
Function:
Contributes to the assembly of the acentrosomal spindle and phragmoplast microtubule arrays as part of the augmin complex. Regulates the association of gamma-tubulin with the spindle and phragmoplast microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, phragmoplast. Note=Preferentially localizes to microtubules minus ends.
Sequence:
MAAKQMEEIQKKLRLLSYPRANAPAQSLLFAGMERYALLEWLFFKLLGDKSPFSQQNLQGDAGVRDEETVRIQYLAEIAKFLGITPTVDIEAIQGHGTYEDRMEMLRNIVDLVEASLFSDNQEWSIDEQVAKDIQLIDAIAERQSLIFSEECKLFPADVQIQSIYPLPDVSELETKLSEQAKILSNLQQKVDDLAAKHAYNPDEEYTEVESQLRARLESFLETARAFNTIYTKEIRPWTHMMEVPQLHGFGPAANRLLEAYNMLLKFLGNLKNLRDSHAALSIGSSGTVAGEPSSVTRIVSDCEAALTVLNRDLGILSASIAREQGERL
The following text describes a protein:
Function:
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter.
Subcellular Localization:
Nucleus.
Sequence:
MHLCGGNGLLTQTDPKEQQRQLKKQKNRAAAQRSRQKHTDKADALHQQHESLEKDNLALRKEIQSLQAELAWWSRTLHVHERLCPMDCASCSAPGLLGCWDQAEGLLGPGPQGQHGCREQLELFQTPGSCYPAQPLSPGPQPHDSPSLLQCPLPSLSLGPAVVAEPPVQLSPSPLLFASHTGSSLQGSSSKLSALQPSLTAQTAPPQPLELEHPTRGKLGSSPDNPSSALGLARLQSREHKPALSAATWQGLVVDPSPHPLLAFPLLSSAQVHF
The following text describes a protein:
Function:
Plays an essential role in chain termination during de novo fatty acid synthesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAMATRPISGGQLLTDGSSCVCGNGPSVSGSGARDTFFGQRLTVQYPVRRPRKQETARVQMTVHPINSVRSLVTQWLHRKASAEPVNTAVFTPYSMLREKAPAIADLPPSLRNGVAVKERPMPKTEEEERGGNAWGGFDLHADMFKAGRFVDSGFVFRERFAIRCYEVDRNRTASIETIANLMQEVSANHAQAVGFSNDGFATSPLMRERGMIWVTTRIHIEMFRYPKWGDFVEFDTWFQDPGRVGGRRDWNIRDAASGDLIGCGTSKWVMMDQKTRKLAPKDEEVKAELLVYCPQPSKFAPVDKLAASMKICKLEQPPEHTKQNLQARRSDLDMNHHVNNVAYFESAGPCSGTRGVQPFAEAAGGPVRDQPRPHCLAEEADGEPERSLNGKRGIRVNDKCEHKKRQSCVWQRLQEFKTERGRGR
The following text describes a protein:
Function:
Catalyzes the phosphorylation of pantothenate the first step in CoA biosynthesis. May play a role in the physiological regulation of the intracellular CoA concentration. Functionally redudant with PANK1. The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'-phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein.
Sequence:
MAGLKEDPVLGIDDIIETSEDAEVRDKLREEGGQSDREMSPATGNSIHRSGSRPQLDLSKAAIQGNSEERDPTILLPNQSDDISHLALDIGGSLIKLVYFSRHEDRSINDKRKKTVKERLGISNGNRRSYPVLGGRLHFVKFETSKINECLDFISSKQLHRGGIDSHGWLFEAPVNDNAIIKATGGGAYKFADLFKERLGVSLDKEDEMDCLVAGANFLLKAIRHEAFTHMEGQKEFVQIDHNDLFPYLLVNIGSGVSMIKVDGDGKFERVSGTNVGGGTYWGLGRLLTKCKSFDELLELSQRGDNRTIDMLVGDIYGGMDYNKIGLSASTIASSFGKTISEKKELEDYRPEDISLSLLRMISYNIGQISYLNALRFGLKRIFFGGFFIRGHAYTMDTISFAVHFWSKGEAQAMFLRHEGFLGALGAFMSYEKHGLDDLMVHQLVERFPMGAPYTGGKIHGPPLGDLNEKISWMEKFVLKGTEITAPVPMAPPGTTGLGGFEVPSSKGGTLRSDASALNIGVLHLVPTLDVFPLLVDPKMYEPNTIDLSDHNELEYWFTVLSEHLPDLVDKAVASEGGTDDAKRRGDAFARAFSAHLARLMEEPAAYGKLGLANLLELREECLREFHFVDAYRSIKQRENEASLAVLPDLLVELDSMTEETRLLTLIEGVLAANIFDWGSRACVDLYHKGTIIEIYRMSRNKMQRPWRVDDFDVFKERMLGAGDKKPHPHKRALLFVDNSGADVVLGMLPLARELLRRGTEVVLIANSLPALNDVTAMELPDIIAEAAKHCDILRKAAEAGGLIVDAMINTSDGSKENCSSVPLMVVENGCGSPCIDLRQVSSELAAAAKDADLIILEGMGRALHTNFNAGFTCDALKLAMVKNQRLAEKLVRGNIYDCVCRYEPAS
The following text describes a protein:
Function:
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).
Subcellular Localization:
Lysosome. Cell surface.
Sequence:
MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM
The following text describes a protein:
Function:
Likely activates multiple ubiquitin-like SAMPs for protein conjugation as well as for sulfur transfer, via ATP-dependent adenylation at their C-terminus. In fact, it is required for the formation of all three SAMP1-, SAMP2- and SAMP3-protein conjugates, and for molybdenum cofactor (MoCo) biosynthesis and thiolation of tRNAs.
Sequence:
MTLSLDATQLDRYSRHIIMDEVGPEGQGRLLSSRVVVVGAGGLGAPAIQYLAAVGVGELVVVDDDVVERSNLQRQVVHCDDDVGTPKAESAAAFVRGLNPDVSVEPVEARVDKSNVHEVVAGSDVVVDASDNFPTRYLLNDVCRFEGIPLVHGAIYKFEGQATTLVPDGPCYRCLFPEAPEPGTVPDCATTGVLGVLPGTVGCIQATEAMKLLLDEGEALDGRLLFYDAMDMTFETVPYRTNPDCPVCGEGGVDSIEDIDYVESCAISLD
The following text describes a protein:
Function:
Endoplasmic reticulum membrane-bound UDP-glucose:dolichyl-phosphate glucosyltransferase involved in protein N-linked glycosylation.
Miscellaneous:
MISCELLANEOUS: Present with 5800 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Its interaction with the substrate UDP-glucose may occur at the cytoplasmic side of the ER, whereas the steps utilizing dolichyl beta-D-glucosyl phosphate take place in the lumen of the ER.
Sequence:
MRALRFLIENRNTVFFTLLVALVLSLYLLVYLFSHTPRPPYPEELKYIAIDEKGHEVSRALPNLNEHQDDEEIFLSVVIPSYNETGRILLMLTDAISFLKEKYGSRWEIVIVDDGSTDNTTQYCLKICKEQFKLNYEQFRIIKFSQNRGKGGAVRQGFLHIRGKYGLFADADGASKFSDVEKLIDAISKIETSSTDLKTTKPAVAIGSRAHMVNTEAVIKRSMIRNCLMYGFHTLVFIFGIRSIKDTQCGFKLFNRAAILKIFPYLHTEGWIFDVEILILAIRKRIQIEEIPISWHEVDGSKMALAIDSIKMAKDLVIIRMAYLLGIYRDNKKC
The following text describes a protein:
Function:
In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.
Sequence:
MALTYQQSKLVRDTIPALKEHGERITSIFYKTMLTDHPELNNYFNSVNQKNGRQPRALTAVILGFASNINHLSELVPKFERMCNKHCSLGIQPEHYEVVGKYLIQAFGEVLGPAMTPEVQTAWTKAYWMLAKMLIGREAQLYRDFESWPSWRPFKIDRIVNECDDLYTFYLVPQDGKRLPKFLPGQYVSVQIQVPGGNLQSRQYSLSEAWREDYYRITIRRDEGTVYSNSVSKSFFNPGIVSNYLIDQTTVGSILQVSHPAGEFFLDVHNTSTVPLVLISAGVGVTPMVSIANTVMESQPSRQIAWIHGCRKHIPFEDHIKTLRKKNSNFQTKIFKTVINSTDRPGETYDYNERMDLAKLKPEELHLQHGGTEYFICGPEQFMVNQKLYLMQQGVSASRIKCEIFTTGDLSVVVQLPANDALAVRSTSTSTRLSSKSTIPTYQEAGSHNRDHRSGGGGWGRKEGDTYKQRRRGWMGKCGA
The following text describes a protein:
Function:
Required for efficient transcription initiation by RNA polymerase I.
Subcellular Localization:
Nucleus.
Sequence:
MPSIISSTNPQYINKCVNNGTMASSTNVPDRTVGSKSFASSVSKNDGRLMQQMLRAFVNKALDDKAEGNFAGYEDLRRQFAAKSDTKDAPSSLQLQNLLSALTCNVSRLDSSNSSLVMSVLDSVWVSRDESFVRCYTRFLGNLISAQSNYLPLVMTMLIQHMLYRPDSLAIHYEHAHMALKYVLELVPRAHSFLYSSILEEFPYKDESLLAQMTYISNVLSICEYVPSIKGPVLHAIIDKIIQIDVEIQVEVDDDDEEEDEVVTDDDGTSNADSEVITASTLYERHTAISSEMTSSTILTPPSLTDTRQLMQQLDQLLYTLFSYLDSNLKSTSRDRYLVYNSLIKSFVNTVLKTFRCRYTQFLIFWASQLDPEFTDIFLGVLTEVCLDPSQPYTLRLSGAMYIGSYVARAKALEKNTIQIIVNMMTRWVEAYLDQCENELSDDLLSKHSVFYAINQSIFYIFCFRWRELCVSDESESMEPRPNEWIPGLEILHRSVLSRLNPLRYCSPNIVLQFAKVANHLNFMYVYSIIEQNRKGIFREGFDTMDAYFPFDPYRLTKSSIIVQPFYNEWQQIPGLDDDEEEEDTDYESSTVMLGESPF