lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Magnesium transporter that mediates the influx/efflux of magnesium in a concentration-dependent manner. Plays a crucial role in male gametophyte development and male fertility.
Miscellaneous:
MISCELLANEOUS: Has the ability to complement mutants in Salmonella typhimurium and yeast lacking magnesium transport capability.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MGSLRRSTSNRSRKKGTAVKMNRMPSSLSPPTPPCSAIVGGTGKSKKRRGGVCLWTRFDRTGFMEVAGCDKSTIIERSSVSAKDLRTAFSHSSKILAREKAIVLNLEVIKAVITSEQVMLLDSLRPEVLTLTDRLKHHFPRKDGPENILQASSHGHQEGGEEGLKSKLPFEFRVLEIAFEVFCSFVDSNVVDLETQAWSILDELTKKVSNENLKDLRSLKTSLTHLLARVQKVRDEIEHFLDDKEDMEDLYLTRKWIQNQQTEAASNSIVSQPNLQRHTSNRISTSMVTEEDDIDDMEMLLEAYFMQLEGMRNKILLMKEHIDSTEAYVKILQNSRRNGLIHLMMLVNIGNYAITAGTVVVNLFGMNIPIGLYSTPDIFGYVVWAVVALCIVLFIVTVGYAKWKKLLD
The following text describes a protein:
Function:
May promote appropriate targeting of ribosome-nascent polypeptide complexes.
Sequence:
MLLVNIKLSDHKAGADNSSKQSRSEKMSRKATMKLGMKPVTGASKITIKRTKTSFVILTNKALYKLYISVIYGIYDKGGVLEGKNRGFELPAAQQFRIPDLSNMAAKVYLLSGAPTGEDEEEIDESGLEPRDIGLVMTQAGVSRAKAVKALKTNNGAHHLAMQIN
The following text describes a protein:
Function:
Phosphatidylserine receptor which enhances the engulfment of apoptotic cells. Also mediates the binding and engulfment of Gram-negative bacteria. Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity. In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells. Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner. Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma; [Vasculostatin-120]: Inhibits angiogenesis in a CD36-dependent manner; [Vasculostatin-40]: Inhibits angiogenesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, phagocytic cup. Cell junction, focal adhesion. Cell projection, dendritic spine. Postsynaptic density; [Vasculostatin-120]: Secreted; [Vasculostatin-40]: Secreted.
Domain:
The TSP type-1 repeats in the extracellular domain mediate binding to phosphatidylserine. They are also required for bacterial recognition and binding to bacterial outer membrane lipopolysaccharide.
Sequence:
MRGQAAAPGPVWILAPLLLLLLLLGRRARAAAGADAGPGPEPCATLVQGKFFGYFSAAAVFPANASRCSWTLRNPDPRRYTLYMKVAKAPVPCSGPGRVRTYQFDSFLESTRTYLGVESFDEVLRLCDPSAPLAFLQASKQFLQMRRQQPPQHDGLRPRAGPPGPTDDFSVEYLVVGNRNPSRAACQMLCRWLDACLAGSRSSHPCGIMQTPCACLGGEAGGPAAGPLAPRGDVCLRDAVAGGPENCLTSLTQDRGGHGATGGWKLWSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTSSRSQSLRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCPVDGKWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPEPHEICDEDNFGAVIWKETPAGEVAAVRCPRNATGLILRRCELDEEGIAYWEPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGEGVSEVIQTLVEISQDGTSYSGDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQILSNLLAEENRDKWEEAQLAGPNAKELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASGATDISFPMKGWRATGDWAKVPEDRVTVSKSVFSTGLTEADEASVFVVGTVLYRNLGSFLALQRNTTVLNSKVISVTVKPPPRSLRTPLEIEFAHMYNGTTNQTCILWDETDVPSSSAPPQLGPWSWRGCRTVPLDALRTRCLCDRLSTFAILAQLSADANMEKATLPSVTLIVGCGVSSLTLLMLVIIYVSVWRYIRSERSVILINFCLSIISSNALILIGQTQTRNKVVCTLVAAFLHFFFLSSFCWVLTEAWQSYMAVTGHLRNRLIRKRFLCLGWGLPALVVAISVGFTKAKGYSTMNYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKKLKERAGASLWSSCVVLPLLALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCRVVDRQEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSVLNKDIAACRTATITGTLKRPSLPEEEKLKLAHAKGPPTNFNSLPANVSKLHLHGSPRYPGGPLPDFPNHSLTLKRDKAPKSSFVGDGDIFKKLDSELSRAQEKALDTSYVILPTATATLRPKPKEEPKYSIHIDQMPQTRLIHLSTAPEASLPARSPPSRQPPSGGPPEAPPAQPPPPPPPPPPPPQQPLPPPPNLEPAPPSLGDPGEPAAHPGPSTGPSTKNENVATLSVSSLERRKSRYAELDFEKIMHTRKRHQDMFQDLNRKLQHAAEKDKEVLGPDSKPEKQQTPNKRPWESLRKAHGTPTWVKKELEPLQPSPLELRSVEWERSGATIPLVGQDIIDLQTEV
The following text describes a protein:
Function:
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
Subcellular Localization:
Cytoplasm.
Domain:
Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
Sequence:
MIVGLIGVVEKISALEVHIEVQGVVYGVQVSMRTAALLEAGQKARLKILQVIKEDAHLLYGFLEEGEKILFERLLKINGVGGRIALAILSSFSPNEFESIIATKEVKRLQQVPGIGKKLADKIMVDLIGFFIQDENRPARNEVFLALESLGFKSAEINQVLKTLKPNLSIEAAIKEALQQLRS
The following text describes a protein:
Function:
Involved in transcription repression and activation (By similarity). Required for larvae and pupal development, and for normal innate immune responses. Involved in modulating the activation of the immune deficiency pathway (Imd), acting either downstream of, or at the level of, the NF-kappa-B factor Rel. Possibly functions with akirin to regulate Rel, and its interaction with the Brahma complex protein Bap55 suggests that it may regulate the IMD pathway at the level of chromatin remodeling.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSADVRDILDMERANTPEVTRDSFLATKKRNFERTKTASRRPEGMHREVFALLYTDKKDAPPLLPTDTALGIGAGYKETKARLGMKKVRKWEWAPFSNPARNDSAVFHHWKRVTDNSTDYPFAKFNKQLEVPSYTMTEYNAHLRNNINNWSKVQTDHLFDLARRFDLRFIVMADRWNRQQHGTKTVEELKERYYEVVALLAKAKNQTSEKKVFVYDVEHERRRKEQLEKLFKRTTQQVEEENMLINEMKKIEARKKERERKTQDLQKLISQADQQNEHASNTPSTRKYEKKLHKKKVHQQPRPSRVDSVVNAIEIGSSGIKFADLRGSGVSLRSQRMKLPANIGQRKVKALEQAIQEFKVDPAPPPTEDICTSFNELRSDMVLLCELRTALSTCVYEMESLKHQYEAACPGKTLNIPPSLVPIKTEALDNSTN
The following text describes a protein:
Function:
Major transporter for myo-inositol.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGSSTNNTQSKATPSVLENEVNSSKSSVVSSTSSAKGLLRETTNHGTMETSSVQISESESRPSKMVLVLTLASSISGFMFGYDTGYISSALVQIGTDLSNKILTSGEKEFITSATSLGALLGAVVGGVLANLIGRRRVLLGSNIIFVVGTIIQLAARTVWTMIAGRFVLGWGVGIASLIAPLMISELAPAKYRGRLIVTNVIFITGGQLIAYFINWGLTRVSHGWRVSVGLCMVPPVLQFVLFWFLPDTPRFYVMNGNFEKARQVLRKVHVDPSDEFVNATIDEMIASDSTVPGNGPLQKAWKSIKIIHTTPGNFRALILACGLQGIQQFTGFNSLMYFSATIFETIGFHNATAVSIIIAATNFVFTGIAICIIDKVGRRRILLVGMPCMCISLIVCAVAFHYLNVDFSTGTVVSRGINGWGIVVIIGMILYVASYAIGIGNAAWVGVELFSDVNVRSIGAMYAACTNWAGSLVIASTFLTMLENITPTGTFSFFAGLCFIAFFFVYFLLPDTAGLELEETTDFLSNGFNVKQAAQLSKERKKHSKFAKSKPTV
The following text describes a protein:
Function:
Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.
Subcellular Localization:
Cytoplasm.
Sequence:
MASTTQIKTPQEAVARIAYLASDVVVSVQPSLAAESDFSATLKSLASSRTQSLVAKAADAVTEIIPVRHNNDPLLSVFTPIRSGRLVSVTTTSEVLLPSIAHLYKLAQLPVVLHVALGPKSLPDYTAITSIRNSGWTFLQSNSLQEAQDLALTAHALAVQSGKGVIHFFDPSSSASEQPIAAEDLSLVQEILNLDNVRRFQSASISGSSIYANDGRVAVVSEQSEPVASQTVLDARQVEAATATATDSLAPAQDGSDESAQTSQEQSEASEASATPSASVATTIDEQAPVVTSEHIYKYVTAIWAKLNDLAGRQYSAFEYSGPSNAENALFVFGSGSPLFAQAIAQAQSDDSFAKAGVLTARLYRPWLGAKLLEAIPKSVKRVAVLEQVSRKTTKWGPLLIDVLTSVKSGPGGVQTIVGHQLGYISQETVVQALRGIFQNLTSEKPVQNLEVGEREAPKEASEYGLEKPKLETAYTKILDQLFGERAYIANSIEKDNAGISNTISATPEYGFGALLARKERKQKFVSEVKEAASNGQFSSDAPKQALAKWVANAEDSKKVEEVASEAVSKLSEDGSDLSKSLLEYKQFFRKQSLWLVGSDAWSYDLGNSGVHHVLASGENVNLLIIDSTPYSERAAADANRRKKDIGLYAMNFGNAYVASTAVYSSYTQVLQAMDEADKFNGPSVVLAYLPYFGEHDSALTVLQETKKAVDIGYWPLYRWNPENEKKGEPSFSLDSERIKKELKEFLDRDNHLTQLMKKEPSFGAVLSEDFGTEIRAQQKRKAKDAYNQLLEGLFGAPLTILYASDNGNAISLSKRLGNRGRARGLKTTVMSMEDYPVEDLATEENIVFITSTAGQGEFPQNGLSFWHAVKDNTSLDLANVRYSVFGLGDSHYWPRKEDKIYYNKPAKDLDRVLANFGAKPLAPIGLGDDQDPDGFQTGYSEWEPKLWEALGVANVDGLPEEPAPRTNEDIKIESNYLRGTIVQGLNDTSTLAISPDDCQLTKFHGTYMQDDRDIRDERKAQGLEPAYSFMIRCRLPGGVSTAKQWVQMDDIANELGNETMKLTTRQTFQFHGVVKSKLKPAMQAINRALMTTIAACGDVNRNVMCSPLPAHSKYHRAVHACAKRISDHLLPNTTAYHEIWLTDDDGAKTQVGGNAVQDFEPLYGPTYLPRKFKVSIAIPPHNDVDVYAHDIGLIAIKNEDGSLAGFNLLAGGGMGATHNNKKTYPQTGRMLGFVTAADVHLACEKVMLVQRDNGDRKNRKHARLKYTIDDMGVDVFKAKVEEYWGQKFEEPRAFHFDSNVDTFGWTKDETGLNHFTMFIENGRIEDTAEFQMKTGLREIAKVHKGEFRLTPNQHLILSNVADEDKPELEKLLAQYKLDNLHHSGLRLSSSACVAFPTCGLAMAESERYLPVLITKLEGVLEEVGLKQDSIVMRMTGCPNGCARPWLAEVAFVGKAYGAYNMYLGGGYHGQRLNKLYRSSIKEEEILTIMKGLLRRYAKEREEGERFGDWTIRAGIIKATTDGRNFHEGVAEEEGDEE
The following text describes a protein:
Function:
Component of the elongator complex, a multiprotein complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSKFLLNRCIRDLSPLTVLKDNLQQTAKPILNYYAKNAASRGIKVLFISYETLEKEAPEGIDCFLYATSWEKVKSLKELYEHISSWRTQGKQHIVMIDTINPILNTSISSFTMFFGSVLALGSICFLTSFHKDVTLENYPSYLPPCEVFLDFTSTCTVSLIGMQHLSVEHDAKMRSLPNPLLEELQDDKIISLLGSNCETAIVLHVEFRKKSGRIIKESCVLKNGKLEPYTPFEETARGPEPADNQIDFNVSFNLNVSEKERKERDKVFLPYFSAQMVGSQHKSSFVDEGTIIYHADEADDFDEEEDADEDLLI
The following text describes a protein:
Function:
Plays an important role in the degradation of heme under conditions of iron deprivation.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MEDSSNTIIPSPTDVGALANRINFQTRDAHNKINTFMGIKMAIAMRHGFIYRQGILAYYYVFDAIEQEIDRLLNDPVTEEELQTSTILKQFWLEDFRRSTQIYKDLKLLYSNTFKSTESLNEFLATFQKPPLLQQFINNIHENIHKEPCTILSYCHVLYLALFAGGKLIRSNLYRRLGLFPNFEKLSQKELVKKGTNFFTFSDLGPTEETRLKWEYKKNYELATRTELTEAQKLQIISVAEGIFDWNFNIVAEIGELNRRELMGKFSFKCITYLYEEWMFNKDSATRRALHTVMLLVLSIIAIWVLYFLVKSFLSIV
The following text describes a protein:
Function:
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
Subcellular Localization:
Cytoplasm.
Sequence:
MLYRSWTSALFFTANNPSGEILKRRCLLHNLEAWIPLVSCVEVIQDYLTMHTVNNSILMFSRVNSFLKCSNYDRVACKVKDFKCFHSSVYQKIPFTALPLENKWHQKRHSFKTRPPNLPKDQVKEILTNLIGANNININNLKELPSYADRNYYFQLDYPIISRHFGNYQDSSVHTYSKMAKENQSYVLKILSCPDQESYDLHHARLCAMKHLYNTGINCPSPINLANQKWIKTVKLPQQKLNAGNQSMDNFEEHIAYLLTYVDGQTVATIQPNEDLLYQIGGYAGLLDKNLQNFSDDRLKVNRSIWSIHNFLELKPYIQYCREDKRDFMERIYDRCASYFQVNMNNLRINVIHNDLNIDNIIIKQNNGVTGYKVAGIIDFGEVDYAFTISELAIMVYYAMWIINQDPLTAAGHLIAGFNSVFPLTDIEYKGLYTMILARLFQSITLVDYHISCFPENEYLKGHYDKKLKIYDLLSCASERKVYKIWDEIMKIRKN
The following text describes a protein:
Function:
Involved in the presentation of foreign antigens to the immune system.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MVCLWLPRDPCVAAVVLSLLMLSPPVALVRDPRPRFLEQLKAECHYVKGREHVWSVTRFIYNQEEFARFDSVFGKFLAVTELGRPIAEYLNTQKDMLDNYRASVDRCRNNYDLVDIFMSNLKAKPKVTVYPSKTQPLEYHNLLVCSVSDFYPGTIEIRWFRNGEEEKTGVVSTDLISNGDWTYQTLVMLETVPQGGEVYTCQVEHPSLTSPVRVEWRARSTSAQNKMLSGAMGMALGLFILAVGLFIYLRNLRAGSVSHGAGEGAESSTSRLTGSRSECHTGPALSV
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MFAARFDPSRHYEEGDTAPPAPSLPMKRSRDAQQDESESEMSSAESEDEAMQLDDEEEVVDSKGKENHGSDSIGTGEADKRHQSVLSRFQRTISVQDKLDSDAIVGSDSEEEPAKMHGLVPIAQPAIVRDTLAQDSRKERKLLAWSNTTKIHYDSTMTKPFAAYKDILSTSLLANVEGGFSRTAFPIQTALLDSVLPLMSQAYSVSKRYYTRKVGDILVNASTGSGKTLAYAMLLIHILSRRTVNKLRAVILVPTKLLVHQVYDTVQALAKGSSVVVAVSKMDTSLKEESAKLKAQEPDVLIITPGRLVDHLNMQTFSLKNLKFLVLDEADRLLNQSFQNWCIELMTRLNAERPFKGPGNVIKMIFSATLTTNTERLHDLQLHNPKLFLMGSQLYHMPAQLQEYNLPIPTSKSYAKPLILLRLLPLLSTESLRILVFVKSNEASIRLAALLTAMVGNGLSAVSTTVGSINNNNSKATNRKLIEAFAAGASGHCSILVSTDLMSRGLDISGISHVINYDLPISSQQYVHRCGRTARANTSGTAVNLLVGKGEQNFWKDHIDSDISRAPDGSHLFFDEEQREQLVSLSEEDTATYKKCLEELKKSVLGR
The following text describes a protein:
Function:
Water channel probably required to promote glycerol permeability and water transport across cell membranes.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala/Gly (NPA).
Sequence:
MAEISGNGGDARDGAVVVNLKEEDEQQQQQQAIHKPLKKQDSLLSISVPFLQKLMAEVLGTYFLIFAGCAAVAVNTQHDKAVTLPGIAIVWGLTVMVLVYSLGHISGAHFNPAVTIAFASCGRFPLKQVPAYVISQVIGSTLAAATLRLLFGLDQDVCSGKHDVFVGTLPSGSNLQSFVIEFIITFYLMFVISGVATDNRAIGELAGLAVGSTVLLNVIIAGPVSGASMNPGRSLGPAMVYSCYRGLWIYIVSPIVGAVSGAWVYNMVRYTDKPLREITKSGSFLKTVRNGSSR
The following text describes a protein:
Function:
Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
Subcellular Localization:
Cytoplasm.
Sequence:
MAQPSLNHKVTLNRRALITGRVLSADRIVPPPGYEIASIIVQARPERLAEVEAEIIALAGCEIHGRDPRGKLVVVTEAPDAGSLGTMLNTIQSLQHVYSAALVFHAIETA
The following text describes a protein:
Function:
DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.
Subcellular Localization:
Nucleus.
Sequence:
MSLTPVSATTQEGQVSDGTGASGESKSDCPSNSRRPSLSEVILWAVAGSNIRRGVSLATLKKAVSNTGFNMVRNAQRFKRVLKGLVAKGVLKQVTGTGVSGSFRMGKKKPKSEKARRRPRQKRQRKQAPQVEQQQKAKGRQKKGARKPARRSRK
The following text describes a protein:
Function:
Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MARRMITIHSTSAADHTQGWWVDLCQPSAQQLAEAAKRVGFALPDRAAIGEIEFSSRVRHEGDVLFLNVPRFQDDDGPTAPLGFAVSAHMLVTQREQPMGSLDAVAARLAHAPCRGGDDLLLRIFDQLVGHLADRLEALEAEITETTRAVFDTSTKTKTGALERMLHQVGDMGRRLGGLHNAGQGLLRLVTYLDGAAPEWFGDDAARRIGLLHKDLTTLSEFQQHMDDRIEFLLDSVLGLINMEQNNVMKVMAVASVVGIPPTVLVGIWGMNFAHMPELKWHDAYYWALGVIALSVVVPLAWFRKRGWV
The following text describes a protein:
Function:
G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTPRRSRVKRRNLRKPKMRFLLVNRFTLLLLLLVSPTPVLQAPTNLTDSGLDQEPFLYLVGRKKLLDAQYKCYDRIHQLPSYEGEGLYCNRTWDGWMCWDDTPAGATAYQHCPDYFPDFDTAEKVSKYCDENGEWFRHPDSNRTWSNYTLCNAFTSEKLQNAYVLYYLALVGHSLSIAALVASMLIFWIFKNLSCQRVTLHKHMFLTYILNSIIIIIHLVEVVPNGDLVRRDPMHIFHHNTHMWTMQWELSPPLPLSAHEGKMDPHASEVISCKVLHFLHQYMMSCNYFWMLCEGIYLHTLIVMAVFTDEQRLRWYYLLGWGFPIVPTIIHAITRALYYNDNCWLSAETHLLYIIHGPVMVALVVNFFFLLNIVRVLVTKMRQTHEAESYMYLKAVKATMVLVPLLGIQFVVFPWRPSNKVLGKIYDYLMHSLIHFQGFFVATIYCFCNHEVQVTLKRQWTQFKIQWSQRWGRRRRPTNRVVSAPRAVAFAEPDGLPIYICHQEPRNPPISNNEGEESTEMIPMNVIQQDASA
The following text describes a protein:
Function:
Plays a central role in social feeding behavior and oxygen sensation by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which binds to its heme-binding sites, probably regulates social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in avoidance of hyperoxia and for oxygen-induced aggregation and bordering, probably by mediating oxygen-sensing in URX, AQR and PQR sensory neurons.
Miscellaneous:
MISCELLANEOUS: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.
Subcellular Localization:
Cytoplasm. Cell projection, dendrite. Note=Enriched localization at the URX dendrite ending.
Sequence:
MFGWIHESFRQLVTRKYGKDIWEKIVHMSKFELGTESEIAHYYNDDETLRLVNSMANVIGIPIEEIWEAYGGFLIQFTMETGWDELLRAMAPDLEGFLDSLDSLHYFIDHVVYKTKLRGPSFRCDVQADGTLLLHYYSKRSGLYPIVKGVVREVARRIYDTEVVMKVQERKQEHLDAFVTEHVVFVITQIENANSTQPKSISSKADSQIDLSTGIYEISSSDFSLAFPYHICFDPDLFVEHFGNFIKKTFPNAMRQETRVTDLLELVHPEVPFSYESIKYYKNSLFVFRLKGLGDIVHNANDEAKTVLLKGSMVFIDEGKYILYMCSVNVTTVRELIERNLHLSDMQRHDGTRDVIMLNQSRMSQVELNRTLEETTKKLKKMAQELEIEKQKTDELLCELMPASVADSLRSGKAMDAKEFADCTLLFTDIVTFTNICAMCTPYDVVTLLNDLYLRFDRLVGLHDAYKVETIGDAYMIVGGVPERCENHAERVLNISIGMLMESKLVLSPITHKPIKIRLGVHCGPVVAGVVGIKMPRYCLFGDTVNVANKMESNGIQCKIHVSETGKLNGLKANPSYVFIDRGNTEIRGKGMMYTYFLERNDRKSVWELCSRPRSGEQTIDGYMELHDQSIYQEEGGQQENLTVENGNSAQNNHNNNNNTHHSGRKLMNGSSVDPGSHHIRSPTCTIS
The following text describes a protein:
Function:
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Subcellular Localization:
Nucleus.
Sequence:
MRRGKIAPDGNEARKRSEKGDSKSLNAYFKQRKSRTEDFKCRDLEGENQKQIRESGNENKGKPGKGFFACYLLTSLSPRHKGHTYIGFTVNPLRRIRQHNGEIGSGAWRTKSRRPWEMVVCIYGFPTNVSALQFEWAWQHPRESEAVRQAAATFKSFSGVTNKIKLAYTMLTLPAWQSLNITINYFSTKYTNHSASCPSLPEQMKVKVSPMDELPCYTEPNEIEYKDDCDNLDEYDEVSDTCETVPETYPNEVVIVSADNLHSIIHEACHEQSEHIEEHGTRKPGESSNLGVGNVESLVFIDPPTSKATSIATGLTVVNAAECADMSIAGKESLRGMRFKYAVEADEDPQPSVKEVKEKPSTTDEEYEKLGDTCTFGVYHRQPFDVICSPVRASSSVFTSLSNEETAEGTNVSIIEKECRIQKQFSAFVAASGDQQSWRKEKPLTTEVAVLKEHVPSFDVTREPEVIDLLTPSPSYRVRPCTKKRRISKFSPEIIDLT
The following text describes a protein:
Function:
Initiates complement activation and/or interferes in platelet aggregation and/or blood coagulation.
Subcellular Localization:
Secreted.
Sequence:
MERGSFGEETEASCCAQLKGLLQCGTDKVFFQGQAGTPGIPGIPGTNGLPGMKGDPGPQGPPGERSSAGAPGKAGPKGEKGEQASRYVLSPLPQTTGAKDCKELLERGETLSGWYTIYPATGKTMSVFCDMETDGGGWLVFQRRQDGSVDFYRDWKSYKNGFGNQASEFWLGNDNIHLLTSSGTQQLRIDVKDFNNTRTYATYSSFKISSEKENYTLSVASYMDGNMGDSFSGHRGFAFSTRDKDNDIHETASCAVMFKGGWWYSKCHSSNLNGLYHRGEHTSYADGINWAAGKGHHYSYQYVDMKIRPQ
The following text describes a protein:
Function:
Transcription activator involved in xylem formation. Promotes the expression of the secondary wall-associated transcription factor MYB46. Functions upstream of NAC030/VND7, a master switch of xylem vessel differentiation. Acts as a upstream regulator of NAC101/VND6 and LBD30/ASL19.
Miscellaneous:
MISCELLANEOUS: Overexpression of NAC075 induces the formation of ectopic xylem vessel-like elements.
Subcellular Localization:
Nucleus.
Domain:
The NAC domain includes a DNA binding domain and a dimerization domain.
Sequence:
MNKSNPAGSVTGSDIIDAKIEEHQLCGSKKCPSCGHKLEGKPQDWVGLPAGVKFDPTDQELIEHLEAKVLAKDFKSHPLIDEFIPTIEGEDGICYTHPEKLPGVTRDGLSRHFFHRPSKAYTTGTRKRRKIQTECDNNLQGSSSSGETRWHKTGKTRPVMVNGKQKGCKKILVLYTNFGKNRKPEKTNWVMHQYHLGTHEEEKEGELVVSKIFYQTQPRQCNWSSSTSSLNAIGGGGGEASSGGGGGEYHMRRDSGTTSGGSCSSSREIINVNPPNRSDEIGGVGGGVMAVAAAAAAVAAGLPSYAMDQLSFVPFMKSFDEVARRETPQTGHATCEDVMAEQHRHRHQPSSSTSHHMAHDHHHHHHQQQQQRHHAFNISQPTHPISTIISPSTSLHHASINILDDNPYHVHRILLPNENYQTQQQLRQEGEEEHNDGKMGGRSASGLEELIMGCTSSTTHHDVKDGSSSMGNQQEAEWLKYSTFWPAPDSSDNQDHHG
The following text describes a protein:
Function:
Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit FdnG contains the formate oxidation site. Electrons are transferred from formate to menaquinone in the gamma subunit (FdnI), through the 4Fe-4S clusters in the beta subunit (FdnH). Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar).
Subcellular Localization:
Periplasm.
Sequence:
MDVSRRQFFKICAGGMAGTTVAALGFAPKQALAQARNYKLLRAKEIRNTCTYCSVGCGLLMYSLGDGAKNAREAIYHIEGDPDHPVSRGALCPKGAGLLDYVNSENRLRYPEYRAPGSDKWQRISWEEAFSRIAKLMKADRDANFIEKNEQGVTVNRWLSTGMLCASGASNETGMLTQKFARSLGMLAVDNQARVUHGPTVASLAPTFGRGAMTNHWVDIKNANVVMVMGGNAAEAHPVGFRWAMEAKNNNDATLIVVDPRFTRTASVADIYAPIRSGTDITFLSGVLRYLIENNKINAEYVKHYTNASLLVRDDFAFEDGLFSGYDAEKRQYDKSSWNYQLDENGYAKRDETLTHPRCVWNLLKEHVSRYTPDVVENICGTPKADFLKVCEVLASTSAPDRTTTFLYALGWTQHTVGAQNIRTMAMIQLLLGNMGMAGGGVNALRGHSNIQGLTDLGLLSTSLPGYLTLPSEKQVDLQSYLEANTPKATLADQVNYWSNYPKFFVSLMKSFYGDAAQKENNWGYDWLPKWDQTYDVIKYFNMMDEGKVTGYFCQGFNPVASFPDKNKVVSCLSKLKYMVVIDPLVTETSTFWQNHGESNDVDPASIQTEVFRLPSTCFAEEDGSIANSGRWLQWHWKGQDAPGEARNDGEILAGIYHHLRELYQSEGGKGVEPLMKMSWNYKQPHEPQSDEVAKENNGYALEDLYDANGVLIAKKGQLLSSFAHLRDDGTTASSCWIYTGSWTEQGNQMANRDNSDPSGLGNTLGWAWAWPLNRRVLYNRASADINGKPWDPKRMLIQWNGSKWTGNDIPDFGNAAPGTPTGPFIMQPEGMGRLFAINKMAEGPFPEHYEPIETPLGTNPLHPNVVSNPVVRLYEQDALRMGKKEQFPYVGTTYRLTEHFHTWTKHALLNAIAQPEQFVEISETLAAAKGINNGDRVTVSSKRGFIRAVAVVTRRLKPLNVNGQQVETVGIPIHWGFEGVARKGYIANTLTPNVGDANSQTPEYKAFLVNIEKA
The following text describes a protein:
Function:
Heterochromatin-binding protein that preferentially occupies long transposons and specifically recognizes the histone H3 'Lys-9' methylation (H3K9me) marks, with a stronger affinity for dimethylated H3K9 (H3K9me2). Required for transcriptional silencing, non-CG DNA methylation (e.g. CHG and CHH regions), and H3K9 dimethylation (H3K9me2) at some loci. Mediates heterochromatin phase separation and chromocenter formation.
Subcellular Localization:
Nucleus. Note=Enriched in heterochromatin, concentrated in centromeric and pericentromeric regions.
Domain:
The tandem Agenet domains (AGDs) mediate the specific recognition of the histone 3 lysine 9 dimethylation (H3K9me2) mark.
Sequence:
MLRPRRSLGVSSPAKQRKKAAPKNSMATRANRKRLPSYLKPGSAVEISSDEIGFRGSWYMGKVITIPSSSDKDSVKCQVEYTTLFFDKEGTKPLKEVVDMSQLRPPAPPMSEIEKKKKIVVGEEVDAFYNDGWWEGDVTEVLDDGKFSVFFRSSKEQIRFRKDELRFHREWVDGAWKPPLEETEEEEDESEEDKLDDSEDEEDILARVDLETTRAIAKQMFSSGTVVEVSSDEEGFQGCWFAAKVVEPVGEDKFLVEYRDLREKDGIEPLKEETDFLHIRPPPPRDEDIDFAVGDKINAFYNDGWWVGVVIDGMKHGTVGIYFRQSQEKMRFGRQGLRLHKDWVDGTWQLPLKGGKIKREKTVSCNRNVRPKKATEKQAFSIGTPIEVSPEEEGFEDSWFLAKLIEYRGKDKCLVEYDNLKAEDGKEPLREEVNVSRIRPLPLESVMVSPFERHDKVNALYNDGWWVGVIRKVLAKSSYLVLFKNTQELLKFHHSQLRLHQEWIDGKWITSFKSQKV
The following text describes a protein:
Function:
May be involved in protection from oxidative damage.
Subcellular Localization:
Mitochondrion.
Sequence:
MSSASQPDLSTPTTPATSTSSSGTDPPHLNSNDKKSSSSTSLHQSAASYFTYPVTHVVSGLYRRLTDPPTTNSANSTSNNMMSRLRRQNPNPNPNPSSSSSSISSSSQHPVFTPVRTVSPFQPPPLTPLTLLANEETTPIPLAPQNQLLSRALAEEIRLLVPPRLQLVNSWRLAYSLDRDGASLSTLYENCRSVSARSPRAGYVLVVRDASPSASTIFGAYMTDPPHPDSHYFGTGECFLWRASVLRPPPASLSMADGDGGVYSEEALERAGLPPPPSADTTNVGRSTTLRGEKAQPKSLAPHTHGLAQGGATNSGTTTPDRIRFKAFPYSGVNDYMMFCETGFLSLGGGSTVLGFTSAHHRFGYLISNALGRYGEMEANISKDDMLPRGIHY
The following text describes a protein:
Function:
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Subcellular Localization:
Nucleus.
Sequence:
MSDATVDTSSKIITKVLKEKKEVVEEAEKGRDGPGNGNEADNEVEEEYEEYGEEKEEEEGDGEEEDEDEDVAAEDAMGKWAVEDAEDDNVDTKKQKTDEDD
The following text describes a protein:
Function:
Shows aminotransferase activity with methionine and histidine as substrates, and to a lesser extent also with phenylalanine.
Subcellular Localization:
Cytoplasm.
Sequence:
MTNNPLIPQSKLPQLGTTIFTQMSALAQQHQAINLSQGFPDFDGPRYLQERLAHHVAQGANQYAPMTGVQALREAIAQKTERLYGYQPDADSDITVTAGATEALYAAITALVRNGDEVICFDPSYDSYAPAIALSGGIVKRMALQPPHFRVDWQEFAALLSERTRLVILNTPHNPSATVWQQADFAALWQAIAGHEIFVISDEVYEHINFSQQGHASVLAHPQLRERAVAVSSFGKTYHMTGWKVGYCVAPAPISAEIRKVHQYLTFSVNTPAQLALADMLRAEPEHYLALPDFYRQKRDILVNALNESRLEILPCEGTYFLLVDYSAVSTLDDVEFCQWLTQEHGVAAIPLSVFCADPFPHKLIRLCFAKKESTLLAAAERLRQL