lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
Subcellular Localization:
Zona pellucida. Cell membrane; Single-pass type I membrane protein.
Domain:
The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
Sequence:
MDTDFPNTYSCCVFSSFPCCISPSFHAVPLLLTTSCRFSSFAPAGLTPGGSAAAPETRETGEHSAEVYVVRCEADSVEVVVKAPPDDIGFFEESARPRLGLSRARDHCAARLSASGDYVIHVPLTECGSSMMVSGGLSNLLLLPLPSSAVDVEEAAIPVLCQYKRKYTVSSGELRPTWTPHISVQSTHLQLDFRLRLMTSDWSSERKFPVYFMGETVNMEASVDHPNPSLRLYVGSCVATLTPDVTSHPRYPFIDHRGCFTDSLLSGSRSRFLPRVQDQLLHIQLQPFLFHQDHRRNGESVFHRFEPNLLQGFQRDEAGFPDRWRSVDGEDSACESCSSPEEAHSSAAEHGHKRAQRSQWGHAHTVSSSPIKPLPSPSPPPPLPPLNACLDSFSYISICISFASHLRAIHSGQLPSAAFCVFAEGEPDRDLRLDTSHSGTLVLRLHTTAFRLQGQVKTL
The following text describes a protein:
Function:
Catalyzes the ATP-dependent formation of a covalent bond between the amino group of glutamate and the gamma-carboxyl group of the C-terminal glutamate residue in LysW.
Sequence:
MRVVLIVDIVRQEEKLIAKALEENKVQYDIINVAQEPLPFNKALGRYDVAIIRPVSMYRALYSSAVLEAAGVHTINSSDVINVCGDKILTYSKLYREGIPIPDSIIALSAEAALKAYEQRGFPLIDKPPIGSWGRLVSLIRDVFEGKTIIEHRELMGNSALKAHIVQEYIQYKGRDIRCIAIGEELLGCYARNIPPNEWRANVALGGTPSNIEVDEKLKETVVKAVSIVHGEFVSIDILEHPNKGYVVNELNDVPEFKGFMVATNINVAQKLVEYIKENYSK
The following text describes a protein:
Function:
Implicated in endocytosis. May recruit other proteins to membranes with high curvature.
Subcellular Localization:
Cell projection, podosome. Cytoplasm. Early endosome membrane; Peripheral membrane protein.
Sequence:
MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVAEVLARTIEYLQPNPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEIQHHLKKLEGRRLDFDYKKKRQGRIPDEELRQAMEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELADKLKRRMREGSSRPRREYKPKPREAFELGEPEQPNGGFPCATAPKVTGSSSFRSSDKPIRTPSRSMRSMAEGAALLGGSGEQGWGAASAPPAAGQVEARTLRPPPAPLDQPSCKALYDFEPENDGELGFREGDIITLTNQIDENWVPPPSTRSVSLGHELPPHRRPTRDHGAPASTLRRPSTKALRSQRPHTPGCWGRAGGGTWVPTPISSGPGRLLQTSRARPTPAFPLA
The following text describes a protein:
Function:
Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes. Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes.
Subcellular Localization:
Nucleus. Nucleus speckle. Note=Colocalizes with the spliceosomal components PRPF8 and SNRNP200/BRR2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. Colocalizes with RNF113A and 'Lys-63'-linked polyubiquitinated proteins, ALKBH3 and ASCC3 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage.
Domain:
The CUE domain specifically binds RPS20/uS10 ubiquitinated via 'Lys-63'-linked ubiquitin chains by ZNF598.
Sequence:
MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERATFVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLHRSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMIGNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLLELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLEDSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQEKRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVIEEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLPDLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVFQNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQPGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEEDDDDEEDDADEEAPKPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQSRETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
Subcellular Localization:
Cytoplasm.
Sequence:
MPVRIYALAKELNLDSKELVDVVKKAGITGKGSALASLSDEEAQQVRGHLAGSAAKSEPKPKAAPPTKDTPTAPVAPVRDLSGATGRKPSAINVGRPSKPAEAADNPNAPAQPIRDGGRPVGKPAPIVRTPKLAPAPEAKAPEAPAADGSPKPEIRLPKTGGVGTGMASPSGRGIGMGAKTDGQSTKPESAASAPSVPGPKSDSGGRKAPESPKRESAPVASSDDDGSSNKGGGLASRIAGRMGNNSSGRVVPNTPGTPLSAVRRDSASAGGKMRSLDRSRNRPEEAAKAGDAGKSKKREPRIKVNLAQLPSAPAKPAAPTGSSGPAAQKPDIKLTRDVIEGHKQGMKAPLARLEQDEADKKQRSKKTAEGTVGLAGRGKRVIDEDEKPKKKGLAGMASARAERQRGGGGRRIVGSDGGDRHHYRRSRPRIRRKGVNTAAPRKEKVQIELPCTVRNFCEGSGLSVADVMRTLMGMGMMVNINADIDFETAELLATEHDLDIELKAAESLEQELITEIEETADDPDTLVARPPVVTFLGHVDHGKTSLLDHLVGINVVKGEAGGITQHIRAYKIDKDGRAVTFVDTPGHEAFTEMRARGANVTDIAVLVVAADDGIMPQTEEAISHAKAAEVPIVVALNKIDLEGVDANRVMTQLTEHQLTPSEWGGDVEIVRTSATQGTGMDELLDTLLTIAELNEYSANPNRSALGVCLESEQQGDRGVVAKLIVQNGTLRVGDILVCGPAHGRVRAMQDTLTGKPITEAGPSTPVSLMGLDTPPGAGDRFHVLKDISQAREIASAREGESSRQSLSGITTKVSFDSFQEMLEDGKLGESADTVKLNLIIRADARGSLEAIDKELSKFDHPEVEIRVLQRSVGGISLADATLASASDAVILGFNVIPDDKARSLAEERGVEIRRYDVIYKLTDDIRALIEGRLKPEERVVELGRALVKQVFSISRVGTIAGCYVAQGSIQRNCRIRVNRDGRTIGDYQLDTLRRIKEDVKEVPRGMECGIRLQGFNDIKQDDVLEAYKIEEVARKLD
The following text describes a protein:
Function:
Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus membrane.
Sequence:
MTAGASQAGPDSFPREALLKDVRLFGRFTSCSALIVNVLLPHLTEDEVDGHRLTSELQQHLCTLEPTSCNISRPLVGPSRLSHLYEHDHAERDSERWILAFAYALMFLYIGFVVSRFHAVKSKVGLGIAVVSIVGSSTLTAVGVCQSLGLVPSFRAVELLPFLVMTIGLDNIITITECVEATASSVAVRFRIAEVILYVCVLSLDTRRLELSDYLVQPQLEAPASNSRDVCPPLTLNRYLSNLLAQSPSSPMRTDEKVMSPSSSNRHEDDDEDDGLAASSSSRALEAVLRDGTERVIVVNNLLVLIGMLGALIVAVLHGASPLGGVPECRATLRADWTRVLHGMGGRHNVLLFPTPLGVLMERTELVDLLQFLTDWEVDLNRMRAYLELECLALCEASNHIASASLDGHVRLWDLDTNRLLAALKLRSARDDPSGSFGTLRASGGASARPSIDPASVARAMSGGGLAAALPTGRGAAPSSSEGNTDESSLVPWCIDIAEDIVAIGCSDGSVMVWETESGALQCLTQDEGTTHDVVASISCIKLCSNLLLVASNSGVLELWRKGPRQSTHMTQLATSSPTQSDGDLRATATTASSAGPTPTVHRSRHVRSRSWDLRSMSGVHNLGPVTTSTGFGIANGDDSGDSTLLSEGLEGAPPAFGHEADARGSPLLGSSPSREVTELTHGSGLSGKGNLRAFLDEAAASRGSCGVIFRSYRDSSSSLSGDRPIYSGDGSPSYNFVRVFSANAHQAAIVSVTTLGDYIITASADGTCKVWRMLDFGLHGSLLGHEAAITCMTTFTGTTVHSTHHNNHALAANTIVTGSRDRTVRVWDMDRMECVSKLEGHGATILAVACSAKHVVSTASDSTLRMWLRKSGRCMRTVQTAAPLVALHLHPSGVLLTAVEGRLTAWDVLAGGERLRTIELETDGTEQGSRLTLGGKESSRVIMLEDKVIVDLDRNLKTCCVAFGSANFVQHQHQSKPKSLSVSLCLLSVSLCLSLCLSLSLSLSRSLSLSLSLSLSVSVSVSLSLPLSLSLSLSLSLSLSLSLSRSLALSLF
The following text describes a protein:
Function:
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
LLFTGNMTAALQAALKNPPINTKSQSVKDRAESIVLKVLISFKASDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAVLLQWHEKALAAGGVGSIVRVLTARKTV
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds to GA-rich elements (GAGA-repeats) present in regulatory sequences of genes involved in developmental processes.
Subcellular Localization:
Nucleus.
Sequence:
MAERDAAIRERNMALEERKRAFAERDMAMLQRDAALAERNALIQERNDAIAALRLQDSSTNDNNMVPDSPGNGTESGAKHIYNQQQMYRTTAEAAHGSMEDPSAGYLKDTDTSEAKIPKKVKRPKESRHNKQAKIPRVGKIGTDNLSMQVIATTSDDWANLQEMDSDKEGDTQLTSWKDNLGFQINFDESAMPVPVCSCTGTPQPCYKWGHGGWQSACCTTTISMYPLPQISNKRYSRVGGRKMSGGAFSKLLNRLAAQGYDLSIPLDLKDHWAKHGTNRYSTLK
The following text describes a protein:
Function:
Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.
Subcellular Localization:
Bud. Bud neck.
Sequence:
MDEETDLALLDQHLLKTNQLGQRMTNILGQLDNRLYRLDKAIVPLGIQPLTRKDANIDALLSYLSGKPVASTPNSRPAANRQASTSSTTKGYSVEPASAIPPHVTASTSSKPPSRSTTPTDDVVLLTRGPDIMALGEYFSALDGVIDDLERMYKGLMEGRGGAREAGVKDLTQLVETGFRSMTQLFLKLSKDGMGRTFDVDTLLNNGPPTPPNLFPSLNTLLPLTTKMTVYLNPANPTPKTLSIIQPIFEDAVSQFARLRGDWMCRSLNALAIKVEEADEGGIWENQGGRGKVGNIMSIWEAIMHAAEGETMLAESLFPNHPPQTILTQTLASPITLANKALSPTLSTLKKYLSRHTFTALDLYASVSRLLPQWDHIMSSCLSRLGTPQSPATTELVTALDQSVNTLRSLSLRSFPEMLVDVRSATTEGPPTSVISDITYSTITYLESLMEYEQVVEGLLGKSKSERSWLMGLNELPSNVRSADEEGGIVKFFVADVLGTLLNHLHAKAKGMKRPIGQAFLLNNVSHIRNMLIIQSNSDITGPGAEAMLNKAVRDARTQFISEFQSLTSLLTSAPHSHTQRFAVPQLPTSERHNLKESSIAFFERLGELEGVMARYPLNRQDPEMRDSVGREVEGVVRKGYEAFAARCQSKGAEKYVRSSPDEVSRRVQSMFR
The following text describes a protein:
Function:
GTPase that plays an essential role in the late steps of ribosome biogenesis.
Sequence:
MHKVAIVGRPNVGKSSLFNRLIGRREAVVADFPGVTRDAKEGLMLYHNHRITLIDTGGLWSGDEWEQAIREKAEWAMEGAQAVIFVLDPREGLSAADYEVADWLRRLGKPVIVTANKIDSQKHEPYLAELWGLGFGDPVAISAEHARGLDDLMDRVMKYLPEDDEDVPDIAPIRISLIGRPNVGKSSLLNAITQSDRAIVADLPGTTRDSLDVEWDYGGQRFVLVDTAGIRKKPDTAIEDFAIQRSQAAIERSDVIWLVVNATDIGDHELKLANLAYDSGKPVIVVVNKWDLVPDAELKSTEKDLNQKLHHISFAPRVYTSAINDYGIHDMLAEAMKLYEKWQSRIGTSELNRWLEVWQMKQRVPNFHGKPLRMYFMTQVETAPPTFAIFCNRADFVTRAYEGFLQNRIREDLELAGVPVRLKWKEKGPYKKGEADED
The following text describes a protein:
Function:
May have a pivotal role in cell differentiation of different cell types. May have a specific role in early thymocyte development. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses (By similarity). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MGRAMVARLGLGLLLLALLLPTQIYCNQTSVAPFPGNQNISASPNPSNATTRGGGSSLQSTAGLLALSLSLLHLYC
The following text describes a protein:
Function:
Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MADDKKGQMGNVDDIQAKLDKRLGPEYISKRVGHGTTRVAYIEGWKAINLANQIFGFNGWSSEVKSVTVDFMDERQGRFTIGCTAVVRVTLSDGTFREDIGYGTVENDRRKSGAFERAKKSAVTDALKRSLRGFGNALGNCLYDKDFLSKIDKVKFEPPDFDEGNLFRATDENNELSRANTVTDHSEGPAPKKRNAPLPPAPRPGAMRPEAAHAAPAPSEPPLERPRSSENDQEDLLDDSFMFSDELQDDDLINIGSAKKAPSGVPRPAPPPPPRAWPPQDAPVAFVTAKAAPDLQAHGPVPPTHLFDPKFQAQSIRHTVDQTTSAHVKLSVLREKGIDQARDDIYSKFAPKGKILPPPDTATDPDPTLAARPALSAPQNLPTNTSSIQRPTMIELPKLHFPQPTAVPLPNVPASRREVGRPKQSPPSLRKPPPQ
The following text describes a protein:
Function:
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
Sequence:
MGRLTNHQSATVSEDQILAALRQVQEPELGGDLVSRQMVKHIAICDGIVRCTIELTTPACPLKDQIRSEAEAAVLAVPGVREVHIEFTANVRRPAGIPEQSAIPGVANVIAVAAGKGGVGKSTVAANLAVALAQMGAQVGLLDADVFGPSLPLMLGVRGQPMAVSDANGQPMMLPLSNHGIKVMSVGFLIDESQPVIWRGPMVSQLLRQFLYQVAWAPLDYLIIDMPPGTGDVALTLAQSLPLTGALIVTTPQQVATIDVIKAMEMFRKVNVPLLGIVENMAYFIAPDTGKRYDIFGSGGAERLAQQLGVPVLGQIPLGMSVREGGDNGQPAVISDAPDAYADIFRELARQVAARISVLQYAMV
The following text describes a protein:
Function:
Has a stimulatory role for the envelope antigen F1 secretion. It seems to interact with the subunit polypeptide and to prevent it from digestion by a protease.
Subcellular Localization:
Periplasm.
Sequence:
MILNRLSTLGIITFGMLSFAANSAQPDIKFASKEYGVTIGESRIIYPLDAAGVMVSVKNTQDYPVLIQSRIYDENKEKESEDPFVVTPPLFRLDAKQQNSLRIAQAGGVFPRDKESLKWLCVKGIPPKDEDIWVDDATNKQKFNPDKDVGVFVQFAINNCIKLLVRPNELKGTPIQFAENLSWKVDGGKLIAENPSPFYMNIGELTFGGKSIPSHYIPPKSTWAFDLPKGLAGARNVSWRIINDQGGLDRLYSKNVTL
The following text describes a protein:
Function:
Binds to phospholipid vesicles in a calcium-dependent manner in vitro. Prefers phosphatidyl-serine containing membranes. May have a role in the membrane cytoskeleton scaffolding or exocytotic processes. May be involved in oxidative stress response (Probable).
Subcellular Localization:
Membrane.
Domain:
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence:
ATLTVPTTVPSVSEDCEQLRKAFSGWGTNEGLIIDILGHRNAEQRNLIRKTYAETYGEDLLKALDKELSNDFERLVLLWALDPAERDALLANEATKRWTSSNQVLMEIACTRSANQLLHARQAYHARYKKSLEEDVAHHTTGDFHKLLLPLVSSYRYEGEEVNMTLAKTEAKLLHEKISNKAYSDDDVIRVLATRSKAQINATLNHYKNEYGNDINKDLKADPKDEFLALLRSTVKCLVYPEKYFEKVLRLAINRRGTDEGALTRVVCTRAEVDLKVIADEYQRRNSVPLTRAIVKDTHGDYEKLLLVLAGHVEN
The following text describes a protein:
Function:
May play an important role in trophoblast development and in the regulation of bone formation.
Subcellular Localization:
Secreted.
Sequence:
MASLFRSYLPAIWLLLSQLLRESLAAELRGCGPRFGKHLLSYCPMPEKTFTTTPGGWLLESGRPKEMVSTSNNKDGQALGTTSEFIPNLSPELKKPLSEGQPSLKKIILSRKKRSGRHRFDPFCCEVICDDGTSVKLCT
The following text describes a protein:
Function:
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types. Proto-oncogene, which promotes T-cell lymphomagenesis when its expression is deregulated.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGSNGLGKAATLDELLSTCIEMFDDNGDLNDSYLPRIVLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGHEKHISLMDISSVPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLXDTHSHLSSEVTKKLDEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPGSLPGSPALPPVQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKISVRLQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPTVQAGVDVVDRGTAFEPDQDDGQDEAKQGGEDG
The following text describes a protein:
Function:
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg1.
Subcellular Localization:
Nucleus.
Sequence:
MNKFFYSIDNNNNNISFKNHTLIWPSLTLGNIGQLTIDVLICSFEFKRIGFIVDENITPIIGNDCFTTLDNNNGIMSTSIEVYQSSLFPSITLVQQRSPIVDGRIPNFSENLFKWINAEEIKEILFLSSSNANKRVDSQLTGSQVRFIKSDNVDKNIISKLNEMNISEMELTVQSPEGETIQLSNRLTGLAKEIYSTINSKNNDNNNKVSFLCLNLFCSEGYNTNEALQMSNLIYNFIKNQESPSSPQLKTPSCWKLLQGPTFDQSLFF
The following text describes a protein:
Function:
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.
Sequence:
MATLYSTTCRSISYSLTPSSSSSSSLSINGQNHHQRLNFSSCIAKRVLPVKVSFHSRRNFHLNVVLMQDGAVATPVTPVENETPFKKLKDGFLSSVPSTEEIKEAASFDVNKDESTVSITVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRNMVSKTLTCRIDKRENCDEKMDQFLKRCFYHSGQYGSQENFAELDKKLKEHEGARVSNRLFYLSIPPNIFIEAVKCASSSASSGIGWTRVIVEKPFGRDSDSSAALTKALKQYLDEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQLIFSEDFGTEGRGGYFDNYGIIRDIMQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMRPLQLEDVVVGQYKNHTKGGVTYPAYTDDNTVPKGSLTPTFAAAALFIDNARWDGVPFLMKAGKALHNKSAEIRVQFRHVPGNLYNRNFGTDLDRATNELVIRVQPDEAIYLKINNKVPGLGMRLDRSNLHLHYAARYSKEIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPVLKELEEKKIIPEYYPYGSRGPVGAHYLAARYKVRWGDLGIEQ
The following text describes a protein:
Function:
Fatty acid hydroxylase; part of the gene cluster that mediates the biosynthesis of the glycolipid biosurfactant ustilagic acid (UA). UA is a secreted cellobiose glycolipid that is toxic for many microorganisms and confers biocontrol activity to U.maydis. UA consists of 15,16-dihydroxypalmitic or 2,15,16-trihydroxypalmitic acid, which is O-glycosidically linked to cellobiose at its terminal hydroxyl group. In addition, the cellobiose moiety is acetylated and acylated with a short-chain hydroxy fatty acid. UA biosynthesis starts with omega-hydroxylation of palmitic acid catalyzed by the cytochrome P450 monooxygenase cyp1. Terminal hydroxylation of palmitic acid precedes subterminal hydroxylation catalyzed by the cytochrome P450 monooxygenase cyp2. Sequential glucosylation of the hydroxy fatty acid is probably catalyzed by the glycosyltransferase ugt1 (Probable). The cellobiose lipid is further decorated by acetylation of the proximal glucose residue and by acylation with a short-chain beta-hydroxy fatty acid at the distal glucose residue (Probable). The acyltransferase uat1 may be a good candidate for catalyzing either acetylation or acylation of the cellobiose lipid (Probable). The fatty acid synthase fas2 may be involved in synthesis of the carbon backbone of the short-chain beta-hydroxy fatty acid esterified to the cellobiose disaccharide (Probable). The secreted UA consists of a mixture of both alpha-hydroxylated and non-hydroxylated glycolipids; therefore, alpha-hydroxylation of the long-chain fatty, catalyzed by the fatty acid hydroxylase ahd1, occurs late in UA biosynthesis and may be the last step before secretion.
Sequence:
MAGTSRNVRVLVTGANGFVGSHIVSLLLSRGYVVNATVRRQTASEKLIATFACDRLHVFVIPDLTSEQALDEAIRGCKYVVHVASTVPSKEQASGIDIDSAISSIESVMNSAVAHASEKVVLTSSMSTHLDVKAPILNESTWYTPDRSSTKLMVQYMSSKTLVERRAWELSSTLKLPLTTVAPVYIGGPTIIHEQDPKSSVSNQDLLRCIEDESRSRIPGWIDVRTVAHLHLHAIEDHSLNGRRILACTHNRGVVPMDCSLMNSLLAKDSAALIDFDRTKRDLLEQIDAFNSGQTRRVVA
The following text describes a protein:
Function:
Proton-selective ion channel open at neutral pH. Actives at neutral and alkaline extracellular pH, likely participates in some alkali-related physiological activities.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSEELAQGPKESPPAPRAGPREVWKKGGRLLSVLLAVNVLLLACTLISGGAFNKVAVYDTDVFALLTAMMLLATLWILFYLLRTVRCPCAVPYRDAHAGPIWLRGGLVLFGICTLIMDVFKTGYYSSFFECQSAIKILHPLIQAVFVIIQTYFLWVSAKDCVHVHLDLTWCGLMFTLTTNLAIWMAAVVDESVHQSHSYSSSHSNASHARLISDQHADNPVGGDSCLCSTAVCQIFQQGYFYLYPFNIEYSLFASTMLYVMWKNVGRFLASTPGHSHTPTPVSLFRETFFAGPVLGLLLFVVGLAVFIIYEVQVSGDGSRTRQALVIYYSFNIVCLGLTTLVSLSGSIIYRFDRRAMDHHKNPTRTLDVALLMGAALGQYAISYYSIVAVVAGTPQDLLAGLNLTHALLMIAQHTFQNMFIIESLHRGPPGAEPHSTHPKEPCQDLTFTNLDALHTLSACPPNPGLVSPSPSDQREAVAIVSTPRSQWRRQCLKDISLFLLLCNVILWIMPAFGARPHFSNTVEVDFYGYSLWAVIVNICLPFGIFYRMHAVSSLLEVYVLS
The following text describes a protein:
Function:
Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7. Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (By similarity). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX21. Acts as an activator of the seryl-tRNA synthetase SES1 by increasing its binding to tRNA.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome. Note=Cycles between the cytosol and the peroxisome.
Sequence:
MPSVCHTSPIEKIIQQGHRIQNDSLIPSKRTKLAHTELTAHYATEDSHVEKHFLHNGSNFDGIDNVRYQNQPSPLTFITPNNTVDSSDWVPQFSSMKIDDSLEFSSEYKRLYSNYESQQRLNSSRQHLPFKNCMIRKTSCTYPPQKTLRQQRQGNRDNPTDAFQFDAEFQVLEREIQKERYEPITRRDEKWFDQDQSELQRIATDIVKCCTPPPSSASSSSTLSSSVESKLSESKFIQLMRNISSGDVTLKKNADGNSASELFSSNNGELVGNRHIFVKDEIHKDILD
The following text describes a protein:
Function:
Not known. Putative receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNQEFLIQLGERACKNAENLTLPAELEGIFFCAPSSRESLATQVFVAIAFVLLMATAIIGNSVVMWIIYQHKVMHYGFNYFLFNMAFADLLIALFNVGTSWTYNLYYDWWYGDLCTLTSFFGIAPTTVSVCSMMALSWDRCQAVVNPLQKRPLSRKRSVIAILIIWVVSTVTALPFAIAASVNSLYTYDVVTSTVSKAHVCSAPVNTFFEKVLFGIQYALPIIILGSTFTRIAVAFRATNEATDSSLKNNHTRAKSKAVKMLFLMVVAFVVCWLPYHIYHAFALEEFFDAARGKYAYLLIYWIAMSSCAYNPIIYCFANERFRIGFRYVFRWIPVIDCKKEQYEYSQLFPDKMRSMAISLQKGRVNSSCLDKKVKENSSQDLVCVMHSEKNTKKYSKVHLLSCHER
The following text describes a protein:
Function:
Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (By similarity). Participates in development of brown adipose tissue and browning of white adipose tissue (By similarity). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Domain:
The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix; The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence:
MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGHPHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGTSAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC