lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MKTVLFFLYILGTAAAIPTNARFLSDHSKPTADSLSSIQQAEILVTPNNTAIPVLGVEDAENEKEIAVSIDHPNHEAEKSSVLKSKEENHDESADQGQSYSQELGLQDEEESESDLSENLEYMPSERTLDLKEDMGEPQNKKLSENIDLLAPNISSIVDPNHQESITKTEKEQEQPINDLHPQLNKSNKHSQDVSDQGNEEQDSNIPNGEGEGEEDPGEVGTHSNNQERERMFPKEHSNIKEEEDHTQSDDVLEESNQPTQVSKMQKDESEQGNQEQEEDSSNAEMEDETASKINKHNQDPEWQSQEEKPEVISDHEEIDKKTVSEALLVKPTEDGNIMPRNHGANDDGDDEPRHDASDDYEFIPSEAFIEAERSQSISYHLKYEEERERERARENGNVDASEPGEYQGAKKAESSPNEDESSYENNRMVHDIDSCMNFQCKRGHICKADQQGKPHCVCQDSVTCPPTKLLDQVCGTDNQTYASSCHLFATKCKLEGTKKGHQLQLDYFGACKSIPICTDFEVTQFPLRMRDWLKNILMQLYEQNPEHAGYLNEKQRNKVKKIYLDEKRLLAGDHSIDLLLRDFKKNYHMYVYPVHWQFGELDQHPMDRVLTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITLEEWGHCFGIKEGRSCCVLRLKPQDSKGAASQKT
The following text describes a protein:
Function:
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Melanosome.
Sequence:
MVKAGTKTSSDSSFCGIRNRRVRIAFVLRVLFVLCLGSLHVLNLALAPTDSKRTSDGLRSVGAAGGRRLLTIPQSEVELLDLLNGTLPSEFSSTTEETTVDGVDNATEPAATERNCTPAAIFEFPSDGFTREDRRHGWILVHIVIACYCFWLLAIVCDDYFVPAIELMCKKLQVKEDVAGATFMAAASSSPELFINCVGTFVTKGDLGVGAVVGSAVFNILAVPAVCGLLGGQVVQLRWWPVTRDSMMYGIAVMGLIGVLYDGKVMWYEATVLVSAYVFYITAMYCNDTINRFMSKTFRRKSYIRPYTEVTEISPLLSNGAGAKSAPGAAKNGTNGQHACDSDASDDSFEEYELATSPWNHRDDSLTAFVCRWPITLVLWATIPDCRRYPRLRLVTFFACIFWIGITSYFVAFLITVVGDTIDIPDSVMGLTFLAAGTSVPEAVSSIIVTNQGHGEMGISNSIGSNTFDILLCLGLPWLIKSLAFPAVPGERWVALNSSGLTYSAISLLSTLCGLYLAFWCKRFKLDWKVGLTCLSMYIGFLTVSSLIELNVFFPVNLPTCPH
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
Sequence:
MGKIQELSPELINQIAAGEVIESAHSVVKELMENSMDASATQVDVESKDGGLSLLRITDNGTGIEPEDLEPALKRHATSKIQDYKDLESVLSYGFRGEALASIASVSRLTLESGTKEQKTAWKTRSVAGKISEKEEIPGFIGTKILVEELFFNTPVRRKFLKSIRSEDKKIRDRVTTQALAREDVRFRLFQDGKEVFVLPTRENKKERIIDLFGENFRDHLLEVSLERGGIQATGYISDPDFYKSNRTGQFIFINGRPIEIKYSSVLLKKAYDELLPPNGHPYCFLFFEIDPSRVDVNVHPAKREIRFLDEDGFNGFFLALIQKELRSSTPVSFLELKKRLLKPAPETHSTTSFYQARSSGKNPLLGRELFSGVSKQEGFELDRMGPGVSLSELTDERVKHSSFVPKKHFGVLFETFILAEAEDGFYIIDQHTAHERIRYEEVLRKLEKRNYGIQPLLTPIRIDVSKQEQEDILNRKKEYEEVGIFLDPLGEDSIVLREIPAYMEPGQEKEIVLDFLNRTEGKETSEPELYDLMAKCVACRSAIKKGDQLSDPILAEILNRLSYCENPSRCPHGRPTLVKLSRDDLERMFHRK
The following text describes a protein:
Function:
Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein MoaD.
Sequence:
MLATSGGSGVEALSDEEVQRYVRHITLPGVGREGQQRLKQARVLIIGTGGLGSPACLYLAAAGVGTIGLVDFDVVESSNLQRQVVHGYSTLGMPKVESAQRRMQDLNPYIEVVTHRYAIDADNAQSLIQSYDLVLDGTDNFATRYLVNAVCAKLGKPLVFGAIYRFEGQVSVFNLEGGPCYQCLFPNNPPPEMAPSCNAGGVIGVLPGVIGLLQATEAVKALVGLGKSLSGRLLRFDALLMHFNEVKFNRRDDCPACGKTAAENPRHWREGLLCQASAAPSQRLDDDRYIDPGCLLQLMKSNSENYALLDVRDAGELEVCQLPGIVHVPLNELASHFANLDFSKRYILVCYAGTRAERAAIQLMGAGFSNVQVLDGGMKRWAKEIEQHMPMY
The following text describes a protein:
Function:
Catalyzes the interconversion of ribulose-5-P and ribose-5-P.
Miscellaneous:
MISCELLANEOUS: In mycobacterial enzymes, the usual proton acceptor is not a cysteine, but is remplaced by a glutamate.
Sequence:
MRVYLGSDHAGFELKQQIIAHLEQSGHQPIDCGAFSYDADDDYPAFCIAAATRTVADPDSLGIVLGGSGNGEQIAANKVPGARCALAWSVETAQLAREHNNAQLIGIGGRMHTVAEALAIVDAFVTTPWSKAPRHQRRIDILAEYERTHQAPPVPGAVG
The following text describes a protein:
Function:
Component of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Binding by the elongator complex stabilizes microtubules and promotes their growth. This induces central spindle asymmetry, promoting polarized signaling endosome trafficking during asymmetric cell division and cell fate assignation of sensory organ precursor cells. Required in germ line cells for microtubule organization involved in oocyte polarization and chromosome organization. Involved in InR-TOR (insulin-like receptor-target of rapamycin) signaling regulation of cellular metabolism, autophagy and apoptosis.
Miscellaneous:
MISCELLANEOUS: Named 'poly' for the abnormal shape of larval neuroblast nuclei that resemble the nuclei of mammalian polymorphonuclear leukocytes.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Concentrates in the nucleus upon insulin stimulation. During asymmetric cell division of sensory organ precursor cells the elongator complex preferentially binds and stabilizes microtubules on the anterior side (pIIb daughter cell) of the spindle.
Sequence:
MATSVLLACGLNEQKLPGFVHISEESNVDASFLISCVLGQRLRISNAGTLLVCLQHHYQHYFNAGMRLGYNTNIFQGKTLGVIDVLSDMAGEGLASKWLTNTEGQTLTDQLVEDIRAQVERNYASRNSYTVLIDNLSILFNLGASKLQVQQFCQDLAALGKEREKLTVITKLSNSDIYQLTDNNVAKLGQVRIQVLRLKSGVFREVDGKLLIERVLDEGNYACEETRKEVLYKVNDRNVKVFAPGEIGVKV
The following text describes a protein:
Function:
Endoplasmic reticulum membrane-bound UDP-glucose:dolichyl-phosphate glucosyltransferase involved in protein N-linked glycosylation.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MIDLFINIASFTIYGIPVIPLFIIVFVILSYYLLLLHDESPLWLEKENVYIDVKEGEQHQFPSLVENKNPIDNIYLSVIVPAYNEQIRLPSMLDDAIKFLNEKSKKDLKFSYEIIIIDDGSKDSTAKLVTSYIEKQPSSNIRLLKLKQNRGKGGAVKRGILCSRGKYCLMVDADGATEFKDFNRVEDIMHKIEKNDLGIVCGSRSHLVDSDLVAKRSFLRNILMYGFHIFVQTLCVKGIKDTQCGFKLFTRETARRIFPTLHIERWAFDVEILYLAQKLNIPIAEVAVNWTEIDGSKLDPFSSSIQMAKDIVRIRFRYLLGIWKIKS
The following text describes a protein:
Function:
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MLQEQQAEWEPLNRLLQQRGFRPVLFADPVENKNPAELGLLDRKSAAALRRTLETLLADSDRRQALLQELVGSNNRLREEVQEQMSRAAQHSQRASELQALLDQVKVKVQDLEDRCICRAAQTHSRTLQLQRHSAEAIRRCEQLQQKLRRKEEEAAKLRWKLRFAVEQEERRLARRNRSFQEICGKTSRLQTAADQRVLDVIDFYEAERRRLMEELRSARGGAEASELQDGGERTAAGAPSSFKTDLKVFPQKERRTQLEAELDSRPTREQPKGRRRRHLEGLQPGAARLTTVGGAKTKGVEEPPREVWLCAQFRTLLSDIRAVIGSPASSKEAESELADFQALLPVLEDWAGQRRLLKDLRDLLVDLSGGPREDSAAAVKVEDLIVLVEDMLENASKDPEQKLRNSAPYTLSAIVSHFQKLFDVPSLRGVYPRMNEVYTRLAEMTNAMRNLKDALDLDGRASPAEVVNHVSALASAQQSGLRDLLEEADIDSVILKVKQHDEFLPAFHRLITDILQTLGVTHLEEILPALKSLQRSAA
The following text describes a protein:
Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Prefers EA2 as substrate. Has weak activity toward Muc5AC-3, -13 and -3/13 substrates. Plays a critical role in the regulation of integrin-mediated cell adhesion during wing development by influencing, via glycosylation, the secretion and localization of the integrin ligand Tig to the basal cell layer interface. Might have a role in protein O-glycosylation in the Golgi and thereby in establishing and/or maintaining a proper secretory apparatus structure. Together with Pgant35A, regulates integrin levels and activity-dependent integrin signaling at the synapse in neurons and muscles.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Domain:
There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding; The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
Sequence:
MGLRFQQLKKLWLLYLFLLFFAFFMFAISINLYVASIQGGDAEMRHPKPPPKRRSLWPHKNIVAHYIGKGDIFGNMTADDYNINLFQPINGEGADGRPVVVPPRDRFRMQRFFRLNSFNLLASDRIPLNRTLKDYRTPECRDKKYASGLPSTSVIIVFHNEAWSVLLRTITSVINRSPRHLLKEIILVDDASDRSYLKRQLESYVKVLAVPTRIFRMKKRSGLVPARLLGAENARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVVICPVIDIISDDNFSYTKTFENHWGAFNWQLSFRWFSSDRKRQTAGNSSKDSTDPIATPGMAGGLFAIDRKYFYEMGSYDSNMRVWGGENVEMSFRIWQCGGRVEISPCSHVGHVFRSSTPYTFPGGMSEVLTDNLARAATVWMDDWQYFIMLYTSGLTLGAKDKVNVTERVALRERLQCKPFSWYLENIWPEHFFPAPDRFFGKIIWLDGETECAQAYSKHMKNLPGRALSREWKRAFEEIDSKAEELMALIDLERDKCLRPLKEDVPRSSLSAVTVGDCTSHAQSMDMFVITPKGQIMTNDNVCLTYRQQKLGVIKMLKNRNATTSNVMLAQCASDSSQLWTYDMDTQQISHRDTKLCLTLKAATNSRLQKVEKVVLSMECDFKDITQKWGFIPLPWRM
The following text describes a protein:
Function:
Transcription factor. Binds to a sequence motif, 5'-TTATTGGCTTCGTTAA-3', which may be involved in AIY interneuron function, in the regulatory elements of target genes; binding is more efficient, in vitro, together with homeobox protein ceh-10. Required for specification of the AIA and AIY interneurons and the NSM neurons. Positively regulates the expression of a number of genes including ceh-10, ceh-23, kal-1, hen-1, ser-2, unc-17 and sra-11 in AIY neurons, and cat-4, flp-4, bas-1, ptps-1 and mgl-1 in NSM neurons. In concert with WNT/beta-catenin signaling, initiates expression of homeobox ceh-10 in AIY, but not in the sister cells, SMDD motor neurons. Also acts in an autoregulatory feedback loop to maintain its own expression. Plays a role in the thermotactic response, olfactory imprinting, regulation of longevity, control of dauer formation and axon outgrowth and pathfinding. Not required for normal chemosensory behavior.
Subcellular Localization:
Nucleus. Perikaryon. Cell projection, axon.
Sequence:
MYFQSLSADPLDSVNTTTDFNQLAQLLLMLTNSSSKETIATHVVTNSVPSAFQFDWSSHFKEEYDLVEKLNSPQYTNLTSISPSSSTDSNNLILRQIQIPKIEPALLNQCCLCTFAIVDKEISVVDGKYYHNNCLRCQMCDIPFEYSDKCYVRDGVFLCRADHAKRYQKCCRKCEIPLNREDMVMKAKEMIFHHACFVCFICGIKLNPGDYYTMSPQGHLYCHAHYNAVRSTVLCEEAAVATVPAVVAPPPPPPTTTTAPPPAAPEQPPREASTEAEASTDEDGNGSGSQRSKRMRTSFKHHQLRAMKTYFALNHNPDAKDLKQLAAKTNLTKRVLQVWFQNARAKYRRELHDGGRSSSPLCVSAPLASMDMNPPLSSSSSGHSTDGYQLNTPPLSSEIYSPNSNYTHL
The following text describes a protein:
Function:
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
Subcellular Localization:
Cytoplasm.
Sequence:
MVTICVIPARYGSTRFPGKPLAFLKNKPIIQHVYERAKSSKMIDEVFVATDDSRILHTVESFGGKAIMTSSKHPSGTDRIAEAVDKLLQEGYNLQESSIVINLQGDEPLIKKEMIDQLIDLMKNENDSIGTLAKRIEKEDDFFNPNIVKVVFDKNGYALYFSRSPIPFDREKFIKGFSKNNFMYKHIGIYGYNVRILKNFVGLPMSRLEEIESLEQLRALENGIKIKVGLTEYDSFGIDTPEDLEVAEKCLNTYS
The following text describes a protein:
Function:
Involved in recombination-dependent repair of stalled or collapsed replication forks.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MDYDLFQSDDEEILATFIQATQKQETLSAQIDVDDSEEDLVDGLHLPEFNCSGRDTLKSQLCEGGFLGNGYAQLDPPRSRLDYLCFDFAPAQLAVGAVRNYLYGEACKNVQKLLTVVMGQQHLQATAASMNSGWYRVRQQVTHFYHLMLLLRGNELLPSHFLDGFRQLLNDQLDADTWKVLYFAEHNKGNDCQAPAYHLYHGVLEWRFLDLHILYASGNDQAFLGQLERTLDDLIVCAGHHYRSKHRSELIHSSPFMCRCNKELWLLLKRLIPKWLGERELDFWTLFHKAMQRHKSLHFQGESNAISLAYHELYSWLRLGLARLDEYNSEGWYQPDHSPLTAAPESFQTASLLKQFLASQPDEQQRRVYLIQLSPLQLQLGKPDTDVLCQLWEYFHRSLNCNFSVGTELDQLPLTCSNGSAYVDRYNKLLSKSHIEDLNLSSFTMYAWMLGKTLKLLPSQGRSNQRQKLLGRIFSKFSAAKLLALNEPGIHHVIELFLCLLLCHEDLSELAPKLREMLLCLALEKLPPVRRILVAKGHMALLLLHAQHRLSMDDYVSKLLNQLATIRNDAEVGAIYVGSLQAIFNLADDFNRGEQQLLGPWLAHYVEKCGQASQDRVWQTLHNLILRLSERRAVAGNASGIKEALQQHIMPLVRTQYVSSHSSWLPKLAANFIALENNGDKLLLGFLQGPEPINMAASAQLLLQVLEDGGRPASSTILQVWVKSLVLLNAQHESVLALMPHVTQLEEFRLLAIDPTSLEGGREPLCAFFGALGRRAQQEEAAAHVRMQLSHKLHAYVNHFELWLPPDRSRSELGSRFYSFLAIVIYNCSTLAYVRSKPSCFFHLAMVRFLLTTQLQAGVPPEGRLPQVVHKIFPVLLQGIGRLPYRTDAYVAKTLEQLVQHWTPHFSFSSNAKLVARPYATLLQADVDGELAQFVLQLLVTQFLVVQRRRAGQHAGLVITIMQQLIESTGKEQEEQLLTVLRGVHIPLLEHVMFVDEVDLSRNQVFGLYKVLISHDAYKRSQAVRDMCSNHLRSLAEKHLAHCTYFYFQMLINLAELAPDLVAPILSFIREQAEQVELKRGAGEDVGIRKCLQRLQKVLSRV
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the effect of toxin ParE (By similarity).
Sequence:
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV
The following text describes a protein:
Function:
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
Sequence:
MWVFGYGSLIWKVDFPYEEKIVGYIKNFQRRFYQHSTDHRGIPGKPGRVVTLVPGDATDRVYGVAYKISDQEKDSVVKHLDYREKGGYVRTPVLFYPKDKDKQPFEIIIYVANDDNPQYAGPADADSIANQVVKSVGPSGTNIEYVFNLAKAMRDIAPEVHDEHLFTIERKVQNLLKFNTPESFSRSLN
The following text describes a protein:
Function:
G-protein coupled receptor for tyramine, a known neurotransmitter and neuromodulator and direct precursor of octopamine. Expression in amphidial sensory neurons suggests a role in chemosensation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMSSYVMSPVDETYTLFQILKGSALFLLVLWTIFANSLVFIVLYKNPRLQTVPNLLVGNLAFSDLALGLIVLPLSSVYAIAGEWVFPDALCEVFVSADILCSTASIWNLSIVGLDRYWAITSPVAYMSKRNKRTAGIMILSVWISSALISLAPLLGWKQTAQTPNLIYEKNNTVRQCTFLDLPSYTVYSATGSFFIPTLLMFFVYFKIYQAFAKHRARQIYRQKLAVSSHVIRKHIESTILHEISHVLPTSDEFAKEEEEEEDSESSGQVENGLGNGNDAIIEEDECEDEDSDEKRDDHTSMTTVTATVTGPTEAPYMKREAKISKSVPIEKESAIQKREAKPMRSVMAISYEKVKRHKNRKERIYRKSLQRKPKAISAAKERRGVKVLGIILGCFTVCWAPFFTMYVLVQFCKDCSPNAHIEMFITWLGYSNSAMNPIIYTVFNRDYQIALKRLFTSEKKPSSTSRV
The following text describes a protein:
Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHKACFSDDSDEPVGDFPCGEEPPARLCENGTFCRVYWKGPNFGITNFDNILFAVLTVFQCITMEGWTDILYNTNDAVGYMWNWLYFIPLIIVGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDVLKRATIKKSKNDLIHAEEGDDHFNDICSVGSPFARSSLKSGKNESSSYLRRKEKMFRFFIRRMVKAQSFYWFVLCVVALNTLCVAIVHYNQPQWLTEALYYAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNCFDFGVIVGSIFEVIWAAVKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIVSLLFLLFLFIVVFALLGMQLFGGQFYFEEETRNTNFDTFPTAILTVFQILTGEDWNLVMYFGIESQGGVSKGMFSCIYFIILTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEATNQKLALQKAKEVAEVSPMSAANLSITAFVKQTQGAISRSSSVSNVNSPDPSVCSAVIKTQLPAYPSAWELAPSCARHLHAMDPCKQQNSTKCRSVWEQRTSQIRKHNFRASCEALYSELEPEDRLRYATTLHLRPDMKSHMDRPLLVEPQDSTETKDGSPDAPAPNEIEPVPGVTTEPSARKQHRHRDRGEPNGGGRENGNHNGDSGSNDREERQRQHRSRSKEEDGSKETGRGERNRSQERGKRHHRRASPEDGTEREHRRHRTHRHSADRQGKEGNGQPPSGGKGERKSRHRGGGSRSGNREGEGTNRGTGENGEEPPRSRHRNRHKALSTYDTEDKKENKDGESAEKEHRNHRPRENRNESELPPGGLQQLAEQPEDADNQKNVNRMALPHPERSSTINIPVTITAPPGESAVIPINNVDFDGKSEEKKEMEDDLTKNGPKQILPYSSMFIFSTTNPVRRLCHYIVNLRYFEMVILVVIALSSIALAAEDPVQADAPRNDVLKYMDYIFTGVFTFEMVIKMIDLGLLLHSGSYFRDLWNILDFIVVSGALVAFAFSSFVGGNKGKDLNTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVVAVQLFKGKFFYCTDESKDLEKDCRGEYLNYENNDVRAQAREWKKYEFHYDNVLWALLTLFTVSTGEGWPNVLKHSVDATYEDQGPTPGFRMEISIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKMWRFVVSPPFEYFIMVMIALNTIVLMMKFYGAPQTYEDMLKCLNIIFTSMFSLECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIADTENFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALSDDSSINRHNNFRTFFQALMLLFRSATGEGWHEIMLSCLSNRPCDPRSGNTKEECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACCRIHYKDMYNLLRVIAPPLGLGKRCPSRVAYKRLVRMNMPISDTDLTVHFTSTLMALIRTALDIKLASGGIKQHECDAELRKEVSSVWPNLSQKTLDLLVPPHKPDELTVGKVYAALMIFDFYKQNKNNRDQSHPQSGVLSQTGTVSLFQPLKATLEPFGNSKMFIRQKSSASLNNGGLVPDQDMGIRESSSWGTQPATDPFSTPRSTAFQRGHSEEIHAQRNGKQSVEMKQIGQTLSNGGEHPTGLESQGRAVSMPRLAAETHPRSRAPSPGNGYLPSIPDTSPMKRSVSTLTPPQRAQLYEYSLERVPPERTHQHHHRCHRRKERKQKSTERSPQSEDADAPTRDRKHERGRSQERKQQPPSSSEKQRFYSCDRYGSRDSGHPRQCDHSRATSPSAGQDHSTHRQGSGSASGSPRLTSSGASTPCRGIRRQLPQTPLTPRPSVTYRTAHSSPVHFGGPAYSPGRLSRGLSEHNTLLYSDSPSHSACTVTRIGSDPYLGPRQDSDSYCPLSEETLTFEEALASNSGRSSRTSYVSSLTSHSHQLCRVPNGYHYTLGLSTGPATAPRGRSYYHEADEDDWC
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as CGAS. Acts as an inhibitor of cGAS/STING signaling by catalyzing lactylation of CGAS, preventing the formation of liquid-like droplets in which CGAS is activated.
Subcellular Localization:
Mitochondrion.
Domain:
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Sequence:
MAASVAAAAGRIRRAIRRSPPWQGLCFRALSSEAPPTQAAAVRDAFLSFFRDRHGHRLVPSASVRPRGDPTLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVANSQKCVRAGGRHNDLEDVGQDLSHHTFFEMLGNWAFGGEYFKEEACSMAWELLTQVYGIPEDRLWVSYFGGDPKAGLGADLESRDIWLNLGVPASRVLSFGPQENFWEMGDTGPCGPCTEIHYDLAGGVGAPQLVELWNLVFMQHNREADGSLQPLPQRHVDTGMGLERLVAVLQGKHSTYDTDLFSPLLNAIHQGCGAPPYSGRVGAADEGHIDTAYRVVADHIRTLSICIADGVSPGMSGAPLIVRRILRRAVRFSTEVLRAPPGFLGSLVPVVVETLGGAYPELHKNSAQIVSLVSEDEAAFLASLQRGRRIIERTLKRLGPSDVFPAEVAWSLSLSGNLGLPLDLVELMLEEKGVQLDSAGLARLAQEEAQHRAQQAEPVQEQGLRLDVHALGELQRRGVPPTDDSPKYSYSLRPSGGYEFSTCEARVLQLYAEDGRAVATTGEGQRYGLLLDRTNFYAEQGGQASDRGYLVRVEQQDVLFPVAQAQVCGGFILHEVVAPECLKVGDRVQLHVDEAWRLSCMEKHTAAHLLNWALRKALGPSTEQRGSHLSPERLRFDVATQAPLTPKQLQAVEDTVQEAVGRDEAVYMEEVALARTTHVPGLRSLDEVYPDPVRVVSVGVPVAHALEPASQAALQTSVELCCGTHLLRTGAIGDLVIVGERQLAKGTTRLLAITGEQARQAREVGQSLAQEVEAAAERLSRGSRDVVEAQRLSKDMGRLTDAVDTSVMPQWQRRELQATLKALQRRANTAIRKLEMGQAVLKTQELLQRHSEGPLIVDTVSAESLSMLVKVVRQLCKQAPSTSVLLLSPQPLGQVLCACQVAQSATPAFTAEAWALAVCSHMGGKAWGSRVVAQGTGSTADLEAALSAARAYALNQL
The following text describes a protein:
Function:
[Neuropeptide RFRP-1]: Efficiently inhibits forskolin-induced production of cAMP. Acts as a potent negative regulator of gonadotropin synthesis and secretion (By similarity). Induces secretion of prolactin; [Neuropeptide NPVF]: Efficiently inhibits forskolin-induced production of cAMP. Blocks morphine-induced analgesia.
Subcellular Localization:
Secreted.
Sequence:
MEIISSKRFILLTLATSSFLTSNTLCSDELMMPHFHSKEGYGKYYQLRGIPKGVKERSVTFQELKDWGAKKDIKMSPAPANKVPHSAANLPLRFGRNIEDRRSPRARANMEAGTMSHFPSLPQRFGRTTARRITKTLAGLPQKSLHSLASSELLYAMTRQHQEIQSPGQEQPRKRVFTETDDAERKQEKIGNLQPVLQGAMKL
The following text describes a protein:
Function:
Cleaves double-stranded RNA (dsRNA).
Sequence:
MQQQQHPAPGAEFVADRDAARAEVERALGGYSFRDGGALLLEDALTHSVHPRDEAGGRARHQRLEFLGDAALGLAFATIFYRDDPGLDQGDLTVLRSANVSTQKLARVAVRRRLYPLLRRYNCAPQDHEVSRFTKSVEGPYSGDPIEGPRVLADIVEAIVGAVYLDSKLDLEVLQKVAKLLCEPIITKKALLEDPESMLNELGGEHREDLEIKILAWRKVANVVDDGREQAITTSGLGNGSEDEVGKLRTIRIEEA
The following text describes a protein:
Function:
Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MEFKYLVFIVLCQYLDNTFFSETEAITTEQQSLSTLITPSLYVTTDSQNTAGNALSQTTRFKNISSGQQASPAQITPEQATPAVYVSSSPLTYNITRQAESAVNNSLPQTSPSGFTLTNQPSPSTYNSTGQPPKHLVYTSTQQPPSPAPTSSGKPEVESTHNQPTKSTPTIYLQRDTPPPPPPPLTSEPPSGKGTAHKNNHNAIAAILIGTIIISMLVAILMIILWKYLRKPVLNDQNWAGRSPFADGETPEMCMDNIRESEASTKRASVVSLMTWKPSKSTLLADDLEVKLFESSEHINDTSNLKTDNVEVQINGLSEDSADGSTVGTAVSSDDADLALPPPLLDLDENLPNKPTVTVVSPLPNDSINPQPSPDGLNQVCEEQHSKIQEPFPPPPDSFNVPLSAGDFINNQESAHEAQCQEFSTPDLHPDLTDSLPPPPTELL
The following text describes a protein:
Function:
Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane.
Sequence:
MLSRLAMRNGSAIASIALRSSAPCVSAAPQKMLLSTSTPQRMPNKMPEEAGKIRFGFVPEEWFQFMYKKTGVTGPYVFGTGLILFLLNKEIYVMGPETVHAAVALGLFIYGIKKLGPGIAEWADKKREETLADAYAGRNANIAAYKDAIEHEKTEQWRLDGRKQLFDARRENVAMRMEIEYRERLQQVAQAVQKKMDYHVELENTKRRLEQQHMVRWIEQNVVKSITPQQEKDIMSTCISNLKNLAPTA
The following text describes a protein:
Function:
Plays an important role in the elongation step of protein synthesis.
Sequence:
MASISELSCIYSALILHDDEVMVTGDKIKSLIHTASVNHEPFWPGLFAKALASVNIRSLICDVGAWWTCPSSRSCPIQLLPQLRRKLKQRKKSNDDTGFGFFG
The following text describes a protein:
Function:
Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as a docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAPPGHLLFLFLLPVAASQTNEGSCSGCGPLSLPLLAGLVAADAVMSLLIVGVVFVCMRLHSRPAQEDGRVYINMPGRG