lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.
Miscellaneous:
MISCELLANEOUS: Present with 2250 molecules/cell in log phase SD medium.
Domain:
Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
Sequence:
MSSGTENDQFYSFDESDSSSIELYESHNTSEFTIHGLVFPKLISVTSQDSEFDINEDEDGVDTIYEGMLDAPLTKNNKRILCEGSVPNLSYECLTTKGIFERMLQRVDHLQPIFAIPSADILILLQHYDWNEERLLEVWTEKMDELLVELGLSTTANIKKDNDYNSHFREVEFKNDFTCIICCDKKDTETFALECGHEYCINCYRHYIKDKLHEGNIITCMDCSLALKNEDIDKVMGHPSSSKLMDSSIKSFVQKHNRNYKWCPFADCKSIVHLRDTSSLPEYTRLHYSPFVKCNSFHRFCFNCGFEVHSPADCKITTAWVKKARKESEILNWVLSHTKECPKCSVNIEKNGGCNHMVCSSCKYEFCWICEGPWAPHGKNFFQCTMYKNNEDNKSKNPQDANKTLKKYTFYYRLFNEHEVSAKLDWNLGQTLGTKVHALQERIGISWIDGQFLSESLKVLNEGRTVLKWSFAVAYYSDASHNLTKIFVDNQMLLANAVESLSELLQIKTPEVIMKRRPEFYNKAGYVENRTTALMECGRELLCKGICKAAE
The following text describes a protein:
Function:
Chromatin reader that recognizes specific histone signatures to regulate transcription (By similarity). Plays a role in neuronal development.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MESTDSSDSSGDSLKSIPRPDFEALSAIGSPQPQLQSSSLDGHVEMEPVIMPSKRQKYIVSAPPGSANCSSNSSSSSPSNINVGSSLTMKLTKVQPQQHQAKSSTPNNKGKVAKEMVALQRSHIESEVLSNFVTGVSKLKSRKSRYVPGNLATQAVGGELSRSLNTSSENENKSLKVALKRSSSIPAPILDSDDDWQDEDIAWGVTTCRPRGRSMAFEDGERLANLNAEDRNIVPAYSMATRCRSRSKTLSLSNSWSNDDKGPRRSNLRSENEEFAKKHNAFLDRIIHDDRESELALNTSGEGESSLFSDASDTKTTTAKTPEEEAAERLALIYEEPPTPGWDPFCWKCRGCGKLMPCSKCLRSFHSYCVRPATTKFDSSWKCPECQVIEAAPKRLRRNGVSVDLLSQLLSFALDRMKHVRGAHKLRSPLEVFPLTYKKFFVNPVSFESLAQCIRNGAYQSTDEFLSEVKWIQHNALILDAGDAKVEQASKAVVKVCRQEANEIDTCPECYLNANSSDEWFVKVCRHPHLLLWAKLKGFPYWPAKAMGSSNSTLVNVRFFGKHDRAFVPVKDCFLYSAQNPNTQTSRRSARDLAECIREVEIHIDHIKRKIGAFNYAPYRTPYDPLEEQQQLEQMMPGVYAAIDRELEPANKTPLQFLIRKTADDKLSIVKKTKATESGNESDQSPSPTKKLSEVDVVSVTGSGCSDHSNVKSNNYEVISRSGESLTDSRCKVLLKRKSLAAKIVAESVETSEAVAPKRKHSLSDASFTSESSEHKRKSKHARKQHDNQDNQIEEAEKTGQEPPKSPTISKQNENLRDEENVIENAANDTSSASPVSASVVSVVELVRRRQGVTITKIPREQQQTAEDTAAVPIPLPTAPPPKQNIPKGNEAANPKQSDVERQQEQLIKKVIPFIEIKTEVMSEPDDEGIEEASPANQPQTDQVPLQQETITAQPESQMPAAAPAPQPKPVDNAPFEEVRIKEEILSEDEMETEQSIVSRRLKSVPPMPLPMPPPPPLPPREESPATADSVRFVGDTTIQRVSQKQGGKSTDTGGKRKGVQQVPIAGIPQAPSPTHSPLLSTAPSPSASPKPTSTLAVSKPPPPPPPKGKSASHLQFRGKNDRIPTSPPATAPPATNTSSLLRSNMVVIPVEQGGSCNAHSPMTIPVPPLRAVSKNTLQNTSTGSTSSCVPSSVSMPPPLAGLSIPPVATPTSQEESITNSGQPVGLLASALNGTANDVLSSDSIPNDPITPGLATALSEMLLHTGVPKLIARPRGALRSDGSQIYPSQAGPVSQKLKENAHKITDYFISVIEDTLSDMATGDQSVLQARIAGLSLENERLKQHYDRQINDLHRTSELMISEMRKTLEQEHKRVISELRQQNAIELMRAVEEAKRKQWCANCMREAQLYCCWNTSYCDYPCQQLHWPGHSATCGQSVPPTIPVPPSVPTPIIEPGRAKAKVATPTATPSITNPSPSSQIMRTVAACPSAPPSANASSSKKWPPMMTLMNQSNQEAMLKLPATTYLRPVVSTTMTAPVTAPQPANNNSTNVIMAPTPPPGNNLATIISAQRNPPNYNAKHPNPAMPVQRFNIPLPITVNSNAPFMMAEQHQKQVPKATGRSGKNNSRMRQTYSNNINNSNPQGMRCNNNPQAIRQNQMNQQVFQP
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MDADPPRLYAPPPGFTRLRLTVAWDGRDYAGWQEQRNAVSVQETLQTALHALGGEGALRPVSAGRTDAGVHAEAMPLHWDVPTTFRVPLVQLPRALNAWLPASVSVLSAEVAPAGFHARFSCTERRYVYRLWVAPQRHPLWAGRALHVPGPLDAEAMNRAAQSLIGLHDFAAFATREDRQTVRDLLRLEVQPQGELWDIHVAGESFLRHMVRGLVGTLLLVGQGKLGAAEVEGILASRERARAGANVPPGGLYFAGAEYGVRRVEGRSGNGGEPGTHRGR
The following text describes a protein:
Function:
Receptor for ATP that acts as a ligand-gated ion channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MALPPETFPGLEMCSLVTGRASTTGTRIRVKARGGSEQDVHGWNPRTSLASQHSTLCLFPYLQHKDDNRGVSRGCAKDSRNPYHREHLAGYVGLVIIICSPLLICKSSWTLTTGWVFLHEKAYQVRDTAIESSVVTKVKGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPQRFPGGGILTGRCVNYSSTLRTCEIQGWCPTEVDTVEMPVMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTAADMKTCRFHPDKAPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDRAWDQCIPKYSFTRLDGVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVDETTLKVTASANPVYPSDQTTEEKQSTDSGAYSIGH
The following text describes a protein:
Function:
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MEVSSRSSEPLDPVWLLVAFGRGGVKLEVLLLFLLPFTLGELRGGLGKHGHTVHREPAVNRLCADSKRWSGLPVSAQRPFPMGHCPAPSQLPSAKPINLTDESMFPIGTYLLYECLPGYIKRQFSITCKQDSTWTSAEDKCIRKQCKTPSDPENGLVHVHTGIQFGSRINYTCNQGYRLIGSSSAVCVITDQSVDWDTEAPICEWIPCEIPPGIPNGDFFSSTREDFHYGMVVTYRCNTDARGKALFNLVGEPSLYCTSNDGEIGVWSGPPPQCIELNKCTPPPYVENAVMLSENRSLFSLRDIVEFRCHPGFIMKGASSVHCQSLNKWEPELPSCFKGVICRLPQEMSGFQKGLGMKKEYYYGENVTLECEDGYTLEGSSQSQCQSDGSWNPLLAKCVSRSISGLIVGIFIGIIVFILVIIVFIWMILKYKKRNTTDEKYKEVGIHLNYKEDSCVRLQSLLTSQENSSTTSPARNSLTQEVS
The following text describes a protein:
Function:
Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones.
Subcellular Localization:
Vacuole.
Sequence:
MTTTLTLLLGFLALSSTLSFNAEARPQPSDEDLGIVIGPHTTFEDDLGIVIGPEESEDIPQVNLDDEDLGTIIGPEFEVHKSDFPDDFIFGTSVSAYQVEGAKKGSGRGLTTWDEFTHMFPDKVEQHSDGDVGVDFYTRYKDDIKLMKELKTNGFRFSISWTRVLPYGSIEKGVNVEGVKFYDDLINALIADGIQPAITLFHWESPLALEMKYGGFLSEQIVEDFRKFAKFCFDKFGDRVKNWATFNEPSVYSVAGYSKGKKAPGRCSPFEVIKCPSGDSSEEPYRVGRNQILSHVAAVEEFRKCKKCQEGGGKIGIVLVSHWFEPKDPNSSKDVEAARRSLEYQLGWFLRPLVYGQYPKEMLEGTTSRVEAFTPEESKRLRGSLDYVGINYYGAFFSTPLTNVNSSQITYHSDMRVNWTVDQNHSPHLKSTAMGIVIYPAGLMNLMRHIKDEYMDPEIYIMENGMDELDDGTKTLVEALNDYGRKEFIKSHILIMGKAIRMYNVRLKGYFIWSLMDNFEWEKGYKIRFGLYHVDFNDNMKRYMRSSGKWLSEFLDSKESLHKCYFEGHREKGYAPKLSDREIYDRDNWRIRYTSDVM
The following text describes a protein:
Function:
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
METRIVFHIDFDYFYAQCEEIRSPELKSKPVCVCVFSDRGGDSGAIATANYTARKYGAKSGIPIVFAKKRLEERKDAVFLPVDFDYYSEMSEKAMKIMEEFSDVFEYVGRDEAYLDVTKRTEGDFHKASHLAQQIKNSIREKTKLSCSIGISPNKLISKIASDFQKPDGLTIVSPEKVEGFLESLKIRDIPGIGKKTEQRFTEMNLETIGDVKRLDVFTLNKEFGRKSGTYIYNAVRGIDDELVKEREPSIQHGKIVTLKKDSKDYEFLLENTLELCKEVHEIIQKKNQMFKSVGISFVQSDLSNKTKSKMLRNPTMSLEELEKTVEQLLREALENQTATIRRLGVKVSELSESQGQRDITSYF
The following text describes a protein:
Function:
Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response. Also able to transport carnosine. Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand.
Subcellular Localization:
Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Sequence:
MPAPRTREQPRVPGERRPLLPRGVQGPRRWRRAAGAAVLLVEMLERAAFFGITANLVLYLNSTNFNWAGEQASRAALVFLGASYLLAPVGGWLADVYLGRYRAVALSLLLYLAASGLLPATAFPDGRSSFCGEMPASPLGPACPSPDCPRASPSPYCAPVLYAGLLLIALAASSVRSNLTSFGADQVMDLGRDATRRFFNWFYWSINLGAVLSLLVVAFIQQNISFLLGYSIPVGCVGLAFFIFLFATPVFITKPPMGSQVSSMLKLALQNCCPQLWQRHLARDHQGARLLPDQRSPQPGASPQEDIANFQVLVKILPVMVTLVPYWMVYFQMQSTYVLQGLHLHIPNIFPANPSNISMALRAQGSSYTIPEAWLLLANVVVVLILVPLKDRLIDPLLLRCKLLPSALQKMALGMFFGFTSVIVAGVLEMERLHYIHHNQTVSQEIGEVLYNAAPLSIWWQIPQYLLIGISEIFASIPGLEFAYSEAPRSMQGAIMGIFFCLSGVGSLLGSSLVALLSLPGGWLHCPEDFGNINNCRMDLYFFLLAGIQAVTALLFVWIAGRYERVSQGPASHSCFSRDRG
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MCQSDQQFLSPQEVFTSIELHTKNRDLDSKKYGFSNSSSVTDTLSEKYSLIVYNDQIRHFRDAVQRIHLASKKVPEFAEMVARRIQSHGRATVIRSKNVNVLFERQKLLNATGLSSCIRNARDEFREEMCLEIIQWLESISSCDLMKANELLRDLFCRAFCLKWNRGVLSDNAVLSRDENIAQLSGTFGLPRAFTREVKPGKWNIDSRSWDHINHLWEECGLVVKNIRKESNMDSRFQFLAYLDIRFWKAFRLALHTMYATTLITNLKWKGVICYQYCAVYPHISDMFLNLDGDPEMNVMCTLSCQLFISPSNSYAMLTKGDVTRIFRSIYGFLKTGHTHSSQLDSNHDICLASLKNRRWGQLFFDIGYIISRGQNYNVALNDEIIPMTCDLLSLFQGKPTMRREVLNHVEYENSDYTAFFHAIPVIYQLAEYIAQCFRNVPDHSRRRAVLEGAIFYVTRFILSLEFIIPKAKEHNEVDYGPVDSQNDGTQPLVSFLHPLHSFLSWLIEYTAFDDRDALITLFANVADNCSNFKSLTESVNTLFHYPIQSIALAAQVKTGYWVRNGFSVKNQYQLYKSTGLREQGFIRDIFLTQIYLICHDADMAINEILKIWLLNDDIGQCNDSYEATVLPYILDECLHFFLRIITEGLFMKRLTDHEIIQTKIEEEIIHQLCLGSMTYSKLCSQLPDHIVSERDFEIVLEKVADFNKPRSGKEAGTFSLKEEFYDKINPYYHNYSSNKKDEAVKIVKERIRKKTNQPLNEVVINPLSTRCARRGLFRYLGNFVTASKFVEFLSRCIHFVVLKKPEKFDGLFDTLLHVVHSSAMEINTDTKESFCSKSLDMALSGSASLVSLLYFALRKNEFLEHHAKIRAIFECFSEQVADFHNRMPHVVHGYDKRLLCDPSVIATENDFERKKRLAQQRQSKLMARFKKQQSSFLERNNLAAEYSDAEMEDTNSEGWNFPGAHCILCQDTAEDAGPFGLVVHISRSSEFRDVPFDDKYWFLKAFSDSCDLNKPSSDWAPEIQSEPFKKFMANNEEQCVIGPGFPSSGHVRNELVSSTCGHGMHFNCYVQFLASNRSRSNQITRNTPDSIDHREFLCPLCKALNNMFLPVLWSANNRSMRKFIKKDESKGDAFQTLTNADSHSGLWRKEFYNAALKDLKSFSILTCAATDVIIQNSDNSSSNEHQLFRILLSNMFQNLSLLTFPQILKADSSEILVNTIKSTEISLRGVRCTFGLVFQGISNNSLINLRALNEFRVTCLLMKVSYHVKSSLNKQDTQEKLLANLLCLSEERLSESIVDLDYFKLLVDVLPLPTAGFTFFEILNTCYIGHIVQCLFKISANIVEKRYFKNENFNILDVPFSSFITPEDSASAHYLFRELVKTGAFGFYSEDIMVSPQLGYVIFSMLLKSVTPFLRRASIYAFINCPSDCDLDHQAQHRNEADLLCSFFNLPSLNEILKRMAHENSSAFSKERRVFDNFTKFLEQNAATFADSSVLYRQLEYPGIVSLVRLPERLDDFFTRFYYSEKHDFPHLSVENPAICMFCADVKDLQRTALGSPHGQCNTHYKKECRNSVGIFLLPKERSLLLLSNNGGSFHPIPYLDSHFEVAGDNKKTKAVFLSSKRYEDFTKGLWLQHNISNYIVRRLDGVIDAGGWETL
The following text describes a protein:
Function:
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
SLLESLGAELVSILAPVSACMLFVVLLVRALVVNSSQLQAPAIALVIYAEDPSDSTSEKLGGALLNALVFVAFVTAATFLLVGLFYLRCTKCLRLYVSFSIFNVLVYLGAALGVLFVQTYSLPVDVITFSVVIFNFGVVGVLVAFPVMPVPIIFTQGYLVLIGMLTAFWFTFLPEWTTWFLLVAMALYDIAAVLLPGGPLNMLLELASKREEELPALVYESRPVVRPGQQGSQSRRWRRRVVVAASPSTSAETAPHVDHRMETLSAFMANEERAAGAIHDELRELNNDGSEGGELGRIESVTEGGIKLGLGDFIFYSVLVGRAAMFDLMTVWACYLAIVAGLGATLALLAVWRRALPALPISISLGVVFYFLTRLVLEPYVLQLDTRLVFF
The following text describes a protein:
Function:
GTPase required for the synthesis of 40S ribosomal subunits and for processing of pre-ribosomal RNA (pre-rRNA) at sites A0, A1, and A2. Controls access of pre-rRNA intermediates to RCL1 during ribosome biogenesis by binding RCL1 in a GTP-dependent manner, and delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEAKDQKKHRKKNSGPKAAKKKKRLLQDLQLGDEEDARKRNPKAFAVQSAVRMARSFHRTQDLKTKKHHIPVVDRTPLEPPPIVVVVMGPPKVGKSTLIQCLIRNFTRQKLTEIRGPVTIVSGKKRRLTIIECGCDINMMIDLAKVADLVLMLIDASFGFEMETFEFLNICQVHGFPKIMGVLTHLDSFKHNKQLKKTKKRLKHRFWTEVYPGAKLFYLSGMVHGEYQNQEIHNLGRFITVMKFRPLTWQTSHPYILADRMEDLTNPEDIRTNIKCDRKVSLYGYLRGAHLKNKSQIHMPGVGDFAVSDISFLPDPCALPEQQKKRCLNEKEKLVYAPLSGVGGVLYDKDAVYVDLGGSHVFQDEVGPTHELVQSLISTHSTIDAKMASSRVTLFSDSKPLGSEDIDNQGLMMPKEEKQMDLNTGRMRRKAIFGDEDESGDSDDEEDDEMSEDDGLENGSSDEEAEEEENAEMTDQYMAVKGIKRRKLELEEDSEMDLPAFADSDDDLERSSAEEGEAEEADESSEEEDCTAGEKGISGSKAAGEGSKAGLSPANCQSDRVNLEKSLLMKKAALPTFDSGHCTAEEVFASEDESEESSSLSAEEEDSENEEAIRKKLSKPSQVSSGQKLGPQNFIDETSDIENLLKEEEDYKEENNDSKETSGALKWKEDLSRKAAEAFLRQQQAAPNLRKLIYGTVTEDNEEEDDDTLEELGGLFRVNQPDRECKHKADSLDCSRFLVEAPHDWDLEEVMNSIRDCFVTGKWEDDKDAAKVLAEDEELYGDFEDLETGDVHKGKSGPNTQNEDIEKEVKEEIDPDEEESAKKKHLDKKRKLKEMFDAEYDEGESTYFDDLKGEMQKQAQLNRAEFEDQDDEARVQYEGFRPGMYVRIEIENVPCEFVQNFDPHYPIILGGLGNSEGNVGYVQMRLKKHRWYKKILKSRDPIIFSVGWRRFQTIPLYYIEDHNGRQRLLKYTPQHMHCGAAFWGPITPQGTGFLAIQSVSGIMPDFRIAATGVVLDLDKSIKIVKKLKLTGFPYKIFKNTSFIKGMFNSALEVAKFEGAVIRTVSGIRGQIKKALRAPEGAFRASFEDKLLMSDIVFMRTWYPVSIPAFYNPVTSLLKPVGEKDTWSGMRTTGQLRLAHGVRLKANKDSLYKPILRQKKHFNSLHIPKALQKALPFKNKPKTQAKAGKVPKDRRRPAVIREPHERKILALLDALSTVHSQKMKKAKEQRHLHNKEHFRAKQKEEEEKLKRQKDLRKKLFRIQGQKERRNQKSSLKGAEGQLQ
The following text describes a protein:
Function:
May be involved in splicing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPTGYHNFCDDELDESINFNYNRKPSQPKDYDDDSRTSGRTTPKRARGGRGRGSGDRGGRGGSRGRGGNGGSSRGGKKNGWRDEKPSLLSSILNSRQHASENREHMFNKSLRGAEFITFIKSAEVYDPSKLLKDVGVTVEEANVVNEVEDIHIIVPEVIPEVQDVTGADAQLEDQESEDEEVVTTITETYADDGDNQEDDDDEMLVDGNGQLVDDYDDDEDDDDEDDEIDEEVDDDLIADENAVDVSTLQDAINEVANDTINDDRKEEDPSEGSEADDEEDEAAEFVMDTEGDPDMVDMEFMETDFAYLNKKKRAEKSRTPLTSSTAVISDRPVASVSADTTLVGSVASKKRHNADPRAVDIPEYNSDIDPEVLKDYIESIKNEDEGSDAENIDWIRSALGTQLGGTEQYYVDSDDSENDDFDDDDEDDEEEYEWPENGTVGCIRNIVATRAASQGYQFMVEHTLDADMEEWWNEDLIRDSVAEHLGVSVSELPDEAYRWYVTRLGGDIEDPDLSEEGINYSDYYDDSDEDEKAREASEMDSLIQSLIDDEVDDRKALMDHGYTPPMTKSRGKNQVPNFGVNDPELQAQLEKHWVNSRAAKRAKREQRQAMRKQGMFTKEFKQGGIIPLHAKYPILMTVEEARKEIEIFINAPNKPMVLDFPPMGAEFRSVLKKLSACYHLKPDIHGVQKSKHVSMLRTSRTSCHNNNYIQKFHDKFPKKFKLVIRNAKYSTEQYLYETKHQKGSKRSAVRVHNREGEIVGHEAPAIDDSNIGRLLLQKMGWTTGEGLGAQSRGISEPIIAKVKISKRGIGA
The following text describes a protein:
Function:
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.
Sequence:
MTKSSGVFLDVDPTIVENNLRFATDANEEEFNKIFNPPGEQFPSKLVKPFPGFCIKTHEIGSDTKFFVNICHTDAIPAPKDISENELKDILNSDDAPNFRVPMSIGEIRNDKDKKGEDAKACDVAIHPTFFKKVEQSQLFKSFFVTIVFEGLKDKYGIICKDEKIILQNRKAFGNLQVHRVQQREIDEKMRSAKSPIEELRGNNEAPRGKPLIETISSNEMKCREPEYRLFRRKAKPNCLIGEFKFPDIVTKELTLDIGEDRIVIESTSKHYLLDVFVPLVIRQASCTSTFSKATKVLTVTMPLVGG
The following text describes a protein:
Function:
Virulence factor (By similarity). Involved in the degradation of glycogen of the mammalian host cells. Hydrolyzes the alpha-1,6-branchpoints of glycogen. Hydrolyzes pullulan. Does not hydrolyze dextran. Binds to mouse lung alveolar type II cells that are rich in glycogen stores. Is an alpha-glucan-specific carbohydrate-binding protein, which binds to amylose (pure alpha-(1,4)-linked glucose), amylopectin (alpha-(1,4)-linked glucose with alpha-(1,6) branch points), pullulan (linear polymer of mixed alpha-(1,4)- and alpha-(1,6)-linked glucose) and glycogen (similar to amylopectin with more frequent alpha-(1,6) branch points) in vitro. Does not bind to dextran (a linear polymer of alpha-(1,6)-linked glucose).
Subcellular Localization:
Secreted, cell wall; Peptidoglycan-anchor. Cell surface. Note=Localizes to cytoplasm in the lung alveolar type II cells of the mouse and human hosts.
Domain:
The N-terminal tandem family 41 carbohydrate-binding modules (CBM) are involved in carbohydrate binding. The C-terminal glycosyl hydrolase 13 (GH13) domain is involved in catalysis.
Sequence:
MRKTPSHTEKKMVYSIRSLKNGTGSVLIGASLVLLAMATPTISSDESTPTTNEPNNRNTTTLAQPLTDTAAGSGKNESDISSPGNANASLEKTEEKPAASPADPAPQTGQDRSSEPTTSTSPVTTETKAEEPIEDNYFRIHVKKLPEENKDAQGLWTWDDVEKPSENWPNGALSFKDAKKDDYGYYLDVKLKGEQAKKISFLINNTAGKNLTGDKSVEKLVPKMNEAWLDQDYKVFSYEPQPAGTVRVNYYRTDGNYDKKSLWYWGDVKNPSSAQWPDGTDFTATGKYGRYIDIPLNEAAREFGFLLLDESKQGDDVKIRKENYKFTDLKNHSQIFLKDDDESIYTNPYYVHDIRMTGAQHVGTSSIESSFSTLVGAKKEDILKHSNITNHLGNKVTITDVAIDEAGKKVTYSGDFSDTKHPYTVSYNSDQFTTKTSWRLKDETYSYDGKLGADLKEEGKQVDLTLWSPSADKVSVVVYDKNDPDKVVGTVALEKGERGTWKQTLDSTNKLGITDFTGYYYQYQIERQGKTVLALDPYAKSLAAWNSDDSKIDDAHKVAKAAFVDPAKLGPQDLTYGKIHNFKTREDAVIYEAHVRDFTSDPAIAKDLTKPFGTFEAFIEKLDYLKDLGVTHIQLLPVLSYYFVNELKNHERLSDYASSNSNYNWGYDPQNYFSLTGMYSSDPKNPEKRIAEFKNLINEIHKRGMGAILDVVYNHTAKVDLFEDLEPNYYHFMDADGTPRTSFGGGRLGTTHHMTKRLLIDSIKYLVDTYKVDGFRFDMMGDHDAASIEEAYKAARALNPNLIMLGEGWRTYAGDENMPTKAADQDWMKHTDTVAVFSDDIRNNLKSGYPNEGQPAFITGGKRDVNTIFKNLIAQPTNFEADSPGDVIQYIAAHDNLTLFDIIAQSIKKDPSKAENYAEIHRRLRLGNLMVLTAQGTPFIHSGQEYGRTKQFRDPAYKTPVAEDKVPNKSHLLRDKDGNPFDYPYFIHDSYDSSDAVNKFDWTKATDGKAYPENVKSRDYMKGLIALRQSTDAFRLKSLQDIKDRVHLITVPGQNGVEKEDVVIGYQITAPNGDIYAVFVNADEKAREFNLGTAFAHLRNAEVLADENQAGPVGIANPKGLEWTEKGLKLNALTATVLRVSQNGTSHESTAEEKPDSTPSKPEHQNEASHPAHQDPAPEARPDSTKPDAKVADAENKPSQATADSQAEQPAQEAQASSVKEAVRNESVENSSKENIPATPDKQAELPNTGIKNENKLLFAGISLLALLGLGFLLKNKKEN
The following text describes a protein:
Function:
CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC). The CzcB protein is thought to funnel zinc cations to the CzcA transport protein.
Sequence:
MGKKTIIAVTALALLGLGGGAYLELGGKAPAGAGEAAAEGEGSGPRGGMLLRQGDLTLELLVPEDGSPLKAWVERGGKALAPQEVVLGADVERATGEVEDLLFKASGDGLVANAGIAEPHAFTARLKLMAGKQGYDFAFTREEGKLELDAEQIEAAGITLDTARTISLAQVVSLPGEIRFNEDRTAHIVPRLPGIVDSVPANLGQAVKQGELLAVISSPQLSDQRSEFAAAQRRLSLAQSTYKREQQLWKEGISAEQEFLLARQGLQEAEIALNNARAKIAALGGNPSLQGGNRYELRAPFAGVLVEKHLTQGEPVDGTANVFTLSDLSSVWATFNVPAQLLGQVRVGSKVKVLAQALDSEVEGTVSYIGDLLGEQTRAATARVTLSNPESTWRPGLFVSVQVAEATRKEVLTVADGAVQNVDGEDVVFVRVADGFVVQPVKLGISDGQRVEVLEGLRAGSQVAASGSFILKSELGKGSAEHGH
The following text describes a protein:
Function:
Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLRGKATVAAAQPRRTFVLAGMLSLGQLVIGREARLADAMARGDLHNKNEDYQAKQLQELEARLQGLRNTRPSAPRYEGHVPLWWHEKALLFGISGLRSFFHPENGMNIVQLGEAAAIPCFLESLRRTMLSDATGRRILREQPNISEPDLDMDKLAQLPTNTLGHTFYRWLRKEGVTPDTRAPVTYIDDPVHAYIFKRYRQCHDFYHAITGLPIIIEGEIAVKALEAANIGVPMAALGALLAPLRLRAAQRERLRNIYLPWAIETGLSAKPLINVYWEELLEHDVDQLRAELGIRVPPDLRLIRQEQLQRRRSFKMKYESFEN
The following text describes a protein:
Function:
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Sequence:
MATEYERKRLENIRRNDEMLAALNVRANASILTAATKRPRDDSTKSYKKKEKQSKPETPIVMRKSLRTRGLDPDSVGLPNWFSDYPKRIPTPPHQYSSAPMQKSSARLLAPLPFDKAYDGEGSCKKFVEIMLGTTASKSMVKDDCDDSVGDSSSTRRRSSRLSNAVVQKEEPVSSSGFVKKEAFAKKSCRGKLVTKDENGDSPMSSGNDCLKKEVIKPEKIDFEKIEFDREPLSLEPHNVARVVPGRILVVKFMPCQNVKLVAAGDKLGNVGFWNMDCGVEDDDDDGIYLFRPHTAPVSSLVFQQNSLSKVISSSYDGLIRLMDVEKSVFDLVYSSDDAIFSLSQRPNDEQSLYFSAGYGMLYVWDLRAGKSVLNWDDLHEHRINSIDFSPQNPHVMATSSTDGTACLWDLRSMGATTPKTLKTVNHSRAVHSAYFSPSGLSLATTSVDNYIGILSGANFEDISMISHDNATNRWISTFRGVWGWDDSYIFVGNRPSKGIDVISTKLKRTVKELQDPLMKAIPCRIHCHPLNVGVVAGSTAGGQVYVWTPK
The following text describes a protein:
Function:
Protease involved in the processing of a variety of prenylated proteins containing the C-terminal CAAX motif, where C is a cysteine modified with an isoprenoid lipid, A is an aliphatic amino acid and X is any C-terminal amino acid. Proteolytically removes the C-terminal three residues of farnesylated proteins, leaving the prenylated cysteine as the new C-terminus. Hydrolysis depends on a farnesylated cysteine residue and no activity is shown towards geranylgeranylated peptides.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MISSYKYNPKLYFLSTFVVTYILWFTGAYLSFSSTYSGIYMLIMLPGLMAPFIISTILIAKSKNNELKKDFINRLFNLKLINLKTIPVVFLLMPAVILLSILLSIPFGGSISQFQFSGGFSFSTDFVPVLFLLLLAATFEELGWRGYAFDSLQSRYSLFKASILFGIFWSLWHFPLIFVNNSYQYEIFNQSIWYGLNFFLSILPMGIIITWMCLKNRKSIILAIIFHFLINLNQELLAITQDTKIIETGVLFLVAAAIILYDKKMFFEKLG
The following text describes a protein:
Function:
Histone methyltransferase that functions together with its binding partner LDL1/SWP1 as one of the regulators of flower timing in Arabidopsis. Mediates H3K9me2 deposition and regulates gene expression in a DNA methylation-independent manner. Binds DNA through its zinc fingers and represses the expression of a subset of stimulus response genes. May represent a novel mechanism for plants to regulate their chromatin and transcriptional state, which may allow for the adaptability and modulation necessary to rapidly respond to environment or developmental cues.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with euchromatic regions.
Domain:
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Sequence:
MEVKMDELVLDVDVEEATGSELLVKSEPEADLNAVKSSTDLVTVTGPIGKNGEGESSPSEPKWLQQDEPIALWVKWRGKWQAGIRCAKADWPLTTLRGKPTHDRKKYCVIFFPHTKNYSWADMQLVRSINEFPDPIAYKSHKIGLKLVKDLTAARRYIMRKLTVGMFNIVDQFPSEVVSEAARDIIIWKEFAMEATRSTSYHDLGIMLVKLHSMILQRYMDPIWLENSFPLWVQKCNNAVNAESIELLNEEFDNCIKWNEVKSLSESPMQPMLLSEWKTWKHDIAKWFSISRRGVGEIAQPDSKSVFNSDVQASRKRPKLEIRRAETTNATHMESDTSPQGLSAIDSEFFSSRGNTNSPETMKEENPVMNTPENGLDLWDGIVVEAGGSQFMKTKETNGLSHPQDQHINESVLKKPFGSGNKSQQCIAFIESKGRQCVRWANEGDVYCCVHLASRFTTKSMKNEGSPAVEAPMCGGVTVLGTKCKHRSLPGFLYCKKHRPHTGMVKPDDSSSFLVKRKVSEIMSTLETNQCQDLVPFGEPEGPSFEKQEPHGATSFTEMFEHCSQEDNLCIGSCSENSYISCSEFSTKHSLYCEQHLPNWLKRARNGKSRIISKEVFVDLLRGCLSREEKLALHQACDIFYKLFKSVLSLRNSVPMEVQIDWAKTEASRNADAGVGEFLMKLVSNERERLTRIWGFATGADEEDVSLSEYPNRLLAITNTCDDDDDKEKWSFSGFACAICLDSFVRRKLLEIHVEERHHVQFAEKCMLLQCIPCGSHFGDKEQLLVHVQAVHPSECKSLTVASECNLTNGEFSQKPEAGSSQIVVSQNNENTSGVHKFVCKFCGLKFNLLPDLGRHHQAEHMGPSLVGSRGPKKGIRFNTYRMKSGRLSRPNKFKKSLGAVSYRIRNRAGVNMKRRMQGSKSLGTEGNTEAGVSPPLDDSRNFDGVTDAHCSVVSDILLSKVQKAKHRPNNLDILSAARSACCRVSVETSLEAKFGDLPDRIYLKAAKLCGEQGVQVQWHQEGYICSNGCKPVKDPNLLHPLIPRQENDRFGIAVDAGQHSNIELEVDECHCIMEAHHFSKRPFGNTAVLCKDISFGKESVPICVVDDDLWNSEKPYEMPWECFTYVTNSILHPSMDLVKENLQLRCSCRSSVCSPVTCDHVYLFGNDFEDARDIYGKSMRCRFPYDGKQRIILEEGYPVYECNKFCGCSRTCQNRVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCSYILDIDANINDIGRLMEEELDYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPLAHIGLYASMDIAAGEEITRDYGRRPVPSEQENEHPCHCKATNCRGLLS
The following text describes a protein:
Function:
Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
Subcellular Localization:
Nucleus.
Sequence:
MTLSEKFGAVYDDNEELKKECANIMSIFNLSEEDLFIKWECFAINTNGDEKTDLDLGNLSKLKTYLLKEIEKAKKAKTTTPRPKMRRNREGAGDMDLFDQLTHSALGSAKRGPAGGDNDQTPVKKRPQPNGTGNGLSMSPPLSVTPIRSTPPPPSNSAYSSRKGAGTVMETLNSSIELNPGRADPETKIAISDHVQSAKYKYKTMYQKVSEASETLDEQIEQYMDWCVQKGLVKSNAEFKNPSLSDQNSIVCAGRIVLDTPETVRLTDASVLLETPRSRGGALRVKLNLSLLPSVSLIPGQLLALKGVNSSGREFVVEEILKLDPPPFRQVDNVAETPSLTQIIAAGPYTTTKDLDFLPLKDLLAQPADTFILLGPFIDSVHPLVAQGSFSVPGKMVATVEDLFRHKIAPLLNACPAQIILIPSTRDSVSAHLAFPQPALARKALNLGKNVICRTNPAQFSINELMFGTANLDIVRAVAQSELNKGSQEDFMSRAGRYVVEQRSLYPLLPGPQAKQPGVAEENQTLTYHHLDKAYLGLCDFVDVSPDIIIMPSQVQAFVRVVNSIVIINPGYLTRMDSGGSYALLTSAPYQGGDAKAWERVRVDIKKI
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MRTQIHNAPNDAMTTHHLRKPIKPIKLPCCSSSNKPKFLFLISMASFLFLALLSLTIFLSLTSAARNHQPPRSHVISPNPQIQQACKATRFPDSCQASLAGLVTNPNTTPIQIIQSAIQVSTDGLQTAQKMVKSILDSSAGNENRTTAAKNCLDVLHNSEYRISLSTDSLSRGSIRNARASMSAALLYQYDCWSALKYANDTQMVNQTMSFLDSLTGKSSNALSMMFSYDNFGNDTKSWAPPKTERDGYWERVEGGGSGQEVRFGVPSGLKADVTVCKEESEKCYRTVQEAVKAAPDNAGAKKFVIRIKAGVYDEIVRVPLEKRNVVFLGDGMGKTVITGSLNVGQPGISTYNTATVGVLGDGFMASGLTIQNTAGPDVHQAVAFRSDSDLSVIENCEFLGNQDTLYAHGNRQFYKSCNIQGNVDFIFGNSAAVFQDCNILVRPRQQKPEKGENNAVTAHGRTDPAQLTGFVFQNCLINGTEEYMKLYRSKPQVHKNYLGRPWKEYSRTVFINCNLEALITPEGWMPWSGDFALKTLFYGEVGNSGAGSDLSKRVSFSSKIPSERVNTYSVQNFIQGNEWIST