lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSLLYHEKQVAALCGVHTLNTLLQGPYFSEIDLAQIAHGLDALERELLGDAMGGEASGNVAMDGMFSIQVLSRALESWGLTVMSLESEEARDLKAAPTSAEAFICNLQEHWFTLRRVADGEWWNFNSLFPAPQPLSTFYLTAFLDTLRGEGWTIFVIRGKLPATQPGGLETLPNAGKWWTSEDARAATDEAERARKRGRVTNALETALARAGEQGGSLQLRTRGTPAAAAAGGDDDEDADLAAAIAASLQQGGAAAGPGPGSQALAVGGGPAASGLGTAAGDAALEQEHGPGLGEFEDEDPELAMAIAASLADQPGPAGAGAEPSSAAAGGGPGAAAAASGSGQAAPEPEVPEVELQPEPEEGAEGAIELAFRLPSGGRCSRRFLTSQPAACLAAYLAPQLGVTPGRVAVATQFPRKELPLRADAPLSELGLTHRTMLLAEARK
The following text describes a protein:
Function:
Probably involved in transport through the plasma membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
IVTKRKCRDIIFLILFILYWIGMAFVAQSAISSGDPRRLLTPTDYLGEFCGMNNTVLNASLSDLSTKPYLYYLNPVELNYAVCIASCPNITIATVTPSTGICIYSATPSILNYTSYMSDQTCSSYIYKSTPVLGRCVPIEPIPSVYVNQTFTAGNATISTNAILTAGRSYAVQAVTDLWSTWPVIATFIAIALVLCFLWLIFMQWMAGIFVWTVILLSNVIMIGVSVWLYYYWQGRLKDYNNSGSSSSNSTTSYSIGGQILSAKNEVVASEVIFIVCAVVAGLLLLITIAIFKRVRIAIQIIKESSRALLTMPLIVLFPMWIYSGLILLVVYFIGVMLYLLTPSGPVRISAFGLTITDPNISNQMIWYHLGGCIWFFTFLSGINQITLAGAIAQWYWTLNKKELQHLPVLHSFYRVCRYHLGSVALGSFLLTLIEMVRIVLWYIQRQAQKTHNQTIQYIVACLQCCMKCVEMLMKFINKNAYIYIAIKGKAFFKSAAEASSLLLRNALRLVAVDFVADFILIISKLGVTTLCGFLCYLWFSYQAAQYTNVKFPFITVMVVVVEAYMVATAFFSIYHMAIDTIFLSFLEDCETNDGSPEKPYYMSDTLKRIV
The following text describes a protein:
Function:
[Isoform Short]: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis (By similarity). In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE; [Isoform Long]: Does not generate Lewis X antigens.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Sequence:
MRRLWGAARKPSGAGWEKEWAEAPQEAPGAWSGRLGPGRSGRKGRAVPGWASWPAHLALAARPARHLGGAGQGPRPLHSGTAPFHSRASGERQRRLEPQLQHESRCRSSTPADAWRAEAALPVRAMGAPWGSPTAAAGGRRGWRRGRGLPWTVCVLAAAGLTCTALITYACWGQLPPLPWASPTPSRPVGVLLWWEPFGGRDSAPRPPPDCRLRFNISGCRLLTDRASYGEAQAVLFHHRDLVKGPPDWPPPWGIQAHTAEEVDLRVLDYEEAAAAAEALATSSPRPPGQRWVWMNFESPSHSPGLRSLASNLFNWTLSYRADSDVFVPYGYLYPRSHPGDPPSGLAPPLSRKQGLVAWVVSHWDERQARVRYYHQLSQHVTVDVFGRGGPGQPVPEIGLLHTVARYKFYLAFENSQHLDYITEKLWRNALLAGAVPVVLGPDRANYERFVPRGAFIHVDDFPSASSLASYLLFLDRNPAVYRRYFHWRRSYAVHITSFWDEPWCRVCQAVQRAGDRPKSIRNLASWFER
The following text describes a protein:
Function:
Mediates the uptake of pyruvate into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MATTKLQALWNHPAGPKTIHFWAPTFKWGISIANIADFQKPPETLSYPQQMGITLFSYPSCSCVRHYIVFSHLLTVCLLNIIPVITGTGLIWSRYSTVITPQNWNLFSVSLAMAATGIYQLTRKVKHDYASETDHVVARE
The following text describes a protein:
Function:
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Seems to be the major FBPase of M.tuberculosis and to play a key role in gluconeogenesis for conversion of lipid carbon into cell wall glycans. Does not display activity against inositol 1-phosphate.
Miscellaneous:
MISCELLANEOUS: Gluconeogenesis is critical to M.tuberculosis ability to establish infection and is necessary for its survival in the host.
Subcellular Localization:
Cytoplasm.
Sequence:
MTAEGSGSSTAAVASHDPSHTRPSRREAPDRNLAMELVRVTEAGAMAAGRWVGRGDKEGGDGAAVDAMRELVNSVSMRGVVVIGEGEKDHAPMLYNGEEVGNGDGPECDFAVDPIDGTTLMSKGMTNAISVLAVADRGTMFDPSAVFYMNKIAVGPDAAHVLDITAPISENIRAVAKVKDLSVRDMTVCILDRPRHAQLIHDVRATGARIRLITDGDVAGAISACRPHSGTDLLAGIGGTPEGIIAAAAIRCMGGAIQAQLAPRDDAERRKALEAGYDLNQVLTTEDLVSGENVFFCATGVTDGDLLKGVRYYPGGCTTHSIVMRSKSGTVRMIEAYHRLSKLNEYSAIDFTGDSSAVYPLP
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MGLMKQAYNSLFRRSSTFLFTIVVGAVLFERAFDEGLDRVWEKRNEGKLWKHVKAKYVTEE
The following text describes a protein:
Function:
Involved in promoting potassiumm ion uptake.
Sequence:
MEGFTLETHASRIIEVPLLGQEDQSVEIDCSSLPSDATELCEILVNEQAPREFWTKFAHEYYIRGLREQAILILKSGLETLKDSESLCILNANIAAIYLSMAREAMLKKDTDLRDEQLRNVRTYLEAANNIDSKSEINVLLHGIYRILLNPTDKESLENAARCFDFVLQKSGGNILGFLGKARILYAKGNYRSALKLYQRALVSNPQFKPDPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLYYYDLAFQNVNNDSFVQNYGKALQHIQRAFKTRNNDPVASSILERYVYSKKNYEGCIKLAENVIQNSFSSSLIADGYYWMGRAYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAKLTFERIAEQNQSCFEALVVLGCLHASDSKPDLTKARMLLDRAFNLVGSSKLPRVVDSDLYITQARLWEKEDTKKSLGFLTRALDFLESAHMSVGPELLNNIAVLQYHLGLIPEAHGNIIKAKSVLPDANPELSLLLDYNLARCEEELGNTSVASEAYVSILEKHPSFIDARIRKCLLQLSNPNEETFKEIRHIMNADSQNLEVRAFFGWYLSKQKRRPVEDPEVRHCSQTLRHWHDDIYSLVQLGNAYMRQAREFRVHNDREKLKRQKLYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKVREAIKDATTLINIGNCLAELKQFSRAIEVFETVYSSTGESDTYGVLSCLGRVWLQRGRESKNVDYLKESVRYATLALEKNPENPSLLFNVAFVQFQLCELIRQKPENSRTVEDLNFAMQQLDASIETFTKLVSVEHPPYSPTSIEQRAKMAKNTTKRQLERAIQAQIEYEKSVAAKLEDARIQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEEVLEWRKSQQKASEDDMSLSDDEEKQSGKKKKKDRKKRKSKSKQESSDSGVSEDDEIPLSDARNKTKKRRVNRRVISEEYTFDQDSDAEGNQEEEVSRTIEEKQDNDITDNQDDNKELNLFSEEDEE
The following text describes a protein:
Function:
Regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Functions as a part of 2 distinct protein complexes TORC1 and TORC2. TORC1 is a rapamycin-sensitive complex that controls cell growth in response to nutrients and growth factors. The second TOR complex, TORC2, is presumed to be indirectly negatively modulated by rapamycin and regulates actin polarization. TORC2 but not TORC1 negatively regulates phagocytosis. TORC2-dependent regulation of the cytoskeleton may follow differential phosphorylation of pkbA. May have some protein kinase activity, as it appears to phosphorylate pkgB.
Sequence:
MSQHEQPSIWADALTKLLNDLKSKKEEDRVKASKNLKSYVISQSREMTNENFTKFMNELNNNLIFELVNSSVIPEKIGGIMAIDELIDVDYDENATKITRLANYLRIGLGFNDFTVMLMASKALGRLARSSGTLTAEFVEFEVTRALEWLSGDRIEARRHAAVLVLKELAQNAPTLFYVHASSFVDLIWVALKDPKVAIREGAVEALRACLELISERESRLRLQWYQKIYDEAQKSFKQNGSPESIHGSLITVSELLRNTGDFMLSKFKDICETVLKYKDHRDKLVKKTVLALFPRLAVFCSRDFVLNYFNACMNHLLAALRNQNERPTAFIALGEIAMAVGGSIKPYLDSIVVMIKQGLMTKGKQFCPEVLTCISMLASAVGQSMYPHMQVILPQMIVSSGLTVVLTDALRDLTINLPTLIPNIQYKLLNLISQVLANKPFSEPGAPSPYRKSATPFQGGSIPQLGQNSDVDPQMIALALKTLGSFDFSKHNLLEFVRECVVNYLDDDNIEIRREAAITCAQLMVGTEEPTPTRGHSAVIVGEVLEKLLVVGIADPDPSIRKTVLSSLEARFDHYLAQAENLRSLFIALNDELFEIRELAITVIGRLTIRNPAYVMPSLRKTLIQLLTELEFSGDGRNKEESARLLGHLISASEKLIKPYVEPILKALLPKLRDSNPRVASCVLAALGELSVVGGEEMVQHIDSLLPLIIDTLQDQSSTSKREVALKTLAQLASSTGYVIKPFSKYPMLLDTLLNAIKTERIGSIRREVIKVLGILGSLDPYKHKMNELGKRREDPKANDDKNNNMTNEVITISPSNEDYYPTVALTALMKILRDPSLSSHHTSVIQAVMYIFKSLSLKSIPFLPQIMPPFLHAMNTGEPLFREFLFQQLGSLVSIVKQHIRDYLVNVFALIEKYWNSNLLIPIIKLVEEISSALNDEFKVYLPNLIPQMLNVLHTDRSPKRSPTTKVLRALEVFGTNLDDYLHLVIPAIVKLFEQVDVTTQVRTLAIQTIGRLCKKLNFSDYASRIIHPLARVLDSTESELREETLNTLCALVYQLGSDYAIFIPMVGKVLARREIQSTNYELLISKLLKNQQLMLTPGSGDDGGMGANRFGGDHNGHHLGEDHNNTSTPLDIGVKKLKANEQHLKNAWETSQRSTKEDWGEWIRRFSVELLRESPSPALRSCLSLAQDYHPLVKELFNAGFVSCWTELHEQFQEELVRSLETALLSPNIPPEILQTLLNLAEFMELHEKPLPIDIRTLGALAEKCHAYAKALHYKESEFSQSPSSTIEALISINNQLQQPEAAIGILIYAQKNHSVELKEGWYEKLRRWEDALAAYEKKQKDDPNGGTIENTMGILRCLHALGEWERLSALSSETWKSDINDHTRATIAPLAAAAAWNLVNWDKMDEYVCAMNKDTVEGSFYRAILEVHHDNFTLAHGFIDHARTLVDTELTALLGESYNRAYKVVVRLQQLSELEEIIEYKKCVDSPERRNMIKNTWKTRLRGCQHNVDIWQSILAVHSLVISPHEELDMWLKFVGLCRKGSRLGLAQKTLTMLMGKDPSTTSQFGSVLPNTHPRITFAYIKQLWSAGAKQPAFEKLRTFVQALRDTDDLPLQGRAYLKLGEWQLALGDTLSEASIPHIISSFKAATECDPNWYKAWHSWALINFEVVSHYEQNGGTPEQIGAHLLPAVHSFFKSISLGPDRSLQDTLRLLTLWFKHGAQKEVEAALMQGFNTISIDTWLHVIPQIIARIHAPVLPVRRLLHELIDTIGKEHPQALVYPLTVATKSHSPARLAAAKSLMDKMRKHSATLVDQALPVSQELVRTAILWLEMWYEGLEEASRQYFGDHNPEAMLATLAPLHQILEKGPETTSETSFLQAFGRDLQEALEWSKKYEKTRKEGDLNQAWDLYYQVFRRIYKQLPQMSSLELQYVSPKLLNSNNMELAVPGTYKASENVIRIQSFSQALSVIPSKQRPRKLTIIGSDGLEYTFLLKGHEDLRQDERVMQLFSLVNNLLSANHETAKSHLSIRRFSVIPLSPNSGLIGWVPHSDTLHTLIKDFRDSNKILLSIEHRLMLQMCSDYDNLTLLQKVEVFQYALENSNGLDLHKVLWLKSRNSEVWLDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRHTGHILHIDFGDCFEVAMHRDKYPEKIPFRLTRMLINAMEVSGIEGNFRLTCEAVMNVLRNNKESLMAVLEAFVHDPLINWRLLTPNENNTKHKATNIASNNSTSNSTTKIEGDLNTIDNPINKESPDHEAVAGSLKSSPVHGRQIARNQRVGVDAEQVEAEIVPEALNERALSVINRVNKKLTGRDFSSNETLDVPEQVQKLIDQATSHENLCLSYVGWCPFW
The following text describes a protein:
Function:
Plays a role in resistance to host antimicrobial peptides such as protamine, RP-1, or human beta-defensin-2; allowing colonization of human tissues. Required for resistance to membrane permeabilization and maintenance of mitochondrial membrane potential upon exposure to RP-1.
Sequence:
MSSSQDYNNNSNNTPARVSSRKGKNLHVAHRRSPSELTNLMVEQYNLQRQLEEVQAQQKLLEEKQKQQQQQFTYPSAQGSSELAPPPISSGYGGNRSSHSRSSSINTHRRTGSGSGGTAHGHSRRHSLGLNEAIKAAANQKQSNRNSLSPTIPNEAKTDSSDDIGSFKFPPSGGDQGDTSGQSSSSHNRSRSLAYGQQSFKFPPTPDQSNDTRGNSLLPPNPNFSVTQSPDRGHNRRSSHFRTGSRGSGSNTNTDGINSNWRAQQQSPQQQQRQGGLLEPPQVGFTPGHKPRNSSYGGGSSVSSLQQFLPNNGGSNNSGQQGGHQGGGNNGRKTLFAPYLPQSSLPELINEGRLVTGTLRVNKKNRSDAYVSTDGLLDADIFICGSKDRNRALEGDLVAVELLIVDEVWESKKEKEEKKRRKDNTLHSRPLTDDIHNDATSAPNTAEGSVTGTSKEDGAGSNEEETGGLARRGSLKQRPTMKKNDDVEVEGQSLLLVEEEEINDEIKPLYAGHVVAVVDRIPGQLFAGTLGLLRPAQAAQAARDKKNGKESTVQNPKAPKIVWFKPTDKKVPLIAIPTEQAPKDFVENHEKYADRLFVASIKRWPITSLHPFGTLVSNLGPIDSPETEIDSILRDNNFLCDEYPDDDNDDIVSVNAYDLPSIEPEFENTQREEYLNDYIIAFTQNGEFVDHALHVKRISNTKIELGFHVADIAYFIKPGSSLDRKSKKRSSSVFLPQKTVNLFPKQVNKIVSFKENEKNLAVSVVFEIDTSNFEVEDLYIHESVIVPKQLVTYDAFDTILSGQSVDSISSATSDYVKTFSLIAKEFRRHRLSNRSLGITPNLTLLDQLDDEKVRLDLNIFKDSLAFDVISEISHKVNSAIAAKVHAGLGDQAILRRHPLPTLQKMETFVRKATSLGFKIDTTTSSTLQNSILKIDDPVKRKCVETLLYKCMSRGRYYVAGKQDTDSYAHYYFNLPLYTHFTAPLRRYADLIVHRQLKAVLNKQVEDKDLDSLKAITDYCNFKKDCAANAQEQAIHLLLSQTINEMSETAGQLLCMGTVVQVYESSFDVFIPEFGVEKRVHGDQLPLVKAEFDKNERILELWWEKGVDSATYIPPDEKSSLSYRNSIKNKYRTSALQAAKIQSKTALEKSTTPADSVAEKLAKLNLEPPKLVVPSLKSNELHEVEKDETKSMPSSPTQSEIPKNVRTNSSSRISSSGNTFSLEPYLQNTITRIEGDSYIQVIKELTQVPVLLRAEIGMALPCLTVRVLNPFAEEQ
The following text describes a protein:
Function:
E2 ubiquitin-protein ligase that mediates E1-dependent protein ubiquitination. Mediates PHO1 degradation through multivesicular body-mediated vacuolar proteolysis in response to inorganic phosphate (Pi) availability. Negatively regulates the protein abundance of PHF1 and PHT1s under Pi-sufficient conditions by facilitating the degradation of PHT1 proteins at the endomembrane. Functions cooperatively with NLA to regulate the abundance of the inorganic phosphate (Pi) transporters PHT1-1, PHT1-2 and PHT1-3 in different subcellular compartments. Regulates Pi homeostasis by mediating, cooperatively with NLA, polyubiquitination of PHT1-4 and its targeting for degradation.
Miscellaneous:
MISCELLANEOUS: MicroRNA399 (miR399) can be sequestered by IPS1, a non-protein coding RNA containing a motif with sequence complementarity to miR399, but with a mismatched loop at the expected miRNA cleavage site. Thus IPS1 mimics the target of miR399 to block the cleavage of UBC24/PHO2 under Pi-deficient conditions.
Subcellular Localization:
Golgi apparatus membrane. Endoplasmic reticulum membrane.
Sequence:
MEMSLTDSDWDSSSDSGSSEHEEVEFSYGGRAQNIFSNLEETIGKIDEFLSFERGFMYGDIVRSATEPSGQSGRVINIDMFVNLESTHGKIMKEVDTKRLQKLRSISLSDYVINGPWVGRVDKIVERVSVTLDDGTNYEVLVDGQDKLVAIPPNLLEDSQYSYYPGQRVQVKLAHAPRSTTWLCGTWRGTQVMGTVCTVEAGLVYVDWVASIVMEGDRNLTAPQALQNPESLTLLPCVSHASWQLGDWCILPGSSHCDIAERQTPNVAAYNLNECHKTFQKGFNRNMQNSGLDELFVITKTKMKVAVMWQDGSCSLGVDSQQLLPVGAVNAHDFWPEQFVVEKETCNSKKWGVVKAVNAKEQTVKVQWTIQVEKEATGCVDEVMEEIVSAYELLEHPDFGFCFSDVVVKLLPEGKFDPNADTIVATEAKHLLTESDYSGAYFLSSIGVVTGFKNGSVKVKWANGSTSKVAPCEIWKMERSEYSNSSTVSSEGSVQDLSQKISQSDEASSNHQETGLVKLYSVGESCNENIPECSSFFLPKAAIGFITNLASSLFGYQGSTSVISSHSRCNDSEDQSDSEVLVQETAESYDNSETNSGEVDMTTTMVNIPIEGKGINKTLDSTLLENSRNQVRFRQFDMVNDCSDHHFLSSDKGLAQSQVTKSWVKKVQQEWSNLEANLPNTIYVRVCEERMDLLRAALVGAPGTPYHDGLFFFDIMLPPQYPHEPPMVHYHSGGMRLNPNLYESGRVCLSLLNTWSGSGTEVWNAGSSSILQLLLSFQALVLNEKPYFNEAGYDKQLGRAEGEKNSVSYNENAFLITCKSMISMLRKPPKHFEMLVKDHFTHRAQHVLAACKAYMEGVPVGSSANLQGNSTTNSTGFKIMLSKLYPKLLEAFSEIGVDCVQEIGPES
The following text describes a protein:
Function:
Putative ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDGVCKSPQRLLFVLVSCFGLVQSYKNGLVSSVCGSMMPNHGANAQISSPPFTVTADKTTFKEGDQITVTLNSQTGYQFEGFMLQARQVGSSSSIGTFSVTASNMQLLTCDGVSARSVSHTSNSKKSSIQAKWTAPTSGQLGNIQFSVTFVKSDDTFWVGVKSSAVVYNGAGTTGTSTTPATVAPTVASIPGCGTTKVCFSQPNNCDPTTSTGCYFVAVQASSDQSEMRIEMFGPADGYVAIGFSDDQQMGNDDVYICGKDNNGNLQVQHAFNSGRSRPAILSLGNVTDILTAVTNGNINCSFISRNTISTASRAATTNEYYLMIAAGSSSQGNIQFHTNKYVTSTKVNLLNPSVVITSEEEFPPMVKAHGCLMLISWMATGSIGMIIARYLKGVAKGQGCFGKDFWFVAHVSLMTLSIIATAIAFIIVFVSAGDWAGGAHPVLGCLVMILSLIQPIVAAFRCEPQHERRFVFNWAHSCNAFAIKCLAVAAIFTGLALFEEYDSDGWMLKVMGGYLAWEALMYILQDLNLRAKKKDSQLCSCEPMRPETILLFLFIIGNLAFLIALLVGIGSA
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Subcellular Localization:
Nucleus.
Sequence:
MYQNGKPDAPTILGQKRELEDVEIQDDDIQEVSKEDLLKDVRVRSIQFDELESKIEGLQNLAEEKLKVLATLVSWWPEILQQFSVVFQGNELKDFESEGVFSILEKFPELSYFNDAVKNNKTKALSIIQKLLSTVDSSTNSVSRDPFSVLSIDDSALTEKLNTINLDIDKILDELDTTRSQLHSIIKLPDRSSSFTLQCINESVRPQSTKVKEEATTSSKGKDEEKKVSTVEQRTQLQQLSRLQDQQNGLMESRSQSLKILDSNVNEMDKLIMERENALNNVETTNLKKYSSFLALKEAVSMTSEQLRVLEHLLSECSHEINVLSQQSKNFNGVFESSYQPLINDLDHQISVMQNDEKRINNAKTELSLSLEKKLEAKKQKEKVYKDKLDELANLETMVLEKKKAVATREAANKIRLVDLNDLELQKDLSTYLSKELASTEKAFRLVKQQTVKSSHSHYQELITKFSVEKEKAEQKYFLTMKSTDSLHAEVKLLRQKYQKTNEIISKMLNSQDTAVHRIIEFEDQLARLSSVRNNSIKQSTTFQVKKSSQKSTIQNLEEKVSYLQQFMDKNNATLTDLEFQCSDLSSSIDILSKQDEEHEKEKRKLKDTGVSTSAEELKTFRAMCKCSVCNFERWKDRIISLCGHGFCYQCIQKRIETRQRRCPICGRGFGASDVIPIHL
The following text describes a protein:
Function:
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSNVTENKHDLHENGVPDSAQPMELDVSKKEDTEPEVRDEAKEFLLSQLPQVEVPEWAQWFDFSKVHEIEKKQNPEFFDGKNTSKTPEVYKEYRDFMISTFRLNSKVYLTFTACRRNLAGDVCAVLRVHRFLEQWGLINYNVNPDTRPSKIGPPSTSHFQILADTPRGLVPLLPPPSSSIPRSKAVTIEDPSIVRTNIYDPSLDDVLKGKGSTPNQKPSLSNLHENNIDQSDSPQHCYCCGNKFNESYYQSQTAQKYNVCISCYQQNRFPSPTTIADYKEVAIQNKIEDDDTWTAQELVLLSEGVEMYSDDWAKVASHVNTKSVEECILKFLNLPSSDKALFKMDKVHTNPVVDSLQGKNPILSVVSFLAKMVPPSSFTQKSSAKEEESDKVKGESVYPKPESESYDVEMNGKSLEDSDSLSELYLTNEEKKMASIIKDSVNVQIKLIESKLSHFDYLDQHIRLKSQELDAFAQATYREKLYMKRECQNARKKIEQQLQSKDTAANGLPVQSSAETSVIPASSMSPS
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MDIELFLSNYNIANGTSSTTANNSKFQPKIKVKLVVESGSSTYEKSLESTNDQLKPLIIKLNNKIKKYEESLNKKNFVTPNKQSSSSMNLLQKSSTVNLSSPSLSQIGLTHHASLKNLQITTSPDIQQPPSVPSNPIVFGISLDTLIAKEKSMELRIPTFVSNILNTLFLHSLGVEGLFRISGSQMEIQNRRGIVNLGDYSTSRDDNPHVLTVLLKQFLRDLPEPICTNALYDLFLAASDQINFQQCKENGFEVLKKLINSNLPVNNRNLLQHLIHFLRFVAMNQTVNLMGPSNLSRVFGPNLFWKKETGPLDIQILQSTSEKVNFITEQMILHYDTLFEEPLQTTSPAVLSNTPINSNPASIPTFNFGGKKLVIHSKLLGHNKSIQWMTLCGSSNSNGNSELSGSRVWSLDSHGMARIWDSQNQQFIKEVEVVDQSKGGGGAVYQMISTTVNNTVWTATSQKLAIWDIDGGLIGEIPGESYSLCESQNKEIWVGGPQVLNIYSLDGIPSIAPSNCTSDDNNSNGAGGGELLKPIGTNLFMKGIIILAMCKVGQNRIWGCSSEKTLYVWDTKTKETIHQCEIQEKRPKRMACIEIDDTEYIWIGGDEGSIQIFNSKTFKLEHKILNQGWDKIFHIASINREIWIGFWDTTVRVFPGDPKNKEILIDYKGYHSDVVSSIIEVPNLKGGDPFVWFGSYDKSISIVSIKEDTAKSWNFTNIKKNFTRPIRQGFSSRG
The following text describes a protein:
Function:
Facilitates synapse formation.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Synapse.
Sequence:
MGCATTSVKIASIVLNAVLGFLAAGAIGWIAYNADTETEEFVIAAYIACSLILVFALLGIFAAIRESVVLTATSAVFLLILAILQIVSTCLFLHEFDVKSGRDMVEVAWQANNMDSLQQKHECCGQSSAQDYIHLSLLIPPSCYADLQQTPDHLYLDGCIEKVQSFYESDKLRFIIVSWVLVAFELICFALAVFLAISFKNKQRRMEF
The following text describes a protein:
Function:
Plays a major role in biotin-dependent carboxylase biotinylation. Catalyzes the addition of biotin to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase. Can also biotinylate methylcrotonyl-CoA carboxylase. Is responsible for most, if not all, biotin--protein ligase activity in Arabidopsis. Is essential for plant viability and required for ovule development.
Miscellaneous:
MISCELLANEOUS: The alternative splicing of the 5'UTR of HCS1 mRNA controls the dual targeting of HCS1 protein through alternative use of distinct initiation codons. A small ORF (uORF24) located in the HCS1 mRNA 5'UTR is essential for the AUG choice. The presence of uORF24 favors the synthesis of a short protein form initiated at the second AUG, which consequently localizes in the cytosol. In the absence of uORF24, the translation initiation begins at the first AUG, allowing the production of a HCS1 protein headed by a transit peptide.
Subcellular Localization:
[Isoform 1]: Plastid, chloroplast; [Isoform 2]: Cytoplasm, cytosol.
Sequence:
MEAVRSTTTLSNFHLLNILVLRSLKPLHRLSFSFSASAMESDASCSLVLCGKSSVETEVAKGLKNKNSLKLPDNTKVSLILESEAKNLVKDDDNSFNLSLFMNSIITHRFGRFLIWSPRLSSTHDVVSHNFSELPVGSVCVTDIQFKGRGRTKNVWESPKGCLMYSFTLEMEDGRVVPLIQYVVSLAVTEAVKDVCDKKGLPYIDVKIKWPNDLYVNGLKVGGILCTSTYRSKKFNVSVGVGLNVDNGQPTTCLNAVLKGMAPESNLLKREEILGAFFHKFEKFFDLFMDQGFKSLEELYYRTWLHSEQRVIVEDKVEDQVVQNVVTIQGLTSSGYLLAVGDDNQMYELHPDGNSFDFFKGLVRRKI
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MTHPNFQTNGASLEDCHTNFFALTELSGIKWRKLVYCELGGGGAASGHCSGGGGGGEPLEDPVLRSYARCLAADILCVWRRVSTPRSTDMFEPGPPPPPPLSLSTSKELWIFWYGEEPDLGVLIAPELNTPDSEQGSWESGLSYECRSLLFKALHNLIERCLLSRDFIRLGKWFVQPYEGPKKNDFTMTHLSFSLAFFVHGESSVCASVDVRQHPPVRRLTRLHLQQAQSSTSGLKVILAPYGLAGTLTGQSFKSSDQTSRLLEDWSHFYPLDKSSSLTDSSVVEVIVGGVKMKYPSCYVLVTDLDDNVNSAMNCTGVNPPNGLVKNGTSSPILTQTPPPSPIQINSRVPQPGPYSVSVEHLLSMSRDETAATVLPERAWQECIHGGPPGCTPQPTSNTPHEFTGQWDFVDPIKRANCTCSKCRKYVGSMTSNKWSTGATTKTTNSPRPSKAVRGRVPFHRRSPVPADSDRCSGSYTPQGGPPSYPRTQESVAIPSVGSPPSVAPSPLPNPHSQPASVPPGDQTMPMLSPHPPTLLPSPVEKTHTPDHPPKSVESTANSPSCPTDAKNEQVTNVTSVPVLKRPVLSVKEYESSLGDEEQTLEMLYDYSTLEAWLNHPVKRFKPDGKENKRNRLGKNDIYSMYNHNGVTVNNNDVTNNFNTKNQFIKQEIKQEMTESESTTPLGPMQGHGVKRPGDPYEFDEEGAGSACIDGFKRGQTVVKEEPKDSKKISTGNLFTSEGLQPSYKDLEQIFDNNSDDTSSDEAIQVQTPPGSTTLNHHEDNKRLSGHGGCPTMGCLRPEELSKMFPTPPSLEHNPIASPCGQMDLALPDYTDLGIVRTKQEIYPNMGSPPEEHIDDWTYVFKPPVLCKMVGSSKYAPLTNLPSQSLPVVTLPSYCVYKPSWIQHAEKPLQQLPPPSTTQPSIPNNLHQNSFPPSPLHGGFRQPPPPYELPSPATSTASSYLNKNLNSVEAVPTPSVQRTPEANSLALNILLTDTASNIFRDHNFDSCTLCVCNAGGRVVGNIRGADAGVYLISSSCDKTQSSVQQPSSPFPGACLGQPPPYGMLSPPHHHQQQLLVDEDGIRCSCGFSAVVNRRLAHGSGLFYEDEMEITGIAEDPGEKKKPSLLSFLIASNSIKLDPSIDRDQVDVLPHGLLELIREQCVVIPNTANALCRAAKYVCTKQTFNNIHVLEYSDSNEVTTIALEQSKSSYDLAVCKVEDKAKPAVGYAVHRWPFLRANGPQCNQDIVRVMRSLQPLLQEAIQKKCQTRLWEAPSAVKGPLTWRQFHRLAGRGTDDRCEPQPIPSVVVGHEKDWLSVSPYAIQHWESLLLEPYSFARDVAYIVVAPDNDAILPRVRTFFKELSTAYEMCKLGRHSPITKVLRDGILRVGKTAKAKLGNEPVEEWFTLLGEGEITDMLKLYAQVCKHHLAPHLQQVPMDKTLLDPPQESGDKPAPSPMPPPSTPDGGQAAEKAPSTPKSDQDGDGMKESTPQANTNAENSYDEDEREVPSVVVYLVEPFSLGSDQPELQRLACLALLRCFQSVLAAVPENIRNNISVQIISLESIVELGRARDRTRLSDHMRALSLNIFSQCRRLLVHTNNVKSLTGFGTAAMADLFLKSKDDKNRAAYKLYTPPYILAPMHEKIEAVESFGKGSGDQASVLYLSYCLSEDQSWLLAVATDERGEIFETVTINIDIPNRSRRKKASARRIGLEKLMNFILGVMSQSVRPWRLVVGRLGRIGHGELKGWSWLLSRKNLLNASKNLKEICNQCSLMYPTSVPCILSACLVSLEPDSVLRLMPDQFTPDERFSQVSVNSQLSTPQDVSCTHILVFPTSATTQSSQTTFQEQHITPELGDDELFSAFTAEDMPEGIDSMNDFSDIFNWTDTGPGGGQSPTGSPRREESGPGSPNCGVNNGRPGSPFHCGATNSKGNEQVEEVGTLLQQPLALGYYVSTAPTGRMPKWFWASCPHLEGICPAFLKNALHLHSPSIQQSSDDLFQQAAVTSHPLDSQYTTDVLRYVLEGYNALSWLALDSNTKDRLSCLPVHMQVLLQLYHTTAALL
The following text describes a protein:
Function:
PDR1 and PDR3 jointly control the transcription level of both SNQ2 and PDR5.
Miscellaneous:
MISCELLANEOUS: Present with 166 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MKVKKSTRSKVSTACVNCRKRKIKCTGKYPCTNCISYDCTCVFLKKHLPQKEDSSQSLPTTAVAPPSSHANVEASADVQHLDTAIKLDNQYYFKLMNDLIQTPVSPSATHAPDTSNNPTNDNNILFKDDSKYQNQLVTYQNILTNLYALPPCDDTQLLIDKTKSQLNNLINSWNPEINYPKLSSFSPRPQRSIETYLLTNKYRNKIHMTRFSFWTDQMVKSQSPDSFLATTPLVDEVFGLFSPIQAFSLRGIGYLIKKNIENTGSSMLIDTKETIYLILRLFDLCYEHLIQGCISISNPLENYLQKIKQTPTTTASASLPTSPAPLSNDLVISVIHQLPQPFIQSITGFTTTQLIENLHDSFSMFRIVTQMYAQHRKRFAEFLNQAFSLPHQEKSVLFSSFCSSEYLLSTLCYAYYNVTLYHMLDINTLDYLEILVSLLEIQNEIDERFGFEKMLEVAVTCSTKMGLSRWEYYVGIDENTAERRRKIWWKIYSLEKRFLTDLGDLSLINEHQMNCLLPKDFRDMGFINHKEFLTKIGTSSLSPSSPKLKNLSLSRLIEYGELAIAQIVGDFFSETLYNEKFTSLEVSVKPTIIRQKLLEKVFEDIESFRLKLAKIKLHTSRVFQVAHCKYPEYPKNDLIEAAKFVSYHKNTWFSILGAVNNLIARLSEDPEVITEQSMKYANEMFQEWREINQFLIQVDTDFIVWACLDFYELIFFVMASKFYVEDPHITLEDVINTLKVFKRITNIISFFNNNLDEKDYDCQTFREFSRSSSLVAISIRIIFLKYCYAEQIDRAEFIERLKEVEPGLSDLLREFFDTRSFIYRYMLKSVEKSGFHLIIRKMLESDYKFLYRDKLATGNIPDQGNSSQISQLYDSTAPSYNNASASAANSPLKLSSLLNSGEESYTQDASENVPCNLRHQDRSLQQTKRQHSAPSQISANENNIYNLGTLEEFVSSGDLTDLYHTLWNDNTSYPFL
The following text describes a protein:
Function:
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKGFLLLLSFMTRIPMPKTDYDEEKLGKSMKYFPVVGIIVGFILLFFCIIFNFILKNISYSAVLPLMIIVVILTDLITTGALHLDGLADTFDGIFSYRSKHKMLEIMKDSRLGSNGALALILYFLLKFILLFSLTIESREAAVYAIITYPVVSRFCSVVSCASSPYARGSGMGKTFVDNIKTCGLIVATVITLLYTIGMLFMPFILFTNYSLPMQFMIRSVLIIVIIVGLLALFAFAFSKLIERKIGGITGDTLGALLEISSLVYIFLFLVIPTFFIG
The following text describes a protein:
Function:
Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.
Sequence:
MPNCPNCQKPVYFAERVSSLGKDWHRPCLKCANKACGKTLSAGSHSEHEGKPYCNRCYGALFGPKGYGHGGTESHTFLQGTTGN