lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Displays aspartic proteolytic activity. Together with A39, contributes to pollen and ovule development, including the apical cell wall constitution of the growing pollen tubes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasm, cytosol. Note=Displays punctate cytosolic localization and colocalizes with the GPI-anchored protein COBL10 at the plasma membrane and in the cytosol. In pollen grains, mainly present at the plasma membrane and in reticular structures in the cytosol. In pollen tubes, exhibits a punctate localization in the cytosol and occurs weakly at the plasma membrane.
Sequence:
MVTTMDPSRISRIVAVVFVLVIQVVSGNFVFNVTHKFAGKEKQLSELKSHDSFRHARMLANIDLPLGGDSRADSIGLYFTKIKLGSPPKEYYVQVDTGSDILWVNCAPCPKCPVKTDLGIPLSLYDSKTSSTSKNVGCEDDFCSFIMQSETCGAKKPCSYHVVYGDGSTSDGDFIKDNITLEQVTGNLRTAPLAQEVVFGCGKNQSGQLGQTDSAVDGIMGFGQSNTSIISQLAAGGSTKRIFSHCLDNMNGGGIFAVGEVESPVVKTTPIVPNQVHYNVILKGMDVDGDPIDLPPSLASTNGDGGTIIDSGTTLAYLPQNLYNSLIEKITAKQQVKLHMVQETFACFSFTSNTDKAFPVVNLHFEDSLKLSVYPHDYLFSLREDMYCFGWQSGGMTTQDGADVILLGDLVLSNKLVVYDLENEVIGWADHNCSSSIKVKDGSGAAYQLGAENLISAASSVMNGTLVTLLSILIWVFHSFTS
The following text describes a protein:
Function:
Putative receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSTNLVDYVDDSYLNQSMNSENGLDSVTQIMYDMKKYNIVNDVLPPPNHEDLHVVIMAVSYLLLFLLGTCGNVAVLTTIYHVIRSSRATLDNTLIYVIVLSCVDFGVCLSLPITVIDQILGFWMFGKIPCKLHAVFENFGKILSALILTAMSFDRYAGVCHPQRKRLRSRNFAITILLVLAVYAFITLCPLLWSFTAREIILYAKETAPGMLTRMKIEKCTVDIDSQMFTAFTIYQFILCYCTPLVLIAFFYTKLLSKLREHTRTFKSSQIPFLHISLYTLAVACFYFLCWTPFWMATLFAVYLENSANSSSVPPVFVYIMYFIHALPFTNSAINWILYGALNGQLQQRYRSNRSNSTKKTTTTTASTALLEKKITNLNTNSNYQVNGSMNSIATAAPTKTIGNNEVLVATSTIDDDVATDVVDVRLLSNHNPTFL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MLQPLTIYRFEHITPFINTDYIYSSMAKAVDKSENSVSSTFECNICLDTVQDPVVTLCGHLYCWPCIYKWIQYQETSSETFENENAKCPVCKTEIAEKDIIPLYGPNLVTSNNGTDEKGPSDVGEIIPPRPPTPRHRGLGMLGRHGYRRLAPSPLALPGHDDTSTMDSAVVPSPTIGMLGEMVSGRILGELGSPLFGTPNSYNLVTVTRRERLRTTHADRSLSRIFSFFICCIMFCLLMFA
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MPALHIEDLPEKEKLKMEVEQLRKEVKLQRQQVSKCSEEIKNYIEERSREETVLDTNPFRSTLVISFTT
The following text describes a protein:
Function:
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKFVSDLLSVILFFATYTVTKNMIAATAVALVAGVVQAAFLYWKYKKLDTMQWVGLVLIVVFGGATIVLGDSRFIMWKPSVLFWLGALFLWGSHLAGKNGLKASIGREIQLPDAVWAKLTYMWVGFLIFMGIANWFVFTRFESQWVNYKMFGSTALMLVFFIIQGIYLSTCLKKED
The following text describes a protein:
Function:
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone (By similarity).
Subcellular Localization:
Melanosome membrane; Single-pass type I membrane protein.
Sequence:
MESTTVLLATSTLLLVLHASYGQFPRACSTAQVLLSKECCPVWPGDNSSCGEVSGRGVCQDVVPSNSPVGAQFPFSGIDDRENWPIVFYNRTCQCQGNFMGYNCGECRFGYTGPNCTVRRNMIRKDIFRMTTAEKDKLIAYLNLAKHTISPDYVIATGTYEQMNNGSNPMFADISAYDLFVWIHYYASRDAFLEDGSVWADIDFAHEAPGFLPWHRFYLLLWEREIQKVTGDDNFTIPFWDWRDAQQCELCTDEFFGGTHPTSNNLLSPASFFSSWQIICSRPEEYNSLRIICNGTNEGPLLRSPGRHDRNRTPRLPTSADVEACLSLTDYETGAMDRSANFSFRNTLEGFAVPTSGIANRSQSSMHNSLHVFLNGSMSSVQGSANDPIFVLHHAFVDSLFEQWLRRHQPSLDVYPEANAPVGHNREYNMVPFIPLFTNGEFFVQSRDLGYDYDYLAESGSIEDFLLPYLEQARQIWQWLLGAAVLGGLITAVIATIISLTCRRKRKTKISEETRPLLMEAEDYQATYQSNL
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Sequence:
MAFEFRLPDIGEGIHEGEIVKWFVKAGDTIEEDDVLAEVQNDKSVVEIPSPASGTVEEVMVEEGTVAVVGDVIVKIDAPDAEDMQFKGHDDDSSSKEEPAKEEAPAEQAPVATQTEEVDENRTVKAMPSVRKYAREKGVNIKAVSGSGKNGRITKEDVDAYLNGGAPTASNESAASATSEEVAETPAAPAAVTLEGDFPETTEKIPAMRRAIAKAMVNSKHTAPHVTLMDEIDVQALWDHRKKFKEIAAEQGTKLTFLPYVVKALVSALKKYPALNTSFNEEAGEIVHKHYWNIGIAADTDRGLLVPVVKHADRKSIFQISDEINELAVKARDGKLTADEMKGATCTISNIGSAGGQWFTPVINHPEVAILGIGRIAQKPIVKDGEIVAAPVLALSLSFDHRQIDGATGQNAMNHIKRLLNNPELLLMEG
The following text describes a protein:
Function:
Required during oogenesis to promote self-renewal of germline stem cells, probably by enhancing BMP signaling activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDEEEEEEVTDLKLQLFHNTVREHIIFLLLIILLYSSSYVVVSRFRRRDRDDLYSNDEDEVLVYRISFWLCTFTLAVAEGAAMLLPVSIASNEVLLLYPNSYYVKWLNSSLIQGLWNHVFLFSNLSLFIFLPFVYLFSESTGFVGNKKGILPRVYETFTVFMLMAIIVLVLTAVLSAVFGIEKLQFFWFLNLGSVHLPFLYSCVSFLGVMLMLICTPYGFVRLFGVVNQVLVRPMLLRDVNEEFSAFYMEEASVKRKLAHIELHNVSIADAANGGRLGNRIGLGRGRTFYPQPLLQHSQAHLYQRKAMASDVDELNDRLRELDSERKELDKLRTSSTFQRTFVYPLAMLLLLFCTAVTILLVVQNTLELLIGIKALPLSTRQFALGISSLSKLGPFGAGLEVCLIFYLGATSVVGFYSMPFMRKVCPKRRQTSLPQLMLNCGFMLVLSSALPLLSRIIGITNFDLLGDFGAIEWLGNFQIVLLYNLVFGTTTALCLANKFTATVRRELRARLVENYVLFTNYISFIN
The following text describes a protein:
Function:
Binds to CNTF. The alpha subunit provides the receptor specificity.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Domain:
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
Sequence:
MAASVPWACCAVLAAAAAAVYTQKHSPQEAPHVQYERLGTDVTLPCGTASWDAAVTWRVNGTDLAPDLLNGSQLILRSLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLSAPTYIPNTFNVTVLHGSKMMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNTTAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSNGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAPETTTSTTSSLAPPPTTKICDPGELSSGGGPSIPFLTSVPVTLVLAAAAATANNLLI
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MPFFDVQKRLGLNLDHWMTIQSAEQPHKIPSRCHAFEKEWIECAHGIGATRAEKECKIEFDDFVECLLRQKTMKRLSDIRRQRDKLIKEGKYTPPPHHLGKEDPRP
The following text describes a protein:
Function:
Involved in the synthesis of fatty acids. Elongates C18 polyunsaturated fatty acids (PUFAs) with a preference for Delta6 PUFAs.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVSLEQAEQIAAAIEVPDWVLTKSAALVYSCFGSAANAFESSIKINFPAQHAFVEAWMRARSHPFAERLPYLNPWHVIASILAYLSLIVTLRLLHRVLGKFSCRTLGLVHNLGLHLLSLYMSLGLMISARAAGYSLWNNAVGTSPAEWRIAKLIWLFYVSKVVEWVDTVIMLLKQNYHQVTFLHVYHHTTVFVLWWLALLVAPGGESYYSAMVNSGVHVFMYGYYFLTLLFPSGIVRDVLSKFKFAITKGQMWQFVFNCLQSAYDLVWVPREELKYSAELLQILFWYMISLLALFGNFLVKNKKFSHRRCVDAATASGAKEDTAARSHGDRTHRTRVKAGMTNMQLERLKNEKSTEMKLLMRKNGNGNGQKASLQAMAGSR
The following text describes a protein:
Function:
Involved in DNA repair and RecF pathway recombination.
Sequence:
MAIVLRTVDFSETSLIVTLLTKDLGRISALAKGARRLKGPFEGSLDLLSVCAITLIDKPGDTLDLLTESKLRRRFRGAQRSLERLHAGYYIAEMLRLLVDDDDPHRELFDMTLSAMGMIDGEGHVAKTLLAFDAQCLRLLGHSPATQRCTVCGRDAERSRRRASFSLVGGGVVCENCRPSQSHLMTASWDALDALRELASEPELPPSTIDADTDNPSQPPSTAFPIGRLFPAMTPAIYRDLRGLLNRTLESLVGQTPRMQPFLPDKLDSL
The following text describes a protein:
Function:
May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.
Subcellular Localization:
Golgi apparatus lumen.
Sequence:
MVSKQAFLFSLGSIYLSLLFIFLLMDVYARPANNSALKVETKEKAADNKDENEILPPDHLNGVKMEMDGHLNKEFHQEVFLGKEIEEFDEDSEPRRNRRKLAAIFSKVDRNEDKQISASEMQRWIMEKTEEHFQEAVNENKLHFRAVDPDGDGHVSWDEYKIKFLASKGFNEKEVAEKLKNNEDLKIDEETQEVLDNLKDRWFQADNPPADQLLNEEEFLSFLHPEHSRGMLKFMVKEIIRDLDQDGDKKLTLSEFISLPVGTVENQQAQDIDDDWVRERKKEYEEVIDADHDGIVTMEELEEYMDPMNEYNALNEAKQMIAVADENQDHHLSLEEILKYSEYFTGSKLMDYARNVHEEF
The following text describes a protein:
Function:
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus. Secreted.
Sequence:
MIRAGAGTWQRLRSPPQTGGSNSRMWQLASLLLLLIIWAVSSTPVPPDSVFSSSQRAHQMLRSKRANSFLEELRPSSLERECKEETCDFEEAREIFQNTENTMAFWSKYHDGDQCAVSPPEHLCDSPCCGRGTCIDGLGGFRCDCAQGWEGRFCLHEVRFSNCSTENGGCAHYCLEEEGGRRCRCAPGYRLGDDHLQCEPKVKFPCGRLGNRMEKKRKSLKRDTDQVDKKEDQIDPRLVNGKQSPWGESPWQVILLDSKKKLACGAVLIHVSWVLTAAHCLDDYKKLTVRLGEYDLRRREKWEVDLDIKEFLVHPNYTRSTSDNDIALLRLAEPATFSQTIVPICLPDSGLSERELTRVGQETVVTGWGYRSEAKTNRSFILNFIKVPVAPHNECVQAMHNKISENMLCAGILGDSRDACEGDSGGPMVASFRGTWFLVGLVSWGEGCGRLHNYGVYTKVSRYLDWIHGHIRMEEAFHKNQVP
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MLIDWFTVIAQVLNFLILVWLLKRFLYKPILNAIDEREKRVAAELADADAKEAEAQKEKEEFKQKNEEFDQQRAALLSRAKDEAKSERQRLLEEARKEASDLRAKQQEALRNDKQNLNRAISRRAQQEVFAIARKALQDLAGTDLEERTVDMFAKKLRELEGKEKEQLVSVLALASSPVLVRTAFDLPQAQRELIKKTIKETLGIEVQVCFETVPDLVSGIELTANGQKVAWSIAGYLSSLEEGIDELLQEQPRSEARTEPVLKQGETESKSEPKATARPESTSDVSEPEQKAEPEQESESEQESESEQESEPGQKAETKIVNPAPEPE
The following text describes a protein:
Function:
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAFVMVLTIVLDQLTKRIASEIHGTFFIVPGFLRFVKATNRGIALGLFKNLSEQLLWTVMFVVVFLSLLPYIFKFSRLERIAMGFILGGALGNLLDRIRFGYVLDFLNLTFLPTIFNLADVFIIVGGALMILGVFRGGDNESLESRKKRRGLETGSVFEGEDTIMDLEINDSKSDKRGQSEGQRSD
The following text describes a protein:
Function:
Mediates the conversion of 2-dehydro-3-deoxy-L-galactonate to pyruvate and L-glyceraldehyde in D-galacturonate catabolic process.
Sequence:
MAPPSLPCGIYAPTMTFFHPESEDIDIPTIKHHAQRLAKAGLAGLVVMGSNGEAVHCTRDEKIAVLSATREALDAAGFQSVPVLFGATEGSVRGTIELCKLAAAAGAAAALVLPPSYYRAQTDEASIEAYFVAVADASPIPLVLYNYPGAVSGIDMDSDLLIRLAQHKNIVGTKFTCGNTGKLTRVALATDAKTPFRDGSGYMAFGGMCDFTLQTLVSGGSGIIAGGANVMPKLCVKVWDSYSQGNRDEAEKLQKVLSRGDWPLTKAAIAGTKSAIQTYYGYGGYPRRPLKRLEQARVSAIEEGIREAMEIEKTL
The following text describes a protein:
Function:
Has a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MNLFNPAQLAKLGGATLPQAAPAIKFAQEQQGVLGRSLRPYFNITTSTFLKRLGLLMFPYVRFNERSTNLPLDLYMPLVGHAAYGVIMAFTEILSTGGFRPALFTRNVILAAIIVGLEALVVIGISSSVSLKVPKLELIALSCYKVFVSVIASFISIFNRVLYYIALVWLGVALGVHLALYGIGCIKATQSELYLSRRQISIQNWFVLLWAIMQPVLLFVLTIL
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Sequence:
MAWCFRDIRRHMCMLVRQNFAKSCEKKLNDQINMELKASHQYLAMAYHFDRSDISSPGMHRFFLKASVEEREHAEKIMTYMNKRGGLIILSSVPQPLPCFASTLDALKHAMKMELEVNKHLLDLHALAGKEADPNLCDFIEANFLQEQVDGQKILADYISQLEKAQNQVGEFLFDKYMGSGMHPAK
The following text describes a protein:
Function:
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space.
Sequence:
MGQKESSRLSPRGLHELRPHGQVLLSFSSGPSLPYSLLQGERNEPSGLVILQCVVADGNTTRTPETNGSLCGAPGENCTGTTPRQKSKTHFSRCPKQYKHYCIHGRCRFVMDEQTPSCICEKGYFGARCEQVDLFYLQQDRGQILVVCLIGVMVLFIILVIGVCTCCHPLRKHRKKKKEEKMETLSKDKTPISEDIQETNIA
The following text describes a protein:
Function:
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MEKKFKRTTVTSALPYANGPVHIGHLAGVYVPADIYVRYLRLKKEDVLFIGGSDEHGVPITIRAKKEGVTPQDVVDRYHYLIKKSFEEFGVSFDVYSRTTSKTHHELASDFFKTLYNKGEFIEKTSEQYYDEEAKTFLADRYITGECPHCHSEGAYGDQCEKCGTSLSPTDLINPKSAISGSKPVMKETKHWYLPLDKHEGWLRQWILEDHKEWRPNVYGQCKSWLDMGLQPRAVSRDLDWGIPVPVEGAEGKVLYVWFDAPIGYISNTKELLPDSWETWWKDPETRLLHFIGKDNIVFHCIVFPAMLKAEGSYILPDNVPSNEFLNLEGDKISTSRNWAVWLHEYLEDFPGKQDVLRYVLTANAPETKDNDFTWKDFQARNNNELVAVYGNFVNRAMVLTQKYFDSKVPACAELTDYDKETLKEFANVKAEVEKLLDVFKFRDAQKEAMNLARIGNKYLADTEPWKLAKTDMERVGTILNISLQLVANLAIAFEPFLPFSSEKLRKMLNMESFEWSELGRNDLLPVGHQLNKPELLFEKIEDSVIEAQVQKLLDTKKANEEANYKANPIRPNIEFDDFTKLDIRVGTILECQKVPKADKLLQFKIDDGLETRTIVSGIAKHYQPEELVGKQVCFIANLAPRKLKGIVSEGMILSAENNDGSLAVIMPQKEVKPGSEVK
The following text describes a protein:
Function:
Required for efficient splicing and pre-mRNA nuclear retention.
Miscellaneous:
MISCELLANEOUS: Present with 1470 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFHRRKRPYNTRNYGHDDKKFKSQYIDIMPDFSPSGLLELESNNKEGIALKHVEPQDAISPDNYMDMLGLEARDRTMYELVIYRKNDKDKGPWKRYDLNGRSCYLVGRELGHSLDTDLDDRTEIVVADIGIPEETSSKQHCVIQFRNVRGILKCYVMDLDSSNGTCLNNVVIPGARYIELRSGDVLTLSEFEEDNDYELIFMNV
The following text describes a protein:
Function:
Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Also induces the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
Subcellular Localization:
Nucleus.
Domain:
Contains 3 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.
Sequence:
MAGNDCGALLDEELSSFFLNYLSDTQGGESGEEQLCADLPELDLSQLDASDFDSATCFGELQWCPETSETEPSQYSPDDSEFFQIDSENEALLAALTKTLDDIPEDDVGLAAFPGLDEGDTPSCTPASPAPLSVPPSPALERLLSPVSEVDELSLLQKLLLATSSPTASSDALKDGATWSQTSLSSRSQRPCVKVDGTQDKKTPMLRSQSRPCTELHKHLTSVLPCPRGKACSPPPHPSPQLLSKEDEEVGEDCPSPWPAPASPQDSLGQDTANPNSAQVPKDDVRAMVQLIRYMHTYCLPQRKLPQRASEPIPQSCSSPLRKVPPRSRQTPKAFWTEFSILRELLAQDILCDVSKPYRLATPVYASLTPQSRTRPPKDSQASPAHSAMAEEVRITASPKSTGPRPSLRPLRLEVKRDVNKPARQKREEDEEEEEEEEEEEEKEDEEEEWGRKRPGRGLPWTKLGRKMDSSVCPVRRSRRLNPELGPWLTFTDEPLGALPSMCLATETHDLEEELGGLTDSSQGQQLPLGSQIPTLESPCESGCGDTDEDPSCPRPPSRDSPRCLMLALSQSDPLGKKSFEESLTVELCGTAGLTPPTTPPYKPMEEDPFKQDTKHSPGQDTAPSLPSPETLQLTATPGASHKLPKRHPERSELLSHLQHATTQPVSQAGQKRPFSCSFGDHDYCQVIRPEAALQRKVLRSWEPIKVHLEDLAHQGATLPVETKTPRREADQNCDPTPKDSMQLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLLEEEEEEGGEEDDEGEDSGVSPPCSDHCPYQSPPSKASRQLCSRSRSSSGSSSCSSWSPATRKNFRLESRGPCSDGTPSARHAKKRREKAIGEGRVVYIRNLSGDMSSRELKKRFEVFGEIVECQVLRRSKRGQKHGFITFRCSEHAALSVRNGATLRKRNEPSFHLSYGGLRHFRWPRYTDYDPTSEESLPSSGKSKYEAMDFDSLLKEAQQSLH
The following text describes a protein:
Function:
Involved in the transposition of the insertion sequence IS150.
Sequence:
MKVLNELRQFYPLDELLRAAEIPRSTFYYHLKALSKPDKYADVKKRISEIYHENRGRYGYRRVTLSLHREGKQINHKAVQRLMGTLSLKAAIKVKRYRSYRGEVGQTAPNVLQRDFKATRPNEKWVTDVTEFAVNGRKLYLSPVIDLFNNEVISYSLSERPVMNMVENMLDQAFKKLNPHEHPVLHSDQGWQYRMRRYQNILKEHGIKQSMSRKGNCLDNAVVECFFGTLKSECFYLDEFSNISELKDAVTEYIEYYNSRRISLKLKGLTPIEYRNQTYMPRV
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion membrane.
Sequence:
MKMSLKKLVSLCAAAAPGLTAGMSEAKKRSSQPLLDLNELPSLYTVPESKPLEAEREAGPLEQTVALLRKWAEPYTNHCQQSVQTGVEKAEQAYGTVEPYIHAAVRTATDTYRFLSEPPPDLYPGVAVVGFSGFLGLYLAKGSRLKRLLFPVGLMALSASMFHPQQAAALLKTGRDSALTWAEQGRVTVETLWKDPPFSKKKLKSSEKTEKENDRSG
The following text describes a protein:
Function:
Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MKAGIPLSRCTQRIPLLVARQVSRNITTTTTKFSLAPEYNHIRKVFDSQKYFNHFTKQGSHATLFSSPQTGLFHNEYLTTPQGLVDFSQQSLSQAKQLVSEMLSQVNTVDGKLKFIKKLDQLSDILCRVIDVAEFIRVVHPSVKWINAAQQTHEMMFEFMNQLNTNVELYSSLRDILNNPLITEQLTPEEIKVGEYLRQDFERSGIHMDPQTRENFVTITQEISLLGSQFGNQINGLKSYWCPVTVAEWESIEDPQLKKEIKNYQSKYDGIRQSETIQIPLVANIPYTILTNCSSDTLRKKVWVALHNSPDEQIETLNRFISYRALLSKMLNYKSFADYQLEHKMAKTPENVITFLFNLQKSLIKKGVVEELSQLSEIKHNGSGSASVNDIVNDIKPWDRDYLLARLQQRMQSEVSAGNVKEYFSVGTVIAGLNELFTRLYDISFVPMAALKGETWDSHQVRKIKVVDNAANKTLGFLYLDFWSTKVLPSHFTIVCSRRLNTSIGSETIEGMEKLVQLDEDYQLPVVSLVCNFASSGNFSFGRFAGVENEKPTLLTLDQVDTIFHEMGHAMHSMIGRTELHNLSGTRCSTDFVELPSVLMESFSKDPRVICQIGRHFDTDEKLPESLLGQAHEHRIMLDACETFMQSKMAMLDQKLHNEEMVNLLAKGLYEVDSTKVYHSVEKELKVFADEWSTWHGKFPHLFSYGAVYYSYLLDRAIADKIWQGLFAKDPWNGEAGKKYKESVLKWGGTRDPWECLADALGNDELKQGDSRAMEIIGQNSNL
The following text describes a protein:
Function:
[Vasoactive intestinal peptide]: VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles. Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
Subcellular Localization:
Secreted.
Sequence:
HSDAIFTDNYSRFRKQMAVKKYLNSVLT
The following text describes a protein:
Function:
Polycomb group (PcG) protein that binds to the 5'-CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MAYERFGIILQSEQYDEDIGNTKVNQKMNEGNHYDLHRKNAFDRIIHSESKKGDNVINYNIHENDKIKAADNIFSSKLKMNPNMSYEMNINCFKNIGYGENQETSKVLTNSLSNNDINTEESGVVDKNSPFLTLGTTILNSNGKSRRWEQKLVHIKTMEGEFSVTMWASGISDDEYSGSDQIVGASDLLKGKEEFGIDGFTSQQNKEYQKMESKFTNAQTLEMPHPISSVQIMDHLIKERGNLSQENNISERILSKTTLSFEEPILLPDSSSIELVNETAAMTINNHRTLSNHTGNTGDLHALPSSVPFRIGLHEGQVNDCLSTISQSTHQDNTDSTGCGEMNLSEVTVSYTNDKKIACPHKGCNKHFRDSSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNLKSHILTHAKAKRNTSISGKSGCSNAESNSQSEDTSANYVKVELQDSVTENHVPFVVYAD
The following text describes a protein:
Function:
Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells. The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MGGPTTRARRAGKMGRSAWIFGEPSSIPGCWLYPWCPAQHLVHSGYSVKMQRLKRLAMEEEGSGCNVPRLPWASILRAALLLLLIGMVIYCFLCGQRFTQQQLDSTGWDLAELLLNHTESRQDPRLRWQGSPALGRSFVHGPELDNGQLRIQRTGIYRLHIQVTLTNCSSSTWTVMPRQATLTLGICSPTTHSISLLRLNFHHTCRVASQRLTPLAKGDVLCTNLTLPLLPSRNADETFFGVQLVRP
The following text describes a protein:
Function:
Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction (By similarity).
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein.
Sequence:
MELHSLSKRNSPVDPCNALEWSSGETSGDHIEEATIRDAFCYQKNLVSTPRADVVEVCRLSTSPASPTSLLQDSAIQTSFSLSGPPDSGNNQVMADRKVCNCCSQELETSFTYVDENVNLEQRSQRSPSAKGSNHPVDLGWGNPNEWSHETAMSLMSEDDDDTSSEATSSGKSVDYGFISAILFLVTGILLVIISYIVPREVTVDPNTVAAREMERLEKESAMLGAHLDRCVIAGLCLLTLGGVVLSCLLMMSMWKGELYRRNRFASSKESAKLYGSFNFRMKTSTNEDTLELSLVEEDALAVQS
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MDPTCVMCNQCFQNSIHKDHRYRMHTSAGGAGCCDCGDAEAWKSGYACDFHLANDVEAAPVQLPLDVERRCSIVFDAVLRYAITVLLYDGPDDMPAELFQMSLPPLYVTTLYNDEVHTYQEVIRQLQLAISCTELQASQIAGIVDRTGRARIGVGDAIECNRIRRIIQKRNSELPHIPIRGAKPLVIKILHTTLFEHQELAINLLNWLNDFTSSSSALILLFGKIAMDSNSHFDKSYLEILLHSDTQLWKGSSDLKHQFSVLYVKEYAKIQKDFIEDDHLHSVSITSMSVQLFTSNSLSRYLVIEHDCLAKILSTFCNAIKPSINPVAARDGRLAQLRIHELSRLEYMIIDVKYILSQVPDAESWTDDLKHAFLRGFDEYLKLLSILEGMESSKRVSGRHIEYEPNWEFSVRIYITLCIIAPLILQWCTSNREEILPILLMEHSVRALVLAAQVASSMWKFNGYYIVNQVHHYKVGKCRSQAYDKDILMLQIVGSIVDPDWFLACLLQKFKLLDWVDIQGGSRIDNLKEDIWVARSSLAREFLLLLIAVIGERYHVGIGDVTPADTVRHEILHYLYVSPKAHSEITKFLSTSQEDCAEVDIDEVLSTIANYRKPGLTGRGVYELKPEYYEEYNPFFYHYSVSDHSKAEERRKRIKTESDNRNQSPPSLPKLTKPFYSLNRILQSSLLRRMLLTILTRCCEDSQKNWIDPLLHPTLFLIAMNFGEIESAYREGFINLNSELSLLSEIISKIDILKNETSASDFSKLINWIISTYRKLVSFTAGSNSVTNVTSETTGKNRFEEAKRARARLAAQQRNKIMAQMSAMQKNFLTRNADILSTLQTDSLTDPESSETLMEMNETDEVIAVGASRSCFHIGAPETISCILCQEDEQIKLSDRPMVLTGLSHRSVVLSQLGSENDTKLEFKPLWTDTAIAIGVHTGSCAHAMHSSCWQNYFVATVDRQQIRRFNARAPPSINVTKGEYLCPLCEGLCNCAIPILPPLPYFINNDNMKEYPKWLEDLRVHTINELQNIRGHTGSNAAMIDSSISLFTPLDLLNRKSSPELNQLRYELPEAAIEAIKAFSQSVYTSGLLAKPCADNERILYALWSSCAYCIGVAVNFLSFRSKSVEEGLTTRQVNLIFSLQALSDSPGIVAFGTDPVMHHYCLKIAFMLKITQSLLAITDIDVSSENDESSDDDSSFLVQYWQFLQMHTGKGAISFPYSASITLCRKVKEVCLPFLRMASLFFHLITSVPVPKFDLDAAQEYSHLLKYLDLPAKLSTLLDLSNSEISGLVIRELSPCSTLINLPRNYGELICGTANYRCSNSKASLNSSPAMCLICGKLVCAQNYCCQGTLGDDKVGSITSHIYECGAGVGILLFVRECRIILRFGQRRGCFYSPPYLDEHGETDEGLRQIVKVPIVFLYTACNSTQAMIMEIIELLFHKDPVG