lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2. The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR.
Subcellular Localization:
Cytoplasm.
Sequence:
MLGVKWCRSKDAEESPGFSTSLPPHPHPSRGVRSGLTKPHTFFFAGKLWVTALAGDLAIRALGPGEEEPEAPQPPRLQHFGSPAGTRFGDPSDSQAGRVSPPTPARAATCLCRGDPAPMTLRCLEPSGNGAEGTPSQWGPAGPAEEPTPEAARLAKALRELSHTGWYWGNMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPPLQHLCRLTINKCTGTIWGLPLPTRLKDYLEEYKFQV
The following text describes a protein:
Function:
Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.
Subcellular Localization:
Nucleus.
Sequence:
MEEVGTQLAPPLYMYNTIGAGRFPDAHPMAKKRSLPYQNPNLIQHQQQQQYLQRLIPTLNEPRNSWNPKNWEWDSSRLVAKPLDMMEISREQQQQQHHHQTAVNPPNPDGSKKSPVGQREEDERLLLKLGGGEEAATRPSKRVRSGSPGSGCAGNYPMCQVDNCKEDLSTAKDYHRRHKVCEVHSKAGKALVGKQMQRFCQQCSRFHPLSEFDEGKRSCRRRLAGHNRRRRKTQPEDVALQLLIPGNGDKNGANDMDIVGLLTVLARAQGNAEDMSRNSSPLPNKDQLMQILNKINSLPLPVDPGSKQPVPGSLTNVDQEKTSSEVQKVNKKTSSSTMDFLGVLSGSSDAPEPLSQKRNQVIEADKNKTNSGCVNQTMVHSGGERSSTSFQSREDSDCQVMDTPLNLQLQLFSSSPEDDSPPKLASSRKYFSSDSSNPMEDRSPSSSPPVVQRLFPTKASRERMKPESMSTSGEVTANVKATMSLELFGGMNNGADNVSIQSSPYRAGYTSSSGSDQSPSSLNSDPQDRTGRLSFKLFDKDPSHLPGSLRTQVYNWLSQSPSEMEGYIKPGCVVLSIYLSMSSSSWDQLEGNFLQYINALVQESGTDFWGSGRFLAHTEKQIASHKDGKVHLFKSLKAWSSPQLISISPLAVVSGKETSFVLRGRNLRTPGTKIYCTHADGCILEEATESTDQDSTYEEISTRRFTICAPSERGRCFIEIENGFRGTSFPIIIADSTLCQELNLLEAEFGEVQNRQPSLVKETIHFLNELGWLFQKKNGGSGSHYSLTRFKFLLVFSVERDLCGLVKTLLGILLQKGSGGITEDDSSMEMLYTINLLNRAVKRKCKNMVDLLIHYSVVGDTDTDSAASRKYIFPPNLAGPGGITPLHLAACTSDSDDMVDALTNDPNEVGLLSWNSSLDANGLSPFVYATMRNNNSYNTLVAQKLANRIAGQVSVHISNEIELQTARRVDHVDHHELSFRVRDHHVGTKSCSKCAIVTAKHPRRIPGSQGLLHRPYIHSMLAIAAVCVCVCLFLRGAPNIGLVAPFKWENLNFGSM
The following text describes a protein:
Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.
Sequence:
MAETKSTSRAGSKLNLNESTMPLLDDEAHEKAETPEKDVIEMKEKASTTSEGEKDDSNPEKIEEEKKDGDEEGGDKKKKKKEKKEKKEKKEKKEKTASCHRRTQSCVQTFTVGLNVLDRDEKHINDTINLNFEDVLAEPDVAHGFDPIWRAAFILFTGSRFWIYRLLSAILALPLALVWGITFSLITFFSVWLATPLLRIMDVFLFYIRRVWVALVQTTLEPVANAVGGCFSNVKLTHNNQLQTV
The following text describes a protein:
Function:
Probable nucleotide-diphospho-sugar transferase required for pollen germination and tube growth.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MTISNGDVKSETCNNGSSEKKPFRIFVGYDPREDLAYQVCHHSITKRSSIPVEITPIIQSDLRKKGLYWRERGQLESTEFSFSRFLTPHLSDYQGWAMFVDCDFLYLADIKELTDLIDDKYAIMCVQHDYTPKETTKMDGAVQTVYPRKNWSSMVLYNCGHPKNKTLSPEIVNTQTGAFLHRFQWLEDEEIGSIPFVWNFLEGHNRVVEKDPTTQPKAVHYTRGGPWFDAWKDCEFADLWLNEMEEYNKENKKEADNAK
The following text describes a protein:
Function:
Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore.
Subcellular Localization:
Secreted. Target cell membrane; Multi-pass membrane protein.
Sequence:
MMRIEVALQLGFCSLCLLLGFFRGGAAVEIPDPPPINCVWSRWSEWTTCDPCTKIRRRSRAIEVFGQFRGDACQGSIGESTACTTSEACVNPTAIPCSDIEFECESRKCIKKRLMCNGDYDCEDGSDEDCDPVRKPCGQTVLINNEQGRTAGYGINILGANPRMNPFNNDYFNGRCDRVRNPNKGNYDRLPWNVGVLNYETLVEETVSREIYENTHSLLKTMIQDKTFKLDAGFNVKLSPSEPSMSNLSGTIGADLGFSRQNMLKEVTEYTTIKNKSFMRVKGRVQMSTYRMRSRELQLADEFLKHVQSLPVEYEKGIYFAFLEDYGTHYTKNGKSGGEYDLVYVLNQDTIKTKQITERTLQQCIKAGITADFGVPGVDVSGHVKPEGCDNPKEITQADTDGKAVVDKVVTSVRGGNMESAVAMRGKLNKEGIMDIGTYQFWARSIADAPALLSSEPEPIYMLVPPNMPDSNARIENLKRATQDYMAEYNVCKCKPCQNGGTLALLEGKCICICPDVFEGSACQNFKPDKNKGPATRPTVDQLGNWSCWSTWSSCSGGKRSRTRFCKTDGVPGASCTGDTNSDEYC
The following text describes a protein:
Function:
Acts as a zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMTFLCTRSGRRASGVECRIAAERAYFRVRGLPVANMIGWWPRLCPVMSLALLWACSVGAGSDCKSVAIETDSRIAEQTQQRHLQALFDKYGQNGSISLEGLFNLLKGVGLDRIRKVMVHHPGNAHNHTHTHDHTHTHVDKLTAHTHPVTTKKGDMDHSVEKSDPVPKAQPDPASGKKSQSDAHHNLYMKMNQESTTALTTPSYVTRSRRTNRSADYDFTQDHASFSPSQPNVTHSNHTHHDEDTPTHQHDDHDEHEHARASLGCQNASTILQTHGMRKEASLSVKDFSFLCPALLMQIDSKSCIVHEDEDEHSDHSHHHKHHHHHHDHQHLQHPHNHTNGRGQRNTPVYIAWLGGFLSITLISLLALVGVVLIPLMNRVCFNFLLSFLVALAVGTLSGDALLHLIPHSQGHHHHGHSEEHAEEEDSLRPVWTGLTALSGVYIMFLIEHFLTLGKMYKDKNQKVQKRVDLTTEVLESEKLPSLEENDVKIEAAETNGGRALAEEEEVMLGAELYNDIDCENKCHSHFHDTVGQSDEQHHHHHDYHHILHHHHSQNHHPHTHTHRHTHSYSQQHFEQAGVATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSSGLSTSVAVFCHELPHELGDFAVLLKAGMSVRQAMLYNLLSALMGYLGMIIGILIGHYAENVATWIFALTAGLFMYVALVDMVPEMLHNDASEAGFSHYGFFLLQNAGILLGFGIMLIIAVFEDRIQLDLGY
The following text describes a protein:
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase.
Sequence:
MGAAAGAGGDKMGNKAKRGRGQQKGRGKKKTGGRPVTQVATAPLVKRVVEKGLVGRRSGRKHAAAIAYMHQLNKDLAHAQANQETHRAAAIEQELTELGGIEAYQQFSLKSESRGVTNSSRWVVSMLREAQLHSPAGRQEAFGAPLPQLALLDVGALDDNYRRERAWIATRAIDLNSQHPFVEKCDFFTVPDEPRYHVISLCLVINFVPSPAQRGAMLRRCHELLHPDGWLALMLPLACVNNSRYTTEDRLLQILGAVGFAVRQRKHTKRLACYWCQRVEPQTPVARELQTKAVLVEGGGRNNFAITL
The following text describes a protein:
Function:
Required for maximal expression of sirC, not required to invade host cells.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTIAMLLTLHLICVALSVSLFVARYWWRYCGHALAAARWTRIVPPVIDTLLLLSGIGLIVKTHILPFTESGSWLTEKLFGVIIYIVLGFIALDYRQARSQQARFIAFPLALVVLYIIIKLATTKIPLLG
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Localized at the central region, but not at the outer repeats, of the centromere and remains at the centromere during mitosis and meiosis.
Sequence:
MNMEEQILNDYLLSQGRLQSIISLEQWRQLFPQRYREDPLIERLYEYCTQQRQKRLAKLRANIHLESQVIGKSRIDRMLATNVEKLQTVSHASTLHDVEEFYTSHSAKPLDISEINERLSEAVQSAYTKLNEEKERCTQLTLKMNSQIASLSDFQWSKEPNVDESIHLVESLIESLEKAAPSAIEELD
The following text describes a protein:
Function:
May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein.
Sequence:
MGRWALDVAFLWKAVLTLGLVLLYYCFSIGITFYNKWLTKSFHFPLFMTMLHLAVIFLFSALSRALVQCSSHRARVVLSWADYLRRVAPTALATALDVGLSNWSFLYVTVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQFNVEGFALVLGASFIGGIRWTLTQMLLQKAELGLQNPIDTMFHLQPLMFLGLFPLFAVFEGLHLSTSEKIFRFQDTGLLLRVLGSLFLGGILAFGLGFSEFLLVSRTSSLTLSIAGIFKEVCTLLLAAHLLGDQISLLNWLGFALCLSGISLHVALKALHSRGDGGPKALKGLGSSPDLELLLRSSQREEGDNEEEEYFVAQGQQ
The following text describes a protein:
Function:
Involved in the dephosphorylation and activation of the transcription factor GLN3 in response to nutrient availability. Forms the histone H2A phosphatase complex in association with the regulatory subunits PSY2 and PSY4, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAGMQLDEIIEYLRYSKHIPEETIYELCLKCQELLVNESNVTHVDTPVTICGDIHGQLHDLLTLFEKSEGIEKNRFIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVIRKYGNSNVWRYCCEVFDYLSLGAIINGQIFCVHGGLSPDVMTVDEIRSIDRKQEVPHEGAMCDLLWSDPDEVDTWSLSPRGAGFLFGKNEVDQFLHRNDISLIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLRIDDDLSRNYTIFEAVPAQDNRGNAIIPTKKPQMDYFL
The following text describes a protein:
Function:
As a component of the decapping complex, involved in the degradation of mRNAs. Promotes P-body formation. Translational repressor (By similarity).
Subcellular Localization:
Cytoplasm, P-body.
Sequence:
MASESSQSSSPSSSQPPSSVPSPSPGNNVGDTFIGSFISLISKYEIRYEGILYHLNVQDSTLGLKNVRSCGTEGRKKDGPQIPPCDKVYDYILFRGSDIKDLQVNPSPSAQSRQEIQSEQDVNQSPHSRPAMTMSSPISGYDSGYGLGRGSQWINTPALSSKPVPVTQHSSVPLSFQPPSANAGSLTESPVSLIDSTQSNAGSSMPIPSFVQGNKFASSGVPLGMMQKPVSSSSTIPNGPQIIDYFSSPIMGLVDDSSQVVTRSPDVSSNQSYSSNPSPLGQTQLHTPPGLASVSSNLSPPSEAQLSAPNIQKIYPSAPQAIGKVVYDPQSNHPHRSIPHELPAVASNSAPVIPGPLSKSPESFFDMDPSLQSRQQMVYRGQEMFAATNPASANVPSQSFAPRNHAPLLPLPVSAHQSRIPSSSIEYTEEFDFEAMNEKFKKSELWGYLGRNNQRNQNDYGEETAIEPNAEGKPAYNKDDFFDTISCNQLDRVARSGQQHNQFPEHMRQVPEAFGNNFQRPPPLQPGQGAYLAAQTNYRGGYHNNNNNNYYSNSGYGYYSGGRGRGRNTHF
The following text describes a protein:
Function:
G-protein coupled receptor that binds to several ligands including resolvin D1 (RvD1) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. In macrophages, enhances the RvD1-stimulated phagocytic and clearance functions. Macrophages migrate less toward different chemoattractant stimuli but phagocytose more microbial particles. Prevents the increase in Ca(2+) and activation of ERK1/2 used by histamine and its H1 receptor subtype to induce goblet cell secretion by activating PKC and GRK2 to counter-regulate the histamine receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNGVSEGTRGCSDRQPGVLTRDRSCSRKMNSSGCLSEEVGSLRPLTVVILSASIVVGVLGNGLVLWMTVFRMARTVSTVCFFHLALADFMLSLSLPIAMYYIVSRQWLLGEWACKLYITFVFLSYFASNCLLVFISVDRCISVLYPVWALNHRTVQRASWLAFGVWLLAAALCSAHLKFRTTRKWNGCTHCYLAFNSDNETAQIWIEGVVEGHIIGTIGHFLLGFLGPLAIIGTCAHLIRAKLLREGWVHANRPKRLLLVLVSAFFIFWSPFNVVLLVHLWRRVMLKEIYHPRMLLILQASFALGCVNSSLNPFLYVFVGRDFQEKFFQSLTSALARAFGEEEFLSSCPRGNAPRE
The following text describes a protein:
Function:
Involved in cell wall degradation. Degrades polysaccharides containing beta-(1-->4)-linked galactans, acting as an exo-(1-->4)-beta-D-galactanase (By similarity).
Miscellaneous:
MISCELLANEOUS: There are three forms of the large subunit which have the same sequence but differ in charge. There are four forms of the small subunit which have the same sequence but differ in charge.
Sequence:
TGVTYDHRALVIDGXXXVLVSGSIHYPRAASSWYAVET
The following text describes a protein:
Function:
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
Sequence:
MLYGTKFRFPVKVDDKIFPTNDPNITVVSFIGKTNLVNQFPTKITCINDYFKHPIFQNSEISEESSIEGYFCSKKKVLFLYCNNIYDTNTLLMLDKLEFDNLFEKGFLHYFSNLRDTSTRHLIFLFLVSHICVVTNASSNFDLNYIQLFKTLDSVRIKLQSSVAEVLKTVPGLPKDWLTLGRLCSPRVLFYFEQRPPVLDDNLKSLQHLMEDQIYRLLRKCRVITNVCTNSLFAIPSNQEFVFFKPKQQDRFTFLLDLLNDTFEIGDSENSNDFREFLNQHIVLAQTEGFSDNVGRHIGPSIFVGFQLLRSILDVEGQFSEARCLKVLPLALAAYQENLPSHYSSQYHENKKTQAKALLSSHGRGPAVQKFLGRLDVECDRFWRNGRRMCEFPSIIGNPCIQPVHRVLGEENGENKLSVLPHMSGVRYVSACSCGRRQANREDPYDVKYANYDFYRLIEEECCGRLRHITFPIFKPSSEHFEAAKLKGSSKSMHFAKDVEKLITGTEDLSLGPDENEFPALSVDHLSQVAADDHEDSQTSLGKGEAAEAIDEENMIEITGTHEQPTISTRDFSTTEYLPCMLHVHSPVGILPRYSSWSLVCLGSSSLYSHNAGLSDQPGFLTGSGFLLPWDIPVRLQHNESNSLEGRRTHNIGYSGKGKRAKQGQHEFTVKVFIGVEYECPRGHRFMSSSPGRVLKATGAGLVKDSAQLITQNDVPLYLPCPCPYNRGGKALIAQLMRLHVVTPKAAVHVTIDPKVRPAPPPCPEFITGFSEPVQLSPSSYWILRFPYVYEDENQIYTLPKESSRAAQHGYLLKGTCGVVELANE
The following text describes a protein:
Function:
May be involved in the regulation of the inflammatory network. The role as pro- or anti-inflammatory seems to be context dependent (By similarity). Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 hours post-injection (Probable).
Subcellular Localization:
Secreted.
Sequence:
MLLLLLGFLGPAACWALGPAGPGSSELRSAFSAARTTPLEGTSEMAVTFDKVYVNIGGDFDAATGRFRCRVPGAYFFSFTAGKAPHKSLSVMLVRNRDEVQALAFDEQRRPGARRAASQSAMLQLDYGDTVWLRLHGAPQYALGAPGATFSGYLVYADADADAPARGPAAPEPRSAFSAARTRSLVGSDAAPGPRHRPLAFDTELVNIGGDFDAAAGVFRCRLPGAYFFSFTLGKLPRKTLSVKLMKNRDEVQAMIYDDGASRRREMQSQSVMLPLRRGDAVWLLSHDHDGYGAYSNHGKYITFSGFLVYPDLAAAGPPALKPPEL
The following text describes a protein:
Function:
Lignin degradation and detoxification of lignin-derived products.
Sequence:
MFFRVSIIGFLQALTVFSAATASSLVQRDSSCNTPDNRACWTDGFDITTDWEKEVPYTGRTVHYTLVLEQGDIIGPDGVFKHDAMLFNGSFPGPTITADWGDYVNVTIINKLLYNGTSIHWHGLQMEDNNINDGVGGVTECPIPPNATKSYLFLAEQYGTTWYHSHYSAQYGNGVLGAIVFNGPASANYDVDLGTFPINDWYYESADQILAQVQAPGEHGGPTIPPPPDNILFNGTNVNPADITMGEYARVVLTPGLKYRLRLFNPSVNYAYTFSIVGHNFTVIATDLVPVNTTDPSTTVSSLFIAVGQRFDIIIQGKTEEEIASDGGNGNYWINATQPISGYCGNFYGKPAAILSYDFPDATDELPIVDGLVPEDLRCEDSTDFRPVVVRDVPPSEFSISEYNTLPVHLMNDKKQSKVFWTIDNVAINVSWEQPLLEYIREDITFWPYSENVLEIPPESEWSFWLIENKSKIPHPMHLHGHDFVIVGRSPAPDGPGLSDAMMPVRHFDPVLDTSSLNFTNPARRDVTMLPGNGWLIVAFQNENPGAWLFHCHIAWHVSMGLSVQFLERKNEIKEKMDLNLLVDNCAAWQSYIDTNPPYQPKNDSGV
The following text describes a protein:
Function:
DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Binds in the minor groove of AT-rich DNA. Represses expression of multiple genes involved in a broad range of cellular processes, including major virulence factors or antibiotic-induced genes, such as iniBAC or efpA , and genes important for adaptation of changing O(2) levels. May also activate expression of some gene. May coordinate global gene regulation and virulence. Also protects mycobacteria against reactive oxygen intermediates during macrophage infection by acting as a physical barrier to DNA degradation; the physical protection has been questioned. A strain overexpressing this protein consumes O(2) more slowly than wild-type.
Subcellular Localization:
Cytoplasm, nucleoid.
Domain:
The C-terminal domain binds DNA and the N-terminal domain is involved in dimerization. Both domains are essential for normal function.
Sequence:
MAKKVTVTLVDDFDGSGAADETVEFGLDGVTYEIDLSTKNATKLRGDLKQWVAAGRRVGGRRRGRSGSGRGRGAIDREQSAAIREWARRNGHNVSTRGRIPADVIDAYHAAT
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTTSSAKKPLHSLVFCKECGSLLDPPNDIEDYVVCHCCATVVDAKEFELRPVVTVSKQATFPDKPKPIVDPSDDNNDRTNAHLRDGATIQEKCPKCDAPEMVFHTAQLRSADEGQTVFYSCVVCGYKYSINS
The following text describes a protein:
Function:
May play a role in the control of plant organ development and specifically in the regulation of stamen development. Does not show transactivation activity in yeast.
Subcellular Localization:
Nucleus. Note=Detected at discrete loci in the nucleus.
Sequence:
MATAVGGGSDVEVGFAKLQGEDFEYYMQSYSIILGRNSKKATVDVDLSSLGGGMNISRNHARIFYDFTRRRFSLEVLGKNGCLVEGVLHLPGNPNVKLDSQDLLQIGDKEFYFLLPVRSILGGPLGPRHHVSGQTSVVPYHNYQSGPGSGSGKKGVRSRELYEYDDEDDDDDDDEEDDMRGSGKKTRRDGHEVVYASGEKKREGRSKVDREADDQQFLQLEEKDVVSSVATVLSDLCGPGEWMPMEKLHSVILKEYGNVWHHSRVRRYLSQEDWAIPEAKGKPWYGLLMLLRKYPEHFVINTRSKGRVTLEFVSLVTLLS
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B.
Subcellular Localization:
Nucleus.
Sequence:
MSMDHQDLKRRDPPADSESQRPSKKISLSSSEASVPIGGPPIDQNLILFQNRAMKVRVEEQKIEINDREQKIKQLNTKIHQYKENISCLCRVWDQLNSGLDLLINRVDFENAMDNLLPKDNITESFEFLSSYITEPVTLDEKYTLDQSLQKKVQKTQSTFSKISKALEKEHTLSKFVFRLLKSKDGIKSNDIEKLLKEDNDKLSKQNQYIQNIYDKVQIQFKQLTDQTTHLADQAAIYQQNNKELKLELEKSQDELTIERKRVIKLQDETLRTPQVKIPSPSLGSNIPGGANNNNNNNNNSNNNNNINNNGNNMGGSGSSSLASSTNGINKQQSNDINGKELTHEELIAELQRQSDSRLLEARKLREEKAILLKELQQIQIDIRVIPEERIQNSMPYQVLRQRYQLVSDELDIHRNQCTKLQNDLAQATIGRRLEREALEAFEAHRRQNIERRVSQLEVESIELKGEKEKLVCLIEQRNPNVPSLQYIQESRLLLDKKDDEIKQLRKEIEQLKLDIEKYKAPKEEIERYKLLVQRDVESKNIEINKLLEKINTITKQNNDLKSNEQQLLQKESELTLSLNILKSNKNNININNLDKDNIEDNSKIKQQQEQQQQQHQKIDNNNKKEEEIKKEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQEEQKKDKEMIDIEKSTENIINNNNNNNTNEQKLNEINKNIENGNNENNNNNENTINNENTINNNNNENKDKIIFNLELNESKLKLELSTVKKQLEDITKSKEEYDNEIKEINEKFKAQIKELDITISQNKIQQESQKQELEALVMEIDSMGKAYEQMLEQNTRLTKQLSDKEDTHAHLMAENIKSQQTIRNSKEIQLAIEEKLNRNEEKLKSQGELMQKIEEKSNILQKQLSKVTEDLHSCSFDLEKHKRFVRENNAHSLELKTQLDHLSNLNAELKKKADDSIFALEREIDKAKRLDEEKQLLKKKLEKATSANNNNNNNNNNNNNNNNNNSSSSEEELKLINQRLRCTICNDRQKNYVIAKCFHVFCKECIYSNIDTRKRRCPSCNRAFAETDVHQIYY
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MSRSLLLLLLLLKVVAMTPSQRPPSCHEVRTAFQLQQVGRGRLVPEVPVEESDLEICQHKAPTCCTRKMEESYQAAVRREIAHNIQALNFELKFMIVSHKSNFKEGFTHLIDLAVNHTLSLFDSNFWLLEQEARDPVRELFTDISLYVLGEEIPVDAAVSRFFDALFPLVYKHLINPRMAPLPKEHLECLRLTRQDINPFGLYSQTMATRLSKSLWASRMMNQALNMVEHVINGTEQTVMTRECTRALVKMQYCPHCQGLTLIRPCVGYCLNVMRGCFATLAELDAPWRDFISLLEHLARQLSGSYDLELALLGIREMVKESIQYAEMNGSNISSVVEKVCGPLQESPAKPTLDVIVQMNVEDELPQVTKFPASGHLRSSLPLKASKSDRPRNMKRVSREFIKYMENSKAFYATLAERLCSGDLAVRDGSTCWDGEDVVESYTNIVVSSEFKAQANNPEVKVRGRNVLITNVINRLNHFIQTGSEKQISPDKNRIREGSGGDDKVEDADPSGDCDDEDGCQGSGDSSTRTGTKLIPDVSRKGNGTVNVLLSYPGATKISHNQKNLPGTGSRLKLSSALPLAALLFICQYI
The following text describes a protein:
Function:
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
Subcellular Localization:
Cytoplasm.
Sequence:
MGSEADDFLDLLYGEVVRLKSFPIPPPPDLELSTLGLEVEDTGKRPITASHPHITKDFLQQFKGQIFCKEQLLFFEHRGARVHMRVSFATQKAGNACRGKLVKQTEIHFFESDLFKVSDQKEVKMILRRDLNIHDLAAEMKSLGVGGFGNELKDVFSMLVVPRFIPQEYAREVRCKYKQGIIFHGPPGTGKTLIARAISKIVNGKLQIVRGPEIFSNFMGSSEAKIRAVFNSAINDLIEKGDKSPLHVIVFDELDSIAREKGINPSDTTADRVVNQLLTMIDGYSELSNVLLVGTTNQLELIDKALMRPGRFELHMEIGLPNEAGRKEILRINVKRLQWKGALSSSVNLDELAKETKGFSGAALAALIQTAFFLAVTRAVPENIADTVWADAKVEQEDIDRAFGKLKLTGVKSKVVLCLKESIRPNTYGAP
The following text describes a protein:
Function:
Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol. The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids. Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds. Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane. Involved in endoplasmic reticulum-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane. Acts as a negative regulator of platelet aggregation following secretion in the extracellular space. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals. Regulates endoplasmic reticulum-mitochondria Ca(2+) flux.
Miscellaneous:
MISCELLANEOUS: Mediates reduction of intermolecular disulfide bonds between chain A and B of Ricin toxin (Ricin A chain and Ricin B chain, respectively), thereby releasing and activating Ricin A chain.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Mitochondrion membrane; Single-pass type I membrane protein. Secreted. Note=Predominantly found in the endoplasmic reticulum. Secreted in the extracellular space following thrombin stimulation. Localizes to mitochondria-associated endoplasmic reticulum membrane (MAM); palmitoylation is required for MAM localization.
Sequence:
MAPSGSLAVPLAVLVLLLWGAPWTHGRRSNVRVITDENWRELLEGDWMIEFYAPWCPACQNLQPEWESFAEWGEDLEVNIAKVDVTEQPGLSGRFIITALPTIYHCKDGEFRRYQGPRTKKDFINFISDKEWKSIEPVSSWFGPGSVLMSSMSALFQLSMWIRTCHNYFIEDLGLPVWGSYTVFALATLFSGLLLGLCMIFVADCLCPSKRRRPQPYPYPSKKLLSESAQPLKKVEEEQEADEEDVSEEEAESKEGTNKDFPQNAIRQRSLGPSLATDKS
The following text describes a protein:
Function:
Proton-selective channel gated by extracellular protons.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLSKEEPACRQFHSREKTWGNEHNGKTVTQANNKEHKVPAVRRGDIGQREPAAHPASHIQGTMASENTGEQATCKDQYMDLDAPGNNLEHSWLHRHCEIPTTLHQRAKKTGRLFSGLFGLNLMFLGGTVVSSVALSNKAVPERDSQSFLCILMLLSSVWALYHLLFIRNQNGAVHHDHHAGAMWLKASLAIFGVCSIILSIFEIGHALLLQNCEILMDIVFFSIEIVFVSVQTVLLWVSCKDCVQMHHSVTRYGIMLTLATDILLWLTAVIDDSLEQDLEILQSNSTQDESNEMAQCQCPTDSMCWGLKQGYVTMFPFNIEYSLICATLLFIMWKNVGRREKLHSDPPRHTFQLRGIIYGPLIGGAALLVGISVFVQYQVEATSGMVSILSYHMYYGYKMIILAPMIVCSVAGIIAHSLREKEKKGQKETGRSDQDWLHMEDVGSENKNTDYSSGQYQSSQGDEKIQGYSLAQFALDNEKEKLEHRQGNTTKKHNTHQGKMKNYTRKLDVTLLFVSAVGQLGISYFSIIATVVTTPWTMLSALNFSNSLLLILQYLSQTMFIIESMRSIHEEEKEKPGHHEESHRRMSVQEMHKAPPSCLDAGHLGLSRRVVKEMAMFLMICNIMCWILGAFGAHPLYMNGLERQLYGSGIWLAILNIGLPLSVFYRMHSVGILLEVYLHA
The following text describes a protein:
Function:
Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'.
Subcellular Localization:
Nucleus.
Sequence:
MALLLTLTSPDLEGTWDTRDKDGFKAQEGPPLAVPEFPVCGLYRIYGVCGSFSSFFIIRCSLCALETLKSPQHDPLEIPEQSLKLIPLVSGKRELTRGQKAGEKPLAAGPGEEELLRGSAPHAQDTQSEELPPSCTISGEKKPPAVSGEATGADAGRLCPPPRSRAPHKDRTLARSRPQTQGEDCSLPVGEVKIGKRSYSPAPGKQKKPNAMGLAPTSSPGAPNSARATHNPVPCGSGRGPCHLANLLSTLAQSNQNRDHKQGPPEVTCQIRKKTRTLYRSDQLEELEKIFQEDHYPDSDKRREIAQTVGVTPQRIMVKGAGSLVAGWSGGGPTIETLELQSERSAVAWVWFQNRRAKWRKMEKLNGKESKDNPAAPGPASSQCSSAAEILPAVPMEPKPDPFPQESPLDTFPEPPMLLTSDQTLAPTQPSEGAQRVVTPPLFSPPPVRRADLPFPLGPVHTPQLMPLLMDVAGSDSSHKDGPCGSWGTSITLPPPCSYLEELEPQDYQQSNQPGPFQFSQAPQPPLFQSPQPKLPYLPTFPFSMPSSLTLPPPEDSLFMFPCGPSGGTSQGYCPGASSGQILMQPPAGNIGTASWSDPCLPELPFPGPFCPQALGHPPGGDGYFPDLFPTPCPQALGRQPSSALSWMPEGARPGTGPLLSKAKEEPPAASLDQPSALEEARGDDKNSHVP