lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Calmodulin-binding protein essential for pollen germination, but not necessary for microsporogenesis or gametogenesis.
Domain:
The calmodulin-binding domain (CBD) is located between A-448 and A-496.
Sequence:
MLGNQSADFSEKGEDEIVRQLCANGICMKTTEVEAKLDEGNIQEAESSLREGLSLNFEEARALLGRLEYQRGNLEGALRVFEGIDLQAAIQRLQVSVPLEKPATKKNRPREPQQSVSQHAANLVLEAIYLKAKSLQKLGRITEAAHECKSVLDSVEKIFQQGIPDAQVDNKLQETVSHAVELLPALWKESGDYQEAISAYRRALLSQWNLDNDCCARIQKDFAVFLLHSGVEASPPSLGSQIEGSYIPRNNIEEAILLLMILLKKFNLGKAKWDPSVFEHLTFALSLCSQTAVLAKQLEEVMPGVFSRIERWNTLALSYSAAGQNSAAVNLLRKSLHKHEQPDDLVALLLAAKLCSEEPSLAAEGTGYAQRAINNAQGMDEHLKGVGLRMLGLCLGKQAKVPTSDFERSRLQSESLKALDGAIAFEHNNPDLIFELGVQYAEQRNLKAASRYAKEFIDATGGSVLKGWRFLALVLSAQQRFSEAEVVTDAALDETAKWDQGPLLRLKAKLKISQSNPTEAVETYRYLLALVQAQRKSFGPLRTLSQMEEDKVNEFEVWHGLAYLYSSLSHWNDVEVCLKKAGELKQYSASMLHTEGRMWEGRKEFKPALAAFLDGLLLDGSSVPCKVAVGALLSERGKDHQPTLPVARSLLSDALRIDPTNRKAWYYLGMVHKSDGRIADATDCFQAASMLEESDPIESFSTIL
The following text describes a protein:
Function:
Contributes to DNA double-strand break (DSB) repair via somatic homologous recombination. Functions downstream of ATM.
Subcellular Localization:
Nucleus.
Sequence:
MSSRRSVKRSLVLDDDDDEDIFYNFKVLLPNGTSVKLTLKNPEPEISMQSFVNLVKKEYDNARKDCLLMSKRMKVDWNSGGKFHLESNGGKMKGIVRFAAFKPDLCHIIRLDDGSGIASTMYENLWDLTPDTDLLKELPENYSFETALADLIDNSLQAVWPYREGARKLISVDISGDHITVFDTGRGMDSSEGNSIDKWGKIGASLHRSQKTGAIGGNPPYLKPYFGMFGYGGPYASMFLGRCDFSFCLPILICIVLLRLTLFSVRRTLVSSKTKESKKVFTLQFKKEALIDNRSIVGKNWKTDGGMRDPSEEEMKLSPHGSFTKVEIFESEFDISKIYQLQCRLKDIYFPYIQFCLATIFLCDELSKTGRTERPVAFQVNGEDLAEIAGGEVAITNLHSKGQFFSFQIRFTLFGGKRKGTAQEANARLKFVYFPIVQGKESIEKILQSLEEEGCKVSESFQTFGRVSLRRLGRLLPEVRWDSIPFMQRGNRASTLQKSCRRVKCFVDLDAGFSPTPSKTDLASQNPFSVALRNFGSKSTEKEKDDDVNIVIHREGKSVSYAHLEEKYQEWVLEMHNTHDEEAASGLDEAVLIVGSLDKKALGILRDAVRVHKEVRRKEKTWKRGQNIKILRGAYAGIHNNNVYATIDYFLIEGFEDEAGGDTRILCRPIDRPENEGCKLSIIDGISKLEVQSSLSLPITIIDSGKCLPVDANEWNRKLDKQQEKAPSKIDLLDERDCRELKIDGELPIGNSVRAGKAPPKQIVAVVRPACFTSLTPSKKLDQKNIVKMDGEEMVMVVKLKSSDKNISSQRLFPTSRKGISGLYIFSLGSKFPNLFKKAGTYNFSFSIGNSIKCNKTVVVRPSSKAARWELDDNLESLPCNVRVGSSLPPFRIACFDKYKNKIPFTSVPSLEVELEASPGFLIKIDKLETNLINDGLILKIENMLVETDELDQIRPNYEATLEIRAMDNPFSVSVPCKVNPGPLKRVAVNNPKALENLLPDSTVEDFILELFDGYNNHVAEGTDVLIHIDGYRIEDWMGINRKVDSRGCINLSGILKVTEGYGKSVSLSVMSGNEVIFCKESQIDERQLRLVTELPDCCTAGTNLMNLIFQVTELDGSLDTSIHHDEKSGCFHTMSIESDSSSVESAIRYAFVHGSCKVSSLSLPENEGVFSCRVFHSRYPELQMSIKIQVTSAPTSEREESGYSTPHSKTTPPPESGIPSITNPWPTPCSQFGVLAIRSSSLALSSETSLMDMAQYTEDLKEKINIDEERRVELEERLKCLQAQREHAEQECSRLQASLEPLGAPFPECLSTKESMMKQIEEKHHDTAASVFCCLYRKAPPPRSLFLSQKGMFGVVALLGSVASTSLSRVLSEYLGKDTMLSLVCKSSQFGPKSDEYRKFQSEAASLGRSITNRFLVICLDATRPWRNGLVRNDPQKRLAMDNPYLPNGDPIPGFKGYAVNMIDLASEELDIQSSSGYGLRETLFYGVFRELQVYETAEHLEAALPHINGGDAVSLDGVIARENGFIYSGCCTPEVHFPITVTERQEKALVQLEITRDKKRKTEEMMTEENRSLRRLVKKLKKANEKYQNFTAMADS
The following text describes a protein:
Function:
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Sequence:
MKIISINNTEQFLKKIGTKDSSKNQKIVKSILKDVKKNGDVAVKKYEKKFSAKVSSLRVSQRDIASAYFKVSKEDISAIKLAKSRLSKAESAVRRQFKDITIKSNGTKLSKSFVPIDSVGCYVPGGAARYPSSAIMSVVPAKIAGVKRIVVVSPPNSSGNIDPLTIVAADLCGATEIYKTGGVQSIAALTYGTRSIKKVNKIVGPGGAFVTLAKYLVSNIVSIDMMAGPTELGIVIDSAADVDVAALDLISQAEHSSDTFCYALTTSNSIAKKIQSSVNSKLKDIQRVKIVKSSLESNGFIGVCKPSDIIDIANDLAPEHLEIISKNPKKWNKIKNPGLILYGKNSPSSASDYLLGSNHILPTNGFGKTRGSLSVLDFVKLLTKIETTKKDLQKISKSMKNLTLAEGLPNHYEAVRGRLK
The following text describes a protein:
Function:
Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKTKLRTISITDGGPPQQLNESRFKYVSACRIILQFVFCIASIILGFRTSEEISLVVFQFRHVEDALSFNWFDRGSRRVVGLTVAKGVSDLSLSGSSDSLVEPEEATFSSLPHLDARLPGPLAGSVKPTNWSTSTGVQVGRHKILIREWPHPDPVETMKAHNLIARVQLEQERLHGVPNWKPVIVITPTYDRMFQAVYLTGLMHTLSLVRGPVTWIVIEAGGKTSRTADLLAQARVDNVVHLEHSKSMPVYFESRWIMESHLRVEALRFVRKKKLEGVVVFADDSNVYSMEFFNLIQKVEWVGVLPLGVLGYAGFQDTSKKKRRRRGSLLLGVVHKGQVPPKLDLQVQTLTRNLDGALHGWHAHRPLPLDWDSGKGSTVLDDRLQWAGFVLNARAVWAPETVRPQWLKGWQDWARLEEGVYLDLRSIFNDETHVEPLAENNIVRHWWIRAEGRPDFKYPSRRGWAFDSQPQIVLPARSTPWREVDTSGKSAARQEKSTPSV
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MTATLDIATVQAFLLVADLQSFTRAAEALGTTQAAVSLKLQRLETLLRKRLVERSPRAVRLTADGAAFLDRARALMEAHDRALSGDTSTAQSLSLGISDHAAGPELVPLLERLHAMSSNLTLAVTIGFSREMQDAYDTGELDAVIVRQEGSRRGGEKLAEDEFCWFASRRFTLPKGEPLPLATLAPPCGVRAIAVRALDKAGLAWRERFVGGGVTAVVAAALAGLAIAPLARRIAPPGLIDIGPAHKLPKLGSSKVMLHSKVSDPAKLAALRAVAATFKSVAA
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MATQSVNAVIVDLPGDVNDDGDNSDCFIFSTPPLSARGSTKRDAISVENYDRDRKLQRLWVYPPHKTVIKSESPIYIDLDLYDDEDDDIRILCFAPPIHREKGQSSSSKTATFDCEICVDSKSIIESFRIGGCSHFYCNDCVSKYIAAKLQDNILSIECPVSGCSGRLEPDQCRQILPKEVFDRWGDALCEAVVMRSKKFYCPYKDCSALVFLEESEVKMKDSECPHCHRMVCVECGTQWHPEMTCEEFQKLAANERGRDDILLATMAKQKKWKRCPSCKFYIEKSQGCLYMKCRCGLAFCYNCGTPSRDHTHYCYNCKR
The following text describes a protein:
Function:
Controls the transcription of genes involved in arginine and lysine metabolism.
Sequence:
MKRPDYRTLQALDAVIRERGFERAAQKLCITQSAVSQRIKQLENMFGQPLLVRTVPPRPTEQGQKLLALLRQVELLEEEWLGDEQTGSTPLLLSLAVNADSLATWLLPALAPVLADSPIRLNLQVEDETRTQERLRRGEVVGAVSIQHQALPSCLVDKLGALDYLFVASKPFAERYFPNGVTRSSLLKAPAVAFDHLDDMHQAFLQQNFDLPPGSVPCHIVNSSEAFVQLARQGTTCCMIPHLQIEKELESGELINLTPGLLQRRMLYWHRFAPESRMMRKVTDALLEYGHKVLRQD
The following text describes a protein:
Function:
Involved in spore wall assembly.
Miscellaneous:
MISCELLANEOUS: Present with 155 molecules/cell in log phase SD medium.
Subcellular Localization:
Prospore membrane; Multi-pass membrane protein. Lipid droplet. Spore wall. Note=Localizes to the ascal side of growing prospore membranes in mid-meiosis II and to the spore wall in post-meiotic cells. Localizes to a specific subset of lipid droplets associated with the exterior surface of the spore throughout spore wall formation.
Sequence:
MSTRPQPDWYYHRHPYASTPLAEGEEPQLLPIQDQGNHKKSKIWMAYKAPIVRWYKNAMLVKDNFWKDLESSHQIIWYPYKGISESVGNSDYLHLFFLIFGYYLLNLLLIVAFTSILAWSLLVCIYLPFLGLFALPLAYMQTILISTTLCNSMVKGTDFVLFTRIYGVTFARKGLTELSEACETISFTPFVYRRSHRLGGLFSKRFYLVSLPQFFIFFFWYIFIAFMFLLLLLVPIVGPITINMLPFSPGMGFYYFEPYFVDVLHLDSRKLSKVYYKGFAKWLLYSISSGLLESIPILGGLFIGTNAVGASLWIVKEIKDRDQPAVPPSPPAEPEEPTVGSYAPPIQQSIAHINPP
The following text describes a protein:
Function:
Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. Targets the RZZ complex to the kinetochore at prometaphase (By similarity). Recruits MAD2L1 to the kinetochore, but is not required for BUB1B localization. In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I. In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity).
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase (By similarity). Localizes to kinetochores both during mitosis and meiosis (By similarity).
Sequence:
MADAEKNAVAEKNAVAEENAVAEENAVADKNATKEVLAEAASVLEPVGLPEEAELPAKIMEEFMRNSRKKDKLLCSQLQVVNFLQTFLAQEDNTDQNPDALASEDTSRQKATETKEQWKELKATYMDHVDVIKCALSEALPQVKEAHRKYTELQKAFEQLEAKKRVLEEKLQLAQKQWVLQQKRLQNLTKISAEVKRRRKRALEKLDGSHQELETLKQQAGQEQEKLQRNQSYLQLLCSLQNKLVISESKADDKDVKGPALPPKSP
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Cell membrane. Endomembrane system; Multi-pass membrane protein.
Sequence:
MSTLLPTSTTVREAENRIASQQHHRRDAGTLFVLKSKGSWIHCGYHLITSIVSPSLLSLPYALTFLGWKAGILCLVIGALVSFYSFSLICLVLEQHAQLGNRQLLYRDMARDILGPRWARFLVGPIQFALCYNNQVLCALLGGQCMKAIYLLLNPNGTMKLYEFVVIFGCFMLILAQMPSFHSLRHINLVSLVMCLSYSACATAASIYIGKSSNGPEKDYSLIGDTTNRLFGIFNAIPIIANTYGSGIVPEIQATLAPPVKGKMLKGLCVCYVIVALSFFSVAISGYWAFGNQASGLIFSNFIDTNNKPLAPKWLIYLPNICTIAQLLANGVEYLQPTNVILEQIFGDPESPEFSPRNVIPRLISRSFAVITATTIAAMLPFFGDMNSLIGAFCYMPLDFILPVISLNLTFKAIQEKLHLLVDCNHCCRILNIGSYGSDFDSEADCS
The following text describes a protein:
Function:
Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Likely functions as an accessory factor.
Sequence:
MLNRQRLLLGVAGRLLPLAAKVPRGLQHLVLQRVANRLFAQPLEEGAFDLLEGRWLRLEVRDLGVGWCVTRVPGGLRLVERPRASVTIRGDWRDFLLLASRHEDPDTLFFRRRLVIEGDTELGLAVKNLLDSLDPEHLPPWLWNAVERAGRAVQEERGEAPQGPVQGARGG
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Sequence:
GGQQRAAPCPRGGPGGQGQPRAEEAGTGQGHRGGHRPGAAVGAAQHLYQGLGVSGGGPGLGPADLQTRKARRLKQAKEEAQMEVEQYRREREQEFQSKQQAAMGSQGNLSAEVEQATRRQVQGMQSSQQRNRERVLAQLLGMVCDVRAQVHPNYRIAA
The following text describes a protein:
Function:
Probable 2-oxoglutarate-dependent dioxygenase that may be involved in glucosinolates biosynthesis. May play a role in the production of aliphatic glucosinolates.
Sequence:
MNSLTQSKIPVLNIEGLKPGTESWIMACHKVRHTLEEYGCFMVVSDELSQDFMKEVYANMKALFDLPLETKMKNTSAKAFHGYVGATHTRPLYESMGIQQPTSLDEVVSFANLMWPSGNDQFSKTIHSYANLVVKLENQVRKMVFESYGLEKYYESFNESVTYVLKPNKYRPPKSNEVNVGAKMHTDKNLFSILSQNQMNGLEVQIKDDEWMAVEFPPSSFFLMATDVFMAWSNGRIKALRHRVVMNGQEDRYSIALFSFKKGIVEIPEELVDEDHPPRFKSFDNYKFIEFYVKNPPPYHDERVIELFCGN
The following text describes a protein:
Function:
During meiotic DNA recombination, binds to and may help activate DNA double-strand break (DSB) hotspot sites.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome. Note=Localizes to chromosomal double-strand break (DSB) hotspot sites during the meiotic cell cycle.
Sequence:
MSEIITSLQTELSNRHANMVSEAVLAFSEHHDSALHSYFLNARVKDVILESLRTTEEKLRALDKLQLDASKNLSNLLVEYNSINAELESVNSKISSISSQEYALEEFQALSQNFEKNLVQHRRNSQNKLKCAMEKLKMIETSTHKAILDNF
The following text describes a protein:
Function:
Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (By similarity); [Isoform 2]: Has a role in spermiogenesis.
Subcellular Localization:
Nucleus. Cytoplasm. Membrane. Mitochondrion. Note=A small fraction localizes at membranes. Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis (By similarity). PTEN promotes cytoplasmic localization (By similarity); [Isoform 2]: Nucleus. Cytoplasm. Note=Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta).
Sequence:
MDVADPQPLGLFPEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHRNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAVDDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGRGDFTIPCDCAPPLSDLLRGMLEYEPAKRFSIRQIRQHSWFRKKHPLAEALVPIPPSPDTKDRWRSMTVVPYLEDLHGRAEEEEDEDLFDIEDGIIYTQDFTVPGQVLEEEVGQNGQSHSLPKAVCVNGTEPQLSSKVKPEGRPGAANPARKVCSSNKIRRLSACKQQ
The following text describes a protein:
Function:
Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAHSHSHADSHLPKDNNARRLLFAFIVTAGFMLLEVVGGILSGSLALLADAGHMLTDAAALLFALLAVQFSRRPPTVRHTFGWLRLTTLAAFVNAIALVVITLLIVWEAIERFYTPRPVAGNLMMVIAVAGLLANLFAFWILHRGSDEKNLNVRAAALHVMGDLLGSVGAIVAALIIIWTGWTPADPILSILVSVLVLRSAWRLLKDSVNELLEGAPVSLDINALQRHLSREIPEVRNVHHVHVWMVGEKPVMTLHAQVIPPHDHDALLERIQDFLMHEYHIAHATIQMEYQVCHGPDCHLNQTSSGHVHHH
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cytoplasm. Cell projection, axon. Cell projection, rhabdomere.
Sequence:
MPKIDPETQKLYDEINGMIQKFKDDQKSKADCTLADKCGDMGDVPKIRFSSKKILKGHINKVNSVHFAGDSRHCVTGSLDGKLIIWDTWTANKVQIIPLRSAWVMTVAFSPSGNFVACGGMDNQCTVYDVNNRDASGVAKMVKELMGYEGFLSSCRFLDDGHLITGSGDMKICHWDLEKGVKTMDFNGHAGDIAGLSLSPDMKTYITGSVDKTAKLWDVREEGHKQMFFGHDMDVSSVCYHPSGFGFASCSEDQTARMYDLRADQQIAQYEPPQKNTGFTSCALSTSGRYLMCGGIEGNVHSWDTMKQRHTGTLSGHENRITCISLCPNGMCLASTSWDQQVRLWL
The following text describes a protein:
Function:
Involved in ribosomal large subunit assembly.
Subcellular Localization:
Nucleus.
Sequence:
MSSSSAEKSELPVTVEKPIPVTYDLGNLAVFDSNALDRNDLDSSNANREEHLRALTRDNVQLLINQILSLPIKSTTDSTGSGQSSSIALVRLPEPTTDLPREKPLPKPKAPTKWELFAAKKNIKPKEKSGKMVYDEAAGEWVPKWGYKGANKKLDDQWLVEVDDKVKGTEDELIDPRTLSRAERKKLIKKNELQHKRNLKNAVSK
The following text describes a protein:
Function:
May be involved in retrograde transport from early and late endosomes to late Golgi (By similarity). Required during spermatogenesis for sperm individualization.
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MATTRSAGGAATSVDTGPAAGNSGIRKLSTASVGGIAGGVAPSWQSCYYCTREHFKSISDFVNHLRNRHCTREGGSFVCRYGFNGVCASLPLDGVSDRDYDAHVAKYHVNQHTREMPPEWGVYSAAQNLPAVLNDPSRGKQSNLFTKKWGEHFVERSHVPPSPRLPDITHADFTVYLGSIGKRYRWHERRQQQLERDKPLENGAQGAPGPGTGGQTPTHLSSVPEIFLKSQLQLHHPATFKQVFPNYMQTSASSPESHQQTGRQLQEQLSHYLDMVEVKIAQQVSQKSAAFFHAMTTQHAILAEMEQAADQVRQLRAALAELHSHSVVDSFKVLRFAQRRQHYNLTLDKLRLMATVHKTQPMLQLLLGTQDYVAALDLIGTTQEILSAELLGIHCFKHLPMQLSEMEKLIDKMLTTEFERYAAADLNRPLTDALRETDSVCAEEDKLVAIVMGLLRKQNFSFVQAYQQEAIATIRAIIKQLLIEVLARSDSDQEISLTGHGEQALELTLPEWIALLQRSSQALVSILERIKTVVGIMQQTADAAVGAQDAVNLIDSEAFLSPGHHEQLKNQLQQLLQAVCHYCHERCANIVSPQSLERSSASEQELFQLSEIVDHFGETTRSICGVASVPLQLALKVQASRYAQRFHSERKQKLSLLLDQERWRQVDIPHEFQRIIERMAAGDYAKPEMGNLISNGAGNPVLLVEGKQPYTLVSASLMLIRMLYEYGCSAHRLPLLASYHARNVVDLLRCFNSRSCQLIIGAGAMRVAGLKTITSTNLALVSRALQLVLWLLPKLKEHFQAMSGYETIERDYQGHIKEIENKIHGIVSERLAAQLDAWEARPPIPSQTFRHISRHLVKLHEAIAGVLPEAQIHEIYGVVHRNFKDKLREQLLKLNVNNNGGPQHGVVTSELTFYMETLRTLKALPAEQLDNGILEEIWLY
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MASTSAATPLKNKRKFENGKKKPKTLKDEFGEKLDIKPVIVPPKPADEYDYDSSDEEDLRNTIGNIPIKWYDDEDHIGYDKFGEKIAKPAKKGEIETFLEKMEDPDYWRKVFDKQTGTDVKLTDEQIEKIHNIATGKYPTIGYNPYEPFLDIFSSQKEIHPIDNRPEPKSRFIPSKDEMRMVSRMVHAIKMGWAKGPRAKKEEHKSYDLWASEDALDNVTKSQLSRMRVHMPAPKVALPTHAESYNPPEEYIFDDEERKKWEEAEKEDRVLNFMPSKYDALRKVPQYDKFITERFERCLDLYLAPRQRKMRIHADPTDLLPDLPNPNDLRPFPTTLAFYMRGHTGQVRAITVEPERGELLASGGEDGTVRIWMIATGRCIKTFQMDGEVTSVSFSPVADRTLLAVAYEGKYVAILNTGCGDRLHVQQTEALLAETPTDAQEDGAVVTWRKSKEKLMLKMPNEVRQVTWHSKGDYFASVAIDDIAKSVYVHQLSKAKSQCPFQKRKGHVQAVTFHPTQARLFVATKIHVREYDLARCVLVKKLITGCKHISTMATDANGENLFLGGLDRRFCWMDLQMGNKPWKKLKHHTAAVRSVAYHKKYPLLATVSDDGTAMVYYARIYTDFVKDNELYPVKRLRAHEKTPNDLCMLHTTWHPTQPWLITAGADGTIALFTY
The following text describes a protein:
Function:
Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MDNQNNNNALANGDSQFTMPKVIDYLQNEWLKFEVDRAHWISEKAELTNRILKLESERKLFESHKFDLCRRVKMLEYALQQERLKNNSLLQQQQKVIEKVEEEEEEDDKIPKNREPPKKSKDNTTRLIIRKYLREMGYNDLIVSKSLQTEFENDSQNIDNDTTNTIDDTNDTTVKTILNLKDINNNNSNNNNKNQTTTTTTTSPSPSPSPSTSTSTSTSSNKTDNTTTTTTNGNGYNSNTIISPPSSSSSSSSSSSSSSSQSQPQPQLQSSLSELINNTTDLSQSLDSLSSASSGYEYDSLLDNLKQLDNSSVSSNSGNNSINSSSDSLDTSKQSQEDPNNVTISKQQQQEQQQQQESDEQSFNSFNEDIFNKLTANSKGRMKIKGLGNLKNYKKEHMGEEGNLSLPDQNTEEKSTPTTKSSSSSSSSSTGSTRKKKSSSSSSSGSSSSNSNTMNSELMGLGASDLNDITLDDGSKGGNDSAAPRVWKFKHSLKSHFDGVRSIQFHPNEPIMISASEDNSIKVWNLNHLVPTKKSPSPEIEPLYTIRGHTGPVFTSEWNQINGEYSNYQSFFSAGYDMIIRQWSLPSSDIDSYLQHGKILPYLEKEFIGGHQDGIWDLLSIPNTPNLLSSSADGTVSLWNTTTSEQLYTLQHSNGLSYIPTSIALPATENNRKLLTSYNDGSILLFDLETQQIISQLKQGSSNNNNNNNNNSQINKIVSHPFMPLAMTGSEDHKIEFFDLNSNTVVHSMIAHSNSISSLTIDPSGLYIASCAHDSSIRFWDISSKTCIQDLNSHRPKYDESIHCIKYHPNKGYFASGGADSVIRILN
The following text describes a protein:
Function:
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MPNGSLDRFIFGNTIPSNADTTLKWETRHNIICGVARALDYLHNGCEKRVIHRDIKASNIMLDSDFNARLGDFGLARTVQLNEKTHHSTKEIAGTPGYMSPESFHTGKATVETDVYAFGVLILEVVSGRKPGHQNEQNNYYRSIVEWVWEHHRMEQITDVIYLRLNKDFHEDQARCILMLGLACCHPNPFERPSMRTALQVLTGEVAAPAVPTEMPAFMWPAAPPVIREEMDNSITGAAATSVLPGGPSSSALQFVALSLALFKMASLLKVSANGFRSEKLPSLSKGNRRQGIVAKKAAFGSIRAAMSLSMSTTAVQHNQKSTSLDLAIPIMVNSCTGKMGKAVIKAADSAGLHIVPVSFGAEKESGQTIEMCGKEILVHGPSERESILASVFHEYPNLVMVDYSVPAAVNDNAELYSKVGVPFVMGTTGGDRDRLYKTVEDSNVYAVISPQMGKQVVAFLAAMEIMAEQFPGAFSGYSLQVMESHQASKLDTSGTAKAVISCFQKLGVSFDMDQIQMIRDPKQQIEMVGVPEEHLAGHAFHLYCLTSPDETVSFEFQHNVCGRSIYAEGTVDAVLFLAKKVRFEGITATCSANNRFSQRPTSASTI
The following text describes a protein:
Function:
Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the removal of methyl group from the carbomethoxy group of rhodomycin D (10-carbomethoxy-13-deoxycarminomycin) and 4-O-methylrhodomycin D to yield 10-carboxy-13-deoxycarminomycin and 10-carboxy-13-deoxydaunorubicin, respectively. Could be also involved in the decarboxylation of 10-carboxy-13-deoxycarminomycin and 10-carboxy-13-deoxydaunorubicin to yield 13-deoxycarminomycin and 13-deoxydaunorubicin, respectively. It seems that DnrK may influence the ability of DnrP to carry out the decarboxylation (Probable).
Sequence:
MPTRMITNDEVTLWSEGLGDPADAPLLLIAGGNLSAKSWPDEFVERLVAAGHFVIRYDHRDTGRSSRCDFALHPYGFDELAADALAVLDGWQVRAAHVVGMSLGNTIGQLLALDAPERLLTLTVMLGGALDVDFDADLEAALKGEPSVSGLPVPSQRFLDMMTMLQQPAETDEELLERRVEKWRLLNGEGVPFDADEFRRRELLAAGHAGTFDEPIVHHMIPLPPVSRGAELSRVTTPVLAIQAMCDPAAPPPHARHLANRIPGARVVEIENMGHALPLAVHEPLAAAICAHTRAATV
The following text describes a protein:
Function:
May be required for ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MNANQAAESNLLASNQQKELEDLPKDYPLSTSEDEGDKDEERKHQKLLESISSLNGKDRQKLADRSEASLKVSEFSVSSEGSGEKLVLSDLLEPVKTSSSLAAVKKQLNRVKSKKTVELPLHREEIERIHREVAFNKSSQILSKWDPVVLKNRQAEQLVFPLSKPQSAFAPIEHVVNGWKAGTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLKAMSLEEVKMRRAELQRARALQSYYEARARREKRIKSKKYHRILKKGKAKQALKDFEKLQKVNPAAALEELEKLDKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLARNKELTQKVRAASESEEEGEGQEEEEEPLVPDLVNEVQIKANGLNPWMFRNHFIDAKEAEVQKDLEDPAEPEAQETSESEEEKAVVEEETLLKEFEERRSLRQKSELNHMAEPVHRRVTKDPSSQEVLSDLRALCQKLRTENHQSGKQELSSARTAQREEPAREEEEPMLLQRPERARTLDELEELGREGCVENEELPRTAVEGLQLEKNLSNHIGAPKEKKRKEQMIDLQNLLTTKSPSVKSLAVPTTVQELEDEEERDQRQIIKEAFAGDDVIRDFLKEKREAVEASKPKDLDLTLPGWGEWGGIGLKPSAKKRRRFLIKAPEGPPRKDKNLPNVIINEKRNTHAAAHQVQVLPHPFTHHQQFERTIQTPVGSTWNTQRAFQKLTMPKVVTKPGHIIKPIKAEDVGYRSSSRSDLSVVQRNPKRLSIRHKKHLENNCVD
The following text describes a protein:
Function:
Required for correct meiotic chromosome segregation. Appears to also have role in sporulation.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MLRFGIKTWKRSVLAIRRSSTAPHVQIISNLQKKLLNELYSLRRLVDDNSPATIRVGNVSLLLSKSNIRRRIALQALSSSAEDVACVKQITHALLAAPFMPESKELKYAMDHNGLNPLYISFGTNALFERNARYSTSHLFLPSDFLQVNNLEIIHLPPGTVDSDILASCHARYICSTSYLRMTSSDFTTADTLVLDIDPKLHSLLKNEKSIIPVSSSAALKATKALQDDPHNFQNYQNQWEQSGFQQLRTNMTPTSDLEICKRFLNYLCCSFSLTKAEKDLVRATEFSNSMLISIEKWAKYCDVDLQEFEKKLQKFWKNFGTLKLYSNIESLPASLKQLIKDEYLQKSKLELSFILGELSKNGDDKNNFELAMKDFGTFQNSRMSAVDQALQPLRRKTLYTTAFQGLGALGSLYLYFVSHFSLYNAFSVFSVCGVFGLYYLQSSYRSWKKEYWKELLEEGRKFERQLCRNVFGRSSFYVQQKTAAEKKEHISLIMKKLTKTLDLMKEFQLQSSFSDSPTASKKQLL