lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVKKSRRRGAAQWAAVRAQAGLTATDENEDDLGLPPSPGDSSYYQDQVDEFHEARSRAVLAKGWNEVESGEEDGDEEEEVLPLDIDDGDDEDGESSEEEEVGEDDDGGSSVQSEAEASVDPSLSWGQRKKLYYDTDYGSKSRGRQSQQEVEEEEREEEEEAQIIQRRLAQALQEDDFGVAWVEAFAKPVPQVDEAETRVVKDLAKVSVKEKLKMLKKESPELLELIEDLQAKLTEVKDELEPLLQLVEKGVIPTGRGSEYLKTKYNLYLNYCANISFYLILKARRVPAHGHPVIERLVTYRNLINKLSVVDQKLSSEIRHLLTAKDGAVKKEMTPKAKLTKTKPKSVKQAAAVALTDEPDFDGAALKYYKEMEDRQELKRKKEENSAEEQALEEQNAKRAITYQIAKNRGLTPRRKKIDRNPRVKHREKFRKAKIRRRGQVREVRREEQRYSGELSGIRAGVKKSIKLK
The following text describes a protein:
Function:
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
Sequence:
MEVVVVGDAQAMAGRVPTVMHVRCPDRLREGVYRQVLELLTDLSPVVQALPPTAALVELKGALRYHGSEVHRLGEVLRVRTLSRLGVDVRVGIGPSITIAATASAQVPLPGGVLTVAPDDVTDWLAPLPGEALHGLGPRQAGALHEYGIHTVGLLAAVSPETVQRLLGGKAGRLAADRARGRDPRPVVPRALPAAATVRMRFDRHVLDGADVRAALLDLVVQLGRLLRRRGQAARAVSLTLQFAGGGSWEKSRRLPEPSAHDEDLRTMAYRLIDAAGLQRGRLTGLFLKADDLVDADRVAQQISLDQAREARLVAEATVDRVRDKFGPGVIGPAATARRAS
The following text describes a protein:
Function:
May be involved in environmental stress response.
Sequence:
MARRGTEAFPYLGAHCDEPDCNQLDFLPFDCDGCGKVFCAAHRTYREHGCAKAADQGRTVVVCPDCGDAIERTAPGQDEKAVLEAHARSRRCDPARKRKPRCPARRCKEPLTFSNTSECKACGLKVCLRHRFPADHDCAGKSVGASKAAAAAAARRAGGECAKDAKKGSGGWTLPAAVRNLKIF
The following text describes a protein:
Function:
Catalyzes the reversible conversion of 2-phosphoglycerate (2-PG) into phosphoenolpyruvate (PEP). It is essential for the degradation of carbohydrates via glycolysis.
Subcellular Localization:
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface.
Sequence:
MAKIINVIGREIMDSRGNPTVEAEVHLEGGFIGMAAAPSGASTGSREALELRDGDKSRYLGKGVLTAVANVNGPIRTALIGKDATAQAELDQIMIDLDGTENKDKLGANAILAVSLAAAKAAAAFKGMPLYAHIAELNGTPGQYAMPVPMMNILNGGEHADNNVDIQEFMVQPVGAKNFREALRMGAEIFHTLKKVLHGKGLSTSVGDEGGFAPNLSSNADALAVIKEAVELAGYKLGTDVTLALDCAASEFYKDGKYDLAGEGKVFDSNGFSDFLKSLTEQYPIVSIEDGLDESDWDGWAYQTQIMGDKIQLVGDDLFVTNTKILTRGIENGIANSILIKFNQIGSLTETLAAIRMAKAAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSLCRSDRVAKYNQLLRIEEQLGEKAPYRGLKEIKGQA
The following text describes a protein:
Function:
Involved in the lipid biosynthesis. Catalyzes the formation of unsaturated archaetidylserine from CDP-unsaturated archaeol and L-serine. Activity with ester-linked substrate analogs containing straight aliphatic chains (typical bacterial substrates) is two to three times higher than that with the corresponding ether-type substrate (typical archaeal substrates). Both enantiomers of CDP-unsaturated archaeols with ether-linked geranylgeranyl chains and CDP-saturated archaeol with ether-linked phytanyl chains are similarly active. The enzyme also accepts D-serine, although activity is only about third of that with L-serine.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MMNDKKITSFIALPDLLSMLNASSGYLSILLSIDGSLNAACILMLLAVLFDSLDGWVARKTGRIDIHGFGKNMDSLSDVISFGVAPAILIYSAAVDFRYINILVGPLIVLCGILRLSRFNVLTGGGKNFTGLPIPVAAVTISSFYLTGFYSELSAAFIMIAVSVLMISSIEYPRVDGMGASTALILIIATIISVAAVEILQAASVVAGPVAIILFIATLTYIAVPILPKRDVI
The following text describes a protein:
Function:
Mediates both basal and acquired thermotolerance.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAERLLQSMSRVAGRCHPDCVKASDEQEDYHASQNAALVAVNLISSARLILKLDAEFTEYSAQFLMDNAGKEDDPGEVDQQRNQVTTENCLRYLAENVWTKKENGQGGMDQQRPVLTVKDCLELAFKKGLPRREHWAHLGCTFKAPPFACQIPRVPVKGEVVEVKTFDEAFKLLVHQPIGAKLHLFSPQIDNVGEGVYKGLTTGNETHYVGLRDVLIASVEEFEGDSVAIVKICYKKKLSFIKVSLSVRFLSVAHDGDKSKFIAPTGLLVDFCVPRLSIN
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MVGKRHHGSSNMAVLLQSQGMYKEFSGPLFAPGTPSSGSLGSWSLADLKDGHGNSLERPLFRPVELDEIGDDDSGEYPHQPDKKRRLTTCQVQFLEKSFELENKLEPERKLQIAKVLGLKPRQIAVWFQNRRARWKTKQIEKDYESLKSSYDALKMDHDSLVKEKEDLKAEVLSLTKRLLKEENGSLESFEPKRLPDNLQNLDSTLAFEVKKLHGQTMLCKQEDISSANSAILDSESPHHTHEGDCSMLMELNSYSNAFRLDHSDHSQIGDVDDVKHCNFLSPEDTSCGSEFHVAEQVFWLWP
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MASATRTSQAEPWDDPHHGMEGGIWDLEYVYQLQLEEVMAASIAGMMREEETIHDNPVEVGVVEARIGGIEAVVEEEEVNEVGGERVEEEEEEEVDDGSVVDCEQEHDIEVRAVKTPEGHVGIGALITRNDSVLWRESKYVGIGMSWHVAEYGGVLDAMEVAERLGLRFLNVFVSSRVVSEQVNGFWKPKQTNQWMLLYQVQDAMQNFSSFGIRSWPKGSYNNFVTQLAQAAITNHLIGDASSSYSGASTAGAFDGVFHPNVTSHASTSAYSSNSRRESKENCLICLEDKLPSEMATVKKCLHEFCDACLRRHAEVQVQASQVPIRCPESGCSEELEYPEECKQYLTVEVFNILTKRLTEARVPEGDRVYCPYTNCSALMDKGGLDPPGQSTSVAPNKLSTYQKVACAECRRSFCLECRVPWHKNRSCQEYQNLPPDLRDAEESNLYKLAQNQKWQRCKKCRRMIELAEGCYHMTCRCGYEFCYTCGTEWKNKKQQCQCKLWDERNIIRTPRESDDESEDDLFFGDDGDDDNMLVDDFFGYDDEEEFDDVDYDWVMTDVGNPFRGFELVGELHGVNRMFDGLGLEPTVPHQIPFANRLYKTKLCRYYLRPGGCNDGRLCNFAHGEHELRHV
The following text describes a protein:
Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the stereospecific sulfate conjugation of 24-epibrassinosteroids. Preferred substrates are 24-epicathasterone and 6-deoxo-24-epicathasterone. Low activity with 22-deoxy-24-epiteasterone. No activity with 24-epimers catasterone and brassinolide. Sulfonates salicylic acid. May be involved in detoxification. Enhances plant response to pathogen infection and contributes to long distance signaling in systemic acquired resistance (SAR).
Subcellular Localization:
Cytoplasm.
Sequence:
MSSSSSVPAYLGDEDLTQETRALISSLPKEKGWLVSEIYEFQGLWHTQAILQGILICQKRFEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKTFFRKGEIGGWRDTLSESLAEEIDRTIEEKFKGSGLKFSS
The following text describes a protein:
Function:
Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells. Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells. May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence. May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose. However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MLSDELESKPELLVQFVQNTSIPLGQGLVESEPKDITCLSLLPVTETSECSRLVLPDDTPSPTCKEVPSSAVLRSLQVNLGPDGEETRSHTVQKSPELLSTPESPSLLQDLQPSDNTSFILLNLTRAGLGSSAEHLVFVQDEAEDSGNDFLSSDSADSSMPWFIRVQELAHDSLIAATRAQLAKSAKASSNGENVHLGSGEGQPKDSGSLPHLPQEEKRLQCTVEGCDRTFVWPAHFKYHLKTHRNDRSFICPAEGCGKSFYVLQRLKVHMRTHNGEKPFVCPELGCGKQFTTAGNLKNHLRIHTGEKPFLCEAEGCGRSFAEYSSLRKHLLVHSGMKPHQCQVCGKTFSQSGSRNVHVRKHHSRMGATGNREREQTAEPLMGSSLLEETSVHSKSLVSLNSQPSLGVESLHLPDTNTILGVEEEVLAEGASRSLSSAPEVVLPQSHHLVPMSTGRQSYEVSAITVNLELLKQGGILERWTS
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGFVSLLLVASSPVVEVLLIAVLGAYLASGHGHKVLLGASARTDINRVVYAVFTPALMLSSLARTVTLRDAVSWWFMPVNIGIIFLAGGLLGWAAVFLLRPPQHLRGLVVASCSAANFGNLLLIMIPAVCREEGNPFAEDGGAGVCTDRGLSYASFSMALGGLYIWTHTYSVMKRSSEIYRKMNHESTLASAVAHHGHDEAAHDDPKKDSLRQEEEEEEDNQLEEPSWNDDEEEGLVSQPSSDSFVVLDHEREQRQALLMPLVSSYHLQHSGGNKISVWDKLKHGTHQILEELTAPPTVSAVLGFSVGAVPWLRSAFIGDGAPLRVVQDALKILGDGTIPCITLILGGNLTKGVRKTAVSRWIIAAIIGIRYVALPLIGVAAVKSARELGFLPPDPLYQYVLMLQFALPPAMSIGTMAQLYDVAQEECSVIFLWTYLVAALALTLWSTIFMSILS
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MNSIIHAYSDPIYNHNSQTNMSVEGRVKQIVAVLVVAVVFAPPAAVSGELVVGFYKNTCPKAEALVQQAVSRAYLTNPGIAPGIIRLLYHDCFVEGCDASVLLDVSADGSALVEKDANISQSLRGFEAIDFAKASVEEECPGVVSCSDILNFAARDSVELTGGITWDVPAGRRDTRISIKDNIHGNFPGILSYKGGVELNGLLKSFTKKGLTPEDMAVLSGAHSLGRSHCLAFIDRLYEDHYSPDSPPLTDPTMSEAYAHLLRRICRPGFLDNNTTTFLDMITPNTLDNKFYLGLLNNLGLLMTDQALTQRRNLMAVVKKSASNETWWRKEFASAMVKMSKIEVLEGTLGEIRTNCRFPNGLHTIQRNQIDDSNLQIS
The following text describes a protein:
Function:
Synthesis of fructose 2,6-bisphosphate.
Sequence:
MGGSSDSDSHDGYLTSEYNSSNSLFSLNTGNSYSSASLDRATLDCQDSVFFDNHKSSLLSTEVPRFISNDPLHLPITLNYKRDNADPTYTNGKVNKFMIVLIGLPATGKSTISSHLIQCLKNNPLTNSLRCKVFNAGKIRRQISCATISKPLLLSNTSSEDLFNPKNNDKKETYARITLQKLFHEINNDECDVGIFDATNSTIERRRFIFEEVCSFNTDELSSFNLVPIILQVSCFNRSFIKYNIHNKSFNEDYLDKPYELAIKDFAKRLKHYYSQFTPFSLDEFNQIHRYISQHEEIDTSLFFFNVINAGVVEPHSLNQSHYPSTCGKQIRDTIMVIENFINHYSQMFGFEYIEAVKLFFESFGNSSEETLTTLDSVVNDKFFDDLQSLIESNGFA
The following text describes a protein:
Function:
Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine. May be dispensable for pharyngeal muscle organization in the adult. Probably phosphorylates netrin receptor unc-5, to regulate distal tip cell (DTC) migration during gonad development and in axon repulsion. Plays a role in the migration of the QR neuroblast, a precursor of the AVM neuron, and in the migration of the axon cone of AVM, ALM, CAN and PVM neurons. May act downstream of migratory protein mig-13 to control AVM neuron migration. Probably downstream of integrin ina-1/pat-3, plays a role in the clearance of apoptotic cells during mid-embryogenesis. Phosphorylates ced-1 at 'Tyr-1019' which promotes ced-1 proteasomal degradation, maintaining appropriate ced-1 levels for apoptotic cell clearance.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, phagocytic cup. Note=Co-localizes with ina-1 at the site of the phagosomal cup formation during apoptotic cell engulfment.
Sequence:
MGCLFSKERRSGGSDMGVSERIDVSRFQTPQQQTVFHVNNGGNEGTISQLNGTSDGMMGNGRGGGGGGGAQERETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDGSTLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPNYAPPSA
The following text describes a protein:
Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MRSLVVVVLALLAVSQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSDLRHHFFFLNPWASASNVSHTVVLRPLKAGYFNFTSATITYLAQEDGPVVIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGIPLLLWYSSKRKYDTPKPKKN
The following text describes a protein:
Function:
Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MEVPRLRVKLELLLLAYTTANSNRGSRLHLRPTPRQRRILNSLSEARDRTRVLMDPSQICFCCTTTGTLVLVFDIGYLSVTPPLFQSLEPLPASGPDFGGLGEEAEFVEVEPEAKQEILENKDVVVQHVHFDGLGRTKDDIIMCEIGDVFKAKNLIEVMRKSHEAREKLLRLGIFRQVDVLIDTCQGDDALPNGLDVTFEVMELRRLTGSYNTMVGNNEGSMVLGLKLPNLLGRAEKVTFQFSYGTKETSYGLSFFKPQPGNFERNFSVNLYKVTGQFPWSSLRETDRGVSAEYCFPVWRSSHTVKWEGVWRELGCLSRTASFAVRKESGHSLKSSLSHAMVLDSRNSSILPRRGALLKVNQELAGYTGGDVSFIKEDFELQLNKQLIFDSVFSASLWGGMLVPIGDKPSSIADRFYLGGPTSVRGFSMHSVGPQSEGDYLGGEAYWAGGLHLYTPLPFRPGQGGFGELFRTHFFLNAGNLCNLNYGEGPKAHIRKLAECIRWSYGAGIVLRLGNIARLELNYCIPMGVQGGDR
The following text describes a protein:
Function:
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MDKIIKTISESGAFRAFVLDSTETVRTAQEKHQTQASSTVALGRTLIASQILAANEKGNTKLTVKVLGSSSLGAIITVADTKGNVKGYVQNPGVDIKKTATGEVLVGPFVGNGQFLVITDYGTGNPYNSITPLISGEIGEDLAFYLTESQQTPSAVGLNVLLDEEDKVKVAGGFLVQVLPGAKKEEIARFEKRIQEMPAISTLLESDDHIEALLKAIYGDEAYKRLSEEEIRFQCDCSHERFMNALASLPSSDLQEMKEEDHGAEITCQFCQTTYNFDEKDLEELIRDKS
The following text describes a protein:
Function:
Sodium-phosphate symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIHPYLWIAVVGGFVGFLVACGNGANDLANAFGTSYGSRVLTMLQIVVIAAVCEFSGAVGLGSEVATTMSSGIAKLSTFEDDPYVLMYGFLCTLGATFIWLLVATLANLPVSSHHAVAGGIIGFALVYGGGDAVVWAGRKQAFPYVSGFVPIVISWFVSPLLAGLAAAVLYSMARFLLLERTFAVRLAPYLMPVVVLIVFFLEFIFIFLNAARNRLSWSSGHAAWMAIAVAASVAVLSLGLVPVMKRRIESIRVSGEKCGAEEGCDAVEAMRMKMTGARASSIRTFKTRRQAGEHLMAEKQRRKARKTPANLVKTEPIEEGSNEAEDARAAKKLGLASRLVYGAVVRDESSDVDSPLDENVNGAQGSSDEVDVAHETAIDPKFNYLKYDESGVRMFDPRAEYMFRMLQVVTAACTSLAHGSNDVSNAIGPYAAIYQVYRTGNVASAANVEVWLLCLGGAGIVVGLATFGLPIMRLLGEKLAVLTPVRGCAAEVATALVVSLASSYGIPVSSTHCITGAVLAISMVDIGFRRVCWALVLKMYVGWVFTLIVTAIISACFFAQGIAAPVPRGSR
The following text describes a protein:
Function:
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
Subcellular Localization:
Cytoplasm.
Sequence:
MRFYIKTFGCQMNENDSEAMAGLLVKEGFTPASSPEEADVVIINTCAVRRKSEEKAYSELGQVLKLKKKKKIVVGVAGCVAEKEREKFLEKGADFVLGTRAVPRVTEAVKKALEGEKVALFEDHLDEYTHELPRIRTSRHHAWVTIIHGCDRFCTYCIVPYTRGRERSRPMADILEEVKKLAEQGYREVTFLGQNVDAYGKDLKDGSSLAKLLEEASKIEGIERIWFLTSYPTDFSDELIEVIAKNPKVAKSVHLPVQSGSNRILKLMNRRYTKEEYLALLEKIRSKVPEVAISSDIIVGFPTETEEDFMETVDLVEKAQFERLNLAIYSPREGTVAWKYYKDDVPYEEKVRRMQFLMNLQKRINRKLNERYRGKTVRIIVEAQAKNGLFYGRDIRNKIIAFEGEDWMIGRFADVKVEKITAGPLYGKVVWVEKTPSPVSSSE
The following text describes a protein:
Function:
Orphan receptor; could be a chemoattractant receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDKTKPMKYISVKEMNTSNNSEDEVSINIALGSFILVSFLVGMAINGTILWLLWMKMTRTVNTLWFLHLTLSYLISCCTLPFFGISNVLNLRWIFKDAMCKLSVFFITLGMVSTVFLLATISLDRYLLICHPVWSQHNRTIPRAWRLIIGAWLLSVCISAPYLAFSKTREVENYGSICTVNYTVYEKWDGDKIELAFIVVRFLLNFLLPFFTIMFCYCSMGWKMKKKRLVRTGKPFKVLGVAVASFFIFRLPFYLYMCFLLIHKETSLRETQEHLRIIFHIGVCLNICFTPFIYLFVGEKFQQVFKTSIVVLLKKSFTESPSMLLETASLRTEDMRTSNNSSSNNLEMVTIHGKDRPLL
The following text describes a protein:
Function:
Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA.
Sequence:
MGCDGGTIPKRHELVKGPKKVEKVVIKSLVSRASLLASYPSSFVCLLSDLGHAASPLGASVSSTTKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKSSEKALGKAASHIKSIKNVTELRLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALREIKAEVCHTCGAAFQEDDVIVLNGTKEDVAMLKSRMEERRLKAKLGKKAKKPKAAESVSKPDVSEESPGTSKIKTGKPEEAGLDSREKKTNSAPKSAATNGSSSGKVGKPPCGAMKRSIADSEESEAYKSLFTTHSSAKRSKEESAHWVTHTSYCF
The following text describes a protein:
Function:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Subcellular Localization:
Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
Sequence:
MANASATPKTPRRRRRVTFLARTCHRLLRLLATHRLRRGGHGLNSISAGDDSPPSGQPPRGRDAEEAEATQAAAAAQRRHEERHGDDDAAATEEAEAAVAGKYWAQRRSLFSLYDRGVRMDAEGWYSATPEPIAAAQAARAPPGSLVLDAFAGVGGNSIQFAARGCYVVAVEIDPRKVELAAHNARIYGVDDMIEFVVADFFHLAPSLKADLVFLSPPWGGPSYSQAQVYSLDMLKPRDGFTIFQAAQEISPNIIMFLPRNVDLSQVEQLSWLSSPPLDFVSEENYIEHRFKGITAYFGGLAQEVLKQG
The following text describes a protein:
Function:
Metal transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAPVGGGGRPGGGPARGRLLLAAPVLLVLLWALGARGQGSPQQGTIVGMRLASCNKSCGTNPDGIIFVSEGSTVNLRLYGYSLGNISSNLISFTEVDDAETLHKSTSCLELTKDLVVQQLVNVSRGNTSGVLVVLTKFLRRSESMKLYALCTRAQPDGPWLKWTDKDSLLFMVEEPGRFLPLWLHILLITVLLVLSGIFSGLNLGLMALDPMELRIVQNCGTEKERRYARKIEPIRRKGNYLLCSLLLGNVLVNTSLTILLDNLIGSGLMAVASSTIGIVIFGEILPQALCSRHGLAVGANTILLTKFFMLLTFPLSFPISKLLDFFLGQEIRTVYNREKLMEMLKVTEPYNDLVKEELNMIQGALELRTKTVEDIMTQLQDCFMIRSDAILDFNTMSEIMESGYTRIPVFEDEQSNIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVFHDTKLDAMLEEFKKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDMYTDNRSRKRVSEKNKRDFSAFKDADNELKVKISPQLLLAAHRFLATEVSQFSPSLISEKILLRLLKYPDVIQELKFDEHNKYYARHYLYTRNKPADYFILILQGKVEVEAGKENMKFETGAFSYYGTMALTSVPSDRSPAHPTPLSRSASLSYPDRTDVSTAATLAGSSNQFGSSVLGQYISDFSVRALVDLQYIKITRQQYQNGLLASRMENSPQFPIDGCTTHMENLAEKSELPVVDETTTLLNERNSLLHKASHENAI
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication; Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.
Subcellular Localization:
Nucleus.
Sequence:
MNKLPKGWNFTIVDDNADSTNSENIQGKRPRRSRTSVQRSDGASPIIRDNIVLIRTDDNEEFKVGDTIEITQGKGPEDPTTEYGLITEIKFGNSEFIEVIVDWFIRSSEIVGMPNDFFADNELLLTPFRSEVKFIDFIRPINVLSESQFADVVIDESNSHSTFLVKRATDNEGNFSDIFDYKDFSGKVLENPKKCAIQVKELISTTVQKELLKEFSKEQRKKKANKVSTTGRVTRFNKRKESVSTKAIKPENKQVRIEIDNDVLSDQSEEKQEESDYNEAEDANSALESDEENISQESEDSEVEYSTKKKLKNKKLSRRSKAAATPSPKRKLQKKDIEDIYSVVTPTKRMKLGKDDRDSLPVFLSPTKSVPSEFTDPKSVAFKEVKQRLHTSQKLNALPGREDEFAMIYMNLESAVNEKTGCCVYVCGVPGMGKTATIKDVVEQMTYSSERGEMEQFSYLELNGLKLLSPTVAYEALWHHISGDKVSASNAALLLEEYFKREDHKRKPLVILMDEFDQIATKKQNVMYNFFNWPTYSTSKLIVIAVANTMDLPERMLTNKIASRLGLRRIQFRGYTFQQLGDIITHRLEMITKNNRRKVVITSDAIGFASRKVASVSGDARRALTICRRAVEIAEKEYLENKKGEDDSGPYQVLISHISTAINETVNSPLSKYIASLPFASKLVLASLLRRSRRTGLAENSLGDIIDEMRNSFAMATHSEEQGSDELNMQDVLYSDKTFTATNETAPILNLRIHFFKQIVTSLVEAGIIIQQNSPGERSRLVKLDVPEEEVVSVFKKDNAISQFL
The following text describes a protein:
Function:
Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance. Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex to regulate dendritic spine distribution of the STRIPAK complex in hippocampal neurons.
Subcellular Localization:
Cell projection, dendritic spine. Cytoplasm, cell cortex.
Sequence:
MASDGAKGEQPPPLQTLVTTGHGSVEAKCELNIDNLSKPELLTLLSIMEGELEARDLVIEALRARRKEVFLQERYGQFSLTDPFLAMQRDFESGMGPKDRRPVSASPITVLEAVMAHCRKMQEKMSAQLSAAETRQKRLEMEKLQLQSLEQEHRKLSAQLKDEREKNKHVVMSLVHECKQLAARVVEENQRFEELSSRTEQDGRSVGRLEEELASERRRSQQMEAEMEKQLAEFDTEREQLRARLSREETRAVELRAESENLRLQVEQLRTERCKDSPPLPSVTPASVSVKPKAMVSVAVGTEATVCKTVSSQTDAPLENEGAKKVPLSIPVKPSGSTYASMNLPKTSSAGRGLHHGSSQAENGGDGQTHLHSSHSPGVSSTLPTGVSPRVQAARYKFQPSASEQDQNGTANQSPPSRDLSPTNRDNFAAKQQARHTVTQVLSRFTSPPAGGPPAALRPGLPHSTSEGGPFTGRLGHPQIGLKSPTVARIDRGNPPPIPPKKPGLSQTPSPPHPPIKVVGEASRSPGTGLGVGLAKSATTPQLPPKPSLDMGGTVPAMTASQVGASCSGWPWGQQPTAACVECPPVITSSTATIVSSPSINPSSLPSHSPQHLGSPLAAASGWCPSIVPSLTCGDPVPLDDGQTLLLQAASQGNVTLLSMLLNQDPLLDIHHHQHELTSALISAAHNGHTDCLNLLLTSGASADAADETGFSPLHAAMQNGHHGCARALVNCGADLEKEYSQGRTPLYLACEQGHVQCVKVLLDAGADRTHVTTDSCTALHAAVSSGHVDTLKLLLHHPSSEPDHLNSPTFPSDAKQELQKPGISKACHILNHSNQDGWTAAHIAASRGYKKCLEVLCNHSQHDMERRDKCNRTIHDVATDDCKDLLENLDWYTVVVQVLMGSPERLCPVDLLEDGCTVGKVTVQRHTSWEELTESLSHLLTNHLQLICGSWELQDVLARADTLGLSANSIASVIIGDAVWMAGQDLAQSPWDLVRKRLSQRITIRLKGLSECALDEMTYDSLISVQLLQNYVRLVEQYHNVIFHGLEGSFQEYIANQISHYIKHRQEAQGIICDVIRVEIEENLSKEQLLEIFINCGFLVSLHESSAGHCVVVVLEGLERAHSLSHILGDLCEALENRGSVYSLSLNHGHDGLYYFREGSFLMGTLAKPRLQGAELRLQQHFRWVQLRWDSEPLNGMLGRHMRRKLLHKTQGQCWTSDDPLQKALSWVCSVWHQLNACLSRLGTSEALLGPYIFLSCPVNLEQTQAIPKWLVRLWNAVIVPRVEDAVISRVTAKRSPSQRRSPNSKALTPGQRAVVKAALNILLNKAVLQGCPLPRPEIDRLLPELQGGCFPLSAIGSAYRKGGRKGAWRRANTSPRKKGSPASGRSSSCSFREGSLANSSTQSMTNGNHASGLSLCSDDETDLIRELQSMCSSKSEPDISKIALFKEDFIMLPHSSSASPQGTDGEVNQPQTHSHTADRAVDNTRPPAQQTDSVHTSPRRVMRPRSHLPVPSSRGSQQMISSSSSLQTHSRASTSSSRTRQPPSNNNTNNLSQDHIWFLDPNSNENYSTHG