The following text describes a protein:
Function:
A cell wall protein involved with Hsa in host cell interactions required for colonization and pathogenesis. Involved in recognition of platelets. Interacts with human platelet integrin receptor GPIIbIIIa (a complex of ITGA2B and ITGB3). Involved in platelet spreading, presumably by activation of outside-in signaling leading to platelet activation and then spreading. Spreading also involves GPIIbIIIa. Binding to platelets under static conditions causes platelet dense granules to secrete ADP (similar to release induced by fibrinogen binding), has no effect on platelet alpha granule release. The N-terminal 656 aa residue fragment (called F2) also binds platelets, causes dense granule secretion and allows platelet spreading. Acts in concert with Hsa to promote binding to human fibronectin (FN1) and vitronectin (VTN), and biofilm formation. F2 bind activated platelets more strongly than unactivated platelets. Binding to both FN1 and VTN is mediated at least in part by their glycosylation.
Miscellaneous:
MISCELLANEOUS: S.gordonii, a commensal oral cavity bacteria, is among the bacteria most frequently identified as being the primary etiological agents of subacute infective endocarditis (found in 13% of cases).
Subcellular Localization:
Secreted, cell wall; Peptidoglycan-anchor.
Domain:
The central region (709-3205) contains 17 RrgB repeats and may serve as a flexible extension that holds the N-terminus away from the bacterial surface (Probable). Immobilized protein fragments 34-690 (also called F2) and 34-1328 bind to human platelets but 34-359 does not. Three integrin-like recognition motifs (NGR, RGT and AGD) are involved together in platelet recognition, but not in fibronectin- or vitronectin-binding, nor biofilm formation.
Sequence:
MKDFLKKVLILFTVLLMSMPSSVLNLGTSVVRADDPLNIETRRIDEHTTITQNGCYRKIEKTDATDWTVPRKPIDLVILQDASGSFRTTIPSVKNALKRLTTYVSPEQYDENDPHLVKTDDPRTTDRVFVASYQGLDQVRYFENNDFSGNPANVYTDANSTGKNYTYGNSGLTSDQNKVHNFIDNIAVDGGTPTVPAIDDTIAQYNRVKGNMENGRKTVFLLVTDGVANGYRLPGTNTVVMDKSWTRTDAIQKAWRVDSYPEAAQDIIGRANELKAAGNQLKAAVGSEGSVVVGFWERVDNFTEKYYQYGPAYLNGFGNTINIGDNRSVQAIFHDALQSMASPDKVVNGKNVSFYVNEQNNIDVFSQKILESVAAALVKDDITGEFDITEGYKVDAIRINGKKIVPKVTDPSKEIRGTITQTGNKVKISVPDSVFNPGKNSFDYDLSKEARAPETDEDSEVDPPENYVPEKEEITVPELTGKFKAGDFETRQIGGRNQTVEVQKLEYCYPSATKTVKDADASNDIGVIPDPLELTKKPSYSAQLSKKDEEFTYTVDYNFNNVPYEFEKNVMLTDPIDYRLEVVSHSAQGPDGQSWPTRVVTQQDAGGNSQSVVVADVPPQGKDYNYLIMKKAKLKMTVRLKEEYRKNQASKAYLAILQNNNGYGLVNQGNIMWNGEDDSPNQDAHAKTKDKASTIRRSNPIYVKPPLDTEVDKKVNEKEHEGLQADGEEFEYKVTAPWPGIADKFTLTDTVVDELEIVPNSAKVTVAGKSYNALTKAISINGQTIDITLDKAQLTSLNRLISRRGGSEVQEIELIFKAKIRPGADLSKYKKNGAVNIPNTADVILNDKKKTSKEVTVTPPKPKEPTVSKKINNTLDSLVTFDGQPYTYNITTAVPSDVAGYKKFVISDKLDADLEFDGQASISGPLADVFEIQTNGQTVTATVKEGKFKELAKYSFVELTIPAKVKAGVTGKTIENKAKISFTNENNVAKEVESNPVTVTPPPVTKKINENLDHLDIATGQPYKYNVKTTLPSDITSYKEFVITDTLEDELSVINEGTDKPVISGPAAEFFDVTVSGQKVTATMKNFAGASALAGQEIELVIPAKINDGVTRSNIPNKATFSFKDKNDHKGEKETIPVTVTPPTEPNVSKKINGDQDNATIAAETDFTYNIKTTLPNDIDTYKSFAITDTLDENLGVVNPEPSISEEAKKFFDITVSGNTVTATMKDFAKASALANKEIELVIHAKVKKESVLPEIPNTAKITYTNKNNESKEKETEPVKVTPPPITKKVNGKDQEDLASLTSTFKYTVDSKVPIVADKFVLSDTLEEVLTFDGDATVTIDGQTVTDVTVAKKDQKLTVTFDKDQVKKYAGKAVQVAFDAKIKSGYTVDQLVAKYPNGDKAAIPNKASFVVNDNPETEKFSNPVTVTPPPPNTPEIEKKVNGADSYNLQTRLEEFTYSLNTAMPTNATEFTVTDELKSVLEFAGKKGDVQVKIDGKAANDQATISTDKNTLTVAFAEKAVKANAGKSIEVTFKAKIREGANLLDYLVPGQGIRIPNKASYDIDHNPKFHKDSNEVPVTPPSPEQPPIEKDVNDKAEATLEARDEEFTYHVKTKIPYEATAFNITDTLKEVLDFSGEKGQAEATVDGKKLSDDHIAINGQTITVTLNQEELKANADKEIKLTFKAKIRPNANLAAYVVGDKVVINNQASYNVDLPDNPGVHKDSNIVPVTPPSPEKPEIEKTVNDAKEATLANRDEIFTYKVKTKVPFDATAFSIDDTIKDVLEFADAGSATLNGEALEADRISIADQKITLTLTEDQVKNNGGKEVVLTFKAKIRQGANLSGYIEKGKTVINNQASYNAAFPNDPNFHKDSNIVPVTPPNPENPPIEKKVNEAESANLGARDEEFTYTIDTTVPLDVTGFAVYDTIEKVLEFSGENGQASATVDGQPLDASHITIKGQKITVKLTEDEAKALGGKAVHVSFKAKIKAGANLSDYIEKDGTTRIYNTAKYNFNNDPGTEQSSKPVPVIPPTPTEPELKKEVNGKEAETLANRDDVFTYTVKTTVPQDATAFSISDSLVPVLEFAGEDAEASLTLNGEKLDAKQIKLKDQTISAELTEAQVKANGGKEVVLNFKAKIREGANLADYIEADGVTRVPNKASYVANFPHRPKVEKDSNIVPVTPPSPENPPVEKKVNNKPSATLDSRDEEFTYTIDTKVPVDATGFKITDELKDVLEFSGKKGQAEVTVDGDKDVIEDSQITVDKQVLTVTLTKDQVKKYGNKAVHVSFKAKIRKNVSLAGYIEADGVTRIPNIAKYIINDDPKTEKSTEPVPVIPPSPEEPGIKKEVNGQPEATLKERYEEFTYKVTTSVPQDATAFSVSDTLVPVLEFSGEKGQATATLDGQEIDANRINVADQTISMALTEDEVKANGGKEVTLTFKAKIREGANLSAYIEKGKTSIPNTASYTAGFPNRPEIHKDSNRVPVTPPTPEEPEIKKDVNGKEEETLANRNDEFTYHINTKVPFDATAFSINDELKDVLEFADGTGRATASLNGQALDADRISINGQTITVNLTEEQVKNNGGKDVNLTFTAKIRQGVNLSGYIKDGKTSIPNKASYRVDFPNNPGVTKDSNEVPVTPPSPENPPIEKKVNEAESANLGARDEEFTYTIDTTVPLDVTGFAVYDTIEKVLEFSGENGQASATVDGQPLDASHITIKGQKITVKLTEDEAKALGGKAVHVSFKAKIKAGANLSDYIEKDGTTRIYNTAKYNFNNDPGTEQSSKPVPVIPPTPTEPELKKEVNGKEAETLANRDDVFTYTVKTTVPQDATAFSISDKLEDVLEFAGESSATLAGEDLKADQITTDGQIIKLTLTEDQVKANGGKEVVLNFKAKIREGANLSAYMKADKAEVPNKASYTVGFPNKPAVTKDSNEVPVTPPSPEQPPIEKDVNSKPSETIADRTEEFTYNIHTTMPQDATGFTVTDELKDVLEFAGDVQVTLGGKKADAAVAKNGQTLEVTFPEETVKANGGKKVQVTFKAKIKADADLTPYETANSYSVPNTASYLINNNPTSKKETKPVTVEVPKQPGPEVTKKINRTLDHLDVDRDVPYMYNVNTQIPKDIRLYKEFTVTDTLEPVLEITGTPVAYVDGYATDAVETKVEGNTVTVTVKDFARISGYKEIQLYIPAKLKADSDLSAYENQTVPNKATIAFKDSNGKNGTKESNPVTVRPRDPEKPEEPKPNEPAKTVGPADGSNPSTAYRLKELKEGFRFDVTAKVPTDPVDESGNPIKDAQGRDVKTELNSFTVTDELEKVLKVDRVAVKVEENKVAEAIAKITAKIEKAESDLKELEGKETNGTFAKKLAEAEKKVEELTAQLAAAKEKAAAAPATPAPASDSDAGNATATPAPADNNAEVAALEESLKAAQAELEQLKADGAKAGNLATPEEQKVEQDKLNKNLEQLKESKEKLEKALEAFTTVNDKGEITDEALAKIAKVTVEGQKVTVEVTDKAVLEALKGSTFRVIIYSSIKDGADLSSYLNKENNETKIPNKATVTFNDKPKVTNTVNVYPPEPTTPPQTPPHTPPTTPGTPPPTTPDTPPAPKGDLPPAPTPEPEKPKNILPKTGTSATMVNEVIIGMILVLMGLLLRRKPKH