lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA with a specific cleavage site in the 5' overhang strand exactly one nucleotide 3' of the branch point. Structure- and sequence-specific nuclease that resolves holliday junctions (HJs) by symmetrically oriented incisions in two opposing strands near the junction point, thus leading to ligatable products; HJs are physical links between homologous DNA molecules that arise as central intermediary structures during homologous recombination and repair in meiotic and somatic cells. Structure-specific nuclease with 5'-flap endonuclease activity, preferentially cleaving static flaps 5' overhang strand exactly one nucleotide in the 3' direction of the branch point. Also able to cleave double-stranded flap strand 1 exactly at the branch point.
Subcellular Localization:
Nucleus.
Sequence:
MGVGGNFWDLLRPYAQQQGFDFLRNKRVAVDLSFWIVQHETAVKGFVLKPHLRLTFFRTINLFSKFGAYPVFVVDGTPSPLKSQARISRFFRSSGIDTCNLPVIKDGVSVERNKLFSEWVRECVELLELLGIPVLKANGEAEALCAQLNSQGFVDACITPDSDAFLFGAMCVIKDIKPNSREPFECYHMSHIESGLGLKRKHLIAISLLVGNDYDSGGVLGIGVDKALRIVREFSEDQVLERLQDIGNGLQPAVPGGIKSGDDGEEFRSEMKKRSPHCSRCGHLGSKRTHFKSSCEHCGCDSGCIKKPLGFRCECSFCSKDRDLREQKKTNDWWIKVCDKIALAPEFPNRKIIELYLSDGLMTGDGSSMSWGTPDTGMLVDLMVFKLHWDPSYVRKMLLPMLSTIYLREKARNNTGYALLCDQYEFHSIKCIKTRYGHQSFVIRWRKPKSTSGYSHSHSEPEESIVVLEEEEESVDPLDGLNEPQVQNDNGDCFLLTDECIGLVQSAFPDETEHFLHEKKLRESKKKNVSEEETATPRATTMGVQRSITDFYRSAKKAAAGQSIETGGSSKASAEKKRQATSTSSSNLTKSVRRRLLFG
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MECPTNLEDDTLEIAVGSDQLAFRDPDAGDEILATLSAPSASPSPLFYPTSVAFVISAKSVPESRTVISDSRSESFASSKQKVSDPPVRNEGPLEDLGRPLRSKAVDKWLNVVLDPNGILCVCEDWKSNRSTKQYSNSSVPHSATIGTIVGMKAVYVRPNCLNFLAELGKIARISVWSSMKSSNIQGIVNYLFLKEMLPGLVLRQDSCTTIRFRDSSG
The following text describes a protein:
Function:
Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC. May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade. May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.
Miscellaneous:
MISCELLANEOUS: Was named CHICA (girl in Spanish) because it interacts with KID.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Primarily cytoplasmic during interphase, but at prophase, associates with spindle microtubules, with a clear concentration toward the spindle poles. It persists on spindle microtubules through metaphase and anaphase.
Domain:
All members of the FAM83 family of proteins share a conserved N-terminal DUF1669 (domain of unknown function 1669) domain of about 300 amino acids. This domain mediates the interaction with casein kinase 1 (CK1) isoforms. Therefore, it has been proposed to rename DUF1669 the polypeptide anchor of CK1 domain.
Sequence:
MALLSEGLDEVPAACLSPCGPPNPTELFSESRRLALEELVAGGPEAFAAFLRRERLARFLNPDEVHAILRAAERPGEEGAAAAAAAEDSFGSSHDCSSGTYFPEQSDLEPPLLELGWPAFYQGAYRGATRVETHFQPRGAGEGGPYGCKDALRQQLRSAREVIAVVMDVFTDIDIFRDLQEICRKQGVAVYILLDQALLSQFLDMCMDLKVHPEQEKLMTVRTITGNIYYARSGTKIIGKVHEKFTLIDGIRVATGSYSFTWTDGKLNSSNLVILSGQVVEHFDLEFRILYAQSKPISPKLLSHFQSSNKFDHLTNRKPQSKELTLGNLLRMRLARLSSTPRKADLDPEMPAEGKAERKPHDCESSTVSEEDYFSSHRDELQSRKAIDAATQTEPGEEMPGLSVSEVGTQTSITTACAGTQTAVITRIASSQTTIWSRSTTTQTDMDENILFPRGTQSTEGSPVSKMSVSRSSSLKSSSSVSSQGSVASSTGSPASIRTTDFHNPGYPKYLGTPHLELYLSDSLRNLNKERQFHFAGIRSRLNHMLAMLSRRTLFTENHLGLHSGNFSRVNLLAVRDVALYPSYQ
The following text describes a protein:
Function:
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Miscellaneous:
MISCELLANEOUS: The porphobilinogen subunits are added to the dipyrromethane group.
Sequence:
MIRIGTRGSKLALYQANKVAELLKNLGYKVEIKIIKTTGDRVLDKKLSDIGIGVFTKELDLAMLNNEIDIAVHSLKDIPTIWNENLMVGAVLERDSYHDLLIWNKDIDFNEDSKIVIGTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIVLSEAGIIRLGVSLEDFNYKRLDILPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVPFGALAVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN
The following text describes a protein:
Function:
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MFHTGDLNSGINKALAESKLVACFVTNGNEESRLWEDEFLQDSELSSQLQERSVLLRLDFGSEEANYLAAIFPIPKAPTLVAIWSGELKEYLAAGTTKQEFLVRLGKALESAHSRRNVENDRPSYSQTSEYRTTNIQNQQSSDHPSTGDFDDGSTVPFQSTSNNTSSSSSLPIDPRGNPPKGTKSNVEDQPKQPSQAEDTANYAAIQRKRHQEAREERARILALVESDKVRRRKDAERKANRNNELTAKSAAFGGTSSSVPASAPKAQDCALQIRLFDGSSIRSKFPNTSTLNGDVRKWIDDHQNDDVPYIFKHVCTPLPNKTLSMTDESRDLAALGLSPSATLIIVPVQAYTSAYETTEPRGILSRGIAAGYSLGTWGINRVLTTIGGIVGSPAVAPGIDERIEASAPVGGSRPSNLRTLRDQNDNDAHHELYNGNTLNFEPRKDDHDGDD
The following text describes a protein:
Function:
Modulates the polysaccharide chain length of enterobacterial common antigen (ECA).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTQPLPGARAVSAENELDIRGLFRTLWAGKFWIIGIGLLFALIALAYTFFARQEWSATAITDRPTVNMLGGYYSQQQFLRNLDIKTDPASSDKPSVMDEAYKEFIMQLASWDTRRDFWLQTDYYKQRMVGNSKADAAMLDELINNIQFTPGDFTRAINDNVKLIAETAPDANNLLRQYVAFASQRAASHLNDELKGAWAARTVQMKAQVKRQEEVAKAIYSRRVNSIEQALKIAEQHNISRSATDVPADELPDSELFLLGRPMLQARLENLQAVGPAFDLDYFQNRAMLNTLNVGPTLDPRFQTYRYLRTPEEPVKRDSPRRAFLMIMWGIVGALIGAGVALTRRRTI
The following text describes a protein:
Function:
Involved in mitochondrial migration along actin filaments.
Miscellaneous:
MISCELLANEOUS: Present with 450 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, actin patch. Note=Cortical actin patches. Localizes at the shmoo tip.
Sequence:
MPSEVTPKVPERPSRRKTSELFPLSGSESGDIKANSEPPTPAGTPNVPTRRPILKAKTMTSFESGMDQESLPKVPLQRPVRRSTTEELNNVMNNTSKELEEIESLISKHNIHNVSRKKSPTSVEEGKVAAIHQNGQRSASDNKTSTNPSPLEKNEHEGAEGNESAISPSNLVNKSNNEVTEHSDSEDLTEKQKVHAALDNEAGDRSHFEEKLIPGDMKVQVDVSKDVEEGSLNALPPSGITESDDKAEKFTKHPESSLEELQKHQEQQEEKIFQNPTDEESTTSLNEKQEGKDNMEVNSQPQGPSDTETVIAATSSNVPSQIASEEENDVPVIPRSRPKKDFEAHVQKEELPNTQEKRVSEECDSTLISTEEESKIPKIPSERPKRRAPPPVPKKPSSRIAAFQEMLQKQQQQDLHNNGNSSATTASADIAKKHTDSSITSDTTKADFTSKLNGLFALPGMVNPGQLPPSLEKKLSSPDTESKLGPQDQSQAKTGPLGGTRRGRGPRGRKLPSKVASVEKIEEDDNTNKIEIFNNWNVSSSFSKEKVLIDTTPGEQAERALDEKSKSIPEEQREQSPNKMEAALCPFELDEKEKLPANAESDPLSQLPQTNAVGNRKAISEESLSPSEAIANRDQNDTTEIQEQQMEDQMEVDMERELSGGYEDVDSALHSEEASFHSL
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGEDFPGQKRQQDIFQYCVVCSFAMALTCGWAFRSVRIGCYAYLVGLVLTWLVNIVEWDYFFSPASSWNEGKYLDVTGYWELEARDRMSVNQLKDRVPKQRSQITMSGGPARMTISSRPMPEFRFKKWVPNPCLPKTLFS
The following text describes a protein:
Function:
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MDVAVGRGFQVVAFSGSSFHGKSIRKASAAVSGINWTARTGHSPRPCTTVVQAQQRPTWLPGLDPPPHLDGTLAGDFGFDPLGLGEDPESLRWYVQAELVHARFAMAGVAGILLTDLLRVTGIRDLPVWFVETKRFMDFLNPGSQAKPGSFFGLEAALEGLEPGYPGGPLLNPLGIAKDIKNAKDWKQKEIKNGRLAMVAMLGIFVQASVTHVGPIDNLIEHLSNPWHKTILQAIAASSS
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGSKRTSRKAAPVPAKGGEPAQADEADAAPEVEAESPIIISKWDGQTVRNSLEEAFCKATGDAVPEEFEQATAEEDFKLIMAAIGCAFAGYACIYGLFVPHPASSQVVGICAAAYFVFMTILNVHAMFFDQHAAVLMRSQKTGQRLSTFVHMNKYSPELTVEMILASSAGTSSSQTFDGHVGQFFYEDGEMCREAVVQVTEDLLSQLLALKNE
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MATTEGTTESIDSITFSFLTDEEVRNHSFVKISNPRLLDLVERPIPGGLYDPALGPLSERTTCKVCGQRSTNCPGHCGHIDLISPVYNPLLFGFLHKLLQRTCFFCYHFRVQRGQVEKCVKQLELIVKGDIVGAKRLDSVSLNEALYPEETDGSSESCSTIHSGAQHHNVEHMKQQGWTSLQLSEAMSVFNSFLKPKFKKCKNCERANPNITKPTFGWFHTSGMSDASIRANVIRAKKLGGPLNGESEGVMDVEDPAAPPENQDTSRKRHKQKGGQEVLEFIKQKSVFSRQLLPTEVKDVLELLWENEARLCSFITDLQQQGFEKKKAGPSMFFLETILVPPIKFRPPTKGGDSVMEHPQTVLLSKILQSNISLGDAHINKEHSKVVRRWMELQQSINMLFDSKTAKGTGQRDVASGICQLLEKKEGLFRQKMMGKRVNYACRSVISPDPYLGVNEIGIPPCFAVKLTYPERVTPWNIAKLRNAVINGSESHPGATHYVDKLSINKLPPARKARISISRKLPSSRGAVTEPGKSSDCGYEGKIVYRHLQDGDVVLVNRQPTLHKPSIMAHVVRVLKGEKTLRMHYANCSTYNADFDGDEMNVHFPQDEVSRAEAYNIVNANNQYVRPSNGEPLRALIQDHIISSVLLTKKDTFLRQDEFTQLLYSTGVSTSAPTTFHGRPGQKVLWSQSEDEIDTIQPAIWKPEPLWTGKQVITAVLNHITKGHPPFTVEKDAKIPYNFFKSRANDYKPCKEKKSGGRGKKSGEDKDHKSVGDTLEKKELGEEKLFIYRNELVRGVIDKAQFGEYGLVHTVHELFGSNTAGILLSVLSRLFTAYLQMHGFTCGVDDLLILKAQDNERKKQLESCEKSGELVHRNFIGIEDENLNIDPVELQLKIENTIRSRDEDSGLSYLDRLMSNELNTKTSSGVIDKLLSDGLVKPSVKNCISLMTTSGAKGSKVNFQQISSFLGQQELEGKRVPRMVSGKTLPCFPPWDWAARAGGYIIDRFLTGLRPQEYYFHCMAGREGLVDTAVKTSRSGYLQRCLIKNLECLKIGYDHTVRDADGSVIQFFYGEDGVDVHQTGFIAKFKELALNQDMIHKRCGGQLGTFNTYISGLPIALKDKADKFFDDFPLIGRVASNLVKREDLYNLIKQKFLLSLAQPGEPVGVLAAQSVGEPSTQMTLNTFHLAGRGEMNVTLGIPRLQEILMTASSDIKTPIMTCPLQMGQTKESAEYLADKLKKITVAEVIESMEVSLLPLATQDSDCCRIYKLEMKLYIPAHYPKYANMSVEDWEETLEVAFVRELEDAIQNHMLLLSRISGIKNFLPDSQSRASNEADEDGSGERSHKAENDDDDEEEDDGEKAEDLGLDAEKRKVRATDEMDYDDGFEDHLNEVESIASEESSGFESEIDQGDNEIDIRKDAVLDNEASESPLQGKPSKPKSKIVAPETPSRGESHSEPKSRDKKKKQKAKRSKGPKLVKKDYDRAIYVETRNMHFEVHFKFTNEPHILLAEIAKNSAKKVYIQNPGKIEQCRVTDCKENQVIYYGENPKERVDIEPKEKEKFPALHVTGVDFNAFWQLQDHLDVRYLYSNNIHAMLRTYGVEAARETLIREINHVFKSYGISVSTRHLSLIADFMTHSGGYRSMSRLGGIAESVSPFSKMSFETASKFIVEAALHGETDELETPSARICLGLPVKMGTGSFDLMQKLEI
The following text describes a protein:
Function:
Rhamnosyltransferase involved in lipopolysaccharide biosynthesis.
Sequence:
MVYIIIVSHGHEDYIKKLLENLNADDEHYKIIVRDNKDSLLLKQICQHYAGLDYISGGVYGFGHNNNIAVAYVKEKYRPADDDYILFLNPDIIMKHDDLLTYIKYVESKRYAFSTLCLFRDEAKSLHDYSVRKFPVLSDFIVSFMLGINKTKIPKESIYSDTVVDWCAGSFMLVRFSDFVRVNGFDQGYFMYCEDIDLCLRLSLAGVRLHYVPAFHAIHYAHHDNRSFFSKAFRWHLKSTFRYLARKRILSNRNFDRISSVFHP
The following text describes a protein:
Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Sequence:
MNAAPMEPHRRRLLFAARSPPPAVVKALFPAGPRSPVTGLAVTMDRLGGLGRLLGCSPALKSHLDPLDCDVFQQGDENKENEAFEFKKPARPAARGCLLAQGPGEGKDAFAQRQNSAPARMFSPGDKDAGDLSDFIPVFLPQSPLPSSLADEDDGFLDLLDGDDLKNDEESPSGMASLWTAPLVMRRMSNYVSLPVGLEGGGGAEILLSVSHPFRSVPGSPGPARTPPPASEAIESMLDGDHRDLIGDFSKVYLFHTVAGKHQDLKYISPEIMASVLNGKFASLIEECVIIDCRYPYEYEGGHIKGAVNLHMEEEVESFLLKKPILPAHGKRVIVVFHCEFSSERGPRMCRFVRKRDRLGNEYPKLHYPELYVLKGGYKDFFSKCQSFCEPPGYRPMHHEDFKEDLKRFRTKSRTWAGEKSKREMYSRLKKL
The following text describes a protein:
Function:
This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
Sequence:
MSRGRFSYSFQNFDPERMARASGRDLRISPKHSVELLREIRGMMLNDALRYLDDVIAKKRPVPMKRFNDSQGHKPGKGFGPGRYPVKVAKAVKKILLNAKNNAEQKGLDVDRLKIIHAAAHRGPVLRGYIPRAFGRATPFNEQTTHIEIVVEEIRR
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MLSLLLILPVIGALIIGFFPGNIPAKQLRQITEVFAVLTLVWSLLVLFKFDVTDPQFQFQEYLPWIPQLGLNYSLAIDGLSLPLVILNNLLTGVAIYSIGPNVNRSRLYYGLILLINAGISGALLAQNLLLFIVFYELELIPFYLMIAIWGGEKRGYASMKFLLYTAFSGLLVLAAFLGMSLLSGSHSFDYNPEITQTFTESAQTILLILILLGFGIKIPLVPLHTWLPDAYTEASPATAILLGGILAKLGTYGIIRFGLQLFPQTWAQFAPVLAIIGTVTVLYGALSAIAQKDIKRMVAYSSIGHMGYILVAAAAGTELSVLGAVAQMVSHGLILALLFHLVGIVERKAGTRDLDVLNGLMNPIRGLPLTSALLITGGMASAGIPGLVGFAAEFIVFQGSFPTFPIPTLLCILASGLTAVYFVILLNRTCFGKLDNQRAYYPKVLASEMIPALVLTAIIFFLGVQPNYLVHWTQTTTNEMIAQLPHETSAIEQLAQGVTLP
The following text describes a protein:
Function:
May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity). May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Subcellular Localization:
Nucleus. Nucleus envelope. Cytoplasm, cytoskeleton. Cell membrane. Note=Associates to cortical microtubules (MTs).
Sequence:
MGKSTKWLKNVLLGKKTSKSSGSKDKERVVSGKEVLVTSKVEESDVVSDLPSFEVAETNTVDRSGGMLETQNVGPEEISDDEIELPEGKSTDSQNVAPVQDHSLSDAERIQREIAATSVQAAFRGYLARRAFWALKGIIRLQALIRGHLVRRQAVATLFSVMGIVRLQAFARGREIRKSDIGVQVYRKCRLQLLQGNKLANPTDAYLGIKKLTANAFAQKLLASSPKVLPVHAYDTSNPNSNLIWLENWSASCFWKPVPQPKKTISRKPQNRLLVEAESAKPKKSVRKVPASNFESSSVQTSFEFEKPKRSFRKVSSQSIEPPAVEDPQIELEKVKRSLRKVHNPVVESSIQPQRSPRKEVEKPKLGVEKTRESSYPLVHETAEEPVNVCDEKKKQEISEQPEEEVHALEMEVHTPGPLETNEALDSSLVNQIDSNEKAMVEEKPSMEKDTKEEKTPKPNNKENSAGKENQKSRKKGSATSKTEREESNGHHETSPSIPSYMQATKSAKAKLRLQGSPKSAEQDGTEKATVPRRHSLPSPGNGRITSHSPRTTRLANSGDKTGNKKEKPLLSSREGNAKTTPAERKR
The following text describes a protein:
Function:
Functions as a zinc transporter.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSQRPTGLKIDMPESFSDQMAKAKKYGNLGANSSGPSSAGPMRTPSWGILNVPELLNDFHHHTLESKLDPVKEGYDEALPMRSRRRTLVNGEIRNSEDREEAAVELDTLKQECDHVIHNHDCDLNEPRIPVYDPLGHIHDHTHDHTHDHIHDHIHDHIHDHTQDHIHDHSHAHAHTHDHKHTHDGHDHSHDHNLTNTHTHTHDHGSCSHGHGHSHSHDPREIPDLQIHIPPLSSLLQSIPSFISLPTSLLATSLLCLQLNVLSPIVSALLVAGCTTFWAGVFRLFGIKHTIGTRKGARNTVVLTAGIFALVISAIFLGTTRVTAIVFVSLNVPLKKVPEWRSSWQYLVYLLISIAHDVVVEGGPLLDFAIGYLALGVAVFVLQQNLETPSSQAIPLGLLITIPTALFVSLTIEQIILLVVACGSCGVFLIAKRDLQPNRINGVFSSLIGFTLDLSIKSRATPSEALVCGLSIFVPTLVSEDGEDASDKSIKKRPGLIDSIISHSDTRNIFYFLLLNFSFMLIQLLYSILSHSLGLLSDSIHMFFDCLALMVGLVASILSKLPPSSRFPYGLGKVETVSGFTNGCLLVAIAGGVCIEALGRIYNPVELERTAELLVVSALGLLVNIVGIVVFNHGHAPGEECSHGHSHGGHDHSEHNSNTYGIYLHIMADTLGSVGVIISTILTWYFGWSGFDPLASMLIAILIFLSALPLVSTAAKTLLLSLTDSQEYTIRNILNDISVMPGVASYDEPRFWSDGGAVRGTIHVKLQQDASSKQVKQTILQRMQQDHVKDVFIQIDA
The following text describes a protein:
Function:
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Note=May be transiently localized in the nucleolus.
Sequence:
MEPEPEPAAVEVPAGRVLSARELFAARSRSQKLPQRSHGPKDFLPDGSAAQAERLRRCREELWQLLAEQRVERLGSLVAAEWRPEEGFVELKSPAGKFWQTMGFSEQGRQRLHPEEALYLLECGSIHLFHQDLPLSIQEAYQLLLTDHTVTFLQYQVFSHLKRLGYVVRRFQPSSVLSPYERQLNLDASVQHLEDGDGKRKRSSSSPRSINKKAKALDNSLQPKSLAASSPPPCSQPSQCPEEKPQESSPMKGPGGPFQLLGSLGPSPGPAREGVGCSWESGRAENGVTGAGKRRWNFEQISFPNMASDSRHTLLRAPAPELLPANVAGRETDAESWCQKLNQRKEKLSRREREHHAEAAQFQEDVNADPEVQRCSSWREYKELLQRRQVQRSQRRAPHLWGQPVTPLLSPGQASSPAVVLQHISVLQTTHLPDGGARLLEKSGGLEIIFDVYQADAVATFRKNNPGKPYARMCISGFDEPVPDLCSLKRLSYQSGDVPLIFALVDHGDISFYSFRDFTLPQDVGH
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and cell cycle control.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAYVKGGVWTNVEDEILRAAISKYGLNQWARVSSLLARKTAKQCKARWTEWLDPTIKKIEWSREEDEKLLHLAKIFPAQWRTIAPFVGRTAHQCIQRYERLLAEVAGEVEGEDASAVASAPATEGDQFPETKPARPDAVDMDEDEKEMLSEARARLANTQGKKAKRKDRERMLEDSRRLSQLQKRRELKNAGIDTRLSKRKKNEMDYNADIPFEHKPARGFYSTAEEEHENDSERLQHKQMHRTAADAPGPSQKRDKATLSKEDEEKKKEQQKTASAQRTLQLAQLDLQDQISKRRKLNLPEPQIQDQEMEEIVKLGAQGEALHKRYADGVASSLSGDYDDKIVDDSIRTPQIQQSKVKTTIEEIKAMENRSVLGKRTEEEVDDEAEADKDGFAIPKLPSNKAVTSVSAGSDIGGATPAGMTPIKRDALGLVGSVEATPVSILRQKLASLPKPKNDFEITAEDEEEDEEADKEKKPTDNLPVDKGEQARLKRIAEEQERQEALKTRSQTLQRGLPRATVPEVTYNDAIGQEVVALLREEELRFPNKGDSVALMQSEFSLDDLVDAETLIEMELMEGDEQEVQEEGIKTAALPGTVARSDESEEEFKTRVEIISDQLVETLTSLAETCQTEETALVDKFKAYAKRQATLSKKLTSRWSQLESVEVEIAVFSELARMEEIAIEQRSAALQEEVDWLVKKERAAQDKYRELKVKEQAAKGGH
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MLQHRVAFRGIRLPFRCVSSLLPRSYSTGIEQHTESISVESSSSSIDPSLSFAPPPVRQDSTINIRKYTPRTPGVRHLRRPINDHLWKGRPVHKLTFPKRGHSKGGRNNSGRVTVRHHGGGHKRRIRMVDFKRDAPGPHIVERIEHDPGRSAHIALLRSKETGKLSYILAADGMRAGDVVQSYMAGIPDDLWQSMGGTVDPGVMAARTAWRGNCLPLHMVPVGSLIFNVGLRPGGGGQLCRSAGTFATVISKGVNQVAAADQESKESQAAGEEKKPMTQREKQARERTLQHITIRLSSGEVRLIHKDCCATIGVASNPNKKYAQLGKAGRSRWLNIRPTVRGLAMNAQDHPHGGGRGKSKGNVDPKSPWGLPAKSGYKTRPKWKINKAVVVPRVRNQGKRRRGYH
The following text describes a protein:
Function:
Formins play an important role in the nucleation of actin and the formation of linear actin filaments.
Sequence:
MHDIDVAIQINMLFLPPTNELIRVDSNSKQLNQPQQQQQQQQQQINNENENSINNQENKENNNKDNNNNNNKEIKQSSEWGSKFSSLFSNMTKKKKSNFDLEMDAIKDAFLLNKPINNEEGLLIYSLDKSKKYIHSLSELDIGYVYLTEKETPIIRQNEDEVILANKVIIQANTMKRFSIKGILQSDVTTNALEIFTKRKMSQGVLFLEEDGSLCRIFYKIQDLITDTIYCNQDDTVMLQKLPNNEGIRFRFRGSFNREQVQQAMLAFSQPSDPQTWKRTIILREQQHHSSQSFTGDSVASRFLNKLSSKTKEDEESNDLKTKRENTVLKLKNRMKIDWDWKYTSTSVPIDQEPPTFIDNMVNRVREKISGSNNKLSDLLSSAKKQPQQQPQKDVTSSSSSSSNSSSPYLDSVDKLVITTNDSSSSNPLPDFDKLSLSSDDKVNNNNVQIENTTPSVPPPPPVGAPPPPPPPPPPPPPPPPSTLKLNRNRISTPKKPNNSGGGGGGGQLTPLQKKMRQLHWNAIPREKLKETFWDNLSPVKGNDNDQTLVESWFSLSPMAKEKMSKENLNNSNNNNNNNSNNNGEEQSLSDSGNTIVISKIIILDLRRSNNICILLSQFKLSYGAIKEAILCFEDGKLSVEQLIALDAMLPISEEEYQSLSSANYQSIEQLGNAERFLIEMMSIQHLQQRVQTYLFKLEVCSLLDSIEINNNQLSKAIEQLRNSRKFIKVLKVIFHIGSILNRGTYLNSTKGFKLDSLSKLSETKSKDQKHTVVDFIEIYIRENQPELLNFYSELDLLDKIPQSSLENILEESNEIENKFKQVDQEIQYHQQLLTNDNNNTLSSSSSSSYDQSKDTYLKVMSPFYDTFNTRFITIKQSTQQTLKQFQECCIYFGEDPQNITSKDFFSNIVKFSIAFKSSSNNAKKSLNLSTLNSK
The following text describes a protein:
Function:
Has bactericidal activity.
Subcellular Localization:
Secreted. Cytoplasmic granule.
Sequence:
MQILTLLFAVLLLMLRAEPGLSLARGLPQDCERRGGFCSHKSCPPGIGRIGLCSKEDFCCRSRWYS
The following text describes a protein:
Function:
Microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage, protecting microtubules from the microtubule-severing enzyme SPAST (By similarity). Induces microtubule branching which is mediated by the formation of long SSNA1 fibrils which guide microtubule protofilaments to split apart from the mother microtubule and form daughter microtubules (By similarity). Plays a role in axon outgrowth and branching (By similarity). Required for cell division (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Midbody. Cytoplasm, cytoskeleton, flagellum basal body. Cytoplasm, cytoskeleton, flagellum axoneme. Cell projection, axon. Note=In sperm, strongly expressed in the basal body region with weaker expression in the axoneme (By similarity). Localizes to axon branching points in neurons (By similarity).
Sequence:
MTQQGAALQNYNNELVKCIEELCQKREELCRQIQQEEEEKQRLQNEVRQLTEKLARVNENLARKIASRNEFDRTIAETEAAYLKILESSQTLLSVLKREAGNLTKATASEQKSSGGKES
The following text describes a protein:
Function:
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
Sequence:
MILVLGVFKIEVEPMLKEMEVLEKGRLLKRYYQRGVVGRNEVVVSYGFIGKVEAALVTQAFLDRFNIDAVFLTGNAGGLEGVEVGDVVIGDSYVEYDFETALGDEGIIVSGSEDLEDKVIAYSNREIKTGLIASGDAFVTVKEKAEEIKRRTGALCVDMDSAAVAKVCYENEKKFLAIKTIVDICGRETEEEFRKNYERYGFLSNLILLDVLKKCVF
The following text describes a protein:
Function:
Is involved in generating a small heat-stable compound (Nod), an acylated oligomer of N-acetylglucosamine, that stimulates mitosis in various plant protoplasts.
Sequence:
METAVCDRPVAMHCVCDLALWDRNPATRRMVLRMNPIVKDCIYYGASRIGELPFFRAHLAARAAIILFHEIQRDARAELMTGTPVALFEYSLNWLRQEGWVIVSVDECIERLARNDRSERYAVLTFDDGYRDNASVGLPILERHNAPFMMYVPTGAPTRSMQSWWLGLRRVFLSRDRVSIDALGRQFQCSDLRSKTSALAEVTRWVHQDYRRGAMLSSVFEESGISLAELNDEYFLDERELCTLARHPLASIGGHSTSHQALSTLDSDSARAELADNRSYLENMLQLPVRHVAYPYGVCGPREEDLARQAGFQTATTTRQGRLYDDKLNRFALPRIGISSPSGLRARMSGIIEGMQAFAKRRVVAELRDHQ
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGSTTTTKKPTKSYSFHEEHHVVNRPSTSYSFHEEGRRNGSSANQHHPRPHRRYVQESSSDGDDKPERVVPRPPSRKYIQQSSDESSSPVPVPKKQLVTTSPPTVLSAKATSSAENTSSEALKNAQVTIEKYKQLYEAILRDPSNAFLFEKKDTLATVASEEAVAKKEGGEVKEIAKDRVVVHGADPPEVKEVDTTIQEKKDPPATNTSELSEWNSNVNVDEIIEGLKLQDILNPQETPSVGSQSILSEIKNSSSSSSSSKNDRQLAPIKPNKRRISSSLNSSLRNSHKSASSTDSHHSHRSHSKSERKRSNRSLQDHHYDRERTSSTTKNEERRSRSSFNLTRSASPGNVSSGTSVSSQKSNKSRSSSTGRNLSFGSRRRFSFSSNAGGSVADDLESQGGFTDCEDDGDVVGDLYNASGTDAKKGKKGLFGKMRKLGAKVSNGVSKVFLPGGSMFRKYKVGEKARYNIGKIRDSLETFDPCDLTVEVTIIAVHIDAVLEIPYYTIQLPDGSRKQTNMEHLMPLEDYNNGRRAESRLGHHRHRSSSRSRSTSRSRSSLVDNDDDQTSVRSNRSTRSTNSSKSLSSRRSSSKRGSSRRSPSPERDSSRRRSISKRHSSKPRDRDRSGSPKRSSSRHSSSRRLSEHSSSFKSTSSSSSRHRMKTPPRSRNGGCSSRCGSDKLSSTRRSSRRCIDEHNDSDYRPRIDAMRGGGMTIPSSDSVVSLKKSDRTVKSKDPQRANDETEEKPTIIKLTRSNTGNSMASSSFALEAAALAIGARRSSASVSSGTKGNESAKEEPPAVMESMLPKAKHSKSSSSDDYELVKSRDKSKRTRSRSIGAPASPVKNCSKCDGSHESSDCPTYLQEREKHKDAWRHYGKKDKKHMGEDGGNVRVKAKRITQPPDGSCLFHSLVHCLNTSKECGGVTPLSSFSNTASSYVPPPLTATYLRRKVASYIASNPELPIADDPLKEWVLWESGKSVKEYAAEIKKDGVWGGGVEIAAVSHMFNVNVHVYERKKSSDEYLRISCFNVDSDVSKKTLHILYQGRNHYDALQLK
The following text describes a protein:
Function:
Catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. Has a role in the repair of breaks in single-stranded DNA.
Subcellular Localization:
Nucleus.
Sequence:
MSSKKRKSPPQESLTSYFEKSSKSSKKYGSQNKDSDSSSTCLQQKIEIQWSITDSLYIAKYGKLKKTKKFIAFDLDGTLIKTKSGRVFSKDAADWTWWHPSVVPKLKALYQDNYSLVIFSNQNGIPRKPSAGHTFQMKIRAIFESLDLPIVLYAAILKDKFRKPLTGMWNSFLKDVNRSIDLSFIKYVGDAAGRPGDHNSTDLKFAENIGIKFETPEQFFLGHSFVPPNFESFHPKNYLVRNSSSHPYHFKKSEHQEIVVLVGFPSSGKSTLAESQIVTQGYERVNQDILKTKSKCIKAAIEALKKEKSVVIDNTNPTIESRKMWIDIAQEFEIPIRCIHLQSSEELARHNNVFRYIHHNQKQLPEIAFNSFKSRFQMPTVEEGFTNVEEVPFKCLKDYEDTWNYWYE