lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Activates the CHA1 gene for L-serine dehydratase. Binds to the DNA sequence 5'-GVGGARAYRTRATTCCRC-3'.
Miscellaneous:
MISCELLANEOUS: Present with 396 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MMLEPSPPPLTTTVTPSLPSSLKKSVTDNDQNNNNVPRKRKLACQNCRRRRRKCNMEKPCSNCIKFRTECVFTQQDLRNKRYSTTYVEALQSQIRSLKEQLQILSSSSSTIASNALSSLKNNSDHGDAPNEKILKYGETAQSALPSSESNDENESDAFTKKMPSESPPPVGTNSIYPSNSLSIIKKKTDGSTRYQQQQVSLKNLSRSPLILRSLSLFFKWLYPGHYLFIHRETFLSAFFGDTNTKSYYCSEELVFAIAALGSLISYKSETELFQQSEVFYQRAKTIVLKKIFQLEDSSLAESSSSSKLAIIQTLLCLAFYDIGSGENPMAWYLSGLAFRIAHEIGLHLNPEAWSNVYEDELSIMDFEVRSRIYWGCYIADHLIAILFGRSTSLRLSNSTVPETDELPEIETGIEEYIYDPKVILSTANPLKKLIVLSRITEIFASKIFSPNETLLQRSEYLAKFNLEVYNWRRDLPPELQWTKRSLMEMTDFNPTIAYVWFHYYIVLISYNKPFIYEIKQSRELVEGYVDELYYLLKVWKNKFKTFEKATIYMIYSAILAIQCMKSNLIKKDRKQDFLNFLSAPTLNYELARKFIENSEDALHNSETMDLLGTLSHGNDFALEYNFDFTLLNEIDMLIGGNTNDGLSK
The following text describes a protein:
Function:
Chaperedoxin that combines a chaperone activity with a redox-protective function. Involved in the protection against hypochlorous acid (HOCl), the active ingredient of bleach, which kills bacteria by causing protein aggregation. Functions as an efficient holdase chaperone that protects the substrates of the major folding systems GroEL/GroES and DnaK/DnaJ/GrpE from aggregation. In addition, it prevents the irreversible oxidation of its substrates through the formation of mixed disulfide complexes. After bleach stress, it transfers its substrates to the GroEL/GroES and DnaK/DnaJ/GrpE foldases. Lacks oxidoreductase activity.
Domain:
Contains an N-terminal mobile Trx domain and four atypical tetratricopeptide repeat (TPR) motifs in the C-terminal region. The Trx domain lacks the canonical Cys-x-x-Cys active site of thioredoxins and is not a functional oxidoreductase.
Sequence:
MSVENIVNINESNLQQVLEQSMTTPVLFYFWSERSQHCLQLTPILESLAAQYNGQFILAKLDCDAEQMIAAQFGLRAIPTVYLFQNGQPVDGFQGPQPEEAIRALLDKVLPREEELKAQQAMQLMQESNYTDALPLLKDAWQLSNQNGEIGLLLAETLIALNRSEDAEAVLKTIPLQDQDTRYQGLVAQIELLKQAADTPEIQQLQQQVAENPEDAALATQLALQLHQVGRNEEALELLFGHLRKDLTAADGQTRKTFQEILAALGTGDALASKYRRQLYALLY
The following text describes a protein:
Function:
Part of the postsynaptic scaffold in neuronal cells.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Postsynaptic density. Synapse.
Sequence:
MKGLSGSRSHHHGITCEAACDSLSHHSDHKPYLLSPVDHHPADHPYYTQRNSFQAECVGPFSDPLASSTFPRRHYTSQQELKDESALVPRTLATKANRLPTNLLDQFERQLPLSRDGYHTLQYKRTAVEHRSDSPGRIRHLVHSVQKLFTKSHSLEGPSKGSVNGGKASPDESQTLRYGKRSKSKERRSESKARSNASNASPTSPSWWSSDDNLDGDMCLYHTPSGVMTMGRCPDRSASQYFMEAYNTISEQAVKASRSNNDIKCSTCANLPVTLDAPLLKKSAWSSTLTVSRAREVYQKASVNMDQAMVKSEACQQERSCQYLQVPQDEWSGYTPRGKDDEIPCRRMRSGSYIKAMGDEDSGDSDTSPKPSPKVAARRESYLKATQPSLTELTTLKISNEHSPKLQIRSHSYLRAVSEVSINRSLDSLDPAGLLTSPKFRSRNESYMRAMSTISQVSEMEVNGQFESVCESVFSELESQAVEALDLPLPGCFRMRSHSYVRAIEKGCSQDDECVSLRSSSPPRTTTTVRTIQSSTGVIKLSSAVEVSSCITTYKKTPPPVPPRTTTKPFISITAQSSTESAQDAYMDGQGQRGDMISQSGLSNSTESLDSMKALTAAIEAANAQIHGPASQHMGSNAAAVTTTTTIATVTTEDRKKDFKKNRCLSIGIQVDDAEEPEKMAESKTSNKFQSVGVQVEEEKCFRRFTRSNSVTTAVQADLDFHDNLENSLESIEDNSCPGPMARQFSRDASTSTVSIQGSGNHYHACAADDDFDTDFDPSILPPPDPWIDSITEDPLEAVQRSVCHRDGHWFLKLLQAERDRMEGWCKLMEREERENNLPEDILGKIRTAVGSAQLLMAQKFYQFRELCEENLNPNAHPRPTSQDLAGFWDMLQLSIENISMKFDELHQLKANNWKQMDPLDKKERRAPPPVPKKPAKGPAPLIRERSLESSQRQEARKRLMAAKRAASVRQNSATESAESIEIYIPEAQTRL
The following text describes a protein:
Function:
May be involved in the transport of sterols.
Sequence:
MIQDEAAAGPRATTAVLTPPLSLDGGLAAEHRPPNLLRRVLSFFGSVRPGSDLTQFQLPSLFNMPKSQLQCYGEAVYCFGEDYLNKCAKGKSSLERFASVVAWSISTTRPALFGQAPFNPILGETHHVSRGSLNVLLEQVSHHPPVSALHATDAKDNVELIWCHKPVPRFHGASVEAVIKGKRHLRLLKFGENYEMDSPNLLIKLLPTTGADWVGDVSIRCKDSGLEADLCYYKSHAFLGFGGSSKSIRGKIFHSKTLKTIYEIDGQWDRIVKLKDVHSGEVTILYDAKKAISGLKTPILQAPQNLWPTESATVWSEVSQAILNKEWGKASAAKQIIEEKQRKLQRERKSSGELWVPKHFTVTHTKENEWDCSPLEQSVPPAPIIVHP
The following text describes a protein:
Function:
C-methyltransferase that methylates 8-demethylnovobiocic acid to produce novobiocic acid in the novobiocin biosynthesis pathway. Novobiocin is an aminocoumarin family antibiotic that targets bacterial DNA gyrases.
Sequence:
MKIEAITGSEAEAFHRMGSQASHRYDEFVDLLVGAGIADGQTVVDLCCGSGELEVILSSRFPSLNLVGVDLSEDMVRIAREYAAEQGKALEFRHGDAQLLAGMEDLAGKADLVVSRNAFHRLTRLPAAFDTMLRLAKPGGAVLNCSFIHPSDFDESGFRAWVTFLNQRPWDSEMQIVWALAHHYAPRLDDYREALAQAARETPVSEQRVWIDDQGYGVPTVKCFARRAAA
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
METSINLELDSFGEEDDDDLPAVTRLPALDEDDDRENFLNTSGQRNEGLLDTLLDPAGAEEGADAVGKRVVNRKPIPKLDATRLTGDRGLPILVKHFEKVKFKGKGHEASDLDRLMRVMEHWAHRLFPKMPFDDVIERIEKLGSKKPVQTCIRKIRLDMPLLDEDFVTRGEDVIEGEDGEAATGLGDDFPAPSFPGTQQPPSTINTPKVSMSDEQRERIELNKRLAMERRLNKQKEAKSSQKPAASQSDGLNEAEIHDLFGTGKAKTRVEDDDGIDSDEDEMEREMWESQMTGGTKDKKASQKGAASGEVEIDADEAEMENEMWNQMTQPVSTQSQMSRSQETTPKVAKKSNKNEGIIEDESDAEEMKTAKDSQFVGSQDEAPKRGRRNKRVIDDDSDDDDDVMEMVKDSQTAASQVMQSKGAKKRRVIEDDESDDEMEAEDSNKMTELLSPKPPKDGPEETSASRSLTGSQKSVRIDGEEEPDVVAEEDDDDKKKDPQNAEVENDICNQMTEPVLSHKPTDPNSLLTSQETSNSNSLDEVINDDDSGEIWNQMTEQVKTQIVNDSQADDQSYNVLKSKKRVIEDDDDDDDETQIDLDMCNQETEPVNTGNSQDTVET
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MSENGEEKLLAVARHIAKTLGQTNHNMTDDILQIFSNFDGRFSKENLSDSAPRNDTIRYTALEQTLNNLDRQISHHLSSEIPTVASAAFLSSVDELVAIIEDWSPLSDDKTVGACLLRAEDILQQAMFRAEEEFRSLMELGGASFNGEMNLNCNSLYETNDEVDEDEEEEIDGDEDLIPVAKAVVDYNVVIDALPPATVNDLREIAKRMIAAGFGKECSHVYGGCRREFLEESLSRLGLQKLSISEVHKMQWQDLEDEIERWIKASNVALKILFPSERRLCDRVFSGLSSSSAAADLSFMEVCRGSAIQLLNFSDAVAIGSRSPERLFRVLDVFETMRDLIPEFESLFSDQYCSFLVNEAITNWKRLGEAIRGTFMELENLISRDPVKAVVPGGGLHPITRYVMNYLRAACRSSKTLELVFKDNALSLKDYHKHDESLQSNSSFSVQISWIMDLLERNLEAKSRIYKDPALCSVFMMNNGRYIVQKTKDSELGTLMGDDWIRKHSTKVRQCHTNYQRSSWNKLLGFLKVETLAAKPMKEKLKMFNLHFEEICRVQSQWFVFDEQLKEEIRISIEKLLLPAYGSFIGRFQILPELAKNSDKYIKFGMEDIEARLNNLFQGSGGSNGSRK
The following text describes a protein:
Function:
May be directly involved in signal transduction and/or cell cycle regulation. It is necessary for maintaining growth rate or spore germination. Could show both activity toward tyrosine-protein phosphate as well as with serine-protein phosphate (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSNKSAWQPQFDEIHSSVQEAEGFLQSSNDVQKAIDEVHYPDSLNDLSEISKNLYISSWKTASELVSTSDKGIDYTLSAMSINPNLSVPEQQHLWLQIEDSSSQNILQYFEKSNKFIAFALSKNAKVLVHCFAGISRSVTLVAAYLMKENNWNTEEALSHINERRSGISPNANFLRQLRVYFECNYQLDRSLRPYRQWLFRRYGDFAVLNTRVPSEVAYAETVRARAGQLELRCKKCRFVLASSDYLVSHEPKDENNYSHTRCTHYFLEPIRWMQPELELGNLEGRFDCPKCNSKIGSYKWQGLQCSCLQWVCPALSILQSRVDAVRKLG
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MLLVDLASKACRDPTNYAEEVQKQLLVLRSQLELIQSSSSLTSEEEFVDLLNFTARLSGIAQYNAIYSSLIPILITFTESSALLLSPPLRQTLVQTLILFVKRGVLSLTDTNLLSLYCGLLRIHDKPIRQLVYSHLLNACIKLFKAGKTGASQKILSFFNMKMRDGNALLAFKLTQLCCDLYSKHAWENERTMSVILDSLLNSNDKRISLLVLHFLLLENTAAAKDSDEEEDDQGVTKDEKKEALKAKIRHLRAVSSFAGNQTKTHKTLAKAQKSLKNLMDENNEEKELTYAGSRHPYDNIRDPYVFIEKLCHKYLGRNTSFQLKLLTFEVTSKIIAHHSLEIQNYYRYYMKYLKPQQKDVIKILEYLVSSVHPAIFDEEVFAVMKVIAHEFIHSGSTDYIMTVGLNAIAEMAKRNPNALIANPSACELLNELASYSKEAVVARSYQNSKCKTTSKTRRGVMTAARCLLQFYREQAPDKLEARFQNRDSAQVVRQLKAIERLAQKGQVTEDEGEEDDGDDHGAEEMEELEELEELEDLEELEEFEELEDIEEFEETSSRDKTGTTQLMGNQKAVPKFGVPLSNKKIDSSDFSRRNIAKLLKETYSDDEGEEVAPSKHQLKKMKLERNKMGHILVNCKKRGLPIPECYFTRINELFGPIDEYGNPKEQDSEEEEDEGQNIDGDAIEPESGEPGKCIRIIRGKRGKKRAILVDAESADRSEADSSAGENDSNVPLQSRRLLTDEELARISEYVTPARMNEVDLESFLPRKKLTRAEKTVLAHSGRSANDHKGSRWAESIARKLESNKSLSNIQKQKTTKNMLMLLHSQRVRNKRARSGAEKDRIARSHTRNQKLGISKKATARRN
The following text describes a protein:
Function:
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.
Sequence:
MGKIRVRNNNAASDAEVRNTVFKFNKDFGQHILKNPLVAQGIVDKADLKQSDTVLEVGPGTGNLTVRMLEKARKVIAVEMDPRMAAEITKRVQGTPKEKKLQVVLGDVIKTDLPYFDVCVSNTPYQISSPLVFKLLQQRPAPRAAILMFQREFALRLVARPGDPLYCRLSANVQMWAHVKHIMKVGKNNFRPPPLVESSVVRIEPKNPPPPLAFEEWDGLLRIVFLRKNKTIGACFKTSSIIEMVENNYRTWCSQNERMVEEDFDVKSLIDGVLQQCNLQDARASKCGQTEFLSLLHAFHQVGVHFA
The following text describes a protein:
Function:
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
Sequence:
MNRLALYGALSSLKPAGTPRKYGICLVSRNVSTALRPLTLSSPRVRAIGPQLLRWNSSQEPLPEQKVLKQELKEEVPPPKQEERKQEDPLRFSVKRDVAEGPSGERNNLSSLAGKPAFSLHTGEKTVTLPVNRFENSSRAFLKWWLRDNCQCDKCVHPSTRQRIVDTFSIPDDIGVKDISNGRSQVTVTWSDGHVSSYNHSWLAQGGRRAPTSLGEYPLRFRKGMTYNPKHEGNVKEMPSVSYSEVMANDAGVLKWLERIYDWGFCLVRDTPINPECTEALLRRIAHIRHTHYGGFWDFTADMSFKDTAYTNEALGAHTDNTYFTDPARLQLFHMLSHTDGDGGATLLVDGFRAARRLYAESKQNLNHLRNIRQPFHASGNEDSIYQPVEQQVVLRAHAQFKHRLYQVRWNNYDRAVKWNWSLEEQEAWYKAAKHFNDIIHREDMEIWTQLQPGTALIFDNWRMLHGRSAFTGKRRMCGGYISNDDFLSRYRVLKFGRDHVLRRLGDLRDYPTNPSCIF
The following text describes a protein:
Function:
Endolysin that degrades host peptidoglycans and participates in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles (Probable). Exhibits lytic activity against Staphylococcus aureus isolated from human and bovine samples, as well as Staphylococcus epidermidis isolated from human samples, although with lower lytic activity. No lytic activity detected against several lactic acid bacteria and strains belonging to Bacillus, Streptococcus, Clostridium, Listeria, and Enterococcus. The CHAP activity cleaves the peptidic bond between D-Ala and Gly in the host peptidoglycan (By similarity). The N-acetyl-muramidase activity cleaves between N-acetylmuramic acid and N-acetylglucosamine bonds (By similarity).
Domain:
Contains a cysteine-histidine dependent amido-hydrolase/peptidase domain (peptidase C51/CHAP domain) at the N-terminus, a central amidase domain and a SH3b cell wall-binding domain at the C-terminus (By similarity). The CHAP domain is present at the N-terminus and is associated with the endopeptidase activity (By similarity). The SH3b domain increases the CHAP domain activity (By similarity).
Sequence:
MQAKLTKKEFIEWLKTSEGKQYNADGWYGFQCFDYANAGWKALFGLLLKGVGAKDIPFANNFDGLATVYQNTPDFLAQPGDMVVFGSNYGAGYGHVAWVIEATLDYIIVYEQNWLGGGWTDGVQQPGSGWEKVTRRQHAYDFPMWFIRPNFKSETAPRSVQSPTQASKKETAKPQPKAVELKIIKDVVKGYDLPKRGSNPNFIVIHNDAGSKGATAEAYRNGLVNAPLSRLEAGIAHSYVSGNTVWQALDESQVGWHTANQIGNKYGYGIEVCQSMGADNATFLKNEQATFQECARLLKKWGLPANRNTIRLHNEFTSTSCPHRSSVLHTGFDPVTRGLLPEDKRLQLKDYFIKQIRAYMDGKIPVATVSNDSSASSNTVKPVASAWKRNKYGTYYMEESARFTNGNQPITVRKVGPFLSCPVGYQFQPGGYCDYTEVMLQDGHVWVGYTWEGQRYYLPIRTWNGSAPPNQILGDLWGEIS
The following text describes a protein:
Function:
Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation.
Sequence:
MDPRIAWFQPEQLGPANNLWMQIWETTQGFGYLYVNNCYTAGPQNTSSLKTAVNGWLGAALSTSRNGSTLDSSTAAGEAKTQVMSVSTGDGDVTEQRDFIPLDSQSNRNNRGGVVGEGGHQQQGCGVTVLYRGHADGHPNKRKRENKASTYGFNSSLLNNFNSGGHEAYTGTPWKTRNYADTVVGLHEEIKDFYDYISPRPEEEKMRLEVVDRIKGVIHDLWPSAEVQVFGSFSTGLYLPTSDIDLVVFGKWETLPLWTLEEALRKRNVADKSAIKVLDKATVPIIKLTDSVTEVKVDISFNVESGVKAARLIKEFKEKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHFREDVCSPNINIGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMMDGYRPSMLYIEDPLQPDNDVGRSSYGAMQVKQAFEYAFVVLHHAVSQIAKCYPNNESESILGRIIRVTKEVDEYREWIRNNWGNSSQIDLPLNKNDVKLLDPQQLDERNNNVPDDEVVVVLPLAPRSKTFSNTSSPPPSLRSSHSSSPLSPPSTSPTSTSSDADSDGTPCKTAKQQPGRGPGTLREKPAVATNHRTQNQSTITPTTGNKGGKARMSRAHHNNGHQGQQNSTKTTNNPKNKLVHQGNSKKRKNVRDSTQEDLYR
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MGITDMVLFGLLLVNALLPVDTSGRMPFTYRNQLQRLCSSTEYTSLCVQTLREFRHGSPTSLDFVSFLVNKTMSGSSNLIPPLSSSMASYEVISLDDSTNTLPSPSVADSCERLMKMSTRRLQQAMEALNGSSRKRTTKHDVQTWLSAAMTFQQSCKDSVLDSGGHSSSAVSHITQKMDHLSRLVSNSLALVGTFMENPKPTVLPRWVSAGERKLLASRTSRSRPHVLVAKDGSGDYRTVMEAVNAASGNGRFIIYVKRGIYKEKVRIEKDEITLIGEGKDLTVIVGDDSAAGGTSVPDTATMTVTGDGFIARDIGIKNTAGPRGKQAIALSITSDQSVLYRCSISGYQDTLYAAALRQFYRECDIYGTIDFIFGNAAAVFQSCNLILRRPSDVKAYNVILANGRTDQRQNTGFALHSCRILTDLDFSGMKHRYSSYLGRPWKKYSRSIVMETYIDDAIAEEGWAGWLNSGDEVLKTLYFGEFKNYGPKARVSKRVWQGFHVIGFEEASYFSVGKFLDGVSWLPSTGISFASGI
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGEPVKVMSTFGSIYGHRPEVALRLKGIPYELLLEDLPNNKSELLLTCNPVHKLVPVLLHGDRSICESLIIVEYIDEAFKGPPLLPAEPYERATAHFWAQFIDQKFARPFWMSICMADGDKEEEEEDFLKEAKANLLLLEGQLKVEEEISGVDLLTDEKFPALNRWAKEYAGDEHAKECLPNKDELVAKFTAVKKKFLAMAEVQK
The following text describes a protein:
Function:
Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endonuclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.
Subcellular Localization:
Mitochondrion.
Sequence:
MKAFQTICRQLKSSKGFSVEPASHVVFSTSSYLCGRKKKVNPYEEVDQEKYSDLVKSVLSFRGHAQTPESLFKEDALLYGPVSKCKASKQEEEAGVPQNWFPLFNPEKSVKPTATSDPTIPLKIPLQRNMIPSVTRVLQQTMTSEQISCLERWKQRMILQLGEDGFAEYTSNMFLQGKQFHEALESILSPQGNLKERDKNLDSGYVQSVQHVLKDVSGVRAVESAVQHETLNYIGLLDCVADYQGLCVIDWKTSEKPKPYIRNTFDNPLQVVAYVGAINHDSNYSFQVQCGLIVVAYKDGSPAHPHFMNAELCSRYWAKWLLRLEEYTKKEKNQDIQKPH
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGRAKPAAAKAASPAKPAEEDAPEPIKLTNLYDAGALKGALDEVAREVVLDAGFNEDVMVSNIKLLLGFTAIGSGLLAQFGPGKFPANWWMVFGCVVAYLVLTTLLNLYSWKVEGEAFLVTRPFRGGKGVRVSSRMGRWSDEFTLVITDREDPSLEVTSQHAIPEFFHSNGYMADGAWRAAVEKLTSSYLERLAARRGKKDD
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.
Miscellaneous:
MISCELLANEOUS: Present with 222 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol.
Sequence:
MSFGGINTFQQYNTDLGLGHNGVRISLNYFDGLPDPSLLNSLYSNELKLIFKSLLKRDETTKEKALMDLSNLISDFNQNEYFFNDIFLLCWSQIYAKLIISDYKVIRLQSHQITIMLVKSLRKKISKFLKDFIPLILLGTCELDYSVSKPSLNELTECFNKDPAKINALWAVFQEQLLNLVKEIVVNENEDTISDERYSSKEESEFRYHRVIASAVLLLIKLFVHNKDVSERNSSSLKVILSDESIWKLLNLKNGQNTNAYETVLRLIDVLYTRGYMPSHKNIMKLAVKKLLKSLTHITSKNILKVCPVLPSILNLLATLDDYEDGTIWSYDKSSKEKVLKFLSVSRTSPSPGFFNAVFALYSSTKRHSFLDYYLEWLPFWQKSVQRLNEKGFSARNSAEVLNEFWTNFLKFAEDSSEERVKKMVESEIFNSLSCGKSLSEYTKLNQTLSGVFPPDKWEREIEDYFTSDEDIRKIKVSFEKNLFALLVTSPNNESAISRLFDFFVQLIETDPSNVFNKYDGVYDALNYFLDSDMIFLNGKIGKFINEIPTLVQESTYQNFAGIMAQYSNSKFFKMNTDAITSLEDFFIVALSFNLPKTIILATMNELDNDIYQQLMKSDSLELELYIEDFMKNYKFDDSGEIFKGNNKFLNQRTITTLYRSAVANGQVEQFCAVLSKLDETFFSTLLLNTDFLSCALYEVSEDTNEKLFKLSLQLAKGNSEIANKLAQVILQHAQVYFSPGAKEKYVTHAVELINGCNDTSQIFFPANAIEVFARYMPAIDYRSSLVSSLSTNTHLLLTDDKPINLKNMQKLIRYALFLDALLDALPERVNNHIVAFITVVSELVTDYNCLSEEPNDLYYDFGHTFFKHGKVNLNFSDIVGNVIQPANGGDAMLTFDIAESNSVYFFYYSRVLYKVLLNSIDTVSSTTLNGLLASVESFVTKTVRDQKSTDKDYLLCAILLLMFNRSNSKDEITKLRTLLASQLIGIREVELVDQEFKSLALLNNLLDIPQADKQFVPIAPQRLNMIFRSILKWLDSDLAYEPSFSTVRLLLLDFFTKLMRFEGVRDMGITAFELSERLLADSLSMCQIDDTLYLLELRSSCLNLYETLSQGVSKNGEEISEYGDEIQENLIELMFLNFNQERNNQVSTLFYQKLYKVISSMELKKLESQYKRIFEVVLNDKDIGSNINQSRLLTTLLGSLVVKTQQDIIIEYELRIQKQTGSDVDGSASDNDVNSKFKLPQKLLQKVTDEVPKEYLEYENKNSFIKYLWYWHLILMYFKDTSYNMRQIFIEQLKEAGLINRMFDFITDQIDLRDTEFWKQVDTKEISEYNIVGNNFSPYKEDIFEECKKLLGHTLYQLFNNVGCLTSIWWLNIKDRTLQNDIEKFVSEFISPILIKNEFDDINSKMDRLTSNDDALTIKLNNITNEVKASYLIDDQKLEISFKLPKNYPLTNIQVNGVSRVGISEQKWKQWIMSTQHVITGMNGSVLDSLELFTKNVHLQFSGFEECAICYSILHAVDRKLPSKTCPTCKNKFHGACLYKWFRSSGNNTCPLCRSEIPFRR
The following text describes a protein:
Function:
Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.
Subcellular Localization:
Mitochondrion.
Sequence:
MSRIGSVTRVARAARAATTGVARNLSSTSYQAGFKPLVASNGFNGAIGNTPLIRINHLSDETGCEVYGKAEFMNPGGSVKDRAALYVVEDAERKGLIKPGGTVVEGTAGNTGIGLAHVCRAKGYKCVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFDNPQNYNHLAKAHAEKLGAGNAVWTNQFDNVANRQAHIETTGPEIWAQTDGKIDAFTCSTGTGGSFAGTMRYLKDVSHGRVQCILADPPGSVLHSYVQSGGKLTERAGSSITEGIGQGRVTENLAPEIAEVDGSVQIPDQATIEMVYNLLDKEGLYLGASSCLNVVAAYEVAKQIGPGHVVVTLLCDGAHRYADRLFSKKWLESKGLTIPENLQKYVVLD
The following text describes a protein:
Function:
The central subunit of a protein translocation channel (Potential). Part of the accessory SecA2/SecY2 system specifically required to export SraP, a serine-rich repeat cell wall protein encoded upstream in the same operon.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLKLLQQYEYKIIYKRMLYTCFILFIYILGTNISIVSYNDMQVKHESFFKIAISNMGGDVNTLNIFTLGLGPWLTSMIILMLISYRNMDKYMKQTSLEKHYKERILTLILSVIQSYFVIHEYVSKERVHQDNIYLTILILVTGTMLLVWLADKNSRYGIAGPMPIVMVSIIKSMMHQKMEYIDASHIVIALLIILVIITLFILLFIELVEVRIPYIDLMNVSATNMKSYLSWKVNPAGSITLMMSISAFVFLKSGIHFILSMFNKSISDDMPMLTFDSPVGISVYLVIQMLLGYFLSRFLINTKQKSKDFLKSGNYFSGVKPGKDTERYLNYQARRVCWFGLALVTVIIGIPLYFTLFVPHLSTEIYFSVQLIVLVYISINIAETIRTYLYFDKYKPFLNQYW
The following text describes a protein:
Function:
Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis. In vitro, recruits the ubiquitin-conjugating enzyme ubc-2 to exert ubiquitin ligase activity.
Subcellular Localization:
Nucleus.
Sequence:
MEQQIQMDEQENDESQGNDDQQNMSMSSSELHTMQDDHPGILLKTNTRMSITVKKLHVCGEWKWLQGGEDTCGICRMEFESACNMCKFPGDDCPLVLGICRHAFHRHCIDKWIAAPTNQPRAQCPLCRQDWTIVE
The following text describes a protein:
Function:
May act as a negative regulator of abscisic acid (ABA)-mediated osmotic stress signaling and function in cross-talk between cold and osmotic signaling.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDQNGHNDEAETVSCGNGNCKSKIVPGDDHGGDESSGTKRRKKRKTQQKTMKRRELMSYCELPEYMKDNEYILNYYRADWSIRDAFFSVFSFHNESLNVWTHLIGFIFFVALTVANIIHHDGFFPVDAKSPGNVTRWPFFVFLGGSMFCLLASSICHLFCCHSKELNVFLLRIDYAGITAMIITSFFPPIFYIFQCTPRWYFIYLAGITSMGIFTIITLFTPSLSAPKYRAFRALLFASMGLFGIVPAAHALVVNWGNPQRNVTLVYELLMAVFYLVGTGFYVGRVPERLKPGWFDRVGHSHQIFHVFVLLGALSHYAAALLFLDWRDHVGC
The following text describes a protein:
Function:
Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces.
Sequence:
MDVDGDRIRLVGGRFPNLGRVEVRPVGSYGWGTVCDDSFDIQDATVVCKMLGFDRALQYHDAAHFGQGSGNIYMDELRCSGNETSLFACGYDGWGNHSCSHSEDVGVTCASNPGSSRIRLSGGYRGSQGRVEVRPADSYHWGTVCDDEFDRDDATVVCRMLGYSDASAVRHSAYYGQGMGPIYMDNLECAGNETSVFYCPYNGWGNENCGHSEDVGVMCECWHPLTAPSGGPFTSPNYPSNYINDETCRWHITVPTGSRIRLTFDSFDVEEGRDFLDIYDVDDITRPTNATGCGGLLKSSSGGIVTSPNYPSHYGNNEVCDWLITVPVGSRIQLTFDSFNVQYDHDFLNIYDGASACASPLRRLTGSHPVNITSTSNVMFLRFTSDEILTAQGFQLSYTITTCGGNLTAPSGGPVTSPNYPNNYDNNEICEWLITVPEGNTIRLTFESFDVGSSLDVLTIYDGASDCDFVLASISRWGAFYPIISTSNVMFLRFTSDSQNNETARGFQFSYTNHTKSINDIVCGGNLTAPSGGPFTSPNYPGHYGDNETCEWWITVPAGSTIRLTFDSFDVGFNEHLDIFDGPCATTPGASGCGFNPIAHSGGLVRFYSWNSEHVICEWLITVPAGSTIRLTFDGFNVDYEEERNVLDEQMVPVSYTSQTTPTNVTYCGGNPTSPAGGPFTSSNYPGNYGNNEVCDWLITVPTGSTIRLTFDSFEVEDGYDFLNIYDGADVRASLLRSFTGSESISPITSTSNVMFLRFTSDHILTSQGFQFSYTSHTVDYCQPDPCINGTCSSGADSFTCTCDDGFEGETCQNRVVVVSADLTLAGEVFTDDLNDMSHPRFRMLARAIEIETSLAFAAVPSFRQATVTRFRMGSVIATVDMEFQDTGQAPGSDEVVMVATLQKYISDNGGRLGNLSVSQVDPVLSPGKCESASN
The following text describes a protein:
Function:
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.
Subcellular Localization:
Cell junction. Cytoplasm, myofibril, sarcomere, Z line. Nucleus.
Sequence:
MTDRSPFETDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKAISSAVRKAGLAHLYGIAGSVNVTGDEVKKLDVLSNSLVINMLQSSYSTCVLVSEENKDAIITAKEKRGKYVVCFDPLDGSSNIDCLASIGTIFAIYRKTSEDEPSEKDALQCGRNIVAAGYALYGSATLVALSTGQGVDLFMLDPALGEFVLVEKDVKIKKKGKIYSLNEGYAKYFDAATTEYVQQKKFPEDGSAPYGARYVGSMVADVHRTLVYGGIFLYPANQKSPKGKLRLLYECNPVAYIIEQAGGLATTGTQPVLDVKPEAIHQRVPLILGSPEDVQEYLTCVQKNQAGS
The following text describes a protein:
Function:
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
Sequence:
MESCVCQVLEMAASQEKQLNLAKQFAQNSDGCEGRGSGSCGGSAFVWVACPFIDSPVSFMDSVPSLEILVRAPEGFSLWCGPPFNNGQPAVKLEKVICTNAKFSEDGSRLMVMKSDSTVSIYDCSSSKEIRSFAVPNMSAATMSPCGTYLQTFQRPSTPQEKNVILWKTETGAPVYQHFQKNMTKTTWPSVQFSSDEAIACRLATNEIQFFDARDFSKEIIYRVRIPGIAAVELSKAPGSHVAAFIPESKGIPASVQIFACGENSMSQPVARRSFFRCSTVQLSWNRGSTGLLVLVQADVDKTNQSYFGESKLNYLTTNGTHEGLVPLSKEGPVHDVQWSYSGSEFAVVYGFMPAKATVFDKKCNPLVELGTGPYNTIRWNPKGKFLCLAGFGNLPGDMAFWDYKEKKQLGTTRAEWSVTSEWSPDGCYFMTATTAPRLQVDNGIKIFHPNGSLYFKTMFDKLYQADWKPESPDRFGEIAELAQSIDSLKVGETKQQGQGSKSSVAPNKATSANPPTQKPAAYRPPHAKTAAAIQTKLFGGSSTEEMSKNAAKNKKKREKQREKKAAEAATAANNGA