lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MDDIPPYPPIDPTTFDLIVIGTGLPESIIAAAASTASKSVLHLDPNPFYGSHFSSLPLADLPSFLSSHSTSPSPPRSPSSDDPNEFSLLEFATRPLYSSIDISTFSPNLDQHSRKFNLDVAGPRVLFCADKSIELLLRTGTNQYMEFKSVDATFVGDNKGNLWSVPDSRAAIFKDKSLGLVEKNKLMRFFKLVQGHLAGEQDVKISEEDLQSPFVDFLNKMGLPPKIKSFILYAIAMADYDQEDTGVCRDLLKTKDGIDQLALYNASIGRFQNASGAFLYPIYGQGELSQAFCRRAAVKGCLYVLRMPVTALLVDKDTGCYKGVRLASGQDIFSQKLILDPTFKVTLPLGSSPPLPLKEKLPFFSLKDDKGKIARGICITKTSLKPDISNFLVVYPPRSLFPEQVTSIRLLQIASNLAVCLPGMFVLYISALCNDDDQGKKLIHAVMNTLLTVPLDSESNAAVQSETAEIGSAVQDETSESSSGGPSDSGEEKPTLLWSALYSQELTLGQVDFICSTPMPDGKLNYNDLIDTTFKIFQEIYPEEEFFPETSLENPEVDGDASPET
The following text describes a protein:
Function:
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MTYMYPNYVPINMTSGNMLEPGVASKGKYGLFLYAEGWRNVDFRESLRRLSGVPVLFIPGNAGSYKQVRSMASESTRQFESGFTPAAAPVPTTIPRAMLEGAHKCSKERCQYASRLDWFAVDFLEEYSALDSRILQDQTEFVVKAIEKILDLYKQAARFRRIKRGRKRTRQLPTNVILFGHSMGGVAARAALFHPAFREGSVKTIVTVATPHRSPPVPLQLSGSLFYSNFNRKWRQGFADTGPLRDVIVVSISGGSRDTQVRTPLMRLDGIVPPRNGFSVSASAVPDVWLETDHQVIVWCNQLVVKLSKALLLLSDPATRQPHDSRVVRREILAANLRSALPEALGWLPRGSWTGDLDSEDLAEIQSLLPPGKGLQKAGEGVNDGQGDATTKEASDGAEGFEPELEREVTSEESSKSGIASGPGYRSLPEKEPTSQTLRAKADGRDSERETSREETVSAKRAERGRNDQKAERKRTDEADSERTHAKRYGRACPSASELDGTAEREVVSGSFLALENADARQRWFDVRAGRQGLTKPPVLVTSRGFVVLFNLEPCTEVRMWMVRGSTSAEPVSRKEGNSSGRTEPEQQAADAEREEAKQQGRGKGLDSKGAGVERPSAESEQRGAEQRGAEPERRGPEADRRNAAEGVTSIPGAAKRSNESLEEERASGVDGTERVRNEALDRAEQKRNAGRAVSEVTLQAGRLPAGSLLSQSGSDRPTWILRLLPEELADVDWVVIETSRADESPPAAEPVLFAQLIQPGEGTLQLGWRDLLATSIFPRVLTLPEGHSLWTEVTAPLPLSLLPMTLRFTQRDCPAVQKGDPKLDTGTCSAPCSPPLVLAWDPSIEQERIWTVTNATTLQTDGSPGGGASKGGTNPPSVILSDPRCGYRVSVTIAPHLACFRFLATNAPRIVSFAVALVLFILAVQSHPRKPGKQTPNPVAALCQLLTLQTTPLTLRSLLLGLQTPLRTRLPVSLVVVALAAALIPISRSLEAARAIRVTSADVYLLTSSALAMTFAVGLVALLAAAQATLLRLVFWSLQRFRSTQKTSCTAPEWKHDWRLTGTTRVFVGCFSVAACLLIHPAIALLVILVVRTLDTVTESCRSRDHDERRTLVKEPSADTSTDGRSVVANGEQTGKAGVATAVPRGSTGYGHVSTKDQCGAALQRQSGCLLLAFLNFVVTAPSGFASLPCVLRRWRAPSALNSLLVIAPIVEALLSPHDRLQGGRNRIGCSINQTVRSCLYVLLGAYACYEGLVESPLGAAPVFTFAALVGLFFS
The following text describes a protein:
Function:
Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA). Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTAEQALPLGNGKAAEEARGSEALGGGGGGAAGTREARDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIVSYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPRMVTVNDCEAKVKGDGTISAITEKETHF
The following text describes a protein:
Function:
May transport inorganic phosphate (Pi).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKFGKEFKQQKVPEWIEAYMDYNGLKRILHEIKQSKLQEEPQTPSRISQQRLSLYRPFSGLNVRSSSDDESTDDVEDQVIAVETVRQDDTREVYNTNFLMSPRQSEVTFFEKLDEELNKVNTFYRDKVEEVIEEATSINKQMNALIALRIKVEQPDINKCHIQRIISTDSGSIESSNINSPSRVSLENRHIDSKSDKHKSDLLDVLDRVKINNTLESPMSTIRSVLNDSKDKDLRFKKEELKEAEGRMKVVFIEFYRKLHLLKHYSYVNILAFSKIMKKYEKIAIRRAARSYMKIVDDSYIGSCDEVTLLLDRVEGTFIKYFANSNRREGFFSGCSIALLIAAILLIQARKVMSKQEHTMYMENVFPLYSLYAYIILHMLLYAANIYFWKRCRINYPFIFGFKQGTELSYQDVFLVSTGVTVVTLSTFLLHVHMKLDSVHSIYEKYVELIPLILLILLLLIFFCPFNILYKSSRFFLIKSLFHCICAPLYKVSLADFFLADQLTSQIQAMRCLEFYICYYGMRWYQKEQKCHTMDLYNVFYIIVAIIPYWIRFLQCVRRLVEEKDWVHLINGSRYLLTIIAVVFRTVFELKMKKTWKVLALMTSIASIMFNTYWDIVVDWGLLQRKSNNLFLRDKLSVRHTSVYFVVMVLDVMLRLTWLQLILKFNLHYLKGTAISSLFSCLEIFRRGVWMFFRLENEHLNNVGKYRAFKSVPLPFSYYEEEDEEDDKDD
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MCAASFVFLMATIASAGALLDDHVRELASLRAASSYGVIELQDSSLESLILERSGLGPGFYILFFDSSAASGRDEFFQSEFSSLAYSFLKNHAGSTSIFFASMQASKSPPVALHRFNVTGFHIPCVLYLPPSGGGIEVLPRSSTAQQLALTIRSKSGIEIGEIFSPPLSTGKRIALACTAVILACLSPAALKAPFLQDPKIWCGAAITLYIFVISGGIFSILYQVPLIHPRSGHAFHREPDGQFGAEGILVASLYAVPSVAISVIVHWLPRFPSRVMPALAIMGVASCCALGCLSRLHEWKTRRS
The following text describes a protein:
Function:
The different products prevent the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. They inhibit IFN-alpha/beta induced tyrosine phosphorylation of STAT1 and STAT2. Blocking the IFN-alpha/beta pathway requires binding to STAT1 in the cytoplasm. They inhibit IFN-gamma induced serine phosphorylation of STAT1. Block the IFN-gamma pathway by binding to and stabilizing the parallel form of the STAT1 dimer, further inducing high-molecular-weight complex formation and inhibition of transcription by IFN-gamma. May also have a role in preventing the cell to enter apoptosis. Modulate regulation of viral transcription and replication. Overexpression inhibits the viral RNA polymerase. The absence of all C', C and Y1 proteins leads to viral delayed growth. Plays an important role in virion particles release. Modulates virion shape.
Miscellaneous:
MISCELLANEOUS: The C protein is found in virion at a ratio of approximately 40 molecules per virion, presumably associated with the nucleocapsid; MISCELLANEOUS: The P/V/C gene has two overlapping open reading frames. One encodes the P/V/W proteins and the other the C/Y proteins; MISCELLANEOUS: [Isoform C']: The initiator methionine is coded by an unusual start codon ACG; MISCELLANEOUS: [Isoform C]: Most abundant isoform in infected cells.
Subcellular Localization:
Host cytoplasm. Note=Protein C' seems to localize around the Golgi.
Domain:
The disordered region at the N-terminus is involved in C protein self-degradation in trans. This self-degradation of C protein may play a role in the regulation of viral RNA synthesis. The disordered region at the N-terminus is also involved in the host STAT1 degradation in order to counteract the host innate antiviral response.
Sequence:
MASATLPAWIKMPSFLKKILKLRGRRQEDESRSRMLSDSSTQSYQVNQLTSEGTEAGSTIPSTPSKGQALPTESKVRAREKSRHRRPKIIDQVRRVESLGEQASQRQKHMLETLINKIYTGPLGEELVQTLYLRIWAMEETPESLKILQMREDIRDQVLKMKTERWLRTLIRGEKTKLKDFQKRYEEVHPYLMKEKVEQIIMEEAWSLAAHIVQE
The following text describes a protein:
Function:
Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits strong humoral immune responses in both HIV-negative (HIV-) and HIV-positive (HIV+) tuberculosis (TB) patients. Also elicits pro-inflammatory cytokine and chemokine responses from macrophages and pulmonary epithelial cells. May participate in the progression of active tuberculosis both by contributing to the utilization of lipid substrates for bacterial growth and replication, and by modulating immune responses.
Subcellular Localization:
Cell surface. Secreted, cell wall. Secreted, capsule. Note=Cell surface protein that is present in both the cell wall and the capsule.
Sequence:
MNQRRAAGSTGVAYIRWLLRARPADYMLALSVAGGSLPVVGKHLKPLGGVTAIGVWGARHASDFLSATAKDLLTPGINEVRRRDRASTQEVSVAALRGIVSPDDLAVEWPAPERTPPVCGALRHRRYVHRRRVLYGDDPAQLLDVWRRKDMPTKPAPVLIFVPGGAWVHGSRAIQGYAVLSRLAAQGWVCLSIDYRVAPHHRWPRHILDVKTAIAWARANVDKFGGDRNFIAVAGCSAGGHLSALAGLTANDPQYQAELPEGSDTSVDAVVGIYGRYDWEDRSTPERARFVDFLERVVVQRTIDRHPEVFRDASPIQRVTRNAPPFLVIHGSRDCVIPVEQARSFVERLRAVSRSQVGYLELPGAGHGFDLLDGARTGPTAHAIALFLNQVHRSRAQFAKEVI
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAFFLIRLALVAGAVYGTQELGIWESSDHTKVLFEGAKREVSPYAEDLMNRFCCWRCDKCKEDVQVKPWQESMVDAWNETIKKTFHALGVQVPFYYKRFSEDFQQGIDDLVNEKEEIDTNAKKGPKKIK
The following text describes a protein:
Function:
May act as a carbohydrate transporter.
Sequence:
MKRTHTHTPILFHKYSAQKFKNSTPPLPLPVFHFDIQEMATATATGLLLVVLLLFAATPAPSLAELFVVGGKKHRWAPNNINYTGWADQQQFHVGDWLEFRYEKGKYDVVQVNETAYAACDASSPILSHSRGHNFVFRLNHTGRLYFICSRGYCWNGMKFSVLVQQPAVAPAPHASSASAAAAPGVWSAALAASLGWGWAVVRPLPFRV
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MFSSSQPTQSLSRHSQPSANNDISMDAERQGQTPVQTLYLKPEAYPRGGKEKWKATGRTISAAAGPVGGELAVWVTKRPSDDPNKPAKLTNADPTVSDEAIIFASINSLPQPLIQLYTESHLLFTSLQQIVADSGRRRLSSVGFGVNGGAESWDTKGNFGVEGLLGPPDAETVINMRRLADFYVDQLGDLKALPDIDAGLRDRFIDAYNIFNIAEILYLPIDGKGEGLVGEELLDWVNEIDVAPDNQLGNEIMSTLHSWDHPSFWPYISRSILRGFHLPAASFLRSLSSHPYAPISKLAVLLAQHLTILPRSSETKWRIDMDFLQAHKQWLAKFKSELATQLGGKGEGKWFEGEWVNWEGDFRCVVELMEGKMERVLEEAGDWREALGAWGILVDVDMRRDHLPEVMSIITERIPVDKSLPDHVVQSALCSADIIKALMSCYSLDTWLSAHLADLLDKLSLIPDDEEHFEISLRDFFLLEYAQVLQDNPNYKAFWRVICDYLGYAGEEGRGRLKEHLKRLDIPLDRDVKGKSKESPDSTNDEQQGLDASMDIENPTESQGEAIKLLDEVRSACVDFRLDDVWQEISQVLATRLISAGQYGMAATLALMARDGFALSKIADKVLESFITHGQDEYLALVDTLPPTLLAEAPTALLHLQQSTSNPTEFPSHSAVSVFASRITFLSEFRDYLLFLSQDARDRAAEKVISLLTSGIAPVGFWAVLLVESIALLEDSEILFSSNETFELLRVLEEVYANAAFAEEEYLGQLVQYLQRTLNTPAAEEEGHIIKKNEKKVTVKDAKRRMEEVRLAISRNLARAMVAGFDSPF
The following text describes a protein:
Function:
Essential for maintaining proper cardiac intercalated disk (ICD) structure and function as well as cardiac conduction velocity in the heart. Its association with SCN1B is required for stabilizing the perinexus in the ICD and for localization of GJA1 and SCN5A to the ICD. May regulate the function of the gap junction protein GJA1 and may contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein. Note=Localizes at the intercalated disk in the ventricular tissue.
Sequence:
MSRLLPLLRSRTARSLRPGPAAAAAPRPPSWCCCGRGLLALAPPGGLPGGPRRLGTHPKKEPMEALNTAQGARDFIYSLHSTERSCLLKELHRFESIAIAQEKLEAPPPTPGQLRYVFIHNAIPFIGFGFLDNAIMIVAGTHIEMSIGIILGISTMAAAALGNLVSDLAGLGLAGYVEALASRLGLSIPDLTPKQVDMWQTRLSTHLGKAVGVTIGCILGMFPLIFFGGGEEDEKLETKS
The following text describes a protein:
Function:
Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSIEANTFKILICSDTHLGAGEKSHCLKDDCYLAFEEILQQANQEDVDLILHSGDFFDDQNPSKYCLTKTMELMRKYLMGKPKNSFDVAYTYEHNQEDNGFSMNQGIKYPMYVIHGNHDIPSGIEHVAGLDILQTAGLVNFIGKAEDISEIDNKTDQTILHLSPILLQKGTTRIALYGMSYKKNEEMNRLWASSQVQIDEPDGDVFKILLIHQDRILRNTLTTFPEELLKDRFNLIVFGHEHCSQVEEGTDVQIIQTGSSFPLSICEFEKAEKFIGLAHINGMKINMNKIALRNVREVFYEVVQMSQMIEGSANLEMVEHYIREEVQNFFDHVNTHSKTMLPLARIIIEYKSLGCIPNLRKMAFEFEKNIVNKGDCIKLKKKIQKREKKSNKKIVDDDLYDVFFDEDFMDEDFLARRRAAQIEAYIAEEMKLKTPKTIPLKAIEKVIEQVGNNQENDYAISTIIQCYINKNIEQAMTIIQHDHSKKMNEVIEEAFQYVETLTLDEDDYDYVERKMAEEKGKKKSTKKKVSKKTNSKKKKTQQKVVDVDEENLLSENSDDDVKEIKKPIFKKITKKNKKATKDTLILKKLKGTDQF
The following text describes a protein:
Function:
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Subcellular Localization:
Nucleus.
Sequence:
MSDAVVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNANEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDDREE
The following text describes a protein:
Function:
Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
METAPKPGRGVPPKRDKPQAKRKKPRRYWEEETTPAAVATSPGPPRKKARTGESRPPRSKSAHIAQKSRFSKKPPISKTAPDWKKPQRTLSGAQDPFPGPVPAPLEEARKFCRIDKSKTLPHSKPKTQSKLEKAEAQEEEASVRAARAELLLAEEPGFLVGEDGEDTAKILQTDIVEAVDIASAAKHFDLNLRQFGPYRLNYSRTGRHLALGGRRGHVAALDWVTKKLMCEINVMEAVRDIHFLHSEALLAVAQNRWLYIYDNQGIELHCIRRCDRVTRLEFLPFHFLLATTSETGFLTYLDVSVGKIVTALNVRAGRLSVMAQNPYNAVIHLGHSNGTVSLWSPAVKEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLRGTFQPLSSRTLPQGAGHLAFSQRGLLVAGMGDVVNIWAGQGKASPPSLEQPYLTHRLSGHVHGLQFCPFEDVLGVGHSGGFTSMLVPGAAEPNFDGLENNPYRSRKQRQEWEVKALLEKVPAELICLNPRALAEVDVVTLEQQKKERIERLGYDPDAKAAFQPKAKQKGRSSTASLVKRKKKVMDQEHRDKVRQSLEQQQQKKKQDMAMPPGARPSALDRFVRRAREGGLQVDP
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MHSNNFRIVRREIAKNPPENRHGDDELLDSESSSSQNRTKHKRGMSKRFQQQELEGLINDIEDEWKDLFKENYNPLSTALELLDKSSFGRGYENFIETYDKVKSALQRISSENKEDFMQNVTAYGRIMDRLNVTTSKVLNLKASLKSAQSSIDNITGSSELLQLLSRSAQLNIIIETLQSVHSAFQSRQNIETLIKQKKYYEASQLLVKTSQTLSEKSFEGISSVDGLRSQISAMESSFFETLVDELTRIVFLRSDTTYSLETPKDSPITTNPFFLREFLDSINKEPSIRQVNKLKKIAEILQEPLDKDRYKEHGTDSFRDLRMVLESLNNLNKLRDALAVLKQRTPAEVYYLVDCVVKHADTTYSAGFNCDIPTATQSIFDAMFDSKNEQQSKIFERFFHLFSLKLDTLVFHYRLIGDYLTRLVGTDSMGVSRYEFSYSPLWDALKNELGLLLKDYLITPVEYSYSKQSKAAASDSTIHTNYEFDQNKSFFSSVNGCLPQKDDKSFAAELTKIVKDFSLINVGKSNSNTSTTDLNLYVNQQGSMKFATNHKIIAYPSIFDAPIVLMSVVSLLTNFRYILDGVSNVPQGAYVRVISAFLKDTFLPHFTDIIFSYFDDIMNDPDAFKVHPDWIKFHDYPIYKGFVSTLQFVESLTNSFPVMASNLVEYYEILLKVLRKLESKAVRFVNELCVTTLLKKYKFTKNISDLGTETARLKTVGNEKLFNSFSSLWNSPDQPESEWTELYLTERKGSLFYGRNEEDIENLPKSIISRDSSVASQIAYLYNSLIWFNKKCFYQFHANKTEKENTSENNIQYGRPLFVMRVLDYDNPQHKSLIGDYETVIRSYRDLSYQCLLLLRMEIRLLYFNTLVQIVKVPNFILEYKGRPDDVVIELDSTIISVNFEIERSLPERERAMIWKGLDFIVDHQMYEIFRSLKSMNRGACLQTLRNLAVMVQTLKIVNDNPDAVGLMRSIRAFGVYRLGLKKVTEFFASKPTASNYEDVKHMVSIFYRKMLNEAQAQERDDLVRQYTRKEAAYNAEIDRIAKAASIETHLVKSNESTPKPRK
The following text describes a protein:
Function:
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MIEINEYIKKLGGDKNIEKILIANNGIAAVKAIRSVRKWAYTNFGNERAIKFVVMATPEDMKANAEYIRMADQILQVPGGSNNNNYANVDIIVDFAERAGVQAVWAGWGHASENPRLPDLLSKTETGIVFIGPPAKAMADLGDKIASTIVAQSARVACVPWSGSGLKVDYSECNGVPSEIYGRACINSVEEARECAQRVGFPAMIKASEGGGGKGIRKVTSMEDLESSFRQVQNEVPGSPIFFMKLVSNARHLEVQIVADRHGEAISLNGRDCSVQRRHQKIIEEGPAIAPTPQVWEEMERAAVRLVKEVGYVGAGTVEYLFAEGEYYFLELNPRLQVEHPVTEQITGVNLPATQLQIAMGIPLHRIPDIRKLYGRTGDDLYGDSMIDLHDFTKRNPPAGHCIAVRITGENPDEGFKPTSGQIHELTFRSTPNIWGYFSVGAKGGLHEYADSQFGHIFANGATREEARKTIILGLKEISIRGDIRTPVEYIIHLLESKDFKENHIHTGWLDQLISEKIQTKKPETMIVVLCGAIYKASTIFSTKIQEFSNQLSNGQLPSLELLNNSLPIELIYNNVKYQFEVSRTGINNYSVCLKNDKSAVSIDSSVIMLSDSGLLILLNGSTHVCYGREDVIGLSLMIDSKTCVFSQEYDPSILRTSSPGKLVRYLVDDGSLVVKGTPFAEIEVMKMYMPLLVPEKGIIKFVLTEGSVMAPGAIIANLELSDQSSIQKSTVFTGSLTKMSPPTLIGNKPHQLLNYTLGKISNVLCGYESNDLNQLLNDTIKQLSNQKLPLFEFKEQLSIVQSRIPQSLFKLINDELNKFEFNNDDDDEDDSELFNSKNLQLSISLYLNKLLLENEQLSIAIQLLIKPIILLAEKYNDGVSFAAINIFKNYLEEFIQIETNLQNKNIQTVLKSIRPTYKDNISKVVDIAQSLHPQSKKYKFILLLLNKIQEQGLVCDFVEQFKKLSSLGGNCMEISLKAKHIMVHSQLPSNKQRSNDLINSLKSILNVNNEQQQQVDEKVQDNKDEKISKLSKQTNEISDILIPMFFNESNNDDDIRKLAMEVYVRHSYRSYYVEDTKVTLSNDEGSSGFSFIEWHFYINLPQQSNLGGSNSGSPTYGSPLIRSISSSGGSSGGSGFQISPRPSMSIFNGLSMLRTDSTDSLTAMEDQTKLRYGMMVFFENEKKFEEKLPLILTRYNEENNKKSQLSLSPNESTDILSVIISIYPESISQENQAISSFQSILKGYIKELSIARIRRITFICCGGDEGKPLKYFTFRERHMYMEDPIFRHIEPAMAYHLEVRKLSNFDITHVPTTSQRIHLYYAQEKGKKETDPDADRSFFVRSVIRYSDLYGHSNEIKVDILLSQIETLLSESIESLEIAMSNKKYEKAQNHSIFLNVMPEVMFDEKMIGYVVQEIGDRLGKRLWKLRVGRVEVRGRIRKGDGLIPVRFFVQNPTGYAFQVQCYYEQQNSIGQMVFAVVPGSSKGSWEGLPVDTPYPIMDAVQRNRFKAQRLDTTYCYDYPDLFREAMQNIWMEFMESNKTNPVKVYPSSRGVLESVELILPSTINTDFPPSIPLDQLPEESKPKLEETYRPIGYNDIGMVAWRMTFYTPEYPLGRQAIVIANDITHQIGSFGPQEDMLFKLASELARKEKIPRIYLSSNSGARIGLADEIKSKFKVTWNVPSDPTKGIKNLYLTNNDYQALKDSVIAYQDTTDKDKWIIHDIIGQKNGIGVENLSWSGLIAGETSQAYNEIFTITLVSGRSVGIGAYLVRLGQRTIQNDAPIILTGASALNKVLGKEVYESNQQLGGSQIMYPNGVSHIIVNDELRGITNVLQWLSFVPKSGGEMVPIISPIDSPHRDIEFDPSNSINGKCDTRHLIAGLQSELDPNYWISGMFDKDSFMETLAGWANTVITGRARLGGIPVGIIAVETKSVEKIIPADPANPLSYEQVNTQAGQVWYPDSSFKTAQAIADFNNGEELPLMILANWRGFSGGMRDMFDEILKFGSMIVDNLRNYKQPVMVYIPPFAELRGGAWVVLDSTINLDMMEMYCSEEGRGGVLEPNGIAEIKYRDPELIKTMHRLDPKLIEWDKSIPIGVSVNGLDQSQKTIKSQIQQREKELLGIYQQIAIKFADLHDTPGRMKAKGVIKQMVPWKSARSFFYDRIKRRLFEEDKLKLIDKSHPGLNRQSKLNLLETWIKQILGNNQSVDYHQNDKLISSTIESNSHIINDKIIDLSKQYAINQILNFVQSDSESIVDGFQNLLPFISTQQKEFLFESLKKDLNK
The following text describes a protein:
Function:
Probably a 5'-3' DNA helicase.
Sequence:
MDYENQIANIFSLNGELSQNIKGFRPRAEQLEMAYAVGKAIQNKSSLVIEAGTGTGKTFAYLAPALVFGKKTIISTGSKNLQDQLFNRDLPAIKKALNFTGKIALLKGRANYLCLERLDQVIAQGVLGDKSVLAELSKVRKWNNSTKTGDFTECIELAEDSPIIPQLTSTAESCLGTDCPNYSECYVASARKKALNADLVVVNHHLFFADMAVKESGFGELIPNAEVIIFDEAHQLPDIASQYFGQSLTSRQLFDLCKDINIVYRTELKDMQQLGTTSDTLLKVVQDFRLLLGNGSNVRGNWRELYTQSAVKKAFELLQEKIDFLSEVIKLALGRSQTLDSIFERVESIKIQLKRLSETNIVGYCYWYEGNGRQFGLHITPLTVADKFGAQLEAKEAAWIFTSATLEVGGTFNHFCQRLGIENATQKILYSPFNYPEQSLLCVPRYLPNTNQMNTLNSLGEILLPVIEANKGRCFVLCTSYSMMRGLAEYFREKSHLSILLQGETSKGKLLEQFIKETHSVLVATSSFWEGVDVRGDALSLVIIDKLPFTAPDEPLLKARIEDCRLQGGDPFNDIQIPEAVITLKQGVGRLIRDVTDRGVVIICDNRLVMRNYGETFLKSLPNSSRTRDLNKVIQFLQNK
The following text describes a protein:
Function:
Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
Subcellular Localization:
Host nucleus. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus.
Sequence:
MSAPVVIKALVASNTDIAEAILDAILSRPDEGFRLFCLCHNASPLHHVAGSLVELQLHLPKKRLTSQSRCGLVLTLHLPAEEAFPFLRGLTPLTADRLSTYLDRAGALRSLTPLVELLTLSAKKQPQGDARGRVAWLRPKIVGCLRRIYRVNISARWFISTFGSHEAQFVLVTAAYYFWGIPCTIETLAHLTELFTSESGQSLAAVTSLAELGEVFGSSAWAEQTEAFAHFAHEKLRRDSREIRAVARTIDAYRGRLPLASADLVRYVYLAHAQCFNEGTFKRYSQLTSMGEIGCLPSGGVVLPSLLDRGFAEHMRTYFTRETYLAEHVRVQQLKIRMEPPAPYTWDPDPDDGLMRAWAGLSVDVARELVELARWHADEGPTYPPTLQGFLCLAGQATCRGQWNPKEQFLPPTVLRRVQRLPVFLCHFADRHYFVMTAADPFSSHLAEVVSTPTNCRLPDTCLTRALSYTPVYYSQNSLSEQLFVSRHEYFNPRLPVCNLVLDLDLKIKGAPWSLEEIYDLCRTVRREVLRLMRRLGPVSRAHPVYFFKSACPPADPDNMEDVLPFCICTGKLGFRVITPLPRGHAIVGTSAVQGFVSVLQKLMGLTACLRRMRHKIKEIGAPLFDSGVYHAGRCIRLPHTYKVDRGGGLSRQLRLFVCHPEEEDKHSYVKNALNIQNLLHHSLHVGWPAPKTFCYHIADDGRDYLIQRTRETLPPTVENVCAMIEGHLGLDLVAWVSSCIWPSLMSTLATAVPEDKFPQFLHVTFEQTGPNLVQVCHARGRNFACLRHTHRASSKNVRVFLVLYYTSQAITVTFMSQCFAGRCGANQPTAHFSISVPASRIINRAEASQDSTTSQLARRRDRQDGSFSETLPN
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Sequence:
MAAAATMVSSAGGLLAMLNESHPALKLHALSNLNTYVDYFWPEISTSVPIIESLYEDEEFEQRQLAALLVSKVFYYLGELNDSLSYALGAGPQFDVSEDSDYVHTLLAKAIDEYASLKTKAAESNDASAVVDPRLEAIVERMLDKCISDGKFQQAIGMAIECRRLDKLEEAVIRSDNVHATINYCIDVSHSFVNRREYRLEVLRLLVKVYQQLPSPDFLSVCQRLMFLDEPEAVANILEQLLRSEDVDEALLAFQIAFDLVENEHQAFLLKVRDGLPSAKLQPSEPAVPSGSAQPEPAQSGNAVTSEDVQMTDGAQVDGSAITSDPLEVIYAERLTKIRGVLSGETSIRLALQFLYSHNKSDLLILKTIKQSVEMRNSVCHSATIYANAIMHAGTTVDTFLRENLDWLSRATNWAKFSATAGLGVIHKGHLQQGRSLMAPYLPQGGSGGGGSPYSEGGALYALGLIHANHGEGIKQFLRESLRSSNVEVIQHGACLGLGLAALGTADDEIFDEIKNVLYTDSAVAGEAAGISMGLLMVGTASEKASEMLAYAHETQHEKIIRGLALGIALTVYGREEEADTLIEQMTRDQDPILRYGGMYAIALAYRGTANNKAIRQLLHFAVSDVSDDVRRTAVLALGFVLYSEPEQTPRIVSLLSESYNPHVRYGAAMAVGISCAGTGLSEAISLLEPLTSDVVDFVRQGALIAMAMVMVQISEASDSRVGAFRRQLEKIILDKHEDTMSKMGAILASGILDAGGRNVTIKLLSKTKHDKMTAVVGLAVFTQFWYWYPLIYFVSLAFSPTALIGLNYDLKVPKFEFLSHAKPSLFEYPKPTTVPTTASAVKLPTAVLSTSVRAKARATKKEAEKASTEKAEPNSAKGKTVDKDGDSSMQVESTVEKKAEPEATFEILTNPARVVPAQEKFVKFLEDSRYVPVKSSPSGFVLLKDLRPNEAEVLALTDSLSSTSANAGAPPAAGQQQGAASSMAVDEEPAPPQPFEYTS
The following text describes a protein:
Function:
E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3. Plays a role in adenovirus-mediated cell lysis.
Subcellular Localization:
Cytoplasm.
Sequence:
MCFSFSISVVLHVLGSSEHRMQLVVQPGHPAKFGRFVLLMSEIIALAFVLKNSQAKDLGDGYLSKTHFQVTNKSISPDLKKENGSTEQTLLTHVEESSDDSQVAGVCATEEVIRYEYHVLYSSSYQVPVLYFRACFLDGRPLTLDEIWKSVHVCYQARLQEGPWDTITQQEHPLLGQPFFVLHPCRTNEFMCSILAGSQKDNRHRNYIVLWLSTVGPVVGLTLPLSYAKLEPEENTNAEID
The following text describes a protein:
Function:
Probably a pantothenic acid-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKSKASDVAILAIFIAIMVVVQLFTQFVINVWPFPVKPTLLHLPVIIGSIILGWRKGAFLGLVWGLISFVTATIVTTPTSFLFSPFQPVIGTHHGSPWGLFIAFIPRILVGILPYFVYKIANNRLGAGLAAFAGTATNTVLVLTSIFLFFGSTLKWSLSYLLGAIVATNSLTEVIIAVILTTAIVPALTKARNNS
The following text describes a protein:
Function:
Catalyzes the attachment of lysine to tRNA(Lys) in the mitochondrion.
Miscellaneous:
MISCELLANEOUS: Present with 2280 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MNVLLKRRSLTFAPRWLWCKCRSSRSRPYSLAHAVDTSKMEATRRNGQIVKDLGRYYPSMSESALHDLCQEYKEVTIADFNERFLGNPATLHHEDNPNLLLSINGRIKSIRFSGQKIVFIDLYNGSSGLKNDTQLQLIVNYNKIGGSSEDKANFSEYMNFLKKGDYIKALGYPGFSQSRVKMLSLICNKLPIVLSVSQLPLPSRLNDETKIKSNRVVDYQLNGTQTLLVRARIIKLLRKFLDDRNFVEVETPILSSKSNGAMAKPFITSSKDFDHLELRIAPELWLKRLIISGLQKVYEIGKVFRNEGIDSTHNAEFSTLEFYETYMSMDDIVTRTEDLFKFLITNLQKFFQDTRLPVPKTFSELHLALSENNWKFRKVEFLPTLNKELGIDLMNSGLDINKPSELLKALPKDIAKKYFPSADNTGQLSSLQILNKLSDVFLEQRHCQSTLPTVIYHQPAILSPLAKTDPQNKQVTKRFEVFIKGKEYINAYEEENCPQLQLQKFLQQKQINELTGNKTETLSPVIDYQYVETMKYGMPPVGGFGLGIDRLCMLFCDKKRIEEVLPFGCVDDVNRQ