lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Diguanylate cyclase (DGC) that catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V.cholerae, and is proposed to play an important role in the transition from persistence in the environment to survival in the host. Overexpression of vdcA results in increased biofilm formation, and reduced motility and virulence.
Sequence:
MMTTEDFKKSTANLKKVVPLMMKHHVAATPVNYALWYTYVDQAIPQLNAEMDSVLKNFGLCPPASGEHLYQQYIATKAETNINQLRANVEVLLGEISSSMSDTLSDTSSFANVIDKSFKDLERVEQDNLSIEEVMTVIRRLVSDSKDIRHSTNFLNNQLNAATLEISRLKEQLAKVQKDALFDSLSGLYNRRAFDGDMFTLIHAGQQVSLIMLDIDHFKALNDNYGHLFGDQIIRAIAKRLQSLCRDGVTAYRYGGEEFALIAPHKSLRIARQFAESVRRSIEKLTVKDRRSGQSVGSITASFGVVEKIEGDSLESLIGRADGLLYEAKNLGRNRVMPL
The following text describes a protein:
Function:
Catalyzes the formation of short polymers of R-3-hydroxybutyrate (cPHB). Involved in natural transformation. Probably part of the ABC transporter complex YdcSTUV. During natural transformation, may bind dsDNA and convey it to the inner membrane channel formed by YdcV (Probable).
Subcellular Localization:
Periplasm.
Sequence:
MSKTFARSSLCALSMTIMTAHAAEPPTNLDKPEGRLDIIAWPGYIERGQTDKQYDWVTQFEKETGCAVNVKTAATSDEMVSLMTKGGYDLVTASGDASLRLIMGKRVQPINTALIPNWKTLDPRVVKGDWFNVGGKVYGTPYQWGPNLLMYNTKTFPTPPDSWQVVFVEQNLPDGKSNKGRVQAYDGPIYIADAALFVKATQPQLGISDPYQLTEEQYQAVLKVLRAQHSLIHRYWHDTTVQMSDFKNEGVVASSAWPYQANALKAEGQPVATVFPKEGVTGWADTTMLHSEAKHPVCAYKWMNWSLTPKVQGDVAAWFGSLPVVPEGCKASPLLGEKGCETNGFNYFDKIAFWKTPIAEGGKFVPYSRWTQDYIAIMGGR
The following text describes a protein:
Function:
Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation (By similarity). Required for several aspects of morphogenesis of C.elegans, including regulation of division in the germline and gut and specification of ventral-uterine precursor cell fate.
Subcellular Localization:
Nucleus.
Sequence:
MDFIDNQAEESDASSGHSDDEEPQSKKMKMAKEKSKRKKKMVASSDEDEDDDDDEEENRKEMQGFIADDDDEEEDAKSEKSEKSRHSGEDELDDEDLDLINENYDIRETKKQNRVQLGDSSDEDEPIRRPNHEDDDLLSERGSDDGDRRKDRGRGDRGGYGSESERSEDDFIEDDGDAPRRHRKRHRGDENLPEGAEDDARDVFGVEDFNLDEFYDDDDGEDGLEDEEEEIIEDDGEGGEIKIRRKKDTTKKSTLLESIEPSEIDRGFLLPGDKKIAKEDLPERFQLRRTPVTEADDDELESEALWIIKYAFEEGTVTNQADLDQDDKLDCIMNLDPSVYEDRKKAVIKSIKKVLQFIRVRSNSFEPTFIGFYRKEDIDNLLTMNNLWRVYDFDEKWCHLSEKKNKIYDLMRRMREYQELSDDLTAKRRPISDADLMDTKYAETLEQLTDIHANFQLLYGALLDDMIRWEKGRLTGEEEEQEYRVKFKSSIRNDKYQMCVENGIGELAGRFGLTAKQFSENLNWKKHDIEQDPMLPLEAAEEYVCPAFSDSDMVLNGAKFMLAKEISRQPQVRHSVRQEFRQSAHFWIKPTKKGRDTIDQTHPLYDKRYIKSKPVRSLTAEEFLFYHKAKEDGLVDVLIMYESEEDQDSNNYLVNKYLSDSIFQKDEYTENVEQWNSVRDECVNMAITEMLVPYMRDELYNTILEEAKTAVAKKCRKEFASRISRSGYLPDFDNNDDDDDGMDQHGARRIMAVCYPTERDEASFGVMVDENGAIVDYLRMVHFTKRTFGGGNNGLRKAESMDLFKKFVQRRKPHAIGLNIEDMECTRLKRDLEEAVADLFSQNLIYKPIPVFLMDNEAAKVYMRSNVSLAENPDHPPTLRQALSLARLLLDPIPEYAHLWNIDEDIFCLSLHPLQRDIDQEQLALVLSHELVNKVNEEGVDINKCAEFPHYTNMLQFTCGLGPRKATDLLKSIKANDNLIESRSKLVVGCKLGPKVFMNCAGFIKIDTIKVSEKTDAYVEVLDGSRVHPETYEWARKMAVDALEVDDSADPTAALQEIMESPDRLRDLDLDAFADELSRQGFGEKKSTLYDISSELSARYKDLRQPFQEPTGELLYDLLARSGKEIREGAKVLGTVQSVQYRKVDKDAADSMLPDVGEDGLFTCPCCKSFTSSAPGGIQEHMLGDSRQGGCPGTPVGIRVRFDNGMTGFCPNKNISSSHVDNPLTRVKINQPYYFKVLKLDKERFSLFLSCKSSDLKEDDLSQRDQYWDEHQYQADLELMKSESKKKTEANTRVKRVIAHPNFHNVSYEAATKMLDEMDWSECIIRPSANKDSGLSVTWKICDRVYHNFFVKESAKDQVFSIGRQLSVGGEDFEDLDELIARFVQPMIQISHEITTHKYFFPNGTCEETEAVEQFVREKKRELGRSPYVFSASYRQPCQFCISYMFDNTERIRHEYFKIVPHGVRFRHQNFDTLDRMMAWFKRHFHEPPIELRRSAIPAPQYRVGAPPAAPYYPPQFVGYH
The following text describes a protein:
Function:
Required for cytoplasm to vacuole transport (Cvt) vesicle formation and efficient autophagy. Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9. Also plays a role in regulation of filamentous growth.
Miscellaneous:
MISCELLANEOUS: Present with 538 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Membrane; Peripheral membrane protein. Note=Found in pre-autophagosomal structure and other punctate structures. Correct localization of ATG23 to the membranes is strictly dependent of ATG9. Cycling through the pre-autophagosomal structure and correct location to other punctate structures is ATG1- and ATG13-dependent.
Sequence:
MELNQVLEKKEQILQYLGTLVGLHEKALSDVNSASQVTSIRKDITICLNDLCRINDLLVSHDGLLKREIGSLLRDKQELLELNEREQLLWKERKSWHIKQETDAAPADYVIDKDAIITISSHHRTSLNKYIESVGAENTILSNTDDSDAMIEEVQNAESSADQMIRNYKLLQLSHKQAKSEIIRLETLLRDFKKDNKFIEEELKRQSGRIRSEMGNIDFHLSKIEESKHQLMKRIGFESPLTQEKSLSEKIFNLRLSSADEDYNERQTINMKNFVHMKDLIELKIEDLQEQLMRNKNESSTVLTQRELWLDCQKKVGDLESKLITKLRSSSNSKIPPNEMSEMINSTIQYLNNLLDSSDEKLTTTLISNERDVLSKACEELHSESTTAQDGSSALPSKPIDIHKSHKGSNASSNLKQPSTPSFLVASKSPPKIGISESVVNANKNDAISKKVE
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase. PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Domain:
The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex.
Sequence:
MVDNYNNNNILPTNTSTTTTTNTTITPTPPLPPPPPISNILDNNNNNNLIKNDIKNDKVAVSNSNVRPSSSSVSYENSDWNKVYNSEREKLHEVNKQILNIKRPSTSIVRVSQLDSARLDEEILDLLRSQFMKIFTFFKPNFIHNFQPEINLVLKSVIYKLSIFNLGTTYGNQLQNLTYRNEKAFDPIRGSDQLNKLTMRQKWLSGLINIGGEWLWTRINRYLINNNWSEHPPNDIRKKFWNFLNFAESAYKALALLNFLTFLFNGKYVTLVNRILHMRLVYAHPTLSRNISFEYMNRLLVWHGFTEFILFIMPLINIDRIKSFLYRLLVKTSFGNSSGNNNNTASNPLQQLQKQQLLIQQQQMALAKCPICMNDPISMPYSADCGHLFCYYCIKTSCMIDSSFTCPRCNSLISNIKRFSIQD
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Sequence:
MMRLICCPRAATSAAGFSALARRASPFCRRKAKKAQVHALSEMCGFPIGSVDSFVEKLVMHHGVKVAICNQVESASSAKKRGYNALVDRQVVRIVTPGSLVEDTMLTPKENNYLGSLFYDDEKWGLAWADLSTGEFVSTTSTSEKLASAILRCSPKEILLPSFPVENGVATGHRSRGSFIKTLDAPEQAAVSAILDYVDFTHRGVESSDHMIIDSSAWRGLELAKSLNGSKASSLLQAIDSTTTPGGARLLAAHLASPLMNLELLECRLDAVSYFYGQEQLLQRTRKQLAERLSIGVATPKDLKNVASTIDEAKRLVALDCCSGLIATEQQREDIANAAEEIYAALKDDYASLNSKSGFAEKGYFLDLSHDENAKLLKTDRGRSELEKLTLFQSLKNSVRYRSEELRQLNRELTEAVAEVERVENDIFASLRDRVLLVRDELQSMAHAISQIDVVCSHAQVALDRNFTRPLLDGSRELHIEDGRHAVVEAAHLRGSNSRSMRAFVPNSLHLAAAPIGSCWLLTGPNMGGKSTFLRQSAHLVVLAQMGSFVPAKFARVGLVDKLFCRVGSADDLAADKSTFMVEMQETSTILTQATSRSLVLMDEVGRGTAVNDGVAIAGAVLEALCAKQTRMLFATHFTALSDLVGDTCHGELRPYRMEVLEHHVDGQPKQLVFSHRVVEGLAAQSYGVNTAALAGCPPAVVARATELLRQLTHNNDEDSDDRLMDTNEAAHRLQRALSILGQQDAYPTKSPIFLRDTESQAKVVLLHRVADEVVVIQSVDDEQELIVGANGGCYFESPLLGISEEFKVDVLANGSMVFVSCRTGNALDCDGNGFPQCIDTIRRGWFLLQREVTTIPMKSPVEETAPVSSPVCGHCKDHEAKERREYIMKLVSLGKSLDEIDSILLWIELGE
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway. Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2. Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway. Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies.
Domain:
The RING finger domain and the coiled-coil region are required for the apoptosis-inducing activity.
Sequence:
MEPGPSVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRRCVSGCWEVQTTPSCPVCKERAVPGELRTNHTLNNLVETLLREEAEGARWTGRRSPRPCRAHRAPLTLFCVEDKELLCCACQADARHQEHRVQPIKDTAQDFRAKCKNMEHVLREKAKSFWALRRTYEAIAKHNEVQTTWLEGRIRDEFDKLRDFLRVEEQATVDAMKEESRKKHLLAEEKMKQLAEQTEALAREIERLQMEMKEDDMTFLMKHKSRKRRLFCTVEPAPLQPGLLMDACKYLESLQYRVWKKMLGSVESVPFSLDPNTAAGWLKVADDLTSVINHGYRVQVENPERFSSAPCLLGSQVFSKGSHSWEVDVGGLPSWRVGVVRVQAHAQAQAQADVGGEGHSHSCYHDTRSGFWYLCRTQGVDGDHCMTSDTATAPLVQAMPRRLRVELECEEGELSFYDSERHCHLYTFHAHFGEVRPYFYLGASRGDGPPEPLRICHLRVSIKEELDI
The following text describes a protein:
Function:
Client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly. Acts as a bridge between NOP58 and the R2TP complex via RUVBL1:RUVBL2.
Subcellular Localization:
Nucleus.
Sequence:
MEFQGERGTGPGVSSSSVACSQVTVSRELLTAGSEGSGGIWDQLLISSKPHPRKTSTLQTVRMQRSPLLDQVQAFLPQMAQANEKLRREMAAAPAGHFNIENIDETSGNIIQMDVALFEMSRSDSKEEDSPEESSRDSSGDSSESEEDVCVPSEVTIENIKLPNAEGGKGKIEILDSPASKKKKQ
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
MTNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKGMPHECYHGKTGRVYNVTQHAVGIIVNKQVKGKILAKRINVQIEHIKHSKSRDSFLKRVKENDQKKKEAKEKGTWVQLKRQPWPPREAHFVRTNGKEPELLEPIQYQFMA
The following text describes a protein:
Function:
Involved in nuclear mRNA splicing.
Miscellaneous:
MISCELLANEOUS: Present with 736 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MNYNLSKYPDDVSRLFKPRPPLSYKRPTDYPYAKRQTNPNITGVANLLSTSLKHYMEEFPEGSPNNHLQRYEDIKLSKIKNAQLLDRRLQNWNPNVDPHIKDTDPYRTIFIGRLPYDLDEIELQKYFVKFGEIEKIRIVKDKITQKSKGYAFIVFKDPISSKMAFKEIGVHRGIQIKDRICIVDIERGRTVKYFKPRRLGGGLGGRGYSNRDSRLPGRFASASTSNPAERNYAPRLPRRETSSSAYSADRYGSSTLDARYRGNRPLLSAATPTAAVTSVYKSRNSRTRESQPAPKEAPDY
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol.
Sequence:
MSQRKIQKVMVQPVNLIFRYLQNRTRVQIWLYEDVTHRLEGYIIGFDEFMNVVFDEAEEVNMKTKGRNKIGRILLKGDNITLIHAAAQEA
The following text describes a protein:
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.
Sequence:
MKPRNGPTKRKNNVRSKREKRDDDVMNTNDSSIVSKRCVSKLYFSNEPDYYEPFAPKYVRRNPLINRGYWLRMHAIEQAVLRFLEKDNGKPKVVVNLGDPLPFQFWHRYPALTKHVTFVDVDYPQLMERKRDRMLTNGLLRDALLKTQVRSSELPVYLRSDRYMAIGCDLRHLGLLEKTLRAELDVPSSSVLFVAEVSATYMPVADSDALIRWASTLEDDHPFAKTMLAHFKKLQASIHAIERYLPLQQHSSRFTESGWPSLEIARNLWDLWSDDSFTPPAVRRQLDLIEPFDEWEEFALYGGHYFLLVASNAELRNSTETSGTGVTTNHDEKTNGAEEINLLHIESPADDQLTPRRFASVFRLDAAGVAIHGGQGQRTRLSSVDVLTQDNKALKFQPSFSQGPSARMCHTVTSIDDRQALLVGGRGSPTQAFNDCWLTRDGVWTKVDDLATARYRHSSVPVRSESDVSEVIGVLVFGGKTSDGTALADWTFWTANNGWHSIPVDGDGPHPSPRFGAAMSMMGTGITSGLLVGGMCQSGTVLQDVWEWTISITPTLRLTFKDRTNDLRGVGSHTTYARIGASLVPWDNSLLLIGGVSKFGIHSLSEDFLLLTPSSAEINIRQPVVPLPSTWPLLVGMGVVAVSRDEFVIAGGGAVCFSMGSFWNDGYLTVTKAGVQGMRMWRKVPLQVDGTAQAKPPGVPHKGQPIKAKKTSGLRTAKVPRIHSESAEAFEKLVAAAKPVIIEGLDIGPCTDLWTLDYLKVKIGVERELVVHECNSDRMTFKDKNFQYVKRTTGEFLDGIAQGTKSYLRAVSSSQPNKLPTKLEDDFPDIAADFKIPEIFDAITPNIHSSPLRISGPVSLWLHYDVLSNILCQIRGTKTLHLYPPSDVKYLDYPPGGSSSNTDVLASKDPKLRFTHPHIASLKPGDILFIPPMWSHTANPDEGVSVAVNVFWRGLDKGYAAGKDVYGNRDLQAYENGRRDVEKIVRAFRDVPSDIAKFYLDRLALEIEEGAGKIGKKGRSADEGAGEGE
The following text describes a protein:
Function:
DNA helicase that plays a role in DNA damage repair and genome stability (By similarity). Exhibits a magnesium- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Plays a role in restoring regressed replication forks (By similarity). Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions (By similarity). May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MASVSALTEELESVASELHAIDIQIQELTERRQELLQRKSVLTGKIKQYLEDSSAEASSDLDTSPAAWNKEDFPWFGKVKDVLQNVFKLQKFRPLQLETINVTMARKDIFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSQLKLIYVTPEKIAKSKMFMSRLEKAYEAGRLTGAAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLMGLTATATNHVLKDVQKILCVGKCLTFTASFNRPNLFYEVRQKPSSAEDFTEDIVKLINGRYKGQSGIIYCFSQKDSEQITISLQKLGIHAGTYHANMEPEDKTKVHTQWSANELQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDSRADCILYYGFGDIFRISSMVVMENVGQQKLYEMVSYCQNVSKCRRVLIAQHFDEVWNADACNKMCDNCCKDVSFEKKNVTQHCRDLIKILKQAEGLNEKLTPLKLIDAWMGKGAAKLRVAGVVAPALPREDLERIVAHALLQQYLKEDYSFTAYATISYLKVGPRACLLSNEAHAVTMQVKKSAQSSVRGALSEARQVEQVDSKGEEQSSGNSQKSKSRLQPSGSKNAGAKKRKLDDA
The following text describes a protein:
Function:
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MQSWQTCALSGELIETPVISKVSGHIYEKRLIEKHIESTGTCPITGRPLNIEDLIEVKVSRVQKPRPVTATSIPSLLSLLQNEWDALLLEQFQLKQHLEQVRHELTHALYQHDAACRVIAKLIKERDQARIELAQLQHKLNHKIEVEANNAPEKLSSNYVAEIEENALKLTNQRKVQRKQQSYFDQFPGPEILSTYDVKQQYQQTQGGTTLDTQGNYVVVGGLAGQVQLYSQEKLVYQVSEHTQNITSVNFFTYDEHIRFVSASLDGNLKIYQFNSQTQEGQVAQTINIGSSITGVAIHPIGYIAIIVTNNGLLAYYNLKSGQQLSRVTDFEGQCQFTCVTVHPDGLLLAIGQADSQIKVWNIVKSQQLAQFEGQNGAVTNLSFSESGANLASSSSTEVNEWDLRKPGQFQKIHQDQKIGAISYDPSGQFLAIGSNKTIHFFDVKKKQEFFNIESHRDVVTSIRFGQLSKYIYSCSVDKIVNIYGN
The following text describes a protein:
Function:
Mediates the transport of the dicarboxylates fumarate, malate, and succinate across the cytoplasmic membrane via a Na(+)-electrochemical gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAYFNQHQSMISKRYLTFFSKSKKKKPFSAGQLIGLILGPLLFLLTLLFFHPQDLPWKGVYVLAITLWIATWWITEAIPIAATSLLPIVLLPLGHILTPEQVSSEYGNDIIFLFLGGFILAIAMERWNLHTRVALTIINLIGASTSKILLGFMVATGFLSMFVSNTAAVMIMIPIGLAIIKEAHDLQEANTNQTSIQKFEKSLVLAIGYAGTIGGLGTLIGTPPLIILKGQYMQHFGHEISFAKWMIVGIPTVIVLLGITWLYLRYVAFRHDLKYLPGGQTLIKQKLDELGKMKYEEKVVQTIFVLASLLWITREFLLKKWEVTSSVADGTIAIFISILLFIIPAKNTEKHRRIIDWEVAKELPWGVLILFGGGLALAKGISESGLAKWLGEQLKSLNGVSPILIVIVITIFVLFLTEVTSNTATATMILPILATLSVAVGVHPLLLMAPAAMAANCAYMLPVGTPPNAIIFGSGKISIKQMASVGFWVNLISAIIIILVVYYVMPIVLGIDINQPLPLK
The following text describes a protein:
Function:
Contributes to the wild-type cellular response to nitrogen stress through signaling pathways that regulate the expression of genes involved in amino acid biosynthesis. Required for wild-type filamentous growth, cell growth, and cell-cell adhesion.
Miscellaneous:
MISCELLANEOUS: Present with 1660 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Localizes to punctate patches in the plasma membrane that show extensive colocalization with SUR7.
Sequence:
MRNFFTLFFAAIFSLGALILAIVACAGSTKNYSPINKIYCAELDLSQMKVSTVLPSLSSATLSSLGLPSYINIGLWSYCTVDSSHNIQSCSSPHGIQNFNLSSLVYDNINNNEALELMDSVASVVLPEKLKSKMTYYNNLVKCMFITILIGIVLTFVNLVFNVLRWIIHIRPLTWFGAFFSFFAFAALLVSIGSCLGTYSYIKYILKHNYSDYGISMSIGRNYQGLMWGAVVGALLNFILWCSVRSRPTVIYANAPIEEKPLI
The following text describes a protein:
Function:
Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT) (By similarity). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity). Required for replication in human macrophages and in mouse lungs.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
In IrtB the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.
Sequence:
MIRTWIALVPNDHRARLIGFALLAFCSVVARAVGTVLLVPLMAALFGEAPQRAWLWLGWLSAATVAGWVLDAVTARIGIELGFAVLNHTQHDVADRLPVVRLDWFTAENTATARQAIAATGPELVGLVVNLVTPLTSAILLPAVIALALLPISWQLGVAALAGVPLLLGALWASAAFARRADTAADKANTALTERIIEFARTQQALRAARRVEPARSLVGNALASQHTATMRLLGMQIPGQLLFSIASQLALIVLAGTTAALTITGTLTVPEAIALIVVMVRYLEPFTAVSELAPALESTRATLGRIGSVLTAPVMVAGSGTWRDGAVVPRIEFDDVAFGYDGGSGPVLDGVSFCLQPGTTTAIVGPSGCGKSTILALIAGLHQPTRGRVLIDGTDVATLDARAQQAVCSVVFQHPYLFHGTIRDNVFAADPGASDDQFAQAVRLARVDELIARLPDGANTIVGEAGSALSGGERQRVSIARALLKAAPVLLVDEATSALDAENEAAVVDALAADPRSRTRVIVAHRLASIRHADRVLFVDDGRVVEDGSISELLTAGGRFSQFWRQQHEAAEWQILAE
The following text describes a protein:
Function:
Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Is a key regulator of stereociliary bundle orientation. Required for epithelial cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (sftpc). Involved in the negative regulation of canonical Wnt signaling, and activation of the non-canonical cascade stimulated by WNT5A. In non-canonical Wnt signaling, it may act as ROR2 coreceptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
Sequence:
MVTRTRPVAAMAVRSRSSSRTGTAYLLLVLCEVSWAQIFSFPFRRPETCDFNQYFDISALSCAPCGANQRRDALGTSCVCLPGYHMISNNGGPSIICKKCPENMKGVTKDGWDCISCPSGLTAEGKCHCPTGHILVERNVSGSLLAQATCELCDESENSFTKANALGTRCVRCEPTFVNTSRSCSCSEPHTLTGGLCFSNTGNFHQRVISTARYGELGMSLNSEWFAKYLQATAAACWTHANLTSCQALGNMCVMNMNSYDSTTLDACRLFHYIFESTAGLISVHSVPFWRQNLPWLFYGDQPGLAPQVLSTTPLPTNFSFKGQNQLKFVAASYDIRGNFIKWQPLEGGVLQLCPDTERRLDAAYAFGTTYQQNCEISLSKLLVDFSSPVFYDVYLEYTDEEQHRYLWPIPVLNLNLQHNKLFVNQDSSSSKWLLTRRIFLVDAVSGRENDLGNQPRVIRVATQISLSIRLVPNTKNGNIYTPLLTIAYSDIDIKNAHSQSAKISFSVKYEMNQGDASVHTDIALGVLGGLAVLSSLLKTAGWKRRVGSPMIDLQTVMKFLLYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPMPVQEERFVTYVGCAFAMKALQFLHKFISQISIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINPLFQVLTTLFFLEVVGFKNLALMDSSSSLSRNPSDYTAPYSRILRYAVATAIWLVIGIIQVVFFAAFYERFIEDKIRQFVDLCSMSNVSVFLLSHRCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFQIAVSSQMRQHYDRIHETLTRRNGPARLLSSSGSTFEQSIKAYHAMNKFLGSFIDHVHKEMDYFIKDKLLLERILGMEFMEPMEKSIFYNDEGHSFSSVLYYGNEATLLIFDLLFFCVVDLACQDFVLASFLTYLQQEIFRFIRNTVGQKNLATKTLVDERFLI
The following text describes a protein:
Function:
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKESRDRGFLLQIATVNSKTAKEGQRASAMAARKRGASKQPPPPTESHPKTSESAATSTDPQITPSKPSKIIFFSSIFFLPYLYLIFYHYRIETELKKSILINASLSFAGFFITLMMIPVASRYVLKRNLFGYDINKKGTPQGLVKVPESLGIAVGIVFLVVAILFQYFNFTSDSNWLVEYNAALASICFMILLGFVDDVLDIPWRVKLLLPSIAALPLLMAYAGHTTIMIPKPLVQYIGTEILDLGWIYKLYMGLLAVFCTNSINIHAGINGLEVGQTVVIAFAILIHNIMQIGASSNPETKQAHAFSIYLVQPLLATSLALLSYNWYPSSVFVGDTYTYFAGMTMAVVGILGHYSETLLIFFLPQIINFLLSLPQLAGIIPCPRHRLPRFDPGTGLLTGTKDGTLVNVSLRIFGRRSEKSLCILLLILQGVGCCFCFFLRWILTGWYK
The following text describes a protein:
Function:
CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC). The CzcB protein is thought to funnel zinc cations to the CzcA transport protein.
Sequence:
MSMIRTITYGILALLAMTLLVACSKGNGSREAGGEAGHGPVQMTAWSDRTEVFLEHPELEPGKGATLLIYLTRTADWKPLASSEVHLVITPPAGTPLTVAAKGTKPGLYRAEATFPAKGAYRLTVVIGGSQGEQIELPSLLVGEGHDHGEGEHKETAASDRKEGTPHDRDDHGDHAAETKQGGGKEPAHAEHDDHDEHAGHGGHDSHDDHEGEQAHDETGKAHAHAASGAVGAITLTKEQQWAVAFGVAEPRRMDMASGLTAVGELVPVATAEAVVAAPLAGVVSPTRALPFPGKRVAKGEVIAVIDPPASLGGGMTQLAADHAQAMSRLTLAQAEYDRAKRLVEGKIAARKRLEEAEASLEAARAVATPLETAMKSVQGGSGGRITVRAPVSGTVVEVPAVNGSGVAPGQTLVRIVDTGRLWLRVNLPATDLGKVGRPAAAGTTFTVTGLPGEFHTSGLVSDGTVVDPQTRTLPLVFAVENRSGNLKAGMFARVTIRTGTAKGVLAVPKEALFEDEGRWFAFVQISGITFDRREVQIGTEDQGMIQIVSGLDEHDRLVVKGGYYVKLASQGGATADPHAGHGH
The following text describes a protein:
Function:
Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Also plays a mitotic role in DNA replication.
Miscellaneous:
MISCELLANEOUS: Present with 1920 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus. Chromosome, centromere. Note=Transiently released from the nucleolus and localizes to the centromere regions during late pachytene.
Sequence:
MDPLTVYKNSVKQQIDSADLLVANLVNENFVLSEKLDTKATEIKQLQKQIDSLNAQVKELKTQTSQQAENSEVIKDLYEYLCNVRVHKSYEDDSGLWFDISQGTHSGGSSDDYSIMDYKLGFVKGQAQVTEVIYAPVLKQRSTEELYSLQSKLPEYLFETLSFPLSSLNQFYNKIAKSLNKKREKKDETE
The following text describes a protein:
Function:
Part of the HipHop-HOAP complex that recruits the MTV complex to form the terminin telomere-capping complex, which binds to chromosome ends in a sequence-independent manner and prevents telomere fusion. Telomere capping is independent of the origin recognition complex (ORC).
Miscellaneous:
MISCELLANEOUS: Multiple telomeric associations (TAs) in the same metaphase spread often result in multicentric linear chromosomes that resemble little 'trains' of chromosomes, hence the name 'caravaggio', the name of an Italian train named after the artist.
Subcellular Localization:
Nucleus. Chromosome. Chromosome, telomere. Note=Enriched at interphase, polytene and mitotic chromosome telomeres. Localized predominantly at telomeres and diffusely throughout regions of pericentric heterochromatin. Colocalizes with moi/modigliani at telomeres. Telomere localization is not dependent on peo/pendolino, tea, ver/verrocchio or moi/modigliani. Telomere localization is enhanced by, but not dependent on, Su(var)205/HP1. Telomere localization is enhanced by the activity of tefu/ATM and the MRN complex.
Sequence:
MLLLLCVNMSGTQMSAFLRKYLADEDKKIRAQFKESDPNNKLILWMHEKTRITEEDLARPYTEDEVKELCLRTKVKVDMTAWNCLWEAKKRFEAKGRFVNKSERFINRMYMKAVRRKMVQPYPEEFVAQRREIVAAETKKQNISRLDRWQKKKSQNLSAPESSPDAHASSNDAVQSHEDQANTNLSSLSQMNFQVEAMAPPGVSSSDLSGIGDDEDEQQQSGFQDENINRPETEINENSVRCDPINLGRMRTGCINSQANNSFRNTESDPDYYMFGTQLSTLVRPTSTQEPDDQVNCPETEMNESWVRCDQINSESLSIGPSIDSEGTITFQNTESEPIDVTSIA