lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
Subcellular Localization:
Nucleus.
Sequence:
MVRATILYLFTSDQAVKQIIKELDSQLHFIIEDLDDTHLFIEAAKVELVQDRLEDILEVFSSEAQN
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Sequence:
MRPRPEGRGLRAGVALSPALLLLLLLPPPPTLLGRLWAAGTPSPSAPGARQDGALGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGSPPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYAGHRGDDEAQAS
The following text describes a protein:
Function:
This protein binds beta-galactoside. Its physiological function is not yet known.
Sequence:
MSEKFEVKDLNMKPGMSLKIKGKIHNDVDRFLINLGQGKETLNLHFNPRFDESTIVCNTSEGGRWGQEQRENHMCFSPGSEVKITITFQDKDFKVTLPDGHQLTFPNRLGHNQLHYLSMGGLQISSFKLE
The following text describes a protein:
Function:
Probable transporter of a GTP-driven Fe(2+) uptake system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MENIRIALVGNPNCGKTTMFNYLTGSSQYVGNWPGVTVEKKEGKLKQHKDVKVIDLPGIYSLSPYTLEEVITRNYLITEKPEVIINIVDGTNLERNLYLSTQVMELGIPVIIALNMMDIVRKNGDIIDKDKLSKSMGCTVVETSALKGDGCKELIDKAIELAKSHKNNVIEHTFSNDVEKVLSDIENEIYNQVQKEHLRWFAIKLFENDEKAIEQGNISKASKDKVKAIVSSCEDELDDDGESIITNERYNYISKIISKCVVKKNKSKLTTSDKIDKIVTNRVLGLPIFAAVMFLVYYLSISTIGTGATDWVNDVLFGDIIPPAVEGFLTSIGTAAWLNSLILDGIIAGVGAVLGFLPQMMVLFLCLSILEDCGYMSRIAFIMDRIFRKFGLSGKSFIPMLIGTGCGVPGIMASRTIENESDRKMTIITTTFMPCSAKLPIIALIAGALFPGSVWIAPSAYFIGIAAIICSGIILKKTKAFAGEPAPFVMELPKYHVPGVKGVLIHMWDRAKSFVKKAGTIIFLACGLIWFLSTFNWSLAMVETPDSMLASMGKVIAPIFKPLGWGDWKSAVATITGLIAKENVVGTFGILYGAGEVAEDGVEIWKTLQGSFTQLSAYSFLVFNLLCAPCFAAIGAIKREMGNAKWTWLAVGYQTGLAYAVALVVYQLGSLFTGKGFGIGTLVALVLLVGFLYMLFRPYKDLTSSTNHKSNKVENISV
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MAKVSQPELKRFLDKRIAVNIQGGRKIQGTLRGFDMFLNLVVDEAIEQVHPEAGNPNVWQDGDRCGTVVVRGNSVTSLEALENVKTR
The following text describes a protein:
Function:
Part of an ABC transporter complex likely involved in xylitol import. Binds xylitol.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MNITSKIGAIAAAGAVGLGLTACGAGDTAANSDTKRIGVTVYDMSSFITEGKEGMDTYAKANNIELVWNSANNDVSTQASQVDSLINQGVDAIIVVPVQADSLGPQVASAKSKGIPLLAVNAALETPDLAGNVQPDDVAAGAQEMQMMADRLGGKGNIVILQGPLGGSGEINRGKGIDQVLAKYPDIKVLAKDTANWKRDEAVNKMKNWISSFGPQIDGVVAQNDDMGLGALQALKEAGRTGVPIVGIDGIEDGLNAVKSGDFIGTSLQNGTVELSAGLAVADALVKGEDVKTDPVYVMPAITKDNVDVAIEHVVTERQKFLDGLVELTQQNLKTGDIAYEGIPGQTQP
The following text describes a protein:
Function:
Flavin-dependent halogenase; part of the gene cluster that mediates the biosynthesis of DIF-1 (Differentiation Inducing Factor-1), a signal molecule involved in the differentiation of pstO (prestalk-O) cells. The three-step process begins with the formation of (2,4,6-trihydroxyphenyl)-1-hexan-1-one (THPH) by the polyketide synthase StlB. THPH is then dichlorinated by the flavin-dependent halogenase ChlA. The last step of DIF-1 biosynthesis is the O-methylation of dichloro-THPH (or des-methyl-DIF-1) by the methyltransferase DmtA to yield DIF-1.
Sequence:
MDTNIINHYDIIIIGGGIAGLSATRHLLLKMPELSGRIAVIEPRSERRDNLDEDYKVGESTVEVSAMFFAKELELQDYLIENHPPKFSLQFHWPRELSKTDTIEDYYSTWAVKNPDIQAFQLNRCKIERDLLKMVIAQGAVYYHGRVRNVDNLDNDDMKSIDVEILSEVESGADFKLQQSIERITLTTDYIVDASGRNFTVGSRTDNILKDPKHLFGLDNASTWVRVKNTERSLFDFKSQDVTCSWTYDTNHFFGPGYWIWMIPLERGSRDYSIGVSYHRDKIQPSQLNSLDKFMSFLEKNQKLLYNLIKSGEIVDFHRWPKLAHTSKTFFSKNNWCVIGDAAAIFDPFYSTGMVMIAMEIECLTEMLKFKLSNAANDYHRRVEAFDKLIRCVTQINNHLIKDHSNHLGNASIMSWRIYFESSTYFSILLPAYIGKYHLCPIFSDHFTTDHENGLALRNQLLATLDYANENSINIGFMDNHRGGQLLGDWSPTSSWDYDHALSLAKYGHKRLNLPKCLSWSNFYLSLIICKLYYRVYGIGALWNSSFFKSLSNTTYRFSKFYFLSKLHSFNMIGTPNNDYYDKIQKDFKSYNYNQNNIVDWKY
The following text describes a protein:
Function:
Catalyzes the FAD-dependent oxidative deamination of various amines and D-amino acids to yield the corresponding alpha-keto acids, ammonia/amine, and hydrogen peroxide. Oxidizes sarcosine (N-methylglycine), N-ethylglycine and glycine. Can also oxidize the herbicide glyphosate (N-phosphonomethylglycine). Displays lower activities on D-alanine, D-valine, D-proline and D-methionine. Does not act on L-amino acids and other D-amino acids. Is essential for thiamine biosynthesis since the oxidation of glycine catalyzed by ThiO generates the glycine imine intermediate (dehydroglycine) required for the biosynthesis of the thiazole ring of thiamine pyrophosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTSAAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSEEDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKAAKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNAFLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLESVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILLAPATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI
The following text describes a protein:
Function:
ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Binds and transports smaller and larger peptides with the same affinity. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein.
Sequence:
MRVAVIVSCNLVFTLVDIVLTTVLYIHGSNIDIFSDETEDFDIHRSTVDLWGTVLIRVSLLFGASIGVFFNRRDGPRRVSNLGTLVALICLTNMTYALAKLLMLSEEGNLMYDPWFLSLFSWTCVAAIGVMIFWKILSQTPNAVSDREDSEDTERLVDETEDESEKSMKSGKEHTHSGATIGRLLSYCKKDSSLLSIAFFFLLLSAVCEAFIPYYTGQAIDGIVIQKSMDHFAKPMITLSVLALVSSIAIGFRGGVFSVTFARLNIRLRNLLFRSLMHQEIGFFDANHTGDITSRLTSDTTQVSDLISQNVNLFLRSFVKAVGIFIFMFGMSWKLSVVTIMGFPYIAVVSKLYGEYYKKLTKEVQTALAQANKVAEETISAMRTVRSFANEDQEGDMYYSRLQEMFVLNKKQAIAYACFMWSSYISELALQVAILFYGGHLVVTNQMSGGTLISFVIYELELGEALESISSVYTGLMQGVGAAEKVFEYIDRKPKHALNGQEAPETLEGQVEFNNVTFAYPSRPEMDVLKNVSFSLRPGQVTALVGPSGGGKSSCVCLLENFYAPQQGQVLVDGRPVNTYQHKYYHSKVALVAQEPVLFARTVQMNISYGVPEAPMEAVIRAAINANAHDFITGLSKGYDSGVGEKGTQLSGGQKQRVAIARALIRSPRILILDEATSALDSESEYIVQQALNNLMREHTVLVIAHRLSTVERADNILVIDKGSVVEQGPHAELMARGGLYCKLVQRQILGTEIDVDDKNPSPAPTWELKTEDKENAEDCSDTEYETRY
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MDPHHSLRTIYPYIIILILSLNSMGCKAQLSPTFYDSTCPNALTVIRTSVRTAVSRQRRMAALLIRLHFHDCFVQGCDASILLNDTPTTERTTFSNVGVGGYEVIDAAKSAVENICPGIVSCADILAVAARDASVSVGGPSWSVGLGRRDSTAAYPSQADSDLPRADQDLQSLISDFQVKGLSERDMVALSG
The following text describes a protein:
Function:
Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Nucleus.
Sequence:
MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPASGEEPGPGGGDRAPAGESLLGPGPLPPPPSAHHPGLGAEAGGGISGGAEPGNGLKPRKRPRENKEVPRASLLSFQDEEEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNTAADSDQPLDKTCHAKDTNPEDGVVISEHGEDEMDMESEKEEEKPKAGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQLARELGDFTPHDSEPGKGRLVREDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEIGIEGSDDDALVTGEQDEELSRWEQEQIRKGINIPQVQASQPSEVNVYYQNTYQTMPYGASYGIPYSYTAYGSSDAKSQKTDNTVPFKTPSNEMAPVTIDLVKRQLKDRLDSMKELHKTNQQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHSNKALMAPNLDSFGRDRALYQEHAKRRIAEREARRTRRRQAREQTGQMADHLEGLSSDDEETSTDITNFNLEKDRILKESSKVFEDVLESFYSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLEAKCRDFETMLWFESLLFYGCEDREQEKDEADVALLPTIVEKVILPKLTVIAETMWDPFSTTQTSRMVGITMKLINGYPSVVNADNKNTQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFFQRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIRKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLLASVRALDHAISVASDHNVKEVKSLIEGK
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MNLNATILGQAIAFVLFVLFCMKYVWPPLMAAIEKRQKEIADGLASAERAHKDLDLAKASATDQLKKAKAEAQVIIEQANKRRSQILDEAKAEAEQERTKIVAQAQAEIEAERKRAREELRKQVAILAVAGAEKIIERSVDEAANSDIVDKLVAEL
The following text describes a protein:
Function:
Endoribonuclease; (Microbial infection) Required for the initial stages of clathrin-mediated endocytic uptake of a diverse set of flaviviruses, including dengue and West Nile. Not required for clathrin-mediated endocytosis and macropinocytosis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKICGPKLSLCGLIISVWGIVQLVLMGLFFYINSVALIEDLPLEEEYHSLEDFYAAANRAYNQNAYNCWIAACIYVLTLLLSAQQFYMNSRVTAN
The following text describes a protein:
Function:
Has an antimicrobial activity.
Subcellular Localization:
Secreted.
Sequence:
MHCLKIMAFLLFFSLLLSQVYCASLHQPQPLLRLKRMTPFWRGVSLRPVGASCRDNSECITMLCRKNRCFLRTASE
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II.
Subcellular Localization:
Cytoplasm.
Sequence:
MSWLVFLAHRVALAAVSCRCGSRGFGMFYAVRRGRKTGVFLTWNECKAQVDRFPAARFKKFATEDEAWTFVRKSASPEVSEGQENQHGQELQMKASKRLREPLDGDGDESAEPYAKHMKPSMEPAPPVSRDTFSYMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQTNQRAEIHAACKAIEQAKAQNISKLVLYTDSMFTINGITNWVQSWKENGWKTSAGKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLARKGAKQLED
The following text describes a protein:
Function:
Regulates the lysine- and pH-dependent expression of the lysine decarboxylase CadA and the cadaverine-lysine antiporter CadB. At low external pH, and in the presence of external lysine, CadC activates transcription of the cadBA operon by binding directly to two sites, Cad1 and Cad2, within the cadBA promoter region (Pcad). Preferentially binds to AT-rich regions within the Cad1 promoter.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Note=Membrane insertion requires the SecA translocase.
Domain:
Contains a cytoplasmic DNA-binding N-terminal domain, a transmembrane domain and a periplasmic C-terminal domain. A cluster of aromatic amino acids within the transmembrane domain is important for lysine-dependent regulation of CadC. The transmembrane domain of CadC is important for the interaction with LysP, but the periplasmic domain of CadC is also important in facilitating correct positioning of the two proteins. A cluster of negatively charged amino acids (Asp-198, Asp-200, Glu-461, Glu-468 and Asp-471) forms a negatively charged patch on the surface of the periplasmic domain and is crucial for pH detection. Dimerization requires the periplasmic domain, but not the transmembrane domain. Conformational changes at the dimer interface may functionally influence the transcriptional activity.
Sequence:
MQQPVVRVGEWLVTPSINQISRNGRQLTLEPRLIDLLVFFAQHSGEVLSRDELIDNVWKRSIVTNHVVTQSISELRKSLKDNDEDSPVYIATVPKRGYKLMVPVIWYSEEEGEEIMLSSPPPIPEAVPATDSPSHSLNIQNTATPPEQSPVKSKRFTTFWVWFFFLLSLGICVALVAFSSLDTRLPMSKSRILLNPRDIDINMVNKSCNSWSSPYQLSYAIGVGDLVATSLNTFSTFMVHDKINYNIDEPSSSGKTLSIAFVNQRQYRAQQCFMSIKLVDNADGSTMLDKRYVITNGNQLAIQNDLLESLSKALNQPWPQRMQETLQKILPHRGALLTNFYQAHDYLLHGDDKSLNRASELLGEIVQSSPEFTYARAEKALVDIVRHSQHPLDEKQLAALNTEIDNIVTLPELNNLSIIYQIKAVSALVKGKTDESYQAINTGIDLEMSWLNYVLLGKVYEMKGMNREAADAYLTAFNLRPGANTLYWIENGIFQTSVPYVVPYLDKFLASE
The following text describes a protein:
Function:
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Subcellular Localization:
Cytoplasm.
Sequence:
MHFTIQREALLKPLQLVAGVVERRQTLPVLSNVLLVVEGQQLSLTGTDLEVELVGRVVLEDAAEPGEITVPARKLMDICKSLPNDVLIDIRVEEQKLLVKAGRSRFTLSTLPANDFPTVEEGPGSLNFSIAQSKLRRLIDRTSFAMAQQDVRYYLNGMLLEVNGGTLRSVATDGHRLAMCSLDAQIPSQDRHQVIVPRKGILELARLLTEQDGEVGIVLGQHHIRATTGEFTFTSKLVDGKFPDYERVLPRGGDKLVVGDRQQLREAFSRTAILSNEKYRGIRLQLSNGLLKIQANNPEQEEAEEEVQVEYNGGNLEIGFNVSYLLDVLGVIGTEQVRFILSDSNSSALVHEADNDDSAYVVMPMRL
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDVIPSTTPGEAVRISAKRTAELFGPEYLMVTPSASNGSIGVSYRRKTEYEHVKELPPALAAKQAQAAAARSKRPKISSRSEGSGSGDKSGASTALVRRGGRASGAAGDDKPTSLIQRPSATRQQPPEWHAPWKLMRVISGHLGWVRSLAVEPNNEWFASGAGDRTIKIWNLATGALRLTLTGHISTVRGLAVSPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYTLALHPRLDLLVTGGRDGVARVWDMRTRSNIHVLSGHTGTVADVQCQEADPQVITGSLDATVRLWDLAAGKTMGVLTHHKKGIRSLATHPREFTFASASTGSIKQWKCPGGEFMQNFEGHNAIINTLSVNEDNVLFSGGDNGSMSFWDWKTGYRYQTIDTTAQPGSLEAEAGIMTSTFDRTGLRLITGEADKTIKVWKQDDQATPETHPVTWAPTLGRQRY
The following text describes a protein:
Function:
Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) to free glucose and ceramides (such as N-acylsphing-4-enine) (By similarity). GlcCers are membrane glycosphingolipids that have a wide intracellular distribution (By similarity). They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties (By similarity). Involved in the transglucosylation of cholesterol, transfers glucose from GlcCer to cholesterol, thereby modifying its water solubility and biological properties (By similarity). Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl-3-beta-D-glucoside to ceramide (such as N-acylsphing-4-enine). May play a role in the metabolism of bile acids. Able to hydrolyze bile acid 3-O-glucosides as well as to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity. Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the galactosyl transfer between GalCers and cholesterol in vitro with lower activity compared with their activity against GlcCers (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localization to the plasma membrane and alternative topologies have also been reported.
Sequence:
MVTCVPASEQIGCAERDSQIYSEDTGGTEAVRVTDCRSPEDSGPQNEPGYCNSEDSGQLMASYEGKARGYQVPPFGWRICLAHEFAEKRKPFQANNVSLSNLVKHFGMGLRYLKWWYRKTQVEKKTPFIDMFNSVPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHQTVIADQFIVCLRRDGRTVYQQVLSLELPSVLRSWNWGLCGYFAFYHALYPRAWTVYQLPGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDETLDVSIMFSMRNGLGGEDDAAGGLWNEPFRLEQDGTTVQGLLLHHPTPPNPYTMAVAARHTADTTVTYTTAFDPDSTGQQVWQDLLQDGQLDSPAGQSTPTQRGEGVAGAVCASSKLLPRGRCCLEFSLAWDMPRIMFGAKGQVHYRRYTRFFGSDGDVAPALSHYALCQYAGWENSISAWQNPVLDDRSLPAWYKSALFNELYFLADGGTVWLEVPEDSLPEELGGSMYQLRPILQDYGRFGYLEGQEYRMYNTYDVHFYASFALVMLWPKLELSLQYDMALATFKEDLTRRRYLMSGVVAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYYLTGDQGFLKDMWPVCLAVMESEMKFDKDQDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAVAVMVQMAVLCGAQDVQDKFSSILCRGREAYERLLWNGRYYNYDSSSQPQSRSVMSDQCAGQWFLRACGLGEGDTEVFPTLHVVRALKTIFELNVQAFAGGAMGAVNGMQPHGVPDRSSVQSDEVWVGVVYGLAATMIQEGLTWEGFRTAEGCYRTVWERLGLAFQTPEAYCQQRVFRSLAYMRPLSIWAMQLALQQQQHKKNSSRPAVTQGTAPSQPECGPKRSL
The following text describes a protein:
Function:
Nucleotidyltransferase involved in the post-translational modification of proteins. It can catalyze the addition of adenosine monophosphate (AMP) or uridine monophosphate (UMP) to a protein, resulting in modifications known as AMPylation and UMPylation.
Sequence:
MTHLQFDNRLRAELPGDPEEGPRRREVLAAWSAVQPTPVAAPTLLAYSADVAQRLGLRAEDLASPRFAEVFGGNALYPGMQPWAVNYGGHQFGHWAGQLGDGRAISLGEAIGVDGGRYELQLKGAGPTPYSRGADGRAVLRSSIREFLCSEAMHYLGVPTTRALSLVGTGDAVVRDMFYDGHPRREPGAIVCRVAPSFIRFGNFELPAARGDVDLLRQWVDFTLARDFPDLPGSGEDRIASWLGQVCERTAVMVAHWMRVGFVHGVMNTDNMSILGLTIDYGPYGWVDDYDPDWTPNTTDAQGRRYRFGTQPQVAYWNLGRLAQALSPLFGDAAPLQAGLDQFRDTYLACDRRDTAAKLGLAECQDEDLHLIDDLRALMREAEMDMTLTFRGLVDLSPQQPDASVLREAFYDETKRAAQAPALGAWLQRYAARCLQDGASDAVRASRMRAANPRYVLRNYLAQQAIDQAEQGDLSGVHALLEVMQRPYDDQPRRESFAAKRPDWARDRAGCSMLSCSS
The following text describes a protein:
Function:
Involved in oxygen transport from the lung to the various peripheral tissues; Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand. Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide. Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity.
Subcellular Localization:
Cytoplasm, sarcoplasm.
Sequence:
SSTMSFSEAEVQSARGAWEKIYVDAEDNGTAVLVRMFTEHPDTKSYFTHFKGMDSAEEMKQSDQVRGHGKKVFTAINDMVQHLDNSEAFLGIVNPLGKKHATQLKIDPKNFRIICDIILQLMEEKFGGDCKASFEKVTNEICAHLNNVYKEAGW
The following text describes a protein:
Function:
Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis. Involved in the negative control of vitamin D receptor signaling pathway. Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway. May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney. Through the Rho signaling pathway may also regulate cell proliferation (By similarity).
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MAQVLHVPAPFPGTPGPASPPAFPAKDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPRLSSLPRGPGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGALETRGGFNPRVERTLLDARRRLEDQAATPTGLGSLTPSAAGSTASLVGVGLPPPTPRSSGLSTPVPPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPTAGRGRSELCLDLPDPPEDPVALETRSVGTWVRERDLGMPDGEAALAAKVAVLETQLKKALQELQAAQARQADPQPQAWPPPDSPVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLEPYGTGLRALAMPGRPESPPVFRSQEVVETMCPVPAAATSNVHMVKKISITERSCDGAAGLPEVPAESSSSPPGSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVRSIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENEAPEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLALEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSDDESPTSSSAEE
The following text describes a protein:
Function:
Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Cytoplasm. Note=As stem cells differentiate, translocates from the nucleolus to the nucleus and then to the cytoplasm. Colocalizes with NPM1 and NCL in the nucleolus.
Sequence:
MEKLQAQYCYLCSENIRKTNPFILNILQKLDEEIEKRPKEKFTVNIAGNNRLDSGQRITGEDFWLLSKTLRNQPCISGVDVRYNLIGDVGAFYAAKLLQKQPSITYLNLMFNDIGPEGGELIAKALHKNKTLKYLRMTGNKIENTGGMLFAAMLQMNSSLEKLDLGDCDLGLQCVIAFSTVLTQNQAIKGINLNRPILYGEQEESTVHIGHMLKENHVLVELHMCKHGMKNYGLQQLCNALYLNSSLRYLDVSCNKITRDGMVFLADVLKSNTTLEVLDLSFNRIETAGAKYLSETLTSHNRSLKALSVVSNKIEGEGLVALSQSMKTNLVLSNIYIWGNKFDEDTCVAYSDLIKSGRLKPDNTDVEPYMVDEHIYLSEVSNGLKRHYYWAPTYGETYMPSSSAGFALVPVGEHL
The following text describes a protein:
Function:
Connects telomeres to the nuclear envelop (NE) during both vegetative growth and meiosis. This connection ensures clustering of telomeres to the spindle pole body (SPB) when cells enter meiotic prophase.
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus inner membrane; Peripheral membrane protein.
Sequence:
MTENEKSRSLPAERNPLYKDDTLDHTPLIPKCRAQVIEFPDGPATFVRLKCTNPESKVPHFLMRMAKDSSISATSMFRSAFPKATQEEEDLEMRWIRDNLNPIEDKRVAGLWVPPADALALAKDYSMTPFINALLEASSTPSTYATPSRPTAQKSETSEGEPESSTSATTTSVARRTRQRLAEHLENSKKTILQHDNKEEDKEIHSEENETKDEIKSEKKEPEIKKQEGGSSTEKVGQPSSSDDKAKGSTSKDQPSEEEEKTSDIQDRKIKTPIKPSLLGKIRSSVNKGMTDVASQVNRGMTDVASQVNKGVNGVASQVNKGMNGVANQVNKGVTGVASQVRKPVGKLEKKFENLEKSIGDTLKSSIRSSPKSKKRSREDFEENEDYNAMVPVKRSRITKLESEVYYEKRKVRALGGIAIGLGVGAILPFLF