lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
Subcellular Localization:
Cytoplasm. Mitochondrion intermembrane space.
Domain:
The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation; The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters; The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
Sequence:
MANNVGVLLATDMQALPDSVEQWAIKNYEDKLSGGASLQVAKNILESSFKLEAGTSSMGAVVSLVQTPGLHSPAYLAEVARVLVSGGDLIVQEPLLAEAQEQKCSSAQTKAQLERNLLLAGFVNLEVVDSVVGVEIAKACTTSSVALNVVAVKSSKPSWDTGSVFQIRKKVSNQNGNFRTSGNYQPVKLTAGETVDDFPLNSKPAVKVDLSSDFKNDEEELIDEDDLLTEEDLKAPVLPAAESCAPTKKACKNCTCGRAELEEKEQETKLTTAQINNPTSSCGSCGLGDAFRCAGCPYRGMPTFKLGEKITLGGSLLVADA
The following text describes a protein:
Function:
Able to suppress the functional loss of YPT1. May form a channel. Protein SLY41 is not essential for cell viability. The SLY41 gene is a multicopy suppressor.
Miscellaneous:
MISCELLANEOUS: Present with 784 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIQTQSTAIKRRNSVHKNLFDPSLYQIPEPPRGGFQHQKKEYSKETFSNQVFGYDITSLKKRFTQLFPSNIQGYLPEVDLRITIICSIWYVTSSISSNLSKAILRTFNHPIALTELQFLVSAVLCVGFASIVNLFRLPRLKHTKFSKALNSFPDGILPEYLDGNFRSSILHKFLVPSKLVLMTTFPMGIFQFIGHITSHKAVSMIPVSLVHSVKALSPIITVGYYKFFEHRYYNSMTYYTLLLLIFGVMTTCWSTHGSKRASDNKSGSSLIGLLFAFISMIIFVAQNIFAKNILTIRRKVGILPSSSTDDVTSKEGQPSLDKTRFSPLQVDKITILFYCSCIGFSLTLLPFLTGELMHGGSVINDLTLETVALVAIHGIAHFFQAMLAFQLIGLLSSINYSVANIMKRIVVISVALFWETKLNFFQVFGVILTIAGLYGYDKWGLSKKDGRQA
The following text describes a protein:
Function:
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
Subcellular Localization:
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Sequence:
MEDLQLVLFVLGAIAIVAVLVHGFWSIRRQQPKSLKDSPMGNFYKKQAERGEAAPAPKRVDAEGFDSDGIGAVRVRKASESQTPEAPAVNPYLKQEAKVEPQIEPKPQFKQEPSMAQPDFSLQSPSVDEPHRGTKASRQEPVLKSNTAHLNQEHAGQSHAAMVAQKVAEEQRAQVQKPTQTALFDDEVYQEQQPQAVEEAPETEESLGEPRDVLVLHVVAKEGQQLNGAELLPCFLTLNFKYGDMNIFHRHVDNAGNGKVLFSIANMVKPGVFDPDNMEQFSTLGVVFFMTLPCYGDALMNFSIMLNSARQLADDIDAVVLDGQRQPWGEFTKQDYLHRIRANA
The following text describes a protein:
Function:
Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Sequence:
MSLSRISRMVTSSTKKFSPHKMIDNIYLRTSRVAELCVSKYRDTECACLLKQSELGGLKFASFRNLNLFYGGSMLKYDLGSRQQFNYFQIEQFSTHGVEKSSVSRNMGRSGFQSSQVLQGGKSQAMLLYLVALVVAMVGCTYAAVPLYRRFCQATGYGGTVQLRETVEEKIARHAQDGTTTSRELVVQFNADVADGMPWKFIPTQKEVKVKPGESALAFYTAENNSSTPITGVSTYNVTPMKAAIYFNKIQCFCFEEQRLLPGEQIDMPVFFYIDPEFETDPKMASVNNLILSYTFFKIGEE
The following text describes a protein:
Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MNDSLTKLLDLARGALPELTDCYFFLIGRHGSGKSSLIANFSPEVKELQSRSTFGYEYTDFVHDNKYLIHIYEFNDTAYNNLLFDLIKENIDKSCIIFTFDINHPTTISTDVTNIIAPLYTSLNQFFENTTRQKDLEKYYSTICSKDPINHSQSTMKINTYVPTVFVGTFDESLEDLSDPKFDGYMNYLREAAIPYGASITLSKSKIALELFIYLSLREQISEFYWDKVCERTNYFIPPAWDSIEKVEAVEKEVIEEAEKEIHESDEIKVQDYNSFLSELAKNGHIFSTTSRKKFMSPEKLSSAGQDDYLKQFM
The following text describes a protein:
Function:
Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.
Subcellular Localization:
Cytoplasm.
Sequence:
MLNETPALAPDGQPYRLLTLRNNAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPECYQDQAAFLGASIGRYANRIANSRYTFDGETVTLSPSQGVNQLHGGPEGFDKRRWQIVNQNDRQVLFALSSDDGDQGFPGNLGATVQYRLTDDNRISITYRATVDKPCPVNMTNHVYFNLDGEQSDVRNHKLQILADEYLPVDEGGIPHDGLKSVAGTSFDFRSAKIIASEFLADDDQRKVKGYDHAFLLQAKGDGKKVAAHVWSADEKLQLKVYTTAPALQFYSGNFLGGTPSRGTEPYADWQGLALESEFLPDSPNHPEWPQPDCFLRPGEEYSSLTEYQFIAE
The following text describes a protein:
Function:
Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract. Required for the establishment of radial spokes in sperm flagella.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MSAFINVPRARLLEPNAALSPLLQEILRHCERRNIRYDRPLVHFVMNLLSLDPRYELFMETVSAERRNHDDFVEACCTVLNDDRSPTLITLRMQCYFLGNFFDRDEIVEKHARNLQAKTFALTKEIIDHDVITKDEQDEVFNKVIVDIVVNMGLGNPECKDVMAETMRALNSVMSRSDKAKFVTLDRKERLMALKDIREIVAGIRIFNKHSGNTANGMADLPKIIDQSHESTKSILQITLCEIMDKVNLLTSALSAAIAYDLRNRSIITLLPENITADDFETIKDLLAMYRQHEVYTRKLIDELAGIKLLIDGCKQEYEARLLRIHEAVQYRTAIPTDRVFPKFSELTRVWLQFQNFVFLLSEMNQISNTLTSLTERCASFDDLAYRLLGESQIQTDIDRLNKVSAKRLSLPDPKSCEIVPYEEGMQMQLLKFCLWHLAEGKGLLMPGSIELGVCRVQKEHYLFNIPEPVTFFDEDPNKYFFKIVETARKKVQLICLLNMYDKLQASYSAPRCEGFQMKLTTTCDQEVQTDLHPIPSNIDREYRWNVWDYRREAIRLANIRTKRTTSVQTLESSRAIPKSTQVYLDKVQSTQTRVSRSTETEQRRQTTGLKVIEPSAPSPLKVYALTLAQASRSGFNRNGER
The following text describes a protein:
Function:
Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA).
Sequence:
MLWKRAATLEQLNQQSQGCMVGHLGIEFTRLSDDELEATMPVDSRTTQPFGLLHGGASVVLAESLGSMAGYLCTVEGQQVVGLEINANHLKSVRSGNVRGCCRAIHVGRSHQVWQIEIFDEQGHLCCTSRLTIAVLTR
The following text describes a protein:
Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MVNGGLQIGGFLLGLIGWILGIVTCALPDWRKNDLQGEVIESVIRTTGLWVRCTTQATGLWTCDDYDSFFLGLPVALQAARACVCLSIAMGFLSCICSVFGLECTNISAGNPKMKARITLVAGLLNFIGGVSVGIAVSWFAANVLQEYWNPLGAATSNTRYVYGSALFVGWISMAVSVIAGLVQCCSSWNVDDEDNGRPYTYNPSKPKASSAEYI
The following text describes a protein:
Function:
Plays a role in skin pigmentation by antagonizing the action of melanotropin alpha. Induces melanin concentration within the melanophores. May participate in the control of the hypothalamo-pituitary adrenal gland axis by inhibiting the release of ACTH.
Sequence:
MRRSVMSVIFATVLLFDCYAPSVASPMANTEDGSMEQDAFTSLLTNEATDNSLGEVEPIPVTKARVPRVIVIAADPSLWRDLRVLHGGLSVYKRTADDNNQVLEHRNLAQQLNIPILRRDTMRCMVGRVYRPCWEV
The following text describes a protein:
Function:
Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Sequence:
MFHYASYFCQDVGKGEGSDDVGSDALDFEGLTPVDVRTAHDTGGVEDMSGLEREVPFWRRPELYWKGMSWARQRYKTAYFSFYLPVACALLMAGEDLDKNVDVKNILVEMGTYFQVQDCFGDPQTIGKIGTDIEDFKCSWLIVKAFELSNEQQKKFLQENYGKPDPENVAKVKALYNELNLQGVFEEYESGSYVKLVSSIEAHPSKAVQVVLKSFLAKIYKRQK
The following text describes a protein:
Function:
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MQFVNSGISVTDLRKTFGNSEIIKGVTLDIEDGDYVSLTGKSGSGKSTLLYMISSLDPPSSGTIKIDKKDIYRMNEEEIHEFRNKRMGFIFQFHYLLPEFTAIENVLMPARKAGLLKEYQSYAEHLLEEFDLKDRMNYRINRLSGGQAQRVAIARALVMNPKYIFADEPTGALDSTNTKVVMNILEKVNRETKTTILVVTHDPDFASKTKRQIHLVDGRVVSLKEFEAIKKSVKTAR
The following text describes a protein:
Function:
Probably involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MWQLILFVLFVDIVSVHCHIYDEASSVSLINRIDRYHRSTGDDEFDDGVNLFDDHGHTGHDDEDLIGTSRYTNEWVVKITGGAKSAAKLAEEMGFDIHGTVQSFPDLYRLHKSDHPRRGRAQSSHVSRQLAADVRVMWAEQQFAKRRQKRGYIPDDRLFETAEESATNEEDRPLVRVKRESDENEPRIRQKRSDMEAPSKSSHRFNDELWDHQWYMHDTRTNAALPRLDLNILPVYDMGYTGRGVTVVVLDDGLEGTHTDIRNNYNSKVSFDMNDDDPDPSPRYGRGYFNSHGTRCAGEIAMEANNAKCGVGVAFNVSIGGVRMLDGPVSDRVEASSLIYALEMVDIYSASWGPSDDGKTVEGPGKLVRQAFYRGVKEGRKGKGAIYIWASGNGGRVKDNCNCDGYVSSIYTLSIGSVSEQGDFPWYGEQCASTMAVTYSSGAYTDQKIATVDLNDTCTMDHTGTSAAAPLASGIVALALEANSNLTWRDVQHLVPWTSEYGPLKDNIDWQENSAGFRVNPRFGFGLMNAAKYVRAAINWSTVPEKSICVTPSFNGLPVLFTNKEWGTVEFESDGCSGTLDEVNYLEHVEVIVSIEYPIRGQLEIDLISPSGTSTQLVKQRPKDKSKQGYVNWPFMSVHTWGEMSKGRWKLIMTDLNSSLLSGRIVNATLVLHGTSAMPEYRKNGTRIYDDAFSRLSSRSVRIYIFHYNRRSTTGSFRPYARSIPQNHRPM
The following text describes a protein:
Function:
Component of LSM protein complexes, which are involved in RNA processing. Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by promoting decapping and leading to accurate 5'-3' mRNA decay. The cytoplasmic LSM1-LSM7 complex regulates developmental gene expression by the decapping of specific development-related transcripts. Component of the nuclear LSM2-LSM8 complex which is involved splicing nuclear mRNAs. LSM2-LSM8 binds directly to the U6 small nuclear RNAs (snRNAs) and is essential for accurate splicing of selected development-related mRNAs through the stabilization of the spliceosomal U6 snRNA. Plays a critical role in the regulation of development-related gene expression.
Subcellular Localization:
Nucleus.
Sequence:
MGSEEESTVKEPLDLIRLSFDERIYVKLRSDRELRGKLHAYDQHLNMILGDVEEIVTTIEIDDETYEEIVRTTRRTIPFLFVRGDGVILVSPPLRTA
The following text describes a protein:
Function:
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Subcellular Localization:
Cytoplasm.
Sequence:
MNNRRFDCIGIVGHPRHPAALATHEILYHWLKARGYAVMVEQQIAHDLNLTDAITGSLADIGQKADLAVVVGGDGNMLGAARVLARYDIKVIGVNRGNLGFLTDLDPDNALQQLSDVLEGEYLSEQRFLLETHVRRTNQQSRISTAINEVVLHPGKVAHMIEFEVYIDDRFAFSQRSDGLIIATPTGSTAYSLSAGGPILTPTLDAIVLVPMFPHTLTARPLVISSSSTIRLKFSHITSDLEISCDSQIALPIQEGEEVLIRRSDFHLNLIHPKDYSYFNTLSTKLGWSKKLF
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQALTLTSIFAPQHVVSKILGVLPFTIQDGRPVFSKLGLCHSFLCIILYVFVAQSYYQTIFDDTTSGFITLKILKFITIARYVGYTAVMINTFVAVGLTYKKFVALLSKLYGIDRGLGKLGLETFVVASGYRIKKKMFLLVILEYLIGNIVSIFSSQFNDISGAFVLLYPRMIGCNLSVTYFGTTLLLEERFKLVNKFLLGECFKSRNCTKYPTDPNFCDKIKLSVNIHKELTRICRAINSIFSVFFLLWVTVNFLCLVSDLYIVAYLISSGQFFNYWQGELKAFKNVCIYSIEMFYIARRSSRLCSQANRTKTILVGLKVDLSKEEERNTIITSSLELRQFTLQITACRLFTIDNALLFSICGAAFSYLFIMIQMDKDLNKSLRNVTNSIL
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MSQLREEKSEKMRYSALHSCLWVMFLLLFHALNVDGNSKGAIQGAKWKPLCTLTADANKVYNRALKLQILITDYTKAATKLAVEAVAAAQKMQNAEAHAAAIGLVAEIREQLKSKQPEIARCYKVAVETPAFIGYTHGRIAEFLEIMGHNRGASNYGYLAQLSSPTSPATDAATAQLSSCKIKPHDITEGPEETEVLTKKGFVGMDHGTGLVDGVLTSSCNEHCVLTSATATALNSDTGPQEDIPFTNGYILKHQTNTARSSQLINSLSKQAKGLPNKGQNQQYVRLWDKYVQLEGCETSFKAGFSKPEAQTLKQSVAVLTALKNIIDNESGEYDLSKDGEQIKTVAEKLFKHGEDNYPEKLYKEAQAKTLRKTLMAGNTATSLTNLETPIDLQIAQMYYTQRKIDGFIAKLKEAEEQLSKDKLGDYGAAAAEHACNKLDGEQKCNTDKKCSYETASDGTNKCTYNASKAKANNVPVAPTQTESAKKTTKKCKGKKKDDCKSPDCKWEGETCKDFSFLVNTKSTLMAATFLSFFKIFHPLFPC
The following text describes a protein:
Function:
Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.
Subcellular Localization:
Cytoplasm, cytosol. Early endosome membrane; Peripheral membrane protein.
Sequence:
MADEDGEGIHPSAPHRNGGGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNGVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQAVPISVPTYKHVEQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELRVALPDGTTVTVRVKKNSTTDQVYQAIAAKVGMDSTTVNYFALFEVINHSFVRKLAPNEFPHKLYVQNYTSAVPGTCLTIRKWLFTTEEEILLNDNDLAVTYFFHQAVDDVKKGYIKAEEKSYQLQKLYEQRKMVMYLNMLRTCEGYNEIIFPHCACDSRRKGHVITAISITHFKLHACTEEGQLENQVIAFEWDEMQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKWRKEEAGEGWRVEQ
The following text describes a protein:
Function:
May be a redox sensor protein. Negative transcriptional regulator involved in the post-transcriptional modulation of the GATA-type transcription factor nit-2, forming part of a system controlling nitrogen metabolite repression (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPAEILSELPLRPAPRDIKIPNAMHNEERRHKHSRSSYSEMSPLMSRNNSLTWRPAKRPMPTPDKTIAVINAAGRQAASFIRVATAVGFHVRAQMRNLEGVVATEVSTNPNVTVLQGELYTKETPAESDKGQCVDVTKNGPISGIGVNDALISELFRGAQLAFINTTFYGDEERIGMALADAAKKAGVQHYVYSSMPDHHAYNKDWPSLPLWASKHRVEDYVKEIGIPATFVYTGIYNNNFTSLPYPLFCTDLQPDGSWIWQAPFHPNAKLPWLDAEHDVGPAILQIFKDGVKKWGGGKRIALAYEMLTPLEACEVFSRGVGRPVRYVRGPIEVKVKIPEGYRIQLEALEELFNLHNEDPEKQPPYFGDIELERSCPRAALELWEGPRGLEEYAREVFPLEEQANGLTWMIEEYDGGGGNNIGNNHNNHHQQEEHYQHQNGHQNGHNGINGHIVNGGVDSESEEEDSDSDDEGLVMRGNKRADEEWLA
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.
Sequence:
MESSKELLEKLLTDEVLDSLIQDTACLQTLKPLLEVKHERIIGGQCEKITLSLNSLYDSDVDVDLAAEILKRALYVTRDNTLLSQTQSFCLSKLQSSRSLDELYYCCNLLNVLFEYYKSEKLALMEWKSDEFSNGILNTLVASSKPLFTFVTIYLLPNYFTVCSRNNKNLFLENAFKFIRDNKRLDFLCVLWAHFIPVDLTSNNFNVLKVDEFWKLVIESLSTQSQKQAIYLLSKSTEIAFKPENIPHIPNYLKVENESEIEKIWRNYFTLLDVSNEKQLHFIEPSLHMLGSIKHLQIEWRLCLYKILLNHSQTSVVYSVANFIIENENVWQDFSKILENLLHAVNKHECNEQSKSVFRKIGIYCSKLNEFQFQQFLVDCMNPAWTPSALWGLFSNIFTDEMNFQISFELFSKIIKKIKVLPHKFIRESCTRIVFQHFIRNHTLESVDDVFKISILLYDFNEALFRDFITKNAQNILNFKDELCDKFQACDEWVEIKVRIFQILKIKIPVFPVTPTQQNDLIFGFLLEDVETSVLEKYVISRIESVLETDDISALLNILLKFTTPKLCENAEIILSRQQYNPSQKIIALGILKQNRNSITFCKNLGKKSDPLTTSIVKILLNSLHDNSSEITDCINFFEAVFDKQSNATITILENISVILKFIDRDFVFDFFILCLNEFLNLHKSGNFRTTASVFLKQIFEAQFFENGRFCNAIFDFVKKLLPLANTANSVTYCLAKMIRSVCQQNPQMGLIFVPVIAELILHGIVISKNERVEYNVCQEIYSKLGKIENNPNFEEMSVRLTALDTMLDLINNPSLETEVVVSQFVSVLIEKYNEYFSKRYFPDSLIHFQKLRIMQTLLLLHEHIKAEKTPLVNLLIKSFLLESHQPSVKHLMQWLLISLLQTDSDVFIQTINNNLKSVNNNRPSTTSGFIPILYNLVTLQREAQWEQVTEMLLPYTMGPQFKLRIFSQVALVKLYEKAKDKRLDSFTEKYKILYNSLKQVLAATNSVYDSDTIQHEFLDFINLSQCDCSTIFYLIPRKNAVSATEWENLKTVSDWEHFKFISFNHSDNNIQETYAPITTHTIASDNIQKKITPWKDFLSTSPSQENNFILVTTLIEKSTNLGGLSRTCEVFGIKQIVMRTAKIISDKEFKSLSMSSENSVEILEVKPEDLASFILNMKAQGYSVVGAEQTSESVKLDAFRFDKKTVLVLGNEKEGIPPDLIPLLDHCIEIPQFGLVRSLNVHVAGAIVIWEYCKQHRL
The following text describes a protein:
Function:
Part of a regulatory network that coordinates tolerance to the antitubercular drug bedaquiline.
Domain:
Contains an N-terminal HTH arsR-type DNA-binding domain and a C-terminal rhodanese-like domain.
Sequence:
MAGQSDRKAALLDQVARVGKALANGRRLQILDLLAQGERAVEAIATATGMNLTTASANLQALKSGGLVEARREGTRQYYRIAGEDVARLFALVQVVADEHLADVAVAAADVLGSPEDAITRAELLRRREAGEVTLVDVRPHEEYQAGHIPGAINIPIAELADRLAELTGDRDIVAYCRGAYCVMAPDAVRIARDAGREVKRLDDGMLEWRLAGLPVDEGAPVGHGD
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MARRLLAAVAIVVVAAALACGAGAQLSAGFYSSSCPAVHSIVRQAMSQAVTNNTRSAAAVLRVFFHDCFVNVSKSDHALLIRSIYYSTVLYVIRWPFVFPPCCRAATPRCCWTTRPRRPARRAPAPTPAAPPSASTSSTPSRRRSRPPAPPPSPAPTSWRSPRATASTCTGAATDLPGPDSDLAGLVAGFAAKGLSPRDLAALSGAHTVGMARCASFRTRVYCDDNVSPAFAAQQRQACPSADADDALAPLDSLTPDQFDNGYYRSLMAGAGLLHSDQELFSNGALDSLVRLYGTNADAFSSDFAASMVKLGNIGPLTGSAGETRRPNRSGQHCGVRPWADHSRHHPVTVRILAGKTSVPARRARQA
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MPRAIKGVLIECDPSVKAIILKYDEESHDYIVEDLDDDRHLVIKESQLQNLKERLGRELDEKVMQPEESESE
The following text describes a protein:
Function:
Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate (By similarity). Interacts with DDX3X; this interaction enhances CSNK1D kinase activity in vitro, but it is unclear whether this interaction is physiologically relevant (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
XIFPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNL
The following text describes a protein:
Function:
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MMEHVVKDAVNIGAVVQGTLLLLTGTLMLILLHRIFGVKNWRNQSALPGPGWWLGLGPVLSYSRFLWMGIGTACNYYNEKYGSIARVWINGEETVILSKQVSSAVYHVLKSNNYTGRFASAKGLQCIGMFEQGIIFNSNIAKWKKVRTYFTKALTGPGLQKSVEVCVSATNRQLDVLQEFTDASGHVDVLNLLRCIVVDVSNRLFLRIPLNEKELLIKIHRYFSTWQTVLIQPDIFFKLDFVYRKYHLAAKELQDEMGKLVEQKRQAINNTEKLDEMDFATELIFAQNHDELSVDDVRQCVLEMVIAAPDTLSISLFFMLLLLKQNSAVEEQIVQEIQSQIGSRDVESADLQKLNVLERFIKESLRYHPVVDFIMRQSLEDDYIDGYRVAKGTNLILNIGRMHKTEFFKKPNEFSLENFENTVPSRYFQPFGCGPRACVGKHIAMVMTKAILVTMLSRFTVCPRHGCTISTIRQTNNLSMQPVEEDPDCLAMRFIPRAQNSNGETADNRTSKE
The following text describes a protein:
Function:
Putative aminopeptidase which plays a role in oocyte maturation.
Sequence:
MRRKLLLLLCFIGLFSLISTAPAPNNVGLESEFTEGHAETINLEEVEFNHPSILPEHPDNFRQDKLAARKRQSLYVTKTRLPPNLYAIDYSLWFQPYFPSPGVQYAPEKNFTFDGRASIQVEALVASDRFILNAYNFKIQSYKVVDIDGTVVPINSISQDDTTQQLSLITNANGVVAGQIYNIEFVYTGIINPYTDGGVYYTSYNDPQGNTHYMIATHMEPFSARKVFPSLDEPSYKAKFTITVQYPASQVALSNMMETEPTKIDNIWSTITFPQTPKMSSYLIAFAVGPYVNSQYVNKHNTLTRAWGWPGTEQYLQFAAQNAGECLYQLGEYTGIKFPLSKADQLGMPEFLAGAMENWGLIIYKYQYIAYNPTTMTTRNMEAAAKVMCHELAHQWFGDLVTTAWWDDLFLNEGFADYFMTFIQKSVYPQQATYLDTLQVLDELQVGLTADVRYDAHPLVYPDGPAFDDITYNKGASMLRMLSDVLGADVFKQGIRAYLQKMQYSNANDFDLFSTLTDTAKSNNILDWCGLPLNVTDFMQPYIHQTNHPLIRYNNNQKIGGSTFSQEPFLDISDLTATPWNYTWSIPLTSANLRHADPYKQWLPRQQGCANMNENIQEERIKEPNKRAVQWELTSITSATYGRIIYDDIGFDRILKLIKQDDINDNLKLTLLADEYNYMLREKKANRPFGYNRFLDLAKVIFNTQSFTNYPSYGVFAQAQPVLEQIAQLYRDGIDAEFVPRLYKLFFQNSYNQLKWQDTSIWDTDTFSEVFLPFAVRYDIGDVQNRTLNMFANVKSACINSLNGTAWCNPYSTNLRKAIYCGAAKYAPATSDYFFQMLHSYNKEVITNPYFYQEYMALLEGMSCTQSPATLKVLIRLFTTSTLNPSTIFGFLKYNPAASDVLYNYFMANPQLVNSTMLDAYLDAMTYNWNSYFREGQLSTLMNTLTLTNDQFDIFDFYINRVSLMFEYKSTYALPTYNWLYDNLVVIGKTPWEKTPNIDAVFPYYKLDLQVNIPGSGPYQWYENMTFSATSTVTFQLVSPTSSITINAHRLMFDPVSIRLYNENDENAHTPIPIDFSKVMKDYDKGTVTIPTMNNTVLYPNQYSLFIEYTGFIFQNPDEGDASNTYLGGLNNRKGWIFTTDFEGGPGARSLLPCWDEPSYKGQFEVSVFHPTDMIALSNEVDIQRTIYDNGWTTTKFATTNQMSTYLLALCVGHFSNLATVTRTGVLTRVWTWSGMEQYGEFALNVTAGTIDFMENYFSYDFPLKKLDVMALPEYTMNAGAMENWGLIIGEYSLFMFDPDYATTRDITEVAETTAHEVVHQWFGDIVTLDWWNDIFLNEGFAQYWFANGIDNTFPEQHAYSIDYNRFYMNHIALKYDCIPGVAKPVISDTPPVFGIEPYYKGSALLNLLNNVLTPAVFQEGLSSYLTQYGYVNASPRNLWTSLTVAAQRHNITDWNGQPLDVSSFMDPYTLQTSYPIITLTLRGTSTVQANQQSCMSDETLWNVPLFTQTPGALDFNWFVNFTGGNDATWLRPLPTGYRVDNAGSTSFARINYDDKSWYSIQAQLLSNMNTMSSTTRAMLLDDANFFYQSGRWEMTKFLDLTLYLVNEDSLAPWEQAIEFFTEMLNRFQYQPEIDTVRNYVIQITKNAVSKFQWNTNGLWANDRIVQLLVNVNNLAVNRQSRQVALTLFNNFVLKCKYSLSGTGKCSGIHPNLRQPTYCYGLRQSNNIDDFTTVNNLYSWFVQNAGYLQTDGSNLLNALGCVQNLDLQKTMLRSILSGDYPPSLLNSIAVHDDSSDVLYNFLLDNTQDILNAPFDFSLYVKAMFQNWSTSNQLELAKDFQNSSNYNLLNAAQKNIYKQGILTVNSNANWMLIYKTPFLEWIQKNFGAPNL
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MVYPPTDGQRVTVLSIDGGGVQGIVPAVLLNFLEHQLKELERENGGNADDVRIADYFDVIGGTGTGSLLAAMLTKPSKQQPIRPQYDMSDIISSLKEISRDTFPDEEALSLVQRAVNLASGAFGLFTSTLRTFLDPQKNIWSIIDEFWERNWETDCRPVEVYNEKLRIKLGNTRLDETLSDVVIPAFCFDTSRPVVFSTSQLHEKCNEDVTLTDAVLSSSATPTVFPFHSFKYLGRFGRFADGSIFANNPTLLSLTEGANLHGSGPNYNNHLVLSLGTIRRRAPPNDICALPSVIIDYISNKIWKGIRSRVLQYMYILFGDITEMYMTQMLPSQLHEGCLNYLRIQGFEPNNLVPSIVDGSESGFETLRRAANNIFKRPATVVDPNTGTHAEQNFTNEQALTYFAQQLHIERQRRLLNE