lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids.
Sequence:
MSLKAVVFDAYGTLYDIQSVADITEDAFPGYGEIITQVWRIKQLEYTWLRSLMQRYQDFDAVTRDSLAYTLRILGLAYEREEFERVIEKYLHLDLYPDATSALAALKPRQLAILSNGSPDMLNGLVRNTKLDRLLDATISVDAKKVFKPSPAAYELIGEVLGTAPDEVLFVSSNPWDVAGAKSYGLNVAWIERVTPEAMALACVENELVAPLTMFKAIRTQMDELGFAPDHRVRALSELPSII
The following text describes a protein:
Function:
Cleaves internal linkages in 1,3-beta-glucan.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MRFQVIVAAATITMITSYIPGVASQSTSDGDDLFVPVSNFDPKSIFPEIKHPFEPMYANTENGKIVPTNSWISNLFYPSADNLAPTTPDPYTLRLLDGYGGNPGLTIRQPSAKVLGSYPPTNDVPYTDAGYMINSVVVDLRLTSSEWSDVVPDRQVTDWDHLSANLRLSTPQDSNSYIDFPIVRGMAYITANYNNLTPQFLSQHAIISVEADEKKSDDNTSTFSGRKFKITMNDDPTSTFIIYSLGDKPLELRKQDNSNLVASKPYTGVIRVAKLPAPEFETLLDASRAVWPTGGDISARSDDNNGASYTIKWKTNSNEAPLLTYAYAHHLTSIDDSNVKRTDMTLQSATKGPMTALVGNEWTLRETELSPVEWLPLQAAPNPTTINEIMTEINKDIASNYTQETAKEDNYFSGKGLQKFAMLALILNKSDQTQLRNPELAQIALDKLKAAFLPYLQNEQADPFRYDTLYKGIVAKAGLPTSMGGTDDLSAEFGHSYYSDHHYHQGYFVVTAAIIHHLDPTWNADRLKAWTEALIRDVNNANDGDEYFAAFRNWDWFAGHSWAGGIKPDGALDGRDQESVPESVNFYWGAKLWGLATGNTPLTKLASLQLAVTKRTTYEYFWMLDGNKNRPENIVRNKVIGIYFEQKTDYTTYFGRFLEYIHGIQQLPMTPELMEYIRTPEFVSQEWDEKLGAIAPTVQSPWAGVLYLNYAIINPAEAYPALRKVQMDDGQTRSYSLYLTATRPHFFRRSLLAALARHGSTRRPSLPSSGDDDKHEDGFLLRFRRLNPFNLKHRIY
The following text describes a protein:
Function:
O-acyltransferase that catalyzes D-alanylation of both teichoic acid and lipoteichoic acid (LTA). D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Catalyzes D-alanylation from DltC carrier protein.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTAYGSFYFFAIVGILLIPTIIAGLKGKMLRKYNAVLTLVMLAIIFSDKPKQAMMLAAFIIWQYVLIKGYLILRKQNNSTFTFCIAVILSILPLILAKIAPFASFLPELKLVVFLGISYVTFRAVQMVFEVRDGLIKELSFFNFWEFVLFFPAISTGPIDRYRRFQKDIQKPPSAEEYQNLLYTGLNRIFQGFLYKFIIAYLIKQYCMDPAFAQHDTIFSNMIYMYSYSLYLFFDFAGYSSFVIGVSYMMGIKTPENFNKPFLSRNIKDFWNRWHMSLSFWFRDFIYMRFVFFATKKKLIKNRYTISYIGALLNFFIMGIWHIQGSAVAQYVIYGLYHAALFILFDIFERKNKKHKFWPNNKFTHILAIVITFHVVCFGFLIFSGHLNRYF
The following text describes a protein:
Function:
The H protein shuttles the methylamine group of glycine from the P protein to the T protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST).
Subcellular Localization:
Mitochondrion.
Sequence:
MALVRALLCTLHAVPLPAAPCPPRPWQLGVGTVRTLRTGPALLWVRKFTEKHECVTTENGIGTVGISNLAQEALGDVVYYSLPEVGTKLNKQDEFGALESVKAAGELCSPLSGEVTEINEALAENPGLVNKSCYEDGWQIKMTLSNPSELDELMSEEAYEKYIKSIEE
The following text describes a protein:
Function:
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MITIVLLILAYLLGSIPSGLWIGQVFFQINLREHGSGNTGTTNTFRILGKKAGMATFVIDFFKGTLATLLPIIFHLQGVSPLIFGLLAVIGHTFPIFAGFKGGKAVATSAGVIFGFAPIFCLYLAIIFFGALYLGSMISLSSVTASIAAVIGVLLFPLFGFILSNYDSLFIAIILALASLIIIRHKDNIARIKNKTENLVPWGLNLTHQDPKK
The following text describes a protein:
Function:
Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step. Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules. Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Nucleus. Cytoplasm. Note=Localized to the base of the connecting cilium between the basal body and the adjacent daughter centriole of the cilium. In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid.
Domain:
The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding; Arg-186 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate-chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation.
Sequence:
MPIVMARDLEETASSSEDEEVISQEDHPCIMWTGGCRRIPVLVFHADAILTKDNNIRVIGERYHLSYKIVRTDSRLVRSILTAHGFHEVHPSSTDYNLMWTGSHLKPFLLRTLSEAQKVNHFPRSYELTRKDRLYKNIIRMQHTHGFKAFHILPQTFLLPAEYAEFCNSYSKDRGPWIVKPVASSRGRGVYLINNPNQISLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVRYDQGAKNIRNQFMHLTNYSVNKKSGDYVSCDDPEVEDYGNKWSMSAMLRYLKQEGRDTTALMAHVEDLIIKTIISAELAIATACKTFVPHRSSCFELYGFDVLIDSTLKPWLLEVNLSPSLACDAPLDLKIKASMISDMFTVVGFVCQDPAQRASTRPIYPTFESSRRNPFQKPQRCRPLSASDAEMKNLVGSAREKGPGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRMTADGAPELKIESLNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKTETESEEEEEVALDNEDEEQEASQEESAGFLRENQAKYTPSLTALVENTPKENSMKVREWNNKGGHCCKLETQELEPKFNLMQILQDNGNLSKMQARIAFSAYLQHVQIRLMKDSGGQTFSASWAAKEDEQMELVVRFLKRASNNLQHSLRMVLPSRRLALLERRRILAHQLGDFIIVYNKETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQASEAELEEVLTFYTQKNKSASVFLGTHSKISKNNNNYSDSGAKGDHPETIMEEVKIKPPKQQQTTEIHSDKLSRFTTSAEKEAKLVYSNSSSGPTATLQKIPNTHLSSVTTSDLSPGPCHHSSLSQIPSAIPSMPHQPTILLNTVSASASPCLHPGAQNIPSPTGLPRCRSGSHTIGPFSSFQSAAHIYSQKLSRPSSAKAGSCYLNKHHSGIAKTQKEGEDASLYSKRYNQSMVTAELQRLAEKQAARQYSPSSHINLLTQQVTNLNLATGIINRSSASAPPTLRPIISPSGPTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSNLWTMNNGAGCRISSATASGQKPTTLPQKVVPPPSSCASLVPKPPPNHEQVLRRATSQKASKGSSAEGQLNGLQSSLNPAAFVPITSSTDPAHTKI
The following text describes a protein:
Function:
Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus. Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L. Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN. Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1. Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP.
Sequence:
MFFRLCRHINTCKQQFFTICVKSYRYQMIASEADPAEWKERGVGDVNILQHKTDQGKIRVLMRRDKTIKICANHYITPHMEFKLNCGSDRALFWNVTADFADEEPKAELLAIRFANAENASDFKSKFDEAKDQVRERDLKQKERKRQTVEQSREKKRIPTRLPRSSGNLPSLMAKNLERRMLRQQEQKAEETKKEEPEDKMKDMSHRLL
The following text describes a protein:
Function:
Binds citrate- or chloride-dependent Fe(3+); part of the binding-protein-dependent transport system CbrABCD for uptake of the siderophore achromobactin.
Subcellular Localization:
Periplasm.
Sequence:
MNEYLVSRRRLLRLSLSLLPLGLGRPALAQSLFMPQRVITLFQGATDTAVALGITPAGVVDSWSEKPMYRYLRQALAGVPHVGLETQPSLEDIVLLKPDAIVASRFRHQRLEPLLSQIAPVVMLDEIYQFKKTVQVMGQALQRQAVADQLLQNWQLRVNGLREQLQRKFGGDWPPTVSILDIREDHIRSYLPGSFPGSVLSELGFGWSDASRAQPGVSLKLTNKESIPVVDADIFFIFLRSESPSVQRNYESLIRHPLWQQLRAPRRNQVWVVNGVTWSLSGGILGANMMLDDIARVTGIAGGVS
The following text describes a protein:
Function:
Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.
Sequence:
MNFARTERRKSMAERRPSTVYTPPVIPHLAGLEKPQDQYLKMDNCDVLIIGTGLQESILAAALSWQGTQVLHIDSNTYYGDSCSTLTIEQLKKWCGDVNSGKIHQFQDAQIYIPGGKQSNQYTSKDYGIDLTPKIMFCQSDLLSLLIKSRVYRYLEFQSLSNFHVFENDDFQQKVNATTKQDIFTDKSLSLMTKRYLMKFLKFLLLDPDYKQRVKPYADTPIQVFLQQEFKLEEPQINELVYSIGLSYKEQTSTKQALIRMKRFLSSFDVYGKFPCMVSKFGGPGELSQGFCRSAAVAGTTYKLNTNLTDFDPISKIAHFNDGSHIKINEKIIISPTQLPKFLQSSYNKVVENLQPYYVTRLVTVVRRDCKEWMSGNESSAIVVFPPHSLPTDNQHSVQVIIQNGNSGVCPDGQAIWFSSTVEQDLSRAKVDLESAFEKMETSLLRESSEEIVNDILGDNNNNNNNDFVMNAQGTTTPVLVNSFKLGSSLINFVPKDKLEIVCKLGYVEKTFINPDLSNIFKPTKTNNIVYKDVEDANNEIIFTNMPSSELSYDGIITDVKSIYQRITGTTDDFFDVDFEDEEDEYDRNNQPVVQPKRSSVVGGIVGGGSITSLTALREQHNENNHSDNAIDSDEDEDEDINDMNDMNDNEEEDDHGRGPEPFGADEMEL
The following text describes a protein:
Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSGADRYLTVFSAEGRLWQVEYSFKAVKQAEVTAVAVKSKNAVCVAVQKKVSDKLIDPSTVTHMYRITDNVGACLVGLPSDVNFIVMLLRSFANNFEYKQGFSIPVSILAQMLSERHQLESQLVYVRPSAVSAILFGLDGPSDSFALYKIEPSGYSNGFRAVACGVKEIEAMSALEKKMEDFETPEATAEFTLSTLQTVCGVDFEAQDVEVSLLTRDNSKFSKLPNDKVNEILHAVAEKD
The following text describes a protein:
Function:
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MHVRDLERTFTRQALERLGGWRNITDLLEDLVESGKVIRTRKKTYGLPEAMSLVRGRFQASAAGFGFVVPDSNMGKGGGEDYYIPQDRTLEAWNGDTVLVRMDGRGDSRSDRDGGRDNGRGGRRGQKGDGNPRATVVRIVQRAYKQLVGTLEFSHGHPILKPDDFRARHRILLLPEGLEELEAGARVVTELFWPEHTGEDEVFGQVVRVLGAEDDPETETEAVIVKFGLRGEFPDDVQEQANAIPGEIPEEALVGRLDLREFNIFTVDGRDAKDFDDAIHIQPTPEGNFVVGVHIADVSHYVQEGTPLDGEAYARATSVYLPGRVLPMLPEHLSNGVCSLVPYQDRLTMTALVELSAEGDILDVKLSPSVINSKARLTYDEVQAYSEATATLPDHARHLEGDLHLLLKITTKCARSAARRLTRLQVREVKVDVDKDGRMELIPIREETARGMIEDLMLLANKVVAHYLIEREIPTLFRIHEEPTLQKFQDVTGAIGRLGFSFPGGEPTPQAYQAVLKQVRGTGRESVVNTLLLRSMQQAKYAGENLGHFGLAFDEYLHFTSPIRRYPDLVVHRTLKKVLSGDFKAGNREVAQFQGRLPSMGEHTSDRERTAAEAERDLTKYYQCKWAQEHRGESFMGNVSGVVSSGLYVALDNGVEGKLHISHLDDDYYIFIEDAQILKGRSNGKSFRLGDAVQVTISDVKPLARQIDLTLADPEDPDYTPGSYDLPAAAQETPMTDVKVRARRRRTASRSGRKNSRAFP
The following text describes a protein:
Function:
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalization.
Sequence:
MARLGFQRQGTQLDLASRTWSCAALFSLLFLPVFSKALHVSQPAVVLASSRGVASFVCEYASSHKATEVRVTVLRQANSQMTEVCAMTYTVENELTFIDDSTCTGISHGNKVNLTIQGLSAMDTGLYICKVELMYPPPYYVGMGNGTQIYVIEPEPCPDSDFLLWILAAISSGLFFYSFLITAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN
The following text describes a protein:
Function:
ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway.
Subcellular Localization:
Cytoplasm. Nucleus envelope. Note=Diffused localization, with some punctate distribution, especially in the perinuclear area. Localizes to the nucleus envelope during late anaphase.
Sequence:
MSVSVEKRSAWFPPDWDDDERMSFLFSAFKENRDVDCTDWDGKIDFWSPLIIEHCRRCGSVCVNLQDLNENFRRKGSVPLGLSTVIQSMIRSGKVQKESDFAANVDSGWLSWGVGLLLVRPLKWTLSALLGSGRVPLEESFVVIELVKEKAAELLAAYRGSALSARSLLSFQELRSLSSHICPDESTLCMALLQLQREKHVTVSLHEGEKLVKFSQAGQGRVSPVSEVDLGIYQLQCSEKLLEERVEALGHEAEKCKQQAKSLLKEGKKSQALRCLRGSKRVEKKADRLFAQLETVKGILDRIANSQTDRLVMQAYQAGVAALRISLKGVTVERAENLVDQIQELCDTQDEVNQTLASGAPDAGEDSEDLEEELKSLMEKSVPENDLFPAVPTHPITPPRKTDLPDAAFVQFLPSVPNPGMNITDEELDRELRRLTVSDKGLPRESVSPQRRLEPAQ
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
Sequence:
MEGIIVINKPKGITSFDVIRKLKKFLKTKKIGHTGTLDPLAIGVMLVCVGKATKLASDLEAKDKVYIADFDIGYATDTYDIEGKKIAENIIEVSKENLEQSLKKFIGNIKQVPPMYSAIKIDGNKLYHLARKGIEVERPERDITIEYINLLDFKDNKAKIETKVSKGCYIRSLIYDIGQDLGTYATMTALQRKQVGEYSLENSYSLEQIEEMTLNNNFKFLKTIEEIFSYDKYNLQTEKEFILYKNGNTVKIKENLENKKYRIYFQDEFIGLANIENNNLLKGYKYY
The following text describes a protein:
Function:
May operate as a cation/H(+) antiporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MATEEIDMSYWDVSWGEFNEDKNSSIFCESHPHIVNSHGIWEVMTFKRGMNFWEYPLPNLEILIFSTFFIWRLLDISFNKIGLRVPRFTYMMIAGIILGQTCHFSNKSWIHDIFFPDDNRPKVAETLGAFGFVLYWFLKGVTMDAELPFRTEKRSSVIGFITVIIPLICGSLTFRYRERRGDSSILRMEYRLIIFLQSISAFTSIDTLLKDLQIKHSEFGRIALSGAMVTDMLAFGVTFFNAIYYEKLYGFMQTVGFCLFVVVMICVVRPAMYWVIKQTPEGRPVKDFYLYSIFGIAFACFTFFNKVIHLFGPAGSFVFGLTVPNGYPLGTTLIQKFESFNLGSILPLFGSLTMMQVDLLRLFKESGDLIRMEGQIYEVISFILLVNTTKFVVTTITAYAFKMPLRDSFALALVLSNKGIFELAYYTYAVELKLIRPEVFTILAAYTLLNSIFIPMLLELVHDPTKRFRCYRKRNLGILKDGAALQCLMCVYRPDHITSMTDLLETFSPSQDSPMACNILHLVELVGQANPMFISHQLQKPEPGSTSLSDNVIISFRGFQRQFFEYTSLDIFTSVSVSQHMHEDICWLALSRSLSLIVLPFHRTWSVDRSTVISNDDNLRMLNVNVLRRAPCSVGIFVYRKPIVESHMAKSHSKICLIFNGGKDDREALAITNRMRLTEKRTRLTIIRFIPKSSEMDNDEWEQQQSINLKESVTSIVGSNIKENDAKVTYIDKAVSDGSETSRILRAMANDYDLFIVGSGSGIGTEATSGISEWTEFNELGPIGDLLASHEYPSSASVLVVQKQVYIHHTKSQRRKSF
The following text describes a protein:
Function:
Converts the prephenate produced from the shikimate-chorismate pathway into phenylalanine.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
CEAIPCDQFEVAFQAVELWIADRAVLPVENSLGGSIHRNYDLLLRHRLHIVGEVQLPVHHCLLALPGVRKEYLTRVISHPQALAQCELTLTKLGLNVAREAVDDTAGAAEYIAANNLRDTAAIASARAADLYGLQILAEGIQDDSSNVTRFVMLAREPIIPRTDRPFKTSIVFAHHEGTSVLFKVLSAFAFRNISLTKIESRPHRNRPIRVVDDANVGTAKHFEYMFYVDFEASMADVRAQNALAEVQEFTSFLRVLGSYPMDMTPWCPSRED
The following text describes a protein:
Function:
Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing. Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation. Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells. Required for NLRP3 activation induced by viral dsRNA and bacterial RNA. In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways.
Subcellular Localization:
Inflammasome. Nucleus, nucleolus.
Sequence:
MPLAKRQTPPASSSSSSLSSSSSSSSSSSGIDSQRRALPIFQARGALLGQLRSLESAILIGETGSGKTTQIPQYLYEGGIGRQGIVAVTQPRRVAAISLASRVADEKKTELGKLVGYSVRFEELCSEETKIKFLTDGMLLREALGDPLLHKYSVVVLDEAHERSLPTEVLFGVAKGAQRRRKEAGKAPLKVIVMSATMDVDLFSQYFNGAPVLYLEGRQHPIQIFYAKQPQSDYLQAALVTIFQIHQEAPASQDILVFLTGQEEIEAMTKTCRDIAKHLPDGTPQMVAMPLYASLPYSQQMRVFQAAPKGYRKVILSTNIAETSITIPGIKYVVDTGMVKAKRYTPESGLEVLAVQRISKAQAWQRAGRAGREDSGLCYRLYTEEEFEKFEKMTVPEIQRCNLASVVLHLLALRVPNVLTFDFMSKPSPEALQSAAEHLVLLGAVDRKDEQLLLTPLGRKMAAFPLEPKFAKTLLTAPRFHCTEEALTVVSLLSVDSVLHNPPSRREEAQAARRKFLSSEGDLLTLLNVYRAFKSVSGNREWCKENFVNSRNMMLVSDVRAQLRDICIKLSVPLESCRSDTSALRRCLAHSLFLQSAELQPDGSYAASEARQPAAIHPSSALFHSRPACLVYTELLHTSKCYMRGLCPVDPEWLFDAAPEYFRRRLRAPKS
The following text describes a protein:
Function:
Metalloprotease.
Subcellular Localization:
Secreted.
Sequence:
MTSSLVLILAPLALVAIGEAAFGNSSKIFEIPGLEVMASDKYPHFTTIETVSRTKVHRHRREVIAGQIYDWNSYEIPFQIWGGDYNFQSLIRRGIRMWEDSTCLRFKENQQSRDAIRYVLEKGDSCFTEYIGRNGGHQDIIIGSECAEEYVVAHETGHALGFWHTHQRPDRDRHISINWKNVMEEATASFMPFRSMLQAFGIRQVSPRRVPYDYGSLMHYHAVAHAVKVSDFTIVPKELKYVTTMGTEKMAFLDAKVINDIYCPNACQGRNHLNCLAGGYPDPNNCNVCRCPEGLGGPDCGRLQPSPCGGEIHASDQWQTLSSPSGRDVHCYWRISVPEGSRVRFRLSDGEFPCSYGCQSYVEIKHKLDVRLTGFRSCCYRPKEDTVSESNQIFVIYHPNGRTARFSLRFRRQA
The following text describes a protein:
Function:
Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Subcellular Localization:
Mitochondrion.
Sequence:
MHALLGDLASQAPAFPINGDNIKVLSSPSEYFEALLEGITKARYRIVLASLYLGTDEMEQRLADAVGEAAAANPELQVTLLFDALRGTRPTGGKDGTPTSTADLICKSVLSKAGSWVKASLYHTPELSGFWKRFLPARYNETVGIMHLKAYVFDDTTLMSGANLSTSYFTDRQDRYMLLKDCPALASYLTGLVDTVSHFSYPLEPDGTLGPPPCGVDPITDPERFKQTAGNAVRDFVKTAADVSKEPLTPPGEHSVSPSKKSLRERLESDWTASGGLLLDRTAADTWVLPTVQMGPLGVRQDERATLSFFRRLPRHSLVHLASAYFNLAAPYEEALLEALHESLRVKIVTAAPTANGFYGSRGPSGLIPGAYSLMEQRLYERAGGDHQAGLEIFEYSREGWTFHAKGLWLSLAAEDGRASENGRALQNGSVSRTGHMSQNGSVLQHGSVSQNGSASQNGNVSPKGGSSSAPCLTTIGSPNFGFRSLDKDLECQLWLLTSHAELREQLRHERDRLFEQSAHVSQSTFEAGERKPTLLVKVAAALSKGHL
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body.
Sequence:
MPKKKKKSGSGKKGKKGKLAKMTEEERIVYLEQQALAEEEMRKKKEDMLTQYLKDKLTKEEKFTRFNLNKINNQWRAIMRESKSKELRRDIEILSQTFERVVDRKDSVIQSLAKDIAEAEEQFAMALRSHLENVDALIDLQRQRLSTLQSEYDTELEILKKEFDTERDLIVAQHKKEMTDLQDVMFAMEQNFQDREAEARQEFQSMRDEIKNKNLEEKHALRIQLEGAVEDLWRQFQQALKSYNESTEERKVAFENLKAKDEKSAKEIEMQMRKLQRISDQIAQLKAKMAQNSRECDERNHQIKNEREVILQHFHALKDRMNSMRDRERARLTKLTLQSNSAIKELQRVHDKGERILKLSEMCRKLETEEEKVLPFYASSLTEEEQQDVEAAVGEPPSEPLAEVMHEYVSLENFWKRYNKVLLDKLALEKERAGLMTENNQLRTLLKQYLDGISVNDEILSQVNPLFVVNHRTNVKLSVPVVDPRVRRPGQTVVEAAHVVKHNTMGGLLKRDMV
The following text describes a protein:
Function:
Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA.
Subcellular Localization:
Nucleus.
Sequence:
MDIRRFFGAAPGATKTKPVQKTASSAKEKGGVKKSSQTKRKAAVIYDSDSDEEVPPVKQQKTAAAKSAKPNKTEVKSPPSRKQFDPKPVLKPTSAADFFGAASPTHRVSRTTVVAKKRSGHDAGKANDVDSEADKELHDDEAFMETLAELDKSRKKSATMSISPDNKKKENGTHEKKPTKTRVDQTSPKKTREKSPTSSASPKKASPQKSKYFDKTEDQKMKKKIKLESQDKDEAKPDQPKKAKKPSPVKTKTEKTPSPKKSPAKDSNQDAEKKPARGAYRAYLTREGPRALGTKEIPQGEENCLGGLTFVLTGILESMERHEAKELVERYGGKVTSSVSKRTSYVVVGRDAGESKLDKVSQLGLKTLDEDGLLELVKTLPGKPYDLPPEATSKSKKSPPKKSPNKPEPAATTRKPVASSSRVESPKKPAASLTTTDSPEPSLLWVDKYKPQTTKAIIGQQGDRSNVKKLLKWLQAWPKHHSGRQVKEDGSGFRAALLSGPPGVGKTTAATLCCQELGFTYIELNASDTRSKRSLQEEVSEALTTRSIVGFQKQEDAGTMRQAVIMDEVDGMAGNEDRGGIAELINLIKHTKVPIVCMCNDRSHQKMRSLVNYCFDLRFQRPRVEQIRAAMMSMAFKEGLKIPPPALNQIIEATNHDVRQVIHQLYMWSVQDKALTFDQAKEASKQAQKDIKQGPFEVTRKVFSSGEDTARMTIMDKSDLFFNDYSMMPLFVQENYPNVLPNAARNNMKKQLSLLSQTADSICDGDLVDKLIRSRQSWGLLPTQAIYASVLPGEYMRGHLSGMISFPGWLGQFSKQNRLRRLLQELHMHMHLRTSCTKKSLQEDYLDPLRRRILNLLVTQETEGVPEAVELLSAYDLMREDYDGMLELTEFKGRPNLAEKVNSKVKSAFTRAYNKEAHMQPYSTSAAPKKKRGGAANSMDMEDGGEGGALEESDEEKEDPKLDPMIKMKKPTAAKGKSDSEKGKGRGKGRGKKSS
The following text describes a protein:
Function:
Plays an essential role in neuronal cell migration.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized specifically to the pericentriolar region.
Sequence:
MWGRFLAPEASGRDSPGGARSFPAGPDYSSAWLPANESLWQATTVPSNHRNNHIRRHSIASDSGDTGIGTSCSDSVEDHSTSSGTLSFKPSQSLITLPTAHVMPSNSSASISKLRESLTPDGSKWSTSLMQTLGNHSRGEQDSSLDMKDFRPLRKWSSLSKLTAPDNCGQGGTVCREESRNGLEKIGKAKALTSQLRTIGPSCLHDSMEMLRLEDKEINKKRSSTLDCKYKFESCSKEDFRASSSTLRRQPVDMTYSALPESKPIMTSSEAFEPPKYLMLGQQAVGGVPIQPSVRTQMWLTEQLRTNPLEGRNTEDSYSLAPWQQQQIEDFRQGSETPMQVLTGSSRQSYSPGYQDFSKWESMLKIKEGLLRQKEIVIDRQKQQITHLHERIRDNELRAQHAMLGHYVNCEDSYVASLQPQYENTSLQTPFSEESVSHSQQGEFEQKLASTEKEVLQLNEFLKQRLSLFSEEKKKLEEKLKTRDRYISSLKKKCQKESEQNKEKQRRIETLEKYLADLPTLDDVQSQSLQLQILEEKNKNLQEALIDTEKKLEEIKKQCQDKETQLICQKKKEKELVTTVQSLQQKVERCLEDGIRLPMLDAKQLQNENDNLRQQNETASKIIDSQQDEIDRMILEIQSMQGKLSKEKLTTQKMMEELEKKERNVQRLTKALLENQRQTDETCSLLDQGQEPDQSRQQTVLSKRPLFDLTVIDQLFKEMSCCLFDLKALCSILNQRAQGKEPNLSLLLGIRSMNCSAEETENDHSTETLTKKLSDVCQLRRDIDELRTTISDRYAQDMGDNCITQ
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.
Sequence:
MAANGAQQGFEPVLAAHNMMQSAGNRAQKEQAHQFLEQFQKSQEAWVTTLAIIESPAADAAAKLFAATTLKGKIVYDLHQVPRAQLPELRASIMRNLATFHAGPKPIRLQLCVCLANLAIQMTEWKDVLSDVVTALGSDPATLPCVLDFLRVLPEEVTHGRKIALTNNSLMLGGQEHELTMRTVELIEDNAQQALQLLIRYATSSPAAARNPQLLNCITSWMREIPLESIINSPLLKIIADDLSETTDEPFDAAVECMSALIAETRDVDETMQSILTLYPQVIALRPKLAQAAQEEDTDKFKGIAKVFAEAGESWVLLIARLPTDFRNLVEAILEAAALDKERDAISHTFKFWYDLKQYLTIEKYGEARMQSLDIYSKLVDIMIGHLEFPKPESGDEKDLFEGDREAEEKFREFRHQMGDVLKDCCEVMGVVECLQKPYDLIQRWVQTYGQQAGPNNVPEWQKLEAPLFAVRAMGRMVPPDEDVMLPRLIPLIAAIPDHNKLRFQAVMALGRYTEWTAQHPDTKLYLDPVMQHLVTIAQQAKDEPEQKLLADKINLITIFVETVRPEIPSGQEHPAVKYCQEIFPMLGNIIEHFNKSIPILERFYEQQAKTFLRILSDLPPEELPDLIEDYFRLAADMALYFPSESISSPLMETILLAACSSLTLLKEDPIIATLHFLRDLLAYGRNSSPSSSFETARQEVPEALRNRVKQLVVGAGVQLVQRIMTGMMYSFPEGAFADSSGVLLDLFELMPEQVAQWVANTVNMLPQGSITPQESERFLNNIRQRIQTGDVRMIRTILQDFTTSYRRRNVAPREGLGRLEASRFRFSG
The following text describes a protein:
Function:
Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.
Miscellaneous:
MISCELLANEOUS: Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MGSRPRGALSLLLLLLALLSRPASGCPAPCSCAGTLVDCGRRGLTWASLPAAFPPDTTELVLTGNNLTALPPGLLDALPALRAAHLGANPWRCDCRLLPLRAWLAGRPERAPYRDLRCVAPPALRGRLLPYVAEDELRAACAPGLLCWGALVAQLALLVLGLLHALLLALLLGRLRRLRARARARSIQEFSLTAPLVAESARGGAS