lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAGELGQQTVELGSVVRRAAEESYLALRDLVEKSQAESDWKGAYGGRQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVQYCQQLGSTLSSHETCFTQTADSLFFMHEGLQQARAPTFDVPSALEVMLTGSYQRLPRCIEDIGSQNKLSPDEEKHALQKLDTSVRYKVLVTPRPKEVSSISVTDGVAVFRVDGEFKVLLTLGYRGNLDLWRILHMELLVGEKNGPIKLGEIRRFALGDDIERRMAVSENPFSVLYAILHELSISLAMDTIIRQANVLRHGRWKEAISSERISDSTTGQTGNAAVMQLGQDGEFDSSGFRLPVLKLNYWLDGKNSGPAESDLSPFIKIEAGQDMQIKCQHSSFILDPLTDKEANLSLDLSCIDVEKLILKAIACNRHTRLLDIQRQLCKNVQISQSPKDVVLKRDVGVAKAPHKKTEKASFADFCGNEVLQVRAYGQAYIVLGVNIRSGRFILQSPKNILPPSALVDWEEALNKGSNTATEVFSSLRTRSILHLLVSTGSFFGLKVYEQSQGTLKIPEAILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDASNKLNANIGAKEAMRVNKIDVGQMEKIKYEKNSNPFDAKLHSLQSIENCDDMMDNQLLIQNSVDPLPLLPACSPSFSSIVDETFECEHGSSLPSASPVRSLSLGPQGASTRTISQMQDGALSHAQANNTSIVCPGVGVNSYFQNSLSHLQSTNAFLSSNPVRNSSAIKLSNSKSNHDLSSLSSPSEHGIADGNKPFQLAPSSTLPAHLVRSSPAIEGLGKAITLGADCAPRKRSLSDFLLDLPSLQGLKSSEPSKRRKISESAQSSLPLQAYSSSSQSGTSLTHGNNILAERNNCVPATVYASVLLHVIRHCSLCIKHAQLTAQMYSSAIPYVEEVGMRSPSSNIWFRLPFAQDDSWKHICLRLGKAGSMSWDVRINDPHFKELWELNGGSTSTPWGVGVRIANTSEMDSHISFDVDGVVLTYSTVEADSVKRLVSDLQRLANARVFARGMRRLIGVKLDDKLDDNHISVGMKSQSVNKGHSDADRLSEHMGKPFRIEAVGLMSFWFSYGHMPMVHFVVEWETAKEGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSTGYSSMPKQTNNVPSQGPLANGSSATTMHHASAPSNATAHLGGHTLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPAFMNATQPGPHLNTSAGAPQSAPVANRLNATPGVAMSRPTSSVANHVAASLSRAGNAMLSSSGLASGIGGASVRLTPGTGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELTSAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLITWKKGFSQAHGDIATAQRARIELCLENHSGSASDDRTESSLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLRYSFGDNSHISFLAINGSHGGRACWQQSEDWERCKQKVARAVETVNGTPAVAEPGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSTLIHFLGHWLLKFFAKMGILTVVKLLEKGIYNTKIYDLLVDFYSKNGDLEAAFHRLNEMNNRKLDASFCTYSSVLDGACKYNDSEVMERITRIMIEKQLLPRCQFSGNDSIIQKLCDLRKTHAAEMMFKKACGKNIRLQDETYGSLLKAMSQVGRIDEAINMYQTMLKRGIKVKDSCYCAFANVLCKEDQSGDGYGLLVNIMKQGHHPCPSQLSKYIASLCRRKKWKKAEELLNLMLKKGLLPDSVPCCLLMEYYCFNREMDKVVALHYEMVKVEGSLDVTTYNTILEGLWREKKAEEAVGVFDYMTGLNLVNSASFTIMICELCRMKEMRKAMKIHDEMLKMGFKPDKGTYKRLISGFK
The following text describes a protein:
Function:
Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs). Plays a role in protecting dopaminergic neurons from oxidative stress-induced degeneration.
Sequence:
MTTNGFDPFEWRSFYFPGMSREEAHKLLGEPQVSIGTFLMRDSSRPGEYSLTVREADEGNAVCHYLIERGEPKEDGTAAAGVKIANQSFPDIPALLNHFKMRVLTEASLLAAYKKPIIEVVVGTFKFTGERETDLPFEQGERLEILSKTNQDWWEARNALGTTGLVPANYVQIQMEFHNDRTSKGASQSSIGSSGGGAERFSSASTSSDNIELQPRLPAKAKVTFDRVPNAYDPTQLRVKKGQTVLVTQKMSNGMYKAELDGQIGSVPHTYLRFTAVSE
The following text describes a protein:
Function:
Plant-specific TFIIB-related protein involved in the regulation of endosperm proliferation during the syncytial phase of endosperm development. Does not contribute to RNA polymerase IV or V activities in reproductive tissues.
Subcellular Localization:
Nucleus.
Sequence:
MEEETCLDCKRPTIMVVDHSSGDTICSECGLVLEAHIIEYSQEWRTFASDDNHSDRDPNRVGAATNPFLKSGDLVTIIEKPKETASSVLSKDDISTLFRAHNQVKNHEEDLIKQAFEEIQRMTDALDLDIVINSRACEIVSKYDGHANTKLRRGKKLNAICAASVSTACRELQLSRTLKEIAEVANGVDKKDIRKESLVIKRVLESHQTSVSASQAIINTGELVRRFCSKLDISQREIMAIPEAVEKAENFDIRRNPKSVLAAIIFMISHISQTNRKPIREIGIVAEVVENTIKNSVKDMYPYALKIIPNWYACESDIIKRLDGVITSWDSAKFSV
The following text describes a protein:
Function:
Acts as an E3 ligase mediating SUMO/Smt3 attachment to SMC5 and YKU70. Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
Miscellaneous:
MISCELLANEOUS: Present with 2800 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MALNDNPIPKSVPLHPKSGKYFHNLHARDLSNIYQQCYKQIDETINQLVDSTSPSTIGIEEQVADITSTYKLLSTYESESNSFDEHIKDLKKNFKQSSDACPQIDLSTWDKYRTGELTAPKLSELYLNMPTPEPATMVNNTDTLKILKVLPYIWNDPTCVIPDLQNPADEDDLQIEGGKIELTCPITCKPYEAPLISRKCNHVFDRDGIQNYLQGYTTRDCPQAACSQVVSMRDFVRDPIMELRCKIAKMKESQEQDKRSSQAIDVL
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MTQQDLPQNQRFNNLDNCTDSLRQSIKILQQSNKILDETLQDSTRLTKILSTNKVFDLIPELDLNDAKSNFTKNITPQLNQQLNKLEDELIQLQTKKTTLTNKLKLINVRLKNYEKKGNKEEGGKNFNSNGLSDIDIDNLLTNRHKNGYDVNKLHQLRFLRDKKTRLQYSLNRLN
The following text describes a protein:
Function:
Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSQSVGFEWGFKAGGEGRPRAQGDGAGCAGATAAANSQQGCGHLVHMSYKVGKPKMKRRLTNEEHGGARRAKRQPAQFNVIQGQPLPVHRKIEMMDKAALQLTLLQLVAMHPEVQDSLSVLQPTSPDPAKYTELLEQKMQAVYDHIPYSKSSDMLNDYAFVRMKAAILEFLNCLIDCLLDAIPPRTTNLLQSFKFLAYGTRLLAQMPHFETESNNYYKNICYEQVSEIWNTLIRHASSDINFLSTKPSLLHYLHELKQFNEQTKGKFDIPLRLFYTIMDDYHTQTVPAAAAVASTSATVAEELNGNSKSMETLGIWNNVA
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MVFFSRVSSPKLCGSVVIIARKQQQCVITVGQRSISGKVMRQGLPPVKKPAPFPYKEKRYNFLRALFDPTTSRLDENSKLIVVEGPPAAGKRALAKELAEELDMAYFPSPNVADCYINKYGYDLRQVDHKLPESCKSYDENDFLKDPMRGNGSKAARFQLTKLSLRYKLHLEALAHILNTGQGVVMDRSPFSDLAYMTAMTETGIISKNVYNFYHQVRNNALFALWRPHLVIYLDVPVDETRRRIEARNLPNEKDSMLTTPAYLQALVDSYKKDYLKDISTHAEVLVYDWSKVADPEIVVEDIERIDFDQYTVYDEKMKDWRRINEWDWNNSRQEFTHSQHYLMAHLNVPPIQCNEILIGAGDNKVRAGVMDETPGCKFAKGFNPEMGDKGILFKLS
The following text describes a protein:
Function:
Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MLVSSLVMRSRCASTTTTVSTISWTEFFAMRKNKKLVERTVGGLGGVFGLSLGSYYFLFVAEFDPFQQIWGLDPSMPYMLGAFSTGIVSAVAGSLGANQLWRLMRNPSMLRAFDLKEKEFHQRILRHRPKELPLFTTASPTRPPTPPDYYGEHIYSFSGYRKWIRRQRKFIAATAESSPK
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSSATETLSNFKEATLSILSTRHPWSEFLSFSTLSLPSSFSEATTRVGINLTRFLFNYTFIFLFILLISLVYHPLAIVLLLIAFAGWYFLFFSRDSDEPLSLFNVVAVDDRVVVVALVVFSLFVVWVSGVWVNVVVSVLVAAGIVCLHGALKRTDVGGLDDYESPYGPMLATDTAGPYAPV
The following text describes a protein:
Function:
A humoral factor that may play a role in stress tolerance. Requires Mekk1 expression in the fat body to regulate response to septic injury and consequent immune response (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MNPAIYLSCLVVFSLLLLGKVNAEDDDEFRTEKQRLLRVYGDSSVDEATRYRNVDDLVKFYDKYSTLLPWKPDLTQRAQDLLRRYKEETARAVLVDGAPAQGGFWLPLVKLLIVQLGVEIASEGFKRAIES
The following text describes a protein:
Function:
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Subcellular Localization:
Secreted.
Sequence:
MNAHVLLLCTILFLLVHTPPVLGGMKEKCVTMGGYCRKQCRVQDALSGYCRNENPCCVRRVLMEDG
The following text describes a protein:
Function:
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQQTRCRPNILVSGTPGCGKSTTCELLQRHLPDYQYFNISDFAREHNCYDGYDEARKSHIVDEDRLLDELEPLLRRGGAIVDWHVNDIFPERLIDLVVVLRCDNAILHDRLQKRGYHSSKIEENIDAEIMGVVLQDALDSYVREIVVELQSDDTEQMQQNVDRIAAWEANWVSEHPDGVSNALQQHAGSDASSSEADSDGVSDAGDSDGDGDGDSTQDN
The following text describes a protein:
Function:
Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.
Subcellular Localization:
Lipid droplet. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Membrane associated on endosomes. Detected in the envelope and the core of lipid bodies and in lipid sails.
Sequence:
MSADGAEADGSTQVTVEEPVQQPSVVDRVASMPLISSTCDMVSAAYASTKESYPHVKTVCDAAEKGVRTLTAAAVSGAQPILSKLEPQIASASEYAHRGLDKLEENLPILQQPTERVLADTKELVSSKVSGAQEMVSSAKDTVATQLSEAVDATRGAVQSGVDKTKSVVTGGVQSVMGSRLGQMVLSGVDTVLGKSGEWADNHLPLTDAELARIATSLDGFDVASVQQQRQEQSYFVRLGSLSERLRQHAYEHSLGKLRATKQRAQEALLQLSQALSLMETVKEGVDQKLVEGQEKLHQMWLSWNQKQLQGPEKEPPKPEQVESRALTMFRDIAQQLQATCTSLGSSIQGLPTNVKDQVQQARRQVEDLQATFSSIHSFQDLSSSILAQSRERVASAREALDHMVEYVAQNTPVTWLVGPFAPGITEKAPEEKK
The following text describes a protein:
Function:
Required specifically for plant innate immunity. Is essential for resistance conferred by multiple R genes recognizing different bacterial and oomycete pathogen isolates like avirulent P.syringae or H.parasitica (downy mildew). Contributes additively with SGT1B to RPP5-dependent resistance. Functions as a positive regulator of RPS5 accumulation by assisting its stabilization. May function as co-chaperone of HSP90-2 to positively regulate the steady-state accumulation of RPM1 and protect it from SGT1-mediated degradation. Acts as a negative regulator of pathogen-associated molecular pattern (PAMP)-triggered immunity.
Domain:
The 2 cysteine and histidine-rich (CHORD) domains bind each 2 zinc ions, and the plant-specific 20 amino acid cysteine and histidine-containing motif (CCCH motif), located between the two CHORDs, binds 1 zinc ion.
Sequence:
MEVGSATKKLQCQRIGCNAMFTDDDNPQGSCQFHASGPFFHDGMKEWSCCKQRSHDFSLFLEIPGCKTGKHTTEKPVLAKSVPKHPVAAPTSSPDANAATKDSCSRCRQGFFCSDHGSQPKEQIKQTLNTPGQAEEEKIEPLAPPVQKAVIDINQPQVCKNKGCGQTFKERDNHETACSHHPGPAVFHDRLRGWKCCDVHVKEFDEFMEIPPCTKGWHSSSPDPAV
The following text describes a protein:
Function:
VirB proteins are suggested to act at the bacterial surface and there play an important role in directing T-DNA transfer to plant cells.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MKGSEYALLVARETLAEHYKEVEAFQTARAKSARRLSKVIAAVATIAVLGNVAQAFTIATMVPLIRLVPVYLWIRPDGTVDSEVSVSRLPATQEEAVVNASLWEYVRLRESYDADTAQYAYDLVSNFSAPMVRQNYQQFFNYPNPTSPQVILGKHGRLEVEHIASNDVTPGVQQIRYKRTLIVDGKMPMASTWTATVRYEKVTSLPGRLRLTNPGGLVVTSYQTSEDTVSNAGHSEP
The following text describes a protein:
Function:
Ubiquitin receptor that limits final seed and organ size by restricting the period of cell proliferation. May act maternally to control seed mass. Acts synergistically with DA2 to regulate seed size. Functions synergistically with DA2 to restrict cell proliferation in the maternal integuments of ovules and developing seeds. Functions antagonistically in a common pathway with UBP15 to regulate seed size. Associates physically with UBP15 and modulates the stability of UBP15, which promote cell proliferation in the integuments of ovules and developing seeds. Functions as a peptidase and cleaves the N-terminal sequence of E3 ubiquitin-protein ligases BB and DA2 in a ubiquitin-dependent manner. Cleaves the deubiquitinating enzyme UBP15, which promotes cell proliferation, and the transcription factors TCP15 and TCP22, which promote cell proliferation and repress endoreduplication. Involved in the promotion of leaf senescence, in addition to its function in restricting plant growth. Acts redundantly with DAR1 and DAR2 to regulate endoreduplication during leaf development. Together with DAR1 and DAR2, modulates the protein stability of the transcription factors TCP14 and TCP15, which repress endoreduplication by directly regulating the expression of cell-cycle genes.
Miscellaneous:
MISCELLANEOUS: 'Da' means 'large' in Chinese. Plants overexpressing DA1 exhibit early senescence.
Domain:
The UIM domains bind molecules modified by monoubiquitin or ubiquitin chains and promote coupled monoubiquitination.
Sequence:
MGWFNKIFKGSNQRLRVGNNKHNHNVYYDNYPTASHDDEPSAADTDADNDEPHHTQEPSTSEDNTSNDQENEDIDRAIALSLLEENQEQTSISGKYSMPVDEDEQLARALQESMVVGNSPRHKSGSTYDNGNAYGAGDLYGNGHMYGGGNVYANGDIYYPRPITFQMDFRICAGCNMEIGHGRFLNCLNSLWHPECFRCYGCSQPISEYEFSTSGNYPFHKACYRERYHPKCDVCSHFIPTNHAGLIEYRAHPFWVQKYCPSHEHDATPRCCSCERMEPRNTRYVELNDGRKLCLECLDSAVMDTMQCQPLYLQIQNFYEGLNMKVEQEVPLLLVERQALNEAREGEKNGHYHMPETRGLCLSEEQTVSTVRKRSKHGTGKWAGNITEPYKLTRQCEVTAILILFGLPRLLTGSILAHEMMHAWMRLKGFRTLSQDVEEGICQVMAHKWLDAELAAGSTNSNAASSSSSSQGLKKGPRSQYERKLGEFFKHQIESDASPVYGDGFRAGRLAVHKYGLRKTLEHIQMTGRFPV
The following text describes a protein:
Function:
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation. Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis; (Microbial infection) Regulates the formation of the NLRC4 inflammasome triggered by Anaplasma phagocytophilum infection; (Microbial infection) Protects against Klebsiella pneumoniae infection. Attenuates bacteria-induced pulmonary inflammation and promotes intro-abdominal pathogen clearance. Promotes anti-inflammatory responses by facilitating TLR4 internalization and translocation into early endosomal membranes; this leads to activation of TRAM-dependent endosomal signaling and release of anti-inflammatory cytokines; (Microbial infection) Promotes macrophage phagocytic efficiency towards Cryptococcus neoformans and ability to control fungal infection inside the cells; (Microbial infection) Contributes to protection against Pseudomonas aeruginosa infection by regulating autophagy via the AKT1-mTOR-ULK1/2 signaling pathway and activation of Rho GTPases via FAM13A-mediated mechanism.
Miscellaneous:
MISCELLANEOUS: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane; Early endosome. Note=(Microbial infection) In lipopolysaccharide (LPS)-triggered macrophages, aggregates as clusters along the cytoplasmic side of the membrane, shows substantially enhanced co-localization with TLR4 signalosome complex and gets recruited to early endosomes.
Domain:
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence:
MSTVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIETAVKTKGVDEVTIVNILTNRSNVQRQDIAFAYQRRTKKELPSALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAGADDLKVLGMWTSPFVIRVRIVLNLKGLAYEYVEEDLGNKSALLLSSNPVHKTVPVLLHAGRPVNKSQIILQYIDKVWAGTGPAVLSRDPYERVVALEGGFSSASVRVCPHGTEDEAPRKKARLGWGQGLTKYEKQKVQGPVDPAEAIADGSPADGELKTASLATKEKSKEIDRLAREQKAEERQKQRGKESDVEAGIEIPEERGLGSMTIIVIVSMSKVVEKTNPMIRERERIKAPKQSL
The following text describes a protein:
Function:
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.
Subcellular Localization:
Endosome, multivesicular body. Extracellular vesicle. Secreted, extracellular space, extracellular matrix.
Sequence:
MKLLWALFAVALLAGCQADPLPLDQDLGLGAGNTQQPWEETVERFWSYVVQVQNMAYDMHDKAVNSQINKEINSLLEDTATEFNALKEQLEPAVEDTRARVHKELTAVVDRLQGDLQEAKERVTQYETEIQAMVGQNVEELRSRTASQLRKLRKRITKDAEELRRRITVYGTGAREGMERGVGVFRERLEPIGQRIQAKGQERVQVMGELVSQQVKDLGSKVQGYGEQVKEKIQELQGQVRGRLMKAGEDTRDKLDDLKEKLEEMKEKVEQQANEVREQLEKIQEQLRSWFQPLVQDVQTQWSNLLEKVQGIKEPVPEE
The following text describes a protein:
Function:
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Sequence:
MSWTPCDAGLTEFSPSSVVLTPDPPVIGSPATFVISGDIGNELPGGSVDMTVSFSGLPIYSSTSDLCTKTTCPVPAGPIAITIVQVLPPIAPPGDYGLQVVARGPDGSELACVNVAFSLVLPSAVSGAAGSHGAVGRKQRMGSRQVA
The following text describes a protein:
Function:
Could coordinate an aspect of bone turnover.
Subcellular Localization:
Secreted.
Sequence:
MISRMEKMTMMMKILIMFALGMNYWSCSGFPVYDYDPSSLRDALSASVVKVNSQSLSPYLFRAFRSSLKRVEVLDENNLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVSTAVCRSTVKVSAQQVQGVHARCSWSSSTSESYSSEEMIFGDMLGSHKWRNNYLFGLISDESISEQFYDRSLGIMRRVLPPGNRRYPNHRHRARINTDFE
The following text describes a protein:
Function:
Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation modifying cytidine to N4-acetylcytidine (ac4C).
Sequence:
MHATKKKKTRVILRMLPVSGTCKAFVDDMKQYSETFFEPWFKSPQKGTFQIVYKARNNSHLSREKVITELAGVVGHLNPENKVDLNNPEFTIVVEIIKNICCLSVVKDYVLFRKYNLQEVVKSGKTDCQGDASKASPEGNSKGDKAVVENVGSQDQPEDKFEEKANDNHED
The following text describes a protein:
Function:
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
Sequence:
MGKSKNRVVKPKRRDKPPRQKDVEEEKEEEEVEDSEDADDESTSEPGSDEDATSSEEEEYDFPFRLAMYDFNQCDPKRCSGRKLLRADLITEVKLGQRFPGLVLSPTGKYTLAPRDRPFVEQHGLCVVDCSWKEVERTPLHKVKAPEHRLLPYLVAANSVNYGKPCHLTCAEAMAAGLYILGFREAAHRLMKPFTWGEHFIELNKELLELYAACNTPEEVIKAQNEYLERIDKEREEHSRDIDLPPSSSEEEETEEEAEFLFVLVLVIHLVDSLINSVFFCSLNSKISDFKRFSAIEYIFLPSFVQFASYWLFRSLKMPEIEEEMDFETTTEEGFGYELNDILYQGAEAKVTKCVWLGREAVIKERFSKGYRHPTLDTRLNKARTKQEIRGMWKARQLGVLVPTVYFIDAEKNQLILEYIKGPTAKYWISQLSSDEYDEKMREFGAVLGANLAKLHLGGLVHGDLTTSNMILKNGELSRLTFIDFGLSSQGKVTPEEKGVDLYVLERAVVSTHENSKALLEGLMEGYKKVNEKQFTAVEKKLEEIRLRGRKREMIG
The following text describes a protein:
Function:
May play a role in embryogenesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAVTISTNAFVNASLLDESRNSFWRPLFHQPYYNCRRVVRLNSRKLNSKVMFCLNLNTKEVGLQKPGDKGFEFKPSFDQYLQIMESVKTARKKKKFDRLKVEEDDGGGGNGDSVYEVKDMKIKSGELKDETFRKRYSRQEIVSDKRNERVFKRNGEIENHRVATDLKWSKSGESSVALKLSKSGESSVTVPEDESFRKRYSKQEYHRSSDTSRGIERGSRGDELDLVVEERRVQRIAKDARWSKSRESSVAVKWSNSGESSVTMPKDESFRRRYSKQEHHRSSDTSRGIARGSKGDELELVVEERRVQRIAKDVRWSKSDESLVPVSEDESFRRGNPKQEMVRYQRVSDTSRGIERGSKGDGLDLLAEERRIERLANERHEIRSSKLSGTRRIGAKRNDDDDDSLFAMETPAFRFSDESSDIVDKPATSRVEMEDRIEKLAKVLNGADINMPEWQFSKAIRSAKIRYTDYTVMRLIHFLGKLGNWRRVLQVIEWLQRQDRYKSNKIRIIYTTALNVLGKSRRPVEALNVFHAMLLQISSYPDMVAYRSIAVTLGQAGHIKELFYVIDTMRSPPKKKFKPTTLEKWDPRLEPDVVVYNAVLNACVQRKQWEGAFWVLQQLKQRGQKPSPVTYGLIMEVMLACEKYNLVHEFFRKMQKSSIPNALAYRVLVNTLWKEGKSDEAVHTVEDMESRGIVGSAALYYDLARCLCSAGRCNEGLNMVNFVNPVVLKLIENLIYKADLVHTIQFQLKKICRVANKPLVVTYTGLIQACVDSGNIKNAAYIFDQMKKVCSPNLVTCNIMLKAYLQGGLFEEARELFQKMSEDGNHIKNSSDFESRVLPDTYTFNTMLDTCAEQEKWDDFGYAYREMLRHGYHFNAKRHLRMVLEASRAGKEEVMEATWEHMRRSNRIPPSPLIKERFFRKLEKGDHISAISSLADLNGKIEETELRAFSTSAWSRVLSRFEQDSVLRLMDDVNRRLGSRSESSDSVLGNLLSSCKDYLKTRTHNL
The following text describes a protein:
Function:
Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein.
Sequence:
MSRALTSSIFLLALLFHLSYWQALGDERFEEAYSNLVEGLKEIMVDWNETLPKLPGFECYKNRPIGAPALGKNLEFPCTVTMPSDEIPTSVHRLRPADINVIGAMGDSLSAANGAGACFLPELALEYRGLTFSHGGDEGFETNPTLANVLRKFNPALKGYGWGTGRWDSDEAGMNVGYPGDKANDMPHQADWLIEKMKADPNIDYENDWKVVTLFIGGNDLCAWCKNIVYYASDNYVNFIHESLMTLHDQMPRTIVNVVGLLQVYQVEILSSTICDFIHQGVCSCGMFLTPDELAEFEAMNRQYQVKLTEDINSGQYDDKDDFTVVLQPFLQETAVPMTEDGDPDFSYFAPDCFHFSAKGHAQCGIELWNNMIEPVGNKRVTWDPTVTDISCPTEEFPYIYTNLNSQPEYWEATTPAPPAEGGASITHFSRVFVFCLLCIIDLLRD