lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Disease resistance protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. The interaction with TIP (TCV-interacting protein) may be essential for the recognition of the avirulence proteins, and the triggering of the defense response. Triggers resistance to turnip crinkle virus (TCV) via a SAG101-dependent pathway.
Miscellaneous:
MISCELLANEOUS: In cv. Columbia and cv. Landsberg erecta, RPP8 specifically recognizes the Emco5 avirulence protein from Hyaloperonospora parasitica, while it is not the case in cv. Di-17, where it confers resistance to Turnip Crinkle Virus upon recognition of the viral capsid protein; MISCELLANEOUS: [Isoform 2]: Has been shown to exist only in cv. Columbia so far.
Subcellular Localization:
Cell membrane.
Domain:
The LRR repeats probably act as specificity determinant of pathogen recognition.
Sequence:
MAEAFVSFGLEKLWDLLSRESERLQGIDGQLDGLKRQLRSLQSLLKDADAKKHGSDRVRNFLEDVKDLVFDAEDIIESYVLNKLSGKGKGVKKHVRRLACFLTDRHKVASDIEGITKRISEVIGEMQSFGIQQIIDGGRSLSLQERQRVQREIRQTYPDSSESDLVGVEQSVKELVGHLVENDVHQVVSIAGMGGIGKTTLARQVFHHDLVRRHFDGFAWVCVSQQFTQKHVWQRILQELQPHDGDILQMDEYALQRKLFQLLEAGRYLVVLDDVWKKEDWDVIKAVFPRKRGWKMLLTSRNEGVGIHADPTCLTFRASILNPEESWKLCERIVFPRRDETEVRLDEEMEAMGKEMVTHCGGLPLAVKALGGLLANKHTVPEWKRVFDNIGSQIVGGSWLDDNSLNSVYRILSLSYEDLPTHLKHCFLNLAHFPEDSEISTYSLFYYWAAEGIYDGSTIEDSGEYYLEELVRRNLVIADDNYLSWQSKYCQMHDMMREVCLSKAKEENFLQIIIDPTCTSTINAQSPSRSRRLSIHSGKAFHILGHKNKTKVRSLIVPRFEEDYWIRSASVFHNLTLLRVLDLSWVKFEGGKLPCSIGGLIHLRYLSLYEAKVSHLPSTMRNLKLLLYLNLRVDTEEPIHVPNVLKEMIQLRYLSLPLKMDDKTKLELGDLVNLEYLYGFSTQHSSVTDLLRMTKLRYLAVSLSERCNFETLSSSLRELRNLETLNFLFSLETYMVDYMGEFVLDHFIHLKQLGLAVRMSKIPDQHQFPPHLVHLFLIYCGMEEDPMPILEKLLHLKSVRLARKAFLGSRMVCSKGGFPQLCVIEISKESELEEWIVEEGSMPCLRTLTIDDCKKLKELPDGLKYITSLKELKIEGMKREWKEKLVPGGEDYYKVQHIPDVQFINCDQ
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MLWKCEFVFLVLHSSGIHRTSAMNQEDSSRRAATLSTARSPTFFTHTDIQAQLQNLLLSSSSISSTLSIDNEHLDQLAAIIRNIHLSKQQDAFLNHLNKFIIQKEAEIEAVSRGHYQDFLGSVDKLLSVRQGTISLKSHVVSLDASLQTSGTSLATVRSSLLDARKVSTNIQETIETLQSCLKVLDLSKKLSQQISERKFYSALRSLDELQFVHLKPLLGFAAFAGYLGEALPNEKIRIREEVTKQLNSWLYDARQQSQQLGRLALEALELRDRRWKARKDRLNTQDTASMALLVNLNTPVEIAVSERHDYHVLDSGDGSLIDFGPLYLAIHIHETLDAREELQKSFRDDRRAQAHLILASMSSNSGGSSAFTLDSLGALIEQIAGFFIIEAQILRTTKAFRDENDVDSLWEELSDRIVCIVRLGLTNCSDLDLLMGVKARLLSFSQALESYNYTVAQFHELLSSLSTEYIDLLFKKFSVEFEQFIQEDDHQPMLVHNADEFSKVVEVSFLPNHGIWTKAELAKQTFPTALPFSQAYPLCCIHIRNYVTNHYAYCESITRDADDSIRKCLDSLLISHVGLHMFSQINLTKNLSQLAQIVINTLFFLTACEGLEAILVQLRVSARFISPELEAKAMFKKLLKTGEQKILGEIQEKIQDFFELSEYDWRRKTAIEPGDQTDDGGGRVNEQETSVYLKECLSFIDTLIDNVLVLTPVDFNENIFFGAWMFIGQRLKSFLIDREPAAISDGGLSVLMNDIHFASHRLRKSPFSSSASNTSSSPISLEVHKFFRELVQTVNLLASPDVGKYLDLDYRAMKYDLVRSESLPLMLVKLLTCMNSVGSNVDPIRKSSVQEVLKALSP
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MANASETNVGPMAPRVCVVGSVNMDLTFVVDALPRPGETVLAASLTRTPGGKGANQAVAAARAGAQVQFSGAFGDDPAAAQLRAHLRANAVGLDRTVTVPGPSGTAIIVVDASAENTVLVAPGANAHLTPVPSAVANCDVLLTQLEIPVATALAAARAAQSADAVVMVNASPAGQDRSSLQDLAAIADVVIANEHEANDWPSPPTHFVITLGVRGARYVGADGVFEVPAPTVTPVDTAGAGDVFAGVLAANWPRNPGSPAERLRALRRACAAGALATLVSGVGDCAPAAAAIDAALRANRHNGS
The following text describes a protein:
Function:
Recruited co-dependently with zhp-3 to the synaptonemal complex between homologous chromosome pairs to regulate the formation and number of crossover events between homologs during meiotic recombination. In the early stages of pachytene, in complex with zhp-4, recruited by the zhp-1-zhp-2 heterodimer to designated crossover sites along the recombination intermediate to stabilize other pro-crossover factors such as rmh-1, msh-5 and cosa-1. This in turn facilitates crossover and promotes the formation of chiasma in each meiotic nucleus at the late pachytene stage of meiosis. Negatively regulates double strand break formation to promote formation of the crossover intermediate.
Subcellular Localization:
Chromosome. Note=Co-localizes with zhp-3 to chromosomes from mitosis to early diakinesis in the germline. Co-localizes with syp-1, a component of the synaptonemal complex from early prophase to mid-pachytene. At late pachytene, localization at chromosomes is not dependent on syp-1. From mid-pachytene, co-localizes with cosa-1 at crossover sites of recombination intermediates, and gradually disassociates from syp-1 along both chromosome arms.
Sequence:
MEAVHCFRCYKFPSKQIEFYLTNCMHMFCIECERLCHPPEEEPLKCIQCSKTPIRIVKMGPELPMTIKSMFTPISEEINQYTRDLTRVLTFQHRQRASLSTFLERKVAAFDRLRDAYSEEKTKKEHYKKQLEEAYHLLKSKEHEISKLKKQLAEQAPPPQTPPRSNSLKVASSRSLETPSMMRVFSDSMYETPVQIQRRFTKAQAKAEAEAEAPAKSPGSKAQTTKCTSNYQSHPPASFETPIHHPPKTSMGFTTPANPPHMFPYLKKHEAQREKHKEHRNSQ
The following text describes a protein:
Function:
May be involved in vacuolar protein sorting.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MNRILSSASLLSNVSMPRQNKHKITKALCYAIIVASIGSIQFGYHLSELNAPQQVLSCSEFDIPMEGYPYDRTWLGKRGYKQCIPLNDEQIGIVTSVFCIGGILGSYFATSLANIYGRKFSSLINCTLNIVGSLIIFNSNSYRGLIIGRILVGISCGSLIVIIPLFIKEVAPSGWEGLLGSMTQICIRLGVLLTQGIALPLTDSYRWRWILFGSFLIAVLNFFMWFIVDESPKWLLAHGRVTDAKLSLCKLRGVTFDEAAQEIQDWQLQIESGDPLIEPTTTNSISGSNSLWKYLRDRTNVKSRHVITVLLFGQQFCGINSIVLYGTKIISQLYPQHAIRINFFISMVNVLVTILVSLLIHSLPRKPLLMTSTVLVSVTAFIMGIAMNHNKMNLLIVFSFIYMGVFTMGLNPLPFIIMREVSKPQDMVLAQRYGTICNWVGTFIIAYTFPIIHDVLSGYVFIIFAIIACSISAFIWKKVPETKRSG
The following text describes a protein:
Function:
May be directly involved in signal transduction and/or cell cycle regulation. It is necessary for maintaining growth rate or spore germination. Could show both activity toward tyrosine-protein phosphate as well as with serine-protein phosphate.
Miscellaneous:
MISCELLANEOUS: Present with 7570 molecules/cell in log phase SD medium.
Sequence:
MAGNANSVDEEVTRILGGIYLGGIRPIIDHRPLGAEFNITHILSVIKFQVIPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQCLFPNEVEYSPRLVDFKKKPQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKMGGDFVDFDNPAYKQWKLKQSIKLDPSGSELVSNSGMFKDSESSQDLDKLTEAEKSKVTAVRCKKCRTKLALSTSFIAHDPPSKESSEGHFIKRAANSHRIIDIQESQANCSHFFIEPLKWMQPELQGKQELEGKFSCPGCSSKVGGYNWKGSRCSCGKWVIPAIHLQTSKVDQFPLQSTALPNMVNFESEKVNR
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSDFSMETLKNLRQQTGVGLTKCKEALEHAKGNLEDAVVYLRKLGLASAGKKEHRETKEGVIAARVDERGAALVEVNVETDFVANNNVFRAFVTSLLSDLLDHELSDVDALALVMSSQEPSLSVEELKAVTMQTVGENIRISRAFYTPVNSGQSVGIYSHGNGKAVAIAFLSGSENQEALAKDIAMHIVASQPQFLSKESVPQEVLEREREVFSSQVAGKPQEVVEKITQGKFRAFFQEACLLEQAFIKDPEVTIQGLIDRAAKASGEPLKVEHFVFWKMGA
The following text describes a protein:
Function:
High-affinity iron transporter that plays a key role in the uptake of iron from the rhizosphere across the plasma membrane in the root epidermal layer. Acts as the principal regulator of iron homeostasis in planta. Also mediates the heavy metals uptake under iron-deficiency by its ability to transport cobalt, cadmium, manganese and/or zinc ions.
Miscellaneous:
MISCELLANEOUS: Inhibited by cadmium and Fe(2+) ions and at 100-fold excess inhibited by cobalt, manganese and zinc ions; MISCELLANEOUS: The availability of secondary non-iron metal substrates (Zn, Mn, and Co) controls the localization of IRT1 between the outer polar domain of the plasma membrane and early endosome/trans-Golgi network in root epidermal cells; MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Early endosome. Golgi apparatus, trans-Golgi network. Vacuole. Note=Cycles constitutively between early endosomes and the plasma membrane and is targeted to the vacuole for degradation.
Sequence:
MASNSALLMKTIFLVLIFVSFAISPATSTAPEECGSESANPCVNKAKALPLKVIAIFVILIASMIGVGAPLFSRNVSFLQPDGNIFTIIKCFASGIILGTGFMHVLPDSFEMLSSICLEENPWHKFPFSGFLAMLSGLITLAIDSMATSLYTSKNAVGIMPHGHGHGHGPANDVTLPIKEDDSSNAQLLRYRVIAMVLELGIIVHSVVIGLSLGATSDTCTIKGLIAALCFHQMFEGMGLGGCILQAEYTNMKKFVMAFFFAVTTPFGIALGIALSTVYQDNSPKALITVGLLNACSAGLLIYMALVDLLAAEFMGPKLQGSIKMQFKCLIAALLGCGGMSIIAKWA
The following text describes a protein:
Function:
Major protein kinase C substrate of platelets.
Sequence:
MEPKRIREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQDFGKRMFVLKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEGGQKFARKSTRRSIRLPETIDLGALYLSMKDPEKGIKELNLEKDKKVFNHCLTGSGVIDWLVSNKLVRNRQEGLMISASLLSEGYLQPAGDLSKNAADGIAENPFLDSPDAFYYFPDSGFFCEENSSDDDVILREEFRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGGEDPLGAVHLRGCVVTSVESSHDVKKSDEENLFEIITADEVHYYLQAATSKERTEWIKAIQVASRTGK
The following text describes a protein:
Function:
Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
Subcellular Localization:
Cytoplasm.
Sequence:
MAFTGLNFLKRKKKKSPKYSVMFVCAVNIQRSPMAEAIFYHLVEQRSELNKWDIASSGVSSEATHQQPVSPCTITVLEDNHIKPRLHPSRKLCHDDFKRYRYILCMDEDNLRLAKEKLPHGCKAKVELLGNYDPKGERIVVDPIFDCNDWNAFDPNNPAIIINPRLGNLSDYEHVFQQCWRSCNTFLDFVTGQKA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSRSSPSGKGHSRMAEPRFNNPYFWPPPPTMPSQLDNLVLINKIKEQLMAEKIRPPHLPPTSASSQQPLLVPPAPAESSQAVMSLPKLQQVPGLHPQAVPQPDVALHARPATSTVTGLGLSTRTPSVSTSESSAGAGTGTGTSTPSTPTTTSQSRLIASSPTLISGITSPPLLDSIKTIQGHGLLGPPKSERGRKKIKAENPGGPPVLVVPYPILASGETAKEGKTYRCKVCPLTFFTKSEMQIHSKSHTEAKPHKCPHCSKSFANASYLAQHLRIHLGVKPYHCSYCDKSFRQLSHLQQHTRIHTGDRPYKCPHPGCEKAFTQLSNLQSHQRQHNKDKPYKCPNCYRAYSDSASLQIHLSAHAIKHAKAYCCSMCGRAYTSETYLMKHMSKHTVVEHLVSHHSPQRTESPGIPVRISLI
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MEVGLLQKQLLDLTTTLVKNGFLDKQFMEIQSMSDSSNPDFALDVINDELHKTIEHRFANCKEISDYAHRLKGSSAIVGLKRIADLCKYLRECCDRVDLNGCCSRLQQIKCDLFIMKSELQKIFDMQKQILAAGGSLPKI
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MAAEPKTVTEDAKIDLFEDDDEFEEFEINEEWEEKEEGNEVTQQWEDDWDDDDVNDDFSLQLRRELENNAEKN
The following text describes a protein:
Function:
Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular Localization:
Cytoplasm, cytoskeleton, actin patch.
Sequence:
MTFRTLDVDSITEPVLTEQDIFPIRNETAEQVQAAVSQLIPQARSAIQTGNALQGLKTLLSYVPYGNDVQEVRTQYLNAFVDVLSNIRAADIPAFVKECSTEEIDNIVNFIYRGLANPQAYNSSVLLNWHEKVVEISGIGCIVRVLNSRPDL
The following text describes a protein:
Function:
Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.
Subcellular Localization:
Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus, nuclear pore complex.
Sequence:
MAFNFGGAPSNTAGSSGFSFGSFAPKTTASTGFGFGTATTAASSGFGSLAAPGFGTTTTTASSTGFGFGAANTGFGGLGAANPTTGAFGGFGTTTTSAAAGPTFSFAAPVNTGGLFGNTQNKGFGFSSGFGAGTVATGGLGTGLGTGLGFGGFNTQPQQQGLGGLFGQLAQPPSQSNQLINTASALSAPTLLGDERDAILAKWNQLQAFWGTGKGYFNNNIPPVEFTQENPFCRFKAVGYSCISASKDEDGLVVLAFDKKEVDVRNQQQQLVESLHKLLGGNQTLTVNVEGVKALPDDQTEVIVYVVERSPNGTSKRIPATALFGYLEQPHVKGQLQQLSVVLTVARTELSPAQLKQLLQNPPAGVDPIIWEQAKVDNPDPEKLIPVPMVGFKELIRRLKIQEQMTKQHQTRVDIISDDISELQKNQATTVAKIAQYKRKLMDLSHRVLQVLIKQEIQRKSGYAIQVDEEHLRVQLDTIQSELNAPTQFKGRLNELMSQIRMQNHFGAVRSEERYSVDTDLLREIKQHLKQQQEGISHLISVIKDDLEDIKLIEHGLHDGVHLRGGVLS
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFKTVTREKVFQKFTSSIRMLLIQGQIFGLITFGCSNRCFFPSKIRICWNVLLNCVYLFLCGFCVYEFASDERIKLVIKAIIIMILSGCIIFTEGIWICSLIHRKKIVKFLDGIMAFDIQLKQVVNYKKKKFQRMVVARYVYYATIFTIITATSSFVTIHNVIGQFLGYFIGLITFVMSQHCVELVSMIKARFVVVNQQIGGIVTYFSTNLPKRETEVRKKSLDFGKLCSLHHHLSKLIKSFNEIYGVPLLLFFGLNFLIITQAMFLVVGQLQASQIHWQKIIIIVMSSVTYGIDTVAVCDACYSTIEEATRSGELIHKIETENHDVIDEIEMFSLQIANEQVEFSAAGFFPINYTLIFSIIGGVTTYIIILIQLSTTL
The following text describes a protein:
Function:
G-protein coupled receptor for PDF neuropeptides. Plays a role in responses to environmental signals, including chemicals and touch, and in modulating locomotory behaviors. Capable of transducing signals via an adenylate cyclase acy-1 cAMP-dependent pathway. Required to regulate the sex-specific expression of TGFbeta-like daf-7 in the ASJ chemosensory neurons, perhaps acting via acy-1. Involved in modulating mate searching behavior independent of nutritional status. In the presence of food, plays a role in initiating and extending exploratory roaming behavior, perhaps acting in AIY, RIM, RIA, and other neurons, in opposition to 5-hydroxytryptamine (serotonin) signaling. Involved in mediating arousal from the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity. May play a role in circadian rhythms of locomotor activity; [Isoform a]: G-protein coupled receptor which is activated by neuropeptides PDF-1 and PDF-2. Probably acts through the G-alpha(s) type of G proteins to elevate cAMP levels; [Isoform b]: G-protein coupled receptor which is activated by neuropeptides PDF-1 and PDF-2. Probably acts through the G-alpha(s) type of G proteins to elevate cAMP levels; [Isoform c]: G-protein coupled receptor which is activated by neuropeptides PDF-1 and PDF-2; however, activation is lower compared to isoforms a and b. Probably inhibits cAMP levels through the G-alpha(i/o) type of G proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MADATSPFNVSILDNSTKLSEMVESGWNVLASTSVQAFNEAMDVLEESYPLCKKMLDHNNLFPERDPNDTRIWCNATYDTVLCWPPTPANSSVTLQCPHMKGLDPNKNITKDCHVSGVWSGRNAGEMGPTLPGWTNFTMCYTDEVIYIMQNLNNESLTIAQEVARNARKLEFVGLGLSLVSLILAISIFSYFRRLRVFRNLLHLHLMIAMLMVVILRLVLYIDLIFTGENGPHTNSAEGKTINTMPIVCEGMFFFLEYFKTVTFCWMFLEGIYLNNQIVFGFFNSEPKLLPYFIAGYGIPLVHTMLWLLVVLIKKDFKVERCLGSYYLEPEFWILDGPRMAELVINLFFICNVIRVLYSKVRESNNTSEAGLKKSVKAAMMLLPLLGVPNIMQTIPFAPTRDNIMVFAVWTYTASFTYMYQGLMVASIYCFTNKEVNHVLKTFYARYRLLHKSQNELRRGSRSVASHYAAKNGTANASAPQTNNADEFGKLSPFPSRSKKGSDDSTTKLMKDAVMEEEKNANNNGYGSAGEMTPLREGSNRSTKSP
The following text describes a protein:
Function:
Visual pigments such as rhodopsin and porphyropsin are light-absorbing molecules that mediate vision. Rhodopsin consists of an apoprotein, opsin, covalently linked to 11-cis-retinal. This receptor is coupled to the activation of phospholipase C. Porphyropsin consists of opsin covalently linked to 11-cis 3,4-didehydroretinal.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MADNKSTLPGLPDINGTLNRSMTPNTGWEGPYDMSVHLHWTQFPPVTEEWHYIIGVYITIVGLLGIMGNTTVVYIFSNTKSLRSPSNLFVVNLAVSDLIFSAVNGFPLLTVSSFHQKWIFGSLFCQLYGFVGGVFGLMSINTLTAISIDRYVVITKPLQASQTMTRRKVHLMIVIVWVLSILLSIPPFFGWGAYIPEGFQTSCTFDYLTKTARTRTYIVVLYLFGFLIPLIIIGVCYVLIIRGVRRHDQKMLTITRSMKTEDARANNKRARSELRISKIAMTVTCLFIISWSPYAIIALIAQFGPAHWITPLVSELPMMLAKSSSMHNPVVYALSHPKFRKALYQRVPWLFCCCKPKEKADFRTSVCSKRSVTRTESVNSDVSSVISNLSDSTTTLGLTSEGATRANRETSFRRSVSIIKGDEDPCTHPDTFLLAYKEVEVGNLFDMTDDQNRRDSNLHSLYIPTRVQHRPTTQSLGTTPGGVYIVDNGQRVNGLTFNS
The following text describes a protein:
Function:
Probable serine protease inhibitor.
Subcellular Localization:
Secreted.
Sequence:
MQSLLLALLLLPVCSPGGASNLHEDLTLLRTDLALRLYRSVAAAGNQTNLVLSPAGAFIPLELLQFGARGNTGRQLAQALGYTVHDPKVREWLQTVYAVLPSTNPGAKLELACTLYVQTGTPLAPCFVEQVSRWANSSLELANFREPNSTAMLANGWGPRQTAGDEPVGSAWERGGGAESAQLVLVSTVSFQSAWRHQFSSDTQLLPFTCAQGLTLEVPMMYQMAEVNFGQFQDPAGHQVGVLELPYLGNVASLLLVLPRDRDTPLSHIEPHLTASLLHAWTASLKRARMEVFLPRFRIQNHFDLKNILYSWGVIDLFDPLRANLKGISGQDGFYVSEAIHKAKIEVSEEGTKASAATALLLLKRSRIPIFKADRPFIFFLREPNTAFVFSIGRVLNPLH
The following text describes a protein:
Function:
ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity. Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation. Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation. Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA; RNA helicase.
Subcellular Localization:
Nucleus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MDSADLPIPGFELRDPPVFASSTAEIKATMKLKETKSKPKSASRGTFQRKGIKVVGKWKQVTIDPNLFADGQMDDLVCFEELTDYRLVKNPSRLFSDETTKKRKAQAVSEEEEEEEGESSSPKKKIKLKKQRDAILVAEGSAAQDECEGKASEPGAQGEITVCSDQKVGGATSESLAQTVPRKKKNKGKKKLDTFQSTAPKVPKKAKTWMPEVQDQKADVSAWRDLFVPKAVLRALSFLGFSAPTPIQALTLAPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQWHKMKAPPIPSSAGVPPRLGAAAHRGSPCKDGAKSGVLPEEATIETEAQPSDSGVQATAKAGASAASAQAGLFCDDDAGEGPSSLVEEKQSKDREEKLDEEQAGKLKQELCDQIAVYKVHPRRPLLGLVLTPTRELAVQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELIKEKHPHLSNLRQLRCLVIDEADRMVEKDHFAELSQLLEMLNDSQYNPNRQTLVFSATLTLVHQAPARILHKKHVKKMDKTAKLDLLMQKIGMRGKPKVIDLTRNEGTVETLTETKIHCETDEKDLYLYYFLMQYPGRSLVFANSISCIKRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTARATSEGLSLMLIGPEDVINFKKIYKTLKKDEDIPLFPVQSKYMDMVKERIRLARQIEKAEYRNFQACLHNSWIEQAAAALEIELEEEMYKGGKADQQEERRRQKQMKILKQELRHLLSQPLFQENLKTRYPTQSGRPPQPVVAPRNVESALSCLSRQKRRRKKPKEHQAPPQPSSSTS
The following text describes a protein:
Function:
Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature egg by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the egg and early embryo (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, sarcoplasm. Nucleus, nuclear body. Nucleus, nucleolus. Nucleus speckle. Nucleus, Cajal body. Nucleus, gem. Note=Predominantly cytoplasmic.
Domain:
The C-terminal region is necessary for nucleus and cytoplasmic localization. The N-terminal region is necessary for nucleus and nuclear bodies localization.
Sequence:
MMKGAMGCPVAAVMEGSFSCTVANRFYQLLDDESDPFDNLREAERCWQQRKNLSKVVARRGDPGSRGCATRRELQKQRKQLGTPAPPPQPGQKQAPKQEECGGKDNSRAEKEHKTAWRPSFMEYLSSETESQAELTAQSLFRPTAKLNYERPRGCGRGRGGMQGRGRGGGINKSFDGFDQRGKREFGRQNDNDKIEMELTAPMEATAKTAKSPGVSEGELLNKVAEGKPREEVVQEMTLDEWKNLQQQNRPKHEFNIRRPESTVPSKAVVIHKSKYSDDIQKGELEDDYHIFRRAVNDITFQLDINFGSLPRPGCGSRGARGRGRGRQMEETGPQPEAMVQIVAPNPDDPEDFPALT
The following text describes a protein:
Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MEGEIALNSTLNATTTDIHLVTHNLWEVITIATVSAIVSIITIVGNILVMLSFKVNSQLKTVNNYYLLSLAAADLIIGVFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLVSLILWAPPILCWQYFVGKRTVPERQCQIQFFSEPVITFGTAIAAFYIPVSVMTILYCRIYKETEKRTKDLAELQGVNYLADSGVTKPQKTIIRSCFSCKLRSTSHEMNQASWSSCSRSTAAKSAASNSDEWSKVGQLTTFNSYASSEEDDRPVSPADFQTSLRNAECEDSKSGVGSVSEQLSFFQTPRRSTSQKSSKCVSYKFKPMAQEPHMEHHSNNRDSKMVSSVFSSAESMTVPSTSSASKPIDGTLKNQITKRKRLVLIKERKAAQTLSAILLAFILTWTPYNIMVLISTFCSDCIPLSLWHLGYWLCYVNSTVNPMCYALCNKTFQKTFRMLLLCQWKKKRLQEKLYWYGQNPVVSSKMS
The following text describes a protein:
Function:
N-acetylglutamate synthase involved in arginine biosynthesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MNLMTPGLPLPYTMSMMVSRRVPTRRLLNPPLNPNIRSYYLRSSEDDLSSNLKPSADKLQRELILSVLEAHPSARDSRLYLKSFAPTSKKIPKNSPDSSSNSSSNDTFNPGFPTGEAMPTTATLAATTSSSTFVQPNKSNETSIRQTNKNQNRDVAQLILSTPNQHTGLVKIQGPFTDRQLQSIVDGVIYLKTLGLMSIIVLDDEAWHYPSHTSLTASLPHKSKPPGILHTINSSESRRQAIVRETGRLSAMLESRGGQSRPIQEGVLRLTDDRNQDGDGLDLYIDNLDVLKSAIKNQEIPIIPPIAINSSCATICVSADEVVKSLAKGLAAVGKSPNSLNHTIDAVSAYHGQPATVRSPTHQPFDQKNKDRLEEDDNEDNELDLTPLRLMIINREGGIPSPARNGHPHLSINLASEYEFINETFRWGDSHPTSLANLSMAKSCLKYLPNESSAIIVSHRSPKSLIANLITNKPAHSPSLKHSILLNHARDIGLATPTLIRKGLPIKVIRGIDNLDLTKLKDLLEKSFKKTLDHQRYFERLKNSLRFVILAGDYQAAAIVTNEWEEKQESREGSESEDREPIVYLDKFAVLPSLQGEGIVDFLWGALRDESFGLGNLDALNNNGGLSGLGEPVDLVWRSRTDNPVNRWYFERSNGFIKLPPSNPHRLPSTSTSSTKPDFSLFWCTADLPSSIDIKHQHSSSTTATNPSVDPSSSPLIGIIRPTKLQTWCRVINQIPSCWAS
The following text describes a protein:
Function:
Alpha-glucosidase I and II have high activity towards malto-oligosaccharides and starch, while form III and IV have high activity towards malto-oligosaccharides but low activity toward starch.
Sequence:
MKKKIPSLALGILLVFLLQYLVAGISTSENDPEGVIGYGYKVKSVKVDSGTRRSLTALPQLVKNSSVYGPDIQLLSITASLESNDRLRVRITDAKHRRWEIPDNILHRHQPPPPPPHSLSSLYRTLLSSPTTNRRKILLSHPNSDLTFSLINTTPFGFTISRKSTHDVLFDATPDPTNPNTFLIFIDQYLHLTSSLPGTRAHIYGLGEHSKPTFQLAHNQTLTMRAADIPSSNPDVNLYGSHPFYMDVRSSPVAGSTHGVLLLNSNGMDVEYTGNRITYKVIGGIIDLYFFAGPSPGQVVEQFTRVIGRPAPMPYWAFGFQQCRYGYHDVYELQSVVAGYAKAKIPLEVMWTDIDYMDAYKDFTLDPVNFPLDKMKKFVNNLHKNGQKYVVILDPGISTNKTYETYIRGMKHDVFLKRNGKPYLGSVWPGPVYFPDFLKPSALTFWTDEIKRFLNLLPVDGLWIDMNEISNFISSPPIPGSTLDNPPYKINNSGVMLPIINKTIPPTAMHYGDIPEYNVHNLFGYLEARVTRAALIKLTEKRPFVLSRSTFSGSGKYTAHWTGDNAATWNDLVYSIPSMLDFGLFGIPMVGADICGFLGNTTEELCRRWIQLGAFYPFSRDHSSLGTTYQELYRWESVAASARKVLGLRYTLLPYFYTLMYEAQLNGIPIARPLFFSFPDDIKTYGISSQFLLGKGVMVSPVLKPGVVSVTAYFPRGNWFDLFDYTRSVTASTGRYVTLSAPPDHINVHIQEGNILAMQGKAMTTQAARKTPFHLLVVMSDCGASFGELFLDDGVEVTMGVNRGKWTFVKFIAASAKQTCIITSDVVSGEFAVSQKWVIDKVTILGLRKGTKINGYTVRTGAVTRKGDKSKLKSTPDRKGEFIVAEISGLNLLLGREFKLVLH