lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Although the function of this ferredoxin is unknown it is probable that it has a role as a cellular electron transfer protein. Involved in the in vivo assembly of the Fe-S clusters in a wide variety of iron-sulfur proteins.
Sequence:
MRQDEWINRFVAHWLATPLTRFEEITNMPKIIVLPHETLCPEGAVLEAQTGETILDVALKNGIAIEHACEKSCACTTCHCIVREGFDSLEESDELEDDMLDKAWGLEPESRLSCQARVADEDLVVEIPKYTLNHASEDH
The following text describes a protein:
Function:
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Has an essential role in mediating growth by negatively regulating insulin signaling. It also has a role in maintaining presynaptic function in the neuromuscular junction synapses of third-instar larvae.
Subcellular Localization:
Nucleus.
Sequence:
MENNEVEHTDDEDSSASYHDLSDHEEDESTDLSGDELEINNPEDIQIGLPEQYNPQDQDLVGDHLYLGAMEEVRGRILLDEDSIIEMPVVVQEGLICVPGQTLPLTISHPHIMAMMRRVIEGNHIFGILSFRPFEPHINNAKYKIGATAEIYEYGEEVEGLESGFGFRIKARIRQRIKVIQARRQIDGITIARVQILPELEVSDSLYQCRSYSLDKHRLSTATSSDISVASLLSKKRIYDKQYKIPFSVWPSWIHRSYDLQFIAQRVMLELSTSIFVGSSAFADVGSGSIVPRNPVDLSYWVIQNLPLDDELRLELLSINNPNQRLRAELSILQRCESLCCRECDYAIARQTDVFAMSKIGPQGVYVNPFGHVHETITVHRVDGLSVTTPPSTEFSWFPGYAWSIVNCSYCRSHIGWLFTANDRHLQPASFWGLSRQSLKPRLKVNDESEFIAVM
The following text describes a protein:
Function:
Phospholipid scramblase that transports phosphatidylserine (PS) and phosphatidylethalonamine (PE) bidirectionally from one leaflet to the other of the phospholipid bilayer to at least partially collapse the membrane asymmetry established by NEO1 and other flippases. The PS scramblase activity has been disputed. Functions in the trafficking pathway from endosomes to the trans-Golgi network (TGN).
Miscellaneous:
MISCELLANEOUS: Present with 937 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein.
Sequence:
MSTTGPLDATLIRDVAVATATKASYDMSDTLYSYLPKVDQFYIPEWLTMQFIANNLISFTPLFSYGTTIISIEKCKTALGFSIDICATMLIASILRISYYLITPYEITLLRQSLVMIFIQLILLRTSLKYRPDEYKYQNLTDVESLSHLIHDIWFEFFSCINRPKFLSEDWKNLIKSLSFTNLLKFSFKIFLAFFYKILKFFDPNFKRIGAFWQWDDDKNFWRFLALFATVQILVTFFISNILNWDSLAQGLGSIIGSLGLLVESLLPLPQIAILYKLKSVQGFKLILLVSWLCGDTLKITYLIFGAKNISALFVIFALFQMSLDFYIGGQYIYYRYYYPKLRHQHHPNDSNSPSDEDESEMYELDLFNTLQKDVEKALKQDSNDTSDSPQDDQVGKSQAQAVTL
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form H4K20me3. H4 'Lys-20' methylation is apparently not involved in the regulation of gene expression or heterochromatin function but participates in DNA damage response by giving a 'histone mark' required for the recruitment of the checkpoint protein Crb2 to sites of DNA damage.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MRQTNTHLETFSLFDDVCTCLLVDKVFYWSQIHKVRKLVDRSIERMESCSIINIITKYIIEQTDLDQAAKNILQFRELDPLLRRLSSTSLLAFTRHLKYYLSLYLPSCKFEICSTNQYFSSSKPEACVIARESINAGEDITDLCGTIIKLSPKEERNIGIGKDFSILHSSRLDSMCLFLGPARFVNHDCNANCRFNTSGKRIWLRCVRDIKPGEEITTFYSSNYFGLENCECLCVSCERMGINGFKKLFHTSATSTSCSSKSSSDVSDLSSLPQSNRYVISEEDRSFLNIWDSGGELSDASSSDLDEEFSLFIPRHKKRVWSREKRLLSEMAITNHSPLLNVDDYRKFREDLWKKRHGKRKVYQCSNCSQTFINEDIQNSSAFCPKCIRHSKLFSLPWPCRHKVNRELKLEKEKEINTKRNLVTSSHSMSLRHKKAVDYQS
The following text describes a protein:
Function:
Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
Sequence:
MTEANAAPVTGHSPNALAAVEAEIARACKDARRDRASVTLIAVSKTFDADAITPVIAAGQRVFGENRVQEAKGKWPALTSVYPDIALHLIGPLQSNKAKEAVALFDAIHSVDRPSICQALAKEIESQKKHPQLFVQINTGEEPQKAGVAPGEADAFLASCRDTYGLTISGLMCIPPVDEPPAAHFALTAKIAARNGLTNLSMGMSADFATAIMLGATHVRVGSAIFGHR
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNKILSTFYENYRNTPRNIKFVDIYILITLVNILLLYMYGYFSCSFDEKISVAAIFTALGNLTFSIALREQISNKSLFNIKREKIIFDFVLCSLVLYIGVFSYMHLN
The following text describes a protein:
Function:
Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus. Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system. May also act through the regulation of growth factors activity and downstream signaling. Also regulates extracellular matrix assembly and cell adhesiveness. Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms.
Subcellular Localization:
Secreted.
Sequence:
MVLLHWCLLWLLFPLSSRTQKLPTRDEELFQMQIRDKAFFHDSSVIPDGAEISSYLFRDTPKRYFFVVEEDNTPLSVTVTPCDAPLEWKLSLQELPEDRSGEGSGDLEPLEQQKQQIINEEGTELFSYKGNDVEYFISSSSPSGLYQLDLLSTEKDTHFKVYATTTPESDQPYPELPYDPRVDVTSLGRTTVTLAWKPSPTASLLKQPTQYCVVINKEHNFKSLCAVEAKLSADDAFMMAPKPGLDFSPFDFAHFGFPSDNSGEERSFQAKPSPKLGRHVYSRPKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFVVNINSNMSTAYVGTFARTKEEAKQKTVELKDGKITDVFVKRKGAKFLRFAPVSSHQKVTFFIHSCLDAVQIQVRRDGKLLLSQNVEGIQQFQLRGKPKAKYLVRLKGNKKGASMLKILATTRPTKQSFPSLPEDTRIKAFDKLRTCSSATVAWLGTQERNKFCIYKKEVDDNYNEDQKKREQNQCLGPDIRKKSEKVLCKYFHSQNLQKAVTTETIKGLQPGKSYLLDVYVIGHGGHSVKYQSKVVKTRKFC
The following text describes a protein:
Function:
General activator of RNA polymerase III transcription. Interacts with TBP. Binds to Pol III subunit C34 and to the TAU135 component of TFIIIC.
Subcellular Localization:
Nucleus.
Sequence:
MSKPRKQQKCKTCGHTQFDVNRYTAAGDVSCLRCGTVLEENPIVSEVQFGESSSGAAMVQGAMVGADQARATFAGGRQNAMESREQTLSNGKRKIKRIAAALKIPDYIAEAAGEWFRLALTLNFVQGRRSNNVLATCLYVACRKERTHHMLIDFSSRLQISVYSLGATFLKMVKALHITSLPLADPSLFIQHFVEKLDFKDKATKVAKDAVKLAHRMAADWIHEGRRPAGIAGACVLLAARMNNFRRSHAEIVAVSHVGEETLQRRLNEFKKTKAGTLSVKSFREVENLESSNPPSFEKNRAMELKISKKLQQQQTDNFEDLSKMTEEEKQSVFGKLSKEEAQKQLLMNTILSDITITTENLNDQMDRILKMKKSSLENSLYKTPYELALANGSEQDPSKIWNINKPKNLVANLPKTDDILQNVSSEVELNSDDDDEIVLESKLTEEEVAIKERIWTGLNHDYLVEQEKKRLKQEADELTGNTSKSSSGNRRKRNKSSLPAELRKELGDIDLDEDGTPRSAADSAKMYISKTSVSKKINYDSLKGLLGGNMGF
The following text describes a protein:
Function:
Required for transcription elongation. May also be involved in pre-mRNA splicing (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKKEHHSPWPDSLKEFIGRCIQDAEENSQPELEDEVKLLISRQYEMGNIWNVDWSSMNLESLRKLTNAQNTIIEDKKRKVEKPVSGNQFSLLSEEDEVDKKEKRRRRFENGSRSQNNAKSEELKVNPENGAIIGRSTELEKRYLRLTSAPDPDTVRPLPVLKQTLELLKKKWKEEKNYAYICDQFKSLRQDLTVQRIQNEFSVLVYEIHARIALEKGDVGEYNQCQTQLFHLYSFGIPGNTKEFLAYRILYMLFTKNRSEMNSLLANLKEEDKTNAAVTHALEVRSAMATGDYYKFFHLYLVAPNMGGYLMDLFIERERVQAMIMMCKAYRPSLTMEFLANTLAFEEMEDCVNFFRSCNAVYDSKDPNRILMKESTDRFEKCMKKHAVVDIKGQI
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSAANERAALQGAQPMVDLQKLLADVYDNALTDFVQLSTEQGLGDSDRKHRLLLHLHGTRQQLLRSLALVNWKPMKVLAELADHDRVLDLAAGHVRACTELVNALRQQAAGRIMAGAYLNAFDVNTALEVLTTGTYQELPSIILHRPPLFQPPPAPLSRQRSRLAHVTHLIRARLVQVAMPPGLKVVSVGNGTAVLRAEGLYEAKLTLVPSEPLPGLDDAAAAAAGAGAAGAEGGGEEQADAAAGEAGPGAGGLPGWAAEAVAAASGDAAAAAAAAQRWKWRLIHFVLLIGVPFYDPRQPGQILNTCNFHMVLAADNAAYLRWQRKGPGAGAGAAAARSAVSESVATPAPSGLPGAAAAAAAGAGGGGGVSLAAAVKKAEDDEVGAPLAVMHAILTDVAGRLLADELAAAARALAAPGSRWHGHIAVKPSQLLHPGVRIEYWVQAPPLMGKSALPRVGPGEDLRGVRPGPPYLELGMGDSGCVEVQHGPSVLHKPVSMSKLRLDTFRVNVEEVLMRSANMSAQLQLLQIRRELKENLFAAMGLRAPTMRLTSLARQLWCRDGVPLVQPGTEEDGAAAAAAVTGGAAAAAAVGANASAMDIDGGAGVGAGPSGTPGPAAAPAAAAAAAIGAIPPPSSPPPEVTGLLAAAAPPEETAGALVLLNAPVLEYLVTGTTELKIGKHLFSGRLTLRPGQDERDEGSLHHAAEVAASEDSVNAAALSAYNSAPDDSYPASRALKEACAALCRVLQRTHNSTDATHFIQAARRASLHISRLPGGMLEAFTAANPGLAIEARPNEKAATWALQSVPFPPNFPPLELSGAADTPPLRTPQCLAFFLQSRLSLHSPHVLVAVSCNRQLMPIKVLSCIPVPPSTYRLPDHVVAAYMAVSVGAGGGGGGGAHSHSGGAAAGHHHPHHHGGQGGQAALAHSPPHSGGSSPRVLANGGEASHGHSLQHPQHSHSQHHHHHHHHLGGPSPDTSPVRESAPSALGPASSSHGPLFRPSGGGTASITAAGTQLSDAPAGAASGQPSLPGTASPASAAAAGGAGSGPLARRGGGGGGGGGGAVSGSGAGGRPTGQQVAVMLAQQQLSSVVRWCRRRMVWEVLLVQLAAVGAAFEELCSPDAPCQRVRVTRVAGTALPCPIARRPGLAPARVGPACLELELGPDALAGQVTARLWGRFLCSPVCEPVVANRAVGGAGAGGSIGAAAAVAATHGFVLSDEDAPGTVPYAGRGDGGAAGGGGGGRGAPLLCLRRQYCLERGDSALTIVQEVAAVIRMQTLLARLEMTARPAAAATAGTGAGPVLPQRLSVLTRPTAAAAEAVPQPGPRPLQPHNSQEEGVSLAPPAKRLKSEPRVLGDGCDVPMSNGTQPNGGALTAVVDAQAPAQAPAAGAAATTSAATTGTATRGGCGLRWHWPLVGTLTLEHYSCSAAAIRYTPAAGAAGAPGGGGAGEAPAADAATSAIMPPAPLVLHITWAPRDVRGIHGGGGGAAAAAAAPPQTPGAQGGGAAAALFGPLASASVPAGVPAPLANTPSSSTAPHAHQYHHAAHAHHAAAHLHGRGSPLLPPEAVATSSRPVQARAGEPFGTAFCDLVLCTVTCSSGHSLPSEYLHVLEEFAEAGEEGKLLDAVAVAAWPLAGFFTALRPAVLARHGLVLDSDVRPALSQPPYCHRIVCRRRAPNTGHVLMDLLCQAVGRSYIKVSITAVGGAAAAAAAAAAAAAAAGTGEAGLERSSTSGSATPNKQPEPGAAATAGEAGGASQHVLQALKAQAVTRLGPRGVSVSVGGRGAVYTGFGHKPSGVPGPGAPLWLLVPNDCVQAAVELVYSVLN
The following text describes a protein:
Function:
Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2. Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity).
Miscellaneous:
MISCELLANEOUS: NOTCH2NLA, NOTCH2NLB and NOTCH2NLC paralogs arose between 4 and 3 million years ago, after the separation of hominids from the chimpanzee and during the early stages of the expansion of the human cortex.
Subcellular Localization:
Secreted.
Sequence:
MWICPGGGGGGGGGGGGGDREDARPAPLCCGRCWRSGCAARPPRMCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPETVRRGTELWERDREVWNGKEHDEN
The following text describes a protein:
Function:
May be involved in the mitochondrial lipid metabolism.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRRSLSVVFGRRTIACKSCGIELQNKIKDGPGYFVTPQKAIRPAAKQLELAKQLLYGERLRIEKQLTGPDRNTLEKWKELVPPSCKRCMDALHHNRYDTAEFPEHTLEDVGKGVPRDAVVYHIAPLWQFPMGLDRRVLQSSKKVCVLFSKIDMVVQRPSHMPQDVGAFFQSLLYHDLHVKITNFRFFSALKQWNIQTVRNALSKESYLLGGPNAGKSSLINALMRTVVYESRRLVSSKQSSATPADLPPKAHLDIHSAGVSTIPNFTRQPQQYDIKGKIIHDVPGYRTSKSHTFDFNSMIQKDYLLRLRKSDSKTYLTKKYTSINGTESGRCYTVGGLFYYVPPAQTINQVTRYMPGDPQKFQSIDKGLEVVRDVYSDRWDKETGSHPLAEYIHVNPALGDKNSFVRHVIPPFQGTIEIVMRDVGYLRVVATGSFKFLGLHEIWVPKGIEVSVREPLTDVFRTTIEAYRDSGSVANVAQMIIKRPYISSTYPMAHNETDPLAKMREMYLERTASNLSARRLMNRDPLELISQKQKERVNLYWHYCW
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MASVVSSSAANAQGQNARQSARQTRTNPSRTSKTLGRSSFAYGHSSMIEAPPTPPAPHGFYPALTHFTDAITALPREFRRHNSLLKEVDAKAWALEDNLLQLLKVSSESQPLPCPPNPAPIVDGVVRDDIVSVNPSQPPESQESKNRRLLFDRVRRTLVDLMMTADEKNHVISNANDELDRQLLRIDGIFPFIAGEISEEARLGSLTHWAYSNRNATKTATNERPRREVASNKQDLNHALENEAGSRSDARRDAARKQRRTHADSDFDDARASGSRKGQASKPRSGAGAATGDLSAVGHGAQTSGASGASGATKRRKVERPPAADAGAAMERSASGAGNASGRGASKDTTASDATKKRSRAPNTNAAARKRNNTGTSAANSPVLAPTPLAGASGAVRSAASPGPGAAARPQSSRAQQSSGQPTNGRQRPSSSASNRLTSNSKVVDTKTLPKETPKADMVAAALNSELQRQAEEENSGTATAKAVGPVSMKREDTETRPAESVESRETPVPQASNAAPKGRSSKTSTPVLSTLSEPNSQRTRPTRNTDSAPAKRSHKKSGSVAVSQQRAVSEEEDSLHEGDDEDEDGEPRYCYCNEISFGEMVACDNDACPREWFHLSCVGLTKPPGKNVKWYCNECKENMRRNRNAR
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATP synthases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of 10 OLI1/ATP9 subunits is part of the complex rotary element.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein. Note=The F-type ATP synthase complex is anchored in the mitochondrial inner membrane via the F(0) domain with the F(1) domain and the peripheral stalk extending into the mitochondrial matrix.
Sequence:
MQLVLAGKYIGAGLASIGLVGAGIGIAIVFAALINGVSRNPALKGQLFTYSILGFALSEATGLFALMIAFLLLYAV
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular Localization:
Cytoplasm.
Sequence:
MVRYAATEIAPAKSARSRGSYLRVSFKNTRETAQAINGWKLQRAQKFLENVLEKKEAVPMRRYAGGTGRAAQGKQFGVSRARWPAKSAEFLLGLLKNAEANADAKGLDTGNLVVKHIQVNQAPKQRRRTYRAHGRINPYMSNPCHIELILTEADEVVQKSEAVVREEAHLSSRQRGARVRRAITAA
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus.
Sequence:
MDGLEFVISENKEDLLHSSSPNQYVVEQTYSKHELPGKLRDAYVSFSRQGTVYILTHFDTLFSALVKFDELALSQQNDAWKVVSQSIPQLISDVNKHLNSDDNNPETCKELVTITKMIVYLLCLFLQNYETRSLVVPGSDAKSGRKKKKPVDDGFDLEAERNFAITSLDHLIQLPIHKLWSPPVVEQEFVNLVSNACYKILENPSISHVRLKGTVESVFRVIGALVKRYNHGLGFQLKIIQLLQHFEHVAPACVHGLVTMIELFGCSQMVVELVREIGKVDPHDLARDTSSSRNYAAFLSELAERVPSAFIPCISLLSVHLEEESFTMRNSALSIFAEIVMQELSGEDLDERKRELRDQLLDPLLEHLHDVHSFVRSKTLQLWHKLSLKHAIPLNLQHKVLTMTTGRLNDKTGTVRKNAVQLLIVLMQGNPYGERLPLEELGAKKESEEAKLKEMLEVSGNQPQRIQVDPSKCGPTKTELWNAMEPEILVAIHEVFDEEDIDMSMSELTNEEVIQQLNACNYKRVARMFITEDDEEQEDPQPPQEEESKEIGQQRMLVMFLKDSHAFASSVYAAIPMVCQLLCSKQTSDILEAIDFFVTAFEFDVLDAMQGVRRMLSLIWSSEEDVKKAVVNAYKRLYMNMEATGSKRRALQVVSNLSALISLSTQGELASLEELIAMCVKSGDLPKICIQVMWEKFSMALPDTTEEESRSALMLLTMVASAEVQVVTSNVNVLVSVGLGERGSKDFRLAHLTCAALLKMAPTKAATDCKEQPMRFPPTNEIFECSKKLLVEGLTRLEDVHYSQFATTSVSLIYTLAEHPDMIMGDVLKEMCAIVYKSSRDQSGNLMENAELEVPTTVLTRIFVVAGQVALRQLIHLDVHVYSELRRRARVREEKQEETSKQKRNLLQSASRRRVSTRPQQEQCESGEDDELVGAVADDDEAEYVRKICESEIVTGGHSLLSSMAPLVILVNSNPAKYPDPSLRAAASLCLAEFMLVSPQFCSQHLRLLFTVLEKSPEEVIRSNLVIAMGDLNFRFPNLIEPWTPNLYSRLRDDSPIVKRTTLNVLSHLILNDMVKVKGQISDIALCVIDPDTRISSMSRMFFSEFARKGNALYNVMPDIISRLCDPEAAVAEENFRVVLKGIIVLIQKDKQNESLVEKIILRLGASRTERQSRDLMYCLSLLSFNERSLRRILEHWNCISDKIHEEGVVETLNAILTTTKKAFAKQEIRGLIDEIEAKIQETVDADQDEQQVVRKAQATQVTKAQAPKNKPKRKQRAKDLDSEEEVSMDDDEPEMPGHPAHLGTPHSPNKKSPLRHGRNIRKKIAIPQVSSDDESSVEEEKDDDDDSEKEDRKAQLAAKSKKNMGSTRSIRATRRQTEADSGSDQDVFIKPASRGKLNPGKNKLPEKKKSTTTRSRR
The following text describes a protein:
Function:
Hydrolase that deubiquitinates target proteins.
Subcellular Localization:
Nucleus.
Sequence:
MEIETDQSIEAMDTQDTQEVEILTSDLQQTQQQRNSPPQLPKFKNLIQPQLHAVGAVTQLPSENGNMPPQQLLADSSSTSFGDGEAMGIDDESKEDQFRSETTFSFTVENVVQLKSQRLSPPVYVRMLPWRIMVIPNDRALGFFLQCNGENDSPTWSCNAIAELRLKCHKPDAQPFTRARIKHLFYSKENDYGYSNFITWQELKDSEKSYVHNNSITLEVHVVADAPHGVLWDSKKHTGYVGLKNQGATCYMNSLLQTLYFTNSLRLSVYRIPTEADDSSKSVGLSLQRVFHELQFGDRPVGTKKLTKSFGWETLDSFMQHDVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKKNIYESFQDYVAPETLEGDNKYDAGVHGLQEASKGVIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYLAESENTLADYVLHAVLVHSGDNHGGHYVVFINPKADGRWFKFDDDVVSSCRKQEAIEQNYGGMDDEISFHAKCSNAYMLVYIRQSELDRVLGDITESEISSDLVERLDLEKRIEMARRKERGEANTYVSVHVILEENFEEQHKRRLFDLEKVHPRVFRIKQNQTVDELVDLFVRGFGVSRQRMRMWNLCTAQTQKFSHFDFVAEGSRTIEQISTSQKPWVIWLQLAWTDVPGPLPPFNPKTESLLFLKYYDPRNKRLNYIGCTQQPHTRRLIDLVPDVNSKLGFEPDTELTIYDEYADKKLVNLNEPIESALFIPQDHLQGHILIFERENVDAKLDLPTVGDYFLDLVYRIEIIFSDKCNPNEPDFTLELSNRYNYDQLANAVAERLNTDPQKLQFFMCINNYKETAGNAVPYTFKGTIKDLVSYTKQSSTKRIFYQRLSLSIHELDNKKQFKCVWVSSDLKDEKELVLYPNKNDTVKGLLEEAAKKISFAENSRRKLRLLKISNHKIVAVCKDDIPLDTLLKSNESITTAQGAQKTFRIEEVPAEDMQLAENEFLIPVAHFSKELYNSFGIPFLTKARQGEPYGALKQRIQRRLNVQDKEWENYKFCVISMGHNADVNDNTPVDLEVYRSWTSGQLPFFGLDHINKSRKRSSLNFSEKAIKIYN
The following text describes a protein:
Function:
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
Subcellular Localization:
Nucleus.
Sequence:
MALHCPPTALATSSTSLFIAAGPALHVFNPSTSTFASCAADGTGGLIRLLAVREDGEVAATLGEDKQLAVWDIQHDRPQFRHTRTVVKKGSCLSFAKDGSIILTDKVGDVYSYPLDPVPIDPSAERPPMYTLVADPSQNPDATYLLGHVSMLNAHVMTPDGRRIITADRDEHIRVSRYPKAYVIDKYLFGHDGFVSALHIPPSNPSLLLSAGGDPSLLIWNPSTGKLLTSVPVWPAVLSHRRVRSHLRRHKPGSRKLKMDPVPEDMDEENQTFYTAPEGYMLPSGQGVCIKKIESVKIGGETVVLFFSEGASAIHSFILPTDPEGVKPTVHTLPLPHPLIDFTPIPSTSSADEKEVLLSLDTAWDVLKKNPGPGIEGRQDTIQRDDLSDEEKRNISKIFSVARISADGHLSLGDASVYDSLVSNLPSTDIKTLSNVNLYPLLCVLPRWPGFEEGDEELTVNTGTPDTPGTPGPADAVSLAPTSGAFLQKSYTQEELEKMNTKQLGRLKSAGIDVGSILLARQKKAKEEHKARKAAAKAKAEAQKNQKEGGRPAKKKKKVEMSEEELANA
The following text describes a protein:
Function:
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MFIILLVQCINAQVNPMLYKWGTYKPQLIHAITERNMQTFNPLTITFYYFMNNNIRWEKSIKYKINERSNDEPTYYQYLYHDGERYAIHETIDGEYKVRFTNEFYKVNPEKIEDWVTTVVNNDALVGDEEYISLVYSIAIEKLNQEKTDLRKLQVEEEGDSLKITITTAQQVNYIYVALESNGKQVNLNQNDNFGYSLQFQNPTLNYNLRTLLYSELRKTKEDIPFKFNKTIDQEQGNIVFVQYVAKRNELFKFQLRYMQREISVSSDYFFDARILKKLDNMNFFSQFNRTFNKIPLKNPFYLSCSISSFANLIGGFATSFGNIECEEANPICSQQKMMFTPTPSRFGFPRPFLWDDGFHNMIVCRWKSQLCIQSLLDWFDTMSSNGWIPREQARSPEQKTAVPQAFLAQKQSETNPPTFIFNFLYLDSLKNGEIQQQVRKLYTKAIDWYHFWIKSQGVNEGDNFLLFKWWGMNDNINFGSGMDDWPRSHNGLKSKFNIDASMWGWFFADSMQKLAAIYDPQKSNQFHQTAEMIKKSINKYHLDPDDKIFKDVLIDGSFSPHLGYPNLFPIAFGFIDPTKSDILDAYVNMIKKELWTNHGLRSLSINDNHFGKGDNYWTGPVWIPINYLVLRGIQKYYSTHKGLMDLYKELRENLMNTVCINWRDRGQHYSTYTRYFFEHYNQRQDGLGRGYHPFNGWTSTITLIIHEIYD
The following text describes a protein:
Function:
Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factors 3/IRF3 and 7/IRF7, transcription factors critical for the induction of interferons alpha and beta. This blockage is produced through the inhibition of host TBK1, by binding host TBK1 adapter proteins TBKBP1 and AZI2, thereby producing a strong inhibition of the phosphorylation and activation of IRF3 and IRF7. Also acts as an inhibitor of the cellular response to type I IFN by interacting with host STAT2. Mechanistically, exerts its inhibitory effect after host ISGF3 complex (composed of STAT1, STAT2 and IRF9) binding to the interferon stimulated response element (ISRE).
Sequence:
MNAYNKADSFSLESDSIKDVIHDYICWLSMTDEMRPSIGNVFKAMETFKIDAVRYYDGNIYELAKDINAMSFDGFIRSLQTIASKKDKLTVYGTMGLLSIVVDINKGCDISNIKFAAGIIILMEYIFDDTDMSHLKVALYRRIQRRDDVDR
The following text describes a protein:
Function:
Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDIVEIKSKIKEWEYAFRKQHNKLPSKADIKDDVEIHKLYSLYKSIKSGQQQKPSKQETVNEPASVQSSPVKRNDYSPRGELGPTPQANGRVLSIFDLKMTPPDSSPLKHKSDKASPSAFAMPPPQSPVKNIIETPTKSKNKSFVTPIKGRKIVFETPSYLNKHRQNPQTPDSHNNNNNNNNNTVINFSVSPSPFKTQRSIGKRLTEVYNTSLKEAEDLKSFNLEEEFQSHEEQESEETETTTNNDRKIAPRSKRTQKRSTRRVKMAPRPVNSKPSLENVNLQDHITKLEEGERKQLVAYMDSDEDDENRDGEVGIASVFESPTKKTRMPVSNNFKRLKINDPRSRRFKQRMRR
The following text describes a protein:
Function:
Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria. Mitochondrial NAD(+) is required for glycolysis and mitochondrial respiration. Compared to SLC25A52, SLC25A51-mediated transport is essential for the import of NAD(+) in mitochondria. The transport mechanism, uniport or antiport, its electrogenicity and substrate selectivity, remain to be elucidated.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MMDSEAHEKRPPMLTSSNQDLSPHIAGVGDMKHYLCGYCAAFNNVAITYPVQKILFRQQLYGIKTRDAVLQLRKDGFRNLYRGILPPLMQKTTTLALMFGLYEDLSRLLHKHVSSAPEFATRSVAALLAGTTEAILTPFERVQTLLQDHKHHDKFTNTYQAFRALRCHGIAEYYRGMVPILFRNGFGNVLFFGLRGPIKESLPTATTYSAHLVNDFICGGVLGAVLGFLSFPINVVKARIQSQIGGPFLSLPMVFKTIWIERDRKLINLFRGAHLNYHRSLISWGIINATYEFLLKIV
The following text describes a protein:
Function:
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.
Sequence:
MAALVGQPLRSPVLMMMMMVVLLGAGMARGETLYGPGDSVSILNKESVARAVFNSSSAWLLEFYSSWCGHCINYAPTWKSLARDVSDWEPAIKIGVLDCAEEDNYGTCKDFGVPLYPTFRFFTAFTKEFTQGENYKAGGDRDIQTVRQAIIDFLQTSPAESKPQAYSSLEPISSSEISSLLTQKQSHYTAIIFESEESYEGREVILDLIQYSNIVVRRALPSDKAILEKLGIGSVPSCYLIQPNGSHGLINDVKSVRSQLSSHLKALRGVRKRLPSETAHSGLSKGSQQEDAAMKEFDRSKLYMADLESGLHYILRAELANHHTLEGEKLKTFKDFVTILYKLFPGRPRVMKLLETLQEWLVSMPLDKIPYDAILDLVNNKMRISGIFLTNHTQWVGCRGSKSHLRGYPCSLWKLFHSLTVQAAVKPDALANTAFEADPQAVLQTMRHYIREFFGCRECAKHFEAMTKETVDSVKTLDQAVLWLWRKHNVVNNRLSGAPSEDPKFPKVQWPTSDLCPACHGQMGGMHSWNEDEVLAFLKRYYGNQEISLEFADPRKDLSEAADGNKEPHFNKKPQEDVNKRNPQFLDKLVPKKPEKSLNSKNHQSVSFLGIGFSNIDMSLCVILYLTSSLFLMVMYFFFRFRSKRWKVRYNRPFV