lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. A protease cascade involving ndl, gd, snk and ea results in activation of the spz Toll receptor ligand; acts downstream of ndl and gd. Activation of ea requires both activation of the ndl-gd-snk protease cascade and sulfation of a vitelline membrane component by pip. Localized activation of the Toll receptor in the ventral region of the embryo defines cell identities along the dorsal-ventral continuum (Probable).
Subcellular Localization:
Secreted.
Domain:
The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.
Sequence:
MIILWSLIVHLQLTCLHLILQTPNLEALDALEIINYQTTKYTIPEVWKEQPVATIGEDVDDQDTEDEESYLKFGDDAEVRTSVSEGLHEGAFCRRSFDGRSGYCILAYQCLHVIREYRVHGTRIDICTHRNNVPVICCPLADKHVLAQRISATKCQEYNAAARRLHLTDTGRTFSGKQCVPSVPLIVGGTPTRHGLFPHMAALGWTQGSGSKDQDIKWGCGGALVSELYVLTAAHCATSGSKPPDMVRLGARQLNETSATQQDIKILIIVLHPKYRSSAYYHDIALLKLTRRVKFSEQVRPACLWQLPELQIPTVVAAGWGRTEFLGAKSNALRQVDLDVVPQMTCKQIYRKERRLPRGIIEGQFCAGYLPGGRDTCQGDSGGPIHALLPEYNCVAFVVGITSFGKFCAAPNAPGVYTRLYSYLDWIEKIAFKQH
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MATQTRTTTKTTTSTKGFAQYEQCADAAQKKAEDDRSRREAVANSGNLVLLYFLREVQRDVEGREGATNWLHGLRNAVRSVQDAPLRIRTRDQLKALRGVGDFTARMVDQALWKKYPPGEPDSDEEQIEREYQRNQETAGAAAAGGAGSGRGGGRGGGRGRGRKGVAAALETGIGPHDIPFGDTLLVNTAPLGGDDDAAGGGRGRGRGRGRGRGRGRAAAAAGCGRGRGGARKRARGGPDGDDDDDGSADDAGPSGRGGFGGDNLFGGLAGGLAGGLGGLGGLGGLGAGGMGGAAGGGAYGGGGGAYGGGGAYGGGGGAYGDDDDGGGAYGGGSGAYGGGAHGGGTQAAAAAAAAAAPPPRKKARRASGADDGEGGGGRGKKDYVPRPGTANYAFLVLMYMAKKRDGTTHWTKEDLMAAAQASGLAEKDIRGTKDLSAPGGGANPANFYDGFSCFRGMISKDPQLVLERTKTKGVRGKDYSLTNAGWALAARVYKSAVRYREVQPLPGLTEAAVHSDITTYCSLEGLPLLLEAYPAGTPKSNRGRAYTGFVPPPRSDNGGGGAGCGGDDPASPAAAAAAGAAGAAGPSGRGAAGASGGGASGRRRKPSTARAGSGGSGGGGLGSQGQGTAGGGYGGYGGYDDGDIVDVDDGIEDLVGSQNMWGGSQLQRQQGAGASQQQWSQHAAGASQRHATGAAAAAATTGAGGTGAGAGGWPSADYGSGGSQAHGHSTHDMAGAGPGAQPPRRLSAAAEAAARAAEARAAAAAPRPAPPPMMPAAAATVAAAAVAAPAPPPPQRARHQEPEVVDLLDSSDGEEAEDAYARPPAAKAARTRLGPAGGHNLNINAQPTAAPPAAAAAAAAGAVGAGVGVGAGAGTAGTAGLSLAERLSQRLDPTLLPPAAAMVAPAAAACAARTAGAAAAVAAAAAAAAGRAPVDAAVLRRLVDDIGHDEQMARKALRRTGGDYKAALNLLDFGRLSPAIERTLSSDHEAAAAGGHGTGAGGGDAGLGADFGFYGGVGAGTGVAAGTGPSLQQLAQERRQRLLERSGSGAAAGPGGVGVAAAAAQGFPGRGHGDVARVGSAGLGSENGAGGSGRLGHLLGTGSGGGSGEVLPGGATSAVGVVGKPPLPLLVDLTAAAGAAAAAAGGAGRGGAKRPPAPSVAPAAGAGVAGGGFGSQPDDAVVAGAVLGGSQRLQDSQGGLGSQGLGSSQRAGAEGLGSQGLGGSQRAGSQGLGSQGLGSQFLGSQGSDLLRAGSGMGSQRAGSQDSEGGGDGDDSKTLLSYEWALPRLCEVPAVHGELAVRLPPLAPGQRFEDVYEVVLVVDQREKDRMVEAVRRVAAGQGLRVAAGVTLGVGDFLWVAARRGSRLDQRSEWYVLDAVCERKKAADLLASVQDRRYGQQKWRLQRCGLRRLYYLLEEPIEQEGFTTTEQRTMRTSIQSALLQGFTVLRTRNADDTARQLAALTRALERQCRARSAALLAAQRQRQGAAVAAGGAARGAAGAGGAGAGAVEEADADDPLPTYEAWEEGLKSTAADMKVAAMWGLMLTAVPGMGDVAVGKVLARYSSPAQLWESYKAAMRAAAAAGSDPGAAAEQLLVPEVGARLSGQLYRLLFKKGVPPEQVAAAGGGGGGAGR
The following text describes a protein:
Function:
Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).
Subcellular Localization:
Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ.
Sequence:
MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MAGYRIWQLLFAVWAVSGSGVEVSAQFVGYYRTKDCGIAEAIVTQAVTQAFNQDPSVAPALIRLLFHDCFVEGCDASILLDPSPENPNVEKRSGPNLSVRGYEVIDAAKTQLEKTCPLTVSCADIVALAARDAIVLTGGRHFEMPTGRLDGMVSSTASADANLVSTESSARELTQKFLAQGLGQDEMITLSGAHTIGRTTCAQVTPRLYNFPGSPNGVDPTLDFDYALHLKQVCPQGGNPNSVVQLDPVSPNTFDNMYYTNGVTGRVLFASDIALFADHQTEFASNLNSENAELWQIKFSNALIHMASNKIKFGRPDEEGEIRQNCRLTNARFAATANMSRSAHNHGA
The following text describes a protein:
Function:
Cleaves adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to adenosine monophosphate (AMP) and inorganic phosphate. Enhances fibrin degradation in the midgut blood bolus. Activates human tissue plasminogen activator (PLAT), probably via an allosteric activation mechanism. Inhibits ADP-mediated host platelet aggregation in vitro and in mosquito midgut. Inhibits host neutrophil activation in the mosquito midgut: reduces neutrophil extracellular traps formation in the presence of platelets and the formation of total cell- and mitochondrial-derived reactive oxygen species; (Microbial infection) Promotes Plasmodium berghei parasite transmission from the mammalian host to the mosquito probably by reducing the blood bolus viscosity. Facilitates sporozoite transmission from the mosquito to the mammalian host during blood feeding.
Miscellaneous:
MISCELLANEOUS: Protein is mixed with the host blood and ingested by mosquito during blood feeding. A reduction in both Plasmodium berghei oocyst intensity and infection prevalence is observed in mosquitoes that feed on mice immunized with the protein prior to infection with P.berghei parasites. Immunization of mice with the protein reduces P.berghei sporozoite infectivity in the mouse skin after mosquito bite.
Subcellular Localization:
Secreted.
Sequence:
MALVRFATIITVLCHLAIQDGAAKSFPHGEKAPFPLTLIHINDLHARFDETNQKSSTCTNSKECIAGIARVYHTIKQLKSEYKTKNPLYLNAGDNFQGTLWYNLLRWNVTAYFIKELPPDAMTLGNHEFDHSPKGLAPYLAELEKMKIPTVVANLEKNGEPALKDSKIARSIVLKVGNRKVGVIGALYDKTHLVAQTGMVTLTNSIEAVRKEAQELKKKNVNIIVVLSHCGLDGDKQLAEEAGDLIDVIVGAHSHSLLLNKDAKVPYDTKYDTIEGDYPLVVKKSNNHTVLITQARSFGKYVGRLTVNFDCEGEVQSWEGYPIYMNNSVKQDEEVLRELEPWRAEVKRLGTQVIGTTEVFLDRESCRWCECTLGDLIADAYADQYTNSTVQPVAFVQAGNFRNPIEKGDITNGLAIEAAPYGSSVDMIKLSGADLWSAIDHSFTLDDEFRYNTAQVSGMAVVADLSKKPYERVQSIDIVGANGAKTALKKDQIYYVVVPSYLADGKDGFAMLKKGTNRVTGPLDSDVLIEYVRKRQTIAKTMFQEKRVVIENHTNGTCSWDLDSQRYKPK
The following text describes a protein:
Function:
Involved in the transport of molybdenum into the cell.
Subcellular Localization:
Periplasm.
Sequence:
MKKLTKISTALLIAGLGFSFAASAKVTVFAAASMTDALQQVAKDYAKQNPKNEVVFSFASSSTLAKQVEEGAPADIFVSASNKWMKYLSEKDLTVKETEKVLVGNDLVLIAPAKSAVNSVDIAKGEWINALKDSYLSVGDPAHVPAGQYAEEALTKLNLWDKVKDRLARGKDVRGALALVERAEAPYGIVYSTDAKVSQQVKTVAVFPADSHKPVVYPVSIVKGHDNADSRDFLKYLESDAAKKVLVGYGFSAK
The following text describes a protein:
Function:
Required for vacuolar assembly and vacuolar traffic.
Subcellular Localization:
Vacuole.
Sequence:
MTDTNISKESNEITAENEHEESIVKDLDDASVNEAIPAAQPETDEKQHHEGDHTSIEEDGDEDEEEEEEEEPPTLKYTRLNKLPANFFVKDPVSTSTFHETVFIFATHSGIIHICKPNFETIRTFKAHRASVLSVFTDGTYFATASMDGTVVIGSILDEKDIVAYDFQRPVHAVILDSNYYKTRSFISGGMAGQVIYSSKGWLGKRSDFVLEQGHGPIVSIQLIDDLVIWMNDKGISVFHLATRQIISVLEKPEDSPRSDLYWPRIAFPDPDRLIIGWSNYIWSLRVSLKTAQDEKEGTPISSGMSKILPSTASISFRAVQEKKVEVEHIFKLDSLISGIASFKDDLWMVLAYTPPEADAETGKKTFFNPDLKLINSTTGEVELEEELGLKEIANLGLNDFMLGTHIETIPKYYIISAKDGVIAEEFQISDRLEWYLDRKNYLQAWEISQHLVTPTKRLSYGILYVDSLIEEDNWEEAATFLQRLLVIKRDPNEIKSITQISTESNEEDLDKEILDYWETWSTIFINSNHVQELTNIIPNVTGLLPTSIYDTILRFWLKKDASRFKTLIELWDPSLYNISDIASELELEAKENETLERSLVTLYDKSHNPSKAVPHLIHLRDPNIIGYLSTNHILVPFVSELPVMIDLMFDKGDLKTLPVSKIEKRLQGVISILVDHRLEIPAKQIVNLFYESGLSFVSFFYLEKLADIDNFLVQGFGNERVKLYADYKREKLLPYLTKNDDYDIDTAITICETNDYTKELVYLLGKIGENKQALTLVINKLEDPVMAIEFAKHQNDKETWDILLDQSMSKPKFIKALIESSDESSNAFYDPITILQRMPQDFKIEGLNESVIEFSKNNDLNMLLNQIILKIIYKQSQETSEEFKSQKLRGFEVEIDKKIKKMIQQFQTIVAFVRDDNVKGGPKVVDIKLESDLTSDYSMVPYRDLAHKLDHLREIEENYF
The following text describes a protein:
Function:
DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own.
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPX being less stably bound at the kinetochore than CENPS.
Sequence:
MEGAGAGSGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVVEAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MATPVDLELKKAFTELQAKVLDTQQKVKLADLQIEQLNRTKKHAYLTGAEIKTLSDSTPMYEGVGRMFVLQTKDTIHNQLLNKQKVADEKIAELEQKKTYLERSVKDAEDNIREMLMARRAQ
The following text describes a protein:
Function:
Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.
Sequence:
MSAGVTFTLSNGVKIPAVGFGTFASEGAKGETYNAVTCALKTGYRHLDCAWFYQNEDEVGDAIQDFLKENPSVKREDIFICTKVWNHLHRYEDVIWSLENSLKKLRVDYVDLYLVHWPIAAEKETQEKPKIGPNGKYVILEDLTKNPEPTWRAMEKLYEEGKAKAIGVSNWTIEGLEQLLKFAKVKPHVNQIEIHPFLPNEELIQYCFKHDILPEAYSPLGSQNQVPTTGERVSENPTLNEIAKKGGNTLAQVLIAWGLRRGYVVLPKSSNPARIESNFKSIQLSDADYEAVNNVAKGRHFRFVNMKDTFGYDVWPEETAKQMSA
The following text describes a protein:
Function:
May be required for cytoplasm to vacuole transport (Cvt) and pexophagy.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Note=Endosome and other perivacuolar punctate structures.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.
Sequence:
MSDFEDNNPFAGADRRDSVSSDATDDGPSASFLATNTTNDFGGASFMAGGGSFYGAASQIGGLGGMGMSAYDPESALANPFDDGSNSFSATPTASITNQNDTAHEATNERTTTASQSNIPPIEIIEANKNHEGTSRGFITYTIRVGDVSVRRRYSEFESLRTTLTRMFPTLIVPPIPEKHSITDYAVAPTKAREDKDMIEHRQRMLQVFLNRCRNLPQISNCIVFQRFLDPHASWSEVLNSPPVSTLPRYSLRAPPVDPSNNVTEAHSYLPIPSANGVVRNRGGDEEGKQEAFFAEAEKTAKEYEAVIGGGLEKVARRILKRYTDIAGDYAELGGRFNALSLEESDSRMAATVEKVGQAIDSNYLATNHLVRELGRQFGEPLAESAQFSGVVRSVLKYRKQKALQLELTSDSLEAKRVTLASLESAEADSQRINDALGRTRSNNGPSTTNSGEQPSASPAPKKSSGFKIPGLSSLNSAFNNMMDADPEASRRQGIGKTREQIGQLEQALEVAQKDIVVANESVEKDLERFRAEREADLKCMIRAFLKCHIDWAKQNLDTWQSAQAEVESM
The following text describes a protein:
Function:
Histone reader involved in homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. Specifically recognizes and binds histone H3.1 lacking methylation at 'Lys-27' (H3K27me1). Involved in structural and functional stabilization of chromatin; represents a link between response to DNA damage and epigenetic gene silencing. Required for cell arrangement in root and shoot apical meristems. May be involved, when interacting with TSA1, in the organization of spindle microtubules.
Subcellular Localization:
Nucleus, nucleoplasm. Chromosome. Note=During anaphase, relocalizes in spots close to the ends of spindle microtubules ahead of separating chromatids.
Sequence:
MGRLDVAAAKRAYRKAEEVGDRREQARWANNVGDILKNHGEYVDALKWFRIDYDISVKYLPGKDLLPTCQSLGEIYLRLENFEEALIYQKKHLQLAEEANDTVEKQRACTQLGRTYHEMFLKSEDDCEAIQSAKKYFKKAMELAQILKEKPPPGESSGFLEEYINAHNNIGMLDLDLDNPEAARTILKKGLQICDEEEVREYDAARSRLHHNLGNVFMALRSWDEAKKHIEMDINICHKINHVQGEAKGYINLAELHNKTQKYIDALLCYGKASSLAKSMQDESALVEQIEHNTKIVKKSMKVMEELREEELMLKKLSAEMTDAKGTSEERKSMLQVNACLGSLIDKSSMVFAWLKHLQYSKRKKKISDELCDKEKLSDAFMIVGESYQNLRNFRKSLKWFIRSYEGHEAIGNLEGQALAKINIGNGLDCIGEWTGALQAYEEGYRIALKANLPSIQLSALEDIHYIHMMRFGNAQKASELKETIQNLKESEHAEKAECSTQDECSETDSEGHANVSNDRPNACSSPQTPNSLRSERLADLDEANDDVPLISFLQPGKRLFKRKQVSGKQDADTDQTKKDFSVVADSQQTVAGRKRIRVILSDDESETEYELGCPKDSSHKVLRQNEEVSEESMYFDGAINYTDNRAIQDNVEEGSCSYTPLHPIKVAPNVSNCRSLSNNIAVETTGRRKKGSQCDVGDSNGTSCKTGAALVNFHAYSKTEDRKIKIEIENEHIALDSCSHDDESVKVELTCLYYLQLPDDEKSKGLLPIIHHLEYGGRVLKPLELYAILRDSSENVVIEASVDGWVHKRLMKLYMDCCQSLSEKPSMKLLKKLYISEVEDDINVSECELQDISAAPLLCALHVHNIAMLDLSHNMLGNGTMEKLKQLFASSSQMYGALTLDLHCNRFGPTALFQICECPVLFTRLEVLNVSRNRLTDACGSYLSTIVKNCRALYSLNVEHCSLTSRTIQKVANALDSKSGLSQLCIGYNNPVSGSSIQNLLAKLATLSSFAELSMNGIKLSSQVVDSLYALVKTPSLSKLLVGSSGIGTDGAIKVTESLCYQKEETVKLDLSCCGLASSFFIKLNQDVTLTSSILEFNVGGNPITEEGISALGELLRNPCSNIKVLILSKCHLKLAGLLCIIQALSDNKNLEELNLSDNAKIEDETVFGQPVKERSVMVEQEHGTCKSVTSMDKEQELCETNMECDDLEVADSEDEQIEEGTATSSSLSLPRKNHIVKELSTALSMANQLKILDLSNNGFSVEALETLYMSWSSSSSRTGIAQRHVKEETVHFYVEGKMCCGVKSCCRKD
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.
Subcellular Localization:
Nucleus.
Sequence:
MSSKDMSLDELKDLQKQLSKLATSSDSEAILSIFSKLKSGLSAPTEDVIRQSKIGVAVGKMRSHSDKKVADQAKSLVKDWKAIVDKQRAQSSANSSKAPSSTASPAPTTSKPDGTINGNGTASASPASTPSAAAKSTSSTKIDFEILNDKVRNACLKLLYQSLEIGKESHVWNDSQIFDAAVAVEAAILSNQGKGSVTADYRNKVRSLSLNIKDKNNPDLRVRVVEGDIAADKLVTMTNEELASDKRKREIEELQMQNLFKAKGAAAQEAETDAFQCGRCKQRKTRYYQMQTRSADEPMTTFVTCTNCNHKWKFC
The following text describes a protein:
Function:
Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.
Miscellaneous:
MISCELLANEOUS: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.
Sequence:
MKVTLSALDTSESSFTPLVVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLNKYEQETLENQNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDDNNDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFPLHDSEALKKLEDTWYTRFALKYQPIDSIRGYFGETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDYDKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFEEPRPGFHGVLGINSITGKEEPLYPSYKRQLRIYLVSLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLYVPSIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKDMKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQALKADIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMSPQVNAVFPESKADLILIVVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENLKEEPMESGKEKAT
The following text describes a protein:
Function:
Involved in sequestration of excess metal in the cytoplasm into vacuoles to maintain metal homeostasis.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Sequence:
MESPESFSTMFMKPIRHILSEKKSRKIALFLLINTAYMVVEFVAGFMSNSLGLISDACHMLFDCAALAIGLYASYISRLPANHQYNYGRGRFEVLSGYVNAVFLVLVGALIVLESIERILDPQEISTNSLLVVSVGGLLVNIVGLIFFHEEHHHAHGGSGIFLHVLADTMGSVGVVISTLLIKYKGWLVADPASSIFISILIIASVIPLLRNSAEILLQRVPRAHRQDLKEAMRNILKTKGVCSIQRLHVWSFTNSDVVATLHLLVSADSDKTDTKLQVSRLLEDAGVKDWTLQVESVNS
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Sequence:
MKLGVLGSTGSVGSQTLQVYENFRDEIELVGILANRASEKLLQQAKKYKPKYVVSYQEPAKEWLESLPEGVKYLKGDEGLKAIIEESERLMNAISGIYGIKPAYEVIKAGKTLLASNKESILCLGEIIRKNRERVIPVDSEHNALFQLLSSVKREEVKHVYLTASGGPFKDKSLEELKTASVEEALRHPRWNMGAKITIDSATLMNKGFEMLEAHFLFDFPIENIKVVIHPQSFVHGILELIDNSFLMHTSQTDMKIPIMHALFYPKRKEYPFKKVSLLELSPITFEKVDTTKFKAIDLAKWAGFMGGVYIPVLVGADEEAVNLFLNKKIGFLDIVDLIEQALSEVNIKDPQSVEEILEAVEWGRQKVREIYERKYAGKG
The following text describes a protein:
Function:
Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration (By similarity).
Subcellular Localization:
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia (By similarity).
Sequence:
MSSAPPRSPTPRAPKMKKDESFLGKLGGTLARKKKTREVTDLQEEGKSAINSPMAPALVDIHPEDTQLEENEERTMIDPTSREDPKFKELVKVLLDWINDVLAEERIIVKQLEEDLYDGQVLQKLLEKLAHCKLNVAEVTQSEIGQKQKLQTVLEAVQDLLRPHGWPLRWNVDSIHGKNLVAILHLLVSLAMHFRAPIHLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEIMMGRFERDAFDTLFDHAPDKLNLVKKSLITFVNKHLNKLNLEVTDLETQFADGVYLVLLLGLLEDYFVPLHNFYLTPDSFDQKVHNVAFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYTLFTKYKDVE
The following text describes a protein:
Function:
Pseudouridine synthase that catalyzes pseudouridylation of RNAs.
Sequence:
MLKRPKRDPLKDCEYVFKGDGLRRVPPYYYEYITFAKLRWYGKTLLEVFNTEFRDRESGYYEKAIRNGQVKVNNQIGNVDTLIENGYIVSHHAHRHEPPVSDQPVGIVHEDESYVVIDKPAGVPVHPTGRYNHNTVLHILMKENKCSLLYPCNRLDRLTSGLMFFSKSPKAAEEMRVHMISKSLKKEYVARVIGEFPNSGEVICDAPLLTVAPTLGLNRIHPDGKEASTVFKRIAFDGHTSLVLCKPLTGRTHQLRVHLQYLGYPIANDPIYANKRVWGPSLGKNGEGSNESVIMRLSEIGKTETASPLLQYEWYTNETEAEAKARRDKRLGELLTGKHCSECGTPLYSDPSPEELGIWLHALKYESKDWSYKTQLPKWALDVCCRDPNALPIE
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MDVDVEEAALEQVAALLQRPDQLEKLPELKKRADRKKLAVEAMLRTGVQGQLEGIRTAIAHLQTASDDITAISQGVHDIRERLGPFPQLKEKLRELRDANARHGQYAAAMENLKHIFNLQTTLQEIRDALDDEKSGGNLLLAHKHIMDLERARDELLAEVHKMSGTNTEKEQMLLVNFFKGVDSVVAELSKNMWFILGRTLEMVKGNEQGGGPQQVVTCLRIVEREERIDKFYMEARSKNSSAFVPPGRPRNWKEKALRSLEKTVSNRVDGNQLEDRSLNKAWLARYLEVCKNVIMDDLQLAKVAIPCFPPDWQIYDRYVHMYHTSVCRRLREVASEHLEKSELVQLMSWIKFYASEDMLGHPKLRINAQAILQDSPVLSRSTLNQLCDQFVEMSRDDLKLWLKNTVSHETHDWYKNLRPSEDNHGYFYTDLPNTVFGMLKDTVTLAKEVSVEVIPSIINLTIQEFNELAGKYRDAFTAYKTDYFAERSKYQEFTSNIIAIANNLHTCIESTEKYKQQIRLSMEGEQNAAAAMTTPLASGRRTAVRQQQLIENMDALNTKWSNAASVAVNYLREEVITDIAPSLVEIFSKKWLTGSAALETVCMTISDYYHDHKHLRPVTRSTLLMDLQFRIVSEYLKAIETKRVSLNSYEERALAGKRMKADVVRLDNLYAEFATSSDMADQLPLLTSIVAAAGDVISLKDKSLLSLEATSFARKFPNCPAELLSAVIATRDDISGSEARSLASEVLQHVQFHPKDQIFDQLFALRQQENSERLPNLGMANMFKADFMSMLKRDA
The following text describes a protein:
Function:
Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity. Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
Subcellular Localization:
Nucleus.
Sequence:
MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPAKSKKPSSKGKRKESCSKHASGTSFHLPQPSFRVVDTGSQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDIAWLDMVNEKRRADGHSSVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCVLCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTTFTVRKTAYCEAHSPSVAVARRKGDSPRSLSEVGDEDGPKEGGGEEEQEEAEEEGQEGQGGVGSPLKGVSKKGKMSLKQKIKKEPEEAGREAPSITLPMVTVPQIPSYRLNKICSGLSFQRKTQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFTVLLRTTLDLLQEKDSAHIFAEPVSLSEVPDYLEFISKPMDFSTMRRKLESHLYHTLEEFEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPRLEDFYRFSWEDVDNILIPENRAHLSPEAQLKELLEKLDLVSTMRSSGARTRRVRMLRREINALRQKLAQPPPPQLLSLNKTVPNGELPAGSRGDTAVLEQAQQEEPEEEGDRDDSKLPAPPTLEPTGPAPSLSEQESPPDPPTLKPISDSKPSSRFLKSRKVEDEELLEKSALQLGSEPLQCLLSDNGIDRLSLTNPDSHPDTPLGTVGRRTSVLFKKAKNGVKLQRGPDGTLENGEDHGPEDDPASPASTEDEHYSRKRPRSRSCSDSEGERSPQQEEETGVTNGFGKHTESGSDSECSLGLSGGLAFEAGSGLTPPKRSRGKPALSRVPFLEGVNGDSDHSGSGRSLLMPFEDHGDLEPLELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGERLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGSHAFVTSSYL
The following text describes a protein:
Function:
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Contributes to replication in macrophages. Plays a role, cooperatively with SopB, in membrane fission and macropinosome formation during invasion.
Subcellular Localization:
Secreted. Host cytoplasm. Host cell membrane. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 T3SS), and delivered into the host cell (Probable). Membrane-associated in transfected cells. Recruited to the bacterial invasion site, and this recruitment requires the phosphatase activity of SopB.
Sequence:
MPVTLSFGNHQNYTLNESRLAHLLSADKEKAIHMGGWDKVQDHFRAEKKDHALEVLHSIIHGQGRGEPGEMEVNVEDINKIYAFKRLQHLACPAHQDLFTIKMDASQTQFLLMVGDTVISQSNIKDILNISDDAVIESMSREERQLFLQICEVIGSKMTWHPELLQESISTLRKEVTGNAQIKTAVYEMMRPAEAPDHPLVEWQDSLTADEKSMLACINAGNFEPTTQFCKIGYQEVQGEVAFSMMHPCISYLLHSYSPFSEFKPTNSGFLKKLNQDYNDYHAKKMFIDVILEKLYLTHERSLHIGKDGCSRNILLT