lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MADFGDFASGIEGTTDAGSFMNDILGDSSIDPTADFLAREQAILGADTAALFGNTSPIATHNSGFASTQSVVASTTSTAAVGDLGFEILSAGSVPTPAAMAPFATVSGASLPLSSTSPTPAFGVFDQQHALGSEMDAPIFDESAFPEVSAIGVPGMSVFSTQTGASSMGLPMNVPEIEPEAVREWRERFNAVVAERDAKSKDKHDQILQQAKEHLEKLYAEYSEKKAKSISRNKDLEKTLLAARDEATSGTVWDRALKQIDSAQLTSKDKKSDDKKDKKAASANAAPKVKGPDTTRFKQLLISLRNDKKAPVI
The following text describes a protein:
Function:
Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
Sequence:
MISVEEAQALILEAVEVGAPERVDLLAACSRVLAETILARTDFPPYDNSAMDGYAVRSADTGFGKLQVVETIAAGRMPTHPLAEGQAARIMTGAVLPEGSDAVLIQEEARLEGDTLTFEKLPAPGANVRYRGAFHKAGSPLMPPGTVLQPGEIALLAAAQRAFVLTHRPPAVAIVSTGDELVGIDGVLAGARIVDSNQYGLVAQVREAGGDPRALGIAPDDPEAIRMRLLAALDADFVLLSGGASVGQFDYTPQVLEALGAQVVLYKINMKPGKPLMFARLGSRLIWGLPGNPVSSLFCFWQFVRPAIRKFMGYPPERWRYPVVTAQLKAPVRSKGDRRAYLRGQLALEAGVWRFAPYRTDNSGDLVSLLGINAFAWLEAGVTGACEGETVPVLVVGELVNR
The following text describes a protein:
Function:
No alpha-1,4-glucan hydrolase activity, including beta-amylase, alpha-amylase, a-glucosidase or alpha-amyloglucosidase. However, facilitates or regulates starch breakdown, especially at night, by a mechanism involving direct interaction with starch or other alpha-1,4-glucan.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MTETGVIGCGCRGVTGGNFFHPGGFSLKSCFLEQSTKRNRNFFRSVSMIPPFKRGRFITKLRSVAGNSRIFSMDAREKSRSFVLVSSRHKRVPVFVMMPIDTFGIDASGCPKIKRLKALTVSLKALKLAGVHGIAVEVWWGIVERFSPLEFKWSLYEELFRLISEAGLKLHVALCFHSNMHLFGGKGGISLPLWIREIGDVNKDIYYRDKSGFSNNDYLTLGVDQLPLFGGRTAVQCYEDFMLSFSTKFEPYLGNVIEEISIGLGPSGELRYPAHPSGDGRWKFPGIGEFQCHDKYMMEDLMAVASQEGKPQWGSRDPPNTGCYNSFPSGVPFFEEGNDSFLSDYGRFFLEWYSGKLICHADAILAKAADVLRRRQEEEKSSVMLVAKIGGIYWWYKTSSHPAELTAGYYNTSLRDGYDPVASVLSRHGAALNIPCLDMADSEIPEKYLCSPEGLRRQIHDVSKKWTIHVTGRNTSERFDEMGLRQIRENCVQPNGDTLRSFTFCRMNEKIFRVENWNNFVPFIRQMSADM
The following text describes a protein:
Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSIQKLNDTTNSGYVSSEETDSLLVSSSNPSKGGGRTALLRQVKSNSTNGPTTGASTSSSGSVSGGGGGSGSGGGSASGSAAGASKPTLMRQDRTSTYLTSPQQSQHARMGSEESMRGGASGAAGHDEDVEQGLVRSSIVPDIEVHEEDQEQHSQQLNATTMATMTNNQQQQQPTISIMNLSLKPGDSHSHSSSPGSHPNLGTSSYQNLASSIPPSVPSRCRACRNCSRRASTTPTTLIDRSASRDSVKSAFQQGNLSGSMAICISNSALPQQQQLQQQYHLQQQQQQHYQLQQHHLHQQQLQQSQQQVPPVLITSSPTNGSRIIRQSSQPESSSTAICCGPHSACVGHAHSHSHTVPNVSLKQLRESSGDGIAGIAADSLRINGGMRPFKQLRKPASTLSIPGSMKTPSIANREQISSGCNEEAAEALVGIHSDYPRYEMYMEERALTGGNTSRKPSTNSAKHKPNVGYRLGKRKALFEKRKRISDYALVMGMFGIIVMVIENELSSAGVYTKASFYSTALKTLISVSTVILLGLIVAYHALEVQLFMIDNCADDWRIAMTWQRISQIGLELFICAIHPIPGEYYFQWTTKLANKNKTIGTEMVPYDVALSLPMFLRLYLICRVMLLHSKLFTDASSRSIGALNRINFNTRFVLKTLMTICPGTVLLVFMVSLWIIASWTLRQCERFHDEEHANLLNSMWLTAITFLCVGYGDIVPNTYCGRGITLTCGMVGAGCTALLVAVVSRKLELTRAEKHVHNFMMDTQLTKRLKNAAANVLRETWLIYKHTRLVKRVNPGRVRTHQRKFLLAIYALRKVKMDQRKLMDNANTITDMAKTQNTVYEIISDMSSRQDAIEERLTNLEDKMQSIQEHMESLPDLLSRCLTQHQERIEQRRNFLHPDTAAVAPIQAPTPQSMFNAAPMLFPHSS
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MENVGVGMPFYDLGQTRVYPLLSDFHDLSAERYPVGFMDLLGVHRHTPTHTPLMHFPTTPNSSSSEAVNGDDEEEEDGEEQQHKTKKRFKFTKMSRKQTKKKVPKVSFITRSEVLHLDDGYKWRKYGQKPVKDSPFPRNYYRCTTTWCDVKKRVERSFSDPSSVITTYEGQHTHPRPLLIMPKEGSSPSNGSASRAHIGLPTLPPQLLDYNNQQQQAPSSFGTEYINRQEKGINHDDDDDHVVKKSRTRDLLDGAGLVKDHGLLQDVVPSHIIKEEY
The following text describes a protein:
Function:
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. ppk26/pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The N-terminal zinc finger binds to poly(A) RNA; Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of pan2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs; The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for pan2.
Sequence:
MSVRKNSPASPKPTSRSRESSRSPSVTDLKDHSKAKRTLCRNILLYGSCKHSENGCAFRHDGPFIPSSENLEQYSVKKKLNAASASFQPVRALPVKAAGAAVFVPKSQEKSLFLSRERTPVALSPGSHAINPYNNASMLVNEPFHDDSGVYYTRQNQFKPTLYNLYNPQPSPMPTLLPYERTVNGLFIDDTTRERIERKSEASRQTISALPSIISSYTSLAPLNTKLYRYKEQIGFSSWTYKCTSSIDGNAYVLKRLQDCSINIDTSTVDKLKNVFHPNIVPFHSAFHTDTFHDSSLLLIYDFYPCTTTLGELYLNNSKNSVKLEENRKIPERELWNYFFQLTIALSYLHKSGFACNKLTPSRILVDQTERIRISGCADYELVVSNKPPLEERKKQDFVDLGVVIANLATGRTDMDMSSAARAIYSTYSREFYKAVLYFVSEVPEDKNLELFLQNHIESFFPIMSSPYVECEKMERKISDAFQHGRFFNILCKIMFIIDNNRASREYPIAREKEISLIYLLRDYLFHQIDEDECPVIDLYQVLNRLGKLDAGINQAIALISRDELDCVSVSYGELKAWLDNVYEMEINS
The following text describes a protein:
Function:
Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Upon TGF-beta induction, forms a transcriptionally active complex with smad2 and smad4 called activin-responsive factor 1 (ARF1), which binds a site on the mix-B/mix.2 promoter called the activin response element (ARE). Binds to activated smads and the ARE with much lower affinity than fast3. Necessary for the first steps in mesoderm specification, directly inducing mesodermal genes. Acts with fast3 to control the convergent extension movements of gastrulation. Binds to the proximal element (PE) of the gsc gene and cooperates with gtf2ird1/wbscr11 and SMAD proteins to regulate gsc transcription.
Subcellular Localization:
Nucleus.
Domain:
The FM region is required for binding smad2/smad4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated smad2 that is in an activated smad complex.
Sequence:
MRDPSSLYSGFPAGSQYESVEPPSLALLSSIDQEQLPVATGQSYNHSVQHWPQPWPPLSLYREGGTWSPDRGSMYGLSPGTHEGSCTHTHEGPKDSMAGDQTRSRKSKKKNYHRYNKPPYSYLAMIALVIQNSPEKRLKLSQILKEVSTLFPFFNGDYMGWKDSIRHNLSSSDCFKKILKDPGKPQAKGNFWTVDVSRIPLDAMKLQNTALTRGGSDYFVQDLAPYILHNYKYEHNAGAYGHQMPPSHARSLSLAEDSQQTNTGGKLNTSFMIDSLLHDLQEVDLPDASRNLENQRISPAVAMNNMWSSAPLLYTHSKPTRNARSPGLSTIHSTYSSSSSSISTISPVGFQKEQEKSGRQTQRVGHPIKRSREDDDCSTTSSDPDTGNYSPIEPPKKMPLLSLDLPTSYTKSVAPNVVAPPSVLPFFHFPRFTYYNYGPSPYMTPPYWGFPHPTNSGGDSPRGPQSPLDLDNMLRAMPPNKSVFDVLTSHPGDLVHPSFLSQCLGSSGSPYPSRQGLM
The following text describes a protein:
Function:
Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU (ISU1, ISU2 or ISU3). In a second step, the cluster is released from ISCU, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLRYVGNRIPGLGQRRSSSAVAQGVYRRLYHERVVDHYNNPRNVGSFDKNDPAVGTGLVGAPACGDVMKLQIKVDEKTGKITDACFKTFGCGSAIASSSLATEWVKGRTMEEALSIKNTEIAKHLFLPPQKIHCSMLAEDAIRAAKKDYEAKKAKFNENAEKSV
The following text describes a protein:
Function:
This protein binds to 23S rRNA in the presence of protein L20.
Sequence:
MVYAIVETGGKQVLVQPGRFYDVELLALDVEAALTFDKVLLVRHEGGAVVGRPTVEGAAVQGRILQHGKAAKVTVYKMRPKKGYRRKKGHRQRFTRVMIESIDFEGRSFTAEAKAEAVSST
The following text describes a protein:
Function:
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.
Sequence:
MAEMNTNRFTIGYALLLKKQQSFIQDSLINSAKQRGIDLIKIDTDKPLADQGPFDCVLHKLSGNDWRNQLREYVIRNPSSIDEVKDIDETASFGVPKQVVVYEPEKLSEGLGLSLKFPVIAKPLVADGSAKSHKMLLIFSSEGFEKLKTPTVLQEFVNHGGVIFKVYVVGKYVKCVKRKSLPDIDDEKLESLRGSLSFSQVSNLTSDERNDDKYYKMMDSEDAAMPPMNLISNIARGLRKAMKLHLFNFDVIRDTKVGNRYLVIDINYFPGYAKMPGYESVLTDFFWDILNKKEDRFFDCEKELMKLVGDDGGCDEDTVCPNVSSA
The following text describes a protein:
Function:
DNA polymerase alpha mutation suppressor.
Miscellaneous:
MISCELLANEOUS: Present with 259 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MDLPTVNSTTSISDNVDLKNYYEDLLFKNNSGKSLSDLPRKLNDNSNNSGSDTVDPLAGLNNLRNSIKSAGNGMENRRTFDDIDFMGRFPYLPPVPNQQQQPFSHQNGFIQEHPSSNLTSFQMSSSNSEPMSAPPISSNNNNLNSTQMGNYQAQQRSFPQFNGNSFHSNGNDLMGNRMDSDYMRLMNKTNIGFTSNSGSNFAAPSHSAGNPSSMNNQQVPSFNWQQPSHPESTIRRSSYISDTLINHQMPDARQKQTSQVQQQHAQGFNLFNSRFNYDNLNSTHLTAKGVPEFGNGVQPPYPYDNEPNNASISNSNNNNNSHNMVPMQQFRRNTQPVASFNPSLPTFQQQQQQPQQPQQPRNVNVPTSFNGERVDDVQLVQLQRSSSVPSSTNSHNLQNENSNEGNVSLDNGLVLIQGKHLTSSKTLHDLYSDCGSGYFASSAVFEFTDNIKKMLKLHDSNESYDAKNMGLIDEEGNTYQSLLNFLDILRSCNMNYVNDPESNNGIVSNNGGNKNRRKGSFTTELSCRNANNSFLPYTPLVLVALKNGKLELLSTPQATNLLLKRGDLVIIDGDRGRDLVLVVEPSVDLNLALFINFLKKKIHFDSLITSESQHYRNDEFIQMLIDSKNGQKKKLNPKLYDVVELTELIIPSKQVLRFATPWEVTTNLHNKFEDELKALHIAQSKLQALNDNSKSQNTNDSSSNNFTNAATYSKPKLNIKILNAEFQFDRKKLTFYYVCEERNDFRDLIKELFKYYKTRIWLCAIPNNLSIDSKYYDKQQKELKLYQNIVKNYNAEDLMNVNEFSQNRGNNRVNFAPPLNEIELDNFQIAVYEELVHELFH
The following text describes a protein:
Function:
Serine protease that performs the primary cleavage of the photodamaged D1 protein in plant photosystem II.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Sequence:
MAASVANCCFSVLNASVKIQSSSISSPWCFVSASSLTPRASSNIKRKSSRSDSPSPILNPEKNYPGRVRDESSNPPQKMAFKAFGSPKKEKKESLSDFSRDQQTDPAKIHDASFLNAVVKVYCTHTAPDYSLPWQKQRQFTSTGSAFMIGDGKLLTNAHCVEHDTQVKVKRRGDDRKYVAKVLVRGVDCDIALLSVESEDFWKGAEPLRLGHLPRLQDSVTVVGYPLGGDTISVTKGVVSRIEVTSYAHGSSDLLGIQIDAAINPGNSGGPAFNDQGECIGVAFQVYRSEETENIGYVIPTTVVSHFLTDYERNGKYTGYPCLGVLLQKLENPALRECLKVPTNEGVLVRRVEPTSDASKVLKEGDVIVSFDDLHVGCEGTVPFRSSERIAFRYLISQKFAGDIAEIGIIRAGEHKKVQVVLRPRVHLVPYHIDGGQPSYIIVAGLVFTPLSEPLIEEECEDTIGLKLLTKARYSVARFRGEQIVILSQVLANEVNIGYEDMNNQQVLKFNGIPIRNIHHLAHLIDMCKDKYLVFEFEDNYVAVLEREASNSASLCILKDYGIPSERSADLLEPYVDPIDDTQALDQGIGDSPVSNLEIGFDGLVWA
The following text describes a protein:
Function:
Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MDRRPLTWALVLLGPALAIALGPAAAQEAPEKLCGHHFVRALVRLCGGPRWSSEEDGRPVAGGDRELLRWLEGQHLLHGLMASGDPVLVLAPQPLPQASRHHHHRRATAINPARHCCLSGCTRQDLLTLCPH
The following text describes a protein:
Function:
Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Transfers mannose, the terminal pentasaccharide residue, from its dedicated dolichol phosphate carrier to the protein-bound glycan comprising the first four subunits of the N-linked pentasaccharide.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKRLAKAAFSQNSLTAPIVSTFVYLISVVRVVLNGNWPVTSSDTAMFQHIGWMVFSGKRYYIDAWDPKPPLTLELATIIAYISNGDPHLQHTLSVVSTIVAGILLTYLISHITSEITGNQFAGLLSGIVFITFPVIHYSAVFGYEPKYFVFLFGLGSIYLSRNPKPILSGAAAAASAGMWQFAIIFPIISFGIISRRKSKDLILKYVFGATIIAFISLLPIYLQGGLVAMTVEVIIAPLYAGETQSFLYRLVKGVTHLKLMIPIALLGMAGILLGFLDDIRERWWVVGLLLWFCIQIFILDYDGADDLFLGIILVSMGIGFAFEKLSTKYESERINSIVTAVVVCMLIWQVVTLGGVGVITNPYSYSGDGPDQAILESGIQQFAHLSGYTEYTIGGSPPDEQYNVKSRYGPDKIEELFFTSTIPSTCHYRLSGMELEWMNLTEQSFTEEKCGKWRLP
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAGMEVEFDETVANQFSCKRCDRTFRSKRDQTLHRQEVHNHNKTTYECKLCAKSFCNSGNLDRHMKVHNDVRPFVCNICSKAFAQAVNLQRHYAVHSGERPFTCNFCNKSFTQQSNMKRHKMTHTGEKPFRCQRCGRYFSQLVNLKKHKLGHLNAKPYQCNYCEKGFTQLSNFKRHLQSHIKEGVDVDVPASIQAAAALARERLESEQKPSFFECMVCRAIFDTFADYEKHEAKCHEDHERAQLEVNQMSHMHPDDYLPMKFAVPDLDTHEIIIETTH
The following text describes a protein:
Function:
Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Binds glycine betaine and proline betaine with high affinity.
Subcellular Localization:
Periplasm.
Sequence:
MRHSVLFATAFATLISTQTFAADLPGKGITVNPVQSTITEETFQTLLVSRALEKLGYTVNKPSEVDYNVGYTSLASGDATFTAVNWTPLHDNMYEAAGGDKKFYREGVFVNGAAQGYLIDKKTADQYKITNIAQLKDPKIAKLFDTNGDGKADLTGCNPGWGCEGAINHQLAAYELTNTVTHNQGNYAAMMADTISRYKEGKPVFYYTWTPYWVSNELKPGKDVVWLQVPFSALPGDKNADTKLPNGANYGFPVSTMHIVANKAWAEKNPAAAKLFAIMQLPVADINAQNAIMHDGKASEGDIQGHVDGWIKAHQQQFDGWVNEALAAQK
The following text describes a protein:
Function:
May bind RNA.
Sequence:
MKRVNSCVKSDEHVLEELETEGERQLKSLLQHQLDTSVSIEECVSKKESFAPGTMYKPFGKEAAGTMTLSQFQTLHEKDQETASLRELGLNETEILIWKSHVSGEKRTRLRATPEAIQNRLQDIEERISERQRILCLPQRFAKSKQLTRREMEIEKSLFQGADRHSFLKALYYQAYHKKTSADKYMTSMKRKIKLGTKDEPQKKNKGDPMNNLESFYQEMIMKKRLEEFQLMRGEPFASHSLVSATSVGDSGTAENPSLLQDKGKQAAQGKGLSLHVTKVIDNSPEQCWTGPKKLTQPIEFVPEDEIQRNRLSEEEIRKIPMFSSYNPGEPNKVLYLKNLSPRVTERDLVSLFARFQEKKGPPIQFRMMTGRMRGQAFITFPNKEIAWQALHLVNGYKLRGKILVIEFGKNKKQRSNLQAASVIPSATDKSTEISGS
The following text describes a protein:
Function:
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Subcellular Localization:
Cytoplasm.
Sequence:
MMKANVTKKTLNEGLGLLERVIPSRSSNPLLTALKVETSEGGLTLSGTNLEIDLSCFVPAEVQQPENFVVPAHLFAQIVRNLGGELVELELSGQELSVRSGGSDFKLQTGDIEAYPPLSFPAQADVSLDGGELSRAFSSVRYAASNEAFQAVFRGIKLEHHGESARVVASDGYRVAIRDFPASGDGKNLIIPARSVDELIRVLKDGEARFTYGDGMLTVTTDRVKMNLKLLDGDFPDYERVIPKDIKLQVTLPATALKEAVNRVAVLADKNANNRVEFLVSEGTLRLAAEGDYGRAQDTLSVTQGGTEQAMSLAFNARHVLDALGPIDGDAELLFSGSTSPAIFRARRWGRRVYGGHGHAARLRGLLRPLRGMSALAHHPESSPPLEPRPEFA
The following text describes a protein:
Function:
Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.
Sequence:
MMKIQIYGTGCANCQMLEKNAREAVKELGIDAEFEKIKEMDQILEAGLTALPGLAVDGELKIMGRVASKEEIKKILS
The following text describes a protein:
Function:
Seems to play a role in the regulation of flowering time in the autonomous flowering pathway by repressing FLOWERING LOCUS C expression.
Subcellular Localization:
Nucleus.
Sequence:
MDAFKEEIEIGSSVESLMELLDSQKVLFHSQIDQLQDVVVAQCKLTGVNPLAQEMAAGALSIKIGKRPRDLLNPKAVKYLQAVFAIKDAISKRESREISALFGITVAQVREFFVTQKTRVRKQVRLSREKVVMSNTHALQDDGVPENNNATNHVEPVPLNSIHPEACSISWGEGETVALIPPEDIPPDISDSDKYFVENIFSLLRKEETFSGQVKLMEWIMQIQDASVLIWFLSKGGVLILTTWLSQAASEEQTSVLLLILKVLCHLPLHKASPENMSAILQSVNGLRFYRISDISNRAKGLLSRWTKLFAKIQAMKKQNRNSSQIDSQSQLLLKQSIAEIMGDSSNPEDILSLSNGKSENVRRIESSQGPKLLLTSADDSTKKHMLGSNPSYNKERRKVQMVEQPGQKAAGKSPQTVRIGTSGRSRPMSADDIQKAKMRALYMQSKNSKKDPLPSAIGDSKIVAPEKPLALHSAKDSPPIQNNEAKTEDTPVLSTVQPVNGFSTIQPVNGPSAVQPVNGPLAVQPVNGPSALQPVNGPSAVIVPVQADEIKKPSTPPKSISSKVGVMMKMSSQTILKNCKRKQIDWHVPPGMELDELWRVAAGGNSKEADVQRNRNRRERETTYQSLQTIPLNPKEPWDREMDYDDSLTPEIPSQQPPEESLTEPQDSLDERRIAAGAATTSSSLSSPEPDLELLAALLKNPDLVYALTSGKPSNLAGQDMVKLLDVIKTGAPNSSSSSNKQVEERVEVSLPSPTPSTNPGMSGWGQEGIRNPFSRQNQVGTAVARSGTQLRVGSMQWHQTNEQSIPRHAPSAYSNSITLAHTEREQQQYMQPKLHHNLHFQQQQQQPISTTSYAVREPVGQMGTGTSSSWRSQQSQNSYYSHQENEIASASQVTSYQGNSQYMSSNPGYESWSPDNSPSRNQLNMRGQQQQASRKHDSSTHPYWNQNKRWR
The following text describes a protein:
Function:
Histone-binding protein. Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation. Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus.
Sequence:
MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDPSKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEILSSEKQLIKMEKKEEEDNGERPRKKKEKEKEKEKEKEKEREDKEKATVSDNVAASAASTTPATSPPGVNTSPSVPTTTTTAEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQKEGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINARLQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNLNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKTSILPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAGSSDMEADMAMETLPDGTKRSRRQIKEPVKFVPQDMPPEPKKIPIRNTRTRGRKRSFIPEEEKHEERIPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVRMRLSETKNRCDECRLCYHFGCLDPPLKKSPKQTGYGWICQECDSSSSKEDENEAERKNISQELSMEQKNPKK
The following text describes a protein:
Function:
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
Sequence:
MFRQSKRRVAQRRHGDGADGATILAGLTAEEEQARYDQLYPAKLSFYALPPVGEITLDQFETWAIDRLKVLLELESLIQRNRAGRELEQAMKPLLGKLLPLGEEQEARRKDYYSHFILRLCFCRTAELRERFVRAETALFRLRFQMLTSADQARFVQSLDLPLVQFIDEAEKQALGAQLYDAVAPQLLHQLQLTDEAQRRQFFQHERFLKLPFESVIDLVGPRHVLLRGGWAYLPQFMQLNHIAAEYAARLATDLRATYQHLPALAGDDRLPPILAHLSAGHVVAPPPPPTGGGLTAADLAAEPVRAALPLCARGLLDGLAANHHLRYLGRQQLALFLKGAGMSADDALRFWADAFTAGPTSLDRFNREYRYALRHTYGLEGNRINYRPWDCRTILAKPRPARNEFHGCPYRDWAPDRLAAALAAMQLAPPAVAAVRDACARREYTLACTHVFDACHGHVAPSAPGHVPAPDMSHIVHPNQFFERARPA
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Fta2, fta3 and fta4 associate with the central core (cnt) and inner repeat (inr) region of the centromere.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MDIYEHKKSFMERQIRLLNRPMRPPKDWKLPLKSGQLSESVVETVFQRLQLRIQKHAKLNYSHQATQHVAAQIRKLYEQNSAIEDITFLNPLFYGEIDLSNLDSVKSLPHPWPFQKESRPVEKDEEQEKFNRLTGELLGLLTTLSELEQERSELEQIEKMLEPFEDGPSSIHTNMWKKNPELISTLNSTNTMVAKINSLLRGVSFPSLNNDNQEASLEDEIRSQLFEKTISDD
The following text describes a protein:
Function:
Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MSNFYDGDNRRGGYSGGGGGGYGGGGGGYNDRRGGGGGGGRPPSAPFPTEPPFTAFVGNLPDDTVQGDLDHIFAEMQIQSTRLVHDKETGKFKGFSYVEFEDTQSLKDALKLNGAIYDDRQLKVDIAQGRNKGQRGGYSGGRGGGRGGYDRGGRDGGYSRGGGGGGYDNSRGGGSWGDDRRGGGGGRDEGYRGGGGGGSGGYGGGRDGGYGGGRDGYDNRDGGYRGGGGGGRGRGTGRDDYSSSRPTQEFREPTAEESAARPKLKLAPRTVKEPVGGPPSRRSDIFGTGKPREEKGGSDKKPDEASS
The following text describes a protein:
Function:
Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons. NRTN-binding leads to autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MTARAAPFYARGFLSRNRNMYIYIGFLLFLDELVFSMSGSSSLSESGNQDSMDCLKATEKCNQDQKCSHRFRIMRQCLAGKDRNTMLANRDCQVALEVLQEMALFDCRCKRGMKKEMQCLQSYWSINIGLTEGEDFYEPSPYEPMTPHRHSDAFRLASIISGMHSGTSKGQPHCTDPSRPCNPCLDATKACNLNENCKRQRSNYISTCTRAQTQGQQPSQTQTQEGCNRKRCHKALRQFFERVDTQYSYGLLFCACKDQACAERRRQTIVPSCSYQDKNKPNCLQLRNTCRLDVHCRSRLADFHTNCQMTPHSISSCLNDDYQACLASYTRLIGTDMTPNYLDSGHSNFTISPWCTCKGSGNLEEECEKFLQDFRENTCLRNAIQAFGYGSLPKPDPQPTTGSVKPDLEPTATVAKTTMEPGEDPCIISPCSNLNELDCYPSKDYNCESAEMKLSKPESPLNTRVEDPRNTSPGVKALTEAMMQSLLFALVTLVM
The following text describes a protein:
Function:
Probable transcriptional regulator that is required in neural development for the normal formation of sublateral cholinergic motor neuron processes. Plays a role in regulating the expression of acetylcholine transporter protein unc-17 in the sublateral processes. In particular, it is required in sublateral motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis.
Subcellular Localization:
Nucleus.
Sequence:
MSEKETPSPVLDVKKEKNEETGIDEEKSSEDDCSKRSKVKSNPSKFSVNSILSPLESLVRVQQQLLKMAASKSGTPGTNAGVPGAFPYGPGRLPGNYFAGPFPGYSGAQPNWYNGNDPRFAAAAALLPCSIDPVRSAINHQFSMSSMSQRRKRRVLFSQAQVYELERRFKQAKYLTAPEREQLANSIRLTPTQVKIWFQNHRYKCKRQEKEKAMSGLGHSEDGSSPPPDNDDDDDKYSIEMDDKDDEEEEESEKPVLKPSGVFGLPYPPNAAAAAAAAAAAFNFPFAAQGPNPAYYMRW
The following text describes a protein:
Function:
Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.
Subcellular Localization:
Nucleus.
Sequence:
MEIDAPNLNDALQEASTEEKLTSLKDSISQNPYNYQSHLDYVQLLRGHHDKQNELEAARRNFQQHFPLSEYIWMDWLNDKLQSCNGVEDYIDTDKLFSLAVKDYLSTTIWSSYMQFKIETNALALEENNTDLLQVFSTKQVCDVVKLAEQTTRFHFTESHVIWDIYITFMRERGFSALYPSVSIDELSLQCYLKRLEIPHEKIESTFATFSTFVTQSFPNDYESIMINANRVFSNTLKKSNAISRQELLLRSSGYPLEEFESFVNSEMRKPKQIAGYVVTLLERLLSIYPLSTDGWCLYVSWIIKETREDESANINLLNVCERAIRNCPWTAKFWIFLWYAMLLYSTDVSEIEKSKELAFSTGLITDHGEIVELLCGWLQISVYICAEKENSEDYIRSQINYAKKFIATTLSKGKHDFFKLDLSIIALHTAVSNVDAALKLWSHMEKVYPHKSQFWIQRFEWLYPRDKKLALDTLTRGLSKKLDNPKELMEYYDLVLVKNYDLFSALEQEYDLFHAKRLFQQRLLREAVSGTKEHSLESTVQIATPETTQLRPKLKRNIVDEESAMPKKIRFAAKQRNREELTILVTNIPTSASPDDIRSLFSDCGTINELVVLPDDDGQTKVAQVEFAEPGEVLAAKTKHLKKIHGHEINVRDHADTTLFVTNFPPSFDEQAITALFEPFGAVVQVRFPSLKFNARRRFCYVQMRTPEEAHNTLQLNGKLLEGNFELKVHLSDPDNKQSREGPIYEKRELYVTNIDFACTKTDVEKFFSRYGSVENVRLPSRNPYRHAGFGYVVMSNKDEAERALSATGERLGSRVLNVVISVAKPPKKVINSSKPPVSTKPSGTELPRVTLEQVHNKSLGVMNVDETVNEARLRQMFEPYGELFRVVLHPEHNGAIVEYKDPAKAGKAAMSVEGYELAGRRLHIGSVDEMMHAKLTDTSENPSTKSSALEFVPNIRTLRRGHRLGNFKAAVQESTNDDMDTDAPKSNDDFRRMFLNN