lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer.
Subcellular Localization:
Nucleus.
Sequence:
MSGMGENTSDPSRAETRKRKECPDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHNEFVKNLLPKSIVNGGSWAGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYEAMQCFAVSQPKSIKEEGEDLQSCLICVARRVPMKERPVLTSSESFTTRQDLQGKITSLDTSSMRAAMKPGWEDLVRRCIQKFHAQHEGESVSHAKRHHHEVLRQGLAISQIYRFSLSDGTVVSAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQAMGKPLNPISSSSPAHQPMCSGNPGQDMTLGSNINFPINGPKEQMGMPLGRFGGSGGMNHVSSMQAATPQGSNYALKMNSPSQSSPGMNPGQPNSMLSPRHRMSPGVAGSPRVPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAESSCHPGEQKETSDSSLPQAGSGERADGPNRLHDSKGQTKLLQLLTTKSDQMEPSPLASSLSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELSQDTNSTAPGSEVTIKQEPVSPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDAASNTKLIAMKTEKEEMSFEPSDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGSNSARPTMPSGEWAPQSSAVRVTCAATTSAMNRPIQGGMIRNPTASIPMRPNSQPGQRQMLQSQVMNIGPSELEMNMGGPQYSQQQAPPNQTAPWPDSILPIDQASFASQNRQPFASSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQAQMAQGGYTPMQDPNFHAMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQLQHRLQAQQNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRHMHQQQQVQQRTLMMRGQGLNMTSSMVAPSGIPATLSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATAPQSPLLSPRMAHTQSPMMQQSQANPAYQASSDMNGWAQGNMGGNSMFSQQSPPHFGQQANTSMYNNNMNINVSMATNAGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDASRKYC
The following text describes a protein:
Function:
Essential for chloroplast development, especially for thylakoid formation. Involved in plastid gene expression, probably by maintaining plastid-encoded RNA polymerase (PEP) activity.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASFTCSSPSSILPIIDTRSGNLRCTFQSQVSCGIQRDDNGRRVWRRRTLTKKDDMLRYKMQRVPFVEEQVRKIREVGKVMTMDIEQLLLREDNRFEFVNSVAAEATEYVDKNRDEYGGSKKAIFHVLSNRVNDLGFDRPEAYVEADPYKPGPGYLLEYYT
The following text describes a protein:
Function:
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
Subcellular Localization:
Cytoplasm.
Domain:
The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.
Sequence:
MRASIWGTGSYLPKKILTNADLEKIVETSDEWISTRTGIKERRIASAEEFSSFMGAKAAEKAIEAAKISKSQVDCIVFSTAAPDYIFPSSAALAQAYLGIKEIPAFDCLAACTGFLYGLSIAKAYVESGMYQCVLVIAADKLSSFVNYQDRNTCVLFGDGGSACIVGHSRPGALEISKVNLGADGKQGDLLRLPAGGSRCPASQDTVQNHQHFITMEGKEVFKHAVRRMEFAAKTCITEAGLQEKDIDWLVPHQANERIIDAIAKRFAVKDSRVFKTLAKYGNTAASSVGIALDELLRTHDIHVAERLLLVAFGGGLSWGAVILQQV
The following text describes a protein:
Function:
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Secreted.
Sequence:
SHTASGFLSPAPPPAPFPLPLPLPSPIRPPAPPPPIPRVPGWGGGEAGTAPRPHGRPSEPEAEGAPGGAGHRPAGPARAGPGPGAGLPRPPAGRGQPGEPGIAVRPGEAPLRTPSWAHQELRLQRGRWGPGGLKASGREDGWRARCQVERHRVTLPPSQQEPAQEELVAEEDQDPSELNPQAEESRDPVPFLNRLVRPRRSAPKGRKTRARRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYCQVHFDEGKAVYLKLDLLVDGVLALRCLEEFSATAASSLGPQLRLCQVSGLLALRPGSSLRIRTLPWAHLKAAPFLTYFGLFQVH
The following text describes a protein:
Function:
Transcription repressor that binds specific DNA sequence such as GT3 box 5'-GGTAAA-3' in the SDD1 promoter. Negative regulator of water use efficiency (WUE) via the promotion of stomatal density and distribution by the transcription repression of SDD1. Regulates the expression of several cell cycle genes and endoreduplication, especially in trichomes where it prevents ploidy-dependent plant cell growth. Regulates negatively root hair growth by directly binding RSL4 promoter and repressing RSL4 expression.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing GTL1 fail to develop root hairs.
Subcellular Localization:
Nucleus. Note=Present within the nucleus during the postbranching stages of trichome development.
Sequence:
MEQGGGGGGNEVVEEASPISSRPPANNLEELMRFSAAADDGGLGGGGGGGGGGSASSSSGNRWPREETLALLRIRSDMDSTFRDATLKAPLWEHVSRKLLELGYKRSSKKCKEKFENVQKYYKRTKETRGGRHDGKAYKFFSQLEALNTTPPSSSLDVTPLSVANPILMPSSSSSPFPVFSQPQPQTQTQPPQTHNVSFTPTPPPLPLPSMGPIFTGVTFSSHSSSTASGMGSDDDDDDMDVDQANIAGSSSRKRKRGNRGGGGKMMELFEGLVRQVMQKQAAMQRSFLEALEKREQERLDREEAWKRQEMARLAREHEVMSQERAASASRDAAIISLIQKITGHTIQLPPSLSSQPPPPYQPPPAVTKRVAEPPLSTAQSQSQQPIMAIPQQQILPPPPPSHPHAHQPEQKQQQQPQQEMVMSSEQSSLPSSSRWPKAEILALINLRSGMEPRYQDNVPKGLLWEEISTSMKRMGYNRNAKRCKEKWENINKYYKKVKESNKKRPQDAKTCPYFHRLDLLYRNKVLGSGGGSSTSGLPQDQKQSPVTAMKPPQEGLVNVQQTHGSASTEEEEPIEESPQGTEKKTL
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MGQPEGLERFDSPGKGRGLKATRSFALGELLFTCPAYTYVLTDTERGNHCDFCFARKEGLSKCGKCKQAFYCNVDCQKGDWPMHKLECSAMCSYGQNWCPSETVRLTARILAKQKTQTERTPSETFLSVKEFESHLSKLDNEKKELIESDIAALHRFYSKNLHYTDNAALVFLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNIIVTFKGTVAEIRAVQEIHAGDEVFTSYIDLLYPTEDRNDRLMDSYFFTCDCRECSTKQKDPAKLEIRKLSDPPSHQTVKDMIKYARNIVEEFRRAKHYKTPSELLEMCELSLDKMGSVFVDSNVYMLHMMYQAMGVCLYLQEWDGALKYGEKIIKPYSKHYPAYSLNVASMWLKLGRLYMGLEKTTIGTKALKKALAIMQIAHGPDHHYIAEIKKELEL
The following text describes a protein:
Function:
Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.
Sequence:
MTYGEILAHIYGLRRFGIRPGLERIATLLQRLGNPQERLRVVHVAGTNGKGSTAAFLASILAEGGYRAGLFTSPHLTRFTERFRINGTEIAEEAAARVAGQVLASAPEGTTFFEVVTAMALLHFVEEGVDAAILEAGMGGGADATSAATGILTVIAPVALDHCEWLGETIPAIAREKAGLIRAGRPVVLSRQPAEARDVFIERGRILGAPLVCFGADFSAAWDESSLAYDGLSRQLAGLRPGIGGRYQLANAATALAAAEILADNGFRLDSPALRAGIDAARWPGRMELFSGAPRVLLDGAHNPDGARALAESLADYPRRRLIVVTGVMADKDAAGILAPVLPLAHEVVAVTPAVERGLDAGRLAELCREKGLNAVAGGTVAEGLALARQRAGEQDLILVCGSLFTVGEARAILLSQQYEPFRG
The following text describes a protein:
Function:
Antimicrobial peptide that binds cell wall carbohydrates of microbial symbionts and induces structural damage. Binds the cell wall carbohydrates mannan, N-acetyl-D-glucosamine and lipopolysaccharide. Can target fungi, Gram-negative and Gram-positive bacteria.
Subcellular Localization:
Secreted.
Sequence:
MKSLLILFAIVAVVAAFPELERERRGVIAAPALAAVPLAPTIALAAPKVAPAIALAPAPKLLAAPAVVAAPGPWKAW
The following text describes a protein:
Function:
Involved in mRNA transport from nucleus to cytoplasm.
Miscellaneous:
MISCELLANEOUS: Present with 6340 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDNLQVSDIETALQCISSTASQDDKNKALQFLEQFQRSTVAWSICNEILSKEDPTNALLELNIFAAQTLRNKVTYDLSQLENNLPQFKDSLLTLLLSHNQKLIITQLNVALARLAIQFLEWQNPIFEIISLLNSSPSILLNFLRILPEETLDIASTSLTEVEFNSRIHELIDPIAEDVLKFLVSCIDLLQNTDGNSSSSISLEQILRCLNSWSYEFPVEQLLTVQPLINLVFETISNGNESDMEAFDSAIDCLCVILRESRDTTNEQLISALFHQLMLLQEKLLPTLFTDHPLNDEYDDDLLEGMTRLFVEAGEAWSVVISKNPDFFKPMVLVLLMLTCKNEDLDVVSYTFPFWFNFKQSLVLPRYQESRKAYSDIFVKLINGIITHLQYPSGQFSSKEEEDKFKDFRYHMGDVLKDCTAVVGTSEALSQPLIRIKSAIENNNSWQIMEAPLFSLRTMAKEISLTENTILPEIIKIICNLPEQAKIRYASTLVLGRYTEWTAKHPELLEVQLQYIFNGFQLHEGSSDMQSIITASSHALMFFCSDCSKLLVGYIDQLINFFLNVQSSIDIESQFELCQGLSAVINNQPEAKVSVIFQKLVDDNLRQIEALIPQWKANPTLLAPQIADKIDLLYALFEELKPRYNYPQQGSEPLLPRIEFIWKALRTLLVDAGAMTDSIIVERVAKLLRRIFERFHVFCEPILPSVAEFLIQGYLTTGFGSYLWCSGSLIVIFGDDESFPISPSLKDAVWKFALSQCETFILNFNKFDKLQLNDYHEAIIDFFSLISDLIMFYPGAFLNSTELLGPVLNVALECVNKLDNYDAYICILRCLDDIISWGFKTPPISTVSIEIVPDEWRKQVINEVVIAHGNQLILVLFIGLVTTFENTAHSDAISCIVKCLRILTEANNNDATICIDWIYKVVEQLGQVTLNERDNLAKAVVEGLNSKDYRKVREGIRAFVGWYSRKNINSRFE
The following text describes a protein:
Function:
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
Subcellular Localization:
Cytoplasm.
Sequence:
MINHNIISFKKFEAIFEQRPGGLELNMPIEIGSNNVDLTSKPFNIKGGSHYKVKIGYMASEPITDLICQIHTFRKSTPYGRDTQKVGDICANTNDLEFDFPKFGWEQASTQSSSMGDYTIKMYFKGNGNQDLATFFYSFNVAPDWENALPIN
The following text describes a protein:
Function:
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Sequence:
MEFRFNMHPLFRARIVRINNSLLPTGFVAQSRRVALDATAQISEIINTIGSMSAQAQGLSVPVTTAQKLRNSDHHIYLMFESNDRNGLVVGILKVGRKSLYVFDPSGETVNVTAPCVLDFYVHESRQRGGLGRELFEHMLREENIQPDELAIDRPSEKLLGFLQKHYGLSKKIPQMNNFVVYEGFFASKAQNSTDIDGRRMHITASPNTNLFGPTFTTTEERRRSTSQTRTNVAPMPIIAQPPVGRYAAKRPTCSMAQVNHYSSMVGKISFPEENTGNGKRSVFEEQELDQRLADEMERCVELGAGGDEPDASRYTPHHGLEVKFADQPETLPYDDMPEPGPDPDPYDFHPHHLELHDDTEGGGSHRDQSLSPQSVSQQASPVHPAGSDYGVLGSRKPARYTKQNTGLKNISFGVGAAVMPSGKMEFDQEENEGFGSVKINRPIGKSGTRGSLHDDNESVHSNGSQQGGGGHFDLKFYHNKLW
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MALSGFASVQNPMDPRKWTSGTLLEYLQLHEIFTGMEWESHTVGKEERLLLVRAVRDDLDRFYHMGGDASGLVPLENVLETDPKILLRCRVPPGAATLLRQYPQKLGDTVNAGLEMLMEERTKYSSPAAWKCTSNALPMVEWWLGLTVDEEGEKMIREETGFRVCGRSFQPGEILVFCKDCASDCSCVMCSDCFKSSPCINHNYVVRQCLIGGGMCDCGDPSAWKTASFCTRHRGFQSSADPAADMDCTKRQWLEVLSRGLVLYITTIVGAQAEYQCNSNSSDDQLARMQWFDRALRRIADIALLLSASGDGPRRVLCHSLMEKALVSRRVECVADGKRLEEMRHLSCMEELFLYGFEIPKLSRFSIWERSILWLFNNTLCDPLIRVPFAELLLKYGERGATRRELHVATLSVQVFTSSDVVDSLLLREPHPKWESVLKGETILHRLISCLLYCSCETMNVRNASPQEVSRAVRCCRWMTEVLCVTQNTCAIVVSRQLYRGWCRLLTINGSASMVFRRTSVGESDGGSVETDCAMNIELELQQMFHRIANMARDVAVSLHAGELLIPPRLLESLSSSSWCGALDPAVESSKRRDMLEGFSVQGGSALLVGGGGVGCNVTCREYMRELMRECMVAINALLQEKRGGFSPKEVISVDADGKPLLERYDLLDKKSPNPTSFVLPHMRFFAEIVKSWMKVQKRIEESGAEVEQGSFVSLLSELFAETEARADYWIDELLMPLVLLCQHEQGLWHGERFELSRRCECYVACSTLMIEADVCMMQLLMLLVPTETFAAQLLNRFMFSKENRALGYTGFLRLVLTLCVQDCSLLINNKADLVFALKRRLLHVIAGDRGHSLDDLERVASELEHALPGINLDELLPLIFREVTTTVKSRKRAVVQFKDVCTWRSYINLYHPSLRDHHLPDMCDLYDRLVRRKRMGTDSGGEGDSNDAPAVFPPPNIRWVEVTERPEEGSWEARRAAVFRDKVFLLLQDPCVLSVAIRAVHGYMFDGLEGCSGSEGTVSIITLAHAISLLYLAMRACTIIGAGASGGSAATVVDWDAVGKFHKKNSSPPIHAPQQLNQLLGVEGLLNARNLKEALEVPVEADLVFGAGRSPVSTASATTTVDALRKLRTRFREVTKDIFGIVGMVEFILQGMSEPSLSVGADKPAVGESQRGEGECCRPDVKGKQSALLKRMKAINAKKSFAMLSDPSRFGFYATQDAPAPGVKPSVCEGGSHSSVANPILQRIRSMDCCICRDHARGSLALFGNVSVSDVLDRLRFDDTGVDSHQQQPQKRKLSTHFYLCGHAAHMSCVKRIFGRMASTLQNTPDMDRLPAAVTRNDFSCPMCLMVCTTLCPCPVPPANVATGEASSLFEMVRESSLRAVSSDEAARGALQSLWCDISSVAVTNSSCDGSGNESRSVRKQPRDENKNIREVVEVARSVRAQMCVALEWVKVGGAVLYNELLTLLSLMISLEPILLEGTISHACAELSCHDVDDNFCVLILNALLHPSDAAEYVAQYTTLLLHSSDCSALTSGPVDDDGQGAHSGLLMSVWRELGCLTLLKALLTDNTPSEVVQIGDDKVVFIPFQSEELATLEGQSQAVFTMLCYLLQKPLQNCEWGHTKASEALVSLIHKAVSEGNEKMIKGTPLSLLHRCRDVSLLDDAPRFKPLGVVYEGALLWKRFLMNRVLHLPDAHAQLLLSLNPNEPCSMCGDTEGNRLLCCFCGKLFCLRPSQRPPELYIHALSCGSGLGVYMSPEDNRIYVLETRRSQVVVLAGPYADEYGRPAVRGYTSRQLTLNDDLAHFLLSLWIRSRWNVEFTVVSEMKRRDLRLL
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MAVLILALLSLSLGSYQIKDLIRTYTIGDSTEVVEQATLQVKLVKSEPDEAFIYGLNAALMERIGLIKAFYGKDTSGPLLSVDLFNEGYNKTGIKVHLINGRSDGWTGAIPEDFYLHIYIVYPIGGEILNVVSTPTLSEEVLSTLRDNNDVNQMHHLATLKFTTCVELPSFYPCSKQKTSFNFNSRKTKFSSLDTDFRGYRVSTTETTTQISIDQIAYGPEHTCTLIDMTYYSNAYQFAVSAVRTVIINGPNIKTKTTMSGFVTITDDFVIRNINPRSSDKHFSNKNILMRQHYDMTIPAFFVIELPCEVELDDISYYDRIGKIDTIEIDTESMRKLRQRFGEQTRTLLKVKPRFAVAGDSQTKFTLKYKCNNLVSLDKSSAEALPKRLERDTYGLVLPSGPKILHAYYDSFSLCIYPPSGATNVQVHVPFTGAISNTTYSGALDIHPRNGGCVSTGLSTNEGISTPFTTIWGYDTKEMLWKKLRPLSINLFAIMCTLSFLRTMVGK
The following text describes a protein:
Function:
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Confers sensitivity to the virulent bacterial pathogen P.syringae (By similarity). Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription. Involved in embryogenesis regulation by auxin.
Subcellular Localization:
Nucleus.
Domain:
The F-box is necessary for the interaction with SKP1.
Sequence:
MNYFPDEVIEHVFDFVTSHKDRNAISLVCKSWYKIERYSRQKVFIGNCYAINPERLLRRFPCLKSLTLKGKPHFADFNLVPHEWGGFVLPWIEALARSRVGLEELRLKRMVVTDESLELLSRSFVNFKSLVLVSCEGFTTDGLASIAANCRHLRDLDLQENEIDDHRGQWLSCFPDTCTTLVTLNFACLEGETNLVALERLVARSPNLKSLKLNRAVPLDALARLMACAPQIVDLGVGSYENDPDSESYLKLMAVIKKCTSLRSLSGFLEAAPHCLSAFHPICHNLTSLNLSYAAEIHGSHLIKLIQHCKKLQRLWILDSIGDKGLEVVASTCKELQELRVFPSDLLGGGNTAVTEEGLVAISAGCPKLHSILYFCQQMTNAALVTVAKNCPNFIRFRLCILEPNKPDHVTSQPLDEGFGAIVKACKSLRRLSLSGLLTDQVFLYIGMYANQLEMLSIAFAGDTDKGMLYVLNGCKKMKKLEIRDSPFGDTALLADVSKYETMRSLWMSSCEVTLSGCKRLAEKAPWLNVEIINENDNNRMEENGHEGRQKVDKLYLYRTVVGTRMDAPPFVWIL
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MGSKLKFELERFLSENPIVACENVFAEESVQKGVPSMGADSCSGLSLEKLHSNGSLENGPVLINEFQQSSTGQFRTGESNRIGDRSLTSAVEKLSLGGEGTGQTWMNHPNLMDDQFESYMNKQSINSEASTVANPSLRSSNRVSNGYYEIPVPGLSPQLSFSARLVSDVQKKGDAAHLTPFETPNSAMPFTHEVPARNLQFSLPSHHDQMLLNGLSPVHFMHPQQMNHGEIGPNSVKGEQLHSCRMQWQQQYLHDLHNQQLERSNLFESCGNAAFGSLRFQSPKQQRFVEVPFHPCREQSKHEGFCNGAAHCAASGIPNHAFATPFLDTLDAQEKCFKQSSPRKIPTRAHGLIGVDTEKLKYYFSQNGFLCPSCYVRQYGFPSTAKDCICHDNFRVSSMLSSHANRKTEIPPLKCNSLDEATGKIYLMAKDQHGCRFLQRMFSEGTKEDIEMIFGEIIHHVSELMVDPFGNYLIQKLLGVCDEDQRLQILYKINRPGELIRISCNMHGTRAVQKLIETLKTPEQFSLIVSLLKTGIVILMKNVNGNHVAQHCLQYLMPDYIGFLFDAATKSCVEVATDRHGCCVLQKCLAVSDARHRDRLLSEVVRNALVLSQDQYGNYVVQFALELARCPSILPWVTSGIFKRLEGHFSDLSIQKYSSNVVERCVYAGDEYLAKVVDELINDERFSQIMLNPYGNYAVQAVLARSGICKSSVHAKLVAAIRPHVPLLRTNMYGKKVLAVLAKTN
The following text describes a protein:
Function:
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Sequence:
MILKDLLIEGYGVLKKASIGSYQIDAQLLLGKVLKKDRLFILTNPDYHIKEEEKEKYFQLIDLRKNKMPIKYILGTTEFMGLNFNIKKGVLIPRPDTEILVETVLEEIKNKNYKQICDVCCGSGIIGITIGYTLNNTEIICYDIEDIPYNTTKENILKHNLQDRVKALKSDLLTEAIKEKRRFDLIVSNPPYIREDVIETLMDDVKKYEPFEALCGGKDGLFFYEGIIKQSLEVLNDGGTIAFEIGYDQKIQVSHILNEYGFKDVLCIKDLAGKDRVIKARKY
The following text describes a protein:
Function:
Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing.
Subcellular Localization:
Cell projection, kinocilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus.
Sequence:
MGALPHENKAQVNSESNRLYFATLRNRPKSTVNTHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKKLKSYSLSRKKIVHYTCFDQQKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKSRPSNEGSLNKILSSLDDMSIGGNLSKIQNVERFGENNLEEDEDVEMKNNITQGDKLRALKSQRQPRSSPPCAFRLGDMKGHPRAASQPSRLSSSPQGSASTLKTSKVALSPSVTAKRINRGSLSSGAAAVRSFSINSRLASSLGNLNAAAAEDADNKKPAAASKVGFVASPFSNLLNGSSQPPGRNYPELNNNQYSRSGGSSGSPLGGPPSPPGAKADAHSPALRPAYTGLSSSSARFLSRSIPVSSQTPPLGPQNPERNYCALPSQPRLPPKKVNSAKDAF
The following text describes a protein:
Function:
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
Subcellular Localization:
Cytoplasm.
Sequence:
MAQTVDAIVTQRVARFRDRCKPPIAEDIYDEIILLMEEKMESGKVASLLTVSEKARKYWRTHGREFVDLVELQEQLGRPAKGILLTNGRALLSDSLAEEVILKYVSEHGKDCPQSIQKDMQSLFELPLPLIQHHVKRSINVKVGKDRRYIRQKFEERMNEVRNQTIAEAREKGDAAASLPVLLIRPTPKRKAKPKSHAQKLRDQETRTAYQLPPTLANWQEHPRNLIPELCRQFYHLGWVTGTGGGMSIRLGQEIYVAPSGVQKERIQPEDLFVQDLEERFLAGPPPHKKLRKSECTPLFMNAYTLRGAGAVIHTHSKAAVLATLLCPGPEFRITHQEMIKGIKKGQSGVSYRYDEELVVPIIENVPFERDLKASMKEAMERYPDTCAVLVRRHGVYVWGDTWERAKSMCECYDYLFDVAVKMRQLGMDPAAAPGGACPVGDPGASSTPATPDAALDQEVAPGQPSTLAEAVQVATAAAEAVGLQPVSGLSALAAGDLAARDQGFPVTLDANMATEGQTTYVVYM
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MQRFSLVTHRSFSHSCVKPKSACSLVKPVHHLVKIDKSKLSPRFPELKYDKSDIRSPGFKPKDTHADRLNDHYLNTLQSDLLLINYSHNAAVVKGLKQRAWSGDSPYHLNRPPKNPRGSKAQLPDIHPIKWSNIPGLESVVINCFVREARENQLLAITAALQLQQITGCKPHPIFSKNDVPTWKLRKGHQMGAKVELKGKEMSQFLSTLTEIVLPRIREYKGISNQSGNRFGGISFGLTAEDIKFFPEIDANQDSWPKTFGMHININTSAQLDYQARTLLSGFQFPFFGEEK
The following text describes a protein:
Function:
Plays an essential role in viral protein synthesis. Plays also a role in active nuclear export of mature particles before host cell lysis, by interacting with host XPO1.
Miscellaneous:
MISCELLANEOUS: [Isoform NS2Y]: Splicing isoform (approximately 15% of the molecules); MISCELLANEOUS: [Isoform NS2P]: Major splicing isoform (approximately 85% of the molecules); MISCELLANEOUS: [Isoform NS2L]: Minor splicing isoform.
Subcellular Localization:
Host nucleus.
Sequence:
MAGNAYSDEVLGATNWLKEKSNQEVFSFVFKNENVQLNGKDIGWNSYKKELQEDELKSLQRGAETTWDQSEDMEWETTVDEMTKKFGTLTIHDTEKYASQPELCTNSTCIGSRGPGFRALEHTKYSCCGHCRNPEHWGSWFQSLPRWSTEPNLVRDRGGFESVLRCGTVEERLQRAAELGLRYDGASS
The following text describes a protein:
Function:
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.
Sequence:
MVGIISSGVCRVSVTATTLLFREFVRKAKVRGTALNFSLASAATVGGGGGIRRKLERVAGSAGLIMGSSGSVLPRSLVWNSKRDKSSTGETDQHQTPLTMEKKEELVAKLTPLQYHVTQEAGTERPFTGKYNKFYEKGTYICVVCSQELFSSETKYDSGCGWPAFNDVLDQGKVTLHKDPSIPGRVRTEVRCSKCAAHMGHVFEDGPPPTRKRYCINSASIEFMPAGSERKDGTS
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MLPTPRRVKNKAPAPVQLTAEHLIREARELHGDGSVTVCLPAESKKRRIVDADELAEHRLERRARFEAIVRRAGSGRGGCGDASSEWMRYARWEESPGGGGGDPARARSVYERALAGGAPAYRDHGVWIKYAQFEARGGRVGHARNVLDRAVAILPRADRIWSEYLRMEDLLGATDNARVVFDRWTSWRPGADAWAAYAAFELRHGELDRARAVHERHVAALPCADAFILFAEFETKLKNLDRAPRVYEHAGSLLAAAGDNDDTAVLLAAFADFEERCGEPDRARAIYQHALRGEPPEPRAEELREKLLSLEKRFGDRHGVEDSIVTKRRSQYERAVTTNPLCYDAWFDLIRLEESANTGDANRIRDLYRRAVANVPPAAAAAEKRHWRRYIYLWINYALFEELDAEDVARARGVYRECLRTIPHKKFSFSNICVMAAELEIRDKNLAAARRLLGNAIGVAPRPKLSRRYIEIELQLGNVGRCRILSQKFIEHAPSSSHVWRSYAALEKKLGETDRARSVYDLAVSQPALDAPELVWTDYIQFEIDAGELDRARQLYERLLGKTQHLNVWVSYAEFEATACSGGAAIAGNAAEKAERVRRCRAVCRRADEHFRGCADDPAMKEARAMLLQQWLAKEAAFGDLGEVEPVEKKTPRRVKRKRSLLADGNGGGGGCEEFFDYIFGDEEDATAAAGFKLMKAAYEWKNSGHVITY
The following text describes a protein:
Function:
Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNNRRHPENPSCVITCAYYDGHGARHDISLEQISDELQRPDGFVWVGLYEPQESVLRKLQEEFGLHDLAIEDALKAHQRPKAESYGNSLFVVVNTAQLVNERIRYGETHAFLGARFLLTVRHGASLSYTPVRHRVEREPAMLRMGSAFCLYGVLDFVVDNYLPIMDEFRDTLEGLEKDIFAENYKRETVVRLYELKRELNKMRLVVAPLQDVLSHLKRNPGSLIHGEVGVYLRDVLDHAVRINDAIDTLREMLGTALSVNLSMVTLAQGETVKRLGAWAALLAAPTLITSWYGMNFTHMPELDKPYAYPLLVGGIVASCLVLYRLFKRARWL
The following text describes a protein:
Function:
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MDIFRILSRGASLNKKKGITTDYALPSEKQTQKQKHKQESLLNEVERETDFFHTRKHNSNSTTTSGKGDKLTNGANSNKEEQMETNETKAKEEEIPPPELTTEEDAQTFRNLHKSKVTGDDIPIPIGSFQDMIGRFHINKKVLSNLIDNEFVEPTPIQCESIPITLNNRDLIACAPTGSGKTLAFLIPLVQQILSKNVSKNHGIRGLIISPTNELAVQIFQELEIITRGCKQINVAILSKQLASKLNNNIIKSSKYDIIVSTPLRLIDVVKQGNMDLSKIEQLIIDEADKLFDHGFAEQTDEILTHCTNPKIRKSIFSATIPSSVEEMAHSIMKDPLRIIIGHKEAASNTIDQKLVFTGNEQGKLLAIRQMIQQGEFKPPIIIFLQSITRAKALFHELLYDRLNVDVIHAERTPKQREEVIKRFKNGDIWVLITTDVLARGVDFKGVNLVINYDVPQSAQAYVHRIGRTGRGGKAGKAVTFFTKEDDKAIKPILNVMKQSGCNDGYSQWMEDMGKLSKKEKKQIKTHEIQRKKISTVPKVIKQKRKQRQDMIAASKRRKQESKQESKQESHSNDEREE