lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May act as a negative factor in protein storage vacuole (PSV) trafficking regulation and plant effector triggered immunity (ETI). Negatively regulated upon interaction with GSF12, and also probably by BCHB. Required for ETI, but not for cell death.
Domain:
The BEACH-type PH domain (1556-1653) is required for interaction with GFS12.
Sequence:
MNGKESRGPACSFEFVGESSGLLGPGESRWPFTNGYAFATWIYIESFADTLDASTAAAAIAAASAAKSGKISNAAPANVHTGEGTAHMPRLFSFLTPDNQGIEAYFYAQFLVVESGSGKGSKTSLHFTHAFKPQCWYFIGLEHTCNQGLLGNSDSELRLYIDGSLYETRPFDYPRISKPLSFCCIGSNPPSTTAGLQRRRRQCALFAEMGPVYIFKEPIGPERMTRLATRGGDVLPCFGNGAGLPWLATNDHVRNVAEESSLSDAELGGYIHLLYHPCLLSGRFCPDASLSGAAGDEKTPYSFSAVVFALCYLVFPYFGRPMSLLPLTVSSVHKDNLEPCSRNVPSSLTTYSLAAPIFRMISFAIKHPGNNEELSRTRGPEILATVLGYLLHSLASFDIKHDRVGDEELVAAIVSLCQSQKINHALKVQLFCTLLLDLKIWSVCSYRLQKKLLSSLQDMVFTEATAMRNADAIQVLLDGCRRYFWTIQEKDSVNTFSLDGDARQVGEVNALVDELLVIIELLMGAASPSFAADDLHRLLGFIIESPQPNQVARVLHLMFRLVVQPNAAKAQTFAEAFITSGGIETLLVLIANRVNTMGLETESFQQVKVHGSETVICETGSVTLSSSVNADRISSVSETPFNNNARNNVDDRDRVMVGIIRLIGALISKGHLKFSVGAKSDVMSNLMGSEFRENGGTMFDYKVALLLFALLKAFQAAPNRLMTDNVYTTLLGASVNASSTEDGLNFCDLGHRFEHPQLLLILLRSLPFASKALQNRALQDILFLACTHPEKRSSLTKMEEWPEWILEILISNYEKDAGKQSASPGSAEEEDLIHNFLIIMLEHSMRQKDGWKDIEATIHCAEWLTFVGGSSTGEKRIRREESLPIFKRRLLGGLLDFAASELQAQTQVIAAASAGFAAESLTPKDAKAGVENAALLSVFLVENTVVILMLVEDHLRLQSKQNCAASAVDVSPSPLSLVYPPNYRSHTLPTVGESSEVSSSCASVSSDSGGVHLDILASMADASGQISTAVMERLAAAAAAEPYESVSCAFVSYGSCTRDLADAWKYRSRLWYGVGLPSKTSCFGGGGSGWDSWKHALQKDAQGNWIELPLVKKSVSMLQALLLDESGLGGGLGIGGGSGTGMGGMSGLYQLLDSDQPFLCMLRMVLLSLREEDHGEDSLLMKNLSSEDGITGGLQCPLGNSASVDISSQLSMRQSPSALLWSVLSPVLNMPISDSKRQRVLVTTCVLYSEVWNAVSKDKRPLRKQYLEAILPPFVAILRRWRPLLAGIHELSTGDGVNPLVVDTRALAADALPIEAALSMISPEWAAAFASPPSAMALAMIAAGAAGWEAPAHPAPPAPPPLRRDSSLLERKSTKLQTFSSFQKPLEAPNDDTPGRARDKAAANIDSHLLIQPLTRLTGVFWKLDSMESSSRMRQCLRRNYSGTGHLETTRNYGDQTYLMNNHDSPVLAVEAISKEIMYEDDEHGDADDLEIEGNVGERKGENEERRSGSLEDAITLSTGINDHRPLSEQNMVQNSTEVKDLSELKERIVLEISSTMVRPLGVVKGTFQITTRRINFIVDIREDQHLDEKSDGSKSRDEERDRSWLMSSLHQIYSRRYLLKKSALELFMVDRSNFFFDFGNTEGRRNACRAIVQARPPHLKNIYSATQPEQVSRRTQLMERWARWEISNFEYLMQLNTLAGRSYNDITQYPIFPWILCDYVSEILDLSNPSNYRDLSKVPIGALNPERLKKFQEKHSSFEDPVIPKFHYGSHYSSAGAVLHYLARVEPFTTLSIQLQGRKFDRADQIFSDIAATWKGVLQDMNNVKELNTTDPNTHMVSSFSNPTTSETEPDSDMNIVSTPSNATTNQIDTESSEAANYENSNSSIKTSKNTSKITKLTPTSKRSLTSSKDNAAQKSSTKPKLLSKAEIIKVDVYSYIMSL
The following text describes a protein:
Function:
Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
Subcellular Localization:
Nucleus.
Sequence:
MAAPGLERDESAGPEENLKAQHEKVQLQDSYTGASYHNVDDRNSSPDVIRSLPHGWKRIVKQRQSGKTSGKYDVYFVSPQGTTLRSRISLAKYLNNNKEINLKLEDFDFSVPDQSQKQRTKKETYRGRNEGRDQKEAIENTQYTKETSVKKSTVCRKRIRSHRKASDKGIIEGRPIKRQRKHSSEHLTQRKQKKAIRSRGPKRELEQKKSKNNKVNIQQELKVSVTAPSPSCDNEEAEILSTLSENDHRCSDTADDQAVPCTPELLCDAGIEETNSDSNRDDGDTFTSEKQTDDFITASQVEKRKTSPYFSRKAIKEALAPPKRKAFTKWTPPRSPFHLVQETLFHDPWKLLIATIFLNKTSGKMAIPALWQFLKKYPNPEVARAADWKEMAELLQPLGLYELRAKAIVRFSDEYLTKKWRYPIELHGIGKYGNDSYRIFCVNEWKQVQPQDHKLNFYHTWLWENHKKLGLD
The following text describes a protein:
Function:
Could be the functional equivalent of DNA polymerase III delta subunit (HolA).
Sequence:
MYRKDLDHYLKQRLPKAVFLYGEFDFFIHYYIQTISALFKCDNPDIETSLFYASDYEKSQIATLLEQDSLFGGSSLVVLKLDFALHKKFKENDINLFLKALERPSHNRLIIGLYNAKSDTTKYKYTSDAIVKFFQKSPLKDEAICARFFIPKTWESLKFLQERANFLHLDISGHLLNALFEINNEDLGVSFNDLDKLAVLNAPITLEDIQELSSNAGDMDLQKLILGLFLKKSALDIYDYLLKEGKKDADILRGLERYFYQLFLFFAHIKTTGLMDAKEVLGYAPPKEIAENYAKNALRLKEAGYKRVFEIFRLWHIQSMQGQKELGFLYLTSIQKIINP
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate. Is also able to phosphorylate the hydroxy group on gamma-carbon of L-homoserine analogs when the functional group at the alpha-position is a carboxyl, an ester, or even a hydroxymethyl group. Neither L-threonine nor L-serine are substrates of the enzyme.
Subcellular Localization:
Cytoplasm.
Sequence:
MVKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFALCDKPETAQRVADWLGKNYLQNQEGFVHICRLDTAGARVLEN
The following text describes a protein:
Function:
Involved in the degradation of protocatechuate (PCA) via the PCA 4,5-cleavage pathway. Catalyzes the oxidation of the hemiacetal form of 4-carboxy-2-hydroxymuconate-6-semialdehyde (CHMS) to produce 2-pyrone-4,6-dicarboxylate (PDC). LigC has 10-times-higher affinity to NADP than to NAD.
Sequence:
MRIALAGAGAFGEKHLDGLKNIDGVEIVSIISRKAEQAAEVAAKYGAKHSGTDLSEALARDDVDAVILCTPTQMHAEQAIACMNAGKHVQVEIPLADSWADAEAVMKKSQETGLVCMVGHTRRFNPSHQYIHNKIVAGELAIQQMDVQTYFFRRKNMNAKGEPRSWTDHLLWHHAAHTVDLFAYQAGKIVQANAVQGPIHPELGIAMDMSIQLKSETGAICTLSLSFNNDGPLGTFFRYICDNGTWIARYDDLVTGKEEPVDVSKVDVSMNGIELQDREFIAAIREGREPNSSVARVLDCYRVLGELEVQLEKQG
The following text describes a protein:
Function:
Cleaves internal linkages in 1,3-beta-glucan. Beta-glucan, a polysaccharide constituent of fungal cell walls, can act as an elicitor in the plant, triggering defense responses including phytoalexin synthesis.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MVNIQTNTSYIFPQTQSTVLPDPSKFFSSNLLSSPLPTNSFFQNFVLKNGDQQEYIHPYLIKSSNSSLSLSYPSRQASSAVIFQVFNPDLTISAPQGPKQGPPGKHLISSYSDLSVTLDFPSSNLSFFLVRGSPYLTVSVTQPTPLSITTIHSILSFSSNDSNTKYTFQFNNGQTWLLYATSPIKLNHTLSEITSNAFSGIIRIALLPDSDSKHEAVLDKYSSCYPVSGKAVFREPFCVEYNWEKKDSGDLLLLAHPLHVQLLRNGDNDVKILEDLKYKSIDGDLVGVVGDSWVLKTDPLFVTWHSIKGIKEESHDEIVSALSKDVESLDSSSITTTESYFYGKLIARAARLVLIAEELNYPDVIPKVRNFLKETIEPWLEGTFSGNGFLHDEKWGGIITQKGSTDAGGDFGFGIYNDHHYHLGYFIYGIAVLTKLDPAWGRKYKPQAYSIVQDFLNLDTKLNSNYTRLRCFDPYVLHSWAGGLTEFTDGRNQESTSEAVSAYYSAALMGLAYGDAPLVALGSTLTALEIEGTKMWWHVKEGGTLYEKEFTQENRVMGVLWSNKRDTGLWFAPAEWKECRLGIQLLPLAPISEAIFSNVDFVKELVEWTLPALDREGGVGEGWKGFVYALEGVYDNESALQKIRNLKGFDGGNSLTNLLWWIHSRSDE
The following text describes a protein:
Function:
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MKYILAIDFGLKKIGTAIANTLDKYPSAFHVFEVKNNFKTAVNNLFLRIKNDGYELEKIVIGFPKFHYYSDIQKAIKSFKQLLEKRFNLPIILVDESNTTSAVKDKLITMDLKHKDFKKAKDTLAAVLILERFFQNYH
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MGYKCIFLYKGLLPEISKRIEFLGGVKVSSTWSISCSLYLERVPDGSNLNPRDFYLLLFDEKPKKCFVVSRDTIVETDREMVSILEKTNSYRKRQTTDILGSKYELGDFIIRIGPIVARTEVRGILVEVEYIACSSPVTSPFNCTKLLSEFINYNLGPFPEPIQTSYDFSAYPTLSKTYSDLHTSYQYVNLLKTIQ
The following text describes a protein:
Function:
Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by ago2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur.
Subcellular Localization:
Cytoplasm, P-body.
Domain:
The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH).
Sequence:
MYSGAGPVLVPPTTTPPLPMPAYTFKPPPRPDFGTSGRTIKLQANFFEMDIPKIEIYHYDIDIKPEKCPRRVNREIVEHMVQHFKAQIFGDRKPVFDGRKNLYTAMPLPIARDKQVELEVTLPGEGKDRIFKVAIKWMACVSLQALHDALSGRLPNVPFETVQALDVVMRHLPSMRYTPVGRSFFTASEGCANPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFMCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPFVREFGIMVKDDMTDVTGRVLQPPSILYGGRVWEEPNAPLSKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKTFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYTGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLSAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDRNERVGKSGNIPAGTTVDTKITHPSEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDQQALAKAVQVHQDTLRTMYFA
The following text describes a protein:
Function:
Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5).
Subcellular Localization:
Cytoplasm.
Sequence:
MANQLVILNVYDMYWMNEYTSSLGIGVFHSGIEVYGREFAYGGHPYPFSGIFEISPGNASELGETFKFKEAVVLGSTDFMEDDIEKIVEELGKEFKGNAYHLMHKNCNHFSSALSEILCGKEIPRWVNRLAYFSSCIPFLQSCLPKEWLTPAALQSSVSQELQDELEEAEDAAASASLASSASGSRTGRHTKL
The following text describes a protein:
Function:
Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Secreted, extracellular space, apoplast.
Sequence:
MVEPDEMIEDEVFVDIKLTNDEIVQWEIMQQMSIECLIRKKKSLRARYTYGIIFSLVNLVAWFLRDYGQRVSLHFHILKGHDCFQTMGVLRVSLGCFIYFFMLFLTTCGTTKLFNIRNTWHSGWWTVKFGILVIILVFSFFIPSDFVQLYGELARVGAGIFLLLQLVSVIEFIAWWNAYWMPDERKKQSSCCGLFMSTLFYMASLCGIIVMYALYASKPSCTLNIFFITWTTVLLLVMMIISLHSKVNKGLLSSGIMAFYIVFLCWSALRRFVIIDRLSLSWFSSEPANEICSPQKHENKHVDWITVLGFLIGVSAIVIATFSTGMDSQTFQLKKQEDQMEDDIPYKYGFFHLIFSLGAMYFAMLFISWNLDSSTRKYKNNIDFFYYYLVFKHHLHTSITIQNNKLPSIFHSLTYNLQDVEAIFIFGILSVSAVDPAPAAAAAGGGGGGGEHVFELYMHDILGGSNPTARPVTGLLGNIYSGQVPFARRIGFRAPQGGVAIPNANGAIPTVNGNGIPLGTGLVGTQFAGNLNQNNVQNQIAAQLGPDGLGLGFGTITVIDDVLTIDPKLGSQSLGKAQGVYVASSADGSRQMMTFTAMMEGGEYGDSINFFGVYHIGSAMSRLSVTGGTGKFLHACGFAEVRSLIPAGQIVADGVESLMRLTVHLSY
The following text describes a protein:
Function:
Plays an essential role in viral DNA replication.
Subcellular Localization:
Host nucleus.
Sequence:
MTNVWFATDVNLINCVLKDNLFLIDNNYIILNVFDQETDQVRPLCLGEINALQTDAAAQADAMLDTSSTSELQSNAST
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
MYTSEGAQAPDFVADQGIYYPVDPNYAYYCTGYESPGEWENHQMFFGADGSQVQYQGGQNENSPYIYYTPSYGYAHAQSPYNPFNPYIPGADSPFVASQQFYPLPPYPTLASSSYAAHPDIVSSSSANSLVETGSAANRGRSDGRGSRNRNASAADGIQRNPPSVSRSSEKPRPNPGGQNRPLSTEKRVSTPFPALQGKAISVSTQSVDVVSSSRVSSSGQLDIAPPPERNGLSSTATNNNNPRPKLYGVHANISSRSKGPRSQLVVKAYTTKAGNADAEGNIVIDPNLYNKEDLRIDYTNAKFFVIKSYSEDDVHKSIKYNVWSSTLHGNKKLQSAYEDAQRIATEKSCECPIFLFFSVNASGLFCGMAEMTGPVSFEKDMDFWQQDKWSGSFPVKWHIIKDVPNSYFRHIILHNNENKPVTNSRDTQEIMMKQGLEVLKIFKGHAERTSLLDDFAYYENRQRVMHDERNRLPYRSFLSPVPVPRPDISDRNKKNSEGPSKSDGNEQTTVKEGSKEDTTTLIQKKITSLTVSPTDTDSNPTTGSHLNQSQAKSKPSPSVSVKKTDPPEVVDSPLSEDSDTVKVGSLPIKVTGSPPIVTVGTIPLDPGSLQKK
The following text describes a protein:
Function:
Essential for the assembly of the mitochondrial F1-F0 complex. May interact with the alpha and/or beta subunits of F1-ATPase (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MLPIWKLPVNHLLCHSFKSIPRTSAYAVRFAHHTSNNDDLEVKKNTVYERYERKLKSKAEELHMPVTNLLKKGQTKEREHVIPKKSFSAKKSLVGQNAKKSDLSGLNRYIDVEKIKELPTSTIEKLWRARNIGDDILSACIPKEIYEKMLSRARMYPYFVLPLPRGDKGIESHFLQWNFPNKNEAHLLVTSLLEYKLKGSYAAPHTIMLHFADLLNLKGITLMRCQFEPKKLSANDVQLLVLAIQKFYNASENTPLGKERLALLAAFSKGADFDLHKVATHMDMLE
The following text describes a protein:
Function:
Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (By similarity). Reduces kainate receptor-mediated currents in brain neurons, most probably by modulating channel properties (By similarity). It is required for proper heart development.
Subcellular Localization:
Perikaryon. Cell projection, axon. Cytoplasm. Cell junction, desmosome. Cell junction, adherens junction.
Sequence:
MVLILGRRLNHENSGGVPESPAIKRKVFEMETKTLSDVFNFSSGSSHSESVLQVFNEFRDSRLFTDVIISVQGREFPCHRAVLSACSSYFRAMFCNDHRESREMVVEINGIQADAMDTFLQYVYTGRACITTLNVQFLFETSSLFQITTLRDACAKFLEEQLDPCNCLGIQRFADAHSLKQLASRCRTFALLNFPEVAQHEEFQDLRKDELEEYLASDELSICREEVVFEAVMRWVYHGVEYRRPMLKDLLQHVRLPLLHPNYFVQTVEGDKLIQNAPECYQLLHEARRYHVLGNEMMSPRTRPRRSTGFSEVIVVVGGCERMGGFNLPYTECYDPVTGEWTSLAKHPEYTKSEYAVCALRNDIILSGGRINSSYVWMYNSQLNVWIRVASLNKGRWRHKMTVLLGKVYAVGGYDGQCYLNNVEVYDSFSNRWTEVAPLKEAVCSPAVTSCAGKLFVIGGEPDENSCSNKVQCYDPESDSWQLKACLPFTKPNISAVSLNHLIYVCGGLTKSIYCYDPSQDHWMHVGHTFSRQESCGVSVCNGKIYILGGRGENGEASNNVVCYDPSSGIITSTAAMPRPVSYHGCVTVHRFSEKQHKP
The following text describes a protein:
Function:
Magnesium transporter that may mediate the influx of magnesium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEFTKPALMRRLDLPGRDLRMLDPFFAYPTTILARDRAIVCNLEHLRCIIAADEAFILLRDGGFGAEDARIRSCAAELQRRLVQAAGRRASDDSQVDGTPFEFIALRVALQDVCSLFESQTAELQSEGYLALDESKKIINVVSLERARLLKNRLAILTSRAEKVKDEIEMLMDDDGDMAECCLTEKKRKMEASLLEKRIGESSNDSFESLDMNKFGTEELEMLLEAQFASIGSSINKLTMLMEYIKDTEGFINIELNNVQNQLLKLELLLGSAAFVVATFAVVPGVFWMNFEGVKLYKVPHGFEETLVITGVCSLVMLGCFAWYLKRRMIF
The following text describes a protein:
Function:
Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA. Requires TrkE (sapD) for maximal transport activity, low activity is seen in its absence; no further stimulation is seen with SapF. Transport in the absence of SapD is dependent on a high membrane potential and a high cytoplasmic ATP concentration, suggesting this protein may be able to interact with other ATP-binding proteins. Can transport potassium and rubidium.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNTSHVRVVTHMCGFLVWLYSLSMLPPMVVALFYKEKSLFVFFITFVIFFCIGGGAWYTTKKSGIQLRTRDGFIIIVMFWILFSVISAFPLWIDSELNLTFIDALFEGVSGITTTGATVIDDVSSLPRAYLYYRSQLNFIGGLGVIVLAVAVLPLLGIGGAKLYQSEMPGPFKDDKLTPRLADTSRTLWITYSLLGIACIVCYRLAGMPLFDAICHGISTVSLGGFSTHSESIGYFNNYLVELVAGSFSLLSAFNFTLWYIVISRKTIKPLIRDIELRFFLLIALGVIIVTSFQVWHIGMYDLHGSFIHSFFLASSMLTDNGLATQDYASWPTHTIVFLLLSSFFGGCIGSTCGGIKSLRFLILFKQSKHEINQLSHPRALLSVNVGGKIVTDRVMRSVWSFFFLYTLFTVFFILVLNGMGYDFLTSFATVAACINNMGLGFGATASSFGVLNDIAKCLMCIAMILGRLEIYPVIILFSGFFWRS
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MYLVDQRVCIPTDPEQFKIVQEALKMGFLHQMISDISGAKYTLFIFIVLGICFTLAFTYLLKWCSKTVIWFIIFIIVVLSIFFGYYSYLQYKAASSMTIGLSPTGYLLQAIIWWCFGLGTIILTICFYKRINLAIAIIKSASDFVTKNVSIVIVPVFSTIATLILTVIFIYIAFIICSTGTPGDKQQQWPFGQLKYTLFEYFSGFYLLFATFWTYALIIGVNSFIIAGSVCVWYWQQGKSGQEHVQPLNSSWKRCFVYHFGSIVLGALLLGLISIFRSFFEYLYRNAEYMRTTDGCQFCFKCCACCIWCFERFLQYLNQNIYVQINMTGDGFFHAAKKGLDIMSNNPSIVMQVVGLGDLINNIARIMITLSISMFFFRSISELPQFLFGGIVINPYNPTLLLAIIVFVIATVFTNIFGVAIESILHLYCIDQEIARAKSGSEDAEMCPAALREFLNDKVFTQQK
The following text describes a protein:
Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSESIKANSEDHKEGKNDRSSNGILASDDERVLAQKALLQFHSRKYEECLRTINELLEIRQNDPKVCHNLGVAQFYKSSCTKLDELTKVFDSVLIQPRYEFLPTWFSGENGEDQDSVDEFDQAALNYNKALILYFFRQYEKASDIIEGLFKIIEPLDENLACKICFLAADLSFATRQANMAGEKLAYIEKMITSSEKGSTNQHHEKSETFFTVGGGTKHGLQSESLQMKFNQMKKHNLAALYCKKAMNVNEECIQKPNDSGNINSLSAVQALNRHYELLYNIGIELLFSNRPLPGFEALIQCMQAFNTDPKYWFRIAECCISAYRMGEEEIAAKAQNKSYIVSTVVGVGQHQKTVLKPTADYSYRYLPPSHGISVANPEPSLKFALPCLKNALLLLSSVNYNNNDQAIQRNDNSRSRAKVYFSPSAAGMNAHDIIALRYAILAAIAFVSLQLGELVLALERSKELLALPSLPGLYRYLGHMYAAEALIRLNKIDEAVQHLSPETITDISCSFSTQPETTSENKTEADNISSAATRHKFPRTIESARALMFVNLASAYCLQRKPEKARKCIEQASVLRLEKEHIPGAVLISIYIELANGNVASALEVLKRQQLYPFQRNNGSKNIRNS
The following text describes a protein:
Function:
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
Sequence:
MGGLMVNAALLRQVLVGFLREEVHKVGVRKAVLGLSGGIDSALVAFLAAEALGPDNVHAIIMPYRTSNPESEAHARLVAEQLGINHEVIEITPMVDAYFTRFPDADNMRRGNKMARERMTILYDHSAALGALVLGTSNKTELLLGYGTLYGDMASALNPIGDIYKTQVWQLSETMGVPRQIIEKKPSADLWAGQTDEQELGFTYREVDELLYCMIDLRMNRLELLARGFVADFIDTVSGKVQNSHFKRRLPVIAKVSNRTIDRDFRYSRDWGK
The following text describes a protein:
Function:
Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, cilium axoneme. Note=Low levels also present in the nucleus.
Sequence:
MEKYHVLEMIGEGSFGRVYKGRKKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRWPSTISSCFKNFLQGLLTKDPRQRLSWPDLLHHPFIAGRVTIITEPAGSDLGTPFTSRLPPELQVLKDEQAHRLAPKGNQSRILRQACKLMAEEAKQKEDQNAGSALEQEDGLCKVTPSTAPVPGLKATPQESSLLAGILASEMKNNWEDWGAGEAPRTSRENHINLECEQGFPEPRPEAMGRQSTDVVDPENEEPDSDDEWQRLLETSEPGPVQLKSPLTLLCNPDFCQRIQSQLRGTGEQILKGVLDGVSHLLPVLRILSSLLSSCNDSVLLYSFCQEAGLPELPLSLLRYSQESSSIQQQPWYGALLRDLVAVVQAYFSCTFNLERSQTGDSLQVFQEAASLFLDLLGKLLAQSDDSEQTFRRDSLMCFAVLCEAVDGNSWAVSKAFYSSLLTTQRAVLDGLLHGLTVPQLPFHTPPGAPQVSQPLREQSEDVPGAISSALAAMCTAPVGLPSCWDAKEQVSWHLANQLTEDSSQLRPSLISGLRHHVLCLHLLKVLYACCYISERLCHILGQEPLALESLLMLVQGKVKVADWEESTEVALYLLSLLVFRLQDLPSGMEKLGSEVATLFTHSHVVSLVNAAACLLGQLGQQGVTFDLQPREWIAAAAHALSAPAEVRLTPPYSCGFYDGLLILLLQLLMQVQGKPGLIRDVVGSEVWTILWHRFSMALRLPEEVSAQEDDLLLSSPSSLEPDWTLISPQGMAALLSLAMAIFTQESQLCLSHLSQHGSVLMLTLKHLLSPSFLHHLSQAPQGPEFLPVVVLSVCKLLCFPFALDVDADLLVGVLADLRASEVVVCLLQVCCHHLSLLQAELPIGLLTRLALTDSASLKQFVNTVATSSRAIISFLSVVLLSDQPLMISDLLSLLTHTARILSPSHLSFIQELLSGSDESYRPLRSLLGHSENTVRVRAYGLLGHLLQHSMALRGALQSQSGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDAQDGIRRNAASALGNLGPEGLGKELLKCQVPQRLLEMACGDPQPTVKEAALIALRSLQQESCIHQVLVSLGASEKLALLSLGNQLLPNSSNRPASVRHCRKLIQLLRPTHST
The following text describes a protein:
Function:
Required for arbuscular mycorrhiza (AM) development during AM symbiosis with AM fungi (e.g. Glomeromycota intraradices).
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MRSERHVMKMKDLKFGPQLIATLLVLCFCYTYAVAEVKKQTKKTFIIQMDKSNMPANYYDHFQWYDSSLKSVSESADMLYTYNNIIHGFSTQLTPDEAELLEKQSGILSVLPEMIYKLHTTHTPEFLGLGKSDAVLLPASASLSEVIVGVLDTGVWPEIKSFGDTGLGPIPSTWKGSCQVGKNFNSSSCNRKLIGAQYFSKGYEAAFGPIDETMESKSPRDDDGHGTHTATTAAGSAVSGASLFGYASGIARGMATEARVAAYKVCWLGGCFSSDILAAMEKAVADGVNVMSMSIGGGLSDYTRDTVAIGAFRAAAQGILVSCSAGNGGPSPGSLSNVAPWITTVGAGTLDRDFPAFVSLGDGKKYSGISLYSGKPLSDSLVPLVYAGNVSNSTSGSLCMIGTLIPAQVAGKIVICDRGGNSRVQKGLVVKDSGGLGMILANTELYGEELVADAHLLPTAAVGLRTANAIKNYAFLDPKPMGTIASGGTKLGVEPSPVVAAFSSRGPNLVTPEVLKPDLIAPGVNILAGWTGGAGPTGLTNDKRHVEFNIISGTSMSCPHVSGLAALIKAAHQDWSPAAIKSALMTTAYATYKNGENLLDVATGQPSTPFDYGAGHVNPVAALDPGLVYDATVDDYISFFCALNYSASDIKQITTKDFICDSSKKYSLGDLNYPSFSVPLQTASGKEGGDGVKSTVKYTRTLTNVGAPATYKVSMTSQTTSVKMLVEPESLSFAKEYEKKSYTVTFTATSMPSGTNSFAHLEWSDGKHVVRSPIAFSWT
The following text describes a protein:
Function:
Transcription factor that regulates the expression of the gene clusters that mediate the biosynthesis of trypacidin, a metabolite with antiprotozoal activity and a possible role in the infection process. Trypacidin is toxic for human pulmonary and bronchial epithelial cells by initiating the intracellular formation of nitric oxide (NO) and hydrogen peroxide (H(2)O(2)), thus triggering host necrotic cell death.
Subcellular Localization:
Nucleus.
Sequence:
MRSPASSRRASALHRLCDSCRACGLSKVRCSKEKPTCSRCRRRGTVCEYVVTKRPGRKPDSRSEVEPEPGHLSHPLPSPESSTAISQGNLPDPDAFDPLFALPEPFDSTPELHSGPLSTVDSSLSSALTTWCPDFDDFFSFPVSTEDTLSGDRGAVYDGTIKHPPNLRRHSESPPAVPDDTIYLFGKPVDPAPPDQSLPATTTIGRRASPPSGRESEAGSRRLSCRCLIRALDLLKHFEVIRREAEIESSLPSIDAVVEVNKQTTEAITGMLQCPCSQKDGYLLVLLALIVCKILDRYAAAAIPGTEQGHDPTRRLDEGPMAGQRVLGELHCIQRVMNQLGPRLRMHGAQGASPGQAFHGTPAPLSVGLGDQLEPELHQRLSRLSSEIIRLLREAQ
The following text describes a protein:
Function:
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAAKGSTLVVTLLVMGNVIIMLAGLALYAESIWVTADPYKVYPIMGVSGKDDVYAGAWISIFTGFSFFCVCVFGIISLVNGNRLMVLLYLVLILVVYLFECASCITSYTHRDFVVSNSRLITKQMLSYYSEDSYQGRELTRMWNRFMMEQQCCGTNDPMDWVNYTSVFRRRYPEIVAPWPFFCCKRDRNFIIINEEGCRLGHVDYINTQGCFEHIKHAVQSYAWGVSWFGFAILMLTVSSSKKEISGIVQRTQPLFDPAA
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
MAAVAPAAGHAADLLQKLSLDPKSEGGKGSETNEKASGGLNGVSKGAVVSPNPPVLSAEPWAQQDYMDAAMYYGGYPGAYYCGGWGDYSVYVSQDGADALSSGVYGDMYCYPQYGIADGQIYGSQHYQYPSTYHQPKTTASKPAYKAKTGKSTPSSQEDVSTATAADQQPVLLDSSKITPKSIDGVKGPKKETLPLKPNERLGNYQNQGSKTAYSWSGSSTSSEKHPKLSGGSPTSTASNRNNKGQNSPMGPPSSGFMSSIYSGSGMYNTNAYTPSFWYGSHVYGPGLYGGWNALSNGKYRPRGKTYGSYGFGNENLDGLNELKRGPRGGPFKTQQGPGAAADAKGQELPTSDGSNAVKQDQYNRADFVETYSDAKFFIIKSYSEDDVHKSIKYNVWASTPSGNKKLDAAYVEAKEKSSSSPVFLLFSVNTSGQFVGLAEMVGRVDFNKTVEYWQQDKWTGCFPVKWHIVKDIPNGLLKHIILEYNENKPVTNSRDTQEVKLDQGLQVLKIFKDHVCKTSILDDFGFYDNREKIMQEKKSRRQYPVEKVVNRKLLATNNTENEATDGKQSLQKSEAVGEQNVVKNGAVAVAANGVPPRDETPVVENGAMAVAANGVAPKDANPTTEVVAVANGC
The following text describes a protein:
Function:
Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones.
Sequence:
MTRAGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSNEEDILSMFSAVRSQHSGVDICINNAGMARPDSLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMCGHRVPPQSVIHFYSATKYAVTALTEGLRQELLEAQTHIRATCISPGLVETQFAFKLYDKDPREAAATYEHIKCLRPEDVAEAVIYVLSTPPHVQVGDIQMRPTEQVT