lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (By similarity). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). May contribute to COPII-coated vesicles formation and ER-Golgi vesicle transport. Together with SEC23A, essential for pollen wall development and exine patterning, probably by regulating endoplasmic reticulum (ER) export of lipids and proteins (e.g. sporopollenin) necessary for pollen wall formation. Also involved in plastid physiology in anther tapetal cells.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=Observed at endoplasmic reticulum exit sites (ERESs), characteristic for COPII-coated vesicles localization.
Sequence:
MAVRATVSRFPIDSDAQEASGLPWGLTVTPFAAKDENGIGPACGSNGHLLPRCENCYAYFNTYCELDQWAWNCSLCGTLNGLPSDAIARYSNPHSIPEMTSSFIDLEMPLDGSEEEMTQARPVYVAAIDISSSEEFLELTKSALLAALEALSPGALFGLVTFSHKIGLYDVQGPIPVVKNVFIPPDGESSLSLELEDVMPLLQFLAPVETCKDRIAAALETLRPITSWERSAGAGQGMDSVLMGGRGFGTAMEALFNYLGSEFGNTFALARVFAFLSGPPDYGRGQLDTSRYGEQYASKRVDADRALLPEQTPFYKDLATIAVQSGVCVDLFAVTNEYTDLASLKFLSIESGGSLFLYSSTDDSTLPQDMFRMLNRPYAFNCVLRLRTSTEFKPGNSFGHFFPDPQYENLQHIICCDSYATYAYDFEFADNTGFSRHSGEQPVVQIAFQYTVVVPPEGLSNSEMSSSSRGKHTLQRRLRIRTMQFGTAHNINEIYDSVDHEVVLSLLVHKVILASLEDGVREGRALLHDWLVILTAQYNDAFNLVQYKNGNKSMSSQIDITFSQCPQLEPLPRLVFALLRNPLLRFHEEGVHPDYRIYLQCLFSVLDPSSLHCGIYPALMSYSTPDTLAYPRHSLSRAALITSGSPIFFLDAYTTLIVFYSSTADPSIPFPPPQDCLLRQTINKVKQERSITPKLVFIRGGRDDATVFENYLIEEQDVDGNGFASAMGFVSFLDDISQRVTEYMK
The following text describes a protein:
Function:
Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEDENILRNAVNLQVLKFHYPEIESIIDIASHVAVYQFDVGSQKWLKTSIEGTFFLVKDQRARVGYVILNRNSPENLYLFINHPSNVHLVDRYLIHRTENQHVVGLWMFDPNDMSRIFNIVKESLLR
The following text describes a protein:
Function:
Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants (By similarity). Degrades cutin, a macromolecule that forms the structure of the plant cuticle (By similarity). Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of fungal infection (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MSLTLFSFLSLVSILCIVTAAPVTNVNFTSIQVSSMQHIAAINKASFFSPTALPANATENGLTGSCKPIILIFAKGTGENGNVGDGSSPGPAWFSELRNAIGEDKIAVQGVQYEADVFGYLVGGDPEGSQNYLTITNQAVTQCPNSKIVIGGYSQGAQITHNAAQLYSPLVTSRIAAVVLFGDPYTDKPVGQVSPSSVLEICHDGDIICTGSGGPDPHLTYSKNATCAAKFVLDRI
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MADVIIIDVWADNVHEEFSRIRDVVHRYPYIALDIEFPDFVHPCNCRADARIYYGHIKANVFDFEKNPTKGVTSQTLADSLASARLVSNPAVHWVTFHGTYDMAYLVKLLNGCTLLPDALSTFHSMVNRIFPNFYDAKHMVHHHYVWTGGLSKLARDMGVQSSALNMHQAGADSVVTAKEFFVLKKRVIKRGCVGECNRLLNGL
The following text describes a protein:
Function:
MHC class I receptor. Binds only to H-2 class I histocompatibility antigen, K-D alpha chain (H-2K(D)).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAADDKVAILTDDEEEQKRKYVLADPFNGICREPEPPSNETPSSTETSAIPEEEIDWIEKHCVKVNNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLFNLGIGFVKPATLRCLPKIPPTAHPTNVSHPVTVLPMNSSTVAFFSTPPKLLQKRDVQLSETEPNISDIDLVSTALTLTSEPTRRPQTEAITHPVTGLILNTSTVTLPPTGNVTRETTIAVVTTTKSLPSDQVTLVYDQQEVEAIFLIILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIDVLIDGKGCKPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNHFNNSDGKGKEVEIPQVERDNSTESSEETPTAATHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQWLAVPDEEEDKTMLAERIPVPSSPVPIATIDLVQQQTEDVMPRVEARLPPKKTKHQEEQEDVNKPAWGVSSSPWVTFVYALYQVKELIQLTRESRASEIQPLQVTLCWASVASAPLLPPCSSKHMGNRKTGMLAKDISGLRSLCHSVYQVA
The following text describes a protein:
Function:
Serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex. May play a role in the regulation of synaptic vesicle exocytosis.
Sequence:
MSASSEHSEPDIVQPPKYGRVEYRMEHFGDVRTDPYHWLRDGRSSEVRKLLRRENAHMESAFAAYGGKRLSRTLYNQMRARWKEDEASLPYRDRSYWYYSRTVPNADHPLFCRRPVSVDSGTFVEEVAHLWAQDPHAPLPAYEDEVVFFDLNLFARELRLDYVELGDMEVSPDEQQLAVTVDCSSGREVFTIFIVEITNVNYEQWLHQHSELGRAWAVAMAQSKLSIYNSPTSALPRYSSSKSFSAADDYTSRTSRKSVSTGDIVDAFQSAPSSSQFTSGAGDVSVGGSERGSTNAFVTSADAFFAASAFSRKPAPSHKVKRRIDVFDATDEVLWLSSTTLLYLGLDSRMRSHRVIFHDLAADEDSPHSDVICYEEPNEAFWVSSLCYSADDRFAMFTTSSSGSTQVYVMPCDEGKKRWVSGVPVVHCGFASGGDSDDIRSNGGPTCSTSRTASIHTTRSNADFVGGGHASAAVHRFTDRAEDVDLDLDHHSSLFGEAIGAWVIVITSLKRGSGHWRVAYVLDDKMLWDESQNLSLCESTMWQTLFTYDPQIFVEGVECWRDYLLLSVRQAASSTVLLLPVRKLWSHWLDNRDSGSSCLPPLSVRHDALDLRAVVCYPLVSVSNVCFSIEKFYQMQWREQERQEFEGGLGESDCVHFVRSCAGDDVFDTRTWRLVVAHPTIPSVTFSCTLGGVEEGEMSLSVKKLYQVPVGGTPFCADDYDATIVWVPSDYGFRSDLLLQMLPTKEPSDVVGIPVYLCWKKSLLERGGNPMFLTVYGSYGECCDVDFESERLALLDRGFVWGAAAVRGGGELGTGWRVAGRKLQRGTTVNDFVSVASFMQKTGWCADGRLVVSGASAGGFVVTAAMNIAPHLFLAVVASVPFVDCLTTLLDPTLPLTVSEWEEFGNPLEDAEAYSIIRALSPMDNIPPPGVALPHIMMLTAWHDTRVGYWESLAFVARLRERREKERASRGNTSMCDGKPCAERAILHYCDFAVGHGGATGRYQRLKEVAREYAFVVLVQEAAEQSST
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MECLEPLDLSVAQRPVLLKNETIFITTKDVCLYFGNQRLIEFNSGLVYVTSHRIMWVNETRHHAVQLHLAHIRQIDYSNGFLRSSPKIILDLLPSEISALHSTSPTFISFSKSTQDLVYNPSQSTESILPEWKCEVCDEMNGANAAKCAMCGVPNTNSPIPNSQAVCASFPQTKTTSTAASNEWTCEICDAVNTSDVSKCRNCGVQTVNSSNHNIISDINSSLPSKSTQIKCTACTFLNHPDLTSCEICNAPLSSASQLPESNPSDFGSSPIEDATQSKLNLKSTGPGSILKLSFRGGGMTDTLKHIKQVVAVKAWEKVETPTTPNPSISIQPNQASIGGVSGIIRNVEQTRKQMNDTVGDAFSDLENLMENAAQMVKLAESISNKLASLSIASDSSEMLTFRNYLNEIGISNPVTKESAGDMFIQELSRQLTEFLDQMRLAGHSEMIPLTDLYCLFNRARGVALISPDDLYKSVVEFERLKLPFRLRKFDSGLLVVHYSDEEVASKILKLVAERQTGLTAVELAKLTSISIVLAAEQLLMTEQVGLTCRDDTLEGLFFYPNLFT
The following text describes a protein:
Function:
Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Required for Golgi glycosylation and cell wall integrity. Involved in N-mannosylation of proteins in Golgi.
Subcellular Localization:
Golgi apparatus. Membrane; Single-pass membrane protein.
Sequence:
MVRKYGIFIDAGSSGSRLLIYSWDYDTDSSLSDKVKKLPLIETGIGDGGKWSLKVQPGISSFANNPKHVGKKHLKELLDFAAHAIPKDVHKETPVFLSATAGMRLLGVDAQNKILSHACRYIKKNYDFDIPNCSNSIRVIDGKAEGMYGWLATNYLLKTLEEKDTSTVGFLDMGGASVQIAFELPPSQLKNYKDSISTVHIGLQNGQQLEYPLFVTTWLGFGANEAYRRYLGLLIESENGKVGNTLSDPCSLRGRTYDIDGIEFAGTGDLKQCLKLTYNLLNKDKPCSMDPCNFDGISIPPVDFANTEFVGVSEFWYTTNDVFDMGGSYHFPNFYKKVDEYCGTEWETMLSRLYNKELTPSTDENKLEKLCFKASWALNVLHEGFDVPKSNTSSNDAKDGLSVIPAYHSPFTSLEKIERTEVSWTLGQVLLYASNQQLLAKPEYANYYMDPYGKLIASPSKHWMRLFPNKLFFILSFIFCLFFLFSLVLFGYDPKRRQRFKKFLLRLQRRKAPYIMSANGSYEDIADFSDDLEMSSPSKWHGPPIRTTSSHVLADRLSFTASRERTPRSPFP
The following text describes a protein:
Function:
mRNA splicing factor that regulates alternative splicing of many genes in embryo. Probably plays a role in the formation of embryo-specific isoforms.
Subcellular Localization:
Nucleus.
Sequence:
MNRQTSHPEQRLLLIRVSDGNYDENTKLVVTSFYPRRQEDANNNSTSPSSASSSGSEISTRLVNITPEDVVKFFDEHPTSSYIFTKGPEPIRHVLIPLFARNELCVPHPLHHYYDIKHLYYGNQEEDGMEQEEIEDDVAIARAILDMDDELLEKTHQFVNIEYQPAPILEDQEVGADGDNVVCRARGLPWQASDHHVAQFFAGLDIVPGGIALCLSSEGRRNGEVLVQFSSQESRDLALKRHRNFLLSRYIEVYKAGLDEFMHVATGSSTEAMEFVSANAIIVRMRGLPYDCTDAQIRTFFEPLKLTDKILFITRTDGRPTGDAFVQFETEEDAQQGLLKHRQVIGQRYIELFKSTAAEVQQVVKRCNLINSSPAVANAVEAPEEKKKDCVRLRGLPYEATVQHIVTFLGDFATMVKFQGVHMVYNNQGHPSGEAFIQMINEQAASACAAGVHNNFMSVGKKKRYIEVFQASAEELNLHHLVGQQHQVPPPAPLGFMGQLPPQAPQPQQFWSSYPSPPISPIVPGQVTQLIIYGIHMSIGVPELVANFTTPEHTVDNVLFTRWPTHLCPGEAILTLRNRGAPPPQTSPLSQISQLSAPNFAAYSHHPQNFPLQPILME
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MIFLFQIYYSCLGEKKISQLRDSLITEVSKFLSVSRGIACTLLVQNRWSTTLLYDKWFSDEKSVREAVGLLPEKQESPKQLDFCCCNICFGEIKIENTLSAPCGAHPFCLDCWKTYLTVSINNNGPGCLKMPCPEPGCKAYVGLDIVDSLASDSDKDKYYGYLSSSYVEGTLNLKWCPGPGCNLAIRLDEYGPKGYDVTCDCSHRFCWNCLEETHRPMDCETADTWRKQNTCFEADTKWSHDHYCNEYEDEKNEGESTSVDTDNSKYFDGYEHYYERWLSNHKSREIAVANLKCARNGIIETLACVQGEKKWKLMFVIDALEQIVECRLVLKWSYAYGYYLSLAKSKKMALFEYMQGDAEAALERLHHCAEKEIQKYVLCPSPDFNDFRVKLTNLTCAAQTYFENLVTAFEDDFRF
The following text describes a protein:
Function:
Putative G protein-coupled receptor for pyrokinin-like neuropeptide derived from the processing of the neuropeptide precursor capa-1.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSQCTVEYNVSEITEYVLSTLGERCQSAGIVIPTVIIYGTIFLLGLFGNICTCIVIAANKSMHNPTNYYLFSLAVSDIIALILGLPMEFYQSLDYSYPYRFSEGICKARAFLIEFTSYASIMIICCFSFERWLAICHPLRSKIFSTLWRANVLIILAWTISFVCALPIAFIVQINKLPLPEDAKYQPWTNKVSTDGIFVLHTEFCAMNQSRPDQQKMIIIFAFTVFFVIPAIAIVIMYAHIAVQLESSEIDLKGDKMVKKRRNKSNRTVLKMLLSVVITFFICWLPFHIQRLLSVYTTWSETTTISPPVQFLSMIVFYISGFCYYSNSAANPILYNILSQKYRSAFCRTILGDHIANFVFKGHQRPGQSKRCSSSTEAEQRTLMTRGSVRVDKPHRKLEVHNY
The following text describes a protein:
Function:
Has a role in female meiotic chromosome segregation in females; proximal heterochromatin is involved in chromosome pairing during female meiosis. Is a dominant suppressor of both white and Stubble position-effect variegation (PEV), while it is a weak enhancer of brown variegation.
Sequence:
MSRWGKNIVVPLDSLCKEKENTNRPTVARSVGTVGKWGKMGFTSTRTYTLPAIHPMAAAAAAAAAAASPSQSPASTQDHDPNDLSVSVPEPPKPKKFFKSRNTAPPEVIAQIIQQLPHCGAGASPMRDHFSSAGAGAGGLTPTSGAQEAGGVKLKPGKGASSAERKRKSPKKKAATTSASTPSTPGAFYGASDRDGDGLSDPASEQPEQPSSASGKQKQKKPKEEKKLKPEAPPSRVLGRARKAVNYREVDEDERYPTPTKDLIIPKAGRQPAEVAATATLAAASSEAFISSTFGSPGSEPSLPPPTSAPSASASTSSQLPSASGSASNPPSASRTPEHPPIVLRISKGTSRLVSTDSEEPPSSSPAHQNQLNQLSVTEEEPAERSGDETVPASTPKITVKPLRPPTAADSVDGSSAAVGGASAGDSFEERKSQSLEPNEDEEEEEEEEDEEEEPPEINYCTVKISPDKPPKERLKLIIKTDVIRNAIAKAAAAAESRSEKKSRSKKHKHKQLLAAGSGAAPASGATPAEINSEFKTPSPHLALSEANSQQAQHTPSHLHQLHQLHPQRGSAVISPTTRSDHDFDSQSSVLGSISSKGNSTPQLLAQAVQEDSCVIRSRGSSVITSDLETSQHSSLVAPPSDIESRLESMMMTIDGAGTGAASAVPETPLQEDILAVLRGEVPRLNGNTDPEPTEEEDQQQQPKRATRGRGRKANNNVDVTPPATETRTRGRAKGADATTAAISPPTGKRNTRGTRGSRKAEQEVDMEVDETAMTTVPANEEQLEQATLPPRRGRNAAARANNNNLASVNNNINKIAANLSAKAEASRLAEGGVAGGAARSYGRKRKNQQVTQVLQQEPVPEEQETPDAEEEQPTPAKIPHTDHREHSPDHDPDPDPDELSNNSNNSSLQHDGSSSSPPPRDFKFKDKFKRTLTLDTQGAANAGAGGAAAAAPPESSGEQRGAVKLVISKKKGSIFKSRALVPSDQAEQATVAKRHLYKHSWDAALEANGGGTNSDASNASASGVGVAGAKDHLHHLAAGKSDGDFGDSPSSNNNGSSSACSSASTLRGDSPALGKISRLAGKQGVPATSTSSDAFDLDLEPIAGELDLERSAAGASAGGTGATTGGGGATGGGGPVRVDRKTKDYYPVVRNVKTAHQIQEIGEYQEMDDDVEYILDALQPHNPPATRCLSALQLAAKCMMPAFRMHVRAHGVVTKFFKALSDANKDLSLGLCTSAIMYILSQEGLNMDLDRDSLELMINLLEADGVGGSTETGHPDRAGYDRNKQKVRELCEEIKAQGKGTHLNVDSLTVGTLAMETLLSLTSKRAGEWFKEDLRKLGGLEHIIKTISDFCRPVIACDTEIDWQPTLLDNMQTVARCLRVLENVTQHNETNQRYMLTSGQGKAVETLCQLYRLCSRQIMLHPSDGGGSNKEHPGVAMRELLVPVLKVLINLTHTFNEAQPSLGAELLGQRGDVVETSFRLLLLSANYIPDQCVFELSILVLTLLINLCMHTVPNRAALMQAAAPAEYVADNPPAQGSVSALQALLEYFYKCEELARLVEKNTDAFLESNEKGKKKQEEVEETVNNLVQRAGHHMEHTLKGSYAAILVGNLIADNELYESVVRRQLRGNSFKEIIGVLEKYHTFMNLTSSLEAAFVAHMKSTKRIIDNFKKRDYIYEHSDEHDNPLPLNLETTAQVLAVGADASHAATSSTTVGSGSAPSSTSATGTTRAPRVYKTYSSHR
The following text describes a protein:
Function:
Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MIIKHFFGTVLVLLASTTIFSLDLKLIIFQQRQVNQESLKLLNKLQTLSIQQCLPHRKNFLLPQKSLSPQQYQKGHTLAILHEMLQQIFSLFRANISLDGWEENHTEKFLIQLHQQLEYLEALMGLEAEKLSGTLGSDNLRLQVKMYFRRIHDYLENQDYSTCAWAIVQVEISRCLFFVFSLTEKLSKQGRPLNDMKQELTTEFRSPR
The following text describes a protein:
Function:
Envelope glycoprotein that forms spikes at the surface of virion envelope and binds to the host cell entry receptors MYH9/NMMHC-IIA and MYH10/NMMHC-IIB, promoting the virus entry into host cells. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell: following initial binding to its host cell entry receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).
Subcellular Localization:
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Sequence:
MHQGAPSWGRRWFVVWALLGLTLGVLVASAAPTSPGTPGVAAATQAANGGPATPAPPPLGAAPTGDPKPKKNKKPKNPTPPRPAGDNATVAAGHATLREHLRDIKAENTDANFYVCPPPTGATVVQFEQPRRCPTRPEGQNYTEGIAVVFKENIAPYKFKATMYYKDVTVSQVWFGHRYSQFMGIFEDRAPVPFEEVIDKINAKGVCRSTAKYVRNNLETTAFHRDDHETDMELKPANAATRTSRGWHTTDLKYNPSRVEAFHRYGTTVNCIVEEVDARSVYPYDEFVLATGDFVYMSPFYGYREGSHTEHTTYAADRFKQVDGFYARDLTTKARATAPTTRNLLTTPKFTVAWDWVPKRPSVCTMTKWQEVDEMLRSEYGGSFRFSSDAISTTFTTNLTEYPLSRVDLGDCIGKDARDAMDRIFARRYNATHIKVGQPQYYQANGGFLIAYQPLLSNTLAELYVREHLREQSRKPPNPTPPPPGASANASVERIKTTSSIEFARLQFTYNHIQRHVNDMLGRVAIAWCELQNHELTLWNEARKLNPNAIASVTVGRRVSARMLGDVMAVSTCVPVAADNVIVQNSMRISSRPGACYSRPLVSFRYEDQGPLVEGQLGENNELRLTRDAIEPCTVGHRRYFTFGGGYVYFEEYAYSHQLSRADITTVSTFIDLNITMLEDHEFVPLEVYTRHEIKDSGLLDYTEVQRRNQLHDLRFADIDTVIHADANAAMFAGLGAFFEGMGDLGRAVGKVVMGIVGGVVSAVSGVSSFMSNPFGALAVGLLVLAGLAAAFFAFRYVMRLQSNPMKALYPLTTKELKNPTNPDASGEGEEGGDFDEAKLAEAREMIRYMALVSAMERTEHKAKKKGTSALLSAKVTDMVMRKRRNTNYTQVPNKDGDADEDDL
The following text describes a protein:
Function:
Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template.
Sequence:
MFALCDVNSFYASCETVFRPDLCGRPVVVLSNNDGCVIACSAEAKQLGIAPGEPYFKQKERFRRSGVVCFSSNYELYADMSNRVMTTLEEMVPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLKRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTDGVVDLSNIDRQRRLLALIPVEDVWGVGRRISKKLNALGIKTALDLSEQSTWIIRKHFNVVLERTVRELRGEPCLELEEFAPAKQEIVCSRSFGERVTDYEEMRQAVYSYAARAAEKLRGEHQYCRFISTFVKTSPFALNEPYYGNSAAVTLLTPTQDSRDIINAAVKCLDKIWRDGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRAGSAKLMEVLDHLNAKDGKGTLYFAGQGMSQQWAMKREMLSPRYTTRYSDLLRVK
The following text describes a protein:
Function:
Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Binds with intermediate affinity to both IgG2a and IgG2b. Can bind to IgG2a and IgG2b monomers. Does not display binding to IgG1 or IgG3. Recognizes neutralizing virus-specific IgGs displayed on the cell surface of infected cells and triggers antibody-dependent cellular cytotoxicity (ADCC). Confers protection to lethal influenza virus infection. On splenic dendritic cells, uptakes antigen immune complexes and efficiently divert them into MHC class I and II antigen presentation pathways to provide for superior priming of CD4-positive and CD8-positive T cell immune responses. Mediates neutrophil activation by IgG complexes redundantly with FCGR2A. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Also acts as a receptor for the Fc region of immunoglobulin epsilon (IgE). Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of pro-inflammatory cytokines and the late phase of cutaneous allergic reactions. Mediates enhanced ADCC in response to afucosylated IgGs.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MWQLLLPTALVLTAFSGIQAGLQKAVVNLDPKWVRVLEEDSVTLRCQGTFSPEDNSIKWFHNESLIPHQDANYVIQSARVKDSGMYRCQTALSTISDPVQLEVHMGWLLLQTTKWLFQEGDPIHLRCHSWQNRPVRKVTYLQNGKGKKYFHENSELLIPKATHNDSGSYFCRGLIGHNNKSSASFRISLGDPGSPSMFPPWHQITFCLLIGLLFAIDTVLYFSVRRGLQSPVADYEEPKIQWSKEPQDK
The following text describes a protein:
Function:
Decarboxylase; part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B. The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units. Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B. The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B.
Sequence:
MTPPLLALEEHYYSTAIFNSIGETFQRTLQGVPGLADQLRSLGDGRLEAMNRGNISLQVVSHAFTPGGPSAEACRAGNDELAAEIAQISDPQRFAAFAVLPVADPTASAAELDRSVSELGFVGALIDNHADGKHFDGHDYDVLWAKACELDVPIYLHPTWPSARMAENFMGSYPVPVGISLGGPGWGWHPDVGLHVLKLFAAGVFDRFPRLKIIVGHMGEMLPYMLERASDMSTRWGGWGPRDRPLRQVWDENIWITTSGSWSLAPLKCILHNTKVERIMYSVDYPFESNERGLEWFKELEGSGLLTEEQLEMVAYRNAEDLLKVHMKKEQ
The following text describes a protein:
Function:
May function as histone H3 lysine demethylase and be involved in regulation of gene expression.
Subcellular Localization:
Nucleus.
Sequence:
MESMIAKRERLNCNTGQSKQITLNSWPATKKRIPMTVHCGNKRAKSEKKGNAKQLLARKKNPSNRQKLNKDFEFLEDEKIPQAKRHCNGIAKTATLDEEELDEWEEEAIVFMNMKDRRKSRNFESVMVERRPKGITRKLSDHIVTSLSDSSSFSSSSSSGSPVSHLESDFSSTDRCKKNKVKGKRKYVKCHQCMTEERTIVPCMKCKEKVYCINCIRQWYPNIPKEEIAKQCPFCCRNCNCSICLHSSGLIKTSKRDITYQEKIKHLKYLIESMLPFLKQICKMQKQEIEIEAEIQELLPSAVDIPQTLCYSDERIYCNYCATSIFDLHRSCRNCAYELCLHCCQEIREGRLSSCDEVAYEYRNRGYDYVHAGDPLPGSYLNETAKDRTKQSIQWKANNDGSVTCPPREMNGCGDCRLELKCIFPVGWILDLAAKAGEMLRACRIKQGILKHKCAVTGRDTLHHRVSREGTNDNCLHSPTSYDIQKEDLSHFQMKWAKGEPVIVRNALANSTGLSWEPMVMWRALCETEDLHTSLEMSEVRAIDCLACCEVGINTYQFFKGYMEGRSYHNFWPEMLKLKDWPPSNNFEDLLPRHCDEFIRILPFQEYTDPRSGILNLAVKLPPGVLKPDLGPKTYIAYGISQELGRGDSVTKLHYDLSDAVNILTHTADVALGEEQLAAIEKLKMKHKAQDAKEKLERDREDKHPINEGRKGITDQNQYSDNNIDEVGARNSGHSKNTGGALWDIFRREDVPKLEAYLRKHSKEFRHIYCSPVEKVIHPIHDQSFYLTMEHKRKLKEEFGVEPWTFEQNLGEAVFIPAGCPHQVRNLKSCTKVAVDFVSPQSIKECLRLTEEFRQLPKNHRAREDKLEINKMIIYGVERAIRELSDLISTPN
The following text describes a protein:
Function:
Could act as a modulator of glutaredoxin biological activity (By similarity). May play a role in cytoskeleton organization (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Cell projection, ruffle membrane. Nucleus.
Sequence:
MSGRRVYSTSVTGSREIKSQQSEVTRILDGKRIQYQLVDISQDNALRDEMRALAGNPKATPPQIVNGDQYCGDYELFVEAVEQNTLQEFLKLA
The following text describes a protein:
Function:
Sesquiterpene cyclase that first catalyzes the cyclization of farnesyl diphosphate (FPP) to the bicyclic sesquiterpene (+)-beta-caryophyllene intermediate, and then its conversion to (+)-caryolan-1-ol via a second cyclization and the addition of a water molecule.
Miscellaneous:
MISCELLANEOUS: A study of the reaction mechanism indicates that (+)-caryolan-1-ol is synthesized by a proton attack on the C-8/C-9 double bond of (+)-beta-caryophyllene.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MSQITLPAFHMPFQSAGCHPGLAETREAAWEWAAAEGLDLSVPARRKMIRTRPELWISLIFPQATQAHLDLFCQWLFWAFLVDDEFDDGPAGRDPLMCERAIARLVDVFDGAAPNGPMERALAGLRDRTCRGRSPQWNRQFRRDTAAWLWTYYAEAVERAAGQVPSRAEFAKHRRDSVAMQPFLCLHEITAGIDLPDSARSLPAYIALRNAVTDHSGLCNDICSFEKEAALGYEHNAVRLIQRDRGSTLQEAVDEAGIQLARIAERVQRAERELIEEIEAAGIDGPTRTALERCVRDYRGLVRGDFDYHARAERYTRPDLVELDERDSLSRHFAA
The following text describes a protein:
Function:
Involved in ciliogenesis. It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length (By similarity). Acts as a positive regulator of hedgehog (Hh)signaling (By similarity). May participate in the trafficking and/or retention of GLI2 and GLI3 proteins at the ciliary tip (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized to the proximal region in cilia. Stimulation of Hh signaling leads to redistribution of ARMC9 toward the ciliary tip within 6 hours, follow by a gradual return to its original proximal location (By similarity). Localizes to the daughter centriole of the primary cilium in RPE1 cells (By similarity).
Sequence:
MVDVLAHESELLGLVKEYLDFAEFEDTLKTFLKECKIKGKPLSKSTCGSLRDPKSLKFQRDLLAAFDSGDQKVFFRLWEEHIPRPIRDGDSLAQKLEFYLHIHFAIYLLKHSAGRPDKEDLDERISYFKTFLETKGAALSQTTEFLPFYALPFVPNPMAHPSFKELFQDSWTSELKLKLEKFLALMFKASNTPKLLTLYKENGQSNKDVLQQLHQQLVEAERRSMTYLKRYNRIQADYHNLIGVTAELVDSLEATVSGKMITPEYLQSVCVRLFSNQMRQSLAHSVDFTRPGTASTMLRASLAPVKLKDVPLLPSLDYEKLKKDLILGSDRLKAFLLQALRWRLTTSHPGEQRETVLQAYISNDLLDCHSHSQRSVLQLLQSKSEVVRQYTARLINAFASLAEGRRYLAQSTKVLRMLEERLKEEDKDVITRENVLGALQKFSLRRPLQTAMIQDGLIFWLIDILKEPDCLSDYTLEYSVALLMNLCLRSAGKNMCAKVAGLVLKVLSDLLGHENHEIQPYVNGALYSILSIPSIREEARAMGMEDILRCFIKEGNAEMIRQIEFIIKQLNAEELLDGVLESDDDEDEDDEEDHDTMEADLDKDELIQPQLGELSGEKLLTTEYLGIMTNTGKARRRGTAGVQWGGPEPLRRPVTPGGHRTGYPA
The following text describes a protein:
Function:
Catalyzes the oxygen-dependent ring fission of gentisate between the carboxyl and proximal hydroxyl groups at positions 1 and 2 of the aromatic ring to form maleylpyruvate. Can also catalyze oxidation of alkyl- and halogenated gentisates. Exhibits higher affinity for 3-substituted gentisates than for gentisate but has higher activity with gentisate.
Sequence:
MLDEEERITMSHELGRLEDLPQDYRDELKQLNLVPLWPSLRAVLPPNVPTRQTQPTYWSYQTLKPLLLKAGELTPIEKAERRVLVLANPGHGLEKMQASAAIYLGMQLLLPGEWAPSHRHTPNAVRMIVEGEGAYTTVDGEKCPMSRGDLILTPTGLWHEHGHDGNEPVVWLDVLDLPLVYYMEASYHIDGERQQVDPGRGDCAWTRAGVVPTPVFQRSDKRYPLLRYPWADTRAALLSLAADQPEQECVQVTYVNPETGDDAENILGFYALMLKPGQTLRLPVRSPAVVFHQIEGRSEARIAESTFALREADTCCAPGYTEVTLKNLSADQPSFIFMADESPLHRKLGVFENRG
The following text describes a protein:
Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
Sequence:
MSTQEPATSSSSTDPAVSDVKLERKARKEAQKALKLQQAAQKKIAIKAEQPSTASSSISKSSSANASASASSSSSSSLKAPRKPPSSDEQLSRALAYILRHGAEKEALEIRADGYVLLEHVLQRPRVKSVTITLPDGKKTKPRLEDVRRIVESNEKKRFELSQQNSAEWWVRAVQGHSLKNVVELQHVALTLENLHLLKLTHDDPHNHSLTEEHHLKTNLDALQIASEHRVQVIHGTYAPAWDLILASGGLKPMTRNHIHLAKGKFGQQGVISGMRKSANRLIYIDIVKAITDGIPFYLSSNGVVLTPGDNQHHMLGVQYFTKVEDQNAQLVWSRPPSPSPSPSPSPSPTV
The following text describes a protein:
Function:
Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
Sequence:
AMAFKAAVVSFLIGIVVAEPVALKAPTSVLSESTVNLGLNLYHTMVKDPSLKSENILFSPVVVATSLGVMSLGAKDKTASQVKSLLRVNLHEDKLHPAFSELFNDVSNETARNTTWKVGSRLYGPTSAELRQEFVEKSRKHYRHDHSKINFRDKRNALKSINEWAAENTGGRLSEITRDLPGSDGAMFVNAMHFKPHWGEAFHHKMVDNRGFLMSKTHSVSVPMMHRTGFYKYYEDEVNQLQIVEMPLGHRQTSMMIIMPFHVEPLERLEKMLTKEQLSVWSNKLQERAVAVSLPKINVDVNHELQKHLQELGLAEAVDKSKADFSGMTGKKDLHLSNFLHATAFDLDTDGNPFDQDIYGREEMRSPKLFYVDHPFIFLIQDKKTNSILLIGRLVKPNGDGNHDEL