lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (Probable). Also has an extraribosomal function, being essential for mitochondrial genome integrity. May interact with MHR1 to take part in the mtDNA repair mechanism.
Miscellaneous:
MISCELLANEOUS: Present with 3400 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MVVKAIARNSIGRNGVGAFVFPCRKITLQFCNWGGSSEGMRKFLTSKRLDKWGQEFPWIQFEVMRKSGHPLLRAEYTNGREKVICVRNLNIDNVENKLKLLKDSDGDILRRRTKNDNVESLNSSVRGIWSPLHAAKRHRI
The following text describes a protein:
Function:
Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTSEYKTWLLGLLRQHGCRRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMTLDKDVPQPAGGGFDAVICLGNSFAHLPDCKGDQSEHRQALKNIASMVRTGGLLVIDHRNYDHILSTGCAPPGKNIYYKSDLTKDVTTSVLTVNNKAHMVTLDYTVQVPAAGQDGPPSLSKFRLSYYPHCLAPFTELLRAAFEGKCQHSVLGDFKPYQPGQAYVPCYFIHVLKRTA
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA (By similarity).
Subcellular Localization:
Mitochondrion.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MLRQVTRACPFCEVRSLLGQAPRSLQPQTRLYTQVQREAQRERGSRDSNTPSRPRDRRTPETDAFPPSSDRGSRGRSPRGRDDRRPSRMILSDAVSRPPQSDQRPARRPQEPFGHLNRTRAPPSLERERERRESHFERPKRNDDGKRRTRAEPYHALKMQRSLHEVPYGNRTTIKRKMELYDSFDKMPLLDTVQAAIKDALPALEYRSPTPAQSVAVPALLGLEAKKRTKATSTKKGGPEAFLLAAETGSGKTLAYLLPTLDAIKKAEQQEKEDAEAQAQKDADEAAAKAQDKRTDIFAAEEPEVNKAVDPARPRAIILVPSAELVAQVGAVAKSLSHTVKFRAAPISAKMSATVIRNQLFNEKGVDVVISTPPLLASIAESNPNILARVTHLICDEADSLFDRSFKPSTTEILERATPSLKQLILCSATIPKYLDKYLADRFPDMNRLVTPNLHAIPRRVQLGVVDVNKDPYHGNKNLACADTIWQIGRSTGEYDPAEGKEAVPTKRILVFVNEREDTEKVAQYLMSKGIDALAFHRDTDPSRQAKTLASFTGSDTSTAIKSSPDAPPKPELASKRTLANTKVIVTTDLGSRGIDTVSVRHVILYDVPHTTIDFIHRLGRTGRMGRRGRGIVLLGPGDRADVVKEVREAMYRGEALI
The following text describes a protein:
Function:
Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MASKGSNTDCMSCSVLNWEQVSRLHEVLTEVVPIHGRGNFPTLKITLKDIVQTVRSRLNEAGIAVHDVRLNGSAAGHVLVKDNGLGCKDLDLIFQVSLPSEAEFQLVRDVVLRSLLNFLPEGVSKLKISPVTLKEAYIQKLVKVSTESDRWSLISLSNKHGRNVELKFVDCIRRQFEFSVDSFQIILDSLLFYYDYSENPMSEHFHPTVIGESMYGDFEAAFDHLQNKLIATKNPEEIRGGGLLKYSNLLVRDFRPMDKDEIKTLERYMCSRFFIDFPDILDQQRKLETYLQNHFSKEERSKYDYLMILRRVVNESTVCLMGHERRQTLNLISLLALKVLAEQNIIPNATTVTCYYQPAPYVSDVNFSNYYLANPPVPYSQSYPTWLPCN
The following text describes a protein:
Function:
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAPSAFLFIVWVLVRCASGSFPLAQNVTWKSTNFKTLLFWQPEPSSDYSYTVEFSAIGQNKQKSPHCIQSSETFCDLTSYLTDLNACYTADVLSGPPRGGTSDLIEFPHTTSPRFCPYRDTEIGRLDFELIRNEDKTSTTLQVTDPLTAVFKDGRQLSIRDIFSDQLQYKVTYWRNQSTGKKVLQSKNSNITLTDLDRGESYCFIIQALIADRSLDNQLGEMSQTKCSKNEKPSIFQVFSLGVIAAGVLLLLLLVGTVVGITLVCYRHRKKALRRQKGLPLQKI
The following text describes a protein:
Function:
Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils. May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity).
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MKLLALLSLLILMLQEARTASLSEEREGDPYAILHLGDYVLSLDNYDEVIDPSNYDELIDYGDQLPQVKGTSLASLTRTRFTQSTEAARTLPSNPTTARPPTLGLLAAPANHGLPTCLICVCLGSSVYCDDADLENIPPLPQTTAYLYARFNRISHIRAGDFKGLTKLKRIDLSGNSISSIDDKALRLLPALRDLILPENKLVALPTLPTSIEVLDVRMNRLQSSGIQPEAFRALEKLQFLYLADNLLDAIPPSLPLSLRSLHLQNNMIETMQRDAFCDAEEHRHTRRPLEDIRLDGNPINLSLFPSAYFCLPRLPTGRFV
The following text describes a protein:
Function:
Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton.
Sequence:
MDENKDPDSKDSGEYEDDFEKDLEWLINEKEKSGASIVEMAGGNEENINQDLKQNETEIEHTEQLSDPNKSLKDEGSLRRNDFISVPSFQPLDPISDSDSENSLQESKLESQQDLEEEEDEEVRRYIMEKIIQANKLLQNEEPVNDKRERKLKFKDKLVDLEVPPLEDTDTGKNHFENESNVSGKLSQLCISNEFGQENVLLSLTDARCEENKDRKILVERDGKFELLNLQDIESQGFLPPINNADSTVENEPQQLSPRSSNSSVSGVKKEEPIMKIHAVAYSSTEEPLAYIPQPPPNPKTYPGSAANSDGSKGNGKSNHRTQSADVSPVTSTYCLSPRQKELQKRLEQKRERLKREEEQRKIKEEKEKKKENDMVFKAWLQKKREQVLEMKRIQRAKQIEDMNSRQEDRDPQLAFQLWLKKKHEEQLKERKTEELRKQEECLFFLKGTEGRERAFKQWLRRKRIEKLAEQQAVKERTRQLRLEAKRSKQLQHHLYTMSEAKSFRFTDHYN
The following text describes a protein:
Function:
Not required for exponential growth; probably functions in vegetatively growing cells, maybe required for accurate translation under stress conditions.
Sequence:
MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDSVELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVEVPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPAGGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ
The following text describes a protein:
Function:
Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (By similarity). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (By similarity). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (By similarity). Required for degradation of gig. Required for genomic stability in the face of endogenous DNA lesions and for the response to MMS-induced DNA damage. Required for normal wing development.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSHHYVVTAQKPTAVVACLTGNFTSPTDLNLIIARNNQVEIDLVTPEGLRPLKEININGTIAVMRHFRPPDSNKDLLFILTRRYNVMILEARMVNDVITVVTKANGNVSDSVGIPSEGGVIAAIDPKARVIGMCLYQGLFTIIPMDKDASELKATNLRMDELNVYDVEFLHGCLNPTVIVIHKDSDGRHVKSHEINLRDKEFMKIAWKQDNVETEATMLIPVPSPIGGVIVIGRESIVYHDGSNYHAVAPLTFRQSTINCYARVSSNGLRYLLGNMDGQLYMLFLGTAETSKGVTVKDIKVEQLGEISIPECITYLDNGFLYIGARHGDSQLVRLNSEAIDGSYVVPVENFTNLAPILDIAVVDLDRQGQGQIITCSGSFKDGSLRIIRIGIGIQEHACIDLPGIKGMWSLKVGVDESPYENTLVLAFVGHTRILTLSGEEVEETEIPGFASDLQTFLCSNVDYDQLIQVTSDSVRLVSSATKALVAEWRPTGDRTIGVVSCNTTQILVASACDIFYIVIEDGSLREQSRRTLAYEVACLDITPLDETQKKSDLVAVGLWTDISAVILSLPDLETIYTEKLSGEIIPRSILMTTFEGIHYLLCALGDGSMYYFIMDQTTGQLTDKKKVTLGTQPTTLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNHMCSLNAQAYPDSLALANKNAVILGTIDEIQKLHIRTVPLGEGPRRIAYQESSQTFAVSTLRIDVHGRGGAKPLRNSASTQAQNITCSSNFLPKPGGGNSTAANAEVGQEIDVHNLLVIDQNTFEVLHAHQFVAPETISSLMSAKLGDDPNTYYVVATSLVIPEEPEPKVGRIIIFHYHENKLTQVAETKVDGTCYALVEFNGKVLAGIGSFVRLYEWTNEKELRMECNIQNMIAALFLKAKGDFILVGDLMRSITLLQHKQMEGIFVEIARDCEPKWMRAVEILDDDTFLGSETNGNLFVCQKDSAATTDEERQLLPELARFHLGDTVNVFRHGSLVMQNVGERTTPINGCVLYGTCNGAIGIVTQIPQDFYDFLHGLEERLKKIIKSVGKIEHTYYRNFQINSKVEPSEGFIDGDLIESFLDLSRDKMRDAVQGLELTLNGERKSADVEDVIKIVEDLTRMH
The following text describes a protein:
Function:
Activates the cell division inhibited by chromosomal DNA over-replication.
Miscellaneous:
MISCELLANEOUS: In vitro, binds double-stranded DNA, but not single-stranded DNA.
Sequence:
MKKPLRQQNRQIISYVPRTEPAPPEHAIKMDSFRDVWMLRGKYVAFVLMGESFLRSPAFTVPESAQRWANQIRQEGEVTE
The following text describes a protein:
Function:
Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene. Plays a role in nucleosome localization of the PRC2 complex.
Subcellular Localization:
Nucleus.
Sequence:
MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEDDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRKQNASPVTILIPKEGHSIVS
The following text describes a protein:
Function:
Lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets. Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology. Sphingosine-1-phosphate export from platelets is required for platelet aggregation and thrombus formation. Mediates the export of different sphingosine-1-phosphate (S1P) species, including S1P(d18:0) (sphinganine 1-phosphate), S1P (d18:1) (sphing-4-enine 1-phosphate) and S1P (d18:2) (sphinga-4E,14Z-dienine-1-phosphate). Release of sphingosine-1-phosphate is facilitated by a proton gradient. In contrast, cations, such as sodium, are not required to drive sphingosine-1-phosphate transport. In addition to export, also able to mediate S1P import. Does not transport lysophosphatidylcholine (LPC).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAAPPAPATEGSPQPEPHVREPGPGSARRGREDSRASRLSFCTKVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSQRTGSGRLMPWVLGCTPFIALAYFFLWFLPPFTSLRGLWYTTFYCLFQGLATFFQVPYTALTMLLTPCPRERDSATAYRMTVEMAGTLMGATVHGLIVSGAHKHHRCEATVTPGPVTVSPNAARLYYIAAAVVAVTYPVCSSLLCLGVKERPDPSTPASGPGLSFLAGLGLTTRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGKKMSAFGISAMVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLQHHHGPGLETIFYSSYVFFTKLSGACALGISTLSLEFSGYKAGACKQAEEVVVTLKVLIGAVPTCMILAGLCILMVGSTPKTPSQDASSRLSLRRRTSYSLA
The following text describes a protein:
Function:
Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
Sequence:
MKYILSLDQGTTSSRAVIFDKNANIKGFAKKEFKQIYPHPSWVEHDPNEIWGSLLGVMAEALANARTFPNNIEAIGITNQRETTIIWDRNTGHPIYNAIVWQDRRTAQLCDELKSKGKDKIFLQKTGLVLDAYFSGTKIKWILDNVAGARKRAEKGELCFGTIDTWIVWNLTKGKIHITDYSNASRTLLLNIKSLKWDCDLLQILDIPKSLLPELKQSSEVYGKTDASALGTEIIISGIAGDQFAATFGQACLQKGMAKNTYGTGCFVTVNIGKKPIINEQKILTSIAWGRKNSITYVFEGSVFIGGAVIQWLRDNLELFRKSGDAEAVAASVDNNGGIYFVPAFVGLGTPHWDPYARGMIIGLTRSSTKEHITRAALESIALQSFDVLTEMQNSIQEFEIKELRVDGGASKNNLLMQFQADILQCNVVRPKITETTALGSAYLAGLAVGYWESAEEITSLWKSDKIFEPSMEKSKREDLIYNWNKAIKRAKAWI
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin Rv2654c.
Sequence:
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLDDEQRRLEAGMKLGWHPYHFPDEPDSKQ
The following text describes a protein:
Function:
Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development; is responsible for the progression of the morphogenetic furrow during eye development. Patterns the wing imaginal disk along its anterior/posterior axis and has a role in positioning pro-veins. Also required to subdivide the wing disk along the proximal/distal axis into body wall (notum) and wing. Ensures the correct architecture of wing epithelial cells. Has multiple roles in the developing tracheal system, controlling directed tracheal cell migration during embryogenesis and later specifying the fate of fusion cells in the tracheal branches. Required for viability of larvae. Essential for the maintenance and division of germline stem cells in the ovary. Signals via the type I receptor tkv, the type II receptor punt, and in some tissues via the type I receptor sax, in a signaling cascade that leads to activation and repression of target genes.
Subcellular Localization:
Secreted. Note=Is internalized by receptor-mediated endocytosis.
Sequence:
MRAWLLLLAVLATFQTIVRVASTEDISQRFIAAIAPVAAHIPLASASGSGSGRSGSRSVGASTSTALAKAFNPFSEPASFSDSDKSHRSKTNKKPSKSDANRQFNEVHKPRTDQLENSKNKSKQLVNKPNHNKMAVKEQRSHHKKSHHHRSHQPKQASASTESHQSSSIESIFVEEPTLVLDREVASINVPANAKAIIAEQGPSTYSKEALIKDKLKPDPSTLVEIEKSLLSLFNMKRPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFTHKDSKIDDRFPHHHRFRLHFDVKSIPADEKLKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRRSADEAHERWQHKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRPTRRKNHDDTCRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGCR
The following text describes a protein:
Function:
Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity).
Sequence:
MHETRIVVGPAPFSVGEEYSWLAARDEDGAVVTFTGKVRNHNLGDSVKALTLEHYPGMTEKALAEIVAKARSRWPLGRVTVIHRVGELWPGDEIVFVGVTSAHRSSAFDAGQFIMDYLKTRAPFWKREATPEGDRWVEARDSDQQLAKRW
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAIADKLLVQRQRHLKWRGLDWLELALMILCGVLCFGFSLSVTADIVTRTIGHPWLWLQEVTSTLFIYAIFVGTAAATRRNDHLYLTAISEAMHGTPRLIVEVIIRLVVLGVAFCLIWYGYQNYLRGFGSFRLPSGTPIASLYAIIPLSGVLIGLFTIEQLVNGLRNGFDHPEPPDEDAAPGLTEAQMRAQP
The following text describes a protein:
Function:
Involved in mitochondrial genome encoded proteins translation.
Subcellular Localization:
Mitochondrion.
Sequence:
MSSSNLSSILRNSRIAQVPKPKGPLFSPDKKYVPTHQLIENKASTMHRQEWGMKSSIPSRSKSRYLIFDELDTQQRLTSFEAIGQYQWNRIRIQELGVVPERATAGNSFQTSADANAPSNPLFSGFSSRLSARTPLSSFFGLTSKSDAKQWKAAEKKVAALRPAFKKWLQDHHPHLIIHKDQMDPADFRKRAVEFITEIATRSSGAGGSWKVVGNGGLTYGLKGRLQQSPLGIKQNTVVEGRILQTNGMEKSVAAAGFVGNGMLGTNLRKVDYAMGDLVRTARFPFEVKQARLLENGRLLMDMSLIEPKNTARKYGYGAKENKNRTYIFQRGAVNERKISSEESAQQAEELLNILTNFEN
The following text describes a protein:
Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
Sequence:
HTGRLGRLFYDIPTIDLAKDLLGKLLYRVLTGGEVVIGRIVETEAYLGRTDKACHSFGGKRTVRNEAMFMEPGTAYVYFIYGMYYCLNISSREEGACVLVRALEPVKGLDTMRKFRGAKHKDKGAGLKEIQLCNGPSKLCQALDINKTNLNKKDLVTSNRFWIEEDDSGGRFKVVTSHRIGIDSYGAEASSQPLRFYVYGCRSVSVRDKKAEAELN
The following text describes a protein:
Function:
Releases the N-terminal proline from various substrates.
Sequence:
MKITEGYMPYLEYKTYYRIVGECTGNKKPLVLLHGGPGSTHNYFEVLDKVAEDGRAVIMYDQLGCGLSATPSRPDLWNAKTWIEELIQLRKHLGLDEIHLLGQSWGGMQAIQYACEYKPEGIKSYILSSTLPAASLWEKEQRRRVAYLPQEMQDAIAKAEKAGDYSSKEYQEAEAEFMLRHCAGAVGPDSPECLRRPKVAGTEAYVTAWGQNEFSPSGTLKNFDFMKEIEDIKEPCLITSGLLDLCSPLVAKTMYDKIPNSEWELFEFSRHMPFVEENEKYIEVLNKWLNKND
The following text describes a protein:
Function:
Bifunctional nuclease with both RNase and DNase activities. Involved in basal defense response. Participates in abscisic acid-derived callose deposition following infection by a necrotrophic pathogen.
Sequence:
MATTLYVSAPCSCTNSAFEFILCSFSSGVVRPFLLVKQRFAACPCQAWSSCRGSLISEVGMTSSASISSGGMISRGKVRGFGAMVGMSDDFHEGRRRFESSKEETHWVLNRRQVLLGSLLTSYPLFVTQGMVALADLTQELESSSSAETQESAEVDTFGFDGLGSREEEYAVGKVVALAQAGDGAVLFLGVDGFDLPLQMVVGAAEAMAILTAAQDRRSRRPVTHEAWGSSLAAVGWKVDHVTITTMESDVFYSRLVLALGKSLDKEAAEVSRNDRFRSVDTRPSDAIALALRCRAPLFINKKVAEEAVGALIKGADPVKRPSDPLNQPGLQAKSAIDTSSNNFLDRFASQAGSNREPLWRSSDNDSYNDIVHNFKPIHWKSRGTLKLYQSTLYV
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
Subcellular Localization:
Nucleus. Note=Localizes to double-strand breaks (DSBs) sites of DNA damage.
Domain:
The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).
Sequence:
MPPVSEVDRGPVEESSGGLKRSDCVCPVCLEIFLEPVTLPCMHTFCKPCFLETVDKSNMCCPLCRKRVSTWARLNSRNKTLVNMELWRRIQDAFPSQCERRVQGIDDDEEAVMIPKPRVCQPGELRKEYEDQISKLVEEKRALEEAERRASEEYIQRLLAEEEERLEEERRRREEQQLENDEKLARLLSLELNSGPASESTCNIKPAEATPAKKKPSVGDIEKFLRPVPHRQPSSSDSSPDSSLMANKENILSPPKPLSALSAEDCGKLTVHMLECNGKPSTSSFNPSTSEHTFVFNTPKSSSVKRKSSEIELQSEVDLHSKRPCALLRFDSSSEDSPFLSEVAVHEEALRSRWQQEEEDRRLALRIQKELDRENSVDRRKGSADSYQLRQKNTSVSTTTSPDVEGTKKGSNTTTAKNCTGRRGEEKTEKRLSGTTPGKRPGVKTPVSSTAVSSTVKKGTKQTTLTEMFPNMGS
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Required for normal cytoskeletal function and when bound to byr1, is involved in the regulation of sexual differentiation.
Subcellular Localization:
Cytoplasm. Note=Localizes to the cell tips and septum forming regions.
Sequence:
MAEGNKAVDLTSLSLEQLSEVIKQLDSELEYLSTSYGQLGRAQLKFRECLANVNDAVRAENDGKEVLVPLTSSLYVPGKLNLGNSKLLVDIGTGYYVEKSAGEATEYYKRKCEYLASSIENLNNAIDAKSVQIRAVQNIMQQKATATTAATKSS
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MASTEKITVYNVADLRATTDDALVNYLNSLGLVQSHTLLDTRLALGFSAFLLSAACFAWDYKFGFESTKQYTLIAVILYTLLNGALTYWIMFVERGTIYVGSTKDGKTRVRLISDSKKPQQKGEAPLYKLRVDVEDVKTGKKEKIELERKFSEWFDASGRFVAAPFQTVLAQRIPLVGKLDPKRAVVAAAPSSEQNVIREQFAETPGYTAEILDAIASGLGESSTTTAATTGSSANQDAGKKRRK
The following text describes a protein:
Function:
Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
Sequence:
MHWRIANEVARIEAKYPNALTAKELYDLLDHFKYIVPQGSPMTGIGNDYQVASLSNCFVIGVDGAADSYGAIIKIDEEQVQLMKRRGGVGHDLSHIRPKGSPVKNSALTSTGLVPFMERYSNSTREVAQDGRRGALMLSVSIKHPDSEAFIDAKMTEGKVTGANVSVKLDDAFMQAAVDEKPYIQQYPIESANPTTTKEIDASTLWKKIVHNAWKSAEPGVLFWDTIIRESVPDCYADLGYKTVSTNPCGEIPLCPYDSCRLLAINLYSYVVNPFKPDAYFDFELFKKHVALAQRIMDDIIDLELEKIERIMEKIDQDPEGEEVKHAERNLWNKIYKKSGQGRRTGVGITAEGDMLAALGLRYGTEEATEFSEKVHKTVALGAYRSSVEMAKERGAFEIYSNEREQNNPFIQRLAEADPELYAEMKKYGRRNIACLTIAPTGTTSLMTQTTSGIEPVFLPVYKRRRKVNPNDTNVHVDFVDETGDAFEEYIVFHHKFVTWMEANGYDPAKRYSQEEIDELVAKSPYYKATSNDVDWLMKVKMQGRIQKWVDHSISVTINLPNDVDEDLVNRLYVEAWKSGCKGCTVYRDGSRSGVLISTKSDKKETLPPCKPPTVVETRPRVLEADVVRFQNNKEKWVAFVGLLDGHPYEIFTGLQDDDEGILLPKSVTSGRIIKNIDEDGTKRYDFQFENKRGYKTTIEGLSEKFNKEYWNYAKLISGVLRYRMPIEQVIKLVGSLQLNSESINTWKNGVERALKKYIQDGTEAKGKKCPNCGNETLVYQEGCLICTTCGASRCG
The following text describes a protein:
Function:
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
DDKKKDAGKSAKKDKDLLNKSGGKAKKKKWSKCKVRDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQELLSKGLIELVSKHSAQVIYTRNTKGGDAPAAGEDA
The following text describes a protein:
Function:
Sialidase is able to release sialic acid from a wide variety of natural substrates including bovine salivary mucin, colominic acid, bovine fetuin, a serum glycoprotein containing both alpha-2-6 and alpha-2-3-linkages in a ratio of about 3:2, and glycoproteins and glycolipids from thermally denatured human lung epithelial cells. Does not show any trans-sialidase activity since it is able to remove terminal sialic acid residues but is unable to catalyze their transfer to the acceptor substrate. 2-keto-3-deoxynononic acid (KDN) is the preferred substrate and A.fumigatus can utilize KDN as a sole carbon source.
Sequence:
MQSMRFMILALLVQFLPAWAINDPAKSAAPYHDEFPLFRSANMASPDKLSTGIGFHSFRIPAVVRTTTGRILAFAEGRRHTNQDFGDINLVYKRTKTTANNGASPSDWEPLREVVGSGAGTWGNPTPVVDDDNTIYLFLSWNGATYSQNGKDVLPDGTVTKKIDSTWEGRRHLYLTESRDDGNTWSKPVDLTKELTPDGWAWDAVGPGNGIRLTTGELVIPAMGRNIIGRGAPGNRTWSVQRLSGAGAEGTIVQTPDGKLYRNDRPSQKGYRMVARGTLEGFGAFAPDAGLPDPACQGSVLRYNSDAPARTIFLNSASGTSRRAMRVRISYDADAKKFNYGRKLEDAKVSGAGHEGGYSSMTKTGDYKIGALVESDFFNDGTGKNSYRAIIWRRFNLSWILNGPNN