lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
RAARVLFFLKTDNPIRQFATTVVEKKYPLTFEYLILFTIFANCVALALYQPLPNNDNTLLNENMEKVEYVFLAIFTIESFLKIITYGFAIPSGAYLRNGWNILDFIIVIVGIINIIFTATSSSNQNIDVLRALRAFRVLRPLRLVSGVPSLQVVMNAIMKAMVPLFHVAALVVFVIIIYATIGLELFNGVLHRACYHNITKKLINDPRPCAASESFESAHHCKSGYVCLRNWTGPNAGITSFDNIGLSMLTVFQCITMEGWTNIMYSINDAVGSEWPWIYFVTLIILGSFFVLNLVLGVLSGEFSKEREKARVSGDFKKLREKRQIEEDYRGYLEWIGKAEDLEVDVDDLQVDMEQQVAGTQNFYIIFLNLNFNFKFSLVFRHQLKRWHKRSRRYCRLVVKSQTFYWLVILAVLLNTICLAVEHYEQQRVVTQFLSITNSVFVGLFTIEMSIKMYALGIEGYFMSLFNRFDFLVVLVSIIELIFIAIIGGAAALGLSVLRCVRLLRIFKITRYWNTLRNLVASLLNSMRSIASLLLLLFLFVLIFALLGMQIFGGRFNFNKSIPRSNFDSFWQSLLTVFQILTGEDWNEIMYNGIKALDGIDRFGILAVFYFIILVVVGNYILLNVFLAIAVDNLANAESLTEINERRNAKRKMAKEQRLQKLQTPVQSLRYGNITEEPARPRLDASFRTNTTQINWKKIPDRVIVPIPKATSMFLFKSTNRFRCKIFDFVTNLYFSNIILIIIILSSITLAAEDPLGKDKIRNQVLSYCDKTFTAIFCVEAAMKMIAFGVIMHEGSYFRNIFNILDMIVIAVSIADYTIAEENLKQLKVLRVLRVLRPLRALNRARGLKHVVQCVFVAIKTIWSIMLVTLLLVFMFAVIGVQLFKGRFYFCTDASKMDNSTCKGSYYNYPTGDLNYLQVEPRIWKESSFNFDNVPNAMMTLFTITTFEGWPSILYRAIDATEAGRGPSRNHQPLVAIYFVIYIIIVAFFMVNIFVGFVIVTFQTEGEQEYRNCDLDKNQRNCIEFALKTKPQKRYIPKNKLQLAVWKLATSLGFEYTIFGLITLNTMTLMMQVYRPSRVYNDVLEYLNIGFTVLFGLEAILKIVAFKPQNYFRDKWNVFDFVIVVGSIIDIVISEIYKVGIELVLKITDSSNVTVDFSVNFFRLFRAMRLVKLLSRGGGMRTLLWTFMKSFQALPYVGLLIVFVFFIYAVIGMQLFGTVLTSPGSAITEYNNFHSFFSSVLVLFRCATGENWQLITLSCTWRTGNGCSENSCGSNISYLYFSSFYVLSSFLVINLFVAVIMDNFDYLTRDISILGPHHLDEFVQAWSFFDPEATGRIKFDDMVKLLRRISPPLGLGKLCPDSTAYRNLMGMHMPLGTDNNVKFNATIFALVRKQLKIKLDGNLDLRDRELRNIIKRIWPRTPNKLLDEILFNFSDNDITIAKIYALLIIRNFIRRRRERQAKQRREQTSNEIQVICLFPK
The following text describes a protein:
Function:
Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Apical cell membrane. Note=Localizes to the apical cell membrane, the basal body and the primary cilium in monociliated node cells.
Sequence:
MSTHFSANQYEKSFDAKRLQNWEVPKHFKEHPSSLEGFTQIISNDRGHILEGIPRSSRSPWGEFVGTWDMTKPPLRTKTLKTKAMTENAQQKRKSASPKQEVARTPSPAKASPRRDSPVQASPRNASPLQGSPKKASAEKVCTPSPKAASVSPVANKSPSPKLATPEPC
The following text describes a protein:
Function:
Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration.
Subcellular Localization:
Nucleus.
Sequence:
MEPQPCLRSLAEGFLAEELRLNNELSQLQFSEPVGIIYNPLEYAWEPHHSYVTRYCRGPKEVLFLGMNPGPFGMAQTGVPFGEVNVVRDWLGIGGTVSTPAQEHPKRPVLGLECPQSEVSGARFWGFFQNLCGQPEVFFRHCFVHNLCPLLFLDPNGRNLTPAELPAKQREQLLRVCDAALFRQGALAGIWKVWKTLADCFPAGEPLLAPPGPLGFLRLGRRRPGPSWARSGSGCAPAAGPGRLGRRRSEGPDPGRALGRRDFVPGLPGAPAQAQFPGFLSRHVPASLGPRRRARSRALPGPRLPPPPPRLATVGLARAGGCSPRGAGPSGFPPGPGGAGLTRPGPQASPGRKEGLCRAADPGEQPRPPPPPARSFAAFFAG
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEIVYTAMLTGTASEDLRKQLLSKTPKTISSLMTTTQIRIRIEDGMREFIMKNRGTSQKQYQDSYGGRADSNRFGGRDAKPRRWRRLWGVYLEICYVSKIRKSVGMISTLFSLVFAEMGVILTLLFRSPLRKLLIVGIDQLKRGRGPLVAKTVAATLLVVFSAVLYSVMEIRRRSMESGVMNSTDEVLMAQRLLEASLMGLTFFKSDKEFVILTKYQIISSRIGELCAPRTN
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MPAVSELEQVTLKEKPLDAGIFIDPAVKNDGVGVEKFLQGKVFFYRWCDWILWKSFKCAVLVEKILRTMPGVAKIYLMIRAKDKEVAKQRLKNEIVDIELFKCLKEAYGEHYEAFMWNKLVPVVENVGDSNLGIYDVALEIKAIGLCNAVRFFVLSSADSVKRDSRQGRFMEEKVRTRDIMGRETFRLVDPVILYYGKGKLTVFPLNPNCVVAIVPADIVVNATLAAMTKHVLLAKKADINIYHLLLLFQNQ
The following text describes a protein:
Function:
Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).
Subcellular Localization:
Cytoplasm.
Sequence:
MNATVDTNAERAALIDRLQGALDALESGDEAAWKREVDHLAALRTRPMMQGLSRLARELGQALGELPTVPEEAGELDDACSRLDHVVEMTEKASHRTLDLVEECRLLANQLRDGGLNQDQGALMDKMRHNLTELSLAQSYQDLSGQIIRRVAGIVRRVHEGFGALGLPPKSTEPKKDDGGLAGPAVKGLDRHAVSQDDADDLLSGLGL
The following text describes a protein:
Function:
Transcriptional regulator involved in several developmental processes during embryonic and imaginal disks development. Involved in determining dorsal cell fate. Acts as an essential transcriptional regulator of proneural achaete-scute complex (AS-C) and is required for its spatial regulation during development of the adult peripheral nervous system, and hence for the positioning of neural precursors. It is the only factor to directly activate AS-C genes.
Subcellular Localization:
Nucleus.
Sequence:
MGILLSDGDSTSDQQSTRDYPHFSGDYQNVTLSAASASTSASASATHVAAVKMYHSSAVAAYTDLAAAGSAASAGVGVGVSGYHQQAVNAPVYVPSNRQYNHVAAHFGSAAAQNAWTTEGFGSAHAQFYSPNAAVMMGSWRSAYDPSGFQRSSPYESAMDFQFGEGRECVNCGAISTPLWRRDGTGHYLCNACGLYHKMNGMNRPLIKPSKRLVSATATRRMGLCCTNCGTRTTTLWRRNNDGEPVCNACGLYYKLHGVNRPLAMRKDGIQTRKRKPKKTGSGSAVGAGTGSGTGSTLEAIKECKEEHDLKPSLSLERHSLSKLHTDMKSGTSSSSTLMGHHSAQQQQQQQQQQQQQQQQQQQQSAHQQCFPLYGQTTTQQQHQQHGHSMTSSSGQAHLSARHLHGAAGTQLYTPGSSSGGGSASAYTSHSAETPALSNGTPSPHYQHHHHLGGTHGHHVTAAAAHHHFHAAAAVAAYGVKTEASATNYDYVNNCYFGGTFGALGGAATTTAMAGGAASELAGYHHQHNVIQAAKLMATS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MENDPSVGSFIPAMYDILKCLEKEPHDLTVKINELKSQLQKTREMVEQLQGVDLSKDLQLRQMEILRQQLNAKTDLLRKYKNSCYFDVPK
The following text describes a protein:
Function:
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRVLILLLMLLLPGLSQAQPGDDLFAPRGATQTDFLPVEKAFRFTWERLDDGQVQLRWQIAPGYYLYQKRLRFDGLDPALQPQLPPGESHSDEFFGESQVYRQSLELTLPAAAAGQLRLGWQGCADAGLCYPPQSQALDLGGTGPAAAGTSGEVAEDQGLAGSLQAGNLAWSLLLFFGLGLLLAFAPCSLPMLPILAGLVVGSGAGPRRGLLLAGSYVLSMALVYAGLGVVAALLGGNLQAWLQQPWLLGSFAALFVFLALPMFGFFELQLPAALRDRLDGLSRGRKGGSLAGAAALGALSGLLVGPCMTAPLAGALLYIAQTGNALHGGLVLFSLGLGIGMPLLLLVTVGSRFLPKPGPWMNLVKGVFGFLFLGTAWILLRPLLGEALWIGLGGALLLVLAYAALHTARGLARHAVLFGAAGCIFGLWGAAMLLGAAAGADDPWRPLQVYAAANRGATPTASAHEAFLTVSQPAELDRQLAAAKAEGQWVLLDYYADWCVSCRIMEKQVFAKPDVLAALQGVRLLRLDVTADNAASRELLHRYQVPGPPSLIWIGPEGEERRARRLTGEVDAGGFLAHWQATRERG
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MDYSDDDSAGYDSTEDYNDDGKNFTILDEAEIRRRQNEAISHISSLLSLSNDEASILLYHYNWKTEKLHEDWFADEDSVRNKVGLLINNSDGDTDNCNNCEICYDDLNTVKSMSASCGHRYCVTCWESYITVAINNRGAGCLSLQCPAIKCNAAVTRDLIVKLVSDEDVGKYDRYFIRSYVECRVKTTKWCPSPGCDNAVEFEDSGVGGSGGGGGGGGYDVSCVCSHEFCWNCVEEPHRPVDCELLAKWILKNSSEAENTKWILAFSKPCPKCKRPIEKNLGCNHMSCREPCRYQFCWLCLGDWGKHSECNRYAAENNMDEKMRKNAKDSLQRYSHYYERWASNHKSRQKAIEDLQKVQTIDLNRLSDRVNTPTTQLEFIVQAWKQIIECRRILKWTYAYGFYMAEDKKTVQKKELFEFLQGQAEAQLEKLHGCAEIELSGFLVDDVDDNGNNTNNNKNNPDYYSDELEFSMYRSKLSGLTKVAGKHFEELLKALEDGLSEVVVQKRGKKYNTTMNNNKKKKKDSSSSSSYSQPQQLLGQTFEQLRRPFGQPQQHRQQPFEFDDAIDDDDVDVDVDDDDDDDDVNVNVNVNVNVDVWSCDRCTFRNPGSATSCQMCVGN
The following text describes a protein:
Function:
Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MGEPWAARGTEGAPARMPVVFTALWAAVVVLELTYVMVLGPGPPPLEPLARALQLALAAYQLLNLLGNMGLFLRSDPSIRGVMLAGRGLGQGWAYCYQCQSQVPPRSGHCSACRVCILRRDHHCRLLGRCVGFHNYRPFLCLLLHAAGVLLHISVLLSPALSALLQAHSALYTVALLLLPWLMLLTGKVSLAQFALAFVVDTCVAGALLCGAGLLFHGMLLLRGQTTWEWARGQHSYDLGMSHNLQAALGPRWALVWFWPFLASPLPGDGITFQTPTDVGLVTS
The following text describes a protein:
Function:
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
Sequence:
MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
The following text describes a protein:
Function:
With IRS4, acts as a positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates signaling through the cell integrity pathway, including the MAP kinase SLT2.
Miscellaneous:
MISCELLANEOUS: Present with 396 molecules/cell in log phase SD medium.
Sequence:
MHFPKKKHSGNLSVVELPKEALQDSLTAAQITFKRYAHPNGNAGSAERPRHLKVESAPVVKSEPSLPRMRQPEPRSINHQYSRETLPGHSEAFSVPTTPLQTIHYDVRNKASNSPSSIAAAETAAYLAHTNSFSNRSSGVGSRDPVMDTETKPPRAPSALKNELQLNRMRIPPPSYDNNVRSRSISPQVSYSTSLSSSCSISSDGEETSYREKSTDEAFPPEPSMSSYSLASKASAKASLTDPSQRQQESDYTAMNKLNGGNIIYKGTLPDLIPRSQRKTSKPRFKHRLLRSPEQQQENLSRVYSDQTQNGRAIINTQQNVKLKTTMRRGKYAITDNDETFPYDRKSVSSDSDTDEDSNVMEIKDKKKKSRRSKIKKGLKTTAAVVGSSTSVLPFPHHHHHHHQLHNPNSHHLHTHHHTSSHKFNEDKPWKSHRDLGFITEQERKRYESMWVSNRYSYLRLLPWWPSLANEDDESHLQPLNLPQDGLMLNLVVKDIWYRSNLPRDLLVQIYNMVDTRKDGTLDRKSFIVGMWLVDQCLYGRKLTNELDQRVWNSVDGYVLGTINVKPATSDHYHNANNPLDKPSKLSVRQELKNIKRDLRNVRI
The following text describes a protein:
Function:
This enzyme decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into viral progeny DNA. This activity is sufficient to exclude uracil from the DNA during phage replication. In the case of dUTPase mutant phages, the host dUTPase activity is not sufficient to exclude uracil from T5 DNA and uracil are incorporated, leading to decreased phage viability.
Sequence:
MIKIKLTHPDCMPKIGSEDAAGMDLRAFFGTNPAADLRAIAPGKSLMIDTGVAVEIPRGWFGLVVPRSSLGKRHLMIANTAGVIDSDYRGTIKMNLYNYGSEMQTLENFERLCQLVVLPHYSTHNFKIVDELEETIRGEGGFGSSGSK
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MEASSLVAERPTGGEQDPGHARCAFYLPRKRRSCGMAPKAGARFCAEHQPGDSGTAARVPCPLDPRHTVAKAQLRSHLARCNRTKQDQALRAEREHMPWYEAGVNSAARPAAAAADEATLQAAVMRAIPVLAQIAEAEFRAPLRVAVLSNAQVEHVRFPQLPSNRKHALQQSSLIQHLREAGLWVAPERPVAYVEFGCGRGELSRYINQAAVLEQLERGGPAAPPAFVLVDRACPRMKFDSKFAEDVAELHARFCPSVPPDERPAPAVTRKKIDIRDLRLAALLSPGLEHIAVSKHLCGVATDLTLRCLAAGPRASLCGALIAMCCRHACNPAEYANPAYVEALLARHAPDMSYDLFFLALMKMASWAVSGRRPGVPDTEVGGHFSGLAIAERERLGHLARRLVDEGRRQYFADLGYDAELLVYCERDTSREDIALLVRRPA
The following text describes a protein:
Function:
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or grb2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Sequence:
MEDIKKCGYLRKQKSMRKRYFVLRCPGTRGPARLEYYENEKKFRVAEGSGGPRGVLNLEEAFGVNKRSDAKKRHLLVIYTRDGGLGVSADGEEEQDEWYQAILEVQAQARALSSSPDAPAWPGPAFREVWQVSVRPRGLGQTRNLSGIYRLCLAERTLGLLRLRSENPSVTLQLMNVRRCGHSDNYFFVEVGRSAVTGPGELWMQVEDSVVAQNMHETILEAMKSLSEEFRPRTKSQSLSSTPISVPSRRHHPNPPPPSQVGISRRSRAETPIENSPVPKPHSLSKDYSVQSPEEEEEEKGARVETNESSADYGSASSDEYGSSPGVLEAPVFLPPSPGPRETNYISMALYGRRSLVMEPISTNANVPAEEGSRLTLFQEEDNYAMMGQREPRQETGYMPMLPGSNRSQDYMPMTPTSISPPAPVEMAGYVMMSPLGSCSPEIERLSWPPSQEVSAGSSDSHASDYMNMWSLSRSASSTPPPQEAFLSSPGGPCRVPASYRSLPRSYKMEPQPSARASCSSSSDSLEEVNAGKNRRPLSISIDSWNTGTLSGNYRRPPSPGEYVSIHFRAPPEEDLREGSHRCPKRVRFHGGAALGDAQRGLHGNGLCASQNFTTSCKNERGTGNERGKCLQTCGEITAGLGEDFLGEGLLGCR
The following text describes a protein:
Function:
Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors (By similarity). Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins (By similarity). Promotes adipocyte and cardiomyocyte differentiation.
Miscellaneous:
MISCELLANEOUS: 'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.
Subcellular Localization:
Nucleus speckle. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cell projection, cilium, flagellum. Nucleus. Cytoplasm.
Sequence:
MPLFGSIFSPKKTPPRKSASLSNLHSLDRSTRELELGLDYGTPTMNLAGQSLKFENGQWVADSVISGGVDRRETQRLRKRNQQLEEENNLLRLKVDILLDMLSETTAESHLKDKELDELKVTNRRRK
The following text describes a protein:
Function:
Cysteine protease that acts as a key streptococcal virulence factor by cleaving host proteins involved in immune response. Triggers inflammation by mediating cleavage of host proteins, which can both promote host pathogenesis by triggering sterile inflammation and/or restrict streptococcal infection, depending on host immune statue and infection site. Cleaves host gasdermin-A (GSDMA) in epithelial cells, promoting GSDMA activation and formation of gasdermin pores, triggering pyroptosis. Pyroptosis triggers the elimination of the infected skin cell, depriving the pathogen of its protective niche, while inducing an inflammatory response. This ultimately prevents bacterial penetration of the epithelial barrier and a subsequent systemic dissemination of the pathogen. Also mediates cleavage of the cytokine precursor interleukin-1 beta (IL1B) to its mature form, resulting in inflammation and septic shock. SpeB-mediated maturation of IL1B plays a dual role depending on infection site: while IL1B inflammatory response prevents bacterial growth during invasive skin infections, it promotes streptococcal infection of the nasopharynx by disrupting colonization resistance mediated by the microbiota. Inhibits host autophagy be catalyzing cleavage and inactivation of key autophagy factors, such as CALCOCO2, NBR1 and SQSTM1. Cleaves and inhibits a number of complement factors, such as C2, C3-beta chain of C3, C4, C5 or SERPING1, thereby promoting evasion of host immunity. May also impair adaptive immunity by catalyzing cleavage and degradation of host immunoglobulins to promote immune system evasion; the relevance of this activity is however unsure in vivo. Catalyzes maturation and release of the peptide hormone bradykinin from the precursor Kininogen-1 (KNG1) to produce hypotension during septic shock. Also involved in bacterial translocation across the host epithelial barrier by mediating cleavage and degradation of host epithelial junction proteins, such as CDH1 and OCLN. Additionally, has been involved in degradation of fibronectin and vitronectin, two host extracellular matrix proteins involved in tissue integrity. Also able to catalyze cleavage and degradation of streptococcal proteins, such as C5a peptidase, EndoS or SmeZ. Degradation of streptococcal proteins is however strictly regulated to preserve integrity of other virulence factors.
Subcellular Localization:
Secreted. Host extracellular space. Host cytoplasm.
Domain:
The C-terminal active site loop is required for the recognition and recruitment of substrates and release of hydrolyzed products.
Sequence:
MNKKKLGIRLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARSAEDIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP
The following text describes a protein:
Function:
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
MAYQLYRNTALGNSLQVILLQFDKAINSALAQRVRNRVNFRSFLNMYRFCDNLWTFVLNDIEFREVTKFIKVDEAKIVDCDGKNTGSNTTE
The following text describes a protein:
Function:
May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus (By similarity).
Sequence:
MKTTILLMFLWGLSCALPVARYQNTESKSSEEWKGHLAQTPTPPLESSESSEESKLSSEEQANEDPSDSTESEEVLGLDDQQHVHRPAGGLSRRGGSEGDNKDDDEDESGDDTFGDDDGGPGPEERRSGGDSRLGSDEDSADTTRSREDSTPQGDEGARDTTSESRDLDREDEGNSRPEGGDSTPDSDSEEHWVGGGSEGDSSHGDGSEFDDEGMQSDDPGAYRSERGNSRISDAGLKSTQSKGDDEEQASTQDSHESPAAAYPRRKFFRKSRLPEEDGRGELDDSRTIEVMSDSTENPDSKEAGLGQSREHSKSESRQESEENRSPEDSQDVQDPSSESSQEVDLPSQENSSESQEEALHESRGDNPDNATSHSREHQADSESSEEDVLDKPSDSESTSTEEQADSESHESLRSSEESPESTEEQNSSSQEGAQTQSRSQESPSEEDDGSDSQDSSRSKEDSNSTESVSSSEEEAQTKNTEVESRKLTVDAYHNKPIGDQDDNDCQDGY
The following text describes a protein:
Function:
Metalloprotease involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Plays a role in thermotolerance probably by preventing the accumulation of oxidized lipoproteins and cholesterol.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Domain:
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence:
MTKWSPNGNPLSTIYLILSLFTLAHTAPTTQHSRTTTQLRLEDEDGGGGVDEDSIHFVKGQMEKYGYLKGIDHSSPQEFRQALMFFQEVLEVEQTGNVDEMTVEAASKPRCTQTDVRQEQTKRTKRFTLSKRAKWAHASGQSVTLKWYISDYTSDIDRLETRKVVEKAFKLWSSQSYIKNEKKVTLTFQEASSKDEADINILWAEGNHGDEHDFDGANGKIEGNKKENVLAHTFFPGYARPLNGDIHFDDAEDWEIDVDQVGHGSNKRFFPYVLAHEIGHALGLDHSQKADALMHPYYKNVPINEIQLDIDDKCGVIWNYGGASDFCLYVWLMSQIVEAHNSSAQNNHGVGSITSSRTNKKSFKSEGFFLFQLKFPHSTLTHTDDVVMREKDKRSYRGDSKIPKCSSNNSSQRTLAEKKLTLGLHLSEADAKRYTEMVCNFLAGLHMWRTNPNHHASESLEKEYKGVSQEMGTFSGKSIAVRRLIRHAEHQKERSEKGPLDPDYFDDDFFENFFMEYSK
The following text describes a protein:
Function:
Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.
Subcellular Localization:
Cell membrane. Cytoplasm. Endomembrane system; Peripheral membrane protein.
Sequence:
MSIKGTPRGSEETLTASSDSFWDVGNYKRTVKRVDDGSKLCDEFMKMVTERAEIEARYSAKLKVWAKKWEEVIKAGSEYGSMEEAFKGAVDEANSRASVHTQCRDDLLNDVVELVKKWKGDNYQKSMFQWKQVKEAEEGFARAQKPWAKLLMKVMRSRKAYHNAAKATEQAKKLQIEASSDPNVPQEKFKKLTDAVEKARRDMQKCEDKYNDRLENISKDNPRYERDMTEQFERCQAFEQKRKDFFKDALMKYHSCLDVSRKSEFSGIFLHMSTTFQMADSSKDLDYWSRLHGVAMPKNWPRFEELPSELNRRPYDEDLHGSMRRGTGSYENAALEYSAPSYNQVQAAPQQYNDAEQSNPFSHQDSTEEDEFGAIPPPMDDLAVPVLALYDYEAAEDDELSFKAGEIVTKLSERDDQGWCRGRINHRTGLFPAEYVEAL
The following text describes a protein:
Function:
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
Subcellular Localization:
Peroxisome.
Sequence:
MMFERMLDDEIPSGSSSNSRNSMAKDEDMSDDETRKMTLDNESEEVPSKKRRFSYANGVEKSEDEVRGEPLDSSINSFEIPQYEDRKLIGKDLRPLRGGISRSSFIRGSQSTNSLEKLISSDEEMHRIKMENVLKELNLLRWSNDKIVDMDILNRDLLSKFRNPLEWNALEVQLLLDQFDVMQPLKDYVKEQRIKKIASDDSMVFNPPPFQTEKMKCVLRFFDVPVRLGFRHGAISHRLIMYSSSSPGASLDEWRKKSTFDGGKMRSILQGGEDKLKLKDEIWGILEKDPLFKKPNGQLGLEEVRALTHQRWKKIIEYGFVCDPYAEYEKFSALLEVLEEYDTALQARVTLHSNVFMGALTSMGTERHAKLIEKGNRNEIVGCFALTELTHGSNTQNIQTTATYENGQLVFRTPHIGAMKVWSGNLAQSATHAVVFAQLHIGAKCEGVHGFVIQVRDETNHRTLPGIKIGDMGEKPGQWNAVENGWMIFEDYRCSTDALLNRGCDITKDGEYVHSFKSDRDKKSVSLGALSIGRIGIVGKGINACRAAATIGIRYSAVRKQFGPPNEDELPILCYPLQRRRLLPSLAAAISIGFFQDKMVDLFAQYMARVLSGEKSDELAETSKEVHGLSSCCKPRATWLGVAALAEARAACGGHGFLYISRLNELRDTYDPSQTFEGENNILVQQASNYLLSQKKQGILSSPMGSTDFLLSRPSNFGGWKEDTLENVFSAYEWLLHYTLNKTEKALEERKKNGDDQFTARNETQIDTAHPLALAYAELTMIRWANEAVEDIEDEKCKCVLRRVIRLFALSQLQSHLALLYIGGYCTDSEFGTRVKDEQLSLEVSLSSECVSLVDALAPPDFALASALGASDGRAYDHMVDDFRSREIDRAPFADDLVRVRNLVTLSMNTPRVSRPSSRSSTSFDSIAYANSSTTTMSISVMPSHATGVADIAVIGLAVMGQNLILNMNDHGFVVCAYNRTTSKVDEFLANEAKGTKIVGAHSIEEMCKLLKRPRRIVILVKAGAPVQAMIDSIVPFLEAGDIIIDSGNSEYTDSNRRTKELAAKGIHFVGTGISGGEEGARYGPSIMPGGNPAAWPHIKEIFQAVSAKSDGQPCCEWVGEAGSGHFVKMVHNGIEYGDMQLIAEAYHLLKDAVGLNHDQMADVMDEWNKGELDSFLIEITANILRFKDEKGETLLPKIRDAAGQKGTGKWTCFASLEYGIPVTLIGEAVFARCLSALKDERVRASKELPQSDVDPSTLIKDKKEFIKAIQQALYASKIASYAQGFMLLAEASKQFGWNLNYGAIALMWRGGCIIRSRFLGDIKKAFDSNPNLANLLLDNFFKDAVAKAHKAWRTVVSVAVLLEIPVPALSTALAFFDGYKRETLPANLIQAQRDYFGAHTYELTAAPGKWHHTNWTGKGGRVTSNAYQA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MMAALESGLPPSSREMTKVALKPAQSLVTFEDVAVYFTTGEGALLKPNQKALYLEVMMENYGNVASLGFSGPKPELISQMEQGEELWIPDSQMKGDAETFSIDSGGVLGKAWRPPCSERYVVAPQRFPSEKKPFSRLAFGKPSSQQPNLKMPQKTHKGQRSYKCLECGESFKRHSLFVRHWRVHTGENPYECQECGRSYLRPSALVKHRRVHSIKEPKNVCLECGKHFAREAYLLAHQVTHVRDRPRKCLQCGEDFANHPSYLKHQKNHKGKKSYKCLECGECFADRYHVVVHQKVHTELNRFKCSECGECFDQHSALVSHWMVHTGEQPYECLECGKGFPRPSALVKHSRVHSTKKPKNVCLECGKHFAREVNLLAHQVTHVRDRRRKCLQCGEDFANYLAYLRHQKIHKKKRSYKCLECGECFEYRYHMVVHQKVHMETNPFKCSECGECFDEHSALVSHWMVHTGEQPYECRECGKGFPRPSELVLHCRVHTEKESYTCS