lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the retromer complex which acts in conjunction with wingless (wg) and clathrin-mediated endocytosis to sustain a wntless (wls) traffic loop. This loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, thereby enabling wls to direct wg secretion. The hh and dpp signaling pathways do not require the retromer complex suggesting that it does not play a general role in exocytosis.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MNFLGFGQSADIEIVFDGAEHKTAEVKGEDGKVEKMLLFYDGETVSGKVNVTLKKPGSKLEHQGIKIEFIGQIELYYDRGNHHEFKCLAKALARPGDLIQNNSYPFDFPKVEKQFEVYAGSNVRLRYFLRATIVRRISDITKEVDIAVHTLCSYPEMNNPIKMEVGIEDCLHIEFEYNKSKYHLRDTIIGKIYFLLVRIKIKHMEIAIIKKESTGTGPTMFNENETIAKYEIMDGAPVKGESIPIRVFLAGYNLTPTMRDINKKFSVKYFLNLVLMDTEDRRYFKQQEITLWRKADKPRYHGAQQHQQQQHQHVPLHAPPHLVSGPAAPTVAHSLISSSTDSGEVGGAPTAPGTAGSESKMGLFTRESPNQEFSQQQMDSPPLTPTPSTASVAVAVPTAASSVSEPAPERGIGDGAAAATTSASPVAMLSSSPPPLLPVSPLSRSETEASEQVQPEDEDLDAITPNTKKTGATPLATD
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MLQENQRENEKKQYSMFYPEDERSKSHFLNQQYLTNFFEFTNHYKEPDLQNQGKQEEKNQHKIPIIIQYEQEPRYVNQKQQSNLLIPRYRRIMIRRIKRAQQALKLEELRTKQATKVLDKSNQKYIYESRHQHALKRERGPDGKFLKKQNSVDSPSKL
The following text describes a protein:
Function:
Essential for normal spermatogenesis.
Sequence:
MDVEIQDTPGKISISKRSILSGTVENIDYPHYCDLLRKMNMPFVKGLENRHNYGRFEKKCNPAFLKFHPYPPSVLPDYHLHDPYPPPYGPHYPLFPLRDDVTLGDSCSGFMSPGGDADLNPGIGRTIPTLVDFSDVKPQHRVPRPDTGFQTTIKRQKILSEELQQNRRWNSREVPDISIRARLGGWTSPLKVTPLQPHHEGRSLSHIFTFDEEATCTDEGEPLVQTNKKCNAKDSFYKSSTQKAYEDVPWDKMLPPKLVPEETTLEKTADPISQCFTLKRYKGVPAITQMVGELWDRFQTRSFLAPVKPINFVSSSSRSKYIPLYTGHVQSTNADDVDNPLGDIASLAKQRYSKPLYTNTSRAANIPGYTGKVHFTATHPANSNIPSTTPSPDSELHRVFQKEMAVDLFRHQAPLSRLVTTVRPYNPFNKKDKETIDY
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity. Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7. Plays an essential role in TLR4-mediated activation of MAPK pathways by promoting 'Lys-48'-linked polyubiquitination of the phosphatase DUSP1/MKP1 (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MGSLLSPEANAEVPREALSFHGNATGAQVHLDDQRSTARRRSTFHDGIVFSQRPVWPGERVALRVLRHEEGWCGGLRVGFTRLDPAQVAASCLPPFVCPDLEEQSPTWAALLPEGFVRAGNVVCFWVNRRGWLFAKVNAGRPLLLRKDVLVQGAPLWAVMDVYGTTKAIELLDPKANAWIRSGEPVPESEVISGEECVICFHNTANTRLMPCGHSHFCGSCAWHIFKDTARCPICRWQIEEVAVVSSLKAEEGS
The following text describes a protein:
Function:
Replaces the SCC1 mitosis-specific cohesin to ensure sister chromatid cohesion during meiosis. Is cleaved by ESP1 shortly before the first meiotic division, and dissociates from chromatin, allowing sister chromatids to segregate. Is protected from cleavage by SPO13. Promotes localization of the LINC complex subunit MPS3 on nuclear envelope in mitotic cells.
Subcellular Localization:
Nucleus. Chromosome. Chromosome, centromere. Note=Localizes at chromosome cores during pachytene. Disappears from chromosome arms shortly before the first meiotic division, but persists in the vincinity of centromeres until the onset of anaphase II.
Sequence:
MAPLSLNFKDDKKYKGLTTVWLLSALGNSIVKESNNYYSNKSNSTGNISSSTVKKKDIVNISIPKTCDEIQNFENDFSLRYISNLLYGVTICYNKKTEYVLNDLNHLLVQLQKNDVYAFKAKNKSTRINGLNSNNSIIGNKNNNYTWEECVFFDDDPLYDITKVPALEFLNTTLQDNVSFIEEAKSIRRQDYINELSNSNRFELHGDMTNSDAQSNLGSNVRNSFPLDEIPVDVDFNLDLDDIVSHQGTPLGSHSSSQKDGNDFKFNYQGDELVLNFENDNENNSNGGEDTSVENEGPVANLKDYELGLEAQASEEENDLQQKLNTRMQRGHRADVGGQFSKVQFDAKTSYPNEVLKFNHGNYSHLMEKNRIRKLTGQNFLTSNISSLVRSCGEEEFFSTNWLSIFNDFSNIKTSEWDLYPQGFSSVERGRKRAHSLVSTQSSSSTRSHEYGRKSFRNNKNDNYSSDMENDNLLLNLEQINEDLEDGHYIEENSQGNILDFNLNLPPSSFGRSHTRNSTRSSGFNEDIVGALRRRVGPSEQNFAEEDDSSNSCFSDGSQQNLQQDKTNFQDVILDYQTKKFYDYIKERSIVVGRTTRSNPPFKRKMLLVDIIPSRMGEAQTGANFDDVERGVSRQIAASAFLSLLNLATKGMVKLNEYPVADAVTKDLKLRREDEIIVYA
The following text describes a protein:
Function:
Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (Probable).
Sequence:
MKMPASMEPDWKALLRVLRAHSATFYLGSLLFPKEARKGAWAVYAACRLGDEAVDGEGGGPEALEAWWAGVERAYRGRPLAEWEKGLAWALERWDIPFEAFLHMREGFLTDLGPVRLGTEAELLRYCYQVAGTVGRMMAPIAGGGKEAEARAVKLGQAMQLTNILRDVGEDLERDRVYLPLDLLRAHGVEVEDLRAGRVTPGYRALMAHLEGKARALYREGLAGLGHLKVGRAAIALAALQYRGILDKLRLSGYDNLGRRAHLKAWERALLLPKAFLAARFPPRPEGSP
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.
Subcellular Localization:
Cytoplasm.
Domain:
The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.
Sequence:
MINDIKWVQAQRKATDWRQAVEIATRPLVAYGAAQPCYVNGIIENTLNWGPYYLIAPGIALPHARPEQGANYNQVSITTLRTPVAFGNEECDPVWLLLCVSATDANAHILTIQRISQFIDSPQRLTAVGNASTDDALFALVSG
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNDPDNPDLSNDDSAWRELTLTAQDSDFFDRDTSNILSDFGWNLHHSSDHPHSLRFDSDLTQTTGVKPTTVTSSCSSSAAVSVAVTSTNNNPSATSSSSEDPAENSTASAEKTPPPETPVKEKKKAQKRIRQPRFAFMTKSDVDNLEDGYRWRKYGQKAVKNSPFPRSYYRCTNSRCTVKKRVERSSDDPSIVITTYEGQHCHQTIGFPRGGILTAHDPHSFTSHHHLPPPLPNPYYYQELLHQLHRDNNAPSPRLPRPTTEDTPAVSTPSEEGLLGDIVPQTMRNP
The following text describes a protein:
Function:
Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7.
Subcellular Localization:
Cell junction, adherens junction. Cell membrane; Multi-pass membrane protein. Cytoplasm.
Sequence:
MRTNQLMKYTLFVSCYLFWVASGLMIAVGLYAKLSKESSAVDTLLAEPSLLIIVVGVLTFGITFVGCTGALRDVPVLLKMFAGVLLVILILQIVAAVVAFLFSSLVMDKAAFLMEKAIINYRDDLDLQNLIDYIQKKFECCGVHSYTDWSQNVYFDCRVSNPSLERCAVPFSCCIWEKKGILNTMCGYGTQNLKAWKAEDLIHTEGCLEKIVTWDCCALFSCDVNLPDQLHHSEKEQHKERTWTVKGRTLIEPLTLLSKRETNTNPGKKCN
The following text describes a protein:
Function:
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPSLLSAMLLRLFNWFLFAAELARLVTRLAYTLAECAFRLLVPKQKKNVANSVVVVTGAARGLGREIARIFAELGAKVVLLDIDQARNNETAKSIRSDGGKGFSFTCDVTDEDQVKKVAQKIGRLIGEVDILVNNAGIAQSMPILNMNPNQIRRTMEVNTLSHFWTIQEFLPKMLERRKGHIVAVSSMAGLIGAANYTEYCASKFAIMGLMLSLERELAQSDEGRNIRLSTVCPAILSKGFECTGLPFLSTWFPSIFPSMDVQVAAQEVVTRILREEDVIILPASFSLMHRLSLLLPHKVGRLVQEYLDYMVFFIRSGLSKSGTPGVGLQCPRSPPLVSEGTAPQSRNWSCVVSAGSSLQAPEP
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
KKYSMAKQKKGLSDKVRKSKQQKKSSNTLDKVRKNPFEIKINKQKHNILGRKTKNDRGLPGVSRSKANKKRKDTLLNEYKHRNKTNQIRDARFGLNDEQMTIEEKMLQRFSMERKKKHEKMAQFNLNDDEELTHLGQSLSAIKQFDDFDGSDEEDGPGGTMSGEYVENAHFGGGFFTKKSSEGNDNELTKTRKEVIDDIIAKSKLAKFEKKAAREKSDELREKLDDAWSDFQKLIQPSVRTSQDKNTAKERSKPDEYDMAVKQMLFDRKAAPSEKMKSEAELEEERAALLWKQEEERIARMRMDGGNEDASRKRTHQSADALEEDYVVEKVNQAEPLSFNFDDEDEKSEDYVGENEEEEEDAPEDQVESELGDLGIVDDGGDSDDENDEDQSDEFSDIDSGNEEDVSSLEEQPDVVEDVVNKAEEEEDVGQNLPHFPVPASYSEFSFLISSSALSASEVVSDLRKRFAPSIGKGNKAKMIELFAYIWQHCCMVAAPKPDFNIINSLISHAYELCALNPENCSECVKERLKRSYLSCVQASRIQLPSFEILIQFKLIKLLYSTSDFCHPVVTPALLFISHLLDCCSVHTLRDVSKGLYLCTVAYEYVSFSKRYIPECLNFLTTVLCMAVPDKQNKADIPTITSTRINGKNFDILVVKKKNKFKENQLKPDLSVMMDENNDINDTALVRCQLVATATRLTALFSTLYSEVPAYDEVFTKIHSVCDKLKTSFDRSNLVLAKLVDGVLKSIESNCQKPRTPISFGQRKPKPLRMFDLKIDDTGDPLRKKSKQTNALKRERDRLLHKRKREMKGAIREVRKDSKFIARHQQKEQEAMDAEREAKVKRLYGLLSNQEGEVKNIQRKKYKLDI
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MEHVKGNGRQHNAEETSTSRAEENVKGSNISFRSKDPPEQPRAEAVPSEFATIRPGLAADLKFGGSGSYPNLPWVSTTGPGPNGRTISGVTYRYNPTQIRIVCACHGSHMSPEEFVRHASEEQTSQEGGAGVSSFPSSNPAASAQS
The following text describes a protein:
Function:
Dioxygenase; part of the gene cluster that mediates the biosynthesis of fumonisins B1 (FB1), B2 (FB2), B3 (FB3), and B4 (FB4), which are carcinogenic mycotoxins. Within the pathway, FUM3 performs the C-5 hydroxylation present in FB1 and FB2 and which occurs late in the biosynthesis. The biosynthesis starts with the FUM1-catalyzed carbon chain assembly from one molecule of acetyl-CoA, eight molecules of malonyl-CoA, and two molecules of methionine (in S-adenosyl form). The C18 polyketide chain is released from the enzyme by a nucleophilic attack of a carbanion, which is derived from R-carbon of alanine by decarboxylation, on the carbonyl carbon of polyketide acyl chain. This step is catalyzed by the pyridoxal 5'-phosphate-dependent aminoacyl transferase FUM8. The resultant 3-keto intermediate is then stereospecifically reduced to a 3-hydroxyl product by reductase FUM13. Subsequent oxidations at C-10 by the cytochrome P450 monooxygenase FUM2, C-14 and C-15 by FUM6, FUM12 or FUM15, tricarballylic esterification of the hydroxyl groups on C-14 and C-15 by acyltransferase FUM14, and C-5 hydroxylation by 2-keto-glutarate-dependent dioxygenase FUM3 furnish the biosynthesis of fumonisins. The tricarballylic moieties are most likely derived from the citric acid cycle, and their addition to the carbon backbone may involve FUM7, FUM10, FUM11 and FUM14 (Probable).
Sequence:
MNKEKVPQNAVPNGRTKLRQVTSATPLDEVFQYWEEDGAIVIKGLLTSAQVEQLNQEMGPILQKVAIGGHASDVRLQNFHGMKTKRAGDLTNNSAVFRDHLLDNDFIHAVSQRCFAYRGKMGPDAYWLGSASTIHVGPGQKPQTLHRDLGSYPIFWMLGPQGPESQINFLVATTDFTEANGATRIIPGSHKWEFNQHGDRDMTIPAEMKAGDCLLISGKVIHGTGGNKTDQERGCLAVTMCANFLAPEEAHPFIVSMGTAKKLPVRSQRCLGFRSQWPQSSPGLWTKDYSELALHLGLDD
The following text describes a protein:
Function:
Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MHPQVQEERFKSCEPLIMALDECHREDFVPRAFGLCNDVKQQLTLCLRAARIEHASQNRAKATEKQKLFAEKTRRMDEEAYGPNKILLDILAREKDGKSSLPRYEAPVIAAPVEQSE
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGFLKDRVGGQHPEVLARYTAVLQKRLLRRKKRSRNAKKRKLLTSREKRQLGLMHGPDPPPSYDTFLAVHRMWREYAESLGGAQERLLKAEYTGCHLTVAASRCPSYVGVRGIVLQETKNVFRLLTAEGRVRTVPKAHSQFAFELAGKLHRIYGSHFRVHSFERVKAKFKTKGVVGL
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSSRVLSCDRIEGVASESVNDDIRRGRESGVVEFLLFFFHDRPLVLFRFTIDDRLLLLLLTTLTVVALVFTGVWLNVLVSRVGAAVVVLNEAFQSIDDLYLDEEEIFDGDLLSVVGGSFDTKRCSATVKESHNLGQRLLFQNCVLVRGYEVLCERMRSHDLGQRLFFLRLLLRMRSLLRLWLLM
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MDSATDQTILRHEVAEVAFGFYSDAEIRDLSVKQLTSRLSFDSLNNPVMGGLYDPAMGPVDFNMICPTCHQTQKECPGHLGHIELPVPVYSPVLFGQMFNLLKRKCFTCHKFRVASARSRVVRVKILLLDNGFENEAAQLTELLEQRNGVEDEPPQRTLQRQQAILDEYERLALSKSLSSTNGKTQLLRPLPRLAEVEREKLATEFLKGMKNKCENCGAISPALRQDANAKIFLKGLSARARKVNRSKNLTVTSALDTIRGNVSDGEADPMNGDDSESEMEDDEDKYAMTEDSSSRSKFLPPLEVQSQLQLMWQNEDGLMELLYGDRHIASGRISGRKPDGWRKFFLNVVPVAPSRFRPPVFMGDKQFEHAQNSHLSKIMTLAESIVQGDYYKRQGATTSDEEDAEKEAQVNLSRKLALWTELQNAVNLLVDSSKAKPGTDVAQGIKQVIEKKEGLFRKHMMGKRVNYAARSVISPDPYISTSQIGVPLRFAKTLTYPQPVTPWNVEEMRQLVINGPDVHPGANFVESENGRLIDLSKRSPHQREAISKTLLTRSASAQGTSKNRVKRVWRHLKTGDVVLMNRQPTLHKPSIMAHTTRVLTNPKMQTIRMHYANCNTFNADFDGDEMNMHFPQNELARSEAYNIASNDNQYIVPTDGSPLRGLIQDHVDSGVKLTQRDTFLTKDMYMQLLYNAWASMEDAGVEKAHIETVAPAILKPEPLWTGKQVITSVLKLLTKGLPPLNLDSKAKIKGDLYGSANNEHVVIFRDGELLQGVLDKSQFGASMHGMVHACYEVYGARIAADLLSALGRLFTCYLQFAGHTCAMEDLTLNKAAEKRRRKLVEDSEVMGEEAYAEFAGLTELLEMKRESEKDGKKRRMNEMERTQIRDRMRTLLSGTDAADNAKALDAHMMGCVHGSNSDIIKTCLPSGQSKPFPKNNFSLMVLTGAKGSMVNHSQISCGLGQQALEGRRVPILCSGRSLPSFEPFDPAPRAGGYVTDRFLTGLRPQEYYHHCMAGREGLVDTAVKTSRSGYLQRCLIKHLEDLQVGYDHTVRNSDGNVVQFLYGEDGVDPVQSAMLSGKDAQFDFQAMNHRSISHKHGINAKFFEKTKLDIMKPLKLHEEVREAKDNDFASTSSVLKPGVKAMCRRLKQGETKWKRGTIELGFHAAEIVAVVEENEDGRESKYDIKYLDTGLKAFGVPRTTKFKASKPTNTTRAMSGRVDIIKVSLEDPVMQSLPLNDHVGLISERIQDKLRSYNKRNPSHCLELKKKKKSKKSKKSKHDGDGEIDRDAMQSKHLVTPDAFQLLVWVNYLRSMCSPGECVGILAAQGIGEPSTQMTLNTFHLAGHGAANVTLGIPRLREIIMTASQKMSTPMMTIPLRDDVDSSRAQEVEQRLNQVALSELINSTNGVRVKDEFHSSENGILWVRDYQIRLTFFQLEEIKRVFGLSADQVFNSVGRGFVGKLLTLISREMKKSGVTVSAKAESNNFSAPAASDRKKKGDDDDDDDDEQGTLRFGSRGEVQGYGEMDEEDEKIRKDQMANDDLDNDSDDEASGINDMNSSDDEPAENGKKTFAANGMESLEVPNSVRKNPYFVFCGRNEKKNFVELHLRFPTHSKTLLMVPLVEKIAKQVLVQYCPGISRCYLINQRIGEAQEEKPCVQTEGLNFQEIWGFDDILDVNNLATNDVYKVLQTYGVEAARASISKQIMDVFGVYGISVDPRHLSLLADYMTAQGGYMPLNRMGMNYKGSSLQQITFETSMKFLSQAALGGLVDTLESPSARLVLGQPPRVGTGSFSLLQPIAL
The following text describes a protein:
Function:
Involved in the degradation of the plant hormone indole-3-acetic acid (IAA). Catalyzes the hydrolysis of the cyclic amide bond (lactam) of isatin (1H-indole-2,3-dione) to yield isatinate (2-(2-aminophenyl)-2-oxoacetate).
Sequence:
MSAQSALSGLGAKLLSGEVEVVDCTGVLGPNTPILQLPPDFAKNTPKVEIHKISEYDSDGPFFAWNWMVLGEHSGTHFDAPHHWITGKDYSDGFTDTLDVQRLIAPVNVIDCSKESAADPDFLLTADLIKAWEAEHGEIGAGEWVVMRTDWDKRAGDEAAFLNADETGPHSPGPTPDAIEYLLSKKIVGWGSQCIGTDAGQAGGMEPPFPAHNLLHRDNCFGLASLANLDKLPAKGAILIAAPLKIERGTGSPIRALALVPKA
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MALFLINRYTGEKENKEINRKRNAETVLLELQKKAKIQKVVSEKLTLSDEKKKKKRKKTKDSKDEVAKLSVQTLPFIEKTGVVVEACQDVQKCETVSKPDKKEETNNVISNTISSENPYDPLSQFKEGLKKKELGFQILGEDVESHQTKVTRHLPEWITNRIIINDVKSELISTSDIQPNIDQVLIQNLKDIGITQLFPVQQKVIPYILRDAQRSISHQLFPPRDLCVSAPTGSGKTIAFALPIVQALLQRVVPATRALVVSPTRELSAQIYKVFVSLCRNTQLKCILITAAKGSLLQEQRALLNFGFLTALVRRKPPRMKLKTGLACPADIVVATPGRLADHLSQTSAFSLDKLRFLVIDEADRMMEQIHQRWLTLVEQKVYKDSFKPLPQHLALKRCSYINHICLQCHQESNTGKRNLIQLQKLLFSATLSADPEKLQQLNLFQPRIVFISTYKKKTVLPHNIKQYMIHCTAGEKPLITLNLVLNKTRVLCFAGSIETTRKLSMLIQMYADKEGKKEFICTEFASHLPSSKRGKVLKDFISGKINVLVCSDSMARGLDVPCVEHVILYDVPPLIKTYIHRIGRTARAGATGTAYTLLRKQEIFHFKKMIADAGKCKVKTMKIPKESTQKMVSIYEQVLPMVAEKMKTLKR
The following text describes a protein:
Function:
Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Is also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). By regulating VPS34 kinase activity, VPS15 appears to be essential for the efficient delivery of soluble hydrolases to the yeast vacuole. May function as a G protein beta subunit to propagate the pheromone response at the endosome with GPA1.
Miscellaneous:
MISCELLANEOUS: Present with 279 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Lipid-anchor. Endosome membrane; Lipid-anchor.
Domain:
The WD region forms a seven-bladed propeller resembling that of typical G-beta subunits and is required to bind GPA1 and ATG14; Truncation of 30 residues from the C-terminus results in a temperature-conditional defect in protein sorting.
Sequence:
MGAQLSLVVQASPSIAIFSYIDVLEEVHYVSQLNSSRFLKTCKALDPNGEIVIKVFIKPKDQYSLRPFLQRIRAQSFKLGQLPHVLNYSKLIETNRAGYMIRQHLKNNLYDRLSLRPYLQDIELKFIAFQLLNALKDIHNLNIVHGDIKTENILVTSWNWCILTDFAAFIKPVYLPEDNPGEFLFYFDTSKRRTCYLAPERFNSKLYQDGKSNNGRLTKEMDIFSLGCVIAEIFAEGRPIFNLSQLFKYKSNSYDVNREFLMEEMNSTDLRNLVLDMIQLDPSKRLSCDELLNKYRGIFFPDYFYTFIYDYFRNLVTMTTSTPISDNTCTNSTLEDNVKLLDETTEKIYRDFSQICHCLDFPLIKDGGEIGSDPPILESYKIEIEISRFLNTNLYFPQNYHLVLQQFTKVSEKIKSVKEECALLFISYLSHSIRSIVSTATKLKNLELLAVFAQFVSDENKIDRVVPYFVCCFEDSDQDVQALSLLTLIQVLTSVRKLNQLNENIFVDYLLPRLKRLLISNRQNTNYLRIVFANCLSDLAIIINRFQEFTFAQHCNDNSMDNNTEIMESSTKYSAKLIQSVEDLTVSFLTDNDTYVKMALLQNILPLCKFFGRERTNDIILSHLITYLNDKDPALRVSLIQTISGISILLGTVTLEQYILPLLIQTITDSEELVVISVLQSLKSLFKTGLIRKKYYIDISKTTSPLLLHPNNWIRQFTLMIIIEIINKLSKAEVYCILYPIIRPFFEFDVEFNFKSMISCCKQPVSRSVYNLLCSWSVRASKSLFWKKIITNHVDSFGNNRIEFITKNYSSKNYGFNKRDTKSSSSLKGIKTSSTVYSHDNKEIPLTAEDRNWIDKFHIIGLTEKDIWKIVALRGYVIRTARVMAANPDFPYNNSNYRPLVQNSPPNLNLTNIMPRNIFFDVEFAEESTSEGQDSNLENQQIYKYDESEKDSNKLNINGSKQLSTVMDINGSLIFKNKSIATTTSNLKNVFVQLEPTSYHMHSPNHGLKDNANVKPERKVVVSNSYEGDVESIEKFLSTFKILPPLRDYKEFGPIQEIVRSPNMGNLRGKLIATLMENEPNSITSSAVSPGETPYLITGSDQGVIKIWNLKEIIVGEVYSSSLTYDCSSTVTQITMIPNFDAFAVSSKDGQIIVLKVNHYQQESEVKFLNCECIRKINLKNFGKNEYAVRMRAFVNEEKSLLVALTNLSRVIIFDIRTLERLQIIENSPRHGAVSSICIDEECCVLILGTTRGIIDIWDIRFNVLIRSWSFGDHAPITHVEVCQFYGKNSVIVVGGSSKTFLTIWNFVKGHCQYAFINSDEQPSMEHFLPIEKGLEELNFCGIRSLNALSTISVSNDKILLTDEATSSIVMFSLNELSSSKAVISPSRFSDVFIPTQVTANLTMLLRKMKRTSTHSVDDSLYHHDIINSISTCEVDETPLLVACDNSGLIGIFQ
The following text describes a protein:
Function:
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MANSDSPEQNENHCSAINSSIPLTPGSLPTLTLSGKIRVTVTFFLFLLSTIFNTSFLLKLQNWTQRKEKRKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITKPLAVKSNSKLGQFMIGLAWLLSSIFAGPQLYIFGMIHLADDSGQTEGFSQCVTHCSFPQWWHQAFYNFFTFSCLFIIPLLIMVICNAKIIFTLTRVLHQDPHKLQLNQSKNNIPRARLRTLKMTVAFATSFTVCWTPYYVLGIWYWFDPDMVNRVSDPVNHFFFLFAFLNPCFDPLIYGYFSL
The following text describes a protein:
Function:
Ligand for cxcr3.2. Chemotactic for macrophages.
Subcellular Localization:
Secreted.
Sequence:
MYVFAWVWIQSYYPCFNYFLVLKCQCLRTSKTVQPSLIKKVQEIPPRPYCSKLEIIVTLKNNVKVCLDPTHKFAKAIFFYCFFNKVLNTHNTNTASVQMRNTA
The following text describes a protein:
Function:
Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Glucose is not transported, but can compete for xylose binding sites and can inhibit xylose transport (in vitro).
Miscellaneous:
MISCELLANEOUS: E.coli has two D-xylose transport systems that accumulate sugar against a concentration gradient: the XylE system which utilizes the electrochemical gradient of protons and that is insensitive to cold osmotic shock and the XylF system that uses a high-energy phosphate compound and is sensitive to cold osmotic shock.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNTQYNSSYIFSITLVATLGGLLFGYDTAVISGTVESLNTVFVAPQNLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFFISGVGSAWPELGFTSINPDNTVPVYLAGYVPEFVIYRIIGGIGVGLASMLSPMYIAELAPAHIRGKLVSFNQFAIIFGQLLVYCVNYFIARSGDASWLNTDGWRYMFASECIPALLFLMLLYTVPESPRWLMSRGKQEQAEGILRKIMGNTLATQAVQEIKHSLDHGRKTGGRLLMFGVGVIVIGVMLSIFQQFVGINVVLYYAPEVFKTLGASTDIALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLGTAFYTQAPGIVALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIRGKALAIAVAAQWLANYFVSWTFPMMDKNSWLVAHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEELEALWEPETKKTQQTATL
The following text describes a protein:
Function:
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAHLVWMLGENGEEKSFENPNELLPLSRLEEIGVLYWHLDPKKSESEEELTKIRRERGYSYFDLTEICPDKLENYEEKLKSFYCEHIHADEEIRYCLEGSGYFDVRDKDDKWIRIWIKEGDMIILPAGIYHRFIVDSNNYIKLMRLFIGEPVWTAYNRPQEDHPVRQEYVKNVKGDTGFALAAH
The following text describes a protein:
Function:
G-protein coupled receptor that plays a role in the regulation of circadian rhythms and energy metabolism. Participates in maintaining proper circadian gene expression in the suprachiasmatic nucleus (SCN), the locus of the master circadian clock in the brain. May function as a coordinator of aging-associated metabolic dysfunction, stress response, DNA integrity management, and eventual senescence. Upon binding to adropin, modulates mitochondrial energy metabolism via the p44/42-PDK4 signaling pathway, influencing pyruvate dehydrogenase activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAVSGNVSGNCSRVVSTANCPGTPEITLEVFFLIVIFIGALVGNVLILLVVRRSRRNEWTTNYFVTSLAVSNLTSPFLCVFWVLVWITSGKWLLGNISCKTTFFFHFLNVGVSAGLLACISLDRFYVVVHPLSFKMTKAQTKELIVFVWVFMICATAPSLYFFKTKSISNNNELIYCITDFDTVEWKVFITLLVLIPFGCPLITTLALYCRITQAILFRNRQAMNLTNDFRRQANQVPKSKIKVLRMLVIQWLVFVASWLPLLITMAVQALKLVDFSESLYIATLVISFANSGLNALIYSLFNGDFRRGCKRVFCKPDSSQAYRLTSIPRKNRIAPTLESFSSEHIEGYEMRLPELKPFKHYSLNGTADKQIHQAWVTNCIVARDSV
The following text describes a protein:
Function:
Serine protease. Involved in the production of the competence and sporulation stimulating factor CSF. Is directly involved in the processing of pro-CSF to CSF. Can also cleave pro-PhrA to PhrA, but cannot cleave pro-PhrE. Shows fibrinolytic activity in vitro. Not essential for growth or sporulation.
Subcellular Localization:
Secreted. Secreted, cell wall.
Sequence:
MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEVFGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKVNREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQMDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDPKETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAGVERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSPGTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEAKDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPTIKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAPGVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNTAVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFTIENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEGTVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFLVYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVLTEEPFTVE
The following text describes a protein:
Function:
Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKPKKANVATIKNVNLEKQITEGRVAKNKNKDKVKLRAEESANIDARSSQKILAAAKLQQLELDEENFPSLVTVKKVNFSLNDGHVKEDEEVNETDLMADLDMDEDDVAAFERFQQPAQEGKRTLHLSKMIMQKIQEKEADIHTKISDEGSLKIEEIDPKVKEMYEGVRDVLKRYRSGKIPKAFKIIPKLRNWEQILFITEPHNWSAAAMFQGTRIFCSVLSQAMAQRFYNLVLLPRVRDDLCEYKKLNMHLYNALKRALFKPAAFMKGIILPLLEGGDCTLREAIIFGSVVARSSIPVLHSSACLLKICEMAYSGANSIFIRYFLDKRYALPYRVVDAAVFHFLRFENDKRELPVLWHQSLLTFAQRYKNDISSEQRDALLQLLKKKSHFKITPDVRRELQAASCRDVEMMETDNGLAGQPAKMYTDADVEYEG