lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.
Subcellular Localization:
Early endosome.
Sequence:
MDTDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRSAASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVEFVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKNKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLEPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKSPDALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT
The following text describes a protein:
Function:
Essential for recycling GMP and indirectly, cGMP.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVKVISPFSQDGVQCFPKLFIISAPAGAGKTTLTHMLQREFPDAFEKTVSSTTRSARPGEVHGVDYLFVSEDDFKQSLDREDFLEWVFLFGTYYGTSKAEISRVLQKGKHCIAVIDVQGALALKKQMPAVTIFIQAPSQEELERRLNARDSEKDFQKKERLEHSAVEIAAASEFDYVVVNDDLITAYQVLRSIFIAEEHRMSHG
The following text describes a protein:
Function:
Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum. Golgi apparatus. Mitochondrion.
Sequence:
MADRAAETGAAVPPRDCASSESPAEAVGTERRGTEREEDGEEEKSGAGGPDGSEPKRRESGARAESAEKGHESGDGACGSTAEKRGEPRDGAPVGGGSQLRILLVGKTGSGKSATGNTILGMEVFESKLSDSSVTSDYSKAEGSFYGRTIEVVDTPGLFDTREGNLKTAEKIKNGLRYLSTGVHAIVFVMQLGRITKEEQEVVEWVTKIFHVEAQRYTILLFTRAEELEDAEGLKCFVEESSYLKALAAKCGNRYIAFSNRATREARDGQAAELIHMIDAMVEQNGDAPRYTREMLEKDRRNFLEKAPHVSAMPVSGHHSTGSQLSIILVGKTGSGKSAAGNTILGREEFKSKLSDSSVTCDYNSAKSIFCGRTIEVVDTPGLFDTREGNLKTAEKIKNGLRYLSTGVHAIVFVMQLGRITKEEQEVVEWVTKIFHIEAQRYTVLLFTRAEELEDAGGLKGFVEESSYLKALAAKCGNRYIAFSNRATREARDGQAAELIHMIDAMVEQNGDAPRYTREMLEKDRRNFLEKAPYASALPMAGHHSTGSQLSIILVGKTGSGKSAAGNTILGREEFKSKLSDSSVTCDYNSAKSIFCGRTIEVVDTPGLFDTREGNLKTAEKIKNGLRYLSTGVHAIVFVMQLGRITKEEQEVVEWVTKIFHIEAQRYTVLLFTRAEELEDAGGLKGFVEESSYLKALAAKCGNRYIAFSNRATREARDGQAAELIHMIDAMVEQNGDAPRYTREMLEKDRRNFLEKAPHVSAVPVSGHHSTGSQLSIILVGKTGSGKSATGNTILGKEAFCSTLSAHSVTHNCEKAKGHFCGRPIIVVDTPGLFDTGEVIRTSIEKIKNAFQNLCAGVHAIILVMQLGLFTREEQEVAEWLTKIFHTEGRNYTILLFTRAEELEHPEALKAFIEGSSYLKGLAAKCGNRYIGFSNKATREVKDGQVEELIHMIDAMVEENGDAPCYTREMLEEDTQELSRLCTIL
The following text describes a protein:
Function:
Probable inactive ADP-ribosyltransferase that may be involved in stress and developmental responses.
Subcellular Localization:
Nucleus.
Sequence:
MDYSKTEETPINEEQGSTNSSESRSNEELFSDCDQQHSSIANEFGLTELPKDDKVYELIYRHCQSKLTSHLSNQFEIVSILKNGFQTPLGQAKLKAFQIYAESVAKKSGSCCGNKAAVAEAARVKYGCCGVEKEELKAILMYGFSNNALCLSPDNAPLQCMIDPSSSCNEDGISFLLFSRIIMGKSEVVCSTSQSYPSSMEFDSGVDSLTSPNKYIIWSTHMNTHVLPEFVVCIKTPSILKRKNPKSPWISFPVLINSISKFLNQSQIRLIHKHYKEHQDRRISRCELIQRLRSITGDSLLVQIIKSVGQKVHKDT
The following text describes a protein:
Function:
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
Subcellular Localization:
Cytoplasm.
Domain:
Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
Sequence:
MAFLNHIYGKLLKIHGDSLIIDTGNFGFKIYVSKNLTSKLSEELNNKILLYIAEVIEKDGIKFFGFLSEEERDLFERLKNITGVGIKIALRIVSAMSPKEFYEVIEKEDLNALLMVPGVGKKITQKIFLEIKGVIPKREHKEEDIIKDTLLNLGYKKEEIEVVMKEIRKEFKDLDNLEEIIRFALRKLSQEI
The following text describes a protein:
Function:
Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MAPKVAIIGAGASGLCSIKEALDAGLEPTAYEKASWLGGIWNFSEDPEQSCAALCTITNTSKHVMCFSDFPMSKTCPNYLPMKTYQAYLESYAKEFNLVKNIRFNVSVIEVKKCADFEETGKWEVHSIAGNSQTIKMEVYDFVMVASGKLSEPFIPEIPGMESFPGKLIHSKEYKTFRGFENRRILVVGLGNSAGDIACELSRHASQVYISTRRGTWVLPRLGPGGAPIDLSISRLVYHLPRSFLSWLVAQRVKGSYNLANFGLETEEEPMKALIINDELPHRIVTGSVIVKSDIKSIKGSSILFSDDTTLDDIDIVIFATGFNVRYPFLSNSWLQPKEDYIPLYKFVFPFEPSKPTIAIIGAFTNEGPIPPCCEMQARWVVQVFKGNARLPDKQKMIKEILDAQEEIKKRVTYTGNRYFHKLKGMVPYLDEIGSLIGARPSMLKLALKSPALALKCYFGTCIPAQYRLVGPGAWGGAEKVIWEVEESFLTPMKTRAVSLADDKGKSKIYLFMFGVIIVLVACWLACCSA
The following text describes a protein:
Function:
Binds sialylated glycoproteins.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MEKSIWLLACLAWVLPTGSFVRTKIDTTENLLNTEVHSSPAQRWSMQVPPEVSAEAGDAAVLPCTFTHPHRHYDGPLTAIWRAGEPYAGPQVFRCAAARGSELCQTALSLHGRFRLLGNPRRNDLSLRVERLALADDRRYFCRVEFAGDVHDRYESRHGVRLHVTAAPRIVNISVLPSPAHAFRALCTAEGEPPPALAWSGPALGNSLAAVRSPREGHGHLVTAELPALTHDGRYTCTAANSLGRSEASVYLFRFHGASGASTVALLLGALGFKALLLLGVLAARAARRRPEHLDTPDTPPRSQAQESNYENLSQMNPRSPPATMCSP
The following text describes a protein:
Function:
Catalyzes heptose transfer to the lipopolysaccharide core. It transfers the first L-glycero-D-manno-heptose to the phosphorylated 3-deoxy-alpha-D-manno-octulosonic acid (Kdo-P) of the inner core.
Sequence:
MPLFTEAPKSLCILRLSAVGDVCHALAVVQHIQEYYPQTEMTWIVGKTEMGLLSSIPNITLIPYDKKTGWKGVLSLWKQLKNKQFDALLNMQTAFRASILSLGIKAKFKIGFGEKRSREGQWLFVNRRIRDPFSPHVLDGFMAFAEYIGVPKAEPKWELAISQDDYKFADQFIDFSRKNLLISPCSSKAEKDWLIEGYAEVANIAHQHNINVIFCSSPAKRELEIVEKITALCHFTPTNIAGKTNLKQLTALISKVDLVLSPDSGPAHIATTQGTPVIGLYAYHNPLRTAPYNNLDNVVSVYEENAQKEFGKPSSELPWATKLKGKNLMTEIQVEPVIGQMKKLGLF
The following text describes a protein:
Function:
Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates.
Sequence:
MKMLFRVSWPFQRMAPAPSCCRRSSPALRRVYRVGRLLHTAGTIRSDRAAPVFTRALAFGDKIAIADQRGQYSYKDLYFKSLRLSQHICRLRDCPDGDVKEERISFICSNDVSYVVAQWASWMSGGIAVPLYRKHPASELEYFIQDSQSSLVIAGEEYVDLLTPVVKKIGVQLLPLTPAVFDSGRGEQAAELCPEREWKDRGAMIIYTSGTTGRPKGVLSTHRNIRAVVTGLVDKWAWTKEDVILHVLPLHHVHGIVNKLLCPLWVGATCVMLPEFNAHEIWEKFLSSKAPRINVFMAVPTVYSKLMDYYDRHFTQPHVQDFVHAVCKDKIRLMVSGSAALPVPVLERWKTITGHTLLERYGMTEIGMALSNPLNGTRVPGSVGTPLPGVEVRIASENVKEDRPLIIYAQGNEKETKVTPGSEGKEGELLVKGPSVFREYWNKPAETRNAFTPDGWFKTGDTVVFRDGRYWVLGRTSVDIIKSGGYKISALEIERHLLAHPSIMDVAVLGVPDITWGQRISAVVKLQEGDSLSYKELKEWARDRMAPYTIPSELLLVEEIPRNQMGKINKKDLLKQFYPA
The following text describes a protein:
Function:
Histone methyltransferase. Methylates 'Lys-79' of histone H3. Required for Polycomb Group (PcG) and trithorax Group (trxG) maintenance of expression. Also involved in telomeric silencing but do not in centric heterochromatin. Probably participates in pairing sensitivity.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones; MISCELLANEOUS: Was named 'grappa' because the eyes of mutant flies are of a color similar to that of the Italian spirit.
Subcellular Localization:
Nucleus.
Sequence:
MATPQVKDLVLRSPAGSSDVISFAWPLQIGHGQDKHDNGIDIIDTIKFVCDELPSMSSAFEETNLHQIDTACYKTMTGLVDRFNKAVDSIVALEKGTSLPAERLNKFAHPSLLRHILQLVYNAAVLDPDKLNQYEPFSPEVYGETSYELVQQMLKHVTVSKEDTFIDLGSGVGQVVLQMAGSFPLKTCIGIEKADTPARYAERMDVIFRQYMGWFGKRFCEYKLIKGDFLVDEHRENITSSTLVFVNNFAFGPTVDHQLKERFADLRDGARVVSSKSFCPLNFRITDRNLSDIGTIMHVSEIPPLKGSVSWTCKPVSYYLHVIDRTILERYFQRLKTKGGNDHESVGTVRTTRDRAKREANVGQHHHNNHHSNNHANSNNHQRDREQSNGATATAAHQQRHQSQSPANVSGAGIVLAASGQQAASKTRQQLQHQHNQQQRSLDMESSTESDGDATNGNGGNTTTATNTTSASNGPMTRKVWSDWCSSKGKSSQSDDEENNNSNSNGGSNGGSIGGGSVGRQARATTQKKRKKLTRKAAIASKSAAAAQREAEAAAAAAVSVPSKESSSKEDPPRAASAGPGRKGRMKKGARGRKSLKIVGLEALHKQTVLSTSLDTMTKKLPAAPGTVDQQLTALLTENMSHAELDIPTAPQDTPYALQILLDVFRSQYTSMIEHMKSSAYVPQVQKQIAQEQERMARLKNRASQLDKQIKVLIDDSVALLKVRMNELGIHVNSPNDLIAQAKEIVGRHKDLQHTASRMRNEVTFYEGEQKLLLNKQLKNLPEYQKLCGTVNGKVKLEVPPELSETTAQELVLKEIANTLSQRKKLYAQVSTIEQETSVLQKTAEERSTAATLLAQGTNMIVSTGSSSSSSTTVCASAVTAQSNKLNSVKNSRRNREHRARSQEWPEVPEVGKIQESNPEVLAQKIVETCRQIEAGKFQGAGAPSSQVNGKNKAIIEVPPPPATAPVSIKSSPGHHYKDTTLMPAPKQQQQQQMTLSQLPKCELPGLSTSRKQESPKVANFEDRLKSIITTALNEDQEQRSKAVESSPSPSPLHSPAPKRSKQHPAGAINPAQSLPNNLHNIITVSTQGLMHLNANTTISPITPPLPGPGAGATASTAPPPPANLPYGAYGGAVAKTTISGKYQAAKEPKYSPVRQAPLPPPPSHMASLYPAGQQTTPADLGYQRRRSSVSATSYEHYMVQQQQQLQQQQLMLAAAAHAAQRQQMRVEEQQQQQQHQHHHHHHHHHPQHRLPQHVQHQHPHQHHPNEFKAPPADSHLQRSSSREQLIVEPPQTQPLELLPRASSANSDYSGYRIRPPSRPSSNSSQPDYTQVSPAKMALRRHLSQEKLSQHVTPQATPPLPGHGGAPTSGKTIGDLVNGEIERTLEISHQSIINAAVNMSTSGASFMERAFLNERSNDRLLINLNAQRPERVHVRPLSEESQDPQPTSYAQERGPGLGAGGAAAGGNSNLATLAHVAYAQKAQGGARANAGTAPPATHSSSARSGRDYQPVALPRAELKGSIEAYFHEEQQQKQSKGAGSAGSSSLRGPRLNGANPPLEGLAASLQDHVRARKYKEETEERQRRAAAAASSSAGPPAGMELPTHYAHQAPPAHSYHHHGASINGTPHKVELGIKRSSPLAPHQQPPRPSKLAHYEPPTTQQQHAHAHLYANGQVLPPPPAHDATTPSPTPSSSSSSCGRRSNSNNGKLLVDPPLLMSPEINSLLGDERPLQLSHHQQQQQQMLHHHQSQQQQHLQLTQQQLRVAHLGHGLSHGHSTMPTLGGQRNGNGNAADDVNDLATQRTITNYDPRRRLRTTLSGPTKLSAAHSNQNLNGYVMADSSSSCPTIPQ
The following text describes a protein:
Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDSEPSSGTSVSTTASSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSILSASPAPAQLMNRSQTSSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSPSPSCQSAAAQVQNLTLRSQKLGVLSSSQNGSPKSAGQTQSLTICHNKTTVTSSKISQRDPSPESKKGGSPGLESRSTAVTRTSSIHQLIAPASYSPIQPHSLIKHQQIPLHSPPPKVSHHQLLLQQQQQQIQPITLQSPSQDPPPSQHCIPLPNHGLSPAPSNAQPQHCSPVQSHPPPLTVSPNQAQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQTGPNLQQAAADQVQSTAQLNLPSHLPLPASPVVHIGPVQQSALVSPGQQMVSPTSHQQYSALQSSPIPIATPPQMSASPPAQLPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVVYQVEDVCEEEMPEESDECARMDRTPPPPTLSPAAVTVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPTHASAPAPPLLIPAASTRSSSTSLASSTPSLENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSLLIEQPVKKRPLLDNQVVNSVCVQPELQNNTKHADNSSDTEIEDMMAEETLEEMDSELLKCEFCGKMGYPNEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSGPEGAAREHILRQLPITYPSAEEDVASHEDPVPSAMTTRLRRQSERERERELRDVRIRKMPENSDLLPVAQTEPSIWTVDDVWAFIHSLPGCQDVADEFRAQEIDGQALLLLKEDHLMSAMNMKLGPALKICARINSLKDS
The following text describes a protein:
Function:
Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction.
Subcellular Localization:
Early endosome.
Sequence:
MKGLYFQQSSTNEEVTFVFQEKENVPVTEDNFVRVQVKACALSHINTKLLAEMKMEKDFFPVGREVSGIVLEVGRKVTFFQPDDEVVGILPLDSEDPGLCEVIRVHEHYLVHKPEKVSWTEAAGVIRDGVRACTALYYLSQLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTAHSLEDKQHLERLRPSIARVIDVSNGKVHVAESCLEETGGLGVDIVIDAGVRLYSKDDEPAVKLHLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGATVAFLNDEVWNLSNAQQGKYLCILKDVMEKLSAGVFRPLLDEPIPLYEAKVSMEVVQKNQERKKQVVQF
The following text describes a protein:
Function:
Involved in regulation of neurogenesis. May encode a lateral inhibitor of R8 differentiation. In conjunction with Gp150, promotes Notch activation in response to Delta by regulating acquisition of insensitivity to Delta in a subset of cells.
Subcellular Localization:
Late endosome. Note=Colocalizes in late endosomes with Gp150.
Sequence:
MRDWQTFPDLQKKKVSRDHLNCPATMAGSNVLWPILLAVVLLQISVAFVSGAASGGVVLSDVNNMLRDAKVVTSEKPVVHSKQETEAPESSVELLRFVDDDEDSEDISSIERQDGRTMESKKMADQVRLLTKQLNALMLRRREDYEMLEHNLRKSLRLTTNANSVDADMRSELNQLREELAALRSSQSGNKERLTVEWLQQTISEIRKQLVDLQRTASNVAQDVQQRSSTFEDLATIRSDYQQLKLDLAAQRERQQQTEVYVQELREEMLQQEQDFQHALVKLQQRTRKDGSSASVEEESGSQEANQEQTGLETTADHKRRHCRFQSEQIHQLQLAQRNLRRQVNGLRFHHIDERVRSIEVEQHRIANANFNLSSQIASLDKLHTSMLELLEDVEGLQTKMDKSIPELRHEISKLEFANAQITSEQSLIREEGTNAARSLQAMAVSVSVLQEEREGMRKLSANVDQLRTNVDRLQSLVNDEMKNKLTHLNKPHKRPHHQNVQAQMPQDDSPIDSVLAETLVSELENVETQYEAIINKLPHDCSEVHTQTDGLHLIAPAGQRHPLMTHCTADGWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQDIYDNVWVAEYKRFYISSRADGYRLHIAEYSGNASDALNYQQGMQFSAIDDDRDISQTHCAANYEGGWWFSHCQHANLNGRYNLGLTWFDAARNEWIAVKSSRMLVKRLPAVECQANASASGAFVSVSGSAADAAPSSGATTTTTTATAAPATVTTPKTNNSVVQFVAAGQA
The following text describes a protein:
Function:
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (By similarity). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution (By similarity). Cleaves caspase-3 and -9 (CASP3 and CASP9, respectively) to give rise to active enzymes mediating apoptosis. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair.
Subcellular Localization:
Secreted. Cytolytic granule. Note=Delivered into the target cell by perforin.
Sequence:
MKILLLLLTLSLASRTKAGEIIGGHEVKPHSRPYMALLSIKDQQPEAICGGFLIREDFVLTAAHCEGSIINVTLGAHNIKEQEKTQQVIPMVKCIPHPDYNPKTFSNDIMLLKLKSKAKRTRAVRPLNLPRRNVNVKPGDVCYVAGWGRMAPMGKYSNTLQEVELTVQKDRECESYFKNRYNKTNQICAGDPKTKRASFRGDSGGPLVCKKVAAGIVSYGYKDGSPPRAFTKVSSFLSWIKKTMKSS
The following text describes a protein:
Function:
Involved in chemotaxis. Required for an optimal chemotactic response.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MRESLGVSLPSRPLLLKLGLLSLPWALCAGLHAVGLGVWLVLALGWFASLAMLVLLLRAPRQAVANANPQADAASPAWSAAQRALADETAQLDGHARQIDELLHSAIRQLSDSFHGLAERIDTQRGLSHSLIERYDGRGQVDEGINFQDFVRTTQQTLSLFVEATLETSRTSQQLVERMDQVRLKITEILQSTQDMDAIAKQTNLLALNAAIEAARAGESGRGFAVVADEVRALSTRSTEFSAAIRKHVDVVHHEIQDAESAISQLADKDMSFALDSKHKIQGMLDDLEAMNRHTLKVIHELDRLSLEVGQGVDAAVTALQFQDMGSQLLGQMRKHHARLGAFALGLGALEARPRQEWPERVAREVEELRRPLPSPVSQNSVNVGEVELF
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Dispensable for SPC enzymatic activity (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDGMIAMLPAPLQQLSSHIDFQGQKVAERTYQVILTLAGIIGFFVGYSTQQLSYAMYTVMGAAVFTALIILPPWPFLFRKNPIVWQTPIEEQEASSSSDNEKKDKKKETKKTK
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MHKILLRNSVGTCLYLTDLTPSTKCCWSHKIPTVFTSTLVCSILAKTIAFKSLVAVWFMPLNILLTFIIGTTLGWLFMKITKAPPDMQGLVLGCCAAVGRVSEKETDLENHSTGPVIIAEDLSQTNDHVSQFGSECTLPGGRDMMIPKQKKIMKPMKTLVQKLNLKILGLIICVVRPFQKMFVGDDVPLGVIEDSSSLLG
The following text describes a protein:
Function:
Initiates the restart of stalled replication forks, which reloads the replicative helicase on sites other than the origin of replication. Recognizes and binds to abandoned replication forks and remodels them to uncover a helicase loading site. Promotes assembly of the primosome at these replication forks. Serves as the initiating protein for assembly of the replication restart primosome; binding of PriA to an arrested DNA replication fork with unreplicated lagging strand triggers assembly. Sequentially DnaD (possibly as a dimer) and DnaB homotetramers bind. Assembly probably continues by loading of the DnaC replicative helicase aided by helicase loader DnaI (Probable). A single-strand (ss)DNA-dependent ATPase with helicase activity. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. Binds forked DNA substrates and makes a larger complex with RarA; RarA has no effect on the helicase function. Binds ssDNA, D-loops and replication fork-like substrates but not double-stranded (ds)DNA; the preferred DNA substrate mimics an arrested DNA replication fork with an unreplicated lagging strand. Recognizes nicked dsDNA. A supershift on ssDNA occurs in the presence of single-stranded binding protein (SSB). Cannot substitute for E.coli PriA; Required for replication of plasmids that have a rolling circle mechanism, which produces circular single-stranded (ss)DNA intermediates corresponding to the lagging strand template, which are then converted into double-stranded (ds)DNA; priA is required to activate the conversion of ssDNA into dsDNA.
Miscellaneous:
MISCELLANEOUS: Between 50 and 100 molecules are found per cell.
Subcellular Localization:
Cytoplasm, nucleoid. Note=Localizes in tight foci to the chromosome replication center at mid-cell during most to all of the cell cycle.
Domain:
Contains an N-terminal DNA-binding domain and a C-terminal helicase domain with a number of subdomains, all of which contact ss- or dsDNA. Deletions of the 3'BD or permuted winged helix domain (WH) domains are hypersensitive to methyl methanesulfonate (MMS) and ciprofloxacin (CIP). The WH domain plus its N-terminal linker stably bind single-stranded (ss)DNA; the WH domain alone does not. Deletion of most of the linker (residues 125-166) leads to hypersensitivity to MMS, CIP or mitomycin C.
Sequence:
MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPRKIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQAMLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGDIDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKIPAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAFEPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVNRFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDEEHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKHRVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFVMCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQRVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPNVTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQLTKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGADTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISIDMNPYMMM
The following text describes a protein:
Function:
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.
Sequence:
MAGEFRWQAGRPATAQVGGWVLAHCQQRFLQDDNGLLFPREWLKRQELPLLAEHGVGHWQGEPVYVLELDEPIELPGMAWAPLRQFMLHGDFDQFCMLGYASQIGIWARHNRFCGNCGTRMQAQDHERVMQCPQCGLHQYPRLSPSMIVLVTRGDEVLLARSPRFVPGVYSTLAGFVEAGESVEQCVVREVREEVGVEVANLEYIGSQNWPFPHSLMLGFHAEYVSGEIVPQEDEIEDAQWFSLDALPPLPAQRSIARHLIDLYLARRSGAAEPVLPG
The following text describes a protein:
Function:
Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity).
Subcellular Localization:
Mitochondrion matrix. Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes on the matrix side on the mitochondrial inner membrane.
Sequence:
MAAPWLQRWRGAYAGPSGPLRLVRLHGVQRSSWRAAHAAAGAFGAGPHPGPPQRAANPGPGPHPPPVATSREKHARIVQGRPDQPAEPKVLRISIIGAPNSGKSTLSNQLLGRKVFPVSKKVHTTRCKARGVITHEDTQLIILDTPGLTSPMKAKRHKLEAAMLTDPWDSMKHADLVLVLVDVSDHWTRNSLSLEVLKCLSQFPHIPSVLVLNKVDLLKKKIILLGLINELTEGIVNGKKLKVRSEFEYNSSSPAKTVLKVTQTPPPENRARESPCQLETDKAQEGSSLDNSSDVKASESSLDTEAREQKPYKYGDQKNRKGWPHFQDIFMLAALNGEEVDTLKQYLLMQAKPGPWEFHSRVLTSQSPHEICDNIIREKILEYLPLEVPYGVTQVTELWEEGPSGELIIVQNLVVPRKSHKLMLIGRRGALISRIAQEAGQDLMNIFLCDIRLKLKVEVKS
The following text describes a protein:
Function:
Cognate cyclin for CDKG1. Required for synapsis and male meiosis, and for the proper splicing of specific resistance (R) genes. Involved in regulation of DNA methylation and transcriptional silencing.
Subcellular Localization:
Nucleus.
Sequence:
MIYTAIDNFYLSDEQLKASPSRKDGIDETTEISLRIYGCDLIQEGGILLKLPQAVMATGQVLFQRFYCKKSLAKFDVKIVAASCVWLASKLEENPKKARQVIIVFHRMECRRENLPLEHLDMYAKKFSELKVELSRTERHILKEMGFVCHVEHPHKFISNYLATLETPPELRQEAWNLANDSLRTTLCVRFRSEVVACGVVYAAARRFQVPLPENPPWWKAFDADKSSIDEVCRVLAHLYSLPKAQYISVCKDGKPFTFSSRSGNSQGQSATKDLLPGAGEAVDTKCTAGSANNDLKDGMVTTPHEKATDSKKSGTESNSQPIVGDSSYERSKVGDRERESDREKERGRERDRGRSHRGRDSDRDSDRERDKLKDRSHHRSRDRLKDSGGHSDKSRHHSSRDRDYRDSSKDRRRHH
The following text describes a protein:
Function:
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs (By similarity).
Sequence:
MKLGSTEEKSGGGCSLPTEVSPPALQQAFSKILHGLSRQESSGQGNAGNAALRDLGALIEATECDKLFEGTGGGGSPREMPEILGQVAKALEKFAAPKEKADGSEEHPEVPEKATEVGLLFLKLLGKVETAKSSPVCPAWKTGLRHLSGPTYIFAITHRLKQPWTSPKSQHVAGEVLSLLFRVTECSSVAEFLCGENKDDRGRFAVVLGLLKPHLNKETWKKNPAVKHVFSWTLQQVTQPWLSQHLEKILPPSLLISDDYQTDNKVLGVQCLHHIVINVPAADLLQYNRAQVLYHALFNHLYMPEHRLIQAVLLCLLDLFPVLEKALHWQGEAARASTHCHEVLQLVLTHMESEHRLLLRRTYARNLPAFVKKLGILTARHLKRLEQVILGYLEVYDEPEDESRLKILETLKLVMQYTWPRIPCRVVVLLKALLKLICDIARDTIPTTEAAKSAVLQEATDCLILLDHCSQGQVKGLLANIALSCDDSTVVSCIRKVQGSAEAPGEDPGDD
The following text describes a protein:
Function:
Histone chaperone-dependent acetylase that modifies 'Lys-56' of histone H3 (H3K56ac). Histone H3 'Lys-56' acetylation may be required for S-phase-linked DNA damage tolerance (By similarity). Also acetylates 'Lys-9' of histone H3 (H3K9ac) (By similarity). Autoacetylates.
Subcellular Localization:
Nucleus.
Sequence:
MDNLYTGISKSIESLPPEITFSYGYIFTNFKKLKWPWLNKRKIDNVYLSNHFFFILQEDAMAYAIEVLIFFSSELSVFYISKADSTGFFNRHGSPSPLKAVISTFLSYLIRRFSRKNIPSRISLFSRSQPQYLFPSSSLNPSKHILDDRELVRWWLKVLDSVNGSQCPKKYVLIPGMDPRETLKYTPQHVDTDLNWICGHPYESMGQSAGEIIPRFPDDPKTRFLDQLDRDGEVVSIDKFWELMAFRQECIHGRIVGFFSLEFPGNDQDGTNNTITEDLDLQNGIQINEKIYRMVYEKLLRSDFETLEKSKGATLDLINDINNSKDIKDSVDWIKKVSGKKTSEDKKRKAIDISEQLKPVNILNESLIRKKSKKK