lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MATGNRNPENFTSLSPIVKAPITDTLSVPLSQQGRICGFFESQFYRCMEAYGAKMGRKYCDLEHRDFQECVTGDKQKKRADAIREQRCKLFLDGKIAKPYVDNHPEPGQFKTDHFQWNRIN
The following text describes a protein:
Function:
Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
Sequence:
MTDKFNLAEKNEAWQKILIAFNSKNKRPRNVEQIKNKYDNMKSKARKIAASNKNYLRGIEGGPSQTLDLDPVIEAVLRIINSATVVGLEDPFDCVLDNDQIKVEENSSSADDIKELVYEENSSTYSLENINKHFNYNEQISSANEEQSLEVVDNGVQIQESREEAHKKRTGDWSTYAPKKLRTLMSQNPSEISENPTEEFYRKKMELIEEEIKKSKLEQSVITEKNLRDIEEHQKRMKLLDLEIKIKEQMLNNN
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MYRARAARAGPEPGSPGRFGILSTGQLRDLLQDEPKLDRIVRLSRKVQMEQLLLGEQSLEAFLPAFQRGRALAHLRRTQAEKLQEVLRRRERSAQPAPTTAAAAAAAATAMDPPKPFPAAAVLPTGAARGPPPAVPRSLPPLDSRPVPPVKGSPGCPFGPAPLLSPRPSQPEPPHR
The following text describes a protein:
Function:
Transcriptional activator. In tracheal terminal cells, regulates the transcription of factors involved in the formation of a mature apical extracellular matrix (aECM) which is essential for the integrity and shape of seamless tubes.
Subcellular Localization:
Nucleus.
Sequence:
MKFCSMNGPSESEVESLLMSPCWGPPQTSAQDQYLLDGHKLLLEHDLDSLPSDADQKNSLDVLDNLLLNGSSLNALSDLKPLPPFTGYTGHLSINGISGHHYHAIAQRLPDESNNNYMQSAYHPQNQSNPTSTTQSNGGSNSNSNNSNEHNIVSSSTCLPESVLSGSGGGGGGNDACLADVKLFADSQLDSKLYSVADSCVMNGSGSGSAANGNGSGPSIATLTPIDQVADSLHNSGVRIYKDLTEYVDMNSIDDIAAIIGSAIADTTVPNQLDKDDNNDTRDSWMDLDAWIDGNCIQQESAKVLVSQQDSLGDFILPHSPLPMHASSSTLQSLLSHGYMPLLQNRLQNGPPNGNSSGGGGGANQGAGIKGDPQAPTSTSYCNELAAATSSSCSPPGSVVSTTDNPNGLMINPRYLSNPTNNQATGNLHQQGGYSMQASGLSLKDNGLCSPDLLGNYPHTTTASTTGSEMRTGAPKAKRSRSQKKSNQQQQQQQQQQQQQGDGGGQPTTPQMSAISPSGFSASDLSGLLGKEKPVHRCSICNRGFLNKSNIKVHLRTHTGEKPFRCDVCAKAFRQKAHLLKHQQIHKRIGRD
The following text describes a protein:
Function:
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD-1) complex.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDDRKLAFFTAIEDQGGVIVKGRTRFERLFHIGRSSVPLCVDALKAAVQEAKAGSDILRYQMAVNSLFQAAPNEPEALLDKAWMESKEKENRDTTAHLQAELQGYKNNLIKESIRMGNEDLGKHFEAIGDVEAAMDSFWKMRTEVSSTEQLVDLGKLLVRVAIERRDWKSIGNHLKPLNSVNDSDPKAKALKTYSKIANGIAALGQERYKEAAFCFVEASSGVPPEIYNQIASPNDVAIYGGLLALATMDRHELQANLLDNDSFREFLQREPHIRRAITQFVNGRYAACIEILESYRPDYLLDIYLQKHVPKLYADIRTKSIVQYLKPFSCVRLDTMQKAFNGPGPSIEDELFTMIKDGKLNARIDAINKSKALQTLENYEKQALDRIRRMNIMAADLEVKGSRKPGGMNDIPFSMTTDDTVSLA
The following text describes a protein:
Function:
Removes the phosphate from trehalose 6-phosphate to produce free trehalose.
Sequence:
ELNDTVVEAQLRIKQVPPSLREADSIERYLRSNNRLLILGFNATLTEPVDTPGRRGDQIREMELKLHPDLKQPLNALCHDPKTTIVVLSGSDRNVLDKNFQEYNLWLAAENGMFLRCTTGKWMTTMPEHLNMEWVDSLKHVFEYFTERTPRSHFEQRETSLVWNYKYADVEFGRIQARDMLQHLWTGPISNASVEVVQGSKSVEVRAVGVTKGAAIDRILAEIVHSKKMKTAIDYVLCIGHFLGKDEDVYAFFEPELPDDGPGIPRTRPTDAIKVPGERRQALKVASRGSSKISQGKTQRPAQAPEKKTPNHNCTNVRQPSSDKTSYNVLDLNKENYFSCAVGRPRTNARFLLQSSDEVVSFLKKLADASSSHEAHNGPT
The following text describes a protein:
Function:
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.
Sequence:
MANRNDDWVPIGDSKLKLERIYDDVNLNMKEVIHFSACPYSGPIAVCTSNGDSSFKITIHNSAGKQYSQVQVGDVIVMEWSRGHRLVVVSSRGSITLYTPLGEIVNQYALVRDVHVLSSLLFGASRHSGLAILDDSNRITVVNNVTDPVVWTIHPKDRPTTWTLMQAHSEVTNVVAVVKTTFYRSSQGESLEITDTPWAATEGEYIECSSDWANERIALLHSTHSTRSIHVTLPDLSSLLSTISIAPTLPIHSIGFISDSILFVHRKPSSVQFVSTMDASVYDHSTSFVHLGIECDGVRMYTGDSLIFVSHITQAEDSVVGVAPSAEGSLLVDAQRIMEEGSSTRTPYECIMTIKNMTKAIEECTNAAEKTRSPIQQKSIMKGARMGMAFNSSFDSFPFISLLRLMRIVNECALRRTAIPITLAQLCELSFSSLLSRLVDIDQFGLAIKLSQWMSKDGMETDRVVLAWLKKLIVKSRRKNESAETIDEMIASKLKEFPHVAFADAAEKAMEVGATDLAKKLIGREKNDERQVECLLKLGQVGEALARANTVQQPKLIHMVLRHLSRTLTKSQLELEIRKIPHVLCVYQEYVKQQSSGKQTLSLLTQSGDYERILISHMENAVATGDGPFASEEREQSLMDGKEAASLIRDSSLADLLQEAANRNTTTRMAVMDAVADPEAVARIAKQCKLNERQIHEWTVEGLARAHRWSHLMEFAKKKSPIGYAPFVRSCIRYGRKDEADKYLLKATLYEDQIEANLLLGKFVNAGKMAFDRRDEEMLRRIQGRALIENGEMSRKVGKMIESL
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MDGQNDGMFIDRAEDARKQEITEQYLNFLDNQSDTHHYRQKIVKMMNDGESRLVMNLDEIREVMPERAEGLLTQSVLEMNCLQSALEMAINRSDVQAIVKTGFHVGFEGTFGERHVNPRTLKSSYLGNLVCCEGIVTKCSTVRQKLLTSVHYCPATNKVLEKKFADFTMLDTVVTNNAYPTEDENKNPLETEFGHSVYKDHQTFTIQELPESAPAGQLPRAVDCVADLDLADRVKPGDRVRIIGIFRVLPNKQNGVSSGSFRSIIILNHIQMLSKEVIPNFEPQDVRDVRKISKSRDPFDLLASSLAPSICGHEETKKALLCLLLGGMEKILNNGSRLRGDINVLLIGDPSVAKSQLLRYVLRMAPRAITTTGRGSSGVGLTAAVTTDPDSGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHAKLNARCSVLAAANPVYGRYNPFKSPMENIGMQDSLLSRFDLIFVLLDEHDADRDADVAGHVLKLHTYRTQGEADGTVLPMGGGVETISTVNMETKKASSSIYEENTQWAGIQNKKILTMEFMRKYIHLARAVQPKLTDETTEYISEVYADIRSFDITKTDQERTMPVTARQLETLIRLSTAIAKARFSKKVEREDAEKAYNLLHFACFKEKPKARQEYEKKKRVPRHEGEDEDEQSDDEPEEMNDEPGSSSVPTAATPRRGVRRRAADDDSQSSMNDTTVTESQPTAKRARTGPAAIGIDRYKELKKYVRKAFDDIGSTDDMVDLHIITDSIQTQAGSNKFTDDELTAGYEQLENDNAAMIADDKITLI
The following text describes a protein:
Function:
This enzyme is an effector of phosphinothricin tripeptide (PTT or bialaphos) resistance. Inactivates PTT by transfer of an acetyl group (By similarity).
Sequence:
MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFSGHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQEALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGRELS
The following text describes a protein:
Function:
Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.
Subcellular Localization:
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.
Domain:
The PH domain does not bind phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members.
Sequence:
MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT
The following text describes a protein:
Function:
Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface.
Subcellular Localization:
Cell projection, axon. Cell projection, dendrite. Cell projection, growth cone. Cytoplasm, cytoskeleton. Cytoplasmic vesicle.
Sequence:
MASQSDCCVKVALRVRPQMANEKIEGCHVCTLVTPGEPQVLLGKDKAFTYDFVFDLDSEQHLVYQTCVYKLIEGCFEGYNATVFAYGQTGSGKTYTMGTGFDVNLGLQEQGIIPRAVHQLFEGIQSRRLRAQQAGVQAPEFKVSAQFLELYNEEILDLFDGTRDPESRNRKSNIRIHEDATGSIYTTGVTSRLVHSEEELLQCLKFGALSRTTASTQMNAQSSRSHAIFTIHLCQMRVCQQLQMNGGGETGELDGVNGLDSNPIAQPEYETLMAKFHFVDLAGSERLKRTGATGERAREGISINCGLLALGNVISALGDQSKKGGHVPYRDSKLTRLLQDSLGGNSHTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVVVNQDKTSQQISALRAEIARLQMELMEYKAGKRVACEDGSEGYSDLYQENTMLQRDNDTLRLRVKAMQETIDHLNSRVTHLLANEVSSLLTKSGQGNEEIGTLIQNYIREVEELRTKLLESESMNETLRRQMARLSSRSLFPDSSLSPAPGHPPGSSPVPISMEAEMTDVLRRAKLDIERLKKKERRQRRMSPELEKGLKKRVKLHTQENGESRQSGENGQNGEIDSDDNYTEDVMSPLQEESGCEEDEDEEEGRDEEEDFDSDESLVDSDSDSDEKANFQADLADLTCEIEIKQKLIDELENSQRRLLMLKLQYEEKLILLQNKIRDTQMERDRVLQNLMSMENYTEEKANKIKQEYEKRLKEMNRDLLKLQTAQKEHARLLKNQGRYERELKKLQCEVNEMKKAKVTLMKQMKEEQQRRRMVEAKRNREIAQLKKEQRRQEYQIRALESQKRQQDLVLRRKTQEVTALRRLAKPMSDRVAGRVARWNQTPSVTDSGADLSASTTASSSEPESARTVSGLVRQWNNKNNAYGYLAESEGSVDGTRVIGRKKLQHKPAGLGSTAAAGRPSFSKSARQKWQTLERRIMDIVMQRMTISNVEADMDRLIKKREELTVQQEALSHKREVLMADGEGPEAEDRLLLEVSEELEVLNANIDYINDSLSDCQATIVQIEETKDELDSVDTSVVISSCSLAEARHLLDHFLKASIDKSLQVAQKEAQIRLLEGQLRQTDVIGSSHNHMILDALREKAEYIPELQALIHNVQQENGYASTDEEPSEFSQASDSSVSQMKESNSQDDFKTKMEPRLSAQMKAVSAEYLGPILDPLTGSKAQHITKSLASLTDIQEDGLSLIPGSPGLNLSLRDYYHRDRASRTISLPVRGHTFPRQSRGYETSPITRRKSYDRAYRPTDGYTPPSSPPLRSRNDRNVFSRLTSNQAQGSALDKSDDSDSSLSEVLRGVINPIGGVKGGRTAPLQCVSVAEGHSKPVLCVDATDELLFTGSKDRTCKMWNLVTGQEIATLKGHPNNVVSVKYCPSSGLVFSVSTSYIKVWDVRDSAKCVRTLVSSGQVISGDACAGTTTRTINFSQGECQINQIVLNPSGSLLYAAAGNIVRMWDLNRMQATGKLTGHIGSVMCLTVGQSLLGKDQVITGSKDHYVKVFDVAEGTLGNVGPAHNFEPPHYDGIECLAVQGDVLFSGSRDNGIKKWELEQQELTQQIPNAHKDWVCALAYVPGRPMLLSGCRGGMLKVWNVDNFTPIGEVRGHDSPINAICTNSRQIFTASSDCRVKLWSYVPGLTPCLPRRVLAIKGRATSLP
The following text describes a protein:
Function:
Transcription factor which promotes stress survival and delays aging. Required for cell cycle progression and development of the mesodermal and endodermal embryonic lineages. Required for normal T-cell polarity, for correct migration of QL neuroblast descendants and other cells, for embryonic patterning and for the embryonic expression of hlh-8. Also required for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development.
Subcellular Localization:
Nucleus.
Domain:
The SANT domain and GATA-type zinc finger are required for conversion of the Y rectal cell to the PDA neuron.
Sequence:
MSRFDSQCSSEDVNKEDECVPSSSEDSQDGVSSPMENDDEPEFSQKHYDIEPCYYSLTGKSDRNCRGIVYRYRQDSDLKGFQSHDGTLYRLRDSVFVEVSQNEPYVIAAICGFKYTKRDHVVVKLTRYFRADDIPEISLNLMKQERAELEINPHLCPQSLNRELFNSELQITQPVSCLRGKCIVEYVKDVRHARTVADFSLDNDTFFFCLHYNQDSTKLASTHYAIRVGTSFQATLPPMAECSVGDDSDRDELLYRPNSIESGEEEDYIKLARCYRTYTLSGNHMLDSQKNARSLQVSDLLMDEAIIQLHRSGYKIDDALSELNANDIILTTDVDNMTQDDAKKFAKGIKQLGKNFSRIHRELLPHHSREQLVSYYYLWKKTPEATKPKQAARRVNPTSIKRPTKEKVKASRPTSTEYLDFDSASESDVENNGPSGRACHHCYGAESKDWHHANGLLLCTDCRLHYKKYGQLRQIANRPSQVPACLFKRSNSDEEESGVRTRAGKKEQRRRTPSSMSETPDRRSPSTVSNGAPNLTAEETPTKKLNGSVKRAPKRPLHNGVINNVEKSNSSEEPASPTTPPPTLTNGLTNGHGPESSTPNGETISKRMKVEPSYDDDDDEEEGKMTIDEGDDDPMPVLNGFKKEESVEEIKLELNGTIKKENGVETDPTTPTCSMEAENEVCETPAVVSVEIRDETNGETNSDLKDDENVEPDSPEDTFELGSNVEFETKNAMFVRSIVRSCGPRCARTDLIFKIKVGGVWEKSIKEKEERKKVHLQNQRIQDSEKVAIQQNQIKKEQQQSQPTPQQIHQQQAQQNAQHLQQLQQAVMLGHLPPEVLRQMMPPQFGVDPTAILMQQMMAGQQSQGVNAAFQHQMALQQQLEAHQVQFQLMMAHQHQQKMIAEQQQQQRHAAAQQLREREQREQRERERERQHQQQAQQALHQQQQQHAAAAANQLNPAMMQMMALMANSAASQQDIARLMEMAAQQQQQQQQAAQAQAQRDQERERREREAREREAAREREREQAAREAAARDQAAREHAQAVQAAAAAAQQAQALTPDMQHMHLLQQLMLNPALMMQLQQAQAQQQQQQPQVTNPLQMLQHGMAAQSANQAEMMRRIHPEPAMRPQHQ
The following text describes a protein:
Function:
Transcription factor that regulates gliotoxin production and contributes to virulence.
Subcellular Localization:
Nucleus.
Sequence:
MATAMQDVSPSFTSSPTSTMTTISTTTAATAAAAPKPDKPRKLRSACDACHRSKTRCSGGNPCTRCHEYMSPCTYSYSSRCGKPKGARSRKTLEREQRVAAAAESARIAGNPSALASLPATSTCTSTATTAAAAAAATTTTTIATTTAPSQGPAVDSAAAAAAATTSTVASPRADDCLGLFDDDEESNPFFSSGSENTGGTSFSPDWIPPLPSISDSDLSFPLLESCLGPDHDCNDSLFWSTTAEPDCQPTSKEPLDPRSKLLRSCKCLQTLSSLTARDIRRFDATFVFVRNYARAFSAFYHCSHCPKDAGSISMAVTALQLATTALEKTATAGTDAAGFKSGCSGMTAADLDEDLLTPGAEFFLPANGRGASNPAFQLGSYQIAPLPGEPDLEEHSEILNILIRSAVRRLLAVCWQIWDLLRGPASRDGRGHVFEPYDPSSSSSSSSSSFSSGPEIHQLCDLSCSAEAAQFRSTLVQIPARLCNLLAL
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSAPSLVQAVAKRGWLNKMLKPVSNWYINAAGYRQMGLRADDLISEENETVLAALQRLSPKESYDRIYRIRRATQLSLTHKLLPKNEWTTQEEDVPYLRPLIDQIEAEAAEKDALDTLAVVKN
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLSPEIINVWPHNLMSEFIRINNCASLFPYVSIDTEFPGTVYHQTNIPRHSLETLSPTEFYAVMKRNVDALKLIQLGLTLSSSDGRSHCSWEFNFRDFDSDRDLQNPESVSFLKRQGIDFLKNKQQGIESWVFALLFRRYIAGKELKWATFHGPYDLGFLIKILTGMELPESLDGFMMLVRGFLGYEVYDLKNVVRVFGLGGGLEGVARSLNLERVTGKRHQAGSDSLMIIRVFFELKGKCSEEEMNRVLQRFKYKLYGLS
The following text describes a protein:
Function:
Binds weakly to specific single strand RNA (ssRNA).
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MTAIRVCSRKFPTFASIFFQNITRNPSIHRISFSNLKPKTLLHPIPPKPFTVFVSRFHDGRPRGPLWRGKKLIGKEALFVILGLKRLKEDDEKLDKFIKTHVFRLLKLDMLAVIGELERQEETALAIKMFEVIQKQEWYQPDVFMYKDLIVSLAKSKRMDEAMALWEKMKKENLFPDSQTYTEVIRGFLRDGCPADAMNVYEDMLKSPDPPEELPFRVLLKGLLPHPLLRNKVKKDFEELFPEKHAYDPPEEIFGRC
The following text describes a protein:
Function:
Can digest both p-nitro-phenyl-alpha-D-mannoside and high mannose oligosaccharide (Man(8)-GlcNAc(2)). May be involved in sperm maturation. Has a possible role in specific sperm-egg interaction since sperm surface mannosidase acts like a receptor for mannose-containing oligosaccharides located on the zona pellucida.
Subcellular Localization:
Secreted. Note=Found at the sperm surface as a 27 kDa fragment.
Sequence:
MGPHSWLPLFMQLALLGPQWALHFYKVKVFVVPHSHMDVGWLHTVQESMQVYVPDVYNSVVEALTRGKRRRFIAVEQEYFRLWWDGFASAKRKQQVRQLLAEQRLEFVLGGQVMHDEAVTHFDDQILQLTEGHGFLYETFGIRPQFSWQVDPFGASATTPTLLALAGFNGHIISRIDYDLKDTMQHTQGLQFVWRGSRSLEARQEIFTHVLDQYSYCSDGFMWNGSPRFPDRPFDMDYSAVEMPVSQDSMNHYVLNLVDNVNKRAAWFRTQHVLWPWGCDRQFFNASQQFANMDRLMDHINKHTPELGISMQYATLAEYFQAVFAQDVSWQVRDHRDFLPYSSAPEQTWTGFYTSQSGLKRLARRASALLYAGESLFTRYMLSAAHRFLDPAWALTQLQQLRWAVSEVQHHDGITGTHILAVRDMFVEHLTTGMAGVRKLMDSIAQDMPLTHSGPEPGGHVAMVYNPLAWTVTTVITLTVSFPEVSVTDESGRPVLAQVQDSKETPSAYDLHVLTTIPGLSYQHYIIKPIRKAREDSQEAAATVPSTIQFGLKLRRQDGQVGRNLVPVKNSCYTVFLDKDTNLMHSIWERQSNRTVRMSQEFLAYRSVYGYEEAVTSDNYLFTPNGTAEPAWAAVRMEVVEGQLLSEIRQYFYRQANDSDHTYAIYSRLAHGPQDSAGELLCHRIEQEYRVGPLELNHEVVLRTSTSLNTGLVLYSDNNGYQMQRRTYRHDRNNSVSLNYYPMAQSAFIQDGGSRLVLLSEQAHGVSSQGNGQVEVMLHRRLWNKLEWTLQYNLTHDVTSVVRPVLWLLLGPRTLTTGLRQRSGLELQHRPVVLFRELGGTVQNGPGPRKQEPVTLPPSLHLQILSIPGWKYSSNHTVHLKNLQKGHYRRAKADFRRVLLRLHHLYEAGEHQALSRPVTLNLQSVLRGLGSVVAVEERSLTGTWDVNSLHRWSWKTEDGHHHRGSSRRPLPPLRGPNVTIHPKEIRTFFIHFQEQ
The following text describes a protein:
Function:
May act as a guanine nucleotide exchange factor (GEF).
Subcellular Localization:
Cytoplasm. Note=Concentrated in the perinuclear region.
Sequence:
MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLAKVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLALKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAELICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLLCMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTGGVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEASPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL
The following text describes a protein:
Function:
May play a role in axon growth and regeneration. May be involved in epidermal cell adhesion and epidermal structure and function.
Subcellular Localization:
Membrane. Endosome. Membrane; Lipid-anchor. Note=In neuronal cells, associated with GPI-anchored cell-adhesion molecules.
Sequence:
MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKISAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLIKNATGAQV
The following text describes a protein:
Function:
The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
Subcellular Localization:
Mitochondrion.
Sequence:
MLSRGTSYDYFVQIFNINIFLFKMYMRSIFKLRQAFSVLTKYTKDHEWIKYDTQTKIAKIGITDYAQNELGDIVHVDFQKVGLLFKTHQSLGAIESVKVAADIYAPVAGEIVGINEDLKDSPNLINEKAEETWILQAKVQNESELDTLLDKQSYEKIINK
The following text describes a protein:
Function:
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Involved in the maintenance of ribosomal (rDNA). Required for efficient fork arrest at the replicaion fork barrier within rDNA. Involved in the maintenance of mitochondrial (mtDNA). Required to maintain mtDNA under conditions that introduce dsDNA breaks in mtDNA, either preventing or repairing dsDNA breaks. May inhibit replication progression to allow time for repair. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. May have a role in conjunction with DNA2 helicase/nuclease in 5'-flap extension during Okazaki fragment processing.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Nucleus, nucleolus. Nucleus. Mitochondrion.
Sequence:
MLKYCRQLKTLHALQVRGTIHAGSKSYLVMKNRLEGSWAFNSDAKRFKHDGSMVQELEGEGKRGNASVLEEAWDTSGDDDILQHIAALEERRGEPDPSMCSGVASGTRLEVQMQRTEAEIKQSKEAPEPLIELPDVQILGSKTVDSKESIKNSAAGTQELAFLTQRPTLHEHISADQPQASDQRPSASPKRVQCFMLSDEQRNVLKLAEEGTNIFYTGSAGTGKSILLRELIKKLKTVHGRQGAVAVTASTGLAACNIGGITVHSFAGIGLGNSPKENLLKKVKRSRKHVQRWQNCKCLIIDEISMIDGELLDKLDYIARKIKKSKAPFGGIQLILCGDFFQLPPVTRDNQQPNFAFDSEAWKQAITATIVLTRVYRQQGDTKFIQMLNDMRLGKISEETEAEFRKLSRPLVTDDIIPAQLFSTRVEVERANGSQLAKLPGKRRAYNAIDGGDLSDEELKQRLLANFLAPKRLELKVGAQVMNIKNFDDTLVNGSLGKVIDFIDEATFMFYQSVRDDDLDVAEWEKYRDALAKNDWNAPELDEDEEPKKETRTSMVKKALREKFRTIDTDDTVDHLGDTIFDFLKDDREVTDPEVKANLERKKQLLQEVHMSSKGKKLPLVQFFQPDNTTRTVLVREEAWAIEDENEKPLVTRVQLPLMLAWALSIHKSQGQTLNKVKVDLRRVFEKGQAYVALSRAVSRGGLQVLNFDKEKIQAHSKVVEFYDSLVSANDAVKMRKDVQRKISFPITKSKAPNAPTLPLAPQLRGNSIITLLERSNKNSGRSLSQKFSYVPSQSNNQAPSP
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response. Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response. May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAEKRRPLLGFVGKLPSGTTAGNSGKTHCPLCMGLFKAPRLLPCLHTVCTTCLEQLEPFSVVDIRGGESDTSSEGSVFQELKPRALQPQIGILCPVCDAQVDLPMGGVKALTIDHLAMNDVMLESLRGEGQGLVCDLCSDREVEKRCQTCKANLCRFCCQAHRRQKKTTYHTMVDLKDLKGYSQIGKPILCPAHPAEELRLFCELCDRPVCRDCVVGEHREHPCDFTSNVIHKHGDSVRELLRGTQPHVEALEEALAQIKGTNSAVQERVKAVAADIRTFSEGYIKAIEEHRDKLLKQLEDIRVQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKGVVVERLTKLNKVEYSAHPGVNEKISFSPKQKAGLCRGYEVYGAINTKEVDPAKCVLQGEDLHRAREKQPASFIVLCKDATGESMGRGGDNVQVTVIPNDKKDSPVKTMVHDNKDGTYYVSYTPKEPGTYTVLVCVKEQHVQGSPFTVTVRKRHRSHPGVFHCCTFCSSGGQKTARCACGGTMPGGYLGCGHGHKGHPGRPHWSCCGKFAEKSECTWAGGQSAPRSLLRTVAL