lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Catalyzes mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and thus decreasing STAT1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to IFNG stimulation. However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703'. Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription. In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation. Mono-ADP-ribosylates PARP9 (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=In steady state cells the protein is mostly nuclear. A minor proportion is detected in the cytoplasm. In macrophages, mainly localizes to the cytoplasm (By similarity).
Sequence:
MAASGSFPLLVEGSWGPDPPKNLINKLQVYFQSRKKSGGGECEVVPEPGNPARFRVLFSPEDVRQNVLERGNHELVWQEKGTFKLTVLMPTDPEEASASKKSRKESPEEESKTKEDAVKQGDLDITHSPSSGSEKTEDVPKECENISSMVAFENLPEKVSEMVLTILVENISGLPSDDFKVEVNRDFAVAVVTFQKPIDIKKFIVDCISHRSNQQLQLAPRLLETTNVVRVENLPPGVDEYQLQLFFENPFNGGGRVARVECFPEESSALVEFCDSKVLDTVMAKTHSYNKMPLSVFPYYPSLGTALYGEEKPLIKLPASFQESLDLPLWKFFQKNNHLIEEINNEMRCCHCELTWSEINGKLTIRPAATLVNHRLSIKTWQRDASAVLSGIKSKYGVELFEVCSPVWDIIKHELESGDDRVLVEFEKESLNIAGKSEDVQGMSQKIRELIESTTEKLRREEQSLKEKVAISPGKHYLLHHSGFLKDLSKGFPEMEISYDATAQFLYLKGFRADVYKVKCDIQEKVFSMAQKDVQVSSEVFEFLQQVDSQRLSKSLFEAQNILAIYELKGTALFLVGSSFKDLAEAETKMLSALSHKQIEVEDKEVLISNGWKKKVHPLQKRHSSCATIIVQNELTSETPAKVIVTGCVKEVNEIHRQLFEYLENNMKVERALKIKPSLIVDYLRTDKRLLSKIKKAHVYVHFKPKDNPNSILLTGCKSKVLECMNLVKEIQDSVCVQRFQTDKAGVRHFFKDKESYYKTEIGRQFGCVIELEEDREEKGEEEDGEEEEGEEEGESSINEQKCHLQRDIAPGVKLFVLEEDLSRFPVDVVVNAANENLKHISGLAQALSKAAGPELQTECDQIVKEGGVVLPGNAVISKAGKLPCHHVIHAVGPRWKGDKVLECVSLLKKVVRQSLSLAEEHRCRSIAMPAVSAGIFDFPLELCVANIVSAIKEHFQHKRDTHTLKKIYLVGLPAKVARAFAEAVKTTYKDSLSHTAFPSSLKALVPLGKTPQKQGSLLVSPEGLRIRLVEEGVQNATTHAIVNSISPDLKLNKGPLSQAFLEKAGPKLQEELTRSGQGVSVDVGTILQTSGCNLNSRHVFHVVPPPWKSNNSAWSLKIMKNIIRDCLKTTENLSLQSIAFPAIGTGNLRFPKPEFAKLIISEVLKFSSRNQLKTLQEVQFLLHPKDHENIQAFSDEFDKRNNGDPSDKNPKAEDTQGIYGSLSSPTLGMHEMNIGPILFQVATGNIIKEVADVIVNSTTLTFDLKSGVSKAILEGAGQNVEQECSLLAKQSNHGYIVTGGGLLQCKNIIHVVGGNDVKKSVSCVLEECEQRNYSSICLPAIGTGNAQQDPNVVAKAIIDAIEEFVQKKSVQAVKRVKVVIFQPHILQFFYDNMKEREGSPAPPKQSPAKQSVMSKIASFLGFPKQASPKKNTLVLEKKIEHTVFQVCGSGVDSVNKTISWLKELITKEQLSYTNDDECVSDFDMEEYEKLNEIQKELNITIEMNQKKTSIQVSGISRDVIKARDEIEGMIKSIRLAKEKESQADYISTYVEWQYIDKNITQCFDKMTNMKLEVAWKAKKKDTVVQIHNQDFTVDLSTNTATAPQGQTFTVQRLVKAEAEIPANWSDMKQDKLLLVNLQTSDPEYNMVASAFRQTCSNFFIEKIERIQNPALWRRYQAYKKSMDEKNGNVRNEKHLFHGTEASSLPQLNSNGFNRSYAGKNATAYGKGTYFAVKASYSACDTYSRPDTNGRKYMYYVRVLTGNYTNGNASLIVPPSRDPQNAADLYDTVTDNDKNPSIFVVFYDNQTYPEYLITFRQ
The following text describes a protein:
Function:
Has no ubiquitin ligase activity on its own. The heterodimer with UBC catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. May play a role in the control of progress through the cell cycle and differentiation. May play a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Sequence:
MGSEEEKVVVPRNFRLLEELERGEKGIGDGTVSYGMDDADDILMQSWTGTILGPHNTAYEGKIFQLKLFCGKDYPESPPTVRFQSRINMACVNPENGVVDPSHFPMLSNWRREFTMEDLLIQLKKEMMSSQNRKLAQPLEGNEEGRTDPKGLVVKCCVM
The following text describes a protein:
Function:
Transcription regulator. Acts as a histone chaperone that facilitates deposition of histone H3.3. Has a role in chromatin remodeling together with asf1 and XNP. Has role in the transcriptional apoptotic response to oxidative and UV stress.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Chromosome. Note=Localization to the nucleus is regulated by dj-1beta and oxidative stress. Localizes to pericentric heterochromatin associated with chromosomes X and 4.
Sequence:
MSASVICVDLSSESDEESPAKRRRLEDPLRLLTPSGRQSFPAKLLNIPKASLGSAMVVPVAETGPARETPVIVDPLRSMHIPSGITITKHQKNVLATNGNMNLSLAESNNNNNTTSLNKNVTPKQINVGTGQKVAWSVSSKAPSPNAVITTVPSHQVRVTPFNPIRLAPGSKIIPASNAMPAKIQPILGMGQPQQQAQAQQPKAIIVGFPKPNTAVAQMAQHQKPLTLQIHQKLIAGQQQHIASISQLQQVSLQQQQPLRPVSIQLQQQQNQRNGSLPGKQQKPLECPVPAQQEKLPRGPLPTKPAEPLSGPLPTEPDEPLGGPLPTRPKPPVRSLQQPVNKNTAIGVQIQQSQEPLGGTLPTRQKPLGGQLLTQQKPPVGSIQQSVKQNTGIGVQIQQIPKVVVGQQPQKVYLNKLQQEQQKIFLGHLQQQQQKTFLGQLQQEQQKILGQLQQQKQQQQQQQKKILGQSQQQKVPLGQPQPQQKLPQQLNNSLVQLQQQHQQRTSVGQLQQQQPHQSQQKNSMVHVKQQPQQQKKISVGQFQQQPQQQQKTSVAQLQQQPQQQQKISVGQLQQQSQQQQKPSVGQLQQQSQQQQTPLVGQLQRQTQQQQKTSAGQFQQQPQQQQKISAGQLQEHSQQQQKTLAGQLQQQAQQQLNTSAGQLQQQQKPPKASLAQQAAAQKQGAGLGQQQQFQSQPQQRTSAGLLQQQQMPQKKIVMQPQLPKTSVVLPRPQQLPKNPLLVAQQQSPKTPLVNSVMGPQFPSQQPSLPVVNQITHKSMTIQRLPMLQTVQKILPKQIAPQQTPPPAHIVQKQTMPNAAMQNPPFAHRPPIVRPMTVAKISPVPTNNKVCIPMKPQMASYVSPTDPTMTAARTLPFRSSQRKTSEAPMTSTHVQGFTASATPPQRLLATPPHCAAALNEPLLLNLPPTTSITPQLTPTTTPPPAGPSAAVQQQQLAKAAAIKLNSLPEASISPVNRSPTASAKRIQPITVLKKSDEEWQRHLEQQQQKKHVQLQSSSMTTIVLVESPPTTPPTDKPEPERGPMTVEKSSIKPMATDKQSRAIKRPAVMISTKKSGLVVTEIVDLDEIPDIPPEKRGKECFPPIKNAAKAAPSVNAPFTTEYAALLRLCREVDKSTHMERLVKGELTQYYYSAPESFVMSCGFRNLVTMAMARIRSESYLVYVHLKYVLDELASRRLTKMFPTVRAIPPASQFPLPPASQFPLPPTLTTPKQPAIVKAPGQQTVMAGREQDDEVEEVTLVNVGTVSCEERRRDERIRHFYRTLHAITKRIKMLEEAEVDLNDEDSSYLQLERFKKRACQIYEKICDLKGESKSVRRQLKKPIHFKDSDYPHFNNSLSAFVNRMQDFPDYHDVLQILEKCNKEKELGLAKYEMKRIAYDAFNKVGRMLQSRRKNDLYETVTHYTANGKDPASSDPELLAKLKENNKKQTKISDILEKYALEQDLNAEERQEARLKEKKLKQVKADEEAAKLAALAEDDDKPCTSAQAAAKAAALAALKRGPAARGNVIRKKRAANGRIFKIADDGDDSEEESDSEDDDVEEFVNNFQANSDVSDADSEVEAVTSPKRDALPLAEEEDVIDITRDETGKKNDEGTPNGRLKIMSVSSLNANFVHGQDLHRKPNPMPSAKPVIADQIIISDEES
The following text describes a protein:
Function:
Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. Isoform 1 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Following G-protein coupled receptor activation, undergoes liquid-liquid phase transition, associates with (1) cell adhesion molecules that are expressed at the surface of adjacent cells, as well as (2) PDZ-containing proteins, such as SHANK3 and DLG4, in the cytoplasm to direct synapse formation.
Subcellular Localization:
Cell junction. Cell projection, axon. Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MPEYTAMWPSQLLIFMMLVAPIVHGGKHNERHPALAAPLRHAERSPGGALPPRHLLQQPAAERATAHRGPGPRGATRGVRGPGSQGAQSAAQAFSRAPIPMAVVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYIFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLTEYSSKDDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIEGTWDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNSYQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRSGQAHHGQVSYISPPIHLDSELERPPVREISTAGPLGMGSTTTSTTLRTTTWSQGRSTTPSVSGRRNRSTSTPSPAVEVLDDITTHLPSASSQIPAQEESCEAVEAREIMWFKTRQGQVAKQPCPAGTIGVSTYLCLAPDGIWDPQGPDLSNCSSPWVNHITQKLKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVGLLDVQLRNLTPGGKDSAARSLNKLQKRERSCRAYVQAMVETVNNLLQPQALNAWRDLTTSDQLRAATMLLDTVEESAFVLADNLLKTDIVRENTDNIQLEVARLSTEGNLEDLKFPENMGHGSTIQLSANTLKQNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTEAMSTNHSVIVNSPVITAAINKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYWSTQGCRLLTTNKTHTTCSCNHLTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNINYEDNRPFIKSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGKCLRTHCCSGKSTESSIGSGKTSGSRTPGRYSTGSQSRIRRMWNDTVRKQSESSFITGDINSSASLNREGLLNNARDTSVMDTLPLNGNHGNSYSIASGEYLSNCVQIIDRGYNHNETALEKKILKELTSNYIPSYLNNHERSSEQNRNLMNKLVNNLGGGSEDDAIVLDDATSFNHEESLGLELIHEESDAPLLPPRVYSAENHQPHHYTRRRIPQDHSESFFPLLTNEHTEDLQSPHRDSLYTSMPALAGVPTAESVTTSTQTEPPPAKCGDAEDVYYKSMPNLGSRNHVHQLHTYYQLGRGSSDGFIVPPNKDGTPPEGSAKGPAHLVTSL
The following text describes a protein:
Function:
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MINKCGRERFEEIEKVSPKQKKIKTKTHSIKNYHQPLNTHISVIMSELSSFLEKKVHVITSDARFFEGILEGYDKSTNIILSNCIERIIYSKDDEEGENQEIPLGVYIMRGNEIVCVGEIDDELYKSINWETLKGHALKSTKNPLK
The following text describes a protein:
Function:
Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MTQKKVAILGAGSWGTGLALVLADNNHKPVIWGNLDKIVNEINESHTNSHYLPDIILPTEVKATLSLDEAIDGAEIVVIAIPTNAMRIVCKQLNEALKEPTILVHVSKGIEPETNLRMSEVIEEEIDAAKRKALVVLSGPSHAEEVALRHPTTLCASCKDLSAAEIVQDRFINNNLRIYTNDDVIGAEIGGALKNIIALGAGISDGLGYGDNAKAALMTRGMAEITRLGVAVGSNPQTFYGLTGIGDLIVTCTSVHSRNWRAGNMLGKGENLDEVLEKMGMVVEGVRTAKAVHGWAKKLDIDMPITESIYAILFENKDAREAVDLLMGREKKIEKESF
The following text describes a protein:
Function:
Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Subcellular Localization:
Mitochondrion.
Sequence:
MLGRASRAARRRTSLGSRLARTASSSPCEDAVLTREFIYASLYAKEAGYFTTQQREVLHAPTQSIDFGNLWGAGEYRNVVAQLYKESPEAWLTPVEVFVPHYSQALARYMLHSPFCGQDLEIYEIGGGSGSNALHILNFLKQHAPDVYAKTKYTLVEISPVMAERQRQRVAASHPQQCTVINQDILTFADMHKPVKTQCFFLALEVLDNLPHDKVTLQNGKWFETIIKIDAEEEDQVLQESMRPVKDMLIRQTLRYFGCELPLRVSYKNKTGLAQRVRRMLGKDDPVLHSAFVPTGAMQLLNTLRSAFPKHHLIAADFDSLPAPNLDDNSPVKAIEHPLSPTATSSGTLFAGNAPLVASKVTGVTKDHDTYLVQGGIADIFFATDFDKLKKAYCSALQRQPDEVSVVKSADFLKEFADVQKTKTITRYNPLLEDYSNTSFILS
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
Sequence:
MDAAAAMAAGGGEEEEDKARMEAVADKLQTRDAIRLYNWVSHRCFSDCVTTFYRRTLGKKEEDCVRSCVRKFLLLSSASAARFAHLADPSSAFDD
The following text describes a protein:
Function:
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MSDEGDVADEAVADGAENADSRGSGGRTALVTKPVVRPQRPTGKRSRSRAAGADADVDVEEPSTAASEATGVAKDDSTTKAVSKAARAKKASKPKARSVNPIAFVYNYLKQVVAEMRKVIWPNRKQMLTYTSVVLAFLAFMVALVAGADLGLTKLVMLVFG
The following text describes a protein:
Function:
Functions by promoting the formation of the first peptide bond.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKEQKEVRDLQEGNYVMMEDAACQINAYSTAKPGKHGSAKARIEAEGVFDGKKRSLSQPVDAKIWVPIVNRKQGQIVSKESDTVAQVMDLETYETVTMQIPGELDIQADENIEYLEFEGQRKILQE
The following text describes a protein:
Function:
Directs RNA polymerase II nuclear import.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAVIRIKRRLEDEPSDTLILNCKKRKTEADTQDQDAELSTILKFAGTVKNQEDTLSHIKKPTKVELEDQFKKHSTDLSSKLRLQKQEDSKKNRYKVVNCFRSQSANLEETNEPKAEYTIYDIETENHDQISKDSDQNYVYDLYYTTSDDLGELDDYVSMYPYNDVFMYGSVRDNGLKEADSDDDSEDSNAENFWKNDYPDESDMESVTEEDMLQAMKKCDLSDLSSDDGEEGFVYSIDSEGAGFEEDVDDSDVQRYGERYARFKAKHKKNVQTTALDHDLYYGDIDEEEFYY
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MSATKVKRRVGKYELGRTIGEGTFAKVRFAKNTETGEPVAIKILDKEKVLRHKMVEQIKREISTMKLIKHPNVVRIYEVMGSKTKIYIVLEYVTGGELFDTIANHGRMREDEARRYFQQLINAVDYCHSRGVYHRDLKQIKDDGLLHTTCGTPNYVAPEVLEDQGYDGAMADLWSCGVILFVLLAGYLPFEDSNLMTLYKKISNAEYTFPPWTSFPAKRITIPEILEDEWFKKGYKRPEFDEKYDTPLDDVDAVFNDSEEHHVTEKKEEEPVVLNAFELISRSAGLNLGNLFDSEQEFKRETRFTSKCPPKEIVRKIEEAAKPLGFGVQKKNYKLRLEKVKAGRKGNLNVATEILQVAPSLHMVEVRKAKGDTLEFQKFYKNLSKTLKDVVWKSEDLQMQPAS
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It thereby plays a central role in histone code and gene regulation. Required for the expression of Notch target genes in development by affecting the levels of Su(H) in imaginal disk cells and stimulating the Su(H)-mediated transcription of Notch-specific genes.
Subcellular Localization:
Nucleus.
Sequence:
MSKRSADDATGSSCLVAAAAAGQPPIKKVHFEPHLIGPVSTLEEMDIKVLEFQNKKLAQRIEQRMRTEAELRHRIEQLEKRQTQDDAVLNVVNRYWNQLNEDIRVLLQRFDAETADELENRNENEVTTSFLAQLSTWDKEELDEKLANRVQVSKRAVAKIVQVIDRLMQRNEKITHVLKGDSLASAGSGSGAGAGGEEEQQQASGDAETTTSSAGVHALEETLKQTHIEIMSENHKLQNLNTSLHEKFHTMSLKMKEYQDAHTAKETENAELKNQIDELQYDLEKIHCRNDKLENHLAEAIEKLKAYHQIYGDPNKSTNSAKTPTTTGSGGATTSVNSQLLEELQKELEEYRELANNRLQELDKLHATHRETLKEVEKLKMDIRQLPESVIVETTEYKCLQSQFSVLYNESMQIKTMLDETRNQLQTSKNQHLRQIEVMESEELIAQKKVRSEMIQMEDVLALIRKEYETLRIEFEQNMAANEQTAPINREMRHLITSLQNHNGQLKGEVQRYKRKYKDTSTDNLKLRQELADALATLEGNKLQAATGAAGEEIKQENSTGVKEENSNNVSASGQTNQTNSGNDTNVAIKEENHISAEDEADDEASGKDVKDGIKQEKLSSGDAAAAEKKDSPGPGNSTSSATNSVPVKNEKDSKDGVKGKDVKAVESETVRDLKAQLKKALNDQKEMKLLLDMYKGVSKDQRDKVQLMATEKKLRSEIEELRQQLKKLQESKREERKKLADEEALRKIKQLEEQKYELQKQMANHKPTDNSWGSGAPGTANYTRPFVGSHEEEALLNEMEVTGQAFEDMQEQNSRLIQQLREKDDANFKLMSERIKANQLHKLLREEKTVLEDQMATATTQIEAMHIVLRKLEEKERSLQATVASIEKELMLRQQAMEMHKRKAIESAQSAADLKLHLEKYHAQMKEAQQVVAEKTSSLEAEAYKTKRLQEELAQFKRKAERMKKMEMSGTTIDEVMIEEIREYKETLTCPSCKVKRKDAVLSKCFHVFCYDCLRTRYETRQRKCPKCNCAFGANDYHRLYLQ
The following text describes a protein:
Function:
Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.
Subcellular Localization:
Nucleus.
Sequence:
MGKRKSTSAKTAPRKKAEKLDTTFCCPFCNHPGSIDCKIDLKHMVAEASCSACLESYSTTAHALTEPVDVYAEWIDECEKANADRDGDDDHPRNDDDEHYA
The following text describes a protein:
Function:
Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.
Subcellular Localization:
Nucleus.
Sequence:
MAKRKSMSSKMASRKKPAPKLETTFCCPFCNHPGGVSCTIDLKLYVASAVCYVCQEAYHTTAHHLTEPVDIYHDWIDACEKANEDVDDVDGHKRQRRVGSDDDDDSDA
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Sequence:
MNLTELIIDKRIFKLLECKKCNQSFISGFNKPLKTYQCYKPQFYCTDCIKEEYSYINEFCSLELNCPNRNKEIILDEADVNNSGCNEVVPIKQLRSHVNACGFQLVSCLHKECYGNYVMRKDLKQHNESYNNKIIQCLLCSEEMKRIDLDNHILEKCSEKSCICSFCLKPYIKKNQEAHLSLCQEVSIQCHLCNENIKRCDINSHYSNFYLHSKQIINNLIINENKNKELKEKNQQLENKIKYLENENEEIMKRLVSMERSFLKFKDSFKNIKKLISKKKGVWYIDNIDSQSMSYGLGSLAFSFKLSYSPYGSYIVSIEFEKYFDSPVLIDCTFNVIKNNSLKGSYIIFK
The following text describes a protein:
Function:
Involved in rRNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MANLKSARHRKAAYDSSLQLANALGAGANKIKKQIRNVERLLAKKRDTLPDTVIVEKERTLEALRLELASAEKRALARKNAKKYHMVRFFERKKATRRYKQALKKVETSAGDDAALTDLRQRELELCYVVNFPKTTKYIALYPVEEDPEAAKETAAKRDAFLKVVAKQLSEGTLPVPLEQILKGKKLNKESTGISVSDSEDEEEPGRNEEAHEEEEDDFFE
The following text describes a protein:
Function:
Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MATQQINKYTPVHWAIINNIPLKEEMLCHCNINDFDCYGIPGLHYAIHMQNIEVIQWLFDHGADPLLRNKNGFNAFQEAVCTRNEQIIKITYEKTYNYYETIYDERVIDGAETLNELHDFQFTLHWELQTWIPLGTYLLPSDNNVIRKRGKNLRLDMNIIGFSHYTVQKGNGSLIFFGEDKNQFKKGEVIFVNHNEKTVTKLCGCGTQRKLKIEDVLKTNVTTMKTKIIFDCKEAKTLLGYERNENINGINCKVYNVTPFWAELITRELPSIIQKPKHFKSKIYDDEYIQNHIKNNILLRKNEKEILRKKTCQAEMWIGKGSIELSEFKILMKFLSKNFDNFSAFEDFFERNNLTNDFGFPLQFKIPLAFSLSIVANIKDYQAVSPNEEIFEIPKAYNILDFTKN
The following text describes a protein:
Function:
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock (By similarity).
Subcellular Localization:
Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated.
Sequence:
MTLPVSDPAAWATAMNNLGMAPLGIAGQPILPDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVAKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERMRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANHFYSMIQSANSHVRRLVNEKATHEKEMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEETTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKAHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELDRIKDDNLQVEQLLENFHEKQENCGSRLCASSQEGEQPLEKTAVSNPVKSEREALLVGIISTFLHVHPFGASIEYICSYLNRLDNKASYQIPSKLTTSPLLPISTSDVESLMSRLQHTFRQEMTGVGASLEKRWKFCGFEGLKLT
The following text describes a protein:
Function:
Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MASLRSGPAWCRLLAWAALGPVLCGGSMQAEPEPGEEPEADPHARHLYSAEMLRHGAAAAPHFVMFFAPWCGHCQRLQPTWNDLGDKYNNMENPQVYVVKVDCTADTPLCSEFGVRGYPTLKLLKPGQEPLKYQGPRDFQALENWMLEKLNGEPSDPESAVEPPKAPEPKQGMYELSADNFKTHIAEGNHFIKFFAPWCGHCKALAPTWEQLALAFEHSETVKIGKVDCTQHYEVCSENQVRGYPTLLWFRNGEKGDQYKGKRDFDSLKEYVDSQLQNSGKEPPASKPTEAPQPPAEPTQAEQAAVLSLSEKDFDETIARGITFIKFYAPWCGHCKNLAPTWESLAKEQFPGLTDVKIAEVDCTVERNVCNRFSVRGYPTLLLFRGGKKVSEHNGTRDLESLHSFVLRQARDEL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEEPSPPSPEGGREPNETWGRRRVGIPGRMGPDALEEKNFSPDLQCQHFRCFRFHEADGLREVCSRLHSLCRLWLKPEEHTKAEMLDLVLLEQFLAVLPAEMERWVRECGAETSSQAVALAEGFLLSREQEEKALQGERLEKEVLQAQVFPLETSKKFPSECIELEDKTGESPLGDEPRVLRRCGSSTLSDAEEVASIQQDQVMFEDVAVHFSKAEWALLDLDQRALHWEVMEENYRMVASLGGDGQGSENGGAPNKMWLKTGRSKKVEERSLRMEAEGYNRKQCPVDTREITIQETIEERREMGNSPVYENGFFQEASSRHPAHNEKDKIVDKPYKCLERGKCYTEKNSLSKHQNTHREEKPYTCLTCGKSLVSKNSLIRHEMTHRGEKPYKCLECGQSYSDKRSLIGHEMNHRGEKPYKCLECGKSFSLRSSLKQHQNSHMGEKPYKCHECGKGFVSKNNLIRHEMTHRGEKPYKCLECGQGYSEKRSLIGHEMKHRGEKPHKCLECRKSFSLRDSLKLHQNTHREEKPYTCLPCGKSFVSKSSLIRHEMTHRGEKPYKCLECGKGYSEKRCLIGHEMKHRGEKPHKCLECGKSFYLRDNLKLHQNTHREEKPYTCLTCGKSSVSKKNLIRHEMTHRGEKPYKCLECGQGFSDKRNLIGHEMKHRGEKPHKCLECGKSFTLRDSLKVHQNTHREEKPYTCLTCGKSFVSKNNLIRHEITHRGEKPYKCLECGKGYSDKRSLIGHEMNHRGEKPHKCLECGKSFSLRDSLKLHQNTHREEKPYKCQECGKCFFQKAHLKSHERTHTHEKPFKCMECGSCFSNKRILLRHEMKHRREKPYECLECGKGFYEERSLIRHGMNHRGEKPYKCLECGKGFCWKNGLKLHHNTHTGEKRYKCQECGKCFFQKAHLKSHERTHTHEKPYKCLECGKGFSAKRILIGHEMNHRGEKPYKCLECGKSYSLKSILTAHQNSHKGESGKSMSYKSNLRNAQNSAIEDKTKESSLKAQEF
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body.
Sequence:
MFDAGLDPAAQLELQRQLQDERRNEIHAKYATAITNMVQAEAGICAVNRAKIQSIWRDRLRSVKKTELIKQIESLIQDFDHQVDRKDAFITLLSRYISIAEEQRRRCIRTHLSTMDGILALLQERSALFEESLEDNITRLQAQFDQEIAALKKSYDARERLLQEIKSSTQEQEDQLIQQLNSSYSSKISELKNQSQETCNVLRLNLEEINADLERHLLDAHEKYRANTDTKQHQFKVLLLKDQQSSLAIERQKQKIERLSKAIAHWRAKIQTTTEEFRAKNALLKKEKEATYLEFVELKKKLTAYRNSETGRMKALVLAAHEAEDRIISLKESANKIIRVSTLCTRLETEAERVNEVDRIDDETNRHINDECKHDEMVTTSYLNVGDNFLGKDAMVAVGELRSIYKKLSRVSIDRLALERESVLLERENRELREALQRFLSTSGMGVKK
The following text describes a protein:
Function:
Interferon-stimulated protein that positively regulates RNA virus-triggered innate immune signaling. Mechanistically, promotes 'Lys-27'-linked polyubiquitination of MAVS through TRIM21 leading to enhanced the IFN signaling pathway.
Sequence:
MEASNCFGKKRERERERMSLSDWHLAVKLADQPLAPKSVLRLPEAEQGDSSLGSYSISCLKQLIAGSLQESVPDPELIDLIYCGRKLKDDQTLDFYGIQPGSTIHVLRKSWPEPDQKAEPVDKVAAVREFRVLHTALHSSPAYRDAVFKMLGNKESLDQIIVATPGLSSDPIALGVLQDKDLFSVFADPNMLDTLVPAHPALVNAIILVLHSVASSTPLPGADASARGVPSSSYRDMPGGFLFEGLSDDEEDFHPSTRSTPSSSTSGSRPASLGYSGAAGPRPITQSELATALALASTPESSSHTPTPGTQGHSSGTSPMSTSVQSGTPITNDLFSQALQHALQASGQPNLQGQWQPQLQQLRDMGIQDDELSLRALQATGGDIQAALELIFAGGAP
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.
Sequence:
MGRINMSEMEKIQKNTNILEGQLTCKELLGFYDSEPSKSSMMKTLDKFNIKHSEKSKFQSGYGKVIAEKLQHCIKFDVGSNIDTRQLSERIIDYCIDNYSGHFYISTNTNVKGFALDPKGQIIGAMTSQGIILADYFVIAGAHKTKYLTDKLGIRVPIMPIKGWALGIRVPNDTFFKEYTFFTPQYFSTYVNNEIRLSCGAEIGSDFSKEIPSEEWGAKMGLKHFNQHFGFNINMDDCYVRHCYRPITPDDIPIISQVPVFNNVFISAGHGSKGMTYCFGSAEILFQILSGIKEYPEYNINRFYLV
The following text describes a protein:
Function:
Component of the glutathione system which performs several activities such as glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage. GRX2 is more active as an oxidoreductase than GRX1. Responsible for the S-glutathionylation of DHBP synthase.
Miscellaneous:
MISCELLANEOUS: Present with 31400 molecules/cell in log phase SD medium; MISCELLANEOUS: It is unclear whether the long polypeptide observed in mitochondria represents the immature form of the protein before cleavage of the transit peptide and release of the short form into the cytoplasm or whether two mature isoforms exists.
Subcellular Localization:
[Isoform Cytoplasmic]: Cytoplasm; [Isoform Mitochondrial]: Mitochondrion.
Sequence:
METNFSFDSNLIVIIIITLFATRIIAKRFLSTPKMVSQETVAHVKDLIGQKEVFVAAKTYCPYCKATLSTLFQELNVPKSKALVLELDEMSNGSEIQDALEEISGQKTVPNVYINGKHIGGNSDLETLKKNGKLAEILKPVFQ