lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Exhibits GTPase activity (By similarity). Component of the plastid division machinery that forms a contractile ring at the division site. Contributes to plastid division in the vegetative shoot apex, at the shoot apical meristem (SAM) where the proplastid-to-chloroplast transition takes place.
Subcellular Localization:
Plastid, chloroplast stroma. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein. Note=Forms a contractile ring at the chloroplast midpoint. Exhibits a dynamic trunover in FtsZ ring facilitated by ARC3-mediated destabilization.
Sequence:
MAAYVSPCLTPPDSRVLTVLRKSVLPDHHLGTRVGCLRMSEGTTKRYRVVASHKYESSSIRNSLNSHSTSHFQSQDSFLNLHPEISMLNPRKETSSVPITEDLDELSTPNTYNEARIKVIGVGGGGSNAVNRMIESEMIGVEFWIVNTDIQAMRISPVFPDNRLQIGKELTRGLGAGGNPEIGMNAATESKEAIQEALYGSDMVFVTAGMGGGTGTGGAPIIAGVAKAMGILTVGIVTTPFSFEGRRRALQAQEGIAALRDNVDTLIVIPNDKLLAAVSQSTPVTEAFNLADDILRQGVRGISDIITIPGLVNVDFADVRAIMANAGSSLMGIGTATGKTRARDAALNAIQSPLLDIGIERATGIVWNITGGSDLTLFEVNAAAEVIYDLVDPTANLIFGAVVDPSYSGQISITLIATGFKRQEEGEGRPLQATQADASMGATRRPSSSFTEGSSIEIPEFLKKKGRSRYPRL
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDELPSHEPKNRYSRSSSIGSPADARYAPPSPLHEPSDASQIAIAMGGVRQRSASIRKHRRQQPSQVFIPPMHENVTAPRDEHEPKMSSPVPETDEKPLLQTSAAGATLLIGIQILSKLASFGLNQMLLLVATPALFGANAQLEFVLNTVLFFSREAVRLALQRLTLAGKKPDVYVFGGGVVQDTVSGTSQAVINMGYISVLLGVFFSSVAAASHSLFSVAYASWAVQLVCIAAMVDLASEPYYVLAMQQLRFRSRAAAEAVAILVRCVVTFSFTLLAKDTDGGLNGGVLAFAFGQLAYSLISSAVYIYTVRQDNRDRQFSFRPQKIQPFESQMEMSDNNRDVITHNASPYYLDKPTVRLAGSIWIQTVFKHCLTEGDRILVSYFLPLYDQGVYAIVLNYGSLVARIVFFPIEEGLRTFFSNLLGEKPSETALKLSRQVLCSVVRIYTYVALFAAGFGPTTLPFIFGTLLGARGGQWSEGAPSRSAPAVMGAFALYIPFMALNGALESFVQSVATPADLRRQAVALGVFSVVFATVGGLLMKTMDLGARGLVFANIVNMTLRIGWSVVFIYHYYVSHKAENVNPTHLLPGKLVIATGVTTILASLFGVGRVSSFRDVGINIGLALALAAAIAVEERQALVQLVQLVRKKEDKVKVDDKEEKEKESDKSEGESE
The following text describes a protein:
Function:
Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MEVRSKDTLAPPLKHKHQEKLMVKKSQLLLHTSTWTINSTLTGKPRLANFSTGRTRKNLEEESGKVDDHIQAAVEKPGSQKYLLPHPIWSEEELDAVEVTHNPPKERVDKAAYFACKALRANFDFFSGFSWGKRTERKWIYRIIFLETVAGVPGMVAAMSRHLRSLRRMQRDHGWIHTLLEEAENERMHLMTALEIKQPSLFFRLMVLGAKQIITSTSIFVNMFFISYLVSPRFCHRFVGYLEEEAVITYTKLLKDLRADALPKWKDRIAPEISIKYWKLRPDADYIDLFRAIRADEAHHREVNHTLSDIKPDDRNPFGPGE
The following text describes a protein:
Function:
RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of pre-mRNAs. Associates with chromatin. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Binds non-specifically to pre-mRNAs (By similarity). Required for embryonic development, in particular of the brain.
Subcellular Localization:
Nucleus.
Sequence:
MVEADRPGKLFIGGLNTETNEKALEAVFCKYGRVVEVLLMKDRETNKSRGFAFVTFESPADAKDAARELNGKALDGKPIKVEQATKPSFSTPSRRGPPTSPRSRGPPRGLRGSRGGGSSRGQMPLKRGPPPRSGGPPPKRSAPSGPLRSSEMGGRAPLSRERDGYGAPPRRDPMPSRRDVYMSPRDDGYSGKDRYDGYSGRDYGSSRDSRDYGPPPRDYSYRDYGHSSSRDDYGSRGYSDRDGYGGRDSRDYSDHQSGGSYRDSYEGYGNSRSAPPARGPPPSYGGSSRYDDYSSTRDGYGGRDSYSSSRNDIYSSGRDRVGRQERGLPPSMDRGYPPPRDSYSSSSRGGPRGGGRGGSRSDRGGGRSRY
The following text describes a protein:
Function:
Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Is essential for chloroplast development and required for pigments and gibberellins biosynthesis.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MAMLQTNLGFITSPTFLCPKLKVKLNSYLWFSYRSQVQKLDFSKRVNRSYKRDALLLSIKCSSSTGFDNSNVVVKEKSVSVILLAGGQGKRMKMSMPKQYIPLLGQPIALYSFFTFSRMPEVKEIVVVCDPFFRDIFEEYEESIDVDLRFAIPGKERQDSVYSGLQEIDVNSELVCIHDSARPLVNTEDVEKVLKDGSAVGAAVLGVPAKATIKEVNSDSLVVKTLDRKTLWEMQTPQVIKPELLKKGFELVKSEGLEVTDDVSIVEYLKHPVYVSQGSYTNIKVTTPDDLLLAERILSEDS
The following text describes a protein:
Function:
Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.
Subcellular Localization:
Cytoplasmic vesicle. Golgi apparatus.
Sequence:
MTETQEMEALQRAQKERLDIVLKYDKGRDKGQKIDPWEDASFIIYRVTDRYGFCQNYVDVYSNGSENELPDFDEEEKKAKELELERTQKWLKMAKNWKRYYSSEKLTRRIYKGIPDKMRGTVWAMLLDLNKIKDEQPNVYERMKARARIHSPDIRQIDLDVNRTFRNHIMFRDRYGIKQQALFHILAAYSMYNTEVGYCQGMSQIAALLLMYLNEEEAFWALHILLTDTKHAMHGFFIPGFPKLIRYQDHHENILRKLLPKIRKNLDRLEIHTSLYSMKWFFQCFLDRVPFPLTLRLWDIFMLEGDKILTTMAYTLMKLHRRVMIKKDMELVVRYLQEQLVLDFGYRDDEVIDALQEGITELKRSKLLIPKPAKQNELAILPFGLMRQPSVSQQTGLRTAMPVSPPPVGNGTSRQSPSSIVSQPRSSETDKQKKTKPIPPAKPKNVTFKKEVTQSTSSSSQPPTPTSTIVSASNGTSQNTSPDKRKPDENYYSSVTSFESQYSARSSGTHPTRNSSGSPARSEPGSSRNNDLTPTGREFVEEFPYQGMPGEDVGYRRQNSNEKGTLRTGKASPLNERPQSLPPSSPTHTGDIGERRLSLYDNVDIYYNAHYEQSMEESLEAVGTPTPKAHAQDGMFYVTGIPNDPRVAGMSQGLNQAASTEIGNTSTNFKTYPEPVQAPGTSSQLSSPPPPTKPTSLGNLQSFEVQKTTHHYQKRTSWEGSQSQPGRSPSRSSGATASASARSPGATASASARPVRASPTRSSPTRNKPASPINGVQYFHSQVTYI
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MFAQRQMFFARLAANLRAPAVRQTVQRRFASTPANESGKNAFVREREAVKQHAAETTELWRKISLYGIPPALALAGYNAYTLYNEHWEHWSHLPPLEERTEYPYQNIRTRNYPWGDGDKTLFWNESVNYHNRDKVT
The following text describes a protein:
Function:
Converts carnitine to trimethylamine and malic semialdehyde. Can also use gamma-butyrobetaine, choline and betaine as substrates.
Sequence:
MSNLSPDFVLPENFCANPQEAWTIPARFYTDQNAFEHEKENVFAKSWICVAHSSELANANDYVTREIIGESIVLVRGRDKVLRAFYNVCPHRGHQLLSGEGKAKNVITCPYHAWAFKLDGNLAHARNCENVANFDSDKAQLVPVRLEEYAGFVFINMDPNATSVEDQLPGLGAKVLEACPEVHDLKLAARFTTRTPANWKNIVDNYLECYHCGPAHPGFSDSVQVDRYWHTMHGNWTLQYGFAKPSEQSFKFEEGTDAAFHGFWLWPCTMLNVTPIKGMMTVIYEFPVDSETTLQNYDIYFTNEELTDEQKSLIEWYRDVFRPEDLRLVESVQKGLKSRGYRGQGRIMADSSGSGISEHGIAHFHNLLAQVFKD
The following text describes a protein:
Function:
Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting; (Microbial infection) Acts as a receptor for enterovirus 71.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein.
Sequence:
MGRCCFYTAGTLSLLLLVTSVTLLVARVFQKAVDQSIEKKIVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEILRGETPRVEEVGPYTYRELRNKANIQFGDNGTTISAVSNKAYVFERDQSVGDPKIDLIRTLNIPVLTVIEWSQVHFLREIIEAMLKAYQQKLFVTHTVDELLWGYKDEILSLIHVFRPDISPYFGLFYEKNGTNDGDYVFLTGEDSYLNFTKIVEWNGKTSLDWWITDKCNMINGTDGDSFHPLITKDEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAEILANTSDNAGFCIPEGNCLGSGVLNVSICKNGAPIIMSFPHFYQADERFVSAIEGMHPNQEDHETFVDINPLTGIILKAAKRFQINIYVKKLDDFVETGDIRTMVFPVMYLNESVHIDKETASRLKSMINTTLIITNIPYIIMALGVFFGLVFTWLACKGQGSMDEGTADERAPLIRT
The following text describes a protein:
Function:
Catalyzes the transfer of galactose onto proteins or lipids.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MMSTRNVWIICGIIVTIAIYWPTRHARRYDYIDLKDVYKELQFTNKLSHLRNCNYKDVILNNSDVEISEPKNYFTPEHGGVHKPNHCNPLIKVAVIVPYRNRSLQLETFLNYMHNFLQKQYLFYRIFIVNQVDSLPFNRAKMLNYGAKVAIDMDFPCLILHDVDLLPLNSGNIYGCVSKPRHMSSSVDTFRFNLPYLTLFGGVVAISSQHFRKINGLSNHFYGWGGEDDDFYKRLTINDLSPCRFTPVLSRYTMLFHKKEKASPNRYDNMEKSAVLHKSDGLSTLPSNYSIKMEKLYTLILAS
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis.
Sequence:
MVGGGGGVGAGLLENANPLIYERSGERPVTAGEEDEQVPDSIDAREIFDLIRSINDPEHPLTLEELNVVEQVRVQVSDPESTVAVAFTPTIPHCSMATLIGLSIKVKLLRSLPQRFKMDVHITPGTHASEHAVNKQLADKERVAAALENTHLLEVVNQCLSARS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Cell membrane. Endomembrane system. Note=Associated with membranes.
Sequence:
MSSVTENGDVTAGKPNEEKTYKKTTSSAIKGAIQLGIGYTVGNLTSKPDRDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGINIRIVVMNNVLPRALKMNFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMHEGLYFDSETHSALMKTLQRDCRVLESFKIMDYSLLLGIHVLNSNVREKEGESSQNASDGKRPGGQKVLYSTAMESIQGPGKSGDSVVTETTNTMGGIPAKSHKGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSVHRPSFYADRFLKFMNTRVFKKVQALRSSPSKKRCNSITALKATSQEIVSAVSQEWKDEKHSIITEGQSYSSLDEEVLGSRRRPDLVPSTPSLFEAASLATTVSSSSLNVDERYQRDQTMLYSSSKELPSSSTFTLEDSAIYLTSEQSTLETENDNASVLDVYL
The following text describes a protein:
Function:
May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.
Sequence:
MTSDASHMLEAALEQMDGIIAGTKTAADFSDGTCEPGLSPPSSCLNSMPVLHLIEDLRLALEMLALPQEREALLSQIPGPTAAYIKEWFEDSLSQVNHHSAASNETYQERLARLEGDKESLILQVSVLTDQVEAQGEKIRDLEVCLEGHQVKLNAAEEMLQQELLSRTSLETQKLDLMTEVSELKLKLVGMEKEQKEQEEKQRKAESVLNVISELQEQMCRLQLDIHRQIQERLLLARDHPEEVVAGDHEAKPQPCSRDCAPWEGSPELLQELKHLKIKVEELENERNQYEWELKATKAEVAQLQEQVALKDAEIERLHSQLSRSSALHSDHAERDQEIHRLKMGMETLRVANEDKDRRIEELTGLLNQYLRVKEIVMATQGSSERTLSINEDEIEGSFRKWNTTSKSPEEVMKQEVSPRCSSPTPGPPPLPQKSLETRAQKKLSCSLEDLRCESGNKCINGNQTSPVGEPKDSSFLAEQKYPTLPGKLSGATPNGEAAKSPPTASLQPDSSGSSQPKLNRGWSISAPVLGDTEGGWEDIVMTNELSSTSSGTESSPQSPLTPDGKRSPKGIKKFWGKIRRTQSGNFNTDTPGMVEFRRGGLRATAGPRLSRTRDTKGQKCDANAPFAQWSTERVCTWLQDFGLAQYVIFARQWVASGHTLLTATPQDMEKELGIKHPLHRKKLVLAVKAINTKQEEKSALLDHVWVTRWLDDIGLPQYKDQFYESRVDGRMLQYLTVNDLLFLKVTSQLHHLSIKCAIHVLHVNKFNPNCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLRRHLTTKFNALIGPEAEQEKRDKMASPAYTPLTTTAKVRPRKLGFSHFGNMRKKKFDESTDYICPMEPGDAVSDSHRVYGVYRGLSPLDNHELDGLDQMAPSEGTVTQIGLLSQDIHRLTTLLSQDQLLNDPPGCP
The following text describes a protein:
Function:
May act as a polo kinase kinase by mediating phosphorylation of PLK1.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MAFANFRRILRLSTFEKRRSKEYEHVRRDLDPGEVWEVVGELGDGAFGKVYKAKNKETGALAAAKVIETKNEDELEDYMVEIEILATCDHPHIVKLLGAFYWEGKLWIMIEFCPGGAVDATMLELDRGLTEPQIQVICRQMLEALHYLHSKKIIHRDLKAGNVLLTQDGDIKLADFGVSAKNVKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLSCPSKWSLEFRDFLKTALDKNPETRPSAAQLLEHPFVSKVTSNRALRELVAEAKAEVLEEIEDSRDEAEDDDSSESASLPGKHKRDPSEVSQLSFDGDKPPDSSSLKTTNGPVATEKEMVNGQSDKVLDERISSDSDKLVNSHSTKTLASSGPDEGKATPGKPDIISLSGRRGSSAEGDKQPMPGSKERRSMVDRPESSHLENFPEEKLANGSLDSSAVFPGSRSKGDSDSGSTSASESMDLTISLSADLSLNRESGSISLKDSRMHNKTLKRTRKFVVDGVEVSVTTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQAQLNSKHQLQLDQMLRRFEQEMTAKKKFYDTELENLERQQKQQIEKMEQDHSLRRREEAKRIRLEQERDHVKFMEQLKQKKKEVKNEVEKLPRQQRKENMKVKMDDFAQRKQTMEQDFLAKQKEDLELAMKNITAQNKKEICDKERECLNKKQQLMRDREACIWDLEERQQQEKHQLIKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKIRQQQEKARLPKIQRSEGKTRMAMYKKSLHIHSSGSAAEQREKIKQFSQQEEKRQKAERLHQQQKHETQMKDMLAQCESNTNELQQLQNEKCHLLIEHETQKLKSLDENHNLHMKEWRDKLRPRKKALEDELNQKKREQEMFFKLSVEADEQTPASPVKHTKFIPFSSTESS
The following text describes a protein:
Function:
Tricorn degrades oligopeptides in a sequential manner.
Subcellular Localization:
Cytoplasm.
Sequence:
MANLLQNPDIYGDRILFTCCDELWEYSLSTGEKKRLTSHLGVVNNARYYDNGTKVVFRVMFGQSLDAADLFSIDLKSGELKRLTFITGKSVGRRKFTDVAGFSKDGSIIVSTDAFQPFSVPMLYKLGDDGSLDPLNLGPAVHYIEKNGRIYIGRDTYDLPHWKEYKGGTRGKIWSGTIEKGFKKIIDLENHISCPVIVKDRIYFITDIDGAGNIYSTNLDGNDLKKHTDFHEYYPRHLNTDGKTIVFSMGGDIYTFDPTNDNVKSLDIGPVFDTDLNQSYAPSKFLEDFSMSPGDMYSTVSRGKAFIFNENVNYSIPVKSDGRVRYSRFLSKNEISLVIGDKDGDSIGVFDAGTGEMKRKIGPLGNIFSVKSSADGKYLVVGNDNFQILLIDVSNGTVKEIDQSREGLIVDFAISKDSRFIAYSFPVKSSDLASYVQRHIKLFDMLNDKHYDVTTETANDFAPAFDADTNYLYYLSNRSLDPSTDRFTFNFGYLNITRPFVVPLKKGYVSPARNMPQDIEPEKGEYDLERLKYISEPLPVDQADYRSITPLKDGVLLFSVPIHGEFSSYYSGQPEKGIIVKFEFKDKKVKEIKKEVVDFKISTDGSKIMFSKQDGKLYTFRMEKPEEEKSLNIDAITIVSNVKEDFAEMYDEAWKLARDNYWDKEHALTISEKIYERYRKLVERCVTRWDLSYLITEIQGEYRTSHSYEMGGYFTDIDMPRAGRIACDFKYSNGEYVISDILYGDPSNENEKSPFLLSTLDADIGDAVIEIDGIPIGKGKSIYEALVGKGNRSVLVKIRKKDNSVRSGFVDVLQDDRYIRYRAWVEKNKKFVHERTNGRIGYIHIPDMGIMGLNEFYRQYVTEASRNGLIVDVRFNGGGFVSQLILEKLYMKRLGYDNPRRGTLEPYPMNSIEGPMIAITNEYAGSDGDIFSYSFKALHLGTLIGTRTWGGVVGISPRRKLIDGTVLSQPEYAFWFKGSGFSVENYGVDPDVVIEYPPEMYNVNVDPQLERAIEMVLADLEKYKIELPKK
The following text describes a protein:
Function:
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDTVQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWDKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPEVQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGVGSLGAQPLLQPSHYGQSGISMSHMDLRANPSW
The following text describes a protein:
Function:
May regulate voltage-dependent calcium channels.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MARAPGAPPDPPSLPLLALALALALALAPCPAQGVADAHFSILDEAQVLASQMRRLATEELGVVTMQRIFNSFVYTEKVSNGESEVQQLAKKIREKFNRYLDVVNRNKQVVEASYTAHLTSPLTAIQDCCTIPPSMMEFDGNFNTNVSRTISCDRLSTTVNSRAFNPGRDLNSVLADNLKSNPGIKWQYFSSEEGIFTVFPAHKFRCKGSYEHRSRPIYVSTVRPQSKHIVVIVDHGASVTETQLQIAKDAAHVILSSIDEHDKISVLTVADTVRTCSLDQCYKTYLSPATSETKRKMSTFVSSIKSSDSPTQHAVGFQKAFQLMRSTNNSTKFQPNTDMVIIYLSAGITSKESSEEDKKATLRAINEENSFLNNSVMILTYALMNDGVTGLKELAFLRDLAEQNSAKYGVPDRSSWPVIKGSMMVLNQLSNLETTVGRFYTNLPNRMIDEAVFSLPFSDEMGDGLIMTVSKPCYFGNLLLGIVGVDVNLAYILEDVTYYQDSLASYTFLIDDKGYTLMHPSLTRPYLLSEPPLHTDIIHYENIPKFELVRQNILSLPLGSQIITVPVNSSLSWHINKLRETGKAAYNVSYAWKMVQDTSFILCIVVIQPEVPVRQLKNLNTVPSSKLLYHRLDLLGQPSACLHFKQLATLESPTVMLSAGSFSSPYEHLSQPETKRMVEHYTAYLSDNTRLIANPGLKFSVRNEVMATSHVTDEWMTQMEMSSLNTYIVRRYIATPNGVLRIYPGSLMDKAFDPTRRQWYLHAVANPGLISLTGPYLDVGGAGYVVTISHTVHSSSSQLSIPGHTVAVMGIDFTLRYFYKVLMDLLPVCNQDGGNKIRGPGMESRPHLIIILAPFRNPSGGQTTSLNPIPTSSKKNFGGNSLHDRTVQTGFNKFKSSLVGDLTNLVHGSHCSKYRLTRIPGTNAFVGIVNETCDSLAFCACSMVDRLCLNCHRMEQNECECPCECPLEVNECTGNLTNAESRNPSCEVHQEPVTYTAIDPGLQDSLHQCVNTRCSQRMESGECFGVLDCEWCMVDSDGKTHLDKPYCASQKECFGGIVGAKSPYVDDMGAIGDEVITLNMIKSAPVGPVAGGIMGCIMVLVLAVYAYRHQIHRRSHQHMSPLAAQEMSVRMSNLENDRDERDDDSHEDRGIISNTRFIAAVIERHAHSPERRRRYWGRSGTESDHGETPETVKTPPGNNDPLSAGVDVGNHDEDLDLDTPPQTAALLSHKFHHYRLHPPSLHHSHHLQAAVTVHTVDAEC
The following text describes a protein:
Function:
Exhibits both acyltransferase and acetyltransferase activities (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Lipid droplet. Note=May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine; The di-lysine motif may confer endoplasmic reticulum localization.
Sequence:
MRFPNRKLHTAVNGGDSGVSTHFRNPFVHELRFTTLQKLKIAVMTVTLFPVRLLFAAFMMLLAWPFAFVATVGRSENAVEPLSWWRWLVDLALKAIMRAMWFSGGFHWVRVKGRPALPSEAPILTMAPHSSYFDAIPVTMTMASIVMKAESKDIPVWGTLIKFIRPVFVSRSDQDSRRKTVEEIKRRASSNGEWPQIMIFPEGTCTNRSCLIAFKPGAFIPGVPVQPVVLRYPNELDTISWTWQGPGAFKILWLTLCQLHNFVEIEYLPTYTPSEEEKKDPALFASNVRRIMAKALGLPIIDYSFEDCQLAMAKGPLRLPKHTCLLEFARLVRLLGLKTKVTDEVLQEEACSARQLCGRRLDMEGFAQYLHQPMTEAVQDIFSLFEEHGMMDVREYVIALSVVCRPFRYLDTVKLAFRMFEAQEDGAIVEDELTVILKTALGVGDLAVSELFRAIDSQDKGKITFDELCSFMEKCPDLVEQYHCLCESISQHSRESTSSSNGFCADFSPRNHSKKQD
The following text describes a protein:
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MPWLGRLELLLLAGCLGIKAGGKGGEGGTRHETRGCQGLIWRAGNGHGVPTPQDSPCRVRVCLLIPNHSTFPPPPSSTSPSPPASISTLSPPGSRPLVPGVQGLNQEEKLLNDLMRNYNPNLRPAEVDSDIINVTLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEDVWVLRIPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPNGCIYWLPPAIFRSSCPVTVTYFPFDWQNCSLVIFFFTFDSKDISFALPRPNPKRKGGKSVQLTVLAVTFNGSWGTEAWRKNQVNADPSPPSQPKPNELSFSLAIPSSIPPASIIQIHMITALAAGGQKCTVSTNVLLAQTVFLFLVAKKVPETSQAVPLISKYLSFLLVVTILIVVNAVIVLNVSLRSPHTHSMAQGVRKVFLHLLPQLLKMHMRPPAPRRLTRRLQNGSSGRPGLNGEGVAPWMPCTELVFQQRWERDGLSGHSQEFCASLKQAAPAIQACVDACKHIAWTRRHQRHYDNENEEWMLVGRVLDRVCFVAMTALFFCGTFGIFLMAHHNQVPALPFPGDPRPYGP
The following text describes a protein:
Function:
Member of the two-component regulatory system FleS/FleR that regulates the expression of multiple genes involved in flagellar synthesis, adhesion, swarming, motility and antibiotic resistance. May function as a transcriptional activator by direct binding to a cis-acting sequence upstream of the target genes (Probable).
Sequence:
MAAKVLLVEDDRALREALSDTLLLGGHEFVAVDSAEAALPVLAREAFSLVISDVNMPGMDGHQLLGLIRTRYPHLPVLLMTAYGAVDRAVEAMRQGAADYLVKPFEARALLDLVARHALGQLPGSEEDGPVALEPASRQLLELAARVARSDSTVLISGESGTGKEVLANYIHQQSPRAGKPFIAINCAAIPDNMLEATLFGHEKGSFTGAIAAQPGKFELADGGTILLDEISEMPLGLQAKLLRVLQEREVERVGARKPINLDIRVLATTNRDLAAEVAAGRFREDLYYRLSVFPLAWRPLRERPADILPLAERLLRKHSRKMNLGAVALGPEAAQCLVRHAWPGNVRELDNAIQRALILQQGGLIQPADLCLTAPIGMPLAAPVPVPMPAMPPATPPSVEIPSPAAGQDASGALGDDLRRREFQVIIDTLRTERGRRKEAAERLGISPRTLRYKLAQMRDAGMDVEAYLYAI
The following text describes a protein:
Function:
ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Coupled to the ATP-dependent transporter activity also has a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (By similarity). Involved in oligodendrocyte patterning and myelination.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MSVYSKLPSQLKKPLVKKAVVLLIALYGVKKLSPYFFGKLKGRTSKQVKGADPLTSNGEPLVEAARKRKRSPAVNREFFDRLIRLLKILFPRLFCKELGLLGFHSLALISRTFLSIYVANLDGQIVKTIVKKDPRAFVVELTKWLLIAIPATFVNSAIRYLEGQLTLAFRTRLVTHAYMLYFSDQTYYRVSNMDGRLANPDQSLTEDVVMFAASVAHLYSNLTKPILDVVVTCYTLIKTAESKGANTTWPSVIAGIVVALTAKVLRAFSPRFGKLVAEEARRKGDLRYMHSRIIANSEEIAFYGGHKIEMLQLQRSYNSLSRQINLILFKRLWYVMLEQFLMKYLWSASGLVMVAVPIITATGYSKYDSEDVKQAALDMKEEDLVSERTQAFTTARSLLNAAADAVERIMVSYKEVTELAGYTARVYEMFEVFEDVRDGVYRRSATEVKPEETGAPQNVTHGMRVEGPLQIRGQVIDVEQGIKCENLPIITPTGDVVVSSLNMQVDEGMHLLITGPNGCGKSSLFRILSGLWPVYSGVLYKPSPDHMFYIPQRPYMSVGTLRDQVIYPHSVQEMQEKGITDRQLEEILQTVSLRYILEREGGWDAVSDWKDVLSGGEKQRMGMARMFYHKPQYALLDECTSAVSIDVEGKIFEAAKDAGISLLSITHRPSLWKYHSHLLQFDGEGGWRFEKLDASTRISLQDEKIRLETQLSGIPKMQQRLTELCRILGEDSSLPTPGDEEEDEEEDEKQTERDVQSAGKEKDLME
The following text describes a protein:
Function:
Involved in the efflux of threonine and homoserine.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPGSTRKLPVWLPILVLLIAMSSIQSGASLAKSLFPLVGAPGVTALRLALGTLILIAFFKPWRLRFAKEQRLPLLFYGLSLGGMNYLFYLSIQTVPLGIAVALEFTGPLAVALFSSRRPVDFIWVVLAVLGLWFLLPLGQDMSHVDLTGAALALGAGACWAVYILTGQRAGAEHGPATVAVGSLIAAIIFVPIGAVQAGDALWHWSILPLGLAVAVLSTALPYSLEMIALTRLPTRTFGTLMSMEPALAAVSGMIFLGETLTGIQILALCAIIAASMGSTLTIRREPQIKQVDVK