lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDYDRIRPVRFLTGVLKWWRLWPRKESVSTPDWTNWQAYALHVPFTFLFVLLLWLEAIKSRDIQHTADVLLICLTTTALGGKVINIWKYAHVAQGILSEWSTWDLFELRSKQEVDMWRFEHRRFNRVFMFYCLCSAGVIPFIVIQPLFDIPNRLPFWMWTPFDWQQPVLFWYAFIYQATTIPIACACNVTMDAVNWYLMLHLSLCLRMLGQRLSKLQHDDKDLREKFLELIHLHQRLKQQALSIEIFISKSTFTQILVSSLIICFTIYSMQMSPVLQDLPGFAAMMQYLVAMIMQVMLPTIYGNAVIDSANMLTDSMYNSDWPDMNCRMRRLVLMFMVYLNRPVTLKAGGFFHIGLPLFTKTMNQAYSLLALLLNMNQ
The following text describes a protein:
Function:
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
Sequence:
MESKKEATHPKYIAKLEVSVNGAVETSDVIGAIFGQLEGLLGPELELKDLQRTGKIGRINIKLRREGEGSKGIVELYSGLDKVRTALLVAAMETIDKVGPYQANFKLIKIVDEREERRNDIARRAAEILKNWSIEKEDSFRRLIEFVERESAKSNFILYGEEQLPAGRGIEEASEIIVVEGRADVMNLLKYGFDNVIAMGGALERVPKSLEKLIEEKEAIAFVDGDRGGEMVLRTLLEQTDIDYVARAPEGKVVEELTAKEIRKALSSAVPADEVRRELGISPPKAKPFVEPEAHETRPAREINERIIRVPEVFRGFYERVMNTDKVLLLDEDFRILKETSVAELLNELNETRGVRYIIYDRIVTQRIVDKAYEIGVKAIVGNVAKDIVRKGAGLAIYTIQ
The following text describes a protein:
Function:
Involved in prephenate-dependent formation of 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-methoxyuridine (mo5U) biosynthesis.
Sequence:
MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADAVFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKALGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLARETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDYDLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVATVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHAKKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGNELDAARHPLQIVKFKLDKKIYPSNMMRKGK
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MPTNKPETTPGGENLLAALISCTTAAAFSATCTYPFDFIKTQQQLNNEKVMKKWNIPGNYPNSLAQLYKGGSALVLGSIVKNGTRIIAYNWSTQFMSIDSHNGNNNKTTAPRIVIAGVMSGFIETLWLIPFENVKITMIQNQTLANELKRCKNLGYDITGKVTHSPSTHHKSTKPIYLRQYVSPHAYLSSDVIDQYIKQKVRFGGVPIKDKALESLKFHYNKHPSLTLFGTVKEMYELKGLRAFTAGTFITFTRQIGISWVWLATYNATRQLIDPHNTNNEWFGHKHTMIQSVGLHFLSSMAVIMVTQPLDVIKTHLQSKNGNSLYRDSLSTAYKLFLQQGPWALFKGAFPRFLKVLISGGLTATVYEYVERLVDVAGHQKIFSQE
The following text describes a protein:
Function:
A component of the GATOR complex, which functions as a regulator of the amino acid-sensing branch of the mTORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the mTORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. GATOR2 activates the mTORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte development. Acts as an atypical component of the GATOR2 subcomplex, which can either promote or inhibit mTORC1 signaling, depending on tissues: inhibits mTORC1 activity by preventing the activity of GATOR2 in the ovary and the eye imaginal disk brain, while it promotes mTORC1 activity in the fat body.
Subcellular Localization:
Lysosome membrane.
Sequence:
MPPTETLRPGERGTAGGPGAGAPEQTYIVRQSNKYYEHRDSQATAMSVDYSGQWVLLAGRGHLALQRLGQDDGSLRRHERQSKYEVSVAEFAICPSRKEYCAIATSQHIDIVRWGTAEPHYEMSLRGHTRTVTDIDWHGKDPNLLVSCSIDTFSHIWDLREPRKPALSLNAVCMSGATQVGFNRVSGNLLAAAHDGDLRIWDIRKGSCPTHYITAHLNRVHGINWSHKRETCLATASQDGTVKYFDVCNPRRAEKIITTMSPVWRARYTPIGNGLVSIVVPHLGRGENSLLLWSNSKQTDPICSFVGHTDVILDFAWRPNRESSNEIELVTWSRDRTLRVWKIDDNMLKLCEPSAEEIESRFEPDLSELRVPTPPEFLHPRSILVAASLPISTGDGACNTLPMARSPSFGGGYYRREEPHIARSLTDQPTCSLHHEFSLLNTNMPHVEVDTLDAIKRYACFKICAGGHTVILQVTFTTSYPSPSAPPDFQLCQGTTLSSEVSGVLLKVLRCNALQRVKKSRTCLEQCLRALVAAMKKKVAAVGGADRSQLLLQSPRLEGALSSTLHDACIPYPRTSGVHFNAIGMLTTFAQPVNNKRLTLRQHTALTPRTFSSINGSGLLGNVMATAQREANASFYLQERMISGKPGKQRAIRQMNGSPVVHVYDTSSLLHISRRMAREFSLDKCNIAETCRKNGEICRQHGRLDLVPVWLLAELIATPQIPHETLNDLLFYKDPFKKSLLESLIMHYAISGDIQTAVLLACLFDKCPTGGGAIMEKTVRLPPQLNSQISPYHTVLPLDVKSSSSSNTWQQLKQLRSNSWSDSLDLEIKQIQSDAYACSLIRRTKMPLFDQFKRAYAEILFGWQLLSKRALILKHTQNTPPPVQGVEFVTECRKCAKPKRTPKCEPCKRPVLFCVLCRLPVKGAANACLACGHGGHIDHMMQWFEKHNVCATCGCKCLERTSELLALLS
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
MEPVKETMTTVKAEKPVTTTCSYWVLRKKRRCKMTANKGSEFCGAHASSAATTATCDEKAREDSFQERIPCPLDHKHTVFKRKLAKHLTICNARDQESSLPYIVKGVNSGDNLKETDEDLNKFNQIKLHELADEEFYSLIDKVKNLYDKHINSSIQELQLEHESLKEELSRKDYGQETLRQLTQTTSLLGILEHDHQLMDHTSYIEFGAGKGQLAYFLATVLQEQKLSHSQVVLIDRMSLRHKKDNKLANREVVQRIRADIADLKLSALPELKKTQRTVAFSKHLCGAATDLTLRCILGDGNASSDYVLIALCCHHRCSWRSYVGRKFLQEAGIGPREFVILTKMVSWAVCGTGLSRERRKAMESADFQLTETNTQRLTRQEREQIGQQCKRVLDYGRLEHLRSHGYQAELKFYVPRDVTLENVVLLARPTSPKLDQNKCC
The following text describes a protein:
Function:
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP); Thiazole kinase involved in thiamine salvage pathway.
Sequence:
MIDYSLYLVTSSEDLPAGATVESTVREAVRAGVKIVQLREKNLSTKLFLERAKALREICQPPVKLIINDRIDIAHASNADGVHLGQDDMPLLDAQNIFRVQEIIGISVNTVEEAVAAVRTGASYLGVGTCWPTGTKSIPEHKIIGPRGIKTIRDELDRLGLSVPLVAIGGINATNLIRTLYGCTSNHLYTDRYAESPIGVAVVSAIMKSPDPYQSTQTLKNMIQEFKGWLRAPAEPFSNPQVKIQLKLAVAMMKFHSKTSTPLIHHITNTVVQNDCANLTLAYGCSPIMSSNLNEMEDLVNLTTGSLVLNLGTFDDNQVRAMKLAGRQANLTGKPVIFDPVGVGASRERKKKANEILNAVQMSVIKGNQAEIASLARFNSNGVSSCGVDSSGEVEEPALLVKHLARQELCVVVMTGKTDWVSDGTHVFRLNNGVSELSGITGSGCMTGTSIGCFASLAQQEVVKDTHSGLLLNLKNIHHDFGETLLASILGISTINVVAEMVHQVEHEKLEHGPMNLKIKIMDRISLSRQIEPFWQAIHADIKLSSDFFHDDVAHHDEASSNGATRTE
The following text describes a protein:
Function:
Cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system. Acts by forming homophilic or heterophilic trans-dimers.
Subcellular Localization:
Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.
Sequence:
MARHHDAQNWPESTKMIGLLCFVASILTQHGILGQRVKVDPEVTSYPGQSVNLRCSFSDPTGVQLTMVTWIYESKDGLRNNIAVLHPSYEPNYPDSSLKGRVSFQSAQPEMTRPSIQIADLRMSDEGKYICEYATYPSGNEQGTTQLIMLAKPENSASTVSVEAGTEKTTVAKCESANGLPAAKISWVTTAKGNETTTKKAGTDNTVTVSSEYRMVPTPSDNGKDISCVVEHRTLEKPESFKMKLAVLFAPEVSISGYDNNWYMGRTSTVLMCEAKANPVPTSVLWKTMSGEMPDTVLISGNQLKVLKVDETVNTTFVCEVKNRLGTSKSQVTIVVREPSQKSSNAGVVAGIIIGVLLALLLLCAIVAVLVTRSRRQQQGYRAKGGSDLKTRMFGGGKKASKNGTGGGAGSGGTGGGNNNGSIFVYNDGSSHQGLPEKNNHHQPLNMGPRPGVVASTPTAQDILLRNELDEAEIRKFDDIEDEERYDHFSGAGPILQLRSTNDQENMMGGYLDDDMESQRDGSVISRTAVYV
The following text describes a protein:
Function:
Metalloproteinase.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Domain:
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence:
MRLIYVIAILLVSTCQAGFFSSLVSRFTGGGNSSPSSSSSSSSFSNSRKPSLSDEKARSYLQTFGYVPPSNSLQSRNGMAGDIQSAEQVFKSAIRKFQEFAGIAKTGFLDAATKAKMALSRCGVTDAPLALTSGSSQFKWSKTRLTYSIESWSSDLSKDDVRRAISEAYGLWSKVTPLEFSEVPAGSTSDIKIRFGVRNHNDPWPFDGEGGVLAHATMPESGMFHFDDDENWTYKDARKIHNNEATDLLAVAIHEGGHTLGLEHSRDENAIMAPFYQKTTDSSGNYVYPNLKSDDISAIQAIYGAGSGRSSSGSDFGGSSGGGSRTTARPTTTTRSWFGRFFGDDDDDVRSRTTTRRTTLWPTTQSPFSGDDWGSGSGSSGRGGSSSGSSGGGCPSHIDAYTPSSSFSYAFSGSQVYTISGTKVTKVQSIHDLFPSAPTPVNAALWNPISGSMLLFSSNRVYSYYFSNIRQIFQMDSGFPKTLPSDLGFSVSGALRWINGHQILMSSGDEFAVYDEFWNQVTLKNRISSYFPNLPRGVKGVESPAGSVITAFTSNQVFEYNSRTKSIGRQSGFSSYIAC
The following text describes a protein:
Function:
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors.
Subcellular Localization:
Cytoplasm, cytosol. Membrane.
Sequence:
MIEVVAELSRGPVFLAGEALECVVTVTNPLPPTATSASSEALAWASAQIHCQFHASESRVALPPPDSSQPDVQPESQTVLLPHRGERGQCILSTPPKILFCDLRLDPGESKSYSYSEVLPVEGPPSFRGQSVKYVYKLTIGCQRVNSPITLLRVPLRVLVLTGLQDVRFPQDEAVAPSSPFLEEDEGGKKDSWLTELAGERLMAATSCRSLHLYNISDGRGKVGTFGIFKSVYRLGEDVVGTLNLGEGTVACLQYSVSLQTEERVQPEYQRRRGAGGAPSVSHITHARHQESCLHTTRTSFSLPIPLSSTPGFCTAIVSLKWRLHFEFVTSREPGLVLLPPVEQPEPATWTGPEQVPVDTFSWDLPIKPEASHTFLSVQPASYCYSVRSHIRAI
The following text describes a protein:
Function:
Plays a role in apoptosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MCSTSVYDLEDIPLEDDDPNSIEFKILAFYARHHVFKSTPAVFSPKLSRTRSLSQKALGTWSTDSWTQISLPCRDSLSSEKHISLGKKKSSWRTLFRVTEKEEEPPSSPKEIHAQGPFPVERQGRNQHWSRSLSSVEQCLESEAVDSKVACIANRVAEIVYSWPPPDDSQSQGGGKFKESVPKILHFELQGPQLRPCDSKKDGEDQIINRIVELLKYSGDQLGREIKRDKALVSIFQEGLSYSVFRTITDLFLRDVDTRGESEIKAQGFKAALAIDAIAKLTAIDNHPMNRMLGFGTKYLREYFSPWVQQNGGWEKILGLSHEEVD
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically involved as part of the NUP82-NUP159-NSP1 subcomplex in nuclear mRNA and pre-ribosome export by acting as a linker tethering nucleoporins that are directly involved in nuclear transport to the NPC via its coiled-coil domain.
Miscellaneous:
MISCELLANEOUS: Present with 9470 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSQSSRLSALPIFQASLSASQSPRYIFSSQNGTRIVFIQDNIIRWYNVLTDSLYHSLNFSRHLVLDDTFHVISSTSGDLLCLFNDNEIFVMEVPWGYSNVEDVSIQDAFQIFHYSIDEEEVGPKSSIKKVLFHPKSYRDSCIVVLKEDDTITMFDILNSQEKPIVLNKPNNSFGLDARVNDITDLEFSKDGLTLYCLNTTEGGDIFAFYPFLPSVLLLNEKDLNLILNKSLVMYESLDSTTDVIVKRNVIKQLQFVSKLHENWNSRFGKVDIQKEYRLAKVQGPFTINPFPGELYDYTATNIATILIDNGQNEIVCVSFDDGSLILLFKDLEMSMSWDVDNYVYNNSLVLIERVKLQREIKSLITLPEQLGKLYVISDNIIQQVNFMSWASTLSKCINESDLNPLAGLKFESKLEDIATIERIPNLAYINWNDQSNLALMSNKTLTFQNISSDMKPQSTAAETSISTEKSDTVGDGFKMSFTQPINEILILNDNFQKACISPCERIIPSADRQIPLKNEASENQLEIFTDISKEFLQRIVKAQTLGVSIHNRIHEQQFELTRQLQSTCKIISKDDDLRRKFEAQNKKWDAQLSRQSELMERFSKLSKKLSQIAESNKFKEKKISHGEMKWFKEIRNQILQFNSFVHSQKSLQQDLSYLKSELTRIEAETIKVDKKSQNEWDELRKMLEIDSKIIKECNEELLQVSQEFTTKTQ
The following text describes a protein:
Function:
Cytosolic inhibitor of vacuolar proteinase B (yscB), probably regulating protease B activity during limited proteolysis. PBI2 is a component of the LMA1 complex, which is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi.
Sequence:
MKLLLLITLLLAALVSAAKYIPNKYILTFKDDSTPEATVDQVKKAIVSKGGKIGYEYSFIKGFAFSAPDKAIQYLKTTKEYANFPFILEQDQVVSLNDGESA
The following text describes a protein:
Function:
Important for the epidermal barrier integrity.
Subcellular Localization:
Secreted.
Sequence:
MGSSRAPRMGRVGGHGLMALLMAGFILPGTLAKSIGPFSDPCKDPTRITSPNDPCLIGKTGSNSISSHGGTSSISSQGGSSSISSHGGTSSISSQGGSSSSQGSSSGSLIFKPGTGYSQSSYSFGSGGSQTGSSGSQTGSSGSQTGSSGYQSGNSGYQSGSSGSQSGRWVSSSSQWVSSSSQSGSSGSSREGPGNGSALPTDDNSSRLTSGTVQSGGSYTSKSSSSNQRPCSSNVPDSPCSGGPVITHSGPYISGSHTVSGGQRPVVVVVEQHGSGGPGGFQGMPCSNGGPSGKPCPPITSVQKPYGGYEVVGGSADSYLVPGMTYSGGKIYPVGYFTKDNPIRGSPGSPSFAAGPPISEGKYFSSNPIIPSRSSNAYPSGIVFQPVGSGGVQPCGTGSIGSKGPCSGTRIQITSSGSSTSYHPCSGGASQGPCSSPGTNSISGGSSSVSTGKIVLQPCGSKSSSSGYPCLSVPSSTLNGGLNGSPQPVPSVVLKPCGPNSPGRVPCRSIRDILTQVKPLGPQLMDPQVFLPQGEPLDKS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNSTPANSTPLPPLQPFTPGSSAATPAPIALTRSKPRRRLSSNVVGVSDRRRLLQMLQNVEEVSPGPDSASEAGESPSIRSQDEAHLEHLSSARICMDEDKELLIHQALPAFENTLLRFVQALSKYDFRQDLAETLMETESQFCEAVDELVEHQQAAQTIAALERVSEGLDDKIRDMIRKLAECRRELRNYQPNNENQSTLSSADLLTYATRIANFTTAPPYFRERPEHSKLPWPIEDEMRKGLLALMEVGKDKTELGELADPEKFAHTAANGVAPNGAAPVANGVAQNHNNGYAMERRLSTGYGSDNDGDTNMNGRSGLAGLDIFDDDDDDDDDD
The following text describes a protein:
Function:
Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
Sequence:
MNREQELTHLFRREGLTPAVADLFRRIVYDWYASQRRELPWRETFDPYAILVSEIMLQQTQVERVREKYPTFLAEFPNLRALAAAPLERVLAAWQGLGYNRRAVNLKRCAEAVVASLGGELPADPNELVRLPGIGTYTSRAVAAFAFNTPLPFIETNIRSVYIHHFFADQSSIHDRDLMPLIEQTLDRDNPREWYYALMDYGSHLKRLHGNPSRRSSHHTRQTPFKGSNRQVRSRILRAVLENPGISRDALEKAVGASSEIVGKNLEQLAAEGFIVSRGPGYRIL
The following text describes a protein:
Function:
Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.
Subcellular Localization:
Nucleus.
Sequence:
MVALGGGVSCVQSTVLCVGREQRCPRAPRRPLPRRRGPHNGRRGGLKEGPHRKEAGARAQPRPQGHVVTSDAAHVRRAEEDEGGRGAMAASAASAAGQAGPGLATTDPDNHHHHHHHDDNDDDDEEEEEQLVMVELSGIIDSDFLTKCEKNCKILGIDTERPILQVDRYVFAGEYEDTLGTCVMFEENAEQVDSEGNRKTQLKYKCHTMKKLSMTRTLLTDKKEGEESIGGVEWLRIKDSDFSYRPKMICNFVQQKEDDEIAVQAQDKPLELGEEENVTNKNSGLNYELGKHDSGSLLESPSSETSVGTQDPKIIPM
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Sequence:
MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGRENKTAVVVGTITDDVRILEVPKLKVCALRVSSRARSRILKAGGKILTFDQLALESPKGRGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MFQRTLLRQAQAAKSIVSLRATSTTPSVIRRTSQLQSQLLSVRPVVRQPTYRFYSTENQAQNAEKAEAKENEAAEESPEESLRKELEAKEKEIVDLKDKYMRSVADFLNLQERTKRDMENARNFAIQRFAVDLLESIDNFDRALLAVPAEKLKAEVTESNKELMDLVSGLRMTQNILLNTLKKHGLERFDPSEPAEDGKPQKFDPNVHEATFMTKVEGKEDGDIIHTQTTGFKLNGRVLRAAKVGVVKNN
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. This isoform may play a role in regulating the transport, accumulation, and compartmentation of zinc in the hippocampus.
Domain:
Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence:
MDPNCSCATGDSCACASTCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGASDKCSCCA
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSTLSFNNISTEVLSPLNQFEIRDLLSIDALGNLHISITNIGFYLTIGAFFFLVINLLSINYNRLVSNSWSISQESLYATIHSIVTSQINPRNGQIYFPFIYTLFIFILINNLIGMVPYSFASTSHFVVTFALSFTIVLGATILGFQKHGLEFFSLLVPAGCPLALLPLLVLIEFISYLARNISLGLRLAANILSGHMLLHILAGFTYNIMTSGIIFFFLGLIPLAFIIAFSGLELGIAFIQAQVFVVLTSGYIKDALDLH
The following text describes a protein:
Function:
Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MAPSPKKEKEKEKEKEKEKAWARGKGIRRRPLLLRRAMLHSSACFFTGVLIGGFISTPPSDHVLPHYNKYWDWDWSWNWNWTSSAAADVVAAMINNHTNNYFLPRQQPAKQQPPMITSNLVVVMTCTELWEPERRAAGLSRTAHALRLVPPPLLWLVVEPSREALPTARLLRGAGVVYRHLTYKDNFTDGVLERHHQRNVALGHVEQHRLDGVLLFAGLDHVYDHRLFQHLREIRTFGVWSVATLVGGATAEMEGPVCARWAVTGTRSRSNKHPNMFAFRSTMLWDPTRWDRFPINQPDASQDSFKFMQRLVAEEYNKSRGMPDPDCSEIMVWRGDQLI
The following text describes a protein:
Function:
Mediates apoptosis and actin stress fiber dissolution.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS
The following text describes a protein:
Function:
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing histone methyltransferase activity. May belong to a complex that represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEVAVPEEPQKKIFRARKTMKMSDRQQLEVLHNTLATTNSSLSSSPPQTPLMNGTHTETEKDLNNKEGDLMAPATDSARCSPSPSFPVSRSPSPPNTQTTSPAMDLEDPLVATEEKKETSNKSSSSSPSASPAGLNCDPEVKEGFLCLSEEDETQADKDEKDSSEEKMNVDAETEDQKEEKDEKDTDTPENAEDNSAPVGLKRTLSEEKDEDDKEIEEERDGKRARLEGEELEAQLELKITANGGNRDKIEKMVQQLVEERLRVLQLTVFDRSLKELKDRVEKIDNVTKQQNALQHINTLQAKISRLAKKFGAANQASENAKRTQDAQAAAAAAQANNATNATTPQRTVKTTVDSKLSSSPTVSNSTAVPAQPKPLSTPATPTSSALATTAPILQIISTTTSSTPSSTSLPGQSQTGTLLLKTGPNPTVMTNAPATSGGQPVAMQQLLIQLPLAMANGQSGALVNAAGGVGLIPVSSLSTVSNINKAKTTTPATTFMLQKTAGNVSSATSSAPAVSLARAVYPGGTGTVSSPNTGISVTTARTPTQCAAVVGVSTAAASPGTTGPAATGSAAAAAGSPSASALASKTDNQASTPKTASQPGRPKGSVIDLTEDDDDVQVTGVQKATVSPVTTQRSSGPPPLVSSTPNTGTGVRSAQRSTVDSPSQSRPSSSSSTSLPPLPLAPSPPARLPPEANHTSPPQQPQLKLARVQSQNGIVLSWCVAETDRNCAAVDTYHLYAYHQDHQSSVSGASAQMLWKKIGEVKALPLPMACTLTQFVSGSTYYFAVRAKDVYGRFGPFCEPQCTDVITPASSAST
The following text describes a protein:
Function:
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
Subcellular Localization:
Cell junction. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MMATHWTGLPEGDGDKLKACGAACEVSKNKDGKEQGEPVSPSEDESFSWPGPKTVMLKRTSQGFGFTLRHFIVYPPESAIQFSYKDEENGNRGGKQRNRLEPMDTIFVKQVKEGGPAFEAGLCTGDRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVMPKDEDILQVAYSQDAYLKGNGAYSGNARDIPEPPPVCYPWLPATPSATAQPVEVSPPDSLLNKQQTSTPVLTQPGRAYRMEIQVPPSPTDVAKSNTAVCVCSESVRTVIVPSEKVVDLLANRNSPSGPAHRTEEVRYGVSDQASAKAAARTTPPPSAPTARLSHQTIGSRSLEPSGILLKSGNYSGHSEGISSSRSQAVDSPPVSVNHYSANSHQHIDWKNYKTYKEYIDNRRLHIGCRTIQERLDSLRAASQSAADYNQVVPARTALQVRRRSTSHDRVPQSIQIRQRSVSQERLEDSVLMKYCPRSASQGALTSPPVSFSNHRTRSWDYIEGQSEATATVNSESQTPDSNGERKQTYKWSGFTEQDDRRGIHERPRQQEMHKPFRGSNLTVAPVVNSDNRRLGGRGVGPVSQFKKIPPDLRPPHSNRNFPTTSGMSLPRGIAQDRSPLVKVRSNSLKALPPPVPKPSFSQHSLASTKDQRPVNHLHQHGLLSQQTRGRPESTFPHLELQTDVSPSLPGTSAKTSPQLSENLGTSDLDLHASPRNGDVDSQEADVQPSDVPDNKESVILREKPQPGRQTPQPLRHQSYILAVNDQETGSDPTCWLPNDARREVHIKRMEERKASCTSPPGDSLASIPFIDEPTSPSIDHEVAHIPASAVISASTSQVPSIATVPPSLTTSAPLIRRQLSHDQESVGPPSLDGQHTSKTERSKSYDEGLDDYREDAKLSFKHVSSLKGIKIADSQKSSEDSGSRKDSSSEVFSDAAKEGWLQFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDRREQTTPSEEEQPISVNACLIDISYSETKRRNVFRLTTSDCECLFQAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNSLLSSKTEQLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKGTWRRGIPSIVRKTFEKKPAATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLRTLKRLIHDLPEHHFETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGAEEPLTAVQEENTVDSQPVPNIDHLLTNIGRTGVLPGDVSDSATSDSTKSKGSWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQPSSSEDELDSVFFKKENMEPSHSEIKEESKRESETPGRKQRVVVAKDSNTKKDTGTTKEEKKMPSDEPSPPHSSKRNRSPTLSCRLAMLKESPRSLLTQKPHCEETGSDSGTLSSQASLARSSTKKSTSPETRHTEFLSNAGTITSDYSTTSSTTYLTSLDSSRLSPEVQSVAESKGDEADDERSELVSEGRPVETDSESEFPVFPSALTSGQFRGKLQEVARSSRRNSEGSEASCTEGSLTPSLDSRRQQFSSHRLIECDTLSRKKSARFKSDSGSPGDTRTEKETPALAKMFDVMKKGKSTGSLLTPSRSESEKQEATWKTKIADRLKLRPRAPADDMFGVGNQKPTAETAKRKNIKRRHTLGGHRDATEISVLSFWKAQEQSADKESELSAVNRLKPKCSAQDLSISDWLARERIRSSASDLSRSEGCEPQAESPSVLGTPTSTHTPPPSQQPEARAAASTSASTSQPPLSTPPQSPDQINGDSFQNTSQNASSAANAHPHKLSESPNTKTESPPCL
The following text describes a protein:
Function:
Has antibacterial activity against the Gram-positive bacterium L.monocytogenes.
Subcellular Localization:
Secreted.
Sequence:
AYPGNGVHCGKYSCTVDKQTAIGNIGNNAA