lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteasome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1. The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction. The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Present in the cytoplasm and nucleus; more abundant in the cytoplasm.
Sequence:
MGHLLSKEPRNRPSQKRPRCCSWCRRRRPLLRLPRRTPAKVPPQPAAPRSRDCFFRGPCMLCFIVHSPGAPAPAGPEEEPPLSPPPRDGAYAAASSSQHLARRYAALAAEDCAAAARRFLLSSAAAAAAAAASASSPASCCKELGLAAAAAWEQQGRSLFLASLGPVRFLGPPAAVQLFRGPTPSPAELPTPPEMVCKRKGAGVPACTPCKQPRCGGGGCGGGGGGGGGGGPAGGGASPPRPPDAGCCQAPEQPPQPLCPPPSSPTSEGAPTEAGGDAVRAGGTAPLSAQQQHECGDADCRESPENPCDCHREPPPETPDINQLPPSILLKIFSNLSLDERCLSASLVCKYWRDLCLDFQFWKQLDLSSRQQVTDELLEKIASRSQNIIEINISDCRSMSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNMSAASS
The following text describes a protein:
Function:
Probable regulatory subunit of serine/threonine-protein phosphatase PP4 which may play a role in meiosis and embryonic mitosis. Probably in association with catalytic subunit pph-4.1, regulates microtubule severing during oocyte meiosis II by dephosphorylating and likely activating mei-1, a component of the katanin microtubule severing complex.
Sequence:
MSELSDEEISLQALYDPSKKVIGDIEDGIFSTPELQPRIKTGIDNLQLVTKLVNQMRLFSSNEQIEDVPTNSLPYLLVPCFLGILHQNLMTEPGLKLDELRKSKIYMRNFLDRLRDLCLITTRLPWEDEDTEEQNLKEKPKLAVEEIRRLKLERHKKKQELKMAELRIQKQLEAVSIDEQNLRELYITQLLFWSERCYEELQAIDDELPLLKMMAERASHPHRHPAPPPATKTVPTLKPFIITRDAQQKQVFGLGYPGIPAMSVDEWYHQKFGHNPQNAPQSSAPAGAEAQESEEEVDDDEARAKAMRWDEYKDDHRRGWGNMHNKG
The following text describes a protein:
Function:
Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).
Sequence:
MALKFAANLNFLFTERATSIAERIRLAHQNGFRAVEIPYPEGETSDVVSAVKETGVVVSLVNLAFDKSDDQLRFGSTSVPGSEKLFRSQLDATIDFARQVNCGKIHLTAGLFKGGQESDYTKTYTANLKIAADSLRASKMIGVIEPINKYAVPGYYMNSYSKAAGILADVAADNIQLLADLYHLQHLHGNVSKTLEEYKALIGHFQIAQVPHRHEPDVSGELDYGFVFKALQEFGYDGWIGCEYKPKTTTVEGLGWVSKLGYTL
The following text describes a protein:
Function:
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. In vitro, can also use propionyl-CoA or butiryl-CoA as acyl donor.
Subcellular Localization:
Cytoplasm.
Sequence:
MAVSSGNSSVNSSKKLFSGKKGQSIGIVRSMNYKIPGTFGLESGKTLSGVRVEYEMYGKMNADKSNVILICHALTGDAHAAGFHEGDKKPGWWEIVIGPNKAFDTEKYCVICSNILGGCKGSTGPSSIDPETGKHYGISFPVITVKDMVNAQKKLIEHLGVKQLFAVAGGSMGGMQVLQWTVSYPEMVRKAIAIATTASTTPQQIAFGAIGRKAITDDPKWNGGDYYGKEIPSQGLALARMIGHITYLSDASMQNKFGRLQQDTDKSGIKGTTGTEGKNSSEISSEISSISSEISSELSYDFTPNFQVESYLNYKGDNFTKRFDANSYLYITKAVDYFDLAKNGSLIEGFSGVTAKYLVISISSDWLYPPYQSQEIVSALTANGVDARYEEIRSQHGHDAFLLEEGQLSYLLRSFLSHILVSDVMNRNFYTVSRDETIEHSSKLMVKECVSHLPVISEDGKLEGIVTSWDITKAVACKINELDEIITRDVKYVYEDEKIEHASSIMEKHSISALPVIDSEHRIIGIVTSESISALFGKYD
The following text describes a protein:
Function:
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
Subcellular Localization:
Chromosome, telomere. Nucleus.
Sequence:
MAGMGSLVLRPWIRELVLGSDALSSPQPGQLLEVLQEAEAEAPGPPRVPDTSDVAAALLVSDGTHSVRCLVTREALNASDWEEKEFGFRGAEGRLLLLQDCGVRVQVGEGGAAAEFYLQVDRFSLLPTEQPLERVIGCNQDPDVQKKLFDCLEEHLSESISPSPGLALSQLLDEVQEDQEHQGALVHLAESCLMLTGPCTAPPLTRWASTRCRATGEAVYTVPSSWLHISENDQRVLSSLGPGSRTQAPELPPPDPALQDLSLTIVSPSSPTSSGTPALPSHVSSEENGASISLLPALSLAASDLVQKGSSQAVPAICSAHGPLPPGSPHSNPVPSSPLLSCTPSLSPLGHVPSPHQAIVTKAQKPSLEFKELGLPLKNWHQSPRTKNATGALESSPVWDPPKRHRDGSAFQYEYEPPCTSLCAQVQAVRLPPQLVAWALHFLMEPQPESELTQV
The following text describes a protein:
Function:
Involved in protein export. Probably interacts with other proteins to allow the translocation of proteins across the chloroplast thylakoid membranes. Required for normal greening during embryogenesis. Central subunit of the protein translocation channel SecYE. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug (By similarity).
Miscellaneous:
MISCELLANEOUS: Cannot substitute for SCY2.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MITVSEVSSYSSSSSNFASLSRLNHKSSSRLRSSSLYKGSFFSVSTKTRRNTCKAKSWNLGLVINSRSSEASVFDPLGINPDETSGLSSIWESFVSLLSPSFESSSGNRRDKPSSGRGVAAAIEDSSIDFGDFFKGPLPGKFLKLLGFLALSRLGIYIPLGGVNREAFVGNLDQNSILSTLDTFSGGGIGRLGICSLGIVPFINAQIVFQLLAQVYPKLQDLQKKEGEAGRKKILQYTRYASVGFAIVQAIGQVFYLRPYVNDFSTEWVVSSVTLLTLGSVLTTYIGERISDLKLGNGTSLLIFTSIISYLPASFGRTTAEALQEGNYTGLGTIVVSFLLLVLGIVYVQEAERKIPLNYASRYTSKAGGLQKSAYLPFKVNSAGVMPIIFSTSSLALPATLARFTGISALKNVAFALTPGGSFYLPTNILLIAFFNYYYTFLQLDPDDVSEQLKRQGASIPLVRPGKSTALFIKTVLGRISVLGSAFLAVLAAGPAVVEQITHLTAFRGFAGTSVLILVGCATDTARKVQAEIISQKYKNIEFYELDKYDP
The following text describes a protein:
Function:
Involved in host defense at the body surface. Causes agglutination and suppresses the growth of the Gram-negative bacterium E.coli K12. Possesses calcium-independent hemagglutinating activity.
Miscellaneous:
MISCELLANEOUS: Binds lactose inhibiting its agglutination activity.
Subcellular Localization:
Secreted.
Sequence:
MVSFKLPAFLCVAVLSSMALVSHGAVLGLCEGACPEGWVEHKNRCYLHVAEKKTWLDAELNCLHHGGNLASEHSEDEHQFLKDLHKGSDDPFWIGLSAVHEGRSWLWSDGTSASAEGDFSMWNPGEPNDAGGKEDCVHDNYGGQKHWNDIKCDLLFPSICVLRMVE
The following text describes a protein:
Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Enhances the release of the neurotransmitter acetlycholine in cholinergic motor neurons, which in turn positively feeds back to depolarize body wall muscles and allows for the maintenance of normal body posture and locomotion.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQSSSLGNADDPRFRQTHLFQMLVKVINTSAENATKTAIATSSTSTPSFVDTYSTSSLLGEEGRMVMIVVIGAMFALVTSLGNLMVMVSFKIDKQLQTISNYFLFSLAVADIAIGVISIPMFTYYTAIQKWDLGYTMCQFWLCIDYLMSNASVLNLLLISFDRYFSVTRPLSYRPRRTTKKALTMIACTYIISLILWPPWIISWPYIEGKFTAEPGTCVVQFLQTNPYVTVGTAVAAFYLPVTIMCILYTRVYWETQKRQKEFGKLQATQTWASDVVDRPSTQSFRNSKMWKKVKKFSRRSMKRDVSSTSIIKSSGSMRKKNNQDGYVEDSVTPCTSSRNSKRKSWLRNCTGKSNSSSEDSSEAVAMNLDDTSLSSSHFALSGSRRRNISPPCTPMPTNFEDEEQTDAGASMRNGSARFRSRPSDTGKNNNSDTYTVLIELNDEGSRPSVRLSSCEPYLDEPISTRNRSKSDCNSEIDERRHSLLNKQSPFKNGRILKNFSSQERKSEKEQRKNERKQESKAAKTLSAILCAFIATWTPYNLIVCWEAFFPNTVPNVLWTFSYFLCYINSTINPLCYALCNARFRHTYMRILRCKFKAERPTMNQGYVRRN
The following text describes a protein:
Function:
Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR-cynTSX intergenic region.
Subcellular Localization:
Cytoplasm.
Sequence:
MLSRHINYFLAVAEHGSFTRAASALHVSQPALSQQIRQLEESLGVPLFDRSGRTIRLTDAGEVWRQYASRALQELGAGKRAIHDVADLTRGSLRIAVTPTFTSYFIGPLMADFYARYPSITLQLQEMSQEKIEDMLCRDELDVGIAFAPVHSPELEAIPLLTESLALVVAQHHPLAVHEQVALSRLHDEKLVLLSAEFATREQIDHYCEKAGLHPQVVIEANSISAVLELIRRTSLSTLLPAAIATQHDGLKAISLAPPLLERTAVLLRRKNSWQTAAAKAFLHMALDKCAVVGGNESR
The following text describes a protein:
Function:
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Sequence:
MNTYQALKVLDVDSNSSQEEIKAAFRKKALEHHPDKNKNKNEDLEFKKITEAYEYLKKNHHQRNDVYHNVQSQSKPKSNFKRKPWGAPDDETIPEQDWGKYTKEFEEGDPDFWKEYEKNFWEEYNARVRPDGRNGEYEKAKEPKKQPNLYVDVDKSLCIGCCSCEIIAPDVFQINKEKMMNPKSSVIDPKGAGVNKIMDAAMTCPTKAIIVEDIDTKERMYPY
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAAAAAGAAAAGASASGPGAAGGPVGPGAAAPPGAAEKERGGAAAAAAAAAAAGPAAPGGNSTRDKLLAGLEDLEVLARELIEILALSRNQKLLQPGEENQILELLILRDGEFQELMKLALEQGKIHHEMQLLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIDKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMSNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDLSLNMLPPNHSNDFMLEPPGHNKENEDDVEVMSTDSSSSSSDSD
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSHGQGIWSGTAGYWLVPYGSPVPEMNKVRREKVSKSQESLSQIQSLPAKGVSPRNESGMATNNNKEPWKEQDYCTAEGSSCLGMERKKRCFSNVPKKNLKTTWLPKFYGTVKPFICTKCGRRFRRIWNLLTHQRIHTGRRFPCSKCGKCFSHRKILIAHKWVHTGRKPFTCTECNKGFLWNRDLQKHLHDSRLQNQRNGNILICSQSEKRHREIKEFESRLWIHQEEKPIVCPTCAKSFEKKSDFDIHCLTHAGETPFVCAESGRSYKEKGKLTIHLRTHKGEQHCVCDECGKVFQDMFALRAHHRIHTDVKPYVCTECGRSYKEKGKLNIHLRTHKGEQRCVCDECGKGFRDMFALRAHHRIHTGVKPYVCTECGKSFNRKESLDEHFRRHIGMNKFACTECEKCYSNRRELNIHLRNHTGNLFPCTECQQVLSSKKSLKRHQMIHTGEKPFECTECGKCFREKRKLELHCRIHSGVKSFSCSECGLQFTWKTALQQHQLCHTGEKPFHCTECEKRFRSMSDLKVHWRHHTGEKPFVCKVCGRRFRDKNSLDSHLGSHTDERPFVCVECGKRYRQKSSLTNHLHTHIRDIKFVCNECGKSYNSERHLSAHRLTHVR
The following text describes a protein:
Function:
Ubiquitin E3 ligase required for class I crossover (CO) formation during meiosis.
Subcellular Localization:
Nucleus. Chromosome. Note=Dynamic localization on the meiotic chromosomes. Present as numerous foci on the chromosome axes and the synaptonemal complex central element until pachytene. From pachytene to diakinesis, restricted to a limited number of sites that correspond to class I crossovers.
Sequence:
MRCNACWRDLEGRAISTTCGHLLCTEDASKILSNDGACPICDQVLSKSLMKPVDINPNEEWINMAMAGISPQILMKSAYRSVMFYIAQRDLEMQYKMNRVVAQCRQKCEGMQAKFSEKMEQVHTAYQKMGKRCQMMEQEVENLTKDKQELQEKFSEKSRQKRKLDEMYDQLRSEYESVKRTAIQPANNFYPRHQEPDFFSNPAVNMMENRETIRKDRSFFSPATPGPKDEIWPARQNSSNSGPFDISTDSPAIPSDLGNRRAGRGHPVYGGGGTANPQSTLRNLILSPIKRSQLSRSRPQLFTL
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Sequence:
MSMPMQRPMAGGARAGQVQRSSAALRSVASQVPFTAHRANFSSKRVLRQDARVEAPSRVVVVRAEADLTGLTPGHPYPWEEDFDLLGDKVKEVTDQLLPDLRGCNIWLVGMMGSGKSTVGKMLANTLKYAFFDTDSVIELAHDKKPVSQIFAEEGQDYFRQCESQIIKELSPYRNLVISTGGGAVLKPQNWGYMHLGIVAWLNGDTELLARRVAKDGIEKRPLLAADAPEGADMQQVAKTKLDALLEDRRKYYENADVVVTLEGYGKDLEDGAPTAAVMYRLLTAINDKVQAKKREQAERMNFTIEGADQLKTMRTMDSPAGGLQLDGNQAP
The following text describes a protein:
Function:
Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
Subcellular Localization:
Endoplasmic reticulum lumen. Membrane; Single-pass type I membrane protein.
Sequence:
MRALARRSDRLPLLVVLSVMILETVTNQDLPVIKCVLIIHKNNGSAAGKSSSHVMVPESPEDLRCAPKHRSEGVVYEAVTVEVAQSASFTLQVQLTTPGDVSCLWVFKHSSLGCQPHFDLQNRRIVSMTILNVTETQAGEYLLHIQSEATNHTVLFTVNVRDTQLYVLRRPSFRKMENQDALLCVSEGVPEPTVEWVVCSSHRDSCREEGSAVVKKEEKVLHELFETDIRCCARNALGRECTKLFTIDLNQAPQSTLPQLFLKVGEPLWIRCKAIHVNHGFGLTWELGNKVLEEGSYFEMSSYSTNRSMIRILLAFVSSVGRNNTGYYTCSSSKHPSQTALVTILEKGFINATSSQEEYEIDPYEKFCFSVRFKAYPQIRCKWTFSQTSFPCEQSGLEDGYSISKFCDHKNNPGEYIFHGENDDAQFTKMFILNIRRKPQVLANASASQASCFSDGYPLPNWTWKKCSDKSPNCTEEIPEGVWNKKANRKVFGQWVSSSTLNMSEAGRGFLVKCCAYNSMGTSCETILLNSPGPFLFIQDNISFYATIGLCPPFIVVLTVLICHKYKKQFRYESQLQMIQVTGPLDNEYFYIDFRDYEYDLKWEFPRENLEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADRCEREALMAELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCHGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHSNSSMPGSREVQIYPPVDQVSGFNGNSIHSEDEIEYENQKRLEEEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSPSLFQCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEEIYFVMQSCWAFDSRKRPSFPNLTSFLGCQLAEAEAAMYQNMGGDVPLEHPAIYQNRRPASREAGSEPPSPQVQEKTHRERS
The following text describes a protein:
Function:
Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles.
Sequence:
MALPRKLISKIYDIKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNENNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFIADPPVTAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNGECLFVGSSSGISVIGWEPDRELDHIKSTWSSLADMKVVNNKLICGCHEIDTVSINTISLDRVIPFYQPPNSLPNFKHNSTNRKSFTRGNQKFRLSVGGAKPAQVQEEHEGDKSGLSSPNYSLEVVNEAVLESAETSPMSSLPPVHLASMAGSSADLAPHHVVYGGAIDSALRQGKYSRVPDNMASYGSSYGAIDTRLMSLNEPSSLHKPDIYNLYPLDKNEEADVQQLEFNLNDSNPPILNNYDNYEMAEDFPVNQNLNYITNNYKPVPATSTINASSKSIKKTTTTTLHKRTTNNMAGAKQTSTGIFGGSKLSQVSSVSSMELHKLDDNMVLKKSSSSNVVNKNKRPMGSAQSQFSKENNQQKNINVEIITKPPMRSRTTLDMRTSHQAKTQEKQIHQQPMNNRIIMDDHDFDMLSRSHEAVLQELSNRQSSLDLLRHATRSHDVLGALRQARSCGKSIFIDLLGAILEKPSSWNLDFCMFVLPEIYELLQSQHKFHFTRACDTLRIILSNFLPTIQENLDSWAANGLGVDVTREDRQRKCAECQRWLLQIKNLPESTHFGSTLSQLQNIIIF
The following text describes a protein:
Function:
Repressor of the lactose catabolism operon. Galactose-6-phosphate is the inducer.
Sequence:
MYAPERQQEILRLARDGGRVDVVSLAEEFQVTAETIRRDLKALDRAGLLRRVHGGAIPAGRLDFEPDLAERESTAADEKDRIARAALAELPAEGTLILDAGSTVARMAAAIPPDASLTVVTHSLPIAARLADHPGIQLHIVGGRVRHRTRAAVDAWALRAYGEIRADVAVVAANGFSVEHGLTTPDLAEAAVKRAALTAARRVVLLADSSKYAQEHFARFGALGDVDLLITDQGLTPEDAGDIERAGTEVVRA
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
Miscellaneous:
MISCELLANEOUS: Present with 259 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSKYGPLGITNFITPYDLCILILIHAHCSQDNGISVPTAVFLRLISPTRPSLEWNPLLKDNSNLRSSSIVPPPVLPILDNIIRILLDDKDGNKIALTLMGYLEAINGLDSINRLMMDLEKNCLVNNYRSMKMRTTSTRRQMTRASFLGTFLSTCIRKYQIGDFEMRETIWINLQNFKTVFKHTPLWLRFKDNVHIQKVKNCLLANDEISVEDQQMVEFFQHFNNGNDADSKTMNEENYGTLISIQHLQSIVNRQIVNWLDNTEFNLMGQEETSSTYEEQSGLVFDLLDTLSLNDATKFPLIFILKYLEAIKENSYQTALDSLHNYFDYKSTGNSQNYFHISLLSLATFHSSFNECDAAINSFEEATRIARENKDMETLNLIMIWIINFIEVHPEYANRFYITVEQIIKYLKNSSDVEDANIFSNAYKFETLLSMVKESKTAEVSSSLLKFMAITLQNVPSQNFDLFQSLVSYEVKFWKELGYESISDVYEKFLSKTSSSSLRNYDSSIINQDIKVAFKALEEDDFLKVKQYLLKSESLELDYDQKINLKYLRVKYLVKIGDYDLSMRLINQYVKECCEEVADSNWRFKFEIESINVLLLSDVGIRSLPKIIKLIDEYKEIGNPLRCVILLLKLCEVLIQVGKSMEAECLISCNLSTILEFPFVRKKTDELLESLSVEEDRDVQMT
The following text describes a protein:
Function:
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MASAFSLLTAGGAKFDKNRFKDDFQLFEAKKRKDRKGKSKQIDTLATGSALPSSLDFFGDHPHPQHKPEPEPESESESDFESDSGSSSTSIPAPPPQKITLTGAEPLPKSLHTNLPSLVNHESHSLTSAEGGPLLSALSRANIHSLWGVQCAVGGCLLEDRDTLCVAPTGSGKTLSYVLPTIVKLREPARKLKGTEEGKGVRALVVVPTHDLAVQIQGVIKAVTMGRHWRSMVLTKATEKAVWESAPGEAVKTGEDGDSEIKDGEDSGDEEEDEDDNGSTGSVDEFAPKVSGNPEGLGIDMLVATPERLHHLIDSRRISLARTKYVILDESDRLLSSDFLPQVEPILSACSNPAVQKCFLSATMPAGAESLAKKWLKDGGVRVVVGVKDSAVTTVDQSLLYTGSESGKLLALRNLISSGQLPYPSLIFVQSIDRAEELYKTLVLDGIKVDAVHGGKAKTKRDEAIKDFRVGAVWMLVVTEVLARGMDFRGVKVVINYDFPQTVPSYIHRIGRTGRAGRPGKAITFFNIEDGPYLRTIANVLRSSGCPVPEYMLDMKKPTKNEKKKLAKAPPKRKAVGGGGRDLNREAGKKKKQMVEASKKRKMLERKGKGGNEEKNDDEE
The following text describes a protein:
Function:
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
Sequence:
MDLMEKNLELIEVQKLEGHTDRVWNAAWNPVSPILASCSGDNSVRIWEQSSLSRSWSCKTVLEETHTRTVRSCSWSPSGKLLATASFDGTTAIWEDLGDEFECISTLEGHENEVKSVSWNASGSYLATCSRDKSVWIWEVLGGNEYDCASVLNGHTQDVKMVLWHPTLDVLFSCSYDNTIKVWWSEDDDGDYQCVQTLDESTNGHSSTVWAISFNAAGDKMVTCSDDLTLKIWGADISMMHSGEGYAPWTHLCTLSGYHDRTIFSTHWSSDDIIASGAGDDAIGLFVDSKQHDPVNGPSYNLLLKKEKAHEMDINSVQWSPSKESRLLASASDDGMVKIWQLETTP
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Binds to the flavoprotein subunit SdhA in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SdhB into the SDH catalytic dimer.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MNNLISKFNKIIYLNATKQTNKINCSFYSTTINNNNNNNNNNNNNNISNKKAEMSKENQQLLQDLEEEFDEDEFKPYVNPITKEIGGPKGPEPTRYNDWERNGRVSDF
The following text describes a protein:
Function:
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.
Sequence:
MVETGYTSPHLNQSVRSFTLSYGKLSPSISVPASLYSVATQLRDEFLMKYPAPSAEAIENDTDEVEFKQDIHLVARFIGLIAAKEEESHGHFTQLLNVFTLEFERTFLAGNEVHAVAARSGLEIPAQKDVIKCYYRSRFLSGRTIKNHGSALLNDPKVSLGAIFGGQGYEDYFEELVELYDVYAPFAADLVHRLAKHLLDLSQNEQAIKVFSKGLDVLAWLAGERPDRDYLVCAPVSLPLIGLTQLVQFYVTAKILGLDVGEFAAKFSASTGHSQGIVVAAVISASTDERSFFENAKSALTCLFWIGVRSQLAFPTTTLPPSVLSDSLECNEGAPSPMLTVRDLPMEVLNKHIKITNTHLPEDRKVCLSLINGPRSFVVSGPARSLISVPFHSSYLEGARADLENDLKDISFGKLQIPVYATDDARDLRAVAPEKLPMMLAVMITVNVVHWEEACNFPGVTHIIDFGPGGLSGVGSMTRMNKDGRGVRIIVSDSFESIDVGSKTEIFDRDVNSVQFAPNWLESFSPKVVKTTAGRCYVDTRMSRMLGVPPLWCAGMTPTTVSWEFCSAIAQAGYTFELAGGGYFDPNMMREAIHKLSENIPAGSGICVNVIYINPRTYAWQIPLIKAMVAEGYPIRGVTIAAGIPSLEVANELISDLGVQYICLKPGSTEAVNSVISIAKANPHSPSGFGGSDDTLPYLTGEWSDKFKLPPMPFDGVLFGSRLMVAKEARTSLGVKQAIVDAPGVEDKDWEKTYDGPAGGIVTVLSELGEPIHKLATRGVMFWKEMDDTIFSLPRPKRLPALLAKKSKIIKKLNEDFQKVYFPAHIVERVSAEKFKFEAVNDLAEMTYAEVLYRLIDLMYVTKDKRWIDITLRNMTGNYMRRVEERFTNVTGKTTIVEDFDVLSDPYTFADKFLTVYPEAKDQLINSQDAQHFFTMCANPLQKPVPFVPAIDETFEFFFKKDSLWQSEDLDAVVGEDVGRVAILQGPMAARHSTKVNEPVKEMLDNIHNAHIAALTEKLYGSEDKVPTVEYFGGEKPLTLKKSDLEGMTFEETAGEQAVYTAPLGSTSALPNLKSWFEILAGPEFSWRRAIFTTARIAKNWKLESNPVRRIFAPRYGQKLILKGSGDAAVVELYETVNGIYSLSAILKYNGENIICTLTDKRNALKEHVGLDFIFNYNRAAGYCPISEVLEGRNDRIKRFYWKVWFGNEPYPEEASITDTFTGPEVEITGSMIDDFCRVVGNQNEVYTKRGNAKRTAPMDFAIVVGWQAITKAIFPKTIDGDLLRLVHLSNAFRMLGETPLREGDKVKTSAVITAVINRENGKMVEVKGTLSANGTDVLEVVTRFLYRGNFTDFENTFEHTQETPMELTLSSPKDVAVLQSKAWFQVLDPERDLSGASLTFRLNSYSRFKNKTIRASVQTKGVVLMELPTKEVIQVASVDFQSVDCHGNPVMEFLKRQGKPIEQPVEFENGGYSLIRIMDDAYSSTFVTPPTNTPYAEVSGDYNPIHVSSVFAAFVQLPGVHGITHGMFNSAATRRFVETFAAQNVPDRVKQYEVKFVNMALPNSELVTKLSHVGMINGRKIIKIQVVNKETEEVVIVGSAEVEQPVTAYVFTGQGSQEQNMGMDLYSTSPVARAIWDSADNHFLSNFGFSILDIVRNNPKNLTIHFGAAKGQFIRKNYMDMIYEKANEDGTTSIVPVFPTITEESTSYTFTHPQGLLSATQFTQPALTLMEKAAFEDMRSRGLVQQNSVFAGHSLGEYSALSSMGDVMTIEDLVDLVFLRGLTMQNAVHRDAEGRSEYGMVAASPLRVSPTFNEAGLRFIVDHIAQQLKLLLEIVNFNVENQQYVVSGHLHSLSTMGNVLNFLKVQKIDFQKLVETLSMEQLKAELSEIVSKCHEKTLEELKKNNGIIELQRGYATIPLKIDVPFHSTFLRGGVRMFREYLMKRITPHQVNISKLRHKFIPNLTARPFDVTKEYFQEVYELTGSQRIKKIIQNWDTYASS