lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Sequence:
MGVILEGKPVAEKLEKEIKEKIQFYKSQGVIPTLCIVKVGKNAEAEAYAKSIEKFFSKIGINIERKNFNEEISLVDFKKIMKELEEDSAIHGVLILRPLPEELERGKAFQFLPTKKDVEGVTYENLGRLLVGEDSFHPCTPQAVLELLDFYQIPVEGKNVVVVGRSISVGKPLSLLLLNRNATITVCHSKTKNLVEFTKKAEILIVAIGKPYFVGKDMVGEGQVIIDVGTNVVDGKLVGDVNFEEVKDKVEYITPVPGGIGVITTRVLAMNLLKAVKKVEA
The following text describes a protein:
Function:
Confers resistance to the sphingolipid biosynthesis inhibitor drug myriocin (ISP-1). Inactivates ISP-1 by converting it into N-acetyl-myriocin. Cooperates with YPK1 in mediating resistance to myriocin.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MNLKLSAIESYFFHRSRLNLHSCFYVGIKLNELPKKSQLIAALKYTVIQHERLTCNVFYDELKKENFLQNILEPLKFCDLVEYRHDWDQLGETEINHIFQRYNFSYNENKPLWKILILPNQNQMLLLTDHVLMDGMSAIHVWETFMEGLQMQQPVEIDETIYSPSLNSSTEKIMSAPLYGDWPIPWNWHIVRQLVSRLHYWFPQTVVKNNRNLIQFANYSFPKDLLDDKPSDGTQKYKVKNTNHQWEFRLSPTHLNDILQECKANNTSLTSLLGALVCTSFEKIAAHEYTGSFLKIELPMNIRKPFERVLKLPSDDKLAVGNFIAVIEFNHKLHQNRGIWDIASQIQRAIRSSSEDKIIDKVNEVKLLEVISSQQYIEDKISLNNGPSSTFEVTNLGFQTFKDACNTSLPFYIVDATFNEPQGISSIFSLSVISTPGNGLHCCISYPNTLTKVLEPHWQYMKDYLNLY
The following text describes a protein:
Function:
Putative receptor whose ligand is not yet known.
Subcellular Localization:
Nucleus.
Sequence:
MYTQRMFDMWSSVTSKLEAHANNLGQSNVQSPAGQNNSSGSIKAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSYSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVVFPALYKELFSIDSQQDLT
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MRSSNSALAMLFAVALAMACTSALAQNSPQDFVSPHNAARAAVGVGPVSWDNTVAAYAQNYANQRAADCQLVHSGGPYGENIFWGSGRDYTAADAVNAWVSEKQDYDYNSNKCAPNKVCGHYTQVVWRSSTAIGCGRVRCNSGAIFIICNYKPPGNYVGQRPY
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MIDVDLQSLSSSDRIEYISTLIADSYNIAIAKKLEEFLDIQINEDVYLFQANSTLLKLYQFNPTHLNKDAIAKMLAKALMNFPCNDFLFLSYMIPSTIQKEEPLLKLFVLNNYLETCRFKEAWTHINAHSFFSEIPAFTNNIRNFISGVLSITYQNISLSMLGELLNLPSQEQLVEYIKTKQTTWKINDSTVSLQSDTSKQKKADTFTFDRK
The following text describes a protein:
Function:
In concert with the three peroxisome divisional factors, PEX11, PEX25 and PEX27, controls peroxisome morphology and abundance under conditions of peroxisome proliferation. Maintains mature peroxisomes in actively dividing cells.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MVSKKNTAEISAKDIWENIWSGVSSLLDFFAVLENLGVVNDKLYVSGLLRKVWLCYSCISVIKCVWKLIKLCKVKFKIDQRLDGEGNGLVKDKLINFKKKYNEHIRHITAALLQDLSYLMVLIYPGTRLFKRLSNIITLCRIIV
The following text describes a protein:
Function:
Highly specific potassium binding protein that is required for normal growth in the presence of high levels of external K(+). May act as a sensor of cytoplasmic K(+) concentration. Binds a single K(+) ion, which induces a large conformational change. Can also bind the larger alkali metal ions Rb(+) and Cs(+), and NH(4)(+). May be involved in the regulation of peptidoglycan cross-linking.
Subcellular Localization:
Cytoplasm.
Domain:
BON and LysM domains are both required for full K(+) binding. The major K(+) binding site is located in the BON domain and this initial complex is stabilized by interaction with the LysM domain.
Sequence:
MGLFNFVKDAGEKLWDAVTGQHDKDDQAKKVQEHLNKTGIPDADKVNIQIADGKATVTGDGLSQEAKEKILVAVGNISGIASVDDQVKTATPATASQFYTVKSGDTLSAISKQVYGNANLYNKIFEANKPMLKSPDKIYPGQVLRIPEE
The following text describes a protein:
Function:
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDMRLIVAGAGGRMGRALTRAIAESKGAVLAGALEAPGSEMLGKDAGVLAGLPANGIKLSADLWAMSKEADGILDFTVPAATIANVAIAAERGIVHVIGTTGLSGSDNAVIKSVTNRAVVVQSGNMSLGVNLLAAVVKRVAKALDQSFDIEIVETHHRMKIDAPSGTALMLGQAAAAGRGISLDEHADRGRDGITGARKPGNIGFASLRGGTAAGDHSVSFLGPFERLTLSHQAEDRMLFAHGALKAALWAHGKKPGHYSMADVLGLADI
The following text describes a protein:
Function:
May be involved in cell differentiation.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Secreted.
Sequence:
MKPFVGLLGLLLLLSFMKTCADDWTAISLQCADHWFHLRIRPTIFHNIFMEPDEVFLGIGCPVTTTWPNDTYEFIYRTYSCGIANKVLCDVTLLKTQLTYISKNASLQAEMSLSCVMHNQSPHFCEAESRGDFTGDPPGWTEDMRARRDEQTVPMVQPNLSTSSEDHHVSTEPWASETSRSEAAEVPSFMDQNFSVFHFSRM
The following text describes a protein:
Function:
RAB2B effector protein which promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis.
Subcellular Localization:
Golgi apparatus.
Sequence:
MKGGRDLKAARGGADRPLAPAYAPCRPGRLQRHLLSGEFDQLRDFPIFESNFVQVTRFGEVANKVTMGVAASSPALELPDLLLLAGPDKENGHLQLLGLFPLQFVQLFVHDESRQQLKVKFRTGRAFYLQLRSPPETRDCEFGRWVRLLYRLRFHSPTCAVPFTHEDTAPEEEEEEEEEEEEEEVKEGQLQPPEFQATEARLDPQVSELWGL
The following text describes a protein:
Function:
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Domain:
Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
Sequence:
MIGFSAFILRNYYAAIGWNEDNLYSSLTRTSSALLDFQLPQSLILQLANSPTPIFFTSYALDALPQLNGSISYITTSMPLDEIGSGRATAFKNVIERFRVFPPPKRPQPKDEVWLGGKRIEGRDYLLYSRLHLPSLHLSGLATTRLTPTLQAHLAFLSQPAHPTSTRPTPPQTPPSHTRQPSEPSTPAPSPTPGNVFISLQHDTGRYCGEYTYSVQDGMVGLRTLYNFGWHGDEESEVDKKERREREGKRIDEEEMMEGGLKGRFSAGGEVYFSAKQRSFGISTGLRFTTVPPTLPLPLNAPVPSPPTTLTLLYNPLIGFLSSAYSAQVSPTVALATRFGVNVYSYESDLSVGGEWWIGRRRGKRGLTTDAEPQLDAESRDPVVTGIEENRELTEKMAQRASLRQVTLRDEIGEDVHAEKELYSPIPVMTDVNAGELAQQISPRLQPQQDLDDERDGVLKARLSGNWQFALLYEARIRNCLVSAGVLADLTGRQHPIRSIGLEVQYFS
The following text describes a protein:
Function:
Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3'. Positively regulates the determination of retinal ganglion cell fate and formation of the optic nerve and retino-hypothalamic tract. Required for retinal circadian rhythm photoentrainment. Plays a role in brainstem auditory signaling and binaural processing. Regulates the differentiation of olfactory receptor neurons. During retinal neurogenesis, activates the transcription of several genes such as brn3d, coe3, cbfa2t2, glis2, elrC and xgadd45-gamma.
Subcellular Localization:
Cell projection, axon. Nucleus. Perikaryon.
Sequence:
MARLLHGAATAADWCELKELPSEPGLLARDYMLDSSDPRAWLSATSLQSRPEYGLHKMRELCKLKGLREDEEEEDDEEEEEERSEGLCRHRGPPGKGPGGVQKKRRLAANARERRRMHGLNHAFDQLRNVIPSLNNDKKLSKYETLQMAQIYINALSDLLEAPPDTSDPPCPPTYKLHSGGEARLAQSGNCRRFSGDFPGQSPLSFQFQEGAALSQKGMVSPTSSSSGENSKTSPRSHRSDGEFSPHSHYSDSDDA
The following text describes a protein:
Function:
Negative regulator of tomato mosaic virus (ToMV) multiplication, but has no effect on the multiplication of cucumber mosaic virus (CMV). Limits the spreading of the virus. Isoform BTR1S: binds preferentially and directly to the 5'terminal region of ToMV genomic RNA, and affects the efficiency of translation rather than mRNA stability.
Subcellular Localization:
Cytoplasm.
Sequence:
MESTESYAAGSPEELAKRSPEPHDSSEADSAEKPTHIRFLVSNAAAGSVIGKGGSTITEFQAKSGARIQLSRNQEFFPGTTDRIIMISGSIKEVVNGLELILDKLHSELHAEDGNEVEPRRRIRLVVPNSSCGGIIGKGGATIKSFIEESKAGIKISPLDNTFYGLSDRLVTLSGTFEEQMRAIDLILAKLTEDDHYSQNVHSPYSYAAGYNSVNYAPNGSGGKYQNHKEEASTTVTIGVADEHIGLVLGRGGRNIMEITQMTGARIKISDRGDFMSGTTDRKVSITGPQRAIQQAETMIKQKVDSATERTTD
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFASGHTTPRLGIDLAGGTSITLRAVPEAGQESAINKTNMDTAVEIMNRRVNGLGVSEAEVQTQGDRNIIVYIPKGTNSKEARQQVGTTAKLYFRPVLATELSGANATGTPSASETGGASDKATDKATDKATDKATDGDKATDGDKASGTPSDSASASATSQGRAASDALKADPSPSATSSDGASPSPSASASGDDATAKLQQQYAALDCTDKNARAKAGDGAKPDEQTVACGQNSQGQWQKYILGAAAVDGTEVDEAEAVYNTQTAAGWTVTMKFTDKGSKKFADITGKLAQNQSPQNQFAIVLDNEVVSDPYVSQALTGGNAEISGSFDQEEAQSLANMLSYGALPLTFKEDSVTTVTAALGGEQLKAGLIAGAIGLALVVLYLLFYYRGLSFIAVCSLLVSAGLTYVIMALLGPTIGFALNLPAVCGAIVAIGITADSFIVYFERVRDEIREGRTLRPAVERAWPRARRTILVSDFVSFLAAAVLFIVTVGKVQGFAFTLGLTTLLDVVVVFLFTKPLLTLMARRKFFASGHKWSGLDPKALGAKPPLRRTRRPSRPAAGPVDPKEA
The following text describes a protein:
Function:
Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein MoaD.
Sequence:
MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLSRAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYVTEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVIPGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFVTFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESLKRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLARVIGL
The following text describes a protein:
Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MAGARRKSLQSRQVGSLLIFLCVSVGGATTIRYSVAEEMESGSFVANVAKDLGLEVGKLAARRARLVSEGNKMHFRLHRKTGDLFVKEKLDRESLCGKADPCVLHFEIILVEPLQSFRAEVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLSANGYFHLHTRFRSHRPKYAELVLNKPLDREEQPEVNLTIMAVDGGSPPKSGTAHIRVVVLDVNDHVPQFSRPVYPAQVSENSPNGSLVATVTAMDLDEGTNKAITYSLAQNPEAILKTFQIDSQTGEVRLRGTLDFEDIETYDIDIQATDGGGLSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPEDSPPQTVVALFTIRDRDIRVGGKVTCFLREDLPFVIKPTFGNSYSLVTDRSLDREEVSGYNITLVAMDTGPPSLSAETMIEVLISDVNDNPPIFREDSYILTVRENNSPAVFIGQVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSDNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLNSQATVRVVVLDDNDNRPMILYPLQNGTLPYNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFCVQRQNGEIRTLRQISERDPMMQKLIILIQDHGQPALSTTVSLNILLVDGFSEPYLQFQDPTKHSRKVNPSTKYLVISLAILSFLFLLSVTVIFIIHVYQKIKYREKFTIQEHFYDDCNFSNNLVQGQGNGSLSQPCPYEMCSATGTGNSEFRFLKRFMPNFPFPHATGEIKMEAGSSLPLNSERNKSRRSEGHDQVSDDYM
The following text describes a protein:
Function:
Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MSDFPERDVKEFSFRQMSKLRVSDQPFPDDTSSVGRYNLIAVSNIYGITYVGCPTDLKVIQTAEMGKIHHSNTSGDINTIVDSLPMKRISIPCIHHLGLSCDELTLSVCYTREDGLALVMFDTRAFLSNDPKPPFCKTKLSTNKGVTVADVKWNPAHPNMLACLRSDGTLVILEVTDNNSMKMMANFDNTKGITAICWSPKGKQLVAGRQDGSFAQFTAVLQEKKSVPKPDIFGDSKAQVNDILWLSTYVFVVLYDVITDDASQPSLVVVSLPKKDEQRPTNFTNFEEICFGGGEDRDLKYFLHHVDEWGLVVCASSRSMEAAVIGKNLEDKNVWELWNLDDAARAELPLSTNHDETYPMGMAVDLTSTNHIPIGENQSLPPMPIFMLLSTDGLLCPFYMVNTAPPQPLTIIKPPTTLSAQGERQGPAQAASPAAAAKPVAPVAVQQPQPATAGKENTAPLPKPAAVPASTTFSFTQPQAPPAAAPTSSLFTAPTSTPKMGLQTTPSTTSGGLSLFGSAASSAAPKFGLPGASTTTSTGGLTIGGNSSAGFKFALPGGQQAGSSSAFSFSLPGSSQPGTTGGTSSQGFSFAAPGTTQPTAAPTGPGASAFSMAAPAGVSVKPAAVTSTTAVPAPGTTGATGLFSMPASTTVSSIAPAAPKTTGFGFGAPSAGQAFSFRPGTTTAQPGMPQSVSKPAVQPQQSGSVQPGSKPPSMVQASTLQPGNGPTQVVKPSAQQAKPVAVTQPAPSQPQPPPYRPPVTQPAAAVPARPAQPPAEEPGAVVEEDTFSASILDEISHFESEVANLREAAAKTDWKVGHPDELRKLKEETQQIGRFCDEIKDTTQSIHNDIHDLRTQTLETFAMLEEGKSRNDRNKEPYYHQLLRSQALDPASANKMKEVRQMYHYVDTTIRDVNNMLDDEWDKFKQQKSQKSGKLKSPALDVVYRAVSNHDKILHDQSQHIRKLSEQLKKMRLYNTTSSWTNRPVARSTTKTDTELSALADTLLHPRQDTTPERQKKSSSASPMSSKKQSQLRELLGKRQVTPVRSTTPASVSQSRLISPQRMYRASPRPASSTPRGREGDGLPTPPPPKIESPPLETPAGSTAQSRVKTVLQFSPPAEEQPLPLDRSQPVPMTTKPPEPAATKPVPSPSSGFAPVPFSQGATVLKGPSALTPKEAAAAAAMSRVGAANQQSAAFGSSNQKPAAFGLANQQPTGFGSISQAPATSSVGVAISQPASFGSSNQKPALFGSTNQQTAGFGSAIQQAAVSSTSNQQPLRFGATSQQSVLPDLTNQYPAGLGLANQLEAEDDLNDDGGSTEDVAPPVVNIKDVANLKPVSTGVTTAMVSDSVNRNALEAAQKILQSATATSKPATTTAAMSVPLSTSGFSFATPGQQPAFGQPANFGNLSTAPSTTAPQTSSTSMGSFVIGQGLSGSFSFKPAVTATLSSATQATQAQPKPVETKPTSSFSFSAPTGLSGLSFGQGTSSFGFGALSAASTTSTAAGATTDGSLLAKTLAEKPQDVKPPGSEQPSASGVEDITPPPTPEETPTSSTQVADVPAAPKPSFDFSKNQTEADTIQPGGFFLSPKSDTPPPEPPALSITSSQTAPTPTPATVVESKPTATATTTSLFGQSTTSSGFGFGLNTPSGFSALKPGTSSGFSFASPASSTAASGFSFTLPKTTAADKGASSTAASGFSFTLPKTTAADTTGGPSAGTASGFVFAQPKSTASDKTTLTAVTSASTTVASGYTTASPTRTTTAGTITTTAAGSTDSATTTAAPVQPSTTAPVDLTTPASAQPVAATTTTPAATTSEQPATTATTTTVSLFGPTTTNATTAGFGSAAQTTAASGGFLFGQQTTGGSTPAFGQPTTTATGTSGFGAASTTAGSSLFASTSGSSGSLFGQPAATTTTTSTSSFFGQPATAGSSGFGQSSSSGFGFGQTPTSGGLFGTATSSTANTGGLFGQTSTTPTGGLFGQSAFGSSTTTSSSGGGLFGSSSTTSTSTGLFGGGSTASTGGFFSGLGAKPSAEAASKNPFGGSTSFGTPSTSAASSLFGASPGTKAVGSTGFGTASSGGFGSPTSGGFSAGGSVAQQGFGAFSQPSQPQAPAASSGFGSPPSFGSTPAFGGSPGFGSTAAFSNPLGTSSQVFGSTPTGGGAFSQSSSAAPSFAANDAPTFGGIAAQSSGAPTFGGLAQGSPGFGGGGGGFGSPAGGFGTAAVFQQQPQQQQPQPGFGSSSGGFGQSAPSSQSSAFSSWR
The following text describes a protein:
Function:
Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression.
Subcellular Localization:
Nucleus.
Sequence:
MTCVEQDKLGQAFEDAFEVLRQHSTGDLQYSPDYRNYLALINHRPHVKGNSSCYGVLPTEEPVYNWRTVINSAADFYLEGNIHQSLQNITENQLVQPTVLQQKGGKGRKKLRLFEYLHESLYNPEMASCIQWVDKTKGIFQFVSKNKEKLAELWGKRKGNRKTMTYQKMARALRNYGRSGEITKIRRKLTYQFSEAILQRLSPSYFLGKEIFYSQCVQPDQEYLSLNNWNANYNYTYANYHELNHHDC
The following text describes a protein:
Function:
Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg) (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasmic granule. Note=Localized in granules from where it may be secreted or transported to other locations in the cell.
Sequence:
EPYLQVDFHTEMKEESGIAFHFQVHFGCYVVMNSREYGAWKKPVESKNMPFQDGQEFDLSISVLPDKY
The following text describes a protein:
Function:
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
Miscellaneous:
MISCELLANEOUS: Mechanistic analyses show the involvement of a unique ylide intermediate as the carboxyl acceptor in the conversion of SAM to Cx-SAM.
Sequence:
MSHRDTLFSAPIARLGDWTFDERVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPGTQVYDLGCSLGAATLSVRRNIHHDNCKIIAIDNSPAMIERCRRHIDAYKAPTPVDVIEGDIRDIAIENASMVVLNFTLQFLEPSERQALLDKIYQGLNPGGALVLSEKFSFEDAKVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKARLHNAGFEHSELWFQCFNFGSLVALKAEDAA
The following text describes a protein:
Function:
Phosphatase with phosphoinositide 3'-phosphatase activity that can use phosphatidylinositol-3-phosphate (PtdIns3P) and phosphatidylinositol-3,5-diphosphate (PtdIns3,5P(2)) as substrates and produces phosphatidylinositol-5-phosphate (PtdIns5P); participates in pathway(s) that transfer gene regulatory signals to the nucleus.
Subcellular Localization:
Cytoplasm. Note=Highly concentrated at the peripheral lobes of the epidermal cells.
Sequence:
MTALRPLSGRSRSLRCSSEKMEGTGSWDVLEWTKLDSASWSGSYSNLDCLLESERIIFEACGVILINTDEAGTLLLSNFRILFLSEGTRKLVPLGTIPFVAIEKFNKLAPKVQSNKYHNNENAPTRLLQVTGKDMRIVVYGFRPGTKQRHTVVDTLLRCNKPERVWDLYAFTCGPSQFGNTNPKERLLNEYFRLLGKSSQRASMNMIEDGSFTLSNDLWRITNLNSNYDLCQSYPFALMVPKSISDEELLQTSTFRARCRLPVISWCHPGSGAVIARSSQPLVGLMMNMRSNSDEKLVASFCTQLAGHKGARRKLYIVDARPRKNALANGAKGGGSESSSNYLQSEIVFLGIDNIHAMRESFSRLRDYLDMHGTTSSDGTSSFLRHGGWTWGGGNLSSMSASVSVLGDSGWLSHIQSILAGVAWIAARVAMESASVLVHCSDGWDRTTQLVSLACLLLDPYYRTFSGFQALVEKDWLSFGHPFSDRVGMPNVSESGNFELPIQSSSARSFPSSPVRQSPGSAAAQSSSSSYGLNNYSPIFLQWLDCISQLMRMYPSAFEFSPTFLVDFIDCLLSCRFGNFLCNSEKERQQCGISETCGCIWAYLADLRSSSGTSHVHCNPFYDPSRYDGPLLPPAAALAPTLWPQFHLRWACPVEPNVTETEDQCRAMTVKYSEMKKEKEEAERKVDELSSAMESLNEELLNERDISRAARESAKRATKERAVISRAVQSLGCKVKFTRNGDCTVEVEDGPQKCSHSIPQKQSEDNTTDVSESISSVTEQNVCEAVCPLRTREGTCRWPDAGCARIGNQFLGLKTNFEAFDNLCVYDSYFTAE
The following text describes a protein:
Function:
As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
Subcellular Localization:
Nucleus.
Sequence:
MSSLQLSKGALKQVFSKEGHDSVQIPMILQITNIKAFDVSPSDSKKFRILVNDGVYSTHGLIDESCSEYIKNNNCQRYAIVQVNAFSIFATSKHFFVIKNFEVLAPTSEKSPNNIIPIDTYFLEHPEENYLTVMKKSESRDRESPVPGVTPPLAQSTNSFKSEVGGGVAAQSKPAGTHRKVSPIETISPYQNNWTIKARVSYKGDLRTWSNSKGEGKVFGFNLLDESDEIKASAFNETAERAHKLLEEGKVYYISKARVAAARKKFNTLSHPYELTFDKDTEITECFDESDVPKLNFNFVKLDQVQNLEANAIIDVLGALKTVFPPFQITAKSTGKVFDRRNILVVDETGFGIELGLWNNTATDFNIEEGTVVAVKGCKVSDYDGRTLSLTQAGSIIPNPGTPESFKLKGWYDNIGIHESFKSLKIDNAGSGGDKISQRISINQALEEHSGSTEKPDYFSIKASVTFCKPENFAYPACPNLVQNADATRPAQVCNKKLVFQDNDGTWRCERCAKTYEEPTWRYVLSCSVTDSTGHMWVTLFNDQAEKLLGIDATELVKKKEQKSEVANQIMNNTLFKEFSLRVKAKQETYNDELKTRYSAAGINELDYASESQFLIKKLDQLLK
The following text describes a protein:
Function:
Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
Subcellular Localization:
Endoplasmic reticulum lumen. Membrane; Single-pass type I membrane protein.
Sequence:
MVLDIYCLLFFRKGPSIPMLSIVISAMAFGFIESQEPPLIKCMLIDNKISDSSIRTSSISMASDLMKDLGCSLRPESTGVVYEAAETVEVDIFAAITLQVMLSIPGNISCTWFFKNNSTVCHPDFDVQNRGIVSIVILKMTEIQAGEYLLSIQSEAMNYTVMFTVSVRSKLGKLGKPYFRKMENQNAVVCISESFPDPVIEWSFCSSQSKSCQRESQVVIRRKERVLDDLFGTDIWCCARNDLGEKCTKLYTLDLNQNPGSTLPQLFIKEGEPLLIRCKAIYENYEFRLAWKLENRTLKEENLFKMSTYSTNRTMIRILFAFVASVGRSDTGCYTCASSKHPNQSALVTVLEKGFINASNLSKDYEIDEHEEFCFSVQFKAYPQVVCTWTFSQKSVPCKQSLKNGFSVSEFCDHKNQPGEYTFHAENGDAQFTKTFTLYVKRKPQVKMDTSANQASCYSDGYLPQSWTWKKCTDKSPNCTEITEGIWNKRANREVFGQWTSSSTLNLSEQYQGLLVECCANNSLGSSCDSKLLSIPGFYYIIQDKVSFYTTIGFCLLFIAVLLILISHKYRKQYRYESQLQMVQVTGSSDNEYFYVNFREFEYDLKWEFPRENLEFGQVLGSGAFGKVMNATAYGISETGVSIQVAVKMLKEKSDSSEKDALMSELKMMTHIGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEVFKHDSFKNNSFPGISYKSDVYLYFTEEIEYENQKRLVEEEDFNVLTFEDLLCFSYQVAKGMEFLELKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMNDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSFGILLWEIFSLGVNPYPGIPVDNNFYKLIQSGFKMDQPFYATEEIYFIMQSCWSFDSKKRPSFPHLTSFLGCQLANAEVAMYQNIGDGISKPLSSYQNRSSCSSHVSPGQPPPQAQDKDS
The following text describes a protein:
Function:
Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation.
Sequence:
MDPRIAWIQPEQLGQAHQTWTQIWLTAQGLNQLHLNGNSNSNLDSNSAPVTPPPPPRNDGGQPQHNSAQDFIPLDSNRAPRTPLPNSAKRKRDNRASTYNCEPEGGTPWKTRHYAEGVIGLHEEILDFYKYMSPRMEEFAMRNEVVQRITNIIRSIWPRAKVEIFGSFETGLYLPTSDIDLVVFGSWEALPLFRLEKELRHSNIADPDSIKVLDKATVPIVKLTDRKTDVKVDISFNMPNGVKSAKLIKKFMQDYPTLKYLVLVLKQFLLQRDLNEVFTGGISSYSLILMTVSFLQLHPRYDATSPSANLGVLLIEFFELYGRNFNYLQTGIRIKDGGAYITKEEMQVNMDNGYRPSMLCIEDPLNQGNDIGRSSYGAMQVKAAFDYAYITLSRAVSSNKQYYASNNFSILGRIVKVTEEVVEYRQWIQQNWSQNIQPNPLLTQPTYASVARMPHVHNMQHQIQMQNQANHSNQLQAHAMTSHNAVGSTDSAGSEAMMVSDGEMSSHSASSSQASSPASSISASASSSPSNSDTDSSSESSSSSSLSPHGVTGIPDKAGAPSPKPGATPAPVTNSDAQTIPTATTRSATTVGTTTSKETSFPSSNVELSAAAAVTTSIVPSTTTRSVTPTAVTRTTDPTPAETPASAPTPAPSTVAAPVRQNTVSTSTANNSSNSSRPNTPNRGPRQQRVNSSSHGGEDMRRQHAGPSRMWHHSHNQGRTQYKQSSPHQNNKNFRNASNKKRRRPQQQPQQTRDNPSNSNSNSGHGTSR
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MKNANRLRASVSFARERVVSTAAASSAKGPVMQLVSKGARSDMELVFDRLHALDKSAQSDTISGKGLAQFLSEVGVEESSFECMVLLWKLGATQKGCITRSEWLLSVYAHGIESIVQMRQNVSAWVEDVRESGGSFLLMYNYLYDYIRGEEDRRMTLTTALGAWDVFFGKNDLYAKWKAWAVDHVKGGVSRDLWRQLGIFLTMDTTAAQRSGDHISALPWPSAIADFLDQDGVPAS
The following text describes a protein:
Function:
Plays a central role in vernalization by mediating the initial transcriptional repression of the homeotic gene FLC, a floral repressor, after a cold treatment. However, due to its transient expression, it cannot maintain repression of FLC, which is then maintained by Polycomb Group complexes containing VRN2 throughout development. Required to deacetylate histones on the FLC promoter. Together with VIL1, required during vernalization for the modifications of FLC and FLM chromatin that are associated with an epigenetically silenced state (e.g. chromatin modifications, histone deacetylation, and trimethylated H3 'Lys-4' H3K4me3 and 'Lys-27' H3K27me3) and with acquisition of competence to flower.
Subcellular Localization:
Nucleus. Nucleus speckle. Note=Probably DNA-associated; interacts directly with the FLC regulatory regions.
Sequence:
MQAASLSKIWRFDGNVGPENMDSSSFEDNECIETCKPNVLNVSERRELIHALSNQPEEASELLNSWSRNEIMKIICAEMGKERKYTGLNKPKLIENLLNLVSRPLGETSCSDRRNSRKKEKKMIGYIICCENLACRAALGCDDTFCRRCSCCICQKFDDNKDPSLWLTCDACGSSCHLECGLKQDRYGIGSDDLDGRFYCAYCGKDNDLLGCWRKQVKVAKETRRVDVLCYRLSLGQKLLRGTTKYRNLLELMDEAVKKLEGDVGPLSGWAMKMARGIVNRLSSGVHVQKLCSQAMEALDKVVSPSESVSGQGDKMTVRVEEIQARSVTVRVDSEEPSSSTQNKITGFRLFCRKSKDEECSSQGNCVVYLPETTSAIQGLEPDTEFCLRVVSFNEEGDLDESELRFTTLKDDGDEAGDQQSPLTNSSSGLCSNPSLPEDESNNVNKSCSKGNGDKDNTEHCSAGEVESELEEERLVKRKANKIDGRDLLVTPCKRDIYKGKQGGNKRFKSRTVSLNEKPEINNAANGVGDKDLGHIVKTIRCLEEEGHIDKSFRERFLTWYSLRATHREVRVVKIFVETFMEDLSSLGQQLVDTFSESILSKRSSTNGVVPAGICLKLWH