lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular Localization:
Nucleus.
Domain:
The N-terminal half of the protein contains two conserved domains I and II. Domain I includes a slightly degenerated ERF-associated amphiphilic repression (EAR) motif which seems to be involved in the activity of transcriptional repression. Domain II is required for the correct degradation of the protein through the SCF-mediated ubiquitin-proteasome pathway. Interactions between Aux/IAA proteins and auxin response factors (ARFs) occur through their C-terminal dimerization domains III and IV.
Sequence:
MDPNTPADFFKGSSKFHTYYSQTKKGGGVIDLGLSLRTIQHETYLPPARMIGLDGYGELIDWSQPSYNSITQLKSEDTGHQRLAQGYYNNEGESRGKYAYVKVNLDGLVVGRKVCLVDQGAYATLALQLNDMFGMQTVSGLRLFQTESEFSLVYRDREGIWRNVGDVPWKEFVESVDRMRIARRNDALLPF
The following text describes a protein:
Function:
MATalpha-specific protein that interferes with a-factor, the pheromone secreted by MATa cells. Contributes to mating efficiency. Acts to bind and sequester a-factor rather than to degrade it, and promotes the efficient mating of MATalpha cells by keeping the a-factor concentration at the plasma membrane within the narrow range needed for accurate pheromone gradient detection (Probable).
Subcellular Localization:
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.
Sequence:
MIFAPSFSLIKNILLVSFLISHSFAAKTLTSSSNDDTLARSAAADADMAFFMEFLNDFDTAFPQYTSYMMQNHLTLPQPVADYYYHMVDLASTADLQSDIAQSFPFTQFQTFITAFPWYTSLLNKASATTIYLPQHFITGETEATMTNSSYASQKNSVSNSVPFSTANAGQSMISMANEENSTTALISASNSSSTSRTSQSQNGAHAKSLYFPMALFGIFAVAL
The following text describes a protein:
Function:
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
Subcellular Localization:
Sarcoplasmic reticulum lumen.
Sequence:
MKPILSPLAILPVFSMIVINTAEAQDLEDAESRDSKLPHYLRDDGIKRVIDLDRNNFDRTLKQSKMLVLLFYLSSRSHPDSEKLWKSDRQMLEVVARILQPQGVTVAAVNVAEEYELAQKLGVKFSGAISVFHRGKRVEYYGHRSADVLVTFLHKMFDPPVTNIDNKKQRTLLEDAEGTKVVGYFDLENPQFKEFEEAAKNFQPLIPFYVVTDKKPIKEKNINKFVQSNKRQIITKIRLEDIHETWSSKVEGYLVTAFVKPKTIEGAQFFSLVRSLAKAYKSNEKLSFVWVDPDPFPMMRDYWQKSYRIDVSSPAVGVVDPKLNKSTWFKKKGKETKLRHLQEWMKDVLANKTEFLPASTDDEPASTQKQEL
The following text describes a protein:
Function:
Key RNA-binding protein involved in the formation of polar-growing hyphae which is essential for infection by the plant pathogen. During filamentation, assembles into particles that shuttle bidirectionally along microtubules to both poles. The RRM4 transport particles are part of the endosomal mRNP transport that regulates polarity of the infectious hyphae by transporting distinct mRNAs encoding, for example, the ubiquitin fusion protein UBI1, the small G protein RHO3, or the septin CDC3, from the nucleus to cell poles. Recognizes a broad spectrum of cargo mRNAs and precisely binds at stop codons, which constitute landmark sites of translation, suggesting an intimate connection of mRNA transport and translation. Also binds to the specific binding motif UAUG of cargo mRNAs via its third RRM. Plus-end-directed KIN3, a kinesin-3 type motor, mediates anterograde transport of RRM4-containing mRNPs whereas split dynein DYM1-DYN2 functions in retrograde movement of mRNPs.
Subcellular Localization:
Cytoplasm, cytoskeleton. Endosome. Note=Assembles into particles that shuttle along microtubules to both poles. Shuttles with RAB5A-positive endosomes along microtubules.
Domain:
The RRM1, RRM3 and PABC domains are important for RNA_binding and polar growth. RRM3 recognizes the specific binding motif UAUG of cargo mRNAs.
Sequence:
MSDSIYAPHNKHKLEAARAADAAADDAATVSALVEPTDSTAQASHAAEQTIDAHQQAGDVEPERCHPHLTRPLLYLSGVDATMTDKELAGLVFDQVLPVRLKIDRTVGEGQTASGTVEFQTLDKAEKAYATVRPPIQLRINQDASIREPHPSAKPRLVKQLPPTSDDAFVYDLFRPFGPLRRAQCLLTNPAGIHTGFKGMAVLEFYSEQDAQRAESEMHCSEVGGKSISVAIDTATRKVSAAAAEFRPSAAAFVPAGSMSPSAPSFDPYPAGSRSVSTGSAASIYATSGAAPTHDTRNGAQKGARVPLQYSSQASTYVDPCNLFIKNLDPNMESNDLFDTFKRFGHIVSARVMRDDNGKSREFGFVSFTTPDEAQQALQAMDNAKLGTKKIIVRLHEPKTMRQEKLAARYNAANADNSDMSSNSPPTEARKADKRQSRSYFKAGVPSDASGLVDEEQLRSLSTVVRNELLSGEFTRRIPKVSSVTEAQLDDVVGELLSLKLADAVEALNNPISLIQRISDAREQLAQKSASTLTAPSPAPLSAEHPAMLGIQAQRSVSSASSTGEGGASVKERERLLKAVISVTESGAPVEDITDMIASLPKKDRALALFNPEFLKQKVDEAKDILDITDESGEDLSPPRASSGSAPVPLSVQTPASAIFKDASNGQSSISPGAAEAYTLSTLAALPAAEIVRLANSQSSSGLPLPKADPATVKATDDFIDSLQGKAAHDQKQKLGDQLFKKIRTFGVKGAPKLTIHLLDSEDLRALAHLMNSYEDVLKEKVQHKVAAGLNK
The following text describes a protein:
Function:
Facilitates DNA repair, cell cycle progression, and cell proliferation through its interaction with CIAO2B.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Nucleus. Note=Mitotic spindle.
Sequence:
MAALGRPFSGLPLSGSADFLQPPPAFAGRAFPPGAAGHDLAPRPGVRGAPSSPGGRTARGRVSIHCRKKHKRLAEDDECPVRKKRLTEAELGAVTDEWALGAHQGREGHGVNTCPSSLSMPSMLDVVCEEMDQTTGEPQCEVARRRLQEIEDRIIDEDEEVESDRNVSHLPSLVLSDTMKTGLKREFDEVFTKRMIESMSRPSMELVLWKPLPELLPEKPKPSSSPKNYRRESQAKHAAPGTAFPQRTEGLLEPQCADAPLYRSLEAATSTEEEMEL
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. The K chain binds the dimeric form by interacting with the G and E chains (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSVYTIAGRQFQAHQLSLAVLGSVFVGPVIYSKLFKRNKPLSAKDVPPLNAKSKEEEEFILKYIEEHK
The following text describes a protein:
Function:
Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MHSYIRPYQHVALRLPSELTKIVRLVPNTVVYLGKYGSFPANTIIGRPFYLTFEIIDVSGENNDNCLRIVPPAELHAETLIADGEGEGDDVEVNEEGIPIRTNREIVDDASTQKMTAEEIEALKKVSTGAGREIIEKLLESHSALDQKTAFSLAKYTLRKRKKFLKRFTVLPVDVSLLTNYMLEGKEAMKTMELRDESIGLIGCWGNVHHGGQSSFEGAVASKPNGRYLVIDETGGLVVAAMAERMGILYPHDQEDEDQELAEGSEENGERQQTNAMAQALARRRHMAASGNSITVIHANKQPSLSLLRYFGYDQDNPDESHPLYKHMKTVSWMQLLDPHADTIYANEPEVIPDETLATFKSNRRSAYYKKRSRWERVRRVVDEARAGNFDGLIVATLMEPASVLKHTVPLLAGSAPVVVYSPTVEPLTELADLYSTPRRTAYITRKREIIAQHSLQQSLQGQSQDNEKKPQEPDFSELDKDFALDPSLLLAPTIETSRVRAWQVLPGRTHPLMSGRGGAEGYIFHAIRVFPSHQNIQAAGNPSRKKRKVAAQQESATPAESGSGVDVEMQS
The following text describes a protein:
Function:
Involved in rRNA-processing and ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPNASNPQRLLSYATSIAKCPTETVAYGSCVSSQAERIKQGDCSAEFKKLIDCVTKNLKKKLKRANRLLTFFKYNYKFVPPYRVLVDGTFCQAALTEKLNLAEQIPKYLTEETHLMTTKCVLDELEKIGPLLYGALVIAKQFEVAECPHKTPIAAADCLSHLARRAASGKTKYLIATQHDELTEKLRTIVGTPIMYIKFKTILLDNISEATKSGASKDEEEIKRLKQLKKEIMGPSDPLQKKKKKKKGGVNPLACKKKIMKASVETVRTGERTATGKRKRTKKKAPVESD
The following text describes a protein:
Function:
Acts as an E3 ubiquitin-protein ligase specific for ldb1, mediating ubiquitination and proteasome-dependent degradation of excess ldb1 in a RING-dependent manner. Does not degrade ldb1 bound to lhx1/lim1, nor lim1 itself and thus contributes to the establishment of proper ldb1-lhx1/lim1 stoichiometry and the formation of a ldb1-lhx1/lim1 complex. Interferes with Spemann organizer function and suppresses secondary axis formation induced by ldb1 and lhx1/lim1.
Subcellular Localization:
Nucleus.
Sequence:
MESADSTGKGSIEQSESQRQSQMDRLDREEAFYQFVNNLNEDDYRLMRDNNLLGTPGEITKEELLRRLQQIKEGPPQPSTEETRGDSVSTGGDPAEDSSNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRTSGNPSMPSLDQSAEMPGAEDMEVSSQGEAENEPEPIPIATRSAPAEVTVEEAPIQRGQRRARSRSPDQRRTRARTDRSRSPLHHAVDPPIRRAPHSSSQTVDTSNTEEAEGSSRTRHHVSSQVQNSSSSNETEGSSRTRQHIPARQQVLGTEGQSQSTVHLSNPETRSSSQTPQTDSSTNAETTGTGQRPPTIVLDLQVRRVRPGDYRQRDSIANRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYNDNDTDPNNPTAVSPTAAVPGEAQNNANAEVRAPSAEPTEPVAPVETDEGSNVSTTATRREGRNSRGAVTFEESGSLPFLSLAQFFLLNEDDDDQPRGLTKEQIDNLSTRNFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHIHCIDRWLSENSTCPICRRAVLVASNRESIV
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity); Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria (By similarity).
Subcellular Localization:
Cellular chromatophore membrane; Single-pass membrane protein.
Sequence:
MPQFDPSSFPSQIVWLVIALVAMYFVMSRLAIPRLAEVLEQRQRLINDDLKQAEALKAETEAAIAAYETALAEARARAHDEIRAVTEAAAKAAEARNAEVAKALNTRIKDGEARIVQARDEALTHVREVAGAVASDIVGKLAGLRVDDAALTAAVAAAIKE
The following text describes a protein:
Function:
Lectin that specifically binds to L-fucose and weakly reacts with mannose and N-acetyl-neuraminic acid. Has strongest preference for the alpha-1,6-fucosylated chain (core fucose) on glycoproteins among alpha-1,2-, alpha-1,3-, alpha-1,4-, and alpha-1,6-fucosylated chains. Binds to fucose residues of IgE in mice and human, causing antigen-independent IgE-mediated mast cell activation and anaphylactoid reactions in mice and is possibly implicated in allergic response to Aspergillus oryzae in humans. Induces secretion of pro-inflammatory cytokines IL6 and IL8 implicated in ocular diseases such as mycotic keratitis, probably through its interaction with host toll-like receptors TLR2 and TLR4, followed by up-regulation of pro-inflammatory cytokines.
Domain:
AOL adopts the six-bladed beta-propeller fold and contains 6 binding sites per monomer, each located between two adjacent blades. The 6 binding sites that are non-equivalent, and owing to minor differences in amino-acid composition they exhibit a marked difference in specific ligand recognition.
Sequence:
MSTPGAQEVLFRTGIAAVNSTNHLRVYFQDSHGSIRESLYESGWANGTAKNVIAKAKLGTPLAATSKELKNIRVYSLTEDNVLQEAAYDSGSGWYNGALAGAKFTVAPYSRIGSVFLAGTNALQLRIYAQKTDNTIQEYMWNGDGWKEGTNLGVALPGTGIGVTCWRYTDYDGPSIRVWFQTDNLKLVQRAYDPHTGWYKELTTIFDKAPPRCAIAATNFNPGKSSIYMRIYFVNSDNTIWQVCWDHGQGYHDKRTITPVIQGSEIAIISWEGPELRLYFQNGTYVSAISEWTWGKAHGSQLGRRALPPAE
The following text describes a protein:
Function:
Probable transcription factor involved in phosphate signaling in roots.
Subcellular Localization:
Nucleus.
Sequence:
MGSLGDELSLGSIFGRGVSMNVVAVEKVDEHVKKLEEEKRKLESCQLELPLSLQILNDAILYLKDKRCSEMETQPLLKDFISVNKPIQGERGIELLKREELMREKKFQQWKANDDHTSKIKSKLEIKRNEEKSPMLLIPKVETGLGLGLSSSSIRRKGIVASCGFTSNSMPQPPTPAVPQQPAFLKQQALRKQRRCWNPELHRRFVDALQQLGGPGVATPKQIREHMQEEGLTNDEVKSHLQKYRLHIRKPNSNAEKQSAVVLGFNLWNSSAQDEEETCEGGESLKRSNAQSDSPQGPLQLPSTTTTTGGDSSMEDVEDAKSESFQLERLRSP
The following text describes a protein:
Function:
Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.
Sequence:
MDPLKRVENELKKCVKCGACRAHCPAFAAWQREPAVARGKVAIAQHILKGDIELDEQTYAVMSKCLLCGSCVEKCPNDVPTDEIVVTARESLARRRGLTTFHKAVGQVIKNRRLMSFGALAAAILGPLFFRKVPQTSGLRLRFPLPFVGNRRHIPQIARKPFMDRHPEVIQGEPGKPRVVFYVGCMTNFVYTEVGEAALALFRHLGCTVIIPKGQGCCGLPGMSGGDLDTVRGLAEQNLAALERYEADYIMTACATCGGALHKFYPALIGKRHPELAARIRTIAAKTVDAAQLLQQLGLHPEETGAGERLKITYHDPCHLRTRNITRQPRELLKGSPGVELAEMEGADKCCGLGGTFNVYHYDTSLKINEGKSAAIEKTGADAVVTGCPGCMMQLSDGLKQHGNRTRVMHTLEVLARALRK
The following text describes a protein:
Function:
May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Sequence:
MLIDNVDALKSWLAKLLEPICDADPSALANYVVALVKKDKPEKELKAFCADQLDVFLQKETSGFVDKLFESLYTKSYLPSHEPTKVEAKPAGQEKEVTKEELSVKQNFQESVEEERDSRKKKHSSPQRSRADSSEQRTRDKRRDDGKWRDYDRYYDRSDLYRDKSSWRRGRSKSRSKSRGLSRSRSRSRGRSKDHDANRNVEHRERSKFKSERNDVEGTYNPVSASASNSTEQYSAAQSIPSAVTVIAPAHHLENTTESWSNYYNNHSNPSSFGRNPPPKRRCQDYDERGFCVLGDLCQFDHGNDPLVVDEVSLPSMIPFPPPPPGLPPPPGMLLPPMPGPARSLRIPVPQAHPQAPPPVVLPVPRPPLTQSSLINNREQPGTSAVPSLAPVGARLPPPLPQNLLYTVSEHTYEPDGYNPEAPSITSAGRSQYRQFFTRAQTQRPNLIGLTSGEMDTNPRAANIIIQTEPPIPITNNSSNVTRVVLEPDSRKRSPSSLECPPLKKPWLGKQANNNQNKPGFLKKNQYTNTKLEVRKIPPELNNITQLNEHFSKFGTIVNIQVAFQNDPEAALIQYLTNDEARKAISSTEAVLNNRFIRVHWHRESEQQPPLLQQQQQQSPSQSLHHQLHLQQQALTPAPAVTMHSNISKAMNKPLASGAYVLNKVPVKRRLGAAGGNQSDLSQAGAVVEDSQTFPTSASHSKMVYSSSNLKTAMKPGAGSKPHDVQEALKKKQEAMKLQQDMRKKKQEMLEKQIECQKMLISKLEKNKAMKPEERAEIMKTLKELAGKISQLKDELKTSSTASTPSKLKSKTEAQKELLDAELDFHKRLSSGEDTTELRKKLNQLQVEAARLGILPAGRGKTVPAQGRGRGRGRGGRGRGMLNHMVVDHRPKALTVGGFIEEEKDELLQHFSKFGDIEDLQEEDSPLSVVLTFKSRSEAENAANQGSKFKDRRLQISWYKPKVPSVSTEVEEEESKEEETETSDLFLHEDDDDEDEDEDESRSWRR
The following text describes a protein:
Function:
Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Primarily found in the equatorial segment of the acrosome. The tyrosine phosphorylated protein localizes to a smaller region within the equatorial segment (By similarity). Also expressed weakly in the principal segment (By similarity).
Sequence:
MRARGAGCPAGLLAVGWLILVGLQASQASNVTSSGGGVQEPAVAREGESESESESEEEAENEGEVPESETTAEADAEEEVQNRTIVKEVEFGMCTVTCGVGIREVILTNGCPGGESKCVVRVEECRGPVDCGWGKPISENLDSARLSCVHISPENRFKYVWKLLKPDQQPVILTNDSAVLEITREIRPLAFECDTLDNNEMVASVKFTVYTTNELQMRRSSRPDTDAVLVFVLTIGVIICIFVIFVLIFIIINWAAVKSFWGSKTSATEIQSELSSMRYKDSTSLDQSPTDIPVHEDDALSEWNE
The following text describes a protein:
Function:
Represses expression of mcbR.
Sequence:
MTNLTLDVNIIDFPSIPVAMLPHRCSPELLNYSVAKFIMWRKETGLSPVNQSQTFGVAWDDPATTAPEAFRFDICGSVSEPIPDNRYGVSNGELTGGRYAVARHVGELDDISHTVWGIIRHWLPASGEKMRKAPILFHYTNLAEGVTEQRLETDVYVPLA
The following text describes a protein:
Function:
Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.
Sequence:
MAVTCPICNQAVKGLDKINSHIDSGCQSFLETAADSATAQAEPQSSGQQSTQNGNLPPSSTQKKRSAADFFQTPAKRLAVSKIPIASTPLPVHGSAAASTAAQTPRTGTKRRFDEGPGLDSPSIDAARNRNGGDGSAETPQQNVNTGEGGVGTGGGEAQPSPPIQPLVKRTKPNNRSAPLAERMRPGSLDDVFGQDLVGPNGVLRALIETDRVPSMILWGGSGTGKTTIARCIAQRTGSRFIELNATSSGVAECKKYFGEAANELHLTGRRTIIFCDEIHRFTKAQQDIFLKPVEAGTITLIGATTENPSFKVVPALLSRCRTFTLQPLSRDDLQRILLRALKQEITDQHLPLSPLIDDELLSYLCAFADGDARTALNLLELALSLTTTTTTTTSSPDEPLTKESIKASLTKTLVYDRASDQHYDTISAFHKSIRGSDPDASLYYLARMLQSGEDPLFIARRLVVIASEDVGLADNSLLPLATATYTATQQIGMPEARIPLAHCTVALCLAPKSTRAYRGLNNAFSALREPGVAALPVPLHLRNAPTRLMKEMGYGAEYKYPPNYRNGRVKQSYLPGELVGRKFLEERDLGTEVDPDVEMGEGEDDGEVNGNGEGGVNGTTT
The following text describes a protein:
Function:
Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC.
Sequence:
MQRRKSLALSIPYQLDFFKQYKFLSQGKSQHILLESGRGGRYNIVGLNPVAVIRGKDETLHISESGKGTIKRGNPLDLMQEYMEQWKTDYNPEYPPFQGGAIGYFSYDCIRYIEKLPSLAEDDIDIPDIFFLLFDDVFVYDQKEQVLWVITHYVDKYEEAKERLNEWKSLWMTEAPEVTVPFESPEKKSEAVAFTEAGFMKAVECIQEYIGAGDVFQVNLSMRQERTLQTHPLEIYTSLREINPSPYMGYLELGDFQIVSGSPELLIKKQGTEVSTRPIAGTRSRGADEQEDEELARELIENEKERAEHVMLVDLERNDLGRVCKYGTVEVDEFMVIEKYSHVMHIVSNVRGEVEEDKDAFDLVKAVFPGGTITGAPKIRTMEIIEELEPVRRGIYTGSIGWIGYSGDTELNIVIRTLLAKDGKAHVQAGAGIVIDSNPENEYKESLKKAIALWRAKERSEETVR
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MKVKIVTPYGIVYDRESDFISFRTVEGSMGILPRRAPIVTQLSVCDVKIKSGDDEYHLKVAGGFLLCDGKDVIIITEEAGREEDISPDRFMEARERVERVRRFFQSSL
The following text describes a protein:
Function:
Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
Miscellaneous:
MISCELLANEOUS: Belongs to the high risk human alphapapillomavirus family. The cancer-causing human papillomavirus E6 protein has a unique carboxy terminal PDZ domain containing substrate.
Subcellular Localization:
Host cytoplasm. Host nucleus.
Sequence:
MARFEDPSKRPYKLPDLCTELNTSLPEIEISCVYCKTTLERTEVYEFAFKDLFVVYRDCIAYAACTKCLTFFSKIRELRYYSHSVYGDTLEKITNTGLYNLLIRCLQCQKPLNPADKYKHLKDKRRFHHISGYYRGQCNSCYNQSRQERLSRRRETQV
The following text describes a protein:
Function:
May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MFTLTKALEKALLQHFIYTKLDIAYAINKPFPFFEALRDNSFITERMYKESLEACQNLVPLSKVVHNILTSLEQTFDPSMLLILFSKVNLREYPSLGAICRSFRNVGNAYEGRNRPAPTLLGASTNPAEGCSFQTLLPQPRSQALPPSHLSSGLRIRDPGTTSLQITEILDEQPSPSHPAAPLPGYIREGKTTPVSSRDHQRKDKEDSQEMPHHPSGPEAVVKDILTSKTNNRDDSGAQPPGSPGTMHVVQDNSPAPNDPEVPQEAPCTPANKKARKRKSCIWSNSKRRRQKKKPPQHKMMGVASPGPGVQEKLKVVGQRTLNQDDSTRNVKVVTRTLRERTRCAQTSSSQEISKEASKPRARKRPQKRPHTAGRTIHVPEKSKDDAVDFLSPTLSVTCGEARGTLFKEKLKQGSSEKCIQNEAGAWLTVKEFLKKGGKATSKDWKKAIRCNKKTLRSLEQDGFLFCTSKSKPQKECD
The following text describes a protein:
Function:
Involved in riboflavin biosynthesis. Catalyzes both the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate and the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. RIBA2 and RIBA3 together are not able to complement the loss of function of RIBA1.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MSSINLSSSSPSTISLSRSRLSQSSTTLLHGLHRVTLPSNHPLSTFSIKTNTGKVKAAVISREDDLLSFTNGNTPLSNGSLIDDRTEEPLEADSVSLGTLAADSAPAPANGFVAEDDDFELDLPTPGFSSIPEAIEDIRQGKLVVVVDDEDRENEGDLVMAAQLATPEAMAFIVRHGTGIVCVSMKEDDLERLHLPLMVNQKENEEKLSTAFTVTVDAKHGTTTGVSARDRATTILSLASRDSKPEDFNRPGHIFPLKYREGGVLKRAGHTEASVDLTVLAGLDPVGVLCEIVDDDGSMARLPKLREFAAENNLKVVSIADLIRYRRKRDKLVERASAARIPTMWGPFTAYCYRSILDGIEHIAMVKGEIGDGQDILVRVHSECLTGDIFGSARCDCGNQLALSMQQIEATGRGVLVYLRGHEGRGIGLGHKLRAYNLQDAGRDTVEANEELGLPVDSREYGIGAQIIRDLGVRTMKLMTNNPAKYVGLKGYGLAIVGRVPLLSLITKENKRYLETKRTKMGHMYGLKFKGDVVEKIESESES
The following text describes a protein:
Function:
Represses the expression of yvaM and both rapG and rapH. Binds directly to the promoter regions of yvaM, rapG and rapH.
Sequence:
MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVPKPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLENEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD
The following text describes a protein:
Function:
Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAEEHKTERATPYKRRKVREEGNVAKSHEIASSLVVLLSLLLLLFLGTYIAKEVILIFLAVTGYVHADISELGSLYENFYENIVKVLTPLFFLALLVVILSHVAQFGFIFTLKPLSFKWERINPFEGIKRLISLTTLFETVKNTLKAFLLIGIAVFVLKGSLYFFLSSSTYPLAETLKSFIKTSAITLITLGVVALLIAFLDYAFKRWQYEKKIMMSRRELKEEYKQLEGHPEVKSRIKARMRELAKSRMMAEVPKATVVITNPTHIAIALKYNPEKDKAPVVVAKGKGTIAQKIVEIAENYSIPVVRKPELARALYPAVEVGKEISPKFYKAVAEIIAYVMFKKKKVYA
The following text describes a protein:
Function:
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Sequence:
MTTEKSLVAEAENSQHQQQKEEGEGVTNSGQQETQLEELSQEAAEGDNHCEQKLKTSNGDTPTHEDLTKNKERTSENRGLSRLFSSFLKRPKSQVSEEEGKDVESAKEKCEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEEHREDPDFETKEGGGLEECSKIEVKEESPESKAERELKASQKSIRRHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNGASKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVSGRLPCSFATLALLGSYTIQSELGDYDPELHGAEYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTLPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSDRSPRPTSAPAIAQSQDAEGTVPGAPVKKTVVSKAQKETVKDEEKKEEGPPDQAEPEPTEVWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQLPTGEGPPLVKTQTVTISDTANSVKSEIPTKDVPIVHTETKTITYEAAQTDDSNGDLDPGVLLTAQTITSETTSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEISEE
The following text describes a protein:
Function:
Required for the activity of the biotin synthase BioB.
Sequence:
MVEIVAGKQRAPVAAGVYNVYTGELADTATPTAARMGLEPPRFCAQCGRRMVVQVRPDGWWARCSRHGQVDSADLATQR
The following text describes a protein:
Function:
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MRGSARWQPPQPGHCHRHRCWCQSVLFGQDPFYRDTMVQQVPENISFPAEEEKILAFWTSFNCFQECLKQSKHRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKFLGIRGPEDVAKMGIAEYNRQCRGIVMRYSAEWKVTISRLGRWIDFENDYKTLYPQFMETVWWVFRQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLALCVNPDLQYVKLRDATGRVLILMEARLVALYKSESDYVILERFPGISLKGKRYKPLFEYFVKCKADGAFTVLVDSYVKGEEGTGVVHQAPYFGADDYRVCMDSNIIQKDSVPVCPVDASGCFTPEVPDFAGQYVKDADKNIIRTIKEQGRLLLAGTFSHNYPFCWRSDTPLIYKAVPSWFVRVEHMVDRLLENNDHCYWVPEFVREKRFGNWLKDARDWAISRNRYWGTPIPLWVSDDFEEVVCVGSVAELEDLTGEKLSDLHRESIDHLTIPSRLGKGPLRRVPEVFDCWFESGSMPYAQVHYPFENKRDFEEAFPADFIAEGIDQTRGWFYTLLVLSTALFGKPPFKNVIANGLILASDGQKMSKRKKNYPDPTAIISRYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNILRLHKEEQVEFLYNENAVKESSNITDRWILSFMQSLIGFFEVEMAAYRLYTVVPRLVKFVDTLTNWYVRMNRRRLKGENGTSDCIMALETLFSILFSLCKLMAPYTPFLTELIYQNLKTLIDPASVQEKDTLSIHYLMLPHVRKDLIDQKMENAVSRMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDAEALSDIKSLEKYILEELNVRQVTLSTDKKKYGIRLRAEPDHMVLGKRLKGAFKTVMAAIKELPSEQLERLQQTGSLVVEGHELHKEDVRLLYTFDQAQGSTSQYEAHSDAQVLVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDDITVYYRAPCQGDYLDTVIQSHTEFILATIKAPLKPYPVSPSDKVLIQEVTQLKGSDLEITLTRGAALPGPACAYVHLNVWANGREQGGVLLLENPKGHHRLDLAKLKGAVGCIFDLRAPELAVFHEKTEVLSKTDLLSLSGKTLCVTSGCPPAPAQSPGALCGFINLQLLGAKAQESPVGTLLLENPPGHQHLTYPGLLHEAAKVFGLRSRKLRLFLNESQTQEITEDVSMKSLNTKTVYVDVLPTTAEC