lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface. Seems to associate with DAP12 and is a receptor for CD99. May be involved in target cell recognition by natural killer cells and in activation of dendritic cells.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MALLISLPGGTPAMAQVLLLLSSGCLHAGNSERYNRKNGFGVNQPERCSGVQGGSIDIPFSFYFPWKLAKDPQMSIAWKWKDFHGEVIYNSSLPFIHEHFKGRLILNWTQGQTSGVLRILNLKESDQAQYFSRVNLQSTEGMKLWQSIPGTQLNVTQALNTTMRSPFIVTSEFTTAGLEHTSDQRNPSLMNLGAMVTMLLAKVLVIVLVYGWMIFLRWKQRPAH
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MESVLVPGEKPVRLLQWLVKVGDWLKYGTPVAIYRCIEDPSTGVKSKEMELKSRKVGKVKKFAMEVGQVAKPGGMILEMEACSHPVVMKDMCAECGVDLRMVKRRCEKQAHVSMIPSVPELKISKQQAEEIGNQDKSRLHKLNKLVLLVDLDQTLIHTTQNQAFAAMCSEDFFTFQLHKNEPTLYTKLRPYCREFLQEISKCYELQVVTFGSRLYAHKIAEFIDPKKKFFANRILSRDECINPMKKSGNLRHLFPCGDSMVCIIDDRDDVWSSAPNLVMVKKYSYFPGSGDINSPDKVEAKKQTGDTAKSETSKEVDKPEVETESPAVDNNSNNTRKRKSETDENDKSSKIMKNSHDGCDENEQKVKEKIIKQTNNGGNKKVECETKMECNNDADKPEVMIAKGNDVVLSSDSESDSSSDSSSSSSGSENSKDQIAETNSVEQSCQVSTSASSTESNGTSNTDNTTASSKENIKNKSEINTDSTVPSDVVSICKTTTIDNGSHSATAVCQKKENNSQVCSVYLKSLFPSVLADHDDYLKYLQSILTCIHYTYYDAYKKHLNGEFEHPPDLRGVVPFLRSKVLYGCCIVLTGIIPNNFKAAPHMHRAHIVARQLGAAINSTVDENTTHLIGAKKGTAKYQDALKMGKKKIHMVSIEWLWACSDRWERVSEKLFPMPSKSSRHSRSRSGTPPVHKYMFTTINNPAVNVTPAQTSEKRYDAVTGKLLKKVLDPRFEFMVSEAVTRKQKRKSPLYTSLKNPEKVIPVQFNQSSNEASTSTAVSATRTRKPSMAEVMGIGYTLSSNDIEDMDKEVEDLMNSDEDDGD
The following text describes a protein:
Function:
Transcription factor that acts as a negative regulator of fluconazole resistance in C.albicans. Also confers fluconazole resistance in S.cerevisiae by activation of the PDR5 gene.
Subcellular Localization:
Nucleus.
Sequence:
MSDDHSIHSHTQGLHHIKKKRVGKACDSCRIKKTKCDGKKPCNRCTLDNKICVFTEKKKTKEKKHPSGYVELLEARLDILTRSLEKLIELSRPHLQFIDDIITEEKSVDQEKSSPASSTPNSSSSDHHDDVEEQNSTGVVAPINKVVSYLIKEQGLLKNIPLEWEQGTEIAANFDPNRNLKSSSRLFAEHKGEAFIGSPVTSPQQMPTSNPFRRTSMFKEELESPSSDHYNESIFSQSVDEPYIKKEPNSAQFSKGTFSPQQQQLQQQQQMLNQFSLNTSRDISDIESDSSNKEDGLNSGSVSPPTSNYRSFSLFSDSNGEPILGKTSSLTSLTNKYENHSLSSPQTAINPVFNNSTTGPILTTLRRNSSSHSQKTLGSIQLQQKPRGSVHKPVRNHSRVSSFDKRMESTATAAATVAAVSGSVQLSQNTTPQNLPHLDNSQNNNYLRDNGMNNIGAGSVGGGLTFGAPSFTQPLSPSDDAIVYPTNQFTNRPATVSTFGGGLDVLVDNSLDPFFNI
The following text describes a protein:
Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
Subcellular Localization:
Nucleus.
Sequence:
MPTLSENVLFGMGNPLLDICAVVDKDFLDKYGLKPNDQILAEEKHKELFEELVKKFKVEYHAGGSTQNSVKVAQWMIQSPYKAATFFGCIGKDKFGEILKKKTEEAHVDAHYYEQTEEPTGTCAACITSDNRSLVANLAAANCYKKEKHLDVEKNWKLVERANVYYIAAKHAQLFHPLLIGLVLQTLDHISCSPLDTFQLVNISLQLRCPELDTVFQGFFLTVSPESILKVASQASANNKIFTLNLSAPFISQFYKEPMMKVMPYVDILFGNEMEAATFAREQGFETEDIKEIAKKTQALPKVNLKRQRVVVFTQGKDDTIMATENEVKSFPVLISDQSEIVDTNGAGDAFVGGFLSQLVYDRPLTECIRAGHYAASVIIKRSGCTFPEKPDFH
The following text describes a protein:
Function:
Calcium-permeable stretch-activated channel component. Probably involved in mechanosensing and in mechano-stimulated calcium uptake mechanism.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MANSWDQLGEIASVAQLTGIDALKLIGMIVNAANTARMHKKNCRQFAHHLKLIRNLLEQIKNSEMNQRSEILEPLQGLDDALRRSYILVKSCQEKSYLYLLAMGWNIVNQFEKAQNEIDLFLKIVPLINMADNARIRERLEAIERDQREYTLDEEDRKVQDVILKQESTREAATSVLKKTLSRSYPNMGFCEALKTEEEKLQLELQRSRARYDADQCEVIQRLIDVTQTAATVEPNLEKVLTKKEELTSSKKRDDLYDTDSSSIRADSRSTSYVSSGHELLSGRSLQHRGNWHADLLDCCSEPCLCLKTLFFPCGTLAKISTVATSRQISSTEVCKNLIVYSLILSCCCYTCCIRKKLRKTLNITGGCIDDFLSHLMCCCCALVQELREVEIHRASYGTEKSNKEMSPPTPQFMEE
The following text describes a protein:
Function:
Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Also binds other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGFNRSVSNIGSVSNDTTEDTDALFHISVLVPVTVLCMSLFLLGITGNLITIIMFKRYRDMRSTVNMYLSSMAISDILIFLGLPSDLYRIWKYKPYIFGDFVCKFLVYLSESCTYCTILHITTVSIERYIAICFPLKAKIIITKRRVKIVIILLWIFALLTAGPILFLFGVENPPGFQAEETKECKYTEQSAQNGLLHVMAWVSTIYFFLPMFFLTFLYGLICRKLWRTRHGARGPPAANRGKYHKATIKMLAVVVVSFMLCWLPFHTGRILFALAGVGEHVFFEVTQYFNLLSMVLFYLSASINPMLYNIMSKKYRSAMRRMMYPKRGQQSGRTRSDQFSLEGTELGHINFPDRGNPQLFKKPLKYNGESIMLCQM
The following text describes a protein:
Function:
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MKFLKLPQSYHNGGIHSIDVNQDNTILVSGGTDNKIGVWNLKKLIELSKLVSTHNSPEVRLKLKSLEPKQYITCHKSLINVVRFFKGDNKRFISSDVNGNVFFHTLHEQPETKQLFPFKSIETSEVNPVVDLTISADNRLIAWSTNNGKVYLYDVVKDTFQELTSICHEKPIIQRSIAFDPSNNYLITVGDDTQINVFQYSYEKDDTSTTTYKFRLIYKISKLFSQNPLNVRYKRISWSPDGNLVSIPTASKNQTMLISLISRSEKWTNIESLVGHDFACDVVKFNPKIFSSKENDTSKVHSVIASGGSDRTMAIWNTSKSTPITVLQDAVQGEILDITWTTDGTSLLFCTSQGKLCIGNFEPNELGYTFSQETMERFVQLQNNLIEPMNFRYPHEQTVGNRKQLPPIEFLSQKNAISTTTSSSNTVENDKKNAEDNVGVSNQSKSTTTTTTTTIKGGVITPEVIPPPKLQSLDDDIDGDGDDEEHKSGGMLDSVMNDRTQSSPRKLNKPKPIAPVVSDSTTQSLSFNKQKVTTKNGKRRIQPMLISSGNSAPSDLPRSNSVIKPVVNTTKSTMEFEKPSYSVSEEFYKQNKRPRTEETTGSNNNKKLKREMEPVKFIGSVILNPNTSFSKIRLATPKVRLFFQLKSKTDDDGVFILDIKNGSGNESKPSRLTYMKKDKEIWCDFIPKYIQLATEGSNFWAVTTVDGTILTYSHVSGKRLLPSIVLGSPISFLESYDKYLMVVTCIGELYVWDMEIKKNVLKSSISPLLELYNKEGLVKSDNITLCAVTSYGIPLVTLSNGSGYLFNKDLGVWQTITESWWCFGSHYWDSTQTGNSSGGGGGSGGSNNKRSLQTMNMFNDEQSIIELLEHKTNEEILRKTRTGRGKYFNKISKNMLMKEGFESLENTISISHLENRILCCELLGENKDFHKFFTTYVQRICELGFKAKLFEVCDELLGPIDTDTAKPPNENNWEPKICGFDKRELLKEIITSCSQFRDAQRVLVHFGKKIGVVIDES
The following text describes a protein:
Function:
The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRHLGRLQYATEPPINRGDGIIYIPFHEYQISVSNDNTRATSRGRVANTAPVQLTSTSKEGGVHEQLGHCELVMFRNNYDGDTVTFSPTGRLFQVEYALEAIKQGSATVGLRSNKYVVLVALKRNADELSSYQKKIIKCDDHMGLSLAGLAPDARVLSNFLRQQCNYSQLVYARDLSVVKAGQLLSDKAQKNTQSYGGRPYGVGLLLAGYDNSGAHLLEFQPSGNTLELYGAAIGARSQGAKTYLERVMEEYLEIEDADALIKHGVEALKHSLKDETLSTKNLSIAIVGKDMPFTLYDGEAVAAYL
The following text describes a protein:
Function:
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
Sequence:
MAAVLLRNTTCGIRCLTKGPAFISTTATISSSHGFGLLTKLRRSYGTTISQDLLNKKVQVYQSTSKDPYLNLSIEHHLLQHSHPESYVLFLYINDPCVVIGRNQNPWLEVNLPALQEAEDIKLVRRRSGGGTVFHDHGNVNWSVICPPAVFDRDRHAEMVVRALKDLGVTTAKVNERHDIVIAGDGRGNGQDIFKVSGSAYKLTRLRSLHHGTCLLNSPRLKNIGKFLRSPGEPYIKARGVESVRSPIRNVDVDTEEFTKGVVDEFRAMYEEQCGEDVTVKCVGEEDVKNMDNIRKGMDELTSIPWIYGQTPQFTFSSRPTEDDPRERPPLDLDVQSDFNVQFTLRHGEIQTANVSGLKYEGTAMDGDIYDGMISQTLAKGSEDDSAVKLYEIKDWATVLKSATAGQAFKVSDSSLNSISEWLNKVFPGNHFR
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.
Sequence:
MQALLGIDIGTSGCKALLIGIDGAVIAADTASYPLSQPQLGWAEQDPELWVEGARRAVAGALAKAPTLELLCVGLSGQMHGLVSLDAGHQVLRPAILWNDQRNSAECEQITEAAGGLKGLLAATNNRMLVGYTGGKIVWMQQHEPDLFARMTTVLNPKDYLRLRLTGEVATEVSDASGTGLFDVRARQWASDLIENVGIDRALLPPVFESQVISGQVSAVGAELFGIPKGTPVAGGGGDAVIQTFGSGVIAPGELQTTIGTAGILAAALDTPQANPDGRLQVFCHVVADKWHCMGVSLNAGGAMSWFRDTFYVGVNAAVPSFDQFTPSDQITPSFEQIVAEAAASPAGARGLLFLPYLNGERCPHPDPAARGAFIGLTACHNRGDVARAVMEGVVHALVDMHTLMKPLGINGRVVKTSGGGARSPLWRQMQADIFGCDVLTTKGAAEGAAFGAALVAGLAIGVWPDATSATANCRIITREPPNPATAAVVAEAQRIYRTLYPALRETFAELGDPTFM
The following text describes a protein:
Function:
Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MSRRVAAALVVLCAATTVAVLAGDEDDITLPGCRSRCGNMSIPYPFGVEAGCYLPGFNVTCRRRNGDGPAAAADELLFLGDGTVQVLEISIPNATVLINSSAGYFDGDKYVSLSSPGTWSGALGSGDGDGVGVYSLAWGRNKLFAMGYNVQVRLEADNETSSVCVSLFFEGNFAAPTDDCAGFLCCQSPIWDQRTSYRFKALSLNGSAASLESDTYAWILDSELRFQYGAPQKDALTLPALLDWRINHTTCHANASSPACRSRHSFCHDGSLEVCRRNDSLCHNSTAGFGRAHICRCDEGYRGNPYLPNNGCKDVNECDHPDTYPCHGICTNTDGGYKCECVPGFAGNASVPTGCKDIDECAHPHLYPCYGVCLNKMGSFDCQCKRGTYGDPFTKGGCSYLTVWEMGLAIGGGTGFLLLALGAPIISRKIKLHKAKRKKERFFKQNHGLLLQQLVSQNSDISERMIITIGELEKATNNFHPSHEVGGGGHGVVYKGLLDLQVVAIKKSKIIVKREIDDFINEVAILSQINHRNIVKLLGCCLEAEVPLLVYEFISNGTLSHHLHVEGTISLSWDDRLRIALEISKALAYLHSSATTPILHRDIKSSNILLDDNLTAKVSDFGASKYIPIDRTGVTTDVQGTFGYLDPMYYYTSRLTDKSDVFSFGVLLIELLTRKKPYAYRSDDGDGLVSEFSSLLDQGTLVDIIDPQIMEEDKQVDEVAKLAAKCTKLSGEDRPTMREVEMALQNLRATEKHAHNNTTSTNKYEKGKTSQYMPFGGLAIETSRQYTMEEEMLLSARYPR
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MASGSTPIPSTAESAVARNGGHLSSFGGDSSPAAQAFLRSQWPWLAALGFGAAGALAYSVFREPAVTQRVWLEFGVDGQPVGVVVVGLHGGDAPHTADNFEALACHSPGFGYAGVPVHRVMHGWSVWSGDVTQGDGSGGVSAYGASLPLESWGAKHRRGTLSMVLDEDSRLRSQFFFTLVTTPALDRKAAAIGKVLEGLEVLDRISRLPTREGQEGRPKQDVRILRCGVVEEQAAHHDEKPAEQRGGRASAREGAGTGAAGGVSTAVKSWGLVFGLGY
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MQLRDGIIELNSTGYFYYTMEFPRPYDVVIYFVAPSCKLCNDLNEHYQKVAKFYADSGALYKSESKRAVFFATMTFNDKTKQVFEQLGFISAPNLFVSQPHIVFVPQDERERYLRDMKWTISYTDGTVTAHKFLEFINKRTARQVDYKASTSEALTVIGVLLGALTVGALLFFIARPLFLNPKLWFVGSIIIFITCLAGVVYNIIHNVPFFSQNNRGGLQWKTNSGRQQLGFEGLFLSLGMTFVGLTMVLIMKLKVLVRHRKIDPLIERSIYLFLFLSIFITVQFVEENYRQKSHYNPIYWPPKHYIKGPLNRDQGNSF
The following text describes a protein:
Function:
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSVFASLVEHLADLLQPLFGASAAAAAIILFTALVRLLVHPLSRAAARGQKARTRLQPRIAELRRKHAKNPEKLQRAVLELHAEEKVSPLSGCLPSLCQIPAFFLLYHLFSSSTIGGEVNGLLSHQLLAAPLGGRWADAFGDGGLLGGAGLVYVALFAVVAGVATFSYRLTRRTMADRPVLPAGDAGAVPGVGALTRVMPFMSFFTLVTVAVVPLAAALYVVTSTTWSAVERAVLYR
The following text describes a protein:
Function:
Tumor-associated antigen.
Miscellaneous:
MISCELLANEOUS: Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL). Also found in colorectal and breast carcinomas, head and neck squamous cell carcinomas and melanoma.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQTLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSPVEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNPTF
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
MAEQSKRGSQMENGDHGHSGKKARAQAMSNGVVKQEQQEVGEIEQEEEEEEEPEEGEVSQGSGGGAGAMVAVEAVETEPQINLSFGLTLFHCRACLLPLKPPTKSCLSMCSCFWLQCEAGHVVCAACCNNHGQACGGATIFSPCVEVDAFVRGAKQPRSYEEFGCKDTVVYFEAAAHRRACPWAPCSCPDPGCGFFTSPAGLVVHFAFAHSWPVTEVRYGKPHRLALPPPQGWHVLVGKGGDRCVFLLSPCALGEAAAVALVCVRANGGEAEGAP
The following text describes a protein:
Function:
Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKAILMMTFGSPEEITFEGVADFFTNIRRGVRPQDHEIQTLYDNYVRIGGTPLQKITRQEVTLVEARLGNEYSVYFANKFSSPFIPDVIGQMEADGIEQCICLILEPHYSFYSVMGYEKFLESKQIQFLVIKDWYQEEALLNYWADEIAKILKEEVKQDSFKVIFSAHSVPIFALDFGDPYIDQIFENSKLVAEKLGLSSEQYTNTWQSESDIGIPWIKPDVLEYLREQTEHPDHYIFVPISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMPNTDSRLIDALVNTVRVNENQEFKEFLPEEETFDELVPSDETKNILAESEDLQMPEFVKKLIEKKGRENVKMPYLIKKMLEKAGKLPKE
The following text describes a protein:
Function:
Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTVLSFFSFLFLLACVISVEIVCPYTKVEESFGMQAMHDFLLCGKRACFDHLSSPGVVPRTFTGPWFVASLAMLPFLCDVNYVVRFLLEPLKYVVAGDVAWFVRLVEDVGLVGSSEELFALFPMLASNMCRVTLGVVTCCALGYVGCGIDSAAKWEKFKSTSSRVAAARCPVSMRHVSSVFYLLCLSQFHLVFYATRPLPNTYGLIMCTLACGATCRGKYYWAIALLSATSALFRCDVLVLLAPYSLFLLLRGDITLLRGVAAGICSVAAVVIFSIGMDSYLWGRLVWPEAVVLLFNTAENQSWRWGRLPVYWYVLVALPRSLLFLYPLWLTLVCMGWGNIYFALHRLSGAGRREGTTSEEPSPAAAHCALWVFLDTSERYADLLVPSSLFIVLYSLLPHKEVRFLMIVFPWLLVPLAAAGTRLWDECFARPLSSCTLEVTKGKGIVQGRATLVKWRNEGANLRSRGDGKGGFNVRPRWFLACLTRRSVIASLIVLLYTVQLATVLLSVYLSADNYPGSEALRRLHHAVEKDVRNSSSCLSRRLTTRTNRSNSISVFIDAYAAMTGISRFQKVHKIQRRNPTNSTFATAGASQQVSDRFVKLLTFPFRALMSVGRSIVVGDTGLHDEELFGTGNVPSPAVVSGGDSSRTEVSDAFSLSILLQRRGLEMQYIKEEIRFDETNDLYNSEGIDYVISRYSQRELHRKHGEYNEIAVVHESNRLHMLKLRLMQLFWLRKRHEVADQADPEGKPFLIALGPRC
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
Subcellular Localization:
Cellular thylakoid membrane; Single-pass membrane protein.
Sequence:
MFDFDATLPLMALQFVVLAFLLNAIFYKPMNKVLDERADYIRTNEEDARERLAKAKAITQEYEQQITDARRQSQAVIADAQAEARRLAAEKIAEAQRESQRQKETAAQEIEAQRQSALSSLEQEVAALSNQILHKLLGPELIK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (Probable). This subunit is involved in DNA promoter recognition.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSNLSIDERWKVIEAYFKSKGLVRQHLDSYNDFVRNKLQEIIDEQGEIPTEIPGLKVRLGKIRIGKPRVRESDRGEREISPMEARLRNLTYAAPLWLTMIPVENNIEAEPEEVYIGDLPIMLKSAIDPISQYTLDKLIEIGEDPKDPGGYFIVNGSERVIVTQEDLAPNRVLVDTGKTGSNITHTAKIISSTAGYRVPVTIERLKDGTFHVSFPAVPGKIPFVILMRALGILTDRDIVYAVSLDPEIQNELFPSLEQASSIANVDDALDFIGSRVAIGQKRENRIEKAQQIIDKYFLPHLGTSADDRRKKAYYLAYAISKVIELYLGRREPDDKDHYANKRLRLAGDLFASLFRVAFKAFVKDLTYQLEKSKVRGRKLALKALVRPDIVTERIRHALATGNWVGGRTGVSQLLDRTNWLSMLSHLRRVISSLARGQPNFEARDLHGTQWGRMCPFETPEGPNSGLVKNLALMAQIAVGINEKIVEKTLYEMGVVPVEEVIRRVTEGGEDQNEYLKWSKVILNGRLVGYYRDGEELAKKIRERRRKGEISDEVNVGHIVTDFINEVHVNCDSGRVRRPLIIVSNGNPLVTREDIEKLDSGSITFDDLVRQGKIEYLDAEEEENAYVALEPSDLTPEHTHLEIWSPAILGITASIIPYPEHNQSPRNTYQSAMAKQALGLYAANYQLRTDTRAHLLHYPQRPLVQTRALDIIGYTNRPAGNNAILAVISFTGYNMEDSIIMNRSSVERGMYRSTFFRLYSTEEVKYPGGQEDKIVMPEPGVRGYKGKEYYRLLEDNGVVSPEVEVKGGDVLIGKVSPPRFLQEFKELSPEQAKRDTSIVTRHGEMGIVDLVLITETAEGNKLVKVRVRDLRIPSIGDKFASRHGQKGVIGMLIPQVDMPYTVKGVVPDVILNPHALPSRMTLGQIMEGIAGKYAALSGNIVDATPFYKTPIEQLQNEILKYGYLPDATEVTYDGRTGQKIKSRIYFGVVYYQKLHHMVADKIHARARGPVQILTRQPTEGRAREGGLRFGEMERDCLIGFGTAMLLKDRLLDNSDRTTIYVCDQCGYIGWYDKNKNKYVCPIHGDKSNLFPVTVSYAFKLLIQELMSMIISPRLILEDRVGLSGGKGNE
The following text describes a protein:
Function:
Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
Sequence:
MGICSKRNKKLLGFISGVPIKIQIGEDVVEAADLNFLCVQKGFKKFSFGSLGSFMIDEMRRRVDLEGVSKAVYLTVSERSTPSITCQPWYRALKEEKQPLPAATTQTPGLRPMLPCDVPAVTKLIRSYLRQFRVSSYLEEADVTHWLLPRDKVVYSYVVVNPSTEFVTDFFSFYARKNSDLNVAFSFYHVARDTSTKTLMSDALVVAKESGFDFFGALDIMGDRSFLKKKLKFVKGKTLAYYHFSNFNLPHLKPREIGVNIKAT
The following text describes a protein:
Function:
Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Nucleus.
Sequence:
MSNSTEQALLQIAQQIERAVDDEIDRIDQMDDDEILAIRQKRLKQLKEIQARRDEWLRKGHGQYLEIAEPKEFFDNVQSSERIVVHFMRRSTPRCEIIERHLRTIAHEHFETRFCYVDVERIPSLPERFNVMMLPTLMLVEKGHTFHSIIGFDEFGGTDDFTTDTVTQVLAHYGMVNEKGMFAADQNDE
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MITIKRKREKFFYFLLIPSSVVVFTFILILSVLVYNSIPILEKVGLSIYTKNIWNPIYDQYGGLAAIYGTIVTSVLSVMISIPFATAFSIFVNDISPKKVKSFLVNLSDLLAAFPTVLYGFWGLLSLGPFLSRTLFTFLSSHVGLHQTTNGPSILLASIILAIMITPFASSLIREVYFQVPRSFEEAVYSLGLGKWELITLKLSYIKKAFLGAYALAFGRAVGETVAVSLTIGNVLNISPNLFEPGYTISSLIISQFGTAYGIQYNAMFALALFLVVIGFIFVIISKLIVRMRS
The following text describes a protein:
Function:
AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Note=In sucrose cushions fractionates with both the inner and outer membranes.
Sequence:
MLELLKSLVFAVIMVPVVMAIILGLIYGLGEVFNIFSGVGKKDQPGQNH
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MSCCGGNCGCGSGCKCGSGCGGCKMFPDLGFSGEKATTEAFVFGVAPVMKNQYEASGEGNAENDACKCGSDCKCDPCTYIKDPEYPMQSLEDLRIVTEESVEVDDDKSYVRITFRPTVPHCHLPNLIGVCIYAKLLKSLPARFKVDIRVAPGSHATEASVNKRLGDKERIAAALENPDIMSLLN
The following text describes a protein:
Function:
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with tomm-22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MSDTILGFNKSNVVLAAGIAGAAFLGYCIYFDHKRINAPDYKDKIRQKRRAQAGAGGMAPRRPAAAGNDAAPDVTDPSQMQRFFLQEVQLGEELMAAGNVDEGAVHIANAVMLCGESQQLLSIFQQTLSEDQFRAVVQQLPSTRERLAEMFGAKADEAENEPPMVQYLGDGPPPAQIQELIDDTDDLE
The following text describes a protein:
Function:
Metal-independent phosphatase active against a broad range of phosphorylated substrates including nucleoside tri- and diphosphates, phosphorylated organic acids, and amino acids. Shows no activity against phytic acid, phosphorylated carbohydrates, and nucleoside monophosphates.
Miscellaneous:
MISCELLANEOUS: Present with 8300 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTKEVPYYCDNDDNNIIRLFIIRHGQTEHNVKKILQGHKDTSINPTGEEQATKLGHYLRSRGIHFDKVVSSDLKRCRQTTALVLKHSKQENVPTSYTSGLRERYMGVIEGMQITEAEKYADKHGEGSFRNFGEKSDDFVARLTGCVEEEVAEASNEGVKNLALVSHGGAIRMILQWLKYENHQAHKIIVFNTSVTIVDYVKDSKQFIVRRVGNTQHLGDGEFVVSDLRLR
The following text describes a protein:
Function:
SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.
Sequence:
MEILENEPALHYVTAPVHAIFSVMRVLHTADFHAGRLLKGFDRTPEIHDALVEIAGLARTERADAVLVSGDLFDTGNPSADAEAAVFDFFLRLRDAGIPGVVIAGNHDSAARLDSVAGLLGWVGIQVVAQPSGDPLAMVREVATKSGERLRVGALPYLSERRLVKAVDVLGGDLGAQRQKYRENMGFFLRELGRGFEPGAVNMLMAHTTMDGAVPSGSERTFQLDLTNAYTVSGLQLPPGAQYVALGHIHKPQTVSDAPLACYPGSVIQLDFGEAGEKKQINLIEVEAGRPARVEGIPLASGRDLRTVYVDLDNVERRLGEVKASGFTGLLKVVVRAPAGTALPGLKDRVLNITPNALSVELDAQQEDLAVPELRREGLTLMELFERYWQEKRGELPDDVRAAFQTAESQAREGAQ
The following text describes a protein:
Function:
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity). Within the HOPS complex, contributes to the normal development of gut granules in embryonic and adult intestinal cells. Required for endosome/lysosome fusion. Required for early embryonic development.
Subcellular Localization:
Lysosome. Early endosome. Late endosome. Apical cell membrane; Peripheral membrane protein. Note=Localizes to lysosome-related gut granules.
Sequence:
MAANEDRDDAAAILNWEGTSEIKSANEYSRNLLFSVLDSLDGNKTIVWDRDRSVMHRVNLFAGASVLAAHGVVANHSIETKKSASTPHVVFFLAPTMVSLDLLCDYIDNVRNDSKILYQVFFIPEAWFVVRESLKTRAEGKYWERLESVKEIPLCWLPRDGECLSLSSPQIAARLLINGDWTHLHKCAVALNQLIDMCRGRSSSSNQRPMSIYAKGKWASDVAKMMGKIRNSAEADSMTKNLDPIEGLLKINRIVLIDRWMDPLTPMLSQLTFYGLLDEIYGIGMVNSVKVPEMEFKNEKDGDPFQEKEVYLIDEVYHRLKHSHINAVSIEASKVLAEIRDDEQFDRDKMSVAEYSVLVKKMPKIINRKKMIEVHMRLAEMIQSHVYCKQSDSIKLERDLLEYSDSDKAIPLIEDLIFDASPLNAVLRLISVHSLTCGGLKPSVLQHYRRIVNQSYGSSALNKVLKMQKMGLIREKGGGGKMQCEYAQMMFQQMKKNHDMLPEEFSEAKLDDMAYAYSGFSPLLCKMLEEGDRVKWVGWPKTVIGDKSDLIAERDGRGTCVFVIGGLTRSELAIIRENLPNVALITTSALITGDKLLNNITNI
The following text describes a protein:
Function:
ppGpp hydrolyzing enzyme involved in starvation response.
Sequence:
MGSEVAQLLEAADFAARKHQRQRRKDPEGTPYINHPIGVARILTHEAGITDIVVLQAALLHDTVEDTDTTLDEVELHFGDQVRRLVEEVTDDKTLPKLERKRLQVEHAPQSSPGAKLVKLADKLYNLRDLNRCTPEGTLSPTCSEGKRRGIHLLKAQDGLNTESRNTSSGRHRW