lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.
Subcellular Localization:
Cell projection, dendritic spine.
Sequence:
MDVFGFGKIAKLSSHRAKSSGWPPPSGTWSLPQGTPYGWEMATNRDGRDFFISNLTQPATFEDLRIESCQINPPVPRNIEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLVPGDQIIMINDEPVSSAPRERVIDLVRSCKESILLTVVQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDGGTSIKDVILTLQEKLSIKCIEHFSLMLEQTTEGAGTKLLLLHEQETLTQVTLRPCAHMMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDTALRLAALQMYIATVTTKQTQKISMKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSGLQAKVHYLKFLTDLRLYGGRVFKAKLVQGEKHSDVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMYTEDDITVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNVTNKTAANREAGNETRIKYSYQDCDWNYLPKSTIFGFEENQENQDSQQIFSDLKQRTTNVVGSPLCHTDHRSLYIETTFNSGELDQQLTKQCEHIDLENSLNVRQPSIISISGLEHTITAQDSPRSAKVSFIFGDHNLDTINPQTLGYERLVDESPEIIDKQSIIYFNNANDIKDLELSPDAESINFAANAVYANISQRKNFGNAEGIEEPLLHDICYSETTDDAEDDDEASCEEDVMVAEENRTDILSMSESSDDIIDLTSLPPPEGDDNEDDFLLHSLNLAIAAPPPGFRDSSDEEDCQNLSKPINELTGAANSISHDDIPVSLIDAVPTNTDEKPKTILEETSDLQKLQDLTVSEENQRDDTSGVTILRAYSPESSSDSGNETNSSEMTESSELATAQKHPEISARTILPVSEDYQSLMEEQTDFSVAKGQTGSITIKATSSLMTRQATELQSKDVPSKQVIHSDNIEMEPETMEIKSVSEYFNKVHMDTLMYSCKKKNKLPDAEAKSHFDVNVMVKKQFGKRPESDGELKTKFETISSKDCQHLANFNLERTAFRTDSQRWYNTADRSAIDKLSTDTHHIKTLPRLSGVGKTETDIMEEINDISLSGLKQDDIFISHANYMSPSKEHTISKADDASTEHVSKLVDPGDNHVAKNISSFQSEGQFSLQSSQCSSVDAGCSTGSSSCPTPLESPLCTGDVKHILSDASVKSSVLIPLDERSSMLPNLGAPFTELHQQTEAVCHRMSLPVIHAPVNAEPVFGTLRDGCHRVSKIKETTAFTEPAKGRKAGGLPAAASKHPKGDFTIPSNICLESHVPIQNQDFIHPHQGNLACAADMTLHPYEIGGSLKMPHNRKVLRRSSSVISRSSGMEWADKNISSVSLCLDSTETGLKSRSEKQVEIPLVRKISKSCSQSSMNSISESKKFTATGSIQKVQKQSRTLPLLKLDASNWRCRGPFSYCFQNRGNNGEEEDEECEEADNGNNNEIKENSCVYISQTPAEKVGDLLLSPECRNKELESPMVTTNTTGKQDIDITARQAEINYHDMDFDEKIARINALKEKVYAIPDGFHAAQKDANELLCLIRSNVGKGEDASVEMYDLKLSQYKYRLSIESRELGSACRKMASADKGPEEMLLAMNSSFQILCSLTEACMRLVNAMNSEIQQQEIVAKIDEVVINYICLLRAAESTSAKMFNDPSIKVLARQSSTMAAVVSTLTRSLKMLLNK
The following text describes a protein:
Function:
Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Required for cell cycle exit in eye imaginal disk and hid-induced apoptotic cell deaths that are part of normal retinal development. Activation of Drice in eye imaginal disk by either Hid or Rpr is almost completely blocked by Sav expression.
Sequence:
MNYLTILLCNRKPTMLSRRNKEKSQHKEGVVGKYMKKDTPPDISVINVWSDQRAKKKSLQRCASTSPSCEFHPRSSSTSRNTYSCTDSQPDYYHARRAQSQMPLQQHSHSHPHSLPHPSHPHVRSHPPLPPHQFRASSNQLSQNSSNYVNFEQIERMRRQQSSPLLQTTSSPAPGAGGFQRSYSTTQRQHHPHLGGDSYDADQGLLSASYANMLQLPQRPHSPAHYAVPPQQQQHPQIHQQHASTPFGSTLRFDRAAMSIRERQPRYQPTSSPMQQQQQQQQQQQQQLQHTQLAAHLGGSYSSDSYPIYENPSRVISMRATQSQRSESPIYSNTTASSATLAVVPQHHHQGHLAVPSGSGGGSLSGSGRGGSSGSVRGASTSVQSLYVPPRTPPSAVAGAGGSANGSLQKVPSQQSLTEPEELPLPPGWATQYTLHGRKYYIDHNAHTTHWNHPLEREGLPVGWRRVVSKMHGTYYENQYTGQSQRQHPCLTSYYVYTTSAEPPKAIRPEASLYAPPTHTHNALVPANPYLLEEIPKWLAVYSEADSSKDHLLQFNMFSLPELEGFDSMLVRLFKQELGTIVGFYERYRRALILEKNRRAGQNQNQNQ
The following text describes a protein:
Function:
E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP (By similarity). Also mediates ubiquitination of STX8.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MAGPGPGAALESPRQLLGRVRFLAEAARSLRAGLPLPAALAFVPREVLYKLYKDPAGPSRVLLPVWEAEGLGLRVGAVGAAPGTGSGPLRAARDSIELRRGACVRTTGEELCNGHGLWVKLTKEQLAEHLSDCSLDEGWLLVCRPAEGGARLVPIDTPDHLQRQQQLFGVDYRPVLRWEQVVDLTYSHRLGSRPQPAEAYTEAIQRLLYVPPTWTYECDEDLIHFLYDHLGKEDENLGSVKQYVESIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLLLTVDTTDDNFMPKRVVVYGGEGDNLKKLSDVNIDETLIGDVCVLEDMTVHLPIIEIRIVECRDDGIDVRLRGVKIKSSRQRELGLNADLFQPASLVRYPRLEGTDPEVLYRRAVLLQRFIKILDSVLHHLVPAWDHTLGTFSEIKQVKQFLLLSRQRPSLVAQCLRDSESSKPSFMPRLYINRRLAMEHRACPSRDPACKNAVFTQVYEGLKPSDKYEKPLDYRWPMRYDQWWECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNPSCRDFAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLEVMEGVDKETFEFKFGKELTFTTVLSDQQVVELIPGGTGIVVEYEDRSRFIQLVRKARLEESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDTRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPARIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAIDTDMSPWEE
The following text describes a protein:
Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chain mediates the binding of dynein to dynactin.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MDRDQKKKELEQTKNEMRRKLEEYKERNRIMASKTTPTATTTSTLNTASTPSPPVAQEDFNSIMNSIDSMVPTQATPSSSSTISTSTHAESQKSNYIRPTLTIQSLVIEHDFPPKEIPMYSKGTQTMTDADTSNTNNTPELEAPNKNKTKYQLLQQQQQQQQQQQSSLNQDMQNLSIGTDSINGDGSSTSVANSANIDDDDKDEIEIPELDENEKKDILESDSFKSFFGRSSRVIERALCLDDSIDILVDYTISDENSKGTSKELKLLATLSDERWTKHRSITDISWSTKHPELVVSSYSANEAGSHDPDGVALVWSVNNYFQKPEYVFTCQSPVMTTFFSKFHSTLIVGGTYSGQIVIWDTRAEAKPVQKTPLSSVGHTHPVYSMAVVGSANANSLVSISTDAKLCSWNLENLSQPIETIELNSSNTNSANKAGGGGSGGGAPNMSIAVTSLVFPENELNHFYIGTEEGVICQAGRHGNRIVMNERYKGHFGPITSVDLHPSKGGADFSQYFLSSSTDWTCKLWSSKKETPLYSFEDYVDYVYDARWSPVHPSIFSTGDGSGTLSLWDLNQDLEAPIFRHKISNRSVNRLAWSHDGKRILVGDSGGSLSLFDSSEFSSPTSEEYSQFEDVMTKMVNKSRTSDSPLLGEGENQE
The following text describes a protein:
Function:
Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but also accepts a lysine residue in the P1 position, leading to the activation of trypsinogen and chymotrypsinogen A (By similarity). Can catalyze hydrolysis of the major structural proteins of basement membrane, elastin, collagen, and laminin. Thought to play a significant role in virulence.
Subcellular Localization:
Secreted.
Sequence:
MVVFSKVTAVVVGLSTIVSAVPVVQPRKGFTINQVARPVTNKKTVNLPAVYANALTKYGGTVPDSVKAAASSGSAVTTPEQYDSEYLTPVKVGGTTLNLDFDTGSADLWVFSSELSASQSSGHAIYKPSANAQKLNGYTWKIQYGDGSSASGDVYKDTVTVGGVTAQSQAVEAASHISSQFVQDKDNDGLLGLAFSSINTVSPRPQTTFFDTVKSQLDSPLFAVTLKYHAPGTYDFGYIDNSKFQGELTYTDVDSSQGFWMFTADGYGVGNGAPNSNSISGIADTGTTLLLLDDSVVADYYRQVSGAKNSNQYGGYVFPCSTKLPSFTTVIGGYNAVVPGEYINYAPVTDGSSTCYGGIQSNSGLGFSIFGDIFLKSQYVVFDSQGPRLGFAPQA
The following text describes a protein:
Function:
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MGTIFAGKTGQREPRPRGAPSSPAGLARPRAMEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTVHVRLNDYLDIICPHYEDDSVAEAAMERYTLYLVEREQYQLCQPQSKDQVRWQCNQPNARHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHHQEDQCLKLKVTVSGKITHSPQAHANPQEKRLPADDPEVQVLHSIGHSAAPRLSPLAWAVLLLPFLLLQTS
The following text describes a protein:
Function:
Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (17 - 22 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to heparan sulfate moieties and chondroitin sulfate B of the host cell surface proteoglycans. After attachment, the virus is internalized in a clathrin-, caveolae- and dynamin-independent, actin and Rho-GTPase-mediated pathway and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope (By similarity).
Subcellular Localization:
Host nucleus. Virion.
Sequence:
MTYPRRRYRRRRHRPRSHLGQILRRRPWLVHPRHRYRWRRKNGIFNTRLSRTFGYTVKATTVRTPSWAVDMMRFNIDDFVPPGGGTNKISIPFEYYRIRKVKVEFWPCSPITQGDRGVGSTAVILDDNFVTKATALTYDPYVNYSSRHTIPQPFSYHSRYFTPKPVLDSTIDYFQPNNKRTQLWLRLQTSRNVDHVGLGTAFENSIYDQDYNIRVTMYVQFREFNLKDPPLKP
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MDRFKQIDASNSSIGALLLQDEEVVSLQDSIGLYDGKEKTLHQNNGTVYLTSHRLLYVDDLEPHRYSCSLDLSLVKQSEYYAGFLKSSPKITLTLAKPDNGAEATTDNLNLQQQQQQARSAGTSLQTNSAPLSKTPSRDWRANAPAADSTPLDASGYNWICAICGFSNASTRSVCELCGVTKEPARSTPKRNLHPSQLREAARLDPFSSPAKPDSISKPQDNAAFTPTKKKDDGIACDVCTFLNHPSMTKCEMCSSHLGSSWQQEQATALASATSLTAPSTPIRKSIEADAMSLRASTAPSRASTPSSAVLSSSNDFVKLSFRKGGDKAFYSVLKATLRAKAWVSNMPGIGAGGSKNSEADSARATRVAAGMVDLDGRSAALKRVGIDGILSSVDSTSRTQNDDMQGALKDLEALMRKAKQMVEFAESLNAKLTKQEQAAAAAREAGMPDTAPQPDQQAATLIRSSLVQLGLPAPAVTEDMARDQEEYHRQLAHELAGLLLGNPSGGRRSGLMGTGKIAAPGKSSELLPRVSDDNLQGRGLVGLDEVWCVWNRARGVALVPPQALRSAATFLPDMTSPSIHMKTFRSGLSVLHTPRYSDNAFTSRILHYLDTLEWEHKMKRIEQAQSLRISEPGSISAASDQTASTEEASYGDNLSPWGAGASILEIAEKEDVPILLINEMMDMIESKTGMVVRDDGGPNGTRWFVNHFSRA
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MAEGCGAEAEPATPAQDGTTQGLEDRRLLRSQYLAVKGQINDEKDEMASADSVKFKAIFTQVESLHQLVQRPREQIADAEALLDITTSLVTSVRSHSALGITPSHLVAGLLKKFGSQGSVDGEGASLSWGDVGLDTSHVFMAVLGCCTMVGPMKAEVKPRMVRTIRKRTAWTLKNACPEQLADPSETSKTDTDRNMAVLFDVLRKKKNARLENLILNRKSFAQTVENIFALSFLVKDGRVEINVNDEGHHIVYPRNAPAASAIVSGEVVYNHFVFRFDFKDWKLMKEIVLEGEELMRHRSSRSMAQGNNHPEMPAQSSFGENSDAEMPAQGSFGGNSDPEMPAAHSTFGGNNNPEMPAAQSTFGGNNDPEMPGHTTPIRKLCRNRGLVKDARQDETTAADNQEMDVEDKTVSIATSTLEAMVNKEFIEYRHETAKTYKRRRLFQD
The following text describes a protein:
Function:
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.
Sequence:
MALLRAAAAALRRRARVAALPAISPFPHTHSSSPSPSPAPNPPARRHLITLSRRSPCLHPPSASAAASSFYIDRILLPSSFSHPLSTSSRDKDTDKDKEDNIPPPAPASWVERWLPEAARPYAMLARLDKPIGTWLLAWPCMWSITIAAMPGELPDLKMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTKSRPFASGALTPSQGVAFLGAQLLLGLGILLQLNNFSRVLGASSLLLVFSYPLMKRFTFWPQAYLGLTFNWGALLGWAAIRGSLDPAVILPLYTAGICWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDLTKQWISAFGAASIGSLALSGYNAELAWPYYPLLTAAAAHLAWQISTVDLSDRADCNRKFVSNKWFGALVSSGILLGRLAS
The following text describes a protein:
Function:
GTPase-activating protein for Rho-type proteins.
Sequence:
MNSGTTLHLDRLSLETPSERTCFCIKCWESVPSTSQVWFGGKCWHSDCFKCVNCNKKLDPSSEDFSQDDQKQIFCKLCVDICNGCSTPICEFNAVSNSQANHPCCSNCRAFINSNAFGKFKGQHYCLPCLRKQDEENQKAVMESASGFIPLRNIAQTAENTSLTGQNQGFQNPHFIASDSPSSVLSGRMQNTSSPTNSLRPQLKVQTNGYETPGDINSAKSYKDIQKDFLLKPKNSFVKTSPSPLANGPSFRSANASPFDSCDSFHSGSSIPIEPVSSRQSSVVNNNSVQQPVAYHAFVQSPTENGTLPQLPKNESVVNPPPLRRSSTMNYKSVSTTTSPSKYGYVSGRIALSPIHLRGALRDVTNKCNLKVPRNRNSLSNLDEYYVNGLESDETPTKARFPRYPTVFNKLDDKRLSSEPNGLKKRLTNSSNYEASPRAKSLNLSQVSLHQACEPEYNRSSLVRASDVFTSNVFDATEESANELAIRISELQAEVGTLLLEATSLASIIEQQTPVSPEAFKQELVADLNYRLDYLRKSFQPELSTLLLRRDALSTTVSKLQNAYSTVMEETAYLNVKNTELVSLNNQLERELAYLREQQHKKRTSSSFGIFNNDKKSNRTISTPSPRESFSRLQMVASSLGFRPKDNKDKESGGYNKRNSKIDLKKSFSKRFHWKRDSPHMSSTPSISEEHLASEEQEDFVPAVGHCKLCGKYSNELRAHYQDCVSSTIDRQYQSKKSESPVWALNPDDFDQNRLTLLRVPTLIVSCINFIESYGMDFEGLYRKSGATSQMKKIVALLRNEDTVLDPSEDISAVTSVFKQYLRNLPNPIITYDQYFPFITAANCASFQDKLDGFIMVIKSLPPAHAEILQLIIRHLARVAAYSHANRMTSKNLAVVFSPTLIRDPDNSRDVIDMTVKNYSLAFLIDHVHEVFA
The following text describes a protein:
Function:
Involved in the degradation of lignocellulosic biomass. Catalyzes the oxidative cleavage of glycosidic bonds in cellulosic substrates via a copper-dependent mechanism. Degrades phosphoric acid swollen cellulose (PASC) to oxidized cellooligosaccharides with degrees of polymerization of 4-8. Also shows activity on agricultural fiber paper pulps such as flax pulp. Is not active on chitin.
Subcellular Localization:
Secreted.
Sequence:
MARRSRYISLAAVMATLLSALGVTFLLGQGRAEAHGVAMMPGSRTYLCQLDAKTGTGALDPTNPACRSALDTSGATALYNWFAVLDSNAGGRGAGYVPDGTLCSAGNRSPYDFRGYNAARSDWPRTHLTSGSTIQVNYSNWAAHPGDFRVYLTKPGWSPTSELGWDDLELIETVTDPPQRGSAGADGGHYYWDLALPSGRSGDALIFMQWVRSDSQENFFSCSDVVFDGGNGEVTGIRGSGGTPTPTPTPTTPPTTPPPTHSGSCMAVYNVENSWSGGFQGSVEVMNHGTEPLNGWAVQWKPGNGTTLGGVWNGSPTRGTDGTVKVRNVDHNRVVPPDGSVTFGFTATSTGNDFPVGTIGCVAP
The following text describes a protein:
Function:
NAD-dependent deacetylase, which plays an important role in the regulation of transcriptional repression.
Sequence:
MSKQTQCVHIENCNINYESIDIQLYDNENITIPNCYKCSSQDNILICLECGIVVCMEDCKLHSNHSIFKIFHGDDKTLWCNDCNELIKESTMIEKCTKNSDLINKKLKDIENLFKVMKLFIYYDQRNLKYNKNFDSIDNSIKDIIKNSNIIKNEIKIENEIEIENNKIKEFIKLIKNDKCKNIIVLTGAGISVASGIPDFRSVETGLYNNENVSKFKLPFKEAVFDIDYFKFNPEPFYQLSKDLYPSGKFKCTPVHYFIKLLSDKGLLLRNYAQNADTLERIAGIPLDKLIEAHGSFAVSRCTNCGLEYSQEYIKDSIFNNDPLKSVVPRCKVVQCNNAVIKPDIVFFGESLPPIFNQNILDDINRCDCLIVIGTSLKVQPIASMVHFFPHFKNIPRLLINNQIVGENSFGGFNFNNNKNFDFKMIGDCQESVLNLSKLLNWDTELLNLINSKNHN
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPMIPPALRRTQAAATPTTSSPAASSSTTATLDSQSLCALPRIRVSASTLNSIVTPVKKITSETDVEAWKASAAYSIYTLFLQRVCEACVGKPTRLPTRSTDAPVTPVDKLVSLLWELDSWTQEIEPHEKPQRFGNLAFRDWGARLEERIDSLLSDLLPSRLHAFAVELRVYLLDSFGSFTRIDYGSGHELAFFAWLCFLYRLGFFDASEEQEQDETLADIQVEERIGLDIFPLYLMVVWKLQDRYGLEPAGSHGVWGLDDFQFLPYVIGAAQLRRQSGLRPNQVIGASSHASILQTQLATRTDPASLISTTLVLPASSLVGTQVEVPLPNLYLSSLLRIHVLKRGPFHEHSPLLNDIASSVPNWLKVYFGMLKMYAAECLAKKVVVQHFAFGGVGWVWTHQAHSELPRLATPSAPVAARRHLPLGGIQGNMTSMGVPTPRITRPPATPDSFDHPLRLPPRSTPSRPSTTPSVPPLAASTRPAPKPE
The following text describes a protein:
Function:
Promotes the exchange of CDC42-bound GDP by GTP. Controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. CDC24 may be involved in the initial selection and organization of the budding site.
Miscellaneous:
MISCELLANEOUS: Present with 1010 molecules/cell in log phase SD medium.
Sequence:
MAIQTRFASGTSLSDLKPKPSATSISIPMQNVMNKPVTEQDSLFHICANIRKRLEVLPQLKPFLQLAYQSSEVLSERQSLLLSQKQHQELLKSNGANRDSSDLAPTLRSSSISTATSLMSMEGISYTNSNPSATPNMEDTLLTFSMGILPITMDCDPVTQLSQLFQQGAPLCILFNSVKPQFKLPVIASDDLKVCKKSIYDFILGCKKHFAFNDEELFTISDVFANSTSQLVKVLEVVETLMNSSPTIFPSKSKTQQIMNAENQHRHQPQQSSKKHNEYVKIIKEFVATERKYVHDLEILDKYRQQLLDSNLITSEELYMLFPNLGDAIDFQRRFLISLEINALVEPSKQRIGALFMHSKHFFKLYEPWSIGQNAAIEFLSSTLHKMRVDESQRFIINNKLELQSFLYKPVQRLCRYPLLVKELLAESSDDNNTKELEAALDISKNIARSINENQRRTENHQVVKKLYGRVVNWKGYRISKFGELLYFDKVFISTTNSSSEPEREFEVYLFEKIIILFSEVVTKKSASSLILKKKSSTSASISASNITDNNGSPHHSYHKRHSNSSSSNNIHLSSSSAAAIIHSSTNSSDNNSNNSSSSSLFKLSANEPKLDLRGRIMIMNLNQIIPQNNRSLNITWESIKEQGNFLLKFKNEETRDNWSSCLQQLIHDLKNEQFKARHHSSTSTTSSTAKSSSMMSPTTTMNTPNHHNSRQTHDSMASFSSSHMKRVSDVLPKRRTTSSSFESEIKSISENFKNSIPESSILFRISYNNNSNNTSSSEIFTLLVEKVWNFDDLIMAINSKISNTHNNNISPITKIKYQDEDGDFVVLGSDEDWNVAKEMLAENNEKFLNIRLY
The following text describes a protein:
Function:
May play a role in the immune system, perhaps as a co-receptor on alphabeta and gammadelta T-cells.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MRAALWTLGLGPLLLNLWAVPIGGPGALRLAYRHSTCDGVVLVRHHGAWGYVCNQEWTLAEASVVCRQLGCGPAVGAPKYVPLPGEMAQPWLHNVSCRGNESSLWECSLGSWCQSPCPHAWVVVALCSNGTFRELRLVKGRSPCAGLPEIRNVNGVDRLCVLHVEEAMVFCRELGCGPVLQAPRRDVGVVRKYLACRGTEPTIRSCRLDNNFRSGCDLRLDAEVVCSGHTEARLVGGEHPCAGRLEVTWGTVCDAALDLATAHVVCRELQCGAVVSTPEGARFGRGSGPVWTEAFRCAGNESLLFHCPRGRGSQCGHGHDAGLRCSEFRMVNGSSSCEGRVEFQVQGSWAPLCATHWDIADATVLCHQLNCGNAVAAPGGGHFGDGDAAIWPDAFHCEGTESYLWNCPVSTLGAPACAPGNTASAVCSGLAHALRLREGQSRCDGRVEVSLDGVWGRVLDDAWDLRGAGVVCRQLGCRGAQQAYDAPAPSRGSVQVALSRVRCLGTETRLTQCNVSATLQEPAGTSRDAGVVCSGEVGTASPMARRHGIPGALTLSLHREPQGAAGRGAGALHGGAWGTVCDDAWDLRDAHVVCRQLGCGRALSALGAAHFGAGAGRIWLDELGCQGHESALWQCPSAGWGRHDWRHKEDAGVFCSESVALRLRGGTCCCAGWLDVFYNGTWGAMCSNALKDLSLSIICKQLGCGVWGVGLAGEQALPLCGHRDRLGGQHRVPQAAQLHSVAMPFPPMAPALLRPSRAGLSEDRPQAAGEPLNCSSWLGCPEEGALRVRGGEDRCSGRVELWHAGSWGTVCDDGWDLADAEVVCRQLGCGRAVAALGAAAFGPGSGPVWLDEVGCRGSEASLWGCPAERWGRGDRAHEEDAGVRCWEPGPGPPLPAAPFRTFWVVSVVLGSLLGLLLLGLMAFLILPRVTQAMQRGLGRSEVSPGEAIYDVIGEMPPAGLYEEIMEAEAVLQDEEDGSVVKVDTEAAVSGEVSNLLEGQSIRAEGGHSRPVSQGYDEAAFPLEEMTL
The following text describes a protein:
Function:
Transcription activator involved in the spatiotemporal regulation of flavonoid biosynthesis specifically in the corms of Montbretia. Activates the promoters of enzymes involved in the biosynthesis of the flavonol kaempferol and the flavonol-glycoside kaempferol-rhamnoside.
Subcellular Localization:
Nucleus.
Sequence:
MGRKPCCVREGLRTGAWTAQEDHVLVSYIKVHGDGKWRSLPKRAGLKRCGKSCRLRWLNYLRPGIKRGNISDDEEELIIRLHKLLGNRWSLIAGRLPGRTDNEIKNYWNTTLGKKVHGNASQTKPILNVSLADSTTAGTGAAGDASVVQTKAQRCTKTFFHQDQGLLPAPIDHQRHESTTAEPTSPSKAPQSDVSLDGVPLVPGEEDEAVCFSMSPNSTLLLDMPSMEDWIGSDCFQPDIDFSFTSVASFFDTEEWLNWT
The following text describes a protein:
Function:
Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.
Subcellular Localization:
Secreted.
Domain:
Contains at least one active inhibitory domain for trypsin (domain 6).
Sequence:
MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFINKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKDECSEFRNYIRNNELICPRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDSEMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESSTPGTTAASMPPSDE
The following text describes a protein:
Function:
Required for viability in the absence of the kinesin-related CIN8 mitotic motor. Seems to be involved in the assembly of alpha-tubulin.
Miscellaneous:
MISCELLANEOUS: Present with 2140 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTYEIGDRLKIGGYFCTIKFIGVIKPWPSVKAYGVEWDDHSRGKHSGTIDDIHYFDVQIPNSGSFLKESKIKSPGVRRITFYEALSEKYGGSSNNINDLSIGNKRVEGLGFDELNARNKNYKKLRKIALRDSDVAILFQNQDELNRVIQNCVNVKDLDLSLNLFTNINSLCEFIEPLKNLESLNISQNKLLSGWDNLKEYDLSHIKTLRLSSCGLSYKHIGKLLKSFRTLKMLDLSYNNLTSAGIQNFENEIPCTLEELNISGNNLISFPLFPKNLTLKGLNVSNNQISRAPSIAIYSVESLDITDNKFKERSLIDDLNKTFPSLKNIHLSGNEFNYNGNYINVEEQATFYEVLARFDRVMVLNGSICDVKTRREAEMFFVSKVMNNELSYDTNLPRWSSLIKSYEIDMSKLSFNNERETRQSLVLKIKIRAGKKPSSDLDYWVLPSFTVRYVKSVICRKLNFDILNVKLFHENSEGMINEIKYNFRPISDFNVVNGDIIHVSSPVNNKSIQKVNSPS
The following text describes a protein:
Function:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
Subcellular Localization:
Nucleus.
Sequence:
MSQARTTSKKPNQEPTPMETDPPKPPPTEAKYVSYTLLAAHDPQLKYNILKFAPSSNRKIEVDSFVQPIKLNRKDPWAIRKKAEEEKKRSTEAQEENASKTGENDNNDDENDNEMKVDQDNKASSTSTKQVRDDSVIGPAPASQPKKNQPFKKKTKQVFIAADQSARMLKKEEYQSWLLEDGSPNGERWVGRYESAGAAAGSSASASTSTSTNNDASNYVLFRMDPSGEAFQVIPCHRFYRFTQRPNYDTLGADEAEAAYEKMQKPTTKEDVGRWFMRRRGANPSSSGSSQPSKTLDNKTSGNVKHEGDVKPTSFFDHSKVSFGTSNKVRSQVEIPSFINGRRNKFTAVQGSNSRLDDDEDRKPNFGQEGDFDEVDYDEQFDDDEEGAGNLNDEAMEEDELKELAEKMKREMLAAGKAGDDEREKEDVDMAKDDLFGEREDLTKEGKAVKKLLMRKGEDNVYDSDDEVRNPYASEEDESDFEEVVPPPPNGPSPTDAKDPASRSGTPTPGSQPAGTSKSIATKGPVTQASNLKGDKPQSRPPSRSGTPSLPNHSRTNSASHPVHGHGFNAGPANRSRATSPQLPSSQLASSSAGPRSRAVSPVLSSSLKPSSPISANASTTNSNGKRKQHPNGAIASKEKKLNSGPTPPGRISSTISAAPDQESGVITKEQVVTLLKIRPLTTKELLAHFKQRLKEESNKVIIFAIIREIANIHEGLLVLKDGI
The following text describes a protein:
Function:
Plasma membrane magnesium transporter.
Miscellaneous:
MISCELLANEOUS: Present with 2130 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSLSTSFDSSSDLPRSKSVDNTAASMKTGKYPKLENYRQYSDAQPIRHEALALKVDETKDSRHKFSSSNGENSGVENGGYVEKTNISTSGRMDFEGEAEAEAVKRYQLRSFALLSSNARPSRLAKSETHQKQIHVESIAPSLPKNAALERGHDTALPAGTSSNRCNLEASSSARTFTSARKASLVSAIFETSAESEHGTHPKQAKLKRRTYSTISTHSSVNPTTLLTRTASQKSDMGNDTRRIKPLRMDSRVSFHSEISQASRDSQETEEDVCFPMFRLLHTRVNGVDFDELEEYAQISNAERNLSLANHQRHSERTYNHTDQDTGFTNSASTSGSSAALKYTPEISRTLEKNCSVNEMYVSENNESVREDDKPDLHPDVTFGRNKIEGEKEGNDSSYSRAYYTLQNTEYQIPSRFSFFRSESDETVHASDIPSLISEGQTFYELFKGGDPTWWLDCSCPTDDEMRCIAKTFGIHPLTAEDIRMQETREKVELFKSYYFVCFHTFENDKESENYLEPINVYIVVFRSGVLTFHFDPISHCANVRRRVRQLRDYVSVNSDWLCYALIDDITDSFAPVIQSIEYEADSIDDSVFMTRDMDFAAMLQRIGESRRKTMTLMRLLSGKADVIKMFAKRCQDETNGIGPVLKSQTNMVNLQAEQENVNQNNSNNQISLSNSYMQTTSQPRGDIALYLGDIQDHLLTMFQNLLAYEKIFSRSHANYLAQLQVESFNSNNKVTEMLGKVTMLGTMLVPLNVITGLFGMNVKVPGRNGSIAWWYGILGVLLLLAVISWFLASYWIKKIDPPATLNEAAGSGAKSVISSFLPKRDKRFNDDSKNGNARVGVRRKSTVSLPSRYSRYN
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDTIFTLPLSILALFQLLLTALHLTPGVNLTISQALRALTKNPASKAVVGTFGLVLGVLGTSSLVELYHGAEKVKQGSLRGEILATVDYLRVQVSCVLSLSNLLILLLNLALSAKACSLDRTEKNLTAMQRQVKGLQTEYERVTKADKAGAGAGAGTGSLAAEEAAALKKTLDRVIGEKEQLQAASEAAEKAAKAAEAKVTAMVSQIKGYDKEFDRMLDENKALKARLAQQAAAAGAGAQAGAAAAAAPVGPIPNKKDD