lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Sequence:
MSNEPKSKRGGSSENRGGGNVWLVLLAVTGAVVLSAFLFSDNRRRLAYPHLKELLAMSAERQEMLEAQRSASESGDAAANVDGESRPESSVISRSSSALISGDPANDIPVPKIVVPSSTKEDVWHEFSRLDNIFVADDRITGKVHFKSFVKNHPSEKEPAEEVTFLTIRGYPNDLIAAELEDLLVQSGVKWDNDRPSRFLENHWPELLMIGVLVALGIVMLKRMGGVGSPMSFSRSRGKLYSEDDLPTTFEDVAGIEEAVDEVREVVDFLKNSEKYQSLGGRIPKGVLLVGPPGTGKTLLAKAIAGEAGVPFFSLSGSDFVEMFVGVGAARVRDMFTQAVNRAPCIIFIDELDALGKSRSGSVVGGHDEREQTLNALLVEMDGFDSNSGVIVVAATNRPETLDPALLRPGRFDRHVLVDRPDVAGREEILAVHVKNVKLDETVELKGIASITSGFVGADLANLVNEAALLAARNGKPAVAMEEFNEAVERVTAGLEKKNRVMNEDEKIRVAYHESGHALVAAALPNTDPVHKVSIIPRGLAALGYMMQRPESERFLMTKSELESQMKVMLAGTLAEEMIFQDISTGAQNDLERCTETARSMVMDYGMSRLGRINLRRNTRSPFLAGSGGGEYQIMHSDEMAKMIDKEVSRIVDDMLVHTREILEQRRDVLEAVTQRLLEVEAIDSDELMRLIQENSRGPWLVPGTVTEKPKAKIVPREETESQQSNRS
The following text describes a protein:
Function:
Active in protein import into the nucleus. Its major import substrate is transcription elongation factor TFIIS.
Miscellaneous:
MISCELLANEOUS: Present with 13500 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MDITELLQCFACTLDHNAAVRTNAETHLKNASKVPGFLGACLDIIAADEVPENIKLSASLYFKNKITYGWSAGARQGSNELLDSHVDPDEKPVVKDMLIKTMVSVSKTSPRCIRVLKSALTVIISEDYPSKKWGNLLPNSLELLANEDITVTYVGLLCLAEIFRTYRWKNNDERQDLEELILNYFPALLNYGANVLFQDGKYMNNEQIGELVKLIIKIYKFVSYHDLPFTLQRSESFTPWACFFVSIIQQPLPQEVLAISDIEVRSKNPWVKCKKWALANLYRLFQRYASTSLTRKFQYDEFKQMYCEEFLTQFLQVVFDQIEKWGTGQLWLSDECLYYILNFVEQCVVQKTTWKLVGPHYNVILQHVIFPLLKPTAETLEAFDNDPQEYINRNMDFWDVGYSPDLAALALLTTCVTKRGKTTLQPTLEFMVSTLQSAVGDYNNIMLDNALQIESCLRIFSSIIDRLITKDSPFASEMEKFILTYVLPFFKSQYGFLQSRVCDICSKLGSMDFKDPVITSTIYEGVMNCLNNSSNSLPVELTAALALQTFISDDQFNMKLSEHVVPTMQKLLSLSNDFESDVISGVMQDFVEQFAEQLQPFGVELMNTLVQQFLKLAIDLHETSNLDPDSFTNVDSIPDESDKQMAALGILSTTISILLSFENSPEILKNLEQSFYPAAEFILKNDIEDFYRECCEFVENSTFLLRDITPISWKILELIGECNRKPDSMVSYYLSDFMLALNNILIYGRNELKKNEFYTKIIFEIYQKAVTAEDNSLDDLRVVFDLSQELVLALDDSLPQQYRERLLADVVGSILTQKNELKTNVVFSVTAFNVVISNMITEPLITLQYLKQQGCLEIFFQTWITDYIPNYKRCYDIKLSVLALLKIILKLESNDYSVLNLENLVPQLGSIVTQLASRLPTALRQLANQRKEFSSSGFEEDTKWDENFLDVGDDDENDDEGDLTEKYLELIKNRADSLDFVDGYDAKETFDDLEEDPLTGSILDTVDVYKVFKESIANLQHVDSNRYQGILRHLTPADQELFMGIMNA
The following text describes a protein:
Function:
Required for defense response to Xanthomonas campestris pv. vesicatoria (Xcv). In heterologous systems, confers resistance to bacterial pathogens such as Pseudomonas syringae pv. tomato but susceptibility to pathogenic oomycetes such as Hylaloperonospora parasitica when expressed in Arabidopsis thaliana. May be involved in the regulation of responses to bitoic and abiotic stresses.
Miscellaneous:
MISCELLANEOUS: Susceptibility to X.campestris pv. vesicatoria is enhanced upon virus induced gene silencing (VIGS).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTPPPTSTVPPYVSLIVRILTLICLLISFIVIATNNQTVSTVAGDVKIKFKDFYAYRYLIATVIIGMAYTLLQIAFSISLLTTGNRIGGEGFLLFDFYGDKFISYFLVTGAAASFGMTQDLKQLEGSDNYSKFLNTSNAAASLCLIGFFFAVASSIFSSYNLPKRI
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
AQQIENREQTIGDLVTALGPHLTNKDTKIRIDACTLLSNVIHKLPKDCLNQGELESLVQFLCSRLEDHYTLQPVALSLLLQLSSADNLTGENACSIITSVFKEVHIQTCMQHDRLKIFQILGTLLDIHTKDVITMGRDFLYQYIQVIDGEQDPRNLLTIFQLTKNLIESSFPLFDLVEELFDVSSCYFPIDFNPAAAGKKSTITNLDLVSSLRGVLASTKQFAQYCIPLMLEKLESDVESAKIDSLETLTACLGCYGKQELEKYLSSLWSDVKREINQSSSEQIEKCCLTFLTSLLSNLSSWPVDQKSEKATDLKSFLDDVLEDCVPRLQAQSDDRSKWMAGHVVLACAKSSKKACSQIVTTVLPILLQNAQSKSASTTLAGQSVQQSALDNLVKLTAVCGQFNFENHPVLKKKEEFFTILNELALKSEIEEQLKCIAVAGFASLLKLEILSNVELTEIASLLLKMIKLKPESHLRGEVLSVAGYLSSQHPDVAKSHLIPCVMRRMEEGDDSCFDVLASVCTHFDVLKLVLGFIMERIVNTQVDETSEPLLHACLESLQKMTSSSWVGNTEIEYMALNLVLPLLKRCIEVTLELSVPEQCCANCHIFEDVSKSAAIVIRNVCQKLKPGKSTDLVIQLIASLYNNSKLSSLDIKSDVHFTPFHPKASPLQTRTLCFLPATICALHPNIEIPELAELETKLLNTCLHCTDQPSYVFAAKALSGLVNKYKKPSIPILEKLKSHFDTDPNWSLKSEEEKMMILTLLIWICKALVLSNHPDSLIFIKNLLYWMGDDSVGEVAAAGFDIILRESNEVLSPSSHSTIRLMHKQRFFLLIIPEIVSSFKTSENKTQQTNILTALSHLIGHLPKQVLMQHFTELLPLLTQALHTDNTQLLKSVLSTLFCFIQDTTEAMTAHLENLMKHFLRLSKFKQDIDVRVKAVQCIGVVTLLPPIVILPFKNDIVRHLVSVLDDRKRDVRTEASKARSEWFLVGT
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MRFNNKFDLNLLVALDHLLHLRSVSGAAARMNVTQSAMSNALLRLRNYFDDELLVKIGRKMELTPRAEALKDSIRDLLVRVDWTIASTSEFDPAQSDRCFKILASDYTMATLVPALLARCEAAAPGIRFDFLQQVQAPERALERGDVDLLIIPREFSSKLHPSEVIVEEDFCAIAWSKGKFARGKLSRSDYTKASHVVMRPAIATQSLETRYLEQGGVTRNEAISTYAFTAIPHLVVGTNRIATLHRRLAKLAQRSLPIRIIELPVSLPIMQQCVQWHRYRSNDAGLIWLRDTMRAAALELR
The following text describes a protein:
Function:
Has actin-binding and actin-bundling activity and is a component of the actin patch. Stabilizes actin filaments against disassembly. Cross-links F-actin and is required for the formation of the contractile F-actin ring.
Subcellular Localization:
Cytoplasm. Note=Localizes to the barrier septum.
Sequence:
MTSQLEKEAREWIEETLHTKLNAQLDLLDQLQSGVILCRICKEALGANIRYKESNMPFVQMENISAFINYAQQVVHVPSQDMFQTSDLFERRNDEQVLRSIHSFSRYAAKMFPGKVRGLGPKLAEKKPRVFSAQQQREFREGVNSLQYGSFDMPTQGTEKIAFSRRRDPTGNMY
The following text describes a protein:
Function:
Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
Subcellular Localization:
Secreted.
Sequence:
MLACLPVGAAIKAAPYRQHRYFPPCFTWTETRLSMSVALRAQLLLFLISLSSRMGLTRYIEDSDAADGIYSLLSFAQKRESEDFIFRRPLRCLDMLATEGYFTFVASRPQLACAAFVIAEPNEVISLELSDVNIDCSAGDFIKIFDGWVLKGEKFPSSHDHPLPPHERYTDYCSSMAPGLSSRSSQNVAMIFFRIHSPDSGFTLAVKKMHNPMPCNIMSQSPEGSFTMVIPHQRTNCSFSVIYPVEIRLTELSLGEAKSNEIRPLRQMWSGCSGSGDYVELLGGNGVDTSKMIPVADLCFSPSGLAQMKIGCDNSVVRLVSSGNYINRVSFQYRLLDQNELPKTRENSLEDFCRME
The following text describes a protein:
Function:
Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Required for vulval morphogenesis and zygotic cytokinesis, suggesting that glycosaminoglycans play a central role in vulval morphogenesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MLFNGTTKYRDYAIVISLFFLLNVYLLYNTAQHTQVGNSKHISSDSGEKTSNPLPSCEITDDLAKSAISRAITPSCKAKLQLEACQLKNGTFTINFPENQCPNHDSRLIDQRIGCFLDKKEARVLTEFEYKLPKSNGKATCRKHCYKAGFLYFGLEFGHECFCGNDVSNATAVDDVECRAYKCPGNENSEEFCGGFNAVEIFRTGFRSKVNHRKPTYLPPSSDSIKNPVKILFLLQLNGRNERQVKRFLKSIYLPHHYYYIHVDARQNYMFSEMQKVADFLDNIHITERRFSTIWGGASLLQMFLQVIRDSMKIEKFKDWDYIINFSESDFPILPISDFERLITVNNGKSFLASHGYNTGKFIQKQGFEYVFSECDNRMFRIGKREFPQNLRIDGGSDWVGIHRNLAEFSISDEELPRKLRKTYESILLPLESFYHTLAFNSEFCDDLLMSNLRLTNWYRKQGCRCASLKPIVDWCGCSPLVFREETMKKFELQKAISKPTYFARKFDSMVDIDSIEAAEMQSISPEKLQLNHPTYHFAFANIFKTGIDEQKLHFESLANFALKSTETRAKFRKVLRIDALRAHHNALIEIVMKIETTDGATFEFLIHRLSHVNLTENEEKLVEHGYLLRAVSFGTKFEWKEELCREYMGFVTDNDTLHTRLQWHPTEHVKKVGDKTSPEMIFKYRKGDELIEQTVVKPYDSVFGGQFDSWNVGKKLSNLTTCSNFFVDIISPSSPDDAPPLATLHFPVYTDQNAHCHVDYLRQFFKIADFCTSGDACKEKIWSTSYPDPKSDIFVGYDEDTQTLI
The following text describes a protein:
Function:
Microtubule-binding protein which regulates microtubule organization and stability. Promotes the stability of astral microtubules and facilitates the proper orientation of the mitotic spindle. This allows the oriented division of basal keratinocytes and contributes to epidermal stratification (By similarity). Required for the assembly of both primary and motile cilia. Destabilizes the interaction between CCP110 and CEP97 by competing with CEP97 for binding to CCP110 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, cilium axoneme. Note=Localized at the centrosome and accumulates at the parental centrioles during centriole duplication in cycling cells. In ciliated cells, detected at the basal body of the cilium. Localizes to the centrosome during interphase, to the primary cilium at G0, to the spindle poles during mitosis and to the centrosomes and central spindle during telophase and cytokinesis.
Sequence:
MCEGPSRISGPIPPDPTLCPDNYRRPTSAQGRLEGNALKLDLLTSDRALDTTAPRGPCIGPGAGEILERGQRGVGDVLLQLEGISLGPGASLKRKDPKDHEKENLRRIREIQKRFREQERSREQGQPRPLKALWRSPKYDKVESRVKAQLQEPGPASGTESAHFLRAHSRCGPGLPPPHVSSPQPTPPGPEAKEPGLGVDFIRHNARAAKRAPRRHSCSLQVLAQVLEQQRQAQEHYNATQKGHVPHYLLERRDLWRREAEARKQSQPDPAMPPGHTRMPENQRLETLTKLLQSQSQLLRELVLLPAGADSLRAQSHRAELDRKLVQVEEAIKIFSRPKVFVKMDD
The following text describes a protein:
Function:
Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
Subcellular Localization:
Cytoplasm.
Sequence:
MDVTGQAATKEVSKIVNDEVSSIEIKVLLFARARELTGVPDLTLKMPSGSTTKKCMDELVIKFPKLEEVRSCVVLALNEEYTTDSAIVKHRDELAIIPPISGG
The following text describes a protein:
Function:
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Subcellular Localization:
Cytoplasm.
Sequence:
MKTKVELKFLGGLESYLANKSKNYVSLEIESEEFNFENLIAYIRNHIIVDRKDVFSDFVMSDGNVKSCNVMIDDKEYSNYNLSDKGKIKPGIIVLINEYDWEILDTYTYKIKNNDKICFLSTLHGG
The following text describes a protein:
Function:
Microtubule-associated protein that may be involved in cross-linking microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MLCPPDVAFEKRHFKRRDGNKVVPPSIALVAGLESGFLFKLSAVEDVARRGQFPGLLTEDGFLLMCEESEHIRDAYAMAKHLVALAPDGIFTRATLQEAAGKVGSTQDTLSVEEVDALFNALDSDNRGYVSVDEFMDALYGEEGREAMREIRREYMRRKIEVEGEPSWRMRPTPKPTRKLRQKRKREQGQKRKQGQRQKQEQGQRQKREQGQRQKQEQGQKRKRERGGAQRPPPPKQKAGCGC
The following text describes a protein:
Function:
Deubiquitinating enzyme involved in telomere and HM loci silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes. Targets histone H2B for deubiquitination, thus helping to localize SIR2 to the telomere. At silent chromatin, including telomeres and the rDNA locus, not only maintains low H2B 'Lys-123' ubiquitination (H2BK123Ub), but also low H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). Controls the proliferating-cell nuclear antigen PCNA/POL30 deubiquitination which is crucial for keeping TLS polymerases in check as well as for down-regulating the error-free bypass. Deubiquitinates and stabilizes RPA190, the largest subunit of RNA polymerase I, to achieve optimal levels of ribosomes and cell growth. Also protects nutrient transporters such as GAP1 from ubiquitin-dependent endocytosis.
Subcellular Localization:
Nucleus. Chromosome, telomere. Nucleus, nucleolus. Note=Preferentially localizes to silent chromatin.
Domain:
Residues 2-27 within the N-terminal intrinsically disordered regions (IDR) constitute the binding module for DHR2 which is required to coordinate the UBP10-DHR2 interaction; Residues 109-145 within the N-terminal intrinsically disordered regions (IDR) constitute the binding module for SIR4 which required to coordinate the UBP10-SIR4 interaction, but also to direct UBP10's functional role in telomere chromatin silencing; Residues 167-208 within the N-terminal intrinsically disordered regions (IDR) constitute the binding module for UTP22 which is required to coordinate the UBP10-UTP22 interaction.
Sequence:
MTTQESIKPLVDRILSNPLQFNAAMISNKSNNNDTSAAPENSSYIVIGKQHNNNSNSTAIAATAESKQIKENNLIDRPNGKKTNTVPKSMAEALLLYTSKNDKDAADATGAKKSAELSTELSTEPPSSSSEDDKVGKEEEEEGEIFHEARDYVEPRKASLKERDNADKGDGEDIGEDIGEDIGEDIGEDIGEDIGENLGSPLATIDDSSNENEKEKRKELSTSISSDDEIEDDEDEDDMDYDSSAMEKELPEEEENDSSSKISEGEKKSLYQDLMENSTVEVNRYEPVNNTKENGNRNPKGEEEEEEEEELKHKSRSITPPVTISNLSNFYQFNENINDRGSLNSTRIVKNWGDKFTNLKPRGLLNHGVTCYTNAAVQAMLHIPSIQHYLFDILMGKYDSTISKNSVSYTLAETSKKMWLPVSKNPRKNVSASYINPKHLISRLDDINCMMSEWQQEDSHEYFMSLMSRLQEDSVPKGHKLIESIIYDIFGGLLKQIVTCKSCGSISKTEQPFYDLSLHLKGKKKLDPNSDLSSDSINGTSATTSTTTSNAATKPSLSSSSSVNLNNGSPFAAASDLSSANRRFSIEKSIKDFFNPELIKVDKEQKGYVCEKCHKTTNAVKHSSILRAPETLLVHLKKFRFNGTSSSKMKQAVSYPMFLDLTEYCESKELPVKYQLLSVVVHEGRSLSSGHYIAHCKQPDGSWATYDDEYINIISERDVLKEPNAYYLLYTRLTPKSVPLPLAKSAMATGNVTSKSKQEQAVNEPNNRPLKINSKKNNRKKWKKNKKRKFTK
The following text describes a protein:
Function:
G-protein coupled receptor for the neuropeptide like protein nlp-38. Plays a role in several types of aversive gustatory associative learning including gustatory plasticity and salt avoidance learning. Its role in salt avoidance learning may be through activation of the transcription factor crh-1/CREB and de novo transcription and translation, which in turn promotes the formation of long-term memory.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNYEVYCGNAHAEPNSSAVQQLAEACVEQDASYFDGCSRTCVKDKYLLPLTQFDNLEIVVYGQIFPILVLFAVFANAAVALVLSKKHMITPTNVVLKYMAIAELLVGLVPLPWTLFFFSMGNIKETHRLELWWCYLQKYSMDAFPPVFHMIAMWLTVLLAAQRYVSISHPLHSRSACNVKNVRLATMIITVTSFLCGLPKSFDYEYETVHGWIYSHGNWTYASSCVMMPTAILTNMGQTVYFNIYFWTRALGFIILPSFLLVLLNGLLIKGIRRAQRRKLRLLREKRSEEAARQRDSNSTSLMLVAIVSIFLIVNLPQAIFMGLLCVCETFTIKIPILEGTFPAVFLIASNMIVIATYPINFGIYCFMSSSFRQTFKLLFCPGASQLQCERRIEAASAVHSSRRRSDICSHLVNVCTNSEGFMQVSHHCLHVDYLVSDRQSTQFTTMDRSD
The following text describes a protein:
Function:
ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MLSLAAKLVAFFWRTADTPREEAGRLEPELAEGDTKLKTVRGVVTRYCSDYGMIDDLIYFSSDAVTSRVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWEDDSRNHGSPSDCSPRVLIGCVTSLVEGAGCISQTTYFSLESVCEGFEPCKGDWVEAEYWIRPGTWSSEATSVKPLRYKRVDKVCISSLCGRNGVLEESIFFTLDSLKLPDGYTPRRGDVVNAVVVESSQSCYVWRALCMTLVKRRDAAPVHEATHFYGTILLKNKGDIEVTQMTHFGTLKEGRSKTMVIWIENKGDIPQNLVSCKLAGWDKSKQFRFQMLDKDQMCPVVSFVSVPEKENSSDENINSLNSHTKNKTSQMSESSLVNNRGISPGDCTCKGENGEKDNILSRKQMTEPEPGGLVPPGGKTFIVVICDGKNPGRCKELLLLCFSDFLIGRYLEVNVISGEESLIAAREPFSWKKLKSSQALTSAKTTVVVTAQKRNSRRQLPSFLPQYPIPDRLRKCVEQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIYAEMELKEYNMSGIILRRNGDLLVLEVPGLAEGRPSLYTGDKLILKTQEYNGHAIEYISYVTEIHEEDVTLKINPEFEQAYNFEPMDVEFTYNSRRCHFALEHVIHLEEIILQSPQVREIGTMHKHQKQLDKSTSKKNRKTMTDQAEHGTEERRVGDKDLPVLAPFTAEMSDWVDEIQTPKARKMEFFNPVLNENQKLAVKRILSGDCRPLPYILFGPPGTGKTVTIIEAVLQVHFALPDSRILVCAPSNSAADLVCLRLHESKVLRPAAMVRVNATCRLEEIVIDAIKPYCRDGEDIWKASRFRIIITTCSSSGLFYQIGVRVGHFTHVFVDEAGQASEPECLIPLGLMSDISSQIVLAGDPMQLGPVIKSRLAMAYGLNVSLLERLMSRPAYQRDENAFGACGAHNPLLVTKLVKNYRSHEALLTLPSRLFYHRELEVCADPTVVTSLLGWEKLPKKGFPLIFHGVRGSEAREGKSPSWFNPAEAVQVLRYCCLLAQSISSQVSASDIGVITPYRKQVEKIRILLRNVDLMDIKVGSVEEFQGQEYLVIIISTVRSNEDGFEDDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSITNGVYMGCDLPPELQSLQNCGEGVADPSYPVVPESTGPEKHQEPS
The following text describes a protein:
Function:
Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Is also significantly active with galactose as substrate, but not with mannose or glucose 6-phosphate. Can utilize both NAD(+) and NADP(+) as electron acceptor, with a marked preference for NADP(+). Physiologically, may be involved in the degradation of both glucose and galactose through a non-phosphorylative variant of the Entner-Doudoroff pathway.
Sequence:
MTEQKAIVTDAPKGGVKYTTIDMPEPEHYDAKLSPVYIGICGTDRGEVAGALSFTYNPEGENFLVLGHEALLRVDDARDNGYIKKGDLVVPLVRRPGKCINCRIGRQDNCSIGDPDKHEAGITGLHGFMRDVIYDDIEYLVKVEDPELGRIAVLTEPLKNVMKAFEVFDVVSKRSIFFGDDSTLIGKRMVIIGSGSEAFLYSFAGVDRGFDVTMVNRHDETENKLKIMDEFGVKFANYLKDMPEKIDLLVDTSGDPTTTFKFLRKVNNNGVVILFGTNGKAPGYPVDGEDIDYIVERNITIAGSVDAAKIHYVQALQSLSNWNRRHPDAMKSIITYEAKPSETNIFFQKPHGEIKTVIKWQ
The following text describes a protein:
Function:
Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics (By similarity).
Subcellular Localization:
Cytoplasm. Note=Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells (By similarity).
Sequence:
MSSSEEADLLRLEEVFSTTLARTISLILQPLLLADPEPSDPCGKECLRLLQQLHESAQRLWYVTEQSLLSLRQRLYHPPSKGLEAVLLLSNADHVLQAHMEYIKSYTDCVVAQAFQKVSKKRSEFWRSQRKALRQLLSSGSSEGSVGTTMCQALRQPLSQHVQKYLLLLLSLRDTLDESHPAQELVMHAITLFGNLQSFMGQALDQAVATQALWHSLSSRLRDVLCSPAHRLLQDSQDIPVVVTPLRAERVLLFDDSLVLLQGHNTHTFDLKLVWVKPGQDKCVLHILTPEEEISFCTRDPQGQVVWQWKVTQAVCQALCGKKDFPVLGSGRETSVPPECRCVAYTFCREGRLCQATYDGEWCRAKPHGKGTLKWPDGRNHVGTFYQGLEHGFGICLVPQASEDKFDCYKCHWREGRMCEYGICEYGTDEVYKGYFQAGLRHGFGILESAPQAPQPFRYTGHWERGQRSGYGIEEDRDRGERYIGMWQADQRHGPGVVVTQAGVCYQGTFQGDKMAGPGILLCEDDSLYEGTFTRDLTLLGKGKVTFPNGFTLDGSFSSGTDKGLYTQGVLDTAALPPDPSSTRKRQLGLGTFPVESRWQGVYSPFRDFLRLGCPGEQQEALLGFHTQSSRELRKSQECLCCERSHPEDCVGSMEDTLKELLQHRKPKALQQYLRKALSNSRHPLGQLLRTLMLTFQATYSGIGANKHLQEMAQEEVKQHARELWAAYRGLLKVALQHQGQTLEEENMETRDLQVHGLLLPLILPSFYSELFTLYLLLHEREDGLYSRGITNLSLFPDTKLLEFLDVQKHLWPLKDLKLTSNQRYSLVRDKCFLTATECLQKIITTVHPREKLEVLEKTYGEIEATVSRVLGCKYKLPMDDLLPLLIYVVSRARIQHLGAEIHLIRDMMDPVHTGGLHDFLLTALESCYEHIQKEDMRPHHLPGHWDARDLW
The following text describes a protein:
Function:
Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (By similarity). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function (By similarity). Required for normal hearing.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, filopodium. Apical cell membrane. Cell projection, stereocilium. Cell projection, stereocilium membrane.
Sequence:
MAFPDITEDDLNELMREEAEDVFDDDGVSSRFPDIMAAGTHSPGGPNGIIRSQSFAGFSTLQERRSRCNSFMGNSAVQKKPISKPRKPHLSGHKSSSSSSSSREPQPKRVEEVYSALKQGLDEYLEVHQTELDKLTSLMKDMKRNSRLGVLYDLDKQIKTIERYMRRLEFHISKVDELYEGFCIQRRLRDGASKMKQAFTASPSTKGTRESLAEVNRRYKEYTENMSTFEGELENLLGEFHIKMKGLAGFARLCPGDQYEIFMRYGRQRWKLKGKIEGNSKQSWDGEEMIFMPLISDLINIKVTELKGLATHVLVGSVICETKDLFTAMPQVVAVDVNDLGTIKLNLEVAWFPFDVEDLTLSSGNVSKATALQRRVSVYSQGTPETPTFQDTSFFKWQPRRWEGQRLSFLHTLRETLIEKLRRSRSFGDLAALRPRSRSSLEVYSTLPDDVFENGGCGVAECKRLSFTFSDTSTSSPVPVQSNPEITVTPPETDPSSEPPPTSEEQLVEEECVEEDCGSISVSVSVSDPDLEWDQVETQGPETGSVALSLCSESQLSAVGPEDVVFLEPNVSDEALELKPVELDGEEGSLTRQLVRRLTSSDMLPETSALSWAGENSRTFMESSLEEVIQSLLLRLESLGQRCGELQDLEQEVMRLEDLLKCRVHAHRSRSSSLSLTVESALESFDFLNTSDFDDDDTGDDAGTLSRAVFFDMESERMGSGQHPEARGHLSEALTEDTGVGNSVAGSPLPLTTGNENLDVAVVIHLQYCNHLIQLLTSGGSQLQHKTYLHKLATQTLLLEELSERNFDRPSSCTSVPDVLPGLVERPALMSLWSDCSGGLFHTTLDRVLKHMHLSFALGLQQVLPHSPDSVIKMVVNEMMDRSELASSSTSPAQDVITVFQFHRYIVEHCITDMEQHLLDLAKEVMLEEALSCGDPERSLKELKKVSITCLQPRSQTLLAVAGLLTTDDPEVMKATTDFLSSAASHQPFRSKAVDCYTQALSESELHTQRAACAALSCLQAVESIDAVILLCDSVDEELRQIAIETLLTFGEDGRLAYEQLDTVPREMVRLGTRRGNAVTTSF
The following text describes a protein:
Function:
Transcriptional repressor that binds to the motif 5'-(C/T)A(C/A)G-3' in the promoter of target genes. Also binds to the 5'-CTTGNNNNNCAAG-3' consensus sequence in chromatin. Can bind to the mitochondrial dysfunction motif (MDM) present in the upstream regions of mitochondrial dysfunction stimulon (MDS) genes involved in mitochondrial retrograde regulation (MRR). Together with NAC050 and JMJ14, regulates gene expression and flowering time by associating with the histone demethylase JMJ14, probably by the promotion of RNA-mediated gene silencing. Regulates siRNA-dependent post-transcriptional gene silencing (PTGS) through SGS3 expression modulation. Required during pollen development.
Subcellular Localization:
Nucleus.
Domain:
The NAC domain includes a DNA binding domain and a dimerization domain.
Sequence:
MGRESVAVVTAPPSATAPGTASVATSLAPGFRFHPTDEELVSYYLKRKVLGQPVRFDAIGEVDIYKHEPWDLAVFSRLKTRDQEWYFYSALDKKYGNGARMNRATNRGYWKATGKDREIRRDILLLGMKKTLVFHSGRAPDGLRTNWVMHEYRLVEYETEKNGNLVQDAYVLCRVFHKNNIGPPSGNRYAPFMEEEWADDEGALIPGIDVKLRLEPPPVANGNDQMDQEIQSASKSLININEPPRETAPLDIESDQQNHHENDLKPEEHNNNNNYDENEETLKREQMEEEERPPRPVCVLNKEAPLPLLQYKRRRQSESNNNSSRNTQDHCSSTTTTVDNTTTLISSSAAATNTAISALLEFSLMGISDKKEKPQQPLRPHKEPLPPQTPLASPEEKVNDLQKEIHQMSVERETFKLEMMSAEAMISILQSRIDALRQENEELKKNNANGQ
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGRTRPKKLTSKASIPIVREHEIDIIDDEVQNALQQVETGVEKAEESEFHLQAAISATAQGKVNEAHIPTPETVLSNLRYDELYPPIFSQPATYIRFSSTIEDCCGCPYNMTEEDDVFFKIMNEKREPSNRITEDQFEEVMYFFEETAQTKQPFAAVDSPPVLSFAEMQDSMDATVEESVKCFAKDIYEHWKLRRIATGNRPLLPSLKFETGQDTDDTDPYVCFRRREVRQIRKTRGRDAQSADKLRRLRKELEDARQLVALVRQRELARKEMLSMERQIFLQRSEVKEMKRKLNIKDDDEDLINQKVTSIPARLPHAFANLPEQPKKKPAEAPAAQRPTAPQIRMPQKPGTQAADDMQLLEDVQAEKENEILRDIKQNIAKHIKWNEGYVDYTRAPLSPPPEKTFQAAFRPAITTQLPTPPSSDSSDNMMLESALDTANSLSFRDKLVPRTWEMNEDTCRIPSFRRRIGRGGRLMIDRRNMASRCRIEMDPLKADRFKYDREDSDDESEFECDPYDVQIMQHRAIMAAKARDQAAAAAQAHAQAQAQKRLQAEQTTTNNGPPNIGHTMGSNPGPGAVASTS