lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Recruits the histone methyltransferase dot-1.1 to chromatin to methylate 'Lys-79' of histone H3 and activate transcription. Recognizes and binds histone H3 methylated at 'Lys-4' (H3K4me) at the promoters of target genes. During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes. In response to stress, binds to the pdk-1 promoter to negatively regulate pdk-1 expression, which negatively modulates daf-16/FOXO-mediated gene expression. Thus, most likely via this mechanism, in response to stress, it confers a protective role against neuronal necrosis. Plays a role in Insulin/IGF-1-like signaling (IIS)- and diet restriction-mediated lifespan extension by controlling daf-16/FOXO and pha-4/FOXA recruitment to target promoters. May negatively regulate the expression of genes required for vulval development. May play a role in axon guidance in D-type motor neurons. May suppress sensitivity to RNAi; [Isoform a]: Required for migration of HSN motor neurons during embryogenesis.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to all six condensed chromosomes. zfp-1 and dot-1.1 colocalize to promoters of highly expressed genes.
Domain:
The PHD-type zinc finger 1 most likely mediates nuclear localization; The ePHD2 domain folds as an integrated structural module comprizing the C2HC pre-PHD-type 2 zinc finger and the PHD-type 2 zinc finger. It mediates non-specific binding to dsDNA, but does not bind histones in contrast to many PHD-type zinc fingers.
Sequence:
MKEMVGGCCVCADENGWTDNPLIYCDGENCEVAVHQGCYGIQEVPEGEWFCAKCTKASAMMPGSINEATFCCQLCPFDYGALKKTDRNGWAHVICALYIPEVRFGNVHSMEPVILNDVPTDKFNKLCYICNEERPNDAKKGACMSCNKSTCKRSFHVTCAQRKGLLCEEGAISRNVKYCGYCENHLKKAINDPAIKVIPACPPVQRLSKEQDKKKTVLLTSLPLPPPAPRLHMLADPLPIKSNKVNNVLGLGSAINAVSLEERPASGSTVNSGIFVPPPTAFSPPLTTSSRSSVAQDPSPPLTINKNSLSSSGPLIPSTAHLSATTASATPIMANGSTLPPSSETTVGTHCLQQLQIQSAAAAAITQNQIGPSELNGYPAASQLSSFMHEIPARNTTSVASLLPPGAAEYHLNGSGDEEKTVKAVLTAPLTKAKRIRDSKNDMMDKTHKRPRANARPPAVLGSMSSGSSGGTVGKSPSMQRLQNLVAPIVSETVTDFQRDRVADRTAAERRAAAAQSQPSTSTNGGPNVTIPAVVEVHTNSTNSTNHQNNGLTQNAPASTSMQAGTSSNDGVISQNGTSSTSQSNRLNLPSFMEQLLERQWDQGSSLLMANAHFDVAQLLSCLFQLKSENFRLEENLSGLRKRRDHLFALNSRLAEVNTLDVSKRQRSDGLLLQQQIAHHLDPTSIVPKAEVHKQEPLSAPTSVPLPANHSSSLFEDIKAPKATYSRKTPSNIPLTVPLSTAATALTTTTAASSGAPVNSNIQNHRATPSTAGAPMAATPIMTAVTSANELAALSPERAQALLNMYRMPLDANVAAQLSMITNFPGQVNPSLFSRLLAVNMMNGGLQPNGQPLSALPPPTSATPNGK
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MEKNDDKDPDLHHDDDHNDKSKEEEKGDTVSDDVDVDKKENVDVSNAETDHVDPGDNADKVNSPLGQEEAPPEIPQTIESLSEELDQLLTSLSLHKEEHKDVTEEEKGEDGNYFQIPQFVGKFLDLFEDKLSKHDTVDPKTTWYQDPEEVSSLLEAVDRVSKLMELLLNTKSCLDHHESLINHAGSIQQRAMALFEDEFRVLLEESVIKEPAVVTEDQQDHHNDSQDQDNVNNVPEGGDEKIEYPGYSEEMVVLLRKIVERMKGAGYGCECKEAYLVGRRNILMRTLKQECEFEKVSIDEVQKMSWGELEREIPIWNKTVKDCSSLFFPGELKLAEKIFPGDEGSLFNIVTHGLAIQFLGFAEAVAMTRRSTEKLFKILDIYETLRDGFPAIEELFTEELRSELRSEVTSARSRLGETAINIFSDLENSIKSDSSKTPVPGGAVHPLTRYTMNYLKYSCEYKGTLEQVFKSHSKMEEEESTERAFANQLMRIMDLLDGNMEAKSKLYKDIPLSCIFMMNNGRYIVQKIKGSAEIHEVMGDTWCRKRSSELRTYHKNYQRETWGKLLGFLGHEGLMHNNKIVKPNLKERFKSFNATFDEIHKTQTTWVVNDEQLQSELRVSITAVMIPAYRAFMARFGQYLDPGRQTEKYVKYQPEDIEDLIDQLFEGNTSSSSTATAKRRT
The following text describes a protein:
Function:
Activates the expression of the CowN protein in response to carbon monoxide (CO). Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO).
Domain:
The N-terminal sensor (heme-containing) domain is covalently linked to the C-terminal, DNA-binding response domain.
Sequence:
MDDFAYNLRRAETGVLLLADDLTVTAVSPGALSLLGLDKPGALLGRPILDLHPPPLRPKVAVLLKTARGPSGPAATAVLSLRGGPVLIRASALTGQGETAFALVLTAVGESRETKEGPSARPAPPGYLRKVPLGLGETTEFVDTAGVIYLEADGHYSRVHTAFGHSFCPLALAELERRLDPDQFLRVHRSYIVALAHVRAFRKRESGGLLVMDTGAGDLVPIGRAQVTRLRGLLAI
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MKVGGSHRMSCGGSKKAAEVEEELQLEEDKAETVDSPSGRLDSLDEGDASGSQCQLDLQEDQPAQSPGPQGQREGKAPKRLKEKCVGQVERSGVCTECGKKTWSGPGRGYSVPTSERPHQCPTCGRCFRQRSILAKHQKIHTGEKPYLCIACGKRFNRSSNLAQHQRVHTGERPFPCLDCGKAFTQKSDLERHQRVHTGERPYACQDCGKSFSVSSHLDRHRRTHQHSHLEEPPAASLAPVIAHCCPDCGKCFGQRAALSKHCKTHSGERPYPCDACGKRFSRSSNLAQHQRIHTGERPFPCSDCGKRFIQRSDLERHQRIHTGERPYTCAQCGRGFSVSSHLDRHQRVHQAQAAAAAAHRCPEHIKGFLLSTGGKQVLKHQLYSGKGRLTRSGYCLDCGKSLGKIPLQLVAPPVEKPFKCDSCGKAFAQRSALGKHQRIHTGEKPFSCTDCGKAFIQKSDLTIHRRMHTGEKPYRCDTCGKCFSVSSNLLTHQRTHLGEKPYACGECGKAFIQRSELTIHQRTHTGEKPYKCSVCGKCFSRSSHLNRHQRTHGNDKSVIGSEAAPTALLSTHTTKPASSLPASAFSVSFTSPSPLPTLPSFPSSPSSLHIPSLDLPWSLPFPSRSFSHSVFQSVPSGVQTSLIN
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MEPEQKVSTRMVLLALLEDIEIVSKELLEYMGSSRQTKQDDMDPTQLINLLKQKDIEFQECMRTAREQGEIQKEIDELRLEVDRRDAYIRQLQKNLKEAEELLLTMTYEAKLKLKSIQQANGRKISSEELIKYAHKISASNSVACPSSWAPGDPRRPYPTEVDMRQGLLYTDYNNKMIPGLSQFNDRQLGGQYQQMGGANNMGAVGSGSLTWQPSAEVQSTLLNRLPSSVEPTTPNSGSNTANNMRMLRDYSTPQQQIVLQQQQQLQQQQQHDQNNKDEVELMSSDSSSSSSSDE
The following text describes a protein:
Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDIDAEREKITQEIQELERILYPGSTSVHFEVSESSLSSDSEADSLPDEDLETAGAPILEEEGSSESSNDEEDPKDKALPEDPETCLQLNMVYQEVIREKLAEVSQLLAQNQEQQEEILFDLSGTKCPKVKDGRSLPSYMYIGHFLKPYFKDKVTGVGPPANEETREKATQGIKAFEQLLVTKWKHWEKALLRKSVVSDRLQRLLQPKLLKLEYLHEKQSRVSSELERQALEKQIKEAEKEIQDINQLPEEALLGNRLDSHDWEKISNINFEGARSAEEIRKFWQSSEHPSISKQEWSTEEVERLKAIAATHGHLEWHLVAEELGTSRSAFQCLQKFQQYNKTLKRKEWTEEEDHMLTQLVQEMRVGNHIPYRKIVYFMEGRDSMQLIYRWTKSLDPSLKRGFWAPEEDAKLLQAVAKYGAQDWFKIREEVPGRSDAQCRDRYIRRLHFSLKKGRWNAKEEQQLIQLIEKYGVGHWARIASELPHRSGSQCLSKWKILARKKQHLQRKRGQRPRHSSQWSSSGSSSSSSEDYGSSSGSDGSSGSENSDVELEASLEKSRALTPQQYRVPDIDLWVPTRLITSQSQREGTGCYPQHPAVSCCTQDASQNHHKEGSTTVSAAEKNQLQVPYETHSTVPRGDRFLHFSDTHSASLKDPACKSHTLMKERPKQPLLPSSRSGSDPGNNTAGPHLRQLWHGTYQNKQRRKRQALHRRLLKHRLLLAVIPWVGDINLACTQAPRRPATVQTKADSIRMQLECARLASTPVFTLLIQLLQIDTAGCMEVVRERKSQPPALLQPGTRNTQPHLLQASSNAKNNTGCLPSMTGEQTAKRASHKGRPRLGSCRTEATPFQVPVAAPRGLRPKPKTVSELLREKRLRESHAKKATQALGLNSQLLVSSPVILQPPLLPVPHGSPVVGPATSSVELSVPVAPVMVSSSPSGSWPVGGISATDKQPPNLQTISLNPPHKGTQVAAPAAFRSLALAPGQVPTGGHLSTLGQTSTTSQKQSLPKVLPILRAAPSLTQLSVQPPVSGQPLATKSSLPVNWVLTTQKLLSVQVPAVVGLPQSVMTPETIGLQAKQLPSPAKTPAFLEQPPASTDTEPKGPQGQEIPPTPGPEKAALDLSLLSQESEAAIVTWLKGCQGAFVPPLGSRMPYHPPSLCSLRALSSLLLQKQDLEQKASSLAASQAAGAQPDPKAGALQASLELVQRQFRDNPAYLLLKTRFLAIFSLPAFLATLPPNSIPTTLSPDVAVVSESDSEDLGDLELKDRARQLDCMACRVQASPAAPDPVQSHLVSPGQRAPSPGEVSAPSPLDASDGLDDLNVLRTRRARHSRR
The following text describes a protein:
Function:
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly. PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MLTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGRDE
The following text describes a protein:
Function:
Regulator of plasma phosphate homeostasis. Decreases serum inorganic phosphate (Pi) uptake by regulating the sodium-phosphate cotransporter SLC34A1 trafficking by PTH and FGF23 in the kidney.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
Sequence:
MEQGSGRLEDFPVNVFSVTPYTPSTADIQVSDDDKAGATLLFSGIFLGLVGITFTVMGWIKYQGVSHFEWTQLLGPVLLSVGVTFILIAVCKFKMLSCQLCKESEERVLDSEQTPGGPSFVFTGINQPITFHGATVVQYIPPPYGSPEPVGINTSYLQSVVSPCSLITSGGAAAAMSSPSQYYTIYPQDNSAFVVDEGCPSFADGGNHRPNPDADQLEETQLEEEACACFSPPPYEEIYSLPR
The following text describes a protein:
Function:
RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.
Sequence:
MQPSALNERTRGAHGRISSGLGGNSSWGMSDIWRNNMDDSVARSTIEGISGSSSLLPSSESDGWDIRRNVPWPSRAQGNGMATSPVQNRSNDLGGVLVDGNDASSYFTQSVSSTLGPSPGTGQVTYLDSGSERISPAGETSAMGNRVLFNNNDRRSVGLTGTAGTAAYPAQSGFATPLESARSEHKGTMSMSSMQTLADNIQRGQIRNGYAHSSHNSTSNASQRPNHAAFPSFCSDTPFPNRYGNNPTELSTSLERMQMSETPNATSRPPYVSHASLDTSLSRLRHQVSRDEDSYQAAQGYGNEFLPQNPALAYQIAQSPHIRERDIVTYGDYPLNGAYYNGRPAGSNSGGRYRHGFANNAQENQLPGLQGRLREDIPVESPYQVSHMLARQRQFTPAYDYGYQSPAALASIYPVAQLNATALTTRLPSREHGSPQESWGPVLADFRLHGKNKRFELKDIYGHIVEFSGDQYGSRFLQQKIETANSDEKDRVFREILPNFLQLAQDIFGNYVAQKLYEHGNQTQKKMMTEDMRSKVVKLSLSPYGCRVVQKALEHVLTDQQAWLVREIQPQVLECVESQHGNHVIQKVFEYVPTQYTKGLVDSFRGQVERQSTHSYGCRVIQRMLEFCEDVDRRFILAEIRACAPRLIEDQYGNYVIQHIIQSGEEEDRSFMIEMVKQKLLWYSKHKFASNVVEKSIEFGNEAQRQDIITRLTAKTEGHETQLIELMADQYGNYVFQKVLGHLSGVERAALVDRIKPLLVHLKKSNCGKQIAAIEKLIGDSSPSPNPAIPASNHASSTTPPNSHKSSPQPVKRAVEERFVATPPTPPPTDNQSNGEGTAVSAELTGPMQ
The following text describes a protein:
Function:
Probable thiol-disulfide oxidoreductase that may participate in various redox reactions.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAAFTSTTTAAAASPTPCRPAALVARSSAAPLRSAAPVVVAAGLRRAAAPSRRGATLRVQAKKQTFSSFDELLEKSEKPVLVDFYATWCGPCQYMVPILQEVSEKLGDKIQVVKIDTEKYTSIANRYQIEALPTFIIFKNGKPCHRFEGALPANQLIQQIESALEVAK
The following text describes a protein:
Function:
Component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Has a role in regulating heterochromatin propagation and euchromatic transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSQKNFFDEGKSYGVNDYAGFHFENGADSSLPQVSAQGVVRETDSSNFDASPVASGSGISDVGPFGADFHQLQQHVQTPYGGMTMPASSSSGATSVPPEQDPSLSVSFNRLPKSASTKTKNGRIRSSRREDDNRIPFYDLDVAEGAEDDLQEDFHVEGMKTKSGRKIQRPVAYNPNATALKRKSRKVDMVTLCSVCQRGHSPLSNRIVFCDGCNSPYHQLCHHPPIDDATVQDVDAEWFCMKCQYRRAKQPLETGMTAQDLGLSESDKKMYLSSLPTPHLADLILFCEKSYPSLPIYNPRTRELLGEIRHQLLVSSERQQISLQERLHAKQDEAPSDEPAPVPYTASYVANSGTLYDYPTLIRLAIRNTLSPSKDEIFNWLAQNVPLLPTFHDSASEAIRWMVNKGQLVRSGSIYQIATVEEYPHLQPSLLPTFQRNRKVPKLVPVSFPTDDPQNLCATVL
The following text describes a protein:
Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
Sequence:
MSFQSLNPVNKSKSLVALSKSLSYVLRHGAEKEGLKIDSQGFIKVDDILKNNLFKNTNFKEIQEVVDTNDKKRYHMELNDSDGCYYIRANQGHTLENVDNVEMTKITSADQVGTVFHGTYRKHLQSILNEGLKKMDRNHIHCVNKIMGQEITSGMRGSCNMIVYIDVPLLLQDGIDLYLSQNNVALTDGLNNTGILPPKYFIKITDAKNDVTIWQHMRVKKKKIFIFIFFFFFFFFFFFLIFVLSNYFFFIFFIFFHFFFAPNPNFSNTHFGLGPQKKK
The following text describes a protein:
Function:
Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor VPS10. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS29-VPS26-VPS35 subcomplex may be involved in cargo selection.
Miscellaneous:
MISCELLANEOUS: Present with 259 molecules/cell in log phase SD medium.
Sequence:
MLLLALSDAHIPDRATDLPVKFKKLLSVPDKISQVALLGNSTKSYDFLKFVNQISNNITIVRGEFDNGHLPSTKKDKASDNSRPMEEIPMNSIIRQGALKIGCCSGYTVVPKNDPLSLLALARQLDVDILLWGGTHNVEAYTLEGKFFVNPGSCTGAFNTDWPIVFDVEDSDEAVTSEVDKPTKENQSEDDDAKGGSTGKEQPGSYTPKEGTAGERENENESNVKPENQFKEDEVDMSDSDINGSNSPSFCLLDIQGNTCTLYIYLYVNGEVKVDKVVYEKE
The following text describes a protein:
Function:
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries.
Subcellular Localization:
Nucleus.
Sequence:
MSFANTKCVVEEGDTVIIYVNPQAMYALQVKPLIATKKGDMVENIFQTAYGALKVQELVGKKFGHKVQFSRGWGYLLHPTPELWTLNLKHRTQILYTPDISLIVMQLDLKAGSVIVESGTGSGSLSHAILRAIAPTGHLHTFDFHQQRVEIVTQEFSDHGWEPFVTAKQRDACKDGFDLENVADAVFLDLPNPWLAIPHSVKALKKSGGRICTFSPCIEQTQKTCEGLLAEGFKYIETMECLQREYQVKNITLPEIDDYNFSFCNTPETNCEGNQKKDDRKFRAVLPALQMAGHTGYLTFATWPRQSEKCQT
The following text describes a protein:
Function:
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, ruffle. Synapse, synaptosome. Note=Highly expressed in the perinuclear region. Enriched in synaptosomes. Also enriched in membrane ruffles and at the tips of lamellipodia.
Sequence:
MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCASSSSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDNAEEYERATRYNYTTEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTKFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSVVELDGLLEINRMTHKLLSRYLTLDSFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAVLFCLLIEQSLSLEEVCDLLHAAPFQNILPRIHVKEGERVDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRTFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGESTPVEHVRCFQPPIHQSLASS
The following text describes a protein:
Function:
Serves as substrate adapter subunit in an E3 ubiquitin ligase complex zyg11-cul2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation.
Sequence:
MEESSPKSLLDITLLYLSTHLEKFCWERQDGTYCLQDAAIFPQEVADRLLQAMAVQRQLNEVTVGIFRGNQLRLKRACIRKAKISAVAFRKAFCHHKLIELDATGVNADITITDIISGLSSSKWIRENLQCLVLNSLTLSLEDPYERCFSQLSGLRVLSITNVLFYNEDLADVASLPRLESLDISNTSVTDITALVACKDILKSLTMHHLKCLKMTTTQILEVIRELKKLNHLDMSDDKQFTSDIACRLLEQNDILLHLVSLDISGRKHVTDKAVEAFIRHRPQMQFVGLLATEAGYSEFLSGEGCVKVSGEANQTQIAEALRRYSERSFFVREALFHLFSLTHVMDKANPEMLKLVVIGMRNHPTNLPVQLAASACVFNLTKQDLAAGMPVKLLADVTHLLLEAMKHFPNHQQLQKNCLLSLCSDRILQDVPFNRFDAAKLVMQWLCNHEDQNMQRMAVAIISILAAKLSTEQTAQLGAELFIVRQLLQIVRQKTSQNMVDTTLKFTLSALWNLTDESPTTCRHFIENQGLELFMKVLETFPSESSIQQKVLGLLNNIAEVKELHTELMCKDFIDQISKLLHSVEVEVSYFAAGIIAHLVSRGEETWTLSSSMRETLLEQLHSAILSWPTPECEMVAYRSFNPFFPLLACFRTPGVQLWAVWAMQHVCSKNPVRYCSMLIEEGGLVRLHRIRDHMCADPDVLRITITILDNLDRHLKKHGNPPCQKPPFTK
The following text describes a protein:
Function:
K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. In trigeminal ganglia sensory neurons, the heterodimer of KCNK10/TREK-2 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency. Permeable to other monovalent ions such as Rb(+) and Cs(+) (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Each subunit contributes two pore-forming domains 1 and 2 which assemble to form a single pore with M2 and M4 transmembrane helices lining the central cavity and M1 and M3 facing the lipid bilayer. The transmembrane helices are bridged by the selectivity filters 1 and 2 carrying a signature sequence TxTTxGYGD that coordinate the permeant ions. Up to four ions can simultaneously occupy the selectivity filter and at least two elementary charges must translocate across the filter to convert it into the open conformation.
Sequence:
MYFSYIGYFFLPPLVAVPAAAPPVCQPKSATNGHHPVPRLSISSRATVVARMEGASQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHICVSPQELETLIQHALDADNAGVSPVGNSSNSSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLTKHGQGASEDNIINKFGSTSKLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEDETEKMCNSDNSSTAMLTECIQQQAEMENGMVPTDTKDQGLENNSLLEDRN
The following text describes a protein:
Function:
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
Sequence:
MEIVRPQWKPPSNDVVSTLPLYRSAPALEVRLEDFELYAMDRLRVLKGISDGLSRGKKAEEMEKLVNDLWKVNMKHPKAVEVLDKDVISHFVLRLVYCRTEDLRKWFLSMETALFRYRFRLLAADAQRALLTEFGLPYRMVARAEFEGIKEKLVQVARSIGQPMLSSDAIFYKVPFEEVPELVAGRKVFICKGHAYVAMNQVVSLVVTQFRSLLSKALILTNRKWTSAIREQEKDRLTPIVEALCSSYLGPDYSQPKEFAEISIKDIDLVAKSSFPLCMRHLFEKLREDHHLKHGGRMQLGLFLKGVGLKLDDALAFWKAEFSQKVGAERFDKEYAYSIRHNYGREGKRTDYTPYSCQKIISLTPGVGDHHGCPYRHFSEENLRAALCRMGVNGSAVEDVMDKVRNRHYQLACTLTFEAIHGLSCDAGINHPNQYFSDSQKTLKVKSHSSEQRESTVD
The following text describes a protein:
Function:
Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to active genes.
Sequence:
MHASSAAATALVEYSDVSSEDFSDQEAGDLDADAGKGAGNIKKPKPAPDNQFSKGRLDAKPDKEGYDNYRSRRAEDSSDPVAAGSRQTSSSEATNPREEPSQASNTSKDELWGREIYMSSDSIDTDELEAEMKRQKRKKQKKEKHKHKSKKKSKKRKKKRAKSYSSIDSMSDNDINALLDRRYTPPTAPSKSNERTVSAAPSSFTPHNLKESSSPATPPPVRRPNTNSNYYGESSLETANSALGSNLQVTVTNKQSISNRLRSPPPSSRSSGNGPRFGNSPRTPPPSHYSSSGGGGVGSGSVVRDSRSSRYVNSPHKEDVSAHHRSSHDHGYQGRYSGAGSSSHDTRKVKRLSPELDRYNHQPSTPPHKRRKFSDGREVGLGNFEHSRHHSGKYERYSRDRYSRRSSRSPSVQHSRSRQSPSGGLSSGSNAFRHGGSHKHKYGTTVSSTPSHTTRTSKRASGTGTSGDRYSRSPRTSSRYMESSPPSPVGASGSHHYHHRRSPRMRQRTRGDSRRRSPSSASSESSASRSRSPTSRDLKHKREEYIKKISETSLFAELVKDRHKRQKALKEIIERQEENSNSNSNGALTINDNSSSVDGNTPNAADGRSAPGSGTPAAASTTSNGLQALGSKPDLDLNNIPMPNKQNDSVVSNPASNADVPDSVAQLKQPLLVPPFSASKNNIKPKSLTSLPLPPGMNVLDLAGARSPSPGQKKESDEKNVTSSGSANKSVLNLPMPPVIPGSEELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILNRRDSRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHELWSKKRRRQMREQQESLPPTVIASTKYQQHGATMVGDA
The following text describes a protein:
Function:
Required for efficient chemotaxis.
Subcellular Localization:
Mitochondrion.
Sequence:
MNKTIIINNVSKYIKFKNYYSSSSTILKKKTSEIYKIKGLDIKDRKELYSLNNDSIKKKLNQLKDETNQLLKERGEELMKDLSKTLNLTSDNLKYNITKSPFTLRAYLLAANQGISFYHHELRKQINPTDDYERQKRKDLVYKLQSQEIDSLTSGGANKKKSPFLEDNNNKKSMSIEREMEIIREQQQEQQHFDQQMSNSTKWEMSQLEIQPRIDTFRQDELFVSFNPYESMSTNSQSYQLVSRLSKFVWNKELTNWEMFSSSKLNQLIPQLQLHILDKINLNNDNDNDNSIIINQFLESIKFISNEINSTDLNIFKTLNSSNNNNNSSENIIEVENGGDFKKIINNSIVDSLIYMKGHHFRITSDPFILFFQQLKENQDYFTSNEDYKQFLEKLLDTLLFETIEFDPTSTTTINGNRQFEYKLKLDLLQREAFRQFKVYQVFNTSPDAKRHEESDLRKLAHLCKTLQKRSTSDFIQESKKYLSPQILSNGLLNSNKLLVATSSSNELNQSKTSISISQLTDGLHSCIPATMSLLEFSIKNSSKDNILFDTFDGKLKNINSLDDLITKFANSKYIYLRESLSQRFSMFIQSSNNTTDNNTTTDTNDNDIIIGLNNPIYKLLIDLEDKVLELSQNNFEENPIENWIGCLSIELGDEDDNIEYKDTDQFNVIASQNFNLVRINNQMLAQLHKTFSEDLDFQIEELELMIKNKKILEREIKAHNEKISKIIKDSRDSTTPTFYFIGIQDDQVYTLEIPNEWEPVWNLLKSYPNGLLLKDFIDKQTFVTKEAFLSTLTDLNKYGVVGLFPKN
The following text describes a protein:
Function:
Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes to the matrix side of the mitochondrion inner membrane.
Sequence:
MQLWVCLQPQGALRLRASKMDTIIRRCPFLSRVPQTFLQKAGKSLVFYAQKCPVMMDLASRPFARALSTSAAKCQETKETSPTDSASGQPPKQPSLPPGHPVPPACQAAASKCPFLAAEMGQGNSSVFRQASVELQEDVQEMHAVRKELAESPVNPTVVNITKADGEDQSSLLKNLLKQRPTRVSHLLQDNMPKSVSTFHYDKFFEKKIEAKKNDHTYRVFKTVNRRAETFPMADDYSGSQASKKEVSVWCSNDYLGMSRHPRVVRSIMDTLRQHGAGAGGTRNISGTSKFHVDLEHELADLHGKDAALLFSSCFVANDSTLFTLAKMLPGCEIYSDAGNHASMIQGIRNSGVPKFIFRHNDVNHLRELLKKSDPSTPKIVAFETVHSMDGAVCPLEEMCDVAHEFGAITFVDEVHAVGLYGARGGGIGDRDGIMHKMDIISGTLGKAFGCVGGYIASTATLVDTVRSYAAGFIFTTSLPPMLLAGAKESIQVLKSEEGRALRRRHQRNVKLLRQMLMDAGLPVVHCPSHIIPIRVADAAKNTEICDIMMSRYNIYVQAINYPTVARGQELLRIAPTPHHTPQMMNYFLEKLVKTWKEVGLEVKPHSSAECNFCRRPIHFELMSEREKSYFSGLSNLISASA