The following text describes a protein:
Function:
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPSEQFQEQQRQQQQQYQQQLERERQEKEQNEKESLISNLVSLIIEIQQLGGNEYNSQNHPINLSKDSIVDDKNNKKDLDTTSVTNNNKQQQQQNKTTHKIQQKYELYISRIRSILPELINSHLVSTASISDINQIVKLISYLIEKIPNSSLAIGDSSGDICFFLFKLIPFLSHKSSTNICSQQHQQLDENEEFTENLITAIKAMLNFLNDDANVLLLFFKETICLFKDCIDFIKCLNSSNNQQEQEKSIFPMVLKTYCELSSSVIINSNTTGNTSSYSKHYQSLDLLVQTEMAFNQYSKNNNNNNNNNNNSEKDKNIEKEKSNSNDDNSKSIDEGVIIVISSINRLINLQYGLLVSISSVIDNFSPILYSVSIDLWDVLSQYLFLLNDLKLSSFKYMANFIYSLLVLFEKLLKLSSNQIPALLYNNIVGQFFNVLLPMSMLLNDKDCSKRREEIDIKLTSIIPLLFSNVPSSTLFDFSSIILPNILFIINNTNLTELKVSILDIYLNILKLSELQFKSIYNLVPLFGDEGIHDKLYQCFDYVINQSYLIDTDDDDDDTDIDISLEILNTLIDYSNCLNISNIYESISTVTNSVKDKNIDNNTENIEKDDGDGGAGGTSENVNNKQIENQKSITEDSKQQQQQQQQQPTIEQQKSIRIYLKALHLIFKICKNHHNRVSVKELVNLFINNLNFIYDLIIQQKELDNLFLEVLMDLLKLSSTVEIEYLHRISTLKSNEQLLESLFKLSTIVTNHSTIFNLTKYAEIINSIKVISFSLVCWLPCSYYVNERVDIVLSTLSLNKSLVNSTTTTTTTTTTTTTTTTTTATTNTTTTTATTTDKSSSQQNVGESNKNNPTIVSSSPILVNISSDTSSSMGDSQAISASQQQQRNNNNNNKGEKYLSKLDQNYLINVIKLLPVFISNMSPVNSLATISTNHQYQIMCNDIIKRLESIIDLNVTSLILDMVGVIGGSLYCLKEGYCFFENLNRCTYLNNNNNNNNNNNNNNNNNNNNNNNIQEQNNLIIINNSILLQRFTDTKNNRIKIDPLLSNYNNLVGCGIFEGVWLPLCSCKCVTVSSVLNTNIVDLNLKPYRPIHKSPPSNNNNNNNEKDETIMDIDKTNNNEQILILESKYKENILFSKLFLEYHDGQNSDLDNDTSMMTSGGGDGDHDSSIKYFYLGFTFKNILIHNSPLPSTSIEGFFKFYLNLLSANRNDIIRKSVIKIIISMLKFNYQTNPDVLTNFFYQLHPLYSNKSEREDILFSILYLLKKIANLIIQSQKDQYILNNSLNNNNNNNNNNNVQQLSSSSSSHNNQLNNNNTTTTNNDSITWQDKIYSNDFILIIFCTLIENLSRQTTIKVNSIETIEFIAKKLNQTPKTLMMTNMAQYINPRIIENLYTNRQSLVELCRYFLGIGLNQFLISSLPTVIPVLIFKSSNNILNCLKDELKDLKELCGQDYLMGLIFEYIFIHATSVENLTSCIICFCRFADFNQDAVVSNLPKSFINSLILNLANGDGQQAKKALDYVSQFVGGDMTFDKFLIKEFLGSMNFFTMIMTNKQKSTQEKLTMMTSFHRLLGLMGQSVDLFRPKIMAFLRLAIKTPMEEIAIDAWFTFIQLLKLDSIGPILNQIVFSILPFVQSYPEKSLLIFDYLIIKNRTILKPYFKTIPFLPKEYTVLKPYIQELESSSANLTTQIKQLMELFSNESIEVKLMSTNKLKELLSANKSIIHEMIQLDSDPILINDLVKSLLIGCRDPYLKLSVNFLTCLGELGAIDPVKLDFSLRNQSTAEKDKVQIAAELIEKYLAKFVLSPSNPTPQDRAGYAIQEILKCCQDTKLSEKLSNECNDIIKPYYSSEYMLPLFSKKNNNLVGGGGGNGNGGGNGVSSSGSSSCFYGSNMTYKKWITSWLSDLLFKTKGSPGSANNDLDSIFMACRGIIKDDLKICHYLLPLVILNIIEYGRESDIQSIKNEILEVLNNNTDLSTDNGQICTQIIFHVINSLNNWIDVRKRKYFLTQQQRTASQKGKSKKLESPPDVVVIERFLNGIPEKILAFASYRCGALSTSLSYMESLIRNETSQILKQQQQQHQLNLQLNMQQQNLQYQQQLQQQQPQQQQQQQQQQQQQQVQQQQIPILNSSQPASMASARELALNNNLQLLQKIYHEMDDIDGLIGLSHKRVGSPSNEEKIVELESQGFWGDALLYYNTALERSPINMDLRIGALNCLFNLGQHESLLLQIEGLKQEPWLTNKDQSKLGTIKIQSSWRLSHWDKIDETLSQTHEPNFEAYLGRILYSLVKKQEKEFNSNLFQCRSFLAQLLNGSALDSYQRCYPYLIQAHILEEIEQSYKLIHYNVIPIENVTITNNNNNIGNNNNSNNNNVQKQQMLKKLLSEWDDRLKIIQPSFKLRESILSVRREILEIGSFSKEVIDCWMKIGKYARHDKKFELSLNAILKPTPSQQDKFYFIEHAKLMWNQGHSFEAINILTQELKNKWNPIINSNNNSSNNSSSNININNGSKLSLLGLPQEDLFIISKTHLLIARWKQQCGITHHSELTEHYSSATAFEWEKGFFFLGRYYDSLLSNLKRVNQNSPNSPPLDSVSYVDYTRNIISSYGQAVILGHSYIYQTLTRIIALWCELGVIFSDFKIPEKSTKVTSDSLESIKKAMSKLELDVPASNWLMFLSQVASRICHKNTDTWLILEKIIIRTMIEFPKQSIWIMMMQYRSSSSIRKQRARTCLEKARKTDAIKKNQDETILLCAQLLAVSNHPKKANKRYSIKMSEIFKKLYEMKDLTVILPLQSSLNVSLPPNGKPDKSYPAFGSLPLIGSFEDQIDIMPSLQGPKKINVNDRQGNRYSFLLKPNDDLRKDQRVMEFNTMVNKLIKKDPACRKRNLKIRTYTVIPFNEESGIIEWVSNTATLRSILGGIYETMDTIGIDRFNQMVNAKKEKHYLDLFEDFNRFFPPVLHKHFITNFPEPSAWLDARDAFARSCAIMSMVGSVLGLGDRHTENILLDSITGECVHIDYNCLFWKGETFTVPERVPFRLTRNMVDVFGVLGVEGTFKTVCENTLRVLRSNKEVLLRVLENFIYDPFLILFDKKNQNSNNNNNTHFGEVENDQAVEILKRISATLQGIPTVGLQLSIEGQVNHLIQEATNPKHLCNMYVGWCSWY