lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Has oligopeptidase activity and degrades a variety of small bioactive peptides.
Sequence:
MTTIKTLPKRAEVPREQTWDIEALYATPAAWEAEADALSTDIAGLGASAGTLGESPEGLLAYLKAADDLEQRLTRFMSYAGMSASVDGRDAVAAARRDRASGIGAQYGSAAAFALPELLELDEAQLRGWLEREDFADFRIALERLLRDKPHVRSAEVEELLGAVQAPFASERGIHPALANMDLDFGSAGGQKITQGNVDRLTSDPDREIRREAWEHYADAHLAAKHSQAAMYATNVRQNVFLARARRYPDAITASLSPDNIPTEVVTTLLDTYRANTPIWHRYWKVRRDWLGLSELREYDVKASLVPPREVSYAQAVEWIAEGMAPLGEEYVNDLRFGLTEDRWVDYAENDGKRQGAYSNGGGRVKPYIFMTWNGTVGSYSTLAHEIGHSMHSLLASREHAPSVPRYTLFHAEVASNFNQAMSRKNLLAKARAAGDTEMEVAIIEEALSNFHRYFFIMPTLAAFELESYRRIEAGGTLSAPDLIDLTADLLGQGYGDGVTMDRGRSGSLWMQFSTHLYANFYAYQYATGISAAHQLLEKFDADPEGARESYLRYLKSGGSLDPIDALREAGVDMLSPEPVQATFRTLEGYVARLEELLAARQAN
The following text describes a protein:
Function:
May have a role in lysosome distribution by interacting with Arl8.
Subcellular Localization:
Lysosome membrane. Note=Localizes to the perinuclear region when associated with Arl8.
Sequence:
MPGFHLNEMGEMVLDAIDDIGVVDVYDLASDIGKEYERIMDRFGTDAVSGLMPKIINTLELLEALATKNERENATIQELRDKVAQLESEKLEKAEFRRRFDKELELIEEQWRSETNELVDLVSSLQDENKRLVKQTQDLQSSSAQSSGLGASLTESIISMTNHELHSALSDTQVLQRLKEQIYKQRDELKHRERELQDKYSELEHLNIQAERLKASERDTRRRHKLMQAQVKTLCEERADFLAQLQDQSREINQLRKRLGLAEKENEDLVASYDDGQNDPNRPRYTTRELKELISERDELLTTIDTLNEQLAELKPPSQAKGKRQRHFSSSDDSDEDDDGHVADNDDDDDEEEAAAEANELEPPAAGETPPGHDAPVQGPLPYEPDDAPWKKSSESGIRKFFRKLFSDPSDGSNTFPKRSLATLSKMALSATPGSVSASAAAK
The following text describes a protein:
Function:
Acts as a MHC class II receptor. When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells. Does not act as an Fc receptor.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif is involved in PTPN11 binding.
Sequence:
MLLWTAVLLFVPCVGKTVWLYLQAWPNPVFEGDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKENQTLSMGAATVQSRGQYSCSGQVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPREGSLVTLRCQTKLHPLRSALRLLFSFHKDGHTLQDRGPHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQLEVRVQAPVSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGTTSLLFPVKSEQDAGNYSCEAENSVSRERSEPKKLSLKGSQVLFTPASNWLVPWLPASLLGLMVIAAALLVYVRSWRKAGPLPSQIPPTAPGGEQCPLYANVHHQKGKDEGVVYSVVHRTSKRSEARSAEFTVGRKDSSIICAEVRCLQPSEVSSTEVNMRSRTLQEPLSDCEEVLC
The following text describes a protein:
Function:
Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids; Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSSLSSELKAKEIFNQFATEGANEEKIITLPDFINVLSPFTTDIPKQAFSLLYLIADAEKKGFVTEDNWLKFVNTLTSPDGEYKLLYQFLSGQQNTNSKITYSQCIDILNKINSSIDPSYQQKLIKLNWIYFPRFFEPNGSIEFNDFVTLISYLPVTKLIGNFEITASKSKTVNGEELVRLLSTNLNHKLSNKLKINLHNVTDFFGKQQDYTLSNLLFIYDALSKVDLINEVIVNTPPTTKDKDDILINKTDLYNHLNDPLLKSANFKPVSRLELDLLFYLINKKTDEDIPRRELVSFLNPNFNNNLNTLAPIFEHSQSKHSTIDGGDNFSLWPLYDSLYSFFLGSIAGCIGATAVYPIDLVKTRMQAQKHNALYDNSLDCFKKILRNEGFKGLYSGLGAQLVGVAPEKAIKLTVNDLVRGIGSNEDGSITMKWEILAGSTAGGCQVIFTNPLEIVKIRLQMQGNTKNLSKPGEIPHKHLNASQIIRQLGLRGLYKGASACLLRDVPFSAIYFPTYANLKKHMFGFDPNDKTKHQKLSTWQLLVAGALAGAPAAFFTTPADVIKTRLQVAGKKNEAKYKGILDCGASILKQEGLSAFFKGSLARVFRSSPQFGFTLASYELLQNLFPLHPPLTRESSFKGISGYPGVYNLTNDQVYNSQEKNERLILMNKSELSPSPSSSSSSLDTVNDTLVKLPAEYIYKSQDAVKLLLDIDYKFGNFNYDSYVNYIKKK
The following text describes a protein:
Function:
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
Subcellular Localization:
Mitochondrion.
Sequence:
MNSSTIRRSIGLTGSLARQKRVNRSSPLPAAQDPQAGPSGSKAVTEEAPENRLFNHSQEQKDEDKPQWLIHKEALRRKFPDGWNPPKKISRPSMALLRTLHQTDPNQFSLSILSEKFKISPEAVRRILRSKWEPNQETAKKTEQRQQTVGAAHSSDGWVHHEKLETDQIPLNLAHTLQSSLPSSSKISSSSFPRKSQPRSSYNHFKK
The following text describes a protein:
Function:
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies. Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. Exhibits decapping activity towards dpCoA-capped RNAs in vitro.
Subcellular Localization:
Peroxisome.
Sequence:
MRVRVRTRCFPKSPAACRKGTAGPMPRPCGLQESVRNNLIDDAKARLKKFDVGTRYSHLSPSKYSVLLPLLARGEKLYLLFTVRSDKLRRAPGEVCFPGGKRDPVDADDTATALREAQEEVGLHPHQVEVVSHLVPYFINKYALSNIVPFSVDVTSFPCPQQEERNNDLVTPVVGFLDPDFQAQPNADEVKDVFLVPLDYFLCPQVYYQSHFTHSGYHFVLHCFEYTDPETGSKYLIKGMTSKLAVLAALIIFEKSPSFETEFDLHDLIPSCEKTFLHRCSSSKL
The following text describes a protein:
Function:
Protein kinase that acts both on serines and on tyrosines. It acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylates and inhibits cdc2.
Sequence:
MDSSTTIPITPTRTPCFFNISSSFNEHSPLNFYDEPIYNFSSGHEENQSHKSSKLTFFKPSNTKRSPHTPMQNNAKAIRLSTTVRHGIFKNSDLDGCSKPFAFSSGLKLSKKIVDASTPIDLKRKRAVTSLSTGLLSKREKWSLWEGNLTNPRSEQPHTPCKKGTKIKLKPPQSPLSPTTSLLARKCKHIDLDTFSRLDHPNSDSSDETFEMEELPSLSYGSEDLLEFCETPCKSQPIFLSSSHVNNWDEKDVPSSLSWTPTSPIFLNINSADDYEEEEDWTSDLRIRFQQVKPIHESDFSFVYHVSSINPPTETVYVVKMLKKNAAKFTGKERHLQEVSILQRLQACPFVVNLVNVWSYNDNIFLQLDYCENGDLSLFLSELGLLQVMDPFRVWKMLFQLTQALNFIHLLEFVHLDVKPSNVLITRDGNLKLGDFGLATSLPVSSMVDLEGDRVYIAPEILASHNYGKPADVYSLGLSMIEAATNVVLPENGVEWQRLRSGDYSNLPNLKDLLLSKEKVQINKVRCAESLQCLLQRMTHPYVDCRPTTQDLLAMPEMIFISEHSQKAAIIYEDHNSWLET
The following text describes a protein:
Function:
Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway. Cleaves alpha-1-antitrypsin.
Subcellular Localization:
Secreted.
Sequence:
MCTRRHVRTQGGTDTGMCAHRHVHTQGGTDTGMYTRRWAPTRECAHADTCARRGALTPGRAHAGGHRHGNVHTQARAHSDTCSRRHVQMQTRTHAGGHLHGHMRTCRHVQTRTRAHAGGHLHASARSHRWGLPQPAGTPHWKGRSVRAPGPPAGASVSPQRFLSKYGWADAPRGPRAPPAAAALAQAVRRFQKVNALPASGRLDAATLAAMNRPRCGVPDTRALPPPAAPPRPKRFLPPPPPPGAPPPEVSAPRGAPRAFAKRTLSWRLLREGASGQLAEAEQRRILRLAFRMWSEVMPLHFREDLAAPGAAVDIKLAFGRGRHLGCPRVFDGSGQEFAHAWRLGDIHFDDDEHFTPPTSDAGISLLKVAVHEIGHVLGLPHTYRAGSIMQPNYVPQEPVFELDWSDRKAIQKLYGSCEGSFDTAFDWIRKERNQHGAVRMRFSTYFFRNSWYWLYENRNNRTRYGDPIQILSGWHGIPTQHIDAFVHLWTWRRDERYFFKGNQYWRYDSDKDQAYTEDEQGNIYPKLISEGFPGIPSPLDTAFYDRRKQLIYFFKESLVFAFDVNRNQVLDSYPMKITEVFPGIEPQNHPFRNIDSAYYSYAHNSLFFFKGSAYWKVVNDKDKQQHSWLPSNGLFPKQSISERWFDICDVHASTLTV
The following text describes a protein:
Function:
Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex of the photosynthetic electron transport chain. Functions in assembly or stabilization of the NDH complex; probably involved, together with CRR1 and CRR6, in the incorporation of NdhJ, NdhM, NdhK and NdhI into the NDH subcomplex A assembly intermediate (NAI500) to produce the complex NAI400.
Subcellular Localization:
Plastid, chloroplast. Plastid, chloroplast stroma.
Sequence:
MALSFVSSTRFSKMQYGIWHSGSFTQRVSVRCCEIANEAPRPKSKLQVGSPIIIVEAPKVIKTAASMPCLRANSGLVKPGDVGRIVSRKPKDLWAVRLSIGTYLLDGKYFKALELDEGDSD
The following text describes a protein:
Function:
Phosphatidylglycerophosphate (PGP) phosphatase involved in the biosynthesis of phosphatidylglycerol (PG), a phosphoglycerolipid predominantly present in chloroplastic thylakoid membranes and which has important photosynthetic function; seems to use PGP 34:3, PGP 34:2 and PGP 34:1 as substrates. Required for thylakoid membranes development and chloroplast function. Necessary for normal cell growth. Required for root growth and columella cells organization.
Subcellular Localization:
Plastid, chloroplast. Mitochondrion. Note=Localized in chloroplast of leaf mesophyll cells, but in mitochondrion of root cells.
Sequence:
MQTPSMAASTTSYYPIPKSFLLSPPRHKRNPNLISCSTKPICSPPPPSSSSSSPLQTTTTHRSQKQNLRLPTFEDSFLLYQFSSPTEDPGFSNRIPEQFDGEPRELVLPRVEDNNKGLAISSNMWWADLKAALGQRINIEGIVSSVSVVVKDRQFVLPHVSVKDLRYIDWEVLKRKGFKGVVFDKDNTLTAPYSLAIWPPLRPSIERCKAVFGHDIAVFSNSAGLTEYDHDDSKAKALEAEIGIRVLRHRVKKPAGTAEEVEKHFGCTSSELIMVGDRPFTDIVYGNRNGFLTVLTEPLSRAEEPFIVRQVRRLELALLKRWLRKGLKPVDHSLVSDITQFVKVPSDL
The following text describes a protein:
Function:
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Sequence:
MAEFQRLGIQRWLSEQCTYMALETPTPIQCKCIPAILAGRHVVGGAATGSGKTAAFALPILQTLAADAYGVFALVLTPSRELAYQIIDQFIAFGAPLRVRTMLAVGGVPTETQVDALKARPHIVAATPGRLRHLLEVFAPEVQKAFAHLRYLVLDEADRLTEGDILRDVQSLLRLLPPTRQRRVLMFTATLHPRLTTLEVPQAAQGLSASGGAAEERAGASLASSHSPALQQPQNGEVDEVAEHFSLLAELGITDASTLEVAVVRGAIQEGLGHAAESGSTGAAGGPTSSATAPTLPGRPTSFHLPETLTQNYLFIPNMVKLPYLVAALRLQGKEQSTIVYVNSCLRAELVRLTLQLLGFPVCSLDSLLTQQHRLDNVASFKLGIARILVCTDIAARGLDIPAVSLVLHYDVPKHAETYVHRVGRTARAGREGTSVALVTEYDVSLVQRIEKKIGTTLTLWKSPAAKESAILSLLDEVSSAKIQARQQVTEQFGARVQTNKEHAARKKVAAAAARAARSSRQRRQQQEQRLPSAEPNATASMADTASPTSLSGLKRARRSVTSAEDAPTQAGVVAKKAKKGAAVRGLAADATASRRSATQQRPAKKSATGESDRSPSRKRVKEAA
The following text describes a protein:
Function:
Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine. Also involved in condensing pyruvate and 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate.
Sequence:
MSAPTKPHSPTFKPEPHSAANEPKHPAARPKHVALQQLTGAQAVIRSLEELGVDVIFGIPGGAVLPVYDPLFDSKKLRHVLVRHEQGAGHAASGYAHVTGRVGVCMATSGPGATNLVTPLADAQMDSIPVVAITGQVGRGLIGTDAFQEADISGITMPITKHNFLVRSGDDIPRVLAEAFHIAASGRPGAVLVDIPKDVLQGQCTFSWPPRMELPGYKPNTKPHSRQVREAAKLIAAARKPVLYVGGGVIRGEATEQLRELAELTGIPVVTTLMARGAFPDSHRQNLGMPGMHGTVAAVAALQRSDLLIALGTRFDDRVTGKLDSFAPEAKVIHADIDPAEIGKNRHADVPIVGDVKAVITELIAMLRHHHIPGTIEMADWWAYLNGVRKTYPLSYGPQSDGSLSPEYVIEKLGEIAGPDAVFVAGVGQHQMWAAQFIRYEKPRSWLNSGGLGTMGFAIPAAMGAKIALPGTEVWAIDGDGCFQMTNQELATCAVEGIPVKVALINNGNLGMVRQWQSLFYAERYSQTDLATHSHRIPDFVKLAEALGCVGLRCEREEDVVDVINQARAINDCPVVIDFIVGADAQVWPMVAAGTSNDEIQAARGIRPLFDDITEGHA
The following text describes a protein:
Function:
Involved in reactive chlorine species (RCS) stress resistance. Up-regulates, in response to hypochlorous acid (HOCl), the expression of three genes essential for survival of RCS stress (rclA, rclB and rclC) and its own expression.
Sequence:
MDALSRLLMLNAPQGTIDKNCVLGSDWQLPHGAGELSVIRWHALTQGAAKLEMPTGEIFTLRPGNVVLLPQNSAHRLSHVDNESTCIVCGTLRLQHSARYFLTSLPETLFLAPVNHSVEYNWLREAIPFLQQESRSAMPGVDALCSQICATFFTLAVREWIAQVNTEKNILSLLLHPRLGAVIQQMLEMPGHAWTVESLASIAHMSRASFAQLFRDVSGTTPLAVLTKLRLQIAAQMFSRETLPVVVIAESVGYASESSFHKAFVREFGCTPGEYRERVRQLAP
The following text describes a protein:
Function:
Required for protein translocation and folding in the endoplasmic reticulum (ER). Probably functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2. It is not required for viability but is essential for optimal growth at elevated temperatures.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MKFSKTLLLALVAGALAKGEDEICRVEKNSGKEICYPKVFVPTEEWQVVWPDQVIPAGLHVRMDYENGVKEAKINDPNEEVEGVAVAVGEEVPEGEVVIEDLTEENGDEGISANEKVQRAIEKAIKEKRIKEGHKPNPNIPESDHQTFSDAVAALRDYKVNGQAAMLPIALSQLEELSHEIDFGIALSDVDPLNALLQILEDAKVDVESKIMAARTIGASLRNNPHALDKVINSKVDLVKSLLDDLAQSSKEKADKLSSSLVYALSAVLKTPETVTRFVDLHGGDTLRQLYETGSDDVKGRVSTLIEDVLATPDLHNDFSSITGAVKKRSANWWEDELKEWSGVFQRSLPSKLSSKVKSKVYTSLAAIRRNFRESVDVSEEFLEWLDHPKKAAAEIGDDLVKLIKQDRGELWGNAKARKYDARDEL
The following text describes a protein:
Function:
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MTVTESSEHDGEKDENSAEAPSEDDKNVLTSYIQEVEERFVCKQELRSANQNAANTRPSESHFSKLDSSLKKNTAFVKKIKNFSANQVDTYLKDMTGLNLSKYISEIAAAIVDAKLKMTDVGAAVKMCSVLHQTYADFSQHLFENWQKTLAFKVGEKIPNPSKLRVDLRFYAELVQAGVFSNKNAFTLLGTVITTLVNMDKDEHYNCSIILSFCKHCGEDYAGLVPRKMRELSEKFDIPIPKSTFLPPEKQQNVRTLLRDYYVSLSKHLVKDHQEIQNFEKQNMRILQTKGELSQERKDKLEALQTSYDKLLASTQSFAEILDEDMPTLKNQTLMKNDESMIVTGAGPDLDEAALANIENVWCDIETQRFYCELPELQAFLPTSYINKQAPPPEESVTEEVLDSEIPTEELEDDEKAEEAPVAAEDEPEDSATTNASNKILLEAFFNNLPNCVNREMIDNAAIDFLVTLNNKHNRKKLVRALFGVNRTRLDLLPFYARFVAILRPALPEVGNELCQMLRQDFKYHVRKKDQINIESKIKVVRFIGELVKFKLYSKIEALYCLKVLLYDFSHHHIEMACNLLEVCGRFLYCSPDSHQRTRVYLEQMMRKKAVMALDSRYVTQIENAYYYVNPPEVTITKKERPIMHQFIRKLLFQDLQKNNTDKIMRLIRKLDWGNEDVSAYAIKCLSSAHNVKYFNIRCLANLLAGLVTYQEEVGTRVVDSVLEDIRLGMEVNLPKYNQRRVAQVKYLGELYNYRMVESADIFKVLYSLITFGVSMDPNIPSPLDPPNHLFRIRLACVLLETCGTYFSSGSSKRRLDYYLIFLQSYYWFKRDLWKDAFPPTLEHIFKDTLTTLRPKIKLCQSYEETQTELNNIRVTLGFDKITGDLNENKVEEDGLETIAETDTEEQDEVSEVTAPITDDTATEDETVDHTQGSDDEGEPDVSEAEQEQVSESLAIPSGPRKVECPEDEDFLNALDKMVSENIQERMREPVKAGNVDISVPVVLKSNKKTYEQLQDAPETEPNKIGFVLMVRKGNKQQYKNFEADINSELAQNLRDQELAQKEEKERVKRLTLNITERFEEEDYQDMMQQQNRPVTQNLNRERKKYQHPKGAPDADLIFGPKRVR
The following text describes a protein:
Function:
Represses mngA and mngB. Regulates its own expression.
Sequence:
MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITPQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRKSSR
The following text describes a protein:
Function:
Essential for photosystem II (PSII) biogenesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MATSSAATASLHLLLPASRRRRLLVPRATTHSNSDPTAVDRRRFIAHTAAAAAVAPLVLPRWTPTARADDAPALSEWERVFLPIDPGVVLLDIAFVPDDPSHGFLLGTRQTILETKDGGNTWFPRSIPSAEDEDFNYRFNSVSFKGKEGWIIGKPAILLHTSNAGESWERIPLSAQLPGNMVYIKATGEQSAEMVTDEGAIYVTSNRGYNWKAAVQETVSATLNRTVSSGISGASYYTGTFNTVNRSPDGRYVAVSSRGNFYLTWEPGQPFWQPHNRAVARRIQNMGWRADGGLWLLVRGGGLFLSKGTGITEDFEEVQVQSRGFGILDVGYRSQDEAWAAGGSGVLLKTTNGGKNWVRDKAADNIAANLYSVKFLDDRKGFVLGNDGVLLRYLG
The following text describes a protein:
Function:
Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones.
Subcellular Localization:
Vacuole.
Sequence:
MEKGISKEGVQFYHDLIDKLLKNDITPLVTAFHWDIPADLEDEYGGFLSERVVHGSSAVQAKKAPGRCSPYIKDFGHLCQDGRSGFEAYVVSHNLLVSHAEAVDAFRKCEKCKGGKIGIAHSPAWFEPEDVEGGQRTVDRVLDFIMGCSFYAKASEKPDYRQPSWATDSLVEFEPGLRKLVKYIKDRYGNPEIIITENGYGEDLGVKDTDHSVALNDHNRKYYHQRHLLALHQAICEDKVNVTSYFVWSLMDNFEWQDGYTARFGLYYIDFKNSLTRMEKESAKWFTEFLKPGPKQKSSKSTFSEEL
The following text describes a protein:
Function:
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
Sequence:
MSFQVPTVGVEEEYQLVDPRSGALIPNCKEVMRTIRRNGGSEEAHSEIQHELHLNQIEMASDVCSSLEEVRDALTQTRRMLIDAARSNETELASAGTNPLPIPTDDALTPKDRYQAMTDRYQQIARDLFIFGCHVHVAMEDRELGIQVMNRCRRWLPILQAITANSPYWDGVDTGYASYRRELWAQWPMAGPPAHFDSLADYQSCVDDLVACGAIKDESFLYWDIRLPTRVPTIEFRAADVMTRVEETVGYVGMIRAIVMLAISEEEQGKPIVPIRPSVLSYAIWHAARYGMNEQLVDPESREMIPASELLNRLMTAIDPALKATGEARPVEAFANQLIKSGTGADRQRRGGELSSVVANVVAETVPSAILA
The following text describes a protein:
Function:
Involved in the biosynthesis of prenylated phenolics natural products which contribute to the bitter taste of beer and display broad biological activities (Probable). Catalyzes the ligation of CoA on (E)-4-coumarate to produce (E)-4-coumaroyl-CoA.
Subcellular Localization:
Cytoplasm.
Domain:
Both substrate-binding domains (SBD1 and SBD2) are involved in the substrate recognition, and are sufficient to confer the substrate specificity.
Sequence:
MENNKQDDHQEEFIFRSKLPDIYIPNHLPLHSYCFENISQFKDRPCLINGATGEIITYADVDLTSRKVAAGLDKLGIKQGDVIMLLLQNSPEFVYAFLAASYIGAIITTANPFYTPAEVAKQAAASKTKLVITLAGYIDKVKEFTGGESGVKVMCVDAPPPESECLHFSELTQADETEIPAVKIHPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYFHQNDVILCVLPLFHIYSLNSILLCGLRVGAAILIMQKFEISKLLELIEKFKVTIAPFVPPIVLSVAKCPDLHRYDLSSIRTVMSGGAPMGKELEDAVKEKLPHAKLGQGYGMTEAGPVLSMCLAFAKEPFPIKSGACGTVVRNAEMKIVDPDTGASLPRNQSGEICIRGKQIMKGYINDAEATKGTIDEGGWLHTGDIGFIDNDDELFIVDRLKELIKYKGFQVAPAELESMLISHPNITDAAVVPMKDEAAGEVPVAFVVRSNGSKITEEDIKQYISKQVVFYKRINKAFFIEEIPKNPSGKILRKILRAKLVTEQAI
The following text describes a protein:
Function:
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Sequence:
SPSSTSSSKSRKTKANSSATVSKTKTRVKKEKGANVRKLKVHSKSERLDMAIKAFRWWNAEELPEGIQWRTLEHNGVMFPPPYQPHHVPLIYNDKEVELTPTQEEVASFYAAIPKDGPQLGNPKTAKIFNKNFFTDFKKVLGRQHDIKTFDGCDFSRIAVHLENLREEKKNMTKEEKLPEKEKREMELFTNGFAFVDGHLEKVGNFRIEPPGLFRGRGEHPKTGTLKERVMPEDVTVNVGISDRVPICNVPGHAWKQVIHRDTVSWLAYWNENVMGGIKYVFFAASSSFKGKSDLAKYDKARRLKKCIDKIRRDYTKGLRAKDMFTKQRSTAMWVIDVLALRVGNEKGEDEADTVGCCSLRVEHMSFNDETCALTLSFLGKDSMPYNNTVELAQYGDVGKQVYKNLQTFCVKKGKNEDVFHELSVTELNKHLSSLMPGLSAKVFRTFNASFTLEKELPGPSGQELDPKGKMEVAPKVVLYNDANRKVAILCNHQRTAPKSFDTTLDKMNAQLDQLKGQLKDLKQMQALIAKGKSDKIKLKSATADSKEDDALAKKAQAHLFQRAPSADQVAKKIENWKKKIKALSLRLQDKTDNKEVALGTSKLNYMDPRITVAWCKRNEVPISAVFSKTLREKFVWAMDVDPDWKF
The following text describes a protein:
Function:
Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MLQISHLYADYGGKPALEDINLTLESGELLVVLGPSGCGKTTLLNLIAGFVPYQHGSIQLAGKRIEGPGAERGVVFQNEGLLPWRNVQDNVAFGLQLAGIEKMQRLEIAHQMLKKVGLEGAEKRYIWQLSGGQRQRVGIARALAANPQLLLLDEPFGALDAFTRDQMQTLLLKLWQETGKQVLLITHDIEEAVFMATELVLLSSGPGRVLERLPLNFARRFVAGESSRSIKSDPQFIAMREYVLSRVFEQREAFS
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Sequence:
MAAVSRASTRIPHLLAARGALSLHTTAPALSSSSTASPTPYARPLPPSASSPTGLPKAAEYVISKVDDLMNWARRGSIWPMTFGLACCAVEMMHTGAARYDLDRFGVIFRPSPRQSDCMIVAGTLTNKMAPALRKVYDQMPEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALLYGILQLQKKINRRKDFLQWWTK
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEHRVVAFAAASRACVTLLALATSAIVTPYDTSSHLQVGASPLAALSNWDGVYFTHIALHGYDFEHFHAFFPLYPLLVRWLARLLPLQPASAILASGWFVSNVSFVLSALFLYRLGRVVLQDEAVARRAAYLFCVAPSSIFMSAVYSESLMCLLSFSGLYFLARHAEAPKPRRAFRDLVYCSLLFGAASATRSNGILLSSMVPYCPSLFQRFGGEVSGNASMEDRSWCAEVMPNFSAMYMFIQSEYWNVGLFRYYELKQIPNFLLAAPIIVLSLHALQGKATSGLTIYGRLVVGYFLLYTVLGSVLFPSFYPWT
The following text describes a protein:
Function:
Involved in the O- and N-linked oligosaccharide modification of proteins transported through the Golgi stack. This occurs in cis Golgi where the enzyme transfers galactose from UDP-galactose to a variety of mannose based acceptors.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRFAPYLISAVVITTIILGGAWWTSAMDTKLQTKMKEIIDQHTSTWTPVVSSVTSTQTDTLRVTISEVVSVTATLTETFTATPTVTSVVHALATTDPHPDNSKIVILMGSNFQNDANSPLHPFAQSIIKNRREYAERHGYKFEFLDADAYASRVTGHLMPWVKVPMLQDTMKKYPDAEWIWWLDHDALVMNKDLNVVDHVLKHDRLNTILTREAEYKSGAGIPADGFRTPKDQDAKDVHFIISQDFNGINAGSLFIRNSEVGRWIVDLWFEPLYLDHIQGYAEQQAFSHMVFYHPQVYKHVGVVPLKAINAYDFDDNIWGYDDGDLCIHFAGCNYFKNCPEKFLKYAQILSSKQGSDWMSAQEKDHIQNLLKPSS
The following text describes a protein:
Function:
Forms a complex with IDN2 and FDM2/IDNL2 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway. Required for de novo DNA methylation and 24 nucleotide small interfering RNA (siRNA) accumulation. Binds unmethylated but not methylated DNAs through its coiled-coil domain. May bind double-stranded RNAs (dsRNAs) with 5'-overhangs through its XS domain. However, according to , FMD1 does not bind dsRNAs.
Sequence:
MSISDEEAEISESEIEDYSETPYRLLRDGTYKVKVNGQLRCPFCAGKKKQDYKYKELYAHATGVSKGSATRSALQKANHLALAMFLENELAGYAEPVPRPPVVPPQLDETEPNPHNVYVWPWMGIVVNPLKEADDKELLLDSAYWLQTLSKFKPIEVNAFWVEQDSIVGVIAKFNGDWSGFAGATELEKEFETQGSSKKEWTERSGDSESKAYGWCARADDFESQGPIGEYLSKEGQLRTVSDISQKNVQDRNTVLEELSDMIAMTNEDLNKVQYSYNRTAMSLQRVLDEKKNLHQAFADETKKMQQMSLRHIQKILYDKEKLSNELDRKMRDLESRAKQLEKHEALTELDRQKLDEDKRKSDAMNKSLQLASREQKKADESVLRLVEEHQRQKEDALNKILLLEKQLDTKQTLEMEIQELKGKLQVMKHLGDDDDEAVQKKMKEMNDELDDKKAELEGLESMNSVLMTKERQSNDEIQAARKKLIAGLTGLLGAETDIGVKRMGELDEKPFLDVCKLRYSANEAAVEAATLCSTWQENLKNPSWQPFKHEGTGDGAEEVVDEDDEQLKKLKREWGKEVHNAVKTALVEMNEYNASGRYTTPELWNFKEGRKATLKEVITFISNDIKILKRKRT
The following text describes a protein:
Function:
Transcription activator involved in oxidative stress response and cadmium resistance. Regulates the transcription of genes overrepresented for the function of stabilizing proteins including the inducible Hsp90-family protein HSP82. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific cysteine residues resulting in the alteration of its subcellular location. Activation by alkyl hydroperoxides or cadmium induces nuclear accumulation and as a result CAD1/YAP2 transcriptional activity.
Miscellaneous:
MISCELLANEOUS: One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities; MISCELLANEOUS: Present with 623 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Oxidized CAD1/YAP2 is found predominantly in the nucleus, while reduced CAD1/YAP2 is continuously exported to the cytoplasm by CRM1/exportin 1.
Domain:
Contains a C-terminal cysteine rich domain (c-CRD), but lacks the N-terminal CRD (n-CRD) found in its paralog YAP1. It probably also contains embedded in the c-CRD a nuclear export signal, with which the nuclear export protein CRM1/exportin 1 may interact in the absence of inter- or intramolecular disulfide bonds (or otherwise oxidized/modified cysteines) within the c-CRD.
Sequence:
MGNILRKGQQIYLAGDMKKQMLLNKDGTPKRKVGRPGRKRIDSEAKSRRTAQNRAAQRAFRDRKEAKMKSLQERVELLEQKDAQNKTTTDFLLCSLKSLLSEITKYRAKNSDDERILAFLDDLQEQQKRENEKGTSTAVSKAAKELPSPNSDENMTVNTSIEVQPHTQENEKVMWNIGSWNAPSLTNSWDSPPGNRTGAVTIGDESINGSEMPDFSLDLVSNDRQTGLEALDYDIHNYFPQHSERLTAEKIDTSACQCEIDQKYLPYETEDDTLFPSVLPLAVGSQCNNICNRKCIGTKPCSNKEIKCDLITSHLLNQKSLASVLPVAASHTKTIRTQSEAIEHISSAISNGKASCYHILEEISSLPKYSSLDIDDLCSELIIKAKCTDDCKIVVKARDLQSALVRQLL