lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites. Required for the assembly of signaling-competent cilia with proper structure and length. Mediates this function in part by regulating transition zone assembly and basal body recruitment of the IFT-B complex. Cooperates with the ciliopathy proteins CSPP1 and CEP104 during cilium length regulation. Plays two important roles during cell division. First, is required for mitotic progression via regulation of spindle assembly, organization and orientation, levels of spindle microtubules (MTs), kinetochore-fiber integrity, and chromosome alignment. Second, functions during cytokinesis in part by regulating assembly and organization of central spindle and midbody MTs (By similarity). Plays a role in retina morphogenesis and/or homeostasis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Note=Restricted to the centrosomes and the spindle microtubules during mitosis (By similarity). Enriched in the inner segment of the photoreceptor.
Sequence:
MNLGDGLKLETELLDGKTKLILSPYEHKSKVSVKMGNKFKIAKCPLRTKQTGHTLKSTQNTYIGNENLSQKKISTLDTSQAKPENSRLTFSPSTDKQYSEKDSVRVQKEISPTTSNIRKIINTTGTCPVAKQKPCKKNPTAETMNSGLVCLTQDQLRQILMLSVNQGNGSVCLTETGEEEASQDSLHLINIPSQPKDVNDTGFLQNTEAASPVTSEHEHVHRRAQEAFQQCEQKAATENEWKPADIFSTLGERERDKSLLEARRAQWKKELDEQVALKKKEKEASQKWHNPWKPSDIECEKSQVHDQSKEARLLESPCSAIKQEQQRKWIEELNKQVEDDQQRKAEERMIYSKGEEHDRWAVHFDSLKSHPGSQSRLSSQLTHQHLESLCVSPDTQELADVNGVFTPPPGVQAEPSEKEQRARPVLEMAVSHGPKTNFLRSMTALLDPAQIEERERRRQKQLEHQKAIMAQVEENRRKKRLEEEQRKKEEQELELRLAREREEMQRQYEEDILKQRQREEIMTLKTNELFHTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIQNLGAQVDYKAFTTISSSHSDPEETADTSTASPKKDTGVQTDDVNLGIFNDALPPCGSVTEKGIRNISSPEISAEFSGQTDIRKENQELSMNKGTNLDKENSWHNGQCNQYRRTEKQTKLMKKCPKKPAWNINKPLKKYVPASAKYPAHLQKEKEEKKVQRQMELLHLVERNNPENLSQNRGISPLATSHRETESESRLHLIKKVEEPLKTPSVSKERFQTSPAVKNRTQQTQSNVLHLPLKNNDYEKETLTLGDGHTKLSDEMSEPSHFIPYVRTNEIYYLDPDAPLSRPSTQDNQYQKSHDCAREQELFDSDHIRDPLLNPKLVKNRDRQQAILKGLSELRQGLLQKQKELETNLIPLTANQEDNFSSSF
The following text describes a protein:
Function:
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells. Delays cell-cycle reentry of the Z2 and Z3 primordial germ cells in response to transcription-induced DNA damage as they emerge from cell cycle arrest in L1 larvae. Essential for embryogenesis.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=The Ser-344 phosphorylated form colocalizes with P granules in a perinuclear manner in embryonic germline precursor cells and in Z2/Z3 primordial germ cells in L1 stage larvae.
Sequence:
MSAASTTSTPAAAAVAPQQPESLYRVVQTLGEGAFGEVLLIVNTKNPEVAAAMKKINIANKSKDFIDNIRKEYLLQKRVSAVGHDNVIRMIGMRNDPQFYYLFLEYADGGELFDKIEPDCGMSPVFAQFYFKQLICGLKFIHDNDVVHRDIKPENLLLTGTHVLKISDFGMATLYRNKGEERLLDLSCGTIPYAAPELCAGKKYRGPPVDVWSSGIVLIAMLTGELPWDRASDASQSYMGWISNTSLDERPWKKIDVRALCMLRKIVTDKTDKRATIEQIQADPWYQHNFGQVETPNGRPLKRARNNDENITCTQQAECSAKRRHLETPNEKSTLAERQNASFSQPTKTEDLLLTQHIDMSQTNSNLLQRMVCRMTRFCVVTDIRSTYQKVARASEHAGFGVRETDDYRLLVTWREVSMMVSLYTMGDIPDKPRVMVDFRRSRGDGIQFKKMFMDVRNRMHEWICTDGNNWLANLGYVPRNPQIVNGGGVNVEHSASSINVDV
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAELGQQTVDFSTLVSRAAEESFLSLKELVDKSKSSDQSDSDKKLSLLKYLVKTQQRMLRLNVLAKWCQQVPLIQYCQQLQSTLSSHEACFTQTADSLFFLHEGLQQARAPIYDVPSAIEVLLTGSYQRLPKCIEDVGMQSTLTEEQQKPALKKLDTLVRSKLLEVTLPKEISEVKISDGTALLRVNGEFKVLVTLGYRGHLSMWRILHLELLVGERSGPVKLEELRRHALGDDLERRMAGAENPFMILYSVLHELCISLIMDTVIRQVQVLRQGRWKDAIRFELISDGSSGSTQLNQDGETDSAGLRTPGLKIVYWLDLDKNSGTSDSGTCPFIKIEPGSDLQIKCVHSTFVIDPINGREAEFSLDQSCIDVEKLLLRTICCNRYTRLLEIQKELGKNAQVFRAAGDVVLQSHMEEPDVDSKKKEIKNDGREYEGQEALLVRAYGSSFFTLGINIRTGRFLLRSSQSMLSPATLVEYEEALNQGSMTAAEVFINLRSKSILHLFASIGRFLGLEVYEQGFTIVKMPKTLLSGSTMLIMGFPDCGNLYFLHVQLDKDFKPLFKLLETQADPSAKSHSFNDSNHVMRIKKVDVSQMQIFEDELNLSLLDSGKLTGCLPAGGSSQTSEHGLLSEFSLEGPMQIAGCPPSSFSSVVDEIFEHEKGAAAPSFPLQNLTSYNASPASRFGSVPMNLHTAKAGTPSPKWEGGLQVSQMNNVVKVSNVASHYNGSLYPSNNVKGPMHSNSYSSLSSGLGRGTTVKKLSASKSDQDLASLRSPHSVEVGSSSSVDEDHLRLLNDTSMDALSGSRSSRLLSPSQSTGSRASTPGGKHSGLRSSPTGPLAGSVRGTGSSSLATTPVSQAAGDTAVFHGSGHNVSKPDKNPRKRTVSDMLNLIPSLQDTDSKAGFSKRKKTSESALSQQHSSQMLLASEMMFKNEGYSYGNLIAEANKGNAPSNIYVSALLHVVRHCSVCIKHARLTSQMDALEIPYVEEVGLRNASSNIWFRLPFARGDSCQHICLRLGRPGSMYWDVKINDQHFRDLWELQKGSSTTPWGSGVRIANTSDVDSHIRYDPEGVVLSYQSVEADSIKKLVADIRRLSNARMFALGMRKILGVRPDEKSDENSANSDVKLPAGCKSGVEATDKLSEQMRRAFKIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAGPAPGVPGVTSAIASMPKQAGYVQSQGVLGSSSANNVSQPTSVPVGNAVASSGTVPMGNISLHGSAMLAGAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKEGPKVGGSLPCPQFRPFIMEHVAQELNGLDPGFTGGQQTAGLANSNPSNPGSGSQLSGANGNRVNLPSSAVLSRAATQVAALNRVGNAVPGSSNLAVVSSGLPIRRPPGAGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQNSATSQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLTQVQGGEIAPGQKPRIELCLENHAGINENDNSENSSAAKSNIHYDRPHSCVDFALTVVLDPAHIPHVNAAGGAAWLPYCVSVRLRYSFGENTNVTFLGMEGSHGGRACWLRVDDWEKCKQRVIRTVEINGCSTGDVTQGRLKMVADSVQRTLHLCLQGLRDGSGVAASSGAA
The following text describes a protein:
Function:
Increases biofilm dispersal. Acts by binding directly to the signaling molecule cyclic-di-GMP, which decreases the intracellular concentration of cyclic-di-GMP and leads to biofilm dispersal. Also controls other biofilm-related phenotypes such as cell motility, cell size, cell aggregation and production of extracellular DNA and extracellular polysaccharides (EPS). Does not act as a phosphodiesterase.
Sequence:
MGAFTGKTVLILGGSRGIGAAIVRRFVTDGANVRFTYAGSKDAAKRLAQETGATAVFTDSADRDAVIDVVRKSGALDILVVNAGIGVFGEALELNADDIDRLFKINIHAPYHASVEAARQMPEGGRILIIGSVNGDRMPVAGMAAYAASKSALQGMARGLARDFGPRGITINVVQPGPIDTDANPANGPMRDMLHSLMAIKRHGQPEEVAGMVAWLAGPEASFVTGAMHTIDGAFGA
The following text describes a protein:
Function:
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.
Subcellular Localization:
Secreted.
Sequence:
MLTSPTARTSVRISRPATTERPNTVLTSGSLDIAMVQVVSRTLTPPTSNMKLSAALSTLAALQPAVGAAVQNRASDVADLEHYWSYGHSEPVYPTPETKGLGDWEEAFTKARSLVAQMTDKEKNNITYGYSSTANGCGGTSGGVPRLGFPGICLQDAGNGVRGTDMVNSYASGVHVGASWNRDLTYSRAQYMGAEFKRKGVNVALGPVAGPIGRIARGGRNWEGFSNDPYLSGALTGDTVRGLQESVIACVKHLIGNEQETHRSTPSMLANSRNQSSSSNLDDKTMHELYLWPFQDAVKAGAGSVMCSYNRINNSYGCQNSKAMNGLLKGELGFQGFVVSDWGAQHTGIASAAAGLDMAMPSSSYWENGTLALAVKNESLPSTRLDDMATRIVATWYKYAEIENPGHGLPYSLLAPHNLTDARDPKSKSTILQGAVEGHVLVKNTNNALPLKKPQFLSLFGYDAVAAARNTMDDLDWNMWSMGYDNSLTYPNGSAVDAMMLKYIFLSSANPSAFGPGVALNATTITGGGSGASTASYIDAPFNAFQRQAYDDDTFLAWDFASQNPLVNPASDACIVFINEQSSEGWDRPYLADPYSDTLVQNVASQCSNTMVVIHNAGVRLVDRWIENDNITAVIYAHLPGQDSGRALVEVMYGKQSPSGRLPYTVAKNESDYGSLLNPVIQSGTDDIYYPQDNFTEGVYIDYKAFVAANITPRYEFGYGLTYSTFDYSDLKVSTSSNVSTSYLAPGTTVAEGGLPSVWDIIATVTCTVSNTGSVAAAEVAQLYIGIPGGPAKVLRGFEKQLIEPGQQVQVTFDLTRRDLSTWDTEKQNWGLQAGSYALYVGKSVLDIQLTGSLSL
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MASPIQHAELEDHYVDEHLGALHGAFGKVKVMSDRKTGEKVAVKLLQRSKVTEQVEREIRHYHMLRHPCVVQLRRVLLTQFYLALVLDYVPGGSLMRFVDRKLLSEVQVRFLFQQLVAALEFCHRQGALPRSLSLDSILVGGQSFPELKLTDFGFTAIVDSLQDEHGPGITVYAAPEVLIRSQSPTAFRPFNLKAAAQTADLWSLGVILAALLFHAYPFSDPEEPKNVDRTFKRIINADYTIPEGISLSEPCKDLLSRLFKVKPEERASIADVRKHEWFLSRIPKQLRVPYEALPPADGSQSIEDIIEILDIVRSKKLLL
The following text describes a protein:
Function:
RNA-binding protein involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MAASSGSAGSTGPGGPVSFGFSRKAERRRLLAAGPCSEPENDGADTDYLTAVEDRELLSAKPAPPPPKDLVIPLRPARRWRNPEAPSSAPSSPGHAPSATNHAPLASGHALEGDPITLEIAALQELLREARQSQEHGQETPSAAPIPMRMKEDNVGSGALPTPEDYAAVPVSAFGMAMLRGMGWKKGEGIGRTFKRVVKPLEQRLRPRGLGLGAEPAPPPSSSGPPNSGGGGRREDPHSSTGGGLRVGDDVRIQSGPHRGVCGKVEALDPETARAVVRLQLGGQAVTVSQHSLTAHRAPPQRPPGAEEGSQPPPPPTPNSSTGKRRRSPEGRTAKQSRAPPHWLRRDLRVRCVDRGFRGGRFYNCKMQVEDLLSPDSCVCRTDDGRLVEGLQEAMLETVIPRGPNDRVMVVLGEHRGQAGATSFPVWPKRCYGEVISLPVFLRVAVGRRSSLPSRRYGDVVLLPVKPPGALLGRRSLTSGLSPPHFRLSHHGGPLVLFCRKSSTR
The following text describes a protein:
Function:
Acts as a component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in centromers and in several promoters.
Miscellaneous:
MISCELLANEOUS: Present with 1350 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Spindle midzone during anaphase B.
Sequence:
MRSSILFLLKLMKIMDVQQQQEAMSSEDRFQELVDSLKPRTAHQYKTYYTKYIQWCQLNQIIPTPEDNSVNSVPYKDLPISAELIHWFLLDTLITDDKPGEKREETEDLDEEEENSFKIATLKKIIGSLNFLSKLCKVHENPNANIDTKYLESVTKLHTHWIDSQKAITTNETNNTNTQVLCPPLLKVSLNLWNPETNHLSEKFFKTCSEKLRFLVDFQLRSYLNLSFEERSKIRFGSLKLGKRDRDAIIYHKVTHSAEKKDTPGHHQLLALLPQDCPFICPQTTLAAYLYLRFYGIPSVSKGDGFPNLNADENGSLLQDIPILRGKSLTTYPREETFSNYYTTVFRYCHLPYKRREYFNKCNLVYPTWDEDTFRTFFNEENHGNWLEQPEAFAFPDKIPFDFKKIMNFKSPYTSYSTNAKKDPFPPPKDLLVQIFPEIDEYKRHDYEGLSQNSRDFLDLMEVLRERFLSNLPWIYKFFPNHDIFQDPIFGNSDFQSYFNDKTIHSKGSPILSFDILPGFNKIYKNKTNFYSLLIERPSQLTFASSHNPDTHPTQKQESEGPLQMSQLDTTQLNELLKQQSFEYVQFQTLSNFQILLSVFNKIFEKLEMKKSSRGYILHQLNLFKITLDERIKKSKIDDADKFIRDNQPIKKEENIVNEDGPNTSRRTKRPKQIRLLSIADSSDESSTEDSNVFKKDGESIEDGAYGENEDENDSEMQEQLKSMINELINSKISTFLRDQMDQFELKINALLDKILEEKVTRIIEQKLGSHTGKFSTLKRPQLYMTEEHNVGFDMEVPKKLRTSGKYAETVKDNDDHQAMSTTASPSPEQDQEAKSYTDEQEFMLDKSIDSIEGIILEWFTPNAKYANQCVHSMNKSGNKSWRANCEALYKERKSIVEFYIYLVNHESLDRYKAVDICEKLRDQNEGSFSRLAKFLRKWRHDHQNSFDGLLVYLSN
The following text describes a protein:
Function:
Binds to DNA in a highly cooperative manner without pronounced sequence specificity. During synthesis of the single-stranded (progeny) viral DNA, prevents the conversion into the double-stranded replicative form. G5P is displaced by the capsid protein G8P during phage assembly on the inner bacterial membrane.
Sequence:
MIKVEIKPSQAQFTTRSGVSRQGKPYSLNEQLCYVDLGNEYPVLVKITLDEGQPAYAPGLYTVHLSSFKVGQFGSLMIDRLRLVPAK
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTTSQLHLFFKVGNVLAIMPQNNTLGKVYTILIFTLLFAGAIYSTIERNYDYFFMKNVFLYTNDVIFVCLNFYVTIIITFWKRKQWKMFWEKFNMSYKLTQTYDNRRDYPFTIFLISHVIFFAVGVYNACVWYGIEGITMIKKFGIRRMENYIHFFYSLFLTITLGMLLTRYKKLNTILNSYVTKKLRFYDSTSRKMSYIVCHLKDTVNIFNDLYGWPLFFIIYQTLLQFLIYLYFMITNEESFEVIVVQMSLISITLCMTVSLILTCSKVVQESYKLVSLTYKLRWAVTENIQKQELYEFTNLVVVNLPKFTAADFFEIDKNTILQIFATVNTLLVILIQMGQVNVTSSHRKIRE
The following text describes a protein:
Function:
May function as protective capping of the single-stranded telomeric overhang. May also participate in telomere length regulation during DNA replication. Binds specifically to the T4G4-containing extension on the 3'strand and protects this region of the telomere from nuclease digestion and chemical modification.
Miscellaneous:
MISCELLANEOUS: The sequence of MAC-41A is shown. MAC-41S differs in only one position.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MSKGASAPQQQSAFKQLYTELFNNEGDFSKVSSNLKKPLKCYVKESYPHFLVTDGYFFVAPYFTKEAVNEFHAKFPNVNIVDLTDKVIVINNWSLELRRVNSAEVFTSYANLEARLIVHSFKPNLQERLNPTRYPVNLFRDDEFKTTIQHFRHTALQAAINKTVKGDNLVDISKVADAAGKKGKVDAGIVKASASKGDEFSDFSFKEGNTATLKIADIFVQEKGKDALNKAADHTDGAKVKGGAKGKGKAAAKAAKGKKLSAKKGDSSAADVRKSVDKIVKYTPSKGSRKDTPQKSQAPAAGKSSAKKGGKKAVPSAPSPSGKKSALTTDKMTMAQFVKYLDWHEKKKGGKVSSGGKVLGKRSAGKASATSGKASKASKKTAAKK
The following text describes a protein:
Function:
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
Sequence:
MGGTFDPIHHGHLVAASEVAAQFQLDEVVFVPTGQPWQKSHRAVSAAEDRYLMTVVATVENPQFSVSRIDIDRGGPTYTVDTLRDLRALNPDADLFFITGADALAQILTWRDSEELFSLAHFIGVTRPGHTLTDAGLPKGGVSLVEVPALAISSTDCRARVAKGDPVWYLVPDGVVRYIDKRHLYRGE
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD. Can also catalyze the phosphorylation of the toxic riboflavin analogs 8-demethyl-8-aminoriboflavin (AF) to 8-demethyl-8-aminoriboflavin mononucleotide (AFMN) and roseoflavin (RoF) to roseoflavin mononucleotide (RoFMN), and the adenylation of AFMN to 8-demethyl-8-aminoriboflavin adenine dinucleotide (AFAD).
Sequence:
MKTIYLHHPITTDEWTDINKVMALGFFDGVHLGHQAVIKQAKQIAGQKGLQTAVLTFDPHPSVVLSNIRKQVKYLTPLEDKAEKMAKLGVDIMYVVRFTTQFSELSPQAFVDNYLVALHVEHVVAGFDYSYGKKGEGKMTDLAKYADGRFEVTIVDKQTAASDKISSTNIRRAITEGELEEANQLLGYPYTTKGTVIHGDKRGRTIGFPTANIRVNEDYLIPKLGVYAVKFRVNGETHLGMASIGYNITFKDDQALSIEVYILDFHREIYGEEAEIKWYQFFRPELKFNGVEGLIAQLEKDEQDTRAFFAKLED
The following text describes a protein:
Function:
Collaboratively with SUB and QKY, regulates cell growth anisotropy during gynoecium development, thus linking together cell-cell communication and cellular growth.
Subcellular Localization:
Cell membrane. Endomembrane system. Note=Localized in small cytoplasmic compartments.
Sequence:
MTTVSSAFATVAEGAKVVTPRWKKNERNGKLRVMCRYGGSIVSPPQTKSPRYVGGDTRIVAIPSSAETSFASLVSHLTVTLKISYPFKVKYQLPDQELDSLISVEADEDVQIMMEEHGYLSSESSIPQSRIRLFLFPLKSQQSNEAGASQGDSDQCKVETDIDWLGIEESNKPIREELTQPVLQHPKTEMWFVDALKSVEMMQTRRTNSGTSGSGDGNGGICGQESMMLETNSSFGSTSSSVSSSNLPPIKSSGEDNIANSQVKFAPIESVTSNDNSAVTPIPSHELPSHSHAFENKPSSNLYVAELNRPVPVPISGYPPFMNQAQQQHIQVIYTGQPYITGNSPMTLPATAYHHTNHVYYQRPPQPYPIYYIPVEQYSSRHVQALPVKPSTVLNYHQVDSPVVRTSSPLAPEFSSQVYPLSKPVDSSVQTSSEATLNTTSRDAFIYNTDVDDDNDIAHAQIYKSQPPAPTLPSQY
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MENLNLLGFLFITLNCNVTIMGMLWLIVAVLLRMLVVVLAGSPIYEDEQERFICNTLQPGCANVCYDLFSPVSPLRFWLVQSLALLLPSVVFGTYTLHRSTKLAAAAACRPQVPDLSSAYLVHLLLRMLLEAGLAFLHYFLFGFSVPAHVSCSRVPCSGAVDCYVSRPTEKSLLMLFFWAVSALSFLLSLVDLLCSLPKRTLRTTQWVKGEARAGCEVPAPSPCLLQDPQGYHSQGQVDQEARQEEQVVPEFSVWTAGQGGNSKAGQVSASGLLEHSDQDVSEVTSSAGDRLAVAQTPHEFRSYRETSPDLGSKNTRSDALSLATQSHLARHCSASQPQAPGRLTTSGSAPHLRTKKSEWV
The following text describes a protein:
Function:
Part of the Mis12c/MINDc subcomplex in the outer kinetochore which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associates with the outer kinetochore.
Sequence:
MTSRKEQLDAFLSRTLSETIAHIPLEKFAQCFPSMKKGKVIAVIHQQLIEFFEKSCKQEYANLIKERDLNKKLDMLDECIHDAEFRKLHGESEVDISNKQPQEILKAHLYSHKRELLDKLNQDLLDIDKENEGLSTQIAAEEKATEDCISRMQSLIQKLEKTVYGMNEKNLAKEAHDTLNDLLPYIQNPSSTWTNALNEQGNIER
The following text describes a protein:
Function:
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
Subcellular Localization:
Mitochondrion matrix.
Domain:
Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
Sequence:
MASKLLRAVVLGPPGSGKGTVCERIAKSFGLQHLSSGQFLRENIQAKIPVGEMQSLEKGLLVPDHVFTFLSLLPLGFPRTLGQAEALDRICELDLVISLNIPFETLKDRLSARWIHPGSGRVYNMEFNPPHVQGIDDVTGEPLIQREDDKPEAVAGRLRKYKDAAKPVIELYKNRGILHSFSGTETNKIWPYVYTLVSNRIPPIHAEEAN
The following text describes a protein:
Function:
Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Subcellular Localization:
Secreted.
Sequence:
SITQEQLEKTARTFRQVCQPKHKISDEVADAVNRGVFADTKDFKCYVSCLLDIMQVARKGKVNYEKSLKQIDTMLPDHMKPAFRAGLEACKSAAQGVKDHCEAAAILLQCFYKNNPKFVFP
The following text describes a protein:
Function:
Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.
Subcellular Localization:
Nucleus.
Sequence:
MEKEATFSSTGLLQVPFGHVIGSEKWRGSQLAQEMQGKIKLIFEEGLAPVDFHLSNRFCILYITEADLVAGNNYKKRIVQLRNASNLQGIIIVEKTQMSEQYFTTVQKFVVLELGMTLLPVSNQMEASQLIIQLVHEQTKERNRNPFLKKKSCQLCESSVLQTVQQIPGVGKVMALLLLQEFPSIQKLSNASIQELERVVGHTLAEKMHTFFTQIR
The following text describes a protein:
Function:
Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM (By similarity). Binds to the DYNLL1 promoter and activates its transcription.
Subcellular Localization:
Nucleus. Note=Nuclear, in discrete foci during G1 phase.
Sequence:
MAATEAAAADSAGPAPGVPATPASTRGAAAASSPWRPPESRLQGSRPRPARARAAAPVPPARELIQPTVSELSRAVRTNILCTVRGCGKILPNSPALNMHLVKSHRLQDGIVNPTIRKDLTTAPKFYCCPIKGCPRGPDRPFSQFSLVKQHFMKMHAEKKHKCSKCSNSYGTEWDLKRHEEDCGKTFQCTCGCPYASRTALQSHIYRTGHEIPAEHRDPPSKKRKMESYLQNQKLSSKTTEPLSDQAAPRQDAAEPDAPEVKPAASLEDSCSAHTKKQSVATPPRCPQKLLLPKPKVALVKLPVMQFSPVPVFVPTAESSAQPVVLGVDHSSAAGTVHLVPLSVGALILSLDSEACSLKESLPLSKIISPVVEPMNTGVQVNLGKSLCSPLQEVGSVCQRTSISSSNVQTDLTYASANLIPSAQWLGPDSSVSSCSQTDLSFDSQVSLPVSVHTQTLVPSSKVTSSIAAQTDAFIDACFQPGGVSRETQTSRMQNRTNDSVPVGHTGLCGDIFESVHASYSVPTDTIMSSSLVAETGTHGLPPQSDPKILGQVMEKSAPVLNFSTQNGLLPAHTMTDNQTQTIDLLSDLENILSSNLPGQTLDNRSLLSDTNPGPDAQLPAGSAQNSGIDFDIEEFLSASNIQTQTEESELSSMSTEPVLESLDIETQTDVLLSDPSTQPYGFRAGSGFLGLEMFDTQTQTDLNFFLDSSPHLPLGSILKHSSFSMSTDSSDTETQTEGACPARHLPALESKVQLSSTETQTMSSGFEPLGNLFLTSNETQTAMDDFLLADLAWNTMESQFSSVETQTCAELHAVSSF
The following text describes a protein:
Function:
Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDIQTLRSEIKAWERAYADKHGRKPTPKEVKADPIAKKYHLYNKFKKAESAGTGPSTPKRASKLHSSLNYKPVSFSVKTPEKQISKNRRRSVSKQQHADIVTPSHRSLTFSKAPALSRTPQKQLQDTPKAATPKPSPSVPLGPTPSIHGRVVSLLEGLDGTPVKEFATPGNVSTPVKVVSITSETPTNKPALDVNDEFTTPAYLNRISVDVSPFEKRLSFAERIRQSVVESPIKQMSPEKELSPANQTEEYDDDEDAWRELEGLPPKPKEPKIVDVTFDGEEPDELDEIMGTVEVHNPYDEPVQDDLDWVHETALEGETALSAPIYKEGGIKKRKHQTQKRTTKKAIVRVESEQHKKAKVDNDNFSTTNRLNTGFKVNMGQKQWASRFKK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes.
Subcellular Localization:
Nucleus.
Sequence:
MKENNKILQLIYVAWRERWTDSQWGINIKKVLPRGVSGDVYNLADCLMQQALIGSTANPLVLNYLKHSLCAHLVSHAAVIRCIAKYDKLERVYCITALLEFLASIVDGVTCRIKSEEAVLPSSVVHLVYWLLQIFARTVQHYELYGEISAEQSYMLDQTCVVIDRLSQQQFLLSMLYVGCHEELEICGRIRDKYATIKGSLTNSNFTLNAPQVEQQLQQLAFIEAKHLEMQPLNPPSTLEKISCCVQPLLAVEVLLNPCKDTSYYVAELQMLQRLKKYSNTRLFYEIIRAGFLTLSNVADTSPDTMWGAFMFFKMPHIIKQLHALQRIPGEQPPPADYIPELVEALELLIEDNLLLDFMDTKCSCNMIEFLLNDWTKQQLVNDVHVKKFASQREAASQLLKKCDNGQQTPSNINFIKRAEVPLSGVLKTLCTNKVQDMVNVLCQVPVGNSFELILSVATVEGRLKTFVSRLIQCNENSKPVPGDLGKLCVIRSTLFDVSFLMLTSIVQTYGSDVVLSERGDSFFEKWVRECMVERNKLKNPRQILALCDDSIVDELLLSFSKPEASQLKPNNLSWQETCLNLPGVLHHVLIAWEQETLSSADVKSILDNIKRRLFSFSVCATSFLCAYMYSVKETELLKPLNMIQQFLAPLTSEELSSQENAKERLALSYQIIRKMQHDVHPAPSTKSRLISHSPLVEQFREVWRTVVDAGHLPVRAAQSLESLLLAGGAAWLSTQLVEQLLACKYTRDMSRTMDVVFAVMHLDIEKTTEALLQYVVAPLILRRQGEDINEPQSLVLARLCVYCIISCLESRKGNGTSALTAMKKRSRSHDDEELAANAAKVRKVIGDGSDNSSDFTDTTTGAGLAALLGSTSTSELRTTPLTLREPLQTSVQHIFAVFLQFVSGDELSPKAVFVYQFISLLVECGGERVAPVLRLLPNGLVQQLLKVLVTDDIKVGLISRLYDLRIQAGRLSAVSDLCLWRNMQMARHSIHL
The following text describes a protein:
Function:
Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart. Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes. Thereby contributes to oocyte survival and the resumption and completion of meiosis.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Core component of cytoplasmic lattices in oocytes. In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions. Expression largely disappears in blastocysts.
Domain:
Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA.
Sequence:
MASHTADADAKPDSDSQKLLNVLPVSLRLRTRPWWFPIQEVSNPLVLYMEAWVAERVIGTDQAEISEIEWMCQALLTVDSVNSGNLAEITIFGQPSAQTRMKNILLNMAAWHKENELQRAVKVKEVEEFLKIRASSILSKLSKKGLKLAGFPLPLEGRETQMES
The following text describes a protein:
Function:
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASVAAAGPPAVKIGIIGGTGLDDPEILEGRTEKIVETPYGKPSDALILGKIKNVDCVLLARHGRQHTIMPSAVNFQANIWALKEEGCTHIIVTTACGSLREEIQPGDIVLIDQFIDRTTKRKQTFYDGSHRCSEGVCHIPMAEPFCPKTREVLIEIAKKLGLKCHPKGTVVTIEGPRFSSRAESLMFRNWGADVINMTTVPEVILAKEVGICYASIAMATDYDCWKEHEEAVSVDKVMKILKENANKATSLLLIAIPQIGSLEWTETIQNIQNVAQFSVLAPRH