lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Recruited co-dependently with zhp-4 to the synaptonemal complex between homologous chromosome pairs to regulate the formation and number of crossover events between homologs during meiotic recombination. In the early stages of pachytene, in complex with zhp-4, recruited by the zhp-1-zhp-2 heterodimer to designated crossover sites along the homolog pair to stabilize other pro-crossover factors such as rmh-1, msh-5 and cosa-1. This in turn facilitates crossover and promotes the formation of chiasma in each meiotic nucleus at the late pachytene stage of meiosis. Plays a role in the segregation of homologous chromosomes following the completion of crossovers. Together with him-14 and msh-5 plays a role in the activation of DNA damage-dependent apoptosis at the DNA damage checkpoint in pachytene cells.
Subcellular Localization:
Chromosome. Note=Co-localizes with zhp-4 to chromosomes from mitosis to early diakinesis in the germline. Co-localizes with syp-1, a component of the synaptonemal complex, throughout the gonad from early prophase to mid-pachytene. In early pachytene, co-localizes with syp-1 as puncta along chromosomes. In pachytene nuclei, localizes in linear arrays in the space in between synapsed chromosomes. Does not localize to unsynapsed chromosomes. From mid-pachytene, co-localizes with cosa-1 at crossover sites of recombination intermediates, and gradually disassociates from syp-1 along both chromosome arms. Co-localizes with brc-1 at crossover sites in mid-late pachytene nuclei. At late pachytene, localizes asymmetrically on synapsed chromosomes. At late pachytene and early diplotene localizes to a single focus at the boundary between the long and short arm of each pair of homologous chromosomes. At late pachytene, localization at chromosomes is not dependent on syp-1. In diakinesis, does not localize to chromosomes, but is dispersed between chromosomes.
Sequence:
MDFVHCNKCFNRKPPDGFFISSCFHIFCTKCAKADLAVCLICKKNVRLVRLDGNISSGIKIYFADPIKMVADSLAKIQKKIDFQQSTRDHLVKYLTKEKEKKRQMEVYFRTKGQEFDSQRKKLAEATAWIQMAEKKLQASEEERVKAEREIEECQAKLKSMTNLMSADTLGMNSQTPFPFSLAESQETAPSLVESSANSTFNMVSPLVSSPASSPNSINYNSFFENGSRTRPESLNEEAMFNTMLQSSGQSANANTSESSAFSVAFNNIFTPSRNNMGDSSMINKTTANQTIMDKTSMSLENWRQNRANSFGVHDISKRDSSLPTGGGSAIRVHHFKQNSRITPIAQNRRSAAGFDRQQIQEMRRISSQPGYLAQRKPINGRSFIGPAD
The following text describes a protein:
Function:
Protein kinase that acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylating and inhibiting the mitosis-promoting cyclin B-bound CDC28 at 'Tyr-18'. SWE1-mediated inhibition of CDC28 acts in a cell size or morphogenesis checkpoint to delay mitosis in response to defects in growth, actin organization or bud formation. Plays an important role in filamentous growth.
Subcellular Localization:
Bud neck. Nucleus.
Sequence:
MDSNPCQDVSGDTSSTPMANNNPTNDSTISSQNHSKIGLRKHQQQHYHQHSHSQMHSHSQQSPYINQLEYFTNNQFSRSFNSLILEDANDANTNNSSTTTLNKKTINKSPPFNIKQDLLNDSIDTFLDNSNTETIEDGDVTTTDDDHDFDDEDIEDPEAVQYTPTLNILKSKKVDSFDIISSKHRKSNSQITYNSHVRKPSEEDTSSSMATIRLSNNSQSSIKRSSKYLNLSIDSNLKTVDGGKIPDEIDDISLNEIDVAVAPNDFSSPLSARKPDIFAAITAANGNSNNQFKRPHKLVSQSPSPSSKNKFRISSSTTSSPQSNLHSPSKLGSKGFKMFKNANRDAIMSSSRVMTPEKPKMVSKIFGKSAKIRRAYTPTHTSTPMAVSSLNPPSSSTSNSTTAAITSTSPPANEHYDIDNDFDSPSKNRKSSNISASSIIIYQDENHIKSNHARKSSNPIPYPPTEPLPTNISASVAETGKGSTTTKSNLSKGCPLFDDKENKASYQFVKPLQTAFNSSGLVKKNSISGSSDRKLPPETPIKRNPLMILNTNKVVPPYSSGFAEGKDVMGDQHDIYSHIPCQNQRFPGSVNPNTTTNNNNTQQHHDSDLSIEVGRNNSYDASSSTINNTSYIKIFPSSELKKEQVLQRPQEDLELVFNSDIELDDNIIPETPTKKSLLPNQHHQHHLPLYTQSKSPLLKFDTEKDGRRNLSIVLDKSNATKREISEPPSTPINMSFAKNSFKKPMNNAERGDDPDSIIAQRIDIMPSLDEADSVSVYPSKIDEHLIEKFGMKNIKYIGSGAFSIAFECLFNNEKFAIKRTKKPLIGKLEKQTIKREIEALRVLTSIKEDEATNMQEQEEGKEYLVYFIEAWDFNNYYYIMTEFCEGGTLFDFLEENKHYKIDEFRIWKILIEILNGLKFIHSKNYLHLDLKPANIFITFEGSLKIGDFGLATKLPILEKDFDLEGDRNYIAPELINDKIYTPFADIFSLGLIILEIAANIILPDNGTPWRKLRSGDLSDAGRLSSDNISMFLQHNPNTNSNISGSGSRSGSGSTGGNGSAGDGSTNSTNFSYNSLSGNSLTLNPPVKAVHGTSDTNNTLASELSKNIEGLIPSWAPDFLVHGDSMNLDKLVNKMLRPNPFDRPSACNILEMPECLIVENRRKCGATIFEGEFGSPPDE
The following text describes a protein:
Function:
RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKNRKSKRQLVRDEKRAKKREREIEHEEERDIKKQRREEAQQEALAPAAADYVPPPLDGTYDENAFSSAPEGRRGPNTNFEREFFGMLAEEEQEYFRHADELLELNDFPSAEERDIFLQNVYKEMRGKELKLASSQSCSRLMERLILLSNTRQKKSLFDAFGGHFISLVTHRFASHCCEKLFLQSAPVVTQELSGEYEQEPLPEGEEETEAMKSSMEDLFLLTLDELEEHLGFLLSDRYGSHAMRALLVILSGRPLDQAGTKSLLQSRKKEYITVEGAAANASELSSQIRAVPSSFTMAIKKIIDDSTATMDATALRVLAKHPTGNPTLQLLLELELTMFGKNKEKKDKKQKKDDDEAETKKEETQSEISLLGMLVPDAPAAFADNTTQAAEFVNSMIYDPIGSRLLETLITHCPGKIFKGLQQHIFGPRIQSLLRNDIACYPAIRVLNRLSREDLADAVEKSLPEMASFVDKGRFNVIKTLFERCNVRNGTDEINSLLKALTSAYGNDWKNIVPKLCMLDEEVSEEEQKPESTEEVGEEEAEEKKKQQQPKFQTQEAKNKAFMLNHGSQLVAALLTIPGQPSKAIQSSLAALKPAQVMKMATTSHNTSSILIKALQTPAITPTFHKVLVSSLLPHVYELATSQHGSAILNAIITLPSKPAEPNAPAVPFHMKENIISQLAQYERDLRETWLGRNVWRTWKGDLWSHRRHDWVRWAKETDPETARVAAAPKKREEKEKEEAEKKPKGYLGKNFDPKKAKGLAGNKKFEKKEVSA
The following text describes a protein:
Function:
Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
Sequence:
ILKFKVLVLMDFVGNLDDELVIKAGDIIKNVKQSMEEGWLEGELNGKQGVFPANFAKEIPVYLTGDSQRIPRSIRTSKTVKKKPTKYEAVFAYTPMNLDELELTVGDVIDFIKEIEDGWWLGAKNGKAGAFPSNFVKEVSPKDAKLNETNSGAKIRPKLSECNFNKEPKQEKSSLRVKHKTNNVKECCQVMFDYTANAEDELTLKKGEIVTIISKTTEDEGWWEGEINGKHGFFPDNFVMAIPTQPLEQSGDANHPPVRKGSRKASVKQEALLMEKKIFEQAHPIPCAKEEKHETKDLRSDPPSKVQLPVIKKVPPPIKTKPPKNLPIRQNGDLPPLSPKHAEDTKPDQFDGVDVTTDKLSHPTANRAKLPGRRPPTNLHWGATAQKPVPSTSETNDEVSQLQSKLPGVHKVIENPTAGKPDPLAKISPLQKPVPSKPREEPGASVEKLRAEVKELSLALEILKALHLKDTEDLRQELKDEKAKRTALQDEVQLLKKAF
The following text describes a protein:
Function:
Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Lipid droplet. Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MQYSCDHNSEPGVAGSSQSAKPRHQHVASSSCTWHQHIFVPYIPLSLSGPAIATALAYLNAKYSIFYDVTLIKALLKIAVKNSLAQRRDRLNLFYVLESHALSPATKDQTFIVYDGRTWSFHETYELALRYGNWFKTVHNVKPKEIVAVDFMNSSTFIFLLLGLWSIGAVPAFINYNLTGKPLTHSVRTSTARLLIVDDEVRNCFPPEQLEIFASSDFREDKGAVEVVFFTPDVEAQVMQTEAVREDDKARSGPVLRDMAMLIYTSGTTGLPKPAIVSWRKCWTGSTFVSNWLGLKPADRFFTCMPLYHSSATILGFMSCLMSASTFVIGHKFSARSFWKEARENNATIVQYVGETLRYLLAVPPQIDPVTGEDLDKKHSVRAIFGNGLRPDIWNRVKERFNVPTIAEFYAATEGTSGSWNLSSNDFTAGAIGRNGALTKLILGASLAVVEVDHESQEPWRDPKTGLCRKVPHGQPGELLYAIDPNDPSDKFQGYFQNSKATESKIIRDVLRKGDAFFRTGDMVRWDLEGRWYFSDRLGDTFRWKSENVSTSEVAEVLGAHPDVHEANVYGVALPNHDGRAGCAAIVFQQQLQAANPSELAAPSQNVLDSLAAHVLKNLPRFAAPLFLRVTPEMQATGNNKQQKHVLRTEGVDPALVSGKDKLYWLQGNTYVPFEQKDWNRLHSGQVKL
The following text describes a protein:
Function:
Plays a role in mitochondrial morphogenesis.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAAWGRRRLGPGSGGGGARERVSLSATDCYIVHEIYNGENAQDQFEYELEQALEAQYKYIVIEPTRIGDETARWITVGNCLHKTTVLAGTACLFTPLALPLDYSHYISLPAGVLSLACCTLYGISWQFDPCCKYQVEYDAYRLSRLPLHTLTSSTPVVLVRKDDLHRKRLHNTIALAALVYCVKKIYELCAV
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MSTHSFCPACGNLLLVDTSGDRTQLKCRACNFVMGFVGRTVQSAPLNPLDVKALITNDDAMSFQNKTQARCDKCGHNEAFFTEIQIRSADEPATLFFKCCKCGNTWREG
The following text describes a protein:
Function:
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Sequence:
MKMGLKRAKTHQKAQQIKELLLKHYPNQTTELRHKNPYELLVATILSAQCTDARVNQITPKLFEKYPSVNDLALASLEEVKEIIKSVSYFNNKSKHLISMAQKVVRDFKGVIPSTQKELMSLDGVGQKTANVVLSVCFDANCIAVDTHVFRATHRLGLSNAKDPIKTEEELSDLFKDNLSKLHHALILFGRYTCKAKNPLCGACFLKEFCVSKASFKA
The following text describes a protein:
Function:
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of p53/TP53. The negative regulation of p53/TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway; The TEK-boxes are required for 'Lys-11'-linked ubiquitination and facilitate the transfer of the first ubiquitin and ubiquitin chain nucleation. TEK-boxes may direct a catalytically competent orientation of the UBE2C/UBCH10-ubiquitin thioester with the acceptor lysine residue (By similarity).
Sequence:
MATLIFVDKDNEEPGRRLASKDGLKLGTGVKALDGKLQVSTPRVGKVFNAPAVPKASRKALGTVNRVAEKPMKTGKPLQPKQPTLTGKKITEKSTKTQSSVPAPDDAYPEIEKFFPFNPLDFESFDLPEEHQISLLPLNGVPLMTLNEERGLEKLLHLGPPSPLKTPFLSWESDPLYSPPSALSTLDVELPPVCYDADI
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MASTKVQRIMTQPINLIFRFLQSKARIQIWLFEQKDLRIEGRIIGFDEYMNLVLDEAEEVSVKKKSRKPLGRILLKGDNITLMMNTYVNSFSFSLSPPLITQTNGCSPTEFSFRSSYLLHKLNFLLQIHSILSCTNINTLISGENEVVLACAWVTVLLACDLGYHAAYVNACCWVLPFQCLLLF
The following text describes a protein:
Function:
Glycosyltransferase involved in the xylosylation of xylan, the major hemicellulose (non-cellulosic component) of primary and secondary walls of angiosperms. Possesses beta-1,2-xylosyltransferase activity, transferring xylose from UDP-xylose to the xylan backbone.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MTSTAYSRPSKLPGGGNGSDRRLPPRLMRGLTTKIEPKKLGVGLLAGCCLALLTYVSLAKLFAIYSPVFASTANTSALMQNSPPSSPETGPIPPQETAAGAGNNDSTVDPVDLPEDKSLVEAQPQEPGFPSAESQEPGLPAALSRKEDDAERAAAAAASEIKQSEKKNGVAAGGDTKIKCDENGVDEGFPYARPSVCELYGDVRVSPKQKTIYVVNPSGAGGFDENGEKRLRPYARKDDFLLPGVVEVTIKSVPSEAAAPKCTKQHAVPAVVFSVAGYTDNFFHDMTDAMIPLFLTTAHLKGEVQILITNYKPWWVQKYTPLLRKLSNYDVINFDEDAGVHCFPQGYLGLYRDRDLIISPHPTRNPRNYTMVDYNRFLRDALELRRDRPSVLGEEPGMRPRMLIISRAGTRKLLNLEEVAAAATELGFNVTVAEAGADVPAFAALVNSADVLLAVHGAGLTNQIFLPAEAVVVQIVPWGNMDWMATNFYGQPARDMQLRYVEYYVGEEETSLKHNYSRDHMVFKDPKALHAQGWQTLAATIMKQDVEVNLTRFRPILLQALDRLQQ
The following text describes a protein:
Function:
Involved in peroxisome biosynthesis.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MENFQFEDLSPNKVSKVYQDLKKFGSFLYNHKMGVFLVSFSSGVAYLYHNITQSHKRKQIKLAKERVMTYFESTQKLSEREVDAIITKFIDENKILDKIQTPSLASIRSEKDPSEKLKLTDQLKVSIITKLFSVLYIIPMVTIFNRLQINLIGKYCYLDYVLYKDQEQHSMRLINQQTESNFINSRNNCYFFKDINFSQFINLIQEQIKISLKDWKIDQQSSFEGFLKLLINIRNNFEKKEIIASISSDNSLLKYLIPTEEEIDNLVQSQKTPENDNDIEYQNLKMLYNEIRNIFESQKFYDVLKDSINQSFLEFTKNLREDFESTELKKQIDSIVLPDLPIEMEIPKPLVTMHNIILLPKINKQIGNIIVNKKSIIEKIGSTDLINQLNYSVLTNDLDFNKVQF
The following text describes a protein:
Function:
Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MIRNSGRILFNSLKNSNVKLINRNVIINSNIRLFSTSTNNTIKESVEKKAETISNKDNIASPSSKSIDVSDLAGNADYNFVFERIKTCDKENYINSLLISDPIARRVAYAIRAFNIETVANDHSPKSEKISRLRLSFWKDAINNIYNGKVYDQPLTRVLAQVIKEKKLTKTWFIKILNRREKDNQQVQIKDMEELEQYADDIHSSLMLLTLEGLGVKGNHDVEHCASHLGKAIGIMVLIRGTVYHLASRKTYIPVSLTTKYGINVESLYRGDPQIEKLQNAIYEMASCAKLHLDKAKQFRGKIPHPATEAFLSVSVVEDFLERLRKADFNIFEFPNTQQHPLLLIKLYKNKFFKQF
The following text describes a protein:
Function:
Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
Subcellular Localization:
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMTAYFGKISEENIKNNFVLIYELLDEILDFGYPQNSETGALKTFITQQGIKGQFQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIDKQGKGGATDDAAKSDLGGGSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEYELMRYRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFESKLNYSDHDVIKWVRYIGRSGIYETRC
The following text describes a protein:
Function:
Provides adhesiveness to the mussel's foot. Mussels produce one of the strongest water insoluble glues. The mussel's adhesive is a bundle of threads, called a byssus, formed by a fibrous collagenous core coated with adhesive proteins (By similarity).
Miscellaneous:
MISCELLANEOUS: The identity of the hexosyl group at the C-2 position in the modified tryptophan residues has not been confirmed, but UV absorbance data suggests that it is mannose; MISCELLANEOUS: On the 2D-gel the molecular weight of this protein is: 89 kDa.
Subcellular Localization:
Secreted.
Domain:
Almost exclusively composed of repeats of the decapeptides APPPAWTAWK and ATPKPWTAWK.
Sequence:
MARNMNILTLFAVLIGSASAVYHPPSWTAWIAPKPWTAWKVHPPAWTAWKAHPPAWTAWKATPKPWTAWKAPPPAWTAWKATPKPWTAWKAPPPTWTAWKATPKPWTAWKAPPPAWTAWKATLKPWTAWKATPKPWTAWKATPKPWTAWKATPKPWTAWKATPKPWTAWKATPKPWTVWKATPKPWTAWKATPKPWTAWKAPPPAWSAWKATPKPWTVWKATPKPWTAWKATPKPWTAWKATPKPWTVWKATPKPWTAWKAPPPAWTAWKATPKPWTAWKAPPPTWTAWKATPKPWTAWKAPPPAWSAWKATPKPWTAWKATPKPWTAWKATPKPWTAWKATPKPWTAWKVPPPAWTAWKAHPPAWTAWKATPKPWTAWKAPPPAWTAWKATPKPWTAWKAPPPAWTAWKATPKPWTAWKATPKPWTVWKATPKPWTAWRATPPPTWTAWHGHGYGGYGKPGKPGKPGSKGPRGPAGPPGATGKTGRTGATGKRGPPGYPGKPGVPGRNGYVHIVFDGYGKWEIGKIERKNIREAVAKAWTAWNAGHGHGWTAWTAPPAYG
The following text describes a protein:
Function:
Has an integral role during the infection of macrophages in the mammalian host.
Subcellular Localization:
Membrane.
Sequence:
MTQLLGTAIFWCIFAAFVSHHLRAHVHVEASATHLEAPEEQWGEEGTGDTPRGWCGSHHSAINPDDVPIVGTMPPESEAKGTTGGDLISARTASVDKKPKYTNNVDDYGQGEIDSRWKPIRIRAYTQDLNDPSRFCTMAGDVRSILVSGKTTVCTAGDVLTVRKKRVIVQVAIPKAIKLHTDRLLVRRYHRRIVLPSSYAGYCSLFKVPKGHYTNGFEGDVSIYVAARPTIGNMAWASVCAMLTDGRPVSGVVNISPKYVAETDFFVRVIAHELGHALGFQADILIRRGIMKQKGGIRGLKTSWLVDSEVAKRVARKHFNCSTAPGIEMENEGGPGVFATHLEQRNAVEDVMAPYGNLNYLTVMSLGVFASMGHYRVNFSRAEKTRWGLNRGCSFLQEKCLQEGKSKHPDTFCDHLWKSRLFTCTHDRLGLGQCSLGTHRTELPAEFRYFRNSRVGGKSRFMDHCPMVVQYNSGNCVNGQSKFLRGSEVGKGSRCVKGVNLKFSNKDIGDVCVRTNCTGKELQIRFLLDHSWQTCKPGATVQPLGRHLWKGSIICPTREEVCFDDEDYKLRLTPLPKLPTDDNAAVNPRQM
The following text describes a protein:
Function:
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
Sequence:
MMDVKLKIQQLVNLIKNYDYHYYVLSEPLIDDFEYDMLYKSLQQLEKDHPDLIQIDSPTQRVGGEAVKGFKKLNHNSPMLSLENAFSTKEIANFIDNINFQTNSKNEFVVEPKIDGVSISLTYKNGVLVHALTRGDGSVGEDVLNNVKTIKSIPLTIPFTKTIEIRGEIFVDKKTFLAINNQLEKPFANARNLAAGTIRNLNSEITAQRKLRALFYYIPNGLEESITTQTMVLEQLKQWKFPVSDTIRVFQNKFQLINYLEAFDKKREQLTFNLDGLVIKLNSLLFYQQLGATSKSPRWAIAFKFSPKFVQTKLTAVLITIGRTGRVNYTAKLESVNLDGTKVTAATLHNFDYIKTKDIRINDTVVIYKAGEIIPKVLKVNLEKRKNDTIIIQEQKYCPSCNSKLVKIVDEVDQYCTNETCKERNIQLINYFVSKTAMDINGLNINTITKLYEHNLVRSIVDLYDLKDKKNQVLKLDLKIGDKLFNKLVDNIENSKQKGMARLLTGLGIKHVGNVLAKNLANHFKNIKALQHASLENLISLNDVGITVAESLYNWFHDPNHLQLIEQLELRQVKTDQLPLKINFETNSIYFQKRFLITGSFNISRDQIKDLLSAKFDCQFASEVKPTVDFVIAGNKPTLRKINHAKELNIPIINEAIWT
The following text describes a protein:
Function:
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
Subcellular Localization:
Cytoplasm.
Sequence:
MIPRVFIYRLPQDDPRKNTAIKLVRFGFAQLVDSIKALPSGSIILDPTVKTPLTPSDRVIAESRGLSLIDCSWKRAVDVHTKFIRGKFIRRRLPLLIAANPTHYGKPYILSTIEAVAAALYIMGFKDEAMEVLRLYKWGPNFIIINQKYLERYAAGDLSPERELLGVDDVDNGLEQLMRVLTNGD
The following text describes a protein:
Function:
May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Domain:
There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding; The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
Sequence:
MLLLWRRKTVGLICLFSILLTIYLYVSMYPEDNERVWNSGNADIQRKHEKLNNGGQGRHDFDDDEGAEKDEEDAVEKQNIAAPPLPKSFTTFPDRSKEIEIDTDLLGKINGKAEDDLQVEGYKKYQFNGLLSDRIGSRRKIKDSRNARCSSLTYSDSLPAASIVVCYFNESPSVLIRMVNSIFDRTKPEHLHEILLVDDSSEWSNATDEAIKYREKHIIQWEKVKFLKTDKNEGLIRAKIFGARRANGEVLVFLDSHCEVNEEWLPPLLDQIKQNRRRVVCPIIDIIDAITMKYVESPVCTGGVNWAMTFKWDYPHRSYFEDPMNYVNPLKSPTMAGGLFAIDKEYFFEIGSYDEGMDVWGAENVEISVRIWTCGGELLIMPCSRVGHIFRRQRPYGIKTDSMGKNSVRLARVWLDEYLENFFEARPNYRTFTDYGDLTSRISLRRNLQCKPFKWYLENIYPELLPDNTPNQLNNQILVAGKKYLIKMANGTHCLSAENSQGRIANGNRVEMRKCNHMERMQQWKYSSTNELRPMGSSRMCLDSLRGISVILCHNQGAHQMWQVSNAGKLYSRSVNKCATGSNDVSALSTLKFCSLANSFQFVEL
The following text describes a protein:
Function:
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
Sequence:
MLQPKRTKYRKPHNVSYEGHTKGNGYVAFGEYGIVATKGNWIDARAIESARVAISKCLGKTGKMWIRIFPHMSKTKKPLEVRMGSGKGNPEFWVAVVKKGTVMFEVANIPEQQMIKALTRAGHKLPVTWKLMKREENS
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
Sequence:
MDSLGGGLTGAQKDELMDQVKQQIAVANAQELLTKMTEKCFKKCINKPGTSLDSSEQKCVAMCMDRYMDSWNLVSKAYSLRIQRERNNM
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of inositol 1-phosphate (I-1-P) to yield free myo-inositol, a key metabolite in mycobacteria. Is also able to hydrolyze a variety of polyol phosphates such as glucitol-6-phosphate, inositol 2-phosphate (I-2-P), glycerol-2-phosphate, and 2'-AMP, albeit with reduced efficiency.
Sequence:
MTRPDNEPARLRSVAENLAAEAAAFVRGRRAEVFGISRAGDGDGAVRAKSSPTDPVTVVDTDTERLLRDRLAQLRPGDPILGEEGGGPADVTATPSDRVTWVLDPIDGTVNFVYGIPAYAVSIGAQVGGITVAGAVADVAARTVYSAATGLGAHLTDERGRHVLRCTGVDELSMALLGTGFGYSVRCREKQAELLAHVVPLVRDVRRIGSAALDLCMVAAGRLDAYYEHGVQVWDCAAGALIAAEAGARVLLSTPRAGGAGLVVVAAAPGIADELLAALQRFNGLEPIPD
The following text describes a protein:
Function:
Hydrolyzes UDP and GDP but not any other nucleoside di-, mono- or triphosphates. May promote reglycosylation reactions involved in glycoproteins folding and quality control in the endoplasmic reticulum.
Subcellular Localization:
Endomembrane system; Single-pass type II membrane protein.
Sequence:
MLFPAFSILLISFFSLLSVVTTKTQYWCHGDGVLNNQHTCRFFTIVIDAGSTGTRLHLYKFIHDPAIASHGMPFKVEKEIFQEVKPGLSSFAKSPSSAADSLEPLLQRARKEVPHFMWEKTPITLKATAGLRLLPGDMADDILESVEERIFNSGFFAAFPDAVNVMPGSDEGVYSWFTLNILLETLFTDEPTVGHKPAAHRSVAAFDLGGGSTQLTYWPNNEAVFSEHVGYERDIDFFGHHIRLFTHSFLGNGLIAARLNILQLETDNEIESTHQLITSCMPEGYQLTEWEYALKFWNINGSSSHSFESCYGTTKNFVESSEIMHLRELKGSPVYLFSYFFDRALNSGLVKGNEGGKIELRQFKEAAEIACRREKTEIDDGSHWMPWQCLDLTYIYSLLRDGYQFEDNQPLVLAKKIKGMEVSWGQGLAFATANEFQLTEGAIKTALSSEPNSTVVDQIFDLVYSGTNQVLSYFNIISV
The following text describes a protein:
Function:
Severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MVGGALAGLQDHVKLAREYAVEGLYDTSVIFFDGAIAQINKHLNTLDDPLIRSKWMNVKKAISEETEVVKQLDAEKRAFKEVPMGGRRPNSPPISTKSSSFVFQPLDEYPTSSGAPMDDPDVWRPPSRDTSRRSARAGPGGMRKGPQDGAWARGSTKTGTTGRGGRTTGSTKATSAVRSSTTGRKGPGKSTKTDSTDGDAEEGKSKKGQYEGPDADLAAMLERDVLDSTPGVRWDDVAGLSEAKRLLEEAVVLPLWMPDYFQGIRRPWKGVLMFGPPGTGKTLLAKAVATECGTTFFNVSSATLASKWRGESERMVRCLFDLARAYAPSTIFIDEIDSLCNARGGSGEHESSRRVKSELLVQVDGVSNSSTNEDGTRKIVMVLAATNFPWDIDEALRRRLEKRIYIPLPSFESRKELIRINLKSIEVAPDVDIEEVARKTEGYSGDDLTNVCRDASMNGMRRMIAGKTREEIKNMSKDEIAKDPVAMCDFVEAISKVQPSVSAADIEKHEKWFSEFGSA