lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
Sequence:
MEEEQMYDVEGGPGPGDVICMEFCYEVIHKVGGIETVVRTKAPAMVNEYGDNYFMVGPHLSWDDKFATNFEEAERNEESEILYKLIDSFEARYGIKGVKYGRWLTAGNPQVFLLPMIYNSGTHFEHKIDHARNILRTACNLEIPNPGFGEREPYIWNAFLFGVVGWCFVSHAMSFLFTDVNVIMHSHEWIGCVAQVLYSRNGNCETGQRENHLHFLFTTHATTLGRHLSAGNICLMDCLQVLKEKSADQCASHWDMEASRRKIAVEHRIERAAAHTADVFTTVSEITGREAECFLGKTPDVITYNGMDVDSARSVGSDIGASHSYYHGKILDFCRGHFYGTTFNPEKTIIIFSAGRLEYKNKGYDMFLDALHSLNERFFRDPLLEDYKDITVVGIIIAPSQVSQYQVDTLKGISLMQEIKDCTRLLANKISTNLVDLLTNTALSQNLASLTLGDILSKNDIVLMKRCQQSYASRNNLPSIMTHTLRDPSLQDATEPILVRMRELGLVNQKESRVKVVWIPEFVSKTSPVGLDYNEFTLGGSLGVFCSLYEPWGYTSPECCCAGTPSIVSNLCGFGSFIESMVSRDTFKNRSKSVIEQSERLHHVASLTSISNLNSKRYPHSGSVSDYGASPRDSDTPSSPSGTTTPELRSKAVSNRILHQKSIEYIISEHDKNSWNMSKFGVQVVDRVYIDYHESVDRLANMLVDFVRLSPIERTNLRHKTERASVLCDWSAMISRYNEAHKLAITRRRKHFN
The following text describes a protein:
Function:
Lipid transfer protein required for autophagosome completion and peroxisome degradation. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region. The latter binding is assisted by an ATG18-PtdIns3P interaction. ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MNWIPNVQKRAFHYVLNRLALFSDLELDNMDISLGTAQKAALTNVKLDPDRVSLPAGMYMRSGKIDEVSVEMRLLGGAGIAVKIDGVHITASMKQMDVETATEHVEEFLERTTADLAASILSEDLSASLQIDPAEEPPLLGMGGSGISEALVKKVTQTVLSQLTVDVTNVHVTLFVAADDKMDLVVDEVRLRPQGGQEMALEVRGVKMKVMDKKARGTSAPVTAGSTAHATTGFTSESDSDSDTDPFSNAKKSLLQSTIFSHEEASSIYMSAIAESANLGFESDPLFGVFYVDTIDVLVFLGEEMRVSCEVGIVRASLDLLPTVILSLVKVGNGGSGGKKSRDSETKEGTAMDLNMSIKSISASICQLGDDWEFKNIDTNLLFSLSDISGSSGAFHKLQIGVCEVKRGSTRVFGFESDEKNTDDEEPTPRDSDILLKASSASFTLVLPKKAVGVFTIPDLIDVVSLITYLLSLIESKQQKAATMTERSERAGASKTTVQTNTFDFDVAGHKLYILPIRLSNGQMSLSRVSFGDVHVKGISFENSIVSVDKVDFDIGLPIVEELHQLLLPIIDAMNSAKNRPVPASVQTAPPKLLRIVEEPVNASSLVINVARVKGKVDLGGKVGVIEVVLGGISVTGPTDRIEISTVEIGRDLSDLGLSKKWLLHPLKRESNVVVELSSGQIQLITVKNCALEFYTELLELFGGKGDDTKAAELQESSSPDSSSRESSSGSESPPKRIPLQIHNCAVGLNPTNSSSSAQFIVKHVTCEIKPSPTFSMTSFIGSASLLLIDDASLVTPNPTDLMSSYLEQYTSVASLTATSISISTSPGNPTCININGDTVTLSTCADSTQTLIHLINSLKPAVELSGAKFQLETLDPFLNTFQDVDDCFFKAKNKDACESSCSSDNDDIDMVSDDVPNNMSFVESYYGGDKPSQSRKSGRQKMAESYTHADFLLDSDLDSLVKRERVRFEEICFEEDYFDKEEEDMPVMSRPRASSHDLASSNELLTPPTVVINIDLIHNIVCNFHDGYDWQYTRNEINGAVDGLKKRMKERPVVEEPPVMTTDLLFNSIYIQAKDEDDLDDVVGEQTEPAKPKEANKSRRGLLSRSSNPLVQVWLQGIACLLTVYAGLEDPDLPPGQVLNSLDVKIKDVEIIDHVPTSTWNKFLTYMRSRGEREAGAVMAHITMQNVKPVSTLSSQEVICHVTILPLRLHVDQDTLDFLTRFFNFKDVRTTAPPDETFIQKFDIRDVPVKLDYKPKKVDYSGLKSGKSTELMNFFILDESDMVLRRIKLRGITGFANLGQKLNDIWMPDVRRTQLPGVLAGVAPVRPLVNLGGGIRNLIVVPVREYKKDGRVVRSLNQGAYAFAKTTTNELVRFGAKLAVGTQNLLEGVVSTERAGESRDLDDSDLESTTKYYTYMGYSDSNNKLISLYANQPLGVYAGLQDAYSSFGKHMNVAKTAIHNLSEDISEADTAGAAAYAVVKAAPVALIRPIIGTTEAVSKTLFGVANEMDPSGRELARDKYKEAN
The following text describes a protein:
Function:
Binds the poly(A) tail of mRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MAFTGPNPSIWVGGLDPDLQEQKLYDYFVRIGPVTSVRVCVDSATQKSLGYGYVNFQDPADAEKALDQAGSKLGSRYLRIAKIQRDPSKRRSGVNNILVKKLPKSVDTYALKEMFSKFGRLTAIGLACDEKGESRGYARISFEREESAVDAVREMDGMEMDGQAIVVERYQAQHRDELLKQFTNLYVKNLDPAVTDEKLRAFFAKYGEVSSAKVRDLGAAQSEAGLGYVAFQKHENAARAVEELNGKECEIAKAGSPLDVSRFRSREERQRDRERQRRERAQQHSKYPNLYVKGFDDTVTSERLEELFQRYGETVSVTVMMDKETGVSRCFGFVSMKDQNAASQAIQELNGSTFLSPRPLFVTYALRKDARRQNLEERSKQFRVRQNPMGGPGMGAMPPIGFMGPQMFNNVNMPFMNPRVPIMPMNGMNGIGGMNGMGGMNGVGGVGGMGGMGGMGGMGGMGGMGGMGGMGSMGGMGGMARPMAPNAMSQMRSRPMPQKPPMQSLMPQQHQQAPPQGQNLAAVLANLNPEQQKNVLGERLYSYIVRSHPSVAAKITGMLLEMDNAEILNMLDSPTMLDSKIAEAQDVLNRHMSV
The following text describes a protein:
Function:
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by GAR1 to yield mature H/ACA snoRNPs complex. Acts as a competitive binder for CBF5 probably required to prevent non-cognate RNAs from being loaded during transport of the particle by inducing a non-productive conformation of CBF5.
Miscellaneous:
MISCELLANEOUS: Present with 1810 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Note=Mostly present in the nucleoplasm. Absent from the nucleolus.
Domain:
The central region (136-221) reveals a striking structural homology with the core domain of GAR1.
Sequence:
MSDDLFSKALENPDQDLNVELPKDDVDLGLLGDGGNERKTDEPVADAERSTGLGSGSSESESDSGSDSDSDSGSSGSEDDSADQDVEGEDEGGDAIENEDEDEDPSPSGPILSKNEILEETVPELPEDYEISEKTIITPIGVLKSAFENNIIIHATMSGEKRVLKEGSIFCLEDRTLIGMLTEVFGPLQNPFYRIKLPDSKKNLFDELKVRLGEKAFIVTPDAHWIDTFELKRNKGTDASNGYDEELPEEEQEFSDDEKEALFKKMKKQQRQRKKRDNRKLANDSDNVKVKRARQPKANSLPKLVPPLGMSSNAPMQHGYKSRNARENIKRESSATSNRNGSSPVPITQHHQQQFSANNYPFPQQPNGMPYPPYSPFPQPTNFQYPPPPFGQATPAQFSNTVPYGSLPPAYNNMSPPTQQSFMPMTQSQPPLPYGVPPMNQMQNPMYIQPPPQAPPQGNGNFQQVMELHQILLQQQQQQHQYQHQHQQDPRT
The following text describes a protein:
Function:
Has a role in sporulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MICKNTFVDYPTTQVRKERVHTYRTLTSATPSLEFFSNENTNRLSEVQCKLTHFLSSSENSSSVRNTRTHKFKQLLHYIFFSNRSSSVLGKQNVHNSQTLGSVSFCEKHAIDINYSENVNKQLNFESHLDDQTCSKRFYFNEQSGSDRYSLKCDSDTDSSTYFGDSASETCSSASNSLYKQTDLTSLCMFNQNKIQTDWSSIDPMDNDKIVCADFEKNFNILKELLNNTKDNGIDQQIVHKEHISHLEKIWKNINEESSEDPSLLLLRLEFLLTDLQTAIRKYSDTVSTNSVNEAFFDKIKIELQAFGVLV
The following text describes a protein:
Function:
FMRFamides and FMRFamide-like peptides are neuropeptides. SAEPFGTMRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system.
Subcellular Localization:
Secreted.
Sequence:
MISPNHLILLFCVNCAFLVASDATPKRSPLGTMRFGKRAIADEMTFEEDGYYPSNVMWKRSTVDSSEPVIRDQRTPLGTMRFGKRSAEPFGTMRFGKRNPENDTPFGTMRFGKRASEDALFGTMRFGKREDGNAPFGTMKFGKREAEEPLGTMRFGKRSADDSAPFGTMRFGKRNPLGTMRFGK
The following text describes a protein:
Function:
Plays a role in mitochondrial complex IV assembly.
Subcellular Localization:
Membrane; Single-pass membrane protein. Mitochondrion. Mitochondrion inner membrane.
Sequence:
MGVKLEVFRMTIYLTFPVAMFWIANQAEWFEDYVIQRKRELWPPEKEDQRRELEEFKERIRKQREEKLLRAAQQGP
The following text describes a protein:
Function:
Participates in various redox reactions through the reversible oxidation of the active center dithiol to a disulfide. The H form is known to activate a number of cytosolic enzymes.
Subcellular Localization:
Cytoplasm.
Sequence:
MAALASNPQMLTRQGHSNYKKEQFWRKESLNLEKKCGFCCVKVYNYEKLGRSQVEKEWRLKAFWSNVSQPETIEMVPINDVDELEAVLSDARNLSQPIIIEWMASWCRKCIYLKPKLEKLAAEYNNRTKFYYVDVNKVPQTLVKRGNISKMPTIQLWKEGEMQEEVIGGHKGWLVIEEVRELINKYV
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSTAARRSGGLFEGLYKVLMRRNSVYVTFVIAGAFLGERAVDYGVHKLWENNNIGKRYEDISVLGQRPTE
The following text describes a protein:
Function:
RAB2B effector protein required for the compacted Golgi morphology, probably through interaction with small GTPase RAB2B.
Subcellular Localization:
Golgi apparatus.
Sequence:
MNGDSLLPYYTAQSGSSMSMFNTTMGRLQRQLYKGEYDIFKYAPIFGSDFIQITKRGEVIDVHNRVRMVTMGIARTSPILPLPDVMLLARPATGCEEYAGHGQATKRKKRKAAKNLELTRLLPLKFVRISVHNHEKQQLRLKFATGRSCYLQLCPALNTRDDLFAYWEKLIYLLRPPMESNSSTCGIPAEDMMWMPVFQEDRRSLEAVDLQGKGDQDQVSIRSLHMVSEVCGATSAAYAGGEGLQHDFHKPTNVLNVSIPKTSTELAEEPATGVTKEAAAAGAAAGAATGTVAGALSVAAANSAPGQVSVAIAGVATIGAGGSKSNMAIAGTASMAPNSTKVAVAGAAGKSSEHVSSTSMSLSREGSMSLAIAGVELTSRTAAETDMDAAAGLPVSTRQSKSSLSGQHGRERTQASAEACKEGRERREKDKALGRSSRRRRTGESRHKTRGDKIARKSSSRSSFSHRASRDGKKEKGCSSPGSSRHGESHKGVSHTPISKESRTSHKSGRSSSTTSSGSSKRLGRISSFLRNVRANLTTKAVGTPHGRDVDIMAKTVERSTNVANAETAEGGQGLEMVGSMTPDIMETMTFETH
The following text describes a protein:
Function:
Catalyzes the oxidation of the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P)+. Has a preference for 1,2-dihydro-beta-NAD as substrate. May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers.
Sequence:
MTVPIAIIGTGIAGLSAAQALTSAGHQVHLFDKSRGSGGRMSSKRSDAGSLDMGAQYFTARDRRFATAVKQWQAQGHVSEWTPLLYNFHGGRLSPSPDEQVRWVGEPGMSAITRAMRGDLPVSFSCRITDVFRGEQHWNLLDAEGENHGPFSHVIIATPAPQATALLAAAPKLASVVAGVKMDPTWAVALAFETPLQTPMQGCFVQDSPLDWLARNRSKPGRDDTLDSWVLHATSQWSRQNLDASREQVIEHLHGAFAELIDCAMPAPVFSLAHRWLYARPAGSHEWGALSDADLGIYVCGDWCLSGRVEGAWLSGQEAARRLLEHLQ
The following text describes a protein:
Function:
Prenyltransferase; part of the gene cluster that mediates the biosynthesis of aspernidine A, a prenylated isoindolinone. The starting point of the biosynthesis of aspernidin A is the production of orsellinaldehyde by the non-reducing polyketide synthase pkfA. Hydroxylation, methylation of one of the phenol groups, and prenylation, presumably catalyzed by the prenyltransferase pkfE, would be needed to yield aspernidine D (Probable). Subsequently, the cytochrome P450 monooxygenase pkfB is responsible for hydroxylation of aspernidine D to yield aspernidine E. The dehydrogenase pkfF may be responsible for further oxidation of aspernidine E to form a dialdehyde intermediate which is further transformed in a series of steps, some of which are enzyme-mediated, to generate aspernidine A (Probable). The possibility that additional enzymes outside of the cluster are involved in aspernidine A biosynthesis cannot be excluded (Probable).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MYSKSWILNALPAPLVPYCELTRVGYLPIGVLVSYLPVLVAILHVAAVARLPYDNILDSCLQWLPLCYVYSAYGCVVDDIADQDLDRKVERCQHRPLVRGAVSTTSACLFAASLASLAVFLTKTFFPDQPAVHIPVALAGSIIYPFLKRFTNFALLYLAFLYVATGLNASRTIGYDILSAPDHLLTSNLLLAAAVFIANVSVETIYMHADLEDDIKSGIGSLAVKIQGYSKPVLFLAAVAYGSLVLASGLAAEFGKWYFTGAITSALTLFTLVARVDLKNGKMCEQFFFMGNAVLMSLLAAGLYGECIA
The following text describes a protein:
Function:
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Sequence:
MAAQTQRAVLAGGCFWGMEELIRRLPGVTATRVGYTGGDVPNATYRNHGTHAEAIEILFDPEATDYRALLEFFFQIHDPSTKNRQGNDIGLSYRSAIYYVDDEQKRIAEDTIADVDASGLWPGKVVTEVEPVGPFWEAEPEHQDYLQRYPDGYTCHFPRPGWRLPARSGSEG
The following text describes a protein:
Function:
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MKTYAAICLSLVSATAAFSPVPTKPVNTQISLTLDDIGGASAPLKNFDPLNLATLGSDETLLWFRAAELKNGRCAMVACVGYLTNVAGIHFPGQLSSDISFESLSTMNPFDAWGAVPVAGKTQILATIFIAEMITESKEVHYTKGGPLPGMVFPAIDFSGVSEETMKRKRTSELNNGRLAMIGMMSFIAAHNIPGSVPVLGSNF
The following text describes a protein:
Function:
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MFMHGYDSYMKYAWPADELMPLSCAGRVRGVTPSRGDVDDSLGNFSLTLIDTLDTLIVVGAYDQFEDAVKKVVDNVRFNTDLTVSVFETNIRVLGGLISGHLMAELLRGQQPQRLKWYTDRQLLKMAVDLGDRLLPAFNTSSGLPFSRINLRHGMMDHLKRQKDTCTACGGTMLLEMAALSRLTGNPVYEEKARKAMDFLWSQRHRSSDLMGTVLDVHNGAWVRRDSGIGAGIDSYYEYCLKAYILLGDNAYLERFNRHYDAVMRYVNKGPLFFDVQMHRPTIATRSFMDSLLAFWPGLQVLKGDISEAVQMHEMLFQVVQKHKFLPEAFTHDLQVHWAEHPLRPEFIESTYFLYRATRDPHYLEVAKTVMDSLNEHVRVKCGWAGVKDIRVMSHEDRMDSFVLSETFKYLFMIFAEPDDLIFDPDNYVLTTEAHFLPLNLGDSKENPLPRRLILDPDERLSDAAMRSVRTVLPLYGVPKSKERLGEEARAVRERTQSVLEELNALQRHADSHRNPQQVCAQNAERLRAIDFNPSNPAQLRQLEEMGITVTYGEDSRLLLTHQQTADGYPPLSCVLEAGSLQPVPGGAYHGPAPLSALWGAPWLGTSVVSQAALNQMTSLLLMVIVAWVLLMMAVGGVLLAMAAAARVGEKRELQQLQQEEEEERPQTSVGVAKSPELAQWGYMFMTEIQELAKAGAAESAPAPPAEPIYVQLLTTPHLALPVLTGSLALYGSKLRTQVSSRITIANPLRACSILTNPKEVKDAIVIVERSDCMFIEKTRAVQAAGGIGVIVIDHNPGTTWASSQSFSMSGDAKTDDDIVIPTLFLFRKEGEYLMKAVEAKQARKEDVRVGMGKVILDADHWFASWLAHLQRKGRKPLMEAPMCLHGDGLVARVVKEGNGPLYVQFAFRFGPVTMDSEPIEHQGIVERHVNHIGSIAEFESNEERHAFMNLLRAAGYHALGLSVKDEPLTPRLVNALRTAKIEESMPDSISGLTGSLVRVRCFATKGMIPRVLATDKTLVITPIRMADSEGSSSQQRQEEPAAAAAERAVRRRVRIQEEVEQEEILPTDQQHDRWANAGEAADDGDVSHRARRRKKRRELEQVHFKMVNDRVVDDITMDFFYKPHTIIILLAVCAFSLYKAVWDSNNASTDWNVYFGAKWTLGLFLVVSALAFPTGPFIRPHPVVWRISFGLSVAYALVLQFTVFQSFDDVKKVLSWLDPEGLSNDQLVEKEYAVNCFDLTLERMWSHMDIFAFAHFSGWVMKALLIRHGVLCWYISIIWELTEVVFTHLLPNFAECWWDSMILDVLLCNGLGIWVGLKICDYFQMRTFYWESIKDIETTRGKVKRAVLQFTPENFTRFDWFNESALRRTGALTVFCLIFLLVELNTFFVKHIFAVDTSHPVVFWRLIMIGAISAPSIRQFYVYATDPLCKRLGMQSWVFCAVTALESAVCIKFGRHMFPPMQLGIILGWMVIVVIGTFATIWVSIWWRVGVTSGTSQEKVGGQMRHLYVDSSYENLGLIHEDVRERRKQLRVASESEYTSDN
The following text describes a protein:
Function:
Common component of the spliceosome and rRNA processing machinery; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGSDSEVEKTAQKEKEIKKLLAIAPIAKPLAGKKLSKRTFKLVRRATEHKCLKRGVKEVVKSIRRGNKGSHCLVGNCRLCVIDGNISPVDVITHVLILCEESDIPYIYVPSKEDLANAGATKRPTCCVLVLTKLTKGELSQEDQEKLKEDYDRVVSEIRETTSSLF
The following text describes a protein:
Function:
Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney; [Isoform 6]: Non-functional protein.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Detected in the renal urinary tubules; [Isoform 6]: Apical cell membrane; Multi-pass membrane protein. Note=Localized at the brush border membranes of the proximal tubules.
Sequence:
MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWLKGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDWKLAAEEAKKHSGRQQQQRAESTATRPGPEKAVLSSVATGSSPGITLTTYSRSECHVDFFRTPEEAHALSAPTSRLSVKQLVIRRGAALGAASATLMVGLTVRILATRH
The following text describes a protein:
Function:
Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MVSSILKFVILIHSTFHSTFAQNLPDTTVAPKTKRTIKIGIAAAQRTQTSSIGWSVCGGAVPMAIERLREFGYVKDFDFEFIVDYTECDQGSVVRAGIEFIKTHKVDVIIGPPCAQALRVMSFLAENYKKPVLGWGFVSDTDLSDVIRFPYLTTVIPNSLMLGYAASKMLTVYNWGRVAMLYYYSDIKYCSGVMNDVEATFNNPSTPNVNIVIKAEIYLNDNETTDIVFQSVKSRARIIFWCTQTAIEKRDYLIKIATHDMIGDEYVHIMLSMRNIAFGAQTSLGKPTFSQSGLTPIWESFTEGTDDFEKMVKQAATRMFVLDVNSEVADKKYLDYLQKNIMKAVQSPPMNCSTVECMTANTTIMGGYARQLFDVVYLYGVALTNTNSTDPAVYDDVDVIVPQFVTSFQGMTGKVVISPNLTRMPIFQLYGLNSDYEQVALAEFTYIDPIMNVTLSYKEEGGAVWYFYGNSRPLDIPICGFLGKFCPISFWEQYMILAIVSISVIVLMVIIMIIGCLCVISAKHAEQARTNAEWQVPFVNLMESEKQIRSNATSRRSLQSAPSISTGHSGVTTVSDFCENYTMMMYEKEMVLTAKYQYTHLTKADKERFVKMRKLDHENINRFIGLSIDSAHFIAVTKLCSRGSLQDILSRGNFSMDYFFMFCIIRDVAKGLEYLHKTFLRLHGNLRSATCLVNDSWQVKLAEYGMDNLVEEQTPPKKRLLWVAPEVLRGSLSVSQMEPSADIYSFAIIASEILTKKEAWDILDRKEDCEALIALVKDCWAEVPEDRPTAENICSQMKGLVSKQKTNLMDHVFNMLEEYTSTLEEEIEERTKELTLEKKKADILLSRMLPKQVAERLKAGQTVEPEGFDSVTVFFSDVVKFTILASKCSPFQTVNLLNDLYSNFDTIIEQHGVYKVESIGDGYLCVSGLPTRNGYAHIKQIVDMSLKFMEYCRSFKIPHLPRENVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLTSDAHLLLLTHYPNHYDTSSRGEVIIKGKGVMETFWVHGRIDDIAEPTELRSICKPSTVANERWITPPAPKPEIRSVSSHGSRPPSVYDPLQDHRKFKMDTLKVAN
The following text describes a protein:
Function:
Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.
Sequence:
MDGYHFLGLDLSTQQLKAIIIDQDGKPVHTEFIPFNNYSEKYGTKDGVLKNGQVITSPVKMWLEAIDDLFEELRKNGWLKQLKGISGCAQQHGTVYWKKEAELILNNLESEKSLREQLENCFSVENSPVWMDSSTEKQCQEMENFVGGDMKMSEITGSRAHHRFSGAQIKKIVEDGKGTWKITERVFLISSFMTSLLLGKYAPIDKTDSSGMNLMDVQNEQWHQPLLNFIASDLGEKLGDPVDSMCVLGSVNSYWTNKYGIPSSCLILPFLGDNPSSLAGLALLPIDIGISMGTSDTVFCFSPEFKPNPEAHVFCHFAPNSGYMAMVCFKNGSHTRERARKLNGCPWEDWEKVMKKTPIGNDGYIGFFFDDDEIVPRKPKGDYTFEIESEELNRNPEKFARAVFESQCFFKLFYTQKMGFQKSTSSRIVVTGGGSRNTSLLQMLSDVFEMPVYSIEVDGSAALGGAMRARYLLSKTSMSYSEYYPCDNVELQCKPIPGNSEIYRVQFEAFKNRLDAFIKEN
The following text describes a protein:
Function:
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells (By similarity). Component of the BTR double Holliday Junction dissolution complex, which is involved in homologous recombination during meiotic double strand break repair in the germline (Probable). Promotes top-3 binding to double Holliday junctions (DHJ) and hence stimulates top-3-mediated dissolution (By similarity). Stabilizes and positively regulates the localization of the BTR double Holliday Junction dissolution complex components rmif-2 and him-6 at nuclear foci during meiotic recombination. Plays a role in double strand break repair by regulating the accumulation of rad-51 at double strand breaks during meiosis. Positively regulates chiasma formation and DNA crossover designation, formation and positioning on chromosome arms (away from the chromosome center) during meiotic homologous recombination. Specifically localizes him-6 to DNA crossover sites along chromosome arms. Also plays a role in the repair of non-crossover homologous recombination intermediates during meiosis. Not required for chromosome pairing and synapsis. Together with rmh-2, positively regulates larval development.
Subcellular Localization:
Nucleus. Chromosome. Nucleus, nucleoplasm. Note=In early development, first localizes to the nucleoplasm then as development proceeds progressively accumulates on foci on chromosomes. Co-localizes with rmif-2 in nuclei foci during pachytene in meiotic prophase I. Localization at nuclear foci is dependent on rmif-2 during meiotic recombination. Accumulates at nuclei foci as pachytene progresses, peaking at mid-pachytene. Co-localizes with him-6 at mid-pachytene and late-pachytene in meiotic prophase I. Does not localize to nuclei foci during diplotene. Localizes to nuclei foci at crossover sites and non-crossover sites on DNA homologous recombination intermediates. Co-localizes with cosa-1 and msh-5 at DNA crossover sites during meiotic homologous recombination.
Sequence:
MKETELDRLFSWLARKHYPFKREWLRICVQYIEGSLGQRIKTVDVKQIGELVIQQFLNSKISEALDPTMKIPTSAVKVVIVKRMIFQVISSTNISTSLYEQLSECTRHNEDLAWFHGGSKADHEEENRDKEKDVASDRMNHTQTKNAIKKRGMLKIELTDGVNTLKAIELDEVFDEKIMLPGAKIILTGKVKCRRGNLLLDKSNCAFLGGRVESLSFDKVAQLSNALKVDLDAEKKRRKASLENAAASVSRNNKKQIDKKNLSLNQSSLSPFLVKTSRITGEVTVPVKQSLVPTASRILPSSVAVIPSIQIEKPTDPIENWDFSIEEVPQEPTPEPPSHHVRGLVEHYPLRSKPQDPLPPPPTKRLSSLIIDKNSISKVSQNISNQVEKGLLQNKTIEDWTFNSTNSFDKSKKVMSIDNSKDQKMKIKELPGQLIRPTPIEKPIIGDPRMNSEKRKDVSVWVWEDRKGSEEEDIAAKRIKKIDSVMEIPLCFVKETTRQANRSNEESRHKLNTFAQTIHGPRSKIDDFRVKSNNVPVFKQITDHFITVKSNPNSFTSSTRHTPPQMPKVVDFGNFEDYDEDYEDEVLPTSSFRDQLKQRKSLDNHGEDVVLEEEMDHVDHDESIIECTMDHEGRLECERWGLRGRESNIIEDDKRNVYNGYNMNNNIERDNKYDSSMNGMPQPNLQHPLSILPPPPVIPPSQNWNYTGYYQAPPLRNVIKSETVDSVVPEDQKMVGAQGKKRPNVRQENDNMKNKQSANVQVYRTPFAERLNSGDSSSKLSPQLFQRMADLQIVPFGDALFNRKFWMMSKIVVIMPSICSQIHELQSDGIDWLLQIRVTDTSVKNVICRVSTSLLNRIFGFDVQQCKNLFNKNQVEELRAKKCEAERKLLGFKRLDLLLWVEVSPERNQIPLILDVKTISDALNIL
The following text describes a protein:
Function:
Required for the cytoplasmic assembly and the nuclear import of RNA polymerase II. May facilitate the starting interaction between RNA polymerase II subunits RPB2 and RPB3 and the subsequent interaction of the resulting complex with subunit RPB1. May also participate in the transport of RNA polymerase II through the nuclear pore complex.
Subcellular Localization:
Cytoplasm.
Sequence:
MNEDKEQKINIHDILNTRPKLTKKTALDVFFEDLDDNVITPINEYVLDSGSSSSSSIYQALKCSNNNEFVAVLLQKFQNLHIHVLEQQRRLIESKSDLLPISLHDMKYVDELINLLIIHGIDANLSPTMKIPFDSKRINTFKKGQKSAEYETPRWHTINNDTLSQVITVFYNVLTSERSSDYLREIISKGSAYANILLGLIVLHLQLPNRYSSQMITNLEDTQETYTLFGVYTLLVETIQDEKVREPILSKLTTLTLRRPENGLISLIDFVLGVRDAEDIDIEKFNRIYQILMSKPKTMTNLQYLTELFKQIYDGLTFVNRPILVTCLNGLILKFYLRNKRIVNDFLFKKVRSIIFNSPLTDHTAKELNDVINVLISLSKNSSSDLLNDLVTSCPDEDGTTPGQFFLYVWIYALFLKKNQKLDPLEINKLSISDNKSTDSIHFPEQSSSKYYEVVLSLLKSLIVITENFQYLNVLSLNLLNFEHEKWKYLIDLDTQLPYISVKNTDMAELFFEKGSKNSQISEFLQDMDLSIELFMEFLVLLNDEEQSKTLFLDILKRWVHHTKKSEKRSSDNHSGMPSVTDNALILMDLKLLECMNNRFKTKIVNKPKDVLIVIDQLIDVVQEKDETIQEVEADSDDEVEEGEETEELDPNENSSYKIILQLLSTVLSESSSSILLQNSYILKSISRKLQSFNTNASEIDALLASIDNILINGHTTERNDNIEIEMDEERLDKAITSLHDPLVPIKSYGLTELRHLAEKKSPVISLEKVLQIHLDYLKNMDPFIYLNVIKGLTTLCELEPETILPLLAEFYANKKKKNRLDDVLKVGEVFINYIQRQNELFQGKLAYLIIDTCLSIVRPNDSKPLDNRWRMSSMSILGMCLQINARGVSDRIRDMLDCVFGILQLEQPQNHLKDKDDSFLMRRSAVHLIHDLLYSTGFDLLPFEYNYDKLKTLLSYVRDQDEDYMVCEQIDKLLTVLDSL
The following text describes a protein:
Function:
Histone methyltransferase family member that plays a role in gene silencing. Together with MORC6 and SUVH2, regulates the silencing of some transposable elements (TEs). According to PubMed:19043555, the protein does not bind S-adenosyl-L-methionine and lacks methyltransferase activity. Instead, it may function downstream of DRM2 in RNA-directed DNA methylation, binding to methylated DNA and recruiting DNA-directed RNA polymerase V to chromatin.
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Domain:
Although both SET and pre-SET domains are present, the absence of the post-SET domain may explain the lack of methyltransferase activity. Besides, the Cys residues in the SET domain that normally bind a zinc ion are not conserved; In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Sequence:
MGSSHIPLDPSLNPSPSLIPKLEPVTESTQNLAFQLPNTNPQALISSAVSDFNEATDFSSDYNTVAESARSAFAQRLQRHDDVAVLDSLTGAIVPVEENPEPEPNPYSTSDSSPSVATQRPRPQPRSSELVRITDVGPESERQFREHVRKTRMIYDSLRMFLMMEEAKRNGVGGRRARADGKAGKAGSMMRDCMLWMNRDKRIVGSIPGVQVGDIFFFRFELCVMGLHGHPQSGIDFLTGSLSSNGEPIATSVIVSGGYEDDDDQGDVIMYTGQGGQDRLGRQAEHQRLEGGNLAMERSMYYGIEVRVIRGLKYENEVSSRVYVYDGLFRIVDSWFDVGKSGFGVFKYRLERIEGQAEMGSSVLKFARTLKTNPLSVRPRGYINFDISNGKENVPVYLFNDIDSDQEPLYYEYLAQTSFPPGLFVQQSGNASGCDCVNGCGSGCLCEAKNSGEIAYDYNGTLIRQKPLIHECGSACQCPPSCRNRVTQKGLRNRLEVFRSLETGWGVRSLDVLHAGAFICEYAGVALTREQANILTMNGDTLVYPARFSSARWEDWGDLSQVLADFERPSYPDIPPVDFAMDVSKMRNVACYISHSTDPNVIVQFVLHDHNSLMFPRVMLFAAENIPPMTELSLDYGVVDDWNAKLAICN