lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MAGGAAKYRHLSRKSSHRQALLRNLVTSLFKHESITTTWAKAKEAQRLAEKLITLGKKNTETSRRTALSTFYTPHEILPKLFGPLRERYADRPGGYTRVLRVEPKKDDQAPSAILELVDGPKDMRFALTAKAVARRRSQGLQTLNELTLLNVRKVTQFRKNGVEELEKAISKIKLDEVNSPVKSKATMKNEKTAEHARVVKEAERQSEESL
The following text describes a protein:
Function:
Associates with the SIT4 phosphatase in a cell cycle dependent manner. May be directly or indirectly involved in SIT4-dependent functions in budding and in normal G1 cyclin expression (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 279 molecules/cell in log phase SD medium.
Sequence:
MSLWPFGETLSHSGIDSILEEYYLIFRSLEGNETSSTDDKKNEPSMESESEFGTESRDRSDLNQSFIDRILLETALLDELNGAANDRLVDFICLGYFYDDRSQQVRHMDYLVDMLMAYLKDIDRTGYRTPFLLENSFHQTGEYEDQDDEDPMLYVNIISSIFCSKSAPIVEALVQNTPFLSSLFEVFQFENIEAENCPILAVFLKINETLLFEQTSSYLEFFKSQPNIVDKFLYHIEVSPLVEFLIKIMLTDQVESPTNIIDFLYHQDLIPKCLNLLENSKYSPGIQNSSGELLKALISISTNFKLDTLWIGPNRLTRQLASPQYVDQLINIILFQRGHAMGVAVSIIIELIRKNNSDYDEVDLLSTTIVDNPPSQRDPVYLGHLLYELTMHMEDFYALLIKLENDDDDDHDTASKALPSVKHHLLENQLHESFRPLGFERVKITELISEMLHCSNMGLMNSKRGEKIARTRDKCRDTLDQNSLEKAMKNLNINDNTITSNTLEDKCNNNDSNDSNDNQKQKKNIKKKFHDNELYSTFDTSDDNIDDDDDMSFEIPYVSETQNLKIRKNPTIGDLFKIKLHDLGFFPKFLQLFLRYPWNNFWHNIVFDIIQQIFNGRMDFSYNSFLVYSLFDFKKSTRFIPKPLYGSNQKLPVKDFHIISDFILQGHKDSFEFYEKEKTNLGYMGQLVLIAEEIAKYSKIYKTDLIAPDIYAFLQDEVWMSYSSDILNETRTMCSIILGGGQFCAESDENTNQDFLEKADMSKPAHPSTMDENEIVHEEDVKLHDKVAELIDELGQLTELDIHDKIKDVIVDHHSDLN
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MTSPPPSLLPSCPLSERASNESSSMLRPRPLQPSSTENPRNTTSRLKPTAYDSIPIDGSSEDELLRYSEALTREEVLRRRSRRLKQLSRISRNQYWALMEEVKLLHRKYYWKFGRSPMVKSSPDARKDGSEEMEITDKFPVCVFSGCKTKPMALTTYCFQHILSDQRQTLYRPCTYVIKSSAQSKPIACGKPYMRSTVPTYCSFHFDMAKNYLSQALKKSISNQTSSGRIAPKAHEVVYKLIQCAQHNRIILRSIENSGVE
The following text describes a protein:
Function:
Confers resistance to heavy metal ions (e.g. cadmium (CdCl(2)) and copper (CuCl(2))) by chelating them at the plasma membrane of root cells, thus stopping their entry and reducing their accumulation. Binds to aluminium (Al).
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Secreted, cell wall.
Sequence:
MYNAPMAQDMSYYEHVQRRHEEKGCLYACIFTALCCFCCYETCECCLDCLCCCCN
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Sequence:
MTPVLYYLPPSPPCRSVLLLAKMIGVELELKALNVMEGEQLKPDFVELNPQHCIPTLDDHGLVLWESRVILAYLVSAYGKDENLYPKDFRSRAIVDQRLHFDLGTLYQRVVDYYFPTIQLGAHLDQTKKAKLAEALGWFEAMLKQYQWSAANHFTIADIALCVTVSQIEAFQFDLHPYPRVRAWLQKCKDELQGHGYKEINETGAETLAGLFRSKLKQ
The following text describes a protein:
Function:
Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells. Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Located at tricellular contacts.
Sequence:
MAPAAGACAGAPDSHPATVVFVCLFLIIFCPDPASAIQVTVSDPYHVVILFQPVTLPCTYQMSNTLTVPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFEQTAWGDSGVYYCSVVSAQDLDGNNEAYAELIVLGRTSEAPELLPGFRAGPLEDWLFVVVVCLASLLLFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSIYTHLSPAKTPPPPPAMIPMGPPYGYPGDFDRHSSVGGHSSQVPLLRDVDGSVSSEVRSGYRIQANQQDDSMRVLYYMEKELANFDPSRPGPPNGRVERAMSEVTSLHEDDWRSRPSRAPALTPIRDEEWNRHSPQSPRTWEQEPLQEQPRGGWGSGRPRARSVDALDDINRPGSTESGRSSPPSSGRRGRAYAPPRSRSRDDLYDPDDPRDLPHSRDPHYYDDIRSRDPRADPRSRQRSRDPRDAGFRSRDPQYDGRLLEEALKKKGSGERRRVYREEEEEEEGQYPPAPPPYSETDSQASRERRLKKNLALSRESLVV
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MAGGVSEARFAGLSLVQLNELLEDEGQLTEMVQKMEETQNVQLNKEMTLASNRSLAEGNLLYQPQLDSRKARLTQKYQELQVLFEAYQIKKTKLDKQSSSASLETLLALLQAEGAKIEEDTENMAEKFLNGELPLDSFIDVYQSKRKLAHMRRVKIEKLQEMVLKGQRLPQVPAPAPLPPRVPEPAPAAPLPYPAPEASGPPSVVPRRMPPLPPPVPAGRLATPFTAAMGSGQALPYPVAQCPPLPPRGGLPAQQGFSTQQFVSPPYPPALPQRPPPRLPPHQPGFILQ
The following text describes a protein:
Function:
Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. Binds GPI-anchor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGVLMNTSQNSKLILFVQKQCNRICFLSYVAGVVCFALLAWDGCNNKTYFSENALLPGLVQRRFRLSEAARDILESLKEEAQNHASLPLPWLLGQFRQLGLDVHRHNFSLHYPLGSKPTHTGENVYAILRAPRAASTEAVVLSSPYRTEDNLHGSSLPGIALMIAMAKYFRMQGFWAKDIIFLVTEHELVGFQAWLDAYHDMHTSPGGWLIDPGVLNGRSGPIHAAINLELHTDRIRRLDLKLVGLNGQLPNLDLFNLVVELCLRESVHTTFHDQVSPYETESFEGWKQSFKTMAAMMAAQASGLPNGGHGLFHRYAIQALTLEGHGDGEAAVRVGFYEIGRVLEGVFCSLNNLLERFHQSFFFYLLPSTRRYISIGLYSPALALIALPTLVKVRHLLSECLCGTHSLTSLWSALPYTAVSLGVGLLLMVAPPYLDQLGHRFQLSSQDSLYYGYVIMLGLSLLMPLFSGCFYVSTRGDKKHARKCSLLLIFAAVVHPLALVNISMATVVSLLAVPVLVTAGGTGNRFLLVFHRLLQLLIHPFVLSFVLIFVQAMSLDSWQPHSIRNNLGHAFQGHKKLVMFSVEDWLLYGNWTFVISALGLIPVWLQMWML
The following text describes a protein:
Function:
Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable).
Subcellular Localization:
Nucleus.
Sequence:
MFGLDQFEPQVNSRNAGQGERNFNETGLSMNTHFKAPAFHTGGPPGPVDPAMSALGEPPILGMNMEPYGFHARGHSELHAGGLQAQPVHGFFGGQQPHHGHPGSHHPHQHHPHFGGNFGGPDPGASCLHGGRLLGYGGAAGGLGSQPPFAEGYEHMAESQGPESFGPQRPGNLPDFHSSGASSHAVPAPCLPLDQSPNRAASFHGLPSSSGSDSHSLEPRRVTNQGAVDSLEYNYPGEAPSGHFDMFSPSDSEGQLPHYAAGRQVPGGAFPGASAMPRAAGMVGLSKMHAQPPQQQPQQQQQPQQQQQQHGVFFERFSGARKMPVGLEPSVGSRHPLMQPPQQAPPPPQQQPPQQPPQQQPPPPPGLLVRQNSCPPALPRPQQGEAGTPSGGLQDGGPMLPSQHAQFEYPIHRLENRSMHPYSEPVFSMQHPPPQQAPNQRLQHFDAPPYMNVAKRPRFDFPGSAGVDRCASWNGSMHNGALDNHLSPSAYPGLPGEFTPPVPDSFPSGPPLQHPAPDHQSLQQQQQQQQQQQQQQQQQQQQQQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQLGHPGDVGQGGLVHGGPVGGLAQPNFEREGGSTGAGRLGTFEQQAPHLAQESAWFSGPHPPPGDLLPRRMGGSGLPADCGPHDPSLAPPPPPGGSGVLFRGPLQEPMRMPGEGHVPALPSPGLQFGGSLGGLGQLQSPGAGVGLPSAASERRPPPPDFATSALGGQPGFPFGAAGRQSTPHSGPGVNSPPSAGGGGGSSGGGGGGGAYPPQPDFQPSQRTSASKLGALSLGSFNKPSSKDNLFGQSCLAALSTACQNMIASLGAPNLNVTFNKKNPPEGKRKLSQNETDGAAVAGNPGSDYFPGGTAPGAPGPGGPSGTSSSGSKASGPPNPPAQGDGTSLSPNYTLESTSGNDGKPVSGGGGRGRGRRKRDSGHVSPGTFFDKYSAAPDSGGAPGVSPGQQQASGAAVGGSSAGETRGAPTPHEKALTSPSWGKGAELLLGDQPDLIGSLDGGAKSDSSSPNVGEFASDEVSTSYANEDEVSSSSDNPQALVKASRSPLVTGSPKLPPRGVGAGEHGPKAPPPALGLGIMSNSTSTPDSYGGGGGPGHPGTPGLEQVRTPTSSSGAPPPDEIHPLEILQAQIQLQRQQFSISEDQPLGLKGGKKGECAVGASGAQNGDSELGSCCSEAVKSAMSTIDLDSLMAEHSAAWYMPADKALVDSADDDKTLAPWEKAKPQNPNSKEAHDLPANKASASQPGSHLQCLSVHCTDDVGDAKARASVPTWRSLHSDISNRFGTFVAALT
The following text describes a protein:
Function:
Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Binds cardiolipin. May form molecular condensates (non-membrane-bounded organelles) within mitochondria that compartmentalize and promote cardiolipin metabolism.
Subcellular Localization:
Cytoplasm, cytosol. Mitochondrion outer membrane. Mitochondrion matrix. Note=Localizes to the cytosol under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress. May form molecular condensates in the mitochondrial matrix. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane.
Sequence:
MAENLKRLVSNEALRTLQEKLDSWLKEYNTNTCDQNLNHCLELIEQVAKVQGQLFGILTTAAQEGGHNDGVETIKSRLLPWLEASFTAASMGKPVDSKVPSLQNTFDRERRKDPSPRDRDMQQLDSNLNSTRSQLNQVQDDLAETEKNLEETKNRSAISLLAAEEEINQLKKQLKTLQAQEDARHRHTDQRSSENRRSEPRSSEERRCEQWSSLKRNADQRDTEVTSDYKKQLRNLKEEIAVLSAEKSALQGRSSRSRSPSPAPRSRSCSRSRSASPSTAVKVRSPSPNRSKLSNVARKAALLSRFSDSYSQARLDAQCLLRRCIDKAETVQRIIYIATVEAFHVAKMAFRHFKIRVRKSLTPSYVGSNDFENAVSDYVICHLDLYDSQSSVNDVIRAMNVNPKISFPPVVDFCLLSDFIQEICCIAFAMQALEPPLDIAYGADGEVFNDCKYRRSYDSDFTAPLVLYHVWPALMENDCVIMKGEAVTRRGAFWNSVRSLSRCRSRSLSPICPRSQIGLSTMSRSRSPSPIRCGLPRF
The following text describes a protein:
Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAALWRLSVLCGAREGRALFLRTPVVRPALVSAFLQDRPAQGWCGTQHIHLSPSHHWALDKLLLTMFMEMQCRKLPRQAFWCSRLSPLLGSVTSTIMTWASAKLWLCCGSSDLLDLIP
The following text describes a protein:
Function:
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MESTLGAGIVIAEALQNQLAWLENVWLWVTFLGDPKILFLFYFPAAYYASRRVGIAVLWISLITEWLNLIFKWFLFGDRPFWWVHESGYYSQAPAQVHQFPSSCETGPGSPSGHCMITGAALWPIMTALSSQVATRARSRWVRVMPSLAYCTFLLAVGLSRIFILAHFPHQVLAGLITGAVLGWLMTPRVPVERELSFYGLTALALMLGTSLIYWTLFTLGLDLSWSISLAFKWCERPEWIHMDSRPFASLSRDSGAALGLGIALHSPCYAQVRRAQLGNGQKIACLVLAMGLLGPLDWLGHPPQISLFYIFNFLKYTLWPCLVLALVPWAVHMFSAQEAPPIHSS
The following text describes a protein:
Function:
Required for vacuole biogenesis and vacuole enlargment in dividing and expanding cells. Involved in the docking or fusion of prevacuolar vesicles.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein.
Sequence:
MSSSVSVAAEWDLLSDRFYRRLTLYSPLPWSAPAPTSTSSSSGVGGPVIGRLDLSTHIVAAAPFGGPIAAVRDDSKIVQLHSEPSRRRLLLFSSSGHPIASAPWPPMLPRLHSLAFSSSLSLLGLISDGSLLRFRLPDLQPSPSSSPMPLLPPASGGVADAVFWGGGVAILTEDNRVVVATDIEADDPHPRDLADPGVGDEEHVLCMAVVEPQFVMSGSPEVLLAVGDRVVAVDEDGVQVLGEELEIGPVQKMAVSPNGKLLAAFAHDGRLLVIPTDFSRIIFEYECDSALPPEQIAWCGLDSVLLYWPEVLLMVGPNGDPVQYNYDEPIKLIPECDGVRILSNSSMEFLHRVPDSTTLIFGIGSMSPAALLYDARDHYDRQSAKAYDNYQLISSSLPEAIEACIDAAGHEFDVSRQRTLLRAATYGLAFCSRFPHERFQEMCKMLRVLNAVRDPEIGMPLTIQQYKLLTAPVLIGRLINANQHLLALRISEYLNLNPEVVIMHWACEKITASASLPDTVLLEGLLDKLRLCKGISYAAVAAHADNCARRRLAAMLVDHESQSSKQIPLLLSIDEQDKALSKAIESGDTDLVYLVLFHIWQKVAIEKKAHLDFFGVINARPVARDLFIAYARHSKHEDLKDFFLSTGRLQDAAFLMLKESSELEKNPMASKGSHLQQVRPIEQAHRLFAETKEHVFESKASEEHAKLLRSQHELEVSTKQAIFMGSSVSDTIKTCIAMGNERAALKVKSEFKVPDKRWYWLKTCALATVGNWDALEKFSRERRPPGGYKPFVEACIDAGQKTEALKYIPKLTDPRERSEAYARMGMAKEAADAASQAKDSDELFGRLKITLAQNSAAASIFDTLRDRLSFQGAY
The following text describes a protein:
Function:
GTPase-activating protein for Rho1. Has a role in the negative regulation of (1-3)beta-D-glucan synthase activity and cell integrity.
Subcellular Localization:
Membrane. Note=Membrane-associated. Localizes to the cell poles and septum.
Sequence:
MTVVVGVLQIDDMGKKSSFASWWKQLRVKKSDDNKLFGLSLTRALEVSKVAIFLTRRDGEKVFYGYIPAVVAKCGFFLKQNATQVKGIFRVNGSSKRIQILQKAFSTGPDYGRSFDWEGYTVHDAANVFRRFINLMPEHVIPLEYYERFREPMTIPNLTDNERVEMYRRRIDELPIPNRQLLLYLLDLLSVFAMNSSKNLMTADNLAAIFQPGILSHPDHEVYSKDYQISQTALLFLINHQGSFIKTIPLSSLPPLVAAPTSPNTSSTLITQSAAPTPIASTSIRINSFNPRNGSIKRWRSFSRHSSATYSNSPSSNFSNMKSSEVDPGSPPRIKSRSYSLSRSSSMKLFHTLDRRRENRM
The following text describes a protein:
Function:
Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps, which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing. Significantly decreases macrophage phagocytosis possibly thanks to the clumps, clumped bacteria being too large to be phagocytosed. Dominant factor responsible for human platelet aggregation, which may be an important mechanism for initiating infective endocarditis. Enhances spleen cell proliferative response in vitro, contributing significantly to the immunostimulatory activity of S.aureus.
Subcellular Localization:
Secreted, cell wall; Peptidoglycan-anchor. Note=Found in a ring-like distribution on the cell surface. Does not localize with SasF. Exchanging the ClfA and SasF signal peptides retargets the mature protein on the cell surface. Anchored to the cell wall by sortase A (Probable).
Sequence:
MNMKKKEKHAIRKKSIGVASVLVGTLIGFGLLSSKEADASENSVTQSDSASNESKSNDSSSVSAAPKTDDTNVSDTKTSSNTNNGETSVAQNPAQQETTQSSSTNATTEETPVTGEATTTTTNQANTPATTQSSNTNAEELVNQTSNETTSNDTNTVSSVNSPQNSTNAENVSTTQDTSTEATPSNNESAPQSTDASNKDVVNQAVNTSAPRMRAFSLAAVAADAPVAGTDITNQLTNVTVGIDSGTTVYPHQAGYVKLNYGFSVPNSAVKGDTFKITVPKELNLNGVTSTAKVPPIMAGDQVLANGVIDSDGNVIYTFTDYVNTKDDVKATLTMPAYIDPENVKKTGNVTLATGIGSTTANKTVLVDYEKYGKFYNLSIKGTIDQIDKTNNTYRQTIYVNPSGDNVIAPVLTGNLKPNTDSNALIDQQNTSIKVYKVDNAADLSESYFVNPENFEDVTNSVNITFPNPNQYKVEFNTPDDQITTPYIVVVNGHIDPNSKGDLALRSTLYGYNSNIIWRSMSWDNEVAFNNGSGSGDGIDKPVVPEQPDEPGEIEPIPEDSDSDPGSDSGSDSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSDNDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSDSDSDSDSDSDSDSDSDSDSASDSDSGSDSDSSSDSDSESDSNSDSESVSNNNVVPPNSPKNGTNASNKNEAKDSKEPLPDTGSEDEANTSLIWGLLASIGSLLLFRRKKENKDKK
The following text describes a protein:
Function:
Component of the DNA topoisomerase VI complex. Binds to DNA. Required for chromatin organization and progression of endoreduplication cycles. The loss of BIN4 activates the ATM- and ATR-dependent DNA damage responses in postmitotic cells and induces the ectopic expression of the mitotic G2/M-specific cyclin B1;1 gene in non-dividing cells.
Subcellular Localization:
Nucleus.
Sequence:
MSSSSREGSPDWLRSYEAPMTTSLLSLSSSDDDSPYRESEVISSLPLPDDDGDDIVVLETESVELLTRKNSETKVVTKQVSIEQVFSRKKKADASLNLEDSCAGKENGNNVDCEKLSSKHKDAQGGADSVWLVSSDSEPSSPIKQEVTVSTEKDADFVLEATEEEPAVKTVRKEKSPKTKSKSSRKTPKEGNSAQEILKTEDKDTDTTIAEQVTPEKSPKTKSKSSRKTPKEENCAQEILKTEDKDKDTDTDTIIAEEVTTDQKIKPSSGSSSRLPLVLSEKVNRTKVLVECEGDSIDLSGDMGAVGRVVVSDTTGDMYLDLKGTIYKSTIIPSRTFCVVNVGQTEAKIEAIMNDFIQLIPQSNVYEAETMVEGTLEGFTFESDDESNKNAKTAVKPADQSVGTEEETNTKAKPKAKAKGETVIGKKRGRPSKEKQPPAKKARNSAPKKPKAKK
The following text describes a protein:
Function:
May act as a scaffold to regulate the recruitment and assembly of spindle midzone components.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Midbody. Note=During early anaphase, localizes along overlapping interpolar microtubules between the separating chromosomes. During late anaphase, localizes to the center of spindle midzone. Concentrated at the midbody during telophase.
Sequence:
MGCKTSKMCCPQLRKKKRQKAHQGGLTSQELNDLNAKTQGPNEVLQKIKEYEQEIRDLLQKHQEEKTALADAHKADVEARTLELQAQAQKDRDAETAKLLSEQAATMKAEMEEKFAELQKSFEQEKVSLTQTHQQFTDALQETVDELNSQLASFREKMKRVEESVLRQDYRRHIQDHGSPGQFWEQELQSLHFVIEMKSELIREQDKRLRNHESTMERNLVLEERSRTLQQENEALKVQTQKQGAVTVRLSEELLSTQVSLEKQIHRCEQLQREKEQNLYRAVNGDAPQQFSLQSNAQELPVMVL
The following text describes a protein:
Function:
Golgi membrane protein involved in vesicular trafficking and spindle migration.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MPQLPTSSDREYRYNYNQDSSFSTLRNVLTTKLAAVSDIIQQARTWYLEQSTIKQILLGGALVVIGVISVLMVIFHIHIIRFLIYLSDEWHNLKYGSLIIFALVFMVGFPPLIGFSALSFLTGMIYGCPQGWPLIASASVLGSTCSFIVYRYVLHNQAVKLMNHNDTFRAFAEILGEGNSLFLLILIRLCPLPYSLSNGALAAIPELPLLTYFLATLITSPKILIHLFVGSKLKQIGDDKSSGGTKIVDIISIVITGTAATLAAYLIYAKMQQKLASYHSRGIAADDVMVFGNFEDDLELGSNEIELNSADFDADNFIIEDDDNEDDPRQQGNTNNAKKDNGVQTSEEIL
The following text describes a protein:
Function:
Positive activator of the proline utilization pathway. Binds to the promoters of PUT1 and PUT2 genes. Recognizes and binds to the DNA sequence 5'-CGG-N(10)-CCG-3'.
Miscellaneous:
MISCELLANEOUS: Present with 736 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MVTDQGSRHSIQSKQPAYVNKQPQKRQQRSSVACLSCRKRHIKCPGGNPCQKCVTSNAICEYLEPSKKIVVSTKYLQQLQKDLNDKTEENNRLKALLLERPVSVRGKDNSDDDERHINNAPSSDTLEVSSAPAAPIFDLMSNSNTASDNDNDDDNSNRITNNRSYDHSLEKYYKKAISIFKQPANANGENGNGANGHEDDDEDDEEISTNFAQRSGRLIESHNGFHYFVGSSSMTLFGLEIQSLVTKYISVKNFRPLPINTKNKILNSNLNPAISSFINSNNYLFSSYNFLNPISTIVNLNSINDNLSPLMFKIILKSDTDGSSGQEEVIQFQLPSYNYTKLLIDCFINYNDGCFYFFNEGLVKCGINKLYLENKWLYYDNTKKALDNENDPILQAVWFCKILLILAVGEMYLGSINNEMLKNYSNQPKLPGSKFFQMGSKIFNCLFSSERLENVTKKGGIEVLLLYAFFLQVADYTLASYFYFGQALRTCLILGLHVDSQSDTLSRYEIEHHRRLWWTVYMFERMLSSKAGLPLSFTDYTISTALPADIDDETIEEKNSHYVFRKAELISNCVTIVKINAQILSKLYQRQPETNIIITLKVVIKQLLEWRNNLSDSLQVDFTQKDEDFKISRLSTNMFTEYFQGINLAVRPLLFHFASIQLKRFKTSNTFVNLQNYSATISSLLTCSLHASVNTIRSLWSLLQNSMLAMFSYMDREYLFTSSCTLLLFNTAFGIHEQTLYHLDHSLEIFTQMRNLGNIPAGLRRAQLLTLMANLDFHGIMNDLITKYNDILKFDSMNCENDNIVEDSNEPKRETEKCKPHKDGDRIDPSIIDCDKSNTNTNMIKNESISNIVSILPEGAKPTLTDYSNGNNDVNDINVNNSEPSTFFDIITASLENSYQTTLTEKGSQVMEKNMDQLDSVHNLNDDDLQQLLEDLGNIDHSDEKLWKEITDQAMWLGNTMDPTAAAGSEIDFTDYLGP
The following text describes a protein:
Function:
During stationary phase prevents 70S dimer formation, probably in order to regulate translation efficiency during transition between the exponential and the stationary phases. During environmental stress such as cold shock or excessive cell density at stationary phase, stabilizes the 70S ribosome against dissociation, inhibits translation elongation and increases translation accuracy. When normal growth conditions are restored, is quickly released from the ribosome. Has been suggested to inhibit translation elongation by blocking the A-site (aminoacyl-tRNA site). Has also been suggested to inhibit translation initiation by blocking the A-site and P-site (peptidyl-tRNA site) of the ribosome. At 15 degrees Celsius binds 30S subunits and stimulates their association with 50S subunits into idle 70S ribosomes. Crystallization with T.thermophilus 70S ribosomes shows it binds in the channel between the head and body of the 30S subunit, where mRNA, tRNAs, initiation factors IF1 and IF3 and elongation factor G would bind; this protein's extended tail follows the mRNA channel and probably prevents RMF binding, which would prevent ribosome dimerization. This protein also stabilizes the 30S head relative to the rest of the ribosome, which may also prevent dimerization. Counteracts miscoding (translation errors) particularly efficiently at magnesium concentrations close to those observed in vivo but less efficiently at higher concentrations. Counteraction of miscoding was shown to be stronger than inhibition of translation, suggesting that the former activity could be the main function of this protein in vivo.
Sequence:
MTMNITSKQMEITPAIRQHVADRLAKLEKWQTHLINPHIILSKEPQGFVADATINTPNGVLVASGKHEDMYTAINELINKLERQLNKLQHKGEARRAATSVKDANFVEEVEEE
The following text describes a protein:
Function:
Appears to contribute to D.radiodurans capacity to survive exposure to ionizing radiation. Likely functions as a DNA damage-induced nucleoid-associated protein (NAP) that contributes to the enhanced level of nucleoid compaction after irradiation by bridging DNA duplexes, thereby limiting the dispersion of the fragmented genome immediately after irradiation to facilitate subsequent DNA repair. In vitro, binds both ssDNA and dsDNA, and is able to compact circular DNA, circularize linear DNA, anneal complementary DNA strands and protect DNA from nucleases.
Subcellular Localization:
Cytoplasm, nucleoid. Note=Is distributed all over the nucleoid shortly after irradiation, but after 2-3 hours, it forms discrete foci located at the sites of septal closure in between the newly segregated chromosomes of D.radiodurans.
Domain:
Is composed of two domains, an unusual N-terminal wHTH motif and a more classical four-helix bundle at its C-terminus, which is domain swapped in the DdrC homodimer. The domain swapping creates an asymmetric dimer exhibiting two distinct DNA binding surfaces corresponding to a high- and a low-affinity DNA binding site.
Sequence:
MKNAPLTLNFGSVRLPVSADGLLHAPTAQQQLGLTQSWEAALVEHGLPETYRDFGAGPEAAVSVPDFVALAFALDTPEARRWQKRARELLARAMQGDVRVAAQIAERNPEPDARRWLAARLESTGARRELLATVARHGGEGRVYGQLGSISNRTVLGKDSASVRQERGVKATRDGLTSAELLRLAYIDTVTARAIQESEARGNAAILTLHEQVARSERQSWERAGQVQRVG
The following text describes a protein:
Function:
Binds 7-ketocholesterol. Acts during spermatid development where its function is required prior to the removal of cytoplasm from the sperm head (By similarity).
Subcellular Localization:
Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Localizes to the equatorial segment of the acrosome.
Sequence:
MGKAAAPSRGGGCGGRSRGLSSLFTVVPCLSCHTAAPGMSASTSGSGPEPKPQPQPVPEPERGPLSEQVSEAVSEAVPRSEPVSETTSEPEPGAGQPSELLQGSRPGSESSSGVGAGPFTKAASEPLSRAVGSATFLRPESGSLPALKPLPLLRPGQAKTPLGVPMSGTGTTSSAPLALLPLDSFEGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQGEMAHTCRGTINLSTAHIDTEDSCGILLTSGARSYHLKASSEVDRQQWITALELAKAKAVRVMNTHSDDSGDDDEATTPADKSELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSLTELDGLKIPSESGEKLKVVNERATLFRITSNAMINACRDFLELAEIHSRKWQRALQYEQEQRVHLEETIEQLAKQHNSLERAFHSAPGRPANPSKSFIEGSLLTPKGEDSEEDEDTEYFDAMEDSTSFITVITEAKEDSRKAEGSTGTSSVDWSSADNVLDGASLVPKGSSKVKRRVRIPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPNIF
The following text describes a protein:
Function:
Has antibacterial activity against Listeria and Enterococcus.
Subcellular Localization:
Secreted.
Sequence:
MKSVKELNKKEMQQINGGAISYGNGVYCNKEKCWVNKAENKQAITGIVIGGWASSLAGMGH