lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.
Subcellular Localization:
Endomembrane system. Golgi apparatus.
Sequence:
MWEQSLSGLIKALRSSKDDEKRVIQQALSEIAQEVKSTDLDLKAAAILKLCYLDMLGYPQLSSYSFNVVECMSSNKFYIKQIGYLAASQSFGPNTEVSMLTTNLVKKDLVSHSSQPMSFLNLTNGNFNSTAPVLCLALSSLPHLLNSQNSADLSSDLVSMLNHSKPMIRKRAVTAIHTLASADMARMIEERGDLTRDQYAASADPASSKTMDIWVERFREKLLDDDIGVVSSTVNVICELASKEPWPWLELAAELYDLLKLKKNNWMMIKIVKIFTVLTPIEPRLTKKLLPALSDIISTTNAMSLLYECIHTILASGMLTHATSAEESYKLAKICIDKLAHFLDHVDQNLRYMALVGLNKLVPSHPELLEGYLETILELIHEVDPMLTIRALDLLEGIQYHSQTLKNTVDYLVNKLEGQKQHSTSEGTGQSDAVKALMSIQLSSKPSHLSPTLAPNHKLRIINVIITICSKSAYSHISDFNWFLEVLVRLIRLLVASQIEGTHTESNSSNTDGSHSVTRLANVLIDVSSRVRDIRPYAVNKMLSLLHDDTFLDNISNDYCYVTDIGSSAANSYGPDNEGASSASNLVTAAIWICGEYSDSGYVDLKDVISTLFKRQLILDNSSRLPQISTFALHNGLKVFVKWLREIVDSWYSEAHSDESYAEEEFQMAQNNSPKQSRVDVELGQLNRLVSAITDRARDLTKQKNSWASSNFFPTIDHVQLLDRANEVDRLMSLISRELIGYRPPTRPQMKVPEHQNEASHHAMYGMSSFGEANPFATSSGSPDEGFHRSMGDMNTSVDSSMTSSKTKQVQPPYWYKVLSDLFFVYELKPVANSAQAMIQAPDELDLDSWIPYLRDTSEQSHSCTGLDEFGRKIGEDFVNPYQSAASNGPFFDDPSIDPNFAPDSSRKRRAKKKKDPIDKEALAKARQDRIERQRDDPFYINTKTRKKQKEKGHGNGRTSTDLLDIDSIPIVKLDLSVSHDDPPTAGPSSISNSHRPHHLLKQTPSSSSSFSSASRTPVIDAEGEVPDLSYLQKYKTKRKEDGAQQKPVTALKTSSNQREHLNPNPPISLTPNDHTHTIVAHTPESIKVVKKKSSSKKKKKTDKNIVPVIN
The following text describes a protein:
Function:
The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGSQARYNMFKIFNPEGCVKQLDFIRQTTELGGTAVGLKNRSVGVLIAHNERRSRLADIQKKVFSIDRKSLFTFSGITNDGLQIVDYLIDKSVREEVIKGRAIHFLDVFEDLLRDVFERTILDGRRLYGVSGLYMTEYDGIRLVEFNPKGHVREVKGMGIGCRAQSSRTVLEAYCEEYEKMGVEELVRIGIMALKNAHPEDDALTGENVEIWILEAGKAVYNIDAKVFLN
The following text describes a protein:
Function:
Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source.
Subcellular Localization:
Cytoplasm.
Sequence:
MKFGESLQLALIPEFAEQYVDYNGIKRKIQLVAALPEDERKKLLRRNSDGSWPKGSIDEMLENDLQKVVNLFNTRIVQLDNYVTRLSTEKSPNTEITQALSSSYEAEEKAKQLKELDFRLQQLSSFCEWNKLAFEKLAANMDKHLGTERLVTFYEQKVCKLDFANSSKIYESMIALKALNSSQNDSEVKDKLEKLSIHHPLKKDLLAFIQLDIAAEVVTACINAPDSVLVDILAASIIAGAKACMREVIGRIGLRSECLASALRRAINNLCGPDEGVLYFLEVLKQICSVVYVDSYHSNRLLSRILLVERNSKGQSVMHSVAKLGWAGLCSKFCEIVSSIPDSEPLNWMLPCWRDVMHDTPLTLAIKGNHVEALHALLSAQDKETTSTKPGPVPPLVLTCCVGDYDLIVEELILAGFNPNEVDASSNTALHTAVRYNRPECVKMLLKLGANPSARDFLNSWTPLMLASATGLSEIVSILVASGASVDEVDSSGWTAMEQAVVRGYLHLADKLRTQVALSDKPVNLHTLYIKASSSEMRSRKRAMDLQLSRSVVIIRISDLAGRIRVSLQGDDAVYVSGRSPSFAASRPSSVDFMSQSTDSLSKNDTTASNGSMTPSSSQNNSVIIDIPRSHFDNAGEVCLENLAEPDEIADDSIHLHYDAAQENSPQPVNGSSPPYELVFVTRNTEEATITIDLLANRSHKILGRTVCCLTSLVSDLGNHMQSLKPLAPLPLLSSKTLKPIAHVNADVLISKVTVDDRFSSNDGISTPALSLEAVSNVSRTALEDAERSLHKSATTTSESGKSNGVAVIGHRGLGKNQPDRLSLQLGENTLQSFIKAADLGASYVELDVQMTKDMVPVVYHDFIVNETGTDAQVHSLTLEQFLGASHSPSEEIKDDASDIQQKRRPRAYSSSFTPSGSQVNFGEFAEENARLKPKVYKGNALGHTICAPFTTLKDVLKEVPQSVGLNVEFKYPMLSEAEEEKLLPIAYDYNFYVDTILSIIKKYGGKRKYIFSSFNPDICILLSLKSTNPVLFLTEGGTAYRTDVRAASLRQALKFASQWSFLGIVSACEPLIMCPRLIKAVKQLGLSCYTYGVLNNDVDNVRRQVRFGVDAVIVDNVLAIRRALNQYDESLESD
The following text describes a protein:
Function:
Both GamL and GamS bind to host RecBCD nuclease and inhibit its activities, protecting the viral DNA against RecBCD mediated degradation. Isoform GamS mimics DNA, preventing RecBCD from binding DNA. Expression of this protein in E.coli renders cells more sensitive to fluoroquinolone antibiotics (which inhibit topoisomerases and induce dsDNA breaks). Frameshift mutations that delete most of this protein (starting from position 78 or 97 of GamL) allow the bacteriophage to overcome the retron Ec48 bacteriophage defense system. Overexpression of the wild-type gam protein in E.coli with an intact Ec48 retron leads to a dramatic decrease in cell growth, the frameshift mutants do not have this effect.
Sequence:
MDINTETEIKQKHSLTPFPVFLISPAFRGRYFHSYFRSSAMNAYYIQDRLEAQSWARHYQQLAREEKEAELADDMEKGLPQHLFESLCIDHLQRHGASKKSITRAFDDDVEFQERMAEHIRYMVETIAHHQVDIDSEV
The following text describes a protein:
Function:
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Subcellular Localization:
Cytoplasm.
Sequence:
MEEDSRLPPGRKVLCLFDVDGTLTAARERRDPGLARAPVPPGQQDRTGQDGTGRDPSKIARQSPDPGDLAVKIIHKFDYVFAENGTVQYKDGKLISKQAIQNQLGEELLQDLINFCLRYMGLLKLPKKRWQPAVVPVQTACINSCDPLPVCAVSSQDENSREVRREKIREKFVATLQKEFAGKGLRFTRENLLKINDYTRSLDKPEKINSSTTKGLSDWRGLYYYRKERDIGGNDYEIFNDPRTIGFTVYSPTDTARLCRELFFSTPPAAP
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MARLILVWVALCAATVLASGSAVPPSAWSSRVHRTARDTMGDGRDHHAAAQPRSMLSCDRVNNFFSSINVTVSQGSQHDQGPVCGGICCDAETERQLQAKATKTFERLVKHHIRSQRGLWESAANVYKDYLLQLLQQSENKTLNLFSTVYRKMSPLSREPIRELYATIRQKLLADHAGDDFEMMTILFFRDLFPVAYHHAIHSDVHGTERGRPASAGNSNRDFHSDYKNCLVHTYDDLKPFGMVPQELSSSLVSSVSAASVLLRALREGAEVLLKLEEVGVSAPSCRQALLRMNYCGSCKRYNHLHAKPCAGLCQNVMRGCLIEFVGALNKGWSTLTEAIVPLIGTVRSVDGIETDIKSLDGKLSNAIMHAMQNGPQLEKQVEQACGVPSMMPSEYLADGSYDDAPQTLAGSSKWPLAPNNEMLQFEMTIDKNKDLFIQLSTTLCEDEDYHPTDEDCWTGSSLSDYTQQVVTTIGDRYNPEVVYNASATVSPHMQTLVDRLINLKTAVNKAYSSNTFRSDVDKMQSDMAEGSGDSYPSDDDEDGDLASGSGDDVNPRTIFRDNPNVTPSHTDVSAAKRISTSSCWSLITLVAVCLQVLLLSSDFCGH
The following text describes a protein:
Function:
Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions (By similarity).
Subcellular Localization:
Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=May associate with the cytoskeleton.
Sequence:
MIIKEYRIPLPMTVDEYRIAQLYMIQKKSRNETHGQGSGVEILENRPYTDGPGGSGQYTHKVYHVGMHIPGWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDTGENNNVFNLSPVEKSQLITDIIDIVKDPVPPSEYKTEEDPKLFQSVKTCRGPLSENWIQEYKKRLLPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWYGLTMEKIRELEREVQLMLSRKMAQFSEEGPSELSKDSATKDQASGTTSDPGSKNGEPLGRGLKKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDSDEGSEEEFFDAHENLYCTEEKQAKDMTKWNSNDLMDKMESPEPEESQDEIYQQSGSEFRVASSVEQLNIIEDEVSQPLAAPPSKIHVLLLVLHGGTILDTGAGDPSSKQGDTNTITNVFDTVMRVHYPSALGHLAIRLVPCPPICADAFALVSNLSPYGHDEGCLSSSQDHIPLAALPLLATSSPQYQEAVATVIQRANLAYGDFIKSQEGVTFNGQVCLIGDCVGGILAFDALCYSGQPVSESQSSSRRGSVVSMQDADLLSPGTLANAAHCSGGSGGGGSGGSSLESSRHLSRSNIDIPRSNGTEDSRRQLPRKRSDSSTYELDTIQQHQAFLSSLHASVLRNEPSSRRSSSSTMLDGAGALGKFDFEIADLFLFGCPLGLVLALRKTVIPSLDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHSLPPFSIPRYQRYPLGDGCSTLLADVLQTHNTVFQEHAAPSSPGTAPAGRGFRRASEISIASQVSGMAESYTASSIAQKGPSSLNHTPSIRRLSLLALPPPSPTTQGPRARARQVSPNLERAPCLPDLDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDSSSILELDGKEVSVFTPSQPRERWQRKRTHVKLRNVAANHRINDAVANEDGPQVVTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLHLDTLVTNSSGRVSYTIPETHRLGVGVYPIKMVVRGDHTFADSYITVLPRGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRAHAAYGSTKDVAVYNSISLSPMHIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYNHRARPARNTATRMALRKGSFGLPGQSDFLRSRNHLLRTISAQPSGPSHRHDRTQTQMDSEQRGQRSMSVAASCWGRAMAGRLEPGAATGPK
The following text describes a protein:
Function:
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
Sequence:
MFVPLQAYKDKSWQEYVLVFPVVSVGNAAQLAVDLLLSTLETELVGYIHSTALLPLVGGNPYRVGDQRLATACQVYVCHGSKLLLVQQRTPVSPNSRTEYRQFLTDWMKQERCRLVVMLSSCLSQYTDPWDLPKYSVHYYCSPAVTQQVQGDLGALCWNKLEKQDPVTHEQSSHGVLLMPGSGITRSLLEKCVSDEIPVVLLLVYCSEGDNTPDAILLADRLDEWLHLCQPLKDGEERCGRTGPWQTPISWSLLFGNTPPTGIY
The following text describes a protein:
Function:
Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MKAVLRSTTLLPSVARLQPREAAHLRHVSSTSSTSSSRAAALARAAEVSTTASERLAAGGPPMMGPSFTSRQDANKLDSAHRILSDHDQASAHLNLSSSQARRSRAARFGTSRHTTYSPSSFVSGSAAEEQEGRDRLALAYASPTGTSTSSIYLPEYVVWAISQLITAANDPKLLRSDHLKLAHLTDPQEHMAEAAHIPPKRSSLLHLATVSPHRYAAILAVLSEVHQRLSTSALTEGNSADLETALPRWTPDTVLDFDCAAGEGLWAAAHVFRQDDTDPHSPTSVHQYYGFDRRPNLLKSGKKVAQSSSSNVSPAEPTKAGREVRLKDEGEEIVVDGITYYEQEDSVPQQDAEAELQEATEASDEPALEYFAGPKSAMAPVWKKFQSVPLAHDLASIGSSRSLALSAFALSLMTNDSNRFEAVQAMWDSGAQVIVVIDQATPRGFASVASARAQLLQLGKSSEGSHVVAPCSHDKPCPLLHPFTISSAVASAVGARSDTGNPAKSNDVCAFTARYHTPTFLRRTKHSDRGEENVGYSYVVVRRGSRPSLVGEAQRRLDAAERGQNQDGLEEMVEQLTVEAGKTKAGILDLLRNAKKASSERKTLLEVDSTEELISSEQLIAADADAGPMEAEAEMSDSQAMDELLRMLPDAIKAEHTASANNDSIDSLSSSLTPEQLDSIMASVRSTLSSSTIGSTSATPASIEVSEDDSTALTLSAPSASSELAMRLESYAWPRLIRSPLKKGGHVTLDACCATGNIERFTISKACGKQAYQDARKAKWGDLFPHSSRSRNVIKVLNPVTALEMQGEAAQLENLTLRAPSKLTTTRSASNPARFDVIGIDSDQDANSILAELFDDMPDLVPSKLSNVDRALASYRLISPNLITPTKKQIKRLNINYAQKWNTISTAKAAKLANIKTNVNTRQPLPSPPALDAQDDGADAFTSSLQSAGRGEKRVKETRSSRKKSRGDWDQELFGA
The following text describes a protein:
Function:
RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. May be involved in poly(A)-site recognition. May be involved in the association of the CPF, CPFIA and RNA polymerase II complexes (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MLNYQCLETDSYCGTSHIELDGIHIYIDPGSDDSLKHPEVPEQPDLILLSHSDLAHIGGLVYAYYKYDWKNAYIYATLPTINMGRMTMLDAIKSNYISDMSKADVDAVFDSIIPLRYQQPTLLLGKCSGLTITAYNAGHTLGGTLWSLIKESESVLYAVDWNHSKDKHLNGAALYSNGHILEALNRPNTLITDANNSLVSIPSRKKRDEAFIESVMSSLLKGGTVLLPVDAASRVLELCCILDNHWSASQPPLPFPILFLSPTSTKTIDYAKSMIEWMGDNIVRDFGINENLLEFRNINTITDFSQISHIGPGPKVILATALTLECGFSQRILLDLMSENSNDLILFTQRSRCPQNSLANQFIRYWERASKKKRDIPHPVGLYAEQAVKIKTKEPLEGEELRSYQELEFSKRNKDAEDTALEFRNRTILDEDLSSSSSSEDDDLDLNTEVPHVALGSSAFLMGKSFDLNLRDPAVQALHTKYKMFPYIEKRRRIDEYGEIIKHQDFSMINEPANTLELENDSDDNALSNSNGKRKWSEINDGLQQKKEEEDEDEVPSKIITDEKTIRVSCQVQFIDIEGLHDGRSLKTIIPQVNPRRLVLIHASTEEKEDMKKTCASLSAFTKDVYIPNYGEIINVSIDVNAFSLKLADDLIKNLIWTKVGNCEVSHMLAKVEISKPSEEEDKKEEVEKKDGDKERNEEKKEEKETLPVLNALTLRSDLARAPRAAPLLVGNIRLAYLRKALLDQGISAELKGEGVLLCGGAVAVRKLSGGKISVEGSLSNRFFEIRKLVYDALAVV
The following text describes a protein:
Function:
Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
Sequence:
MGNFLKNKKIILGITGSIAAYKIYELIKLLKDAEADIFPVMTEKATYFVTPLSIEISCGNKVLIDMFEEPLSHIELAKKADIFLVAPATANLINKYASGIADDLLTTTLLAFKGHVIIAPAMNWRMYQSPQVQKSIEYLKNLGVKFVGPEEGLLACGEEGAGRLASINKIFESVVSAITEKDLEKEHIIITAGPTRQYIDTIRFITNKSSGKMGYALAKIAKRKGAYVTLISGPSTIEPPEVDRFIRVETTSEMLNQVMGNINKATTLLMAAAPLDFEPKKIFKTKIEKKSIKSIPLKLCPDILIEVSKLKKKPFTVGFAAEAGLNTERAKIKLREKSLDMIILNDIMQKDRGMESDTNEVLIIYRKGNKFFEEKTPLMSKEEIASIILSKIREIKLGK
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSEIIRYCKGILQRGVLESCKTLYYTGELKYGTLVGVDKFGNKYYENKEEIFGRHRWVEYGDYKNPDPTTIPPEWHSYIHFISDRPGSEMLSFAPTYKRPHIANPTGTDGAYTPPNFLFNIEKSKEELEKEQKEKK
The following text describes a protein:
Function:
Has chemotactic activity for porcine, and in a lesser extent, for human neutrophils.
Subcellular Localization:
Secreted.
Sequence:
MRLLTSRATRVPSPSGLLCAVLAMLLLTPSGPLASASPIEAAEAAVVRELRCMCLTTTPGIHPKMISDLQVIPAGPQCSKAEVIATLKNGKEVCLDPKAPLIKKIVQKMLDSGKKKN
The following text describes a protein:
Function:
Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine, a mutagenic oxidation product of adenine in DNA, and of isocytosine. To a lesser extent, also catalyzes the conversion of 5-fluorocytosine (5FC) to 5-fluorouracil (5FU); this activity allows the formation of a cytotoxic chemotherapeutic agent from a non-cytotoxic precursor.
Sequence:
MSNNALQTIINARLPGEEGLWQIHLQDGKISAIDAQSGVMPITENSLDAEQGLVIPPFVEPHIHLDTTQTAGQPNWNQSGTLFEGIERWAERKALLTHDDVKQRAWQTLKWQIANGIQHVRTHVDVSDATLTALKAMLEVKQEVAPWIDLQIVAFPQEGILSYPNGEALLEEALRLGADVVGAIPHFEFTREYGVESLHKTFALAQKYDRLIDVHCDEIDDEQSRFVETVAALAHHEGMGARVTASHTTAMHSYNGAYTSRLFRLLKMSGINFVANPLVNIHLQGRFDTYPKRRGITRVKEMLESGINVCFGHDDVFDPWYPLGTANMLQVLHMGLHVCQLMGYGQINDGLNLITHHSARTLNLQDYGIAAGNSANLIILPAENGFDALRRQVPVRYSVRGGKVIASTQPAQTTVYLEQPEAIDYKR
The following text describes a protein:
Function:
Catalyzes the attachment of tryptophan to tRNA(Trp).
Subcellular Localization:
Cytoplasm.
Sequence:
MSKKRVLTGVTTTGIPHLGNYVGAIRPAVRAAQNLDTESFLFLADYHGIIKCHEPEMIHQSTQAVAATWLACGLDPERTTFYRQSDTPEVMELNWILTCITAKGLMNRAHAYKAAVQANAENGQEDPDFGVEMGLFSYPILMTADILMFNANEVPVGRDQIQHVEMARDIAGRFNHRFRELFTLPEVKIDENVELLVGLDGRKMSKSYGNTIPLWENDKKTQKSVNKIITNMKEPGEPKQPDESPLFEIYKAFSTPSETVEFTKMLADGLAWGEAKKLLAAKINAELAEPRERYNELTADPSQIEEILQAGAAKARKEARELLDKVRDAVGIRPLK
The following text describes a protein:
Function:
Could possibly oxidize fatty acids using specific components.
Sequence:
MAQYDPVLLSVDKHVALITVNDPDRRNAVTDEMSAQLRAAIQRAEGDPDVHAVVVTGAGKAFCAGADLSALGAGVGDPAEPRLLRLYDGFMAVSSCNLPTIAAVNGAAVGAGLNLALAADVRIAGPAALFDARFQKLGLHPGGGATWMLQRAVGPQVARAALLFGMCFDAESAVRHGLALMVADDPVTAALELAAGPAAAPREVVLASKATMRATASPGSLDLEQHELAKRLELGPQAKSVQSPEFAARLAAAQHR
The following text describes a protein:
Function:
May be involved in pre-mRNA splicing.
Miscellaneous:
MISCELLANEOUS: Present with 3260 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSTATIQDEDIKFQRENWEMIRSHVSPIISNLTMDNLQESHRDLFQVNILIGRNIICKNVVDFTLNKQNGRLIPALSALIALLNSDIPDIGETLAKELMLMFVQQFNRKDYVSCGNILQCLSILFLYDVIHEIVILQILLLLLEKNSLRLVIAVMKICGWKLALVSKKTHDMIWEKLRYILQTQELSSTLRESLETLFEIRQKDYKSGSQGLFILDPTSYTVHTHSYIVSDEDEANKELGNFEKCENFNELTMAFDTLRQKLLINNTSDTNEGSNSQLQIYDMTSTNDVEFKKKIYLVLKSSLSGDEAAHKLLKLKIANNLKKSVVDIIIKSSLQESTFSKFYSILSERMITFHRSWQTAYNETFEQNYTQDIEDYETDQLRILGKFWGHLISYEFLPMDCLKIIKLTEEESCPQGRIFIKFLFQELVNELGLDELQLRLNSSKLDGMFPLEGDAEHIRYSINFFTAIGLGLLTEDMRSRLTIIQEVEDAEEEEKKLREEEELEKLRKKARESQPTQGPKIHESRLFLQKDTRENSRSRSPFTVETRKRARSRTPPRGSRNHRNRSRTPPARRQRHR
The following text describes a protein:
Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MVNPTEETIKAVLESCGMKAAMSFVGGGVLGAGMGVFFASMDVSMPYSVPGMQVPGQPSFEERSNMTTRETIRSMGRQLGSRAWSYGKSFAFIGFMFAGSECLIESHRAKHDSVNTAGAACFTGGIMGLRAGPTPALFGCATFVAFSFVMDQLLGGAGFDAPSKPENTDTTLTAPSGAAPIAAQ
The following text describes a protein:
Function:
Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.
Sequence:
MKNLISIIIILCLTLSIMTPYAQATNSDVTPVQAANQYGYAGLSAAYEPTSAVNVSQTGQLLYQYNIDTKWNPASMTKLMTMYLTLEAVNKGQLSLDDTVTMTNKEYIMSTLPELSNTKLYPGQVWTIADLLQITVSNSSNAAALILAKKVSKNTSDFVDLMNNKAKAIGMKNTHFVNPTGAENSRLRTFAPTKYKDQERTVTTARDYAILDLHVIKETPKILDFTKQLAPTTHAVTYYTFNFSLEGAKMSLPGTDGLKTGSSDTANYNHTITTKRGKFRINQVIMGAGDYKNLGGEKQRNMMGNALMERSFDQYKYVKILSKGEQRINGKKYYVENDLYDVLPSDFSKKDYKLVVEDGKVHADYPREFINKDYGPPTVEVHQPIIQKANTVAKSMWEEHPLFTIIGGTCLVAGLALIVHMIINRLFRKRK
The following text describes a protein:
Function:
mRNA-specific translational activator of cytochrome b. The cytochrome b (COB) leader RNA may represent the target sequence for CBS1 and CBS2, tethering the COB mRNA to the inner mitochondrial membrane, where cotranslational insertion of cytochrome b into the membrane can occur.
Miscellaneous:
MISCELLANEOUS: Present with 556 molecules/cell in log phase SD medium; MISCELLANEOUS: CBS1 protein devoid of mitochondrial targeting sequences can enter mitochondria in vivo, possibly due to a bypass of the mitochondrial import system; MISCELLANEOUS: The in vitro imported CBS1 protein is functional and soluble indicating that the N-terminal part of CBS1 confers some binding to mitochondrial membranes.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein.
Sequence:
MLRTKVFATTVARISGIRRYIPIRTINTVTKKNISKIEKLCEVLEVNPDGYKGKERIPTKELTKLLYTTSRNMLVRVPMTGDLSTGNTFETRNETLQKLGEQLIHLEINKMLTITFTNFNQFNIMNKNFNYIHNLDRARVVNMDSISWLIKNSLKINQLAHLRIPANLPKEMGLTSSSNDFQNLNDWKVILSFIGYLKLLEIKNDNKKFIESIIKTICIPLINYHLRKS
The following text describes a protein:
Function:
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MALGSVQMEGKEEGSLQSIRYSPGRLELLDQQRLPHESVYLDINNTESGWIAIKDLVVRGAPAIAISAALSLAVEVSNLKSFDGTSTDAASFLVKKLEYLVSSRPTAVNLSDAATRLKEIVLKAATDGNAESVFQAYIEAAEAMLVDDVRSNKAIGKHGADFIMNQHKDSKKLSILTHCNTGSLATAGYGTALGVIRALHAEGVLETAFFTETRPVNQGSRLTAYELVHDKIPATLITDSAAAALMKAGRVDAVIVGADRIAANGDTANKIGTYSHAISASYHGVPFYVAAPFTSIDLSLTSGDQITIEERSAKELTHARGGQGEQVVVNGISAWNPAFDVTPASLITAIITEKGVITKASANDFKIRDFIH
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MYFVGSETKPTIRVVKKVQLGILSPDEIRKQSVTAGGIKYPEIYEGGKPKLGGIMDPRQGVTNRSARCQTCDGNMNECPGHFGHIDLAKPVFHVGFFEKTIEILRCVCYYCSKLLVSPNNPKLQEIFLKSEDQPGKRMALVHELCKGKNICEGGDQIGEDEPITEDMVGHGGCGRSQPSISNRQLEIIAKWKNLDIVSGAKKLVLTAEHVLAIFKRISDEECAILGMDPKYARPEWMIISCLPVPPPNTRPPVMNGSEHDYLTRKLVDIVKVNNELQRNEQSGAEDPIIANNIKMLQFNIAMLSNSIKNRLEGKKGRIRGNLMGKLVDFSARTVITPDPNLRIDQVGVPRIIAQNMTFPEIVTSFNIEKMQELVQRAKSQITFILMIIGKQLFTLIIPGNVNMMRTHSTHPDDEDEGPYKWISSGDTKVMVENGELVMGILCKKTLGASAASLLHIIFMELGHEVCGQFYGNLQTVINNWLLYEGHSIGIGDMLAERLTYLNIQATIQNAKEDVIEVTQNSHNDELEPTPGNTLRQTFENQVLRIIYDAQEQASDLAKNSLKGYNNLKAMAVAGSSGSSITTSQAIACVGQQNVEGQRIPFGFRKRTLPHFIKDDNGPESRGFVENSYLTGLTPSEFYFHAMAGRELLIYDARIKSETGIIRQLVKSMESVMVHYDGTVRNSAGRLLQFSYGEDGLAAESVELQKMPTVKLSNSVFEKKFKFDPSNENYVRRIFNEEITRELISSAEVITEIEHEWEQLYKDREALRQIFPTGENKVVLPCNLQRMIWNVQKIFHINKRAPTDLSPLRVIQGVRDLLAKCVIVVGEDKLSIQANQNATLLFQCLVRSTLCSKRIAEEYRLSSEAFEWLIGKIETRFQQAQAQPGEMVGALAAQSLGQPATQMTLNTFHFAGVSSKNVTLGVARLKEIINISKSPKSPSMTVFLRGEAATDAEKAREVLCRLEHTTLRKVTANTAIYYDPDPLNTVILEDQDFVNFYYEMGDFDPTRISPWLLRIELDRKRMTDKRLTMEQIAEKVYTMFGNAVKCMF
The following text describes a protein:
Function:
Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (By similarity). The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces (By similarity). The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules (By similarity). The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase (By similarity). In the complex, it mediates interactions with microtubules (By similarity). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MEAFMVSFERQKDAKFCMYRENIPNFESTLSSITKSTNSIKILLEDISNVQKVITDPCEQSCSSCSPNVLNKFLGIEEKLVNNVEIPDSVPQKSTRPCLDDEKEGSSVVQPPESGNRHVQLISEQEFKSIPKYQLGRLTLDNLNEIVGKMDEFLTKKNAILGKTNKQITRQDREVLDNWRELEIKAKGRLPTTLFFIENDIRPLLTERLRLSFAKAIPCLRHIRRVREERCGPLTFYYA
The following text describes a protein:
Function:
Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
Sequence:
MENKATDFSGKWRMKSSENFEELLKALGVNVFLRKIAVAAASSPAVEIAQQGDNLSIKTSTSVRTTHVSFTVGQSFSEATVDGRPCTSFPKWETDRKISCEQTLLKGDGPKTSWTRELTNDGELILTMTAGEVVCTRVYERE
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MLALRRSVHGACAAHAARAGSSLIPQHVEPIVTSSTRSFQSLGLNASLTDRLAQMGLATPTTAQCKAIPSILAGEDVVVAAETGGGKTLSFLLPLVEQLRRNPLPPSEMRLPAALVLTTSQELVRQLAAVLHQVDPELARLAVSLSSSRQTLGQHGSRACPVVLATPGALLRATKPRDFAFTQMVVVDEADMLLSGGFEKETKQILATIRNQPLLRSELNSCTETEPKDREFADADFSAERTQTIFSAISFLRFDGGDGVGFHRTLPQLTLNAHNLQEFVANGDFMDEQHARCELLYQILTSSGRSADASAGEKTLVFTNSIASADALFDFLENDKGVANCALYHKEVDRPQRQKLLQRLDSEADADKDLVVICTDIAARGLDTTKVSHVVQFEFAGDVVSYLHRIGRTGRAGTSGTVTSIESSENSLVLTKIREAGSSTLQNAFSRKRSLRKKFKKALRPGNDDY
The following text describes a protein:
Function:
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISQVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCMRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIRKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFSELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSVSSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHTGRCDLTSHASAQADGKALKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISPASIELSALEMGGLAPSQALEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPLPLSSSATMPSMQCKHRSPNGGLFRQSPVKTPIPMSFQPVPGGVLPEALDTSHGTSI