lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).
Subcellular Localization:
Cytoplasm.
Sequence:
MRDMLSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKVKAHKRCAVRAMNNCKWTTLSSIGKDIIEEEDGVIAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWRCLWCREVVHSSCKAHYPAKCPLGHCRLSIIPPTALNSMSSDGYWQASKNGCGSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNDGPHIGLRLFQNFDTFRILVCGGDGSIGWVLSEIDKMELHKQCRIGVLPLGTGNDLARVLGWGTACDDDTNLQVILEKLEIASTKMLDRWSIWTQEMPMAHAEEVTPGEPVEGDNKMGEVGLDAESHREKEMISSYEDSVATHLAKILHSDENTEVISSAKVLCETVKDFVEKIGHAYEEGGSHSKDAQIMKEKCNLLNEKLNLLLQTLKVEAQATPIPPGSILPIITAAAAAAVTTTTTTSGGGMGTPTILPRSPSFHGSEKHLEESQEKDVCESKDGVGDGDILEQMMGPSTSSRVFKPRDALMSRANSLKKAVRQIIEQTEKAVDEQNAQTEEQEAKTIKAIAATAAAAITSATTQGPIKPKVTIVTPSSDLEMSDDDNNQSAKVPDSSGSTKEDPQGGSRSPFSIYVSSTKAKIEKKKAERIGLKSPRSPFRMRRISHGSTLSSHHGFGPVGVSQKFGSMENISILPGLDTLLGPSLGRTNPMLSKSIGTLAGGMGGAGIISKVLLANADALCAAASPLMDQDTEKVEGFSESCVMNNYFGIGLDAKITLDFHNKREEHPEKCRSRTKNIMWYGMLGTKELVHRTYRNLEQKVQLECDGQRIPLPSLQGIVVLNIPSYMGGANFWGTNKEDETFTAPSFDDKILEVVAVFGGMQMAVSKLITLQHHRIAQCRVVKITILGEEGVPVQVDGEAWVQPPGLVKILHKNRAQMLVRDKHFESTLKSWTERRKIERPLQPLINEEIEVVRHFCGTTSQLIDTIKIAAQHSSPIQSELLHKAMATAACQERLFSTERSTEGMSRKVLNEVVVSARNLYSESSLFMARKAYALRLPENILEALNHDINAVDNELRKVSTIEGAVCYVEEEGHHHHSHIPVDVYRKHTKGKFKIPMVSRFKKPTKKDFKSSGVTGGLSVVKLWTVEEVGAWLEALLMGEYKDQFIRNDIRGSELLSLERRDLKDIGVTKVGHIKRIQQAIKDLDKREVIEPTVLEAGPSGSVAL
The following text describes a protein:
Function:
The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such as activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10 (By similarity).
Subcellular Localization:
Secreted. Nucleus.
Sequence:
MRPGALWPLLWGALVWAVGSVGAVMGSGDSVPGGVCWLQQGKEATCSLVLKTQVSREECCASGNINTAWSNFTHPGNKISLLGFLGLVHCLPCKDSCDGVECGPGKACRMLGGRPHCECVSNCEGVPAGFQVCGSDGATYRDECELRTARCRGHPDLRVMYRGRCQKSCAQVVCPRPQSCLVDQTGSAHCVVCRAAPCPVPPNPGQELCGNNNVTYISSCHLRQATCFLGRSIGVRHPGICTGGPKVPAEEEENFV
The following text describes a protein:
Function:
Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons. Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy. Lipid transfer protein required for lipid droplet degradation, including by lipophagy. Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown. May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis.
Subcellular Localization:
Cytoplasm. Lipid droplet. Midbody.
Sequence:
MATKTDDAPAKIKSYHDEGFRYINQGLECDEKGKNKEALQLYRKGVRSLVTGSSIYCRGSGKQYDDARQKQEKMKLAKEQVEERISALSSLDRASTNSSAKTGPPGEVEHATPDNGMWEDVNELLVLENAVKMFFVSEQGHVTTISQPQTLRAYQFIMYEEGCEQPPAFLQCSGWMFPMIPKRSPVLNTEPHTYMFPDITISASKSVQRPGSFASVGLILNPETPSSDMNRFERILRCYTDYHHYTPTPDDYQEIQAVSGTNQPAEYVASKSVAARPLPGAIRGQTQTEEEKGTWGEKVSKGILVGAELIAWGLMKGAQVGSHLVYKGGIKIRQNLRPNESPTEVDEKVQENIRHVKSVAGNMQRYLPESIGIPGNMQRYLPESIVIPGNMQRYLPESIGIPGNMQRYLPESIGIPGNMQRYLPESIGIPGNMQRYLPESIVIPGNMQRYLPESIGIPGNMQRYLPESIDTGWSSGPFSFRQKDCVLPDSVKSKTDNEKGEKVMQEAVKVAVTGAHGFASIYQSLETSWRMLYTSLQLATVETVDHKYGPAVGEATNNSMGALGFALQTAWNVDNLGVKALAKRTAKDTGKHMIKEAEKRYIVSADDQLARQ
The following text describes a protein:
Function:
Serine/threonine kinase which acts as a component of the MAP kinase signal transduction pathway. Once activated, acts as an upstream activator of the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases. May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis. Involved in phosphorylation of WNK4 in response to osmotic stress or hypotonic low-chloride stimulation via the p38 MAPK signal transduction cascade.
Sequence:
MESGGGNAPAGALGAASESPQCPPPPGVEGAAGPAEPDGAAEGAAGGSGEGESGGGPRRALRAVYVRSESSQGGAAGGPEAGARQCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAVVDMSDVSRQPSLFYHLGVRESFDMANNVILYHDTDADTALSLKDMVTQKNTASSGNYYFIPYIVTPCADYFCCESDAQRRASEYMQPNWDNILGPLCMPLVDRFISLLKDIHVTSCVYYKETLLNDIRKAREKYQGEELAKELARIKLRMDNTEVLTSDIIINLLLSYRDIQDYDAMVKLVETLEMLPTCDLADQHNIKFHYAFALNRRNSTGDREKALQIMLQVLQSCDHPGPDMFCLCGRIYKDIFLDSDCKDDTSRDSAIEWYRKGFELQSSLYSGINLAVLLIVAGQQFETSLELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFSVSMLAHDVGKAVQAAERLFKLKPPVWYLRSLVQNLLLIRRFKKTIIEHSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVYQPSYVSINNEAEERTVSLWHVSPTEMKQMHEWNFTASSIKGISLSKFDERCCFLYVHDNSDDFQIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDTLEYEYDHDANGERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSVSPDSDAQPDALFERTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQGLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQSSEELHLSVGHIKQIIGILRDFIRSPEHRVMATTISKLKVDLDFDSSSISQIHLVLFGFQDAVNKILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELRAHFEPTCETEGVDKDMDEAEEGYPPATGPGQEAQPHQQHLSLQLGELRQETNRLLEHLVEKEREYQNLLRQTLEQKTQELYHLQLKLKSNCITENPAGPYGQRTDKELIDWLRLQGADAKTIEKIVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQEASETKDKA
The following text describes a protein:
Function:
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MDEITITTQPKSGYVIRNKPLRLQCRANHATKIRFKCSSKWIDDSRVEKQIGTDSTSGVGYVDASVDISRIDVDTSGHVDAFQCQCYASADDDQDVVASDIATVHLAYMRKHFLKSPVAQRVQEGTTLQLPCQAPESDPKAELTWYKDGVVVQPDANVIRASDGSLIMSAARLSDSGNYTCEATNVANSRRTDPVEVQIYVDGGWSEWSPWIGTCHVDCPLLRQHAHRIRDPQSVLPHQRRTRTCNNPAPLNGGEYCKGEEEMTRNCKVPCKLDGGWSSWGEWSACSSSCHRFRTRACTVPPPMNGGQPCFGDDLMTQECPSQLCTADSSRIVISDTAVYGSVASIFIVASFILAILAMFCCKRGGKKSRSSKTLKMTPEKSGGIYYSEPPGVRRLLLEHQHGTLLGEKISSCSQYFEPPPPLPHSTTLRSGKSAFSGYSSTRNAGSRAALIQECSSSSSGSGGGKRTILRTSSSNCSDDDNYATLYDYMEDKSVLGLDTTQNIVAAQIDSNGARLSLSKSGARLIVPELTVDGEKMLYLAVSDTLSDQPHLPPLESALSPVIVIGQCDVSMSSCHHDNILRRPVVVSFRHCASTFPRDNWQFTLYTDEGAGWQKAVTIGEETLNTNMFVQFEQPGKKNDGFGWCHVMTNSLARLMLAGHPRRNSLSASKRVHLAVFGPMEMSSYRRSFELRVYCVPETGAAMESVWKQEDGSRLLCESFDFILNEKGNLCICIEDVIPGFTCEGPEVVEISETQHRWVAQNGLHCSLKFRPKEHNPPPFSTRVIVYQKASSTEPMVMEVSNEPDLYDATSEEREKGSVCVEFRLPFGVKDELARLLDMPNESHSDWRGLAKKLHYDRYLQFFASFPECSPTSLLLDLWEASSSGSARAVPDLLQTLRVMGRPDAVMVLERFLSAFPQIISP
The following text describes a protein:
Function:
Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.
Sequence:
MAGTDMDPEVARGLFEEGATLVLLGVPEGTELGLDYKTWTLGPRFRGVKMIPPGLHFLHYCSVSTNGGCGEISPKTGLFLSLKPRQVLVAHWNKSADDLEISQNSEEVERVRGNLKELDRYLGPYPYDTLRKWVSLTDRLSQEVAVALQPLSGRVCAFSDVIPELQLTHTKDRVQQNLSRNDQECQSMKEGLDRLPRMKQREGTELRFSSIPKQAYPPGATPAQITQYSMDRSYILNAVLERHYKEQPLNVLGELQFAFVCFLVGNVYEAFEHWKSLLALLCRSEEAMKDRKELYLGLIAVLYHQLGEIPPDFFVDIVSQSNFLTSTLQDFFQFASSPGVDSTLRKRAEKFKVHLTKKFRWDFDADLDDCAPVVVELPDGVTVD
The following text describes a protein:
Function:
Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes (znuACB).
Sequence:
MEKTTTQELLAQAEKICAQRNVRLTPQRLEVLRLMSLQDGAISAYDLLDLLREAEPQAKPPTVYRALDFLLEQGFVHKVESTNSYVLCHLFDQPTHTSAMFICDRCGAVKEECAEGVEDIMHTLAAKMGFALRHNVIEAHGLCAACVEVEACRHPEQCQHDHSVQVKKKPR
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MVKEEQEEPEPPMIEEQEEPGPPMIKEEHEEPEPPEIKEEQEEPEPPEIKEEQEEPEPPLIKDEQEEPKPPMVKEEQEEPEPPIINEEQEEPGPPMIKEEQEEPEPPEIKEEQDEPEPPEIKEEQEEPEPPVIKKEQEEPEPPVIKEEQEEPEPPVIKEEQEEPQPPMIKEEQEEPQPPMVKEEQEKLCISKDEEQLDMKQETDTFMEIPIHEENQNNEADLKEQQIFNVNDCQDEEGNQHEESLSTTNGHTHPKNREQRKRKDKRPVQNVDSSHKKTHTGEKDFTCKECEKSFTRKSILKMHMRIHTEEKDFTCKECDKSFISKSNLKMHMRIHSGERPFSCKECDKSFISKSNLNMHKVIHSEERPFSCKECNKSFTKKPNLKTHMKIHSGERPFSCKECNKSFTSKRNLKIHMRIHTGEKPFFCKECDKGFRQISHFKTHMRNHREEKPYSCKECDARFDFVSGLERHRRKHTGEKPFSCKDCKKSFKRKCNLKIHMRIHTGERPFLCKECNSSFTFENGLKIHMRNHTGERPYSCKECDKSFIQMCELKAHMITHTGERPFVCKECDKTYFQMSALKAHMRTHTGERPYSCKECAKSFRQRSHFRTHMRTHTGEKPFFCKECDKSYIQMSDLKAHMRTHTGERPYSCKECDKSFRQRSHFRTHMRTHTGERPYSCKECDRSFRYGYGLKRHIRIHAGEESFSC
The following text describes a protein:
Function:
Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cell membrane; Single-pass type I membrane protein. Virion.
Sequence:
MALPYHIFLFTVLLPPFTLTAPPPCRCTTSSSPYQEFLWRMQRPGNIDAPSYRSLSKGTPTFTAHTHTPRNCYNAATLCMQSNTHYWTGKMINPSCPGGLGATVCWTYFTHTSMSDGSGVQDQAREKHIEEVISQLTRVHSTSSPYRGLDLSKLHETLRIHTRLVSLFNTTLLGLHEVSAQNPTNCWMCLPLHFRPYISIPVPEQWNNFSTEINTTSVLVGPLVSNLEITRTSNLTCVNFSSTIDTTNSQCIRWVTPPTRIVCLPSGIFFVCGTSAYHCLNGSSESMCFLSFLVPPMTIYTEQDLYNYVIHKPRNKRVPILPFVIRAGVLGGLGTGIGGITTSTQFYYKLSQELNGDMERVADSLVTLQDQLNSLAAVVLQNQRALDLLTAERGGTCLFLGEECCYYVNQSGIISEKVKEIKDRIQRRAKELQNTGPWGLLNQWIPRILPFLGLLAAIILLLLFGPCIFNLLVKFVSSRIKAIKLQMEPQMQSMT
The following text describes a protein:
Function:
Probably causes a marked increase in hemolymph carbohydrate.
Subcellular Localization:
Secreted.
Sequence:
MNPKSEVLIAAVLFMLLACVQCQLTFSPDWGKRSVGGAGPGTFFETQQGNCKTSNEMLLEIFRFVQSQAQLFLDCKHRE
The following text describes a protein:
Function:
Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MNQSNASMTVIGAGSYGTALAITLARNGHQVVLWGHDPKHIATLEHDRCNVAFLPDVPFPDTLHLESDLATALAASRNILVVVPSHVFSDVLRQIKPLMRPDARLVWATKGLEAETGRLLQDVAREALGDQIPLAVISGPTFAKELAAGLPTAISLASTDETFADDLQQLLHCGKSFRVYINADFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLTEMSRLGAALGADPATFMGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVKGAQDKIGQVVEGYRNTKEVRELAHRFGVEMPITEEIYQVLYCGKNAREAALTLLGRARKEELSRH
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MASATRFIQWLRNWASGRDLQAKLQLRYQEISKRTQPPPKLPVGPSHKLSNNYYCTRDGRREAMPPSIVMSSQKVLVAGKPAESSAVAASEKKAVSPAPPIKRWELSQDEPYL
The following text describes a protein:
Function:
Plays a key role in the control of the eukaryotic cell cycle.
Sequence:
MEKYEKLEKVGEGTYGKVYKAKDKATGQLVALKKTRLEMDEEGIPPTALREISLLQMLSHSLYIVRLLCVEHIDKNGKPILYLVFEYLDTDLKKFIDSHRKGPNARALPTALIQSFLFQLCKGVAHCHSHGVLHRDLKPQNLLVDKEKGILKIADLGLGRAFTVPMKSYTHEIVTLWYRAPEVLLGSTHYSTAVDMWSVGCIFAEMVRRQALFPGDSEFQQLLHIFRLLGTPTDKQWPGVSSLRDWHVYPQWEPQNLASAVPALGPDGVDLLTKMLKFDPSDRISAKAALDHPYFDSLDKVSVEVGVRVRADLVLGSGLELGSWAELVLGLGLEPKRPTITLNSITLEDLAVSVDAARFKVNFNVTMNGSVSIENPNRVSFQYEDINPYIEYGGQEIGDVHIPAGNIGARTTTTMNFTLMIMADKISSNPNLFSDVVEKGMLQLTLYVKLKGKVKLNVLFKIKFKVSSKCDLSLDIRNGTLANQSCHSKIKL
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTCGYMRDVATANTWTFFKLLFRWKGSVWKSIHMELIVWLFVFVNIRNAYEFFILGSSAAETYEHIVHRCREISGKCRTMMTFAIGFFVTYVSTRWWSIFMTIPWPDTCALQLTAFLRARGKKYEQEDRLFRQNIMRYLWLSYVLVFRDVSVRIKKRFPSVKSMTPTLLTQEELTKLKTSSKEMRPWVPIEWILDYLRSAKKKCLLDELHYIELNQTVLAYRQQLHEILSHDCITVPLVYVQSVHICTICYFVITCFSAQTIHSDHKSWEGVIDFYLPVYAVIEFIVFVGWLKTAFVMLNPFGMDDDDFEMNALIERNMMVSLSYINDFYDKPPKLVDMKVRLPTNLQEVVRENANPMHGSAVPVKMSRVHEAMADDPQFANLLNSVLPSARDSTTAFQTHRPINEFPNIAKSAAMGIISTDDEKSDRGAYRNPENSSKDDGGAAGELRSKFLKQEDFEAAVKKVLDKKLAEEREEKEEKEEKKEEKKEEKLKSLSPEPTQRSWYQEEPTQKTWVGPDEGPSVLQKKISKIRPRPSKADVRLSTTTQNASTRKPLSTYKKASGAATPSTLTSPQAPKTSAEAELKLDNTQSGEK
The following text describes a protein:
Function:
Hydratase involved in the degradation of sialic acids. Catalyzes the reversible conversion of the dehydrated form of N-acetylneuraminate (Neu5Ac), 2,7-anhydro-N-acetylneuraminate (2,7-AN), to Neu5Ac. Also catalyzes the irreversible conversion of 2-deoxy-2,3-didehydro-N-acetylneuraminate (2,3-EN) to Neu5Ac. The reaction mechanism involves keto intermediates and the transient formation of NADH.
Miscellaneous:
MISCELLANEOUS: Bell et al. show that this hydratase allows the growth of E.coli strain BW25113 on 2,7-AN as a sole carbon source. However, Kentache et al. show that it allows the growth of E.coli on 2,7-AN and 2,3-EN, which are produced during the degradation of sialoconjugates by sialidases from other bacteria, provided the repressor NanR has been inactivated.
Sequence:
MINYGVVGVGYFGAELARFMNMHDNAKITCVYDPENGENIARELQCINMSSLDALVSSKLVDCVIVATPNYLHKEPVIKAAKNKKHVFCEKPIALSYEDCVDMVKACKEAGVTFMAGHIMNFFNGVQYARKLIKEGVIGEILSCHTKRNGWENKQERLSWKKMKEQSGGHLYHHIHELDCVQHLLGEIPETVTMIGGNLAHSGPGFGNEDDMLFMTLEFPSGKLATLEWGSAFNWPEHYVIINGTKGSIKIDMQETAGSLRIGGQTKHFLVHETQEEDDDRRKGNMTSEMDGAIAYGHPGKKTPLWLASLIRKETLFLHNILCGAKPEEDYIDLLNGEAAMSAIATADAATLSRSQDRKVKISEIIKHTSVM
The following text describes a protein:
Function:
Probable non-lysosomal thiol-protease.
Sequence:
MAYNQESSVETSIIKFKDQDFTTLRDHCLSVGQTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHFILDGISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILRVQSFSHQYAGIFRFRFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHKNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLMGGVITNIHLHSSPVDLVKAVKTAIKAGSLITCATPSESTDTAQAMENGLVSLHAYTVTGAEQIQYRRGWEEIISLWNPWGWGETEWRGRWSDGSQEWEETRDPRKSQLHKKQEDGEFWMSCQDFQQKFVSMFICSQIPITLDHGNTLHEGWSQIMFRKQVILGNTTGGLRNDAQFNFSVQEPMEGTNVVICITIAITPPNLKAENEKLPLNFQVIPAGSQRFQEKFPPVFSSPFGNVVQSSNNKFRRNFTVTYHLSPGNYVVVAQTRRKSVEFLLRIFLKMPDNDRHLSHHFNLRMEGSPSEHGSQQSVFNRYAQQRLDIDATQLHSLLNQELLTGPPGDMFSLDECRSLVALMELKVDGRLDQEEFARLWKRLVHCQHVFQKVQTSPGVLLSSDLWKAIENTDFLRGIFVSRELLRLVTLRYSDGVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLYLTEMEWMNLVMYN
The following text describes a protein:
Function:
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
Sequence:
MSQNTIHKIAVKKRTTTGKNENNRLRSSGMVPVNIIGGGVATSGAVNEKELEKMVHSGIRQSTLIELDVEGQGAQKVFVKEIQRFPEIDRIRHVDFYKVVPGQKIVTKIGIETTGIAKGSKTGGQFEHIIHEIRVKTIPEDLLENLTIDVTDLDVGDSIKISQLKVPTSWEILINGDPIVTSVNKTKALLAAERAEAKGSAADDAKAKKGKK
The following text describes a protein:
Function:
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Subcellular Localization:
Cytoplasm.
Sequence:
MSEAVTRIQVGGTAGSEPYEVLVGRQLLGELGGLIGAKAKRVAVIHPEALAETGDALRADLAAQGYEAIAIQVPNAEEAKTAEVAAYCWKALGQSGFTRTDVIVGVGGGASTDLAGFVAATWLRGVRWIAVPTTVLSMVDAAVGGKTGINTAEGKNLVGSFHPPAGVLCDLAALDSLPVNDYVSGLAEVIKAGFIADPAILDLIEADPQAARTPAGPHTAELIVRSIKVKAEVVSSDLKEAGLREILNYGHTLGHAIEKNERYKWRHGAAVSVGMHFAAELGRLAGRLDDATADRHRSILEAVGLPLHYRYDQWPKLVENMKVDKKSRGDLLRFIVLDGLAKPTVLEGPDPAVLLAAYGEVGE
The following text describes a protein:
Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Zona pellucida. Cell membrane; Single-pass type I membrane protein.
Domain:
The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
Sequence:
MGFSNTLAWFISVFLIAECFSRVHHGPHHHRGGSSVSQQLLSTQFQAAVPQFQAAVSQFQAAVPKFQAAVPQFQVTIPQIKETPLTDPVPPQAVIVYCRAEAIELVINPDLLAGGLPVFAEELWLGPEASPTCGVVSTGPGPLTIRASLQDCGTQLSVNADSLLYSNVVVYSPLPSPDGVIYTNGAAIPVQCQYRRRYSVDSAAVRPAWVPFDASVSATDYLDFSLRLMTDDWQFERGSNVFFLGDEIHLQAAVRLAYHLPLLVFIDWCVATPTPDVDASEVKYSFIKHHGCLADSRSPNSNSMFMRRTEGNHLNLQLDAFRFHKFTGNLVYIHCHMKAIPAAYSVSAKNRACSFIDQRWRSVDGNDDVCNTCEPSKPVGSEPEQLFHIALTSPVQQPNLAPKPGPAGFFNVRPGQSVEPFNALIQSKSPAFGGLSKRGTDSNKEWMKFATVGPLLLKSKQETSVQSAGGPRFGLDNVFAASFVEKPVFNFTEMRPVEDELEPAPRFRSFSPLQKSIFNVSDLFNSEGSGFE
The following text describes a protein:
Function:
Odorant receptor.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNFDSFFSFLLKLLIMALSNSSWRLPQPSFFLVGIPGLEESQHWIALPLGILYLLALVGSVTILFIIWMDPSLHQPMYLFLSMLAAIDLVLASSTAPKALAVLLVRAQEIGYIVCLIQMFFTHAFSSMESGVPVAMALDRYVAICHPLHHSTILHPGVIGPTVIGHAYCEHMAVVKLACSETTVNRAYGLTVALLVVGLDVLAIGVSYAHILQAVLKVPGSEARLKAFSTCGSHVCVILVFYVAGMFSFLTHHFGHHVPHHVHVLLAMVYLLVPPALNPLVYGVKTQKIRQRVLRVFTQKD
The following text describes a protein:
Function:
Part of a major quorum-sensing system that regulates the development of genetic competence. Involved in the maturation of the competence pheromone ComX. Acts by catalyzing the transfer of a farnesyl group on the ComX pheromone. Shows weak geranylation activity with geranyl diphosphate (GPP).
Miscellaneous:
MISCELLANEOUS: The DNA sequences encoding comQ, comX and the N-terminal two-thirds of comP show a striking polymorphism, which determines the specificity of the quorum-sensing system in the different pherotypes of Bacillus.
Subcellular Localization:
Cell membrane.
Sequence:
MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGENLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSIYSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGVLLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDASEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLDKEKKELIKECLLSYTKGDTRCKT
The following text describes a protein:
Function:
May be involved in the regulation of smooth muscle contraction by transporting polyunsaturated fatty acids (e.g. arachidonic acid).
Sequence:
KLVDTANFDDYMKALGVGFATRQMAGLTKEISFKLDEEFDETTADDRHVKKLILTLTMGNVVSTRTYPTTI
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MNYGSSTPRRLAAVPESVELDSFATSLLWQSSYRDTIRSVSIGAGRSARFYPRSDGDAERASSFSSSASSTSLLAASYSGSGLSSTDGMSSFRGWGTAGFNGVHELRGIALQMLNDGYIRGIIQAFSGGSSVEANGGGPDHEKLIVERWLSELDVEWILHLGANSAVGQGWSESPSIFMEEGAERRRGAIMAREMEDEEPLLGSPTTSSTLHTGEGKGEDMVQLHLDLDLDLESLRDLMERWIRALLVMVHVLFITYLELRAKRSTVGGVRTVRKTIRYIQMLIGVATPGATGETASSQEEEVTLFARFAEVSVLRMLTFVDAVCHAVPTYYWAPEALPGMLQVYACVADASPTVLALFKQAASSTTVFEGMNAAFLRKRTNLSNTIWSLMGMVRASFFTEDCCRISLESSGPGVHETTRLMMNYIALLWSNQGALNLVLQDHHFSVFVSEDEGFNSVVSLIIDMISSLEKHLVDASHSIAEHGLRYIFLMNNCDFITQQVRSLDLPAWFPSDDSKIQGYIDAYLHASWTPVLSCLYVDIPFGPRRYASLSKFESQFNTICDSHRLWKVPDPELRKRLRKAIIEKVIPWYARYLEQRAATGRRTTSRSSTPHQLQEVLEELFEG
The following text describes a protein:
Function:
Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAGISYVASFFLLLTKLSIGQREVTVQKGPLFRAEGYPVSIGCNVTGHQGPSEQHFQWSVYLPTNPTQEVQIISTKDAAFSYAVYTQRVRSGDVYVERVQGNSVLLHISKLQMKDAGEYECHTPNTDEKYYGSYSAKTNLIVIPDTLSATMSSQTLGKEEGEPLALTCEASKATAQHTHLSVTWYLTQDGGGSQATEIISLSKDFILVPGPLYTERFAASDVQLNKLGPTTFRLSIERLQSSDQGQLFCEATEWIQDPDETWMFITKKQTDQTTLRIQPAVKDFQVNITADSLFAEGKPLELVCLVVSSGRDPQLQGIWFFNGTEIAHIDAGGVLGLKNDYKERASQGELQVSKLGPKAFSLKIFSLGPEDEGAYRCVVAEVMKTRTGSWQVLQRKQSPDSHVHLRKPAARSVVMSTKNKQQVVWEGETLAFLCKAGGAESPLSVSWWHIPRDQTQPEFVAGMGQDGIVQLGASYGVPSYHGNTRLEKMDWATFQLEITFTAITDSGTYECRVSEKSRNQARDLSWTQKISVTVKSLESSLQVSLMSRQPQVMLTNTFDLSCVVRAGYSDLKVPLTVTWQFQPASSHIFHQLIRITHNGTIEWGNFLSRFQKKTKVSQSLFRSQLLVHDATEEETGVYQCEVEVYDRNSLYNNRPPRASAISHPLRIAVTLPESKLKVNSRSQVQELSINSNTDIECSILSRSNGNLQLAIIWYFSPVSTNASWLKILEMDQTNVIKTGDEFHTPQRKQKFHTEKVSQDLFQLHILNVEDSDRGKYHCAVEEWLLSTNGTWHKLGEKKSGLTELKLKPTGSKVRVSKVYWTENVTEHREVAIRCSLESVGSSATLYSVMWYWNRENSGSKLLVHLQHDGLLEYGEEGLRRHLHCYRSSSTDFVLKLHQVEMEDAGMYWCRVAEWQLHGHPSKWINQASDESQRMVLTVLPSEPTLPSRICSSAPLLYFLFICPFVLLLLLLISLLCLYWKARKLSTLRSNTRKEKALWVDLKEAGGVTTNRREDEEEDEGN
The following text describes a protein:
Function:
May act as a regulator of myogenesis. Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs.
Sequence:
MSRSNRQREYKCGDLVFAKMKGYPHWPARVDEVPEPNAKSSANKYQVFFFGTHETAYLGSKDIFPYEETKEKYGKTNKRKGFSEGLWEIENNPTVKSSGHQPSRKRSSTTKAGRGGGAKNSGKAARKKNLEEDEDADADAEEKEEADSEKKGNAEGSSDEEGKLVIDEQSKEKSDKTANKRKAEDTAESSPKKAKVEDDKEPEKNEKEESNEEERVQTPEAGKEKNREPPKPAEDSGKEKVEEKPAVGEETKEQKESL
The following text describes a protein:
Function:
Transferred from the ejaculatory bulbs of males to the female genitals upon copulation, plays an important role in the reproductive biology.
Subcellular Localization:
Secreted.
Sequence:
MNYVGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRGRDNGSYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLVGEEDCLTVSVYKPKNSKRNSFPVVAHIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIFENFVRDVEMRPDEQIISRNFINMLADFASSDNGSLKYGECDFKDNVGSEKFQLLAIYIDGCQNRQHVEFP
The following text describes a protein:
Function:
Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Subcellular Localization:
Periplasm.
Sequence:
MAAIPWRPFNLRGIKMKGLLSLLIFSMVLPAHAGIVIYGTRIIYPAENKEVMVQLMNQGNRSSLLQAWIDDGDTSLPPEKIQVPFMLTPPVAKIGANSGQQVKIKIMPNKLPTNKESIFYLNVLDIPPNSPEQEGKNALKFAMQNRIKLFYRPAGIAPVNKATFKKLLVNRSGNGLVIKNDSANWVTISDVKANNVKVNYETIMIAPLESQSVNVKSNNANNWHLTIIDDHGNYISDKI
The following text describes a protein:
Function:
Part of the multicomponent carbazole 1,9a-dioxygenase (CARDO), that converts carbazole (CAR) into 2-aminobiphenyl-2,3-diol. Acts as a mediator in the electron transfer from CarAd to CarAa.
Sequence:
MNQIWLKVCAASDMQPGTIRRVNRVGAAPLAVYRVGDQFYATEDTCTHGIASLSEGTLDGDVIECPFHGGAFNVCTGMPASSPCTVPLGVFEVEVKEGEVYVAGEKK
The following text describes a protein:
Function:
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein.
Sequence:
MSHRKNKAVGLAAFDRSRLTSAQYATHGSALRSSQASALETQLSVFRSLLQQFAATHAKDIKSNPTFRAQFARMCAAIGVDPLLASSGHGDSKGKGDSMWAQLLGRTVNDFYFELAVRVVEVCGETRGENGGLIEVGMVRERVVKGRVEGMGVQGVTEDDILRAVGTLKPLGSAYSVIKVGSKQYIRSVPKELNTDQSAVLEAAQVLGYVSVSMLMDNLRWTRARAQTALEDLVGEGMLWVDKQGIEWEYWSPGFMLEGDLPLDGFD