lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Has alanine:glyoxylate aminotransferase activity.
Miscellaneous:
MISCELLANEOUS: Present with 339 molecules/cell in log phase SD medium. Expression levels higher in stationary phase than in exponential growth phase when grown in complex medium with glucose.
Sequence:
MTKSVDTLLIPGPIILSGAVQKALDVPSLGHTSPEFVSIFQRVLKNTRAVFKSAAASKSQPFVLAGSGTLGWDIFASNFILSKAPNKNVLVVSTGTFSDRFADCLRSYGAQVDVVRPLKIGESVPLELITEKLSQNSYGAVTVTHVDTSTAVLSDLKAISQAIKQTSPETFFVVDAVCSIGCEEFEFDEWGVDFALTASQKAIGAPAGLSISLCSSRFMDYALNDSKNGHVHGYFSSLRRWTPIMENYEAGKGAYFATPPVQLINSLDVALKEILEEGLHKRWDLHREMSDWFKDSLVNGLQLTSVSRYPSNMSAHGLTAVYVADPPDVIAFLKSHGVVIAGGIHKDIGPKYIRIGHMGVTACNKNLPYMKNCFDLIKLALQRKK
The following text describes a protein:
Function:
Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
Sequence:
MKASRVLAAAAARVGPAMRKQVLTLTEEAASRVHHLLRQRQKPFLRLGVKARGCNGLSYTLNYAAVVYGLISVSIASDEKGKFDELVEEKGVRILVEPKALMHVIGTKMDFIDDKLRSEFVFINPNSEGQCGCGESFMTTSTSSSAKQS
The following text describes a protein:
Function:
Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA. Essential for growth. Directly binds H/ACA snoRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKDNKEHKESKESKTVDNYEARMPAVLPFAKPLASKKLNKKVLKTVKKASKAKNVKRGVKEVVKALRKGEKGLVVIAGDISPADVISHIPVLCEDHSVPYIFIPSKQDLGAAGATKRPTSVVFIVPGSNKKKDGKNKEEEYKESFNEVVKEVQAL
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity).
Subcellular Localization:
Endosome.
Sequence:
MQKLADFKLPQFFNYPPYFTLQPVRDTREKQIQLWKELILDYCKSQKIFLIGVEEDFPLFSNSAIDRSLSHEARETFLSAIVGEGRAEWLDKGHRKCLILWHRIQDWADIVLQFVRDNGLEDSVMTVEEIRSGTESLGTELQGIDRTILMRALKLLENKGKLALFKGTSADDEGVKFSV
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MPRYKLTIEYDGAPFFGWQVQDTLPSVQGALEAAVKAMTGADLRVHGAGRTDAGVHARGQVAHVDIEKQFPPGRFRDGLNAHLRPHPIAVLEAEIVPDTFEARFSAVKRHYRYRIVNTRANLALDIGHAWRVPRRLDSDAMHAAARRLLGKHDFTTFRDTECQAKSPEKTLDQLDVLRDGREITIITSARSFLHSQVRSMVGSLVWVGEGRWTADDLSAALAARNRAACGIVAPPDGLYLVKVDY
The following text describes a protein:
Function:
May regulate T-cell apoptosis.
Subcellular Localization:
Mitochondrion.
Sequence:
MFCHLRPLRRFGLRKVLPHWLHYSRALSGAEAINALRPFYFAVHPDFFGQHPREREVNENSLKRLSVYLENLQKPGFKSLKPTQLTFYIREKTAQNSSEGQEPISTTGFRAVRFTLHSSDLLSTVLYILNSCSLPVEHVQSLNTNVHSQPLKEATGMPDRPIKWHRSYYSFTGFKDPDEDLTHVSRVETTLTSWLGSNGKGAVKKLRNSLPLRKELDRLKNELSELLQLSDIRWQRGWGVAHRCSQLHSLSRLAQQNPGPLQNVKGCTVVFTDRSGMSALGHVMLGTMDVHHHWTRLFESLPSYFDLQRRMSALEAQISNLLGGIQVVYIEELQPALTLDQYYSLLHTFYNQLLRSRVPPHPHPQSLSGLQMILSSDRYAPSLHELGHFDIPALSDPASLQSFMRTKAQQARENMTRREKLKVMENELIQASTKQFSLEKLYKEPSISSRQMVDCCKRLLEQSLPYLHGMHLCVSHFYSVMQDGDLCIPWNWKKGEAMK
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MLYLEDYIELIEHLPSDLRERFTDMREMDLQVQNSVDSLDDKVKKLFQKCFMKKTKITGADQVYEEIRNEYYKALEDADEKVQLANQIYDLVDRHLRKLDQELSKFKMELEADNAGITEVLEQRSLELDNPQSQQRTSLQKERRKHAVGGTPHTSTSNTVTINNGDGPPEKKIKSEQILKSELLAHLQDNSNLEYTTKVLNEVAEIGGREVAGFPIHYHEVENEMKENQSSAQPTRRTSLVKHEIKIESRTSEYDRISVDSLDANEQVSDSSICSATGGAVHRPFRAKKQTSKAAAWVQQRQQAEARLEQRKKETATVTDSNDPGVEVIGESSNVEWNFDPNEPRYCLCNQVSYGEMVGCDNDKCPIEWFHYGCVGLEQAPTGKWFCPQCTQTMKRRNKNK
The following text describes a protein:
Function:
Promotes unequal transmission of alleles from the parental zygote to progeny spores by acting as poison/antidote system, leading to poisoning of progeny that do not inherit the allele. May possess DNA nuclease activity that leads to spore killing, and a kinase activity that confers resistance to the nuclease activity. Can suppress meiotic drive by the P.anserina SPOK2, SPOK3 and SPOK4 proteins.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSDKDRIAQLLRELEEAKARVEEAKAREAQERCEKERLQLEHRKTTFLEYLRNCHRHLYNALRLTDTSRSSTGYTKVVGKYYPKRLRPWTNFANVLHPRYFDLVQKICGQRQLFEPASTTKNLGTIISDHLAGNEKAIDRFEVDAVERPVQAILKVLATHEEAGKAYRCPEFRFSANLRELTQEDDGSSGADDNTSDGSLERRQQAGPNKRPTSKRKYICSNRQPDGVGIRMQPGGGQTQAFIYDYKAAHKVAIEHVRSATAKEHLFHEVVARINDNKLSRDKEVQRREQAEAFIAMALTQVFDYMITYGVSYGYVAAGRCLLLLYVDRDDWQTLYCHPCLPADDVGEPTNDWTDRLSHTAVAQLVSFCLSSFQSEALEGQSLETALSVANATLKTWSESYADVAYLGLEPAELSSAPSSQNTDISEYTSKAKPTGRNVALRSQSSCKPAAVLPQGNEHDEHDEDHSEPGASRSRLAANKRKRGPSSGGEDEDIAMADPEPTRQYCTQACLLGLKRGKDLDENCPNVSLHRFDGSSRHPVNAHRFTDMVKQQLLLSPYKGCRMVDFWGKRGAMGWLFKLELFPYGYTFVGKGTLEDRLSRLEHEGRVYARLDHLQGDVVPVHLGLVRLDRGYILPGLEFVVYMMLMSWAGQTPSASMADAETLKRESLTAIWSEGVDHGDDNRANYLWNAERCRIMIIDFDRARLFPPLKPRAVSRLSKPKRERGNRSRHQIRT
The following text describes a protein:
Function:
Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate. Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes. Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release. PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MDVRFYPAAAGNALSGDPSNLDFTQCLDYYSYKFGNNNYMNMTEANNAFLAANETFHTPSLGDEEFEIPPITPPPETDPALAMTDVLLPFQVLGEALAAQGNGFTPQFPPQSLDLPSITISRNLMEQEGVLHNNGLSLDQHQAQMSQYRQDHSLIMRSLAHMTDAVRAGIMPPSQLTTINQSQLSAQLGLNIGSTAIPHTSPSPPASKSATPSPSSSVNDEDVDETNRIIGEKRGAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKRKTEAAKKEYLKALAAYRASLVSKAAAESAEAQTIRSVQQTLASTNLSSTLLLNTSLSQHAAMSMESQNLQQSIPRAIAPKPLTMRLPLNQIVTSVTIAQNMQSKIGTPLMSSVGAPMVATHPSQVSPTLQSQQHQIQQLQQQQQLHQMQQQQLHEHQMHQQIQQQMQQQQFQQHMQQQLQQQQQQQLQQQMQQQLQHIHLQHMQQQQMQHIQHQSQLSPQQQSPAGSQSGVPAQIASPIPHINSPSPASQHHQHPQAQTQLLSQVSIF
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMDRINHKKFINTTKLLLWCDQTIGLITFDINTPSFKLSKIRSFLNITASAVLLPFAIYHIFMHIVPTKLISFYKSTAILEIAFEVIFIVTVWMTGAVKHSKIAHFLNKMIRLDERFQSVGLQIDTVREKRRIKIHFFLRSLFAIMLPLGILLISQDVIANVLLFIFIVVKSGVAFQTIEFVSIIRNRFVILNRYIEESISKYKHAELVMPLCKSCDLHHRLSKLIKQLNATYGLILLLMFTSHFIFIVVSIFYMSAYLISNPIMWDRVMLLTFWSAFFIVNVLYICNQCYNTVEETKQTKKIIHKIQSENMTVMDVVEMFSQQIESHNICFTAVGFFRIDHTLLSTIVGGATTYFIILIQLSSSLLPNDPKNTTS
The following text describes a protein:
Function:
Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTATGNVEAKVLCFYRRRDISNTLIMLADKHAKEIEEESETTVEADLTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSVKTLLADKGEIRVGPRYQADIPEMLLEGESDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHSMDTLYRHGYDLSSAISVLVPLGGPVLCRDEMEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTYKPNPNQISTSNGKPGAVNGAVGTTFQPQNPLLGRACESCYATQSHQWYSWGPPNMQCRLCATCWLYWKKYGGLKMPTQSEEEKLPPSPATEDPRVRSHMSRQAMQGMPVRNTGSPKSAVNTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVPINYAAIRAEYADRHADLSGSPLKSKSTRKPLACIIGYLEIHPSKKPNVIRSTPSLQTPTTKRMLATPNHTSLSILGKRNYSHHNGLDERLMK
The following text describes a protein:
Function:
Cell wall protein which mediates cell-cell and cell-substrate adhesion. Required for biofilm formation and plays a role in virulence.
Subcellular Localization:
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.
Domain:
The N-terminal domain mediates haploid invasive growth and yeast cell-cell adhesion; The regions containing tandem repeats are required to project the N-terminal region into the extracellular environment and to mediate adhesion to polystyrene and to host cells. In allele CaO19.8979, the N-terminal tandem repeat region is expended and contains up to 90 repeats and the C-terminal tandem repeat region has one more repeat.
Sequence:
MKVSQILPLAGAISVASGFWIPDFSNKQNSNSYPGQYKGKGGYQDDCGDDYKKGYKSKTYSKVKPITSTDCTTPIQPTGTTTGYTKDVVESTSYTTDTAYTTTVITVTKCDGGSCSHTAVTTGVTIITVTTNDVITEYTTYCPLTSTPATESTPATESTPATESTPATESTPATESTPATESTPCTTSTETTPATESTPATESTPATESTPATESTPATESTPATESTPATESTPATESTPCTTSTETTPATESTASTETASSTPVESTVIVPSTTVITVSSCYEDKCSVSSVTTGVVTISSEETIYTTYCPITSSITIPVPNTSTPAAPGTPVESQPVIPGTETTPAAPGTPVESQPVIPGTETTPAAPGTPVESQPATTPVAPGTETTPAAPGTPVESQPATTPVAPGTETTPAAPGTPVESQPVIPGTETTPAAPGTPVESQPATTPVAPGTETTPAAPGTPVESQPVIPGTETTPAAPGTPVESQPATTPVAPGTETTPAAPGTPVESQPVIPGTETTPAAPGTPGTEATPVTTQPVSVLSTSQVVTASGEFSTVTAHSTSIVASCPEGGCVPEGQQTETSPSVPTNGPEVEASSSVLSIPVSSVTTSTIASSSETSVPPAQVSTFEGSGSALKKPYYGLAVAALVYFM
The following text describes a protein:
Function:
Together with the minus end-directed microtubule motor KAR3, involved in spindle midzone assembly, karyogamy (nuclear fusion) during mating, and with an essential function in meiosis I. To contribute to spindle midzone assembly during mitotic metaphase, the KAR3-CIK1 motor cross-links anti-parallel microtubules to align them on the spindle axis; as the motor travels polewards splayed microtubules are pulled into alignment. During the karyogamy (nuclear fusion) step of mating, KAR3-CIK1 cross-links antiparallel cytoplasmic microtubules emanating from the spindle pole bodies of mating partners; the motor activity of KAR3 creates the force that pulls the nuclei together by sliding cross-linked microtubules past one another. KAR3-CIK1 promotes microtubule shortening predominantly from the microtubule plus-end. Required for interhomolog recombination, synapsis of homologous chromosomes and establishment of a meiosis I spindle.
Miscellaneous:
MISCELLANEOUS: Present with 98 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton. Note=Localization to the spindle pole body is infrequent in meiotic cells. Localizes to cytoplasmic microtubules during mating.
Sequence:
MNNSKIPKLSFHSDPNNVTRDFPKTKRQKVQKREMDMILTPNNNKLNILHSSGSGIRRCYTDDTSATYTKKLTFGGDPKIIERVKNNERKVRKDIDSLLNAISEIEKESVRIHARELPAITLELDAKVKACRELQNEIDGLSTEMDLKDNQCDLQRKNVELSSKNIVSMHAVKVQEFENDLEEELSNAKREWTYKLMEVENLKPDERLTDEMRQLKTEFEEVNRKLFILQNENENECKNYKKELDKKFEIFKKVKNDARIELDGEQERLSKVLKDLQDTHGELKENIKTCRDEFNDFEKRIGEAEVNFHSMELAVVPLKKKLASTSQALTQVQEEKKQVEGEANNWKKKYVNELEKVQQELYTRQNLATSIEEIKGYTRCFAYANERQMPDEFHINYVDRCICENSGEKRVQVFDRVVLEEIHKDHKRLYNECIPFLEKYISKLINCSIIVVSQQPTAPMKKTLLKQLIEQYGENYKMTLNILHLDGSIKHSDVGLDNPTEIRDLSQDEECMNILTLDTKLGKDEESHSMNIYIGSMSTVQLNRELDDAPSVLSHILTKTKQCFVFKINAGENIEKALALAGKLKRTITLPQLD
The following text describes a protein:
Function:
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Sequence:
MICLPVVEDSVEKAIKTAEKYLEIADIVEFRIDMLKEVSEEDIEKFAKYPCIITVRADWEGGYWKGNNEERLNLIKKAIECNAKFVDIELREEKNKELVKFRDEIGSKTKIIISYHDFEKTPSKEKLVEIVEKALSIGDIAKFATMANSKEDVLNILEVINKYPGKIIGIGMGEKGKLTRILGVYFGSILTFASYKGKSSAPGQVDIDTLKEIWRLMDLK
The following text describes a protein:
Function:
Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MLLNSLLKLLQRQTYTCLSHRYGLYLCFGGLLLLVVSALQFGEVVLEWSRDQYHVLFDTYRDNIAAKSFQNRLCLPMPIDVVYTWVNGTDPELVTQLQEVREQMKERQRAFREFLGRNKTEPTKRSNKELECLLTHCIKVPMLILDPPLPANTTLKGLQASQPVFSSAVKVFHVAQPKNPSTNVTVIAFETIHEAENAQVNALFDNRKETIWRGYMTTDKEAPGLVLIPDLAFLSGFPETYKETDQLRAKLPETLSSKIKLLQLYSEARVALLQLNNPKDFQELNIQAKKNMTVEGKELTLSSAYLLWDLSAVSQVKQDEDISASRFEDNEELRYSLRSIEIHAPWVRHVFIVTNGQIPSWLNLDNPRVTIITHQEIFLNTTHLPTFSSPAIESHIHRIPGLSQKFIYMNDDVMFGTNVWPDDFFSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCLGNTAAGRFPPAVPGGLLNGQQWQPGIGISGVSYCNQGCANSWLADKFCDQACNVLSCGFDAGDCGQDHFDEMYKINMYLNKTHYIVPKGEHLPYFSFDSMAKKVLDGVYSDSHIVRHASAANKWKTIHLIMYPGMNATLVHFNLTFLSLSDTEIKMQIVIDVDTRDEHKQNITSASSKKAAMLTTPTPEAEILFEDIPEEKRFPRFRKYPPVTDMRLDIRIPTINLSRLPNEVQLALQNLNQNLKNGDITIKGFNLSRLSLLEPYWSLADPRDQSLNDNTHNKGNILLNERDNKTLTEHEIDPKSRLDKRVADIVNDKESHASKSISPIKRLTDLLHRESQMTKAALQKDAIERSENIAVVPGRMLQEYQPNYKGFLPWEKFKYFQDLLDEEAALLSDLSYITSSKHVGRKLQDTFADSLRYVNKLLNSKFGFASRKVPAHMPHMIDRIVMQDLQDLYPEAFDKTSAHKVRHSEDMQFAFSYFYYLMSAIQSLNISHVFEQADTDRSGVLSDREIRTLATRIHQLPLSLQDLTGLEQMLINCSKSIHYNSTDKGVVPPTQESYYDPNLPPITKVLVLSCKPVTDLIRKAYKDKNKYRFEIMGEEDIAFKMIRTNVSHVVGQLDDIRKNPRKFICLNDNIKHNHKDAQTVKAVLRDFYESMFPTPSQFELPREYRNRFLHVQELQDWRTYRDKLKFWTHCVLGTLIVFTVVSFFAEQLIALKRKIFPRRRMQIEGSPERSKV
The following text describes a protein:
Function:
Catalyzes the oxidation of L-aspartate to iminoaspartate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSVGIIGGGIAGLTAALSLAKLGYEVTLIHTGINTTNSYLAQAGIAFPLLEGDSITAHVIDTMRGGKYINDKETVWNVISKASEAYDFLLSLGVKFETNETEGGHSFPRVFTIKNETGKHLTKILYLHAKEGGVNFIKGEAEELAVKHGKAYGVFVNGEFLKFDATIIASGGFTGLFKYTAGSPTNLGTLIGDAVMKGAFARDLEFIQFHPTGFIGEDGVKLISEAVRGAGARLVTEDGKRFVNELSTRDIVARAIYLKMQEGERVFLDATGIADFKKKFPQIYAFLRKEGIDPSRDLIPIAPIAHYTIGGIAVDTWYRTGIKNLYAIGEAASNGFHGANRLASNSLLECIVSGLEVARTIVRDKPKGREVKEPPYHGYETGDIESLREILWGHAGIVRNERTLKEGLKKLRDVEADPRLKLLVRGVLECALAREESRGAHYREDFPAMRKEFERPSFFDGKCRL
The following text describes a protein:
Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MGDQIARGEEFEKKAEKKLSGWGLFGSKHDDAADLFDKAANCFKLAKSWDQAGAVYVKVANCHLRLDSKHEAAGAYANAAHCYKKTNTREAISCLEQAVHMFLDIGRLNMSARYYKEIAELYEQEQNLEQAIIYYEKAADLFQSEDVTTSANQCKQKIAQFSAELEKYQRAIEIFEEIARHSVNNNLLKYGVRGHLLNAGICQLCKGDVVAINNALERYQELDPTFSGTRECKLLVDLAAAIDEEDVAKFXIYQDALRTTLLLRVKEALKAKELEEDDLT
The following text describes a protein:
Function:
Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Also a central component of the condensin II complex, a complex that seems to play a role in prophase chromosome condensation. Both the condensin complex I and II play a role in meiotic and mitotic chromosome segregation. Plays a role in robust cytokinesis upon the presence of chromatin obstructions.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to condensed chromosomes during mitosis and meiosis. Localizes to chromosomes in a faint speckled pattern during prophase, then appears in two stripes outlining each chromosome during prometaphase. During metaphase, localizes at the poleward face of the condensed chromosomes. Dissociation from chromosomes is observed in late telophase.
Domain:
The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with mix-1, forming a V-shaped heterodimer.
Sequence:
MPPKTSAAPPQSDESDSDFDDAPVKKPQKKTTKPVNRHKEGSKDPEEELQRAVNEKFDGSDGEDDDSDLFSLQLPSRPDFLTKPNRADRLMIRNVEVDNFKSYFGKASIGPFHKSFTSIIGPNGSGKSNLIDSLLFVFGFRASKIRSAKVSNLIHKSAGRNPDKCTVTIHFQRIVDIPGHYEVVKDSEFTISRTAFQNNSSSYAIDGRPATKNEVEARLRRVDIDIEHNRFLILQGEVEQIAMMKPVKTTKSETGMVEYLEDIIGTNRLEPFVKLFQRRVNRLTCDLSQQRIARDHARNSKVAMENPVRAAIEFLMKENEATTIHMKLEQRRRQRYLDKIAPKQAELDKMKEEMKSIAETLDTNKNEYKQSEEAQKVMIEERSKLDKNFDSLSKELSDLGTEETRRKEALKRHQANISKAEAEKEKEVKKRSNLEAAPEKAERKIAKCQEEVEQLLEIEKTANEEADKNLDEFEKRSEAPKEEQKKIQETWAQKSNEFNKVRGEARIAREDFEDLKKLANSGTDKLIELKKRLESSEESYAKEKDELDKLKPEFDSWNDKLKQLSTELPTLRNTARQKNQDLAKTRDRLETLRQQNSSCSSSNKVIQALMKEKEAGRIKSFHGRLGDLGVIDPKYEGAICTNFGARLNYLIVGKEEDAKNVINFLVANKLPRQTVQPLDKIKCDKRDLAPNPTNPLPAPRLIDLIDCDPVLKPAFYDMVRSAIVGDSTQEAQRMHRMPACRGVTVCTLEGSMIHPSGSFTGGGKTVKGLILTDKNKMAKQVTPEDKAAERDLAEKLGKLRDEADELKGQEHEMDGQLIEARRKVAEMSNRLSIVTSSVQSAAPAIETLKKTIANQEKEAAKVKVDAKTLEDKQKIVEELEKKRDELGEEAAKVKARQAEIQSKLDGIFKELVQCHRDEAKESLQKRQKLEKDIAKETANISNSGRNIAKCDENISRHDKDIEKMKKKCEELMEKAIDDEEVKSKKETVERFEKQIKKLQTKGEEMTKKQSELSAAETKLEGELKKCSEGIKELKESMLADRLKVEDIEKKLAALKVNRIPRFQFLIESSRPEDLEMQIDDKMPVVDENQSPEEVERQKKHMACVMSDAAYALEFEMRQKVLENTESYENVDGEDRVPVELLSDEKINEISSRDAEEMQMKLKVCEQQVEALKAKVDISSIKAYVDKVKQYNEQVIKLTIATEVHRKHNQELQRIKQMRLEEFHSAFEFIGKHLVAVFKMLTDGGDAKLEYIDKDDPFRQGISFMVRPAKKAWKQIQFLSGGEKTLSSLALIFALHMFRPTPFYVMDEIDAALDYRNVSIIAQYVRQKTENAQFIIISLRNNMFELANRLVGIYKVDGCTRNVAIDPLRVCEMAKQITDSLGQATCTLPDEVTQRFNETMSRQNKEMIAQEKQYPNFPSSNEISKAEKIVNVEGRVRKELIQTTRDVTSRPQSKATTSGDGTERPASRSASRPESRINQMKYPAPRLVERSSSQNVRSPRKARNIEADETTPPSKRSNSASTPKRSPMKPLTPSSKKKEKAIVDDDDDME
The following text describes a protein:
Function:
Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).
Subcellular Localization:
Nucleus.
Sequence:
MGMATAAAATTAAPDKLRQPCRPRPAAPISSSKNRVPKAPVVIAHECPSAMRAHVLEVPAGRDVLSSVAAFARRGRCGALVLGAAGHVADVVLREPALVLRGTTEILSLAGCFFPSPAASAAGVAVFLAGPRGSVLGGAVAEGGLVAAGPVVVMVATFVAAAIDRLPLVKGDESSKADGSDVHGVAEQWRCGGKPVQQQCGWAPLCRKLGAKS
The following text describes a protein:
Function:
Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular locations. May be required for the initiation of neural tube closure.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, myofibril, sarcomere, Z line. Cell projection, ruffle. Cell projection, podosome. Cell projection, lamellipodium. Cell projection, axon. Cell projection, growth cone. Note=Localizes to stress fibers and Z lines. Preferentially expressed in the excitatory presynaptic terminals (By similarity).
Sequence:
MSETSSHDSFYDSLSDVQEEGKSADFFPGLSAFLSQEEINKSLDLARRAIDSSETEDFDSEKEISQIFSKSPISLCETPSHEEPKSGKQTSSERPQDSRRAPVQPLTGDQAERITSPGSKRKPGVSPLLASPSYIRSLRKAEKRGAKNPNPSSKPKTAQQSKAGPQSQLCDKAASFIEELTSIFREAAKPRNRSPNGESSSPDSGYLSPKNQPSALMSASASQSPTADQLDQLEMDAEVKQAQGSLCYQAHQASEETLPLAHIPHPQPQKARHLPTAPRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELYNSPDVQIHCESGELHTLVIAEAFEDDTGRYTCLATNPSGSDSTSAEVFIEGASSTDSDSESLSFISKAGAMPQAQKKTTSVSLTIGSSAPKTGVTTAVIQPLSVPVQQAHSATSYLCRPDGTTMGCLLPVFTKELQNTAASEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAEPEEICTLVIAESFPEDAGIFTCSATNDYGSVTSTAQLVITSANNENCSYDSTGEPNSDHFQHFPPPPPILETGSYELASQKPSEIQQVNSPNLGFSMAALQMQFNTAERETNGVHPSHGVNGLINGKAYGNKSPPTPTALLSPTKEPPPLLAKPKLDPLKLQQLQNQVRLEQEACAWPPAPPGVPCNSSSSGSSAPPSPPFPPPPPAFPELAACASPVPSEPMSALASRATAMQSSGSFNYARPKQFIAAQNLGPASGLPTPTSSPSSSSLPSPLSPTPRPFGRAPGPPFVEPEAMWGPSSPSPPPPPPPVFSPSAAYPVPDVFPLPPPPPPLPSSTSHCASPARFGPSQTPAAFLSALLPSQPPPVAVNALGLPKGVTPAGFPKKSSRTARIASDEEIQGTKDAVIQDLERKLRFKEDLLNNGQPRLTYEERMARRLLGADSANVFNIQEPEETAANQDAGAPRASVGGPLDGQKEYKVSSCEQRLISEIEYRLERSPVDESGDEVQDPDVPVENATAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQGRVSCTGRLMVQAVNQRGRSPRSPSGHPHARRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPIRPDSAHKMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFNLELVVAAKEAHKAPVFMEKLQNTGVADGYPVRLECRVSGVPPPQIFWKKENESLTHSTERVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDVYTQWHQQPQTTKPKKVRPSASRYAALSDQGLDIKAAFQPEASPSHLTLNSGLVESEDL
The following text describes a protein:
Function:
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). In the absence of CLPP3, modified ClpPR core(s) could be formed, albeit at strongly reduced levels.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MEMSLRLASSSTSNPICLLNPGKNLNFPIRNHRIPKTSKPFCVRSSMSLSKPPRQTLSSNWDVSSFSIDSVAQSPSRLPSFEELDTTNMLLRQRIVFLGSQVDDMTADLVISQLLLLDAEDSERDITLFINSPGGSITAGMGIYDAMKQCKADVSTVCLGLAASMGAFLLASGSKGKRYCMPNSKVMIHQPLGTAGGKATEMSIRIREMMYHKIKLNKIFSRITGKPESEIESDTDRDNFLNPWEAKEYGLIDAVIDDGKPGLIAPIGDGTPPPKTKVWDLWKVEGTKKDNTNLPSERSMTQNGYAAIE
The following text describes a protein:
Function:
May participate in nuclear egress of viral particles. Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL76 supposedly acts on this process through its effect on host nucleoli (By similarity). Induces cell cycle arrest in host cells at the G2/M phase following by apoptosis. The mechanism involves the inhibition of host mitotic complex cyclinB/CDK1.
Subcellular Localization:
Virion. Host cytoplasm. Host nucleus, host nucleolus. Host Golgi apparatus.
Sequence:
MPSGCGDDADSTGNALRRLPHVRKRIGKRKHLDIYRRLLRVFPSFVALNRLLGGLFPPELQKYRRRLFIEVRLSRRIPDCVLVFLPPDSGSRGIVYCYVIEFKTTYSDADDQSVRWHATHSLQYAEGLRQLKGALVDFDFLRLPRGGGQVWSVVPSLVFFQQKADRPSFYRAFRSGRFDLCTDSVLDYLGRRQDESVAHLLAATRRRLLRAARGKRAALPRARASAVAGGRGGGNARRGLARGRAHGPGAQTVSASGAEGSGSQGTDLLRGSRRARVRGGGAVEPAVRARRRTVAADAATTTVSSAFVVPRDRRGRSFRRPTRSL
The following text describes a protein:
Function:
Redundantly with pde-5, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels.
Sequence:
MNRARKTSSCGCFRSAFCLLKPSTSSASEEHGDSDKKLLSVQLITPRDEEEQTSSRSIKIPPLDLNGLDCKKNAVAARRAGRRRTSEGGGVRGKGHFAEVVLDGLQRPVSLLRNQKEKSNSDDNCQEKEPTSPSSSRKKSYDNAPALESLEKLRYILHQLNSGQLPLEDLKRNIEYAALVLETAYMDETRRICDEDDDLAEVTPETVPDEVREWLAATFTRQNAGKKRDKPKFKSVANAIRTGIFFEKLFRKQQVVQCPIPPEIAELMKEVCTWSFSPFQLNEVSEGHALKYVGFELFNRYGFMDRFKVPLTALENYLSALEVGYSKHNNPYHNVVHAADVTQSSHFMLSQTGLANSLGDLELLAVLFGALIHDYEHTGHTNNFHIQSQSQFAMLYNDRSVLENHHVSSCFRLMKEDDKNILTHLTRDEYKELRNMVIEIVLATDMSTHFMQIKTMKSMLSLPEGIDKNKALCLIVHACDISHPAKPWNLHERWTEGVLEEFFRQGDLEASMGLPYSPLCDRHTVHVADSQIGFIDFIVEPTMVVCGELLVKMVEPLVSLPPTDSLFPPSVDGGDDKSPSNALSPLPDLRNSSTSPSSIRRIPLNYAGKLDIPTPWMKFLHENKAHWKERAAKEEEERKIKEAAEAEAAAKQVEENKENGVTTN
The following text describes a protein:
Function:
In concert with FKH1, plays a role in directionality of mating type switching by controlling which donor mating-type locus is inserted into MAT locus during mating type switching.
Miscellaneous:
MISCELLANEOUS: Present with 2120 molecules/cell in log phase SD medium.
Sequence:
MEENKLSGNKPIQLATWSNQMGSPENNGNNANNGSDVQNVIQKALGLIRQLNNNGLMSPMEEEHSQPSSSQETLSVDREINEQGRLRLLMQAKDDNTRKEVGTYSSPMDSAYARENMLNVLQSLVTHLNQAVSQIQQLKFKNMILTSNENNIQSRHEVEDNLQKQQFERMKCQFLLERQSLKDQLRKRENKIVKYKQKIIEKNKKLNNLAKVLNQHAISDTSQIDSFSSSVKKTPSSTTTPQEMKSDMLNTLGILATHVLKDEIDDDSGNQTILQLAAGSISNDCNTTELEITCSPEMGRTITHNRPNTKDESIQDSHGNRTLQLPKMKSFSTIDGSIKDIK