lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta.
Miscellaneous:
MISCELLANEOUS: Rtl1 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes; MISCELLANEOUS: Rtl1 is an imprinted gene located in a cluster of imprinted genes on distal chromosome 12. It is expressed from the paternal chromosome and has an antisense transcript expressed from the maternal chromosome containing 2 microRNAs, mir-136 and mir-127, with full complementarity to Rtl1; mir-136 and mir-127 are processed from an antisense transcript, Rtl1as, and may function as small interfering RNAs to silence Rtl1.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIEPSEDSFETMMELKNPSSKQMESSEGSSNTVEETPGSSGAQAGAQAGAQAEAQAETQVEAQAEAQAEAQVEAQVEAQAGSDSGPAQEEKEPPSGPLKEMQELPTNLLQEVEEPSSGPHQEMQELPTDLLQEVEEPSSGPHQEMQELPTDLLREVEEPSSGPYQEMQELPTDLLREVEEPSSGPYQEMQELPTDLLREVEEPSSGPYQEMQELPTDLLREVEEPSSGPYQEMQELPTDLLREVEEPSSDPCEASSNDLPQDMEESSDDGSNQESSDGSNHELSNGSNHESSFGSNPESSDVSNLESSGGSNQESSDGSQKESSYDSNPELSDNSNQELSDNSNQESSDSSNQSSDISNQEGSEPLSEASDYSMDETINSSETQSDQDDTDLGDDEEEEEEEGGEEEGQPKNSPEEVVATMGNVISLFLRMQDLKEQQRVAERLMMQAINEGRLPSLRPFSGDRRDYHEFVVLCQMTMQNYPSMLYNDELRVKFVIRHLTDLALEWANDLVEQNSPVINNFSAFLEAMSEKFEYRQTLRVAEDAMFNIRQGNRCAADYINEFRGLIPTLGWPDEVLQAHLCQGLNEEIRHYLFRIPQPNSLDNLIVLVLQLEEKLAERRALLRLPPESRPRSVAWMDAPAPEKWRVSSWLPNEFHPDIDRDHLFLLLLVRVDPYHSVAVRALVDSGAEGNYMDERFAQEHYVELYEKPYPQIIQGVDGIPIGNEPVWLCTEPLVCVHQKHYEYIEFDILPSPNFSIVLGMKWLRTHAPEVDWMRGRCTFHSPYCLRNCFTPPPPCIALETYSISLLPGLPHTYSDLADVFNPREADDETSDQPSSDGSDDLSESEPSELQQAGDSDQSGVFYESGARETLEPVSARMQEKARQQEKAREQEEYWILYDMLTDRQDYTQMVPELFDQLHGAAWFTKLELLGIKESEMRHTVTHTEDTWRASFGFGLHQMRCYRPFTMNSYSDEGNNIVHFILKDILGLFVICHGREVLVYSMSQEEHSQHVRQVLVRFRYHNIYCSLDKTQFHRQTAEILGFNISPKGVKLNKNLMNLIVGCPVPGSRRCLQSVIDLVYPYRHFVENFAVIAAPLVRQLLSSEPYYWGEEEQEALESLKRAFRKSPVLYHPKPQNPFYLETDITGSFLSASLVQTDDETGKKSTCAFYSRPLSTMEVEYPRVEMRILPIRAAFMVWCRYLENTEEPIMILLNTEDLASLNNDRLTVLLPGHWVFFFSHFNFGVMEMPAEGDTQALFRRCWNQRGFRARFLRPLLLMSIRANLRYFDRSSETEDKEDDEEEEEEDGEEEEGEEEEDGEEEEGEEEEDGEEEEEEEEDDEEEEGEEEEDGEEEEGEEEEDGEEEEGEEEEDGEEEEGEEEGEEEEEGEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEDEEEEDEEEEDEEVPSMVRELLAAIPMDHILNGLLAHFSVAQIRAVVLNFFRGLLYWKSLLGVAAVLVMLRARQPLSPVPAPNLEVARPQHRHTLRLILDSTLIASSGMATAIAQLLSQMPPLVGANTLPARELAELFLGPRCWHRNALHSQPPRGMRFTPGFWLTLCEFFGVRVNPEDDVFPDPYQHRYLELHVVGDEDVVLREALQDDLQRYRQCGLHDGLQDTSQDAQDNDVQEDLFGDQEAVTFRPRNLLDPEVLDFLNNRLLYTLGTDGRLTLLSRDQVAQALTRFLAMASRMALPSPAREQARLEELSDSDDELD
The following text describes a protein:
Function:
Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
SAMAEFYVKPGNQERGWNDPPQFSYGLQTQAVGSKRNLLNKRVPPPQLDASQASVPSGAPPPVVPSAPPLNPLAPPPCGVATRPLQCPAVSRAGPSDPAAGENEPDVDDVMAQLSWALSACKHTVKKQVCDDVGRRLKLFEEMWRNGKLSLSVKRRMNLLIQEMKRQNWDLADEMHRSLMVDHVNEVSQWMVGVKRLIAEMRNLPLEALNNESQEQSSEVQTNVKTSLD
The following text describes a protein:
Function:
Required for protection of the roots from inhibitory compounds. When expressed in a heterologous system, confers resistance to tetramethylammonium chloride.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MADPATSSPLLDDHVGGEDERGRRSRSSTLVQKVIDVEEAKAQMIYSLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANSWATVSGFAFMVGLSGSLETLCGQGFGAKRYRMLGVHLQSSCIVSLVFSILITIFWFFTESIFGLLRQDPSISKQAALYMKYQAPGLLAYGFLQNILRFCQTQSIIAPLVIFSFVPLVINIATAYVLVYVAGLGFIGAPIATSISLWIAFLSLGTYVMCSEKFKETWTGFSLESFRYIVINLTLSLPSAAMVCLEYWAFEILVFLAGVMPNPEINTSLVAICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVKLSLVLALGVVIVLLVGHDGWVGLFSDSYVIKEEFASLRFFLAASITLDSIQGVLSGVARGCGWQRLVTVINLATFYLIGMPIAAFCGFKLKFYAKGLWIGLICGIFCQSSSLLLMTIFRKWTKLNVATV
The following text describes a protein:
Function:
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
Sequence:
MMKLRHKNKKPGEGSKGHKKISWPYPQPAKQNGKKATSKVPSAPHFVHPNDHANREAELKKKWVEEMREKQQAAREQERQKRRTIESYCQDVLRRQEEFEHKEEVLQELNMFPQLDDEATRKAYYKEFRKVVEYSDVILEVLDARDPLGCRCFQMEEAVLRAQGNKKLVLVLNKIDLVPKEVVEKWLDYLRNELPTVAFKASTQHQVKNLNRCSVPVDQASESLLKSKACFGAENLMRVLGNYCRLGEVRTHIRVGVVGLPNVGKSSLINSLKRSRACSVGAVPGITKFMQEVYLDKFIRLLDAPGIVPGPNSEVGTILRNCVHVQKLADPVTPVETILQRCNLEEISNYYGVSGFQTTEHFLTAVAHRLGKKKKGGLYSQEQAAKAVLADWVSGKISFYIPPPATHTLPTHLSAEIVKEMTEVFDIEDTEQANEDTMECLATGESDELLGDTDPLEMEIKLLHSPMTKIADAIENKTTVYKIGDLTGYCTNPNRHQMGWAKRNVDHRPKSNSMVDVCSVDRRSVLQRIMETDPLQQGQALASALKNKKKMQKRADKIASKLSDSMMSALDLSGNADDGVGD
The following text describes a protein:
Function:
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Man(9)GlcNAc(2)-PP-Dol to produce Glc(1)Man(9)GlcNAc(2)-PP-Dol. Glc(1)Man(9)GlcNAc(2)-PP-Dol is a substrate for ALG8, the following enzyme in the biosynthetic pathway.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEKWYLMTAVVLLGLTVRWTVSLNSYSGAGKPPMFGDYEAQRHWQEITFNLPIKQWYFNSSDNNLQYWGLDYPPLTAYHSLLCAYVAQFINPDWIALHSSRGYESQAHKLFMRATVLIADLLIYIPAVVLHCCCLKEISTKKKIANALCILLYPGLILIDYGHFHLGLALWGVLGVSCDWDLLGSLAFCLAVNYKQMELYHSLPFFCFLLGKCFKKGLKGKGFVLFVKLAGTVVASFTLCWLPFFTERAQALQVLRRLFPVDRGLFEDKVANIWCSVSVFLKIKDILPHHVQIIVSFCLTLLSLLPACVKLTLQPSPKGFRFTLVSCALSFFLFSFQVHEKSILLVSLPVCLVLSEIPFMSTWFLLVSTFSMLPLLLKDDLLMPSVVTTMAFFIACATSFSIFEKTSEEELRLKSFSVSVRKHLPRFTFLPRIIQHLFIISVITMVLLTLMTVTLDPPQKLPDLFSVLISTELTSANPPLLLRKTGPELTSVPIFLYFICGTPTTAWCAKRCHVRTQDSNWQTPGRQSRTYT
The following text describes a protein:
Function:
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
Miscellaneous:
MISCELLANEOUS: The enzyme is also highly resistant to organic solvents such as ethanol, methanol, N,N-dimethylformamide, and Me(2)SO at 50 degrees Celsius. Loss of activity is not observed in the presence of these reagents even at a concentration as high as 40%.
Subcellular Localization:
Cytoplasm.
Sequence:
MPSARDILQQGLDRLGSPEDLASRIDSTLLSPRATEEDVRNLVREASDYGFRCAVLTPVYTVKISGLAEKLGVKLCSVIGFPLGQAPLEVKLVEAQTVLEAGATELDVVPHLSLGPEAVYREVSGIVKLAKSYGAVVKVILEAPLWDDKTLSLLVDSSRRAGADIVKTSTGVYTKGGDPVTVFRLASLAKPLGMGVKASGGIRSGIDAVLAVGAGADIIGTSSAVKVLESFKSLV
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSLKALDTVFKIGKYILLTPETPTTKKPSLKKRFYALLLIIIYTITSSFCMFLQSAVFRHRSLMQNSLRVVVSMNSYFSAIFSLIRINSTTRSWYYMVKNLSQVSSSGTNCKCTFMAWFTVVLITRLYDTFVFMKMFGFRFLIYSVSDLVLFFRLIFSIITAITVLQMIQQCYHFQKKTLLTRIANSVDSDQVFETLAKLQPDFFCLQKAVSHFNDIFGWDILFYEFFVVCRTLVYIDDTVKMPEHLRKRQHIDVVLEISLKIVLMAFFWLLILHFTLVCDQVLKKYEEILNILLKIKFFLRKKVNKRRSRCLRRIEQSCPEFSAARFYCINRATLFSLLNAATTFLIVLLQFKVY
The following text describes a protein:
Function:
Non-catalytic component of the proteasome.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASGASVIAIKYNGGVLMAADTLLSYGSLAKWPNIPRIKLLGSHSAVCATGSYADFQMMAKQVEDNIERQRMYYNVDELNPSEVFSYLHRSIYQKRCDFEPCLCQMVFIGVRDSETFLAAVDDVGTRWEDDCVATGYGAYIALPLLRQALEKNPGGLSRAQAVQILTDCLRVLFYRECRTINKFQMADAAGDGVRISEPFDVETNWEYEGFCFEKTAIIR
The following text describes a protein:
Function:
Putative aminopeptidase.
Sequence:
MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTTDRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQRVTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDMIVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGLRGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLRDAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRDDYENAVKLITEVIKKLDRKTVDEITYQ
The following text describes a protein:
Function:
Does not show antimicrobial, myotoxic, hemolytic and cell-promoting activities.
Subcellular Localization:
Secreted.
Sequence:
MRLAYLLLLLVAVLFQAGGGSAKPIMFFEMQACWSHSGVCRDKSERNCKPMAWTYCENRNQKCCEY
The following text describes a protein:
Function:
Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
Subcellular Localization:
Mitochondrion.
Sequence:
MLQNGRKIIPEGLKYAKYTPTNFKLKRALVVTKLSRYEFEQLRHPELSPDQLQQKLRDRGTDVEMVLHLHKVHKDFERRVVQSFQDVGCEVKLSSRLEFRSSLSKDVMSWADVIVPVGGDGTFLLSAGRASPLFALSQQKTPIVGFNSDPLHSEGRLMLPKHYSDNPADAVSRIKSGDFKWMHRSRVRTTMLGSNGNIPEPTDLFRHTEVKMEQVSTAPEMLDQDMAYKYKAKMKRVLPYLALNEVFIGEHLSARVSHLQLVLDHQDVVNKTKCSGLCVSTGTGSTSWHTSINRITSRDVDDLLRSLPDGDSKNVMMLRQNAEEIAQRYNQGLLFAPDDPRLCYSIREQICVGVWPSPKTFKERDFVQTVFVKSHCIDANLVIDGSISFPFNDGAKALLEVHPEDALLTIALD
The following text describes a protein:
Function:
Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cell membrane. Cytoplasmic vesicle. Note=Largely located to vesicle-like structures.
Sequence:
MPGTVATLRFQLLPPEPDDAFWGAPCEQPLERRYQALPALVCIMCCLFGVVYCFFGYRCFKAVLFLTGLLFGSVVIFLLCYRERVLETQLSAGASAGIALGIGLLCGLVAMLVRSVGLFLVGLLLGLLLAAAALLGSAPYYQPGSVWGPLGLLLGGGLLCALLTLRWPRPLTTLATAVTGAALIATAADYFAELLLLGRYVVERLRAAPVPPLCWRSWALLALWPLLSLMGVLVQWRVTAEGDSHTEVVISRQRRRVQLMRIRQQEDRKEKRRKKRPPRAPLRGPRAPPRPGPPDPAYRRRPVPIKRFNGDVLSPSYIQSFRDRQTGSSLSSFMASPTDADYEYGSRGPLTACSGPPVRV
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDLPVEEWKSYILEKWALLPKSVQVTISKAETLSDIFLHSSSLLQPEDEMFLKRLSRGYLVGKDPNAPLFYREEGNKKFQEKDYTGATVLYSKGVSHSRPNTEDTSLCYANRSAALFHLGQYETCLEDIVRAQMHGYPERLQPKMMLRKAECLVLLGRLQEASQTISDLESSFAAKPTLAASQFQILQRTLCRLKMKIQKKENLTETVSAALTKAFEDMDLREENKQISSASASVSLCTDPFKGRYLIATKDILPGELLVKEDAFVSVLNPAEVLPLHLGLESKWDTRVTNGDLYCHRCLKRSLAPVPCDGCSYAKYCSQECMQQAWDLYHNIECSLGALLLTLGVFCHVALRSTLLARFEDAGEVTRKLCGDISNKDTRLPESKNLVQTLSYDLGGESEKNGKTVETPIPGCDINGKYENNYYAVCNLLPHTENHSAEYKFLCALSISALCRQLEAASPQALMTGLTSSKLKAAMAPVLCPESSIWGVAMLRHMLQLQCNAQAITAIQQTGSKENIITDSRQVRLATGIFPVVSLLNHSCSPNTSMSFVSTVATVRASQHIGKGQEILHCYGPHESRMGVAERQQKLRSQYFFDCTCPACQHGKHRTTAEPRWEAFCCCSCRALIQGDEVLSCGNASCTESVSRDHLVSRLQDLQQQVGIARKLLRNGKLERAIQQLLGCQHDAESFLSAEHSVVGEIEDDLAQAYAALGDWQKSAAHLQKSLRVVEVRHGPSSVEMGHELFKLAQIFFNGNQVSLLELTSECGTPQLQAFHRE
The following text describes a protein:
Function:
Iron-sulfur subunit of the xanthine dehydrogenase complex.
Sequence:
MNHSETITIECTINGMPFQLHAAPGTPLSELLREQGLLSVKQGCCVGECGACTVLVDGTAIDSCLYLAAWAEGKEIRTLEGEAKGGKLSHVQQAYAKSGAVQCGFCTPGLIMATTAMLAKPREKPLTITEIRRGLAGNLCRCTGYQMIVNTVLDCEKTK
The following text describes a protein:
Function:
Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
Sequence:
MKRKTSEIWCFFRAVDDTFAVCNICKAKLSYKTTTTNLSKHMNRMHPTSGLNRNSKYKFQPQTTIAIDRNKAKPRNSTQELILLEFVKKHPRLLQNPTWETRGNLESLWEELSSELNSHGPPRKDIATWRRALKDWKRFILRKVEKNEMQNMPFGTSLTSSEETIATLCRLNEDVSQIIMKVSDDEMHENSTTEFDVDEVEDVVPEEDGGALQTSAEYVYEPEENKTDIDPLYLQSNKRAALASSRLAEEETTLLDKISNNLEMVHDTANSVQLALNEFFVLYKQKLYEDKRHHLAIEQLMAEKIELKKKLLEIEQKKLSLK
The following text describes a protein:
Function:
Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine.
Subcellular Localization:
Nucleus.
Sequence:
MCAEVGPALCRDMERNSLGCSEAPKKLGLSFSIEAILKRPARRNDVDRPEGPGGEGPGEAVASGSRLEKPPQDQPQEGRKSKRRVRTTFTTEQLHELEKIFHFTHYPDVHIRSQLAARINLPEARVQIWFQNQRAKWRKQEKIGSLGAPQQLSEASVALPTNLDVAGPMWTSTALHRLAPPTSCCPSAQDQLASAWFPAWITLLPGYPWDTQPVPSPPIHQTCIPVLCILPPPHPKWGSICATST
The following text describes a protein:
Function:
May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen. Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum (By similarity).
Miscellaneous:
MISCELLANEOUS: There are two genes coding for HUT1 in strain JEC21, due to a translocation and segmental duplication on chromosomes 8 and 12.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGVLRLAVCISGVYAAFLLWAIAQERLSKPFPSVHPHPHQQPHSPSDPPPGDKFPSPLFLNFAQALASSLSALCYLSFKAWRDGWKGRGLGQLLGLKEVFGKSQTALNGDAKANKKESELNEKTKEVVEKAPKPPKKSLLALLVQVSVFQTIASPIGFLALRHISYPTMVLGKSCKLIPVLLLNVLLYRRKFSPHKYIVVALVTVGISMFMLFAETSKKKKGGSDSMWGLVLLLVNLLIDGLTNSTQDQIFSSYPSYTGQQMMFTMALTTQIILLPLLVLPLPTNPISLLAHLPPPFGSSVPTSTLSFSPPAALESISFLLSHPSALAPLFAYALLGGLGQLFIFETIQHFGSLTLVMVTVTRKLFTMLLSVVVFEHRLTKGQWLGVGVVFAGIGVEAGMKRKDVMKKAKKD
The following text describes a protein:
Function:
Nucleolar protein that is involved in ribosomal RNA (rRNA) processing. Also plays a role in primary cilia resorption, and cell cycle progression in neurogenesis and neocortex development. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, nucleolus.
Sequence:
SGHPLPGRAHWGPRFPGVTPRCPHCLAGRTGAVCPLPQGSPSASRPPLLFPGRPLSPRRAGPLSGFLIGSAASPPAPAGSLHLPEFGACWALFLGVPQAALPSPLHRCPHSAIPVKFSGKQQASHYLYVREHRVREGTKSSWPQKRTLFVLNVPPYCTEECLSRLLSPCGPVRSVELQEKPDLAESPKEPQSKFFQPKPIPGFQVAYVVFQKPGGVSAALALKGPLLVSTESHPVKSGVHKWISDYRDSVLDPEALRAEVDTFMEAYDKKVAEEEAKAQEEEGVPDEEGWVKVTRRGRRPVLPRTEAASLRVLERERRKRARKELLNFYAWQHRETKMEHLAQLRKKFEEDKQRIELMRAQRKFRPY
The following text describes a protein:
Function:
Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization. Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MDGDRTPEEQIEIAESDQGPQLDDNVELANVFSYSLDQRIMEGCVISAILEPRGLETIVAVSVTNKIIIKDKETSLNITETIRCIAAAPFGDGYDCIIIGTDSSVICYDVHNNLTVFRNDVPDGVSCFVYGKLGELDEAIYCGGNCCIWGFDKTGANTYWTVTGDQVTTMCLSDYDNDGETELVIGSPDFEIRVFKNDLMRTELMETDEITCLAHVANGCFAYSLNNGTIGTYVLKERQWRIKSKSNVSKIFNFEEEGLMVVVWKQGKVDLRFAHNGEVLSRDSVSSHVASASVSKKGDESFITVVCLDGKVKGFKIQRAQNGSIDKTQQLIREFGQKKHNLMMELSNYEQEEQLADVEKDRDFRIPVDTEVAVVFVVNTELQLLSLRVEASHNIPIRGVLIFAEGLFEGESYIWIPPNEYQSRSVIDIPLVIDKDSTNDLHTKVFLGQVDSNKLMVMENTRILPKFCRFTLLREEYSKFFYMPTAYIQFDINSRAAKLSEWVQESFTIDASLVEMFDEPEGEFKFMGLRPKHEKSLMFKISHSEKTCKIYHDKIETMGAIVQSYASFYQIQNMESVAHFPDVFKEADEILEEIDPMTEVRDRLTAELQERQAAVKEIIIRAEDSIAIDNIPDARKFYIRLKANDAAARQAAQLRWNNQERCVKSLRRLNKIIENCSRLRVGEPGRQIVVSCRSAIADDNKQIITKILQYGASV
The following text describes a protein:
Function:
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MSPMFFATTFKEPDLLYIEDKEDIFHMVNVLRIREGEKIDVNYNSKIFRAYVEKIEEDRVICKIIEKIGNKEANVEVYLCQSLPKKESWEIILEKCTEIGVVGFIPLQTQRSIVNLSRDELNKKYQRWNKVIKEAVKQCGRNKLPLLYKVQTLEESLNLAKKENADILIAWEGAELSLKNIIRNNIRDKIFLFIGPEGSFTDEEINLMKKYNGIFFNMGPRILKVETAAIVASALLLYEKGGLGLF
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.
Subcellular Localization:
Cytoplasm.
Sequence:
MYLDERSNSLLKELLRHPDTSSTNLQAKFGLTRRQVDYSFQKINNWLEEQTYPKIHRAANGRFIVEPDLFQIIGEEDGEKTDWYIPSEKERASLIILMLTTGSEELSLNHFISELEVSKNTVLRDLKLVQKTLDKFNLEVKYSRMRGYLIDGDEWNQRTALIYAAEHIIESFGGEEYLQDFMQVDEARIKELREKLEQVEHHLNLHFIDNKMQILPYILEAVFRRMKKGQTITTSFLIDYNELSDTREYGAAEIFIEEEPNMPEAERMYITLQLLTSNVLPKQYLKSEETHKLRLALEQVLSEFEKKACIQLVDKESLLEKLFAHIKPAYYRIKYHLTTDYSILDKIDQEFQAVHYIVKESLAPLERFIGSKVPENESIFITLFIGGHLIESTEKLQTRLKAVVVCPNGLSISRLMEKTLRSLFPEIFFYQAMSIREFEQTKLGYDIVFSAVPLSTDKKFFLINQLMDGKERLELRRRVMRSVYLVDEVNISVDQLMKTISKFADIKDAARLEKVLADYLMPVPEENTSKHEGKSSLADLLEVTRITRKKSVKDWHEAIYHAALPLLSAGVVEPAYVEEMKRQYPAPIMNIILRNTIAIPHAETEKGVNSLGMSLLYLEEGLPLEGGKELHFIVVIAAIDKNAHFTALLQLMELSENKKELKKLADAANTEEMHQIIKNFTDLETKKTM
The following text describes a protein:
Function:
Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MPDQDPGAISPLQQTVASGTGAVVTSLFMTPLDVVKVRLQSQRPLTASEPMPPSRLWSLPYAKSPSSPIHREVPPILQWCSGTPVLVSKWCPLCHLVSGPYPLHGHHGRFCEDREARGTRTLWSGLPATLVMTVPATDDQPRTFLCGRALTSDLYAPMVAAALARSLYWFNYELVKSWLSGLRPKGKRPDIRGHELCGWRHLRDGGDHPDSTLRRGEDSMPGRAGGGGGCERLSPKDHQGRPFLCHHDQHV
The following text describes a protein:
Function:
Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis. Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD. Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDTKYKEDLFRKYVQYHEAKLDASDNKQRTVSDEYLRTAASAFLSLPKVDPLYRFRLIKFYEVCENSLKSLVTSNLRSLHNAAAMLETIGINLFLYPWKKEYKSIKTYTGPFVYFVRAALTDDDIRHILHNMGYIQELGTVYRLKDHVDTTQVKRVAFELFLARVECELLLEIYLQVKDRGYLEVDVVNERRSSNEDVRGCTDEMKRRAECKETSIARILLQKSASERAPSKDYFKPKVTKPSKSVDTYDNYWDSKNKPPLMPSLSLRKEPILVDADDDLKDEIIRPSPSLLTMSSSPHGCSDEFLNLSSNPNGVLRTNQTYGYYPSEDEVDLYTDPDTRMLNIKRQDFAKPDVWLLKNEMNPLYHKRSHLAKETAFMKCQSCGVSCGGPVCQKCDNVLIFRPDVPSHKQSSLSIKTTGQNDSYSSGPVLREKSSYGLSSQERASQQNPKMKPSSTLRCGFCNRQGASNTCTVCSKVSCNNCITAYCREYCCRKSDFHKFAPNNQLNYKSSQLPHLVLR
The following text describes a protein:
Function:
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG). May play a role in redox homeostasis. Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (By similarity). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in absence of stress; translocates to the nucleus in response to stress.
Domain:
The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large protein interaction surface on its interior side.
Sequence:
MSLDIQCEQLSDARWTELLPLIQQYQVVRLDDCGLTEVRCKDIRSAIQANPALTELSLRTNELGDAGVGLVLQGLQNPTCKIQKLSLQNCSLTEAGCGVLPDVLRSLSTLRELHLNDNPLGDEGLKLLCEGLRDPQCRLEKLQLEYCNLTATSCEPLASVLRVKPDFKELVLSNNDFHEAGIHTLCQGLKDSACQLESLKLENCGITSANCKDLCDVVASKASLQELDLGSNKLGNTGIAALCSGLLLPSCRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEGAQLLCESLLEPGCQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVELCKALGYPDTVLRVLWLGDCDVTDSGCSSLATVLLANRSLRELDLSNNCMGDNGVLQLLESLKQPSCILQQLVLYDIYWTDEVEDQLRALEEERPSLRIIS
The following text describes a protein:
Function:
Phosphorylates threonine at 'Thr-1823', 'Thr-1833' and 'Thr-2029' in the C-terminal tail region of myosin II heavy chain (mhcA) (By similarity). This phosphorylation is critical in actin-activated ATPase activity of the myosin and regulating the assembly and disassembly of myosin II filament. In vitro, catalytic domain phosphorylates mhcA, myelin basic protein, myosin regulatory light chain, casein and caldesmon. Drives the disassembly of myosin II filaments for efficient cytokinesis and recycling of myosin II that occurs during late cytokinesis. Can be activated in vitro by autophosphorylation.
Subcellular Localization:
Cytoplasm, cell cortex. Membrane. Cleavage furrow. Note=Localizes to the cortex of interphase cells, cleavage furrow of mitotic cells (at the late stage of cytokinesis), and posterior side of both migrating cells and daughter cells beginning to separate at the very late stage of cytokinesis. Localization is myosin II-dependent. Occasionally displays transient enrichment in pseudopodial extensions as well.
Sequence:
MEEKKTGAAAALALLNQKFPVADVIAGTKCERAIKWELTIGDDLKPKWTHSIVCVSIEKTPFAKGSCRTAHKLKDWSQPDQGLVGKFSTNKKTTRDSYFTDVLMQTFCAKWAEKFNEAKPPKPITFLPSYVYELIDHPPPYPVCGGEPFIEGDYKKHNNNSGYVSSDARNTPQSFSHFSYELSNHELLIVDIQGVNDFYTDPQIHTKSGEGFGEGNLGETGFHKFLQTHKCNPVCDFLKLKPINQSKKALLRGTLPVVQLMDFHDAIGLNGNGSGPKNNYDMNYFRNGGGAQQPISLDDEEKMLQEQLERIRAQQQQKSKPSPPLVKQPSGNNLHKQQSPSSPTSKPVPQIVKTPSQSNVVNKSPVSPPKENSNVKLEQDNINNNNSSISSNNDNSNNNNNNNDNINNSSNSSSVNSNSSSVSSSSSSSSSSSSSSTTNAAPISIQVSRNSPPPQQPIQPSSAAASASSTSSSNVPTPESTSTSSMEQTPDRSEFEKWDLTSIKNIDTVRGLQSECITGDSLRLYSGSNDGQIGVWDAVELKHVTNIKAHGKSIRAVIKRPGFDQNILTAGADSLVKEWDINTQQTIKEIKESNEVNTIFIQDNLLYTGCNDKTVKVWDMRSYECVKTLSGHTRAIKSVCAMGNLLFSGSNDQQIYVWNLATGTILTNFQGHEGWVKTLYAHNNMLYSGSHDETIRIWDLKTTRCVNTIKCKDRVETLHVTNQGIFAGSGDWLQVFSHDKYENLASLNTRSSILCLWRNQNQLFTGSLASNLKVWSWDKM