lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. Required for normal embryonic development (By similarity). May play a role in the nonsense-mediated decay pathway of mRNAs containing premature stop codons (By similarity).
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum. Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MAAPESGPALSPGTAEGEEETILYDLLVNTEWPPETEVQPRGNQKHGASFIITKAIRDRLLFLRQYIWYSPAPFLLPDGLVRLVNKQINWHLVLASNGKLLAAVQDQCVEIRSAKDDFTSIIGKCQVPKDPKPQWRRVAWSYDCTLLAYAESTGTVRVFDLMGSELFVISPASSFIGDLSYAIAGLIFLEYKASAQWSAELLVINYRGELRSYLVSVGTNQSYQESHCFSFSSHYPHGINTAIYHPGHRLLLVGGCETAEVGMSKASSCGLSAWRVLSGSPYYKQVTNGGDGVTAVPKTLGLLRMLSVKFYSRQGQEQDGIFKMSLSPDGMLLAAIHFSGKLSIWAIPSLKQQGEWGQNEQPGYDDLNPDWRLSTEKRKKIKDKESFYPLIDVNWWADSAVTLARCSGALTVSSVKTLKNLLGKSCEWFEPSPQVTATHDGGFLSLECEIKLAPKRSRLETRAGEEDEGEEDSDSDYEISAKARYFGYIKQGLYLVTEMERFAPPRKRPRTITKNYRLVSLRSTTPEELYQRKIESEEYEEALSLAHTYGLDTDLVYQRQWRKSAVNVASIQNYLSKIKKRSWVLHECLERVPENVDAAKELLQYGLKGTDLEALLAIGKGADDGRFTLPGEIDIDSISYEELSPPDEEPAKNKKEKELKKRQELLKLVNFSKLTLEQKELCRCRRKLLTYLDRLATYEEILGVPHASEQRYDAEFFKKFRNQNIVLSARTYAQESNVQALEILFTYHGSDLLPHRLAILSNFPETTSPHEYSVLLPEACFNGDSLMIIPWHEHKHRAKDWCEELACRMVVEPNLQDESEFLYAAQPELLRFRMTQLTVEKVMDWYQTRAEEIEHYARQVDCALSLIRLGMERNIPGLLVLCDNLVTLETLVYEARCDVTLTLKELQQMKDIEKLRLLMNSCSEDKYVTSAYQWMVPFLHRCEKQSPGVANELLKEYLVTLAKGDLKFPLKIFQHSKPDLQQKIIPDQDQLMAIALECIYTCERNDQLCLCYDLLECLPERGYGDKTEATTKLHDMVDQLEQILSVSELLEKHGLEKPISFVKNTQSSSEEARKLMVRLTRHTGRKQPPVSESHWRTLLQDMLTMQQNVYTCLDSDACYEIFTESLLCSSRLENIHLAGQMMHCSACSENPPAGIAHKGKPHYRVSYEKSIDLVLAASREYFNSSTNLTDSCMDLARCCLQLITDRPPAIQEELDLIQAVGCLEEFGVKILPLQVRLCPDRISLIKECISQSPTCYKQSTKLLGLAELLRVAGENPEERRGQVLILLVEQALRFHDYKAASMHCQELMATGYPKSWDVCSQLGQSEGYQDLATRQELMAFALTHCPPSSIELLLAASSSLQTEILYQRVNFQIHHEGGENISASPLTSKAVQEDEVGVPGSNSADLLRWTTATTMKVLSNTTTTTKAVLQAVSDGQWWKKSLTYLRPLQGQKCGGAYQIGTTANEDLEKQGCHPFYESVISNPFVAESEGTYDTYQHVPVESFAEVLLRTGKLAEAKNKGEVFPTTEVLLQLASEALPNDMTLALAYLLALPQVLDANRCFEKQSPSALSLQLAAYYYSLQIYARLAPCFRDKCHPLYRADPKELIKMVTRHVTRHEHEAWPEDLISLTKQLHCYNERLLDFTQAQILQGLRKGVDVQRFTADDQYKRETILGLAETLEESVYSIAISLAQRYSVSRWEVFMTHLEFLFTDSGLSTLEIENRAQDLHLFETLKTDPEAFHQHMVKYIYPTIGGFDHERLQYYFTLLENCGCADLGNCAIKPETHIRLLKKFKVVASGLNYKKLTDENMSPLEALEPVLSSQNILSISKLVPKIPEKDGQMLSPSSLYTIWLQKLFWTGDPHLIKQVPGSSPEWLHAYDVCMKYFDRLHPGDLITVVDAVTFSPKAVTKLSVEARKEMTRKAIKTVKHFIEKPRKRNSEDEAQEAKDSKVTYADTLNHLEKSLAHLETLSHSFILSLKNSEQETLQKYSHLYDLSRSEKEKLHDEAVAICLDGQPLAMIQQLLEVAVGPLDISPKDIVQSAIMKIISALSGGSADLGGPRDPLKVLEGVVAAVHASVDKGEELVSPEDLLEWLRPFCADDAWPVRPRIHVLQILGQSFHLTEEDSKLLVFFRTEAILKASWPQRQVDIADIENEENRYCLFMELLESSHHEAEFQHLVLLLQAWPPMKSEYVITNNPWVRLATVMLTRCTMENKEGLGNEVLKMCRSLYNTKQMLPAEGVKELCLLLLNQSLLLPSLKLLLESRDEHLHEMALEQITAVTTVNDSNCDQELLSLLLDAKLLVKCVSTPFYPRIVDHLLASLQQGRWDAEELGRHLREAGHEAEAGSLLLAVRGTHQAFRTFSTALRAAQHWV
The following text describes a protein:
Function:
Uptake of sulfate into the cell.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MASTSTAGDRIKKFLGIPADERLNDTACYVDGSFVESEPTTQDFLNEIRPTVQGTLNYLRELFPFVNWIFHYNLTWLLGDFIAGVTVGFVVVPQGMAYAKLANLAPEYGLYTSFVGFVLYWAFATSKDITIGAVAVMSTIVGNIIANVQKDHPDFDAGDIARTLAFISGAMLLFLGLIRFGFIVEFIPIVAISAFMTGSAISIAAGQVSTLMGIPNINSREETYKVIINTLKGLPNTHLDAAMGLTALFGLYFIRWFCTQMGKRYPRQQRAWFFVSTLRMVFIIILYILVSWLVNRHVKDPKKAHFKILGHVPSGFQHKGAPRLDNEILSAISGDIPTTILVLLIEHIAISKSFGRVNNYIINPSQELVAIGFTNLLGPFLGGYPATGSFSRTAIKAKAGVRTPLAGIFTAVLVLLALYALTSVFFYIPNSALAAMIIHAVGDLITPPREVYKFWLTSPLEVVIFFAGVFVSIFTSIENGIYVTVAASGAVLLWRIAKSPGKFLGQTEIYTAPRELVRGSKDSGLTQSLLQKSEHHTAFLSLDRDDLSNPELQISTPWPGIFVYRFGEGLNYVNSAKHLDNLTIHVFKHTRRTELNKFEKLGDRPWNDPGPRRGQAFLTDELVSRPTLRAIILDFSAVNCIDVTAAQALQDLRNQFDRYAHPDKVEWHFAGVSNRWTKRALVASGFGVDSLRTAKVQRENHKGGVQEVDQGPLVAIGPSVSASDIEAVPVGTSGSGSTDEKRPEGEGGATNGGMEKGSANGEDISTVPTATSADACALARDAGGKRLVPVFGINRPFFHIDVATALKSAVRNTGVVAAE
The following text describes a protein:
Function:
Tyrosine kinase involved in the regulation of tissues remodeling. It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQQGDE
The following text describes a protein:
Function:
mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for addition of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly.
Miscellaneous:
MISCELLANEOUS: Present with 3460 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MNYLEGVGSKKGGGGIASESQFNLQRRKEVESLLSKGENVPYTFQDEKDDQVRSNPYIYKNHSGKLVCKLCNTMHMSWSSVERHLGGKKHGLNVLRRGISIEKSSLGREGQTTHDFRQQQKIIEAKQSLKNNGTIPVCKIATVKNPKNGSVGLAIQVNYSSEVKENSVDSDDKAKVPPLIRIVSGLELSDTKQKGKKFLVIAYEPFENIAIELPPNEILFSENNDMDNNNDGVDELNKKCTFWDAISKLYYVQFFFKQAEQEQADV
The following text describes a protein:
Function:
[Mature tail spike protein]: Assembles together with p132 to form the three L-shaped long tail fibers and the collar structure at the junction between the tail tube and the conical tail tip. The three L-shaped long tail fibers recognize the host lipopolysaccharides that serve as adhesion receptor for virus entry. Each fiber consists of a thin proximal rod of about 30 nm connected by a hinge to a thicker distal part of about 47 nm.
Subcellular Localization:
Virion. Note=Component of the tail. Forms the L-shaped side fibers and are anchored onto the p132 dodecameric ring.
Sequence:
MAITKIILQQMVTMDQNSITASKYPKYTVVLSNSISSITAADVTSAIESSKASGPAAKQSEINAKQSELNAKDSENEAEISATSSQQSATQSASSATASANSAKAAKTSETNANNSKNAAKTSETNAASSASSASSFATAAENSARAAKTSETNAGNSAQAADASKTAAANSATAAKTSETNAKKSETAAKTSETNAKTSENKAKEYLDMASELVSPVTQYDWPVGTNNNSVYVKIAKLTDPGAVSCHLTLMITNGGNYGSSYGNIDFVEISARGLNDARGVTSENITKFLSVRRLGSPNLAWDNQLRYGLVEGDGYFEVWCYQRAFIKETRVAVLAQTGRTELYIPEGFVSQDTQPSGFIESLAARIYDQVNKPTKADLGLENAMLVGAFGLGGNGLSYSSVQSNVDLINKLKANGGQYWRAARESGANVDINDHGSGFYSHCGDTHAAINVQYNTGIVKVLATTDRNLASDIVYANTLYGTANKPSKSDVGLGNVTNDAQVKKAGDVMSGDLDIRKETPSIRLKSTQGNAHLWFMNNDGGERGVIWSPPNNGSLGEIHIRAKTSDGTSTGDFIVRHDGRIEAKDAKISYKISSRTAEFSNDDTNTAATNLRVSGKQHTPIMLVRDSDSNVSVGFKLNNMNAKLLGIDIDGDLAFGENPDHKQNSKIVTRKMMDAGFSVAGLMDFTNGFAGPWEAKNISDQELDLNSLMIKKSDPGSIRVYQCVSAGGGNNITNKPSGIGGNFILYVESIRKVGDTDFTNRQRLFGTDLNREFTRYCSNGTWSAWRESVVSGMNQDVSVKSMSVSGRLSGNELSVGGAGVLNGNLGVGGGATSKMPSSDKGIVIGRGSIVREGGEGRLILSSSGGTDRLLQLRPAGATSLDNQVEISCTSASAGDTKISFGQGAAIRCNNAGSPIISAKAGQMIYFRPNGDGISEGQMILSPNGDLVVKGGVNSKEIDVTASQSLPLKETTATTGIGVNFIGDSATECSFGIENTAGGSAVFHNYTRGASNSVTKNNQLLGGYGSRPWLGSTYTEHSNAALHFLGAGDTSATNHGGWIRLLVTPKGKTISDRVPAFRLSDNGDLWLVPDGAMHSDLGLVRSIETLNAAVPRFNAPSIQDGRGLKIVAPQAPEIDLIAPRGSGASAPAIRAMWCDGSLADTTRYIGATQPGSTFYIGASGHDGEKFDSMRGSVAIKSAGGWGPTSTPTQVVLETCESGSISRLPRWGVDHNGTLMPMADNRYNLGWGSGRVKQVYAVNGTINTSDARLKNDVRAMSDPETEAAKAIAKEIGFWTWKEQADMNDIREHCGLTVQRAIEIMESFGLDPFKYGFICYDKWDEHTVVSEYGPANEDGTENPIYKTIPAGDHYSFRLEELNLFIAKGFEARLSAIEDKLGM
The following text describes a protein:
Function:
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis.
Subcellular Localization:
Apical cell membrane; Peripheral membrane protein; Extracellular side. Lysosome. Secreted, extracellular space.
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGAFLGGPKPPQRVMFTEDLKLPESFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
The following text describes a protein:
Function:
Acts as a receptor for slt-1. Required for the guidance of the AVM pioneer axon to the ventral nerve cord. Acts as a unc-40 coreceptor to enhance the sensitivity of unc-40 to the madd-4 midline guidance cue to guide muscle arm extensions (muscle arms) and AVM mechanosensory axons towards the dorsoventral midline.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Domain:
The SUEL-type lectin domain, the transmembrane domain and the C-terminal region are required for the guidance of the muscle arm extensions to the midline neurons.
Sequence:
MNMHIVSPVLLLFWFGIIVTDGKLKSGFIGGSHHHEVNPIEGILRESLRSNRVQACDGERITLSCPRNTQISVQTGFYGRVVPENQLCPPQAGRKHSEANLDPLSMIHHSSTCDVIQAHTRISELCDKRRKCTVVVDSNTFEDDPCPTTSKYLQMAYGCIPMSFDEETFCTPKPTDPPRPEIRLECREGRRLAVYSAQMKTSPQCDPETEIRHECVSDVLPQVLRQCHAKEGCTLKSDGIKGHCRHGHLHVVYVCVNEEIFSEEAIKGELTSLETYLKEADAMQKQDDERFFKDVNDKTQWERVVDSEPAKDPDVHQIANDASYVTHDEYRMEKQDPPPITERVEPNLVGVGHDLLQVVQFFKENKEKAVMCIVLAVSMAAIVVLSACIITRLCSSNKDSSRSSRRSRSRRSLETSKLVSSNYGGSITPQHMMQDIEDEQFLRFSMGSAATSNPHYSHYDF
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MLRKCPLRRWRPEKRLPLRFRDVPEEFTDLRTADSRPVLFTAKRPAPLRDVTRLSDVLLDNTALSTHNPEDMAQKPVAVVAPERMGLPAQLVWYLEHRFLDTNRSLSTTATAATSSASSSTSFQGFTVAQARILQHMYATQDVAVCAPTGTGKTFALCLGVVARLMRDGPMKLLTTIILVSNDYLCWQVERWLQEMWWYPNDDRLVFAATSNLTEEHVYRRLTKEIVRDASQTRKIVGTIDNRPYVVVTTPDVLWRFYQRRRAAIQKREQRRNRKGYSFSLMPVLSTVDLIVVDEVDEVMPSTQPGAAGNLLLKELFRYTKYQAPVQVVLTSATLAGSTVNHIRRYMKKNLLADRTARVFEEARESATRLAAVSDTVSRAAVPHGIRHLFYTADTQREQRQCLAKVFAATCPSLHPLRSGEGEAGDGESSDPTSAAAAAHQDYILLILPDCAKVEDFISHVLLPGQADALRILGSQDDARCTDYLVERLDHTVQVQQQQRRRAETRKFIQRTVRKAEALDGDVGYPSSAPQPSPLFRRLEREVNATAAPIHAAASESQAPAPTSLATSPAVCAADSLTASSSPLRPPRRCFITCNCNNVRGLDLPHLTHVVILAQPTTALEYAHWCGRVGRFGRPGVSVTLMARSATRHMHQFCDSLGIAFRVEKRHAEVDVNAERWLSGADAE
The following text describes a protein:
Function:
Probable transcription factor that regulates lateral organ polarity. Plays a role in lateral root formation and development.
Subcellular Localization:
Nucleus.
Sequence:
MELFPSQPDLYLKISRRREEEQEKESQELQEQEVERRLGFQSKASDLDNKSSNNLIHTLQFTSNNEATKINSNQEHKESLDQDLRSIFMMRPIRGIPLYQNQVLDHYYYSSTSPNPFFFSEVNGQHASRRLITNPNCSFNLHNRHRRQAQPQPPRFTAKRGVRAPRMRWTTTLHAHFVHAVQLLGGHERATPKSVLELMDVQDLTLAHVKSHLQMYRTIKSTEKPTTSSGQSDCENGSQVNSEREARNLTGLWNNSSSEARFQLKAKASSGVDISSNENEWKNRRCPSNERLSSDSSSLTGTRPETETPNLDFTLATPNLSP
The following text describes a protein:
Function:
Regulates ARP2/3 complex-mediated actin assembly. Recruits ARP2/3 complex to sides of preexisting actin filaments, which may promote nucleation or stabilization of filament branches. Binds to actin filaments, but not actin monomers. Actin binding is required for ARP2/3 complex activation. May also have a role in linking the actin cytoskeleton to endocytosis. recruits components of the endocytotic machinery to cortical actin patches, known sites of endocytosis.
Miscellaneous:
MISCELLANEOUS: Present with 606 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, actin patch. Note=Cortical actin patches.
Sequence:
MALEPIDYTTHSREIDAEYLKIVRGSDPDTTWLIISPNAKKEYEPESTGSSFHDFLQLFDETKVQYGLARVSPPGSDVEKIIIIGWCPDSAPLKTRASFAANFAAVANNLFKGYHVQVTARDEDDLDENELLMKISNAAGARYSIQTSSKQQGKASTPPVKKSFTPSKSPAPVSKKEPVKTPSPAPAAKISSRVNDNNDDDDWNEPELKERDFDQAPLKPNQSSYKPIGKIDLQKVIAEEKAKEDPRLVQKPTAAGSKIDPSSDIANLKNESKLKRDSEFNSFLGTTKPPSMTESSLKNDDDKVIKGFRNEKSPAQLWAERKAKQNSGNAETKAEAPKPEVPEDEPEGEPDVKDLKSKFEGLAASEKEEEEMENKFAPPPKKSEPTIISPKPFSKPQEPVKAEEAEQPKTDYKKIGNPLPGMHIEADNEEEPEENDDDWDDDEDEAAQPPLPSRNVASGAPVQKEEPEQEEIAPSLPSRNSIPAPKQEEAPEQAPEEEIEEEAEEAAPQLPSRSSAAPPPPPRRATPEKKPKENPWATAEYDYDAAEDNELTFVENDKIINIEFVDDDWWLGELEKDGSKGLFPSNYVSLGN
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
Sequence:
MRSNRKEMIGKVVSAKMQKTIVVLVEQTYTHPLYKKTVTRRKKYKAHDEHQEAREGDIVLIRETRPLSKEKRWRLVRIIKRGEIAPTISEEENLENNETTVGVGDINDNASN
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MTDYLKDFIDRAADVPLQLRRRLALIRDLDEKAQALHREIDEHCKRTLAEKSQQHAAKKQKQAAGEDAGGSAAAPYDVESALKRLIGLGDEKVNIANQIYDFMDNHINQLDTDLQQLDGEIEADRKELGLEGDETACEKLGIEAPQGSRPHTVGKGAADQKKKRGRKKDESTAAAAGGLPPIENEPAYCICNKPSAGQMVGCDNPECTIEWFHFECVGLTEEPKGKWYCPVCRGDLQVKSGKKSGRR
The following text describes a protein:
Function:
Peptide hormone that functions as endogenous ligand for the G-protein-coupled apelin receptor (aplnra and/or aplnrb), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis. Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR. Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs (By similarity). On the other hand, APLNR activation induces beta-arrestin recruitment to the membrane leading to desensitization and internalization of the receptor (By similarity). Required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis. Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating the apelin receptor. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Positively regulates sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel sprouting. Involved in cardioprotective functions during heart failure. Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity).
Miscellaneous:
MISCELLANEOUS: Was named Toddler based on the phenotype.
Subcellular Localization:
Secreted. Secreted, extracellular space.
Sequence:
MRFFHPLYLLLLLLTVLVLISADKHGTKHDFLNLRRKYRRHNCPKKRCLPLHSRVPFP
The following text describes a protein:
Function:
RNA-binding protein with binding specificity for poly(C). May play an important role in neural development (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus.
Sequence:
MDDAGGLGGSGGFRPGVDSLDEPPNSRIFLVISKHTSELVLRERFSPFGDIQDIWVVRDKHTKESKGVAFVKFARSSQACRAMEEMHGQCLGPSDTKPIKVFIAQSRSSGSHRDVEDEELTRIFVMIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIENCDRSFRALLAEPKNKVSGSPEQDDYSSGRQEALGQEPRANLFPFVGEQQSEFSTFDKNDSRGQEAVSKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEVPRDPYSNYGHGVVQYFNVASAIYAKYKLHGFQYPPGNRIVVSFLDDGSNMTELIRKMATQMVAAQLASMVWSTTSQQQFLQYGGNAASQAPQIQTDVVLPSCKKKAPPETPVKERLFVVFNPHPLPLDVLEDIFCRFGNLIEVYLVSGKNVGYVKYADRKSANEAITTLHGKILNGVRLKVMLADSPREESKKRQRTY
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSKYGTIPAASSTPPAPPEGSCTVPDSTSRAERPGRRASAAFAALRPWRELTDPRALSVPAGRSDARRRARANLARFAANYKLTFLAVVSVSLLWQWRRWRSICLPALYLSVCLNYLSSKAFPLFLILALFQLVVTGSAASVLVALPVGLLLVGAHAVLHYCPAEDGTVDEEVGSIVWHRGIAPCDAPTAVSQQTSVGCS
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MPLAFKRTRDFMHTDQQPVLLTIKKAKNGLGAGTTTRHPTVSARREFEELISAIQKLPFSSLLPAHFHLLARTMDVRALVSSSYFFPRTVEDIMEYMANPSVVSAIKNLLHKLGYTSLRPIQLACFEPILHQSSCILVSRTATGKTFAYLFPLLLREGFFNTTQVTSSQILVICPTRLLCEQVTTVTRTCLATLVELCPCLKSFTVCSAYSGQSQSLVNTSLELANMLVATPGILTSRQYIFTGSTIVLDEYDDLLGGSFLEDVKQILRITGELCSAPINTFTTLTKGIRIMSTSPKEIPSAQFICVSATMTDEALAQAEFLASSLSGSLPSLIIHGSINKIPSNIQHTYLLSNRADTGAIAEEKSISKLPRVIFSGRITSIWHLKQLLEDRAIKSEEELIDIVSSGSFYSKCIVFFLLRSRIEENSRKEQQGKTIFRLHGEMQQEVRDEILARFSKAPPHSGAVLFTTDLGARGLDSKDVDLVISIGLPPTIISFIHRIGRAGRMGQKSLAVTVVSKRTDFLRQIDDCFETSTFE
The following text describes a protein:
Function:
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Does not appear to be required for the formation or the maintenance of either Salmonella-containing vacuole (SCV) or the Salmonella-induced filaments (Sifs). Not required for intracellular replication in phagocytic cells.
Subcellular Localization:
Secreted. Host membrane. Note=Secreted via type III secretion system 2 (SPI-2 T3SS), and delivered into the host cell. Concentrates in detergent-resistant microdomains (DRMs) that are present on the membranes of Salmonella-containing vacuole (SCV) and Salmonella-induced filaments (Sifs).
Sequence:
MPITNASPENILRYLHAAGTGTKEAMKSATSPRGILEWFVNFFTCGGVRRSNERWFREVIGKLTTSLLYVNKNAFFDGNKIFLEDVNGCTICLSCGAASENTDPMVIIEVNKNGKTVTDKVDSERFWNVCRMLKLMSKHNIQQPDSLITEDGFLNLRGVNLAHKDFQGEDLSKIDASNADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAILFGSDLTDTKLNGAKLDKIALTLAKALTGADLTGSQHTPTPLPDYNDRTLFPHPIF
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MELNSNNASETLLNQLRSGKARFEIVDQFPHPLVEKPIARISSTLLNCSRFFARIEFPLHGTTQATKKVEHHAIQKVTGDGRCLFRALVKGMAINKGLTLNPSDERDDADELRMAVKEIICTSNNERHLYEEALISITVEQSLKRYCQRIEHSDFWGGESELLVLSKLCCQPIVVYIPEHEHRMGRWGNGFIPIVEYGAEYMKASKGGKPRKVVRLLYTGLIFLISTTFLRRGPLVIAIDIGHEEN
The following text describes a protein:
Function:
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
Sequence:
MAKESMKAREVKRAKLVARYAEKRAALKQIVRTGEPADAFEAAQKLQELPKNSNPIRMHNRCKLTGRPKGYIRQFGISRIQFREMASNGLIPGVKKASW
The following text describes a protein:
Function:
Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
Sequence:
MNALTKVKLIHELNEQEMELGDAEKLSWHAEYKESPWIFGGGLPYELTEGDIICVFSQYGEIVNINLVRDRETGKSKGFCFLCYRDQRSTILTGDNFNGIKI
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MADRFPSLEDFSAGQTEVVETNGASDENDFLARERAILGDDADQFATAQDHVATDIGDDLLGGAEGAVVGETAPEEISGFESSFPAIETQNEQVAPGGTITGTGAPFPPTGYPSYKEPEEEPAPVREWRERRDAEIARRAELSNEKKEATIKKAREDIDDFYVSYNNKTDKLRAQTRADAEQFLANREDTSAGGTSWERIAKLVDISGKGAKGGASGSGKERFRELLLDLKKDQNAPGASGI
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes; Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
WKNIKYRQDMPPPGGYGAVPYKRNLPVRGLGGFALFGLGIGLSAIGVKMLWERKVLEEFTNQESHQAELVYYPLLQAEKDRTELRLHKEKIESEALNIVGTGFDPTYEPGMGNVYHTPVYEPPLMESLSPFWQSIRLWYQ
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Positively regulates the expression of the sigY-yxlCDEFG operon upon nitrogen starvation. Also positively regulates ybgB.
Miscellaneous:
MISCELLANEOUS: Negatively regulated by both YxlD and YxlE.
Sequence:
MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPDLSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEETIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTVKSRVHKGLQQIRKEWDDE
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGSMFRSEEVALVQLLLPTGSAYNCVSQLGELGLVEFRDLNESVSAFQRRFVVDVRRCEELEKTF
The following text describes a protein:
Function:
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum. Mitochondrion outer membrane. Nucleus. Postsynaptic density. Presynapse.
Sequence:
MPTMQVFVRFNSHHSFPVDVDSSWSVLQLKEVLAARQQVPPAEIRIIFAGRELRDSFIIGECDLASHSIVHVVRGRPQLSVEAQVSSSSSQEPQSLTRVDLNPQEDGASASNTSHGAAHRHPHFFVYCKQQCKDVQPGKLRVSCATCKQGTLTLNRGPGSWDDVLLPGRIQGRCQSQGCQGTVAEFYFKCAAHPTQEEDTAAALYMIKSNTQDVPCMVCEEVSTPLILFECEDAHTSCLDCFHTYCTTRLNDRQFVQDATLGYTLPCPAECEDSLIKEVHHFRVLGDEQYERYQRFGTEECVLQMGGVLCPGRGCGAGLLPEGETRRVECVRQGAQGCGLVFCKDCLEPFHQGECRPQMEQLFGAENRIAVDPESALRSRWERESEETVRQTTKPCPNCKAPVEKNGGCMHMTCPRAQCRYEWCWLCETAWNRDCQGDHWFG
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTSQYVTEPPSSGLVDLVTSKGTISIALFPTQAPLACRNFLTLALEGFYDNLVFHRLIPNFILQTGDPSATGTGGESIYGEPFPIESHSRLKFNRRGLLGMAANQDRTNESQFFLTLDATPELTGKHTLMGKVEGKSIYTLVELVEGVELVDGDRPRYPIKLHEVRVVENPFDDLQPRTTKKQRIAEERRKKHEMETRVAEEQKRKRSKAKKNTGLLSFGAEEEAEDEVALKGPKSSHDLLKDDKHLSRQTIETSKSTKANTPAVSANISSKEKRFLAQSSSSTTPPAVTKQASKDGTSDAPHPTATLKSEHSGPSDQKASSSTGRDFLASQRAKYLSSSHPSTAKQDDSYSALLSFQSRLRTRPSSTTPIAKPLPSVGVDEVEEEAGEYGASDDDDDWRSHRLDAGGQPLVAGQNAGKDTLEDYEVLDPRDHTDRERNPKAESSRDGKRGRDWVEHDRKYQNDRSRRHREHDKHPQQRRQRSII