lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MGLLPDEARVLPPPGLVNRNSLWMGFMGYMSAITHNAIRHMPALRAGVHRQVLLTSIGVFLGYHATKYENYRNAKIDRDLREYIGHHPGEFKVQEKKTMAEVLEDFTPIR
The following text describes a protein:
Function:
May play a role in the apical hook development (Ref.6).
Miscellaneous:
MISCELLANEOUS: Seedlings over-expressing SAUR32 display reduced hypocotyl elongation and are defective in apical hook maintenance when grown in the dark.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Primarily localized in the nucleus.
Sequence:
MGTGEKTLKSFQLHRKQSVKVKDVPKGCLAIKVGSQGEEQQRFIVPVLYFNHPLFMQLLKEAEDEYGFDQKGTITIPCHVEEFRYVQALIDGERSVYNGNNHHHRHGGRDQYHHLVGCFRA
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGASTDSNIHHQSATKLIPIRQQPQPEELQTSLSLVPSDPRHSPDVPRSNSVQVQESPTESASSQETWPIGDGVMVKKMENGKADNDFVEQSVIHHLSTADKISLRDIARDRIEVIAEKMHHLPEDFLENLKNGLRIILDGNVGAQQRDEIFMLQKLVQSRTDLTGKTLIRAHRVQLEILVAINTGIQAFLHPNISLSQTTLIEVFVYKRCRNIACQNQLPADDCTCEICTTRNGFCNLCMCVICNKFDFEVNTCRWIGCDLCSHWSHTDCAIRDGKICMGSLVRIGTARSEMHFKCPACHRTSELLGWVRDVFQHCAPSWDQESLMKELDFVSRIFRGSEDLGGRKLFWKCEELKEKIKSGGLESAAACRAILMFFQENETDSMSSIENGEGGRLEAPQEACNRITEVVQEVIKKMEIVANEKMRSWKKARMDVEAFNLEVEDKAKEAEEIKLDRQRKKLQIEELEKIVRLKCAEADMFQLKANEAKREAERLQRIALAKTDKSEEEYASNYLKQRLNEAEAEKQYLLEKIKLQESSRPSQRSGGADPSQMLMYSKIQDLLYNASKPDSAK
The following text describes a protein:
Function:
Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
Sequence:
MATTLKNVKNIVPLLDRILVQRLKAEAKTAAGVLLPEKSVERLSEGRVVSVGKGGLNQEGKQVAPHVAPGDRVLLPAYGGSNIKVGEEEFTLFRDHELLAVIKE
The following text describes a protein:
Function:
Probable component of an adaptor protein complex. Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Early endosome.
Sequence:
MFSQFFILNNKGETIIFKDYRFDISKDSNEIFFKHVQSMKSEITPAFNIDGINYLYIKKREMYFVFTTRLLVSPSLGFELLNRASKIIQDYTASLTEEAIRLNFILIYELLDELMDYGVPQSTGTETLKAFVFTPPKQIKSKQLESDSIIDNFLKATNKISVPPKQGVKPIHSGSKNSSSGGSSLSTNTVSKVVNNIVDSISGAATNLHNSTSGGGSGSGVTDADGDNEIYIDLCERLTVLYSSNGTILRNEITGKIQMKSYLRGNPALSLGLSPEFTFKTIANRDESNENEIDNNNIGGVSNLSAPSSNTTSFIVDDCSFHECAGSGFQPNNTINFKPPQGDFTLLKYRISNNNYTPFLVKTNLESTIRNRFDLVVTIRSNFSNKVVPNFIFVSIPVPKSTKSLTHSLDYGSQNQKVEYKQSTQAGNLVFWSIKKLRGGMETILRIQIHVDGATSSSSNNNQQQQQPQIDVGSTLRKEIGPIGLEFSIPQFSCSTLQIKFLKMLGSNISPIRWIRYITDSKSFVSRINN
The following text describes a protein:
Function:
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Localization:
Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase (By similarity).
Domain:
The SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with XCAP-C, forming a V-shaped heterodimer.
Sequence:
MHVKSIIIDGFKSYAQRTEINGFDPLFNAITGLNGSGKSNILDSICFLLGISNLTQVRASNLQDLVYKNGQAGITKATVSITFDNYDKKQSPLGFEAHDEITVTRQVVIGGRNKYLINGVNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILAMIEEAAGTRMYECKKIAAQKTIEKKEAKLKEIQTILEEEITPTIHKLKEERSSYLEYQKIMREIEHLSRLYVAYQFVCAEETKVRSAEELKEMQDSILKLQDTMAENERKVKELGKEIAELEKMRDQEVGGALRSLEEALSEAQRADTKVQSALDLKKQNMKAEREKKRKELVKSMEEDAKVLTAKEKEVKKITDGLSSLQEASQKDVEAFTSAQQHFNAVSAGLSSNEDGEEATLAGQMMACKNETSKAETEAKQAQMKLKHAQQELKTKQAEVKKMDGGYKKDNEAFEAVKKSKEKLEVEMKKLNYEDGREEQLLEKRRGLSRDVNRLREAYESLMARFPNLQFEYKDPEKNWDSDRVKGLVASLISIKDVSTATALEVVAGGRLYNVVVDTEVTGKKLLEKGELKRRFTIIPLNKISARCLGKDTVNVAKNLVGADNVNLALSLVGYESELQKAMEYVFGTTLVCDTMDNAKKVTFDKRIMTKTVTLGGDTFDPQGTLSGGARSQNASVLVRLQELKDVQDELKAKETELQEVEKELMTLKNTVERYRQLKQQWEMKSEEAELLQTKLQQSSYHKQQEELDSLKQTIEESEETLKNTKEVQKKAEEKFKVLEHKMKNAEAERERELKEAQQKLDTAKKKADASNKKMKEKQQEVDALVLELEELKREQTTYKQQIETVDEAMKAYQEQADSMASEVSKNKEAVKKAQDELAKQKEIIMGHDKEIKTKSSEAGKLRENNNDLQLKIKELEHNISKHKKDSADAAAKVAKMLNDYEWIASEKHLFGQANTAYDFKTNNPKEAGQRLHKLQEKKEKLGRNVNMRAMNMLTQAEERYNDLMKRKRIVENDKSKILTTIEELDQKKNEALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQSVLDGLEFKVALGNTWKENLTELSGGQRSLVALSLILAMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFRHSQFIVVSLKDGMFNNANVLFKTKFVDGVSTVARFAQNQNGGSSAGQQRSDKSKTKERRNRMEVDK
The following text describes a protein:
Function:
Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MADWNRGHGSGAVDEMLDVENKLLADNLATKVSRLKSLAFEIDKEAEDQNSYLDGMDSNFLSTTGLLTGSVKRFSTMVRSGRDNRKILCYVSIGLVLVFFILYYLVSRTQT
The following text describes a protein:
Function:
A minor component of the functional amyloid in this bacterium. Upon overexpression of the endogenous six-gene locus (fapA-fapF), cells form large clumps during liquid growth, make large amounts of biofilm and produce amyloid fibrils.
Subcellular Localization:
Fimbrium. Secreted. Note=Part of an extracellular amyloid fibril.
Sequence:
MLREHAMYTHHCFVLACCLGAALPAPASDLFAPAELSDQELSQLRGRYVLPGRIVSFGVTMSSTWQNASGQVLGARVDLQVRQNLARPVLNVTLVDRPGDAPPPVAGNGQVLGGAGLAQTQGVSQSIRTAGDHNSASNGVSIEVRHGEAPPPLSGGTPLEGALALSGETGTVKVTPNGGALQLAIQASGQGASLQSLGAGGLVQSVALSGNRNLVQNLAALEVMLKDRPGADPALNCAWEQLRALRPSGY
The following text describes a protein:
Function:
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPTRSLPTFLTLLLLASIDWVSKLVVLLKSCQLSPHSSAFLYSYVWGHFSFLIIPSFNEGAAFGLFTQYKIPLLIFRVCVILGLALFLRIKYKSLHRRTRVALTLILAGALGNVGDILLYGKVVDFLSLSYYSWRFPSFNLADAFISIGTLLLIGHLYFTKESKKYF
The following text describes a protein:
Function:
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.
Subcellular Localization:
Secreted.
Sequence:
MRSVRFCFLLCCWRAACGAGCELTNVTIAVEKEECRFCISVNATWCAGYCYTRDLVYKDAARPSIQKTCTFRELAYETVRVPGCARHADSLHTYPVATECHCGRCDSDSTDCTVRGLGPGYCSFGEPQQ
The following text describes a protein:
Function:
Plays a role in determining ER morphology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein; Cytoplasmic side.
Domain:
The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.
Sequence:
MGALLAKWRAKPSTVEVLEKMEKDIQSLEEFSDKNQKLLKIWVARLFFYSSILYIITSLAVYLLYLPDGMTARLLTTLLFMLFPVLIWFVRTLLILWFSRRTERNNDALEIVKAEKKKIIQDLRQRTAAQRNISVSTPVNPDQESPQVPGLLAATPALQRDTSGPGGPPERSVQPTPQSNILQRRPGSPVTAVSGMALHPPGPPLARPILPRERGAMDRVIEYLVGDGPQNRYALICLLCFSHNGMELKEEFEYVAFRCAYCYFLNPARKTRPQAPRLQEINFDRQRHRTDSQGSVSALQPPAAEQQESQHSPLAMEENSPVQAEDKEIEEDSTCSEQQWEKVPDDSEKDKSSVTELNPPLPAPAANEREESFM
The following text describes a protein:
Function:
Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MESEMSDPQPLQEERYDMSGARLALTLCVTKAREGSEVDMEALERMFRYLKFESTMKRDPTAQQFLEELDEFQQTIDNWEEPVSCAFVVLMAHGEEGLLKGEDEKMVRLEDLFEVLNNKNCKALRGKPKVYIIQACRGEHRDPGEELRGNEELGGDEELGGDEVAVLKNNPQSIPTYTDTLHIYSTVEGYLSYRHDEKGSGFIQTLTDVFIHKKGSILELTEEITRLMANTEVMQEGKPRKVNPEVQSTLRKKLYLQ
The following text describes a protein:
Function:
Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
Sequence:
MPTLSEPMSTSTAITEQEFGRFQRFIFEAAGISISSGKKAMLCGRLGKRLREHQFDNYTQYLQLLESRQDRDEIQTAIDLLTTNETYFFREPKHFDLLRRLADDHRGGLPLRCWSAASSTGEEAYSMAMVLDDALQGRAFEVVGTDISSRVVAKARTGHYALQRIDGIPQAYLKRYCLRGQGEYAGTLLVERRLRDRVKFVHANLNAALPMLGSFDVIFLRNVMIYFNGQTKREVILRVLANLKPGGHFCIGHSESLSELDIDLIQVAPSIFRKA
The following text describes a protein:
Function:
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVEANSSSALSLSATWWNETSSNGTLRGGSHQVYVTSLYLAAYCAVFLLSMVGNVAVVIMVLKISKNGGTRACCFIFNLVMCDLLVGIFCVPFTLIQDLLTDGGLADLMCKMTSTVQGIAVCCSVFTLTTVAILRYRWRDHQQQMEISGTTVLVVSIAMWVVAVLFSSPELVVRRTIQPDPEVGGKPACVDVWPSSQLKMVYKGFLFALCFLGPFFVIGYLWVTVGIKTCCASREPQRDVVIERSHSPSATPTRRKGTKYFRMMKVIVAIFCFLWLPLYVSWTLEAYGDYSWFLKEKVKGYIYPIALWTAFSNSLINPFICGYYIKNVGKTCRKKPRRSRQARKNWESSISSNNSSSDGKLGHIELNSVCGSTEKPDDVRDRILVLPTDKDVSLDPVMRLPTDCSTEPLTRTEVKE
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.
Subcellular Localization:
Nucleus.
Sequence:
MTMSSFLINSNYIEPKFPPFEEYAQHSGSGGADGGPGGGPGYQQPPAPPTQHLPLQQPQLPHAGGGREPTASYYAPRTAREPAYPAAALYPAHGAADTAYPYGYRGGASPGRPPQPEQPPAQAKGPAHGLHASHVLQPQLPPPLQPRAVPPAAPRRCEAAPATPGVPAGGSAPACPLLLADKSPLGLKGKEPVVYPWMKKIHVSAVNPSYNGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRRMKWKKDHKLPNTKMRSSNSASASAGPPGKAQTQSPHLHPHPHPSTSTPVPSSI
The following text describes a protein:
Function:
Involved in the binding of tRNA to the ribosomes.
Sequence:
MSLASRRKVRIRLYGTNPADVEQVAREIVDLAKKMGVQVRGPIPLPTRRLIVTVRRAPSGQGYHTFDHWEMRISKRLIDIEASERVLRRLMTIRVPDTVKIELQLI
The following text describes a protein:
Function:
Involved in the modulation of the activity of the glucose-phosphotransferase system (glucose-PTS). Interacts with the transcriptional repressor Mlc, preventing its interaction with DNA and leading to the modulation of expression of genes regulated by Mlc, including ptsG, which encodes the PTS system glucose-specific EIICB component; Shows zinc-dependent metallopeptidase activity (By similarity). In vitro, can cleave several artificial substrates. The greatest activity and specificity is observed for L-alanine fused to 4-nitroanilide (L-alanine-pNA). Shows significantly lower activity towards L-arginine-pNA, L-proline-pNA, hippuryl-L-phenylalanine and hippuryl-L-arginine, and cannot use FTC-casein. Mlc does not appear to be a biologically relevant peptidase substrate. Biologically relevant targets may have a function in growth transition under changing environmental conditions.
Miscellaneous:
MISCELLANEOUS: The two functions, Mlc binding and proteolysis, are clearly distinct from one another.
Subcellular Localization:
Cytoplasm.
Domain:
The C-terminal part of MtfA is sufficient for Mlc binding.
Sequence:
MIKWPWKVQESAHQTALPWQEALSIPLLTCLTEQEQSKLVTLAERFLQQKRLVPLQGFELDSLRSCRIALLFCLPVLELGLEWLDGFHEVLIYPAPFVVDDEWEDDIGLVHNQRIVQSGQSWQQGPIVLNWLDIQDSFDASGFNLIIHEVAHKLDTRNGDRASGVPFIPLREVAGWEHDLHAAMNNIQEEIELVGENAASIDAYAASDPAECFAVLSEYFFSAPELFAPRFPSLWQRFCQFYQQDPLQRLHHANDTDSFSATNVH
The following text describes a protein:
Function:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MGAATKLAFAVFLISCSSGAILGRSETQECIYYNANWEKDKTNRSGIEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRNDCIEKKDSPEVFFCCCEGNMCNERFFYFPEMEVTQPTSNPVTPKPPLFNTLLYSLVPIMGIAVIVLFSFWMYRHHKLAYPPVLVPTQDPGPPPPSPLMGLKPLQLLEIKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEIYSLPGMKHDNILQFIGAEKRGTSIDVDLWLITAFHEKGSLTDFLKANVVSWNELCHIAQTMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTASDGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRECWQKHSGMAMLCETIEECWDHDAEARLSAGCVEERIIQMQKLTNIITTEDIVTVVTMVTNVDFPPKESSL
The following text describes a protein:
Function:
Involved in a signal transduction pathway that regulates morphogenesis and controls entry into the culmination stage. May act via the regA pathway, being activated by a morphogenesis-stimulated ligand, reducing phosphodiesterase regA levels and allowing cAMP level to rise to promote the culmination stage. This protein probably undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain.
Subcellular Localization:
Nucleus membrane; Multi-pass membrane protein.
Sequence:
MIELNNHSKINKNENNTNTRNNSSNNNNNNNNINKTNTNKYFEYNQNSIIYSSIPNSFLSHHPNSVGSQCLSLNSFLPPKPPILLSIFNSDTIGNNNNNNYSSSSSRNNSSGCSSSNNNNNNNNNNNNNNNNNNNNNNNNCNIEQYKNNQKQPKQQQQQKDQTIATQHRISLSSSSSSSSLSSSSSSSSVKQSFQIVKRLFGSLSEYMFPQKDEILYETDPYYLYQDDTQSNDSNEFYDDTDIGSDIDEANLNNTYNIQNCNKTLYNKQQQQAHFVNMNKNVNSNNGTGNSNQSNNVNKNQQNNNNNNNNNSHNNNNGNQNSSSSSSNSGASGSGGNGNNNNNNNNNNNNNNNNNNNSNSNSNNNSKSNNNNKKEGKDGATMNGSHPLIPFRKKPAQVPSPCFRMNSPNSDNDQYLDQLALENSSKKSLVVYNTDNLDQWKHSHLNENFDILQNDLIDIQQQQQQQQQQDNTLQYSSPINKRQEQEQQHIPFQFTTEQQQQLQQQQQQQQQNKTKQHPILLQRQQQQKQKQQQQQQIQQEQIGNNNSNNNNNINNNNNINNNYNNVNDLMNKFEIDQKQHDSQQNLVEEKRTPSFHEHNIIFNSFNFICSIVLDGSNIKSTEKYKAKLIIGFCFTILSFIPSWIIFFWLSGINKPAVMAIIAMPMSISSLVILKRTGSIHYPCHILCFTLCFALTINSYYTGGHQSTIRLLMSTVPIISALVLGRKASIQWSLMVLSIYLLFFVANLYGHEYVQGIPSIIIRSHMNFIIDVTIIIMTLIFTLCYQYFIDEAHRETKLKNAQLTIAKDAAIEAYQARQEFLATMSHEIRTPLNGLIGMATLLRDSHNLPPEEKTMAKAVKSCGDILLRLVNDILDLSKLEANQMGLEHIPFRMRELTQQICHVLSGQANEKNIHLSCEVSDKIPSILLGDSGRILQILMNLTGNALKFTQSGYVKIIIDLIEEESELVSLKKGEYNISFRVKDTGIGVPVESHQKIFEAFVQADPSDSRKYGGSGLGLYLCAKLVRLMKGEIGVYNNPDCDGSTFWFILPLEEGTDQSMQQMNNGARHKAFPQDCVKVLIAEDNIINQRVAVKFLEKIGIKAEVAGNGNEVLEILERQHYDLIFMDFQMPILDGLRCSKTIREFEQNHKWNRICPSIFICGLTANTMSTDKKRCFDHGMNHFISKPFQLEQLRSAIEMAIEHKQRNLMNLNIRN
The following text describes a protein:
Function:
Probably facilitates diffusion of 1,2-propanediol (1,2-PD) into the cell (Probable). Modeling suggests active transport of 1,2-PD is required at low extracellular concentrations to allow maximal growth and saturation of PduP/PduQ within the bacterial microcompartment (BMC); this protein may be the cellular transporter (Probable); The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
MNDSLKAQCGAEFLGTGLFLFFGIGCLSALKVAGASLGLWEICIIWGLGISLAVYLTAGISGGHLNPAVTIALWLFACFPKQKVLPYIIAQFAGAFGGALLAYVLYSSLFTEFETAHHMVRGSVESLQLASIFSTYPAAALNVWQAALVEVVITSILMGMIMALTDDGNGIPKGPLAPLLIGILVAVIGASTGPLTGFAMNPARDFGPKLFTWLAGWGNMAMSGGREIPYFIVPIVAPVIGACAGAAIYRYFIGKNLPCNRCEL
The following text describes a protein:
Function:
Part of the dynein complex of respiratory cilia.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MPPKQPLRRQSVSVGRGTRKRDEDSGTEVAEGADEWAQSKATVRPPDQLELTDAELKEEFTRILTANNPHAPQNIVRYSFKEGTYKLIGFVDQLAVHFSQVGNLIPKDSDEGRRQRYRNNLVTGSEESAKLVISEAEVVEEEDEPKEAEAGSQTDLPAAEAAEKVAEELMTPKQPKERKLTNKFNFSERASQTFNNPLRDRECQMEPPPRTNFSATANQWEIYDAYVEELEKQEKTKEKEKAKTPVAKKMGKMAMRKMTSMESQSDDITKVTQAAKIVERMVNQNTYDDVAQDFKYYEDAADEYRDQEGTLLPLWKFQNDKAKRLAVTALCWNPKYNDLFAVGHGSYDFMKQSRGMLLLYSMKNPSFPEYIFSSESGIMCLDMHVDHPYLVVVGHYDGNVAIYNLKKPHSQPSFRSSAKSGKHTDPVWQVKWQKDDMDNNLNFFSVSSDGRIVSWTLVKSELVHTDVIKLKVEGSTTESLEGLQLYTVGCGTAFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMAVDAVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAAVTTNGKTHVFDLSINKYEAICNQPVVAKKKNKITHVQFNPIHPIIIVGDDRGHVTCLKLSPNLRKMPKLLRTTVGNNGCEVTAFGGSSRQQPRPSKVSSLCEVKGQDPPGGMTIPRLSPVRGND
The following text describes a protein:
Function:
Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR.
Subcellular Localization:
Nucleus.
Sequence:
MTEVDVVLPEGVAEPTTKLASASSSPKQSKPSADDVEQQVTTVEDDEEQVVEEQQEEDVHLPEAPSNEKLELLSAGGKDISKEDVAQASPQAPVADEIMEVDGTEDVEENEVENDDEDSQITSSSSKEPKLDEEDEEATTNGDGDHEPEDEDDAQKIGSTAENSCEAEDPLGAVTVPDDELASGKKAHLDGEESVASEGVVEEEPPAKQENGFGASPNQKENGQASIAEARAAIAPSDGGVVNLDEDSDEEMEDITEHKEPAKPTEKAAKPASSSGGESSDDAVLIASDSDTESAAPPPPVKKLPPVVKAIPPPPVQDDEDDDDDDDCVVIEDDTPLSISPSGKRKSDLDDLQLQQPSHKRQRSSTPSGMGQLTIKDARSLMPLDGSPSSVSGPRDSIYPVTITNAVTGAATNLGVVPPKLVPMAGGMSASPVQLNPPTLSLTGLPSMTNNANLLPGLTDDMFVLEAPSFIVPYIYEKPPRENICEVVKAIETKYALSAEDLAEADKGDEFDMMTEQNKEDKPADQADESGKKKKKKRGDDESWSEQSDDDDDEDDDDDSESGVRTKVLIKEANDDLSALKVAIKPAAALATAGGVSVNNPGGNKPGQENYFESPLGKFFMDIGVGLVQEYVQSDLLRLQKRKMRKAQVQNSKEFEMAINALSGNLQASKTKNAPFKFRMKRCEFCNFKSESAMAMANHYETPHMNGVLYKCNFCTFEIRNATEIVYHMEAVHNIKARLIKPLPYHQCPNCGFEDNGKAKLARHQPVCAKKFRPELNLAPPNDWEAPAKIPRIKPRHGLVGTATAYQAMAAQAAAQKAALANIQQQQAAAQARNNLQAAALAAQNAAKMRQRAPQPPKQNIVRNPAPVRGGNAMNAGLSLPNSYQLAAGQLVQASKKPMAGQPSISITPLPRQSSVGAGAGASSSKAPQAAAGMKPGQSPSGNNKAQFVICEICDGYIKDLEQLRNHMQWMHKVKIHPKMIYNRPPLNCQKCQFRFFTDQGLERHLLGSHGLVTSSMQEAANKGKDAGRCPVCGRMYQWKLLNHVSRDHHMTLKPAHLSYKCTVCTATFGMYKQFETHVYTAHSTVARKAMDSKKNSAQSSGSGSGAGMSRSSLGAANDSLLKPLKINDEITIIPQPASKPRITNMESHVID
The following text describes a protein:
Function:
Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, actin patch. Note=Localizes to cortical patch-like structures. Enriched at sites of polarized growth, like the growing hyphal tips and sites of septum formation (By similarity).
Domain:
The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force; The tail domain participates in molecular interactions that specify the role of the motor domain (By similarity). It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding myosin tail domain (also named TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).
Sequence:
MGHSRRPVGGEKKSRGFGRSKVADVGDGRQAGKPQVKKATFETTKKKDIGVSDLTLLSKISNEAINDNLKLRFEHDEIYTYIGHVLVSVNPFRDLGIYTDNVLDSYRGKNRLEVPPHVFAVAESSYYNMKSYKDNQCVIISGESGAGKTEAAKRIMQYIASVSGGSDSSIQQTKDMVLATNPLLESFGNAKTLRNNNSSRFGKYLELEFNANGEPVGANITNYLLEKSRVVGQIANERNFHIFYQFTKAAPQKYRDMFGVQQPQSYLYTSRSKCFDVPGVDDNAEFRDTLNAMGVIGMSEAEQDNVFRMLAAILWIGNVQFAEDDSGNAAISDQSVVDFVAYLLEVDPAQVNKALTIRIMETARGGRRGSVYEVPLNTVQALAVRDALSKAIYFNLFDWIVERVNQSLTAREPVANSIGILDIYGFEIFEKNSFEQLCINYVNEKLQQIFIQLTLKAEQDEYAREQIQWTPIKYFDNKVVCSLIEDKRPPGVFAALNDACATAHADSGAADNTFVGRLNFLGQNPNFENRQGQFIVKHYAGDVSYSVEGMTDKNKDQLLKDLLNLVGSSGNQFVHTLFPNQVNQDDKRRPPTASDKIKASANDLVATLMKAQPSYIRTIKPNDNKAPREYNVGNVLHQIKYLGLQENVRIRRAGFAYRQTFNKFVERFYLLSPKTSYAGDYTWTGDAESGARQILKDTSIPAEEYQMGITKVFVKTPETLFALEAMRDRYWHNMAIRIQRAWRNYLRYRIECAIRIQRFWRRTTGGLELLKVRDQGHQVLQGRKERRRMSLLGSRRFLGDYLGIGNKGGPGEMIRNGAGISGSDDILFSCRGEVLISKFGRSSKPSPRILVLTNRHVYIVAQILVNNQLQISAERTVPIGAIKAVSTSNLKDDWFSLIIGGQEPDPLINCVFKTEFFTHLQTALRGQLNLKVSENIEYNKKPGKLATVKAIKDPAASPNVDTYKSHTIHTSPGEPPSSVSKPTPKAKQVAARPVTKGKLLRPGGPGGGPSKLASRPASRPTPKPQPLPQSQPATAQPIPAPQPAAVPRPVPQPVAAAAASHTRNASSGSVRAPPPPPPASPPAPKKATAKALYDFTSAQSNELDIRAGDVVQIVSKEGNGWWLCMNMATSVQGWTPQAYLEEQVAPTPKPAPPPPPPAAPRASPVPSANGAAATAAAAKAKPAPPAPPAKRPNMAGRKAVPAPPPAPRDSAVSMNSQDSSGGSGRGTPNSTSNASLAGGLAEALRARQHAMQGKHDDDDEW
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSGDQPPVVTMLQPMNSPLDPYNSMSPLKPEVLLPFSRYLPQTSNSGDLFGPSMSSTHKLHQIQMSSSELRLPHLEPVGGAWPLQRLWEAGLSNSEPIAPIDSFNWLTQVSRLGYHVPHPLPNQMMHGQRYGFDGEERTRTGAYDCWLQQFSQGRLGFSLPGFCIRNEAEIQSTTFPRIPQRNETGGSEVKQEFGRQTTQRRQPMRRRRRSHVVEKLLECSYCGKRFRLKHQLDTHFRVHTGEKPFSCTLCNQRSRDYSAMIKHLRTHGVPSPYCCTLCSEFCSSRSSMHQHMDSHPATDIPANWTITDSCLYSSKQ
The following text describes a protein:
Function:
Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Recycling endosome. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.
Sequence:
MAAAATMAAAARELVLRAGASDVEEEEGPLGGGSGLQEPLQLGELDITSDEFILDEVDVHIQANLEDELVKEALKTGVDLRHYSKQVELELQQIEQKSIRDYIQESENIASLHNQITACDAVLERMEQMLGAFQSDLSSISSEIRTLQEQSGAMNIRLRNRQAVRGKLGELVDGLVVPSALVTAILEAPVTEPRFLEQLQELDAKAAAVREQEAMGTAACADVRGVLDRLRVKAVTKIREFILQKIYSFRKPMTNYQIPQAALLKYRFFYQFLLGNERATAKEIRDEYVETLSKIYLSYYRSYVGRLMKVQYEEVAEKDDLMGVEDTAKKGFFSKPSLRSRNTIFTLGTRGTVISPAELEAPILVPHTAQRGEQRYPFEALFRSQHYALLDNSCREYLFICEFFIVSGPAAHDLFHAVMGRTLSMTLKHLESYLADCYDAIAVFLCIHIVLRFRNIAAKRDVPALDRYWEQVLALLWPRFELILEMNVQSVRSTDPQRLGGLDTRPHYITRRYAEFSSALVSINQTIPNERTLQLLGQLQVEVENFVLRVAAEFSSRKEQLVFLINNYDMMLGVLMERAADDSKEVESFQQLLNARTQEFIEELLSPPFGGLVAFVKEAEALIERGQAERLRGEEARVTQLIRGFGSSWKASVESLSQDVMRSFTNFRNGTSIIQGALTQLIQLYHRFHRVLSQPQLRALPARAELINIHHLMVELKKHKPNF