lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.
Subcellular Localization:
Nucleus.
Sequence:
MQRMIQQFAAEYTSKNSSTQDPSQPNSTKNQSLPKASPVTTSPTAATTQNPVLSKLLMADQDSPLDLTVRKSQSEPSEQDGVLDLSTKKSPCAGSTSLSHSPGCSSTQGNGRPGRPSQYRPDGLRSGDGVPPRSLQDGTREGFGHSTSLKVPLARSLQISEELLSRNQLSTAASLGPSGLQNHGQHLILSREASWAKPHYEFNLSRMKFRGNGALSNISDLPFLAENSAFPKMALQAKQDGKKDVSHSSPVDLKIPQVRGMDLSWESRTGDQYSYSSLVMGSQTESALSKKLRAILPKQSRKSMLDAGPDSWGSDAEQSTSGQPYPTSDQEGDPGSKQPRKKRGRYRQYNSEILEEAISVVMSGKMSVSKAQSIYGIPHSTLEYKVKERLGTLKNPPKKKMKLMRSEGPDVSVKIELDPQGEAAQSANESKNE
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MAGRGRGRGWGRGSGFVIRDDDGNMVLPDKLSGPPPLFPPIENLPEVPEIGDEEEELLNRRRRLESAWLYSPYHIEKPKSKTVGLAAEIERYADRYRRNPHAIRAPLSSVLKLTPKHFPAELLGPEKGKGRGGGAAQATAASAPWKSAPLATTDIQRLERLANLEQKIEANGDKATEKPKEGEGGEEDEEEALDEEDEMGEGDYEQGYQFEDDELYGDDDDAFGNDEGPTF
The following text describes a protein:
Function:
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MRSRSNSGVRLDGYARLVQQTILCYQNPVTGLLSASHEQKDAWVRDNIYSILAVWGLGMAYRKNADRDEDKAKAYELEQNVVKLMRGLLQCMMRQVDKVEKFKHTQSTKDSLHAKYNTATCSTVVGDDQWGHLQVDATSLFLLFLAQMTASGLRIIFTLDEVAFIQNLVFYIEAAYKVADYGMWERGDKTNQGIPELNASSVGMAKAALEAIDELDLFGAHGGRKSVIHVLPDEVEHCQSILFSMLPRASTSKEIDAGLLSIISFPAFAVEDVNLVNVTKNEIISKLQGRYGCCRFLRDGYKTPREDPNRLHYDPAELKLFENIECEWPVFWTYFIIDGVFNSDAVQVQEYREALEGILIRGKDGIRLVPELYAIPPDKVDEEYKNPHTVDRVPLGKLPHLWGQSLYILSSLLAEGFLATGEIDPLNRRFSTSVKPDVVVQVTVLAENNHIKELLKKHGVNVQSIADIHPIRVQPGRILSHIYAKLGRNKNMKLSGRPYRHIGVLGTSKLYVIRNQIFTFTPQFTDQHHFYLALDNEMIVEMLRIELAYLCSCWRMTGRPTLTFPITHTMLTNDGSDIHSAVLSTIRKLEDGYFGGARVKLGSLSEFLTTSFYTYLTFLDPDCDEKLFDDASEGSFSPDSDSDLGGYVEDTCNQESQDELDQYINHLLQSTSLKCYLPPLCKKTEDSHVFSAIHSTRDILSVMAKAKGLEIPFVPMALPTKVLSAHRKSLNLVDSPQPLLKKAPEDDFQFPRDDRGDVDCEKLVEQLKDCSNLQDQADILYILYVIKGPSWDTNLSGQHRVTVHNLLSELYGKAGLHQEWGLIRYISGLLRKKVEVLAEACTDLLSHQKQLTVGLPPEPREKTISAPLPPEELTKLIYEASGQDISIAVLTQEIVVYLAMYVRAQPSLFVEMLRLRIGLIIQVMATELARSLNCSGEEASESLMNLSPFDMKNLLHHILSGKEFGVERSMRPIHSSTSSPAISIHEVGHTGVTKTERSGINRLRSEMKQRSSTPSSPTGTSSSDSGGHHIGWGERQGQWLRRRRLDGAINRVPVGFYQKVWKILQKASRAERLECVCVCVHTFNPILESKCAFCLQCHGLSIDGYVLPSSTTREMTPQEIKFAVHVESVLNRVPQPEYRQLLVEAIMVLTLLSDTEMGSIGGIIHVDQIVQTANQLFQQDQVSIGATDTLEKDQATGICHFFYDSAPSGAYGTMTYLTKAVASHLQELLPNSGCQMQ
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Sequence:
MVVLAAAICTKNGKALLSRQFSEMTKSRVEGLLAAFPKLIGLGRQHTFIETENIRYVYQPLESLYIVLITNKNSNILEDLETLHLLAKLVPEYSNFDEYDISKNAFELIFTFDEVIAMGYKERVTLQQIKHFISMESHEEERFRMEEKIKQKEAQILASSKAKEIERMRHEEMLRGKRSGGYTGISGGGGMGSGGMGSNQYRDNDRDNYHSNNNNNNNNNNNNNNNNNNNRDRDRGDSPNTSRPSAASSGSQGGMILGGKSGTNKNSAIAQVLKEEKIVEKVEDVEQLLDSQISQIPETPTVPQEGVHITVEESFTSFVESDGTVESIDIKGGLSVQINDQSLGKVKVNLKQGKLSKQFQFITHPNIDKALFGEQSVLRLRDGGKGFPSGGILKWRCKTNQESMMPIRVNCWPSPGRDSTTVNLEYDSLVGYELKSVFIVIPNPTSNAPIINQFDGLYEYDNKQKCVIWKIPLIDDSNRQGSMEFSVKGNTQSFFPVKIQFTASQTICDTTVGSVFVEDSNQSTNFSTETTLSVDTYEIK
The following text describes a protein:
Function:
Cleaves the beta-1,4-linkages between beta-D-galactose and alpha-L-3,6-anhydro-galactose residues in agarose. Cleaves agarose in a random manner with retention of the anomeric-bond configuration, producing beta-anomers that give rise progressively to alpha-anomers when mutarotation takes place.
Subcellular Localization:
Secreted.
Sequence:
MKKNYLLLYFIFLLCGSIAAQDWNGIPVPANPGNGMTWQLQDNVSDSFNYTSSEGNRPTAFTSKWKPSYINGWTGPGSTIFNAPQAWTNGSQLAIQAQPAGNGKSYNGIITSKNKIQYPVYMEIKAKIMDQVLANAFWTLTDDETQEIDIMEGYGSDRGGTWFAQRMHLSHHTFIRNPFTDYQPMGDATWYYNGGTPWRSAYHRYGCYWKDPFTLEYYIDGVKVRTVTRAEIDPNNHLGGTGLNQATNIIIDCENQTDWRPAATQEELADDSKNIFWVDWIRVYKPVAVSGGGNNGNDGATEFQYDLGTDTSAVWPGYTRVSNTTRAGNFGWANTNDIGSRDRGASNGRNNINRDINFSSQTRFFTQDLSNGTYNVLITFGDTYARKNMNVAAEGQNKLTNINTNAGQYVSRSFDVNVNDGKLDLRFSVGNGGDVWSITRIWIRKVTSNSANLLAAKGLTLEDPVETTEFLYPNPAKTDDFVTVPNSEIGSSIIIYNSAGQVVKKVSVVSENQKISLEGFAKGMYFINLNGQSTKLIVQ
The following text describes a protein:
Function:
Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein.
Sequence:
MHLLPELASHHAVSIPELLVSRDERQARQHVWLKRHPVPLVSFTVVAPGPIKDSEVTRRIFNHGVTALRALAAKQGWQIQEQAALVSASGPEGMLSIAAPARDLKLATIELEHSHPLGRLWDIDVLTPEGEILSRRDYSLPPRRCLLCEQSAAVCARGKTHQLTDLLNRMEALLNDVDACNVN
The following text describes a protein:
Function:
Transcription factor that controls embryo growth. Regulates endosperm breakdown and embryonic epidermal development. Regulates the expression of SBT2.4/ALE1. Involved in embryonic cuticle formation upstream of SBT2.4/ALE1. Does not seem to be a general regulator of endosperm patterning. May control specific signaling pathways that coordinate embryo invasion and breakdown of surrounding endosperm tissues. Required for the production the embryo sheath, an extracuticular endosperm-derived structure at the surface of the embryo. Acts upstream of KRS.
Subcellular Localization:
Nucleus.
Sequence:
MTNAQELGQEGFMWGISNSDDSGGGCKRIEKEPLPSHPSHPSPEIQTTTVKKGKKRTKRNDKNHEEESPDHEIHIWTERERRKKMRDMFSKLHALLPQLPPKADKSTIVDEAVSSIKSLEQTLQKLEMQKLEKLQYSSASTNTTPTTTFAYAPSSSSSPTALLTPISNHPIDATATDSYPRAAFLADQVSSSSAAAANLPYPCNDPIVNFDTWSSRNVVLTICGNEAFFNLCVPKHKPGVFTSVCYLFEKYNMEVLFANVSSNVFWSTYVIQAQVNPSCENQLLGNGLGVVDVFKQVSQELVLYFSSL
The following text describes a protein:
Function:
ATP-dependent RNA helicase. Is essential for the directed and fasciculated early outgrowth of the bolwig nerves, as well as for its navigation at later stages. Is required during post-transcriptional gene expression. Plays a role during morphogenetic process, apoptosis and the establishment of cell polarity.
Subcellular Localization:
Nucleus.
Sequence:
MAHVKRYRRSSKSSEEGDLDNEDYVPYVPVKERKKQHMIKLGRIVQLVSETAQPKSSSENENEDDSQGAHDVETWGRKYNISLLDQHTELKKIAEAKKLSAVEKQLREEEKIMESIAQQKALMGVAELAKGIQYEQPIKTAWKPPRYIREMSEEEREAVRHELRILVEGETPSPPIRSFREMKFPKGILNGLAAKGIKNPTPIQVQGLPTVLAGRDLIGIAFTGSGKTLVFVLPVIMFALEQEYSLPFERNEGPYGLIICPSRELAKQTHEIIQHYSKHLQACGMPEIRSCLAMGGLPVSEALDVISRGVHIVVATPGRLMDMLDKKILTLDMCRYLCMDEADRMIDMGFEEDVRTIFSFFKGQRQTLLFSATMPKKIQNFARSALVKPVTINVGRAGAASMNVTQQVEYVKQEAKVVYLLDCLQKTAPPVLIFAEKKQDVDCIHEYLLLKGVEAVAIHGGKDQEERSRAVDAYRVGKKDVLVATDVASKGLDFPNVQHVINYDMPDDIENYVHRIGRTGRSNTKGLATTLINKTTEQSVLLDLKHLLIEGKQEVPDFLDELAPETEHQHLDLGDSHGCTYCGGLGHRITECPKLEAVQNKQASNIGRRDYLSNTAADY
The following text describes a protein:
Function:
Constitutes a host TLR2 agonist (toll-like receptor), shown experimentally for human and mouse. In host cells full-length (acylated) protein acts as a TLR2 agonist, inducing human and murine macrophages to produce cytokines, inducing murine dendritic cell maturation and cytokine production and inhibiting antibody processing in murine macrophages. Binds diacylated phosphatidyl-myo-inositol mannosides (PIMs). Does not induce murine macrophage apoptosis or necrosis. Non-acylated protein does not act as a TLR2 agonist. Requires only host TLR2 as receptors to elicit host response in mouse, although TLR6 may play a redundant role, also requires CD14 and CD16 as accessory receptors.
Subcellular Localization:
Cell membrane; Lipid-anchor. Note=May be shed from the cell surface in infected host cells.
Sequence:
MKHPPCSVVAAATAILAVVLAIGGCSTEGDAGKASDTAATASNGDAAMLLKQATDAMRKVTGMHVRLAVTGDVPNLRVTKLEGDISNTPQTVATGSATLLVGNKSEDAKFVYVDGHLYSDLGQPGTYTDFGNGASIYNVSVLLDPNKGLANLLANLKDASVAGSQQADGVATTKITGNSSADDIATLAGSRLTSEDVKTVPTTVWIASDGSSHLVQIQIAPTKDTSVTLTMSDWGKQVTATKPV
The following text describes a protein:
Function:
Probably involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.
Subcellular Localization:
Endomembrane system. Secreted.
Sequence:
MASWRTCTTFAVFTLVVLCVWCDVAEGLYTHQFALIVRGGRSTADRLSEKYGYINHGQIGSLEDHYMFSHQKVFKRSTMASTGAHTNIADEPEVEWFEQQVLRKRVKRDSTHLHLFTDSLWSDQWYMDGNFTGDSRPTASMNIQQAWDMGYTGAGIVITIMDDGLEYTHTDIRNNYDSEASYDFVSRDADPIPVYIPMKEDNMHGTRCAGEIVMQPNNSKCGVGIAFGAQIGGIRMLDLMITDEMEGSSLSFNLQHVDIYSASWGPDDGGYTVEGPAEITQTAMRTGVANGRDGKGSIFVWASGNGGADHDDCNADGYANSIYTLVVSSTTENQDRPFYSEHCSASLASTYSSGNKNQKMVVTTDLHNQCIGNFSGTSASAPMAAGIISLALQANGNLTWRDVQYLVVITSKRHQLSGEWTTNGAGYEASHWFGFGLMNAAAMVEKAKTWETLPEQLTCSKFADNVDQSYLEMFSSFIRRQKNYNSELEVTSCTDPFQGGAIQHLEHVQLTLQLNARRRGDVVVKLTSPSGTTSTLLSQRFKDRSRIGFKRWTLMSVHFWGESPIGTWRIQIGNGEYNALNVRMVRLTLRGTESLPASLLPSPDTTTMAPHEEETEEQEGEGAGEVIRRPGRPELQSTPGRGRHVSPLRVVSETLQRDVRAASSSSLSWDSSWWWSSSDWESFQECHEECLYGCSGPNADECYKCRHYKDRDTLNCVPTCPDGQFTPPELHIRCGRCSVHCKTCSGNSKYHCLSCATGLFLGDNNDCVQACETGYYKDPFFQMCRQCSPLCRSCEGNENQCTSCIDGAVLRGSQCITRCMESEYMVDERCQSCHPSCFSCNGGLETQCTACYNDYVHKDMRCVLPTQCSEGYYIVNSFDAGSRQCLRCHSTCKACQGPSFTDCVDCHQGFFLVGGACLQTCENGKFLDNGNCESCSDGCVLCADEHHCIQCAASKVLRSAVIDDVADSIICREGCEDGKYSMGGECFPCHSTCETCNGGGIMDCTQCKQSIDMPLKYLLEGACVHYCPAGYFKYDRGDIALIHTCELCDDSCKTCTGYGIDECTECEDGLSRDNENQRCVEPSDFECTVPNCDSCLNGIVDVCQTCAESYYLDNAACVLLCPPGKVAVPHTRRCELCHPTCRTCEGSPDTCTSCDDEYFYDDFDNLCLTQCPEDMYDDALRNCQDCDDKCASCVGAGPDNCKICYEMDEFLSGTSCVTDCPEGQYGDEYTGTCRSCHPSCVTCAGPGDHECNSCLANFELELGFCRSSCTDSSYKDSNGNCQVCDKSCQTCTGTGPNECLSCNYYNFLAPTKACVTDCPVDYYPDYESNVCRRCDPSCKTCLDSGPGDCIECAPDTYMLLRNGQLCVEDCPEGYYDSEELGFRDCRQCSVECRDCDGSYLTCISCYDGTYLFQGRCFSTCPSGYIEDSETNHCIQHANICPLYCDQCDDWGDCTVCQGSYIVYFGECVNEDDMACLTNEYIVSFTNDGKATCESCDPSCGTCLGPDNTDCVTCASAQHHFQGSRCVQECEDTKFKDKDSNECFDCHPTCLNCDAGSPSDCTSCIEGMQLSDPVHGHGMCQFGCPEGHYLNSNGECLPCGSENCFTCYGPDESQCLSCNLGYLRTATGACLENCPQYTYEYLLEDAMEGNECRPCHQSCSSCNGPGPNSCTSCRDEMVLARGECGWDCEEGYYPDTEFQCQRCDKTCQTCIGIGSACTSCRIDQVLLGATCVDECGDGYFTVLENVPVCHECDDLCLSCTDYGPFDCTSCHPNHELDNGVCYNRCGSGRYYNRNEGVQDSATCGLCDANCAECFGPAPDQCISCKGLLRLEKIDRNNSRCIPCCNDVQDNEECCERCDDPDTHKCPKAYVHDAPAVVGGVKRYHISTIVFCVLLVIVLFFAVFGLLQARSHGKLCWSHKYAKVPSMNYNIKDKYVALGKPDDDYYEEDIYGDVSDDEEEDLEEPDTFQTVGITYQGQDRNGVVDHL
The following text describes a protein:
Function:
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Subcellular Localization:
Chromosome.
Sequence:
MARDARSSRLVKKQEISKKKPSLAQSKSCQVTKDAKKNSPVANCSANCKRLLAEKNEGKKKPQEHKPPLDSPCRFLRSSVTKAFAGSSWKNLKLSDSVLFHNQPPLSLTMNLRRKPFPHRLFETAAIMRAKRRTGLVKSSGKREKSELGTSHKIERKGVEKRAQGFKQDCNQNVESLSTKAGSALCDMEPDHPSECDGEAKKKAPTPENCLSVSSVDEPSVSTPKALQEDGKCKETVPTEQALEDLSTDVSYVALAEPVSSHLHLDSANALKVCERELGTLVKPGLENNFNSAPPSKEHSPPSFDSTLQLSSETNTKVPEKRPESPIEGHSIATCGSVLTPCEPDAIILITSELISKLHLDDTCALSEPHHEQDHEPASRREPDLLCISEQGDSPKDPGLGGKSSLPNDSEFKLGDKALDLSTSQKDYSGCDHIKKASTCKPVSNPVFTYGILEDLEQTLERIAAETLNLDSTTVPDLSLQPGKRTTDSVSVSSNIFNNTSQKSSKDANLKLPSESVGSPETRLVADGSCPNLQCPSLGLGSAEKDMISVQGTTKCGTNPSTTSELTSWGNPTSAFPVLFPSMQPVEKKKRRRCGVCEPCLRKTNCEECSCCMKRKTSHRICKKRKCEELKKPPPPLPPLMLPLKGDRENKPVNGCRADLMEYVAYSHIEKHKVKPTQSVLWENVQTSEKESMTGLETEKWTHNEKPLLSVHVNGDLCRTGTRDENSKHDDRNAKAVYSSNVLDEPKKLLAQTAKNGIKNIPYSPAECDVLQKKVDVGIRVNLANSCKESHSGASWSGSSALNNDSTLPTGTCGAFPKKKDHVLVQQPESSNIVQESENSLLQTISKDSQPEDLSLQSTFLSLIKNRNLTVEQVVAIEALTRLSEAPLKASSPGKTERVQCSEQQISHSLSSFKKDNSFSLTASALKAIKGASSQKDQQLFSHVPSQRRVLPKSLLYNGQGAISEFSSKSPGPSSLLRRLHCSAWDGKSFSALLPLGPCSKNASTVKQWRNKFEMLGKWEGKTVHGLNSKGNSVIRGNFHSQDEKEVATQLTQLAAIIESSKTSPDQKASLFGRIPSDMQSKHKQDQCLLQKKQSVFVRNNYSSLLVKQRQPTRKNDKLVPRAKRLKKKPQVISDQQNQLQQECQHSELQDIHKKPSKLHKLGRIVSQDSKLTVLGKKTTKAKVQKPRKRSALPTQQKTAALFLPKTQIIFHRPLPVSMQDKMKDHGLPSNNHLAVPHLDTKSCLSQGNENMHMLTENDKDSQVQQTMAQMHPLPQTFSQAGDMCKDNHAKFQQHAVEKQKDQNLQPIPINCGAVSPGDTIEALRNATCVDKIKFPTGKNLETENPHAKGNSGCYPMKNTLSSFLESPMKFLDTPTKNLIDTPSKKGQADFPSCDCVEQIIEKDEGPYYTHLGTGPSIAAVREIMENRYGAKGNAVRIEVVVYTGREGKSSQGCPIAKWVIRRSSDEEKLLCLVRQRAGHHCQTAVIVILILAWEGIPHLLADTLYKELTQSLRKYGCPTSRRCALNEDRTCACQGLDPETCGASFSFGCSWSMYYNGCKFARSKTPRKFRLLTDDHKQEENLENNLQTLATDVAPLYQKLAPDAFQNQVENEHFGPDCRLGVKSGRPFSGVTACIDFCAHAHKDTHNMHNGSTVVCTLTKEDNRTIGVIPNDEQLHVLPLYKISQTDEFGTEEGLEAKIKAGAIQVLTAFPREVRMLAEPRRATKKRKSENRKQTSAEKKHSIPVKGKSGISGNNNKASQKLGSKTNTLQAGTKMVTGDHLSAIKHNSDTTQNCSVLKQYPSSSPLKLDSLHSFSPLTHTAGGIMSLTNSQQDFSTPYGYLQCSSNKPQLTPKGKSFDNSPVSQLGNSCASLSLSNASENVVRNEIHSSQEHPVQQDGFIQTSNCASAIVDSQPNIELQKPTDSEEKAEEMWSDSEHNFLDNDIGGVAVAPSHGSILIECARRELHATTPIKKPNRNHPTRISLVFYQHKNLNEPKHGIALWEAKMAEKAKEKAAEKLGIENANLQANDRSGQQPNASREVFCEDSEFNQIPSRRALTVTHDKVITVSTYALTRVAGPYNHWA
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAARFAAFLKNAWAKELVLVALFTIQSLAVILPALSPYTNYTLRINRATPYKYPAPGFSNQSYSC
The following text describes a protein:
Function:
Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MLLIGLCAVLAVVAAAERPVVNKASGWSQFEAGRRYALQKPKQVTYDPLELDRFLFAIMDKLEDMPMPDDPKYEFVRDEHKQLHACEIPEDDDEAMEFSANPDAVMETVLRSFPDGKCAGRIFGEWYYEVCGNMEVKRAAFTVAYSRGKPKVTTFKAYESLGVLGRDRKVSRHLDSITEPRYVQQTYYDGAKCNLGGQPRRMQSVVTFECSHRFVAGYVHIAEVVEVHPCKYRLVVQSTDFCANDWLYGMVEENSVVRCRMFLHPERIRPLMSFLDKYHEETKEKLRRYAKYMDEPAMAASVRDQMSRPDARARIEEFAKANVRQFDRRDAEYGIQAERERNKRILDYVMSELTWASLNPDVPYTEEELRARREEETAGREDDERRLVTVENVLNYRRSDLMDEVEDDEEKEYYDIMGFTELLEIAEDIAGLRRDPYLNFYTAWLDYIRMLEVEEHVVVRPWLIPPNRKPFALGAFVLLEALIKSDQADEVRRLFEGLKEEEKPKEPVILYDGELDEDDLEEIARKFMQVYRAAKAGGSDTLLFELLDDEDFEY
The following text describes a protein:
Function:
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MDSREGEGPQCLKTLKDVRRSHKRDVLQTPVSRCRMGTGTVHPEQATACKGNQYLSGSHCCDLCPPGKKLVNDCTGITETECSPCGAGEFLDTWNRESRCHQHKYCDPNLGLQVQGTGTSTTDATCICHEGQHCSSDACESCILHSPCAPGLGVKQLATGVSDTVCEPCPVGFFSKVSSALEKCHPWTSCDTKGLVELQAGTNKTDAVCGFRNRMRALVVIPITMGVLFAVLLLSACIRKVAKEPENKALHRKVGWQDPVETVYPDDFPGPHSIAPVQETLHGCQPVTQEDGKESRISVQERQ
The following text describes a protein:
Function:
Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTESLVGERRAPQFRARLSGPAGPPSVRVGMAVVWLSVIVLLPLAAIVWQAAGGGWRAFWLAVSSHAAMESFRVTLTISTAVTVINLVFGLLIAWVLVRDDFAGKRIVDAIIDLPFALPTIVASLVMLALYGNNSPVGLHFQHTATGVGVALAFVTLPFVVRAVQPVLLEIDRETEEAAASLGANGAKIFTSVVLPSLTPALLSGAGLAFSRAIGEFGSVVLIGGAVPGKTEVSSQWIRTLIENDDRTGAAAISVVLLSISFIVLLILRVVGARAAKREEMAA
The following text describes a protein:
Function:
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.
Subcellular Localization:
Nucleus.
Sequence:
MAGAAAAVAAGAAAGAAAAAVSVAAPGRASAPPPPPPVYCVCRQPYDVNRFMIECDICKDWFHGSCVGVEEHHAVDIDLYHCPNCAVLHGSSLMKKRRNWHRHDYTEVDDGSKPVQAGTRTFVKELRSRVFPSADEIIVKMHGSQLTQRYLEKHGFEVPIMVPKLDDLGLRLPPPTFSVMDVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPNRPKVLNVISLEFSDTKMSELVEVPDIARKLSWVENYWPDDSVFPKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDDNLALYESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLETLKELREDGFQPQTYLVQGVKALHTALKLWMKKELVSEHAFEIPDNVRPGHLIKELSKVIRAVEEENGKPVKSQGIPTVCPVSRSSSEAASPHHSRRRMRRLRDHNVRTPSNLDILELHTREVLRRLEMCPWEEDILSSKLNGKFNKHLQPSSTVPEWRAKDNDLRLLLTNGRIIKDERQPFADQSLYAADSENEEDKRRTKKAKVKIEESSGIDGLENEASRKPLNRFLTSVKSELRNRPSEYSDISDSEDSGPDCTALKNNFTTEESESSGDEKKQEITSNFKEESNMMRNFLQKSQKPSRSEIPVKRECPTSTSTEEEAIQGMLSMAGLHYSTCLQRQIQSTDCDGDRRSLQDPSSCHSRNHEVRQLYRYDKPVECGYHVKTEDQDLRSSSWIKQFDTTSRFNLQDLRRGQKCIKKEVSSEISQKVQSRNSVDSSGSSPQSGKYTQSSSLLSGVCQMSNGTVSPEGPVGETSFSVPLHPTKRPASNPPPISNQATKGKRPKKGMATAKQRLGKILKLNRNGHARFFV
The following text describes a protein:
Function:
Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity).
Subcellular Localization:
Cell junction, adherens junction. Cytoplasm, cytoskeleton. Apical cell membrane; Peripheral membrane protein. Note=Colocalizes with F-actin in stress fibers and adherens junctions.
Domain:
The ASD1 domain mediates F-actin binding; The ASD2 domain mediates the interaction with ROCK1 and is required for apical constriction induction.
Sequence:
MMRTTEDFHKPSATLNSNTATKGRYIYLEAFLEGGAPWGFTLKGGLEHGEPLIISKVEEGGKADTLSSKLQAGDEVVHINEVTLSSSRKEAVSLVKGSYKTLRLVVRRDVCTDPGHADTGASNFVSPEHLTSGPQHRKAAWSGGVKLRLKHRRSEPAGRPHSWHTTKSGEKQPDASMMQISQGMIGPPWHQSYHSSSSTSDLSNYDHAYLRRSPDQCSSQGSMESLEPSGAYPPCHLSPAKSTGSIDQLSHFHNKRDSAYSSFSTSSSILEYPHPGISGRERSGSMDNTSARGGLLEGMRQADIRYVKTVYDTRRGVSAEYEVNSSALLLQGREARASANGQGYDKWSNIPRGKGVPPPSWSQQCPSSLETATDNLPPKVGAPLPPARSDSYAAFRHRERPSSWSSLDQKRLCRPQANSLGSLKSPFIEEQLHTVLEKSPENSPPVKPKHNYTQKAQPGQPLLPTSIYPVPSLEPHFAQVPQPSVSSNGMLYPALAKESGYIAPQGACNKMATIDENGNQNGSGRPGFAFCQPLEHDLLSPVEKKPEATAKYVPSKVHFCSVPENEEDASLKRHLTPPQGNSPHSNERKSTHSNKPSSHPHSLKCPQAQAWQAGEDKRSSRLSEPWEGDFQEDHNANLWRRLEREGLGQSLSGNFGKTKSAFSSLQNIPESLRRHSSLELGRGTQEGYPGGRPTCAVNTKAEDPGRKAAPDLGSHLDRQVSYPRPEGRTGASASFNSTDPSPEEPPAPSHPHTSSLGRRGPGPGSASALQGFQYGKPHCSVLEKVSKFEQREQGSQRPSVGGSGFGHNYRPHRTVSTSSTSGNDFEETKAHIRFSESAEPLGNGEQHFKNGELKLEEASRQPCGQQLSGGASDSGRGPQRPDARLLRSQSTFQLSSEPEREPEWRDRPGSPESPLLDAPFSRAYRNSIKDAQSRVLGATSFRRRDLELGAPVASRSWRPRPSSAHVGLRSPEASASASPHTPRERHSVTPAEGDLARPVPPAARRGARRRLTPEQKKRSYSEPEKMNEVGIVEEAEPAPLGPQRNGMRFPESSVADRRRLFERDGKACSTLSLSGPELKQFQQSALADYIQRKTGKRPTSAAGCSLQEPGPLRERAQSAYLQPGPAALEGSGLASASSLSSLREPSLQPRREATLLPATVAETQQAPRDRSSSFAGGRRLGERRRGDLLSGANGGTRGTQRGDETPREPSSWGARAGKSMSAEDLLERSDVLAGPVHVRSRSSPATADKRQDVLLGQDSGFGLVKDPCYLAGPGSRSLSCSERGQEEMLPLFHHLTPRWGGSGCKAIGDSSVPSECPGTLDHQRQASRTPCPRPPLAGTQGLVTDTRAAPLTPIGTPLPSAIPSGYCSQDGQTGRQPLPPYTPAMMHRSNGHTLTQPPGPRGCEGDGPEHGVEEGTRKRVSLPQWPPPSRAKWAHAAREDSLPEESSAPDFANLKHYQKQQSLPSLCSTSDPDTPLGAPSTPGRISLRISESVLRDSPPPHEDYEDEVFVRDPHPKATSSPTFEPLPPPPPPPPSQETPVYSMDDFPPPPPHTVCEAQLDSEDPEGPRPSFNKLSKVTIARERHMPGAAHVVGSQTLASRLQTSIKGSEAESTPPSFMSVHAQLAGSLGGQPAPIQTQSLSHDPVSGTQGLEKKVSPDPQKSSEDIRTEALAKEIVHQDKSLADILDPDSRLKTTMDLMEGLFPRDVNLLKENSVKRKAIQRTVSSSGCEGKRNEDKEAVSMLVNCPAYYSVSAPKAELLNKIKEMPAEVNEEEEQADVNEKKAELIGSLTHKLETLQEAKGSLLTDIKLNNALGEEVEALISELCKPNEFDKYRMFIGDLDKVVNLLLSLSGRLARVENVLSGLGEDASNEERSSLYEKRKILAGQHEDARELKENLDRRERVVLGILANYLSEEQLQDYQHFVKMKSTLLIEQRKLDDKIKLGQEQVKCLLESLPSDFIPKAGALALPPNLTSEPIPAGGCTFSGIFPTLTSPL
The following text describes a protein:
Function:
Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: The curated signal sequence though non-canonical is consistent with the proven topology of the mouse ortholog; MISCELLANEOUS: [Isoform 1]: Has a predicted canonical N-terminal signal sequence that is consistent with the proven topology of the mouse ortholog. Alternative initiation is supported by ribosome profiling data.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane. Cytoplasmic vesicle membrane. Cytoplasm, perinuclear region. Cell junction, focal adhesion. Secreted. Cell projection, neuron projection. Cell junction. Note=In addition to its location at the cell membrane, colocalizes with FGFR1 in punctate perinuclear cytoplasmic vesicles. Detected along neurites and at contacts between neurite termini and other cells. Proteolytic cleavage gives rise to a shedded ectodomain.
Sequence:
MVVAHPTATATTTPTATVTATVVMTTATMDLRDWLFLCYGLIAFLTEVIDSTTCPSVCRCDNGFIYCNDRGLTSIPADIPDDATTLYLQNNQINNAGIPQDLKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGMAIKDITSEMDECFETGPQGGVANAAAKTTASNHASATTPQGSLFTLKAKRPGLRLPDSNIDYPMATGDGAKTLAIHVKALTADSIRITWKATLPASSFRLSWLRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYIICMVTMETSNAYVADETPVCAKAETADSYGPTTTLNQEQNAGPMASLPLAGIIGGAVALVFLFLVLGAICWYVHQAGELLTRERAYNRGSRKKDDYMESGTKKDNSILEIRGPGLQMLPINPYRAKEEYVVHTIFPSNGSSLCKATHTIGYGTTRGYRDGGIPDIDYSYT
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 2100 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MFGPFKLTSPVAGGLLWKIPWRMSTHQKTRQRERLRNVDQVIKQLTLGLHVQRCQDKGLTYQEAMESKKKYKPRSKSLRLLNKPSVFPKENQMSSKDKYWTFDKKAVGYRKGIHKVPKWTKISIRKAPKFF