The following text describes a protein:
Function:
[Helper component proteinase]: Cysteine protease that cleaves a Gly-Gly dipeptide at its own C-terminus (By similarity). Required for aphid transmission and also has proteolytic activity (By similarity). Interacts with virions and aphid stylets (By similarity). Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity). May have RNA-binding activity (By similarity); [Cytoplasmic inclusion protein]: Has helicase activity. It may be involved in replication; [6 kDa protein 1]: Indispensable for virus replication (By similarity). Reduces the abundance of host transcripts related to jasmonic acid biosynthesis therefore altering the host defenses. In order to increase its own stability, decreases host protein degradation pathways; [6 kDa protein 2]: Responsible for the formation of peripheral motile host endoplasmic reticulum (ER)-derived viral vesicles called 'viral factories', seat of the viral RNA (vRNA) replication and carrying vRNA to plasmodesmata for delivery into adjacent non-infected cells; this process relies on host Sec24a-binding; [Viral genome-linked protein]: Mediates the cap-independent, EIF4E-dependent translation of viral genomic RNAs (By similarity). Binds to the cap-binding site of host EIF4E and thus interferes with the host EIF4E-dependent mRNA export and translation (By similarity). VPg-RNA directly binds EIF4E and is a template for transcription (By similarity). Also forms trimeric complexes with EIF4E-EIF4G, which are templates for translation (By similarity); [Nuclear inclusion protein A]: Has RNA-binding and proteolytic activities; [Nuclear inclusion protein B]: RNA-dependent RNA polymerase that ensures transcription and replication of viral RNA (vRNA); [Capsid protein]: Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
Miscellaneous:
MISCELLANEOUS: [Isoform Genome polyprotein]: Produced by conventional translation.
Subcellular Localization:
[6 kDa protein 1]: Host cytoplasm. Host nucleus. Host cytoplasmic vesicle. Note=Probably colocalizes with 6K2-induced vesicles associated with host chloroplasts; [6 kDa protein 2]: Host cytoplasmic vesicle. Host membrane. Note=6K-induced vesicles associate with host chloroplasts; [Viral genome-linked protein]: Host nucleus. Note=Binds to host plant eIF4E proteins in the host nucleus; [Capsid protein]: Virion.
Domain:
[Helper component proteinase]: The N-terminus is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus.
Sequence:
MAAVTFASAITNAITSKPALTGMVQFGSFPPMPLRSTTVTTVATSVAQPKLYTVQFGSLDPVVVKSGAGSLAKATRQQPNVEIDVSLSEAAALEVAKPRSNAVLRMHEEANKERALFLDWEASLKRSSYGIAEDEKVVMTTHGVSKIVPRSSRAMKLKRARERRRAQQPIILKWEPKLSGISIGGGLSASVIEAEEVRTKWPLHKTPSMKKRTVHRICKMNDQGVDMLTRSLVKIFKTKSANIEYIGKKSIKVDFIRKERTKFARIQVAHLLGKRAQRDLLTGMEENHFIDILSKYSGNKTTINPGVVCAGWSGIVVGNGILTQKRSRSPSEAFVIRGEHEGKLYDARIKVTRTMSHKIVHFSAAGANFWKGFDRCFLAYRSDNREHTCYSGLDVTECGEVAALMCLAMFPCGKITCPDCVTDSELSQGQASGPSMKHRLTQLRDVIKSSYPRFKHAVQILDRYEQSLSSANENYQDFAEIQSISDGVEKAAFPHVNKLNAILIKGATVTGEEFSQATKHLLEIARYLKNRTENIEKGSLKSFRNKISQKAHINPTLMCDNQLDRNGNFIWGERGYHAKRFFSNYFEIIDPKKGYTQYETRAVPNGSRKLAIGKLIVPTNFEVLREQMKGEPVEPYPVTVECVSKLQGDFVHACCCVTTESGDPVLSEIKMPTKHHLVIGNSGDPKYIDLPEIEENKMYIAKEGYCYINIFLAMLVNVKESQAKEFTKVVRDKLVGELGKWPTLLDVATACYFLKVFYPDVANAELPRMLVDHKTKIIHVVDSYGSLSTGYHVLKTNTVEQLIKFTRCNLESSLKHYRVGGTEWEDTHGSSNIDNPQWCIKRLIKGVYKPKQLKEDMLANPFLPLYALLSPGVILAFYNSGSLEYLMNHYIRVDSNVAVLLVVLKSLAKKVSTSQSVLAQLQIIERSLPELIEAKANVNGPDDAATRACNRFMGMLLHMAEPNWELADGGYTILRDHSISILEKSYLQILDEAWNELSWSERCAIRYYSSKQAIFTQKDLPMKSEADLGGRYSVSVMSSYERSKQCMKSVHSSIGNRLRSSMSWTSSKVSNSVCRTINYLVPDVFKFMNVLVCISLLIKMTAEANHIVTTQRRLKLDVEETERRKIEWELAFHHAILTQSAGQHPTIDEFRAYIADKAPHLSEHIEPEEKAVVHQAKRQSEQELERIIAFVALVLMMFDAERSDCVTKILNKLKGLVATVEPTVYHQTLNDIEDDLSERNLFVDFELSSDGDMLQQLPAEKTFASWWSHQLSRGFTIPHYRTEGKFMTFTRATATEVAGKIAHESDKDILLMGAVGSGKSTGLPYHLSRKGNVLLLEPTRPLAENVHKQLSQAPFHQNTTLRMRGLTAFGSAPISVMTSGFALNYFANNRMRIEEFDFVIFDECHVHDANAMAMRCLLHECDYSGKIIKVSATPPGREVEFSTQYPVSISTEDTLSFQDFVNAQGSGSNCDVISKGDNILVYVASYNEVDALSKLLIERDFKVTKVDGRTMKVGNIEITTSGTPSKKHFIVATNIIENGVTLDIDVVADFGTKVLPYLDTDSRMLSTTKTSINYGERIQRLGRVGRHKPGHALRIGHTEKGLSEVPSCIATEAALKCFTYGLPVITNNVSTSILGNVTVKQARTMSVFEITPFYTSQVVRYDGSMHPQVHALLKRFKLRDSEIVLNKLAIPHRGVNAWLTASEYARLGANVEDRRDVRIPFMCRDIPEKLHLDMWDVIVKFKGDAGFGRLSSASASKVAYTLQTDVNSIQRTVTIIDTLIAEERRKQEYFKTVTSNCVSSSNFSLQSITNAIKSRMMKDHTCENISVLEGAKSQLLEFRNLNADHSFATKTDGISRHFMSEYGALEAVHHQNTSDMSKFLKLKGKWNKTLITRDVLVLCGVLGGGLWMVIQHLRSKMSEPVTHEAKGKRQRQKLKFRNARDNKMGREVYGDDDTIEHFFGDAYTKKGKSKGRTRGIGHKNRKFINMYGFDPEDFSAVRFVDPLTGATLDDNPLTDITLVQEHFGNIRMDLLGEDELDSNEIRVNKTIQAYYMNNKTGKALKVDLTPHIPLKVCDLHATIAGFPERENELRQTGKAQPINIDEVPRANNELVPVDHESNSMFRGLRDYNPISNNICHLTNVSDGASNSLYGVGFGPLILTNRHLFERNNGELVIKSRHGEFVIKNTTQLHLLPIPDRDLLLIRLPKDVPPFPQKLGFRQPEKGERICMVGSNFQTKSITSIVSETSTIMPVENSQFWKHWISTKDGQCGSPMVSTKDGKILGLHSLANFQNSINYFAAFPDDFAEKYLHTIEAHEWVKHWKYNTSAISWGSLNIQASQPSGLFKVSKLISDLDSTAVYAQTQQNRWMFEQLNGNLKAIAHCPSQLVTKHTVKGKCQMFDLYLKLHDEAREYFQPMLGQYQKSKLNREAYAKDLLKYATPIEAGNIDCDLFEKTVEIVVSDLRGYGFETCNYVTDENDIFEALNMKSAVGALYKGKKKDYFAEFTPEMKEEILKQSCERLFLGKMGVWNGSLKAELRPLEKVEANKTRTFTAAPLDTLLGGKVCVDDFNNQFYDHNLRAPWSVGMTKFYCGWDRLLESLPDGWVYCDADGSQFDSSLSPYLINAVLNIRLGFMEEWDIGEVMLRNLYTEIVYTPISTPDGTLVKKFKGNNSGQPSTVVDNTLMVILAVNYSLKKSGIPSELRDSIIRFFVNGDDLLLSVHPEYEYILDTMADNFRELGLKYTFDSRTREKGDLWFMSHQGHKREGIWIPKLEPERIVSILEWDRSKEPCHRLEAICAAMIESWGYDKLTHEIRKFYAWMIEQAPFSSLAQEGKAPYIAETALRKLYLDKEPAQEDLTHYLQAIFEDYEDGAEACVYHQAGETLDAGLTDEQKQAEKEKKEREKAEKERERQKQLALKKGKDVAQEEGKRDKEVNAGTSGTFSVPRLKSLTSKMRVPRYEKRVALNLDHLILYTPEQTDLSNTRSTRKQFDTWFEGVMADYELTEDKMQIILNGLMVWCIENGTSPNINGMWVMMDGDDQVEFPIKPLIDHAKPTFRQIMAHFSDVAEAYIEKRNQDRPYMPRYGLQRNLTDMSLARYAFDFYEMTSRTPIRAREAHIQMKAAALRGANNNLFGLDGNVGTTVENTERHTTEDVNRNMHNLLGVQGL