lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. Although it has succinate semialdehyde dehydrogenase activity, is likely to act physiologically on a different aldehyde(s). NAD(+) can substitute for NADP(+), but enzymatic activity is three times reduced.
Sequence:
MPAPSAEVFDRLRNLAAIKDVAARPTRTIDEVFTGKPLTTIPVGTAADVEAAFAEARAAQTDWAKRPVIERAAVIRRYRDLVIENREFLMDLLQAEAGKARWAAQEEIVDLIANANYYARVCVDLLKPRKAQPLLPGIGKTTVCYQPKGVVGVISPWNYPMTLTVSDSVPALVAGNAVVLKPDSQTPYCALACAELLYRAGLPRALYAIVPGPGSVVGTAITDNCDYLMFTGSSATGSRLAEHAGRRLIGFSAELGGKNPMIVARGANLDKVAKAATRACFSNAGQLCISIERIYVEKDIAEEFTRKFGDAVRNMKLGTAYDFSVDMGSLISEAQLKTVSGHVDDATAKGAKVIAGGKARPDIGPLFYEPTVLTNVAPEMECAANETFGPVVSIYPVADVDEAVEKANDTDYGLNASVWAGSTAEGQRIAARLRSGTVNVDEGYAFAWGSLSAPMGGMGLSGVGRRHGPEGLLKYTESQTIATARVFNLDPPFGIPATVWQKSLLPIVRTVMKLPGRR
The following text describes a protein:
Function:
GTPase-activating protein for the ADP ribosylation factor family.
Subcellular Localization:
Cytoplasm.
Sequence:
MGNVSSRPDDGAPLYLRDQNRLTISSLSITNQRRRTLLNIVPNGFPATRVSAIRDLGDNSVVEYVQDPDTLPGAAPNLLLKVNNDEELTFHFTFIIRQSQGFLSATNGAKDVVGLMDTVINGLTYVSASTAREVENLVTREFHADPNLHKNANVQLVGDYSTGGSQSVSFEWSWKWRPPKPTEDRGGGWRNNCSFLEYDQRAHRLNTLASFSFWVSSKATIALSQSSANKVLDPQPLSMPGSPSPPFHLVPPPKLRLPSSQSLDSRVSGQELSYSFEDAPPSPNPLSLDFIVPQSHFTDAPKVDVSCQRPGEDMSATEDGPLFRATMKALEQKTGNMRTRMKKVLRKAEAAQIAQMQCNDAIGGFMEALREASNSNANAVQPALDHYFDKIAREILQYEKQNAINLEKVIIEPLAKLYTLDIKQAESKKRDFEEESKDYYAYVSRYLGQRQDSLKQKKRVESDTKYQTKRRNFELKRFDYSSFMQDLHGGRKEQEVLSHLTKYADAQTRSYLAAAKKVEQMLPQLEALSAEVQDADKEFQYQRTEREEKRRNLEKSTVTYVEPETVPVETVAPGTSSSGNGAYTSDTELNRADSTGHQLRIVPTNSTIATVTNGGATEFSRTPGSLSSVHGGPVGSPAANPRFRGIRDLEEKDHSQITASEKLGTQRKEGLLWALSRPGSHVDPRGLNKQAWHKFWIVLDAGKLSEYSNWKQRLDLHMEPIDLRMASVREARDAERRFCFEVITPQYKRVYQATSEDDMKNWISAINNALQSAVEGRGMKDYPALTPQPEAHSMRRDIGSILTGKSSSLNQGHSSNHNNTSNTNNVFRRTTVGARPAYGRSNSSSFDESPDKLLQLLRETDQGNCWCADCGSGIKTEWVSINLAIILCIECSGIHRSLGTHISKVRSLTLDINSFTTDIVELLLLVGNRVSNMIWEARLDLATKPTPQATREQRLKFITAKYVDRAFVEPISSTLSRYGTADETLLAAIKKNDVQQVIYALALKANPNVTDRSRGTHSVFLALAAADPASPAQVASPTRVEHAAKIVPFPIAEMLVQHGAEIPTVLPAFPLSRSATLYIEQKTHRGGSTNDTLAALPTTMTQQDKLKEREARLQKRVSAGGRLAKAPIQERS
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MVLAELGGQIASALQKMSNVTIIDEKALNECLKEITHALLHSDVSFPLVREMQNNIKKIVNLEELAAGHNKRRIIEQAIFSELCKMLDPGKPAFKVRSFGLLMFRCWACAFDQLKQNATKSRIPFYGSYTESDPVKIAVEGVDTFKKENCDLIIVDTSGRHKQEATLFEEMCQVAEATVCSVVLEALFFLSGYCRL
The following text describes a protein:
Function:
Possesses E3 ubiquitin-protein ligase in vitro. May be involved in cell death signaling.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MQTGFSNSRMNSFISSVLVLHFNKQEIKFEPSVWCEAIDIHNTFSAGEIITGDIICFQKILKPPDIPKYPSVASFLQHVCDRKTYEEVRKVHILEEEIVTLKHQADTYLVQKEKAVTAYDQLKHERDNAVQQVNELRDQSTHIILDFSRKDMEQATEHFKNAREVGDTEYGHTYKGMIHNMKVLIKLSSSQKLFQQEVSILRQWRHPNIITFIGVCSEVSALVYEWLPNGNLEDRIICTNNSAPLSWYNRTQIIGEICCALLFLHSNKSTALVHGDLRPCNILIDANYRSKICNFGMSNLFLQLGTFPPNLTARLPYMDPEFNTTGELTTLSDVYSLGVIILRLLTGMPPLTLSEKVAEALGSDSLHLLIDKSAGDWPYIEAKQLALIGLSCTGMTRKKRPDLLNEVWIVIEPLTRKPPAATWPYLQSASGDSSVPAAFICPISMEIMKDPQVASDGFTYEAEAIRCWFDRGISRSPMTNLALPNLNLVPNRVLRSFIHGYLQQQQPNPAYQQQLSET
The following text describes a protein:
Function:
Regulates DNA damage response and cell proliferation in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MAQEVSEYLSQNPRVAAWVETLRCEGETDKHWRHRREFLLRNAGDLVPATDETADAESGARTRQLQQLVSFSMAWANHVFLGCRYPQKVMDKILSMAEGIKVTDAPIHTTRDELVAKVKKRGISSSNEGVEEPSKKRAVEGKNNSSVERDHGKKSAKTDRSAAQQENSSPSRGSSTKSESGGTSARSSSSGSHQDSATSEGDRSVCSQSSSNSSQVTAGSGKALESEAPHKRGSASFVSSLLKSSMNSHMTQSTDNRQQSGSPKKGALEGSSGSASQSSSEIEVPLLGSSGSAEVELPLLSCKSSSETASSGLTSKSSSEANISSSVSKNSSSSGSSLLTPQSSSTNPSLLTSKSTAQVAASLLATKSGASLGSVSQLAAKSGSQSSTSQLPSKSTSQASESSVKFACRKLTNEDIKQKQPFFNRLYKTVAWKLVAVGGFSPTVNHGELLNAAIEALKATLDVFFVPLKELADLPQNKSSQESIVCELRCKSVYLGTGCGKSKENAKAVASREALKLFLKKKVVVKICKRKYRGSEIEDLVLLDEEARPVNLPPALKHPQELL
The following text describes a protein:
Function:
May play a role in the structure and strength of both muscle and bone.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MQWNVPRSVFRLAHRTCMEPHKASLFGHRQNIKGPLLLYKAESRVVLVQGRQKQWLHLSAVQCVAKERKPFTAHPPQLGVLHHKQWEQDILSKRVMSSKATSPGTSSEKKEEPDPLQDKSINLYQRFKKTFRQYGKVLIPVHLITSGVWFGTFYYAAIKGVNVVPFLELIGLPDSIVNILKNSQSGNALTAYALFKIATPARYTVTLGGTSFTVKYLRSRGYMSTPPPVKEYLQDRMEETKELLTEKMEETKDRLTEKLQETKEKVSFKKKVE
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
Sequence:
MNTKEPHKRLVQGKVISKFAEKSAVILVERKVVHEKYRKIVKKFKKYTIHDENNQVKVGDFVSAIECRPLSKTKSFTLKEILVVGV
The following text describes a protein:
Function:
A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA, residue 'Val-148' of RseA may be required for this. This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA. Can also cleave sequences in transmembrane regions of other proteins (such as LacY) as well as liberated signal peptides of beta-lactamase, OmpF, LivK, SecM, PhoA, LivJ, OmpC, Lpp and TorA, probably within the membrane. Cleaves FecR within its transmembrane region to release an N-terminal cytoplasmic fragment which binds to sigma factor FecI, allowing it to activate transcription of the fecABCDE operon which mediates ferric citrate transport.
Miscellaneous:
MISCELLANEOUS: Regulated intramembrane proteolysis (RIP) occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. A membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, this enzyme), while cytoplasmic proteases finish degrading the regulatory protein, liberating the effector protein.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The 2 circularly premutated PDZ domains act to negatively regulate protease action on intact RseA; mutations in PDZ 1 (PDZ-N) have a more deleterious effect than similar mutations in PDZ 2 (PDZ-C). A 31 residue insertion in PDZ-C (between Val-261 and Met-262) domain inhibits protease activity, whereas deletion of residues 203-279 alleviates the PDZ-inhibition, allowing cleavage of intact RseA.
Sequence:
MLSFLWDLASFIVALGVLITVHEFGHFWVARRCGVRVERFSIGFGKALWRRTDKLGTEYVIALIPLGGYVKMLDERAEPVVPELRHHAFNNKSVGQRAAIIAAGPVANFIFAIFAYWLVFIIGVPGVRPVVGEIAANSIAAEAQIAPGTELKAVDGIETPDWDAVRLQLVDKIGDESTTITVAPFGSDQRRDVKLDLRHWAFEPDKEDPVSSLGIRPRGPQIEPVLENVQPNSAASKAGLQAGDRIVKVDGQPLTQWVTFVMLVRDNPGKSLALEIERQGSPLSLTLIPESKPGNGKAIGFVGIEPKVIPLPDEYKVVRQYGPFNAIVEATDKTWQLMKLTVSMLGKLITGDVKLNNLSGPISIAKGAGMTAELGVVYYLPFLALISVNLGIINLFPLPVLDGGHLLFLAIEKIKGGPVSERVQDFCYRIGSILLVLLMGLALFNDFSRL
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MPPRQPAARGPVVSARQHRDDAMDQGDDLEASPVRGSPQQQEQAEEAGVERGAGVPDKPARQPRKKDPKLDLDLLEANGGFNDVWHTIAPAFKASFQGEGHEVADLRRLLELYQRWQMRFYPHCDFDTFVTKLEKSGRSRAIKSKMHSMRQNLLGLIFPDEEPAAATAGAPADLQPAAGANTNAAAATAFQTPAPGAAPRAAGAPATGAAGAAAAGGDDLDDELVAMQREAEWEAALAAMDALEATKAAGGTTQPAAAAAAPAAADVDVDMDELMALAEEQHHQHQQQAAAAVAAARPEEDALDAELYALAMEHEAAAPGPQQQQQQQQLAEGPQGAATTAAGVSAAADAEAEAEADLDAELMALAQMDVAPPAGAAAAVELQAAGGADAEGGAAAMEVDAAAGAAAAGASQEDAELDAELLALANAEFSLPAAAAVTMTVTASVVCASNAPEASVVVGGSAAAAGGLEGSEAASGVADCAGGSQVLGTAGGSVAQPGLGLAGDSQLEQEGEGSGSQAAGVVLGILMTQTQQDI
The following text describes a protein:
Function:
Chaperone that binds to and unwinds RNA and both single-stranded DNA and double-stranded DNA (ssDNA and dsDNA DNA) (By similarity). Regulates the flowering transition and flower and seed development, particularly at late stages of embryo development, through regulation of gene expression (including MEA, FIS2, AP1, CAL, AG and SHP2).
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MSGGGDVNMSGGDRRKGTVKWFDTQKGFGFITPSDGGDDLFVHQSSIRSEGFRSLAAEESVEFDVEVDNSGRPKAIEVSGPDGAPVQGNSGGGGSSGGRGGFGGGGGRGGGRGGGSYGGGYGGRGSGGRGGGGGDNSCFKCGEPGHMARECSQGGGGYSGGGGGGRYGSGGGGGGGGGGLSCYSCGESGHFARDCTSGGAR
The following text describes a protein:
Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus. Nucleus, nucleoplasm.
Sequence:
MSIISEHGFRMDGRRPAQIRNINTRLGLNRNAEGSCYLEHGNTKVLCAVYGPYESKASKRLEDRCAIVCQYSTTTFSGLERKNRPRGDRKSTEISRLLEKAFESVILTESFPRSQIDIFCEVIQGDGSNLAACVNATSLALADAGIPMKGIASAATCGIVETKPIVDLTSREETDLLPRVTLATICGRDEVILVELQNRLHIDHLSVVMDAAKATCADVYECLAVVAQQHLKACAPILGN
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTFQFDLMYKTMYVGVGLAFIVFFPLPRIIRKPLVRGLEKIFNNSIFSKVLYSILSWTLFLFVSAVSENLDLGKELVGQKAQRDSYASGTSQYELEKTVNQTRMKMFYSQRNIYLTLFNLIIFGAIFTYLKSLVKYDEQLDKEDKLKKQINVPKGAVGNVKQ
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MSHSIESLFKSPQNNCKVFQNGHIILNEFKNENFENAVRDWVMRNCSSFNQTASNQSTSSTANNQSTLTTANNQSTKADAINNNQPMENHCASSLKQSCDELSTNNDCSNNKDNSACNDFDPTSLNQPALKQLISLLVECLLHVNNNLSGCNYDYDEKNVVGVNLDEVDSNYGDDNNDDGENRECCVNQKNDINIKNCCSVGTNNDQNISKDVLVYDTENNDANQDGGAEVLICRESKFFKEPCCESKDGSCCGLPCDCVLSCVLSCQKLDSNLTLKHIHNSYKVVCDYFNTHHDSRQKCSIHGPYDAGWLHNCPLEEIKTEILDGLLVLKDNEEFHKKKTLKSGPKPGHQIRPEPDSAGFEKKPDFGRGRTSIKKFLTARSAKDCSIIVSLSSSKSKKHLVKSCDNIFILGDSKEIIANVSIIDLDMKDFHKIPSYLEEDQTIVNCYESQQCF
The following text describes a protein:
Function:
Involved in the biosynthesis of phenazine natural products including myxin, an N(5),N(10)-dioxide phenazine antiobiotic, which has antimicrobial activity. Catalyzes the aromatic N-oxidations of phenazines, such as 1,6-dihydroxyphenazine (DHP), 1,6-dihydroxyphenazine N(5)-oxide (DHPO) and 1-hydroxy-6-methoxyphenazine to produce DHPO, iodinin (1,6-dihydroxyphenazine N(5),N(10)-dioxide) and 1-hydroxy-6-methoxyphenazine N(10)-oxide, respectively. Also catalyzes the N-oxidation of 8-hydroxyquinoline, but not 6-hydroxyquinoline (6-HQ), quinoline, quinoxaline, quinine and 2-phenylpyridine.
Sequence:
MIDNDKTHFDAIVIGTGFAGIYMLHKLRNELGLKVRAFDKASGVGGTWYWNKYPGARADTESFVYRYSFDKETSEGWDWRNRYVDQPEMLGYLQAVVDRHGLAKDIQLKTGIDSAVFDEIHHIWTLTTSTGELFTARYLVNAVGVLSKIVIPQIPGRDKFQGQIVHTGAWPADLSLEGKRVGVIGTGSTGVQFICAASKLARHLTVFQRSAQFCVPAGSRQVSEAYVAEYKNNFEQIWDGIRNSRIACGFEESGVSAMSVSEEERQKVFEHHWEIGNGFRFMFGTFSDIAVDPAANQAASDFIRAKIRQIVKDPETARKLCPTDLYAKRPVCTNDYYETYNLPNVSLVSLPENPIKELTANGVLTEDGVEHKLDLLVFATGFETVEGSYNQMEIRGRGGETLQHHWKDAPSSYLGVATAGFPNMFMVLGPNSAFSNLPPSIESQVEWIGELIGWAEGESTPVIETTREAEEAWTATCKEIAAYTLFPKVKSWIFGENIDGRSSRVLFYFGGLAGYRAKLREVADADYEGFILHSDPSSMVA
The following text describes a protein:
Function:
Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The N-terminal portion of EID2 is required for nuclear localization.
Sequence:
MSELPADQGVPPAGAANDNGDVRQAEVGGRRREPAPAQPVAARDRPMAAAVEGSMASPVEGPVPEAREGPMAASREGLGAAAREARMAEVARLLAEPAEEEGPEGRPRSRPGNGPGLAALPYLRLRHPLGVLGINYQQFLRHYLEHYPIAPGRIQELEGRRRRFVEACRAREAAFDAEYQRNPQRMDFDILTFSITLTASEIINPLIEELGCDKFISRE
The following text describes a protein:
Function:
Involved in the protection against polyamine toxicity by regulating their concentration. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to the primary amino groups of spermidine to yield N(1)- and N(8)-acetylspermidine. It can also use spermine.
Subcellular Localization:
Cytoplasm.
Sequence:
MVQYLKKIKLRPLERDDLTFIHQLDNNASVMRYWFEEPYEAFVELTDLYDKHIHDQSERRFIIEYSSYKVGLVELVEINYIHRRAEFQIIIDPNYQGKGYAVSATKLAINYAFSILNLYKLYLVVDESNEKAIHIYLKLGFIIEGRLIHEFFSNGKYRDVIRMCVFQNNFNNKY
The following text describes a protein:
Function:
Probable beta-1,4-xylosyltransferase involved in xylan biosynthesis in cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MSRRNAGAMQREGSVKDWEEFDPSPSPKLAYSQSYVAMRGLLTSVASLDLVLMSSSLKSAWAAISSHKHARSLERSRSKGMSLKRAMLQLLVCFMVGIFIGFTPPFSVDLPGKIASENGRLPFDGDAIDRRQMVERQGTKLEPFVAEAESEASSEPQVEEGPPVPAMLDDEADFVEASPIVHSVNDSGIVVRKHLIIITTTSVRPHQAYYLNRLAHVLKDVPPPLLWIVAEWPYQSRETAEILRSSGIMYRHLICNRNTTNIRKIVVCQKNNAIFHIKKHRLDGIVHFADEERAYSADLFEEMRKIRRFGTWPVAIHVGTKYRVVLEGPVCKGNQVTGWHTNQRRGVSRRFPIGFSGFAFNSTILWDPQRWNSPTLESIIVHSGGRGGLQESRFIEKLVEDESQMEGLGDNCTRVMVWNFELEPPQVNYPIGWLLQRNLDAVVPIT
The following text describes a protein:
Function:
Could be a digestive enzyme.
Subcellular Localization:
Secreted.
Sequence:
MRCSLRMQLLLLLGLCVFISRIQGQLIGGEEDEEDEEEEEEEEESVEDETPEDRLQRKNIKQDSTLSVDKLIAKYGYESEVHHVTTEDGYILTMHRIRKQGAPPFLLQHGLVDSSAGFVVMGPNVSLAYLLADHNYDVWLGNARGNRYSRNHTTLDPDESKFWDFSWHEIGMYDLPAMIDHVLKVTGFPKLHYAGHSQGCTSFFVMCSMRPAYNDKVVSMQALAPAVYAKETEDHPYIRAISLYFNSLVGSSIREMFNGEFRFLCRMTEETERLCIEAVFGIVGRNWNEFNRKMFPVILGHYPAGVAAKQVKHFIQIIKSGRFAPYSYSSNKNMQLYRDHLPPRYNLSLVTVPTFVYYSTNDLLCHPKDVESMCDDLGNVTGKYLVPQKEFNHMDFLWAIDVRKMLYRRMLQVLGKVPEGSPEEANRSRREIRGKFIRS
The following text describes a protein:
Function:
3beta-hydroxysteroid-dehydrogenase/decarboxylase involved in sterol synthesis. Catalyzes the formation of 3-oxosteroids from 3beta-hydroxysteroids-4alpha-carboxylate. Involved in the regulation of inflorescence internodes and leaves growth, probably by affecting auxin transporter activity possibly by altering sterol composition in the membranes.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The RETICULON domain is partial in comparison with the other paralogs.
Sequence:
MVMEVTETERWCVVTGGRGFAARHLVEMLVRYQMFHVRIADLAPAIVLNPHEETGILGEAIRSGRVQYVSADLRNKTQVVKGFQGAEVVFHMAAPDSSINNHQLQYSVNVQGTTNVIDACIEVGVKRLIYTSSPSVVFDGVHGTLNADESLPYPPKHNDSYSATKAEGEALILKANGRSGLLTCCIRPSSIFGPGDKLMVPSLVTAARAGKSKFIIGDGSNFYDFTYVENVVHAHVCAERALASGGEVCAKAAGQAYFITNMEPIKFWEFMSQLLEGLGYERPSIKIPASLMMPIAYLVELAYKLLGPYGMKVPVLTPSRVRLLSCNRTFDSSKAKDRLGYSPVVPLQEGIKRTIDSFSHLKAQNQPKTEVTETIQWKKQTLIAIVILITLYHNFVATTGSSSVIITAVSKVLLVSSIFMFINGILPEKMKVFGSKKID
The following text describes a protein:
Function:
Regulates transcription and acts as a corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity). May modulate splice site selection during alternative splicing of pre-mRNAs.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.
Sequence:
MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGVKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQDYVASDCEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKKSDKKKKKLQKSKNKHKKRKNKSPSSSSSSSSSSSSSSSSSSSSSSSSETSDSSSESDNKEKKREKEKRKKKKKTKCSESKSSDCKEDKPKNMLYEELSSSHSDRGKAQEKLRFPKQESSGENSMWVHSASDRTSRSHRHSPEKKGSDRNRGIRSRSRSRAESSRRSRSRSPYRQKHREVRSRPHRSPSEEQKGRKGTRSHGEGDHRREHVR
The following text describes a protein:
Function:
MFS-type efflux pump; part of the gene cluster that mediates the biosynthesis of elsinochrome C, a perelyenequinone phytotoxin structurally similar to cercosporin.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTGAKTNQVDQRPLSITDLLHFIPYDLQQTFLFEAILSYGKIYNLYPIKWVFLIALALFEIGSLICGAAPSSVGLIMGRVVAGIGSGGLFAGAILLVAEFKPLNERAFYNGMLGAMYSVASVAGPLMGGAFTERVTWRLCFYINLPLGVVTAVIVFLLVPNNYDSGRDSRRGLPLKKKLQEMDLYGLVVLVPTIICILLATQWGGTKYSWGNARIIALFVVGFVLFVAFVVIEIWQGDRAIVPPSLVKRRTVWACSIFSFCLFGSFLVVAYFLPLWFQAIKGDTATESGIHNLPSILGTTIFSVAAGGMVFGLGYYTWACILGSVLAAVGAGLLSTLEVDSNAAKWIGYQVLYGAGCGFGLNQPLIAIQAALPDFQKSEGTAVVIFMQTFGGTIAIAVAQNVFNNKLVSNILAAGIPVDPAALLSVGATKLQGLVQPQFFGRLQLAYNDSITQTFYVAVATAGLSMAGSILIPWLSVKQAVAPEDAETANTVMPFQHPSSDVDLAMPAILRQSGEIASEDSQSSDIEKVPRNNEVSTYDSQTSEVEKSSVGSTNRKVESIRN
The following text describes a protein:
Function:
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
Subcellular Localization:
Cytoplasmic granule. Note=In the stratum granulosum of the epidermis, localized within keratohyalin granules. In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1 (By similarity).
Sequence:
PDGSGRSSNRRDRPRQLSPSQSSDSQVHSGVQVEGRRGHSSSANRRAGSSSGSGVQGASAGGLAADASRRSGARQGQASAQGRAGSQGQAQGRVSSSADRQGRRGVSESRASDSEGHSDFSEGQAVGAHRQSGAGQRHEQRSSRGQHGSGYYYEQEHSEEESDSQHQHGHQHEQQRGHQHQHQHQHEHEQPESGHRQQQSSGRGHQGAHQEQGRDSARPRGSNQGHSSSRHQADSPRVSARSGSGGRGQSPDASGRSSNRRDRPRQPSPSQSSDSQVHSGVQVEAQRGQSSSANRRAGSSSGSGVQGAAASGQGGYESIFTAKHLDFNQSHSYYYY
The following text describes a protein:
Function:
Regulates microtubule dynamics in uterine muscle cells.
Sequence:
MSPSSSDRLGYPFSTFLDQHSAQLNASAVPPELWHSLYRKLSDQTFDAGDHFQIICEMDENDEKKTLFVRALEDMHNNDEENIFLIDHFISFPAESARKCVESNEKLPERLAALFGIDDDDCSSDGDETVEKIETSCEKEEEEHARRLSEPGLPRHESVDARLSSYSVDDPKKTMTERVMRNLWKFAQTYTVSYQLENGEMEKKHVWYVMDDFGSRIRHSGCPNVRIVPLMFLPQNCAYSIMFLTKPVKIDDEITMDWAANVITAKNPEWRQYLEMPWAEKDFSSESMVPGPPTLEYFTSGRNPDFLADEKDKKTCESAIFSALSVLKKQGKIKIFLQIFADDTQLTEHLKSRQIEYVDDWKAADVIWMIKHFHDYSNLAQENPCAQINQFPFESCITVKDLLAACAMRDPSKNDWYQLTYNLNTQLPEFVARFQNRQKNGEHNVWIVKPWNLARGMEMAVTDDLNQIIRMVETGPKIVCEYIARPLLFPRPDNGNKVKFDLRYIVFVNAIGPVTAYVYNRFWIRFAINQFQLGAYDDLETHFTVFNYLDKEKVLQMKCEKFVEIIEKTYPKLKWTQIQADINSTIRKAIEVAASEPSPRGVAPNTQSRAMYGVDIMLQESPESPDVIKPTLLEINFMPDTTRACQYYPDFADTVFDTMFLDEIDPTKVTPI
The following text describes a protein:
Function:
Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis.
Miscellaneous:
MISCELLANEOUS: [Isoform 5]: Found in a brain affected by Alzheimer disease. May be due to intron retention.
Subcellular Localization:
Nucleus. Note=Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.
Sequence:
MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSSQIPPQPRRAAPTTPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEPGSSCSPTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSLGTTEEKAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSLVEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLNIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLNRGDDPVRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDKLRMEYLSLMHAIVRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVREMCKEFLVLGEAPS
The following text describes a protein:
Function:
Following axon injury, required for recruitment of drpr and glial cells to severed axons and for glial clearance of severed axons from the central nervous system. Together with Src42a and drpr, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark. May be involved in signal transduction on the apical surface of ectodermal epithelial cells, regulating their polarity during invagination. Crumbs (crb) may be the intracellular signal.
Subcellular Localization:
Cytoplasm. Note=Apical expression in cephalic furrow and tracheal cells. Limited to luminal surface and absent from the basal surface.
Sequence:
MSRDSDPMKWYHGNLSREAADELLKQGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRHGGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNLLHRATSKNESKVVFELLKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSFGCQPLHYAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFFARDPDYQNLPELVQTVHI
The following text describes a protein:
Function:
Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
Subcellular Localization:
Secreted.
Sequence:
VFVALILAIAIGQSEAGWLKKIGKKIERVGQHTRDATIQGLGIAQQAANVAATARG
The following text describes a protein:
Function:
Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units. Required for the assembly of the phosphoglyceride-linked form of ECA (ECA(PG)) and the water-soluble cyclic form of ECA (ECA(CYC)).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSLLQFSGLFVVWLLCTLFIATLTWFEFRRVRFNFNVFFSLLFLLTFFFGFPLTSVLVFRFDVGVAPPEILLQALLSAGCFYAVYYVTYKTRLRKRVADVPRRPLFTMNRVETNLTWVILMGIALVSVGIFFMHNGFLLFRLNSYSQIFSSEVSGVALKRFFYFFIPAMLVVYFLRQDSKAWLFFLVSTVAFGLLTYMIVGGTRANIIIAFAIFLFIGIIRGWISLWMLAAAGVLGIVGMFWLALKRYGMNVSGDEAFYTFLYLTRDTFSPWENLALLLQNYDNIDFQGLAPIVRDFYVFIPSWLWPGRPSMVLNSANYFTWEVLNNHSGLAISPTLIGSLVVMGGALFIPLGAIVVGLIIKWFDWLYELGNREPNRYKAAILHSFCFGAIFNMIVLAREGLDSFVSRVVFFIVVFGACLMIAKLLYWLFESAGLIHKRTKSSLRTQVEG