lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase that may regulate the response to iron deficiency and thus contributes to iron homeostasis.
Subcellular Localization:
Membrane; Single-pass membrane protein. Nucleus.
Sequence:
MATPLTGLQHRDVGGVAVMATVNQIDSSSSNTLSKKQSSPIHIFLYFHKAIRSELDALHRSAIDFATNVHVEIEPLLKRYHFLRSIYQHHCNAEDEVIFPALDIRVKNVARTYSLEHEGETVIFDQLFALLDSDMKNEESFRRELASCTGALQTSISQHMSKEEEQVIPLLVEKFSFEEQASLVWQFLCSIPVNMMAEFLPWLSASVSSDERQEMRSCLCRVIPEEKLLQQIIFTWMDGVNMFKKRKNLEGDVTHHCSSISEESCACSSRSIKRESFLRSSDSPLERPVDEILHWHKAIEKELIDIAEAARRIQSSGDFSDLSAFNKRLQFIAEVCIFHSIAEDKVIFPAFDAELSFAQEHAEEETEFDKFRCLIESIENDGANSSSSEFCSKLCSHADRIMAIIGNHFKNEELQVLPLARKHFSPKKQRELLYKSLCVMPLRLIECVLPWLVGSLTEEDAKSFLHNMRMAAPASDTALVTLFSGWACKGRPQETCLSSNATGCCSAKSFLEENDGSGPPLCPCNLPTKRSSLTSRKESNGFGTPGTLTVQVKQSCCVPGLGMNSNKLGTGSTKSLRSLSFGPSAPCLTSSVFNWETGISLIDEGIGWPIDTIFKFHKAIRKDLEFLDIESAKLSESNESFLHQFNGRFRLLKGLYKAHSNAEDNIVFPALESKETLHNVSHSYTLDHKQEEKLFEDISASLSKLCELHDKNNSISRSYAELATKVQGMCKSIRVTLDQHILREELELWPLFDIHFSIEEQDKLVGRIIGTTGAEVLQSMLPWVTFALTQEEQDRMMDTWKQATKNTMFTEWLNEWWDESSPSDASSSASDKNISQGSELHEVLDPNGYTFKPGWKDIFRMNENELESEMRKVSSDPTLDPRRKAYLMQNLITSRWIAAQQKLPQGSESDESDGERLHGCSPSFRDEEKQIFGCEHYKRNCKLRAACCQKLFTCRFCHDNVSDHTMDRKATTEMMCMNCLKVQPVGPVCSTPSCNGLSMAKYYCSYCKFFDDERTVYHCPFCNLCRLGQGLGIDFFHCMTCNYCLGIKLLDHKCREKGLETNCPICCDFLFTSSAAVRALPCGHFMHSACFQAYACTHYICPICSKSMGDMSVYFGMLDALMASEVLPEDYRNRSHDILCNDCGKKGSAPFHWLYHKCGYCGSYNTRVIKVDQVSDFLH
The following text describes a protein:
Function:
Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MLRVRCLRGGSRGAEAVHYIGSRLGRVFTGWVQRTFQSTQAAAASRNSFAADDKVTDPVPKDCPVSSYNEWDPLEEVIVGRAENACVPPFTVEVKANTYEKYWPFYQQHGGHYFPKDHLKKAVAEIEEMCNILKMEGVTVKRPDPIDWSFKYKTPDFESTGLYGAMPRDILIVVGNEIIEAPMAWRARFFEYRAYRSIIKDYFHRGAKWTTAPKPTMGDELYDQDYPIYSVEDRHKLAAQGKFVTTEYEPCFDAADFIRAGRDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFKDPNPMHIDATFNIIGPGLVLSNPDRPCHQIELFKKAGWTIVTPPTPIIPDDHPLWMSSKWLSMNVLMLDEKRVMVDANEVPIQKMFEKLGISTIKVNIRNANSLGGGFHCWTCDVRRRGTLQSYFD
The following text describes a protein:
Function:
Involved in chromosome segregation during meiosis and DNA damage repair.
Subcellular Localization:
Nucleus.
Sequence:
MELPDSPPPLDAPSPPHFLDAPQDRWNVFYPAVQTLVNALGGYEEVESPPDSGIFETVYRPGDSVLGVLKDLKKLWRKDDEDDERTVARCMYRAELMKELVAIVVECAERGEWGRKVALVACDLIAALTWPIDVAQELKEIEDEGPVVTDYASLLRAQLEYKALFLKTTKPLKSILSLMVPCLAKPRKDEKDSRIISLGLHVVRNLLAIKDAVAEGTATGEKEEFAHLQSDLITQLDSLTYLQLFLTLASCADKTDLNPFNVIVLDILHLIFRGIKPSELVQDQKRVPIDSLARLLEKEKKQKALNSRVGSTRHSRFGTTITVKTAEQRVVLHRQTAIIENPGKILDMTKRKKAVVAKRMDDLTVFVNLSSDAMVILQSFSKSFLEICYNTFIESILRDIRMERTKIRPSDNIRVFYLSSFFIEYLLLLRHKLLEKGGSRRLEELPLGLVAQIAEMDSVKWLFARLRICWDDKPKAWTELQACIECFTQILLLIDDMSTSTNEEDVEVAEILQHQLYYNYDILDSALAVVREYKNQSIAYLDSIIHFAYVLLRMLEKYSKTKAFMFIRKRKNTHKKRKERQAASQANADREQRKIPEEYGDEGEEAFAPDEDAPSYAEHAFTFQSFEKRFAQEAVVNTLLTYLERFLEFDGPEPMKRVVGLMHRQVIKAHAEGLYFKVSTLIIFRRILDKQHVLPAAPSSRDLITLITYILRKFFKHVEKEPFTLVEALSSKSRGKWKTVGGGSDDDDDEMAGQRGRIKEKMGPVELQFIKKHKFSWSQQMSIAFAIIWGDGHGYLIKWIVEVLEQVLAAKQEIVLTTDGGINGDEDEEDEDGNARVRRFGRPSDEAISKFTQFDLQPEESEQITAVTSNPHFRLMLKLLSFDLPPPPMELDFEEDVSSEELALAREKSDSAWFLPANVLPSDIEASIGALKQYMEEPPTLDDDPKKLLRRKARATRRRRRSPSVESYDSETGEVRPGHQHKKNPRQKRAKKAVETQNYKSAAFIEDSDDEDPEATRRFFENEERLRREMDELAAQGGHPMMERGVKRKRGKKNGKGAISDTPPPSQRGNDRET
The following text describes a protein:
Function:
Bifunctional mitochondrial folate-interconverting enzyme that has both NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MTVPARGFLLLRGRLGRVPALGRSTAPPVRAPGGPRSAFRGFRSSGVRHEAVIISGTEMAKHIQKEIKQGVESWISLGNRRPHLSIILVGDNPASHTYVRNKIRAASAVGICSELILKPKDVSQEELLDITDQLNMDPRVSGILVQLPLPDHVDERMICNGIAPEKDVDGFHIINIGRLCLDQHSLIPATASAVWEIITRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDATVTIAHRYTPKEQLKTHTQLADVIIVAAGIPKLITSDMVKEGAAVIDVGINYVHDPVTGKTKLVGDVDFEAVKKKAGFITPVPGGVGPMTVAMLLKNTLLAAKKIIY
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling. Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome. Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation. The action of RNF10 in iRQC is counteracted by USP10. May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPQSSPNAAATASDMDKNSGSSSSSTSSGSSKGQQPPRSASAGPAGESKPKSDGKNSSGSKRYNRKREPSYPKNENFITQSRRSNSQKSKTFNKLPPQRGGGSSKPFSSSFNGGRRDEVAEAQRAEFSPAQFSGPKKINLNHLLNFTFEPRGQAGHFEGNGHGSWGKRNKWGHKPFNKELFLQANCQFVVSEDQDYTVHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYSSVHKKDLKSVVATESRQYVVGDTITMQLMKREKGVLVALPKSKWMNVDHPIHLGDEQHSQYSKLLLASKEQVLHRVIQEEKAALEQQLAEEKHTPESCFIEAAIQELKTREEALSGLAESREAVTGVVAALEQLVLMAPLEKESLFQPRKGVLEYLSAFDEETTEVCSLGAPSRPLALPLVEEEEAVSEPEPEGSSEACNDLELAEDSLGEGTICAESSQQEPVTKPSITHLSSSPCYYFYQAEDGQHMFLHPVNVRCLVREYGSLEQSPEKISATVVEIVGYSMSEDVRQRHRYLSHLPLTCEFSICELALQPPLVSKETLEIFSDDIEKRKRQRQKKAREERRRERRIEMEENKKQGKYPEVHIPLENLQQFPAFNSYTCSSDSALGPTSTESHGALSLSPLSRSPGSQADAESWKSKSRCVAQNCSKER
The following text describes a protein:
Function:
Induces caspases and apoptosis. Counters the protective effect of BCL2.
Subcellular Localization:
Cytoplasm. Mitochondrion outer membrane.
Domain:
Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Sequence:
MSLSVEKILLSYLEIDLPRTNEELREELSLFAGGKPRLQGRALFQSEGELETDGNVQLRDSGTIAYEGVEQEVDEELCRRIAAQLAEMGDKLEREMKIKPEVVNGLVDAMLNQTLLEEHLAATVQSLVQTVPPGVEQEMAAVAIAMILTKKAVTNAPSLLQNICRTTTRFVERNYRACLERLARQR
The following text describes a protein:
Function:
Probably participates in deamination of adenosine-34 to inosine in many tRNAs.
Sequence:
MDISAPPNKRARKSPNLDEDITGIRAILSDEFDEDIALIKAHSCELETKQQLQAVIQELSQKLPHFQHLKRVQDRSVLICPSSEIGVSQSLEQHLEQFAFSEHVLRALCQGVRVVEVPERMPRLRVQYEKTLKHWPCKFHPNHYSESLRNGSNFSSAQRTFHKRIGQLLVRLSRDVNANRPVGICVDPRQPSIVSIAGTGEVCRPHEHCCMMLVDFVARSQEGGATKTEVTFTEDFKKDTTLRGIPKAYYDYLMNNEDYKDLTFGAEKSRECKEVDAVQGADNLAKFGPYLCTGYDIYLLQEPCLMCSMALVHSRAKRVFFVKNSENGALATRFQLHSVRELNHHYEVFQFTTKEDEDLT
The following text describes a protein:
Function:
Required for formation of the double-strand breaks (DSBs) that initiate meiotic recombination. Required for crossover recombination and chiasmatic segregation of chromosomes during meiosis I. Also involved in the faithful equational segregation of chromosomes during meiosis II.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNSNDKKKVVRSWIEQFVHDFVEQLSKPTKDSVNVALKRRKHNSWNGSLDSKANERQKVKVFSFPRNETTIAQLFRVLDCVHEAVISDTVITKRDIYYRDVDLFKRQTVVDELLGDISNTIGCSRSDLNVEASAKGLVFGSIHIALENGTVITATKPLLISHHRISSITSTAKWVLVIEKEAVFQTLTEEALADTIIVTAKGFPDLMTRKFLVKLAKALPDAKFFGIFDWDPHGLCIYSCFKYGSNAYSHEPHSQLRNLQLLGPLYEDIFNKNQEFSLKLNKRDIKMITTLLQFEGFQKEPVVREQLQRMLFIQKKAEIQAILEFPSWIKGKLADADKSGKHSVR
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSNISSSSSPVAMKDVVHKLQLCLLEGIKSETQLFVAGSLLSKSDYHDVVTERSIAQMCGYPLCPNSLPSPGEAAVKGRYHISLKEHKVYDLLEMRMYCSTKCVVDSRAYAESLQDERSLVIDTAKLNRVVRLFDGLSVKAEEGLGDSGDFGLRNLSIKEKEDGGVGGGIVSLEEWIGPSNAIEGYIPQHERSSKNKPGRPKREEESIFGEMDFMSTIITQDDGYSISKGKGAETKTSSNSRKKMSHNNNKDKMKTSSSSSSSSSCNVQKKKVTTSNDEESENGNKAKIGSSEPSCSVGGLKSSLKSSSRTNRSVSWADDQTLCEYSGNDPDPEHTFRVASAEACAAALSQAAEAVASGESDAPDAVSEAGIVILPPPGDGAEAEAEPTRLKWPKKTGITESDVFDSFEDSWFDAPPEEFVLDLSPFARMFMSLFAWVSSSTLAYVYGGDDSCYAWVNGREYPRIVVLADGRSAEIKTTLAGCLSRALPGLVRHLRLPTPVSTIESMMGCLLDTMSFIDALPPLRMKQWQVFVLLFVDALSVSRIPAMTPHLANKRRFFQKVFDDAQISSEEYELLKDLIIPLGRAPQLATQSGG
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MEDIGLLPSQIEFLAEDTTITVVPNFKMESLIFLSGEYGPFVPSFPIEIPLWLAISLKKKKKCTITPPDWMTYNKLKAKFQEENKIKDGFIELPENFDEISSLLLANCPDDIKDINKIRILKGDILSRREKKLEESLKSHLNSLTDGESVTTMEFKNFSMMEINKIRASYVSGINDLNKIQNSDNDNNNNNNNNNSNNNNNNNNSQQSQSASNASSRSLFSKK
The following text describes a protein:
Function:
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTRSPWKRLLWLKQEYPDNYTDPSFIELRARQKAESNQKSDRKLSEAARAQIRLDFISFYQTILNTSFIYITFTYIYYYGFDPIPPTIFLSFITLIISRTKVDPLLSSFMDVKSSLIITFAMLTLSPVLKSLSKTTASDSIWTLSFWLTLWYIFVISSTKSKDKPSNLSTNILVALVAVLSSRLSTTIDVFCFLLICIQLNIILPTYLSVTNKVVPIISNIIVYSFLNVALGWIYMLLIFFASVFYITVLPKWFIYWKINYHKRDNDLLSTWDARTPILD
The following text describes a protein:
Function:
Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Associated with the F-actin rich cortical cytoskeleton.
Sequence:
MNPNCARCGKIVYPTEKVNCLDKYWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGVEPERREAQDSSSYRRPTEQQQPQPHHIPTSAPVYQQPQQQQMTSSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPANYVEAI
The following text describes a protein:
Function:
Part of a heme-iron acquisition system. Receives heme from the heme-binding protein Rv0203 and transports it into the mycobacterial cell. Contributes to virulence; Could also transport the mycolic acid-containing lipids monomeromycolyl diacylglycerol (MMDAG) and mycolate ester wax (WE) to the bacterial surface.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVAGSQSLLVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELPGVTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVKGDQSGQTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMVLVAVFGSLAAAAIPLALAVCTVVITMGLVFVLSMHTTMSVFVTSTVSMFGIALAVDYSLFILMRYREELRCGRRPPDAVDAAMATSGLAVVLSGMTVIASLTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALVHWSRRPASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVLGNSLLRQFDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAGGASAPEHSQTIAAIRHRIAQAPNVVSVAPPRFADDNGSALLSAVLSVDPEDLGARDTITWMRTQLPRVAGAAQVDVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLMLLISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWARGLGFPALHSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYGVRTSARTITSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMAMFDRWNWWLPRWLAHILPSVDFDRPLPKVDLGDVVVIPDDFAAAIPPSADVRMVLKSAAKLKRLAPDAICVTDPLAFTGCGCDGKALDQVQLAYRNGIARAISWGQRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRRSPVETTNVALPTGDRLQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAPETAAAVLAGMDRYYSCQAPGRQWMATQLVGRLADPQPSDLGDQSPGADAQAKWEEVRRRCLSVAVAMLEEAR
The following text describes a protein:
Function:
Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.
Subcellular Localization:
Nucleus speckle.
Sequence:
MASHPLVTPEQVASAGRAAGVCYYCGAPLGAAHHSYCTLVKALPQAPYSAPTVPPPHHQYDSQASTPGYEQYNQLPASGHTFFQSAAPAAGSAVDHAQWQPYDSQWFDAGATPPDQDWHEVAPPSPPPPPPGPEEGPPPLPPEDGHAPLPPAEQPPPPPEEPAEGSWEAGHSWNGAQSGQIEPPWGLQAGSSGMQVMSLWTHEQGPAPPDQQDALSGRVRWVDGPHPHGGNPQWEGLAWGHAGGAAAAASSSPPDHEQPPDHLSSGQNQPLSAPQGSFHPSSSAGPLEGQVFAPPPWQRPAAQPDGAGLASGAASTADVQPAGGAGRGSGMESIRDYYAAPGQPQIGAHMLLSMLQGGPYLGAPDPRPMMAPAMPLPFPLHHTPPLVSVPEQPRRVDARDIFKQPGRSTRPDRFVVILRGLPGSGKSHLARALRDVEVMNGGSAPRVHTMDDYFVTEVEKEVEVEDGRGRKRKSAHTAMEYVYEPELEQAYAASMLKAFRKTLEEGRFHFVIVDYWNLVVSEFEPYWKAAKSSGFEVYVLQPAKLDPEACARRNIHGFTLEAVTDMARRWEPLPPQYLQLDVQSLFRGDLLDTGDIAEVDMDADPDPAPPAAPAAAAAGKRPLYESDEEDADTPHHAPPSRPSARPDKGAFRERDTKWRATDSPSRRQPPQPGATSGTASKGGPRKEVKWADLEGEKEAAKGFRIGVDLSKKRKLEIGPGAGYTQDQTGPLQHSSAHEHAAWARKVKAQVRDEAEAFKAVVARRRQRIGVEEDDD
The following text describes a protein:
Function:
VirB proteins are suggested to act at the bacterial surface and there play an important role in directing T-DNA transfer to plant cells.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MNDDNQQSAHDVDASGSLVSDTHHRRLSGAQKLIVGGVVLALSLSLIWLGGREKKENGDAPPSTMIATNTKPFHPAPIDVTLDPPAAQEAVQPTAPPPARSEPERHEPRPEETPIFAYTSGDQGTSKRVQQGETDRRREGNGEDSPLPKVEVSAENDLSIRMKPTELQPTRATLLPHPDFMVTEGTIIPCILQTAIDTSLAGYVKCVLPWDVRGTTNNVVLLDRGTTVVGEIQRGLQQGDARVFVLWDRAETPDHAMISLASPSADELGRSGLPGTVDNHFWQRFSGAMLLSVVQGAFQAASTYAGSSGGGTSFNSVQNNGEQTADTALKATINIPPTLKKNQGDTVSIFVARDLDFSGIYQLRMAGRAARGRDRRP
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular Localization:
Cytoplasm.
Sequence:
MAPVTSKKSKSVKKFVVDVAAPVENDVFDQESYVKYLVEHVKVDGIVGNLGNDISITAESDNKVVVVVSGNGSFSGKYLKYLTKKYLKKNQIRDWIRFVSVKQNQYKLQFYAVAEDDEEEEDEE
The following text describes a protein:
Function:
Toll-related receptor. Probably specific to larval innate immunity. Involved in the tracheal immune response of larvae to Gram-negative and perhaps Gram-positive bacteria; upon infection it negatively regulates the immune deficiency (Imd) signaling cascade specifically in the respiratory epithelium to prevent the overexpression of antimicrobial peptides (AMP). Involved in the NF-kappa-B-dependent apoptosis of unfit cells during cell competition. Involved in neuron-specific glycosylation. Positively controls the neuromuscular junction (NMJ) growth in presynaptic motorneurons, probably via the JNK pathway. During development of the peripheral nervous system, may function in the NF-kappa-B (rel) regulatory cascade to repress expression of the neuron-specific genes sc and ase in non-neuronal cells. Promotes heterophilic cell adhesion with 18w in vitro. May have a minor role in leg development. May be involved in determining the proximal cell fate in the wing, possibly by negatively regulating the Dpp signaling pathway. May also be involved in the Dpp signaling pathway in the eye. Possibly functions with 18w and Toll-6 during convergent extension, to help direct proper planar cell polarity, cell intercalation and axis elongation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Apical cell membrane. Note=In larvae, localizes to the apical cell membrane in trachea epithelial cells.
Sequence:
MLATTHMLYVLIATCVIPIFGAALSKTVLYQAPDECRWSGGGEHDITLVCHLRTINSELENTNFSVIQPQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQELRNLTIRTHNGDWSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLPSYLNELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFRQEMRVWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDPDLRLYLKTNTYLQWGDKLFWQKLRFALPDVSSSQRSNVAGQSCHVPINHASYHHHHHVHQQAMPLPHSVHHHQQQFMLPPPPQQPGSFRRQPSLHQQQQQQQQIRGNNNTTQQQQQQQAALLMGGGSVGGPAPQMIPLAGGIQQQSLPLPPNQQPTPASRNLHM
The following text describes a protein:
Function:
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAFTPASEVLLRHSDDFEQSRILFAGDLQDDLPARFECAASRAHTQQFHHWQVLSRQMGDNVRFSLVAQASDVADCDTLIYYWPKNKPEAQFQLMNILSLMPSGVDVFVVGENRSGVRSAEPMLADYAPLNKVDSARRCGLYHGRLEKQPQFSLESWWAEYNIDGLTIKTLPGVFSRDGLDVGSQLLLSTLTPHTKGKVLDVGCGAGVLSAALASHSPKVRLTLCDVSAPAVEASRATLAANGLEGEVFASNVFSEVKGRFDMIISNPPFHDGMQTSLDAAQTLIRGAVRHLNSGGELRIVANAFLPYPKILDETFGFHEVIAQTGRFKVYRTVMTRQAKK
The following text describes a protein:
Function:
Member of the two-component regulatory system SasA/RpaA involved in genome-wide circadian gene expression. One of several clock output pathways. Participates in the Kai clock protein complex, the main circadian regulator in cyanobacteria, via its interaction with KaiC. KaiC enhances the autophosphorylation activity of SasA, which then transfers its phosphate group to RpaA to activate it. In addition to its output function, recruits fold-shifted KaiB (KaiB(fs)) to KaiC to cooperatively form the KaiB(6):KaiC(6) complex (independent of SasA kinase activity). Required for robustness of the circadian rhythm of gene expression and is involved in clock output, also required for adaptation to light/dark cycles; Plays an important role in glucose metabolism, important for expression of genes involved in glycolysis, gluconeogenesis, the oxidative pentose phosphate pathway, and glycogen metabolism. Required for heterotrophic growth. Overexpression from the psbAII promoter leads to altered levels of genes involved in carbon metabolism, increased levels of transcripts for clock oscillator genes in the light and the dark, complete loss of glycogen accumulation, decreased levels of metabolites of sugar catabolism and increased levels of amino acids in the light and increased levels of SigE protein.
Domain:
The N-terminus interacts with KaiC, while the C-terminal histidine kinase domain autophosphorylates and is probably responsible for self-oligomerization. The N-terminal domain stimulates the C-terminus to autophosphorylate.
Sequence:
MSSSSELGNASSVPLQFLLFIDDRPNSQDSVQEIGQCLTNLLDGHSHDLQILQISKHPHLVEHFRLVATPSLIKLQPEPRQVLAGSNIIQQLQKWWPRWQQELAMDPNPEDTGQSPSCPREISSVGYSGELMKMSDELFLLKKDKEELLQQIQFKDQILAMLAHDLRSPLTAASIAVDTLELLQHKPIEEQKPALRSQLLYQARKQFKIMDRLIEDILQASKNLNSQFQVHGRPLAIADLCQEVLELYQAKFSKKNLTITYDIPKDLPNVFADEELIRQVIANLLDNAIKYTPAHGSITVGALHRTTQKVQVSITDNGPGIPNSKQETIFEGHFRLQRDEQTDGYGLGLSLCRKIIQAHYGQIWVDSRPKQGSSFHFTLPVYR
The following text describes a protein:
Function:
ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.
Subcellular Localization:
Nucleus.
Sequence:
MELDDSWDPDPLPNSRVGNHSQPRHKGQAARNSKMQSQYYQHSQTSHPQHSDHNAPINLDNESSDDESSSNEYPILVQQPQATHKRMRSPIQPVPDGRKRHQSEHPSGIGRCRKTNIEEAMHDHYPHVLQSRKKLVPRNDIRYQATENKHHSGYFDVESTLPKSRKSDPRRNSRTGDAYQDQVYVEEGDFGEQFIRESSFIAYKGNSFAKERMKQEHMEQERNYNPVPPGTFTHEPTGQYHQQSTRANHELVLTPKARQRLDYSRAQSVGPRSSYDDSGNLYPGPENSISSARNLRKRQELQLASPIWPGREYVMQKPSSLHRNQGNNEKLTFADLTPHTPRKPPARSSSVTPSGAQAVANQPKEYNYGFIDDDDINETPLEEALQGRPNFQTNIQNAPMDLMRALPKSSAFRRSDSEAAKYIYQSPSGGSRGADASNITIDLVTPERAVSARASMPFIPHHWTPARRGPIKVSNTRESFMQDGPGANGVETFAGDAQERQAAASSTSKVQSPEEIARQRQAAKKIVNRELIADREALQKDLFGEVVSETEEEKRERDEAKRLQAQRLREAKEKQDAIDAKVKRQKNELKAQKERDKKDAEQREKNKDVASRKANRDADRRHQSLREAQNAEKRRKDAHNKLQAKKEELAALKALEEQKQISDRENREQMNKLERDFQRLAAQVTAQTAASLKPARKSATENGATNTEETSPLQATLPTNMEVDNEDSLFFPETQITPVEASSDVQVTNQTQIPEAVNSDSTMVPSVEQDQSPASIAEIFAKTIPNTSGGNVEDREAEREATRKKRPGEHAAAKRKREKSVAADPSPNTTADGIEASRKKIRAETKARIDALKKKELDAKRDTIYQKKTVEYRKKKEKEFRDKARQDGRELGEAELETMLDKLMEKRERDKNRRNRRRSGENPSSEHENEAVPNSSLPNGLGTAAQVSSSDTASETNHVQEDDDPKTQARQDHKVRTAESLKALAESHAARRCQTSSVKELGPLFSDSSSSESEEDPDDEETTQRYIENVRKNVDVTKANNTFDEVQSGTPVVEEVDLEKDFEAAFEEELLIERGTEMAATALNTDDHSAQVFEPMPDMTPYFEGSLTQASSFTLAEQSTQLTTPSQISQPEREKPQKSPSYSMVNVYMVMTQLILHEHEDEAALKKKFFDVDKANRYAQTLVNEYRTKKYMQQEIVEKWDREYNYSCQITHNDHKITKVFVKAVPMNPKDIDKFDPHQINPRFANQYYTVRYEKIIEKLDPETQKVCMIERTNGIIDDSKLYTALEMANHAAAEYFLEIIKPKEGVEEHHNLYYEEILPQVREGRDDCAKGDQMFQCDLNNEMVPWADFKSFKVEVEASKTEGPIN
The following text describes a protein:
Function:
Required for vacuolar protein sorting; may be required for the consumption of transport vesicles containing vacuolar protein precursors. May bind a Rab GTPase such as VPS21.
Miscellaneous:
MISCELLANEOUS: Present with 4280 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Domain:
The CUE domain (Coupling of ubiquitin conjugation to ER degradation) is monoubiquitin-binding and is required for intramolecular ubiquitination.
Sequence:
MTDDEKREILKEFDPFSQLEQANGNPDKDVKFKKDDPNRAAAEETNRDISAQDKGDEEPFYDFQIFIKQLQTPGADPLVKYTKSFLRNFLAQRLLWTVSEEIKLISDFKTFIYDKFTLYEPFRSLDNSKMRNAKEGMEKLIMGKLYSRCFSPSLYEILQKPLDDEHMKDLTNDDTLLEKIRHYRFISPIMLDIPDTMPNARLNKFVHLASKELGKINRFKSPRDKMVCVLNASKVIFGLLKHTKLEQNGADSFIPVLIYCILKGQVRYLVSNVNYIERFRSPDFIRGEEEYYLSSLQAALNFIMNLTERSLTIEDHEDFEEAYQRNFKQLAEEKEEEEKKKQLEIPDELQPNGTLLKPLDEVTNIVISKFNELFSPIGEPTQEEALKSEQSNKEEDVSSLIKKIEENERKDTLNTLQNMFPDMDPSLIEDVCIAKKSRIGPCVDALLSLSE
The following text describes a protein:
Function:
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Sequence:
SHSEIITCSMPTGTGSRAETSIFPTREDMQKELLKYIQRIIDDQVRFPGFISIGLSGGSMPKILGPVFSKLKIDPDRLRLFLVDERIVEISEPDSNYGQWMQSLPKAFHACLAAADLIDMPYRADRSGFAYDVGRTALAYESKIKNHHIGPEVYGRFPRFDMLFLGMGPDGHTASIFPNSKLYRLKMDSTAWFVGVDDSPKAPPQRITLTMSAINASANVAFICTGDDKATVLRAVLDRDMQYPAAAVHPINGTLRFFLDTLAAAKL
The following text describes a protein:
Function:
DNA-binding protein which is required for efficient transcription-coupled nucleotide excision repair.
Subcellular Localization:
Nucleus.
Sequence:
MNIKRNQNNSIDNNLSIDSNPSPIKKVKNHLDFSKSYNEDDEPSNDLDLSFNTSNISNLSNINGEEDNDDDDRENEPKDIDNPNPSITTTTATSTNSTLVKKTNNFLDFNFAFEPNKEEDDEEEDLNISLTTEDILLSQIELLKAEWDYITYNKSPPLVLQSVYHQSNKDSERSIQILKKKGTIRLFQIATSLNDYCIIITTDYIKNIELLKIENTTIPNKIKPETLTNNMKNSSPIKSAPIDTILLKRSEILDLFIKKLIPNFNEVSITRSKLFQLLSIVNDDHHQQENIITHLVQCGLLLQKDDCTFTFSVPGAGGFFLNLMKGRKEILSNIQRLKYKEILKKDLLKKKLKYSNVQMQLLIKDLLGLNKIKIIPTTQGELIRCVQFDEL
The following text describes a protein:
Function:
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Subcellular Localization:
Cytoplasm.
Sequence:
MRRKVLAGNWKMYKTRGEARAFLEAFVPLISPGAENREVILCGPFTCLDLLSAQAGPYAVGAQNVHWADHGAYTGEIAPQMLVELGVHYVIVGHSERREYFNETDSTVNRRLNNAQDHDLVPILCVGETESVRKDGITEAHIRSQLDRDLELVDMRRLIIAYEPIWAIGTGKTCEANEANRVCAMIRKHVNFEGVPILYGGSVKPENIDELMAQSDIDGVLVGGASLEAKSFARIVNFEV