lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the pathway of tryptophan degradation. Reduces FAD/FMN to FADH(2)/FMNH(2), which are subsequently used for the hydroxylation of anthranilate. It can reduce either FAD or flavin mononucleotide (FMN) but prefers FAD. The enzyme has a slight preference for NADPH as acceptor.
Sequence:
MKLLGISGTLVGTKTCILVEQVLVEAKRICPEVDIQLLDLKDYQVEFCDGRQQSSYNEDTQKVIELVSVADCYVIGTPIFQGSITGALKNLFDLISPQALRHKVMGFVANGGTYQHYLVIENQLKPIASFFRAFVAPGSVYAHTDHFNEKNELVDPEVRERVAQLAWEVVHMHWSLKSGGVHAHR
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MADRDKIQILKDALYEAARDHGSDQRLFTQRDLLDMQVIPQDNIGLLMQVIQILCDEKLFVGNTTASGLSWRWRSREDAKKYTSLPNSEIMMVYAMVDEAGADGIWNRTIKNKLNMADSLMKHCIKYLEQKGYIASMKNVEHPNKKMYIKANLRPSDRATGGPWFTEGELDTAFINELQEIVFDFIKQKSTYTSHGGGAGVPGVGAQGGGAQQREKNPKKGVVQGTIPHSEDISKGTKRSAGEISNDDTAAPAPAKKTRPGKPQLLPLPAGYKSYPTVSDIAKFIHHAGITNNTTLSEADIQQLVDVLYYDGLVEPVKVNGRKGYRVTRIPKQDPRTCNQRRLDHDPTKGGIVTSFMGVEPSASGLMEAPCGRCPVYDMCEEGGPVSPSNCVYFRRWLDGDEVQEQVISI
The following text describes a protein:
Function:
Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Note=Extracellular matrix of elastic fibers.
Sequence:
MAGLTAVVPQPGVLLILLLNLLHPAQPGGVPGAVPGGLPGGVPGGVYYPGAGIGGLGGGGGALGPGGKPPKPGAGLLGTFGAGPGGLGGAGPGAGLGAFPAGTFPGAGALVPGGAAGAAAAYKAAAKAGAGLGGVGGVPGGVGVGGVPGGVGVGGVPGGVGVGGVPGGVGGIGGIGGLGVSTGAVVPQVGAGIGAGGKPGKVPGVGLPGVYPGGVLPGTGARFPGVGVLPGVPTGTGVKAKAPGGGGAFAGIPGVGPFGGQQPGVPLGYPIKAPKLPGGYGLPYTNGKLPYGVAGAGGKAGYPTGTGVGSQAAAAAAKAAKYGAGGAGVLPGVGGGGIPGGAGAIPGIGGIAGAGTPAAAAAAKAAAKAAKYGAAGGLVPGGPGVRLPGAGIPGVGGIPGVGGIPGVGGPGIGGPGIVGGPGAVSPAAAAKAAAKAAKYGARGGVGIPTYGVGAGGFPGYGVGAGAGLGGASPAAAAAAAKAAKYGAGGAGALGGLVPGAVPGALPGAVPAVPGAGGVPGAGTPAAAAAAAAAKAAAKAGLGPGVGGVPGGVGVGGIPGGVGVGGVPGGVGPGGVTGIGAGPGGLGGAGSPAAAKSAAKAAAKAQYRAAAGLGAGVPGFGAGAGVPGFGAGAGVPGFGAGAGVPGFGAGAGVPGFGAGAVPGSLAASKAAKYGAAGGLGGPGGLGGPGGLGGPGGLGGAGVPGRVAGAAPPAAAAAAAKAAAKAAQYGLGGAGGLGAGGLGAGGLGAGGLGAGGLGAGGLGAGGLGAGGLGAGGGVSPAAAAKAAKYGAAGLGGVLGARPFPGGGVAARPGFGLSPIYPGGGAGGLGVGGKPPKPYGGALGALGYQGGGCFGKSCGRKRK
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTEVGPADRRKLLHSKRAEANSIVTSRKRKLRELYAVATDEDGFPNHDLNDLDTRPASPGEAKFLFDCEILQGRRLAERLLPVFQRPRFDTLQHIATADESSLGHGPHVVQQVQPSPLIHPNHTIPKNVQHNGLPSPAPPASSIRHEPERTVPYNQVPNGAAGPQEALKAFAPRQEFQKLAPVQGSAVKTADGPSGESKPPAKETPVLLAPAAPHGNGRWNGIINNAPQGRVLPTPQTVAPPATAPTSTTKTANLGEGRAGPKDDTVSRGDAEEKARPKPTITSVNQLLSNGDSIRYPDTLSSPSSTVQSAPTPLGNEASASTSPDNEASQSFDKPVSRPEQELRRATTDNKGVGQFTGPSVAVPELRPQPQQPGVYANGAPEVPISSAPSVRPAASGAEAQLLQESAATRTSQVIGKAGVAGPHGAHSTGGLQTQHPSAVNGEVRNMMNGDIPGKHVASQASVSTGVAVTKAALPEVAKQGPLPQGPESRNNRADVGPTPMDLDRIPTAQAPKPIPSVHAVQEKAPSQESARQPQPSSTAPSTTPPSAQPAVSLEKTVPGIQINAPPETETETQARTSQSSHPDTESAVADEEGDMPPGLLTHRLKSLSTRLRERRRKSVPTVVFGKQYRKPRFSDDTALIVNKPKPPGHIPSEDYFVTLFIESFARTSSWMKPLEKLLHSAHKTVSTSDQTLSILDHQACKILRRVYHLQQHDKWSLRQPVRCLEPARPASHQDLLIKEMKWMRTDFREERKWKRAVARNLAYACAEWYYSSPADRKLLQVDAKIPPVRAVDNADTSMADAPETGESLVPELDHSDSPVGNDEEVPELPITTIAPATIFALQDDEVVFELQPSRTADLLLENLPMYGSPLKVPKFDWIIPDYDPDAKWKRPAVPLSKYVEGEMVLDVKPQPQKRSRFQFQGEDEEEEEEYVFGAQPDKGAKLPPTSTDVALFAPEMKLTRDRLHAGHQFRPPSEHPMPVQSFFESRIASQWTLAEDDQLRALVREYSYNWSLISSMISSRSSFPSAVERRTPWECFERWVNLEGLPSDFAKTPYFKAYQARIDAAGRTILQHNQNAAQGQQVGPNGAVAPIPRKRPTNTMRVERRRNQKHLALFDAMRKLAKKREAAAQKQQAQATMTAMRKTNEQQRQQPQQQLHLQAKTPQEYSLMRAARDQQIAEKMAHLAARQHEIIQKRLLTQRQAQLAATPGVAQVPQTAAQLAAANSLNNAAARLNIPGQMAVTAQKLAPGRVPMQAPAGIPTVPAQLAASGLVPPLPVAAIPQAQLQAMQAQHRLPMVNPTPDINLVMQARRIQDQQRAVAVQLQQQQHQQHQHQQHPQQPQQQGQVQQQVVSQQQQQQHQPQQQQQPQQQQQLQQQQPQQQQPQHQQVQTPQPAQQQPQQPQVTQQPPPVPQVQINGVQGSPTPMRPVVNSLNNGVYMSSVSAQAMMASFNAANSVAGMVTSPGAGLSMPMLPAGSPRGPQIPAQQLPYTHIHTRLKEFETHFRNKNPGATQDQIRQMATEHLGRLIVQTQQHAMNAAAGGVGHSLGTVATTTSPHQYAQLLRAQQQAQAQQAQAQQQAPQPAQSQLTPAQLAQAQAAAAQKQKQAAAAAAQAKVLAQAQMQTQTPAHQPHQPQAQPHVQAQAMAAAQLQAQVQLQAQAAAQKQAAQAHPQAQSQGQGQPPQQTQRAHQVQQVQGQQAHQLPQGSQSQQIQQQVQQSPQARQQSQQPQMVRQPVQQAQQPQQLQQPQQSQKTPQMQPQQQVQTPHQQAQKAQQSQQAQLAQQQQHQQQQQQQQHGQAQSQGQIQGQGQAPGQGQAPGQGHAQGQVQGQVQGQVQGQVQGQVQGQVQGQVQGQAPGQVQPQHAQHSRHTPNSQHAQHTQQAQHARNAQQAHHTQQVQQAQHVQQPQGLQGQRHGQVHGNGQQLHQQHQHQQQQPQQAQQTQQQRQQVHPAPQLPQAQPPQHSHQAQAQHPQTQQAQAPQAQAQQPQPPQQAQAQQVQQPQQAKLTQQAQQAQQAQGQQAQGQQAQGQQAQSQQARAQQAQVQQAQVQQAQVQQAQAQQAQAQQAQAQQAQAQAQAQSHGQMQPQTQPQQQPQPQPQSQPQAHQPQQASQQVQHGLVGQQGQQNRQGQQGQQSHQVQQAQQPQVQQAQQPVATPQSASQTSQNSQPAQQAGMAQQQQGQGSGSAAPAPTK
The following text describes a protein:
Function:
Thioesterase; part of the gene cluster that mediates the biosynthesis of pyranonigrins, a family of antioxidative compounds. The first step of pyranonigrins biosynthesis is performed by the hybrid PKS-NRPS synthetase that condenses 6 malonyl-CoA units to an acetyl starter unit, to form a 1,3,5-trioxotetradecane-6,8-dienyl-ACP. The enoyl reductase (ER) domain of pynA is likely to be functional during the first two rounds of polyketide chain extension, to generate the saturated C-C bonds of the alkyl side chain (Probable). PynA subsequently forms the amide bond between the acyl chain and L-serine. Although pynA has a terminal reductase domain, it appears to require the thioesterase pynI for the release of the straight-chain intermediate from pynA via the formation of a tetramic acid pyranonigrin J. The methyltransferase pynC then coverts pyranonigrin J to pyranonigrin I via N-methylation. The FAD-dependent monooxygenase pynG catalyzes an epoxidation-mediated cyclization to form the dihydro-gamma-pyrone moiety, followed by pynD-catalyzed oxidation of the alcohol to the ketone and enolization to yield the characteristic tetramic acid-fused gamma-pyrone core of pyranonigrin H. Pyranonigrin H is substrate of pynH for dehydration-mediated exo-methylene formation from the serine side chain to produce pyranonigrin E, before the oxidase pynE reduces the exo-methylene of pyranonigrin E into a pendant methyl to form pyranonigrin G. The FAD-linked oxidoreductase pynB performs the reverse reaction and converts pyranonigrin G back to pyranonigrin E.
Sequence:
MEPILHIQGDAHSSLTPLIFIHAVSGLAWPYMALGNLSNTSDPARSRPVYGISSPVYSSELQPHGPYLLGGWSMGGMIAVKMAEILQAKKETVQQVILLDSINPEKYPAFVNEEEHRIIADGLFTNVCQAMGMADLADDSDDEDNRSDASDASDDGSTMSDEEEEDDNLHRLFSTMRRHIHASTLSISSTEPGKLLPPNSVCHTSVTLVKCTQLSETVPALFSARQRCIRRCALHPTLQWRPQNFDRFRTLLIDARHDSLFDEEHVEEVTSMLRQILESC
The following text describes a protein:
Function:
Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.
Subcellular Localization:
Secreted.
Sequence:
MRFLCLFACVLSSAVVQGSLFVLSESQDQKIIPEILEKDNSIWPYHHEVFEFHPEHKDLSTGLVRPLCVLHTLGEGADDSYNFEKAVHQCGRGGIVRLPDANYTISRPLDIYLSNSVLDLHGWLSFSANVSSWIENRMPLGFQNQSLAFVVRGNDYILEGNDKGGINGNGQAWYDYAKDYGNKFGRPMSLAIKNSKNVIIKNFSIVQPQFWASLIWGSENVYIKDFYVNATSFNPESSSDQKNWLQNTDGSDTYQSHNVTYENMIYQGGDDCVALKPNSTSITLRNVTCYGGTGIAFGSIAQYAGVKDVIEDVFMEDIRLYPSNQCPAYQGVYFKSWLGYSIGQPPNGGGGGYGYCRNVTVKDVYMEDIWHPLVVQSDLTYLTLDREKFTDSGLFEWYDIHLKNFTGKALGNRIAWMSCSKLTPCHDWTFEGMDIMPGKQDHPEIHYTCNNFVLGGNDGLNQCHPSNSKLETENGGTL
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system CbrABCD for uptake of the siderophore achromobactin. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSHAVIPTGRRIAPGQVLAGGGVCLLALAVLSLMVGPVWIAPSQVLGALWHPDPLNVSHILVTSTRLSRTLIAIVVGAGLAVAGALMQVLTRNPLASPGLFGINAGAMFFLIVCVSLFPKVAMSVWLWSAFAGAAVAGCLVWLIGTMGKGSLNPLRMVLAGAAITAMFAAFSQAMLVVNQEGLDTVLFWLAGSVADRELATVLPLMGYCLAALVGALLLSGQVNVLNAGEAIARGLGQRTGRIRLLMSLLVVALAGGAVAMAGSIGFVGLIVPHMARKLLPADHRWLLPGCALLGACLLLLADILARVVIVPQEVPVGVMTALFGAPFFIFLLRRGGRYG
The following text describes a protein:
Function:
Involved in the production of sphingolipid metabolites. Phosphorylates sphingosine and various sphingoid long-chain base (LCB) products, such as phytosphingosine (PHS, 4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine, D-erythro-dihydrosphingosine and D,L-threo-dihydrosphingosine. Is required for abscisic acid (ABA) signaling that mediates stomatal closure, inhibition of seed germination and root elongation. May function upstream of PLDALPHA1 and phosphatidic acid (PA) in an amplification response to ABA that mediates stomatal closure.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein. Note=Associated with the tonoplast.
Sequence:
MDRQPERENDELPSPAIISDRVLVNGVVTPLTLTAEGELRSTESGRRKSTLAKEILSFVVEGNKVRVKTLVEKGGGICCRGSAGDYARNDFVFEPLSDESRKLWSDKFHQHLVSLGRPKKLLVFVNPFGGKKTARKIFQEEVKPLFEDANIQLEIQETKYQLHAKEIVRSMDVSKYDGIVCVSGDGILVEVVNGLLEREDWKTAIKLPIGMVPAGSGNGMIKSLLEPVGLPCSATSATISIIRGRTRSLDVATISQGTTKFFSVLMLAWGLVADIDIESEKFRWMGSARFDIYGLQRIICLRQYHGRILFVPAPGFESYGQRASCSIDKEPSGSDKTLVYQGPDSKLENLDWREMKGPFVSVWLHNVPWGAENTLAAPDAKFSDGFLDLIVMKDCPKLALLSLMTKLSDGTHVQSPYASYLKVKAFVLEPGARIDEPDKEGIIDSDGEVLARGRKSYKCDQKALMSYDKLQISVDQGLATLFSPE
The following text describes a protein:
Function:
Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MIIYILFSLLAAVIVHLVYKKQTGFKLKGKHIVVVGGSSGIGKELVYELLKENIASISVISRSLDKLRSVVDDCPSEVCTKSTPLNVGSLKSKIEIYSCDITNKIKVKETIAQIVSKNQGGKIDCLINCAGFAIPGYFIEQDEEIFEKTMQLDYFGSLYATKEVVPLMIENGGQGGHIVFVSSTCGLVGVPGYSTYCPSKFALRGLAETLRSELKPYKITFSVVYPPDTDTPGYQQENLTKPEETVAISGGGKAVSPLEVAKSIVSGIKNGDYHIAYDVPTKLCAVLSPGLTPFYFSFFDILLAPICRLVGIIAMNQNDAEVLKSWKKRNQLKK
The following text describes a protein:
Function:
Possesses strong A transferase activity and weak B transferase activity.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity).
Domain:
The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis.
Sequence:
MDLRGRPKCYSLHLGILPFIVLVLVFFGYGFLSHKIQEFRNPGGETCMATRQTDVQKVVSVPRMAYPQPNVLTPIRNDVLVFTPWLAPIIWEGTFNIDILNEQFKLQNTTIGLTVFAIKKYVVFLKLFLETAEQHFMVGHKVIYYVFTDRPSDVPQVPLGAGRKLVVLTVRNYTRWQDVSMHRMEMISHFSEQRFQHEVDYLVCGDVDMKFSDHVGVEILSALFGTLHPGFYRSRRESFTYERRPKSQAYIPRDEGDFYYAGGFFGGSVVEVHHLTKACHQAMVEDQANGIEAVWHDESHLNKYLLYHKPTKVLSPEYVWDQKLLGWPSIMKKLRYVAVPKNHQAIRN
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis. May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor (By similarity).
Subcellular Localization:
Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.
Sequence:
MDSDSTVTSLEENTENFCTNPTRDILAEGITNLFKPTIERLDERVASTIQLQAELRGQLDALAAQLRDIEKAQSQIPEFADKVKELLNVKHKVTVISNVLVTSQERLTGLHKLIEKEQRRRQALLDSALSTNIS
The following text describes a protein:
Function:
Required for cis-Golgi integrity and efficient ER to Golgi transport.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Single-pass membrane protein.
Domain:
The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
Sequence:
MGLCKCPKRKVTNLFCFEHRVNVCEHCLVANHAKCIVQSYLQWLQDSDYNPNCRLCNTPLASRETTRLVCYDLFHWACINERAAQLPRNTAPAGYQCPSCNGPIFPPANLAGPVASALREKLATVNWARAGLGLPLIDEVISPEPEPLNSSDFSDWSSFNATTTPVQEERESTAAAPVFYSQVPRPPPSPSRPEQHTVIHMGSTEALTHAPRKVYDTRDDDRTAGVHGDCDDDKYRRRPALGWLAQLLRSRAGSRKRPLTLLQRAGLLLLLGLLGFLALLALMSRLGRAAADSDPNLDPLMNPHIRVGPS
The following text describes a protein:
Function:
Plays a critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has replication fork regression activity, unwinds stalled or blocked replication forks to make a HJ that can be resolved. Has a DNA unwinding activity characteristic of a DNA helicase with 3'-5' polarity.
Sequence:
MSELKRIPTTEIKGIGEETAKTLKELGLSTVHDLLWNFPYRYEDYRLRDLSEVAHEERITIQGEVLTEATVAFYGRKKSKLSFRVSTEGQVIKIDFFNQPYLKSKISVGETVTISGKWDKSRAQVTASKIKIGAVESEEELEGVYRLKGTLRNKTMQKYTRLAFDSYSQDIEEVIPGNLLEKYQLMDRLEAVRILHFPKNNEELKQARRRMVYEEFLLFQLKMQFFRKIEREKSGGISINYDVEDLRHYIDSLPFPLTKAQKRVVNEICGDMLSHFHMNRLLQGDVGSGKTVVASIAMYAAAKSGFQSALMVPTEILAEQHANSLVELLQPFDITVGLLTSSVKGKQRRELLAMLENGSIDVLIGTHALIQDEVIYHRLGLVITDEQHRFGVAQRRVLREKGEYPDVLFMTATPIPRTLAITAFGEMDVSIIDELPAGRKEIETYWVKHQMLDRVIGFMEKEIDKGHQVYIICPLIEESEKLDVQNAIDVFNILQNKWGTKYIPGLMHGKLLPADKEQIMRDFNDKKIDCLVSTTVVEVGVNVPNATMMVIYDADRFGLAQLHQLRGRVGRGVDQSYCILIADPKTEVGKERMMIMSETNDGFVVSERDLELRGPGDFFGRKQSGVPEFKVADMVHDYRVLEIARQDAVHMIFEEDMLENKNYEKLVALLEEEGVFTEQKLD
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MFAGRYRVGKRDGKTPTGVVVPGQEGNTRPITSPEIEEANSLPPLVTEVMSVFNPIPYALSLLDGSSLGRDYESFCDIHDSLEKAMDLIVNDYHQAFNSAIQTFSSVVDTISESQKKVQEMRENLEKSKNWLECKRFDLLHLWVKSIQFKEMSRILESMQVGFDELQRSPTKIQTLIDGKYYLTAVKTLVSSIRTLNASDVVDIGAMDTVKEKLAQMSKQVYDLILEEIHDHLYLKTAPAMARIEPILNTSKENVEIAIGNEYQFFTRTKLDYVFDQIKPELFDDFESNPETNSFCYLQALVESLKVLDKLEDGLKVIDSRVTQELFGVVEKTIEEQEHRHVVYHLLADLSCSSFLNNYSTTNQPLSHDGNFDDSPAENNPLASILLTLYDRFELCICLFFRDNNVEMLFQTICRVKSNYLIWSAVPYTASDICHAVQGEVKTVLYDYLITVEKTIASTNTVSSMNEILRDKRKPAERIGKQVFRINGASNSTLCVISENEDQDEIWKDADLAKCSVNDTLVGKGVVDKYANVLSNGHKPLIRPEASNILIAFKPTMQFTDSLEQAVGISPGVFHVFLEDFVLNVFLPQTHDLSVIALGYLLQSMCKMSNTIPIHKEEFLKSLEFILEKFHEKCLSRFRTLISTEQSGSENSGSISFAWTKNEKLTELMAENLFLTDAFDTPAQMNRNQAAWQKETDLEMKLKGERSFHRSELIFESRRLQGLAQLHYSMEWLAAQIMYMKGDTGSSTGLVATKVFENSVESLTEYVRLSSDSLPQLIVDSSELPQAEMTTEMANRFSVLANSFKALEKKCIYSLRVELRCHSMFLFDGLGELMAQVLIFNLRYIRTVNLNGVLRLVRNIQSLQQNLTNLACAHQESLDRAKTYYELLGLDVEAILKMIPKNSGQYTYDEYKAILDLKFHDAIVEGGAAIKPYEETIVKLKRYFIDHRN
The following text describes a protein:
Function:
Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators; Bifunctional enzyme. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid. Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates.
Subcellular Localization:
Cytoplasm. Peroxisome.
Domain:
The N-terminal domain has phosphatase activity. The C-terminal domain has epoxide hydrolase activity.
Sequence:
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
Subcellular Localization:
Cytoplasm.
Sequence:
MTRLDNSQFLKQVETLTQSNNGKSSIYLTQKRLSPSLSSITTTTTAEDESINDLPTNVITPTPKTTTTTTTINNDSKYPLLIRLSMNSSDNKIKTKTKTKTDSKVQKKKERVKISTVVELDQLNEFWDQYIQILKSGFYWIEKEER
The following text describes a protein:
Function:
Probable polyketide synthase.
Sequence:
MIENNIDISSKSYRDDCDVAIVGLGLRLPGNSNRTSELWDNLLNGFDGIVETNERWSDTFNAMGEIASKEAGLLELEEWMSFDPLHFGINPAEAKQIDPQQKLLLKTTWEAFEDAGIDPLTLRGTSTSVFVGASSQDYGIMYMDHSEELVNYNVFNSNLGGFANRISYCFDFRGTSLTVDTACSSSLNACTLAYKSIVNGDSDYSIVGGSNLILNPQISKAFTSINIIGKSGRCKAFDESADGFVRAEGVAVLILKKLSLAQADGDQIYAVIRGCNSNVDGTLNKGNFMKPSKTAQTNNIIKAFESTKGSLQYSDIDFFEVHGTGTPIGDPIEVEAVADVFKSVKTPDNPLLIGSIKSNIGHLEPASGVASLAKCCLMLKNRQFVKNIHFEKPNPNIKFEEWNVKVCTENTEFPNNKQVSVAINSFGITGSNVCILLSEYNNSVVPSKNNTKPTTILIPISANSKKSLDQLKDEIIGNSTLYSNTIDFKDFVYNQLYSKSTQLVQRSVFIVSNFSDLSLETSSISTNSTISGNILKSNVEDNEANDNSSKTPLIYVMCGQGPQWNGQAIELYNKEPIFKKSMDTIDSILSKYFGYSILSKLRSIKDNDNNTINEPTVAQPSIFMLQVSLYDLYKHWDIKPSIILGHSFGEVSAAYCSGMITLETACEIIYQRSTLQNKTIGSGKMLAIGLNEQQFKDQFSSKYPTIEISCYNSPSSIVICGNESEVNEIGQTLKEKQVFSTLLGSPSSFHSSKQEVIKDEIITLTKNIKSNKPNIPIFSTVTGEIFKSEDSQFDSNYIYNNIRQPVLFQKAIENIFKYIESNELGNRVQFLELSPHPTLVNYIKEMIPTTSDFYQPENISVLSSLNRKTNTDMIEIRKSISQLYCNGYNVNFKCQLPAPTTVEKLQSKKASYVLPRYKWDDDIYFHQSSSIQTYKMNGSTINTLGYKYDQTPFISYTSYIDVSQEPYKFLKGHQGKGKTLFPGCGYLDNILKSFPNQDITINILEFKSPLILIDGVRQCLSTNIYQSGKSEYRVLFHYKDIKTGKWILSAQGRFSISKHNKTPKNVDLNVCKNICNWITLPRKELYEAIKEMAQLNLTGSFQSIEEGKFGNNAAFIKIALNPLSSYDNQLFLNTCVLDACFQSLSVFKDHSSLTFFDRLMEVQFFSENIPRSAMDRDKLKYVYCYTELIDRVGDSYIAKVVMMLEDGTILFTSPAAVYTAINPNTNGYTIENPNHCFYSVAKQSKDSPLEPPSKTLSSKITEIIPTPANNILKAITTTLYTPVKKSYQAITPAGVTEDSTQLLISKYFKVSESDGTPKMNLAKLFFEMLKNNVSLIEYGASANLAKVVNAQDIKTINKLTKFLLNETPTPIDQASSTLITSFIPEIPHNQIIKEIITASITPIINEKIVFRILEVGSGIGLLSEIIATEINSLIEKNPLSEINIEFTTSDKENTFAPLIKEKLESIVESNLSSFKCLFNTIDFKQDLLDQNFYPSYYDIIIVSTFSDIEDKKSSVEKLNKILYPNGYLVIIDTLFKPKTTDKELETYGQWLSYNCLNSTTTIDEWKQLLVTELGFKDVISTTSQTSLITAQKPKLVESTLSMQLPIADYDQIIIFGLSIDGIDESKLISGINQATEKPDSLYRILSYEDFEKHIESKPLTNKSIIFFVSTINDIGQGNFVEITYDYIRINQHLLKTKNGCKHILVSKLSQLESINAFASSVIGAFRYFCEFSELNIYAFDFGFDIFEKSLTDFRIYNELSNPQKHIQREYIIRNESIYFERIKQDINLKLKYNSTSYIDKKEELIARLDAQNLEFKLEARRSLLENEIEVQVKAVGINFKDSLVYRGLVPKESTNRKGDHNNPEMGFECSGIVTRVGSNVKKLKVGDQVLGACFSAASSHVIDDEERFLLKPSNISFVEAASIPLVYITSYFSLFYQGNLSIDQNETVLIHSGTGGIGLACIELLKAMGFKSLLFVTVGSKEKEQFLRNTYGDFITGIYSSRNTDYMHQVRNKISEIRGKEKPVFSDLYFGEHGVDVILNTLPVEFMEANFNTLAQGGRIVDLSVTHLHPNETTDYSKFRFLISYSTSEIMSSGFKKSKPFFETVVNMIKEEKLSLLPIKEYPVSEIKQAIEFISERQHIGKLVVNFETTPDLIQDTIEKSHHGFEKNYLLPSLTYQVDNNRFGKTILLSGQKGLSLTIIKWILVNTPKNLDQAIKNIIVFSKSPIKFELEIIMAAAKSKNIPINFYFKQVDISLSLEVDQAIDQLYKDNPNLEPVESIFHNAFLPVQSEAEEINLQQLVDSHGAKIFGMMNLYQSVGSKGWLVKKFVLASSVTSIIGGHRQCGYVCANVVIDSFTKVLRQFGIPCVSINFSAIENSGYVSRNESVQALFSSQGLQQISTNLVLGSLDLITQNQDQLNGKIVAQFNYSNIGKTFKNNLHLYKIDFFLNSIQSKFGSSYDDDDEISIRDQIVDKFSEYLSVDKSKINMDVRLCDYGMDSIMVVELKNWLDKTYVPNILTIAQLQQVTINQLAAAVKNAVSKSNNKKTIKKKQQQTNSSIEWESEIKLDESFISPSQNQIKVYKETLATNKDNQIVLLTGATGFFGLYLLSDLVKSSDYKKVYCLTRNRSKEEALKTIIQLLKDHQIYKQLTQDQLDKIQPISGDYSKDMFGMSKEEYQLLSKEVTTVINSAADTNLKKKYRDMKESLDGVNQCLKFTIHYNLKKFIQISTVSVYANSTSTQTNDEYAFPSINKESMESVTMTGYNQSKLVAEYRIKEASSKGVPAMIIRCPPLFPNPETGIGRPFDLFQVLLQSCYLMDVYPQELMFQKMYTIPITWASRNISFIISNCWNFSTPIENLICFNLFGNSIQIGDIIQSLATDLTWRRLTSLQFIKKLSIYENDSCRLLASFVSNQQDFLRNIIVIPGQLNLNDQLKQILESNNLFNGWEVSKQNIITHLSYTFKKKIL
The following text describes a protein:
Function:
Trnascription factor that regulates the expression of the homocitrate synthase (HCS) lys4.
Subcellular Localization:
Nucleus.
Sequence:
MRSYSNPENGGQINDNINYSEKRPTMLPENLSLSNYDMDSFLGQFPSDNNMQLPHSTYEQHLQGEQQNPTNPNYFPPEFDENKVDWKQEKPKPDAPSFADNNSFDNVNSSKLTNPSPVQPNIVKSESEPANSKQNEVVEATSVEKAKENVAHESGTPESGGSTSAPKSKKQRLTADQLAYLLREFSKDTNPPPAIREKIGRELNIPERSVTIWFQNRRAKSKLISRRQEEERQRILREQRELDSLNQKVSQAFAHEVLSTSPTSPYVGGIAANRQYANTLLPKPTRKTGNFYMKSGPMQSSMEPCIAESDIPIRQSLSSTYYNSLSPNAVPVSSQRKYSASSYSAIPNAMSVSNQAFDVESPPSSYATPLTGIRMPQPESDLYSYPREVSPSSGGYRMFGHSKPSSYKASGPVRPPNMATGHMRTSSEPTSYDSEFYYFSCTLLVIGLWKRLRASPQDLMCFYSPPKKLFAYLIQFQGIQYRIEYSFFVIESIHVFRVEEPLLNELSATASSRDKPAPNEYWLQMDIQLSVPPVFHMITSEGQGNCTDFTEGNQASEVLLHSLMGRATSMFQMLDRVRRASPELGSVIRLQKGLNPHQFLDPQWANQLPRQPDSSVFDHQGRNPPIQGLSHDTSSEYGNKSQFKRLRSTSTPARQDLAQHLLPPKTNTEGLMHAQSVSPITQAMKSANVLEGSSTRLNSYEPSVSSAYPHHNLALNLDNTQFGELGTSNISYPLSAPSDVGSLPRASNSPSRPVMHPNTQGINTEIKDMAAQFPNSQTGGLTPNSWSMNTNVSVPFTTQNREFGGIGSSSISTTMNAPSQQLSQVPFGDVSLATENSVPSYGFEVPSEESVYAQARTNSSVSAGVAPRLFIQTPSIPLASSAGQDSNLIEKSSSGGVYASQPGASGYLSHDQSGSPFEDVYSPSAGIDFQKLRGQQFSPDMQ
The following text describes a protein:
Function:
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Sequence:
MSTDVKLNCDFILVFHKGLMLGIRERAASRQIQHMALVTANGSKPITESIAVALRRIVFGECPAPIKTEYFMRGPGLVFREAERDLGYALRVSHAAGLPITNSLMMAIQTHILRILLFDVRPVRVYQPDPLKPSFSMQQEALCTAITDIIWKAGGSQYGVLCLPHPTHTHVEESDLFNADGVTEKLNLLECHNREELQYFVRRNLFLFQQDPGPALILLIYSAVLSRRIEMQVSSHSSKHD
The following text describes a protein:
Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MTFRHLFRMLVAVAFTAIVNARMDECRFESGRPRRCLPPFVNAAFGRTVVADNTCGTPAEEYCLQTGVTGVTKSCHICDSSDPARRHDAQYLTDFNNEDVSTWWQSNTMLHDVQYPTMVNLTLNLTKAFDITYVRLKFHTSRPESFAIYKKKCDNCDWQPLQYYSGSCFTTYGLDNKGIVTGDNEQKALCTDDFSDISPLTGGNVAFSTLESRPSAYNFDRSLVLQDWVKAVAIRITLNRINTFGDEVFRDPKVLKSYYYAVSDLSIGGRCACNGHASECYLNAEDVLTCRCQHNTAGRDCERCADMFNDRPWARATRGDAAECRACDCNGLSETCYFDPELYRQTGHGGHCTECRDNTSGPHCEICLPYHYRDPFNNRCVPCQCNEIGSTSQQCDVSGQCACKPGVGGASCGQCMNGFFGLSEAGCSACRCSIAGSAEGSVCDAETGSCVCKLNVEGNNCDRCKPGSMNLQASNPFGCTSCFCYGHSSVCEVSNHYTVKYIASDFTIGTDGWEGKDFYANPSPVTKRNNAIAMLQPDPYYMSYFVAPAKYLGEQRFSYNQMLEFDLVLEEQPFDLDIGREDLVLEGAGFRVVASITDQGNPLPTSTRQTYQFRLHEAAGFHPQISALDFQKMLNQLTSINIRSTYGRGLNAYLDNVRLTSAERDGNGLPADWVESCEAVGYVGQFTESCDIGYTRDPSNGGEYDACVPCNCHGHSQTCDPTTGVCECEHNTMGTHCELCADGSTSGTPQECQPCPCPVGSACAMLDDGDVVCTSCPPGHAGKQCELCMDGWFGDPRGSGPCQRCMCNGNIDENAVMNCNRTTGECLKCIHNTTGFYCDACLPGYFGKPVTNVPEERCMICECDHLGSRHMSECNARTGQCNCLPNVEGRSCNQCRSGYWNLQSGNGCDACGCHSIGSSTGECHQETGQCACLPGVGGQRCDQCMPNYYGLSRQGCSECNCNPDGSVSLQCADDGRCLCKDGVLGVKCNQCQENYYDIANGCIECSACYGLVQDAVQIHRRELGKLESMTSNIGNHTNKDAQGNEDFEMALAHLNQTVHQLHDQAQQNAEHQAALQDMIDQVNSQLEQLYMKLAVIENSVETCAATVKQADDKNAASKNDTLGIAVALQSAQDKLDQAMDDLIASRMIAEDSLSKEDNMSRIAKEAEALANQHVIDSQAVVDTAQEAFDTSRRAQDAVQEAIDLLETLMSTLDDMIDSENKIPGARVTRNDLIAQSDRLKSNAEAAKNESTDLFTDAEKLVVPVVDTDDMISRSQTIRTEAQDLIPQINQLEMEYNNNYGTLVSDKHRARELLSVTDALQDSADMMLAQVHSSYQDALEAVESGNATYHSVLNTKKSLESFDEEINMNREKARIELNKTDSIQAKIDLANEKTNGAKAALGTARSIAVQASDKAQQALDIAGNIQISAQEIRTDAENSHDRAAVISSSVENLSDRLASTDLKLSNAENQAQTDQTNVNAATRAAGSAGKKATESKKRVNSVLSQLENLLDRLNAMVDVNDTEIAQLEQQYEELKNQVDSMNLPNTISAFNAEVNRHQRTLDAYDEEIVKLEADVQNLREINASIPETCSSNKKVEQP