lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters (By similarity). Required for early embryonic development.
Subcellular Localization:
Nucleus. Note=Concentrates in Cajal bodies tethered to histone gene clusters.
Domain:
The LisH domain is required for the activation of histone gene transcription.
Sequence:
MLLPSDVARLVLGYLQQENLTSTCQTFILESSNLKEYAEHCTDEGFIPACLLSLFGKNLTTILNEYVAMKAKETSNDVPTIMSSLWKKLDHTLSQIRSMHSSPGFAAHQRARTRNGIAEIKRQRWLASQAAPVSSELLVLPYASGQFTTSPLVATQAVKPTGPISTPVRSNIVVVNQSQPQSTVTNTAGESLNIIPGPQERKTQTSLMSPGRRKSESQKKSLTSSGPHSSRNFQDPNAFAVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDSSVAQVPKQTDSNPTEPETSIDELLGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNMPQISSQPMETNSNIVLPEETNLTIKSSFETEESDGQSGQPPFCTSYQNEDVLLNDLKSGNSHDVLPQESQENFSQISSNIQKKTFKTAIPAEQKCALDITLESVSNLSDFNQRGSSAECNEHCSELFASQIPTEAEVAVGEKNSLSADILSQSQYQPDQPSVPVTSFVSLGGETNDKNLVLSGKNSQLLSQSTPLTTKPSKSQLCENSNNIIKVKTNPQASESADSSETANRKTETNTVSPAAAQPQADCQDNSPLQSKPPPGIGESLGVNVTEKIEIHLEEPAPSDKQLSNDAASVDLNPTESKTEPLQSASAQEPEPPSVKDGDTIFLSLSEHNSCEEVALVLGEGNPVKNNNSLSSESGGSVGVSPETQNTDGKTSNSTEVDASSIVSLKIIISDDPFVSSDAELNSAVSSISGENLPTIILSSKSPAKNAEFVTCLSSEETASAVVSVEVGDSGSMEQNLLVLKPEEPMVNNTQNEDGIAFSANVAPCVPKDGGYIQLMPTTSTAFGNSSNILIATCMTDSTALGPTVSQSNVVVLPGSSAPMTAQPPQQQLQTPPKSNSAFAVSQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNTFSTPPQQVLHMPLAAPVCNRSIAQLPIPQKSQKAQGLRNKLITGKQVNNLTNLSSLSEACHTQRTEASDKNIATELGKKMEDTTISLSGERVAPPSKPFESHRRVLCFDSTVSSVANTQGSLYKMTSENKEKKEASFSHLDSPILSSTLKPPPNNAIKREREKTVPKILSKSETASSRHTTVKEVQSEKKVSPTEVALESLHKATANKENELCGDGERPKNADTSKLPGGQQNGSLRNEKAIASLQELTKKQATPSNNKNATSVGGTVKDQKQEQSKPASSLIGAEILQDVPIHSPANRSADTDLPVPRTPGSGAGEKHKEEPSDSMKAPASRRCGEEGSMPRVMIPPVTADLPACSPASETGSENSVSMAAHTLMILSRAAIARTTATPLKDNTQQFRTSSRSTTKKRKIEELDECERNSRTSGKNLANSSVPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE
The following text describes a protein:
Function:
Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.
Subcellular Localization:
Mitochondrion matrix, mitochondrion nucleoid. Nucleus.
Sequence:
MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGAALYVFSEFNRYLFNCGEGVQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLEKYLEAIKIFSGPLKGIELAVRPHSAPEYEDETMTVYQIPIHSEQRRGKHQPWQSPERPLSRLSPERSSDSESNENEPHLPHGVSQRRGVRDSSLVVAFICKLHLKRGNFLVLKAKEMGLPVGTAAIAPIIAAVKDGKSITHEGREILAEELCTPPDPGAAFVVVECPDESFIQPICENATFQRYQGKADAPVALVVHMAPESVLVDSRYQQWMERFGPDTQHLVLNENCASVHNLRSHKIQTQLNLIHPDIFPLLTSFPCKKEGPTLSVPMVQGECLLKYQLRPRREWQRDAIITCNPEEFIVEALQLPNFQQSVQEYRRSVQDVPAPAEKRSQYPEIIFLGTGSAIPMKIRNVSATLVNISPDTSLLLDCGEGTFGQLCRHYGDQVDRVLGTLAAVFVSHLHADHHTGLLNILLQREQALASLGKPLHPLLVVAPSQLKAWLQQYHNQCQEVLHHISMIPAKCLQEGAEISSPAVERLISSLLRTCDLEEFQTCLVRHCKHAFGCALVHTSGWKVVYSGDTMPCEALVRMGKDATLLIHEATLEDGLEEEAVEKTHSTTSQAISVGMRMNAEFIMLNHFSQRYAKVPLFSPNFNEKVGVAFDHMKVCFGDFPTMPKLIPPLKALFAGDIEEMEERREKRELRQVRAALLSGELAGGLEDGEPQQKRAHTEEPQAKKVRAQ
The following text describes a protein:
Function:
Regulatory part that prevents formation of the Nlrp1a inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of Nlrp1a (NACHT, LRR and PYD domains-containing protein 1a, C-terminus), preventing activation of the Nlrp1a inflammasome. In response to pathogen-associated signals, this part is ubiquitinated by the N-end rule pathway and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the Nlrp1a inflammasome.
Subcellular Localization:
Basolateral cell membrane. Cell membrane; Lipid-anchor. Inflammasome. Mitochondrion.
Sequence:
MCSQEDFQAQRSQLVALLVSGSLEGFESILDWLLSWDVLSREDYEGLSLPGQPLSHSARRLLDTVCNKGVWGCQKLFEAVQEAQANSHTFELQGCWDVHSLHPTRDLQSHRPAIVRRLCSHVEAILELARDEGFLSQYECEEIRLPIFTSSQRARRLLDLAAVKANGLAAFLLQHVRKLPASLSLPYEGYSLCGSHCDHRLNLIRLFCILAAECQKFTAKLRTMVSAQSRFLSTYDGSENLCLEDIYTENTLELRTEVGTAGALQKSPATLGLEELFGTHGHLNKDADTILVVGEAGSGKSTLLQRLHLLWASGQNFREFLFIFPFSCRQLQCMTKPLSLRTLLFEHCCWPDVGQDDVFQFLLDHPDRVLLTFDGLDEFKFRFTDRERHCSPLDPTSVQTLLFNLLQGNLLKNACKVLTSRPDAVSALLRKFVRTECHLKGFSEEGIKLYLRKHHREPGVADRLIHLIQATSALHGLCHLPVFSWMVSRCHRELLLQNRGFPTTSTDMYLLILQHFLLHASPPDSFPLGLGPGLLQSRLSTLLHLGHLALQGLAMSCYVFSAQQLQAAQVDSEDISLGFLVRAQSVVPGSKAPLEFLHITFQCFFAAFYLAVSADTSAASLKHLFSCGRPGNSLLLRLLPNLCIQGSRVKGGQAALLQKAEPHNLQITAAFLAGLLSQQHRDLLAACQVPERVLLQRQARARSCLAHSLREHFHSIPPAVPGETKSMHAMPGFIWLIRSLYEMQEVQLAREAVRRLDIGHLKLTFCRVGPAECAALAFVLQHLQRPVALQLDHNSVGDVGVEQLLPCLGVCTALYLRDNNISDRGARTLVECALRCEQLQKLALFNNKLTDGCASSVAKLLAHKQNFLSLRVGNNHITAAGAEVLAQGLKSNTSLQFLGFWGNSVGDKGSQALAEVVADHQRLKWLSLVGNNIGSVGAHALALMLEKNKSLEELCLEENHICDEGVYSLAEGLKRNSTLKFLKLSNNGITYRGAEALLQALNRNSTVLEVWLRGNTFSPEEAQTLSSSDARLLL
The following text describes a protein:
Function:
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MYHLFWLKNGELIQDKSTRYENFVITSEHSLIISNVRFEDGGNYSCGAQNLAGKRISESASLVVVVNGNWSAWSQWSDCKCVRERGQMTRKRVRVCNNPPPQNGGLPCPDEPTQKSICGPCTVQWSLWSSWSACDIHCLQHRQRSCEYSLADNTGSTGLSGISVNRCNGDDQESVKCLDEPTCSDGEGPIQELEKIPNDNYKIYVGISLAILVIVVIVVCGFVGFKRIRKNFRVSNLLLKPETSKTILVMSANNNNNLTNNNNNNLTYNNNTFNSQQQQQQQQHNISPSCSMQSNNTESSTINDSSHYCDVNNLLPDNHNNNNIDRNYNIVDDCCYNNNINNNSTSQYAKYTQLNNLERSFMLPKYVSANVCTDALSWLSLDEHGGTICISGSNISLTIPEGALACGEVVEFFIGVSRDDKDRPHLNESQTVLSDILISGPTDVQLLKPAILSFPHCANNNNNHNNNNNNNTHNNNDNIYNINNNMNNNNIYDTIICDSGNDNFDDCNGNLNKIFNNNNNNNNNNVMNNNINLNNTNNISVFNNNCNNNSTNVNHKLVNNINNNNNNNTNNNKNNNNTNWLHYVTHSSLDYKGRPGYKQICTVGRETINTPVYVHLDATDCHIMTEQLGQFVLIGEPTGLAVKRIRLAAFAPKISPSMEYNIRVYFVEDTPDALKEIPFKHIWNDHPTALHCSFTLELVDRTQISLMCDIQIFQTGNLANARVLNIAQCVADSMASSYSHLSLARPKTINNNSNVSHVSSYNNNNNNTNINNISNNNNNDDVIEKIGDGNDEYNGRYGFPFFRLPINLRRQLCHILDVPNCRMNDWRKLAQLLKQDRYINYFATKLSPTDHILSLWEARTNNNIININNNINNNNNNNNNYNNSNNFIINVNDEEDDDDNVFNNNNNNNNNTNNINYHNNNSSSVIYSRNHNNNSNNNNNSNNNNNNLKYVEELVECFRCMERPDILNVFEQQRFDI
The following text describes a protein:
Function:
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSAIALGMIIFAYLCGSISSAILVCRVARLPDPRTHGSGNPGATNVLRIGGRTAAVAVLLFDILKGMLPVWIAYLLHIPPLYLGLTAIAACLGHIYPVFFHFKGGKGVATAFGAIAPIGWDLTGLMTGTWLLTVLLSGYSSLGAIVSALIAPFYVWWFKPQFTFPVAMLSCLILMRHHDNIQRLWRGKEGKIWDKLRKKKQKTPAEEAAELEEKED
The following text describes a protein:
Function:
Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere. Sarcoplasmic reticulum.
Sequence:
MGQRTEWVEPAGLGGASGVSGGAGCGRCRGRRCPGDGRSPSRQCWWPPPLPEPERPPLLPRVAASQGGGMLGKGVVGGGGGTKAPKPSFVSYVRPEEIHTNEKEVTEKEVTLHLLPGEQLLCEASTVLKYVQEDSCQRGIYGKLVCTDFKIAFLGDDESALDNDETQFKNKVIGENDITLHCVDQIYGVFDEKKKTLFGQLKKYPEKLIIHCKDLRVFHFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYAAAARNSTATHPKNHTVMFETLQDWCWELERTKGNMKYKAVRVNEGYQVSERLPEYFVVPTPLPEEDVPRFQGHGIPMWCWSCHNGCALLKMSALPKEQDDAVLQVQKSFLDGVYKTIHRPPYEIVKTEDLSSSFLSLQDIQTAHSKFKQLFLIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECLEAQNMNVLLLEENASDLCCLISSLVQVMMDPHCRTRVGFQSLVQKEWIMGGHCFLDRCNHLRQSDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGRESQDIQGKPLNLLTVWDWSVQFEPKAQTLLKNPLYVEKPKLDKGQRKGMRFKHQRQLSLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDELQDNFREFYDSWHSKPTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGRVATMSKLLEMMEEVQSLQEKIDERHHGQVALQAEASSLLRASARLSSLFPFALLQRHSSKPVLPTSGWKALGDEEDLAKREDESVDLGDL
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Subcellular Localization:
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Domain:
Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
Sequence:
MQASIESTGNLERRLTFTLPQERLETHVGGRLRELARTTRIKGFRPGKVPTKVIEQRFGQQVRAEAMEGLLRETFDSAVREHSLRLAGNPRIDQGESDFDFVATFEVVPDFGDIDVTNLSVVRHTAEVTDADIDQMIENLRLQRRTWNPVERGAQVGDLVALETWSQAGNERLPAEGVETGSSVLGSGVMFDQIEKGLEGLSKGEDKALSIDFPADWRVPQLAGKTVQVHVKAVEVSEPVLPEVNKEFIKSFGVKSGDAEQFRADIRTNLERELKGALMNRLRREVGEQLIAAYAHVEMPPRLVENEAGSMLAQQVDQMRRSGRNPGEIPADAHQGFMDAAAKRVLVGLLVGEVARRNELRLESKRVSETLRLIASTYEEPEQVIEMYRNDPQLMSGLQSRVMEEQVIDWIAERAKHTEQSLSFQDAIRV
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Sequence:
MASPVSVVDLKEDALCPLCKQYLTDPVLVDCDHNFCRICISDYYVSKKEKNEPLQCPVCSSPIQEGKLRPNQQLGSIVEKLKKLPALKVGKDYVCPKHKEKLNLFCEDDEELVCLICERSPEHASHTVHLAEQAVEKYKIQMRVRLVKLKQLKEEMGTIPRDAEKETFDMLKMVEKEKEKAAAEFKNFHGFLDEQQNLLLTQMQELQKEVARKRKHYVSSLSEEMTSLTKLIAEIQETCEQPATEFLMDFKQNFQRCDTACQDSVSFPLELKWKLWEFCDTNLLLDAISRRYRDALISGLKSQEEKITLEPSTAHPQLILSEGNRSVRMGEIYKKFPRSPERFDEWPFVLGYEGFTEGRHFWEVTVGNEDTWGIGVAKNSVQRKGDINFSPEGGFWAVGKWEGNYTAYNPPFYTLMTLHKEPKRIRVFLNCDGGWVSFFDADTASPLFSYSAASFFGETLFPFFYVFGKARLSLVTSES
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDHLSGYARRPFAFVLRYLRRRLASHLVILTAVVAAVACSVGTQYGVKSLVDSLSAGTAHGGSVWLAFILLMSLIAADNFLWRIASWTASFTFVRVTGDLRRDIFRHLTGHAPSYFSDRMPGMLTSRITATSNAVFTVENMFVWNVLPPCIATIAAIMLIGTVSPYMALGLIVVAGGMVIAMFHLAAAGKPLHDDFADKAAVVDGEMIDVISNMPLVRAFCGISHEHERFDATVNRELTARGRSLRYLEKLRLTHAGVTVVLTIALMAWAITLWQDGEATTGDVVLVCTLGLSILNATRDLAVALVDVTQHVARLTEAIATLLVPHDLRDHPEAEPLVKSGAAIAFNNVTFGYPGGEKIFERFSLRLQPGQRVGLVGQSGGGKSTLFTLLQRFYDVDEGSVTVDGQDIAMVTQLSLREAISVVPQDISLFHRSIRENIRYGRPNATDDEVLRAAIAARCDFIDSLPEGLDTMVGDRGVKMSGGQRQRIAIARAFLKDAPILLLDEATAALDSESEEAIREALTRLMRGRTVIAIAHRLATLRNFDRVIVLKGGKIIEDGSPERLMQGHGPYRELVTQEMSRLAQAAA
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MSYFYEEIPDLPLPELKNECPWLADRIHRLRSQCFHYWDHWTTKFSEKWKRSTTEEQQLIRVLRENVVEEKETVLPGFAYVAISWMTGTVLVRRRSLPVRWTVPPALGLIAFSYCFPKTYQKASNYVLQKSPTGRRAKEFVSEKETQMSETIKEYADRTKTTVQNVFDRKKPSS
The following text describes a protein:
Function:
Low affinity ammonium transporter of the plasma membrane. May be involved in drug resistance through pumping them out of the cell (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSTSSSVTQKNLDTNAEALKKEDKVLSEFDIQDERPKSLLWESAFVGVLCSAQLMTQAGLGQSLAPLHIIGNSFGTTNAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHTPMPSRDASSFKLLERIDFAGSVTGVVGLILFNFAWNQGPVVGWQTPYTYALLIVGTFFLVIFAYIESRAAFPLLPFAALSSDTAFVLSCIAAGWASFGIWIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFCAAVTTGFLLSHTPPSTVMLFAMTAFTVGTILIATAPVHQTYWAQTFVSIIVMPWGMDMSFPAATIMLSDSMPHEHQGLAASLVNTVVNYSISIGLGIAGTIESRVNDGGAKPLKGYRCSWYMGIGLSGLGIFVAATYAWSTFMKSKKRISEKQHFIE
The following text describes a protein:
Function:
Transcription termination factor required for mitochondrial NAD2 intron 3 splicing and normal membrane respiratory chain Complex I activity. Essential for normal plant growth and development. Binds to RNA but not to double-stranded DNA.
Subcellular Localization:
Mitochondrion.
Sequence:
MASKLKTFINLRDYPITLFNQIRSLSSRILTPINQSHYRKRILLANLLQRYGFPPSSLQHFLSRNNHLLNSDLVETEISLGILLSLKIPQKSLVSLISDCPNVLRSEFLRKWRVPLSNCGKHGVVSSSAIKSVLEHSSRIGIGPDKFNECVRVLKSLGFCDSTVSRILSSFPGVLLVNEIEIRRKIEFLVGIGIARDNIERFFHVFPEVLGIGTETRLKPLLDEFMKMGFSKDDVKKEIAREPRVLGLELGELPRCLELINTLKCREVIRVSIISEGAFRAGFEVKLRVDCLCKYGLIRRDAFKVVWKEPRVILYEIEDIEKKIEFLTNRMGFHINCLADVPEYLGVNLQKQIVPRYNVIDYLKLKGGLGCDIGLKGLIKPSMKRFYNLYVMPYPECERIFGKRKENVRVNKRHPAGLWKLMKPPSNLTTKEDVQNMKSFIESLA
The following text describes a protein:
Function:
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Subcellular Localization:
Chromosome.
Sequence:
MGDIHGRPEPAARTESLVESLIRQTLLGETGEEPGSQGTLLGDMPPGSVEKAIHLDRVILNAGRKFSGSLTRGESENSTRDAPELGNSSHGTTGKFPKVARKSNSAQEVRRAHRSKPASSKKARDVNKGGMEVCPLPTDPGISQLEGGQVAATVGRDAALSPGQQPVKQEISPASSDDITGSSPDSESTRSVTSPRSEDSSLTTNQGSSNGVCSPVLSAPRKKRKRCGACEPCTRKENCGECSSCKNRKTGHQICKLRKCTELKKKVGTTSSGMEQRTKKAQTKTDWTTELPGQGIPSPFADQIKTNHLAPHHPAFYPNGECQYDQERLHRNLPAQRFEMLNHSVPSSFEPCHSPNYAREEVHAGERRRSHGGLADALSNAPQESRNSHVHPKFMKMSADGALVRKAADLHTVSAMEASQSKMDGERQPNAVEQAASGIMLLHALTSRMSENAQKDEFQQQQQQVVQNHNKQAVHPSAIPPQTAKTTLPAHAARDHQKETPPNSFKDVLDPQQYHHGSQSQSLNNSTHSQRTPDAARAFTPSGFFQLQEVLKAPPPFEWPGTLESAKPRTISKTHPGHHADHPNKSGMPGRGEPFGMPEKSDTSRRAGKSETSAKSRTVASASEPPRKSGSLGSSDVALEAQRAPGLSRLLESPSSCITTSGLPVPPRTPEKSGKAGASGRTKTLDNLLMSTQQLQQMFDNLPYIPQSEPGPSSQQQPPTTPQSTPTTPRASQETPRTPQSTPLTPQRTPHKTAGAHTTKSDCKFELPTCNCVDFVSEKAEGPYYTHLGTGPTIQAIRELMEKRFGQSGKALRIEKIIYTGKEGKSSQGCPIAKWIVRRSSEEEKVLTLVRHRPGHRCNSSYIIICIVAWEGIQRARADELYDYLSGTLSKAGLPTTRRCGVNDTKTCACQGVDDNNCGASFSFGCSWSMYYNGCKFARSRVPKKFKLEDPSEKYLSKEMRAREEAIIEDHFQRLAGEVGPVYEQLAPDAFRNQTEYSEVASDCRLGFGPDNTRPFSGVTACVDFCAHAHRDQHNMNNGSTIVCTLTCPENRKLGPPPEDEQLHVLPLYKMAPTDEFDSEEGQEEKVRTGALEMLTSYTHQIRISSKPKTPKKGRKQKDNSASSSNNNNAESPATEKSKEKVESKVPEIVPQQSQHAASPAFNHSMKQMAAGVNGAMRDPPAVNRKLFAHSQAGNPQSMDKSRPFSHPMHSEPSFQTKKPESKELDRMTQRQPLHGSPELGHHQFARHEAVKRPASASCDGPAAKQAAHHHAREDNPFMKAWAENLPRDAAVQQSSSGNPTTAKDPGIPSWQTEIGLRPIVQNGLGLQQPWFPFAPFHHVQHPFQLVQPAVGPFNQAANQPHAAAQTTSWQDPFESARFEKLFAGLDMFQRGRPNVEQNGGLQVQQQQPLKPDLDAAREATTPLPGPNTPAPSPHSYKGAFQANLPPTNANSKVTPLQGDRHLFAPGKEPGSKHVAPTSVLPMGYGLPTPPPPPYPHGDKTNQFPQTNPPPPPSMNGHRVHSPFIPNIGSERHISKVQLPQANSQEAQSRPQSARSLNGAQSPQVHQQSHYQLPSIQSIFRDSGLTLPTEARDQSMFQEGLAGRRFTDVAKNSFRPQTPTEQRPPSRKSHVPVQQPLAPNVAANLNMPLQFPAKQPPPILDDPYAFEPQQTSSNQPDRSPMPLNLSRPNPVQVQPPRIEENDILGNTAYPPALNGLRSQLLQKLNAAMKPDKDGVVRIKQEPMVCDSDLTDHLPPPYALHRKEDDEVWSDSEVCFQDEDIGGVAIALSHGSVLIECAKRELHATTAIKKPNRACPTRISLVFYQHKNMNYSRHGFAEYEQKMAAKAAEQEEARKHAEGGRKVESSIVKEAVAEESTKKVAEKTGPTKPAINNALTMTTDTVVTLWSVAVPQVTGPYQKWV
The following text describes a protein:
Function:
Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.
Subcellular Localization:
Cytoplasm.
Sequence:
MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLRAVELFHCYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPHKSAQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFPARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVKIDLATWNFQFLPQVNGHPDPFDEIILSSLPPALDWDSVHVPGPHAMTIQELVDYVNTRQKRGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSMAVGNLGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEREGMVPSGHSLLAMDGQ
The following text describes a protein:
Function:
Essential for fertility (male and female gametophyte functions and development). Required for the integrity of female gametic mitochondria (By similarity). Involved in embryo apical-basal patterning, and particularly dorsal-ventral patterning, during early embryogenesis, and endosperm free nucleus positioning and development as well as early endosperm development, probably by modulating the expression pattern of related genes (e.g. AL1, MYB3/AL2, CYP78A13/GE, PNH1, HAZ1, MPK6 and OSH1). Has function in triggering of endosperm programmed cell death (PCD) leading to syncytial endosperm cellularization and starchy endosperm cell maturation. Implicated in central vacuole dynamics necessary for microspore development leading to pollen production, and for pollen development and germination.
Subcellular Localization:
Mitochondrion.
Sequence:
MLALRKTLLHGRLPAAPPAAAAAAIASRIPALLRRLSSSPGDGQGGDEWGSSWSTGITKEHFDGSDAAVGRPVTSPSKPVSPELAAVRAMDEEDEIFRAMERDNREAKAYVDSWGDRMRETCELLKQVREPGSRGSYLKDSEKQEMYRLHKEDPETYTVERLAKDFRVMRQRVHAILWLKEMEEEEERKLGKPLDDSVEVLLDSCPEFFNSHDREFHVASLPYKPDFKVMPEGWDGTTRDPDEVLYEISMKEDQMLYEEFVQRLQFNKKKVAGEVKCHKYSRRRPDDGWTYMVEKLGAQSKRGSGGGWKFASLPDGSSRPLNDMEKMYVKRETPKRRRRIMAPFK
The following text describes a protein:
Function:
Promotes DNA damage repair through both homologous recombination repair (HRR) and post-replication repair (PRR) mechanisms. Enhances the retention of DNA damage response protein RAD18 at sites of DNA damage. This allows for HRR via association of RAD18 with RAD51C and for PRR via RAD18-mediated promotion of PCNA monoubiquitination.
Miscellaneous:
MISCELLANEOUS: Treatment of cells with ATR inhibitor Berzosertib abolishes the interaction of DDUP with H2AX, RAD18 and RAD51C and inhibits formation of DDUP foci, leading to hypersensitivity of cancer cells to DNA-damaging chemotherapeutics.
Subcellular Localization:
Nucleus. Chromosome. Note=Forms DNA damage-induced foci.
Sequence:
MWLVECTGRDLTGLSCLLSMDRQPRRRQHVAGCRDVPPPLPQGSWGQTSPRHSILCSKSGCDLLGGGEYNGETSGEEFLAPAWTCRAQQAATWLSVQQTSHKALGPAGGAAMSSKLSPEEQFLSRIHFLRTFMCSVAGAELPGIPQATENGEGCRPARDPASSPSSLSMASVYTQCSSAQLVSALS
The following text describes a protein:
Function:
Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation.
Sequence:
MPSKKKDYDLVEDGYDSRIPLHNEEAFQHGIIFQAKYIGTLDVPRPSSRVEIVAAMRRIRYEFKAKAIKKKKVNITISVDGVKCALRKKKKHLLKKQWTWDESKLLLMSHPIYRIFYVSHDSQDLKIFSYICRDGPNNVFKCNVFKANKKSQAMRIVRTIGQAFEVCHKLSLLHAAAQGDGQADGESDKAEEHSPGHRTVDGSNAVDEDEHVGETDIDAEEILTTDYATPASRGVTDLDKHFEARKVCGENLFSVSPSVCLSNSPVQIYEFFLPEEGATLSSPLHTPYMNLPQGAGDSQVSSTPLSMHHQVQLLQQQLQQQQQQTQVAIAQVHLLKDQLAAETAARIEAQARTHQLLLQNRDLLQHVGTLVANVQDLETQLTGQSYSETIPPLSTPHPSNDPPLPDTNTPAPGVVILPEFQDVEDAQQGGISSHVPGMFENTSLGIQPLVKEHASKELLCDGDSSHVPSSPVKVGAKDESSFLLDLDSDSGINGNTSEVESDRKELSNESLISKPRPEPKKTVLHTSAGPDGKLKVLVPLPQEGSLDGSQEFNIAPKIDPPPKSKRSRNSLKTTQDLMVPEGELASEQQGAESAEANGSESESAISPSESSGFGSSQSKSPSFENDGNLNDLSSSPRKGQKLGLNEMKLHISFSDDENTELSEDSGVPRDRDSGGFRQTQTMESLGFEDFDPFN
The following text describes a protein:
Function:
Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division. Promotes physical and functional coordination of the PBP1B-LpoB and Tol machines, and regulates PBP1B activity in response to Tol energy state.
Subcellular Localization:
Periplasm. Note=Targeting to the Sec-translocase for transport across the inner membrane is SecB-dependent. Localizes to the septum concurrent with PBP1B-LpoB and Tol at the onset of constriction. Localization is dependent on divisome assembly and requires ongoing septal peptidoglycan synthesis.
Domain:
Contains an N-terminal coiled-coil domain and a C-terminal TPR domain, separated by a flexible linker. The N-terminal domain forms a stable trimer and controls the oligomeric status. The C-terminal domain, which can also trimerize, is involved in interaction with TolA.
Sequence:
MSSNFRHQLLSLSLLVGIAAPWAAFAQAPISSVGSGSVEDRVTQLERISNAHSQLLTQLQQQLSDNQSDIDSLRGQIQENQYQLNQVVERQKQILLQIDSLSSGGAAAQSTSGDQSGAAASTTPTADAGTANAGAPVKSGNANTDYNAAIALVQDKSRQDDAMVAFQNFIKNYPDSTYLPNANYWLGQLNYNKGKKDDAAYYFASVVKNYPKSPKAADAMFKVGVIMQDKGDTAKAKAVYQQVISKYPGTDGAKQAQKRLNAM
The following text describes a protein:
Function:
Histone-binding component of a NURF-like (nucleosome remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates.
Subcellular Localization:
Nucleus.
Sequence:
MAPPRGRSKRKHPSESGNSSIADSEDPSESTSSSRPRRSRLPKRYFDDGYSPPPTKKRAAQRETPSDAEEVEVKIEEISVRSTPASTPAPKSTSKARGRPKKNPTPPRRKSLKRQEEDIIYMDEDSEEEEESSDDEFMLNEDQVVQEEEEELNLTDIKIEKGLDEENKYCPWLDEDPASLPKLELPESSQDIPIPTASIMDAVEIYEILRSYHRTLRITPFTFEDFCAALISHNNSCIMAEVHMALLRNCLKSDDEEQTHYSVTETNNSVNIMIHHMDTLTYAEILRQYIEAYPFADASVRDAINVDNYPFVGYDAKLVVLLFMSYRFLYSSEFKKLVNNVGKFQNDENCRVCGKSSGRVVGCTQCEAAFHVECSHLKPFPEVLVCNICKKNSAVRGVLPPDEAVDREPLRSQPIGRDRYGRYYWFIVRRLVVQSLDETELYYYSTVPQLYQLLQKLDRTYYEKDLCDTIRLRIDEFLEQMALTVEMTSERREAALETMVKRQLIGYDFAEATTPQIYLHRDSMKRMASILRDCAQKGQVKQEVKLEEPVEGQSPVKCVQFVEDSILPESMIGIFDAKLINTFWSGGATQEELVEQFVDISDNFDAPSANLWRMGDEGNDQTFMTYYNYYSRNEMSESFLTRKKAADKKKYMASKFAQIDNFDWVVAKNRQFYGDASLHCKFIMWTLQQVIKNIPIDLMHRKWPEFAKGFDLEVSVADDYKKLVTCLLKLDCAVRKTIFMPQWWNGLGQTRLERITVDQRENFMKEQQRLKKIDADALTKDLDDSFVRVNYMKPKWPNTYILRQRGETYRNAGKGSMGGWAWVAAKYVEKWIQVPESPKLPLAVTVEEIKTESVSNRKARRLELLVSKITKKRQRSGGKSSKKPTFELTNGCYSPSCRSNPNRKCYSPMCRNGYLVSAKQAHDERKLEESGVLGEEKAWPIPEIQTFSTKRGGKSIFVLQKKILRQMIMGGGCQQVYMPGFSAGIKSNLLIWPYPAPRPTLDLCWKWQTLNARSLHAVALQLKIIWSSIKFNEFDPDDTHPDRRVVIDTPSHDERRRIIRHKEMPPYGQYERYEMEIEIIPLYDEPEEEDESWLSRNRGGSSEFSHRSSSARKKRPQRSLDNRRATAIRREWVDGVTLKVFEIKDYWKWIRAEAEKTAKRKLEATRKAQKAKEDEERRRIQQQQQRSVARIPVPMHSLIPSERNNVPYLGSQQQRRPNGNERGFLEKYNNSSSVSPQAHGYASTPPPGYHQPQPNIIRQAGYNQLPRKPTTSPFNFQSRPVATIPTTPQLRAAAGADGVVRAVMMTPGNKSTVNTNSTPYPQALNRQQYQLQRQQQQPAVRRLTNGYHFMDGTMRGGGRNPSVQMHQRLPQNRAALQRPFGESTTEMRRVTEAAIPDNDGDEQPPVIPRYDPTSNFDAQRAQQQHPQSRPVYSTPAQMIRTTQPGGVKHNVILMKASDGTQKMVLKPGQFPPGTVISTGQRVVPYRQPTAVQQRQLYTATPGTRVVRIPNANGGAPRQQDHQVMRRVVQASGPRAMEYMDDQGTPPPGQQVRYVLQGGNSGTPNVNPPKVSSRGGPRGGLTMQMVQQQQQHNPEHRRLLAGRQKQKVTTYRDFMASRGYLDTSKFMMQTKPTFLPFEFNEEEEREINEAIAREEAWMRQEEENKTSGYDSSGNPIRSITSSGDTQRAPPYVSNLLPSSNDSPDDKVIKQVLDVMFSQVCRWDRQYGWSKTHVKRARQKNDSDKMHLRKFRMNQRELLITDHMERLKKEINKRRTRMENEAEQQCGLLTPWRKARARPHRAAKPKAEVKKEVINPADITLGGDTYDYVKEQKPTESIATNVSRRRRTSANLSKSEDDRDKPESQSTAPKSKERRTSEPPASHVAFHTPGSATPHDINLSIEHCTCQKIFDASKLYIQCELCARWYHGDCVGVAEQTILGLEHWSCEECIEEQERVKDQPALYCVCQKPYDDTKFYVGCDSCQGWFHPECVGTTRAEAEQAADYNCPACTREAEGYESEASDVSGSSRVSVQLTRADYTHVFELLELLLEHRMSTPFRNPVDLNEFPDYEKFIKKPMDLSTITKKVERTEYLYLSQFVNDVNQMFENAKTYNPKGNAVFKCAETMQEVFDKKLIDVREQMTARQQMLLLATAQQQDPMSSIRKRVQSESQRTVDSLDIDSDQLLPLDANLMRLYDF
The following text describes a protein:
Function:
Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries (By similarity). Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries (By similarity). Protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. Binds chylomicrons and phospholipid particles that contain APOA5. Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL (By similarity).
Subcellular Localization:
Apical cell membrane; Lipid-anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI-anchor. Cell membrane; Lipid-anchor, GPI-anchor.
Domain:
The N-terminal acidic region is intrinsically disordered. This region contributes to LPL binding, stabilizes LPL and protects LPL against loss of activity.
Sequence:
MKALGAVLLALLLFGRPGRGQTQQEEEEEDEDHGPDDYDEEDEDEVEEEETNRLPGGRSRVLLRCYTCKSLPRDERCNLTQNCSHGQTCTTLIAHGNTESGLLTTHSTWCTDSCQPITKTVEGTQVTMTCCQSSLCNVPPWQSSRVQDPTGKGAGGPRGSSETVGAALLLNLLAGLGAMGARRP