lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MNQNKGFYITTPIYYVNDIPHIGHAYTTIAADILARYMRLKGRKVFFLTGTDEHGQKVERAALQKGKTPKEHADIMVENFKTLWKGLNISNDAFIRTTDEEHKRIVQEILQRLYDKGEIVKRKYSGMYCTPCERFWTEKDLVEGKCPDCGRDVEFIEEENYFFLMSKYQQALIEHIEKNPSYILPETRKNEVLGFLKNRTLGDLCISRPKHRLEWGIILPFDENYTTYVWFDALVNYYSALKYLAPENVEWWPPDHHLIGKDILTTHAVYWSTMLMALELPLPRNIFAHGWWTVKGKKMSKSLGNVVNPSEVIKKYGVDAFRYFLFREVSFGLDGDFSEEALIRRINNDLANDFGNLLNRFLVMNEKYMKGAVKINSIIPRSEATRNLYSDNEFLSSFKSLIEEINNEILWDEFKFNIILEKIWQAISLTNNYIAKTEPWKVLKEEPERLPLILFNIWNAIRIITVFLYPFMPETANKIWYALGLRDYIIDYKMLKWELDIKEVKTEKIEQLFPKIEIKTEEQMKVEKREEAKVEDLISIEDFMKIKLKVGKVLQAERVKGSKKLIKLIVDIGEERQIVAGIGEQYSPEELIGRSIVVLSNLKPAKLMGVESQGMLLAATGEDGKISILTIDREVNAGAGIK
The following text describes a protein:
Function:
Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.
Subcellular Localization:
Nucleus speckle.
Sequence:
MSWQNNWSAMPPPAMNPQYPPPLPTTHTMPPAVPLPGYGAVNTEQYNQWQWQQYQQQYAQWYAMYGEKYAQQTGNALPPVAAPMPQSVPNVLANPYVAAPLPVGPAFGSMSMVAPPPPSEPHPDELRMGRITEKPPPPEEKSPEEIAFDEQFRKWEQEFETWKRTNINHPDKAAYREYEQKYEEQRKKLLDHREQLRRRKRAHSAPSQPLHSSALSISLQKPPPPPPQPAQPPPQPPSEPPQPSQPPRPPGQEPTNCSSNTTPTSTGGMAEENTHQAGSDAANSMHLHNLFSSPSKAGRDGGIPGLDLIDETPQPVPKKAKLDENVIDLSNEEEESKEPKPKETKPSPDNMISTLLNDPNVNALLQLVGKTISANGAGGSASGANAPNPLVAALAQLTSNTNAATLEPSMPNERPANGMVERNEPHPNASRFNGSKEQPPSTMQSGGGTPEECPTAGFRNRPQGFNPYVPPPLVDVDLSRPPPMLLPPGNSRPQRDRSSRNSDATSENGSFNDGYSGDGSPLPKIPRFDRPPPTFAANHPEYEIDPELGRPVAVPKPQWMTEEEYQEIYDRYEHVQSFDERKNKMLLAIQVLKTSKLRAGMLLEPPPDEVNRVPVAMPKPLPPVKTPIKSEPVDDYFQPQQVFDYSNCRNTRPVASQQLPTGRVIDYGHRGVNQYTANNNRLNSNSRRDEFRGMNNNARGGANENGFGTNTQRFDYNHSRVANAPPTTAPLQQNQQWPLSNQSAAQDRSVTGLERLAQMHLNPNPEESNPNYPSKFLLMNDNRPNCLSTKRGKRPSSIRKQKLKQLQQQQQQQQEQQQQLDQQQQPQQQPEPKAGQPEPEPAPSEAMPTPIVCKQEPEMHLEDLSSDEDGLPDGDDGFAYQSNDECVKPAIKQELLDDRPESPVSSLSSQNLSPIQMIDIEDLLLPPGRYQRPLRICFLIRGLPGSGKSHLARLIKNKEQSFGQSPRVLSLDDYFLVDKEEEEKDPVTGRITKLTRSVYEFDAEMEDVYVQNLLKAFKRTISERLFDFVIVDCCNHRLETYCEFHNYARSNGFKVYTCTMQTDVEDCARQNIHNRTEAEIQAYADNWAMAPDDHVQINFNSLLEPELQEETDTMVADMELVGADEEEPYGVDDQGLLEQISTSHDDSNDSFADGTAECDLFASKWDHDASEQNLARLDGTSKPLKRPPTLEDYLQLDDGNADEQQEDECQDGFSKSGGKKKRVRWADVEERKAQEKMRQLGFVVGVTDWRRMMDPSEGSSALTQTKYIERVKKQS
The following text describes a protein:
Function:
Overexpression results in inhibition of sporulation initiation. This sporulation deficiency could be the result of hydrolysis by PepF of the PhrA peptide, a phosphatase regulator. Thus, overexpression of PepF appears to act at the level of the phosphorelay, most likely through modulation of the negative role played by phosphatases. Overexpression of PepF also affects the activity of the competence and sporulation stimulating factor PhrC.
Subcellular Localization:
Cytoplasm.
Sequence:
MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLRNSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAVKELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGLNDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVLSEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESENREVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEEVYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYMLKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNNLFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQRLYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDGMVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAGSSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS
The following text describes a protein:
Function:
May play a specific role in the development of tissues.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Cortical cytoskeleton.
Sequence:
MGGKLSKKKKGYSVNDEKAKDKDKKAEGAATEEEETPKEAEDAQQTTETTEVKENNKEEKVEKDAQVSANKTEEKEGEKEKTVTQEEAQKAEPEKSEAVVDAKVEPQKNNEQAPKQEEPAAASAPAASSEAPKTSEPSSDAKASQPSEATAPSKADDKSKEEGEAKKTEAPATPAAQETKSEVAPASDSKPSSSEAAPSSKETVAATAAPSSTAKASDPSAPPEEAKPSEAPATNSDQTIAVQD
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction through the multistep His-to-Asp phosphorelay. Functions as a positive regulator of the cytokinin signaling pathway. May play a regulatory role in salt and drought tolerance during plant development.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MAAAKSNQLSTLVANMFTAGLLDDQFRQLEMLQDEGNPDFVAKVVMLFCEEGEHIIGELTKQFLCFCRDQPCVDYGKVDTFVDQLWGNSAYVGAQRVKNTCIQFHACCQEKSKVGCLKTLDSLRNDFYDVCSMFIP
The following text describes a protein:
Function:
Mediates the hydrolysis of some nucleoside diphosphate derivatives. Its substrate specificity is unclear. In vitro, it can use NTP, dNTP, 8-oxo-GTP, 8-oxo-dGTP, dGTP, dATP, dTTP or dihydroneopterin triphosphate (DHNTP) as substrate. Has some NADH pyrophosphatase activity in vitro; however, such activity may not be relevant in vivo due to the high concentration of manganese used during the experiments. Plays an important role in protection against oxidative DNA and RNA damage by removing oxidatively damaged form of guanine.
Miscellaneous:
MISCELLANEOUS: Has the ability to complement a mutation of mutT in E.coli and thereby completely suppress the increased frequency of spontaneous mutations.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTGEAIPRVAVVVFILNGNSILLGRRRSSIGNSTFALPGGHLEFGESFEECAAREVMEETGLKIEKMKLLTVTNNVFKEAPTPSHYVSVSIRAVLVDPSQEPKNMEPEKCEGWDWYDWENLPKPLFWPLEKLFGSGFNPFTHGGGD
The following text describes a protein:
Function:
Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.
Subcellular Localization:
Nucleus.
Sequence:
MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRGGSSDDRQIVDTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQRQRELERQKEIEEREKRRKDRHEASGFSRRPDPDSDEDEDYERERRKRSMGGAAIAPPTSLVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEPDRPRSPTGPSNSFLANMGGTVAHKIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIVGDATEKGESQDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEECEKYGKVGKCVIFEIPVLTNCHFVCLPAVVDLNGRYFGGRVVKACFYNLDKFRVLDLAEQV
The following text describes a protein:
Function:
Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.
Sequence:
MKYAGILAGGIGSRMGNVPLPKQFLDLDNKPILIHTLEKFILINDFEKIIIATPQQWMTHTKDTLRKFKISDERIEVIQGGSDRNDTIMNIVKHIESTNGINDDDVIVTHDAVRPFLTHRIIKENIQAALEYGAVDTVIDAIDTIVTSKDNQTIDAIPVRNEMYQGQTPQSFNINLLKESYAQLSDEQKSILSDACKIIVETNKPVRLVKGELYNIKVTTPYDLKVANAIIRGGIADD
The following text describes a protein:
Function:
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.
Subcellular Localization:
Cytoplasm.
Domain:
Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs; The N-terminal zinc finger binds to poly(A) RNA; The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.
Sequence:
MGTRSAAVQIRPPSSTTSATSSPRPVLASISHSAVPASNLQQKVSDADNQSHNESNGSSQFNHQTSPTISTGRKSSPSSPRKFSLPHPARPATATPIASSGASLTTNAPVFVPSGTLNPYHPPSGRTGQQVKLNKSAAEFAPSGLVPTSDSSTLYNHSNTSESAPSYSSSSSTSYPGEPTFHPHNPYAYDAERLLHSQATHHPITEAYMPHDGFMPHNRVSAPSLSNFQRPLNYHLYAPPLPHSSNQHPQQLALNKFFMPASIRETLQKKSAATLQGPTHEVARTPEDLGVYHSLVVLDSPHVTNSSTSSLHPTITGGATNGSSTMNPAANAHRSPYSSRVLKNPCWIYKAFCSLDGKAYCLYRVEGVRLKQGQGEAAIGQVERWRKIRHPAIVNVREAFTTRAFGDHSILFAYDYHPLSQTLYDEHISAKKSSTRTFATDEVEHPSNLSNPTQSGSRYNRHRSANGHPSRIGLSEERIIWSYVIQIANAIKTVHSANLSVRTIDPTKIILTGTNRVRINACGILDVTEYSPNQSPEDLQVEDLRDLGCLICSLASSSICIKTDNNSLTKGVEYVKQFYSAELSEVVAYLLAPALDGHTISIEGLLRMLWSRSLDEMTKVFNHNDLLEESLSRELENGRLVRLMVKLGFINERPEFDHDPNWSETSERYLLKLFRDYVFHQVDSQAKPVTDLSHVLMCLNKLDTSSDEKLTLISRDDQTCAIVTYAEIRRIMDSAFRDLSR
The following text describes a protein:
Function:
Required for normal vision and courtship behavior in Drosophila.
Sequence:
KIEFGKKYFSFAMEGAVKKNSLNSSPLPQRQQRGNSTNKNLGKPTPPKLNAASDGNPAEKKARLGGNTQNGGGVAGGGGTGGGGGGGGATGGVEFSRNRNRGGNQNENRQGFQVANNSHQKQINESPKPAAGNVPAKNNELSAGGGGQNQPNHSNKGQGNQGDQGEQGNQGPNFRGRGGGPNQPNQNANQEQSNGYPGNQGDNKGGQGQRGAGGGKHQRGNRSRRSGGSGIMNSSMGGGGQRGEDFFIAQRLLDISGPTHELPPIELPTDNKFVGRNRLYVGNLTSDTTDDDLREMFKPYGEIGDIFSNPEKNFTFLRLDYYQNAEKAKRALDGSLRKGRVLRVRFAPNAIVRVTNLNQFVSNELLHQSFEIFGPIERAVICVDDRGKHTGEGIVEFAKKSSASACLRLCNEKCFFLTASLRPCLVEPMEVNNDNDGLPDKTLNKKSLEFRHERSVGPRFACLNSFEHEYGSRWKQLHDLFKSKQDSLKRELKMEEDKLEAQMEYARYEQETELLRQELKKRELDNERMKLEWEMREKQAEEIRKREEEYMHRYQNQLLRHEEDMRARQQENDLLMQAKKLNMILDQQEGFGGSNSGFEHFDSPFEVFGNNSNNSTMAGPGGPDNSDGNQHGHIDSWGHRRF
The following text describes a protein:
Function:
Major early eggshell protein secreted by folicle cells into the perivitelline space and incorporated into the vitelline membrane. Localized sulfation by pip may be involved in embryo dorsal-ventral axis determination.
Subcellular Localization:
Secreted. Secreted, extracellular space, extracellular matrix. Note=Secreted into the perivitelline space by follicle cells and becomes incorporated into the vitelline membrane.
Sequence:
MCGRRLLFLAAFGCLLANAFSLPATRNEEFDDGFPESEFDYEERHTREIPAQAYAPPIVYNSQSSYSPAKDQGYSAPAAPVYSPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPASSSYSAPAAPSYSAPAAPSYSAPAAPSYSAPASSSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPSAPSYSAQKTSSYSAPAAPSYHAPAAPASSYSAPAGPSYSAPAAPSYSAPSYSAPASSYSALKAPSYSAPAAPSYSAPAAPSYSSSASPSYSSPASSSYSAPAAPTYSAPKAQSYSAPAAPSYSAPAAPSYSAPASSSYSAPAAPSYSAPAAPSYSAPAAPSYSAPASSSYSAPAAPSYSAPAAPSYSAPASSSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPASSGYSAARAYSAGSAAPASGYSAPKTSSGYSAPASSGSPAASSYSAPASSTASSGYSAPASKSSGYARSEMDHQILGMARTAGGYGSAAPSAAYGAASLPSPPCPKNYVFSCSSVFTPAPCSQGYGY
The following text describes a protein:
Function:
One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix. Note=Found in the non-collagenous matrix of the tectorial membrane.
Domain:
Zona pellucida domain may enable to form filaments.
Sequence:
MVVRAFVLLALFAEASAKSCTPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCYNGVHEGGYYQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDSTVIVKNQPVNYSFSCTYHSTYLVNQAAFDQRVATVHVKNGSMGTFESQLSLNFYTNAKFSTKKEAPFVLETSEIGSDLFAGVEAKGLSVRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDETVLVHENGKDHRATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVNCDKRKRMLRDQTGGVLVVELSLRSRAFSGLCDFSDVLLHLILMLGTWAVL
The following text describes a protein:
Function:
Major myo-inositol uptake transporter.
Miscellaneous:
MISCELLANEOUS: When iolT is inactivated, inositol uptake is almost abolished even though iolF is active.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQLNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPNVTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNAILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIRDEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIMYYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTALLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMGVTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQLEENFRAYDHSGAKKDSGAEVIG
The following text describes a protein:
Function:
Required for cell fusion. Negatively regulates Sho1p signaling to ensure efficient cell fusion; Interacts with SHO1.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MVATIMQTTTTVLTTVAAMSTTLASNYISSQASSSTSVTTVTTIATSIRSTPSNLLFSNVAAQPKSSSASTIGLSIGLPIGIFCFGLLILLCYFYLKRNSVSISNPPMSATIPREEEYCRRTNWFSRLFWQSKCEDQNSYSNRDIEKYNDTQWTSGDNMSSKIQYKISKPIIPQHILTPKKTVKNPYAWSGKNISLDPKVNEMEEEKVVDAFLYTKPPNIVHIESSMPSYNDLPSQKTVSSKKTALKTSEKWSYESPLSRWFLRGSTYFKDYGLSKTSLKTPTGAPQLKQMKMLSRISKGYFNESDIMPDERSPILEYNNTPLDANDSVNNLGNTTPDSQITSYRNNNIDLITARPHSVIYGTTAQQTLETNFNDHHDCNKSTEKHELIIPTPSKPLKKRKKRRQSKMYQHLQHLSRSKPLPLTPNSKYNGEASVQLGKTYTVIQDYEPRLTDEIRISLGEKVKILATHTDGWCLVEKCNTQKGSIHVSVDDKRYLNEDRGIVPGDCLQEYD
The following text describes a protein:
Function:
Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
Sequence:
MLSAHLIRNLRNASKLASVAGPNADRIVNVKWSDGKTGEFPLIWLRDTSPDAATYTISPAMTARNLTMLEFDVEQKARKLWIDGDGDSLKIEWDSGVLSTFPSEWLQMRNPSDQEARKRRRKVYLFPEETWGKEEIEKKLKRFSHEEFMKNDRVVHDFLEAVCIDGIAVLKGAPQGARGAIEAIGDRIGMIKRTHFGIVFEVSTKADASNMAYASNGGLPFHTDFPSLSHPPQLQMLHMLQSAEEGGNSLFVDGFHVAEQLRVENPEVFRILTTHSMEYIEEGYDIHEINGKEFRFDYDMCARHKVIRLNDEGKVNKIQFGNAMRSWFYDCEPNQVQNVYRAMKTFTDHCYQPRNVLKFRLEDGDTVLWANQRLLHTRDGFKNAPGKSRTLTGCYFDWDIVKSRVRHLRDKLELEQNQPSA
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MRTIKLILEYDGTNYAGWQLQPNGLSIQEVVEGALARLLKEPVRLRASGRTDAGVHARGMVAAFDTDRSIPLRAFSDGLNALLPPDIAVRSADEALPGFNPRFAATGKHYRYTIHRGERRSPLVRLQSWHVRGALNLAAMREAARHLTGERDFASFRTAGCAARTTIRRVDAVEISDDGEMLTVDVHGSGFLRNMVRIMVGTLVEVGRGKLTPEHVAQMVVCPGVVPAGPTAPPQGLCLQKVRF
The following text describes a protein:
Function:
Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
Sequence:
MSPPQTHVYKVAMTCEGCSGAVERVLNKLKDKGVVDVNIDLPGQTVKVKTTLSSQEILDVIKKTGKETEFIQTV
The following text describes a protein:
Function:
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform 7]: Dominant negative isoform, resistant to Fas-mediated apoptosis.
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Membrane raft; [Isoform 2]: Secreted; [Isoform 3]: Secreted; [Isoform 4]: Secreted; [Isoform 5]: Secreted; [Isoform 6]: Secreted.
Domain:
Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.
Sequence:
MLGIWTLLPLVLTSVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRSNLGWLCLLLLPIPLIVWVKRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVMTLSQVKGFVRKNGVNEAKIDEIKNDNVQDTAEQKVQLLRNWHQLHGKKEAYDTLIKDLKKANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSSEAASGLWRSEDMTLLRLTMQRETAHDSVLKLGQLAAFQFIDLNSDVSAFQRDFVQEVRRCDGMERKLRYLHDEIEKAGLTCVSTEAIGRESLFALEHKIDEYEGELRELNGQYQSLLEESNRTQEHLEVLSREFGSGIRQSPGLNLLTGVIPKDRIATLERLVYRITRGNSVLHTDEITTPFSEGEKERMVQKCVFGVYFATPRLWESLKRISEVNGASLYPYAESTERLQYMRDTLNSQLETMKHTLQQSLLRQRHLLTSISHNVCQWRQTVAVEKSVFSTMNMLKFSGSTAVAKGWAPVRSLDRIRASLQEAEYLSGAQVLTIVEEISTKEKRPTCFFTNKFTVCFQSIVDSYGMARYKEVNPGVLTIVTFPYLFGIMYGDIGHGVMLTLFAAFLLIKEKDWEGRKLNEIFAMIFDGRYLLLLMGLFAIYVGFLYNDFFGFSVDTFRSGYQWPPLNGNTQEGDMQPSSPSGVTPARSVIFGIDSAWAETENKLEFYNSVKMKCSVIIGVVQMVAGVILSLMNHIYFGDRIQIWFRFVPEIVFLLCTFGYMCVLIIIKWCTNWDQRTSEAPSLLETMTNFFLQPGTVNVPLYKGQEFVQVLLLLIAFAMVPILLCAIPMHEKKEHERKMRLQALARRNEDERHEGSEDDYDEDEKFDFSEVVIHQVIHTIEYVLGCVSNTASYLRLWALSLAHSQLSEVFWSFTFLMALDMDKGSGVFVFFGLCVWMCATVAVLLGMESLSAFLHALRLHWVEFNNKFYAADGYPFTPFNIAEVLKELD
The following text describes a protein:
Function:
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Miscellaneous:
MISCELLANEOUS: Present with 1630 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTIRSSMKNNAELESKSVLANESNIISTFTRRIIKEKSGNYQVLKRSLDGKLIYPEATGISSNRGNKLLQRSEVVTRRDLNNSKPMIEQTVFYNGSEHRLLQTNIVTDSRRKRIKFTPDINVEPVLVGDENDIDGSEKEDENITDEYYGEEDDDDLSKLVNVKEILTPILSLGDIINHKTISRTFSSPILKNLALQIILMIEKEQMSVVRYSQFLEVFLGDHPEPIYESNLNLPSYNHNLTLPEDRGASDEDDINNKNNINEVNSNSLSTEAGHINNGMEEFGEEDPFFALPRLEQSNALLSLLPSSSGSASISTLTAAEQQQLNEEIESARQLSQIALQRNKEFIRNLQKIRKSVIKANRIRGRILNWSREYLGISDDDITIPVALRVVKRGLISATTNKTTNFEEEIENTMEDGVVDDNEPDEEANRA
The following text describes a protein:
Function:
Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
MNSDSGCSPDNEPLELGATFAVRSFSEPIPGSSDWIKPNEFVENNHKINHVGPQSLLGDNLELHEYKAWLSGHNSMFIPEDTNALSGTVFNQPKLSHEWSSNFEPQAHQSNPCHLQSCPPPAHFDGSLERQMYGCSVVNQKFQNEVSGESSLVLSRPPLAPNHRSQQHGFSNVQASKTTSSRGSVHRLLVLYLIFRSKQLDVIRSQQEYVDYLHLVVCRGLDCKCNKYRALVSHFDNCQTTDCKICGPVHQIFHNKKIKSVPASSPYSTDKMTTVSENPRGCVIGNPHPRDFTFQETQPDPKRLKIEAVPRDDWSLSSVVLSCSELQAGCLLDDEENTAKMNKELLSSNEGSPGVIWNGDADNGGPETETICFSMTDGLLGLGQSSEDPRNSAALNNVALSHSEEFNFVDKHQELDCDNTGNIKCDVTSSCQSLNSDGISILPEEPAIDPGEETTLMSVTENVCFSKTDGLLGLGQSSEDPRNSAALKNVTLSHSEGFNLVDKHQEMDCDNTSNIKCDVTFSCQSLDPDGVSILPEEPATDPGEKTKIISVAEHDRIDTNCDSSNSDYQYGTKLEELKGSGVSLTDAFTAEQIKMHLDSLRQCTIPNAEKELSGDKTAQTAGANSCQLCLVDVLAFAGPPMYCSWCQLLIKHKLNYYWATDESGTQYCFCNSCFSHSRGGRISSTGGLTFSKAKLQKAKNTTELDEPWVQCDKCERWQHQVCALYNSKRDLEGKVDYICPKCRLAEIEAKKHVPIPPATGARDLPRTKLSDHIEQRLLRSLEHERKQRAELIGKSPEEVPGAADLVVRVVLAVNKQLEVKQEFLDIIPGESYPTKFSYKSKVILLFQKVECVDVCLFSMYVQEYGSDCGNPNKRSIYISYLDSVKYFTPEIKTVAGVALRTIVYHEILIGYLDYCKQYGFKTCYIWACPPRKGEDYILYCHPETQKRPDDNRLSQWYKKMLKKAKQDNVVVEYTNFYEHFFIPSGECNSKITAARLPYFDGDYWSGEIEHHVRNSEKNEGGDSERKLKTQMTRRTLKAMGHTDTTEDVRAMQELGAKIHHKKDDFFVVHLQFICTNCNEAILSGSRWSCNQCSKFHLCSRCFELKKTPDGLETLKTCRGKKHQLWQIAVSGVAADTEDNDVILHNEFLDNRHSFLDFCQKNNYQFDSLRRAKYSSMMILHHLHKMSTFTTQTICSICHHEPVVRWHCEICSEFHACNACYQKEGDRCHIHKLVQQSRKADCRTNTEHIQQQGQLKIRWLLNVLEHANQCGATKDNPCTYPNCHDMKILFLHGAKCQLRLPGGCRHCRRIWFLLDLHSKICRISNCGIPRCMDIKRHKQMIATQSDLQRRALLHSQ
The following text describes a protein:
Function:
May negatively regulate Notch-induced cell proliferation in the eye-head primordium. Required for development of the supraesophageal ganglion and ocelli. May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation. Plays a role in tracheal development.
Sequence:
MVVLEGGGGVVTIGNNQYLQPDYLAPLPTTMDAKKSPLALLAQTCSQIGADSSAVKPLLAMDKNKTKPGACSSSSNSSSSSGSAEISAAKSPSGQAKSPKSSTPISSTATSASLSNTSTGEIKLAFKPYETNVLSHQNQNSFKSSSSLDAEPTRPSSKNSSSAQERVPSRSKSNATPTDGGKAEISAHDSSSSRKTVSPSGSSQRGASPIVRSGMEVLNNANGTAQHPKEMSSMAAAAAAAAAAYKAAGPYGLNPLSALCCPPGMEQHANPAFRPPFAGGFSHHHAAMLAVAANGGYPGGAPGGGPAGQPNPYISYQRIKTPAGGEAIVPVCKDPYCQGCPYSAHTQQMLMGAPCPAGCTQCEHQKYGLAMASAAGLPPAHPYSQAAAAAAANAAAARSAPYVCSWVVGDAYCGKRFQTSDELFSHLRTHTGNLSDPAAAAAALAQSQAQSLLGTLFPPSALRAGYPTPPLSPMSAAAAAARYHPYAKPPPGALAGGPSPFGAAGAFNPAAAAAAAALGPYYSPYAMYGQRMGAAHQ
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Subcellular Localization:
Mitochondrion.
Sequence:
MNHLHRLFRITQVDRPVLLAITRRLSSKVPTEPTWKEVDESKLPNPTKIDQDTIAHLERLALVDFANKEGIRRLEAAIRFADQMFLVDTTGVEPMDSVLEDRELYLRDDVVTEGNCKDDILRNAGKVVEDYFVAPPGNIPLPKKEEYDS
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MERTQSSLHSPTNGSLITILSIDGGGIRGIIAGVILKFLEFELQKLDGNHVRLADNFHMVAGTSTGGLVAAMHTTPNKNNHLLYAAKDIVPFYLEHCPKVFSESFASCGINLELWALNRDLSLLQTGNFSFLFYSRFTSTLTSPVSSISGFAASYNQSSIDSIKIQERICKRKISGINRVKCVLQILGSLKLDGGLVQG
The following text describes a protein:
Function:
Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.
Sequence:
MDLHRRVQSQTSSTSTATPSKHAFETRVADVKSPKSDINALILDYLMMEGYPKAAEKFQKEANLKPRQEDPTINARQQIQHAIHVGDIQKAISDLNELDPGILDSDPHLHFSLLRLQLIELIRNARGYDPSAAINFAQEKLAPRAASNEQFLKELEKTMALLIFPADKLQPDLAALLHSDLRRNTAAQVNEVVLQRHTERREAAIRQLVRMRAWAEASCRSKKRNLPDRIELGLNGDDNGHDPMVTT
The following text describes a protein:
Function:
Involved in plant defense. Confers resistance to the fungal pathogen C.fulvum through recognition of the AVR9 elicitor protein.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The extracellular leucine-rich repeats are required for the specificity of the elicitor protein recognition.
Sequence:
MGCVKLVFFMLYVFLFQLVSSSSLPHLCPEDQALALLQFKNMFTVNPNAFHYCPDITGREIQSYPRTLSWNKSTSCCSWDGVHCDETTGQVIALDLRCSQLQGKFHSNSSLFQLSNLKRLDLSNNNFIGSLISPKFGEFSDLTHLDLSDSSFTGVIPSEISHLSKLHVLLIGDQYGLSIVPHNFEPLLKNLTQLRELNLYEVNLSSTVPSNFSSHLTTLQLSGTGLRGLLPERVFHLSDLEFLDLSYNSQLMVRFPTTKWNSSASLMKLYVHSVNIADRIPESFSHLTSLHELDMGYTNLSGPIPKPLWNLTNIESLDLRYNHLEGPIPQLPIFEKLKKLSLFRNDNLDGGLEFLSFNTQLERLDLSSNSLTGPIPSNISGLQNLECLYLSSNHLNGSIPSWIFSLPSLVELDLSNNTFSGKIQEFKSKTLSAVTLKQNKLKGRIPNSLLNQKNLQLLLLSHNNISGHISSAICNLKTLILLDLGSNNLEGTIPQCVVERNEYLSHLDLSKNRLSGTINTTFSVGNILRVISLHGNKLTGKVPRSMINCKYLTLLDLGNNMLNDTFPNWLGYLFQLKILSLRSNKLHGPIKSSGNTNLFMGLQILDLSSNGFSGNLPERILGNLQTMKEIDESTGFPEYISDPYDIYYNYLTTISTKGQDYDSVRILDSNMIINLSKNRFEGHIPSIIGDLVGLRTLNLSHNVLEGHIPASFQNLSVLESLDLSSNKISGEIPQQLASLTFLEVLNLSHNHLVGCIPKGKQFDSFGNTSYQGNDGLRGFPLSKLCGGEDQVTTPAELDQEEEEEDSPMISWQGVLVGYGCGLVIGLSVIYIMWSTQYPAWFSRMDLKLEHIITTKMKKHKKRY