lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.
Subcellular Localization:
Secreted.
Sequence:
MISHFMTPLNILLCAICCFSTAQTIEDIIHVKLNNDFENGILENEEVISDCQVKDLTKWDKLFTMLENSQMRENILLETVNEVVSVELQSLRAEMLQFVSSFAGACASHIESATTKITTEVNSIQALASKCEQAQRRENSLDTKKESDLEKAILLNFNISDRISRIEEDLKQEALRTKEDSYNCAEASFTLAAVLRTLDETTAKLQTAQSWISQRYLPGGCEIAILFPMRSPKIYASVHPADMTLQAFSFCVWVKVTEALDRTIIFSYGTKRNPYEIQLYLNHQSLVLVIGDGQNKVIADNVVEPSNWTNVCGTWSSENGKATLWVNRENRATSYDIAKGYEIPNRGIFQLGQEKNGCCVGGGFDESLSFSGKITGFNFWNKVLSDGVITWTGTEESCSFRGNIVGWGTTEILLHGGAQYIH
The following text describes a protein:
Function:
Involved in the biosynthesis of validamycin B, a component of the antifungal and antibiotic validamycin complex used as a crop protectant. Catalyzes the regioselective hydroxylation of validamycin A (4-O-beta-D-glucopyranosyl-validoxylamine A) at the C-6 position to yield validamycin B. To a lesser extent, also able to convert validoxylamine A to its hydroxylated derivative.
Sequence:
MTGSVPIVDLEAWRAADEENRASLAEIIDGALHTVGTFLLAGHGVPAELTARMRTAGRSFFDLPWEKKEPHAVQRPHDNGWRGLVKHRTDTIEGTGGAPDLHEAFHMGPTHRTGDDAFDALYYPANKWPAELPELRETALAYTAHMTRVAGAVMEMLAGVLGLEPAFFTSRCEHATWTQSVNWYPSLDTVGQTAEGQMRVGPHTDFGTITLLDRQQGVSGLEVWSEEDGWFAPPFVEGTLLVNLGDLMHQWTDGRWRSLRHRVLAPSASAPQEELVSLVYFFDADPEAELVPLAAPVGGGAGMPTVNVGETILKKNIQMLTDLKGHGLFQGELSLSRPGSADSPGSSPADDHPSRPGRHPAQGPQ
The following text describes a protein:
Function:
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Domain:
The CRIB domain mediates interaction with CDC42.
Sequence:
MSTKVPIYLKRGSRKGKKEKLRDLLSSDMISPPLGDFRHTIHIGSGGGSDMFGDISFLQGKFHLLPGTMVEGPEEDGTFDLPFQFTRTATVCGRELPDGPSPLLKNAISLPVIGGPQALTLPTAQAPPKPPRLHLETPQPSPQEGGSVDIWRIPETGSPNSGLTPESGAEEPFLSNASSLLSLHVDLGPSILDDVLQIMDQDLDSMQIPT
The following text describes a protein:
Function:
Required for the establishment of head structures. Required to function as an early patterning gene in the anterior-most blastoderm head segment anlage and for the establishment of a specific head skeletal structure that derives from the non-adjacent intercalary segment at a later stage of embryogenesis. Binds the consensus DNA sequence 5'-[AG]TAAA[TC]A-3'.
Subcellular Localization:
Nucleus.
Sequence:
MHTLFSDQNSFTRHYAQTAAGYGSASAVAAASSASAAAAAHYAYDQYSRYPYSASAYGLGAPHQNKEIVKPPYSYIALIAMAIQNAADKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECFVKVARDDKKPGKGSYWTLDPDSYNMFDNGSFLRRRRRFKKKDVMREKEEAIKRQAMMNEKLAEMKPLKLMTNGILEAKHMAAHAAHFKKEPLMDLGCLSGKEVSHAAMLNSCHDSLAQMNHLAGGGVEHPGFTVDSLMNVYNPRIHHSAYPYHLNEDNLATVASSQMHHVHHAAAAHHAQQLQRHVAHVAHPLTPGGQGAGGQSSGHSPTTISTPHGPAHGGWYTPETPPSEPVPHNGQQGTPTHPGHNNNNSSSVLNHNGVGNGGGGGGGGGGGSSSVLTSSPTSALGFRDMIFEQNQSCQLDTGSPTGSLQSASPPASASVAAASAAAAAAVISSHHHHHHHHAALSGNLGQLGQLSNLSHYRPHVGHYQEYGIKYGV
The following text describes a protein:
Function:
Olfactory receptor specific for trace amines, such as cadaverine, putrescine and spermine, but not by spermidine or triethylamine. Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (By similarity). Trace amine-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
In addition to the well known disulfide bond common to G-protein coupled receptor 1 family, trace amine-associated receptors (TAARs) contain an unique disulfide bond (Cys-24-Cys-186) connecting the N-terminus to the extracellular Loop 2 (ECL2), which is required for agonist-induced receptor activation.
Sequence:
METLNESIRNSSLLCVEAFHNFHCTYNDVSEAERAILIAIIIPAIAITIFGNLLTVVSILYFRQLQTRTNVLTLFLAVADLLVGLLIMPFSAMRSVYNCWFYGWTFCKIHSWFDYTLCTLSVLLLSCISFDRYVAISDPLRYHQRITNRTCALMLLFCWLCLPFYGLVFMLEWNLVGLEEELAQICPDDCPVLLNLPFAMANTIFGCVVPMILMTLAYGRIYQLARQQARKITSTAMGSNVDSARSSLRREHSATITMGIIVGVFISLWMPYFVVSTTESIFGYQASSLAWEFINWFTYINSTVNPILFAAFNRPFRNAFYLILSGRIFSSSYRGVDLFNVQHGSKVNQGAKRCVSTLIGKESDR
The following text describes a protein:
Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Sequence:
MDSSRQRESQLGPENGTIWTFSPSGLSPVSELSAGLGDLDCQDSTTPRRRLWQSPEQLGCSPAPQSEVSAETQTPTVLRDFASCASCAWQLNVLFCPSAEEELRKKQSQEARKRLRVKLSSLFASPAEAGGRRDPSSQAEESSGQGDQQPPAHRVRHRALLKTLRSRCWAPALDIPHSAIQDRNLIGDFSKPHLFAREKGEHQDLQYVSGQTVASLLLGEYSTAVRSFLIVDCRYPYEYQGGHIKGAVNLHSEAQVEAALLHEEVLSRLSPTVPSPSSCVGTWAPTGSSPRRLLIFHCEFSSERGPWLCRYLRKMDRRLNAYPRLFYPELYVLAGGYKEFYSHFESLCEPCSYVPMLQEEFSDQMHRYRRKRRTRPTQFGTKQLLQ
The following text describes a protein:
Function:
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization; Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
Subcellular Localization:
Cell membrane, sarcolemma. Nucleus, nucleoplasm. Postsynaptic cell membrane. Secreted, extracellular space.
Sequence:
MRIPFIVLGLLLVTTVFANDSTRVFIGELFEHNLGDNFTVASGKNNRPLPSWLMIRDQILTGIPTENDVGKHTVMVSQKITSRRRKPTYLYLNVEEEVISPCGTINNTFWMETYHEQEATLANRIETALAMNELELDPNVKTVRVYSYNFSLINRNLEEIGQEAVNGNYMAIWRVACEDFDEAVNYMDEFVDREDVDYDSLKLAKGFFKKGVAPTPTPEPVEEDETTTEYLRTTTELIRTTRRVFNDNKPILLNRLPSFVCTRGEICELRVPAETFKDAEDGDTFKMKLTVLALDNAEVWMINEANKGLIGIPMRTGEFNYRLEARDKAGQLASAPFQINVKPALPTNHRVELEMDMPTPQQMATNPAKRNLLMRALARSLKAPINTFTIQEIGSKNNKTMVAFSNNSIPYKVCDKVALDAMASKMIMKQKMRTKTEFVKTMGNQFYVRRATMIRHGNCDETVEISTTAPTIQSMQEADSQLLLICILLFLLLAIAVAIIIYCACIKKSGKKKSPSTEYVSKGLPVVFPDEVEENDPTNAGTPMLAREERPPLKVSQHENPLYKPPPPIASNSPRLGHASSSSNQRLQSPFIPP
The following text describes a protein:
Function:
Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.
Subcellular Localization:
Cytoplasm.
Sequence:
MLTIKRIATVVSNYQEERGEKDNAAVAVEGEAKGCGRNCLGKCCLPASDLPLYTFKVAGEDCTEESIFYQEPPETSFLLNLLLGQWENRMNRGLFRYDVTTCKTKVIPSDYGFIVQLNEGRHLKKRPTEFRVDQVLQDFDEKKFNFTKVGHEEVLFMFEQSDDCYSHFFPSAPAIFKPTSPNVVAINLLMNKVVKFLLVSPIEYGHILLIPRVLDCLPQRIDHMSFFLALSLAKEAADPFFRNKVVYLHHKFLVIVHLIVLSVNGQCYAEKQARGEVSQELLETQVNPVVWEIGGHVVLKRREDFENVSEDYAWRLLAEVSLSEESFREVKA
The following text describes a protein:
Function:
Binds together with bS18 to 16S ribosomal RNA.
Sequence:
MVRMYETIVIVQPELGDDELKGLTAKVTDIIGSFKGVLHRLEDWGVRKLAYPVKKSVRGRYYYVRFDGDAPLIAELERRLRLDDKVLRYQSVKLEKEAAAPAPKAAPVESAPAVEAE
The following text describes a protein:
Function:
Inhibitor of plasmin and trypsin. Also has a weak affinity for chymotrypsin. Could serve to neutralize the activities of one or more serine proteinases generated by the proliferating trophoblast during the formation of the noninvasive placenta.
Sequence:
MSRLCLSAALLLLLGALVASTPGDEESSLVRAGPPGFCREPPYTGPCSAHFVRYFYNATTGLCQSFVYGGCRGKQNNFMDEKECLHTCDTCAKAQGKRGNCASEMLKSTRPQGWAVAAFQMG
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAPPQGKPENVLRLADELIALDQHSSALQSLHETIVLKRSRNAQGFSLEPIMMRFIELCVHLRKGKIAKEGLYTYKNAVQNTSVTAIENVVKHFIELANKRVQEAQEKADKISVEYVDDLEATETPESIMMSLVSGDLSKSRTDRALVTPWLKFLWDAYRTVLDILRNNARLEVMYQLIANSAFQFCLKYQRKTEFRRLCELLRSHLGNASKFSNAPHSINLNDAETMQRHLDMRFSQLNVAVELELWQEAFRSIEDIHSLLTFSKRAPAAVMLGNYYRKLIKIFLVCDNYLLHAAAWNRYFTFTNVQKPATANFVILSALSIPIIDANKLSGPSIEAEDAKSKNARLALLLNLSKTPTRETLIKDAISRGVLSFCDQAIRDLYQILEVEFHPLSICKKLQPIIKRLAESNDTAQYIRPLQQVILTRLFQQLSQVYDSISLKYVMDLATFEEPYDFNPGQIEKFIMNGNKKGAFSIRLNHIENSISFSSDLFSNPIKSSDSVSLQSTPSELITSQLTRIAKSLSSVLMRFDTDFCLLRKQQAEAAYERAQAGVEQERKAVIAQRSLLELRRGQADTLATQREAELAAQRALKQKQESEAESLRVQEEINKRNAERIRREKEAIRINEAKKLAEELKAKGGLEVNAEDLEHLDADKLRAMQIEQVEKQNKSMNERLRVIGKRIDHLERAYRREAIPLWEEDAKQQAEHDREIFYEREKQRKEVQERKHEQAIKDKKAFAQFASYIHAYKQNIDDERDKAYQEAYAKAKNVIDAERERQRKEIFEQKLAEAIREAEEEAARAAEEEANRELHEQEEAQKRAIEERTRAAREAKEREQREMAEKLERQRRIQQERDEEISRKLAEKAAARRANIGASSPSPGAWRRGGASAGGVSRDSPRYSRGGYSRGSVPPRETLAPSKGAYVPPSRRNQQQQ
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEHPVQEWQDQVHIIWAHLTSSEKKKFSSTANLDEIFQACLSHFRQDEEQLIERLCCNLTVAKDPNAVQFFKEEGNKRFAEKQFATAAGLYSKAITHAKSGSEAMAICFANRSAALFHLGQYSVCLEDIKRAQDQGYPERLRNKILQRKTECFQKLRKPSSSTSHTPKLECVEIVKPETGPQQTMSTERLKEMGLDGNPQITNASCALHLNFDTCKGRHLLASRNIEQGEILIWEEAFASVIIPERNQWRKGEKWDAKITVCDLYCHHCLNKVIASLPCQHCSFASYCSQECMDKAWRSYHYIECSLGCLLLALGVFCHTALRAVLVAGCRLVSQLLEGTGSADAGDDMKDCHSKSSYHEKYCSSYQAVVNLLPHTENHQAERKFLCALTAAALYKKLCLVMAKNALSSPSSQTEEPMTKESSRTEDWSSGRQFLGPTILRHMLQLYCNAQAVTVLQEEHDESNLSIVKSSKSVRLATAVFPVLSLLNHSCDPNTTVSFKGRFVTIRANRPIRRDEEVTHCYGPHKLRIGVAERQQSLKDQYFFTCRCKACTEELKGKKTHGFCCPMCRTQLEGEEELYCTGASCAFTAARVQFTSRLKLLENRIQIAKGQLQDNKTDDAKIMLMSCLSEAERFLSQNHLLVGEIMDHLAQAEASDGNWRAAAGHLRKSISIVEVHYGSSSMELGHELFKLAQILFNGFEVLDAMKTIMEAQKVLSMHYGSDHNLVQELKTMETCLIQFHGYPRK
The following text describes a protein:
Function:
Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MEHPSKRRRLTPSPPPISSPIETSSDELAAGSDHDQERRRVSLNAYPPKRPYPRSRSFSSSESPDELAMDADVYWRSRNRGRDDSPWARSDEENDENEADEEENENEDDEHDNMNGDDNGREANGSRERDLDEMDTVGENEPETDPDRSPTPVPPPPPPKPESVNYRQKFLLRGHLRGVSAVRFSPDASMIASGGADGAVKVWAASTGKLIYTFEGHLAGISTISWSPDGATIASGSDDKTIRLWNVLTGKAHPTPFIGHHNYVYAIAFSPKGNMLVSGSYDEAVFLWDVRSARVMKSLPAHSDPVSGIDVVWDGTLIASCATDGLVRIWDTSTGQCLRTLVHEDNPPVSSVKFSPNGKYVLAWTLDDCVRLWDYVEGRCLKTYQGHSNKKYSLSGAFGVYGQSIPGRTPGYAFAVSGSEDGAILCWDVVTKKVLQRIEAHDGVVLGVDTCSTGEGRFMVSCGLDGTVRVWEEVGPEREPEPEPEPEPGQCPDQDQDQGRDWDMDSEMREAGELAVETRDPT
The following text describes a protein:
Function:
Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate-producing form. Inactivation of mucB causes conversion to mucoidy.
Subcellular Localization:
Periplasm.
Sequence:
MRTTSLLLLLGSLMAVPATQAADASDWLNRLAEADRQNSFQGTFVYERNGSFSTHEIWHRVESDGAVRERLLQLDGARQEVVRVDGRTQCISGGLADQLADAQLWPVRKFDPSQLASWYDLRLVGESRVAGRPAVVLAVTPRDQHRYGFELHLDRDTGLPLKSLLLNEKGQLLERFQFTQLNTGAAPAEDQLQAGAECQVVGPAKADGEKTVAWRSEWLPPGFTLTRSFMRRSPVTPDPVACLTYGDGLARFSVFIEPLHGAMVGDARSQLGPTVVVSKRLQTDDGGQMVTVVGEVPLGTAERVALSIRPEAAAQK
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTTILTQVFKELGYTQDHSLLDVRLAAGYASVILAAASFYLDYTFGFDFARPYLVYTVPLFFVLEFFVSGWLYFKERNVAYVGKKGDTKVTVSTTAANPGVDYKIVVDVDGGKKTVDAKFNDWFDFNGFIVYSKFAGVFEALLEKKDQ
The following text describes a protein:
Function:
Inhibits protein synthesis in animal cells.
Sequence:
PRGSPRTEYEACRVRCQVAEHGVERQRRCQQVCEKRLREREGRREVD
The following text describes a protein:
Function:
Catalyzes a trans-dehydration via an enolate intermediate.
Sequence:
MATLLVLHGPNLNLLGTREPGTYGSTTLGQINQDLERRAREAGHHLLHLQSNAEYELIDRIHAARDEGVDFIIINPAAFTHTSVALRDALLAVSIPFIEVHLSNVHKREPFRHHSYFSDVAVGVICGLGATGYRLALESALEQLQRP
The following text describes a protein:
Function:
Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
Subcellular Localization:
Bacterial flagellum. Periplasm. Periplasmic flagellum.
Sequence:
MPAFTIPGLSSGQDTNLIVKKLVELEAKPIRRLEQQNSFNKAQSKAWNDLKTVTTDLQEKTRALISFTAPFAMKSIVSEPEGIISGDASRSASSGKRRIEIKELATSHQISGEKTDVNKQIPAGKFKIFSGDSEKEIEFSGGTIRDLASSIKVSAAGLVNTGLVKVDGDNYVLTLTATFSGKDRKLKFEDSNGVLQAANLVGATEPADPPKELNFLPEKDQIQIFQPEKYGISSDSKPVFKEESGKKWMEIASVASFQFGIPTTEFKKNTKIELATSTEFAPEEKIELGILYKESDKEKMIFETASKENGKVVLNLKNFPSGQKVHKILLANSSGKTIILDFFHIIIPGEFKGAKPSKEIAEAKDAVFLVDGIEVNRPKNEGLTDVLDGVSLNLHKKTEGPVNIDIKTDSDKGIEMIKEFVAAYNTVLKFSKESTAVDKNSTVRDGKEEGGEIGQSFWEGKTKTGLLSGEHTVIRLIAGMKTVASSSYPVSGENSVRMLSDIGINTGKVGSKWADIQDGFLILDEDKLRSKLAENPDSVRNLFAIDTNSDARMDTGVGVDLLEHIKPYTQYAGGLVSGKVKMLEEQVADNNKKIKEFENHLVSYEKKLKSKFLYMEQGVGKNKAVGAYLNNNLKGARNE
The following text describes a protein:
Function:
Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments.
Subcellular Localization:
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MGDDSEWLKLPVDQKCEHKLWKARLSGYEEALKIFQKIKDEKSPEWSKYLGLIKKFVTDSNAVVQLKGLEAALVYVENAHVAGKTTGEVVSGVVSKVFNQPKAKAKELGIEICLMYVEIEKGESVQEELLKGLDNKNPKIIVACIETLRKALSEFGSKIILLKPIIKVLPKLFESRDKAVRDEAKLFAIEIYRWNRDAVKHTLQNINSVQLKELEEEWVKLPTGAPKPSRFLRSQQELEAKLEQQQSAGGDAEGGGDDGDEVPQIDAYELLEAVEILSKLPKDFYDKIEAKKWQERKEALEAVEGLVRSPRLEAGDYAELVKALKKVVGKDTNVMLVALAAKCLTGLAVGLRKKFGQYAGHVVPTILEKFKEKKPQVVQALQEAIDAIFLTTTLQNISEDVLAVMDNKNPTIKQQTSLFIARSFRHCTSSTLPKSLLKPFCAALLKHINDSAPEVRDAAFEALGTALKVVGEKTVNPFLADVDKLKLDKIKECSEKVELVHGKKSGLAAEKKESKPLPGRAAASGAAGDKDTKDVSGPKPGPLKKAPATKAGGPPKKGKTTAPGGSASSGTKNKKGLETKEIAEPELSIEVCEEKASAVLPPTCIQLLDSSNWKERLACMEEFQKAVELMERSEMPCQALVKMLAKKPGWKETNFQVMQMKLHIVALIAQKGNFSKTSAQIVLDGLVDKIGDVKCGNNAKEALTAIAEACMLPWTAEQVMSMAFSQKNPKNQSETLNWLSNAIKEFGFSELNVKAFISNVKTALAATNPAVRTSAITLLGVMYLYVGPSLRMIFEDEKPALLSQIDAEFQKMQGQSPPAPTRGISKHSTSGTDEGDDGDEPGDGSNDVVDLLPRVEISDKITSELVSKIGDKNWKIRKEGLDEVAGIINEAKFIQPNIGELPTALKGRLNDSNKILVQQTLNILQQLAVAMGPNVKQHVKNLGIPILTVLGDSKNNVRAAALATVNAWAEQTGMKEWLEGEDLSEELKKENPFLRQELLGWLAEKLPMLRSTPTDLILCVPHLYSCLEDRNGDVRKKAQDALPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKANMPSKPAAPSKAVSKPMGGSAPAKTQPIPAPVEDSVSNTMEAKPDPKKAKAPGVSSKAKSAQGKKVPSKTTLKEDDDKSGPIFIVVPNGKEQRMRDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHADFQHHNKALAVMVDHLESEKDGVISCLDLILKWLTLRFFDTNTSVLMKALEYLKLLFTLLSDEEYHLTENEASSFIPYLILKVGEPKDVIRKDVRAILNRMCLVYPASKMFPFIMEGTKSKNSKQRAECLEELGCLIESYGMNVCQPTPGKALKEIAIHIGDRDNAVRNAALNTIVTVYNVHGDQVFKLIGNLSEKDMSMLEERIKRSAKRPSAVPVKQAEEKPQRTQNINSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQLDLDEIENDNGTVRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDISTSIQALTQIDEVLRQEDKAEAMSGHIDQFLIATFMQLRLIYSTHMADEKLDKDEIIKLYSCIIGNMISLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVIRSVNLLVVKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFMKVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKYSDTDIEPFLKNSSQFFQSYVERGLRVIEMERESKGRIPTSAGISPQMEVTCVPTPTSTVSSLGNTNGEEVGPSVYLERLKILRQRCGLDNTKQDDRPPLTSLLSKPAIPPVASSTDMLHSKLSQLRESREQHQHSDLDSNQTHSAGTMTSSSSTANIDDLKKRLERIKSSRK
The following text describes a protein:
Function:
Autophagy-specific protein that functions with ATG13, ATG29, and CIS1/ATG31 in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles, through interacting with and regulating ATG1 kinase activity. Plays particularly a role in pexophagy and nucleophagy. With ATG13, is required for ATG1 activation by autophosphorylation of 'Thr-226'. Recruits ATG9 to the pre-autophagosomal structure. Also plays a role in regulation of filamentous growth.
Miscellaneous:
MISCELLANEOUS: Present with 358 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MNEADVTKFVNNARKTLTDAQLLCSSANLRIVDIKKKLSSWQLSISKLNFLIVGLRQQGKFLYTILKEGIGTKLIQKQWNQAVLVVLVDEMKYWQYEITSKVQRLDGIVNELSISEKDDTDPSKLGDYISRDNVNLLNDKLKEVPVIERQIENIKLQYENMVRKVNKELIDTKLTDVTQKFQSKFGIDNLMETNVAEQFSRELTDLEKDLAEIMNSLTQHFDKTLLLQDKKIDNDEREELFKVVQGDDKELYNIFKTLHEVIDDVDKTILNLGQFLQAKIKEKTELHSEVSEIINDFNRNLEYLLIFKDISNLIDSFKNSCTQDIQTTKELCEFYDNFEESYGNLVLEAKRRKDVANRMKTILKDCEKQLQNLDAQDQEERQNFIAENGTYLPETIWPGKIDDFSSLYTLNYNVKNP
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MMDLSPNNQIEDRKPILTADGLVQTSNSPFEPTISQETQTSNGIGGQCHLTVDQLDIEILPIIYDIVRCVEKDPLENAVKLRESQDCNHKIFELQKRFESAREQIRQLPGIDFNKEEQQQRLELLRNQLKLKQQLIRKYKDTEF
The following text describes a protein:
Function:
Binds to all microtubule populations.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle.
Sequence:
MATYAAFKHVELYNVGKAKKRVLRAPGGGSSDIFGSDMPQTPRNVKNRMASNIFSADKDAAQKNNVRQGAHRFYFIGDAPRRGQKPVDSYSRLFGEPARPITPGKNHMKSSIPFGQNTNAAQQLLANNKGKYNGKSGSVSSASSSVSSSTENLKINVGNRSDGNPVTGEGYKAGGNDYIQPTAAMNGGNQVINKNRVPPGGYSSGLW
The following text describes a protein:
Function:
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
Subcellular Localization:
Nucleus.
Sequence:
MSEQRVFKHPCQFLTWNSKHNYIVCCSGPYLLGFSCSTGEKIFEHCYRDNINEKHREAAAYGEAIRQVAFSKDYSRMATVSEDKCLRLWDSTQPDKIELLYQKNIPKRCADLCFAGSNEIVFGDKFGDVYCVDENWFTTSEVTEEKKSNVVEGKQEPVNNDTLKDSKLQKLEPIMGHVSILTQLIVAQNPQNSKEEIIITSDKDEHIRISRFPNAFVIEGFCLGHEDFVSRMSLYDNRTLISGGGDNHVFVWDLENFKCLDAFDLRSAFSTYLSLNQPMVVSVILPIFKRQLVAFACEGMAGLIFAKVTPEKRLLFHSALKLSGPVLDAVLLDTDTDQILISLDSSFTFGACFECVKFDEGNAAVLTKPDVIKRIESDGLISTEKPFCPLAQIHTLRKNHSKFIRSVETGTSSPSVESKDN
The following text describes a protein:
Function:
Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MYEKEAKQQEEKIEKMRAEDGENYDIKKQAEILQESRMMIPDCQRRLEAAYLDLQRILENEKDLEEAEEYKEARLVLDSVKLEA
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVNPDAADEDSDDLDAEDADEDLEDEDLEDEADLEDDAEVSGEEDQDQGTDEDEADEPELASDDEGDAAEQADAQQMTERSKTSRKPLSRGAALLNDEVFDLDEMNAFLLAAERQAEGAPKRRSRKSADDDDDEDEEEDDDEVDLFAADDDEDEDEEDADADNVTGLLGRDYFKPPSADAPAKSKRAQATVASEESVESDPEAHEDEDQGADEDMAEEEDAVYAEEEFSDQERDAVDDEEDDASTGAADLLADSDDEEQANQEESRARVRPENSLLEEDLDFEHATAPAPEITQESTANLEDVIKKRIAEGLFDDVEPKTEGLDQMKERRHLVELDSEKSKQGLADVYADEFQQAATGRDTKKEALESKHAEIERLFQSLDRKLTALTNFHYTPAQPEEEVTVLSTAPALAMEDVTPVAFSSAQRLAPEELHAAERPEQVADGERTDTDRARARRKKKSVKHYERLDREQKDRLKDQNKVAESTTSAKKRAMTKLKQASTSGRSNTTFVDGQGASKAKLTSSTTFFRELQATAKREAQALMGQASGGAQMPTAKRSKKKGGDTAKFRL
The following text describes a protein:
Function:
Multifunctional protein that plays a role in the replication and long-term persistence of the viral episomal genome in dividing cells. Binds to mitotic chromosomes via its N-terminal region and to a 16-bp imperfect palindrome within the origin of replication (oriP) located in the viral terminal repeat (TR) through its C-terminal. Tethers viral episomes to chromosomes during mitosis. Plays a critical role in the shutdown of lytic gene expression during the early stage of infection by interacting with host TRIM28. Also plays a role in the repression of host NF-kappa-B activity upon TNF-alpha stimulation by promoting the proteasomal degradation of host RELA. Promotes nuclear localization and cleavage of host STAT6 leading to constitutive activation of the IL13/STAT6 signaling pathway to promote viral latency. Interacts with and modulates the histone methyltransferase MLL1 complex activity, leading to its recruitment on viral DNA terminal repeats changing the dynamic of histone H3 methylated 'Lys-4'(H3K4me) profile during the initial hours following infection.
Subcellular Localization:
Host nucleus. Note=Colocalizes with viral episomes on host chromosomes.
Sequence:
MAPPGMRLRSGRSTGAPLTRGSCRKRNRSPERCDLGDDLHLQPRRKHVADSVDGRECGPHTLPIPGSPTVFTSGLPAFVSSPTLPVAPIPSPAPATPLPPPALLPPVTTSSSPIPPSHPVSPGTTDTHSPSPALPPTQSPESSQRPPLSSPTGRPDSSTPMRPPPSQQTTPPHSPTTPPPEPPSKSSPDSLAPSTLRSLRKRRLSSPQGPSTLNPICQSPPVSPPRCDFANRSVYPPWATESPIYVGSSSDGDTPPRQPPTSPISIGSSSPSEGSWGDDTAMLVLLAEIAEEASKNEKECSENNQAGEDNGDNEISKESQVDKDDNDNKDDEEEQETDEEDEEDDEEDDEEDDEEDDEEDDEEDDEEDDEEEDEEEDEEEDEEEDEEEEEDEEDDDDEDNEDEEDDEEEDKKEDEEDGGDGNKTLSIQSSQQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQEQQEEQEQQEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQEQELEEVEEQEQEQEEQELEEVEEQEQEQEEQEEQELEEVEEQEEQELEEVEEQEEQELEEVEEQEQQGVEQQEQETVEEPIILHGSSSEDEMEVDYPVVSTHEQIASSPPGDNTPDDDPQPGPSREYRYVLRTSPPHRPGVRMRRVPVTHPKKPHPRYQQPPVPYRQIDDCPAKARPQHIFYRRFLGKDGRRDPKCQWKFAVIFWGNDPYGLKKLSQAFQFGGVKAGPVSCLPHPGPDQSPITYCVYVYCQNKDTSKKVQMARLAWEASHPLAGNLQSSIVKFKKPLPLTQPGENQGPGDSPQEMT