lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Responsible for physiological and behavioral changes in mated female flies.
Subcellular Localization:
Secreted.
Sequence:
MWRMRMRLLTGYLVLLALGQLPEHGALGQKYYMNFAFNNNNPDGEGGTGVDGGGGGAGGGAAGPGGGTGDSPHSQEGDGSAATDNPNDDHATSADNSLATDGDAIGKKESGGGSDGKSDSKDSSGGNDATPANGHDDDNDDSDSKDAKDRQDKEEEAGQEGKRTDHSHHSSYEISIDDSFGGRYVRSIYESSESHGHSGSNAGSNQRDNGARESSQENQDAKEVASEAPAQRAGNVPDGPETGAKEDDYEEM
The following text describes a protein:
Function:
Antiporter that exchanges dicarboxylates and sulfur oxoanions across the inner membrane of mitochondria. Exports alpha-isopropylmalate from mitochondrial matrix to the cytosol, where it serves as a precursor for leucine biosynthesis.
Miscellaneous:
MISCELLANEOUS: Present with 5350 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSSDNSKQDKQIEKTAAQKISKFGSFVAGGLAACIAVTVTNPIELIKIRMQLQGEMSASAAKVYKNPIQGMAVIFKNEGIKGLQKGLNAAYIYQIGLNGSRLGFYEPIRSSLNQLFFPDQEPHKVQSVGVNVFSGAASGIIGAVIGSPLFLVKTRLQSYSEFIKIGEQTHYTGVWNGLVTIFKTEGVKGLFRGIDAAILRTGAGSSVQLPIYNTAKNILVKNDLMKDGPALHLTASTISGLGVAVVMNPWDVILTRIYNQKGDLYKGPIDCLVKTVRIEGVTALYKGFAAQVFRIAPHTIMCLTFMEQTMKLVYSIESRVLGHN
The following text describes a protein:
Function:
Involved in sporulation and affects the sphingolipid composition of the plasma membrane. Probably involved in endocytosis.
Miscellaneous:
MISCELLANEOUS: Present with 17000 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Localizes at eisosomes, structures which colocalize with sites of protein and lipid endocytosis.
Sequence:
MVKVWNIVLRLVVLLFLAGNTLLLILMIISGATDHYPVNRFYWVQGNTTGIPNAGDETRWTFWGACLQDKDGSDTCTSNLAPAYPISPVDNFNTHINVPHQFISKRDAFYYLTRFSFCFFWIALAFVGVSFILYVLTWCSKMLSEMVLILMSFGFVFNTAAVVLQTAASAMAKNAFHDDHRSAQLGASMMGMAWASVFLCIVEFILLVFWSVRARLASTYSIDNSRYRTSSRWNPFHREKEQATDPILTATGPEDMQQSASIVGPSSNANPVTATAATENQPKGINFFTIRKSHERPDDVSV
The following text describes a protein:
Function:
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.
Subcellular Localization:
Cytoplasm.
Sequence:
MKNIIENYIKDLQKKNLSKNTLEAYRRDVEKFSEFVRNREERILSVDTVTIMAFVQYLQREGRATSSIVRNIVSVRNFYKYLIKKNMVSEDPTLGYEIPKIERTIPKILSVEEVDKLLNSPNSSKKGLRDKAMLELMYATGVKITELLNLNIYDINLKFNYIKCRGSKKRERIIPIGSYAIKCLKNYLEVRPAINVYNLDYLFLNLKGTQMTRQGFWKIIKFYAKEASIDKEIDSYTLRHSFAVHLLQNGADIKSVQELLGHKDLAATQIYSSISKKSKIAEVYKNAHPRA
The following text describes a protein:
Function:
This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
Sequence:
MAPSVQDNRSASPQSDKGAKTKAPQITTSSPAFPFPLSADIASVAGTSNLTGQALVEQTAYALSKALFSYSPESFDLDRAVKTWNAKDQTNGAGKVPYFVELESRVGAAAILLGYIYNQTGSNAPSGAQSVLASSATLKLMAPVLATYSAKPTASSPLAFNIAAVDYDHDAEQLVTDYSSVFEVARSIGLGLVSSTKPSEAQNMTVLATLLSIANPTVHVYDGLHFLRQTSRVSDIKATKAVYDLYSSLVDSSNASVAAVLDNFNAAVGTSYKAFEYEGAADAKQVYVVFGSAEAEAAREILPKSAGLIVVRIYSPFLEAEFLKTLPKTTESITVVGQVQNSVAVESAYEHSLLFADVSGAIAFSADFGRVKVHEVKYARSLEIDGLSLGDLLGIETTPKPHYTFFNLDNAATANTAAATAHVLALDKAAVTYYSEYDNYTAGGVVKTTISTDRAIPKSLTVVSDLSIVRSLNVTAPETDLLLVGSSKQEDLDKALTDSFKLSVALSGAAVHIVDPSIVGDNAETSGRTESMIEQLAFWKLAHPELSLDQITTKIVQANGVDTELVASTVAKLAETVYESALTEINTEGWGTVEGETELEVPPYFTVNAFGPANVRGEDEEGGAAAASISEAAKRVVFKEAYGTENSLRPDISTKNFVVKVQEKRRVTPENYDRNIFHVEFDITGTGLKYEIGEALGVHARNNAELVDQFIESYGLNPNELVSIRNSEDSSLSETRTVLQICREHLDLFGKPPKRFYEALAPFATDAAEKAALEKIASPAGAEELKKRSEVDTDSFVDILAEFPSARPTIADLVQIVAPLKRREYSIASSQKVHPNAVHLLIVVVDWVDPKGRKRFGQASKYINDLKVGEELVVSVKPSVMKLPPLTTQPIIMSGLGTGLAPFKAFVEEKAWQREQGHEIGDVYLYLGSRHKREEYLYGELWEAYKDAGVITHIGAAFSRDQPQKIYIQDRIRQSMPDLVDAFVKKEGGFYLCGPTWPVPDVTQVLSEIIETEAEERGEKLDSARAIEELKDAGRYVLEVY
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKPKRKSGKSFSKASAKVNGKAPERTNPFEVKVNKQRHDVLGRKSKNDRGLPGVSRSKAIKKRNETLLQEYVLRNKSSAFVDKRIGEFDSEMNPDDKMAARLAQERKILQKKSVFSLNEEEELTHLGKSINDMERHDDPRSDDEDLYDKLGRDFADKTNFGGFLTKADPSSDSAKSRKEAIDQLIAESKKLKYERQVQKDENFELTERLDNDWKQFQGLLASSRLKKKPTEAEKESTDDYDVLVKQLRFAPRAGTATERVKTADEVAKEERKQLEKLELERKLRAKGITERDSKKQWYFLSADDLDYNFYKQEPVTEDADMSGDEEEDAEEEGSGGDDEAEDKSASEGDDESGAESVEEIEQDVSGKEQAARQEDKSDDDDDDGYSDLESDDDGSLQKETPPVAKGKAKEAPKTSVIKTCKKLQSKAASEKEGGKPVSKAVPEKKESRPTCIVTIPESEEEFSKLMADNTADEKACFVGDMIKANQGGEKKLKKLEMLFVFLLQHLNDVADEDLELVDKLCPHIYALVQISPTTCGRFLLDVISEKEEDLQKATERRARFGISFPSFSTLVFLKIVGQCYSASDFSHIVATPAMLSASHMLTCCGLNGAADFLRGLFVTNVFLEYIAYSRRFSPEVFVFLERLLSHRELKLKKRADASGLLHEKLKLRLLGEEDVEMTDQLRVEIIYAGVKLVEKCAELSEGLPSFRELVDPLLKTLRKLEVSAYPPTVQSEVEKVISRLDRKVERKPLRPEKRPPPMKQLLEPRFSMKFDGRKHFEGGQKKAELKRLTYKHKKEMKGAMREVRRDNQFLARHILKDRIERDAERKEKVKQIYRELASQEGEYKALKRKKK
The following text describes a protein:
Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Sequence:
MYFNYKSVCGSCGFGSCYGCGYGCIHSTHCGCNGYYGCYENKYSVIDDLIFFASKKCH
The following text describes a protein:
Function:
Binds directly to 16S ribosomal RNA.
Sequence:
MANHKSSLKRIRQEETRRLHNRYYGKTMRNAVRKLRATTDKKEAVAMYPGITKMLDKLAKTNVIHKNKANNLKSKLALYINKLA
The following text describes a protein:
Function:
Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA.
Subcellular Localization:
Nucleus.
Sequence:
MYQPPLPPPPVQPAPPPPPPPPEEDLSPPGVGVPSHNYSSNESHSQSSKSLDYVYPETPAPYASSVPSYDPYQQPPAYGYEGYAYNEQAQKYGGQESHYQYQYPASGSSFLYESYKYPDRYPAYSSNYRPPSERQRYTSNSSSQGYHHYPGYSSGRRYEQRHDQEHRQIQDSRYAHEPRHGHYAHRQAKGSQHGYYGSAARNQVSDDYSPRGHHERERNETLEKTRAKPKVETERDRLLRQWCSNFCEKPEDYVKKMNALSEADAPVESWVRSSPAELYYERTKSENEVRGRARLQKLCTLFDEELLQRAKRVREKLPVYVPPPRKARRRVCKHKHKSEACSSSSSSDDDSDEDAFKIEQDCCMEELSRKVQHPQRVHADLWHNDAGEMNDGPLCRCSAKSRRIGIRHGIYPGETGYKLCDPNSNNAGKLFHYRISISPPTNFLTKTPTIIKHDEHEFLFEGFSLLSHVRLSDLPVCKVIRFNIEYTIEYEEEKMPENFTIHELDIFFKYLFHELLELVDFNLMPNLPSGNVEESCPAFHFFPRFVRDLPDNGKEVLAMVEVLRYLLDNSAQLVERQQLLHLNQISQSEWQNYVDFIKGMLVTKPGYKPCSLRVDQLDRNNSDLPECVDRETGISHPAIVHFGICHPQLSYAGNPEYQKAWREYVKYRHLMANMSKPSFKDKRKLEEKEQRLQEMRTQGRMKRNITVAISSEGFYRTGIMCDVVQHAMLIPVLTGHLRFHKSLDLLEESIGYRFKNRYLLQLALTHPSYKENYGTNPDHARNSLTNCGIRQPEYGDRKIHYMNTRKRGINTLVSIMSRFGKEHETVSNITHNERLEFLGDAVVEFLSSIHLFFMFPELEEGGLATYRAAIVQNQHLALLAKKLQLEEFMLYAHGSDLCHELELRHAMANCFEALMGALLLDGGIKVADEVFTDALFRQDEKLLSIWKNLPEHPLQEQEPLGDRSCIDSYRVLKELTKFEDSIGIKFKHIRLLARAFTDRSIGFTHLTLGSNQRLEFLGDTVLQLICSEYLYRHFPEHHEGHLSLLRSSLVNNRTQAVVCDDLGMPKYAVYANPKADLKTKDRADLLEAFLGALYVDKGLLYCEQFCHVCLFPRLQLFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPYYKVVEASGPTNTRVYKVAVYFRSKRLATSSGSSIQQAEMNAAKQALENSRDLFPQLDHQKRVIAKSIKKQTGNELDNDSDRQHQEEKIKRPKYATPLQDESHLPKQYRMHENISSDELPEDEDFESTAPKSPTMPLRSNRSGSSSSSSSSDSDGSTSSPKCKRRLKKCSSVSSKSSLG
The following text describes a protein:
Function:
Probable transcription factor that involved in boundary specification, meristem initiation and maintenance, and organ patterning. Functions in both lateral organ separation and axillary meristem formation.
Subcellular Localization:
Nucleus.
Sequence:
MEMVHADVASLSITPCFPSSLSSSSHHHYNQQQHCIMSEDQHHSMDQTTSSDYFSLNIDNAQHLRSYYTSHREEDMNPNLSDYSNCNKKDTTVYRSCGHSSKASVSRGHWRPAEDTKLKELVAVYGPQNWNLIAEKLQGRSGKSCRLRWFNQLDPRINRRAFTEEEEERLMQAHRLYGNKWAMIARLFPGRTDNSVKNHWHVIMARKFREQSSSYRRRKTMVSLKPLINPNPHIFNDFDPTRLALTHLASSDHKQLMLPVPCFPGYDHENESPLMVDMFETQMMVGDYIAWTQEATTFDFLNQTGKSEIFERINEEKKPPFFDFLGLGTV
The following text describes a protein:
Function:
Histone demethylase that demethylates di-methylated 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (By similarity). Plays a role in the mitotic development of the germline. May be involved in H3 demethylation in mitotic cells including gut and embryonic cells. Plays a role in sensitivity upon interstrand cross-link DNA damage, probably by positively regulating the expression of mlh-1. Plays a role in developmental growth and lifespan regulation in response to ultraviolet-induced damage. No obvious role in larval development, sex chromosome segregation or for regulating meiotic crossover frequency.
Subcellular Localization:
Nucleus. Note=Only localizes to 5% of premeiotic tip and pachytene nuclei.
Sequence:
MTTELEIDDRKEEEAQIPGETSESEEGDEPVKMNRVKRACAMAAESLKEAKRIKNMLMEEECVLQLGNCKKTASYGHRLSKTEACCPSCFSVAFRGKDYENEFTIWKQKAMDGQTHVRSEQFVKRYVNSCFLPYYAKCHQCSKYSKLITSDSLSAQQLSDFKCDCASTIESPKIERVREDSEWCFNEFGHPPLLQNNISYDLLVDHYVTRTTGMDATCQEKAALIDNGGIEFRDTRRIMNMFYVPFTDVIANIVHPEFMETDEKFAFPKFADDPISIYYLQVRNTIIAMWLKHPFVELTVKMIEPQIIVRGHARIFFIEHLIHPILEFLTIKGVVNYGAFDFRIDPLNGMRPKIAIIGAGISGISTARHLKHLGIDAVLFEAKDRFGGRMMDDQSLGVSVGKGAQIIVGNINNPITLLCEQIGIKYRNSNFFCPLIDENGRCFTLERKELDDQVDLHYNNVLDAIRNKYQSDRNFPDVPLEVTNFRHFTEMFSKMSSGLLSAADLDSLYTPEFEKLLDFHLGNLEFSCGTHVSNLSAKDYDHNEKFGNFAGEHAVITDGAQRIIDFLATGLDIRLNCPVKCIDWGRDDRKVKIFFENAEQAAEEFDKVVITTSLSVLKSNHSKMFVPPLPIEKQKAIDDLGAGLIEKIAVKFDRRFWDTVDADGLRTEYFGKVSDCKTDRSLFNIFYDFSGKDPNGEDTFVLMSYVTAEHVNLVNVLTESEVADKFCATLRKMFPSAVINPLGHMMSHWGADRFVGMSYTFVPFGSDGDATYNQLKKSIDEKLYFAGEHTIAAEPQTMAGAYISGLREAGQIVMSLKRDSATFE
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
AKMAVDMELRKAFSDLQMKMVDTQNQMRISDGQINAMMVEKKKTELAISEVSSVPEDAKMYESVGRMFVLEPKATVMKNLEAQHKLTDTKIKELEAKKLYLEKSVKSSEENLREMVLQRRK
The following text describes a protein:
Function:
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAKAGMIIQRVVLNSRPGKNGVPVAENFRLEQSTIPDTVQEGQVRVRTLYLSVDPYMRCRMNEDTGSDYLLPWQLSEVADGGGIGVVEESKHHNFAKGDIVTSFNWPWQTVAILDGSLLQKVVPELVNGRLSYFLGAAGLTGLTALLGIREKGHVTVGANQTMVVSGAAGACGSLAGQIGRLEGCSRVVGIAGTDEKCSILVSEMGFDAAINYKTGNVAQQLRELCPGGVDVYFDNVGGDISDTVISQMNQNSHIILCGQISQYNKDVPYPPPLPPGTEKIQKERNITRERFLVLNYMDKQEASILQLCQWIQEGKLKVRETVVEGLANIGAAFQSMMNGGNIGKQIVLVSK
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center.
Sequence:
MLHELLLALVGCTGDVFVDTHSEAHKLGRPNSSILDEATLAEPASCPIKLAPDIDFVSESERSVLNRLVWLGYLYRELELFSSHEQGIGTDALGQPDRDGGGSMYQRALATGLAEVLAVYRSAILQLEQDALSETAPVLSTVTQAMHQFEVVLPPLASLVWAVQRGGVKGGALLDLLYAKSHSGVPPLQACMQRLLWHCHCVLYRQLAGWMVHGLLHDPHAEFFVARHDSGRVRRRESVDTTGKAGQGPPRAEDDAMHDWHSGFTIRTPMLPSYISLPMAEAILFVGKAVRVLRHPSVSFTSQAVPPLQAAPPLLLRSSGGTPSRRIASPAPPAAHSPSKLRLPSAGYQGPELLPQAEADKYGARIRELQAAPVFHRPSLEKVVHTVRAGAAHHLWQLLVVHADVRGHLRALKDYFLLAKGDFLQCFLEESRALMRLPPRPTTAEEDLRVPWQQAASKTINEDDVYFQRVSVRLPGLAAATVAAGTAGAGALRRLSGASSVGSPGPGGAAEGGGTGPDGWDALALQYHVEWPLQLLLTPEVLAKYKSVFQYLVRLKRVQLALESAWATAMQRDKADTAALLRPHAALPPGARQAAADRQRGRRTMWRVRQHMSYLITNLQFYIQVDVIEAQYAVLQERIEASKDFEDLARFHQEYLLALMSQSFLDVGSIWRILDGIMALCWQLAGLLDHDDVTGGGLDGIAEEFAKRSNSLYTILRSPKLAGSQRAPFLRQFLLRLNYNSFFEATARGAIGLLRPRTASFTAPQR
The following text describes a protein:
Function:
Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity).
Subcellular Localization:
Secreted, extracellular space. Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.
Sequence:
MGVKAAQTGIWASQGQSIRVVGFQAQTAHRAICLLGFVVLVLLQCCSAYKLVCYYTSWSQYREGDGSCFPDAIDRFLCTHIIYSFANISNDHIDTWEWNDVTLYGMLNTLKNRNPNLKTLLSVGGWNFGSQRFSNIASNTQSRRTFIKSVPPFLRTHGFDGLDLAWLYPGQRDKQHFTTLIKEMRAEFIKEAQPGKKQLLLSAAVSAGKVTIDSSYDIAKISQHLDFISIMTYDFHGAWRGTTGHHSPLFRGQEDASPDRFSNTDYAVGYMLRLEAPASKLVMGIPTFGRSFTLASSETGVGAPISGPGIPGRFTKEAGTLAYYEICDFLRGATVHRILGQQVPYATKGNQWVGYDDQESVKSKVQYLKERQLAGAMVWALDLDDFQGSFCGQDLRFPLTNAIKDALAAT
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Miscellaneous:
MISCELLANEOUS: Present with 937 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDKEVSELVVLQLIHTLISNKNEELVRNGGGINMIGNNLRISLVKLTNEIQNNLLINELTNLRRQSNVANGNRKLGINDILTIVKNLFPEYRTTLNDGQLSLHGLEMHDIEKLLDEKYDRFKKTQVEQIRMMEDEILKNGIKTGASQLQPHANAGKSGSAGTSATITTTTPHMAHSMDPKREKLLKLYRDTVLNKLESKTGNFQKLFKSPDGSIIKNEINYEDIKNETPGSVHELQLILQKSITDGVMRKVIGTDDWKLARQVQFELDDTVQFMRRALE
The following text describes a protein:
Function:
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKAAL
The following text describes a protein:
Function:
Enzyme that cleaves trehalose to produce 2 glucose molecules that can be used by the glycolytic pathway (Probable). Glycolysis is essential in glial cells but not in neurons; neurons rely on the citric acid cycle for their energy needs, and on lactate and alanine secreted into the hemolymph by glial cells to fuel it.
Sequence:
MFKLPTISLLLVSWSCLVALSQAKTYSLPDLTTDYNNAIPVDEEEAQDPFASCKIYCEGNLLHTIQTAVPKLFADSKTFVDMKLNNSPDKTLEDFNAMMEAKNQTPSSEDLKQFVDKYFSAPGTELEKWTPTDWKENPSFLDLISDPDLKQWGVELNSIWKDLGRKMKDEVSKNPEYYSIIPVPNPVIVPGGRFIEFYYWDSYWIIRGLLYSQMFDTARGMIENFFSIVNRFGFIPNGGRVYYHGRSQPPLLTGMVKSYVDFTNDDKFAIDALDTLEHEFEFFVNNHNVTVKNHSLCVYRDSSSGPRPESYREDVETGEEFPTDEAKELHYSELKAGAESGMDFSSRWFISPTGTNDGNRSALSTTSIVPVDLNAYLYWNAKLIAEFHSKAGNTKKVTEYETKAEKLLLGIQEVLWNEEAGVWLDYDMINQKPRDYYTPTNLSPLWVKAFNISESEKISASVMAYIERNKLDSFPGGVPNTLSYTGEQWDAPNVWAPMQYILVEGLNNLNTPEAKNMSLKWATRWVKTNFAAFSKDRHMYEKYNADEFGVGGGGGEYEVQTGFGWSNGVIIEWLSKHGRDISIGSGCGCLAGEKRQ
The following text describes a protein:
Function:
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.
Sequence:
MISIAFRFYFLHSNCRSFQFKSRYDASAQTNCIECCPFETAHDLILFATESTIEVLRVSPDNSHSNHPVFTEIQKFPIGSNVTCLGWSKHSLSRLLDDGYETKIVFAASFEDRSILLYASGYSPVDVCRAPQMRHQNTINAIAFDKANGHFIASVGDDNTCRIWTIADLSAEESDTYPIVMQLKSRGVSVCTHEKVANQVLVGEASGAIRILNIESQTWMFSVFHPDRSIPEPLLRCVDWNPLDPNILGAAIGKKWHVWSLKGEKSIHLPEHSGDAHIEIAHRFKWCLSDPKMFLTSTNSPEASNTQRVAIKVFSNVYTQIPNTITLLSKSRLTSVGWLASSKNIVGTVGKQIVLWYVE
The following text describes a protein:
Function:
Required for arbuscular mycorrhiza (AM) development during AM symbiosis with AM fungi (e.g. Glomeromycota intraradices).
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MADQKPVKWLVLILTNCLFFSIAFSAKTQFAHKTYIVQMDKSAKPESFTNHLDWYSSKVNSIVFKPENEEDGGHDQERVIYTYQNAFHGVAARLSEEEAERLQEQDGVLAIFPDTKYQLHTTRSPLFLGLEPHDSTTTVWSQRVTDHDVIVGVLDTGVWPESQSFNDTGMSPVPAYWKGACETGRGFSKHNCNKKIVGARIFYHGYEAATGKINEQTEFKSPRDQDGHGTHTAATVAGSPVRGANLLGYAHGTARGMAPGARIAAYKVCWVGGCFSSDILSAVDKAVADGVNVLSISLGGGVSAYYRDSLSIAAFGAMEMGVFVSCSAGNGGPDPVSLTNVSPWITTVGASTMDRDFPSSVKLGNGRTVTGVSLYKGRMMLSTNKQYPVVYMGDNSTSPDPSSLCLEGTLDRRVVAGKIVICDRGISPRVQKGQVVKDAGGVGMILANTAANGEELVADCHLVPAVAVGETEAKAIKHYALTSPRATATLAFLGTRTGVRPSPVVAAFSSRGPNFVSLEILKPDVVAPGVNILAAWTGALGPSSLPTDHRRVKFNILSGTSMSCPHVSGIAALLKARHPEWSPAAIKSALMTTAYVHDNTHKPLQDASAAEASTPYDHGAGHINPRKALDPGLVYDIEAQDYLEFLCTQRLTPMQLKVFTKYSNRSCKHALASPGDLNYPAISVVFPERTNVSLLTLHRTVTNVGPPVSNYHAIVSPFKGAYVKVEPRTLKFTRANQKLSYKITFTTKSRQATPEFGGLVWKDGVHRVRSPIVVVWLPPL
The following text describes a protein:
Function:
Plays a role in the catabolism of L-fucose. Catalyzes the NAD(+)-dependent oxidation of 2-keo-3-deoxy-L-fuconate to 2,4-diketo-3-deoxy-L-fuconate.
Sequence:
MAADRTAAGTAVRRRQCRGGVRRQRTHVLSSATAGGPHPRNLIGMTVSIPTTPNTRLQGKRCLITAAGAGIGRESALACARAGAHVIATDIDAAALQALAAESDAITTQLLDVTDAAAITALVAAHGPFDVLFNCAGYVHQGSILDCDEPAWRRSFSINVDAMYYTCKAVLPGMLERGRGSIINMSSVASSIKGVPNRFVYGVTKAAVIGLSKAIAADYVAQGVRCNAICPGTIKTPSLGQRVQALGGDEQAVWKSFTDRQPMGRLGDPREIAQLVVYLASDESSFTTGQTHIIDGGWSN
The following text describes a protein:
Function:
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Subcellular Localization:
Cell membrane. Late endosome. Early endosome. Note=Interaction with EGFR may enhance association with the cell membrane.
Sequence:
MIPANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLLEKLRKAQDFYVEMKWEFTSWVPLVSKICPSDTYKVWKSGQNLRVDTTLLGFDHMTWQRGNRSFVFRGQDTSAVVMEIDHDRRVVYTETLALAGQDRELLLAAAQPTEEQVLSRLTAPVVTTQLDTKNISFERNKTGILGWRSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKVKGCKTPLQSFLGIAEQHGGPQNGTLITQTLSQANPTAITAEEYFNPNFELGNRDMGRPMELTTKTQKFKAKLWLCEEHPLSLCEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITFGNLNGCDEPVPSVRGSPSSETPSPGSDSSSVSSSSSTTSCRGCEISPALFEAPRGYSMMGGQREAATRDDDDDLLQFAIQQSLLEAGSEYDQVTIWEALTNSKPGTHPMSYEGRRQDRSAPPTPQRQPAPPASVPSPRPSSGPGSGGHVFRSYDEQLRLAMELSAQEQEERRRRARQEEEELERILRLSLTEQ
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MGVVVFGKSIKHNFPVRIGLAKTIFGIGYQTAERLMAKVGIYPNCRMNQLTEPQIMDLNKEISQLLVEGHLKHKINNDIKMKRTIGSYAGSRHALGFPVRGQRTKTNGSTARQLNRTERFRL
The following text describes a protein:
Function:
Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MKHQRGYSLIEVIVAFALLALALTLLLGSLSGAARQVRGADDSTRATLHAQSLLAVQGMEQPLVPGQQQGSLEDGHFRWSLDVRPYDEPRRNAQAPVDPSAPTLLQLTLVVRWGEQPNQRLLWRTLRLVTATAQGNPA
The following text describes a protein:
Function:
Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity).
Domain:
The heavy-metal-associated domain (HMA) coordinates a Cu(+) ion via the cysteine residues within the CXXC motif. The transfer of Cu(+) ion from ATOX1 to ATP7A involves the formation of a three-coordinate Cu(+)-bridged heterodimer where the metal is shared between the two metal binding sites of ATOX1 and ATP7A. The Cu(+) ion appears to switch between two coordination modes, forming two links with one protein and one with the other. Cisplatin, a chemotherapeutic drug, can bind the CXXC motif and hinder the release of Cu(+) ion.
Sequence:
MPKHEFSVDMTCEGCSNAVTRVLNKLGGVQFDIDLPNKKVCINSEHSVDTLLETLGKTGKAVSYLGPK
The following text describes a protein:
Function:
Component of the dammarane-type triterpene saponins (e.g. PPD-type ginsenosides or panaxosides) biosynthetic pathway. Glycosyltransferase that catalyzes the conversion of ginsenoside Rh2 to ginsenoside Rg3. Triggers the biosynthesis of ginsenoside Rd from ginsenoside F2.
Sequence:
MDNQNGRISIALLPFLAHGHISPFFELAKQLAKRNCNVFLCSTPINLSSIKDKDSSASIKLVELHLPSSPDLPPHYHTTNGLPSHLMLPLRNAFETAGPTFSEILKTLNPDLLIYDFNPSWAPEIASSHNIPAVYFLTTAAASSSIGLHAFKNPGEKYPFPDFYDNSNITPEPPSADNMKLLHDFIACFERSCDIILIKSFRELEGKYIDLLSTLSDKTLVPVGPLVQDPMGHNEDPKTEQIINWLDKRAESTVVFVCFGSEYFLSNEELEEVAIGLEISTVNFIWAVRLIEGEKKGILPEGFVQRVGDRGLVVEGWAPQARILGHSSTGGFVSHCGWSSIAESMKFGVPVIAMARHLDQPLNGKLAAEVGVGMEVVRDENGKYKREGIAEVIRKVVVEKSGEVIRRKARELSEKMKEKGEQEIDRALEELVQICKKKKDEQ
The following text describes a protein:
Function:
Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).
Subcellular Localization:
Cytoplasm. Note=Colocalizes with CheA chemoreceptor patches near the cell poles, which requires CheA(short).
Sequence:
MMQPSIKPADEHSAGDIIARIGSLTRMLRDSLRELGLDQAIAEAAEAIPDARDRLYYVVQMTAQAAERALNSVEASQPHQDQMEKSAKALTQRWDDWFADPIDLADARELVTDTRQFLADVPAHTSFTNAQLLEIMMAQDFQDLTGQVIKRMMDVIQEIERQLLMVLLENIPEQESRPKRENQSLLNGPQVDTSKAGVVASQDQVDDLLDSLGF
The following text describes a protein:
Function:
Catalyzes the hydrolysis of the N-glycosidic bond of all of the commonly occurring purine and pyrimidine nucleosides into ribose and the associated base, but has a preference for inosine and uridine as substrates. Likely functions in purine salvage from the host, a fundamental pathway since protozoan parasites such as L.major are incapable of de novo purine biosynthesis.
Sequence:
MPRKIILDCDPGIDDAVAIFLAHGNPEIELLAITTVVGNQSLEKVTQNARLVADVAGIVGVPVAAGCTKPLVRGVRNASHIHGETGMGNVSYPPEFKTKLDGRHAVQLIIDLIMSHEPKTITLVPTGGLTNIAMAVRLEPRIVDRVKEVVLMGGGYHTGNASPVAEFNVFIDPEAAHIVFNESWNVTMVGLDLTHQALATPAVQKRVREVGTKPAAFMLQILDFYTKVYEKEHDTYGKVHDPCAVAYVIDPTVMTTERVPVDIELNGALTTGMTVVDFRYPRPKNCRTQVAVKLDFDKFWCLVIDALERIGDPQ