lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Recruited to the cell membrane via the third C2 domain (By similarity).
Domain:
The SMP-LTD domain is a barrel-like domain that binds glycerophospholipids in its interior (By similarity).
Sequence:
MQPEEPCAPSAPGGPDVPERGQRSRDPGPRLSGQLLPELYSFVARVLFYLAPVYLAGYLGLSVTWLLLGALLWMWWRRNRRGKLGRLEAAFEFLEHEREFISRELRGQHLPAWIHFPDVERVEWANKIIIQIWPYLSMIMENKIREKLEPKIREKSIHLRTFTFTKLYFGQKCPKVNGVKVHTDKRNRRKVTLDLQICYIGDCEISVELQKIRGGVSGVQLQGTLRVILEPLLVDKPFIGAVTVFFLQKPHLQINWTGLTNLLDMPGINELSDSLLEDLIAAHLVLPNRVTVPVKKGLDVTNLRVPLPCGVIRVHLLEAKKLAQKDNFLGLGGKSDPYAKVSIGLQHCRSRTIYKNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDKDDFLGSLQICLGDVMKNRVVDEWFALNDTTSGRLHLRLEWLSLLTDQEALTENDSGLSTAILVVFLENACNLPRNPFDYLNGEYRAKKLSRFVKNKASRDPSSYVKLTVGKKTFTSKTCPHSKDPVWSQVFSFFVHSVAAEQLCLKVLDDELECALGVLEFPLCRILPCADLTLEQCFQLDHSGLDSLISMRLVLRFLRVEGRELGSPYTGPDALKKGPLFIKKVATNQGCKAPPLNEGLADVTSTSNPASYIKGASKSIDNISAATTDPEPMPEPQGPGPEPKGKDSARGLCESPGKKKNPATTFLTVPGLHSPGPIKSPRPMSRPAFPFAWPLTRVAPSMSSLNSLASSCFDLTDVSLNTEAGDSRQGRLGEIQLTVRYVCLRHCLRVLVNGCRNLTPCTSSGADPYVRIYLLPERRWASRKKTSVKQKTLEPLFDETFEFFVPMGEVQKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKQDLIKGFSQWYELTADGQPRS
The following text describes a protein:
Function:
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
Subcellular Localization:
Secreted, extracellular space, surface film.
Sequence:
MWQLLLLGLFSCGSAAAAWTSVEEGCAQGPVFWCRNLVTAIQCGALGHCMKSRWDPNTKEDLCADCKQVVSILVRMGKESALKVIQKSLEDECKDLPLQTLAPQCQALVDTYFAQFIGILEKQMAPGAVCAKLSLCPPDRSAGKEDALEALFAEIRGLLPPQKDRSLSWPHSQTQGVPEEGFPIPLPTCWLCRSFVGRAEALIPTAAIGTTMAQLCRVLPVSMGGMCQCLTEKYSATILDMVLGKVGPNLICGMMLMCATEDGSPDMPPAAPALDLSTDGCQACLAISSHVQGALQPNSTRVDVDLALLSACSRSFLGWEECKRFISQHQAQLFALLLKPWGSHAICQVGRHDSGW
The following text describes a protein:
Function:
Catalyzes both the 5'-exonucleolytic and structure-specific endonucleolytic hydrolysis of DNA branched nucleic acid molecules and probably plays a role in viral genome replication. Active on flap (branched duplex DNA containing a free single-stranded 5'-end), 5'overhangs and pseudo-Y structures. The substrates require a free, single-stranded 5' end, with endonucleolytic hydrolysis occurring at the junction of double- and single-stranded DNA. This function may be used for example to trim such branched molecules generated by Okazaki fragments synthesis during replication.
Domain:
Three alpha-helices form a helical arch which forms a hole in the protein and through which the 5' flap of the scissile ssDNA is threaded.
Sequence:
MSKSWGKFIEEEEAEMASRRNLMIVDGTNLGFRFKHNNSKKPFASSYVSTIQSLAKSYSARTTIVLGDKGKSVFRLEHLPEYKGNRDEKYAQRTEEEKALDEQFFEYLKDAFELCKTTFPTFTIRGVEADDMAAYIVKLIGHLYDHVWLISTDGDWDTLLTDKVSRFSFTTRREYHLRDMYEHHNVDDVEQFISLKAIMGDLGDNIRGVEGIGAKRGYNIIREFGNVLDIIDQLPLPGKQKYIQNLNASEELLFRNLILVDLPTYCVDAIAAVGQDVLDKFTKDILEIAEQ
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAKPTHSKGGPSSKERKLKMKVQPEEEEEDISSDDHNSEGAEEEEEDEDEDDEDYGSLTDESEDEWAEERKAIRYIAESELEDNLDSSSDDSDDQSDDPFLEPAARKMQSIGSLIKARQNNKQGMRSNEKKEEEEGTSKQKKKPQESEKSRRTNEMGSSGDEETIKKAYSTRKKSIAQRSHKHAPIEISSKKPVTRKRTIVEVPKIERRDPRFDSLSGQVNSELHERSFEFLKEQRKSELEQLRQTLALAKKKKSSSKLDPDQLEALENHIRKEENKDVQNQKLMWEKQALKEWKSQENAKRKEGKGAFYLKRKAQKEIILTNRYQQLSQNKSKLHKSIEKKRKKVDGKEKKSMPFKRHRPSD
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Sequence:
MGPKRRKPIPEEALAYIHRIACMQMNLSDAYMFLACLYSDDTTMTSFGAYSQDKASVKWFYAKRILAYITERGNKVCIPEIQRPEIDTQGCIQCAIDILNMENELTEILHDLQDVALTVKDNTTITFTKELIYTQRRNEDRLALEIVELRRKEKLAQEEDDKNKRRLKGTRKKPRR
The following text describes a protein:
Function:
Component of the male-specific lethal (MSL) histone acetyltransferase complex, a multiprotein complex essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). The MSL complex specifically associates with the single X chromosome in males and mediates formation of H4K16ac, promoting a two-fold activation of X chromosome. Acts as a histone reader that specifically recognizes and binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and histone H4 monomethylated at 'Lys-20' (H4K20me1). Within the MSL complex, mediates the spreading of the MSL complex from initiation sites on the male X chromosome to flanking chromatin. Following initial recruitment of the MSL complex to male X chromosome by msl-2, msl-3 binds H3K36me3 and promotes spreading of the MSL complex in cis. In addition to its role in dosage compensation in males, promotes germline stem cell differentiation in females: recognizes and binds H3K36me3, promoting recruitment of the ATAC complex and transcription of genes, such as RpS19b.
Subcellular Localization:
Nucleus. Chromosome. Note=Msl-3 is associated with hundreds of discrete sites along the length of the X chromosome in males and not in females, and is also associated with 10-20 autosomal sites in males. Recruited to the male X chromosome following association with roX1 and roX2 non-coding RNAs.
Domain:
The chromo domain specifically recognizes and binds histone H3 trimethylated at 'Lys-36' (H3K36me3). The chromo domain also mediates association with roX1 and roX2 non-coding RNAs, promoting recruitment to the male X chromosome.
Sequence:
MTELRDETPLFHKGEIVLCYEPDKSKARVLYTSKVLNVFERRNEHGLRFYEYKIHFQGWRPSYDRCVRATVLLKDTEENRQLQRELAEAAKLQIRGDYSYKGTPDKPSAKKKRGGKAAHVEEPIVVPMDTGHLEAEHEMAPTPRAAGNRTRDNSGGKRKEKPPSGDGRLKGNRGRQTETFYNNAINDVSVYNHVPQEDRIMMRVSERLRELIEYDRNMIKVLGKQHALPARVPIVTIMENFVKQQAVELAISIKQDSSRARNTQSRNARMEREYDRVMSTVCMLKEVVDGLRIYFEFHVDDHLLYTEEKEYVHNYLTDDNMRNCSLILNKSYEYINPSGDTELIGLDGTPVVEGSGDTNGQIGVINIGGPEYEKQLQKCLLYIVTASGKNTAQAYERTSPYTAAYKLPVEMRGFLNETFKWRLLSAESPPEKSMVFGAPHLVRLMIKMPMFLNASPISNKKLEDLLPHLDAFINYLENHREWFDRENFVNSTALPQEDLQRELLDSLDGIAA
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MSQKIGQSGLAFARLWHHVDVAREQRTLGRLASSIAITLMGKHKPVYHPSMDCGDYVVVTNAQDLQVTGKKWEQKTYWSHSGRPGHLKLRTMETIATNKGHSELLRKAVSGMLPKNRLRKVRLARLKVFDGSEHPYKQNIVAFADEQAEQPARPSA
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MTFFYAAAAGCSFLAFSYLLLRTRGLRFAAMSVGVGSAIGALLVYLNNKQTHSFIAVRKSSSLLFSPGNFKAIYQRIYEHLNDQYEERGQLEAGEEILTVKPNVFAQNGVIDFDGVRKMWTSHIVPQLRRCVTGDHLANTTDNSVVSIEESAVFCDIGSGVGNVCLQLLAETNCRKVVGVEVIPSRHRAATTAFAKALSYFPENFSGKQAIFIQDDFVNCARRMVEENVNVIFTHSWMFDDELMKRLTELVVSLPALLCVVTSRPLHENLLVGSQMKLVSYVHLTADWNDEAPFFIYRKIT
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MAAVACCWSYLVVVATVVLPLLLLGVIGVSRAQLLQVGFYSDSCPDAEATVAAAVQDAAANDPTILPALLRLQFHDCFVKGCDASVLIRSASNDAEVDNGRNQGLRGQEVVDAAKAQLEDQCPGVVSCADIIALAARDAVAMTGGPSFDVPTGRRDGLTSNLRDADVLPDAGDSISVLRSRFAASGLDDRDLVLLTGRYSNSTLHVYTWPAIFTNDTGRSGAHGGHDGVLLREGPAVRLPAAGRREGGGPFDPGAVPGGAQGPVPAGQPQRAAAAGPRQRERLRRLHPPEHPLRPRRHRLRRRAGQQQRHPRARRRVPAGPLGKKVPARLRGRHGQDGQHRRRHRGGRRRGQGRLLRVQCQLIRRVVRRRLDWIGLVFKFGRERYYFCVDSFWFLQCIRIEI
The following text describes a protein:
Function:
Required for proper contractility of visceral smooth muscle cells. Mediates nucleation of actin filaments.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere.
Sequence:
MSRVAKFRRQVSEDPDIDNLLSTLSPEEMEQLQKELDAGDPDAGVSAGLRRDQTERASCQLEAERERENKKLAQRQATTEKEKSTGKVKEKKVEEDSKESRTKDQNKTKLEEPKDTKTQKTDLKKETPRPKDDRVSKMRERFRQDKNSSTLDKEKPEKKLSKKPSQEKVTKTTEKENTELKVEKEVKDIKREAEEKPPEKCQVPEKSPKKTEKVEGLSNDNKVTGKKLPNEEKKSLQQEQLDKKPENGTQNQTEENKEDESSSIFEELMEKVKNNDPETTELNLNNSDCITIETIMGFTEALEFNTVVKVFSLANTRADDHIALAIAAMLKSNKLITSINLDSNHITGKGILAIFRALQHNDTLTELRFHNQRHICGGKTEMEIAKILKENTTLLKLGYHFELAGPRMTVTNLLSRNMDKQRQRRQAERAAQAAENKKTNCLEVPKINTIQKTSPKPSPQPSPMNSLKRTSKKNEVPAPPPPPPPLAPLAPPLENIRNSLSPASQRRVVEKTGPSEKNSRDQLLESIRSSNVKQLKKVEVPKWLK
The following text describes a protein:
Function:
Required for the export of polyadenylated mRNAs from the nucleus. Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage.
Sequence:
MAEREALKREIEELQNLINDYKSTHGDVPSSAGQWGHPRRGLRSGQGQGRGHAAHYTQSYSSLPHMAHSSGSWRKTYSLNNKTNRASGSHVFHSAVSHPSLHISTSGATATGSNDGLIGSNSVSFKKQQPKQTKEKPVPSSHGVQCDTSKEKKSEESTKTTMLLSATEKVHHGCSSTNETTDSTSSSGSERKIKPTLKSSAVNNPSIPSTVKAAAQLQVKPHLPPSSSSNRTVVIPSAKKDSTTASSASNLQSQATVSPAKPQVKLDSTQTHAASPCHKRSQFTWVKSQETVNINSTPKPLTSGSSPGMIFTRRASSSSKRVSRKPNNSPGAPKTSKYTWVSSSCSLSTAGKANPSVKLPRKPLSPKSLKAPVRTFQGGMEGIKKEKKYTTVTVTPLKKSRAGAVTTSHASHTSRYRWKAAGQNANASTSSSASRTTHKSTVYRWTANNNGQKGEKGSTLSPNIPATAALSVGAFKLRSRTKIIRRSPSNPCLERRHSPNVQTLKSRYSLWRRTHTQVKSPTSIKRAQPKVLVSFGRHKLRRLSLTSTSLGTSRSGPSSSSVRSPASHRVIKTRYKIDTRRAHAIHHNPALSYRVKRVHSARALLQNRMRTTSERQWRGRSMRWIGGELYRVSANKLSRTQTTCTPTSRPGEWYNPYVSSSGHQGRTSATQYVASRAVQRSLAIIRHAKQKKQKAKQYCMYYNRFGKCNHGNTCPYIHDPDKVAVCTRFLRGTCKKTDGTCPFSHKVAKEKMPVCSYFLKGICNNSSCPYSHVYVSRKAEVCEDFVRGYCPQGDKCKKKHTLVCPDFSSTGVCPRGSKCKLHHRQSKKRTGSNASYGAAKKACTRDVLRSSDAAQTQSSESTLADEGSSCSRPEKLPSFISLSSSPDGSENPDTPKIPPATGPQAKGKTLHIKPRFLSTTQTDPSPKEG
The following text describes a protein:
Function:
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MKRRRLAQHFLRDPSVAEYIAGLVPSGLDVIEVGPGAGALTIPLAKRSKTVYAIEIDKALAERLRGIAPPNVVIIVGDALEVEWPRADFFVSNVPYSITSPLLFKLIRHRLPAVLTIQREVAERLVARPGSEDYGRLTVAVQCFYDVEILRVLPPYVFDPPPKVYSAVVRLMPKAPCVDNFDEFEKFSAWLFSARRKTLRRLKLADSTKRVYQLTLEELVELFKRHKA
The following text describes a protein:
Function:
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.
Sequence:
MVAACVGDFVRPKPGSPPTCHLYVANLGPAVGVSVLKARTIFAAFGTITDLQEAGESGNRLYVSFADSASAQEARAALHERPCLAAGGRVLSIQYAELKTAGLQTGPPLPEVCVSGEQVGIPGLVCIPDFVSEEEERELVAAVDDGNWHRLAKRRVQHYGYEFKYQSRNVDPTAELGAFPPPLQSVSQRVERLLTGECEQVCSEDDATGGKQTEAEQSWPLDQLTVNEYPAGVGLSPHVDTHSAFHGAIVSLSLAGPTVMEFRRQCQEAQAPDGSSSTDTTDGLLERRCLFLAPRSLLVLTGEARYAWQHYIPHRKSDLVRGEIVLRGRRRVSLTFRKVRTGPCRCEYPESCDSQQGVREGGPKRAEKGGWMRMEGARESGVQETGEAGMDLATATDKTLEALEALDVRTNLSPQAVEIRDGSTNTSRSECLPRLTPEEGSVHPLLSEESSGAGGASPFVVPEIEKRHVHQVYDAIAMHFSATRFAKWPKVAQFLEGLPEGSLVVDAGCGNGKYLGFNPSCFFLGCDISAPLVGMASKRGFDVAVADALRLPYRTASCDAAISIAVLHHLSSDARRRQAIRELLRIVKSGDRILITVWAREQEDPKLLGKWTPLIGTEAWPEDLVAPGGKQPGDRGSAQEQASGVEGLAGERTSEEGRGSGRKKMGLADRGGNEVGTTGEGTENGHGPSDASESPLRERRPSGTLESIPESGAGAPKPDRAANEVKVSMREGEVLLDPAENPDSPPSGSSAQADTSIELSEASEGSPLPGDGSGSVQEYFVPWHLPYHRVEIGVADRDGERGLARRDPLKQALVYERYYHVFVEGELERLVNEVGGCTIVDHFFDKSNWCVIAAKH
The following text describes a protein:
Function:
Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation and protection from uptake of C.albicans by human macrophages. Also mediates human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Binds zinc from its environment and then reassociates with ZRT1 to acquire this essential metal.
Subcellular Localization:
Secreted. Note=Found primarily on the cell surface of filamentous forms and enriched at hyphal tips.
Sequence:
MNYLLFCLFFAFSVAAPVTVTRFVDASPTGYDWRADWVKGFPIDSSCNATQYNQLSTGLQEAQLLAEHARDHTLRFGSKSPFFRKYFGNETASAEVVGHFDNVVGADKSSILFLCDDLDDKCKNDGWAGYWRGSNHSDQTIICDLSFVTRRYLTQLCSSGYTVSKSKTNIFWAGDLLHRFWHLKSIGQLVIEHYADTYEEVLELAQENSTYAVRNSNSLIYYALDVYAYDVTIPGEGCNGDGTSYKKSDFSSFEDSDSGSDSGASSTASSSHQHTDSNPSATTDANSHCHTHADGEVHC
The following text describes a protein:
Function:
Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MTSLLKLDKVSKVYGEGNTEVTALHPMSLDVKAGEFIGIVGPSGSGKSTLLSIAGALLSPSKGDIYIREQNITQLSEKEMTDIRLKKIGFIFQFANLVPYLNVKEQLLYIAKLKKESKQESEKRADHLLAAFGLGERKNHYPNQLSGGEKQRVAIARAFMNNPDLILADEPTASLDSKRAREVVEMMKREVKESQKAAIMITHDERMLDVCDRILTLRDGQLI
The following text describes a protein:
Function:
Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.
Subcellular Localization:
Cytoplasmic vesicle. Golgi apparatus.
Sequence:
MLTRNNPFLKGYDDGAEVDDWEDANFFLYKVTDRYGFLHKNPLPEGHDEKLIALERSRISKWLKMIKNWDKYVRSEKLRKRVYKGIPNSMRGEIWKKLLGVDKIPNRTTTYETMKRIARLQSPDLRQIDLDVNRTYRDHIMFRERYGIKQQALFHVLAAYSMYNVEVGYCQGMSGIAALLLMYLNEEDAFWALSVLLTDRKHGMHGFFIPGFPKLLRFQEHHDKILKKLLSKLFKHLEREGCHTSLYTLKWFMQCFLDRLPFSLTLRMYDIFLLEGDRLLTAMAYNIIKMHKKIFLKMNLEEVVQFLQENMHAYPYDDDEVVELLQSSMFELKRLGLDTPSPPKKDELPQLPPGAAL
The following text describes a protein:
Function:
Probable transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3'.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MESSSMTTHQEEPLDLSTGNHGNSELSDEQQIMQVMESCGMFLQQNLFAWFLQSMLEASASQPQLTQDEPPENDTKENDLVKQNKSEVNDENESTPSPTQNSRRRTSTGKIDRRMVGKMCTRRYEANARERNRVQQLSKMFDQLRVCLPIEDDAKISKLATLKVASSYIGYLGAILQENSNDEEEFKKQLQVELECAKTLRK
The following text describes a protein:
Function:
Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MRLLPLVAAATAAFLVVACSSPTPPRGVTVVNNFDAKRYLGTWYEIARFDHRFERGLEKVTATYSLRDDGGLNVINKGYNPDRGMWQQSEGKAYFTGAPTRAALKVSFFGPFYGGYNVIALDREYRHALVCGPDRDYLWILSRTPTISDEVKQEMLAVATREGFDVSKFIWVQQPGS
The following text describes a protein:
Function:
Lignin degradation and detoxification of lignin-derived products.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MAARTCLLGVLAFGFLCFICLPAEAALKKYQFDVKVSNVSRLCHAKQMVTVNGGFPGPTIYAREGDRVQINVTNYAQYNLHGLKQYRNGWADGPAYITQCPIQTGNSYVYDFNVTGQRGTLWWHAHILWLRATVYGAIVIMPQGGTPFPFPQPDREEVLVLGEWWNADVEQVEKQGNALGLPPNMSDAHTINGKPGPLFPCSEKHTFAMEVEKGKTYLLRIINAALNDELFFALANHTFTVVEIDAVYTKPFTTDAILIAPGQTTNVLVRANRVPGRYFMAARAFMDAPISVDNKTATAIFQYKGIPETVIPKLPTLPAQNDSDFALSYNSKLKSLNTPKYPANVPLNVDRHLLLTVGLGINPCPTCLNGTRLTASLNNISFIMPQTALLQSHYFNIKGVYTPDFPDKPPTPFNFTGAPLTANLRTNVGTRISKIAFNSTVEIVIQDTNLLSVESHPFHLHGYNFFVVGTGIGNFDLKKDPAKYNLIDPIERNTVGVPTGGWTAIRFRADNPGVWFFHCHLELHTGWGLKTAFLVENGAGSDYSEIVKCEQIVQCKTNVNGGFPGPTIYAREGDRVQINVTNYVQYNLHGLKQYRNGWADGPAYITQCPIQTGNSYVYDFNVTGQRGTLWWHAHILWLRATVYGAIVIMPQKGTPFPFPQPDREEVLVLGEWWNADVEAVEKQGNALGIPPNMSDAHTINGKPGPLFPCSEKHTFAMEVEKGKTYLLRIVNAALNDELFFALANHTFTVVEIDAVYTKPFTTDAILIAPGQTTNVLVRANRVPGRYFMAARAFMDAPISVDNKTATAIFQYKGIPETVIPKLPTLPAQNDSDFALSYNFKLKSLNTPKYPANVPLNVDRHLLFTVGLGINPCPTCLNGTRLTASLNNISFIMPQTALLQSHYFNIKGVYTPDFPDKPPTPFNFTGAPLTANLRTNVGTRISKIAFNSTVEIVIQDTNLLSVESHPFHLHGYNFFVVGTGVGNFDPKKDPAKYNLIDPIERNTVGVPTGGWTAIRFRADNPGVWFFHCHLELHTGWGLKTAFLVEDGPGSDHNVLPPPKDLPTC
The following text describes a protein:
Function:
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MHTFLYRTNSLLTFVASVLVVLCILASITDYFHRDSAVVAVDIVQVDRFQVSQAGNDEAFLAFNISADLRSVFTWNTKQLFVFLAVEYATPENAVNQVSVWDRIIERREDALIALPRVQNKYRLVDQGRNMRGRDLNLTMYWNAMPKSGRIYTGQKTLTGYRLPDTYS
The following text describes a protein:
Function:
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.
Sequence:
MRLLGCLVPALPEEKGSRQGHWERGWPGLVPKLRTRLSGSLAPPSAPPRRELRPKRRSWSWSCCCFCLVRIGRPPAPRLWAPLPFPSAGRCRQVRFLGAGFPSAMLMLLAFGLLLQENVAKIKDENLTDGSSLPQVQFYSYGKINLPEEHIPYFFHNNQQLAAACKRDHNCPYKKYLKKSRACWGYEKSCKPENRFGYPVCDYAEAGWASTIEEAQRVFWNQADFGYVKERMDEVKTYCKPKAVGDSSLQCSRYLQYCRATNLYIDLRSPKRTHERFNEDFFKKGQIGGHCDMDTTNFLAEGQRKSPLQSWFAELQTYTELNSRPMEDGSCDVVVDKLTYFMKFDAGVNMYHHFCDFANLYITQHMINSFSTDVNIVMWDTSAYGYGDLFSETWKAFTDYEIVHLKSYDSKRVCFKEAVFTLLPRMRYGLFYNTPLISGCHGTGLFRAFSQHVLHRLNVTQEGPKDGKIRVTILARSTEYRKILNQNELANALKTLSLFEVQIVNYKYKELDFKEQLKITQNSDIFIGMHGAGLTHLLFLPDWAVIFELYNCEDERCYLDLARLRGVHYITWEKKDKVFPQDEVVHWMEITHPVFVLCKMFYPSQFFHMKYDSAATVQIKFSALIKKSFYIKSWGRKRSKINWLLVQIVNNIAVRCFPTDVVALGSIDESVIMNENNYSSCHLFSSK
The following text describes a protein:
Function:
High-affinity uptake of maltose and maltotriose. Also transports alpha-methylglucoside, glucose and turanose but not melezitose or trehalose.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKNLSFLINRRKENTSDSNVYPGKAKSHEPSWIEMDDQTKKDGLDIVHVEFSPDTRAPSDSNKVITEIFDATEDAKEADESERGMPLATALNTYPKAAAWSLLVSTTLIMEGYDTAILGAFYALPIFQRKFGSQNDKTGEWEISASWQIGLTLCYMAGEIVGLQLTGPSVDLVGNRYTLIIALFFLAAFTFILYFCNSLGMIAVGQALCGMPWGCFQCLTVSYASEICPLALRYYLTTYSNLCWLFGQLFAAGIMKNSQKKYADSELGYKLPFALQWILPVPLALGIFFAPESPWWLVKKGRFDEARRSLRRTLSGKGPEKEILVTLEVDKIKVTIDKEKRLTSKEGSYSDCFEDKINRRRTRITCLCWAGQATCGSILIGYSTYFYEKAGVSTEMSFTFSIIQYCLGICATFLSWWASKYFGRYDLYAFGLAFQTIVFFIIGGLGCSSTHGSKMGSGSLLMAVAFFYNLGIAPVVFCLVSEMPSSRLRTKTIILARNTYNVVSIICSVLILYQLNSKKWNWGAKSGFFWGVLCFCTLIWAVVDLPETAGKTFVEINELFKLGVSARKFKSTKVDPFVVKTPLKTSLITTPREISKLPLQRNSNVSHHL
The following text describes a protein:
Function:
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTEPIRLLIAASGTGGHLFPALALAQQLPDYEIIWLGVPDRLETTLVPRQYPLQTIPVEGFQGRPSLKTIKIGWNLLRSVFTVRKLIKSKKINAVATTGGYIAAPAIVAAKLCNIPVIFHESNFIPGKVTTWLGRWCDTVAIGFRGTAKYLPNCATVWISTPVREQFRQPQSLDLPIPPNRSLIVVAGGSQGAVTVNQQVRSCVPAWVNAGAFIVHLTGKNDPEAATFSHDHYLSLEFFDNMAALLQKADLAISRAGAGTLTELAVTQTPSILIPYPFAAENHQMYNAQVFVDAGAALMFAQKSLTAEQLEQAGLDLLQSPENLATMAKAAGTLADLDSAEQLAAIVRASVEKSR
The following text describes a protein:
Function:
Plays a central role as a glucosyl donor in cellular metabolic pathways.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLHRRIHFKSQSTLDFDSVAVSISASTMKNELDKLVLNSRVSDKKTFGIQMDNFFALYRRYLLHTVKGYECDWDSIRPLGPEDMIDYGDLPLCKNAGKYLNRLAVVKLNGGMGNALGVNYPKAMIEVRDNQSFLDLSIRQIEYLNRRYDVSVPFILMNSYDTNDETCKVLRKYAGCKIDISTFEQSRYPRVFVDSQLPVPKAAPSPIEEWYPPGHGDIFDALVHSGTIERLLAQGKDYLFVSNIDNLGASVDLNILSHVIDNQIEYSMEITDKTKADIKVGILVNQDGLLRLLETNQVPEQHREEFMSDKVFKYINTNNVWLYLPAVKRVVENRELNLDIMPNIETVYYNNEPARIIEFTTAIGSAISQFKKTEGIRVSRPRFISVKNSSDLFLVRCDLYNVDHGSLKIEESRLGFPPPVVRMSNEFKDIAELFCRIPYMPSMKDLVSLSISGNVYFGRNVILKGNIVIVASENTILCIPSNAVLENCVVTGNCKIMEC
The following text describes a protein:
Function:
Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity).
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MVFTSMNTQVRVPQPPPVPAAVVNPTVVTPAGPHPEEIDEAFASSHELRKRTSLFRDISTFILGQASQPSAEPAAKKRKLEEKTTSQSAPAAPGGSLVSSATKAWRTYPGVSFSIPQRKKFTLELLDKKDGGIRAIGASGNVEFSIAWKDVDQVFCLPIPEKAKKQHNFVVIPVHGDGINPLPEHLQGAAPEPIIWTFEEATGKNIVEGEDPGPGPMAEAIHHCLIQAGTGKQVIFPDAEEFASATPESHRKGDKAYHVKAHRGSKEGYLFFTSVGILYGYKKPLAYFDFASVNSIAYAAVLRNTFNLVITTQTQEIEFGMLDQADYAGINDYVQKHGLQDASLAAARRAKKLNVNKPKDKSNGTAPPDADDAEEEEGELQKAERELQDQEDEEEEDYDPGSEGESEGSGSDSEDEDGGGGYDEGDGDEVEADDDEMEE
The following text describes a protein:
Function:
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
Sequence:
MAGLEILVGTYEEFIVCYRAEPLRTDPEKLYLKESFAAHLHTSSVRSVASHGRYVATGGADDRICLLDMREGTKVTEFLHHDGTINALVFSDDGSHLFSGSNDGSMTAINMSKLAVDKTWKSAHKTAVQSISIHPHGKMALSLGSDMTLKTWDLITGRALFTTALNKNSKYGRVLADVQWSPDGEHFALLGNRVVDIISIETTRSVRLLEYDSKPTAMCWLSAEEIAVGLENGALVMANIHEEEQQEKLQIYDSRLKAISCLGNYIATASSAGDVSLWHLDGVDFIQICTQQIGCRPICLALINTGKPLRQDSVQESAESTLNTAASKNKAQMPARSIASKVVKEMAYVSVETEDPVQIASANRLKDRSLNKRKRAASKKDIKPSDRRVKSSGFIEEPADDVIEPSKADNLVEAKKKKKLKT