The following text describes a protein:
Function:
May act via the Piwi-interacting RNA (piRNA) metabolic process mediated by aub and AGO3 Piwi proteins, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. Not involved in repression of retroelements.
Miscellaneous:
MISCELLANEOUS: The TUD mRNA accumulates within the posterior region of the developing oocyte during the early to middle stages of oogenesis.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Note=Component of the perinuclear meiotic nuage (also known as germline granule or P granule), a germline-specific membraneless ribonucleoprotein biocondensate involved in post-transcriptional regulation of transposons and mRNAs. Localization to the nuage requires aub but not AGO3. During late stages of oogenesis seen in the pole plasm at the posterior end of the oocyte.
Sequence:
MNGQARIALPSKVDLYITHVDHVGPYLKVYGHVNRDAASLISERIRNLLPTCFAIEPSWSVERQQALLIPGTFCIFKNINGPAPGDVEYRRIRVVSADLEGQSMRAEIDFVDFGYKRTVDSHDLMFPKQPKLLQNIPLHCFQYIVLGICSEWDQTDLAEVRRLVVNQIVKITVEPTQICDQKFASLRWKDFELNEFLVQQKQIGVSVDKQLMMDHCKKLWKDNPQSPVTEYNNNSIHNSKTPMEIAREQLAVRQSLAARLDAQRSVQVTPSRPLNADAPDYTPKHLPLVNVTNVQVQMPGLNNTQKPVFVSTNPYNRANYQPAVPAAQPYVPKANPRSQYTYYNVRMNKPINAMPPPAGPHVPIQHFNQQANNVSLSYVPARFTPPPTPSIAQHQIPIPAFRTTSLTVGLTYDVVISYVENGPYLFWVHLKSSDHDLSTMMGQIERTKLKALAQAPELGTACVARFSEDGHLYRAMVCAVYAQRYRVVYVDYGNSELLSASDLFQIPPELLEIKPFAFRFALAGTKEIEPIDDSMKRIFKKSAIYRNFELTVQAPESVGSMQTCHLNQNGTNMLELLRQLKNSRQSYKKAEQLENDDAVEIRFIDSPSNFYVQKVANIGKFEQLMDEMFSYYNANQRVPDQLILGAPCIVKCDQEWYRAEILRVDDSVIVRHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCLKGFENSELSEDKITDQFEMLAEESNIRRRTFSVRIFRIEPDGLNVVNLLAKNLNVMKKLYKLSMPFEQYLSLEKGQFNANNTRAESVISSELNKSHILNSTSIGETENRLQEQEKEQQQKKVDVRQQQLAVEIPQAVKSVSGSKNSTDWDKRSSTSAGSKDSKRQQQQQIQRIDRHLDFSCETQSTGSYSSGMSSPRKGNRQQNGRTPIQSPRHNEKQEAKKNARFSNSESPRRSRDGQQGNQRSQNAPQGYAQKPQRQKSTLDGNISSKRSSGVGSDIASSSSESVAAAKPEKYVSLDKPYALQEMKTPSKEAASLSWWLSPFQFYIVPKSVSAKYDNIMRDMREFYRQKQHQPLQLKVGSTVVVRQRKDNAILRATVTACNHMMRKYRVFCVDTGSLITVTSEDIWQLEQRFADPPCMAHRCSFHSVVTNYDPLYIVDRMETFVPVNAKVDCEFVSKEKSNQGSNTSSTCSYTVNIFVNGASLRDMLVKAEFLTEVAPEIRVNLLAGQQIRGKFTSIRDMTSFKVQFDYGNNVNFLCTYDDAKFVKSNPNLARRFKEFYEGKSFALNVKNVCENNIVHLRPVMPLFMEDRRSFICPYPVVLSSFQALVVYTAKPYRVYVQPQAIVPSMQTLLDNMYEHYKAKGDSLKKFDVGQICAVRSSDGNWYRARISGKDSNAACFEVFYIDYGNTEEIKRDDIKALDAKFYEHASGFAVEINLPIGRPSNDTKLKARISEILEEKVVTIKSIEVRRSHLIADVILENNQSVIDLLKAEKLVPGKDLDYMRKQMEKGKSRTYEYIETVDLTLDEEEDKGRKETVSKSGSANASPKKKQHNDKDREPKKSKPAEPARTVAPQPVALKTPSPVPAEPAPVPKPATPVPEVVEVPEINPTVREAAAESKQAPAQEDPYKDLDCVVLSHCDNPAQFYVHPIDQLSKLNQLHENLQIVSPSLPQLMNVVNGADCVSMYSVDKCWYRAKIIDAELMVLLFIDYGNTDCVSDATDIKESMWSHIEPFCLPCALPIRPKGTADWVDAANGIFNESYSKVPRLEYLTQGDHYTTSYVNMYIDGEDVAKKLIADGFARPLEYLASGCSCYISHVNGICDFFIQLERDSKALELIELYLRKKDTLKPLEGFEKGLIVAALFEDDELWYRAQLQKELPDSRYEVLFIDYGNTSTTSKCLMLSEEIASLPSLSKKCSLQLPDAYISWSPEAEAKFAELTGEGELVFTTQLLKPGQDHVTIDLLLDGENIIDRLLPLCQRKEPKEASKESLAVTTKAIITHVENTSRIYLQFSEKDSLMDIICEKLNGSKLQPKTEKAAVDDMCVVQFADDLEFYRSRILEVLEDDQYKVILIDYGNTTVVDKLYELPQEFTLIKPVAEICSMEPSAIFEKNKALTLTTFDALLDSCKGVVAVEFVNKSASPPVVRLTTKDKRSLKIYEHLQKLVQAELKLIQKRNENSECIISYGNSPKSFYVQMKHNSADLDLIVKTLQSLKKEKLKKLIDPTTNSNGVCYSQEDACYYRCSIKSVLDPSQGFEVFLLDYGNTLVVPEVWQLPQEIEPIPSLALHCQLSKIPMDVSDEKLEEAFAALLEQHFGELYEITTQPNEDETKPLIAELRINYKDFVQELVSTVTGVQKPLEAELHNCVVVQFDGPMSFYVQMESDVPALEQMTDKLLDAEQDLPAFSDLKEGALCVAQFPEDEVFYRAQIRKVLDDGKCEVHFIDFGNNAVTQQFRQLPEELAKPARYSRHCELDASTISKCDAALLQSFIDTRFSETFQVEILATKGTGTHVVRLFYQSKNISEKLQECQ