lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of a CST-like subcomplex of the holoenzyme telomerase ribonucleoprotein complex, which stimulates telomerase complementary-strand synthesis (Probable). Telomerase is an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (Probable). The CST-like subcomplex (also named 7-4-1) binds telomeric single-stranded DNA and coordinates telomere G-strand and C-strand synthesis (Probable).
Subcellular Localization:
Chromosome, telomere.
Sequence:
MEIEEDLNLKILEDVKKLYLQSFDYIKNGISSSLPSDKKFLADDDIDLSRITFLYKFISVNPTLLLINEKTQAKRRIFQGEYLYGKKKIQFNIIAKNLEIERELIQFFKKPYQCYIMHNVQVFQMLNKNKNNNVVEFMDSEDLQSSVDCQLYYLIDESSHVLEDDSMDFISTLTRLSDSFNSNEFVFETNYSIQISQMPKPLNTTHFKLLQPKVVNSFEGVILQVQEGKNILQIEELIDQVYLNSRRDRFYILKVANGKNYMDFIEVYLVYDNEDQEAKQQLQFYLKPFQRILIFQSLKHFTKNLKLFMISFFYSSGVQPNNSNVKNFLVSHKGVEFFSRFDIQKNELLCKDLIKSYNKLPLSNISKLLEDEGVMIRSNMKFQVRVKKVKYFKIRLNCLNCKQEWTVGLKNCINCKGQQSYISYNIQVLVQDQHFLEQQAYIYLYDDLAAQFFNITESEKKELHLHLTKNETFIQLYYSFNKDYPLSIIKFKDKIFNKDITNCIVAYPFADIDNKIFNSQQQIIQDENLRIESEKFIQNFTEDNNLQESKLYYEKFKSKNKQQIFVNGTYISTNYSQGQKICLKPIPCLKVMYVFPQEDIKLSALKIIEEINQLKIQIDQLN
The following text describes a protein:
Function:
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
Subcellular Localization:
Nucleus. Nucleus, PML body. Note=Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner.
Sequence:
MWNNHGGFDGGYGGSGMGGGGGYMQSPGGFGSPAPTQGEKKSRSRSQQIVPCTVSQLLSATQNDEVFRIGEAELSQVTIVGIVRHAEKAPTNILYKVDDMTAAPMDVRQWVDTDEASCENMVVPPGSYVKVAGHLRSFQNKKSVVAFKIAPVEDMNEFVSHMLEVVHAHMAMNSQGAPSGGGSTVALSTPGRVGDSGRAFSGGNDNPTNGLTPHQSQILSLIKSCKGNEGMAFEELKNRLHGMNVNTIRQAVEFLSNEGHIYSTIDDEHYKCTDGD
The following text describes a protein:
Function:
Acts as an E3 ubiquitin-protein ligase.
Sequence:
MNEYGCNVCNEEYSARDPLKCPRVLTGCGHTICHNCAISIAGRNSSIFCPFDRTATQIPGGDLQNLKKNFALLELLEKIADGGGLLEKSGEVVKFDRYSKERLLNLECDEDSEHVAVIYCTVCDSNLCERCSESTHSTNVLSKHRRIPLTEKPPPLVHCRLHSSYVVEFVCKELSCDTESPLMCMMCRDYGRHKGHSHVLIEKEVEDLREKVREHLGELSKQSETIGNALHSIDSVIHELTPGQEDGSLEETRQEVRNHFRRLRTALDRDEEDAVETVDRYARNRVESLQTQKERLEAISSKIGNTCTTLQKALIMERGKILDRKDDLLALAESTAAEPTAVLDQSQLSTRIAFSFLNDRKLHIGDFIESRVVLLGLDGAGKTSIVRRLKKVQMDTVMAPHPTIGFNIETIHYKNYRLNFWDVGGLPKLRHLWKHYYSNAQAIFYVIDGYAVERFSEAIKELNRVMSDPLVGTCPVIVAVNRKDGYALNGHMDALLSQLEALPFQHHFHCCDAATGSGIDQIIDQITVCLSRLNGTCPV
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MIIQSLERTAHLAWNPVGEDILLATGTDAQQLSPDFSTTGHLEVVRPQLSSSSAQPDQGSTNPDVVVSLESPDRFHDLKWAAPASRENGLLVGAMDSGVIRLWDADALMRNDPNALLAAPRHHSGAVRGLALNRLEPHLLASIAADSEVYIMDLNKPEQHFAPGPDLQPPQAMTGVAWNCQVPYILATAGASGRTTIWDLRASKAIMTLSHNTPGFQPRSLAWNPDQGLSLIVASDSDATPVIQLWDLHNAQACVHQLQGHQKGVLSVAWCPQDSNLLLSGGKDNRALLWDPLAEAYEDQLLKELHPAGNWIFDVNWCPRNPSLVATAAFDGQVRLQSVEAGSEVATTNPQPVLSPRLGAHTPTSVGGQSTGQPGGSGHHHHHTPKWLKRPCGACFGFGGHLVRFSSESRRVQVFASVRDDQLATQADSLNKALAATDTQTLEQRTEALEQTGAAGAIDGDDVIWRCIVSSLDPQARNKYMGLLELSADTVAQEADHIASGVSQGPAVPPTLGDDLYDGCFNATPGTSEHVLVQALAMRQFDLAIDVCLAEDRMADALMLAIAAGPTELSRVQQFYFARTQSPSARLLRMITEERWLDIVSHMELAAWQDCMALLLTYAPANVMGDLSNALARRLQNQGDWFSACLCYVIAGALDDFGSCYGALLQDSDLTDAQQVYACVEKLTVLRRALALQRGQSPPVSPAYTQRVLALCSTLADQHDLKAAYGILSAAIESTDPWPRTAAPTLRTQLAVAAGAKPLPTSINPNAVASAQLRANLAQSSPGYGANAGPSGFFTGQPAPTHMSNPAARSPYPSSAMNAFSPANMGVPNGHGAMSAVSAAYGTSHAPATMPGGYGASGATPYQPPAASAPHSSAPPLAAPAPTYPASSSYNPSMGYGAPPPSRLSASASMRPAAGMTPPMGLPTQATASVAPITTPGMYAGGHMGANVAGGAVHAAATPAAAPVAAVAPKAKPDKRWNDPPMIMSRKKQQFQAPAPIAMPIVGAPEQAQSQPAASAMAAAGGATAHAAMGGAASPAAAAAEAAPAPAPEPEVPAEFQPLVEKFEALVDQYDARANAAQKRKLADVRRRLLSLKQVAANQYLDSETGQSMFYSLQYIELGDFANALAYQQYLTANTNPDVTGQPLMALKALINIAKTQSS
The following text describes a protein:
Function:
Serine proteases that hydrolyze many proteins in addition to elastin.
Subcellular Localization:
Secreted.
Sequence:
GGGFEQEGWEAIPKPRSAVYPRAGWDTACESSKNLTVLEPILGKVRATLHAGLSGWQILSHEQTKASSRGLSFPTTLIDRKTSSAGHSTQDVPETNARVVGGNDARKNSWPSQISLQYKSGSSWYHTCGGTLIKQKWVVTAAHCVDSQLTFRVVVGEHNLNQNDGTEQYVNVQKIVVHSQWNRNNVAAGYDIALLLLAQSVTLNSYVQLGVLPQSGTILPNNTPCYITGWGRTKTNGQLAQTLQEAYLPSVDYSTCSSSSYWGSTVKNTMVCAGGDGIRSGCQGDSGGPLHCLLNGKYAVHGVTSFVSSLGCNVSKKPTVFTRISAYISWINNVIASN
The following text describes a protein:
Function:
Peptidyl-tRNA hydrolase which releases tRNAs from the ribosome during protein synthesis. Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.
Sequence:
TNLNIAGLLVSVVCGVACGWFLRGFKDTSKTSSDEEEWESDDNGDEDAGGSYKMVIVVRQDLKMGKGKIAAQCSHAAVGAYKQLNKHKKSTLKSWEYCGQPKVVLKCQDETELLALHQHAASIGLTATVIQDAGRTQIAPGSRTVLGVGPGIESLVDKVTGHLKLM
The following text describes a protein:
Function:
Pore-forming (alpha) subunit of a voltage-gated inwardly rectifying potassium channel. Charactherized by a fast rate of activation during depolarization followed by a rapid inactivation at much more depolarized value causing inward rectification due to a C-type inactivation mechanism. Exhibits a rapid recovery from inactivation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVANVYPIVYCSDGFCELTGFARAEVMQKGCACKFLYGNETSEIQISQIESALEEKDEFKTEVMFYKKNGTPFWCLLDIVPIKNEKGEVVLFLASHKDITRTKLSSMDLDEAEANEQGPTPRFKGAYVNASYGRRTGQQFQRRRSRAVLYQLSGHLQKPTQGRSRLKKLNSIEAERNQARAQYTNGFISDKMAVPEYKTESIKKPHFVLLHFSMFKSGWDFIILLATFYVAVVVPYNVAFALPCEKGRGPNFTKPSFVSDVIVEMLFIVDIILNFRTTYVTSSGQVVYDARSIALNYAKTWFFVDLMAAVPFDLLYAVNVEINILGESPRPTRPNEVDQTSFVHLMKTVRLLRLARLMQKLDRWSQYSALVLTLLMSFFGLLAHWLACIWYVIGREELKTHRWELGWLFELSRRIDQPYALGAGCGTLANRSIFNSTSNFTEGTDLLRPSEGGPDITSAYLTALYFTLSSLTSVGFGNVSANTNAEKIFSVCTMMIGALMHAAVFGNVTAIIQRLYSRRSEYHTKTKDLKEFTKLHNIPKALKTRMLEYFQAHWSENHGIDKVDMMKDFPDELRADIAMHMHKEILSLPLFENASQGCLRSLSLHIKTTFCAPGEYLVRHGDAMTTMYFVCSGSLEILRNGMVLAILGKGDLFGADLDAVDNVSKSNGDVKALTYCDLQFIQLPKLKDVFKLYPEFFQKLTRDVRHDLTFNLRDGCDTGEERSRSYTRKHDQDAADHVPKLPSISEDDELEDDDDATSSPQSPEEKPGVPKPPRLNLPRNSLPESSTTNLSPRSIDGSEETFDRWSGSRAFEFPSRRRSTGMTGLEARRTIRFVDGGEDENSLWKSRSFEFPSRKRSPVSGRRHRYSFGCCETAYGRPPSALQPPSSGAGAGDMDYLTVPYTPAGETRRSSVPWEMTLDDIGESRHSSTSNLDASELRGEVEYTRNTVDRLDKQVSSLTRDVATMSADLRQLMQLMQAHVAATSGAAVSTTSSPTHPKAAVERHHSQSPSLAQSGRGSSLDTNSSSSSRVTVIPMSNSREPLLEKQDCVFESEESLPSRGSRSSSVSSASSARKLSPPDCTTDRTTAHKKPM
The following text describes a protein:
Function:
Plays an important role in assembly of the mitochondrial large ribosomal subunit. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. May play a role in mitochondrial apoptosis.
Subcellular Localization:
Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids.
Sequence:
MNNRAHTFLWGIRQFRTSIPRSRALRTYSLVFCKPEVIHSKRNPRNHLLNGFDEGLQPSVRYLFQDIFISKSVAGCTQTRGIIHAAGFKLDRILCPRRLSFDAKHSFVSDGTSDHDLMKTNFHHTSTEDVLTKKMRPTPVNYKKLAQECNSLSDVLDTFSKAPTFPGSNYFLAMWIIAKRISEDKRRFEKQLMFSHPAFNQLCEQMMREAKIMRYDHLLFSLNAIVKLGVPQNSLMVQTLLRTIQERISECDERCLSILSTALVTMEPCMNVNALRAGLRILVDQQVWNINDIFTLQTVMRCIGKDMKALKELGRFSVLNSRHMFEVLAAMDHRSVVLLNECSKIVIDNIHGCPFKVLISILQSCRDLRYQNEDLFKSIADYVATTFDIWKLKHVIFFLLSFETLGFRPPGLMDKLLEKVVQEPGSLTVKNIVSVLHVYSSLNHVHNVQNREFLEALASALTGCLHQISSESLLNAVHSFCMMNYFPLAPINQLIKENIIHELLTSGDTEKNIHKLHVLNTCLKLDESTYKCIHIPLPQLPLTASHPNEKLAEVLSRLLEGDGCFSRNVQLPHNYHIDFEIRMDTNRTQVFSFSEGDASSATNMQRVAVLCVPKSAYCLNSNHLRGLMAMKIRHLNVMGFHVILIHNWELKKLKMEDAVTFVRKKIYSDEALATTDESV
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MPVFTKEALERLPIQLGNFFKKFPPENPNAWTTNPNRQNPFLATRNPQNGLVINPYYSNRRQAEIYKEARLQNLDNLLPQQMSWQKDSTRHILKGLLNPKGKISERKRDEILENRRLKLSESLKKTSKFKNERQKASKIAKPSPF
The following text describes a protein:
Function:
Transcriptional repressor probably involved in abiotic stress responses. Binds DNA in a sequence-specific manner and can repress the transactivation activity of other transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MALEALNSPRLVEDPLRFNGVEQWTKCKKRSKRSRSDLHHNHRLTEEEYLAFCLMLLARDGGDLDSVTVAEKPSYKCGVCYKTFSSYQALGGHKASHRSLYGGGENDKSTPSTAVKSHVCSVCGKSFATGQALGGHKRCHYDGGVSNSEGVGSTSHVSSSSHRGFDLNIIPVQGFSPDDEVMSPMATKKPRLK
The following text describes a protein:
Function:
Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm.
Subcellular Localization:
Dynein axonemal particle.
Sequence:
MSALGESNNKQNGKEILHNYVTKKLTSQPYSCQWIPTSCSVVTVGKKTSGGISKGDIKIHQLEFDDTSGDPKLNLVYENEFTNPFRCLSFFKQANQLQQQDNRKFITGDFNGQISEWDSDICDIPIWGVKGAHQGSISAIDAYADNLVVCGGKDGTIKVYDTRIKPNSANDNNGNNSSPISTFEQTNKSNCWSICTNDNNIIAGFENGDLNIYNLKTNSIQSTTKLNGGICSIDSNDRSNILNQFLITTNKSFISIASFNNNNNNNIEFKDYDINKEPNQTIWSGIYSPWNKKDNENIFTIAQGDGSVSMYRDDCKLIDKVLVSDLPILSLDYSKDRKGLLCCISLKKQLSILISPC
The following text describes a protein:
Function:
Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. The C-terminal di-lysine motif is required for exit from the endoplasmic reticulum. Required directly for packaging glycosylated pro-alpha-factor into COPII vesicles. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
Sequence:
MSYRGPIGNFGGMPMSSSQGPYSGGAQFRSNQNQSTSGILKQWKHSFEKFASRIEGLTDNAVVYKLKPYIPSLSRFFIVATFYEDSFRILSQWSDQIFYLNKWKHYPYFFVVVFLVVVTVSMLIGASLLVLRKQTNYATGVLCACVISQALVYGLFTGSSFVLRNFSVIGGLLIAFSDSIVQNKTTFGMLPELNSKNDKAKGYLLFAGRILIVLMFIAFTFSKSWFTVVLTIIGTICFAIGYKTKFASIMLGLILTFYNITLNNYWFYNNTKRDFLKYEFYQNLSIIGGLLLVTNTGAGELSVDEKKKIY
The following text describes a protein:
Function:
Receptor for PDF, a neuropeptide controlling circadian behavioral rhythms. Probably regulates circadian behavioral rhythms through coordination of activities of clock neurons. PDF-binding results in the elevation of cAMP synthesis. Plays a role in sleep regulation and regulates the state transition from sleep to wake.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTLLSNILDCGGCISAQRFTRLLRQSGSSGPSPSAPTAGTFESKSMLEPTSSHSLATGRVPLLHDFDASTTESPGTYVLDGVARVAQLALEPTVMDALPDSDTEQVLGNLNSSAPWNLTLASAAATNFENCSALFVNYTLPQTGLYCNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDTRKFAIRKCELDGRWGSRPNATEVNPPGWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIENTPYLCEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAAIVLLPLLGITNLLHQLAPLKTATNFAVWSYGTHFLTSFQGFFIALIYCFLNGEVRAVLLKSLATQLSVRGHPEWAPKRASMYSGAYNTAPDTDAVQPAGDPSATGKRISPPNKRLNGRKPSSASIVMIHEPQQRQRLMPRLQNKAREKGKDRVEKTDAEAEPDPTISHIHSKEAGSARSRTRGSKWIMGICFRGQKVLRVPSASSVPPESVVFELSEQ
The following text describes a protein:
Function:
Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.
Subcellular Localization:
Cytoplasm. Nucleus. Note=May translocate to the nucleus of germ cells after heat shock.
Sequence:
LSAMLEDTENWLYEELSLTQDPVV
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MAPTAMGASSTGVGGVAVNGAGGSTSGDAPGSLEEATQRYQTTKLGLRTGLANKRLIDRSLVDLESQIYLFEGSYLQCTASSGGNIVKGFDGYLKNSSTSTATARTAHPTLLADIPLEDRIFSLSSATYQKSLEFKANESLTEQERDSDITPKSSKNSTTPADLASSTPTPVIKKSKKDKDTASTSAATNTPSVKKKKDKDATKENERSATPQIKNTPAAGKNADAANRASTPTKSIAPAGGKAATTSKLKRKLTDATTSAATASTTKPVKRKKDED
The following text describes a protein:
Function:
Major helicase player in mitochondrial RNA metabolism and maintenance. Likely component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Regulates mRNA stability and is required for the correct processing and maturation of mitochondrial transcripts.
Subcellular Localization:
Mitochondrion.
Sequence:
MLQNGRRLGALCTAVQNLSLNRNLLARHNLKLSQRRFKKNDSSISSLFIPVPVKPNPDDINVGAELTGNLNKADLLKVLNKFYQKKEIKQLLTENGLDNYLQHQAYVSFRRYCLEAQTLPVDLHVVVSDVLQGAGNITDIFPYFLRHAKQMFPHLECMDDLRKISDLRTPANWYPEARALNRKIIFHAGPTNSGKTFHALESFITAKSGVYCGPLKLLAAEVYKKSNSRGTPCDLVTGEERKYADSSGQPSTHVSCTVEMASLTAPYEVAVIDEIQMVRDHQRGWAWTRAFLGLVAEEIHLCGEAGAIDLISQLCLTTNEDIEVRHYKRLTDLKVEDTALGSLDNVMPGDCIVCFSKNDIYSVSRGIEATGKEVAVIYGGLPPGTKLAQAAKFNDPENSCKILVATDAIGMGLNLSIRRVIFYSLIKPTMNEKGEKEMDTISVSAALQIAGRAGRYGTQWEQGFVTTFKPEDLKTLKTLLESLPEPITQAGLHPTAEQIELYAYHLPNSTLSNLMDIFVSLSTVDDSLYFMCNVEDFKFLADMIQHVPLPLRARYVFCCAPISKKMPFVCTMFLKFTRQYSKNEPITFDWLCRNIGWPLQPPKTIIDLVHLEAVFDVLDLYLWLSYRFMDLFNEPDLVRDMQKELDVIIQQGVVQLTRLLRNSETGARGADEEQFALNRQKQSYLRESKALLGRGRLTERLLAQGILTPHMLHELKKEWKGGDEEGDGDDEPKKPTRRKRKK
The following text describes a protein:
Function:
Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MAQPHPWWLCVLGTLVGLSATPAPKSCPERHYWAQGKLCCQMCEPGTFLVKDCDQHRKAAQCDPCIPGVSFSPDHHTRPHCESCRHCNSGLLVRNCTITANAECACRNGWQCRDKECTECDPLPNPSLTARSSQALSPHPQPTHLPYVSEMLEARTAGHMQTLADFRQLPARTLSTHWPPQRSLCSSDFIRILVIFSGMFLVFTLAGALFLHQRRKYRSNKGESPVEPAEPCRYSCPREEEGSTIPIQEDYRKPEPACSP
The following text describes a protein:
Function:
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Does not reduce bilirubin IXbeta. Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7). NADPH, however, is the probable reactant in biological systems.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
LNPYPERKFGVVVVGVGRAGSVRIRDLRNPHPSSAFLNLIGFVSRRELGSVEGVPQISLEDALSSQEVEVAYICSENSSHEDYIRQFLNAGKHVLVEYPMTLSWAAARDLWDLAEQKGRVLHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAGPLEQERFGFPAFSGISRLTWLVSLFGELSLVSATLEQRKEDQYMKMTVCLETENKRPLTWIEEKAPGLKRNRHLSFHFKSGSLENMPNVGVNKNIFLKDQNIFVQKLLGQFSEKELAAEKKRILHCLWLAEEIQKHCYSKE
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Sequence:
MASQSAGIQQLLQAEKRAAERVAEARKRKNKRLKQAKEEAQAEIEQYRLQREKEFKAKEAAALGSHGSCSEEVEKETSEKMSIIQQNYAKNREKVLENLLSFVCDIKPEIHVNYRVNG
The following text describes a protein:
Function:
As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It is strictly dependent on the extracellular presence of sodium. It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate. Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEAHNVSAPFNFSLPPGFGHRATDTALSVILVVMLLLIMLSLGCTMEFSKIKAHFWKPKGVIIAIVAQYGIMPLSAFLLGKVFHLTSIEALAILICGCSPGGNLSNLFTLAMKGDMNLSIVMTTCSSFTALGMMPLLLYIYSKGIYDGDLKDKVPYKGIMLSLVMVLIPCAIGIFLKSKRPHYVPYVLKAGMIITFSLSVAVTVLSVINVGNSIMFVMTPHLLATSSLMPFTGFLMGYILSALFRLNPSCRRTISMETGFQNVQLCSTILNVTFPPEVIGPLFFFPLLYMIFQLAEGLLFIIIFRCYLKIKPQKDQTKITYKAAATEDATPAALEKGTHNGNNPPTQPGLSPNGLNSGQMAN
The following text describes a protein:
Function:
May play a role in the development or function of the peripheral nervous system by regulating the processing of nervous system-specific transcripts.
Subcellular Localization:
Nucleus.
Sequence:
MLGSHHQLLIAATAAAAAAAAAEPQLQLQHLLPAAPTTPAVISNPINSIGPINQISSSSHPSNNNQQAVFEKAITISSIAIKRRPTLPQTPASAPQVLSPSPKRQCAAAVSVLPVTVPVPVPVSVPLPVSVPVPVSVKGHPISHTHQIAHTHQISHSHPISHPHHHQLSFAHPTQFAAAVAAHHQQQQQQQAQQQQQAVQQQQQQAVQQQQVAYAVAASPQLQQQQQQQQHRLAQFNQAAAAALLNQHLQQQHQAQQQQHQAQQQSLAHYGGYQLHRYAPQQQQQHILLSSGSSSSKHNSNNNSNTSAGAASAAVPIATSVAAVPTTGGSLPDSPAHESHSHESNSATASAPTTPSPAGSVTSAAPTATATAAAAGSAAATAAATGTPATSAVSDSNNNLNSSSSSNSNSNAIMENQMALAPLGLSQSMDSVNTASNEEEVRTLFVSGLPMDAKPRELYLLFRAYEGYEGSLLKVTSKNGKTASPVGFVTFHTRAGAEAAKQDLQGVRFDPDMPQTIRLEFAKSNTKVSKPKPQPNTATTASHPALMHPLTGHLGGPFFPGGPELWHHPLAYSAAAAAELPGAAALQHATLVHPALHPQVPVRSYL
The following text describes a protein:
Function:
Involved in the biosynthesis of germacrene-derived sesquiterpene lactones. Hydroxylates 8-beta-hydroxy-germacrene A acid to 6-alpha,8-beta-hydroxy-germacrene A acid, which, in turn, undergo spontaneous lactonization to become eupatolide.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MDFLTYLPSWLLPAVVILTISCILMLWTKPSKGASGLNLPPGPPSLPLIGNLHQLIGKSFHETVYKLAEKYGPIMHIHMGSQPVVVISSSALATEAFKTHDHILANRQYSNNLRRLTFDYNDIAWAPYGDHSKHMRRVLVTEFLNSRMSKSFKKVLDMEVKSMLDNLPYGTETNLNKVFGNFVCDFTSKVVTGKSYRDVKIRGKTMKEMLDEMIILFSGSFSEIFPKYGWILEDLSGWTRRVDKHMANYNDLLELMIDEHLDHTSEDEKDMIDACRPLLNREEMKAIMSNVYNGAIDTSYLTLVWAMSEIVKNPRVMHKLQDEIRSNAGNKARLDETDTSKMTYLKYVVKETLRRHGPSPFLIPRDCVSHIQIGGYDILPGTKVLINAWGIAKDPKVWTENANEFHPDRFENHVLEQFHMVPFGGGRRACPGYNFATLNIEVVLANLLYSIDWKLPPGLTLEDFNMEEEGSLLVTKKTPLYLVPIKHNTQA
The following text describes a protein:
Function:
Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The UBA domain specifically recognizes and binds 'Lys-6'-linked polyubiquitin chains.
Sequence:
MAELTALESLIEMGFPKGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLATPLGHVLGREPTPSEQGGPKGPGSAVGEGKPVLTEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELTAARQRLQEDEMRRAAEERRREKAEELEARQRVREKIERDKAERAKKYGGNVGSQPSPPATEPGPVPSSPSREPPTKREYDQCRIQVRLPDGTSLTQTFRAREQLAAVRLYVELHRGEELGGAQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIVAKKCPG
The following text describes a protein:
Function:
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
Sequence:
MDNALLSDVTGVILVGGRSRRMGRDKALLSLGGAPLVARVIEAFRRVFARTVLVGDRGERFREFGVEVISDIHPGSALGGLHTGLARAGTPYVFVAACDVPWPDSRVIAHLCSLRSGYDVVVPRTDGGFEPLFAVYGTGCLPAVERMLRQGNCRIYDFYPEVRTRQVTMAELAGLAAPERTFVNVNTPSEFEHIRQREEAPMAKAISFVAKSGTGKTTLLEKVIAELKSRGYRVGAIKHDAHRFDIDHPGKDSYRLTAAGADTMLISSPEKLAVVKKHEVSPPIEELIATYFGDVDIIITEGFKKSGLPKIEVHRRERSTTLLCRGEQHDPTLLAVASDEPLELDVPVLDLNDPKQVADFVEERFLTQRS
The following text describes a protein:
Function:
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDRQQVTNARGERIAIVAGLRTPFAKQATAFHGISALDMGKMVVNELLVRSELDPKLIEQLVYGQVVQMPAAPNIAREIVLGTGMDVSTDAYSVTRACATSFQSAVNVAESIMTGNIEIGIAGGADSSSVLPIGVSKKLAHALVDLNKARTFGQKLQIFRRLGIKDLLPVPPAVAEYSTGLSMGQTAEQMAKTYNISRADQDALAHRSHTLANETWASGHLRDEVMVAHVPPYKQFIERDNNIRENSDLASYAKLRPAFDKKHGSVTAANSTPLTDGASAIILMSEGRAKALGYQPIGYIKSYAFTAIDVWQDMLMGPSYATPLALKRAGMELEDLTLIEMHEAFAAQTLANMQMFASKKFAEEKLGRNRAIGDIDMSKFNVLGGSLAYGHPFAATGTRLITQVCRELKRRGGGTGLATACAAGGLGAAMIVEVE
The following text describes a protein:
Function:
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Sequence:
MSHKQIYYSDKYDDDKYEYRHVMLPKEIAKRVPKTHLMSETEWRNLGVQQSQGWVHYMIHQPGIKLVITYILYKIWLFFSLNASLIFWDEKFLKCCQKGNWINKSDV
The following text describes a protein:
Function:
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSLSYSKLSQEMLWKLKVLTFSSGAIVMALEIATSRILTPVFGSTIYTWGSLIGVILSGLSLGYFLGGRIADKHPKFDKICGIVFSVGLFIVGMPFFASHVVDFSLAIMPISQYTPLLATFLLLMLPSVLLGFVSPYVIKLGTKSLQKVGNMSGNLYSIATVGSIFGTFVTVFVLIPNVTVHQIIFGLGIALIASSLIGLKISPKIIAIGIVIILIVPWSSFSVSTISHNGMLIFEKETMFSHLDIIEYGDNRSLYLDGLRHSSMNMRDPLDLVIDYTEYFHLGMMFNPAAKDILFVGGGGFSGPKNFLALYPDTKIDVIEIDSDVIDVAKTYFNLETNPRLQIFNDDARKHLSMFDKKYDLIILDAYATNYVPYHLMTHEFFQLLEKRLEPNGIVVSNLIGSIEGNNSPLVRSVYKTMKETFPVSYVFPTEEKPTFIQNIMIVSSNQPYEFDRLLLLELSKNSPVDYLSDELSRQEHFYTGIIATTDVPFLTDQYNPSEVLINPITKNPYLQDLPENQIDEKQHLEYSMNLILGIILIIIAGMWLFYFKKRIWNFN
The following text describes a protein:
Function:
Apoptosis-inducing protein that modulates the tumor suppressor function of CDKN2A/p14ARF. Enhances the stability of CDKN2A/p14ARF protein by protecting it from degradation. May act as a tumor suppressor.
Subcellular Localization:
Nucleus, nucleolus. Note=Colocalizes with CDKN2A/p14ARF in the nucleolus.
Sequence:
MGVRLRVWPAAPHSISRCPRPLGAVLSILLAGGSRKGTPTARCLGQRTKEKRVGGRSLRSEAGSGPCPTAGAQPTAPSSAWPPRLRPRTCPQMSGELPRVRPTRVGLSSLGSGPGHPPSGTRMCGERARNRRGRARRLTPEQPRIGASAGPGPPLPPARPRCSGSCHLPRPPQHLSPPQPGRVRMGAAEGSRRADTHHARRRRRARLPAPRSAST