The following text describes a protein:
Function:
Transcription factor. Required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. In response to oxidative stress and anoxia, required to up-regulate expression of stl-1 mRNA. Involved in regulating innate immunity, acting downstream of the pmk-1 p38/MAPK pathway and probably also downstream of nipi-3. Required for the up-regulation of phase II detoxification genes, including gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. Modulates oxidative stress responses in concert with transcription factors such as hcf-1 and elt-3. Regulates the transcription of genes associated with metabolism in response to changes in nutrient availability. In neurons, involved in mitochondrial fusion and behavioral recovery during reoxygenation. Required for riok-1 mRNA expression in the intestine. Downstream of the let-60/Ras, mek-2 and pmk-1 pathway, positively regulates lifespan probably by preventing transcription of insulin-like peptides such as ins-39. Prevents degeneration of dopaminergic CEP neurons in response to high Al(3+) or Mn(2+) levels, probably by promoting the expression of glutathione-S-transferase gst-1; [Isoform a]: Directed by the ER-associated degradation pathway (ERAD), mediates proteasomal homeostasis by regulating the expression of proteasomal subunits such as rpt-3 to confer resistance to proteasomal dysfunction.
Subcellular Localization:
Nucleus. Cytoplasm. Note=In absence of stress, localizes in the cytoplasm of intestinal cells. Upon paraquat or arsenite treatments or upon bacterial infection, localizes in the nucleus. Nuclear localization is regulated by pmk-1-mediated phosphorylation. Nuclear localization is regulated by transcriptional coregulator hcf-1; [Isoform a]: Nucleus. Mitochondrion. Note=Localizes to the nucleus in response to proteasomal dysfunction; [Isoform b]: Nucleus. Note=Localizes to the nucleus in response to pathogenic bacteria such as P.aeruginosa or E.faecalis, in a nipi-3-dependent manner. Localizes to the nucleus in a brap-2-dependent manner; [Isoform c]: Nucleus. Note=Localizes to the nucleus in response to pathogenic bacteria such as P.aeruginosa or E.faecalis, in a nipi-3-dependent manner. Localizes to the nucleus in a brap-2-dependent manner.
Domain:
Alternative DNA-binding strategy due to lack of a leucine zipper dimerization segment: DNA binding domain binds to its cognate half-site, an N-terminal arm recognizes adjacent 5' AT-rich sequences in the minor groove and the intervening residues stabilize interactions of these two subdomains with DNA.
Sequence:
MGGSSRRQRSTSATRRDDKRRRRQCFSSVADDEEETTSIYGVSSIFIWILATSSLILVISSPSSNTSIQSSSYDRITTKHLLDNISPTFKMYTDSNNRNFDEVNHQHQQEQDFNGQSKYDYPQFNRPMGLRWRDDQRMMEYFMSNGPVETVPVMPILTEHPPASPFGRGPSTERPTTSSRYEYSSPSLEDIDLIDVLWRSDIAGEKGTRQVAPADQYECDLQTLTEKSTVAPLTAEENARYEDLSKGFYNGFFESFNNNQYQQKHQQQQREQIKTPTLEHPTQKAELEDDLFDEDLAQLFEDVSREEGQLNQLFDNKQQHPVINNVSLSEGIVYNQANLTEMQEMRDSCNQVSISTIPTTSTAQPETLFNVTDSQTVEQWLPTEVVPNDVFPTSNYAYIGMQNDSLQAVVSNGQIDYDHSYQSTGQTPLSPLIIGSSGRQQQTQTSPGSVTVTATATQSLFDPYHSQRHSFSDCTTDSSSTCSRLSSESPRYTSESSTGTHESRFYGKLAPSSGSRYQRSSSPRSSQSSIKIARVVPLASGQRKRGRQSKDEQLASDNELPVSAFQISEMSLSELQQVLKNESLSEYQRQLIRKIRRRGKNKVAARTCRQRRTDRHDKMSHYI