lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MEDPQGGQDCSKFGAFVDKNSGASSSSAADIELQNMCGTSVARTASLSTGRASPSQFAPTVGRYHRAAGSCQSDVLPDEQSLASAFDMVLSFRNHPVDYPTNPCNVVPSNGLYVSGPMRATSVQSFDPLLVQDESMRPQFGAGHGKLKTDEFTVDQQEQAHMLSHYFGNWPQNYGMNNMGGVASTPYKPSASLYQQPFYMDEQSQMYAPYQQIPSNFLLQHDMDVQNHSSMQPHYVYPQMQHAAGSNVRSNQQAAACTSARGRSTYGHQLLLDGAVYHNGNNQMNSLYMDGFPGMYTDSSFDSSDFHRLLEAEKFAHPYELNSSSKGFLQPQIPDDLSTMKMLMNSAGVNRVRAIKFPPTVNGYSGVGRRTNGYGHNHLDVKSDETLHLNGLNSQFMSLKSEYDLAMKSTQLNYGSVDEVAGRIYMLAKDQNGCRFLQKVFTEGTKEDFEKILAEIIDHFGELMIDPFGNYLVQKLLEECSDDQRTRIICEITRVPGELITVACNMHGTRTVQKVIDTINTPEQISKVVSALSPGAMRLMTDTNGSHVAQRCLKKLLPEYKAFLLDVAALRFLRLAKDQHGCCIIQKCIEHSNDEQKYNLLCKITSSALSLSEDQYGNYVIQFVVNLGIEWATSKIVKELKGHFGYLSMQKCGSHVVENCLKQASELDREMIIHELMADSKLPHIMADPFGNFVIQTALKECKGELHSSFVEAIRPHAPALQNDVYAKRVLSKTYLKNKQYRLGIF
The following text describes a protein:
Function:
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Subcellular Localization:
Nucleus.
Sequence:
MGSEMNLIGHPQLATADGFSLAEGPHLFGILSEPMSSPVQEADVSPYTQYNSVPFPQVQPQISSPPYYSNLGFYPPQHEEWYSPGMYELRRIPSETFFTRETEIMDIPAAKKPRLGHSTGRMKGEELCVVCGDKASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCEMDMYMRRKCQECRLRKCKQMGMLAECLLTEIQCKSKRLRKNVKQLPDQTVNEDNEGHDMKQVTSTTKMYREKVEFTPEQQNLLDYIMDSYSKQQIPQEVSKKLLHEEFSAEGNFLILTEMATSHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFSRKLPTGHTVLLEERIRNSGISDEFITPMFNFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDRESVERLQEPLLDILQKFCKLHHPDNPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
The following text describes a protein:
Function:
Transcriptional coactivator of POU2F3. This complex drives the development of tuft cells, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Note=Recruited to chromatin by POU2F3.
Domain:
In the N-terminus, possesses a conserved OCA domain for bivalent binding to class II POU domain-containing transcription factors and to an octamer DNA motif (5'-ATGAAAT-3').
Sequence:
MESVPGDYSKRVYQGVRVKHTVKDLLAEKRSGQTSNSRLNGSVSSSQSPFVQMPGSPVTSGYYGVRRSFLSDSDFHNSKQFSNDVYTSSVGKPFPCESSAGQSHAALLEPYFPQEPYGDYRPPALTPNAGSLFSASPLPPLLPPPFPGDPAHFLFRDSWEQTLPDGLSQPDPVSADALLTLPPSTSCLSQLESGSIAQHRGSSWGSSLAGAQSYSLHALEDLHHTPGYPTPPPYPFTPFMTVSNDLPPKVGPLSPDEEADTGSLHDPSPWVKEDGSIAWGSYECRRAY
The following text describes a protein:
Function:
Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGAACEPVARPSLTSISSGELRSLWTCDCELALLPLAQLLRLQPGAFQLSGDQLVVARPGEPAAARGGFNVFGDGLVRLDGQLYRLSSYIKRYVELTNYCDYKDYRETILSKPMLFFINVQTKKDTSKERTYAFLVNTRHPKIRRQIEQGMDMVISSVIGESYRLQFDFQEAVKNFFPPGNEVVNGENLSFAYEFKADALFDFFYWFGLSNSVVKVNGKVLNLSSTSPEKKETIKLFLEKMSEPLIRRSSFSDRKFSVTSRGSIDDVFNCNLSPRSSLTEPLLAELPFPSVLESEETPNQFI
The following text describes a protein:
Function:
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSELKSRIGNSGSIANSGPVSILCYCASSILMTVTNKFVVNTDGFNMFFVMLFAQSLVCTMCLMVLKMFGYAKYRPLNLIDVKNWLPISFLLVFMIFTSAKALKYMPVPIYTIFKNLTIILIAYGEVLFFGGSVTPMELSSFILMVLSSVVASLGDQQAAKIAQPLANNSILSPEYYWMFLNCICSASFVLIMRKRIKLTNFKDYDTMFYNNALALPILLGFSFLSEDWSSENLAQNFSGESLSAMIISGMTSVGISYCSGWCVRATSSTTYSMVGALNKLPIALAGLIFFDAPRNFLSIMSIFIGFASGLSYAVAKQKKVQKN
The following text describes a protein:
Function:
Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.
Subcellular Localization:
Cytoplasm.
Sequence:
MGGQSGPTMDSGDFFDQSEFVPSSKSNAPSKPVQDRSSSSSGNEAGKMVVGNGSPDSYKVVFIKDNVSVHPTQNASERISGRLRLIKQGASLFMTWIPYTVQGAARRGTSIMKSTEKDRNLYTIRAVSLAEMRSIRRHTPPFGLQYVIIVLTSGLAFPPLYFHTGGVREFLSTLRNHALLVRSNDDSNVYLVNDVQDPLQRSLTSLELTEVTPVSVITPAAEPPPVVTKEDDVEPVPEESITSSSMHTSVYRQGVRREASREIINVLEKFSMVTKFARDTTAHLFGESRFLGNSEMDLDRAPMRLRNDDASKSNIEFQTLNRPQESNSDGKEAVAKGEDETHRRLTGVEKEKIERGEKEKKEEKEEKKKSAEEEAATNVGTFELVDGTQNDSPALVWGRARPPPLGHEEWATFLDSEGRVVDPKALKKRVFHGGVEPNLRPELWKFLLGHYKFDSTYAEREALVALKREEYKVLQTQWKTVSEDQARRFAKFRERKHRVEKDVVRTDRTIPFYEGDDNKNVDILRDILVTYSFYNFDLGYCQGMSDLLSPILHVVVEESEAFWCFAALMERMAPNFHRDQAGMQAQLSAVSKLVQLLDNPLHDYFKQNDCLNYFFCFRWILICFKREFDYNDVLRLWEVLWSHYLSEHFHLYMCVAILKRHRRKIMDEQMEFDTLLKFINELSGHIELESTLRDTEALCLFAGEKGTACIPPGTPPSLPVVEVDAFPMSL
The following text describes a protein:
Function:
Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity. Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Nucleus, nucleolus. Nucleus, PML body. Note=Primarily localizes to the nucleolus. Also localizes to the PML nuclear bodies, when desumoylated.
Domain:
The CoCUN region mediates binding to ubiquitin. Does not interact with NEDD8.
Sequence:
MAARAVLDEFTAPAEKAELLEQSRGRIEGLFGVSLAVLGALGAEEPLPARIWLQLCGAQEAVHSAKEYIKGICEPELEERECYPKDMHCIFVGAESLFLKSLIQDTCADLCILDIGLLGIRGSAEAVVMARSHIQQFVKLFENKENLPSSQKESEVKREFKQFVEAHADNYTMDLLILPTSLKKELLTLTQGEENLFETGDDEVIEMRDSQQTEFTQNAATGLNISRDETVLQEEARNKAGTPVSELTKQMDTVLSSSPDVLFDPINGLTPDEEALSNERICQKRRFSDSEERHTKKQFSLENVQEGEILHDAKTLAGNVIADLSDSSADSENLSPDIKETTEEMEYNILVNFFKTMGYSQEIVEKVIKVYGPSTEPLLLLEEIEKENKRFQEDREFSAGTVYPETNKTKNKGVYSSTNELTTDSTPKKTQAHTQQNMVEKFSQLPFKVEAKPCTSNCRINTFRTVPIEQKHEVWGSNQNYICNTDPETDGLSPSVASPSPKEVNFVSRGASSHQPRVPLFPENGLHQQPEPLLPNNMKSACEKRLGCCSSPHSKPNCSTLSPPMPLPQLLPSVTDARSAGPSDHIDSSVTGVQRFRDTLKIPYKLELKNEPGRTDLKHIVIDGSNVAITHGLKKFFSCRGIAIAVEYFWKLGNRNITVFVPQWRTRRDPNVTEQHFLTQLQELGILSLTPARMVFGERIASHDDRFLLHLADKTGGIIVTNDNFREFVNESVSWREIITKRLLQYTFVGDIFMVPDDPLGRSGPRLEEFLQKEVCLRDMQPLLSALPNVGMFDPSFRVPGTQAASTSHQPPTRIQGAPSSHWLPQQPHFPLLPALPSLQQNLPMPAQRSSAETNELREALLKIFPDSEQRLKIDQILVAHPYMKDLNALSAMVLD
The following text describes a protein:
Function:
Hydrolase that converts various nucleotide triphosphates (NTPs) to the corresponding nucleotide monophosphates and diphosphate, and nucleotide diphosphates to nucleotide monophosphates and inorganic phosphate. Has a marked preference for cytosine ribonucleoside 5'-diphosphate (CDP) and cytosine ribonucleoside 5'-triphosphate (CTP). Has lower activity towards the deoxyribose nucleotides dCDP and dCTP, and towards dGDP, TDP and UDP.
Sequence:
MGGVSDERLDLVNERDEVVGQILRTDPALRWERVRVVNAFLRNSQGQLWIPRRSPSKSLFPNALDVSVGGAVQSGETYEEAFRREAREELNVEIDALSWRPLASFSPFQTTLSSFMCVYELRSDATPIFNPNDISGGEWLTPEHLLARIAAGEAAKGDLAELVRRCYREEE
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular Localization:
Midbody, Midbody ring.
Sequence:
MDHLGYSGGISRVGIQHNRYSGQFSDRYSQYSESEYDPSETTHSESDSENHHHSNIPILEYPSFLSQSNDNVSNGPSNNTLSSSATSLGNNDGDEDLENVINNYLSFEKDVDILTERLGKTLSTLETEMIVGVLDSGVGVNEVISQLGDKDGTHLTGVTAWIEYYNKQLQDMKKYIEHIEGKNNKMEIVSRNQKLLYSELNNLIGLMTLSDNTISTLTAPQFNDTKGLKMAIEAAEDLKRALTTKLKSGMDNMMAVKDQRKVFETYKISFARKVAALVENIFKTTDKEIGKHVITTTSQTPGEEKFPDYLEYYDLLRKFKPLVNWLKEMDHEKLIPLIVSYIKAFRRIYESDIKLFFSTIQQSLEKESKDQNDFFSSSSSSKKSIDSLNNNTSTSTPSKNSSSSSSSSSGKDGIKKRKINRLFKYALSCLEIYIMTKQNFVMDFFLYQDPPRLAGQRNHHSNSSGGGSGSNKDGKDRKDKKSSKKDKKDKKDKKDKKDKKKKDPDSSSSPSLDNDKPIDSNSPKSPNNAVNGSLSSTEESSPPPPPPPPPKESPDAPLDLILSAMFNGVVPELINMVEKADQVNPFYLLTMLLETELYIDAHSRKDSHHSSYFVKILAEVQKSIKTLFNKFLEVQVDAIKSTQTSLKRCGVLPHFRNFHIFVKELQKYKSESDTGSSTLLIESSYKKIILELFNWLDGLVEKLPEDKKYKFISKLENHYFFYLKLQELNINCLTQHKDTSQSIFKENLEIYVNFLIDLKFKPLIEYYTKMDELLLTLPPSDIQFQQSHSKQQFKKIVEKFKTENIEKGLLKALGNVQKNITKDSQLILVIWERLEEVFIEKYEHFQDITSDCYNQTMPVSSDQIKGIFGTVYKKNPNKH
The following text describes a protein:
Function:
ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity.
Subcellular Localization:
Nucleus.
Sequence:
MPAAGPPLLLLGTPGSGKTALLFAAALEAAGEGQGPVLFLTRRPLQSMPRGTGTTLDPMRLQKIRFQYPPSTRELFRLLCSAHEAPGPAPSLLLLDGLEEYLAEDPEPQEAAYLIALLLDTAAHFSHRLGPGRDCGLMVALQTQEEAGSGDVLHLALLQRYFPAQCWLQPDAPGPGEHGLRACLEPGGLGPRTEWWVTFRSDGEMMIAPWPTQAGDPSSGKGSSSGGQP
The following text describes a protein:
Function:
Involved in de novo bacterial ceramide synthesis. Catalyzes the condensation of L-serine with palmitoyl-CoA (hexadecanoyl-CoA) to produce 3-oxosphinganine (By similarity). Also capable of using alanine as substrate leading to the formation of 1-deoxysphinganine (1-deoxySa). Contributes to the levels of endogenous sphingolipids in its host.
Miscellaneous:
MISCELLANEOUS: The bacterial ceramide synthesis pathway operates in a different order from that in eukaryotes. Furthermore, phylogenetic analyses support the hypothesis that the bacterial and eukaryotic ceramide pathways evolved independently.
Sequence:
MGLLQEKLAKYDLPQKFMAQGVYPYFREIEGKQGTEVEMGGHEVLMFGSNAYTGLTGDERVIEAGIKAMHKYGSGCAGSRFLNGTLDLHVQLEKELAAFVGKDEALCFSTGFTVNSGVIPALTDRNDYIICDDRDHASIVDGRRLSFSQQLKYKHNDMADLEKQLQKCNPDSVKLIIVDGVFSMEGDLANLPEIVRLKHKYNATIMVDEAHGLGVFGKQGRGVCDHFGLTHEVDLIMGTFSKSLASIGGFIAADSSIINWLRHNARTYIFSASNTPAATASALEALHIIQDEPERLEALWEATNYALKRFREAGFEIGATESPIIPLYVRDTEKTFMVTKLAFDEGVFINPVIPPACAPQDTLVRVALMATHTKDQIDRAVEKLVKAFKALDLL
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MRFSKSIWIRILLDRKLRGITSLIRRINASMYTCTDIQKAMKGLRKAFSNRCMSPAVPEHEGEAKHIKSETVTALEPIIAKWNVDKITPTSNLNHNREDIRVFIDAISQLNNHMNLAVNDATARRDLAHAHRLMQIAMKRMQKELSHILSVNRDLLDSDSIQSTVSTTITSISDSDFEESSHGVSPDEEIKYVGESTLGRVNNEAHSQAVMADLKSLAECMVTSGYTKECTNIYKNIRKSIVQEGIYRLGFHRSNQSDIQNLDWDVTVELWLAASRIAIKNIFSSERALCDYVFSTSSPHIRELCFAEITKDVAVEFLHLPELMATTKSKTPETTCRILDLYSTVSDLFPDIESVFNYDSTSTIRSQATASLNKLMKYIRTAFSDLESKVQNATSKGAVRGGGLYPLTRETMDYLVLLSEYQAALDSIFAGHPHPNLPSSPTDVEPSIPSISTRLEWLLLVLVCKLDAKAEAYKNAPLSYIYLANNYQYIVSKVRGSNLVHLLGEKWVAKHEEKILCFITGYENTAWAKVMTAIEEENINKFNSEFRDAWRKQGKWALVEEGGMRTKILASVKRKVMIPYLELCLKRTDEENRNAEESGDDVIRFLPEDLEEYMEGLFRGTILLEGNDESSSHSGLGSGSFNLSRYRSSGSGFWRS
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MGTLLARVAVVALAAAAAAVVVDGQMSPAFYDATCPALQSVVRRGMAQAVQKEARMGASILRLFFHDCFVNGCDASVLLDDTANFTGEKNAGPNANSLRGYEVIDAIKAQVEASCKATVSCADIVALAARDAVSLVGTHFSLPLFLASWPVALLKAAACVQLGGPSWTVQLGRRDGRSASQNAANTNLPPPDARLADLLTRFSDKGLDARALTALSGAHTVGWARCTTFRTHIYNDTGNAAVDAAFATQIRAKACPSAGGDGNLAPLELRAPAAFDNGYFQDLVARRVLLRSDQELYGSGVGDGSTDALVRAYAANATLFAVDFAAAMVRMGNLALTGKNGEVRLNCRRVN
The following text describes a protein:
Function:
Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III. Has weaker activity with coproporphyrin I, protoporphyrin IX, deuteroporphyrin, 2,4 hydroxyethyl and 2,4 disulfonate.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MQFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPAERLDAVAEHYLHFGGVSPINGINRTLIAELEAQQELPVYFGNRNWEPYVEDAVTAMRDNGVRRAAVFATSAWSGYSSCTQYVEDIARARRAAGRDAPELVKLRPYFDHPLFVEMFADAITAAAATVRGDARLVFTAHSIPTAADRRCGPNLYSRQVAYATRLVAAAAGYCDFDLAWQSRSGPPQVPWLEPDVTDQLTGLAGAGINAVIVCPIGFVADHIEVVWDLDHELRLQAEAAGIAYARASTPNADPRFARLARGLIDELRYGRIPARVSGPDPVPGCLSSINGQPCRPPHCVASVSPARPSAGSP
The following text describes a protein:
Function:
Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
Subcellular Localization:
Cytoplasm. Nucleus, nucleoplasm.
Sequence:
MQQGHFTSNSYHSKTLNSSSLPVSSKFSHTNDPDVEGVDNDSFSKALCNKDLDPSSTIRSVISSLLDSLQDKALQQSPNTSLSKLLLEDQDFGSLWLSLSFIFCNYWQPAMLILDSKSIHPLPLTDGEVLHRWECEVDSNNKTTIDLKYWYCSCSQFSYNAFNSSRSFDEPMPKNEQETWGGRCLSHHPTICSHILAASILRACHNLVI
The following text describes a protein:
Function:
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
Sequence:
MIDAAQIDHLTALARLELSPAERRTMQQDLTRMLGYFEQLGRVPTEGVQEMQRPVSLVNVLRDDAPGETFPSGVVSALAPETQDGFIRVPRTVDTE
The following text describes a protein:
Function:
May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPQAPNDMELLSTMMKRITQLEKQVAFYSKEVVEKDTRIKILEDKLALFKNKESKESDEPGKVAQLEMKCLQLQQEIYEMEAFLADYGMIWVGEKSNPNSKEYLENDDDSVPVATVTDGSWAQGKTIYPPPENFKVDYDLVLRNIQELNIIAGDGQADIVKTKGGAKLQAQKTVPLILYANGIMLFNGPFRPLSDVTTQRCLCDITDGYFPSELQERYPDGVPIQVTDKRHIKFKDARKAEIFPGVGRSLLDKDNIAKNLEESSELPGLRMSVEQFLDKVPKSVIRGGKVVDIRSSLKESLTDSTRGKVTTEIVETEAVKNMQHRMEIPQQERPVSARDVTTIRVKSEDGSKIFILKLKFSDTIQDLRNYIKKQRPRHREPYDILSTFPNQKHSDLKKTMQDSGLVPNATLFLKRK
The following text describes a protein:
Function:
Positively regulates the expression of the arcABDCR operon under anaerobic conditions, by binding to the consensus motif 5'-TGTGAN(6)TCACA-3', thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP.
Subcellular Localization:
Cytoplasm.
Sequence:
MTENFILGRNNKLEHELKALADYINIPYSILQPYQSECFVRHYTKGQVIYFSPQESSNIYFLIEGNIIREHYNQNGDVYRYFNKEQVLFPISNLFHPKEVNELCTALTDCTVLGLPRELMAFLCKANDDIFLTLFALINDNEQQHMNYNMALTSKFAKDRIIKLICHLCQTVGYDQDEFYEIKQFLTIQLMSDMAGISRETAGHIIHELKDEKLVVKDHKNWLVSKHLFNDVCV
The following text describes a protein:
Function:
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Also involved in chromosome segregation in meiosis.
Subcellular Localization:
Nucleus. Note=Associates with chromatin.
Domain:
The SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with a SMC2 subfamily member, forming a V-shaped heterodimer.
Sequence:
MEEDEPMGGGESEPEQRKSGTPRLYIKELVMRNFKSYAGEQRVGPFHKSFSAVVGPNGSGKSNVIDAMLFVFGKRAKQMRLNKVSELIHNSTNHQNLDSAGVSVQFEEIIDLENGLYETVPGSDFMITRVAFRDNSSKYYINERSSNFTEVTKKLKGKGVDLDNNRFLILQGEVEQISLMKPKAQGPHDEGFLEYLEDIIGTNKYVEKIDELNKQLETLNESRSGVVQMVKLAEKERDNLEGLKDEAETYMLKELSHLKWQEKATKMAYEDTVAKITEQRDSLQNLENSLKDERVKMDESNEELKKFESVHEKHKKRQEVLDNELRACKEKFKEFERQDVKHREDLKHVKQKIKKLEDKLEKDSSKIGDMTKESEDSSNLIPKLQENIPKLQKVLLDEEKKLEEIKAIAKVETEGYRSELTKIRAELEPWEKDLIVHRGKLDVASSESELLSKKHEAALKAFTDAQKQLSDISTRKKEKAAATTSWKADIKKKKQEAIEARKVEEESLKEQETLVPQEQAAREKVAELKSAMNSEKSQNEVLKAVLRAKENNQIEGIYGRMGDLGAIDAKYDVAISTACAGLDYIVVETTSSAQACVELLRKGNLGFATFMILEKQTDHIHKLKEKVKTPEDVPRLFDLVRVKDERMKLAFYAALGNTVVAKDLDQATRIAYGGNREFRRVVALDGALFEKSGTMSGGGGKARGGRMGTSIRATGVSGEAVANAENELSKIVDMLNNIREKVGNAVRQYRAAENEVSGLEMELAKSQREIESLNSEHNYLEKQLASLEAASQPKTDEIDRLKELKKIISKEEKEIENLEKGSKQLKDKLQTNIENAGGEKLKGQKAKVEKIQTDIDKNNTEINRCNVQIETNQKLIKKLTKGIEEATREKERLEGEKENLHVTFKDITQKAFEIQETYKKTQQLIDEHKDVLTGAKSDYENLKKSVDELKASRVDAEFKVQDMKKKYNELEMREKGYKKKLNDLQIAFTKHMEQIQKDLVDPDKLQATLMDNNLNEACDLKRALEMVALLEAQLKELNPNLDSIAEYRSKVELYNGRVDELNSVTQERDDTRKQYDELRKRRLDEFMAGFNTISLKLKEMYQMITLGGDAELELVDSLDPFSEGVVFSVRPPKKSWKNIANLSGGEKTLSSLALVFALHHYKPTPLYVMDEIDAALDFKNVSIVGHYVKDRTKDAQFIIISLRNNMFELADRLVGIYKTDNCTKSITINPGSFAVCQKTPA
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MDGATESGAASSPVVVFKRKRGRASQGTSSTLTNVATSSQAGPSGASRAHSDSGSSRSDSESGSTVVIKKKRRSANPLVQSTGRVYRKLKLSGSLDGEKENSVDADESGDAGLTSSSIASSSLQKMREDATRNSDWDLDTAGTLKETGVTSNSDGLYRGAKSYASFTRTRDDGCSSKMRSRGPIRQTTTVRTTSLIDYQPDVCKDYKETGYCGFGDTCKFLHDRSDYLAGWQLDVLPNSSSRTRENMLSDPEDSDTEDDIPFACLICRKAFTDPVVTRCAHYFCSSCAIKRFAKNSKCFACGQQTGGLFNSAKKVLERMDKLKQQKAQLRREKHEWLQDPQPTHQLATAGDSDVD
The following text describes a protein:
Function:
Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CGAS and SNAI1. The ECS(SPSB3) complex catalyzes 'Lys-48'-linked ubiquitination of nuclear CGAS in cycling cells, leading to its degradation. Recognizes and binds nucleosome-bound CGAS: ubiquitination and degradation of nuclear CGAS during G1 and G2 phases is required to promote low intranuclear CGAS abundance before the next mitotic cycle. The ECS(SPSB3) complex also mediates ubiquitination and degradation of phosphorylated SNAI1.
Subcellular Localization:
Nucleus.
Sequence:
MARRARSSRAWHFVLSAARRDTDARAVALAGNSNWGYDSDGQADWLLVQWICLGFGRSHLCQWGTRSALSDSDSDPEYSSLPPSIPSAVPVTGESFCDCEGQNEATFCNSLHTAHRGKDCRCGEEDEDFDWVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGDGQHFWEIKMTSPVYGTDMMVGIGTSDVDLDKYHHTFCSLLGRDEDSWGLSYTGLLHHKGDKTSFSSRFGQGSIIGVHLDTWHGTLTFFKNRKCIGVAATRLQNRRFYPMVCSTAAKSSMKVIRSCASSTSLQYLCCYRLRQLRPDSGDTLEGLPLPPGLKQVLHNKLGWVLSMNCSHWTSPAPPPGTAAPAAERDSRETRPCQRKRCRRS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. It has an important role in the negative regulation of Ty transcription.
Miscellaneous:
MISCELLANEOUS: Present with 606 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSAAPVQDKDTLSNAERAKNVNGLLQVLMDINTLNGGSSDTADKIRIHAKNFEAALFAKSSSKKEYMDSMNEKVAVMRNTYNTRKNAVTAAAANNNIKPVEQHHINNLKNSGNSANNMNVNMNLNPQMFLNQQAQARQQVAQQLRNQQQQQQQQQQQQRRQLTPQQQQLVNQMKVAPIPKQLLQRIPNIPPNINTWQQVTALAQQKLLTPQDMEAAKEVYKIHQQLLFKARLQQQQAQAQAQANNNNNGLPQNGNINNNINIPQQQQMQPPNSSANNNPLQQQSSQNTVPNVLNQINQIFSPEEQRSLLQEAIETCKNFEKTQLGSTMTEPVKQSFIRKYINQKALRKIQALRDVKNNNNANNNGSNLQRAQNVPMNIIQQQQQQNTNNNDTIATSATPNAAAFSQQQNASSKLYQMQQQQQAQAQAQAQAQAQAQAQAQAQAAQAAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAHAQHQPSQQPQQAQQQPNPLHGLTPTAKDVEVIKQLSLDASKTNLRLTDVTNSLSNEEKEKIKMKLKQGQKLFVQVSNFAPQVYIITKNENFLKEVFQLRIFVKEILEKCAEGIFVVKLDTVDRLIIKYQKYWESMRIQILRRQAILRQQQQMANNNGNPGTTSTGNNNNIATQQNMQQSLQQMQHLQQLKMQQQQQQQQQQQQQQQQQQQQQQQHIYPSSTPGVANYSAMANAPGNNIPYMNHKNTSSMDFLNSMENTPKVPVSAAATPSLNKTINGKVNGRTKSNTIPVTSIPSTNKKLSISNAASQQPTPRSASNTAKSTPNTNPSPLKTQTKNGTPNPNNMKTVQSPMGAQPSYNSAIIENAFRKEELLLKDLEIRKLEISSRFKHRQEIFKDSPMDLFMSTLGDCLGIKDEEMLTSCTIPKAVVDHINGSGKRKPTKAAQRARDQDSIDISIKDNKLVMKSKFNKSNRSYSIALSNVAAIFKGIGGNFKDLSTLVHSSSPSTSSNMDVGNPRKRKASVLEISPQDSIASVLSPDSNIMSDSKKIKVDSPDDPFMTKSGATTSEKQEVTNEAPFLTSGTSSEQFNVWDWNNWTSAT
The following text describes a protein:
Function:
DNA ligase, which is expressed in the early stage of lytic development, has been implicated in T4 DNA synthesis and genetic recombination. It may also play a role in T4 DNA repair.
Sequence:
MILKILNEIASIGSTKQKQAILEKNKDNELLKRVYRLTYSRGLQYYIKKWPKPGIATQSFGMLTLTDMLDFIEFTLATRKLTGNAAIEELTGYITDGKKDDVEVLRRVMMRDLECGASVSIANKVWPGLIPEQPQMLASSYDEKGINKNIKFPAFAQLKADGARCFAEVRGDELDDVRLLSRAGNEYLGLDLLKEELIKMTAEARQIHPEGVLIDGELVYHEQVKKEPEGLDFLFDAYPENSKAKEFAEVAESRTASNGIANKSLKGTISEKEAQCMKFQVWDYVPLVEIYSLPAFRLKYDVRFSKLEQMTSGYDKVILIENQVVNNLDEAKVIYKKYIDQGLEGIILKNIDGLWENARSKNLYKFKEVIDVDLKIVGIYPHRKDPTKAGGFILESECGKIKVNAGSGLKDKAGVKSHELDRTRIMENQNYYIGKILECECNGWLKSDGRTDYVKLFLPIAIRLREDKTKANTFEDVFGDFHEVTGL
The following text describes a protein:
Function:
E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress. Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis. Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens. Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR. Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2. Upon stimulation by ligand EFNB1, ubiquitinates EPHB2 and further recruits MAP1LC3B for autophagy induction. Controls nutrient sensing by ubiquitinating Sestrin-2/SESN2, which is an intracellular sensor of cytosolic leucine and inhibitor of mTORC1 activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The RING-type domain is required for ubiquitination.
Sequence:
MACLEIPQQPQLVCQKATPSDPAGCDGGPGGPTEGDLECLVCREPYSGVRPPKLLGCQHAFCAVCLKLLLCVQDDAWSIPCPLCRKVTAVPGGLVCTLRDQEKVLERLARPGLEVPLRPQGLANPATLTAGQPREAGEEEQDAVTTNRAAARRLAAHLLLLVLLIILILPFIYPGVIRWVLSFLETLALLLALLFCSHPGQQDGCMPTPRTLFCRERKPSEIASIS
The following text describes a protein:
Function:
Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.
Sequence:
MNPELACKQAKRLIRVAEKKKLTDAQVAELQACLARLSQSKRARLEGLLKRVQGLSGPTTRQGTEDNKETNVLRPLSQFSIGRGESKSPAAVRETILRCVSFRHLARNKTAFELYNEFSCKGVLLLKLELTDDTKPDVFPILNAQYPFSVSLSSGTQISNTHYFETILEEDMCLRMQRITSIKDLLLESEQFTPFLYLPPQCIINNLADNWNGVLLAIDCEMIHTSVCENDLARVTVVECNTRTTTPVTSIFSLVYDAYVELPSDTEVVDYKTQYSGITAQILENASSKHPKDIIRDHILSFILPSELHELLYAEQIQHSTDLSALSGVSLPFIVGHGVENDLRALGLIYPLVIDTCVLYQHGTRKPRLQDLARRYLLKDIQTNAEAGHSSIEDAEAALHLVLLRLELSNIHISSILSRSLSSSSAGKAVQKYFNMLRERQIATLKESTASLSQLIYKYQVMKSEAISQYAYGVLSLYSFKSIQHFTLSGAKSPPTLGELLLWISTLPPQNRKFCIATPAPIPCSELLPYLRDIQAYVPPQILVLCVVHAGDITMCPFVSGADFEDVSSKNLLANKID
The following text describes a protein:
Function:
Hydrolyzes acetyl esters in homogalacturonan regions of pectin. In type I primary cell wall, galacturonic acid residues of pectin can be acetylated at the O-2 and O-3 positions. Decreasing the degree of acetylation of pectin gels in vitro alters their physical properties.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MGIYIPTTMADHWLKLLICVIALSSTKVNVRASEMVNITLLSNAVEKGAVCLDGSPAGYHYAKGYGDGANSWMIYLPGGGWCGRKQSCIDRVKYSPMLSSTKNITQENFGAILSPNKTSNPDFYNWNRVFIRYCDGSSFMGDVKKVDPETNLHKRGSRIFTSVIDELLSKGLKDAKNVMLTGNSAGGLATILNCDRFRALVPNANMVKCVSDSGFFIHAKNLPNAAGRERTFSRVVHFHGISKFLPKSCTSRMKPGLCFFPENLVAHIKTPLFLLNSDFDKFQIQVNLKPHPVDNPGWVNCTRNITTCTPPQLQIIKDFRNTFLETLKGVGNNPSRGLFINSCYIHDFLYLMGRYNSPDSPKLHNKTIAQAIGDWYFNRSSVRLIDTKIDYPLDCKIGSGNFV