lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MVFNWFNRFIKKDKKEEPTPEPTQAQEPVEAQPPAPVEEPAAEPDYMKWARLAQEKLNQELAAQPAVEPEAPAAFEEAPTAPPIEPPSAPAYDWQAVLYGTKSAAPVEPPPPSTATPPVTEAVIPPPPPPAVAPTPPAPEPPAAVSPAAFDWQAVLYGTRPAAPVEPPPAPQPPVAEAPPASVQAAPAFESPVVEVPEPPVAEPVVEPPVEEFPAAPVAEEEILPVESEPLTVAEVPVEPLPEAEVLPALLVAEEESAPVVEPPEPELPAAVEISPVFEAETVEAPAAEVLPPAEEPPTVEEVVPSVEAPPIFQPAAAESAPVEPPPPAPPAEPPPESPASAPLFDWRRILNRNRPVESPPEPPAPAAPEPPAAEAAPPAAEPPVFDWRRFLNRPRTPEAPPVQPPVVPEPPPAPEPVVPPPPAAAQTPPAQPKPRFELDPGFLWSAEVLAAQGRRPEDVTVEEISWLQKLRAGLGRTRRSLVNNVKALAGRGPIGPDELEELEGLLLQADVGITVSERILAALQERVRREALPGDQVMPFLKSQLRKQLELEGDDPTGFAPKRGQLNVWLIVGVNGVGKTTTIGKIAALATRSGYRTLIAAGDTFRAAAVEQLSIWGERSGVTVVANPSPKADPAAVVFDAISAAKARDVELLLVDTAGRLQNKKNLMDELAKVRRIIDKQAIDAHIESLLVLDATTGQNGLQQAKVFGETAGLTGVVITKLDGSAKAGIALAIVEQLQLPIRFVGVGEKIDDLRPFNSYEFVEALLSDYDAA
The following text describes a protein:
Function:
Methyltransferase; part of the gene cluster A that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA. 3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN. Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A. Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE. Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4. The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide. Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol. Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation. Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end products of the Emericella nidulans austinoid biosynthesis clusters are austinol and dehydroaustinol, even if additional enzymes, such as the O-acetyltransferase ausQ and the cytochrome P450 monooxygenase ausR are still functional.
Miscellaneous:
MISCELLANEOUS: In A.calidoustus, the austinoid gene cluster lies on a contiguous DNA region, while clusters from E.nidulans and P.brasilianum are split in their respective genomes. Genetic rearrangements provoked variability among the clusters and E.nidulans produces the least number of austionoid derivatives with the end products austinol and dehydroaustinol, while P.brasilianum can produce until acetoxydehydroaustin, and A.calidoustus produces the highest number of identified derivatives.
Sequence:
MIAMQPETQLKTALKNGFDPNILYKDPLTIVKEPMCTILEKHSKIPVDKVVSHVNKVRDRAFAVFPYACIGQFSFVELSIAASPYYPEMLERVKNGHKLLDLGCAFGQELRQLIYDGAPGESLYGSDIQQEFLNLGYELFLDRATLPESHLIASNILDRQSPLFTHLTGKLNIVYISLFLHVFDFEQQITVAGNVLDLLAAEPGSLIVCRVTACRDQGVLNATAERMPYYYHDRASWEQLWEVVQKRTGVKLCVDTWEQPDELVKKHPLPGIYILGSAIRRV
The following text describes a protein:
Function:
Involved in the biosynthesis of the dTDP-L-rhamnose which is an important component of lipopolysaccharide (LPS). Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well.
Sequence:
MNILLFGKTGQVGWELQRSLAPVGNLIALDVHSKEFCGDFSNPKGVAETVRKLRPDVIVNAAAHTAVDKAESEPELAQLLNATSVEAIAKAANETGAWVVHYSTDYVFPGTGDIPWQETDATSPLNVYGKTKLAGEKALQDNCPKHLIFRTSWVYAGKGNNFAKTMLRLAKERQTLSVINDQYGAPTGAELLADCTAHAIRVALNKPEVAGLYHLVAGGTTTWHDYAALVFDEARKAGITLALTELNAVPTSAYPTPASRPGNSRLNTEKFQRNFDLILPQWELGVKRMLTEMFTTTTI
The following text describes a protein:
Function:
Dehydrogenase; part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B. The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units. Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B. The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B.
Sequence:
MATNQAAWLTKAGNDLEVGDAPVPTAGPGEIVVKNAAVAINPLDTHMQDVGVFVQQWPTIFGCDVAGTVHETGPDVERFKKGDRVIGHAINLVTGRPQDGAYALYTVVPANKAAILPDAISFTDGVVAPFAVEAAVCVLSLKEPGVAMPGVSTPALALPYPSLDDPVKPLGKVLVIWGGSSSVGSMTTQIATAAGIQVIAISGAHNFELSKRCGATEVFDHKDPEVVDKVVAAVQKSGQEFVGIFDAVATPDTYTSDLVILEKLGGGHLAAVHPPPAEVPSNVKAGMIFAVNDIATPVWNDFVTPALESGKIQCLPPPTIVGKGLEAINEGLKRCKAGVSATKLVVEL
The following text describes a protein:
Function:
Has an important role in epithelial desmosome-mediated cell-cell adhesion.
Sequence:
MDDLYEANGSFAINLLKMLGREDSSRNVFCSPLSISSALAMVFMGAKGNTAAQMSQALCLSRDGDIHQGFRSLLAEVNKSGTQYLLRTANRLFGEETCDFLPAYRESCQKFYQAELEELSFAKDTEECREHINHWVTEKTEGKISEILGAGTVDALTKLVLVNAIYFKGKWHEQFDRKNTRGMPFKINQERKTVQMMFKQAKFKMGYVDDVHTQILELPYAGEELSMVILLPDDNTDLAEVEKALTYEKFRAWTDPENMTKNKVQVFLPRLKLEESYDLESFLRSVGMIDAFEEAKADFSGMSAKKNVSVSKVAHKCFVEVNEEGTEAAAATAVVRNARCSRAEPRFCADHPFLFFIIHRHTNSILFCGRFCSP
The following text describes a protein:
Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MVLQRLNEQRHRGLFCDIVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAYQKEVELVGASYIGLRTVIDFLYGSELSLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELASIYSLKRLDSFIDSFILRNFGTLSFTPDFLQNVSLQKLCQYLGSSLVQRECEHDLLQAALQWLTQYPEREADAFQVLENIHFPLIPKSDLLHRVKPAVCSLLPKEANCEGFIEEAVAYHNNVAAQPVLQNKRTSLRTNEERLLFVGGEVSERCLELSDDTCFLDAKNDQWVMETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRWNQWIKVASMNQRRVDFYLASISDMLVAVGGRNENGALSSVEAYSPKNDSWSYVAGLPRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEEKRPMITARGWHSMCSLEDSIYSIGGSDDNIESMERFDILSVESYSPQCNQWTRVSPLLQANSESGVAVWEGKIYILGGYSWENTTFSKTVQVYDREKNKWIKGTDLPKAIAGVSACVCSLKPRPEDKKKKPKTKRHQDRGR
The following text describes a protein:
Function:
Participates in a pentose oxidation pathway that converts D-arabinonate to 2-oxoglutarate.
Sequence:
MHFIMMKLFRVVKRGYYISYAILDNSTIIRLDEDPIKALMRYSENKEVLGDRVTGIDYQSLLKSFQINDIRITKPIDPPEVWGSGISYEMARERYSEENVAKILGKTIYEKVYDAVRPEIFFKATPNRCVGHGEAIAVRSDSEWTLPEPELAVVLDSNGKILGYTIMDDVSARDLEAENPLYLPQSKIYAGCCAFGPVIVTSDEIKNPYSLDITLKIVREGRVFFEGSVNTNKMRRKIEEQIQYLIRDNPIPDGTILTTGTAIVPGRDKGLKDEDIVEITISNIGTLITPVKKRRKIT
The following text describes a protein:
Function:
May have a photoreceptor function.
Sequence:
MADAVESMIQRYSSAGSSRNGKGVSIMWFRNDLRIVDNEALFKAWASSSSVLPVYCVDPRHFGTTHYFKFPKTGELRAQFLLESLVDLKKNLKKRGLDLVIRSGNPEFILPSLVEAVGADTIYAQEETCSEELQVEKAVKKSIGTKAKLELVWGTTMYHLNDLPFTTARLPDVYTQFRKAVESSSRVRPCLKLPQTLGPLPDSLGEKVGDLDKVPNLSHLGLRPREQSSLAAMQFAGGETAAIQRLCEYFWTKNCLRNYKETRNGMLGADYSTKFSPWLASGSISPRFIHEEASIKYEKERTANNSTYWVLFELIWRDYFRFLSMKYGNSIFHLEGPRKVRTKSWSQDKTLFEAWRTGTTGYPLIDANMKELYATGFMSNRGRQIVCSFLVRDMGIDWRMGAEWFESCLLDYDPCSNYGNWTYGAGVGNDPREDRYFSIPKQAQTYDPDGSYVSHWIPQLQELPTDARHFPKVGYLKKIVPLRFSNPGRTSKTSANFRK
The following text describes a protein:
Function:
Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKIENLKWKNVSFKSLEIDPDAGVVLVSVEKFSEEIEDLVRLLEKKTRFRVIVNGVQKSNGDLRGKILSLLNGNVPYIKDVVFEGNRLILKVLGDFARDRIASKLRSTKKQLDELLPPGTEIMLEVVEPPEDLLKKEVPQPEKREEPKGEELKIEDENHIFGQKPRKIVFTPSKIFEYNKKTSVKGKIFKIEKIEGKRTVLLIYLTDGEDSLICKVFNDVEKVEGKVSVGDVIVATGDLLLENGEPTLYVKGITKLPEAKRMDKSPVKRVELHAHTKFSDQDAITDVNEYVKRAKEWGFPAIALTDHGNVQAIPYFYDAAKEAGIKPIFGIEAYLVSDVEPVIRNLSDDSTFGDATFVVLDFETTGLDPQVDEIIEIGAVKIQGGQIVDEYHTLIKPSREISRKSSEITGITQEMLENKRSIEEVLPEFLGFLEDSIIVAHNANFDYRFLRLWIKKVMGLDWERPYIDTLALAKSLLKLRSYSLDSVVEKLGLGPFRHHRALDDARVTAQVFLRFVEMMKKIGITKLSEMEKLKDTIDYTALKPFHCTILVQNKKGLKNLYKLVSDSYIKYFYGVPRILKSELIENREGLLVGSACISGELGRAALEGASDSELEEIAKFYDYIEVMPLDVIAEDEEDLDRERLKEVYRKLYRIAKKLNKFVVMTGDVHFLDPEDARGRAALLAPQGNRNFENQPALYLRTTEEMLEKAIEIFEDEEIAREVVIENPNRIADMIEEVQPLEKKLHPPIIENADEIVRNLTMKRAYEIYGDPLPEIVQKRVEKELNAIINHGYAVLYLIAQELVQKSMSDGYVVGSRGSVGSSLVANLLGITEVNPLPPHYRCPECKYFEVVEDDRYGAGYDLPNKNCPRCGAPLRKDGHGIPFETFMGFEGDKVPDIDLNFSGEYQERAHRFVEELFGKDHVYRAGTINTIAERSAVGYVRSYEEKTGKKLRKAEMERLVSMITGVKRTTGQHPGGLMIIPKDKEVYDFTPIQYPANDRNAGVFTTHFAYETIHDDLVKIDALGHDDPTFIKMLKDLTGIDPMTIPMDDPDTLAIFSSVKPLGVDPVELESDVGTYGIPEFGTEFVRGMLVETRPKSFAELVRISGLSHGTDVWLNNARDWINLGYAKLSEVISCRDDIMNFLIHKGMEPSLAFKIMENVRKGKGITEEMESEMRRLKVPEWFIESCKRIKYLFPKAHAVAYVSMAFRIAYFKVHYPLQFYAAYFTIKGDQFDPVLVLRGKEAIKRRLRELKAMPAKDAQKKNEVSVLEVALEMILRGFSFLPPDIFKSDAKKFLIEGNSLRIPFNKLPGLGDSVAESIIRAREEKPFTSVEDLMKRTKVNKNHIELMKSLGVLGDLPETEQFTLF
The following text describes a protein:
Function:
FMRFamides and FMRFamide-like peptides are neuropeptides; SPSAKWMRF-amide: Acts as a ligand for the npr-22 receptor in vitro.
Subcellular Localization:
Secreted.
Sequence:
MNRSMIALCVVLMVSLVSAQVFDLDGQQLAGLEQNDARLMEQQVKRSPSAKWMRFGKRSPSAKWMRFGKRSPSAKWMRFGKRSGAEAVSEQDY
The following text describes a protein:
Function:
In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.
Subcellular Localization:
Endosome, multivesicular body membrane; Peripheral membrane protein. Prevacuolar compartment membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Sequence:
MPQAPKSLSIDSDAAVVAAAAADDLVRASSPRPRTTTFTPSRPTVLLTKSWTSATVLPSTTSTRITVGANTSTATDAASSISQHEPSTSSNSTRASTPLPELSPSPFSPQTAVAEALTREQQPAGPSDDSQSRSILPHASDHSTPCNSDQATEVAFHDAADVEPEAVGTTVSSSIHALDLLHRVNDRAAAERASNSESLRSHLSRLSVSRASSKHRSRSNSRDASTQTRALPPAFLGTKQAAPSAASAVTQTSLRDEAKDGDRQLYDTSSAPSHEEEQYPDRKYYILSSAGKPIYISHASLSRRKRRREKRRRQRRAESNESDLNSNESDEEDESSTTQVGVMQALISIFADEDSDKLRFIRRGDLLITFLLRAPLYLVCVSSWNEEPSTLRQHLEYLYLQVISLVSASQLTRLFGRMPNFDLRRLLEGTEGIFDYLVNQLNANETEDDDAEQGQHQVATGGVEAKRAVTDWASCHQWWLQALQPIRITVPNLRDQLTAALQPPTAEAGSSTQPHRPKDLLYVLLCANGRIVTLLRPRKHSVHPIDLLLLTNMVMGSRSIKRSGGSEDAEIWLPLSMPKFAPHGFVHAYVKFLDPESWIGSRREGSEMVGDAKMTSSELAVIVVTGDKDAFPTVSAWISSLVAQPPAHWADNTADDAGDAGDAGSIRTTDIMAKRAASKKQAGKSAKPTQTELASWMTHFQRHILTLCRHLTDASNIEQGSPRVSAYTCAELGLAGLRHFVYRSNSTIQLTSPSLPDPYASDAVHRKRLLTLYSLVHHQIHHPLPASASHSESSSSSTTAPPTGMLNGVFGTPASSHPRLSADTRLKMHLVKSHHEQILGWITSPFELYLCLNPQLSKSAIVAVANSLTKWIKSNENDLFLVNAGSF
The following text describes a protein:
Function:
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.
Subcellular Localization:
Secreted.
Domain:
The FU repeat is required for activation and stabilization of beta-catenin.
Sequence:
MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCPIQRPCPGERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP
The following text describes a protein:
Function:
Plays a role in iron homeostasis under excess nickel conditions.
Subcellular Localization:
Cytoplasm.
Sequence:
MNNTPRYPQRVRNDLRFRELTVLRVERISAGFQRIVLGGEALDGFTSRGFDDHSKLFFPQPDAHFVPPTVTEEGIVWPEGPRPPSRDYTPLYDELRHELAIDFFIHDGGVASGWAMQAQPGDKLTVAGPRGSLVVPEDYAYQLYVCDESGMPALRRRLETLSKLAVKPQVSALVSVRDNACQDYLAHLDGFNIEWLAHDEQAVDARLAQMQIPADDYFIWITGEGKVVKNLSRRFEAEQYDPQRVRAAAYWHAK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEKGKEDAPAQFQLRQQGGSGAAGDRGRISHPGERDRVGSVRICPGITGAELTQPGAGAVQATPDASERLSIEQRHCEKQWGSSSRRGPECPAPAGKDTLAQRHRSKESGKHISTLTRAPEWVSHSLKLLRSDHSTAGLSNLDTENAKESLTGLECGVEQGVKEEELNEPDTVRVTEQSTEPHSAQSTEQHTEPLPVHIKEEEGNDLLRGPCEGSPFVKEEALELDCVHIKVERQTQSTHSDGNRAEFDHSQQGHYTEDCKGEEQLRDQEIRKTDPLDIIVLRPCSVRVERLSLQHNQQQHELPTTSAPPPASKDNEGSTRNPDAVHHSTHCGKSLSRLGDLVPHQLILPEHRLYSCSQCEKRFTQPSDLEIHQRLHAEHRPFSCSQCGKSFPELSDLNRHHRCHTAERPFICSHCGKSFNQLSNLKIHQHFHTGHRPYSCSQCGKSFSQLSDLNRHQRIHTGERPFICSECGKSFSHLSVLKCHQRVHTGERPFTCSQCGKSFSRLSFLKCHQRIHTGERSFICNQCGKSFIDLRGLKRHQRIHTGEKLFICCQCGKSFLDLSSLESHQRTHTGERPYSCSQCGKSFIDLSTLKRHQRIHTGEKPFSCSHCGKSFINSSDLKKHQRIHTGERPFKCTLCGKSFCQSGALKSHHRIHTGEKPFSCTQCGKSFSNSSDLIKHQRIHTGERPFTCSQCAKSFNVLSKLKSHQRVHTGERPFSCSQCEKTFSLLSTLKRHQRIHTGEKPFSCSQCGRSFSDLSNLKRHERIHVGEKQL
The following text describes a protein:
Function:
Attaches the virus to host LDL receptors, inducing clathrin-dependent endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and endosomal membrane.
Miscellaneous:
MISCELLANEOUS: The Ogden glycoprotein is missing the basolateral targeting signal in the cytoplasmic domain, therefore this protein should not be targeted correctly to the neurons dendrites as the other VSV G. Palmitoylation site is also missing on this domain.
Subcellular Localization:
Virion membrane; Single-pass type I membrane protein. Host membrane; Single-pass type I membrane protein.
Sequence:
MLSYLIFALAVSPILGKIEIVFPQHTTGDWKRVPHEYNYCPTSADKNSHGTQTGIPVELTMPKGLTTHQVEGFMCHSALWMTTCDFRWYGPKYITHSIHNEEPTDYQCLEAIKSYKDGVSFNPGFPPQSCGYGTVTDAEAHIVTVTPHSVKVDEYTGEWIDPHFIGGRCKGQICETVHNSTKWFTSSDGESVCSQLFTLVGGIFFSDSEEITSMGLPETGIRSNYFPYISTEGICKMPFCRKQGYKLKNDLWFQIMDPDLDKTVRDLPHIKDCDLSSSIITPGEHATDISLISDVERILDYALCQNTWSKIESGEPITPVDLSYLGPKNPGVGPVFTIINGSLHYFTSKYLRVELESPVIPRMEGKVAGTRIVRQLWDQWFPFGEVEIGPNGVLKTKQGYKFPLHIIGTGEVDSDIKMERVVKHWEHPHIEAAQTFLKKDDTGEVLYYGDTGVSKNPVELVEGWFSGWRSSLMGVLAVIIGFVILMFLIKLIGVLSSLFRPKRRPIYKSDVEMAHFR
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
Subcellular Localization:
Nucleus.
Sequence:
MSSRKQGSQTRGQQSAEEDNFKKPTRSNMQRSKMRGASSGKKTAGPQQKNLEPALPGRWGGRSAENPPSGSVRKTRKNKQKTPGNGDGGSTSEAPQPPRKKRARADPTVESEEAFKNRMEVKVKIPEELKPWLVEDWDLVTRQKQLFQLPAKKNVDAILEEYANCKKSQGNVDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILLAHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLGYLHDFLKYLAKNATSLFTASDYKVASAEYHRKAL
The following text describes a protein:
Function:
Conducts the efflux of threonine.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLMLFLTVAMVHIVALMSPGPDFFFVSQTAVSRSRKEAMMGVLGITCGVMVWAGIALLGLHLIIEKMAWLHTLIMVGGGLYLCWMGYQMLRGALKKEAVSAPAPQVELAKSGRSFLKGLLTNLANPKAIIYFGSVFSLFVGDNVGTTARWGIFALIIVETLAWFTVVASLFALPQMRRGYQRLAKWIDGFAGALFAGFGIHLIISR
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MAPKAAEKKPVATAEKTTAGKKPKAEKRAPATKEAGGEGKTRGRKKGSKAKKGVETYKIYIFKVLKQVHPDIGISSKAMSIMNSFINDIFEKLAGESAKLARYNKKPTITSREIQTSVRLVLPGELAKHAVSEGTKAVTKFTSS
The following text describes a protein:
Function:
Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes; Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus.
Sequence:
MDALSADLALQAILGRGSDFVSGIDNEALDFSQLEDFINSEGSQSTNPYFNESLNSTPPSGKLLNVIVENKRNAGHSLPESPPDSSSEHPYSPQEGCEPLNPSENIYTTLGPNIYKPVIGPMLGDNLILGSHIVVAEQNGIMQDTGLMIPEDSNQNFTDRGIYKGDENLVHLGYTPAIENNLCEPNLDNIQTVYTNLQSAPKKRKLSQDSPLVKSEPENCTTSQLSPPGPLSTPLDEEYASSEACLSESQYQCIRFSPFQQPQWHALCDQSLTELPVPHYRVDADKGFNFSNADDAFVCQKKNHFQITCHVQLLGDAQFVKTPDGFQKISSFHLHFYGVKHDCPTQTIRVEQSQSDRSKKPFHPVLVELVNSQVTKVTVGRLHFSETTSNNMRKKGKPNPEQRYFQLVVGLHAHTTNGNFPVISHASQKIIVRASNPGQFESDVELCWQKGQTQDSIFHNGKVGINTDRPDESLVVHGNIKVTGHIIQPSDIRAKKNIVECDTAEQLRNVQKLRVVRYDYEPSFASQLSRDSQHSDTGVIAQEVAKILPEAVRPAGDLVLKNGQSIDNFLVVNKERIFMENIGAVKELCKVTDNLETRIDQLERINRRLNKLKRGDSLKSTSTVSSLKHSNSMQKCSKHHCDRDDELCSNKFIQIIIVILVLIMAFCLAAITTLYLMEASRHNQFVRTNLQQTHRSSIVTKRQMKVPKNHQSRHTEYHKTSNNNYKDDDVTRITIDPSLTKRPSAIIGRPPDCLSVDQDLESSHLCQIYCCAATQPPVIPPPESPNSIYGDKSTNRTVLNLEQAKLATPFHSTTNEIDKRQKRDAYDLTGEISSFDMPDDQIFLIIVQGRNFNTTLTHKYLIAQPEPHNYSYSVPISKYMPDEFINLIFRSTQESIKEVEYCNNNYKERGCAFEKPQTRHKVNEHSPSQLISTQSVIFEVNMADFQSKIMTYRASSRANQNTCKLSNLDEFIEYNFHFYRHCDE
The following text describes a protein:
Function:
Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, cell cortex. Cell junction. Nucleus. Note=Associated with the cortical actin cytoskeleton structures in terminal web and cell-cell adhesion sites (By similarity). Highly expressed at the ectoplasmic specialization, an actin-rich cell junction specific to the testis (By similarity). Predominantly nuclear in nonconfluent cells.
Sequence:
MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQKK
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate; Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
Miscellaneous:
MISCELLANEOUS: In both reactions the enzyme functions only with beta anomers; MISCELLANEOUS: The function of the domain II is independent from the activity mediated by domain I.
Sequence:
MKVTLPEFERAGVMVVGDVMLDRYWYGPTSRISPEAPVPVVKVNTIEERPGGAANVAMNIASLGANARLVGLTGIDDAARALSKSLADVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFEGVDPQPLHERINQALSSIGALVLSDYAKGALASVQQMIQLARKAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVVGKCKTEEEIVERGMKLIADYELSALLVTRSEQGMSLLQPGKAPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNSLEEACFFANAAAGVVVGKLGTSTVSPIELENAVRGRADTGFGVMTEEELKLAVAAARKRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGDSRPVNPLEQRMIVLGALEAVDWVVSFEEDTPQRLIAGILPDLLVKGGDYKPEEIAGSKEVWANGGEVLVLNFEDGCSTTNIIKKIQQDKKG
The following text describes a protein:
Function:
Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation. Promotes also the degradation of other substrates such as CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus, nucleolus.
Sequence:
MDQQPSPRSCSRGAAACDVVANEPSMNLYIHTTTGTRYELSVPAEETVEGLKRRLSQRLKVPKERLALLYKETRLSSGKLQDFGVTEGSKLTLVPTVEAGLMSQASRPEQSVMQALESLTETQVNDFLSGRSPLTLALRVGDHMMFVQLQLAAQQAGGGLQHRHHSASRGEPGAATGNPSAQCRPLHGTTGATAASSPSANFNARVPAANPAPVTAAGMFRSHGASTQTVNSSLLSSCPEVDCSSRGGNPSPSTSASSPHSGSPTPASRSRKPGAVIESFVNHAPGVFSGTFSGTLHPNCQDSSGRPRRDIGTVLQILNDLLSATRHYQGMPQSLAQLRCQTRCPPAASATATSATTATSATTTSSSSSSSSSSSPLPSPDTTTKTATSCEKLPLHPTAVVQCQSQIRMCKPAGDRLRQTENRATRCKVERLQLLMQQKRLRRKARRDARSPYPWLPHRKSSRANSNSSVSSDGSLDLDFEDSLWKPEVKADLKSEFVVA
The following text describes a protein:
Function:
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDPTLKLLTLINVSAARPGKRQRSSNLTHYDKITRKAAAAQQATASTSTVVATSATSPSKRSKVAMVSDGSTSSPANAQDGAELVGEDSDEDEEDAATASSFSSSKQQKQKQSTAFDAHFGSDGPHAQIVSKLPESVTSLTWSTSRSTLPALATQIATSTPSIPDFDARQYRGQPQVKVLEAFNAFTAKKYTAPTPLHKALATTLASYADFCDANVALNDRPQYRQVLAMHAMSHIAKTRRRVLKNNEKLAKLAAANSASTDSDDLDLRDQGFTRPKVLILLPFRNSALEWVDLLTKFSLCSQVDNKSRFSKEYDLPEGAVDKLADPAVAAKYPQDHIANFAGNIDDSFKLGLKVTRKSLKLFSGFYDSDVIVASPLGLRLGIEKDKGDSDFLSSIEMLIVDQTDVISMQNWEHLEFVMERLNQIPRQSRDTDFSRVKQFYLDNRAAMFRQTVLLSAYDFPSLRSVYNHKLNNIAGKIRTIASTSETQAEMSRVVSGVRHMFSRFEAANPHAEPDLRFAHFTNKTLQQLSKSAIASSHTLIVVPSYFDFVRLDAFLREHNEKRKPGQTANLSYTSISEYSSPKDIRRARESFFSAKKRFLLLTERAHFYRRFKLRGVQTVVFYQLPQNARFFSEVLEFPFVTKADLAKGRGDAHDDEQEIDPNQVSTYVVYSKYDLMALEKVVGSEQAKQMVVADKATWKFV
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQVASFTALGFRGTADFVIACFDVNDVIVSAIFFVTSTPFKFKHFVQIVENFDRIDARISPILVEQIRKRSNIFVKVLVTFLPTLYVLDLFMWGKNNWEGLNNYFAFYIMYSIVVVHELQYWHIMTMMYARILGLNKTLRDYFKNKTGFCEHEILVVTQSFNSINDSVEEINKCFSYSTTTIIFSCYIHLVISPYQLFVVVSSTETSLFNYVYLLWISLHIMRVLTIVEVCQKCENENRKTRSLVYQLLLCKLNEKVKNMVRVLFFLVTTRKILFSAYALPKINRRLIISILSSISTYWMILMQSTSRTIQVV
The following text describes a protein:
Function:
Has growth inhibitory activity.
Subcellular Localization:
Secreted.
Sequence:
MPLTGVGPGSCRRQIIRALCLLLLLLHPSSAKNIWKRALPARLAEKSRAEEAGAPGGPRQPRADRCPPPPRTLPPGACQAARCQADSECPRHRRCCYNGCAYACLEAVPPPPVLDWLVQPKPRWLGGNGWLLDGPEEVLQAEACSTTEDGAEPLLCPSGYECHILSPGDVAEGIPNRGQCVKQRRQADGRILRHKLYKEYPEGDSKNVAEPGRGQQRHFQ