lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.
Subcellular Localization:
Nucleus.
Sequence:
MGDREAVLLEALSRCGLRGLSQAWVDSVWELDFTETEPLDSRIEAEITENGLETFSSLHENLLAFASEDPENSRSVWLLFSENDICRNSLVALLSHFIQAAANKKANAIQRILALNAAGLYFLLLEIPGSVANQVFHPVLFDKSVNALEKCWPRDPNASRKRKKDTLKSSQGDNRGGRKRPRPPRRDEQEMEDLSEEEQDEEEVYFSTRDLMHIRDSIFLVLKNFLRLLPKFSLKEKPQSVLHCIQIFINLTSFESVPQEMPFSDAVSVNHMKYVPELAYHGLWLLCLPIHGEGNQTVRRLFQRLLSVILMMKGGEGSNSALLVISPPVISARNQAIRFISFLVNELKEGTIPVLNILLQHICVKFPDKADYRVYAAQALVKLMENLPNAEYAIFIEWLYKYSKNSKISYRVFALEVVVALLDLPEREADVSLPHENLNFLQHKFLLQHMVFSRCSDKAPTVRSKALSCLAQCLEKNSTTAIDGVQELLQGSSCRTVFGTNITETTGNGTVYASNANEATTHPQKTMATLKIIEVSDTGDTLSSDGKEVLTMLRYRAGDEKTNVRKSALQVLVNVLKCHLIPCSSEDLSTLQDRCRDPAVSVRKQALTSLTELLLAQPHSVLIQKAWLTGLIPVVLDTESSVQEKALECLDQLLLQSITHYKRFKQDDERQKLTWDLLTLLTSESQDLSRYLTKAFHLWSKQDKFSSTFITNLISHTETEHTAPAWMILSKVAGSSPKLDYTKILQSWERVSRQTDADINTTGHILCVIGHIAKHLPADTRTHLIDHVKSWLKEFKSSPEVISPAVEALQKLCHAQTDKPEDVQDLLNDVCGEIVSACEHHISSVVMADCKDEPLDQDLLVKHLFTLGEVAQLCPAKVEKRVLLLVQSILASSVTTEQNSCHSDAEDPPVSQPLSQFKGSNMPSLIRAHAFITLGKLCLQHEDLAKKCIPALARELEVCDDVAIRNNVIIVICDLCIRYTTMVDRYIPNVSVCLRDRDPFIRKQTLIMLTNLLQEEFVKWKGSLFFRFVSVLVDPDPEIAKFGEFCLVHLLLKRNPVMFSQHFIECIFHFNCYEKHEKYNKFAQTKRERTLFSLKGKENKDKRMKIYKFLLEHFTDEQRFNLTTKISHNVLACFVDGILPIDMEANELLSDIFDIMSSKEIKLSAMRSKPGEDVGADDDEMAMANAVMQAAQKKLISQVQKKNFVENIIPIITSLKGFLEQHRIPAVRDLMNYLREMMQDYRDEIKDFFAADKQLAAELEYDMKKYEEQLEREQEENVQNPPSAESTGSPKGSPRAVNAISSPRSPNAPKSPLSTNAQTPGGAAPCTPITTPRVSILKGQGPRPRQMSLSTLAILNSARKAAQDNKKQRSKSIGAQPSTPSPARTTSSKQVTFRSEDQQSDSSLVGRMISTPDVTIENVTFGAGVSYISASQTPLSGRRGSIGSHEKERDVLCIMSPDKPAPQPRKWNVESPVQRRSIRQRISGKAPLKPSN
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MVWDVHHGQALVWVVTATLQTTIALSTTEAKYMAITEAFKKAIWLKGLFGELSKNLQITMVFCDSQSAIFVTKDQMFHERTKHIDVRYHFVREIIVHDIVASKISIHDNPTDMMTKTLPSVKFEHCFDLNLLMTTESALLYLDLPSNILMADDVQLLTNAAKKFLAAHFMGHNQAQLELARGSGAQNGDEPDFNTMSRKDLGPNSTSEASSKSYDIALKWARKHYPKLEERWEVWSSHLCHLIRFPFMTERKLRKVIMCNDFDPKLASKRVIEALFYKDEAPYWQRSIATKAGNALHHCYVQRASKYRPVKALPFEMPRQQCIIYLDLKRDECARLFPAGKVYSQASHLGGRVFPISMLQHGSTKWIQLLWVVSGYAREGGSHLQLITSLQLVSVQTRNILTKSLEVILHEHAFKSLVHQHTGSLYNASVPSSLAGMELSLVRLRSRTLWEKGANFSGFSIPPRTILVPYVKRIHIVYNDLGNLSSHYFNLSGYNLLTSVIGFIVYDAPSHISTILSLRKLDLDQRNNLYQLSSRI
The following text describes a protein:
Function:
Forms the portal vertex of the capsid. This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection (Probable). The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel. Binds to the terminase subunits to form the packaging machine.
Subcellular Localization:
Virion.
Sequence:
MKTPTIPTLLGPDGMTSLREYAGYHGGGSGFGGQLRSWNPPSESVDAALLPNFTRGNARADDLVRNNGYAANAIQLHQDHIVGSFFRLSHRPSWRYLGIGEEEARAFSREVEAAWKEFAEDDCCCIDVERKRTFTMMIREGVAMHAFNGELFVQATWDTSSSRLFRTQFRMVSPKRISNPNNTGDSRNCRAGVQINDSGAALGYYVSEDGYPGWMPQKWTWIPRELPGGRASFIHVFEPVEDGQTRGANVFYSVMEQMKMLDTLQNTQLQSAIVKAMYAATIESELDTQSAMDFILGANSQEQRERLTGWIGEIAAYYAAAPVRLGGAKVPHLMPGDSLNLQTAQDTDNGYSVFEQSLLRYIAAGLGVSYEQLSRNYAQMSYSTARASANESWAYFMGRRKFVASRQASQMFLCWLEEAIVRRVVTLPSKARFSFQEARSAWGNCDWIGSGRMAIDGLKEVQEAVMLIEAGLSTYEKECAKRGDDYQEIFAQQVRETMERRAAGLKPPAWAAAAFESGLRQSTEEEKSDSRAA
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
Sequence:
MKHGILVAYKPKGPTSHDVVDEVRKKLKTRKVGHGGTLDPFACGVLIIGVNQGTRILEFYKDLKKVYWVKMRLGLITETFDITGEVVEERECNVTEEEIREAIFSFVGEYDQVPPAYSAKKYKGERLYKLAREGKIINLPPKRVKIFKIWDVNIEGRDVSFRVEVSPGTYIRSLCMDIGYKLGCGATAVELVRESVGPHTIEESLNVFEAAPEEIENRIIPLEKCLEWLPRVVVHQESTKMILNGSQIHLEMLKEWDGFKKGEVVRVFNEEGRLLALAEAERNSSFLETLRKHERNERVLTLRKVFNTR
The following text describes a protein:
Function:
Inhibits papain and ficin (cysteine proteinases) but not trypsin (a serine proteinase).
Subcellular Localization:
Cytoplasm. Vacuole.
Sequence:
MKLGVRLCVLVVFSLQLWGPGQGQELEPEQVLAFCDDKDVEAAVDLALVKYNQKLPYGNQLALYQILESSKAQNDSCTQYFVEFNSRVTDCPAGGDKVWRDCDYLPTGNKVPRPCKATVHMSETDKKVLAVFCDPVEAPVVAERTTCLGCPREIDVESEDLKDPLTYSITRFNADSDSSHHFILNSVGFATRQVVAGFRYRLMFDMRKSNCSKADHKELNDECHPDPDVELAHCNSTVDVAPWRHETAEANVECAPGPLDNFDVFRRRPPGWSPLRNFNNFAEVKTTQASTASAKEESSEESQERSPSAVTMANPEPALPSVAPTTAAESPFHCPSKPWKQFVPPTTLRPAQEKSPTPLPVVEEGLSDLDLLGKK
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MNAILEKYTFKDDYVSPRGIPKVAFVENVAELVKSSGDSAETLLKRFSEQYSKYKLAEHRLIRTTANLEAKIPDIKKTLQTLEYLKKSLVAENGGRGFTTNYGLTESVFCQAKVLPQKTVHLWLGANVMVEYTFEEATQLLERNLKSATENLAATQEDLAWLQEQQTILEVNTSRLYNYDVVERRNKSEEEAKK
The following text describes a protein:
Function:
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Sequence:
MSLAPRERILVALDTPDLDAAVALATRLRGQVGGYKVGLEICSAVGVPQIVSAMTAVGGSVFLDLKLHDIPNTVAGAVRAVCNLGPAVQMLTLHCSGGSAMLRAAVNAAQSMPYRPLLLGVTVLTSLDATALAGELRVTSDITDYVVHLARMAQDCGLDGVVASPHEVSAIRTACPHVRIVTPGIRPQWAAEGDQRRVMTPAAALRAGADYLVIGRPITAPPAIIGDPVTAVARILAELEQE
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNLEPINNALSQLRVLRSSVGQVFETLGTGVRADHGEEGKEQKFLQELQELLNSVNANLKDFESCINDLTPPQTPLTLANSAYLSLETNLERQALYPHLVQSYKWHDKLHEYSTFASTLLQQNSLKRSYYTNTKRRRSLPSSHLATPQMVENLIGSIHYNNMNLKIARPFMTNAILHITIARVLRAAVILKGLLIEWVTVKGYEESLLDGVDEQWTESRHQVFRKVQDHAHSAMLHFFSPTLPELAIRSFITWFRSYVTLFADPCKKCGKHLHNTLPPTWRDLRTLEPFHEECKQ
The following text describes a protein:
Function:
Has a role in establishing the characteristic rod cell shape. Important for cell polarity and is involved in directing growth to the cell ends.
Subcellular Localization:
Cytoplasm. Note=Localized to the cell tips except during mitosis.
Sequence:
MEYRTNNVPVGNETKSAALNALPKIKISDSPNRHHNLVDAFMQSPSYSTQPKSAVEPLGLSFSPGYISPSSQSPHHGPVRSPSSRKPLPASPSRTRDHSLRVPVSGHSYSADEKPRERRKVIGNYVLGKTIGAGSMGKVKVAHHLKTGEQFAIKIVTRLHPDITKAKAAASAEATKAAQSEKNKEIRTVREAALSTLLRHPYICEARDVYITNSHYYMVFEFVDGGQMLDYIISHGKLKEKQARKFVRQIGSALSYLHQNSVVHRDLKIENILISKTGDIKIIDFGLSNLYRRQSRLRTFCGSLYFAAPELLNAQPYIGPEVDVWSFGIVLYVLVCGKVPFDDQNMSALHAKIKKGTVEYPSYLSSDCKGLLSRMLVTDPLKRATLEEVLNHPWMIRNYEGPPASFAPERSPITLPLDPEIIREMNGFDFGPPEKIVRELTKVISSEAYQSLAKTGFYSGPNSADKKKSFFEFRIRHAAHDIENPILPSLSMNTDIYDAFHPLISIYYLVSERRVYEKGGNWNRIAKTPVSSVPSSPVQPTSYNRTLPPMPEVVAYKGDEESPRVSRNTSLARRKPLPDTESHSPSPSATSSIKKNPSSIFRRFSSRRKQNKSSTSTLQISAPLETSQSPPTPRTKPSHKPPVSYKNKLVTQSAIGRSTSVREGRYAGISSQMDSLNMDSTGPSASNMANAPPSVRNNRVLNPRGASLGHGRMSTSTTNRQKQILNETMGNPVDKNSTSPSKSTDKLDPIKPVFLKGLFSVSTTSTKSTESIQRDLIRVMGMLDIEYKEIKGGYACLYKPQGIRTPTKSTSVHTRRKPSYGSNSTTDSYGSVPDTVPLDDNGESPASNLAFEIYIVKVPILSLRGVSFHRISGNSWQYKTLASRILNELKL
The following text describes a protein:
Function:
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
Miscellaneous:
MISCELLANEOUS: Present with 5710 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. At anaphase, the MCD1 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
Domain:
The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable MCD1 protein, forming a ring structure.
Sequence:
MGRLVGLELSNFKSYRGVTKVGFGESNFTSIIGPNGSGKSNMMDAISFVLGVRSNHLRSNILKDLIYRGVLNDENSDDYDNEGAASSNPQSAYVKAFYQKGNKLVELMRIISRNGDTSYKIDGKTVSYKDYSIFLENENILIKAKNFLVFQGDVEQIAAQSPVELSRMFEEVSGSIQYKKEYEELKEKIEKLSKSATESIKNRRRIHGELKTYKEGINKNEEYRKQLDKKNELQKFQALWQLYHLEQQKEELTDKLSALNSEISSLKGKINNEMKSLQRSKSSFVKESAVISKQKSKLDYIFKDKEKLVSDLRLIKVPQQAAGKRISHIEKRIESLQKDLQRQKTYVERFETQLKVVTRSKEAFEEEIKQSARNYDKFKLNENDLKTYNCLHEKYLTEGGSILEEKIAVLNNDKREIQEELERFNKRADISKRRITEELSITGEKLDTQLNDLRVSLNEKNALHTERLHELKKLQSDIESANNQEYDLNFKLRETLVKIDDLSANQRETMKERKLRENIAMLKRFFPGVKGLVHDLCHPKKEKYGLAVSTILGKNFDSVIVENLTVAQECIAFLKKQRAGTASFIPLDTIETELPTLSLPDSQDYILSINAIDYEPEYEKAMQYVCGDSIICNTLNIAKDLKWKKGIRGKLVTIEGALIHKAGLMTGGISGDANNRWDKEEYQSLMSLKDKLLIQIDELSNGQRSNSIRAREVENSVSLLNSDIANLRTQVTQQKRSLDENRLEIKYHNDLIEKEIQPKITELKKKLDDLENTKDNLVKEKEALQNNIFKEFTSKIGFTIKEYENHSGELMRQQSKELQQLQKQILTVENKLQFETDRLSTTQRRYEKAQKDLENAQVEMKSLEEQEYAIEMKIGSIESKLEEHKNHLDELQKKFVTKQSELNSSEDILEDMNSNLQVLKRERDGIKEDIEKFDLERVTALKNCKISNINIPISSETTIDDLPISSTDNEAITISNSIDINYKGLPKKYKENNTDSARKELEQKIHEVEEILNELQPNARALERYDEAEGRFEVINNETEQLKAEEKKILNQFLKIKKKRKELFEKTFDYVSDHLDAIYRELTKNPNSNVELAGGNASLTIEDEDEPFNAGIKYHATPPLKRFKDMEYLSGGEKTVAALALLFAINSYQPSPFFVLDEVDAALDITNVQRIAAYIRRHRNPDLQFIVISLKNTMFEKSDALVGVYRQQQENSSKIITLDLSNYAE
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTDRLTQLQQCLDQIVEQFGSAITYVDRNHDFEPHNELEDKLSDPQATIAAAEDFDRNIDELTTDMILKTRQIIKLIDSLPGVDVSAEEQLSRIDSLQKKLIQVEGEKIEAIKRKESLTKDIEELINEFTEGIANSRRLNKA
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin Rv0909. Does not exert its toxic effect via translation.
Sequence:
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLNGDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG
The following text describes a protein:
Function:
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm.
Sequence:
HRIRITLASRNVKSWEQVRADLIRGTKEKNLRIKGRAPMPAKTLRITTRRTPCGEGSKTWGRFQTRIHRRRMDLPSPSEAVEQIPSVRTEPGVEAEVTIADA
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.
Miscellaneous:
MISCELLANEOUS: Present with 5550 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSEILQDVQRKLVFPIDFPSQRKTEKFQQLSLMIGALVACILGFAQQSLKVLLTAYGISCVITLICVLPAYPWYNKQKLRWAQPKIEINVDQYD
The following text describes a protein:
Function:
Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes. Recruited to the promoter of ICS1 and other defense-related genes (e.g. PR1 and SID2) in response to both biotic (e.g. Pseudomonas syringae pv. maculicola ES4326) and abiotic stresses (e.g. UV-B), thus triggering slow defense responses by stimulating salicylic acid (SA) biosynthesis. Required for basal and systemic acquired resistance to P.syringae pv. maculicola and Hyaloperonospora arabidopsidis.
Subcellular Localization:
Nucleus.
Sequence:
MAGKRLFQDLDSDQENKSEKRIKSVLPSLASPISSVFGALISENTLRSVLEPVIRKVVRQEVEYGISKRFRLSRSSSFRIEAPEATTPTLKLIFRKNLMTPIFTGSKISDVDNNPLEIILVDDSNKPVNLNRPIKLDIVALHGDFPSGDKWTSDEFESNIIKERDGKRPLLAGEVSVTVRNGVATIGEIVFTDNSSWIRSRKFRIGAKVAKGSSGQGVVVCEAMTEAIVVRDHRGELYKKHHPPMLEDEVWRLEKIGKDGAFHKKLSSRHINTVQDFLKLSVVDVDELRQILGPGMSDRKWEVTLKHARECILGNKLYISRGPNFFMILNPICEVMKALIDGHVLSSQESLNQPYVKNLVRDAYSKGNFLEVGERTANEAALLTQGDDLDQQYAASHYQNIEIDKSYQQNGYVQERSTNNLEIVNEGYITTPAEFNICFTGSSSQNHINPF
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Sequence:
MAGATQPAPLAPVALDQPMSNPSKILFQQETELPAETSGGPNTDANVASPSPKTLDGASQAPNVEAPPPESSSREGPSGSPPKRRKLDEPCGFCNEQTAKYRCPGCGVQTCSLECSKGHKERTGCKGQRNKTAMVKMAEFDENNLISDYNFLEEALRQNEASRRMRGTFEGGPYSRTPGKLMALITQARNRRIELILLSSDLSRRKANTSYYDKKRKCFFWRIEWVFPSAQVQLATTKLDEHQPPLKALGGLLEARPGNAALRHKLRDYCAAGADTLTFLLRKDCCKASEQVYYKIDPSRPLRKLLERKTLIEFPVITVALPSEAGSYTLEEEEPESSESAWGASSEKGWQSDGNIAALVDPRVQLYAEKPAEGGGEVGADREEGNGPPEEVPIVRGRDGAEVGGGKGGGEGGGDEDVPDVELAALLAKAAMADFNRKRKKMEEDAREARA
The following text describes a protein:
Function:
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
Sequence:
MNKEQKSKFVHEVFENIHTQYDRANNKISFGLQKNWKQELVDKIVEETPKNSDFLDVCCGTGDISIWLAKKREDLNIIGVDFSSAMLNEAVKKSKNLNIVWKEADALCLPFKDSSFSAVAISFGLRNTVDYEKVLKEMIRVVKKDGFIYCLDSFVPDCLWIQPFYKMYFKYIMPLFGGGKKYYKEYVWLYESTQQFLKKKELILLYEKLGLKEIKHCSKMFGVCVMIQGKK
The following text describes a protein:
Function:
Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. Negatively regulates the biosynthesis of acetyl-CoA from pyruvate in the mitochondrion.
Sequence:
MSATIPPGSPSGDILQPICADQVPLSQSQTFGQQQKPKTQGNRTNKPSNLKTRSKMSLSSKKTITDLPAGEIKGKRVLIRVDFNVPQDKTSGQITNNARIVAALPTIKYVIENGSKAVILCSHLGRPNGAPNAKYTLRPVAEELQKVLGKDVTFIDECVGPKVEETVAGCKEGQVFLLENLRFHLEEEGSKKDEETGEKTKASAEAVEGFRASLTKLADLYINDAFGTAHRAHSSVVGFKGEPRLAGFLMKKELEFFSKVLEKPEPPFLAILGGAKISDKIQLIENLLDKVNKLIVCGGMAFTFKKMLDSVEIGNSLFDEDGSKKVHDLVAKAKKNNVELIFPIDYICGDKFAKDAARKTVTDAEGVPKGWMGLDAGPASREEFKKAILSSKTILWNGPAGVFEFDNFAEGSKAMLDACIEACQKGATVIVGGGDTATVCKKYGAEDKLSHVSTGGGASLELLEGKNLPGVANLSEKK
The following text describes a protein:
Function:
May play a role in neuronal cell development.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDDARDTIANGVGEDAAEMPNSDSPAEDAAEVQCGPATTSNEPAPDDHMEEQPEITAMCAESTPPGILDQSKASAADETPLNGEVTEDTLVECVDSVSLEGDTGSEIPLKEQDDAAVDPSSQAGRWAGWGSWGKSLLSSASATVGHGLTAVKEKAGATLRIHSANSASPEGAPTDAENGISGNVTPDQDPARGPHTPPPPGAAGSRGMLSALTNVVQNTGKSVLTGGLDALEFIGKKTMIVLAESDPGFKRTKTLMERTVSLSQMLREAKEKEKQRLAQQLTVERTAHYGMLFDEYQGLSHLEALEILSNESESKVQSFLTSLDGEKLELLKNDLISIKDIFVAKESENEANPEEQGLEESGEEFARMLTELLFELHVAATPDKLNKAMKKAHDWVEEDQSVVSIDVAKGSEEEEKEEGKEEKAEEPEEDKTGGQGAKTVEEVYMLSIESLAEVTARCIEQLHKVAELILHGQEEEKPAQDQARVLIKLTTAMCNEVTSLSKKFTNSLTTVGSNKKAEVLNPMINSVFLEGSNSTTYVQDALQLLLPVLQVSHIRTSCLKATAQPDCS
The following text describes a protein:
Function:
Essential for the beta oxidation of unsaturated fatty acids.
Subcellular Localization:
Peroxisome. Note=This location is DCI1 dependent.
Sequence:
MSQEIRQNEKISYRIEGPFFIIHLMNPDNLNALEGEDYIYLGELLELADRNRDVYFTIIQSSGRFFSSGADFKGIAKAQGDDTNKYPSETSKWVSNFVARNVYVTDAFIKHSKVLICCLNGPAIGLSAALVALCDIVYSINDKVYLLYPFANLGLITEGGTTVSLPLKFGTNTTYECLMFNKPFKYDIMCENGFISKNFNMPSSNAEAFNAKVLEELREKVKGLYLPSCLGMKKLLKSNHIDAFNKANSVEVNESLKYWVDGEPLKRFRQLGSKQRKHRL
The following text describes a protein:
Function:
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
Subcellular Localization:
Cytoplasm.
Sequence:
MEKKRMVIESIYLRNFRNFSDFKTNFKDGINVIYGPNGSGKTSILEAVAYLSNPRSFRGARDHQLIKLGEKFFEINGKILSGNESHEITISYHHDEIKKEKIAYLDGFKVKRFRDIQEIFIAIPFSFKDYAMIDGYATQRRDFFDDIFSLLDLEYYEILRNYEKLLDERNDLLKEENIDRDYVIYLAKEMQPLAEKIVEKRETMIKELSKYLDPMFKVEYISEFKGKNIVDYIEEDIARGITTVGPHVHDDYTFYYKGNPAKYFASEGQKRLLYLSLVLAFRKLIEETKLYEPVFLFDDPVNVLDPHLLEKFISHLSGQVIIASLSPLLGAYNIGLTLEG
The following text describes a protein:
Function:
Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MGPERRGAAALLALLCVACALRAGRAQYERYSFRSFPRDELMPLESAYRHALDKYSGEHWAESVGYLEISLRLHRLLRDSEAFCHRNCSAAPQPEPAAGLASYPELRLFGGLLRRAHCLKRCKQGLPAFRQSQPSREVLADFQRREPYKFLQFAYFKANNLPKAIAAAHTFLLKHPDDEMMKRNMAYYKSLPGAEDYIKDLETKSYESLFIRAVRAYNGENWRTSITDMELALPDFFKAFYECLAACEGSREIKDFKDFYLSIADHYVEVLECKIQCEENLTPVIGGYPVEKFVATMYHYLQFAYYKLNDLKNAAPCAVSYLLFDQNDKVMQQNLVYYQYHRDTWGLSDEHFQPRPEAVQFFNVTTLQKELYDFAKENIMDDDEVSFHLLELEESCELALV
The following text describes a protein:
Function:
Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
Subcellular Localization:
Cell membrane. Secreted.
Sequence:
MKVLKYIPLLLWYLIWDYLDLVPLVLGHSEQSHPGTKVGIAVTGGKERHPLPKVNATRTGILGHGLQKGRTKVPLVQSRIFLSKNEDIKKQAGNRAIPHAKNGNVENRQSGVKIGTPRPPHVTSKASTKLINIHADSAGFKPKRPLNPLTEKEQKDIFKHQLITPHEYMLSLYRTLSDVERKGINGSLKLEAGLANTITSFVDKGQDERMAAARKQKYVFDISALEKDGLLGAELRILRKRPTDTKFNIAGKLSQIKLYSCPANKKSASLLDSRPLSSIDTPKWEVFDIWKLYKNFKNSAQLCFELEVMDKGKPADLRSVGFNRTGRPTNEKAIFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFNQRRKRRAPLSTRQGKRPNKNSKARCSKKPLHVNFKDMGWDDWIIAPLEYEAYHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPETTPPTCCVPTRLSPISILYTDSANNVVYKQYEDMVVESCGCR
The following text describes a protein:
Function:
Involved in anthocyanin and protoanthocyanidin biosynthesis by catalyzing the oxidation of leucoanthocyanidins into anthocyanidins.
Sequence:
MTDVELRVEALSLSGVSAIPPEYVRPEEERADLGDALELARAASDDDATARIPVVDISAFDNDGDGRHACVEAVRAAAEEWGVIHIAGHGLPGDVLGRLRAAGEAFFALPIAEKEAYANDPAAGRLQGYGSKLAANASGKREWEDYLFHLVHPDHLADHSLWPANPPEYVPVSRDFGGRVRTLASKLLAILSLGLGLPEETLERRLRGHELAGVDDDLLLQLKINYYPRCPRPDLAVGVEAHTDVSALSFILHNGVPGLQVHHAGSWVTARPEPGTIVVHVGDALEILTNGRYTSVLHRGLVSRDAVRLSWVVFCEPPPESVLLQPVPELLADGADKPLFAPRTFKQHVQRKLFEKLKDQQDNNAAAASNGMRTK
The following text describes a protein:
Function:
Polyglutamylase which preferentially modifies tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction. By controlling tubulin glutamylation, regulates ciliary specialization and motor-based transport. Promotes the formation of A and B tubule singlets by splaying microtubule doublets in cilia. Together with ttll-4 and 5, required for male mating; [Isoform a]: Specifically promotes tubulin glutamylation in a subset of ciliated neurons including amphid, phasmid, CEP and RnA neurons; [Isoform b]: Specifically promotes tubulin glutamylation in male ciliated CEM, HOB and RnB neurons that release bioactive extracellular vesicles. Regulates the localization of TRP channel pdk-2 in male CEM, HOB and RnB neurons. Regulates the environmental release of bioactive extracellular vesicles in cilia.
Subcellular Localization:
Cell projection, axon. Perikaryon. Cell projection, dendrite. Cell projection, cilium. Extracellular vesicle.
Sequence:
MGCKISTEFCSDNPVGSISTSKVHPTDLSTPSYAIKPVEFYEEPLKDDQLFYKVALAKKEYREKEKDKKEQLSSNRRVSLQVEPNKLPIPLTRSSSLSSIMENRPPSGISNSSFIRSRNTASRRFTIDTSRAKSNQYVVSLCSKKIGIIEYPDGRSDKQPCDVYWHNVVLSDMNKIVTSPQSRVNKFPGMTELAKKISLTHSISSMQKLFPDEYAFYPNSWFLPAHLADFHAFYRKAQALGKTEMWFIVKPDEGAQGTGIYLINSPNQIRNVDQRQLVQEYVADPLLMNDKLKFDFRVYGVIKSINPLSIYVAREGMARFCTEKYEKPDSSNFKNLYAHLTNYSLNKANEAYVHSNTLQDQTRGSKRLLSTVFHQLESRGVKTKRLWHDIKLILVKTTLAMLPEIMLHYEHHFYDSTGPQCFQIMGFDVMIREDGTPILLEVNAAPSLTADHIVPHPGRTLLEGGQRVRSIVDEVIKIPLVRDTLLLVLGLMEEEYQNNSLKGETKSLDDMQTIKQRRKPHLSEIFPTRYGAHSGHLLFLDKAMYIYMQFVQLRSNVNITNAGLKQFVRKCNLIDIIPVVHVDAKVSEINYYFTGEKRTNGNGLPFHAFLMFLFFIAEKKFVLENDLLSKVQRLLSFCDMSLRRYGVRSARLRRAEVDSTIGNVEIYMLPSRMARNRSGTNGRKQNFTDDNNNPNSFAHLPKINERL
The following text describes a protein:
Function:
Possible role in granule neuron development.
Subcellular Localization:
Cytoplasm. Membrane; Single-pass type II membrane protein.
Sequence:
MVVLGRTAKIVLSSGALLLVLWVTLLVFSASSIEESSSPAQPLKDVKQPYITKKKKKVQEKEPDTPWRRVNLKELVIPESAKEAAKNITPAILHLSVRQIDTFSLVVTPPEIKSNLTFLFLHGAAFKSQDWADLGTLGLLGALGYKSVAIDLPGFGKTTTALDGIRDNYVSKVDYATTLVKELQLQKKHIILVSPSMSGNYALPYILTHPEMMAGFVVISPAASGIVPPSKVRALQVPTILIYGDRDTSLGPTSHRDLKTIPNFQAFILPKAGHAAYLDQPDQFHALLYNFAKKIDSFPW
The following text describes a protein:
Function:
Catalyzes the reversible phosphorylation of UMP to UDP.
Subcellular Localization:
Cytoplasm.
Sequence:
MRIVFDIGGSVLVPEDPDIDFIKAIAYELVKISEDHEVAVVVGGGKVARKYIQAAKEFTLNETFKDYIGIHITRANAMLLIAALGEKAYPFVVQDFRKAWEVIQLKKIPIMGGTHPGHTTDAVAALLAEYLQADLLVVVTNVDGVYDSDPKKNPNAKKLDRITVDQLVEIAMQEESKAGGSGVVDALAAKFIQRGKIKTYIVGKKDAYHLFDVIKGKHSGTVVEP
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome; Forms part of the polypeptide exit tunnel.
Sequence:
MEVNVYNIKGEDTGRKVTLNESIFGIEPNDHAIYLDVKQFMANQRQGTHKSKERSEISGSTRKIGRQKGGGGARRGDMNSPVLVGGARVFGPKPRDYFFKLNKKVKTLARKSALSYKVQNNALIVVEDFVFEAPKTKDFVAMTKNLKVSDKKLLVILPEANKNVYLSARNIEGANVQTVSGLNTYRVLNAGVVVLTENSLKAIDNILI
The following text describes a protein:
Function:
Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 1 and 3, to the specific packaging sequence on the left end of viral genomic DNA and plays an active role in packaging of the viral genome into preformed capsids. Specifically binds to the 5'-TTTG-3' nucleotides of the repeats making up the packaging sequence. Forms a transcription factor called DEF-A through cooperative binding with packaging protein 1 (Probable). DEF-A binds to downstream elements of the major late promoter (MLP) and stimulates transcription from the MLP after initiation of viral DNA replication. Simultaneously suppresses early gene expression and is thus likely to participate in the early-late switch in the expression pattern of the late viral proteins. May as well enhance transcription from IVa2 and pIX promoters.
Miscellaneous:
MISCELLANEOUS: All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. Expression of packaging protein 2 and splicing factor is controlled by a L4 promoter distinct from the major late promoter; MISCELLANEOUS: [Isoform Packaging protein 2]: Unspliced isoform.
Subcellular Localization:
Host nucleus.
Sequence:
MAPKKKLQLPPPPTDEEEYWDSQAEEVLDEEEEDMMEDWESLDEEASEVEEVSDETPSPSVAFPSPAPQKSATGSSMATTSAPQAPPALPVRRPNRRWDTTGTRAGKSKQPPPLAQEQQQRQGYRSWRGHKNAIVACLQDCGGNISFARRFLLYHHGVAFPRNILHYYRHLYSPYCTGGSGSGSNSSGHTEAKATG