lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in female and male fertility. Involved in distal reproductive tract development.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MCHVIVTCRSMLWTLLSIVVAFAELVAFMSADWLIGKAKTRSGSGDEQAGMNSEPHYLGILCIRTPAMQQVSRDTLCGTYAKSFGEIASGFWQATAIFLAVGIFILCVVALVSVFTMCVQSIMRKSIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAIDCGRYASPYKPGDCSLGWAFYTATGGTVLTFICAVFSAQAEIATSSDKVQEEIEEGKNLVCLL
The following text describes a protein:
Function:
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
Subcellular Localization:
Cell junction. Cell membrane; Peripheral membrane protein.
Sequence:
MANVCEPLTLAKDVKRSIELLEKLQMSGEVPATKLAALQKVLQSDFLNAVREVYEHVYETVDIQGSLDVRASATAKATIAAFAASEGHAHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVADRHGGLKRGDQLLSVNGVSVEGENHEKAVELLKQAVGSVKLVVRYTPKVLEEMELRFDKQRAARRRQQY
The following text describes a protein:
Function:
Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
DETSGITTITLSSAPANTLSLELLTNLIEKLRDIEKDDSVKGVLVTSKYNGETFISGLNSYDMHNQTDERLAKYWTAVQDIHFTMYSFGKPIVAAINGDAVAGGCAFVLTCDYRVMMKGKRTGLPEAQFGIVAPFFYIDVMKSVIGNRQCELALLEGKIFSTEEAAKVGLVDEAVDLNLVLPNAMKKLQHLVKIPQPAFKLTKQTLRQADIEKFIANRDQNLKTYIQDLTKHSVYVIIRIFFYIVQGFQN
The following text describes a protein:
Function:
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid (By similarity). Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG) (By similarity).
Subcellular Localization:
Secreted. Cell membrane; Peripheral membrane protein.
Sequence:
MLRLCFLLSFMCLVKSDTDETCPSFTRLSFHSAVVGTGLSVRLMLYTQRDQTCAQVINSTALGSLNVTKKTTFIIHGFRPTGSPPVWMEELVQSLISVQEMNVVVVDWNRGATTVIYPHASSKTRKVALILKEFIDQMLAKGASLDNIYMIGVSLGAHIAGFVGEMYSGKLGRITGLDPAGPLFNGRPPEDRLDPSDAQFVDVIHSDTDALGYREALGHIDFYPNGGLDQPGCPKTIFGGIKYFKCDHQMSVFLYLASLQNNCSITAYPCDSYRDYRNGKCVSCGAGHIVSCPSLGYYADNWREYLWDRDPPMTKAFFDTAETKPYCIYHYFVDIISWNKSVRRGFITIKLRGEDGNITESKIDHEPSAFQKYHQVSLLARFNRDLDKVAEISLLFSTKSVVGPKYKLRVLRMKLRSLAHPDRPHLCRYDLVLMENVETFFQPILCSKQQM
The following text describes a protein:
Function:
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTVRVAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRQERDQLFVGDDAIRVLHERSLQSLPWRELGVDVVLDCTGVYGSREHGEAHIAAGAKKVLFSHPGSNDLDATVVYGVNQDQLRAEHRIVSNASCTTNCIIPVIKLLDDAYGIESGTVTTIHSAMHDQQVIDAYHPDLRRTRAASQSIIPVDTKLAAGITRFFPQFNDRFEAIAVRVPTINVTAIDLSVTVKKPVKANEVNLLLQKAAQGAFHGIVDYTELPLVSVDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMATVAFR
The following text describes a protein:
Function:
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
Sequence:
MKLDLSVYLVTDSTPPILKGRDLCAVVEEAVKGGVTVVQYRDKKSDTGAQIETARKLHRITQAHGVPLIINDRVDVALAVGAEGVHLGQDDMVISEAKKLLPENAIIGISASSIEEAQAAVAAGADYLGIGTLFATPTKTNTKHIIGTAGTQAILDSIAESGRDVGTVCIGGINLSNVQRVLYQSASPRKSLNGAAIVSAIMAADDPRAAAAELARAIATPPPFVRKADGPLVRNVAGLLEKVPHIVQKMVEIHPLVHNMINFVVANFVANVTLAIGASPIMSPYGDEATDLCQFDGALLINMGTLTSQSPSEYLKAIRAYNQRGNPVVYDPVGAGATQIRRGVVKELMAGGYFDLIKGNEGEIRQVAGSTSVQQRGVDSGPSTLDHQGKARLARDLARREKNIVLLTGAVDYLSDGERIVAVENGHELLGQVTGTGCAVGTVAGCFIAANPTDKFLAVLSALLMYEIAAENAAARDSVRGPGSFATTFIDELYAIRQASLQGDHSWYAGRARVQEISL
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MDDYTQSINDAVKCLRQGGVIAYPTEAVYGLGCDPFNHDAVAQLLTIKKRSIKKGFILIASEWKQVEPLTEPIDPKALARVFDTWPGPFTWTFPASKEAPHWITGQHSTIAIRVTAHPLAKLLCQRFAGPLISSSANQEGEPPIRDVKILRLVFGNKIDKILEGPLGPTHRPTPIRDAITGEILRL
The following text describes a protein:
Function:
Catalytic subunit of the mRNA capping enzyme which catalyzes three enzymatic reactions: the 5' triphosphate end of the pre-mRNA is hydrolyzed to a diphosphate by RNA 5' triphosphatase; the diphosphate RNA end is capped with GMP by RNA guanylyltransferase and the GpppN cap is methylated by RNA (guanine-N7) methyltransferase. Heterodimeric mRNA capping enzyme catalyzes the linkage of a N7-methyl-guanosine moiety to the first transcribed nucleotide (cap 0 structure), whereas the methyltransferase OPG102 is responsible for a second methylation at the 2'-O position of the ribose (cap 1 structure). Also involved in early viral gene transcription termination and intermediate viral gene transcription initiation. Early gene transcription termination requires the termination factor VTF, the DNA-dependent ATPase NPH-I/OPG123 and the RAP94/OPG109 subunit of the viral RNA polymerase, as well as the presence of a specific termination motif. Binds, together with RAP94/OPG109, to the termination motif 5'-UUUUUNU-3' in the nascent early mRNA.
Subcellular Localization:
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome.
Domain:
The N-terminus contains the triphosphatase and guanylyltransferase domains, whereas the C-terminus contains the methyltransferase domain. The N-terminus is involved in binding to the termination motif 5'-UUUUUNU-3' in the nascent mRNA.
Sequence:
MDANVVSSSTIATYIDALAKNASELEQRSTAYEINNELELVFIKPPLITLTNVVNISTIQESFIRFTVTNKEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIVWEKKSLVTENRLHKECLLRLSTEERHIFLDYKKYGSSIRLELVNLIQAKTKNFTIDFKLKYFLGSGAQSKSSLLHAINHPKSRPNTSLEIEFTPRDNETVPYDELIKELTTLSRHIFMASPENVILSPPINAPIKTFMLPKQDIVGLDLENLYAVTKTDGIPITIRVTSNGLYCYFTHLGYIIRYPVKRIIDSEVVVFGEAVKDKNWTVYLIKLIEPVNAINDRLEESKYVESKLVDICDRIVFKSKKYEGPFTTTSEVVDMLSTYLPKQPEGVILFYSKGPKSNIDFKIKKENTIDQTANVVFRYMSSEPIIFGESSIFVEYKKFSNDKGFPKEYGSGKIVLYNGVNYLNNIYCLEYINTHNEVGIKSVVVPIKFIAEFLVNGEILKPRIDKTMKYINSEDYYGNQHNIIVEHLRDQSIKIGDIFNEDKLSDVGHQYANNDKFRLNPEVSYFTNKRTRGPLGILSNYVKTLLISMYCSKTFLDDSNKRKVLAIDFGNGADLEKYFYGEIALLVATDPDADAIARGNERYNKLNSGIKTKYYKFDYIQETIRSDTFVSSVREVFYFGKFNIIDWQFAIHYSFHPRHYATVMNNLSELTASGGKVLITTMDGDKLSKLTDKKTFIIHKNLPSSENYMSVEKIADDRIVVYNPSTMSTPMTEYIIKKNDIVRVFNEYGFVLVDNVDFATIIERSKKFINGASTMEDRPSTRNFFELNRGAIKCEGLDVEDLLSYYVVYVFSKR
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MYQYAPSHNLDHIEWNHAHLIYPPNLAIPTSPVNPPATQLNQPVQMTIDFDSIIEPKLGARESISWNRNGIIASIGDEGVETNLLVCTDGQDWVLTKPTLYAPKSILQPPTTSFVTPHRAFCHVEWSPSGSDLAIIDTLGSLYIYSQYTTLSPITCLRKPPSEELTTPIDLNAIVGFTWVAPEKPVILTNPGLKAGGNEKSKQKLSDVKDFPTGQTSQLLGYSGISVTYGVSQGLHLGPRIPQGFGACIGVTRSQVLKLWTQNGPSQPYNLVKLSLNQLHSDDIISHASFAGTKDHKMLLACYSPAGAIYLYRIEVEWSKEEEPKLRATRLLKETLMPQSGAPARLTDLKLFSIRSNQVSSETEAEMVCVFTDTKGATTNRYELQSHTPDLNSTFYSLGTNDSSASSTTTHKTHIISLVETTTSNKIVNIGSQVYDSIFFAAHEDGILNFRYRGNVSSSTKGTPFNMFSDAGYAFTPLPKGSDRPDYICVSPTCASYVYKTKDGLKLRIIDNKIPDADLTVAQMVDSAFVLSLRHSVSCISAVCNDDVMMVMRREIQRVSKLAPALETQFPLLLLAESHKAINFSLDLKKDHQMDKIMINPSLQRLLTMQTVIGTQHGWTRNVTSRLSWCFLNLRLVSFSLTFTLRAIGQQKPGVAPNHAMRIHYLMSLSGLKRWCLDFAAYLCQELLAASNEGPSYFQKQHVALPMVMARSSRMLLMYSWRGIRSLDTILMQKPGTETQEAGLASQRQRELSHFTPISMTFFEQLFNVIDSHTKQVAENVEDRLGLEQQLLFQGMIPQQFLPLAKRCVDEFDKFRKTNDLSPLYFYNVSWLGLDEHYDGRPAPTPAMAPYRNVTSTGLKIDCLRKFIIERQEGSILRVCQRCAGTSVFVDSSDGKQFTGTHWTFAFQRNCWCGGMWIPESLGV
The following text describes a protein:
Function:
Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells.
Sequence:
MHKKKAPPGPPGRGAAAARQLGLLVDFSPDGMMIPEDGDNDADLEAEFMALVGTQPPQELKSKAPLPMETIEKMASLCMKDLDEGEGEEEDDDDVEDDDELLAELNEVLGEREETQDTQNFPMAKSPNLPHPKISPSSAGMEATLAERLTMYQTAIINAKHAGDSSKVRRYERGVKTLENLLVSVKKGRNINEEDIPPPVAVGKSPIPTPESVIPTQPPQHQLPVAPPKTLPVPPNHGSGVTEKPAPVTSPVSSGPGIPGSLVLLQERQREYKRAALRSKQEGDSEAAAKYYRVAKSFDAVLDAMTRGEAVDLSRLPPPPDQMPKNLPSPGLQPPASTPSTGTISPSMPEMPPPPRTLLEALEQRMERYRVASGQAKDKGDDRKARMHDRIVKQYQDAIRAHKLGRSVDVTELPVPPGFPPIQGLETATTTQQSLVGVLETAMRLANQDEEEEETKKPSTHSLPSPQSKPQAPRTPGPGTGPPGKVAIKGSTKAQQQLAFLEGRKKQLLQAALRAKQKNDLEGAKLFLRQAKGLEPMLEASLNGLPVDITKVPPAPVNKEDFTLAHRPGAAISLEEAGHYAELTKLMRQQHEMCLKYSNQFTHLGNVVETSKFEKMAEDCKKSMEILKQAHSRGFPLPKFHYEQRTFSVVKIFPELNSSDMVLFIVKGINLPTPPGVSPSDLDAFVRFDFPYPNAEEAQKDKTNVIKNTDSPEFKEQFKLFIQRGHRGFKRAIQTKGIKFEVVHKGGLFKPDRVLGTAQLKLEALESACEIREILEILDGRRPTGGRLEVMVRLREPLTSQQLDTVTERWLVIDPLPPVAVPKTKAPPIPAPGRDQGSNRPGFSLKSLSVMAFDRERLERKIVAYKQARQAVPGKLAQQYQELVQHSQWQRAQLEQGGPGIRREYHAQLERYLQYYTEAARNLGSDGNRDAAKEALYKRNLVERELQQLRR
The following text describes a protein:
Function:
Major early eggshell protein.
Subcellular Localization:
Secreted.
Sequence:
MKCIAIVSTICLLAAFVAADKEDKMLGSSYGGGYGKPAAAPAPSYSAPAAAPQAYAAPAAPSYAAAPVSIPAPPCPKNYLFSCQPNLAPVPCSAPAPSYGSAGAYSQYAPVYAPQPIQW
The following text describes a protein:
Function:
Probable recombinase that does not seem to have a role in chromosome dimer resolution per se but rather may have some facilitative role during chromosome partitioning in general.
Sequence:
MQNKIKQLKNYAVYDDIEGFLINKDIRSSSGNSNYMMPSSTRRVSNTRKNYEGDIKQFFSVIKGKDVKSLVPDDLVVSKSELSNYVKYLQEKGLVNNSINRKMTSLKMLYTYLEHDYKDYIDLSVFNTVERLKTVTKNWDKTTQTEAERIAQDMYINERQKPLMKKLFVKFAIRTSFRVSAILRVRWKDIQLDESTGHYIVTVIDKGSQVVSTGINQVFYEELLQLKEEDDSETELVFQGLSEQSLRHSLKRSKKRLGIPPERELVLHSFKGVGIDYVYENSGHDLLAAKEQGNHKNTLTTERYMSRKINIANSAGVTMDEKIDLNPLYEATQEDFISFFENADLVTLKKFIKHVNER
The following text describes a protein:
Function:
Proton-selective channel gated by extracellular protons.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGRGARAAAAQSRWGRASRASVSPGRTIRSAPAVGEAQETEAAPEKENRVDVGAEERAAATRPRQKSWLVRHFSLLLRRDRQAQKAGQLFSGLLALNVVFLGGAFICSMIFNKVAVTLGDVWILLATLKVLSLLWLLYYVASTTRRPHAVLYQDPHAGPLWVRGSLVLFGSCTFCLNIFRVGYDVSHIRCKSQLDLVFSVIEMVFIGVQTWVLWKHCKDCVRVQTNFTRCGLMLTLATNLLLWVLAVTNDSMHREIEAELGILMEKSTGNETNTCLCLNATACEAFRRGFLMLYPFSTEYCLICCAVLFVMWKNVGRHVAPHMGAHPATAPFHLHGAIFGPLLGLLVLLAGVCVFVLFQIEASGPAIACQYFTLYYAFYVAVLPTMSLACLAGTAIHGLEERELDTVKNPTRSLDVVLLMGAALGQMGIAYFSIVAIVAKRPHELLNRLILAYSLLLILQHIAQNLFIIEGLHRRPLWETVPEGLAGKQEAEPPRRGSLLELGQGLQRASLAYIHSYSHLNWKRRALKEISLFLILCNITLWMMPAFGIHPEFENGLEKDFYGYQIWFAIVNFGLPLGVFYRMHSVGGLVEVYLGA
The following text describes a protein:
Function:
Scaffolding protein that facilitates the localization of proteins to the cell membrane. Required for the correct formation of tight junctions and epithelial apico-basal polarity. Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier. Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells. Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries.
Subcellular Localization:
Apical cell membrane; Peripheral membrane protein. Cell junction, tight junction. Cytoplasm, perinuclear region.
Sequence:
MKLQEKGDASQNEKLSVFYETLKSPLFNQILTLQQSIKQLKGQLSHTPSDCSTNFDFSRKGLLVLTDGAITNRNAHRPSSNLTVSGLFPWTPKSGNEDFHSVIQQMAQGRQVEYIDIERPSAGGLGFSVVAVRSHTLGEVDIFVKEVQPGSIADRDQRLKENDQILAINHTPLDQRVSHQQAIALLQQTTGSLHLVVAREPVHTKSSASTSPPDTTLPETVRWGHVEDVELINDGSGLGFGIVGGRSSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGDSVRMLVARDPVGEVFVTPPTPSALPVALPALANSAPSSDKSALFETYDVELIKEDGQSLGIRIIGYAGTPNTGEASGIYVKSVIPGSAAHHNGQIRVNDRIVAVDGVNIQGFANQDVVEVLRNAGQVVRLTLARRKTSSSASPLELPSDRGAVVEPPKTPTLFLTGAVETETNLDSEDEDTEERMDNLKTNSVQALERLGVPDFPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGMEVDSFEGHHYISSIAPGGPVDTLNLLQPEDELLEVNGVRLYGKSRREAVSFLKEAPPPFVLVCCRRLFDDEASVDEPRAPVASPPETQSLKNMKIYDQFRRESNDCCNSRRKADHSVDVNPEEDDDGELALWSSEVKIVELVKDHRGLGFSILDYQDPLDPTRSVIVIRSLVVDGVADRGGELLPGDRLVSVNEHSLDNSTLAEAVEVLKAVPPGTVRLGICKPLVEDDNEEESHYILQSNHHEDRTEISGTIHDINSSLILEAPKGFRDEPHFKEELVDKPFLDLGKSFQSQQKEVDNSKEAWEMHEFLTPRSQEMGEEREMLVDEEYELYQDGFQPTELYSPSRVQEAARVPSVEGLHLGAQRLHGAREDGEPAQPQEARALLGVCPPEAQQWGCGPDDLMKEDFGIDASPSVPSPEGSGQQGRFGGLENLSSFPQSSSDLGMMIPDDVQAPGLLVELPAVAQRREQEDLPLYQLPRTRVVSKASAYTGILSSRYATDTCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHREAVEAIQNAGNPVVFVVQSLSPTPRVIPSVHNKANKIANNQDEDTQEKKEKRRGTAPPPMKLPPPYKAPSDDSDENEDGDVFTNKKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAATDGRMRIGDELVEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVAPFPLPSSPPSSLEEDVPQLVGQGVVAGQQQALECPTDSAVSQMKQQQYSAQVSLGSQDIPLAPAPSYSSTDADFPGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLDAIVIHEVYEEGAAARDGRLWAGDQILEVNGIDLRSASHEEAITALRQTPQKVRLVVYRDEAHYRDEQNLEIFPVHLQKKAGRGLGLSIVGKRSGNGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATVLKCAQGLVQLEIGRLRAGSWTSLRKTLQNSQGSQHSTHSSCHPPLPPVVSSLQNLVGAKRASDPSPQNPGMDVGPRTVEIIREPSDALGISIAGGRGSPLGDVPIFIAMIQASGVAARTQRLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIATQLENMSAGYHLGSPSAEHHPDDTETPPPKTIALEKGSDGLGLSIVGGYGSPHGDLPIYVKTIFAKGAAAGDGRLKRGDQILAVNGETLEGVTHEQAVAILKRQRGTVVLTVLS
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system.
Sequence:
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVFISKKDSSLSKDSVINVSQIVTLDKERFLNKAGKLKSNKLGEVEIGLKLVTGLD
The following text describes a protein:
Function:
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Sequence:
SELDGSKLQIGILRTRWNDEHVSNLVDGIKAGLKGCKVDEDKIFIKEVPGAYELPYAAKLLAMSGTVDAIICCGVLIKGETLHFEYISEAVSKGIMDVNLSTMTPVIYGVLNCLDEEQVKKRSSNENGGHNHGEDWGKTAVEM
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTLVCPLSGCVHSSFIRTLSTGHSTAKLPLQTSMPPKRIQTPSSSSLSSGPAVLSSNSSVFQIAHHVWQQYLTTTPQRTMMLDAFMVFLLFVGAVQFLYCVLAGNYPFNAFLSGFCAAVGQFVLTASLRMQTSSELKGVNSKPSSKGKNARFAAVEGGEQQGAVSHERAFADYIFGSLILHFFCINFIN
The following text describes a protein:
Function:
RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation.
Subcellular Localization:
Nucleus.
Sequence:
MNVIHRQHLPPSGVEFSCQASLTPSTLPRYSELIRSSKTRPRPITNLIVARSTLLQVFELCLVEDDQAENNHTRNHHELKNKNYKLFHLCEHRLHGRVTGLQRLTTLDTQEDGLDRLLVSFQDAKMTLLEWSNSAADLVPISLHTFEKLPQITQGDLPRDFQGQLEVDPLSRCAVLLLPQATLAVLPFFQDQLDLDSLGLSGGLKSALGSEQQRFQTFPYASSFILDFNQQLLNHLPPSSLDSQHRPIKSVIALKFLPGFSEPTLAVLYQSQYTWSARLENHANTAALIVLTLDLGSNHFPIISHTTNLPYDAHGLVACPKELAGVLVLCADMILHVDQSSKIIGLATNGWVKHTSELQIPRQDTVRLITPTNKISGHRSTTNKSDERPEDLEDGEEQDESGVPEGHEKLLVRLENAKIVFSRADRAFVFLRTGEVFSLQFLRDGRTLTKLVLEKLDLLSIIPSTVLKVNNECLFVGSMAGDSALYILDHLRPRSSSDDDNDDGHQLPSSSIIQPDKAAKNQSSLDFDEDIYGDRTETDPVRRTDHSQLYDDRPSNGADDGRPGAGAHLAEPFLRLGDVIQAHGPIRDFTMAATGVENMPLELLACTGTGDLGGLTVFHREIPLRKRRKLSFESPSASHINALFFTSLVVESGGLSEERKVVWMGRSGPRTEIATYGESGELSLINTFPEKTLAVSPFFGKQFVVQVTNTAIKLFTSSLEEAQVIQPEPAVKILRASIVDDYVMLETHCGLKLIYQGDHDSKTLSKLPFPSDTDEIETASLLKAALPIYTFKHAANHQFFTKRKAGNEDDDLYNNGPTDANGDVEMNNNDANDQEPHKPQNPDVCGDACWLLTTTKNGCFHIRSLPTLAIVFTATRLDLLPETMAEEDKLEGDAQPVELFGLVDQAAPVEPIAHIFGFLTGAIASRPHLAVMLKNGALAVYEILCSFTIPLRLSEKDGHPAVLLKKVIGRQFEAVENVDEVSGVESEDHEMGRTTEIDEQISPQSRSFTSIQMDGKFKGVYLAGQPPVWLLSTDHGPCRIYDSPDEKTIHGIAQLPDGFLMSLSEASVQDEEPSQACDPASLWETYISEYVCLDREIPSTLVKTGRPFNKVFYDSASETVVGASYLETAFANFDEEGNLMWQPDDDSLIRATTFRSSLELILPGKWVTIDGYEFQQNEWVTSMANVELDSRSTVSGRRQFVGVGTTCNRAEDLAARGGIYVFEIVVVNPAQNHRTYNRALRLRYYEETKACVTAVDAINGYFLHTMGQKLYAKCFEQDERLLAVGFLDIKPYTTCMRIFKNFILLGDAVKGITLVAFQEEPYKLIELGHTYVDLKCSTIDFLVIDGKLAIVATDLNGVIRIFEYNPTNIESQGGQKLLCRSEFNTSSEMTCSMQFGKRLSAKDEAKVMGTFFASLDGSISSLVPAKEAVYKRLQLVQTRLTRHIQHFAGLNPKGHRTVRNDLVSRAINRGILDGELLIKFHLLSVTQQAEIAGLAGSDRETVLVNLLNLRGLW
The following text describes a protein:
Function:
TATA box-binding transcription factor. Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MSSQSSPISLTNNDLEISSNNNKPIIKQLPVPTNEIEKPVIQNIVATVELDCTINLQDVVRRVRNAEYNPKRFGALIIRITNPKTTALVFHSGKLVVTGGKTVDDSRLAGRKYARILQRLGYNVKFNHFKIQNVVASCDMKFAISLKELIQLAPKITKYEPEIFPGVVYRLADPKMVLLIFASGKIVFTGGKEIEQINKAFSEIYKILLQVANNDN
The following text describes a protein:
Function:
Hepatic lectin is a membrane receptor protein that recognizes and binds exposed N-acetylglucosamine moieties of plasma glycoproteins, thus mediating their clearance (from the circulation) and endocytosis.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MDEERLSDNVRLYKGGSIRQGLRSFAAVYVLLALSFLLLTLLSSVSLARIAALSSKLSTLQSEPKHNFSSRDSLLFPCGAQSRQWEYFEGRCYYFSLSRMSWHKAKAECEEMHSHLIIIDSYAKQNFVMFRTRNERFWIGLTDENQEGEWQWVDGTDTRSSFTFWKEGEPNNRGFNEDCAHVWTSGQWNDVYCTYECYYVCEKPLPK
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MSWSLPGWTRQPGTFQLVLGYGKNPSPNPAGQADPQPSGIEDSSKSGSDGEKTDAAAECKIRVQLEWGAGEDEEGVVLKLQSQLMMALPYPEEQVQVRMVPQSEAAQTTPEATIPPQNPGPSEPPGPNGTDAKSPGSARTGDVSPSSSWGFLDRLAASMGRNPNAESAPSTPAPLADVRGPSAASSDGPHVGTVSKGPDEKPDGSVRGFGLRTASHERLKLHDDAHSDSETFEDAPHSFPPTIDTASLVPTPSVPAAPGVVSSAGKVPVRTVVKKRSERLRVILVSRTAGSGPSGEGVGVLNKIVEESEIPGVEHLALTEGVLGFWEKRGADAWAGLRTLNLSGCNLSVVPPGIAQLPSLEVLLLDNNKLVAPPADLGKLTSLRKLSMDHNLLLSVPIELRECTSLSELSLEHNRLVRPLLDFRSMARTLQTLRLFGNPLEFLPEILPCRKLRQVSLANVRIEGDAELTSVEVHVEDDAGATSYYFGGAKHRLSTFFQLIFRYSSCQHPLLASALARIAEDGENRAYIGRDEGAIRQLLSMVLSDDTHVVQQACKALSCIAMDATLVARLVKADVLQSIWAVLGSTEPEIQVSVLQVLASVAFCSNSIAARLFTPDMLHRLKELCGSENALKVREEALLVLGNLAFSPSNRRAMASAQGLRSLLAKIALTEPAEDAPNPSQNHPKPSQKPVLGRPKSSPDLTNMKSAKLSHSSSEPSHKPGEQPSPPEGSPFSSPPAFRDFTGAPKTSAHGSAARVRASAVRALAIMGENELVRKSTGRRPLGSRGVKILSLDGGGMRGVATVRMLRRLEKGTGRRIHELFDLICGTSTGAMLAVALGVKEMSLDECEGIYKRLGKIVFAADDKDKEKDAASFATWREKLDLMYKSGAQNLRVVIHGAKHDATQFEGLLQEMSAFEDGRNLLIETAGRGGPKVSVVSTLVSVTPAQPFVFRNYQYPPGTRESAPWAAPVTPLSPQINPGQPAFGGGGGGGLAATPAPTPVQSRVGMGHVAYMGSCKHLVWQAIRASSAAPYYLDDFSDGNNRWQDGAVTANNPAIIAVREARLLWPDVQIDTVVSLGCASLPTKPRGKNWKHVDTGSVLIESACSVERVEEAMDTLAPLVPNLEYVRFNPVDESGAMELDETDPAQWARLEAATQDYVDLHDARFAALCARLTSDLPEPSERATVASESTKPASESRNPASGSVTSAPETGNPASERATSATGAEKPASVGVTSVAETGTLDEDADAPLLRLRERSVGKGTGGKVGKENGGGTGENGGGVTEESQTEGRSQESESEEENGDDDFADLSGLRRKIVHSKSRNAGRLEESVDALGGRELDRGFSFSQSFAFGGLDAGDEVPVEPRVESVTQDAIDLNPTATWQADGGAPSATWQVERGAPLELVPVNEVPESGASKTIANRSKLDQGNVTSERPAGAPRTQDAAAPPRGLEVSKRSAAAVALGLRKGLLFVEAAPGPAAAEGFGVWADGASLLHHSASHRPLIDAVCEQNKISRDVFDGRIHTGIKPAKPAVLTRPLSSPSLPTPVKPISRSNSLTKLSTARPPSPGAGLARVNVNRESRDGEAPSEPEEALGFPAQALYERLQTARSVGVVHLALSGDQRGLVVGWQSDVVAVAEPGEEARAFLGSLSGGMRYGSVAELCARHRQFDVGAAVLTLIGRHTQLLPGGEEVGAFVFRRTVPSAFLTADDVRKMVGVWRDRIVVSSRFALTQPVIEALLDGGAKAVFELALSDGGPADLDGNGMASGEATTDASNSWGSAITPVVRSVFTPAVDQAPTPASKGKQRSETDFLYSTDFDRPGDSVLEELLASFYSALYEEGLSVDQVEAAVQRSGSRGGCRLICHLPSH
The following text describes a protein:
Function:
Required for cell migration during body enclosure and cell shape changes during body elongation. Required for proper localization of other junctional components, such as pac-1.
Subcellular Localization:
Cell junction, adherens junction. Cytoplasm.
Sequence:
MPANGNSHAYFNIDEVRSKNVLKQITQLINEVTNITETFPLKPGQTTEGLVATLDAAVANFLQTGSFAISKCPIANSDPRAIDLLHEALGAVQDTGQVMIQTGRDFVRDSTSTNKRAIATNSGRNLLTAVAKFLILADSIDVKVIVDKVDEVRETAHQMIEADTKIKVDDLYNLLISQIEELDITVRRRAIDLVKPNQRDDLLAARSALRQTAPLLYTSTRTFVRHPEHEEARRNRDYTADEMHSALNALESVLNGQQPKVTFSEYGRIGDLINEIDTFQNRIEIDPAHYRRGTDRPDLEGHCERIVSGSASIADAESTRENRKQKIVAECNNLRQALQELLTEYEKSTGRRDDNDDIPLGIAEVHKRTKDLRRHLRRAIVDHISDAFLDTRTPLILLIEAAKEGHEENTRYRSKMFQEHANEIVSVARLSCQLSSDVESVSVIQHTAAQLEKLAPQVAQAAILLCHQPTSKTAQENMETYKNAWFDKVRLLTTALDNITTLDDFLAVSEAHIVEDCERGIKGITANASTPDENAANCETVDCAAGSIRGRALRVCDVVDAEMDFLQNSEYTETVKQAVRILKTQRVDQFAERASALANRQEAHGLTWDPKTKEEEMNEFINACTLVHDAVKDIRHALLMNRSMNDVDSDVEYEADGVGAANADANRTISEQENQQNLMRRLPEEEKKKIQAQIDIFKVTQTRFEREVAKWDETGNDIISLANNMCKIMMSMTEFTRGCGPLKTTMDVIRAAQEISLNGSKLNALARQIGEESADSQTKKDLLAYLSQITLYCQQLNICSKVKADVTQVGNELVVSALDSAMSLIQTARNLLTAVVQTVKAAYIASTKFRRPNANSVRVEWRMAPPKKQPLIRPQKNNAIIRRASERRPLQPAKVLAEFTRNEIETGRDSDDEELDRRHQQRINGRL
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
Subcellular Localization:
Cellular thylakoid membrane; Single-pass membrane protein.
Sequence:
MLNTLFILAAEAHEAGEGGFGINLDFLEANLFNLAILLGIIIYYAPKTLGKILGDRRQKIADAIEEAETRQRKSAQILAEEEKKLAQAKAEAARIVQEAGQRAEVAKQEIATQTEADLRRMQEAAAQDLGAEQERVIAELKRRIAEQAVAKAEADLRDRLNEDTQDRLIERSIAQLGGR
The following text describes a protein:
Function:
Integrin alpha-10/beta-1 is a receptor for collagen.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Sequence:
MELPFVTHLFLPLVFLTGLCSPFNLDEHHPRLFPGPPEAEFGYSVLQHVGGGQRWMLVGAPWDGPSGDRRGDVYRCPVGGAHNAPCAKGHLGDYQLGNSSHPAVNMHLGMSLLETDGDGGFMACAPLWSRACGSSVFSSGICARVDASFQPQGSLAPTAQRCPTYMDVVIVLDGSNSIYPWSEVQTFLRRLVGKLFIDPEQIQVGLVQYGESPVHEWSLGDFRTKEEVVRAAKNLSRREGRETKTAQAIMVACTEGFSQSHGGRPEAARLLVVVTDGESHDGEELPAALKACEAGRVTRYGIAVLGHYLRRQRDPSSFLREIRTIASDPDERFFFNVTDEAALTDIVDALGDRIFGLEGSHAENESSFGLEMSQIGFSTHRLKDGILFGMVGAYDWGGSVLWLEGGHRLFPPRMALEDEFPPALQNHAAYLGYSVSSMLLRGGRRLFLSGAPRFRHRGKVIAFQLKKDGAVRVAQSLQGEQIGSYFGSELCPLDTDRDGTTDVLLVAAPMFLGPQNKETGRVYVYLVGQQSLLTLQGTLQPEPPQDARFGFAMGALPDLNQDGFADVAVGAPLEDGHQGALYLYHGTQSGVRPHPAQRIAAASMPHALSYFGRSVDGRLDLDGDDLVDVAVGAQGAAILLSSRPIVHLTPSLEVTPQAISVVQRDCRRRGQEAVCLTAALCFQVTSRTPGRWDHQFYMRFTASLDEWTAGARAAFDGSGQRLSPRRLRLSVGNVTCEQLHFHVLDTSDYLRPVALTVTFALDNTTKPGPVLNEGSPTSIQKLVPFSKDCGPDNECVTDLVLQVNMDIRGSRKAPFVVRGGRRKVLVSTTLENRKENAYNTSLSLIFSRNLHLASLTPQRESPIKVECAAPSAHARLCSVGHPVFQTGAKVTFLLEFEFSCSSLLSQVFVKLTASSDSLERNGTLQDNTAQTSAYIQYEPHLLFSSESTLHRYEVHPYGTLPVGPGPEFKTTLRVQNLGCYVVSGLIISALLPAVAHGGNYFLSLSQVITNNASCIVQNLTEPPGPPVHPEELQHTNRLNGSNTQCQVVRCHLGQLAKGTEVSVGLLRLVHNEFFRRAKFKSLTVVSTFELGTEEGSVLQLTEASRWSESLLEVVQTRPILISLWILIGSVLGGLLLLALLVFCLWKLGFFAHKKIPEEEKREEKLEQ