lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MFRSQEMSYFQLIMPQDSAWTIMDQLGYLSKVEIIDHNPNEALINRPFANYVKRCDDLIVKIENMLQVAKNLNLLSNYKKGNLKQFTNQVFHIIQLFHTYLDKIEDDINKKTSSFQEQNKHLEQLIDQSEYIQNYIEILKESKTYLGEQVFQNQQISKFECYVGILKNLEQLQFHRVIFRVTKGNSMVHLKRMNEKQSIFIVLFPNIGNYGKQKIQKIVEQVSQGKFTLPQSHQEFEKKLNELQMKQAEYINLIQMTQNQLCQCISNMLVLRNGLPLIEFYKFYLIKEKDLYKELNKLKMQGRLFLGELWVPTKDIFQLEQTLQMIKEQQTNNPGGQLAQKYPPDFLQKPTYFKLNEFTSIFQEIVNTYGIPRYQEINPAIITIITFPFLFGVMFGDIGHGFTLFMFGSYLCLFKNKSFYNLRYLILLMGVFSFYSGLIYNDYLSLSLNLFQTCFRSEEECVYPFGIDPMWGGHLEFNDSFKMKLSIIIAFCHMLLGISLSGLNYLFLGDWLKLSCKFLPQLLFLICTIGYMVFLIIYKWLNHFEPQNAPSIITTMISMILNLGRISGPQMWEGDSQDYIQYCLLLMTIISIPWMWFPSIISHLLQQGSFQQNEGKRKTHRIDYGQLVEEPGIEMTQTHSYSHEQIDTKYGQPNGETQESTFFIKQKNTSHQGIQDLIVHETIETLEYVLGVISNTASYLRLWALSLAHSQLSEVFFELLLVQPINHGQPISLMIGFPFWALITFGVLMCMDSMECFLHSLRLHWVEFQNKFYKGDGVQFKVFSFRDRIKESINLESQ
The following text describes a protein:
Function:
Central component of the spindle assembly checkpoint.
Subcellular Localization:
Nucleus.
Sequence:
MSQTGDSSSFVEEPASPEARQRELERQVLGLEYRLRTEHSEAEMARLALERELAGMQGKYKQCMGELEAALADTRYLYEQNAALEARARAADEDAGGAAAAERAAAAEERARAAEARARELEEALQAARGEAAAAGRAAAGAAAGAAAAEQSGLLRKYEAEIERQMGELRALAERLAEREDEVAGLKAQRVLQAHRSYSAEEVEELGVLRRTLQEQLALSKELERANLEQANELKRLRQRSESQQFLQLENSKLRARLEKTDALRQQLDDLQLENVQLQEKLTKWEVYQADGSSPENVLHEMALAKQERLALVEQVGKLQLDLNNMKILNDELALERNQLLDLNKKYESSILNLKKLNYEIEQQKLLSFEECKLLRQQLDDLSEVDKDHTPDTRDRKKIQTLVDTYKNQTEDLTNELKKLNEQLLERSDLDGNPRKRRKASDDLAFNYSQRLNELQLRNKDLERRLANSDENASLLEEKLRKLQSLNEKKIRILQLRNNPLLKDQFVKQKQLTLLKQENLELAQQLDAQQGLEAVPRSVYERQQYDIQLLEDELFSINKRTTRLKEMFNRKSLEFIDAVNSLLGFKLEFQVGGKVKMIPCFKTDRYLIADLQTNTLKSNLDKVMPEWDAMLAEYVGKRQQLPCFLAKIMLLLAESSSSQ
The following text describes a protein:
Function:
Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.
Subcellular Localization:
Chromosome.
Sequence:
MSHGPRQPGAATAPAGGKTPGQHGAFVVAVKQERSEGPRAGEKGPQEEEARPRPHAPDPAHSSQSPSQGHSPLLQPVKKRGWPKGKKRKKILPNGPKAPVTGYVRFLNERREQIRTRHPDLPFPEITKMLGAEWSKLQPAEKQRYLDEAEKEKQQYLKELWAYQQSEAYKVCTEKIQENKIKKEDSSSGLMNTLLNGHKGVDCGDGFSTFDVPIFTEEFLDQNKAREAELRRLRKMNVAFEEQNAVLQRHTQSMNSARERLEQELALEERRTLALQQQLQAVRQALTASFASLPVPGTGETPTLGTLDFYMARLHGAIERDPAQHERLIARVKEILARVASEHL
The following text describes a protein:
Function:
Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
Subcellular Localization:
Nucleus membrane; Multi-pass membrane protein. Nucleus, nuclear pore complex.
Sequence:
MAKNWLISQEFIWRNAAAAVWTWVVNSSWLLVALFVWTFTPSNHIYAVYDYFLLLFSFRVWVLIFCISCLSSLFVKLHMQGSKVTCKLPTTRFQSLVAMFSFKRIFLTMCHGVLCGVITAFLAGITESKFSTVYIQCKNTPDYVCLNESCYILILFGSVVGAANFVSRSNKHLYCLNFPIVQQARFISIKCNFHQMLVQSYKTCAKFLQYFLIFYYLIGYLTREFVADLFRAGPCDGHIVSTLNIMGVISLAWTLWVSGTILLLLHDVSWHLFNIYATKMFPFRMDSVFPEDKPKILTSNLTSDQPLLVQHLAFQYLSSIASSSSIKRKQIYIISHDTGSANQPKWNLILDECLARLKKLTTSIKDHKQIALRMEQNKVKTTKSSKSSSSSQSSSGQSPAPDSSQFMSVSAFNHRPKSCDTLDGVNMSCFDVSSLNTTNAGNPLNSPNLNGSMLTVPTPKLWTKQIRKRAALHSNVSSPVPIIQPYQEVPQVPYKTLNSQIQALLQRGASAIKKFPVVSFLFNEIPSHSMANLYSEHNIYRWSIRSLSSLSAYSLNEDDYGVVQRRLHEVINCLLDLVVTLDKHGKVLPICTSETTNLMLRQQQSIKNEAKSAVYRITDTFSTQLESIPVDAEFRRKLRSFVEHQE
The following text describes a protein:
Function:
Displays thioesterase activity against medium- to long-chain acyl-CoA substrates. Is involved in the thioesterase-dependent beta-oxidation pathway of (9Z,11E)-octadecadienoate (conjugated linoleic acid or CLA), along with TesB and FadM. In vitro, is active against decanoyl-CoA and palmitoyl-CoA (hexadecanoyl-CoA), but not with acetyl-, butyl- or benzoyl-CoA. Lacks general lipase or amidase activity. Likely plays an important and specific role under natural conditions in permitting the metabolism of unusual carbon sources.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAVLTAEQALKLVGEMFVYHMPFNRALGMELERYEKEFAQLAFKNQPMMVGNWAQSILHGGVIASALDVAAGLVCVGSTLTRHETISEDELRQRLSRMGTIDLRVDYLRPGRGERFTATSSLLRAGNKVAVARVELHNEEQLYIASATATYMVG
The following text describes a protein:
Function:
Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0.
Subcellular Localization:
Nucleus.
Domain:
The CW-TYPE zinc finger mediates its binding to trimethylated histone H3K4me3.
Sequence:
MLLYRGAPAGPGAPGCGLARPGGGPQAFGIRLSTMSPRYLQSNSSSHTRPFSAIAELLDNAVDPDVSARTVFIDVEEVKNKSCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQCPIGVFGNGFKSGSMRLGKDALVFTKNGGTLTVGLLSQTYLECVQAQAVIVPIVPFNQQNKKMIITEDSLPSLEAILNYSIFNRENDLLAQFDAIPGKKGTRVLIWNIRRNKNGKSELDFDTDQYDILVSDFDTEEKMTGGVTSELPETEYSLRAFCGILYMKPRMKIFLRQKKVTTQMIAKSLANVEYDTYKPTFTNKQVRITFGFSCKNSNQFGIMMYHNNRLIKSFEKVGCQVKPTRGEGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINALAQKLNAYWKEKTSQDNFETSTVARPIPKVPDQTWVQCDECLKWRKLPGKIDPSMLPARWFCYYNSHPKYRRCSVPEEQELTDEDLCLSKAKKQEQTVEEKKKMPMENENHQVFSNPPKILTVQEMAGLNNKTIGYEGIHSPSVLPSGGEESRSPSLQLKPLDSSVLQFSSKYKWILGEEPVEKRRRLQNEMTTPSLDYSMPAPYRRVEAPVAYPEGENSHDKSSSERSTPPYLFPEYPEASKNTGQNREVSILYPGAKDQRQGSLLPEELEDQMPRLVAEESNRGSTTINKEEVNKGPFVAVVGVAKGVRDSGAPIQLIPFNREELAERRKAVESWNPVPYSVASAAIPAAAIGEKARGYEESEGHNTPKLKNQRELEELKRTTEKLERVLAERNLFQQKVEELEQERNHWQSEFKKVQHELVIYSTQEAEGLYWSKKHMGYRQAEFQILKAELERTKEEKQELKEKLKETETHLEMLQKAQVSYRTPEGDDLERALAKLTRLRIHVSYLLTSVLPHLELREIGYDSEQVDGILYTVLEANHILD
The following text describes a protein:
Function:
Pore-forming subunit of two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (Probable). Assembles with ORAI2 and ORAI3 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. Activates NFATC2/NFAT1 and NFATC3/NFAT4-mediated transcriptional responses. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription. Assembles with ORAI3 to form channels that mediate store-independent Ca(2+) influx in response to inflammatory metabolites arachidonate or its derivative leukotriene C4, termed ARC and LRC channels respectively. Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion (By similarity); [Isoform alpha]: Pore-forming subunit of both CRAC and ARC channels. Couples Ca(2+) influx to NFAT-mediated transcriptional responses; [Isoform beta]: Pore-forming subunit of CRAC channels exclusively.
Miscellaneous:
MISCELLANEOUS: In Greek mythology, the 'Orai' are the keepers of the gates of heaven: Eunomia (order or harmony), Dike (justice) and Eirene (peace).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Upon store depletion, colocalizes with STIM1 in membrane punctae at ER-PM junctions; [Isoform alpha]: Cell membrane; [Isoform beta]: Cell membrane.
Domain:
The Pro-rich region of ORAI1 (residues 3-47) functionally interacts with the polybasic Lys-rich region of STIM1 (residues 672-685) and regulates CRAC channel gating at negative membrane potentials; [Isoform alpha]: AKAP5 association region (AKAR) mediates coupling of ORAI1 to AKAP5-dependent NFATC2/NFAT1 transcriptional responses.
Sequence:
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
The following text describes a protein:
Function:
Putative transcription factor involved in the regulation of the activity of the cAMP/protein kinase A pathway. Involved in sterol uptake. With SUT1, positively regulates mating by repressing the expression of the mating inhibitors NCE102, PRR2 and RHO5 in response to pheromone.
Subcellular Localization:
Nucleus.
Sequence:
MKPNNRTCDVITNKDESLPALLLPALNSYTCDDSLLKGQISSNGRYQPFGFSDCSLLPKRLNIQAGQGSMPVSSIQCADHSYSNWQKESEKTKLPKLGCPTEYTEYYKTVSSGETTDSAVVSSIATNRLKRKRQRDGPSCDSCRIKKIKCNATIIIFLQDRNLISSISSNLHYTLSQDDINQFRMKFFRKLPDVMGTYEVIKHLDKIVLFKACTSCSRRNQKNGKCLFSRGFTKSDMNVFPKINSKLKDKSIFEMTVDDYVAAGFQTL
The following text describes a protein:
Function:
Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MASRAGPRAAGTDGSDFQHRERVAMHYQMSVTLKYEIKKLIYVHLVIWLLLVAKMSVGHLRLLSHDQVAMPYQWEYPYLLSILPSLLGLLSFPRNNISYLVLSMISMGLFSIAPLIYGSMEMFPAAQQLYRHGKAYRFLFGFSAVSIMYLVLVLAVQVHAWQLYYSKKLLDSWFTSTQEKKHK
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).
Miscellaneous:
MISCELLANEOUS: Present with 20000 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus. Note=Associated with ribosomal chromatin, even in the absence of transcription.
Sequence:
MGSSLDLVASFSHDSTRFAFQASVAQKNNVDIYPLNETKDYVVNSSLVSHIDYETNDMKVSDVIFFGWCSDLIDTQSSNIKRKLDEDEGTGESSEQRCENFFVNGFPDGRIVVYSSNGKDIVNIIKNKKEILGADTDESDIWILDSDKVVKKLQYNNSKPLKTFTLVDGKDDEIVHFQILHQNGTLLVCIITKQMVYIVDPSKRRPSTKYSFEISDAVACEFSSDGKYLLIANNEELIAYDLKEDSKLIQSWPVQVKTLKTLDDLIMALTTDGKINNYKIGEADKVCSIVVNEDLEIIDFTPINSKQQVLISWLNVNEPNFESISLKEIETQGYITINKNEKNNADEADQKKLEEKEEEAQPEVQHEKKETETKINKKVSKSDQVEIANILSSHLEANSTEILDDLMSGSWTEPEIKKFILTKINTVDHLSKIFLTISKSITQNPWNEENLLPLWLKWLLTLKSGELNSIKDKHTKKNCKHLKSALRSSEEILPVLLGIQGRLEMLRRQAKLREDLAQLSMQEGEDDEIEVIEHSNVISNPLQDQASPVEKLEPDSIVYANGESDEFVDASEYKD
The following text describes a protein:
Function:
Hydrolyzes 6-sulfate groups in N-acetyl-d-glucosaminide units of heparin sulfate and keratan sulfate.
Subcellular Localization:
Lysosome.
Sequence:
MQLLPLAPGRLRQGSPRHLPSCSPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSFLPILRGASNLTWRSDVLVEYQGEGRNVTDPTCPSLSPGVSQCFPDCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKSIDPELLGKMNYRLMMLQSCSGPTCRTPGVFDPRYRFDPRLMFSNRGSVRTRRFSKHLL
The following text describes a protein:
Function:
Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLRNRLIDGVRRIKPILCGGQSLRSLANGATSKLTTIEVDDRSGIATLSMNLPPVNTLTMELMHDLIDSINQIESNKSRGLILTSSNDKVFSAGLDLNEMLNPDVERLRLFWTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFVISKWMMNSYQSVLPRRIVERALNQGKLFASQEALDVGLVDEIACSKEEALSKCAAFIATFDKTNPVARCLTKRMCREPDVRELLQDRAADLKECVDYVTTPLFQEGLCAHLEGLKKRK
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAGGFLNTPIWRSSPMQMVQLFVQIEAAHDTVDELGKLGLIQFKDDNENVNLFQRNFVNEVKRCDEMEKKLRFFEEQIRKEPRLAKQLPESLLNIPNDESQMDELEVRFDELEAELKQANTNQETLQRNYNELIQLSHVLTKDSVFFQENPNLIEAQNNVEHSARSPLLADQEQQISEAAKQGVKLGFITGVMNTDKMPQFQRSLWRTTRGNNYVKDARIDEEIIDPHTGEETAKTVFIVFFQGDRLQQKIKKICESFGANIYDCPDNSFERSNLLQKVTIRINDLSEVLQRSKEHKKQTLLGIVPQLFSWKAKVLKEKSIYHTMNLFDYDVGRKCLIAKGWTPKDKIEEIQLALRTATTRSGALVPSVLSVIKTDETPPTHFETNKYTNSFQQIVNAYGVAHYREINPAVLTIVTFPFLFGVMFGDVGHGALLLLSSIGLIAIEKKLAGKKLNELIQMPFDGRYVLFLMGLFSIYVGFIYNEMFSIPMNIFGTQYTACYNPAASPFCLTKAQASARPNVNYNDFGNNNTYPYVSWYNYTNVERTYPFGVDPLWKGAPNELVYYNSFKMKLSILFGVIQMTLGIFFSFLNYLNQKGPIKFVNIFTQFIPQLMFLWGIFGYMSVLIILKWVIPYHANGTDPPFILPTIIDMFLQPGGALPVSFFEGQSKLQPALLLLSLLSIPIMLIPKPLFMKKFHNDEMERKKNGHHEEEHDDEALYIGHHGEEFEMGEVFVHQVIHTIEFVLGAVSNTASYLRLWALSLAHSELSSVFWERILIGQVEGGNPALAFVGFGAWLGASVAVLLMMESLSAFLHALRLHWVEFQNKFYIGDGVTLNAYSHEKILSGTEEEE
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
MKNKLFAAPVNWVVRRTAYSHFCAGGTIEEAKATLLRTSELGLRSILDYSVEDAMDAATCDKNLAGNLETLRHVAALPRHCSSHSVVKITSFVPLPVLERASALLRWQHQHPSVDLPWKRPSFPVLAPGSILPAQAEPAPLSPEEVQSLEECLERLRAVCRACHDLHLPLLIDAEYFSVQPAIDYLAGVAALEFNHDFPLVVNTFQCYLKDTLPRLQLAIQAARSANVGFAAKLVRGAYIVKETQRAAAGSYETPIQAGIEATHANYDRCARLMLETAAKSAKSNAVVLASHNAASVRRAISTADALGLARKDERLQFAQLKGMADALSLAIGQAGYLCSKLHPFGSLEDTSEWRAPLWYSLTTGQLGMADGLSLALARSGFNASKLIPFASLDAVMPYLIRRAQENKGMLMQAGTDRARLQHELLRRVGSTLGLA
The following text describes a protein:
Function:
Essential fertilization factor required for male fertility. Part of a conserved trimeric sperm complex with the essential fertilization factors IZUMO1 and SPACA6 which bridges sperm and oocyte membranes during fertilization by binding to IZUMO1R/JUNO on the oocyte.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKVLATSFVLGSLGLAFYLPLVVTTPKTLAIPEKLQEAVGKVIINATTCTVTCGLGYKEETVCEVGPDGVRRKCQTRRLECLTNWICGMLHFTILIGKEFELSCLSSDILEFGQEAFRFTWRLARGVISTDDEVFKPFQANSHFVKFKYAQEYDSGTYRCDVQLVKNLRLVKRLYFGLRVLPPNLVNLNFHQSLTEDQKLIDEGLEVNLDSYSKPHHPKWKKKVASALGIGIAIGVVGGVLVRIVLCALRGGLQQ
The following text describes a protein:
Function:
Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.
Subcellular Localization:
Nucleus.
Sequence:
MSSNNQESLANRSHTVTVSETSQILQLRANQTEQVPKLAKKEQKSKVRWDENVVDNEHMNKKKTKICCIFHPQQNFDDEDGGECEHASSSASSSSSSESENDTSMDFEARRQARIARRRQKLERKRSSSPNAYEYQPDYSQYRQKYLHGDK
The following text describes a protein:
Function:
Shows strong antibacterial activity against numerous Gram-positive bacteria. It selectively inhibits peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio) thus inhibiting cell wall synthesis. Shows antibacterial activity against the Gram-positive bacteria M.luteus, E.fecalis (MIC=32 mg/L), S.aureus (MIC=16 mg/L), S.carnosus (MIC=2 mg/L), S.pneumoniae (MIC=2 mg/L) and S.pyogenes (MIC=2 mg/L) and against a number of methicillin-resistant S.aureus and glycopeptide-intermediate S.aureus isolates. Does not show antibacterial activity against Gram-negative bacteria or antifungal activity against C.utilis. Shows slight antifungal activity against C.albicans.
Miscellaneous:
MISCELLANEOUS: During maggot debridement therapy which involves the controlled application of cultured sterile larvae to an infected chronic non-healing wound, one of the key factors which protects larvae against the infectious wound environment and contributes to wound healing through its antimicrobial activity.
Subcellular Localization:
Secreted. Host cell membrane.
Sequence:
MKFFMVFAVTFCLALSFVSQSLALPADDEAHFVDGLEALKTIEPELHGRYKRATCDLLSGTGVKHSACAAHCLLRGNRGGYCNGRAICVCRN
The following text describes a protein:
Function:
Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors. Cleaves more efficiently on assembled 50S ribosomal subunits. Cleavage is strongly stimulated by ribosomal protein L3 (RplC); 20-30% DMSO can replace RplC, suggesting RplC may alter rRNA conformation.
Subcellular Localization:
Cytoplasm.
Sequence:
MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPNDLHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYSTAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT
The following text describes a protein:
Function:
Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
Sequence:
MPYLDHAGSTLPSKIQLEEVAKQQSQLILANPHSHHATAVKTKQIVNSARLRILQYFNTTSDDYFVVLTNNTTHGLKIVAENFKFGQKTHSILNIASVLHGGSSNLGYLYDSHHSVVGLRHVVNGKVNSISCVNEESILEHEIPDVEHSLFVLTAMSNFCGKKYSLESVHRLQEKGWAVCLDAASFVSSSALDLSQQRPNFIAFSFYKIFGYPTGIGALLVRKDSAHLIEKTSFAGGTVQSVDEMSMFFVLREFERAFEEGTLNYYGIAQLQKGFEEIERCGGISSIRNLTHHLCKNALYMLKSKKHPNGRPVVEIYSQSEQFENPDKQGPIVAFNLKRPDGGYYGYTEVEKMCAIFGIELRTGCFCNIGACKKYLGITSEMIQENMSKGKRCGDEIDLINGTPTGAIRISFGRTSTEHDITALEQMIDTCFTEGEHQAQSKPDPMNIESYSPTVVNLFSFPIKSVGSVGRKRYELTARGFKNDREFLIVNDDVTLNLKTHPELCMLTATIVDDDQLLIQTFDQNENLVLPMSLSLKDNGAKLVCKNTIATMDCGDKVGKWLDNALDRQNCRLLRVAEDSKKNFVNDSPFLLINEASVYMLSRYINMEVREILTRFRSNIVVRGLPPFIEDTAKRLSIENLEFEVVDKCTRCEMICVDPMTGEKDPSLLLALRDYRNKQKMTFGIYIRQTNFESGQYLESGMSVNFSTD
The following text describes a protein:
Function:
Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability.
Miscellaneous:
MISCELLANEOUS: Present with 606 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus membrane; Multi-pass membrane protein.
Sequence:
MGSNDLINEAYDDSEVVGEERESKSAWMKRWYQLLTSPLDLQLVINEKLEMINWDAYAKSLAKPLGNFLTILFFIIRLLQDNLIKPNYYKLNVKSGAFDLSKSNKLKEFDYLWEISSSFQNNNQFYAFQSWYFVTLRFLNNLFRFTIFILLSLNLYVSCKFMFGYFKTYNLFHLKKEFNSPNLTKHNLKDLSKEYYEDIYKQSLWSMLKHFFRGSRDDGPHVNQNEDEIFFQLRKWIPTNFMINLFVSFSPTAIVFLSFSDVSFTSAIAIVFHQYILDYIITKRFQRSVDDDLILSSAALQEYEDKHIMARINQCSNIDTLSSAMGTRSKTPRIFTTHSLCGEEIREVYNYEKREFEALPKMTESVPGSRETRIKDYGGISQVSDHQSHPIGFHYSPRMSPYYRDKVLDNNLAQSSSNENLEKGGAYLPNQDQNRPSKSLSPLRKTPLSARQKRFEGSEFNVLNKNDINSILRSPKKKKNYHKR
The following text describes a protein:
Function:
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Sequence:
MKRRKAREYVLQFLYACEMNENTQKICNYNFLQEEIEKFWERNYEEQNSDIKSFANQLIEGTIEHIDIIDKIIQKYADKWNIERMITIDKNILRFSIYEILYRQDIPYQVTINEAVEIAKKYSTKESAAFINGILDRIAKEEICHNKSAEK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.
Domain:
The RING-type zinc finger domain is required for E3 ligase activity.
Sequence:
MALPAGPADAICALCQRAPREPVRADCGHRFCRACVVRFWAEEDGPFPCPECADDCWQRAVEPSRPPLSRRLLALEEAAAAPARDGPASEAALQLLCRADGDPLCSACRMAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVMDRRKKALTDYKKLRAFFVEEEEHFLQEAEKDEGASEDDELADPADRFRSLLQAVSELEKKHRNLGLSMLLQ
The following text describes a protein:
Function:
Bifunctional nuclease with both RNase and DNase activities. Involved in basal defense response. Participates in abscisic acid-derived callose deposition following infection by a necrotrophic pathogen.
Sequence:
METLQAVHHVVGVKVGGAGAVRSEVVECNSVQRCGTRVAFRGVSRRLRYEGAVWGGIGEARRVKKRSAVNAAYESSSGGNSHVEGGDNGGGNSTSEYLEAQVMDAVSMVPFHGKLLMTLGNGMEMEVDHINPAKGRLLYKSSTPTIFLKVTDGSNLMLPIVVGEAAVSMLMRALHDDEHASRPNYYVLMRDMVESLHYEPRMVRITDRVVDTYYARIYLGKPGEEELVSVDARPSDAINYAVRCKVPIYVNSSIIRADAVRPVTEVELTRRVELNIPRKRSSILAESFNSYEPDVFQDEMAMVMCMLVAAKQERYGDAIRWRDELARLRAEFKQKLRRL
The following text describes a protein:
Function:
Increases short-range diffusion of the wingless/wg protein, enhancing its signaling and expression of target genes required for wing margin morphogenesis. May act as a serine protease inhibitor since it possess the Kazal serine protease inhibitor signature (Probable).
Miscellaneous:
MISCELLANEOUS: The name 'pegasus' comes from the mythical winged horse able to carry Greek heroes over long distances.
Subcellular Localization:
Secreted.
Sequence:
MKLSAVLLAIALLALSLVQCLGLPDPSTKCVMECDTQEYRSICAADDKGSTKTYRNLCVMKTENCLQNANFQKISDKECP
The following text describes a protein:
Function:
Positive regulation of hypersensitive response genes involved in plant pathogenicity and partly of its own synthesis in minimal medium.
Sequence:
MLGNIYFALASGLAARERLPEYANAVFAADFDRAYQLVDHHSSQRGKSDDYAGVLAMADASLLLECDEEAEEGFRLAQRLIRHSDDQLRVVSCRNTGWQALLRDRYAAAASCFSRMAEDDGATWTQQVEGLIGLALVHHQLGQQDASDDALRAAREAADGRSDRGWLATIDLIIYEFAVQAGIRCSNRLLEHAFWQSAEMGATLLANHGGRNGWTPTVSQGVPMPALIQRRAEYLSLLRRMADGDRAAIDPLMATLNHSRKLGSRLLMQTKVEVVLAALSGEQYDVAGRVFDQICNRETTYGARRWNFDFLYCRAKMAAQRGDAAGALKFYTTYMQDALRCLRTETVNVRRASAAVPVASRASDDVSARLSAKYRRAYRYIIENIERSDLTTREVAAHINVTERALQLAFKSAVGMSPSSVIRRMRLEGIRSDLLDSERNPSNIIDTASRWGIRSRSALVKGYRKQFNEAPSETIWR
The following text describes a protein:
Function:
Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).
Sequence:
MHEIPFGEVLEKLRGLNAHRVLIQTPEGLKREAQELADFLEENGIEAIISGDINYGACDPADSEAKRLGCDALIHLGHSYMQLHLEVPTIFVPAFAKVDVVPALEKNLEEIRKLGKRIVLVTTAQHIHGLERAKEFLEKNGFEVLIGRGDSRVSWPGQVLGCNFSAAKVDADGVLFIGAGYFHPIGVAMAVKKPTLAINPYSGDAIWMDTEAERLVRKRWAQIAKAMDAQRFGVITSTKKGQLRLAEAKRVVKLLREYGKYARLLTMNHISYQALEGFDFDAYVVVACPRVPIDDYENWRKPVLTPREVEILLGLREDYEFDEILGAERREDEPIGISLRH
The following text describes a protein:
Function:
May glycosylate diterpenes or flavonols in leaves.
Sequence:
MANTVAELVFIPAPAVGHIMSTIEMAKVLLNRDQRLSINVLLISPPYPVPALTTYIESLAKNTIERIQFIELPKDQTPPKLDPKAFLTSLYEFYSSHCKHVRNIVADMINQTGSGRVVGFVVDVFCTGMIDVANEFNLPTYVFFTSSSAFLGFNLYIETLCVDHNQDHVMELSNSGGEMVVPSFVNPVPKKAFPAMYEIQDGLDMLINSFRELRKAKGIMVNTFLELETHAMKSFTDTNFPPVYPVGPLLNLDGVAGKADDMDVIKWLDSQPPLSVVVLCFGSMGSFSEVQVKEIALGLEQSGHRFVWSLCLTPSKEQLLDDPRELLPDGFLERTVGIGKVIGWAPQVSLLSHEAVGGFVSHCGWNSMLESLWFGVPTATWPMYAEQQLNAFEMVVELGLAIDLKMDYKIDMFNPAAIVVVTAEEIENGITRLMEDNNVRAKVKEISKLSRVTVAEGGSSYALVDYLVQEIMSNII
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MATEPKAAAENVKIDLFEDDDEFEINEEWEDRAEEKVAEQWEDDWDDDDVHDDFSQQLRKELENNIKKS