lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (By similarity). Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (By similarity). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (By similarity). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MALRGFCSADGSDPFWEWDVSWNTSNPDFTKCFQNTVLVWVPCCYLWLCFPFYFLYLSRHDRGYIQMTYLNKTKTALGFVLWIVCWADLFYSFWERSWGKILAPVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLIALLCALAILRSKIMTALKEDAEIDVFRDVTFYIYFSLVLIQLVLSCFSDRPPLFSETIHDLNPCPESSASFLSRVTFWWITGLMVRGYRQPLESTDLWSLNKEDTSEQVVPVLVKNWKKECAKSKRQQRKITYSSKDPAKPKGGSQVDVNEEAEVLIVKTPQKEREPSLFKVLYKTFGPYFLMSFLFKALHDLMMFAGPEILKLLINFVNDKKAPDWQGYLYTALLFICACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVYVTVDKNNILDAQKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGANSITVKNATFTWARSDPPTLSGITFSIPEGSLVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGRQLQERYYKAVIEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYCDSDIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRLLVTHSISYLPQVDVIIVMTGGKISEMGSYQELLARDGAFAEFLRTYASGDQEQAEQDDGLTGVSSPGKEVKQMENGMLVTDVAGKQLQRQLSNSSSYSGDVSRHHTSTAELQKAGPKNEDAWKLVEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFLCNHVASLVSNYWLSLWTDDPIVNGTQEHTKIRLSVYGALGISQGITVFGYSMAVSIGGIFASRRLHVDLLQNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFNVIGACIIILLATPIASIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFSVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQEMAPPSTWPQVGRVEFRDYGLRYRENLDLVLKHINITINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDDINIAKIGLHDLRVKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSGLPDKLNQECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFDDCTVLTIAHRLNTIMDYTRVIVLDKGEIRECGQPSDLLQQRGLFYSMAKDAGLV
The following text describes a protein:
Function:
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
Subcellular Localization:
Postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction.
Sequence:
MRERSQDSQAGLTLYVGLFGHLGMLHRTKYSRFRNESITSLDEGSPGGSVGNKGSSPPPYPALAPHLPTEDATVSSQESPTALCTLIPRMASMKLANPITFLGLKTFCLGTKQVSRLKLQENQDQTPSRPASPESNLNRTGPAPAPDPDQVGRRPTSLRPDTCPLPGPGEPSPRSKQDGPPLQHLLGNGLNYCVRYMGCIEVLQSMRSLDFGMRTQVTREAISRLCEAVPGAHGAIKKRKAPVKFLTTVLGKSNLQFSGMNIKLTVSTSSLTLMNLDNQQIIANHQMQSISFASGGDPDTTDYVAYVAKDPVNQRACHILECRSGMAQDVISTIGQAFELRFKQYLKNPSLNTWEREEVLVDGAPEDRDHDYYNSIPGKQPPEGGISDVRIQAQATDQMAYCPIRCEKLCYLPGNSTCSGVYKNCMGRSRPIGIPHERAGQGDTPSLRHFWRVDLFDDPCYVNTQALQSMHSYAGNQSSALPQGSPWHLGKAPETVQPGATAKPGSALALPHIRQQLWDEECFHGKLSRGAAEKLLVKDGDFLVRESVTSPGQFVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIKYHMDNNLPIISSGSEVRLKQPIRKYDNTGLLPPKK
The following text describes a protein:
Function:
May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate (By similarity). In vitro has 8-oxo-dGTPase activity.
Miscellaneous:
MISCELLANEOUS: There are 4 mutT paralogs in M.tuberculosis; the exact function of each is unknown.
Sequence:
MLNQIVVAGAIVRGCTVLVAQRVRPPELAGRWELPGGKVAAGETERAALARELAEELGLEVADLAVGDRVGDDIALNGTTTLRAYRVHLLGGEPRARDHRALCWVTAAELHDVDWVPADRGWIADLARTLNGSAADVHRRC
The following text describes a protein:
Function:
[Isoform KNATM-B]: Transcriptional regulator involved in leaf proximal/distal patterning. May act by sequestering BELL transcription factors.
Subcellular Localization:
[Isoform KNATM-B]: Cytoplasm. Nucleus.
Domain:
[Isoform KNATM-B]: The MEINOX domain (33-138) is sufficient for interactions with BELL proteins. The BP-interacting domain (BPID, 1-32) is necessary for interactions with KNOX proteins.
Sequence:
MDVKKDENSILENMKQEINHSLKEEAQEEEEILKKRISSHPLYGLLLHSHLNCLKVCSGDFDSPEIMNTADDLALSKLSLHPDSSSEATSSELDQFMVLFFFSPCQNIFTQQKTTFHVLLFFPLQINLTFKYSKFILPRKKQ
The following text describes a protein:
Function:
Responsible for the cyclization of trans,trans-farnesyl diphosphate (FPP) to (+)-delta cadinene.
Sequence:
MAPASQPLSHPKPISLQEEQRRSANYHPSIWDPSVIKSFTTPYTYEFHGTKLEELKQETDKLFASTKDTAALLKLIDSLRRLGAAYHFQKQIAEALTQLHVDRNVSINDLSTAALYFRLLREHGYRVSADIFEKFKGGDGKFMDSLSGDVEGLLCLDEASFLGVQGEKILEQAKGFASESLKTLIGKLDKNKAKHVQQSLEVPLYWRMERIEARNFIDSYQMDDTKSSVLLELAKLDYNLIQSAYQQELKELAEWWRELNFKEKLSFSRDRLMEIYFWATGLSFEPQYSKCRICFTKYACLATVVDDIYDIYGSLDELESFTKAVTGWDVKAVEELPEYMRVMFSAISEFTNELARETSKDHGLDVLPYIHEQWAILCRAHITEARWFYGGHTPTFDEYIQNGWISIGSLGGLVLLCFVEADSIVEQFPHCLKDYSQLFYWSSLITRLSDDLGTSKAEMERGDIPKAVQSYVIEKGVSEEEARDHVKNLISDSWKKINEEIVDNTFPEVIVNLSKNMARTAQCMYQHGDGVGTSTGVTKDCIVSSILKPISI
The following text describes a protein:
Function:
Gibberellin-regulated protein that may function in hormonal controlled steps of development such as seed germination, flowering and seed maturation.
Subcellular Localization:
Secreted.
Sequence:
MAIFRSTLVLLLILFCLTTFELHVHAAEDSQVGEGVVKIDCGGRCKGRCSKSSRPNLCLRACNSCCYRCNCVPPGTAGNHHLCPCYASITTRGGRLKCP
The following text describes a protein:
Function:
Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth. Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein.
Sequence:
MQNYKYDKAIAPDSKNGGSPALSSSPRRGGSKRALLVCLDLFCLFMAGLPFLIIETSTIKPYHRGFYCNDESIKYPLKTGETINDAVLCAVGIVIAILAIITGEFYRIYYLKEKSRSTVQNPYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSEGYIQNYKCRGDDSKVQEARKSFFSGHASFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIDVGKAEDILCLCPREATLGEETSKNPNVKESSVMTTSSRESGVQREGDTSKDTQWWNRNQIPSLLILSQKTKIVFFVSDLFKTKTTLSLPPPAIRKEILSPVDIIDRNNHHNMV
The following text describes a protein:
Function:
Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation. Acts via its association with eiF5a (eif5a and eif5a2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation. Plays a key role in ribosome hibernation in the mature egg by preventing mRNA translation, leading to ribosome inactivation. Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the egg and early embryo.
Sequence:
MVQLSKTGVRDTLKAGHPPAVKAGGKRVVKKSADENANVEKETRKTDKPRSVLAPSRMQHLSLLLSGPLEKLGHDFPETPVSVRHSRVRPSVEKPHISRIPCIQQPRKF
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
Subcellular Localization:
Nucleus.
Sequence:
MKLNELAANPKIADGVGIDQNSEVSINQETKEKEHKDTSCETSNEEYEDLSEYEEVEEDLSEDTQDEGNRSKGEEECVHSINEDSSIEVVEEEYVEEEYTEGEEYSDVEYIEEVIEEVIEEEESVDEVLDKKEMTSKKSEEGKEVSMSGVIQSNSCERKRKTGVELINSHTQNKVQKMPPKTKSELDSKERKVSDSCMKKKSRWDSQSKDHSSIGGNENKPNKKKSRWDRVEDQEKITSTASLGDYDDFLKLKQQLIEIDLKLHRLEGSQGNEAKNIRVKLQKQRAEIATNLFVDKNHQILIQNEKILSRKLQKKIYVPTKEYPEFNFIGLILGPRGNNLKRMERETKTRIFLRGQGSVLGVKNAENKKKNAVPSDCDNDDLHVVIEAHDQKSLDAGSEMVEKLLVPPEESSQLKMSQLRELAMLNGMERSDSCQVCGDTEHFTSFCPLTDKCSNFLSDVSGGGFPISSNSNIFSEIKSAAGTLSSSTIDPSNVYVGYLPQSVDDAGLNQLFRPFGAITSARIVKDHITGLSKSYGFVKYRNPTNAAKAVEKMNGMSIEGKTIAVRIAHHSPIPSVISQGAYSSRPIPEPIPGAVGLFGPPPSGPPITPGSNGSLSQNENNFTRPGYSISHGFPCNFPASSRGSLRSYLPQTSDIFTSASSTAPTASELANFSGNPANFNSNFLLNNSYSQRNLFSSEKSQRLLLDTKFSNLSNSRDHRTLTYHSPQVSQSLVVPTSEETTNFPGNPDYVSLNLSRQKSGLS
The following text describes a protein:
Function:
Involved in mRNA splicing and G2/M transition.
Subcellular Localization:
Nucleus.
Sequence:
MDTFPSLFLYSLTIQNSNYVQSSCAASLSGKKAQEIVIATESRLLIYKVDATDGRMNCILNQNCFGIIRNVAPLRLTGFKRDYLVVTSDSGRITILEYNVEKNKLVPIYQETFGKSGIRRVVPGEYLAIDAKGRAAMIASVEKNKLVYVLNRDSEANLTISSPLEAHKANNICFHLIGLDTGYANPIFAALEVDYSEIDHDSTREAFTSSEKVLSYYELDLGLNHVVKRWSKVVDRNSYMLIPVPGGNDGPSGTLVISNGWISYRHLQKAFHQIPILRRQAASANAISTPWNQVNSNSANDGPLIVSAVLHKMKGSFFYLLQTGDGDLLKLTIEHDGQGNVVELRLKYFDTVPLAVQLNILKTGFLFVATEFGNHQLYQFENLGIDDDELEITSLDFQAQDNEVGTKNVHFGVRGLQNLSLVEEIPSLYSLTDTLLMKAPSSGEANQLYTVCGRGSNSSLRQLRRGLETTEIVASELPGAPIAIWTLKLNQTDVYDSYIILSFTNGTLVLSIGETVEEISDSGFLSSVSTLNARQMGRDSLVQIHPKGIRYIRANKQTSEWKLPQDVYVVQSAINDMQIVVALSNGELVYFEMSDDVEGGQLNEYQERKTLTANVTSLALGPVQEGSRRSNFMCLACDDATVRVLSLDLYTTLENLSVQALSSPANSLCIIPMNVNGVSTLYLHIGLMNGVYLRTVIDVTSGQLLDTRTRFLGPRAVKIYPITMKNQNTVLAVSSRTFLAYSYQQNLQLSPIAYSAIDHASSFASEQCPEGIVAIQKNTLKIFTVDSLQDDLKSDIYPLICTPRKIVKHPNFPVLYILQSERNFDSFKYAQENGDVGSSYTKEKQNEHTSKSWVSFISVFDMISKKIIHESPLGDNEAAFSMTAAFFKNRDEFFLVAGSATNMDLECRTCSHGNFRVYRFHDEGKKLELISHTEIDGIPMALTPFQGRMLAGVGRFLRIYDLGNKKMLRKGELSAVPLFITHITVQASRIVVADSQYSVRFVVYKPEDNHLLTFADDTIHRWTTTNVLVDYDTLAGGDKFGNIWLLRCPEHVSKLADEENSESKLIHEKPFLNSTPHKLDLMAHFFTNDIPTSLQKVQLVEGAREVLLWTGLLGTVGVFTPFINQEDVRFFQQLEFLLRKECPPLAGRDHLAYRSYYAPVKCVIDGDLCEMYYSLPHPVQEMIANELDRTIAEVSKKIEDFRVRSF
The following text describes a protein:
Function:
Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry.
Subcellular Localization:
Nucleus.
Domain:
The FM region is required for binding smad2/smad4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated smad2 that is in an activated smad complex (By similarity).
Sequence:
MTKHWGGPGLLAPPVITVGEGAQRDHHLDCRIGYSSSKRSCHRSSNPLLELGGRLDKSTGMAQDSCYRAKATNQGPWELQDGNSSGGKKKNYQRYPKPPYSYLAMIAMVIQNSPEKKLTLSEILKEISTLFPFFKGNYKGWRDSVRHNLSSYDCFVKVLKDPGKPQGKGNFWTVEVNRIPLELLKRQNTAVSRQDETIFAQDLAPYIFQGYSQPNKSKPLPPESSLPPVPTRQSPPPSEDPYRPKLDSTFAIDSLLHSLRPASSAGEGLRERESWGVGPPPHTRSTTPPRPCNASYNGSSSASSVSPASDFSDEDWRGVTVVGKRSGDRGITSDAYSDSCPPPNKSSKRGNTPPWELPTSYAKYTPPNAVAPPSMRFNGNPFMPLGGIPFYGYGGAHVTTSHLIGHPYWPILPSGPVSIQAPPLLMDLDSMLQSVPPNKSVFDALGSNNQTVHPSPNQYALQNGPSLCKYSL
The following text describes a protein:
Function:
Interacts with eme-1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAGDTGANPLFLGWVKEWWDTAREHNTKGAPTYKKAYNSLKACPLTFQHPSELQVLNGFGPTISQRLTDRLKQYCEENGLPMPKHPKRKRTLELESALAAAGAVQDEQPPPPKRARTARPYVPKLNSGAYALLMALSELGPKEFMDKTTLIAKAQPYSEHSFTVPTMANKSYTAWDSMKTLEQKELVWLRGLPSKRYSLTDEGWEVVKRMKEAQNLVDGVAGSANTSRNAIASGSGTSNPNRSENVNPNRQDSGVKRESRYTPLDLKPFVTTTATPERPLQPKPHTANSEYSIIIDSDDEDPKYDEEDRKPIIRDTTNRDYIDLVADGDSVPDESNLPHFTPIRLAPGSFTVELVLDTREVQAKNNRDHIQEELSKLGVRPVMRSLELGDVLWIAKCKQPGWLNRLGAEGDEVVLDYIVERKRLDDLIGSIKDGRFREQKYRLKRSGMKNVVYIIENYNIDMDIRRQYQDAMDTAMASIQVVNGYFLKKTDTIAESIRYLAAVTYMLKEIYESKPLFVIPTQVLTAKNYLPLVKHLREKEPSRGYYISYPAFASLVSKSEMMTLKDVFIKMLMCIRRLSGEKAIEIQKVWKTPYQLVKAFEACGSDENGKKKQKVLVMSMLSHLVDRRNVDKGLSERIADVWGFL
The following text describes a protein:
Function:
May catalyze the production of the insect juvenile hormone methyl farnesoate (MeFA) to trigger defense against insect herbivory.
Sequence:
MSTSFTMIGGEGPNSYREHSKYQGALVIAAKEKINEAISTKLDIDFTSNLVNIADFGCSSGPNTFTAVQTLIDAVENKYKKESNIEGIEFQVFFNDSSNNDFNTLFKTLPPARLYFASGVPGSFFGRVLPKNSLHVGVSSYSLHFVSKVPKEIKDRDSLVWNKDIHCSGSSKEVVKLYLGQYKIDVGSFLTARAQELVSGGLLLLLGSCRPTGVQMFETVEGMMIDFIGSSLNEIANQGLIDQQKLDTFKLPIYAPNVDELKQIIEDNKCFTIEAFEKISHAKGEYPLDPEYLTSAFKVTVGGSVASLFGQDGMEKTYELVKEKTQEMLPQIAKAKPGMQYLIVLRRN
The following text describes a protein:
Function:
Required for the formation of intervein tissue of the wing. Acts in a dosage-dependent manner to suppress wing vein formation and promote development of intervein cells. Might play a role in the proper formation and maintenance of the trachea.
Subcellular Localization:
Nucleus.
Sequence:
MDPTRGDSRYNLNYSMSSIGLSLADPADMYGNPALGAGRPPSGGLLQNMGGVPPMQRPNPAAGAPPAPQCQTLHSPQHASQQQQQQQQQQQQHQQQQQQQQQHPQQQRGLKRSGSDCYEDHHRSSGGLTLQGLDNVASGAVDDSVDNYNPLPNKKSPPANGKKTKGRVKIKMEYIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVMLLVASETGHVYTFATRKLQPMITSEAGKQLIQTCLNSPDPPSVGGGDQRMSATGFEETELSYNIADEDSKDDRSPTSSGNESDDSSDVEMPAEAAEVATKLPASKTEVSAPPAASCSAATASSGHKTMPALNYQTDTNSGPSTSTAAGGGGSADSKYVYSAASIANIPQKMLRQLIQSGHLQVHAEEDGNQYVTIPLSSTAANLIKSNKLTASGSGASGSGTPVKNDASADKPLTIKQEFD
The following text describes a protein:
Function:
DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MAQMVAGDQDAGTLWVPSQSESQTESDISTQSLRKPTMSYVILKTLADKRVHNCVSLATLKKAVSITGYNMTHNTWRFKRVLQNLLDKGMIMHVTCCKGASGSLCLCKERALKSNHRAKRCQDRQKSQKPQKPGQRESEPCQLLLSSKKKNDQLFKGVRRVAKGNRHCHY
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MDSINFDINNALKHYMDDPASIPTPEADSALVDCENEPESLGDNGLINSILNPIVDAVAENPDAITRAHIFDSLQFLLKYTSFLSAHALSKIFDLITSGLAAEADVVHHDLEAEEQELLAHHKQLLDIYAFLLQWTIAGVEAKAAEKASNTVTTRGRGKPKKPTGRDGTWDSSAQLETALNTMVKALRLKLARIFMTTSERDTFIGLLTRPVYMILESEQRTKNTSIRMHCWKVLCVAIKHHGHGYAAQISIVQNLTYFEHLAEPMAEFLHILAEQYDYPQLAEEILRELSNKEFNSNDNKGPKSVSTFMIKLSELAPRIIIKQVTLLAKQLDSESYTLRCALIEVFGNMLIHLSKSAERGENHKTQMNAFFDVLEERFLDINPYCRVRAIQVYIKLCELEQKFPKRRQKAAELACRSLEDKSSHVRRNAIKLLGTLIRTHPFTALHGAQLARKDWQERLGKVEEELNALKPPVDAPGLDGEAGNTSVDPALLDDATQMMESPRKQPSEMTEEEKIAAIRRAQEEAATSEAIEKLTLTKRYYSEALKFIDVLHEATETVCQLLGSKNKSEVIEAMDYFEIGDAYNIEQNKIGIRRMLRLIWTKGNSDEGKGVQTHLIECYKRLFFEAPGNFNANDAATYIARNMISLTFGATPAELTSLEQLLSTMMKSGMISDLVIAKLWQVYGVQKREISRTQRRGAIIVLGMLATANPEIVVGEMETMLRTGLGAHGRADLQLAKYTCVALRRINPTGRQSKDSGIKFSRLPNDHALLIKLAAITEVPTDSKEWYGVAEQAINAIYAIAKHPDVLCSEIIRRKTKGVFARPPKSRSASHEEKPSPTESAEPTPAEEPNPDAMDEDEPTSAQAPVATQPEDAEAKKQHREHAIALSQLLFIVGHVAIKQIVHLELCELDFKRRKQEKEKAAGTTSKRTSLSASASTNRRKSGGPKAAKDEEEQDELDLIGGTTEDDFTEAIFHIRERELLYGPQSLLAMFGPMVSEICANNTTYRNRELQQAATLCLAKLMCVSSEYCEANLPLLITIMERSVDPTVRSNAVIALGDMAVCFNHLIDENTDFLYRRLSDPDPSVKRTCLMTLTFLILAGQVKVKGQLASMALCLEDGDKRIADLARMFFTELSTKDNAVYNHFVDMFSLLSSDPSLEEEGFRRVVKFLLGFVEKDRHAKQLAEKLAARLQRCDTERQWNDVAFALGLLQHKNEEIAKVVSEGFKVVPSGQQGMQATQRATQATQARA
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Sequence:
MSLGKRQADDSHFRSFLIQHTDIMILRCMARRPGAVQSLASASRQTPSFVRTAYTVPTLDKHVEMQKNGVPGLFTPKGFNTAYTEYQKYMIDELNESTAAWAFINQLILPGPSTRNPRDPVQSPSPEAREPSIGKHFSSLENFCARPLWRRQKAMFGPGFVWLVQTNDAQLGSLRILPTYLAGSPLAGAHYRRQSHDLNTHNADSYQALNTVGTFGSAAKQNLQPKKPLGGVDVVPLLCVNTWEHAWLHDYGVRGKRQYLEAWWDKIDWNWVRQNATMQTQQKWQF
The following text describes a protein:
Function:
Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity).
Subcellular Localization:
Mitochondrion outer membrane.
Sequence:
MEMQLGAMLYVYKGEYGLPSIDFECLRALCLLRFTRCPMDVQTSSNPLRSGAGKLPYLQIGNQKFAGYRQIKRVLDLEGYPIDAHLSTKQKHLSTAYANWVFTNLHAYYHYFLFGEPHNFDTTTRGLYAKRTPFPFNFYYPSSYQREACDVVQVMAGFDVNDKLDKHEGDYLVVNAKKVVNLLSRKLGRKVWFFGDTYSEFDAIVYSYLAIIFKIALPNNPLQNHIKGCQNLVNFINRITKDIFRIEGYSSVKLTKTPSGTEASLTASERKFLDSELNTKIVAGVGAVLAMGAFAAWRGIYNQLTTRSSTDYDGIDYEDDEMEEGLD
The following text describes a protein:
Function:
Esterase that catalyzes the hydrolysis of p-nitrophenyl esters of acyl chain lengths C4-C10 and Tween detergents. Also has a pronounced thioesterase activity towards palmitoyl-coenzyme A.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Domain:
Contains a C-terminal autotransporter domain that integrates into the outer membrane and enables the translocation of the catalytic N-terminal domain to the bacterial cell surface.
Sequence:
MRKAPLLRFTLASLALACSQALAGPSPYSTLIVFGDSLADAGQFPDLVGGTPGARFTNRDADGNFAPVSPMILGGRLGVAPGDLNPSTSVGIQPDGNNWAVGGYTTQQILDSITTTSETVIPPGNPNAGLVLRERPGYLANGLRADPNALYYLTGGGNDFLQGLVNSPADAVAAGARLAASAQALQQGGARYIMVWLLPDLGQTPNFSGTPQQNPLSLLSAAFNQSLISQLGQIDAQIIPLNIPLLLSEALASPSQFGLASDQNLVGTCYSGDSCVENPVYGINGTTPDPTKLLFNDSVHPTIAGQQLIADYAYSILAAPWELTLLPEMAHASLRAHQDELRNQWQTPWQAVGQWQAFVASGAQDLDFDGQHSAASGDGRGYNLTVGGSYRLNDAWRLGLAGGANRQKLEAGEQDSDYKLNSYMASAFAQYRQDRWWADAALTAGHLDYSDLKRTFALGVNDRSEKGDTDGEAWAMSGRLGYNLAADTSNWQLAPFISADYARVKVDGYDEKSGRSTALGFDDQERTSRRLGVGLLGSVQVLPSTRLFAEVAQEHEFEDDEQDVTMHLTSLPANDFTLTGYTPHSDLTRASLGVSHELVAGVHLRGNYNWRKSDELTQQGISVGVSVDF
The following text describes a protein:
Function:
Involved in the lipid remodeling steps of GPI-anchor maturation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MCGRQMLRQCLLLVVLVSSLVLVCESSDGDERPSYRECVKVCEQTGCVDGQCYNSCNFPVNVDLEGNILPKKAQLNSPHEKFLEEPLYLRWKKWDCISECRYQCMLREEAGSEFPVKYHGKWPFVRIFSLQFLRTNYIILRTPVHAGSKGTYHLRGLCDPRDMTFTEMLDYSSAVALIGYSLMLAIIRTLNLRAEAPRVMVAAPIIAFITTHILYLNLYKFDYGVAQLLIWSTWGFISRHPARFKLWGVVFGAAFAMLLEIFDFPPLWGIFDAHAMWHAATLPITYLWWSFIKDDAIFRTEMLVKKSQSASDPFAESESRKTQ
The following text describes a protein:
Function:
Involved in fatty acylation of protoxin at internal lysine residues, thereby converting it to the active toxin.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKKINGFEVLGEVAWLWASSPLHRKWPLSLLAINVLPAIESNQYVLLKRDGFPIAFCSWANLNLENEIKYLDDVASLVADDWTSGDRRWFIDWIAPFGDSAALYKHMRDNFPNELFRAIRVDPDSRVGKISEFHGGKIDKKLASKIFQQYHFELMSELKNKQNFKFSLVNS
The following text describes a protein:
Function:
May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.
Subcellular Localization:
Cytoplasm. Early endosome membrane; Peripheral membrane protein.
Sequence:
MDSYFKAAVSDLDRLLDDFEQNPDEQDYLQDAQKAYDSKHYSVSSELTASQVTSLLPKDQQCINCCVSSETGYETNQIALSEKGLGGLTSLQNEKNVTGLDLLSSVDGGTSDEIQPLYMGRCSKPVCDLISDMGNLVHVANSEEDIKKLLPDDLKSSADSLTGLDLSSVSETFCVSSADHGNNAVREEQNDVSLELQNRGISGTTEFGVKVDRALSDSCNYNEKENLEDKKISNQSEPVADFNMPSALTQQSSKAFDAKDHPQHKNQPCELVKAVGCLVKEEEEVPVKAATECLKEGGSTSALSCSLPKDGGLCLNDPNLRDENSKLPDFSFEEDRTAVFIKESAKEDSRNVDLNDNKDVIQDSASALHVSSENTYSSLSCLPVPGSLCGSLIDSKGHGGFLPQNENKDNVQDAVTVHEEIQKKVTSGGESFKETDLLKQDKCKNILHQPLTEKMGDRKVDSNQMVIRVESMDYVDNSSSYTAAESQIELSGASAPESPDHCEGLTFSSNDIDGQDLDYFNIDEGMKSGAPISDAELDAFLTEQYLQTSNIKSFEENINDAKPQMNQIDMKGLDDGNIDNIYFDAEAGATRESPGINMICETIDKQNTAENGSLSLSEKSTVTVEQGLSSSKSEITNELSTSDSNSQSVHVGGARPKQLFSVPSRTRSSKEPNKLDVPNMPESKPRTANTIVATTCTTDSVTDPQVSFDSNYIDIESNFEGGSSFVTANEESLPTNTCKDGLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYLEKEARVCVVCYETISKAQAFERMMSPTGSNLKSNHSDECATVQPLQETQTSSIPSPTTLPISALKQPSVEGLCSKEQKRVWFADGILPNGEVADTTKLSSGSKRCSEDFSPLLPDMPLMVNTVDHAHSTPVEKPNSETEDTRNEIIQSPTSQVPPVEKLPTNTGTEGLPTSASFTLDDDVFAETEEPSGPTDVLVNSSLPVASTSDYRLLCSIDNVCNKMSLLPDDEDSLPPLLVTSGEKGSVPVVEKHPSHEQIILLLEGEGSCPVTFVLNANLLVNVKLAFYSSDKYWYFSTNGLHGLGQAEIIILLLCLPNEDTIPKDIFRLFITIYKDALKGKYIENLDSITFTESFLSSKDHGGFLFITPTFQKLDDLLLPSNPFLCGILIQKLEIPWAKVFPMRLMLRLGAEYKAYPAPLTSIRGRKPLFGDIGHTIMNLLVDLRNYQYTLHNIDQLLIHMEMGKSCIKIPRKKYSDVMKVINSSNEHVISIGASFSTEADSHLVCIQNDGVYQTQANSATGHPRKVTGASFVVFNGALKASSGFLAKSSIVEDGLMVQITPETMDGLRLALREQKDFKITCGKVDAVDMREYVDICWVDSEEKGNKGVISSVDGMSLQGFPSEKIKLEADFETDEKIVKCTEVFCFLKDQDLSISATRYQFAKEIAMACSAALCPHLKILKSSGMNKIGLRVSIDTDMVEFQAGSEGRLLPQHYLNDLDSALIPVIHGGTSNSTSLPLEIELVFFIIENLFE
The following text describes a protein:
Function:
Transcription factor. Binds to the sequence 5'-TGATAA-3' in regulatory elements of target genes, such as lin-39. Involved in embryonic development and in vulval development in larvae, acting redundantly, at least in part, with egl-18. Perhaps acting together with egl-18, may form a positive feedback loop to initiate and maintain lin-39 gene expression to ensure proper vulval precursor cell (VPC) fate specification. Together with egl-18, acts as a downstream target of the Wnt/beta-catenin asymmetry pathway, required to adopt or maintain the seam cell fate. Required in seam cells, acting redundantly with egl-18, to promote production of alae, expression of several seam-specific genes and maintenance of seam cells in an unfused state. Plays a role in longevity. May form a transcriptional circuit with GATA factors egl-18 and elt-3.
Subcellular Localization:
Nucleus.
Sequence:
MTSSKEEMPDEMVSREVEEEMEDRVEETATTAAACTGCAQLHKDIRQDVSKMMSKIDEVCGRLEALISEKEKVLLEQMSESGSEEKYPPSPTESRASPSSVGKSNGGCRKRKPTKESVNRHLENGGSDSPFEKITRNISTPVSASSPFPDFQNFNGFVFDPMANPQNMMNLLNLVQQQQHQAAAHHHAQQQAREQKPVKAEESKQQEPSENRNQSPSASVEQTLLDQLSMQFNGKSPSPTVHASTAAAAGSSEDDTSANSSISKCSNCSTIKTTAWRRDLEGKLVCNACGLYYRLHRTHRPVHMRKDFIQQRFRRRMREDENPATSQAAVFSQLLGLPSMANGGANALTFLEQINQLNQSQEQRKSP
The following text describes a protein:
Function:
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MWQAFKNAFKIPELRDRIIFTFLALIVFRMGIYIPVPGLNLEAWGEIFRRIAETAGVAGILSFYDVFTGGALSRFSVFTMSVTPYITASIILQLLASVMPSLKEMLREGEEGRKKFAKYTRRLTLLIGGFQAFFVSFSLARSNPDMVAPGVNVLQFTVLSTMSMLAGTMFLLWLGERITEKGIGNGISILIFAGIVARYPSYIRQAYLGGLNLLEWIFLIAVALITIFGIILVQQAERRITIQYARRVTGRRVYGGASTYLPIKVNQGGVIPIIFASAIVSIPSAIASITNNETLKNLFRAGGFLYLLIYGLLVFFFTYFYSVVIFDPREISENIRKYGGYIPGLRPGRSTEQYLHRVLNRVTFIGAVFLVVIALLPYLVQGAIKVNVWIGGTSALIAVGVALDIIQQMETHMVMRHYEGFIKKGKIRGRR