lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MEAAMDLMRRMPPGSTEMALNALLSLLPDHSLDLLSQVDLPLQVCMDKENNKEYILCEYNRDADSYRSPWSNIYEPPLEDGTVPSDEMRNLEIEANEVFSVYRDQYYEGGVSSVYIWEDEDESFIACFLIKKDGQGKRGHMQIGSWDAIHVIQVGSEEEGAAHYCLNSTVMLSLTTDNMQSGMFNLSGSIRRQMSMTLAVADGHLVNMGKMIEEMEGKLRNSLDQVYFGKTREMVCSLRPPPEVLNMRLPDS
The following text describes a protein:
Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPQALERADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGVFLHCCICGAIIRPVATSVAPETKECPPPPPETPALGCLATCGRTIQRHLAFDILQHNTGYCVYILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIIPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFMGGSFYALQKKEQGKQAVAADALERDLFLEAKDGPGKQRSPEIMCQSSRQPRPAGVNKHLWGCPASSRTSHEWLLRPKAVLQAKQRALGWNSRT
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MFSQNPYESHVDVAVSAASANLRNMTNEQLISLLDDDALLESIIVNLPQVRSMPTDKESALAANKSLAEWNLAQKPRIDAAKTQTVDLYDQVKKLQGEVAVLKSQLDSVSSSKSLDTTSSLMQVAAQEADDDAEALFTQFENGEISVEIFLKQFKDKKTIAHLRKIKSDRLAALLREQTYSSYAQPTVPPPMPHAQPGYPTGNHMPGIGNIQFGSGYSGYPNISQPSAGRHPFF
The following text describes a protein:
Function:
Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays.
Subcellular Localization:
Cell junction, adherens junction. Cytoplasm, cytoskeleton. Apical cell membrane; Peripheral membrane protein. Note=Colocalizes with F-actin in stress fibers and adherens junctions.
Domain:
The ASD1 domain mediates F-actin binding; The ASD2 domain mediates the interaction with ROCK1 and is required for apical constriction induction.
Sequence:
MMQVSQGTIGSPWHQAYHSSSSTSDLSGYNHEFLRRSPDQYSSRGSMESLDQASAAYHHHLPPAKSTNCIDQLVHLHNKRDSAYSSFSTNASIPEYRSSPFSKERSYSMESMHSRNSSGQEGIKHADIKYIKTVYDVQRGISEEYEVNSSSVKNRNYSRQPAYNRHSIGPHGRLEQSRFFSESGGFERAAPMPPTRSDSYALTRHHERPNSWSSLDQNRNFRTPKAAGLHSTNTSSNAAQQPKHVHGDGHLHPVLERSPESSPLIKPKQVYSETPQPGQPMLPTGIYPVPAPEPHFAHAPQPPKNNNGRLYPALAKEGSYGAKSSEKVLPFSEPNKNEKDTQNLRSKSVGQYPMNHSVKEREKKQEGPTGFAHYKLHFTAGPDISTSSLTNDRNDQQPLRLDNIDINEQQKNGTKVAEEFSVYAHPAFQNEWSDSKTKQDIASSDIIGLHRNSLSSDAHGEHEYHNHFNIASSSHNKMDERSNRQADHRKKLESLSFTVHADEADGPSSNPLKPDESPSPSQKKSYDFTRRRLSSSSSQSSKTDGNKLSSVFDKVCKIEQREHENHRSQFLCGNINQSGLSTRGQNNKGSFTMVEEIRNKFISQDQTPNPNEWRRLSSSHSNEKVTGMHQLTRQGIVYGLQTGDAQKQMPEKQAEKMHSYNQEQNILQAVPDDDNRSFNSQTMPNKEDDWQCAAQDTLGFNRAYRNSVKDAQCKVLEATSYRRKDLEISPPHYKKPEKNVRPASAPFRKKSSSLSPHAPKERHSVTPTDNCASIQESQGVFFPSRIGAKRRITAEQKKRSYSEPEKMNEVGASESESAPLTVSKMEPVASFSENSVADRRRIFEREGKACSTINLSKPQLKQLQQNALADYIERKTGRRPSSQETRLLKERSQSTYFSGSIMDNQSMTSTSSMNSLNEHNLSYRHREPLSKTGRVSSTLPPGLTGFFDLSSFENNPEYPENRSRSSSFAHQLRSERLLDHRSKVEFGKGRETNKPKEVSLQSDDDVIITSSRRHGKSASAEDLLDRLPQPPALHVRSRSSPASDMKSREYMSRQEVGNKTSYASASNKEIRSIKSNHFEQMSFTPSFKNHIDTGEDPVPENSSTIQRSAQLENQRNTKTQSISGIYSPHPETKQEPLALPIHSVPAKVTQTSLAHATFDYITAEEYLYSGKRGKESASPTDNKEISDQEWCLPENSSSEDLNDPERFAKYTSAQRPQSFETKSGNSINETVQQNKSSGPTAGPKFSTSWKSNGMWSSGSSEAETTFNHGKISLHISESCLQPQSPMTGQEDEGDDEVFVKEQDTESFSGTFVPPSPPPFPPPSLEDALLKQRIEKFPLVPNTLDEIWENTEEASTQVKVKSNERYLQCASEYTASTESSGSYLLNSGITKRDTDGPLLRLSSIVPAPEPLASPVDPTKPIEEQETQPHGADTSILQSSEGNFNPSDSQSTLPHVRSELMSSEDAKSQELAKEIVTKDKSLANILDPDSRMKTTMDLMEGLFTKSSSALKEKNQKRKAKKQIDNIIAPESEXKEEKRETLDNASNYSAYYSTSAPKAELLRKMKTIHSQIGGKEEQFDVNEKKAELISSLTCKLEVLKDAKESLIDDIKLNNSLGEEVETQIETLCKPNEFDKYKMFIGDLDKVVNLLLSLSGRLARVENALSSLGEDASAEERKTWNEKKKQLCGQHEDARELKENLDRREKLVMDFLGNYLTGEEFAHYQHFVKMKSALLIEQRELDDKIKLGQEQLRCLTESLPSDYLISMKVSLPEERRSSLGNKSLPPPLTSSL
The following text describes a protein:
Function:
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Sequence:
MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHISFEELLKVFWENHDPTQGMRQGNDHGTQYRSAIYPTSAKQMEAALSSKENYQKVLSEHGFGPITTDIREGQTFFYAEDYHQQYLSKNPNGYCGLGGTGVSCPVGIKK
The following text describes a protein:
Function:
Involved in the glycerol metabolism. Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). GolD specifically uses NAD.
Subcellular Localization:
Cytoplasm.
Sequence:
MTFKGFDKDFNITDKVAVVTGAASGIGKAMAELFSEKGAYVVLLDIKEDVKDVAAQINPSRTLALQVDITKKENIEKVVAEIKKVYPKIDILANSAGVALLEKAEDLPEEYWDKTMELNLKGSFLMAQIIGREMIATGGGKIVNMASQASVIALDKHVAYCASKAAIVSMTQVLAMEWAPYNINVNAISPTVILTELGKKAWAGQVGEDMKKLIPAGRFGYPEEVAACALFLVSDAASLITGENLIIDGGYTIK
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and acts as a regulator of mTOR signaling.
Subcellular Localization:
Cytoplasm.
Sequence:
MALREDSSEDELQGQFSLLSATSFEVTDESEDTHGRSETGILDLSDEVFILILRRLDPTSLLRVGSTCRTLFRVCSCNSLWTKHFQTSFGVPFATAACSISAKSAFRLVFMWRTLFRNLHCNRSLQEKLFAEIPFPPHKYWVQWLVLEETVPLPSVRLPCTDIESLWGIEKEVLEGKVQEKDEDEGRMLKFEWKELYALALEHHGSIAKVFQHVLNQQSNDHCELEAMFSQYSQCRFQWLFTYWLFRQPAPFDRQLRAIYLQWQKHSKRKVVSWGGTLCDIRYLASLHHITSDYWRGKLAQGDETVGIQTVENYFSMCKSLVAWILGRDWGRLKSKKVYEDTLEGVYLLLRREMQETLVEHERFWQVAKVQMTRVCTLEETAVNYVNWKMIETLPYYKLYLVSGNMVYLDHVQGFLHRKRLVHDWFFMKENTWVRQLLPGDLYPLLEFDTKISQDSLHGDSMPAQLSRVMWLYLHSGQTLYLEAVKGLVLQCAQASLGHFCSLSPGASIQPHVS
The following text describes a protein:
Function:
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MMIHGFQSSHQDFSFGPWKLTASKTHIMKSADVEKLADELHMPSLPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRESKIANLMHVPPSLFTEPNEISQYLPIKEAVCEKLVFPERIDPNPVDSESAPSE
The following text describes a protein:
Function:
DNA-dependent ATPase (ssDNA stimulates the ATPase better than dsDNA) and ATP-dependent 5'-3' DNA helicase. Plays a role in an antioxidant pathway. Involved in DNA damage repair and/or recombination. Appears to move along DNA in single base steps, powered by hydrolysis of 1 molecule of ATP. Has low processivity, unwinds about 15-20 base pairs/second. Short (20 bp) substrates with 5'-overhangs or forked ends are the best substrates, is much less efficient on 52 or 76 bp substrates with 5'-overhangs. The presence of single-stranded DNA-binding protein (SSB) increases unwinding 4-5 fold. Has no activity on blunt DNA or DNA with 3'-overhangs. Requires at least 10 bases of 5'-ssDNA for helicase activity.
Miscellaneous:
MISCELLANEOUS: There are no RecB or RecC proteins in this organism; MISCELLANEOUS: In B.anthracis it is involved in mismatch repair, in B.subtilis it is involved in replication fork progression.
Sequence:
MSAALPAEPFRVSGGVNKVRFRSDTGFTVMSATLRNEQGEDPDATVIGVMPPLDVGDTFSAEVLMEEHREYGYQYRVVNMVLEAMPADLSEEGVAAYFEARVGGVGKVLAGRIAKTFGAAAFDLLEDDPQKFLQVPGITESTLHKMVSSWSQQGLERRLLAGLQGLGLTINQAQRAVKHFGADALDRLEKDLFTLTEVEGIGFLTADKLWQARGGALDDPRRLTAAAVYALQLAGTQAGHSFLPRSRAEKGVVHYTRVTPGQARLAVETAVELGRLSEDDSPLFAAEAAATGEGRIYLPHVLRAEKKLASLIRTLLATPPADGAGNDDWAVPKKARKGLSEEQASVLDQLAGHRLVVLTGGPGTGKSTTTKAVADLAESLGLEVGLCAPTGKAARRLGEVTGRTASTVHRLLGYGPQGFRHNHLEPAPYDLLIVDEVSMMGDALMLSLLAAVPPGARVLLVGDTDQLPPVDAGLPLLALAQAAPTIKLTQVYRQAAKNPIIQAAHGLLHGEAPAWGDKRLNLTEIEPDGGARRVALMVRELGGPGAVQVLTPMRKGPLGMDHLNYHLQALFNPGEGGVRIAEGEARPGDTVVQTKNDYNNEIFNGTLGMVLKAEGARLTVDFDGNVVELTGAELFNLQLGYALTVHRAQGSEWGTVLGVLHEAHMPMLSRNLVYTALTRARDRFFSAGSASAWQIAAARQREARNTALLERIRAH
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MIYSLCSDTIKKTETHTVVFLNGLLLSSHSLTTSHPPSLSPSTTDSSPSYLFAFLQEIEQSLASPASAQQQTVASPTAAAQQQQPQTLTGRFFRCLFADIFYSQLILISALVILLTLRGLLFTKSPNFHPKKWYTPLLSSVALSGLLSLSWQCLFLWNIAATAKATIILAPLLTFSVGIFLVIYGKTFVPGIGGPLILFSFAQAIHSWLFVTRRRREFTFTITALSTSVLPPRTRVIAVVSSILSVLYSSFLAAGIGGATATRKGLVDILFISLIMISLAWTMQVLKNVQVVAVSKAAYAHFANYDVINACDALFGNRYGFVHVGVHNKGFVQASRDAWQEFRRTVGLEELVDADLTSSICFLSAFGIGAISALTAGIWEFNIHKDYFFQLTLYAFVIGYFVGRVSSAWLQACVMAYFVAYAANPEGVNFDNTISERIARQNVEENKRLADNEMRQPEEEQEITYM
The following text describes a protein:
Function:
Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specific for cAMP.
Sequence:
MESLLTLPLAGEARVRILQITDTHLFAQKHEALLGVNTWESYQAVLEAIRPHQHEFDLIVATGDLAQDQSSAAYQHFAEGIASFRAPCVWLPGNHDFQPAMYSALQDAGISPAKRVFIGEQWQILLLDSQVFGVPHGELSEFQLEWLERKLADAPERHTLLLLHHHPLPAGCSWLDQHSLRNAGELDTVLAKFPHVKYLLCGHIHQELDLDWNGRRLLATPSTCVQFKPHCSNFTLDTIAPGWRTLELHADGTLTTEVHRLADTRFQPDTASEGY
The following text describes a protein:
Function:
Transcription factor involved in the regulation of salt stress response. Functions as a negative transcriptional regulator of salt stress acclimation response by regulating cation homeostasis. Negatively regulates the expression of genes contributing to ion and osmotic homeostasis during salt stress, such as the Na(+) transporter HKT1, the Na(+)/H(+) antiporter SOS1, the aquaporin PIP2-1 and the glutamine synthetase GLN1-3. In addition, targets genes with functions in plant growth and development, such as argonaute 4 (AGO4) and cyclophilin 19 (CYP19).
Miscellaneous:
MISCELLANEOUS: Plants silencing BZIP24 show enhanced tolerance to salt stress. Enhanced salt stress tolerance in silencing plants is characterized by enhanced root and leaves development and reduced sodium accumulation in plants.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Targeted to the nucleus in salt stress conditions.
Sequence:
MFCCCKDCRGNQRVSNFDSLTGVFFGDLEFGPQNQRYIKMNEEEDKDQDRVTRGCSHTHSCNPPGPEDASHSHTCFHAHTHLIISDQQENDHSDSSNKKRLCGNREAVRKYREKKKARTAYLEDEVMRLQSLNEQFLRKLQSQEMVETELIRLRALLVEMQGKIEVELCSFSFQKQCNGSGFVFKEDGCNLATSNMMCEAARVECEEGQTLHDPIQSFVPQPPPFSR
The following text describes a protein:
Function:
Carboxylate clamp type tetratricopeptide repeat protein that may act as a potential Hsp90/Hsp70 co-chaperone. Contributes to polar growth of root hairs.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein.
Sequence:
MGKPTGKKKNNNYTEMPPTESSTTGGGKTGKSFDRSATKSFDDDMTIFINRALELKEEGNKLFQKRDYEGAMFRYDKAVKLLPRDHGDVAYLRTSMASCYMQMGLGEYPNAINECNLALEASPRFSKALLKRARCYEALNKLDFAFRDSRVVLNMEPENVSANEIFERVKKVLVGKGIDVDEMEKNLVNVQPVGAARLRKIVKERLRKKKKKSMTMTNGGNDGERKSVEAVVEDAKVDNGEEVDSGRKGKAIEEKKLEDKVAVMDKEVIASEIKEDATVTRTVKLVHGDDIRWAQLPLDSSVVLVRDVIKDRFPALKGFLIKYRDSEGDLVTITTTDELRLAASTREKLGSFRLYIAEVSPNQEPTYDVIDNDESTDKFAKGSSSVADNGSVGDFVESEKASTSLEHWIFQFAQLFKNHVGFDSDSYLELHNLGMKLYTEAMEDIVTGEDAQELFDIAADKFQEMAALAMFNWGNVHMSKARRQIYFPEDGSRETILEKVEAGFEWAKNEYNKAAEKYEGAVKIKSDFYEALLALGQQQFEQAKLCWYHALSGEVDIESDASQDVLKLYNKAEESMEKGMQIWEEMEERRLNGISNFDKHKELLQKLGLDGIFSEASDEESAEQTANMSSQINLLWGSLLYERSIVEYKLGLPTWDECLEVAVEKFELAGASATDIAVMVKNHCSSDNALEGMGFKIDEIVQAWNEMYDAKRWQIGVPSFRLEPLFRRRSPKLHDILENVFSGPQ
The following text describes a protein:
Function:
Required for establishment of sister chromatid cohesion during S phase but not for its further maintenance during G2 or M phases or for loading the cohesin complex onto DNA. Interacts with the three known alternate replication factor C (RFC) complexes, suggesting that these complexes have essential but redundant activity in cohesion establishment. Acts by acetylating the cohesin complex component SMC3. In vitro, possesses acetyltransferase activity where it can acetylate itself and components of the cohesin complex (MCD1, IRR1 and PDS5), but is unable to acetylate histones.
Subcellular Localization:
Nucleus. Note=Associated with chromatin.
Sequence:
MKARKSQRKAGSKPNLIQSKLQVNNGSKSNKIVKCDKCEMSYSSTSIEDRAIHEKYHTLQLHGRKWSPNWGSIVYTERNHSRTVHLSRSTGTITPLNSSPLKKSSPSITHQEEKIVYVRPDKSNGEVRAMTEIMTLVNNELNAPHDENVIWNSTTEEKGKAFVYIRNDRAVGIIIIENLYGGNGKTSSRGRWMVYDSRRLVQNVYPDFKIGISRIWVCRTARKLGIATKLIDVARENIVYGEVIPRYQVAWSQPTDSGGKLASKYNGIMHKSGKLLLPVYI
The following text describes a protein:
Function:
Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Is able to repair glycated serum albumin, collagen, glyceraldehyde-3-phosphate dehydrogenase, and fructose biphosphate aldolase. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. In vitro, prevents acrylamide formation in asparagine/glyoxal and asparagine/sugar mixtures at 55 degrees Celsius, likely by degrading asparagine/glyoxal Maillard adducts formed at high temperatures. Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity. Is a general stress protein; is required for the protection of bacterial cells against many environmental stresses, including oxidative, thermal, osmotic, UV, and pH stresses. And plays an important role in protection against electrophile/carbonyl stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKKIAVLITDEFEDSEFTSPADEFRKAGHEVITIEKQAGKTVKGKKGEASVTIDKSIDEVTPAEFDALLLPGGHSPDYLRGDNRFVTFTRDFVNSGKPVFAICHGPQLLISADVIRGRKLTAVKPIIIDVKNAGAEFYDQEVVVDKDQLVTSRTPDDLPAFNREALRLLGA
The following text describes a protein:
Function:
Possible structural role in the sperm tail.
Subcellular Localization:
Cytoplasm.
Domain:
The predominant structure is alpha-helical.
Sequence:
MSLCRCSSICLRRPILRSFNFLNKYIDQSQHSGGLSSFQRLSFSNTGKNESTDDSNQIRCDADKTAADKKKQKQKEEEQAKIREYKRECLKVQKRVLAEEIRCSGEKDRILIQGMMKCLTDGMKKACTKIAKAKLIADKELAVQCAALSKKDKVKALLKKCEREKSKEKECNQNSPAEGDKDRTKKGKTKGKSGGGNKKRSTKENRAKKGKKLVKNRFTQKLEHCIKSEWADVCECRQNFTEDERKRLAASYKCMGTKIKSICRKRVIAEMCEAAGYVKSSEPKKKGKKKKNDEKKEKELEREILKEQAEEEAKIRGVVKEVKKKCKEKALKKKCKDLGRKMKEEAEKKKCAALAKKQKEEDEKKACKELAKKKKEADEKKKCEEAANKEKKAAEKKKCEKAAKERKEAAEKKKCEEAAKKEKEAAERKKCEELAKNIKKAAEKKKCKEAAKKEKEAAERKKCEELAKKIKKAAEKKKCEETAKKGKEVAERKKCEELAKKIKKAEIKKKCKKLAKKEKETAEKKKCEKAAKKRKEAAEKKKCEKAAKKRKEAAEKKKCEKSAKKRKEAAEKKKCEKAAKERKEAAEKKKCEEAAKKEKEVAERKKCEELAKKIKKAAEKKKCKEAAKKEKEAAEREKCGELAKKIKKAAEKKKCKKLAKKEKETAEKKKCEKAAKKRKEAAEKKKCAEAAKKEKEAAEKKKCEEAAKKEKEAAERKKCEELAKKIKKAAEKKKCKKLAKKKKAGEKNKLKKGNKKGKKALKEKKKCRELAKKKAAEKKKCKEAAKKEKEAAEKKKCEKTAKKRKEEAEKKKCEKTAKKRKEAAEKKKCEKAAKKRKEEAEKKKCEKTAKKRKETAEKKKCEKAAKKRKQAAEKKKCEKAAKKRKEAAEKKKCAEAAKKEKELAEKKKCEEAAKKEKEVAERKKCEELAKKIKKAAEKKKCKKLAKKEKKAGEKNKLKKKAGKGKKKCKKLGKKSKRAAEKKKCAEAAKKEKEAATKKKCEERAKKQKEAAEKKQCEERAKKLKEAAEQKQCEERAKKLKEAAEKKQCEERAKKLKEAAEQKQCEERAKKLKEAAEKKQCEERAKKEKEAAEKKQCEERAKKLKEAAEKKQCEERAKKEKEAAEKKRCEEAAKREKEAAEKKKCAEAAKKEKEATEKQKCAEAAKKEKEAAEKKKCAEAAKREKEAAQKKKCADLAKKEQEPAEMKKCEEAAKKEKEAAEKQKCAKAAKKEKEAAEKKKCAEAAKKEQEAAEKKKCAEAAKKEKEAEKKRKCEKAEKAAALKRQCAKLVIRAKEAALRKKCAIIAKKAKMAAEKKECEKLAKKAKEAIEWKKCAKLAKKKREAEKKKCAKLAKKEKEAAEKKKRCKDLAKNKKKGHKKKGRNENRKKRTDC
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MTASHSLALSMTKSTSPLILTLTLSLQPPLKHPRKRETFQEIQAYPNAEVISLSPKSLMATNRFFCEICNKGFQREQNLQLHKRGHNLPWKLKQKTNKNQVKKKVYICPEKSCVHHDPARALGDLTGIKKHFSRKHGEKKWKCDKCSKKYAVISDWKAHNKICGSREFRCDCGTLFSRKDSFISHRSFCDVLAEESSKFFSVPSPLAANSTIATVTDTNNPILIQSQLDQSSTGTADLNVNNNHTTLFGQKFTNSNPTQQQPNALALSSPPSPRSTSDSVHNLWKLQEEECAHQWLLNEYMNNNKNIFHKGIFKNQEDEIKKGNIYSGSNPTDGNIASLFSYNQEAVNMASFSATTLLQKVAQTGTPSSSETSTTMFGQMTSSIFNNTMLNSYCLTAKNNEEELTRDFLGVGSSEDQQRLHRHRFPSSVPLTANHDIPKLAATIVGRKQP
The following text describes a protein:
Function:
May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling; Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MARAELSIGLLLLLTCGFSNAQGWRSWFWGPEQTTIPPSEAPSPKEQTEETEWTTQHLAKPEPTTTSSIPLESSTQQKGTVWTISTLKRPNFTATTSIPAVTSPSQLDSKEGDIAGVGAEILNVAEGIRNLVQLWDEKTTETTKTTKAPATTEAPATTETPTTVDLLKSSPTPGTEPGSTLNTTANSTGDAQPLLETGQPKEVTLVTTKPTLLWNKTRVLLKKPAFPLPGSSSFSFSPDDYVSGTMVAFQESTRAGQESTTSSETRATWGASSDKQGVLPGANVSELQEPRANHSSRVDGGITSKVVGALDNWLLHSIANPNQSLSKGNRAHLHLKNHPFFNYSGIVVADATKNHSRDSVSHSNATNVMDFSSGNTSDSLEFLLTYTVQHFSNSSTGLPSFFPGLTPTAGHCLPLPTKLSYCNNLGMKHFRVPNYLHLGSEEEIQAALHEWEGLLKSRCHRYLEWFFCLLLVPGCNASLPITPPPCRGFCEALKDLCWIHLKEGQLPISCNSLPEEDGVYSCVFVNVSAENLSTEVGLIELIGDPPPEQITKVYGPDNSPGYVFGQDANTGQVARYHLPSPFYRDFSLLFHVQPTTEKPGVLFAITDSSQSIIYVGVKLSEVKDGKQQIIFYYTEPGSQNSYAAATFLVPSMVNRWTRFAISVEDEEVVLYVDCEEFERVHFERSPDEMELEDGSGLFVAQAGGADHDKYQGVIAELKVKGDARAAELQCEEDEDDSDMMSGDGGSGIEEKPRLPEKARVTPVVSGLPVPPPVTSPPIAKTPTEQEEKPHLHTDIAEPKEKSPSAAGVGAKGEKGDSGEKGERGPKGDSGLGGVVSTGGAKGEKGEKGDLGVKGNAGFGYPGSKGQKGEPGAEGSPGPTGPPGPPGTIVKHSDGSVIEQVAGQPGPTGPPGSPGKDGLPGKDGEPGDPGEDGKPGDVGPQGFPGTPGEPGQKGEKGDPGVGARGPPGPPGPPGFSSKLDKLTFIDMEGSGFGSDLENLRGPRGPPGPPGPPGVPGLPGQPGRFGTNGTDLPGPPGLPGVTGRDGSPGLPGPPGPPGLPGRDGISGQPGLNGARGEPGEIGLPGAPGPKGDVGLPGEPGQIGLAGLPGPMGPRGQPGPPGPPGPGFVAGFDDMEGSGLPFVSAVPGARGPEGPQGPPGLPGPMGDPGTIGLPGIPGPKGPSGLPGLDGHPGSAGFPGPQGEKGDKGDPGTKGEPGQDGIGLPGPPGLPGPPGQIIHLSGDNTNVPLLPGPEGKQGHAGFPGPVGPKGDIGSPGFPGSPGLKGDKGEPGVIIGPDGTVIATNSKGEKGEGGPRGPVGPLGPPGRPGQKGEIGFPGRPGRPGMNGLKGEKGDPADPSGGLGVRGPPGIPGPPGPPGPPGTVVPVYDNNAFGDVGPPGPPGLPGYHGAPGQKGDKGDVGPPGPPGQFPYDFSTFDSPFWGERAEKGESGEKGEKGEPGGGGLFGPGAAGLPGHPGYPGPPGPKGDSVRGPPGPPGPQGPPGAGFEGRPGPPGPPGSPGPPGPPSFPGPHRQAISIPGPPGPPGPPGPPGSNDASSPSGPQILPTYQSMMSRSHEVPEGQLIFIRDREELYIRVRNGFRKILLEERISLSGPGLDNEVYDRPSSVHHSHGDTASSGSQRTFQQHLPVHSQYSTYSTAKPWRGDEGAINQHRLPEQPAIQQPHHGAHHQQEPLNAFFHQPEPAPSAVHTHHDFQPALHLIALNTPLSGSMRGIRGADFQCFQQAREVGLTGTFRAFLSSRLQDLYSIVRRADRSTVPIVNLRDEVLFNNWENLFSGSEASFRTGVRILSFDGRDVLRNPAWPQKYVWHGSDSKGRRLTENYCETWRTDDTVVTGQASSLASGKLLEQKSSNCKNAYIVLCIENSFMTSSKK
The following text describes a protein:
Function:
Component of the INA complex (INAC) that promotes the biogenesis of mitochondrial F(1)F(0)-ATP synthase. INAC facilitates the assembly of the peripheral stalk and promotes the assembly of the catalytic F(1)-domain with the membrane-embedded F(0)-domain.
Miscellaneous:
MISCELLANEOUS: Present with 589 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MFMARQVLRNGLFLRSLAPIKITARTVASANAGIKRKSRFDKTMIKPLLLVMIFGSILNAVIAEKRNIIDMERKYKLKLDKLKELIRRVHDNNGKVDFDADDELKLVNLRLGIVGKNATGMKEDETDIVVPKEESLEEIWQSIIDEAKKEVIEKTPDAGVKNKEGIVTDLNVLKDLEKSKKEDEKVYLSGDVHMMMNQPGDLNEIAKEHDKIPKFL
The following text describes a protein:
Function:
ATP-dependent specificity component of the mitochondrial Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
Subcellular Localization:
Mitochondrion.
Sequence:
MAAAVLRSKSSRATASLSSLSHLRNCLLTHDLHTGPLPNFHLTCSRPATTKLDEYQSYKPFLVSGESVDKGYGFLKSNSKWRLSNMYGGSIGGGGGFGEPPEVWQPHGDGGKIVPLSGAGNPTTDGFGSGSGDGNWGGSNLGNSFPTPKEICKGLDKFVIGQERAKKVLSVAVYNHYKRIFMDSSQKPAGNSRNDKGNGVDGETVELEKSNILVMGPTGSGKTLLAKTLARLVNVPFVIADATTLTQATIYSLFIIHLGAGYVGEDVESILYKLLTVADYNVAAAQQGIVYIDEVDKITKKAESLNISRDVSGEGVQQALLKMLEGTVVNVPEKGARKHPRGDNIQIDTKDILFICGGAFIDLEKTISERRQDSSIGFGAPVRANMRTAGVTTAAVTSSLLETVESSDLIAYGLIPEFVGRFPILVNLLALTENQLVQVLTEPKNALGKQYKKLFQMNGVKLHYTESALRLIAKKAITKNTGARGLRSLLENILMDAMYEIPDVRTGKDIIDAVVVDEEAVGVQGQGCGAKILYGEGALEHYLSQHDNNNNNKDLEADGEAELPSIAAL
The following text describes a protein:
Function:
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
Sequence:
MRLVKKEFPDVGELVIGTVKKIAEHGAYVYLDEYDLEAFAPTQEIVQSWFHSIRDYVKEGNKTVFKVISVNPKMRVVEVSLKRVRVDEKEKKLLLYRHRVRVLKLLEIAMKKLNRPAEEALKVMWYLEEQFGDPFKVFEEVVKTGPHVLDDLQLDAKLKEIIIELARQQVELPPTKISGIIKIVSVEGDGVEKIKAALIELEKTLREKFPQISTKIYVVGPPRYRIDLTGQQPKQVEAAFSEAANILQALQKKYKVIGNIQRIEQ
The following text describes a protein:
Function:
Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate.
Miscellaneous:
MISCELLANEOUS: Reaction is initiated by nucleophilic attack of cysteine at the double bond, yielding a covalent succinylcysteine-like intermediate.
Sequence:
MAKHFRIGMIVPSSNTTMETEIPAMLQSRMKEIPEETFTFHSSRMRMMHVTKEELKKMDEESDRCAIELSDARCDVLAYACLVAIMCQGPGYHEKSEARLASLTAQNGGAAPVISSAGALIDGIRTLGAKKIALIAPYMKPLTNQVIEYITASGIEVTDSISLEIPDNLEVGRQDPMRLIEIVKNLDVSNADAVVLSACVQMPSLPAIQKVQDQLGLPVLSAATSTVYKILKSLNLKTYVPNAGSLLSGKY
The following text describes a protein:
Function:
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Subunit 2 binds ATP and single-stranded DNA (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MADFFNLKARQQAAAQASSSKTPTSKQESNRLQPWVEKYRPKTLSEVTAQDNTIQILSRTLQSSNLPHMLFYGPPGTGKTSTILALAKQLYGPELMKSRVLELNASDERGISIVRQKVKDFARQQLSVAPTYNVMTEDKDGGEAKMVRYRDKYSCPPFKIIVLDEADSMTQDAQSALRRTMETYSRMTRFCLVCNYVTRIIDPLASRCSKFRFKSLDQGNAVRRVDDIAKLEDVKLDAGVSEELVRVADGDLRKAITFLQSAARLVGATQTAGRKKKVVVDDEDEMDIDPPSAPSKTTISLEQIAEIAGVIPAPTLASFSDALFPKSAAKSIRYNEIAKVVENMIAEGWSASQTVSQLYEQVMFDERVEDIKKVRLAGVFSETDKRLVDGGDEHLAVLDLGVRVAGVLCMG
The following text describes a protein:
Function:
G-protein coupled receptor required for the regulation of plasma cholesterol levels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWSCEDLNYTNSGEEQYLCNEFHLFLFIFSVLYLIICFPVGLCYNVQLVLVNLYNKATMTMPDVYFVNMAIAGLIINAVAPVYLFGPAYTKWSLWSFGNEVYITLLILFNVSSLVIMYSTTLLSLDYYIECALPRTYMSSVYNTKHVCGFIWGGAVLTSFSSLLFYICNHVSTKIIECSKMQNREAADAIMVLIGYVVPIIAVIYALVLILQIRKEATPLDQESGRLDPSVHRLLIATVCTQFILWTPYYVTLLVNTFMDARVKSSNTFYIRIFQFTEGLSNFLAFSSSFVLPLIHRHINKNFSGKLQRLLKRLHCGSQGCTHEHTVVQQVMT