lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
STE6 is required in yeast MATA cells for production of A-factor pheromone. STE6 is involved in the transport of the farnesyl-derivation of the A-factor pheromone.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNFLSFKTTKHYHIFRYVNIRNDYRLLMIMIIGTVATGLVPAITSILTGRVFDLLSVFVANGSHQGLYSQLVQRSMAVMALGAASVPVMWLSLTSWMHIGERQGFRIRSQILEAYLEEKPMEWYDNNEKLLGDFTQINRCVEELRSSSAEASAITFQNLVAICALLGTSFYYSWSLTLIILCSSPIITFFAVVFSRMIHVYSEKENSETSKAAQLLTWSMNAAQLVRLYCTQRLERKKFKEIILNCNTFFIKSCFFVAANAGILRFLTLTMFVQGFWFGSAMIKKGKLNINDVITCFHSCIMLGSTLNNTLHQIVVLQKGGVAMEKIMTLLKDGSKRNPLNKTVAHQFPLDYATSDLTFANVSFSYPSRPSEAVLKNVSLNFSAGQFTFIVGKSGSGKSTLSNLLLRFYDGYNGSISINGHNIQTIDQKLLIENITVVEQRCTLFNDTLRKNILLGSTDSVRNADCSTNENRHLIKDACQMALLDRFILDLPDGLETLIGTGGVTLSGGQQQRVAIARAFIRDTPILFLDEAVSALDIVHRNLLMKAIRHWRKGKTTIILTHELSQIESDDYLYLMKEGEVVESGTQSELLADPTTTFSTWYHLQNDYSDAKTIVDTETEEKSIHTVESFNSQLETPKLGSCLSNLGYDETDQLSFYEAIYQKRSNVRTRRVKVEEENIGYALKQQKNTESSTGPQLLSIIQIIKRMIKSIRYKKILILGLLCSLIAGATNPVFSYTFSFLLEGIVPSTDGKTGSSHYLAKWSLLVLGVAAADGIFNFAKGFLLDCCSEYWVMDLRNEVMEKLTRKNMDWFSGENNKASEISALVLNDLRDLRSLVSEFLSAMTSFVTVSTIGLIWALVSGWKLSLVCISMFPLIIIFSAIYGGILQKCETDYKTSVAQLENCLYQIVTNIKTIKCLQAEFHFQLTYHDLKIKMQQIASKRAIATGFGISMTNMIVMCIQAIIYYYGLKLVMIHEYTSKEMFTTFTLLLFTIMSCTSLVSQIPDISRGQRAASWIYRILDEKHNTLEVENNNARTVGIAGHTYHGKEKKPIVSIQNLTFAYPSAPTAFVYKNMNFDMFCGQTLGIIGESGTGKSTLVLLLTKLYNCEVGKIKIDGTDVNDWNLTSLRKEISVVEQKPLLFNGTIRDNLTYGLQDEILEIEMYDALKYVGIHDFVISSPQGLDTRIDTTLLSGGQAQRLCIARALLRKSKILILDECTSALDSVSSSIINEIVKKGPPALLTMVITHSEQMMRSCNSIAVLKDGKVVERGNFDTLYNNRGELFQIVSNQSS
The following text describes a protein:
Function:
Probable transcription factor. Required for asymmetric cell division in neuroblasts, perhaps acting by regulating spindle positioning and myosin polarization, and thus the position of the cleavage plane. Required to produce daughter cell size asymmetry in neuroblasts undergoing asymmetric cell division, usually giving rise to one precursor cell and one apoptotic cell. Positively modulates expression of the serine/threonine kinase pig-1/MELK during asymmetric division of the Q.a neuroblast. Plays a role in neural fate specification in several dopaminergic lineages, including the hermaphrodite-specific neuron (HSN)/phasmid neuron (PHB), acting in concert with the kinase, ham-1, and the T-box protein tbx-2 and the homeobox protein egl-5.
Subcellular Localization:
Cytoplasm, cell cortex. Nucleus. Cytoplasm. Note=Distributed asymmetrically in the cell cortex in some embryonic cells, including the hermaphrodite-specific neuron (HSN)/phasmid neuron (PHB) neuroblast. Localized to nucleus during interphase and evenly distributed in the cytoplasm of dividing Q.a and Q.p neuroblasts.
Sequence:
MTYLAVVLNGPKAKNGRKVFDSFLEQNRQMFWNRELTSACESITYMGFMRPGTLFVSGPASQLTVLKDAWARRILKPAMGYTITSLGDLGAIQQVEQMHFVPLGDVICDAVAQLNRQGLAATEQAIRQYVARHCPHVAPPGIEMVRQTITSLLSTGFVYKMADHYFVSVPTNSPMRPPAKAATKTTKTTVECQTGASMMCPQQTSTSSDEHVIEPAKKDHKKCQNSNRRSIFARLFSRGMKPQTIMPSASPIHVGGPPTPPPAAMLPTKNKYPTYHHDLNEECQRKARRRNHPRRGETQKLLSSSSECLKYYPVDMPETRPTRRRARMASPLRSSTPNNSDSAYSISPPHTDSNEEAGSISDSEINHTYININKFRRQNFDSTQFEDLTGATATTSEEPEILGRHIRGVLISNL
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLEEWLCRTSIPRPPGIFSSLCAARAAAPPVCGLDGHCSCSQGRLCAASLGARLRVSRPHLYGPRTLHFRDSLRSDGLKTIQGRSGNRRSPSWLRFHGGGGGAKGAGSRKRRGGRWAAAECGRAGAVRGGEAGCRWPGGTNKDGGGPCGGTDLGIGCGHGCSPALGGAARGEQGVALSWGSAPAGLPRRLTGGQVQPVVSTMPQASEHRLGRTREPPVNVQPRVGSKLPFAPRARSKERRNPAPGPNPMLRPLPPRPGPPEERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLRPMGIALGGHRGAGELGAALSRLALRPEPPTLRRSASLRRLGGFPGPPTLLSIRTEPPTSHGSFHVISARPSESFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILASSPAPAQPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFSLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL
The following text describes a protein:
Function:
Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MTVMNLFFRPCQLQMGSGPLELMLKRPTQLTTFMNTRPGGSTQIRFISGNLDPVKRREDRLRKIFSKSRLLTRLNKNPKFSHYFDRLSEAGTVPTLTSFFILHEVTAILPLFLLWWLLYNLDLSDDFKLPNFLNGLMDSCHTAMEKFVGKRYQECLNKNKLILSGTVAYVTVKLLYPVRIFISIWGAPYFGKWLLLPFQKLKHLIKK
The following text describes a protein:
Function:
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, leaving the last ubiquitin chain attached to its substrates. Catalytic subunit of the BRISC complex; does not have activity by itself, but needs to be associated into a heterotetramer with ABRAXAS2 for minimal in vitro activity. Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating spindle assembly factors (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Note=A minor proportion is detected in the nucleus. Translocates into the nucleus in response to DNA damage. Directly binds to microtubules and is detected at the minus end of K-fibers.
Sequence:
MDDSSLQKVELQTDVYMVCLQHALSTENFEVMGLLIGNFACGIAKISAVIILRRLDKKKDRVEISSEQLLKAAAEAERLTVELNRPMRVLGWYHSHPHITVCPSHVDVRTQATYQTMDHSFVGLIFSVFSEGKESKEHEIFLNCFQSDNGEATEIPLEIVHTPDISDRCLRTMTDLSKILVQEEEDMAEACKDHPDVLASIHNNAVRTRALIHITDIITKPLVQTFEKRIALNKLRATHLQRQLQELQKMCNG
The following text describes a protein:
Function:
Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGRQGSGNAVRISPSSRNQPYFSSAHLSFVVPFPVHSKYVVRSGYVLPVDPLFVAKINPFWLRFDPPSAGEHYGLAVFYFLMMLFGVIGNALVVFMFYRYRSLRTPANYLVINLAVADFIIMMEAPMFIYNSIHQGPALGSIGCTVYALMGAVGGTVAIATLTVISIDRYNVVVYPLNPNRSTTKLKCYFLIAFTWAYGLLFASFPALEIGLSRYTAEGYLTACSFDYLDRTYKARVFMFVYFVFAWLIPFAIISYCYARILIAVINANAIQSSKSKNKTEVKLAGVVVGIIGLWFAAWTPYAVVAMMGVFGYEQYLTPLNSMIPAVFAKIAASIDPYFYAMNHPRYRQMLERMFCNRGADQGNSQYQTSHYTRGASRGGDSEGGGGEESGGGGGVGRAPGGGNAGLGRGGTVRGGGGGGRLIAGKGGGGANATGSTGGGGVKALKKQISNGDETSLEVSLEM
The following text describes a protein:
Function:
May be involved in floral abscission.
Miscellaneous:
MISCELLANEOUS: IDL4 is only partially redundant with IDA.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MYPTRPHYWRRRLSINRPQAFLLLILCLFFIHHCDASRFSSSSVFYRNPNYDHSNNTVRRGHFLGFLPRHLPVPASAPSRKHNDIGIQALLSP
The following text describes a protein:
Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Sequence:
MARKGLMEQDLSKLDVTTLHPLSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLGYANAKIYKCEDERCPRPKCYKAYGSGKEDNPMCDVEGFQNCRMNLLRHVSFVDCPGHDILMATMLNGAAIMDGALLLIAANESCPQPQTSEHLAAVEIMRLQHIIILQNKVDLIQENAAINQHEAIQKFIQGTVADGAPVVPISAQLKYNIDVVCEYIVKKIPIPERNFTSPPNMIVIRSFDVNKPGYEVDEIRGGVAGGSILRGVLKVNQFIEVRPGIIVKDEAGNMKCTPIYTRIVSLYAEQNELQFAVPGGLIGVGTTMDPTLTRADRLVGQVLGDVGSLPEVFGELEVNFFLLRRLIGVRTKGSEKQGKVSKLTKGEILMLNIGSMSSGARVLAVKNDLAKLQLTSPVCTSKGEKIALSRRVEKHWRLIGWGMIQAGTTIEVPPCPL
The following text describes a protein:
Function:
Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways. Has spontaneous activity for beta-arrestin recruitment (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Colocalizes with ARRB2 in the endosome.
Domain:
Lacks the conserved DRY and BBXXB motifs. The restoration of these motifs affects its constitutive activity.
Sequence:
MANGSGLSVTELAGSVGFILAVLVEVGAVLGNGTLLVVVLRTPDLQDAFYLAHLCVVDLLAAASIMPLGLLAAPPGLGTVPLDPSSCRAARFLSAALLPACTLGVAALGLARYRLIVHPLRPGARPAPALVLTAVWSAAALLGALSLLGPPPAPPPAPARCSVLAGGLGPFRPLWAMLAFALPALLLLAAYGSIFLVARRAALRPPRGTRPRSDSLDSRLSFLPPLRPRLLGGKAALAPALAVGQFAACWLPYGCACLAPAARAAAAEATVTWVAYSAFAAHPFLYGLLQRPVRLALGRLTRRALPRAPKACTSQAWHLQTLLRRLQELRKDPVLGPSEAPEQARELARQTPSVSEAT
The following text describes a protein:
Function:
Aldehyde reductase that catalyzes the reduction of the aldehyde carbonyl groups on saturated and alpha,beta-unsaturated aldehydes with more than 5 carbons. No activity on alpha,beta-unsaturated ketones. Can use propionaldehyde, butyraldehyde, methylglyoxal, (e)-2-pentenal, (E)-2-hexenal, (Z)-3-hexenal and (E)-2-nonenal as substrates, but not propenal (acrolein), crotonaldehyde, 2-butanone, 3-buten-2-one or 1-penten-3-one. May act as a short alcohol-polyol-sugar dehydrogenase possibly related to carbohydrate metabolism and the acquisition of desiccation tolerance (By similarity). May also be involved in signal transduction (By similarity).
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASEKQKQHAQPGKEHVMESSPQFSSSDYQPSNKLRGKVALITGGDSGIGRAVGYCFASEGATVAFTYVKGQEEKDAQETLQMLKEVKTSDSKEPIAIPTDLGFDENCKRVVDEVVNAFGRIDVLINNAAEQYESSTIEEIDEPRLERVFRTNIFSYFFLTRHALKHMKEGSSIINTTSVNAYKGNASLLDYTATKGAIVAFTRGLALQLAEKGIRVNGVAPGPIWTPLIPASFNEEKIKNFGSEVPMKRAGQPIEVAPSYVFLACNHCSSYFTGQVLHPNGGAVVNA
The following text describes a protein:
Function:
Forms a transiant heterodimeric complex with LMO1, that acts as a guanine nucleotide exchange factor exchange factor (GEF) for the small GTPase RHO5. DCK1, LMO1 and RHO5 relocate to mitochondria upon oxidative stress and trigger cell death. The DCK1/LMO1/RHO5 signaling module mediates mitochondrial turnover under nitrogen starvation conditions via mitophagy. The DCK1/LMO1/RHO5 signaling module plays also a function in cell wall integrity signaling.
Miscellaneous:
MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Mitochondrion. Note=Quickly relocates to mitochondria under oxidative stress.
Sequence:
MSQQDSQRWLPTDRLIYGVLVKSFLPLQRYPELVYENSNYANVYVGAEVYVFEESVDKKWCRAYQCLRPFPEEFISNMNSANDVLPDVKPKVVIFPRKYVHFEAEKAVSTMPFFKAPSAEDFKPLISKECESRSFCDSLYVSSTDDISTGKPRKTPRPPFPFFRYQKRSFKDEMGPILSLISSHVYSMYSIGEFSIYRKMIKLYYDLDTIRFRLSMNLTTEAEKINLIRAATSLRTKIAKFLSSTYRKNKLIANSTPRNPDPYGFEGIFARDIDTGELLSYEIDKLRTLVSSSMLCGLTNNFPTVPVVESDDESSSNGLFGTVRSSILVNLKDLAWDPSISDPKYQDLSICVYLRTKDEVLTESFTMTKSSNMESALDEIPAMLFKNILETIVHKNKVYLVVVLKETIAITTETAPEISSYNISTEESSSHSPFSPFNSSTENKIDHVKKGLAAGVINISPVFKFYNGLSVANKAQRFNLYLYSSDSSDSQNFNSSKDADLGWGGLINKIIKDSSEGVSVNPRAVSLSVTVKEIIGKQEAEKVLSTSLVPIRSIPTYFYDTMFSQAERIYLNLGRVSLYGLPAADTNIENVTVQISCRNKAVKFCKNKLEERSGDWKFVSVRPNESIGESIRIEGVENMNEDETLRVLVYLNGFLMAKSNIHIKKKNEIIEYRKGTVFQIMSSKSVPLIHLELEASYFGRRYNINPAITNFLVLQTKNVEFDQQLKEHYSVTLKQLNNVSFKDLLKHFDTILAHYLLLLESVNEATDKKGPSSSLPNIVFSEFVKFLNLMLTHQENSRYWFNRLYKKVMSKELECPNVAPILIKHMTTIFDRSHSSWTRTGTAICRTILYIIVLAIGSSHSDEMPNFSHFFRSLHKFLMLADEPIMADQILLIESIPSMLETMTNHCKVEDLVRFAIGLFECCQEKEMNQKMYSRPLSVREEEYLNTKFNCLLKLINKKVLQNYLTNTESVDKLRLQFLSKTLEWLLTPYTPGDDKCFHVESLRLVNSVFITIIEDYKFDMLQRNLIRLLPYLCKSFVHLRRYCKKARLMRPRRVFTMLFPREIPCNYIPVDSIVNDEVVVEVLLELAIIICEITKIASSRFPSYQSFSEIINLCDKDTLFQSNFYSRQITNENVYTITKTVFLFFKQDWFPGMKWLGVSALLGRSSLILLSLCKDYIIENNSPSPSKESEKRVDMRLWAEYVKVILLVSNHKSASLTKLAITPRKAVYLISGDLKKISAYILNECWDALATGHYNITYAKKYGLGALSDCQFELFVHNQFLIREIFIFAFHRHIDATRICCKILWGLGLNFWRIFGSLQPAVNACIPELFSAYQIGKLRLNDYELERFVSCLFFMMHVPDSDTFFPACMDFLRDLLGFLHIVNEIYKIPNQEEFDDDRTARHIEMFEYLLEANRPELFHKMIYDLFIHFIQKKDFVQAALSLELLAGTYAWDSNDTLEAISFPPLPEQSSFERKEYLLKESARNFSRGQKPEKALAVYKDLIKAYDEINYDLNGLAFVHDQIAGIYTRLQSIDRLVPTYFKVSFMGFGFPKSLRNKSFVFEGLPFEHITSMHDRLLRSYHGSNIVHSQEEVDMLLMNPPMGKYIHVASVEPCLSISDNYNSSDKKSSINNKVRMYIENRDLRTFSNSRRLPGAKGVTDLWVEEYTYHTMNTFPTLMNRSEIVKVTKSKLSPLENAIRSLQVKIQELYGLENMCNKTLKDHGDVNDLFTELSTNITGTISAPVNGGISQYKAFLEPSTSKQFSTDDLGRLTLAFDELVAVLGRCLTLHAELLPSKDLKPSHDLLVRLFEENFAEEIERYSRTLSEANRSRNNMITARIISHKNPNKKASFSGRDHHTSGSNHSQFVLEHSDSFGPNSLLFGKYLTRTLSHSSTTSSLDKSGIVSGTSSTFLAGSQPNTNTDSQHKHDYSHSG
The following text describes a protein:
Function:
Involved in repair of DNA damaged by oxidation by incising DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (Fapy) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Miscellaneous:
MISCELLANEOUS: Transgenic seeds over-expressing OGG1 exhibit enhanced seed longevity associated with reduced DNA damage, enhanced seed tolerance to abiotic stresses and improved germination performance under abiotic stresses.
Subcellular Localization:
Nucleus.
Sequence:
MKRPRPTSQPSISSTVKPPLSPPVTPILKQKLHRTGTPKWFPLKLTHTELTLPLTFPTGQTFRWKKTGAIQYSGTIGPHLVSLRQRPGDDAVSYCVHCSTSPKSAELALLDFLNAEISLAELWSDFSKKDPRFGELARHLRGARVLRQDPLECLIQFLCSSNNNIARITKMVDFVSSLGLHLGDIDGFEFHQFPSLDRLSRVSEEEFRKAGFGYRAKYITGTVNALQAKPGGGNEWLLSLRKVELQEAVAALCTLPGVGPKVAACIALFSLDQHSAIPVDTHVWQIATNYLLPDLAGAKLTPKLHGRVAEAFVSKYGEYAGWAQTLLFIAELPAQKTLLQSFSQPINKLDESAEVNETSCDTLKP
The following text describes a protein:
Function:
Major capsid protein.
Subcellular Localization:
Virion.
Sequence:
MRSFLNLNSIPNVAAGNSCSIKLPIGQTYEVIDLRYSGVTPSQIKNVRVELDGRLLSTYKTLNDLILENTRHKRKIKAGVVSFHFVRPEMKGVNVTDLVQQRMFALGTVGLTTCEIKFDIDEAAAGPKLSAIAQKSVGTAPSWLTMRRNFFKQLNNGTTEIADLPRPVGYRIAAIHIKAAGVDAVEFQIDGTKWRDLLKKADNDYILEQYGKAVLDNTYTIDFMLEGDVYQSVLLDQMIQDLRLKIDSTMDEQAEIIVEYMGVWSRNGF
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for catalysing the entry and efficient transfer of electrons within complex I. Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
ALHLHTAERLVTKTNEEEFIALGFSFVSAVRTTATAASNLVEIFVDGKPLMVEPGTTVLQACEKVGVQIPRFCYHDRLSIAGNCRMCLVEIEKAPKPVAACAMPVMKGWNILTNSEKTKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGSDRSRFTEGKRAVEDKNIGPLIKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNEMQVGTYVEKMFMSELSGNVIDICPVGALTSKPYAFTARPWETRKTESIDVSDAVGSNIVVSTRGGEVMRVLPRLNEDINEEWISDKTRFAYDGLKRQRLTQPMVKDSSGQLVPTSWEDTLVRVAEALQGAQGKDVAAIAGGLVDAEALVALKDLLNRLNSETLCTEEVFPMAGAGTDLRSTYLLNTRIAGVEEADLLLLVGTNPRFEAPLFNARVRKSWLHNELQVAVVGTSVDLRYTYDHLGDSTQVLQDIASGKHPFSKVLSQAKKPMVVVGSAALQRGDGAAIHAAVSAIAENARASSGVQDSWKVLNVLHRVASQVAALDLGYKPGVEVIRKNPPKVLFLLGADAGCVTRQDLPQDCFVIYQGHHGDVGAPMADVILPGAAYTEKCGTYVNTEGRAQQTRAAVTPPGVAREDWKIIRAISEFTGVTLPYDTLDEVRVRLSEVSPNLVRYDDIEGANYFKQAHELSKAVNQTLLADPLAPPMLTVKDFYMTDPISRASQTMAKCVKAVTEGAQAVEEPSIC
The following text describes a protein:
Function:
May be involved in spermatogenesis.
Sequence:
MGQQFSDQTQLVLNKLPEKVAKHVTLVRESGSLTYEEFLGRVAELNDITAKVASGQEKHLLFEVQPGSDSSAFWKVVVRVVCTKINKSTGIVEASRIMNLYQFIQLYKDITSQASGVLAQSSTSEDPDENSSSVTSCQASLWMGRVKQLTDEEECCICMDGRADLILPCAHSFCQKCIDKWSRSSLAPTGLYLELNLSKRWNVCRPWRETAGQISDHPRTFPSPGLYKEAMLTDAGPLPHESLESPGARAPVLAQSAWGSFSEALCERSRGLAPQGTVARGTADRVS
The following text describes a protein:
Function:
Hydrolase highly specific for thiamine triphosphate (ThTP).
Subcellular Localization:
Cytoplasm.
Sequence:
MGILIVSWCFLYPSTKMTVEVERKFVCDAEIMRKLQDIGAECVGEREFGDQYFDSPDFLLTLKDFWLRCRDGQWELKSPAVSEAPAETLCTRYREITSLPVIQSEVSKIIRESNCSQRKQIGQTEDTPICSTGDTKWLNELGLVCFAEFRTQRCSYVLEREDGAVRVDLDRADFGYCVGEIEVLVPEGGDVNAALQSITSIAEQLGLNSEKKVKGKMDVFLQRNRPDHYNKLLSAHIL
The following text describes a protein:
Function:
RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.
Sequence:
MSSMIGNRRSKWDQPAQAGGGPGLIQQGGNGADNSSPVEAAAAAAAKINAMLVAKGKLKLPAQQNQNSSSKPKSSSVQPQQQNQRKEEVFMAEIEINDVPIGCRNLLTRGHTQDEVHKMSGAAVSTRGRYMSPEDKAKNNYGERPLYLCVQGPIQEAVDKAVNRIKEIIANGMKKEAAKTGVVGTIPGPRPPLLPGTGPPPPLMTQPPIGLPPPQQHLPPGMHYVQDKVFVGLEHAPPNFNVREKVLGVAGSYLDHIQRETGAKVQLRGKGSGTIEATSGREDFSPMYIWVSHTNPAGLDQAKKLCENLLQTIHQEYAKYQQQIAAGIIPPPNIVQGVPQGNMGINTGMPPPSHVGQVGLSQGGPTTAPPPSSMSLPVGLQQPGILQQPAPGQPGLGMPQTTHLTFTGPPLGMQPPHPGQLLPGGAPPGMPGNLPPTTGLVSPVFSQGSLVNPPPSQAVMTAQQIISSLASSQAPPGGMVQTSILSPQLQSLLPPQQQQLPGMQHLDMPGQMSGAPQQHQPQHPFLPGQPPPQQLQMQHSMQPPGQLLRPPMPVTSNQLLQQQPHEMSLGGPPPGPPSLHYSQADQRRGEPPQQQAQKRRFTEEPEKDDLQAILGYQVVSPVYFSKRPEAADVMQPHIHGPPHLTNLGSGPASSQPQPPSSQPQHLPGNLLPPPGGHPGGPPPHLLLPPPPREDERDRQLMPPPPRPPGMPSDRDRQLMPPPPPPSVAMPG
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MASNPDSKLHIPDEMFNFFNSLNTAVDTGDISSFHNLYENIFPSHLSKYYAAEQGEFRPLPVLQRMEVAECFGNDTAGKLYSFLCFKHLFTDRDVTAEDAKVSWRTFCDLFVSLPGSCDIPNWFLWDIFDEFLFQMTVVYQKRFAEGAEWSVTEAVQMMEKVISESGIEEVMESDKADDITKSGENHVRWMSGFFGIITVAKINVLLGDYNSALSVLKPLDIYGRGKKILAEVAPANVSLMYYVGFSYLMLRRYADASRVFRQSLSAKVSSRKFSERVRLDCAFMHVVSCILCGTQPDNLSWLMDSRKLQVLEDDKELLATGDEERFRDVFDRCSPKFLAVPPVPPTVCKGMEGKELQARLFLRAVKQQQDTIKLRVYLGVYQTTTTELVKTVLDVNDGLVPLFAMKLTSRQLVHDGVSADLHSGTYVVRAALDCTVEGDNICVVQKSSYRTIESKYFKRMTQRRPRHRHFDNPRQGRRPAPDAHNTN
The following text describes a protein:
Function:
Catalyzes the transfer of the acetyl group from acetyl coenzyme A to the free amino group of arylamines and hydrazines. Is able to utilize not only acetyl-CoA, but also n-propionyl-CoA and acetoacetyl-CoA as acyl donors, although at a lower rate. As acetyl-CoA and propionyl-CoA are products of cholesterol catabolism and the nat gene is likely present in the same operon than genes involved in cholesterol degradation, this enzyme could have a role in the utilization and regulation of these CoA species; It has been reported that overexpression of this enzyme may be responsible for increased resistance to the front-line antitubercular drug isoniazid (INH), by acetylating and hence inactivating the prodrug. However, isoniazid is an extremely poor substrate for the enzyme; therefore, the expression of TBNAT is unlikely to be a significant cause of isoniazid resistance in M.tuberculosis.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target; MISCELLANEOUS: Reactions proceed via a bi-bi ping-pong kinetic mechanism; MISCELLANEOUS: Resistance to the antitubercular drug isoniazid (INH) has been associated to mutations in this gene in some INH-resistant clinical isolates of M.tuberculosis.
Sequence:
MALDLTAYFDRINYRGATDPTLDVLQDLVTVHSRTIPFENLDPLLGVPVDDLSPQALADKLVLRRRGGYCFEHNGLMGYVLAELGYRVRRFAARVVWKLAPDAPLPPQTHTLLGVTFPGSGGCYLVDVGFGGQTPTSPLRLETGAVQPTTHEPYRLEDRVDGFVLQAMVRDTWQTLYEFTTQTRPQIDLKVASWYASTHPASKFVTGLTAAVITDDARWNLSGRDLAVHRAGGTEKIRLADAAAVVDTLSERFGINVADIGERGALETRIDELLARQPGADAP
The following text describes a protein:
Function:
May bind GTP and have GTPase activity.
Sequence:
MPLLLHPRFPSSHAAACAHRAAAAHRDARPALRLPELHATRRRRNNVACRATRAREAPPQQQNTAAALSKEAHKYFDHAVVTVRAGDGGHGAVLAMPASPSTDAPKSPRRRSDKGKRSGVKKVSYKRNYDGSVALPMGGHGGDVVVYADEAEETLLRFHEKARYCAKRGGNVGATGTLSSRMHNGFAGETLRIPVPVGTVVKRKKGAVLADLAHPGDEVIVARGGQGGISLIDVPEYRRRKAMVLSPNIMRDVSDRVLIHGQPGEEVSLELILRVVADVGLVGLPNAGKSTLLSAITLARPDIADYPFTTLMPNLGRLGGDPALGALQFSSEATLADLPGLIEGAHLGKGLGRNFLRHLRRTRVIVHVVDAAADDPVDDYKIVREELRMYNPQYLERPYVVVLNKIDLPKAQDRLSSLAFEISSIGCEECDGNNTSEDSLNGNTGEHNTSSETKVEGGEKELRDYPRPQAVVGASVLKHIGIDEMLKEIRAALRKCFDHRLPEP
The following text describes a protein:
Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular Localization:
Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.
Sequence:
MTVHNLYLFDRNGVCLHYSEWHRKKQAGIPKEEEYKLMYGMLFSIRSFVSKMSPLDMKDGFLSFQTSRYKLHYYETPTGIKVVMNTDLGVGPIRDVLHHIYSALYVEFVVKNPLCPLGQTVQSELFRSRLDSYVRSLPFFSARAG
The following text describes a protein:
Function:
Binds A/T-rich DNA with a highly dynamic distribution into the nucleus.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Note=Follows a highly dynamic speckled distribution pattern throughout the chromatin of interphase nuclei.
Sequence:
MAFDLHHGSASDTHSSELPSFSLPPYPQMIMEAIESLNDKNGCNKTTIAKHIESTQQTLPPSHMTLLSYHLNQMKKTGQLIMVKNNYMKPDPDAPPKRGRGRPPKQKTQAESDAAAAAVVAATVVSTDPPRSRGRPPKPKDPSEPPQEKVITGSGRPRGRPPKRPRTDSETVAAPEPAAQATGERRGRGRPPKVKPTVVAPVGC
The following text describes a protein:
Function:
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze the modified nucleotides 5-methyl-UTP (m(5)UTP) and pseudo-UTP. Has weak activity with CTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Miscellaneous:
MISCELLANEOUS: Present with 1940 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGNSQLPPDVIGFICSKYDIILASTSPRRYEILHDIMGITDLKTMVSTFEENLDKMNYSTDPIGYVCDTSWHKAQNIIEILTDYEDENPNEIDKPKLIICADTIIIDKSGRIYEKPKTKEVQKKFLMKFCYEDDEPVNVVTAVTLIKWYGRENFELVPFRDETKVYFDNKIPLRILEEYVESGDGLEVGGGFKIQGQGAILIEKIEGDYYNVVGLPLNKTFKGLYAEANSI
The following text describes a protein:
Function:
Plays an important role in generating and maintaining a transparent matrix within the corneal stroma.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MAVGGLLCLGRVREEGMRRKELTKHQKVFLNILQKRSWHDVSAGMGVGCAWRFASANIWTMKLAFSLLLPLVLVLISEVSGQRRKPPRKPTRPPPEPIEPVEPVEPTELPPPLPPGPPSIFPDCPRECYCPPDFPSALYCDSRNLRKVPIIPSRIHYLYLQNNFIDDLPEESFRNATALKWVNLDNNRIRKVDRRVLEKLENLIFLYMEKNQLKEVPAFLPPNLEQLRLSRNQISKIPAGVFNKLENLVLLDLHHNKLSDGVFNKNTFKGLKNLMQLNLAHNILRKMPPGVPSAIHQLFLDRNNIEDIPSDYFKEFPNLAFIRLNYNQISDKGLPKNSFNLTNLLVLHLAHNKLTNVPFISAKLEHLYLNNNSIEKINGTQICPTSLMSIQDFSPSDLDSVPRLRYLRLDGNLLKPPIPLDLMMCFRLLQSVVF
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MADENAEAELDWGGRHSLLVDEDTFFAMEGLQATLQQHEAELRQQDVSEESSTGYCNNFCEALMHYAGSRNSLEHGLPLLEVYCLSINCFAAARPHLTGDSPSVALVLKRLALSCLELLLSVPQNNIPLEAWLQFHGSVQAAHEAMLQYGSTDLHALRNITGEGGAWNNSVMVSLLTGQPTDPDEVNAYLALEGDDFMEMRIKHLEKVGELEKALILIKACANCSLLSNQSTFRQTFVTQLCQLLPSEEAILEISRIDAKDVLDIICNLDAEGDERTAFILCTTYFTQQLQQDSTYCSWELTLLWSKLQRRIDVSLESFIERCLQFAAIARTIYHLLFLIRVIQTEAMQLGLAVSVELCVKALRLPRQDDIEAKTMVCKAVVCLLPDDLEVIRACQLTEFLLSPSQEAFDILEELYLRPDEKYDEENAIIPNFLRCELLLSLKAHWPIDPEFWDWKTLKRYCIQLLGLEPVDEIEDEAAPGELCNLGVVLNEEAGKEEEDECELDALSSAGEQQTVEESEKGQKDSEDVSKLADKHQRDKFLCQICHKEVAETRFCHHARKHMEDGMWTCPVCLQKFKTKKEFEPHSKKHIQISAKDHFKKKKVKKKVDQTKDFFKEDSSDELEPGQIPLDPSLAMYYQSTHDPVVLEHILEKAASVPEKQVESDYVTFDYINTYFKLQDRDVYQCPATDCSKNFKLFKYLGVHIKNEHDSEDPNLKHYLKMKDCREKCTFCRKTFMTAYHHRLHRWIHYGDDPYMCVVTGCGARFDTTNELLAHKHGHGFRLSYCCELKGCSFSYCDLGQLYHHEAQHFRDAAYTCTSPGCKNFYYSRKEFLQHLATHDITFTEKDFEAQRKAKRKLLLAVVESDSAFGSKVETENCVQKSGSSSSSQTLAKGRSSVSQTCVAVCFDGKKFTCGLKKCGKTYTTARELQKHLRIAHSDTFNEKDQLCKKKVQVKHSTTRNEDLPKSDPDNTVKTSSTEKSSPKKALSPASESVDCETTKSNLDLDAALTNIMLGLGQLNLNSSNTRHSMCNSQSTCTPTLNTRSPAKAAHSKNESRSHVTGSESKKLPNKSESPKTHDNNKDVSDKKQKKESVSEEEQPQSKSLTKPYNCEAKSCHYQSTTSCALMQHYIKVHGYSEKMVKEMEVFQSETLEPFKTPDSSENSVLEDDQSQSEFLVQATVKPYACEAKSCNYQSVTSHALLKHYIKIHGYSEKKVKNMEVFQSQIFKPFKCHLCSKSYRNKKELRRHYIQMHHIKEDIVEQMKCSFKKNVVEKAPVLSSPKKNTEVKPQSSKKADVKTQKQDNALWQQKCPKHDYRLWVRKVVTKNVHVKAEKKKKASSETRSDVKNTTVDVRGSRRLISKGNLSYILTKYNKPFHCVHKNCNAAFNNQNALVGHLQMVHHYNRSQLCFPCEHKGCEKQYSTLSSLTKHYRRDHNFTKKEKERKILPKLPCTSKSIPKRQMASTEEPIPRFKCTYANCNESYHLNSSLLRHTSQFHQNQTPQNSANTSGNNEFKTSYKKHVFYRHCDPSDSLVVRLQSTPKKEESKNGCQTKLIISPPSQSSKDSQNMPLKQSLRCCRNDQKINSSENFEGVEETPEEELDEVLKPQRINLKNRFDLIVYRTHEEALQMCQDRCLPVAFPCMIQNCDSVVVSMHSLNRHYINVHRFKRKQLTENKDKLCFTAEQLEEIIQKKSAVSAIPDLTRIPNGVLKMEYQSEPATPGGPSQPMSLHSIKTDSKEKEGIEFSEEPLPDRSLLIEAEDLLYGSPKSSGNPEKPVSEESLNHKDEPESELTAPPLIRPPPLDLSPPATLRITVDESSFEASGKDSKSINIPSSVSISVPTPTRQPLRRKNELSEPPLPPVPLSPVPMDPVEHSLSPRAFDIAAYKPMGFESSFLKFIKDKDEEIKLEKPWTAVVSNPCLKPDPNRRRDCFRRNCSVKENTESGAPISRSRRFRSSPLRHLISKGECTSIQNLRMILERALGGCGDQAIKQLQFLKPVVVLERPKSFASIFDLLPSETKV