lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MAFDQKELEEQLIQAGNKLADPPSSVDELLSLLNRLESYLAKVEQAPRTSMRTALAPCMKELVGNKLLRHPDPDVKAALAACISEITRISAPDTPYDDDQMKEIFQLIVSSFENLHDKLSRSYENRRIVLETVAKVRSCVVMLDLDCDALILEMFQHFLKTIRDHHPKDVFSSMETIMTLVLEESEDISFDLLSPLLESIKKNNEEVFPIARKLGERVLESCGSKLKPCLVQAVRTLGISLDDYSEVLGSIFQEEAKAIKEAAQSPKDNRNGNRNSKSVTNDGVARVGEDEEFNDLDGRKVEQKLEEATKKSRRKPSHSTKSAKPSEKMIDSGSHRKKVLSSSHEDQEVAYAVTSRRAYNVESQVMASPSPSDSLPDENHSEKLCKAETKDSPSNVEVAEAVSKKASEGASISKAKPVKQPVRKVLGQNSGVKKTAGTDSGKKQSGSASGADAKKHSVKKLDDNEGGGGSSSRQLVDKKKRGQEEMVSSPRSDIKSSEDEKLEETTMTNGKRKHASGRKNESDIMEHDQNLVGVRLEVWWPKDRQFYKGVIESFDSRKKKHKVVYDDGEVEVLNLAREKWNVIEADSDADEEEGSDRGSLDASIEMPARKKTKPSSDEPTKQGMPGLSSSGGASGSSKSKGVLKFGQKSTGGYKSNESRTVSDSEDEVSRKFKDSTPKSGSSKSATQTMTGKSKNIGGSKTSKRKDDDTIMPKPSVKSKQETPKSGITKQKTPKTDASEGKPPKGVEKSTVDSGGKGKSNSLKKKDLEDDDSESDVSASEEVEDTKGKTSGDAMNGKKRQRS
The following text describes a protein:
Function:
Transcriptional regulator involved in zinc homeostasis. Represses the expression of the smtB-zur operon in the absence of zinc. Could act as the metal sensor that controls the expression of zur in response to zinc availability.
Sequence:
MVTSPSTPTAAHEDVGADEVGGHQHPADRFAECPTFPAPPPREILDAAGELLRALAAPVRIAIVLQLRESQRCVHELVDALHVPQPLVSQHLKILKAAGVVTGERSGREVLYRLADHHLAHIVLDAVAHAGEDAI
The following text describes a protein:
Function:
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MNQQPLPPQSERRALAIGRAVYEAFQDYHAQFSQITARARQRFETRDWSGAREDAVARIALYDHYISECMLRLRAVLLGQAHDRALWMRARTHYAELLTGLIDQELYKTFYNTLTRRYFRTQGVDAQIEFIALDIEPTDAITVPVARHTYAVSPGRLTEMLVRVLGDYPFEVPYAHRTRCAAAIAVRLLDDLAHWGEHPVRSVELLETVFYRERRAYLVGRLFGEHRFSPCVIALVNDDAGLRAEAVLTRRSDVAQLFSNSRSYFQADLTTVGDAVVFLRSLLTHKPIDELYTMLGRAKQGKTERYRTFFRHFQAHPAEQLVHADGTPGMVMVVFTLPSYPLVFKLIRDRFAYPKTMSRAQVEGKYELVFQLDRIGRLLDAQPYRFLRFPKARFSPALLQDLQSSCAMSLSEDGDDVLIALCYVQRRLRPLNLYLREQLPAAAHAAALDYGQAIKDMARNNIFPGDMLLKNFGITRHQRAVFYDYDELCLITECTFRDWPTPTSYEEQMAAEPWFHVGPRDVFPERFALFMGLPSSQLEAVKHMHPELFDPQWWRDLQARLREDDYPDTPPYADAQKLA
The following text describes a protein:
Function:
Transcription activator of the mannan synthase CSLA9. Recognizes and binds to DNA-specific sequence of CSLA9 promoter.
Subcellular Localization:
Nucleus.
Domain:
The NAC domain includes a DNA binding domain and a dimerization domain.
Sequence:
MEKRSSIKNRGVLRLPPGFRFHPTDEELVVQYLRRKVTGLPLPASVIPETDVCKSDPWDLPGDCESEMYFFSTREAKYPNGNRSNRSTGSGYWKATGLDKQIGKKKLVVGMKKTLVFYKGKPPNGTRTNWVLHEYRLVDSQQDSLYGQNMNWVLCRVFLKKRSNSNSKRKEDEKEEVENEKETETEREREEENKKSTCPIFYDFMRKDTKKKRRRRRCCDLNLTPATCCCCSSSTSSSSVCSSALTHTSSNDNRQEISYRENKFCLFL
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted, extracellular space.
Sequence:
MRFFPWGFWLLCVASAPARGDSGSKARSCAEVRQLYGAKGFSLNGVPQAEISGEHLRICPQGYTCCTSEMEENFANKSRSEFEAMMKEAGRSVQTILTAQYRSFDTFLSFLWDTPVLKPHITLDYFQDLLNKSEKALYDTFPSLYGELYTQNMKVFKDLYSELRRYYRGSNINLEEALNEFWTRLLERLFKLMNAQYHITDEYLDCMVKHAEQHKPFGEVPRDLKLKATRAFIVARSYAQGFLVGSDVVKKVSQVSLSHECTRAVMKLMYCPHCRGMASVKPCSNYCLNVVKGCLANQADLNTEWKYLMDALVAVADRIDGPYNVDTVIGTIHMRISEAISNLQENKDSITAKVFQGCGNPKISTKGSSSEDKKRRGKVTLEPKSSAVALEMLVLDAKGNLTALKSYWVTLPGVLCSKKVMASSAADDKCWNGMTKGSYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLGNANIGNDVDFQDASDDMSGSGSGDSCPDDVCGKRLSKNPSTRQPETHAIPKQSGHGVTGASSRSLPSAFLLFLSGASIAAQHLWR
The following text describes a protein:
Function:
Regulator of the cAMP signaling pathway specific to sexual development. Controls the levels of external cAMP by regulating the expression of phosphodiesterase pdsA and its inhibitor pdiA.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSSTKSGSSKYSSGSSISLIMGFSRSLEKGSFGVLYAMIKGNTFPRILTILSMLIEFCQLSSFGFKHQYPWGGDAGYYLKRIMSPVSHPSDVFGYLGFTILFWIAVGLLILGFLNIWYVAYQFYRGKIANIWIIRTLRWFVSFSVAVLFIPIISLLLIGLDCEGSSEGTILRKFDNETIQCFRGANLPIAVISIILIVVFSIVAFTSSATYYEYDTNVKSRFSKPHARFDVTVLFAKFVFAFFNSLVDFVPWLTSITFFVFMVILTFGSIIVLPYNNQRLNQVRSGFYTVVLWVSFMTLVTMGINDETSPATCYITIVGVFFAFPIGFFSNMFYFKWLSSKVSDIQILNQSPSMDLKDANKKGKRNSVEKESSPTSKVTWGKQPITLGSKRQIIFPFFKKKFVMSFFVEIMARSILNNNNEGVSSSSNESIERANNLYQCGLQYFPNSDLLWMAYCNFLFTVRKDRHIGYAALEKLRRMKPSFDVRFFIYQRDKEREQIMDSDLRGPEHTGKIQDFVSYMEFKKLYYGAKRHHVKCLNYIKRFWGHLLHETVDLHRLSDLSGRIATTENKANESYERLLALNPNSVRVLRDYSQFLEEVVKDKESSYKLQKKAEAIEDIMSKSQTTDFKISDIKAIDSDEDDIEKTLQEPTAIQLAKIDADIEKSGSKSGSSKSKDDSSESSSSSKGRRGKYKEFQQSNAINKLSWLMIGTTCCCIIFLIVVLVVFRGLEVKHTNAYQGIISITDCANEAVQMGMHLNAMQAYALVAGVGNNTVEASLIEIARRRALVKRGIIIMKNIHDAIYWGEGNPVSYVGDNLSQLKARDGYDIFDIGSVIFTFDQFNRSSTLLDNKQMIELYSQPSVNMSVLVAPPGSNTTSLYTQTYNAWKAGNAFIESAMLASDVTFDELRYSVNQNPNFKFVTINAPVIMPDIYNKVQTAYIDSLVSDITGTLDAILYTWCGIFAVLFLICAVLFRPIVRKISREKIRTLVLFSLAPKDVVVKLSTKKIKMVSLDSGSERDNLFDTTDDDGRDDHLGEDDNNIQTPVGDNNNNNNNNNNNNNNNGSISSNVTKSDGEIGSDGVRSSSGSNVLNTSSPYRDRRPLMDSTSVLASTATLNNRNVRLQAKDEEITNGGGERKGSDATRTALSEDKKYGWDGKSKRNLNKKSLKSILGRLHWSYILATFLLFGFITMGIWVTFTVVFNNSQSGYTLGKSCSRSLNSRVINYYVAELYTYSQYVSTQNMVDAITELQSSHQSLPYLEEVRPLMEGSYGCWALNKSTCLPPSSMYYEEVNSGLDRVVDSLAKKAINLAYTDQAALLDSPDLQWFLALIDYIFIGLDTATFTYFDYFLEKQEWANTVLTAILSVSCVILLVVHVVLFRPFMNHLRIQHIHTLALLRLAPDDIRYMEVSDKVIDED
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MTGMTRVVIIQDVNITQKYQELLRKLESMGGEKVGRHVRMFMLRMSQNDDLVYAVLANEKAHGIAPSDNGVEGLMEDVSLLECGLDGANILQQVEIYAFKSDGQFEVHNCGLFSLGTQYVVGDFVVSVCTFMSRNNLPRGLIIEVQYSPCYTVSHVDMLIDEFLGNFASHDHLRKPVENMPALFEKVGLPNSEYSLKHTALQYVAAFNILRKFEK
The following text describes a protein:
Function:
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
Sequence:
MSDTPVIGVLALQGDVREHLVALAVADAVARPVRRPEELAEVDGLVLPGGESTTISKLAVLFGVMDPLRARVRDGMPVYGTCAGMIMLADKILDPRSGQETVGGIDMIVRRNAFGRQNESFEAAVDVEGVEGEPVEGVFIRAPWVESVGAAAEVLAEHDGHIVAVRQGNALATSFHPELTGDHRVHRLFADMVRANRAAQSL
The following text describes a protein:
Function:
Involved in neuronal differentiation.
Subcellular Localization:
Membrane; Single-pass type IV membrane protein.
Sequence:
MESRGKSASSPKPDTKVPQVTTEAKVPPAADGKAPLTKPSKKEAPAEKQQPPAAPTTAPAKKTSAKADPALLNNHSNLKPAPTVPSSPDATPEPKGPGDGAEEDEAASGGPGGRGPWSCENFNPLLVAGGVAVAAIALILGVAFLVRKK
The following text describes a protein:
Function:
Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
Sequence:
MLSSVWNFVKRHKKKFVFTGVLVGGIYYLGKYARRKIIEQQKQEALEFIDNMRKQQHYENSQRTCERTIISMLPNLCEALCKQLDTEHLLVGLKSKPDMKIATWEKIKLLSFVRMIVSVYSCCLLVLIFKVQLNINSNVQKRYMQCIQLLFKTVLKRIIADVTAAVSEVIGGLSLKTPMTPSTLHELLTLVRRKVEVKVQNGYHDTDLTVVCKSFSTLTTICLDGLFSQLLSSIAGHFEPMNTTTSTNTNTLVMSKPLAKVIPIVNGLVYLVTGNQPNKFVDVS
The following text describes a protein:
Function:
Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
Sequence:
MPAIKAAAWPMPLDNVFTQTSDDQLETEEAINALFSRLRPSKFDFAKAGSSNSAIINPWLSPAEQDQQRAEASSHAKALSKPTLLLERQAHISFLTKLLEPLPGAYTAFDTNRSWLLYWILHSYDLLSVSLDPKGRARAIATLLSFQNKGSGGFGGGPDQIAHLMATYAAVSALAIIGGPGPAPTAEHVADGKSVEVGHGGWDAIDRTTMYNWISSLKQPDGSFLVHVNGEVDVRAGYCVICITTLLGISTPKLFDGMAPFIASCQTYEGGIAAASQPTYQASADDDILRVSQDVARPPLGEAHGGYTYCAAASSLSLSLLDSSLGGSTTAASSSADFKVVSSSHEPTAQLDRDALIRWATAQQGIPFEGCGFRGRTNKLVDGCYGWFSGGGLFTILSAMIEADLIEQARPSSSAATSSAVEVHDWNGMLTVPATPVILAPSSSSSNSSGSWRTEPSLDAGVANDCGYDSNDATAVDIEDLSPLTLFDRVGLQEYILVAAQRTASDGGGLRDKPGKRPDAYHTCYNLSGLSLSQHSVRLSIETSKFLSQHYKREQEQQDGGWNKKVYATMLAWTLSARDEIVVEATEGTHGSQSNKVNATHPIFNITFPRAKAFMDWSYDQL
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins (By similarity).
Sequence:
MNDDDFGFSGIIKIANVSDFIAPSQACILPLQSKESDVEVQIRVRSRAKKVDDSAVKKVEVTLKDCLACSGCITSAETILIKEQSKPKFLEGLKKAQLSVMTVSPQSIASIAYKRGCHLSEAARLIARIFMNMGMKYVVDSSFGRLLTLSLSYDEFKESQLQRPIFTGVCPGFVCYAEKTHGTLLIPHISCVRSPQAMMGALVKDYLARKFNVRPEEIFHASVMPCFDKKLEAARSHSENHFNCREVDCVLSTGEVDAILDECSSTESFPVDGKVGWLNALENGKIISSEGGSSGGYAEYIVKRFVEESKTPLKLKRTIKDKNWEIIEAVDGETIVLSVAKCYGFRNIQNQVQKLKRSKCNYDYVEIMACPSGCINGGGQIRSASIEERKQLLDTIELPCSEDNSEMEEQLERVKEEWSILNPDWMNLLYTKYHAVVKSDADRISTNW
The following text describes a protein:
Function:
Plays an olfactory role that is not restricted to pheromone sensitivity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein.
Sequence:
MYGRSNRLCAKLSSAFLRKWWFVIAFALSLLVLGALVTFGFTAFIRTIIDHQVALRVGGQSFGWWSRPPVEPIIRIFVYNVTNADEFLNNGTKPILDELGPYVYVQTWEKVNIKENPNGTISYNQKRVYIFNEDLSGGLEDDVVIVPNIPMLSATSQSKHAARFLRLAMASIMDILKIKPFVEVSVGQLLWGYEDPLLKLAKDVVPKEQKLPYEEFGLMYGKNSTSKDTVTVWTGVDDITQYGIIDKYNGRSHQTHWLSEQCNRLNGTDGSIFPPRITKNSTLHVYEKDLCRLLPLSFEKEVTVRGGVKGYRFTPSPDVFASVDKNPNNMCYCPAGPPCAPHGLFNVSLCQYDSPILLSFPHFYMADQTLRTAVEGISPPEKDKHQLFIDVQPDMGTALRARARIQINLAVSQVVDIKQVANFPDIVFPILWFEEGIDSLPDEILDLMKVATNIPPRAKFILTIALFGLGGFLFVVAVICLVRKSHRQSTLHLEGSNYLATASVDQAKKKAKMDNGMSSKSN
The following text describes a protein:
Function:
Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
YLQYHSSHSHNKNTSNNQAASRRNVPEPPSNFTWVDPGWLAACASPTCPSHHKFLFECGIRHVISLMKQRPTNAMESVQLPKLNRLKIRIDDYCAPTLNQIRQFIRIVEDANDRKEAVAVHCANGKGISGTMLACYLVKMKRISAVDALKEIRRMRPGSVESAEQEKAVEQFYQSLLSLCQNC
The following text describes a protein:
Function:
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
Sequence:
MIDFQNNRIQFHQSSSPWIRSFSLESIKCLIVCRGPVRKEAMEIFDSIGIREYGILLSEKDSVVYPMALAPELRGFRFPNNIHRVPDYMGAGKEEKMERIEQIISIAKDNKYTHIFAGYGFMAEDSEFISAIEKSGVVFMGPASYVADQAGSKDAAKKIARKLEVSVTPGVDNISSLALLAKAPDAKSLEKIAKEKGIDFIFDPSLSLEVNAENLLELGYSKIIEFVSIADLQVEAEKECKKIWEKYSKNRIRFKYIGGGGGKGQRVVSKPEEVKGAVQEILSESKVTAPGTNKNFLIELNIENTRHNEIQLIGNGEWCLALGGRDCSVQMHEQKLLELSLTQELLEKEIAACAATHPKKAEVLKGDLKVLREMEEQSERFGAAVKLNSVSTFESIVEGTNHFFMEVNTRIQVEHRVTEMVYSLKFKNPENQNEFFIVDSLIEAMALLSLHGKRLQKPERIFRFPSGAEVRINATNKAIQPHAGGVIMNWSKPLADEIRDDQGISIRNPDMGLFVHYKVAGAYDSNIALLISHGENRKDNLIRLGNILRKTELRGYDLQTNLLVHYGLIHWILGKDAMFKPSTSFMISYLAGVGALEKIIKDVDLEIAWKKIISEASADLKKVLSRKLTLITRPIGELIKDAHLSAGFIGFHLNRSWKISDSKIEWLRNPIFILADLYHYLNMEADPSLPPSEQIWDHDDEVLQKALSFYQELAKRTGSNPDSIELVASLNAGKSLNGIEAGLLSSVLASHNGYQSGLELLKLLPYAGLNSGFYKLEVDEKLEAVIPEEFRKTETRDSLIKFLAPPPKASSDEIVAPMGGMFYSKEAPDLPPMIKVGDHFKAGQPLFIVEVMKMFNKISAPFSGTVKEILLNDSDGKIISKGQTIFKIVPDEVIHIETEAEITERKKKITLSLI
The following text describes a protein:
Function:
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MKVLTELQKQIFTIVKKENGKPIPPGIVVRMMENSPNFPGKHLIYRAIDDLLDWAILRKAGGVTNQLLVNYEPAEPLLDKKLQGILTLGNKNSGFIRSLDDDKTVYYVHYSNLTGALDGDLVEFCKLDKPQFGDKFDAAVITILKRARILYAGNFLVDQNEFALEYKIVADNPRFYLTMIVNPDSIPNNLASNTKIAFQIDEYDPDNNLCKVSVQQVLGNNDDPLINIKAIMLDNSIVFETNDVVEQHANKLSFDTEEQHKAYRQDLTDLAFVTVDPTTSKDLDDAIYVKTIPTGFVLYVAIADVAHYVNRNSEIDIEAKHKTSSIYLPGHYVVPMLPEQLSNQLCSLNPAQKRYVVVCEISFDNQGRIKTNKLYPATIISKNRFSYDQVNKWLNNKSELNCDETVINSLKAAFTLSDLIQAQRQKRGTIDLSHKETEIVVDEHYFPIKINFLVHDKAETMIENLMVVANETVAWVLTNNKIALPYRVHPRPSKKKLQSLIETVGELNITKPQFNLDTVTSSQIASWLNENKDNPSYEIFVILLLRTLGKAFYSVNPLMHFSIGSNHYTHFTSPIRRYIDLTIHRLLWMHLFTPDQFTDNERDQLKQELEKIADTVNDTEIKIINCERNANDYLTTLLLSKQIGKTFSGFISAITSFGIFMRMDENNFDGLIKITTIPDDFFIFEKEKMVLKGRKTNKVYKIGDRLEAKLSEIDFIQKRAILTLI
The following text describes a protein:
Function:
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.
Subcellular Localization:
Chromosome, centromere, kinetochore.
Sequence:
MAVSDKQNLFLKAFLRCVNSKTSSTYQSYALDYVDKSASPLPIEFWYLIKENEFVVVSKTLNKQAKNASDYVDLMIAGSVDNNAADNFILESEQTLGSPLELYDYQKDLHLRQANLNIEDNDEDKNLASKKVYLPLSLKEASTILSMYNITMQNYMKDIHTTINNNNGSPTNNHSCNNLKRLLVLCDGLDRNGIVCMSSLVSNNDFKNDNYNTNNNNIRDQQLVRVAVDSFVIKSKCYSFNMQEVPSVEQLLLGRLLTDCKRRQYTSTCLLYGSDKVEGHFNQVSVKFEWDDEEGSNALESPPIQATATLSIRIGDDMDGDAGGGDDDDDGDDVMMSNLSDDISSLQRLLRALEEEEVMWPVRNRDATARELVEKLIAEGSNSYSSQQQQPQQPPTSSDNNSNIETQQQHQQKSCKSFSLLKRFNMDFTDQLWDVMRDCSSYSELLSCFQCIFHALLSKQLQPMLSNTNRCTLADLIRQSYNGDVRRDVILWSKEEKPIILLAEMGLEKLKRDLLSAFIGSNMVNISQLAWYLCELETVGLNEKLEKLKRLAHVLRMNVLMGKKSLVPKAALFEILNKSLKHYEEVGDLVNPFQMQMSVLSIYDKIKKLSPTSWSCFVYGTTSFQQEIVGCVSFSKRQSFDHVKSDEILDSDDKSDKRSYYLTTVHQSINNY
The following text describes a protein:
Function:
Phosphorylates GarA. May play a role in metabolic regulation via control of the phosphorylation status of GarA. Plays a crucial role in the survival of mycobacteria within host macrophages, by blocking the intracellular degradation of mycobacteria in lysosomes. Required for intrinsic antibiotic resistance.
Subcellular Localization:
Cytoplasm. Cell membrane. Note=Also detected in growth media, suggesting that it can be translocated into host macrophages under specific conditions.
Domain:
Contains an N-terminal rubredoxin domain, a central kinase domain and a C-terminal TPR domain.
Sequence:
MAKASETERSGPGTQPADAQTATSATVRPLSTQAVFRPDFGDEDNFPHPTLGPDTEPQDRMATTSRVRPPVRRLGGGLVEIPRAPDIDPLEALMTNPVVPESKRFCWNCGRPVGRSDSETKGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQLKLIDLGAVSRINSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLREVVAQDTGVPRPGLSTIFSPSRSTFGVDLLVAHTDVYLDGQVHAEKLTANEIVTALSVPLVDPTDVAASVLQATVLSQPVQTLDSLRAARHGALDADGVDFSESVELPLMEVRALLDLGDVAKATRKLDDLAERVGWRWRLVWYRAVAELLTGDYDSATKHFTEVLDTFPGELAPKLALAATAELAGNTDEHKFYQTVWSTNDGVISAAFGLARARSAEGDRVGAVRTLDEVPPTSRHFTTARLTSAVTLLSGRSTSEVTEEQIRDAARRVEALPPTEPRVLQIRALVLGGALDWLKDNKASTNHILGFPFTSHGLRLGVEASLRSLARVAPTQRHRYTLVDMANKVRPTSTF
The following text describes a protein:
Function:
Involved in the processing and trafficking of GAS1 and PHO8 glycosylated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
Sequence:
MSEVAETWVDTWMAKLVNYDYKHFIRLVIIVGGYLLLRNIASRELAKKQLAAQVEKDKRDKEEKRSKDLIDKPDDAATAETTSFGWGKKTRRRVKRQQELFENALEEAKRRNQGLDPDSDADIEELLEE
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 1400 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MVSTPELKKYMDKKILLNINGSRKVAGILRGYDIFLNVVLDDAMEINGEDPANNHQLGLQTVIRGNSIISLEALDAI
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MTTGKDIELDCTPYQSIYETKTKLADVLSSNVDDLQIIFRAVPVDNSKCFKDLDITSGPALFFVSISNTHKQVEKPHKSASSRSNQKNDRKYQYLPPREPFYQPREEKVQNMIAILQELGFEKEMCAEALKAASYNCDRAAEYLLANSIPCDVCQDVDTLCEQRNKVCQEAVEQNVGDYSAKLEQLSPDQREAIKRLEANGFEKHLVIQVYYACEFNEENALNILSNMDTQ
The following text describes a protein:
Function:
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MDERSFELAESFVTPRYVQTGVESLHSVERTVRAIIAQRRCPEEGLHDCAIELIMQQLAVMDTNNFSIHVGAGEREGRVASVLVARRHYSLTHGIGRSGDICSDQPKAAGSSVMYKLVNHMMLDLLRQAGTPSLASAAVIPMATGMTIALALRSIFHHRVEELRFDSKGHTEEEQEKLHAGLRTRGDDSAVPRYVIWTRIDQKTALKCIELSGFVPMVVPLRRAPVLRRMQSKEGLGTAETLLHSYFLEAHVDDVAAAIERVGGPKHVLCVLSTTSCFAPRLPDDVVAIAKLCKALDIPYVVNNAYGVQSRTIMHKLDAAIRLGRVDLIVQSGDKNFLVPVGGAVLSGGKTAVARATSLYAGRASASPVIDLFITALSLGRSGFKKLWDTRYLLRRSLQNQLKGFAGARGELLLDEFDAQCDVDGASGDFVAAVPPSGEAGCDGVERPQRNDISFAITMRTVGSPSTAAAVGARLFRKGVTGPRVVLPSDNVTRLCGHSFRNYGMHTDETPSCPLLVLACGVGMTAEDVDGLMKRLGEVWPVEGV
The following text describes a protein:
Function:
Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.
Sequence:
MLEGYVLRCLSCGATYKPDPWLMRCPSCKGLLEPKLNDVEVSWEDFRGRKFGVWRYRELLPRVRYQVTMGEGGTPLIELKSNLFVKFEGANPTGSFKDRGMSVAISVAKEIGVKSVICASTGNTAASMSAYAARAGLKSFIVLPKGKVAKGKLAQASLHGATVVEISGSFDEALEAVIEASGKELGLYPLNSFNPWRLEGQKTLAYEISDELGVPDWVILPVGNAGNISALWKGFKELKSLGLIDRLPRLVGVQARGASPIVRAFREGRMEFFERPETVATAIRIGKPVNWPKALLALEESNGIATDVSDQEILEAQMMLGRMGIGVEPASAAPYAAYLNLLGREIGEDERVVLIATGHALKDPDIIPTPRPIEASSVEEAVEEIRRVIGRG
The following text describes a protein:
Function:
Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the endosome-associated recycling protein (EARP) complex. Important for neuronal function.
Subcellular Localization:
Cytoplasm. Note=The cytoplasmic localization is supported by the over-expression of an eipr-1-GFP fusion protein.
Sequence:
MSECLMFGMDCEARCMTSMTADEENICFLVGTNNIKNDKNQVNKLFMDPEASRLMSKTFRHPAGEVRAIAAHPTKSTILATCTADFSSLGGTHSITIWNIEEDKRTLETVSRLPTEQVMSCLEWEPNSMKCAAMTPFRPEIQLLNMENGPEIVQNLKIPLENEEDEMFSATWSPHHDGNMLGVTGGRTAWCIDCRTDNEYLKIRDAHIHRTISMDFNPNLQHVIATCGDDGYVRIWDTRSTSSALTSLHPHAHWVWSVRFHPVHDQLLLTGGSDASVVLSCAQSVSSEQQIEFRDDEEEEEDDDLVEKLQDGQLERIDEHEDSVYACAWSSADPWTFASLSYDGRMIVSNVSRKHKYALMQL
The following text describes a protein:
Function:
Plays a role in the sugar gustatory response.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKNSKYVQNCIFYAMKRPLLVAQIFGYFPLYGTNSDPTCLKFKWISFKTTYSVFTLFVTFFIAVCQLHKMIAVEMNILQMNYFVFLLCSILVNIAFIKLATEWPQLMKAWLKIELLVGNLGMRRNFRKKLDFIFTFITLLTIVEHLLMELSRAIDSVACSKTVSDGIRHYYVNVTFPHLFNGLVDYSLWKALIFQISNLQTTFGGTFGDTFIILLSMAFATRMKQSRTKIEALVKSHVKATTPWRKIREEQCSLLYLCTLLEQKISYLVLLSFCSNLYFVLVQLFSALKQMGDTLQKTYFFISFGILIFRIIFVSLSAASINEESRKILILLLSTPSELYSVEVERLTNQINYKAMAISGKNFFIITRGLILKIAGAVVTYELVLIQFNKKLLNEFDETSVQQLEILHNNTYWLC
The following text describes a protein:
Function:
Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B.
Subcellular Localization:
Nucleus.
Domain:
The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of UBP8 forms the 'catalytic lobe' of the SAGA deubiquitination module; The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.
Sequence:
MTEETITIDSISNGILNNLLTTLIQDIVARETTQQQLLKTRYPDLRSYYFDPNGSLDINGLQKQQESSQYIHCENCGRDVSANRLAAHLQRCLSRGARR
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric regions. Involved in heterochromatic gene silencing including the modification of position-effect-variegation (By similarity).
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Domain:
Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity); In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Sequence:
MATAEAQVNVNRNLQKQDLRNLEVSNLTPLSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLERLSEKKIKLLLKSKHQRHKYDIQQQKLLRILAERRKARAMTPLAPASVLAPSMETARPRLRSTSLNSLSPSNSSGYGSILGCDDSDQSSQLVLKPNVLKRRRSNCVQIPTPAAKRSRKNDGTTVKRRPKGEYIVEKIESVEVVQFQPVFFVKWLGYDVSANTWESYVNLSDCAEMEKFVERHLQLHQHYIAQITGELDTQLSDIPQTEDLKTISIAEIDAYDPLELQIDFILLAQYRAAASRSQREPERIGARALHRMQVRRSHFARRKQLIDLLLFEHRMNRVELPSPPIRVENNWDLDTIDSGFKYIQKNIIGEGVPKPQAGLVGCMCRHQSGEQCTASSMCCGRMAGEIFAYDRTTGRLRLRPGSAIYECNSRCSCDESCTNRVVQNGRKHPLVLFKTSNGSGWGVRTPQPLKKGVFVCEYIGEIITCEEANERGKAYDDNGRTYLFDLDYNTSRDSEYTVDAANFGNISHFINHSCDPNLAVFPCWIEHLNTALPHLVFFTIRPIKAGEELSFDYIRADNEEVPYENLSTAARVQCRCGAANCRKVLF
The following text describes a protein:
Function:
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. Also acts as a component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSTQYSILFKQEHAHEDAIWSVGWGKNSNDGSELVISGSLDDLVKVWKWSDERLELQSTLEGHQLGVVSVDVSPSGNIMASSSLDAHIRLWDLESGKQIRAIDAGPVDAWSVAFSPDSQHLATGSHVGKVNIFGVETGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYEVQHASLAATLSGHGSWVLNVAFSPDDTHFVSSSSDKSVKVWDVSARTCVHTFLDHQDQVWGVKYNKNGSKIVSVADDQEIHVYDCPI
The following text describes a protein:
Function:
Possible component of hydrogenase 4.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRQTLCDGYLVIFALAQAVILLMLTPLFTGISRQIRARMHSRRGPGIWQDYRDIHKLFKRQEVAPTSSGLMFRLMPWVLISSMLVLAMALPLFITVSPFAGGGDLITLIYLLALFRFFFALSGLDTGSPFAGVGASRELTLGILVEPMLILSLLVLALIAGSTHIEMISNTLAMGWNSPLTTVLALLACGFACFIEMGKIPFDVAEAEQELQEGPLTEYSGAGLALAKWGLGLKQVVMASLFVALFLPFGRAQELSLACLLTSLVVTLLKVLLIFVLASIAENTLARGRFLLIHHVTWLGFSLAALAWVFWLTGL