lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The FYVE domain is involved in the binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) which is required for the association to endosomal membranes; Both IUM domains are necessary for efficient binding to ubiquitin.
Sequence:
MSALWSAWGADAFTEQVEKATSEMLPVGSEDIALNLEICDQVRAKQVPAKQAMQVLKRRLSHKNPNVVLLALGLTDICIKNGGDHFLQQVASREFMDNLLSVLRNPAGVNNDVKNKALGLIQNWSQIAQAKPAHMSYITDIYQQLKSDDQFDFPPLDPNAAAVAAALVETLTAPEWVDGDVCMRCRTAFTTFNRKHHCRNCGNVFCQQCSSHNMALSWFGIGQDVRVCDGCYARKGPPKNALKLSRSKSASSSSPSTSSSKHVPSGRGASSSSSHHRSATLGAKSKRSARQKEEDDIALAIKLSLEASAETAPQRSRPTSFATPSQPSAATLSAHKPPNGRVLEGTDADNDPDLAAAIAASLRDWAPPQPSAPFGLNDTAGPAPTSATDASQSANSHLPLPPSLDLAPQDVDNILTFSQTVQAQQAHNQRTGMVGAPLPASVQAMYEKASSARPRMARNLEEGHRRHNVLVSMHDKLTEAVHLYDRLLDAQMTRPAQAYAPHGYAQATYPAASHQGYGYGYQPSIPLHESAYAAQQAGPSSLYLQTPQSHAGPLSDYSGTPAPWLPQQQQQLQPQPQTQPPQYEQPPYQPTQQPYAPHAAQPQYARDQPPPQHSAQQQQQQQQQQQQQQQQQQQQKQQQKQQQKQQQQQHLNPQYQQYASPNPVSNHANAVYADPNQALSPTSTVANTAQYAAYDYSGATIDHASHTQANSVAHTTAPAYAQTNGAASMSSAEPLASQPPDTLSVRTQGIMGGAPSNVSTVVPADKSQVINDGKGNESISTSHLPEDASISSRNGWSAVPTPALTEGALERTATGTDVQHQRQQQSYHQQQAPVKADTSYLPLFPVAPHPDNGFGPDRNAAEATSPMASPYTNAPSSAGMWQNPAGTGVTSASANANANANANADAAATESPLIEF
The following text describes a protein:
Function:
Activator of CDK5/TPKII.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPVGKGGKGESRLKRPSVLISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDPPDGGGTAKPLAVPVPTVPAAAATCEPPSGGSAAAQPPGSGGGKPPPPPPPAPQVAPPVPGGSPRRVIVQASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAASGGGPPSGGAPAASSAARDSCAAGTKHWTMNLDR
The following text describes a protein:
Function:
Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MVSEAEFLASYPQKCPAGSLPGTPGNTDEAQEGALKQLRSELEAAGFKERLDDSTLLRFLRARKFDVALAKEMFENCEKWRKEYGTNTIMQDFHYDEKPLVAKYYPQYYHKTDKDGRPVYFEELGAVNLTEMEKITTQERMLKNLVWEYESVVNYRLPACSRAAGYLVETSCTVMDLKGISISSAYSVLSYVREASYISQNYYPERMGKFYLINAPFGFSTAFRLFKPFLDPVTVSKIFILGSSYQSELLKQIPAENLPSKFGGKSEVDEAAGGLYLSDIGPWRDAKYIGPEGEAPEMFSMK
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of phosphoserine (P-Ser) in vitro. Also catalyzes the dephosphorylation of phosphothreonine (P-Thr) in vitro.
Sequence:
MSASQTSDVPTLLVKIFGKDRPGITAGLFDTLAAYSVDVVDIEQVVTRGRIVLCALVTEPPRGLEGDLRATVHSWAESLKLQAEIISGIGDNRPRGFGRSLVTVLGHPLTAEATAAIAARITESGSNIDRIFRLAKYPVTAVEFAVSGVETEPLRTALATEAAALGVDIAVVAAGLHRRAQRLVVMDVDSTLIQDEVIELFAAHAGCEDEVAEVTAAAMRGELDFEQSLHARVALLAGLDASVVDKVRAEVRLTPGARTLIRTLKRLGYQVGVVSGGFTQVTDALQEQLGLDFAQANTLEIVDGRLTGRVTGEIVDRAGKARLLRRFAAAAGVPLSQTVAIGDGANDLDMLNAAGLGVAFNAKPVVREAAHTAVNVPFLDTVLYLLGITREEVEAADTLADDLGDGPGRP
The following text describes a protein:
Function:
Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shows a cytoplasmic localization when co-expressed with MAP3K12.
Sequence:
MAAAAELSSSSGSERSLEQCSSPLLTREVLCEVFRSLHTLTRQLNLRDDVVKITIDWNRLQSLSASQPALLLTALEQHVLYLQPFLAKLQSLMKENSTATEIRQTEAETKSELRAIHPTEDLQDEGKPKDCDVGDVKKTQNLFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAVFTPYPGFKSHVKVSRVVNTYGPQTRPEGIAGSGHKPTGMLRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVNFSGKRRKVQPPQQNYSLAELDEKISALKRALLRKSREADSMAAHLP
The following text describes a protein:
Function:
Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. Does not bind DNA. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984,. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2. Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion; [Isoform 3]: Exhibits dominant-negative suppression of MHC class II gene expression.
Subcellular Localization:
Nucleus. Nucleus, PML body. Note=Recruited to PML body by PML.
Domain:
The acetyltransferase domain is necessary for activation of both class I and class II transcription; The GTP-binding motif doesn't confer GTPase activity but promotes nuclear localization.
Sequence:
MRCLAPRPAGSYLSEPQGSSQCATMELGPLEGGYLELLNSDADPLCLYHFYDQMDLAGEEEIELYSEPDTDTINCDQFSRLLCDMEGDEETREAYANIAELDQYVFQDSQLEGLSKDIFKHIGPDEVIGESMEMPAEVGQKSQKRPFPEELPADLKHWKPAEPPTVVTGSLLVGPVSDCSTLPCLPLPALFNQEPASGQMRLEKTDQIPMPFSSSSLSCLNLPEGPIQFVPTISTLPHGLWQISEAGTGVSSIFIYHGEVPQASQVPPPSGFTVHGLPTSPDRPGSTSPFAPSATDLPSMPEPALTSRANMTEHKTSPTQCPAAGEVSNKLPKWPEPVEQFYRSLQDTYGAEPAGPDGILVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPSTLTGLYVGLLGRAALDSPPGALAELAKLAWELGRRHQSTLQEDQFPSADVRTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGALWLALSGEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSRISLR
The following text describes a protein:
Function:
Displays ATPase and GTPase activities.
Sequence:
MTKKQLHLVIVTGMGGAGKTVAIQSFEDLGYFTIDNMPPALLPKFLQLVEIKEDNPKLALVVDMRSRSFFSEIQAVLDELENQDGLDFKILFLDAADKELVARYKETRRSHPLAADGRILDGIKLERELLAPLKNMSQNVVDTTELTPRELRKTLAEQFSDQEQAQSFRIEVMSFGFKYGIPIDADLVFDVRFLPNPYYLPELRNQTGVDEPVYDYVMNHPESEDFYQHLLALIEPILPSYQKEGKSVLTIAMGCTGGQHRSVAFAKRLVQDLSKNWSVNEGHRDKDRRKETVNRS
The following text describes a protein:
Function:
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
Sequence:
MKETQEIKSMFDKIVSRYDFLNRLLSFWQDILWRKKMATEAVNKETQLVLDLAVGTGDSAKELLKKGAKVIGVDISFEMLRIARGKIQNDFTPVSASAYELPFRDKIFDAVTCAFGIRNMHETEVALREIHRVIKDNGKIIILEFSLPSGFVRKPYLFYLKKIVPSIASLFSVKTAYEYLGSSIEGFYKPEDFTELLQNCGFKNIKTHSLSFGVVYLYVGEKI
The following text describes a protein:
Function:
Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity).
Miscellaneous:
MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia.
Sequence:
MITFLPIIFSSLVVVTFVIGNFANGFIALVNSIEWFKRQKISFADQILTALAVSRVGLLWVLLLNWYLTVLNPAFNSVEVRTTAYNIWAVINHFSNWLATSLSIFYLLKIANFSNFIFLHLKRRVKSVILVMLLGPLLFLACHLFMINMNEIVRTKEFDGNMTWKIKLKSAMYFSNMTVTMVANLVPFTLTLLSFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVISFLLLCAIYFLSIMISVWSFGSLENKPVFMFCKAIRFSYPSIHPFILIWGNKKLKQTFLSVFWQMRYWVKGEKTSSP
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MESVAFEDVAVNFSLEEWAMLNPSQKNLYKDVMQETLRNLASIGSSLEHHIIENIYRNSWKKLSGQVVEGLYDCKDDHQCAEIFDFTTHSIVNQNSLPGVYICENSGCATVVIGHLSLSVLLKPDPKHESCEDQEYGKELYNMEYGAPSSSLTSFENYESTYTVERIYKTERCDEDYRYGQNVEKTFTEEKPFECKQCGKCFSSSRYFRRHERRHRAKKCYICKQCGKAFAFPTYLQTHERIHTGEKPYVCLQCGKTFAHSRSLKTHKRTHSVRDLFVCNYCGKTLRHYSSLQIHTRIHTGEKPYVCKPCGKAFITYRSFRIHERIHTGETPYECKQCGNTFMRWIQLRKHEIIHSGVKPYACKLCGKSFTCSGSLRTHERIHTGERPYVCDQCGYSFTRLNSLLRHKITHTGEKPYVCNHCGKTFPRSASLQRHVKIHTEEKPYVCKQCGVAFPSSADLLEHEQTHIDEKPYICEQCGNAFVLWSQFQKHKALHAVPVSYVCKQCGKSFTSSRSLKTHERIHTGEKPYECKQCGKTFLWSYSLQRHEKTHTDGKVHVCKQCGETFPYDSHLQVHEKLHFDDEPFNCKYCGKPFFTLNHLHRHELLHTTLDSSVF
The following text describes a protein:
Function:
Unlike some other CBS-domain containing proteins does not seem to bind AMP.
Miscellaneous:
MISCELLANEOUS: Has been detected extracellularly but no signal sequence is predicted by bioinformatic programs.
Subcellular Localization:
Secreted. Note=Not seen to be associated with the cell wall.
Sequence:
MTTARDIMNAGVTCVGEHETLTAAAQYMREHDIGALPICGDDDRLHGMLTDRDIVIKGLAAGLDPNTATAGELARDSIYYVDANASIQEMLNVMEEHQVRRVPVISEHRLVGIVTEADIARHLPEHAIVQFVKAICSPMALAS
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAKSSEFVNEESSEDESSVSSIEDQHSSKEPEQSVESNNHGESNAQEDVAEIAGLEKVQGKPVLTTNDLKKESNVFLVRLPPGMSADQISQLKVGSKPTVELKQENENTYQIREESTSSVRVFLPDEQGSYTSNEIKTGYVITETPKISQNIDTGITIPTQAPLVPQRKNLRQHFRPIGDAVGPESEPEAEPKSGIKEHILQETGDATVEELQNKGKEKQKELKKGKREKKDEEEKPKKKKQKKSSKKEKN
The following text describes a protein:
Function:
GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTAKPKSSGKSRSSTSAGPVKQHVKGENFYRDAKKAKTVKLLSKDGGKAIRDRDGKIIKAAAFQSSDAPNGRIQPDRRWFGNTRVISQKALDHFRTSLAQKQADPYSVILKQNKLPMSLLQSDAEKAAQGGKGMKVDLVTAEPFEQTFGPKQRRKRPRLSTAGTFEELVKEAEDLNSNKKSKSLAGEKLPPVDGLGKFIKGGEEQLEEADSQEDDEQHNVAVDYILSAGTSKRIWSELYKVIDSSDVILHVLDARDPLGTRCLSVENYLQKEKRGKKMVWILNKVDLVPGWVASRWVKYLSKFHPTIAFHASINNSFGKGSLIQLLRQFSSLFSDRKQISVGFIGYPNVGKSSIINTLKKKKVCNVAPIPGETKVWQYITLMRRIYLIDCPGIVPPSAKDSEAAKVLKGVVRVEHLSCPADHIPPLLDRIRPEYMVRTYGIQEWQDSEDFLTQIARKSGKLLKGGEPDLRTVATCVLNDWIRGKIPYFVPPPTQTPGFKTQNSPEEKDQSQLITEQRSEEGKQTKKSGREDGEDKVGVIKGVTQPLHQIVRTNKFLEDDEIGEFEYADEEGEEGAERLAKSGSKGEAAVTEDIDSEEEEKDEDDLDLSDSGEWSGIGSEDEDEEELCYEDLIKAPTAKSTASSNALASDLNDDDDDDEDLDIVLDETEPIRQTGQVAKASKAAGKRKGNQEEEVDLDGSVDRRNNKKTKEPRMTTNKKKSENFFTNANVKNKNRNRKVPKLNTTKKKK
The following text describes a protein:
Function:
G- protein coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization. May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum. Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNDSRWTEWRILNTSSGILNVSERHSCPLGFGHYSAVDVCIFETIVIVLLTFLIIAGNLTVIFVFHCAPLLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLLHYSTGIHESLTCQVFGYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIILIWIYSCLIFLPSFFGWGKPGYHGDIFEWCATSWLTSAYFTGFIVCLLYAPAALVVCFTYFHIFKICRQHTKEINDRRARFPSHEAAASRDAGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNCVIYSLSNSVFRLGLRRLSETMCTSCMCVKDKEARDPKPRKRANSCSI
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore.
Sequence:
MSESLDNSAINQLIPEIFDQMRHNAARTRDAKKPSAMVEESGSITTQSLLRELETLDKVIATIRSIDSVVKGALPSHMNKIHHVCKSTNKMLDNWINIQSQAGYAHHIMDSRTGSKTGSNSNEEVVEQYKQEIAELQKSIKMEEDKLIPAQVKGNGNGPTGQRLYGNSYRQPTGRVTKATALRNARNRPSGIPQISSRLTRPTASSNLKRQR
The following text describes a protein:
Function:
Negative regulator of the cell cycle acting downstream of the cAMP-dependent protein kinase. Part of a glucose-sensing system involved in growth control in response to glucose availability. Phosphorylates POP2.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between both compartments in response to glucose.
Sequence:
MNSSNNNDSSSSNSNMNNSLSPTLVTHSDASMGSGRASPDNSHMGRGIWNPSYVNQGSQRSPQQQHQNHHQQQQQQQQQQQQNSQFCFVNPWNEEKVTNSQQNLVYPPQYDDLNSNESLDAYRRRKSSLVVPPARAPAPNPFQYDSYPAYTSSNTSLAGNSSGQYPSGYQQQQQQVYQQGAIHPSQFGSRFVPSLYDRQDFQRRQSLAATNYSSNFSSLNSNTNQGTNSIPVMSPYRRLSAYPPSTSPPLQPPFKQLRRDEVQGQKLSIPQMQLCNSKNDLQPVLNATPKFRRASLNSKTISPLVSVTKSLITTYSLCSPEFTYQTSKNPKRVLTKPSEGKCNNGFDNINSDYILYVNDVLGVEQNRKYLVLDILGQGTFGQVVKCQNLLTKEILAVKVVKSRTEYLTQSITEAKILELLNQKIDPTNKHHFLRMYDSFVHKNHLCLVFELLSNNLYELLKQNKFHGLSIQLIRTFTTQILDSLCVLKESKLIHCDLKPENILLCAPDKPELKIIDFGSSCEEARTVYTYIQSRFYRAPEIILGIPYSTSIDMWSLGCIVAELFLGIPIFPGASEYNQLTRIIDTLGYPPSWMIDMGKNSGKFMKKLAPEESSSSTQKHRMKTIEEFCREYNIVEKPSKQYFKWRKLPDIIRNYRYPKSIQNSQELIDQEMQNRECLIHFLGGVLNLNPLERWTPQQAMLHPFITKQEFTGEWFPPGSSLPGPSEKHDDAKGQQSEYGSANDSSNNAGHNYVYNPSSATGGADSVDIGAISKRKENTSGDISNNFAVTHSVQEGPTSAFNKLHIVEE
The following text describes a protein:
Function:
Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
Sequence:
MRISWMIGGAQGSGVDTSANIFGNAVAASGYYIYGNREYYSNIKGRHSYFNLTISDKPPRSIAQQIEILTSFDAETIFQHFNEVKDVLIYSTEVENTKAEQVQSMEPEITEHVVKFLKEKGYGTTVKDVINYLKKEKGVKVIPIDYMEILKKVADQAKVQLSVADRARNTIAIAASYKLLGLKEQYLINSITRTFRQEVFAKINTIAAQLAMQQIQPMYNLPELPNNEEKINLDGNTAAAIGKIYGGLRFQSYYPITPASDESVFIEAHQTVFTVDPKTGEKRKSTIVVVQAEDELAAINMASGAALTGVRAATATSGPGFSLMVEGMGWAGMNEVPVVITYYIRGGPSTGQPTRTSQADLMFALNAGHGEFPRIVIASGDHVEAFHDGTWALNLAQKYQTPVIHLVDKALANSYSIIPKKTLGMENIRIEKGKIVINTNTPELKRFEITEDGISPFAPLGTARVHYTGDEHDEYGFIAEASENREKMYEKRIKKLMTADKEIPEESRVNVYGNTDSKVAIITWGSPKGAILDAMEELENEGIKPMLIQIRMFSPFPKNLMRKLLNGKEFIIDVESNYFGQAGEVLKLNTGIEPTHYILKWNGRPMMRDEVKEGIKAVVQKGERRVVLHGGA
The following text describes a protein:
Function:
Structural component of the virion that acts as a cement protein on the capsid exterior and which mediates the interactions between the hexons, including the peripentonal hexons, and reaches all the way to the penton vertices. Two hexon linking proteins IIIa, one from each facet, stabilize the unique edge interface between a pair of facets. As the virus enters the host cell, hexon linking proteins IIIa are shed concomitant with virion acidification in the endosome. During virus assembly, seems to play a role in the serotype specificity of the packaging of viral DNA via its interaction with packaging protein 3.
Miscellaneous:
MISCELLANEOUS: All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Subcellular Localization:
Virion. Host nucleus. Note=Surrounds the border of each facet on the capsid exterior. Present in around 60 copies per virion.
Sequence:
MMQDATDPAVRAALQSQPSGLNSTDDWRQVMDRIMSLTARNPDAFRQQPQANRLSAILEAVVPARANPTHEKVLAIVNALAENRAIRPDEAGLVYDALLQRVARYNSGNVQTNLDRLVGDVREAVAQRERAQQQGNLGSMVALNAFLSTQPANVPRGQEDYTNFVSALRLMVTETPQSEVYQSGPDYFFQTSRQGLQTVNLSQAFKNLQGLWGVRAPTGDRATVSSLLTPNSRLLLLLIAPFTDSGSVSRDTYLGHLLTLYREAIGQAHVDEHTFQEITSVSRALGQEDTGSLEATLNYLLTNRRQKIPSLHSLNSEEERILRYVQQSVSLNLMRDGVTPSVALDMTARNMEPGMYASNRPFINRLMDYLHRAAAVNPEYFTNAILNPHWLPPPGFYTGGFEVPEGNDGFLWDDIDDSVFSPQPQTLLELQQREQAEAALRKESFRRPSSLSDLGAAAPRSDASSPFPSLIGSLTSTRTTRPRLLGEEEYLNNSLLQPQREKNLPPAFPNNGIESLVDKMSRWKTYAQEHRDVPGPRPPTRRQRHDRQRGLVWEDDDSADDSSVLDLGGSGNPFAHLRPRLGRMF
The following text describes a protein:
Function:
Required, indirectly, for activation of ribonucleotide reductase through the degradation of the protein spd1, thereby supplying deoxyribonucleotides for DNA replication and repair. Also has a role as a scaffold for assembling ubiquitin ligases. Component of the Clr4 methyltransferase complex (ClrC) which contributes to the establishment of heterochromatin by specifically methylating histone H3 to form H3K9me. ClrC preferentially ubiquitylates H3K14 and ClrC-mediated H3 ubiquitination promotes clr4 methyltransferase activity for the methylation of H3K9. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome.
Sequence:
MPPEAKRIVVKGFDPRKSRQRQETYYVTMIDRLNMALQVVMAGLGLKTGYQELYSGVENLTRADQASRCFNILQHHMSSGIQLLKDSAESFIQLEGTETDTNACTVVVGCWNKWLERVEIVQNIFYYMDKTFLSHHPDYPTIEELSLSLFREKLMAVKNIQIPFLNSLLQSFENLHSSKSTDHAYLQDAMLMLHRTEMYSSVFVPMYLVMLSRFYDTESSQKIQELPLEEYLEYAMSSLEREDAYVEKFDIVRDKKSIRETVQRCLITSHLDTLTKGISQFIEKRDAHSCKLLYALLQFNHETEYLIQPWSDCLVDVGFKLVNDESKDDTLVQELLSFHKFLQVVVDESFLHDETLSYAMRKAFETFINGAKGSQREAPARLIAKYIDYLLRVGEQASGGKPLKEVFSEILDLFRYIASKDIFEAYYKLDIAKRLLLNKSASAQNELMLLDMLKKTCGSQFTHSLEGMFRDVNISKEFTSSFRHSKAAHNLHRDLYVNVLSQAYWPSYPESHIRLPDDMQQDLDCFEKFYLSKQVGKKISWYASLGHCIVKARFPLGNKELSISLFQACVLLQFNNCLGGEGISYQDLKKSTELSDIDLTRTLQSLSCARIRPLVMVPKSKKPSPDTMFYVNEKFTDKLYRVKINQIYLKEERQENSDVQEQVVRDRQFELQASIVRVMKQKEKMKHDDLVQYVINNVKDRGIPLVSDVKTAIEKLLEKEYLEREDNDIYTYVT
The following text describes a protein:
Function:
Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the decarboxylation of N1-(3-aminopropyl)agmatine to yield spermidine and urea. It cannot use agmatine as substrate.
Miscellaneous:
MISCELLANEOUS: In T.thermophilus, the biosynthetic pathways of spermidine operates via N1-aminopropylagmatine without the production of putrescine.
Subcellular Localization:
Cytoplasm.
Sequence:
MRLVFGEKDTPYEEARVVVLPVPYDLSLSFLPGARRGPEAILLASRELEPFLLELGAAPEEVGIHAAEPVPWVAGMAEESHRLIREEALRHLRAGKWVVALGGDHSVTHPLVQAHREALGDFSLLHVDAHADLYPEWQGSVYSHASPFYRLLTEGFPLVQVGIRAMDRDSLRLARKKGVALFPAHRIHREGLPLDEILRALGKRVYISLDFDALDPSLMPSVGTPLPGGLSYRQVVDLLEAVFREKEVVGMDFVELSPNGQFHAEMTAAQLVYHAIGLKGLQAGWLSREVDHI
The following text describes a protein:
Function:
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
Sequence:
MPKKLTKPRPRARFYPYLIPAFYKISSYLTVLEVIHSEKEPAYVSPRCKKLNLYSEGATTLKKLHSGVTLTLRTRASDGGSSPGLKPARGAVLGGAQRPGMERGMGTFGGCPGLLQRRQDRESVGQRSRARHQMGLQGHPGGVAPPDSIWEQTGGEFECVASLEGHENEVKSVAWNAGGNLLATCSRDKSVWIWEAQPGNEYECVSVLQGHSQDVKMVRWHPTRDLLVSASYDDTIKVWAEDGDEDDWRCVQTLSSAAQGHTSTVWGVAFDSTGDRMVSCSDDLTLKVWDTHTDPTTSMGAGAGAWKHVSTISGYHERTIFSVDWSRMNGLIASASGDDAIRIFADDEEPPSTTGQPTFSQVAKKEKAHSTDVNCVRWHPTDPRLLASASDDMCVKIWELRGRSESFPNGGSANGSKDVHL
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and the nucleus.
Sequence:
MPFLGQDWRSPGQSWVKTADGWKRFLDEKSGTFVSDLSSYCNKENLFNSLNYDVAAKKRKKDIQNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQQNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETTLHWQQQLNSIQISRPAFKGLTITDLPVCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKRLCQYHFSERQIRKRLILSDKGQLDWKKMYFKLVRCYPRREQYGVTLQLCKHCHILSWKGTDHPCTANNPESCSVSLSPQDFINLFKF
The following text describes a protein:
Function:
Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock. Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities and for ciliary localization of HYDIN and SPAG6 in ependymal cilia. Binds actin in intestinal epithelial cells (IECs), essential for IECs survival and contributes to formation of filopodia and lamellipodia in migrating IECs (By similarity). Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia (By similarity).
Miscellaneous:
MISCELLANEOUS: Radial intercalation is a developmentally reiterated form of migration by which cells move in a direction orthogonal to the plane of the tissue from an inner layer to an outer layer.
Subcellular Localization:
Cytoplasm. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Apical cell membrane. Basolateral cell membrane. Cytoplasm, cytoskeleton, stress fiber. Cell projection, microvillus. Cell projection, lamellipodium. Cell projection, filopodium. Note=Also found at the apical tip of cilia. Present in the tails of developing and epididymal sperm, internal to the fibrous sheath and around the outer dense fibers of the sperm flagellum. Colocalizes with TJP1 and CGN at sites of cell-cell contact in intestinal epithelial cells (By similarity).
Domain:
The Calponin-homology domain mediates its binding to microtubules.
Sequence:
MESSVDEEALHQLYLWVDNIPLSRPKRNLSRDFSDGVLVAELIKFYFPKMVEMHNYVPANSLQQKLSNWGHLNRKVLNKLNFSVPDDVMRKIAQCSPGVVELVLIPLRQRLEERQRRQKLGVGSLQELAPQDSSGYMDMGLPQKVRGEGAPALGEQLREGRPLASRPPGYNQALQGDPSFVLQIAEKEQELLASQETVQVLQMKVKRLEHLLQLKNVRIDDLSRRLQQAERKQR