lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1 (By similarity). Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Endosome membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein.
Domain:
The MIT domain is required for endosomal localization, CHMP1B-binding, maintenance of ESCRT-0 stability and EGFR degradation; The rhodanese domain is sufficient for RNF41-binding.
Sequence:
MPAVASVPKELYLSSSLKDLNKKTEVKPEKTSTKNYIHSAQKIFKTAEECRLDRDEERAYVLYMKYVAVYNLIKKRPDFKQQQDYYLSILGPANIKKAIEEAERLSESLKLRYEEAEVRKQLEEKDRREEEQLQQQKRQEMGREDSGAAAKRSVENLLDSKTKTQRINGEKSEGAAAAERGAITAKELYTMMMDKNTSLIIMDARKIQDYQHSCILDSLSVPEEAISPGVTASWIEANLSDDSKDTWKKRGSVDYVVLLDWFSSAKDLLLGTTLRSLKDALFKWESKTVLRHEPLVLEGGYENWLLCYPQFTTNAKVTPPPRSRAEEVSVSLDFTYPSLEEPVPSKLPTQMPPPPIETNEKALLVTDQDEKLRLSTQPALAGPGAAPRAEASPIIQPAPATKSVPQVDRTKKPSVKLPEDHRIKSENTDQSGRVLSDRSTKPVFPSPTTMLTDEEKARIHQETALLMEKNKQEKELWDKQQKEQKEKLRREEQERKAGKTQDADERDSTENQHKAKDGQEKKDSKQTKTEDRELSADGAQEATGTQRQSKSEHEASDAKVPVEGKRCPTSEAQKRPADVSPASVSGELNAGKAQREPLTRARSEEMGRIVPGLPLGWAKFLDPITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKVKPQVPAERDREPSKLKRSYSSPDITQALQEEEKRRPAVTPMVNRENKPPCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKVTIGKINDQFAGSSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNEHLDDLQAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCRRRSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNSLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVRSSAAYILFYTSLGPRITDVAT
The following text describes a protein:
Function:
Carboxypeptidase that possesses the specificities of both mammalian Cpase A and B. Thus shows broad substrate specificity, being able to cleave Cbz-Gly-Leu, Cbz-Gly-Val, Cbz-Gly-Phe, Cbz-Gly-Lys and Bz-Gly-Arg in vitro.
Sequence:
MRRRARSILAVGALLIGGASFAPIAQAQPADPGTPDANEVRVFRADVTKEQVPLLLATGQDGHELGEQVPDRGTAAVELYLTGKQAGTLRKQGVDLTEHTLSTQAEKRVESAADGVFRPYSGSGGLREEILRTAQENPGLTKVVSIGKTVNGQDILALKLTKHAKKSRDGSKPSVLYMSNQHAREWITPEMTRRLMHHYLDNYKKDRRIREIVDSTELWFVLSANPDGYDYTFESTDNRLWRKNLRDVNGDGTISTGDGVDLNRNFAYKWGYDDEGSSPNPTSETYRGASPGSEPETKALDAFQKRIGFTYGINYHSAAELLLYGVGWQVATNTPDDVLYKALAGTPDNSAIPGYHPQVSSELYTTNGEADGHAANVNGMAMFTPEMSTCKTASDVDPDDQWNARDCQSGFNFPDDEKLIQQEFAKNVPFALSVAETAAHPDRPSSAVGLDAADFTPAPFTTSYARGADQEVSVVVRKSVRDKELKYRVNGGRTHDTALRPWRGGETYGGEDNLYFDEYRARVRGAGPGDRVEVWFTGERPRGTHDGDDRRGGSGKHGKRTESEHFTYTVAERPRADVLVVAEEGAKATQTQTYVDALKANGHRAAVWDVATQGAPDALGVLGHFGTVVHYTGAAVPGNATQLQLRAFLNEGGKLIEAGEQAGGDVDLGGGTLSDDFSQYYLGAYTRTATSGATGFTGSGKLDKADGTLGDAPGNPLDAAGAYSVTSDELDPGTYPQFASAGAGQFAGTVNPYGPYAGEWMAAAVHTDDAYKRLTRTVDLTGVTASERPTLRTQLLWDTERGYDHALVEAHTTGADDWTTLPEANGATGTAVPAECAAGFYLAGHPWLAHYLTLSDEGCAPAGTTGQWNSLTGSSGGWKQVEFDLSAYAGKSVELSIAYVTDPGSGGRGVLADEASLVVGGAATQTEGFETSLGAWQVSGPPAGSPAVLKDWTRTGTLFQTYGAVTTDDTVLLGFGLEHLAEPAARAALVRQALRALDE
The following text describes a protein:
Function:
G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMEKKYILYFLFLLPFFMILVIAETEEENPDDLIQLTVTRNKIMTAQYECYQKIMQDPIQQTEGIYCNRTWDGWLCWNDVAAGTESMQHCPDYFQDFDPSEKVTKICDQDGNWFRHPESNRTWTNYTQCNINTHEKVQTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSIVTIIHLTAVANNQALVATNPVSCKVFQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAVARRLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILVHYQGLLVSTIYCFFNGEVQAILRRNWNQYKIQFGNSFSHSDALRSASYTVSTISDGAGYSHDYPSEHLNGKSIHDMENIVIKPEKLYD
The following text describes a protein:
Function:
Antimicrobial peptide.
Subcellular Localization:
Secreted.
Sequence:
MFTLKKSLLLLFFLGTINLSLCEQERDADEEERRDDSEERDIEVEKRFLPLIASVAANLVPKIFCKITKKC
The following text describes a protein:
Function:
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
Subcellular Localization:
Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope.
Sequence:
MSQQHTLPVTLSPALSQELLKTVPPPVNTQQEQMKQPTPLPPPCQKVLGELPVEVPSKQEEKHMTTVKGLPEQECEQQQQEPQEQELQQQHWEQHEEHQKAENPEQQLKQEKAQRDQQLNEHLEEEKKLLDQQLNQELIKRDEQLGIKKEQLLELTEQQEGQLEHLEQQEGQLELPEQQEGQLEHLEQQEGQLKHLDQQGKQPELPEQQVAQLKHLEQQEGQLKHLEHQKGELQVPEEQVGQLKYLEQQEGQLKHLDQQEKQPELPEQQVGQLKHLEQQEGQLEHMEHQEGQLGLPEQQVGQLKQLEEQEGQPKHLEEEEGQLKHLVQQEGQLEHLVQQERQLEQQEGKVQHLEQQVEQLKHLEEQEGQLKHLEQQQGQLEVSEQQVGQPKHLEQEGKQLELPEQQEGQLKHLEKQEAQLELPEQQVGQPKHPEQQEKQLEHPEQQEGQLKHLEQQEGQLKDLEQQKGQLEQQQGQLEQPVFAPAPGQVQDIQPVLPTKGEALLPVEQQQQKQEVQWPPKHK
The following text describes a protein:
Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAAMMSVCRNFGKVGLHSRLILGNPCLAALSKKNIIFYENKIVPVSQNALHSVKNFTVGPKALAETASCKSADDHTKLWTLERGLALALVPLVPAAFLFPSAAMDYLLAISFTLHAHWGLETIVVDYMRPKVVGPALAKLGVAVVYGISVFTLGGLFYFNYSDVGIVNAIKMFWKL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MGPGRRGNGIGGPGAPRLGGLRRGGRRGGRQGVAAPLGHGRPRLAGRRRGGPPASGKEPSDSGLPRGRRRGSRQQWQQSRPPGDLGVAPQAFQWARAGGRGSGAGRAGGEGVDAGRGVPELQHRGGGGEPGRWQWGGRRQRSSSRRSGGEGGEEAEGSGVGAGEGETVQHFPLARPKSLMQKLQCSFQTSWLKDFPWLRYSNDTGLMFCGWCQTTPEDVGSVDLPQVGHDELSRGTRNYKKTLLLRHHVSTEHKLHEANAQVLGSQACVTVDGSAVDKPDASEGCLLVGNESEIPSEEGYCDFNSRPNENSYCYQLLRQLDEQRKKDILCDVSIVVSGKIFKAHKNILVAGSRFFKTLYCVSNKESPNQNNTTHLDIAAVQGFSVILDFLYSGNLVLTSQNAIEVMTVASYLQMSEVVQTCRNFIKDALNISIKSEAPESVVVDYNNRKPVSRDGLTSSRDQKIASFWATRNLTNLASNIKIENDGCNVDEGQIENYQMNDSNWVQDGSPELAENESQGKTKVFIWNNMASQETGKARRKNQTTKRFVYNIPPNSETIVEDCSVLQPPVAYPEENKALLIKEEPVSDLDGALLSGPDGDRTMNTNLLAEACSSQDAGDAAGASHDFKYGLMPGTSSDFKYGLLPSTSNDFKYGLLPGAPNDFKYGLLPESWPTQEPWENGDSSLIMNKLKCPHCSYVAKYRRTLKRHLLIHSGVRSFKCEICGKMFTRREHVKRHSLVHKKDKKYKCMVCKKIFMLAASVGIKHGSRRYGVCMDCVDKSQPGGQESIDQGQDTEFPRDEEYEENEGVEPDEELAEDGQDQSDAPRWDEPGGAYVSG
The following text describes a protein:
Function:
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKRGHKKPRKDPGVPNSAPFKEALLREAELRKERLEELKQQQKLDRQKELEKKRKLETNPDIKPSNVEPMEKEFGLCKTENKAKSGKQNSKKLYCQELKKVIEASDVVLEVLDARDPLGCRCPQVEEAIVQSGQKKLVLILNKSDLVPKENLESWLNYLKKELPTVVFRASTKPKDKGKITKRVKAKKNAAPFRSEVCFGKEGLWKLLGGFQETCSKAIRVGVIGFPNVGKSSIINSLKQEQMCNVGVSMGLTRSMQVVPLDKQITIIDSPSFIVSPLNSSSALALRSPASIEVVKPMEAASAILSQADARQVVLKYTVPGYRNSLEFFTMLAQRRGMHQKGGIPNVEGAAKLLWSEWTGASLAYYCHPPTSWTPPPYFNESVVVDMKSGFNLEELEKNNAQSIRAIKGPHLANSILFQSSGLTNGIIEEKDIHEELPKRKERKQEEREDDKDSDQEIVDEEVDENSSGMFAAEETGEALSEETTAGEQSTRSFILDKIIEEDDAYDFSTDYV
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLRQLRLTMDILGWIFLPWRRSISNIKDSPPPPPLASTFDDVIVDYEDPDYLPLPEYPVRPNEPLETRKQRLLYQSRKRGMLENDLLLSTFAAKHLQNFSAEQTAQYDQLINGVSNDWDIYYWATDVKPTPKEYDTEIMRLLKKHVKNAEGVTRLRQPDLNT
The following text describes a protein:
Function:
Involved in glycosylation steps downstream of mono-O-methyl-glycosyl-p-hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl-rhamnosyl-phenolphthiocerol dimycocerosate (mycoside B) during the p-hydroxybenzoic acid derivatives (p-HBAD) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MAAPMFSIIIPTLNVAAVLPACLDSIARQTCGDFELVLVDGGSTDETLDIANIFAPNLGERLIIHRDTDQGVYDAMNRGVDLATGTWLLFLGADDSLYEADTLARVAAFIGEHEPSDLVYGDVIMRSTNFRWGGAFDLDRLLFKRNICHQAIFYRRGLFGTIGPYNLRYRVLADWDFNIRCFSNPALVTRYMHVVVASYNEFGGLSNTIVDKEFLKRLPMSTRLGIRLVIVLVRRWPKVISRAMVMRTVISWRRRR
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Although this protein has evidently no mitochondrial targeting pre-sequence, it is efficiently transported into mitochondria; MISCELLANEOUS: Present with 3000 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MTVGIARKLSRDKAHRDALLKNLACQLFQHESIVSTHAKCKEASRVAERIITWTKRAITTSNSVAQAELKSQIQSQLFLAGDNRKLMKRLFSEIAPRYLERPGGYTRVLRLEPRANDSAPQSVLELVDSPVMSESHTVNRGNLKMWLLVKSVINDDANQLPHNPLTLQNLHKVAKFKAEAQLHGEIMLIKQVLLKEMSLPYDEALENERTQALLKEVYSSSLPKKTKKPSSYVMVPRP
The following text describes a protein:
Function:
Involved in the control of lateral root (LR) formation. Acts a positive regulator of early cell divisions involved in LR initiation, independently of ARF7 and ARF19-mediated auxin signaling.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MDTSRDDDFTFSKVSPPDSEVKDLASDVGSITLKDGLDQQKSNGLIWKDKSLPPKEETIGSLSFTVTDSSSSKKQSNESSETFKTPARKPITRTKVPFEKGYSQMDWLKLTRTHPDLAGLKGESNKRLIPMDEVKKHRTGDSMWTVLKGRVYNISPYMNFHPGGVDMLMKAVGRDGTLLFNKYHAWVNVDILLEKCLVGVLDDTKVKKQEP
The following text describes a protein:
Function:
Required for growth in low iron conditions.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast.
Sequence:
MLRLIVNYPLIPKISHRVCSNSSSKLGSYYDSSSIIKYGGISDVVGKKQELFLSVSVKAVEDKGNNGGGSMSFSGQSWDPSSEIEVPSDQRPVNEYSSLKEGMLYSWGELGPSEFFIRLGGLWLVTFTVLGVPVAAASFNPSREPLRFILAAGTGTLFLVSLIVLRIYLGWSYVGDRLLSAVIPYEESGWYDGQMWVKPPEVLARDRLLGSYKVKPVIKMLKQTLIGTGALLVSAFVLFVFATPVEDFFKTTLGSTENQPEVSISRTSNKFNIRKEQLLRLPVDVVTDDDLAAAAAEAADGRPVYCRDRYYRALAGGQYCKWEDLVK
The following text describes a protein:
Function:
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes. Modulates bradykinin receptor BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Induces susceptibility to atherosclerosis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane raft. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation.
Domain:
The Ig-like C2-type domains 2 and 3 contribute to formation of the complex with BDKRB2 and in regulation of its activity.
Sequence:
MRLRWTQGGNMWLGVLLTLQLCSSLEGQENSFTINSIHMEMLPGQEVHNGENLTLQCIVDVSTTSSVKPQHQVLFYKDDVLFHNVSSTKNTESYFISEARVYNSGRYKCTVILNNKEKTTAEYKVVVEGVSNPRVTLDKKEVIEGGVVKVTCSVPEEKPPVHFIIEKFELNVRDVKQRREKTANNQNSVTLEFTVEEQDRVILFSCQANVIFGTRVEISDSVRSDLVTVRESFSNPKFHISPKGVIIEGDQLLIKCTIQVTHQAQSFPEIIIQKDKEIVAHSRNGSEAVYSVMATVEHNSNYTCKVEASRISKVSSIMVNITELFSRPKLKSSATRLDQGESLRLWCSIPGAPPEANFTIQKGGMMMLQDQNLTKVASERDSGTYTCVAGIGKVVKRSNEVQIAVCEMLSKPSIFHDSGSEVIKGQTIEVSCQSINGTSPISYQLLKGSDLLASQNVSSNEPAVFKDNPTKDVEYQCIADNCHSHAGMPSKVLRVKVIAPVEEVKLSILLSEEVESGQAIVLQCSVKEGSGPITYKFYKEKENKPFHQVTLNDTQAIWHKPKASKDQEGQYYCLASNRATPSKNFLQSNILAVRVYLAPWKKGLIAVVVIAVIIAVLLLGARFYFLKKSKAKQMPVEMCRPAAPLLNSNNEKTLSDPNTEANRHYGYNEDVGNHAMKPLNENKEPLTLDVEYTEVEVTSPEPHRGLGTKGTETVYSEIRKADPDLVENRYSRTEGSLDGT
The following text describes a protein:
Function:
Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MPSNTPLPSSFDGDTDFYEENRWQKLTRRLKEEPLIPLGKSTHTLTLSPSPPSLHHPSTQKLTHPLTHPPGCILTTLALVGATRSIRAGDHNRTQRMFRARIYAQGFTLLAMVAGSMYWDSDRKKRKEFEGVLAEQKAKEKNEAWIKELEARDEEEKEMRRMRDERRRRAEGKSAASGLVVDAANAGAEEGEKTKNGIVDQMKGMVWGKK
The following text describes a protein:
Function:
Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2.
Subcellular Localization:
Cytoplasm.
Sequence:
MLHLLSKDEFNSTLKSFEEQTESVSWIIDLRLHSKYAVSHIKNAINVSLPTALLRRPSFDIGKVFACIKCNVKVSLDEINAIFLYDSSMAGMNRIYDLVQKFRRGGYSKKIYLLSNGFEAFASSHPDAIVSTEMVKESVPYKIDINENCKLDILHLSDPSAVSTPISPDYSFPLRVPINIPPPLCTPSVVSDTFSEFASHAEYPGFSGLTPFSIHSPTASSVRSCQSIYGSPLSPPNSAFQAEMPYFPISPAISCASSCPSTPDEQKNFFIVGNAPQQTPARPSLRSVPSYPSSNNQRRPSASRVRSFSNYVKSSNVVNPSLSQASLEIIPRKSMKRDSNAQNDGTSTMTSKLKPSVGLSNTRDAPKPGGLRRANKPCFNKETKGSIFSKENKGPFTCNPWGAKKVSPPPCEVLADLNTASIFYKFKRLEEMEMTRSLAFNDSKSDWCCLASSRSTSISRKNRYTDIVPYDKTRVRLAVPKGCSDYINASHIDVGNKKYIACQAPKPGTLLDFWEMVWHNSGTNGVIVMLTNLYEAGSEKCSQYWPDNKDHALCLEGGLRISVQKYETFEDLKVNTHLFRLDKPNGPPKYIHHFWVHTWFDKTHPDIESITGIIRCIDKVPNDGPMFVHCSAGVGRTGTFIAVDQILQVPKNILPKTTNLEDSKDFIFNCVNSLRSQRMKMVQNFEQFKFLYDVVDYLNSGVNQASKPLMT
The following text describes a protein:
Function:
Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. The neuropeptide FF potentiates and sensitizes ASIC3 cation channel.
Subcellular Localization:
Secreted.
Sequence:
MDARQAAALLLVLLLVTDWSHAEGPGGRDGGDQIFMEEDSGAHPAQDAQTPRSLLRSLLQAMQRPGRSPAFLFQPQRFGRNTRGSWSNKRLSPRAGEGLSSPFWSLAAPQRFGKK
The following text describes a protein:
Function:
Functions as a soluble gibberellin (GA) receptor. GA is an essential hormone that regulates growth and development in plants. Binds with high affinity the biologically active gibberellin GA4, but has no affinity for the biologically inactive GAs. In response to GA, interacts with specific DELLA proteins, known as repressors of GA-induced growth, and targets them for degradation via proteasome. Seems to be required for GA signaling that controls root growth, seed germination and stem elongation. Partially redundant with GID1A and GID1B.
Subcellular Localization:
Nucleus.
Sequence:
MAGSEEVNLIESKTVVPLNTWVLISNFKLAYNLLRRPDGTFNRHLAEFLDRKVPANANPVNGVFSFDVIIDRQTNLLSRVYRPADAGTSPSITDLQNPVDGEIVPVIVFFHGGSFAHSSANSAIYDTLCRRLVGLCGAVVVSVNYRRAPENRYPCAYDDGWAVLKWVNSSSWLRSKKDSKVRIFLAGDSSGGNIVHNVAVRAVESRIDVLGNILLNPMFGGTERTESEKRLDGKYFVTVRDRDWYWRAFLPEGEDREHPACSPFGPRSKSLEGLSFPKSLVVVAGLDLIQDWQLKYAEGLKKAGQEVKLLYLEQATIGFYLLPNNNHFHTVMDEIAAFVNAECQ
The following text describes a protein:
Function:
May be a signaling molecule that mediates inductive activities of the embryonic midline. Able to dorsalize mesoderm.
Miscellaneous:
MISCELLANEOUS: 'Kiel' means keel in English. As the expression in the central nervous system (CNS) resembled a keel of ship, the gene was named Kielin.
Subcellular Localization:
Secreted.
Sequence:
MNTLLWTILLPLLFSFCVCQQPEHQDLEMSVQYYDDNVIDLLEALNVTRSVKGVTKAKGSDPASPAWKFRQRVPHLTLPRDYSVYLLSTTQESLGLHFVAKQAKNNRGTLVAFLSPAATKIDGRPLLRLISDTHTDQLYFEYRTAQTMEPASLHFPGSSPFSGSQWARVALNVNTHKVTLFLDCEEPVVFGKEGAEEMLSLILPLDLEITFASTPSDKESKFLGYWQTAEISPTGFTRRPWHCENRSDSLPLPYSLSGERQMEDEEIQREPRAPDLSDTDHYQQQQSEVPAQLLAKDDRLQRLEEAVKGLTNMIDMIKSQNADLQARVIALESCECRRSTCVWEDKEYQDSETWKKDACNICVCVGGSVTCSVRKDWPQCLGCFHEGRNYNNKDIFSVGPCMSCICQSGEVSCTPKLCPPVTCSDPVTLPNECCPLCATGCSDGHKEGDTWRKDTCTTCTCQNGTISCEREQCPELTCLKRHTPPGQCCAKCQQGCEYEGLIYRNGDYFLSQSNPCVNCSCLNNLVRCLPVQCPLPACTNPVPIPGQCCPSCPVCELDGHPLIPGQNVTTKDGCRLCSCQDGKVQCTESVQCPHICTHGVRSNSCCLDCSACEMHGDIIPNGLTFQGNMDPCESCTCQDGNVHCVRVSCPELSCVLHEKIPGECCSQCQSCMDGTVKRKHGEEWKPQGDPCQSCRCLEGRVQCRKRHCAALCRNPLPPRPGTCCPMCDGCLYNGRSYLNGQPVRSTDQCNRCFCENGNVQCEPIACPQAPCRNPVRRTGECCPRCEGCEYDSRHFAEGVVFTTAHDPCLQCTCLSGEVSCEHLDRKCPPSQCSHPGKAAGQCCPSCDVCDFEGILYTDRQTFQPPGHGPCLKCFCTIGNVRCVEETCPPAPCPNPVRDPEQCCPVCKVCVQDGVEFLEGIEWELDGNPCSSCTCRNGDTVCGVSECPPVSCLHPTRREGECCPVCDSCSYNQRLYSNEQIFTDPDNPCQDCQCKDGTVQCSSIVCPPVLCTIPERTPGQCCAKCPDCRYQDQIFLEGEQFSNPLNQCQECWCRDGHVTCTDRGCTGALCSYPLPGTCCQNNCNGCNYAGKEYPNGADFPHPTDKCRQCHCINGNVQCLAQRCPPLLCAEPFPVPGECCPQCPVPPADCPYSGVTYRHMQRFYDPSDKCRDCICNNGTVTCQRKPCAPTPCLHPLQGDCCRSCDGCLMSGKELANGEQFPQPSDPCSVCVCWEGSVTCQPKTCPVLNCPFPAPGQCCKECQDCQYFGEVYLNGQEFSAPEDSCSRCVCADGFVTCSKKPCYKAGCTHPSTPPGKCCPVCDGCSYNGDALINSQSVPDPSNPLCSECTCRAGSVQCVRKLCGPTSCPHPVTGPCDCPICQGCHFQGHNYIDGEVFTSAQSQCEQCRCMRGHVTCGPRPCDQVTCPHPAEDPCMCPVCDGCNYSGRDCTNGESFPDPEDECSHCTCRNGEVACISVPCPRVSCMYPITPRGECCPRCTGICKHNGRVYQSGDTFHPPGDLCTKCSCQNEMVNCQRVRCSQECSHPVLSPASSCCPVCDRCFYENREYANHETFTSTSDPCQRCVCLDGSVTCTHVVCPYVSCANPITKPGQCCRECPVCRYQGKEFSEGAHWVPHTDPCLKCTCSNGHVDCEPPQCPPLPCTQQVTDPGTCCPRCRGCVYNGREYRDNSNWLSSSDHCMSCMCVDGVTTCSKLQCITSCTNQITIPGECCPVCADCISNSKVYLPGDSYNPSKDPCEICTCESLPNGQQYRHCTKKQCPSLLDCPRSYILPPAEGQCCSSCAQALSNCTNTLVGNEIQATDDPCYTCHCKDLTWVCVHQPCPALSCPRSEQFTHSGSCCPVCNECVVEIEGRRVPDGETWTDRQDPCVTCTCTLGHVECQIEECQPVQCQEGERKVKRPGTCCHECQASAVSCWYQGQRFLSNEHWQVDECTACTCVSGEVHCHSERCPQVSCTAEETPALIPGMCCPHCIPRPATCIAFGDPHYRTFDGKMYHFQGSCTYVLSEDCEGGDFSIHVTNDDRGLRGVSWTKEVTVLIGDAVVQLLQDWVVMVDYQTVELPFLKEPYIYIERKTNTILLNSNIGVKVQWNGRSHLEVSVPGTYRDHLCGLCGNFNNYPQDDLRDRRGQILMSEAAFGNSWRVQSSNDSSSSCWDGQDVDPCKQAGYRARKEANGRCKLLKSSVFEPCHRVVPPEMFFASCVYDLCACGAGDECLCDVLEAYASECREAGVILQWRSPALCAVGCPHDRGYVFDECGPPCPKTCFNKDVPLGVLESHCFKPCVPGCQCPAGLVEHESHCIPPESCPKIIHGNL
The following text describes a protein:
Function:
Transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate. Acts as a master regulator of common NS functions such as Phm expression and neuropeptide production. Plays a role as a regulator of peptide-containing large dense-core vesicle (LDCV) production and peptidergic cell differentiation. Controls transcription of FMRFamide in Tv neuronal cells and Fur1 in Ap-let cells (Tvb and dorsal apterous cells). Also required for up-regulation of Phm in Tv and Ap-let cells, and expression of three neuropeptide genes, Ms, FMRFamide and Lk. Influences both regulated and constitutive secretory activity in neuroendocrine cells at embryonic and postembryonic level. Loss of function studies show reduced cellular levels of various neuropeptides and neuropeptide biosynthetic enzymes.
Subcellular Localization:
Cytoplasm.
Domain:
The basic domain binds to the canonical E-box (5'-CANNTG-3'), with a particular preference for TA relative to AT or CG in the variable central nucleotide positions.
Sequence:
MDATQLTELMGSHDFMQLQHQLHHNNNNYNTDGHNGLSSESAEGSSRPVRRATRRTSQLSNNTYDLEMTDSSSQSDDTSGGGGSSNGGGSTTNTGHPSGCSLGGQGPSGRGRVQQASSGACPSTIAPNSTSSNSSNANGNASRRRKGALNAKERNMRRLESNERERMRMHSLNDAFQSLREVIPHVEMERRLSKIETLTLAKNYIINLTHIILSKRNEEAAALELNSGAVGGVLLSNLSSESGGPVASGIPANSNAATICFEDTLASGGAFDCAILAATDGSLLNAATVTTSPAMQSIQSQAIHLQTPMEQQQQQASHLPHHQQAMHGHGHLGASIQSQQQPSLVLNGTTSVGLGIGIGVGVGVGVGVCNNAPSFADINDNFDEPFREFL
The following text describes a protein:
Function:
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
Subcellular Localization:
Cytoplasm. Dynein axonemal particle.
Sequence:
MTNTKADDGNKVTMTADELKRFQESFKDKEFRTLFFDYMNELSDPKNREIYEHELSMLESEKGNDVRYVKPIGVYVIKTATDTFESPVKVFINMCSSVEIEAAAQSTSKSFSKPGGKHWNIPYSLASPRDDVDNAKKPCQVYDCVFHPDTLKMGSSYPAFSRLLESTAIEGIEKQFNVKLKRDYKQIQMKCKGTPAMTMIRTKRDSPARSNVETSIEFIEKIQKQKKSMAEKNTIDTKQIPVANVQIGPKVPEYTIVHQQLFDDYQKFTSEREKHNGARPDKIVIRISLPGIASASEADLDVDPMTLNLVVSEKYKLHIDLPFPVFNEKGDAKFDKSKSDLVITLPVVPAPCKLADHEDITFVKQEDEPIESLVEDISATNTNPLISVLGSETVASLLPKKTDSDEIENQPMELAAEVSSQLASESNESVQNISSQKDVSALVEQFTDQLKITQSKSQIPPFHITQSAMHTTIVVDVANIAQDSLDIFIEAEETSIGFRDASGVEWKLHLKFESQIDTARIQPFDISDSNGVLVVYKTTSQLWNKITVVHQDGSSTVQILNTIENTYSMDEDPDLVVDAGKQDNAHTVTAHRVNGNVVVDIMPKKDILAALSTTGIEVEQNTVADAKPIAAPTTLHCDSTSTHIPVKLINTCLYDLD
The following text describes a protein:
Function:
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MATNAQLSQKESDIKMMCAAEVHLGTKNCNYQMERYVFKRRNDGIYIFNLGKTWEKLQMAARVIVAIENPQDIIVQSARPYGQRAVLKFAQYTGANAIAGRHTPGTFTNQMQTSFSEPRLLILTDPRTDHQPIKEGALGNIPIIAFCDTDSPMRFVDIGIPANNKGKHSIGCLFWLLARMVLQMRGTIRPAQKWDVMVDLFFYREPEEAKQPEDEEAAPQADFGLPAPEYGAAGGEWTTAQIPDASWTGDAQQPISAAPAAASWNDDSAAPAADGWDTAVPPTSAVPAAGWE
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDGWQEHVDAIRSKGLFVETETTQKYYPIPAMLADESQGEFELVILFTKAMQLDSMLQRIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKIYAGVTLWSSELEGAGHIMATGTGTIELQPIASQDSAQEAKVIATLNSAGLNAEISPDVLLSIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVMNTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNKLLTQLIHAKEAQ