lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). Plays an important role in several nuclear export and import pathways including poly(A)+ RNA, tRNA, pre-ribosome, and protein transport. By binding ATPase AFG2, promotes AFG2-mediated release of shuttling protein RLP24 from pre-60S ribosomal particles.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Biased towards cytoplasmic side.
Domain:
Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: GLFG repeats are especially abundant in NUPs in the central region (lacking a charged environment but are enriched in Ser, Thr, Gln, and Asn).
Sequence:
MFGVSRGAFPSATTQPFGSTGSTFGGQQQQQQPVANTSAFGLSQQTNTTQAPAFGNFGNQTSNSPFGMSGSTTANGTPFGQSQLTNNNASGSIFGGMGNNTALSAGSASVVPNSTAGTSIKPFTTFEEKDPTTGVINVFQSITCMPEYRNFSFEELRFQDYQAGRKFGTSQNGTGTTFNNPQGTTNTGFGIMGNNNSTTSATTGGLFGQKPATGMFGTGTGSGGGFGSGATNSTGLFGSSTNLSGNSAFGANKPATSGGLFGNTTNNPTNGTNNTGLFGQQNSNTNGGLFGQQQNSFGANNVSNGGAFGQVNRGAFPQQQTQQGSGGIFGQSNANANGGAFGQQQGTGALFGAKPASGGLFGQSAGSKAFGMNTNPTGTTGGLFGQTNQQQSGGGLFGQQQNSNAGGLFGQNNQSQNQSGLFGQQNSSNAFGQPQQQGGLFGSKPAGGLFGQQQGASTFASGNAQNNSIFGQNNQQQQSTGGLFGQQNNQSQSQPGGLFGQTNQNNNQPFGQNGLQQPQQNNSLFGAKPTGFGNTSLFSNSTTNQSNGISGNNLQQQSGGLFQNKQQPASGGLFGSKPSNTVGGGLFGNNQVANQNNPASTSGGLFGSKPATGSLFGGTNSTAPNASSGGIFGSNNASNTAATTNSTGLFGNKPVGAGASTSAGGLFGNNNNSSLNNSNGSTGLFGSNNTSQSTNAGGLFQNNTSTNTSGGGLFSQPSQSMAQSQNALQQQQQQQRLQIQNNNPYGTNELFSKATVTNTVSYPIQPSATKIKADERKKASLTNAYKMIPKTLFTAKLKTNNSVMDKAQIKVDPKLSISIDKKNNQIAISNQQEENLDESILKASELLFNPDKRSFKNLINNRKMLIASEEKNNGSQNNDMNFKSKSEEQETILGKPKMDEKETANGGERMVLSSKNDGEDSATKHHSRNMDEENKENVADLQKQEYSEDDKKAVFADVAEKDASFINENYYISPSLDTLSSYSLLQLRKVPHLVVGHKSYGKIEFLEPVDLAGIPLTSLGGVIITFEPKTCIIYANLPNRPKRGEGINVRARITCFNCYPVDKSTRKPIKDPNHQLVKRHIERLKKNPNSKFESYDADSGTYVFIVNHAAEQT
The following text describes a protein:
Function:
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
Subcellular Localization:
Cytoplasm.
Sequence:
MYKTEVYILGQKYTIKGEKSPEYIQRLAAYVDEKLRKVYEQNSAMPPLRAAILACFYIADELYEMKKDCEDTKHQLKKLEEKTNELLLLLD
The following text describes a protein:
Function:
Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates (By similarity). Required during pollen development.
Subcellular Localization:
Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MAYSVVRLRKVSALGISRVLQADKGSLWRFHFEPEFGDLLRLGVLTRNYRKNSGSPKFDFTGTGTTSKFDFTDLTCPHTWYPIARKKKRKVILHVGPTNSGKTYSALKHLEQSSSGVYCGPLRLLAWEVAKRLNKANVPCDLITGQEKDLVEGATHKAVTVEMADVTSVYDCAIIDEIQMVGCKQRGFAFTRALLGIAADELHLCGDPAVVPLVEDILKVTGDDVEVHTYERLSPLVPLKVPVSSVSSIKTGDCLVTFSRKDIYAYKKTIERAGKHLCSVVYGSLPPETRTAQATRFNDETNDFDVLVASDAIGMGLNLNISRIIFSTLQKYDGSETRDLTVSEIKQIAGRAGRFQSKFPIGEVTCLHKEDLPLLHSSLKSPSPILERAGLFPTFDLLSGYSQAHPTHGLYQILEHFVENAKLSSNYFISNVEDMMKVAAIVDELPLGLQEKYLFVVSPVDVNDEISGQGLAQFAQNFSKAGIVRLREILAPDRVKVPKTPTELKELESIHKVLDLYVWLSLRLEDSFPDREVAASQKSICNLLIEQFLEGNRLNSPARFSRYLRRQKLSE
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MESRSPSRKRTDVLPHFDESMTTPPKQPRPSRNATPTRTPKAKMMKQVEAMSVDSDDNIPVVRKRKDEEAENRKPFVNEMPEETVSVSAIENYFLKGKNVQQNKKRRRKQKKDRRGERGNDSQEEEEDDEEKEEEDEGDKRYEECDLNALRKFHEQSHQLEAEVVEKLGKQHFDKWTLYLATGFNILVHGLGSIRPLLHDYAERMGREYTVVEVEGFRPECSPRNVLTTIYDLLHLKFQKRRSLIEFARQMAEAVTDRDVILVIHNMDDPPFRAEGDMEVLAILAASAHYHIVASAQHVNRMLLWNMRSVASFNWKHEHVNTDLPMQAEIFAGASTLLGLCSAESVSTHTISSLEVLWLSLNDNARAIFHAIFSLVYGTEPDAAAKSVSFWDLFNLCKDEFWVSSDAALRQQLVEFCDHRLIRTRRGNDGNEKIYATADRVIIDRFLKSVNKPLVEMQVGEDGEDE
The following text describes a protein:
Function:
Isomerase that catalyzes the interconversion of fructose-6-P and mannose-6-P and has a critical role in the supply of D-mannose derivatives required for many eukaryotic glycosylation reactions.
Subcellular Localization:
Cytoplasm.
Sequence:
MWGAARPLRRRSRNYISHEALGVEGPRVLPGRAYVREGRFGAARMTAQQVFPLSCVVQQYAWGKMGSNSEVARLLASSDPLARISEDKPYAEMWMGTHPRGDAKILDNRISQKTLGQWIAENQDSLGSKVKDIFNGKLPFLFKVLSVETALSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTSFQGLCGFRPVEEIVTFLTKVPEFQFLIGDNAATQLKQSMSRDSQATASALQSCFSHLMKSEKKVVVEQLNLLVKRISQQVAAGNNMEDICGDLLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTSSPSKDRLFLPTRSQEDPYLSIYDPPVPDFTVMKMEVPGSITEYKVLAVDSASILLMVQGTVTASTPTAQSTIPLQRGGVLFIGANESVSLKLTVPEDLLIFRACCLL
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Nucleus.
Sequence:
MTYTSERLKGDIATFMANSGGEQAGMAASGTAAALEKGTVRLVDVVMALRAHMTAEDDRTRMRAMGYLATVLEALGGEGLQRNDIAVMLEFCANKVDDSACAQEALHALEALVGMARFGVGQVEAVLTVLKDQYQPGSYLAATRYRAFRLLEKVLGLFGSALVTNSEQNDLFIETFIAVANGEKDPRNLLLSFRLNMEIGRQLVNVEKFKEDLFDILFCYFPITFKPPKNDPYRITNEDLKQALREAIAGTQLYADDAFGNLVDKLAASSPSVKNDTLLTLQLCIHKFAAEDCAKNWMPIWQALKFEIMNSTESDDPASGVPQFDNYREALETVRLIASKLLHLDMGAFDKFRTHVFDDLKSNFAYEKELKQSCGILSSIASVNRIAFDRVMDKVLPLFFGTQQDLDISKQRLLILNLSFFFDAYIKVFGETGEDVRQVSTDGNKLLGHKDEIIMTLGKALMSSKVEVSLRTLAIIEFTKLIKMQGYLKHEERSMVIQYLTETILTDDNKNIYIACLEGLKVISRNYEADVHEVSLKRILELLPESASAETVIVNGEETSVKHILKVIIDFTSSTHKLVEESIHGLVQKLCKVAPQENSSEYCFLLASSLYCLFVPNGELFTPKDGTAFKESIYPSLMAATLNSTSIYHHDHNLSLLANILSYLNMRSDSAKHHEELEAHQKLFITNKRVLEVPGRSIAVFLNILAGLDKNCKLEDSTGIVKQVVTMLLKSPLELSPFEQLHYQQLLALLANKWCSDKEITEVVNELNLKERSMEILVWLNKGLLMKNSPVATSYLAYFVEQLSRPEGVAVAPYFDILAKDLPIFRRYKGIPFQNNVRLLYKQKLFSDVAVKLVDGFKNTDDLKVKANYLSSLSLILRHTPTDITISYIEELLPLLLQALEFEDGNVRASSLQTLFDTVEHAPQVIAGHVHTLLPRLIQLAQPDRHNKVQVRMLALRTLDALPGHIPLNHLLPFRNDILSGLVPSLGDPKRAVRKQCVDTRQTYYELGHAQA
The following text describes a protein:
Function:
May be involved in protection from oxidative damage.
Subcellular Localization:
Mitochondrion.
Sequence:
MSYHDARRRHPHPIQTFRPESEYSSSAPGSGAQTPTGSGASSSQLPGLVSSIWGGLIRRFSAETPSLTHSQSYPADSSHSHFDDHNYNNSNDNNGVDGVYVPPRFHETIQRTASPMQPPPLEPVQLKGFAPDTPASARILTQAIAEEIRIMVPTRLSIVDEWNLVYSLDQDGASLGTLYDKCAKYSGRRVGFVLVVKDAEGGIFGAYLSDFPHPAPKYFGTGECFLWRASVMASLPPPPSADTTNLRGRTSTISSVGTGTDTATNTATNHNSGDDLASCTVLRATTTATPPHNDSADDLFADLTGTVDQTTIRFKAFPYSGVNDYYILCESHFLSVGAGDGKFGLWLDDGLEKGVSSTSQTFGNEQLSDQGEKFSVLGVEVWVIGSGGL
The following text describes a protein:
Function:
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
Sequence:
MASGSAEHDGAVRETASDASLCKLSASQLGYYADPFVQFFVKSPSRRMPLINRGYYARVAAVESLVRKFLGAGQQRKQVVILGAGLDTMFFRLKSSGMLANCEYVEMDFPDVTMQKVSTIKRRKPLNALLGLEDAKDFMAAVSSGYTELNVPGYHLLPCDLRDLAATTTQLEAAGVDRNLPTLFVSECVLIYMEAKFSTQLVGWAASCFSDVSFALYEQILPDDAFGRVMMSNIKARGCDLLSIYDFPTVEAQIARFTEHSYEVAQCWDMNKIYYHYLDPAERAKRERLEIFDELEEFHLLQAHYCVVVASKLASTPAARALTLGEVNT
The following text describes a protein:
Function:
Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF.
Miscellaneous:
MISCELLANEOUS: Originally the subunits of the type I platelet-activating factor (PAF) acetylhydrolase was named alpha (PAFAH1B1), beta (PAFAH1B2) and gamma (PAFAH1B3) (By similarity). Now these subunits have been renamed beta (PAFAH1B1), alpha2 (PAFAH1B2) and alpha1 (PAFAH1B3) respectively (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSHGDSNPAAVPHAADDIQGDDRWMSQHNRFVSDCKDKEPDVLFVGDSMVQLLQQYEIWRELFSPLHALNFWIGGDTTGHVLWRLKNGELENIKPKVIVVWVGTNNYGNTAEEVAGGIEAIVRLINTQQPQAKVIVLGLLPRGEKPNPLRQKNAKVNHLLKASLPKLPNVQLLDVDAGFVHSDGTISYHDMFDFLHLTGGAYAKICKPLHELIMQLLEETPEEKRAALA
The following text describes a protein:
Function:
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MIRPACRTAKAWRYEVALRPNTVVLCSRIWSRSTSAQAVTHARAASTQLQQRCLGPFSSTRFYTSSTSSQQAVSASSSSPKTATRDVSDLDRLETRTFSIISHVDHGKSTLADRLLELTGTIPSDGSNQQVLDKLKVERERGITVKSQAVTMVYDYDGPREGFISAFQDGFVPRPGRYLLNLIDCPGHVDFSYEVSRSLSACQSALLVVDATQGVQAQSITVFELAKQKNLTIVPVLNKSDLPASDPDRCSLQMEEILGIDTTLPGQEPLLISAKTGRGVDSVLRALVERTKPPTGVEDGKLEGREGPGFRALVFDSWYDQYKGVVSLVSIADGAVKKGDRITSCHTGKRYEVLSLGVNSPEMMATHVLRKGQVGWIIANMKDMSEAQIGDTFHLASEKVEPLEGFAPTVPMVYAGIFPIETTDFTKLEEAIQRLALNDRSVTVQRESSMALGQGCRLGFLGLLHLDVFRQRLEDEYGHAILVTAPSVPYKVTWRDGREEIVSNPIHFPDDSERKSKVTLLEEPMVKGVVRCPEEYTGEIMQLCAEHRGKQLEVSFPATASAIRSVQMTYRLPLSEIVTDFFDKLKSCSSGFASFEYSEDGYGVSDLVKLNFVISNTILDSLSIIMHRSKVMYNARQWTKKLKEIIPRQQFEVSIQATTGSKVIARETLSAYRKDVTAGLYGGHYERKLKHLNKQKEGKKRLKALGVGRVQIPTEKFLEVLDTRTKAK
The following text describes a protein:
Function:
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Required for learming and memory by regulating neuronal Ca(2+), which is essential for the development of synaptic plasticity (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDLQQSTTITSLEKWCLDESLSGCRRHYSVKKKLKLIRVLGLFMGLVAISTVSFSISAFSETDTQSTGEASVVSGPRVAQGYHQRTLLDLNDKILDYTPQPPLSKEGESENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMINRNKVVKVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTSTDVEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSVLLEDRILTCPVSI
The following text describes a protein:
Function:
Involved in terpene biosynthesis in roots. Possesses sesquiterpene (C15) synthase activity in vitro. Does not seem to be involved in diterpene (C20) biosynthesis.
Subcellular Localization:
Cytoplasm.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MEASKCFGPRTLPIIHNVPLCLKTNFSLFPCRLLQSQSLSSKKSTKHYLFRVKAETSGDLESTRPLTYFSPSYWGDHFLSVSIDDSEFEALEKEIETVFKPKVRDMLMSPHSSDKERIRLIHLLISLGIAYYYENEIEEILHKAYGKLACLISDEDDLETIAIMFEVFRLYGHKMPCDVFERFKSEDGKFKESLVGDVRGLLQLYEAAHLGAPSEDIMDEALSFARYHLEPLAGTETSSNLFKHVENVLYRARYHSIEILVARQYISFYDQEEDQDETLLRFSKLNFNFCQMHYVKELKIVTRWWKELGIASKLPYSIRERNVETYLGGLGVLFEPRYSLARIFLAKLTLIMTVVDDTCDAYATLPEVQSLHDAFHRWDLRAMEELPRYMRIIYQSVFETVEDIDREMIARGKHGRLQLTIDEIKSLMIWYLGIAKWARSDQVPSFEDYMEIGTPSSALDDFASYGFIAMDDCDQKQLKEWFYSKPKIFHALNALFRIRNDIVTFEQEMSRGEVANGVNCYMKQHGVTKEAAVEELRKMERESYKIMIEEFMTSKAMPRQILVRPVNIARVMDLFYKEADGFGHPDQKLLQLIASLFLHPIPL
The following text describes a protein:
Function:
Part of the ABC transporter complex PstSACB involved in phosphate import.
Subcellular Localization:
Periplasm.
Sequence:
MKVMRTTVATVVAATLSMSAFSVFAEASLTGAGATFPAPVYAKWADTYQKETGNKVNYQGIGSSGGVKQIIANTVDFGASDAPLSDEKLAQEGLFQFPTVIGGVVLAVNIPGLKSGELVLDGKTLGDIYLGKIKKWDDEAIAKLNPGLKLPSQNIAVVRRADGSGTSFVFTSYLAKVNEEWKNNVGTGSTVKWPIGLGGKGNDGIAAFVQRLPGAIGYVEYAYAKQNNLAYTKLISADGKPVSPTEENFANAAKGADWSKTFAQDLTNQKGEDAWPITSTTFILIHKDQKKPEQGTEVLKFFDWAYKTGAKQANDLDYASLPDSVVEQVRAAWKTNIKDSSGKPLY
The following text describes a protein:
Function:
Pore-forming subunit of inward rectifying Ca(2+) release-activated Ca(2+) (CRAC) channels. Assembles in hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor Stim, a process known as store-operated Ca(2+) entry (SOCE). Regulates transcription factor NFAT nuclear import.
Miscellaneous:
MISCELLANEOUS: In Greek mythology, the 'Orai' are the keepers of the gates of heaven: Eunomia (order or harmony), Dike (justice) and Eirene (peace).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSVWTTANNSGLETPTKSPITSSVPRAARSSAVITTGNHQQHHFQHVVAAAVAAATSVATGHQFQQQFPLHAHPHPQHHSNSPTGSGSNSNNSAGFQRTSISNSLLQFPPPPPPSSQNQAKPRGHHRTASSSMSQSGEDLHSPTYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVPPGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCNLHSISLVHESPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYDLSPPAAWSACVVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQMEQDHLEHHNNIRNNGMNYGASGDIV
The following text describes a protein:
Function:
Part of the ABC transporter complex ThiBPQ involved in thiamine import. Is also involved in thiamine pyrophosphate transport.
Subcellular Localization:
Periplasm.
Sequence:
MLKKYLPLLLLCAAPAFAKPVLTVYTYDSFAADWGPGPAVKKAFEADCNCELKLVALEDGVSLLNRLRMEGKNSKADVVLGLDNNLLEAATQTKLFAKSGVANEAVKVPGGWKNDTFVPFDYGYFAFVYDKSKLKNPPKSLKELVESDQKWRVIYQDPRTSTPGLGLLLWMRKVYGDNAPQAWQKLAAKTVTVTKGWSEAYGLFLKGESDLVLSYTTSPAYHIIEEKKDNYAAANFSEGHYLQVEVAARTVASKQPELAEKFLKFMVSPAFQNAIPTGNWMYPVADVALPAGFESLAKPATTLEFTPQQVAAQRQAWISEWQRAVSR
The following text describes a protein:
Function:
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins such as maltotriose.
Subcellular Localization:
Periplasm.
Sequence:
MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK
The following text describes a protein:
Function:
Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MDDVSAYSHSSVHLAVLRRDHASLRRIVIALPRLPKAGEVTTEAESILAERTADVVASAIDRRDVPNRETPLHLAVRMRDPISAEILMTAGADWSLQNENGWSALQEAVCTREESISMVIAYHYQPLAWAKWCRRLPRIVSSISRIRDFYMEISFHFESSVIPFIGRIAPSDTYRLWKRGSNLRADMTLSGFDGFRIQRSDQTFLFFGDGLSSDSCSVPLGPGSLIVLAHKEKEITNALEGAGLTPTEAEVAREVALMSQTNMYRPGIDVTQAELVPHLNWRRQERTEMVGSLKCKVYDMLHVSVSVKSRRVPGAMTDEELFAVDNDENKLVTNANHDELDDILTAEERLQLNSALGMENSADGFDEYEGNKDLDSNGTSNNSKDKKGGNWFGWNGKKSSKEEYPKPTATMTRKTSNVHQNSDFLKEEDASTTTEKEKKGKEKGKEKGGGGTKKKKCGVANDLNNNSSSNKHESEYKKGLKPVLWLTPDFPLQIEEILPLLDVLANKVKAIRRLRELLTTKMPQGTFPAKIAIPIVPTIRVLVTFTKFEELKSSDEFATPPSSPTHLDHKTKEADSSSSPWYSWIRTGRNGGDRQSNNDGFKEDSDPFQIPSDYTWVDANEKKRRMKAKKAKQKKNVTRKPLSKDAVTAGHQLADGFE
The following text describes a protein:
Function:
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
Sequence:
MFIVVEGGEGAGKTQFIQALSKRLIEEGREIVTTREPGGCSLGDSVRGLLLDPEQKISPYAELLLFLAARAQHIQEKIIPALKSGKTVISDRFHDSTIVYQGIAGGLGESFVTNLCYHVVGDKPFLPDITFLLDIPAREGLLRKARQKHLDKFEQKPQIFHRSVREGFLALAEKAPDRYKVLDALLPTEASVDQALLQIRALI
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MTYAKFNMTQRTARAYYSNCLLVGEAGRGVNRRSRRLKIIKMFESLVTRLFNKDCQSMRLIRKLALPKQKHTKKKKKKKVMFRLLREPVGLPAAAVRFSGHTIVDRSELSCRPARPRAARRPAGLGSLPQISSDRLLGEKSVSRLSRICKGEKIWNHKVENFFLSVWKKPFVMNGIGGVRARGGERRKGGEISRLPLALGLDVNIYYVCLFSPRRWLRSASWNRPWRRGAERGGGWGGSGVSRDPQGCQCPVLRVSGLSKLPPTAQASPSDAESHLLRQRCGCSLRRLFLVPWQQWLRLRRPPPTPISGRHAPGGRLPALSMLAAVPGQRCPTCQEQGAQRQLHEAGSGPRAPARSARLTPAQRRTYQCH
The following text describes a protein:
Function:
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASSLSTTASASMVTKSAAILPHYNTHRLSTQSFRLSQKPKLRFLAKGLQPTRDGTYLVKAQLNEVAVDGSSNAAASTLAKSEVPLQEAKDAKPSNEPSPPSLATEESISEFISQVSSLVKLVDSRDIVELQLKQLDCELLIRKKEALPLPPSHSPVVMMHSHPPPPSPVMPAATPAASAAAPAAASSPSPSAISPSPPSKSVKSSLPPFKCPMAGTFYRSPAPGEPSFVKVGDKVQKGQVVCIIEAMKLMNEIEADQTGTIVEILAEDGKPVSVDTPLFVIEP
The following text describes a protein:
Function:
Catalyzes the ligation of coenzyme A (CoA) to 4-hydroxybutyrate (4HB). It can also use butyrate, valerate, propionate, acetate and 3-hydroxybutyrate (3HB) as substrates.
Sequence:
MGGFKIPNYEGVDPTGSWYSVLTPLLFLERAGKYFKDKTAVVYRDSRYTYSTFYDNVMVQASALMRRGFSREDKLSFISRNRPEFLESFFGVPYAGGVLVPINFRLSPKEMAYIINHSDSKFVVVDEPYLNSLLEVKDQIKAEIILLEDPDNPSASETARKEVRMTYRELVKGGSRDPLPIPAKEEYSMITLYYTSGTTGLPKGVMHHHRGAFLNAMAEVLEHQMDLNSVYLWTLPMFHAASWGFSWATVAVGATNVCLDKVDYPLIYRLVEKERVTHMCAAPTVYVNLADYMKRNNLKFSNRVHMLVAGAAPAPATLKAMQEIGGYMCHVYGLTETYGPHSICEWRREWDSLPLEEQAKLKARQGIPYVSFEMDVFDANGKPVPWDGKTIGEVVMRGHNVALGYYKNPEKTAESFRDGWFHSGDAAVVHPDGYIEIVDRFKDLINTGGEKVSSILVEKTLMEIPGVKAVAVYGTPDEKWGEVVTARIELQEGVKLTEEEVIKFCKERLAHFECPKIVEFGPIPMTATGKMQKYVLRNEAKAKANKEKS
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MELTKIVEALAVLLIIESSRASVHRTDSTAANACQAADDFAAITRAINRQVAELQNKIDEGHRTLLKLTVAAVAQSSRKEPAAALLLAESGSRLQAATMQLSNIKDRAATIANNIAKLGGLQEAVAELLNAKIPAKAPAAVAAGAAFGVDGFAIQLAGVGGKQSICNEHEKQAPRNKEAKVKVKNAYPITFYHATKADKTSGTNGNGPRACVRADTLTTACATSSSDQTNFLITGGPVTKAVQTQYTATQEAATKYTAQAKQTTEQFPPQNTVEALLNGLIELEADLNKLNFQTSSLLPTETINGEETKQALLQILKPGMAREKVSDHEKQIEELKKKLLKSDKTDAGTKLWQEIGKTTSPAVVAQSTKAEEISGIEDLGKLAATLGHYLVQETTKPSSKEQCNFNKEETGCDGKEQDKCNGKCEWKEINGKGECKSKTGEEGVKAENEGKTTTNTTGRNSFAIKKTPLLLAFLLS
The following text describes a protein:
Function:
E2 conjugating enzyme that associates with the E3 ubiquitin-protein ligase EL5 to mediate ubiquitination of target proteins.
Sequence:
MALRRIVKELKDLQRDPPTSCSAGPVSPEDMYQWQATIMGPAESPYAGGVFVASIQFPADYPFKPPKVAFRTKVFHPNINSSGSICLDILKDQWSPALTIAKVLLSVCSLLTDPNPDDPLVPEIAHMCKADRARYEQTARTWTHKYAMG
The following text describes a protein:
Function:
Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
Sequence:
MRMVDLIAKKRDGHALTTEEINFIVEGYTNGDIPDYQVSSLAMAIFFQDMNDQERADLTMAMVNSGDTIDLSAIEGVKVDKHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGTIDKLEAVPGFHVEIENDEFMRLVNENKIAVIGQSGNLTPADKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAKRLAEAMVRIGNNVGRNTMAVISDMSQPLGEAIGNALEVQEAIDTLQGKGPKDLEELCLTLGSQMVYLAGQASSLEDAREKLIEVMNNGKALESFKTFLSAQGGDASVVDDPSKLPQAQFKIEVEAKEDGYVSEIVADEIGTAAMLLGAGRATKESEIDLAVGLMLRKKVGDSVKQGESLVTIYANRENVEDVKAKIYENMKISKEHVDAPTLVHGIVTK
The following text describes a protein:
Function:
Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (By similarity). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (By similarity). Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription (By similarity). Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required in the stress fiber dynamics and cell migration (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Enriched in punctate localization in the cytoplasm.
Domain:
The RanBP2-type zinc fingers, also called NZFs, mediate the interaction with ubiquitin and determine linkage specificity. RanBP2-type zinc fingers 1 and 2 (also named NZF1 and NZF2) specifically recognize and bind 'Lys-29'- and 'Lys-33'-linked ubiquitin. RanBP2-type zinc finger 3 (also named NZF3) binds 'Lys-33'-linked ubiquitin and shows weak binding to 'Lys-6'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin chains but it does not interact with 'Lys-29'-linked chains; The OTU domain mediates the deubiquitinating activity; The second ankyrin repeat ANK 2 is termed AnkUBD, it interacts with ubiquitin hydrophobic patch and contributes to linkage specificity.
Sequence:
MSERGIKWACEYCTYENWPSAIKCTMCRAQRPSGTIITEDPFKSGSSDVGRDWDPSSTEGGSSPLICPDSSARPRVKSSYSMENANKWSCHMCTYLNWPRAIRCTQCLSQRRTRSPTESPQSSGSGSRPVAFSVDPCEEYNDRNKLNTRTQHWTCSICTYENWAKAKKCVVCDHPRPNNIEAIEFAETEEASSIINEQDRARWRGSCSSGNSQRRSPPTMKRDSEVKMDFQRIELAGAVGSKEELEVDFKKLKQIKNRMKKTDWLFLNACVGVVEGDLAAIEAYKSSGGDIARQLTADEVRLLNRPSAFDVGYTLVHLAIRFQRQDMLAILLTEVSQQAAKCIPAMVCPELTEQIRREIAASLHQRKGDFACYFLTDLVTFTLPADIEDLPPTVQEKLFDEVLDRDVQKELEEESPIINWSLELATRLDSRLYALWNRTAGDCLLDSVLQATWGIYDKDSVLRKALHDSLHDCSHWFYTRWKDWESWYSQSFGLHFSLREEQWQEDWAFILSLASQPGASLEQTHIFVLAHILRRPIIVYGVKYYKSFRGETLGYTRFQGVYLPLLWEQSFCWKSPIALGYTRGHFSALVAMENDGYGNRGAGANLNTDDDVTITFLPLVDSERKLLHVHFLSAQELGNEEQQEKLLREWLDCCVTEGGVLVAMQKSSRRRNHPLVTQMVEKWLDRYRQIRPCTSLSDGEEDEDDEDE
The following text describes a protein:
Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).
Sequence:
MSYNCCSRNFSSCSHGGYLHYPGSSCGSSYPSNLVYSTDLCSPSTCQLGSSLYRGCQETCWRPNSCQTLCVESSPCHTSCYYPRTHMLCNSCLTMHVGSRGFGSNSCCSLSCGSRSCSSLGCGSNGFRYLNYRIHTSPSQSYRSRFCHPIYFPPRRWFHSSCYQPFCRSGFY