lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a critical role in regulating mitochondrial ultrastructure and function by maintaining the integrity of mitochondrial morphology, particularly the organization of cristae (By similarity). Preferentially binds to negatively charged phospholipids like cardiolipin and phosphatidylinositol 4,5-bisphosphate enhancing its interaction with mitochondrial membranes (By similarity). Induces membrane curvature and tubulation, which are critical for maintaining mitochondrial ultrastructure and the organization of cristae (By similarity). Plays a crucial role in ciliogenesis (By similarity). May play a role in limb development through its role in ciliogenesis (By similarity). Plays a key role in the correct positioning of the annulus, a septin-based ring structure in the sperm flagellum, serving both as a physical barrier and a membrane diffusion barrier that separates the midpiece (MP) from the principal piece (PP) (By similarity). This positioning is essential for proper sperm motility and function (By similarity). Interacts with CBY3 to form a complex which localizes to the curved membrane region of the flagellar pocket (By similarity). By doing so, may provide stability and rigidity to the periannular membrane to prevent membrane deformation (By similarity). This function is crucial for halting annulus migration at the proximal end of the fibrous sheath-containing PP (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Nucleus. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Cell projection, cilium, flagellum. Note=Weak punctate vesicular distribution throughout the cytoplasm. Localizes at the distal end of mother centrioles. Extensive colocalization with CBY1 at mother centrioles. Localizes to the annulus at the junction between the midpiece (MP) and principal piece (PP) of the sperm flagellum.
Domain:
The BAR-like domain displays limited similarity to other BAR domains.
Sequence:
MLRRSLENRDAQTRQLQDAVTNVEKHFGELCQIFAAYVRKTARLRDKADLLVNEINVYASTETPHLKQGLKNFADEFAKLQDYRQAEVERLEAKVVEPLKAYGTIVKMKRDDLKATLTARNREAKQLTQLERTRQRNPSDRHVISQAETELQRATMDATRTTRHLEETIDNFEKQKIKDIKTIFSEFITIEMLFHGKALEVYTAAYQNIQKIDEEEDLEVFRHSLYPQDYSSRLDIVRANSKSPLQRSLSAKCVSGTGQVLTCRLRKDHQTEDDDEEDEDLDVTEEEN
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MTTMAARRSEAAPAPQQLRGSQLKQLRELFRRFDMNGDGSLTQLELAALLRSLGLRPTGDEVHALLAGMDANGNGSVEFDELAAAIAPVLTTQTHLVDQAQLLEVFRAFDRDGNGFISAAELARSMARLGQPLTFEELTRMMRDADTDGDGVISFKEFAAVMAKSALDFLGVA
The following text describes a protein:
Function:
Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap. Has weak activity with L-Ala-gamma-D-Glu-L-Lys, MurNAc-tripeptide and gamma-D-Glu-meso-Dap. Cannot hydrolyze murein tetrapeptide.
Subcellular Localization:
Cytoplasm.
Sequence:
MNRYYSNNQEITVSLIPRTERAAFLITPTSYGKSVLGAPLLYFPAQVESNSRGLILAGTHGDETASIAGLSCALRSLPAECLKHDVILSMNPDANQLGTRANANQVDLNRAFPTQNWTEHGTVYRWSSHTPVRDVKVKTGDKEQLEPEVDALISLIELRRPKFVVSFHEPLAFVDDPAHSDLAKWLGKQFNLPIVDDVDYETPGSFGTWCNERQLPCITVELPPISADLTIEKHLDAFIALLQHDPDL
The following text describes a protein:
Function:
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Subcellular Localization:
Secreted.
Sequence:
MERMIIFCMLFFCFSMVLTATSPKAMKYKQLSKTIDHLKDVVKDKDVELLHTPENPGDGCLLTAVTCFQNGILKLQPRNSQVNATFAKTVKILRRPFLPVSEEHCESSCESYERKKPQEFLNSFSKLMQKLFKNSTAERYGKSTI
The following text describes a protein:
Function:
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).
Sequence:
MDDSSGVQMARALKQAALCLMLLPRFLLAAVMLWLLDFLCIRRKLLLKMGERQDSPDDPPLCVSDSNKMFTLESLRAVWHGQKLDILKTAHLGQTAPNTEVVLVQERRQVRILDCMKGNRPLILNFGSYIADFLVVYIEEAHPSDGWVSSDAPHQIPKHRCLEDRLRAAALMLTEVPGSKVVVDNMDNSSNAAYGAYFERLYVVRDETVVYQGGRGPEEYRISELKTWLQQYRKDGSSHLRPRRSSTAGH
The following text describes a protein:
Function:
The promoter for a critical alginate biosynthetic gene, AlgD, encoding GDP-mannose dehydrogenase, is activated only under conditions reminiscent of the cystic fibrosis lung (i.e. under high osmolarity), and at least two regulatory genes, AlgP and AlgQ, have been implicated in this activation process.
Domain:
The C-terminal domain binds to DNA. It is unknown whether binding is specific or non-specific.
Sequence:
MSANKKPVTTPLHLLQQLSHSLVEHLEGACKQALVDSEKLLAKLEKQRGKAQEKLHKARTKLQDAAKAGKTKAQAKARETISDLEEALDTLKARQADTRTYIVGLKRDVQESLKLAQGVGKVKEAAGKALESRKAKPATKPAAKAAAKPAVKTVAAKPAAKPAAKPAAKPAAKPAAKTAAAKPAAKPTAKPAAKPAAKPAAKTAAAKPAAKPAAKPVAKPAAKPAAKTAAAKPAAKPAAKPVAKPTAKPAAKTAAAKPAAKPAAKPAAKPAAKPVAKSAAAKPAAKPAAKPAAKPAAKPAAKPVAAKPAATKPATAPAAKPAATPSAPAAASSAASATPAAGSNGAAPTSAS
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and cell cycle control. As a component of the NTC complex (or PRP19-associated complex), associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. The cell cycle arrest of SYF2 defective cells may be due to the inefficient splicing of TUB1.
Miscellaneous:
MISCELLANEOUS: Present with 1670 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDFYKLDEKLKELKRKRVDVSIKSRKLADREIQEVSANRKPRVYSMEDVNDADESVGDTESPEKEKAFHYTVQEYDAWERRHPQGKTGQSQRGGISYDQLAKLSYEKTLRNLATQTQNSSKQDSSADEEDNKNVPKKGRIGKVQKDTKTGKITIADDDKLVNKLAVSLQSESKKRYEARKRQMQNAKTLYGVESFINDKNKQFNEKLSRESKGSE
The following text describes a protein:
Function:
Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (By similarity). Involved in the silencing of embryonic stem cell self-renewal. Plays also a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (By similarity).
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Note=Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies.
Sequence:
METCGSPSPLPREPAGGVAMEDRARPLRALPRGQSPPPPLQTSSDAEVMDVGSGGDGQAEPPAEDPLNFYGASLLSKGSSSKARLLVDPNCSGHSPRTARHAPAVRKFSPDLKLLKDVKISVSFTESCRSEDRKVLYTGAERDVRAECGLALSPVIGDVHAGPFGGSVGNGVGAGGESAGKRDEEHELDQEKRVEYAVLDELEDFTDNLELDEEGAGGFTAKAIVQRDRVDEEALNFSYEDDFDNDVDALLEEGLCAPKKRRMEEKYGGDSDHPSDGETSVQPMMTKIKTVLKSRGRPPTEPLPDGWIMTFHNSGVPVYLHRESRVVTWSRPYFLGTGSIRKHGPPLTSIPCLHYRKMKDSEERERAAGIAPPEPELPPDEPDPLGTDAGPPDEKDPLGAEAAPGALGQVKAKVEVCKDESVDLEEFRNYLEKRFDFEQVTVKKFRTWAERRQFNREMKRKQAESERPILPANQKLITLSVQDAPTKKEFVINPNGKSEVCILHEYMQRVLKVRPVYSFFECENPSEPFGASVTIDGVTYGSGTASSKKLAKNKAARATLEILIPDFVKQTSEEKPRDSEELEYFNHISIEDSRVYELTSKAGLLSPYQILHECLKRNHGMGDTSIKFEVVPGKNQKSEYVMACGKHTVRGWCKNKRVGKQLASQKILQLLHPHVKNWGSLLRMYGRESSKMVKQETSDKSVIELQQFARKNKPNLHILSKLQEEMRRLAEEREETRKKPKMSIVASAQPGGEPLCTVDV
The following text describes a protein:
Function:
Appears to contribute to D.radiodurans capacity to survive exposure to ionizing radiation. May play a role in DNA repair and genome reconstitution.
Sequence:
MDTLKKAGTMLAHLDLFHSMLDLRRLLQLAAYMKERGDRAMLISAGEITLIGSESMTAPEVVTSKGETIDAATAYRVLGQLEGYEAPEYAVNREALAALNARAVAELEGSEALRAFGDTLARISAAPTDPAGPERPGTDRAERTAAERTASERATHDRASTERPARPRRSAEPEAVRTEDAPQPNAEASEAGENTPAA
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEEAAPCSEPAKTIKRIDRESVHRICSGQVVLSLGTAVKELVENSLDAGATNIDVRLKDHGAELIEVSDNGGGVEEENFEGLTLKHYTSKIQDFSDLIHVETFGFRGEALSSLCALSDVTISTCHKSAKVGTRLVFDHNGKITQKAPYPRQQGTTVSIQQLFHTLPVRHKEFQRNIKKEYAKMVQILQAYCIISKGVRINCTNQVGQGKKSPVVSTTGGPNLKENIGAVFGKKQLQSLIPFVQLPPNEAVCEEYGLKSTDLPEKLYSITGFISRCDHGVGRSTTDRQFFFINQRPCDPAKVVKLVNEVYHLYNKHQYPFIVLNICVDSECVDINVTPDKRQILLQEEKLLLAILKTSLIEMFGSDVNKLNVNQNLLDIVGNVKAPPGDAEKPWVEMSHHSETENPSSEGKRVMTLSRLRESFSLHQTESYFQSPKKVKQRHSSSKQLSLDTILSTVRTQKAVLSEDSESCHEMKSKMPVPRKYLRKVDDIDSGFCSTSESDAGYNTPEAGSCVISESVNNPIEEEFCSSEEQHQNEYLKTVGHSEKSLECDIQVLGTEHKLNRVNDCNNQTNLPQEATNSLPRVRRFKNEADDFKAGIHPKVENTRNYMPCVDVLVEVKKKTVPLEFSMKALAERVRKIVQQQQKCTETQNYRRFRAKISPGENKVAEDELRKEISKEMFAKMEIIGQFNLGFIIAKLNSDLFIIDQHATDEKYNFEMLQQHTVLQGQKLIAPQNLNLTAVNETVLIENLEIFRKNGFDFVINENAPVTQRVKLISLPTSKNWTFGPQDIDELIFMLSDCPGVMCRPSRVRQMFASRACRKSVMIGTALNVQEMKKLVTHMGEIEHPWNCPHGRPTMRHIASLDLIASE
The following text describes a protein:
Function:
Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAVFDLDLETEEGSEGEGEPEFSPADACPLAESRAAGLEPVGHYEEVELTETSVNPGPERIGPHCFELLRVLGKGNYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTRLEREGIFLEDTACFYLSEITLALGHLHSQGIIYRDLKPENVMLSSQGHIKLTDFGLCKESIHEGTVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLVLPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQKHPFFRHINWEDLLARRVDPPFRPCLQSEEDVSQFDTHFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRTPVSRAAYWAPDLTA
The following text describes a protein:
Function:
Antitoxin component of a type IV toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV). It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles. The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes. The intergenic region was not found to be necessary in another study. Also counteracts the morphological defects caused by overexpression of SulA and DicB on cell shape. Also counteracts the effect of non-cognate toxins YfkI and YpjF.
Miscellaneous:
MISCELLANEOUS: Encoded in prophage CP4-44.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN
The following text describes a protein:
Function:
Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.
Sequence:
MDQYDYGDQEDYEDYDYQDEEFSNYQGSNLKILMVAEKNSIAEAVAYAIGNKVRAKKGRQAFYYFSGMFKGQQANFTVTATNGHLFSRDFPKEYENWNSCDPIDLFQAKTIKKPANKAGIGLLRKCSSGIDYLILWLDNDREGENICFEVDEVKSKVINLGNLIRKLRAKFSSITQTDLKYAYNQLNTGPNILESESVDARQIIDLKVGVAFSRFQTLHFQKKYSMDQMVTFGPCQTPTLGFCVERHEEIVNFVPRAFYTIKLSILNNVGYKQEVEWLGQQIWKEPEAKQVVQQLQKFKQGDVISQQVEQKSKPRPEGINTVSLLKFASSYLGLGPQQAMHVAERLYLNGYISYPRTETTAYPHEFPTPKIINNLQKYKDPLISEHSKYLKTNGHSNPKQGVDVGDHPPITPTENVPQNNLYGEEKTMYEYVVKMFLAAHSKDCKYENHTLKFFVGDHQFKFQSKYILDPGFTKVATWLAITENKSDLTKFVTNNKVQIGFVEYQQGQTSPPDHLTETELITLMDKFKIGTDASMATHINNICERQYVKVEGSSRKLKPTDLGLSLVRGYKRIDPDLVAPQLRSSIESQVDQIAKGKLKCQQVIQDVIQIFTKKYIHFRERINDFQLVQYHQQGINRQIKQSDEEIILSRCGDCNRYLVQSNNSAICKQCIKTYPLLPDCKFKAYGAYRCPFDKFELLFCTSNKSPFNTTLLCPKCFSSSPLVTSEQCTCNICPNVDCEKSKESRMVGKCKSCKIGELILEPFISKGQQICLSCNECWCLYQLVPAVVQVDITKNACTECQLKTFNLITKTKDKEEVKYNNVCLMCYEELNKKLLYAPYLGEKKFMIQQKKQEQPVKQDDVNKETFSKGRKKFSKNPRKNDRHDDDQFTQKKNDNSDWATLLLSQSVTNNKQKPQNKQHQDEPQQQQQQQQQVNEPGLVLLETKKKRNN
The following text describes a protein:
Function:
Regulation of fluid secretion. Stimulates Malpighian tubules fluid secretion by activating the apical membrane V-ATPase via cyclic AMP of principal cells in the main secretory segment.
Subcellular Localization:
Secreted.
Sequence:
MTNRCACFALAFLLFCLLAISSIEAAPMPSQSNGGYGGAGYNELEEVPDDLLMELMTRFGRTIIRARNDLENSKRTVDFGLARGYSGTQEAKHRMGLAAANFAGGPGRRRRSETDV
The following text describes a protein:
Function:
Oxidative deamination of D-amino acids.
Sequence:
MAQRVCIIGAGVVGLATAYALVREGFDVTLVEARERGGLETSYANGGQLSYRYVAPLADSGVPAQALGWLLRNDAPLRLRPRLDPAQWRWLLGFLAACRGSLNRRNAAHLLRLALLSQRTLQDWREEDGLDGFDWRRNGKLVAFRQPASFARARQGLADPSAQFVLTAAECLALEPALSAAPFVGGIHTPDEEVADCHAFCVQLAERLQASGHCRQLHGRRVTKIVEGGAAVRGVEVGGDLIEADHVVLAAGYRSAELMLPGLRLPLYPLKGYSLTLPVGAQHRAPDTSITDYDRKIVYARIGERLRIAAMVDIVGFDPGLEPARLALLRQQARDTFPQGGDFDAAVEWAGMRPATPTGVPLVGNGGYRNLWLNLGHGALGFTLACGSGRLLAEQIGRRPPSIDTTGLLPRGALAG
The following text describes a protein:
Function:
Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
Purified ATP synthase is 25.9 nm long. The hydrophilic A1 domain is 9.4 X 11.5 nm, the central stalk is 8.0 X 3.9 nm and the membrane-bound A0 domain is 6.4 X 10.6 nm; the domains are connected by two stalks. ATP is synthesized or hydrolyzed by the A1 domain while ion translocation occurs via the A0 domain.
Sequence:
MQRVNPTRMELLKLKNKIKLAEKGHKLLKQKRDALIMEFFQIIEQASDLRDKVEAKLAEAYKDLIMAQTVMGTLAVKEAALAAKNDKLEVDMDTKNIMGVTVPTFEIYNVRRKVGERGYSPYGVSSKLDEAAKKFEEALELITELAEIETSIKLLAEEIITTKRRVNALEYVIIPRLKSLKKYISMRLDEMERENFFRLKLIKSRIEKREAEGETV
The following text describes a protein:
Function:
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Is very specific for its substrate, since it is not able to use D-glucose, D-fructose, D-mannose, 2-deoxy-D-glucose, and D-glucosamine as substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKITVKSPGRVNLIGEHTDYTYGYVMPMAIDLYTIITAEKYDKVQLYSEHFNEEKTFTLDNLTKEGSWIDYVKGVLWVLIQEGYKIGGLKGKITGDLPLGAGLSSSASFEVGILEVLNQLYNLNIDPLKKALLAKKAENEFVGVPCGILDQFAVVFGKKDNVIFLDTQTLQYEYIPFPKDVSVLVFYTGVKRELASSEYAERKRIAEESLRILGKESSKEVTEKDLGKLPPLHRKFFSYIVRENARVLEVRDALKEGDIEKVGKILTTAHWDLAENYRVSCEELDFFVKKAMELGAYGARLTGAGFGGSAIALVDKDKAKTIGDAILREYLAKFSWKAKYFVVKPSDGVGV
The following text describes a protein:
Function:
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MPTKKSSSVRMEEVLEEAINTTGGPKGASTIAIKKYIAAHYPHLDIENRTYLLKQAVKRGVSKGQLKQMSGTGFTGFYKLVGGKKEPSLTKRQKDAAKTAAKKVVSKHRAVVKKVSKPPPAFYRDPDEKPTTIDLLEEAIAMVGGPKGASAQAIKKYLAENYPDTKKHLVKQALVRAQKKDLVKQLSGTGASGTFKWIGPKRKPKEREEAPRSPKKTVAAKKMAVPDPPKMEIIIRDAMVEYCEPKEASPQAIKKYLSEHYPHLEIETRSYLLKRALQKGVENGQLIQLSGKGMSGTFRLVESYKPKKPMETMIGVAIKAANEPKEASVGMIKKYIQEHYPTLDIENHMFKLKYKLVSSLLFSQVGMIKKYIREHYPTLDIENHMFKLKRGLEKGVKNGELEQITGKGASGTYQLTEPFIPSPEDLELIEYVPPMEVLLRSAFHRGSKAQVQKPKVAEVKVKKARGRPKGRPVKKPKPKAAGRGRGKGKKGRGRPKKVDKTEPKETEDEPKESASSEEETAKESASEEEPKESASSEEDAQ
The following text describes a protein:
Function:
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
Sequence:
MGVRKLKPVTNGTRHAVLYDFEEIEKLVRKGKEWVLLKKNQVEPEKSLLKWWHRAKGRSRQRGNITARHRGGGHKKLYRIIDFKRDKSLVPAKVVSIEYDPFRSARICLLHYADGEKRYIIWPEGLKVGDTVMSISWEDAEAGKPLPEIKPGNAMPLKYIPEGTIVHNIEFIPGKGGQIARAAGTWAQVLGRSTRKGYVLVRMPSGEVRMIHERCMATVGRVGLAEHELVKLGKAGRARWLGWRPHTRGTAMNPVDHPHGGGEGRTRGKHPESPWGWKTKGYKTRRGKKYSDQFIVTRRDGRPL
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion. Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi. Together with RAB2B, redundantly required for efficient autophagic flux.
Subcellular Localization:
Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity).
Sequence:
SCLLLQFTDKRFQPVHDLTIGVEFGARGAAGALLVYDITRRTASNVEEAFINTAKEIYEK
The following text describes a protein:
Function:
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Sequence:
MTPPPPGRAAPSAPRARVPGPPARSVLLLRLLLLLWAAAASAQGHSRSGPRIFAVWKGHVGQDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRTVNIGSTKGSCLDKRDCENYITLLERRSEGLLACGTNARHPSCWNLVNDTVVPLGEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDKVFRTSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVVVHRMQASHGETYHVLYLTTDRGTIHKVVEPGEQEHSFIFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRCVSIYSSQRSVLQSINPVEPHKECPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALAASLWLGVLPTLTLGLLVH
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. Can bind to DNA (in vitro).
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones; MISCELLANEOUS: Present with 2160 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MGGQESISNNNSDSFIMSSPNLDSQESSISPIDEKKGTDMQTKSLSSYSKGTLLSKQVQNLLEEANKYDPIYGSSLPRGFLRDRNTKGKDNGLVPLVEKVIPPIHKKTNNRNTRKKSSTTTKKDVKKPKAAKVKGKNGRTNHKHTPISKQEIDTAREKKPLKKGRANKKNDRDSPSSTFVDWNGPCLRLQYPLFDIEYLRSHEIYSGTPIQSISLRTNSPQPTSLTSDNDTSSVTTAKLQSILFSNYMEEYKVDFKRSTAIYNPMSEIGKLIEYSCLVFLPSPYAEQLKETILPDLNASFDNSDTKGFVNAINLYNKMIREIPRQRIIDHLETIDKIPRSFIHDFLHIVYTRSIHPQANKLKHYKAFSNYVYGELLPNFLSDVYQQCQLKKGDTFMDLGSGVGNCVVQAALECGCALSFGCEIMDDASDLTILQYEELKKRCKLYGMRLNNVEFSLKKSFVDNNRVAELIPQCDVILVNNFLFDEDLNKKVEKILQTAKVGCKIISLKSLRSLTYQINFYNVENIFNRLKVQRYDLKEDSVSWTHSGGEYYISTVMEDVDESLFSPAARGRRNRGTPVKYTR
The following text describes a protein:
Function:
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
TMTSAEAGDPTLKKPDPLPRSVTLFVNDVGSPMRFYLRPGPAKSRFAALIEAGGGMMCGVQEPGAILLADPKELNGKAAAGYVSTHYILDCVGKNEQLEMHDYKLGQDHAASAPSVSKKKRSTSGRMGYTNSEDAAILQYLSRHKGEVKGNRIWQAMAREGITSHSWQSMKDRYPAAAGNDVAPEMGNEKEEQCQVTSAEEEETSEEESVQRLKQVNRQELKRKRGSRETAQAVKTSTPKQTKTNILKQAIREFESDDETPELMITNVPQNEPRSPESGPPLQNQEQDIQTREEAVQEAIKAVHFLMEECNLSFVKAMQILLKNSGDFQASLHYLRTGHRPDQLPLWTHEDDCVLLSGESSSQDALIEKYGEDGLAKRIAFLLG