lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation. Is required for efficient abscission during cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle. Midbody. Nucleus envelope.
Sequence:
MFSSGPKYQKLTTYLRLAINRLKLLEKKKSELAVKARREIADYITNGKEDRARIRVEHIIREDYLVEAMEIVEMYCDLLIARMGVLQTSKSMDEGLEEPIASILWSTPRLQSDVSELSVISDQLALKYGKEYVASCRKNSLNNVNEKLIHKLNIHAPPKVLVEKYMEEIARLSIFSFLLC
The following text describes a protein:
Function:
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
Composed of a large N-terminal cytoplasmic domain (CD) followed by a juxtamembrane domain (JD) and a transmembrane domain (TMD).
Sequence:
MASFLHIGDIVSLFAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMNRYSAQKQYWKAKQTKQDKDKIADVVLLQKLQHAAQMEQKQNETENKKVHGDVVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKVILNPVNAGQPLHASNYELSDNAGCKEVNSVNGNTSWKINLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKSKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATGNYLAAEMGGPGRASRRNVGEKIKYRLVAVPHGNDIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPAKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVDKLNAGFISQNDRRFVIQLLEDLVFFVSDVPNNGQNVLDVAVPKPNRERQKLMREQNILKQIFGILKAPFKDKGGEGPLVRLEELSDQKNAPYQYMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIKTELRPVKEMSQAHEYLSIEYSEEEVWLTWTDRNNEQHEKSVRQLAQEARAGNAHDENVLSYYRYQLKLFARMCLDRQYLAIHEISKQLGVELIFLCLADEVLPFDLRASFCHLMLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNDSRDDKKNKFASTMEFVEDYLTGVVSEPAPFANQEKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQNPQALLQAEYNDDNGGKDVRRSIQGVGQMVSTMVLSRKPSLFGGTGLSVAGSPESLERGCSIDSENIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFDSSTAAMNLERIGEQAEAMFGIGRTSSMLEVDDEGGRMFLRVLIHLTMHDYAPLVSGALQLLFKHFSQRQEVMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKSSHKGDEVGEGAKKEKKERPNEEALPPTGERSSENYQIVKGILERLNKLCGVGEQMRKKQQRLLKNMDAHKVMLDLLQVPYEKGDAKMQEILRSTHQFLQKFCAGNPGNQALLHKHLSLFLTPGLLEAETMQHIFLNNYQLCAEIGEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDAIMTELTNAGDDVVVFYNDKASLAHMLEMMAAARDGVEENSPLMYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKIAYVNFVNHCYVDTEVEMKEIYTSNHIWTLFENFTLDMARVCKKREKRIADPTLEKYVLTVVLDTITAFFSSPFSENSTSLQTHQTIVVQLLQSTMRLLECPWLQQQHKGSVETCIRTLAMVAKSRAIALPMDLDSHVSSLLNSSASCAVQRNAASYKTATRTFPRVSTPANQWDYKNIIEKLQDIINTLEERLQPLVEAELSVLVDVLHRPELLFLEGTDAYQRCESGGFLSKLIQHSKDLMESEEKLCIKVLRTLQQMLVKKSQYGDRGNTLRKMLLNNYLQNRKSSSKGEIPDPSGSGQDQDWALVAATQCRLDKEGATKLVSDLIMSTKNEKIFQESIGLAIRLLDGGNTEIQKSFYNLMMSDKKSERFFKVLHERMKRAQQETKSTVSVNMSDLGSQPREGRDPGDPGEQAHKGRVPHFPLPSSLSRYSLSLSFRKGHEAGQRGQSHEMGMSVLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEDNVALILQTLETLTEYCQGPCHENQSCIVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDGENAERILISLRPQELVDVIKKAYLQEEECENSEVSPREVGHNIYILALQLSRHNKTLQHLLKPVKRIQEEEEEGISSMLSLNNKQLSQMLKSTAPAQEEEDDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICEFLTEETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGSISFNLAVFINIIIAFFYPYVEGASTGVLGSPLISLLFWILICFSVAALFTKRYSIRPLIVALILRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGIFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVDRLPDNKSKASPLGMPHGSAAFGDTCGADRVGCSSGISVPEAQEEEDEGGTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKFEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIRSLQDKLNSTMKLVSHLTSQLNELKEQMTEQRKRRQRMGFVDVQNCMSR
The following text describes a protein:
Function:
Essential protein required during embryogenesis and pollen development. Endonuclease cleaving pre-rRNA at the 3' end of the mature 18S rRNA (D-site); cleaves 20S pre-rRNA in the cytoplasm. Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.
Subcellular Localization:
Nucleus. Nucleus, nucleoplasm. Cytoplasm.
Sequence:
MDPKPTSMWSSIVKKDPPSKPPVNDGAPAAILGMVGNCKSTKGISIAVVDANAIIEGRQSLTNFADKFVTVPEVLSEIRDPASRRRLAFIPFTIDTMEPSPESLSKVIKFARATGDLQSLSDVDLKLIALSYTLEAQVYGTKNLRDVPPPIQTVRVKRLPEKDLPGWGSNVANLEEWEALENETEEKSNANSKILPLKDLNMNIIASDNVSEVGSVVSHTENHEEDVQEGGKKHRRYPPKKTEIKLEGKMVVEGVDASQGQYDDDDDASDWRPAVSRSTHSKYLRRKARWEHYNALAEQEIQKDQEADKARHTKEANETHAKDSGKNGEDISSILKDMRLEEESLRALQEETEETNAEATLINGEDDIDHDIEVEAEGIDVANQALENLEIASEAEDTFEASSIGDDGSSEQSWSLRALSESSVACITGDYAMQNVILQMGLRLLAPGGMQIRQLHRWILKCHACYTVTPEIGRIFCPKCGNGGTLRKVAVTIGANGAIIAACKPRITLRGTQYSIPMPKGGREAITKNLILREDQLPQKLLHPRTKKKASKPGDEYFVSDDVFLNHHSDRKAPLQPPVRKAMSVFSQKRNPNDNHYSRSMH
The following text describes a protein:
Function:
Required for maturation of 30S ribosomal subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MQKDDVAGRITAVAEQVLTPQGLELVEVEYKREGRQMVLRLFVDKPGGISLDDCAAVSRELSEILDVEDFIRENYTLEVSSPGLNRPLKKEADYERYAGRLVKVRTFELLADEEGNRRKTFLGDLVGLSDGVVTLTLREGQLARIPLDKIAKANLEFEF
The following text describes a protein:
Function:
Secreted ribonuclease that can either promote or restrict cell proliferation of target cells, depending on the context. Endocytosed in target cells via its receptor PLXNB2 and translocates to the cytoplasm or nucleus. Under stress conditions, localizes to the cytoplasm and promotes the assembly of stress granules (SGs): specifically cleaves a subset of tRNAs within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs), resulting in translation repression and inhibition of cell proliferation (By similarity). tiRNas also prevent formation of apoptosome, thereby promoting cell survival (By similarity). Preferentially cleaves RNAs between a pyrimidine and an adenosine residue, suggesting that it cleaves the anticodon loop of tRNA(Ala) (32-UUAGCAU-38) after positions 33 and 36. Cleaves a subset of tRNAs, including tRNA(Ala), tRNA(Glu), tRNA(Gly), tRNA(Lys), tRNA(Val), tRNA(His), tRNA(Asp) and tRNA(Sec). Under growth conditions and in differentiated cells, translocates to the nucleus and stimulates ribosomal RNA (rRNA) transcription, including that containing the initiation site sequences of 45S rRNA, thereby promoting cell growth and proliferation. Angiogenin induces vascularization of normal and malignant tissues via its ability to promote rRNA transcription. Involved in hematopoietic stem and progenitor cell (HSPC) growth and survival by promoting rRNA transcription in growth conditions and inhibiting translation in response to stress, respectively. Mediates the crosstalk between myeloid and intestinal epithelial cells to protect the intestinal epithelial barrier integrity: secreted by myeloid cells and promotes intestinal epithelial cells proliferation and survival (By similarity). Also mediates osteoclast-endothelial cell crosstalk in growing bone: produced by osteoclasts and protects the neighboring vascular cells against senescence by promoting rRNA transcription (By similarity).
Subcellular Localization:
Secreted. Nucleus. Nucleus, nucleolus. Cytoplasm, Stress granule. Note=The secreted protein is rapidly endocytosed by target cells following interaction with PLXNB2 receptor and translocated to the cytoplasm and nucleus. In the nucleus, accumulates in the nucleolus and binds to DNA.
Sequence:
MVMGLGVLLLVFMLGLGLTPPTLAQDNSRYTDFLAQHYDPKPQGRDDRYCESIMRRRGLTSPCKGINTFIHGSKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCHYRATADFRNIVVACENGLPVHLDQSIFRRL
The following text describes a protein:
Function:
Antifibrinolytic and antimicrobial serine protease inhibitor. Inhibits trypsin, plasmin and microbial serine proteases but not chymotrypsin, thrombin and elastase. Inhibits the plasmin-mediated degradation of fibrin to fibrin degradation products. Also binds to bacterial and fungal surfaces and exhibits antimicrobial activity against fungi as well as Gram-positive and Gram-negative bacteria.
Subcellular Localization:
Secreted.
Sequence:
MPRLVLVSFLFLAIFSVFIGGFAKSKCPRNEIFTRCHAACQPSCARLARKPFCIKICKPGCICTSGYLRNKNNVCVPRSRCFSGRLL
The following text describes a protein:
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Activity is required in glutamatergic neurons to mediate nicotine-induced and nicotine-motivated behaviors.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MLLPILLHFLLLITQLNGSPAEVRLINDLMSGYVREERPTLDSSKPVVVSLGVFLQQIINLSEKEEQLEVNAWLKFQWRDENLRWEPTAYENVTDLRHPPDALWTPDILLYNSVDSEFDSSYKVNLVNYHTGNINWMPPGIFKVSCKLDIYWFPFDEQVCYFKFGSWTYTRDKIQLEKGDFDFSEFIPNGEWIIIDYRTNITVKQYECCPEQYEDITFTLHLRRRTLYYSFNLIAPVLLTMILVILGFTVSPETCEKVGLQISVSLAICIFLTIMSELTPQTSEAVPLLGVFFHTCNFISVLATSFTVYVQSFHFRNQHVHERMDFWMRFILLEWSPWLLRMKMPDRENNFQTLTESWKGRNRRESMARTAFEYADGPVTQIHSMGIMLKDNFEELIYQVKQEKIADEKGIERLRVLQKIYDHVKMIREHDDDNDEDSRVALEWRFAAIVVDRLCLLAFSLLIVVVSIIIALRAPYLFA
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MQHRHEIFTAHHNSSIHSTSPGTDEQSFAGETTSTCDMRQKSDLGSQTPSIDSRTRFSCDEPVVNQNCFAEHKGSMFNEPFESKSKIDINEEYSYLSLDEHNGVANVNSLPEKSSLKSHFVTWDEKTEILKSENIELFDDKHGKNVRNPEYTVDISSQPQDISVRDRSLPHDNDLLLNTGNMSASFLRTNHHEEITSETDNYVDAMNSLESETETDSEFQTIREVKPSSIKNTQNDNLASDLCLTDCSNSESFEGRMLSLPRDMHKEFSSKLLIPTSFDAADHSSAILSPDEIVSVGTDIGGVKGRHLLENSGPIDINSEQSFPSNISELQIISPRCSEDKKGLDMTHMNNSSETYECSEKPTIKIWSNGRLLGLAPSKPSDFVVPSTTNQVSASNISLSGCNYSGSIVSTELHNDESSEKDKAFDSSDESLLKNPSSNIEACGSTKSITSCAGSMVVKEEHNTELVHSQIVCDKFANLQSAIICHRGQNEIGKEINPCDIESSTPSIEIHSTDLNPAEDTYITSSLPGLARKFLASNLHKRPLFDYKQRLPFSTIPTSNAMVLQERSFSDNNRKLLDKIESPLHHESVKYSNKNHESLVDPIIDSKYCGSPPSPPLEHMKISFHPINNNDISKLKLEFPDGHHHENIEELMFPSFQLFQGSVAYEHHLSSDSDDTFCRSSPAYSENIPIYHSDSDFELWEAEEQLKSGKDNMLDMPHCIASSTVSTSISSSLDFNKIKHDSIKSEIDKEISRVEESGMGIFQSGHVLGLPYLESLELPISKKDGKYLGNCDPQEYLLNAANDNSLLAPLPPLPPIQWRTKNSFIHSEVSQNCRSGLPNSSCNIEPQFLVKQPSQQIPCKPPPQLSHVQNPTSHQTMSMIVCHKINGNKGDHDSNAKELDEMGDFLHQIRSKSFNLRRTVTTKSDLPSGPTANNKVAAILEKADAIRQAVVSSDENWSE
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
Sequence:
MYIAGVMSGTSLDGIDVALVHIEGSGVDSKIELIHFTTVPFCNDMKNEIQQALSIETSNVQLICSLNFKLGLCFANAVKEVCKEANFPLRQLDLIGSHGQTIYHQPKQEGNIISSTLQIGEPAVIAYETNTTVISNFRTMDMAAGGQGAPLVPYSEIILYRHQTKNRLLQNIGGIGNVTVVPSKRSKESVIAFDTGPGNMVIDEVCQRLFHVPYDQNGWIAKQGVVVDEILTYCMNHPFLNMKPPKSTGREQFGEAFVTELLNRFKKHSKENILATVTMFTACSIVHHYKAFILPYYEIDEVILGGGGSYNNTLVEMLRNGLREEKCSICIQEDIGHSSAAKEAIAFAILANETYHRNPSNVLSATGAKNSVILGNITFPPYADENEANI
The following text describes a protein:
Function:
Involved in the degradation of 4-hydroxybenzoate (4HB) via the protocatechuate (PCA) 2,3-cleavage pathway. Catalyzes the conversion of 4HB into 2-hydroxypenta-2,4-dienoate (HPD). It is highly specific for 4-hydroxybenzoate, and is able to utilize both NADH and NADPH as electron donors at approximately equal rates.
Sequence:
MRTQVGIIGAGPAGLLLSHLLYLQGIESIIIENRTREEIEGTIRAGVLEQGTVDLMNQMGVGARMMKEGHFHEGFELRFNGRGHRINVHELTGGKYVTVYAQHEVIKDLVAARLQTGGQIHFNVGDVSLHDVDTSSPKIRFRPNKDGELQEIECDFIAGCDGFRGPSRPAIPQSVRKEYQKVYPFSWLGILVEAPPSAHELIYANHERGFALVSTRSPQIQRLYLQVDAQDHIDNWSDDRIWSELHARLETRDGFKLLEGPIFQKGIVSMRSFVCDPMQHGRLFLAGDAAHIVPPTGAKGLNLAAADVQVLARGLEAYYKAGKMEILNRCTEICLRRIWKAERFSWFMTTMLHRDQGHTPFERGIQLAELDYVTSSRAASTSLAENYIGLPMEF
The following text describes a protein:
Function:
Has several reductase activities that are NAD(P)H-dependent and involve FMN as a cofactor, ferricyanide being the best substrate for reduction. May be involved in ferric iron assimilation.
Miscellaneous:
MISCELLANEOUS: Present with 1270 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKVGIIMGSVRAKRVCPEIAAYVKRTIENSEELIDQKLKIQVVDLQQIALPLYEDDDELIPAQIKSVDEYADSKTRSWSRIVNALDIIVFVTPQYNWGYPAALKNAIDRLYHEWHGKPALVVSYGGHGGSKCNDQLQEVLHGLKMNVIGGVAVKIPVGTIPLPEDIVPQLSVHNEEILQLLASCIETTRNK
The following text describes a protein:
Function:
Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cell projection, filopodium tip. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus membrane; Peripheral membrane protein.
Sequence:
MMGEERSLGVSQRMMSPSRSTSSCSSKLGSRQTNHIHPQKTVELIKNLWVRRRQLKNHNICLACDKAALNTKTLCGECLQKAGSDSSSKFQTPWMDSWEIVEGLRSSTNYVQEPEKQEGFLLKKRKWPLKGWHKRYFFLDKGILKYSKSQADMERGKLHGCIDVGLSVMSVKKSTKCIDFDTEEHIYHLKVKSPEVFEEWMLRLRDHRLYRQNEISSVFPHELNAPFFPMISTTESASSAFDTVPSPQDFNRKNSLKLGNNLPFSCVNNDARVPSWLQSSDEMEKCAKELSQCHSYIVEMSNLLQNMEVLHRTYSAPSINAIQLGTIESPKKEKGIHRRKWRSKGLNKDSKGSLQVPSGVMRLHASNPNLSTIDYAEEKQYSGGLENSEFTKMQDNLCHIANKVYFSLKSAYNTVFSEREKLKQFLEHDSSLSAPIAGLKNALSSDSLCEEGKTLVHQLSNESRLSITDSLTEFYDAQEVLLSSSSSENEVSEDDSYISDISDNASEDNLSNDIDSERQSLNGGSVITVDGSYKHRTSLPATCPNTGNISLWNILRNNIGKDLSRVSMPVQLNEPLNTLQRLCEELEYSSLLDKAAQTQDPFERMVYVATFAVSAYASSFYRSGSKPFNPVLGETYECNKEDQGFRFISEQVSHHPPISACHAESENFVFFQDMRWKNKFWGKSMEIVQIGTTHLILPRFGDHYQWNKVTSCIHNILSGQRWIEHYGEIIIKNINSDICHCKVNFLKAKYWNPNVHEIEGTIMDRNGKVVHRLFGKWHESIFYGSSSAPTCIWRANPMPKDSELYYGFTKYAFQLNEIDPKIKCFLPSTDTRFRPDQRYLEEGNTDAAEMQKERIEQLQRERRKVLEENSLEHQPRFFRKTSDDSWVTNGTYWQLRKDPGFAKIDCPVLW
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.
Subcellular Localization:
Nucleus.
Domain:
The JmjC domain mediates the demethylation activity.
Sequence:
MEPEELTIEWYEENGLEKPIHFRCDPTRIGMKLPSPSTFTVDSVLELVGGNRMIEVVQVEDQGSVKMTLEEFVEFYKTPRDQRKNLYNVLSLEYSLTPLEDLVNSPALVRQIDWVGNIWPDALRQRWISFNGREKKSYFPHHTFPKVQNYCLMSVANCYTDFHIDFSGTSVWYHVLKGRKVFWLIPPTATNFFIYQEFIKTVSDNAFFGRSVEACHVAVLEPGDTMLIPSGWIHAVYTPDDSLVFGGNFLHSLSCQTQLRVYQVENKLNITRKFRLPYNEELLFYVMADYVKKWTGREYVRPLLVEDAKLDYVGEKWKAAGGHLKKIRFEDYNVEVTSEMVKNEEESEKDEVKVIAMHAGSSNYDNAMISKMSYTEATGLEEEAEDEDVKPETKKEAEERRDAEIDLLAATNSLIFYRNSKHDFIRNKSVPDHKLPIGHEPPVYFNDEEVSRISPRLLEELEALGAYIRRKNRVEVAEGICHPASLINLFNTVLKKRRAELTGKPFQFNQIMPRRYTRAAIETGDYDFEPVRTIEDSRRASQFKVEDFPDELLESDEPDETSRIHLPHQPSSGPLEYIPTPRGEIRENSLGFEPEYDEDMEEYDPAEQVVKEELEEEEEEEEGEEEEEEEYVAPVTRRSSTRGSASTKEEPQEEKEEKEAAPKKEKKEKKVKKEKSSKPEKDTTEAKLKKEKKKKEMERRLRDSELEAELRAAHGGKNAKSKKKPEKPAYVGGLPTAPIQNDPVVSNPYNYDPRMEMMKLGTGQLKSAYRKTKANVELHIEKNLYKLEPKRDESESREPSMEHEDSPTTPHAPYDRYSHYHTENSHFQEDQDSHRTPAKRSKYDNISVDTSESPHIPKKRSLEGRPSPYSVISPPHNRPKLSSPAMFSPSSEPRRSNDRRTSDPAVNAMKKGVYMPPMSRQDKMIAEAASASSSRHSSFSERRPSFIPDLNSSRHSSTDTPMYTPTAPARSSWLPNTSNVTRHSLDDDSPIDVVSESPIDVLNSPPFPRSITPPPVSLSELKSQSNGRKSNYSEDGKRAKIPAREAVAELKTLIGKLKTLNEA
The following text describes a protein:
Function:
Essential for cell growth. Plays a role in assembly of 60S pre-ribosomal particles in the nucleolus. Also required for replication of the M1 double-stranded RNA of the L-A virus. This latter function may reflect an enhanced requirement for free 60S ribosomal particles for the translation of viral mRNAs which lack poly-A tails.
Miscellaneous:
MISCELLANEOUS: Present with 3730 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus. Nucleus membrane; Peripheral membrane protein. Note=Membrane associated.
Sequence:
MSAIGDKNQFRIIVGSYEHNILCLSLDIPNQKENDAAKTPHFMPIFHFQAHSLSIKCLAVSRRYLVSGSNDEHIRIYDLQKRKELGTLLSHQGSITALQFSHPASSSEDAAVSKGSKNSKWLLSASEDHKIMVWRVKDWETVGTLKGHTARVNDVDIHPTNRIAISVSDDHSIRLWNLMTLRNAAVLKLRKYNTNGTCVRWLGAKGDYFAVGLRDRVLIYETGSAKVFKEIVFQRKTLMHIETHILPFDNKEYLSVGISDGNVHFYPCEELFEKVEENEKQEDDDDKEDISPAFSLLGHTNRIKDFKFYTNEFGTYLVTIGSDGKIVVWDMSTKEQVAVYDCGERLNCLTLCDESIEKYNTMKKRDAETADIGDQSEVESDTEELKKIMFGEKKKLNKKKRKQLKKSKVSVELE
The following text describes a protein:
Function:
Probably involved in ribonucleotide reductase function.
Sequence:
MLVAYDSMTGNVKRFIHKLNMPAVQIDEDLVIDEDFILITYTTGFGNVPERVLDFLERNNEKLKGVSASGNRNWGDMFGASADKISTKYEVPIVSKFELSGTNNDVEYFKERVREIATH
The following text describes a protein:
Function:
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
Subcellular Localization:
Chromosome, centromere, kinetochore. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
Sequence:
MAPLTPQLLLQRGRPKTDRLGKIQSLNLSGLELLSEHLDPNLLGRLKKLKELDLSNNLLETLPANLGLSHLRILRCTNNQLGDVTTLHQFPELEELSLEGNPFLTVSDNLKVSFLLPKLRKVNGKDTASTCSQVESLDRELTNRVTALWQKFIATVNPEEEANKVQADFMRSAVRDVRYGPESLFEFTQWRVRMIAEELVASGGAQAHEANASVEHPQAAVGSKLRARKVTKRPDDDEISLPPTKRVRASPPAQTEDSPMDAAGGQAALHLEPLHFLQCHSRNNSPKDLETQLWACAFEPAREEGHSGATSQTVATCGGEAVCVIDCQTGLVLHKYKVPGEEFFSVAWTALTVATQAGHKKRWNMLAAAGLRGMVRLLHVRAGFCCSVIRAHKKAIATLCFSPTHETHLFTASYDKRIILWDIGVPNHDYKFQASQLLTLNCSSVPLRLCPVATCPDSFLLAGCEGGCGCWDVRLDQPQKQRVCEVNFVFSGDSEVSGQRVDGLAFVNEDVVASKGSGQGTIYLWSWSQTWASRGSQSVLPVVILAQLQWSPTSLAYFSLSTCPDKNLVLCGDEEGSVWIYDVEHLLKQPPPLETTLQPPTQLPS
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MDTAQKQRWAITLSYDGSRFYGWQKQADGVPTVQAALETALAQIAGEAVSTTVAGRTDTGVHATAQVVHFDTTAARPQQAWVRGVNAHLPEGIAVLHARQVAPEFHARFDAYGRHYRYLLESAPVRSPLLKNRAGWTHLKLDIGQMRQAAALLVGEQDFSSFRAAECQAKSPVKTIYRADLTQSSGLVRLDLHGNAFLHHMVRNIMGALVYVGSGRLSVEGFAALIQERSRLKAPPTFMPDGLYLTGVDYPEAYGIIRPQIPEWL
The following text describes a protein:
Function:
Involved in peroxisome biosynthesis. Seems to directly or indirectly sequesters components of the peroxisome biogenesis machinery.
Subcellular Localization:
Peroxisome membrane; Single-pass membrane protein.
Sequence:
MDFFRRHQKKVLALVGVALSSYLFIDYVKKKFFEIQGRLSSERTAKQNLRRRFEQNQQDADFTIMALLSSLTTPVMERYPVDQIKAELQSKRRPTDRVLALESSTSSSATAQTVPTMTSGATEEGEKSKTQLWQDLKRTTISRAFSLVYADALLIFFTRLQLNILGRRNYVNSVVALAQQGREGNAEGRVAPSFGDLADMGYFGDLSGSSSFGETIVDPDLDEQYLTFSWWLLNEGWVSLSERVEEAVRRVWDPVSPKAELGFDELSELIGRTQMLIDRPLNPSSPLNFLSQLLPPREQEEYVLAQNPSDTAAPIVGPTLRRLLDETADFIESPNAAEVIERLVHSGLSVFMDKLAVTFGATPADSGSPYPVVLPTAKVKLPSILANMARQAGGMAQGSPGVENEYIDVMNQVQELTSFSAVVYSSFDWAL
The following text describes a protein:
Function:
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
Subcellular Localization:
Cytoplasm.
Domain:
The PRC barrel domain binds ribosomal protein uS19.
Sequence:
MELLIAGKVLGSHNLKGEVKVISDLDNIEVLVGNKVILELADSQQKLLTIKKIEHLVANKWIFSFEEIKNKQDTIEIRNANIKVRRDIVGIGEDEYLVSDMIGFKVYDVKGDEYLGEITEIMDTAAHDIYVIESEEFETMIPDVDVFIKNIDFENRKMLVDTIEGMKESKVKK
The following text describes a protein:
Function:
Transcription repressor involved in cell wall damage response. Regulates 79 caspofungin-responsive genes, including several cell wall biogenesis genes such as CRH11, MNN2, and SKN1. Also controls the expression of pathogenesis and hyphal related genes and represses the yeast-to-hypha transition. Mediates the response to oxidative stress.
Subcellular Localization:
Nucleus.
Sequence:
MSSDHKSKFDLELNPFERSFATKESSSVSLNELAAASNNDAISDVNSVATSGSSINNGSSSNKHNLHIPNISSVNQQQGVNGKLPGITPPLFTPGGRRLPPIGLSPGGTTSRQYSNSTNSGSLQSNTDTLGSNIWGGLPTNQTFQPQPQPQPQPQQQQQPQQQQQTQQPHNFNQFMSGMRKTGLTPNESNIRSGLTPGGLTNFGFGSNLVPGLSTPGALLNGPITPGLSSLLGITQTPSSLLVPTTSSFSQNNQSHLIQPAANTSVGPIPESTALGPHVNIPQANQLQQDQSSQALVGGLPPSQPQPQPQPVIAQQIHTIPENQSIAFDMTQPAVANAHLPESKPDLSETANLQRDLNPTADTTTNTTTATKKRKNDTAGGTNKKAKVAKGKKKEPKSKSKGKNNQEDDQNASNKPEDENVPGKENGNEENHKVEAESKEEHLQNGNETTTTKTNNTGNSSNGTTTTTTTKSKSKKNSNVSEDDKRKNFLERNRVAASKCRQRKKLLIQKMEEELEFYSNGYRELSAEVNELRGAILLLKEKHNIQDEIIDGLLSKPTTVPTNVTSIPSTIPTTLNPT
The following text describes a protein:
Function:
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Sequence:
MKYPPVHYHDYLGLNPLLNAQHPKSTEYGKPAHDELLFIIVHQTYELWFKQILFELDSVLSTFQKPTVAESEMGIASARLERIVSILKLIIGQVDVLETMTPLDFLDFRDMLYPASGFQSYQWRLIETKLGLRIGDRLAYNQSPFYKSLSESQQGEMLNIMNQPSLHDSVEKWLERTPFLQGENFNFWDSYKEAVNKMFQDDITTVKNNPRLPDEEKAKTVAGLEQTLKSFDALFDEEAFNKLRAEGQFRLSYKAMHAALLIQLHRDQPILQTPFRIIRALLDIDETMTTWRYRHALMAMRMLGQKIGTGGSSGHKYLADATAKHKIFGDFFNLTTFFIPRSQVPPLPKAIADRMSFHY
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MYSPFRKAKGEMGGGNSKSRWKIFIYRSSSSSASSSSKFDKKDPPKELLCPIYGSLMYDPVVVSSGQTFERTSVQVCKDLGFKPQLPNGSTPDFSNVIPNLALRTTILSWCEKSGAEKPRPPDYYAVESTVRTLVPSSSVSTTKEDPRIRVSERELLKSVAENPPMLLSHAASELTPRNNHHFYSPSSSEESVIANNSPLLPFTTRPSCYSSSSSQSTSSEIIVSDEVPSSASTSSEDDYYVVQFKKLDVYDQEQAVISLRKSTRTDEEARVSLCTPRLLSALKPLMVSRYASVQTNAVAAMVNLSLAEVNKVRIVRAGITPLLIDVLKGGFEESQEHAAGAIFSLALEDDNKTAIGVLGALQPLLHALRSGTERTRHDSALALYHLTLVQSNRAKLIKLGAASTLLGMLKSGDMAGRVVLVVCNLAVCQEGKTALLDANAVEVLVGILRKGSELDESTRENCVAALYSLSHGSLRFKGLAKEAKAAEILQTVVERGSERAREKAKRMLISMRGRYKEEDDEEEVDWEGVLEGRVSRIQYRVGRTTHNLNSTEF
The following text describes a protein:
Function:
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MNRRYKDRPEQRDEGPLIHIGKFLHPCTNDGYNVAVLESTNRDLVPKFNSPVYNDKGADVGIIDEVFGPITGYYFTVKLHPNVTPKGFAVGQSFQMREGRTMPLSRFTNPPPPPQRQAKQGGAQKRPQGKPAGKPGKPNDRRRDSKGPNPFSFTRDGGNPSRDRQGPRPGSGVTRNRFSHGRV