lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. Required for cortical neuron differentiation and callosal axon elongation.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKRLRVDETLKEGSVSPATAALYSVNQQQHQQQQSTTTSSSSTLSYSSASNVKVVSEGMQSGLYPPPPVSYGAMPTATAPHSGKASAAMQPLSVGGGGGGGGGGGGGGHTQLRTSAGSSPPTAPPIQEMQQQSQQQSPGSNFQRLKVEDALSYLDLVKYKFGSKPQVYNDFLDIMKEFKSQSIDTPGVIQRVSNLFKGFPDLIVGFNTFLPPGYKIEVQKSDQGYAFQVSVSMPSPTGNMPSDPQQQKMIMRGSGTINMSNSASVLNTLPPCQPLSLTQHIPTVQAQTAAPAIPPPPVPVHHSTSSYGTGAPTYNNSSMTLAAAQVAVSQALQGHTDTPQNQPVQFNHAINYVNKIKNRFQDQPEKYKRFLDILHIYQKEQRTMKESSGGGSGGKHLTEQEVYSQVAKLFENQSDLLAEFGQFLPDATSHINPAPISDHSVVKKPPTKQPYRENIMDRPSHKPSHHISGQLKRSPTYTPMMHRDAPPPKKHKMSSCRDVTLAEAGKYGTLNDYAFFDKVRKAVRTQEVYNNFLRCLILFNQEIISKSELIMVVTPFLGKFPELMRWFREFLGQNEVEPMPYNATRTERPQGETALEIDLTTAKRLGASYCVIPPSQEGLTCSGRTQLCKEVLNDQWVSFPTWSEDSTFVSSRKTQYEEYMYRCEDERFELDVVIETNASTIRVLEGVNKKMSRMNAEDVAKYRLDDCLGGSSPTLHQRALKRIYGDKAQDIIDGLKRNPQTAVPVVLRRLKAKEEEWREAQKGFNKIWREQNEKYYLKSLDHQGINFKQTDVKALRSKSLFNEIETLFDERHEQNEEGAEPVVGPHLVLPYKDRTILDDAANLLIHHVKRQTGIQKGEKRRIKHLLRQFLPELFFHPKQQLTDDERDDDEKEDGDDSPISSPTGNNSKGKSESSPGKSPGRLDGEVEVKTDPDCKDEDIKVPLHAQVSDPDEAYTLFMANNNWYIFLRLHAVLCERLAKIYERAVILAAEEAKSRTGRKESTAVALRLKPKPQIEVEDYYVAFLDMVKNLLDGNMDANTYEDTLREMFGIHAYIAFTLDKVVSYAVRQLQHCVTERTAIACTDLFVKEQKRGATGGSCSTAHKRAHLEMAYQRLGEKAVQDENCFKIYIYKKDCRMTIELLDTDSEDPKKVEDTKKWSSYKECYADITHVDNKPRSPVYLNRNLRLYKKRMGLHNKTSSVVEKKNKQQREENDEQKKNQDEENKKTNRATTDEADNKFAMLEELERKFSECPLPERNQTEHPGYEVSDETQCKFNSQDPKIMFTVNKDSYLYKISAFSRARKSHPAITKRLSCKFRAWLKHWASENVSDVQHKQCTDWLMGRGENVVPNRTRVLTDNDLSRTPYVPYNRYRVERLNEDVTAT
The following text describes a protein:
Function:
Putative receptor whose ligand is not yet known.
Subcellular Localization:
Nucleus.
Sequence:
MMEAPAVPGANPHHSMDILDEIFGSEWSAGQQQAADSQQQQQQRLLVGGVDTRTELVVRRKGGGGESGGQPPPGVPPPLQSIHQHHHQQQQQQQHPPTCLTPGPTLSQHSTTVESCFSPAAPSSQETSSVVDDNDNEAQDISEHEHNNHNNLQSKAGSDFAADTTTPPPRRNSNNSIRAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRQKNCVVDRVNRNRCQYCRLQKCLALGMSRDAVKFGRMSKKQREKVEDEVRYHRAQMKAQQAETSPDSSVFDNQQPSSSDQLAPYTGGYGGDMSPYTPSGYGFTPTPHTNQGYDISGTTDYVDSTTFDPRQTPIEPLPDSNLVSPISELLAKTIGDAHSRTCLFSGEHIADMLRKPQDISKVHYYKNMAQEELWLECAQRLTAVIQQIIEFAKMVPGFMKLSQDDQIVLLKTGSFELAVLRMSRYYDLSQNAVLFGDTLLPVEAFLTPDSVEAKLVSAVFEFAKSLAELKLSEIQLALYSAFVLLSSDRMGLRGTLEIQRLGQAVLRALRLELSRTHRTPLKGDISVADSLAARLPALREISGLHMEALARFKRATPHLEFPALHKELFSVDS
The following text describes a protein:
Function:
Spermidine transporter that is also used by salivary gland-secreted histatin 5 (Hst 5) to enter into candidal cells. A major component of host nonimmune defense systems is salivary histatins, a family of small (3-4 kDa), histidine-rich, cationic proteins secreted by major salivary glands in humans and higher primates. Hst 5 is the most potent of the 12 histatin family members and has fungicidal activity against blastoconidial and filamentous forms of Candida albicans. DUR31 only functions under high concentrations of Hst 5. Hst 5 cojugates to spermidine to be uptaken by DUR31.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAQLSSQGNNAIIYLSYAFMLATGLFLAWKFSSNKDFLSSNGTQRGIPLALNFVASAMGVGIITTYAQIANIAGLHGLLVYTICGAIPIVGFAVVGPVIRRKCPDGFILTEWVRHRFGMVTALYLSAFTCLTMFLFMVGELSAIRSAIETLTGLNALGAVIVECVVTTIYTFFGGFRVSFITDNFQGVCVLLLLIICAAGMGSYIEIDTSKIGPSGLLKANKLGWQLVYILFVAIVTNDCFMSGFWLRTFASKTDKDLWIGTSIAAFVTFAICTLIGTTGFLAVWSGDLIVGDENGYDAFFILLSKMPRWLVAFVLIFCIVLSTCTFDSLQSAMVSTISNDVFRNKLHINYVRIMLILIMVPIVVLAVKVADNILQIYLIADLVSAAIIPSVFLGLADTWFWYLRGFDVMAGGLGALLGVFIFGTVYYHSAREGGKLLLIWNGLYDSSDWGPFGAFVIAPVGGVIITLASAALRIAVLYAYSKVTGKEFTALDKPVTVEVENQDHTYGSIDDDESDTKKVV
The following text describes a protein:
Function:
Might regulate the synthesis and function of enzymes involved in later enzymatic steps of Krebs cycle. Loss in activity results in sporulation defect (By similarity).
Miscellaneous:
MISCELLANEOUS: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
Sequence:
MSNIAKGLEGVLFTESKLTFINGSEGILTHLGIPIQEWAEKSTFEELSLALLDAKLPTAEELAKFDAELKANRAIPDQLVGIIRDMPKGVHPMQALRTAVSYLGLLDPQAEDITPEARRAISTRMIAQFSTIIAAINRAQEGQDIVAPRADLTHAGNFLYMLTGNEPTPEQARLFDIALVLHADHGMNASTFTAIATSSTLSDMYSCMVSAIGALKGPLHGGANEAVMTMLDEIGTVDKAEAYITGKLDNKEKIMGVGHRVYKYFDPRSRVLRDYAEHVANKEGKSNYYQILEAIEKIIVDRMGAKGIYPNVDFYSGTVYSDLGIKKEYFTPIFALARISGWCASVIEYSQDNRLLRPDAEYTGARDQHYVDIKDRQ
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MNHHNITPMNFQQFPHLFLQEIPILGNSSVMKANIKKEEPSCAQMTIFYDGKVIVFDDVPADKAKDIMDFSTKGIASTSQNHNNNYAYSSFLSRNSLQDYPQVPSIPVIYDLPMTRKASLHRFLEKRKDRIAAKAPYQTSNPAAFLNKPIDESMSWLSLAPQSECSSTSVLFL
The following text describes a protein:
Function:
Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MEPTTSLRSCPIASLLFFLVLSLFVLVSAQFTVIGPAEPILAMVGENTTLHCHLSPERNAEEMEVRWFRWRFFPAVLVYRGHQERPEEQMVAYRGRTTFMRTDISKGRVALIIHNVTAYDNGIYCCYFQEGRSYDQATMKLMVASLGSEPLIKMKTLEDGSILLECTSEGWYPEPRAVWRDPYDEVVPALEEEYTADREGLFTVTMTIIIRDCSVRNMTCSVNNTLLSQEVESVILIPESFVPSLPLWMVAVAVTLPVVMLILLTSGSICLVKKHRRKKSILSAEKEAEYEEKEAARQLQEELRWRRTLLHAADVVLDPDTAHPELFLSDDQRSVIRGSSRQSVPDNPERFDCRPCVLGRESFSSGKHYWEVEVENVMVWAIGVCRDSVERKGEALLVPQNGFWTLEMFGSQYRALSSPEKIIPLKERLHRIAVFLDCEGGDISFYNMRDRSHIYTCPPVTFTGPLRPFFRLGSDDSPLFICPAFTGAQGVTIPEGGLFLYKTRPISQSLVRKP
The following text describes a protein:
Function:
Anti-proliferative protein.
Sequence:
MMHPLCARASMLPEISAAASFLSHLLRARGLVSDRQLQTFSQSLQDLLAEQYKHHWFPDRPCKGSGYRCIRINHKMDPLVGRAGQRVGLSAQQLFRLLPSELTLWVDPFEVSYRIGEDGSICVLYESPPAGGSGAQGPAGGGLAMADSRISCKEELLLGGASPSKSYAMMTVSG
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MQYQESPFSQFFYSIPIVTRVLFFTTLSFSIVGVFYPDLFYLCYFDREQIASGQVWRLFTPFFCQQLGFSFLIHMFMLYNFSKELEEEYFNNDTTDYIFYLLFNCCLLNILSVFVGPLHYYFISLFVYTASRANPNSIVSLSFGITLRRMYLPWALVVLNFILGAPILPQILIILVAHFYYFLRHVIPVHYPTLPRLV
The following text describes a protein:
Function:
Transcription factor that binds to DNA in promoters cis-regulatory element 5'-GGCGCGC-3' of cell cycle genes, including cyclins, cyclin-dependent kinases (CDKs), and components of the pre-replication complex. Binds to DNA in promoters cis-regulatory element 5'-AGCCG-3' of auxin regulated genes (e.g. PIN3 and PIN7). Together with FAMA and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity. Represses the expression of the mitosis-inducing factors CDKB1-1 and CDKA-1, specifically required for the last guard mother cells (GMC) symmetric divisions in the stomatal pathway. Represses CYCA2-3 in newly formed guard cells. Together with MYB88, regulates stomata spacing by restricting divisions late in the stomatal cell lineage thus limiting the number of GMC divisions. In collaboration with CDKB1-1 and CDKB1-2, restrict the G1/S transition and chloroplast and nuclear number during stomatal formation, and normally maintain fate and developmental progression throughout the stomatal cell lineage. Involved in sensing and/or transducing abiotic stress (e.g. drought and salt), probably via the positive regulation of NAC019. Regulates female reproduction being required for entry into megasporogenesis, probably via the regulation of cell cycle genes. Plays a minor role in lateral roots (LRs) initiation. Involved complementarily in establishing the gravitropic set-point angles of lateral roots by regulating the transcription of PIN3 and PIN7 in gravity-sensing cells of primary and lateral roots.
Subcellular Localization:
Nucleus.
Sequence:
MEETTKQNNMKKKKKILLHSDDSKKKERHIVTWSPEEDDILRKQISLQGTENWAIIASKFNDKSTRQCRRRWYTYLNSDFKRGGWSPEEDTLLCEAQRLFGNRWTEIAKVVSGRTDNAVKNRFTTLCKKRAKHEAMAKENRIACCVNSDNKRLLFPDGISTPLKAESESPLTKKMRRSHIPNLTEIKSYGDRSHIKVESTMNQQRRHPFSVVAHNATSSDGTEEQKQIGNVKESDGEDKSNQEVFLKKDDSKVTALMQQAELLSSLAQKVNADNTDQSMENAWKVLQDFLNKSKENDLFRYGIPDIDFQLDEFKDLVEDLRSSNEDSQSSWRQPDLHDSPASSEYSSGSGSGSTIMTHPSGDKTQQLMSDTQTTSHQQNGGELLQDNGIVSDATVEQVGLLSTGHDVLKNSNETVPIPGEEEFNSPVQVTPLFRSLAAGIPSPQFSESERNFLLKTLGVESPSPYPSANPSQPPPCKRVLLDSL
The following text describes a protein:
Function:
May interfere with constitutive 5'-splice site selection.
Subcellular Localization:
Nucleus.
Sequence:
MSGKSFRVSDGDWICPDKKCGNVNFARRTSCNRCGREKTTEAKMMKAGGTEIGKTLAEKSRGLFSANDWQCKTCGNVNWARRSECNMCNTPKYAKLEERTGYGGGFNERENLVYNEREESDGEYDEFGRIKKKFRGKTKKDSDKKEEPKKVDQDDEEEDDDDEDGDLSKYKLDDDDEDDDDDDDDEDDADLSKYDLDDGDEKKGSHSGSSRSSSRSSSSSSRSRSRSRSRSSSSSRSRSRSRSKSRSSSRSGKGSASSKKRSRSPSSSPEGGQKRSRSRSSSGGRKKRRARSHSSERRRGSSGSSHSGSSSKQN
The following text describes a protein:
Function:
Nonheme diiron monooxygenase involved in the biosynthesis of xanthophylls. Specific for beta-ring hydroxylations of beta-carotene. Also has a low activity toward the beta- and epsilon-rings of alpha-carotene. No activity with acyclic carotenoids such as lycopene and neurosporene. Uses ferredoxin as an electron donor.
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein.
Domain:
The histidine box domains may contain the active site and/or be involved in iron binding.
Sequence:
MAAGLSTIAVTLKPLNRSSFSANHPISTAVFPPSLRFNGFRRRKILTVCFVVEERKQSSPMDDDNKPESTTSSSEILMTSRLLKKAEKKKSERFTYLIAAVMSSFGITSMAIMAVYYRFSWQMKGGEVSVLEMFGTFALSVGAAVGMEFWARWAHRALWHDSLWNMHESHHKPREGAFELNDVFAITNAVPAIGLLYYGFLNKGLVPGLCFGAGLGITMFGMAYMFVHDGLVHKRFPVGPIANVPYLRKVAAAHQLHHTDKFKGVPYGLFLGPKEVEEVGGKEELEKEISRRIKLYNKGSSTS
The following text describes a protein:
Function:
Involved in the digestion of the blood meal.
Subcellular Localization:
Secreted.
Sequence:
MALNSLPIVLALVVLAQGASFGQDERLRYDNYSVYKVKFETQAQRSILRKLAEDRENFRLWHEAKDELHLMLSPGAFGELETEIQKTNVTAELFISNVQELIDSEEAANLKASRDGTFGWTKYNSLAEIYAWLDDILAAYPTITESFIVGQSYEGRTIRGIKISYKSNNPGVLIESNIHAREWITSATATWLINEFLTSTDELVRDLAENHDWYIVPVLNVDGFVYTHEKDRMWRKTRQPSEISSCIGADPNRNYDSHWMENEGASSNPCAEDYGGPKPFSEPEIQAMSEFVISIKDKINVLLAFHSYSQLLLSPYGHTKEEFPPNFDDMMEVAKAYGDAVESLPYGTVYRYGSAAGILYPASGATIDWAYNEQGVEISYTIEFRDTGRYGFILPPVHIIPNAEEALIGIAALLEKCKDLGYLGLKSAL
The following text describes a protein:
Function:
Plays a role in DNA repair and in cell-cycle control. Required for the repair of DNA double-strand breaks (DSBs), both natural and induced by genotoxic stress, by homologous recombination (HR).
Subcellular Localization:
Nucleus.
Sequence:
MADTSHLERMGRELKCPICLSLYNSAVSLSCNHVFCNACIVKSMKMDATCPVCKIPYHRREIRGAPHMDSLVSIYKNMEDASGIKLFVSQNNPSPSDKEKQVRDASVEKASDKNRQGSRKGRASKRNEYGKTKEIDVDAPGPIVMKPSSQTKKRVQLLQNLSAESLTKPTESVETAEKPKDYTENTVIRLDEHPSLNKEGNLSPFFWLRDEDDGENSSQRTESDQLLGTTPVNVPSFSDLMDSDHESPSKEDEQQKPNPGDMFDSEMFEWTQRPCSPEILPSPVKAKVLGRDEIDLTQKKLPKVKVASSKCKNRKAGSARNTVARRSIGVSQEDNMESSAAATISEQQDSRGTSGTIIRNDVNTDENVKAKRATRSKAQSTRVQSDLNVSNEADGKQGTKRKRSSIKSSPAHPIAGPNELSLGTEIVGKGDQDQAHGPSDTHPEKRSPTEKPSLKKRGRKSNASSSLKDLSGKTQKKTSEKKLKLDSHMISSKATQPHGNGILTAGLNQGGDKQDSRNNRKSTVGKDDHTMQVIEKCSTINKSSSGGSAHLRRCNGSLTKKFTCAFCQCSEDTEASGEMTHYYRGEPVSADFNGGSKVIHVHKNCAEWAPNVYFNDLTIVNLDVELTRSRRISCSCCGLKGAALGCYNKSCKNSFHVTCAKLIPECRWDNVKFVMLCPLDASIKLPCEEANSKDRKCKRTPKEPLHSQPKQVSGKANIRELHIKQFHGFSKKLVLSCSGLTVEEKTVIAEFAELSGVTISKNWDSTVTHVIASINENGACKRTLKFMMAILEGKWILTIDWIKACMKNTKYVSEEPYEITMDVHGIREGPYLGRQRALKKKPKLFTGLKFYIMGDFELAYKGYLQDLIVAAGGTILRRRPVSSDDNEASTIVVFSVEPSKKKTLTQRRSDAEALAKSARARAASSSWVLDSIAGCQILVLI
The following text describes a protein:
Function:
Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSRSDDQVRLQTTPNRTIGSLILLSTLTLFGLYTLWTIVLPFLPDDSPVHTWIPDRRWAITLPSLVLVVGLTTVGVYAGLLLREDALHQLAQEKPVLQK
The following text describes a protein:
Function:
Plays a crucial role in virus assembly into filaments and budding. Early in infection, localizes in the nucleus where it inhibits host cell transcription through direct binding to host chromatin. Later in infection, traffics to the cytoplasm through the action of host CRM1 to associate with inclusion bodies, the site of viral transcription and replication. During virus assembly and budding, acts as a bridge between the nucleocapsid and the lipid bilayer. Also plays a role in the inhibition of host interferon-beta response in a RACK1-dependent manner.
Subcellular Localization:
Virion. Host cytoplasm. Host nucleus. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=In the cytoplasm, associates with inclusion bodies. During bud formation, associates at the inner side of the plasma membrane of infected cells.
Sequence:
METYVNKLHEGSTYTAAVQYNVLEKDDDPASLTIWVPMFQSSMPADLLIKELANVNILVKQISTPKGPSLRVMINSRSAVLAQMPSKFTICANVSLDERSKLAYDVTTPCEIKACSLTCLKSKNMLTTVKDLTMKTLNPTHDIIALCEFENIVTSKKVIIPTYLRSISVRNKDLNTLENITTTEFKNAITNAKIIPYSGLLLVITVTDNKGAFKYIKPQSQFIVDLGAYLEKESIYYVTTNWKHTATRFAIKPMED
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLWQPKNVIEFATPIIKLWKYLGLPIYEVTGLRVTRQKSYFFPFAFLFLGVNISVYAVYYGVENSLRSWLSVCEFVAIQTQNVSFVLLAYWKRNQIPKFLAKCLATERRVSALSCTNFDFVGTGRQFLLLLIVKLLLVIFIFVIDCIFMARDFKDYIFRYCFYTGFVFYGASDFTILVLITPVEKLYGHFLNNLENHNLEESVRVFFMLQDLAQSTFNIIEEFMLAKILIDFFYASTDVFYGTASALEVQTSLLATVLSSFIVVLWLLFVVHSIVTISFVFGKVKEQHQVMNEIICERFRSKAAKNYRCEAKLLLRGKVNPLKFTICGFLPLDYCLAYTMTAGIVTYVIYLVQFSQVSHCVTCK
The following text describes a protein:
Function:
Part of the OsmU ABC transporter complex, which is involved in the uptake of osmoprotectants such as choline-O-sulfate and glycine betaine. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MHTLTLKRVLGFTIVILLLLALFIWGIGLETLKARQVDLLYLGQRHLMLVFTSMFFALLVGIPSGILLSRPAAKGFAEYVMQIFNVGNTLPPLAVLALAMVIIGIGDTPAIVALFLASLLPIVRNTYAGLCSVPASLIEAANGIGMTKWQRLRQVELPNAWPVMLSGIRIATAINVGTAPLAFLIGASSYGELIFPGIYLNDFPTLILGATATALFALILDTLLAWFGRRLSPHTV
The following text describes a protein:
Function:
Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end. The maximal velocity in an inverted motility assay (moving microtubules on fixed motors) was 1.96 um/s.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Local concentrations were found in vesicular structures around the nucleus in live cells.
Domain:
Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins, vesicles and membranous organelles.
Sequence:
MSSIRVVCRFRPQNKLELAQGGDSIVSIAPENDSVTINGSESNHSFSFDYVFPSNTTQRDVYDHAAKPVIEDIMAGYNGTLFVYGQTGSGKTFSMTGINDPNGDQELRGIVPRMIETVFEFISNADENIEFIVKASYIEIYMERIRDLLDTRKDNLKVREEKGKGVWVEGTSEVYIYREEDILDVINTGISNRAIAETRMNAESSRSHSIFILTIQQKNLKVGSIKTGKLYLVDLAGSEKISKTGAQGTTLDEAKMINKSLSSLGNVINALTDGKSTHIPYRDSKLTRVLQESLGGNSRTTLIINCSPSSYNEAETISTLRFGSRAKNIKNKAKINQERSAAELKILLSKAENEIENLKGYIKELETVSGVTVSNLKSSGSGSGSGSGSSSSSSGSSGGSGSGGSSNLSNSVNSTSNLNTSSNTSSSNVNANANVITTSVSAPTSPKDTELIKVLQEKCIQLEKQLFKKEEEKKEILEQLEQQQEQIQDKDQEIEGLNSMIESSNNINSLYQNSTNENSVLNVQLSELKLALEKSRFEATEQSLTIEGLNEENQSIKSQLEILKDRIAQSGDSSIASLVPSTPKSSAEMDPLATASKHADEWNEKAEQLKLLQRTPSKAVGSSKSNTATSSPIISLNISESDNIGSGATTTTNNNNATITPATSSNNNVEQQQQQVEELLPSVNEQLLESENQKLQKRIQEIELEFETYKIAKENLTMQKDLEIEQLLESQRISSSFVVDPRNLDDELPAEMMLQAEQIRKLIAENSEQKVHFEATKNENSKLKNRIEMIEEETRQRMEEELNVLREQTNQKLSEFGSLKESLIRDLENRCQKVIDLELVLDELQDRIVTLNERLKRVNKPGGGDQEAAFVQSKLDEITAVKHQLVIENNKHKTEVERLKKLLSHRGEHILILEKTMAINQESLFKLALNHNALTIEHDRAKNELEKLNNLLSQVGVDAQNTGGARVARVIRGGGGNNQLKKFNHSSSSSTSSSSALNHSSINNNHTTPTPLSANLYSNTKRSTKELNTGVKAEPLSLSGSPFNTSIPSSPNHTSSNNINNNSNNNNNNNNNNNIGNSGNIGGVGNNNSSISNSNNNSSSNLNANLNGNTPVKITSENSSSSLWNIFKKKSPSSTPPSSTNNLSPQSPQTPSHLSADGSGNISPNLSPPIPVNFSYTPAVVTSSTINKDQQKD
The following text describes a protein:
Function:
FAD-dependent oxidoreductase; part of the gene cluster that mediates the biosynthesis of the antibiotic 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA) and its derivatives. The direct non-reducing polyketide synthase dbaI product is 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA), produced by condensation of one acetyl-CoA starter unit with 4 malonyl-CoA units and one methylation step. The FAD-dependent monooxygenase dbaH is responsible for the synthesis of yellow pigments derived from the oxidation of DHMBA. The roles of dbaB, C, E and F have still to be determined (Probable).
Sequence:
MKSVLASGALTLAFSLAALAADAFQASSWDSTHIIRRDVVIVGGGAAGTYAAIRLKDHGKSVVLVERRDRLGGHAVTYKDPNTGGSVDYGVQVYDNNTVVRDFFSRLNTPLADLSFASFGKPVYADFEEGMLLNLTAGTLGQDYINELNKYPYLDNGFELPDPVPEDLLLPWVEYIGKYNIDLSTAIATLARPAVTGNLLNILAIYVFNNLNHLLLHEMSGAVVVNANRDNSQLYRNAVSELQPDLLLRSRVVAGQRRTRKRDGVRLVVDTPTGRKLIIAKQLIVGMPPILDNMRTFGLDSHEHSVLSHIYGLPYYGGVVSDTGLAPGFSFKNYAANTSYNLAEIPSVVAFNPSSVDGLFYYWYNAPQPVSQRRIETEARDAIKTLQRLTNSTTQPEPKFLAFSDFAPYQLRVSAEAIRNGFYDDMYGLQGHRNTWYTGTLFVTGSSQVWNNTEVMLPEILAAVNSS
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAEENISFSQRMISACSGSLVTSLVVTPFDVIRIRIQQQSILPQEQPCCQLHFPEHNFPKQKVPVEMAPELFWIHDKYCQSAKSCTRIYSTFQGFSTVAKHEGVRTLWRGLSLTLLMAVPSNIIYFTGYEYIRDHSPISNHPLNPLFCGSLARTLSATFVAPAELIKTRLQSIPTDSKSASHILFNLLRDSSAAVKKDGVRTMFKGLGITLWRDVPFSGIYWSSYEYFKAFFARTLKTDFNNPTRGGIDDWKVFATSFLSGSISGTIAAFFTNPFDVGKTRIQITMQENEKISHPNMFKYLYKIYKNEGMGALYAGFGPRVMKIAPACAIMISSYEVGKKFFKNGNNSN
The following text describes a protein:
Function:
Bilirubin reductase that catalyzes reduction of mesobilirubin and/or bilirubin to urobilinogen, a key step during heme degradation. Urobilinogen then spontaneously degrades into urobilin, which gives urine its distinctive yellow color.
Miscellaneous:
MISCELLANEOUS: Bilirubin reductase is a key enzyme in the human gut microbiome. The enzyme is essential to human health, as excess serum bilirubin can cause jaundice and even neurological damage. BilR is nearly universally present in the gut microbiome of healthy adults, while the prevalence of the gene is much lower in patients with inflammatory bowel disease (IBD) and in infants, especially during the first few months of life when infants are most susceptible to developing jaundice.
Sequence:
MRLLEPIKVGKIELKNRVMFPPMTTGYEGRDGTIVEQSFNFYKRLAEGGVSYIVLGDVAPVNTISPTPKLFHDGQIEAFRKLADAVHEFDCKLGIQIFHPEYDVEALAELFRKGDMEGGRAKMRHDMVHFIQEVTEEQLNSILDKIGECVKRAQSAGVDIIEVHGDRLIGSFCSTLINRRTDSYGGSFENRIRFALRVVDKIREVAPDICIDYKLPVVTENPLRGKGGLMINEAVEFAKILERSGVDMIHVGQANHTGNMNDTIPAMGTQPYCFMSKYTKQIKEAVSIPVSSVGRIVTPENAEALIENGVCDIVGLGRSLLADPDYVKKLEAGEGRRIRHCMMCNKGCTDAIQNRKFLSCVLNAENGYEYERTITPSDEKKKVVVIGGGVAGMEAARVASVKGHEVVLFEKETTLGGQLNIASVPPRKSEMNRALRYLTNEMKELHVDLRLGRTADAEMILAENPDNVIVAAGAHNVIPPIEGSKMPHVFDAWKVLNHEELPSGRVVVIGGGLVGAETAELLAEMGCQVSVVEMMEEIAKEESKTVRPVLFESFEKYQVQLLTGTKVTAITANSVEAENAEGKVSLPCDYVVLAVGARPNLFDVQALEDKGVQVSFVGDCNERAADINRAVEEGYLAANVL
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Sequence:
MAYIALPTRDSTLLRLANAAPRLPRSASATVQSTCSLKDVSSMRPLKVQPSSLFVSRTFSRYSTRGQTVFASMEGNVTVEEPAVDTTAEEPAADNTSVASDAAEQAEASETPKRFQRSKSSRAAKTLTVQKDQIVAGAVFTGKVRSVQSYGAFVDIGAFTDGLVHISELAPKFVKEVTDVVSIGQEVTVRVLELNEKAGRIALTMRDRENEEEEQSSRPGSESSAGSGSGGEESGRPVNRGKIAGRGSGGSRSNSRASEPKTKLKKGEELKGTVKNIIRNGAFIEFAEQGEEAFLRGSEVTEGGENVPMENLLTVGQEVTVRVLKVERGKAYLTMKPQVDMTSVNQSINSGVVGSAANPFATFFLSVNLAGAELVAAEGTPAMEETAAVEEVSAVVSV
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butanal, heptanal, and 2-heptanone.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSKLIEVFLGNLWTQRFTFARMGLDLQPDKKGNVLRSPLLYCIMCLTTSFELCTVCAFMVQNRNQIVLCSEALMHGLQMVSSLLKMAIFLAKSHDLVDLIQQIQSPFTEEDLVGTEWRSQNQRGQLMAAIYFMMCAGTSVSFLLMPVALTMLKYHSTGEFAPVSSFRVLLPYDVTQPHVYAMDCCLMVFVLSFFCCSTTGVDTLYGWCALGVSLQYRRLGQQLKRIPSCFNPSRSDFGLSGIFVEHARLLKIVQHFNYSFMEIAFVEVVIICGLYCSVICQYIMPHTNQNFAFLGFFSLVVTTQLCIYLFGAEQVRLEAERFSRLLYEVIPWQNLPPKHRKLFLFPIERAQRETVLGAYFFELGRPLLVWIFRTAGSFTTLMNALYAKYETH
The following text describes a protein:
Function:
[CLE11p]: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2.
Subcellular Localization:
[CLE11p]: Secreted, extracellular space.
Sequence:
MTKQPKPCSFLFHISLLSALFVFLLISFAFTTSYKLKSGINSLGHKRILASNFDFTPFLKNKDRTQRQRQSPSLTVKENGFWYNDEERVVPSGPNPLHH
The following text describes a protein:
Function:
Transcriptional activator acting positively in the phytochrome B signaling pathway. Functions redundantly with VOZ1 to promote flowering downstream of phytochrome B (phyB). Down-regulates 'FLOWERING LOCUS C' (FLC) and up-regulates 'FLOWERING LOCUS T' (FT). Binds to the 38-bp cis-acting region of the AVP1 gene. Binds as a dimer to the palindromic sequence 5'-GCGTNNNNNNNACGC-3'. Interacts with phyB in the cytoplasm and is translocated to the nucleus at signal transmission, where it is subjected to degradation in a phytochrome-dependent manner.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Cytoplasmic in darkness, and translocated to the nucleus depending on the light quality mediated by phytochromes.
Domain:
The VOZ region includes a DNA-binding domain and a dimerization domain. Contains an atypical zinc-finger followed by a basic region structurally related to the NAC domain.
Sequence:
MSNHPKITSAHQNVEEKLRELQERFCHLQAARKEGRHGDLALLEAQISQNIREWQAELTAPSPESSLLGEGISQFLEEFAPLLKLDEEDDATSTLKEHAGAKPDPEGFSQSLCPPEWTSENFSQSPFNGNFSCGFEDALNSTETHGQQLHYGYEGFDPSINSAPDFHDQKLSSNLDITSQYDYIFSEVRQELDNSPSTKLDSSEEIDNFAEFSTPSSVRVPPSAFLGPKCALWDCTRPAQGSEWYLDYCSNYHGTLALNEDSPGTAPVLRPGGISLKDNLLIDALRAKTQGKNVGIPVCEGAVNTKCPWNAAELFHLELVEGETIREWLFFDKPRRAYDSGNRKQRSLPDYSGRGWHESRKQLMKEQEGQKRSYYMDPQPPGPFEWHLFEYQINESDACALYRLELKVGNGKKSPKGKISKDPLADLQKKMGQFKVASDKPSPPTKGRKE
The following text describes a protein:
Function:
Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSGKNLKIYFGRSIRGGQKGEDARVFSMLVKELMKYGKVLTEKFGDDQAIQKEDAVTSDKAIYQADLTLIDQSDVMVAEVSNPSLGVGYEIGRAHDGNKKILCLYRPKDAPKKLSAMIRGADGINNLTVRDYEESAIPSILSDYFG