lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Central component of cohesin, a complex which is required for the cohesion of sister chromatids after DNA replication. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. Involved in chromosome cohesion during the cell cycle and in DNA repair it also regulates DNA replication. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis and in chromosomes movement (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity).
Sequence:
MFIKFIFIKGFRSYKDQGFTSITLHPGFNVVTGRNGAGKSNLFAAIRFLLGDLNVGNNSEDRLKLLHSYGGNTMQTGYVEIVFDNSDHRFPIDKTEFSLRRTFGTSKDEFSIGNNKLSKADVRNMFEAAGFSSSNPYYIVQQGKINTLALMKDSDRLDMLKEVAGATVYEERKRESVAIMIESESKSIKIEEFLKYIDERIKVLDKERKELQLYQTQIEMKKQFEAYIIHLEANESNDRILDLEKEKEKYLIHSSKESKKLERFTDELKKDESKFNKLLSEIKKIDNEKIMVEKLNEVFDKQKAQLVIQQKHFKKLLSKEQAKLEKLQKEQDLLSGSKEKLEKEIEIIKPKLEELIGQEDDIDNKLSSTERNLQELYVKQGMFQFKSKTERDKYLGDESSKLEDIVNQYEQQAQSLEEDVEDMKQIQQSKGKQFDNSMASKDKEAEIVKTAELRVHELKLEKDQIEQRVSSTFQSINEMKSNLTEHRNEWKKAERNLQTIMNRPLSEGLTRLNQIRQEGKIKGIHGPLVELFDIVEPEATLALEVVGGNGLFHVVVDTDDTASKILEILNTENIGRLSFIPLNRVRTKPPKFPILENDLVCPLIKVISFDPIYTEAMKLVFGKTLICKDEATAEQVRKSSHVDCITFEGDVFHSKGAVTGGYYSKKKLKLSSYQQIKHWRQQYQQLQTQLTEKESELEKLQASLLSIQKTIRTKEDEKNKILSNNDNSRVELDKIISERTMYIEILEKKQTILKKLKIDIQNCKDTIDGYQKQINTAFNTKLTEEESNLLLTLSESSIQLKEQKISISSDVMKLQSRKNQMTNQLNQNYGKRLMEIEGEIKSLNPENSKLQIELKQKEIDEINIEIDGVREKLESLVQSLNEKDAEIKPIKVSIDALKQQTSTIADQLVADGKKMESLLAQIQSFNKVRDAKQLRVLSKGDRFNFEELKKYNKDQSVEELNKINKSLASLRHVNQKANDQFNSFTNQYNSLEARRDELYESNASIQLLIKTLDNKKDEAIARTFSGVAKNFTQVFKELIPGGSAKLVMKRQMDEDEGEGEDPKEWADGETPKGLLTFTGIGIQVSFGEGHEPCSMRQLSGGQKTLVALALIFALQRTDPAPFYLLDEIDAALDHNYRVAVSKMIRKHSREIQFIATTFGPEFVMDANQNWIVVFNKGGSKLVPGSTEDALNVIKQLDNGSAFDYSYQGITEEEFNQDRPVLGVAENKHLVAFEFKRAKKRALKALAKAEEACAIMVQDEANQDSNADSSEKLKHDKKIFEKLHKEYLLRAAEFNQVKERFIRFGGIIKQQGDDELSQSSQPQDKEMENIEKEKDNNQQTSDTEMKDTDQSTTKQKSPPKRKSPSQDTSDIETSDDESKKKQTESNQEESDIDEETPSQRFEEALNYASQKLKQHGLQESEQSEQEEDDDDISSDSSD
The following text describes a protein:
Function:
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MGFTDAHALRPVVTTPFPAPNVMDLTMFKERKESMYWGTYRPQAYFGVRVRDPHPLVAGLMWLVSEQNEPVMRHFCEDKHGLKLFGWTEHNGTDYGQQDLVEKDLVLQTSFVKSKENMFGQVKLSDTAEDDSNVYVFQISTMSQFSTIDIAFISGIDEKTADMEDRTNTLTGSQLTTLLAEKHVAFDEKFRECFNLSEEQVEFKLVPKVRVYRTIVDPKSRVEIVCAEQVVGVYARQAMMMLRNVPAYAASEKLVEIATELELELVLISELAEESSSPPLMWPRSCRRNQMSSSELVILDTGHIFASRDTAIFSQGKDRACYGGTCPALLHHIHDNENGVEARALDERSVCLNASCSEDLLSLERVVKLLGWLLSCQVEIMNFTGRTFVKSSLVPNERLYRQGRELSSSHQRRNSKWTRQSRSSLSCKGSKAETFGLMWTSSVWSCLRANFTGGFQKLHRRIETEAAPRILYERRDETTSPLRIFGSLVWEEGGKFLLAWQRQYNRSRTKPSCNTVASGMDDYPRASHPSDGEMHVDLRCWIYLAADCMKFITTFLQRKKTEEDYSSIVHQLSDFDDLNKMHYDRDHKTYLDFGNHTEKVRLVIEFGRGIRVTDEEPELKKVPHVGYASLFPFMSKIIPPHSEILEQQLDLISSNELACSDYGLLSLAKTRIKQIHSFVIIKSSMQLFVHDTERSDEPTTMLERSHMDEYELHDSCLPQTLLFSNVVGEYDKTRYIWERYDQTKGTGEGGRNFTGWSALILLIMTEDYPRL
The following text describes a protein:
Function:
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MHSALVRLQNVFGFFTTVAFTVAAVIALSSFISPQTPRASISLRNVQVVKGRPHYYSYKKEEYANVRFDLDADLSTLFNWNTKQVFLYLKAIYPSPRASEPPSEAIIWDAILASSTAPWNQLHFVHPAKAKGVKDEKDLLFPRGELHLHNQRPKYQITDITGKLQNRTDVYLELGWNVQPWVGALTWTNWQKFGAWEGFKGGRSATFEFPEIGAKMKKVKKEDLETEKGSEGYRLMAGEEQPRKSV
The following text describes a protein:
Function:
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
Subcellular Localization:
Cytoplasm.
Sequence:
MMIEVLKSKIHCARVTEANLNYMGSITIDEDLLDAANMIPGEKVYIADNNNGERFETYIIKGERGSGKICLNGAAARKVQPDDIVIIMSYALMDFEEAKSFKPTVIFPDPATNSVVK
The following text describes a protein:
Function:
Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MIPNEKLKLLGLLSISFFLQWYLANTWIAEFLYRRIEVSTPVSGFLRVREGLYLYENGLDPYSGGVFYQSPLLLILNYCCELLGGISVTRFVYTSISTMGGLFVYLIAKQARVLDPNQVLSTCSPLWISVIYLLNPLTFLPGIACSADMILNFTTLMTIYFASCGSYAIYACCMALTVFINPNALLLFFPSYLILRKCNSSIKFRQIFVVFLFYLAGLIITSGFFLNSLSFLKIPFRVYLDSHDLTPNLGLWWYFFTEMFNEFRTFFLFVFAILPLMFVLPVSIRLYYLPLPITIALIGLHSLFKAYPSICDLSIFLSLLPIFNKVQDRMRYSLLTNNAIVFALVLGSAFYHSWITLGCGNANFYYASNLILALGLSLKIMDFLKALLLVDWYANHPQHENIPLKQVQ
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MEGDQNLISILSIDGGGIRGGIRGIILAVILNFLESELQKLDGPEARIAHYFHTISGTSTGGLITAMLTCPDEAGCPLFTAKEIIEFYLNEFPRIFHPPRSHFWKLPYLERVNTFLWGPKYDGEYLRNVVSKLLGERRLHDTLTNVVIVDYDTILKQLVIFSSHEMKKSPRLDAPLSDICIGAMVIPGYLPSHYFKTIDHLGNITKFNLCGLVANNSSGIAIGETISEVTGGIDSLVEARKHGQFLLLSIGTGIRDSLDESILYLIKALDAKVYYLQIQDDIWGGDLSSIGKATKENLLDLVKVGEDLLQKPVFKRNPESDRPYSKETYAEVLVRFAKLLSWKKREGRLNTDQKKKSFRNIHGRAEPIQEREGACRHL
The following text describes a protein:
Function:
Inactive ADP-ribosyltransferase that functions with SRO1 to regulate oxidative stress, hormonal and developmental responses. Required for embryogenesis, vegetative and reproductive development, and abiotic stress responses. May regulate several stress-responsive genes. Seems to play a larger developmental role than SRO1. Does not bind NAD in vitro.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing RCD1 show a weak rcd1 mutant phenotype; MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Subcellular Localization:
Nucleus matrix. Note=Speckle-like pattern.
Sequence:
MEAKIVKVLDSSRCEDGFGKKRKRAASYAAYVTGVSCAKLQNVPPPNGQCQIPDKRRRLEGENKLSAYENRSGKALVRYYTYFKKTGIAKRVMMYENGEWNDLPEHVICAIQNELEEKSAAIEFKLCGHSFILDFLHMQRLDMETGAKTPLAWIDNAGKCFFPEIYESDERTNYCHHKCVEDPKQNAPHDIKLRLEIDVNGGETPRLNLEECSDESGDNMMDDVPLAQRSSNEHYDEATEDSCSRKLEAAVSKWDETDAIVVSGAKLTGSEVLDKDAVKKMFAVGTASLGHVPVLDVGRFSSEIAEARLALFQKQVEITKKHRGDANVRYAWLPAKREVLSAVMMQGLGVGGAFIRKSIYGVGIHLTAADCPYFSARYCDVDENGVRYMVLCRVIMGNMELLRGDKAQFFSGGEEYDNGVDDIESPKNYIVWNINMNTHIFPEFVVRFKLSNLPNAEGNLIAKRDNSGVTLEGPKDLPPQLESNQGARGSGSANSVGSSTTRPKSPWMPFPTLFAAISHKVAENDMLLINADYQQLRDKKMTRAEFVRKLRVIVGDDLLRSTITTLQNQPKSKEIPGSIRDHEEGAGGL
The following text describes a protein:
Function:
Positively regulates flowering by repressing FLC expression and post-transcriptional modification.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MAEAEDQQNFVAHNGDQVPDQGSDELHNGLPYQVHDETLVHQPYEVEDPILEPQQYEVPDPTLEPQQYEVPDQTLEPQQYEVDDQLEYHQYQLQDQANEDVQDHSQDDLQYQPQNQEQFQLQDEAHDQAQYQAQGDVQDHNGDEVQDKVEDEEGIPEHLESLQKSEPEEDATVGGEEKRWPGWPGETVFRMLVPAQKVGSIIGRKGDVIKKIVEETRARIKILDGPPGTTERAVMVSGKEEPESSLPPSMDGLLRVHMRIVDGLDGEASQAPPPSKVSTRLLVPASQAGSLIGKQGGTVKAIQEASACIVRVLGSEDLPVFALQDDRVVEVVGEPTSVHRALELIASHLRKFLVDRSIIPFFENQMQKPTRQMDHMPPPHQSWGPPQGHAPSVGGGGYGHNPPPYMQPPPRHDSYYPPPEMRQPPMEKQPHQGISAYGREPPMNVHVSSAPPMVAQQVTQQMQIPLSYADAVIGTSGSNISYTRRLSGATVTIQETRGVPGEMTVEVSGTGSQVQTAVQLIQNFMAEAGAPAPAQPQTVAPEQQGYNPYATHGSVYAAAPTNPPGGYATDYSSGYGY
The following text describes a protein:
Function:
Probable sterol desaturase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLDLYPVQNLTVDQLEYEKNTRFLQPAWDWIKNGNEHILSSPLFPPFYALSIDYTWVAVFTFIDVFLCNVPFFKDAKIQKDRKVTWDLIKKSLKLQGWNQLLWIYPMALVQLIWVPDTELPILAPTVFEMLSQLAIFFLAFDFTYFWFHYINHKVKWLYRWCHSVHHMYSSPFAASAQHLHPFELFFVGTFITTIPWIFPTHCLTYWIWFFIAQSVSYEVHIGYDFPFALHRIFWFYSGAPAHDMHHLRPLTCFQPWFNYLDRLMGYHITYADLKKMTEAKFKKFGLYSAEDEKGLIKIN
The following text describes a protein:
Function:
Telomeric DNA-binding protein, which binds to two or more single-stranded G-rich repeat sequences (G-strand), with high specificity to the 5'-TTAGGC-3' sequence. In addition, repeat sequence binding requires a 3' single-stranded telomeric overhang. Acts redundantly with pot-1 to negatively regulate telomerase-mediated telomere extension. Also regulates telomere length by the telomerase-independent telomere maintenance pathway called ALT (alternative lengthening of telomeres). Does not appear to have a role in anchoring telomeres to the nuclear envelope.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MSSFDRRIEAACKFDDERYYKQYHRYFDVLAQVHSVVETINGAQMLRVWRGRKFGPGASAERRERRLFHVTQDSFKRYIVPPNPRIGKAIEENGKELLIEIDVYDDHRDGLKNLNSGDFVAIQNVHAASTRQTEMQVLHGGGASYQRGITTVPVDFEHEAFQNFKKKVEAVLETVAYDENFTEFQQPEEVAENHVDEEPQEEALPRGVVLRTETCDFMDMELDNWPEGPPKTFAEAIARANNSRRPRDPPQ
The following text describes a protein:
Function:
DNA ligase that seals nicks in double-stranded during DNA repair. Also involved in DNA replication and DNA recombination.
Subcellular Localization:
Nucleus.
Sequence:
MVTSKSRQRPHERSFFHPKKEGKAKKPEKEASNGIRETEPPPKVALKERNGVVPEGDSPVKRPGRKAARVLGSEGEEEDEALTPPKDQKPAPDSPKVSPPSPESTPALCSASPARVSPSGIPKRRTARKQLPKRAIQDVLEDQSEDEDREAKRKKEEDEAETPTESLTEPEVAKRKEVEEKDRPMTPPELPENSKPPTDSVAEPEGAVKQEPQEDQPQPPPRAPKTLSSFFAPRKPAVKKEVKEEEGSGAPRKEETKGPLDPPSYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPILYLSLNRLGPPQQGLELGIGDGILLKAVAQATGRQLESVRAEAAEKGDVGLVAESSRSTQRLMLPPPALTASGVFTKFQDIARLAGSASTTKKMDVIKGLFVACRHSEARFIARALSGRLRLGLAEQSVLAALAQAVSLTPPGQEFPPAVVDAGKGKTPEARKTWLEEQGMILKQTFCEVPDLDRIVPVLLEHGLERLPEHCRLSPGVPLKPMLAHPTRGVSEVLKRFEEAAFTCEYKYDGQRAQIHVLEGGEVKIFSRNQEDNTGKYPDVISRIPKIRLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDAAEIQVQVCLYAFDLIYLNGKSLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDTDQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLACYDEESEELQAICKLGTGFSDEELEEHHQSLQALVLPSPRPYVRADGAVAPDHWLDPSAVWEVKCADLSLSPIYPAARGMMDGEKGISLRFPRFIRVREDKKPEEATTSAQVAHLYWKQSQIQNQQGTDVDSDPEDFY
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSVLTALLLRGLTGLAWRLLVPCLDPFHWPWEQLRTIGLTSCFLCFLLPLVWVLSHLESYKKWE
The following text describes a protein:
Function:
Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.
Sequence:
MGKAAIGRQVAEPIVVSDEYMQYLTKLIPSTPELVKAGFVVSPLTPTELQAKVKCKNCHKRSPPPPSQFRPAVAIDCEMGVSSDFESELIRLSLIDYFSGQVLIDRLVRPNVPMQHMNTRYSGVTRQDLQNAIRNGTCIIGGLEEARKEVWKFVGPQTVVIGHSVRNDLSALRWIHNRCVDSLVVEEGVRKKIKAKEEEEEKEKEKVREKQKEERLLEISLHCGPGMAEETRRMMEEEEIKEKEKMKKMRGKRGEDGMSLKALTKKKLGRVIQDAGKKGHDSVEDAVAARDLIHHHILGLMQKDREKKEAESEVKGEAEAAFAQVLAEGTRDAEMGSVFAAFP
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide. Important for growth on acetate. As a probably extracellular enzyme, it may support a H(+)/CH(3)COO(-) symport mechanism and/or conversion of CO(2) to HCO(3)(-), removing excess CO(2) produced by growth on acetate (Probable).
Subcellular Localization:
Secreted. Note=When isolated from M.thermophila.
Sequence:
MMFNKQIFTILILSLSLALAGSGCISEGAEDNVAQEITVDEFSNIRENPVTPWNPEPSAPVIDPTAYIDPQASVIGEVTIGANVMVSPMASIRSDEGMPIFVGDRSNVQDGVVLHALETINEEGEPIEDNIVEVDGKEYAVYIGNNVSLAHQSQVHGPAAVGDDTFIGMQAFVFKSKVGNNCVLEPRSAAIGVTIPDGRYIPAGMVVTSQAEADKLPEVTDDYAYSHTNEAVVYVNVHLAEGYKETS
The following text describes a protein:
Function:
May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
Sequence:
MLKLAICDDEKTQREEIVGIIVEALRLKNKQYKISEFNNGEDLISSTDDFDIYFLDIKMDKLTGLEVAKKIRLINEEAVIVFITGLKDYVFDAFDVKAFHYILKPIDESKLKDVLCSALLQFDKKDKFIIAKTISQATKIFLKDIMYIESQHRKLKIHTKNNIIEYYHKISDIEKELYGCNFFRCHKSYIVNLKYVESYDNVFITLINSEKIYVSKYRLDDFSKAFMYYLKNEVQ
The following text describes a protein:
Function:
Required for peroxisome assembly.
Miscellaneous:
MISCELLANEOUS: Present with 538 molecules/cell in log phase SD medium.
Subcellular Localization:
Peroxisome matrix.
Sequence:
MFDHDVEYLITALSSETRIQYDQRLLDEIAANVVYYVPRVKSPDTLYRLVGALFRSQFIVQLPPLRLLHIVKDVFLWKLEVSEPTLPISKFYLVWNAVFESHRATWNLSQLMVLDGVLVTYPSFKQLNNAYFIDESSNKTALYYRNWKLQLFSPIWAQLWNTAIVRANLSIQHCLLIALALLFNQSNRSALLHGVDVSWNLVTEKLLDLLEEYVHGIVQPMEIFSTDSVLSTNLNHLASCLTSSITRSNEATLVNSVRKLERICRYLSDTVASLKEQQLDFKFQNVFILIILALKELSAMNMTILPNHKDTFYSMICLSLFHVHVLTQKIGTVGFPSYDYVYDNLVTYFIVMDDLSKITTVLELMKRNNTKQDPNKLVFYINFLNKITNYYGCRIRLPFITEFIEPLLHFDVFFSGKTGNTLDIEIKESIHTLTITVLSIDSSYSSQVAQWQVSRILVYLKMSMDQFIAGKLSANQILLIFGHLSTQLPSLHNYNKHLLRDSLHETYIRIVNVKNPEKKNVLIECLIVQIAFINNPHHLIGWLNICLQLINTHNKKLLQQLWEMVSSLESSLAIDWWYTTVLSSQSSKL
The following text describes a protein:
Function:
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRHCGVLLIVVYGLVILACLCGNGLVCIVVAKNRSMRTVTNYFIANLAVTDLLVGVFCTPITLIDNFQTGWEFGALMCKLLPTVQGIAYGASVFTLVAIAVDRYLAVTAPNDGKLTGMCTFCIILVIWLSAIIIMAPISFATKFDKDDKTCYEYWTFPDGTSCKIQIVSAVTSGLNFCFSTGHRLYTLALFVMCYLAPLVAITSLYIRIAVRLYNTSVRSSAHCGAWGTTGAASKLGYKVRVFKMLVVVVVIFTLLHLPLHTVTFLVDYGDLSCDVKESIFKYGYPIAHWLAFVNSCVNPIVYGCMNRNFRKGFASAFRRAGLPCCTLRRMNNLRNTSDKRRRSTNRTTPNAENLEDPAKLKGSPDTGEIELVAVPNDVTRRHNSHRCTGNAEPTVGVVSWISQV
The following text describes a protein:
Function:
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular Localization:
Cytoplasm.
Sequence:
MNFLSNQPSNINTALLEEVKKITSLIKTNNEIYNLSITSFSLFICFYKNNFIVFEENEDQAAKLYAAFKTFSSFFNTTDEIVFLPSKGTERMIAIFKILNERNKKIITTVDSAKIPPHIETINIKKGGTIEREFLAKNLINLGYSKVELVTQEGEFSEHGWVFDIWGIGEEYPARIEFFGDEIEEIKLFYPDTQRSFKDKNEIWIIQAEEKEINNIELLELFEFDNIFTVDKNFTNKKFNIVKISHLPVKFSTKSVDAGDKTFYGLGILPNERSSILDFPRNLKKLGIPIIFSISSRGKAETIKEVLFNHDIIAPLIHKNEIGTYSGKYAITISDLQEGFYRENLMIITDFELFGEKTLKKKKLAIQKLPIDGLEINEGDYIVHKEHGIGIFRGIKRQKYEGTEEDVLVLEYKDGDILYVPTWNIGKIYRYSAKEGFIPPIDKLGSNRWQKAKERERKRIHDIADKLIKLYAQRKTERGFIYSEDTEIHKNFDDFFPYEETEDQQKAIDAILKKMREPFPMEVLLCGDAGYGKTEVAMRASFRAVYDGKQVAVLVPTTLLCEQHYRTFKKRFEAFPVKIEYLSRFRSEKEIKKVIEDTKLGKVDILIGTHIIILKEVDFFDLGLLIIDEEQKFGVIHKEKIKEKYPKVDLITITATPIPRTLQIGLSGLWDIFVIQTPPKERLAVKTFVIQENELIIKEAIEKEIQRGGQIYFLHNRIHDIELVKSKIQKLVPMARIGVAHGRMKEKMLDKIMLDFIYGKIDILLCTSIIASGLDIPNVNTIIIDQAQTFGLSDLYQIRGRVGRSYRQANAYLVIPPEEILSEDAKKRIKAIQEMSYLGAGFHIALRDLEIRGAGELLGVEQSGVNRLGFDLYIEMLNEAVKEIKGEVLPALKLPEIKFSIPAFIPEEYIKETPMRIRIYRKLSQISEDSEIEKLYDEIIDRFGMPPKEVENIFKIARIRLLVSKIKASEVKQKKNTFKFKMEENLDTGFVNRLLHILTGFKNRGIIKNLKFYQDGFEVNIEELDGLILFLKRLIAKVEDKK
The following text describes a protein:
Function:
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
Sequence:
PDWESLDARPLPSWYEDAKFGIFVHWGLYSVPGVGSEWFWYHWRQGYPEIMEYMWRNYPPGFSYADFASKLKAEMFNATAWHELIAKSGASFCVQFYAHSIGPGYTCCSKYLRSIRPCIFSVGELASVFHMYGDIKFGLYYSLYEWFNPLYLKDKRKNFMTDEYVKTVVKPQLRELVNKYMPDILWADGDWEAKDSYWGSKEFLTWLYNDSPVASSIVVNDRWGRGCGCNHGGVLVCADRFNPVGHMMHRPWENAMTIDKKSWGYRRNAKLSEYLSTYDLIRELASTVSCGGNLLMNI
The following text describes a protein:
Function:
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Sequence:
MQDLIKRTLPQDDALNQAIVNDLRSQNWAGFLNYSQVQQLCHNFELTTLKLAMHLLPLAASYSHTAISHFNVGAIAIGEQGDFYFGANQEFANSAIQQTIHAEQSAISHAWLRNERRISDMVVNYTPCGHCRQFMNELHGAEKISIHLPHSQNNPLHSYLPDAFGPKDLDIAAHLLAEENHDLVADHQDDLVNQAILAANQSHCPYSNSPHGIAILFKNSDVVTGRYAENAAFNPSLPALQTALNFAYLNDKKLSDIERIVMAEKALKLSHKTMAETLLSTLTSVELEYYSL
The following text describes a protein:
Function:
Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi (By similarity). Plays a role in regulating Rab6-dependent CadN transport in photoreceptor cells which is required for the formation of normal synaptic connections between axons from the inner photoreceptor cells in the eye and postsynaptic cells in the brain medulla layer M6, and for the generation of normal postsynaptic responses.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Note=Colocalizes with Rab6 at the Golgi apparatus.
Sequence:
MYYPVGWPKRVGLALPGESASIRHICCDAVKILVAAVGDDFLGIWYANPLIPIAYFRRTEDSLRQYGANQLIVWKPDSRQLALLTASGSLLLYQLDFEANGMGILQQIDPPAASLKRDSAELFIKENIPRLSLRELCSVTLGSVITTVCCISLSELLLATQSCELLRLQWTELEHAENDLELPALSSIKLRDIPFYVQQQPQQSARNVPPLNRDSYVASLEYSPFIGGCAAVFSDRRAAFLIANHLRFETDHMHGFWVPDVEDASVCSVNHKFRLLAYGQESSAVKVYAIDDATGGLEFSHRLILTENILPDSLGSVNELKWSPDGCVLAVSWTNGGLSLWSTFGALLMSTLSWDFGLNVDLVCQNPLKIRRLEWSTEGYQLFMLKLHPEKDKSNVLQLQFVKSALSMNPCMTTSPHILLQGDDCLYLNQGNNLELTYAGSHGTFPSSGLGSDEDISGDGDCLELKQSPHTGSILTESKYWTVLQLPLNYAATNWPIRYAAIDPDGLHLAVAGRTGLAHYSLVTRRWKLFGNESQEKDFVVSGGLLWWHGFVVMGCYSLLDRTDELRCYPADCKLDNQYGHKLQVRAPVISLNSFRHQLIVLTADGIVSLFNMSKNSAYALDIECAYELDVKSICIHPACIVSLTVTNLKNELKPQGQLGGDQAETIIVNVCGRILMIQRDAGEQVPNTLLATCLASCVEVFWLSHSLERCAMRDCLWLYSGAHGMRVWLPILPPGRERREGEQGGAQRLHSFMSKRIMLSFPLKLYPLVVLFDNVIVLGVENESTLYANEQVSHFSLPFAVMERKSQIYLHKVLRQLIKRNLGYSAWEMAQSCCSLPYFPHALELLLHEVLEEEATSKQPIPDAQLPSILDFIREFPVYLETIVQCARKTEIALWPYLFSMAGKPKDLFQMCLQSEQLDTAASYLIILQNLEPSVVSKQYATMLLDIALQQRKWELAKDLIRFLKAIDPNEIDSPRSSMVVNVKIAPPPQVNTQQQVNQNADAFNMVLGPIARERSFSTTVTSNLPKDKQASGTPGVAPVTESSSAGAPSVVRRRSTKQRETFCIDLILQRHARQLLQNHKLMDLGYMCAYLDFHLVSWLSQESERAAKLDDFAGALQALHEELDLPIPFPTAAKDDFAQIRGSLRQTGGGGSSQTSESGYFSLATPNGAATQSPQLQPSIREEEEELQQPSSLPILKTRSGSQLSFDNFRYRRLYSLPTSEDDLAVDILPQKLSIKLRYLLQLFIEANCTDYALVLSILLQDAASISRIVNGIIRSESVHTCRRTESALKQLSQSTFEHSGSLYRGFVLTLQPHVYLLEQYIQSLGDAPCSQLQDAGPGTEQGVDVSTGLQGLQNEVGEFVPNSQQANGNQWTVADLNPNHQRLTRHASLESNGNAVVASGSSAHSTPTQRQLSRQNSREREGCRLM
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin. Involved in the last step in mycaminose biosynthesis by mediating dimethylation of the hexose C-3' amino group.
Domain:
His-123 is a strong candicate for an active site that hydrogen bonds to a water molecule which in turn hydrogen bonds to the C-3' amino group. However, it is not conserved in related S.venezuelae DesVI methyltransferase and its mutagenesis does not completely abolish catalytic activity.
Sequence:
MAHSSATAGPQADYSGEIAELYDLVHQGKGKDYHREAADLAALVRRHSPKAASLLDVACGTGMHLRHLADSFGTVEGLELSADMLAIARRRNPDAVLHHGDMRDFSLGRRFSAVTCMFSSIGHLAGQAELDAALERFAAHVLPDGVVVVEPWWFPENFTPGYVAAGTVEAGGTTVTRVSHSSREGEATRIEVHYLVAGPDRGITHHEESHRITLFTREQYERAFTAAGLSVEFMPGGPSGRGLFTGLPGAKGETR
The following text describes a protein:
Function:
Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.
Subcellular Localization:
Endosome, multivesicular body membrane; Peripheral membrane protein. Prevacuolar compartment membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Sequence:
MSYMPSDDEVNTDVQSLQLQATGRGLVLSHNAHATSQVSDIDVECGTVASLKDPVLQRGVEDIEYMLTKSIHCDLFLEDDCQFSTGSHLKLLSQIEPPFADAERTHFIISPAGKPIFESHSEEESRYVISGALQAIVSSFDCWNEELHSFTSNEQRITVMKRDPLFFVCIETKARLSQRMITHELSFLYSHLSSILLAKSIEHAFTQRPGYDLQRALGNATVFLSAAAEDVHCFDPSSILTAVPCLPVPHSFRERLAALLLKTKSDELLFAMIAINGKIISAIRPKSYAWHPADVCLLLSAVYHTTAFKDSAEHWLPICLPHFCKTGYAYAYVHYLDDSISLVLTSTDPTAFFELQQMKMKMLKELNLEKEIYQKLHEYESLSSSLTCHVGFPVILHFAVYSKELSQLYFPGYVCEHVTQEARRLYAIYAELYDRSMDQQQPFLLLMDETTPIIKITWSTATMQFFCIANSISDRGLIFATMRRIYKWVKLKKKDIFLVESPTF
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Subcellular Localization:
Nucleus.
Sequence:
MSSTKIDLKFSDLADERSYFKKYSQLPPKESTTIRFIDHNNHDYFTALGSDADLIAEKIYRTQSVIKHHNQTKYVTISPQNFKESLNYCLQNHFKVEVYHSKTFQLISSGTAGNLDSLSEEFDIDFDFRDGSSSSIAAIKLGNKVGVCVIADSIVHLSEFEDNELYSNLESLLIQLGVKEVVIPANVDNKKFFQMLEKLNDLVVSAAKSFPKDNEQDISKLLDTENLELSLAAKGINSLDYALALSCCGALIDYLDLLNGDKTFEINKYNLSTFMKLDSSTMKALNILPNGTQKAITSIFELFKCKTLGGSRLLSQWLKQPLIDLSLIEERQELVKAMIDDTSLRVEIQEFLSKVPDINRLLKKIGLGVKRSGAENKKLNEVVNLYQLVSLLPNLTEILTIDYYAKPLKKDEQALSKFCELVETTIDLDTSFDKDYKIKPDFDPSLSEISNNMESAFKAINDLYLEAGDDLNLDTASNKLKLEQHQTHGWCMRVTRNDSRVLRGKSQYKELQTVKSGVFFTTIEMKRLSQEYTKAYDEYNVKQSEVIKEILSLTLTYEPVLQSLSSTLAHLDVITCFATTAMLNSYTQPKLFPFESSRKINLIESRHPLLEVQDDINFISNDVKMDDKHFAIITGPNMGGKSTYIRQIGTIALMAQVGSFIPANDGAELPIFDAILSRVGAGDSQLKGLSTFMIEMLETSSILATATANSLIIIDELGRGTSTYDGFGLAWAISEELIKRKCFAVFATHFHELSQLSEKYDGVENLNLMAEQTNEDITLIYKVGPGISNTSFGISVAEKLHMPEKIVNMAKRKVEELSEEPPIKKQCSETEVREGMSRLREILKEWRNNPEINIADSLAKEPNKFINYIVDTL