lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MKYFILTGQPHVELIADFEMKEPISSFSFFFSNEFSSHLGPFSCIFDNDKEKSIAYVLEQLLEEGNKKEFEVLLHDSDKGKIVCNFDIVGELHGIGVKSSINDPDLMQFRGIIMPQLYNQAKEVNTYIYLLKRDIVDIRCVVSPKIDLTQVHFHLISPSSKTEIPFQIQYFTNTTTIEVEQIIEHDYIKFTSNPHLVSLRKEIDFINISNLGTSLNEFNLNEVQASHNTVYDFFLHLPLSISSFHFYDSSGNISTSSYFCSSYTCTYNLIGRYPLLGNWKESFSISYEQLIPFNSTFIFPISLALESISVRNYEVHIHFPNGMKIKNVKCDVYNLCDHFKFTVPFLKYWTFDNIIFHYKNLDITSFHQMIWFEYALIKESHGYWIVACFFLISIFLLIFFIILIKLLERNEWRDWIYDKLINRKK
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVREKMLEILEGIDIRFKEPLHSYSYTKVGGEADYLVFPRNRFELARVVKFANQENIPWMVLGNASNIIVRDGGIRGFVILCDKLNNVSVDGYTIEAEAGANLIETTRIALRHSLTGFEFACGIPGSVGGAVFMNAGAYGGEIAHILQSCKVLTKDGEIETLSAKDLAFGYRHSAIQESGAVVLSVKFALAPGTHQVIKQEMDRLTHLRELKQPLEYPSCGSVFKRPVGHFAGQLISEAGLKGYRIGGVEVSEKHAGFMINVADGTAKDYEDLIQSVIEKVKEHSGITLEREVRILGESLSVAKMYAGGFTPCKR
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSLGVIAAAIAIGLSALGAGIGNGLIVSRTIEGVARQPELKGALQTIMFIGVALVEALPIIGVVIAFIVMNK
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSTSYSVTTYMTTTYVNCEDVSGSDSEYSEYDLVNEQMQDFLLDSEDTSDGDADVEDILGFGAVFMGGLMPTRSMDAHQACAWRRTTKPNRRRIAKKSESCSSLSNAARLTASSSTTMLSDLDTVVREAVVTGGAAQRRGTRKQRRAMASGERRWLVPPLSAVSVESTDGGNDGRRQLPWFTVVFDLDETLVGARYGPIHLRPHVGELLRSLHRLPVEIIVWTAGTAHYVNPILHAIGQACGRRQWFHHIISRHKRWYRDTNVSVKDLRQLGRPLDRLVMVENNPISALPQPSLCVLLEDYLQPNAADESLLVLKGLLERLALQYERAARTSSATGTCEQASEEECPAQRHTRSPRNTLRDATATRTTALPSLELLVRDDAALQLVEFRMEDILKEDGVPMLQQAEMRELVGGADTLRCLCLCYTPPLLPSSTAVAPQGTAALMSCVSMAMRSYGSVNPLRPL
The following text describes a protein:
Function:
Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures. Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (By similarity). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4. Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression. Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets.
Subcellular Localization:
Nucleus. Chromosome. Note=Detected on chromatin.
Domain:
The Bromo domains specifically recognize and bind acetylated histones; The NET domain recognizes and binds the 'KIKL' motif found in chromatin proteins.
Sequence:
MSTTAAAPTGIPAVPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQNAGSQQVAAVSSVSPATPFQNIPPTVSQTPVIAATPVPTITANVTSVPVPPPAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSEPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRHCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDSREYPDAQGFAADIRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPMEAPALPAPTAPIVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKDKDKEKEKHKAKSEEEKKAKAAPAAKQAQQKKAPTKKANSTTTASRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPLSTSGKKQAAKSKEELAQEKKKELEKRLQDVSGQLNSKKPTKKEKSGSAPSGGPSRLSSSSSSESASSSSSGSSSDSSDSE
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of Srp54 to the SRP complex (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MATAVPMKKNWSPSMKHNDMERWICIYPAYINRKKTRQEGRRLPKENCVDNPSYIEIRDVLSVSNLQFLMENKKYCRENSSEMEFRGRVRVQLRNVDGTLYNNDFPTRESIMLHIASKIPQLKTRQNKSGDSYHQQSQPQSNASGSGGGGGGKKGKGKRR
The following text describes a protein:
Function:
Involved in protein trafficking via association with clathrin and AP2 complex. Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling. May play a pivotal role in the formation and/or maintenance of lipid rafts.
Subcellular Localization:
Cell membrane; Lipid-anchor. Cytoplasm. Membrane raft. Endosome. Early endosome. Note=Translocates from cytoplasm to cell membrane where it colocalizes with poly (I:C) and then moves to endosomes where it colocalizes with TLR3. Translocates from cytoplasm to cell membrane where it colocalizes with TLR4 and then together with TLR4 moves to endosomes, upon lipopolysaccharide stimulation.
Sequence:
MGCGLNKLEKRDEKRPGNIYSTLKRPQVETKIDVSYEYRFLEFTTLSAAELPGSSAVRLASLRDLPAQLLELYQQGFSLAALHPFVQPTHEREKTPLEHIFRAILIKKTDRSQKTDLHNEGYILELDCCSSLDHPTDQKLIPEFIKKIQEAASQGLKFVGVIPQYHSSVNSAGSSAPVSTANSTEDARDAKNARGDHASLENEKPGTGDVCSAPAGRNQSPEPSSGPRGEVPLAKQPSSPSGEGDGGELSPQGVSKTLDGPESNPLEVHEEPLSGKMEIFTLFNKPKSHQKCRQYYPVTIPLHVSKNGQTVSGLDANWLEHMSDHFRKGGMLVNAVFYLGIVNDSLHGLTDGVFIFEAVSTEDSKTIQGYDAIVVEQWTVLEGVEVQTDYVPLLNSLAAYGWQLTCVLPTPVVKTTSEGSVSTKQIVFLQRPCLPQKIKKKESKFQWRFSREEMHNRQMRKSKGKLSARDKQQAEENEKNLEDQSSKAGDMGNCVSGQQQEGGVSEEMKGPVQEDKGEQLSPGGLLCGVGVEGEAVQNGPASHSRALVGICTGHSNPGEDARDGDAEEVRELGTVEEN
The following text describes a protein:
Function:
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Subcellular Localization:
Cytoplasm.
Sequence:
MHLKLKKQKIQESLSKIQNIVEKKSIMPVLNHFLMDVTENAVFILATDLETAVKQPLEAEVLEIGKACIPARKFYEIVKELDEDIEIMLLEQWIKIQSGRSNFRLASLDPSEFPVWPQIGDATQINLSRDFLLTAIEKTIYASGEADARYVLNGLLFQIKEPAEFNVVGTDGHRLAHFKATVEDISSIEGEKKVILSKKSLNELRKFLSDTETVSIHIGKTHVMCEIDGINFLTRMIEGNYPDYETVIPRHNDKIAIVDKNSLIASLKRVSVLSRERQNAVKTEWDKDLLIISSSDPEIGEARDELTVDYQGEPFIIGFNARYLIEALERITSDKAKITMSEPDKAVYITDGEAASFVYECVVMPLRL
The following text describes a protein:
Function:
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity).
Domain:
The caspase domain lacks the active site residues involved in catalysis.
Sequence:
MAQSPVSAEVIHQVEECLDEDEKEMMLFLCRDVTENLAAPNVRDLLDSLSERGQLSFATLAELLYRVRRFDLLKRILKTDKATVEDHLRRNPHLVSDYRVLLMEIGESLDQNDVSSLVFLTRDYTGRGKIAKDKSFLDLVIELEKLNLIASDQLNLLEKCLKNIHRIDLNTKIQKYTQSSQGARSNMNTLQASLPKLSIKYNSRLQNGRSKEPRFVEYRDSQRTLVKTSIQESGAFLPPHIREETYRMQSKPLGICLIIDCIGNDTKYLQETFTSLGYHIQLFLFPKSHDITQIVRRYASMAQHQDYDSFACVLVSLGGSQSMMGRDQVHSGFSLDHVKNMFTGDTCPSLRGKPKLFFIQNYESLGSQLEDSSLEVDGPSIKNVDSKPLQPRHCTTHPEADIFWSLCTADVSHLEKPSSSSSVYLQKLSQQLKQGRRRPLVDLHVELMDKVYAWNSGVSSKEKYSLSLQHTLRKKLILAPT
The following text describes a protein:
Function:
Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD51 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=DNA damage induces an increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA.
Sequence:
MRGKTFRFEMQRDLVSFPLSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLATACIQHLQLIAEKHKGEEHRKALEDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKIDRNQALLVPALGESWGHAATIRLIFHWDRKQRLATLYKSPSQKECTVLFQIKPQGFRDTVVTSACSLQTEGSLSTRKRSRDPEEEL
The following text describes a protein:
Function:
Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes. ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity.
Miscellaneous:
MISCELLANEOUS: Small amount of ATG5-ATG12 conjugate is enough to perform normal autophagy.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Note=Localizes to the isolation membrane (IM), a membrane sac which is generated from the pre-autophagosomal structure (PAS). Ultimately, the IM expands to become a mature autophagosome. Also localizes to a dot at the junction between the IM and the vacuolar membrane, termed the vacuole-IM contact site (VICS).
Sequence:
MSRILESENETESDESSIISTNNGTAMERSRNNQELRSSPHTVQNRLELFSRRLSQLGLASDISVDQQVEDSSSGTYEQEETIKTNAQTSKQKSHKDEKNIQKIQIKFQPIGSIGQLKPSVCKISMSQSFAMVILFLKRRLKMDHVYCYINNSFAPSPQQNIGELWMQFKTNDELIVSYCASVAFG
The following text describes a protein:
Function:
[Irisin]: Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA.
Subcellular Localization:
[Fibronectin type III domain-containing protein 5]: Cell membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein. Note=Imported into peroxisomes through the PEX5 receptor pathway; [Irisin]: Secreted. Note=Detected in plasma following endurance exercise.
Domain:
Fibronectin type-III domain is capable of forming a continuous intersubunit beta-sheet dimer; dimerization may thereby play a role in cell-cell adhesion or signaling.
Sequence:
MQAARGGAGRPGREGRGLERECERSPGPGVAMPPGPCAWPPRAALRLWLGCVCFALVQADSPSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQGQSPASEPVLFKTPREAEKMASKNKDEVTMKEMGRNQQLRTGEVLIIVVVLFMWAGVIALFCRQYDIIKDNEPNNNKEKTKSASETSTPEHQGGGLLRSKI
The following text describes a protein:
Function:
Small polypeptide acting as a regulatory molecule which coordinates cellular responses required for differentiation, growth and development, probably by restricting polar cell proliferation in lateral organs and coordinating socket cell recruitment and differentiation at trichome sites.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MCIILHSCTARLPQAQNLQIELKQDQVQASFKSNEKKNSIFIKLVSEKPMLINRRVESSNLLHSNMGGFLAKKTNSNSKIRNSFTSKCTSLMKQQHARLCIIRLCATMLLRSYTDHDDY
The following text describes a protein:
Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.
Sequence:
MRFVSRRLSFLSPPIIPLPKPAPTADAKPFFAPSSNEKGSAAFASPSTKHQTYVKKNATSSSGAATLESATAKATRSAQATGEPCTKFNGSSTNGTRRSGDNCAAEKVHHLPRFLSPDNIIKRVATPALFAASIVADTLNAPAALSGGSSAVNEEGGLQKYVEHCMLGWSPSELYNVVADVSQYSVFLPWCLDSTVHQVGPLGTTETASETANGNANVSGNDNGNGVAPATLEMLATLTVGFSFFREKYTSRVLLDPHKRVEAMLTEDEHKKRPAALRNLKCVWEFHEVPDSPRKVEVRFLVSFAFKNPMYSKLIMSHVVSIMTTSFEKHCEVLYGPPSCVRVHLPHN
The following text describes a protein:
Function:
Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MAINLNHEVLPPELINSVQELNSSIDKVDKILDQIITNQFADNIDKLELLDQAKAYLVVTYAMNSLYWTKNRYALLAMKVDKKAAGRIIKSALKQPIKKDEADNTKSSRKLEKVRKAAANKKRKIDHSTS
The following text describes a protein:
Function:
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Does not accept 4'-phosphopantothenoylcysteine as a substrate.
Sequence:
MVTVEESVVNTKLSPPNSYSAVVLGGTFDRLHDGHRLFLKAAAELAKDRIVIGVCDGPMLKNKQFAELIQPIEERMHNVENYIKSFKPELVVQTETITDPYGPSIVDENLGAIVVSKETVAGGLSVNKKRADRGLSQLKIEVVDLVPEESGGANKLSSTTLRRLESEKAKEQQTPTES
The following text describes a protein:
Function:
Part of the ABC transporter complex YtfQRT-YjfF involved in galactofuranose transport (Probable). Binds to both alpha- and beta-galactofuranose.
Subcellular Localization:
Periplasm.
Sequence:
MWKRLLIVSAVSAAMSSMALAAPLTVGFSQVGSESGWRAAETNVAKSEAEKRGITLKIADGQQKQENQIKAVRSFVAQGVDAIFIAPVVATGWEPVLKEAKDAEIPVFLLDRSIDVKDKSLYMTTVTADNILEGKLIGDWLVKEVNGKPCNVVELQGTVGASVAIDRKKGFAEAIKNAPNIKIIRSQSGDFTRSKGKEVMESFIKAENNGKNICMVYAHNDDMVIGAIQAIKEAGLKPGKDILTGSIDGVPDIYKAMMDGEANASVELTPNMAGPAFDALEKYKKDGTMPEKLTLTKSTLYLPDTAKEELEKKKNMGY
The following text describes a protein:
Function:
Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLDFLGYNFSPLGAAGSLSLLLALGFALVALVSGVLGGVRRDERLTGMARYALWGNFGFMTVATLLLQYAILTDDFSVRYVAQHSMTVSPLWVKWVTLWAALEGSILLWAWILSLYAFLVSLTARRDVLRPWVLATMALSVVFFVGLNLTVASPFTPVVDVPLQGRGPNPLLQNHWMMAVHPVLMYLGFVGLSVPFAYAVAAMITGRLGESWLVQTRRWTLVAWGFLSAAIVAGGWWSYEILGWGGYWAWDPVENASFIPWLLATAFLHSVQIQERRRMLKTWNIYLIVFAYAATVLGTFLTRSGVVESVHAFSNGPIGPVFLGFFVLLVALGVGLATWRLPQIRDPHSLDSPLSREGSMLGGNVVFVVFGLLVVLGTLFPVLVEEVRGIRTSVGEPFYNYFAIPLGLLLLLVMGVGPVLPWRKAGNGDLRSLWALTRWPVAAAVVGTVLAFALGVRNVGLALTLGLCAYNVVGLGQLVAGSARARGGLGALPGLVREYPRRYGAYVAHLGIVLIAIGIGFSGTYKARQEVTLRPNVPQTVLGKTLTLTNLGTEQRPERQSIVATVQAGSETLMPKLNTYVNMPQQVAMPAVKYHLMGDTYVTLLSGDVNQQWATVAVIDSPLVGWIWWGGLVLLLGTALSVTAPVRETVAVRAPARGLEGVTA
The following text describes a protein:
Function:
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Sequence:
MKYKTCVSIAEKTPNKVKQTLKIALKKSDFVEIRFDFLKIEQIPQTLELIKKDLKKSVCTLRPKTEGGQFPGNEKERIAIIKLIAEYNPYLLDVEFNTLKRNSSLVKYLKSTKTKLLVSWHDFKKTPSSAELKKKMNQMSKFSNFVKIVSTAKSTDDSTRMLELYSKKGKNNLISFAMGDFGRISRILCLYLGSPYTYVSLGKPVAPGQFSVDEVNKITNLKK
The following text describes a protein:
Function:
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.
Sequence:
MIEDDIYRTSSQYRLWSFTEETLRSVRQNTNRLASDRVRVALRRAREARQSANSSAAGTPNANASDVDSKTSEEKDIECLTPEEEQDLVRYYCEQIIQLGESYKPPLPTIVRATAIQYLRRFYLTNSPMTYHPKTIMPCALFIATKTDNYYMSLRHFADGVPGDTTAEDIIAPEFLVMQSLRFTFDVRHPFRGLEGGIMELNAIAQGLGQPAPHLPTQTAEDLRRAILSLPPSPNNPSTSSSSISDRLARAHHNTREILKSAAQMTDAYFLYTPSQIWLSALSIADQPLAQFYLDTKLPTPNASETGNEHPLAHLRAKVLQTLTSCATLLQSYKPLASDPEQKKAMRRIGKKLYHCQNPEKVNLAGQKRVPAAAAAVAASASANPSETATPDSEMERLAKKRKLEAEQQKARDIFGGELVMERTKERQA
The following text describes a protein:
Function:
Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
Subcellular Localization:
Secreted.
Sequence:
MTCRVCLLVFALGLQLATFGLRAEITQENTEAVFVSQQMAHTVLHRQRRYNTGHLEEFLQKDNLERECKEEVCTMEEAREVFENDEETLKFWASYIDGDQCDPPPCLNGGVCKDGMSSYVCWCQPNFRGKNCETEIKRCSIDNGGCMHLCVMQARRAVCYCAAGYKLGLDKASCEPTEEFSCGRVSRSSGSDTRSIQTQQTSNNTFTPRSVQNSSAPQEEDYYDDDKMQLSDYFDLLLNGSDTVNVSHKARVKVRSVKPDSGLSTEAEGVAEGTAETPLETEQDYSWGFPTMAPIKLKKVTQTRIVGGDVAYPGEIPWQVTLMTRPPSQKRAQPFCGGSLLSDLWVITAAHCLNNMGPDFFVRVGEHDVNVDEGPERDHAVAERHVHSSYDPRISDYNHDIALLKLASPVELSNQRRPICLGPKGFIETLVEEATSSLVSGWGKLRFYGPEATKLQKLAIPYVDRKVCKESSSDHITRFMFCAGFRDQQKDSCKGDSGGPHATNYKGTWFLTGIVSWGEECAKEGKYGIYTRVSHYYPWIVQKTGIRMTT
The following text describes a protein:
Function:
Golgi matrix protein playing a role in tethering of vesicles to Golgi membranes and in maintaining the overall structure of the Golgi apparatus. Functions in the anterograde transport of storage protein precursors from the endoplasmic reticulum (ER) to the Golgi complex.
Subcellular Localization:
Golgi apparatus. Golgi apparatus, Golgi stack. Note=Concentrates only on one side of the Golgi bodies.
Domain:
The C-terminal domain (689-914) is necessary and sufficient for Golgi targeting.
Sequence:
MDLASRYKGVVGMVFGDNQSSNEDSYIQRLLDRISNGTLPDDRRTAIVELQSVVAESNAAQLAFGAAGFPVIVGILKDQRDDLEMVRGALETLLGALTPIDHARAQKTEVQAALMNSDLLSREAENITLLLSLLEEEDFYVRYYTLQILTALLMNSQNRLQEAILTTPRGITRLMDMLMDREVIRNEALLLLTHLTREAEEIQKIVVFEGAFEKIFSIIKEEGGSDGDVVVQDCLELLNNLLRSSSSNQILLRETMGFEPIISILKLRGITYKFTQQKTVNLLSALETINMLIMGRADTEPGKDSNKLANRTVLVQKKLLDYLLMLGVESQWAPVAVRCMTFKCIGDLIDGHPKNRDILASKVLGEDRQVEPALNSILRIILQTSSIQEFVAADYVFKTFCEKNTEGQTMLASTLIPQPHPTSRDHLEDDVHMSFGSMLLRGLCSGEADGDLETCCRAASILSHVVKDNLRCKEKALKIVLESPMPSMGTPEPLFQRIVRYLAVASSMKSKEKSSTLGKSYIQQIILKLLVTWTVDCPTAVQCFLDSRHHLTFLLELVTDPAATVCIRGLASILLGECVIYNKSIENGKDAFSVVDAVGQKMGLTSYFSKFEEMQNSFIFSPSKKPPQGYKPLTRTPTPSEAEINEVDEVDEMVKGNEDHPMLLSLFDASFIGLVKSLEGNIRERIVDVYSRPKSEVAVVPADLEQKSGENEKDYINRLKAFIEKQCSEIQNLLARNAALAEDVASSGRNEQSQGSEQRASTVMDKVQMESIRRELQETSQRLETVKAEKAKIESEASSNKNMAAKLEFDLKSLSDAYNSLEQANYHLEQEVKSLKGGESPMQFPDIEAIKEEVRKEAQKESEDELNDLLVCLGQEESKVEKLSAKLIELGVDVDKLLEDIGDESEAQAESEED
The following text describes a protein:
Function:
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRREREMRGFYYIWDMSHVALQLHVVIALYALFRWGHGGIATINCSGNMWVEPGEIFQMGMNVSVYCQEALKNCRPRNLHFYKNGFKERFHITRINRTTARVWYKGFSEPHASMYCTAECPGRFQETLICGKDISSGYPPDAPSNMTCVIYEYSGNMTCTWNTGKPTYIDTKYTVHVKSLETEEQQQYLASNYVNISTDSLQGGRKYLVWVQAVNALGMENSQQLQVHLDDIVIPSPSIISRAETTNANVPKTIIYWKSKIMTGKVFCEMRYKATTNQTWNVKEFDTNYTYVQQSEFYLEPNSKYVFQVRCQGTGKRNWQPWSSPFVHQTPQTASQVTSKPPHEPQKIEMLTATIFKGHSTSDNSQDIGLLSGMVFLAILLPIFSLIGIFNRSLRIGIKRKVLLMIPKWLYEDIPNMENSNIAKLLQEKSVFENENASEQALYVDPILTEISEISPLEHKPTDYKKDRLTGFLETRDCPLTTLSTSSSVVYIPDLNTGYKPQVSNVPPEENHFINRDERDPMSLEATGDHFARLKTYPNFTFSASSMTSLSKTLILDELSLVLNQGEFNSLDIQNSRQEETSMILQNDSPSETIPVQTLLPDEFVSCLAIGSEDLPSINSYFPQNVLESHFSGIPLLQK
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTIADLWTIMPLLLLACGSVLVLILGAIVPGRYGTAIGVAVCAGAALWALQTPPRPLAPTLGVAFTPFARSFLVLFAVTALLSLLLAHDHADRQGLEGEEYPATILFGAFGMGVVASAANFLTLFLGLEALTFAFYILVAYDRNRPASGEAGLKYLLMGAVSAAFVAFGIALLYGATGSLEIGRAVAASAAGGGIALAGWGLLLAGLAFKVSLAPAHLWTPDVYQGGPTPVTAFLAAGSKGAAIALFLLILPPLGEIGPLRAPLWGLALLSMAVGNLAALLQPNVKRMLAYSSVAQMGYVALALLSGGRGYEAAAFYAVAYGVMSLAAFGALASLEQERPLEQVDELRGIGYRRPFQGVVLAVAMFALAGIPPTVGFAGKFAIFFAALRAGETPLAIIGILTAAASAYYYLRVVVNLYMKPAEEAAPGPLPTPAEAVCLGAVTVAILALGVWPGPLFDLVEAILKA