lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Subcellular Localization:
Chromosome, telomere. Cytoplasm. Nucleus.
Sequence:
MDPSPQSPPTKKRKMATSTSTSTAAPAVVEEHQFPLPPILTHPSAAPPTLITQGAEGRLYKTTFFSPDIPCALKYRPPKPYRHPVLDARLTKARLAFEAKVLERCRREGVPVPAVYAQNAAAGWIAVEWIEGAPVRVKINEWLGQRPKNEEEERSAAEQDQGPLIELMKRIGAAIAGLHRTGVVHGDLTTSNMMLRPHTNKTTSSEQTNGVSKEEEKAKLLEGDVVIIDFGLANQSQSDEDRATDLYVLERAFASTHPRAENLFEHLLESYKQSFKKGASVLHKLEDVRMRGRKRSMIG
The following text describes a protein:
Function:
Involved in the formation of peroxisomes, lipid bodies and protein bodies.
Miscellaneous:
MISCELLANEOUS: Travels from the cytosol to peroxisomes via the reticular and perinuclear endoplasmic reticulum (ER) and an ER-peroxisome intermediate compartment (ERPIC).
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Moves through an intermediate compartment from endoplasmic reticulum to pre-existing peroxisomes.
Domain:
The internal domain (235-279) containing two internal membrane helices and the intervening residues that include the basic cluster VRS is sufficient for targeting recombinant proteins to endoplasmic reticulum and then to peroxisomes.
Sequence:
MEAYKQWVWRNREYVQSFGSFANGLTWLLPEKFSASEIGPEAVTAFLGIFSTINEHIIENAPTPRGHVGSSGNDPSLSYPLLIAILKDLETVVEVAAEHFYGDKKWNYIILTEAMKAVIRLALFRNSGYKMLLQGGETPNEEKDSNQSESQNRAGNSGRNLGPHGLGNQNHHNPWNLEGRAMSALSSFGQNARTTTSSTPGWSRRIQHQQAVIEPPMIKERRRTMSELLTEKGVNGALFAIGEVLYITRPLIYVLFIRKYGVRSWIPWAISLSVDTLGMGLLANSKWWGEKSKQVHFSGPEKDELRRRKLIWALYLMRDPFFTKYTRQKLESSQKKLELIPLIGFLTEKIVELLEGAQSRYTYISGS
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MASEGENVVMESPGRRTRSGRKAASPAASLPTRSTRRTSKRNVQLSDHEEEAEEQVVMVQEEEEPFRGTNTAEAPALEPQFEETQHQIEDDVEMLPAEAAGVDEKSSSFPFGTVAELHSETSDDIKETRGQAGVDTLLASLAGDNANSLPSVGGNDESDNVKKADFEYNVDSLQPQMEKMNSSEDSSSQHAIAEDLADADTSNATIVNTEIVSEDELPLPSKPEINDAEEVSDEELPAPQRAELPEDAEVISEDELPASNNNNTATEPKAPLKRKAENESVKSTEDKDASSHESSTKDKSSEQYNPGSPTSESNDAQPSEKKLKVEESEPKEKKKEKERDKDKEKDKDKDNNKDKEKERKKLPDLDKYWRAVKEDSTDFTGWTYLLQYVDNESDAEAAREAYDTFLSHYPYCYGYWRKYADYEKRKGIKANCYKVFERGLEAIPLSVDLWIHYLMHVKSNHGDDETFVRSQYERAVKACGLEFRSDKLWDAYIRWENESKRYHRVVQIYDRLLAIPTQGYNGHFDNFQDLINQHDVTITLANEEVIRLRKDFHERQQSKSSKSSSKHRRDSSSSSKDKDSKEREREKDKDKDKDKDKEKRETVGGGVGKSPKDTSETQVDESDSTTDLTTESESSHAASKPAMQIDFSDLSTLNDEEVVSIRDRAISARRKVHKLTVSAVTARWSFEEGIKRPYFHVKPLERAQLKNWKDYLDFEIEKGDRERVLVLFERCLIACALYDEFWLKMLRYLESLEDQSGVVDLVRDVYRRACRIHHPDKPSLHLMWAAFEECQMNFDDAAEILQRIDQRCPNLLQLSYRRINVERRRGALDKCRELYKHYIESTKNKGIAGSLAIKYARFLNKICHDLDAGLAALQQALERDPANTRVALQMIDLCLQRPKVDEQEVVEIMDKFMARADIEPDQKVLFAQRKVEFLEDFGSTARGLQDAQRALQQALTKAKEAQKKSDGSPSRKNSSSSKEGPVPTGSAAAAYNNGGSAAAVAGYNYGAANPYYGQQNTAAAYPSQTPQQASYDSYYNQWGYGSGGASANSGGSGYNYGQWSGYGNYY
The following text describes a protein:
Function:
Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. NOT2 is required for the integrity of the complex. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Miscellaneous:
MISCELLANEOUS: Present with 2120 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEKFGLKALVPLLKLEDKELSSTYDHSMTLGADLSSMLYSLGIPRDSQDHRVLDTFQSPWAETSRSEVEPRFFTPESFTNIPGVLQSTVTPPCFNSIQNDQQRVALFQDETLFFLFYKHPGTVIQELTYLELRKRNWRYHKTLKAWLTKDPMMEPIVSADGLSERGSYVFFDPQRWEKCQRDFLLFYNAIM
The following text describes a protein:
Function:
Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex. Involved in the control of ciliogenesis and ciliary length.
Subcellular Localization:
Cell projection, kinocilium. Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MSSDKHSFLSQPVVKNVVMYRNGDPYFEGRRLVINEKRVSTFETFLKEVTGGVQAPFGAVRNIYTPKGGHRLTSLEHLQSGQQYVAAGREKFKKIDYLQIGAKKKKNLQNTAALIKPVAHSRIIVSARFLKPIKEPCAIFVVANGDVLNPAVRLLIPRRVLGQFDHVLEMITEKMGLRILGGVRSLYTLDGGLISDGKELENGQFYVAVGRERLKKLPYSELIFTKPVAMRRFIGSKAASLPPIFRFRKHNENGGEHQDKSAAGCSDTGDALTSPPARANKEQFSQGKGMKLRRKKNGLIMSLSSQDNEDGELKTWGDNREDLELEDDGLKTELPLEQAEAVNEEDSPKVESTEDLSNSGEDAAENLIEDSTTEQTNNNTDPANEEISTESEESQEVTEEPSHGEDDKEEEETRKEEENDTETEVTPAENGEDEEEENDEPQTKEELSKEESQNEEEVEENQKADEPEEQPEANTAEGEEAKQEEEPGPPHDDNGGMEEEEKKSLMESVDKLEGGNEEGEEKNDE
The following text describes a protein:
Function:
Sodium exporter that functions mainly at alkaline pH. Can also function as a potassium/proton and calcium/proton antiporter at alkaline pH. Does not play a major role in calcium export. The K(+)/H(+) antiporter activity may enable E.coli to adapt to K(+) salinity stress and to maintain K(+) homeostasis.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSNAQEAVKTRHKETSLIFPVLALVVLFLWGSSQTLPVVIAINLLALIGILSSAFSVVRHADVLAHRLGEPYGSLILSLSVVILEVSLISALMATGDAAPTLMRDTLYSIIMIVTGGLVGFSLLLGGRKFATQYMNLFGIKQYLIALFPLAIIVLVFPMALPAANFSTGQALLVALISAAMYGVFLLIQTKTHQSLFVYEHEDDSDDDDPHHGKPSAHSSLWHAIWLIIHLIAVIAVTKMNASSLETLLDSMNAPVAFTGFLVALLILSPEGLGALKAVLNNQVQRAMNLFFGSVLATISLTVPVVTLIAFMTGNELQFALGAPEMVVMVASLVLCHISFSTGRTNVLNGAAHLALFAAYLMTIFA
The following text describes a protein:
Function:
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
Miscellaneous:
MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEISKPRIVVLLVITAVTSMYAASKLVPGTPELDYWAYLHIIIAGALASAGSSALNHYYDKDIDPKMERTSKRPIPSGRMAASHVLIYGLAVSCISVIYGYFALNPVSAFFIAVGIFSYVIIYTAWLKRLNTSNIVIGGIAGSAAAWAGWSAATGSMDLLGFLVGFLVFVWTPSHFWCLAMKIKDEYAQAEVPMLPVVIGMQKTSKYILGNTIILLPYSLILSFIPDGMGVVYTIIAAVSGGLMLAYHYKLTKTPTSEFAWKAYKVTAPYLTIIFVAVALDAAFHIPLF
The following text describes a protein:
Function:
Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions.
Sequence:
MNNLNVIIADDHPIVLFGIRKSLEQIEWVNVVGEFEDSTALINNLSKLDANVLITDLSMPGDKYGDGITLIKYIKRHYPDLAIIVLTMNNNPAILSSVLDLDIDGIVLKQGAPADLPKALAALQKGKKFTPESVAKLLEKISANGYGDKRLSPKESEVLRLFAEGFLVTEIARKLNRSIKTISSQKKSAMLKLGVDNDIALLNYLSSVTISQVDKEL
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKLSETLKIDYFRVQLNAWRICGALDLSEGRYWSWSMLLCILVYLPTPMLLRGVYSFEDPVENNFSLSLTVTSLSNLMKFCMYVAQLTKMVEVQSLIGQLDARVSGESQSERHRNMTEHLLRMSKLFQITYAVVFIIAAVPFVFETELSLPMPMWFPFDWKNSMVAYIGALVFQEIGYVFQIMQCFAADSFPPLVLYLISEQCQLLILRISEIGYGYKTLEENEQDLVNCIRDQNALYRLLDVTKSLVSYPMMVQFMVIGINIAITLFVLIFYVETLYDRIYYLCFLLGITVQTYPLCYYGTMVQESFAELHYAVFCSNWVDQSASYRGHMLILAERTKRMQLLLAGNLVPIHLSTYVACWKGAYSFFTLMADRDGLGS
The following text describes a protein:
Function:
Acyl-carrier-protein synthase that transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of an acyl-carrier-protein. The 4'-phosphopantetheine (4'-PPT) portion of CoA provides the essential prosthetic group for a number of carrier proteins and multi-domain enzymes, priming them for the acceptance of acyl building blocks in fatty acid synthesis and many aspects of secondary metabolism mediated by polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs). PptA is able to transfer the cofactor to a broad range of enzymes with acyl- or peptidyl-carrier protein domains and activates target enzymes involved in the synthesis of lysine, but also secondary metabolites including gliotoxin, fumigaclavine C, fumiquinazole A, fumiquinazoline C, pyripyroprene A, fumagillin, the siderophores triacetylfusarinine C (TAFC) and ferricrocin (FC), and dihydroxy naphthalene (DHN)-melanin. Plays an essential role in virulence.
Sequence:
MGSAQNERIPSLTRWYIDTRQLTVTNPSLPLLEALQPSDQEAVKRFYHLRDRHMSLASNLLKYLFIHRSCCIPWNKISISRTPDPHRRPCFIPSPALTEATDEPIPGIEFNVSHQASLVALAGTIIPQSHGASPNPTTVFANPSPSSVPAPSVPQVGIDITCVDERHARTSSAPSTRDQLAGYVDIFAEVFSSRELDTIKNLGGRFPADAQDGEAVEYGLRLFYTYWALKEAYIKMTGEALLAPWLRELEFTDVIAPEPAPAPGQGSAENWGEPYTGVKIWLYGKRVEDVRIEVVAFETGYIFATAARGAGLGAESRPLSRDAGVAVSVDRWMHMEKIDIDRDIAPCATGVCQCTKKQP
The following text describes a protein:
Function:
Required for cell viability in cells lacking mitochondrial DNA.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MQSMQPSTVDKLKMGAIMGSAAGLGIGFLFGGVAVLRYGPGPRGFLRTLGQYMLTSAATFGFFMSIGSVIRNEDIPLIQQSGSHWNQRLLNENANSSRIFALAMQQAKSSPRKSNEVAEC
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MDPDFSRASRGPSFAFAFNSVNFSDRVLRIEIVAGDDAAGAKGAAGEGCSSLADWAHQRKRRREELRREKESGKYTDLETCKVEAEECDTYEENNEEPVAMIEESPPDIGQDGEDGDSCDSSWSMECTQVLRVKSIYISSAILAAESPFFYKLFSNGMKESDQRHATLRITASEENALMELLSFMYSGKLTTNQPTLLLDILMIADKFEVVSCMRHCSQLLRSLPMTTESALLYLDLPSSISMAAAVQPLTDTAKAFLANKYKDLTKLQDEAMNIPLAGIEAILWSNDLQVASEDAIYDFVIKWARSQYPKLEERREILGTRLLPLVRFCHMTCRKLRKVLACNDLDHEQATKCVTEALLYKADAPHRQRTLAADVLTCRKYAERAYKYRPLKVVEFDRPYPQCIAYLDLKREECSRLFPSGRIYSQAFHLAGQGFFLSAHCNMDQQSAFHCFGLFLGMQEKGSTSVTVDYEFAARTRPSGEFVSKYKGYYTFTGGKAVGYRNLFAIPWSSFMADDSLFFIEGVLHLRAELTIKQP
The following text describes a protein:
Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Sequence:
MVDPQPLVPTAEATDRLLDGVNALLAIGTFDTSDTALLGQMVASLADSRGMVRLGLVEAFGKIGLPAVPMLLEGLSRHSNPVVRRSCGKALAKTSDPRAVPVLIEALLHDEDTVVRSSAAGALAKMGEAAVPQLIALLTSEHSETAKGHAAWALAFMGTEVAEHLYTAYTHPAAAVRTAVVAAVANLTQETTDDRAVALLESALTDSAPGVRAEAAAALGTLAHQPAVPLLIEQLTDPSPEVRKTAALALAKIGDPTSLGPLEAQLARESGELQRVVAMALAQLQKRAMA
The following text describes a protein:
Function:
Glycosyltransferase that specifically catalyzes galactosylation of cytoplasmic tRNA(Tyr) modified with queuosine at position 34 (queuosine(34)). Galactosylates the cyclopentene hydroxyl group of queuosine(34) in tRNA(Tyr) to form galactosyl-queuosine(34). Mannosylation of queuosine(34) in tRNA(Tyr) is required to slow-down elongation at cognate codons UAC and suppress stop codon readthrough, thereby regulating protein translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MEVSENATTRGSLALVSIILPVHNAEQWLDECLMSVLQQDFEGAMELSVFNDASKDKSRAIIEKWKVKLEDSGISVVIGGHDSPSPRGVGYSKNQAVAQSTGSYLCFLDSDDVMMPQRVRMQYEAAGQHPTSIIGCQVRRDPPDSTERYTRWINHLTSDQLLTQVFTSHGPTVIMPTWFCSRAWFSHVGPFDEGGQGVPEDLLFFYEHLRKGGGVFRVDHSLLLYRYHLYAATHSVLEMTIWTHRVHFLEEQVLPHWKSFTIWNAGKQGRKLYRSLTAASRHKVVAFCDVDENKIRKGFYCYEDSQERPKPKVPILHFQAAQSPFVICVKLDLTGGEFEDNLKSLDLQEGRDFVHFS
The following text describes a protein:
Function:
Catalyzes the S-adenosyl-L-methionine-dependent formation of either N(1)-methyladenine or N(1)-methylguanine at position 9 (m1A9 or m1G9) in tRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MKTLADVFREALKEKGISSIGTLSKRFRKSKNKLQDIAIEIVHGKGAVFRVPEKTAVAWDLNGNRVDGSYYAYAPLCMREKFEPVLTPEELREKLPDWPYFIIDLYHWDKHTQKEKGKICLQVNQSYGLLRDYFTGSELAVTWANEEFREMFHGPLDRITTYGGPTSEFLKENGINEVVLLDPWAEEVLSEKDFDVKAFIIGGIVDTGGNKKKTTPKIGEELESAGIKVRRRKIVLRGDVVGVPDRINRILGIILKMMVEGKSMDEAVYEMQEPLHARWRLRKELPKRATRYMVEGKVYRVVEKELFDEYSKWLKIRWEDFVKVLRELDLVALERKRIHHLNKISNARIINGKLHRVILLKRAAMLCYNC
The following text describes a protein:
Function:
Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).
Sequence:
MKIENIRVFEGRNIYSHKKCIRMDVDLEGYSNISSKEIQEFNKTLLNYVPELREHCCCVGKKGGFVERLYEGTYLSHICEHVIIALQNRIGIDVSYGKAREIEGEKYYIIYQYKYKNMAIECGKIAVDLINNIINGKRYNIKTKTRELVCLLKTEELGPSTLSIIQEAKKRNIPVTKIGEDSMFQLGYGIKGKTIEATICNSTSAVSVDIACDKLLSKNILMDQCIPVAEGYKVKNYIDLLFKAEKLGYPVVLKPRFGNQGKGVVVNIKNQKELVNAYSIVNKKFQDIMIEKYINGKDYRACVVDGKVVAVAQRIPPYIIGNGKSTIYELIKELNRDERRGDGHEKPLTKVKIDKDLKNNINKEGYTLGYILPEEYKLELRHNANLSTGGVAIDCTDLICTETREVCERAAKAIGLNICGIDICCSDISKPLKENEGIMEVNAAPGIRMHQYPYKGKSRNVAKAIVDMMFKEYDGNIPIISITGTNGKTTTTRLIAHILSFSGKKVGMTTTGGIYINNKCINKGDTTGYYSAKTVLTNKEAEVAVLELARGGLIRDGLPYDLADVGIITNVTEDHLGLGGINTLEDMAYVKALVGEAIKKDGYVVINADDEASISIINRMKSKIILFTKNKNNPIISQYLDNKNLVLYLDEDTIYLKKLNKNEEIINVNKIPITLGGKLIYNVENAMAAIAALIALGIDVNTIRQGLESFSNEEQNPGRFNMYNVHGTNVILDYGHNIEGYKVVLESIKKIKHKRIIGVVGVPGDRTNSSTLKVGNICGENFDYVYIKEDRDKRGRKHGEIADLLKKGILETGFKNSKLNIILDEEEALKKAIEFSNPGDLVIMFFEEFEPAENIVKDKIKKGKITKRETALA
The following text describes a protein:
Function:
Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain.
Subcellular Localization:
[Isoform 1]: Mitochondrion. Cytoplasm, cytosol. Note=The 74-kDa cytosolic precursor is translocated into the mitochondria and processed via a 72-kDa intermediate to yield the mature 68 and 65-kDa subunits; [Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix. Note=Produced by the proteolytic processing of the 74-kDa cytosolic precursor; [Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix. Note=Produced by the proteolytic processing of the 74-kDa cytosolic precursor.
Domain:
The C-terminal ANK repeats prevent the assembly of the supra-tetrameric filaments; A highly mobile activation loop at the dimer-dimer interface is important for enzyme activity.
Sequence:
MMRLRGSAMLRELLLRPPAAVGGVLRRTQPLGTLCRRPRGGSRPAAGLVAAARLHPWWGGGGRAKGPGSGGLSSSPSEILQELGKGGTPPQQQQQQQQQPGASPPAAPGPKDSPGETDAFGNSEGKEMVAAGDNKVKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSIGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDDGKENQTVHKNLDGLL
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDKATETRREGAPTASKLNGQAMLGWVLHHIVWIWLIALVVIFGVFNEFFLTISNLQNVMVQATVLGTLGLAVALPLLVAEIDLSIPANAGFSAAVGAMAYAELGLPWPIAALIGLLVGTFIGFFNGVCITRLKMVSLIETLAMMIIIQGALLALTQGKTLTNLSEGYIWIGQATIGGWPLMPVVFLLVLAVMGAVLKYTVLGRSIYAVGGNPVASNSAGIRVARVKIIAYTISGFLAALAGFLLASWQMAITSNQGSSYLLYAIAAPIIGGVSVFGGHGNVKGVLGGVLLLTVIQVGLAIVNVPSFYVGMIGGVIIFIAVAIDAFRIRYFG
The following text describes a protein:
Function:
Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).
Subcellular Localization:
Cell outer membrane; Lipid-anchor; Periplasmic side.
Sequence:
MAMNHHQRRSVPRLLTPIALSIVLSACSTQPSSPDVVDITAQPLLTAQTYLMRADASQGNQQNDWLIMALKAAIEENNPDQAQLLIMRLAKQPLTPTQQAQWQLLRAQLLANTEQYQEALEQLSFQANWSLPQVQWQQYHQLRADIFTALDRSFDSTRELVALYGLSSNKDKEALADQIWANLNHYSASKIIKLSTEPDEAQLDGWLQLAIYMKTLGSDLPQLKNTLEKWLAENPQHPAAIYTPKAITDILALEIVKPTNTALLLPLTGKFAKQAQFIRDGFVFAMMNDADRQTNATLTIIDTNAETLESVDAILTSKQIDFVVGPLIKGNIEKLQQFQQSRGQMIPTLALNIPDQIDTTAGACYLALSPEQEVAQAAKHLFTQGYRYPLILAPQNAYGERVVEAFNEEWRRYSKNKVAVNLFGDKRQLQRNINSIFGLQDSQQNIAQMESLLGMGLESQPRSRRDIDAVYIVANSSELTLIKPFIEVAINPDTRPPKLFSNSNSNTGGRQYEDLSGVTYSDIPLLIQPAPSIKEQLTQIWPESSNAERRLQALGMDAYRLMVELPQMKIVEGYTIDGQTGVLSIDEQCVVQREISWAEHGVR
The following text describes a protein:
Function:
Required for normal Golgi function and necessary during spermatogenesis. Required for cleavage furrow ingression during cytokinesis in dividing spermatocytes and for the extensive polarized cell growth that accompanies spermatid elongation.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein. Note=Localized to Golgi membrane throughout spermatogenesis, as seen in spermatocytes and differentiating spermatids.
Sequence:
MVTGDPVATKTPNAADSDDNDFTASMSHLTIGQQIQELSKQLQNTKEELHQQVRDKHGALLQQATHAGRFDAALNALAEDVQRVRETGHRLKNQVDTQYQQVENQTQVLGRLHDVSHLLRSAGTLLSLTAKLKATKDVLRLAEIHFELGQLIEDKELKDIDFIQQERAYVISSAQKIRNLTQMQLVTGLQERNENQVVNALKIFMNFNTLEKSLDNLLATFIADMEQSLKECFAGNDISVLNKSPTHNVSKPAPSRGPGKTPQLTTTQNFRAKFWKSLHWLLYDELFETCTQIKLLKTALEQINQFGYTSESSDQCIPQRFWQQVQQLLRKSFDECPQHVTQTLQEGLSKLLTSARGLEQRLHGEFQFDNELFAPLEVGYVSKCAANFKACLAGVDLPGNETVDNFIRVASTELSAALIDSRLTNAIANVFAACGKELCTKLEAQIKLGADSKQVVDLPNLQQQQNTQLANVLFYYKDSVRRMLSDLHVHFEKTPGTAREIISRSLEQADLLIGTILQQIMESIITTISIIVLSMHREPGLNSERMSTTGPSMYMKELQEFVNRSWSHHIALFDDKQMTKKCGHELAKRCIELFLHNVCILRPLSSCGRQRLKQDCQHMEQALKPLCPNLAELGKPSRLLRAMSLLIVQTAEELVKQTIGEDSLVPSYIVLLLLFGHAGADLQSPHTTANWSNERLIEWLDGHTAEREKLELISGALQRYRDNARRKNIQQYDEVYPMMVDYFEQALKALP
The following text describes a protein:
Function:
Serine protease which ensures proper pharyngeal pumping during larval growth by regulating the levels of extracellular matrix component fbl-1. Independently of its enzymatic activity and probably by acting as a ligand for tyrosine-protein kinase receptor svh-2, involved in axon regeneration after injury by promoting the generation of productive and stable growth cones. May play a role in gonad development.
Subcellular Localization:
Secreted.
Domain:
The Kringle domain is dispensable for larval growth and axon regeneration after injury; The PAN domain is required to maintain gonad structure and thus fertility. Dispensable for larval growth.
Sequence:
MYIVIVTMRTILFFGIFFIFIFQCAKCIELKIFEDLLEVRSQSGLFFPLCSKSFHQKYGEQACASISSTFLSYSTVSLQQYTYSVGCTTSVCFTFLSSFCKTGVKVFCSPSLCASGTLQIGSKCLSISTVPVQGYSEANYYCNPATLISSLKPTEIESIRDTILPTFADTRLFLTSGLRQGATWKWGNGDTVEQEVTGTGRCLALQAGNLVAIDCDSEAYVFCESGRECIARDKEYSGTANRTSDGKMCLMWNDPTVLFRRERDLEILNHNFCRFVNDADGKKSATPVCYTKPNELSQCYIPPCPESFNDVVPIESGDSCPIGSISCDNGSKCISEKFQCDYEVDCNDGSDEHNCEDYLQYYELIGAYRLADNIIEVWTFIPHVQGCARKCRESLLMCEAFSYEPKSQTCLLTDTSQTFSSLARKITSLYYRRRFSTKDVEFQVENKVLYATKSAKKGHVCDDNYSREKLSSICRVLGFGDPIYTVESHQSESSLGPLQPTTLHPTNPSFDSPSSVSQMRRTSPSATLAPRLPAWNLSCLREPNCTSTVISTCEPIRCSHCQQAACGDGSCIRFDQLCNGQIDCQSGEDEDYCRANSFRLTNGSDTSGYLEVLFRSRWEPICADHLNGKISNSICDAMRLGEHGFILSTNATISSGYNVNCDVDCSIRRSSSCTRHARISCISQNGMSSASQCGLRYVEVNARDAAKSRIARVVGGFETVPGAFPWTAALRNKATKAHHCGASILDKTHLITAAHCFEEDERVSSYEVVVGDWDNNQTDGNEQIFYLQRIHFYPLYKDIFSHDIAILEIPYPGIEFNEYAQPICLPSKDFVYTPGRQCVVSGWGSMGLRYAERLQAALIPIINRFDCVNSSQIYSSMSRSAFCAGYLEGGIDSCQGDSGGPFACRREDGAFVLAGVISWGDGCAQKKQPGIYTMVAPYLSWISAIINGQPV
The following text describes a protein:
Function:
Involved in ATP-dependent DNA-unwinding in a 3' to 5' direction, and ATP-ase activities stimulated by the single-stranded DNA-binding protein ssb1. Essential for viability and normal growth of stationary phase cells and in the absence of either srs2 or rqh1 DNA helicase. Involved in DNA recombination repair of strand breaks and stalled or collapsed replication forks, on the rhp51-dependent pathway: promotes rhp51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Ubiquitination and DNA helicase activities are essential for controlling rhp51-dependent recombination in the absence of rad22. Plays a role in the processing of toxic recombination intermediates. Promotes proper chromosome segregation.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Becomes localized at discrete nuclear foci together with rhp51, in response to DNA strand breakage.
Sequence:
MSAQHLHSCKFYRLPLEIIPLICRFLSVQDIQSFIRVFPSFQTILDSSNDLFWKKKNYELRIRRNRLLRGSYAAGVSSSAMNGFVNGTQISSTPAEREYYSKSDEIKNICGLPPGPMKVEQIGHAIDHLVSETHTVDHLGSSIKASFFHIDDVPLEWISSICMQVQSFFSPAAREAISSLKSRTTTSNLLLSLFVGILFEDDLWYFFNTLYMLSSTSAIEFAYFLDSIFTVVRTDYEHYRDPLSQTLITSCTRIHNIVAVIESPYDEPNTKGLTSEQKMIVECQLNPGEVLKVKAFAGTGKTKALLEFAKSRPKDKILYVAFNKAAKEDAELRFPFNVKCSTMHGLAYGAILAQADLPQAKLERQLSNSTIASLLSLQVAFPKANRKNNPGTPSASLVASHIMFTLNRFMHSTDWQLGFRHISKRSLEVTKLSKEKLLAYTKKLWSLIVNFEYTHAPLIPDAYMKLLHLYEFPNIFSKYDYILFDEAQDFTPCMVDLIYRQKHARIVIVGDAHQCIYGFRGANACAFNENLYPSTKQLCLTKSFRFGNSVAKYANFLLSLKGENVKLKGVQNDHAYWSSASNPNNVSGAFRFFPHTIIFRTNKELILQSIRLSVSLPKEIPIAILGSMRKKAFQLLRSGSELAHGQRPSHPKLKDFSSWGEFEVHVKNSAEEDAELALVYDMADELFSESFLSRLDNCEKRLMDSKDDGDNGIILATAHQSKGLEWDNVQLGNDFRPKFDSVSFSRIGSSRYLQEEINILYVALTRAKKRLILNDTITKLYALECGLVRFAGGILTEDQLQPGKVALFVDWQIDKFSFFYETPAEGYNLLVEANEKSVWDIFFGVLSGAWQNYIANTSERLKRSMLFIENQLFAVHDQ
The following text describes a protein:
Function:
Mg(2+)-activated ribonuclease which hydrolyzes RNA apparently nonspecifically into oligonucleotides with 5'-terminal phosphate.
Subcellular Localization:
Secreted.
Sequence:
MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSGTGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKETDEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLRPADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEGDDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPFIDHPEWADEIWP
The following text describes a protein:
Function:
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
Subcellular Localization:
Cytoplasm.
Sequence:
MQMFCYQCSQTANGTGCTEYGVCGKSPTVARLQDNLVFAIKGISAYYYHARELGYDDPEIAGFLDEALYSTLTNVNFDAQSFVEYALEAGRMNLKAMQLLKKAHIETYGEPTPVEVETGTKKGKGIIVTGHNLKALEELLKQVEGTNVYVYTHSEMLPAHGYPGLRKYKNLIGNLGKAWYDQRKLFAEYPVAILGTSNCVLIPSESYRDRMFTTSIARLPGVKHIDGYDYTEVIEKAKSLPDLEEKPGSYKLRTGFSTSVVVSLADKIKELVEAGKIKHFLVVGGCDVPFKRNEYYREFVQKLPKETVVITLACGKFRINDLDLGDIDGIPRLIDVGQCNDTIVAIEIAQALAKVFGVEVTELPLTLVLTWMEQKAVAILWTLLALGLKNIYVGPVLPAWVNEDILKVLTAEFGLKTISEPEKDIKEILKV
The following text describes a protein:
Function:
Putative pheromone receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSLYDTVLGIIFLSQTGVGVLGNSSFLCFYAHTLFSSPRSRLLDPILVQLTLTNTIVLLSKGCPLVNIYFGNIYFLGSLGCQMVFYFQRMSRGLAVCTTCLLSIFQAVTISPSSSRLAKHKVRVLKLIRPSCLLCWIFNMIIEVNVPFHITGSKRINSSHTGGFEVLYCYWEKVLKEIIILPSLRDILCVGGMVWASGYIIVLLYKHQRKVQHIHRTSRSQKTSPEIRATQTVLLLLSIFVSAYCISCSFALYKVYDIHSGDWLVVMSTFTALCFPTTSPFLLIHRDSQIFRSCCASWQKPSLHS