lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the volatile terpenes biosynthesis pathways. Sesquiterpene synthase that converts farnesyl diphosphate to (E)-beta-caryophyllene. Involved in indirect defense by producing volatile signals that attract natural enemies of leaf herbivores such as Chilo partellus and root herbivores like the western corn rootworm (WCR, Diabrotica virgifera) and fall armyworm (Spodoptera littoralis and Spodoptera frugiperda). Deters leaf herbivores by triggering (E)-beta-caryophyllene production upon insect (stemborer C.partellus) egg deposition; (E)-beta-caryophyllene attracts the parasitic wasp Cotesia sesamiae which lays eggs on the larvae of C.partellus, which is ultimately fatal.
Miscellaneous:
MISCELLANEOUS: More abundant in insect resistant cultivars (e.g. cv. Mp708) than in insect sensitive cultivars (e.g. cv. Tx601).
Subcellular Localization:
Cytoplasm.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MAADEARSVSRLHSEEDMHGKHHSTLWGDFFLHHVPCRPGQYLIMKDNVEIMKEEVKKMLLDVGSSDLSHKLDCIDTLERLGLDYHYTKEIDELMCNVFEARDQDLDLTTTSQLFYLLRKHGYHISSDVFLKFRDDKGDIVTNDARCLLRMYEAAHVRVNGEEILDNILIHTKRQLQCIVDDLEPTLQEEVRYALETPLFRRLNRVQARQFISTYEKSTTRINMLLEFSKLDFNILLTLYCEELKDLTLWWKEFQAQANTTIYARDRMVEMHFWMMGVFFEPQYSYSRKMLTQLFMIVSVLDDLYDSHCTTEEGNAFTAALQRWDEEGVEQCPTYLRTLYTNIRATIKAIEEDLNFQNNKHAKLVKGLIIDMAMCYNAETEWRDKKYVPATVDEHLKISARSSGCMHLVSQGFISMGDVATSEALEWASTYPKIVRAVCIIARLANDIMSYKREASNNTMVSTVQTCAKEYGTTTVEQAIEKIRELIEEAWMDITHECLRQPQPKALLERAVNLARTMDFLYKDADGYTDSRSIKGILDSLYVHLID
The following text describes a protein:
Function:
Involved in the negative regulation of the Egfr/Ras signaling pathway. During wing morphogenesis, may function redundantly with PVRAP to inhibit Egfr activity and prevent uncontrolled cell growth.
Sequence:
MIMQDIRLRLEPQHSKATFISSSSASSSSSQTAETTLIETAEKSPASEAAAGTVTTTSPQHFFHHHHPPAHPHPPRQQPHPHSHSHPHPHPQLQRRPVEQLHLLHSHHDVQELSGQEHPHPQPGSHPHPHHLRSPSSEEDNSPTEMNNCRRLVDKPPLVKRLTMGIGLLRGTEDSRPLMHSTCGSSLTSGSGCGSTQTISDGYVNEAICEPDKYVASKFGDSCRQSLSALESATQRLQVELPAASKKYLRETCSANSSPKLFPGHSALRLDNLSLAEQQELKGAAWFQAGIPREISLEALSRQSPGAFLVRQSSTKPGCFALSLRVPPPSPRVAHYLILRTQRGYKIKGFTKEFSSLKALITHHSVMPELLPVPLTLPRPPSTRSQRSQGAYAGGTGNGGADFEMYGSLNDFRKMMADLNV
The following text describes a protein:
Function:
Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.
Subcellular Localization:
Nucleus.
Sequence:
MSLNLTANAIPAIIGGDVNAKPLVQVLDVALVSNSNNSQQQQQRYRLLLSDAVFSHHAMLATQLNDRVRTGRVQKGSVVQLLDYICTPLKNRKIIVILNMETIMDEFEIIGNPKPYMDSDIPTVRASDSASADSTVENLPRSYNSNNSSAGQNASHNNTQNFRPTIQPPYQPPPLYKGRGPVVKNEAPARIIPIAALNPYQGRWAIKARVTAKGDLRRYNNARGDGKVFSFDLLDSDGGEIRVTCFNAVVDRFYNVIEVGKVYMISKGSLKPAQKNFNHLKNEWEILLESSSMVELCPDEDGSIPRQQFSFRPISDIENVDNNSILDVIGVVTSVNPSVPILRKNGMETQRRILSLKDSSGSSVELTLWGEFCNREGQQLQDMVDAGFFPILAVKTGKVNDFSGKSIGSISTTQLFINPDFPEAHSLREWFELVGKDSASLSISKDIIPGALKNEVRKTVSQIKDEGLGRSDKPDWITVRAAILFIKTDTFCYTACPLMIGDRQCNKKVTRLGNTRWQCDRCNQEFEECDYRYLLQVQILDGTGLAWVTAFQEAGEEIMDYSAKDLYFLKHEEQDDEKFGEIIKSRLFNQFMFRLKIKEELYGDEQKVKITVVKADKVNYSSESRYMLDTISKFCRQ
The following text describes a protein:
Function:
This major extracellular protein may be involved in the invasion of non-professional phagocytic cells by Listeria.
Subcellular Localization:
Cell surface. Secreted.
Domain:
LysM domains are thought to be involved in peptidoglycan binding.
Sequence:
MNMKKATIAATAGIAVTAFAAPTIASASTVVVEAGDTLWGIAQSKGTTVDAIKKANNLTTDKIVPGQKLQVNNEVAAAEKTEKSVSATWLNVRSGAGVDNSIITSIKGGTKVTVETTESNGWHKITYNDGKTGFVNGKYLTDKAVSTPVAPTQEVKKETTTQQAAPAAETKTEVKQTTQATTPAPKVAETKETPVVDQNATTHAVKSGDTIWALSVKYGVSVQDIMSWNNLSSSSIYVGQKLAIKQTANTATPKAEVKTEAPAAEKQAAPVVKENTNTNTATTEKKETATQQQTAPKAPTEAAKPAPAPSTNTNANKTNTNTNTNTNTNNTNTNTPSKNTNTNSNTNTNTNSNTNANQGSSNNNSNSSASAIIAEAQKHLGKAYSWGGNGPTTFDCSGYTKYVFAKAGISLPRTSGAQYASTTRISESQAKPGDLVFFDYGSGISHVGIYVGNGQMINAQDNGVKYDNIHGSGWGKYLVGFGRV
The following text describes a protein:
Function:
Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MSIITRVGHIVLTKSIGNSITYSKSAVLPLSRLSSSLTATSQNEIKEHEPSNENPADVLEAKRNKSKLKSRHYKMLHGQMGVDPQNPLFPREETVRYRRKLIARHGLETGINLGIAWPTREELENQLEYDRVAHPFTIQEMVEKKKKLREEEANRIAERQKEINLKMGKLGSWMKELKDKNQKKESTARVAQEKKDALIEEVRQHFGYVVSVKDPKFQEMMVQKEKEAKKAEKDIKKKVRIERNAIKSIAFAEQISAEKETKSE
The following text describes a protein:
Function:
May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).
Sequence:
MSSKTQLRQQFCELTGTSNTTATKYLESVRYDLARAIDNYYNKHPNKAQVTKKPVKVKIDDRLIQIFDKYKDSEDPNKIDIEGTLTYLGDLGISPDQIESLSLALLLKSPKTGVFTRENFLHIWQYYQCFDIGAMSEFITRFNKDLVNNIGGFKDISTVSDDENKSVPLKFQDLYNFTFKFSLETESQKFLDLDTAIEYWKLLLPIITETYSKDNKLDEEFKNHVNERVEQWFKFLTDTEYMTKKSISYDSWSMFYLFFKEIVLIDPIKFKDYDEMAAWPSVVDEFLEYLHDFELL
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MGQQGCAHEENDLLVEELLALKQRVRESSHLASNYARAIASVRAHAEPLRSAAEAKKLRHIGNYLANQIHGILRKRGLLQQEADEITSVIAPSATAVARVQPEKSTRNAPLGTTRAYVPNYKKQPWFVLLALQDAHAVDEDTAVASDALLKRMQDAGYEGNSGKLRTCLASLSGTHEVVRRSNLGYYFLAEKGRRSAELCPGSLSDGATATATSSRPSATSGKGVARQRPSSPDWTCAELEASDDDVVCERVHEPEPEVVGRAPEVVGRAPEDLIRDTDTWELVLLLDHREVIERRNPRILERKLLERNVNCEVRALGVGDVQWIGRRHRIGGETQEFMMNVIVERKEVHDLSGSIIDRRFFEQKTRLATVREQCGDVRVIYLIEGSLTQITAVRTGGLHTAMGRTQVQNNFFVQQCQNADETVAFLARVYARLLAIFPSNPRVAKPASSHFLAQSKFDSIAFARTFCLPLQTFGPFNSQFRKKTQFTVREIFQRMLMQAPGLSAAKTVGLSAKYQNFRELESALRKRGRDSEVEHVRCGKTQRRLGAKARESLGELLIASEYTEDS
The following text describes a protein:
Function:
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Sequence:
MATFRLGAIASIATRIPHQNVAKLQRINLVRRMATGAAPKKPTSTLGLAVKGMAIGALVGTGWSGYSYFKGGPTDHMLHEHVGPKVLDKLPDVKIMRKVVNPNDDSGLDLVLFQFQTCPFCCKVRAFLDHSGLSYSVVEVDAVLRQDIRWSDSKKVPILLAKTKSGKYVQLTDSSMIVSSISSFLRDKKQDIGELAKYYPSISYENDAGRKVFDIMNKYFLMYQEKKVDNRTKEEQEEERKWRAWADDHLVHLISPNVYRTKDEAMETFEWFSDVGEWGIHFPKWERDLMVYVGAFAMWGISKRLKRRHQLSDDVRSHIYDACDRWISEIEKKKTTFHGGSQPNLADLAVFGVLNSMEGCQAFKDCLENTKIGPWFYAVKERVLKNRGNVL
The following text describes a protein:
Function:
Mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
MSVYLAEFLGTMLLIILGDGVVANVVLKKSKGHNSGWIVITTGWGLAVAMSVYLVGRISGAHINPAVTIGLAFIGQFPWSKVPGYIFSQILGAFVGAILVYLTYLPHWKETDDPDAKLAVFCTGPAVRKYGANLLTEIIGTMVLLMGVLGIGANKLADGLNPLLVGFLVWSIGLSLGGPTGYAINPARDFGPRLAHAILPIPGKRDSDWSYSWVPIIGPIIGGILGASLYNWLF
The following text describes a protein:
Function:
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity). Has a role in growth and sporulation on acetate.
Subcellular Localization:
Cell membrane. Membrane raft. Note=Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion.
Sequence:
MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNAAYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRVFIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERIPVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGSTGTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATNVIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGEPLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVDNQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYFWFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREGFEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGDLSTMED
The following text describes a protein:
Function:
Essential for biosynthesis of the polyamines spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Sequence:
MSATSATNFAVQTHPVKAPDEEYFFEGAEKLLELWFCSSTQNETRSLRIIPREEIDAMLDIARCKILHSKHNESIDSYVLSESSLFISDNRVILKTCGTTRLLAALPVIMQLAGAYAGLDQVQSVYYSRKNFLRPDLQPSLHKNFDAEVEYLDSFFVDGHAYCLGSLKQDRWYLYTFHREVEFPAHKQPDHTLEILMSDLDEEVLHKFTKDYAVDGNDCFMRAGIDKIIPAGADVHDELFDPCGYSMNAYMNDTDQYATIHVTPEKAFSFASFETNQDLVCLYSQTRKVLQCFRPNKILMTVFANDISEKGKDAQQQLWDRELPGYRRTNVQFVRLETETLVYAHFVRKASTGQDSSSSDEDDGERSD
The following text describes a protein:
Function:
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MNSFFPSRKLGQNFTVNLSVIKRIFAFVKNLNPQAIVEIGVGKGALTNYLLKLKIPYKGIEIDKRLIEYLLVEKILTEDQLVKGDILKKDFNSFFENLSPLLCGNIPYSITSPIINKFLESKLRSFVLMTQKEFANRLLAKVNSSDYSAFGAFCQYYLTITTVFKIDRHAFKPKPKVDSTLILLEKNKSVSYDFKFGLFLKQCFNQRRKMLINNLKHFFAVDYLLNIIQKQNLKTSIRAQELSPCQLFNLYQNICNGKN
The following text describes a protein:
Function:
Probably by regulating inositol 1,4,5-trisphosphate levels, negatively regulates posterior body wall muscle contractions required for defecation and let-23 signaling pathway that controls spermathecal dilation and ovulation. May also regulate ovulation downstream of actin cross-linker fln-1.
Sequence:
MHTQPQSYQAPEQTHMRIENRRIEAGKGGTNLLLIIESRVDTLSINLPTLYSLLFTTNITILMSAPQHRQLRRAAHITKIASIDLCSLEEEDHEDLVLEESGHHPSDIQNEKPNRPPYSTLIRKRSGKVFRFVRPKLADLWHSRYHEASFDLGRRLGIGRRTQSCCEDVCDEEVSVETMAITALPMDVWLKERLKKWVQLSGHEGSIVPATPHTLYKKQCANCGEGRAYKNISKDPALDGFTPKYYDELEKNEEHFIEIEDLLQQFHDPTKTAIMDIKIGTRTFLESEVSNTKKRADLYEKMVAIDNDEPTEEERKCGAITKLRYMQFRERESSTAQLGFRIEAAKRLEGALEKNFKKVRTVEDVTTTFMDFFGTQRSRVRQQLIERLKSMRKAIEHSSFFNSHEVVGSSILIVFDTEKVGCWMIDFAKSSPVPNGRTLNHRTTWIPGNNEDGYLIGIDNLVKILEELPEYGEHPDDQLMVTEEVIARMKNTKS
The following text describes a protein:
Function:
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP.
Subcellular Localization:
Cytoplasm. Nucleus, nuclear body. Nucleus, nucleoplasm.
Sequence:
MAAPMSSETDRQQLGFSANSEQRSPGFWRSHVYKEVEITTVDGRKHRGWVYTVDPVSESVVLVQFEEDRKKTVEMVMGHAMKGITVVNEDIDSHKEELDHMFITADDTSFSKQDLETRRDELKQWLEKNRLPVKVSGKEGELLSISDALVIEPPYSAESCRSTNEIILGRIQALIRSKPTSGQ
The following text describes a protein:
Function:
Plays an essential role in tail assembly by capping the rapidly polymerizing tail once it has reached its requisite length and serving as the interaction surface for the completion protein.
Subcellular Localization:
Virion. Host cytoplasm.
Sequence:
MKHTELRAAVLDALEKHDTGATFFDGRPAVFDEADFPAVAVYLTGAEYTGEELDSDTWQAELHIEVFLPAQVPDSELDAWMESRIYPVMSDIPALSDLITSMVASGYDYRRDDDAGLWSSADLTYVITYEM
The following text describes a protein:
Function:
Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis; Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.
Miscellaneous:
MISCELLANEOUS: Four consecutive Gly-Pro-Pro triplets are present at the C-terminus of the triple-helical region. These may provide the high thermal stability of this region.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MAVLPGPLQLLGVLLTISLSSIRLIQAGAYYGIKPLPPQIPPQMPPQIPQYQPLGQQVPHMPLAKDGLAMGKEMPHLQYGKEYPHLPQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGPPGPPGLPGHGIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPHAYGAKKGKNGGPAYEMPAFTAELTAPFPPVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNNEPVMYTYDEYKKGFLDQASGSAVLLLRPGDRVFLQMPSEQAAGLYAGQYVHSSFSGYLLYPM
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Sequence:
MFTLRELPFAKDSMGDFLSPVAFDFHHGKHHQTYVNNLNNLIKGTDFEKSSLFAILTKSSGGVFNNAAQIYNHDFYWDCLSPKATALSDELKGALEKDFGSLEKFKEDFIKSATTLFGSGWNWAAYNLDTQKIEIIQTSNAQTPVTDKKVPLLVVDVWEHAYYIDHKNVRPVYLEKFYGHINWHFVSQCYEWAKKEGLGSVDYYINELVHKKA
The following text describes a protein:
Function:
Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.
Subcellular Localization:
Nucleus.
Sequence:
MTESPEDLNFPNAVVTRIIKEALLDGVNISKEPRSAISRAASVFMLSATYWANNFAMKGKRKPLNASDVLSAMEEMEFQRFITLLKDALEAYKREKKGKKEASEQKKRDKGKKTDSEEPDKSRDEDTDEDEERLEEEQNEDEEVDN
The following text describes a protein:
Function:
Required for nuclear fusion, chromosome disjunction, and nuclear segregation during mitosis. Probably required for the formation or stabilization of microtubules during mitosis and for spindle pole body fusion during conjugation.
Miscellaneous:
MISCELLANEOUS: Present with 300 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=And mitotic spindle.
Sequence:
MDRYQRKIGCFIQIPNLGRGQLKYVGPVDTKAGMFAGVDLLANIGKNDGSFMGKKYFQTEYPQSGLFIQLQKVASLIEKASISQTSRRTTMEPLSIPKNRSIVRLTNQFSPMDDPKSPTPMRSFRITSRHSGNQQSMDQEASDHHQQQEFGYDNREDRMEVDSILSSDRKANHNTTSDWKPDNGHMNDLNSSEVTIELREAQLTIEKLQRKQLHYKRLLDDQRMVLEEVQPTFDRYEATIQEREKEIDHLKQQLELERRQQAKQKQFFDAENEQLLAVVSQLHEEIKENEERNLSHNQPTGANEDVELLKKQLEQLRNIEDQFELHKTKWAKEREQLKMHNDSLSKEYQNLSKELFLTKPQDSSSEEVASLTKKLEEANEKIKQLEQAQAQTAVESLPIFDPPAPVDTTAGRQQWCEHCDTMGHNTAECPHHNPDNQQFF
The following text describes a protein:
Function:
Regulator of mitochondrial fusion. Acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MSDETVSRSQFSLKTYAVRVFALPVSWYYSLSQIKFSPVAKKLFMVTAVSAVSVIFLAHHFKRRRGKQKGKVLPWEPEHLLLEHTRRAASEKGSSCSSSRQNLTLSLSSTKEKGSQCCNYPNGGLLSRYSGSAQSLGSVQSVNSCHSCACGNSNSWDKADDDDIRLVNIPVTTPENLYLMGMELFEEALRRWEQALTFRSRQAEDEACSSVKLGAGDAIAEESVDDIISSEFIHKLEALLQRAYRLQEEFEATLGGSDPNSIANDTDKDTDMSLRETMDELGLPDAMNMDSADLFASATELAEQREAQQTFSLESFCPCPFYEEAMHLVEEGKIYSRVLRTEMLECLGDSDFLAKLHCIRQAFQLILAEADNRSFLAESGRKILSALIVKARKNPKKFQDVFDEMINFLEQTDHWDSTELELAARGVKNLNFYDVVLDFILMDSFEDLENPPTSIQSVVNNRWLNSSFKESAVASSCWSVLKQKRQQMKISDGFFAHFYAICEHVSPVLAWGFLGPRNSLYDLCCFFKNQVLFFLKDIFDFEKVRYSSIDTLAEDLTHLLIRRTELLVTCLGADALRHATTCTSGHSHAVPTALLEAKVQ
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKIFLENVIRDAVTYTEHARRKTVTAMDVVYALKRQGRTLYGFGVSVRLSKNRLKPKPNREFKNPNLVLQFSINHCSAALYKHTVCHLKSSSIIFSAKLNRRFCWILRFTLMESQKKRKAKSLICEYFERMDVDDDKKKDKCNHCSQVCDKDGNVNGTSMKQHSTLCNQNPKNLPNNSEDERKRKALAKMIILDKLPLSSVQTVSFKRFMEALCPDFTIPSLLTIARDCCEYYSEKKKKLKKLFTENEQRVCLTVDIWTSEEGLDYMCLTAQFIDDDWNLHNKMINFKLVDSDDGEEIGSTIIECLKEWGIENVLTITIE
The following text describes a protein:
Function:
Glutathione S-transferase, which conjugates reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Sequence:
YLFVMTNRMKLLNYSFEGLPNLKKLDEIMRQHPAVKRVLEQEGAPHTLTD
The following text describes a protein:
Function:
One of the last ribosomal proteins to be assembled in the 50S subunit, it contacts a number of helices in the 23S rRNA, acting as molecular glue. The simultaneous presence of uL16 and bL36 probably triggers ObgE's GTPase activity and eventual dissociation from the mature 50S ribosomal subunit.
Sequence:
MKVRASVKKLCRNCKIVKRDGVIRVICSAEPKHKQRQG
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MVSDEKTARLTRVINKLQSVPYQINTKLLCHLVKCKDIYHASGLLMPSILASIDRTEGTVRLKHHYLNDKEMKKYFSLKDLINIWIKNIQSACYEQYILKLADALQNYNLYFPTFLDFRGRNYRYGPFHYHERDLVRSLILFAQSGVTDTPPDKGSQGIRTFMASTAFHYSKYWKNYNEGIIWFIKNIHECPDLNSNKADIVLDRLANLARKARHPFQFLSSVITLKNRDSDKIARTPIHLDASASAYQMLSYLLGNITMARNTNLISENNKINNIYEIIDSDFKKYIERKYGEHIITRYVCSLFDRDIIKNIFMPIVYGKSKFSTAIDLLGKIGSYMVVEDLKTIIKECYNFWESEYKDMRNLMHLVASISWVSGFINKPVIYSTEYWITVQDYIIMEPVKITVKYQTHGMVLILK
The following text describes a protein:
Function:
Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction; [Medin]: Main constituent of aortic medial amyloid.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: It is unsure whether Met-1 or an upstream Met is the initiator as the upstream Met corresponds to polymorphism rs1879326.
Subcellular Localization:
Membrane; Peripheral membrane protein. Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Peripheral membrane protein. Note=Located in the acrosomal region of zona-pellucida bound sperm.
Domain:
The F5/8 type C 2 domain mediates high-affinity binding to phosphatidylserine-containing membranes.
Sequence:
MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKGYAGNHCETKCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC
The following text describes a protein:
Function:
Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSTTDEWSSNSNDAIHIQLVKPNGEVDFEFHPANTYSIFGDAETIYGYKGLNVTIKFLMPWMKPSLTITSNETIPSTSGVTPTDISSILKEYIPFTNTDGEATASSDTLSFLPKEPLCSYVKNEKTFKIFKTSVTAAEKLMQNLQVFPLFFIDGGSFIDLEDPQWFVYFVFEVQDEQLYLRGYSTVYHYYVWKKDDSSALRARISQFIILPPFQHQGHGSKLYKTIVGDFMGDKNIVDFAVEDSSESFDALRDRCDFTRIAESGLFDREEFRAPLSTQWISLHRLPYKLNKRQFSRCCELALLSKLNNQLASERKAYRLTVKERIFRQNIDVLLQLEKPERLEKLQEAYKNQLDEYKRILAEGFPIPQAEKGDMPPAKRLKTSS
The following text describes a protein:
Function:
Contributes to activation of the hypersensitive response, a form of programmed cell death, upon fungal infection. May sense the presence of fungal material and relay the signal to WAK17 isoform 1 (Probable).
Sequence:
MAAVQFAAAGVLTGLLALATLASCNTDGDILYKQRLAWEDPNNVLQSWDPTLANPCTWFHVTCNLNNSVIRVDLGKAGISGPLLPDLGALESLQYMELFGNSLNGSIPSTLGNLTDLISLDLWDNLLTGPIPTTLGSISTLRYLRLYENNLTGPIPPSFGNLTSLLELKLHRNSLSGSIPASLGNIKSLQFLKLNENMLTGTVPLEVLSLVVVGNLTELNIARNNLDGTVRSSGLRVTAVIQDMRIA
The following text describes a protein:
Function:
Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively. Required for the biosynthesis of phosphatidic acid via the DHAP pathway, where it reduces 1-acyl DHAP to lysophosphatidic acid (LPA). Also has triacylglycerol (TAG) lipase activity. Involved in the mobilization of the non-polar storage lipids triacylglycerols (TAGs) from lipid particles by hydrolysis of TAGs. Required for spore germination. Plays a role in cell wall biogenesis, but this effect may be indirect by affecting the activities of cell wall synthesis enzymes. Lipolysis of TAG by AYR1 is essential for starvation-induced autophagy. Forms an NADPH-regulated cation-selective channel in the mitochondrial outer membrane.
Miscellaneous:
MISCELLANEOUS: Present with 3671 molecules/cell in log phase SD medium.
Subcellular Localization:
Lipid droplet. Mitochondrion outer membrane. Endoplasmic reticulum.
Sequence:
MSELQSQPKKIAVVTGASGGIGYEVTKELARNGYLVYACARRLEPMAQLAIQFGNDSIKPYKLDISKPEEIVTFSGFLRANLPDGKLDLLYNNAGQSCTFPALDATDAAVEQCFKVNVFGHINMCRELSEFLIKAKGTIVFTGSLAGVVSFPFGSIYSASKAAIHQYARGLHLEMKPFNVRVINAITGGVATDIADKRPLPETSIYNFPEGREAFNSRKTMAKDNKPMPADAYAKQLVKDILSTSDPVDVYRGTFANIMRFVMIFVPYWLLEKGLSKKFKLDKVNNALKSKQKNKDD