lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis.
Domain:
The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.
Sequence:
MSRERPPGTDIPRNLSFIAALTERAYYRSQRPSLEEEPEEEPGEGGTRFGARSRAHAPSRGRRARSAPAGGGGARAPRSRSPDTRKRVRFADALGLELAVVRRFRPGELPRVPRHVQIQLQRDALRHFAPCQPRARGLQEARAALEPASEPGFAARLLTQRICLERAEAGPLGVAGSARVVDLAYEKRVSVRWSADGWRSQREAPAAYAGPAPPPPRADRFAFRLPAPPIGGALLFALRYRVTGHEFWDNNGGRDYALRGPEHPGSGGAPEPQGWIHFI
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MFFSQVLRSSARAAPIKRYTGGRIGESWVITEGRRLIPEIFQWSAVLSVCLGWPGAVYFFSKARKA
The following text describes a protein:
Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Sequence:
MPASRLGDCTGKSHANTNIYYWNVIPWKRIQNLFGSNVAAARSYRKLTRMNTASGRLEAQGTASLFGGSCVNDLSTSSQMLLCSSSNSCDTTSSHSASFSGSSLSSPPQHAMSSSSPDPSYSTLFPTFNTLNKIPHASRAAEMSSCEDSTRMQPKETLDTVAPLNHMFLDQNAFQRNVLPLHIGRTQPLFTQFSECKTTGKSTMVLDDRSCCPVIASKKDESIKSTTLLKKADDASTDDTTASNHGSFPMSRDRDHPLSFTTAPSKMESETVFQTAPAARTHVSTKPSRMDMFTKGGISHWNQRTTNTLTVDSTLDGQGHVQPNSYMSSLHTSGSSLSTALHISTSSKPPRAPAFGYGNAASSAANSKPGRFKLVTDQRLFCNLSKSDFGSSTAVITAEKCVLSEHQRPSTRRSKLPQSRKQVGLQPRLLHTSDNCFLTEQRNDTTLSDSTASDHKCIPLLSRRTRPISTMDMDIDLRTVTTAVCRSILPTQKHGQPPIKMRRANTVIGFGQSEHPEQPHLHHQPQLSLSSPFCTSDETSLLPSMLVPGKDMIRRITVDTLAQVLDGKFDQIESFHLVDCRYGYEYAGGHINGAKNVTSVQDLEHYFTSPPSNNQTVIVFHCEYSAQRAPQMALHFRSMDRNINAMAYPKLHYPHIYVLSGGYREFFKSYMFRCEPQAYVEMTDAQHTEDYKAGVIQNRRQFRKAFSDGFLR
The following text describes a protein:
Function:
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
Subcellular Localization:
Secreted.
Domain:
The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues; The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
Sequence:
MCTKTIPVLWGCFLLWNLYVSSSQTIYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKISAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIIILTRNDFGHPTLKLQDCYAQLSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIASEVKALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKVTLSSSESSAWLVYSTHWKTSPTPPSHPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGAFNVTLSTEEISNHFVQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPMINLQPGNFTLDIPASIMMLTQPKNSTVETIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISFINSDIEVLEGFLLISTDLKYETSSKQQPSFHGWEGLNLISGQWRGKSAP
The following text describes a protein:
Function:
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MEEIKNDSNPSQQHQHGCHDPVREETVDNNVMEVAEVDTDEEFASNPFSQLFESLQHAKTAAKRFKNATDLKETTLIGQMKMNLKDSAELLQLDITADELIVNDILQRILLVTADKHFSKRADKISVKIPQTIVLLPLSNELTEDRCCLNFDIVDEALIERLSMADIHPNVITFRPSNKAKDDQSYRVSLALVAEPNPIVYLFECHRRARLVLQEQSADNQCSRQAAEKCKVIVATFVGSCLLTPDILSGQDTNKQFDSLLTDRQYSGTPELYEFLKDILISYPDTNDIEQIFQYSIAPIFNIQSIKYEDIHPKLIRLCNFSQHEHLLKFLIESSPWLPKGLNVTGKSFERTLLGSLLCYSSIVPALPLLQGFGFTTLHTLSPDFSNPTMMRPAQVEHITSSLRTQREYVLELIFTSASQMHFHELAGDAFFLNLSSILMELCDPFMIISSPKLLKIDPEACIAKSSVTQAHGIFRLNLYNETKLADQTSSALPTTITVYKNLMERLAKLQNMVSTPEGLANTNLRQEFEAGVSQQLAMKAHVLDPKLLERILNFYNVTAAWALQISNTDGKHYNQIDLNQEMLSTSIEVPKKFAMLPEFIVDSLTQFIIFLGHFAPEILEMQCAKLEPLVIFITGLMGSSKFAKNPHVRAQLADALARLVPNDAHKRMLEQIFLESKQIQDSLALAVLNVYVDIEKTDNSVEFEQKFSYRHNIYNILEYLWTVPAYKEKMIKLSEEVTVGEQGLKDVIFLRFIHLLTNDAVFLLDEALSTLSDIKKLQEELADEELSSQARREKLQQLSFSSRMARSLNILGNQTVNALTLLTQSIVRPFTEIGMVDRIASMLNYFSVRLAGPKRGTFKVKDFSEFHFKPDQLICNIALIYTQLGQSESFCKAITEDERSYTPQLFYQIERVLNKLARLDIVSEFKELHDKVTKFAAEKKEIEEAMPEPPEEFLDPIMNTLMVNPVILPTSGKIMDKATITRHLFSSQNDPFNRLPLQLDDLVPHQELKERIEQWLRDNKIILPDQND
The following text describes a protein:
Function:
Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
Subcellular Localization:
Secreted.
Sequence:
MPQKLSIQQKSFGTAELTSVWDKSQKETRTKAPCVNMTSKLAVALLAAFVLSAALCEAAVLSRVSSELRCQCIKTHSTPFHPKYIKELRVIDSGPHCENSEIIVKLFNGNEVCLDPKEKWVQKVVQIFLKKAEKQDP
The following text describes a protein:
Function:
Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into the sesquiterpene (2S,3R,6S,9S)-(-)-protoillud-7-ene.
Domain:
Contains several highly conserved motifs that are important for catalytic activity including the aspartate-rich 'DDxx(x)D/E' motif and the 'NDxxSxxxD/E' motif, both of which are involved in complexing metal ions to coordinate the binding of the isoprenyl diphosphate substrate in the active site.
Sequence:
MSLSLGDIKFPDNWDLIPNEKNYIDYVYKESIELEVWRPNNKRDLMAHNNVVSLAKYFWPHVDFNRLVMGGELMVWFFSFDDVLDAGIYTDEKQMDLVKRMDNVFINGTVESDATGPEKMALHLRKKCEVMCGKRRKDTFNRFISSCVQWVDSIIPFNKLRSAQGTSPHLELYSYLRKVNIGAYPCVTLTEVMLDHEIEYYIWSDPKWIKMNEDIAIITTLINDLVSYEKEVNDQAGDLNPLYFLQNQKNIPLPDSYKQVVDLIDFWVKDYQTMEQSLLNEMEFKDSKQRSDMEFILEHLRYLASGSKKWSMQTPRYCSPTSPFIEMRTKPSTPVMNSTKKQKIDHVPSQSFISTPIDLNN
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MQQHHLQQQQQQQQQQEQQHLQEQQQHLQQLHHHAHHHLPQPLHTTSHHHSAHPHLQQQQQQQQHAVVASSPSSVLQQQQQQSTPTTHSTPTHAVMYEDPPPVPLVAVQQQHLPAPQQQQQLQQQQQQQQQQLATTPVAGALSPAQTPTGPSAQQQQHLTSPHHQQLPQQQTPNSVASGASSNLQQQQQQQNAAVAPGQTQIVAPTTASVSPSSVSSQKEDINMSIQLAPLHIPAIRAGPGFETDTSAAVKRHTAHWAYNDEGFNQHYGSGYYDRKHMFAYPYPETQFPVGQYWGPNYRPDQTTSAAAAAAYMNEAERHVSAAARQSVEGTSTSSYEPPTYSSPGGLRGYPSENYSSSGASGGLSVGAVGPCTPNPGLHEWTGQVSVRKKRKPYSKFQTLELEKEFLFNAYVSKQKRWELARNLQLTERQVKIWFQNRRMKNKKNSQRQANQQNNNNNSSSNHNHAQATQQHHSGHHLNLSLNMGHHAAKMHQ
The following text describes a protein:
Function:
Probable transcription activator that regulates root development by controlling cell proliferation in root meristem. May mediate responses to auxin in the root. May act as promoter of the flowering transition through up-regulation of SOC, FT and LFY.
Miscellaneous:
MISCELLANEOUS: XAANTAL is the Mayan word for 'go slower' in recognition of the retarded root growth phenotypes of xaantal mutants.
Subcellular Localization:
Nucleus.
Sequence:
MARGKIQLKRIENPVHRQVTFCKRRTGLLKKAKELSVLCDAEIGVVIFSPQGKLFELATKGTMEGMIDKYMKCTGGGRGSSSATFTAQEQLQPPNLDPKDEINVLKQEIEMLQKGISYMFGGGDGAMNLEELLLLEKHLEYWISQIRSAKMDVMLQEIQSLRNKEGVLKNTNKYLLEKIEENNNSILDANFAVMETNYSYPLTMPSEIFQF
The following text describes a protein:
Function:
Positive regulation of the major cellulase and xylanase genes (cbh1, cbh2, egl2 and xyn2). Binds to the 5'-GGCTAATAA-3' site present in the cbh1 promoter.
Subcellular Localization:
Nucleus.
Sequence:
MDLRQACDRCHDKKLRCPRISGSPCCSRCAKANVACVFSPPSRPFRPHEPLNHSHEHSHSHSHNHNGVGVSFDWLDLMSLEQQQEQQQGQPQHPPPPVQTLSERLAALLCALDRMLQAVPSSLDMHHVSRQQLREYADTVGTGFDLQSTLDSLLHHAQDLASLYSEAVPASFNKRTTAAEADALCAVPDCVHQDRTSLHTTPLPKLDHALLNLVMACHIRLLDVMDTLAEHGRMCAFMVATLPPDYDPKFAVPEIRVGTFVAPTDTAASMLLSVVVELQTVLVARVKDLVAMVDQVKDDARAAREAKVVRLQCGILLERAESTLGEWSRFKDGLVSARLLK
The following text describes a protein:
Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYGQQSALGLPMRGMSNNTPQLNRSLSQGTQLPSHVTPTTGVPTMSLHTPPSPSRGILPMNPRNMMNHSQVGQGIGIPSRTNSMSSSGLGSPNRSSPSIICMPKQQPSRQPFTVNSMSGFGMNRNQAFGMNNSLSSNIFNGTDGSENVTGLDLSDFPALADRNRREGSGNPTPLINPLAGRAPYVGMVTKPANEQSQDFSIHNEDFPALPGSSYKDPTSSNDDSKSNLSTSGKTTSSTDGPKFPGDKSSTTQNNNQQKKGIQVLPDGRVTNIPQGMVTDQFGMIGLLTFIRAAETDPGMVHLALGSDLTTLGLNLNSPENLYPKFASPWASSPCRPQDIDFHVPSEYLTNIHIRDKLAAIKLGRYGEDLLFYLYYMNGGDVLQLLAAVELFNRDWRYHKEERVWITRAPGMEPTMKTNTYERGTYYFFDCLNWRKVAKEFHLEYDKLEERPHLPSTFNYNPAQQAF
The following text describes a protein:
Function:
Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MKNRFDVLVDFVIESITGGVREVYVMLCDGSTYLITSLPSQRARAVARWLLSRQPFKTSLQAIIAKYRSVYYLHERGRDISEARLDGNGLYIFGDHDGLSREDEELLAKHAEWISLGSTPYMSWHAAAYLAYLLKRQV
The following text describes a protein:
Function:
This protein binds a wide variety of chemical odorants.
Subcellular Localization:
Secreted.
Sequence:
AQEEEAEQNLSELSGPWRTVYIGSTNPEKIQENGPFRTYFRELVFDDEKGTVDFYFSVKRDGKWKNVHVKATKQDDGTYVADYEGQNVFKIVSLSRTHLVAHNINVDKHGQTTELTELFVKLNVEDEDLEKFWKLTEDKGIDKKNVVNFLENEDHPHPE
The following text describes a protein:
Function:
Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (By similarity). May also play a role in recruiting clathrin to endosomes (By similarity). May regulate growth factor-induced mitogenic signaling (By similarity).
Sequence:
MEFLLGNPYSTPVGQCIEKATDGSLQSEDWTLNMEICDIINETEEGPKDAMRALKKRLNGNRNYREVMLALTVLETCVKNCGHRFHVQVTHRDFIDGILVKIISPKNNPPTIVQDKVLALIQAWADAFRSSPDLTGVVHIYEELKRKGIEFPMADLDALSPIHTPQRSVPEVDPATNMHTSQTQKRDSFSNLSNSKSTSTPYTAPGGPPPNVGGPISANSEQIGRLRSELDIVRGNVKVMSEMLTEMTPGQEGASDLELLQDLNRTCRTMQERIVELISRVSNEEVTEELLHVNDDLNNVFLRYERFERYRLGRSAQNTNGVLSDVTEDNLIDLGPGSPAVVSPMLANTAPSNLSSQLGGLDVGTNSVSSTLSALPTTNPKDDFDMFAHTRTNSLADQRKNVTYEDPQALGGLVSALDVRKQNIGGIPVSQPSDMDDIEDWLSKDLKGDELEEGVTSEEFDKFLEERAKAAERVPDLPSPPTGEPAQPMNPAGRKKQESSEDKLFAL
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSVPSVFFPERMDYIEIISPTQSAAALIQEIAENGKIQLVDNNSGNATMNKRYTEVYLQCEEATRSLSFMKSQLQAAKKLPPQPTLHHALHASHGMTLQEVVNAILQADTELREKSTMYERIKDQLRQLKEKQNLLEFYIPNLDSDDAQDRSEVSESTRSLPYNDNMEMQSFNNLPSCTGYVANESIARLQKIILRVTRRNAVIHFGESNSKQTPFLVFVSSSVALQKIKAIAQSFSKNVYEFPTQMEEITRLRNELNGEISQTRSIAIQARSDNLRYLDEVAVHFWDWDARIVRESQIWSTIDFGDFSRDEGYVYYNGWMPRRYINELGPLAERATHNANSPVPIRTNNTQAEAQQREPPTFIETNNFQYSFQLFNDAYGVPNYNEINAGAFYCMYPFLFGIMFGDMGHSIFYLLVTLGMFIMVPLMKKKGNSMGGMLEMIDRFKWFLLFASVCSFYCGFLYNETFCLPINFFGSHYHVDDRNSNPQLTVYKKNSTSIYPFGLDPAWFFKDNELIFSNSLKMKMSVIVGMAQMIFGLILSFINNFVQRDWVSLITLRVPELLYLVPFYGYMVVIIIWKWCTNFKGNPSLYNVNVQKDGINLIQVMIGMILSFGSEDDDLKLYEGQWGAQAVITTIFFCSIPVFLVLRPCFEAYLHHGDPNWSVLEAIVMNLIHVIEFVLQALSHTASYLRLWALSLAHSQLSKVIWEELFLNGFNYSKTHDGPWTNGTWVLTFFVFLAFTVMTAAILLGMEAFSALLHGIRLMWVEFCSKFYGGGGYEFKPVSLKNTLKNAGYNDF
The following text describes a protein:
Function:
Participates in transcription elongation, termination and antitermination.
Sequence:
MKGNIMDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLDNILRVEIPTQTVQVEKNGKRKEVEENRFPGYVLVEMVMTDEAWFVVRNTPNVTGFVGSHGNRSKPTPLLEQEIRDILVSMGQTVQEFDFDVEIGQTVRIIDGAFADYTGKITEIDNNKVKMIISMFGNDTVAEVNLNQIAEL
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MEVGSLNVIEAIALGENETEVPKKRENKKDIDDFVKHTIWITYRKNMPLIKEKTTDSGWGCMIRSLQMALAQTFLSIVLGNNWKYEDNCINTERNIFHIKSIINLFGDSTGSLFSIHRLVARASTRGVTEGQWWGPSFASDIAAEHINEMRVFRTRGYVAKLGSIIGSKIEELIKDGGGFNPCIIFVPLRLGPESPENEFKPLLKTIFDIPQCMGMIGGKPGYAHYFHTFDGTNLYFLDPHTTQNAIDMKGDWSYQSYFCKDNKSMLYSKMDPSISLVFLVKHANDYEHFKKSFENKTFSKLFTFKDETEKELNSDDFISLDDDDIDLIK
The following text describes a protein:
Function:
Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Is essential for chloroplast development (By similarity).
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MACSTHLLSQSLYPLNRANPAAARGHLRFQASPSVRLGSGTSRRRALGLRVAASAEQGRRQVEVEYDLQAKFNKLADQIDQNAGITRLNLFSPCKINVFLRITGKRPDGFHDLASLFHVISLGDTIKFSLSPSKSKDRLSTNVAGVPVDESNLIIKALNLYRKKTGTDNFFWIHLDKKVPTGAGLGGGSSNAATALWAANQFSGCIASEKELQEWSGEIGSDIPFFFSQGAAYCTGRGEIVEDIRNPLPANLPMVLVKPPEACSTAEVYKRLRLEHTSQTDPLVLLKEITENGISQDACVNDLEPPAFEVLPSLKRLKKRIIAANRGDYDAVFMSGSGSTIVGIGSPDPPAFVYDDDDYKDTFVSEACFLTRNENEWYREPISSKITSEEDLPPEVASVSD
The following text describes a protein:
Function:
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
Sequence:
MASIAGSLARQQLRQFVGRSTIISTPSCSYSTTSSASRNTPSASHSTESRRLRSAAAIAHSQFSTCTHVHSSWPAGAVGSAESDKLPPPVKGKAKTAPSIPSPSRSKTIADIQALKHHPSGSIPIVCLTAHDFPSALSVRAANVDLCLIGDSLANVALGYTSTQPLSLDAMIHHCQAVKRGLDAPLLATASLLDGIDLPQPPLVIADVPFGATFGSLDSGVAAVVRLIQESGVDGVKIEGSYETIPLIQRLTSHGIPVMGHLGLQPQRVGSTSGYRVQGKTAAQAKEMLDAALALEQAGCFSIVLECIPTRVGEHISRKLSIPTIGIGAGSKTDGQILVMNDMIGDLTGAGHVLAQLSVRTDADQARAAASAPLPTSSDLMPPAPKFVRNFSLAMGTSIGALRIAAVQAYTQAVRTREFPDDDKEGYKIKTDEWIAFLQLVSESGTK
The following text describes a protein:
Function:
Encodes a member of the mid-SUN subfamily of SUN-domain proteins that is localized to both the nuclear envelope and the ER. It is involved in early seed development and nuclear morphology. [TAIR].
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MQSSRKGKFQIKAAKQIEETNQLWKVSLSVIFLSWGWFFLTNIYISYERSFEDGLGALIGGLAINNIGFFQLNTMDILSVLEYDENNDQNHKISANNDGVLTRKGNKNGSSTSSWNKMSSSGIIVKEFISIVEKDMVLASVSINKKLPEEHVSRESEESVQTSDSFCRAKEKDQNAAGEHQELRSKLVKNDAKGIKSSRVVPSLGEYKKKTITAKEKLYGTSQAGSVKNRIEPGGKEYNYASSSKGAKVLDFNKESKGASNVLSKDKDKYLRNPCSAGAKHVVIELSEETLVITIEIGNFEHYSSNLKEFELLSSLTYPTDSWVKIGNFTAANVKHKQRFVIPEPKWGRYLKLNLLTHYGSEFYCTLSVLQVFGVDAVETMLEDLISVQDGLHRFESEEQTTISEHSLPMSEATTDAHDDVYTKILSEIYYATSKMEQHHDSMKNGAAESVTETRLSQNGRMPGDAVLKILIEKVRSLDVNYAVFERYLEDLSNRHAEIFKDIDSEIHGKDLALDKIRREVQMLQSNQEAFKRNIIDLLDWKLRSSLQFDILFNSNSILRSQFDKIGENQVDMENQMIMVMIIISLNFGCFAVIKIVTDILKGICGMSQILGRMNSSWMMSFVCSTIVAFLIVLY
The following text describes a protein:
Function:
Catalyzes the cyclization of farnesyl diphosphate (FPP) to the tricyclic sesquiterpene pentalenene in the biosynthesis of neopentalenolactone antibiotic.
Miscellaneous:
MISCELLANEOUS: S.avermitilis does not produce pentalenolactone itself in vivo but instead a group of new metabolites that are neopentalenolactone derivatives.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MPQDVDFHIPFPSRRSPDFERARADHLSWPRALGLIGTDAAAERHSRGGYADLAARFYPSATGADLDLGVDLMSWFFLFDDLFDGPRGEDPQETRKLTDAVAAALDGPLPTSAPPIAHGFADVWRRTCQGMSPAWRARSARHWRNYFSGYVDEAVSRHLNTPYDSAGHYLAMRRQTIGVQPTVDLAERSCHCEVPQRVFDSAVLFAMLQIATDTNLILNDIASLEKEEARGELNNMVFILMREHGWTRGRSIAHMQDGVRTRLEQFLLLEACLPKVYDTFELTAQERESAEKYRMDGVRSVIRGSYDWHRSSGRYAADYAIAASYQGYLEELGSTL
The following text describes a protein:
Function:
Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate; Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate; Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.
Sequence:
MSQTSLTPGQRFREAVATEHPLQVVGTINANHALLAKRAGFKAIYLSGGGVAAGSLGLPDLGISGLDDVLTDVRRITDVCDLPLLVDVDTGFGSSAFNVARTVKSMIKFGAAAMHIEDQVGAKRCGHRPNKEIVSQQEMVDRIKAAVDARSDDSFVIMARTDALAVEGLQAAIDRACACVEAGADMIFPEAMTELAMYKEFAAAVKVPVLANITEFGATPLFTTDELASADVSLVLYPLSAFRAMNKAAENVYTAIRRDGTQKNVIDTMQTRMELYDRIDYHSFEQKLDALFAQKKNA
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MLLDEDPAALISQCTSHFKIANDKESLNRISDSLSTLSTFRTQELQSLSAKLSALSRTHQTLAANHSHTLTQHNAVSHASEILRLDTEKFKIAKQASDLEIEGERLQADLVRLGNVSGELEEEGVEGGAVERPGEDATVLKLKLYRSLGIDVEADRTTGEYNKAVIRNANKGDVHVVQIDPKFSRHFYTNYFWRTM
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MANKRKRQRKRLRRVPAALRRVYGDLVQTLEAAILSLLPPPPSSPTECRCRGRLCLGCGTPAYLLRQDDPPDYRILLTRGLCVLSCDAPPPPRVFHGDDAPQRVLVRNARELILDNMLETMNVLCNGHDKESHFNIAGEFLCTSTWDLLLHRIGFQLMVFLLRFSSIFIPVRNKSYYQVTGHPMDKIFEGSKFLKTTSTSSNQQPFFPEAMQNMGCSRSLKRKQRDMSGRSNMGAAAVSVCSKSKDLGDKRDNGSKVSCGKFERVGGRTEVVQFDGGEPNIKILWDHDSSQNTLSKCGGPILHDSVFQSYFDKLHLEKLKSPCTKCHNNEKESICTDMPGLCLSRKYRKHRRLYSWQRRRKYKGPEENIPGKNNKIRLQMKFLDSDCSLCHWPSEPSVPASTEEDIMKDFELTASKDTEASREKCSHLMLSQDMCQGQITFSTKKTHHRPRSETNDASEGQHHASLKNLSIQPLDFAVSSLYNNRFTPNELFPEESDCSASKNQLNLHSHFEKVGSMCFYCLIMQSSQKVEIRDQIDRSFIFYNRSSAYTVFPKNHILNLLKPNDCSAIRLMKHIFGFPDRSKNFMTCTDCSIGCAIESQCL
The following text describes a protein:
Function:
Has E3 ubiquitin-protein ligase activity.
Domain:
The RING finger domain is required for ubiquitin ligase activity and autoubiquitination.
Sequence:
MLLGASWLCASKAAAAAAQSEGDEDRPGERRRRRAAATAAGAGEDMDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRAGSCPIESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF
The following text describes a protein:
Function:
Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.
Subcellular Localization:
Nucleus.
Sequence:
IMPRIPDRWLDYEKMGQVIEGTDILAMKVPLYEGITRNLPKKEHFNWKIAVDTAEERGHRIGTVVDLTYSTRYYQPRDFTNNGISHHKIFVPGQIIPPPKVVSDFTSIMSKFEKNKQSDNEVIAVHCTHGLNRTGYLICRYLIEEKKFKPKDAIEKFNSARGHKIERENYLKDLISLEKEKPVKTEQSPQKTKDNPPKPNNNSQKPKVSKTTDEVDLKLKHQNKLKHKLRKPDRDGYFRHNERQQNYYHHQPYPQQYKQQWYPDYHQERFNQYNHQGHNRGESWRKEPFNAFHKSFQQAPHYSHPHESGYNRGESRRKGPFNAFQESFQQAQHHYPPNRQWSNYSNWN
The following text describes a protein:
Function:
Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSFAILGFIALGGAVGACARFLVSEICVTLFGRGFPIGTLTVNVVGSFIMGVLIACVENEWLSPYPWKQVIGLGFLGALTTFSTFSMDNVLLMQQGAFFKMGANVLLNVILSISAAWIGFHWLMKS
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MCLVELDAAFYQYLLENQFRPLLNVAQCFGFLPYPFDFQRQAEVKNIVLQKMLTILNRTFGLAMIGTVLTCCVSLYVCYPSYMYEEDYPPVLNIAYHLENWLKIVTVLVAVLRSQTSTAYFRETVNSLVQIMVQYDQGWRIERKLASVATVSKRLSVVFLLDDFTIATGLYFIVEGAPATLINLCYIPPFIAIVINVLHYYALFGTISGIMSCSNDTLYGITVEGKKDRHRSCSGRKSNTKENDITTIDKLVRLHTALLHLTWKTNAHYGVLLLIIMLYSFIQISVILAELYFDNYDLPLVFVGICLTHAAVYFMFFLIIAHANHAIIMENERTLLLLLDINCIWNSELNGMVDYYFMQVSNLQDTHQACGMIKLDMQLVPNVIAVITSILFILMQFSDADRNQDIKTVYRLDNIYNISVET
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
Sequence:
MDSLAEPRWPPGLAVMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQCPTCCVTVTEPDLKNNRILDELVKSLNFARNHLLQFALESPPKSPASSSSKNLAVKVYTPVASRQSLKQGSRLMDNFLIREMSGSTSELLIKENKSKFSPQKEASPAAKTKETRSVEEIAPDASEAKRPEPPSTSTLKQVTKVDCPVCGVNIPESHINKHLDSCLSREEKKESLRSSVHKRKPLPKTVYNLLSDRDLKKKLKEHGLSIQGNKQQLIKRHQEFVHMYNAQCDALHPKSAAEIVQEIENMEKTRMRLEASKLNESVMVFTKDQTEKEIDEIHSKYRKKHKSEFQLLVDQARKGYKKIAGMSQKTVTITKEDESTEKLSSVCTGQEENMTSVTNHFSQSKLDSPEELEPDREEDSSSCVDIQEVLSSSESDSCNSSSSDIIRDLLEEEEAWEASHKNDLQDTEISPRQNRRTRAAESAEIEPRNKRNRN