lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.
Miscellaneous:
MISCELLANEOUS: Present with 3690 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSLIHPDTAKYPFKFEPFLRQEYSFSLDPDRPICEFYNSREGPKSCPRGPLCPKKHVLPIFQNKIVCRHWLRGLCKKNDQCEYLHEYNLRKMPECVFFSKNGYCTQSPDCQYLHIDPASKIPKCENYEMGFCPLGSSCPRRHIKKVFCQRYMTGFCPLGKDECDMEHPQFIIPDEGSKLRIKRDDEINTRKMDEEKERRLNAIINGEV
The following text describes a protein:
Function:
Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of baf-1 during mitotic exit. Coordinates the control of baf-1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of baf-1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex.
Subcellular Localization:
Nucleus membrane; Single-pass membrane protein.
Sequence:
MGRKSAILAVILAIIYFRSNFSKMSNTPVQETEGPVYVAYSMEDMLKSPRDLYKSVKEVAKFVNSAEGKSMSARFKKFGTPREAMDFLAYGDAPTTPKTVPPVAPTEPNSPFSGVNRIQMNEFKKYVEKGDMENFLRLVDSNPRFLVNTGGDVASIVMEGFRYNALHIAAKAGQTEIIAKILELIQNIDFLIRLYGTGADDVTLRKINILDSYLNTPDKGNSDTPLHFASKFGKIGVVRVLTENSATDRTLLNKSGKSALDCAGERYTGEDKDMVQRDIHLAIEGFYVFLHRNPTTGSTQLTVSQKPPATYSTSPTTATVTVSAQAGPFFTEREARDFAKSWQTAGKELKRTDFDKGWERVGRVLAEQSEAMWRETWHFLGSMELLDLGSEQGLGVLEAFLREKRRGNLRNSEISEISTKKSIFRRGIHARKLDFGILDGEKSAEISENLTPDGSDSADDEDDDDIFYDTFSEIPAAAEKSINDPDDTLGSLTDRFAAISIFSPLPPPPPPQWSNSPNFDYSEGEDSFATPPTTPPPTFVADDEPCKIDNDLFEVLAQISSELISKFPLTQDYVQKLGKLTAHDRSTWRPIDSPARCDSRRKI
The following text describes a protein:
Function:
May function as histone H3 lysine demethylase and be involved in regulation of gene expression.
Subcellular Localization:
Nucleus.
Sequence:
MATTITKNGSLTEANIDDGEIGDTVVKDEVAVDDKKRRHPIVCGLLAGDNHKRRRAVDDRDRYLACRAPSSLRSPHTLLLNHEKVDEINFISPCYNAVRSSSTAGLLAEKKENQDIKEERTDLMDDKGIEEQNRVSEPEAEAKQGLQMKKKRGRKRGWKKHNGNTGAAIKSEKSSSTVRKQEAINGNEEQNRVSEPEAEEKQGVQMKKKSGRKRGWKKHNGNTGAAIKSEKSPSTDRKHEAIKGNEEQNRVSEPEAEEKQGVQMKKKRGRKRGWKKHNGNTGATIQSEKSPSRDRKHEASNSSMKDGFKLNNYAKNMVLNENGNLVHVLQGKSNMCHQCQRNDKGRVVQCQKCTTKRYCVPCMTTWYPNMTEEMFAECCPVCCDNCNCKHCLRDVHPKVKKKIDFKPNDDQKVRYSIYILHVLYPFLKRINEEQIKEKAIESKIQGSSLSEVRLKKVKCFVDERVRCDCCKTSIFDLHRSCPSCHYDLCLQCCWELRDGNLQGNKEEVIFEFNDPGPDYLHGGKRLKVKKAAEDPAPKEKQTHEWKSLDDGRIPCPPETMGGCGHGILELMHIKPLDSVPKLLEKAQKFLKMYKLEEDMSDIPKKWCTCSSDGGGQQLRKAASREISNDNYLYCPRAIDIKTGDLKHFQWHWSKGEPVIVSNVLETTLGLSWEPMVMWRAFRQITNLNHDRLLDVTAVNCLDWCEIEIYYMPNQLFYNMQVDISVHQFFIGYLEGKYDIEGWPYILKLKAWPISNLFEERLPRHGVEFITSLPFKEYTHPRDGYLNLAVKLPENSLKPDVGPKTYIAYGVAQELGRGDSVTKLHCDDSDVVNLLTHTASVTPNPEQLKEIDKLKQQHRAQDEMELFGLVGKTQLDVDNMKDVTFQKGTLGTCVDGSDLGDGGALWDIFRREDTPKLQEYLKKHFTEFRDVYCCPVQKVIHPLHDQTFYLTMEHKRKLKEEFGIEPWSFVQKLGDAVFIPAGCAHQVRNLKSCIKVALDFVSPENVGECIRLTDDFRLLPQNHRAKEDKLGVKKIAVHAVEAAVKDLENFVPKVPITENLQTSQNSEKGARGEEVGVDIDHDTASEEGDNSEHSNQESKVAHSSLSIDEFVAQLRAIRVTRDREVELMGKKVEIMEKRLDLKLKREEMKAKKLHHMHLNTLLLKDHLSPEDEDIKCHLWAMLYGKLL
The following text describes a protein:
Function:
Acetylates spermine and probably also other polyamines such as putrescine or spermidine. May regulate the levels of polyamines on chromosomal DNA, which would modify chromatin structure and affect transcription or replication. Also able to acetylate arylalkylamines such as tryptamine and serotonin in vitro.
Miscellaneous:
MISCELLANEOUS: Present with 8680 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MASSSSTLPLHMYIRPLIIEDLKQILNLESQGFPPNERASEEIISFRLINCPELCSGLFIREIEGKEVKKETLIGHIMGTKIPHEYITIESMGKLQVESSNHIGIHSVVIKPEYQKKNLATLLLTDYIQKLSNQEIGNKIVLIAHEPLIPFYERVGFKIIAENTNVAKDKNFAEQKWIDMERELIKEEYDN
The following text describes a protein:
Function:
May act as an inhibitor of TGF-beta signaling.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MCSRVPLLLPLLLLLALGPGVQGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDTGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPHLLLLDLSHNSLLALEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLQLDYADFGCPATTTTATVPTTRPVVREPTALSSSLAPTWLSPTEPATEAPSPPSTAPPTVGPVPQPQDCPPSTCLTGGTCHLGTRHHLACLCPEGFTGLYCESQMGQGTRPSPTPVTPRPPRSLTLGIEPVSPTSLRVGLQRYLQGSSVQLRSLRLTYRNLSGPDKRLVTLRLPASLAEYTVTQLRPNATYSVCVMPLGPGRVPEGEEACGEAHTPPAVHSNHAPVTQAREGNLPLLIAPALAAVLLAALAAVGAAYCVRRGRAMAAAAQDKGQVGPGAGPLELEGVKVPLEPGPKATEGGGEALPSGSECEVPLMGFPGPGLQSPLHAKPYI
The following text describes a protein:
Function:
Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MNRNSFLAATASLPLFILLAGCAPMHDTRQSLTQQTPSSHVDSSLPAALKNGWPDSQWWKAYHDAQLDALIDNAIQHSPDMQVAEQRIQLAEAQAKAVEAQDGPQLDFSADIERQRMSAEGLMGPFAITDPAAGTTGPWYTNGTFGLTAGWDLDLWGKNRAEVTARIGAVKAREAEQEQTRQLLASGVARLYWEWQTQAALKNVLMQIEHEQQNVVAVNRELYQHGITSSVEGVETDIDASKTQQQLNDVNGKMKVIEARLSALTNTQSAALKLRQVSLPAVESQLPSQLGYSLLARRADLQAAHWYIESSLSSIDAAKAAFYPDINLMAFLQQDALHLSDLFRHSAQQYGITGGLTLPIFDSGRLNANLDIAKAQSNLSIANYNKAVVDAVNDVARAASQVETLAQKNQHQQQIEHDAQRVVGLAQARFNAGIIAGSRVSEAKIPALREQCNGLLLQGQWLDASIQLTSALGGGYHS
The following text describes a protein:
Function:
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
Subcellular Localization:
Nucleus.
Sequence:
MVMEVVLGEASEVKNVVEAIELVETGVAKFVFSSRGLSLKAMDSRECAMMEILIPSDAFAHYRCDNVFSVGLSLDQMLQLLHRAHDSDIVSLTALEGQDHVTFTFQCPSNLSFSDHRMNLMMDIDNGPLLDIHEDAEYHAIVELPSPVFTTICCHIDSLSNIPIISIIVTRDTPILLVAAGDFGLCMHLPRGGTVIEMTQCVSLAFEIRYLNLVMAAMSLSDTLTIRLSMELPEAVFEYKIAAEKGYVRFHLPIAFNASYLLDD
The following text describes a protein:
Function:
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies.
Subcellular Localization:
Nucleus.
Sequence:
MRRKQTGTRERGRYREEEMTVVEEADDDKKRLLQIIDRDGEEEEEEEEPLDESSVKKMILTFEKRSYKNQELRIKFPDNPEKFMESELDLNDIIQEMHVVATMPDLYHLLVELNAVQSLLGLLGHDNTDVSIAVVDLLQELTDIDTLHESEEGAEVLIDALVDGQV
The following text describes a protein:
Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Reconstitution experiments show this subunit is required for basic activity.
Subcellular Localization:
Cytoplasm.
Domain:
Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
Sequence:
MFKLVRAKGIVRIPPEYFGQSVDEIAIKILRQEYQEKLIKDIGVVLGIVNAKASEEGFIIFGDGATYHEVEFDMLVYTPIIHEVIEGEVSQVDNYGVYVNMGPVDGLVHISQITDDNLKFDSNRGILIGEKSKKSIQKGDRVRAMIISASMSSGRLPRIALTMKQPYLGKIEWINQEIAKASK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MQKPYLLKAYSHSGRGRSSGGASRVWAGSAAHSPRPAPPGPSVHPRPRAGGRERRERCGGARGHNEAVRDRLEALSAAKEESPEAKEMVAAILNPESQEPVLFEDLAVYFSQEECVNLQPIQRDSCKDARWEMYKEMFPLGDGSMDENLNRESPENGTLQEISTGWGEEYSEWGKATEDNPGSPEWKRWALPLPRKKRFISLLVTIDNHIPLRDLSRCTDNLFPFEWDDSPTDQVVAPAHKCPECGKSFAKSSRLVSHRRIHTGEKPYECPACGKSFTQRSTLTTHEKTHQALKPHQCPRCGKAFRRVAHLLRHENIHTRARPHRCDRCGEGFSGNAKLLQHQKAHTGGRPFQCPTCGRCFGRNSDLVTHRRTHTGERPYRCPDCGKGFSQRSNLATHKRTHTGEKPYTCGHCGKIFRRSSHLARHEALHAGQSPHKCHDCRKGFLTDLELGRHRVTHSGLKLYPCLACDRSFSWKSDLAVHQRLHTGEKPFKCPTCEKSFRLSSHLVMHQRTHTGEKPYQCLDCKKSFSRCSDLIMHRRLHTGERPYRCSHCSKSFIRSSHLLRHQKIHRREEL
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MDPQDCTCAAGDSCSCAGSCKCKNCRCRSCRKSCCSCCPASCSNCAKGCVCKEPTSSKCSCCH
The following text describes a protein:
Function:
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus, nuclear pore complex.
Sequence:
MDDMMRAMDCLNMAATLRNAALASATCTGRTLGEDREPIWVEGSRKTPEPPLPEESPAPEPNNEIPLLPKIDFEPNISCFPDLQAINASIVRRELEEEGKRCVRQQLKAIRDKQDAMRLSRETQQRKEERQRDQLQQKALRERNESLLIQKADQMTAAQLEAQQREQLALRQQIDQKLHKLALEGVSRCQRRFNQKYEGIAKILLSLNPETVKVCAAQNTQLKELGQKFEQLVSSVKMGNCEMQSQFLCSIIKAEEFCKSLDALELDIIKQLAEFSEQIQQQLKMEAAKKLEDERQRQQQQEEERQKLEEQQKLEEQEKLRKEKEESAAKEKQQEAETAKADAANVPAPLEPKSQDVPPAATATSTSVHPDRLKFYNDILALYQSKVDAVKPLQTEESLKQYRTGCQRAINLPLNAISAVSPQHLAQNFDKLYSFFAGQPTKVMNGTITINDHPLARDYCMLLMAKKFVSQTETAICSNPQAAFPFASVIITFWKLLPDFGKVFLAYMYKESPFLVPYVIPQQQGQTPEQYLKTIGYRLTDKNELEKPDIYLKRQTGLARLYAAVIISQGRKAAGPDECFELNEGWLWLAHMVHVKPLPDISATLIMEILQTLGFELWRTYGKQFVKLLVYIQNIYMPQLAAYDEGGPKTRLEMLLAKFLRERQIAQAVGVLPPGFW
The following text describes a protein:
Function:
Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching; [CD40 ligand, soluble form]: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Cell surface. Secreted.
Sequence:
MINSHAHMSQQVSSSAMKTTMWIFTLFILAQIIGTSIFGVYFYKKLDKIEEEMSFSADYLVLRRIQKCMKGDSVDPTLLNCKEVLVKFRQLISEIIKTDTSGEKVEYRKATNQVSKNEVQGEEKNKLPKEESEQPVIAAHLVGEKSSNKEVLQWMEKGYSSMCKEVTYTNGKLKVEKAGIYYVYSQVSFCMNSQLSRAPFVQYVYLSKPQETDKLLLKGANTFITPTPDCALHSIQQGAVFALKKNDLLFVNVTDSSRVNYSPGLTYFGMFKL
The following text describes a protein:
Function:
Lignin degradation and detoxification of lignin-derived products.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MVTVNGKFPGPRIVAREGDRLEIEVINNVQNNISIHWHGIRQIRSGWADGPAYVTQCPIQIGQKYVYNFTIIGQRGTFWWHAHISWLRSTLYGPIIILPKKNNPYPFTKPYKEVPIIFGEWFNGDTEAIISQALQTGGGPNVSDAYTINGLPGPLYNCSTKDTFKLKVKPGKTYLLRLINAALNDELFFSIANHTLQVIDADGVYVKPFETNTIIITPGQTHNVLLKTKPHFPNAKFYMLARPYVTGPGTFDNSTVAGILEYESKSKHHLKNLPIFKPSLPSLNDTIFVTNFTSKLRSLATPQFPANVPLNVDRHLFFTIGLGTSPCDQNKTCQGPNGTKFSASINNVSFILPTTNALLQSHFFGQSKGVYKPDFPYSPLHWFNYTGNPPNNTLVNNDTKLMVLPFNTSVELVMQDTSILGLESHPLHLHGFNFFVVGQGFGNYDPNKDPSNFNLVDPIERNTVGVPSGGWVAIRFLADNPGEWWKADTEKIINQALQTGGPPNISDAYTINGLPGLLYNCSAKDTFKLKVKPGKTYLLRVVNAALNDELFFSIANHNLTVVEVDAVYVKPFNTNIILITPGQTTNILLKTKHFHPNATFLMSARPYATGPASFDNSTTTGILEYHKPSNNTKKSNIFPLLKPKLPIFNDTTFATSFVKKIRSLANAKFPANVPKKVDKQFFFTVGLGLNPCPKNQTCQGPNNTKLAASVNNVSFVQPNVALLQSHYFNQSKGVYTTDFPVNPPFKFNYTGNPPNNSFVTSGTKVVMLPFNTSVELVMQDTSIISAESHPLHLHGFNFFVVGQGFGNYNSSNDPANFNLVDPAERNTVGVPSGGWVAIRFLADNPGVWFMHCHLEVHTSWGLKMVWMVNDGKSPKQKLPPPPADLPKC
The following text describes a protein:
Function:
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Sequence:
MGFLSKLIAKLKPKKSVAKQLKEEVEKQSLFQTNNKTYYQGLKKSATTFAKTINELSKRYVNVDEQFKENLFEGLVLLDVGYHAANKICDAIIEQIKLNRITDFQLIKELIIDQIIVYYIQDKLFDTDLIVKPNFTNVYLFVGVNGVGKTTTLAKIADFFIKQNKRVLLVAGDTFRAGAIEQLNQWAKLLNCDIVLPNPKEQTPAVIFRGVKKGIDDKYDFVLCDTSGRLQNKLNLMNELQKIYQIIQKVSGSEPSETLLVLDGTVGQTGLSQAKVFNEFSKLTGIVLTKMDGSAKGGIILAIKDMFNLPVKLIGFGEKTSDLAIFDLEKYVLGLLNNLNLDNKEN
The following text describes a protein:
Function:
RNA-binding protein involved in group II intron splicing. Binds specific group II introns and promotes their splicing (e.g. rpl2 and ccmFC).
Subcellular Localization:
Mitochondrion.
Sequence:
MLSIRRHAKTVASSCTNLTQKRTYVDVYMKWKRDPYFDNIEHILRSSQLKSVVSLKNCIVQEPNRCIPISAISKKTRQFDVSTKIAHFLRKFPSIFEEFVGPEYNLPWFRLTPEATELDRQERVVYQTSADDLRDRLKKLILMSKDNVLPLSIVQGMKWYLGLPDDYLQFPDMNLDSSFRFVDMEDGVKGLAVDYNGGDKVLSVLQKNAMKKRRGEVSLEEIEFPLFPSKGCRLRVKIEDWLMEFQKLPYVSPYDDYSCLDPSSDIAEKRVVGFLHELLCLFVEHSAERKKLLCLKKHFGLPQKVHKAFERHPQIFYLSMKNKTCTAILREPYRDKASVETHPVLGVRKKYIQLMKNSELILKSRRNSFGFRDEGVVDKDLDLDFEG
The following text describes a protein:
Function:
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MSDCRLSLAEGTMNWHLPLFLLASVTLPSICSHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITRSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
XWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFAHWFPLFSGYTLNDTWAKIHFTIMFVGVNMTFFPQHF
The following text describes a protein:
Function:
Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle.
Subcellular Localization:
Apical cell membrane.
Sequence:
MAALNSVLKLLLLQLVGLQVLLSPSFAVSSPKGCTFPETTNMTTNFSMKADSNVYKTNKTYTVTFSGNENLHSVILQAVDKDNKSVGQWQNPDQMCNNSVIYQMKNSSRSIFQANWTSPNCSDITEVEIRAFTFYFNNGATFSSLKLDRKVPTPSLTTAKSSARKAFTCSVIDIIQLLFVYFTSKLIS
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC22.
Sequence:
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAADDDELFTTGVSWNVS
The following text describes a protein:
Function:
Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MVPPVWTLLLLVGAALFRKEKPPDQKLVVRSSRDNYVLTQCDFEDDAKPLCDWSQVSADNGDWVRASRPSPTGSTGAPGGYPNGEGSYLHMESNSFHHGGVARLLSPYLWEQGPLCVHFAYHMFGLSWGAQLRLLLLSGEEGRRPDVLWKHWNTQRPSWMLTTVTVPAGFTLPTRLMFEGTRGSTAYLDIALDALSIRWGSCNRVCMMQTCSFDIPNDLCDWTWIPTWTQKKGSSGKPGVGPDGDFSSPGSGRYMLLDPKNARPGQKAVLLSPVSLSSGCLSFSFHYILWGQSPGASLHIYASVLGQPGPNWQAVSVNYTAVGRIQVQRSKGSGPCTCGDGVSPCWPGCWHVLCRLLILPVPFLCLGGHYIYLEADKFSQAGQSVRLVSRPFCAPGDICVEFAYHMYGLGEGTMLELLLGSPAGSPPIPLWKRVGSQRPYWQNTSITVPSGHQQPMQLIFKAIQGSNTASVVAMGFILINPGTCPVKVLPELPPVSPVSSTGPSEITGLTENPTISTKKPTVSIEKPSVTTEKPTVPKEKPTISTEKPTIPTEKPTIPSEKPNIPSEKPTIPSEKPTILTEKPTIPSEKPTISTEKPTTPTEDIPTEKPTISMEETIISTEKPTIPTEKPTISTEKPTIPTEKPTISPEKLTIPTEKPTIPTEKPTISPEDIPMEKPTLPTEETTTSKSTISPEKPTISMEKPTTPTEKPTIPIEETTISTEKLTIPTEKPTISPEKPTISTEKPTIPTEKPTIPTEETTISTEKLTIPTEKPTISTEKPTIPTEKLTIPTEKPTIPTEKPTIPTEKLTALRPPHPSPTATGLAALVMSPHAPSAPMTSVILGTTTTSRSSTERCPPNARYESCACPASCKSPRPSCGPLCRGGCVCNPGFLFSDNHCIQASSCNCFYNNDYYEPGAEWFSPNCTEHCRCWPGSRVECQISQCGTHTVCQLKNGQYGCHPYAGTATCLVYGDPHYVTFDGRHFGFMGKCTYLLAQPCGNSTDPFFRVTAKNEEQGQEGVSCLSKVYVTLPESTVTLLKGRHTLVGGQRVTLPAIPSKGVFLGASGLFVELQTEFGLRQLYVTVSSTYSGKLCGLCGNYDGNSDNDHLKSDGSPAGDKEELGNSWQTDQDEDQECQKYQVVNSPSCDSSLQSTMSGPGFCGRLVDTRGPFETCLLHVKATSFFDSCVLDMCGFQGLQHLLCTHMSTMTTTCQDAGHAVKPWREPHFSMACPPNSKYSLCAKPCPDTCHSGFSGMFCSDRCVEACECNPGFVLSGLECVPRSQCGCLHSAGSYFKVGERWYKPGCKELCVCESNNRIRCQPWRCRAQEFCSQQDGIYGCHAQGAATCTASGDPHYLTFDGALHHFMGTCTYVLTRTCWSRSQDSYFVVSATNENCGGNLEVSYIKAVHVTVFDLSISLLRGCKVMLNGHWVALPVWLAQGRVTIRLSSNFVLLYTNFGLQVHYDGSHLVEVTVPSSYGGQLCGLCGNYNNNSLDDNLRPDRKPAGDSVQLGAAWKLPESSEPGCFLVGGKPSSCQENGMADAWNKNCAILINPQGLNSRAQLLMPQGLGAGHATPLFLMLSFSLAMRCPPGSSYSPCGSPCPATCSSINNPRDCPKALPCAESCECQKGHILSGTSCVPLGQCGCTDPEGSYHPVGERWYTENTCTRLCTCSIHNNITCFQSTCKPNQMCWALDGLLRCRASGRRTTVMGGLHSPEAHSPNSPTDSLGTIPDHCNLCLLGSSDSPASAFRVAGITGAHHHAWIIFLYFYPCPPWPPVTLSTDPLSPLPTALECPAYSSYTNCLPSCSPSCWDLDGRCEGAKVPSACAEGCICQPGYVLSEDKCVPRTQCGCKDAHGGSIPLGKSWVSSGCTEKCVCTGGAIQCGDFRCPSGSHCQLSSDNSYSNCVSDKSEQCSVYGDPRYLTFDGFSYRFQGRMTYILIKTVDVLPEGVEPLLVEGRNKMDPPRSSIFLQEVITTVYGYKVQLQAGLELVVNNQKMAVPYRPNEHLRVTLRGQRLYLVTDFELVVSFGGRKNAVISLPSMYEGLVRGLCGNYDKNRKNDMMLPSGALTQNLNTFGNSWEVKIEDALLRFPRAIPAEEEGQGAELGLRTGLHVSECRPEQLASNSTQACRVLADPQGPFAACHQTVAPEPFQEHCVLDLCSAQDPREQEELRCQVLSGHGVSSRYHVSELYDTLPSVLCQPGGPRGLRRSLRGRLRQHPRLCLQRHPEPPPGAKESQTRDGTGTSFVTEDCSPRCTCASSQILLCEPFSCRVGEVCTLGNHTRGCFPESPCPQNPCQNDGQCQEQGATFTCECEVGYWGDLCTEPRDAPPPRKPASNLVAVLLGLLVPVVVVVLAVTRECIYRTRRKREKTQEGDRLARLVDTDTVLDCAC
The following text describes a protein:
Function:
Putative transcription activator involved in regulating light control of development.
Subcellular Localization:
Nucleus.
Sequence:
MYTELYLVSIGFLILEGDNLSNLFPIEEFQVFGLSIGAKKFFVILVAVIILPTIWLDNLSFLSYVSASGVFASGVIILSISWTATFDGIGIHQKELQENLFPSFEDHDRLNERVVTVDIRSTSFSCSCRMFENRGLGGYVQYHFLKILEFLGGYVHYHFLKTIPEQYVLKRWTRDVRPSVDKLKSIINVGTEDTTQAQRYQQICVVTVQLSTQELILSKGIRPDPSSVTPSKSSKVAAVDEPSAGADGFPEPEIIDYNPKDFDFGKKKSFSFRDQVK
The following text describes a protein:
Function:
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1. May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MADEEGGGDRNINNNMGNQLELLPENEEEDEAEMETEDHDGDGAAKPNIINFDPSLPTSHAYLGMDMEEFHGRTVHDEDSCQMIPVLPHTAVMLIPGQTLPLQLFRAQEVSLMRNLIQKDRTFAVLAYSDAGDRQAEFGTTAEIYAYREEQEYGIETVKVKAVGRQRFKVHEIRTQADGIRQAKVQILPERVLPPTLCAVQLNSQSRLHMHTASRPPAKQCRQVQRWWDKYQKYILMLYYNRMRPSCSITLGEISHLASHLSCFARKFHCANLTSWPAWVYSLYDSEILMDRVKRQLHEWDENLKDESLPSNAIDFSYRVAACLPIDDALRIQLLKIGSAIQRLRCELDIMDRCTSLCCKQCHDTEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKANNLNLTGRPSTLHSWFPGYAWTIAQCRTCGSHMGWKFTATKKDMSPQKFWGLTRSAMLPRIPKSEDEDEEEGSRQLCL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MYEQKLAIGIVNEAFGDDVSKVFEFLVHRGKSSFKIINQALQGTVGLKRIKQCLLVLIQHNLATFEEFLIPLGKDEQESLTPGDPFPSDSVYEAIIVNAIHRLRFPKFINFIKVSKGDEAAFILEELIDHGRLPMDMILKQASAYSRAADSFEDTEEITKRFEDIFTKLIMDQFIMRAPRPRPINDQDQSNAINKEAKKTKDSQSSSNKKEADPFALPAGFSSNGPLSNDNLPNLPLDILTGGGATNNGSSAPLHPNGNKTAKKNGPKVQLSTTTTTTTSSKSTSKTTGKKRKNIVEEDDEANESPDVLMISESAQLNVHDIGDSNIQPNKKSKLDVYTVVSPQEQQQRIINDETRVLWTINYEQFVTEFKLKACYDFVVEKNNQQSGLLFNAMVKLCKRSIRSNSDTLTSCVYGENALEEYNRDLDPSKRMDKLQFEKYLSVMQASRPSMVTKMQTKSKQSSSSELGAYQVNVGNIIAVIKQKMVESIIKQKFGDNGLRVFKLLLIKNLLEPKQIADLAMIPIKECKALLFNMMQKNIIRLQEVPRSSDHFANRTFYLFFVDLPSIIRDFTEDIFKAIYNTRERLNSELAPHKDMLDKMSELDEESPVTEDQTKIFKKTDRITQTLLTVILNLDNDLLHLYSF
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin IX (hemin).
Sequence:
MGDNIVLYYFDARGKAELIRLIFAYLGIEYTDKRFGVNGDAFVEFKNFKKEKDTPFEQVPILQIGDLILAQSQAIVRYLSKKYNICGESELNEFYADMIFCGVQDIHYKFNNTNLFKQNETTFLNEDLPKWSGYFEKLLKKNHTNNNNDKYYFVGNNLTYADLAVFNLYDDIETKYPSSLKNFPLLKAHNEFISNLPNIKNYITNRKESVY
The following text describes a protein:
Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MVERKLTGAHYGLRDWVMQRATAVIMLIYTVALLVVLFSLPKEYSAWQAFFSQTWVKVFTQVSFIAVFLHAWVGIRDLWMDYIKPFGVRLFLQVATIVWLVGCLVYSVKVIWG
The following text describes a protein:
Function:
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDLTDDSPDGEVKIHKKDFHHPYTPYPIQEKFMQTVYDVLEQGKIGILESPTGTGKSLSLICGSLTWLRDFKRKEFEGILNDGFENSEEPEWMIEAAKVRKKRELIGRREEMERKLGRIRERERCERDRMSGNGNGNMRGGKRRKVGGDGEGDLVGGSNGSNEDEFLLEDWESDGEIGGSGKKKTGDEAIFSKETLELKKSIGMWKFPSPMPLEEFPSKTTEKDKDNLHEHLRHLPLGSRKNLCINPKVNKLNSVTAINERCAELQQSSTPKEHKCPHLPNKDNKPLVSTFRDHALATIRDIEDMGALGKEISICPYYASRSAIKPAEIVTLPYPLLLQKSAREALGISLKGHVVIIDEAHNLMDAIAGIYGTEMSLKELKLAKEMLGNYFMKFAKRLKGKNRIYVAQAIRVVDSLMGYLMKRLEGTEIDGVVDQKELLAGKGADQIDLFKLIRYLQESKLARKVESYTEHTRNIKQASTIPHNNKETPKSTTPILHTLTSLLLALTHPTTEGQLFFLKSTSTSPSPSPDLITLKFQLLNPAPHFESIVSSARAIILAGGTMSPFSDYTSILFPSIPSHKITTLSCGHVIPKTHLFASTVSRGPTGIPFKWTFANRGNTDMMDELGRVLLNVCTIVPDGVVVFFPSYNFLSTILYRFSIPSSGTGSATATATGTEKGKGKTILERLSEKKPIFQESKEESVETILAAYAKSIAEGKGALLFSVVGGKLSEGINFSDALGRCVMIVGLPFPNMHTAEWKRRLRFIEESAVERLTSFYQEKESNNKDGNGNEEEGNGKKKENREKIQRDQILQQAKGEARDYFENVCMRAVNQCVGRAIRHRGDWAGILLLDERYKGERVVGKLAGWIREGVLRGEGMGMGDAGGFGRLMGGLGRFCRGRREVL
The following text describes a protein:
Function:
Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MGWIRGRRPRHNLEMSEFHNFKLGLAKSDFSTRCQKQRCPVIKSKCRENASPLFFCCFIAVAMGIRFIIMVTIWSAVFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFNESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSIPNTYICMQRTV