lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Gating-modifier toxin that potently inhibits inactivation of the mammalian Nav1.1/SCN1A sodium channel (EC(50)=38 nM). Also moderately inhibits inactivation of Nav1.2/SCN2A (EC(50)=236 nM) and Nav1.3/SCN3A (EC(50)=220 nM) when the channels are expressed in oocytes without the beta-1 auxiliary subunit. Does not inhibit inactivation of Nav1.2/SCN2A when the channel is coexpressed with the beta-1 auxiliary subunit. When tested on Nav1.1/SCN1A channel, it enhances peak current amplitude and potently delays channel inactivation in a dose-dependent manner, leading to a large sustained current. It has no effect on the voltage-dependence of steady-state activation, and induces a depolarizing shift in the voltage dependence of inactivation. In addition, it does not modify the recovery from fast inactivation in Nav1.1/SCN1A. The binding affinity and subtype selectivity of the toxin towards Nav1.1/SCN1A channel is determined by residues within both the S1-S2 and S3-S4 loops of the domain IV voltage sensor of the channel. This toxin also weakly inhibits several subtypes of voltage-gated potassium channels. It moderately blocks Kv2.1/KCNB1 (23% inhibition at 100 nM), Kv2.2/KCNB2 (19.7% at 100 nM and 51% at 300 nM), Kv4.1/KCND1 (IC(50)=280 nM), Kv4.2/KCND2 (39% at 300 nM) and Kv4.3/KCND3 (43% at 300 nM). In vivo, intracerebroventricular injection into mice elicits convulsions, spasms, tremors and rapid death. When injected into mouse hindpaw, the toxin elicits an immediate and robust response to pain. However, intraplantar injection of toxin does not cause neurogenic inflammation or alter sensitivity to heat, indicative of a modality-specific effect on mechanosensitive neurons. In Dravet syndrome mice model, intracerebroventricular infusion of this peptide rescues mice from seizures and premature death.
Miscellaneous:
MISCELLANEOUS: Shows poor stability in cerebrospinal fluid and moderate stability in human serum. Half-life of the toxin is about 1.7 hour in cerebrospinal fluid. Half-life of the native toxin is about 10 hours in human serum; MISCELLANEOUS: Negative results: does not inhibit Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.7/SCN9A, and Nav1.8/SCN10A at concentrations up to 50 nM or 1 uM. Does not inhibit Nav1.2/SCN2A at concentrations up to 50 nM. Has no or very weak effect on Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.3/KCNA3, Kv1.4/KCNA4, Kv1.5/KCNA5, Kv1.6/KCNA6 and Kv3.4/KCNC4. Does not show significant effects on Kv1.7/KCNQ1, Kv10.1/KCNH1/EAG1, Kv11.1/KCNH2/ERG1, KCa1.1/KCNMA1, KCa2.1/KCNN1 and KCa2.3/KCNN3.
Subcellular Localization:
Secreted.
Domain:
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Sequence:
ECRYLFGGCSSTSDCCKHLSCRSDWKYCAWDGTFS
The following text describes a protein:
Function:
omega(3) desaturase that uses both 18-carbon and 20-carbon n-6 polyunsaturated fatty acids as substrates.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence:
MAPPHVVDEQVRRRIVVEDEIKSKKQFERNYVPMDFTIKEIRDAIPAHLFIRDTTKSILHVVKDLVTIAIVFYCATFIETLPSLALRVPAWITYWIIQGTVMVGPWILAHECGHGAFSDSKTINTIFGWVLHSALLVPYQAWAMSHSKHHKGTGSMTKDVVFIPATRSYKGLPALEKPAVEEEVSEQEHHHHEESIFAETPIYTLGALLFVLTFGWPLYLIVNFSGHEAPHWVNHFQTVAPLYEPHQRKNIFYSNCGIVAMGSILTYLSMVFSPLTVFMYYGIPYLGVNAWIVCITYLQHTDPKVPHFRDNEWNFQRGAACTIDRSFGTIVNHLHHHIGDSHQCHHMFSQMPFYNAVEATKYLKAKLGKYYIFDDTPIAKALYRNWRECKFVEDEGDVVFYKH
The following text describes a protein:
Function:
Iron transporter (By similarity). Required for parasite development during the blood stages. Required for apicoplast biogenesis. Required for mitochondrial polarization.
Miscellaneous:
MISCELLANEOUS: Exogenous supplementation with non-toxic concentrations of iron or other metals does not rescue parasites with stringent gene knockout. Culture supplementation with Fe(2+), but not other metals, nearly fully rescues parasites with partial gene knockout.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MEKDFTERSTKGQRKLANGVVENIESKLKNHLDNNNVINKSVNYEDVMCSNVKLSVHDDEYDIKNIKKDVCNLSKLSEERLSNNISLKDNNKVVKNPEIDTKTARQQYKKRLNSTQSTMNIEGNINNEKDDIIEDYDDGLIRNMDYEMSIVKNKRNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNVDNRKRNKNEECYDESYCISDNLDEITSYRNKLSLYNKLRMCFNYFGPGWIVAIAYLDPGNLCSNLNVGLIRSPDPTLEKDYSGYYLLWIMVYGHMLGFIFQVLSMRLGHVTGLDLASLCSKEFDRTTSTIIYVLVQIAIWGAHIQAIIGTFIALNLIFGISVKVAIFYTLFEAIIYSFLENKSLGLLENVLSFLVGILAVSFFVNVFMTPINFKELAISILYPRIPKGKEIDALALLGSIISAHIFYLHTNLTAKKKSVICNDLSLRRYNTLGTIESGGSLFLSCLTNCIIVLTFAEVNLKSFERRDQYNLFTAYEVMRKSFGKISMYIWSFGLLSSGNNSSFMCEYASKSVVEGFLNKKINTFVRVFTFRLMLFSLLYMFLTLNKYTLDQLTNFINVIQVLLLPMATIPLYRFSIHENVLGEFRLKKFPKFAVFLIIIAIIISNVLLTFLDFVHKETSLITIFFLVIFSFLYFGFIIYFFNIPIKKNYIQRN
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 1920 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MKIQTNAVNVLQRTSAYLKSGLLKETPAWYNVVASIPPSTKFTREPRFKNPSNGHIIGKLVDVTEQPHANNKGLYKTRPNSSDKRVGVKRLYRPPKLTYVEDRLRSLFYKQHPWELSRPKILVENEIGDENYDWSHMLQIGRPLDGESVIQRTMYLIKTKQYGDMVEAYDHARYEFYALRMQEETEQQVALEEAEMFGSLFGVSAIEHGIQKEQEVLDVWEKKVVEETELMAARTSNPAGSWKDDTTLNTAQEEESTTSENLHF
The following text describes a protein:
Function:
Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasmic vesicle, secretory vesicle, acrosome.
Sequence:
MADADGIWSQHGGMDGLPPSDPPEISFGAPEVFQVGTSDSPASELPDSALGYGVPYIPDDDDDSQEEEGPELSPDGILDEETVAQGLSNLGKAAGGTSQVFLHLTLPGYNLADISLLQDYVHLQRLEMPYNQITDLSALSCMTHLLYLDVSHNELRDLLNFDPPINLKEVDYSYNKLEAIQDLSEHTALTKLTLDNNNITEITGLSNCRQLRYLSIAHNNLQKISGLDHLKIKYLSLRGNNIKRIENLETLVYLQVLNLSGNAISSMAGLEGHNYLESVDLDDNEVSNIAEVQYLVDLRLLTDLNLMRNPIQGLPDYRLSILYKLQQLSTLDRKRAEVEEKVQAINMFNPPQEVIAAQDHIRNVVYSFLTASRVYDSTLPSIETPYPMLVLTGPQGSGKRDLALRLVQDFPDYFGYGISHTTRPPKTGEEDNKDYHFVSMERFENLIRQGKFIQTCQYAGHLYGLTMDAVEAVAKEGLACVVHMELEGVMTLKNTYFEPRYVLIIPATRQYLAERLSSREGIHQDEVTYNITRWNTYVDTNQTSPGFFDMAIDSDDLGQAYTNLRKLVMDYLGISDAASSETSTIDGDSRSQSAIEAKDGTMTGVTSTNSATRATKWSKPTGSISMDMEMGGGAARTYSGQHRKMEPKKTPVEEASYARRSAAAKAAIITGIVPNPYQQLMQRPPGTAPSNTLDQDGLGDHDQQRPATAPMDATTSFLSMQANTSQALQGSMDSSSDESEESASLSDLSSARQFSAAGSSDTSEQGEGGYAERVEGLDLAALENALSDQGSLTSPPAAPRPGSAGSGQMSLPGSRPGSAREPVTSRPGSNLKPVLPPIPSYRGEKQDKSLPDF
The following text describes a protein:
Function:
Mediates the Na(+)- and Cl(-)-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Note=Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi.
Sequence:
MEKARPQWGHPLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWGFWYLFHSFQDPLPWSVCPLNSNHTGYDEECEKASSTQYFWYRKTLNISPSIQENGGVQWEPALCLTLAWLMVYLCILRGTESTGKVVYFTASMPYCVLIIYLVRGLTLHGATNGLMYMFTPKMEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSIINSSTSIFASIVTFSIYGFKATFNYENCLNKVILLLTNSFDLEDGFLTVSNLEEVKNYLASTYPNKYSEVFPHIRNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKVISSYLPKEAISGLVCLINCAVGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLKRFESDLRAMTGRTLSWYWKVMWAFVSPLLIVGLFIFYLSDYILTGTLQYQAWDATQGQLVTKDYPPHALAVIGLLVASSTMCIPLVALGTFIRNRLKRGGSAPVA
The following text describes a protein:
Function:
Has antimicrobial activity.
Subcellular Localization:
Secreted.
Sequence:
MRTLGLLLALLFLAAQTPAQLMGEEAEEATGRPEATEAQEAAAALMAARAADRHVTDPEQQRIITCSCRTFCFLGERISGRCYQSVFIYRLCCRG
The following text describes a protein:
Function:
Potassium transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MIIKHSNRSLPSLLVSVVEFFSLSNQCVPERQTGSLNLIEMEKTMNEESEVKGGMWALQQKFDQPMDEEASRLKHMNTETKCSTLLLVRLAFQSLGVVYGDLGTSPLYVFYNTFPKGINDTEDVVGALSLIIYSLTLVPLIKYVFIVCRASDNGQGGTFALYSLLCRHAKISTIPNQHRTDEKLTTYIYTPTHENSFPEKTKKWLEAHALKKNALLVLVLVGTCMVIGDGILTPAISVLSASSGIKVTHPGMDNDFIVVVAVFILIGLFCLQHHGPDKVGWLFAPIVLLWFILIGGIGIYNILKHDKTVLRAFSPLHIYWYFKRRGKDGWTSLGGIMLSITGTEALFADLAHYPLSAIQIAFTTVVFPCLLLAYCGQAAYLMKNKEQVFDAFYHSIPEAVYWPMFVIATLSAIVASQASISATFSIINQACALGCFPRVKVVHTSRKFLGQIYIPDINWALMILCILVTTGFKNQTQIGNAYGTAVVIVMLVTTFLMILIMLLVWHCNWFLVFIMTFLSLIVECTYFSAVLIKIDQGAWVPLAIAAVFLLIMYVWHYGTFASPESDSCTPSSQAASHGSSHISSRIFRRSIRWLFSSALNLSRFIPSRKTNGFWSNGSDRRTTIFSGVSRDQKKDDEFEKKLIDSIFLFVKLESLMDGSSDSDEYSLYEQDVSGLSDKNTFSSVVDILISDDDTVSETGTETASSHGGGGREEIEFLTRCRDAGVVHILGNTVVKARRDSGCYKKICIDYLYAFLRKICRENSVIFNVPHESLLNVGQVFFV
The following text describes a protein:
Function:
Transcription factor that represses the expression of HEM13, COX5B, ANB1, CYC7 or AAC3 (hypoxic function). Binds to the DNA sequence 5'-RRRTAACAAGAG-3'.
Miscellaneous:
MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MNPKSSTPKIPRPKNAFILFRQHYHRILIDEWTAQGVEIPHNSNISKIIGTKWKGLQPEDKAHWENLAEKEKLEHERKYPEYKYKPVRKSKKKQLLLKEIEQQQQQQQKEQQQQKQSQPQLQQPFNNNIVLMKRAHSLSPSSSVSSSNSYQFQLNNDLKRLPIPSVNTSNYMVSRSLSGLPLTHDKTARDLPQLSSQLNSIPYYSAPHDPSTRHHYLNVAQAQPRANSTPQLPFISSIINNSSQTPVTTTTTSTTTATSSPGKFSSSPNSSVLENNRLNSINNSNQYLPPPLLPSLQDFQLDQYQQLKQMGPTYIVKPLSHTRNNLLSTTTPTHHHIPHIPNQNIPLHQIINSSNTEVTAKTSLVSPK
The following text describes a protein:
Function:
Activator of asnA transcription; autogenous regulator of its own transcription; and repressor of the expression of gidA at a post-transcriptional level.
Sequence:
MENYLIDNLDRGILEALMGNARTAYAELAKQFGVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSAKDYPSALAKLESLDEVTEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLIVLQNPIMRTIKP
The following text describes a protein:
Function:
Catalyses the transfer of galactose onto proteins or lipids.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MNWMRANPQMLLIVVMMSGSFIILAHFSLFRNKVIQRFMHASRGNIQKQVVIEESPYIKRNKIMNRESLARILRLNFEQKNETKPTSRKCHVAYAKLKGYISLHLMTEETNQTTSSGLTWPPTLKYLDFIYKDLEHGGVYKGPKECKCATNFAIIVPFRDREQHLRFFLFYIHPLLQRQRTCYTIIVVEQDDDKTFNKGKMMNSGFLYANSIGDFDCYIFHDVDMIAENDRNIYQCKEKKVAHLVWQMDKYDYEIPYYDYIGGVLAFTKEQFITVNGFSTMYEGWGGEDDDMMKRIWAKGYELWRPRKKNIARFKMIHHNHDKRNPRIDDYLMQDLLFSAISRQDSDGLNSLHTVRTDVIKYPSHTRVKVRS
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MWINKIGNKSASFINHKHFHPGNIKNLERVWLAEENEKKRKEEEEKYLKKREEQYKLYELKKQLRKNEEENKNDVHNILYDINNELKKENSFKKKILHNSISNETTPNENIVNKILIRSKYDEDIFLKNHRSIYGSYYDKEKNKWGFKCCTNIDKNSKCTNNTNCSYNLNNNLIKKDLTKSKNKKKKKKKLIVDNSITAVLNKI
The following text describes a protein:
Function:
Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells. Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner. Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis. Negatively regulates BAX promoter activity in the absence of TP53. Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif. Involved in TNFSF11-mediated terminal osteoclast differentiation (By similarity).
Subcellular Localization:
Nucleus. Nucleus speckle. Cytoplasm.
Domain:
The N-terminal transcriptional activation region is sufficient to induce transcriptional activity; The POU-specific domain and POU homeodomain regions are necessary for DNA-binding activity and transcriptional repression; The polyhistidine motif acts as a targeting signal to nuclear speckles.
Sequence:
MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI
The following text describes a protein:
Function:
Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development (By similarity). The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (By similarity). They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation (By similarity). KHDC3 ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process (By similarity). Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function (By similarity). As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity). Regulates homologous recombination-mediated DNA repair via recruitment of RAD51 to sites of DNA double-strand breaks, and sustainment of PARP1 activity, which in turn modulates downstream ATM or ATR activation. Activation of ATM or ATR in response to DNA double-strand breaks may be cell-type specific (By similarity). Its role in DNA double-strand break repair is independent of its role in restarting stalled replication forks (By similarity). Promotes neural stem cell neurogenesis and neuronal differentiation in the hippocampus (By similarity). May regulate normal development of learning, memory and anxiety (By similarity). Capable of binding RNA (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cell cortex. Nucleus. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome. Note=Core component of cytoplasmic lattices in oocytes (By similarity). Expressed in the subcortex of oocytes (By similarity). Located throughout the cell cortex of ovulated eggs in a complex with NLRP5 (By similarity). After fertilization, restricted to the apical cortex and excluded from regions of cell-cell contact (By similarity). Localized to centrosomes during interphase and mitosis (By similarity). Localizes to sites of DNA double-strand break repair.
Domain:
Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA.
Sequence:
MDAPRRFPTLVQLMQPKAMPVEVLGHLPKRFSWFHSEFLKNPKVVRLEVWLVEKIFGRGGERIPHVQGMSQILIHVNRLDPNGEAEILVFGRPSYQEDTIKMIMNLADYHRQLQAKGSGKALAQDVATQKAETQRSSIEVREAGTQRSVEVREAGTQRSVEVQEVGTQGSPVEVQEAGTQQSLQAANKSGTQRSPEAASKAVTQRFREDARDPVTRL
The following text describes a protein:
Function:
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity).
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein.
Sequence:
MDQAELSIEQVLKRDIPWETYMNTKLVSAKGLQLLRRYDKKPESARAQLLDEDGPAYVHLFVSILRDIFKEETVEYVLALIYEMLSANPTRARLFHDESLANEDTYEPFLRLLWKGNWFIQEKSCKILAWIISARPKAGNAVIGNGIDDVLKGLVEWLCAQLKQPSHPTRGVPIAISCLSSLLKEPVVRSSFVQADGVKLLVPLISPASTQQSIQLLYETCLCIWLLSYYEPAIEYLATSRTMQRLTEVVKHSTKEKVVRVVILTFRNLLPKGTFGAQMVDLGLPHIIHSLKTQAWSDEDLLDALNQLEEGLKDKIKKLSSFDKYKQEVLLGHLDWNPMHKETNFWRENVTCFEENDFQILRVLLTILDTSSDPRSLAVACFDISQFIQYHAAGRVIVADLKAKERVMKLINHENAEVTKNAILCIQRLLLGAKYASFLQA
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MAPGMNTRLSMLSSQQQRSSKPGGLVGLSDTMAGLSVGQSRPSDTRRTSTINGNGSARMSLGRQSMGFGGRPSLSSVSLSGQASSITKDPRPLKEKQWQTKAIKQLVSFLAQTGCPVPISAKKLTAPSSKDFADVFKFLYRKLEPNHEFKSKIEEELLSLLRTLRYPFAEQINKSQLFSIGSPHAWPTFLGILHWLMEEIMCCIEFDEQSQIDDNNDTMGDSRQPEKIFHDYVIRTYIAFLEGSDDFDAIDRELMGSFDRKNEVTIRDVERLRREHQALEEEMAVLTQGESPLEALTRENGILESDKEKFRTYITHVEGKEQKLNENLLSLKQELDIQAEEIACLTNEKTELQQTVDAQDISPADVDRMNAERDQLALSLQTVSTKLETANKIVWEKEIALQKRMDQLEKVVQDYNSQAFKLGLIGSRSADLAPLAKELELYIQADTQDHMVSVDLKGVVKTTLQRLKERYNAALHKAQDDMLELQETLDQLVWTQTRDEEELLSMQSRITFLNHRYNEEKEHVTLTTTAMNDDIEHFERQIQKLKVESNAMMFAVQQKGQTVTIEYEELSRKYTEQKEKALNQLIRGLQDVFGMQTGVAAAIEELSRQANEALTEATNYTSNLISSEDTVIEV
The following text describes a protein:
Function:
Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLSFLIRRLLQTIPTVLAVVMLVFVLFSVVPGSIVSTMSDDSDPQVEARMKKQLGLDEPVYLRFGSYIAKLATGDFGTSFRTREPVTTMIAKRMGPTLQLIFASMAFAVAIGVPLGFVAALRPGGVVDSAAMVVAVSGLSMAKFWLGLLLMYLFALKLGWLPSFGYGDGGLKNLILPAVTLGVSPMALLARTTRAAVLEIMHADFVRTARSKGMSETRVVKWHVMRNALVLILTTMGLQFGALMGQAVVVEKLFSWPGIGSLLVDSVLQRDIPAVQGSILVVVLFFLAINLLIDLLYGVIDPRIRYA
The following text describes a protein:
Function:
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEQDQHQITQVNSFVSIVSGVFGVVIKNGLYQALSSQLEAPFRQIPANMLGCFLVGFFTNSNTSLQVVFDSVTSLAFWNQAMATSALNGNWFFALSSFITGLELAYISYKIGLDTGLMFHDAFGSSTVAPEKKKKKKIFAEPSKSVAATSLWLLVAVLAVLDHPRRKLWLACLVAPLGAWTRHALSVKLNDHCKLELFPLGTLLANLLSSLATPGLLLVKITDPAAIVLVATVDAFQGGFVDSMATISTVMAEAHSLHKNSGKDKAWRAYLYVLFTMVTCFCVVVALVAAITSIPTKSFPAVPNIQEFSSPNATTSSLFLA
The following text describes a protein:
Function:
Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis.
Subcellular Localization:
Nucleus.
Sequence:
MTGLLKRKFDQLDEDNSSVSSSSSSSGCQSRSCSPSSSVSRAWDSEEEGPWDQMPLPDRDFCGPRSFTPLSILKRARRERPGRVAFDGITVFYFPRCQGFTSVPSRGGCTLGMALRHSACRRFSLAEFAQEQARARHEKLRQRLKEEKLEMLQWKLSAAGVPQAEAGLPPVVDAIDDASVEEDLAVAVAGGRLEEVSFLQPYPARRRRALLRASGVRRIDREEKRELQALRQSREDCGCHCDRICDPETCSCSLAGIKCQMDHTAFPCGCCREGCENPMGRVEFNQARVQTHFIHTLTRLQLEQEAESFRELEAPAQGSPPSPGEEALVPTFPLAKPPMNNELGDNSCSSDMTDSSTASSSASGTSEAPDCPTHPGLPGPGFQPGVDDDSLARILSFSDSDFGGEEEEEEEGSVGNLDNLSCFHPADIFGTSDPGGLASWTHSYSGCSFTSGVLDENANLDASCFLNGGLEGSREGSLPGTSVPPSMDAGRSSSVDLSLSSCDSFELLQALPDYSLGPHYTSQKVSDSLDNIEAPHFPLPGLSPPGDASSCFLESLMGFSEPAAEALDPFIDSQFEDTVPASLMEPVPV
The following text describes a protein:
Function:
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.
Sequence:
MACRCLSFLLMGTFLSVSQTVLAQLDALLVFPGQVAQLSCTLSPQHVTIRDYGVSWYQQRAGSAPRYLLYYRSEEDHHRPADIPDRFSAAKDEAHNACVLTISPVQPEDDADYYCSVGYGFSP
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MKPGDPRRILYTDMVATKDSSAPEQHGIAPSLILANRTAPISLDDKKREALQKERARRIEEQNKIFAARKLSLVLDIDHTLLHSVKFIEVDQVHDEILRKMEEKDREKPQRHLFRLSHIGMWTKLRPGIWNFLKRASKLYELHLCTMGSEAYATEIAKVLDPRGSLFEGRIISKANKGDPFDRAKRQQKCKDLDGVLGTESAVVIIDDSVHVWPNNKHNLINVERYLYFPYSRHQFGLNGPSLLEVGRDERVEDGTLSSILEVIEKLHQNFFSHCSLNNVDIRDLLASQQQKILRGCKVLFSGIFQADDMNLNLHPFWKTAEQFGAICTNQIDDQVTHVVARLPGTTKVNWALSNGKFVVHPGWLKASSFLYRRVNELDFARIDFAWKE
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Sequence:
MRVLFLRPDNEDNELNEKLMILRKNGIEVLNIPIFKIKCVSYSLPTYDYEALAFTSRNSVICFKDRTLIKNVHKIYAIGEETAELLMKMYNVNPITPERFTSIELAKRILEDKVNSILSIRSRKASEDMRNILNGKIKYDEIYVYDSEIIRDNINEISKILTECEVDAIAFTSSLMAKLIGPFIRGKCNIIIFSIGPMTTETLKRVNNKVKIIESKTHSIKGIIETILVEMKRNGRD
The following text describes a protein:
Function:
Probable transporter, its substrate specificity is unknown.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MVGEGPYLISDLDRRGQRRSFAERYDPSLKTMIPLRPYARLAPNPIDDAGLLSFATFSWLTPAMVRGYKHTLSVDTLPPLSPYDSSDTNAKRFRILWEEEVDRMGPEKASLGRVVWKFQRTRVLMDIVANILCIIMAAVGQTVLIHQILQHTESISRNVWVGTGLCIALFATEFTKVLFWALAWAINYRTAIRLKVAISTLVFENLVSFKTLTHISVGEVLNMLSNDSYSLFEAALFCPLPATIPILMVGCAVYAFFILGPTALIGISVYIIFIPIQMFLAKLNSAFRRSAISVTDKRVQTMNEFLTCIKLIKMYAWEKSFTNTIRDLRKRERKLLEKAGFVQSGNSALAPIASTIATVLTFTCHVLLRRKLTAPVAFSVIAMFNVMKFTIAILPFSVKAVAEAKVSLRRMKKILIDKSPPSYVTQPEDPDTVLLLANATLTWEQETSRKSDLKKVQSQKKHFLKKQRPEAYSLSPPTQGVTGPEEQSGSPKLVLHNISFAVRKGKVLGICGNVGSGKSSLIAALLGQMQLRQGTVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCALQEDLSSLPYGDLTEIGERGLNLSGGQKQRISLARAIYSNHEIYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTIVLVTHQLQLLESCDEVILLEDGEICEKGTHKELMEERGHYAKLIHNLRGLQFKDPEHICNAAMVEALKESPAERDEDAVLAPRDEKDEGNEPETDSEFVDVKVPPHQLVQTEGSQKGAATWKTCHTYIQASGGYLLSLFTVSLFLLMIGSSAFGNWWLGLWLDKGSQVTCGTRANKSTCEIGAVLADTGQHVYQWVYAGSMVSVLLFGIIKGFIFTKTTLTASSWLHDQVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILTILAAVFPAVLLVLAGLAVGFFILLCIFHRGLQELKKVENVSRSPWFSHITSSMQGLGIIHAYDRKQECINKFMVLNDENSSHLLYFNCALRWFALRMDVLMNIVTFIVALLVTLSFSSISASSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYILTCVPECTHPLKVETCPPDWPSRGEIRFRDYQMRYRENTPLVLHGLNLNIQSGQRVGIVGRTGSGKSSLGMALFRLVEPAGGTIFIDEVDICTIGLEDLRTKLTVIPQDPILFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTILKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDLVLVMENGKVVEFDKPEVLAEKPDSAFAMLLAAENKVRL
The following text describes a protein:
Function:
Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Sequence:
MGTPRTATIMRRNPQEDFELIQRIGSGTYGDVYKARNMQTDELAAIKVIKLEPGDDFAIIQQEIIMMKECKHINIVAYFGSYLRRDKLWICMEFCGGGSMQDIYHITGPLKETQIAYVCRETLQGLAYLHSRGKMHRDIKGANILLTDEGNVKLADFGVSAQITATMAKRKSFIGTPYWMAPEVAAVERKGGYNQQCDVWAVGITAIEFAELQPPMFDLHPMRVLFLMSKSGFVPPKLKDKNKWTPNFHNFVKLALTKNPKKRPTAEKMIQHPFFQQPLSHRLGKDLLEMASNPSSYQNHDDEDEEDRGEPTLEVPQRISSRKKEDRKERTKSEIDMENVNFEPPLRRETEPQQDEVRAGEVPNRVRRNDDEFAGAWRPVLEIDGSKSLIKSVEEELHRRGHTTTLEYSDAAGTDQSSSLPANGTGRPPGAPKAGQKSASDSEIISTQERRDGGTPPAHTTPPALPPKERANGVVPTANGEDMEEEQDVSEQENSEPPPDDEPPPPEVPPKVGDMNRPRPPMRSTWSRICHQETLAILQEPQCNGLPPTPKVHMGACFSKVFNGCPLKVNCAVSWVHPQTRDQHIIVGCNEGIYTLNLTQLHEATMDHLFPRRCTWMYVINNILLSVSEGKTPHVYSHNLVGLHDRTHTLGFNIPTHKLPDRIVPRKYAISTKLPDTKGCLRCCVVRNPYNGHKYLCTAVPNGVVLYQWYEPMQKFMLVKLPPYVPQHCEFSIPQPLRVFEMLVTPIAEYPLVCIGVSKGTNQNLLHFDTVNLNLSSSWFTEQGSALFDGENQLDVVNVTQLEKDTVLVAFDREVKIVNLSGKLKSSKKLAAELHFDFYTESIVCLQDSVLAFHKHGMQGRSFKANEVTQEICDKSRIFRLIGSDRMIVLESRPSDDPTAPSNLYILAGHEATY