lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site (By similarity). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (By similarity). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (By similarity). Together with PSPC1, required for the formation of nuclear paraspeckles (By similarity). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (By similarity). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (By similarity). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (By similarity). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (By similarity). NONO is involved in transcriptional regulation (By similarity). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity).
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Nucleus speckle. Chromosome. Note=Detected in punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles.
Sequence:
MQSNKAFNLEKQNHTPRKHHQHHHQQHHQQQQQQQQQQPPPPIPANGQQASSQNEGLTIDLKNFRKPGEKTFTQRSRLFVGNLPPDITEEEMRKLFEKYGKAGEVFIHKDKGFGFIRLETRTLAEIAKVELDNMPLRGKQLRVRFACHSASLTVRNLPQYVSNELLEEAFSVFGQVERAVVIVDDRGRPSGKGIVEFSGKPAARKALDRCSEGSFLLTTFPRPVTVEPMDQLDDEEGLPEKLVIKNQQFHKEREQPPRFAQPGSFEYEYAMRWKALIEMEKQQQDQVDRNIKEAREKLEMEMEAARHEHQVMLMRQDLMRRQEELRRMEELHNQEVQKRKQLELRQEEERRRREEEMRRQQEEMMRRQQEGFKGTFPDAREQEIRMGQMAMGGAMGINNRGAMPPAPVPPGTPAPPGPATMMPDGTLGLTPPTTERFGQAATMEGIGAIGGTPPAFNRPAPGAEFAPNKRRRY
The following text describes a protein:
Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
Subcellular Localization:
Nucleus.
Sequence:
MEEVIAGLQGFTFAFELDVESQKGTGLLPFQGMDSEWRCLCPLLRSWRCCASLPHSFWVFTARDRKADFRAARAPWVPPKPSTSCLRESSSAVCNFFAKGLCVKGMLCPLRHEQGEKLVVCKHWLRGLCRKSDCCDFLHQYDVSKMPVCYFHSKFGNCSNKECLFLHLKPVLKLQDCPWYNQGFCKEGPLCKYRHVHQVLCPNYFTGFCPEGPQCQFGHPKMSPPFHPSNVKLQPVNQPWDSTTSTGNTLVSPFQAKPMVHGQRRWSLPQACSSRAHPAP
The following text describes a protein:
Function:
Plays an essential role in chain termination during de novo fatty acid synthesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MPSISAVLSNFPLTIPPSKLFRGRSTDNNATLLYNFGPNLPSQVTRLQVKLDNVQDPLKLNNFTKTEPEKRRYTLDEYVVGQKFLVRLYELDIHQKASLEALLNYTQETGVNLFQSSGLVVEGFGVSKEMTSRNLIWVIGRMHVQVESYPSWGDIVQVETWCSGLTKHCLTCSSRLIDASTGNNIMRVDSEFVMINEKTRRLSKIPEEIKAKGDPYVKDYIDPPLTEDKLRKLHKLDQDKADYILGGIKPLWFDLDPNQHVNNVKYICWILEGTPEAVRENYELRSITLEYRRECGRDSVLQSLSAASAQVPDEYHHLLRLENGKEVARARTSWTKSSKLLRN
The following text describes a protein:
Function:
[Isoform d]: Probable transcriptional corepressor which modulates activity of the nuclear hormone receptor daf-12 to regulate the dauer diapause.
Subcellular Localization:
Nucleus.
Sequence:
MVQVPSTNTVKESRHVAISGLPSTLPDDRLQLHFTKFGEIQRLVRQHGNPEIVLVSYMDARGALRARSTKPQFEDSIEYKISAYIPEPTQNSSMASMSSTPSSGQSSSPRNAELSPQRYGDTRGAEVKSPSFRNQMEARRGGPHLSVQSQQRHSREYWPIPEFPSESTACVVYEIQSGSTPERDLFELVKKHSKRSGVPIDIQLESTTEPGWKKARVHYYRLDTDGLKADKSLILGRPPKFRVYYPTSGEQKHPQCHPSTSYAIPKLKGDHLLKASCSVHVPHLDRHSPDHYRRRFESYGQVIDVDMVKSNDNKAFAVVQFTNIDDAQKALQDTNIPKPMSYQSRPSHRIIIFYLPIECTNEEIMLIIRSLSDRIVDICVDWWDRSAVITLDDMEPANLLLKRMKLVGRNNFGEHKVAVDFCSDRFNLYFINRKKENIEVAARSSSPTSKSENDQGSSSPSSSRDRQNLHDPLQTRSSVEHHTNQEDQENNASGSDSSSDSDSEEGSSSSNEDSDEQNDVDEEDDEDVVSEEKRHEPEEGKSSSPGNGHRDESNGDKDHEDSSERFSQPSTSSHHETSHSPEKDSEAYQSRSFSPLNYQSQSPGYEFLESKEIKQEFSPTTSSASSSDLELDMEMPDNPLTRMLERMHWRPFIDVSSFVNRIDEIVELNQKARASYEKFTGRPFPKCNNDEVLSIQKIVFHEPRDYYYYENPCSELEVRIRDWRKLSDTADLDDFRATDSKELGRDQPAGGRTSGRPSLDESRTNRLSFDSTHHPAELAQRSHSLCIGPMTPSTPFPTSQPLLVNTTHLPGTSQPSTSGGITTPRSSQPPPLMSPVSRHNSMSSTGRPASIQTLRHQSVMFPPDVSIPPPPIPPTHDEMMAPRGTPPSRRSSETMVPLRSPPFGTPIQNLLTMPIVPPPHLIAATSTGTHSVSSSAHSTPRHSISGTPVHCEPSNSKTSQPPTPKSRPEKVQIRHDTISKSGPSNAINALQARSQSMTSGDPKKSAPSTPVVRDAGSDLVAQIMSNQPNLGLRKLPRIEKKSSALQNIQNHQPPHSNANSTPSTPSTSTHQAMFKDKEKERKKKEKEKEEREREARREMKRKETKEERNKRKEMERAKRLEDERQERKREKKKERDERKKEKEKVRKKAEKEKLKKKKHRKGDSSDESDSDSNDELDLDVRKSTKEMTQEEKDHQLALLLSKGGIIENLKSRRRSDKRAHDSFEKMQQKSQQRRVLIESSDDEGGKDGDKGNSSNGEESDSEKADLPPPPAPPSLSESADQRLKVLKEREKGELTTSSDDEDHNDAGEIHQQRLTEDRENRKRQKSLTAYSSDEQGERKNVPKRMRRDDSEDAAAKHPGWSAKDDQKQRKRKLEHRRSSEDESKKNAKRDFRDIPHEDVSDEEETEDGSRSRRQSTSSTISNVTAKERKEKSGKTPLRIVPEPTGTPLLSPKILSPKHLSPKTSTSSTKRSSISDHENLISPRQRNRTTSSTSTATTSSKHEALSIPEKPLSPPVTAKSSVSSIDDPSIRDEFSMNSAADSPMSTTGRPMVLTKAAMKAFNSTPPKKKNSSSGQHDSSSGSSSDSSSSDGSTSSDDSSDDEVPKQTEPVTSIPVVASDNGSPENVVVETPSIVSQTPREPEPFTISEQSSESEPEAVPECPEASVEPQMETSQNVEPVSEEHEDSHEHGDSEVAVESQQQPLEHQEEKEELENKILDVAAEHHEEQVQGDEDSVESSIPAPSDEPDPVTQAQEKSAHTLISDQETDQAVQSIFDEEEADEFPQYPDFGISTNEKEVSGKDPHNIKPTEPLNNGHTDLLFSPSSSAHASEKQSTKSEDDMEEDSELVVMEKEVPMEQVIAQEVHVPSEPSPMEEEVKLETSPVPKEEPIKMEESPEQTPTPDLISNNESQDTPGAVNNHLHENHDAVQTPIQLQPASQHQVAQPSPRPAVAPDSQQNGPVLVSQQSQPSPMSSQQSDMAQNLILSSKDINDLAAKLHKNPEALAQATRGDCSGIFQHLLLHAQGNGQNMTPEMLQLKAAFFAQQQENEANQMMQAKMKQQTINKDRIKEQERVKRMYEENERKVEEDRREKQRKEEERQRLAAATAAATMATQKAAEALKQKQEVPRHGFQHVLSMMTPEARSLYEQFPGLSSYINRDSIGATNGVLHLPTQSIQRPSSTASTSSNPPKAPLQPSASVNQNTIDPAEIEEIRVQRWFYKHFPMVWTGRLALKSTEAMINLHLINGSETFLNDVLGRQVTEENPRRDSVKILQRLRLDNGQVEHIYRILTNPEYACCLALSSVNNIENLKENDTNLKSHFIDYLINKKIAGISSLGEVETKFKSARVHVFAPGEIVNRYLSELATSLHDYLQNTDTRYLLIVFTNDKADPNMTGPPSVASLAVPPVSST
The following text describes a protein:
Function:
Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MEQLFQNYRDDERRIGEEYLSSLQDLNCNSKPLINMLTMLAEENINYAHIIVKVVEYYISQVAPEFKLPILYLIDSIVKNVKSSYVQLFGQCIVNIFLHAFESVQHSQSQVLEKVRERMYALRQTWNEVFPPSKMYALDVKVKRLDNNWPITAKQPTNKIHVNPAIHVNPDFLKPGLVPGMPGNPTITSDMEEILQAKTRELLELKKRKLELELEQTKKHLEEQERQLTQTTDAMVGAPIIMPAPTPAAICPPITDPGIAVHNQRAPGVMGNVGPVMHNMPVAPQLFANKPKVHPVNPALLNSVRQRDPRLARQMHAASSHPAAPARNDPRLEAKSSSSQKSSRSRSKSPVRNSSSRSGKSGSSSHSSSSSRKRSESKSSTTSSSSSSSDVRHKGVTASSSNQPTVKRSGKITSKDSDRYVRNGSPLGSAKRKSSSPSSSPSKSKRSTSHKSSSSRGKTSSLRSRSRSPVFMDVDLRTGVRSKSPESRAVAPSSLPLAGASLPASAKAPKDLEKLSMLNSNPTTSGTPAASLVRQSSPSPSSSSISSQGNVSDALQLSINKLLQVQGGAGEKRPADALPPHIDGEEQPPQQKRSKSAKLDALFGSEDVDLRREILVVKPGVIVVEDDSMDECDVDKPTKKSGSPPKKATLEELRAKLANSARIQNKQGKSDKSRDQAVSQRLKQLAELKVNDDSQEAHDEKVRTILSQAQEMYENNGMNQEQYKDLVQKVVAINENSKIKESRRRDNDLERNAARDAVLRKRIPKLKGNENHSAGSPHTDGSPRYDDQPAAAPEKPSNKRDKTKREMKRRKPTKWGEQVDAGAAQRTAWQLANVNNNNNNNNNKRGGIQLPVQPQAGFRGMPWQQPPAMVLGQSAVPPPPQPPSMISMPPVPPVTMTKAINSLDNPMADVVRSITIDGGSKEIRFYNQVAIIFMDGDQPHEIGFQPGQRVIFIDHNEPLPLCFNDDYKPFHLDGQLHRIRFGFPSRELYIDEHWYEIYFGGPAVSVPIGNKLHIIKAEGPPPNVDIGRVRRDLVVGKINMIADAHTIVPLFLDARQQTFQLGAEQHSLQFVDSFQYALLDGQLQKMEYGGLPKGMMLNGGRSCFIRFGTLPKGVIAGKTHVADMVYIKTDAPAEPPKPPPIIVKPPPVVEQPKPAPVAVAPISLPAAAAALESLNINDLFQKLVSSGIIGGATAAPTLPAADSSAAKEPTASATEPSTASATVAPATLPAGPPAEPIKRIDLRKPESIKTRQAAVVAVLYLGMQCSSCGVRFPPEQTIKYSQHLDWHFRQNRRERDSTRKATSRKWYYDLNDWRQYEEIEDVEEREKNFLEAQGQPGGVEALDELSQQRSLDSPVPTCAAGRDDVDHCCDMCHEKFEQFYNEELEEWHLRSAIRVEDKIYHPLCYEDYKASLNPPTEVKSDQDVDMNNTDDNAMDTLIKVEDDEDEGTPNSSQPIFEDDDDDVIVLPNEEPSVTEIVDDDDEDEYVPGNVTRADMGNESQDKTESNSETKEPKKDQVELGEQQQNESANESDVEIQEPNIPFTDLDTYVEKEMDEATRAALLNVKIKEEPKDEYEEDEDDGFEDVGTVVSLLPLPEDEISIHSSETQTHTIGSSASPATIERPASVTSLSLPANEADELEQGDANTDTDAELNGEKQEATHNLSAVGPALPLASIVNKIKINITKNTSSNSHNSASNTTTTDSQVSAISVIGGSGAAGGASGAGDPVQQVNAIQTISTIPVLCGGNTFVPKIATSTPSNVISSISVIGSTYGASSSSNGSRSTTSTASSAPAASLLAETGSLKSPTPPLATVDPDPEPVVEQKPALRNATLKRTKKVQNGIETSGLCSIM
The following text describes a protein:
Function:
Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore. Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure.
Subcellular Localization:
Cytoplasm. Note=Localizes to cell poles and nucleoid, in a DivIVA-dependent manner.
Sequence:
MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVKVLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQDESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIPETAAASEKTKTRKKPLLSLFKFQT
The following text describes a protein:
Function:
Cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system. Acts by forming homophilic or heterophilic trans-dimers.
Subcellular Localization:
Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.
Sequence:
MEAVQKDRWYLLVLLFLTFIKAALLQREVEAVRLEEGMVLSCLCPWKGNLSMVSWTKKHENNPVAVFHPEFGKSFSHRYRDRVEFLRTAPLDGSISIKNVTHQDIGNYQCSVQTFPQGPWTTDIQVEDLDEPPSFNITDLALPEEAVTVAQLVEEENNNLTIRCIHPHNVTIINQVILERKLHEQLWTIIGVCKQVDGGLLSEDYSDRGRVDCADSLEVSLHLTGIAQEDGGFYRCTFNTDVGVRTYTIQLSVSPQGGFSLKLYMMYVYIGAGASAVLLLIIILILAMKRRKQSKRVEYRVKLHPSQRQPNIYENVCVHHRTKKKPRQLRNNPVYANLQAVRSLQSRRQNRPL
The following text describes a protein:
Function:
Inhibits host NF-kappa-B activation stimulated by IL-1 and multiple PRR viral detection pathways. Targets host NF-kappa-B component RELA/p65 for ubiquitin-dependent proteasomal degradation.
Subcellular Localization:
Host cytoplasm.
Sequence:
MMNFSDPCLLGPSACNEDFFEELAREILPTPEAKALAARLLRRLGWHPSEGQCSWCPEAYEYLYDLQFRYTGPVPLVRKHPGSALIVRWMLDGLGHFLFCRPRVQGNPLTYHLSCMGSAIRTLELFREQAHSHLWEQGNLVDCYWSCSSDYGYEGKWGQQAVVRGALSGPWPRPDPPSLQLQCLCAIWRTCLLRGQSQAQKYTNWICARHLQLRPDTSTRDSDLLLQRC
The following text describes a protein:
Function:
RNA-binding protein, which may be required during spermatogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MNNSGADEIGKLFVGGLDWSTTQETLRSYFSQYGEVVDCVIMKDKTTNQSRGFGFVKFKDPNCVGTVLASRPHTLDGRNIDPKPCTPRGMQPERTRPKEGWKGPRSDNSKSNKIFVGGIPHNCGETELREYFKKFGVVTEVVMIYDAEKQRPRDFSSPGAKLYHTGFGFITFEDEQSVDQAVNMHFHDIMGKKVEVKRAEPRDSKSQAPGQPGASQWGSRVVPNAANGWAGQPPPTWQQGYGPQGMWVPAGQAIGGYGPPPAGRGAPPPPPPFTSYIVSTPPGGFPPPQGFPQGYGAPPQFSFGYGPPPPPPDQFAPPGVPPPPATPGAAPLAFPPPPSQAAPDMSKPPTAQPDFPYSQYGYGQDLAGFGQGFSDPSQQPPSYGGPSVPGSGGPPAGGSGFGRGQNHNVQGFHPYRR
The following text describes a protein:
Function:
Adapter protein for ddb1/cullin 4 ubiquitin ligases involved in transcription-coupled nucleotide excision repair.
Subcellular Localization:
Cytoplasm.
Domain:
The DDB-box is specifically required for ddb1-binding.
Sequence:
MNSFLLAREWGQEPNSSFRRQLLQHRLQRLALNPDVKIKRRHGAGILGSVNALSIDNTIHQLMVSGGANSSINVWDLQNIDQKEDEDLILDTLNAVPARTSHKFGITDLHWFPFDNGIFTSSSFDHTLKVWDVSTLQEAYTFTMEDMIYSHAWSPIASHCLIATAYRSSSIRLCDMQSGSYTHSLSGHTGNVLAVDWCPKNEFVLASGSADGTCRLWDIRKVSSSFACMDLHNKYLPSNQTNISHYGTVNGLAWTSDARYLASCGTDDRIRVWNMESGRNTLREFGPIIHNQTTSFAVHPCMIQPSMDSDVFVLFPNDDGSLALLNLLEGSFVRRLSTHSLKRINCAAYRPDFEQCFTGDMNGNIYMWSPKALKSPTKISDLETRRNIIQEVYDSLINIPVTYQ
The following text describes a protein:
Function:
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
Subcellular Localization:
Cytoplasm.
Sequence:
MTFEMLYSKIHRATITDANLNYIGSITIDEDLAKLAKLREGMKVEIVDVNNGERFSTYVILGKKRGEICVNGAAARKVAIGDVVIILAYASMNEDEINAHKPSIVLVDEKNEILEKG
The following text describes a protein:
Function:
Dihydromonacolin L monooxygenase; part of the gene cluster that mediates the biosynthesis of lovastatin (also known as mevinolin, mevacor or monacolin K), a hypolipidemic inhibitor of (3S)-hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR). The first step in the biosynthesis of lovastatin is the production of dihydromonacolin L acid by the lovastatin nonaketide synthase lovB and the trans-acting enoyl reductase lovC via condensation of one acetyl-CoA unit and 8 malonyl-CoA units. Dihydromonacolin L acid is released from lovB by the thioesterase lovG. Next, dihydromonacolin L acid is oxidized by the dihydromonacolin L monooxygenase lovA twice to form monacolin J acid. The 2-methylbutyrate moiety of lovastatin is synthesized by the lovastatin diketide synthase lovF via condensation of one acetyl-CoA unit and one malonyl-CoA unit. Finally, the covalent attachment of this moiety to monacolin J acid is catalyzed by the transesterase lovD to yield lovastatin. LovD has broad substrate specificity and can also convert monacolin J to simvastatin using alpha-dimethylbutanoyl-S-methyl-3-mercaptopropionate (DMB-S-MMP) as the thioester acyl donor, and can also catalyze the reverse reaction and function as hydrolase in vitro. LovD has much higher activity with LovF-bound 2-methylbutanoate than with free diketide substrates.
Subcellular Localization:
Membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MTVDALTQPHHLLSLAWNDTQQHGSWFAPLVTTSAGLLCLLLYLCSSGRRSDLPVFNPKTWWELTTMRAKRDFDANAPSWIESWFSQNDKPIRFIVDSGYCTILPSSMADEFRKMKELCMYKFLGTDFHSHLPGFDGFKEVTRDAHLITKVVMNQFQTQAPKYVKPLANEASGIITDIFGDSNEWHTVPVYNQCLDLVTRTVTFIMVGSKLAHNEEWLDIAKHHAVTMAIQARQLRLWPVILRPLVHWLEPQGAKLRAQVRRARQLLDPIIQERRAERDACRAKGIEPPRYVDSIQWFEDTAKGKWYDAAGAQLAMDFAGIYGTSDLLIGGLVDIVRHPHLLEPLRDEIRTVIGQGGWTPASLYKLKLLDSCLKESQRVKPVECATMRSYALQDVTFSNGTFIPKGELVAVAADRMSNPEVWPEPAKYDPYRYMRLREDPAKAFSAQLENTNGDHIGFGWHPRACPGRFFASKEIKMMLAYLLIRYDWKVVPDEPLQYYRHSFSVRIHPTTKLMMRRRDEDIRLPGSL
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.
Sequence:
MRIRKSADVIIAGAGIMGLHTAFQLKRRAPELGVRVLERARAVGQGSTGFSSAVLRCRYTLPSMVDVAAEGLKIHNNWSDYLELPRPLASFTQHPILWVMPETTYQQDVQRLARHGLNTTVYYSADEVGERFPALDFSQDERTGVVQYFVEEDGGYFDPTAALTDLLTACRNIGVEVMFNTEIERVHVMDDSTIELVKLSTGDSVPCGALVNCTGPWHDKLNDIVGWDNDWDIQPARIQVVHKPLVKQDPAAEDIPAVCDAVNGVYFRPHLQGDHIIISTVRPQDEEERVEEPDDFNTAADPEVRQRYLSSLHARIPGLTPRGTVAGYSALYTVNYADSHPVVGRVHPFTNYLVANGFTGHGFKLSPVVGAALAQAITGSTTRHFDTRTDWAFLSPNRNPITAHRQGVLS
The following text describes a protein:
Function:
Lysosome fission factor. Recruited to lysosomes by rab-7 at scission sites and homooligomerizes to mediate the constriction and scission of lysosomal tubules. May sever membranes by inserting amphipathic helices into one bilayer leaflet. Lysosome fission is required to maintain their steady-state number, shape, size, composition and function, and to accomplish regeneration.
Subcellular Localization:
Lysosome membrane. Note=Recruited to the lysosome membrane by rab-7.
Sequence:
MAATSQVSSLLDLIMSLLDTATTYQHQESVKNEVAESLKTIGSHQPNVLLTACHQYLLQNPKLGAFKRAFVLQTISICVDNCEVVSKLDEQIIMLIINLATQEMNMTKDTDVEWAESSMEVLVTLAKNTRFVSHVIDAILQKFPPGQTTSPHRYIVLTMATIAVHNPFGLVPFLTDILSRTVPLLQHVKTDPLRCAWARAICSFCEAVRECETERPKEASEEYIGDHSRPNSASGHCQEVSNRATYSDQTEAVYDVIFSWIYSKDPKTRGEAAECVGELCLMIKQTRLVEDVKKIVTNMIPLYRKSYNESHMITQGICRFLEAACVDETCPLEPYLEDILNALFPNACLDPDDTTVTLSTQAIKNHSEAFRCFDVAATRFADRIVYYLLHKMQNVADSQKLGAINVLRHLLNATGQHMEDKRSLLTMGLKKLLAAENTTSIRVKRAIVQLCVALADHSYVDAEGGDYVIAFLVRNLVGPTEQESAAKKVEVDVAGLNQLRTQCAQALYTIANTCVCATKLLWPYLLEFICCERYTPVVGDLCKCLRTLVSREVEAGRKMDYVTGFDNPKVAGRHAVFARLFTSFCNAPLNGLLTRRAREAGGLIQAVAPWFHPSMEGPAARWSEKLEPLLDELSTTVSSGDSAPAELRGRKIARWHEACLDWLSACVAVVPEGDWRQDLAAAMGKQLDMYKELSDEKSFLLRCLGVTLARITAKQFVIDHMMLMFKSASHSVLTERQGCARGVGSIATSHMDLILIELENVSKWEHARKSSGIFGFIKDTMPIRQYPDIEMIHLRATLMLCYGHVVMACSLDTITQRLQNTIIVFLRNYFANSKQETVVREAMLETMRLIATAVHPSRIGGEWKFEARNELLAYAKDYLNGETPEWLTSSLRLLACKTTAALVQLEPPLSPADIEDIGTVLTRQILPMQREKSGLKTLAFDIFDYASSSVFSTFSGSSSSHTNIYMTPPLTANSVAEGPNGTPIHQRHRGIGGKMEDDESATIMDATMHQYGLALEQIVRMAPTTQTIMILLKILLPYYGKQADHERIRAVDMTVLVLRVYYECAEDISLGHASDFEPLSSLLGRLAPRLIDLLAHVRLQALSAIHWTLRLAYMHKGHGRDADQSLFSYSGFVEKYLTSGDVKLEGQKEKLAIEAIAQIIEYRLPQSQMQIYLSAIFEMLTDRQSHVSSAAAQLLTYAVMARGATLNAEAEILVTKMVEKLADIHHCVQTNTDVLAALVAFAVHQQQAVCDVLFKQPLPYSINITDAWECLSRDKLLFAVILDHLTELLGASLDQPFELMDSGGGVSAKVVNVEPCTYVAVLAEVVKNGEPESALMERLPLILTLLIHFICSVSDTQFPVMQKEGSKNPLIITPDLRRAAEKPAGMAVAAIKNLLNRTRSNMVIEDMNQARAWTDCLDKDSFIQAITVFIRSLVEQRPAWVSPLAKTMEEYANSESEPRRLAAVIIAASLIRRSTSENGEFNEQLLVKCIRRLEDSLTDPSLRIRKLCVKGLGELSECSSTDVISRFVHMAVEAAMSGLDDHGDRKDTVAIESIMALNKLVQLTNNDQLKSILPLVLLKIRPCFEKDSHTLRAASFSLFGELGSRVGENSEEFRGHLHTNIVSLLLHLNDDFEEVRQNCANSIYRLHGLLTSPNASICIERELKDGKQPASYNLFIKDFASILANSFPDRINQYALATSNYFKSSSARIRCNAAHLTGCLLDGLTAPLRATISRELVFTGLVALLKDSEDVNVRISATRAIANLHDFH
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MDDELFTRPWRSKDDARVGLGLVEKIVTSECSNGLPLAQYLAQLRSVERSPCTTVWRAGSFAYRCRDCQVTDSSAICVECFKAGPHVKHDYIMYRSAAGGCCDCGDPVSLKEEGFCSLHAHREQAAEVLPERTLAVFQKLVSLLLARLVGMVSLLELGITTVSEGTELVLKWLQQICSVPALREVVCREMAGGSAEGSLEPQPGPLAPLSVLLKNFVIVPSVAEEETTLFLLMLYNHQFKKSFSRVLLRNYADWVLNNVHNEDAFKLLDSCLDRVMVQLINVESITLDLIKQERLLDCFLHVLRDLLKKAMDPDTNMINCNHDVIANRLYTRPLSDLRLIVSHHEVGLYILVQRSDLLHGYLALLETLQNMHPIHHLAFRDLDEDIGWMHAVAMETYMTSLMTQLLTGCDPSQESPGFAGASRRLLFPALHSAATVMHAMLARFYISDYLSSAPNSRLGFSGVCMSLHLPLHRAFGMVLAKLLHFATSAGVADQFEARACLQTLASQVESQRKLAEPPGVAGKHWAASQAGQLMEYPLRILFWMAEIRGRQWRNQGEDLARLERVYQSAYWNEQTMDMDVLVVQFSIATGGEDSDELLLQILERYKVADLLTKDGRPCSDPSSSDPQIRSATLARMLEVLRLILQLVRERRYIAMSEIELVRYEVIQWLCCKDMTYSTLSNFLPQALSSHARLEEVLRSVATYVVPKLQERGFYRLKPECWREFDVLFAHYTKGDLEEALSRAVDIGKLGSYWRLPPLEAAQPPFDTLCNILHSQVFHRFLYVALDQSLQLLESETNSTVGKSLGVVVSQLITTAALDDRQGPGNRRYRSCTPHEPSTFWPFLNFALNDIAVNIRRGAGGTSDGWSMLDLFRRIRQATNSNRLLDSVQYVFETTKALTVDIGKTEAPLATAEASTSSPDAESQRQLKKQRQAAILADFAARQKAFLSESRTASEAGPSGTEATFGAAQQDNAVRVGETVHQEPGPSGRVHERVHRECAFCLGDQEMNPSPMGWIAFIQMSNIPAKASQQLQRVETLEQAEEQATCERDGEGAERILCSVLAQEGTVDGTRGEDLYATGEHVGCCGHQMHMECFQRYVKALGDSRDSGRVYEGYGIINLARVEYLCPICRRLSNFLLPDVETEPPVVRTVESDAPSEQLPASNFPGLLAGLSQSADPALHQFWNAKFRQYENWCQLFVGQCRILRMDSQPDVPAPDLASPPFVWRELWSILAANVVHCEVETRGSSGAAPRGTSSDQVEGELLELWGGASAHWRALRALAKLAVLSTTFDEEPLMQREMGILDWQAALGAGPVCGGGLNPKGRNGDDATGPMGVPDNGQSDSLGERVAAASGVSSTANAAPEFGAQFRGRLGSEPSAKEASGPLDRKGKDAALSDGEAAVRAGANGPQKVDKQPLEERDVTGDPSPAAMDATSGAPDEGTEEEDASDESPLEQDPFWILVFLFQTHVGFPSHTGALAMVNVAYHAAAAQAFLAAAALRRSDADEPAPVDLALMAVVQAALVPFLRRAAILVHVVSGRLPPVSGPGALDGDLMSYQYWERYLGLPPVPSVLQAMGIAPPSKQVMPPTAPVVPRHLLLSGRAQLKLVDLPDVFQELLLAEMNRKCGRCGTVPREPALCLLCGTLVCCKSQCCHVEGRGECSRHAAECGMGIGIFLLLRSTQMLILRGDRACMAPSIYLDVHGEEDAFLKRGRPLRLSRLRYDEIERMWLTAGLDQNSQLLHSSHLGSESL
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.
Subcellular Localization:
Endomembrane system. Golgi apparatus.
Sequence:
MDKKATALLKLAYLEMFGYDMSWASFNVLEVMSSSKFLQKRVGYLGALQSFRPETEVLMLATNLLKKDMVCSNLQIISLPLNTLPNIITPSLAMSLLPDVLSRISHSSPSIRKKAVVCLYRLALVYPEALRLAWPRLKDRLMDETEDSSVTTAVLNVVCELGWRRPHDFLPLAPRFFELLVEGGNNWMSIKIIKLFATLTPLEPRLVRKLIRPLINIVQTTTAMSLLYECINGIIQGGILEGEGALEDSHEIADLCVSKLRGMVVTDFDPNLKYVALLAFSRIVVSHPHLISMHQDVIMNCLEDADISIRLQALELAARMVTGDTLQPVVERLIGQLEEPQHTFPKGDASDAGDVAVLANHVGRRELGKHPAYFPISDEYRVEILHRVLDICSHDNYSRLTDFEWYVSVLIRLVKHLPTRVEEHTVSQGFESSSRDDAASRIGLEMRNIAVRVKNVRMEATRAAEFLLLVDNRQSVFANVSLAYNGVLGPLAWVVGEYAEYLSSPGPMLQSLIDVSTTSLSGRALVLFVQAVPKVLARIVHDYMGTWDVRQRSEVSLFLARIVEFYEGLATHPDLEVQERAIEFLEIMRLAADVMQTSTQQAQVPYLLSSIIPSLFYGLELNPVAPNAQGKVPLPDQLCLNVPFNDNVRKLFESYQDGFYAQPYDFYRVGVTQLPHKQQGGFNTIEIQPNFSYQDPDILDEALAASLRQKLEWKQRNREDPFYIGADERNDATAPTERPFGSVHSEALDVDSIPIIDLKISGLGDESTPKARSYDSQGKLAGQPKKYEVIADEVLDLEETADFSSPDEPVKAKRALLQVDSSGLKDLTLGDDGLAHANGVPGKSEDDAEMATAMKEIEKIRLKMQRASERVELEGAPSDGMVVKKRRKPKKTSHNKTRKGYSLQGENSQSEHGKSSSTVHKRTRKRKGDAERLG
The following text describes a protein:
Function:
Plays a role in the regulation of phosphate uptake.
Subcellular Localization:
Cytoplasm.
Sequence:
MAIIRQRYQEQLDDLIKELRRLGANVYVSIENGIKSLSIDDRGFARQTVKNDKHINQLNYDINERVIMLITKQQPIASDLRMMISSLKIASDLERIGDNASSIANIRLRTKITDDYVLTRLKTMGKLAMLMLKDLDQAFKKKDTVLIREIIERDEDIDDLYSHIINATYLIDNDPFVAAQAHLAARHLERIGDHIINIAESVYFYLTGTHYEQ
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MTETPNTSSEEIQTSEPSPDNELQVLQQENANLKAELQEQNDRYLMALAEAENSRKRLQKERTEMMQYAVENALMDFLPPIESMEKALGFASQTSEEVKNWAIGFQMILQQFKQIFEEKGVVEYSSKGELFNPYLHEAVEIEETTTIPEGTILEEFTKGYKIGDRPIRVAKVKVAKLPAKGNSDSNEEKE
The following text describes a protein:
Function:
Involved in the export of mRNA from the nucleus to the cytoplasm.
Subcellular Localization:
Nucleus.
Sequence:
MMNRTSAPPRGPRNSSSSARGGGRVGGGGISKRRAGPIRADKDGDLDMDTTTAASGRKSGKGAIGGSLPSGPRGHGRGGARNTSRGGGRLDLTRNPQAILRGMGSQSQQANVLVTLWIKGLKGSKAALNDDQGLSSLVSFIERKATTLESRSKRCVRVKKSHKKGDIVVISVTPEDAATIMKLDGFAFAGSTIGVQDSEPSKMSEPKEESEEARSTREKIQAVLAARYDTNLKLLNLSALGQDEQLRQMGIFQDDTLVAKLFPVLMVICNKLFTTKQAKKDAIVSITLTDNYLTDLSNVTSLASTFPDLKNLDLSRNQFDSLESLKLWRWKFRHLENLVLSGNPIETLVPDYTTEIVRWYPELQQLSGVQVRSVAQVVADLEAIKTPFPIASPSFRDVGQVAENFVKHFFGAYDKDRNTLLSNFYDTRSAFSLMVNMSAVRDRDHSMPVPPWAAYNKSNRNFVKYTHLSTRISRQSTGIEEIQQMWSDLPKTLHPEIATRPDLYLVECHPIPGLPDLSGQSAAGVDGLLIDVHGEFEEDVANFEGKALRSFSRYFILGPGGPNGPAIRVISDMLCLRAWGPLPQIAEVFVPPKVPIVAPPFNTLPTGEELNKIRAEKLSAETGMNLQYSALCLEETGWDLDKAFAAFQANMANLPAEAFQKP
The following text describes a protein:
Function:
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Secreted.
Sequence:
MVLSVQALGLVVLAAILLQTIAVAVSFMYFSRVLNTMQENFSQSSVSCLINVKLPSEVVDSAAEDKNSDPCWQVTQQLHYLIEKKIADSFQKEISSAVSNKLTGVLPVLHPGIPGVPLPKVGAHVTGVASSLKPPIEESSRSTTGYFGERIRAWEGQRGLSFLQNMELRGGELLVPRAGLYYIYAQTYFRLASTGDPETEEGAELVQYIYKKMSSYMGPILLMKSSRSACWPQGQEPGLFSLHQAGTAFLQPADRLFITVSNASAVEMDGRASYFGAFLVS
The following text describes a protein:
Function:
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
Subcellular Localization:
Secreted.
Sequence:
MNAFLLSALCLLGAWAALAGGVTVQDGNFSFSLESVKKLKDLQEPQEPRVGKLRKFAPIPGEPVVPILCSNPKFPEELKPLCKEPNAQEILQRLEEIAEDPGTCEICAYAACTGC