lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSQSTTRASSAPRASASGLTRVYLLAYNAISFCLWATCVIRGATLVFSLAPNGHLPAIFHHVYSPLLTTTQTLAGLEILHSLVGIVRAPVMTTAMQVASRLLLVWGVMYLFHDRGNGHGGIVGGDFHEALPYGPGAKVGDYAFLGCLGAWGVTECIRYGFFALQVWGSGVPSWWTWLRYNTFYVLYPIGISSECIMVWKALKPAAEWNPLYWWFLVVVLIIYVPGSYILYTHMIAQRRKVMKKKGRAD
The following text describes a protein:
Function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Sequence:
MIDYKSLGLSEEDLKVIYKWMDLGRKIDERLWLLNRAGKIPFVVSGQGQEATQIGMAYALEEGDITAPYYRDLAFVTYMGISAYDTFLSAFGKKDDVNSGGKQMPSHFSSRAKNILSQSSPVATQIPHAVGAALALKMDGKKKIATATVGEGSSNQGDFHEGLNFAGVHKLPFVCVIINNKYAISVPDSLQYAAEKLSDRALGYGIHGEQVDGNDPLAMYKAMKEARDRAISGQGSTLIEAVTSRMTAHSSDDDDQYRTKEERETLKKADCNEKFKKELLSAGIIDDAWLAEIEAEHKDIINKATKAAEDAPYPSVEEAYAFVYEEGSLN
The following text describes a protein:
Function:
Catalyzes the transfer of galactose onto proteins or lipids.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MVRWAFPLKRCSAHPKKLGLLVAVFTLGYICIDRNIFFLDRVSSKLPRDILSVDSKYVGGSAKNADQKVDLYHNGADELHLSDLSKGVTEKEVENMKQTVQYLTLDDIKDGKVESNTKKFDGSSMCPEVEDNPNMKGPIPQAVLLIDNLKESEVASIHPELAPGGQWAPDDCKPRHKVAIIIPYRDRQSHLTRLLYFLIPILKRQKLDFRFIVTEQWGNDLFNKGRIMNAAFRLAERLGTDCVIFHDVDMFPQDDRNPYSCPPSPRHLGAFVSNLGYQLWYKEIVGGALAISMADYRTVNGYSNMYWAWGGEDDDMGKRILSLNYTIERPNPVTGRYSMLKHVKRKRTAPKLIYKLLEIAEQRVATDGLNETDKWNVVKMMQRPLYYHIFVDVGEVPQEWRGNGKDS
The following text describes a protein:
Function:
Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. May contribute to a sensory discrimination between mechanical and chemical stimuli. Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response. In AIB interneurons, promotes omega turns, a movement that frequently follows backwards locomotion or 'reversals' in response to environmental cues while possibly playing an inhibitory role in alternative neurons to inhibit omega turns.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Synapse. Cell membrane. Recycling endosome. Cell projection, dendrite. Perikaryon. Note=Partially co-localizes with lin-10 at synapses. Trafficking between the plasma membrane and recycling endosomes in the ventral nerve cord is regulated by lin-10. During hypoxia, accumulates in enlarged endosome-like compartments. Co-localizes with rab-6.2 at or near punctate structures in the neuron cell body and along the ventral cord dendrites.
Sequence:
MFSSFSFLNMFGVLFTVFNLTVVQPYPSHIIIKSFGNNEEVSRVALKAMEYTSDHINSRDDVPFKLAFDHRVVEEGAAVSWNMVNAVCDELKEGAMALLSSVDGKGREGIRGVSDALEMPLVSLTALSNDDHQQQQFGNLFEVSVRPPISELLADFIVHKGWGEVLVLIDPVHASLHLPSLWRHLRTRTNTSVKASMFDLPADEKQFEAYLMQFNMMRNNETNRILIDCASPKRLKKLLINIRSAQFNQANYHYVLANYDFLPYDQEMFQNGNINISGFNIINKDGREYWSLKKHLKTSSSLGGGDDVSVEAAVGHDAMLVTWHGFAKCLQANDSLFHGTFRHRRFFNRGFPGIYCDPLSDRSHPNRPFSSFEHGKTIGVAFRNMKIGHKEGTLTGNIEFDRFGNRKNFDVSIVDLVSNTKATFNSKEVLAWRQGVGFFSNRTVAQHSRKSQNDHKDNQVIVLTNLVAPFVMIKRECLEMANLTECQGNNKFEGFCIDLLKLLADKIEEFNYEIKLGTKAGSKQADGSWDGMIGELLSGRAHAVVASLTINQERERVVDFSKPFMTTGISIMIKKPDKQEFSVFSFMQPLSTEIWMYIIFAYIGVSVVIFLVSRFSPYEWRVEETSRGGFTISNDFSVYNCLWFTLAAFMQQGTDILPRSISGRIASSAWWFFTMIIVSSYTANLAAFLTLEKMQAPIESVEDLAKQSKIKYGIQGGGSTASFFKYSSVQIYQRMWRYMESQVPPVFVASYAEGIERVRSHKGRYAFLLEATANEYENTRKPCDTMKVGANLNSIGYGIATPFGSDWKDHINLAILALQERGELKKLENKWWYDRGQCDAGITVDGSSASLNLSKVAGIFYILMGGMVISMLAALGEFLYRSRIEARKSNSNSMVANFAKNLKSALSSQLRLSVEGGAVAQPGSQSHNAIRRQQVAAFLPANEKEAFNNVDRPANTLYNTAV
The following text describes a protein:
Function:
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein; Extracellular side. Note=Localized at the cell surface of melanoma cells.
Domain:
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence:
MILLAFSSGRRLDFVHRSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFNIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRRAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSVPPADPRRHDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGNGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITIWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRDKEGLSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Sequence:
MAAVQKGQEVPAVTVREGTPSCQFDLQDVTKEGTHIIVGVPGAFSPACSAGHVPGYINLFPKLKERGVKTVWVVAVNDAFVTNAWAESLDAPADDVRIISDQAGEFSLAFGTLFDASEFFGNKRSARYAAVIMDGKVVEVFEEPDKTGLDVSKAENVLKSLG
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MEPESSLHKVVVPLDLNYPRICSHCQTSKTSVWRNGPFGPKSLCNACGIRYHRKGIDALELEGKRSKDKKRKTSRNEVPLRRGLRKNNKNAKEVDFGVRMMMEGCQSEPMLTQGQQYEDDVKKAAIQLMYLSRAANT
The following text describes a protein:
Function:
Component of the 2,4-dinitrotoluene dioxygenase (DNTDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into 2,4-dinitrotoluene (DNT) to form 4-methyl-5-nitrocatechol (MNC) and nitrite. Functions as an intermediate electron transfer protein via a specific interaction with iron sulfur protein components (ISP)(DntAc and DntAd). Also able to convert naphthalene to cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene.
Sequence:
MSENWIDAAARDEVPRGRRDRHQYRRQGDCLYEVAGEIYATDNTCTHGAARMSDGFLEGREIECPLHQGRFDVCTGKALCTPLTQDIKTYPVKIENMRVMLKLD
The following text describes a protein:
Function:
Plays a critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has replication fork regression activity, unwinds stalled or blocked replication forks to make a HJ that can be resolved. Has a DNA unwinding activity characteristic of a DNA helicase with 3'-5' polarity.
Sequence:
MMSPETRKQLKITDVSAKKLDKLNLHTAWDLVLHLPLRYEDETHIMPIKDAPIGVPCQVEGEVIHQEVTFKPRKQLIVQIADGSGSVLFLRFIHFYASHQKQTAVGKRIRAVGEIKHGFYGDEMIHPKIRDAEGGGLAESLTPVYPTVNGLNQPTLRRIIQTALDVTPLHDTLPDALLCRLKLPHLAESLRLLHSPPPSFTIHQLSDGTLPAWQRLKFDELLAQQLSMRLARQKRIGGTAAALGGDGTLTQALRQALPFALTDAQEKVVSEICRDMAQTYPMHRLLQGDVGSGKTIVAALSALTAIESGAQVAVMAPTEILAEQHFIKFKQWLEPLGIEVVRLFGSLRKKAKDEAKAKLADGSVKIAVGTHALFSDGVAFHNLGLTIVDEQHRFGVAQRLALKNKGREVHQLMMSATPIPRTLAMSFFADLDVSVIDELPPGRTPIKTRLVNNVRRAEVEGFVLGTCRKGRQAYWVCPLIEESETLQLQTAAETLARLQTALPELNIGLVHGRMKAAEKAEVMARFSSGGLNVLVATTVIEVGVDVPNAALMVIEHAERMGLAQLHQLRGRVGRGAAESVCVLLFAEPLGELAKARLKVIYEHTDGFEIARQDLNIRGPGEFLGARQSGVPMLRFAKLEEDLHLLEQARETAPMLIEQNPEIVEAHLARWLSGREGYLGV
The following text describes a protein:
Function:
Esterase that shows preference for short chain fatty acids. Contributes to the growth of M.tuberculosis during the nutritive stress. Elicits strong humoral response in both extrapulmonary and relapsed cases of tuberculosis patients.
Miscellaneous:
MISCELLANEOUS: Was identified as a drug target.
Subcellular Localization:
Secreted. Note=Extracellular.
Sequence:
MAVRPVLAVGSYLPHAPWPWGVIDQAARVLLPASTTVRAAVSLPNASAQLVRASGVLPADGTRRAVLYLHGGAFLTCGANSHGRLVELLSKFADSPVLVVDYRLIPKHSIGMALDDCHDGYRWLRLLGYEPEQIVLAGDSAGGYLALALAQRLQEVGEEPAALVAISPLLQLAKEHKQAHPNIKTDAMFPARAFDALDALVASAAARNQVDGEPEELYEPLEHITPGLPRTLIHVSGSEVLLHDAQLAAAKLAAAGVPAEVRVWPGQVHDFQVAASMLPEAIRSLRQIGEYIREATG
The following text describes a protein:
Function:
Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.
Subcellular Localization:
Mitochondrion.
Sequence:
MCELYSKRDTLALRRKHIGPSCKVFFAADPVKIVRAQRQYMFDERGDQYLDCINNVAHVGHCHPEVVKAALEQMEALNTNSRFLHDNIVEYARRLSATLPEKLSVCYFTNSGSEANDLALRLARQFRGHQDVITLDHAYHGHLSSLIEISPYKFRKGKDVKKEFVHVAPAPDTYRGKYREDHADPANAYADEVKEIIEKAHNSGRKIAAFIAESMQSCGGQIIPPAGYFQKVAEYVHRAGGVFIADEVQVGFGRVGKHFWSFQMQGEDFVPDIVTMGKPMGNGHPMACVVTTKEIAEAFSSSGMEYFNTYGGNPVSSAIGLAVLNVIENEDLQGNATRVGDYLTELLNKQKAKHTLIGDIRGIGLFIGIDLVKDRQERTPATDEAQHVIYKMKEKRVLLSADGPHRNVLKIKPPMCFTEEDAKFMVDQLDEILTVLEEAIGAKSESVISENTPCRAKMPNEAHSELLGEGASDPRENPGQKRNGLCTDKHSLLSKRLKT
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MPPPADCGNPLLLKWLEEWVVEAQERGYKSLPALKKARDSMKACPMRFDHPSEAVCLNGLGEGLAKRLTDSLEKYCDEMGIAMPKKSRGKKRNSVAADVPGNGDDPASPSPSPKKVRKTKTYVPKLRSGAYAIMLALGTQPRNSRIGITKEEIIALAEPYSDHSFTQTRPSEFFTAWNSMKTLINKDFVYTKKNPATRYYLTDEGWDLADTIKASGDPTLGRAHDFQPAAPGPSSTSARNQDVDTDSELEEIDPQTRARPQANPNIPDIPEGDAVSIPTFEPIILRPGTFTVELILDNREVASKKDRDGIPNRLTDMGVAHSVRALPLGDFLWVARVREDKAKWLNLGKSNLIMLDYIMERKRLDDLIGSIKDGRYEEQKFRLKRSSITNVKYLIENKKIDADIMDKWGDGITTSIAKMMVQDGINVKQTLDLGESLRYIERMTKLLKKQYEGNPLYIVPTTVLTLKNYSPLMQHLRNTQPDREYSITFDAFEGLSNKSQNLTLKDVYLKMLMRTKSISAVKAIEIQKRWPTPRAFLEAFENLDGEVQADERGARGVGAGSAGNGMGMRIGISNEKPKNKGKGPAIILDSDEVSKKRKREMVSKEIGALVGNKKVQGALSAKIAEVWGGVF
The following text describes a protein:
Function:
May be involved in the modulation of rDNA transcription.
Sequence:
MSDQPAQSDLPDQGALPPQEAAQPQAVREDPQPQQCAQQVLFEQQGAQHRVYISNLSQDATEEALTEFLKDFHPVSVLIPSQSVRGFQKTSVRPLGIAYVEFKDADTAAKVILELNGVTFMDRELRLRYHIPFKSEKEKLARGPNKFRQIQRRLSELRRRNSDAGATVTTDNGPQVDAAAVPREMSKVTIYVGRLPGRTTDKDLRTYFHEYLPQEIIVFKHRQFRGWRIRRHVTAAVITFPDHERQESALESLSNLPFNGRTVRMAPAFEDKLAEIRAEVQRMAVEQQLPQPASNLGIYIGNNLIAMQPLQTRKADQQSLQSQHSPQNAAEDQTITAPPPSQQQLPQLQPIAPPLSLQPLNPVENTQPVQGLDLSIPREHEEVVRGQPLLRLQKLQMIQRLQRLHRQKQRQQIQQEPAAQPAAQPAAQPATEAAVAPQLVPEQEAHQAAAQAEPQQVLERPIAAGA
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSKDKKQVDPLKSFIAGGTAGAVEGIITYPFEFAKTRLQLISKSSTASRNPLVLIYNVAKTQGVSSLYVGCPAFVVGNTLKASVRFLGFDSIKNLLSDKNGKLSGPRGVIAGLGAGLLESVVAVTPFEAIKTALIDDKQSIKPKYQNGVISGSFKLVRDMGFKGIYAGVVPVSLRQAANQAVRLGSYNAMKTMIQQASGQKPNEPLSGTTTFAVGALAGIITVYTTMPIDTVKTRMQALGADKLYSSTLNCFVKIFKDEGLLTFWKGATPRLGRLVLSGGIVFLCYEKIMILLN
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MGTNAKVAEKTPCVDSGSLFKWWLNPSKIFRTPNRKLKNTTPVVVVGSGSHSGDGTTEFVKVATKKLLYFSYRNCFPPLPSGSTTDTHWGCLVRTTQMLVGTCLLRYHCKGAYVLPEADNAELKERISRLFMDVPSAPLGIHKAEDEAHKNSVKYASMLSPTEAGMAIAAALIAFRAQGGDVPFTFCCESRHIDEPAVMAKLLEGQHVVLIIPVVLGIAPMSDQYELVMLKILDVKACCGIAGGFKQASLYMFGHQGRSVFFMDPHYVQNAYTSSRTVGTLEGSRGELRARRFDPCMVLGFYLHTPEDYRVFAEELAVANSLVVFPLISFGRRPREGTTLSEDRVVSVAESAESITLHEKEKPQRSRNPLAADGEHARSSNSISSPPS
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTRWRTTTKTLRIIVIILWGKEGRCLSLRGKHSFLGESLPACLPASLHWSPCCRRGSFAAHPMPSLSGRSSSSPDGAARESRDAKGRGPATSARPPRGPRSQARRRGSHGHPRGAQAGTIPLHCQGNFYHGQLWAAAFGQGEIAFLEGLTIVYKSSIDLFFYVVGSPHENELMLTSVLSCLFESLNHMLRKNVEKRALMENLDGVFLVVDEIVDGGVILESDPQQVIQKLNFRTVPEPAPYGFVLLDYIVGNTEHSEILPEMFQK
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs (By similarity). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (By similarity). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity). Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSSFSTTERLAAKLKKPKEVYSYSITDGKVTMDQSQLKYYYLPEETILKAPIDLTKGIENWTQPNEHDTHLDTLLESLSKYERETGSKIDAEIITWRGILTKIMTHPYDQYNEPIVLNITYFDGHYFIEEDWQSKQQGKKAPDEQMKKHIYSGYKFESVALLNEPWFKSSREDIESRFDDIPNGDQFVSVVRTQIGDNKILIGGEVDCVFDPCAKGTSRYGELKTSREVHNAKDGEILERKMNRAWAQSFLLGVKHIIYGYRTGDHKLAAVDYFKTEDLPMYAGASSTWSGTDEINFLNAALTKLKDLPKEDNKLWRLVFDSANKKVDITELDGESFLLKEFVDWRKSM
The following text describes a protein:
Function:
Internal motor kinesin involved in trichome morphogenesis. Participates in regulating the formation of Golgi-associated vesicles. Plays a central role in microtubule disassembly via the active ARAC10-ICR5 cascade, which establishes the secondary cell wall pattern in metaxylem vessel cells. Acts redundantly with KIN13B to modulate cell wall synthesis and cell expansion via the THE1 pathway.
Subcellular Localization:
Golgi apparatus, Golgi stack. Cytoplasm, cytoskeleton. Note=Localized to cortical microtubules in secondary wall pits when associated with ICR5. The N-terminal region of the protein is required for its localization at microtubules, but the truncated protein can be recruited to microtubules upon interaction with ICR5.
Sequence:
MGGQMQQNNAAAATALYDGALPTNDAGDAVMARWLQSAGLQHLASPVASTGNDQRHLPNLLMQGYGAQTAEEKQRLFQLMRNLNFNGESTSESYTPTAHTSAAMPSSEGFFSPEFRGDFGAGLLDLHAMDDTELLSEHVITEPFEPSPFMPSVNKEFEEDYNLAANRQQRQQTEAEPLGLLPKSDKENNSVAKIKVVVRKRPLNKKETAKKEEDVVTVSDNSLTVHEPRVKVDLTAYVEKHEFCFDAVLDEDVSNDEVYRATIEPIIPIIFQRTKATCFAYGQTGSGKTFTMKPLPIRAVEDLMRLLRQPVYSNQRFKLWLSYFEIYGGKLFDLLSERKKLCMREDGRQQVCIVGLQEYEVSDVQIVKDFIEKGNAERSTGSTGANEESSRSHAILQLVVKKHVEVKDTRRRNNDSNELPGKVVGKISFIDLAGSERGADTTDNDRQTRIEGAEINKSLLALKECIRALDNDQLHIPFRGSKLTEVLRDSFVGNSRTVMISCISPNAGSCEHTLNTLRYADRVKSLSKSGNSKKDQTANSMPPVNKDPLLGPNDVEDVFEPPQEVNVPETRRRVVEKDSNSSTSGIDFRQPTNYREESGIPSFSMDKGRSEPNSSFAGSTSQRNNISSYPQETSDREEKVKKVSPPRGKGLREEKPDRPQNWSKRDVSSSDIPTLTNFRQNASETASRQYETASRQYETDPSLDENLDALLEEEEALIAAHRKEIEDTMEIVREEMKLLAEVDQPGSMIENYVTQLSFVLSRKAAGLVSLQARLARFQHRLKEQEILSRKRVPR
The following text describes a protein:
Function:
GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Required for chloroplast biogenesis. Probably specialized in the import of nuclear encoded photosynthetic preproteins from the cytoplasm to the chloroplast.
Subcellular Localization:
Plastid, chloroplast outer membrane; Single-pass membrane protein. Cytoplasm. Note=Cycles between the cytoplasm and chloroplast, probably as a soluble preprotein receptor. The anchoring to the chloroplast outer membrane required the GTPase activity and GDP, and is dependent of interactions with TOC33 as well as TOC34 and TOC75. May contain beta barrel transmembrane regions.
Sequence:
MDSKSVTPEPTNPFYASSGQSGKTYASVVAAAAAAAADKEDGGAVSSAKELDSSSEAVSGNSDKVGADDLSDSEKEKPNLVGDGKVSDEVDGSLKEDSTTPEATPKPEVVSGETIGVDDVSSLSPKPEAVSDGVGVVEENKKVKEDVEDIKDDGESKIENGSVDVDVKQASTDGESESKVKDVEEEDVGTKKDDEGESELGGKVDVDDKSDNVIEEEGVELTDKGDVIVNSSPVESVHVDVAKPGVVVVGDAEGSEELKINADAETLEVANKFDQIGDDDSGEFEPVSDKAIEEVEEKFTSESDSIADSSKLESVDTSAVEPEVVAAESGSEPKDVEKANGLEKGMTYAEVIKAASAVADNGTKEEESVLGGIVDDAEEGVKLNNKGDFVVDSSAIEAVNVDVAKPGVVVVGDVEVSEVLETDGNIPDVHNKFDPIGQGEGGEVELESDKATEEGGGKLVSEGDSMVDSSVVDSVDADINVAEPGVVVVGAAKEAVIKEDDKDDEVDKTISNIEEPDDLTAAYDGNFELAVKEISEAAKVEPDEPKVGVEVEELPVSESLKVGSVDAEEDSIPAAESQFEVRKVVEGDSAEEDENKLPVEDIVSSREFSFGGKEVDQEPSGEGVTRVDGSESEEETEEMIFGSSEAAKQFLAELEKASSGIEAHSDEANISNNMSDRIDGQIVTDSDEDVDTEDEGEEKMFDTAALAALLKAATGGGSSEGGNFTITSQDGTKLFSMDRPAGLSSSLRPLKPAAAPRANRSNIFSNSNVTMADETEINLSEEEKQKLEKLQSLRVKFLRLLQRLGHSAEDSIAAQVLYRLALLAGRQAGQLFSLDAAKKKAVESEAEGNEELIFSLNILVLGKAGVGKSATINSILGNQIASIDAFGLSTTSVREISGTVNGVKITFIDTPGLKSAAMDQSTNAKMLSSVKKVMKKCPPDIVLYVDRLDTQTRDLNNLPLLRTITASLGTSIWKNAIVTLTHAASAPPDGPSGTPLSYDVFVAQCSHIVQQSIGQAVGDLRLMNPSLMNPVSLVENHPLCRKNREGVKVLPNGQTWRSQLLLLCYSLKVLSETNSLLRPQEPLDHRKVFGFRVRSPPLPYLLSWLLQSRAHPKLPGDQGGDSVDSDIEIDDVSDSEQEDGEDDEYDQLPPFKPLRKTQLAKLSNEQRKAYFEEYDYRVKLLQKKQWREELKRMKEMKKNGKKLGESEFGYPGEEDDPENGAPAAVPVPLPDMVLPPSFDSDNSAYRYRYLEPTSQLLTRPVLDTHGWDHDCGYDGVNAEHSLALASRFPATATVQVTKDKKEFNIHLDSSVSAKHGENGSTMAGFDIQNVGKQLAYVVRGETKFKNLRKNKTTVGGSVTFLGENIATGVKLEDQIALGKRLVLVGSTGTMRSQGDSAYGANLEVRLREADFPIGQDQSSFGLSLVKWRGDLALGANLQSQVSVGRNSKIALRAGLNNKMSGQITVRTSSSDQLQIALTAILPIAMSIYKSIRPEATNDKYSMY
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLSLSPILLYTCEMFQDPVAFKDVAVNFTQEEWALLDISQKNLYREVMLETFWNLTSIGKKWKDQNIEYEYQNPRRNFRSVIEEKVNEIKQDSHCGETFTPVPDDRLNFQKKKASPEVKSCDSFVCAEVGLGNSSFNMNIRGDIGHKAYECQEYGPKPCKTQQPKKTFRYHPSFRTQERDHTGKKPYACKECGKNIIYHSSIQRHMVVHSGDGPYKCKFCGKAFHCLSLYLIHERTHTGEKPCECKQCGKSFSYSATHRIHERTHIGEEPYECQKCGKAFHSPRSCHRHERSHTGEKAYQCKECGKAFMCPRYVRRHERTHSRKKLYECKQCGKALSSLTSFQTHIRMHSGERPYECKTCGKGFYSAKSFQRHEKTHSGEKPYKCKQCGKAFTRSGSFRYHERTHTGEKPYECKQCGKAFRSARNLQLHGRTHTGEKPYQCKECGKAFRSASQLRMHRRIHTGEKPYECKECGKAFRYVQNFRFHERTQTHKNALWRKTL
The following text describes a protein:
Function:
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as a costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MLQLCFLFVGLTVGTANKADPVSVRLGAKDPPCEGAVEIKSRSEWLPLCKDSLNVIVSGLICKSLHCGNAKEQSPVSTVTNSSVYVTIECPTAKSLSHCTLSHVPAGNCSALAMINCKEPPSLKLVGGGSPCAGRVELLLDKVWGSICDDGWDALDAQVTCRQLGCGLPLQVLGGSHFGSGPLKIHRDEMNCDGTEHFLWECPANESHDCLAGEHAGVICSEHQAVRLNGGPDGCSGRIEVFLKGVWGTVCNSHWDDEDSDMLCKYLECGSFVKKSIYNHSLSTYMAFICQQQVKSPWDCRIHDKNRNICQNEGAVGLLCNGSLVVESTTQQRETVTLPTPAIPALRLPLFYVCIGLLVLLLLLIPGFFLMIWKLRRRQGISHDHSPSFPVTTLSDPSVSAQNKWSGVPTATPAMVLTPMNEYNDSVPVRGKQPVPVQIPVVPQAVQVLQSDDDDYDFCSTPPVALSSFHDPALRRDVRQRGAGAEEQDCVGRQESHETHRSSSTSSEEQSWYENYRGQNQGYQELVRPPQSHASSSDYDDVSSNASCKGPKITSH
The following text describes a protein:
Function:
This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
Sequence:
MGISYSVDVDSEASAKAMLRERSISLKHSKAIAREISGETVADAKEYLQAVIDEERSVPFKQHNSGVGHRNDIDGWDAGRYPEKASKDFLKLLSNVSNNADQQGFDADEMVIEHVAPHKVGESQGRKPRAMGRATTWNATLCDVEIVVTETEEVTA
The following text describes a protein:
Function:
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Subcellular Localization:
Nucleus.
Sequence:
MTMDEFHPFIEAPLPHVKSFAYTWFNLQARKRKYYKKHEKRMTPEEERQVKEELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLSVTGKKPPSCVMSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSANCTHPTICVQPHHISISVRELDLFVAGYMQQHENTGSDSGDSMSVSSDPDIKDPARWIPASGILTRTGLAREGHCHSNGVDPSRAKPTYSHPWEPNSQHQRGKFMGAPIVQGGGVGNLTIGDLESPTYYSMPPEQPMSAGMAIRRSLQTAPRSIKRPKRNAGSLSSVDDDADSIGEADGDVSFYGRSPASLGSQSSSWQSDIEPGTSPALPSPNVIHAKPKPSDKPGNFGSPASTGGAPTTTATTPAAMHALPHPVLLTGPGGAVYPTALAFSTAGSFQQPGGYYQHPLRFHHNPESNTLADFVQVVCNQEAQNQESYAHGTRETWVKLERSVPQVCKNENKFNPSKCSPGPFIPATMLPPPPPPPMARPVALVTSGARSTTSATPSPTTSTTTSSAASAPGSTCPTTPPGNRAIMTSPFAALGRPETGFIHPQAQHQLLTYPNISPVSMTALSPSVLASPMTTPRTTPRSTPIPRWTAPLISLEENADYNMMAGMVQPMNPEEGMLNEERFFPMMPSEPMDTTANSSTQTSPTKEAAA