lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1. H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and maybe H3K79me. It thereby plays a central role in histone code and gene regulation. Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBC2/RAD6.
Miscellaneous:
MISCELLANEOUS: HUB1 and HUB2 are involved in the same processes, but are weakly or not redundant; MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
Subcellular Localization:
Nucleus.
Domain:
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Sequence:
MENQESDEPMQKKPHLLDSVSPNSMARNSSPSHPIAKSVSFFDCDFSLLCLRLVDYEIDVDATVLQLQNQKLVQQLDLQKKQLYDVESKIQELQLNQTSYDDELISVNQLWNQLVDDLILLGVRAGANQEALNYLDIVDKKRVPPCAADETFLCRLLQVDSLDTSKSDEVVRKVEEALALRHSSTMELMGLFENTIDTQKTKAESISQSLHAVKSTEDATIQLSSINDLMKEESKNLREMIDALHVRHKEHSEQIQAYISSHSTDQSELKHLKGQLEEIKAELEENRRKLITLKMQKDAACEGHVTSPAIANGSLSPEKPVDKTKLRELKDSIDEIKIMAEGRLSELQASQEYNLSLSRQCQDIENELKDDQYIYSSRLYSLINDRIHHWNAELDRYKILTEAIQAERSFVMRRDKELNLRAESLEAANHKTTTVGSRIEVLEKKLQSCIIEKNGLELETEEAIQDSERQDIKSEFIAMASTLSKEMEMMEAQLKRWKDTAQDALYLREQAQSLRVSLSNKADEQKGLEDKCAKQMAEIKSLKALIEKLLKEKLQLQNLASICTRECNDDRGLAEIKDSQRKAQAQAEELKNVLDEHFLELRVKAAHETESACQERLATAKAEIAELRTQLDLSEREVLELKEGIKVKEQEAEASIAEMETIGQAYEDMQTQNQHLLQQVAERDDYNIKLVSESVKTKHAYNTHLSEKQVMEKQLHQVNASVENFKARIAHNEEQMKGCFSEAYKLIQEDRHLVISLETTKWEVADADKEFRWLKSAVSSSEKEYEQISRRTDDIKLELDDERREKKKLEEELMELNKELEELGSESVEAAIVRLQEEVKNCKNILKCGVCFDRPKEVVIVKCYHLFCQQCIQRSLEIRHRKCPGCGTAFGQNDVRLVKM
The following text describes a protein:
Function:
Required for activity of the M3 pharyngeal motor neuron.
Miscellaneous:
MISCELLANEOUS: Can substitute for ems in D.melanogaster ems mutants, partially rescuing the mutant phenotype.
Subcellular Localization:
Nucleus.
Sequence:
MTLKFSVERLVDSEKESEEADVEEQNNLKKLEEDEEDDELCEKSGKNEPLSQTLSYFDVLLPHVQMACSNPFISGIGASGSGDQNLNTGAGGSVWQHPWLELLQSTTAAQFGDVTAGLFLQPLRKNKRIRTAFSASQLIQLEKAFEGNHYVVGNERKQLAAKLSLTETQVKVWFQNRRTKHKRVRLEGSDPNAPMSNDEDDEDDKKSVS
The following text describes a protein:
Function:
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MNKGTIVKLHSLNLDRNINKNVAFNRKGINNYESDLSISSYKTFKNSSDNNDIPLYRTCTNDSDHSIKNKDIYGYKKVVSLNEYIFKFKKLTNEKNKNTLDKCNIFRRFNTNQNNLINISDSCSESNLSSEGNVSMGVATNMMKKKKIRQNINEGMEDIFCLYDKGKHFNYNNYDTIKDITKYKSHIQMEDKPLSCYLNSSFKLMSDNLNCDEKDNTKKTSFQIVNDVIWEKRGLITCSNGYILDRDVIKNSEEKKSLKKKVKKYFKHKKSFLQSVKKKRIKKYKTVLYNSIHNENKIFVRNPRLSIRDINLYNIKHGKKKNKRIFVFLNGINNIYHSFRRKNQNYICNNKNKTCIIMKYNIRNDFINSYEKHLNKKIDNNIFFEIEQNNIKHDIDDNIKKPNVEYIKDELNNKESISFYELHKNKNIIIGKRNIIFPSCYMKCDKAKIVIGENNLFEDLVTIINNTSTDMYIGSYNIFRSGTYIYNSMKIGDRNCFDYKCNIIKSNIGSHTFIGINMMIDKKWRLRNDHKIVDNVVIYLNSQIIQENMREIISRYNQIK
The following text describes a protein:
Function:
The glycine cleavage system catalyzes the degradation of glycine.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRSIRLIQRVANFSRLANPHEVNPKVPDWFKSSDYMEPRFIGSESQQVNEMLKAVEAKSLDELVDKIIPKEIRSEAAFQSPDNFPDAIPESAMVQHLQSLANKNKLYKNYIGQGFYGTHTPYVILRNVLEDPGWYTSYTPYQAEISQGRLEALLNYQTVITELTGMDVSNASLLDEATAAGEAMFLANSWFEKKKFFVDNHVFPQSIDHIKTKAYYLGIDIVVGDAKTYDFKDADQYCGVLVQSPDNLGEVHDWSDLFKHTLKDAKLLKVIGTDLLSLAINKTPKDQGANVTYGNSQRFGVPMGFGGPHAAFFAVEDEFKRKMPGRIIGISKDANGKSAYRMSLQTREQHIRREKATSNICTAQALLANMAGFYATYHGPQGLQKIANRVNCLARSFAKLAKSLGLVVKEGRIFDTVVLHNTETLQEYLHYNAQTNVRKIGQDTIFSFDETHTVQDVEDLFNHLQHYTKKKADFMSVIQKVIPYKSERAPFLQQKVFNSLHSETEMLRYINYLRQKDVSLTKSMISLGSCTMKLNPTSFMLPVSFQGFSQLHPFSPLSCTQGYQELTENVEKWLCDITQLEAVSLMPNSGAQGEYTGLLCIRKYHIMNGQKDRNICLIPISAHGTNPASAVLAGLTVVPVNVVDGYVDLNDLNKKIKENEKSLACIMITYPSTYGVYEDQTKKIIQLIHEHGGLVYMDGANMNAQVGYTSPGYLGADVCHLNLHKTFSIPHGGGGPGLGPIAVNKKLAPYLPGREHSLGSVASSLFSSASILPIPYSYFGQLGRQGAKKCTAMAMLNANYLMKSLKDDYKVLFTGQNGMCAHEFIIDIRPIKQESGITEEDIAKRLMDYGFHAPTMSFPVPGTLMIEPTESESKSELDRFIEAMKNIKLEIEKVKNGQYDKNDNPLKNAPHTQDQVINSGWSHKYSREEAAFPLPYVLQRGKVWPTVSRINNAFGDRNLICQCPSVSDYQQ
The following text describes a protein:
Function:
Transcription factor involved in the regulation of the circadian clock. Acts as a repressor of CCA1 by binding to its promoter. No binding to the LHY promoter.
Subcellular Localization:
Nucleus.
Sequence:
MADNDGAVSNGIIVEQTSNKGPLNAVKKPPSKDRHSKVDGRGRRIRMPIICAARVFQLTRELGHKSDGQTIEWLLRQAEPSIIAATGTGTTPASFSTASLSTSSPFTLGKRVVRAEEGESGGGGGGGLTVGHTMGTSLMGGGGSGGFWAVPARPDFGQVWSFATGAPPEMVFAQQQQPATLFVRHQQQQQASAAAAAAMGEASAARVGNYLPGHHLNLLASLSGGANGSGRREDDHEPR
The following text describes a protein:
Function:
Hydrolyzes acetyl esters in homogalacturonan regions of pectin. In type I primary cell wall, galacturonic acid residues of pectin can be acetylated at the O-2 and O-3 positions. Decreasing the degree of acetylation of pectin gels in vitro alters their physical properties.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MGKHVQIMADHRSKLLVCVFLVLTTQTLSELTDKINITYVNSAVEKGAVCLDGTPPAYYHSVGFGDGADNWLVYLEGGAWCNSTETCLERVKIKWLASTSTRPAIRYVSGIFTVNQTFNQAFYNWNKVIIVYCDGASFTGDVEEVDPTTNLHYRGARIFRAVIDDLLAKGMKNAKNAVLTGSSAGGLATILNCDRFRSLVPHATRVKCISDSGFFIHSKNMPGANEREAYFTQVAELHGMAKALPQSCASKMNPGLCLFPEYVIKDMQTPLFILDSLFDLYQIKEMLAPFVGGCKEQWDDCTTNLTLCTSSQLQIMKDHRTAFLETLQEVESPSLGIFVHTCFLHTHVLDKDGWRCSFVARNVLAKKTIEEAIDDWYYDRSSFQQIDTYTTVPRNCTVSRDNDIMNQRCLHPKHVHPMY
The following text describes a protein:
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Sequence:
MDQLKHTLAGLGEFAKENLPPQVTGTVTDLTSSVRSRLTLGSRRRTQPIDDEEAGDIIPLDAHAGGGHSTCKHGPQLRVSPALQSFIARNHILSSGETVADLLAKSHIAVPREVINRDYPLPEYFVSSSHNTYLCAHQLFGESSTDPYRHTLQAGSRCVEIDVWDNPDNLDEPKVTHGYTLVSNIPFREVCKIILQVVEEEEESGGGGGGGAPVLISLENHCGAQGQEALVRIMKEVWGRHLLDKPVETESHIEQDQHVRLRDLGSKIVVIVEHHLVNEASSDSSSDSSSEDEAEKKERKQRKQAKKDTPEAKLIIPSLAELGVYGQSVKPPDNSWFTSSDLLPSRDGPHHHLINVSESGLNALLSSGNGASIAKHNARHLMRVFPKGTRISSKNLKPLPFWGLGAQVCALNWQTFDASMQINEAMFAGTGGYVLKPSWLRSSAAMVGLAEKEFREQVARTRRRKRLSLVVAGASDVPVPSGRDTDKELKPYLTCTLLHPGVPFGEMQQTKKKTDVFRKHKLSALLIGGLTGAASKEEENSLVTDPVWDETLEWDEYEDDELVFLRMFIKSDDSFSSNPVLCVASVRLLYVEGVKGQWRFVRMLDLKGRETACTLLVKFEVDEL
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MVEVEEIELDLALSIGGSFGKYTVEKPAPDSEARVSNSDSRDGMRVVMEPREKREIQAFRRMEARKKRERLREPSEPESQLRDFKREKTECGNGVSGSWTAATTTPYRMHQFATVQYLPLNNGFPLPCWVGGEKNVGGVDGVDGINGGGDRKAKSNGSSRCSSSVVSDYQSSSREEGGSTDSHSHSVHSLAEPAQLNTSKEISIGTSQPEESASASSHPIRPKQGNTTIQEIKKHIAKETRPKPNPNSPEPIENKPLSNENLTKVEIMGKPPKPLSHTSYSLPPMPYVSTKGDNGRTVNGFLYRYTKSEVSIICVCHGSTFSPAEFVQHAGGTDTTHPLRQITVIPSVFG
The following text describes a protein:
Function:
Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose. Known targets include Notch proteins and coagulation factors, such as F9.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MRNSPVGEKAAKDMAWRITSMRALHGVLLLAAALAVFAFYYLGSGRENFSSTTKRIKENWAAQSTSTEVDLASSSELKLSEKGKILESHGPLDYHLLMMFTKVHRNPGLQDKFQVALSSLVKYGKFESNEVLCLHFVSDEPSKEIGKALLRDLLQGASFKYKVIFHDVTTLTEKLFPIVEAMQKHFSSGSGTYYSDSIFFLSVALHQIMPKEIYRIVQLDLDLKFKTNIRELFEEFDNFMHTSVIGIAPEMQPVYRHTFWQYRRENPLTKVGDPPPDGMPGFNSGVMLLNLEAMRLSKLYNELLEPNAVQQLAEKYHFKGHLGDQDFFSMIGMEHPELFYVLDCGWNRQLCTWWKDHGYMDVFDDYYRCEGHIKILHGNCNTPIPDE
The following text describes a protein:
Function:
Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MVAQRYTLSALRSTLSAASSAPRQSVATSSRTFASTPYNRSDRPPTGSFSPHQNDASSASTSSTNAFSSSRPAATFGMDGSASDHKQTHFGFKTVAEEEKESMVASVFSSVASKYDVMNDAMSLGIHRLWKDHFVSKLDPRGGIKVLDVAGGTGDIALRILDHARTKHFDRETHVTVLDINPSMLKEGQKRFKQTMYWGGPQVSFQLGNAEQLDSSMSVPAEPVRGPNSKHPYLPPLESKPIPDESIDLYTIAFGIRNCTHIDEVLRQAYRVLKPGGVFSCLEFGKVNIPFLAEAYKQYSFNVLPPLGQMLAGDRASYQYLVESIERFPTQPQFARMMKDAGFHLPGSPTATNLGFPAESGSAAGSEDVAGAWEDLTFGVATIWTGIKL
The following text describes a protein:
Function:
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
Subcellular Localization:
[Isoform 1]: Nucleus, nucleoplasm; [Isoform 3]: Nucleus, nucleoplasm; [Isoform 5]: Nucleus. Nucleus speckle.
Domain:
The HIN-200 domain mediates interaction with MDM2.
Sequence:
MANNYKKIVLLKGLEVINDYHFRIVKSLLSNDLKLNPKMKEEYDKIQIADLMEEKFPGDAGLGKLIEFFKEIPTLGDLAETLKREKLKVANKIESIPVKGIIPSKKTKQKEVYPATPACTPSNRLTAKGAEETLGPQKRKKPSEEETGTKRSKMSKEQTRPSCSAGASTSTAMGRSPPPQTSSSAPPNTSSTESLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHLKTPQMPPTTPSSSSFTKKDETHPGAQSSPANFRITSPTVAPPLSSDTSTNRHPAVP
The following text describes a protein:
Function:
Transcriptional repressor that may regulate multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing OFP17 have no visible phenotype.
Subcellular Localization:
Nucleus.
Sequence:
MRVKATLINFKSKLSKSCNRFVSLFRFRVKRPVFIRPLRARHGNVKPRHQHHHSKKPICSCLCFLNSSKNHKMSNAKHRSSSFSVNDDDYSKFMQSPLTPATAKKLFTSPITTPYSSRTRKSLNARDTFEDNAVEDACRSFENYLIHLIVEEGKIDDLMDIEELLFCWKNLKSPVFIELVSRFYGELCRDLFSGE
The following text describes a protein:
Function:
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to the ciliary transition zone.
Domain:
The 2 PHD-type zinc fingers are required for transcriptional activity.
Sequence:
MKRSRVPSTSEDSDNGSNSTSWSQHSNSKHRKQSGKRPSEVFRTDLITAMKLHDSHQLNPEDYYELADPWRQEWEKGVQVPVSPESIPQCAVRTVAEKSTAPLFIKPKKLIRSSESSMLGYVGIQTLADGMCRYDLNEEDVAWLQITNEEFSKMGMQPLDELTMERVMEEFERRCYDNMSHAMETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGIFPKCHLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGNPEKMEPITNVSHIPSNRWALICCLCKEKTGACIQCSAKSCRVAFHVTCGLHCGLKMNTILTEADEVKFKSFCPKHSGLDWNEEEGDDDRPVKVPTREDRSRNRGIDFSASSQTRLSQNPEETRLSERKLRVQQLEDEFYRFVAADEVAEHLQLPLEMVDILFQYWKLKRKVNFNQPLIMPKKEEEDSLARREQEVLLRRLRLFTHLRQDLERVRNLTYMVSRRERIKRTLCRVQEQIFHHHVRLLEQGRVTGVSSTRRLEEAMFYFRTTPPVPASPQPLKGHCGQNSTLSSSEKGSNSYRSSKHIEADKPAKMLMDGVPSSGDSVRSETVMSASSRRSEGRTRSGESHRKEEESERPLEDRRRKSKLWDQVSIKDKLRHAKSMEDTLSSETELDTMDDRLLLSHTNANSVATAPNMYSGSPRKTNASHQGKLVPNGTSGRHLKNWGSFRIPKRSERTSAGRQTERQEADNTADQNSSLKTFSTSPSSPQIRTRLRTGSENRRHLEESDLGQSEQGKRCHTQRLPSPMTRRYGSDVIQRGVLAS
The following text describes a protein:
Function:
Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
Subcellular Localization:
Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MPYTYDEFRFCSVTPANKGLERNREKGKRLGRTLNLTEKQQQSILTELNTRSLEQLKATKYIGKNKAEALIQHRDQHGLLSSLQDLSGVRGFGKAFYDRLEKAGELPPITQKFSRQMEVIKTLLPEGALQKVDSIVSIDIGLQNAAWTHIDRDCQVLAWKQVHITRPKPYNPAILRPQIQKFVDSLPAADAHVIEMQSHRVGKHAAALLPFVIHLRIVESMLHCLLPSPCIPFDPHYTSKVFALPSGHTKKKKAAISLVESLFQENKPNPIEEECENFLKEQSGLQGSKDIVRNLVEGVEGGIINESAEDTSGDEENVGHPPAELDCSIRIPEELISYFELCKKKDDLSDSLLQALAFFHLIKQA
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. This activity may require prior 2'-O-methylguanosine modification at position 1370 (Gm1370) by MRM3. Essential for late-stage assembly of mtLSU required for efficient translation of mitochondrial DNA encoded proteins; methyltransferase activity is not required for this function. Essential for mitochondrial respiratory function.
Subcellular Localization:
Mitochondrion.
Sequence:
MAGSLKLVWASLQRQRFHTTGSCYKSRTGAEHLWLTRHLRDPFVKAAKVESYRCRSAFKLLEMNERHQILRPGLRVLDCGAAPGAWSQVAVQRVNAAGTDPSAPVGFVLGVDLLHIFPLEGATFLCPADVTDPRTFRKIQELLPGGRADVILSDMAPNATGIRSLDHDRLISLCLSLLDMVPDVLHPRGTFLCKTWAGSQSQRLQKRLTQEFQNTRTVKPEASRKESSEVYLLATQYRGKPGGL
The following text describes a protein:
Function:
The pigment-dispersing hormone causes the migration of the distal retinal pigment into the proximal end of the pigment chromatophore cells and thus decreases the amount of light entering the retinulas. May also function as a neurotransmitter and/or neuromodulator (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MRFIILGVLFIAVASMILSNGVMAQSRDFSISEREIVASLAKQLLRVARMGYVPEGDLPRKRNAELINSLLGVPRVMSDAGRR
The following text describes a protein:
Function:
Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2.
Sequence:
MAAIYGGVEGGGTRSEVLLVSEDGKILAEADGLSTNHWLIGTDKCVERINEMVNRAKRKAGVDPLVPLRSLGLSLSGGDQEDAGRILIEELRDRFPYLSESYLITTDAAGSIATATPDGGVVLISGTGSNCRLINPDGSESGCGGWGHMMGDEGSAYWIAHQAVKIVFDSIDNLEAAPHDIGYVKQAMFHYFQVPDRLGILTHLYRDFDKCRFAGFCRKIAEGAQQGDPLSRYIFRKAGEMLGRHIVAVLPEIDPVLFQGKIGLPILCVGSVWKSWELLKEGFLLALTQGREIQAQNFFSSFTLMKLRHSSALGGASLGARHIGHLLPMDYSANAIAFYSYTFS
The following text describes a protein:
Function:
A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are subsequently ligated to produce recombinant products; Hjc, Hjm (Hel308) and PINA coordinate HJ migration and cleavage of replication forks in a coordinated way.
Sequence:
MNAKKRKGSAVERNIVGKLRDKGFAVVRAPASGSKRKDPIPDIIALKSGVIILIEMKSRKDKEGKIYVRREQAEGIMEFARKSGGTLFLGVKKPGVLKFIPFDKLRRTETGNYVADSEIEGLDLEDLVRLVEAKVSKTLDNFL
The following text describes a protein:
Function:
Probably involved in cell-wall metabolism (By similarity). May have autolysin activity.
Subcellular Localization:
Secreted.
Sequence:
MKKIEAWLSKKGLKNKRTLIVVIAFVLFIIFLFLLLNSNSEDSGNITITENAELRTGPNAAYPVIYKVEKGDHFKKIGKVGKWIEVEDTSSNEKGWIAGWHTNLDIVADNTKEKNPLQGKTIVLDPGHGGSDQGASSNTKYKSLEKDYTLKTAKELQRTLEKEGATVKMTRTDDTYVSLENRDIKGDAYLSIHNDALESSNANGMTVYWYHDNQRALADTLDATIQKKGLLSNRGSRQENYQVLRQTKVPAVLLELGYISNPTDETMIKDQLHRQILEQAIVDGLKIYFSA
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MARCIVAAASVSALVPYTRAAFSCSSHRCLYRLQSACGSNIWTVETIGFNLRCVPGARRRFSASGIRAEGGGEDAGGFWAEKGITWRSLGLDGEVVGALMRAGLPHPSLVQAAAIPSILGTGDVVVAAETGSGKTHTYLAPLVQKMWKAGASGIEDAEDKEKSPFEGLGFGLGLVLCPNALLCHQVVDMANALRGEDGQPLVRVDMISGGQGWPTYLPDVVVATPAALLNNLFGFDANRRRRIAFVKAVRMVVFDEADMLLGGGFVRDVGRLIDLFRLEEKRISKLRELEASVETKIEFKEPEFRRVWSEAEGQEEAGDVAEEVEREAQEIVDESGNSLLFEQRAQESTASSGQSASMQRRSEWLRNRKEYKRSKQYIFVAATLPQAGKSSPGAVLKQKFPAMTWVHGNFLHRHNPMLEHRWVHVNKDNNLLSVLTDALRESRSNARTLVFANSVEGVDAIARVLDQCGLKCMRYHRDLSVEDKAAALSSFEEEGGTLICTDAAARGLDIPNITHVIQAEFATSAVDFIHRIGRTARAGQPGFVTSIYTDANLTLVNAMRDAMTAAIPVEGAFSRKRSLRRKVKKYGSYEDAQKAKSALTKQ
The following text describes a protein:
Function:
Transcription factor involved in endoplasmic reticulum (ER) stress response. Acts as a ER stress sensor and activates the transcription factor BZIP50 and the chaperone BIP1.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus.
Sequence:
MAIAEASPFADLPFPDDLPEFPHGPGGVGDDAFGLDGFNLDDLDIDFDFDLDLDLLPTDDVQLPSSPPPLATSSSSAGSPGGGGGGDSSSGSGGGADGGLKNDESSETSSRSASAGSDGKARDGVEGEDVKRRARLVRNRESAHLSRQRKKQYVEELEGKVKAMQATIADLSTRISCVTAENAALKQQLAGAGGAGVPPPLPMYPGLYPLPPPWMHPAYAMGARGSQVPLMPIPRLKTKQPASAAAEPPAKKSRKTKKVASVSLLGLLFLMMLCGCLVPAVNRMYGAVDSREGIVLGPSQSRHGRVLAVDGPRDSVSEGVDSELPHNSSQTLPVLLYIPRNGKHVKINGNLVIQSVVASEKASSRMCHSDGKSSCNQGQEDTSLAIPGHVAQLNSGEVMESAKAIKNKLMALPAGDGSIYREDDELLPQWFSEAMSGPMLSSGMCTEVFQFDISPTTIVPVYSSAMPNTSHNSTENVPSSQSHKVKNRRILHSMAIPLKGSTSNHTDHLKAHPKNESFAGNKPASSVVVSVLADPRVDADGRISSKSLSRIFVVVLVDSVKYVTYSCVLPFKTHSPHL
The following text describes a protein:
Function:
May be required for stable YIPF1 and YIPF2 protein expression.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Note=Evenly distributed between cis- and trans-Golgi apparatus. Mainly localizes within medial-/trans-Golgi and trans-Golgi network (TGN), while less so within cis-Golgi.
Sequence:
MAEAEDSPGEQEAAASKPLFAGLSDVSISQDIPIEGEITIPSRARAQEHDSSTLNESIRRTIMRDLKAVGRKFMHVLYPRKSNALLRDWDLWGPLILCVTLALMLQKSSIDGKNDGGGPEFAEVFVIIWFGAVTITLNSKLLGGNISFFQSLCVLGYCILPLNIAMLICRLLLLAGQGPINFMIRLFVVLLMFAWSVVASTAFLADSQPPNRKALAVYPVFLFYFVISWMILTFTP
The following text describes a protein:
Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Sequence:
MPVSSGSSACYTCDPFRSPKIRSSVFRDGAYGRLHFDLRDRDFFIYTPYRHVAHLTDLAPEEAHRVLLEIDRMIGAMTDSFNVQYNKGRWKSHEHAHMKVTIDEPTFRRIKRDHLSACERSLPPPLCGAERMPSWESRAWREHVREPLTRDCWVADAVEGPIVRRSITFNPGLYKIFDEALVNVIDHSKRDDALTYVKVSVDGGRVRIKNDGTPIPVVKHHQMTELYVPVVVFGVLLSGNNFDDSRERYTGGRNGLGVKLANVLSKRFEIEVVDAERRLKLTHAWRAGMDTKAADTKVKRLADSSKERSSVTVTFVPDFEYFGEAGETFSEDTVALFRRRVMDAAGCTPRPSISFDGKTIKVKRFADYVRLYVSSVAFVEHVAGPWRLAVCRAPEGFGYSHVSSVNGVSTALGGTHVDAACTALMRAMTPVLKGSERCVPALRAALFLMVHVDVANPSFSSQSKDACNTPASRLPRLDLPPELAKRVADRLKLRDVVADAERASDKRLLASTNGFKSGASTLKIPKLDDAPRAGTRDSHRCTLLLTEGDSAKSFAVAGVGALERKEREYWGVFPLKGKLLNVSEASAKQLAANAEVTRIQKILGLKHGAAYDSLRQLRYGKLVVLADADSDGFHILGLIIHLVETFWPNLIDLGFVCSMRTPIIRALPTAGKGSCLEFFSERAFEEWLDDEKKRRFKIRYYKGLGTHTAAEAKAVFARMDLVRYTRDAEGHRSMELAFSGARSDERKGWIVAATETPPRELTGPQMSLTEFVNNDLVRYGLAASERSLPSVWDGLKPSQRKIMFTLLESPAADEIKVAQLAAKVALRTVYKHGETSLANAIVNLAQDFVGAGNVNLLQPIGCFGTRLLGGKDAASPRYIFTKPSAAAPLIFRREDAPLLRPLTEEGASIEYEHLAPVLPMLLVNGCNGIAWGFSTNIHPREPAAVLANLRLLLERGSGATLAPMPPFWRRFRGTVEGAGAGGRWVVRGTFARLRENALRVTELPVGTWTESYKTAADGIEGVARVHTSSTEEDVCIDLVFESEDALSALLEGDPERTLRLRRSVDDDNMYAFDARGVIRKYASVEKMLREFFDARLELYGARKARSLADLQEELRAKRDQRAFVDAVVSGRIAVWRRPAEDVVEDILKVASGAGRTEARDMLKMQLASMTAEKLLEMTHKIDALETQISSLTEKTPQQLWHADLDALEKYL
The following text describes a protein:
Function:
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.
Sequence:
MINSNFVEGRKSIGGLGGFGACSIKVKNKVNQKCFFNCWRFLRGVWSVSSQTTSYGQQRRPYCLSDFTWCEARVFEARPITTTTESPRQTGPQARNSGKDAVPPVKRRWVPPSTLRRQDALTPESRNDLVFRKVRGILNKLTPEKFQKLSDDLLRIELSSSVILKGVILLIFDKALDEPKYSSMYAQLCKRLSEEAPNFESDGSTCTFRVLLLNKCKLEFDNRAAALESISSGLNDEDEERRQVAKRKMLGNIKFIGELGKLEILSEGILHRCIQELLVRRGDDPSEDLECLCQIMRTCGRILDTDKGQKLMEQYFDRMKLLAANTDLQPRIRFMLKDTIDLRHNGWVPRKATVVEGPMPINQIRPADDDRPGFRRDRNNHDRDSDRSNLSELFRHPMKTRSGIDDMIMSMNLTTSSPNLIPTNTFGTNGFGNQRDGGFRGHNNQRSGGYNNYNTNQRGQYKHNQNNANSQYNNQSNKEIAPRFKKNFIMPKEEIEDVELRPTTMLFNKASVKTNNMMNSRSIEPSYTQSMKQPPATLHKEPLPIKQVSSEKPKQSKKDKGPTKDEVLKRFGSLLDEYWKGDIDLKQAVNLYKEHKVPDKFAKDVMLHGLSIAVDKSDVEQEKLIKLLSNLKEENAVNTNTLQDTFKSLCNILDERENEIEKTTNAIAYLFSVAISEHLTLLSEVASLTDNGAHYPLFLVVLQHLHQKRGKPELTELFNKSKVNLLTQLPESDKTKERLSEILEERDLTFLYPLLRIQAELARQLNVDPNPQSYYKWIKENLDPANFNDPGFINALMTVLLKYITQEAAASGDDKAVAEKEKSMLERYQPILHAFLREKLHLQLVAVYSLQVHLYSLNFPKGQLLRWFMALYDLEIVDEEAFLNWKEDVTDAYPGKGQALFQVNQWLTWLQEAESEEEEGED
The following text describes a protein:
Function:
Catalyzes the oxidation of cytokinins, a family of N(6)-substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group (By similarity). In association with CKX3 regulates the activity of the reproductive meristems, flower organ size and ovule formation.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MNREMTSSFLLLTFAICKLIIAVGLNVGPSELLRIGAIDVDGHFTVHPSDLASVSSDFGMLKSPEEPLAVLHPSSAEDVARLVRTAYGSATAFPVSARGHGHSINGQAAAGRNGVVVEMNHGVTGTPKPLVRPDEMYVDVWGGELWVDVLKKTLEHGLAPKSWTDYLYLTVGGTLSNAGISGQAFHHGPQISNVLELDVVTGKGEVMRCSEEENTRLFHGVLGGLGQFGIITRARISLEPAPQRVRWIRVLYSSFKVFTEDQEYLISMHGQLKFDYVEGFVIVDEGLVNNWRSSFFSPRNPVKISSVSSNGSVLYCLEITKNYHDSDSEIVDQEVEILMKKLNFIPTSVFTTDLQYVDFLDRVHKAELKLRSKNLWEVPHPWLNLFVPKSRISDFDKGVFKGILGNKTSGPILIYPMNKDKWDERSSAVTPDEEVFYLVALLRSALTDGEETQKLEYLKDQNRRILEFCEQAKINVKQYLPHHATQEEWVAHFGDKWDRFRSLKAEFDPRHILATGQRIFQNPSLSLFPPSSSSSSAASW
The following text describes a protein:
Function:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid.
Sequence:
MSVGQGLCESEKVSLICGLMRQSPPGEFRQVVQDLCDLLQDDELVKQQAARAGARHNKNNFTPVLVNGNTVLLTQYNDLGGNRFFYPQDKFSFEFDHLSGVTSKTHLHRVMLDEGELWRGALHKGLNAYVNYHFPVGNCCVFKKSLGKRQMLVACIEAHQYQPSKHWNSLWKSDWTFSLTPVMTRVTGIFLLQLHYFRNANLHVTISKSVSESLHVIDRNQFVTDFVKFVKTEDNKIHNAILENIQALSEHTWRKNLRRRLPITRTFMNWNELLNNQHLKTGVSRKEVPP
The following text describes a protein:
Function:
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Sequence:
MSAKINAKKLEMFDLLKQFIDSKQNLFFLDYRGLNVAQLTELRNKIEGEHGSLKVVKNNIMKMVLKEKNINVVDSCLVGPTVVVTALEEANVIAKIFYDFVKSSTLKVKGGFVLGEFYDEAKVQAYSKLPTKKESISLFASVLKAPVSKLARTLKALADVKN
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MAQEESSAAFATLAEELEIQEALMASTITSQMAKSASPSSPPSRSSCEICRERRENDQMFKIESCIHSFCSDCINKHVATKIQGGIITPVTCPGPDCKSVLKFDACKSVLSKNVLELWEKALSQELIDASQGIYCPFKDCSAKLVYENDGEDVLSESECPYCHRLFCAHCYVPWHPGREELMMRELVKKKQLRKCPNCKYHIERTGGCLHMTCL
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).
Domain:
The F-box domain contains an unusual insert of 18 residues (131-148).
Sequence:
MANKSRPKKIKAPYRKYVAGEGFSSTRNDNKAKEFTITIPEDAELIETPQGSYYYDETNDTIVKLTRLSNEKKDKKGRKQSPSSSSTSSSKGEKNGKVIESEEARMHSVSVKMVLPWEIQHRIIHYLDIPEKEEKLNKTANGKKTTTGINMNYLLVCRNWYAMCLPKLYYAPALTSKNFNGFVDTIIINKKKNLGHYVFELNLSTILQSGRNSFVSKLLRRCCSNLTKFIAPQTSFGYAPLISLKSCHDLKFLDLGLVSETVKLKELFSAIKNFTKLTHLSFPRSSIDCQGFQDIQWPQNLRYLKLSGGITNEFVIDTKWPTTITTLEFSYCPQITELSIYSLLSQIGDNLKHLFFHYPMPSLAENSLDHVFTYCANLISLQLMVDYCSKWCFSEFMLSKLVEYDRPLKTLYLECSGSLGLASKIHPDDLTIAILESRLPCLKNICVSPKLGWNMKSDEVADLVVSLEDQDGSLYLNY