lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Domain:
The WH2 motif at the C-terminus binds to actin monomers.
Sequence:
MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLSSESHVGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSMPSSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADLSPRDTPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS
The following text describes a protein:
Function:
Involved in both the arginine and lysine biosynthetic pathways.
Miscellaneous:
MISCELLANEOUS: The reaction catalyzed by ACOAT is highly reversible. This enzyme may also transaminate ornithine.
Subcellular Localization:
Cytoplasm.
Sequence:
MAIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNVFTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFAYMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVDHLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGRARDFLYAGAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAVAKVVGA
The following text describes a protein:
Function:
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Sequence:
MFQLKCEAKCYDWGRVGRNSLAANFAEAGSDLIVENDKPYAELWMGSHTSGPSFCKQSGKPLSEILDEKTMGPRIFEVYGKTLPFLFKVLSIEKVLSIQAHPDKQLGKKLHALAPEHYKDDNHKPEMAIALTDFSALCGFRPVEQLIEFLNNIPALNEFVGQEAVDEFFKSYKQDQRAALKNLFNVVMRQSNDRIAQYTDKLVAAAEQNPVDFGGKKFGGNSLANLIVRLNKQFPHDIGLFVTLFLNYVSLRPGQAVFLRALDPHAYVSGNIIECMAASDNVIRVGFTPKYKDVNTLVENLTYQTANAEEQLTIPVPFAGANGEGKTLLYDPPIEEFSILQTVVPNGKKQSVSSIKGPSIVLTTEGNGSIVGKDGSEISLSPGTVVFVSADYDITFTASSDLTVYQAFCSI
The following text describes a protein:
Function:
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MSSSSAKVFLTRFFFGDGVSGAYFDRVVNAANMVLSSVLIWTIFTLVFNNNMPLVVVLSNSMEPDFIRGDLLLAVSPPPGSMFPNGEICAYNIRTSPVPIVHRMIETHKYGQHKLILTKGDNNPTPDNFLYQRGEEFYYNDNVETQLVAVLPKLGWVSIVVKEKKSVAVVFIIILFWNSFRDPDS
The following text describes a protein:
Function:
Catalyses the transfer of galactose onto proteins or lipids.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MVSDEIQLQNLLLSSSQSVTDHARQKIHPITQQILESGSHICPLISGTLVGPLKVNEDLTTLDEDLKILESEFKARTSVHSNLAHRVKKSLEEKDEKLITVNTIEELQKAQVNYTNAYFPLSNVEPPVGVVTPGNCYPHRRTAIVIPYRNRSEHLKVFLRHLHPILLRQDIEYGIYVINQVGNGKFNRAKLLNVGFSEALQHYNKYDCVIFHDVDLLPEDDRNIYTCSSQPKHMSIAVNIFDYKLPYNDIFGGVTALTPAQFQLVNGYSNEYWGWGGEDDDMYKRIRYNCMSILRISEEHARYLMVRHHKDKGNEIMPERFTLLKASLNRQPYDGLKSLNYTVHNRMFGVLYNNISVSIGEPLVKTMTQEEQAVHFGIGIVGIFIIYILLFKRTCS
The following text describes a protein:
Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular Localization:
Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasm. Note=Localized in perinuclear granular structures.
Sequence:
MSGSFYFVMVGHHDNPVFELEFLPPGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDVRQEDGIKNFFNDVYDLYVKFAMNPFYEVNAPIRSTAFERKVQFLGKKHLLS
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MSTNGDEEETGPSTDSADPQERVEARRLRIARRVEARKRQEMGVDPDAKKDVKEELSKSRKQIEESRQRLTKLKTDGTELVTNVEVAGDSRESQRRLEEEELRRQRTERLEAEAKASAEKFEDVTKKWDSARRYQIPQDLHELLMQQRAACDQMIDEKNKLVNDLQQELKTKDDQYVKDLKKQAEDVDLMIERMEEQIKNLTKSYREELTQIDKAFEAERGELLEGNRKKWNQTMQTRTEKEVEYLKLREKRVEEYEQQLQHLRVQDAEEYNMVKIKLETDVQILEQQLQQMRATYQLNQEKLEYNFQVLKKRDEENTITKSQQKRKITRLQDVLNNLKVKLAKQEKQYKEENQGLTDDYKRITEQYQELQKKFKHFQSTDSRKFREIWMMNEAEAKDLVHRVLEADRIIHEQQLGLPFYQPDLWFMENEGPIVPRQMQGAKLSAMEVVQKVMSDQGVGPGGAVIDEEEEIQEEGETMSMAGSQGSLASDKEQAEPQETTVMAKLTPGTIKQILELLCDESGFLVESKLNKLLAPLERDERSLMKLDAIFGALAIETEDDVHLLAQYFVKPKAAPVPQDAESAGPTPAPTERTDQPTSEAGEEGEEGSFIGSEEEELQFMMEEKESVKTTKSEVPELIHPNDIFKALRTFVNEHRQQQKKERRASSMKFVLGEERDDSQDEGYWRAMGGIIPEKKERLWSALLEGFDKYSRTLDERAKLITDTDALRQQNAELRMLLHQYVNSKVNGELEIPPTKVLQLEFSENQQQTA
The following text describes a protein:
Function:
Involved in pre-mRNA splicing (By similarity). Binds RNA (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The C-terminal RRM domain and the zinc finger motif are necessary for RNA-binding.
Sequence:
MDRYGHNVRSDIKKQGYEDSNLPILCETCLGENPYVRIIREENGKECKICKNVFTHFRWKPGENSRYKQTVICMKCAKVKNVCQTCLFDLQYNLPVQVRDKFLENSIVLPENETNRNFFLEQMENDMSSTYDKMNRINMDLSKLKRRDPYFKRNMARVCSFWRKNSCNRGDECPYLHKEIHLDKSLSNQNIKNRYTGENDILAEKILLKHNEKNNDDKNMSNKICIQGISESVSQANIKECFKKFGDIKSIKVIPKDSKMFISYSNSQAAKKASDKYKDGLLLNGCNLTVHLQDNPTYNNKNQQPVINYMNNNMYQNNMSPQMMYNPMYYPYYNMNNMHPSSAPYSSMLPSEAEQRK
The following text describes a protein:
Function:
Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (By similarity). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (By similarity). May be involved in the regulation of the BMP pathway in extraembryonic development.
Subcellular Localization:
Nucleus.
Sequence:
MSLALGHGTIAGSTAAPLSEEGEVTSGLQALAVEDTGGPSVSASKAEEEGKGSQEEAGREGSRPEEALEAPSAASDERAEGEAEDWCVPCSDEEVELPANGQSWMPPPSEIQRLYELLATQGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEKPHMPTEFDFDDEPMTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQILRTGRDLFSLDSEGPSPTSPPLRSSGNSLFPRQRKY
The following text describes a protein:
Function:
Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair. Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA) (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to sites of DNA damage.
Sequence:
MANKHNLCKKRSLDLSEESTSESHAKRQCTENLFWPEGEDDDSFFSNAHLEDLLDGRKEELFGTQATTSTNKMTQSGSDDGLGLFADTSFPSAQSVPPNSASKPDEASAPTDKHQIDLADEENADKLFKKINLNDLSIAEMEDIFHGADDFSDPMVQNTQLFLDAMTFKKPKTPEKLLAPLKDDSMSFISKSVIEGLVQGTQYVTCEELKNQSLLDPVNWETQAFADFEKNNQDIDKFPSKGEFYGLPDKVKKMILEHKGINSLYEWQDECLNLPAIRQRKNLIYALPTSGGKTLVAEILMLRELLCRERNVLFILPYVSIVQEKVSAMSPFAIDLDFIVEEYTAGKGKCPPQPRRKRRSLFIASIEKGAVLMDSLIDVQRPHEIGLVVVDELHLIGEKGRGATLEAFLTKVMFLNANIQIVGMSATIGNLSEISSFLNADVYTRGFRPVELKEYIKCGPDLLEINSAGQTLEEIFVPSRSVEYNYSEAVKRADPDHLAGLISECAPEHCCLVFCPSRKNCENVALLLSRIVPKHKFFEHRRSEKLDLMDALDKMCGILSPVLAKTLPYGIAYHHSGLTTDERKYIETAYRFGVVTVICCTSTLAAGVNLPAKRVIIRAPYVGQEFLTLCKYKQMVGRAGRAGLGEAGESILIAQSKDNLLVGQMLFSPMDKALSSLDQNEAVGLQSLILSVVGLNLAECRRDLNRLVNSTLLSVQAKSLEVAVNEIVLRILREMFKNKVLQLAEPQAKSKINSSDIITSQDVSQANRPAGDRRLLIGQSTPFKLTNIGRAAFKAGIDYKRANAIHKELKQAQQQLILTNYLHLLYLVVCFNSNERGDELFPADASILFGVYTSLPLDSQAMFKQLGFTEAHAARLFKTQSVQGPLSLQLNRLYKVLILADILNLLPIPSVASKYNVERGTLQHLISQSTAAASAIVRLCEELEEFWCYKPLFERILHKMDRCGTFELEPLMELPAVKINRARQLYAAGFQTIGDIARVRPSHLVQSLEHMPLRVATEIVSAAKIILMKKLDHLEEETENLKDCLKTSDKN
The following text describes a protein:
Function:
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (By similarity). The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development.
Subcellular Localization:
Cell membrane. Note=Colocalizes with APP in lipid rafts.
Sequence:
MAQPGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKSPENLLDNDPSFFCRFTVVVATQLPESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPDNEIVLYLMLRAVDRFHKQHGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
The following text describes a protein:
Function:
Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell. In addition, plays a role in the inhibiton of host BECN1-mediated starvation-induced autophagy without affecting basal levels of autophagy.
Miscellaneous:
MISCELLANEOUS: EA-R is part of the restricted EA-complex.
Subcellular Localization:
Host membrane; Single-pass membrane protein. Host mitochondrion. Note=also observed in the perinuclear region of the cell.
Sequence:
MAYSTREILLALCIRDSRVHGNGTLHPVLELAARETPLRLSPEDTVVLRYHVLLEEIIERNSETFTETWNRFITHTEHVDLDFNSVFLEIFHRGDPSLGRALAWMAWCMHACRTLCCNQSTPYYVVDLSVRGMLEASEGLDGWIHQQGGWSTLIEDNIPGSRRFSWTLFLAGLTLSLLVICSYLFISRGRH
The following text describes a protein:
Function:
Sterol O-acyltransferase that catalyzes the formation of stery esters.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTSIEDQVVESADSKILVKKSVVTTEPELVVQADGSSKYIRRIITTTTTTTAKNKATELNASTTTASSSEVSALTSTLESKSENVTSNVTETEAEMLKVSASSESQAMDIKKAFIAESSSVGDEKNVSQSVNTVKHIVQDTKETMAAECSSSTDKKELSVKKSTMEVATEIYQKLATFIYSLTDKSSSSSVVKPPPVPLKKSTLLDVDRLELINSNLVGIYIIAQVCLVTFMICSCHAHYMRVGTLFDPVVYNIVFINIQSLFLAEFRLLLSTLPTLFIQQALASEFIPESASCAVLGVWESTWLVYWVALVSTSHFAWPQRVVLAVHVIILLMKQHSFMVTNNKIRQSHLKDGSPPSYESTAKVLDSDVAQTAASTSTNAEKDDRMFFLRNFTILHYGYWLAVPSLVYQTSFPQMPAFRPIHFAYYTAWTLISALGLYITLDHLIYPVMRDISINGFYHTFVYLIPGTIMYVFLVFLTVFEYALNAMAELTLLDERDFYDDWWNSLGYESFSRKWSTVVYRFLHKHVFLELKEYFNLSRPAAMFFTFTVSATLNELILFMVTGTFRTDYFRMITLQSLYIWTDYVMPPAKKSFGITGFWGGYFFGPPFIIIAYSRYFFEQN
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
Sequence:
MIITEDSMPATATADDPILKVWTSFKSTTKDAPDYEPLRNQLVERYMQLVRYNGERIWQRLPDGVELDDLISAGMFGLMDAIDAYDTERGVKFETFCVPRIRGAMLDELRKMDWVPRLVRSKASKLATATKTLEARFGRAPTVQELSAHMEIDVKEVEKMQSEANAVGVVSLNKKWYETDSYKDVREIDILEDKKGEDPTRRVQKNDLMRLVTKGLNRNERLIIILYYYEELTMKEIGATLDLSESRVSQMHTAIVNRLQQQLGVRRLEFGA
The following text describes a protein:
Function:
Degradation of the cholesterol side chain involves 3 multistep beta-oxidation cycles, this is involved in the second cycle. Hydrates bulky steroid enoyl-CoA esters, has highest activity with 3-OCDO-CoA (3-oxochol-4,22-dien-24-oyl-CoA) making (22S)-HOCO-CoA, followed by octenoyl-CoA, with weaker activity on 3-OCDS-CoA (3-oxocholest-4,24-dien-26-oyl-CoA) and none on 3-OPDC-CoA (3-oxo-pregna-4,17-diene-20- carboxyl-CoA). Hydrates the same substrate as EchA19, but the 2 enzymes make different stereoisomers of the product.
Sequence:
MPIDLDVALGAQLPPVEFSWTSTDVQLYQLGLGAGSDPMNPRELSYLADDTPQVLPTFGNVAATFHLTTPPTVQFPGIDIELSKVLHASERVEVPAPLPPSGSARAVTRFTDIWDKGKAAVICSETTATTPDGLLLWTQKRSIYARGEGGFGGKRGPSGSDVAPERAPDLQVAMPILPQQALLYRLCGDRNPLHSDPEFAAAAGFPRPILHGLCTYGMTCKAIVDALLDSDATAVAGYGARFAGVAYPGETLTVNVWKDGRRLVASVVAPTRDNAVVLSGVELVPA
The following text describes a protein:
Function:
May hydrolyze 6-phospho-mannosyl-D-glycerate to mannose-6-phosphate and glycerate.
Sequence:
MKAVSRVHITPHMHWDREWYFTTEESRILLVNNMEEILCRLEQDNEYKYYVLDGQTAILEDYFAVKPENKDRVKKQVEAGKLIIGPWYTQTDTTIVSAESIVRNLMYGMRDCLAFGEPMKIGYLPDSFGMSGQLPHIYNGFGITRTMFWRGCSERHGTDKTEFLWQSSDGSEVTAQVLPLGYAIGKYLPADENGLRKRLDSYFDVLEKASVTKEILLPNGHDQMPLQQNIFEVMDKLREIYPQRKFVMSRFEEVFEKIEAQRDNLATLKGEFIDGKYMRVHRTIGSTRMDIKIAHARIENKIVNLLEPLATLAWTLGFEYHHGLLEKMWKEILKNHAHDSIGCCCSDKVHREIVARFELAEDMADNLIRFYMRKIADNMPQSDADKLVLFNLMPWPREEVINTTVRLRASQFNLRDDRGQPVPYFIRHAREIDPGLIDRQIVHYGNYDPFMEFDIQINQIVPSMGYRTLYIEANQPGNVIAAKSDAEGILENAFWQIALNEDGSLQLVDKDSGVRYDRVLQIEESSDDGDEYDYSPAKEEWVITAANAKPQCDIIHEAWQSRAVIRYDMAVPLNLSERSARQSTGRVGVVLVVTLSHNSRRIDVDINLDNQADDHRLRVLVPTPFNTDSVLADTQFGSLTRPVNDSAMNNWQQEGWKEAPVPVWNMLNYVALQEGRNGMAVFSEGLREFEVIGEEKKTFAITLLRGVGLLGKEDLLLRPGRPSGIKMPVPDSQLRGLLSCRLSLLSYTGTPTAAGVAQQARAWLTPVQCYNKIPWDVMKLNKAGFNVPESYSLLKMPPVGCLISALKKAEDRQEVILRLFNPAESATCDATVAFSREVISCSETMMDEHITTEENQGSNLSGPFLPGQSRTFSYRLA
The following text describes a protein:
Function:
Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man). Catalyzes epimerization but also isomerization for beta-1,4- and alpha-1,4-gluco-oligosaccharides. Can use cellobiose, lactose, cellotriose, maltose and maltotriose.
Sequence:
MDLKVLKSEIFEHLNNKIIPFWEELKDENNGGYISYVGFDLKPDPYAPKGLVLTSRILWFFSRLYNQLRKEEFINFADHSYKFLIKSFLDKENKGFYWMVDYKGEPIDKRKHLYGQAFVLYGLSEYYKATQKKESLDLALEIYKIIEEVCKNDVGYKEEFDEKWNPKENIIVSEYGIICERSMNTLLHILEAYTNLFTATYDQSIKKKIEDLIILFKEKIYDSKTNHLYVFFDKKMNPIIDAISYGHDIEATWLIDEALRYIDNNKLIKEMSEINLKIAEKVLEEAFESGSLLNERVRGIVDKNRIWWVQAEALVGFLNAYQKSKLDKFLKAVFELWEFIKDFLVDKRAQGEWFWKLDENYIPSPMPEVDLWKCPYHNGRMCLEVIKRI
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLAQNSREVLDKDLESHIPGAYSPAPPSSSLPTQNESNLQQSEKPLKHFENKKFKGEDVFAHSISKPFDGQNDEEKPSLYSHLTNELYETHDSSDYFGTYMEREESGHDEEEADKDASFTGYYNSRNNDEEGSELADSQMLPMTESFADIEDIHHHQHEDEFSSSNKDKGFTYEKPVTELPPKRPPYHYESSSTSISFVNGGPNFRKVKSGLLKPDADAASNLSTTSLVNQEYVMKQVTPNEYSMEYLRESFPQTPMGTEASGYSFDRTPHKSDIQASDRLNALNEKLLQGIQQSHQPYHYTNVKDSQGSHQTKVTIEENMEAPSHQAANRTTLTDSPLGIVEDETTILTDLEPSGPGLQKRASETSMSTNVSLPYYQNGRRVRNILTPYPTVSLASTMTSETEDVSEERI
The following text describes a protein:
Function:
Involved in the biosynthesis of the nonproteinogenic amino acid monomer (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of balhimycin antibiotic. Catalyzes the Claisen condensation of four molecules of malonyl-CoA to yield 3,5-dihydroxyphenylacetyl-CoA (DPA-CoA) and three free coenzyme A (CoA). DpgA requires the presence of the dehydratases DpgB and DpgD to facilitate the aromatization of the DPA-S-DgpA or DPA-S-CoA intermediate.
Sequence:
MGVDVSMTTSIEPAEDLSVLSGLTEITRFAGVGTAVSASSYSQSEVLDILDVEDPKIRSVFLNSAIDRRFLTLPPESPGGGRVSEPQGDLLDKHKELAVDMGCRALEACLKSAGATLSDLRHLCCVTSTGFLTPGLSALIIRELGIDPHCSRSDIVGMGCNAGLNALNVVAGWSAAHPGELGVVLCSEACSAAYALDGTMRTAVVNSLFGDGSAALAVISGDGRVPGPRVLKFASYIITDALDAMRYDWDRDQDRFSFFLDPQIPYVVGAHAEIVADRLLSGTGLRRSDIGHWLVHSGGKKVIDSVVVNLGLSRHDVRHTTGVLRDYGNLSSGSFLFSYERLAEEGVTRPGDYGVLMTMGPGSTIEMALIQW
The following text describes a protein:
Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex. Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking.
Subcellular Localization:
Cytoplasm, perinuclear region. Lysosome membrane.
Sequence:
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGEGLLTPDTQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTAASDVAAIPADTPLNEDNEGFVKVAETPDKSEISKHIEVQVAQETRNVSIGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLDFYLLSLVGMGREVENLILENTQLLETKNALNVVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNKELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDASMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLESEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVIIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEELSESGQVDKASLCGSMTSNSSTETDSLLGGITVVGCSTEGVTAVATSPSTNGTSPVTEKPPEKEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQAGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETVILHQGRLLGLRANKTSGASGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSGSSGTDLTADKVGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGSE
The following text describes a protein:
Function:
Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6).
Subcellular Localization:
Membrane; Multi-pass membrane protein. Perikaryon. Cytoplasm, cell cortex. Early endosome. Late endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasmic vesicle. Note=Integral membrane protein not detected at the cell membrane. Detected in cytoplasmic vesicles in the cell cortex, close to the anterior pole of migrating neurons. Detected at the base of the leading process in migrating neurons.
Domain:
The C-terminal region after the fibronectin type-III domain presents structural similarity to annexin domains and binds calcium ions.
Sequence:
MAAAGARLSPGPGSGLRGRPRLCFHPGPPPLLPLLLLFLLLLPPPPLLAGATAAASREPDSPCRLKTVTVSTLPALRESDIGWSGARAGAGAGTGAGAAAAAASPGSPGSAGTAAESRLLLFVRNELPGRIAVQDDLDNTELPFFTLEMSGTAADISLVHWRQQWLENGTLYFHVSMSSSGQLAQATAPTLQEPSEIVEEQMHILHISVMGGLIALLLLLLVFTVALYAQRRWQKRRRIPQKSASTEATHEIHYIPSVLLGPQARESFRSSRLQTHNSVIGVPIRETPILDDYDCEEDEEPPRRANHVSREDEFGSQVTHTLDSLGHPGEEKVDFEKKAAAEATQETVESLMQKFKESFRANTPIEIGQLQPPLRSTSAGKRKRRSKSRGGISFGRAKGTSGSEADDETQLTFYTEQYRSRRRSKGLLKSPVNKTALTLIAVSSCILAMVCGSQMSCPLTVKVTLHVPEHFIADGSSFVVSEGSYLDISDWLNPAKLSLYYQINATSPWVRDLCGQRTTDACEQLCDPETGECSCHEGYAPDPVHRHLCVRSDWGQSEGPWPYTTLERGYDLVTGEQAPEKILRSTFSLGQGLWLPVSKSFVVPPVELSINPLASCKTDVLVTEDPADVREEAMLSTYFETINDLLSSFGPVRDCSRNNGGCTRNFKCVSDRQVDSSGCVCPEELKPMKDGSGCYDHSKGIDCSDGFNGGCEQLCLQQTLPLPYDATSSTIFMFCGCVEEYKLAPDGKSCLMLSDVCEGPKCLKPDSKFNDTLFGEMLHGYNNRTQHVNQGQVFQMTFRENNFIKDFPQLADGLLVIPLPVEEQCRGVLSEPLPDLQLLTGDIRYDEAMGYPMVQQWRVRSNLYRVKLSTITLAAGFTNVLKILTKESSREELLSFIQHYGSHYIAEALYGSELTCIIHFPSKKVQQQLWLQYQKETTELGSKKELKSMPFITYLSGLLTAQMLSDDQLISGVEIRCEEKGRCPSTCHLCRRPGKEQLSPTPVLLEINRVVPLYTLIQDNGTKEAFKSALMSSYWCSGKGDVIDDWCRCDLSAFDANGLPNCSPLLQPVLRLSPTVEPSSTVVSLEWVDVQPAIGTKVSDYILQHKKVDEYTDTDLYTGEFLSFADDLLSGLGTSCVAAGRSHGEVPEVSIYSVIFKCLEPDGLYKFTLYAVDTRGRHSELSTVTLRTACPLVDDNKAEEIADKIYNLYNGYTSGKEQQMAYNTLMEVSASMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKAHLILRRLERVSSHCSSLLRSAYIQSRVETVPYLFCRSEEVRPAGMVWYSILKDTKITCEEKMVSMARNTYGESKGR
The following text describes a protein:
Function:
Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.
Subcellular Localization:
Nucleus.
Sequence:
MGKRKSSSRKPAKKIKQTLDTTFTCLFCNHEKSVICTIDKKNLLGELHCKICGQSFQTAIHSLSQPVDIYSDWIDACEDLAEEAEKHGNDEEGDVYSDGDDNTATNNNSGRHEKDPILDSEDEDDENF
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MMSPTIPARIERPSTRHFKHHRMIIVKNLYNDGWLNSHFHEILQLQDADNPAFVREILSLYVSDSRRLINLMNRPLGMDTVNYKEISVHVRGLLGSSLDIGAEGISKACLRLFNGTKAENKEETVLALKQLTSEFNKMKPKLEHLVQMERLILQSVLYRGWNDGHESSQIGCETKRSREA
The following text describes a protein:
Function:
Receptor for basic fibroblast growth factor.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
EIPRDDVDFGKELGSGAFGEVYAGTVSKDGKCLPCAVKTLKRHATEREYRDLFNELSIMGQVGFHPNVVNLIGACTVDGPLWVIVSLAENGNLLDYLHLHRKPNYQYHSYENIPTVSTEQPEEISYVQKLKFAHGIAQGMRHLEKHKCVHRDLAARNVLLGRGLEPIVSDFGLSRDIYESGMYEDLRGGKRPVRWMAPESIEDYTCTSKSDVWSYGVLLWEIETQG
The following text describes a protein:
Function:
Plays an important role in regulating embryonic neurogenesis.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MDPSEKKISVWICQEEKLVSGLSRRTTCSDVVRVLLEDGCRRRCRQRRGQRRGLTEDPSGQLELPEPPDENDEDDDDAMPPGMLCGPPQCYCIVEKWRGFERILPNKTRILRLWTAWGDEQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCLARGAPARPSLALTQEKQRRVVRKAFRKLAKLNRRRQQQPSSPCSSTSSSTASSCSSSARTHESASVERMETLVHLVLSQDHTIRQQVQRLRELDREIDRYEAKVHLDRMRRHGVNYVQDTYLVGAGIDLDGQTPEGEPEDATLEEKGTEPAAPLDSEAQAAALEELARRCDDLVRLQEERAQQEELLERLSAEIQEELNQRWMQRRNEELAAREESLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLSTDLEAVKADLDYSQQQRDIKERELQGLLQSLHTFEQTVVHDGALGSSGPSREPQPQTCAEMWVDQARGLAKSCPGNDEDSDTGLSSMHSQDSDSVPPVCESLV
The following text describes a protein:
Function:
May act as a component of the auxin efflux carrier.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MISLHDLYTVLSAVVPLYVAMILAYGSVRWWGILTPEQCGGINRFVAIFAVPLLSFEIVSSNNPYAMNLKFIAADIVQKLAILAALALWVKLSRHGSLEWLITLFMLATLPNTLVMGIPLLAAMYGAKPGGLIVQAVVLQCVIWYTFLLFLYEYRSAKLLIQEQFPDTAGSIISFKIESDVVSLDGREPLQTDAEVGDDGKIHVTVRKSVSSHHSMLSPRRSVGLRSMPSSKALTPRPSNLTGAEIYSMHSSRNLTPRESSFNRNDFYSLMSFTNIPPPRQSNFTNTDVYSLHSSRGPTPRTSNFNEENSRALNNAAAASPSPRFPLYNSSSSIFPKPGDGGFGFSPKHHHGGELRASPKLVHNNRSAVAAEDPNAKDLHMFVWSSSASPVSEAHPQHQQQQHGGVLGGYGGTSDYTATTTTNNNINGGDLKERLSPLAHQSVPGRQYDEYDRDDFSFGNRPSFRGDESMIADKEGPSLTKIGSSSTAELAPKDGDNKAEMPPARIMTRVILSMVWRKLVRNPNTYSSLIGVIWALISFKWHIEMPVIVDKSITILSRAGLGMAMFSLAGLFMALQKRLLACGTSLAIYGMVVRFLTGPAVMAAASIACGLRSVELKVSIVQAALPQGIVPFVFAKEYNVHPDILSTAVIFGMLVSFPITLLYYVLLGL