lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Subcellular Localization:
Cytoplasm.
Sequence:
MQTLLALNWKMNKTPTEARSWAEELTTKYAPAEGVDLAVLAPALDLSALAANLPAGIAFGGQDVSAHESGAYTGEISAAMLKDAGASCVVVGHSERREYHDESDAXVAAKARQAQANGLLPIVCVGENLDVRERGEHVPQTLAQLRGSLEGVGADVVVAYEPVWAIGTGKTATADDAEELAAAIRGALREQYGARAEGIRVLYGGSVKPENIAEICGKPNVNGALVGGASLKVPDVLGMLDALR
The following text describes a protein:
Function:
Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit.
Subcellular Localization:
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MVQKSSMSRTPSTSTQEIQMDMFDHHPHTQGKYAKRKSRFKRSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDPEALRKEADRQALATLEKAKTKPVAFAVRTNVGYNPGPNDDVPVQGMAISFEAKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLENTRLLQEQRMRQNRLSSSKSGGSSSLDVATGTRRPTPPGTGGPAKQKQKSMEHVPPYDVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHKFEGRISITRVTADISLAKRSVLNNPSKHTIIERSSTRSSLAEVQSEIERIFELARTLQLVALDADTINHPTQLAKTSLAPIIVYIKIASPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDIILDENQLEDACEHLADYLEAYWKATHPPSSNPPNPLLNRTMATAALAASPEPVSNLQGQYLVHGEHKREGVLTESGGSSTLRDYKSDLGGKPQQHHQQQACLRSSRGQLRGGSSRGLSRQDTFDSETQGSRDSAYTEAGDSCMDIETDPYEEPEPYRSGGGSRLHLAQHHGRQASWEDEGAEPDQENLNHPPMPSQTQPHGRAKLKERYCQDPVDTGANISRNKNQDDWGRDVYIR
The following text describes a protein:
Function:
Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity).
Subcellular Localization:
Apical cell membrane; Lipid-anchor, GPI-anchor. Note=Localized at the apical membrane of the most differentiated keratinocytes of the outer root sheath (ORS), clustered mainly in planar regions of the plasma membrane at the base of microvilli.
Sequence:
MAVLRSLLPQLGLFLCLALCFSPALSASYNDPCTVFDTISTTNLRVNITAEGSGENITYTVWVHVNSSVSVVILKAVNQDNKPVGTWVGATQECNDSSVLYRVTPSDNSDFQATWIVPNSEDITKVNLHVLMAIGNGTAAVTSVNLGEPQTSTPLRPTPEISETNQTTTMTTDKTPAMTTAKTPAMTTAKTTAKTTAKTTVKTTAMTTAKTTAKSLAVNALGSPLAGALHILLVFLISKLLF
The following text describes a protein:
Function:
Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.
Subcellular Localization:
Mitochondrion.
Sequence:
MSLLEDVVYVLRTVLEYFGVPPDMLDPVWTSQLCGQYRSIIRMIGTNLPLKPPPRVHFQIPLVANMLHDVDATGDTPAIPSLADIMWVFEDKGDSFAKTRMHLPPKKQNCINAIQNDLEPNIVHKKERSAGHAADPETLKKISALESELLKLRAQIAMIVTATPGADQTESHNAPLVSLTSPLPLPALTSTPRSAPAPPPPPPPPPPCPSSSTDTLDVMQLIRQNRKNKTVNGQLQPHNKESENKGMPSMMDVLKNLNQVKLRSVQRSPGGTPVGGRRSKGGAAVLSDPAALIAEALKRKFAQHRHNTSSDKENSRELSPFGSPESPKVSVHFRRSQGRRHF
The following text describes a protein:
Function:
Nucleotide-binding protein.
Sequence:
MPSFDIQSELNKHEVSNAVDQANREVATRFDFKGSGATYKYEGNSITLQAETDFQLKQMIDILQNKFAKRQIDVAHMKLEDPIIQHKSAQQTVMLLEGIDQTAAKKIIKLIKDQKLKVQAAIQGEKVRVTGKKRDDLQSVIGLLKEQEIGLPLQFDNFRD
The following text describes a protein:
Function:
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal zinc finger binds to poly(A) RNA; Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs; The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.
Sequence:
MQVCVNFIQRRATELQPKVILINRLSAHLSTSPSPPLPHPLVTTSHTPVGALTPKPPNTSFGSHHQVSIAMPKFNINSPSFTPSVVDKAAIDSTGPAAPAAAPAFVPGKSPIDLEQIKNKLTISKDKKENAKSALPKLNPAVAGFTPGASASGSTTPKMATAPSFQPNQTSAINTNSNSSASATSQSGPPGASFQPNQSFQPGAASFQPRFQSGPSQIEPGYDNYYDEMSNGAVMAAAQNQQFPLQYHLYAPHYLSASRQRQLLSHQKTAKDFFLDPHLHQRLHKQSEDLLRVEGSSNLPRFVDKYHSLVLLDSNLNTKENGAPGESPQWVYKCMNGKDGKQYALRRIQGFVLTNEQAMTSVRKWQSIVHPAFVSLCEAFTTRDFGDASLCMIYDFLPSAETLFDLLNRGQQFSRDVIISYLLQLLSVLDTIHSAGLAAKTVDPTKILVCGPGRVRLNCCGLYDVINFDKDENVTLFQQQDLRNLGLLVLCLACNSVEATKNVEQSLTRLDSELQEIVQYLLSSNTSKTASRVLASLTPLLTATFNESLNTNDSLEHELRRELENGRLVRLMAKLNFITERPGPDPEMSQQWSETGDRYLIKLFRDYVFHQQDEMGKPVMDLGHVVRTLNKLDAGIDERITLISRNGQNCLIVSFKDLKQCIESALRDLE
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLVRLELRNEYGLGDPELYRGGFRKEEPKAILDGVAVSGLVGILRQLGDLAEFAADVFHDLHEQITATAVRGRQMMTRVQNIESTVPSIEKAFGKQTSYVHFAYVAGSDWHARIRDEQSIVLSTELPRFMMDSYEECRDPPRLFLLDKFDHAGTGACLKRYSDPPYFKRVWTASQMENSENFQKEKKVHKTKRKGSRPRHGEVKHAVYISHHDSSGIRFASPSIDGQRFSAVNVSSPDMRLNLEFLSRSTSFASKTRENYAEQTSYVNPQGVPDDLDYSEVPNPNLHSKDSHLSVPVLHDEPSADGLYNVAQHDLPQEQSVPRSSSVTWDEKLEIVKPTSPVSYNDILVDRVQDLENVISVQDSEPLQVNFKTENVEHAKIEALNQEDILCHIGKTSVPVSGVSHFDEVSSETDNYVDAPNTLDSESETEAGCHTKSEVQILSNFSSQGMEPRTEMRQVIAVQSSEPSDVEAHNSSHSSLSQDVTPRFLHLSSLNGSEHVQSPYATEFLQKQEQTVVDDFCERNAPNISETKFHAYECIDSVLSPISGTFSSPTMMLAETRCEGSILKPDPLADVSGVPSIKLWTNGGLFGVEPSKPPELGSVNTQSKNFISDSRNFASDFSSRTLKSQTLVNESDAPCMQNEPTSVDANSQGKVAGEPTNLDSSVQSNSTEDQFFARGYNTVQKFKGSPSCHDNQHVYNVKQDSNVSAEPFLQRKFEHNSEDTDVSNYASSDKLDMTRNSASSGAPLTDIYCTGSRQNGPSQSTVGISSSFSELAQRFLANTIHREASLSTPSGNINTEIRKPKGATSCLHDDIEVSNEVASQRTDEQSTNKKVAHVPAKEPVSFTSYYHEQSSPPLEYMKISSHPMNGLDNSKLKLDFSGGNLHENSEDATFPSFQLHHGPVDNLPVVLSESDDDTFHRSCPYSSEELLSPRSYTSSEQWEQEGRSEYVDHELNDVPYRFQSSTTSISRSMGFEQMNHSSISKPDGLEKFDAIIDSSKVPSQSVSAMELPGLDSVLSVKNQQERKFPSLRENPANVEVQSTNELPPPPPLPPMQWRTFKLSIKLDDNDPNISSNLNHLDELQPLRCPSQIKEQYLPGSPFVNEPISPHSDKIQDQLKLNWEKRSTRSVSHKEVDRREDLLDQIRNKSFNLRRAKISMPRDIPRPKTSITNANVAAILEKASAIRQAFVGSDKGGDDDNWTDA
The following text describes a protein:
Function:
Promotes the exchange of Ras-bound GDP by GTP.
Sequence:
MNDSTQILDESGDFSFLSLNENKSRSRSTSTCSINSVEIIDGGSCDSSGDDDKNNSYLDEEKKRILRKTYLYFNANNKKTQLNFIIDNQVLDWIFNQTKTKISKPICESLKNGVALCKIINLIKPNTIKKINLNSSIFSYRENLTNFTKGCESIGMTEDMSRFQELVFEDKESAVLQLLYSLMKFSEKILPNTISTSPPSQLNICKSPVLLKKAAAQSSSSSPTTSTSASTSTSTSPSSSNESIAKPILSALSSSSSTLFSAAPTPTSTNTVPYKFIGHSKSKLFGQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPPPQTSTCTTTQPTTTTTEEHKLAPPPPLIVPNTSSLPPPQPTTSSIIKKAAPAPLKKPSPANTSSNSLLNHLPPPPSSSSTASSAINTPISTPSTSKSNSFQKPNNNFQKPIQIAHVEPIIEENEIEDNTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNDNINNNNKNNNNNQNENEDEVKPVHSPPKVRPPLPSRVGRGQLLRSSSEEIQFDIENASVSEAPSPVMTMNEDYSIVTDANSLTNHYNGANEYTTTTTAATTNLPNESSSRSNSASSNGDQNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNLQLPAKINSEPNNQYNTISTSSPSTTGTILESPNGSSIFSQPLNNNNNINNENNNSNNSNSLVTSSSPPLSLPAYSANGSPNCPQGKKQRSGTKLRSFFGVKSKPESKSVSNFYGVGNSINQPPSNSSPKQSPVPNNPPSVSQSFLNLSMNSKSSKKKKDNISPDINSNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNLEEDENPLTMSNQSANSLKSSGNHFEDDITNGNNNISQNQNQNQNQNQNQTQNQNQNQNQNHISHSNSISSGNLNNHVNQNNNVNEESVDSELMKALSKVEFLFKDRKVLKERINFTYPEKYLKFFVNMDELIQIDNSTTFLTESLLSKRPSQQLELCHQEERRFLSEIVTLQNVLNVVEENKNLITRTEEMQKMIDSLMKEKKELINEKNTLASMLAKTKQQQQQQSNDTVSQRKMVDDGIVYNYNHGKYEIKGGTTEKLIELLYNSEFIGSDYFETFLLTYRSFASPKRVMDVLTKTYNENYSVEGNATDDVEKRLELDQFNKQRKDTHLKICNFLKRWVEKHFYDFDQDLLQEFNTFIANCRVINHQDFLQKTLNKKLIPLSSSELKLVFSTPTPAPILPKTPITCFEDMDPAEIARQLTLIEFNLFKNIANKEFLSLSWQKQDKEKRSPNLLKMIYRFNEVSNWVTSTIVKETTNIKKRASYLKRFIKLAEELRKLNNFNGVFVIVSGLHSASVNRLKNTWAEISKQQQKQFEEFVALTSPQSSFASYRLELRQSTGASIPYLGVHLSDLTFVEEGNQDKLENGYTNFSKCRLIAEQIKAIQEFQQEPYNLREVEEMIPFITHKAVPESECFNLSLICEPRESVN
The following text describes a protein:
Function:
[Capsid scaffolding protein]: Acts as a scaffold protein by binding major capsid protein in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein. Cleavages products are evicted from the capsid before or during DNA packaging; [Assemblin]: Protease that plays an essential role in virion assembly within the nucleus. Catalyzes the cleavage of the assembly protein after formation of the spherical procapsid. By that cleavage, the capsid matures and gains its icosahedral shape. The cleavage sites seem to include -Ala-Ser-, -Ala-Ala-, as well as Ala-Thr bonds. Assemblin and cleavages products are evicted from the capsid before or during DNA packaging; [Assembly protein]: Plays a major role in capsid assembly. Acts as a scaffold protein by binding major capsid protein. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Cleaved by assemblin after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging.
Subcellular Localization:
[Capsid scaffolding protein]: Host cytoplasm; [Assemblin]: Host nucleus; [Assembly protein]: Host nucleus.
Domain:
Region of interaction between pPR and pAP is called Amino conserved domain (ACD). The region of interaction with major capsid protein is called carboxyl conserved domain (CCD).
Sequence:
MADPVYVGGFLVRYDEPPGEAELFLPSGVVDRWLRDCRGPLPLNVNHDESATVGYVAGLQNVRAGLFCLGRVTSPKFLDIVQKASEKSELVSRGPPSESSLRPDGVLEFLSGSYSGLSLSSRRDINAADGAAGDAETACFKHVALCSVGRRRGTLAVYGRQPDWVMERFPDLTEADREALRNQLSGSGEVAAKESAESSAAAAVDPFQSDSYGLLGNSVDALYIQERLPKLRYDKRLVGVTARESYVKASVSPAEQETCDIKVEKERPKEPEQSHVPTESMSHPMSAVATPAASTVAPSQAPLALAHDGVYLPKDAFFSLIGASRPLAEAAGARAAYPAVPPPPAYPVMNYEDPSSRHFDYSAWLRRPAYDAVPPLPPPPVMPMPYRRRDPMMEEAERAAWERGYAPSAYDHYVNNGSWSRSRSGALKRRRERDASSDEEEDMSFPGEADHGKARKRLKAHHGRDNNNSGSDAKGDRYDDIREALQELKREMLAVRQIAPAALLAPAQLATPVASPTTTTSHQAEASEPQASTAAAAPSTASSHGSKSAERGVVNASCRVAPPLEAVNPPKDMVDLNRRLFVAALNKME
The following text describes a protein:
Function:
Endoplasmic reticulum (ER)-resident protein that confers cellular protection as an anti-apoptotic protein by limiting multiple stress-inducing pathways surrounding the endoplasmic reticulum and mitochondria. Inhibits the activities of the key sensor for the endoplasmic reticulum unfolded protein response IRE1alpha/ERN1 both directly and by blocking BAX/BAK binding. Modulates ER calcium homeostasis by acting as a calcium-leak channel (By similarity). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The intra-membrane loop at the C-terminus acts as a calcium pore, mediating calcium leak from the ER into the cytosol.
Sequence:
MNIFDRKINFDALFKFSHITPSTQQHLKKVYASFALCMFVAAAGAYIHVVTHFIQAGLLSALGSLGLMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALDLCIAINPSILPTAFMGTAMIFTCFTLSALYARRRSYLFLGGILMSAMSLMLLSSLGNLFFGSVWLFQANLYMGLVVMCGFVLFDTQLIIEKAENGDKDYIWHCVDLFLDFVTLFRKLMMILAMNEKDKKKKK
The following text describes a protein:
Function:
The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDWEEVTKLEENEYKRGYDEGILKGIEQGYEEAFLFGLEHAYNKYLLAGEIYGRVCFWLKEENSQHPKIKKAHRHLEQLKSLLESLPTNNELEETDAGFDSYWNKITAKAKVVSSLLGTKILPAEKIDANDGFE
The following text describes a protein:
Function:
DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs.
Subcellular Localization:
Nucleus.
Sequence:
MSLRGFRKPAQNGNADGNEAGDGKLSLIPGRKRIQMMGDSDSESDASTTPIKPVPIPVVGAVKENGATKSPAALTIKEKELRLQMVRQACMDVDAMLLQSSLVSNEWDVDKAIEELKKTAVKRKIIVSPSPVKPATAETATNGKEKNQQQAKKRRVQEPNRSDDESDVDSDRPAEQVFDSDEDSDGHGGSYSHGKLSNERKNVLEFLNTAGLNEMICVKTLSMKKIELLLEQRPFKDWSNLVDKLKSHRSLQTDILNYTQEYLTRRKNIAAMMSKCKKITKKLEEAIASGSGTLVEQPGNIADGFKLAEYQLVGLNWLTIMYRHKMNAILADEMGLGKTIQIIAFLAWLKENNHQERPNLVVVPSSTMDNWEQELVKWCPELVILKYYGSQAERRMIRVDWAKNGINEVDVVLTTYHMMGASGEEKKMWRVTQFDYVVFDEAHMLKNVHSQRYQNLIRINAKYRILLTGTPLQNNLLELMSLLCFVMPKLIGSKVEDIKTLFQGKVKTNKGEGEEELSSFEKNQIDRAKLIMKPFVLRRLKKDVLAFLPPKKEVVLKTSMIDSQQEKYNEIVNEYQNATGKVKDYTEISGMSIMMDLRKLANHPLLLRYYYSDDDVRNIARKLATDPDYKGTKEDDIFYDIAYLSDFKLYEMRDKYTTLYDLQLPEKLITSSGKFRQLDELLPKMKEEGHRVLIFSQFTMMLDIMERYLKIRKHGFLRLDGSTAVTERQELIDQYTQDPDLFIFLLSTKAGGLGINLTAADTVIIHDIDFNPYNDKQAEDRAHRMGQKKPVTIYKLISEGTIEEGMLMIAQQKLQLEKDVTEQDGKNPMDDHKCMVGLLTMALGLDEKKAETILKNESPMKKPMQEEF
The following text describes a protein:
Function:
Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Sequence:
MMVLFLVSAALISNSSSHGNLTTESPAPQGSHVLASGLVTSLLLVIFLLLVAYILRFREQRKDLVTSVDKKLPNGFLEDQEQTVVLLPRSPSPSKRYFPIPLDSLEEEFRLRMADDGKLFREEFNSLPCGFGCGTFEEASREENREKNRYPNILPYDHSRVLLSHIDGYMGSDYINASYIDGYREKNKFIAAQGPKPETVGDFWRMVWEHKCATIVMLTNTRERKEEKCYQYWPEQGCWIYGCVRVAMEDFTVLVDYTIRKFCHAAEGCRPPRLVTQLHFTSWPDFGVPLSPIGMLKFLKKVKSVNPAHAGPIIVHCSAGVGRTGTFIVIDAMMDMMHAEGRLDVFGFVSRIRKQRCQLIQTDMQYSFIYQALLEHYLFGDTELDIASLEGHLHKLHNTHTNMDRVGLEEEFRKLTNVRIMKENMRTGNLPANMRKNRVLQIIPYDFNRVILSMKRGQEFTDYINASFIDGYRQKDYFIATQAPLAHTVQDFWRMVWEWKCHSIVVLTELKEREQEKCVRYWPAEGSVSFGDYVLELKRDTLCETFSIRDMLLSYASEKQTRLVRQFHFHGWPEIGIPSDGKGMIDIIAAVQKQQQQSGNNPIVVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQTVKSLRTQRPHMVQTVEQYDFCYRVVQDFVDIYSDYANFK
The following text describes a protein:
Function:
Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTDTKEQSSLPEKDPAMDPDTTPTTPTSDLTSRNVSTGTGVLLGHYWGRSKEGSVIPGPATATVSSDRPKVIANDIDKADVRISILLLLASVLVRFYDLPNPPATIHEETAVGAYINKYIGRAFFPTSEPPLAFLMYYLVSLFFNYDGNFPFIKQDHIYVGSRVPYIELRSFAALSGVILVLSAYYTVRLGGGHKLGALIASFFVLFDTSLATTSRYIFAEPLYLMFVSLSLLFWKLFERQQPFSIKYYFWGLTLAVNLGVVVSTRWIGILTVLYVLVASCYNVFWILADLNISWWAYIKHITFRAVAFTLIPLAVYATVLQAHLLIASGPHDGDYLLAPAHQDAINKHRRPPVHADIVSGSVLTVRHLDTHSYLHSHDEFYPVGSRQQQISLYQHTDLNNVWVMENATKPNFEENDFLNNFKHGDSVKLRHLQSTRRLHSHEVKAPVSDNDYQFEVSAYGADGFPGDLNDMWSIEIVAQYSTPGLPSRQMRTLQTVFKLRHLIQKCYLYGHRTQLPAWGFAQQEVTCNRYPAGTGALWYVETNYHPNFPKEVNVTRDMIHYGNMTRVQKLKDMHNVIKVSREMTPDQSAFNTPPVSWPLGMAGLPFYRSHHRQILVIANLACWWFALASLAIYVLFKAVVFLRWQRGLQPVALSADLIRFDHEMGHALIAWACHFVPLIPETQAYTFITYLPAFYISCLAAGQMFSIFFKTFGRSKVIQVLVLAIVVVLAGGFYQEYRPIVAAKPWTREECKSHKYGLIDFDCDHYFATQEEYNVYDSQNIVNYVRFSEEMYQKLEGEATGPARPLQTLFKAREDKPNHDLGRPEVINAIRLHELERQNKHKEKAALEKSISAEIKKKAYAEAGIGEASEEEDWTDAEAAAAAPIDKKPTASYDDELQKKIQAQWARITDPPSLDLPDELKSQFNMSKFAKPKFEEVDLNDEDEYDDIMAAGDEEIAQEIKGEDIGHESIYEPPVYEEIIDVNTD
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.
Sequence:
EIPSQKKKKKVIKKKKVPAVPETLKKKRRNFTELKIKHLRKKFARKKLIYEKAKHYHKEYRQMYRTEIQMARMARKAGNFYVPAEPKLAFVIRIRGINGVSVAASSLRQIFNRTFVKLNKASVNMLRIVEPYTAWGYPSLKSVNELIYKCGYGKISKKRIALTDEALMAQSLGKYGIICREDLIHEICTIGKHFKEANNFLLPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN
The following text describes a protein:
Function:
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSLVVMATGGTGGHIYPAVATAKELRGRGYEVALMGQKGGMEEGIAEREGLTFYGVDAGKLARSGQGRPDPRQLLKAGQGLAQARRTLAGLNPAAVVGYGGFASLPGVLAAQSLGIPTILHEQNARLGLTQRLAVRRARAVGTAYDKVIGLDPRKATLVGMPVREERMPRAEALAALGLRDGPITIMVMGGSQGSLYLNQQVPGILWRLFGKVGKLRGKGDSVPPIDLDLRGPHLIENARSREVQVLHATGPRWLAEVQPKVENLPWYHVTGYVDAVAAWSVADLGITRAGTGTLAEAAFHGVPLVMVPLPESAENHQYHNAVAVEQAGAGRVVEQKVLPETLEKVVLECAAPGKRAAMRDAAQKRARPGAAARFADLIEVQLRRAPSPTAHAPTAHD
The following text describes a protein:
Function:
Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPLYRYKALDAHGEMLDGQMEAANDAEVALRLQEQGHLPVETRLATGENGSPSLRMLLRKKPFDNAALVQFTQQLATLIGAGQPLDRALSILMDLPEDDKSRRVIADIRDTVRGGAPLSVALERQHGLFSKLYINMVRAGEAGGSMQDTLQRLADYLERSRALKGKVINALIYPAILLAVVGCALLFLLGYVVPQFAQMYESLDVALPWFTQAVLSVGLLVRDWWLVLVVIPGVLGLWLDRKRRNAAFRAALDAWLLRQKVIGSLIARLETARLTRTLGTLLRNGVPLLAAIGIARNVMSNTALVEDVAAAADDVKNGHGLSMSLARGKRFPRLALQMIQVGEESGALDTMLLKTADTFELETAQAIDRALAALVPLITLVLASVVGLVIISVLVPLYDLTNAIG
The following text describes a protein:
Function:
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MVMAGRVVNKRRHMGLQQLSSFAETGRTFLGPLKSSKFIIDEECHESVLISSTVRLLESLDLTSAVGQLLNEAVQAQNNTYRTGTSTLLFLVGAWSSAVEECLHLGVPISIIVSVMSEGLNFCSEEVVSLHVPVHNIFDCMDSTKTFSQLETFSVSLCPFLQVPSDTDLIEEEHGLKDVASQTLTISNLSGRPLKSSELFKPQTKVEADKNTSRTLKNSLLADTCCRQSILIHSRHFNRTDNTEGVSKPDGFQEHVTATHKTYRCNDLVELAVGLSHGDHSSMKLVEEAVQLQYQNACVQQGNCTKPFMFDISRIFTCCLPGLPETSSCVCPGYITVVSVSNNPVIKELQNQPVRIVLIEGDLTENYRHLGFNKSANIKTVLDSMQLQEDSSEELWANHVLQVLIQFKVNLVLVQGNVSERLIEKCINSKRLVIGSVNGSVMQAFAEAAGAVQVAYITQVNEDCVGNGVCVTFWRSSPLDAVDRNNRIAILLKTEGINLVTAVLTNPVTAQMQTKEDRFWTCAYRLYYALKEEKVFLGGGAVEFLCLSCLQILAEQSLKKENHACSGWLHNTSSWLASSLAIYRPTVLKFLANGWQKYLSTLLYNTANYSSEFEASTYIQHHLQNATDSGSPSSYILNEYSKLNSRIFNSDISNKLEQIPRVYDVVTPKIEAWRRALDLVLLVLQTDSEIITGHGHTQINSQELTGFLFL
The following text describes a protein:
Function:
Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MVKFYTYSGETAAEALKIAQSHHGVDTLVFKTQEIRKKTLTSSGLYEIVVAVEEESENKPSKAPLIPESLYDEELNEEDVVMQLSSTVEEMRKLAGVSSSQRHYSFSKNKTLLEKDAPLEDAPLEANKQDALLQALKDEANHKKEREKREVKQEEEIKDINLQLSKIRDSLKLIQNMFWDEKNPNSINIPQEFAEIYKLAKQSGMKPSHLDEIMQLSLELMPLRMRENSVTIKRYFREVLRKMILCCPEDLNLRQKRILMLVGPTGVGKTTTLAKLAARYSRMLAKKYKVGIITLDNYRIGALEQLSWYANKMKMSIEAVIDAKDFAKEIEALEYCDFILVDTTGHSQYDKEKIAGLKEFIDGGYNIDVSLVLSVTTKYEDMKDIYDSFGVLGIDTLIFTKLDESRGLGNLFSLVHESQKPISYLSVGQEVPMDLKVATNEYLVDCMLDGFSNPNKEQA
The following text describes a protein:
Function:
Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). Component of a feedback loop involving atfs-1, atgl-1 and hlh-11. Promotes fat oxidation in response to mitochondrial stress. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Acts coordinately with lid-1 within the lipolytic cascade to distribute stored energy to tissues. Together with lipid droplet protein cgi-58, regulates lipid reserves as well as lipid droplet size and localization during the dauer phase in response to phosphorylation by ampk. May regulate serotonin-mediated lipolysis in metabolic tissues.
Subcellular Localization:
Lipid droplet. Cell membrane; Single-pass type II membrane protein. Cytoplasm. Note=Accumulates in the cytoplasm when phosphorylated and within lipid droplets when unphosphorylated during the dauer phase. Localization on lipid droplets enhanced by interaction with cgi-58.
Sequence:
MTMINSRPELMNLSFSGCGFLCVYHAGVAAAIKEYAPELLQNKILGASAGSIVACGLITGVCISHATSTILKVVSQARSRTFGPLHPEFNLLGIVRDELEVILPPNAYEMCTGRLVISLTRWSDHENVIIDEYRSNADLIDAIMCSCFIPLYCGITPPKFRGVQYIDGGVSDNQPIYDEHTVTVSPFSGESDICPPDWDSGSMLGVDFNGTSIRFTTRNMFRLMACLWPRSTDDLSRMCLQGFGDALRFLTKCGLAPCIRCLTIQTIDANEPAGRVSSECFSENDDAKKVTHVAVPRMKKRASANALNSFRTRGESECETCGDSDIPLEEVNIQSFFPSIMKKPFEDAVAAERSVFQYMMSFRLVRYATTAMGISKFPFDMALAFVKKVHQYLDMVSPPRWIMLKFRGLADFILGEVEKQKSRYTNFSCLVAVAETDSFGSVLASSTMEKEEHKEIELSEDAKKEMILLRERDRRRKLLKKAGKITPNNSENQFDETSVYDVDSFEHVIDFTKSHEALYEFHYRDENQVMKTFGLFTDSQQRPYSSASQHQHHHTKSLGGTSRLVHVPEEDEDAPLSAVSAPAVIFHGGQEIVELGESDKDSGLSGIDTKRKVPDEPTTRF
The following text describes a protein:
Function:
Part of the ABC transporter complex ArtPIQM involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MFQEYLSVIVKGIPTSLLLTVVSLLIAFFLALFLTFLLSMENKWIKSAVNLYLTLFTGTPLLVQFFLIYAGPGQFQWIIDSPLWYVLSNAWFCAALALALNSAAYSTQLFHGAVKAIPKGQWESCGALGLNRIQTLKILIPYALKRALPSYSNEIILVFKGTALASTITIMDIMGYARQLYGTEYDALTIYGIAGGIYLIITGIATLLLRKLEKKVLAFERFEVSKA
The following text describes a protein:
Function:
May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with microtubules during interphase. Detected at the mitotic spindle poles. Colocalizes with AKT1 at the cell cortex.
Sequence:
MRALPTLDSLARTRPSLGDSRAAEGTLTRQPANKSAVERLAADRAKYVRSTLGSSRGPVSENRVPEAPGVQHRNPIPSTLAPAPVARRAVARKPLRPDSLVIYRQKCEFVRGSDADSSRVGLMKKFFQGSGKDKMSVTPETTRVADEYKTKETEATWTKASQAAAAKPASMLPPPAPVVAMESPALPFEVAPRVPVRRSGVELRASRSKGLQRSQSDLSSRYSTARAESDTFFQYCGLDPEVVESLGRENFSAASDCVTPKMRSVSMATSDSSFSRHSEDGLQEEELLEQVPSTTSVVERNARIIKWLFTCKKAKETPSQKLQEPA