lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a component involved in the crosstalk regulation between light, hormone and abiotic stress response.
Subcellular Localization:
Cytoplasm. Note=Associates predominantly in the form of large cytoplasmic complexes.
Sequence:
MGVVEDTEPPLKRAKRLADEPNGFSANSSVRGSSVNSNSLGDLMARPLPSQGDDETIGSKGVIRKSEFVRIITRALYSLGYDKTGAMLEEESGISLHNSTIKLFLQQVKDGKWDQSVKTLHRIGFPDEKAVKAASFLLLEQKFLEFLKVEKIADALRTLRNEMAPLRINTKRVHELASSLISPSSFISHTTSTPGKESVNSRSKVLEELQTLLPASVIIPEKRLECLVENSLHIQRDSCVFHNTLDSDLSLYSDHQCGKHQIPSQTAQILESHTDEVWFLQFSHNGKYLASSSKDQTAIIWEISADGHISLKHTLVGHHKPVIAILWSPDDRQVLTCGAEEVIRRWDVDSGDCVHMYEKGGISPISCGWYPDGQGIIAGMTDRSICMWDLDGREKECWKGQRTQKVSDIAMTDDGKWLVSVCKDSVISLFDREATVERLIEEEDMITSFSLSNDNKYILVNLLNQEIRLWNIEGDPKIVSRYKGHKRSRFIIRSCFGGYKQAFIASGSEDSQVYIWHRSTGKLIVELPGHAGAVNCVSWSPTNLHMLASASDDGTIRIWGLDRINQQNQKKKLVQGSSSNGVIHRCNGN
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MPFHAEPLKPSEEIDMDLGHSVAAQKFKEIREVLEGNRYWARKVTSEEPEFMAEQVMGQAPNFLWIGCADSRVPEVTIMARKPGDVFVQRNVANQFKPEDDSSQALLNYAIMNVGVTHVMVVGHTGCGGCIAAFDQPIPTVENPGATPLVRYLEPIIRLKHSLPEGSDVNDLIKENVKMAVKNVVNSPTIQEAWEKARKGEFREVFVHGWLYDLSTGNIVDLNVTQGPHPFVDDRVPRT
The following text describes a protein:
Function:
Structural component of gap junctions (By similarity). Required for normal development of ovary. Required for normal egg production after blood meal. Required for normal development of testis; (Microbial infection) Modulates the development of Plasmodium falciparum oocysts.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Sequence:
MLEFVRPLQSILQIKQVNSTDLVWRLHCRVTVFLLLLASLLLSARQYFGNPIDCVIGSGTVSSSTMNEFCWIMGTYISNDPNFVLDSTDLVKINAKIGHIPESERSYQKYYQWVVFILALQACMFSVPNFLWKAWEAGRLQSLCDGLTTPIVPDHWEKTRKKQLITYLSADFPRLHRTYLLRYCFCTLLNFCNVLLNIFLVNVIFSGFWSNYHPAVKALLSFDFPSWNRYNSQVFPKIAKCDFHFVGPSGSKQNRDGLCLLPLNVVNEKIFAFIWLWFLGLLVISMLNLLFWIVVLCSKGFRLWLLTAPLYPIRTSYVARALDGQGVGQWFLLYQLCRNLNPIVGRELVQSVSKAKGHNGHKTFRMPKGGEPDFYTDPEGYDEEGV
The following text describes a protein:
Function:
Histone demethylase that demethylates 'Lys-9' (H3K9me) of histone H3 with a specific activity for H3K9me2 and H3K9me1. No activity on H3K9me3, H3K4me3/2/1, H3K27me3/2/1 and H3K36me3/2/1. Counteracts the DNA methylation of endogenous genes. Involved in the control of several developmental processes by protecting genes from silencing. Demethylates H3K9me2 in the promoter regions of RDR2 and DCL3 and mediates the repression of ectopic non-CpG methylation at RDR2, DCL3 and APC13 loci. Protects also a large number of transcribed genes from non-CpG methylation. May regulate gene expression via a pathway involving indirect silencing of gene expression through small RNA-directed DNA methylation (RdDM)-directed repression. Modulates stomatal development by regulating the methylation-mediated silencing of ERECTA receptor genes (e.g. ER, ERL1 and ERL2) and preventing cell divisions.
Subcellular Localization:
Nucleus.
Sequence:
MDSVEEEGVVRVEEENGRGGLRRHRRVSTKLANYVDPPTDDEEDGGPKRKGKRGGNRAPKKTPKKDEEMQKNEIDEANRVTGLVKEKRAATKILNRKDSIIEVGEASGSMPKEVKGIRIGKRKGEIDGEIPTKPGKKPKTTVDPRIIGYRPDNMCHQCQKSDRIVERCQTCNSKRYCHPCLDTWYPLIAKEDVAKKCMFCSSTCNCRACLRLDTKLKGINSNLIVSEEEKVQASKFILQSLLPHLKGINDEQVAEKEVEAKIYGLKFEEVRPQDAKAFPDERLYCDICKTSIYDLHRNCKSCSFDICLSCCLEIRNGKALACKEDVSWNYINRGLEYEHGQEGKVIEKPANKLDDKLKDKLDGKPDDKPKGKPKGRPKGKPDDKPKGKLKGKQDDKPDDKPDEKPVNTDHMKYPSLWKANEAGIITCCCGAGELVLKRLLPDGWISELVNRVEKTAEAGELLNLPETVLERCPCSNSDRHIDIDSCNLLKAACREGSEDNYLYSPSVWDVQQDDLKHFQHHWVKGEPVIVRNVLEATSGLSWEPMVMHRACRQISHVQHGSLKDVVAVDCLDFCEVKVNLHEFFTGYTDGRYDRMGWPLVLKLKDWPPAKVFKDNLPRHAEEFLCSLPLKHYTHPVNGPLNLAVKLPQNCLKPDMGPKTYVASGFAQELGRGDSVTKLHCDMSDAVNILTHISEVPNMQPGIGNLKKKHAEQDLKELYSSVANKEEMMEILENSRQQVQNVETDDGALWDIFRREDIPKLESYIEKHHKEFRHLYCCPVSQVVHPIHDQNFYLTRYHIMKLKEEYGIEPWTFNQKLGDAVLIPVGCPHQVRNLKSCNKVALDFVSPENVSECLRLTKQYRLLPPNHFAKEDKLGVKKMIVHAVDKALRDLSGEKSPEPEEKKQNMRGPKKGAAKAVAKALKDLSPSEKKSSEAAEEEISNGIVNAIDKGLKDLPPSEEKSSEAKVEISNGIVSAMDKDLEHISSSEKKSTEEEGVKRPNIVRTYERRKKLGSEVTNAYIDRLEMEKM
The following text describes a protein:
Function:
Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA synthesis (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity).
Miscellaneous:
MISCELLANEOUS: The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA (By similarity).
Sequence:
MKMEIVGDIKDSIVNENDLIFYYRSLCPINDLYNWLNYKNDIKGKYTKLNDPHFFSKREFSFTCKKSDQGKEEIYIRWLSFSNPEEFKNKLLSDLVPIKFDIGAIYNFPVSQKDQKGDIFLPVQKELIFDIDMNDYDDIRTCCTDKKVCKLCWKFLTVAIVLLDTALREDFSFEHILWVYSGRRGIHCWVADESCRYYTTDARAALADYLNILSGSDTKKKKVSIWGKDKYPMFERAFDICYKYFDVLMEEQDFFKKGSPHVQKLIDYLPYASGKVTDPLKAMKLNELKEYINNNNFNSREIFEKFSSIYNFLTPSNYFKRKNVSGNINMPSFVKEIVFHFTYPRLDINVSKEINHLLKSPFCIHNSTGRVCVPLDIKNINNFNPQSVPTLKLLREQFDDPKNSHIEAENRTSLKPYIDYFRRHFIENILLSCVEKKKRLNENSKYVDYNNI
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MASIKEELISAAESESQVMQIVQAALEGIDMDALTSMTPGLPQTVRQTAINSLLSSKKLAIQQAPGGVLRLKVNTSEQIAGTEEEQVIYSLIEESKTRGIWIKELREGSGLNQLQLRKTLKSLETKKLIKTIKAVGTTRKCYILFSIEPDMSLTGGTFYSDQQLDSELINTLISVCGSYAASRRKHAIDENPNNIQMQREASYIRPQEIAQFITEKRVLNVPLSLEDLERILEVAVLDGTIERRADGKIRACPPRSSISPLVSVPCAICPVVEDCRPGYVISPQSCDYMKNWLADL
The following text describes a protein:
Function:
Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Domain:
The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.
Sequence:
MDDWKPSPLIKPFGARKKRSWYLTWKYKLTNQRALRRFCQTGAVVFLLVTVIVNIKLILDTRRAISEANEDPEPEQDYDEVLGRLEPPRRRGSGPRRVLDVEVYSSRSKVYVAVDGTTVLEDEAREQGRGIHVIVLNQATGHVMAKRVFDTYSPHEDEAMVLFLNMVAPGRVLICTVKDEGSFHLKDTAKALLRSLGSQAGPALGWRDTWAFVGRKGGPVLGEKHSKSPALSSWGDPVLLKTDVPLSSAEEAECHWADTELNRRRRRFCSKVEGYGSVCSCKDPTPIEFSPDPLPDNKVLNVPVAVIAGNRPNYLYRMLRSLLSAQGVSPQMITVFIDGYYEEPMDVVALFGLRGIQHTPISIKNARVSQHYKASLTATFNLFPEAKFAVVLEEDLDIAVDFFSFLSQSIHLLEEDDSLYCISAWNDQGYEHTAEDPALLYRVETMPGLGWVLRRSLYKEELEPKWPTPEKLWDWDMWMRMPEQRRGRECIIPDVSRSYHFGIVGLNMNGYFHEAYFKKHKFNTVPGVQLRNVDSLKKEAYEVEVHRLLSEAEVLDHSKNPCEDSFLPDTEGHTYVAFIRMEKDDDFTTWTQLAKCLHIWDLDVRGNHRGLWRLFRKKNHFLVVGVPSSPYSVKKPPSVTPIFLEPPPKEEGAPGAAEQT
The following text describes a protein:
Function:
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MAWTSVLLMLLAYLTGCGPQPMVHQPPLASSSLGATIRLSCTLSNDHNIGIYSIYWYQQRPGHPPRFLLRYFSHSDKHQGPDIPPRFSGSKDTTRNLGYLSISELQPEDEAVYYCAVGLRSQEKKRMEREWEGEKSYTDLGS
The following text describes a protein:
Function:
Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes. Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases. Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity; Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity.
Subcellular Localization:
Lysosome. Secreted.
Sequence:
MWTLVSWVALTVGLVAGTWCPDGQFCPVACCLDPGGASYSCCSPLLDKWPTTLSRHLGGPCQAGAHCSAGHSCILTVSGTSRCCPFPEAVACGDGHHCCPRGFHCSADGQSCFQRSGNNSVGAVQCPDSHFECPDLSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKIPAQRSNRAVALSSSVMCPDARSQCPDGSTCCELPSGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCLSKENTTMDLLTKLPAQTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGTYQVSWMEKTLAHLSLPDPQALKRDVPCDNVTSCPPSNTCCKLMSGEWGCCPVPEAVCCSDHQHCCPQGYTCVAEGRCQRGSEIVAGLEKMPARQASLSHPRDMGCDQHTSCPVGQTCCPSLGGGWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLAHSPHVGVQDVECGGGHFCHDNQTCCRDNRGGWACCPYRQGICCADRRHCCPAGFRCAARGAKCLRREALRWDAPLRDPALRQLL
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. May be involved in the regulation of some light-responsive genes.
Subcellular Localization:
Nucleus.
Sequence:
MAASGKKVLAMSGNGENGDDPISNTHFSFGQLLDLGVINQYGQLLGEYSRLDEELWLSKPEPDDVVDNLDRSDDGVNHFATSPSEFVDKTVCDGGMATVKEKLTSLKDCSQNLSSPISVFQTKSSYSDDITTICSQSKCLPPTKHKFSGSLQFLGTTMSTREQRCGLQSESEYSMESLSDENEESIPSKSVRTRKISDLLDLDYDPAIKKCMHCETTDTPQWRTGPLGRGTLCNACGVQYKQGRLFSVYRPLRSPAFDPSLHSNLPKKVHEMRKGSSNEGDPNPPTPKPKKKKVEEMRMSNKSERDPSPTPKPKKVVPTPELKKVEEMRMGNYSEMARNLSFEQRKAEEMKKGNNSDMARDLSFEQRKAEEMILGNENERYQNRAHRAKKFEEMREKASNVVQSDSRKRNREFDSYPTVKRKLARKVAKKCLHCESTETPQWREGPMGRKTLCNACGVQYKAGRLFPEYRPLKSPTYNPSLHSHLPKKVLKMRMSSSENCATSGNHEKPA
The following text describes a protein:
Function:
Transcription activator involved in oxidative stress response, specifically during hyphal growth. Regulates the transcription of genes encoding antioxidant enzymes and components of the cellular thiol-reducing pathways including the mycelium-specific catalase catB (but not the conidia-specific catalase catA), thioredoxin reductase trxB and thioredoxin thiO. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific cysteine residues resulting in the alteration of its subcellular location. Activation by hydroperoxides induces nuclear accumulation and as a result NapA transcriptional activity (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Oxidized napA is found predominantly in the nucleus, while reduced napA is continuously exported to the cytoplasm by CRM1/exportin 1.
Domain:
NapA contains a C-terminal cysteine rich domain (c-CRD), but lacks the N-terminal CRD (n-CRD) found in the yeast homolog YAP1. It probably also contains embedded in the c-CRD a nuclear export signal, with which the nuclear export protein CRM1 may interact in the absence of inter- or intramolecular disulfide bonds (or otherwise oxidized/modified cysteines) within the c-CRD.
Sequence:
MADYNSLYQHGLYLSPDQQDLLLAALSSNNPPSKQKQNVQKPELGTNPTNTPGQASTGSFNTSPAFDGSHQFDNLNYDESPFLDFNPELEWDFPGSENLIGELPGSATSDDHEVGEKRKDSNSNGEVNGKKRRESDDKSDDKTSKKPGRKPLTSEPTSKRKAQNRAAQRAFRERKEKHLKDLEAKVEELQKASDSANQENGLLKAQVERLQVELREYRKRLSWVTQGNALSAINSYPGNANRMSGLNNNDFMFDFPKFGDLPGGRIFNGSVAKTNQNKKDDTPIPGILRHSALQAANGRASSSASPKTVTSNNPATKSPVTADGRLTSHTSSVYNYHQPGQGHDTSTSDSPSSSSDSHQFLSSSGTSPEPSVQSPDNQAKESHEGHTCTIDGEKSFCAQLGMACGNINNPIPAVRQRSESATNTPNAPSSTDNVPGIDFMAQQNGGQFDPLLFGDWREPQDAVLSQDFNTFFDDAFPLPDLGSPSHNLTEVGLGAQQKKSILEEMDNKEEEEVVPGEDKAQMLSCTKIWDRLQSMEKFRNGEIDVDNLCSELRTKARCSEGGVVVNQRDVDDIIGRV
The following text describes a protein:
Function:
Alkaline phosphatase that can hydrolyze various phosphate compounds.
Miscellaneous:
MISCELLANEOUS: In most mammals there are four different isozymes: placental (ALPP), germ cell (ALPG), intestinal (ALPI) and tissue non-specific (liver/bone/kidney) (ALPL/TNAP).
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MWGACLLLLGLSLQVCPSVIPVEEENPAFWNRKAAEALDAAKKLKPIQTSAKNLVILMGDGMGVSTVTATRILKGQQQGHLGPETQLAMDRFPHMALSKTYNTDKQIPDSAGTGTAFLCGVKTNMKVIGLSAAARFNQCNTTWGNEVVSVMHRAKKAGKSVGVVTTTSVQHASPAGTYAHTVNRGWYSDAQMPASALQDGCKDISTQLISNMDIDVILGGGRKFMFPKGTPDQEYPTDTKQAGTRLDGRNLVQEWLAKHQGARYVWNRSELIQASLNRSVTHLMGLFEPNDMKYEIHRDPAQDPSLAEMTEVAVRMLSRNPKGFYLFVEGGRIDHGHHETVAYRALTEAVMFDSAVDKADKLTSEQDTMILVTADHSHVFSFGGYTQRGASIFGLAPFKAEDGKSFTSILYGNGPGYKLHNGARADVTEEESSNPTYQQQAAVPLSSETHSGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAACLEPYTDCGLASPAGQSSAVSPGYMSTLLCLLAGKMLMLMAAAEP
The following text describes a protein:
Function:
Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle.
Sequence:
MSFVRVNRCGPRVGVRKTPKVKKKKTSVKQEWDNTVTDLTVHRATPEDLVRRHEIHKSKNRALVHWELQEKALKRKWRKQKPETLNLEKRRLSIMKEILSDQYQMQDVLEKSDHLIAAAKELFPRRRTGFPNITVAPDSSQGPIVVNQDPITQSIFNESVIEPQALNDVDGEEEGTVTSQSGESENENELDNSLNSQSNTNTDRFLQQLTEENSELISKLWTDIQQKIVTQSQITPPGTPSSALSSGEQRAALNATNAVNRFQTRLQPEESTETLDSSYVVGHVLNSRKQKQLLNKVKRKPNLHALSKPKKNMLSGSTTSADLPNRTNSNLDVLKHMIHEVEHEMEEYERWTGREVKGLQSSQGLTGFTLSLVSSLCRLVRYLKESEIQLRKEVETRQQLEQVLGDHRELIDALTAEILRLREENAATQARLRQYMVTTDEQLISLTHAIKNCPVINNRQEIQASESGATGTRVMDSPEGPVVNANVSVPLMFREEVAEFPQEQLPVKLSQVPDPPDKMNLAKNFPAHIFEPAVLLTPPRQKSNLKFSPLQDVLRRTVQTRPAPRLLPTVEIIEKEQNWEEKTLPIDTDSQNSSEENRLFTQRWRVSHMGEDLENKTQAPFVNLSQPLCSSHSNTQQSRSPTFSEELPVLGDGQQLRTNESLIQRKDIMTRIADLTLQNSAIKAHMNNIIDPRGEQGDGLRELNKQESASDMTSTFPVAQSLTPGSMEERIAELNRQSMEARGKLLQLIEQQKLVGLNLSPPMSPVQLPLRAWTEGAKRTIEVSIPGAEAPESSKCSTVSPVSEINTRRSSGATSNSCSPLNATSGSGRFTPLNPRAKIEKQNEEGWFALSTHVS
The following text describes a protein:
Function:
May have a role in sperm development and fertilization.
Subcellular Localization:
Secreted.
Sequence:
MPRLLRLSLLWLGLLLVRFSRELSDISSARKLCGRYLVKEIEKLCGHANWSQFRFEEETPFSRLIAQASEKVEAYSPYQFESPQTASPARGRGTNPVSTSWEEAVNSWEMQSLPEYKDKKGYSPLGKTREFSSSHNINVYIHENAKFQKKRRNKIKTLSNLFWGHHPQRKRRGYSEKCCLTGCTKEELSIACLPYIDFKRLKEKRSSLVTKIY
The following text describes a protein:
Function:
Low-affinity proton-dependent bidirectional nitrate transporter. Involved in nitrate loading into xylem and not in nitrate uptake. Not involved in histidine or dipeptides transport.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSCLEIYNKDTMKKKEGEEETRDGTVDYYGRPSIRSNSGQWVAGIVILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGLSSLSLSSYMFLIRPRGCGDEVTPCGSHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEGYSKIAFFSYFYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRYFKPTGNPLSRFCQVLVAATKKSSVEAPLRGREEMYDGDSEGKNASVNTGRRIVHTDEFKFLDKAAYITARDLDDKKQDSVNPWRLCPVTQVEEVKCILRLMPIWLCTIIYSVVFTQMASLFVEQGAAMNTSVSDFKIPPASMSSFDILSVALFIFLYRRVLEPVANRFKKNGSKGITELHRMGIGLVIAVIAMIAAGIVECYRLKYADKSCTHCDGSSSLSIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMMSMSMGNFVSSLLVTMVVKISTEDHMPGWIPRNLNKGHLDRFYFLLAALTSIDLVVYIACAKWYKPIQLEGKDEMQDMSDDDYDTESEEEREKDSKV
The following text describes a protein:
Function:
Involved in mitochondrial potassium homeostasis through the mitochondrial K(+)/H(+) exchange regulation. With MBA1, plays a role in ribosomal translation and protein insertion into the inner membrane.
Miscellaneous:
MISCELLANEOUS: Present with 7390 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Domain:
The matrix-exposed C-terminus contains a 14-3-3-like domain which is necessary and sufficient for interaction with mitochondrial ribosomes.
Sequence:
MLNFASRASCVTRRQASLYFVKNQGPRLIASTIPSCHWPLRAQGVQPNYPLSLRFYSTDKSKSVTKPVAPTSTDAPAKPKETLMVKVKHALKHYANGTKLLGYEIKVSTKLLIKFAQGYELSRRERNQLRRTMGDVFRLIPFSAFLIIPFAELFLPFALKLFPNLLPSTYESGKDKQAKRNKLIEIRKKTSEFLHETLEESNLITYNTIENAEKKQKFLNFFRKLYSAKEGKIMTFQHDEISAIAQMFKNDSVLDNLSRPQLAAMSKFMSLRPFGNDNMLRYQIRSKLKDIMNDDKTIDYEGVESLSQEELYQACVSRGMKAYGVSKEDLVDNLKVWLELRLRQKIPSVLMVLSSTFTFGGLPKENYSKAFSPLAEKKETKSKYDDLLDLYYDGILQVLSSIPDPVYNVAKLDVSESKSSAAETEAEKQVAEKKIKTEEKPEETAIPKEEATAKESVIATTASAVTPKLVVVNEKAETAKTEEISQEKENAEPTDSAEATEAEEKKTSDDNEFKLNVLKEQEELIKKEEEEAKQRASREHVPDDINLDEEEEAKSVPPIPADQAAKTFVIKKD
The following text describes a protein:
Function:
Throughout most of the cell cycle it forms a double ring that coincides with the septins. After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Mediates cytoskeletal rearrangements required for cytokinesis. In conjunction with the medial actin ring exhibits contraction-like action.
Miscellaneous:
MISCELLANEOUS: Present with 195 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton. Bud neck.
Sequence:
MSYSYEACFWDPNDNGVNILLGHISQGIRSCDSMILFFKQRSELEKDYARRLGAITGKLDKDIGTNMDYGKLNETFNVVLSVEKARAQSHSKQSEILFRQIYTDTKAFAANLQARYTTLSGKIERLRMDKFNKKKGCEVLQKKLQDAQIRFRDLQLNENNMIGAKRVEHNKRELLKWESNSQEYKVQLDVLKQEYKASQKFWIHEWAQLSCELQEMENARISFLQSKLQQFATSSMETYILEQTKMDMLTNHLNSFTAADEISTFSKENGTGRLKHKTSKGDMNSSANWAQMSSISTTSKKTESYMDNIRKLSSQLKETENKRKLASIDKYEKPLPSPEVTMATQFRNSTPVIRNETKVVANPTLSLRSSPVQLQSNVDDSVLRQKPDKPRPIVGEEQLKPDEDSKNPDEKGLMVHKRNQSLSSPSESSSSNPTDFSHIKKRQSMESMTTSVSSMANSIDDSQRFAKSWNSSNRKRKSMSHLQVPSSASSRSDDGGRTPNSAHNLNEDDYNTRRDTSTSTILFKPPVAVRGTSRGHTHRQSMIMQDSSNPIEDALYEMERIQSSSKPGTKTGNIMDERGVVRDRGITVTLPIVTSEGFPVIEYAKAMYPLIGNEAPGLANFHKGDYLLITEIVNKDWYKGEVYDNDRIDRNHRIGLIPYNFIQLLHQGL
The following text describes a protein:
Function:
Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. Mechanistically, captures transport vesicles arriving from endosomes via the protein TBC1D23. Recognized vesicles are then tethered to the trans-Golgi before subsequent SNARE engagement and vesicle fusion. Selectively regulates E-cadherin transport from the trans-Golgi network in tubulovesicular carriers.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane.
Sequence:
MFTKLKKKIAEEAAVAPRPGGAARIPRTISRESITSAGADSGDDFASDGSSSREDLSSQISRKNEQIRRLEAKLMEYAEQVRNLQKMKDKLEVALEKHQDSSMRKFQEQNEAYQANRAKMAEGFALALEKKDQEWMEKLADLEEEKKKLSDQLVSMTKQNMSFFKKREDLDELEGFQQQELAKIKHMLLQKEEMLWKIEEDLKRQREEAEASLVELQDSSCLSAKLSADIQKLQEENTELAQKRSELVAAQEGATIKITELEDRQTELQDFIQRLSLDLQEAQSSASSCKKKLNSVQADYEDLSLQHSQLKAKMSTEAESKEVLIMRLQEKVSSLEKTLDGTYSGEEGLQALLKEKNDLEVRLNESKQELLEGKAMHKDTICQLENQAAKLTSRIQEMENVLHQKDEELTLFKQKSASELKEIEQKLETTHEKLQKQEEELNERESQIKSLQSDLESECSRLTQQLNSVKHQCAEKVERLEAQVSALEGAREFDKAAAQHQVKQLEQDNTLLKERNEELERALRHQEAEQEKMREELSSRETVSVEIAKALEETRKQKEELQQQVASLSNIITENEKELAQRTEALQGKEEEAASLKRDYDAILLQVSQHQSQLETYKTQMEQSEESTEKQVRTMRMQLQEHKQALLTSESQVSSLQEEVSALHEHLHGSNAQELNGDVTAGDIAQLQKENLEMGQQIAEKNKTIKQLQQRMAELKKTLQKELKIKPEPEVNEVQEKQNPEPALPSLTVTNNADLNDSREINFEYLKHVVLKFMSARETEAFHLIKAVSVLLNFSVEEENLLKETLEYKMSWFGSKPAPKGAIRPSISKPRTPWS
The following text describes a protein:
Function:
Required for optimal fertilization at the stage of sperm-oocyte fusion, plays a role in optimizing acrosome function, the translocation of IZUMO1 during the acrosome reaction and the fertilization process. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome. Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Membrane raft. Secreted. Note=Located in the connecting piece of elongated spermatids and sperm. Also located in the apical region of the sperm head after sperm capacitation (By similarity). Weakly attached to the cell membrane and later secreted into the extracellular space (By similarity). Located on sperm equatorial segment and neck (By similarity). Associated with epididymosomes from the caput and cauda epididymis (By similarity).
Sequence:
MALKNKFSCLWILGLCLVATTSSKIPSITDPHFIDNCIEAHNEWRGKVNPPAADMKYMIWDKGLAKMAKAWANQCKFEHNDCLDKSYKCYAAFEYVGENIWLGGIKSFTPRHAITAWYNETQFYDFDSLSCSRVCGHYTQLVWANSFYVGCAVAMCPNLGGASTAIFVCNYGPAGNFANMPPYVRGESCSLCSKEEKCVKNLCRTPQLIIPNQNPFLKPTGRAPQQTAFNPFSLGFLLLRIF
The following text describes a protein:
Function:
Located at the top of the head of the small subunit, it contacts several helices of the 18S rRNA.
Subcellular Localization:
Mitochondrion.
Sequence:
MKYEKPMARFYAKFIKKIKSSLNDNIKVNKLTRYQIDRIIKIISQNYFVDLELVKVIQRDIKQLMSIGCYCGFCHNAGLPLCSQRTHTNAKTYHKVRNVSINQQS
The following text describes a protein:
Function:
Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential while decreasing mitochondrial reactive oxygen species. Increases mitochondrial respiration rate. Increased mitochondrial respiratory activity promotes myogenic differentiation which facilitates muscle growth and regeneration (By similarity). Increases mitochondrial calcium retention capacity. Plays a role in maintenance of cellular lipid composition through its interaction with cytochrome b5 reductase CYB5R3 which is required for mitochondrial respiratory complex I activity (By similarity). Interacts with the mitochondrial trifunctional enzyme complex (MTE) and enhances fatty acid beta-oxidation. Not required for MTE formation or stability (By similarity). Modulates triglyceride clearance in adipocytes through its role in regulating fatty acid beta-oxidation and lipolysis.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Note=Preferentially binds to cardiolipin relative to other common cell membrane lipids.
Sequence:
MADVSERTLQLSVLVAFASGVLLGWQANRLRRRYLDWRKRRLQDKLAATQKKLDLA
The following text describes a protein:
Function:
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (By similarity).
Subcellular Localization:
Chromosome, centromere, kinetochore.
Sequence:
MWERLNCAAEDFYSRLLQKFNEEKKGIRKDPFLYEADVQVQLISKGQPNPLKNILNENDIVFIVEKVPLEKEETSHIEELQSEETAISDFSTGENVGPLALPVGKARQLIGLYTMAHNPNMTHLKINLPVTALPPLWVRCDSSDPEGTCWLGAELITTNNSITGIVLYVVSCKADKNYSVNLENLKNLHKKRHHLSTVTSKGFAQYELFKSSALDDTITASQTAIALDISWSPADEILQIPPLSSTATLNIKVESGEPRGPLNHLYRELKFLLVLADGLRTGVTEWLEPLEAKSAVELVQEFLNDLNKLDGFGDSTKKDTEVETLKHDTAAVDRSVKRLFKVRSDLDFAEQLWCKMSSSVISYQDLVKCFTLIIQSLQRGDIQPWLHSGSNSLLSKLIHQSYHGTMDTVSLSGTIPVQMLLEIGLDKLKKDYISFFIGQELASLNHLEYFIAPSVDIQEQVYRVQKLHHILEILVSCMPFIKSQHELLFSLTQICIKYYKQNPLDEQHIFQLPVRPTAVKNLYQSEKPQKWRVEIYSGQKKIKTVWQLSDSSPIDHLNFHKPDFSELTLNGSLEERIFFTNMVTCSQVHFK
The following text describes a protein:
Function:
Involved in cytokinin-mediated development. Promotes the expression of cytokinin synthases (e.g. IPT3 and IPT7), thus triggering the accumulation of trans-zeatin riboside, trans-zeatin riboside monophosphate and isopentenyladenine 9-glucoside.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.
Domain:
Domains SOFL-A and SOFL-B are required for function in cytokinin-mediated development.
Sequence:
MESANIFGSDEDCRSCESGWTMYLASQSHDRDDDCYYGDDDEEEEDSDGGDSMDSDASSGPMEATSYLKLAQEIEEQNSIKKKKKKTNEEMVLVETTRVHNNINHDDDDDDDEDDGDNHDYDDGNDSYSVVHSYVGSVRQKGLV
The following text describes a protein:
Function:
Exhibits a non sequence-specific DNA-binding activity.
Sequence:
MAEEQKTSKVDVESPAVLAPAKEPTPAPVEVADEKIHNPPPVESKALAVVEKPIEEHTPKKASSGSADRDVILADLEKEKKTSFIKAWEESEKSKAENRAQKKISDVHAWENSKKAAVEAQLRKIEEKLEKKKAQYGEKMKNKVAAIHKLAEEKRAMVEAKKGEELLKAEEMGAKYRATGVVPKATCGCF