lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGLTKQYLRYVASAVFGVIGSQKGNIVFVTLRGEKGRYVAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEEREMEREAEYEESVAKEDQPAVPGETQGDSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHKAICKAAGKEVPLPSNPILMAYGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILKLFNEFIQLGSDVELICRCLFFLLRIHFGQITSNQMLVPVIEKLRETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLILTLT
The following text describes a protein:
Function:
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for DNA replication during mitosis and meiosis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of cdt1 and spd1. Involved in the regulation of mitotic and pre-meiotic S-phase progression.
Subcellular Localization:
Nucleus.
Sequence:
MNMDIGKALSDVGGLRDITSRANNSLPPTPDSSPAAPSKKHKLYDFLESRGKIETPRKRIVFEKKPLLHKPVHIQKKPAQLCKELLIRQLGGSRSHPFSTKTSRHVGGRLNLETYYSRPSECLMMLNQLPFCLGFANNESLLAVCTETGALELFDSRFYDRQNEENQPSARRIHGWLAHNNAIFSVNFSKDDSLLATSSGDQTSKVFDLSTQQCITRLGRRGVDGYHSHSVKQVNFCNDSPYNLVSCSRDGSIIFWDMRTHGITIDGEHFQKPVLRIRKAHENSGRDCSITSATWLPQSTSQVISSCSANSALKLWDLRTVHTVRPLPAATTPELTTSKRDFGVTNVCTSPDGERIYAASRDSIIYEYSSRHLNSGFCKTYKDPRLRISSFYVKLACSPDGATLACGGGVQDKTSGVVVFDTTRNCSSSAMLTGGHTKDVTAVDWSSEGQLASISDDGSVRVWNSSLHGSAANLREKNFSEIFYWGFSEK
The following text describes a protein:
Function:
Seems to act as a chloride ion channel (By similarity). Plays a role in retina development.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Within the endoplasmic reticulum (ER), localizes to the mitochondria-associated ER membrane, a zone of contact between the ER and mitochondrial membranes.
Sequence:
MKLSSSSSFGLCILVVFFCFVVIESAKIRIDGYNDEAWIDPYDMLNYDPTTKRMRKSTESESYQNVPTKRREFNSESCDVPKCPDEHECIKKLHILQKEFDEQKSKSTATLSKPVCLPVFKRFLSKLLKETSKLGLPDDGITAMHYDAEVKLSKQSLAEIQKLLNDEDGWTTGAMDEALSQILVQFKLHDYEAWKWRFEDTFHVDVDTVLKVSLIVLIIVAIICTQLWSVVSWFVQFRRMFAVSFFISLIWNWFHLYMLAFAEHKKNIVQVESFNAKCTGLKQLNWQDSLSEWYRRTWTLQDDPCKKYYEVLVVNPILLVPPTKAITITITNFITDPLKHIGEGISEFLRALLKDLPVTLQIPVLIIIILAILIFVYGSAQAAIHQVARFPRLGWRQEQPPPAVGQRQNPQLRAHEEPWEGGDARQPLPMRQDNRGNHVGNRGDQGFRDANAPENREEDRSMDIRQEFSTKRTPVETLQATGNTFPDDETDSQQRTQELDSGANVEEEVKVEEKEKKESFSVDNKEQKETKSPDRSEPITSEPPSSIDVKTVGADQGNEHLMCTKRKWAAQNGFKLQVILCEINSEASADLPEEEECFSFKHPVQETQS
The following text describes a protein:
Function:
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built; The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MSYPEASPSTPQLFSTLKKDNYFDLDDIIVCQEKVTCTFQSTVHRLGYIDPGSNKEDIQEDAKMELPYWLAKALCTRKRKIVSIEYPNVYRSSYLQILAADANVVDLHKWGPSYYRLGEKLFNFEHDESRPLAEGLLQAFISRFRKVMDSSQNAQYQDTYQLTEKLDEIERKIFKSTRQNVEDFERWQVGKSNQLSTSEAILSHRKRKHTDDNVS
The following text describes a protein:
Function:
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MESFIREQLKLLVGTNNSVGIRDKFDATFIIICLIMKKHEFRLHPQPEPNDPNNINNEPNTSLECAKNTLPKDWNKSDDSFTVDFSHDLTPLKKYHIKCLRMGTLLLVNAMIKDKQDKICTLDIDIEKLISNTNFSDVENLLTNLKEFIAIYEFNIINQLVPGLIRVPNGSPQVTTTSAPNTNNQRAPPQRYNDDYDDPLRIGPPQRPPRFIGDHGRGVGDPDLYPPGFPQFGNQPFLPPNRVFPGGGSYIGRDHPGFGDIHNPYRDSNDPYGQGLPGWEQRMPRGAVPPGARFDPFGPPTGGNINNNRGNRNNYGGPDRDDFGPPGFSPNGFI
The following text describes a protein:
Function:
Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.
Sequence:
MLNLIITADDYGYNSERNLGIKYCLENGAVSRTSAMVNGLACLSGRDILNNLPKKATVGLHLNLTEGRPLQCHSSLRQYGFFSSKQSLTMLLDDDDVIKKSEVKSEIILQINKFKELFGLYPPYVDGHHHVHVFPGIVRDVLASVMSELNIREVRMPHDGTFDEARDDATLNETADGSLRDFLMSVNTEAEKAKSVYKHHSIKFSDHFFGLSTMGLMMTEDKIKNILLKMRSEATNSKTPNKITTCELMAHPGYPCTDPTRGGCGEGADQFAQSTDRLHELNVLNSTSLKQFYRDNNIHLISLVSS
The following text describes a protein:
Function:
Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis.
Subcellular Localization:
[Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane; Single-pass type I membrane protein. Note=In the anterior acrosome region, enriched on the inner acrosomal membrane but minimal on the outer acrosomal membrane; in contrast in the posterior acrosome region enriched on both the inner and outer acrosomal membranes; [Isoform 2]: Nucleus. Cytoplasm.
Sequence:
MDFILLIILSGVFLPDIISLQPIVGQEPGVTLSDEEQYYADEENNTDGNSVALHKLEENEMDTPANEKTGNYYKDIKQYVFTTPNIKGSEVSVTATTNLEFAVKKNYKASKPTASGEEEKPSESSRKTSTPNIPAFWTILSKAVNETAVSMDDKDQFFQPIPASDLNATNEDKLSELEEIKLKLMLGISLMTLVLLIPLLIFCFATLYKLRHLRDKSYESQYSINPELATLSYFHPTEGVSDTSFSKSADSNSYWVHNSSEMRRSRTRRSKSKPMDFSAGSNQTVLTDESSFLPPEETRFLLPEEPGKELIVERGPMQAMNEIDAQLLLNKEGSPSN
The following text describes a protein:
Function:
Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSQSDTTVSTRFSLLPGSITRFFLLLIIVLLVTMGVMVQSAVNAWLKDKSYQIVDITHAIHKRVDTWRYVTWQIYDNIAATTTPSTGEGLQETRLKQDVYYLEKPRRKTEALIFGSHDSATLEMTQRMSTYLDTLWGAENVPWSMYYLNGQDNSLILISTLPLKDLSSGFKESTIGNIVDSRRAEMLQQANALDERESFSSLRKLAWQNGHYFTLRTTFNQPGHLATVVAFDLPINDLIPPGMPLDSFRIEPDATQATGRSSEKEAPDSVTISFNGSKIEISSALNSTGMRLIWQVPFGTLLLDTLQNILLPLLLNIGLLALALFGYATFRHQPGRSTESTSGNAANNELRVLRAINEEIVSLLPLGLLVYDQEGNRTVISNKIADHLLPHLNLQNITSMAEQHQGVIQATINNELYEIRLFRSQIAPRTQIFIIRDQDREVLVNKKLKQAQRLYEKNQQGRAAFMQNISNTLKEPVRQLAVNAAAVTTPESLKLADQADVLVRMIDEIQLANMLENDAWKSEATLFSLQDLIDEVVPEVLPAIKRKGLQLLINNHLSGNDERWGDRDALRRILLLLIQYAVTTTAMGKITLEVEQDESIAERLTFRILDTGEGVTLNEIDNLHFPYMNETQGDRYGKANPLTFWLCNQLARKLGGHLNIKARETLGTRYTVHVKMLPHDQHTQVEERLLDDVSVMVDVTSNEVRAIVLRQLENWGATCITPDERQISQEYDLFLTDNPSNLTASGLLLSDDESGVRKIGPGQLRVNFNMSNAMQEAVLQLIEEQLAQEEIPASPLGGDENAELHASGYYALFVDTVPDDVKRLYTEAATSDFAALAQTAHRLKGVFAMLNLVPGKQLCETLEHLIREKDAPGIEKYISDIDAYVKSLL
The following text describes a protein:
Function:
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRKRINLLREFSVPLIAGVVVALLWANLDPAGYHSFIEQPFFGGMSFHFVVNELFMVLFFGIAAVEITQSCLPGGDLNPLRKAVNPLLATLGGVVGPVLVYLGLNAIIGGPELTRGWGIPTATDIALAWLVARLVFGAGHPAVSFLLLLAVADDAIGLAIIAVFYPDPNHPTEPIWLFLTVAGMVVAYILRSLKSRSYWPYVVVGGGLAWTGLFKAHLHPALALVFIIPFLPHPSRETAHLFEADPRDTSTLARFEHDWKIVVDFGLFMFGLANAGVGFSSVGAATWLVLASLVIGKTLGIFAMGYVGRALGFPLPQQVGAKELAMTGLVAGIGLTVALFVAGVAFVEPDIQGSAKMGALLSGGVSIVAIMLGRALNVRRIP
The following text describes a protein:
Function:
Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (Probable). Does not bind DNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVTKQLLQMQADAHHLWVKFHNYHWNVKGLQFFSIHEYTEKAYEEMAELFDSCAERVLQLGEKAITCQKVLMENAKSPKVAKDCFTPLEVIELIKQDYEYLLAEFKKLNEAAEKESDTTTAAFAQENIAKYEKSLWMIGATLQGACKM
The following text describes a protein:
Function:
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
Sequence:
MANRIKKGDQVVINTGKDKGKQGEVVRVEGDRVIVSNANVIKRHTKPNPQAGVAGGVVEREASIHISNVNIVNPATGKGERVGFKVLEDGRKLRVFRSSGEALDA
The following text describes a protein:
Function:
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
Subcellular Localization:
Nucleus.
Sequence:
MPKRKIDGEKGAKGKEEPTRRSARLSAKPAPPKPEPKAKKAAPKKAAKGKKGSNPAENGDAKADQAQKVDATGDAK
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MALQWYLLGAIAVVEAAVLLLLSAPLPPRLSKQVLEFVKRILQPGLAVVPFALFQLLEVYWKYENRINCSKQECSPFERDRFQRTLFKSHRNALLAISAAFFYWLLFRIAKMQQDLLQAENRVKLAKEK
The following text describes a protein:
Function:
Probable chloride channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIQFIINTLHAIPHFNFHFQRIKPTFVLNIESEYTQSLALICGLVLSISLLLLLTIIITWVCQCCARTDTTVKPRRKVKRLSVILFILSVFCFFFLGFCLFGNDRINRGVQSSIVSLNDVNNQIKIGIATGGQLTEISRNASTHIKNLEHIVLEKSKKPGTNQTLISEIDTLLTSLSDSIDSVLKRLDTLKKDFGNQSVLEKTKNLAELIEFERWLLLVILLSIMLCVLFAGVISFCRQSKKGAVGFSGVGILIFIVCWALLAVVLPLAVALADFCGQGGDFLADTVSQPVLKSLAFYSECDPRPTHDNLPPHLGISNMSDELSNMQGVKTKLDSLMDTAFNQSEEVQKASSFLLDDGTRSLKMIGALENSFACYAYKDDLRVMKEGICGQAVVGSAVLTLCLILLALFMFTLLLIVSKSWNLFTRLRVGLRANGVSIISPRSMGNDDSLVSPSTIERQYTSLSKKIPTAIDVVVEALSLWKRSALEHAIVEQMAYQRQLANAKYRVLCGVCGNDYVEVDEDDPFFPRNAADTNIPVDIYGTHMYNPRTRERTEPSTGTTTATANGGETDPLWSRAPVAGNSSGTAVRAPYDDRYNDYNDHYNV
The following text describes a protein:
Function:
Probable transcription factor that acts downstream of egl-15, to promote migration of the HSN motor neurons from the tail to the gonad primordium during HSN cell differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MPYRAELKRPDLKGSFPCSICQKVFCHSSSLSRHRMQAHFKSYTCTTCNNEIPSNDTLRSHMYRVHNITRMFMCRCCNWAFPDKTSLHIHMQSMLKNGTPGEAAVLAKSSDVVDSTSESGSPRQSPPFSPDLLMQKRMLQVAANNNNIGSIFPTLLKSPDSKSMFPLDLSNMGPSQFLSAWLANNPINTAALNLAAQQTPSKDSIQSSNISDYDDLEVQTTEEDIKFEVESSDVSPRSVIVKTEPTFKRELEHDADIDVEGDDGEPPLKMTIDDKNIHISHDQPSPTVSDSHISGGSSSHSGESLKCFDCQVARGKLVAVEDKCRAYEKTIRELQVQVDFLRKIQPNPMPPVMLPPPMMPMPSPGPNNLFQNPAMRMLLNNLIHMNRPSVVP
The following text describes a protein:
Function:
Probable carboxypeptidase.
Subcellular Localization:
Secreted.
Sequence:
MMKLLFIIISIIFVINVSNSTPTLQLSGYFNVNETTNANLFYLFYESQNSPSTDPLILWLTGGPGCSSLMAAFYENGPYFVNDNLTLSENPNSWNMVANVLYVDSPLGAGFSYVVDSDGYSTTETEISENLYSFLTQFLSKYPKYSKLPLYIFGESYAGHYVPSFSYYIYQKNLGLATINLKGLAIGNGMVDPYIQYGSLGPFAYAHGMLDINALKETEGLYESCQQAIDSGDYNMTTQICNNIMDIVQEYAGNFNVYDVSKTCYPNEPLCYNFTAIIDYLNLASTKQSFGVLPNSTWNVCSTQPYSAIIRDWFNTPINYIPTLLENYKVLVYNGNYDWICNFLGSTEWTSQLKWKYNQEFNNSPRKILYINGNTISGYSQSYDNLTMQVLLGASHMAPREAPVAALAMVESFIQN
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MFTNVFRIGGLQQVSWFQLIAEGESLSPKISIGEERSQQDVAAMQVIRAHMWLQEAGTLSSWTLSDSKVKLWLFLPGRHDGLNPRVHAAVAGLKVVGSGLWRAPGECTEVGFALDQALRNRIEKGFQTVSYVRFGDVFVKCLRQSSSELNLRKSLFSCELVFTASNDAIFVHVFVRRKRVRQLAISDLQAALAQQRSNLGMCDNSLAVIVAPNGLSGLLTGCSPDDLVTQLYKSKIQAYDASSLPFHVVGSTSATGTTPVQMCYAEVLLDQLSGSTRATRSSAPEASETKSHGKAFNSADGGHVLIYPLDAVLAPMRSEVPTHPFIRRCWFQDWAGATWLEDGMNEQVPPLNSKNGLDGGESREKSTITEFGANGSVPGHSSGPGTSSNSSGGSTSSSSQGSSGTSSSSDADGDGLGEIEADGDSLGSKAAGVLASKHGPSTSLQGLDMDTSDMKNSLGYSQGTKRGRQVKPTAAFDFPSKALKRSNSIGNDVLELVDGPSNDKKGAGFLGESSGFGGGIMGAGTPRGGGSQSGNPWDQWDNNDTFGMGLGMDIQSDADILAEFGDFGDFFEDDGLGFGEPPDTAESQALMFTLPDYGEVSQTPGTAPLDASDPLVLPILDFPMLGKDQSTGDLLSEMKPITSMEVSQAPIGVPPSPTQQPLELNLRLKSEAMLCFASGFEPVDMTGVPDVGVSTLRDPYVPASKRKAVESVQKETYQYSATPVSYPSIERKDVGKDEQGSTKSPNDFGDSKKKKELTADYIVVTGSHGSKHVNGKLPTTDDKGPDRAAGMTLLSNKQPADISGGGGNGTQIPGNSLAAHSPSSLKHKDGKKSPTRSSVAVLATELECALLQVMICRAQDSSSSNSGNSGAASPGNEAARYSPLPSKDSGSEITQVQSDTLAQSTSGLGKPHQERQKKVPERIAGFADDDMQDGGSRVAQVGVWRPVGVPNPLRSSNTISSKYANAVDLPVGVSNTSPIDPTMDDVMGSAERQCQWQEILEAVPLLAQQASTAVDVSLDGQYEDGPFGWLAAQEVQRQQRKRRSDCSQAGGGGMLASTRCLDQSGMEILDPLSAEISAATIASLLQSDVRMAISNAFGDTAADGPLALIDWCKGCVQGSDGGLCAESTNTEVNSTVTVVGESMTPSQSGGVLKGADIDDIRRNSSSSRAVDSSSLSDQTDPSQRRGLSDDSGFSHADALGYNESSILAIPTPSLLVGYQEDWLKTSSSALHLWEKAPLEPYAPSKQVNYHVICLASEPLVTATADFFQQLSSVYEVCRLGSHMPVGTAAGQSGSIASSSKQALSGFSLVDISGVSHSTARREYFTASNYSLAKAFVADMTANWNMAEYRKALKKACKALPISSGSSVSQREPEQGPCTVVYVVCPVSDPAGILQIMVDACTSLGSGITGADSQRHGPSTPGEDAMSSNILGFSIPRFALQLVTAETIFKNSGPQASSVDVLKEVALGVYNKVRRIPRRSQRTEGLQNAGAAGSRGQGGNIGNPSGIQSNASMPGLWKDCSGQRSSGNPTMATVNSSNNHNMWENSWKQSIQTDLGTASNEITEEKIRYMYEPAYILARSGAQAPARTLSCDATRDAVAVSSHRTSAAASSGPDVDSTATTERLDGDASSAAQQAADLYCCYTWSEDWNWLVSVWTDARGELLDTLLLPLTGIDTTRENCLRLLFDQILQQGLQLLNLAVEAGSCRSRGLNITRLGGFYVRECQEWHRVIILAGADEMRKWPVQIRHPDCYSSNSVGGTGSSSDIGLMTDRGLGLAGSGPTSPSPSSSSFGGRGKPSHYSKSGAEMSSGMNRLQNQATNQMAATEPNSGGFKWVHSISLVSVRVDQSLQIVSTTDGPPEGNSSSGPSWPAGSGSASSGVVSMGVNAVKTLALTGASYLVVPSHVNRPLSSSSLELLLETPYSEQSPLAQLLQSSGVAFPVSTAYAVSAGTSSTINDFAQKGMKEDWPSTMSVGLVAHYGTSSRLGTPVQDSAGVAMSKSFKSTVVESKEQALEVHRVLQAVASDLHALSWLNVGLTYVKRRSPLPFHCEVAQRSQRLLDFLDAEHRHGVTNMS
The following text describes a protein:
Function:
Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, MMS22L acts by binding ssDNA.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MFRDQENSFQLFLRLLAVQLRHPTASGELQGWKQIKGRFYSKFHQKRMQELTAIGLSNFITLFLTLALVADVNDVAGKMQDLLDLLNHGLMDFQRRTIIWKGVFALMQVHEHRQVDMAHLADRMAKSFNRTCSEFSQKGLDPSLRHQLWALLSIYVESSQDLCENSTLLHLSQAKLLASGYSQLLPVCRETELRTVFNFIQTLLAKHRSLYKRALRQQEEGVQQIQSTNMAVLQQQYRDIADALWTHIFPYVKKHSMTLTPPPTLADVAAGFTFLALDLPSTPDFTRQQQTFSSIFQYFGPEDSVCASICCRYLCHLIPNQSFMDQLSAECPAYQSGIVHAWFRCVMQTYGDDDQMQELTRLVLRLPEMEIILHSQHVTIEPSDNPETVAVKFIKAIGRHFNSLQSLQEKTEFRDQVLLYYGNVLRYMGPYLKNSGPAEALRVGYHMVGCMVKHCTKILYVQSNPRSLLPSLMDRLVLPRAIYNPEKTLHPAVMGVIRDHLHLFIQGLSKLSYKRDPFVQKALRDILQQYFHRFSVKSGSFTSGQAQANHPLLLALSETMSNSPSTEASLFRVHLLEGIRDMYITLRSGSLPNRVTETFSFILELLRRTQTSGQIARDTPVLFATVMEYQLLCDLPAIKKQVSEMLQFMMESCQQCPDVTPRSVLLPILRDFLGRNLRLHQSRTFRPFETLALLYKDLIADLIPVFTNAVLEVEQKRGVGADTQLRQAYTSLLNQLGQKGQEQLDALNTEQHDQIM
The following text describes a protein:
Function:
Serine/threonine protein kinase which acts as a downstream effector of the second messenger cGMP.
Subcellular Localization:
[Isoform 1]: Cell membrane; Lipid-anchor; [Isoform 2]: Cytoplasm.
Sequence:
MGACSSKAQHQTRDPEPREQQAAQEQKSTGPSGAPNDAPAPAEAERKMSGSSATAPKGEMPTASTGTPEQQQQQQQQQQQQQEQQQHPEHQQSEKQQQHGEEQQQERKPSQQQQNEEAAAPHKHGGERKVQKAIKQQEDTQAEDARLLGHLEKREKTPSDLSLIRDSLSTNLVCSSLNDAEVEALANAVEFFTFKKGDVVTKQGESGSYFFIVHSGEFEVIVNDKVVNKILTGQAFGEISLIHNSARTATIKTLSEDAALWGVQRQVFRETLKQLSSRNFAENRQFLASVKFFEMLTEAQKNVITNALVVQSFQPGQAIVKEGEKGDVLYILKSGKALVSIKNKEVRVLQRGEYFGERALLYDEPRSATITAEEPTVCVSIGRDLLDRVLGNLQHVLFRNIMLEALQQSKVFASFPTEQLSRLIGSVVVKDYPENYIILDRENRTRASASALFSAQGVRFFFVLEGEVSVFAYKDKSSSSSSSSSSSSSSSSAEGEMELHLIDTLKRGQAFGDEYVLSPNKPFAHCVKSNGPTKLALLTASALTATLGGQDIDETLDYNNKLAITKKMYIFRYLSEQQTQTLIKAFKTVRYTQGESIIREGEIGSRFFIIKLGEVVILKGEKRVRTLGRHDYFGERALLHDERRSATVAANSPEVDLWVVDKDVFLQIVKGPMLTHLEERIRMQDTKVEFKDLNVVRVVGRGTFGTVKLVQHIPTQMRYALKCVSRKSVVALNQQDHIRLEREIMAENDHPFIIRLVRTFRDKEFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHERNIAYRDLKPENILLDSQGYVKLIDFGCAKKMQGRAYTLVGTPHYMAPEVILGKGYTLTADTWAFGVCLYEFMCGPLPFGNDAEDQLEIFRDILAGKLIFPHYVTDQDAINLMKRLLCRLPEVRIGCSINGYKDIKEHAFFSDFDWDRLAGRDLSPPLLPKGEIYAEDAEEGGLDIEEDEGIELEDEYEWDKDF
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
MENGGEPSIKKSRLQKEPMAVKHERAETRESQGGEGALLAVEEAMQVPWVAAEVNPLFYLCFACQLPLRPPVHQCEGGHRVCGRCHGDRCTACDPPAAYSPFPFMDDALAAVRLPCCYRADGCGRKLMYHEAADHALQCAFAPCHCPGHGCSMWASPPALLDHITAAHSWPVTEVGYGSPFRIAVPAPWRGGGTHLLVERNDPRLFLVTLSDFGEATAVTVVCVREGTAAAAPRFRSTVWAEVASNTEEKLFRRQSTVPSSSSGGSLPGGGPPVCLLVPPDFGSESEDLFLGVRIDKL
The following text describes a protein:
Function:
Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase (Probable).
Sequence:
MHEVSLMEQTLAIAIAQAEDHGASQIHRLTLRVGQQSGVVADALRFAFEVVRQNTMAAEARLEIEEIPVTCRCQHCHENFQPEDWIYRCPHCDQISQTVMDGKQLELASLELS
The following text describes a protein:
Function:
Involved in neurogenesis. Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate.
Subcellular Localization:
Nucleus.
Sequence:
MGLSDIPANYMQGSHPHLTLHPQQQHHQNQQHLQHLQQMQQLHNAMPTPAQQAAQVLAMESNELLMSTKDKLSSKKKMHLLKKIKKRFGLVRRSPSSCPGPNNLPPLQFHSVHGDNIRISRDGTLARRFESFCRAITFSARPVRINERICVKFAEISNNWNGGIRFGFTSNDPVTLEGTLPKYACPDLTNRPGFWAKALHEQYCEKDNILYYYVNGAGDVIYGINNEEKGVILTGIDTRSLLWTVIDIYGNCTGIEFLDSRIYMYQQQPAAIPMATVPAQQQQMPQPAANASSALNSHHPHQQSRRSLPGHTAAIEHDLERHVMPSLQSLHLAGNGGSVASVEQAAIAHDLANGLPPLRYNANGRLIPVPFHNTKGRNVRLSQDRFVASRTESDFCQGYVFTARPIRIGEKLIVQVLKTEQMYVGALALGLTSCNPAMLQPNDLPNDSDFLLDRPEYWVVSKDIAAAPQRGDEIAFFVAPNGEVSISKNNGPAVVVMHVDQSLQLWAFLDVYGSTQSLRMFRQQLPNMVAYPSQPQVNVNASSSSACNAASTSRMLPMTESMSSLNAGATAKLLHHPSQLSVAQSTSTLASAGGVNGSRMISMPSNGDILQIQPNGGGTVLVVNLPPASSSHDINGQLAARPTATVTSSGVLAGACSSGTLISTTSSQYIEQPIANSTNNAANKWKDSLSDQQSTDSSAECTICYENPIDSVLYMCGHMCMCYDCAIEQWRGVGGGQCPLCRAVIRDVIRTYTT
The following text describes a protein:
Function:
Can hydrolyze phosphorylated Ser-, Thr- or Tyr-substrates in vitro. The natural substrate is unknown.
Miscellaneous:
MISCELLANEOUS: Neither magnesium nor calcium stimulates activity.
Sequence:
MMRPEEIYQRIEAKNWRHVWVVGDIHGCFSMLMKRLRECRFDPQQDLLVSVGDLIDRGPDSLGCLALLRESWMTAVRGNHEQMALDARASSQSTLWLMNGGDWFTRLTAEHAAQAEALFILCQRLPWILEVRCRHSTHVIAHADYPASTYQWQKKVDLHQVLWSRERLINKRGGISGADHFWFGHTPLRRRMDFANVHYIDTGAVFGGQLTLARIQ
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MPHVAAPSRQALERERLHRHAQQPSSSLSHAAARRLSPLKLYLLAYNILSALLWGHLLVLTLSFLLAGPTAPRFVDHLRGSYDYHGLGWWTKWTQTLAVLEVVHAALGWVRSPVGTVASQVASRLWTVWGVVEAAPEITHGHPLFTTMLFAWSLTEVIRYSFYALSLLSISAPALNYLRYTTFIPLYPLGAASEAFLSFATLPALAPVVSRAVTNVMAQAPREIMKSKVGREVLWWCAKHGGGTAGAQQDWGWIEIVRAGLFLLWWPALYVLYTYMLKQRRKVLGKGKTVGGVSKAQ
The following text describes a protein:
Function:
Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (By similarity). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. Also functions downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Cell projection, axon.
Sequence:
MSSSGTPDLPVLLTDLKFQYTKIFINNEWHDSVSGKKFPVFNPATEEKLCEVEEGDKEDVNKAVAAARQAFQIGSPWRTMDASERGRLLYKLADLVERDRLILATMESMNGGKLFSNAYLMDLGGCLKTLRYCAGWADKIQGRTIPSDGNFFTYTRHEPVGVCGQILPWNFPLLMFLWKIAPALSCGNTVVVKPAEQTPLSALHVATLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPFIVFADADLETALEVTHQALFYHQGQCCVAASRLFVEESIYDEFVRRSVERAKKYVLGNPLTPGVSQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFIQPTVFSNVSDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTTYGLFAGSFTKDLDKAITVSAALQAGTVWVNCYGVVSAQCPFGGFKMSGNGREMGEYGFHEYTEVKTVTVKISQKNS
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 2300 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MWNPILLDTSSFSFQKHVSGVFLQVRNATKRAAGSRTSMKDSAGRRLGPKKYEGQDVSTGEIIMRQRGTKFYPGENVGIGKDHSIFALEPGVVRYYLDPFHPKRKFIGVALRRDLKLPSPHFEPTVRRFGRFELTNKRAAYKEENSISRKDYLAKPNILKQLEVRESKRKELQDKLSKVLRDELKLDIKDIELATSYLIRVRASLKNGYPIEDARFNSRYYLKEEERLKARRESWTNEKLSESLSKIDECSDLLNSSTSFNNKLELHQYISEQEKQALKAKLLEDLEKSQHLETKKDKNYIKALFKDACNFLTLSEEVHLRRKYLKSVFPETDSTVETKSGKKSIVSRRFDYTKNKVEVIARSRRAFLSKL