lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
Subcellular Localization:
Secreted.
Sequence:
MGVHECPAWLWLLLSLVSLPLGLPVPGAPPRLVCDSRVLERYLLEAKEAENVTMGCSESCSLNENITVPDTKVNFYAWKRIEVGQQAVEVWQGLALLSEAVLRGQAVLANSSQPFEPLQLHMDKAISGLRSITTLLRALGAQEAISLPDAASAAPLRTITADTFCKLFRVYSNFLRGKLKLYTGEACRRGDR
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Sequence:
MRKRIIIFGATGSIGTQTLEIIDKNKDKFELIGVASKGNVDKLKAIAEKFKVPYVALFDNKPFSLSYNAKTFYGKEGLEQLANLDSDLVIMSISGIEAVYPLKISIERGANIAIATKEIVVACGDLIKKWLKKSKSKLIPIDSEHSALFQLINSFRKKNIEKIILTASGGPFWNKSREEMEKTKLEEVLKHPTWKMGYKTTIDSANLVNKGLEVIEAHFFFNFDYNSIKVMIHPQSIVHGMIELVDGSIIAQMAYPDMRIPIQYALFYPQRPKIKWSPFDLKNQKLEFYDVDYDKFPALQLAYEVGKKGGVYPAIFAISDEVLVELFIKGIINFKDIVSFIKYALESWKEFKEIENLEQIEYIKNWIKNLIKQKVGYNL
The following text describes a protein:
Function:
DNA-binding transcriptional regulator that functions as a regulator of central sugar catabolic pathways.
Domain:
Contains an N-terminal DNA-binding winged helix-turn-helix domain and a C-terminal regulatory domain (or effector binding domain) resembling phosphoribosyltransferase (PRT) domain.
Sequence:
MKNVDDLIDDAAALADRGLSRGEIADELNVSRETASWLVERADTNASVAATDTDDSPRDVHVDWSTIGEAGARLSAIGIALADALRDHSHDVDLVVGIEKAGVPLATATANELGTDLATYTPRKHQWDEGDMADLGGSFSRNFASVEDRDCFVVDDTVTSGTTITETIQAVREAGGTPVACGVLADKQGLGDVDGTPIEALLQVIRVGSGDD
The following text describes a protein:
Function:
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type IV membrane protein. Note=During macropinocytosis highest levels are found in endosomes with lower levels observed in the lysosomes.
Sequence:
MSQTDILYACVSYKGVCLVEHKIANGNFIDLARRLITKIPPTSKKIYTSENHNFHYISENDLAFLCLCHEKLGVQIPSEFLSDIRQQFIRSYGQSFSQNSPTATYDPFIRVLEERMKYYSNPKSNKMNLVMDQVSEAKGALTDAIEKTIHRGEKIEIIVDKTERLQSESFVFKSNSVALKRKLWWQNKKLAIAIGLVVCILIAVITLALLKYFKVI
The following text describes a protein:
Function:
Controls formative cell division in meristems, including root tips and lateral root initiation zones of the pericycle, in response to CLE40 signal. Acts with CLE40p peptide as a ligand-receptor pair in a signal transduction pathway, coordinating movement of the root tip and organization of cell divisions in the root meristem. Required during embryogenesis and development, probably for the differentiation of protoderm and epidermal cells. Involved in the regulation of cellular organization during the development of sepal margins and ovule integument outgrowth and promotes giant cell formation. Can phosphorylate ALE2.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein. Note=Also localized into protein export bodies. Internalization may be involved in degradation of ACR4 for its rapid turn-over. In the epidermis, mostly expressed in the lateral and basal planes of cells.
Sequence:
MRMFETRAREWILLVKLVLFTSIWQLASALGSMSSIAISYGEGGSVFCGLKSDGSHLVVCYGSNSAILYGTPGHLQFIGLTGGDGFMCGLLMLSHQPYCWGNSAFIQMGVPQPMTKGAEYLEVSAGDYHLCGLRKPIVGRRKNSNIISSSLVDCWGYNMTRNFVFDKQLHSLSAGSEFNCALSSKDKSVFCWGDENSSQVISLIPKEKKFQKIAAGGYHVCGILDGLESRVLCWGKSLEFEEEVTGTSTEEKILDLPPKEPLLAVVGGKFYACGIKRYDHSAVCWGFFVNRSTPAPTGIGFYDLAAGNYFTCGVLTGTSMSPVCWGLGFPASIPLAVSPGLCIDTPCPPGTHELSNQENSPCKFTGSHICLPCSTSCPPGMYQKSVCTERSDQVCVYNCSSCSSHDCSSNCSSSATSGGKEKGKFWSLQLPIATAEIGFALFLVAVVSITAALYIRYRLRNCRCSENDTRSSKDSAFTKDNGKIRPDLDELQKRRRARVFTYEELEKAADGFKEESIVGKGSFSCVYKGVLRDGTTVAVKRAIMSSDKQKNSNEFRTELDLLSRLNHAHLLSLLGYCEECGERLLVYEFMAHGSLHNHLHGKNKALKEQLDWVKRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEEHNARVADFGLSLLGPVDSGSPLAELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVLLLEILSGRKAIDMHYEEGNIVEWAVPLIKAGDINALLDPVLKHPSEIEALKRIVSVACKCVRMRGKDRPSMDKVTTALERALAQLMGNPSSEQPILPTEVVLGSSRMHKKSWRIGSKRSGSENTEFRGGSWITFPSVTSSQRRKSSASEGDVAEEEDEGRKQQEALRSLEEEIGPASPGQSLFLHHNF
The following text describes a protein:
Function:
Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction. Also involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the control of actin-cytoskeleton organization.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Early endosome. Midbody.
Sequence:
MFPLRDTEMGASTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDITRGKHERLVVAAEHCENSLEDLLREGKPVSSSRILCIAYEVLQGLQYMNKHGMVHRALSPRNILLDRKGHVKLAKFGLYHMTAQGVDVDFPIGYPSYLAPEVIAQGMVKPSDHTQCEKPLPSGPKSDLWSLGIILFELCVGRKLFQTLEIAERLKFVITLDDIVTVLAEEHGCLDIIKDLSENVITLLKKCLTFQPSKRPTPEELMHDHLFSEVSLAYPPFHKPAGLFSSSPRCADLTLPEDISQLCKDEDNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPVCTLPNFVLEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSTLPHSNSSSELSAAANLPLIIRERDTEYQLNRIVLFDRLLKAYPYKKNQIWKEARVDIPPLLRGITWAALLGVEGAIQAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFRWTPKSATYRQYAQPPRHANESNGTRSSMSCFSVDYQEAPRGDLSRDSIKLDDLKAEVSPRISAEDLIDLCELTGPSHSKTPIKKTKSSKPKLLVVDIRNSEDFNRGHISGSINVPFASAFTAEGDLIQCPATATLQSFKGRVVVIVGNAVKNTAAFAAHLVKSKYPRVCILDGGINKIKPTGLLTVPSPQI
The following text describes a protein:
Function:
The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGNEGEVKVAVNGTSIEEVNFEKIDLKEALSILNTTPHGLSSAEADKRLAEYGPNRLPESKRIPLLVFLGYMWNPLSWAMEAAAIIAIALLDYADFALIVGLLFLNAVISYVEESSADNAIKALAGALAPKCKVIRDGTLQTMEAVNLVPGDVVVMKFGDIVAADVKLFSDDPQHPFDSHSEEVPMQIDQAALTGESLPAKKHTGDVAFSGSAIKAGERHAVVYATGINTFFGRAAALISGTHNVANLQIIMTKIGGVCLVTIGVWVVIELAVQFGHYGHGCTSGEEGCPTLTNMLVILVGGIPIAMPTVLSVTLALGAAKLAKEGAIVARMSAVEEMAGMDILCSDKTGTLTLNKLSIDMNTIYKCEPGITNDDVAKYGALSADVAGEEPIDMVLFNNYANAKDLAARYKKIKWVPFNPTDKFTAITLMDQETGRVFRLLKGSPQVVLGKAYNKDTLADNVNAKMVEFANRGFRSLGVAMAEGDGADGKHEWHMLALLPLFDPPRHDTKDTIEYCHGQGIEVKMVTGDHLLIGKETAKMLGMGTVMYPSEVLIKAKNGDKGALGDFRDVTHMVESCNGFAEVFPEHKYEIVAILQEADHVVGMTGDGVNDAPALKKADVGIAVAGATDAARGAADIVLTEAGLSAIKTAVLGARKIFQRMTTYSKYTVAMTFRICFTFGLLTVIYDWYFPTILIVIMAVFNDGAMIALAKDRVEPSRQPNAWNLKNIFLMGIVYGLYLTLSTWALYQTACKTSFFEDHFPIFSLDDRHITLQNWCTGYITNQLNLNPTASICTMPTYLAQFDSQAACIEEMGGEQIINQCMAEQRYIRGAMLRSLIYNHVSISGQALVLVVRNQGFSLMERAGSLTYIAFVLAQIGSTVISVFGFGGYVPPRHRFTDCQFCSYSDYTPVKFFPSKEVPMAGTESVYTASVLGCLGYVLVAWIWTGIWYVLLDPIKWALCWMLNEDGFRDMATMKHERRQELGRTSQQKAADVGVTGMTVPTASNPLGRASIQKPVTMVLDRASAALVPVHRTSDGLVRVSADPAKARDLARRSRLNEGMQRTSGGAHAAGHTGQKEITRA
The following text describes a protein:
Function:
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Sequence:
MPSIETQSTSPPPLRIPHREASAHKGNFGRVLLIGGSRGMAGSIALSSIAALHTGSGLVAAAVPDCILDCVAGFHPALMTIGLGDDGEKFADPAWQSLKDRLSAQAAIGCGPGMTTGSGGATIVEGLLAKKDLPLVLDADALNIIAQNDWLSDGRFERSKADAACVLTPHPGELQRLTGASAKDVDAQVEAAAELACRLGLTIVVKGGPSHVAYQNGDGGKQVWQNTTGNPGMATAGCGDVLTGIVTSLLGQGLSGPDAAKLGVWIHGRCGDEAAARWSHAGMTSLHALDALALVADEMTQPAD
The following text describes a protein:
Function:
Component of the box H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (Probable). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (Probable). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (Probable). Required for ribosome biogenesis (By similarity). H/ACA snoRNP complex-dependent ribosome biogenesis is important in female germline cell differentiation during oogenesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGFGKPRGGGGGGGRGFGGGGGGGGRGFGGGGGGRGGGGGRGGGGGFGRGGGGRGGGRGAFDTGPPERVIPLGNYVYSCQNDLVCKVDIQDVPYFNAPIFLENKEQVGKIDEIFGTVRDYSVSIKLSDNVYANSFKPNQKLFIDPGKLLPIARFLPKPPQPKGAKKAFTNNRGGGGGGGGFGGRGGGRGGGGRGGGGGRGGGGFRGGAGRNGGGGGGGGFNRGRGGGGGGGGGRGRW
The following text describes a protein:
Function:
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP.
Sequence:
MLPTKRADGAEDSGDAAAKKARVGESAAEAGSEAMVAGEPVGGGSNGNGVAEIDEDLHSRQLAVYGRETMRLLFASNVLVSGLNGLGAETAKNLALAGVKSVTLHDVGNVDMWDLSGNFFLSEDDIGKNRAAACVEKLQELNNAVLVSAVTEELTTEHLSKFQAVVFTNLSLDKAVEFNDCCRSHQPPIPFIKTEVCGLFGSVFCDFGPEFTVLDVDGEDPHTGIIASISNDNPAMVSCVDDERLEFQDGDLVVFTEVSGMTELNDGKPRKIVDARPFSFCIEEDTRNFGIYAKGGIVTQVKEPMILEFKSLRECIKEPGNFLLSDFSKYQRPPLLHFAFLALDNFRKKFGRFPVAGCDQDARKFVEFTASINEAAIDYKMDELDEKLLQHFASGSRAVLNPMAAMFGGIVGQEVVKACSGKFHPQYQFFYFDSLESLPTYALDPKDLKPLNSRYDAQISVFGSKLQKKMRDSNIFVVGSGALGCEFLKNFALMGVSCGRKGKLTITDDDVIEKSNLSRQFLFRDWNIGQAKSTVAATAASAINSSLHIDALQNRACPETEHVFNDAFWEGLDAVINALDNVNARMYMDMRCLYFQKPLLESGTLGPKCNTQMVIPHLTENYGASRDPPEKQAPMCTVHSFPHNIDHCLTWARSEFEGLLEKTPNEVNSFMSNPAEYAAAMRKAGDAQARELLERVRECLDKERCYKFEDCITWARLKFEDYFSNRVKQLTFTFPEDAATSTGAPFWSAPKRFPHPVQFSAVDSSHIQFILAASILRAVSFGIPIPDWAKNMGNLADIVSKVAVPEFEPKSGVKIETDEKATNLSSASVDDAAVIEDLLTKLEACAKKLPSGFQMKPIQFEKDDDTNFHMDLIAGLANMRARNYGIQEVDKLKAKFIAGRIIPAIATTTAMATGLVCLELYKVLAGDHPVEDYRNTFANLALPMFSMAEPVPPKEMKHQDLRWTVWDRWSIKGNITVAELLKWLSDKGLTAYSVSCGTSLLYNTMFPRHRDRLKRKMVDVAQEVAKVDVPAYRKHFDVVVACEDDDGNDIDIPLISIYFR
The following text describes a protein:
Function:
Metalloprotease.
Subcellular Localization:
Secreted.
Sequence:
MTRVVHIIGAAFLLSSYAYCGLSRFNEHDIEGGDSYKRVKREFERLGSKWLGGTINYYYADNNNSVKEKVKSAIAYIANHTCIKFNEDPTHWQRLKIFTSELSHCRSTIGAPGTRSGSAGELSMETGWCANIGSIVHEFSHSLGRYHEHTRPDRDNSLKVTSTDYEARPRPWGMTTMYGPFEHGSIMMYHSSNYGVGKMEPYDMEYKNTMGSRRVTFYDMYKINQYYGCGCSTQLECKNGGYTSPSDCSRCNCPKGFFGKLCNERRQQDSYELKATYGRWQTQTISFNYKPEPVSDGFYSTFVYITGEANSTIEITMEGLENVICTAGCTWNGVEIKSREDSRITSPVMCCKDEPLYKKVFKSLHNPTIIELYSKETAPSTATFKYRFMNDKIVFG
The following text describes a protein:
Function:
Alpha-toxin binds to the membrane of eukaryotic cells (particularly red blood cells, RBC) forming pores, resulting in hemolysis, with the release of low-molecular weight molecules leading to eventual osmotic RBC lysis. Human RBCs bind much less alpha-toxin than do rabbit RBCs. Heptamer oligomerization and pore formation is required for lytic activity.
Subcellular Localization:
Secreted. Note=Secreted as a monomer. After oligomerization and pore formation, the complex is translocated across the bilayer, probably via the Gly-rich domain of each strand.
Domain:
The mushroom-shaped heptamer is composed of a cap domain (comprising 7 beta sandwiches and the amino latches of each protomer), 7 rim regions whose protruding strands may interact with the membrane bilayer, and the stem domain (52 Angstroms in length, 26 Angstroms in diameter) which forms the transmembrane pore.
Sequence:
MKTRIVSSVTTTLLLGSILMNPVAGAADSDINIKTGTTDIGSNTTVKTGDLVTYDKENGMHKKVFYSFIDDKNHNKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNWGPYDRDSWNPVYGNQLFMKTRNGSMKAADNFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRDDYQLHWTSTNWKGTNTKDKWTDRSSERYKIDWEKEEMTN
The following text describes a protein:
Function:
Acts as a component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export; Component of the CUL4-RBX1-DDB1-DWA1/DWA2 E3 ubiquitin-protein ligase complex that acts as a negative regulator in abscisic acid (ABA) signaling. May function as the substrate recognition module within this complex leading to ABI5 degradation. Functionally redundant with DWA2.
Subcellular Localization:
Nucleus.
Sequence:
MYGDATNWNEDEYRESILKEREIETRTVFRTAWAPPARISNPDAFVVASSDGTLAFHSLNSLVSQSASFGYSKGQDVMVAEPERVVRAHEGPAYDVKFYGEDEDALLLSCGDDGRVRGWKWREFAESDVSLHLKENHLKPLLELINPQHKGPWGALSPMPEINAMSVDPQSGSVFTAAGDSCAYCWDVESGKIKMTFKGHSDYLHTVVSRSSASQILTGSEDGTARIWDCKTGKCVKVIGSQDKKSRLRVSSMALDGSESWLVCGQGKNLALWNLPASECVQTIPIPAHVQDVMFDEKQILTVGAEPLLRRFDLNGALLSQIHCAPCSVFSISLHPAGVVAVGGYGGIVDVISQFGSHLCTFRSSSL
The following text describes a protein:
Function:
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
Sequence:
MDNTLKHLAIIMDGNGRWAKLKNKARAYGHKKGVKTLKDITIWCANHKLECLTLYAFSTENWKRPKSEVDFLMKMLKKYLKDERSTYLNNNIRFRAIGDLEGFSKELRDTILQLENDTRHFKDFTQVLALNYGSKNELSRAFKSLLESPPSHINLLESLENEISNRLDTHDLPEVDLLLRTGGEMRLSNFLLWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MGYDLLRRPEFESSGDHRQQREEEGGEPRPENKKKRLVIVSVIALGMIVVSAVCAGLAIVLREGAADRVGGGGGGGVLIHRKPTRAISKTCSKARFPSLCVNSLLEFPGSLTASEQDLVHISFNMTLRHFSQALYTTASISYVQMDPRVRSAFDDCLELLEDSVDALSRSLSSVLPSQDGGYKGSSSQDVMTWLSAALTNHDTCTEGFEGVSGTVKDQVAAKLSDLAELVSNCLSIFAASGGDDFGGVPVQNRRLLASGDDLSGENVDEDKFPKWLGRKERVLLNTPVSAIQADIIVSKNGTVKTISEAIKKAQENSTRRIIIYVRAGRYEEKDLKVGRKKINLMFIGDGKGKTIISGGKSIFDNITTFHTAAFAATGAGFIARDMTFENWAGPAKHQAVALRVGADHAVVYRCNIIGYQDTLYVHSNRQFYRECDIYGTVDFIFGNAAVVFQNCSIYARKPMALQKNTITAQNRKDPNQNTGISIHACRILPASDLVASNGSFETYLGRPWKLYSRVVFMLSYMNNHVHPKGWLEWNTTFALDTLYYGEYMNYGPGAAIGQRIGWRGYRVITSEIEASKFTVQQFIYGSSWLPSTGVAFLAGLQV
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MLPDIISVPSTSVKCLSSEVLLPEDVGECEELEYKITKTQKPMMNRGACPSMCKVCRHPATGYHYDVPSCNGCKTFFRRSILDGRKYTCLKMKKCLSGNEPVGMCLFEKFSKEILFPDLTKRMCRSCRFEQCVEAGMNPSAIQADVKSSDGEILKNEIMRKQKGSVDGLSTPHVLLSFEDKVNEIIEKLTSMEVKIEPLYTEGLPPGYKDNRKLEDVINSPMILRYDEIPNLEYCPVIDESTGQIKSSGACYIHCCYLASIEYSKMFDFVNKIDAANKIILVKHATVMCADIMTSFFSYDRLKSDKLIHPNGLFAGPPRPRYGEVGAKHQAGMQRTLVTVLRNELNRVEYLLLKAIVLCNPAVSGLTETVQEVIGKEREQYVRTLLTYCLLNYGSVHGPSRFSALLAIMSVLESQQRNAKDFHLLAKATVLKDLVRYTRVSQLYEQIMES
The following text describes a protein:
Function:
Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MGVPKFFRWMSERYPSISQLIAENRIPEFDCLYLDMNGIIHNCTHKDSDDATFRMTEEQMFIAIFNYIEHLYGKIKPKQLFFMAVDGVAPRAKMNQQRARRFRTALDVENAREKAIREGKEMPKEEAFDSNSITPGTEFMQKLTLQLKYFIAKKISEDVDWQGTEIVLSGHEVPGEGEHKIMEYIRLKKAQPDYDPNRRHCLYGLDADLIMLGLLSHDPHFCLLREEVTFGRQSKAKSKELEHQNFYLMHLCIVREYLELEFQELKGDGVLGFPFDLERVIDDFILMAFFVGNDFLPNLPNLHINEGALALMFKVYKTILPKGGGYINEGGVINMSRLAILLDELSHVEYRFFESESSDSSWFKAKQMSKEDVMVKGKNKGKLVMTTAQQQIWKQVKSYVQKRGTEALDLSEKLPAADRKFAQDLAESLHLEWKTVQSDDGERHMQLSFPAKLGADDDEEDDDEEEESQLAIMRIVKQYDKAEVLDVTREQAQAEMDRKYEEKFQEWKDKYYDGKFEWDRKNETELTNLCENYVQGLQWVLYYYYRGVVSWPWYYQYHYSPMISDVIKGLKADVNFKLGQPFHPFEQLMGVLPDRSKKIVPTVYHDLMTNPASPIIDFYPRDFELDMNGKKMEWEAVVKIPFIDEKRLLDAMATKNNLLSDAEKARNEFGVSLKFTYDPDVDFTYPSSLVGIFPDIAHCHCIENIFDLPTIEGLDFYHGLMDGAKLGSASLAGFPSLNYLPYNATLGFHGVNVFQSDSRNESMVVTIEDCEVRTNVKTAQQKLGKRVFVGYPFLQEGKVVKVSDELFDYLPSEDASGQPISRAHGPREIDDFRKKAERIESTYSKRLGIIIGPVESLTHVEMLKGLKKMDDGATIKEYAVIPGQDTDYASQVVVDEVISEDQRFLERAALPVEEEFPVDDRIFFLGDFNYGRPGLVEGHADHKLQISLSTIKGKEVEFGRNIVHNAKNNSHYTPSFAVAKMLGLHPLVLSKITSSFQVSAVGQLRVNLGLNLKFEGKKLKVLGYSRRADNGWEFSNKAIELISTYMTKFPHFFAGIQRKPQGNEYEESDFPGASVKEIVAWLKTIESKNFEKVPLDAEQLDSDTVMAIEEAAQEALINGPQPQRTTLKAVPRGALLKPSDAEHRCGNQKFALGDRVVYVADSGRVPIATRGTVVGISRTPRTTLLDVLFDVTFMSGTTLGERCSPFRGSTVPIASVLNLTNKQLIAGSRAAAEKRPAPTTTPLTANGGYGFGRGQQYRESGPPPPLRGSFRGAVSGQRGNFVPRGGRGRGGFTNGNAHGNSGDNATPAVHSSMVIRDTTPVNTTGNANGTRGRGTAFAAARGGGSAAGSVAYNNVPPPAALDSRGRGRGRGGRGRGASRGRGGNPHPPQA
The following text describes a protein:
Function:
Metalloprotease which cleaves TGF-beta family ligands daw, Actbeta and myo in vitro. Cleavage of daw enhances its signaling activity. Cleaves dorsal-ventral patterning protein sog. Processes sog more efficiently than metalloprotease tld which also cleaves sog. Required for normal dorsal development. TLD may interact physically with DPP-C protein.
Miscellaneous:
MISCELLANEOUS: Mutations in TLD lead to a partial transformation of dorsal ectoderm into ventral ectoderm.
Sequence:
MKGMRLMPMKMKAKLVVLSVGALWMMMFFLVDYAEGRRLSQLPESECDFDFKEQPEDFFGILDSSLVPPKEPKDDIYQLKTTRQHSGRRRKQSHKSQNKAALRLPPPFLWTDDAVDVLQHSHSPTLNGQPIQRRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHGCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYDYLEITEEGYSMNTIHGRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFMAVDPPEDSVGEDFDAVTPFPGYLKSMYSSETGSDHLLPPSRLI
The following text describes a protein:
Function:
Non-vital for development.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MTSLRQKQINALKQMLNLNQPQSKLSASEPKWKVLVYDNVGQDIISVLISVKELRELGVTLFVQLHSDRDPIPEVPAVYFCAPTEENLGRIAQDFQKGVYDIYHLNFISAISRQKLEDLASAALQANCVANIHKVYDQYVNFISLDDDMFILKNQNSDALSYYAINRGDTKDTEMDEIMDKIVDCLFSVFVTLGTVPIIRSPKGNAAEMVARKLDKKLRENLADARNNLLHSDAQAGNFNFQRPLLIVLDRNVDMATPLHHTWTYQALAHDLLNLNLNRVVIEESVPSGGVRSKNRVCELDTKDKFWSTHKGSPFPTVAEAIQEELEQYKSSEEEVKKLKSSMGIDGESDIALSLVSDNTAKITSAVNSLPQLLEKKRLIDMHTTLATALLNGIKSRKLDNFFELEEKIMSKTQALEKTIYDLIVDPETGVPEDKIRLFIIFYICSPHMSESELKRYETALSEAGCDLSPIHYIKRWKSYAKMASGSNQYEGAGTKTVNMFSKLVSHGSNFVMEGVKNLVIKRHNLPVTRIVDHLMEFKNSPEMDEYHYLDPKQLKVTEIPRNRSPFQDAIVFIVGGGNYIEYQNLVDYARQKTAAGSTKRITYGSSTLANAQQFLKQLSLLGQEIV
The following text describes a protein:
Function:
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDEVCAAPAPKKMVAKSLVLNTFRKASVKEVVELKKPWKKVLWRKQDYPDNFIDESFLNGLQRNVNIQVTDFWSLVADSLPVSQHLSSVVIFASVFVSIYRNQLSCALVGFVSNVSAVAAFILWDFVLRKPCNNRTFPNYMGIVKSCILIVLTLAGLSPILMSLTKSTSPDSVWAIAVWLFLANVFFHEYTTETIRPHVRLHNSLSTNAALSASVVLASRLEKSINVFFFILFAVHWFALFPIFRKYIHVFSFYADMLMTLVLIISAYIALNAVASVVIAFVFLSLIFFISFICPIWFIKLQRFKNEIHGPWDIALPKLGPSKG
The following text describes a protein:
Function:
Involved in fertilization ability of sperm.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome.
Sequence:
MMPMKFLVLLVALLLWPSSLPAYRRVTVTPDEEQNLNHYVQVLQNLILSVPTKEPGRQKKSKSPNNANFIGPRVSRVKELKYTHDVGPGDNDVLINPVSEETTTFPTRGFTLEIDKKKRTKSTAFWSIKPSNVSVVLHAKEPFIEKDEPEPEPEPEPEPEPVEHRTGAPTQVPSVTEPSQDVTSLSGSTDLGTATEEEDVPQLSGDNEMDYLESHDMYNEDVLKRIADINSQLHHVPLPESYKPEYRADIRASKEHLKRSLALAIAAEHKLEKMYKSQMLPQGRSSGGVYDIITVINMLYNSRYKLSEYLDIKYVPLEMRGKATVVVHTLKRILCVGHGEETHNLLKQLLNNNIRILHILDTHDKDDSS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Sequence:
MLTCKAFAKINWAISVLKKRDDGYHDIISLMQAIDLHDTLIFKSSQKIEIETDLLIKKENNLVYKAIKALQNYTGIKKGVTVILKKEIPLGAGLGGGSSDAATTLKALNELWQLNLDIKTLHEIGASIGSDIPFFFYLPICIVEGRGDVVKPLKISKSYTLLLVKPDFSISTEWAYKTLDLKTELTTEYEKINNNIWQLYNHLYSGDVDNFYLWNDLEKSVLEKYPEIDKIKRKLIEAGAKSSLLSGSGSTVFGLFNNKTDAQKALKFFEGYWCRVVQTLVEPLK
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Seems to be involved in the sensing of bitter taste since it is expressed in neurons that mediate sensitivity to bitter compounds which are also avoidance-type taste neurons.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFRPSGSGYRQKWTGLTLKGALYGSWILGVFPFAYDSWTRTLRRSKWLIAYGFVLNAAFILLVVTNDTESETPLRMEVFHRNALAEQINGIHDIQSLSMVSIMLLRSFWKSGDIERTLNELEDLQHRYFRNYSLEECISFDRFVLYKGFSVVLELVSMLVLELGMSPNYSAQFFIGLGSLCLMLLAVLLGASHFHLAVVFVYRYVWIVNRELLKLVNKMAIGETVESERMDLLLYLYHRLLDLGQRLASIYDYQMVMVMVSFLIANVLGIYFFIIYSISLNKSLDFKILVFVQALVINMLDFWLNVEICELAERTGRQTSTILKLFNDIENIDEKLERSITDFALFCSHRRLRFHHCGLFYVNYEMGFRMAITSFLYLLFLIQFDYWNL
The following text describes a protein:
Function:
Component of the viral DNA-dependent RNA polymerase which is composed of four equimolar subunits of LEF-4, LEF-8, LEF-9, and p47. Plays an essential role in late and very late gene expression.
Sequence:
MTDVVQDFNELYDRIENKYKLKYTFDCATNSNERMLFCAIQERKSYLCCALNEQLSCVMHKCVPVIFGTRLDKQFRETDDVDANNNINGTFMLDGRFLSFPNIMMNNNVLVHNFYDKLYAKHCKRMFLYGNVDQEKHINRAIQLVYDKQDDVLFARDVYASDYVVTEDLNSVLETYLANSGKWKPLDFLFEYNTLHKQQLVEHIKIIMNHDINYSIDSLANKIVYKHAYLIELLLTSTILQNYQRVLDKTADDDAYTVANKRRKIQSVLYNKESKKIVDCIVNGRLIYCVSKTFSKQRKVFPNQQDNSSNNNIEISLPVLKYRVGNEVARITNDSMRQKMLKQKKDFVKFIGSFFHGEMTVAGKKFFLCRNACLPNVDYEMVAQKFQYLLKHNLVAFVDDLNDVQDDSLLIAFNDRPTNLKCLKSNTSFIVYTMKRNMAPIELKITDRILYVNHHEGMICIKKKLRVNNEADINVLLTPYEYHYKHSIYYNPIIQCTIVENDDVKSLMSKLEQYYYRNFIHLFHTTPVPKLIVSLTNLKNAMPVFEYKEENCVSGLPNGYSVAVNKSILLNNKMFKLWTLVRDNKLMTAEDPYIPHIALPICLYNNKVNKLKGKLVVGPKQSCLVKFTNSSDKNYVALDDGLVLYMAGVLVSNAKINWVYDGRRYKIETCTNGNFNVYKVYVYFRQIKNQKIEKLDASMVVNGDNVMLKIVIVTSTNDLEGIKICGIHGQKGVFNRSEDLTEWMAEDGTHAQICLSPVSFLSRQSNFDKIERKYVVRGGNHDDPHAKRYPIFNIPYMLFNNTPDNIFKEFIKTSHTGHEKVEGTRFDQWTKNQSFVGNRMSESLHWMRGGSNLPQNCGEFNVVSSLLMCNNTIMKN
The following text describes a protein:
Function:
Catalyzes the second step in the formation of ornithine lipids, which are phosphorus-free membrane lipids. Uses acyl-acyl carrier protein (acyl-AcpP) as an acyl donor and converts lyso-ornithine lipid (LOL) into ornithine lipid (OL).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MARLRLLLRSARLLGLVALGLGLAAWVSLRERLPGADVTPLRQRLTRWWLARLCAALPFEVRVSGEAPRQPMLWVANHVSWTDIPLLGALAPLTFLSKAEVRAWPLAGWLAEKAGTLFIRRGSGDSRLINQRLAEQLHRGRNLLIFPEGTTTNGESLRTFHGRLMASALEAGVAVQPVAISYRRDGVPDAQAPFIGDDDLLSHLGRLLRGERGSVHIQLLEPIPSQGLDRAELARQAQQAVRLALFGTAAPTQTRRAA
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.
Subcellular Localization:
Cytoplasm.
Sequence:
MPNHGDFLLNTQQLSAMTPADIECAAQLLKQGQLVAIPTETVYGLAADATQPEAVKQIFSAKGRPANHPLIVHLGSAEQLSEWATDIAPEAYQLAEAFWPGPLTLLLPKAKQVSPVVTGGLESVGIRVPAHPVLLDILKTHRLAVAAPSANPYKKLSPTSAQQVLDGLNGRLAAVLDGGECQHGLESTIVDLTSKPFRVLRAGPITASELSAVLGQEVLQPQVHQVAVPGNVDSHYQPKTRLRVIDDLARELATQSDELRIALLNLSALQASEQRLLKPMPQEAKAYGQALYRSLAEVDKWGVDEIWLERPPQGEAWLAVHDRLRRAAS