lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling, probably acting through RAB5 and RAB11 activation. Also involved in endosome to trans-Golgi network retrograde transport (By similarity). In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation. Appears to be implicated in intercellular communication by negatively regulating the release of exosomes. The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved. Required for the maintenance of neurite morphology and synaptic transmission.
Subcellular Localization:
Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Late endosome membrane. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Efficient exit from the endoplasmic reticulum does not require TMEM30A, nor TMEM30B. Transiently expressed in the cell membrane.
Sequence:
MTDSIPLQPVRHKKRVDSRPRAGCCEWLRCCGGGEPRPRTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFSQFRYFFNFYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTIIREAVEEIRCYVRDKEMNSQVYSRLTSRGTVKVKSSNIQVGDLILVEKNQRVPADMIFLRTSEKNGSCFLRTDQLDGETDWKLRLPVACTQRLPTAADLLQIRSYVYAEEPNIDIHNFLGTFTREDSDPPISESLSIENTLWAGTVIASGTVVGVVLYTGRELRSVMNTSDPRSKIGLFDLEVNCLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMVFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTVTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTDQAEAEKQFEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQVLNLTILQVFPFTYESKRMGIIVRDESTGEITFYMKGADVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLTEEQYQDFEARYVQAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCALVISGDSLEVCLKYYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYPELYKDLLKGRPLSYKTFLIWVLISIYQGSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVFLHEFIDVYFIATLSFLWKVSVITLVSCLPLYVLKYLRRRFSPPSYSKLTS
The following text describes a protein:
Function:
Involved in the regulation of calcium ion homeostasis. Binds to the calcineurin-dependent response element. Transcriptionally regulates PMC1, PMR1, PMR2A and FKS2.
Miscellaneous:
MISCELLANEOUS: Present with 1160 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSFSNGNMASYMTSSNGEEQSINNKNDIDDNSAYRRNNFRNSSNSGSHTFQLSDLDLDVDMRMDSANSSEKISKNLSSGIPDSFDSNVNSLLSPSSGSYSADLNYQSLYKPDLPQQQLQQQQLQQQQQQQQQQQQQQQKQTPTLKVEQSDTFQWDDILTPADNQHRPSLTNQFLSPRSNYDGTTRSSGIDSNYSDTESNYHTPYLYPQDLVSSPAMSHLTANNDDFDDLLSVASMNSNYLLPVNSHGYKHISNLDELDDLLSLTYSDNNLLSASNNSDFNNSNNGIINTADTQNSTIAINKSKVGTNQKMLLTIPTSSTPSPSTHAAPVTPIISIQEFNEGHFPVKNEDDGTLQLKVRDNESYSATNNNNLLRPDDNDYNNEALSDIDRSFEDIINGRKLKLKKSRRRSSQTSNNSFTSRRSSRSRSISPDEKAKSISANREKLLEMADLLPSSENDNNRERYDNDSKTSYNTINSSNFNEDNNNNNLLTSKPKIESGIVNIKNELDDTSKDLGILLDIDSLGQFEQKVGFKNDDNHENNDNGTFSVKKNDNLEKLDSVTNNRKNPANFACDVCGKKFTRPYNLKSHLRTHTNERPFICSICGKAFARQHDRKRHEDLHTGKKRYVCGGKLKDGKPWGCGKKFARSDALGRHFKTESGRRCITPLYEEARQEKSGQES
The following text describes a protein:
Function:
Negatively regulates NLRP3-driven inflammation. Promotes NLRP3 degradation through the chaperone-mediated autophagy (CMA) pathway, hence attenuating inflammasome activation and IL1B secretion. Acts by recruiting palmitoyltransferase ZDHHC12 to NLRP3, facilitating NLRP3 palmitoylation and subsequent degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MLTGVTDGIFCCLLGTPPNAVGPLESVESSDGYTFVEVKPGRVLRVKHAGPAPASAAPPPLSASSDAAQGDLSGLVRCQRRITVYRNGRLLVENLGRAPRADLLHGQNGSGEPPAALEMELADPAGSDGRSAPGSGSGSGSGSGSGGRRRRARRPKRTIHIDCEKRITSCKGAQADVVLFFIHGVGGSLAIWKEQLDFFVRLGYEVVAPDLAGHGASSAPQVAAAYTFYALAEDMRAIFKRYAKKRNVLIGHSYGVSFCTFLAHEYPDLVHKVIMINGGGPTALEPSFCSIFNMPTCVLHCLSPCLAWSFLKAGFARQGAKEKQLLKEGNAFNVSSFVLRAMMSGQYWPEGDEVYHAELTVPVLLVHGMHDKFVPVEEDQRMAEILLLAFLKLIDEGSHMVMLECPETVNTLLHEFLLWEPEPSPKALPEPLPAPPEDKK
The following text describes a protein:
Function:
Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro).
Subcellular Localization:
Secreted. Lysosome.
Sequence:
MRTLFNLLWLALACSPVHTTLSKSDAKKAASKTLLEKSQFSDKPVQDRGLVVTDLKAESVVLEHRSYCSAKARDRHFAGDVLGYVTPWNSHGYDVTKVFGSKFTQISPVWLQLKRRGREMFEVTGLHDVDQGWMRAVRKHAKGLHIVPRLLFEDWTYDDFRNVLDSEDEIEELSKTVVQVAKNQHFDGFVVEVWNQLLSQKRVGLIHMLTHLAEALHQARLLALLVIPPAITPGTDQLGMFTHKEFEQLAPVLDGFSLMTYDYSTAHQPGPNAPLSWVRACVQVLDPKSKWRSKILLGLNFYGMDYATSKDAREPVVGARYIQTLKDHRPRMVWDSQASEHFFEYKKSRSGRHVVFYPTLKSLQVRLELARELGVGVSIWELGQGLDYFYDLL
The following text describes a protein:
Function:
Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate.
Sequence:
MATDSQQRCPKIMVFRPTWDEFKDFSQYIQHMESKGAHKAGLAKVIPPPEWVPRKSGYAIDTLDVTIPAPICQVVTGKQGLYQQINIQKKSMTVQQYCELANSERYATPRHFDYEDLERKYWKNITYVAPIYGADVSGSLTDDTVNEWNINRLGTILDYVNEDYGISIEGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGAPKTWYSIPPEHGRRLERLANGFFPSSYKTCQAFLRHKMTLISPQILKQYSIPYNKITQEAGEIMITFPYGYHAGFNHGFNCAESTNFACERWIEYGKRASQCTCSKDMVKISMDTFVKRFQADRYEMWLKGEDIGPHPEEPNKQVAAPLPLPQDILCNKNNDSLPAGLIEGQLKKAKKAGRMMNYSQDYSMVDFPAELQLQLMEEDDMGYVNGEFPPDEQQLEVLEDIWLKAGEIEAEDASICDAGYRVTNRRKFLAKKRKPKEPRPRGRPPKKRTKDGEEEPESNELTGIYAPCNSQSKKVCGQIVAPVDTSELVKSLVAQETNKLLHHKKHKHKHKKCKHHQKTATQTSPDTANSEVKKEIDDIIRKAHEEHEQTIMQQEEKPPVKPSLLSELKAYRKVKDPTDQFRMEPKVQTIHTSKGTITVLESRPVVPPPPETKPPERKSLYEDAFLNFLTAKTDKPVPDLAGGSMPNLSEPEPVLIERSEQMPKLEPVPVEEAPTVQVNPNPVPPTYYQRKPNLIWSNHKYYTVNHCTTTTYLNNDRFYPMTNNPIVLLEKATPKTPDSDSGSDCSCESCSCSECDEQVENSSNSINVVPQNKKLNLEQLKQLTQRVLGVENGTKFYNDKIVALKKMLTMRRRGRPPKNNSLEKRNNNNTMTDFHSYNCKLLEKIAKLTPLEAKVKLVDVLNNFTNDVQNYLKAGLPLANVSALSLDEPPPNDETSERFPVKLNEFVWAKHLNGRFYKAKIVDIKIVTYFCVYFPLDQSFCKDVELADLVGWDLKKVPIVGQKLRVRWKDGTICVAEFLGKNNSSIFTVMFEDESRLELHRDSIVAASESISKKIASLK
The following text describes a protein:
Function:
This protein binds directly to 23S ribosomal RNA.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASASTTWSMSCLKSALPSIQPISSSSLRFSCGPSPSRLRICKPKSSSRLLHSFVGLAPLHPLLSLSSQDSTSFEHSFTVIDNGGRVFAMRHGRKVPKLNRPPDQRRALLRGLTTQLLKHGRIKTTKARARAVRKYVDKMITMAKDGSLHKRRQALGFIYEKQIVHALFAEVPDRYGERNGGYTRIIRTLPRRGDNAPMAYIELV
The following text describes a protein:
Function:
Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing. Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver. Also involved in the sympathetic neuronal development. Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKRGSRSQSQLLGSLTKKQKKHLRDFGEEHPFYDRVSRKEAKPQTCQLSESSDTSSSESEAESEPEQVSGYHRLLATLKNVSKEEEEEEEAEEDSVMDETEMNLEDGDSDISEEEDMAAESTDMQSSVASPADPEGKDGHGPPGTSEESPEEFTDAKHESLFSLETNFLEEESGGDSSPKASQDPFVQHVNTKLKEKEIQAVATNPKTTHQLKWPILGQVVFSSKFQKLETFKPPKDIDLKSVHLQKPLESTWIKTNSQFLSGPQKSNSPFTPLQKELFLIMNSYRDLFYPERTALKNGEEIRHVYCLHVINHVLKANAQVLGNNSRRRSQKLGVGDDDDFRDQGLTRPKVLIVVPFREAALRVVQLFISLLEGDSKKKIIVSNKKRFNGEYGSDPEERPPNLKRPEDYEAVFVGNIDDHFRIGVAILQRSIRLYAPFYSSDILIASPLGLRTIIGGEGEKKRDFDFLSSIELLIIDQADIYLMQNWEHVLHLMNHMNLLPLDSHGVDFSRVRMWSLNNWSKYYRQTLLFGALQDAQINSVFNKYCVNVQGQVAVRSVPMTGSISRVLVQLPHVFQRMQVESLASVIDARFNFFVNKILPQYRDAVMSHTLIYVPSYFDFVRLRNYFKKEELNFAHICEYTQKSGVSRARHFFLQGEKQFLLLTERFHFYKRYTIKGIRNLIFYELPTYPHFYSEVCNMLRATSRGEEAAWTCTVLYSKYDAQRLAAVVGVERAAQMLQSKKNVHLFITGER
The following text describes a protein:
Function:
May be involved in environmental stress response.
Sequence:
MEDPILCANGCGFFGTTATRNLCSKCYRDFLKEEEESTKTKVMSMKKAMGPRVESTSSLDDVATSMAQLSLSLDNTKKTSNGDPSTKMKSEQCEMCKKKMGIIGFKCRCGSMFCGKHRLPEKHECNFDYKAMGREILRKQNPSLKPEKLPGSNTPKEKEKNSESSANKRKPATRNLCSKCYGDYLKEEGESAKAKAMSMEKAMGPRVESTSSLDYVVTSMAQLSLSSENTNKVINGDLL
The following text describes a protein:
Function:
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.
Sequence:
MEEHYYVSIDIGSSSVKTIVGEKFHNGINVIGTGQTYTSGIKNGLIDDFDIARQAIKDTIKKASIASGVDIKEVFLKLPIIGTEVYDESNEIDFYEDTEINGSHIEKVLEGIREKNDVQETEVINVFPIRFIVDKENEVSDPKELIARHSLKVEAGVIAIQKSILINMIKCVEACGVDVLDVYSDAYNYGSILTATEKELGACVIDIGEDVTQVAFYERGELVDADSIEMAGRDITDDIAQGLNTSYETAEKVKHQYGHAFYDSASDQDIFTVEQVDSDETVQYTQKDLSDFIEARVEEIFFEVFDVLQDLGLTKVNGGFIVTGGSANLLGVKELLSDMVSEKVRIHTPSQMGIRKPEFSSAISTISSSIAFDELLDYVTINYHDNEETEEDVIDVKDKDNESKLGGFDWFKRKTNKKDTHENEVESTDEEIYQSEDNHQEHKQNHEHVQDKDKDKEESKFKKLMKSLFE
The following text describes a protein:
Function:
Seems to be required for the assembly of the photosystem I complex.
Subcellular Localization:
Plastid membrane; Peripheral membrane protein. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Sequence:
MSRSGINGNFIDKTFSIVANILLRIIPTTSGEKEAFTYYRDGMSAQSEGNYAEALQNYYEAMRLEIDPYDRSYILYNIGLIHTSNGEHTKALEYYFRALERNPFLPQAFNNMAVICHYRGEQAVQQGYSEIAEAWFDQAAEYWKQAIALTPGNYIEAQNWLKITRRFE
The following text describes a protein:
Function:
Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.
Subcellular Localization:
Cell junction, adherens junction. Cell membrane; Peripheral membrane protein. Cytoplasm. Photoreceptor inner segment.
Sequence:
MLSFFRRTLGRRSMRRHAEKERLREAQRATTHIPAAGDTRSIVTCRVSLLDGSDVSVDLPKKAEGQELFDQIMYHLDLIEKDYFGLQFMDSAQVPHWLDNTKSIKKQVKIGPPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLECPFDTAVQLAAYSLQGELGDFDPTEHTPDLVSEFRFIPTQSEEFEFAVLAKWKDFRGQTPAEAETNYLNKAKWLEMYGVDMHIVKARDGNDYQLGLTPTGVLVFEGETKIGLFFWPKITRLDFKKSKLTLVVVEDDEQGKEQEHTFVFKMDHPKACKHLWKCAVEHHAFFRLRSPTQKNSSRSGFIRLGSRFRYSGKTEYQTTKSSKPRRSSSFERRPSKRYSRRTLQMRGQAQRPDFTRSQRDQPGQTNGSQQAWPPNPSVSPSGAALLEIQNLTRSPGAGQGDRCFVGLANSKDLLESSLDDVMTVSQGPAPLLDEVTVAFANPDETALPPSKPAPGTEDATVKRNNLEADTVTAHPIWALNINVNTQDQTVKLPEKLLNNSVEAGGPPVWLTTDIKSNILKAQVEAGHKITREDLELDDKNTTQEESSARSGAVKVNNILSSPLNREPSPFWDSQDPTANVFIKNVLSSETSGREFPEIPPVQTPPEEVPDVKSPTEDLDNLIASLTENLIDLTDIPPKVPSYTSVTPRWLVPQSSVVSNGLLGGEMATGSAPERLPAPSDSPDTATPAGGASTGDPGGLPRPKCLLTTEL
The following text describes a protein:
Function:
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
Sequence:
MSQTSAHPTCLAVHELNADLDTPVTAYLKAAQGETVSFLLESVEAGEKLGRYSFIGVGEQGTFRACAGRVQSSGQFGDFDGEEADPLARLYRVTTRPLDVPAGLPALVGGAVGYAAYDIIRAYEKLPDANPDELKLPDALFVAPRGLVIFDHLKHRLVVVAAAEEQAQADAEVERLLTRLRGPLPEVPGQTPTAAPEFRSNFTPAEYMEAVRRGKEYVHAGDIFQFVPSQRFSAELGDLHPFALYRALRRVNPSPYLGYLALGEVTLVASSPESLLRSDGVSVVTRPIAGTRKRGATEAEDDALAAELLADEKERAEHLMLVDLGRNDIGKVSAYGTVKVENAFSIERYSHVMHIVSGVRGELREGQTPLHALASVLPMGTVSGAPKIRAMEIIDELEPVRRGPYGGCFGYVAFDGSLDMALTLRTMVIANGKVHIQAGAGVVADSVPELEEQETRNKAAALMRAVELAAGGL
The following text describes a protein:
Function:
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MADLANEEKPAIAPPVFVFQKDKGQKSSAEQKGLSDSGEAPQGEAESPHHGMGHPESAGEHALELPTHASASACASPLPASEARPTSIQQELAGRSADGSSPEDGEDSDREDGNYCPPVKRERTSSLTQFPPSQSVSKNNVFMPSTFCEPSTGNSDSEPEEKSSGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAPQPKALPQTVPNSGTNGVNVPSDCLGAAPSESINNSALKSSSDSADKLGHENAETTDLPNAGHPSSETPSATNYFLQYISSSLENSTSSSDTSSNKFVFGQNMSERVLSPPKSSEASIDSSKDNTAAESGSESSSLEATPEKANNVSESLAESAAAYTKATARKCLLEKVEVITGEEAESNVLQIQCKLFVFDKTSQSWVERGRGLLRLNDMASTDDGTLQSRLVMRTQGSLRLILNTKLWAQMQIDKASEKSIRITAMDTEDQGVKVFLISASSKDTGQLYAALHHRILALRSRIEQEQETKTTAPEPEVTQSNEEDSDDDVLAPSASTGGEALTPL
The following text describes a protein:
Function:
Suppressor of apoptosis (By similarity). Modulates unfolded protein response signaling. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MADTANYINDRFQTFMNGLGDRYEPYVREHLSKVYMVLGSTAAATAMGAMLQMRDFLDLGVLAAVATLVLVLGLHFYKDDGKNYYTRLGMLYAFGFCSGQTLGPLLGYICSINPAIILSALTGTFVTFISLSLSALLAEQGKYLYLGGMLVSVINTMALLSLFNMVFKSYFVQVTQLYVGVFVMAAFIVYDTQNIVEKCRNGNRDVVQHALDLFFDVLSMFRRLLIILTQKEERKQNERRQNKTK
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MGSRLSQPFESYITAPPGTAAAPAKPAPPATPGAPTSPAEHRLLKTCWSCRVLSGLGLMGAGGYVYWVARKPMKMGYPPSPWTITQMVIGLSENQGIATWGIVVMADPKGKAYRVV
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Regulates the activity of daf-16 and is thereby involved in regulating aging and stress resistance. Regulates nsy-1 activity and thereby attenuates the activation of sek-1 and pmk-1, two components of the p38 pathway, which results in susceptibility to pathogenic bacterial infection. Acts together with rege-1 to repress the expression of the transcription factor ets-4 by binding to the conserved ADE (alternate decay element) and RCE (REGE-1 cleavage element) stem loop structure in its 3'UTR, which probably controls the expression of lipid metabolism genes.
Sequence:
MAPTGQGGQWQEVLCCSICNRHFNETFLPVSLICGHVICRKCAEKPENQTKPCPHDDWKTTHSPSEYPNNVALLSVIFPRKQCMTLSGAVSEAEKRVDQLSIQIAKFFREADSERGGTVSSREISRTLQRKVLALLCYQWREVDGRLKTLKMCRGISERVMIEIILSIQSNTHVSSQLWSAVRARGCQFLGPAMQDDVLRLILMTLETGECIARKNLVMYVVQTLASDYPQVSKTCVGHVVQLLYRASCFNVLKRDGESSLMQLKEEFRTYESLRREHDSQIVQIAFESGLRIGPDQWSALLYADQSHRSHMQSIIDKLQSKNSYQQGVEELRALAGSQTSMLVPAYRYFLTQVIPCLEFFAGIEHEDTSMRMIGDALHQIRILLKLHCSQDDLRKMPKEERRGVILQAEVPGGMGGGPGGSGGAEAGRIGGLHPLYSQIDETGRSISRTNPKDNSHNSPQTPPKQPRQKRYQMGIPPNRMGYSSDAPPFIPSHQQQPPPQFFNSQHLPQRFRGGRQRGAPPPPPPQPMPMLIGYDMPGAPMMQATEVLTADGQMVNGTPQRVVIMQSPTHLPGGPVVMIPQQQMVPPPQSMTPVGGPMGPMGPMTPSIPVQVPPNTMWTATSPTGSVIYPAASPPGQPPHTIWIQSTDGNMFPMFDRGSGGMVWGPGTMLRESGADAEQLLAKRYEILKRLQPSEDDDDPEDGGIGHVSYTVASSVLDDRMDHHPLTMIPVPTIDLPAIPISFANMPTEETMTMIGEMVQNRPRAPSLTAPSSNQPMNVNASASATVQAECGTMSVMDSICQPISTSAIHNSATIPQPVIPMVQVPVQVPIVPAENFNPNVPPPPPPPQGQPMLVDSAIGLLTPIRPILVAHPQNVVSNSLDKIVDVKERISEAQGNASEAENAHLRMELRMAESQMAHLDPYTKNNCLLRALQQVDMELQQLHLNPTVEG
The following text describes a protein:
Function:
Orphan nuclear receptor that binds DNA containing an extended core motif half-site sequence 5'-ANGTCA-3'. Required for locomotion, neuron axon pathfinding, and regulation of expression of some peptide neurotransmitter precursors and of NMDA glutamate receptor genes. Involved in specifying interneuron identity, in concert with paired-like homeodomain unc-42. Plays a role in recognition of the PVPR and PVQL axons by the AVKR and HSNL growth cones.
Subcellular Localization:
Nucleus. Cell projection, axon. Cytoplasm.
Domain:
Putative ligand binding domain (NR LBD) may be dispensable for import into nuclei and in the development of neurons that control movement.
Sequence:
MSDEDEPLNFSTSKATEESKEGILGVRSIFNTPLLFPPPMFNAGVISPHIAAALAMSFNQQRMNASVSPPLDHTTISVNSFPSMGSVKTDSPPTASSPTLCCAVCGDVSSGKHYGILACNGCSGFFKRSVRRRLIYRCQAGTGNCVVDKAHRNQCQACRLKKCLNKGMNKDAVQNERQPRNTATIRPALDMDPQNFFREYAGAVSAIMGHSNMMKREDSPSSASDGKTEDEKKDSLQETTMSQLESVLQWAQQFRLFTVLTNSEKRQIILTQWPRLLCISLCEQAEDVSFDDHLTSLMLKFRRLDVSPAEFNCLKAITIFMKRELSLWRAGWDNRASIITVYPAGERGARLVAAALLLAEHSVMGFGNCVIPLALVFSTKSRYVIQRHAINSLPACVPGGTSAHPVLRCSMGSRREKVI
The following text describes a protein:
Function:
Promotes transcriptional elongation by Su(Tpl)/ELL. Essential for development.
Subcellular Localization:
Nucleus.
Sequence:
MDNRLNIGSEVRELKLGSTFSNAGPSNQFHTIKYDFKPASVDVNKPAVLEISANKQVTVTVPHLDGSGVPNTVFKGNQRDYSRKDCVLILNRATGEITLEQLNSSIVVKKTRIENKAPNPPPPTLPTIKVENNTARQSSKTKITTGVRKNAPISFMPKHSPLQGSPSYPHRSPQSAPAWNANNTQQTLPSIPMIGLDDGLDFGTVAPPPPSSSSSSSSASANASSGASMNNHLNNNLGGNSNSNHGSSSNNHHQHQQQQQQHHNQHSNNSSSSSSSSSSSSSSNVGNNHSGSNSGGYLNHGSTQNNNSSNNNNNNHHGSSSGNNHHHHSNHLSVPSYGGQGGGRNHLHSEPSLPPSVEVSLPPDRELLAPPVALTGIGVGATSDPEMMTSSESDGSDDSDSSSSDQESDSSTEDNNDSPVKESIFDPRPDPTVAVTAAAVDLSKDLCLSSNSDSDD
The following text describes a protein:
Function:
Important for bud site selection. Seems to be a regulatory subunit of the BUD14-GLC7 type-I phosphatase complex. The BUD14-GLC7 complex is necessary to regulate microtubule dynamics at the cortex and may function as a specific activator of the dynein complex.
Miscellaneous:
MISCELLANEOUS: Present with 538 molecules/cell in log phase SD medium.
Sequence:
MSNKEEHVDETSASGVKEVSSIAARHDNGYAPSLITSTSGMDSFQSHALLNDPTLIEDYSDIINNRPTSGSKLTLGNEDSESMGGSVVVTPTSNKSSPFNSKLNILSNAAEKGHDVLRNRDDDKELEEENVEKHMHSNSKRDQRHYKENSSELPDSYDYSDSEFEDNLERRLQEIETDSVDSADKDEVHFSVNNTMNPDVDDFSDGLKYAISEDEDEEENYSDDDDFDRKFQDSGFQGEKDDLEEENDDYQPLSPPRELDPDKLYALYAFNGHDSSHCQLGQDEPCILLNDQDAYWWLVKRITDGKIGFAPAEILETFPERLARLNCWKNENMSSQSVASSDSKDDSISSGNKNQSDAESIIPTPALNGYGKGNKSVSFNDVVGYADRFIDDAIEDTSLDSNDDGGEGNGQSYDDDVDNDKETKVTHRDEYTEAKLNFGKFQDDDTSDVVSDVSFSTSLNTPLNVKKVRRQDNKNESEPKTSSSKDREDDYNANRYVGQEKSEPVDSDYDTDLKKVFEAPRMPFANGMAKSDSQNSLSTIGEFSPSSSEWTNESPSTPIVEESSSIPSSRAIKDISQYIHAKSKIEETTNVENTEGQIQASLGSSGGMANQTDAEQPKEELEKHHSTPEEEKQSTLSLHSSSEEDFYMDEQRAVSSASINSSLSGSRALSNTNMSDPASKPNSLVQHLYAPVFDRMDVLMKQLDEIIRK
The following text describes a protein:
Function:
Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA.
Subcellular Localization:
Nucleus.
Sequence:
MNHQRPPNYSAPPPPPQQRQNHYLPRGGHTGIPPPGEIASGHSNAGFTMPNFNFPPPSLPPAMTRPPPPAPYYARERPERSHSPNTSSYHSSSQQHAYKRHPPPYKGTGGSQYPPQGRRYGSPSNNPVPSNTSGGTGYKHPGHSYSSAGHKTASYTRPSAPSRYAPSGRSHSVPSNTDRLGRPPRTDRSASCRRDSDSNSSSSERASSRHSRFKVDTERAEILSKWCRNYCETSEDIARKLAEMANDEDRTLWVRSSPAELYYKRVSDKVVESTARLDALCTLFEEELIKRAERIRATQTPYNPPPRKRKMKMCRHKHDKCSSSSESSDEEMEFEDECSMEELTAKIKHPLRLHVDLWYNDPGEMNDGPLCRCSARSRRTGIRHGKYPGEEGFPKCIPNSNNADKLYHYRITISPPTNFLTKTPTIIKHDQHEFLFEGFSLLAHEPIGELPTCKVIRFNIEYTILYIEEQMPENFTIRELNLFDRYLFRELLELVDFTVQPSGSGEDSSCPCYHFLPRFVRDLPDNGKEVLAMSEVLRYLLDNSGPLVPPDMLKEMMDMSQNEWQDYVDYVKGMVVSNPGMKPCSVRVDQLDRNVGDVPEANAIDENGLVHPVIVHFGIRPPQLSYAGNPEYQKAWREYIKFRHLIANMSKPSFEDKRKLEAKENRLLEMRMQGRMKRNITIAVSAKAFHRTGIMCDMVQHAMLIPVLTGHLRFHRSLNVLERYIGYTFTNRYTLQLALTHPSYKENFGTNPDHARNSLTNCGIRQPEYGDRKIHYMNTRKRGINTLISIMSRFGKEHETDSNITHNERLEFLGDAVVEFITSIHLFHMFPDLEEGGLATYRAAIVQNQHLAVLAKKLHLEEFMLYAHGSDLCHELELRHALANCFEALMGALLLDGGIEVADRVFAYALFQEDDTLRGIWVNYPSHPLQEQEPLGDRHHIDSFEMLKTLTRFEDSIGVQFNHIRLLARAFTDRSIGFTNLTLGSNQRLEFLGDTVLQLICSEYLYRHFPEHHEGHLSLLRSSLVNNRTQAVVCDDLGMTQYAVYSNPKADLKTKDRADLLEAFLGALYVDKGLEYCEMFCHVCLFPRLQDFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPVYKVIECTGPTNTRVYSVAVYFRGKRLACADGHSIQQAEMNAAKQALENSKDLFPQLDHQRRVIAQSLKRQKVPRSAGGPGGRGGPGGGGGGGGDGGGAATGSGSSGANGEQEPGGEDELEEDEGTGEQQTEGAAAKRTREQKNASVFLPESARLPKQYQINRRSRSSDSSSSSSSSSSSDSTRRSRSKEPLVAANAVEGSDISSDSDVSMTSIDGKEDEREIRATEERPLKRTHSEMEREEQPRAAAADTPLPEVIKMEPLDIKDEPLDACDYSSVSEEEDFGLDDISEGEEQFTADMADDISEERDEDVKPNVEELEAAVLKEINDEEIRTNDEQDGGGGSGTCGPYVSILQAYQLKVEGTDELSSDLEAGEID
The following text describes a protein:
Function:
Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Associated with microtubules.
Sequence:
MIPGKYRSVSGRAANNVNCGLHLVIQTSSLSDKNKVEFRLNRETPPFPGRLLQHDLERNYSSRQGDHISLVSSSMPAFPILQRSSEEKTLYSDRLTLERQKLTVCPIIDGEEHLRLLNFQHNFITRIQNISNLQRLIFLDLYDNQIEEISGLSTLKSLRVLLLGKNRIKKISNLENLKNLDVLDLHGNQITKIENVNHLCDLRVLNLARNLLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQRLFLSFNNITSFESVSCLAESTSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRVASVVPKKEEEKKRESHKQSLLKEKKRLTINNVARKWDLQQRVANIASTQDRKDSESPPQESCQLDGGNISAFPEEAGSLDAGLSSALQGLSVTETHLVEIDGETLSLYGSGALECLDRNWSVQTAGMVTTVSFTFIEFDEIVQVLPKLKMKFPNSLHLKFRETNLVMLQQFNALAQLRRVDQLTIDPQGNPVVNFTLWKYYVLFRLSHFSMQKINGTEVTQNDMIMAERLFGILAHVASSELPQYRMISILGDARKKQFRYLLESKGKKPGIICEETSDSKRFLGENTNRATLNYTTREFYHEKLEEIKDKKKFCRLYVEDLVKEATAINMKNEALQKLWPQMFIELVRDAVIEIRSKDSYMKLCLQQITDQK
The following text describes a protein:
Function:
Has antibacterial activity against Gram-negative bacterium E.coli ATCC 11229. Shows hemagglutinating activity. Inhibits prolyl endopeptidase, but not trypsin, chymotrypsin, V8 protease and proteinase K. May have a role in mucosal defense against microbes by interacting directly with their membranes.
Subcellular Localization:
Secreted.
Sequence:
VIEPKCYKYEGKKCPPDINPVCGTDKRTYYNECALCVFIRQSTKKADKAIKIKKWGKC
The following text describes a protein:
Function:
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The RxxxRR motif forms an adapter helix that bridges the nucleosome and ubiquitin.
Sequence:
MANGSDTKPVPKGPRGARADDTRTPPHPDRRGSDRDQYFSKDRSYGGRTDRDYSDYDRAYPPPRDYDRYGGGKYGKYDKYDKYDRYDRLDSHDYPPRRDRDYDRSRDARDTDSRDYGRLPPRDTRPPPRGGREYRYARDERGWDRDRRDLDRDRDRDPRDRERDARDRDRDRDFRDRDHDPRDRDPKGYRPHSLDPLPSRDRDMPPRERERELVRERDLFSRDRDLITGVRELARSPPPPLRDGRNRDRSNDRHDRSFDKHTRDRGTRDRDTKEKGSVISTPQTAPTPRLTPTNGKPDLPTSQPPAPPSPPRLKTFPKEVWETVGRKNNTRLTYDPELSKDKQKGKRGIYEEVKKGASTTEDPRSKHPHYFKTSSKSNKKPYQRLPVPRFLYDANSIAPPPSTQIIVKGLSSLTTSKTITAHFKTYGELEAVNMVEDPATGSSVGACLVRFKVTKNNYEAAHECLKKAIRGQKTGRIDQAKYRVEPDEDGAKAKDIIKRVAARAAKKAMPVKQPPTAPAADKSIMEKLPTPVPSARPSPKAAQLMKTSAYIFIAGKYLPSEKVFASDIRRILRDFGWFDVLKEGDGFYVFFDNNRDTVECYEAMNGRKVNGHQMAMAMIRLSRVAPKTKESEENATEQAPKLPPKEEARKLIVQELANSLRKDIRERVIAAAIVEFLNPARFTHIKQDPEPSAATEPNTVNASAARVDTPEPVQSSSAIPGFLPRFKIKRKGDPTKKKDATKKNRKKISARPMNHVLNDYYSDEEDSTRMSTPIVPDTSADAAELPIRKPRKKISQSKQRIMDFSSSEGSNESEEEEEVEDDMEEEEDETAQEELQEASTLDTSQQLTTAFGEILDWAPAHGFPQPVTADKKGGALTTISGFQALVKDDEDMELLQEALEGIEPEKINGEAWTWTHKHLNEAVAKENAEFPELAAPNAFVNSTGSWKSQGYFKIPEAAKSEYLPHRKKLNIPIDTLQMENREKKKENASNSRVNRANNRRLVADINMQKQLLSTETDVLNFNQLRKRKKPVKFARSAIHNWGLYAIEPIAANEMIIEYVGEVVRQEIADLREARYMRSGIGSSYLFRVDESTVVDATKRGGIARFINHCCTPSCTAKIIKVEGQKRIVIYASRDIAANEELTYDYKFEKEIGEERIPCLCGAPGCKGYLN