lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
RNA-binding protein involved in RNA processing and transcription regulation. Acts as a regulator of mRNA stability: binds the poly(A) tail of mRNAs and pre-mRNAs, preventing their degradation by the exosome. Involved in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Involved in mRNA poly(A) tail length control and nuclear export. Functions in surveillance and the packaging leading to generation of export-competent mRNPs. Controls both mRNP compaction that facilitates movement through nuclear pore complexes and the length of transcript poly(A) tails. Also acts as a regulator of transcription. Associates directly with nascent RNA polymerase II transcripts and remains associated during subsequent nuclear RNA processing reactions. Required for RNA polymerase III (RNAPIII) transcription: required for the occupancy of RNAPIII and Transcription factor IIIB (TFIIIB) at target genes, possibly via direct association with nascent RNAPIII transcripts.
Miscellaneous:
MISCELLANEOUS: Present with 9670 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes to the nucleus at steady-state, it shuttles between nucleus and cytoplasm.
Domain:
The N-terminal domain is required for nuclear export of both poly(A) RNA and NAB2; The RGG domain is important for NAB2 import; Contains seven CCCH Zn fingers that bind to A-rich RNAs and fingers 5 to 7 are critical for these function. Binding A(11)G RNA induces dimerization of Zn fingers 5-7 mediated by the spatial arrangement of the fingers promoting each RNA chain binding two protein chains.
Sequence:
MSQEQYTENLKVIVAEKLAGIPNFNEDIKYVAEYIVLLIVNGGTVESVVDELASLFDSVSRDTLANVVQTAFFALEALQQGESAENIVSKIRMMNAQSLGQSDIAQQQQQQQQQQQPDIAQQQPQQQPQQQPQQQPQQQPQQQPQQQPQQQPQQQPQLQPLQPQLGTQNAMQTDAPATPSPISAFSGVVNAAAPPQFAPVDNSQRFTQRGGGAVGKNRRGGRGGNRGGRNNNSTRFNPLAKALGMAGESNMNFTPTKKEGRCRLFPHCPLGRSCPHAHPTKVCNEYPNCPKPPGTCEFLHPNEDEELMKEMERTREEFQKRKADLLAAKRKPVQTGIVLCKFGALCSNPSCPFGHPTPANEDAKVIDLMWCDKNLTCDNPECRKAHSSLSKIKEVKPISQKKAAPPPVEKSLEQCKFGTHCTNKRCKYRHARSHIMCREGANCTRIDCLFGHPINEDCRFGVNCKNIYCLFRHPPGRVLPEKKGAAPNSNVPTNERPFALPENAIIENAPPQTSFTHQEQDTEMN
The following text describes a protein:
Function:
Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.
Sequence:
GKKKRGFGEGWWNGFGGKVVDGETIVEGAKREVLEECSLNASSLAKRGIIDFEFVNDPVILQVHIFEIIKFSGQPLESEEMLPKWFNVNQIPFDNMWPDDKMWFPYLIEKKYFEGYILFEGHTKVLDCKLVLKHDGQDDNSAE
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
Subcellular Localization:
Cytoplasm.
Sequence:
MATAGSDVALAASFSELNAALKRENYSRAVDICNKIRSKFPDDVDAVKVKCVALIRLEKFDKALELAAKYDFLSTQKAYCLYRLKQDDDALKLLDGDLETQSDAQLHLAAQLFFRKGDYDQSIRIYELLLTRAQEGDDLLELQTNLLAAYASAGRSHELKDREIPDLDGMLAQVDDGFEVAFNKSFVAIQSGDWEAAEDLLLTAERLCRDTFIDEGVAEAEIEEEVAVIKTQLGFVKQMRGDLDGALSDYRNVLKLKLRDRAVAAVASNNLVTIRKDRDVLDSLKRLKNIDAAVLSDKLNPTQQEAILTNRTLLLCLMNKTDECRESLEVLKKQFPASKSIADIVLLLAIKDQSPAAAIEQLQGDVSVGARLGLAHVYLTEGQVLKAAESIRSIEELAHSSGTVATLVALYEQAGDSVSAQAVLESALAHHRAGDYTSEQAMKLREGDCWYKIQKKQYRAAADAYLELLEGEAAGALDRDLRLRSMASLVVALSFCDAEAAEARCAMLPVVEESGVDPSELEKQAPRSNRLAAKFADTGDKKNERKRAAKSPEGIARKRAKRRETHLANLRARPDYNASIGLVNPDPERWIPRKQRSHGKRGRRGRNRFVGAQGAGMGTEKDALKLDAAARAARKAESDKPAAVVVSSGSGIRKSKKKKRR
The following text describes a protein:
Function:
Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Required for proper protein transport into the nucleus.
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MPAVEKSVITDWKRLWPMVSGIHYETPQDTVREELMNVASELQAGVLQFKPKNASSLELGTLLKEKKQEKLLPFTERLQDLLDLESAQCWEILCYYLTQEYRGSASLLTQLISTETNMAKLHEDIRHYYSLERMVVLKIVKNLIVFHQVPNHPYHREYRAVVEKITIPRLRDSYLDQLESLICEVPPRKLMAGECFHSAERLVAWSERNAREINEVLHILLVLAEHLPMGLEQIKRIFAACKQHSFGKMQSYLDDSQPYHQEIIRSLSYSELMLVLKCLDFEKPEKHSDLIEKLIEDLQVDIASMYHRPEHGPLLLAWMLLRLRGTNDADDASSLLRCRQLGKRAVDLKCFVQLHLIARHSMYADDSMLSRIVRRTIYNQVGYLCDLFDGDGSCARYEGIYELLCELVSWPHLAKDFCSREDDGPCSLYKTLLENFPLELTHLSKLALSLTKAGQGNYVKSQLEALPILALRYDESQHKLREVDTNEFELLASVQPFQQIDFTIPAGTSCTAIQHPSGCFMHFRFPVNYFDALHHEINCLLRETGHLHGDFESSERIRNVEAGLRFLESAVKLSQSISGISAEMVHPTEMCVDLLHTFKSVQYPPVGLLSSCLNVCTALLPLVDEEIFSRISNLHILPTVSPGSHYDFKMYANANGVGFESRFLGSVIDNVEKKRERYEFLLSYIGFLRAYSNLKRNRQIQMEIPGLIFLLKDVFPHLHTWHFSSQVERNKIYFEILSFICDILDLFNTAKESNCKQRELLVKVCVYSLLNLENGLILLRFVGVGNAYVQYTMELETNWMQQQPHGLMMLVRLSMRILMQLLRLKEEVYGNSETLSPLEALIYTQPKQRDTLRIIPTVCSYMSNIFDRWLPILSCRLLKRIALQFNMSLLACLDMEADQIRLTFMQKLPDELESDSIKIAILELVDACIAKQPGVTEAFFKVNYALDKRSRSFFSKDCVPNIGESIVTYMRDFLDALQVDPLTIQQALPAKIMTIFHSMWKHNLQMLVDDLVKDKQFWKKLCSPLFSELQPNLRIYTQLLNIISIEVYTGNGNNAALLDVMNKFFEQKNFGPWLNYVFNMPKVPAVKNLSSSDHLPDWICCLQAFKDLIVILLKKQPKFVTIPESQFKLMAQKCLVVLVDRSNYLEDMRPFIILAELYVFILLEFKHAYTDSLEEEQTLMDLLLQLMNRICACYEDQHVRAKEACLAIVTKCTHLYTDLLIRDSSIALRFLNSVVGIICSELQHMENSVSLEKSQGLNNSDSSDSKTSTNSLILCLNLLKAVATIFHNDGPGNWDLPFVSVRLFQRLVRCVSRTLPLFSKQVLSVQLLDVLIVFAKGHCSVEFLHCDVGEYLWLKLLPPRELLQSKHEFTKTTAADAEGWTVEQWWPVYARGIELVTIIYEKHKKCFLEDAFQFVGIHAVFLEDALLLSKQSLEPSAMYLIKAAVNLVASLTEHHKEWKQDSDLSLANLMRAVQSLLCHTSSLFHQQKNLKCLLAGRRSQLEILRSTEALIVDDELISACNDLTDIIISCVKALLRFSPDLMELLCCSAYEPSKHSILLDVKFGAPKLNEENLTLTFGIVLNLVNIYVKALNMQNHGFSEVPLNSLPNVEHSGDNDDPEVCVGNQTNRTFSKPLSNVSISTGTCPASELLSNMDGQLCLLALEHLLMLVASQAICIIRSPNLETLWKQIVRRDISNELLIFNEFVRRKVILDYKENRSPWLRRKHGLCKLKCVDPVRSSSSSSRSSEIVRRSNTNNELRVNVVRRLHLQQQQRTPPPQNFDMSSDLSPIAAAQGAAMTTSLDGRKRLYPAQQAGDAFLEDELAAIELQYFPPPTEPGYCELSQVQVVEEDYLQLMSALFNVMPHCD
The following text describes a protein:
Function:
Converts fumarylacetoacetate to acetoacetate and fumarate. Involved in tyrosine catabolic pathway. Catalyzes the final step in the tyrosine degradation pathway.
Sequence:
MALQSFIEVEPDSHFPIQNLPYGVFKPEPASVARPGVAIGEYVLDLSEISKAGLFNGPILKDSDCFLQPNLNKFLSLGRPAWKEARDMLQKLLSSNEATLRDNANLRQKSLVPMGKVEMLLPMEIGDYTDFFSSMHHAKNCGTIFRGPANAVPANWYVILKSTSKQGIVSVLTLVYYSIFHLQVYRVVPYFRFHLPIAYHGRASSVVISGTDIVRPRGQFAPSGNSPPPFGPSQKLDFELEMAAVVGPGNELGKPIDVNEAADHIFGVMLMNDWSARDIQAWEYVPLGPFLGKSFGTTLSPWIVTLDALEPFACDSPKQDPQPLPYLAEKISKNYDISLEVQIKPAGKEDSCVVTRSNFKYLYWTLTQQLAHHTINGCNLRSGDLLGTGTISGPEPESLGCLLELTWNGQKPLSLDGFTRKFLEDGDEVTFTGFCKGNGYTVGFGTCSGKIVPSTP
The following text describes a protein:
Function:
Probably functions as a cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate.
Subcellular Localization:
Apical cell membrane; Peripheral membrane protein. Melanosome membrane; Lipid-anchor. Lysosome membrane; Lipid-anchor. Cytoplasmic vesicle membrane.
Sequence:
MGTAFKKFCIKFCCCCCCEDEDEEEKAPLIGHDTLDYFDREAKKRRDQETNLWSEPGDPSHSERDDDRVLYKLLQCRQQTQPGSRGYRRLSIDIEAMRDVRREVRDKWKMILENLGFMAEAESLLNVSASASYDRMRNAASARSLLQTLHTETSLFNSKEPPPERYLFILDRLIYLDAAEDFVAKARRFYPPKDDDEEEESNPLGINLPLLLSRMNQNISGGEDEDEDESEPDD
The following text describes a protein:
Function:
Required for male meiotic cytokinesis through its involvement in the regulation of mitochondrial aggregation and fusion, astral spindle assembly and contractile ring formation.
Sequence:
MNIPIYQVPSVTMQSLHQQSLYQQTYLDRNRMVTDVFVQEHVSQSSWSMAGSSAVFIPGPIITGSAHGHCHHTATVSTVSPQLATFMPFPGMQYYAASSATMNAYGHNQMYSTRASASVGFYLPQYHASCSHEQPKKTFCAAQTQTQQTAKTSCDVGTQVDLDAEELRSEARKPRPESVVPEESSISSLESGAGDGFRVQKKLRNSEVKLLDQRLHDITRVSLHGSEIAERLANAHRNRPCFKKIDTLCARLKQDLLRPDGVLPNINSQGIAWAVKDFIFVFTRIVNAWVILKGYVYNTPDALNKIKDELPSGFMASFDSWQISTLSIVKMIVKSFVNLDELLQKQKNSFSGKDGAPINQSNSISLRSFIDSNDSSGLAQKYLGMTTGHGPSAFSTPNNQIRNNAASKGQEPTSSALYKPKCALNLNYLYTMIEDSEETQRHVDANGTYLKTGTYQPLQKESMQLEMPPAKPNDHYVERNANQQALPSQEIPNAPTPKSSPQSDRPRDVRSYTNPFSAIGKEVTRQLYEFSDRVMELKNLERFFKKQFTRNYYPNFYQHCQDDFIDVRAIILRCENSSYHHIYQAIHDLRRIIFTVRCYLQMYTDENLLYYIDLYERSVNDMLSKPPHYPNQFDHIMGRPGEKLFNYEI
The following text describes a protein:
Function:
Metal-dependent phosphatase with probable damage-control functions. Shows phosphatase activity against several substrates, including sugar phosphates and p-nitrophenyl phosphate(pNPP). Prefers sugar phosphate substrates, including the extremely potent glycating agents ribose-5-phosphate and erythrose-4-phosphate.
Domain:
Subfamily II proteins have an EGMGR motif about 50 residues from the C-terminus (Probable). This motif lies near the metal-binding residues in the putative substrate-binding cleft 2 (Probable). Subfamily II proteins occur only in eukaryotes, in two forms: as a stand-alone unit in plants, and as a C-terminal domain of pantothenate kinases in plants, animals, and chytrid fungi (Probable).
Sequence:
MESDSEMVPFPQLPMPIENNYRACTIPYRFPSDDPKKATPNEISWINVFANSIPSFKKRAESDITVPDAPARAEKFAERYAGILEDLKKDPESHGGPPDGILLCRLREQVLRELGFRDIFKKVKDEENAKAISLFPQVVSLSDAIEDDGKRLENLVRGIFAGNIFDLGSAQLAEVFSRDGMSFLASCQNLVPRPWVIDDLENFQAKWINKSWKKAVIFVDNSGADIILGILPFARELLRRGAQVVLAANELPSINDITCTELTEILSQLKDENGQLLGVDTSKLLIANSGNDLPVIDLSRVSQELAYLSSDADLVIVEGMGRGIETNLYAQFKCDSLKIGMVKHLEVAEFLGGRLYDCVFKFNEVQS
The following text describes a protein:
Function:
Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It prefers the antibiotic chloramphenicol.
Sequence:
MSNVQNASRSSAFAAVEGDHWVESLDDGRHVLIRPLREEDRERERQFINRLSPATRHFRFLGEIKEASPALLDQLMDIDYQQSMAFVALVHEDGELREVGISRYAACCEEGQCECAVTIADDYQGLGLDAVLMRHLIDVARRNGFRQMYSVDSAANRAMRDLCCALGFVGQRDPDDSTQVIHRLAL
The following text describes a protein:
Function:
Probable transcription factor (By similarity). Involved, together with PDF2, in the regulation of flower organs development by promoting the expression of APETALA 3 (AP3) in the epidermis and internal cell layers of developing flowers.
Subcellular Localization:
Nucleus.
Sequence:
MLTMGEGNVMTSNNRFASPPQQPSSSSPGTIQNPNFNFIPFNSYSSIIPKEEHGMMSMMMMMGDGTVEEMMENGSAGGSFGSGSEQAEDPKFGNESDVNELHDDEQPPPAKKKRYHRHTNRQIQEMEALFKENPHPDDKQRKRLSAELGLKPRQVKFWFQNRRTQMKAQQDRNENVMLRAENDNLKSENCHLQAELRCLSCPSCGGPTVLGDIPFNEIHIENCRLREELDRLCCIASRYTGRPMQSMPPSQPLINPSPMLPHHQPSLELDMSVYAGNFPEQSCTDMMMLPPQDTACFFPDQTANNNNNNNMLLADEEKVIAMEFAVSCVQELTKMCDTEEPLWIKKKSDKIGGEILCLNEEEYMRLFPWPMENQNNKGDFLREASKANAVVIMNSITLVDAFLNADKWSEMFCSIVARAKTVQIISSGVSGASGSLLLMFAELQVLSPLVPTREAYFLRYVEQNAETGNWAIVDFPIDSFHDQMQPMNTITHEYKRKPSGCIIQDMPNGYSQVKWVEHVEVDEKHVHETFAEYVKSGMAFGANRWLDVLQRQCERIASLMARNITDLGVISSAEARRNIMRLSQRLVKTFCVNISTAYGQSWTALSETTKDTVRITTRKMCEPGQPTGVVLCAVSTTWLPFSHHQVFDLIRDQHHQSLLEVLFNGNSPHEVAHIANGSHPGNCISLLRINVASNSWHNVELMLQESCIDNSGSLIVYSTVDVDSIQQAMNGEDSSNIPILPLGFSIVPVNPPEGISVNSHSPPSCLLTVGIQVLASNVPTAKPNLSTVTTINNHLCATVNQITSALSNTITPVIASSADVSNQEVS
The following text describes a protein:
Function:
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules (By similarity).
Miscellaneous:
MISCELLANEOUS: Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell-induced activation of PLC, maybe by inducing the dephosphorylation of LAT.
Subcellular Localization:
Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.
Sequence:
MEADALSPVELGLLLLPFVVMLLAALCVRCRELPASYDSASTESLYPRSILIKPPQITVPRTPATSYPLVTSFPPLRQPDLLPIPRSPQPLGGSHRMPSSRQNSDDANSVASYENQEPARKNVDEDEDEDDYPEGYLVVLPDSSPAAVPVVSSAPVPSNPDLGDSAFSMESCEDYVNVPESEESAEASLDGSREYVNVSQDAQPVIRAELASVTSQEVEDEEEEDVDGEEAPDYENLQELN
The following text describes a protein:
Function:
May play a role in mRNA degradation.
Subcellular Localization:
Nucleus.
Sequence:
MAETSEKIKFLVADTTAFINAVPLNEYAEQVLTVPDVVAEVRNKRQIRRLCVLPFDLQVREPRPESIKHCVEFAKKTGDYASLSGIDLKVISLTYELEADNVGTDHLRQEPVMAQTIASKDKPEEMQDANNKRLVGWYMPEGEEEEEEDSEEEDDYSQEEDDAEGDEQEANESPDTVKAAIEAQLAGKEPFASETIEKEEDQDQEPSQEELDKLFEQLKCAPSAEEEKELSELLVSQPAEVDEEVSEPQEAKQSQNLDEDVGDDGWITHSNIKKAKKALEGKVETDEVPPVACMTTDYALQNVLKQLNLHLAALNGRIIKQLRTYILRCYACYKTTSIMTKVFCPNCGNKTLKRVAVSLDENGRQVIHINTRRPLTNKYKNQSLPRFQGGKHSRNPILFEDQPMPRQMPSRVAKTKTNALDQDYTAGFSPFVLRDVDSKSAMLRSKGNLKEWARNNNFEEDRRRKNYNRLYK
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase, component of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates.
Subcellular Localization:
Nucleus.
Sequence:
MSFFSRNINSKDRHKIQIISNSTAPSFEPNNEFVTSSCCCCGTILQHPKNISKFRCSVCYVTVVLQGTAFTQDKTELFDLDDMRELLSSCNNTYRELDKDEKRLRKHEVFHLLEDYIATRMVTIFPLNASFESSNPREMLDYDQVKEFYRILMELPTKKPFYSFLVACNELLKRPHVALNTPTPTNPKYKRIGLFRWILIILEVPIFKQTLANAEARCNTPHFRAISYEVLKKAVGYMSCLDEASAKELVHFLKYMQKDIFASKVELVNMYITFHFARILHTIGKETNNGKYSPQLEDFEHSEKLNPSLNQGSAKKLVHTNMNIFFGGIVRPMTSSANSKDILALNYRFSPEDYGNEWHIKTGARLLLCLYVANQSAYKCPVSNFYNTMIDFVDYKRDFELWQDLSKLSASHEKENSGSSGPRYSPVQFTICQCPFLFSLGMKISILEYETRRLMEYSAEQAFLKALDRKQVVDVYLKIRVRREFVTTDSLRSIQNQQKDLKKSLRIEFVNEPGIDAGGLRKEWFLLLTRDLFNPNNGLFVYVPESRLCWFSIMESIEHELLQGEGSSSELYYLFGVVLGLAIYNSTILDLKFPRAFYKKICGEVLSVNDFLELYPETGTNMLKMLEYDGEDFEDIFALTFETCFPDRFDESKIHYRQLCPDGSTQAVTRENKHEYFRLWMDFYLNRSIAPGFESFRNGFFHVIEGNSFRLFGSEELEQLVCGSNEQSLDVSMLRSVTRYQGGFDDNSPVVQWFWEILSEMEYPQQRKLLHFVTGSDRVPATGVTTIPFRISRIRSGADRLPLSHTCFNEICLHEYKDKETLRNKLIIALEESQGYGFR
The following text describes a protein:
Function:
Could be a melanogenic enzyme.
Subcellular Localization:
Early endosome membrane; Single-pass type I membrane protein. Melanosome membrane; Single-pass type I membrane protein.
Sequence:
MTFKIGCLEMHPSTLGGRGFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYPVWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFVVNLVFPRCQKEDANGNIVYEKNCRNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFVYVFHTLGQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFVTMSQKNDRNSSDETFLKDLPITFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSINHTVNHTYVLNGTFSLNLTVKAAAPGPCPPPPPPPPRPPKPTPSLGPAGDNPLGLSEIPDENCQINRYGHFQATITIVEGILEVNIIQTTDVLMLVPGPDSSLIDFVVTCQGSIPTEVCTIISDPTCEITQNAVCSPVDVDEMCLLTVRRAFNGSGTYCVNLTLGDDTSLALTSTLISVPDRDPASSLRMANTALISVGCLAIFVTVISLLVYKKHKKYKPIENSPANVVGSKGLSAFLNRAKAVFFPGNQEKDPLLKNQEFKGVS
The following text describes a protein:
Function:
Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
Sequence:
MKFDPQKYRELAEKDFEAAWKAGKEILAERSPNELYPRVGFSFGKEHPLFATIQRLREAYLSIGFSEVVNPLIVEDVHVKKQFGREALAVLDRCFYLATLPKPNVGISAEKIRQIEAITKREVDSKPLQEIFHRYKKGEIDGDDLSYLIAEVLDVDDITAVKILDEVFPEFKELKPISSTLTLRSHMTTGWFITLSHIADKLPLPIKLFSIDRCFRREQGEDATRLYTYFSASCVLVDEELSVDDGKAVAEALLRQFGFENFRFRKDEKRSKYYIPDTQTEVFAFHPKLVGSSTKYSDGWIEIATFGIYSPTALAEYDIPYPVMNLGLGVERLAMILYGYDDVRKMVYPQIHGEIKLSDLDIAREIKVKEVPQTAVGLKIAQSIVETAEKHASEPSPCSFLAFEGEMMGRNVRVYVVEEEENTKLCGPAYANEVVVYKGDIYGIPKTKKWRSFFEEGVPTGIRYIDGFAYYAARKVEEAAMREQEEVKVKARIVENLSDINLYIHENVRRYILWKKGKIDVRGPLFVTVKAEIE
The following text describes a protein:
Function:
Binds to F-actin and may modulate the chemotactic response during early development and contribute to the maintenance of the strength of the actin cytoskeleton.
Subcellular Localization:
Cell projection, pseudopodium. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
MSSICPTCTKRVYAAEAVKACEKQYHKLCLQCFHCHKILQLGQYSERDGQPYCKTDYDRLFRQAGYRGGGVVADSFEPAPKVETTTPVEPTPPPTFLTPTEEVKVQLFPTNCPKCGKKAYFNELKVYNSRDWHKTCFACFSCNKNLVSGQYSEKEGLIYCPRCYQSKFGPSGYTNTGALVLH
The following text describes a protein:
Function:
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
Subcellular Localization:
Secreted.
Domain:
The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues; The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
Sequence:
MSGAGGRWKGPVGGRAVSESVNKRHNVPPQFHFLVQFHSCAAVSEPLSLGSVSGVSSAPQCRGLNLQADTPSYKMKLWVPLVLLVCGATKCEEPGIKGRLTLKGLHYGWQVVLEEVQRRLSSLQIPDVSGSVSVPVLGAIYYSVSSLQIQELDLSHSDASFSSDTGLKVSVSDGRTRVTGYIEIRTVLFGTSSSLEVSVDGLSLSAVLGLTRDDAGRGALWNAGCSSSVGQVDLNFHGGSGWILSMFKGSMLGPIHDAFSQQLCPQFDRSVVQMETLLSSLPVTEPVDSVAALELSLVSPPLITEQNVDLLVRGQFVGLSQRWDVPYSPVEMDLPDAESRMLVLAVSQFSANSASYVHYKSGALRANITDDMIPKESPLRLNTKSFAAFAPELPNRFPGSPPLLLQLSAPSPPEVTCQTDLLTLGASLDIQLSALYPESPPAPAFQLQAVDELQHMMSFALKVIGFPLLNKKLQKVFPIPTPLVRLQSPTVRVFQGFLLVVSDLEIDPWTQYQKVSDVAWEIPKTHKPSPFL
The following text describes a protein:
Function:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Sequence:
MPQKRLPGINPKTNGFVARKRKPKLTRQSVLKMLAVMEASRNTNPPVSKDETTPPTPSSEDARPQDFLQSGRTGRRNALANILGEHAIVTSSDLPAQLEALTTKDTPENPDNNQASTSKS
The following text describes a protein:
Function:
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MNLDGGDRRRIVSRAGRSILLDFHLSEWTMFWADTQTGQISRAGLDGTRRQKLLSSVKGITGLVVDWIENSVLWSNADEGTIQRMDTDGKNDRVVLRNLSQPRGVVVDPNERYIFWLSDGATSSIQRSDMTGKMMSTVLKVADRLKVLAVDHRDRRLFWVQQGQRGHTAMGSCNYDGNIINVFNQQFRPQSLRMTIFLDYVYLSDSKSKTITRLNKYAGGRQENVSSQRMPHSPADVKVVHPINQPVVETPFTPGCSRHTGECVKVCSSHTDTGLCGCKDGFTLSKHGNICEDVNECSLWNHGCSLGCENVPGSYFCTCPEGYLLLPDLKTCQENKPCVGKAVDCDHACVHTAQGDMCVCPEGSLLNPDGQSCTGCLSADRGGCSQMCVTLYPGRWVCECHPGYQIQPDGKHCAATGPPADLLFANIVDLRKINTDGKLSIKLLEKPGGNITAVDYDPVTNKVYFADKGLKHIERASLDEGFRELLVSTGLNSPEALAVDWIQRKLYWTDSGLSSISRSSLNGLDREIFINENIQKPRGIALHPQAQKIYWTDMGDRPAVERSGLDKDLREAVVSTGLVSPSGLAVDHGSQRLYWCDMSTSVIESANLDGSHRRVISQNQVDRPFDIAVFENVLWVSDLENHLIFRLDMRSDQNPERLLVDSIQPAALVVVHPLAKPGADVCLDGNGGCAQVCASRLGLPHCSCHTNQVLSADGKGCRMINGSFSESSEGGSNDGLRNKTLNDESTPLAMLYTEKMVSDQDDCFSLSCVVNAQCFLQEGRAVCQCVRGFTGDGELCVDVDECKAGLADCSVSEAECVNTAGGYFCQCKNGFSGDGHHCVDIDECRLDLHDCDVNAECLNAVGEYQCRCRSGFTGTGFSCQAEFNGTSLWPSTASPPDVTSTLQHKNGVQSCPSTHDSYCLYDGVCFYFPEMESYACNCVLGYMGERCQFSDLEWWELQQAEEGKRRNMVIAVCIVLLITILSIAACITFCYRPKRHFGGCSLQDSVGEMSASEDSFTETTTATPEVYVVLDTSTCTADKVLHVQSTTSTICSSCPTQTGDRFSSEEAGKLQRDGCSLAVAICSVSCDIPKILLTEKTTDNLISLEDAQSPTSSQ
The following text describes a protein:
Function:
Participates in the periplasmic electron-transferring activity of hydrogenase 2 during its catalytic turnover.
Subcellular Localization:
Periplasm.
Sequence:
MNRRNFIKAASCGALLTGALPSVSHAAAENRPPIPGSLGMLYDSTLCVGCQACVTKCQDINFPERNPQGEQTWSNNDKLSPYTNNIIQVWTSGTGVNKDQEENGYAYIKKQCMHCVDPNCVSVCPVSALKKDPKTGIVHYDKDVCTGCRYCMVACPYNVPKYDYNNPFGALHKCELCNQKGVERLDKGGLPGCVEVCPAGAVIFGTREELMAEAKKRLALKPGSEYHYPRQTLKSGDTYLHTVPKYYPHLYGEKEGGGTQVLVLTGVPYENLDLPKLDDLSTGARSENIQHTLYKGMMLPLAVLAGLTVLVRRNTKNDHHDGGDDHES
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MPRLPPILRLLQAPAKFTVVPKAHVSAKPAKTPTSAVEQAVGISAIVVGFMVPAGWVLAHLESYKKSSAA
The following text describes a protein:
Function:
Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Sequence:
MVTAALKRFWSGGHGEAGGEAGGATTVAVKPGLWTRLSTWAGALLRDYAEACGDAAAAARARPGRAALYVGLLGGAAACCALAPSEAAFEEALLDASGSLLLLAPATRNRHSEAFLQRLLWLRGRGRLRHVNLGFCSLVYEAPFDAQASLYQARCRYLQPRWVDFPGRILDVGFVGRWWILQNRMHDCDINDDEFLHLPAHLRVVAPHQLHSEANERLFEEKYKPIILTDDQVDQALWEEQVLQKERKDRLALSEADSLVQSDVSR