lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 639 molecules/cell in log phase SD medium.
Sequence:
MERPGLVLQDLPPEILINIFSHLDEKDLFTLQELSTHFRNLIHDEELWKNLFKSRVHTTHFPTFSQSSKFSVEYIERTRGLHHWQHNKAIRTKYTIIPTRNWDQPSIERIVFDYPRVAAYNDGTITILQLQNHKRQKKFKKLIYIPCTTPQGCSTMDFNINAAVFGRFDGRVFGKLLSNKSYLTPVMEFTGRHSAGVTAICNSESWDTSREDWSVSGSENGEIIWWCENKLVKMWKVSNRVIWKLAFFKDWTLIMDDEKLYIIHQMQELHSIDIPKDLDEQPMRVRFFKMDFGSMTLVLADLNNVYTISVNPNGNFGNLRKLEMPEQICAVEIDEKTSQREQNWQFAGDDGCYISLLTTQNTLYIINIRDLSSSGLKVQCKISFDEQVYVSQVTNLIVVVALPNVLQILNAMTGELIKTVLKTEKFPEFLKVSQDKIIMGSGNVLNYLKFVSSDSKKHHHSTKGKNTVSNKWNETLNTELQYYDEDEDLRRKRQSEISRLIDAYGGDLELSGDTDEENDIQLRIALLESQEAQARNQAEAGEPVGDDEDEQLRRALEESQLIYETQTNSSANHGNNTNDEIDEDDEEFLRAIRQSRVEDERRRHLRNHTTGRRNGPLSDDNFATYGAAESSERTSTENTIGSSVGVDASNNVDEDLQLAIALSLSEIN
The following text describes a protein:
Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response (By similarity). Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum membrane. Mitochondrion membrane. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity).
Domain:
The SH3 domain mediates homodimerization.
Sequence:
MAERESGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRPPRAGLLSAGSSGSAGSRLQAEMLQMDLIDAAGDTPGAEDDEEEEDDELAAQRPGVGPPKAESNQDPAPRSQGQGPGTGSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQGSPVPTQDRGTSTDSPCRRSAATQMAPPSGPPATAPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDPAEPTSTFMPPTESRMSVSSDPDPAAYSVTAGRPHPSISEEDEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASASSPYESAIGEEYEEAPQPRPPTCLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCVINGEEHEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWIDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDALEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE
The following text describes a protein:
Function:
Plays an important role in organ size control. Acts as negative regulator of the anaphase-promoting complex/cyclosome (APC/C). Regulates cell proliferation during early development by targeting CYCA2-3 for APC/C-mediated degradation. Required for mitosis I during pollen microspore development.
Sequence:
MNGASPAHSLVSTTAVAGGGGSSGAAAGLDDFHFPPDIPSMQERKDEAMRVLKADLMTELDKEVKSLEEDSWMFEGPRSRIHLISRRGNFLKKGGEVKLW
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MLGNLRISRELQEDANINDGSIHQSAPQPSSVTAACAATQHPDSCSDTLKNSTHSDAKIYTSTTVAAASSGIEETRLSVKNSETPENAPAVEVCEDTLNSALAVLEAVLEELKTVDAASFDEIKTRVTAAMEFHTTCMDALEEVGGPISTSVQLSTERAKQLFSVALSFVNAYASFGNDFLAWAKSSGLDLTQFNLHRRRLFPLTALHGPTAPPAPNQACKRHYKVTVAWNGSGDFKTITEAVNKAPTKSETLYVMYIKAGTYNEQVILKTSHFNIMFLGDGATQTIITGRLIVASGVTAYKSATLIVEGQGILAKGIQVCNTAGSKGRQAVAMRVSADQAAFYQCTFDGYPDTLYVHNHRQFYRDCTVLGTIDFIFGNAAAAIQNCRITAKKSTMEGQTNVYTAQGKMDRGSELHIPELHIQCNSFQSCTFDATSELPKSYKTYKTFLGRPWKEYFTTVLLRSKIRAHVDPKGWMPWNASDYRLETSFFAEFESKGPGALPNSGVPWLKQIKTLKEANRYQANKFIQGHTWVPLTKFPYPSAPLKYTSDFKPLSLIPFSSDRSPDE
The following text describes a protein:
Function:
Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL7, controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. The PCL6-PHO85 cyclin-CDK holoenzyme has GLC8 kinase activity and phosphorylates and inactivates the phosphatase PP1-2 inhibitor GLC8, causing activation of PP1-2, which then dephosphorylates and activates glycogen phosphorylase. PCL6-PHO85 also phosphorylates YJL084C.
Miscellaneous:
MISCELLANEOUS: Present with 1240 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSIKGDSPSSTNASSSPKSTYSIQSDDKANLGSGNVDIRTDNSQQDSNNRRDIVVVTRVASEETLESQSSTSSMGIRPESSFNYEDASNQARVEMNNRVHGSNMNTINKYYPVRFPKNNERQLSDTNNLNEKVQGTHTVQSSTQEDKILDGDTSNSQVTPSLNIAEFPTDKLLKMLTALLTKIIKSNDRTAATNPSLTQEIENGRCLALSDNEKKYLSPVLGFRGKHVPQIGLDQYFQRIQKYCPTTNDVFLSLLVYFDRISKRCNSVTTTPKTNTAKHESPSNESSLDKANRGADKMSACNSNENNENDDSDDENTGVQRDSRAHPQMFVMDSHNIHRLIIAGITVSTKFLSDFFYSNSRYSRVGGISLQELNHLELQFLVLCDFELLISVNELQRYADLLYRFWNNAKAQSQALVTGM
The following text describes a protein:
Function:
Member of the two-component regulatory system PprA/PprB involved in biofilm formation by controlling the expression of many related genes including type IVb pili major subunit flp pilin, adhesin bapA or cupE fimbriae. Functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to PprB.
Sequence:
MFEFSRSSSAEAERPEPFSQEGPALWSASLRSWDLCFEMDEQDRVIRVGGRQAYRLQCAHGLGEQPRPFAEYLERRAPGAPTLAGLRRGERLDLTLRSDAAAPLTCRFQPMQPLDGLGRSLLLGMDISDLNWQSDSQQHQLQSLSLGKLILSRLRHVSHGHLAEAVQEILESLSGAFQMQAIALLLGDGKGFCTVFASHVRPGSDSLLRPPLQLADDDLREGAGARLLRRGEGASTLLRQIGEDALYLVPATMRGGRLGALLVRPMSLEQLAQGPAPQDWQYLAELLANQVADRCELHEQHDSSRKLGLLQEMIGGGWWRYWAEQELFELAPALHDSLGLTGEYRRVPLEHLQGLLQPADADELGLRLRASLRSGQALAQDLCLRQPDSRGERRWLRIEGRPLGRGSALGLSGVLLDISEGRRQEERAQAAHARLRSLIDSAPVVIYVQRVEQGHLVPEFYSESASNLLGLDLQGQSWQALAERVHPDDLEAFFARGRELLREGRVKTRYRLADGQGNWHWLYDEAKLLRDAQGLPSEAVGLWLDVTEQHLAAQRIAESEERYRVLVEDSPALICRYTADLVLTYVNRTFADSLATSPERLVGRRLDEWLAAEDASALRARLLGSPREGASEVPELRFNLPGQRFLWLVWAERPLFDARGELCEVQAVGRDNTPVRRAQQQLAQGAKMASLGEMVSGLAHEVKQPLHVLRMTLFNMRQRMNSVGLDGDYLGEKLERMDAQVLRVDRLVSHLGVFSRKSALEALPFDPYAAFEGALGLLGEGLRQHAIEVECPAPTQRMVVRGQADQLEQVIINLLANARDALLGNPGLASRRVRLEQVACREPGWVELHVHDNGGGIEPLLLERIFEPFFTTKAEGKGTGLGLSVSHDLVRNMGGSLTAANQGEGALFVVRLPLAAPAEAGG
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Sequence:
MLSKEEEEINKVRFENYIKKLIDNGFFKCGIIDIDSGDMICISEEFNVCYVEYQEILNLFNGSSSISLLINGDRYYVNTSDDIRIQGKTTLKSSGNTSTINGLQSLIIRRTKGKCVIGVYKENQTKELAEKYIEEIIDDITKLNENENISNLIEE
The following text describes a protein:
Function:
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
Subcellular Localization:
Nucleus.
Sequence:
MDASEVEFLAEKEQVTVIPNFSLDKVYLIGGDLGPFNPGLPVEVPLWLAINLKQRQKCRIVPPQWMDVDKLEAIKDQERREDTFTPMPSPYYMELTKLLLNHAADNIPKADEIRTLVKDTWDTRIAKLRLSADSFVKGQEAHAKLDNLTLMEINTIGTFFTESLNHMYKLRTSLQTPEEGQSQDY
The following text describes a protein:
Function:
Cytochrome P450 that accepts electrons from the iron-sulfur ferredoxin FdxE encoded by an adjacent gene.
Sequence:
MTTPGEDHAGSFYLPRLEYSTLPMAVDRGVGWKTLRDAGPVVFMNGWYYLTRREDVLAALRNPKVFSSRKALQPPGNPLPVVPLAFDPPEHTRYRRILQPYFSPAALSKALPSLRRHTVAMIDAIAGRGECEAMADLANLFPFQLFLVLYGLPLEDRDRLIGWKDAVIAMSDRPHPTEADVAAARELLEYLTAMVAERRRNPGPDVLSQVQIGEDPLSEIEVLGLSHLLILAGLDTVTAAVGFSLLELARRPQLRAMLRDNPKQIRVFIEEIVRLEPSAPVAPRVTTEPVTVGGMTLPAGSPVRLCMAAVNRDGSDAMSTDELVMDGKVHRHWGFGGGPHRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS
The following text describes a protein:
Function:
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation.
Miscellaneous:
MISCELLANEOUS: Present with 38016 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus. Nuclear import may occur via redundant pathways including one requiring the karyopherins PSE1 and KAP123, which also participate in nuclear import of ribosomal subunits.
Domain:
The UBA domain is required for the stability of EGD1.
Sequence:
MSAIPENANVTVLNKNEKKARELIGKLGLKQIPGIIRVTFRKKDNQIYAIEKPEVFRSAGGNYVVFGEAKVDNFTQKLAAAQQQAQASGIMPSNEDVATKSPEDIQADMQAAAEGSVNAAAEEDDEEGEVDAGDLNKDDIELVVQQTNVSKNQAIKALKAHNGDLVNAIMSLSK
The following text describes a protein:
Function:
Involved in nuclear mRNA splicing (By similarity). Essential for growth.
Subcellular Localization:
Nucleus.
Sequence:
MAEKLPAPLLALFAPRPPLRYLPPMDVPPEKRSTPRVSGIAKYLKYAQSHDQQYHPTESLEEKRLRLRDEKQKQQRERLRSMIKVWDPDHDRHVIGDPYKTMFLSRLSYDTKESDIEREFTRYGPIERIRVVRNKVTGKSMGYAFVVFERERDLKVAYKASAGLMLNGRRIVVDVERGRTVKGWLPRKLGGGLGGRHYTKERPRRERGSRFRGDSGFRGGYRGGFRKSSGGGSRFGRGPTRSSHSSDYGGRDSSPKRRRYN
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MEGEAGGSSSVSSSPCSSCGGGADGNGGGGVVEYLIGVIEKAGSYGGYRKTQRKECLNLARTLKLLVPLLEEIREARRAADSPAGDGLDAALVRLRQAVVAANKLLKQCHCGSKIYLMLESEAVVSRFHAVYYKLNEALDDMPYDELEVSVVVQDQVELMRMQLKKAQKRRDTPDIELAMDLMVVLSEKDDRNVDNAILQCLANRLELRTFCDLKAEKVAISKLVKQFGKDAQNIRQIMGLFGKFKRIIGFEEPSAQDFSVSSRTLVKLPSLSIPHEFLCPITLEIMTDPVIVATGQTYERESIQKWLDSNHRTCPKTGQILHDLSVVPNYALRNLILQWCEKNDFELPRKAISVGSDGSSSELVKQISCLVQDLSSSQLNARRHAILELRTLSKDNPDSRILIANMGGVTPLVQLLSFPDSKIQEHAVTALLNLSLNDANKRVIAREGAIPPIIDILQNGTDEAQENSAAALFSISMLDENKVLVGSANGIPPLLDLLKNGTVRGKKDAATALVILSLHQANKSRAIKAGAIPLLLDLVKDNNLGMIDEALSILLLLASHPEGRGKLGRVSFIKTLVEIIKNGTPKNKECATSVLLELGLQNSSLVRASLQYGVYEHLVEIARNGTNRGQRKAYSLLQHI
The following text describes a protein:
Function:
Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MFEIHPVKKVSVVIPVYNEQESLPELIRRTTTACESLGKEYEILLIDDGSSDNSAHMLVEASQAENSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIRPSSKENE
The following text describes a protein:
Function:
RNA-binding protein which functions together with alg-1, a component of the miRNA loading complex, to modulate the processing and activity of specific miRNAs such as miR-58 and let-7 to regulate gene expression at the post-transcriptional level during embryonic, hypodermal and neuronal development. Promotes the lsy-6-mediated repression of cog-1 in uterine cells. In embryos, may play a role in the DNA damage response.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes to the cytoplasm and nucleus in the germline, oocytes and early embryos. Does not localize to the cytoplasm of somatic cells.
Sequence:
MMIKVGAAINGTDSPKAMKREHDNDDGDRTGRHKRPKTDGFTEAIQQGKFEVRLLVSSKSAGAIIGKGGENIKRLRAEFNAHVQVPDSNTPERVCTVTADEKTVLNILKDVLPRLEDNFSERDPCEVRMLVHQSHAGALIGRNGSKIKELREKCSARLKIFTGCAPGSTDRVLITSGEQKNVLGIIEEVMKELKEIPIKGSATPYLPAFNYDPSNISDYGGFPGNMPAGGPPNNRGPAPQRGGQGPPGGPRSYGGAITQGGGQRSFEAGDFQQFRGGPGPVPGYAMSAPGYPPQQGQFGAPNNAGYGYGPGGGGPVTTAQVTIPSDLGGTIIGRGGERIARIRQESGAQITLEQSNGQPERIITIKGTEQQIHSAQYLLQQCVRNSTQGRERFGGSV
The following text describes a protein:
Function:
May act as a bridging protein that binds pectin and other cell wall polysaccharides. Probably involved in maintaining esterification of pectins (By similarity). May be involved in the specific O-acetylation of cell wall polymers (By similarity).
Miscellaneous:
MISCELLANEOUS: Contains 2 motifs that are conserved in esterases, but it is unlikely that this protein belongs to the catalytically active pectin esterases.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MSQRWSRKKSRLPLAGLLFILVVTFMILFNERSIQQIHHHAASHTQNLREPSTFDFVKPNVPRINYLGAHEVLDRFSKCNSTKEYSGKKIGWVDPFEDHPGQVTKEEQKCDVFSGKWVFDNSSSYPLHKESQCPYMSDQLACQKHGRKDLEYQHWRWQPHACNLKRWNAIEMWEKLRGKRLMFVGDSLNRGQWISMVCLLQSVIPRDKQSMSPNAHLTIFRAEDYNATVEFLWAPLLVESNSDDPVNHRLSERIIRPDSVLKHASKWQHADILIFNTYLWWRQDSVKLRWSSEEKGSCEEVKSAEGMEMAMDSWGDWVANNVDPNKKRVFFVTMSPTHQWSREWNPGSEGNCYGEKKPIEEESYWGSGSDIPTMRMVKRVLERLGPKVSVINITQLSEYRKDGHPSVYRKFWEPLNEDRLKNPASYSDCTHWCVPGVPDVWNQLLFHFL
The following text describes a protein:
Function:
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MTLAPTEPSFLTYNDRIQEGDTVIVYVTYGQMVPTVVKRGQTLMMKYGALRHEFIIGKKWGQRLSATAGYVYILRPSSDLWTRSLPRRTQILYTADCAQILSLLDAKPGSVICESGTGSGSLSHAIALTVAPNGHLYTHDIDETRTSKVLEEFKTHGLSSVTTAVVRNVCTSGFHVENDADGVFLDVPAPWEAIPFAAKSISRKRGGRLVSFSPCLEQVQRACLAMSAAGFISIETIELVPEQKKIVNQHRQTLEEFEEIGDAYPKERKRNAEGEVKEDSRVSTAIVFPYSQPTHTGYLTHATLLPVLE
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs. Binds the APUM-binding elements (APBEs) in the 3'-UTR mRNA sequence of CLV1, PNH, WUS and FAS2.
Subcellular Localization:
Cytoplasm.
Sequence:
MATESPIPIIEASGKWGSANMGIEDLESVLTSQRFQRRKGTLPPIRSGSAPPSFEGSYAAFQNLLFRQNPNNTGISESEEQLQAGPSYLEYFGENRYLFRNVRGTGSNKRLASFDVPSSSSIWSDHSFLSAHSEESSVNESPRLEDLSQAQSSASNHSYPFIEERNAEAGSPSMDRIGGNMVVNSPLNTSLNTRPQEHGSIDGVADADVSAIRNGMISLDISNFLKLENENVHVGPHPQTVPLTQPYFGTNQFPQNPTHFSPEVQPIFQPHYATHPGYTSPETPLYPNMLPTGYFPQPYAIGGYAFNPPPVSPYATGYLPNNLFPVPFGIMVPSFNGQGQSQSQSQTSGANVQQANNFYGHFALPLLSQDHILQSLGLVSHVNLSSRSVGTTNPYYLGSPTYMDFAQFPNPPSASPLLPESPISGVSYHGRRNESVYGGWKGHTDPKTNSLLEQLKTSKGRRLELSEIYGHIVEFSVDQYGSRFVQQKLEVCSNEEREAIFKEVFPHASKLITDVFGNYVIQKILEYGNAQQKREFWKQLEGHILPLSLQMYGCRVIQKALEAFELEQKIKIVRELEGNIFECVRDQNGNHVIQKCIECLPTENTKTMILSFRGQVELLAKHPYGCRVIQRVLEHSTDEVQSRFIVDEILENVYVLAQDQYGNYVTQYVLEAEKPEVRSQIVDKLLGHIVRLSQHKYASNVVEKCLEYGDEAIRKILIEEIIECADGNDNLLVLVKDQYANYVVQKVLQICSDHQRKVLLSRMKGHLNLLKTYTYGKHIVARFEQLYGEEIAALGSNMSDGKSV
The following text describes a protein:
Function:
Assists the correct folding of nascent IpaB. Once it is bound to IpaB, it binds to IpaC and impedes their premature association that would lead to their degradation in the absence of IpcG.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLNITENESISTAVIDAINSGATLKDINAIPDDMMDDIYSYAYDFYNKGRIEEAEVFFRFLCIYDFYNVDYIMGLAAIYQIKEQFQQAADLYAVAFALGKNDYTPVFHTGQCQLRLKAPLKAKECFELVIQHSNDEKLKIKAQSYLDAIQDIKE
The following text describes a protein:
Function:
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.
Subcellular Localization:
Nucleus.
Sequence:
MLDCSDYVLDSRMNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQ
The following text describes a protein:
Function:
Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block by Mg(2+). Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits. Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits. GluN3B subunit also binds D-serine and, in the absence of glycine, activates glycinergic receptor complexes, but with lower efficacy than glycine. Each GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane.
Sequence:
KCCYGLCIDLIKLLSRDIGFIPVIETIQGGRAGSFKNGKWTGLIGEVVAGNADMAMSSISITSQRSKFVDFSEPFIHTGSTILVAKRHGSFKGDGFLKPFKVSAWLLIFAVLYLVAVVVLLFESHNPGLQRQKHRNYRGEFDIHQSVWLMFSRFFSGILNAPIPRFVSSRVVLSSWSFATLMIDALYTANLAAFMVLQDQAHYIDGINDSRIQNPLASVLKFTTIRDTSVEKYFKINFPHVYSFMRNYRFNHSSEGVRAVKEGYVIVIDAFIWESATMERYVANDTRCSLLTVGKLFDTSGFAAAFPKGSPWTRNISDFILKYQQTDVQGELRDKWQK
The following text describes a protein:
Function:
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, Cortical granule. Lysosome.
Sequence:
MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQARTQLQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVYQDSYGTDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDRFIHLGGDEVEFKCWESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTIVEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQEQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAAQPLYAGYCNHENM
The following text describes a protein:
Function:
Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAAAPPLTKAEYLKRYLSGTDAGLEGGPEAGRKRRKKRPKPGGAGGKGMRIVDDDVGWAAISTAKPEKEEEEDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHGEDGHFHHDDQDSSPPRRVRHDTPDTSPPRKARHDTPDPSPPRKARHDTPDTSPPRKARHDTPDPSPPRKARHDTPDPSPPRRVRHDTPDLSPPRRVRHDTPDLSPPRRVRHDTPDPSPPRRVRHDLDASPPRKSHRNSSAVSPRRGHHGSLGTSSPRQTHNHSPTAAQHRRTLDSSGTQHLRRAHHESPDLELHKAKSSKAAERAPSKAASQSGLGPSHPSLSTNSKYEHDSDLSPPRKRQAKAHFEAKKQLDSKGVYQKASDSDLSPPRKKKNSGHQDSDSDLSPPRNRPRRQSSDSDLSPPRRRQRTKSSDSDLSPPRRSPRPGKKTAHMYSGAKTGLVTDVQREHQELKKQDQDTTDLGAQFEFTETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQEREGDPMANFIKKNKAKENKNKKVKPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFARLASKKAVEELAYKWSVEDM
The following text describes a protein:
Function:
Key enzyme for mannitol biosynthesis.
Sequence:
MAETEWTPEALSGRYEEIKSCIPQQLEAYARFLREAAPEDLRRWQQIAQDLKLELNLENGRIKYKKEFKPLELPVDICYIRHGKTQGNTEPRVFQGQVDYANNQLTQQGQQQAAAAATKLEAMAAAKEFIPDLLLSSPLLRAVHTAQPFVDANPKPLFRVLPELAEMAFGEWDNRKVAELEKDDPAHLFYLQQNAVIKAKGPHRICCQLWQSPEWLEGKKELPAENFLECLDRQRKALIKVGEIAKELCGPSCGERKPRVAVYGHSMAGAAVSVLLGFGKEDQLGFLGFDGNYIMPNATPTILIPNAKP
The following text describes a protein:
Function:
Somatostatin inhibits the release of somatotropin.
Subcellular Localization:
Secreted.
Sequence:
LSMQLLASLASLMLVVYSVRAAAVLPGEERATLHTKELSKDRKELILKLISGLLDGADSAMLAGDVASVDLEEPLESRLEERAVYNRLSQLPQRDRKAPCKNFFWKTFTSC
The following text describes a protein:
Function:
Required for the induction of seed dormancy. The level of DOG1 protein in freshly harvested seeds determines the level of seed dormancy. Determines the temperature window for germination by regulating the expression of micropylar endosperm-weakening genes through temperature control of the gibberellins metabolism. Regulates seed dormancy and flowering time through an influence on levels of microRNAs miR156 and miR172. Regulator of seed maturation interfering with abscisic acid signaling components and activating ABI5. In cv. Cvi-1, enhances glucose induction of ABI4.
Miscellaneous:
MISCELLANEOUS: The Columbia and Landsberg erecta alleles have weak dormancy phenotypes, whereas the Cvi-1 allele shows a strong dormancy phenotype. The Cvi-1 allele shows a sugar-supersensitive phenotype, whereas the Columbia and Landsberg erecta alleles don't have a significant effect on sugar sensitivity; MISCELLANEOUS: Transgenic mutant seeds expressing single DOG1 transcript variants lack dormancy and do not accumulate DOG1 protein. Simultaneous expression of two or more DOG1 transcript variants encoding different isoforms, however, leads to the accumulation of DOG1 protein and increased seed dormancy. The spliceosome disassembly factor STIP1/NTR1 is required for proper transcript levels and splicing of DOG1; MISCELLANEOUS: [Isoform 2]: The use of a proximal polyadenylation site leads to the production of a short DOG1 mRNA that is translated in vivo, producing an isoform that is sufficient for seed dormancy establishment; MISCELLANEOUS: [Isoform 2]: Produced by alternative polyadenylation.
Subcellular Localization:
[Isoform 1]: Nucleus; [Isoform 2]: Nucleus.
Sequence:
MGSSSKNIEQAQDSYLEWMSLQSQRIPELKQLLAQRRSHGDEDNDNKLRKLTGKIIGDFKNYAAKRADLAHRCSSNYYAPTWNSPLENALIWMGGCRPSSFFRLVYALCGSQTEIRVTQFLRNIDGYESSGGGGGASLSDLSAEQLAKINVLHVKIIDEEEKMTKKVSSLQEDAADIPIATVAYEMENVGEPNVVVDQALDKQEEAMARLLVEADNLRVDTLAKILGILSPVQGADFLLAGKKLHLSMHEWGTMRDRRRRDCMVDTEVIFDACTTVNSGPRPTETTNNERN
The following text describes a protein:
Function:
Component of the crb-galla-Xpd (CGX) complex which is essential for proper mitotic chromosome segregation in early embryos. The CGX complex is also required for cell proliferation in developing wing disks. In the CGX complex, acts with crb to recruit Xpd thus forming the functional complex.
Miscellaneous:
MISCELLANEOUS: The name 'galla' means splitting in Korean and is derived from its role in chromosome segregation.
Subcellular Localization:
Apical cell membrane. Cytoplasm, cytoskeleton, spindle. Note=Expressed in a punctate pattern in spindle microtubules during metaphase.
Sequence:
MLSYIKRKLSESDSGVSSVATVTSSCGGDSGRAGGTGSSESGTGSSSASISGRSQNADELVRKTSQMSMDDEAIAFGEDALLHELGYKNQTELQETIYDLLRGIRDPEKPCTLEDLNVVYEDGIFVMPPTRSNVSVVRIEFNPTVPHCSLATLIGLCIRVKVERGLPHNIKLDIYIKKGAHQTEEEINKQINDKERIAAAMENPNLRDLVENCIKDEE