lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Sequence:
MKKITPKAMCAWIPKREDETHKGDYGRVLIVAGNKQFGGAAIMAAEACVKSGAGLTTVASDSVNRPALQTRIPECMFIDYENITSLSEQISQFDTILIGPGLGLDAYAEEIFRLVLQKSTEHQQVIIDGDGITIYAKGENPHPAAKLTFTPHAGEWERLKVLAPDAVTPTDVALAIDATIVLKGHRTKVYSGESAWQNMYGTPAMATGGMGDTLAGTICGLMAQTEKPITGTLAAVFLHSYIGEILAKKRYVVLPTEIAEELPTYLKIFSETDEHA
The following text describes a protein:
Function:
Membrane-bound protein expressed on myeloid cells which acts as a ligand to stimulate the activating receptor NKp80/KLRF1, expressed on the surface of natural killer (NK) cells. In turn, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Golgi apparatus membrane. Note=Resting NK cells contain intracellular stores of CLEC2B associated with the Golgi complex.
Sequence:
MMTKHKKCFIIVGVLITTNIITLIVKLTRDSQSLCPYDWIGFQNKCYYFSKEEGDWNSSKYNCSTQHADLTIIDNIEEMNFLRRYKCSSDHWIGLKMAKNRTGQWVDGATFTKSFGMRGSEGCAYLSDDGAATARCYTERKWICRKRIH
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MADEGKKEEPIAVGDESMEIATETPTGGALTLDDSHATDLATLPMGQDEVSERLESLHKTDMKIAKMTETLSNAIDLLIPRSELDINSFELKEGDKGWEPGIQQGLPSLKSAFKVNSIEFLQSLEEVSTTLRKEIKRLNDFSRDKVLPINTDTKAQWTSLENYDKIINQIKGMLGAEDKDKEMKDV
The following text describes a protein:
Function:
Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (By similarity). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (By similarity). In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity). Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Domain:
The fido domain mediates the adenylyltransferase activity.
Sequence:
MILMPMASVVAVAEPKWVSVWGRFLWMALLSMALGSLLALLLPLGVVEEHCLAVLRGFHLLRSKLDRAQPVVPKCTSLCTELSVSSRDAGLLTVKTTASPAGKLEAKAALNQALEMKRQGKRGKAHKLFLHALKMDPGFVDALNEFGIFSEEDKDIIQADYLYTRALTISPFHEKALVNRDRTLPLVEEIDQRYFSVIDSKVKKVMSIPKGSSALRRVMEETYYHHIYHTVAIEGNTLTLSEIRHILETRYAVPGKSLEEQNEVIGMHAAMKYINTTLVSRIGSVTMDDMLEIHRRVLGYVDPVEAGRFRRTQVLVGHHIPPHPRDVEKQMQEFTQWLNSEDAMNLHPVEFAALAHYKLVYIHPFIDGNGRTSRLLMNLILMQAGYPPITIRKEQRSEYYHVLEVANEGDVRPFIRFIAKCTEVTLDTLLLATTEYSVALPEAQPNHSGFKETLPVRP
The following text describes a protein:
Function:
RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.
Sequence:
MATQSVRTKRKSKWDQRAPNVNDKANLTTENKADDNPPSTVNEEDKAAVAKAAAARLNAILAAKGKIIKSEPPPALAKPTTTSSVTNTSTSSTSDNNGSNQASKSSQPAVITAEIEINDLISRTILCKGLTQDDINRQSGAAVSTKGRYISPSEKLGIDLTVDRPLYLHIQAAAKENIHTAARIILAKIAKIDPATKPEVKYTPADAAPSSTNVTTTTVPLPTGLHYVQDKVFVGLNDAPAQFNLKEKLQGSNGSFFLHIIKETGAKVQLRGKGSGYIEPTSGKEAFEPLHIYVNHGTYEGLESAKKLCQNLVDTVKQQYKQFEESQAKAQVPITYQSPYPTPNTNYFASGYPPPSPVPYQNMYGYPMYGQQQVPPALPPHMVSPNPYASPYGQFANYGQSNQYQGNMYNNYYGYPMATYTQNEIPQVSPSTTVNQEEPPAKKLKNEEPNSSSIAEDSSELPQDIEKMPNLPDYTNTLNAIGKDEISQKVGNKAIDVPDPFGLLGTGKSNSKPKSSRQNTETSAMKDRDLMPPPAFLPVSNPIAPGNTKIQASNGFKSTTKQKNSTGESSKSGLLSLASYGSDSDEESSDSASAPDGNRLPFWAAHDYKKATE
The following text describes a protein:
Function:
May play a role in preadipocyte differentiation and adipogenesis.
Subcellular Localization:
Cytoplasm. Note=Diffuse distribution with some highly concentrated spots around the nucleus.
Sequence:
MSSPEIASLSWGQMKVQGSTKIYKDCKVWPGGSRDWDWRETGTEHSPGVQPADVEEVVEKGVQILVIGRGMSEALKVPPSTVEYLKKKGIDVRVLQTEQAVKEYNALATQGIRVGGVFHSTC
The following text describes a protein:
Function:
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MRDRLFSIIYKYNLHPNRDLGQNFLIVPDIIERNIERAEVGEKDTVLEIGPGLGVLTDPLSKRAGKVYAIEKDCRIVEILRREYNWPNVEIIEGDALKVEWPEFNKMVSNLPYQISSPVTFKLLSREFERAVLIFQLEFAERMVAKPGDKNYSRLSLMVRAKARAELVERIGKGAFWPRPKVDSAVVVLEPKPPEERIDLNENLVKALFQHRRSTVSAALKKSAHMLGLSKDKARELRQVFSRVPHSERRVFQLSPEDVLEIEEFLKKEGVIESYPASP
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B. Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53. Catalyzes monoubiquitinates the translesion DNA polymerase POLH. Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation.
Subcellular Localization:
Cytoplasm. Nucleus speckle.
Sequence:
MAATAQEDGVRSPAPGPRGCEHYDRACLLKAQQTCEDCSTLFGEYYCSICHLFDKDKKQYHCESCGICRIGPKEDFFHCLKCNLCLAMTLRGKHKCIENVSRQNCPICLEDIHTSRVVAHVLPCGHLLHRTCYEEMLKEGYRCPLCMHSALDMTRYWRQLDIEVAQTPMPSEYQNVTVDILCNDCNGRSTVQFHILGMKCKLCDSYNTAQAGGRTVSMDEQ
The following text describes a protein:
Function:
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.
Subcellular Localization:
Cytoplasm. Mitochondrion. Note=Relocalizes to mitochondria after H(2)O(2) exposure.
Sequence:
MTGEITILYGSETGNAEEYAKYLKQRLRSYNLKPINLASLDDYPLKRLVTHTSYLIIICSTTGQGEIPRNGKKFMKFILKKKLPSDLFQHLQLTTFGVGDSSYVKYNYAIKKIHTRLMQLGCQLLSPRCEADEISPEGVDGYYIEWEAELIAALLNKFPSASKISSEAVPMPEYRISVSKSDTTIDPKEVIDNPIVSRLGKDGLKLGTVLENNRLTSSNHFQDVRDFKFSSNGLNYLPGDTVSLFPCNFDEDVDALLQSQPQWLKIADKPLNLKNFPHLEGGFADILTLRTLFKYHLDIMSIPRRSFFALLWHFVDPSTEDGEREQEKLKEFGSLDEPEELYDYANRPRRSILETLLEFENNLTIPVSYILDLFPLIRPRMFSIASCPSSKEVELVVAIVEYKTIIRKIRRGVCTRWLKNLKPGDQFLFSIQRSSFKYKDDNSPIIMVAPGTGIAPMKSLIDEVIQNNSKQELYLFFGCRFKEKDNLIESFWHGNENQNLHLVSAYSRDSNSKYRYVQDALFAHSELIGKLLIEQNAKVFVCGSSGKMPREVKITFVEIVKKFTGMDEGDAQKYIIGLEDNGRYKEDAW
The following text describes a protein:
Function:
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm. Nucleus, nucleolus.
Domain:
The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide; The HIT domain is required for enzymatic activity; The C2H2-type zinc finger mediates DNA-binding.
Sequence:
MRILYRLLKMADDTVKCYLECCKSSHPKLPLPHNVPVIIGRTPELGITDKLCSRSQLELTSNCYKRYVLVKRLGANTSQINGIDIEKNKSSRLEEGQDLHVVNGKFPHRVYFTGCQNDTKTEKAVVPKLPTKSTDLTKSDLSIKQPERKKLKVSENKSKVLNSKIKPQEKFSSESVYAFDSPSPMSSRCEKKAESNKRAPTHKHWSQGLKASMEDPELVVKEDEQIVVIKDKYPKAKYHWLILPKDSISSTKNLSTDNIELLKHILKVGQELAAEVKDKQPDVEFRFGYHAVASMSQMHMHVISQDFQSSSFKTKKHWNSFTTDYFVDATDIINELETGGKVKDRRTMTSLLNEPLKCHRCKKPQKNIPTLKKHIDSCQK
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
MESLNVWSHLIALLLYLLSLEHFCFQASGKDGIPSYSSSSISSSGDATSNIKGEADGISSIKGEADKESVGVQNIYNPPTSNYNYYYPGYNGPFPQLDDHGYFQADGSHVGMQSDNGSVVYYLPGYNPYASGALIGVEGQSIGQQPYFSSSGYLQHPVSYGSAAVPCYSWDSTYAGDVSNGSAAFGNGKYGSAKSNGLNSMKSNGNIGGKSSKSNYMQPNRPLNKVSPLGSDFSAGLMKGYHHVGNFSSFSAHKQGPLSHNGTMNYRQNGRMWNGNDRNRPRDKFYKTNDFEASSELTCGPRASNKISPLDSSAKEDLAFTVCRDQYNQADFKTEYKNAKFYVIKSYNEDDIHKSIKYAVWASTPNGNKKLDAAFCEAEQRSSETGTKCPIFLFFSVNGSGQFVGLAEMVGQVDFEKDMDFWQLDKWSGFFPVKWHVIKDIPNNQLRHIILENNDKRPVTFSRDTQEIGFEQGLEMLNIFKGYSSKASLLDDFNFYENRETSVDRKSNKLATLRMEINNNGDFPKHPKSGERKHEEESWTKKTSNPSSLINLTKNLSLNGYSQKSNSIKKPIENSIPAAASP
The following text describes a protein:
Function:
Proton motive force-driven secondary transporter that mediates the transport of citrate complexed to Mg(2+). Cotransports at least two protons per Mg(2+)-citrate complex. Can also transport citrate in complex with Ni(2+), Mn(2+), Co(2+), and Zn(2+).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFTEVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGTAVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGATPRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEPAAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQRQRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVALTSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHLLVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV
The following text describes a protein:
Function:
Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein (By similarity).
Subcellular Localization:
Nucleus. Note=Redistributes to discrete nuclear foci upon DNA damage. Interacts with CEP164 (via N-terminus) (By similarity).
Domain:
The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.
Sequence:
MAGTPAPNSHRKQSGGLEPFPGLSRSIENPPSKRARSFSETTVPDPEDPFGEHAEFTADDLEELDILASQALSQCPVAPRNLSSAHKVRRLDGLPNSPIRKSREDIPVKDNFELEVLQIQYKELKEKLKAMEEEILIKNGEIKILRDSLRQTESVLEEQKRSHFLLEQEKTQALSEKEKEFSRKLQSLQSELQFKDAEMNELRTKSQSNGRTNKPAAPSVSHVSPRKGSSVVLKSEACSPHVGKTTFPTKESFSANTPLFHPCQTEAGHRFLVGQEVSDNKNHSLGGSLMKQDVQQRILADGWMQRKDAQGSILINLLLKQPLVPGSSLGLCHLLSSCPEVPTGTLLQPPGLSTLPGTSGLRTISSSDGPFSPSALREAQNLAFTGLNLVARTESSHDGDMAGRRVFPLHQLPGAVHLLPLVQFFVGLHCQALQDLAPAKKSGVPGDSATHTSCMSSGVEASPEDSIHGLESFSVASLSVLQNLVCHSGAVVCLLLSGMGTEAAAREGNLVQTCADTTSASREDAHDQDQHPLLKMLLQLMASSSAASGHFQASVLGLCLKVLVKLAENASSDLLPRFSCVFPVLPQCLGSALPLPCVLLAVELLSVLLDHDSLAWQLCSHPEGCLLLRLYMYITSRPDRTASETQWLQLEQEVVWLLAKLSVQSPAPAGIGSDCHCNVEAVRALTVMLHRQWLTVRRAGGPRTHQQKQTIRCLRDTVLLLHSLSQKDKLFTVHCVEVLHQYDQVMPGVSMLIRALPDVTDCEEAALDDLCAAETDLEDSEMDCN
The following text describes a protein:
Function:
Involved in the biosynthesis of alanine.
Subcellular Localization:
Cytoplasm.
Sequence:
MTFSLFGDKFTRHSGITLLMEDLNDGLRTPGAIMLGGGNPAQIPEMQDYFQTLLTDMLESGKATDALCNYDGPQGKTELLTLLAGMLREKLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRADGRVKKVLFPLAPEYIGYADAGLEEDLFVSARPNIELLPEGQFKYHVDFEHLHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYGVPFPGIIFSEARPLWNPNIVLCMSLSKLGLPGSRCGIIIANEKIITAITNMNGIISLAPGGIGPAMMCEMIKRNDLLRLSETVIKPFYYQRVQETIAIIRRYLPENRCLIHKPEGAIFLWLWFKDLPITTKQLYQRLKARGVLMVPGHNFFPGLDKPWPHTHQCMRMNYVPEPEKIEAGVKILAEEIERAWAESH
The following text describes a protein:
Function:
May regulate adipocyte lipolysis and liver lipid accumulation.
Subcellular Localization:
Secreted.
Sequence:
MVILLGVLSRYMFLTKRQAENRNRDDEEEDVFGDFWESHPEGTQLIYKPSALANWLLRDLQRQSLLQSTDWWMRKWPHIQTIIQNLLPADKILELARDHLQLADGGIVALDWVVGPRGISGTRRGTNTAGSPPLLFIIPNPFGKLTKNTEQFXLRALEKGFYPVIFNRRGQNGCPLVTVKLQAFGEPADLKEAVSYVRFRHPSSLLFLISEGLGSGLLLSYLGECGSSSYITAASCISPVFRCQEWFETGLPWLYDCLLLLYQKFHLSRYSTALADVFPMERVLKSSSLQELHQVLFCQCKGENISWDEYWEHNDPLRDVDEVAVPVMCICSTDDPIRGPAEKTLPIELFRTNPYFFLSLTHYGGHCGFLTKSDVSWSHKVTLDYFSSITEFFQIEEKASVLPRGRSSVTINRRRRGTLQRRDRSVTDLHEMFSWKRSYTR
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEKHKGYMRGGFRVLAVIVILLNIVIMSVAAQEEEEVATAAVVKVKVGAVLDLNFSFGKMGLSCISMALADFYSSRSRYKTRVILNTIDSNNTVVGAAAAALDLIKKEEVQSIIGPTSSMQASFMIDVGDKAQVPIISFSATRPSLTSHRSSYFFRITQADSFQVKAIAAIVKAFKWRKVVPIYVDNEFGDGIIPFLVDALQEVDANVPYQSVISLTATDDEIELKLSNLMNMQTRVFVKFDVVVGDITIRANRSEYIDYTLPFTESGVAMVVPMNSSKNTSVWAFLKPLSWKLWVVIGNSFLLMAGIVWALEHRVNEEFNGSVVNQICNSLWYSFSTMVFAHLKIKFIFVTPFLIWCFSGQGFPVGSPLVPDVSRAILKVTEGDRIREIENAWFKKVKECSSSEAAELSSSRLTIDSLWVLFAITDGVSILLVFCYVVYFVLKELPQSWSAKRPSIWQTWTHLFSRFMATDNEAINRRKRGSCPCHQD
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
MELDSVKQQQQQNACCEYILPIKKRRCKMLVKKGNRFCGEHSIHDQNNTDRMVCPNDGKHTILKADLEIHLTRCNSRIRDAEYIKIDANSIRGETKRTDKIDRRATEDEICTTVHKIWKCYETDVMDRLIVEQQRNELVEQNIAQNSDLNNTKKKQLYQISSILGHIESTGLLPTCSKSCMFELGAGKGQLAYWISKAAPNGNYILMDRSGSRNKFDTAAFRENPNLSMKRFRCSIEHMDLSKIDELKNSEKILAICKHFCGSATDAGIRSLMNSGLQFNAALLIPCCHHKSRFAEYGGHDFLEKWEMNDEASFAALRYIASFATNGAVDTEATEGWKSIHPPLELGRRAKAILEIGRAIWLESVGFKTRVVEYVPPEVSPENLLILALK
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MLRGRESLIRLVGKRQRNVSLPARDELECGDFSLEIKGGLSLACCDWVECPVCGKQIRGNELLVNCHLDTCLQSGKKKKNSVQHTLFHFNLSKKIEYEESGNCVLEIQQSPLLETAVDCNPAAGSPKPEVSSTLEEPDVANSVLPAELNSETRDLYNGCLEARIAGRKYHRDVECQAGMRVHLVREPENPMDTYAVKVLTADGLSLGHIPKELSRYLSPLMDKGVVDVQGYVSESTSEAARLKLDLREIQSRTIGSLSEEKVLAVKWSRLMDAADKGQDHGCRYQQNFLYMLQVVLERDLHLFTPDEIELLEAFRSISSDGQRRFVRLAQRKGPWFRLQNIFYEDIGDTNSAVHELVDQKCYAKFEKDSAITAIRDALISLHFNLTALIREATGPCIRIAETVDVLLWRLQRLFFLNGEQEFDVFLLVDIGRINYPSYRCARTMPVFASREDFLAYEQRLEESLLVAENGLNDFNVRGGDRIALQRRVLRLGKPPRRWKVPPYAALLKKKHKVVTIMGRPLNNANGMKSRFYGYDGQQCRVEDLALQYYAGEDGGGWKGVHSESGIWLTLFGLLMWDVIFSDVPDVFQTPFQTAPLDLCTDSFYPVRSSLIESRLQAIRDGGARQLVAETWEEHYGTSCSGVNWKKYSLEDLQTITVCIGGPGLSAICKLLAEDHSNWTAGMPDLLLWKEKEAKLAEVKGPGDRLSEQQVAWFLILSDANVPVELCKDEPNTGGFECRALGPKLYLLAIRHSHNWWHLELCHLEGGPAENVLRIFDTRICGDRERAERDTFAIWRSHHEAHHPHIRLSISFPAVENAALVLRSSIDSCVHRRCSPKSSVEPIAYALMRIRIALALYKYGSSNESAVSSLLGSNFSARELKVIGALNEQIEYLDICGQQQAHI
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Responsible for the transfer of the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MIVGLTLYFVLFRSIQYLLVFLTPIRQFDTSTSLLLNELCSSPSEINSYWNKYFWNKLLSWDSVFFIKNITSKNGKPQFEHEYAFSQLWTFFVRLFIKSNNDSIYHALRVGVAIENVLFYLSGIVLYFLTKKIFSQNIRQSQFARTIAKKTSLLFFLTSAAGFLTSIYSEPLSFFFAFVGIWSRECSISVPVLGQFDISWRYWFPYSFISMACFTLASLNRSNCVLLGIYFIFDLIELTKNRKFVKAICFPLLSGSLMFSALLYQQYYLPYKTFCPQRGEWCKSQLFSSIFITKTSLYSYIQSHYWGVGLLKYWTPNNIPNFLFAVPNIIILIYSSIYFSKIYPSYNLKALVWITRALVVIVCFFAHVQILNRIASFLPLHLWYLADRLVKTSDPKKMENPKGDDKIVKFYIYWLAFWIPLQTILFAAFLPPA
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MRRDRPVQRRPPLGGYLSQDMQRLEERAWSLICGEEWGVFGGICRTLNIMDAPPGTGLMGLGRRPETEEKFERETRMSLFGALQHSRTTDLDVRLDLPPVPSNADLTGLSIRVPLCLDQSDDEGFQSASNLTPDSQSETSPSPEVDVWEALRTFVPGRRRCWENIGCPPGQKEPPYLTEAGREAFDQLYRLWEGEMRNILSTQTPSPLLPLPLDCQSQLVKDVLNVLIGVSSVTFPLNEASVQFDVRPDICVSGTSPESVSRLLSELAQYGTHYLRLSRFSLSGGSQKGLVFQAFTGGLRRYLHYYRACVLSTPASLSLLTIGCHFRKLGRQLRYLSELCCVDGIAGVGRATFPVGVKLLSCLYNEAQSNCSNENHPVLLSLLKSSCEPYTRFVSDWVYSGVFRDVYKEFMIEVNEDYLTYRDKNFWTQGYTLISRDAEDCVPVFLKHIANDVYVCGKTINLLKICCPQHYIFWSDIPVPRIAVTFSLQEVEEIERDCAVYRGRMETISRHSAISREEQATRTEQARQELINQVRESAAKTLERIRGRQVSQRLAEEAQKRERFKEMKQQLELDQEWRSTARRKEQEDDFSYARELRDREQRLQALEEQLERQARMDLIAQYSQLSEAAARRELRAMWKVQRMKLDEQRVSFLQKEQHNIQALLEMKFSLGKDDPLLETPHIHQPKQLLTEQQNLSEPQTGHPPVPESSASPCPPAISQAVISEGIDTADFLPKPPHSPKSGAVTQALHDIGSDLLPISQAPNPSVPHPSASHIQLGEHVSEVLESFPLPSEFGQASNSSFPLGQFIPEGLVGQPKASVHGHPSQSFVQLGDSTASGRIMGPVHSESNTSTQTTQESTCEAESESRCTEKQATGTEPSAASAGSEPKQATQEPADEAKSCESVSQTSHCSQPEQEQSVSPLISFHESQSDTLMRNNTADQDPALIASLSSSDVHSHASDANIRVGEHVSEVATPLFTSDIHGHISDAYIRLGEHVSEVTTSLPTPNIHGHASDTHTRVGQNISEVTTSIPTPNIHGHASDAHKRVGEHISEVTTPIPTANIHGHASDAHIRVGEHVSEVTTHIPTANIHGHASDAHIRVGEHVSEVTTHVPTANIHGHASDAHIRVGEHVSEVTTHIPTANIHGHASDAHIRVGEHVSEVATHIPTANIHGHASDAHIRLGEHVSEVTTHIPTANIHGHASDAHIRVGEHVSEVTTHIPTANIHGHASDAHIRVGEHVSEVTTTTPTANIHGHASDAHIRVGEFVSDVASSRPRWSKYGHSSDSTLKMGCVIPNATHMPTLLPGSAFGHASDSTLTAGCVVSGVNPQPSPIPGSEYGHSSQSSLGIGCVVSGIESTRPSSLYSSAYGHSSDSALGMGCVVGGMVPGSLYGDQQPANSEKASQDTENPADIDTHAPPTDLFSLDEGLAAWALGLGLSPRESPEDHYLLSLACQYQVEHYQDSYSLMTAAPDSEPLLQVTRGPNGLSMEPSLHHATDATAVQQSEMMPLPVLMKHSVTTPLITHVSMVNKAVVDYFFVELAVEKHFQTLRHFLLMEDGEFALSLSDQLFEKLGSGQTPGELLTPLVLNSILNKALQYSVHGDSELAAHFTFALRYLPEIFHPHAPDSLNCLELRYKVDWPVNIVITESCLNKYNRLFSFLLQLKHMVWTLRDVWFHLKRTALVKGAGRSAQFHQLQLYRHEMQHFVKVIQGYIANQILQVSWSEFTHKLSSASDLDAIHRTHAEYLNRAIFRGLLTEKAAPVMNIIHSIFSLILKFRGQLVAQRWELQQGEPVHPGFIAMQQSYNTFKYYSRFLFKVVSKLVDKGYQPHLEDFLLRINLNNYYKDS
The following text describes a protein:
Function:
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Nucleus.
Sequence:
MASSSLAQKTWELSNNMQEVQSIGEIYKYKKQQQQQEILAAKPWTKDHHYFKYCKVSALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVTYFKSSLDRNLLELLWNKYWVNTLSSSSLLTISKPPACKTTIEAIHGLMSQVIKDKLFNQINTS
The following text describes a protein:
Function:
ATP-dependent protein-folding chaperone for the eIF2 complex (By similarity). Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MEKHDIKYFENKKQCQFQEWYEKFKSVTFSSIVIPLPKIFIDYLQSDQFTTPHEGFPEFKVDEHDDLFDDNNWSTSKNHISTLDPKYYQGYSDEEDESSDDDDSNDNDKDKKPKRIVNETEFKELSNQIIKSIEKLGGNIFPKLNWSSPKDASWMNVYNSLKCTNTTDIYLLLKSSDFINHDLMQFSINQDDKDDSLTPYVLVLRKWQNLQPSMEFRCFVKDNQLLGISQRDISTYFKFLKDKKQKIQDAIVKFYNESICGKFSNNSFTFDCYVTKDEQVWLIDFNPIHPSTEALLFVWDELIPELIEQDQDEKENEETKQAKEELPIEPLTKLEFRIIDDESGIKPNLAMTSRLPLDLLQSSGGTGQGNINDILLNFKNQNLN
The following text describes a protein:
Function:
Acetylates the N-terminal alanine of ribosomal protein bS18.
Subcellular Localization:
Cytoplasm.
Sequence:
MNTISILSTTDLPAAWQIEQRAHAFPWSEKTFFGNQGERYLNLKLTADDRMAAFAITQVVLDEATLFNIAVDPDFQRRGLGRMLLEHLIDELETRGVVTLWLEVRASNAAAIALYESLGFNEATIRRNYYPTAQGHEDAIIMALPISM
The following text describes a protein:
Function:
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
Sequence:
MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLLEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEVRENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQDDFLLDESECRVVKSTSYTKIASSSRRSTTKSPGPSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRSSQHGGSSTSLASTKVCSSMDENDGPGEGEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFNTGPKPNSTAAGVSVIALDHGFTIKRSGSLDYYQQPGMYWIRPPLLIRRGRFSDEDATRM
The following text describes a protein:
Function:
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
Sequence:
MYYFIYRSTGSSVYSAVTEILEKSGYWQCKNPDSSKFHLVFGERNRLSFARLGHEPGFTQAVNYFNGNDSICKKSSLVCTLKDYAKKCERNFDWILPAYVVNPEKIRKEIKFHSKRLKENLKSPWMEFYLEKPVRDFREDLRRASATLASGNQRIWIAKPNTGCKGEGIMISDDIDQLIQFVDNSNQSHVIQKYVENPMLLTGERKFDIRCWVLLDHKYDIYLYREGVVRTASDAYDPSNLDKVTSHLTNHCLQQQLADKFGEYEEGNEMFYEEFNRFLEAKYNLSLESDILPQIRRIIKDCFAAGKEKMDASGLSYKSFQLFGFDFIIDDKGHVYLLEINGAPACAECARQLPSFGCGVEYV
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MITLEMMPPLMFGGLVLAMLIGFPVAFTLAAVGLSFGFLAIHLGFFDLNFLQAIPGRVFGSVLSNELLLAIPFFTFMGAILERCGLAEDMLDSMGQLFGPIRGGLGYSVIIVGFILGAITGTVAAQVIAMALISMPVMIRYGYNMRYITGVLAASGTITQLVPPSLVLIVLADQLGKSVGDMYLGAWGPSVFQIMLFAGYTFILGLIKPGHVPPVPKEARTLTGWPLWKKCLMGIIPSAVLIFVVLGTMMMGLATPTEAGAMGAVGAIVLAAIHHKDFTSTDRKILITGVIAAGVGTIVAMMMSENLIFKLAFALTYLAVAWICIRAARIPDLRDLITQGYQSTMRLTCMVTFILIGSTCFSVVFLGVSGGVWLEHLLTSLPGGVWGFLIFINLFIFFLAFFLDFFEIAFIILPMIAPIAQKILAPVVGPDAALIWFGVMLCVNMQTSFLHPPFGFALFYLRGVAPKEVKSSDIYWGAMPWIGLQLIMVMLVIIFPITVTGLLDKPLNVDLDKVKIEVPQIELPPLDLGPPQK