lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (By similarity). May act as a tumor suppressor. Involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (By similarity). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (By similarity). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (By similarity). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (By similarity). Probably represses transcription from ACKR3, FGFBP1 and EFNA1 (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The BTB domain inhibits the binding to a single consensus binding site, but mediates cooperative binding to multiple binding sites.
Sequence:
MTFPEADILLKSGECAGQTMLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLTDSVEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGSGGGGYAPYGRPGRGLRAATPVIQACYSSPAGPPPPPAAEPPSGPDAAVNTHCAELYASGPGPAASLCAPERRCSPLCGLDLSKKSPPGSSVPERPLSERELPPRPDSPPGAGPAVYKEPSLALPPLPPLPFQKLEEAVPTPDPFRGSGGSPGPEPPGRPDGSSLLYRWMKHEPGLGSYGDELVRDRGSPGERLEERGGDPAASPGGPPLGLVPPPRYPGSLDGPGTGADGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVTGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDSRTIDRFSPT
The following text describes a protein:
Function:
Required for vacuolar protein sorting. Component of the retromer-mediated endosome-to-Golgi retrograde pathway. Required for efficient cargo export from the endosome, promoting VPS1-mediated fission of retromer-coated tubules that bud from the endosome.
Miscellaneous:
MISCELLANEOUS: Present with 2210 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes throughout the endosomal system binding to phosphatidylinositol 3-phosphate (PtdIns3P). Enriched on retromer SNX-BAR-decorated endosomes.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate, which is necessary for peripheral membrane localization.
Sequence:
MDNYEGSDPWNTSSNAWTKDDDHVVSTTNSEPSLNGISGEFNTLNFSTPLDTNEEDTGFLPTNDVLEESIWDDSRNPLGATGMSQTPNIAANETVIDKNDARDQNIEESEADLLDWTNNVRKTYRPLDADIIIIEEIPEREGLLFKHANYLVKHLIALPSTSPSEERTVVRRYSDFLWLREILLKRYPFRMIPELPPKRIGSQNADQLFLKKRRIGLSRFINLVMKHPKLSNDDLVLTFLTVRTDLTSWRKQATYDTSNEFADKKISQEFMKMWKKEFAEQWNQAASCIDTSMELWYRITLLLERHEKRIMQMVHERNFFETLVDNFSEVTPKLYPVQQNDTILDINNNLSIIKKHLETTSSICKQETEEISGTLSPKFKIFTDILLSLRSLFERYKIMAANNVVELQRHVELNKEKLESMKGKPDVSGAEYDRIKKIIQKDRRSIIEQSNRAWLIRQCILEEFTIFQETQFLITRAFQDWAKLNSNHAGLKLNEWEKLVTSIMDMPISRE
The following text describes a protein:
Function:
3'-5' RNA exonuclease that trims the 3' end of oligo(U) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. In a second step acts as a cyclic phosphodiesterase that hydrolyzes a U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate to a U6 snRNA 3'-end-terminated with a 3' phosphate. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation. Could be involved in aerobic respiration.
Miscellaneous:
MISCELLANEOUS: Present with 486 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Mitochondrion.
Sequence:
MEFISADYSSSDGSDTESESSNKSEVQIEYTEKTCIQKADSTDLPAIPDSIILKYHIPPNLQKYEHQDMNMSRFWRSFTYFEWRPTPAIHRQLQKIICKYKETFMKQEYTNPYQLVDFDPLFISHLGAPKPLHVSLTRSLLFETEEQRHVFIQEMRNGLRNNEITPFKLQICSYPKLYISERANTLYLGLPVSECPNKAQISPFKTIIAEALQKSGISNYQDLIVSRQNLHVSIAIASNPSKATLKRYQQLNETMGALLLLNNDFAYKLEFLVNSIYCDENRHSIRIPFN
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MSRASVGLASSCLSLKHARFAGLNLGGGLRVRAYAKPRVSCVAYERGEEVDKTRSKKKNVSDFGPSLARGRRLPLLQFETSQQDSNILQETQWARKKAELEFGTQVDGALAESIIRSEYDQRSCNAFIETNLLNAKEVVEKLVKEDGTVKKHLKFAELDRESFTRVFEVAAVRVPADWCGVFVPSLQGHLLNWPRVKNVPRVEGDDGDAALKSLLWKDEQALQTTQGLVESVISAVYPEEPDLDGEQADKIKNKRRLPSLRKLTRGVDSALVQSIKSPKRGLSEQPLVRGREEGAVSVKIVGECQNSQNHDNEPRDAWRLLLLDERYNDTPNDELPQAVQAVLAHPGCELVRCELTLTYDYWPMDEILKEVLPPGMTTPTAFETVGHIAHLNLRNEHIPYRHAIAQIVLEKNKPRIRTVVNKTDVIHNKYRTMQLELLAGNSSLITTVVEHGLSFRLDLASVYWNSRLATERQRLIDTFNENDIVCDMFAGVGPIAIVASKKVKFVYANDLNPAATTYMHHNLRLNKLAYKVEVSNDDARQFVRNLLARNPPVLFTQVVMNLPLDAAEFLDVFVHAFSRDVWERHTLPHIHVYGFSKAKDPEAEYSERIADVLGEMPHPIHIHRVRLVAPGKYMLCASFRLPANVAFPRGSTIREYA
The following text describes a protein:
Function:
Krueppel is a gap class segmentation protein; May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MENAQERDFHRSLEPDVIINHELSEDEEEVTCVKSRDVHSASNNGHPKTVQPDISIIPISRKPQIKIKLFKKEYSPSKDDTKVQSISRSPRQTVRLVSKDEAERAGDTYTRRKSLPLEKCHICKKFFRRMKTHLLKHEQTNRNPNDPLTCTFCMKGFNTQSNLLIHMRTHTGDKPYVCEVCHKGFAQSCNLVNHVRIHTGERPFKCPHCDRAFTQSGNLNNHIRLHTDEKPFKCHFCDKAFVQSGNLNSHIRNNHKFVDDGANESGSEKVEEYKC
The following text describes a protein:
Function:
Involved in larval development and locomotion.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MLDFPRFSLFLFLLFSSFLFSSFVHAATVFSSSLKTCQSQCEERNLAYPLDSGEVHWTGLAEFNYTTRISSCKHGCEDVDERESKCNVKCAEEGIVTNSCKQGCRAVLVSFLAQAQALLIQTRVNMEVLETAMKLKWEFPETLAEELKEIANADIFWFSQTRPLNGILGWRWTSLPQSSFRNSSLVSEVHVPFEHGEHVEVRLALSYRNQVLVSRTTTYHLPLSKAGTTLEVIGQLQLSDDRVAVCYRTNQPTPKFKLTVMTMDDNTINTEESISRCHLFSNLPRDNCCKASISAIDEHGATTAFVEIKLDFFVNQVEIELVSAASSSRIIFSNGTHLLENEELAQYALGDSATVIPFPLPTDDTITAIAGITDTIIAIGSSKGSLWTFQMSANQTDEDQPSSVIQLKTVGEMDTKITQIEIDHIQRTLYAVQHDKGILRCKLRTMESEESPTCVLIVNNDALNPPKEITLDPVNGHIYSLNVDNKVYRTEMIAFNATGIETVASLQYLKDMSPSNGIFFDVSKFLLYSALQNGSMMTLNPVTDQAHIFKDSGYTDVQNFRIKSDLIYWMKKKCGKTDADENCIFTENLQRSEEDIPNKFTYSSALMSYSFLEEILLKPRIVAVSSIALLTSDKTGRVSWDEANTLPFQAQGSSWRNFTYFLKITAPDITDFEAVEMYTSSTDVKIDVTPGNQYNAQVQVCSDDFCSTPSSTSNTALPDLGGGVPFVFTKKKADDIISIDMLGNLVITDDSVKAVERMQNPHVLDNTTKTVYLAGDHSMGIFKKDLDDATGSPKPFKDGLFVEMMSIMPSRSMILIASSYKITSYRLPTTFDFEYYSCEEPLEDCAEVMGISSDDSTGMVYFLTQSRNGTVILWESDPENRAPRDIATAPSIVPFRRFLIIHDKMILVTKNNHIVQTDKSLKVVNVATELERVDRILPLRYAAISHKIEFTDEIKFMEGSKTDLQWTLSPPLEAGTVIFKVSFFREKMGGQDAPITTIQSDTNFTIPPEVLKEWSSAQRFDVSIQAITPWATAVLNRTGLTAPVKPPTPPTQLKIFATQQKTVDGPRALISFFWGPPLEWNGTPYQYIVNCTKDDGKVITIDSSELKPLVKLFAIDSTNSLIIINDLAHEEPRRETRQVTQPVKLDYQAMAFIGEDLYTVRKEGESAQPFLVQIDTNHIDNTVHKVSIGGDVTRIDAMTSDWVGNRLIFVAGTNLYQLSLEPFLSTSLLNPHKLITLSAATDAKQLAYDPFMNTAYLLTKNGSLFALDMNKNTEANLALTVPCLASQTVTWMMTEFAWNRASSPKIYALTWNGLINVDLAEDFQCNEVRIDWSKFGEKGLKAISSFAIADKLFAFVTSSEMLIYGRDTVTPITIANPPLKQILAVSQSSQPYPERSCFELPSSKGIVFSIVNEGKTGALLEVTKSSSSSACLDVSMPQTQYEIYFTRKNTDKVKHVRSFSDRIHVENGILDKETDYDVTVTWLNRYSPASGVSSSRSFRTGFGYPSAPRDPHAIPVTPDTVYLYWSLPETLNAPISEIKYKISQQAAGISVPTSIAVIPLSETVSSNISSDTTACLINPCRVKIANLRPSNEYKFWVTATHISHLDAATILKDDDAVSSEAVARTLDVPGTLRPDNVTGSSLLLRWNGLEPEHRPTSIAIQYRESGGANNEWQSPTNASFEPDVATELVPVTNLLSATTYDYRFVATYTGTYTIDGKVLAFKEDYLQLIQQARTKAGVPTAPQSVEAKIDTEGWIVTWKEPMSDGGSPITSYAVETRINKTAEWEIAERGLDGWKTWWRPGKSETSSSMSYSSEVSEFRIRAANIEGFGAYAYTEEKKEEKEEEKGGILPYFLGISIILLLAAMILVGCFWLKSRRRQQMKKREAEDERNCIRLDVVANMNFTNSRQTLSPEYESEIRNLPIVDYNDVEIVRHISDCSYGSVHEGIAEEVPLSWEKQVKVAVKQLRPKSANHDFDRMMFMKEAILLNNLDHNIVKELGVCVSPGQGLILLEYMEGGNLLNFLRESAPSEMQASELSTRDLLAISVDIARGMNYLERLPHVHKNLSARKCLLSGRPGVAKLEMGMPRALSKGEINRVDLESMQSVKWMAPEVFKDLMFTSKSDVWAYGVLLYEIFSFGEEPYGSMDSRRVITDVRDGNLTLPVPPYCPSKKICKVMKMCLISDPNKRASFATILKIFETCRDDQQSQDDKRIHFNEGSDNINFNASQDSTSSREPPSPSHRIREFTQISGDLEPPSPSPLNQSFGGFEHPYEGDRPATMWNASGARNSAKNSIGRSMKKDKFRNPIHSMDDLVARSQRPLSIHSEDTESTDFGGATSSMHSPSSSNRTNHYELPMSRLSAAPPIGIVNNAFESSNNSLNMSRSWTGLAGEVNPNPAGASSSGTLPHHANSMVHLRAPTGQPPTRVNRNSSGGTCRSVSQV
The following text describes a protein:
Function:
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Sequence:
MASTRIQNITTHLKAKGESQLPDDHHGNTHMDTNMSSTQKLFQLIPGVQSYDWGIQGASSSRVAQFAAATKELNFKAEDSKPYAELWMGTHPSMPSRIITANGQQADHQYEALSSYLAAHPELIGDKVVAKFSDEKPGCLPFLFKVLSVGKALSIQAHPDKPLGKRLHEQRPDVYKDPNHKPEMAVALTAFRGFCGFRPLQEIVHFIKTVPEFAQLVDLSDDELQKASASDLDPSEIKAILKTIFSNLMNSPASTYEPLAAQLSERFAKSSIEGVPEAERKLVLKLASEFPKDIGIFCTFLLNISTLQPGEALFLQANEPHAYLEGEILECMASSDNVVRAGLTPKLRDTETLVEMCTYQSGSNRGRLSAKHWVKSSPKEVEALLYDPPIEEFSVVTTKLEKAQQVTNAPVDGPSIVLVLDGVIEVNDQQGRLKLERGQLAFVAAGVEIVIQNVGADEVRLARAFVEA
The following text describes a protein:
Function:
Has both endo- and exonuclease activities. Incises double-stranded DNA without obvious specificity via its endonuclease activity and excises the DNA from the 3'-to 5'-end by its exonuclease activity. May have a role in apoptosis.
Miscellaneous:
MISCELLANEOUS: Present with 1460 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MWGILLKSSNKSCSRLWKPILTQYYSMTSTATDSPLKYYDIGLNLTDPMFHGIYNGKQYHPADYVKLLERAAQRHVKNALVTGSSIAESQSAIELVSSVKDLSPLKLYHTIGVHPCCVNEFADASQGDKASASIDNPSMDEAYNESLYAKVISNPSFAQGKLKELYDLMNQQAKPHDTSFRSIGEIGLDYDRFHYSSKEMQKVFFEEQLKISCLNDKLSSYPLFLHMRSACDDFVQILERFIAGFTDERDTFQLQKLGASSSSGFYKFHPDRKLVVHSFTGSAIDLQKLLNLSPNIFIGVNGCSLRTEENLAVVKQIPTERLLLETDAPWCEIKRTHASFQYLAKYQEVRDFEYPAFKSVKKNKLADKLNAEELYMVKGRNEPCNMEQVAIVVSEVKDVDLATLIDTTWKTTCKIFGE
The following text describes a protein:
Function:
Nucleotidyltransferase that catalyzes the formation of cyclic UMP-AMP (2',3'-cUAMP) from ATP and UTP and plays a key role in innate immunity. Acts as a key sensor of double-stranded DNA (dsDNA), the presence of dsDNA in the cytoplasm being a danger signal that triggers the immune responses. Directly binds dsDNA, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cUAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor.
Sequence:
MYCNICKRNDFKNEHGLNIHKAKVHGIRKQHESAHPPRERHTERTATKRSDETKTASRPTASHEGKTHTTNPRGQVHPHTSNDVVRQSAMIVQMEAIQKCPLLGNHFKGPADVHPQRTKTPSGARKPETPKKPHSATKDDHRTKTPGTPHSADTRTPSSTGTDFGGVRPKTPRGARKPDTPKKPHSATKDDHRTKTPGTPHSADTRTPSSTDPFICPICDGKSFKYEGWFIKHMENKHPGCAFGVVAKGREDDKSDQEKRDSWKRREGSVDDRPSSVAPNFADSFNIKTFEKWVTVAEASIIRQKTDTDETIDCMNRFIKMLESTMNGISHFPLKTFKSGSYYDRTKIDYNDEFDFMFFPDMKMEAVFTNCPPGYCKIRKGVTNSKDLDPYLNKDGFLVPGLFKQAMFDLFEKSLSDGTFREGRRTTRQTSKPGSPAYTILYNLGIHGKRPIDVDLVPAIRIECWPKPAKEIKPDWVKKETTERATRCFHAVMKTYPENWPDGDLLWRISFTHAEKELILHANEKEKGCRKDIFRLLKKIKEVMKSRNSNDIDKFCSYHLKMFMLKFFDKEKYFRNEMKVDLLKKAIKKLGESVEHGNIPNYFIPEDNVIVNVLEKERTLIAKELRALLEGNW
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MLQEYYNRKVLFITGCTGFVGKVLLEKTLRCLPNVRCIYVLIRQKKGSSLMERFKREILDSQCFDRLRQIYGGGFEKFINEKIIPIEGDMLKEGLGMAENDKRIIIDNVNIIINCAASVDFNARLDDAIQINVRGPQRFIALAQQIKNLENFIHISTAYVNSDKGGYIEEKIYDPNQENLEQLVSQLLKTPVSILEKNVKDIIGDFPNTYTFTKCIAEKLLVQNRAPNFPLTFVRPSIVGASWKDPTPGWIDSLVASSAIFFFDRFRINKNFKW
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MPPAFFQKPEAALKRAQELIQVGKEQDALDTLHDTIKARRHKQWSQMHEQIMLKHLELCVSLRKPHVAKDALFQYKALTQQVAVESLEKVIVHLLSLAEAKTEEAQKTSIEKVEEIDDLDNADAPENLLLSVVSGAAAQDRMDRTVLSPWLRFLWDSYRNCLELLRNNAQVEQLYHRITRKSFFFCSKYQRRAEFRKLCDLLRTHLAQIQKHQHLAHVVKLSSAESLVLMQETRLCQLDTAIQMELWQEAYRSAEDVHGMMQLSKDKDRRTVKPASYVNYYDKLALVFWKAGNRLFHAAALLQKFIIFKDMKKTFSAEEATEQATRVLLASLAIPDGADLPSDLTRHLDIEDQHLGNIRLLSNLLRLPIAPTRSGILKECARFGVPETASEEVRSLFRLLENNFSPLGMTKQACAVLEKIEKPEYAQYMDAIKAVAATKALKQISVIYEVISWERLLKIIPFYEELEMERFIVDVSKHRFVKAQIDHRGDCVRFGGAAEATLAGGVDLEDADGFTGDDTQLGVEGIRTHLELMYNKLKSTVESLDGQTLREEALETVKRHASIYGMCKQTDYERILMRRRKIETYKESSERVKAEKTAKAAEEAAKREEQKRLEEKKRLEQENINIEKRKREADKREVEEKVRADQMRKLLSTSFGMNILREYGEAAIAEMDIEQVLKEQRERLDKERQQQQQRLQQQERKFDHWVRALHLEEVLERKSIQEKRRRELPIKWKEFETNRVQKAIEEHAREVDVFNKLSAVEEDAEEWIEDVKNSHEDDFNKKMDEWCEKLDAVKAARLAERAEYRRKERRGEWLAKMALEEKRRKEEEERQKQLALEEQRRARRGENMDSRRRERDDRDAESSMAMNDDNWRRGAAPPPSRGMERRGPPREFERAPERTPMRNEPPPSNSDRVDNWRSESRPSQPPPPMAAASAPGERPRLNLTGPPRGPPRDFERGPERTPMRNEPLSNSDRVDNWRSESRPVQPPAPMVAPAPGERPRLNLVSRTRRDEPEAPSRDDFGTRRVVREERRDDGPRRDGPAQSAASEGRWERGATVRRPDPAPAPSAPSASSGQQDDDEKWETAGSKGRAKDAVPTPAASQPWRPRGGDGPRGGDGSRGGDGSRNGAGGDNWRR
The following text describes a protein:
Function:
Probable transcription factor that may be involved in stress responses.
Subcellular Localization:
Nucleus.
Sequence:
MESYKCRVCFKSFVNGKALGGHMRSHMSNSHEEEQRPSQLSYETESDVSSSDPKFAFTSSVLLEDGESESESSRNVINLTRKRSKRTRKLDSFVTKKVKTSQLGYKPESDQEPPHSSASDTTTEEDLAFCLMMLSRDKWKKNKSNKEVVEEIETEEESEGYNKINRATTKGRYKCETCGKVFKSYQALGGHRASHKKNRVSNNKTEQRSETEYDNVVVVAKRIHECPICLRVFASGQALGGHKRSHGVGNLSVNQQRRVHRNESVKQRMIDLNLPAPTEEDEVSVVFQ
The following text describes a protein:
Function:
Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.
Subcellular Localization:
Mitochondrion.
Sequence:
MREIITLSFGQTAGHINADYFNSQEHYFPLATKSTSDPTVRFRRGVATDSRTETYNPRLLTWELKGGYGAFQAFNQFYTEGDKSQPQVWNEGEIKEIKEQPVDKNEYQKALDLGRENASQLNTDTTKRWTDYNRLFHHPKTRHQLDNWLFDPDTAPQGIHRGGDQKWTGFDVGVNEWEHVLNSDKEYLDSTLRSWVEECDSLGGLNVVVDDSAWAGVAAKILANYRDDFDAKGTVVTWSVEAKPEKKTRETQKNAIQTTVALSQVSSIYIPVSFPTKTPIDADFDPTSPWHQAALFGLSVYEPVQLMATQRTGGLSLDAMAALLDTTGERNIVSEVGGTLTDVDGDKSTVQYDSRLFQELFLPSRIPPKTPHVFSDLSIARLEDQDDDANSYRLNQPMPEVSSQPEFTKQFVSSKTRLAVTTKPRRTLLDMAKFVSVYERGDEREEMKQELGDMASKYEHGWEEESDDDDDY
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Plays a critical role in the development of the central nervous system (CNS).
Subcellular Localization:
Nucleus.
Sequence:
MASENPNAQNPGCKIMTFRPTMEEFRDFGKYIAYIESQGAHRAGLAKVIPPEEWKPRKSYDSIDEMVIPAPIMQVVTGQSGLFTQYNIQKKSMTVGEYRKLANSEKYCTPRHQDFEDLERKYWKNLTFVSPIYGADISGSLYDKGIGEWNIGHLNTLLDMVEQECGIVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAKGFFPGSSQGCDAFLRHKMTLISPSILKKYGIPFDRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKMATQCTCRKDMVKISMDVFVRCLQPDRYDQWKQGKDVTALDHLKPTDLTSPELELWWERRAIVTPNTLKGLRTCSKQLIAIVAMRKMKQVRRLKMEDIKALAEVGVMVDPVEHQRMVEAREAEKKEKEAASGDQEEPKHVASSAREGKAAPSQMELPSLLISPAPLDKSQAGRQLPVAEGEKAKKKTEPAVRVQEEGEQSFEARPIIPTLYVMPSPKKVIFDKERMSCQEAFEQFAKSKAAHASPIRRQGHWVKDESSDAEEPGEGRTEKRGIQLRNQSAVELGGNGVFPQKGEDPLSNSTYISFSISKNSLETTLVAEIPLLFNKSLRKNINMLYACKSLPGNLLLNLKLSLLNRLPDNSIGILYLKHQHRWSFVQEKRFGCKQHIGSVRMPNYLSITPLHFMLHLHKKSFFPQFPNKPPMRSPLSVVKQEASSDEGESVGRASPQKDLVSNWARHFKACFQRAHYRKLAETISRLTEGWGGVGMWALETGCHGGLSKSSLVDLLQQTLIDSGIMTFQLPISKALSAGRMEVVRPVLLEAQRLISESDGCKYTALTKCRHTEHTARRPLTLYSTQGQRPLHVLQCSLHCCKTPVSCPVKLQLFSNSLTKVTGVLTTSYGSNDTENCTHVCSSILFTEMSVILLDGGVTTLRPCRASLRHKGSFAHHVFLPPVTDPFICAIINLGLFPTLIKHSSPWNPCLYTASHSFRASPVLGIGRKQILLQIVQMSEELKSCYSEKEELDPEAVKTVLSHLWQNKSHNFLAERRFNAAVALIEPYCAICTLFFPYIQPNKDLSLSADSLTIPVSKCGTYTRPLIPEMCFSSGGENTEPLPANSYIGDDGTSLLISCSKCCLQVHASCYGVRPDHVKEGWTCSRCTANAWTVDCCLCNLRGGALQMTTDKRWVHVICAIAVPEARFVNAVERNPVDISTIPEQRKNLKCVYCYKTMKRVSGACIQCSIDRCSTSFHVTCAHTAGVLMEPDDWPYIVSITCHKHKSTNQNLSQATKEVSLGQTVIGRNRNGLYYKCRVIGTATQNFYEVNFEDGSYSDNLYPENVISRDCLQFGPPVEGEVIQVQWTDGNIFNAKFITAHLMNVYQVEFEDGSQLTVKRSDLHTLEEELPKKVKSRLVRAVNTEVQ
The following text describes a protein:
Function:
Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity).
Subcellular Localization:
[Processed inositol 1,4,5-triphosphate receptor associated 2]: Cytoplasm; Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Note=Colocalized with ITPR3 on the endoplasmic reticulum membrane.
Sequence:
MESTPFSGVANQIHTLCERPTYGEVKDGALDVKRQHKCPGPTSGPSPGTNLSGCIRMNDDPSMEENGVERVCPESLLQSREYSSLPLPRHTSSTDGTITSSDPGLEILNMASCDLDRNSLCKKEEDTRSASPTIEAQGTSPAHDNIAFQDSTSKDKTILNLEAKEEPETIEEHKKEHASGDSVVSPLPVTTVKSVNLRQSENTSANEKEVEAEFLRLSLGFKCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPLCEDDNQAQEIIKKLEKSIKFLSQCAARVASRAEMLGAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQNERSFNPLEDDDDCQIKKRSASLNSKPSSLRRVTIASLPRNIGNAGMVAGMENNDRFSRRSSSWRILGSKQSEHRPSLPRFISTYSWADAEEEKCELKTKDDSEPSGEETVERTRKPSLSEKKNNPSKWDVSSVYDTIASWATNLKSSIRKANKALWLSIAFIVLFAALMSFLTGQLFQKSVDAAPTQQEDSWTSLEHILWPFTRLRHNGPPPV
The following text describes a protein:
Function:
Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.
Sequence:
MLLNGDKQEVEIRGCSIWCVELIRDCLVELLEKRGESPPVEVNAILLDYHLWDYAREHRDGMKGVPFHRTRCIYY
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. Sigma-W controls genes involved in response to cell envelope stress such as antimicrobial peptides , alkaline pH , transport processes and detoxification.
Domain:
The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA , and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. Also mediates interaction with the RNA polymerase subunits RpoB and RpoC (By similarity); The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA (By similarity).
Sequence:
MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHEAEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTEGLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGEILNIPVGTVKTRIHRGREALRKQLRDL
The following text describes a protein:
Function:
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle. Secreted.
Sequence:
MRNPRSWKPRALPPPGILGVRTETDWPGEQFSPLCPNCHLEVISAIAVELLQPGRPKMLGSKRLGLSGLTLALSMLVCLGALAEAYPSKPDNPGEDAPAEDLARYYSALRHYINLITRQRYGKRSSPETLISDLLMRETTENVPRTRLEDPSMW
The following text describes a protein:
Function:
Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination. The velvet complex acts as a global regulator for secondary metabolite gene expression. Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes. The velB-VosA complex binds DNA through the DNA-binding domain of vosA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes. The vosA-velB complex binds to the beta-glucan synthase fksA gene promoter in asexual spores for repression.
Subcellular Localization:
Nucleus. Cytoplasm. Note=VeA increases the nuclear localization of VelB.
Sequence:
MYAVEDRAHSGHHPPPLSMDRIPPPSTMYPSSAGPSAMVSPAGQPEPESLSTVHDGRIWSLQVVQQPIRARMCGFGDKDRRPITPPPCIRLIVKDAQTQKEVDINSLDSSFYVVMADLWNADGTHEVNLVKHSATSPSISTAMSSSYPPPPHPTSSDYPASYQTNPYGQPVGQPVGQPVGYAGVGNYYGGSTQLQYQNAYPNPQAQYYQPMYGGMAQPQMPAAQPVTPGPGGMFTRNLIGCLSASAYRLYDTEDKIGVWFVLQDLSVRTEGIFRLKFSFVNVGKSVSDLPQSDIAEVINKGTAPILASTFSEPFQVFSAKKFPGVIESTPLSKVFANQGIKIPIRKDGVKGQGSRGRHSDEDDGLDNEY
The following text describes a protein:
Function:
Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.
Sequence:
MEIIDANTAMLSNFEVLGLLNSSRVKGDQTRNQSGSLATITYEAIKYLEGTPAALQSEGCFKKFLEDVKKFGLTIKEKTMILNLRPKTDVEISLIVQSTDQERLTEEQIEELIELIQNTLPE
The following text describes a protein:
Function:
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
Subcellular Localization:
Mitochondrion.
Sequence:
MLLATFKLCAGSSYRHMRNMKGLRQQAVMAIGQELNRRALGGPTPSMWINQVRRRSSLLGSRLEETLYSDQELAYLQQGEEAMQKALGILSNQEGWKKESQQDNGDKVMSKVVPDVGKVFRLEVVVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTFITHELAAEAAGNLVGPRDFVSVRCAKRRGSTCVLAGMATDFGNMPEQKGVIRAEHGPTCMVLHPLAGSPSKTKLTWLLSIDLKGWLPRSIINQVLSQTQVDFANHLRKRLESRPASEARC