lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MELYADLVPLTAENFRALYTKKPLHYKGLCLSQHYPRIHVEGRRLRQGPWHRRRVHLRRHLPNENFLLPHDRPWLPNGSAENNISQFFTRVPWFDGNYVVFGCIISGFHNLKAIEAEVEVKIANRGEVVIVPPPSLTTN
The following text describes a protein:
Function:
Plays an essential role in the initiation and regulation of chromosomal replication. ATP-DnaA binds to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex once per cell cycle. Binds the DnaA box (a 9 base pair repeat at the origin) and separates the double-stranded (ds)DNA. Forms a right-handed helical filament on oriC DNA; dsDNA binds to the exterior of the filament while single-stranded (ss)DNA is stabiized in the filament's interior. The ATP-DnaA-oriC complex binds and stabilizes one strand of the AT-rich DNA unwinding element (DUE), permitting loading of DNA polymerase. After initiation quickly degrades to an ADP-DnaA complex that is not apt for DNA replication. Binds acidic phospholipids.
Subcellular Localization:
Cytoplasm.
Domain:
Domain I is involved in oligomerization and binding regulators, domain II is flexibile and of varying length in different bacteria, domain III forms the AAA+ region, while domain IV binds dsDNA.
Sequence:
MLTCNDCSTWEQFVNYIKTRCSKTAFENWIAPIQVLEESSEKIRLEIPNIFVQSYLLDNYKKDLCSFVPLDAEGNPALEFVVAEIKRSSPLVTPSIAKPATEVSEENKDFQLKLNGAYRFDNFIEGPSNQFVKSAALGIAARPGRSYNPLFIHGGVGLGKTHLLHAVGHYVREHHKNLRIHCITTEAFINDLVHHLRVKSIDKMKNFYRSLDLLLVDDIQFLQNRQNFEEEFCNTFETLIHLSKQIVVTSDKPPGQLKLSERIIARMEWGLVAHVGVPDLETRVAILQHKAEQKGLNIPNEIAFYIADHVYGNVRQLEGAINKLTAYCLLFNKPLTETTVRDTLKELFRAPSKQKVSVESILKSVATVFQVKIQDLKGSSRAKNVPLARQVAMYLAKTLITDSLVAIGAAFGKTHSTVLYACKTIEQKIEKDALLKNQISLCKNNIAIDSPQHFV
The following text describes a protein:
Function:
Putative transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAAAAAAGPGAGAGIPGASGGGGAREGARVAALCLLWYALSAGGNVVNKVILSAFPFPVTVSLCHILALCAGLPPLLRAWRVPPAPPVSGPGPSPHPASGPLLPPRFYPRYVLPLAFGKYFASVSAHVSIWKVPVSYAHTVKATMPIWVVLLSRIIMKEKQSTKVYLSLVPIISGVLLATVTELSFDVWGLVSALAATLCFSLQNIFSKKVLRDSRIHHLRLLNILGCHAVFFMIPTWVLVDLSTFLVSSDLAYVSQWPWTLLLLVVSGFCNFAQNVIAFSILNLISPLSYSVANATKRIMVIAVSLIMLRNPVTSTNVLGMMTAILGVFLYNKTKYDANQQARRHLLPVSTSDLSNREHLRSPMEKPHNGALFPQQGDFQYRNILLTDHFQYSRQGHPNSYALSRHDV
The following text describes a protein:
Function:
Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MIEYLLTVIPIAVATLLCGYIVALRLIPYQRQRVAVLVLGDLGHSPRMQNHVLSLVQNGFEVDFIGYKNSQLRQDISKAANLICIPSPAKIRTLNKRLFILLGLWRSISQTLRLFWILIYAIRKPEYLLIQNPPAIPTLLVARLVTILLGNKLIIDWHNFGYSLMSDQFAKNKLLFLFLTKYEQWCGSGAFLHLCVTEAMAKELQFSWQIRGKVVVLYDKPAAHFKQISPIEQHNLFSRLDMSSQTIQYKNPNSNESELIFTKSTAKGLAELKPDRPALIVSCTSWTPDEDFGILFRALSLYDFTVPLSKLIVIITGKGPLRSSFEQLATDLKLQHVSIKFAWLEPQDYPILVAAADLGISLHTSSSGLDLPMKIIDMFGCGTPVCTYYYPTICELVQNNQNGVYFQDETELFKKLVDLIGNFPAPNASISTLIQGVGEFKSTWENHWRERVLPLIQ
The following text describes a protein:
Function:
Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MGSSQSTPQQDTNKLSQCPIQHQNNNPLQSSTNFNESNNIPELPQAPSPGQRTKLSLQRTLSSIPRPSSPAFSAEEEDNTQVKALGNSSCPVHQSTPKKEKDTWVYPSPQQFYNALVRKGWETPEESIPIMVDIHNWMNEAVWNEVLRWESRYFFTPSSSSSSNNHPVQQQEEQQPEISLVKFQGRPHELSPKARFNILLSMIFPNLYNPVRPFDRHDWSICREHLLKQDPQVEKSKLCRYVIDYYNGGIDEDGNPVFHFDVRPAIDDLDSLVVRVKEWARIKNETWFKTPDQSTKTHPNIVQGDSKI
The following text describes a protein:
Function:
Activates transcription of the pcaDCHGB operon for the catabolism of the phenolic compound protocatechuate.
Sequence:
MIDARVKFRHLQTFVEVARQKSVVKAAELLHVTQPAVTKTIRELEEVLGVAVFEREGRGIKITRYGEVFLRHAGAALTALRQGLDSVSQERSGEGPPIRVGALPTVSTRIMPRAIALFLKEKTGARIKIVTGENAVLLEQLRIGDLDLVVGRLAAPDKMTGFSFEHLYSEQVVFAVRAGHPLISGRQSLFAHLSDYPVLMPTRASIIRPFVEHFLIANGIAGLPNQIETVSDSFGRAFVRSSDAIWIISAGVVATDIADGVLAALPVDTSETRGPVGLTMRTDAIPSLPLSILMQTLREVAGTAMAAEAKRTA
The following text describes a protein:
Function:
Specifier protein that contributes to constitutive and herbivore-induced simple nitrile formation (By similarity). Catalyzes allylthiocyanate and corresponding epithionitrile formation from allylglucosinolate in the presence of myrosinase. Also converts aliphatic glucosinolates, such as indol-3-ylmethylglucosinolate, 4-methylsulfinylbutylglucosinolate, 4-methylthiobutyl- and benzylisothiocyanate, to simple nitriles.
Miscellaneous:
MISCELLANEOUS: Does not contain the mannose-binding lectin domain present in other members of the family; MISCELLANEOUS: The proton donor differs depending on substrates.
Sequence:
MARTLQGEWMKVEQKGGQVPAPRSSHGIAVIGDKLYCFGGEDPPYESIDNDLYVFDFNTHTWSIAPANGDVPKTRVLGTRMVAVGTKLYVFGGRNKQLEFEDFYSYDTVKEEWKFLTKLDEKGGPEARTFHSMTSDENHVYVFGGVSKGGLNATPFRFRTIEAYNIAEGKWAQLPDPGEDFEKRGMAGFLVVQGKLWVFYGFATANDPKIPTLYGSQDYESNRVHCYDPATQKWTEVETTGFEKPSRRSCFAHAAVGKYIIIFGGEIERDPEAHQGPGTLSREGFALDTETLVWERYEGGPIKPSNRGWVASTTTTINGKKGLLVHGGKLMTNERTDEMYFFAVNSST
The following text describes a protein:
Function:
Probable transcription factor; Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MRRRVANGAGGGPPVFPMVPSDDGFGVGMEDDDADEDMAMCGGGGGGAGEKKRRLSVEQVRALEVSFEKENKLEPERKARLARDLGLQPRQVAIWFQNRRARWKTKQLERDYAALRQSFDALRADHDALRRDKDALLAEVKALKAKLEDGPAAAAASFSSVKEEPTAAAAAQGSSESDSSEVLNNAAVLAPEDKTTPTPMHTAAKAKAVVPLEMGLYAVHGQQLLLKVEDDEAAFLGDDDAACGGFFADEQLPSLPWWTEPTDPWA
The following text describes a protein:
Function:
Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene. Plays a role in nucleosome localization of the PRC2 complex.
Subcellular Localization:
Nucleus.
Sequence:
MDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRLEN
The following text describes a protein:
Function:
Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.
Sequence:
MILLNNSHKLLALYKSLARSIPESLKVYGSVYHINHGNPFNMEVLVDSWPEYQMVIIRPQKQEMTDDMDSYTNVYRMFSKEPQKSEEVLKNCEIVNWKQRLQIQGLQESLGEGIRVATFSKSVKVEHSRALLLVTEDILKLNASSKSKLGSWAETGHPDDEFESETPNFKYAQLDVSYSGLVNDNWKRGKNERSLHYIKRCIEDLPAACMLGPEGVPVSWVTMDPSCEVGMAYSMEKYRRTGNMARVMVRYMKYLRQKNIPFYISVLEENEDSRRFVGQFGFFEASCEWHQWTCYPQNLVPF
The following text describes a protein:
Function:
Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence. Acts as a transcriptional activator and repressor. Binds synergistically with POU5F1 (OCT3/4) to gene promoters. Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation. Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG. Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity. Regulates transcription of HRC via binding to its proximal enhancer region. Involved in skeletal muscle regeneration. Also plays a role in the development of myogenic precursor cells.
Subcellular Localization:
Nucleus.
Sequence:
MALTSSSQAETWSLHPRASTASLPLGPQEQEAGGSPGASGGLPLEKVKRPMNAFMVWSSVQRRQMAQQNPKMHNSEISKRLGAQWKLLGDEEKRPFVEEAKRLRARHLRDYPDYKYRPRRKSKNSSTGSVPFSQEGGGLACGGSHWGPGYTTTQGSRGFGYQPPNYSTAYLPGSYTSSHCRPEAPLPCTFPQSDPRLQGELRPSFSPYLSPDSSTPYNTSLAGAPMPVTHL
The following text describes a protein:
Function:
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKKGVLEMIRSFYIAAKDLKAEFRTKQMLNSMFIYSLLVLVVFSISFGDFLGDSSKVEKLAPGVLWIAFTFAGMLGLSRTFVMETENGCLEALMLCPVDRGAIYTGKILSNLAIVFLMEAVTLPFFIILFNYNLGKGTLLLLLLILFLGTFGFIAVGTLLSALTLGTRTRELLLPVILLPVLLPVLIPAVEATAGVLAGNSIGNLLPEIRLLAVYDLVFFVISHLVFEYVVSD
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
Sequence:
MEVKNIGIPHVLPPASVCDDPLCPWHGHLKVRLKLLEVTVEKVRMHKAAVVIHEWLHYIRKYNRYERRRKRMRVRVPECIEVKPGDKVIIAETRPLSKTIAWVVIGKKEDVVEWKAKHETLQA
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MGRKKGLPEFEESAPDGFDPENPYKDPVAMVEMREHIVREKWIQIEKAKILREKVKWCYRVEGVNHYQKCRHLVQQYLDSTRGVGWGKDHRPISLHGPKPEAVEAE
The following text describes a protein:
Function:
Ubiquitin-like protein modifier which can be covalently attached to target proteins and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Conjugation to the target protein is activated by UBA6 via adenylation of its C-terminal glycine (By similarity). Probably functions as a survival factor. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Accumulates in aggresomes under proteasome inhibition conditions.
Sequence:
MASVRTCVVRSDQWRLMTFETTENDKVKKINEHIRSQTKVSVQDQILLLDSKILKPHRKLSSYGIDKETTIHLTLKVVKPSDEELPLFLVESKNEGQRHLLRVRRSSSVAQVKEMIESVTSVIPKKQVVNCNGKKLEDGKIMADYNIKSGSLLFLTTHCTGG
The following text describes a protein:
Function:
Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
RENVVVPLTKVTKNPGEKKKKLINTIKDTIDNYKSIYLFTYENMRNNKLKALRTAWSTSKFLFGKNKVLAYGLGKSEEDELKTGLHKLSEHLEGECGLFFTNEPREKVLEYFENFSEKDFPRSGFVPEETITIKEGPLTGFVHSMETYLRGLGLPTSLKNGVIYLERDYDICEEGVAINPDQSQLLKLFNHQISEFKIVVKGVYTEEEFTLLNGQEPIEE
The following text describes a protein:
Function:
Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.
Subcellular Localization:
Nucleus.
Sequence:
MESADLIPLLERLDDDVDDLEEAIAPILQSTVVETSKKLPVLDKAKFHVMTAYALESLVFSYLRLHGVKATEHPVYRELKRVKQYFDKIKALETEPEQRTMVLDKQAAGRFIKHGLAGNEKLDLQREEQLAKEKARAQLKASLLAKKAGDTTEEPPKDVSSESEIDTDPTSDIASDAKGADLLQEVQSSEAPGASSKKTKKNKAKSSAKDERRKKRRGKEEFKDHNKQRRKKKDDTRKARKAT
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSLYVDSLIFQRLEKVKAEIKLCPTETSGTIHRQAASSKQYPVETSSRPKSEGAAQKRTLQKCFEEVLENFKMGEPQQVSALPPPPMQYIKEYTDENIRKGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHTEGGMRLKTEPMDTDDSKNCIGQNEQRENSSHRRDQIIEKDAALCILIDEMNERP
The following text describes a protein:
Function:
SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for sumo2 and sumo3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (By similarity). Is a component of complexes that can bind to U snRNA genes (By similarity).
Subcellular Localization:
Nucleus, Cajal body.
Sequence:
MNGEGTGIGAPTPALAGFLGKSKDRNASPGNCPWCLAKGQTNALRFYAVNLKETVLLCTNAVCLYPLVSRSLEEVRASLSKGGCKRSISSLPDISDDSCPPKRPREEKLDVLADVSEPCDAEVNDATLPDDTVKTQTFTDQQSAPAETISLDKTEEQPVSIEDIKEQPISHDATEGQPISIDQTEEQPVSILHTEEQPIVLDLIEVKPMSVDHSEEQPICIDNTKERPVSIVHTEEQSIVLDLFEVKPMSIAHTEEKPTSFDHIEEKPMSIAHTEEKPVSLVHTEDQHLSIDQTEEQPISIDPTEEQQPEELPAVSDEDVDLCERKEDCVSSTQDEMEEEVLESSSELVPVHSELFWKNEENMCWLDAMLVMLVHCRTIRGTPCRGIKLSDKLATVPCNDSVVWKLCWRYDKTCAYLQARKKQSEDKVLRVPAGVLVEAERRLSALRLSVFKLLQPTLKCEIGQQETPVFALPLLLRSDKWAQDIFQHTIRWEFKCTCCDFTVNESVEKTLTTLTCIVKDWHPLKANNRTQCNKCEHKNQRRKMVLEKLSSVFALHFVEGLPRKDLTKYGFTFQGFQYSVSTIIQYNKHLQHFVTWVRQSNGFWLELDDLKHPYSPTHKRLPFPSSEFHILFWETDSFKEEHSEVCLPTAPPEVPNAPDEHPPKLSDSVATDTCVISALTVEDTTASSIADTSIGSTTLLDTFEGLTHKDIVTLTLVNSESPKNEPRPMRPGFVSAPRHCPFEASNLLSGIPKTGSRLSTPPIPQKSSLVHKPEVAAAAVSKTHLQPTSLFQRHPSFQSTPIRPPPPLPPAPKPKPSLQYDKHEDLPVKPADMFGGFKTKKLANSQPKQISLPGGLNPSVKKTAGQEPISTTEALRLKLMKKLKAKKKKLAKLNQLLGNGGESVAKPDSTALSSPYSVTSSTTTYDSFDDQFLADLLSPATTVSNLSPDSTGLLEMLNNGQNGEQQNPAVATLAPEATLTCSSSTISPLDEYMQSGMCHTALENADFNSLDIFF
The following text describes a protein:
Function:
Sphingomyelin synthases (SM synthase or SMS) synthesize the sphingolipid sphingomyelin (SM) through transfer of the phosphatidyl head group of 1,2-diacyl-sn-glycero-3-phosphocholine (phosphatidylcholine, PC) on to the primary hydroxyl of ceramide (N-acylsphingoid base), yielding 1,2-diacyl-sn-glycerol (diacylglycerol, DAG) as a side product. Functions as a bidirectional lipid cholinephosphotransferases capable of converting PC and ceramide to SM and DAG and vice versa depending on the respective levels of ceramide and DAG as phosphocholine acceptors, respectively.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MSVTVEVADEETHDVPLVEQVRTTPDQNVDVKVQENNVVTTKIGPKLETIPAAKMQDDNGDEEKAENSEGAAAEKVEKQHDDDGVVVHEETDGVASSRSSHHDKQKPGETKKSGDGKMDDDDIITTARSSSRRICGSAASSSDSETADDAPLLPDEGPSHAVRLEMPGDKPASPHDRFPKTPLKTLVAFLMLVVAAAGNTITLSWIHERYPLTPPLPDIVFELIPKIPWGLRLCENLMIGSFVSLLVLILFHRHRWIVLRRLCFIGSILYGMRCITMMVTPVPKADEDFECSPRFGENATFSLIVMRGVWSMFGLGLNLFDNQKVVLCGDYIYSGHTLVLVVSALFIGEYSPRRFYILHWLSWLVCSVGVIFLVLSHGHYTIDVILSYFACTRVFWAYHTQAAHPSIRLSVQNHQAKEFWFPLLRWFEGDIRRPVPRRFDCPISYSQVCNAFRRVRPRGRNGAARPAFE
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MAPPLEIAAAPDDASTGDTFQLLKQTLELDISFCPRQVTGKTTLDILPERGQLREVILNARQLKPTQIKIEGQTASFNYSNLHQRMTLYPGTDLGQYHFPKDRIQRHVNEGADELVVYLPDSVKIREVKPEEAGQPLDAQGTFYAPLKVEIDYILDDFRDGLHFAGVEDGDSRFPHAYTRNSPFPGTASCLFPCIDDGETRCPFDVAIRYPRTMGDALSKHSPGSGTGQALVNGVDKADSVMSDSDDDAGFSEEEKAMEMQVICSGVLTDDILDPADSSRKTASFTCESLVLPQHVGFVIGPFEHVDLSDYRDLADEERLAESAIKVHAFCLPGREDEVRNSAMMLARALDSFTERFQSYAFGNAYKLAFVDDLDCDASHTASFSICSSRLLFPETIWEPLEHTTRVLVHAVASQWIGVDVIARDIYDYWIIVGASWFMAELYLRELFGRNDWRFRQKLMVDKVIQMDKKRPSLQRLGQYLQLDHAEQEFMELKSLMVLSILHNRLVKQSGKNGVDRCLYRLLFNARQGKYDNGAITTEDFLDICEKVGHQKLDSFFSQWVVGSGCPNFECFPSFNKKKQVVQLQIRQIQADSTVTTIENALSADDFMREAKESAHGFLHGNEFPTFVGPMTIRIHEADGTPYEHIVDINSSNVKVEIPYNTKYKRLKRNRLNKERQAAAAGLDASGEAQEDVTFYMLGDVFGTAKEQEEWRLSDWPAEDEAKMEGEAYEWIRIDADFEWICRAHINDMPSYMYVSQLQQDKDVVAQYESIQFLASKEGHRLISTFLVKTLMDNRYFHGIRTYAADVMAQSALKRTEWTGLYHLKKAFRELFCIPGSPMTRSNDFSDRSLYLIQCAIPKAISKIKGEDGRAPLEAKRFLLDIIRYNDNRGNEYSDDYYISTLMHCLADCLTANKSGDMELFDAETERDEFEFTKKAIEELTRHQRLDEWIPTYQNVYTTTALDCARKLIMNRVTPFKPSEFLQYAQLGNADNVRLKAWDCLVRLGMLRKDAVLKFLMHDIRSDPSPYFRKQLLRVFSFAIGQIATGDVYTPEKPADNTLGGLVVETDADNSDRASQLARQNLNGAQRGLKTDLQNNQTLKDALEEALNSKTLSTSDMLELLDFCNMVFDHLKRNTLPIVLRMPRYWRMENLGQGRLRFTQTGAYRKRSKPAHVPVVEDVVAPVPLVPMAPVVQAPPPVSAPKLKMSLKLKPAGSPPPPSADPGPPKSRQQSGMFSPPVVNSPTSLPESAKASRAPTPAAAKPESRAPTPKPSPAPVVAPPSKPATPAPVVKTPVPPPAPPAPVVAAPSRPAPAPVSIPTGISTPPAIHSPIPLPTTTTKLKIKTKLGPASASARASAAPSPRPSAAPSPRPSAAPSPRPSAAAVPTIKAPTPASSSATPKGPKQKRKIVKLFLRPELLARFTNDRKRKLQVDDSDRPLKRQSLEPKSGRKTGLVQWDKYGGDKPRLIVKMKVGKGKLPIE
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MQTFQKPENALKRAEELQFIGQNEDALQILHSAIGHRTFRLQGWHILQEQIMLRYIEFCLYLEKLSLVKDGLHQYRIICQHGNIASLGKVITDFRDKAEEKVRLAKENVVLNKEKIEQEESNVDVTEKILMASLDIEITGKHERKLQNAYRICMETYKMILEILRATPKLEKAYHETAKKAILFCKENKRVTEFKKLSDLLRNHYNLILRGKHKPEYQSLLKIEYHLETKIIQLEAACELAMWKEASNIAEDIYNLNMHDYFYKSLKSNIMMEPELVSVIDTVKSGDKNEEEKNKVNDVDADAKAKEDILKGVEQQDNNVENNNNNNNNNNDNNNNNNNNNNNNNNNNKEDEEDGKIQSGDTITKTTDGNVGTGHNTSHSLNQSKEKLRNWIAIFYEKMADILFVYESELFHGLAWLKYCFHILNFKRNMTEKEKTYICNKAVLAVLSIPVIGNKKKSEDFTKQFEAHKKMSQLLGHTSVPVKESLKNALRIRNILNYADENIQKLYSLLENQFTPLSLCLECEVLLKELENTEYAIYTKKIKEVIFHKLILQLSRVYSYISIDYFIENICPDHFMSWNEAEKMLVDLVYQRELEMKIDLTMRAIHFGDKQVLNSSVMIKDSLINMYNDLQNGLKMINETIAIENEVENLTMSTLTYEEEFAYLDKSNKNINYNTATLEDIIENEVFEEKPIENEKLLKKIYEKIDEEHHKIQLLSEEHNKKRKELLKKQKELEQAQLKLKMEKKLLEEKLEKEKKEELARKGEKLRIKEEKHKKKTEAAEQMLKEIKKLCSTNTTKILMKGKYMDEITIDDILNGYVDFDDIEEAQEKLRLNERNEIIKVRKMEAKKVDHYFRAVRQVELSHMNRWIALVFQEDTEILLQEQKAAEEEQKADFEAALKEKEEYVKFSIDIEEFTKNEMKLRVEEFEKNLKAQKERLYNILKEEKIQRAKERRDQHIRKLKAEEERKRREEEEERLLKEEMERKKKEEARKKLEEISKAQRERDLEMDLQMKRKKEESRRSERSHRKSSIDDDLTWRRGDKGGSQNGDDSYRRHDDHHDGTHRDRSEMRDRRDWSGRDRDRDRERDRDRDRDREHRRDRDRDRERDRDRDRERDRDRDRERDRDRDREHRRDRDRDRERDRDRDRERDRDRDRERDRDRDREHRRDRDRDRERDRDRDRERDRDRDRERDRDRDRERDRDRDRERERDRDRDRDRDIKRSDRDHKKDRDDKLDRDSRRRERSGKPENEKKRENDISKRNGTTEERTKNAWNLKEDDDSKAKHETSEENTKSWRNNNKVIDNEIEKAEKYKDGEKKDGEKNKDENSSKNKENDELANGNEENENDEVKKNDDEEASDGGDFTVFKKKKRNILRFFMKA
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKNGSQLKNLKSSIRQANLGTRPNNKKSRTRSTESHEDRQAKVQKIQSDFNLFDRQFTKRKFDVGGRRVKGTEGKPGVSRGVGEELRRRTIGAELKKRNRSGAIIDRRFGENNPHLSVEEKMLERFSREQQRRSKRELYNLDAEDVLTHGNRPLSDIDSFEEPGFGLDEGEELNDEVVRRMHFGGFEDSDAENEKEGEGAHKSKREVMSEIIAKSKHYKAERQAEKERYEDEREKLDEQMEDLQSFLSDYKKASRKSGIKTQRPIISDGDARYDSFVREMVFDKRAHPTERTKTEEELAQIEADRLRELEDQRISRMEHYQEDSASEAGSIEDEQATDNVFGFGKGLEQENEEEWNGINEEAEESEDEESVNSDTSFVDDEQLKVEEQPLVGSAIKNEGSEKASLAYTYPCPTSHVEFVQLLKGLDYKDYPTVVSRIRTLHHVKLHPDNKSRLENFSVILLQHILHLTRQPMISMELLEHLTEHLHSLAQQFPSALGISFISVVEGMRKRLAKSYVYPEIKFPEISDLLFFNLTGSIFPTSDKKHIVVSPVMLTMAESLSQSPADSLSDVCKKLYIANLFLKFQSYSHRYVPEVITAVSQALYLLYPNFISIVPGTFALPDSLKEKQNLFAIQDISLDEPQRLSLYELEELPTGLLQSSILFITLNLIEMAIDIYFKEQAFIEIFVPIMDMLQLYSLKKELLSKRLSEKLLSTLQAVSDSIESAKANRKPLALQSHRPLGITSQVPKFEEGYSLDKSSHDIDPERAQLNKLRAQHRDAKKGAIRTLRKDARFIARERRQEQRAKDQAYNEKMRKLENRLQHFDPAV
The following text describes a protein:
Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Subcellular Localization:
Secreted. Cell membrane.
Sequence:
SIRNPQLYPLKPCKGTASMTLGCLVKDYFPNPVTVTWYSDSLNMSTVNFPALGSELKVTTSQVTSWGKSAKNFTCHVTHPPSFNESRTILVRPVNITEPTLELLHSSCDPNAFHSTIQLYCFIYGHILNDVSVSWLMDDREITDTLAQTVLIKEEGKLASTCSKLNITEQQWMSESTFTCKVTSQGVDYLAHTRRCPDHEPRGVITYLIPPSPLDLYQNGAPKLTCLVVDLESEKNVNVTWNQEKKTSVSASQWYTKHHNNATTSITSILPVVAKDWIEGYGYQCIVDHPDFPKPIVRSITKTPGQRSAPEVYVFPPPEEESEDKRTLTCLIQNFFPEDISVQWLGDGKLISNSQHSTTTPLKSNGSNQGFFIFSRLEVAKTLWTQRKQFTCQVIHEALQKPRKLEKTISTSLGNTSLRPS