lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to esters. Involved in the behavioral responses to butanol, pentanol, hexanol, octanol, propyl acetate, and butyl acetate.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVRYVPRFADGQKVKLAWPLAVFRLNHIFWPLDPSTGKWGRYLDKVLAVAMSLVFMQHNDAELRYLRFEASNRNLDAFLTGMPTYLILVEAQFRSLHILLHFEKLQKFLEIFYANIYIDPRKEPEMFRKVDGKMIINRLVSAMYGAVISLYLIAPVFSIINQSKDFLYSMIFPFDSDPLYIFVPLLLTNVWVGIVIDTMMFGETNLLCELIVHLNGSYMLLKRDLQLAIEKILVARDRPHMAKQLKVLITKTLRKNVALNQFGQQLEAQYTVRVFIMFAFAAGLLCALSFKAYTNPMANYIYAIWFGAKTVELLSLGQIGSDLAFTTDSLSTMYYLTHWEQILQYSTNPSENLRLLKLINLAIEMNSKPFYVTGLKYFRVSLQAGLKILQASFSYFTFLTSMQRRQMSN
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSARLLRSAVVRATQQRTMYENPYINRFKARSKVSEDFHKKTTGITGLFVNEHPHRALTVVYGRILRALEQMPRDAAYRKYTEAVVKQRLALVQAENDIKKLEEKIGMGQIEEVIEQAEYELETTRAMIDSKAWEPLVETAPKGQWSWPV
The following text describes a protein:
Function:
Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein. Note=Displays a somatodendritic localization and is excluded from axons in neurons.
Sequence:
MRMCDRGIQMLITTVGAFAAFSLMTIAVGTDYWLYSRGVCRTKSTSDNETSRKNEEVMTHSGLWRTCCLEGAFRGVCKKIDHFPEDADYEQDTAEYLLRAVRASSVFPILSVTLLFFGGLCVAASEFHRSRHSVILSAGIFFVSAGLSNIIGIIVYISANAGDPGQRDSKKSYSYGWSFYFGAFSFIIAEIVGVVAVHIYIEKHQQLRARSHSELLKKSTFARLPPYRYRFRRRSSSRSTEPRSRDLSPISKGFHTIPSTDISMFTLSRDPSKLTMGTLLNSDRDHAFLQFHNSTPKEFKESLHNNPANRRTTPV
The following text describes a protein:
Function:
Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression.
Sequence:
MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELNVTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLASQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKILFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLVSTEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNRELAPSANDFYEFVIQFFSKLEQYQ
The following text describes a protein:
Function:
May play a role in embryogenesis.
Sequence:
MPKCPIPIRISFFSYFLKESRILSSNPVNFSIHLRFSSSVSVSPNPSMEVVENPLEAPISEKMFKSAPKMGSFKLGDSTLSSMIESYANSGDFDSVEKLLSRIRLENRVIIERSFIVVFRAYGKAHLPDKAVDLFHRMVDEFRCKRSVKSFNSVLNVIINEGLYHRGLEFYDYVVNSNMNMNISPNGLSFNLVIKALCKLRFVDRAIEVFRGMPERKCLPDGYTYCTLMDGLCKEERIDEAVLLLDEMQSEGCSPSPVIYNVLIDGLCKKGDLTRVTKLVDNMFLKGCVPNEVTYNTLIHGLCLKGKLDKAVSLLERMVSSKCIPNDVTYGTLINGLVKQRRATDAVRLLSSMEERGYHLNQHIYSVLISGLFKEGKAEEAMSLWRKMAEKGCKPNIVVYSVLVDGLCREGKPNEAKEILNRMIASGCLPNAYTYSSLMKGFFKTGLCEEAVQVWKEMDKTGCSRNKFCYSVLIDGLCGVGRVKEAMMVWSKMLTIGIKPDTVAYSSIIKGLCGIGSMDAALKLYHEMLCQEEPKSQPDVVTYNILLDGLCMQKDISRAVDLLNSMLDRGCDPDVITCNTFLNTLSEKSNSCDKGRSFLEELVVRLLKRQRVSGACTIVEVMLGKYLAPKTSTWAMIVREICKPKKINAAIDKCWRNLCT
The following text describes a protein:
Function:
Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.
Subcellular Localization:
Secreted.
Sequence:
MAGSLSFILLCLQVVSVVLANSDPSAHIHRRSPEKAPKPSGSRAPKAPAPGVVPSPIRGPNGNSPDPKGTAKPVPFGFGSKVTGGGNATPQTPKDTAQLEAWLTDKVPRVILINKTYDFTSPTNTTANGCQPWKACSNGLKVQKAVNFDHWCSKEKTFASNIAVTIEASPLSPIKIGSRKTLLGVGRSAIIKGKGFLLYRVDNVIIQNIHITWLNPHIVWGGDGIMMDGAKNIWIDHCSFSYIGRQMIVTGGTTQAEANTGITISNNLFSGRTKWSARCQDRHYWTALFSGANDQITMARNCIDSTSGRSPKTGGSGNPKVLLHYYNNLHTNIIGETLEVGSGSNLLAEGNVFENVKIQDPGDLKTQDGGHSYVPLKPAEADRCKSILGRPCATNLLIQSSPYKFSVDTQAVDAFKVYPAAAQAKVLPASSIQHGVPGRCGVGYM
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MLKGEVIGDFGLDCLMIAFLMNRAADLSASTFNPPSLMTAVSKEGLLELEAEKQRACVHCRATRTPLWRAGPAGPRSLCNACGIRYRKMKMNSNNNGGVNNNSNNKMGKGKKMGGSGGSLKVRVVRLGREIMVHRPTTAMEDDNEVAESIGEEEQTAALLLMALSSGYV
The following text describes a protein:
Function:
Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Domain:
The SCAN domain enables PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion.
Sequence:
MLPPKHLSATKPKKSWAPNLYELDSDLTKEPDVIIGEGPTDSEFFHQRFRNLIYVEFVGPRKTLIKLRNLCLDWLQPETRTKEEIIELLVLEQYLTIIPEKLKPWVRAKKPENCEKLVTLLENYKEMYQPEDDNNSDVTSDDDMTRNRRESSPPHSVHSFSGDRDWDRRGRSRDMEPRDRWSHTRNPRSRMPQRDLSLPVVAKTSFEMDRDDDRDSRAYESRSQDAESYQNVVDLAEDRKPHNTIQDNMENYRKLLSLGVQLAEDDGHSHMTQGHSSRSKRSAYPSTSRGLKTMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDRSQRFPRMSDDNWKDISLNKRESVIQQRVYEGNAFRGGFRFNSTLVSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEMRKAMSMSSLSSLSSPSFTESQPIDFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEYGESFIHSVAVSEVQKSQVGGKRFECKDCGETFNKSAALAEHRKIHARGYLVECKNQECEEAFMPSPTFSELQKIYGKDKFYECRVCKETFLHSSALIEHQKIHFGDDKDNEREHERERERGETFRPSPALNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPGQSLKRRQKTYNKEKLYDFTDGRDAFMQSSELSEHQKIHSRKNLFEGRGYEKSVIHSGPFTESQKSHTITRPLESDEDEKAFTISSNPYENQKIPTKENVYEAKSYERSVIHSLASVEAQKSHSVAGPSKPKVMAESTIQSFDAINHQRVRAGGNTSEGREYNRSVIHSLVASKPPRSHNGNELVESNEKGESSIYISDLNDKRQKIPARENPCEGGSKNRNYEDSVIQSVSRAKPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHRSNETSVIHSLPFGEQTFRPRGMLYECQECGECFAHSSDLTEHQKIHDREKPSGSRNYEWSVIRSLAPTDPQTSYAQEQYAKEQARNKCKEFRQFFATSEDLNTNQKIYDQEKSHGEESQGENTDGEETHSEETHGQETIEDPVIQSSDMEDPQKDDPDDKIYECEDCGLGFVDLTDLTDHQKVHSRKCLVDSREYTHSVIHTHSISEYQRDYTGEQLYECPKCGESFIHSSFLFEHQRIHEQDQLYSMKGCDDGFIALLPMKPRRNRAAERNPALAGSAIRCLLCGQGFIHSSALNEHMRLHREDDLLEQSQMVEEAIIPGLALTEFQRSQTEERLFECAVCGESFVNPAELADHVTVHKNEPYEYGSSYTHTSFLTEPLKGAIPFYECKDCGKSFIHSTVLTKHKELHLEEEEEEDEAAAAAAAAAQEVEANVHVPQVVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAEGPDGEAAEPIGEAGQPNGEAEQPNGDADEPDGAGIEDPEERAEEPEGKAEEPEGDADEPDGVGIEDPEEGEDQEIQVEEPYYDCHECTETFTSSTAFGEHLKTHASMIIFEPADAFGECSGYIERASTSTGGANQADEKYFKCDVCGQLFNDRLSLARHQNTHTG
The following text describes a protein:
Function:
DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair. Not required for the repair of DSBs induced by ionizing radiation or UV light. Has an important role in morphogenesis, positively affecting the capacity to form hyphae.
Subcellular Localization:
Nucleus.
Sequence:
MTYFLNDIRPPSPNDITPSFTLLTKELFDKLDGVRKESLGDFRTVTEKKAFIIKTFINTFRTHIGNDIYPSAKLIFPEKSGRIYFIKEVALARLLIKMYKIPKESEDYITLHDWNKSYQRSRRFSIDEKKIRDLPLQASRIISKRRPIVDKLEEYTVPQINSSLDQLALEKVSQGQIDILKPLFDNLSIPEVRWLIHILLNKSILTSMERFFFNTWHPDGYRVFSICNDLQKTLQFSTNPDLRLDPSQLAIHPCFKFKPQLSERLTTSYKTLVKKLQRKHEMDPPYEKKFQELGLENKFYIEEKMDGDRMLLHKDGDSFKFFSRRLKDYSYLYGESFQFGALTKFLAHAFAGNIQSVILDGEMVAYDYERNVILPFGTLKSSAIQESVRQFTTIDQYEQQTAYPFFLVFDILFLNGKDLTNYPLFFRKNILNRILRPIPNRFEVLDTRLGSSSEDIERAIREVVSSRCEGLVLKNVQSKYEIDGFRNPDWIKVKPEYLEKFGENLDLVVIGKSPAIKNSYMCGLKSVTDGVYYSFCTCANGIEIEEFDKIERLTHGKWIKTDVSMPPESLIKFGTKIPTFWIHPSDSLVLEIRARSIDTRAGTSYAVGSTLHNNHCRKIREDKSIDECVTLQEYTHIKANYINDLNKAQTALGKKREPVYSLDNESKLKKVKVESDLFSGIEFLIMSDKREADGEVTTIEEMKAMVKQYGGKIVNSVDLATNYQIMVITERELPVSSQYLSKGIDLVKPIWIYECIKRGCVLQLEPYFIFASKNWDNFNHMVDQYGDSYIIHHPLNIVVPKLSESELEDLRNGFDWGDLKPWIYLFKGLSFYVCGNNLSARFLKERIERFSGDLSKHFIECCYIVIPDNHSRPLMLREIDKMSNQISREMVIDKNGGSSRIPHFVTEAFVQASIKMNYIPDPDDYKFR
The following text describes a protein:
Function:
Involved in transport of capsular polysaccharides to the cell surface. May function as a membrane anchor for capsular polysaccharides. Possible porin properties.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MFKVKFYIRHAVLLLCGSLIVGCSAIPSSGPSAKKIVSLGQQSEVQIPEVELIDVNHTVAQLLYKAQINQSFTQFGDGYASAGTLNIGDVLDIMIWEAPPAVLFGGGLSSMGSGSAHQTKLPEQLVTARGTVSVPFVGDISVVGKTPGQVQEIIKGRLKKMANQPQVMVRLVQNNAANVSVIRAGNSVRMPLTAAGERVLDAVAAVGGSTANVQDTNVQLTRGNVVRTVALEDLVANPRQNILLRRGDVVTMITNPYTFTSMGAVGRTQEIGFSARGLSLSEAIGRMGGLQDRRSDARGVFVFRYTPLVELPAERQDKWIAQGYGSEAEIPTVYRVNMADAHSLFSMQRFPVKNKDVLYVSNAPLAEVQKFLSFVFSPVTSGANSINNLTN
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MEEDFSNSVVLVITEGDHDSRKRSLSREIDGQEMGCEEWQSLVADSFTLNEIRIRVDKELLSQHSTYFKGYLNFSERNCESLNVNWSLPIFCDLLRCIHGFEPCLSSSMIASLIEGAIYFGVEDVITKCKAWVASDTFCVKWKIEDDLVSELLSIWLSATVNGVKSIEQLCIKSLAVNFAQAMRQESFVTLPLSLLEASIDHPQLTIKSEMDLCKALLLWYESQKRNSRNGAVVDDPILLFKKIQLNLLPIDFILRELVGKYPLNIFHVSVAATESDVDVLNSIIDFKGELAAKPVKDYLNFKPVIRLTDHLKELDLSGCHQITCHHLISAAAQNGMKPKRIAQKTLVTIEQETWPELAEFINLETLILSHCWRVEQRNLVTWLNLVCPNLRELRAPHCPQLLQVILEIGSGLPNLSVLDLSVSEELVEIEGVVTRTKSTISQRLPLRWSFGKLHETNKLTDLSLRGHSEITDEILLFIARSCPLLRVVDLGGCLELSDVGFAAFLNFQENLAFQKLSAAGTRFGPVSCKALISQANISVNVLDTLNLNKCLALGCGHLSNLLQVLPSLVSLELAFTRLDDMALSAFSGTSLRHLNIRETKVSGGVLYRILARNFDLKDLNIRGCTQLALNSFDHLPSEKTFERMWENVGIGWGLSDSTISSFGFASCTLQNFAVGVGGTISEETLLCIAEQCHELKRLSLCFQFVADEGLIQAVSQLKSLHTLELQNMACAPRNLLTEIASSLPNLRNLKLERVTPLLSDDDLLLFSQSCTGLQSLSLLGCHLLTSISLSTMAHSWRGLQDLRLEECKYIITEENVRLLLNSFPALKLLHLRHIGKVLPEYFILEAIRRLPLLQKLAIDLCDAANEKFSFSEGVERSALKSVYINRCKSVRDAFYGVRDLTSEGISPYDSRTHKDTIVLEWNSVRLTESVVNERLTFE
The following text describes a protein:
Function:
Involved in the hydrolysis of the beta-gamma-phosphoanhydride linkage of triphosphate-containing substrates (inorganic or nucleoside-linked). Catalyzes vigorously the hydrolysis of inorganic triphosphate (PPPi), however it can also catalyze the hydrolysis of ATP to ADP and phosphate. It can use ribonucleotides such as GTP, CTP, or UTP and deoxynucleotides such as dATP, dGTP, dCTP, and dTTP.
Sequence:
MGKEIEKKFIVSGDAYKSLAKGVLYRQGYIFFDKDKSVRVRVFNDKGYLTVKGTSTGISRLEYEYEIPVGEANEILEYLCEKPVIEKLRYKFQFEGFTWEVDEFLGENEGLVIAEIELPDENAVFKKPDWIGREVTGDPRYLNSNLVKNPYKNFKE
The following text describes a protein:
Function:
The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein. It acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization. The carboxylated form binds strongly to apatite and calcium (By similarity); The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development.
Subcellular Localization:
Secreted.
Sequence:
MRTPMLLALLALATLCLAGRADAKPGDAESGKGAAFVSKQEGSEVVKRLRRYLDHWLGAPAPYPDPLEPKREVCELNPDCDELADHIGFQEAYRRFYGPV
The following text describes a protein:
Function:
Involved in glucose repression of glucose metabolism genes.
Subcellular Localization:
Nucleus.
Sequence:
MEFTATNSDREMHPPPVAVPSHLQQSTTHRTVPKTNPKTGKSEMPRPYKCPICDKAFHRLEHQTRHIRTHTGEKPHECTFPGCTKRFSRSDELTRHSRIHLNPNTRRAKNMNSAAAAAHNAAAQQKGPPSNQQPKDDRTDRLVAISNLVDHHDAHPPIPGGSGIKSEYSSAYSTPYSSVPSSPTMGQASLYRPYGAGPGGPPPPGGPGGLGGPAPPGPPGHHGGPPTHIGLPPLHHPPPPGGPHSAAPSAPNSTPGSPMFVRVPHSTYPRSTFDMNMLATAASQQLERENAPPSGLSSGAPSAAPSGTSSPFNHSPSSSPLQSTQSSPALASYFSRPPAPSSNPGTPGSSHGPPYGFSSGTSLSSHGNTHSNHFQHPQHLHPPHHHHGLQGHIFAGLQRMTPMSGRDDSEPWHRSKKSRPNSPSSTAPSSPTFSNSESPTPDHTPLATPAHSPRIHPRDLEGVQLPSIRSLSIGRHVPPTLPPMEIAPRSSGGTHTGTHTPYGGGSASHTPFGTSPNSGVPPPHPNAAQGAASSLSMLAMAGLNHAAGGAAPGGSGAAATSSTRDEPSNDTSGPASGSGPSAPSTASSSTRMAVSDLIDR
The following text describes a protein:
Function:
Promotes cell adhesion to laminin and fibronectin.
Subcellular Localization:
Secreted.
Sequence:
MAKNGLVIYILVITLLLDQTSCHASKFKARKHSKRRVKEKDGDLKTQVEKLWREVNALKEMQALQTVCLRGTKFHKKCYLAAEGLKHFHEANEDCISKGGTLVVPRSADEINALRDYGKRSLPGVNDFWLGINDMVAEGKFVDINGLAISFLNWDQAQPNGGKRENCALFSQSAQGKWSDEACHSSKRYICEFTIPQ
The following text describes a protein:
Function:
Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits. Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. May function as a ribosomal silencing factor.
Subcellular Localization:
Mitochondrion.
Sequence:
MNFTIFSRFLNPITKHRPINLNGYHRYYATYWLNHNRPCKNPESTLSCYRHQHHHTWIQKDVLSNMKGALANFGGSFSFLTNSTSNYLSVAQVTDLLRQERGKDVCAINISPEYCYVDHIVICSGSSTRHLRGMATSLKSQFRGKHLPGIGKVLIEGEDCQDWMAIDIGNMVVHFFLPETREKYQLEKLWLLGPQYDDLTISMSLTEDLMNKHWNK
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MYYGHEPHDWGTSSSTSDMKECTICEAPSNGYHFNAASCSACAAFFRRTVTLNRNFVCTHQNTCRVNYAMRVICRACRYHKCINMGMERSAVQPRRDCNAGRRKIMYNSTNSLKTQEHTFAPPTPTVPQTTTVIVTKDERIYEDSSPEIHYAQSYSSSISEEISSLSPKISVSMCSGTDITLNFEAEQVLEDLLREERLFNERRKLLYCSNSCISELLTNENANEIPYSQSNLQPLTFAGIQKHIRPQILVIYEWLRGWRHFELLNIKDKSVFLRRCVLYHTILDPSYLSYRLGLPEKFVMFNGMYVGVQDGDKTGWEDEKDCITADLKIKLYRPLMDRLINEVCVSMKVINLTFVEFVLLKALVCFKSSTTCEVSVPLKKFMNTYMDTILRALNVHYQTLGMTKEDIAQRIGNVILMMSSIFAVGMECLESHQKIQFFDLWQLDDLLIKLIQRGGGGANY
The following text describes a protein:
Function:
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Chromosome. Nucleus, nucleolus.
Sequence:
MNLLEEEEEFSQNSSEDNFTDEELAQQPPKKRKTKSDTDGKLKKIKYEDITSKPEKPKNELYKPPTVEELNELKETQNLYNNNLFRLQIEELIKEVKIKNKHRNAFKDWYQSFESFLNELPEYNVQLSEIKLKKKKKLSEIDNFISGIANEALKSDQDFTLKFTKPEKSEIFGLDAINALPGPKLRVNINLTMPRECFNVKDYLNNRYLVKRYYFLAYIFYHLKEKKLSGDIDWTWQHTKLLPVLRIKLHEKITIKIFATPTDNYFKLSRFLPDINNVKVDVFNVGAITEAPTIYYNASLAHDATLTLNNSFIRETLTELTNAQEAVKLIYVWLVQRGLNEGLGAFTDELILYFIVYLFTKKKINKYMSSYQIVRNFWNFISDSDLSKTPLSLSDDTKPEVLDSFKENYDVVLLDRSGCYNVASFLNLQVYKKIKSECEIAFKLLDGGINSFHSLFITKLTLELQYDLILNVKVAKIGEKMTDDERTKFLGHPELFVIKYIQGVLEKGLNKRATLIVPIVTTQSQVDKITFGINLDQSNAFHILEKGPALNDPQEREFKEFWGDLATDRRFKDGSVCVAVYFETQTIKQRREIIKTIVDWVICKKLGLEYSLHYDEFEELLVNKKVTAPYPTATNEDGCVRAIAASDELGKKLRSLEMPLAITGVQGITDVFSFTDVFPPISTNYRSGSLVTPPLENNIVLNEKKRGIVPRYVKPIECVLQLEHSSKWPKNLTAIRHMKTAFYLEIAKQLDKKHKIVASVKPEFLDVLYEGYVFRYRLYLPREVGLLKRESTNNGVTTYKDTPMSRDIELQLGILPRVTGALKGIQSQFPSFGPSTALIKRWLRSQLIDDYHFPDHVINLLNASLFLKGASVTPQVGFLRFLKFVSELQCDIQAVVVNFNNEIASETLAEIDSKLLQNREALPDLFIAMPYDGCESVFTKRGPSKLVLRRVKQLASESLNCFGQIIKGESFGSIKSLFIPNLEGYDVIIHLRPLLNPVRHEQVTGDESEGQIVLEEFNRNESTKIPVTGFNPVQLYLAELRKHYGDFANFFHDTYGGNFIGVLWIPKALESRDFKVSYASGRKLVNGKLELNVDALIEDFYIVGKGLVKSIDKKK
The following text describes a protein:
Function:
Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the ddx39b/uap56-nfx1 pathway to ensure efficient mRNA export and delivering to the nuclear pore (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm. Nucleus speckle.
Sequence:
MVPQTANMNEVIDKIDMSLDDIIKLNKEQQNKATFNGGARTNSFQWFQNKWGSRQATDNGIQGRKNGMFGVKTGLALRKMNSWKGVSPLNRPPLSLRNSEGQWSPFRRRTNLSRRLGFVPSLKRNYFHSSYAQASTFRRGLRTNQQRDQRQATYFQKRGLKVQATMDMEQLEEFPELKRAHPWRTSMNSGGILTVSIDNPTAALLPSTRLPRPTLPFLLKKEGSEPKIPKGVPLDFDINSVVKQTGITLNERFKILKEQRLSQSMSKGSRFVTVG
The following text describes a protein:
Function:
Synthesizes short RNA primers for the lagging strand DNA replication. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Recognizes two trinucleotide sequences 5'-GTT-3' and 5'-GCT-3' in vitro, but uses only the first as the priming site in vivo.
Sequence:
MSSIPWIDNEFAYRALAHLPKFTQVNNSSTFKLRFRCPVCGDSKTDQNKARGWYYGDNNEGNIHCYNCNYHAPIGIYLKEFEPDLYREYIFEIRKEKGKSRPIEKPKELPKQPEKKIIKSLPSCVRLDKLAEDHPIIKYVKARCIPKDKWKYLWFTTEWPKLVNSIAPGTYKKEISEPRLVIPIYNANGKAESFQGRALKKDAPQKYITIEAYPEATKIYGVERVKDGDVYVLEGPIDSLFIENGIAITGGQLDLEVVPFKDRRVWVLDNEPRHPDTIKRMTKLVDAGERVMFWDKSPWKSKDVNDMIRKEGATPEQIMEYMKNNIAQGLMAKMRLSKYAKI
The following text describes a protein:
Function:
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
Miscellaneous:
MISCELLANEOUS: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.
Subcellular Localization:
Cytoplasm.
Sequence:
MPEELSKKQTTRLNKLQKRLRREVGSAIADYNMIEDGDRVMCCLSGGKDSYAMLDILLNLQQRAPVQFEIIAVNLDQKQPGFPEDVLPAYLDSLNVPYHILEKDTYSIVKEKIPEGKTTCSLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETLFLNMFFGGKMKAMPPKLLSDDGANVVIRPLAYCREKDLEEYAELKKFPIIPCNLCGSQENLKRQAVKDMLNQWNRQFPGRIETIFTAMQNTAPSQGVDREQFDFVSLKRDPDAPMKGDVAEANLPAFDFLDIANSGHIDLDAAKRIDIVNVYEV
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Sequence:
MARYLTPAKIGLLALIELYVEETVPNDAIIPVLSFLTSHILDSDLQSTMTTTPGAANRWQRAERSIGLVVSIKDFEDLLLPFPAVDRLPGRRLWDRFLEKLWGIDSLDALQTFFSRQPRVLTRTREELRQMTELGEELPSGILLARNSPLGAFVRKAVLEFTRLQFHHSAELWKAFVKYRQPTVSYWRRRNPQCGRLSFDSVLMESQHEWGSFTDGIAVTAYGGLLMDEEDGALPVSTDDIESLLEFQIDQIQKYGARVPAEIKAKFHAMLRDSHVVPSLSHYLNFSDAWRSGDYPSAFDYLHRYFDYTMQNRDRLFYHYALMNLAIVQSDFGCHKEAMATMLETISTARENKDNTCLNFCLNWFYHFGRAHPDLVQDLEANSMIGSGKEALAFLRAKAKETGMLVLRSSALLSEAKLNMANGESIAGAMEHLVRSSHIIVERNMKSLIGSQLSVTTSLWDRLGISYLSTMTSEVFLRVHAPSACFDDELKMVCRLAGTFAGKGKYNEAFAKLEDGIDKNLLRAAKPNQYWHLYRGLVKLRRDLHHNDLDTAETLLAQLLQIGSEELDPDVVFIIDSLHIEALIRRKDFDAAYEKIERLIAKFRDDHRDLSLRIRLLLAKAHLFDCMGRPERGFSITMRAASLAWRARLLTLLWQAVGALANILNAMGEFTAAVQLVEAVLPRSMESENAFNTGILYSILADARMGQAGKAAKARQAMTTTGETTGAAASLMSNKKIDLFTKAHEALECAFNHFSAAEDLEKQCETLAKRATLMKVLGDHARAEEYAARYMALKRQSSSGEHSSVWSTDTGTP
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).
Subcellular Localization:
Cytoplasm.
Sequence:
MRSLAVVVPKPDSQRAIDGLEDEGVYDDRRKVREHDADHVELPVTAEPDAVPFERAIAQADPDPRAPDLGDRLRERGWSAAERERAPSSWAVLGSVILADFTDCPRPGEVGAALLELHREADTVLDRGDGVAGEHRTPDVSVVAGDGDTETVHVEHGTRYALDLAAVMFSPGNKAERARMGDATGPGERVLDMFAGVGYFALPMARAGATVTAVEKNPTAFRFLAENAQLNDVAETLDTILGDCREVDAPADRIVMGYYDALGGGPVGDAASTPGYLDAALDNLVSGGVLHAHSAVPEAELWERPLSRLRAGCQRAGRPAPTVLDTRRVKSHSEGVFHVVIDARVP
The following text describes a protein:
Function:
Required for normal Golgi function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MASSAPQPSVPGAAEPGTSADATTATTPATSRTGSTAASAGTDPSATAQHPAPGSATPATDTIGRKVEKVLQAHSGLLRAVPGQDDLVTSLAGLDGLLEDNTKHARNNLRSKIEQQALVANQQFITVFSSVFEALAGVETELAGMTSACKQMTERLAKAKSETSALVTQTNNLKQAQDQAELRRKLLDAFTARYQLPPDDKAVLLGDRPFDMTFFSALERVQAIHADCRRLLRTNHQRAGVDIMDDMANIQDRAYERLYHWTQNACRGLTTEHVDNSKRLNLAFLALRSRPVLLQYSLNELATARRNARVRTFSDALTFGGPNGSPPPIEMHSHDPLRYISDMLAHVHQTLLAERDLLRTIVGTDRTVQQGAGSNHAMTGEQLRPFLYLATRCVMMASSSLRVGEALDAIAEGLTRPFRMRAEAVLSALQSDIVMAYKVAALLEFYRQSSQELIKLDRTSSLAEVIQELHAKTLKIFFNALEIRANDLLVNVDVAPASLSPPDSLVRIMSTVREVLDAQATSYGRQGDDGAQELEKAAYMLNCFYHIQTVLTLYDSTHRRLEVIESEMERHIDTLMVVVTTAPMLVNAEGEPVAAMAAEPRFPDRFICPFPHRCVGEDCRYKPMMRAPALRPMTFSWYPASCDDCRCVADNRYANPHGFSFVFTVSTGHSGTGFLGNEAVWAHALRRPSLEGTPVLVFHERHDRRNMLPNIQQRWNVCDVAWTFVVEDMVPFMEQQLLAKNRSIFFSSGHDMTVGLLPALVSYLGPAVSLVRVRRDRVRVAKSFTISVPLGPEAQRCFFCINPDSLLNRCPWRDRQAFAQLSSFQRFLHASDEMECQWQSLRHSFPHQRTFVLNWTTSISEEEMQALAYFVGELQPLSPSAEDLPLLKWIKNQHHRSRALNTSVPQDFQVELAQHAQALGVTLTHCNNMTCIPSPNSSVRGEAGTI
The following text describes a protein:
Function:
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MHAPVWGPQLGNLFNHSCLIANRLRAFSSSAYSNQSRGGLPRFYSEKLPPSKDGVVRVKGDEFWHMTRVLRLTVHDRVELFDGKGGLVEGCIQSVDQTGLDIVALENPKSVSPHSTQWRIYAAFGTLKGGRADWLVEKCTELGACSVTPLLTERSPSISENRVDRLQRVSFAAAKQCQRLHEMVLNPPAKIGALLPLVKNSKLAFIAVAEAKPVFSALSSIKKESAGLMIIGPEGDLTEKELNMILEAGATAVGLGPHRLRVETATVALLSALMLWGDNQETSKV
The following text describes a protein:
Function:
Involved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source. Indirectly activates the PP2A phosphatase SIT4 via interaction with its suppressor TAP42. This interaction is enhanced under nitrogen limitation conditions. Also has a role in regulation of NPR1 in response to nitrogen limitation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSKRNTPPLRSSGINTIQINAAREMHAQTVRARRMPMPTSGITTPSVQPTAAPATPPRHICNNPNNPQCLHCGSVIIPSPRATLPLEDNPSISINDWTISSRKKPILNSQELDIWENEKLKGLTLPEMIFGNNYIRIENSKQHWSIEFNALDALKEVQLQDSGIRVAYSNDWINSKKRQNSTNGAQRFTNDVNDDSLNIIHKYDWTYTTRYKGTESSPESKFRLDNDQKLPLDKLAVHDKILFYDDMILFEDELADNGISILNVKIRVMNERLLLLSRFFLRVDDVLVRVYDTRIYVEFDENVVIRESKEFEGKYQDVLAKHRLSQSHDPKAALRDSNWVAQNTPMIKRQCEIIQF