lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May contribute to the regulation of cell proliferation.
Subcellular Localization:
Cytoplasm. Mitochondrion membrane; Multi-pass membrane protein. Nucleus.
Sequence:
MWLQINFPVKHELQHISDLYTTLRTLRTHLPRPRKGIEPVLIPNTMADAATPPFSLTRPSQYDLSTYLGRVKQFYRLTDPRTLLATDTEFEQAKSWMDRFRAGDRPAGVSDGQLWRARQLVEATVHPDTGEKVFPLFRFSAFAVANLPICALLLYPTTNPLFIMGAQWVNQTYNVAINYANRNASSEMSMTTLAGAYSAAVASSCALALGTQAVTRRIFAGKPMTGATQAITRSLVPYIAVVGAGIVNLVCIRQKELFEGVTVFDGEGRELGKSVKAGEDAIFKCSIARALYVPKAPCNPPTHAREVSDPYQTNSPLTLLVSLLQPGSIRRWTIPLVMPPLIMAKLSQLSGLRGSPRLQTVTELGILGLMTLVFVPPALAVFPQRDSLPVDKTLSNPVVFSFKETLLLFFFLSLSLSLSLSLSLSLSLSLSLFLSAQADLSALEAHCRQKNMSALWLDVKLQHAALVETAGKLGYELHHAHHGTIMLYKWLRDGECLIPPFATHQVGVAGFCTNEKNEVLVIKERHSSVNGYKLPGGLADPGENIDAAALREVQEETGVQATFHSLLAFRQQHGMRFGISDLYFVCRCTAAEAVISHCPVEIAEAKWMSIDDYCLQTSHMNALIARAVQAELEGHNPISRACDIAQFELPSVVRRDLTYRLFLPDTAARHLQVDDPWHGQPHEKIERF
The following text describes a protein:
Function:
Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found (By similarity).
Subcellular Localization:
Secreted, cell wall. Membrane; Peripheral membrane protein.
Sequence:
MNLLGKMIYVEGFMMIMATLLVSMSYGHRAMINDVAEAPVFDDVVSPNGLDSSWYDARATFYGDIHGGETQQGACGYGDLFKQGYGLETAALSTALFNEGYTCGACYQIMCVNDPQWCLPGSVKITATNFCPPDYSKTEGVWCNPPQKHFDLSLPMFLKIAQYKAGVVPVKYRRISCARTGGVKFETKGNPYFLMILPYNVGGAGDIKLMQVKGDKTGWITMQKNWGQNWTTGVNLTGQGISFRVTTSDGVTKDFNNVMPNNWGFGQTFDGKINF
The following text describes a protein:
Function:
Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the amination of UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronic acid (UDP-3-oxo-D-GlcNAcA) to UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronic acid (UDP-GlcNAc3NA), using L-glutamate as the preferred amine donor.
Sequence:
MIEFIDLKNQQARIKDKIDAGIQRVLRHGQYILGPEVTELEDRLADFVGAKYCISCANGTDALQIVQMALGVGPGDEVITPGFTYVATAETVALLGAKPVYVDIDPRTYNLDPQLLEAAITPRTKAIIPVSLYGQCADFDAINAIASKYGIPVIEDAAQSFGASYKGKRSCNLSTVACTSFFPSKPLGCYGDGGAIFTNDDELATAIRQIARHGQDRRYHHIRVGVNSRLDTLQAAILLPKLEIFEEEIALRQKVAAEYDLSLKQVGIGTPFIEVNNISVYAQYTVRMDNRESVQASLKAAGVPTAVHYPIPLNKQPAVADEKAKLPVGDKAATQVMSLPMHPYLDTASIKIICAALTN
The following text describes a protein:
Function:
Probable mitochondrial DNA endonuclease involved in intron homing.
Miscellaneous:
MISCELLANEOUS: This protein is coded in group-I intron 1 of cox1.
Subcellular Localization:
Mitochondrion.
Sequence:
MKPQTKLSENSSRCEKVLYSEVITQLIYFLTSKKITNLGKIRLVKSIRDSFLSQLENILCFFLVYRTTYSFGVCLMKRFLFNKFFNRHPFTRVKSCFSSSSPSKFSFTQWLVGFTDGDGCFSISKQKIKNGKNKWSLTFKLTQNLYNYRILYFIKRNLGIGSLYKESSTNTVIYRLRRREHLKKIIDIFDQFPLLTKKYWDYYLFKKAFLILEDANLNSFEKNSKLEEIRIEKKSLKQYSPVNLEKYLTKSWLIGFIEAEGSFYLLQKSPVRIIHGFEITQNYEQPLLAQISEFLFNSQISPKIKSKKNSLITNYSLSTSSKERMLFLSSYFENCFKGVKSLEFKIWSRSLRKNYNFEQLLRARDLIRKLKNKYSRGSQHPKDK
The following text describes a protein:
Function:
Positive regulator of Notch signaling. Maternal neurogenic factor involved in Notch signaling-dependent neuroectodermal specification during early embryogenesis. Functions cooperatively with amx/TM2D3 and amrt/TM2D2.
Miscellaneous:
MISCELLANEOUS: This protein is named 'biscotti' after the almond flavoured Italian biscuits because of phenotypic and molecular similarities with TM2 domain-containing protein almondex.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MFPVLLLLLFFFAKETHQINVDCNELQMMGQFMCPDPARGQIDPKTQQLAGCTREGRARVWCIAANEINCTETGNATFTREVPCKWTNGYHLDTTLLLSVFLGMFGVDRFYLGYPGIGLLKFCTLGGMFLGQLIDIVLIALQVVGPADGSAYVIPYYGAGIHIVRSDNTTYRLPRDDW
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
Sequence:
MWYRPTPWDVLELEWCPRYLWLSKRHGVPMTPNMAAGRGAEAGLRRFLAKALGAEPKPVYIDAGWAHGVVDILVKRVAASPVEIKTGLPRREHKWQLYAEAYLVKAAGCAVYTGYITYGEKIYRLQISKAELKAAETLLVKAAEVIEGPPPPPVKTGKCAYCQYRAICTPT
The following text describes a protein:
Function:
Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication (By similarity).
Subcellular Localization:
Host nucleus. Note=The protein is present at discrete sites in nuclei, called replication compartments where viral DNA replication occurs.
Sequence:
MDFFNPFIDPTRGGPRNTVRQPTPSQSPTVPSETRVCRLIPACFQTPGRPGVVAVDTTFPPTYFQGPKRGEVFAGETGSIWKTRRGQARNAPMSHLIFHVYDIVETTYTADRCEDVPFSFQTDIIPSGTVLKLLGRTLDGASVCVNVFRQRCYFYTLAPQGVNLTHVLQQALQAGFGRASCGFSTEPVRKKILRAYDTQQYAVQKITLSSSPMMRTLSDRLTTCGCEVFESNVDAIRRFVLDHGFSTFGWYECSNPAPRTQARDSWTELEFDCSWEDLKFIPERTEWPPYTILSFDIECMGEKGFPNATQDEDMIIQISCVLHTVGNDKPYTRMLLGLGTCDPLPGVEVFEFPSEYDMLAAFLSMLRDYNVEFITGYNIANFDLPYIIARATQVYDFKLQDFTKIKTGSVFEVHQPRGGSDGGNFMRSQSKVKISGIVPIDMYQVCREKLSLSDYKLDTVAKQCLGRQKDDISYKDIPPLFKSGPDGRAKVGNYCVIDSVLVMDLLLRFQTHVEISEIAKLAKIPTRRVLTDGQQIRVFSCLLEAAATEGYILPVPKGDAVSGYQGATVISPSPGFYDDPVLVVDFASLYPSIIQAHNLCYSTLIPGDSLHLHPHLSPDDYETFVLSGGPVHFVKKHKRESLLAKLLTVWLAKRKEIRKTLASCTDPALKTILDKQQLAIKVTCNAVYGFTGVASGILPCLNIAETVTLQGRKMLERSQAFVEAISPERLAGLLRRPVDVSPDARFKVIYGDTDSLFICCMGFNMDSVSDFAEELASITTNTLFRSPIKLEAEKIFKCLLLLTKKRYVGVLSDDKVLMKGVDLIRKTACRFVQEKSSQVLDLILREPSVKAAAKLISGQATDWVYREGLPEGFVKIIQVLNASHRELCERSVPVDKLTFTTELSRPLADYKTQNLPHLTVYQKLQARQEELPQIHDRIPYVFVDAPGSLRSELAEHPEYVKQHGLRVAVDLYFDKLVHAVANIIQCLFQNNTSATVAILYNFLDIPVTFPTP
The following text describes a protein:
Function:
Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.
Sequence:
MKRGLILTLCKWLLACVCLAIATVAAASEHIKLQLKWHHQFQFAGYYAAQQQGYYRDEGLDVEIIEGSKDRPPLQQVLSGQADYSIGDSEILVSRVAGKPVVALAAVFQHSPYVMLSLNESGIYQPEDLIGKRIMMSGDQGGLQFKAMLLKRNIDIRQMTILPHSWRLQDLIDGKVDAISAYAMDEPVQLQQMGYSPAIISNQGYGVDFYGDILFTTERELGMHPER
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MAIARTGVYVDDYLEYASTLPAELQRLLNTIRELDERSQSMINQTGQQTKYCLGLASQSSKKGNSNNSCSYYYNNNNNSQEDEVAIEKMLKDIDSSQDNALSLCTEKVLLARQAYDLIDSHVKRLDEDLNNFAEDLKQEGKIAPDEPAILPPLPIVPKSEKRKPFYVTPQSKRMDYREREWDRERDRDFELMPPPGSHKKEFSAPVDVDQPIDPNEPTYCVCHQVSFGDMIACDNENCQGGEWFHYTCVGLTPETRFRGKWYCPTCKLLPECQ
The following text describes a protein:
Function:
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
Sequence:
MTTMTTAAAKAAEPTRTTAIASLHLLAELEGHSSRAWHLAWNPRMPILASCSGDKDVRLHAYSFVSTTSAQGASTCKHPSFNLREVIPTGHQRTVRQVAWSPDGKILATASFDSTVGIWERIQDIDGSSELQGNTDASGPVVLSNGGAHVDEPEWDCVGTLEGHESECKSVAFSYTGGVLASCSRDKSVWIWEVQPDAEFECLSVLMEHSQDVKVVAWHPNDEVLASASYDDAIKLYIDDPSDDWFCYTTLTGHESTVWSISFSPCGNYLASASDDLTVRIWRRLDADQCEAHGLRPEGKMAGRRGEKWIAVNILNGYHDRTVYSVSWGVDKTSTRPGNLGRIASGGGDGRICVYEVTASDDEKSLQPKVELIAKMERAHASADVNCVSWAPESLNARGGTTAKIEQLTDEGETLNKGGQHASHELMSDMLASAGDDGSVKVWTLASSAYAATSK
The following text describes a protein:
Function:
O-acetyltransferase; part of the gene cluster that mediates the biosynthesis of pyripyropene A, a specific human acyl-coenzyme A:cholesterol acyltransferase 2 inhibitor. The first step of the pathway is the synthesis of nicotinyl-CoA from nicotinic acid by the nicotinic acid-CoA ligase pyr1. Nicotinyl-CoA is then a substrate of polyketide synthase pyr2 to produce 4-hydroxy-6-(3-pyridinyl)-2H-pyran-2-one (HPPO) which is further prenylated by the polyprenyl transferase pyr6 to yield farnesyl-HPPO. The next steps consist of an epoxidation of farnesyl-HPPO to epoxyfarnesyl-HPPO by FAD-dependent monooxygenase pyr5 and a cyclization of the terpenoid portion by the terpene cyclase pyr4 to yield deacetyl-pyripyropene E. The 2 cytochrome P450 monooxygenases pyr3 and pyr9, and the 2 acetyltransferases pyr7 and pyr8 are involved in the conversion of deacetyl-pyripyropene E into pyripyropene A through several cycles of oxidation and acetylation steps. Pyr7 acetylates deacetyl-pyripyropene E to pyripyropene E which is oxidized to 11-deacetyl-pyripyropene O by pyr3, which is in turn acetylated into pyripyropene O by pyr8. Pyripyropene O is then oxidized to deacetyl-pyripyropene A by pyr9. Deacetyl-pyripyropene A is finally acetylated to pyripyropene A by pyr8.
Sequence:
MSVQTTYSPVNQDEQVHDGLASRHVSCEGAPSDDSPYALSSLDHNPLGINVSFLLCFHAAQPEEGIRVLEDGINQLLKAHPFLAGDVTRPTRLSQRTNTMQIEPDAPESLLKIPMLQIRHHPATSIEELESKRLLPGAEEQEIIRQLAPLPIDMDLSLPQRPVLRFQANIMRDGVILAMTFHHAAMDGAGAARVLGLLADYCRDPAAPSVGVIPDRQLRSQIDRLATGCSPSASRADFSQHYCGLGDWAALLAENWPGFLQARATELVTWRLTIPGFKVQYLKGACNALLQGQTSALAGGTLTPTILSNNDIVSALMAMILRQAGQLAGKSTELSIAVDMRPSFHAPAFNNYLGNMVLLTYTPIPAAKDQAPVDGPRPPTELRQEDLEELTGIAARIRQSLLKVDAEYIQGVLSHLHSQTDWANIGFRGVPIPLSSFRNFEMIGLDFGETLGSQPRGFQLHLPVLGGMCFVLPKRQDRTEPWDLHLTLHRDDVSRIANDPLFRWAAGEHF
The following text describes a protein:
Function:
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
Subcellular Localization:
Cytoplasm.
Sequence:
MEEGPAVGTLSREVSTEEAEPLGAAWSGDSGHVSQSHSSASGPWDDDGPEDAPGRDLPLLRRAASGYASSLLPSAGPRPEVEALDASLEELLAKVDEFVGMLDMIRGDSSHVVGEGVPRIHAKAAEMRRIYGRIDKLEAFVRMIGSSVARMEEQVAKAEAELGTFPRAFRRLLHTISVPALFRSAPSGPQRAAYEPPVLFRTEDHFPGCGDRPQL
The following text describes a protein:
Function:
Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.
Subcellular Localization:
Cell junction, adherens junction. Cytoplasm, cytoskeleton. Photoreceptor inner segment.
Sequence:
MGCFCAVPEEFYCEVLLLNESKLTLTTQQQGIKKSTKGSVVLEHVFRHINLVEIDYFGLRYCDRNHQTYWLDPAKTLAEHKELINTGPPYTLYFGVKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQAPSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHFKETQFELRVLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSLSRKLSKFGSISYKHRYSGRTALQMSRDLSIQLPRPDQNVARSRSKTYPKRIAQTQPAGSNSINRVTANMENGENEGTTKIIAPSPVKSFKKAKNENSPDTQRSKSHAPWEENGPQSGLYNSPHDRTKSPKFPYARRRNPSCGSDNDSVQPTRRRKAHNSGEDSDLKQRRRSRSRCNTSSGSESENSNREHRKKRNRIRQENDMVDSAPQWEAVLRRQKEKSQADPNNRRSRHRSRSRSPDIQAKEELWKHIQKELVDPSGLSEEQLKEIPYTKIETQGDPIRIRHSHSPRSYRQYRRSQCSDGERSVLSEVNSKTDLVPPLPVTRSSDAQGSGGSTVHQRRSGSKDSLIEEKSQTSTSNLTGKHTAKTIKTIQASRLKIET
The following text describes a protein:
Function:
Inhibits pectin methylesterase (PME) from flowers and siliques. Inhibits PME from leaves.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Domain:
The N-terminal alpha-hairpin extension is required for pectinmethylesterase inhibitor activity.
Sequence:
MAANLRNNAFLSSLMFLLLIGSSYAITSSEMSTICDKTLNPSFCLKFLNTKFASPNLQALAKTTLDSTQARATQTLKKLQSIIDGGVDPRSKLAYRSCVDEYESAIGNLEEAFEHLASGDGMGMNMKVSAALDGADTCLDDVKRLRSVDSSVVNNSKTIKNLCGIALVISNMLPRN
The following text describes a protein:
Function:
Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.
Sequence:
SPLISVSQITTSGLSLLFQTAAAMRYLVRSKGGDNRLQHRVLASVFYEASTRTSCSFQAAMMRLGGTFLHVDGGKGGNTSASKKGESLDDTIRCLECYTDVTVLRHPTTGSVGQVALGGGTVKPVINAGDGVGEHPTQALLDYFTIWDELGLSLNPEDWRDDRDDYGHKKKHKGDLIVVMLGDLKHGRTVHSLAKLLARSNLKHELVLRYCSPASLEMPSYVQEYVSGCDNVKQEEYTDMAEAVKGANVLYVTRVQKERFEKEEDYEKVKGAYVVDTELMEVAPSDMIVMHPLPRVDEISTDVDSDPRACYFRQMENGMFTRMAILALVLGKP
The following text describes a protein:
Function:
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MDELLPVALPIGRPGINSDLEEDHGRAPATAEEYLLRVRNEARQTPDVVVAHLDRDTLKSKQTVVVSNSTGFSPAPRGFAPTTMWQRRQSASFSELRQRLAGVTARIAGERKEKMELPKYKDEDSWCQFCLGRTFLDRMRAKQGRPPVDDEEENICGQVTMTTPVPPLVTVISSLDQAMVQKLLEYHVEWLEMLGFSIAQGCWLFALLSCFEKPLLADSTATIRTLSRHCATLRAVMDSNTEENLVALNLIISIIARYFDQTDLADNG
The following text describes a protein:
Function:
Promotes tail assembly by creating a scaffold for the tail tube proteins. Tail assembly proteins G and GT probably wrap the linear tape measure protein to create a tail assembly scaffold. This allows the polymerization of the tail tube protein, during which G and GT are released, therefore they are absent in the mature virion. The tail assembly protein GT is produced by a rare -1 ribosomal frameshift. The ratio of translated G/GT is about 20, and this ratio is important for proper tail assembly.
Miscellaneous:
MISCELLANEOUS: [Isoform Tail assembly protein G]: Main product of the GT gene, representing 96% of the translated protein.
Subcellular Localization:
Host cytoplasm.
Sequence:
MFLKTESFEHNGVTVTLSELSALQRIEHLALMKRQAEQAESDSNRKFTVEDAIRTGAFLVAMSLWHNHPQKTQMPSMNEAVKQIEQEVLTTWPTEAISHAENVVYRLSGMYEFVVNNAPEQTEDAGPAEPVSAGKCSTVS
The following text describes a protein:
Function:
Positively regulates keratinocyte differentiation by inducing genes associated with epidermal differentiation.
Sequence:
MSQQKQKQCAPPQQCCPPPQQRCPPPQQCCPPPQQCCPPPQQCCPPPQQCCPPPQQCCPPPQQCCPPPQQYCPPPQQTKQPCQPPPKCQEPCAPKCPPPQQCQTSKQK
The following text describes a protein:
Function:
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular Localization:
Membrane; Single-pass membrane protein. Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MTIDRTFPIFTVRWLAIHGLAVPTIFFLGSISAMQFIQR
The following text describes a protein:
Function:
Component of the survival motor neuron (SMN) complex that catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Nuclear receptor cofactor for the ecdysone-regulated processes of molting and puparium formation. Acts downstream from ecdysone biosynthesis and release to control the expression of specific ecdysone-regulated genes such as Eip74EF (E74). Essential in muscle and neuronal tissues for motor function, including climbing ability and flight.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, U-body. Nucleus, gem. Note=Shuttles between the nucleus and cytoplasm at different stages of development.
Domain:
Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which is usually essential for the association with nuclear receptors.
Sequence:
MNSQVMYHNVPTPPGNVSLAAAAPDGGLLYAGIRCINYISAPPANGEQPQVVTMSTRINILALDVSPMWGLGNGGPTKPFAIVGDDLSVQVWDCALGEAVIGHKAHQHQHEARDVRVVHHTTNSVLMSYLANGNILSMDASDLVIYCVASNTYCRRSTFISPRNHQLTMVRCSPYNDNLFAVGTAMGNVLVCDLRKMNIVYKFHGHKAPICGLAWREVPAAEDEKTNNLALSAEEWRSRNGGQEEKPKTKPPPLTKSKAAESDDPFDIYNFDHLEYEFGAPIAERRRKSSEDCGGEFVGLEKPAGAAVLDFVEACESVKAELLASRQEDKTQHVEVTLHDCEPTKPTGPLSDASTISNKNDASDSTEGSLEVIQYSSSSDDAVIVDGEAAKPKREVLHHIYHQAEVHASGTPQTKSEPQSNLQVVPAISAETISLTSVNSTHLETLLVSIDGDEVMMIWNTNTGAHAGKNYSKSKTAGKLNNVYWLNNHVIVSLSRHQLFFWSVEFERKMLRYKISKDKSHSCHLQDIVSFACDSSKEMIWLCRNNRQIGMMNPKTGRMADFYGTVAFGVRAMAECPDDMNKIALGCSDRRVAFFDISKLTTSCLPIDSVYVSSNVYCLAWSPNCLELAFGTFDGTVGILDVERMKVKTHLRTPHKKEVYSLVWQDHFIYFIVNRVLGFFDLRKSKIEPTIVNCISRPSYLSIRDSFLFVGTDDGLLQIHERDSGMEKSWSPFIRQSALFARYVTDIAWCPLDSNKFAVSGNDRSVYVMEFQPTERNWKTLHTFTANTEKASITSMRWSHTQKHLLLTFHIEGKVCLWNCNAPEKPPLTITYHCPMWCGMFLPTNENIIMCSGKALSVELIDIKDALEGDEKSICPKVDALLNVKWASKSLTQPYAPVLTAAEKKRQRRDQRKAAAKLEVDVANKDQKKIQESVTAVIDNPTNDKCTQETPVEEMLEALSLDKEQNNRSAKECPKCKEQSPDSFTHSRTCLYLTQKELNKSALEKLAIVLTEDSAKIDKSVLISKLFSSKVMAKELIATELTNLKHSNTKDIAPLCLAMSTFKLREELEQHIANKTLTERHVSLAPSVSFTLWQDCCRAYAKQMEEKGYIMHAATYLFSQGMQSEAIKLFLANEYYKEALVHARICLPATDPLIKTVINNWLEHLEGTGNFAAAALICVLDNEMLRGYSYLRKYRNCTPEIADLMDQIKRIGQLGGVLDGCAPNEPIHNGSTAEH
The following text describes a protein:
Function:
Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
Subcellular Localization:
Secreted. Bacterial flagellum.
Sequence:
MRIGGLSGLDTDNMIKNMMKPYTMRVDKMKQNAQIVKWQQDAYRSVISGISDMTKKYFDVLNGDNYMLSSKNFSSLKPSGIPDTSTIKINTGSGAVSGNYSLKVIELASKAEAISDKAINIKTLSEGDYGIKIDASNSKIVIDGNEITLSESKYNNASDIAAEINSKINEDGSTLKDKVKAVVKDGSIKIENLFKIDDTNKELKVTVDGKEYTAELAKGNFTLEELTDSINGKLEVAKDADGNVLVEDKGVKASLSADGKSIEFTGTTAQPNYLVAGVNLGGTTGGTGITGTDVTVAGNSITYAKEIIAGFNDTFNIQIGTDSSKQVKLAAGTINSIDELKTKLNDAFTTAGLNTTLTATVKDGKIVLSSNSDKQVIITGESGKSATSLLGLSDRYEMSMSTNEKMSNIVNEAVEFEINGVNFKYDFTSIGAERDKTISQILADILDKANVQASYSEITKSFTLRSKEEGATQNIKCEDKSGNFVSSILGSSTTAKGKDAKIELKTPNNSTATTIIKPSNNFTIDGVNYNIAGAKKDEEISFSLDGNVEDSFNKIKGFIDDYNKLIDELQKKTSEKKYRKYEPLTEEQKKEMKENDIKLWEEKAKSGILRNDSNIENMLSTLRRAFFDSVEGAGLSLKELGLTTSKDYQEGGKIVFDQILDKNGNNGEARLKKLLKEEPDKVFKIFSQESTSYPSYSADLTLTERQIRNKEEGIFQRINDIFKDYTRTSRSASGKRGILVDKAGIEGTVSAIDNILYKDLEKREKAIQDMELKLIERENKYYIQFAQLEKYINQANSQASWLAQQLGGGMS
The following text describes a protein:
Function:
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1 (By similarity).
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition.
Sequence:
MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMATGSWDQTVKLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFLNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYEMDDTEHPEDGIFIRQVTDAETKPKSPCT
The following text describes a protein:
Function:
Activates the ARF proteins by exchanging bound GDP for free GTP. Plays a role in maintaining mitochondrial morphology, and in the turnover of mitochondria through mitophagy.
Miscellaneous:
MISCELLANEOUS: Present with 2940 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Endoplasmic reticulum. Mitochondrion. Note=Soluble and partially membrane-bound.
Domain:
The SEC7 domain is sufficient for stimulation of nucleotide exchange on myristoylated yeast ARF2.
Sequence:
MHDVPMETVLAVNPATMIVKECINLCSAMNKQSRDKSQTSVAALLGGGSDIFLSQSDSFVDSFHNLPTSSYHDPLISGLVQLRLKINDLKGLDSLNALELLKPFLEIVSASSVSGYTTSLALDSLQKVFTLKIINKTFNDIQIAVRETVVALTHCRFEASKQISDDSVLLKVVTLLRDIITSSFGDYLSDTIIYDVLQTTLSLACNTQRSEVLRKTAEVTIAGITVKLFTKLKLLDPPTKTEKYINDESYTDNNLKDDIIGTTTSDNDLSSTDDDSAVADDNKNEKPVQQVIREQENDEETAEKAENVEPNYGITVIKDYLGLLLSLVMPENRMKHTTSAMKLSLQLINAAIEISGDKFPLYPRLFSLISDPIFKSVLFIIQSSTQYSLLQATLQLFTSLVVILGDYLPMQIELTLRRIFEILEDTTISGDVSKQKPPAIRELIIEQLSILWIHSPAFFLQLFVNFDCNLDRSDLSIDFIKELTKFSLPAAAVNTSNNIPPICLEGVLSLIENIYNDLQRFDRAEFVKNQKEIDILKQRDRKTEFILCVETFNEKAKKGIQMLIEKGFIDSDSNRDIASFLFLNNGRLNKKTIGLLLCDPKKTSLLKEFIDLFDFKGLRVDEAIRILLTKFRLPGESQQIERIVEAFSSKYSADQSNDKVELEDKKAGKNGSESMTEDDIIHVQPDADSVFVLSYSIIMLNTDSHNPQVKDHMTFDDYSNNLRGCYNGKDFPRWYLHKIYTSIKVKEIVMPEEHHGNERWFEDAWNNLISSTSVMTEMQRDFTNPISKLAQIDILQYEKAIFSNVRDIILKTLFKIFTVASSDQISLRILDAISKCTFINYYFSFDQSYNDTVLHLGEMTTLAQSSAKAVELDVDSIPLVEIFVEDTGSKISVSNQSIRLGQNFKAQLCTVLYFQIIKEISDPSIVSTRLWNQIVQLILKLFENLLMEPNLPFFTNFHSLLKLPELPLPDPDISIRKAKMSRSLLSTFASYLKGDEEPSEEDIDFSIKAFECVKASHPLSSVFENNQLVSPKMIETLLSSLVIEKTSENSPYFEQELLFLLEISIILISEASYGQEFGALIADHMINISNLDGLSKEAIARLASYKMFLVSRFDNPRDILSDLIEHDFLVKNEIFNTKYYESEWGKQVINDLFTHLNDVKYNERALKNVKFWNFLRILISAKDRQFAVYTFLEKYIQNGDIFVDDGNFMNILSLLDEMSCAGAVGTKWEQNYENSVEDGCEAPESNPYRSIIDLSSRSINITADLLSTVGRSNSALNKNEIIAAIQGLAHQCLNPCDELGMQALQALENILLSRASQLRTEKVAVDNLLETGLLPIFELDEIQDVKMKRITSILSVLSKIFLGQLVEGVTSNETFLRVLNVFNKYVDDPTVERQLQELIISKREIEKE
The following text describes a protein:
Function:
May play a role in DNA replication checkpoint via regulation of hsk1 or may act downstream of hsk1 in an S phase regulatory pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSTLSYVSPDALKGWLMESPNEISIIDVRDYDYEGERIPGSVRIPSDTFLASVDQHVDDLMKKRSLIVHCTYSQVRGPKAARVLSEILRNRITESKEKLSLSQKEKLFQNLPTVYILHGGFSAWKRRYGGQQGLIEYD
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB15 may act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MAKQYDVLFRLLLLGDSGVGKTCLLCRFTDNEFHPSHISTIGVDFKMKTLEIDGIKVRIQIWDTAGQERYQTITKQYYRRAQGIFLVYDITSERSFQHIMKWASDVDEYAPEKVQKILVGNKSDEQEKRQVATEQGDKLAKAYGMDFFETSAFTNHNITESFTRLAELVLQANKKDLDLLGGSLNDELNLADLEEQEGLCNVSDDTRKSCWC
The following text describes a protein:
Function:
Subunit of STT3A-containing oligosaccharyl transferase (OST-A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.
Subcellular Localization:
Endoplasmic reticulum. Membrane; Multi-pass membrane protein.
Sequence:
MTVYALVTVSYFLITGGIIYVVIVEPPSRPVPFLAYRVNGQYIMERLASSFLFTMGGLSFIILDPLSAPKIPKLNRFLLLVIGFVCVLLNFFMAGVFMRMKLPGYLMG