lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Appears to be mainly nuclear. Translocates to the nucleus following adenylyl cyclase or MAP kinase activation.
Sequence:
MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHGGSLPNVSQLRSSASEFQPSFHQADNVRGTRHHGLVERPSRNRFHPLHRRSGDKPGRQFDGSAFGANYSSQPLDESWPRQQPPWKDEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYGGGGQSAWPAPYMGFCDGENNGHGEVASFPGPLKEENLLNVPKPLPKQLWETKEIQSLSGRPRSCDVGGGNAFPHNGQNLGLSPFLGTLNTGGSLPDLTNLHYSTPLPASLDTTDHHFGSMSVGNSVNNIPAAMTHLGIRSSSGLQSSRSNPSIQATLNKTVLSSSLNNHPQTSVPNASALHPSLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQGFSRQLSSTSPLAPYPTSQMVSSDRSQLSFLPTEAQAQVSPPPPYPAPQELTQPLLQQPRAPEAPAQQPQAASSLPQSDFQLLPAQGSSLTNFFPDVGFDQQSMRPGPAFPQQVPLVQQGSRELQDSFHLRPSPYSNCGSLPNTILPEDSSTSLFKDLNSALAGLPEVSLNVDTPFPLEEELQIEPLSLDGLNMLSDSSMGLLDPSVEETFRADRL
The following text describes a protein:
Function:
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MSGKITDFFEKKTTTTIDEAENKDNDKELTSTTTTTTTTSTTSKKKVAAAPKKKAAVASKKRKHESSDEETDKEEQQNDDDDDGEEKVENNNNNKKLKNEEKSEEINSTITDNNYYDDIENYFTDKQWKEALSGEFGKAYFKKMITQLNKRYSSKEKPIYPPKNEIFSAFNYAHLEDVKVVIIGQDPYHGKGQAHGLSFSVKKGVSPPPSLINIYKELETDIEGFKRPLKNGFLEPWARQGVFLLNAVLTVEEATPNSHKDFGWADFTDAVLKILSKQDQPIVFILWGGFAQKKEKLFTNKNHLVLKSGHPSPLSIKHFIGCKHFSKSNEFLKSKGIEEIDWKITE
The following text describes a protein:
Function:
Involved in spore wall assembly. May be involved in maintaining genome integrity.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRFQLFIYFYFTIVVIAGTNTIQQFSDAGDRLITSLRNLDNNGTYETLTAEKVPIIEGQIQNISAKYEQHTFILKGLEAVLNYKVKSLDNNERESLEIEYEKVEKALDAALNVSPFEYIKKFKEVSRGKVVNALENLSREQNRITINGGREDEKEKEAREKKKRLDRIKRILTVSLLELGLAQGVADLCAVAPFACLLGVTVGSIGFIFWLALIYNAIQ
The following text describes a protein:
Function:
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Subcellular Localization:
Cytoplasm.
Sequence:
MEYRITGKGVEISEAIKNYLEKRLDKIDRVIYDDDLVSFNVRIEKDGKNQYVVKFNMNLKGNIINVEERHPDIYTAIDFASDALEKQVKRLKERLKNHPHRSSALVETPLEEPGEFSPSDKVSSVKRVSLLNLDLDEAVMQMDELNHRFLVFRNVNTGEINLLYRDENGDIHLIEMAE
The following text describes a protein:
Function:
Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Sequence:
MALVDPDIFNKDPREHYDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKMEPDDDVSTLQKEILMLKSCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDSGEVKLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSSSFHNFVKVTLTKNSKKRPSATKMLSHQLVSQPGLNRGLILDLLDKMKNPGKGLPVEIEDEEPEPPPAIPRRIRSTYRASSLGIPDADCCRRHMEFQRPRCVECRSQADTVLLQPSADFRSTSPRSQLSDSDDDYDDVDIPAPSENLPPPLPPKPKIRSPSDDGSGGVRDDGQLSPGVLVRCASGPPPRIPRPGPPPATRSPHLTARSDPSLWNPAAPEPGQPPLLPPRKEKMRKKMENEKRREEYTLLVKLFNGCPLQIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMIFPGRTTWLYCINNLLMSLSGKTPHLYSHSILGLLERKEVRTGSPIAHISPHRFLARKNMVSSKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLPVFALLTTPGSELPAVCIGVSPGQAAKSVLFHTVRFGALSCWLDDSSTEHKGPVQVIQVKEDMVMVLMDGSLKLVTPEGAPAPGLRTPEIPMTEAVEAVAMVGDRLQAFWKHGVQVWAPDSEQACSGGNTAHG
The following text describes a protein:
Function:
Mediates the cap-independent, EIF4E-dependent translation of viral genomic RNAs. Binds to the cap-binding site of host EIF4E and thus interferes with the host EIF4E-dependent mRNA export and translation. VPg-RNA directly binds EIF4E and is a template for transcription. Also forms trimeric complexes with EIF4E-EIF4G, which are templates for translation.
Subcellular Localization:
Host cytoplasmic vesicle. Virion.
Sequence:
MEQTAAPTAARHATHTNSAQEQPPVSPMNLSANFVAPELFYASNVEKIKSIIRMRSTTRIIDAISRDFELVAFLILSPAHLMQLETTLRCEMKSSIVPIANSDAGFETCAVLKTALDGMKYHFGTTTLEQGWTSMMRHADSCLQESSSSAVAMLQTQVQKVGSLLISGKNRVESCELYVLHLTARAFRTEYGLKGTCFGEHCALLHDLKACVCGTVPKEFLWAKTKKHSMFTIPEWIARTPTDCFMLCLRAIPIFRRCTMAMSLLYWSCVATVNFPSVMAFLFKRQFTKYIAHSFAKHSIYFLMLGIVALLWAFRTYASKNPKIALQARSANEKEKKLMMLLASAVGITYLFDYDIAEALGNSLHKISRLSSYLMDDHQGIASRMFGASYGLQAGDNVEDAVTTIISDLLSVTFQIVEEDTTAGVLEEVSDTTFSSWVSVNTIAGRNMSRPLQYPVNQTYPLTPMNVLLQAQAMVDSDNCWSMVVGHTGSGKSTYLPVQYSNYLAKKLDRRQQILVCEPTQAATENVCSGIAANLGRAVYGRHEGWSRMGDHCIQVMTYGSALQCHAMDPGFISTFDAIFLDEAHDVKEHSLVFESICNNFKSVRKFYVSATPRDGSSCPDATRKFPLTVQQSVCDSYKKFIAAQGGDDLLDVTKYDTVLVFLAGRPECVKAANAWNASITGEKRAFSLSSDNFATDFAMLTERLKTHKTIIFTTNIIETGVTLSVDCVVDFGYTMRPSLDLNHKTLRLERRRVTANERKQRIGRAGRLKEGHAIVCGDEDRSVNVVSPDVLYGAALLSFKHNVPFYMNDTFESSWLEGITKSQADTMTIFKLPIFLTRDLVNSDGSVAKEFLDILKKHQFTTSDIKQAPHSIARHLFPTWASYFALFQSINYGEEKDEIPSNLRHARVPFSISTLSKFDWNALALACEQHRPTVMSSFQGLDQPARVVTLQTNSANILGSIAHLCNMRNNYKALIDSNNHVKQSMATNVMFKWFSSSRITADLDRNLSRCLANLSVVETTISALKQISAGNSQVMASPILQSHLENIIELQSNDMLTDETLSNALGIFNPKTNLFLLLATKGFKLVYVICLLIFINLIYRLLSHWRAWLKNKNDNVNPDALTNTMTVQEGSEILKEVLKMTPAMRREVTKDMKVAVADNNSTFSFVFPDEHIDLEGKGNKYRPREDARLMYSTRDDATFDTWNEKAKEKRKKISDRAEPEMKQPYQKRPYYNFYDLQTDSNILEAIFYTTEGDEFFRTANPNKDMHSVAEKLKAFLDTKPIIGRHQRQLLEETAQVVIKDDKGTAHRMDISTHNPNTLKNNGSGRVGYDEHRGDFRQESPALESPYELEAEFGNSKDEVMLEASTGILLSQVSVDVATRIGRISIGTFNVNCFLYSDWILAPAHFQDRNGAVTIEFPDQTVSTTTDNLNAHGVKRFYGLDLIAIRRPPSLRPEKKLVKAFAITEPVLAQMVFIDSQGIRKFSQSDWIRQEAGSNRWSHKISTQNGMCGCPVLDVGKNRLIGIHVATNRTTGRNEFQPFTREAVDFINGPGNKVPFSPWIFNRPACGYKQGEATFASRTIQNQASDTLSKINNSILGFGSDLKGQLVQPVTPALRTRFEALFGGGSFELVGTMNKGLIDKHTIVGENDNVHDFMREHPTFAWLQGFMDEYAPSVLNYSAYYKDLCKYNRKKHQLSFNPHELRSATAGMIRMLEDAGLTQGDVRTPQQVVSDMQWNTSAGPSYQGKKRDVCAHLSEQEVLHLAETSRQQFLACNSIGIWNGSLKAELRTIEKVEAEKTRVFTASPITSLFAMKFYVDDFNKKFYATNLRAPHTVGINKFSRGWEMLHDKLNRPGWLHGSGDGSRFDSSIDPFFFDIIKEIRKHFLPVEHHRAIDLIYDEILNTNICLANGMVIRKNVGNNSGQPSTVVDNTLVLMVSFLYAYIHKTGDHMLKKLNDRFVFVCNGDDNKFAISPEFDAEFGHDFSPELTELGLTYEFDDITDDICANPYMSLTMVRTPFGIGFSLPVERIVAIMQWAKKGGVLHSYLAGISAIYESFNTPKLFKSVYAYLLWLTEEHGSDILAAMTGTETALPIPSMLDVYRLHYGDSSIELQAADTQTDAQKEEARLAAATKKAADDADAARLRKVEADRVEAARVKKASDDKKARDLTATKVDDGKIVADAGTKRTNAATKEKWSLPETKPVNAGLKLRISMDKLKSAPKSIIEHDNSIALDSEVKKWSDAVRTSLGITTDEAWINALIPFLGWCANSGASDKHAENQTMQVDNGTGALTEMSLSPFIVHARLNGGLRRILRAYSDETVLLLQEHKIVTKWAMKHGASAHAAYAFDFFVPRPWMNPQDIEVAKQARLAALGTGTYNTMLTSDTTNLRKTTNRRVLDTDGHPELT
The following text describes a protein:
Function:
Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MVLSPPVMRIGHSEGQTEVCYDETGKYILTCGSDGDIRVWQGLDDDDPQSIDVGESTAALAINRGKLFSASDANTVQAYTFPDGQSDGIIARFTAPVSHISLSQDGHKLVAGASDFNIKVVDLGDSSQKVLEGHTAPVLSVAADPLHQYVASSSCDGTLKVWNIDEQSWEKSSVLIPKCSDVSLSKTLCRMDWKPHSGEYLVVPLEKKIEVYERSSWDVVFTLEPEDAGGFVSVVSWSPCGQYLASANTDGTLCFWDIKTKKCVQRSKHKKGLAICGLAWNPHIKHELAFTDVMGQVGVFEDITFSDDKGRLNNQVAEDELVGDLFDDAADEDLLEAVNQATNADIDKDELDALVDDDDDDDKVHEEIRRAKQRLAMLTGDAPSMDGASNVEDTGSISDVTDIAPPVLSAPVPAQVTPMQKPFIPASTPIHLSSRFMKWNSVGIIRCYDTEDESSIDVEFHDTAIHHSLHFDNQNNYTMADLSNDAVLLASESNLENPSLLMCYHFLSWDNQKEWSTSLPKGENIKGLAIGGGWIGVGSDKRLVRLYSTSGIQREIFSLPGPIISMAAHGDKLLVAYHAGIGVPGDQCIGVKLLTVFQKKPELAFEGQLPMSPKTTLAWIGFTAEGTAVSADSGGVIQLFNRKLISWTPVAHTKNHTKAHSDCYWIVGVHEKQQQIRCIACKGAPFPPTLPRPTVTILPLQLPLCELNTEKGQMEETYWRLNLLSQHLGETDNEMIQAKMERDQQDNLMKLFALACRSEREFRAYEVCNLMTSHQSVSLAIKYASRSRRMALAQRLSEMASRLMEEEEEEEEEEEVLLHHDRVIPSNRLAATVNENQTSRVNHLRDSDEESEIREEEEEMETVPTLNLDTKHEKIPSLLPSSQGRRNPFKKQQDRAGSNPRGTNVFDEMKKKSPDTKIQVKQGKISHKIATSNGDVTKPRTQATLFTSKTKQSQETTDTSARNKKKPSAFNFWLSQNRDSLEEESPELGASEIIKVAMQTWKNLSNDEKKEWEEKAAESVTEAIEQDHLPDTKPEKKHPETKQLDKKRKLADNEAEKGEEKRSKPGRPKVMEKDSKKQPLTVATNAKLASFAFKN
The following text describes a protein:
Function:
This protein binds to 23S ribosomal RNA in the presence of protein L20.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASSSATLSLCSTFSAHCNVNSRRSSTILCSLSKPSLNLAKPLTGFLSPSTASTSRTAFTVAPKFAESVVEAEPETTDIEAVVVSDVSEVTEEKAKREEIFAVIMVGGRQYIVFPGRYLYTQRLKDANVDDQIVLNKVLLVGTKTHTYIGKPVVTNATVHAVVESQGLNDKVVVFKYKPKKKYRRNIGHRQPNTRIRITGITGYEEYPASPNVAVGEVNL
The following text describes a protein:
Function:
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MSIICTISGQTPEEPVISKTGYIFEKRLIEKHIINYGICPVSGEVLTLEDLYPIKNEKIVKPRPITASSIPGLLSIFQTEWDSIISEMFSLRTHVNDIRNELSHSLYQYDAATRVIAKLLKEKNGYKEEIENLKKQIFQLKSSNDLDIYEIGLNEELLEKMQNVAKDLLINRKKRKIDNVCSVEQWKDFKNTNEFNIHSSTIPGVTCITLDVNKYKYNYNDDHMKHNFFSGGNDGNVYYVSLNDNKILSKLQGHLKKVNSIISHPSNFICITASNDKTIRIWKGDDNNVHHNDNGDSDSDNNNNNNDNDGSHLNNNEYIYDNYQFVSAHVITKHKDHVTSLALHPLENYFISSSKDSMWILHDLETAKTIKTSKDNPSSFKHLAIHPDGMMFGIAAQDSNIHIYDIKSQEYKATLNGHTKSLNCLSFSENGYYLASSSKDNTVKLWDLRKAQSFQTITLNETPNFISFDYSGKYLSIAVENDIQIYNFETKNQANLIKTLSSHTDIVTQTCFGSTTSYILSSSMDKTIKLWN
The following text describes a protein:
Function:
Catalyzes the conversion of dTDP-alpha-D-fucopyranose to dTDP-alpha-D-fucofuranose. This is a step in the biosynthesis of D-fucofuranose, a component of E.coli O52 O antigen.
Sequence:
MNKVLIIGSGFSGATIARLLAEENIKVKIIDDRKHIGGNCYDERDEKTGINVHVYGPHIFHTDNEDVWNFVNKYGTFQPYTTRLKANAKGQIYSLPVNLHTINQYYKTALSPTEARKLIASKGDQTINDPQSFEEQALKFVGEDLYKTFFYGYPKKQWGMEPKEIPASVLKRLPVRFNYDDNYFFHKFQGIPRDGYTPLFQNLLNHPNIEFELGKKVNRATVEELITSEQYGHVFFSGAIDHFYDYEFGMLQYRTLDFEKFYSEDDDYQGCVVMSYCDEDVPYTRVTEHKYFTPWEEHKGSVLYKEFSRSCDKEDIPYYPVRLVSGNSIWNKYEQKAKEETNITFIGRLATYRYLDMDVCIKEAIECAQLYIKNNKE
The following text describes a protein:
Function:
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Plays an essential role in the regulation of endothelial cell senescence and vascular aging. Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MLAAHRLGMTDGSYAFFNIVLFDSSYFGNIGWERGDADDENAKAAYRALMTFTLHKKKSPVFEEFALDVKERALKEFNFSYDAIGEEVNSFVGAFHDAVLLYAIALNETLADPDADPRDGALITRRMWNRTFEGISGDISIDENGDRDSDYSLLEMTDIENGTFEVVGIYYGAKRLYEPVPGKTIDWPGTVIPPDTPKCGFENELCPATDNSPMTLWIMGAMAIIILSAVVIILFVLRKYRLERELSNMSWRIRWEDISFNNKGDKMRKLGSRMSLASGSVESGTSVWGNNQQIFTVTGFYKGNVIAIKRVNRQRVELNRNVLMEIKHVRDLQHDHVIKFIGACIDAPNISIMTEYCPKGSLQDILENDSIELDELFKYSLMYDIVKGMLYLHNSVIQTHGNLKSSNCVVDSRFVLKITDFGLTSFREPDHAFEPDEEDSYKYYQRRLWTAPELLRLPEIPSGGTQKGDVYSFGIILQEIMYREGVFYIKDVDLMPEEIVKKVANGYKPAFRPTIDRVTCSQEMMTLITNCWKEDSTIRPDYSQLRGTMRKLNKNSENKGLVDTLLSRMEQYASNLESLVQERTEAFYEEKRKAEELLYQILPRPVAEELKKGKPVTAESFECVTIYFSDIVGFTKLSSASTPLEVVDLLNDLYTCFDAVIDNFNVYKVETIGDAYMCVSGLPIRNGDFHAREIARMSLALLHEITSFRIRHRPEERLRLRIGVHTGPVVAGVVGLKMPRYCLFGDTVNTASRMESNGEAMKIHLSNQTKKILELFGTFILELRGEVEMKGKGTQTTFWLKGELKGQNGICDLKYQEITV
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
Subcellular Localization:
Nucleus.
Sequence:
MGVQGLLPVLKSVTDQVHVSKYAGKTVGIDASGWLYKGAYSCPVDLVLGRPTDAYLNFSIQQIKLLQEHNITPILVFDGAPLPAKAQENAARRRSRADWKLKAKKLVQEQDGDADNRAVFSACTRALSVSNDMVMRLIGVLRRMNITFYVAPYEADAQLAFLSRQKIIDVVISDDSDCVPYGVKTVLFKFSQDGWGSELKRRSLGANEELSFVGWVEEMFIQLCVLAGCDYCPSVSGVGIITAYKLVSEYKTPAEVLAALQKQKGPSLPDDFAEHFYSAILTYRHQLVFDPRDSYTYILS
The following text describes a protein:
Function:
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.
Subcellular Localization:
Nucleus, nucleolus. Nucleus. Mitochondrion.
Sequence:
MTMSSDHSLDDIMGSIVVGRRKLSISDFEDDFDIDEITQNAISSATKRSKSTSAVPQNSAVLLPPEFSLSSTFEDDIDAVMAEIRVQKPAKKHNSTQATRVTHDIPFQEPERRPQPVLEASDISKDISDMDDILADIEIQPTAKLRRVKKASQSSPSLSQQIDDMMNQKKLNVDSHKPASAHKQTSSPGVPVFLKHSQQPLLQLQHPRRADLSSSMVQSGVLEDPFCDEINSSPPLQALDSSPYFSQKTSGNLLNLPNLPAFDFSSQTLQRSKSDSLKFNKKLISSFDLEGDLSDTKYGVCDLESAGRPQQLRSESARRQQSREAGQVMSSVSHETNDKPLSSLPPHSSPSRERSLSTPTELLNYNASDVKPTSTPLASSQIEWEPSSRELCGYDVHTLNLRQKAKLKEYGRLSPGDLRDTRVKRFKSAGEAEPREQQPDGDSAVAGVSKNGFANSPRKNESRRAKSESAPKVLQQLDFFNKSNRPQLDAGLKSKGPRKSIQSRLYTTTTHNTLVDVDGEEDGLMTVQVASLSAEQQAIHDLVINGETNIFFTGAAGTGKSVLLRQIIASLRRKYKKSLDKVAVTASTGLAACNVQGTTLHSFAGCGLAREDVDSLCKRIRRNKKARDRWKNVSVLVIDEISMVDARFFDKLEQIAQKLRRNKRPFGGIQLIVTGDFYQLPPVPDTNKDRFRGSYGGNKTNTGMVDSRSAVNSDPEALFAFEAESWSTVIDSTFLLTKVFRQKDPVFANMLNQLRTQSLDQASLDGFLSLSRPLSVPDGIIPTELFPTRREVDRSNFSKLSTLGGKTHTFDALETGSAEREFRDKLLENIMVPKKLTLKAGAQVMMLKNMDPNLVNGSIGVVVGFMSPHNFIAAENAADLDIIREKPSKRPNIYDVSNESELNQLNQLIETGKVVGESSQASEESAFFSSPAQGDSDCVFERLKAFPEDADNATFLKRKLERRKQLEDLAKTNLAAMNGAVYPVVRFRRMDHTFRNVLLHPETFSVENIEGEVLASRTQIPLILAWALSIHKAQGQTLQYVKVDLAKTFERGQAYVALSRATSKEGLQVLNFLPEKVKTHPKVVEFYKTLTTYEDDEPHEVQQENVQPMRAVG
The following text describes a protein:
Function:
Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
Subcellular Localization:
Mitochondrion.
Sequence:
MWRVMRKFSVNALKLSSLCSQHVCFRKPEVMVLSVTQQNSSERNYSSPPGDVKSLRSVINPHISRIRNIGIMAHIDAGKTTTTERMLYYSGYIRTLGDVDDGDTVTDFMVQERERGITIQSAAVTFDWKDYRINLIDTPGHVDFTVEVERCLRVLDGAVAVFDASAGVEAQTLTVWRQADKHQIPRICFLNKMDKNRASFTYAVESIKQKLKTKPLLLQLPIGEAKTFRGLVDVVTKEQMIWKPTSDLDDGKFFEQKPLLESDDPSLFQEVQDARNTLIEQVADLDDEFAELILGEYSENFDLIPSDKLQSAIRRVTLAQKAVPVLCGSALKNKGVQPLLDAITMYLPAPHERSYEFLQWYKDDDLCALAFKVLHDKSRGPLVFIRIYSGSLKPQSAVYNINKSCTERMSRLLLPFADQQIEIPSLMPGNIALAVGLKQSATGDTLVSSKASAVAAARQAGRSAGGEQRNTGDIESLLLAGVEVPEPVFFCTIEPPSMAKQQDLDNALSCLQREDPSLKVKIDPDTGQTILCGMGELHIEIIHDRIKREYGIETYLGPLQIAYRETILNAAQATDVLDKVVGDKRHFVTTELEVRPVSGERTVTKPIIEYAQSVIEVLPKELQEAIENGITNSCVQGPLLGFPVQDIDVTVQSLTVHPDTSDTMISACISRCLQKALKKAGIQILEPLMSLEITVSEDHLSAALADLAQRRGSIQEIQSRQDNKVVIAAVPLAEMMGYSTVLRSLTSGSATFTLELASYQALNSQEQSALLQRRMGLV
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MLKHSKVIPILVFDGGPLPGKLEEESRREISRKENLAKAVAHEESGNHSAAYECYQKAVDITPAHALRLIKVLQEEKIDYIVAPYEADAQLAYLVINGLVDAVITEDSDLLAHGCPKVLYKMDKFGNGMQILYADLVKTKELCFTNFTQQMVLEMCIFSGCDYLASLPGMGVKRAHALVKRFKTFRKAIKWLKFQGTDIPPGYEDAFHRAVLTFKHQRVFDPVSQRAVFLTEPYGSDVPDNLDFVGPPLSPETARAIAAGQICPISRTPFEDLKHFEKGTSASKRKRKADVLPERNTMHRYLSVNTSTSAKKPFKQPRTAVAAAPPSAAERPQQPEPEEQVPRTADDLDEWNRLPSASLPESDELDAPTPFQNQKPTANVERRQTANAFEFDLEREAPLASLDFDSDLELDNPFEAFRIKARKSPGRKGPADLFAAFGDDWSTDEALPATRAADSPRRTPLYTSGRLEPRADLQPRPQSGRESENGGLGFGERSGAGGRGFDRRAAALQPVRLPDLNRGAVDRPKVAKKTSSFFKKPAAAAVHLEEPAVVGGVTAGLGRTGDGGNGQGTGEMYAREESPLEDHGVEEENRDRPISRGFGVATTDYRLQGLHDDGQGDDDRQGQGCSKKLEHLEAYSSTATKAMEGLVAKLRTFKYVPSSSRQSALRNPLGNKMRNAFPR
The following text describes a protein:
Function:
Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSENPLLALRDKISALDEELLALLAKRRALAIEVGQAKLLSHRPVRDIDRERALLDRLIHLGKAHHLDAHYITRLFQLIIEDSVLTQQALLQQHLNNTHPHSARIAFLGPKGSYSHLAARQYAARHFEQFIESGCAKFTDIFHQVETGQADYAVVPIENTSSGAINDVYDLLQHTSLSIVGEMTVTIDHCVLVSGATDLNTIETVYSHPQPFQQCSKFLSRYPHWKIDYTESTSAAMEKVAQANSPRVAALGSEAGGMLHGLQVLERIAANQTQNITRFLVLARKAINVSDQVPAKTTLLIATGQQAGALVEALLVLRNHNLIMTKLESRPIHGNPWEEMFYLDIQANLESQVMQSALKELGEITRSMKVLGCYPSENVVPVEPA
The following text describes a protein:
Function:
Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z (By similarity). Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity). The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity). Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins (By similarity). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Following DNA damage, localizes to sites of DNA damage, such as double stand breaks (DSBs).
Domain:
The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.
Sequence:
MSPPGGDATVGSDEKRQKGKATPDTIKMGCIAMVMKEGQLRRAEILSIKDTKSGRQFYCNFDNFNKRLDEWVPAARIDFEQDVEWPNPDKDKQKDAKTKKNNSTVSKKQPSKKNNQKKASKREQSVASDGQTPHPWTEFVESQPGKNNRQRGKTEDGTDVNASLEVGGDKGVKRKADEIDMDEDEIPAAKKQRQPSFSREQEIEKLRTSGSMTQNPTEISRIRNISKVEFGRYVLFPWYFSPYPQIFDQEDCIYICEFCLSYYGELKSFVRHRQKCTLHHPPGNEIYRDDYVSFFEIDGRRQRTWCRNLCLLSKMFLDHKTLYYDVDPFLFYVMTTRDDRGCHIIGYFSKEKESTDGYNVACILTLPQYQRKGYGRLLIQFSYELSKIEGKLGSPEKPLSDLGLLSYRQYWSENIIDILLGYNERKEACTIENIAVALAMTTQDVEHTLQALKMQVYHKGEHKIVVPEKLIKQREKSKAKQKRLIDPERIQWKPPVFTALNRTWGW
The following text describes a protein:
Function:
May act as a RAB27A effector protein and play a role in cytotoxic granule exocytosis in lymphocytes.
Subcellular Localization:
Cell membrane. Note=In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery.
Domain:
The RabBD domain mediates interaction with RAB27A.
Sequence:
MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKVKDDQQLKNMSGQWFYEAKAKRHRDRIHGADIIRVSMRKKRPQVADEQSKDRANRAKESWVNNVHKDAFLPPELTGVVEEPEEDVAPASPSSSVVNPVSTMIDASQENTRKSAISPAKPRKNPFNSSMLPEDHLSQQTKNEQSKNGKTGLFQTSKEGELSESKEESSILDISSQKLEKPKQTLPGPESGFPIKAPVPKPRKMIYKSQDLKQDDNQPFPRQRTDSLTTRGAPRGILKRNSSSSSTDSETVRFHQNFEPKSKIVSLGLTIHERISEKEHSLEDDSPSNSLEPLKHVRFSAVKDELPQSSGLVHGREVGEFSVLESDRLKNGTEDAGLTDEVWNDPQPSQYTNGLPFQSSASSPSPSKNETSQPTTSGSFPINEHPSSKEFLTTRAQSTENSHTINEHKTSSSELSKNPADELSCTEPESSQVPDCSSRDHQQGSEEEPSPVLKILERSAARKMPSKSLEDISSDSSNQAKVDNLPEELVRSAEDDQKADQEPDTNECIPGISTVSSQPDNQFSHPDKLKRMSKSVPAFLQDESDDRETDTASEGSYQLSRHKKSPSSLTNLSSNSGMTSLSSVSGSVMSVYSGDFGNLEVKGSIQFAIDYVDSLKELHVFVAQCKDLAAADIKKQRSDPYVKTYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKINKQILKTQKLNLSVWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLKWYPLKRKTAPVPLEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPVFNHTMVYDGFRPEDLTEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVKSPNTWIEAILPLRMLLIAKISK
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLKLRTPTLNKVVELDNDATVEDLAAMVLSLGVVDFAIKGGFPPKPIDLSQGSKSLASAGIRNGDQLIVSTSGGEITKGNDIVSANRGHKDPVMGGFNKGSGTSSGSGGSGPSDLVTAPCGTRKLVLRVMEDDNSCMFRAVGYNMMKDADTMFELRMMVKDKIASDPETYSDAILGRPRAEYMSWITRQDSWGGAIELQILAENLGLTIISADVSTGRLDHFNPGKPTFCIVVYSGIHYDSVALAEVSDLYTNSSDVTVFSQDAQGAAVLESLKVLMAELKKKHYYTDTASFAVKCNDCGSTFTGEKGALEHAKKTGHTNFGEK
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (Probable). mL67/MHR1 also has extraribosomal functions, being involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells. mL67/MHR1 also acts as a transcription factor involved in regulation of RNA polymerase II-dependent transcription (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MNSVTTSTIGRLAFGVSRLSAVTNVAGAVRHASTHPTTAIPKPTTAVLKTSPLAEETAVELKSPSRLQLKSEPGNKGNPKGHGDRIWAFHHIEQGQVIYSTKPVISHQHLIRQQPFTGKNLVPRKIRKDYWRPLAMIELAGKDQGAVGRSVYQKLREFKKRHELDWANEAEEGRKLMHKSKRERGQELNDQKPNSVADMAAVLAGAGKGNLMWQVSRLGSSSELVGEIKKASGAVEKGAVVDVKRQLRRATVYWTNEQDKFHAREWSDNVSHEVGIPGEAEKKRMPIRMSSE
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins (Probable). Substrate specificity investigated with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide' where Xaa is the amino acid tested, was found to be Phe > Leu >> Ile > Lys = Ala > Trp > His >> Gln.
Sequence:
MSESVQSNSAVLVHFTLKLDDGTTAESTRNNGKPALFRLGDASLSEGLEQHLLGLKVGDKTTFSLEPDAAFGVPSPDLIQYFSRREFMDAGEPEIGAIMLFTAMDGSEMPGVIREINGDSITVDFNHPLAGQTVHFDIEVLEIDPALEA
The following text describes a protein:
Function:
Probable RNA demethylase that binds to both N6-methyladenosine-containing- (m(6)A) and C5-methylcytidine-containing- (m(5)C) RNAs, thus being a probable m(6)A and m(5)C eraser. Involved in responses to abscisic acid (ABA) via the modulation of the expression of ABA signaling-related genes (e.g. ABI3 and ABI4). Acts as a negative regulator during seed germination under abiotic stresses (e.g. salt, cold and ABA). Positive modulator of seedling growth and survival in response to drought and heat, but counteracts tolerance to salt.
Subcellular Localization:
Nucleus.
Sequence:
MELERFRVGLTPTVFYIPGFITDEEQTQLLNHIYGASGSKWKTLKNRRLQNWGGMVHEKGLVPQELPPWLTKITAEIHESSGLFPSAINHVLINEYHPDQGIMPHQDGPAYFPVVAILSLGSPVVMDFTPHLRLRSGDGYISKDQSPCAESCAPERDSFSVLLMPQSLLIFKDDAYSDFLHGISDSPTQCYNQVVNEAEALAYSNEEDSRKDGDKIFHRDQTRVSLTCRLVPKVRKNLFRF