lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Induces caspase activation and apoptosis. Allows the release of cytochrome c; Induces caspases and apoptosis. Counters the protective effect of BCL2.
Subcellular Localization:
Cytoplasm. Mitochondrion outer membrane.
Sequence:
MCARVPQVGIGSAPNSKDEVCTGMLVYSFLQCSRNCTFREELRSMGSDLQLLPDDFDDGELQTDGNRSGRCQTEADGPESGHEEEAIRLIAEQLAQIGDELDGNIQQGLVRDVARQFMNANLSEEDRRKYLAATMERVMQAVPQELEREKATLLFALLLAKQVVNHSPTLLRSVFRTTVDYINRSLLAYTRNLARNVSPGLEVLRMPSVAGKRPAPDRRRAEADGGLRPPSGFPAPATPDKVSPGETLRGF
The following text describes a protein:
Function:
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Sequence:
MALETVRRSSARIRKEEAINKFLKLLKEYPTVMIGDFSRIPANHFERVRRELSPDVKFFVMKKTLFKKACELSNREGLKKLSEMVPQSLVVIFSRKDPFDTYKLLSERKTEIFMKPGDVAEEDVVIPAGPTDLAPGPILMDLRAMNIPTKIQGGKVAIAESVTILKKGQKASAQIADLLRALNIKPLKVGFKVTGAIDESGLIYSPEVLSVTREDILRLLQEAHMRSLNLAIELGEINRHTLAPMMQRAAARAIALSMRLNWVSDLTIPLLLRKAVQLAKFLNEKIGG
The following text describes a protein:
Function:
Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in pro-inflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein; [Soluble secretory phospholipase A2 receptor]: Secreted.
Domain:
C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B; The endocytosis signal probably mediates endocytosis via clathrin-coated pits.
Sequence:
MPLLSLSLLLLLLQVPAGSAETAAWAVTPERLREWQDKGIFIIQSENLEKCIQASKSTLTLENCKPPNKYMLWKWVSNHRLFNIGGSGCLGLNVSSPEQPLSIYECDSTHVSLKWHCNKKTITGPLQYLVQVKQDNTLVASRKYLHKWVSYMSGGGGICDYLHKDLYTIKGNAHGTPCMFPFQYNQQWHHECTREGREDNLLWCATTSRYERDEKWGFCPDPTSTEVGCDAVWEKDLHSRICYQFNLLSSLSWSEAHSSCQMQGAALLSIADETEENFVRKHLGSEAVEVWMGLNQLDEDAGWQWSDRTPLNYLNWKPEINFEPFVEYHCGTFNAFMPKAWKSRDCESTLPYVCKKYLNPTDHGVVEKDAWKYYATHCEPGWNPHNRNCYKLQKEKKTWNEALQSCQSNNSVLTDITSLAEVEFLVTLLGDENASETWIGLSSHKIPVSFEWSNGSSVTFTNWHTLEPHIFPNRSQLCVSAEQSEGHWKVKNCEETLFYLCKKTGLVLSDTESGCQKGWERHGKFCYKIDTVLRSFDHASSGYYCPPALITITSRFEQAFITSLISSVVKTKDTYFWIALQDQNNTGEYTWKTAGQQLEPVKYTHWNTRQPRYSGGCVVMRGRSHPGRWEVRDCRHFKAMSLCKQPVENREKTKQEEGWPFHPCYLDWESEPGLASCFKVFHSEKVLMKRTWRQAEEFCEEFGAHLASFAHIEEENFVNELLHSKFNRTEERQFWIGFNKRNPLNAGSWEWSDGTPVVSSFLDNSYFGEDARNCAVYKANKTLLPSYCGSKREWICKIPRDVRPKVPPWYQYDAPWLFYQDAEYLFHISASEWSSFEFVCGWLRSDILTIHSAHEQEFIHSKIRALSKYGVNWWIGLREERASDEFRWRDGSPVIYQNWDKGKERSMGLNESQRCGFISSITGLWASEECSISMPSICKRKKVWVIEKKKDIPKQHGTCPKGWLYFDYKCLLLKIPEGPSDWKNWTSAQDFCVEEGGTLVAIENEVEQAFITMNLFGHTTNVWIGLQDDDYEKWLNGRPVSYSNWSPFDTKNIPNHNTTEVQKRIPLCGLLSNNPNFHFTGKWYFEDCREGYGFVCEKMQDASGHSINTSDMYPIPNTLEYGNRTYKIINANMTWYTALKTCLMHGAELASITDQYHQSFLTVILNRVGYAHWIGLFTEDNGLSFDWSDGTKSSFTFWKDDESSFLGDCVFADTSGRWSSTACESYLQGAICQVPTETRLSGRLELCSETSIPWIKFKSNCYSFSTVLESTSFEAAHEFCKKKGSNLLTIKDEAENSFLLEELLAFRSSVQMIWLNAQFDGDNETIKWFDGTPTDQSNWGIRKPEVYHFKPHLCVALRIPEGVWQLSSCQDKKGFICKMEADIHTVKKHPGKGPSHSVIPLTVALTLLVILAISTLSFCMYKHSHIIFGRLAQFRNPYYPSANFSTVHLEENILISDLEKNDQ
The following text describes a protein:
Function:
Component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations. Required for the adaptation to the presence of glucose in the growth medium; mediates in association with the substrate receptor VID24/GID4 the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNFRPEQQYILEKPGILLSFEQLRINFKHILRHLEHESHVINSTLTTLISQENASMDEKIEKIDSLLSRVSTVKKKMKHLHDCEALFIKQTKSRLLFMNRLQGIRDMESADFLDWSRVRLNRLVADYMMANGYHGAAALLCKDSQLENLVDLGIYKRYQLIHDSILQQELKEVLSWCSEHRAILKKNNSTLELEVRLQRFIELIKSKKLCQAIAFAKAHFGTWANEHPARLQLAAALLAFPEFTNGSPYSLLLSDDRWEYLASLFTSNFTAVHNIPSVPLLHALLAAGLSSLKTPLCYLDANDDNPLALQSQTVKQCPVCTPCLNDLGKALPYAHITQSAIVDSLTGEGLDSDNCPVAFPNGRVYGIQSLISWNEANGTREGFLRDPYSGKEFPFQLLRKVYVV
The following text describes a protein:
Function:
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
Subcellular Localization:
Cytoplasm. Note=May associate with membranes.
Sequence:
MKSAILITYDKEDVINEAKGLCDAAGFQVVHTIKQKFLKRPKYGISGGILERLEEISEKIRPDVIVFDEVLKPSQNYNLAAALHREILDREALILEIFESRASSAESKLQVKLAQLRYEMARAKEKVRLSSMGEQPGFMGIGKFEVDVYYNDIKHRMNTVRSKLEKAGKQRELHRQGRKRMGFKTISLAGYTSAGKTTLFNMMTGETRDQSSELFTTLSTTTRRVSINQEPFLISDTVGFISKLPAYMIDAFKSTLEELGHTDIIIVVIDIGDSIFELKKKFSSCMRTLSELGVEKDRMVYALNKSDLLEHSEIEEKIETLNLVDNKKWIPVSAKTGKNVKQLKELIGDILESHNSHKFGKKIGVEETFGN
The following text describes a protein:
Function:
Molecular chaperone. Has ATPase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTEPLTETGRQSHTFKAEVQQVLYILAHSLYTDREIFLRELISNASDAINRVQFEMLTNREVRDPDLEPQITIEVNKEARTLSISDTGIGMTADEMVEHLGTIAQSAARAFVKQAGEGAKQTASEIIGQFGVGFYSVFMVADKVTVVSQSYRPDAPAAMWESSGGDSFTVGPATRERRGTTITLHLKEDATEFADPWRIEQIVRRHSNYVAFPIMLDGRQINARTAIWRKAPRDVTNDEYNGYYRQLTLDSQPPLSFIHISTDAPVDLHAILYIPSRRERGILERRIEGQIKLYSRKVLILEEAKDLLPAYFRFVEGVVDSEDLPLNVSRESVQSGTAGGSPVMQRLRKTLTGRLHKELNELAERDPEKYRTFWKEFGPFIKEGIATDYEHRNDLLKLLRVQTTKSGEEWITLATYKERMIPGQKEIYYLMAASRDAALSSPHLDPLRARDIEVILFTDLMDGFMLSGLREYDGLRLRNIDEGDLDLPGEVERPAPAINDEQFTALAERIAAILGDRLKEVRTSRVLRDSPARLVADEAAFGREMQRIQQVLGQEVQMGPRILELNPAHPLIAALAQRAASNPNDPLLKLAAEQLYDNALLIEGLHRDPAAMAPRILQLLELAAGVNTPQA
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRFYRQGSSSESSSESSSDSDVQVKKPTRYVSSSEDEIEEKRIVLSAKDKIWQQFDESLKKVRNALKTNDWVSTTSEFDNMTKLITNGKTTRIIEKEGFPPSFIKALFIIQTSHRDLTTEQKKKLHANNNKSYNSIKQKLKKTCDLYAKELKPYHDNPALVNEQENKANSDDDDDDLSESESEESESSDDDKGKGKGKAAFGKKPATKAVVAKKPLTKKGDDDSESESEESESESEELISESWSSDSDDDSDSDSDDDSGDNKWMIKDDKKVVAKASVTTVRKTDKDKLDRRNAVVSPLSGSGSAVPTAGEGEGEKLTQDQIMKKVKEVISNRGKLKTDPMKQIQQLEYFYSLIQGDKETFIVLYELIAAQFDTASVKVALSIPVWQKVADGIKKLLEILETNTNFVLVLEHQEPTISKGQVAVTGNLLALFEMLDDEFSKSLQSINYPTKEYLDRLQDEQIILDLGESLQKYYESAGNNGAAAKIAIRRIEHIYYKSSNLKNNIIPSTMPLSEQITLMSKLSSFVYKFGDERLNARTILCNIYFNAINNKFHEARDMMLMSHLQDNPTLMDVSTQILFNRAMVQLGLCAFRCGYIQEAQNCVVEFSGLRKDLLAQGLSVQSKTAEKDTVREVEETTRILPAHMWIPIDLIETVNLISGMLIAVPQNAYRPFDNKFKTCKFYQRHMDSVDRQIFIAPSETSKDIIYQASKALSAGDWQQCLEHVNTLRFWSLIPDIDSVREKLTRIVQEVSLKTFLFTYSTSYDSILLSELADRFHLPKSQVHSIVAKMMNNHEISASMEHSTESITFRAEQTKLQYLALHYSESLVDFVEQNERIYDVKFGTSYRKKGDNDHLPIAGGQHHGHQHHGHQHHGHHHHNQQQQQHHQQQQQTTQHHHHHHQNQNQGNQQYQNKKHHNSNQQKSHKKRQNNSLVVNN
The following text describes a protein:
Function:
Protein chaperone involved in seed maturation and dormancy maintenance after high temperature fluctuation (e.g. secondary dormancy after 3 days at 40 degrees Celsius), probably by protecting heat labile proteins required for secondary dormancy (e.g. G6PDH, HOP3, SR45, ECP63, SCL33, RPL32B, ChlADR1, MSBP1, MBF1B, At3g01690, At1g15280, At1g15290, At2g31410, At1g11630, At1g65090, EMB2279, EMB1674 and RPL35C).
Miscellaneous:
MISCELLANEOUS: Boiling-stable protein.
Sequence:
MAKNKDDIKYATAQAKLSEDEAIRVSYKHGTPLEGGKIAESEPVELFSSAQRIEKGKEQSAASGDQTQIQRDIKDIKGTRTDDSPR
The following text describes a protein:
Function:
Vacuolar-sorting receptor (VSR) involved in clathrin-coated vesicles sorting from Golgi apparatus to vacuoles.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Single-pass type I membrane protein. Prevacuolar compartment membrane; Single-pass type I membrane protein.
Domain:
The tyrosine-based internalization signal may be involved in trafficking at the TGN.
Sequence:
MKQLLCYLPWLLLLSLVVSPFNEARFVVEKNSLSVTSPESIKGTHDSAIGNFGIPQYGGSMAGTVVYPKENQKSCKEFSDFSISFKSQPGALPTFLLVDRGDCFFALKVWNAQKAGASAVLVADNVDEPLITMDTPEEDVSSAKYIENITIPSALVTKGFGEKLKKAISGGDMVNLNLDWREAVPHPDDRVEYELWTNSNDECGVKCDMLMEFVKDFKGAAQILEKGGFTQFRPHYITWYCPHAFTLSRQCKSQCINKGRYCAPDPEQDFSSGYDGKDVVVENLRQLCVYKVANETGKPWVWWDYVTDFQIRCPMKEKKYNKDCAESVIKSLGIDSRKIDKCMGDPDADLDNPVLKEEQDAQVGKGTRGDVTILPTLVVNNRQYRGKLEKSAVLKALCSGFEESTEPAICLSTDMETNECLDNNGGCWQDKSANITACKDTFRGKVCVCPIVDGVRFKGDGYSHCEPSGPGRCTINNGGCWHEERDGHAFSACVDKDSVKCECPPGFKGDGVKKCEDINECKEKKACQCPECSCKNTWGSYECSCSGDLLYMRDHDTCISKTGSQVKSAWAAVWLIMLSLGLAAAGAYLVYKYRLRQYMDSEIRAIMAQYMPLDSQPEVPNHTNDERA
The following text describes a protein:
Function:
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
Sequence:
MNCQLLKDHKERVWQVAWHPNGQILASCSSDKTIKLWQLMNDQYKLIQTLDECHTKSVRSVSFSKDGQFLASGGFDTVVGVWMYDGSKYKLIQQLEGHESEVKGVAWSADSNYLASCGRDKTVWIWDHEDLEFSCNCVLQAHDEDVKCIKWKDTTLYSGSYDNSVIRYTYGEDDEWDHKQFQIEHQSTIWSIDIFNKLLLTTSADCTAKVFSIQDGTLKPIQTLQGFHKEPIYSGSFSYDGLYFALGSADNKISVFKKDAIDELGYPHYALDQIFKDAFEFDVNCVAFNPKNYLLATCSDDENIKVFNLQL
The following text describes a protein:
Function:
Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. In association with the zinc finger protein ztf-11, negatively regulates the expression of non-neuronal genes during neurogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MSRPLGFIGYEFGDDEMFVQQMIEKKSNAEQAKMLEQQKKMLECTETMPEESEPVPMKCLDFEEAFQSESVSKGYESPYKNISFLKEDAVTVNTMSHCPADDIAKLIRNIQNSVYTLGIEEARQCRRGKLLNVLKPTGSASPRYLQPTPPKNVAEETTGSQ
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase involved in the regulation of grain size. May limit grain width and weight by restricting cell proliferation of the spikelet hull. Possesses E3 ubiquitin-protein ligase activity in vitro.
Miscellaneous:
MISCELLANEOUS: Plants silencing GW2 produce grains with increased width, resulting in enhanced grain weight, whereas overexpression of GW2 decreases grain size and weight. The naturally occurring WY3 allele of GW2, which encodes a truncated version of the protein with a 310-amino acid deletion, increases the number of cells of the spikelet hull, resulting in a wider spikelet hull, and subsequently accelerates the grain milk filling rate, resulting in increased grain width, weight and yield.
Subcellular Localization:
Cytoplasm.
Sequence:
MGNRIGGRRKAGVEERYTRPQGLYEHRDIDQKKLRKLILEAKLAPCYMGADDAAAAADLEECPICFLYYPSLNRSKCCSKGICTECFLQMKPTHTAQPTQCPFCKTPSYAVEYRGVKTKEERSIEQFEEQKVIEAQMRMRQQALQDEEDKMKRKQNRCSSSRTITPTKEVEYRDICSTSFSVPSYRCAEQETECCSSEPSCSAQTSMRPFHSRHNRDDNIDMNIEDMMVMEAIWRSIQEQGSIGNPVCGNFMPVTEPSPRERQPFVPAASLEIPHGGGFSCAVAAMAEHQPPSMDFSYMAGSSAFPVFDMFRRPCNIAGGSMCNLESSPESWSGIAPSCSREVVREEGECSADHWSEGAEAGTSYAGSDIVADAGTMPQLPFAENFAMAPSHFRPESIEEQMMFSMALSLADGHGRTHSQGLAWL
The following text describes a protein:
Function:
Binds specifically to H3K4me3 regions of target genes (e.g. WUS and WOX5) promoters to repress their transcription via chromatin remodeling. Required for the shoot apical meristem (SAM) organization and maintenance, by confining WUS expression to the organizing center, and for the quiescent center (QC) development in the root apical meristem (RAM), by repressing WOX5 expression in the root proximal meristem. Plays a role in DNA repair and in cell-cycle control. Required for the repair of DNA double-strand breaks (DSBs), both natural and induced by genotoxic stress, by homologous recombination (HR).
Subcellular Localization:
Nucleus.
Sequence:
MAEFTNMLMNPWVLHLQKLELELKCPLCLKLLNRPVLLPCDHVFCDSCVHKSSQVESGCPVCKSKHPKKARRDLRFMESVISIYKSLNAAVSVHLPQLQIPNDCNYKNDALNNSNSPKHGESEDSEMTDKDVSKRSGGTDSSSRDGSPLPTSEESDPRPKHQDWTEKQLSDHLLLYEFESEYDAANHTPESYTEQAAKNVRDITASEQPSNAARKRICGDSFIQESSPNPKTQDPTLLRLMESLRSDDPTDYVKAQNHQQLPKSHTEQDSKRKRDITASDAMENHLKVPKRENNLMQKSADIDCNGKCSANSDDQLSEKISKALEQTSSNITICGFCQSARVSEATGEMLHYSRGRPVDGDDIFRSNVIHVHSACIEWAPQVYYEGDTVKNLKAELARGMKIKCTKCSLKGAALGCFVKSCRRSYHVPCAREISRCRWDYEDFLLLCPAHSSVKFPNEKSGHRVSRAEPLPKINPAELCSLEQTPAFTKELVLCGSALSKSDKKLMESLAVRFNATISRYWNPSVTHVIASTDEKGACTRTLKVLMGILNGKWIINAAWMKASLKASQPVDEEPFEIQIDTQGCQDGPKTARLRAETNKPKLFEGLKFYFFGDFYKGYKEDLQNLVKVAGGTILNTEDELGAESSNNVNDQRSSSIVVYNIDPPHGCALGEEVTIIWQRANDAEALASQTGSRLVGHTWVLESIAGYKLHPVIG
The following text describes a protein:
Function:
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity (By similarity).
Subcellular Localization:
Preautophagosomal structure. Cytoplasm. Note=Diffusely localized in the cytoplasm under nutrient-rich conditions. Localizes to autophagic structures during starvation-induced autophagy.
Domain:
The L/FRRG motif is required for recruitment to PtdIns3P.
Sequence:
MTQQPLRGVTSLHFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSVGLVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKDKLVLEFTFTKPVLAVRMRHDKIVIVLRNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MIIVKHTCPRLLLRQVRLWHVSVWSMENVDYRIVAQRRMTKSNYHCTIVSHKILNNMMALFYFYIKKCFKVKSEARGDQKELKVCQGANFRWNCKELTRSGAFVSLPDEEGILPVSEESEGFGGILGSSSLQVGQEVNVWVLHIARGQVTLMMEKEEDIEGLNMKLNKGVVHIATNPFELAFRKNEEITAFVSRGEIFEIVKEREIEMQKEDLLTKPANIRSKIDLVKQRIATLGEHIKVKRFVGYNLGKGLEKESQDFAAEVAAQTVAKPSPAVPMDQPTETKEAVEKPETIAVSAVLVMQLREETGAGIMDCKKAIAESGGDIEKAQEYLGKKGLSSADKKSSRLTA
The following text describes a protein:
Function:
May be involved in cell wall biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MSEMAHLLTADSQSTRQCKQLSVWTLVTFFLVNHLSAIFTKPTDGLELTAFEKGLRALVQGQLKPCLTIEVEGLRAGCSLMAALEAETAAVKDLAARRKSDNSRFSISPDACAYRLQGGPSLHKFAATMHPYLKHVLKRYATFHRHCTEYDNLRDVYDSKKNPQCRYVMWSCTFGLGNKLMSLLSTLLYAIISQRVLLIESPGWESLFCEPFPGSKLQVPEGFSLVEMYTSLSFADFRKLNCGESTTKEPRCIRSVVVVVFTGESKRQDHSFLVCPTAMAAVREIPFLHFRNSNQHFAMGFFLNPALRPLLELLFPEHNVFHMLAQFFLSPSDAVWVQIKSFYERNLQPASRNVGVQLRESKGEYRQHYDDVVPLCILNKAALCPIELEAQLEREKRVAQSPSSSESNISRPLVSVYISSLVGGHYKSLKQSVPKLEPKMLQRFVVVAQVISTDSHFKTSFTDGEQRDDIRHAQKALVDMWLLSLSDILLTSHMSTFGYSAQGLAGITPYHLKPWLNNACWQSISSDPCFHFAPHQVHCPNDNFTLRDPLKETPYIKKCPDLPETGLQLAE
The following text describes a protein:
Function:
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MIEASKLKAGMTFETADGKLIRVLEASHHKPGKGNTIMRMKLRDVRTGSTFDTSYRPEEKFEQAIIETVPAQYLYKMDDTAYFMNTETYDQYEIPVVNVENELLYILENSDVKIQFYGTEVIGVTVPTTVELTVAETQPSIKGATVTGSGKPATMETGLVVNVPDFIEAGQKLVINTAEGTYVSRA
The following text describes a protein:
Function:
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
Sequence:
MATISLQIGQAGNQVGYAVLERLAHEFDCPDSHFRPVQNARASAIRSGQHRARAVVMDSEPKVVRMLNESTLRLPWCYSKRQTMCEQRGAGNNWANGYMRYGHEYHEFSLDAIRREAEAADRVDAFQVYSSVAGGTGSGLGARVTELVREAYPKSALTNMIVLPYMTGEVIVQFYNAVLSLSHLTTASDAIFLLRNDDAHRVAQSSYKLKTVTMDALNNVYANDLAHALGPSRAAAGADCGLLDPSLLSQAQRVAHLVPHPDYKLLTTHSIPQMPESYQAFSRYDWSSLTTTARAMALADSPVEEGFNRRLKPAPGPVPGDLNQQVAPARGATSLATLVTLRGDQLGTANCSAFWEEGLYSAWAPSPVLVAGSTLAFGGHAKSVSTVLNGSRNAMFLDAALERTQRMFSKRAYVHQYEAFGLQATDIENAMLICEQVVASYAGL
The following text describes a protein:
Function:
Monofunctional pyrimidine deaminase involved in the riboflavin biosynthesis pathway. Also has a reductase domain that lacks catalytically essential substrate-binding residues.
Sequence:
MYCFPLSPNSTHNLYPSNCSSPPHFLSPRPLKNQAKDLIFASRKNNVFCSSAKRVSISLINSGNEPKDSIFTSRLKTKRVSVSRISLGDELKDSSFTSGLNYGFCSAAKSVSFSGISLGNGERVVNVRCTGESIEENGNEFYIRRCVEIARKAVGHTSPNPMVGCVIVKDGKIVGEGFHPKAGQPHAEVFALRDAGDLAANATAFVSLEPCNHYGRTPPCTEALIKAKVKKVVVGMVDPNPIVASTGVSRLRDAGIEVITGVEEELCRKLNEAYIHQMLTGKPFVTLRYSLSVDGDLSDQLGAEVMESGGYYSQLLQEYDAVVVSSFSLSTKYFLSSKEPGAKQPLQIVLAKSSGSLQLPTVSNDTSSRTIIFSNKEITLELEASQKGIETVVLDRMNLAAILEHCKRQGLCSVMLDLRGTTADFAEILQEGFEQNLFQKIIVEVLPILGASNKDPLKYMQQNRRLRNLTSRTLGESILLEGYF
The following text describes a protein:
Function:
GTPase, binds and hydrolyzes GTP. Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT). Plays a dual role as both a protectase and a reactivase for MMUT. Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP.
Sequence:
MNVSMLLLFPHHNFLRSFSKTFFRNYQFIFHSGTRFGSGFICTRPLNYIGLYHAKWMLLLSSFKRKLGVQTTIKLHTEGFSDKERRYVDKLYTGLIQGKRASLAEAITLIESTHSRKRDLAQVLLQMVLTYHREQEQSNKGKPLAFRVGLSGPPGAGKSTFIDYFGKMLTENGHKVSVLAVDPSSSTSGGSLLGDKTRMIELSKDMNAYIRPSPTRGTLGGVTRTTNEAILLCEGGGYDVILIETVGVGQSEFAVADMVDMFVLLLPPAGGDELQGIKRGIIEMADLVAITKADGDLIVPARRIQTEYTSAMKLLRKRSKVWRPKVVRISARTGEGITEMWDKMKEFQDLMLASSEFISKRQKQQKVWMWNLIQENVLEHFQNCSSVKDQIPLLEEKVAAGDISPGLAADLLLKAFKAQN
The following text describes a protein:
Function:
Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MPFRGDNFKDFKEINKIRKENNKYKYIAVFITVIPGIILGGFMGKKLAQFLEVFDLYAPDVSEDD
The following text describes a protein:
Function:
Acts as a topological specificity factor during plastid division and specify plastid constriction sites (such as the Z-ring) in a MCD1-dependent manner. Especially involved in epidermal plastids division in a FTSZ1-dependent manner. Required for the proper formation of FtsZ rings at the division site in nongreen plastids (e.g. etioplasts). May contribute to gravitropism in stems and hypocotyls. Stimulates MIND1 ATPase activity. In cooperation with MIND1, prevents FtsZ ring formation anywhere outside of the mid-plastids.
Subcellular Localization:
Plastid, chloroplast. Note=Dynamic protein that is restricted to a single spot at one end of chloroplasts or as two spots in close proximity normally towards one end of the chloroplast. Seems attached to membranes.
Sequence:
MAMSSGTLRISATLVSPYHHHHRNRLSLPSSSSKVDFTGFISNGVNSLETQKCTPGLAISRENTRGQVKVLARNTGDYELSPSPAEQEIESFLYNAINMGFFDRLNLAWKIIFPSHASRRSSNARIAKQRLKMILFSDRCDVSDEAKRKIVNNIIHALSDFVEIESEEKVQLNVSTDGDLGTIYSVTVPVRRVKPEYQDVDEAGTITNVEYKDTRDGSVDVRFDFYVPE
The following text describes a protein:
Function:
Acts as a modulator of condensin function, possibly by binding to the condensin SMC subunits and thereby inhibiting their function. Negatively regulates the condensin I complex in mitotic chromosome segregation. Negatively regulates the condensin I-like dosage compensation complex, which functions in the regulation of X chromosome-linked gene transcription, by limiting the association of the complex with the X chromosomes.
Subcellular Localization:
Nucleus.
Sequence:
MTYPQQRLLTVDILNFKCYQHHKSFGPFDHVTTFIGMNGCGKSIMIEAIAFVFGEDLPDPKNPHNEHLFYDYNIRCVVSLKFEMPDGSTKRFTRIGLKTTYTYMIFNKYVTEEEYLLELGKMNFRFAGQNISVYNKTTLKVTRKSAEELGAFFDIVSNSIEFKPEYDELKAKLNFAESTVLRWAKMIDSIELEKEKFITLTLYKLYLCDKEIQETKEKFVAEQLKVNAKNAKMPLRISRYSEAIPKQTPSPNFKNNAIVVRPKTHNHYDNLITVDKLNSYLNEKVTERRELLQFAVNHPNMNIRFSEEGPNIYAREIDYTELPEYYKKESDDIIATSYKRSMLEKEIKKIRQCWLDENNIKDDANIDNINMRIKEATTKHTLALNIESEARLNWEKLRVMRSARFNNFMAPLQTSLSRIYAEIAQDEDSLAFLRPLDEEEPYLAIDAFVKERHSEHISTRTFHGGSRMIVDLALIFAIHEWKPSPLVVIDDIDRNLYHEASKKIEPYLSRQKQTQFIVTTKEDSYFTEVTKTITLEN
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 1200 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MTIKRNLVKTLQSIRYQATTATAHAESTLNPLPNAAIPPKYALVTVRSFPSLEPLTFVPVPTSTVAAPLRRDILWRAVVYENDNRRVGASNPPGRSENGFSRRKLMPQKGSGRARVGDANSPTRHNGGRALARTAPNDYTTELPSKVYSMAFNNALSHQYKSGKLFVIGGEKVDLISPTPELDLNRLDLVNTNTVEGKEIFEGEVIFRKFLEEFQLKGKRLLFITDKTREGLIKSSDPYKQKVDVIQKELVEVNDILRAQAVFIELEALEYLAMAHQKEILHSVSN
The following text describes a protein:
Function:
Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.
Subcellular Localization:
Nucleus.
Sequence:
MPSIVTSHAPPPPMPGFQVPNDDASYLKGVVADILQRDNMRFPGAQPVSFAREHVAELKRQEYFMCEKTDGLRCLLFIHWQQDHNGNPQPATYLIDRKNNYYQLQPPLRIPYYKDPTNPEPFLYGTILDGELVHDQYPNEATPRLNFYIFDALAVDSENLTGKTLDKRLGRFQEWVLKPYHKKLTSTPNPDLRPFALKEKKTYPAYSIRQMFDNVLPTLKHGNDGLIFTCKSTRYEFGTDRHILKWKPPHENTIDFKLRIGEFPLMDPMDGEEGLIPDYDAMPTSFELLVLHNNSNYERFANLAITPAEWEILKSLEQQLDGRIIECYRNLDGQWKFKADGDGTPRWRDDKKDANHISTVKSVLESIESPVTEDMLLQNEEGIKKAVYTIQGRADKYQPPSQQDGERDAKKRKFNETTSNGGAH
The following text describes a protein:
Function:
Methionyl-tRNA formyltransferase that formylates methionyl-tRNA in mitochondria and is crucial for translation initiation.
Subcellular Localization:
Mitochondrion.
Sequence:
MKLSPSLFSRLNPGKPPWRVLFFGTDKFAVHPLQNLLERMQDGSLIENVELVCPPERRRAINKKVQNENFITAREYAIEEGIPIHEWKGKEGWAPEYSPEGPYDIGVVASFGYLIPNNVIDLCPSGMVNIHPSILPKWRGAAPMTHAILSGASHTGVSIVGVSRDRFDHGKILLQENYKIRDDIMYDDLSDELAILGSRMMLYTIEHWDELWKTAKVQPKEGASKAPRNSIQTGFISWEDHTWEQIWGKWRALSTRVGIHTSWGGKKVRLIKMSPEKIEDDVEEIREALPGQTKYDKEREILFIKCKDDWAGFTELQFECKDIIKARDFANSYLLQSIKNSKDGRTFKDLEAASC