lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Could act as a receptor for an unknown ligand.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTSLLSKLSLPLLQLLFLLLSFSTTGRAEDNTTINVLSLMYSPDVQEVEVDSLNAGFDASLTARGWKTNSKARVSFIRPPSYDTPVAEFFESVVKESEGKLMIVFGPFGGPNTMWVKGELSKHGAVSFGPLAFSTEVREWDPHLYFISVEPNAELLALFRYAVVFLGLPRVGITYLKGTPSGEALYEFALEISSMMGHELCGAFAAAGGVGADEDALAAEWNQFVETRPQAVLLFAPVRNPATEWFIGRIVKDERTRQMYVLAPSTSQGPLIRTWRDALYASNVSLNDGQLIITGTIPPSNLLTLASVRRFREEMDNHLKSNSEWGGFSKPPHFSTDEAISDLMMTGWLTGEILSQALHSTDVLTDRTAFMDSLYRQRRYVVDDLVVGDYGNECGEFASMQGAMCNCNQGGSAVYMKEVVDGFRIEPLQRGFLAWGASQCSSRDVKISIPLSGFVMHLSDYFFSYRSAKRWYEGVSSAPVIRDDFGEDILHFDVLPLSTQMGVIALEALLNMREIVIIYGAVDEDILELPGPVFVDPLLLYPRINRFNRNVLLLSPTVRQQLYVLAMHLSNASTGAVSAAIRSKRAEVIGDVLNKSLMTFDVALKSMLLLKESDTLVDHLPSSGDVVAIGLTPPDAHAIAQYLQSRNDRRVYVLFSEVAQLYDEFVEAFNATPAAVVSASRLVFATNLPHWADKNTESDTVAMFHAYNPRESTWTPLRLRGFATARLLRSIVPRMKRISPSLLVDFFYTESNIRVDDMHYGPYSDVECVKGRVTAANRCETNFGAGNISVWSMSRVLDPRVPVLSRGVTPSLEYAVMDESSLSPSQLAGIIVGSVFFVALAIALCVLLCLFVRVRGQRDTVPKSSSDLVTFINDSEVCVPMFEMLRGGECGVVTIVCTDIESSTAQWSTHPELMPDAVLAHHTMIRSLIMQYGCYEVKTVGDSFMIACRSTSTAVELASDIQRSFLQHCWGTTVFDDFYRNSEMQKAEDDDHYIPPSARLDPEVYRQLWNGLRVRIGIHTGLCDIRHDEVTKGYDYYGRTPNMAARTESVTNGGQVLLTYAAYMSLSTEERDQLDATSLGPVALRGVPEPIVMYQLNAVPGRAFTGLRLDRGFYFDEDVENFSFSSNSLSFDSLKLSGSAQTISDALHSLLSTFKPPQRERLLALYCERWNVPLPMGGSYAWDDAYCEEVIRRIAVKVGPFVGRYAS
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTMQSDCSYIKSLYVTCNILGFLPPHNLGTNPLPVSLRFKIYTLCHIFLSIFVFFYSSFGRETYLYDSYDPTVGITDKIANVTLSLLSVVLRVFFVFWNGKSLKEFLNRAYEISKKEEFKCFSPRYFNLQFIGFNCYMVLIIGFDGWVWNSTVGFRIFRYYVGRSVMYYASNTVVFFVSHSALIIKRLFVSLNLLLEDELGKILGCKKPELRKIRIYYNQICGLCDNFNKIFGFVILSVIIFTISYILNLTDLLLVYAVRKKEIKGFTYGNDLIVLSILWMLTLLIFSFFLAHSCAKAVSETDQITTICFNYLNKISTVPKNYEEFVLKEEINLLLRQVTIRRPKFSAAGFFPVDFTLLGFILASVTSYIIVSIQFIQ
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
Sequence:
MADFGISAGQFVAVVWDKSSPVEALKGLVDKLQALTGNEGRVSVENIKQLLQSAHKESSFDIILSGLVPGSTTLHSAEILAEIARILRPGGCLFLKEPVETALQREPLTPEEVQSVREHLGHESDNLLFVQITGKKPNFEVGSSRQLKLSITKKSSPSVKPAVDPAAAKLWTLSANDMEDDSMHLWPCRRTGKREVKGTDELPTQVSLWKLLPGRCLPLCQLPLPWDASLQTWGKGASE
The following text describes a protein:
Function:
Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGCLRPWARYGLLVVAHLLTLGLGAVLFQALEGPPACRLRAELRAELAAFQAEHRACLPPGALEELVGTALATQAHGVSSLGNSSEARNWDLPSALLFTASILTTTGYGHMAPLSPGRKAFCMVYAALGLPASLALVATLRHCLLPALSRPGAWVVHWQLSPARAALLQAVALGLLVAGSFVLLPALVLWGLQGDCSLLGAIYFCFSSLSTIGLGDLLPGHGRSLHPVIYHLGQLALLGYLLLGLLAMLLAVETFSELPQVRAMGKFFRPSSPVTAENQGGILGQDELALSTLPPAAPTSGQAPAC
The following text describes a protein:
Function:
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Subcellular Localization:
Cytoplasm.
Sequence:
MAWPRRAAEVARSTMASRLDKLPEAVSRLQSLSHRQLLRLAQGVCIPALSPSLHKGQSGRVCVVGGSLEYTGAPYFSAHAAALMGSDLVHVLCEWNAATPIKAYSPDLMVHPHLRDSSSLARGLEPATEAVRALVDRVHVLVLGPGLGRDPAMLRSVAGILEYVADKHEGGIPVVLDADALLLLSEQATAAAARAALRRFPPDRVILTPNAVEAKRLAGAFELDDPARLAEHLNCTVVLKGGPDRIYAPGGSSPLSCSHEGSLKRVGGQGDTLTGCLAAMLAYNRAIHDFGIAEPDYTGLEGGTLSASERTALCCYVACAVARGASHRAYEAQGRAMQTSDLNGHVGAIFRDFFPERQ
The following text describes a protein:
Function:
Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway.
Subcellular Localization:
Secreted.
Sequence:
MYYLCIFLWVTSVACQTSKEIYQLLSKSHTNQNLVVSPVSIETILSMVFMGAEGSTAKELQSALGLPSEDKEAVAARYGALLNDLQGQEEGPILKLANRIYVNDQYSLNQNYNLAVREPFKSEAESISLTNGPVAAERINQWVLDQTSGKIKGMIDPGSMTSDVKALLVNAIYFKGQWESKFDPAKTRASTFQVTANKSVPVQMMAQMGTFRANYFRDLDAQVIELPYLNSNLSMTIFLPREVEGLSALEEKIVGFARPLVAKEVYLKLPKFKIEFRDELKETLEKLGIRELFTDKSDLSGLFADKSGGKVSQVSHKAFLEVNEEGAEAAGATSVAVTNRAGFSTFLMADHPFAFVIRDANTIYFQGRVVSP
The following text describes a protein:
Function:
Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MAAENVLQTTGLNEVYSNSFGVFLLSFDLVQGNVIELDERFIDAKDQGKWLVEFYAPWCGHCQKLKPVWADVGIQMMKNHPKLHVARLDGTRFGKVMDMFDVKGFPTIKYIEGDKVFTHTGGRTSKDIIDLQTKHKGELPAVKQLSSSNSLQQYRQSKAVFFVIAAEDTTSELATLFSTVADKRILDAFYYHVKPNVIPEDMRPKNVPAVLVFKDGLHYQYEAPEGSLSEEHLSDWIGAEMFPAFLRIGNDNINPIGRTEKLIAVGLVFPSATTYKSHPHNQMLELIKKVAIDHRETYYKKVQFGYMEDSNMLSDIILRSVEVPGIFIIDPVTYLYYEVDEPLEQTEESLVDFLNGIIDGTVKAKGGNSFFRKIYRVFYEIIKSVVMMWLANPILMTLLLALPTVLITFICYSICTAEPIDEDAEYPDSDEEEDDEGDRDGPKIEEIEDEDPSGHKKTE
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MGAAAGKAVEDQASAGGATTRAEDRMAVAERVILELERRRSSGDGSDVGIWDAQATCTNSGLLAAVDEIVFLKEMHAFPTASAAGRRMDGALRAAMSCLMEEFLSLRVWDGSQLEGRSGLRFAVDKLSVSVAAARGASSSFAFLTGGSTASTVRTSTAELSSGTVDELYASGSGSQPAGPDVFSDGEFPDELDLICPASLSILHEISLRVIRAGYTKELLHTFANAPCEVLDRFLSILQIQVGCSPEIETDESISYENAEWWTAEDMIRRWILATKLVGKALVAMQTQLLAQSNGAFDRFKNDYLMAMAKRRSYILLRFADGFTSTRSPEKLMYVLEMYEVLGSAVPGLVLVLTGQHKELFSRQVEVVLAKLARALRVMIGGAVTKVRAGVGSGTQSETRGVGGGVHPLTRYAVSCIESLAPHRGALDVILASTGGILEGVNSFGDLFSELVASLEPKLEEISALRGEEGGGLRHLFVANNTSFVLKRAGVLGGDDEWTACHRSRVEQHITSYIEASWAPVVACLEAGKPATKALAKFNAALEKAYNGHVRCEVSDPELRAALRKAVSEKVVAAYGAWLIEHPKLGKSARYTPDSLAGLVSELFEGEDAAAR
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MSAIRKIIQRQLFQKDDERIQAIVNVSKLDGKKKKNQTLLCLAVTIEHPIAVRLYFVKGEKDDTFKKKDRFNLREVREIDGINPKKASPEFHITIGDHQYVILAGSAEEKDEFIRELYKLSCQYLPVQMPDFCNFSLPQLESETSIIPIELPEHDMAMQSDYQPISNKEDADFRKLIARANLTIGEAHIFAEMLTEQLQSLDGANINSMMDSENSVNQLLSSIDAALTGVESVEKELDRCDDILAFVRNSIELIEEKDSLSVVERKNKQRLNEEIVSFVNSLQAVTDSHIETLKQANFSNPESVQRCTDAARAVAQFWHGRISKPMLQMKAYQDRNDELTAVDVFVDRLMSHLSALFSNLNDLSLDHEWHELCIPKQSQRFRALSPLSDLINWLKTNRPKACNLVLQKYIDSTNLLYKRLFDNFFETLINKVPKANSSEKKSKANESANISLRSDNQSFLSTSSEIDTEVLPQLIETVLAELSAVIDAEQKFVVRFFHINSELLAQFDTTSTGSGDSSSLGGRSMEKHMNEQVRHVMGNLFDSLNIHLDSFCRAVCRHNPSNVLLLFVIMSKKVLLPQDPSSYFSITFGSLVVLIKRQFDAFIQMECSQYSEVRIAKKTRIGILPSIFRFANFVRRAEIIFENAERRTDLEKAYFNLCRAVCDGIQKAAANQYSKSPSSVVKFENYHELYLTLSELKISCLDQQRKDAKALKEEHIDAYVKEFMGRPLKEIQTFFDNVNNFIETRGIRPDEISYQQQFSRIELKKVISQHPGKEVKKGLEQLYKKIEKNLVANSSLLQVVWRDMQEQFVKQIAEYNKLILTCYPGSKIELEVSTDTVLQFFSEIAQQH
The following text describes a protein:
Function:
Catalyzes the reversible phosphorylation of UMP to UDP.
Subcellular Localization:
Cytoplasm.
Sequence:
MHKSNNKIRQRIIIKLSGAGLTKENSQPFSNDFFETIINQLKVLKESYQVGIVIGGGNIIRGNNCQEFNIAEYHGHQLGIIATVVNGYFLKAKLDAHNLKSALLSAISCPSLAVQILSQQTIDKAFEENDFVIFSGGTGNPYFSTDTALALRAVQTKAVAILIGKNGVDGVYTADPKKDKNATFLPTLNYDHAIKNDLKIMDITAFTMCKENNLKIIIFNINAENALLDALNKKGRFTIIENN
The following text describes a protein:
Function:
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Part of the anaphase-promoting complex (APC). May have a key function during cell cycle and be involved in cyclin B1 degradation. Triggers OR ubiquitination that mediates its subsequent nuclear localization. Involved in the repression of early light-induced proteins (ELIPs, e.g. ELIP1 and ELIP2) expression, probably via OR nuclear relocalization.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MATVNGYTGNTPAATTPAATGSKQSAPPTKTVDSHSVLKRLQSELMGLMMGADPGISAFPEEDNIFCWKGTITGSKDTVFEGTEYRLSLTFSNDYPFKSPKVKFETCCFHPNVDLYGNICLDILQDKWSSAYDVRTILLSIQSLLGEPNISSPLNNQAAQLWSNQEEYRKMVEKLYKPLNA
The following text describes a protein:
Function:
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKFLFDYFPIICFFVAYKFWGIYIATAAAMVVSALQVAIYWIRFRRFEKFHVITLIFILLLGSFTLVFHNAIFIKWKPTIVYWIFAIVLFGSHFFGKHTLVHRMLKEKIELPAKTWSRLNLSWALFFLILGVLNLFVVYNFDTNTWVNFKLFGTLVLTLVFILGQAFYIARHAQNLKMNSR
The following text describes a protein:
Function:
Putative gamma-glutamylcyclotransferase.
Sequence:
MAVRVMSSAVPDMTAPSMSTPSSRMPSSSSVEIGGRTGGVMMPMRLANPPCTLAFVYGTLKQGFSNHWLIKEVVEEGHAHFIGVARTKTRYPLVCGPFQVPFLLHMPNSGLQVKGELYAVDQSALELLDELEGTTKGHYVRRPLVLTGLQSLQVDHAPTEVFAEAYFADPTLQRGLSSAPHIKAYTKRETENYVYRKDRPKNRTFLEHVNNWIDSQGPLSYIQK
The following text describes a protein:
Function:
Required for a novel path of interorganelle communication between mitochondria, peroxisomes and the nucleus, thereby maintaining a functional metabolic interaction between the tricarboxylic acid and glyoxylate cycles. Transcription factor that regulates CIT2 gene expression. Binds to two identical sites oriented as inverted repeats 28 bp apart in a regulatory upstream activation sequence element (UASR) in the CIT2 promoter. The core binding site is 5'-GGTCAC-3'.
Miscellaneous:
MISCELLANEOUS: Present with 2190 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSSIPAGTDPGSCGANFKNDRKRRDKINDRIQELLSIIPKDFFRDYYGNSGSNDTLSESTPGALGLSSKAKGTGTKDGKPNKGQILTQAVEYISHLQNQVDTQNREEVELMVKATQLAKQTGTIVNDINLENTSAEVALSRIGVGPLAATNDDSVRPPAKRLSSFEYGGYGEYGNGS
The following text describes a protein:
Function:
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Sequence:
MLKKELSMKQELLELIRTHVYRYSEQPFTLASGRKSRHYFNCKEITLVPDRLELLCKFIVEQHLGESGILLPHAFGGLTMGADPICYGISLEFRKQNKNVYPLIVRKLSKDHGTKKLVEGSTHLVKQCVVIDDVITTGGSTIQAIRSLRDCGIEVVQGVCILDRQEGGKDAILAEGVEMFPIFKKSDFGNLEHE
The following text describes a protein:
Function:
Catalyzes the condensation of isopentenyl pyrophosphate (IPP) with geranyl diphosphate (GPP) to yield (2E,6E)-farnesyl diphosphate (E,E-FPP). May be used for squalene and possibly sterol biosynthesis.
Miscellaneous:
MISCELLANEOUS: This enzyme is unique in that it is the first reported eubacterial E,E-FPP synthase that does not have four amino acids between the aspartate residues of the first aspartate-rich motif (FARM) and that has the features of the archaeal chain length-determining (CLD) region.
Subcellular Localization:
Cytoplasm.
Sequence:
MRGTDEKYGLPPQPDSDRMTRRTLPVLGLAHELITPTLRQMADRLDPHMRPVVSYHLGWSDERGRPVNNNCGKAIRPALVFVAAEAAGADPHSAIPGAVSVELVHNFSLVHDDLMDRDEHRRHRPTVWALWGDAMALLAGDAMLSLAHEVLLDCDSPHVGAALRAISEATRELIRGQAADTAFESRTDVALDECLKMAEGKTAALMAASAEVGALLAGAPRSVREALVAYGRHIGLAFQLVDDLLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVAHGGSAGRRLAAWLVDETGSQTASDDELAAVAELIECGGGRRWASAEARRHVTQGIDMVARIGIPDRPAAELQDLAHYIVDRQA
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
TKGTSSFGKRHNKSHTLCVRCGKSSFMIQKGRCAACGYPRARKRSPGSNKAIRRKTTGTGRMKHLRDVQQRFKNGFRENTAVCYRAWPPITCAPTVHGGFCCSARSVLTIMD
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (Ref.2). In vitro binds dsDNA but not ssDNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEDDSKKEPEPEETEAEIKHEEISREEDDEGGEFSTVTISDIEMLLKDTEIWDKLLRNELSIEEAKKMFDDVARSYSKADKKKRRVEKKPKKGKVTKKSDEEEE
The following text describes a protein:
Function:
Inhibits early G-protein signaling events following pheromone stimulation. May help create heterodimerizable beta-tubulin by facilitating the efficient transfer of nascent beta-tubulin polypeptides to the folding apparatus (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTSFPASHGFGPRKRGYQMDLTNVQPVENKPAWISMKSPLEKEIANEYEALKVTERKEDTQDYNEPELHNSNDPTVDLYADTYATQAATESDSELEDALFSQLDEFDDTAYREQRLEMLKKEFARVEAAKEKGHMQFLTVENEREVMDFTLSSKKVVIHFYHPDFIRCKIIDSHLEKIAKVHWETKFIRIEAANAPFLVVKLGLKVLPAVLCYVNSQLVDKIIGFADLGNKDDFETSLLEFRLLKSSAIDRLKEESSSNKSIYHDELQNNQSDDSDFFE
The following text describes a protein:
Function:
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Shown to facilitate the reduction of insulin disulfide bonds. Might play a role in the reversible nitrosylation of cysteine residues in target proteins, and thereby contributing to the response to intracellular nitric oxide. Shapes the ASJ sensory neuron biphasic response to nitric oxide (NO) exposure; trans-nitrosylation activity might inhibit calcium flux to the cytoplasm in ASJ neurons when exposed to a NO stimulus, whereas de-nitrosylation activity might promote calcium flux when NO is diminished. By regulating the NO-induced ASJ sensory neuron activity, mediates the avoidance response to NO-producing organisms like P.aeruginosa. Positively regulates life span extension under normal and caloric restriction conditions, dauer formation and the oxidative stress response. Contributes to the down-regulation of expression of the insulin-like neuropeptide daf-28 in the ASJ neurons in a redox-independent fashion, thereby promoting dauer formation. Negatively regulates the nuclear localization of the intestinal skn-1 transcription factor in a p38 MAPK pathway-dependent and redox-independent fashion.
Sequence:
MLKRCNFKNQVKYFQSDFEQLIRQHPEKIIILDFYATWCGPCKAIAPLYKELATTHKGIIFCKVDVDEAEDLCSKYDVKMMPTFIFTKNGDAIEALEGCVEDELRQKVLEHVSAQ
The following text describes a protein:
Function:
Involved in cell death (apoptosis).
Sequence:
MYPGAGRPTYHKQQEQKGPYGQPQYQQQYAPPYPERYQQPYYQPPPHDGYSRPSMPPPSHNYAAAQYERPSCPPPGYAPHQGGFPAPGPPLQGRPRDLMRSDIQMNHSMDYSNIQGPASYTRPEFVAPPPQERQFLDPGNRSVEYQYSQCTGNRKALLIGINYFNSSAELRGCINDVQNIKNFLISRYGYREENMVILTDDQHDPVRIPTKANILRAMHWLVQGAQPNDSLFLHYSGHGGETEDLDGDEQDGKDSTLYPVDFETNGHIVDDEIHDILVKPLAPGVRLTALIDACHSGSALDLPYMYSTKGIIKEPNVWKDIGSNSMQAAMAYVTGNTGDMFTSLKSLASTVSRKATGSGGVDTERVRQTKFSPADVIMFSGSKDNQTSADAVENGVATGAMSYSFVKVMSQQPQQTYLSLLQNMRTELKGKYTQKPQLSCSHPLDVNLQFVL
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4.
Sequence:
MQHGIKRVKLSEEAKRLKLEKDQIKIKNYRQLTDEIFELRANENYSDEALIKTNELLIINPEFYTIWNYRREILINNYSSSNDKDDQIYEDILNQDLNFVLVQLKKFPKCYWIWNHRRWLLFELVKLGKVNWKYEFGVVSKLLDLDQRNFHGWHYRRFVVENMELECKNDTTLILKINLDEFNYTTLKIQKDFSNFSAWHNRTKLIPKIYNLIQQQQQKDGKIFGDLPGIELFQNPILLLKNDLEMIKTGVYMSPEDTSVWLYLYWLLTDDLFTNAFKSHQQDYMNILHEQLQLINEVNEMEKEDTGQDNVGCLKSMIFINALIQNENNKPVLTEQVKSCLKQLAKIDPLRKNKYLDQLAGNAPIFHH
The following text describes a protein:
Function:
Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.
Sequence:
MAPPAIDLLARVRPSCAALVAHESSSVHINADKVRAFVEELDPKEFAQLAEPTNFPLNFRSQQDELNFLTLYGLLNFGSGFRKDLHKYADRGAHDTIRVELVLMVGLDAQVFGLIGMYISAPKLNAQFMQHLSIDLIASYFSIPLEKDEEVSPGIYMAKPGPLKPLAVMLQKILNESGQKLVDLKMEDFGAFVLANLSPKSSGDLEEKEAVGPSASAAYLVDRFVATFPGFDDHYEFHGEKVYLLKRVQLAVACIHRRFKDSDPKLAFADIHELTALSDNVLPCVLHALGVLEYDAELEGRINRGEELPVSQQECELRAAAVVASDQIVTESKGRLDPLELDFYLWRVGKEDRFRGLERHATRDTFFY
The following text describes a protein:
Function:
Single-stranded DNA/RNA-binding protein with sequence specificity (By similarity). Binds G-rich elements in target mRNA coding sequences (By similarity). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity). IRES trans-acting factor (ITAF) that can promote IRES-dependent translation of Myc mRNA. Involved in the control of wing size by regulating Myc levels.
Subcellular Localization:
Nucleus. Cytoplasm. Endoplasmic reticulum.
Sequence:
MSMSATCYKCNRPGHFARDCSLGGGGGPGGVGGGGGGGGGGMRGNDGGGMRRNREKCYKCNQFGHFARACPEEAERCYRCNGIGHISKDCTQADNPTCYRCNKTGHWVRNCPEAVNERGPTNVSCYKCNRTGHISKNCPETSKTCYGCGKSGHLRRECDEKGGRN
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAVDRFLRQTRLSCSRGIQPTEWIENIKPNINTNALIDLILSTKPISVRLLTYYRIAIKTQEDHSETASHLIDLIPRIISQEEHDPQRILRILNPISLPLINYHNFTLNHHQAISQLQSLLQLIRLITPNQHHNQPTLSLAEHLLSALTNSILAHPANTRSIQQDILQSITTTIQDHHHHHPSQSTIYQYQLPSILRHLSPSTAKQLALNSSTTEQAPTATTTPSTTASSIIAYILLTPGVSALHSDDLEPQPILSRIISYALSSPSNFILQLFLAAISLGNSHPPSPLPNTRPKTEEIKSKEQDEDDDEDECLENDKMAWKALLAGGRLAELIRTALDTEILAKDREGIRLLGTDELVLMSQKILKKGAILDQSEPNEENRMEIENHRSYTNRHHLWFAILSSLCSNQLVLAQDLLRLDQSPSPHPNLVLGHHSDLDLGIHPLLDSLGKSSKETPISELAVKLHQSIVTATKSFDLSTCITLTEALSSLDSLSTLFLWIEPRKLLGPVRDLLDHWNDIRNNVNQLVNNSDNDESSSGSEFEKFGRLLGWLQGVVGRFSLMSNLSYHLGATTGFTIHHLSNPSTSYPISSLPASHQSTLSSWIEALYGSSGIPDDLLGHTDPRIFFSISASLFKQSFDALTIGLIDLQTFRDGLSYFEHKLLVGGCAVGVVGWLLNELTRVGRISASSYPTALLEILQSILLSDAITPTALHLVSARSLAVIRAFDASFSRAPPDHLGPGSDLNRRVQLDLGAIERRLTVLPASEMIEPAGFLAYDFGSATGWPDALDAAVRSAVRAEPDSPDPTIALWSLLPHILKAVSVGEFVQMTIRAAISASKMDDEHDSEEACTAQDRPGRIAVKVHKAWDAAKYRRVDRAVGVAVDILTWPVVGINHSGGRRPSLGPPGLVLQELFTHWGDRLGGSSSVEDAELERDIILACLDRLESLDLASTSLKKKSIPSESELPDDQSKLDPSSAMPQENRENGRGDNKLGDGERRTVTDRFRETCVTSLRRQKLRQFGLPEKREPRPVTPSRSDDLGKNAVDPFSPVSGTPMIVESGPDVPHREVGNQMDVQRSAVAEGEGAGVKELGDQEMGEKDGQEGDVKGDQQSGQKDGEQGEHNGSEKKEQAGQEKDEEGRQEKEGEQEKEKAEEGEKEDGGEKESLGEKKEAEEARGVTGAETETDDRPQEGEEGGKEAASGSADRMEVDRDADRGSEMDDRGAGSEVKKVHFLDRSAPPLARSMNGADQETSAEGDPEKKKKRKKTHAPSAALQIPSLPSTVLDWIIASLILRPVHNHLPLPLQLTPDDHFTTVLFSPDLLDHPALRFKLVGTIER
The following text describes a protein:
Function:
Probable transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWIVAGVCSGVAILLSFYLIYKHLRNYTNPELQKYIVRILIMVPIYSVDSWLSLRFVELSLYFDVVRDTYEAYVLYCFFSLIVAYIERDFDLVELLHSKEPLPHPFPLTCLPKIKLDRGFLTNCKRFVLQFVFIKPIVAIISLVLETQHKYGEGKFQVGTGYVWLTVVENISVGLSLYFLVLYYKAMEEELKPFKPLGKFLCIKSILFFSFWQSIAISFLVYFGVISPIGSWSVDNISSALQDFITCVEMVILAICHHFFFNYQEFRDPHKVPFIYDKTTKTFFNNPKTNITPIIKNFFTNVTNISDVISDTRETFILPLLSPDHHHNHPTTKKKDEESNLLEPEDKDIII
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSQPPLDELQWKSPEWIQSFGLRTDNVLDYFSQSPFFDKTSNNHVVKMQQQFSQQMPPAPQTARPKAAPSAERQAIWDRYPAYALLEQELAKLKGIEYVLAHVREPDFWVVRKQRRAGDRVTALNDYYIIGANVYQAPTAYSVVQNRLLSTGFHLSAALGAIQRLARFQPGQGAAFVPVEQNSVQPASGTTASSATAPALTAALDGATAGYSDVLTPEMMDRLMLQSLKSTPLYL
The following text describes a protein:
Function:
Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity).
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells.
Domain:
The PDZ-binding motif is involved in the interactions with PARD6A and PALS1.
Sequence:
MANPGLGLLLALGLPFLLARWGRAWGQIQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVGLALLVRKLREKRQTEGTYRPSSEEQVGARVPPTPNLKLPPEERLI
The following text describes a protein:
Function:
Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (ctnnb1) nuclear localization. Required for appendage regeneration by regulating cell proliferation.
Subcellular Localization:
Nucleus.
Sequence:
MCVAMVIIHTKTLEKKAVDDVTSEASLQPQEPLTMSQGTALFSCGIMDSGRWADVGSVCGVQQRPVGSSLESLWDSMREAGATGGISGLLRDLSLSEASPASAAPPSKRQCRSLSCSDELGCRSSWRPQGSRVWTTVEKRRCHSGGSVQRGVFNPSGFPAMQRSSSFSLPAHSSHLEPFTHGFPFQAFSECPQTPQTLYRSHEQICPAEASSPESTPELQRRSGQSGLARSRSQPCVHNHQKIGVKRRRPADSHKQRPSLDLLKMTQKLQDFHSLSCPGFSGDDKTLPSSSPALLNDTCERAQNDSSADAPIHQSESSSEDALIHQSDSSSADALIHQSESSRPAGKERECLWAGLCSRRGRDLFQLGGELDIEQIERN
The following text describes a protein:
Function:
Transcription factor that binds to the promoter and the enhancer regions of target genes (By similarity). May act together with the bZIP transcription factor, cebp-2. Involved in responding to mitochondrial damage. Plays a role in the delay of age-associated mitochondrial fragmentation and muscle decline. Has a protective role in response to infection by the Gram-negative bacterium P.aeruginosa. Required to prevent P.aeruginosa ToxA-mediated lethality. Required for the activation of several infection response genes including irg-1 and irg-2 following P.aeruginosa infection; target gene activation may involve effects of the bacterial toxin, ToxA, and perhaps other toxins.
Subcellular Localization:
Nucleus.
Sequence:
MEPLSAPLAVGFSAWPPSPPLPPLAHSPLQDAVHADHNHRRILNSCRNLPDCLTTTVPQLHQINSAEQSPLQFTHQPNCDLIVVLDEQTTYTTTMTRRSLPKADRYLSEPNMSTPQASHGSFEFDVPEYTSFDYAFDFPPVPEAFPPAANSSSAASPDADFLDLDSLMSCDITSLDAYIHDDSIASPSNASHISPPASDIDPVDEFFPQLVHNNKIQSSSSSTVETTITRGRKTSSVSSDSSSDYRHKRDKNNLASQKSRQKRQAKIRESKEERERLEKRKVQLQAMVLTLETQVEDYKRLVMMFVKR
The following text describes a protein:
Function:
Participates in the sulfur mobilization (SUF) pathway for iron-sulfur (Fe-S) cluster biogenesis. As part of a complex consisting of SufB-SufC(2)-SufD, involved in assembly of [4Fe-4S] clusters. Exhibits ATPase activity.
Subcellular Localization:
Plastid, apicoplast.
Sequence:
MKRRKWLNITWAVTIYIFFGMINVSSYNEGRKRKNKMYSFVINGYNEYKNKYSFLRKPKNVVHMENNNFDMDRLSLLKNLEEESKIITEGEGWDKTHPLLEIKDLHAIEIEGEKEILKGINLEIYLGEKHTIMGRNGSGKSTLAKVIAGHPYYKITKGIIKYKGLDLINLPVNVRSLCGIFLAFQYPVELPMVKNNEFLRAALNSHRRHRNEEEISVSEFNLMMIEEIKKVGLSSEFLDRPVNYGFSGGEKKRNEILQMLILKPTFCILDETDSGLDVDSFKLTSNVITNFSNDNNSFLIVTHYKKLLELLKPNFIHIMHQGKIIESGDFSLVDKIENKGYSQFLKE