lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play a role in mRNA degradation. Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.
Subcellular Localization:
Nucleus.
Sequence:
MMGDNVSNNITRGVLHLVVDSAGFIRNAPLKDLGENIYTIQEVVSEIKDPATRMRLQVLPYDLNFRCPSHDSIKAVTDFSKKTGDYQSLSAVDLRVLALTYQLEVEHVGKDHIKTASTKTVKCEIKNSRTDPLPIGFYSSKKQKTTTSECQNEILTPANTPAQQHELNDDNNNNNNEEDVGKNIIINNTNDDDGNKGNNTSDVANICTNNNNIYNGGNYSFERNNDDSDGKFGIDICKLSLALKNAAKKDGESDENEERDDDDGDKEEETCSADDSHDDDDNDDDDKSESEEDFEGETTMQGDVANEGDDDDEEEEEEEEDDKNKDDDDDDDDGGWVTVSNIKSLMKSNPNQHINTVNEQIVVACLTTDFAMQNVLIQMGLRVLSVDGLLIKQTKNYVLRCHACLKITKNMMKKFCSHCGNQTLQKVSMSIAEDGSVVCHLSKYKIPSARGTRYSLPMPKGGKYNHDPILCEDQLKTKQRTKKMSKVVDVFDPDYLGLSSPFALNDVTSRATSLGFNKKSRRSDVVDVFDGRRKNPNESRKKTGRRK
The following text describes a protein:
Function:
Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPPRGDGQRPRDRRLRGMVLSGGFPSKWLFGAIAGGRNPSRDQQIGRLGVSGSGPPAAPPPPKGLGAGGAAMERALAANWSAEAGNGSEAAPAAQGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRALRRRADRLAVLATWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYVTWITLSVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAEGREGAGRAALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDADAPKEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSSSYLKGNRPGETSVSKKSNSSTFVLSHHSSSQRSSSQPSTV
The following text describes a protein:
Function:
Binds specifically gamma-aminobutyric acid (GABA) with nanomolar affinity. Does not bind structurally related compounds such as 4-aminovaleric acid, spermidine, histamine and butyric acid.
Subcellular Localization:
Periplasm.
Sequence:
MFKSLHQYAHVFSRLSLFGLAFAAAAQAQSQSLTVISFGGATKAAQEQAYFKPFERSGGGQVVAGEYNGEMAKVKAMVDVGKVSWDVVEVESPELLRGCDEGLFERLDPARFGDPAQFVPGTFSECGVATYVWSMVMAYDSTKLARAPQSWADFWNVREFPGKRGLRKGAKYTLEVALLADGVKAEDLYKVLATPEGVSRAFAKLDQLKPNIQWWEAGAQPPQWLAAGDVVMSAAYNGRIAAAQKEGVKLAIVWPGSLYDPEYWAVVKGTPNKALAEKFIAFASQPQTQKVFSEQIPYGPVHKGTLALLPKTVQEALPTAPANLEGARAVDAEFWVDHGEELEQRFNAWAAR
The following text describes a protein:
Function:
Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGFLDVLYQISQRLSKDNLNSLKFLCVEDIKKKKLEQIHQGTELFQCLIEMNKIGPDSTEFLHYLLGHIDRQDLIELLQKFERDGPAGLNDNQPDVKEREKLDAAFGVIVENMGRDWRMFARKLGITDAKLDHIREKHPFNMEEQVREVLRVWQKSKGKEAKVMDLIEKLRECKMNLTADFVEKELDSMKNFC
The following text describes a protein:
Function:
Required for normal Golgi function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MINNELKDIFSSNDFNSKTWINNLLSDCGGSGSSSGNAKSNQQSILTDQNNIKAELEIENICSNYLSKLQLYQIELNISLESITSESLLIVPKSIREVDRIRKESLHLKNRIKSISSKIGEMNNDSPQSMETVSVIEKLDQVKSRMEISIRSLKEAEKLLSFSKTVDQLFSSNDYLMISDKLEEVKQSLSVLSDVPEFREQSKKFNVYQDRLESQLKQPLQQSLQQKDLESCKNYLKIFTNIQRQDKFFIYYYQVRIDPLKLLWNSYSSSSSSSSSSSNFHNWLSKFYDEVLVMINSEFNWLSGLCPIDYIQVLENLIIHLFTTINPNVQSRIDQAITIANQTTQQPIKVNELLSIYKTTCSFLKSLSPIFPNIINSSSTPTTSPAVDKLFKVIFEPYKYFQNKFSEYEIKSVKSQLQSISPILTLQKKSGGGSGGSGNADFTNIIKNIENQFIPKSFQIAQQSIERFFDFTHTTDIDSYVNTVLNQIFTEISLILRDTINELKFITGLTTNYIIGSSGTFPNFNQQQQQINTPSSINGEVDPVKKLTNSHTRSHSRSGSGSGNSNSNSVGTSATLQNWEYFQGAMNLLQSIHQLLNKFQQFDNSTSLNIIHYLGNSNNSNNSSSNNDNDQFICNIRKFLLGKDLNKIQKLQISVQNLENIISSPLPLSSSSSVSKDQSISKKPLLLQESFNQISKLLSISQHFVYETLIYFIKLKLKELPKIVSNEWNNNNNNNNNPSQNNGGGGGGGLSYISQITDHLLTIPQQLDPYSEEELTRFSLSTSLQYPIKTCSNSEDDFYQNLLIQYQREKQFDDEQLLIEKLKEKQEQQQEQQEKEQQQEKEQQDADQDININTNNNNENDENDEDDELEDGIAHQWITIVAKATEKLYLQTIVEIITLNEPSCQQLSNDIGYLFNVLSALGVSAEPLLQKTQSLLEMNRDTFTSFYHQQLHNNNNNNNNNNGNSNNNNNNTNNISLLTNAEKNICNLIGKMRNIK
The following text describes a protein:
Function:
Probably part of the ABC transporter complex MntABCD involved in manganese import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIGDAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGIVLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCIVFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPAITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMICAPKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLKALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDYFDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF
The following text describes a protein:
Function:
RNA-binding protein which binds to RNA with no sequence specificity. Probably represses translation of specific mRNAs (By similarity). Essential for the development of primordial germ cells (PGCs) by ensuring their proper migration and survival but is not required for PGC specification. Also required to maintain oocyte production in the adult ovary. Negatively regulates phosphorylation of myosin mylpfa/mylz2.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region.
Domain:
The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
Sequence:
MAFSLLQFILSAHGSMETRNQDFQPWKDYMGLADMIRGMKRQEMQSDADSDEQAAALLESPSGPIRSRDSPEQNTSPGGGKPKSSPAERKFCSFCKHNGETEAVYTSHYLKNRDGDVMCPYLRQYKCPLCGATGAKAHTKRFCPMVDKNYCSVYAKSTW
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Sequence:
MSLTKGSKAAQDVISFLHTVGRLKVTARQGWVENQICSPESVSDHMYRMSLMCMMCPDTSLNRDRMVKMALCHDTGESIIGDISPAMKVPKEVKKQQESQAVQSLCKLVSSSPNTTFSKELGDLFEEYEAQETAESHFVKDMDLLEMVVQAHSYESANPGKDLGSFFRSGANIHHPWARAIYETLLETRPYLAYKEEQAKEASSI
The following text describes a protein:
Function:
An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or complete starvation by inhibiting TORC1-dependent cell growth and promoting catabolic metabolism and autophagy. GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development. After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition. At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development.
Sequence:
MKLYKLNTHTRGCNKSYDADLVMNLKDHPNANVGDVVEIYAPDEENGTHLLLQITEFNGSCGRDVISIESGIANAFKMRPYSNVVMRIVKPADVALDSIEITFKDQYMGRSEMWRLKTYLTDTCVYVNKKIDYNDMQIRCQVYEMWSQGERVASGVITEDTKIVFRSSTSMVYLFLQMSSEMWDFDIHGDLYFEKAVNGFLTELFQKWRKLSCNHEVTIVLFSRTFYAAKSLDEFPEHMRDCLQQDYKGRFYEDFYRVAIQNERCDDWCTVLGQLRKLFTSYQATVLRYHERENMKIPPATNSSATQGNFLEVLNISLNTFEKHYLDRTFDRTGQLSVVITPGVGVFSVDRELTNITKQRIIDNGVGSDLVCVGEQPLHAVPLLKFHNKDTTLTSADDYSLPHWINLSFYSTNKKIVYSSFIPRIKLPLFGSQLTLHDGVGDGEGEENERHFLSCNQSEYKHNSLFDYDAYDEQIFQPLPAQSTCSLQRVVRAKKTSVPSLETYAYRNNDWENLTPTQIPAMRRKMSDPDIHHGTSAMLAALQPDTTNLSESLASEKNSRRTIVSIAPIVRPGRALINPFDPSQVTIKLTSNRRRWTHIFPKGPTGVLIQQHHYQAVPAKPTQAGQQRPLQQTQSNNNNDQEDYGCENGEQYDRVSSHSLLNKSDSSQSFVMGDEPIDFFKRRQNSPMNPQPANVPNLTATQAKSYLWGATGEQEWTPAITTVKHLRPIVEGEHHHLGSLEALRALDPPPDAEAGGGRGKIIIGVDWKSLTIPACLPITTDYFPDKRSLNNDYVISDYTLLPDDVNHDYAQSRAVYRKPLSTEEVCKEIVSQRLAQGFQLIVVDEKPPTASGCSSGSAVQPVKLSRETNKEYLLSIGRIFHKISLSGSVITVTGYRPRHPYPPINVDYRYRFHAPQHETYEISGVNFTTEKLENFNWNHMDLYICTRGDVDYPLMESLKYWRYRMYLLPRENIVSKIASCQRCDIFPDVTADNTREQVEDFVRLIEAVSKLKRQYARKARYLASLLQDSPIAHITKRRHSTSIISRPQPNQGLTNSPFRERVGSNRLPEKRPSINVRPKLENGRIPRIFPATDAAAAAGVAARDDQDDGFPVDIKFSPNATLPEIFEAMKHPVNGVGFFSQTQSLPSCTFVSYDALMWLKTRLNNGRHPLDLLEAMRKERMICHASGDWKKPVVPGFVFYYVVQQDKNAKDYAPPLDDYSAFVNEWLEIEFQGCSFLWHDEPVTTPVPNFLRDSPAPQSWTETSSNKRVYRQSHLEIDVNQKSDRMEWGHVKHHTVLQPRFAFEIVVEWVTSSGPIVADLIGGWMRKANQFNFLVSVPADPMAEPFTKKSDPLRGPIFIPLCTTFLPNGAALFDEFPEESRSDRMLFFQEAILGKFGFLPCVLEKKYSVGKDLPKEYQYVHCTGNMFALIRCATNNYQVESPILKEANVTRCVYGHTNNTNVPKKVGFLWAWNHMIPNKKWKAQTINNSADGELFQLKMLKDFREFCSNSDQRLSTFWTQSQELKRRAQKFEFNNNNTEENKMK
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MINNKGNVGKGKRIFNKNYGSISKKKKKRNDKLKKDVSNNKDERLELQKRIDETLGLIVEENKRKQYEEKINNDLEKNENVKNFLKSDKTNNNTYDEDELKNNKNKKYKNNLTIIDKNVLTSAEFKTLPISKRTLRALNENNFIYMTNIQYVSLPIVLLNKHIYAQAQTGTGKTLCFCIPLIEKMYRNSIDNYNKILGGIIITPTRELVFQIFEVLNMLNKYHKLNICCAIGGKNEEKEKSIFSYANIIVCTTGRLLYHLENNYYCNLDYLSTLIIDEIDKLIDKSFYDNLKNILLYKPKENCQICLFSATICKFLNVILNTFHIKDYEYVSINDNDKYIESNNVKQIYIECDIYEKINYLYTFLFSKKNKKIIVFFSTCKQVRFMYEVFKKIKVGVMKFLQLHGKLKQTSRLNTYHFFSKKKNFVCLFTTDIACRGLDFSSIDWVIHFDFPDNIETFIHRSGRTGRFTNMGNSLIFLTKQIDNKKLFLNVLKDNNIFIKEKFIKKQKLFDIKNKIHSLNAAFVDIKHLAKKALIIYLRHLYIVMKFKDIKKKIQLNELAYSYGLIEFSQDMINELNINDEKEVQVKKKKSRLEKFLEILKNKKALKNKQNHEKKEEEKYNNTQDEKEYDNDNEQGHEIYDEAHENYMCEIKKKKRVKDISHIDQSQSNENPFIHSDIQSDQDDLFIQKRVEIKDDTPIMLPTKKRKKRVKVAKTLSNSILYDDSGNEIKDDNVKFKILVNELNQNEDHDMEQDTHYDDDDDNNNNNDKYDQKTYIESLKEKIQRDNEKMKISKLRKKKDFIADRKKHEEDSSSTDNTNFSDIQDKDDLEYNESSEGDNGNYNESDDFVKNKKKISEKCDPTDDISDLENKVMMFL
The following text describes a protein:
Function:
Plays an essential role in chain termination during de novo fatty acid synthesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASLGLMSVCASASAGRFHRSSSNSALVLCKLPVPSSIERDQCRIPTFAAGETTTANLRQLSSKLNALSVRESQHGGNTNNKPVDICRDKTVGEEDFGLSRDGSVSNLNLGADDQVTASCGNSLSYDKKEDIRIRRQLETLAALRQGRILGDSQIFRQTCVIRSYEVNAEGRTSVDTILSLFQEVALNHVSLLGISGTGFGATKGMNENRLIWVITRLHVEVDRYPAWPEAVEIDSWVAKSGKNGMRRDWLLREYSTGHVIARATSTWALMHEDTRRLAKLPDVVRDEITPVFIERCALHEGVFDRISKLDDTADYIKLNLTSCRNDLDVNKHINNVKYMRWVMESVPPSTSETHELSTVTLEYRRECQLEDIVESLTNSTAVVGNMHPYQENRVQSCHHIDGTAIPSGSNKTSQIIPNSSDREQQQQQGSELQSSTLQYTHLLRKQSNSDEIVRGRTVWTAKSKKSKNLEHDRTHS
The following text describes a protein:
Function:
Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (By similarity). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). Promotes the survival of quiescent T-cells. May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation. May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity).
Subcellular Localization:
Lysosome membrane; Single-pass type IV membrane protein. Endosome, multivesicular body membrane; Single-pass type IV membrane protein. Endosome membrane; Single-pass type IV membrane protein.
Sequence:
MEDHGFEELSTRTHDLNVRRLTKGNINFLLSTGQETYSVEDSGLLRILLVGKSGCGKSATGNSILRRPAFESRLRGQSVTRTSQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNCYLMCAPGPHVLLLVTQLGRYTVEDAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESLEEFVTHTGNLDLHRLVQECGRRYCAFNNKASGEEQQGQLAELMALVRRLEQEHEGSFHSNDLFVYTQVFLRGGYSEHQEPYKFYLTKVRQEVEKQKRELEEQEGSWMAKMLCRVTSCLDWHIAVSVLLIVLGLTLLITLINMYIGRWK
The following text describes a protein:
Function:
Probably involved in the regulation of pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MAQYKGAASEAGRAMQLMKKREKQREQLEQMKLKIAEENVVKANINKKFSAHYDAVEAELKSSTVGLVTLNDMKAKQEALVKEREKQLAKKEQFKDLQLKLEKQRERERKKEQKRKIASLSFNLEEDEECEDEESEEEEEEYVADKEDLPKKKKKKKQQLGKNPDVDTSFLPDRDREEEENRLREELRQEWERKQEKIKSEEIEITFSYWDGSGHRRTVKMKKGNSIQQFLQKALEILRKDFSELRSAGVEQLMYIKEDLIIPHHHSFYDFIVTKARGKSGPLFNFDVHEDVRLLSDASVEKDESHAGKVVLRSWYEKNKHIFPASRWEPYDPEKKWDKYTIR
The following text describes a protein:
Function:
Involved in transport of proteins into the mitochondrion.
Subcellular Localization:
Mitochondrion outer membrane.
Sequence:
MGGLTKFSSYFHSIFSRFPLITFSNPYPGENEDYKTKTVMYLTMWNSDLNSEALDVNSLQWQTWAKLNDPSIVFLNVSNHASPDEKVPFIQIESRKLVLNPSLLQYFLKDESTLQQISPWMSLLINQVETAILLTMYLDNENFSEIQKKWLPNMSWPLNIIKSIGLPSQIKRKICLQLNESTLDFDAILEDASKAFSALSELLGSDKWFFNNESPSFLDVSLFAHAEIINHLPLKNDQLKVVLGTHKNLTDLTTRVRTLAGYTSAGPIALR
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for oligopeptides; probably an oligopeptide binding protein.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MKKSKSKYLTLAGLVLGTGVLLSACGNSSTASKTYNYVYSSDPSSLNYLAENRAATSDIVANLVDGLLENDQYGNIIPSLAEDWTVSQDGLTYTYKLRKDAKWFTSEGEEYAPVTAQDFVTGLQYAADKKSEALYLVQDSVAGLDDYITGKTSDFSTVGVKALDDQTVQYTLVKPELYWNSKTLATILFPVNADFLKSKGDDFGKADPSSILYNGPFLMKALVSKSAIEYKKNPNYWDAKNVFVDDVKLTYYDGSDQESLERNFTAGAYTTARLFPNSSSYEGIKEKYKNNIIYSMQNSTSYFFNFNLDRKSYNYTSKTSDIEKKSTQEAVLNKNFRQAINFAFDRTSYGAQSEGKEGATKILRNLVVPPNFVSIKGKDFGEVVASKMVNYGKEWQGINFADGQDPYYNPEKAKAKFAEAKKELEAKGVQFPIHLDKTVEVTDKVGIQGVSSIKQSIESVLGSDNVVIDIQQLTSDEFDSSGYFAQTAAQKDYDLYHGGWGPDYQDPSTYLDIFNTNSGGFLQNLGLEPGEANDKAKAVGLDVYTQMLEEANKEQDPAKRYEKYADIQAWLIDSSLVLPSVSRGGTPSLRRTVPFAAAYGLTGTKGVESYKYLKVQDKIVTTDEYAKAREKWLKEKEESNKKAQEELAKHVK
The following text describes a protein:
Function:
Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTSLPAARYLVRSVALGYVFVLLIVPVALILWRTFEPGFGQFYAWISTPAAISALNLSLLVVAIVVPLNVIFGVTTALVLARNRFRGKGVLQAIIDLPFAVSPVIVGVSLILLWGSAGALGFVEQDLGFKIIFGLPGIVLGSMFVTCPFVVREVEPVLHELGTDQEQAAATLGSGWWQTFWRITLPSIRWGLTYGIVLTVARTLGEYGAVIIVSSNLPGTSQTLTLLVSDRYHRGAEYGAYALSTLLMAVSVVVLIVQMVLDARRARAVSEG
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLEFLFKFGKFFAFTPPSLQIKAPTKSEKIWAFFIIFFHTVSLAIAMYYRAGYYSQYIHLNLVITAIIDSSLYILNIYIIVVSLTQRSDWLILIQSLGVTKKRTKFWWFLIFNLLFWTVIINMSYTFTTLHSWEFYKKYSNEYFLLYVQFLTSVLVCTILGKLKSRYESIKGVLIYHISRARKFNKSNFSLVFLQSLKYDLSVLKDGVDSFNVIFGWPFLLIFIFVSLQDLAYLDSFFKLKNPTVVLSNFLMMAMITLEIAVPIWLCDLVVLESEEILAASYRLQRYLNDKENSELEKFIKVAKANFPKFSAARFCLIERNTLYKIFETVSTVLIIMIQFNPDLKRNVN
The following text describes a protein:
Function:
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
The following text describes a protein:
Function:
With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).
Subcellular Localization:
Lipid droplet.
Sequence:
MKMPSIIQIQFVALKRLLVETKEQMCFAVKSIFQRVFAWVMSLSLFSWFYVNLQNILIKALRVGPVPEHVSFIMDGNRRYAKSRRLPVKKGHEAGGLTLLTLLYICKRLGVKCVSAYAFSIENFNRPKEEVDTLMNLFTVKLDEFAKRAKDYKDPLYGSKIRIVGDQSLLSPEMRKKIKKVEEITQDGDDFTLFICFPYTSRNDMLHTIRDSVEDHLENKSPRINIRKFTNKMYMGFHSNKCELLIRTSGHRRLSDYMLWQVHENATIEFSDTLWPNFSFFAMYLMILKWSFFSTIQKYNEKNHSLFEKIHESVPSIFKKKKTAMSLYNFPNPPISVSVTGDE
The following text describes a protein:
Function:
Structural component of the bacteriophage tail which consists of a contractile sheath, a tube and a baseplate. The central cylindrical segment of the tail consists of a rigid tube, composed of multiple copies of gp19, surrounded by the outer contractile sheath assembled from gp18 subunits. A total of 138 copies of gp18 arranged into 23 hexameric rings constitutes the sheath. During infection, contraction of the sheath drives the central tube through the host outer membrane, creating a channel for DNA ejection from the capsid into the host cell.
Subcellular Localization:
Virion.
Sequence:
MTLLSPGIELKETTVQSTVVNNSTGTAALAGKFQWGPAFQIKQVTNEVDLVNTFGQPTAETADYFMSAMNFLQYGNDLRVVRAVDRDTAKNSSPIAGNIDYTISTPGSNYAVGDKITVKYVSDDIETEGKITEVDADGKIKKINIPTGKNYAKAKEVGEYPTLGSNWTAEISSSSSGLAAVITLGKIITDSGILLAEIENAEAAMTAVDFQANLKKYGIPGVVALYPGELGDKIEIEIVSKADYAKGASALLPIYPGGGTRASTAKAVFGYGPQTDSQYAIIVRRNDAIVQSVVLSTKRGEKDIYDSNIYIDDFFAKGGSEYIFATAQNWPEGFSGILTLSGGLSSNAEVTAGDLMEAWDFFADRESVDVQLFIAGSCAGESLETASTVQKHVVSIGDARQDCLVLCSPPRETVVGIPVTRAVDNLVNWRTAAGSYTDNNFNISSTYAAIDGNHKYQYDKYNDVNRWVPLAADIAGLCARTDNVSQTWMSPAGYNRGQILNVIKLAIETRQAQRDRLYQEAINPVTGTGGDGYVLYGDKTATSVPSPFDRINVRRLFNMLKTNIGRSSKYRLFELNNAFTRSSFRTETAQYLQGNKALGGIYEYRVVCDTTNNTPSVIDRNEFVATFYIQPARSINYITLNFVATATGADFDELTGLAG
The following text describes a protein:
Function:
Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MQQQPLPGPGAPTTEPTKPPYSYIALIAMAIQSSPGQRATLSGIYRYIMGRFAFYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSYWTLDPDCHDMFEHGSFLRRRRRFTRQTGAEGTRGPAKARRGPLRATSQDPGVPNATTGRQCSFPPELPDPKGLSFGGLVGAMPASMCPATTDGRPRPPMEPKEISTPKPACPGELPVATSSSSCPAFGFPAGFSEAESFNKAPTPVLSPESGIGSSYQCRLQALNFCMGADPGLEHLLASAAPSPAPPTPPGSLRAPLPLPTDHKEPWVAGGFPVQGGSGYPLGLTPCLYRTPGMFFFE
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.
Sequence:
MENNSHNVDERRAARMRGAERYKIQNVEFSLDQNLLANLESSTSSSTRSSPASNQQNLEIVSQSEAYHKISDLDDSTSIFSISDQENILERRISEEVVRENSVSSIENVSSSAVARETQSSANILVKDNHFFSHKQKKIQRESIPFHKRDNIETSDAYSSSILENSPPNKVQRLSSLDSSQDSFQEEHPGNVTGTTFSSQAPEERIASPISTSSPESLTNQSSSLQSSLQTSSMAPRNLLDQSTEKDIVVGASDELVRIELTKLSKEAGGSKTLNELDAVQQFFQEFIKENEPLEPYVVKVKNAFVEQVSIRLLELIDLLDANRILSTACKKAANEKLAVQRDLSKLREDRLSVQRKKIQLRNEYIKLSHQQNFLDDIDDFFSQCETVKNELENVTTTPNSTEAFSEINEYASALSKNYGLESQLVELQSLLTQFYQKFLS
The following text describes a protein:
Function:
This polymerase is devoid of exonuclease activity.
Sequence:
MGRTQPSYTMAVNRELEKLERIIERLHSPILSLLLERVKEKVRYTQSASYDELVDPYNLVYFALIWALAEECEKMEEYVLDAYPIKGGVKLFLSNFKEKTIRTTFPVYTITDNPDIVLQHPEVRYYEKEKWKTLDGKEVKVYRFEVESLDAYYYMRKRLNVVNETPTVLSQTLYRLGIKPFRRFRSSDDEFPKVTIARVVPLDWYGESLKGKVFEVKINNEVRRFYEKPEVEVDIAECLGEACNYVKSNVKIRIEKKRSPVSAKGLIEWSFISLTPIHEIAYATIGKVLTINEAWVAFKRRIIIPKVVPRVEKLRRLEDIMMVDKGGLILFPQPGCYDNVYQVDFSSMYPSLIVKHNISAETVEACDDIKTELHSICLKEKGIIPEALQWLIERKSELKKIDEERAEAIKWILVASFGYLGYRNSLFGKIEAYEMVTYLARKTLRRTMEIAEEMGLRVLHGIIDSLVVKGDNVDKFIEKVEKETGLRLDYKRYNWIIFTITRNNTPYPTRYIANMNGEMIAKGLIRENMPNIVKSFLEDVLREFSSAKTCSDVKKLRIRDLFEHYRKRAINGEPIDYVIWIKDVPYVRGIKGFYEARLGYMGRDVNYYINYLKRVYEDVEEVMSRC
The following text describes a protein:
Function:
May be a general transcription factor. Plays an essential role for RNA polymerase II/ama-1 transcription in early embryos whereby it activates a subset of RNA polymerase II promoters and facilitates the reestablishment of transcription after mitosis.
Subcellular Localization:
Nucleus.
Sequence:
MQMGDHQMMGNQRYYRTYVQKVMPAQAGGAVSQNATYVQTAGIRTVHHDGNGQQRIVQLPPGVRQIQQNGVGPAYVRQVPGGQPMQVNFGHPGTIAGRNVAVGVQMRPVQGHNVQQGYQRQQVANQIQQQNRAVFMAQNQQGQQQISYAQAQHRQQQQNQQQHHQQPQHFNHPSQQNQMIMQHRQPQMHHNQQHQMVQPQMTRHQMAQHHAQQPHPQIYVPRDMNLAVPLREPSPEPIPVKIEVPDVPPEGTSAANEEPMPDDGDIDIQIRNVVCNYTLPLHIDLRKLAMNTHNVTYEREKGVMMKQKRSPGCYIKVYSSGKVYIVGCRSEADCKRAARSIARHVQRVMGKTKERVSIRNYRVNNVLATCRLPFGIKIEEVAAKYPSESTYEPELSVGLVWRSVTPKATLRIHTTGSITVTGAQSEADVLEVLSKIYPIVLEFRCLERAKGNVAAQKKRKRKAPVNRGPPIKRERFDDSNYRNSGVINNQVYFSDEDEDLYDELDLEE
The following text describes a protein:
Function:
Required for xylan biosynthesis, but not directly involved in catalyzing the addition of sugars to the growing polymer.
Subcellular Localization:
Golgi apparatus membrane; Single-pass membrane protein. Note=Also located in an unknown intracellular compartment that may have some role in the transport of cell wall polysaccharides into the cell wall.
Sequence:
MKNGSGNTNTKLILLHPYIQKQTSTTRLWLLAFVSFFTIVFLLTLLYTRDTIPSKNTSVAAAVAAVVTGGSTPSASSPISNSNLPTSAINALLHYASRSNDSFHMSYGEMKSISDVLRRCAPPCNLLVFGLTHETLLWKSLNHNGRTVFIEENRYYAAYFEEIHPEIDVFDVQYTTKAHEAGELVTAAKEAAGNECRPVQNLLFSDCKLGLNDLPNHVYDVDWDVIFVDGPRGDAHEGPGRMSSIFTAAVLARSKKGGTPKTHVFVHDYYRDVERLCGDEFLCRENLVESNDLLAHYVLDKMDKNSTKFCNGRKKRSVSSLS