lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MQWAFSNKVAGSSQLLSFKAFGEERPKKIIHDSQTSSGSMTTQIPDVSSSKWKLQSREPQTSTIDDKKAPEKCALTIYPQQHLNGISVLYPQEVKIFSGSNRPNKTASLPSKTPVFQSNFSSVRENMVCSTVNSQPVGGVLVLPPVSLLPSTSATVGYTDYRSVSKPPKMPAQMTIFYAGSVNVYDDVSPETAQAIMLLAGNVAHSKTLATTQGQGQGAISRITTDESSRGNQPQNISAFLGLPNLVSVTSQSGSPSGGKSSCDNDAATRKPLGSFACPVNKSETSKVITPIRHGAASLLPPVALPQARQASLARFLEKRKERVISSSPYAVSKKSPDCSTSTSNEISFSILNSSVPCPQSVAK
The following text describes a protein:
Function:
Plays a role in the regulation of chondrocyte maturation and postnatal endochondral ossification. May inhibit cell growth stimulation induced by FGF2.
Subcellular Localization:
Membrane; Single-pass membrane protein. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note=Appears as reticular-like structures throughout the cytoplasm and adjacent to the plasma membrane. In proliferation and hypertrophic chondrocytes, detected intracellulary and in the pericellular extracellular matrix. In primary spongiosa, detected only in the extracellular matrix.
Sequence:
MASCLALRVALLLISGVLAPAVLTAEGPQEPDPTLWNEPIELPSGEGPLESTSHNQEFAVSGPPFPTSAPAPEDSTPPARVDQDGGSLGPGAIAAIVIAALLATCVVLALVVVALRKFSAS
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Sequence:
MGALCSSETYMLDKETYKKQVEHNKMIEQDLDKDRKLKILKLLILGPGESGKSTTIKQIKIIHDEGYSVEEKLIRRHGIFMNILEGIEEIHLAVGRENKSYKNPLSFDHIHEVRMFTENFKKADEADKILGAEVINAIQKYVKDETVAMMLRDKTVYNIDDSTIYFLDNFSRIIQKDYLPTEEDILKSRVPTSGVIQYKIMLKNFNFKIFDVGGQRAQRRKWLHVFDDVHAVLFITSLSEYDQVLREDATVNRMKESLNLFEKICNGRYFINTAMILFLNKIDLFEIKIKHTNITVALTSYKGPQERDSALDYIRKRFVSLNKNKKRSIYEHVTCATDTEQIQVVIDSVIDVVIQHTMQKVGIQ
The following text describes a protein:
Function:
Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Sequence:
MSLRRAATLFARSFAESASSLPVEAGVGARLCTGASTSGRQAWPGAAAGVYARGPVAWSAGPAAAGTRSAHSRSSTKYTPAELGLYWGAAAVFMVGVSYASVPLYKLFCAATGYGGTVRAGESVEEKLQRRRDAPNAKVEEAASKRELRVWFNADVADDMPWDFRPTQEYVRVRPGQSTLVFFTAHNKSDKPVTGYSLYNVTPDKAAFYFNKIQCFCFEEQRLRPGEQLDMPVFFYVDPEFATDWNCRNINDITLSYVFNKVEGEEDEEDDGRPSVVKLHSGPHPAAAAAAAVGMPMPVPVAVAAAAGTAPRAA
The following text describes a protein:
Function:
DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA.
Subcellular Localization:
Nucleus.
Sequence:
MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVAAYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLACLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQAFTRKEIWCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFRILALTATPGSDIKAVQQVITNLLIGQIELRSEDSPDILAYSHERKVEKLIVPLGEELAAIQKTYIQVLESFAHSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECVFARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVVILSEGREERIYNQSQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQAQFSSLQNEENKPTQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYLQMEDVTSTFIAPRNESNNLASDTLITHKKPSFIKNINQGSSSSVIESDEECAEIVKQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRTSDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDVHKHNQNENLVPNNRVQIHRGPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFDDVSLSPLNSKSKSLPVSDKTAISEMPLVSQFLISDELLLDNNSELQDQITCDANSFKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLEIKEISDGNYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSEVDSPLHAVKKRRFPINRSELSSSDESENFSKPCSQLEDFKVCNRNARRGIKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSEMRAIYMKSLRSPMMNNEYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKQMMEQNCAHSKKKLSRIILPDDSSEEENNVNDKRESTIAVNPSTVKKNKQQDHCLNSVPSGSSLQSKVRSTPRVNPLAKQSKQTSLNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRPHLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLNQDRLKSDI
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEVRSNKIAKINFNFLLQSFENSAIYVNIIKPIAKYSLYLGISPFTTKNGQIVLSRIRLVPSTILVLTNIALTIIYSTSFGETSDFTKAETIKFLTMFRDLGSTTMMVLNLFFSQMYFTKKLEQMRQVHEVDNQLKQMGCDLDIPNSVVQKHLILLMVLVNLIFNTCGEVFSAWVRCQDQILIFLVNWYPRLIIGIMNSTLNLIFLLIQTRFEMINNIITRGDVTSTTIKKLFNLHKILVKVVREINGIFAFQVLMCTSMNFVLLIGDLHTSIYIIFFDMFYQHHKIVLDMGKNCVTYVFDLFYLSKRASDLCNEANKTKILLVGLKIDIDQEEERNVVVTSVLKLMQNKLEITACRLFSIDNALLFSICGAASSYLFIMLQLDIGSKTQGTNSTLY
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MDSRQLRYFIAVYEQRNLSRAADQVNVAQSALSHHISNLEAEFATPLFERKSRGMEPTAAGERLYEHARIILRAMAEAETEVREGARVIAGEISIGMANSGVKAIGVELMRTVLTKYPKLKLSLTESLSGATLMHLMVSNVDLALVYNPPSEKELITEPVLEEEMFLVGIPKLVGKGKAPIRFEELSRMPLILLRYGLGLSSRALLDDPVLLKRLEGGAILHANSITGMTGALVEGLGCTIATKLFAREELAAGRLIARKVIEPKLTRTLYLCRLRNRPMTYAMEEMRRLMLAFIAEQVRSGGWQAELVG
The following text describes a protein:
Function:
Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with alpha tubulin to the manchette of developing spermatids. Detected to nuclear rim in pachytene spermatocytes. Detected at nuclear surface, opposite the acrosome in elongating spermatids. Detected at the microtubule-organizing center (MTOC). Localized to the centrosomal region of late-stage spermatids (By similarity).
Sequence:
MVRLTLDLIARNSNLKPRKEETISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKYRDRLILVSKSLEFLDGKEIKNIERQFLMNWKASKDAKKISKKRSSKNEDASNSLISNFKTMHHIVPVYYPQVGKPKLAFFSEIQRYPVNANASPESS
The following text describes a protein:
Function:
Protein required for the cotranslational protein quality control in the inner membrane of the mitochondria. Associates with newly synthesized polypeptides and may act as a chaperone that cooperates with OXA1L for the insertion of newly synthesized mitochondrial proteins into the inner membrane. Required for the assembly of the ND4 module of mitochondrial complex I.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MENHKSNTKENITTVDISRKINQLPEAERNLLENGSVYVGLNAALCGLIANSLFRRILNVTEARIAAGLPMAGIPFLTTDLTYRCFVSFPLNTGDLDCETCTITRSGLTGLVIGGLYPVFLAIPVNGGLAARYQSALLPHKGNILSYWIRTSKPVFRKMLFPILLQTMFSAYLGSEQYKLLIKALQLSEPGKEIH
The following text describes a protein:
Function:
Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSGPDHVQCPVCAKTVTMNDINPHLDSHYSDSSGPSKPVSPFFKKERYKHHLETNVSSHQSATKFIEPEPSPTKKTKLTRRDTRPLAERARPKSLDEYVGQEELVGERGIIRNLIEQDRCNSMILWGSAGTGKTTLARLIAVTTKSRFIEISATSTTVADCRKIFEDSQNYLTLTGRKTIIFLDEVHRFNRAQQDIFLPMVEKGLVTLIGATTENPSFRLNSALISRCPVFVLKKLTRDNVKKILNHACLLESERLGSSMPNVETSIIDYISAITDGDARMALNALEMSIGMLRQGPLSLEDIKDKLVRSSALYDRVGDVHYDTISAFHKSVRGSDVDATLYYLGRMLESGEDPLYVARRMVRIASEDIGIADNSMLPLASSTFTAVQQVGMPEADVILAHCAVALALAPKSVDVYRSYNAVKSFLSSHPDAGRAEIPMHIRNAPTNLMKQLGYHKGYKYNPDYKDGLVMQEYLPDSIKGTKFYKLPIELKEDEEIKNLKTDTK
The following text describes a protein:
Function:
Probable transcription factor involved in the control of specification of mesoderm and endoderm. Acts in parallel with bonnie and clyde, faust and casanova in the Nodal signaling pathway.
Subcellular Localization:
Nucleus.
Sequence:
MALFYDQSFDLGLVQKINMETESDFIFNTNMLQFTDVTTKHMLSSPELDRTGHVEGQRKRKRTIFSRAQLSELERAFMITPYPDITLRERLAALTLLPESKIQVWFQNRRARSMKSKKLITPVSRRSPAKDCTFPATHPDLNLEQSPEANKSLRHHQQSLIRQALNPWPQNRPPISPDLPEILQWANRNSETPGDSSFSSCPSERIQHPFPNQSSSVWQMNCFAAHPEGLKSYCTTSQALYSSVSVDQMIPAHPSSLEEALQRQALTHYPQTSLGDISDLIYKAAVVTNLEEC
The following text describes a protein:
Function:
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable).
Subcellular Localization:
Nucleus.
Sequence:
MASPDRSKRKILKAKKTMPLSCRKQVEMLNKSRNVEALKTAIGSNVPSGNQSFSPSVITRTTEITKCSPSENGASSLDSNKNSISEKSKVFSQNCIKPVEEIVHSETKLEQVVCSYQKPSRTTESPSRVFTEEAKDSLNTSENDSEHQTNVTRSLFEHEGACSLKSSCCPPSVLSGVVQMPESTVTSTVGDKKTDQMVFHLETNSNSESHDKRQSDNILCSEDSGFVPVEKTPNLVNSVTSNNCADDILKTDECSRTSISNCESADSTWQSSLDTNNNSHYQKKRMFSENEENVKRMKTSEQINENICVSLERQTAFLEQVRHLIQQEIYSINYELFDKKLKELNQRIGKTECRNKHEGIADKLLAKIAKLQRRIKTVLLFQRNCLKPNMLSSNGASKVANSEAMILDKNLESVNSPIEKSSVNYEPSNPSEKGSKKINLSSDQNKSVSESNNDDVMLISVESPNLTTPITSNPTDTRKITSGNSSNSPNAEVMAVQKKLDSIIDLTKEGLSNCNTESPVSPLESHSKAASNSKETTPLAQNAVQVPESFEHLPPLPEPPAPLPELVDKTRDTLPPQKPELKVKRVFRPNGIALTWNITKINPKCAPVESYHLFLCHENSNNKLIWKKIGEIKALPLPMACTLSQFLASNRYYFTVQSKDIFGRYGPFCDIKSIPGFSENLT
The following text describes a protein:
Function:
GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MALYKLGLWASLWATFHTAAAKLDLNSQTNIAIYWGMLYLYQYVVHPPVSPHSNDCPIIVRVFQLAFVTRINGANGLPEVNFANAGDNCTTFEGTNLLSCPQIEEDIPICQSLGKTILLSIGGATYTEGGFTSESAAIAGANSVWQTFGPPSNNPSTLRPFGKAAVDGFDLDFESPVANMPAFANQLRSLFSSDPSKQYYLTAAPQCPYPDAADGPMLDGAVSFDAIWVQFYNNYCGLQAYNPGSTSQNNFNFATWDTWAKSVSRNKNVKVFLGVPGSSTAAGSGYVSVEALAQIIAYTKGFSSFGGVMAWDVSQVMANSGFLAGVRAALGSGSGSGSGSTTVSPTTASTTTSTSTPTTTTSSTTSAPTTSTSVTTTSTTSSTTAPTGSCPTAGARCSGGGAACNGASFGLCDNGVWVMQPCPGGLVCIQGGAGVYCGYPADKPAGSC
The following text describes a protein:
Function:
May have a role in cell growth.
Miscellaneous:
MISCELLANEOUS: A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGQSGRSRHQKRARAQAQLRNLEAYAANPHSFVFTRGCTGRNIRQLSLDVRRVMEPLTASRLQVRKKNSLKDCVAVAGPLGVTHFLILSKTETNVYFKLMRLPGGPTLTFQVKKYSLVRDVVSSLRRHRMHEQQFAHPPLLVLNSFGPHGMHVKLMATMFQNLFPSINVHKVNLNTIKRCLLIDYNPDSQELDFRHYSIKVVPVGASRGMKKLLQEKFPNMSRLQDISELLATGAGLSESEAEPDGDHNITELPQAVAGRGNMRAQQSAVRLTEIGPRMTLQLIKVQEGVGEGKVMFHSFVSKTEEELQAILEAKEKKLRLKAQRQAQQAQNVQRKQEQREAHRKKSLEGMKKARVGGSDEEASGIPSRTASLELGEDDDEQEDDDIEYFCQAVGEAPSEDLFPEAKQKRLAKSPGRKRKRWEMDRGRGRLCDQKFPKTKDKSQGAQARRGPRGASRDGGRGRGRGRPGKRVA
The following text describes a protein:
Function:
May act as a component of a corepressor complex that represses transcription.
Subcellular Localization:
Nucleus.
Sequence:
MPSVMEKPSAGSGILSRSRASMIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDELEEGRGGVSEGEPDPGDPKREPLPSRPLNARPGPGKKEVQVSQYRHHPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDGAPGAPVPMEEARRGAPLPAPALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPPLIRPALAAPRHSARPGPQPPPTLIGAPLEPPAPSL
The following text describes a protein:
Function:
Sodium-phosphate symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEDLLWTVIVGFVIAFILAFAVGANDVANSIGTSVGAKVLTLRQACVLASVFELLGAILVGAKVSDTIRKGIVDVNVYNGTEELLMFGNVAALSGSGVWLLVATFARLPVSTTHSIVGATVGFTLVAAGAKGVNWVQVALIVSSWVISPVLSGLITSAFFKFVEFFILKKDQAAQIGLKFLPGFYTFTIIINLFSIFYTGAPLLGFDKIPLYGVFILSFGGGLLTGLLVWLFLVPWMRRKIQEIHEAKLSQVPSQCMWRQSIEHLSKLPNTKLANSVILSKYEVQEDKAHCNMAFEETERGGNLRDAPQSNGVNMAYEETEGEENFRNAPQANGVISIVSQNGTTCPTDISSNTKETSSANGHTCYGAVLSTAPEEGTANSSLPSKDVEKLEDHEDVNTHVNIREAQDTPEVGKLFQFLQVLTAGFGAFAHGGNDVSNAIGPVVALWLIYQDGNVAQKSATPIWILFYGGAGLIIGLWVLGRRVIKTVGEDLTPITPSSGFTIEIGAATTVLIASNIGIPISTTHCKVGSIVFVGWLRSRTSVDWKLFRNIVFAWVVTLPVAGGISAAVMALLRLAL
The following text describes a protein:
Function:
May be involved in membrane protein folding.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion.
Sequence:
MQHKDTAVAKDTAKKRLLRRNSAPSAIHIISRLDKKWSFLWNTIDRHNIVEEQDESSAAKSEEEHEDDYELEQLLNMIRIPMFLEKFMLFALLTSLDCFLYYFTVLPIRLIKGYVKQFKSYRQHYRLQQRSGHKNKIPFRYRITSREYKERCMIFIIVISSILLSKLDTSKLYHRIKRQSTMKLYMLFSVLEMADKMLASLGQSLLTVMLSRKNSERILLHKCLLVSMSLTYVTIHGYVLVYQAISLNIAVNSYSNALLTLLLSMQFAEIKSSVLKKFDKEGFFQITIADVVERFKLTLLLSITGLRNLQSWSSSLSNTSINFWSPRSTLSIVINILCGPMVSVVGSEVLVDWAKHAYITKFNRIRPQIYDKFYYIIYKDYSTRTHKLEDRLGLPLPAFVVLFIVMVRPTLFKSSEPSYLPSLFRILFMGASVFLLALLAKFTLDLILIKWSKRIEQRFRDQAFNTVVTEEEYVPGLLSGGMGKVDVSTRIALHSDYNKENRIETESVSPMRKRKTTLTAECTPPSLNDIRRQKDSKNPRSLENVARYKMVSKRIW
The following text describes a protein:
Function:
Receptor that may have an important role in cell/cell signaling during nervous system formation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRGRVARAPLLLLLPPRLLLLLLLLLLSLGPGSFALAPSPCRSLEALDLSSPHLCIPQHWFCPAGNEGHWLHTSRCRARGPELTSRLVPLERFRGRRAWCPEPGAHIPLPPAPRGCPWSCRLLGARGHISPQGKLTLPPGHQCIQVPQLQCQLCRVAWAQGHWVEKWMAGDLPGSRRKRNVNTAPQFQSPVYQATVPENQPVGTPVASLRAVDPDEGEAGRLEYTMDALFDSRSNQFFSLNPATGAVTTAEELDRETKSTHVFRVTAQDHGTPRRSALATLTITVTDTNDHNPVFEQSEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLVEGPGGSPPEVFEIDPRSGVIRTRGPVDRETVESYQLTVEASDQGRDPGPRSATAAVCLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTATDRDKGSNALVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETAKEYTLRIRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGPDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPPLTASASVSVTILDVNDNNPTFTQPEYAVRLNEDAAVGTSVVTVSAVDRDAHSVITYQIASGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQVVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDGDTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSIYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYILRAFAVDKGVPPARTPVEVMVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYETRAEYILVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDVSDTLSYSFERGNELSLVLLNASTGELRLSKALDNNRPLEAIMSVSVTDGAHSVSAQCVLRVTIITDEMLTHSITLRLQDMSPERFLSPLLGLFIRGVAATLATPPDHVVVFNVQRDTDAPGAHILNVSLSVGRPPGPGGGPPFVPSEDLQERLYLNRSLLAAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASASVLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCREGFTGEHCEVSARSGRCAPGVCKNGGTCVNLLVGGFKCDCPSGDYEKPYCQVTTRSFPARSFLTLRGLRQPRLCGPEVIQEQVQLTFSAGESTTTVSPFIPGGVSDGQWHTVQLQYYNKPLLGRSGLPQGPSELKVAVVTVDDCDPGVALRFGAVLGNYSCAAQGTQAGSKKSLDLTGPLLLGGVPDLPESFPIRTRHFVGCMRNLQVDSRRVDMADFIANNGTVPGCPAKKNVCDSNTCHNGGTCVNQWDTFSCECPLGYGGKSCAQEMANPQRFLGRSLMAWHGLALPITQSWHLSLMFRTRQADGVLLQGITRGHSTITLQMTEGHVMLSVEGTGVQTSSLRLEPGRANDGDWHHVQLVLGVSGGAREPGHAVLSFDYGRQQAEGNLGPRLHGLHLTNVTVGAVAGPGGTVAQGFRGCMQGVRVGEAADGASSLDPSRAERANVEQGCSLPDPCDSSPCPPNSYCSDDWDSYSCSCDPGYYGDSCANVCTLNPCEHQSVCTRKPSAPHGYTCECPHNYFGPYCETRIDQPCPRGWWGHPMCGPCNCDVSQGFDPDCNKTSGECRCKENHYRPLGSPACLLCDCYPTGSLSRVCDPEDGQCPCKPGVIGRQCDRCDNPFAEVTANGCEVNYDSCPRAIEAGIWWPRTRFGLPAAAPCPKGSFGTAVRHCDEHRGWLPPDLFNCTSVTFSELKGFAERLQRNESGLDAGRSQRLAVLLRNATQHTAGYFGSDVKVAYQLATKLLAHESVQRGFGLAATQDVHFTENLLRVGSSLLDVGNKRHWELIQQTEGGTAWLLHHYEAYASALAQNMRHTYLSPFTIITPNIVISVVRLDKGNFAGAKLPHYEALRGERPPDLETTVILPESVFKPTESQGGPVVPGEAREQEELGRRQRRHPELSQGQAVASVIIYRTLAGLLPHNYDPDKRSLRVPKRPVINTPVVSISVHDDEDQLPRALDKPVTVQFRLLETEERSKPICVFWNHSILVSGTGGWSARGCEVVFRNESHVSCQCNHMTSFAVLMDVSRRENGEILPLKTVTYAALGVTLAALLLTFLFLASLRALRSNQHGIRRNLVAALGLAQLVFLLGINQADLPFACTVIAILLHFLYLCAFSWALLEALHLYRALTEVRDVNTGPMRFYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLIWSFAGPVAFAVSMSVFLYLLAARASCAAQRQGFEKKGTGTRPGLGPQGLRSAFVVLLLLSATWLLALLSVNSDALLFHHLFAACNCVQGPFIFLSYVVLSREVRKALRFACSHKPSPDPALTTKSTLTSSYNCPSPYVDGRLYQPYGDSAGSLHSASRSAKSQPSYIPFLLREESSLNTGQGPTGLGDPGVLFLEAQDPQHGPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEDGAFPGEPGWDSLLGPGAERLPLHSTPKADSGPGPGKAPWPSDFVAATKENGGGGPEERFRENGDAVSRDGPLGPLPGCPPTAQPHKGKSGPSILKKKCLPTISEKSHLLRLPPEPGTGSSRGSSASEGSRAGPLPPRPPPRQTLQEQLNGVTPIAMSIKAGTVDEDSSGSEFLFFNFLH
The following text describes a protein:
Function:
Multifunctional protein that acts as a viral transcriptional activator. Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription. Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA. Clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures. Also assists stop-start transcription at gene junctions to promote transcription of downstream genes. Interaction with NP plays a critical role in transcription initiation by recognizing the RNA stem loop (By similarity). Interaction with host RBBP6 interferes with NP-VP30 interaction and inhibits viral RNA synthesis. Also acts as a suppressor of RNA silencing by interacting with host DICER1 and TARBP2/TRBP.
Subcellular Localization:
Virion. Host cytoplasm. Note=Present in viral inclusion bodies due to its interaction with NP.
Sequence:
MEASYERGRPRAARQHSRDGHDHHVRARSSSRENYRGEYRQSRSASQVRVPTVFHKKRVEPLTVPPAPKDICPTLKKGFLCDSSFCKKDHQLESLTDRELLLLIARKTCGSVEQQLNITAPKDSRLANPTADDFQQEEGPKITLLTLIKTAEHWARQDIRTIEDSKLRALLTLCAVMTRKFSKSQLSLLCETHLRREGLGQDQAEPVLEVYQRLHSDKGGSFEAALWQQWDRQSLIMFITAFLNIALQLPCESSAVVVSGLRTLVPQSDNEEASTNPGTCSWSDEGTP
The following text describes a protein:
Function:
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
Sequence:
MYNKVIMIGRLTSTPELHKTNNDKSVARATIAVNRRYKDQNGEREADFVNMVLWGRLAETLASYATKGSLISVDGELRTRRFEKNGQMNYVTEVLVTGFQLLESRAQRAMRENNAGQDLADLVLEEEELPF
The following text describes a protein:
Function:
Serine protease which plays an essential role in the shedding of AMA1, MSP1 and MSP7 from the surface of the invading merozoite; this step is essential for productive invasion and the release of the adhesion between the erythrocyte and the merozoite. May cleave TRAMP/PTTRAMP, thereby shedding TRAMP from the merozoite surface during erythrocyte invasion.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, microneme membrane; Single-pass type I membrane protein. Note=In mature schizonts, localizes to micronemes at the merozoite apical region. Immediately after schizont rupture, secreted from the micronemes to the merozoite surface where it redistributes in an actin-dependent manner to accumulate at the posterior end of newly released merozoites.
Domain:
The propeptide domain acts as an intramolecular chaperone for the folding of the catalytic domain (By similarity). Also acts as an inhibitor of the catalytic domain thereby regulating SUB2 activity during secretion; The transmembrane domain is required for SUB2 progression through the secretory pathway; The cytoplasmic domain is required for the correct redistribution at the merozoite surface and posterior capping but is dispensable for its progression through the secretory pathway.
Sequence:
MLNIIYVVSLILIKFIFYKECNNNNNYYLSNIELYNYKLRKRNRILNNNINDRKSFLSDLEQNYKPLFDIYELSANFEKRRKELEKKTKGEENEIEKKKENDLEKKKENEIEKKKENDLEKEYNDVINLLELSLSSEYKELNADVSNNDNSGHEENNKHKLNKKNSSNYKNDKSLDELIKGAILKLKQNPNIKNKNMLDYDKIFKIIKEKLINKNLASNKIKGGDNEKLKEEKKQSDISTNVEVKKDIINDQLNKGIPTKKENKDDMINKESNKEDITNEGKSNSLNNLNTLNNDGNIITKVYDHYTIVTNSNDILNDISIDASDISKNSIGGINIPFNENDNSSFTHQRYIVLSNNGEKKYKIVLMTKNPKFMDMDGIYDEEEKKESLIELNQKVNKEENTNLYDGTGTLYYGKKSKKEKENTQQKGGNNPNVDINILNNNNNNNNNNNSNNNSNSMNDEEINYNNNNNNKESPSMFRRFINFLSFSGNENETEDTLIYHNKNDNSYKNKKEGTGKNNDNNDPNNNNNKKILLNVDKLVDQYLLNLKNNHTSKQELILVLKGELDLHSKNMKNVINNAKKNLEKYFKEHFKEFDKISYDISTPINFLCIFIPTLFDMNNMDLLKQALLILHNDLHEYVENWSFSSTYHTYEADYIKEQDSVYDRSPKKKYIKASKKLYNNKYSFLNKFLNIEPLILFAKKLNSKRSNIEKEILNFLPKELRDYSTWNLSIIRVFNAWFLAGYGNKNVKVCVVDSGADINHVDLNGNLYIPEYNEKYEMTQDFYNFMVKNPTDASGHGTHVTGIIGGVANDLGVVGVAPNITLISLRFIDGKKYGGSFHAIKALNVCILNKAPIINASWGSSHFDVNLHLAVERLKYTLNGKGSVLIAASGNKSNDNDISPLYPATFTFPHVYSVASISRNFEISPFSNYGHKSVHILAPGHHIYSTIPNNSYKIFTGTSMAAPHVCGVSALVYSVCYNQGFIPQAEEVLDILTRTSIKIISTKKRTINDSLVNAEGAVLTTLLGGLWMQMDCYFVKFNLEKGKKKHIPVVFSAYKKGVYETDIVIAIIPIDGKSKIYGEIHIPIKIVTDVNIPNFQESPRRGKNYTIDSNEAQHDEVLSYICENALYNLYEYDSHYLLASVILFFLALLSIFVGMIYMKSRKHSDKKCSKNLIKSNYIPEMDDGMEETQQLQQERRQYFRELFGENLEKNYDQHFVQDFGQDFRQDFKLGSTPDLKQYSDIDLQNKIQQPERKTVKIIINNFEDRKKETKRRLLKGLNYDGENAKKHDFTNESISNSRKNFKFSNNTEMKKNTIKSEDVKIASDDNVNKAMNQLDDMFMK
The following text describes a protein:
Function:
Essential for sperm motility and male fertility (By similarity). Plays an important role in sperm motility by regulating the organization and function of the mitochondria and is also required for correct sperm midpiece assembly (By similarity).
Subcellular Localization:
Mitochondrion outer membrane. Mitochondrion. Cell projection, cilium, flagellum. Note=Localizes to the midpiece of the sperm flagellum.
Sequence:
MIITTWIVYILARKGAGLPFPPKVSSDVEVTETEAVSVVQHWLKKTEEEASQEIKEKMSTNFPPMQGQDVHVTRDVVKHHLSKSGLLANQSQEVLEERTRIQFIRWSHTRIFQVPSEARNEAMRDRIEQVRRSICHLSDEISQELRNRNSYSEC
The following text describes a protein:
Function:
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress; Leumorphin has a typical opioid activity and may have anti-apoptotic effect.
Subcellular Localization:
Secreted.
Sequence:
MGGSRKSQDRMVWQGLVLAACLLALPSVTADCLAQCSLCAVKTQDGPQPINPLVCSLECQAALQPAQEWERCQGLLSFLTPFTVRLNGKEDLKSKTVLEESSSEPAKHIRPYLKELEKNRFLLNTPAEKNALSSSLAEKLRGLSGRLGEDAESELMGDAQLNDGALEAEARDSNEEEPKEQVKRYGGFLRKYPKRSSEVTGKEAGEGEGGEVGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPSAYYEELFDV