lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.
Sequence:
MNSTDASADDTLDLHLPEEFVALFRSPAHDAAEAGTARAREDLLDGIADWGPSDTPAGVFHLVPADLERDVPLIARWMNDPAVAAYWELTGPQSVTADHLRAQLAGDGRSVPCVGTLDGVPMSYWEIYRADLDPLARYCPVRPHDTGVHLLIGDGAHRGRGLGTELIRAVVDLVLAGRPACTRVLAEPDVRNRQSVAAFLGAGFRPTGEVDLPTKRAVLMIRAREAREQSP
The following text describes a protein:
Function:
Involved in regulation of microtubule dynamics. Regulates the interaction of microtubules tips with the centrosome and cell cortex.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules.
Sequence:
MGDEEAPSGSIEDRINHKNWKWRVSGLEELTTKFRNSIEGSGPLFNEWGPQFKKILADINPMSQERALEPLSAFIDRCDCVNKFAASYVGVLVEKLFASTRPRAKEKTIECLLLTIEADSAEPVVEALLKGTSSTSPKILLASLAALTQALKTFGPKQIPVKLILKQFSPWFENRDKGIRDQASELFIEIYRWIGKALIPLISEALTPIQLKALQDQFEKLPTDPAVPLKYTRSEAAKALANASKGIQAKPEVVEEIDPYSLMTAVNILPKLTSEFYEGLQAKKWQERSEQMDKLVTILTNTPKIETADFSELCKALKKILADVNVMIVQKAVVSIGLLADSLRGGFTSYVKPFITPILEKFKEKKTSVLQSVHTTMDSLVGKSISLSDIIDELTATMQSKVPQIKQEVLVFICNSITNTKKPADITKVTKQLTKIFMEALNDTDSNIRDNASKAFAALGGIIGERAMTPYLNQIDPIKAKKIKDNMPAVATPVTITPQPLAPVDLKDIDLPVSSSNKKPAAATGNSKSSSTTTPTGRSSNSSPLPPPPSSSDDIKNKLIGAGIVNNEIIEGLGKTQWKDRLQAVDDILENVKGLTADSINGMSESIIQLLCDKPSLKESNFQVLSSIFSIFIQCCKNDSNFTQQRCANSYLTTCIEKLTDVKLKEISSELLFSTGESITPHAVFTSIYQFTSNHKNPKIIADSLVWIQQAIDEFGIGCCSNGIQQLKPLLDYTKQCLESTNPDVKKSAIKLLCTIKINIGATLTDFLGDVKKPTMEVLDREFQKIRDQKPPVPNRQWKGMPPPGSAPVQIEFPRVDISVKLTPAIITNLSDANWKTRSDALDEIERIIIDANRKIQPKLGGLIPALKNRLTDNNQKCTITTLNIIGMLSQAMGGQSFEKHARLLIPGILLLLGDSKKPVRDAVISCMNVIVQSDLGFDVFIGSLAAPMIQESAFTRKESLAWTIVNVTNMKAAPIPSEINTLAKGIISCLQDKSAEIRSLADNLLSILCTQIPLIEFKKELKHVKPASQPSIQTILDKYYQKTGQPIPPPSKTKQSTSSSSSSSSTTSQQSSTPSSPQPIRQQQQQQQQQPTQPQQQQQQQQRRSILQSNNGASNCEFIIFDINGKMNRQKTNQIPSWHFIEPTEEVVEILQDQVLQCFTEEFANLMFSSLPSNSQHMSDLMIGMIEQNPEAIISVLDILFRWITFKLFDTGLASQKRVLKILEILLNKLIDSEYSIGEYEASCLVPILLEKSGSATNEQIKQIFKQSIQQLEELCLPNVLFRFAIEMVTSQNWRTRVEVLNVMASIIDKNGASVCGNLKVVIPLITQNLNDSQSKQSSLLCLNKLYSHIKDECFKYSNISQQDKILIIGNNNNNNNNNNNNNNNNNNNNVQQQQQQQQQQQQQQPRKSLSTDEMSTQLIGCLELLKNYSITKENIEHTVEALKQFSGLMANGKLDDVFVNFAEEYFLVLTSILADTFPQVSKDATILRLCKYLIHTIISILSNKVVAKQCNVRCLEIVLNETIKLYSLAESNSSKQGTESELSKAFNQILLRILQNCNSTILFSTLLQMMSRTDNDQSIQHPGKYNDLLLRCLLRATKSLTTPSILEELNVETVLSEINSFLKSNPSLDEITRKTTKTLTSELYQNRTNQVVKFTKDIISKGQQQKYQYLLNLLIELVPKQFEDLINGNGNGNRISSGGSNNNNNNGGRVSSGGNNNNNSGRENINNININSSLDSPINDHHNSNNTTTTTTRSRTSTGSSNSQQQQLPTTSANTTTTTTTTTTTGKTQSTLSTLKINKEPRDYSGKTDSQKKELLIEIFKKIGNKDLTLDGIHDLYFFIREYPDYDITPNLNSSSQQFQAYITRNLKKIKDSMDAPKDKDDEVVNYQERLKVIQNTFYNQHNQPSSQVVNNNNNNNNNNNNNNNNNINNNNNNNNNSGGNENIAPQLSNTASMASNTLQRLRTLNPDQNSGSNNNNSHQNSPSTSSSNDLNSTVASLRQRLAQLTSKSNE
The following text describes a protein:
Function:
Acts as a hyperosmolarity-gated non-selective cation channel that permeates Ca(2+) ions. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ions: activated in response to membrane stretch. Not activated in response to membrane poke.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEFGSFLVSLGTSFVIFVILMLLFTWLSRKSGNAPIYYPNRILKGLEPWEGTSLTRNPFAWMREALTSSEQDVVNLSGVDTAVHFVFLSTVLGIFACSSLLLLPTLLPLAATDNNIKNTKNATDTTSKGTFSQLDNLSMANITKKSSRLWAFLGAVYWISLVTYFFLWKAYKHVSSLRAQALMSADVKPEQFAILVRDMPAPPDGQTQKEFIDSYFREIYPETFYRSLVATENSKVNKIWEKLEGYKKKLARAEAILAATNNRPTNKTGFCGLVGKQVDSIEYYTELINESVAKLETEQKAVLAEKQQTAAVVFFTTRVAAASAAQSLHCQMVDKWTVTEAPEPRQLLWQNLNIKLFSRIIRQYFIYFFVAVTILFYMIPIAFVSAITTLKNLQRIIPFIKPVVEITAIRTVLESFLPQIALIVFLAMLPKLLLFLSKAEGIPSQSHAIRAASGKYFYFSVFNVFIGVTLAGTLFNTVKDIAKNPKLDMIINLLATSLPKSATFFLTYVALKFFIGYGLELSRIIPLIIFHLKKKYLCKTEAEVKEAWYPGDLSYATRVPGDMLILTITFCYSVIAPLILIFGITYFGLGWLVLRNQALKVYVPSYESYGRMWPHIHQRILAALFLFQVVMFGYLGAKTFFYTALVIPLIITSLIFGYVCRQKFYGGFEHTALEVACRELKQSPDLEEIFRAYIPHSLSSHKPEEHEFKGAMSRYQDFNAIAGV
The following text describes a protein:
Function:
Galactosyltransferase involved in the biosynthesis of the core oligosaccharide region of lipopolysaccharide (LPS). Catalyzes the addition of galactose from UDP-galactose to the first glucose residue of the LPS outer core. Cannot use other sugar donors, such as UDP-glucose, UDP-glucuronic acid, UDP-galacuronic acid, GDP-mannose, ADP-glucose and GDP-glucose. In the absence of a lipid acceptor, can hydrolyze UDP-galactose to UDP and galactose.
Sequence:
MKIAFIGEAVSGFGGMETVIRDVITTFRQQHIQSEMFFFCRNDKMDKGWLEGIKYSCSFSNIRLGFLRRAKHIHALSKWLQEYQPDIVICIDVISCLFAAKARKKSGIDMPVFSWPHFSLDHKKHAEYITCADYHLAISSGIKQQMINRGVAESTINVIFNPVETKDSVIPAPEEGETATFIYVGRMKFEGQKRVKDLLDGLSQAKGNWKLHVLGDGSDFEKCQAYGRELNIDDRIVWYGWQQYPWELVQQDIEKVSALLLTSSFEGFPMTLLEALSWGIPCISADCVSGPADIIQPDVNGHLYQPGDIAGFVTLLNKYIAGEIHIEHEKIPASIDEFYQSKYYDRLHKVIISAISRRK
The following text describes a protein:
Function:
Initiates complement activation and/or interferes in platelet aggregation and/or blood coagulation.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MLRLPRLQGSILRTLTTQPFNAKASPSAQGSILRPLTTQPFNAKASPSAQGSILRTLTTQPFNAKLGGQNRANKRLSLCADPDFPVLTLRRLVFPQVFQRREDGSVNFFRGWEAYRDGFGKLTGEHWLGLKRINALTTQAAYELRIDLEDFENETAYAHYGTFSVGLFSVDPEEDGYPITIADYSGTAGDSFLKHNGMRFTTKDLDNDHSDNNCATFYHGAWWYRNCHTSNLNGQYLKGQHSSYADGVEWSSWTGWQYSLKFTEMKIRPAREEN
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSPLTYTFIAGSSMDSWPSLQSSVMSALKEEEKHLPQPKPPAKPVENPITLTIQGQRTVQEIADKAIELFRKLQNARLSTDTTSRQSQAQTKDIRDQLNTLKGLLAKLRNVYNDTKRAVTIPAGENVENLIPLECSPRNEMDTSDGGGPVEQERAELQKKLKEKNDQLKEVIDKLRIAVWDINTMIMLKPS
The following text describes a protein:
Function:
Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (By similarity). Required for efficient export of polyadenylated RNA (By similarity). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B (By similarity). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (By similarity). Regulates transcriptional elongation of a subset of genes (By similarity). Involved in genome stability by preventing co-transcriptional R-loop formation (By similarity). May play a role in hair cell formation, hence may be involved in hearing (By similarity); Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1. Essential for early embryonic development. Required for normal gene expression during postnatal testis development (By similarity). May play a role in hair cell formation, hence may be involved in hearing (By similarity).
Subcellular Localization:
Nucleus. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm, cytosol. Note=Predominantly localized in the nucleus (By similarity). Shuttles between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution (By similarity).
Domain:
An intact death domain is needed for apoptosis.
Sequence:
MEYYSAIKNNDIMKFLSKWMGVEEIIPKAGKEPDVLQQTMDTENVVYLHNGLLLSYNDFMKFIGKWMELEYIILSEFCEERASYTKLKRGVWKRSAPEDFLDKRPNKKILIGNEELTRLWNLCPDNMEACKLETREYMPILEEFFEEAIEQADAENMVESEYKAINNSNYGWSTLRFLAWRSPHFFQPTNQQFKNMTEYLENMVIKLAKELPPHSEEIKTGEDEDEEDNDALLKENESPDVRQDKPITGERIESLTNKLDEQWKILAPYLEIKDSDIRQIECYSEDMKKRAKQLLVAWKDQEGVHETTDNLIGALNKSGLSDLAESLTNDTETNSYLLSLLFY
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLGAALRRCAVAATTRAGPRGLLHSARTPGPAAAIQSVRCYSHGSQETDEEFDARWVTYFNKPDIDAWELRKGINTLVTYDMVPEPKIIDAALRACRRLNEFASTVRILEAVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKV
The following text describes a protein:
Function:
Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.
Subcellular Localization:
Nucleus.
Sequence:
MSLYDGLGVDTGPSKKDSSAGDKKGDVSGWSAGIKMMQSHLRMKKAALTEAQRKMKQPSGRPVLDPKKVPAPGLGSSTAPASSSRSSGDVSGRDVGGRDVGGRDAGGRDVGGRDIGGRDVGGSTGLLDDHPRFRPSNLPPPSRPSSSSSPRLAPYLPSSSLGSDGENEYDPAYPNEYEKVAKKLREKRERERDEQDKREREERRRRREKDRERDREKDRDRDRERRDRDRDRERDREREPQGFSRRPVMEDDEDDRDRERRRNTAQRAAIAPPSSLINEDSQSKDDGFAAPLPPARDRPYADMKRKNHDHDDLEGAKTPPRISEFAPPQEQNTFVKPPTPKANFQVPVGLGVDSVAMKIMAKYGFKEGAGLGKSEQGISTALQVEKTSRRGGKIINKDKEIQEQVVMPPPPMPPPAFPPPAFPPAAPKTGPAPITDVLRNPTKILLLTNMVGPGEVDDDLQPETAEECSKYGEVVKVLIYEDPLKVATEAVRIFVEFTRVEAAVKAVVDLNGRFFGGRIVKGSFYDPQKFGKFELTA
The following text describes a protein:
Function:
Self-assembles to form a helical, filamentous nucleocapsid (Probable). Together with capsid protein 1, wraps arounds the DNA and maintains it in an A-form (Probable). Capsid proteins probably maintain the DNA in A-form by non-specific desolvation and specific coordination of the DNA phosphate groups by positively charged residues (Probable). This certainly protects the viral DNA under conditions such as the extreme desiccation of its host (Probable).
Subcellular Localization:
Virion.
Domain:
The N-terminus projects into a DNA groove.
Sequence:
MARKRTSKNDPLRMYLNYVRKLQTMGDAYDESAKYRIANFENGFKSLHMVENEFKQYLANVIDEAIKSGASPQDLPYVNEIKLALMKIFTSWLKYSNEKLGANEIAINVAGTATMTLTENLYGTRVSCEEAVSLINSIFAVWVGVEPFEAEEREGACLVTPRSPLPPVPISSPTGFSAPIQEVLQAKSPEEIIGVKGGA
The following text describes a protein:
Function:
Has a lower Ca(2+) affinity than isoform 1.
Subcellular Localization:
Cytoplasmic vesicle membrane. Endoplasmic reticulum membrane; Peripheral membrane protein. Endosome. Nucleus.
Sequence:
MAYNHDGMPDQQFLWDVFQRVDKDRSGHISADELQVALSNGTWSAFNPETIRLMIGMFDRENKGTVSFKDFGALWKYVTDWQNCFRSFDRDNSGNIDKTELKTALTSFGYRLSDHLIDVLLRKFDRFGRGTILFDDFIQCCIVLYTLTTAFRQHDTDLDGIITIHYEQFLSMVFSLKI
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MNINSIWLNFISLFLTYLPQMKCFYYVKNKANRENAVTYAFTSSIMMHAFMKECIGKRLECTCDTKPVGPKSNVTSWKALCVSHYTYSINLTKLILDKSFENSKDSRALMNHHNLRAGRIAVKRTLYNECTCHGTSGSCQFKTCWQRVASPLSIGNEIYKQYKDARLVQVVKDQLIRKKSTAKLDNAEKESKPVSAGKLVYLERSPNYCNATMPDGSILTTIGRNCTRQGESFKSCSQLCLKCGYKVKSVTVPKTVRCNCIYNLFLKNTVNCELCLKNVTHNWCIPSSFV
The following text describes a protein:
Function:
Could act as a modulator of glutaredoxin biological activity. May play a role in cytoskeleton organization.
Subcellular Localization:
Cell projection, ruffle membrane. Cytoplasm, cytosol. Nucleus.
Sequence:
VERKCGENLLSGAVPVLVCLLSRGVSHVWVSPEGVGRGSVERGSLAWELQVWKQHKPSKPSCATCSRGSEVGSGVQQTRARLRSRLLPNLRPCPPGLSRHGVSRQPQTVSPRSGEGRRGRYCEGLGSWARPAPEREGGRRRAGRGRSSHAPAARLPAPPIGPESSDSRAEQEGNRSRARRRRLQAVELPLPPPVRLSARPSTRSMSGLRVYSTSVTGSREIKSQQSEVTRILDGKRIQYQLVDISQDNALRDEMRALAGNPKATPPQIVNGDQYCGDYELFVEAVEQNTLQEFLKLA
The following text describes a protein:
Function:
VirG is required for the positive regulation of at least two vir loci encoded by the Ti plasmid of A.tumefaciens.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGQDPRLRGEPLKHVLVIDDDVAMRHLIVEYLTIHAFKVTAVADSKQFNRVLCSETVDVVVVDLNLGREDGLEIVRSLATKSDVPIIIISGARLEEADKVIALELGATDFIAKPFGTREFLARIRVALRVRPSVARTKDRRSFSFADWTLNLRRRRLISEEGSEVKLTAGEFNLLVAFLEKPRDVLSREQLLIASRVREEEVYDRSIDVLILRLRRKLEGDPTTPQLIKTARGAGYFFDADVDVSYGGVMAA
The following text describes a protein:
Function:
Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSGLQRRRVNNTASADETWGSSERQTSTVPKTDEDGPKIGYDPKDIRTAEEEEKQPRLTLMEEVLLMGLKDQQGYLSFWNDNISYALRGCIIMELALRGKVQMVNDTNRRRFPISDRYIEVINDKLTGEALLDETIKIMKASEKLTVGTWINYLSGETWNLSKISYQLKQVRERLSKGLVDKGILRTEKRNFFLFDMPTHPVADTGAKEDIKKRVLSLLTARTVVINPSPYLPEGVPFRYLRSVGAVCGAYAANVLENVLADLSYEMRDQAFARADDLLNDFSEWPFVEKPGQTQNVGVNLFQEINDEIAANPNKELQLEVVAGVFDIFANLDSIL
The following text describes a protein:
Function:
Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones.
Subcellular Localization:
Vacuole.
Sequence:
MKSFANVTLFLLQSFLFPLYSSSLHQTSPDNSSPFPSDFLFGTSSSAYQYEGAYLTDGKGLNNWDVFSHEKPGDILDGGNGDIAVDQYNRFMEDIQSMNYLGVNSYRFSISWSRVLPKGRLGGINHLGVEHYNRLIDALIRNGITPFVTLNHFDYPQELENRFKSWLSPEMQKEFGYLADTCFKHFGDRVKHWITINEPNQQIILSYLKGIFPPNRCSMPFGNCSQGNSETEPFIAAHNTILAHAKAVQIYQTKYKKEQKGSIGIVVQTSWFEPISDSTADKNAAERAQSFYSNWILDPVVYGKYPKEMDCLISACNSGDGASRSEGFALKLIQKGNISVGEVTDVSWLNIDPKGFRKMLNYLTDRYPNIPMFITENGLGELQKPETTVKELLNDTKRVRYLSGYLDALKTAMRDGANVKGYFAWSLLDNFEWLYGYKLRFGIYHVDYTTLKRTPKQSAYWYKNFIENHMRTRDLADKK
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Subcellular Localization:
Cytoplasm.
Sequence:
MNQTVYLYTDGACKGNPGAGGWGVLMRYGSHEKELFGGEAQTTNNRMELTAVIEGLKSLKRRCTVIICTDSQYVKNGMENWIHGWKRNGWKTASKQPVKNDDLWKELDALVGRHQVSWTWVKGHAGHAENERADDLANRGAAQFS
The following text describes a protein:
Function:
Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MSADRHYSPIDRFLLQADSALRTLLPFSGQPARPSPAIVEPDGELSEEDTRHIAGLMRINHTGEVCAQALYQGQSLTAKLPEVREAMEEAAEEEIDHLAWCEQRIRQLGSRPSVLNPIFYGLSFGVGAAAGLVSDRVSLGFVAATEDQVCKHLDEHLAQIPQEDRKSRAILEQMRIDEEQHSSNALAAGGLRFPAPVKLGMSLLAKVMTKSTYRI
The following text describes a protein:
Function:
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
Subcellular Localization:
Nucleus.
Sequence:
MCAFHAKFKEAALFKRVVESLKSTIDKTNFDCSDAGIAVQCMDNSHVSLVSLLIETDAFDEFQCLKPITLGINLTHLSKILKALDNDCGLILDVKKVDDAVLSITSEGTNKTMKFGLNLVDIEAESVEIPELQSDAIITLSSAEFLKITKDFSALGDDSITIGCTKNEVTLTTKGAMCETCMTLSALENVDSNGLQIEHNKDVTASFALKQISEFAKSAPLADNVKLSLSGQAPLIMEFKGEACVLKFYLAPKFDEEDEPQE
The following text describes a protein:
Function:
May play only a redundant role in maintaining cell wall viability and bacterial virulence.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRLSIVTTMYMSEPYVLEFYRRARAAADKITPDVEIIFVDDGSPDAALQQAVSLLDSDPCVRVIQLSRNFGHHKAMMTGLAHATGDLVFLIDSDLEEDPALLEPFYEKLISTGADVVFGCHARRPGGWLRNFGPKIHYRASALLCDPPLHENTLTVRLMTADYVRSLVQHQERELSIAGLWQITGFYQVPMSVNKAWKGTTTYTFRRKVATLVDNVTSFSNKPLVFIFYLGAAIFIISSSAAGYLIIDRIFFRALQAGWASVIVSIWMLGGVTIFCIGLVGIYVSKVFIETKQRPYTIIRRIYGSDLTTREPSSLKTAFPAAHLSNGKRVTSEPEGLATGNR
The following text describes a protein:
Function:
Functions as part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit that coordinates the first two steps of ribosome biogenesis in transcription of the primary transcript pre-RNA and pre-18S processing. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Has a role in bud site selection maybe via the regulation of expression of bipolar budding components.
Miscellaneous:
MISCELLANEOUS: Present with 2120 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSNGHVKFDADESQASASAVTDRQDDVLVISKKDKEVHSSSDEESDDDDAPQEEGLHSGKSEVESQITQREEAIRLEQSQLRSKRRKQNELYAKQKKSVNETEVTDEVIAELPEELLKNIDQKDEGSTQYSSSRHVTFDKLDESDENEEALAKAIKTKKRKTLKNLRKDSVKRGKFRVQLLSTTQDSKTLPPKKESSIIRSKDRWLNRKALNKG
The following text describes a protein:
Function:
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.
Subcellular Localization:
Cytoplasm.
Sequence:
MENLSDVHLTDFIPSIYTTPCTLRYTQNGKPLERGIFAERNGVLIIVYNKTQNALTLVRQFRPSVYLSRIPQGDRVGTIDTGKYPASLGITLEFCAGLEDKTAPTEQIAREEILEECGYDVPLEKLEKIATFKNLTETTGARSTMYYCEVTDDMRVAQGGGVDDEIIDVVEMPVEEVLEYAQQGYVNSPMNFMFGLQWFLYHKYKRLGPV
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MGVKIDLGFLKQSGRKSLIIGISSHLIPTVLVVIFYIVWHVYLDFDTNNQIRFDLYRDTVLPWSLSSIVVVASLLDEMNLLNSKIGRMAIAASLMESILLIIYDVVGGIYFLGSLSWGPYRAFLPMISFVCFATLIGVVGRPVTQWMVKRTIEGAPLAEEYIGFILLMTLAFAFSSTIIGQGTSAGVFFLGLALPSGPPLGSTLVTKLEGIVDALFLPIFLATLGFLIDFSMLGEYLGMTLHFVLFDVVSFIGKILGVIGIASLCRVRFQNILILTLILNAKGITEVEGVFRWEDLQNKHISFITVRLFEILVVAVLVPPLLKILYKPSRRYYEPRRRSLLGANRKLELKILACVYNQDQVLPAVNIIESLCINDTYPLSISVLHLTQLVGRVSPVLVEYWKGMPSYGSTESDHIVATFSGFKETKMETMAGISIETYLSISNYSSMFDDICTLSMDEKMSMIFLPFHRTQMDETLIFANEHSREANNAVLQYATCSVAIIIDRGGIGNNLQTIHSRNNVFDKICVYFVGGADDREALALAMRMALNRSVSVTLVHFKPKSATASEEDPIIHFTEKMESERKVDEDNIQKFLAENRDRNTTEYLEMEVSDGEEMVGIIRKTVAKFNLVIVGRREGILKSEMMFGMSEWNEFPELGVFGDMLASMDFDCNISTLVVQQ
The following text describes a protein:
Function:
In vitro, opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is unknown.
Miscellaneous:
MISCELLANEOUS: Betalamic acid is the structural unit of the betalains, natural nitrogen-containing water-soluble pigments with high colorant and bioactive properties, characteristic of plants of the order Caryophyllales.
Subcellular Localization:
Cytoplasm.
Sequence:
MTPLVKDIIMSSTRMPALFLGHGSPMNVLEDNLYTRSWQKLGMTLPRPQAIVVVSAHWFTRGTGVTAMETPPTIHDFGGFPQALYDTHYPAPGSPALAQRLVELLAPIPVTLDKEAWGFDHGSWGVLIKMYPDADIPMVQLSIDSSKPAAWHFEMGRKLAALRDEGIMLVASGNVVHNLRTVKWHGDSSPYPWATSFNEYVKANLTWQGPVEQHPLVNYLDHEGGTLSNPTPEHYLPLLYVLGAWDGQEPITIPVEGIEMGSLSMLSVQIG
The following text describes a protein:
Function:
Probable ATP-binding RNA helicase.
Sequence:
MSSSVRRKGKPGKGGGKGSSRGGRGGRSHASKSHGSGGGGGGGGGGGGGGNRKASSRIWDDGDDFCIFSESRRPSRPSNSNISKGESRPKWKPKAKVPLQTLHMTSENQEKVKALLRDLQEQDADAGSERGISGEEEDDEPDCCNDERYWPAGQEPSLVPDLDPLEYAGLASVEPYVPEFTVSPFAVQKLSRYGFNIERCQAVLRMCDGDVGASLEHLLTQCFSETFGERMKISEAVNQISLDECMEQRQEEAFALKSICGEKFIERIQNRVWTIGLELEYLTSRFRKSKPKESTKNVQENSLEICKFYLKGNCKFGSKCKFKHEVPPNQIVGRVERSVDDSHLNANEDASFLYELEIRFSKDHKYPYQAPLVAFYSTNENLPLACRLHISEFLYDKALTFAETSEPVVYSLITLLEEESEIVKLLTNTHHKYSVPPVNFLPVPSRTRINNPACHKPVIPNNSFVSNQIPEVEKASESEESDEDDGPAPVIVENESYVNLKKKISKRYDWQAKSVHVENGKICKQFRMKQASRQFQSILQERQSLPAWEERETILNLLRKHQVVVISGMTGCGKTTQIPQFILDDSLNGPPEKVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDTALQGVSHIIVDEVHERTEESDFLLLVLKDIVSQRPGLQVILMSATLNAELFSDYFNSCPVITIPGRTFPVDQFFLEDAIAVTRYVLQDGSPYMRSMKQISKEKLKARRNRTAFEEVEEDLRLSLHLQDQDSVKDAVPDQQLDFKQLLARYKGVSKSVIKTMSIMDFEKVNLELIEALLEWIVDGKHSYPPGAILVFLPGLAEIKMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPAGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSAHNLQSVFSRLIEPPHTDSLRASKIRLRDLGALTPDEKLTPLGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLRAYKGWQLSTKEGVRASYNYCRQNFLSGRVLQEMASLKRQFTELLSDIGFAREGLRAREIEKRAQGGDGVLDATGEEANSNAENPKLISAMLCAALYPNVVQVKSPEGKFQKTSTGAVRMQPKSAELKFVTKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQRGEFVVSLDDGWIRFVAASHQVAELVKELRCELDQLLQDKIKNPSIDLCMCPRGSRIISTIVKLVTTQ
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis. Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7. Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The RING-CH-type zinc finger domain is required for E3 ligase activity.
Sequence:
MESKPSRIPRRISVQPSGSLSTRMVSGNRGTSLNDSYHSRDSSFRLDSEYQSASASACASPCQPAWYSESEIPQGARARAQTQQRDHDSKRPKLSCTNCASTSAGRNGGSGLNTVSDSSWRHSQVPRSSSMVLGSFGTDLMRERRDLDRRRESSISNLMDYNHRSGDFTTSSYVQERVPSSYSQGARPKENAVSTLQLNSSSTNHQLPSDHQTVPSSRDSSRSSFRSHFSPRQSESFRNSSHPAFSYFSSRNETPTISNSERGSSQRPYRESSDNEGRRTTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLSSENYISPRTLTSQSRNNGTSSSSDVSEGRAAEASQGFRFLRRRWGLSSLSQNHSSEPEAENFNQESEGRNSGPWLSSSLRNRCTPLFSRRRREGRDESSRMSTSDVPPRSHIFRRDSNEVVHLEAQGDSLGAAANRPQASGASSSAAAGGSTPELPQGGRNPGLTGILPGSLFRFAVPPALGSNLADNVMITVDIIPSGWNSTDGKNDKAKSAPSRDPEKLQKIKESLLLEDSDDEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQECMKKWLQAKINSGSSLEAVTTCELCKEKLQLNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTIEPSTRVRFINLARTLQAHMEDLETSEDEF