lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MKSRIPVVLLACGSFNPITNMHLRLFEVARDHLHQTGMYQVIAGIISPVNDKYGKKDLVAARHRVAMARLALQTSDWIRVDPWESEQVQWLETVKVLRHHHRELLRSLPQKEGLDRGKAHPAAPTVTNAETLSSQYIPRTAILCNFQTEDDVIFTGHDPSVTLLGSALVFPAVPELKLLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCVGRAGHDAERYILGLPILQKYQHNIHLAREPVQNEISATYIRRALSQGQSVKYLLPDAVIAYIKDHNLYTKDSSWKDNNT
The following text describes a protein:
Function:
Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Essential for coenzyme Q biosynthesis: together with FDXR, transfers the electrons required for the hydroxylation reaction performed by COQ6.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MAVSLLKRGVRASLMIGRFDPRVVLYPKPGQSLGRLSQATPEKLVTSNEEEGSRSVPTPAGTESDAENQRSELSEETVDVVFVDRSGQRVPVKGKVGESVLCLAHRCNIDLEGACESSLACSTCHVYVNTEFFDKLPEPDEREDDMLDMAPLLQENSRLGCQIILTEELNGAEFTLPKITRNFYVDGHVPKPH
The following text describes a protein:
Function:
Repressor for beta galactosidase alpha and beta subunits (ebgA and ebgC). Binds lactose as an inducer.
Sequence:
MATLKDIAIEAGVSLATVSRVLNDDPTLNVKEETKHRILEIAEKLEYKTSSARKLQTGAVNQHHILAIYSYQQELEINDPYYLAIRHGIETQCEKLGIELTNCYEHSGLPDIKNVTGILIVGKPTPALRAAASALTDNICFIDFHEPGSGYDAVDIDLARISKEIIDFYINQGVNRIGFIGGEDEPGKADIREVAFAEYGRLKQVVREEDIWRGGFSSSSGYELAKQMLAREDYPKALFVASDSIAIGVLRAIHERGLNIPQDISLISVNDIPTARFTFPPLSTVRIHSEMMGSQGVNLVYEKARDGRALPLLVFVPSKLKLRGTTR
The following text describes a protein:
Function:
Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5.
Subcellular Localization:
Nucleus.
Sequence:
MEVTQRTQSQTQPTQQSPTTQTQTQSKEDQNRICQLICSTGQFGNYDLNINDKTIVQGKMTWYFGRDPNSDLQVASSSRISNKHFQIWFNFNDKSLWIKDTSTNGTHLNNSRLVKGSNYLLNQGDEIAVGVGRDEDVVRFVVVFGDKYNPAKLPDSTNTIKDEGIYKDFIVKNETIGQGAFATVKKAIERSTGESYAVKIINRRKALNTGGGSAMAGVDRELSILERLNHPNIVALKAFYEDMDNYYIVMELVPGGDLMDFVAANGAIGEDATQVITKQILEGIAYVHNLGISHRDLKPDNILIMQDDPILVKITDFGLAKFSDNSTFMKTFCGTLAYVAPEVITGKYGSSQMESQQKDNYSSLVDIWSLGCLVYVLLTSHLPFNGKNQQQMFAKIKRGEFHEAPLNSYDISEDGRDFLQCCLQVNPKLRMTAAEALKHKWLQDLYEEDSVKSLSLSQSQSQQSRKIDNGIHIESLSKIDEDVMLRPLDSERNRKSSKQQDFKVPKRVIPLSQHPATPLPMSQPKKRPYQIDPRTNKKVDLEEPSTSKKVKLSDSVVAEDYLKLEPLANSLFQETINISKSPFSFGRNDTCDCEIDDDRLSKLHCVITKENDSIWLLDKSTNSCLVNNTSVGKGNKVLLRGGEILHLFFDPLSSQHIGFKVVLVDQSSGEHKSQVEALKQTSEEMNIIPLISGLSSISS
The following text describes a protein:
Function:
GTPase-activating protein for the ADP ribosylation factor family.
Sequence:
MSNYHPHSHPHALSHPHPQQVHNQLQNPHQNQLPPPQRHNHAAPTAAASASGAPSSSASASASASILVAHPPQPLISNSLAIRQEIQRFESVHPSIYAIYELIDLLPMADAQIAQSIRDHVVCIEDSFVNSQEWTISRSVPDLRLGIVGSLNSGKSALVHRYLTGSYMQEESPEGGRFKKEVFIDGQSYLLLIRDEGGAPEMQFAGWVDAVIFVFSLENEGSFNTVYNYYTKMAHFRNGQEIPMILVGTQDAISERNPRVIDDTRARKLASDLKRCSYYETCATYGLNVERVFQDACQKILSQRLPLPPQVQPARPTTPQGNRLGLAPYQAPTNGQRGQQQLPLRMSADFAQAEQKLWSLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGKELPTPTSTPTTSRKSRRRSNLFIPSSSKKADKEKEPKSSELGSGRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQKPRGSKSIITNSALTSSLMANGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQTSGDEGIAMSNSNSQTFIAGEVANAGNKLEAQTPNVKKRHRRMKSSSVKANEADDNDGYEFYIVSLDSKQWHFEAANSEERDEWVAAVEQEIFKSLQSIESSKTKQATSTDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNTRQRVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSPSPGQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQSLATAKSIKAAAAAQAGTTIPAPAPPTNGGIPAPQYNVEDTTALVELLEGLGCPEAAPLTASGTLPRRRDTLGTPYEKSVSGVI
The following text describes a protein:
Function:
Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.
Subcellular Localization:
Virion membrane; Multi-pass membrane protein. Host Golgi apparatus, host trans-Golgi network. Host endosome membrane; Multi-pass membrane protein. Host nucleus inner membrane; Multi-pass membrane protein. Note=During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs.
Sequence:
MRASKSDRFLMSSWVKLLFVAVIMYICSAVVPMAATYEGLGFPCYFNNLVNYSALNLTVRNSAKHLTPTLFLEKPEMLVYIFWTFIVDGIAIVYYCLAAVAVYRAKHVHATTMMSMQSWIALLGSHSVLYVAILRMWSMQLFIHVLSYKHVLMAAFVYCIHFCISFAHIQSLITCNSAQWEIPLLEQHVPDNTMMESLLTRWKPVCVNLYLSTTALEMLLFSLSTMMAVGNSFYVLVSDAIFGAVNMFLALTVVWYINTEFFLVKFMRRQVGFYVGVFVGYLILLLPVIRYENAFVQANLHYIVAINISCIPILCILAIVIRVIRSDWGLCTPSAAYMPLATSAPTVDRTPTVHQKPPPLPAKTRARAKVKDISTPAPRTQYQSDHESDSEIDETQMIFI
The following text describes a protein:
Function:
Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis. Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5.
Subcellular Localization:
Secreted.
Sequence:
MFHVSFRYIFGLPPLILVLLPVASSDCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQVKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH
The following text describes a protein:
Function:
Involved in the degradation of the pyridine ring of trigonelline (TG; N-methylnicotinate) into succinate and methylamine as carbon and nitrogen sources, respectively. Catalyzes the hydrolysis of (E)-2-((N-methylformamido)methylene)succinate (MFMS) into formic acid, succinate semialdehyde (SSA), methylamine and carbon dioxide.
Sequence:
MISKTLQLSNNRTAHYFEQGEGEPLVLIHGVGMQAEAWYPQIEYFSKHYHVISLDMPGHGQSTALAADAQLQDFVDWAIECIHTLNLGPVNLAGHSMGSLITTGVSVTRPDLVKRMAVLNGVYKRTHAAREAVIQRAEALKQGHLDIETPLQRWFGQSEIEKIASERVKLWLENVNMSGYTTAYRAFAQGDLVYADGWSDIECPALVLTGTDDPNSTAEMTIQMAHQAKHGTAIVIENERHMVNLTAPEKVNQAMQAWLETTP
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHKVHIIYSRIFQMTVTYNRAVSTESIHNFVSIMSYWHGSLVKSIWKEYAIWIVLYHLILFIYRVVMPIFGWADYCKKVIENWTPHQDMTIPLEFLLGFFVTTVIDRWRKAFQNIPYIEICAFAVAAAIPGRIRIINKKQNEVRAPGGQDLRDVPAVEVNHPVQRGPEAPAAALPMPGAPERPAVALPMPGAPEGPAAIQQPSVDVKLTARRTIIRYLVLSQILLFREISTKVKKRFVDLKCLVDSKFLTDEELKILSKEVKCDHYDSYFLPINWAFSILQEHKVKSNPEFINAWNVIRDWQVKLSLLRNGDFIPIPLAYPQAVFLAIRFYFLVCLFTRQHLDMDDKKSIDYYFPLMTSLQFIFIVGWMKVAEILLNPMGEDDDDFELNNIIDKNLYIGLAIVDTECGKHPEIVKDTIGKDCLPFYPQNDDDNERNRALVGSTKNINLSGRSDTPAASPSVFYVNINVKVENPTPVIVDGARPPPSPPALPPALPNPNEPPPPPPPAEALRADQPRHSLIHEVGAQADPAEANGAQALSPVLPNPNERADEHGHSPVIDNEAQPSPPPAEANRAPIPNQQPQVNGNAAPASPRQAKVPDDPH
The following text describes a protein:
Function:
Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
Subcellular Localization:
Secreted.
Sequence:
MLAKYFFSGLLLQMPRIDGVESQTISEFIQPHDVEFQSFNFNNTLHWKIKQTHTSHRAVYFVQYKMYGQNWKNKEECWGIQEDFCDLTNETSAVRDPYYGRVKAALAGVSSGWSISSRFNPWWDTKVGPPSHIRVSRSNGLISVTFQAPNSPYKSKNGSNIPMSNYHSLSFQVYQTSAIHHTLEKKKVYEGTDTVFVIDDVAPWSSFCIRAKTHLSFLDHSSPESKETCSAPVE
The following text describes a protein:
Function:
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
Sequence:
MHIGGYFIDNPIALAPMAGITDKPFRRLCRDFGAGWAVCEMLTSDPTLRNTRKTLHRSDFADEGGIVAVQIAGSDPQQMADAARYNVSLGAQLIDINMGCPAKKVCNVQAGSALMQNEPLVAAILEAVVRAAGVPVTLKTRLGWHDDHQNLPVIAKIAEDCGIAALAVHGRTRTQMYKGEARYELIAETKCRLNIPVWVNGDITSPQKAQAVLKQTAADGIMIGRGAQGRPWFFRDLKHYAEHGVLPPALSLAECAAAILNHIRAIHAFYGDTAGVRIARKHIGWYIDEMPDGEQTRREINRLDSAAAQYDMLAGYLERLAEKTDSWACAYRPNAF
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Domain:
The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.
Sequence:
MTDSAYRVDTISRLAQWRIHNLSSSTYRKSDPFKMGLWNWHLSVEKSKMLLNVKLYPEVSNLTRENPPVASFALRVVSSTGERKALSHPEVIDKRIKTNEDFIWTIEVPLTGKIIIDVEFLDLKVLSQDSGELYSIWANGSTENQSQVTAVTSLGRMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIYGNIQNEDFLIHRLALLQAAEKYDIADLKEACHLSLLDDIDTKNVLERLQNAYLYQLPELKASCMRYLVKFGKIFEIRDEFNIFMQCADRDLISEIFHEVLSTWKGF
The following text describes a protein:
Function:
Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Cytoplasm, cell cortex.
Sequence:
MGVNSSKINDKDRSILSIKEQRDKLLRYSKRLEKIEQLEIDIARKCLRDSDKRGALRALKAKKLYSGLITQTYGQLGNIEQLLSTIEFTLIQKDVMFGLQEGTNLIRQLQADMPLERVGRICNDRDEAMSYVDEVNDMLQGRMSRDQEDEIQEELDSLIREQEDEKVKDLEKPGFTPSTGVDVLPSVPLKNAIPSLDESFPKAASVSNTSSAVVIDEELRKDPVLG
The following text describes a protein:
Function:
Part of the ABC transporter complex GlnHMPQ involved in glutamine transport.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKDNDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRIPMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKVLAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKNYQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MDQTEKISQIIKNQSEFIACIVIKEKHIKQKKQIMLKLNKNSKRIDEQKRIREIVTYSTIFHRNIPGFIIQGGDPTVFYEQVKGGECIYGKYFEDEIVPEIIHDRREIVSMANAGKDSNQSKFYITYSKQNHLNGLYTAFYQVISGWEALDLMEKETGDNNYKPLNEIKTFKKAIHTNPIAEIEQF
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MDKVEIFNKIKTIITPFSKAPDAVAQATYASRFLEDLQINSARLIDIVLAFEDTFNIEISDDQADSILTIEDAVNLISSQVKTVAV
The following text describes a protein:
Function:
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MVLSSQLSVGMFISTKDGLYKVVSVSKVSGNKGDTFIKVSLQAAGSDVTVERNFKAGQEVKEAQFEPRNLEYLYLEEDKYLFLDLGNYDKIYIPKEIMKDNAMFLKAGVTVFALVHEGTVFSMELPHFLELMVAKTDFPGDSLSLSGGAKKALLETGVEVLVPPFVEIGDVIKVDTRTCEYIQRV
The following text describes a protein:
Function:
Component of a regulatory network controlling visceral mesoderm development and midgut morphogenesis. Transcriptional regulator involved in the activation of a large number of genes in the visceral mesoderm including betaTub60D, dpp and Hand. Binds to and regulates a number of enhancers driving expression in the visceral mesoderm in a temporally and spatially restricted manner. Also to binds to enhancers cooperatively with activators, such as bap or HLH54F, to coregulate expression of shared target genes in the visceral mesoderm. Binds to the Ndg enhancer and drives expression of Ndg in the late visceral musculature. May be involved in the transcriptional regulation of wupA in the visceral mesoderm. Plays an indirect role in the later stages of salivary gland positioning.
Subcellular Localization:
Nucleus.
Sequence:
MIKSEEASDRSVMTMDQLGGYYHDPRAHPPFSHPHAHSHPHQHTHTGHPYRAGNLLTGGNYQAMGGGESPTELIDEKPNIGYMELKHYMDATPTATPVSAAQHYSLSALHSMGTPPASSSPIPPYGVLMTAHSAGSASPQSNSKTPTDLPQDLQYASSSTSTAKVQPLQVQLQPLNHQYASTIKYCSNNTILSANDYQLLTSQEQAGQQQPQQLPAQQLQHSPGGGYMSRISTSPSQVISNAHGMPVLNYSSSSSSPAKSLNGSESSPPSQNHLENKVSGSAVVGTGGSSQQDAPSTPDTTKKSGTRRPEKPALSYINMIGHAIKESPTGKLTLSEIYAYLQKSYEFFRGPYVGWKNSVRHNLSLNECFKKLPKGMGVGKPGKGNYWTIDENSAHLFEDEGSLRRRPRGYRSKIKVKPYAGHANGYYASGYGDAGMDNGNYYASPAFASYDYSAAGATGVSPAGGQGFADPWNAHAAHSGSSSVGVGMGVGPLPQYTNISCLAAGGNVNGSATTPPLAHSALGMAPSASSSSSPLGAAATLQSDYAPTASLVAAGYSYATSAGSLDNGLRSISLQQLPGLSSIQHAQAQAQAQAHHHHHQHHASHPSHSHQGHGSMHQNHGTSSTTPPPSQSGGSHGIDHSPIDRKPAYLPPISPPPMMVALNGGGGYYEGLKYAN
The following text describes a protein:
Function:
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
Sequence:
MTSPHTIVFDLDGTLVDTAPDLITALNYVLDREGLPPVPMQSARNMIGAGARKLIERGLEAEGRIVTPSDMDRMTADFIAYYAEHIAVESRPFEGLETALDHFAAQGHRLAVCTNKLEWLSKRLLDQLDLSRRFAAICGADTFGVQKPDPAIFRETVARAGGEVKASIMVGDAGTDVGVARRAGVPVIGVSFGYTDVPIAELKPDRLIHHMRDLPAAATSLMTPLGSARS
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them.
Sequence:
MATKMAGSVQVVKDDTVKRTPMARPSIGREGKPIRLLSNHFAVKLNGVDAVFYQYSVSIKSEDDKVVDGKGIGRKVIDKLLQTYSSELDGKDFAYDGEKCLFTVGPLPQNNFEFTVILEETSSRAVGGSPGHGSPSQADKKRVKRSHLAKKFIVAISYAAKIPLKSVALALRGSESEHAQDALRVLDIVLRQQQAKRGCLLVRQSFFSDDSRNLVDLTGGVSGCRGLHSSFRTTIGGLSLNMDVSTTMIVTPGPVIDFLLTNQNVRDIRDIDWPRARKMLKNLRVKAKHNNMEFKIIGLSDQPCSRQTFPMKVRNGSIEVQTMDITVQDYFKSKQVELMMPYLPCLDVGKPKRPNYLPIELCHMVSLQRYTKALSSQQRANLVEKSRQKPQDRMRVVTDLVVGNSEDCIPNRGRWNYNNKRLLDPVKIERWAIVNFSARCDMSRISRELINCGRSKGIFIERPHTLVDEDSQSRRCSPVERVERMFEKVKTSLPGPPEFLLCVLPERKNCDIYGPWKKKNLHEMGIVTQCIAPSNKMNDQYFTNVLLKINAKLGGMNSKLALEHRQMIPVVTQIPTLILGMDVSHGSPGRADIPSIAAVVGSRCWPLISRYRASVRTQSPKVEMIDSLFKPLYDGKDDGIMRELLLDFYQTSQQRKPKQIIIFRDGVSESQFSQVLNVELNQIIKAYQSMGQGDLPKFTVIIAQKNHHTKLFQVDSPDNVPPGTVVDSGIVHPRQYDFYMCAQAGPIGTSRPTHYHVLLDEIGFSADNLQKLVLSLSYVYQRSTTAISVVAPICYAHLAAAQVGQFMKFEEFADTSSGSGVNSSSAAAIPELPRLHADVCSSMFFC
The following text describes a protein:
Function:
Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres; [Isoform 2]: May play a role in the assembly of focal adhesions.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Expressed in non-muscle cells. May be transcribed from an upstream promoter active in non-muscle cells.
Subcellular Localization:
[Isoform 2]: Cytoplasm.
Sequence:
MRVPVFEDIKDETEEEKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQDTHTYSAELDRPDIKMATQISKIISNAEYKKGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQNISSVKYKEEIKHATAISDPPELKRVKENQKNISNLQYKEQNYKATPVSMTPEIERVRRNQEQLSAVKYKGELQRGTAISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVDLKVWRTDPGSIFDLDPLEDNIQSRSLHMLSEKASHYRRHWSRSHSSSTFGTGLGDDRSEISEIYPSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFVN
The following text describes a protein:
Function:
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MDNAREVALDVLKAVLFEGAYSNIVLSKKLNKSNLKDNDKALITEIVYGTLKYKETLDIIIQSYLRNPIKTMDKNIVNILRITIYQIRYLDKIPSFAAVNEAVEMSKKISIKYSKLVNGVLRNYIRTYKNKKFYDHRNNLEKFSFMYSYPKWLIKMFISQYGIEIAEKILKGLNERPNITVRVNNLKIDYDEAFEKLGEYGYNIEEGYICPEAIQIIKGKNIEKNPLFIEGNITVQDESAMLVAPSMELDEESIVLDLCSAPGGKTTHISEIMNNKSKVYAYDVHQNKLSLIESNAKRLGIKNIETDVGDAAVFNKKLKEKAHRVLMDVPCSGLGIIRKKPEIKWTKNEREIKNIIAIQRKIMNNGASYLKEGGILLYSTCTLNKEENEENINWFLKKHKNFKIEPLYYGDVDNIIYHKEGFVSILPNDKMDGFFIAKLKKC
The following text describes a protein:
Function:
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MFLFPVAFLPVIFTVDFASPSALQHWNCPNGYRLKSESSACVDIDECLEGGLGTCGQTCTNVPGSYFCSCLPGYTLDIDKRSCYVNDPAPFLLFHHGSAIYRIDTEGTNHERLVDDAGPSGLMDFHYTEEKVYWVDSEKRLLQRIHLNGTKRERLCYIDKGISGFAIDWINRDILWANRQKATIEATDMNGKKRRVLLRDIGRPTKIAIDAEQRILFWSSDGTVSSIYRMSLNGSDVRNILRTTEKIKAISLDFVDIRLYWIQHDHGKEISHIGSCDYEGSAVHLLRSSSRYQLLGMSLFADHLYYSELKSGTIWTANKYTGKAVVTISLKPSLFSLVEIKVVHPFKQPGARTDLQEFEKGICDLNKEKCRRRICRPDSRTHRCKCSSGFILSRNKQFCEDINECGFWNHGCTLGCVNIPGSYYCTCPRGFVLLPDRKTCHELISCLNNDTECSHGCLQTSKGPVCFCPEGSVLKEDGKACTGCTSPDNGGCSQICSSLSPFSWECACFPGYKLQRDRKHCTAIGPRPFLLFANGQDIRRISFDGTDYASLLDGQMGVVLALDSDPVENKIYFAHTALKWIERANLDGSNREKVIHGAIDIPEGLAVDWINRKLYWTDRGKACIERSTLNGMQRKMIIWEGISQPRGIAIHPFVRRLFWTEMGIRPKIASSSLEGMDRRVIASMGLVHPSGIALDYLANKLYWCDAKQSVVESANLDGSGRRILAQNDVGHPFAVAVFEDHLWLSDWARPSLMRVDKKTGQNRVRLRGSMLRPSSMVVVHPLAKPGANPCLHMNGGCDQICENNFGVAHCTCRPGFGKTQDGQTCHPLNASYVTAETISMQKEAGPMPTPKTSLQSTQSNAIFKGTENGEKKEIELFLMAEIMISDEDDCAALECDANAQCVLLEDGAVCQCLKGFTRMGKSCYDVDECAANMDHCNRNLSGCINTEGGYVCKCLDGYTGDGLHCEDIDECKMGTHTCGENRTCTNTEGNFTCSCPDGASGTAMGCESTLSPTVVSNEYSTRPVPGDSIGCPPAYDSYCLHGGVCNYVSDLQDYACNCVTGYVGERCQFSDLEWWEQQHAERVKVRNITIAVCIAVLLLLLGSLAAYCSRSQNFYKKNRYAEAIRDASSHTDNENVTPTCNKSRFAVVKECSSALETKVLDLIECETANPHPACPSQYVEQPITYDKEAETVVEEKKEQGCPEDVPSTEKLLEPMVAEKSLSQAAWKAHSKPCQPAPASLLMQPD
The following text describes a protein:
Function:
Serine/threonine protein kinase required for state transition by phosphorylating light-harvesting complex II outer antennae (LCHII). State transition plays a central role in response to environmental changes and allows to adjust to changing light conditions via the redistribution of light excitation energy between photosystem II (PSII) and photosystem I (PSI).
Subcellular Localization:
Plastid, chloroplast thylakoid membrane.
Sequence:
MALAQRQVSCRIERSTGASTSQPVGSCLLVQRRPGQRRGVPARATPEFIDALSALVPNLPLEQIAAPCQVMKCGDIVYRSTLDPSLYNEAGFDEKTVALLAPVLAYLFLPPGVLPGAIDYYIRAPLKRKQTKAIDKNDIVLGKRLGTGGFGTVFKGELKEEGGVKTSIIIKKAKEFGEAEVWMNERMSRVAGHHVAEFVTAFDESLNVPLPAAAGKRAAPVQPTSPLDANSIWLVWVYEGDNTLSSLMERREWPYNLEPLLFGRELRAPRGPVRELVTIKEAFRQLVQAVAACHSVGIVHRDIKPANCIVSERDKKIKLIDLGAAADLRIGINYVPNEYLLDPRYAPPQQYIMSTQTPKPPPKPVAAFLSPILWTMEKPDRFDMYSCGITLLQMVFGHLRNDNALIAFNKRLQELKWDLPAWRREEEAKLPSAKGALAESLEAGFEALDADGGAGWDLLMRLLAYKPTDRPSAAAVLAHPWLTSAPGRTASLQHSLSGSFEATVSTAAAATSTALTAAGKSLGQAAKDAGLASMEEAILKVNQGALTEAQLMEELGLQEPAPVAPREGSQTIAWWQERQNELKARLVERREAMSESDPYGAAPSAMQVGSAINNARGGKGAKPTTPVKPTGPMAAAGAAAAAAAAAARVEAKVKVPNILGVKKPASGGGSNGRANGNGNGKAAPAKAANGNGSGNGNTNGNGNGAKQQLFGGLLGRKQQPVEEVQEEPEEEVEPEQETASKKERAFNLLGVFRR
The following text describes a protein:
Function:
The terminase large subunit acts as an ATP driven molecular motor necessary for viral DNA translocation into empty capsids and as an endonuclease that cuts the viral genome to initiate and to end a packaging reaction The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities. Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine. The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer. Direct long terminal repeats at each end of the genome are duplicated in concert with packaging. Once the capsid is packaged with the DNA, the terminase complex is substituted by the tail.
Domain:
The N-terminus contains an ATPase domain. The C-terminus contains an endonuclease domain.
Sequence:
MEVSRPYVNTVDVIDFGIDKRFFRLPVSGILAQEGITPNGPQIAIINALEDPRHRFVTACVSRRVGKSFIAYTLGFLKLLEPNVKVLVVAPNYSLANIGWSQIRGLIKKYGLQTERENAKDKEIELANGSLFKLASAAQADSAVGRSYDFIIFDEAAISDVGGDAFRVQLRPTLDKPNSKALFISTPRGGNWFKEFYAYGFDDTLPNWVSIHGTYRDNPRADLNDIEEARRTVSKNYFRQEYEADFSVFEGQIFDTFNAIDHVKDLKGMRHFFKDDEAFETLLGIDVGYRDPTAVLTIKYHYDTDTYYVLEEYQQAEKTTAQHAAYIQHCIDRYKVDRIFVDSAAAQFRQDLAYEHEIASAPAKKSVLDGLACLQALFQQGKIIVDASCSSLIHALQNYKWDFQEGEEKLSREKPRHDANSHLCDALRYGIYSISRGK
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MESEDGLELSLGLSLGGASAKSKGKITSSSGANAEESDRGNKLVDDFKSFLHGDNQRQESDTGSFQSNSIPSKDNFFNDLSKVGVDGDSSIDLKRKGAWIESNYAEAEDENLPEIGNKRKLLLMEMNSQKKQERESHHVDLHEKGRASFISSTEDGSTAEKGDVVESRAEGSTSRLASKHDDSSKQCIGETSLTKGSKDICGFSDSSGADLSRQKRFNNSSVGVSDAVQAMNMHNVPFPISVKDTNSLGAPSTSGHLQLGIQHVRPTVNGDRPGAELINPRNLPLMAGISPLQISAMDKDKSWGLVSHPQMIHHPYGGGGGLGGVSSSSAPGQVTGPFSSDGLLYGGRVTELTKGDNKQPAMEEGSSSRADHAKGSSSNMNAKDVLERSKTASVSLDFPAIKPGIAADIEFGGCGSYPNLPWVSTTAPGPTGKTISGVTYRFNANQIKIVCACHGTHMSPEEFIRHANDESFSAQNDNAPPTIPNKNPAASAQS
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
Sequence:
MSVQKVVVITGGSRGIGAATAKLFAQNGFSVCINYKSNAEAANTLVEEIKALGGHCIAVQADVSKESDVVKLFETVDQELGVVSVLVNNAGILKKQMRLDEMSAERINSILINNVTGYFLCCRETVKRMSTRHGGFGGVIVNVSSGAARTGSPNEYIDYAASKGAIDTLTKGLSLEVAAEGIRVNCVRPGLIYTDMHADGGEPDRIERLKNKIPMQRGGLPDEVAEAIYWLSSEKSSFSTGNFLDLAGGL
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MTAKMLHLVRYKFPSLEPASLFLIPGSFLQERFRRDILHRAVIYEADNDRQGTASSKRRNEITCSGRKLYRQKGTGHARVGDASSPIRRGGAKSHGPKPRDFSTKLQTQVYNLAMRIALSTRFINNELTILENPINLSQPKTRILLEVLKQHKLGHEYGKALFVLNDNYFEDESLKNNNLLLASRQLGYHCSFIPVGEFQVRDALKFGKLFIDSEAMSLIVEKFAQRNTLSDMDQPASLTAYVDANSSSFTKSKPEPSLSL