lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Recognizes N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines) produced by a broad range of DNA methylases and appears to act against 5-methylcytosine preceded by a purine residue. Binds to DNA containing methylated cytosines; also binds to GTP. Isoform 33 kDa is less active than isoform 51 kDa and may play a role in regulating the activity of isoform 51 kDa by competing with it in DNA and protein binding abilities.
Sequence:
MESIQPWIEKFIKQAQQQRSQSTKDYPTSYRNLRVKLSFGYGNFTSIPWFAFLGEGQEASNGIYPVILYYKDFDELVLAYGISDTNEPHAQWQFSSDIPKTIAEYFQATSGVYPKKYGQSYYACSQKVSQGIDYTRFASMLDNIINDYKLIFNSGKSVIPPMSKTESYCLEDALNDLFIPETTIETILKRLTIKKNIILQGPPGVGKTFVARRLAYLLTGEKAPQRVNMVQFHQSYSYEDFIQGYRPNGVGFRRKDGIFYNFCQQAKEQPEKKYIFIIDEINRANLSKVFGEVMMLMEHDKRGENWSVPLTYSENDEERFYVPENVYIIGLMNTADRSLAVVDYALRRRFSFIDIEPGFDTPQFRNFLLNKKAEPSFVESLCQKMNELNQEISKEATILGKGFRIGHSYFCCGLEDGTSPDTQWLNEIVMTDIAPLLEEYFFDDPYKQQKWTNKLLGDS
The following text describes a protein:
Function:
Putative gamma-glutamylcyclotransferase.
Sequence:
MPPCSIPSLASRNHGRRRSTREPHFRVRNAEKKPPEPFPLRGSHLKERRRLRRPTHDPVIVPARTGLYGIPYLINQPGSGKRIRGELYSVSKRGLVRLDELEGIKVEHYERLPVEVVEEEEESNGVVLAEAYFAHRRFGERLWEKRGKLGMCEFGVNDRVLYVRPKDRPRFSSVIAEIEAFVSSTND
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB24 is an atypical RAB protein that presents low GTPase activity and thereby exists predominantly in the GTP-bound active state. RAB24 is required for the clearance of late autophagic vacuoles under basal conditions. It is not needed for starvation-induced autophagy. Involved in the modulation of meiotic apparatus assembly and meiotic progression during oocyte maturation, possibly through regulation of kinetochore-microtubule interaction.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasmic vesicle, autophagosome membrane. Membrane; Lipid-anchor.
Sequence:
MNTFNFVESKVVLLGRNFSGKTCLLERYLHDRFLGTSEATIGAAYGTKTVTVRNTRVTLGIWDTAGSERYDAMSRIYYRGAKAAVICFDLTEEESFLRAKYWVNELHTYESSCRIYLCGTKFDLVEGKKKSRAVDAWVVSQYADGINAKLFETSSMTGRDVERLFFCVADDCGKEEYPQVEENDKELSKVKLEEPKNKRRNCCS
The following text describes a protein:
Function:
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNKLQEEWNRFCASWMFNTRLPILPFYVYSESTLSRSSRYFPLIGWIVSAGTSYSTYFLSWILPIEISIILGMILSVLITGGFHEDGLADVCDAFGGGWSKEKILEIMKDSRIGTFGSIGLILSLGLKYLLLVNLFKISPWIFLFTSWFSHSASRWFALLLMMLIPYARENDLSKSKPMIKKLPPFDFALSTFFGCFPAVYFLYQFQNQIPNVLLGFFLSSIFVFYFRNYFNKWIEGFTGDCLGFIQQGTELLFYLGITVSWNSI
The following text describes a protein:
Function:
Might contribute to the loading of the ESCRT machinery.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MAAELVSSATSEKLADVDWAKNIEICELAARDERQAKDVIKAIKKRLGSKNPNTQLYAVQLLEMLMNNIGENIHKQVIDTGVLPTLVKIVKKKSDLPVRERIFLLLDATQTSLGGASGKFPQYYTAYYELVNAGVKFTQRPNATPVVVTAQAVPRNTLNEQLASARNEGPATTQQRESQSVSPSSILQKASTALEILKEVLDAVDSQNPEGAKDEFTLDLVEQCSFQKERVMHLVMTSRDEKAVSKAIELNEQLQRILNRHEDLLSGRITVPSRSTTSNGYHSNLEPVRPISNGDQKRELKASNANTESSSFISNRAHLKLEEEDEEEEPEQLFRRLRKGKARARPEDEEEPSPPQGLPGSAIHNERLNRPLIRPLPSEEASRGGDSHSQSPPVVIPPPPAKHVEREKFFKENKGDGALGLPGHMRGLSLHSRDGSSSRSGSVDFSD
The following text describes a protein:
Function:
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPDTSYRTYNVDDYDPAQFYEHHENQGTPNSGPDVIQVRQFLDSNKLEDALKSVILLPPLGHAEQDLKERCTSLVVLVLHSFKSVDIEEMVRKLELEDGDILMNHMSVTADVAFASCGEIRTWIDNSSILWKVEIVMKSILELYNLNIKILTGNKICCKDGWSSEGEGSSKNGDVSENPSHKTVFIPRVITRSNEINRNSEETVIEEKIVFFACL
The following text describes a protein:
Function:
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
Subcellular Localization:
Chromosome, telomere. Nucleus.
Sequence:
MERNSTLRECGSVDPCTQLELTVNQWVFDYYFHIAVDAFRKDQHKDFQEIRDIVSVLLQRPLEMKAQNDCKVRIMQCLSRIEEGEDPDCTFNADNNETPLESAVGLLDIIQKEMPLDEDLLKTNKQMVKEAAVLVCIKNQKFDQAIRILKKYISNYSKRKLRAELQSIIQEKNQNHPLITNFSFTSIKKMIYQLFEKHIDVTAPILLTIAKKEQKLQCLSQDSQTPTTEQERTTLQLQNESPRSPQVVSSEADCVLSFGLSVLKSKFKSLCQDEDPDTIFTELCETDFCSLETPNDIPPEKAGTHTHTILKGHRKKLVVSLKQLVKEKDSQCINLSENSNVSHDRAHQAVPPAPKPQKPQITPKKRKLNPVLDRSDIVEEQDTWSEADELFKGKRENEKTSNNTTTNGRKQKWTQEETEWIIQGVKKFGEGNWKDIIKKYPFQNRTSVMVKDRWRTMKKLGIVPDD
The following text describes a protein:
Function:
Isomerase involved in the biosynthesis of carotenoids. Catalyzes the cis- to trans-conversion of the 15-cis-bond in 9,15,9'-tri-cis-zeta-carotene.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Major isoform in both etiolated and green leaves.
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MAVYHLLLSSPPSLLLLPPSPRRPNLTLIRRIPAHPRLGNSTSLLSSSSPVIRKILVRSTLREDQPIASDSESSPTLLIGEDSAAFELGKQKLVSWVYFGVVLGVVLFILNVVWIDNSTGFGKSFIDAVSNISGSPEVAMLMLILIFAIVHSGLASLRDIGEKLIGERAFRVLFAGISLPLAMSTIVYFINHRYDGSQLWQLQGVPGVHEAIWVANFVSFFFLYPSTFNLLEVAAVDKPKMHLWETGIMRITRHPQMVGQIVWCLAHTLWIGNTVAASASLGLIAHHLFGAWNGDRRLAKRYGEDFESIKKRTSVIPFAAIFEGRQVLPEDYYKEFVRLPYLAITALTVGAYFAHPLMQGASFRLHW
The following text describes a protein:
Function:
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MKGGAGVPDLPSLDASGVRLAIVASSWHGKICDALLDGARKVAAGCGLDDPTVVRVLGAIEIPVVAQELARNHDAVVALGVVIRGQTPHFDYVCDAVTQGLTRVSLDSSTPIANGVLTTNTEEQALDRAGLPTSAEDKGAQATVAALATALTLRELRAHS
The following text describes a protein:
Function:
Trithorax-group gene homolog required for early embryogenesis. Required for the expression of FLC and FLC homologs and represses flowering. Required for proper leaf growth and development. Part of COMPASS-like complexes responsible for H3K4 trimethylation, but not for di- or mono-methylation of histone H3 'Lys-4'. Binds to target loci chromatin, increasing H3K4 trimethylation and causing activation of the gene. Involved in the transition from transcription initiation to transcription elongation.
Miscellaneous:
MISCELLANEOUS: Named TRAUCO (TRO) in honor of the fertility mythology from the Chiloe island in southern Chile.
Subcellular Localization:
Nucleus.
Sequence:
MESLQSNSKIEEAEQNPKIEEAQVSVSLPEEPTGVLLPSELVDDSAPPESSDAVEESIETASEAEVSISLLEGTTTGTALLPSEENDLAPLESSGIIEEPIDTDLEKLDVVAMDVDQPGSDLKIESDSFSEEAPTTSSSDNPKSPKLDSVANQNGSAMEEDEGDEEQDDPPHKKLKQLDCLTSVAVKEEEEPEQVLPSEAMVVEEAATLVASAAKKSKSKKKNNNVWVTKSTRKGKKKSKANTPNPAAVEDKVLITPVPRFPDKGDDTPDLEICLSKVYKAEKVEISEDRLTAGSSKGYRMVRATRGVVEGAWYFEIKVLSLGETGHTRLGWSTDKGDLQAPVGYDGNSFGFRDIDGCKIHKALRETYAEEGYKEGDVIGFYINLPDGESFAPKPPHYVFYKGQRYICAPDAKEEPPKVVPGSEISFFKNGVCQGAAFTDIVGGRYYPAASMYTLPDQSNCLVKFNFGPSFEFFPEDFGGRATPRPMWEVPYHGFNGRLETNGSEDMKS
The following text describes a protein:
Function:
Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, cilium. Cell projection, stereocilium.
Domain:
The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
Sequence:
MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
The following text describes a protein:
Function:
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function, negatively regulating cell growth, probably via ribosome assembly. Stimulates the GTPase activity of Der; a construct missing the first 45 residues is even more stimulatory. Does not stimulate 2 other GTPases (ObgE and Era). Overexpression inhibits cell growth; precursor 16S rRNA accumulates, the 23S rRNA is 6-7 bases longer than usual, and 50S ribosomal subunits are improperly assembled, leading to 45S subunits lacking proteins L9, L18 and L25. Overexpression of Der in the same cells suppresses the 50S subunit assembly defect, corroborating that YihI and Der interact.
Miscellaneous:
MISCELLANEOUS: This is a highly hydrophilic protein; there is a stretch of highly charged residues in the N-terminus and a stretch of acidic residues in the C-terminus.
Sequence:
MKPSSSNSRSKGHAKARRKTREELDQEARDRKRQKKRRGHAPGSRAAGGNTTSGSKGQNAPKDPRIGSKTPIPLGVTEKVTKQHKPKSEKPMLSPQAELELLETDERLDALLERLEAGETLSAEEQSWVDAKLDRIDELMQKLGLSYDDDEEEEEDEKQEDMMRLLRGN
The following text describes a protein:
Function:
Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.
Subcellular Localization:
Cytoplasm.
Sequence:
MLALKENLLSVGSAPDNWGDWTLAAALVRGAADGTVFYTARAKASRPLVAVAAEQQGVHAIRLLAANDPFCAVTAEAGDSVPATVFTDLATVITGAPHLATVKTPIVVHIETLAEEYAAIPGFKDLGSVILVSSSPSQLLRAASTATKLAQASQRPVLHFYTSDLNGFGEVDVGTADGTFDSTIEDAPERILDSLQSRLVSRGTPSTLILNLSAYGEQFAQYLPDDVALYDITVYKPFEFSQVLRELPVSVKNIAVVQGSTGGSKSNGFEPILLDVFSDFNLLVDRGIKNIVVSGIGRLQYFAHTLEKIVSNSRSLSPSTDLYISDVKHAVHSGIAEEFIKKAISLENAYLSVLQQVFEPNLQLLNQFNDSAINSLRPEYGFGKFLQQNRARRQLMKMVERSLDCSLYEYEGPSVVEGLAAWISYNKRALDSSLLKEANILARDVHELLQKNSNSEVAKSILASAPTLDSFSFSSSWLIGSDAWSYDLGNSGVHHAITSRENINILLIDSEPYGSLSKNSARKKDVGLYAMNFGTAYVASVAVYSSYTQLLTAVVEASRFPGPSIVLAYLPYNSEQDSPLTILKETKRAVESGYWPLYRYNPTASNEEDTFKLDSSVLRRQLQEFLDRENKLTLLAKRYPDLSSNIVQSQSDIITAKQQRKSKEAYDQLLQGLSGPPLSVYYASDGGNAASLAKILAKKATTRGLKSFALSMDDIVLEDLPREQNVVFITSTGGQGEFPQDGKAFWEELKSATDLDLASVKFSVFGLGDSQYWPRKEDERYYNKPGKDLYNKLLLFSGQTLIPLGLGDDQDPDGYRTGYEKWESELWAALGVSDIITGEEPKLITNEDIKLASNFLRGTIAEALVDDSTGSIPSTDQQLTKFHGIYMQDDRDIRDVRKAQGLEPYYIFMIRARLPGGIARPEQYLALDKIAASFGNNTIKLTTRATFQLHGVVKRNLKSSIRAMNSTLLDTLAACGDVNRNVMVSALPANARVHEQVANVAAEISEELLPNTTAYHEIWLEGPDRNDASPEWQAIWEGMKSGPKKKVLVGGNALQDIEPIYGPTYLPRKFKVNIAVPPYNDVDVWACDVGLIAIIDETTSNLVGFNVYVGGGMGTTHNNKKTYPRLGSSFGFAPKEDITSVVEKILLVQRDHGDRTNRKHARLKYTIDDMGIDIYRQKVEELWGDKFAPERSYKIESNIDYFGWVKDETGMNHFTAFIENGRIEDSSKLSHKTGLRKVAEYMKQSGSGHFRLTGNQHIVISAIPDQHLDAIKGILKAYKLDNYSFSGLRLASSACVAFPTCGLAMAESERYLPQLISRLEESLEEYGLRHDSVVMRMSGCPNGCSRPWVAEVACVGKAPGTYNLLLGGGYYGQRLNKLYRSSLKEAEILSILRPLFKRWSLEREESEHFGDFLIRVGVIKPTLEGRKFHDDLPDGAI
The following text describes a protein:
Function:
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure.
Sequence:
MADSGRGTILQFAPFQSSVDEGFWHKLSSLKLNKLRLDDSPIPITGFYAPCSHPQVSNHLTLLAESLPAESNEESSSLPASQGNRNRCPVPGILLNTNTLESFHALDKQSLLKAESKKIWDEICSGKVEEDSSVLLRFLVISFADLKKWSFHYWFAFPALVLDPPATLVNLKPASQCFTSEEAESLSRACNEWRSLSSTADIPFFLVSFGSDSIVTLRHLREWEACQNNVQKVIFGFYDPCHLPSNPGWPLRNYLAYIYSRWGLGKIHFFCYRENRGFADLGLSLVGEAEISLSPGWRNHQNMPNTVGWELNRRKKVSRCISLAKTMDPTRLAVSAADLNLKLMRWRTLPSLNLDMLAATKCLLLGAGTLGCQVARMLMAWGVRKITLLDSGKVSMSNPLRQSLYVLDDCLNGGKFKAVAAVESLKRIFPAVEAEGVVMAIPMPGHPVPSQEESNILNDCRRLWDLINSHDAIFLLTDTRESRWLPSLLGASANKITINAALGFDSFLVMRHGAGPMGSIRNSQAETSNNISASMENLSISSQNGSQRLGCYFCNDVVAPIDSTANRTLDQQCTVTRPGLAPIASALAVELLVGVLHHPSGIYAKAEFANSNDNGSNEQPLGILPHQIRGSLSQFSQMTLVGHASTCCTACCSTVVSEYQTRGMDFVLQAINHPTYLEDLTGLTELMKSAGSYTLDWDNDSENDDDDDDCVEI
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MVRVFPACVFQPKCLLLFIVLVIFLIFAFTNPKQDEVKEEEQDYEITHRVYLDIDIDGQRQGRIVIGLYGEVVPKTVENFRALCTGTKHKGASGKALHYKGIPFHRIISGFMIQGGDVVYGDGRGSDSIYGSVFPDENFKIKHSHAGVVSMVNSGPNSNGSQFFITTIKASWLDGEHVVFGKVIQGMDIVYAIEGGAGTYSGKPRKKVIIADSGEIPKDKWDEER
The following text describes a protein:
Function:
Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
Sequence:
MRLFIAIEIPDEIKEFLYQLIYLKTSLDGVSIVQKGNFHITLKFLGEVNEGLIPDITNTLRKISNGFSPFTLKITHPGVFPDKFKPRVIWIGTENTDSLKEMAKRIDEEMESLGFKREDKNFKSHITVARVKNFHNGKYLFEKILKKFSGESSQLKFQVEEFVLMKSTLTPKGSIYDVLQRFPLVK
The following text describes a protein:
Function:
Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.
Sequence:
MELSGERKLRFKTSDGKIIESYENPFKLSQTIKDCLENNGGIPEEIPLESISSTTLKNIIKWLDFYKNLEFEEEVRDEQGHLGTCFLQEFDIKFFSTIDLIEINQILKASKFLDIDRLRRAGCAHMATLIRGSSVEEMKNFFAFDSDDDEEQMA
The following text describes a protein:
Function:
Mitochondrial triacylglycerol (TAG) lipase with activity toward long-chain diacylglycerols (DAGs) and triacylglycerols (TAGs). Involved in mitochondrial lipid metabolism.
Subcellular Localization:
Mitochondrion. Mitochondrion intermembrane space. Note=Imported into the IMS via the MIA40 disulfide relay system.
Sequence:
MKNDNKANDIIIDSVKVPDSYKPPKNPIVFCHGLSGFDKLILIPSVFHLTNLISNSIVHNMAENFMQDDEDKSDNKYTNLLEIEYWIGVKKFLQSKGCTVITTKVPGFGSIEERAMALDAQLQKEVKKIESKDKRHSLNLIAHSMGGLDCRYLICNIKNRNYDILSLTTISTPHRGSEMADYVVDLFENLNALRVSQKILPICFYQLTTAYMKYFNLVTPNSPKVSYFSYGCSFVPKWYNVFCTPWKIVYERSKGCPNDGLVTINSSKWGEYRGTLKDMDHLDVINWKNKLQDDWSKFFRTTTVGEKVDILNFYLKITDDLARKGF
The following text describes a protein:
Function:
Probable glycosyltransferase.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MQSNYSISYFLLILFTGTSSYFTIWNFVDHTRVGAFPEEDYIRLAYIIGGNFMTRLMFMQHFKSVLKYSDHFFRLHLITDENHRSDIHELMTSWNISNCEWFFHNLTEFEKRVAWIPNSHYSKYYGLSKLLIPEIIGNDIGKIMFMDVDIIFQTNIFDLWKQFRNFNNSQVFGMVENLSDWYLNKDGKKSVWPALGRGFNTGIIMFDLDKLRKNGWASKWRVVANKYLRIHGKTAMSDQDIFNAYIHDYPTEIIQIPCAYNYQLGALTKSKELCPETPLALHFNSQNKTVGKNYAFFDKIRKAFDEMDGSDLKRRRRSFKGNNQKDICHEYLPLDNFRIIPNAIGRMTKPAELCMVTQFSKDRLNHFLESANAWRHPISTAVYGKDKDLLDIAKAVTELNRTDITIHLVFEEPTESWMLDSLYPINFLRNVAIEHANCKYILMTDVDFVVLGDYGTIIDQTGNLKQKEVLVIPALEMTYPQLRLNLSNFLSRKDLVIEHLLNKTIQTFRETIWPSSHVPTNISKWIKSNRTYMVNYEKNYEPYFVIKKEECPFYDQRFGGFGWNKVTHVMQLKMMNYKFLVSPTSFMIHQNHNASKSLKRWRRDPHYQKCLHTLKNKFMKKTASRLGIKLR
The following text describes a protein:
Function:
Inhibitor of the metalloendopeptidase Mep72. Forms a protein-protein complex with the protease, which is the product of its coregulated adjacent gene, and probably prevents premature protease activity until the protein has been secreted.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MAKTWIYAASAAAIGGALIGGWLLDPAPPEASPQARQSPAAQAAAAPTAALAAPAADATRMLAPTPVTTPAPRERVTLWQGELRSREGAQGIPEYLAQVEPALLDTLALGQVLEMSLPGRERPLQARLASTHNSAGLPVWRGGLVDGDEAESLTVVRGSLETHINVATLDGSYSIIVDNRSGKTRVIDENDIAARSDPHGDHVDAPLAELPPMPPPAQG
The following text describes a protein:
Function:
Involved in the biosynthesis of the coenzyme M (2-mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde.
Sequence:
MKVDSSEAVYAGMKDAGIDFAVSVPCVNLRTVLEMVDADPAIMHVPVTREEEGFGVAAGAHMAGKTTAILMQNSGLGNSVNVLASLYSLYHIPITMIVSHRGTEGEFMEAQVPMGRATGDILRILEIPFRTPRSPAEARESIGELTDISLRTSKAVAVLLDVSYW
The following text describes a protein:
Function:
Promotes latency by binding operators O1 and O2 in the enhancer/operator region, thereby repressing the transcription from the Pe (early) promoter and blocking the expression of the genes required for replication (lytic growth). Competes with DDE-recombinase A for binding to the internal activation sequence (IAS), which overlaps O1 and O2. The outcome of this competition determines if the virus enters latency or starts replication. Makes the cell immune to superinfection by repressing genes expression of any subsequent incoming viral genome.
Subcellular Localization:
Host cytoplasm.
Domain:
The winged HTH N-terminal domain cooperatively binds to three operators O1, O2, and O3 with respectively 3, 4 and 2 binding sites. The C-terminal domain (CTD) regulates DNA binding by the N-terminal domain and degradation by ClpX-ClpP protease.
Sequence:
MKSNFIEKNNTEKSIWCSPQEIMAADGMPGSVAGVHYRANVQGWTKQKKEGVKGGKAVEYDVMSMPTKEREQVIAHLGLSTPDTGAQANEKQDSSELINKLTTTLINMIEELEPDEARKALKLLSKGGLLALMPLVFNEQKLYSFIGFSQQSIQTLMMLDALPEEKRKEILSKYGIHEQESVVVPSQEPQEVKKAV
The following text describes a protein:
Function:
Has a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MYNPYGNAADAYQQQQQQQYQQQQQQPHSTNLQHPQPIHHVSSHQPPPGAAGGQFNFLNDPAAALASQFARSGFEQSNQYLQENFGSLQGDIKYYFQVSNSYVFKKIILILMPYNHKDWNRVSTKETGTNQFLPPNLDINAPDLYLPLMSFVTYILLWAAFQGINGDFHPQLFGYLASQTIAFSVLDVVIFKTGLYLLNCPQSKIYDIISFSGYKYVSIIVLLILKYLVGNYLGLFYYIVVLLLIANLSIFLMRSLRFLILPQSTSMNNTITSKQRKIRIQFLFVYSVIIQGLIILYMSK
The following text describes a protein:
Function:
Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.
Sequence:
MDIIGGQHLRQMWDDLADVYGHKTALICESSGGVVNRYSYLELNQEINRTANLFYTLGIRKGDKVALHLDNCPEFIFCWFGLAKIGAIMVPINARLLCEESAWILQNSQACLLVTSAQFYPMYQQIQQEDATQLRHICLTDVALPADDGVSSFTQLKNQQPATLCYAPPLSTDDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQCALRDDDVYLTVMPAFHIDCQCTAAMAAFSAGATFVLVEKYSARAFWGQVQKYRATVTECIPMMIRTLMVQPPSANDQQHRLREVMFYLNLSEQEKDAFCERFGVRLLTSYGMTETIVGIIGDRPGDKRRWPSIGRVGFCYEAEIRDDHNRPLPAGEIGEICIKGIPGKTIFKEYFLNPQATAKVLEADGWLHTGDTGYRDEEDFFYFVDRRCNMIKRGGENVSCVELENIIAAHPKIQDIVVVGIKDSIRDEAIKAFVVLNEGETLSEEEFFRFCEQNMAKFKVPSYLEIRKDLPRNCSGKIIRKNLK
The following text describes a protein:
Function:
Plays a role in cell migration, axon fasciculation, and morphogenesis. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Involved in the anterior-posterior positioning of QR neuroblast descendants by regulating the migratory speed of QR.p. Probably by acting as a receptor for apoptotic cells, plays a role in the clearance of apoptotic cells during mid-embryogenesis.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Cell projection, phagocytic cup. Cytoplasmic vesicle, phagosome membrane. Note=Enriched at the cell contact with apoptotic cells and in phagocytic pseudopods during apoptotic cell engulfment. Co-localizes with src-1 during phagosome cup formation.
Sequence:
MRECIISWTLLLCLSCVKSFNLDVNAPIYRYGPSGTNFGYSVAEHFKGDKPVMLIGAPRGESGQTGTERAGAMYACDINTFYNGGSNHWCEQVRFEYENVEDYAKRPNETRGRTVHPLGKNDQLLASTIVSKGTKNGSALVCAPLIRYHQTAAYPQGACYELESNLRLQSTYATCAQKNLPTTDRHNEYGGCMEGFSAAITQDTIVTGLIGAVKWTGGVFAKKSSANIFDSVVEKYTMNQPNGDMIRTRLVAHDYLGYSVDIGRFGFWYEDGKPITVVSGATRYGEHGAVIFLPFIQDSSSKLTLNEDKFIINGTAMGSAFGYSIEVVDLNGDGFDDLIVGAPFEHRSGIDGNFGGIVYVYFSQGVQRKQHESHLVFHPPKILKNPDFYSQFGLSITKLGNVDGDKSKLNDFAVGAPFAFDGAGAVYIYLGTKNIEKFRKKPAQVIKGNDLPNLPPGGMRSFGFSLSGGSDMDENGYPDLLIGSPSKNFVALLRSRPVISIETKHKMEKRMVDIDKGVNCPRGAKTCFPLDMVIYVDEETKRGAELVDFSSDVFMCNLEAIPFRADTTARGFIEGSHSHNYSWPCGSNSHVQKRTYRQLIYLPVQESKDWITPLKFRFTVSIRNEKKPVQPPQGSQLVDLKHYPVLNKYGASYEFDVPFNTLCGEDHTCQTDLSLKAAFKDIPLTSNGYVSNVGEKDYLDLTFTVENKKEKAYQANFYLEYNEEELELPQVQGSKRMIAETIGKNIVHLPLGNPMNGASKHQFTIQFKLTRGRTEGIGKALKFMAHVNSTSQETEEELKDNKWEAEVQIIKKAELEIYGISDPDRVFFGGKARAESELELEEDIGTMVRHNYTIINHGPWTVRNVEAHISWPYQLRSRFGRGKNALYLLDVPTITTEFTDGTSEVRKCFIKQQYEYVNPAEIKLNTKYSTQETAPHRVEHRMKREIDEDEEEQSDDLGAVEENIPWFSTANFWNLFAIKGGDGRPREVKHLSCQDNTANCFTVICHFDFIDANSAVVIDLRARLWNATFIEDYSDVESVKIRSFGKLQLDESQGIDDDPNNNAAFVETSADPDRPTIGDSRPIPWWIYVIAAVIGVLILSLIIICLSKCGFFKRNRLDQPSLYTAQLKHEREEWADTGL
The following text describes a protein:
Function:
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MIAVSGGGTGGHFFPALAFTNYVLKKEKVKFIGSKRGIEYELKDLIKTEKLFLDVEPLRERNFYQKLKAIWKFLKAQEEINEFLKEDYRALIFGGYASLPLGINTVLRRKELFIHEQNSIPSKTNKILSKKAKKVLITFNYTKRFFPEGVRVGLPIRKELKKKLPKKEVKKRFGLEPDKITVLIFGGSQGALFLNELARDLKSVLPKEFQVILLTGKIHYEKFKNLEGEKFRVMPFSLDMGLIYSASDVAISRAGAGTINELSHFGVPSVFVPYPYAVDDHQFYNAKEIEKLGGGLVLRQEEAKPDKVLSALKEIVKNLERYSENIKKFFAEGAEERMYEELLG
The following text describes a protein:
Function:
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MELPDPVRQRLGNFSRAVFTDSNRTGPEYSEGPENEMVSSLALQMSLYFNTYYFPLWWVSSIMMLHMKYSILPDYYKFIVITVIILITLIEAIRLYLGYMGNLQEKVPELAGFWLLSLLLQLPLILFLLFNEGLTNLPLEKAIHIIFTLFLAFQVVAAFLTLRKMVNQLAVRFHLQDFDRLSANRGDMRRMRSCIEEI