lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.
Subcellular Localization:
Cell membrane. Membrane; Multi-pass membrane protein.
Sequence:
MVLQIRTDRDEDSNNRSPKCTLLSPCSHRLVTKDGHSLVKAVSMQGQGLMHLRDIWGLLLDMRWRWMMLAFSASFLAHWLLFAIFWYLLAEMNGDLAVDHDAPPENHTICVKYITSFTAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAVQMLLGLMLEAFITGVFVAKIARPKNRSPSIRFSRLAVVGNPEGKPCLMFQVANTRPSPLTMVKVSGILYQERGDGQIQQTNVEFLLDSQVSGAECPFFSFPLTYSHSLCSGSPLAVLLQRESLPSAGHLELVVCLSATQESSGEICQCRTSYLPSEILQGHRFAPCLTRRLEGGYRICMESFGRPLPELPQPSHRPPYRTDLEVCANGQRGDTFQICETGLGE
The following text describes a protein:
Function:
Pore-forming protein that plays a key role in granzyme-mediated programmed cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by mediating the passage and uptake of cytotoxic granzymes. Facilitates the delivery of cationic cargo protein, while anionic or neural proteins are not delivered efficiently (By similarity). Perforin pores allow the release of mature caspase-7 (CASP7) into the extracellular milieu.
Subcellular Localization:
Cytolytic granule. Secreted. Cell membrane; Multi-pass membrane protein. Endosome lumen. Note=Released from cytotoxic lymphocytes, together with proapoptotic granzymes: stored in cytolytic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes (By similarity). Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change.
Domain:
Perforin consists of three domains: (1) the MACPF domain, which includes the central machinery of pore formation, (2) the EGF-like domain, which forms a 'shelf-like' assembly connecting the MACPF and C2 domains, and (3) the C2 domain, which mediates calcium-dependent binding to lipid membranes. The C2 domain is critical for initial calcium-dependent interaction with lipid membranes of the target cell: calcium-binding causes a significant structural rearrangement, leading to oligomerization and deployment of the two transmembrane beta-strands (named CH1/TMH1 and CH2/TMH2) that enter the membrane as amphipathic beta-hairpins. The third calcium-binding site (Ca(2+) 3), which constitutes the weakest affinity site, triggers structural rearrangements in the C2 domain that facilitate its interaction with lipid membranes.
Sequence:
MATCLFLLGLFLLLPRPVPAPCYTATRSECKQKHKFVPGVWMAGEGMDVTTLRRSGSFPVNTQRFLRPDRTCTLCKNSLMRDATQRLPVAITHWRPHSSHCQRNVAAAKVHSTEGVAREAAANINNDWRVGLDVNPRPEANMRASVAGSHSKVANFAAEKTYQDQYNFNSDTVECRMYSFRLVQKPPLHLDFKKALRALPRNFNSSTEHAYHRLISSYGTHFITAVDLGGRISVLTALRTCQLTLNGLTADEVGDCLNVEAQVSIGAQASVSSEYKACEEKKKQHKMATSFHQTYRERHVEVLGGPLDSTHDLLFGNQATPEQFSTWTASLPSNPGLVDYSLEPLHTLLEEQNPKREALRQAISHYIMSRARWQNCSRPCRSGQHKSSHDSCQCECQDSKVTNQDCCPRQRGLAHLVVSNFRAEHLWGDYTTATDAYLKVFFGGQEFRTGVVWNNNNPRWTDKMDFENVLLSTGGPLRVQVWDADYGWDDDLLGSCDRSPHSGFHEVTCELNHGRVKFSYHAKCLPHLTGGTCLEYAPQGLLGDPPGNRSGAVW
The following text describes a protein:
Function:
Involved in the degradation of the monoterpenes beta-myrcene and limonene. During anaerobic degradation of beta-myrcene, catalyzes the NAD(+)-dependent oxidation of geranial to geranic acid. Seems to be specific for the trans-isomer geranial, since it does not act on the cis-isomer neral. During degradation of limonene, catalyzes the NAD(+)-dependent conversion of perillyl aldehyde to perrilic acid (Probable).
Sequence:
MTIDHQHIFVGGQWIAPKSTQRSNILNASTEELVGSVPKCNNEDMDRAVAAAREAMRSLAWAGLDGKGRAQHLRRFADAVERRGQQLARSVSLQNGMPINVADQLESAFVVSLLRYYASLAENLVEEEARPSPTGSTTLVRRDPVGVVGAIIPWNFPVALSIFKIAPALAAGCAVVVKPSSGTVLDSYVLAEAAAEAGLPPGVINWVPGDRGIGSHLVSHPGVDKVAFTGSTSAGRIIAEACARLLRPVTLELGGKSAAIVLEDADLDALIRSLPMSSVLNNGQACFSCTRILAPAGRYDEVVDAIAGAVSAYSVGDALDRATVVGPMASAAHRDSVQRYIELGTGEARLVVGGGRTSQDRGWFVQPTVFADVDNRSRIAREEIFGPVLSIIRYEGEDEAVEIANDSEYGLGGTVWSTDHDHAVTIARRMETGTVGINGYMPDLNAPFGGVKSSGMGRELGPESIGAYQRYKSVYLLG
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGRFSFNRYGYNTMQMESVESEKTRFEVECEFVQALANPNYLNFLAQRGYFKEEYFVNYLKYLLYWKDPQYARCLKFPQCLHMLEALQSQQFRDSMAYGPSAKFVEDQVVLQWQFYLRKRHRLCMMPDEGQELEESEDEADIRQKDTEDEDDEETMKKPDADTAEKNSTTSTVSKKEK
The following text describes a protein:
Function:
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Sarcoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MEKVQHITRSAMRRASNIEVNPQTRQNLQELFINFSLILICLLVICIIVMLL
The following text describes a protein:
Function:
Plays a major role in early metanephros and genital development.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MGNSYAGQLKSARFEEALHNSIEASLRCSTAVPRPIFSQLYLDPDQHPFSTADVKPKVEDLDKDLVHPYTQNGSVDFSHNVAMNEMEDDEDEEEMSDSNSPPIPYSQKPAPEGSCTTDGFCQAGKDLRLVSLCMEQIDIPAGFLLVGAKSPNLPEHILVCAVDKRFLPDDHGKNALLGFSGNCIGCGERGFRYFTEFSNHINLKLTTQPKKQKHLKYYLVRTSQGVLSKGPLICWKECRSRQSSALCHSTKPISSVSSAVAPENGTANGYKAGFTVTEAANGTSGHGGKSSSCSSTPSRPGNYSLSPRPTFTSVDQANMFISGPPKKRHRGWYPGSPVSQSALVVPAPTVRPLSRTEPLLSTPVPQTPLTGILQPRPVLAGETVIVPENLLSNSGVRPVILIGYGTLPYFYGNVGDIVVSPLLVNCYKIPQLENKDLEQLGLTSTHLLSVENMILLTIQYLVRLGPDQIPLREEFEQIMLTAMQEFSVRERALPLGAPCAPMSPAQLPWLARLAASVSQDLVHVIVTQNSLAEGISETLRLLSEMKHYQRLPDYVVAICASKIRGNEFCVVVLGQHQSRALAESMLTTSEFLKEISYELITGKVSFLASHFKTTSLGDDLDKLLEKMQQRRGDSVVTPFNGDLDECVSPQEAAAMIPTQNLDVDNETFQIYQPQLTVARRLLSQVCAIADSGSQSLDLGHFSKVDFIIIVPRSEVLVQQTLQRVRQSGVLVDLGLEESGLAHQRAERYVVRLDNEIQSKFEVFMRRVKQNPYTLFVLVHDNSHVELTSVISGSLSHGEPTHGLADRVINCREVLEAFNLLVLQVSSFPYTLQTQQSRISSSNEVHWIQLDTMEDAGCEKLYFGLDEYSKSLQWGITSPLLRCDETFEKMVSTLLERYPRLHSMVVRCYLLIQQYSEALMALTTMASLRDHSTPETLSIMDDLITSPGKNKSGKGHMLVIRVPSVQLAMLAKERLQEVRDKLGLQYRFEIILGSPASELTVETHFVTRLKTWRGNDQDEWIPRTYQDLEGLPCIVILTGKDPLGETFPRSLKYCDLRLIDSSYLTRTALEQEVGLACCYVSKEVIRGPAAALDLSAKEAERVPASENDSEELLIDLERPQSNSSAVTGTSGSIMENGVSSSSTAGKPQQQLLTPTSSIRLDEGVSASTAVVGEILKQECDSLDPPMASSTTSKPSSSSSSSAQALAWSRQPRGLHTALPPVIILSKAAYSLLGSQKGGRLPSSSSLLPHADVAWVSSLRPGLHKDMSSEEQSLYYRQWTSARQHHADYSNQPDPISGARTLHPRRLLLTGPPQVGKTGSYLQFLRILFRMLIRLLEVDVYNEEEINTDHSDDSELSQSEGEPWPDIETFSKMPFDVSVHDPKYRLMSLVYSEKLAGIKQEVIKEYKVEEPRQRETMSMMLTQYAAYNTFHHCEQCQQYMAFTPASQMSDSTLHAFTFSSSMLGEEVQLYFIIPKSKESHFVFSKQGRHLESMRLPLVSDKNLNAVKSPIFTPSSGRHEHGLLNLFHAMEGISHLHLLVVKEYEMPLYRKYWPNHIMLVLPGMFNNAGVGAARFLIKELSYHNLELERNRLEELGVKRQCVWPFIVVMDDSCVLWNIHSVQEQTSQPTEAGISSKNVSLKSVLQHIEATPKIIHYAILGIQKWNSKLTSQSLKAPFSRCHVHDFILLNIDLTQNVQYDFNRYFCEDVDFNLRTNSSGLLICRFNNFSLMKKHVQVGGQRDFIIKPKLMVSENVVPILPLQYVCAPDSEHTLLAAPAQFLLEKFLQHASYKLFPKAIHNFKSPVLAIDCYLNIGQEVAICYVSSRPHSSNVNCEGVFFSGLLLYLCDSFVGADLLKKFKFLKGATLCVICQDRSSLRQTIVRLELEDEWQFRLRDEFQTANSSDDKPLYFLTGRHV
The following text describes a protein:
Function:
Involved in the initial step of iron uptake by binding iron chelating siderophores, thereby allowing extraction of iron from the environment. Probably involved in the transport of siderophores, including host catecholamines such as dopamine.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MSRQSTDTAVSSQRLLASAIGVAITAIAAPQAAQADEAGQKKTDKDRVLSLDAATIVGEQQDETTYNVDRSASKKYTAPLLDTPKTVTVIPQQVIKDTGALTLADALRTTPGITFGAGEGGNPAGDRPFIRGFNAESDTFLDGMRDVASQTREVFNVEQIEVSKGPGSAYTGAGSTGGSLNLISKTAKQDNFTDAGFTWGSDQTRRTTLDVNRMIGDNAAFRLNLMKHDAHVAGRDEVSVSRWGVAPTVTFGFDTPTRATLSYYHLSTDDMPDYGLPLTNVNRSKANPSKPASVDRDNFYGLKDRDYRKSTTDSGTFRIEHDLNDNLTLSNSTRLVRTTLDYIVSNPDDSRGNVANGYVYRSAKSRNSTSKGWVNQTDLKANFETGFIKHTLVTGLEFSYEDVHNRPYAITSGGGAGNTCNARLLASGDCTSLNRPTPGDNWTGSITDGLAYTDTDTKTSAAYVFDTLKLSEQWELNLGLRYDDFDTKSSGYQTAGRNGPAGYFKRENNSHFWNYQTGLVYKPAPNGSIYLAWSTSSNPTGETGGEGQADISVGNNGLDPERNRNLELGTKWAFFDDALSLNAALFRTDKTNARVASPDVSTLQVLDGEQRVQGVELGFNGKLTEKWKVFGGYTYLDSEIRKSTVKSDEGNKMPQTAQNNFTLWTTYDLLQNFTIGGGTTYVDKQYGNTANSTYIPSYWRYDAMASYKVSKNVDLQLNVQNLTDKRYFDQVYSTHMAHVAPGRTALLGVNFHF
The following text describes a protein:
Function:
Alpha-ketoglutarate-dependent dioxygenase that in vitro catalyzes the regio- and stereoselective hydroxylation of L-lysine, leading to (4R)-4-hydroxy-L-lysine.
Sequence:
MKSQSIMSVERSAETSLTLEIPTSPLIIKITQQERNILSNVGNLLVKAFGNYENPDYIASLHLHAFQLLPERITRILSQFGSDFSAEQYGAIVFQGLIEVDQDDLGPTPPNWQGADYGKLNKYGFICSLLHGAVPSKPVQYYAQRKGGGLLHAVIPDEKMAATQTGSGSKTDLFVHTEDAFLSNQADFLSFLYLRNEERVPSTLYSIRSHGKMNPVMKKLFEPIYQCPKDANYNDEDVANSGPTASVLYGNRELPFIRFDAAEQIFNENAGQTSEALGNLMDFWDEAKTLINSDYIPNSGDLIFVNNHLCAHGRSAFIAGQRIENGEIIKCERRQMLRMMSKTSLIHIRSVTRTDDPYFIMEEHLGKIFDLD
The following text describes a protein:
Function:
Monooxygenase involved in the biosynthesis of carnosate, a potent antioxidant labdane-related diterpene natural product. Catalyzes the oxidation of 11-hydroxyferruginol to produce carnosate. Mediates the conversion of miltiradien into miltiradien-20-al (By similarity). Also involved in the production of pisiferic acid and derivative products from ferruginol (By similarity).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MQVLILLSLAFLASCVVAYSRRRPGGRGAGDLPPGPPRLPIIGNMLQLGQNPHKSLAHLAKTYGPLMSLKLGNQFVVVVSSPEMAREVLQRHGLVFSRPFTPIAVQILGHGEVSMNMLPATSPIWKKIRKIAREKLFSNQALHATRAVRRERLRKLADYVGRCSGAMNVGEATFTTMSNLMFATLFSVEITQYADSDSDSGVNKKFREHVNAITRYMGVPNIADFFPIFAPFDPQGLRRKLTYHLGSLLELVQSLIEQRLRARNAATYRKKDDFLEMLLDLSEGDEYDLSVNEIKHLCVDLIIAGSDTSAATTEWAMVELLLHPDKLAKLKAELKSVVGDKSIIEESDISKLPYLQATVKEVLRYHPAAPLLAPHLAEEETQLNGYIIPKNTKIFINDWTISRDPSIWKNPEMFEPERFLNNDIDFCGQHFELIPFGSGRRICPGLPLASRMLHCMVATLCHNFDWELEKGTESKQLQREDVFGLALQKKIPLRAIPIKV
The following text describes a protein:
Function:
Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.
Subcellular Localization:
Nucleus.
Sequence:
KTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQQQQQQPMPPTQLPLPLDGTPTPSGHPGSLCPTNAGLLGTPSPVPVKEEFLP
The following text describes a protein:
Function:
May function as linker between cellular membranes and the actin cytoskeleton. Required for normal development of fruiting bodies.
Subcellular Localization:
Nucleus membrane; Single-pass type IV membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane. Golgi apparatus, Golgi stack membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Note=The largest part of the protein is cytoplasmic, while its C-terminal part is associated either with the nuclear envelope, the Golgi membrane or the endoplasmic reticulum membrane.
Sequence:
MEHSTPLNEEIVHKKNDENWVIAQKKVFTNWCNIFLNQRSQKIEDLETDLYDGILLGSLLEILSGKNVILSKCKQLKTRLHYINNLNFSLKFIGDEGLRLVGVASEDITDGNLKLILGLVWTLILRYQIQSMQNSKSSQQNLHSSTKPSELMLNWVKSQISDYGHHIKDLTTSFQNGLLFCALVHKLVPEKLDYKSLSESDSLGNLTLAFEVANKELGIPSILDPHDIITTPDELSILTYISLFPKVYQQTLEPLNNNNNISPSLSSSSSSLLNTPNKRNSIQLSKSTSFEQQNQQQQQQNLLSPNSYRNSISFSKSPSFEGSQSTGSSRSISPISSPIKNSTTGNSNLSKSTSFEKIEASNTTNNNTIIIAEESRVIEKIVEKIIEVEKIVEVEKIVEVEKIVEVEKIVEVEKIVKVDDIEKLTNLQDQLTEQQQQYQEKSLKLVNLELELQEKSNQLVDKSNQLSTMQATNSELMEKIGGLMNDLTDIPTQDIKEKDEIIANLKIESEKNLKCFQDDFNALQSRYSLTIEQTSQLQDRIKQLINELQERDDKFIEFTNSSNQSLADNQRVIDQLTNEKQSITLQLQDQQDIKEKEFQFEKQQLLSQIDSITTNIQEYQDKFNNLQQEFNTQQTLNQQETHRLTQQLYQINTDYNEKQTQLQSEIKDNQTINEQLNKQLSEKDKEIEKLSNQQEQQQDEKINNLLLEIKEKDCLIERINQQLLENIDLNSKYQQLLLEFENFKLNSSKEKENQLNELQSKQDERFNQLNDEKLEKEKQLQSIEDEFNQYKQQQLSSNSNIDQQLQSTIIELSELKEQKELNDSKLIEKEKQLQQLQQEFDQLNEKNQKDHQDQLELLEKQLKQLQQEYDQLNETNQSIENQLNQQNLINKENLNEKEQELLKLQNQLNQQIEKIQFDQQEFSKQNSINIELVNEKNEKLIQLQQDYDQLKQQNRSNDEKDENDLIEKENQLKSIQNELNQLIEKNESDHKEQQLKQQSIENDLIEKENQIQQLQSQLNEQRQQQSNQLSEKDQQLNQLIEKNQFDQKEQQLKQQSIENDLFEKENQIQQLQSQLNEQRQQQSNQLSEKDQQLNQLIEKNESDQKEQQLKQQSIENDLIEKENQIQQLQLQLNEQRQLQSEVSIDNDKILELEKQLKQCQSDLLKLNDEKQQQDKQLQDKQIEFDQLQLTFNQFKNDKDSQFIQLQDDQKQQLQSIQQDLNQLKQENQEKEKQLSEKDEKLQSIQFENQEKEKQLSEKDEKLQSIQQNLNQLNDENQEKVKQFSEKDEKLQSIQQDLNQLKQENQEKEKQLSEKDEKLQSIQQDLNQLNDDQIKKNEKLKEKEEQLLKLQQDFNDQQSQQLKQLEEKLSEKENQLQQLKQENEINQLNQQQQSNEIIQQLKDQLLKQQQQEQQENNNEKEIERLIQEIEQLKQQQEIDQSELSNKEIKIQTTQQEFDQLSHNRSKDQLHLQQLQQELDQLKQSFDDQDHQFKKVIDERYNLQLQLEQSTLSNNQLDQLLKEKLKPLELDSNEKQKTIDDLLSNISNLQISLQNDKDLISERNNSIKTLESRITQQLSLLDEKDNLIKDLQQQKQQQQQPPTASSSPSSSPSLLSSTPTPKPQRPNQIEIDRLVNEIVNRNQDLIRKNKTKFYKLENGDYIVNSIIYRLSLDDDNDSDLIAQEYENGNSTTFEKSLRIFPSKNTRPIFDWRALFFIGAAVLAISTLFSSSRPIKYEKPT
The following text describes a protein:
Function:
Catalyzes three sequential steps of tetrahydrofolate biosynthesis.
Sequence:
MDKLIVKDLAVRNITGVDSWERSKQQPLIITVVGYTDVGLGGMHDLLSESVSYSAISKEAQKFAESSVFRSLEKLAAGIVYACLTKFPLECVSVKVLKPRALLHATSAGVELVQTVAADPYRRADILSINDLVLNCIIGVNAWEREERQNIIVNIQMFVELDDQALIADHVPKMQNYRTITRMLTKLVEESSYKTVEALAIRIAHLLIQVCFVPKVTIRIEKPSALTFAASAGVEITRTRSSLLNETHVPISLKDSASNAVVFLAIGSNLGDRAQNIHKALDCLINSKISIADTSFLYETSPMYITDQPLFLNCCIKIKTCLSPHDLLCLLKKIEADLGRDLHGGVCNGPRPIDLDILFYNQLELNSETLVIPHPRITERAFVLCPLCDIAPDMEHVGKFRTIRQELALLKHEESDDCIWKVMPVRGSVWRVDERTRIMGVLNVTPDSFSDGNKFMNVESAVSHSLKMVDENVDIIDVGGHSTNPGSDATCESDELERVTTSIRAIRKHNSSVPISVDTFRASIATAAIEAGADFINDISGGSKDPDMLKVMAASHLPVCLMHMRGDSKTMMSLTDYAGDVIGAIHSSMTDLVQAAIKAGVYRWNIMIDPGIGFAKTMDQNYEILKRLPDIAKPNTALEGFPILVGPSRKRFIGETLQENDPTKRGWGTAAACSAAVAGGASVMRVHDIKEMRDVILVADKCFRM
The following text describes a protein:
Function:
Required for nicotinamide riboside transport across the inner membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDFFSTHNILIHIPIGAGGYDLSWIEAVGTIAGLLCIWLASLEKISNYFFGLVNVTLFAIIFFQIQLYASLLLQLFFFAANIYGWYAWSRQTKDNQAELKIRWLPLPKAMAWLAICVIAIGLMTRYIDPVFAVLTRVAVAIMQMLGLQVTMPVLQPDAFPFWDSCMMVLSIVAMILMTRKYVENWLLWVIINVISVVIFALQGVYAMSLEYLILTFIAVNGSRLWINSARERGSRALSR
The following text describes a protein:
Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
Sequence:
MSKVLRHKPPPGAMDAAGWVNLPVLLRHLKNQPTEQQVREIVAACPKKRFVLDDTTNPPRIRAAQGHSVELEEAVLEPVTEASQVPVPVHVTGVDGWSAIQSSGELRRMKRTHVHFATAPHHLRNNKWAEVYLRLDLQAALDAGLQFGLSSNGVLLCEGPVPVALVKRVELDELPEEWRQGRGQQGQGQQEQGAEKKQRQGKGKAQQGQPPEQKDEGKERREQEAAVGGDKDTEGVKQDV
The following text describes a protein:
Function:
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Subcellular Localization:
Mitochondrion.
Sequence:
VFVNFSIIMAQFRCFYLGKIRYANALKLQQNLTQWQLKSPNANPILLMLQHDPVYTVGLRSNEYNENDESRLSALGADFVRTNRGGLITFHGPGQLVVYPIFKLADFKLGIRKYVCQLEATIIALCERYELEAVRSPHTGVWIGKDKVCAMGINARRGVTSHGLALNCNTDLEWFNRIVPCGIHGKGVTSLSHELSRDITVEHVLPHFLEHFSDVFKSKSLCFSDLTDKTTLSDLCDVITE
The following text describes a protein:
Function:
As part of the heterotrimeric replication protein A (RPA) complex, binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress (By similarity). It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (By similarity). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (By similarity). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation (By similarity).
Sequence:
MVTQLTKNAIDSLINSTNPDEQYVIQVLKAPQSVAENLFKICISDGFCKFKKGYFVSDAATKCQDLKDLCIIKCKKYIDDSNHDKERIIISNYELIYSNIQEQIGKPIEYKQYKSSGFSNPEGSTVIPSQYLSRNAQILQQNQVSQPKQMVTPPVSNINKPTPAVNNTFAQKPAVTNQNIQRVNQNPQQMNKTAPVKQNNNNNNNNNGNNKNNSSLQISTDGDEQNLEYIRNLQPNGQPQTIKVRITKKGDLKSFKEKQGKLFSIDVIDKFGDECSISFFNEIAEQYDGLFKVGQVIVLKQFSVKVNNNHQYNKGDHTVTVNKESKILICQEDPSIPMIKLNRQFIQDMQNKQKGDLIDLIVVVKADTEVKTMILKKDNQQQSKRDIISFDESLIETEITLWGETAKDYDAKQGDIIVFKDAKIGEFKDKKQINIGYGTQIFMNPDEQLFPQIHDVKKWYLSLNSDQLSTIQKAQGNDTGPREVTSFESSLNILKEEIKNLQTDPEMKIWKEIRGQIMYIKDTPLYYNACFSCKKKIARNNEVWTCINCNKDFNEPDSRYILSLNISDSTDTIWVSAFDEVGQKILGVKGDVFRYADEDTEHGTETKKKLLMAAQNKEYRFLLLTKQERDQNGNARDKTVIHAIKDFQPAYEAKKIINSLEKFMVIEENNP
The following text describes a protein:
Function:
Inhibitor of the caspase-activated DNase (DFF40).
Subcellular Localization:
Cytoplasm.
Sequence:
MARRGSALSALKQCLLRSNGRQEQHGVAAASLQELRSKACELFAIDTASQPVTLVLAEDGTIVDDEDYFLCLPPNTKFVALAKDEKWACSSIDGGTAWLEGEVTDIDGPESGEEKWQRLARQLKDDLSTIILMSEEDLQALIDVPCLDLARELSDTQAKVQALQETLQQVLDRREEERQSRQLLELYLQAVKNEDHIVPKREEATDTAMEEADTVDAGGSSRVAATVPLSSHILTALREKTAPELSLDSQDLELVNKEDPDVLAQALSWEKTKVLALQEACEQELSRRLQQVQALHSLRSFSKGKKKLPWGEWLSSKRKK
The following text describes a protein:
Function:
Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells.
Subcellular Localization:
Nucleus.
Sequence:
MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIRDFYQSRGLDRVSQPSGEEPALRGLGLPFTSFDHYYRYDEQLSLCLERLSSGKDKNKNVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHVQLLFDNEVLPDHMTMKQLWLSRWFGKPSPLLLQYSVKEKRR
The following text describes a protein:
Function:
Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
Sequence:
MNEIILITGAYGMVGQNTALYFKKNKPDVTLLTPKKSELCLLDKDNVQAYLKEYKPTGIIHCAGRVGGIVANMNDLSTYMVENLLMGLYLFSSALDSGVKKAINLASSCAYPKFAPNPLKESDLLNGSLEPTNEGYALAKLSVMKYCEYVSAEKGVFYKTLVPCNLYGEFDKFEEKIAHMIPGLIARMHTAKLKNEKEFAMWGDGTARREYLNAKDLARFISLAYENIASIPSVMNVGSGVDYSIEEYYEKVAQVLDYKGVFVKDLSKPVGMQQKLMDISKQRALKWELEIPLEQGIKEAYEYYLKLLEV
The following text describes a protein:
Function:
With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MLAAVRSASGFLQDSHSYLQALVTSYSLVYPEFSGWFHLVLGSSSVRARTMSWIKEGELSLWERFCANIIKAGPMPKHIAFIMDGNRRYAKKCQVERQEGHSQGFNKLAETLRWCLNLGVLEVTVYAFSIENFKRSKSEVDGLMDLARQKFSRLMEEQEKLQKHGVCIRVLGDLHLLPLDLQELIAQAVQATKNYNKCFLNVCFAYTSRHEISNAVREMAWGVEQGLLDPSDVSESLLDKCLYTNHSPHPDILIRTSGEVRLSDFLLWQTSHSCLVFQPVLWPEYTFWNLCEAILQFQMNHSMLQQKARDMYAEERKRQQLERDQAAVTEQLLQEGLQASGDAQLRWTRLHKLSARREERVQGFLQALELKRADWLARLGTASA
The following text describes a protein:
Function:
Involved in putrescine catabolism in peroxisomes. Copper amine oxidase that can use putrescine and spermidine as substrates.
Subcellular Localization:
Peroxisome.
Sequence:
MASASKKTSACPHHGGSLPPPKLVSAAPDTVAVWSDADDQRASKVSLESVIRPVDSFPDNTAKKPANKGISVMPRTETKHPLDPLSAAEISVAVATVRAAGANPEVRDGMRFIEVASVEPDKQVVALADAYFFPPFQPSLLPRTKSGPVIPMKLPPRRARLVVYNQKSNETSVWIVALSEVHAVTRGGHHRGRVVSSQVIPDVQPPMDAAEYAECEAIVKDFPPFIEAMKRRGIEDMDLVMVDPWCVGYHSEADAPSRRLAKPLIYCRTDSDSPMENGYARPVEGIYVLVDMQNMVVIEFEDRKFVPLPPPDPLRNYTPGESRGGVDRSDVKPLQIIQPEGPSFRVRGYFVEWQKWNFRIGFTPREGLVIHSVAYVDGSRGRRPVAHRLSFVEMVVPYGDPNEPHYRKNAFDAGEDGLGKNAHSLKKGCDCLGSIKYFDAHFTNFTGGVETIENCVCLHEEDHGILWKHQDWRTGLAEVRRSRRLTVSFLCTVANYEYGFYWHFYQDGKIEAEVKLTGILSLGALQPGETRKYGTTIAPGLYAPVHQHFFIARMDMSVDCKPAEAFNQVVEVNVRVDERGENNVHNNAFYAEEKLLKSEAVAMRDCDPLSARHWIVRNTRTVNRTGQLTGYKLVPGSNCLPLARPEAKFLRRAAFLKHNLWVTRYAPDEKFPGGEFPNQNPRAGEGLATWVKQNRSLEESDVVLWYVFGITHVPRLEDWPVMPVEHIGFTLMPHGFFNCSPAVDVPPNPCELETKESEVKEVVAPKALQTGLLSKL
The following text describes a protein:
Function:
Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MMETERLVLPPPDPLDLPLRAVELGCTGHWELLNLPGAPESSLPHGLPPCAPDLQQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAVLGAPVPSDLQAQRHPTTGQILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDEPTITDLNTREEAEEEIDFEKDLLTIPPGFKKGMDFAPKDCPTPAPGLLSLSCLLEPLDLGGGDEDENEAVGQPGGPRGDAVSASPCSAPLARASSLEDLVLKEASTAVSTPEAPEPPSQEQWAIPVDATSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLERHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPDHVSIILLSATVPNALEFADWIGRLKRRQIYVISTVTRPVPLEHYLFTGNSSKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSELLNRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALAELTKKLGALEEPDMTGQLVDLPEYYSWGEELTETQHMIQRRIMESVNGLKSLSAGRVVVVKNQEHHNALGVILQVSSNSTSRVFTTLVLCDKPLSQDAQDRGPATAEVPYPDDLVGFKLFLPEGPCDHTVVKLQPGDIAAITTKVLRVNGEKILEDFSKRQQPKFKKDPPLAAVTTAVQELLRLAQAHPAGPPTLDPVNDLQLKDMSVVEGGLRARKLEELIQGAQCVHSPRFPAQYLKLQERMQIQKEMERLRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSSHELLLTELMFDNALSTLRPEEIAALLSGLVCQSPGDAGDQLPNTLKQGIECVRAVAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATLLRRDIVFAASLYTQ