lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDWVIDTAKFLVNEILSQPAYLIGIITAVGLAALKKSVGQTVGGAIKATLGLLLVGAGAGLVSSSLDPLGRMIQGTTGTHGVIPTNEAIVGIAQSEFGARVAWLMILGFLVSLALARFTPLRYVFLTGHHMLFMATLLTIVMATAGQGSVAVVLGGGVLVGILLVALPAFAHPWTKKVTGNDTLAIGHFGTAGYIVSGATGQLVGKNSRSTEEMKLPEGLRFLRDSMVATALSMVLIYLVMSLLFLAKVGQDAAFKAFAGSGGDPAADVGNYLMQSVMQGLQFGIGVAVILFGVRTILGELVPAFQGIAGRVVPGAKPALDAPIVFPYAQNAVLIGFIFSFLGGLTGLAALIWVFNPAFGLALVLPGLVPHFFTGGAAGVYGNATGGRRGAAVGSFLNGLLITFLPAILLKALGSFGEANTTFGDADFGWFGAVLGSIGKLDGTAGLIGMLIFGLLILAGAWIMQTKVVDRGWIPGGGITAAPAEAAAVVPAQAAGTATYAKIAPPRGAPAPPPAP
The following text describes a protein:
Function:
Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Subcellular Localization:
Nucleus.
Sequence:
MSTTTTQIQPKPIPALYTVYILRSQPRHASLYIGSTPHPPRRLSQHNGLAKGGAYRTSKISLRPWNMVCLVSGFPSMIAALKFEWALNNPHKSLHIPAEKRAEAVKGLGRRKTGHLKRPRKSLVGVMEALRMLVGVRSFGRWPLRVHFFEEDVWRVWERGGWKAKSGGGGVGELGDLKVEVVTDFGSPTAPQGAGVIGMGEEAENDPHDDDDGDDAQDENKHGIYALPLDYAPIKDYVAKSQEIWEFERQGSCVVCKEAMVAGRGLYAICPNTSCEAVGHLDCWSRCLLKQETRRMKIDEGDEILPVKGECPKCHGEVLWGDMMKELTLRIRGQAEVEKLLKKKKRRRAAKGKEKGKGKVADEKGNNAEGRNTKGNREVKTTPQRVVEDSEDSEFLDIACLQ
The following text describes a protein:
Function:
Essential for n-decane utilization.
Subcellular Localization:
Peroxisome.
Sequence:
MRLTLPRLNAAYIVGAARTPVGKFNGALKSVSAIDLGITAAKAAVQRSKVPADQIDEFLFGQVLTANSGQAPARQVVIKGGFPESVEATTINKVCSSGLKTVALAAQAIKAGDRNVIVAGGMESMSNTPYYSGRGLVFGNQKLEDSIVKDGLWDPYNNIHMGNCCENTNKRDGITREQQDEYAIESYRRANESIKNGAFKDEIVPVEIKTRKGTVTVSEDEEPKGANAEKLKGLKPVFDKQGSVTAGNASPINDGASAVVVASGTKAKELGTPVLAKIVSYADAATAPIDFTIAPSLAIPAALKKAGLTKDDIALWEINEAFSGVALANLMRLGIDKSKVNVKGGAVALGHPIGASGNRIFVTLVNALKEGEYGVAAICNGGGASTAIVIKKVSSVE
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MAPTVDPSVTSDASFSFASKSESPDLGLIPPPMAQQPSSYRQTVIRAGDEVEFFSGELDRHLTDLNGTTEEKRAQVFQLIDSYHAYSRKRADRLRERQPRKLTLRENEMDIDDNEIDDLAVNFDEEYRKAEEEAQTWDLLRRMLPLEYGQDETSQLKQHTKPSLQSRNQWWNDFMLSDSLAREQKVVLEWLQSSASQGPPVDDVVSHLQESAERGDILAHGWLHTRTKIKLQKSVNGYQGSLDPRASGFAESHLSSNTLVTQLDPDAITRQARKLETQDDFFERAIWLGCFEMLRRGFSMAEIRDWCSMRTELWRAASLTPLPLANPEDEDQPDFDPRSLVLWRRMCFSTARDGGTSDYDRAVYGLLAGDIASVEKVCETWDDLLFAHYNALLRTRFDSYLVKHGGDEAARIAQQFPAFNAVLHHGDPHSVGKRLVTLLETDLRTSNEATRPSKALQGAIIAHELGRYLTNQGLVLAKHANQRSKSNLIPPVDLQVPDDLTHPKYFNLSDHSSLRVLSHVLIIFTTLNRLSETRTISDAHQEAMENIIAAYISFLRLANLEEMIPLYCSKLHGQRVYEALSRNLIHILDNGTRRVQISIMNRLGISVSEFVKRQPEIFLSDVHDLLQPCEAKRKFKVLEDGPATLKYGRIVKPDFFGDDEAEEFDQEEGHILCSLEWLMLIDDLFVETCTYVIRAYKYFLKRTRLRAARALSQRVPGREIIRRKTGILVGGEGDDGGVEWFADFAASELPEELLALYAGDKEAVITQVRNMWELECLVKALDSMETLSSLAGLAREDSTNSRELWQHTNKEVRAAKAYMQPVLKGWLLETIQPDPDFQALREAYIPETVLALVSSLHFAGATLSRDYFLECMELAAVVAEKASAVSQEFVKSGRIKELVEAYASCSKALAIFASEKKAISKETKKIREHGWSRELWSVKPQ
The following text describes a protein:
Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
GPSAQILLGLSLHKERKSGVGGGLPGWAEAKAGDGKRGQGWGISSEQGVLQSPRARPHIHPHLQLRATHTHTHTHTHTHTHTPLPRRPHARSGLGRGVGGQQIPGEGSTAPAARPGPSAHPPPRWRRRRLPQGDGDPGARGAGAALRKKGAQPARRGPRARRGGSGPRCPRPAPAPALRLPGPPRCGGRGAGRGAAYIRRGAGAALLSLAAATRVGAAGAGSQRNSSGRSKNMADKPDMGEIASFDKAKLKKTETQEKNTLPTKETIEQEKRSEIS
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and cell cycle progression.
Subcellular Localization:
Nucleus.
Sequence:
MDRSSASRPDLYLIADNDSVYEQDLLRNPGTIKPWLAYIEYKQQNGTLYEQAFVGRPLDALIISILNDFQVMERACKQLPRSYKLWKMYLEFRTKHLKNRNAIKYRAEFQKVNTLFERALILLNKMPRIWEMYLTFMLQQPLVTQTRRTFDRALRALPVTQHNRIWKLYKTFARSASGQTAVKIWARYMQIHPENAEEYINLLVEMGHYTDAIKRYMEILDNPRFQSREGKSNFQLWTEMVDLLVSKAKKIETGPQTGIDVDAILRSGIDRFADQRGKLWAGLATYWITKGNFEKARDVFEEGITTVMTVRDFTLIFDSYVEFEESIIGSLMEAAAVRADNGKADEEADFDLDLRMLRFEQLMDRRPFLVNDVLLRQNPNNVIEWEKRVALWGDNNVEIVNTYTAAIAAINPKKAVGKFSELWVNYAKFYERGGDLDTARIIFEKAVKVPFKSVNELAETWCEWAEMELRSENFDKAVEIMAKATQAPKKSTVDYFDETLSPQQRIHKSWKLWSFYVDLVESVSSIEETKKVYERIFELRIATPQTVVNYANLLEEHKYFEESFKVYERGLDLFTYPVAFELWNLYLTKAVDRKIGIERLRDLFEQALDGCPPKFARPLYLMYGNLEEERGLARHAMRIYERATRAVSDEDRFEMFEFYITKSASNFGLPSTRPIYERAIAALPDHEAKEMCLKFAEMERRLGEIDRARAIYGHASQFCDPRTNAPFWQKWEAFEVQHGNEDTFKEMLRIKRSVQAQYNTDVNFIASQAIARSQQRAPEGEEATAAAEREMDTETTDAMAALERQARAPIGFVAASTGPEGGNRAPPAGQGPVAAPANPDAIDLDDDMEAD
The following text describes a protein:
Function:
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.
Sequence:
MASQPNNVGILAMEIHFPPTRLVLEELEAHDEVSKGAYTTDPGQDCMGFVIEDEDVVSMSMTAVTLSFGEEHGNTDIEGVDSHNSSYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAKGPARATGGAAAIAMLVGPDAPIVLESKIRASHMSHVYDIYKPILDSEDPVVDSEISQTCYLKALDSCYKGLCNKYEKVEGEQFSIDNAAYFAFHSPYNKLVQKSFGRLLYNDFLRNASSIDESARQILAPFESLTGDESYQSRDLDEASQQVAKPFYDEKVEPTTLIPKQVGNMYTASLYAAFASLLHNKHDTLAGQRVIMFSYGGGSTATMFSLKLNEGQHPFSLSNIATVMNVAERLQKRYEYTPPEFDIFVGLYEARREFGIKNDYWCEMPGSILPPGAYYFRGVDSEYRRAYGKKTPEIEQEIEEIILE
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MPLGRLLLRTSTVNKIVSRNAYRATKPDVSKPNMLRVGLAFGSTVFLWALLFKQHSNDVQEYKRRNGLE
The following text describes a protein:
Function:
Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.
Sequence:
VAIVDNRKEAGENAQRDLAKSFGRDNVIFLQCDVTNEEEFENAFIEAINKFGKLNIVVNSAGVAELPNWRKVYAINTMAVYSGNLLGLKHMDKSRGWEGGHIVNVASITGFMACPPVPSYASAKAAVISFTRAFGSDIFFKRTGVTVNCICPDAMDTPLLKGLLDACVHGGPEAIAVGKYFQESILE
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.
Sequence:
MHEITLLQGLSLAALVFVLGIDFWLEALFLFRPIIVCTLTGAILGDIQTGLITGGLTELAFAGLTPAGGVQPPNPIMAGLMTTVIAWSTGVDAKTAIGLGLPFSLLMQYVILFFYSAFSLFMTKADKCAKEADTAAFSRLNWTTMLIVASAYAVIAFLCTYLAQGAMQALVKAMPAWLTHGFEVAGGILPAVGFGLLLRVMFKAQYIPYLIAGFLFVCYIQVSNLLPVAVLGAGFAVYEFFNAKSRQQAQPQPVASKNEEEDYSNGI
The following text describes a protein:
Function:
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MLRLYYQAFSKLIKVDHLAMTPHQYWIAAGKGMERPYTGEYWFNQEVGTYHCKHCENQLFSFDTKYKSTTGYAQFWNHIPNSVKLEESNVKEERDLCCAGCDSFVGKVSFDGPPPTFIKYSINSAALNFKLKPFQEDPYFRKIARKEQQAQRSKKVEHNYLESNKNL
The following text describes a protein:
Function:
May function as a sodium/calcium exchanger (NCX) and participate in the maintenance of calcium homeostasis. May play a role abiotic stress responses.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNHVRSSSTAETCAQTYSFLPCTTTALGNLFLVLAYGILNYKVRVSFLTAGSDLLLETIGPGYVGHGHIVTLLLPMLGALPDALLVLASGLSGSGEKAQNQVLVGMGLLAGSTIFLLTVVWGTCVFAGKCDIGPNGAAIDLEDNKGWFSFTGSGISTDDETSWTARIMAICVIPFAIALFPKMLRTQPGHRLPILLASIVSFLLALSYCMFQIFLPWIQRRRLAFAKHRHVISGILKHAQMQALGRLLNDDGTPNENVIRKLFYKIDNDGSRDLSRAELHALIIGINFEEIDFDKNDVVDKIMDDFDTSGNDTVDEEEFLAGMKIWINEAKRKVQASGAYANKFINDYHESQQAVLILQRTREEHDQLAVSDEEVEPVENPGRMIVKAVGLMLVGAAIPAAFADPLVDAIYSLSKATHVSSFFVSFVVLPLVNNSSEVVSAVRSMRKKKRRSASLALSEVYCVVTVNNLMCLGMFLALVYARDITWDFSSELLIILLVCIVMGLFTSFRTNFPLWTCLVAYLLYPLSLVLVHILDSVFHWS
The following text describes a protein:
Function:
Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation.
Subcellular Localization:
Peroxisome membrane. Cell projection, cilium. Note=Associates with the peroxisomal membrane; it is unclear whether it is embedded or just associated with the peroxisomal membrane. Localizes to ciliary rootlet.
Sequence:
MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRCKFTSTPFTLKDILLGDREISAGISSYQLLNYEDESDVSLYGRRSNHIVNDVGINVTGSDSIAVKASFGVVTKHEVEVSTLLKEITARKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGREKAIVFPAHTTIAFSVFELFIYLDGAFDICVTSVSKGGFEREETTTFAMFYRLRNILFERNRRVMDAISRSQLYLDDLFSDFYDKPLSMTDISLKEGTHIRVNLLNHNIPKGPCILCGMGNLKRETVYGCFQCSVDGVKYVRLHAVPCFDIWHKRMK
The following text describes a protein:
Function:
Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLRDNIIDSKLISTQPKYLWFLTLTYSMVIVLANWFDPRLINIFGLNTDAGTLIFPLTFLLSDLITEVYGYKHARRAIWCGFLFNALFIIYGQVIIHMPSPNYPTNNTVFDTLLATNVRIILASAISYLSSEPLNSFVMAKLKIKTKGRYLGIRFVLSTIVASGTDSTIFSIIAFYGVMSDSNLIMLALTMWFIKVFIELIGLPISIRLTKKLKKMEQLDIYDKQTNFNILSLDTNYTARDNEFGQIKDKSL
The following text describes a protein:
Function:
May function in nuclear protein import as nuclear transport receptor.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAAGSAGLPATISDKQEFYQLLKNLINPSCMVRRQAEEVYENIPGLCKTTFLLDAVRNRRAGYEVRQMAAALLRRLLSSGFEEVYPNLPSEVQRDVKIELILAVKLETHASMRKKLCDIFAVLARNLIDENGTNHWPEGLKFLIDSIHSKNVVLWEVALHVFWHFPGIFGNQDRHDLDIIKRLLDQCIQDQEHPAIRTLSARAAAAFVLANENNIALFKDFADLLPGILQAVNDSCYQDDDSVLESLVEIADTVPKYLGPYLEDTLQLSLKLCGDSRLSNLQRQLALEVIVTLSETATPMLKKHTNIIAQAVPHILAMMVDLQDDDDWVNADEMEEDDFDSNAVAAESALDRLACGLGGKVVLPMTKEHIMQMLQSHDWKCRHAGLMALSAIGEGCHQQMEPILDETVNSVLLFLQDPHPRVRAAACTTLGQMATDFAPSFQKKFHEIVITALLRTMENQGNQRVQSQAASALVIFIEDCPKSLLILYLENMVKSLQSILVIKLQELIRNGTKLALEQLVTTIASVADVIEENFIPYYDIFMPSLKHVVELAVQKELKLLRGKTIECISHVGLAVGKEKFMQDASNVMQILLKTQSDLNNMEEDDPQTSYMVSAWARMCKILGKDFEQYLPLVIEPLIKTASAKPDVALLDTQDVENMSDDEGWQFVNLGDQQSFGIKTSGLEAKATACQMLVYYAKELREGFVEYTEQVVKMMVPLLKFYFHDNVRMAAAEAMPFLLECARIRGSEYLSQMWQFICDPLIKAIGTEPDTDVLSEIMNSFAKSIEVMGDGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEENYDQQVEMSLQDEDECDVYILTKVSDILHSLFSTYKEKILPWFEQLLPLIVNLICSSRPWPDRQWGLCIFDDIIEHCSPTSFKYVEYFRWPMLLNMRDNNPEVRQAAAYGLGVMAQFGGDDYRSLCSEAVPLLVKVIKCANSKTKKNVIATENCISAIGKIMKFKPNCVNVDEVLPHWLSWLPLHEDKEEAIQTLNFLCDLIESNHPVVIGPNNSNLPKIISIIAEGKINETISLEDPCAKRLANVVRQIQTSEELWLECTSQLDDEQQEALQELLSSA
The following text describes a protein:
Function:
May play a role in mediating maternal-conceptus interactions in the immediate preimplantation period. Does not seem to have proteinase inhibitory activity (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MRQLCLSSALLFLLVILVDSTPLNIHHIQDEGVETSHRRGPEKRSVIDVVTSIIDGVATGTKIVKNGAGLLTGLAEIITKAIKGQVMISRIQFDNHTQEELPTLNIEYSTLSEENKGVETSHRKGPEKRSVIDVVTSIIDGVATGTKIVTKGASILTGLAEIINKAIRGQVMISRIQFNNHTLEEFPKLNIEYSTLSEDNTGVETSRRRGPEKRSVIDVVTSIIDGVATGTKIVKKGTSILTGLAEIINKAIKGQVMISGIQFNNHTLEEYQTLKIEYSALNEENKAASKPALCLEPKVTGGCNAVMTRYFYNAQNGLCEQFVYDGCEGNGNNFEKLEDCMKTCSQEAGSL
The following text describes a protein:
Function:
RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, P-body. Cytoplasmic granule. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3 (By similarity).
Domain:
Binds RNA through its KH domains.
Sequence:
MPSSLFADLERNGSGGGGGGGGGGGGGGSGGGETLDDQRALQLALDQLSLLGLDSDEGASLYDSEPRKKSVNMTECVPVPSSEHVAEIVGRQGGSGRDGDRRGFSISPTPSLEPWLPGCKIKALRAKTNTYIKTPVRGEEPVFVVTGRKEDVAMARREIISAAEHFSMIRASRNKNTALNGAVPGPPNLPGQTTIQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEAHIALRTGGIIELTDENDFHANGTDVGFDLHHGSGGSGPGSLWSKPTPSITPTPGRKPFSSYRNDSSSSLGSASTDSYFGGGTSGSAAATSRLADYSPPSPALSFAHNGNNNNNGNGYTYTAGEASVPSPDGGPELQPTFDPAPAPPPGTPLLWAQFERSPGGGSAAPVSSSCSSSASSSASSSSVVFPGGGASSTPSNANLGLLVHRRLHPGTSCPRLSPPLHMATGAGEHHLARRVRSDPGGGGLAYAAYANGLGTQLPGLPSSDTSGSSSSSSSSSSSSSSSSGLRRKGSRDCSVCFESEVIAALVPCGHNLFCMECANRICEKSEPECPVCHTAVTQAIRIFS
The following text describes a protein:
Function:
May be involved in cell wall biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MTSLILLLLLLLSSLLSPSSPVEFRDSLSDLSQQSILHCSTLTSTDKLLCEFAGAIDDQGNPATRTPTVQSSSCKFKEDGAYNAYYPYATSPSQELTTILEKYFSMHQRCVAKDLATLANAYSSGGRPLCQYVIWGASGDGLGNRLMSLMSAFLYSILSARVLLIDYPEWRELFCEPFLGSTISIPQGAAFDRGIGAWNVEFLDAKCGSPLSSVNNGGCNNTIVKLSLDHDTPLREYDFVMCPLGYSRLRNVPFVTIRECNQYLVPGFYANPVLTPLMDLLFPERNVFHVLSRYLLSPSDPMWHSIRDDTDVQASRRIGIQIREFQFEKYTSEYDDNIVRCLWERGGILPRRFRKGVCEGEYLAIHVATLEKGHVLKVNETMKIIEEETGVEARVSRQAVDGREAHDAAHQEEALIDIWVLSMSHVLITSIYSTFGYVASALSGVAANFIDKREGESCKVSNGVEPCFHAAPKLLVCSDDELMRYTAFDLAVNSSWVRPCADRIVLGWTLAKGTSYPK
The following text describes a protein:
Function:
Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSYGDAIPEVKAILEAKNEEELVTFTSRWSAEERKELRTQFQDTTGLEFIAFLKKCIKNGPYEDVMALGWDCNISARVNVIKKAMKNVNDFRAIHDVVLIATPDERLKLAQAYKEKTGNDLLQDFVDQIPLTSAASYLCHLAIRENRTPRGSVASDAEVLKHNLIDADEPDHEAVVRLIITSTADEYKEINHRFEVLTGKSVQEAIETRYADKENARGLCIAHYYNLAPARAVAYAFHSAVETQNDDMAYEQAARITGLFHDLHKFAWVHYACWGVMRDDILSRFQSKEANKVNFRDACLMFWKLAK
The following text describes a protein:
Function:
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
Domain:
The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MPTETLRYGDHKLQTVTISTVSDNLNAGYWVILIHGGAWRDPTQTAASYVAPAESILTTSPTYTSTTLPHIAAFASIEYRLSAHPSYPQNPDHLDSTEYRNAKHPDHIRDVQAALALLQRKYGFGSKYILVGHSAGATLAFQSVMGTFRDSAAAVASPPVAILGMAGIYDLRLLRDTHRDISAYQEFIEGAFGSDEAVWDAASPAFVKGSQGVEGGWTSGRLAVLAHSAEDGLVDAAQQKAMQAALSRWEDNTPQGSGQRRVEMLSLKDDHDDAWMKGDELARAIAHTLAELQKQ
The following text describes a protein:
Function:
Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MVMDTLHFIVSRLNKAPFNKALRAVDFDEQSPDRHLQILNDVLSSLNPEIKANILVASRDQVVEQMVVFLLKHKCEQAPSSEDDRHEWIARLEKGDKADIYPVLQWVLLNYDKISKRTYLANFLVPIDVPSEYADNNSELADLMDAFQELQTEFVDVHQQYETMSAKSDRPVTAVLDDIKKLQIEKQQLTDRLQREKDQTSSNPKFQRLLEEASNMRQAQNDEIRLTEQKQKQLLCMKAANQRLRQVQHLSDILGGAKDDNRSFDNMLVELENESQKAIEHLDTSIAAQRHRLELEVLSAKRECNSPLKTEEEIEEIEELGMQLEDDLYHRHEELKRLNRYDDNLSKLSTFQQHVTVIKSKLQAKKEALDWKAIEKEQLISANNKLHKSIAELEDQTQEVKRPGGSAMTKREFEQFQHDLAENTTLYDEAKQDIITMQNDIEYLTKEEATLKNQHYNLEEFLRQREEVAGVADFADVLGHLEATGKQTAVLNDLKAQTLEEISNMVQKIAFTLEEKKKDLEPKVQELKNARTNFQEFQTSYNKKKANHETQFIEIMNDITALERECSRLQEKWHERERSYHFLCAKDEILASNTQCLELEEAWRNGHDHDTHLLPGACSLKELYENKIQEQQRLVSGLREHHLDLKARQEYNAQQKATFTSLMKLLELNAKSSNDENVQ
The following text describes a protein:
Function:
Junctional adhesion protein that mediates heterotypic cell-cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam3b on neighboring myocytes.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, tight junction.
Sequence:
MLVCVSLLILIHSVPVSPVTVSSRNPKVEVHEFSDAELSCEFKTEKDTNPRIEWKRKDKEKDVSFVYYGERFVGPFQDRADIEGATVRLRRVTQADAGEYRCEVSAPSDSISLGETNVTLRVLVPPQTPSCDVPSSALTGSQVELRCRDRHSIPPAVYTWYKDNRALPIRHPNATYTVNEFTGVLIPQSHYNPGTVCQHCMYHPNYHIPNTQLTTTFQTHDLNVAAVVSAVVLVCVILFLCAFGVCLAHRQGYFSRHRGRSFWIPHCHGVTHISSQNLNPSEHTQHSGYSHPPKEPQDFKHTQSFML
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Sequence:
MGKPQGKRTEFPPSLPACFSALAPPFRLVFFGFAFVSEQPLFLHSPPTALPSRLQQRGAMAVGGHPSARLQDDATCSICLDYFQDPVMIIDCGHNYCRACISQCQGERSLCPRCRIPFPSDNLLPNRDLRNLVEAIRQLSLQPLEKAARPKPAGGGPKMCEKHQEAAKLFCQEDKAFLCLICRESRAHKAHTALPIEEAAQEYRDQIQTFLQKLAKERDELQRAVVYNRHHYQQLKSIVESAKQRIGPNFPKKESQTLMPLLNTCEANLQIVTEASNDLSCLNTLITDIEEKSKQSSFGLLQGIGDLLNRCEQETRRPRRELKTILESIAENMDLVNTRLDQYAENTPKKKWIKENVTLDAKTAHPRYFVSDDRKSVHWAKSRQDLPYSSKRFEFARCVLGKKGFTSGKHYWIVDVEDGDYWAVGVAQESVDRDGELDFEPDEGIWAMARYDDQYKALTSPPTLLDLDYDPKEIQVSLNYDAGIVHFYDEDKKPLYSFRSIDFEGEKVFPFFRIGDSSTSLYLL
The following text describes a protein:
Function:
Inactive serine protease that plays a role in germ-band retraction and dorsal closure morphogenesis in embryogenesis; contributes to amnioserosa attachment and epithelial apico-basal polarity by regulating the localization of laminin LanA on the apical side of the amnioserosa epithelium. Contributes to epithelial morphogenesis probably by regulating the bsk/JNK pathway, as part of a negative-feedback loop, and by modulating the cross-talk between the Egfr, bsk/JNK and dpp signal transduction pathways. In larval development, antagonizes the morphogenetic movements controlled by the bsk/JNK signaling including male genitalia formation and thorax development.
Subcellular Localization:
Secreted.
Domain:
The CLIP domain consists of 37-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.
Sequence:
MSASHFREQLALCITLAVLAAASGDYRANMFLNGQYQNGIKDQKENNLLVNPSTNVFLNHAIISRQASPFQGPTYLPPKEFLKCAPGQQCVRSGQCLNGYFAQQLPKIQNCDPETTVCCTYRPPPTTTTTTTTSVPVANCAYDSDCVTPDNCRNGEISAINYVKKQGPNRCPAPNICCRIPSTTLTEDGYIFNLPEKTFPLPTKPAVLAMPSTQAPFRPQPTTAVPASRPTIEYLPPSTTQHPSYEKVQTSRRPVYLPPSPATESASSLIPKIRPRPEPRPQPTRRPTNEYLPPAAANEIPRFEPDRAPQPSNQKPIYRGEDQLSPQIFPTPQPANVPKHFAKCASALVCTSENFCNAIGVLSETPVELSPMEAAFRVPLTDCLQTENGSPGKCCRDPNYVDPWPVNLAGVCATRNKRTKPTGVKDLDANFAEIPWQAMILRESSKTLICGGAIIGDQFVLSSASCVNGLPVTDIRVKAGEWELGSTNEPLPFQLTGVKTVDVHPDYDPSTNSHDLAIIRLERRLEFASHIQPICISDEDPKDSEQCFTSGWGKQALSIHEEGALMHVTDTLPQARSECSADSSSVCSATKFDSCQFDVGSALACGSGSSVRLKGIFAGENSCGEGQTVRFAKPDIKWINTAFAENNKPLLLKRF
The following text describes a protein:
Function:
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably responsible for energy coupling to the transport system.
Sequence:
MLSVEELQFLYHNRKILNEIAFSIDEGEVVAILGPNGVGKTTLLKCLNRILHPKEGAVHIDGENLFDLGTMEIARRIGYVPQRVETGRLTAFDAVLLGRRPHIKWNITEKDLKIVDSVFRLLSMENLRLSYIDEMSGGELQKVAVARSLVQEPKVLLLDEPTSSLDLKNQVEILAIIRKIVLEHGIAAVMTMHDLNQALRYADRFILLKGGKIHAHGGVEIITPQVIEEVYGLPVVIGEVSGIRCVVPGSPAWDCSTGYVASR
The following text describes a protein:
Function:
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaB is not essential for flagellar synthesis and motility.
Subcellular Localization:
Secreted. Bacterial flagellum.
Sequence:
MAITVNTNVTSLKAQKNLNTSASDLATSMERLSSGLRINSAKDDAAGLAISNRLNSQVRGLEVGMRNANDAISIAQIAEGAMQEQTNMLQRMRDLTVQSENGANSSADLSALKAEMDQLANEIDEIGKTTAFGTTKLLAGGFSAGKNFQVGAQDGEDIKVTVKASNKSSLSVGSLGNTTSAARASSLKKIDAAIKTIDAQRADLGAIQNRLAHNISNSANTQANVADAKSRIVDVDFAKETSQMTKNQVLQQTGSAMLAQANQLPQVALSLL
The following text describes a protein:
Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Subcellular Localization:
Nucleus.
Sequence:
MGERQYQEKLKRMRHQHEIENQLLMAQFNYQTSNLQHQHQLQQHLNITNEINNVIFVWEFLFVQRLKHVISKQRERVAEQMAALDQRSELINSVRNKEKNREKTGAVASNAVKQHLQKFVKCRQKFKDSHPSMERLLHISPGGNYLACFTYVVTHRSPLQWTPSLEGKNGGHEVPAHYSSLLHTQYDFPLRKTASEPNLKLKSRLKQKLLEDRVERSSPLMPRRGDIKADLANRIKKKINIENVNEQRNSHNSAPNSGPSSPPNSSNDIKQSTPHMQTEFYNQQTDYYEESNSSGNHDLYSSPSLPNISIGLTNKKSTVYFVITYRNLSFEQDRSMLVVSEELSKRGTRGSSLSDPMIQTMVIIGSLTHINILIIKSLRHHLSKLHEIDLTQAVQANLLPPHKTVLHGTYHLCTQASTPPGPIRHSQTTRQHKALSRTQSAPTAASQLQLHILQLKRRQKMLQQQQKKGLMHGVAEVDSHSYSILPTHLETEDGEQWVKRNQYSHAQSTPNQPFIPSNKIASTQAQLVASKPEIPAVARVAIVSVYKLNNCSSFYNKPTQEEGGIAGTRHLPPQSTIPIHSQPSSLSDQNKPRLLRTQSSPATSFIKKLPHFKKYRYTTGIAYSPVMLKHGCACRDDHTEHAGRLRAIWERLTKSKLVNDPSCGGTSGKSSCELLEARKATTDELQLVHTQEHTLRYGTTSLARKELGEKLLCQELTSKFIVLPCGGVGVDNGIDIDTVWNELDTINAARMAVGCTVDITLEVAQNRLKNGFALVRPPGHHAQKDLAMAFCYFNSVAVAARKLQHECPDTVRRVLIVDWDVHHCNGTQNIFFDDPSVLVISIHRYDSGNFFPGTGAINECGRGGGLGYNVNIGFSGGLDPPMEDADYLAVFRTIVLPIARQFDPHFVLVSCGFSAANGHPSTLGGYKLTPNCYGLLTRLLSEVAGGKIVLVLEGGFELEPLCDCTEACVRTLLGNHEYSNLSMESMERRPSKNAIDTIKNVITIQEKHW