lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MILDNGSYAIKSDRTGDAETPNALIRGRDKTVYVGQDLTKCKDYASLVFKRPSEKGQLINWDIQKAVWDNLFYNPQTGVDTDSSLLLTQYPLTLPQVSANIDQVVFEEYGFEQYHRTEAANLVAWSSGQCLDACLVVDAGFNATHVTPVLFGQVHEPGIRRVNVGGKTMTNLLKETVSFRHYNMMDETYIINRVKEKVCFVSQDFDKDLDLAKKTKSLQVEYALPDYKTTKLGYVVDRKQHDISELQTLKLGNERFTMPEILFDPSIIDLQQSGLCETIAESIQASPKEFRSLLCSNIVIVGGCAKLPGFQSRLEKDLRPLIPSEYHMKTRLDDKPDFTTLQGGKVLVDQPGFSNLCVTKQEYDEYGWRLCRQRFQGETFDEDTESA
The following text describes a protein:
Function:
Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEVLPKALEVDERSPESKDLLPSQTASSLCISSRSESVWTTTPKSNWEIYHKPIIIMSVGAAILLFGVAITCVAYILEEKHKVVQVLRMIGPAFLSLGLMMLVCGLVWVPIIKKKQKQRQKSNFFQSLKFFLLNR
The following text describes a protein:
Function:
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1D-myo-inositol 3-phosphate in a NAD-dependent manner. Plays a key role in oxidative stress resistance as its product is the precursor of the protective antioxidant mycothiol (MSH or AcCys-GlcN-Ins).
Sequence:
MSTSTIRVAIAGVGNCATSLIQGVEYYRNADPSETVPGLMHVKFGDYHVGDIEFVAAFDVDAEKVGIDLADATEASQNCTIKIADVPQTGINVLRGPTLDGLGDHYRATIDESTAEPVDVVQALIDAKADVLVSYLPVGSEEADKFYAQAAIDAGCAFVNALPVFIASDPEWAKKFTDAGIPIVGDDIKSQIGATITHRVLARLFEERGVRVDRTMQLNVGGNMDFKNMLDRNRLESKKVSKTQAVTSNIPDGPLSGKVEDRNVHIGPSDHVQWLDDRKWAYVRLEGTAFGGVPLNLEYKLEVWDSPNSAGIIIDAVRAAKIALDRGIGGPIMPASSYLMKSPPEQLPDDVARERLEAFIIEA
The following text describes a protein:
Function:
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
Sequence:
MNTYKNSLNHFLNLVDCLEKIPNVGKKSAFKMAYHLGLENPYLALKITHALENALENLKTCSSCNALSESEVCEICSDESRQNSQLCMVLHPRDVFILEDLKDFLGRYYVLNSIEEVDFNALEKRLIEENIKEIIFAFPPTLANDSLMLYIEDKLQHFHLTFTKIAQGVPTGVNFENIDSVSLSRAFNSRIKA
The following text describes a protein:
Function:
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MQKSLITTPIYYVNDIPHIGHAYTTLIADTLKKYYTLQGEEVFFLTGTDEHGQKIEQSARLRNQSPKAYADSISTIFKDQWDFFNLDYDGFIRTTDSEHQKCVQNAFEIMFEKGDIYKGAYSGYYCVSCESYCAISKADNTNDKVLCPDCLRETTLLEEESYFFRLSAYEKPLLDFYAKNPEAILPVYRKNEVTSFIEQGLLDLSITRTSFEWGIPLPKKMNDPKHVVYVWLDALLNYASALGYLNDLDNKMAHFECARHIVGKDILRFHAIYWPAFLMSLNLPLFKQLCVHGWWTIEGVKMSKSLGNVLDAQKIAMEYGIEELRYFLLREVPFGQDGDFSKKALIERINANLNNDLGNLLNRLLGMAKKYFNHSLKSTKITAYYSKELEKVHQILDNANSFVPKMQLHKALEELFNVYDFLNKLIAKEEPWVLHKNNESEKLEALLSLIANALLQSSFLLYAFMPKSAVKLANAFNTEITPDNYERFFKAKKLQDMILQDTEPLFSKMEKIEKTEKAGEASPEKNEKEKKDAKEKAPLKQENYIGIEDFKKVEIKVGLIKEAQRIEKSNKLLRLKVDLGEGRLRQIISGIALDYEPESLVGQMVCVVANLKPAKLMGEMSEGMILAVRDSDNLALISPTREKIAGSLIS
The following text describes a protein:
Function:
P granule component, which acts redundantly with P granule component meg-2 to promote P granule segregation during embryogenesis, and germ cell proliferation and differentiation in larval stages. In its phosphorylated form, and together with meg-2, promotes the disassembly of zygotic P granules in the anterior cytoplasm of pre-gastrulation embryos. In its dephosphorylated form, and together with meg-2, promotes the assembly and accumulation of zygotic P granules in the posterior cytoplasm of pre-gastrulation embryos. May function with the nanos family members nos-2 and nos-3 to promote germ cell proliferation during larval development. Required for fertility.
Subcellular Localization:
Cytoplasmic granule. Note=Localizes to P granules in embryogenesis. Localization to P granules may depend on mes-1.
Sequence:
MDNRGHFSSNGNFPPQGYHRREQSQEGMRIGNHHGPFSSGNMRSIGGSAQNQQQRHWTNMLNGSNNVENSWVCFSGNTSLADDPNVLSNFSALAQQRVNHFDTIVQERDNRNASFLNGSAVGNNLNTSFSVFGNLRGGDQDHRVLSDHTGIYTGLGSTGQNAVGTGIRLAADVANGNFLEQRAPTAMGHNQSYSALNQSLAPTLLDQYNQALLDQYNQSSQMAQGRGYPAPNIAYGLQNAGFPAPQIAHRPNTQNADPQAMNMNNRLRDHTFQMPHTNAQVPMSSLPGLFNLSMNHGSGNQQFQMNQSSSGPAPQLPNLSESFQMAQGSSQVTMSSRPAHSNTSMNHSSRNQYNHVDQRPSRPAPHLPTLTKEEEAFLETPDFEQFGRQLYNYLLPGILPNGAADTFSDAPKHQLLKLAKTLKPMLYDYWRKTMQMQNRGANINIIQWIIDFNAKFAALNSSVAKASNSSDVLNQTLPTAAEVSDVAREDASTSQPSKSRSMYIRPAASLDNTLETLDENLDSSQSHAGPVPAASTKPKTPSFEKMIRYSGIKKRSTMDMDNFVRMLDEKINFSPEPSTSSDIASSVKGYMSQSFLHQQDDEAPDCTKNVHSESDLKQAEPQESDKQSDKELPSNE
The following text describes a protein:
Function:
Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
Subcellular Localization:
Peroxisome.
Domain:
RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Sequence:
MQKMQCHLRRPLHSSSSFSSQAVMMTKPMQEHKKEYTAQQALFRPSGIVTSIPVPLAGSALLPYHVSSTLYQSKSLSSSEHNKANGGSPQEHIAMESSAEEVDCFKNTCLPSELSPCSQNDFKPTNGDIDMQSPSKLMSGSMIISNFSTAMVHTIVNETLESMTSFKATKPVDTNADYLTKTIKGKPVLSLCDQAAPQQNKASSKDMFAEHLSKSIIKHSLDKSKSVLPNIDKKPVSKEHMLVLGEESQLTLGETPKFLDFSDNSPQYCVPECKDSVGFGFSLEALPPCSMMTSQKSDLKGVMKDKVVTRHNLTNTAFEPLSFGQESSFRPSQTLSSAVLTCVDSLHVEDKQKIRDRNVIPDTPPSTPLVPSQTSSEWDIKKLTKQLKGELAKEFAPATPPSTPHNSSVGSLSENEQTTIEKEEFMLKLMRSLSEEVESSEGEEHPEMDVKSEHSGKKGQFADALATHIISLATEVAASHLDHEITQEFKVQNSHLTVPSQRSMLPALSHSDESIQTCSFASDMAAGVIAEAEKVANTRSCMLFGHERTICHVEGDRGKAEEKLDVEDIAHPREVETCVLSLPSCMPGLTYKYPSCESVTDEYAGHIIQVLKQEGGNSELIMDQYASRLAYRSVKSGVREAAKTVKVKCSLKLFPMHTSHVKTNKELLFSSKEHHQEVDKKRQRKKYGSHPCKYQTCDRTQDPCRNELSELYRFSASLASSITRDVKKQLTAPKVDLPKSSTDCCLFEKSECVDNRENVTGPEFSKSCQPLQNHGLCQNTSSLSGYSCGESAHTVEQYARKVVGDTLELSLGPAVFLNSETTTSPDRITYAEKLSPLINEACRYCDLKESHGCIRNSAQLFSKQGPCASAKPSSHSKLSSIRQKSRIFHLDVPQIHLNLDKRAVLAEKIVAEAIEKAERELSNTSLAADSGIGQDGISFAESLTTEIMTTAMTNAGHAVSSSKEVEDFQSTESLGSQQMNLSVGEDSTGSWSNLSFEDDHQDESSSFHHLSESSNGNSSSWSSLGLEGDLYENNLSFPTSDSDGPDDRESEQEDGAEGLQPSGKTLLIVNIDVEPGAVDPQLRVILQWLIPRRRKLENFIFSTLQRRSLSYFQSSYRREDGKWAMSCRL
The following text describes a protein:
Function:
Probable transcription regulator which binds to DNA, repressing genes involved in longevity and stress, while activating genes involved in reproduction, such as the vitellogenins. Associates with homeobox unc-62 to regulate gene expression, including repression of genes involved in innate immunity. Required for intestinal expression of vitellogenin genes. Negatively modulates longevity, probably independently of effects on vitellogenesis. Involved in lipid homeostasis, contributing to the reallocation of intestinal lipids to the germline and to the formation of the cuticle. Associates with transcriptional regulator pqm-1 at the daf-16 associated element within the promoters of stress-responsive genes to regulate expression.
Subcellular Localization:
Nucleus. Note=Localizes to the nucleus in an unc-62-dependent manner.
Sequence:
MDNLIKQLQMSVSSENVDRNFIEKCIEMNPCRRMLHEVLLERKDILRSRMNLVALYDTDEQSSEIEEILAQFENPTFPLEEVNTEKDEEWQPLERKYLDGINRIKEDTIMKQIQLDKDMEKALTNSEEVLRNHRDFRPIDEKDFSNIRQSISKRFEHSKNNIRGEAATKILVLRREIEQQGRKRRNFDKNTTDILQNWFHDHRQNPYPSDQEKAELAKQCNIKISQVNNWFGNQRIRTKQQALRMQEDERERAASMANEAQAIQNSLNSSTVASSSNMSTSGLINIPLVNPTMQSMVIPAVQPGLLGNPNAFLHQPHYFTAGGQMSLNDNGNGQQFFTDYETFGLAQSDTESFNQMGYLG
The following text describes a protein:
Function:
Putative oxophytodienoate reductase that may be involved in the biosynthesis or metabolism of oxylipin signaling molecules.
Sequence:
MEDTHLLTPYKMGQLNLAHRIVHAPVSRFRSYGSMPQPHNLLYYAQRATPGALLIAEASAVSYAALGRSKDDAANGPIHRQRPGPPGFLFGTNLTDYNSATDGVKATESGVNDRNNLSKWWFMSRLNESGNAGGAEESHYTLPSSLDAPGLWNQEQIEAWRPIVDAVHAKGALFFCQIWHNGRVFSTDNPVTPQVSYFGNTDDLAPAAPQRLETGEIVQIVEDFRVAARNAIKAGFDGVEIHAANGHLLHQFMKASVNDRTDEYGGSVENRCRITVDAMSAVAEEIGADRVGVRLSPFADHCREEGTDPEEVALHLIGVMNGLGVLYCHVIEPRCMREQHRGAPRAPQRPAPPAPVQKGVPRHVHCERRVRPGGRGQGGRRRLRRPGVVREIVPGQPRPAGEVQAEGGSERV
The following text describes a protein:
Function:
Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP.
Subcellular Localization:
Nucleus.
Sequence:
METGGGSSESPVEPKKGKSKIPRKAKESLLKQKSPAEFFAENKNIAGFDNPGKCLYTTVRELVENSLDSAESISELPFVEITIEEIGKSKFNSMIGLVDRERVDEELYDDYETAKAREKRLAKEARAQEMQAKNAALGKKVKEQPSAKGMKGRGEASFYRVTCKDNGKGMPHDDIPNMFGRVLSGTKYGLKQTRGKFGLGAKMALIWSKMSTGLPIEISSSMKNQNYISFCRLDIDIHRNVPHIHFHEKRKNDDRWHGAEIQVVIEGNWTTYRSKMLHYMRQMAVITPYAQFLFKFISDTSDKNVTINFARRTDVMPPVPLETKHHPSSVDLLLIKRLIAETSKQNLLQFLQHEFVNIGKAHAERLIGEMGPEFSPKMPIKSLTDQQIVRIHQLFRQAKFDDPTGDCLSPAGEYNLRLGIIKELHPDMVATYSSSAQVFEGHPFLVEAGVSVGGKDVKQGLNIFRFANRIPLLFEQGADVVTRTALKRINWASYKINQIQDKIGVFVSIVSTKIPFKGTGKEYIGDDITEIATAVKYAIQQCCIQLKSKIMKKMQAREQQERKRNLSKYIPDASGAVYDVLREMAQLHASKRKCFEEEDADILEKVSARLITKDTLTEKLAQHVEKVDYEMALEYATQSGVSEEPREDIYIQTLESENKFIDFHSPIFVFRLIS
The following text describes a protein:
Function:
Since only maltooligosaccharides up to a chain length of 6 glucose units are actively transported through the cytoplasmic membrane via the membrane-bound complex of three proteins, MalF, MalG, and MalK, longer maltooligosaccharides must first be degraded by the periplasmic alpha-amylase, the MalS protein.
Subcellular Localization:
Periplasm.
Sequence:
MKLAACFLTLLPGFAVAASWTSPGFPAFSEQGTGTFVSHAQLPKGTRPLTLNFDQQCWQPADAIKLNQMLSLQPCSNTPPQWRLFRDGEYTLQIDTRSGTPTLMISIQNAAEPVASLVRECPKWDGLPLTVDVSATFPEGAAVRDYYSQQIAIVKNGQIMLQPAATSNGLLLLERAETDTSAPFDWHNATVYFVLTDRFENGDPSNDQSYGRHKDGMAEIGTFHGGDLRGLTNKLDYLQQLGVNALWISAPFEQIHGWVGGGTKGDFPHYAYHGYYTQDWTNLDANMGNEADLRTLVDSAHQRGIRILFDVVMNHTGYATLADMQEYQFGALYLSGDEVKKSLGERWSDWKPAAGQTWHSFNDYINFSDKTGWDKWWGKNWIRTDIGDYDNPGFDDLTMSLAFLPDIKTESTTASGLPVFYKNKMDTHAKAIDGYTPRDYLTHWLSQWVRDYGIDGFRVDTAKHVELPAWQQLKTEASAALREWKKANPDKALDDKPFWMTGEAWGHGVMQSDYYRHGFDAMINFDYQEQAAKAVDCLAQMDTTWQQMAEKLQGFNVLSYLSSHDTRLFREGGDKAAELLLLAPGAVQIFYGDESSRPFGPTGSDPLQGTRSDMNWQDVSGKSAASVAHWQKISQFRARHPAIGAGKQTTLLLKQGYGFVREHGDDKVLVVWAGQQ
The following text describes a protein:
Function:
Catalyzes the NADH-dependent reduction of maleylacetate to beta-ketoadipate, a step in the degradation of gamma-hexachlorocyclohexane (gamma-HCH or lindane). Has an essential role in this assimilation pathway that allows S.japonicum UT26 to grow on gamma-HCH as the sole source of carbon and energy.
Sequence:
MQFVYDPLPYRVIFGAGSVRRVADELSHVGSRALVLSTPEQAGSAQELAATLGDKAVGLFSKAVMHVPVATVDAAAAVARELDADCTVAIGGGSTVGLAKALSLRLDLPSLVVPTTYAGSEVTPIWGLTEDGIKTTGRDKKVLPKVVVYDPDLTLSLPAEMSIASGLNAIAHAMEGLYAFDGNPIVSLMAEESIRALARSLPLIKADPTDAKARGDALYGCWLAGSVLGAASVALHHKLCHTLGGTFDMPHAQTHTAVLPHAIAYNAPSVPEAMERASRALGGGDPATKLYELAVGLGAEMSLAKLGMPKDGIAKAAALAVANPYPNPRPITEEGIVQLLSRAVEGLPPITA
The following text describes a protein:
Function:
Nucleobase-proton symporter that facilitates the uptake of nucleobases in the cells. Can transport adenine, guanine and uracil. Contributes to uracil import into plastids for plastidic uracil salvage which is essential for plant growth and development.
Subcellular Localization:
Plastid, chloroplast envelope. Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MVSNCLSLSLHLNLHPHKHNRHSLSSLRSRTKAKLYQHVSFTDSSHKSSYTSCVSTFDIQRKSSKHYELGKHSFSPILPGDNLVLSRSGVIRPRLSAMTGSEINDHGYDESQFDPSLTNDDLKPTTPSQRTFSWLDMSSLWIGLVVGVPTYYLAGSLVDLGMAWWQGIATVVTANLILLVPLVLTAQPGTLYGISFPVLARSSFGIRGAHIPTLLRALVGCGWYGIETWIGGEAIFLLLPGHIKKSALSHTLPWLGTSPLEFSCFIVFWLAQLCIVWRGMDGIRKLEKYSAPILISLTSCLLAWSYLKAGGFGHMLSLSSKLTSAQFWTLFFPSLTANISFWATLALNIPDFSRFAKSQTDQIIGQVGLPVFMGLFTFVGVAVTSSTSIIFGRVISNPIELLGQIGGLATTLLAIVGISLATLTTNIAANVVAPANALVNLNPKFFTFGRGAFLTAVLGIVFQPWRLLKSSESFVYTWLIGYSALLGPIGGIILVDYYLIKKMKLNIGDLYSLSPSGEYYFSKGYNVAAVVALVAGIIPVVPGFLHKISALSKISNGFVVVYDNALFFSFIIAGFVYWIIMSRLGRKQSSLSSSSHPLL
The following text describes a protein:
Function:
Counteracts the antiviral effects of host IFN-alpha/beta and key IFN-inducible proteins involved in viral RNA degradation suxh as host OAS1. Acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.
Sequence:
MDRDVTALVIKTWAIFFAALPVSILLSARDAAGEDIKCQIHSSVAGKPAATPGQNVVLNCTVAAGRRASRMDWLKHGQGVTEGVTYCLDARGAGLTCAVLQIVNASAKDAGVYVCEARGKAGWDRSQILLHVFGPPRINIPLTQPGPLRWPLGSRQYLACEVTGYPAPNITWLYNNMTVRPGRHDMWHGAYYLNALDHRRLTLNLFAVTRDNQGIYMCRASNGWGKEELVLNVTVIELPKLAVNSDSQFYVSHRGENSTLTCTVTGIRNGETITAHWRHGSSASRGRTRTQTLSGGRARLVLFLEDVTASDGGSYSCGISSKEGTHATTFLVVVGHGLPGIQATRPRIKTTAGSRCVLNCIVTLPPRTSVILSWNRNGSLMEWTSRGRQYLRDLSRAEKRTEPLVPLKSVSKLGNAISLGSLGDSSDSRLEFNLEIVNVTEEDKGWYACELNTTLGSNSSMIYLTVANVSAVGLLPKDSSNFSFAGVLGVIALCSISSCIAAFAVRYLIRRKRFIHLKGSISSKHLNNKFKYDVFLTFSSKDVDWVIRHLTPLLDKLCLEYCIHTRDFEIGKAISENIADSVYHSRKVISIMSYHYMASKYCRAELDVALYRSTEYDDSSLIVIRVDDIPKAKLPRALRNRTFIDYNDPEERRHWEKRLVKYLRAGTRCSYFMETAF
The following text describes a protein:
Function:
Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase. The catalytic activity regulates its dynamic association with the 40S subunit. In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSGQFDDALDDTTERFDGVQLQEKATSPPASKVNGTAKLTKIEIQDALFGAPIKDEPTATDAQWEEYYDDEESDDDDDFYCYEGGELKRNQQLNLNQSHTNAQTTSQKVSHYQPADVLFKKFTNRINVEKYEGPASLPNHAKNTLIETQRKADSDRLRSKDKQDRATAEQVMDPRTRMILFKLLNRAMITEINGCISTGKEANVYHATAASGRDYAIKIFKTSILTFKDRDKYVTGEYRFRHGYSKHNPRKMVRTWAEKEMRNLVRMKKCDLPVPEPILLRSHVLVMEFIGHDGWPAPKLKDVELSGVKARELYRAAVEMMWTMYNRCKLVHADLSEFNLLYHEGKIVIIDVSQSVEHEHPHALEFLRKDCTNVTDFFRKRDVSTMTVKELFDFITDRGIGAEQVEQRLEEISERIANRSFDEFTEQQKLDEAVFKQIFIPKTLHDVYDAERDAFDKSTDELVYKTITGLDVVEADQKQDGSDSDTETSSEQSEDEEGGKRASNGGVVVVRSKDETPEERKARKKAVKDEKAEKRKTKVKKHIKKRKEKIAGKK
The following text describes a protein:
Function:
Probable zinc protease.
Sequence:
MESHDDLHQLIFEGSFEHDNQLWHIKPLESFQRIRTHSDSDPLPWQAHPTGGLVVWRESSDHAPNPDEIVASSCAHDQLSFNSNPQHAVYHAPQPPSSSQQIQFNPPSSFSLASMTSFLDHLLGMPSYRPAQSPSADINFNQSSRLVPPPSNTKTRTLHRRQSMTNDITWLGNSTTSSNFINSIGSTMGCPIGSRVVFIGVAADCTYVSKYKTQDAARMAILNNVNSVSAIYQRTFNVSIGVVELNVQSPECPASPKADALWNVACPGSGTGGLDLNRRLSVFSDWRGKKGGGDGAGLWHLMSDCSSGSEVGVAWLGQLCEVESQTSNTGQVTSGTGVTAATTNEWQVMAHEIGHNFGAIHDCASGCGLSDACCPQSQSSCNSNGNYLMSPVATKNTTNFSPCSIGNICTTLHSTVNTSCLVTPGRRAVISLQQCGNGIVEPGEDCDPGQNTNSSCCDPRTCKFRAGAVCDPLNGPCCQSDCQFASSQQVCRPSANAECDQEERCSGSDVHCPDDKFAANGKDCGPSGMGLKCAAGMCTSRDEQCKAQGTMLSLTKACPVGATMDCKIACVDPTGRADCIVLSTNFVDGSECGYGGRCVGGNCKAGSIKDTAESWFKSNLAISIPIAIVAGLLGLMFLLMIFRCLRDCATRSSSRPQYAPPIAPVPRIIPTHPPPTQPPHPSQRNWIDPTVYNGPVRV
The following text describes a protein:
Function:
Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSRTSAGELDVLKVQLKTWERQFLEENGRSPIKEDIKAHPEIRRKYKEYTSLKKLLSKGNAAVTGQKHGSPSRATHPTPQKHIDAEIELGPTPQIYGKVVSLFEMHISPLKKVPVRQLDADSSETCISPDLHSQDVAQSELLTDISCQAKRQLDFSVTPHASPVKAVQPLLLNAPDLRFEAIPHARTKYGPNSPVKFDGDVTLTLSQTPLQAKLAQASEGYSPSPLIKRPAKPLSQLAKEYEDIVEELKEVDHAAAVRNLGGLLQQEEENTQEAEAAEPSATRSDRKRRKNKVRPALVTLEEEIPQGNLHEQLVKLRQKALDKFNGNDPNDSSDEEKKTSATSAKPAKARKRKYNTVSDNFRRLKLPTKNTRNGRWRRR
The following text describes a protein:
Function:
Axonemal protein which is implicated in axonemal and/or peri-axonemal structure assembly and regulates flagellum assembly and beating and therefore sperm motility.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSKTRFSMIHSPQKTNRTTPTSKSFPRCNKKNSGSPVGEEPNKMTETEIAQIGKPLRQNICVEMLRDGFPHSFKELFALLQRWDEEDDDPLKLQTLQLHLTRAEAAERSEKYDEAYENHMLMARFFTEDKWMKHHFLELALRSARKVIMDSGKREAEARSLVGQAYLEKGDLELAQEHLEVFYQLTAGRTWQDSNGRMQHSRSCEELQTVYTLMAQRSLQDQQYEQAIKMSRKAYTIAKESGDRALEGEAAYRLGLAYQSTGDQKIAMKFLSSYMEIALTLEDTDSLGRAHEAMAKCLESEGKITEAIELWEKYVETCKSSKHDQNLERAYMNLGHILKSQKRYGEARVYFERAFELVCLEGCPRRVQEAQVYVGITRALSTFPAYMKLIQDQNLDALLAWKDRREDRFSSAASSEPESTALSNTVVP
The following text describes a protein:
Function:
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
Sequence:
MPKKKEDSQKTLSEKEAKGLIAKLSDEIRHHQYLYYVKNDPKISDFDFDQLFRRLQDLEEEFPQFKDLASPTLVVGSDLDKDFEKFQHKLPVLSLINTYNDNELLEWVNKTDPEGLYSVEWKIDGASIVLYYENGILKNGVTRGSGGIGDDVTDNIRTIRNIPLRLPKPITVYLRGEVFMTFKDFEEFNALSSGKYANPRNLSAGSIKQKNSSDTAKRPLRIFTYDATFPNMEKKFKTHQEIFSKLEKLTFPVPPNTAFVSGSKIAKTIQEFKKQKDSLGFPTDGLVIKLNDISKRDALGYTSHSPRWARAYKFDAIMKESKIVDITYAVGRTGKITPRAEIEPISLAGTTVTFATLHNQDYIDELGVGIGAIVRVAKRGEIIPAVEEVVTPGKEVFKIPDRCPSCNTQTIKKESLVDLFCPNPDCPDRVKNGIIFYCQRKQMDIEGLGDKQIEFLYDHDYIKSIADLYDLKDQKEKLMEEEGFGEKSVNIILKGIEQSKQKDFRFLLPSLGLSELGHKVTELLIEHGIDSIDEILSIAKDQKKIESLLEIPGIGPSTIQAFQENFSDKRILKLIERLKKAGLKMKADPIQVADQQPFAGQSWCVTGSFENFQPRDKAMDLIVYYGGRKVSAVSSKTTHLLAGPGAGSKLEKANELGVSVYDEKQFLDLLKSLKIDFKNLI
The following text describes a protein:
Function:
Controls the rotational direction of flagella during chemotaxis.
Subcellular Localization:
Cell inner membrane. Cell membrane; Single-pass membrane protein.
Sequence:
MAENEAEGGAATEGAEAAPPKNKLKLIIMAVGLLAVLGGGAATWFFFFRHGDDEHHAEAAPPPKPPAFVEVPDMMVNLAGAPGERVQYLKLKIVLELKEEKQIEAIKPAMPRVTDIFQTYVRELRSSDLNGSAGIFRLKEELTKRVNAAVAPVQVSAVLFKEVVIQ
The following text describes a protein:
Function:
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).
Sequence:
MSVSSRGAASPAHRTAPTKWLFTKEEMKKTASIQEGMSREEELASRQMAAAFIQEMIDGLNNVKDPKMKIGHTGLCVAHTHMHRFYYLHSFKKYDYRDVGAACVFLAGKSQECPRKLSHVISVWRERKDRKQLTTETARNEAAQIIVLLESMILQTIAFDLNVHLPHIYVLDIMKKVDKKEHYRPLTSCAYYFATDVIAVTDWSLRYSAASMSIVIIHLMAAYANVRIERLFADFINEDSPWYAKFDETMTNEKLREMEVDFLVTYRNSCQFHHASKFNFREHRPMLENPDVRKLDRTRDARSHSPMVHHVPDSTVNVRPRAYVPRDELTVERLNKERGVEEERRKRERDRMAGKLDSSTSSEKRARIDPLANNFVSSSSSSNGKLAPPPIPPQLNFPPPPIVSSGYNHKNQINRKNHENNHTNSSVSPAFVPSARTFDVAPMLTPPTAPKLQSADNSDMDLEDGELE
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MCLGTDATLPLSLCGVPGPKAPPECDAGGGPNAMTIEGSGKFWERPMQTFLSVASSDIQHQQFRQFLYQVGKGPQEICGCLHALCQQWLKPKEWSKQQMLDLVILEQFLSILPPDMATWIRECGAETCSQAVALAEGFLLSQAEDKKPEGQAKNLPQSLLSICNGVEPIEGPVSFEDVAIHFSPEEWAFLDADQRALQAQIMEETCGIVASLADNWNFAQNMALVLHKKLCAGKNGGAFDFDFKLTHLRCQTDYKGKKTHKCQECGKSFAGRTILLVHQRVHTGEKPFKCPECGKCFSASSNFLVIHERVHIGEKPFKCQECGKCFSQNSTLATHWRVHTEEKPYKCQECGKWFAHKSSLLVHQRIHTGEKPYKCQECGKSFVHSSHLVTYQTLHTGEKPYKCQECGKCFAHTSHLVTHQTLHTREKPYECLECGKCFATNSSLGSHIRVHTGEKPYKCGEWPLGSEEQRLSTEASTSCQQQCLGTKGHPICSSHGCLGG
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAKKRKLSTPASVAKRNKKKLRGGIEKKGKPSQEAGSNVFETIWSRKKFDVLGKKQKKGETRRVGLSRSLAIEKRKDTLLQEYKKKGKGNTFVDRRFGENDDGLGEEDKAIMRFQKERQSQISRQSKFALRDDEDEEEEEILTHGGMALSNVDDYKDEDNDSMQDDDYLDGLSKEEVMALNFGGGSSSNDGGSEGQKPKSKKEIMEEIIAKSKFYKAQKAKEKEEDQDLEEKLDKDFTELVQSQALSSLFRPTRKDNLKSMLAKGSTKDKGSGKDKEEEEKPDDFEKIMKEMVFEMRGHATDRLKTDDELIKEERERLEEMEKKRKQRMLGEDTEDDSEESDEEAGKANKRQKKKKRREISGDDLGENFVLDDEEKKGTGWVDEVLARRDDEEADSDEEEGSDEDEDEDEDEDESEEGDDEGDSEDGEGSDEETREELLEKVRIALEKKKKREEDRAIAAAKRASEALQEQDALPFVIDAPQTLGTFLTLVDRRSNEELVVAIQRIRTCNAISLAADNRRKMQIFYNVLLQYFGSLAMEKPFRLSRLNLLCKPLIELSTETPYFAATCARQRLVQMHTQITDRLKVSDGSSCWPSLRTIMLLRFWSLIFPPSDLRHPVMTPAILFMSEVLCRCPITSGRDVAVGSFFCTLLLSVLKQARRFCPEALNFIMTLLVSALPSQADGKLDFARSVCPAFMVEIGLAEQWLVLKNSKKEIETPALDFVALMTAEESDPVFKTDSFRVGILRTLLQTLNGFISLYEDLMSFPEVFSPVLLVMKRLKQESVLPECLRVLHTQATEVIETKLAEHERLRQPLRMRIQKRMPIKQFNPKFEENYVQGRSYDPDRERAEKKKLVRKVKSEFKGAARELRKDNYFLMEEKAKEKLAAEEERKEKFGKAMAFLQEQESAFKSGQMGKGKGRRRK
The following text describes a protein:
Function:
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSEDPFLLEQTENILRRVLFGTESTIGGISFENIIEKEDMSAIISMNDLDQVSYLLHEKIAELVFHIPASSIEMDSSDALTMGKILNDSEFDHILSSKEGEAMMYCFKALNNTVTEENNTFLPDSAKEIVRKVQYSILSVLAALQCGFLSPKMNKKDCQKALVAILYRSLISQTLLSMFVEFLLHRQQISYVMRKVLDHLRLAVLLTPFDVCFKDANLFVLPYRVLLTLLSTAMKDKSRPVADVLVAHPDFLPEPDILAGREIQTHSYLGPFFAKTLPTDDSSISGAEKLFDVEEPQPKDVLKSVFYPPFHSKLSEIRGYLHKMCHQLMIPPKTRARTLDWFAVALQRNEKRSQIRAEYRKLADHGFLMSLLGVLYELSSKINLDIVNNNSRVKLNDLTRLKMDSATAEEYQASLPAGPSEEKFVTETFFLTIHAQHIGVQPVVDKIKQLKRSTYDICEKIKELEEEQKKISPSDTINQKIIENTLKQQRTHFKKFVQRTMCLECLVKDPNMLTLAMDFSTKQLQLLVKAINPNFGVDGKLADEAPPLFSAYPEIYVEDVLDTMSYSILHAGDNLHLGARMDLPQNLLLIICSTHLFKNPYIASKVVQMMMSISPLSGSPHTYVLWNAVINHPIATARLYPSILRFYSDIETTDFYEKFGVRRSMQMIMKQLFEIPVYRAVFNQIAKPTDSSFIKFANMVINDATFCLDESLAALKKIHDVEVLMEKQQEWEALTAEEKQHKEGIRDEASRHVKSWLIFAKDTLDMLVWMTADTAPAFVNDTLGDRFASMLNHNISQMLGKKCIELKVRDAESRFDWKPRAFAAQLIEIYLNLSSPQFAQYVARDERSYTPAMMEDVVNRLGVFNIVPFSQLESFKGLHEEAVRMYNAKASEEMELEDAPDEFKDPVMDTLMEEPVKLPSGNVMDRKHIVRHLLSSQTDPFNRQPLSEDQLEPMVDLKERIDEWKREKLGKAK
The following text describes a protein:
Function:
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA.
Subcellular Localization:
Nucleus.
Domain:
The CRC domain mediates DNA-binding. It contains two CXC subdomains (joined by a flexible linker) which are both required for efficient association with target DNA. Each CXC subdomain coordinates three Zn(2+) ions.
Sequence:
MDVVSPELNSLLPDEIMDTEAMDEDPPASHLTPPPQSAPESAQVPMETEVPEIISICPTTASMQAISTNAKSTTSSTTQLLLTPSSSSSTTTKNATPTLPKIPSLSVPPNHQLIINKVAADGKSPGGAVIKQEGQKLLVAGLSKTGQPIMLALPHAWNKPATSQGSGDAKSQPTQIKMVTAMGKPVIAVSSASQLVASSTPLQAQHLKTLQITKKPPVSTAGPMITKLIITKALNNKVLSSPGSVSPVVTGRVVSQSTPLTPPRTIAIGETISTVPQNAATNSKVAISPLKSPSKLTVVSVTSQSSNSPQKSMTLPLNVALGQQILTVQQSAVTSPAKAGSSQSTTQTVKPVQTVTVPTSQFKTIIPLTTPPNVQQIQVPGSRFHYVRLVTATTGSSTVQTGGSTNTNPSIQPAKPVMMNAAVRMSVPIVPAQTAKQVVPKPLSSAAQVVTTSQTPQRLIMPATHLPQIQPNLTNLPPGTVLAPAHGSGNVGYAVLPAPYVTQIPQPAFVTLTSSSTFSTATPSQAQARLSLNGLSTSEANSRPRKPCNCTRSQCLKLYCDCFANGEFCNNCNCVNCFNNLDHESERLKAIKACLDRNPVAFKPKIGKGKEGESDRRHSKGCNCKKSGCLKNYCECYEAKIMCSSICKCMGCKNFEESPERKTLMHLADAAEVRVQQQTAAKTKLSSQISDLLTRTTPAITSGGGKLPYTFVTKEVAEATCDCLLEQAEQAELTNQPQAMAERLILEEFGRCLHRIISFAGKAKTDCPINC
The following text describes a protein:
Function:
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MASRPWCGVFTAKGVPVYQTLHLAVLMCLQVILQNLSLAYSSVIFHQLVRLLLTPLTALLNYLLYRSRIPTASIIPLIMLCAGVGTMSYYDTLPRTDGKITASSKGAVFAFTGVVASALYTAFVGRYHRKFEISSVQLLLNQAPLSAAMLLCVVPFAETLPATAGLSTSLYVSIMASGILACLVNLSQFIIIDSVGPVSSTVIGHLKTCIIVGLGWALSDRPISRGCLVGILMALTGMTFAWQPLKSCDSCANCSNAAVDMPDETVATYEVVTLLECLS