lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription. Acts as a negative regulator of the calcineurin/NFAT signaling pathway.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Endomembrane system. Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Cell membrane. Membrane; Lipid-anchor.
Sequence:
MGSRASTLLRDEEIEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFFSEGEDQVNFRGFMRTLAHFRPIEDNEKSKDQNGPEPLNSRSNKLHFAFRLYDLDKDDKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDCAISFAEFVKVLEKVDVEQKMSIRFLH
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTLNNLTLYTTTAVLILDTDGNRVIAKYYQPPHAANFALTATPAQQNAVASTTPQLAAKNPLSTLKDQRAFEKAIFDKTKRATGDIVLYDSHLVLFKASLDVIFYVVGPAAENELMLSGLLSAFYDATSMLVRHQVEKRAILENLDLVTLALDETVDDGIILETDSTTIASRVSRPRPDVNEIQINEQTIMSAYSSLKERVAQRILQGGL
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Sequence:
MRLQRHAAAGLGATKHRDTLTARLPCQSTRGRAALQVACVATPHSADSQKGAPKATATPSGQYVSSPYGAGRVLTPSPPGSIDDDDVLELKNLRNYLVPRDSPFIVDNNQGGGFVGDRDRIRLHTVEFESTESAGSFCADGVLTNGDEDSCILLPEWAIRCGPRKTIYFDPQQVSAAVVTCGGLCPGLNDVVQNIVYTLTDYGVPEDNILGIRYGLRGFYERDAKPITLTRKYVDGIHLKGGTMLGTSRGGANVKEIVRRIDLWGLNMVFVVGGNGGNAAANAISEECEAQGVCCSVVGVPKSIDNDILIIDKCFGFETAVQEAQRALLAAKVEAGSARNGLGVVKLMGRQSGFIAMQAAMASGVADVCLIPEIPFRMDKLCEHVESIFEKQGHCVVCVAEGAGQDLLTAGGTGGTDASGNPILADIGIFMRNEFKKHFKGEADIKYIDPSYMIRSVPTTSNDRIYCKVLGQGAVHGAFAGFTDVTVGLVNTHYVYLPIPTIIQAARKVNPKGRRWNRLITAIRQPDMA
The following text describes a protein:
Function:
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Sequence:
MGCERGLLRALSWTLLGAAALLWPLRRRTGGRRWAPYGRHGGRGRSVPARAAWALQELPSVLVPLGLALRNRHRRLPHWPNRLLLAMFLLHYLHRSLVFPFLIRGGKPTPVSTFIMAFLFCSFNGYLQGQNLSKYAVYPTSWLRNPRFIIGFLLWLIGMLINIHSDHILRNLRKPGETGYKIPRGGLFEYVSGANFFGEIVEWYGYALASWSVEGAAFATFSASFLINRAQLHHRWYLEKFEDYPKLRKILIPFLF
The following text describes a protein:
Function:
Catalyzes the transamination of glyoxylate into glycine using L-aspartate as the preferred amino group donor. Is essential for the growth of P.denitrificans in the presence of glycolate and glyoxylate since it functions in glyoxylate assimilation via the beta-hydroxyaspartate cycle (BHAC). Can catalyze the reverse reaction in vitro, and also use L-serine and L-glutamate as amino group donor, but with much less efficiency than L-aspartate.
Miscellaneous:
MISCELLANEOUS: The beta-hydroxyaspartate cycle (BHAC) consists of BhcA, BhcB, BhcC, and BhcD enzyme activities. Overall, it converts two molecules of glyoxylate (C2) into oxaloacetate (C4) without the loss of carbon as CO2, under consumption of just one reducing equivalent and regeneration of the catalytic amino donor, which makes it one of the most efficient glyoxylate assimilation pathways. This cycle is of ecological importance in the assimilation of phytoplankton-derived dissolved organic carbon in marine environments by marine Proteobacteria, and suggests a trophic interaction between autotrophic phytoplankton and heterotrophic bacterioplankton. Oxaloacetate formed in the BHAC can directly enter the tricarboxylic acid cycle or serve as substrate for anabolic reactions.
Sequence:
MTSQNPIFIPGPTNIPEEMRKAVDMPTIDHRSPVFGRMLHPALEGVKKVLKTTQAQVFLFPSTGTGGWETAITNTLSPGDKVLAARNGMFSHRWIDMCQRHGLDVTFVETPWGEGVPADRFEEILTADKGHEIRVVLATHNETATGVKSDIAAVRRALDAAKHPALLFVDGVSSIGSMDFRMDEWGVDIAVTGSQKGFMLPPGLAIVGFSPKAMEAVETARLPRTFFDIRDMATGYARNGYPYTPPVGLINGLNASCERILAEGLENVFARHHRIASGVRAAVDAWGLKLCAVRPELYSDSVSAIRVPEGFDANLIVSHALETYDMAFGTGLGQVAGKVFRIGHLGSLTDAMALSGIATAEMVMADLGLPIQLGSGVAAAQEHYRQTTAAAQKKAA
The following text describes a protein:
Function:
DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MTVTNFSELDLDERLIDALRDKGYERPTAIQASAIPPAMDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPRKKSGPPRILILTPTRELAMQVADQARELAKYTQLDIATITGGVAYMNHAEVFSENQDVVVATTGRLLQYIKEENFDCRAVETLILDEADRMLDMGFAQDIETISAETRWRKQTLLFSATLEGEAIREFAERILNEPVELEADPSRRERKKIQQWYYRADDIKHKTALLCHLLKQPDVSKSIIFVRTRERVHELVSWLREAGINAWFLEGEMVQAKRTEAVIRLGDGRVNVLVATDIASRGLDIDDISHVFNFDMPRTADVYLHRIGRTGRAGRKGVAISLVEAHDHILLGKIGRYLNEPLKPRVIDELRPTSKAPSEKATGKPSKKVLAKRKEQKESSKEKVKVKVRHRDAKNVGKRRTPKAKPDTKSAG
The following text describes a protein:
Function:
Has a dual specificity toward Ser/Thr and Tyr-containing proteins. Dephosphorylates MPK4 in vitro.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSSRDRGSPSSSSSSSSLPGIEKYNEKVKNQIQALVRVIKVARTYRDDNVPSLIEQGLYLGSVAAASNKNVLKSYNVTHILTVASSLRPAHPDDFVYKVVRVVDKEDTNLEMYFDECVDFIDEAKRQGGSVLVHCFVGKSRSVTIVVAYLMKKHGMTLAQALQHVKSKRPVASPNAGFIRQLQDLEKSMQVSDQFFSF
The following text describes a protein:
Function:
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase.
Miscellaneous:
MISCELLANEOUS: Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin).
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus speckle. Note=Localizes to the inner centromere throughout prophase until metaphase and disappears at anaphase. Centromeric localization requires the presence of BUB1 and the interaction with PPP2R1A. Colocalizes with NEK2 at the kinetochore. Colocalizes with and SS18L1 at the kinetochore. Phosphorylation by AUKRB and the presence of BUB1 are required for localization to the kinetochore. Isoform 1 primarily localizes to kinetochores during G2 phase and mitotic prophase, metaphase, and anaphase and does not appear to be associated with kinetochores during late mitosis. Isoform 3 is found at the centrosome in interphase and at spindle poles in mitosis and its spindle pole localization is PLK1 dependent. Isoform 3 does not localize to kinetochores during any stages of the cell cycle.
Domain:
The KEN box and D-box 3 are required for its ubiquitination and degradation.
Sequence:
MAKERCLKKSFQDSLEDIKKRMKEKRNKNLAEIGKRRSFIAAPCQIITNTSTLLKNYQDNNKMLVLALENEKSKVKEAQDIILQLRKECYYLTCQLYALKGKLTSQQTVEPAQNQEICSSGMDPNSDDSSRNLFVKDLPQIPLEETELPGQGESFQIEDQIPTIPQDTLGVDFDSGEAKSTDNVLPRTVSVRSSLKKHCNSICQFDSLDDFETSHLAGKSFEFERVGFLDPLVNMHIPENVQHNACQWSKDQVNLSPKLIQPGTFTKTKEDILESKSEQTKSKQRDTQERKREEKRKANRRKSKRMSKYKENKSENKKTVPQKKMHKSVSSNDAYNFNLEEGVHLTPFRQKVSNDSNREENNESEVSLCESSGSGDDSDDLYLPTCKYIQNPTSNSDRPVTRPLAKRALKYTDEKETEGSKPTKTPTTTPPETQQSPHLSLKDITNVSLYPVVKIRRLSLSPKKNKASPAVALPKRRCTASVNYKEPTLASKLRRGDPFTDLCFLNSPIFKQKKDLRRSKKRALEVSPAKEAIFILYYVREFVSRFPDCRKCKLETHICLR
The following text describes a protein:
Function:
Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Predominantly located in the nucleus with granular heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells. Colocalized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament protein vimentin.
Sequence:
MGRRSTSSTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRAAVLKMKDPKQIIRDMEKLDEMEFNPVQQPQLNEKVLKDKRKKLRETFERILRLYEKENPDIYKELRKLEVEYEQKRAQLSQYFDAVKNAQHVEVESIPLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPTRAVSILPLLGHGVPRLPPGRKPPGPPPGPPPPQVVQMYGRKVGFALDLPPRRRDEDMLYSPELAQRGHDDDVSSTSEDDGYPEDMDQDKHDDSTDDSDTDKSDGESDGDEFVHRDNGERDNNEEKKSGLSVRFADMPGKSRKKKKNMKELTPLQAMMLRMAGQEIPEEGREVEEFSEDDDEDDSDDSEAEKQSQKQHKEESHSDGTSTASSQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPFLRPPGMPGLRGPLPRLLPPGPPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPPNLIQRPKADDTSAATIEKKATATISAKPQITNPKAEITRFVPTALRVRRENKGATAAPQRKSEDDSAVPLAKAAPKSGPSVPVSVQTKDDVYEAFMKEMEGLL
The following text describes a protein:
Function:
Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity).
Subcellular Localization:
Nucleus. Note=Closely associated with pericentric heterochromatin.
Sequence:
MPAERPAGSGGSEAPAMVEQLDTAVITPAMLEEEEQLEAAGLERERKMLEKARMSWDRESTEIRYRRLQHLLEKSNIYSKFLLTKMEQQQLEEQKKKEKLERKKESLKVKKGKNSIDASEEKPVMRKKRGREDESYNISEVMSKEEILSVAKKNKKENEDENSSSTNLCVEDLQKNKDSNSIIKDRLSETVRQNTKFFFDPVRKCNGQPVPFQQPKHFTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATIALMIQRGVPGPFLVCGPLSTLPNWMAEFKRFTPDIPTMLYHGTQEERQKLVRNIYKRKGTLQIHPVVITSFEIAMRDRNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQILTPFLLRRLKSDVALEVPPKREVVVYAPLSKKQEIFYTAIVNRTIANMFGSSEKETIELSPTGRPKRRTRKSINYSKIDDFPNELEKLISQIQPEVDRERAVVEVNIPVESEVNLKLQNIMMLLRKCCNHPYLIEYPIDPVTQEFKIDEELVTNSGKFLILDRMLPELKKRGHKVLLFSQMTSMLDILMDYCHLRDFNFSRLDGSMSYSEREKNMHSFNTDPEVFIFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQSGLNLSKNFLDPKELMELLKSRDYEREIKGSREKVISDKDLELLLDRSDLIDQMNASGPIKEKMGIFKILENSEDSSPECLF
The following text describes a protein:
Function:
Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The complex binds polyphosphoinositides.
Subcellular Localization:
Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MALSGMRGLSVFISDIRNCHNKEQERLRVDKELGNIRTRFKNEKGLSHYEKKKYVWKMLYIHMLGYDVDFGHMETVSLISAPKYPEKQVGYIVTSCLLNENNDFLRMVINTVRNDIIGRNETYQCLALTMVGNIGGKEFSESLAPDVQKLLISSSCRPVVRKKAALCLLRLYRKNPDVVNIDGWSDRMAQLLDERDLGVLTSVMSLFVSLVSNNAEAYWNCLPKCVRILERMARNQDIPQEYTYYGIPSPWLQVKAMRALQYFPTIEDPSARRALFEVLQRILMGTDVVKNVNKNNASHAVLFEALALVMHLDAEKEMMSQCVALLGKFIAVREPNIRYLGLENMSRMLLVTDVQDIIKRHQAQIITSLKDPDISIRRRALDLLYGMCDVTNAKEIVEELLQYLNTAEFAMREELALKAAILAEKFAPNLSWYVDVILQLIDKAGDFVSDDIWYRVVQFVTNNEDLQAYAAAKAREYLDKPALHETMVKVSAYLLGEYGHLLAQRPSCSPKELFTIINDRLPTVSSSTVAIIISAYAKILMHTQPPDAGLQQQILAIFKKHESYIDVEIQQRAVEYFELSRKGPALADVLAEMPKFPERESALLKKAEDAEVDTAEQSAIKLRSQQQSSSAIVVAAQPPVNGPAPAANHLTLVKMPSQNIAEESNVIHEETAVEAPKENGAPVEVQRNVEIITEPAPVSKVEPPASRPASQADLLADLLGPLAIEGPPAAVEQTPAQGLEANQSPVGDLALATLEDQSNSVQPIVNVEEKFNILCTKDSGVLYEDPNIQIGLKAEWRAHHGRLILFLGNKNTSPLLSLRALILPPSHFKVELSSVPDTIPPRAQVQIPVEVTNLRASRDVAVLDFSYKHGAALVNAKLRLPIVLHKFLQPITLSPEDFFAHWKTWNVQSLKVQEVVRGVKPLPIPEMASLLLSLHLAVTPGLDTNPNNMVACATFFSETTNAALCLVRVETDPQDRSQLRLTVASGDQNLTFELKEYIKEHLIDIPRARVAPPPAPQQPQMPPAAPATTYNDPGAMLAGLL
The following text describes a protein:
Function:
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity. Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses. Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor.
Sequence:
MEYSWLENKLQEINRKCIQINNKKSNNDSLNMIIGKLIDVMKDTSVLFKTLYERIIFNGSYYNNLKISKADEYDLDLILVLPVALETVLMLTPEAGYVDVKIDISKIKKLAYYRDILTPLEKLCENGIFSSLKIHSWFEGLVQKSLNIINASKYFPQYKLDMYKSGPAVTLTVHTPFSSYDMDLVPCLKLDKSLYPKGYKKQNCNHIYAVSKPNKDKEWRLSFIEQELSILRDNGHVKPAIRLLKFLRDQRDHKLIKSYFIVTVAMWDLETTNFNGKSLSFAFMTLLESLYKHICERKIPFYWNPNLNLLNKCHRDYLFNLENQLLNILKKLRSSNSNPNVLNEVFNFDIQES
The following text describes a protein:
Function:
Functions redundantly with tsp-12 to regulate cell surface levels of the BMP type II receptor daf-4 (but not BMP type I receptor sma-6), probably by regulating endosomal sorting and recycling of receptors, preventing their targeting to degradative lysosomes. Together with tsp-12, regulates cell fate specification in the postembryonic mesodermal M lineage, body size, male development and vulva development, probably by positively modulating BMP-like Sma/Mab signaling. Together with tsp-12 involved in maintaining the structural and functional integrity of the endosomal network. Together with tsp-12, probably acts by modulating the activation of glp-1, Notch-like receptor, to regulate germline maturation; [Isoform a]: Functions redundantly with tsp-12 to regulate cell fate specification in the postembryonic mesodermal M lineage, body size, embryonic and vulva development; [Isoform b]: Functions redundantly with tsp-12 to regulate cell fate specification in the postembryonic mesodermal M lineage. Likely plays a complementary role in mesodermal development with tsp-14 isoform a, but may be more critical.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note=Often in close juxtaposition to the retromer but not part of it, suggesting separate microdomains of the same endosome; [Isoform a]: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Primarily localised to intracellular vesicles; [Isoform b]: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Primarily localised to the cell surface.
Sequence:
MPHRAPRRFMKTAPGACDWEQCLLMGSGEPTRARAVVSSSHKQRKPRQEISACLKWLVFLLNSIVFLVGVGILALGVYLFIKDFREVKLVDIILNPAILISIFGFSICVVSFFGFMGALRDNIFLLKCFAACVFLSYILVVAVTLVFFTLFYTDTTEGLSANWLLLYAVKNYHTNRNLAEIMDALQENLECCGVSSIAQGYRDWNMSYQFNCTNSNPQPEKCGVPFSCCRKSVISEAAGSSNPLLPAMRSLECWQNALTKRPGDLEHDIYTRGCLQPLRTLFESHAVHVGAFVALLIVPVCISVCLTNILAKQVDHQRYLLEREARRNDRRRKRDHNRRDQLNSLDLLEEGKFNNASANATRPRPPDIPPPLPPIEHVPRKKSRNASSSPTRKPKSAGVENAAARRKRTATTTRTPPAAAGPAPTPQATTTNRTHQWVLQQTDLVPQKSKS
The following text describes a protein:
Function:
Required for cytoplasm to vacuole transport (Cvt) vesicles formation and autophagy (By similarity). Has a role in sporulation.
Subcellular Localization:
Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MPSIILYCSWNQDRGFLSIGSENGYQVYRSNPFTLCFSKKANGASICEMLYESSLLAFVNISPESTRLLKLVDIKRDIVLCRIFYPSPVLSVRFTWNRLVVLIKGSIYVYNLKNMELINTLNTSKGNVIAFAVHENYVAYNSPTNPGDIYLASLDTAIPVTLIHCHSSAVQVVDFHPRGHLIATASAKGTVIRVITTSDGELVTELRRGYIPASIVSISFHPVEPFLACASENGTIHVFKISKQPSDPNSSPTSSVTVSSSWSKYLTSNVAKVWDTRKEFATAKIPEASFYGKIIFSSSGPHIQVASYSGHYYRFAVNLKNGGNCALLERYIFDD
The following text describes a protein:
Function:
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity). This toxin acts on sphingomyelin (SM) wih high activity. It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity). It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity). Shows high hemolytic activity. Causes dermonecrosis, induces inflammatory response, platelet aggregation and increases vessel permeability. Shows no lethality when injected at higher dose into mice. May cause complement-dependent hemolysis as well as in a complement-independent manner (By similarity). The hemolysis provoked in a complement-independent manner may be composed of several steps (By similarity). The toxin may bind to erythrocyte membranes, may hydrolyze membrane phospholipids (SM and LPC) thus generating metabolism products that may cause hemolysis, probably by provoking an increase of calcium inside cells (By similarity). The calcium influx may be due to the opening of L-type calcium channels, since L-type calcium channel blockers inhibit calcium influx (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MLLHIALILGCWSVFSEGAETDVAERADGRRPIWNMGHMVNGIWQIDQFVDLGVNSIEFDINFDKNGKPVYTYHGVPCDCFRSCLNWEYFGEFLTALRHRTTPGDKLYKEKLILFVFDMKTNSLYDNQAYQAGVNMATDIFKYYWNNGQNGGRAYFILSIPNLNHYDLIKGFRETITKKGHPELMEKVGYDFSANDNIPDVEKAYGKVGVTDHVWQSDGITNCIARGLSRVKEAVKERDSGGVINKVYIWTIDKFSSTRDALDAGVDGIMTNYPYVLNDVLKEGAYKNKFRMATYEDNPWVTFKA
The following text describes a protein:
Function:
Sorting receptor involved in the transport of vacuolar enzymes from the Golgi complex to the vacuole. Involved in the delivery and maturation of PEP4 (vacuolar proteinase A) and PRB1 (vacuolar proteinase B).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein.
Sequence:
MLKRSSLIYLSCVLIITIPILLHVYNGPGLSHEANEHRASHKQKRTLANPDKPKSENDEDLFCAVTNPVTGSYIDLSQLSSTPNKLREGQKQISGNNKHESSKTKWSVRGWGYDTNFTLGICSSPVGEAESQQLSNLTGAFYVDQLNENNLVSIGDFSTRPALVGGSTAKKLTLKYENGSMCPNGKDKKATLLNFVCDKEIQSKAQISYIGNLHNCSYFFEVRSIHACPTSNKKNEVNVLGIFIGIFAIFFLVEFAGRRWIYAKLNRHLKNDDELHDISPSLNEQPHWDLIEDGSRWSKFFNGIIKTTRRFTKSLMRSLVRGRNSRQGGIRLRSSPSASSSSLANREFFRDMEAQNEIIDSLDINSHTTESDHPTLADNSV
The following text describes a protein:
Function:
Probable methyltransferase required to silence rDNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEKKPSSKRKRAKRLKSQNKKLRHEKDNSAAVEEVDERQEEEKEEPSTSAFAKRTKSQGFSKSSTFLDKMKARLSGGHFRMINEKLYTCTGKEALDYFKEDPALFNVYHAGYQEQMSHWPEQPVNIIIKWLKNGSPSLVVADFGCGDARLAKNVENKVFSLDLVSNDPSVIACDMSKTPLDTSVIDVAVFCLSLMGTNFASYLKEAHRVLKPGGWLLIAEVKSRFDPNTGGADPKKFSKAVCELGFTSELKDFSNKMFIILYFKKKDKQNPNRKEIQWPELKPCLYKRR
The following text describes a protein:
Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Sequence:
MPELPEVETVARSLAPQLQGRTITGLAKLDWPKMLTPSPDEFAALIAGRRIEAIGRRAKWLLLSLDGEWTLAIHLRMSGQLLVAEPETSEARHVHFALDLDNGRRLIFNDQRKFGRVHLLDRQGLAALDAVHGPEPLAADFTPSALAERLQNRRAPIKALLLDQHLIAGIGNIYANEALWLARIHPLTPGAMLTPEQINELHHAIRHVLQEAITNQGSSLRNYRDGYGRQGTQQEHFNVYDRAGEPCPRCQSTIERIVVAQRSTYFCPTCQITMQQPE
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MAVTPLLRICQFSAFSIAVSANLLLLYLIKMRAGTSFGSYRVMMISFSMYAIVYAFIEILTMPVLHIHKSGVLFYVDSVLKFNPIIGELMSSLYCGSFALCISMLATHFIFRYVAVCKPHKLYHFDGNKIYQLFIPPTILFVIWTLSIYFNFGPNQVKKDFFRRVAWELYEEDIDKIAFMGPLYFTRMENGKRLFRFPDLFGAFISCTIMAICLTTCVVCAFKTYRKLNDLTIQMSERTRSLNKQLFWTLGLQTLLPCVTQYIPVGTMFFVPLFEFDLGRIGNLVGAACSLYPAMDPIIAIFMIDRFRNFVLRKEFHTVSKTSKVSAVNEERRSTIPDHII
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MLNSLDLEGRPQDTRVVVAMSGGVDSSTTAALLKAEGYDVVGITLQLYDHGAATHRKGACCAGQDIHDARDVAAKLGIPHYVLDYEDRFRESVIDNFADSYALGETPVPCIECNRSIKFRDLLKTARELGAQALATGHYVASRRLDDGSRVLVCAADADRDQSYFLFATTQEQLDYLRFPLGDMTKPETRELARRFGLAVADKHDSQDICFVPTGRYTDIITRLRPNAMDPGDIVDLDGRVLGRHNGIANFTVGQRRGLGIAAHAPLFVVRLEAANRRVVVGPREALKMHRISLRDVNWLGGGDIDSAIGNGLEMFVRVRSTRSPQPAWLRGAGGHYEIELVAGEEGVSPGQACVFYDAPSGQARVLGGGFIQSAAAKVASNPARPLVEAVRG
The following text describes a protein:
Function:
Primarily acts as an independent SigF regulator that is sensitive to the osmosensory signal, mediating the cross talk of PknD with the SigF regulon. Possesses both phosphatase and kinase activities. The kinase domain functions as a classic anti-sigma factor-like kinase to phosphorylate the anti-anti-sigma factor domain at the canonical regulatory site, and the phosphatase domain antagonizes this activity.
Sequence:
MGRQEQILGAVNLDRELRVTHRNLEAPVFAGLDAAVGSPFVDLLPPGDVPTVTRRLRQVLDTGEAHVARVQRLRRGDGSELVVSMSILPAAAPREGLTVSVIAMARRLHLYAAETAIGTSLDIGETAQSLAESLLAWGDVAAVDLDFAVWTGEGVTERAQGRIRLRRAALVPDRAWPEGYVTLGEDLPSDASRLLSQAIRRADAPQSIVIPDREAIERVLGSPRLVRALVPGDRSAGVACVPLVLEGDPPVVLGVAEVWRRADRPFADSELFDLQELVARTSHHVDLARQHQREHTQVLALQRRLLPRSAGGTVQTASVYQPATPDSAGVGGDWVNSFPLPDGRTALVVGDVVGHGLGAAATMGQLSMEARALLSAGLAPDEVLEHLDETVTLLDDAESGLAAGYSALGSTCCIAVYDPVSHRVTLSSAGHLPPILVSPDGRAGPLPVRPHPGLGTEFALREPYGVHTFVAPPGSLLALYTDGLVEDPAVPIDEGIARLADAVSGVHPWDSLQQAARRVVSDVMPAHQRDDVTLLIARTIGYRKGDTATWRLPARDDAAARARALVSALLRQWRTRDSTRDSVLLLVSELVTNAVRFAGGPITVRLIRAGPGLLCEVGDTGNGRPRLGRGGLLDDGGRGLHVVHRLTTRWGVRWTDTGKVVWAEVVR