lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a part of the autophagy-specific VPS34 PI3-kinase complex I that plays a role in autophagosome assembly. This complex is essential to recruit the atg8-phosphatidylinositol conjugate and the atg12-atg5 conjugate to the pre-autophagosomal structure.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Domain:
Coiled-Coils at the N-terminal half are essential for autophagy.
Sequence:
MLHVNKCQLCETRRPSICESCLKKQLYDFYHKRDEFSRDIESELEKVAKLKSESFSLKGKITQKEELTYRLQNLAASLNEKKSLSCDLHSRKQLIEDDLSNRKKSINIASQKLAGLSHSTSDYFSKEYLTAYRRSELLQNKLHEYQKKLITRVLDMYQLHWQRDLVLNTQGCTQKSAQMGSEFNPDSIDSSLAYRLSKLSMGNSKSDLSHSDNETGHFYSNFFSQVMELNASVTISGIPVCIRSKEKMFLNPDCALTLSFICIFLAQYTSIPLPCPLQLPSPDQKPMTSFSSEQMLYIMYNIVWISWNCGIFSFPRGITQSQLFELMQYTGFWLVQLRTKPLTSQKPDWHYKMGMDFDLFHRLYLARLPIPINYSSLRSRSSSKPYQLIS
The following text describes a protein:
Function:
Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Plays a role in apoptosis negative control involved in brain development.
Subcellular Localization:
Nucleus speckle.
Sequence:
MEVHRALERLHMTIFSQSVSPCGKFLAVGNNYGQIAIFSLSAALSSEAKEESKKPVVTFTAHDAPVYSLVSTDRHLLSAGDGEVKAWLWGEIVKKGCKEVWSRHPPYRNSLEVPEINTLLLNPKENSLLLAGGDCLLHTMDLETGTFTRSLRGHSDYIHCLALRERSPEVLSGGEDGAVRLWDLRTGEEVQTIEVYKHEECARPQNGKWIGCLATDSDWMVCGGGPALTLWHLRSATPTTVFPLRAPQKHVTFYQDLILSAGQGPCVNQWQLSGELKAQVPGSSPSLLSLSLNQQPAAPECKVLTSAGNSCRVDVFTNLGYRAFSLSFS
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins.
Sequence:
IDSLGILSPPDRDSTTPPRAFSEAAAPPARRREIRFAPLHVAWLQMNQPEVNGLLCVGLHQTDGGDELYATECLKMNQGSSHETNKLDAVMSASTMHSDHNNANACVDDYQHTKMMAGIQPMEEVGFGCTQPFELQSQGIVPDSEEESLPSSPETSSTSNYDMPDLAEQNLEHIYNVLGEMVDKEGPVVLSPEYVMCGTTSHVEPRLTFSADGFKIEYWDSCENDEMAAQYWKISDITCIDCKWAQSVGSVLITLHVGSGTETGNSSHDRIQFCLIDSQWPRKQQNIWHLASRYQEIWNNIPSGDFASENWNIEPSLFFPKQYFSDTEEFEDVIYPKGDHDAVSISKRDVELLLPETFVNDTIIDFYVKHLSTRIEPAEKHRYHFFNSFFFRKLADLDKDQGRAPEGRAAFLRVRKWTRKINIFTKEFLFIPVNFNLHWSLIVICYPGEVETFKDGDTNISAKIPCILHMDSLKGSHSGLKDIIQSYLWEEWKERHPESASDCSDKFLNLRFISLELPQQDNSFDCGLFLLHYVELFLMDTPRSFNPLKIDSFANYLSDDWFPPAEASLKRSLIRKLIHKLLKEPSQDFPKLVCCSEQLDKTHGSENAELEQMSENAEREQAKELPAQMCTDGEPDSVGTILETQQPSISTCFNYSDENGPPVSVHNLHKLEVSSANKDAIVCLSNHDEKNESPPADSYNHLDLRSCDSEEAETAKGSAGVVKDPNSHKEPLLDSLDNNQDISIQAGAEMHDSMDSKLCSISNNADLMASEERSLDKNTNENEEHNRTSEDIVESVMMLGGSKSDTELDAEPERTAGEAEVRNCDHSKDIDYIALGDINKDAAKQSLNRNIVEAEDIKCEGTLVDHTVVEDATPYNVNETSASADKINDNEHNVSSELKEGNNGNGITTSISCEMEDRSIDNLMVGDSRNGTDETRADGQEAHDNSATAETVPCEDNATTSITDAEMPHEDSTCSVKGEAISDNTASDAKRPLPDSTYIEDIPDDKCLQKDDGGGDEAKTERHYKRRKFLVSEATS
The following text describes a protein:
Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPTKGKYFLNDDEEWKSKDSRYEQFHHMSQHYPFLLIFLSIAIISSLILIVLSFFHSTRPGHLAFLVTAFLTLILFAIIYALVYVECLFQKWLKFFAVVIWICFLTLGFVLIFDFKNEKNFVWEQVPFFLFIIFTVYTMLPFEMKDAIVVNVLSTLSYLLVVGVRAEVFKARPPLPLVLQLLANTTIFLCGNLMGAFHKSQMQDASKDLYIYTHKYIQLRRKLKIKKRQQENLLLSVLPAHISMGMKLTIIERLKENNDRRNMPDNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCEAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMESAGVPGRVHITEATLNHLDRAYEVEEGNGQQRDPYLKEMNIQTYLVIDPRSQQQQPPSNHLSKPRANDALKMRASVRMTRYLESWGAARPFASLNHRESLSTEILIPKVRRPKAIPLRRHRDAERNASPKGKTEEDTYDEELMLTIEGLSLARPCCCGNSDDFYTIGTFFVEKNFEKEYRTMPVPRVRNYFACAGFVFFCLLLIHTLVMPKTAEMGVSFGIVACVMLLALGACFADDFLRFCPEQSCLHAFRAISEKVETEPLLRLSLAILTIGSLLTVAIVNLLFLPPSPKDSGNTTEMSHRNSTNIECLVLPYYVYSCILAFVACSMFLRMSLELKVVMLTASAIAYLTIFNARSIPDCNSCLGGNRDALSNDASPSPPSCPTPLFMKDLKIMINFYLILFYVTLILLSKQIDYYYRLDYLWKNKFKKEQEEFETMKNVNHLLLENVLPTHVAEHFIGDKLTEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSLTPGQENNQDQERQHAHIGIMVEYSIALMNKLDGINRHSFNTFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCNILQKLGYSCECRGLINVKGKGELRTYFVCTDTTKFQGMGLN
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MLNTGLRKGLALSPITHLLKRCSSVTDNVHRVNYCYNYHTVPNLSQRNLLPLFSPEALDIAWDQHQRQVVKELNDRVKGTELEDSSVFNIIFQTAALPEHAATFQFASQAYNNHFFFQSLIGKRAADAKKNSKYEANAAINKAVNENFGSKENLLSKIHELASNSFGACWLWIVIDDYNRLNLLRTFQAGSPYLWTRWQSNDPHLISSVPDYSARPRKYAHVPILNLCLWNHAYYKDYGLLNRSRYIDTWFDCIDWSVIEERLTNSLV
The following text describes a protein:
Function:
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
Miscellaneous:
MISCELLANEOUS: In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
Sequence:
MERQTDEFAQAAARAAIRFLEHYAGSGDEVLANCTERLFQALQNGHSFIRLSGGEADALSALAPVVGTSAAPLILEGRRLFLGRMWQLEYDLAAEIKRLAAAGTSAPDAAGARQNLAKWFQGTGSEGQRDAAALALLQSFMVITGGPGTGKTTTVAKLLALICGEDENLPNIALAAPTGKAAAHMARALHRAINGFDAPEAVRRHLLKLEGQTVHRLLKLRPPKMQAAFNPVYPLPFDVLVIDEASMLDTALMLQLLKAVKTGARVILLGDENQLPSVGIGAVLSVLSQKTVLDGETHQRLAGFLPEHGFSVSANPPVLAQNTAHLSFSHRFGDNSGIGCLARAAVSGDEGAWALFDRFPDELEHSECSPNARVERLYRAHKAYWQAVKDGNIEAAYAGISDIVVLAAWRQDAEDFNEAYCRHVRRKMNIPEHLAYFAGEPIMIRQNDYALELFNGDIGLIMEDVGRQGSLAAYFADADGFKKVAVSCLPEFEPAFAMTVHKSQGSEYREVWLLPPSAAPSDEGDDALSGLSKELLYTAITRAREKFVFFGGEEAFRQAAATVKTRQTALGSMLERVFSQE
The following text describes a protein:
Function:
Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient. May also transport beta-alanine. Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake.
Subcellular Localization:
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Presynapse.
Sequence:
MATLIRSKLSNVATSVSHKSSAKVSGMFARMGFQAATDEEAVGFVHCDDLDYEHRQGLQMDILKSEGSGEEGGGEAPLEGDTHYQRDGTGPLPPSGSKEQGLSPEQDRPRITAWEAGWNVTNAIQGMFVLGLPYAILHGGYLGLFLIIFAAVVCCYTGKILIACLYEENEDGETVRVRDSYVDIANACCAPRFPALGGRIVNVAQIIELVMTCILYVVVSGNLMYNSFPNLPVSQKSWSIIATAVLLPCAFLKNLKAVSKFSLLCTLAHFVINILVIAYCLSRARDWAWDKVKFYIDVKKFPISIGIIVFSYTSQIFLPSLEGNMQNPKEFHCMMNWTHIAACILKGLFALVAYLTWADDTKEVITDNLPSTIRAVVNIFLVSKALLSYPLPFFAAVEVLERSLFQDGTRAFFPNCYAGDGRLKSWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLKLLWRKLLWHHVFFDVAIFVIGGICSVSGFIHSLEGLIEAFRYNTED
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MASTPSSSTFPIPSSFQELESPPYNLLPYPHSFSDDDEAARAESFEVLIRIVEGGNRTLVNSSGLALFEEEEEEEEGECDAWNDGVRIQALYTLVRKSDSLAPATRARLVKALCDAVHHLSSALANPGNTAMSSSSSPENNSTNNFVVSQSFRDAYACHIYMLFTLMFFTESQEKLGKSLGVTSSTSSNSRSKKTTKKKNNSTNNSSTPSDSEALQTSRTLCATAMLTASQSMSTFASRLWKRSVPDEAVIHLPCRIAYQMLESAMGVIARKASCGDEALKMIATTVDTYASCLLNTVVAALVDLLHTYDHMAVLVAELCTLVKETPSNILATELLREIGRLDTEGCHTETGGKASGIKNVAPFISELAAVRPKVVLANISLLLPHLDAEPYVLRSAIVNSIGCILVRDDVFAEDNNNNNKKVAASAVQAEKDKDGDSSSSDDNGEQEFKGEKKAVVKANTRASLFHILCDRTCDITSFTRAAAIKVLNDLTEKSSLPLDRIMPVTAIAIDRLQDKTVMVRRYSMQLLTSLLENNPFMGMLNPEPYRDKIIELEAYLKSNVPEEILKARDAALEETKNDEDGTMRELQEIESAALAAAIADAEAKRESEELSEAESQFLAKVRALKFASSALSFIEQFENANASFQTMLLSSNSSDVTEALRFFVRAKNFGLPCAVTGTKRSLALMWSNEVSIQDEVLRAFIEVFVAEPGSEGKELLPENQIAQNFLDLVGEATVSELASIEEALGRLVKKEIIPPEVFSILWQMASQAEGKLRASAMLVISMAASADPKIVDSAYRLQNLYDAGLGDYTEEHRDWKTARSAACALQRVARAKVDPSSAKYIILDLITERLVAVARGDWCQDESEADTNEWFCAAEQAINAIFTISPSPEKVAIEILLGHQAGIFGSPENPCNSANSLRLSRFFFVLGHIALKLLIYTEVLSSSVRRANAAKTVKKQESASGPKSSEDDAESKEDDEEEDAIEAELGIAAQAEAETERKVAEISENEIVGRGVISLFTPMLLRVVANEEGNYSSPTLMLSATLALCKCMCVSKSFCEKHLPLLFSVLAKAPNDDQDLRANIVVALGDLAFRFPNEVEPYTPKIYACLRDKSTRVRRHTLMVLTHLILNDMVKVKGQVCEIALCLQDQESGIRDMARLLFHELSKRTNSPIYNLLPDIVSQLSQLCLKQEIFREIMMFLLSFIKKERQNEMLLEKLIQRFPKCTAINQKADLAYCIAQLKINDKCVKCLNDTFKLYKDALFDEDVLKNFMSVVSKAKKNSKLETKDTIQELEDKLNENAAAGLENVKANKKAQRAKARAAKRVAHKKKVQEWEGESEGEEDKQSEAEMEDEADEENVSGNIQLPADGEGTKRRSGRSSRSKAVVA
The following text describes a protein:
Function:
Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSHQQPLSSSVQPTDIYGGDEVSALVLDPGYCNTRAGYAGEEMPKQVLPSFYGHINGRDVFGDEYIVPKPGFEVRNYMNRDSVVEDWDAATRMWEHVLVKRLQPERSTPPSKKGINISDDGDVPMEDDGNNNEDATDALEKPLAENPLLMTEAPWNSPKAREKAIEISMETWGVPAFWLSKTPVLAAFAAGKATALVIDVGGANTSVTAIHDGMVLKRSIQRSPVGGVWLSSQICKMWDGSEPKVDVVPRFMVESKKPVEAGAPAEANLRKFNFDIHPSFRAYEEERVLTEFKESVVEVWRGPQRFTTPGNEDAVRTQPGRVFEMPDGSNQMWREQRFKVSEGMWDETAAYNSTDEEGRVTKAQTIPALIKAALEGVDVDLRPNILGNVVVTGSTSLLNGFNDRLNHELAQMYPGVKIKIHAAGLTTERRFGAWIGGSILASLGTFHQMWISRKEYDENGAGIVEKRCK
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MLLYYLAAIFKGLHPRVDDDFVDKLNYHYTSAIIFAFAIIVSAKQYVGYPIQCWVPAQFTDAWEQYTENYCWVENTYYLPLTSAFPLEYGDRRARQISYYQWVPFVLALEALCFYIPCIMWRGLLHWHSGINVQSLTQMACDARMMDADARAATVQTIAGHMEDALEIQREVTDVSGMCVQKRWANYVTLLYVFIKMLYLGNVVLQVFMLNSFLGTDNLFYGFHILRDLLNGREWEVSGNFPRVTMCDFEVRVLGNVHHHTVQCVLMINMFNEKIFLFLWFWYFMVAFVSAVSMFHWIIISFLPGQHMKFIRKYLRATDLATDRQSVKKFVHKFLGYDGVFCMRMISAHAGDILATELIVALWHNFNDRVRKSPIEMFEGGVTQSPSKLDANFKTWLLGQTRGKPPFDGSNPTRGKKRRKSDGYFTFV
The following text describes a protein:
Function:
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
Sequence:
MSSSKMTNYHSGSAEALPPSSATNAVLVASEPVPKGSHEVRGVDFDRFQGRDITVAELVDNMVHMGFQGSAVAEATRIINDMRAYRHPETGEKTTIFLGYTSNLISSGLRDTIRYLVRHRHVSAIVTTAGGVEEDLIKCLAPTYMGSFSTPGAGLRAKGLNRIGNLIVPNSNYCAFEDWLIPILDKMLEEQEEAKKKAFRTGDEEDELHWTPSRVIERLGREIDNEDSVLYWAARNNIPIFCPALTDGSLGDMLYFHTYRSSPQRLRVDIVDDVRRINTMAVRAARAGMIILGGGVIKHHIANACLMRNGAEHAVYINTAQEFDGSDAGARPDEAVSWGKIKADANAVKVYAEATVVFPMIVAASFARSSPTPSAEDSDNHN
The following text describes a protein:
Function:
Multifunctional protein which functions as a transmembrane receptor in the planar cell polarity (PCP) and is involved in the assembly of the proton-transporting vacuolar (V)-ATPase protein pump. As transmembrane receptor mediates fz/PCP signaling through interaction with fz and stabilizes asymmetric PCP domains through its interaction with stan. Also mediates Wnt/beta-cat signaling through interaction with fz/fz2. Probably by controlling the assembly of the V-ATPase pump and thus the acidification of the endo-lysosomal system, plays a role in many neuronal processes including synapse morphology and synaptic transmission; [ATPase H(+)-transporting accessory protein 2 N-terminal fragment]: Stabilizes asymmetric Planar Cell Polarity (PCP) domains through its interaction with stan.
Subcellular Localization:
[ATPase H(+)-transporting accessory protein 2]: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Vesicle. Apical cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Co-localizes at the apical junctions with stan; [ATPase H(+)-transporting accessory protein 2 N-terminal fragment]: Secreted. Note=Localization to the planar cell polarity domains depends by stan.
Sequence:
MLRVFVIFSLFIAAINASGEFTVLNRPKAISFKGNDALESHYVGDVLYASMGNAVSGDTNWNGLTINDPFNLAKGVILVHVQGIGHVTTAGNVKTYELTGSGTDASLNALAAELEAANEPVCDINFEQFDDGVQAWKSCFGDFEAPAAKPTKHLNPSLHTADKQFLQEVGFINSAADHLAEMAKPSNVLMLRVSVDGVAKAHGEKSVAVEEANKLLSAAISRLLAASQKSSDSVLFVQTTEKDVAASRAKRDTIAASTTNPYNLAVYYGSDYPVIFNIILWFMVVFGLSLLAICYAIAAMDPGRDSIIYRMTSTRIKKDN
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MFNYQQTYLKSIRKMSAAGTKNEGRSRFSDEQIRFLECMFETHSRPELKMKQELAKTLGLQPRQVAIWFQNRRARSKSRQIEEEFNSLKHNYEMLASMSECLKEENRALVTQLQTLRELAKTQEGSVTLTRNFTNKNNNEDLGPVSVANDSKFISEDCRHEISVPFYGGTSYVGEDDIILDIEDYGFFQDGGGSRGFLG
The following text describes a protein:
Function:
Involved in several behavioral responses including chemotaxis towards lysine and adaptation to repeated osmotic stress. In addition, plays a role in resuming egg-laying and locomotion after starvation.
Sequence:
MVQLDRFEILFNNPEQAYFAGQEISGKVIIENKEPKKVNEILLELKGRARTYWTKHSGKSRKHCSHSEPYFLEQFNPGYTHKFTVVKDGKEKERILPAGIHQVPFSYTLPKSLPSSFEGEFGHIRYTCKAICERPWDFDIVSRKAFTVVGIEDINSDPKLNEPATCVESNHAVTFCCRSAGSVTGEIRISKCGYTPGEKIDVSFKVINLSSKTRTTALRFVQQTTYKAKTFAGHEHIKNVVRVISKIDKGEVPGGSTTEWQEESITIPSLPPKLGKCKILSVTYSVELEVEQTLTVPCPIVIGSIPQLSQLLIHSKQSVQSAGNGSLPKSSIKDSPPKWDSESCVQVTITDESGQLVEELGNEMEALLSARKRVRMPSSILSELYPTMPSPYYKESFFGASDISEEKEQAQFGEASFAPKYPFYTD
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MRPPQLETCDKFDIYVVRILEFVIIASPGPPLLPLTLQIANSRKHPSRFRSTLQAVNRQEEMNQETNHHHHHLLGIPPPNDHQPLTNQFEVFLNQFNRITQTVFTQIASSSSSSLSSSSSTINSNQTNPEITVLQEIIQLEIYLYKLLEINSQHDRNSKKIQNLYLTLNSLNSNQFKKKLDQIFSIKNKLDLICSDGQNEKNRFAELNQLALTPGHIMSYARLIAPYTSAPPAPSTADQDQPINPSSGLDLQDPSLRFLMPFPTEDVIRRGRMGQEMSAPVNGANDPLNGGTEIGALLGEIRTADGARPTQNQINPHLAAYPTMPSRRPPPPPLPDAEDDLFDLDLNPDL
The following text describes a protein:
Function:
Transglycosidase operating by a ping-pong reaction mechanism. Involved in the synthesis of raffinose, a major soluble carbohydrate in seeds, roots and tubers.
Sequence:
MAPPSVIKSDAAVNGIDHSGKPLFRLEGSDLLANGHVVLTDVPVNVTVTPSPHLADKDGEPVDASAGSFIGFNLDGEPQSRHVASIGKLRDIRFMSIFRFKVWWTTHWVGSKGSDIENETQIIILENSGSGRPYVLLLPLLEGSFRSSFQPGEDDDVAVCVESGSTQVTGSEFRQAVYVHAGDDPFKLVKDAMKVVRVHLNTFKLLEEKTPPGIVDKFGWCTWDAFYLTVNPEGVHKGVKCLVDGGCPPGLVLIDDGWQSIAHDSDDIDVEGMSCTVAGEQMPCRLLKFQENFKFRDYVSPKGKNEVGMKAFVRDLKDEFSTVDYIYVWHALCGYWGGLRPGAPTLPPSTIVRPELSPGLKLTMQDLAVDKIVDTGIGFVSPDMANEFYEGLHSHLQNVGIDGVKVDVIHILEMLCEKYGGRVDLAKAYFKALTSSVNKHFDGNAVIASMEHCNDFMFLGTEAISLGRVGDDFWCTDPSGDINGTYWLQGCHMVHCAYNSLWMGNFIQPDWDMFQSTHPCAEFHAASRAISGGPIYISDCVGQHDFDLLRRLVLPDGSILRCEYYALPTRDRLFEDPLHDGKTMLKIWNLNKYTGIIGAFNCQGGGWCRETRRNQCFSQCVNTLTATTNPNDVEWNSGNNPISIENVEEFALFLSQSKKLVLSGQNDDLEITLEPFKFELITVSPVVTIEGSSVQFAPIGLVNMLNTSGAIRSLVYHEESVEIGVRGAGELRVYASKKPVSCKIDGEDVEFGYEESMVMVQVPWSAPEGLSSIKYLF
The following text describes a protein:
Function:
Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity). Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation (By similarity). Fc-binding subunit that associates with FCER1G adapter to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapter with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation (By similarity). Mediates enhanced ADCC in response to afucosylated IgGs.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MWQLLSPTALLLLVSVPGTHAEDPPKSVVILDPPWDRLLEKDSVTLKCQGAYPPRDDSTEWRWNGTLISNKASSYSITDATVGNSGEYTCKTGLSAQSDPLRLEVYKGWLLLQAPRWVVQEGESIRLRCHTWKNITIQKVQYFQNGMGKKFSHQNFEYHIPNATLKDGGSYFCRGIIKNYDLSSEPVKVTVQGSKSPSPILSFFLPWHQIIFCLVMGFLFAVDTGLYFSVRKVLRSSKEDWRNGKVTWSRDPADKGG
The following text describes a protein:
Function:
Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MQPRSFKPVKSGDSRQKYMILTVTILALCLPSPGNAQQQCTNGFDLDRPSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSNPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGIHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCILQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPRDIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF
The following text describes a protein:
Function:
Plays a role in the cellular response to oxidative stress by promoting DNA repair mechanisms such as base excision repair and possibly homologous recombination repair. Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Likely to initiate repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends (By similarity). Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Has apurinic endonuclease and double-stranded DNA 3'-exonuclease activities and carries out single-stranded DNA renaturation in a Mg(2+)-dependent manner. Activity is more efficient in purine-rich regions of dsDNA than in pyrimidine-rich regions.
Subcellular Localization:
Nucleus.
Sequence:
MPRVKAVKKQAEALASEPTDPTPNANGNGVDENADSAAEELKVPAKGKPRARKATKTAVSAENSEEVEPQKAPTAAARGKKKQPKDTDENGQMEVVAKPKGRAKKATAEAEPEPKVDLPAGKATKPRAKKEPTPAPDEVTSSPPKGRAKAEKPTNAQAKGRKRKELPAEANGGAEEAAEPPKQRARKEAVPTLKEQAEPGTISKEKVQKAETAAKRARGTKRLADSEIAAALDEPEVDEVPPKAASKRAKKGKMVEPSPETVGDFQSVQEEVESPPKTAAAPKKRAKKTTNGETAVELEPKTKAKPTKQRAKKEGKEPAPGKKQKKSADKENGVVEEEAKPSTETKPAKGRKKAPVKAEDVEDIEEAAEESKPARGRKKAAAKAEEPDVDEESGSKTTKKAKKAETKTTVTLDKDAFALPADKEFNLKICSWNVAGLRAWLKKDGLQLIDLEEPDIFCLQETKCANDQLPEEVTRLPGYHPYWLCMPGGYAGVAIYSKIMPIHVEYGIGNEEFDDVGRMITAEYEKFYLINVYVPNSGRKLVNLEPRMRWEKLFQAYVKKLDALKPVVICGDMNVSHMPIDLENPKNNTKNAGFTQEERDKMTELLGLGFVDTFRHLYPDRKGAYTFWTYMANARARNVGWRLDYCLVSERFVPKVVEHEIRSQCLGSDHCPITIFFNI
The following text describes a protein:
Function:
Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the basolateral plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. May transport either NH4(+) or NH3 ammonia species predominantly mediating an electrogenic NH4(+) transport. May act as a CO2 channel providing for renal acid secretion.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MGGGRPGLRLASLLVVLEASVLGLFGLLVRSGPDRAAASNGTSADGHAQNDDFYRRYPSFQDAHVMIFVGFGFLMSFLQRYGYSAVGFNLLLAACSLQWATLVQGLVEALRHRPLRVLVSVQSMINADFAAGAVLISWGAVLGKVSPVQLLLMAIAEVTIFAANEFVVLHLLGARDGGGSMTIHAFGAYFGLIVSRFLYRPQLAKSRHRARSVYHSDLFAMIGSLFLWIFWPSFNSATAQAGAAQHRSALNTYYALTASTVTTFATSVTVSREGRLDMVHVQNAALAGGVAVGTAAEMMVTPFGALAVGAAAGAVATLGYRFLTPLLESGLRVQDTCGVHNLHGLPGLLGALLGAGVATRAGPDTYGDRLDDVFPLVAGGHRSAWLQGGYQLCGLLVTLATAVVGGSLVGLLLRLPCLVPPPDALCFEDQIYWELPAESEEDAGPRCLEPVLTEDPGLRA
The following text describes a protein:
Function:
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MPKLWLLPYFHTQPLGSTTFPSPTLAFCHSPMPKPWTPPPAPRRTATHQLPLVAEAESADLFGLGVLGVAWRGAAASSAVVEESRAGVARLPVAARLSHQQHVAQVGDVAGGQAQRLDLGQLPIGRLGGDEGAQRREGGVDAVGAVALSRVGRVPLPGLAVQPPGFLAAPPLAGFDAEAVGVQVEGLLVGARALAAVLLVLRQHADLGVQDIRNTVGNIPMEWYQDFPHIGYDLEGKRIYKPIRNKDELDKFLEKMENPDYWRTVQDKMTGADIKLTDEQVDLVHRLQKGQFGDVHFNPYEPAIDFFTHEVMIHPVTNRPADKRSFIPSLIEKEKVSKLVHAIKMGWIKPRKPKEDTPTYYDLWAHEDPNSILGRHKMHVPAPKMKLPGHEESYNPPPEYLLSEEEKLAWEQQEPAERRLNFVPQQYRCLRAVPGYPRFIHERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPKPRDLQPFPTTQALVYRGHSSLVRCLSVSPSGQWLASGSDDGTVRFWEVCTARCMKTLPVGGVVKSIAWNPNPTICLVAVCVEQSVLLVNPCLGDKLLYGATDQVLESYVPPEEERVQPVQWVTATSEEHSRGIRLTVQHSKALKQVTWHGKGDYFATVVADNSNMQVLIHQTSKRWSQNPFRKSKGLVQCVLFHPIRPYFFVATQRYVRVYNLLKQELTKKLMANCKWVSSMAIHPAGDNVICGSYDSKLAWFDLDLSTRPYQLLRHHRKALRSVAFHKHYPLFASGSDDGTVIVCHGMVYNDLLQNPLLVPVKVLKGHTLTMDLGVLDVVFHPTQPWVFSSGADGTVRLYT