lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAAEAGGVFHRARGRTLAAFPAEKESEWKGPFYFILGADPQFGLIKAWSTGDCDNGGDEWEQEIRLTEQAVQAINKLNPKPKFFVLCGDLIHAMPGKPWRTEQTEDLKRVLRAVDRAIPLVLVSGNHDIGNTPTAETVEEFCRTWGDDYFSFWVGGVLFLVLNSQFYENPSKCPSLKQAQDQWLDEQLSIARQRHCQHAIVFQHIPLFLESIDEDDDYYFNLSKSTRKKLADKFIHAGVKVVFSGHYHRNAGGTYQNLDMVVSSAIGCQLGRDPHGLRVVVVTAEKIVHRYYSLDELSEKGIEDDLMDLIKKK
The following text describes a protein:
Function:
Catalyzes the formation of the 5-9-5 ring skeleton (3S,6S,11R,14S)-tsukubadiene from geranylgeranyl diphosphate (GGPP) via a 1,11-cyclization and a 10Re,14Re-cyclization.
Domain:
The Asp-Asp-Xaa-Xaa-Xaa-Glu (DDXXXE) and Ser-Xaa-Xaa-Xaa-Ser-Xaa-Xaa-Xaa-Glu (SSE) motifs are important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MIEVPPFWCPLPIAIHPAADQAEKDARAWAERYGVRLRIADQVQPGRLGAYWAPHGTYEGMLAVGCWNFWAFAFDDHLDEPLPLDVPVTTSLVQQAVDIPSPPITDDPWAAGAQAVFNMFRDLATPTQVRYCADNHRRWLHGACWRHSNHVNRRLPPLAEYIPLRMQDAAAQATCLIAVLIGSDISVPEQEMDSPRVRALLETASWTATIDSDLHSFQLEDTQRPVSQHIVSVLMHERGIGVDEALRQSVALRDRFMTRFLHLQQECARTGSSELARFAHTLGYVISGYLQWAVDTSRYGQTEATFSFTDTPRDDTPEPPPGIPSVEWLWTL
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MKVARFEHIPNGENEKMIPVLTSKKASELPVNEVASILQADLQNGLKKCEVCHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGRLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKLTTPQPAATNGDLTSRSNIAFMGTLVRCGKAKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLQGKHILDMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLRAEVTGVGYNQFGEVTVDGDVVHGFYNPAVSRVVEAGCVCNDAVIRNSTLMGKPTEGALIALAMKMGLDGIQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDKPEICFMKGAYEQVIRYCTTFSSKGQTVALTQQQRDLYQQEKACMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKNSQSVSGEEVDSMDVQQLSQIAPKVAVFYRASPRHKLKIIKSLQNNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLIIKILVSSVIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNKMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEVIKKVERSREKIQKHGSSSSFLDYTLTI
The following text describes a protein:
Function:
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain. At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS).
Domain:
GRAM domain binds phosphatidylserine in the PM and mediates protein recruitment to endoplasmic reticulum-plasma membrane contact sites (EPCS) in response to excess cholesterol in the PM; VASt (VAD1 Analog of StAR-related lipid transfer) domain, also known as ASTER (Greek for star) domain is a sterol-binding domain.
Sequence:
MEGALTARQIVNEGDSSLATELQEEPEESPGPVVDENIVSAKKQGQSTHNWSGDWSFWISSSTYKDRNEEYRQQFTHLPDSEKLIADYACALQKDILVQGRLYLSEKWLCFYSNIFRWETTISIALKNITFMTKEKTARLIPNAIQIITEGEKFFFTSFGARDRSYLIIFRLWQNVLLDKSLTRQEFWQLLQQNYGTELGLNAEEMEHLLSVEENVQPRSPGRSSVDDAGERDEKFSKAVSFTQESVSRASETEPLDGNSPKRGLGKEDSQSERNVRKSPSLASEKRISRAPSKSLDLNKNEYLSLDKSSTSDSVDEENIPEKDLQGRLYINRVFHISAERMFELLFTSSHFMQRFANSRNIIDVVSTPWTVESGGNQLRTMTYTIVLSNPLTGKYTAATEKQTLYKESREAQFYLVDSEVLTHDVPYHDYFYTLNRYCIVRSAKQRCRLRVSTDLKYRKQPWGLIKSLIEKNSWSSLESYFKKLESDLLMEESVLSQSIEDAGKHSSLRRRRRTLNRTAEPVPKLSSQRSSTDLGFEAKVDVTGKRKTVDSYDTALIVVMSIFLLLLVLLNVTLFLKLSKIEHATQSFYQLHLQGEKSLNLVSDRFSRTENIQKNKDQAHRLKGVLQDSIVMLEQLKSSLIMLQKTFDLLNKNKSGVAVES
The following text describes a protein:
Function:
Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIITPVSNEIISMVSQNKTLKFTEEVALQILLLCQSGVGTVGNVILFLHNFVLVLTDSQLKPNHVILSNFAVANIFILFLLTFTNTMAVWAPRKPPKNLTCKLTYFFYMVARSTNMCSTCALSIYQFVTLVPGNLTRVMLREISPKVMKYSCYSCWLFSVLNNAYIPMNVSGPQKTNNDTDPTGKWVCSISGFSVGMSFLRFVQDTIFISTMVWTTVSMVIHLNRHHQRICYIHNPSKDHRGYAETRAANTILMLVVTFVTFYLLDCICTFFHISFVDTRFWLRHVKEILTVSFPTISPLILIFRNPRGPCPVPFVVELQSHVTGVASLEQE
The following text describes a protein:
Function:
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Atypical expression also suggests nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that it has chemosensory roles in the detection of internal ligands.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAFKLWERFSQADNVFQALRPLTFISLLGLAPFRLNLNPRKEVQTSKFSFFAGIVHFLFFVLCFGISVKEGDSIIGYFFQTNITRFSDGTLRLTGILAMSTIFGFAMFKRQRLVSIIQNNIVVDEIFVRLGMKLDYRRILLSSFLISLGMLLFNVIYLCVSYSLLVSATISPSFVTFTTFALPHINISLMVFKFLCTTDLARSRFSMLNEILQDILDAHIEQLSALELSPMHSVVNHRRYSHRLRNLISTPMKRYSVTSVIRLNPEYAIKQVSNIHNLLCDICQTIEEYFTYPLLGIIAISFLFILFDDFYILEAILNPKRLDVFEADEFFAFFLMQLIWYIVIIVLIVEGSSRTILHSSYTAAIVHKILNITDDPELRDRLFRLSLQLSHRKVLFTAAGLFRLDRTLIFTITGAATCYLIILIQFRFTHHMDDTSSNSTNNLHSIHLGD
The following text describes a protein:
Function:
As part of the small subunit (SSU) processome, it plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity). Activates BMS1 by promoting GDP/GTP exchange (By similarity). Does not have cyclase activity (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MASQAHSLSYSGCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKVTNGSRIEINQTGTTLYYQPGLLYGGSMEHDCSVLRGIGYYLESLLCLAPFMKHPLRIVLRGVTNDQVDPSVDVLKATALPLLKQFGIDGESFELKVVRRGMPPGGGGEVFFSCPVRKVLKPIQLIDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGINSGKSPGFGLSLVAETTNGTFLSAELASNPQGQGAAMLPEDLGRNCARLLLEEIYRGGCVDSTNQSLALLLMTLGQQDVSKVLLGPLSPYTIEFLRHLKSFFQIMFKIETKPCGEELKGGDKVLMTCVGIGFSNLSKTLK
The following text describes a protein:
Function:
Required for nuclear and mitochondrial iron-sulfur protein biosynthesis.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MSQKSVVLHLYRSLVRESKKFSSYNFREYSLRRVSVGFRENKNKDQNETKELIQDALKNLEMVKRQAFINSMYSTNKLVVE
The following text describes a protein:
Function:
Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
MVIKDLSPHNNSLRKKYLDLIDYGNKNPLTVDPNLYQLRKTILLEGLPPETEEEIEDRTKQDGSKCSLRGMIWKILLGVDKIQPDKYIELIEKGPSNRYQKIRKDIGRTFNRDSQFSQAVSQDQLSRCLNAFAHQCEELGYVQGMNAICGTFLYVLPEVEAFQCFYSLLTQCCPNYFTSNISGVNDASKLLDRILEFVDPELYEYLQNRSYHPLLFTPPILSLGTATPPLDELLKLWDFFLAFGFHLNVICTISQILLMRDVLLVHQSPCLLFRSFPELDAPTIINLSIHIIRQLPDDIYDLLVDHPMTSVDLTPFDRDPNNLNSFNGSGEFDNDNDNDNGNQDEEDDDDDDIDDGHNDYFNDNDE
The following text describes a protein:
Function:
Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso-PC) and N-acylethanolamine lysophospholipids. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine.
Subcellular Localization:
Cytoplasm, perinuclear region. Endoplasmic reticulum. Membrane; Multi-pass membrane protein.
Sequence:
MSLLLYYALPALGSYAMLSIFFLRRPHLLHTPRAPTFRIRLGAHRGGSGELLENTMEAMENSMAQRSDLLELDCQLTRDRVVVVSHDENLCRQSGLNRDVGSLDFEDLPLYKEKLEVYFSPGHFAHGSDRRMVRLEDLFQRFPRTPMSVEIKGKNEELIREIAGLVRRYDRNEITIWASEKSSVMKKCKAANPEMPLSFTISRGFWVLLSYYLGLLPFIPIPEKFFFCFLPNIINRTYFPFSCSCLNQLLAVVSKWLIMRKSLIRHLEERGVQVVFWCLNEESDFEAAFSVGATGVMTDYPTALRHYLDNHGPAARTS
The following text describes a protein:
Function:
May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.
Subcellular Localization:
Early endosome membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MGLWRSWRRSRVRKSIRYFGIFPSRADVRYWDIEQQPLWKKCPTVSKRELPQTDLFREEAAHLFHAGEQKPDFAKPPVNEPRESEQFLMQAPPGNPLLLPHTLQELLSKDSVQVELIPEKKGLFLKHVEYEVSSKRFKCSVYRRYNDFVVFHEMLLQKFPYRMVPALPPKRMLGADREFIESRRRALKRFINLVARHPPFSEDVLLKLFLSFSGSDVQNKLRELVQGVGDEFLTCRLATQAKDFLPADIQAQFAASRELIRNIYNSFYKLRDRAERIASRAIDNASDLLIFGKELSALGSDTTPLPSWAALNNSTWGTLKQALKGLSVEFALLADKAVQQGKQEENDVVEKLNLFLDLLQSYKDLCERHEKGVLHKHQRALHKYSMMKKQMMSATVQNKEPESVEQLESRIVEQENAILTMELRNYFSLYCLHQETQLIHIYLPLTSHILGAFVNSQIQGHKEMSKVWNELKPKLSCLFVGSSNMPTPPLSPPDGNFFSN
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Membrane.
Sequence:
MITQPKPWFEASVLIPILVFFISGFLAPSSKGPEKLSSYESGIEPIGDAWLQFRIRYYMFALVFVVFDVETVFLYPWAMSFDLHRRVLRFRKNSSCSGPQAKGFSF
The following text describes a protein:
Function:
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism.
Miscellaneous:
MISCELLANEOUS: Contains 2 potassium ions bound at each subunit interface. The second potassium binding site is not conserved and not observed in crystal structures of IMPDHs from other organisms.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKYYNEPCHTFNEYLLIPGLSTVDCIPSNVNLSTPLVKFQKGQQSEINLKIPLVSAIMQSVSGEKMAIALAREGGISFIFGSQSIESQAAMVHAVKNFKAGFVVSDSNVKPDQTFADVLAISQRTTHNTVAVTDDGTPHGVLLGLVTQRDYPIDLTQTETKVSDMMTPFSKLVTAHQDTKLSEANKIIWEKKLNALPIIDDDQHLRYIVFRKDYDRSQVCHNELVDSQKRYLVGAGINTRDFRERVPALVEAGADVLCIDSSDGFSEWQKITIGWIREKYGDKVKVGAGNIVDGEGFRYLADAGADFIKIGIGGGSICITREQKGIGRGQATAVIDVVAERNKYFEETGIYIPVCSDGGIVYDYHMTLALAMGADFIMLGRYFARFEESPTRKVTINGSVMKEYWGEGSSRARNWQRYDLGGKQKLSFEEGVDSYVPYAGKLKDNVEASLNKVKSTMCNCGALTIPQLQSKAKITLVSSVSIVEGGAHDVIVKDRINDYHPK
The following text describes a protein:
Function:
Core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol I active site to monitor transcription fidelity and cleave mis-incorporated 5'-ribonucleotides; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSQAFICETGFCPRCGSIMPSPSSAQTINCIVCNNQISIDSYLGVETKSTITFNAIRSKGVQKIKDDTQHAKGPIIERKCEKCGNNSMTYYTQQTRSADEGQTVFYSCTKCGIISVLFAL
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAKNKKRRSLTSKVEQRSKATEIKNNPFEVKINKQKHNILGRKNKHGKGVPVVSRSKGLQKRNATLLQEYKQRHKSNKFLDKRLGENDPEMSVEDKMMERFTLEKQRNHEKSGMYSLNTDEDLTHYGQSLSSLEKFEEPDLASDDEEGGMIDKKFVAEEHFGGFLTKKKTDEEGKPKTRQEIFEEIIAKSKKDKFNRQSEKEDVVKLTEQLDQDFNDVSQFLAKVKRDKDEERRKPDDYDMSVKELIFDMRAKASDRLKTPEELAKEEKEKLEKMETDRQRRMKGITETEEQENKRRMQYLSADDLNDGFELTRDNRSTLSYRDGVPSFGFDQGESDSEEKEEEGEEEVQEDDEEEEEDDESEEGEEEEEDNASDLDSETDEDDDEDDRTVKEIKSSLKKGNKQSVTKKVSIQEPVEKKKKIEEMMRLAKEELPYTFKAPTCLEELEGVLTGHSPSNQLTIIERMIKCHHPSLSDGNKAKLETLTTCIYQLMGKYVKEGKDLQPQFINGLTKHLYDLTQTCALASGNSLMGIICEKYESFNKETEDRGRSTFPSLDVLLYFKLVSALFPTSDFRHSVVTPTMLFMGAILSQCQVRSCQDVTFGLFICNLFLKNVSLSKRLVPEVMNFLQGILYMASDHESKTAGLVVAPFKQSGRFSKLLRHEGTSEAQLRPVKILDLVTDLEDLDQAEFSTWALGLTCHLLHQFSTLYVDLPSYSEIFSPIYILLQDKELLLNKYHHDVQSLGDEVLSHIEGSRQRTRRVLEVEKKKPAPLKMFEPKIEENYDPTRKYRSSGNKEHDEQQRLKHRHRREMKGAVREIRKDTQFIARQKLKEQKERDDERKEKVMRLHQMLATQEGDFRDIKRKKRKP
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MVMASGRQAALVGGRLLQRQPLNAALKTQTRSFYTIFEKYLEANKRYGWKGTLWKLYNPGDVKFGRLVGEDENGFKYYEDPTEVYGQHRWTEYQVDSWDEVEGTLIPPQWHLWMHHLTDSLPGEGGQDPANWEKEETCSHSDAPYANHLGDHVPYYPNKTLYRSRGYNVGSLATKADEPDQYYLQPGHLRRTRKRQPHYFADVDYNNPDQSDESRAQSLRPADIN
The following text describes a protein:
Function:
Acts as an actin bundling protein.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPAMNLKYKFGLVNSAGRYLTAEKFGGKVNASGATLKARQVWILEQEESSTISYLKAPSGNFLSADKNGNVYCSVEDRTEDADTGFEIELQPDGKWALKNVSHQRYLACNGEELICSESSTSNPSANWTVQLAIHPQVCMKNVQHQRYAHLKTSEEGEDSVVVDELVPWGADSTLTLVYLGKGKYGLEAFNGKFVQTDGQLAGTANEQTQFTLIFTSGHLVLRDNNGRHLGVDSGTRVLKSSKPGLTKANYFILEDSCPQGAFEFGGKYASLKQGEDVSFKLLVDEDIEDTETFQLEFVETDKYAIRVCDPKKNSRDAKFWKTVAAGIQANGNSKDQTDCQFSVEYNGNDMHVRAPGGKYVSVRDNGHLFLQDSPKDFIFRLLNRPKLVLKCPHGFVGMKEGKAEVACNRSNFDVFTVTYKEGGYTIQDSCGKYWSCDDSSRIVLGEAAGTFFFEFHELSKFAIRAESNGMLIKGEQSGLFTANGSEVSKDTLWEF
The following text describes a protein:
Function:
Functions in nuclear protein import.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAENPGLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFINPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPSLIPEATQGGTYNFDPTANLQTKEFNF
The following text describes a protein:
Function:
Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. Is a regulator of actin nucleation and elongation, filopodia formation and podocyte migration (By similarity).
Domain:
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Sequence:
MALRKRSPHGLGFLCCFGGSDLPEIDLRDSHPLQYLEFSGPIPNPEELNVRFAELVDELDLTDKNREAVFALPPEKKWQIYCSKRKEQEDPNKLATSWPEYYIDRINAMAAMQNLYETEDEETDKRNQVVEDLKTALRTQPMRFVTRFIDLEGLTCLLNFLRGMDHTTCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISIIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQAYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKHTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELMSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVARHNESSTGPVSSPPPPGGPLTLSSSRTTNDLPPPPPPLPFDSCPPPPAPPLPPGGPPIPPGAPPCFSSGPPPSHDPFSSNEAPLRKKRIPQPSHPLKSFNWVKLNEERVSGTVWNEIDDSQVFRILDLEDFEKMFSAYQRHQACMQEGPQRERGNVRDGGAASRPLPAVEASAHRTEKASRSMVSATGAKKELGSTEDIYITSRKVKELSVIDGRRAQNCIILLSKLKLSNDEIRQAILRMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELTLSQRLKQMLEVVLAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELKHLSEAAKVNLAELEKEVSILRRGLRAVEVELEYQRHQARDPNDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALTHFGEQESKMQPDEFFGIFDTFLQAFLEARQDLEAMRRRKEEDERRARMEFMLKEQREKERWQRQRKVLAGGALEESGEFDDLVSALRSGEVFDKDLSKFKRNRKRPGSQVPEVTRERAINRLNY
The following text describes a protein:
Function:
Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.
Miscellaneous:
MISCELLANEOUS: In a mouse model of Angelman syndrome where Ube3a levels are reduced, levels of Arhgef15 are significantly increased and ubiquitination is reduced compared to wild-type litter mates.
Subcellular Localization:
Cell projection, dendrite. Note=Expressed exclusively in dendrites of the developing hippocampus.
Sequence:
MSAQSLPAATPPTLKPPRIIRPRPPSRHRAPHSPGPLHNGSSPKALPQISNDASASVCTSIFWEPPTASLKPPALLPPSVSRTSLDSQTSPDSPSSTPSPSPVSRRSISPEPAPCSPVPPPKPSGSSRTPLPSGPTPLQDGSASAPGTVRRLAGKFEWGAEGKAQSSDSLERCSQGSTEVNGEKETPEAALSGNGSQENGTPDAALACPPCCPCVCHVAKPGLELRWVPVGSSEDILRIPCRASPLRASRSRINPPVISHPPVVLTSYRSTAERKLLPPLKPPKPTKVRQDISTSEELPQPDLKLPSEDGIQTATKAWEGDRPEGAPLNAPPVALEGREEEGLDGLKGLQWELPLQDEPLYQTYRAAVLSEELWGVGEDGGPSPANPGEAPTFSRLPGPRNTLWQELPAVRGSGLLESLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQSVSERFLGTLLSRVRSSPHITDLCDVVHAHAVGPFFVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILSQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLELQGELTELGCRRGGVLFTSRPRFTPLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSGPPTFRLSLLSNHQGRPTHRLLQAASLSDMQRWLGAFPTPGPLPCSPDTIYEDCECSQELCSEPSTPSKTEGQSLESKAPRKHLHKNPEGWLKGLPGAFPAQLVCEVTGEHERRKHLRQHQKLLEAVGPSSGTPDTPQP
The following text describes a protein:
Function:
Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, cilium. Note=Localizes exclusively to the sensory ending, known as cilium, in AFD neurons.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MLKTLLFILIFFNIPIIAIEEIPDIKENGEKSSYTQFDNGAKLEVNKEHKRVIKIGHIGAVGVMPNDARILNISKENLIEEGLVGDDIEFEIVSRQACSESFEGVAVAAELYHVHQVRAFIGPYCAAELEAVTKMATFWNIPIISYSSVPNAVSDRSVYKTLARVSSKNTNSIAEATVALLLHYKWLKVAIATNTGSTAFERVSIFEEIMHREGVTIVKKVMFDENTDANEMMNSGQLGDLAANARIIICLFSSTKELSKEFMQATYTMRMNNAEYAYIIPWLQSGTKDLTPWIGADGEMLQRVKDHYANAIIVDDVNGFDDSVVSSFVEKIEKHGMQKSDIDVTNINGYLHLFDSLKLYALAIRKVLNETDNEAYVTNGQFIWNRMRRMKFEGVVSRSSSEENKDAGAIGTVLMDDVADRAPIFSAFYISPNRDKVMKMVNMESELISNCDGLKNKSGCFQLKINDIKSGFWPSEDGSMPLDEPICGYRGQRCSYLLEISVGSLIILLILISVVFFFLFRYCENKQLEKMPWRIFHDDLQFIDEEQVKSMMSVGSVTTKLSNIQTGQKQHAIIGVNTHTTYHRYKQRRPIKFIKEDMQLLTQMKQAVHDNLNPFLGAAFNEKEEMLVLWKFCSRGTIQDIIYNANVVLDEKFHGAFVRDITLGLEYLHASPIGYHGSLTPWCCLIDRNWMVKLSDYGIANPLERWEKQGAIEIAAAKDSDDKSQASQATSIIYMAPELLKNRETNKRRGMDQSWVKQSMLRRQAGDIYSFGMVMYEILFRSLPFRDNTNISELVDYLADGSKTVSPEIQNQMGLHPDLNALLRDCWSENPEIRPSIRRVRLNTEMVLKTKGSLVDQMMKMMEQYANNLEKLVAERTGMLEEANIRADQLLTQLLPAYVANELKMGRSVAPKLYSSATILFSDIVGFTTICSGSTPLEVVNMLNGLYTGFDECITRNKSYKVETIGDAYMVVSGIPEENEYNHSRNIANTALDMRQYLTGYQIPHRPTHRVRCRWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQMSEEAHMHIRAHHPVFTTTERGEVQVKGKGTCRTFWLEDRVGDASTTNYIQNVEGV
The following text describes a protein:
Function:
Transcription factor (By similarity). Involved in modulating innate immune response pathways, acting to promote resistance against infection by Gram-negative bacterium P.aeruginosa strain PA14. May act as part of a feedback regulatory loop with the pmk-1/p38 MAPK pathway. May also function in concert with CCAAT/enhancer-binding protein cebp-2 to mediate immune responses, independently of the pmk-1/p38 MAPK pathway.
Subcellular Localization:
Nucleus.
Sequence:
MWPPNAENNHCNYSYHEHAELNPHDHYHHHHYPHSSVHHTECYQTLSCPSDLPVETSYYNSVPPSYQDLGQTDLSPQFWCAEVDCVHERCSTKEIPHEQSKIFEEISKECDHIMNSAGDCEKCQVEHENGAQEAIPINDLVDIVMQTVDNLKKEGSSNDETKLLSRKRQQNKVAAARYRDKQKAKWQDLLDQLEAEEDRNQRLKLQAGHLEKEVAEMRQAFLAKLAKK
The following text describes a protein:
Function:
May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.
Subcellular Localization:
Secreted.
Sequence:
MYWFRQVYRPSFFFGFLAILLLSSPTPSDASIRLCGSRLTTTLLAVCRNQLCTGLTAFKRSADQSYAPTTRDLFHIHHQQKRGGIATECCEKRCSFAYLKTFCCNQDDN
The following text describes a protein:
Function:
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MSNRPESSISMEFREFYCVGDTPKKEEDPTDINSSIFNAKLLFDKSTKTLSIHQLVAQEISLVADIESLDNDMQTLVYDNYTKFLNASDLVITFGDNISVLESQVSDLSNTLTKVASHNENISSGLHENREKIQRLIGIQRLLERIKFISRLPSILKSNLQKKNFNTAVKIWIKVEKILRTQQRFPSFSQIYEESTEIMKEIKNKITEQMLTSDITVENSVNDGVLLVQLGTSLILICSQLIHHQFLIVDNAIDEIELEDEPFTALSHLNESIIDHTSKFITLYKYNLIPLSPDEETKTKAETILTGFANKFFERILPILPSAKLSDLDSKKLAAYIRLFIDLFNVVVNESTIQQNIHKIIKNYTNQRVQKIFNSAFEIIENDDSSQLIGHFTSSFLSSIDTIVNEFEILSMLEHKECTQMLVQNFRLQLSNFSESVKNCPLEKSLLVAIISENMANDMIVKILAVLSRIDNDIPQSVLARELRTTFLSSSLVNVQRFIKYKRLAVEPIVLTFYDSEILERKKTTNEISKKSLDLVKEINEIWQTLDNFLPKVTEKSGSTSSHILYNTPIQPNFDGVRDETYNHIDRLFTSVNRLGLSKSVGLNKISIFSSIVIYTMKTILEIVRDSTFTSPAFNQVQVDMFYIYKSFNERVDNQDLFSTIIEEIVNSAADRTFNIEPFELAVIKKIVEEQPSVLTK
The following text describes a protein:
Function:
The apo- but not holo-form probably binds DNA (By similarity). Acts as a transcriptional regulator. Probably redox-responsive. Upon overproduction at least 10 other genes are up-regulated, among them are Rv1258c, Rv1988, Rv2301, Rv2416c, Rv2725c and whiB7 itself. Probably redox-responsive. The apo-form has been shown to act as a protein disulfide reductase.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVLTVPRQTPRQRLPVLPCHVGDPDLWFADTPAGLEVAKTLCVSCPIRRQCLAAALQRAEPWGVWGGEIFDQGSIVSHKRPRGRPRKDAVA