lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the modification of secondary bile acids into iso-bile acids (3beta-bile acids) via epimerization of the 3-OH group through a 3-oxo-intermediate. Catalyzes the oxidation of deoxycholate (DCA) and lithocholate (LCA) to yield 12-alpha-hydroxy-3-oxo-5-beta-cholan-24-oate (3-oxo-DCA) and 3-oxo-5-beta-cholan-24-oate (3-oxo-LCA), respectively. Is also able to catalyze the oxidation of cholate (CA) and chenodeoxycholate (CDCA) into 3-dehydrocholate (3-oxo-CA) and 7-alpha-hydroxy-3-oxo-5-beta-cholan-24-oate (3-oxo-CDCA), respectively. Can also catalyze the reverse reactions in vitro. Prefers NADH to NADPH as cosubstrate. The conversion of the abundant bile acid DCA into isoDCA by the gut bacterium E.lenta favors the growth of the keystone commensal genus Bacteroides, since isoDCA is less cytotoxic than its parent compound, DCA; iso-bile acids have thus a potential role in modulating gut community composition.
Sequence:
MGIYVITGATSGIGAKTAEILRERGHEVVNIDLNGGDINANLATKEGRAGAIAELHERFPEGIDAMICNAGVSGGKVPISLIISLNYFGATEMARGVFDLLEKKGGSCVVTSSNSIAQGAARMDVAGMLNNHADEDRILELVKDVDPAIGHVYYASTKYALARWVRRMSPDWGSRGVRLNAIAPGNVRTAMTANMLPEQRAAMEAIPVPTHFGEEPLMDPVEIANAMAFIASPEASGINGVVLFVDGGTDALLNSEKVY
The following text describes a protein:
Function:
Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide.
Subcellular Localization:
Cell junction. Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane.
Sequence:
MAPEMDQFYRSTMAIYKSIMEQFNPALENLVYLGNNYLRAFHALSEAAEVYFNAIQKIGEQALQSSTSQILGEILVQMSDTQRHLNSDLEVVVQTFHGDLLQHMEKNTKLDMQFIKDSRQHYEMEYRHRAANLEKCMSELWRMERKRDKNAREMKESVNRLHAQMQAFVSESQRAAELEEKRRYRFLAEKHLLLSNTFLQFFGRARGMLQNRVLLWKEQSEASRSPSRAHSPGLLGPVLGPPYPSGRLTPTRLDMPQRPLGEFGSPRSRHGSGSYGPEPTEARSLPRTPSASSLYGSSTQRSRSNSFGERPGGGGGGGGARRVRALVSHSEGANHTLLRFSAGDVVEVLVPEAQNGWLYGKLEGSSTSGWFPEAYVKPLEELPMNPMKPLNPVTSMKPMNAVNPVASTNPVSPMNALPSRSYPLRGSQSLDDLLDRPGNSTAPSEYWDGQSRSRTPSGVPSRTPSPVPTPLPGSRRGSMGSMGAASDGKKLTSWEQQPPELFPRGTNPFATVKLRPTVTNDRSAPLIR
The following text describes a protein:
Function:
Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MGWVTDWSAQAACRTTDPDELFVQGAAQNRAKAVCTGCPVRTECLADALDNRVEFGVWGGMTERERRALLRRRPTVTSWRRLLETARTEYERGVGIVPLDDDEVYENYAAVG
The following text describes a protein:
Function:
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm. Cytoplasm, P-body.
Sequence:
MSTNNSTQQQDELDQIKSKIQDNLISSGNYDIINKQLKLQLYESGWYDKVSQIASRELMDHQQEVNSSNSNSSNSNKKNELTFDQLFAFVKPKAEELVPNEVKQDILNRITKYLDDIIQ
The following text describes a protein:
Function:
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, myofibril. Cytoplasm, cytoskeleton, stress fiber. Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle).
Domain:
The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form.
Sequence:
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV
The following text describes a protein:
Function:
Part of a potassium transport system.
Sequence:
MPQLKRFVIAGGGQVGLQAAGNLSSLGHDVVLIEPDEQRVAELSDAYVGPVIHGDATRPSILTQADLDDADAIAALTDDTSANLAICMEAQHLNPAIQTLARADTQCNEEYEEVVDATLLPKYLGGDYAADMLTGEDVRTLVYPTSDLDIIEISVAESAPVAGRRLDEIALPEGSLLISTADREHLAGPEMVLEPERRYVLAVEADVADEVRDLMRG
The following text describes a protein:
Function:
Lytic polysaccharide monooxygenase (LPMO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate (Probable). Shows activity on beta-glucan and amorphous cellulose. Does not show beta-1-3-glucanase, beta-1,6-glucanase, mannanase, xylanase, beta-1,3-galactosidase, amylase, pectinase, nor chitinase activities.
Subcellular Localization:
Secreted.
Domain:
Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM). The linker forms an integral part of the catalytic domain structure, covering a hydrophobic patch on the catalytic module. The CBM domain is essential for binding to and subsequent oxidative degradation of polysaccharide substrate.
Sequence:
MIQKLSNLLVTALAVATGVVGHGHINDIVINGVWYQAYDPTTFPYESNPPIVVGWTAADLDNGFVSPDAYQNPDIICHKNATNAKGHASVKAGDTILFQWVPVPWPHPGPIVDYLANCNGDCETVDKTTLEFFKIDGVGLLSGGDPGTWASDVLISNNNTWVVKIPDNLAPGNYVLRHEIIALHSAGQANGAQNYPQCFNIAVSGSGSLQPSGVLGTDLYHATDPGVLINIYTSPLNYIIPGPTVVSGLPTSVAQGSSAATATASATVPGGGSGPTSRTTTTARTTQASSRPSSTPPATTSAPAGGPTQTLYGQCGGSGYSGPTRCAPPATCSTLNPYYAQCLN
The following text describes a protein:
Function:
Plays an important role in pancreatic tumor progression and metastasis. Promotes pancreatic cancer cells migration and invasion through the TLR4/MyD88/NF-kaapaB signaling pathway, without the involvement of the TLR4/TRIF pathway.
Subcellular Localization:
Secreted. Cytoplasm. Cell membrane. Apicolateral cell membrane. Note=Co-localizes with TLR4 at the cell membrane of pancreatic cancer cells.
Sequence:
MLLLLTLALLGGPTWAGKMYGPGGGKYFSTTEDYDHEITGLRVSVGLLLVKSVQVKLGDSWDVKLGALGGNTQEVTLQPGEYITKVFVAFQAFLRGMVMYTSKDRYFYFGKLDGQISSAYPSQEGQVLVGIYGQYQLLGIKSIGFEWNYPLEEPTTEPPVNLTYSANSPVGR
The following text describes a protein:
Function:
Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). It is also able of sustaining the biosynthetic pathway of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs) (By similarity).
Sequence:
MSEALLNAGRQTLMLELQEASRLPERLGDDFVRAANIILHCEGKVVVSGIGKSGHIGKKIAATLASTGTPAFFVHPAEALHGDLGMIESRDVMLFISYSGGAKELDLIIPRLEDKSIALLAMTGKPTSPLGLAAKAVLDISVEREACPMHLAPTSSTVNTLMMGDALAMAVMQARGFNEEDFARSHPAGALGARLLNKVHHLMRRDDAIPQVALTASVMDAMLELSRTGLGLVAVCDAQQQVQGVFTDGDLRRWLVGGGALTTPVNEAMTVGGTTLQSQSRAIDAKEILMKRKITAAPVVDENGKLTGAINLQDFYQAGII
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagella axoneme.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, flagellum axoneme. Note=Present in the germ cell lineage at all stages.
Sequence:
MSGVVFPGQAPVDLDIYQSSYMIDYKPYGKHKYARVTSEVQAKLDTQLRDKEFYRPTPSPNPKLEDGYPAFKRPHMTAKDLGQPGFFPPQGRVGPVEDEWRFTSTCPSVYPASHALYLAHGDPNRIQQSADFPCLLEPEHQPAPDVGKGYFLLPGCACTYHCTVKVPILNRWGPLMPFYQ
The following text describes a protein:
Function:
Component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MHSHRQKWGRQTDIARVLDDIEHDLYLPQRLSLDGATGTDESHVQYGIVKDCSVLTCGCCISESLFNDLCRETSNKQTACPICQRENVRLLSAIKPLRDLARQIDFFRSTTGQGESESDELPAIVKTSPSSSSLSLTPSRSSSTAGLEADNKTLSDPTVKEKSSLLELFHIVASKMHNANTEVGSDHPLTTGTTRDQEEHTTKENYSSSLLEPNYDDHANWKILDNASNTRTVPIDNNFSLMSTDVTIPSTANYQTNSAHDLDEEKEYFFANCFPMYRKKFQFNTHPKFLGTKSKLFINQSISPDCTKFALITEHKWEIYSINPKDNSPQLVSCGKSSGEYGPNFNQLTEQSSSSLSTTSQASKKKKKNWSQRFCKLSNDFLIISGSQNILNVHDIHQNGKLIYTYVSRFPIRCIDIDPRSQIIAYGITGKDRHTGAEQALVVIQQITRNKVTLEPEFPPPITITLPYRDPINTIQLSHDAKYLTCSTALESRFLIISLQKINEPRLIMKSVRSIDTSLESEGITDTKLFPGNPNLMCITSTAFNSSPLVINTKITQINGVRTVAQPSMLIRVDEIGCKIHKCEISPRNDAIAFLDRNGSVYIMCAPTMMDNNEKRRTILVETVANAYRAYESATLRFNPEGNKLYILDRKGTFFVEDFAYGLPQSREITKCKQIFHK
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase.
Subcellular Localization:
Nucleus.
Sequence:
MNNQVKPTLSNKAEIINKWLIDNGVRINNKLIKIVYLGKENNFEQTENTTATTTTSERINDSIVSGLGVISLKELKVDDIVAKIPKSIILSIHTSSISNILEKYKIENNIGTSIALIHEASLGEKSKWYGYISSLPRKVDVPILWDSESRKLLKGTAIEDVLNDDDILINQVYADVIESILSKNHPEIFGDKELYSIENFKIANSIISSRAFCVDSYHGDSLVPLADIFNHQTAREHVHIESNGDVCNKCGSIKTCKHRKVVTQHHTVNSTKGKRTHKVAGIPSSKKHIHKGNCCSTTTTKTNEEDKDTIIEEDDEHLYIKVVKGVEANKEVYNTYGDHDNAILLSKYGFLEMDNPCDRLSIDKQLVDKELELIGAENQITRMDLFNRISFYAEMFDIDSRNNHAIENDGRLDDALVCSVGIALAPQSIFQSWKSMSEHKREKYFEQLEAEDIVKQSQLVRNTLLSILNKLFSNYNNSNETTATTTIEQDQEKLSTLKNQREIIAQSLKICEKTLINKSINYYKNL
The following text describes a protein:
Function:
Involved in the integrity functions of RAM, a conserved signaling network that regulates maintenance of polarized growth and daughter-cell-specific transcription.
Subcellular Localization:
Cytoplasm. Bud. Bud neck. Bud tip. Note=Localized to the cortex of small and large buds during bud growth, to the bud neck during mitotic exit and to the tips of mating projections in pheromone-treated cells.
Sequence:
MRSFIKAHKKSTSFDESPKRHSNFSGNTNNSSQRSSDDSLDFLPSTPSQMNYDSIPPPAKHSPGFESFHRLANKTSKLFKKTSNSNLNSHLASTPTTSTNQTTSNSFVLQNPPTKNTGPPPPLPPPLFPSSSTSSFSRHDNESEYTAYKKTSPAKDFNRTTDSLPAIKGTITHSWGDSKVESHVIILNDPASPASNTSEATSSKQFKTPIIGNENLTSTTSPSNLEPAIRILNKNKGKQQENIDDAEDGSSKKEHHVYKALALAKNRNRQARIHSHDDIINLGKASQMDMSLLAAAFSGNSTTTINNDQSSNEQTDEKILDIERVTTTSTLTSSETTSPINKSPCFYSQTLSLSPKIRHGDLQSSPSKVNKNDSQNETLNKKKVRISLNRKEEEKVYSLNNNSDEYSVNEKETHKANDCNDESSENGDGDNDHDDDYDDDDDDDDDDDESEFSFEYAGINVRTSSVKYYSKPEPAANVYIDDLYEDENFDDDMNCIEDDESGNEGNEICGLSTRFEETSLKSNKVKKFNDLFNLSDDDEEEDGKDNSNNGDENESDNLYQKRLENGKETFNGNHGGHHDDASLGETVDNKEQFLINDNVKKPIQKYNDLFDLSDEDDNDDKEMSEAESYMFSDEAPSIESGPANAKSTRGIYSQSNKNIIRDGKPNYSFSLKRNNSDDETEHTSAIKASLTGTTGSTKPTVKSFSDIFNVDDSASDAESDSGTGGNNSNGLVSNDSERQVSLQSSLYETKSESHPPNHPHSQILQTPAKIVITPSVSDAQSQALAITDDDGEDDDDDTSSILRTPFQLIDSSHSQQPHYASPQYTAVLNSPPLPPPARSQSLKYHDLNCDLDSEVPRPMSNLFFIDEAEEDEYNQKSKFFDFDHYDIDEINGIPEDFNFSDSERDDLNRRTLKSPLRGGSKNREVSPFSSVSSSFRSTHSFNGKLTINQGAKELAPMKNKIELTNKTVTFFNSNNWNTYDCNSLSRKTSSQMRDSKYQNHNVGQNVEPSSVLSPQHQISNGLDGKCNDNYVISPNLPTTITPTNSFTKPTPEFSNDYSLSPIQETPSSVQSSPKRA
The following text describes a protein:
Function:
Involved in development during embryogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MPRPSRDSYGDQKPPYSYISLTAMAIWSSPEKMLSLNDIYQFITDRFPYYRTNTQRWQNSLRHNLSFNDCFIKVPRRPDRPGKGAYWTLHPKAFDMFQNGSLLRRRKRFKLHQTDKECLNEEFIALANMNRFFMAQSTGAPTYHHHEHPAAGYYPPLVEPLGGGSSSISPGGMVYAPISPPLSPPDDLAGTPHTGTESPVTVPTLPAVPTATATTTTTVPPKPKRSFTIESLIEPDSSSSSDSEESTDRAQPPYQLQQQHQLEHLRHLSQQQLVSNLTAFNEYAAAVQHHQQQQQHQAAVAAAAAAAAALGTTYAGSVPLHPLLLPLGKMQSPATYFLHSGPAPYHHHHHHPQHHHHHHHLAHLYPGHLSAGSAAAVAAATTNGHPAHHRHPHELGPPSLAIA
The following text describes a protein:
Function:
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, axon.
Sequence:
MSYTLDSLGNPSAYRRVPTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSALAPRLAYSSAMLSSAESSLDFSQSSSLLNGGSGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIHALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRAVRKDIEESSMVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLECHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFSGSITGPLYTHRQPSVTISSKIQKTKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEDALTVIAEELAASAKEEKEEAEEKEEEPEVEKSPVKSPEAKEEEEGEKEEEEEGQEEEEEEDEGVKSDQAEEGGSEKEGSSEKDEGEQEEEGETEAEGEGEEAEAKEEKKTEGKVEEMAIKEEIKVEKPEKAKSPVPKSPVEEVKPKPEAKAGKDEQKEEEKVEEKKEVAKESPKEEKVEKKEEKPKDVPDKKKAESPVKEKAVEEMITITKSVKVSLEKDTKEEKPQQQEKVKEKAEEEGGSEEEVGDKSPQESKKEDIAINGEVEGKEEEEQETQEKGSGQEEEKGVVTNGLDVSPAEEKKGEDRSDDKVVVTKKVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQGD
The following text describes a protein:
Function:
Transcription factor (By similarity). Binds to the iroquois binding site (IBS) motif of target genes to regulate gene expression; functions as a transcriptional activator or repressor (By similarity). In concert with irx5a, plays a role in visual performance.
Subcellular Localization:
Nucleus.
Sequence:
MSFSQFGYPYNATSQFFVSATPSTTCCDSISRSVTEGSSASQTAASFCCPSYENRLLASTRTELNAALGMYGSPYAAAAAAAGQNYANYFPYSADPSAIYSSLNPQYEIKEGSGSLHSTITQPATYYPYDHSLGQYQYDRYGTVDFNGSTRRKNATRETTSTLKTWLYEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPKNKAGDDRKEDLDSKDSKDEQDLQFSDLDDMEDEDCDKLDSDCEKSGQDDLPTSSPPKRDCNPDIPLHSNFPSFPCGLKSLGPLNPDYLDHLGSKPQQQQPSPQSTSINTVALSHFESSEKPRIWSLARTAAAGVVLGTQHVGDVRTGPVDCQMQGVRLPTVGAVQCGELKGLQDPTNLSNTESLFQEGLQGIHKAYSSGSFKTLQLHSSSYPGLTESCQYSSMEGFPSAGKTETESSELSDTCPTIQEAKTTAFRPVMKR
The following text describes a protein:
Function:
Transports cytoplasmic succinate, derived from isocitrate by the action of isocitrate lyase in the cytosol, into the mitochondrial matrix in exchange for fumarate.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSQKKKASHPAINLMAGGTAGLFEALCCHPLDTIKVRMQIYRRVAGIEHVKPPGFIKTGRTIYQKEGFLALYKGLGAVVIGIIPKMAIRFSSYEFYRTLLVNKESGIVSTGNTFVAGVGAGITEAVLVVNPMEVVKIRLQAQHLTPSEPNAGPKYNNAIHAAYTIVKEEGVSALYRGVSLTAARQATNQGANFTVYSKLKEFLQNYHQMDVLPSWETSCIGLISGAIGPFSNAPLDTIKTRLQKDKSISLEKQSGMKKIITIGAQLLKEEGFRALYKGITPRVMRVAPGQAVTFTVYEYVREHLENLGIFKKNDTPKPKPLK
The following text describes a protein:
Function:
Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling in response to DNA damage. Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. As part of 55LCC complex, also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles.
Subcellular Localization:
Nucleus. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.
Sequence:
MEAKTLGTVTPRKPVLSVSARKIKDNAADWHNLILKWETLNDGGFATANSIANMKISLSSKDKIELASSGLASNDCAEKEHPEYSRELETLCEELQATLEGLTKIQMKMEKLSSTTKGVCELEDYHHGEERKRPPLFHTWPTAHFYEVSRKLSDMYSQELRLKRTVVEQLAHTADRDLALSYLSMWLHQPYLEAGSWLLLESMLLETGHRVL
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (By similarity). The NSL complex also acts as a regulator of gene expression in mitochondria (By similarity). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (By similarity). Associates with microtubule ends and contributes to microtubule stability (By similarity).
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Mitochondrion. Cytoplasm, cytoskeleton, spindle pole. Note=Concentrated in the nucleus during interphase, localizes to the spindle poles and pericentriolar region during prometaphase and metaphase, and remains associated with the spindle poles throughout anaphase.
Sequence:
MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILISANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSVPAKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSSSLNGGKRSLTSSSLQGGEVGGPDSGNLKGGMTNCTLPHRSLDIQHTTLYSNNSTANKSSVNSMDQPALQGSSRLSPSTDSSSNLTNVKLEVKKSPLSSILFSALDSDTRITALLRRQADIEIRARRLQKRLQVVQAKQVERHLQHQLGGFLETTLSKLPNLESLRSRSQLMLTRKAEAALRKAASESATSEGLSNFLKSDSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQCHVPLKRRSEWRWAADRAAIVSRWNWLQAHVSDLEYRIRQQTDIYKQIRANKGLIVLGEAPFPDHTTDLLSLSSEVKTDHGRDKLIESVSQPSENHGILVSNITESLSTKSCGAPRPVNGVVNSLQPVLADQVPGDSSDAEEQLHKKQRLNLVSSSDGTCVAARTRPVLTCKKRRLVRPSSIVPLSKKVHRNVRSGCDVNPSCALCGSGSVNTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSLHFQSMLKSQWQNKPFDKIKPTKKFSLKHRATMPCSLSDPVRKDRHKLVNSFLTTAMLKHHTDMSSPSYLTATHHPPHSPLVRQLSTSSDTSTPTSSGSQVAASTSQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDVQSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYRSSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEFSHGQSPRSPISPELHSAPLTPVARDSLRHLASEDTRCSTPELGLDEQSVQPWERRTFPLAYSPQAECEEQLDAQDTAARCTRRTSGSKTGREAEVAPTSPPVVPLKSRHLAATVTAQRPAHR
The following text describes a protein:
Function:
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTSLFGNLLSNPFEDLVDKATSENLPVGTDDIVSNLDIADKIKSKEVSAKTAIQSFKRRINHKNPNVQLLALKLTDTCVKNSGHHFLQEVASREFIDNLVSISRSLMNPNTDVKQKILALIQAWGITFKSKPDLSFVCEIYEAMKKEGVIFPPIDAADTAAAIIDTQTVPDWTDSELCMRCRTAFTTFNRKHHCRNCGKTYCNDCSSKRIPLAHLGITEPVRVCDTCHTKLATKSPANTNDFAKTNSANSTTGLGASSTTSTASSNAHEDLAKKEDEDLAKAIAASLGTTNDSGVSSSASRKSTTKQSVRFATQDQESDEDLKRAIEASLRDAERSTPVQRNSNLYGSPPDHQQQSSLYGSESKSFSERTPTAVAVVDSSNDISPTELENIRLFSELVERTEADILSKGITNLNPAQLQALLTQVSPLQVKLHSSIEVAANKYKTLYDINEQINDAVKLYDQFLKQRLTFSQQQHSSVGIPYGHPYLAGVSSAAGVYASPNTQQQPQKQWGAPAVDSNAASQPYQIPGSLSYPPHATFIPGGSVPGVLQPVQQQPAYPPSHNYGHPPSNLAPGSQYSYGAPSQPESNIALQVSNGVPYQPPPSDAHVAQPQRHTQQPPQPVVQEAPLIEL
The following text describes a protein:
Function:
Involved in disease resistance.
Sequence:
MGVFTFEDEINSPVAPATLYKALVTDADNVIPKALDSFKSVENVEGNGGPGTIKKITFLEDGETKFVLHKIESIDEANLGYSYSVVGGAALPDTAEKITFDSKLVAGPNGGSAGKLTVKYETKGDAEPNQDELKTGKAKADALFKAIEAYLLAHPDYN
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
Subcellular Localization:
Nucleus.
Sequence:
MSRTKKSARRSKCNTDGAAPAPNKKQRKEAAKAVAAAAVPATDNGEKGSRKWAESTLTKLLGGMSLDSFLSEYFEKKPLLVRKAEKGALFGNALFSRKKMLKVMEKQPRSMGFGKDLTVCRYANSERENFDGEDSNGHATSRQVASLLDNGYSCQFYQPQRYVDGLYELNAAFEETFGGLAGASAYLTPANSQALAPHHDDVEVFVLQTQGRKKWKLYHPIVELAGEHSSDLAEDQIGEPWMELTVEEGDLLYFPRGVIHQACTDKEQFSTHVTISVYQHNTWANFLEAALPRVIRHAFDSDVAFRKGLPVGYLKYMGTQFPTDSNKAKEFASMCKELVAKLATHVGEKDLQEASDEAALDVLANRLPPPMESENKTGEEAAPSPLESNTAIRFKNRSHIRLSMGEDAANETFVAVYYSLHNCRRHHMGLCTCDGESGDENGDEDEEDDDAGGAAETSSADGENENDEDGSDDEDDDPSVAFGQMPPQPQSIVFPGELASALMKLYASSASVPGVPIDELAETASDETAVRGMLLRLWSEGLLDVTSQA
The following text describes a protein:
Function:
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTLTELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERNLARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLSDKKTLKWIHKALEQRKEYEEIMRDYIQKHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLRFLESLPEEEQQRVLGEEKMLNINKKQTTSPASKKPSQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMWNDLTEKKKAKYKAREAALKAQSERKPGGEREDRGKLPESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYERELSEMRAPPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQRQYKVHLDLWVKSLSPQDRAAYKEYISNKRKNMTKLRGPNPKSSRTTLQSKSESEEDDDEEEEDDEEEEEEEEDDENGDSSEDGGDSSESSSEDESEDGDENDDDDDDEDDEDDDDEDEDNESEGSSSSSSSSGDSSDSGSN
The following text describes a protein:
Function:
ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes. Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein rlp24 from the pre-ribosomal particles. This step facilitates the subsequent release of other shuttling proteins such as nog1 and allows the transition of the pre-ribosomal particles to later maturation forms that bind SPCC550.15c/REI1.
Subcellular Localization:
Cytoplasm.
Domain:
The first ATP-binding region binds ATP with low affinity whereas the second ATP-binding region binds ATP with high affinity.
Sequence:
MSVAIKFTVKINDGSLRRQQTRHVFLSPAALNRLKLSPSQVIYLKHKGGEAVGITQSVKGNGIGPFEILISPLLAKWANLKAFQRVNISQYVHPLKEAEGIKIVASLSSNNEPIPESLIRKELLEIRYLHPGMIVMGESPMNMAKSGSKNLSSENMATEIFEINSGLSAQSGTEVGSSQSSPSVNESEPKATEDLDELSPGSYKVKEIHIRSPSNLIEAISDMSLDEPRIYKFTAASSMEIETPDLLKLPHEDRTQSAYNQGSEETQNFDGPPSAVTFSSIGGLQAQIAQIRDIVELPFQNPELFKFFNIMPPRGVLLYGPPGTGKTMVMRAVAAEANAQVFTIDGPSVVGKYLGETESRLRKIFEDARAHQPSIIFIDEIDALAPKRTEDVSEAESRAVATLLTLLDGMANAGKVVVIAATNRPNSIDEALRRPGRLEKEIEIGIPDKSARLDIIKLLLSGVPNEINDAQLEDLASRTHAYVGADLAAVVREAALRAIKRTISLQKDTSGLDIFGAVQMDDLEFALSSVRQSAMREFMMESPNVHWSDIGGQEEVKQKLKESVEWPLTHGETFSRLGVRPPKGVLLYGPPGCSKTITAKAIATETGLNFIAVKGPELFDKFVGESERAVRQVFQKARQASPSVIFFDEIDALTANRGEDNSSDRVVAALLNELDGIEALRNVLVLAATNRPDMIDPALMRPGRLDRLLYVGPPNFEARKQIVKIQAEKMKFAEDVDLDLIAEKTEGCSGAEVVALCQEAGLIAMHEDLEAKEICQAHFKTALLALRKAITRDMLEYYASFSESVTSIS