lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the positive regulation of telomere length. Binds RNA non-specifically. Binds specifically single-stranded telomeric DNA. Not required to recruit telomerase to telomeres, but stimulates TER1 RNP repeat addition processivity.
Subcellular Localization:
Nucleus. Chromosome, telomere. Nucleus, nucleolus. Cytoplasm. Note=Localizes to telomeres in S-phase. Localizes to cytoplasmic foci.
Sequence:
MAKKRESPKLIKIKDAIKLINQQVSLIGIVLEQREPKQCRNNDWICTLRIIDDTYPSPGLTVNVFSKTLEQLPQIKNHDDMILFTRIKMQTFDSGERVNAACSRWVSSFALFEGVDFVCYQCSTNFHEEEALYKSAMDDLRKVFAGCSQVIKAMQSISYRTKPCSEVFSFLREIKIGKRFDLVCRILHADEDTSAVFVWDGTDAPPASILAKRSEEDKAFSSLSVHTLLSRDVLLSFPTVGTILRVHLSSHLFYRVKPGDWVKLYHLLCEVDRGSWVIKVTSSTKVHHLAQDDRLVEKIMRIYDKRLSSKLGHISFWCFPSPPGLTETDDNCAPFVTLMDIITFPKVTCKYRCIVRVVAAYPWQVEDFCSDENRRHHQVLLTLEDSTATLEAFLCNKDAEYFWGLGFQDTETLRKKRNWLLGIRESSNFVAPRNPPWIECCILSYYTNKADPWNTRLYRIFGTRLLH
The following text describes a protein:
Function:
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MMDTKVDQTIQPKFYVDKKLSKSFDNKLDEDIFNYPFKKESFLKSEKFSFEHTKDSLWKCIKEKAKKKSDMEYFNCVNNLCCKFICTIRKYVKYFLYLKDSSYEIYNINLYNNNNMNIINNKNITNNKNITNNINNSFSNDYINYNHNYNHLNNSSSSKHNNYNVNNIDEKNIKNDYNTYHNIYEQIFFKYNPSFYEYLMFTLMKKLIHYKNYIFNKTKKINNSYNNNDIKNIDGFLIFQNINFEEIFLNTFYSSFPFKLFLHSLYMIFICFIYFVVLYFMLLKKIYTHPFIFHLSVLKFLFDIIFFLSFILYPLFLRLKRIDKIIYSSYISSYIFVCVTFLYSFIIFKCSSYSVKMNSNTYQNNFVFQNMLFLLINIIYICIFCFLKNYMILYSFLYNCRFSIFCILFIFLYYYLFFSLDFYRIIHLPLDNFFFPFLCFLFFSFLFIFKIIMSLYYEYVYEKKYRILFVKKNNLIEKRITKRKNTNINNAYFTKYFSIDNTIPTSPIEDILNNFKHILETINIIEENPNHNLTTNIMKIKEKIKNCDNILRTKNINQVQIGKYRKFEKVYNIWCLDKMYLNYPLNQEETKSFLSNSLNRISFNSFSNMHSLLSSKFQEHYNDIYDWNGNIENIYKANTFISIGYKLLYPLGVLEANFDKEKLKKFLFRICSYYNDIPYHTSLHAAQVAHFSKSMLFMLDMNHKISAIDEFCLHISSLCHDTGHPGLNNYFLINSENNLALTYNDNSVLENYHCSLLFKTLKNPNYNIFEHYPYHIFISCKKNIIKAILSTDMKNHFEYISDFRTSKEFIDYDNLSNDQIWQIFCLILKASDIGHSTLEWNKHLEWTLKINEEFYLQGLLEKSLNIQNSFLCDINTMNKLALSQIDFLKHLCIPLFNELNYICKNNDVYTHCIQPIENNIERWESHKNDNQNLGLHEKYKEENLLSKLELIKFE
The following text describes a protein:
Function:
Probable nuclear receptor coregulator that can have both coactivator and corepressor functions (By similarity). Important for maintenance of the adult pluripotent stem cell population.
Subcellular Localization:
Nucleus.
Sequence:
MNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPLPYERDSRDMSPYRDSGRDRSPADRERYYKALRRGDSSKIIEEPENLNNRHGSPDSYRKYDRSRGIVEEPRSRSQLHQDYPVIPKEIQEPKWNSPPFTDKIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQEHRNMPLNNALTFVARNFERYQKHVRDLKTIAPKPTFDPSRMPPGFIAPDDKIIYYLHLLADSRMLTIEELNEVIDFVQKRMQALASAEETMEKAPITGLPNESVQNSMAPKLSIPGNQPVREEKVIQHQTQLHSKILNILKPVPHQSASGVVDNEINNMEQFNTYNDSNISTSKSNNMVINPKVQQALDTLMQSQFRPTAPELSAPAEENSRNFQPVNNPMANPYSMNPTPNMRPINPHSTQQRPMAQGPGGQPFGNSFHGYYQPPIGQPIFRGRPPFQPRPQYPGY
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSPVGGEQQSRLQEINSKNYLRRVKDDVKSILDNFTSILSASKVKEESQLNGSAQSVMDRYEMHVRSSNITRAAESLVQLIDELKESLILDDFTSLNEANDAKRKQFEQYIQHSNSELQKIKHGIGQDLQQLETEYYNSAYK
The following text describes a protein:
Function:
Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.
Miscellaneous:
MISCELLANEOUS: Present with 8890 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to the active transcribed loci. Associates with the coding region of HTA1.
Sequence:
MEETGDSKLVPRDEEEIVNDNDETKAPSEEEEGEDVFDSSEEDEDIDEDEDEARKVQEGFIVNDDDENEDPGTSISKKRRKHKRREREEDDRLSEDDLDLLMENAGVERTKASSSSGKFKRLKRVGDEGNAAESESDNVAASRQDSTSKLEDFFSEDEEEEESGLRNGRNNEYGRDEEDHENRNRTADKGGILDELDDFIEDDEFSDEDDETRQRRIQEKKLLREQSIKQPTQITGLSSDKIDEMYDIFGDGHDYDWALEIENEELENGNDNNEAEEEEIDEETGAIKSTKKKISLQDIYDLEDLKKNLMTEGDMKIRKTDIPERYQELRAGITDYGNMSSEDQELERNWIAEKISVDKNFDANYDLTEFKEAIGNAIKFITKENLEVPFIYAYRRNYISSREKDGFLLTEDDLWDIVSLDIEFHSLVNKKDYVQRFYAELHIDDPIVTEYFKNQNTASIAELNSLQDIYDYLEFKYANEINEMFINHTGKTGKKHLKNSSYEKFKASPLYQAVSDIGISAEDVGENISSQHQIHPPVDHPSSKPVEVIESILNANSGDLQVFTSNTKLAIDTVQKYYSLELSKNTKIREKVRSDFSKYYLADVVLTAKGKKEIQKGSLYEDIKYAINRTPMHFRRDPDVFLKMVEAESLNLLSVKLHMSSQAQYIEHLFQIALETTNTSDIAIEWNNFRKLAFNQAMDKIFQDISQEVKDNLTKNCQKLVAKTVRHKFMTKLDQAPFIPNVRDPKIPKILSLTCGQGRFGADAIIAVYVNRKGDFIRDYKIVDNPFDKTNPEKFEDTLDNIIQSCQPNAIGINGPNPKTQKFYKRLQEVLHKKQIVDSRGHTIPIIYVEDEVAIRYQNSERAAQEFPNKPPLVKYCIALARYMHSPLLEYANLTSEEVRSLSIHPHQNLLSSEQLSWALETAFVDIVNLVSVEVNKATDNNYYASALKYISGFGKRKAIDFLQSLQRLNEPLLARQQLITHNILHKTIFMNSAGFLYISWNEKRQKYEDLEHDQLDSTRIHPEDYHLATKVAADALEYDPDTIAEKEEQGTMSEFIELLREDPDRRAKLESLNLESYAEELEKNTGLRKLNNLNTIVLELLDGFEELRNDFHPLQGDEIFQSLTGESEKTFFKGSIIPVRVERFWHNDIICTTNSEVECVVNAQRHAGAQLRRPANEIYEIGKTYPAKVIYIDYANITAEVSLLDHDVKQQYVPISYSKDPSIWDLKQELEDAEEERKLMMAEARAKRTHRVINHPYYFPFNGRQAEDYLRSKERGEFVIRQSSRGDDHLVITWKLDKDLFQHIDIQELEKENPLALGKVLIVDNQKYNDLDQIIVEYLQNKVRLLNEMTSSEKFKSGTKKDVVKFIEDYSRVNPNKSVYYFSLNHDNPGWFYLMFKINANSKLYTWNVKLTNTGYFLVNYNYPSVIQLCNGFKTLLKSNSSKNRMNNYR
The following text describes a protein:
Function:
Adapter protein which binds to its partners, usually via a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity and/or cellular localization of the binding partner (Probable). Via its interaction with CDPK1 and PKAr, involved in merozoite microneme secretion and thus in merozoite invasion of host erythrocytes.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Nucleus.
Sequence:
MATSEELKQLRCDCTYRSKLAEQAERYDEMADAMRTLVEQCVNNDKDELTVEERNLLSVAYKNAVGARRASWRIISSVEQKEMSKANVHNKNVAATYRKKVEEELNNICQDILNLLTKKLIPNTSESESKVFYYKMKGDYYRYISEFSCDEGKKEASNCAQEAYQKATDIAENELPSTHPIRLGLALNYSVFFYEILNQPHQACEMAKRAFDDAITEFDNVSEDSYKDSTLIMQLLRDNLTLWTSDLQGDQTEEKSKDEGLE
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Sequence:
MIGLKGILNVIDNTGALKVECINVLKVKTRLKSTGFATVGDEIVCVVNKARPIPANEVVKNPNASSNIQKIRKGDIRRAVVVRVKKTTQRPDGSVVRFDDSAAVLLNNKGEMLGTRIVGPVASELRKIKGGAGSGGRWEKIVMLAPKVV
The following text describes a protein:
Function:
May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.
Subcellular Localization:
Nucleus.
Sequence:
MGLDPTHGINVKGDMKQMLEELGTEKARQTALHGGGGNKAQNERAAALAAILAARSRIKEESESDKNGEGKTGQTFSIVDAASASVHGRSAAAAKATSSDKTAARIAMHMAGERAPVNAKMVKSRFTTGAASRSFTSTSYDPVTKNEFEYIKVEKNPTKKGYVQLHTTHGDLNIELHCDITPRACENFITLCERGYYNGIAFHRNIRNFMIQGGDPTGTGSGGESIWGKPFKDELNSKLLHSGRGVVSMANSGPHTNGSQFFILYKSANHLNFKHTVFGGVVGGLMTLSAMEKVPVDDNDRPLVSITIGFLHFRIISILKLKLLGILISSN
The following text describes a protein:
Function:
[Isoform 1]: Plays a role in sperm-oocyte fusion process during fertilization.
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=Localized to the equatorial segment of the sperm head; [Isoform 2]: Secreted.
Sequence:
MKLWLWVAVGVWMLMAELGTIETAPRRDGTRPSVSGARPQQVVNRLFFDYPDSDRASLLAVARFIGEKPITFVKTDSSPGLFQNILVGTLVVAFFFLLFQFCLHVNFQKGA
The following text describes a protein:
Function:
Required for replication of viruses with short cos ends (4 bases). Stimulates dsDNA end-joining by host LigD. Binds dsDNA with either blunt, 5'- or 3-overhangs, protecting it from host exonuclease degradation.
Sequence:
MRSVGNVDLTIGLVTVPVKMVGVSESHDRKASMYHPHEDGNFGKIKMPKLCEDCGEVVPTADIAKGFEEGGDIVILTADELASIAAATGAALEVPQFVKAEQINPMLFANENIYRLVPDPKRGRQAATTYLMVRHILVSQELVGVVQYTRWGRNRLGVLDVEPSDDGGVLVIRNMMWADELRSTEGIVPTNVTEDDIDPRLLPVMASVVESMTGDWDPTAYTDRYTEQLSEAITAKAQGDEIATVASESGKAIDDVSDLLAKLEASIQKKAPAKKATARRKKTA
The following text describes a protein:
Function:
Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation. Acts via its association with eef2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage. Plays a key role in ribosome hibernation in the mature egg by promoting ribosome stabilization. Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the egg and early embryo.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, Stress granule. Nucleus, nucleolus. Nucleus speckle. Nucleus, Cajal body. Note=Predominantly cytoplasmic.
Sequence:
MRLDTMKETPSSPVNTEMQDNFGCAVGNRFHQLLDDESDPLDFLYQSGVELTRRKKKEDAAAKKSANQKSGKKESQKDRKAAVVGGNTDVKMTPQTESGKVSQKDRKTFVVGGNTDVKVTQPGQKHAPKNMEKAPQNENVGSQVKVDRAERRPAFREVRPNIMDRSNEYSIEKPMEILDQDKQMRNYGGRGGMRGRGRGGFPRNTENDNLRGKREFDRHSGSDRAIRPEDKRGGSGPRNWGSIKEAFSEIEAIPVEEQIETTETTEATEEEHAKVPEEKNEGFSQEMSLDEWRSLQDQNRSKTEFNLRKPEAAVPTKAVVIHKSKFKNNLSENEEDYHYCFRKPVNDITAQLDINFGSLTRPSRGRGGGGRGRVRREEAFPHEVINVLADAPNPDDPEDFPALA
The following text describes a protein:
Function:
Dehydrogenates carotenes in the cis conformation: has cis-to-trans isomerase activity and mediates dehydrogenation of cis-phytoene, producing zeta-carotene via the intermediary of phytofluene by the symmetrical introduction of 2 double bonds at the C-11 and C-11' positions of phytoene.
Sequence:
MSASTQGRRIVVVGAGVGGLAAAARLAHQGFDVQVFEKTQGPGGRCNRLQVDGFTWDLGPTIVLMPEVFEETFRAVGRRIEDYLTLLRCDPNYRVHFRDRSDVTFTSELCAMGRELERVEPGSYARYLAFLAQGRVQYRTSLDHLVGRNYAGLRDYLSPRVLARIFQVRAHRRMYADVSRFFQDERLRAAMTFQTMYLGVSPYASPAVYGLLPFTELGVGIWFPKGGLYAIPQALERLAREEGVRFHYGAPVERILTDGGRTRGVRLEGGEVVEADAVLCNADLPYAYEKLLDPKATTLKRKEKLRYTSSGYMLYLGMKRRYPELLHHNVVFGRDYKGSFDDIFEFRVPEDPSFYVNAPTRTDASLAPEGKDALYVLVPVPHQHPDLDWKVEGPKVRAKFFARMAELGFPSLESDIEVERRSSTPDDWAGTFNLARGSGFGLSQNFTQIGPFRPSNQDARVKNLFFVGASTQPGTGLPTVLISARLVTERLMTWAHAQGVSLSPRTAAATPLEGVAA
The following text describes a protein:
Function:
FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
Subcellular Localization:
Bacterial flagellum basal body. Cell membrane; Peripheral membrane protein.
Sequence:
MPDDEILSQDEIDALLKGISGGEVETETAEAPSGVRPYDFTSQEKIVRGKMPSLDIINERLARSFRVSLASDIRKIVDVINVNVNITKFYDFLRSVPFPSSLNIIKLEPLRGFSLVVFDAPMIFTLIEFYFGGSGKGYYKPEGREFTPIEQRIIHKVVMMFLESMEEAWKPIFQIKPHFIRTEMNPQFVTIVTPVDVVIETEFTLEIETRECKIMVCIPYSSVEPIKEKLYSAFLADRDEMDMKWIGRLKAQIKNAPVQVEAILGKVTIDFKTLLDLKSGDIVTLQRRIDEEVDLLVEGVPKFKGKLGTFKGNYAIKIIKEA
The following text describes a protein:
Function:
May be necessary for the transcription, folding, export, or function of the cytotoxin.
Sequence:
MTNETIDQTRTPDQTQSQTAFDPQQFINNLQVAFIKVDNVVASFDPDQKPIVDKNDRDNRQAFDGISQLREEYSNKAIKNPTKKNQYFSDFIDKSNDLINKDNLIDVESSTKSFQKFGDQRYQIFTSWVSHQKDPSKINTRSIRNFMENIIQPPIPDDKEKAEFLKSAKQSFAGIIIGNQIRTDQKFMGVFDESLKERQEAEKNGGPTGGDWLDIFLSFIFNKKQSSDVKEAINQEPVPHVQPDIATTTTDIQGLPPEARDLLDERGNFSKFTLGDMEMLDVEGVADIDPNYKFNQLLIHNNALSSVLMGSHNGIEPEKVSLLYAGNGGFGDKHDWNATVGYKDQQGNNVATLINVHMKNGSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIRNKVDFMEFLAQNNTKLDNLSEKEKEKFQNEIEDFQKDSKAYLDALGNDRIAFVSKKDTKHSALITEFNNGDLSYTLKDYGKKADKALDREKNVTLQGSLKHDGVMFVDYSNFKYTNASKNPNKGVGATNGVSHLEAGFNKVAVFNLPDLNNLAITSFVRRNLENKLTAKGLSLQEANKLIKDFLSSNKELAGKALNFNKAVAEAKSTGNYDEVKKAQKDLEKSLRKREHLEKEVEKKLESKSGNKNKMEAKAQANSQKDEIFALINKEANRDARAIAYTQNLKGIKRELSDKLEKISKDLKDFSKSFDEFKNGKNKDFSKAEETLKALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSVKDVIINQKVTDKVDNLNQAVSVAKAMGDFSRVEQVLADLKNFSKEQLAQQAQKNEDFNTGKNSELYQSVKNSVNKTLVGNGLSGIEATALAKNFSDIKKELNEKFKNFNNNNNGLKNSTEPIYAKVNKKKTGQVASPEEPIYTQVAKKVNAKIDRLNQIASGLGGVGQAAGFPLKRHDKVDDLSKVGLSASPEPIYATIDDLGGPFPLKRHDKVDDLSKVGRSRNQELAQKIDNLNQAVSEAKAGFFGNLEQTIDKLKDSTKKNVMNLYVESAKKVPASLSAKLDNYAINSHTRINSNIQNGAINEKATGMLTQKNPEWLKLVNDKIVAHNVGSVSLSEYDKIGFNQKNMKDYSDSFKFSTKLNNAVKDIKSGFTHFLANAFSTGYYCLARENAEHGIKNVNTKGGFQKS
The following text describes a protein:
Function:
Probable methyltransferase.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSKPTDQLYYANGVDSYIAETHAWRTPETCSTYMLKYVKKTDRILDVGCGPGTITVGFPKYVPEGEVIGVEPSQELLDKAEEALRKEETLKKEKINNCSFRLGSIYKLPFPDNTFDIVNTHQVLVHLQDPVAALVELKRVTKPGGYVCCKEADLLSACVYPKEYEHDLLLQSQARINLHGTNPTAGRSLRGWAIDAKYVAENIHSSASTWCFADEETRKWVSRLFIQRVLHSNERLDDDDAKDQSLRKRVAEAWQRWKEDSRGCFFMTDGQIVYKKEE
The following text describes a protein:
Function:
Protein regulator of centriole-deuterosome disengagement and subsequently participates in the ciliogenesis in multiciliated cells (MCCs).
Subcellular Localization:
Cytoplasm. Note=Tightly associated to mature deuterosomes.
Sequence:
MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVLDSVNATYSDFKSNFAKRLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLTLGSRKEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASKGQKCLKQLFVTQNVVQQANGKMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWSFQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVSRSGGFFGHRGRVLHLSLSPDQTRVFSAAADGTASVWNCY
The following text describes a protein:
Function:
Baseplate protein that is part of the baseplate wedge and that connects the short tail fibers to the baseplate. Involved in the tail assembly.
Subcellular Localization:
Virion. Note=Present in 18 copies in the baseplate.
Sequence:
MSLLNNKAGVISRLADFLGFRPKTGDIDVMNRQSVGSVTISQLAKGFYEPNIESAINDVHNFSIKDVGTIITNKTGVSPEGVSQTDYWAFSGTVTDDSLPPGSPITVLVFGLPVSATTGMTAIEFVAKVRVALQEAIASFTAINSYKDHPTDGSKLEVTYLDNQKHVLSTYSTYGITISQEIISESKPGYGTWNLLGAQTVTLDNQQTPTVFYHFERTA
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MALGSVYNVLFKRTSTFALTCLVGAFVFERFFDQMSDSIFERINQGKLFKHIKKADAEGK
The following text describes a protein:
Function:
Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides. In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety. However, the triacylglycerol hydrolase activity is controversial and may be very low. Possesses phospholipase A2 activity.
Subcellular Localization:
Lipid droplet. Membrane; Single-pass membrane protein.
Sequence:
MYDSERGWSLSFVGCGFLGFYHVGVTRCLCERAPHLIRHAHRFFGTSAGALHCAVFLSGTSLDQTLEMLMGLVRSARSRSLSILHPSFNLSKRLREGLRRILPDNAHQLLSGKLCISLTRVSDGKNVLVSDFRSKEEVLDALLCSSFIPLVSGFIPPSFRGERYVDGGVSDNVPFFDSKTTITVSPFYGENDICPKVKSTNFLHVDFTKLNLRLCSENIYLISRALFPPDVKVLGEICLRGYLDAVRFLEENGICDRPYPGLNVSLAEWDVFEPPWEPLSPDSSPGVAAWEARPEGDELLDHLRLSILPWDEHIRILSPKLMLALREAARNPDGYISKMCNFLPIKVVSYMLLPCTLPLESAIAVVQRLVMWLPDMPDDIQWLQWATSRICCRVMRCLLPTSRSQTPANGHQPPPTNQNTRGAASLPIPPWTRTPTPWTGQ
The following text describes a protein:
Function:
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
Subcellular Localization:
Nucleus.
Sequence:
MEEVIKNTHAYVDVLVMARGDAVITWEKETFERAFKWARYFEGVYTKLKSKPALAEKLNKYLNNFNKTESVFLGNLKLTFKSLQISGKILKQFLLQNPHISSEQFPLVIMLYSVIIGGANEQDTTDLTEDLVRICQLKGCMSVLSDMRCKLSDDLLVMTKRNDEQSNGHLSDNEYRYNTARELKWADIGCLTVDDVGIMSLAEMLFNYVYHNLTCSGKDVKSLQKKLLHFASQANGLQVIASCLAFIPAGIQQLSQAGPVHKFLLNFLEGYLCNNSVAANFWQLPLRILSCVSFKYDSILNMYLNHLLGWGQHMIPVISLQQCGNTRTKSCQVYQWRYKTSNEMTQGGLDNLERAKTFEALVEHFRALTDGPDYVKRRCRNAIQDVQREALLSCGSNKLGASIWADLEKALL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLASSKRMNSSSRSQILLRWKSDKAQSGPYNVEKEILTSRFLRDTETCRQNFRNFPYPDLAGPRKALSQLRELCLKWLRPEIHSKEQILELLVLEQFLTILPGEVRTWVKSQYPESSEEAVTLVEDLTQILEEEAPQNSTLSQDTPEEEPRGKHAFQTGWLNDLVTKESMTFKDVAVDITQEDWELMRPVQKELYKTVTLQNYWNMVSLGLTVYRPTVIPILEEPWMVIKEILEGPSPEWETKAQACTPVEDMSKLTKEETHTIKLEDSYDYDDRLERRGTGGFWKIHTNERGFSLKSVLSQEYDPTEECLSKYDIYRNNFEKHSNLIVQFDTQLDNKTSVYNEGRATFNHVSYGIVHRKILPGEKPYKCNVCGKKFRKYPSLLKHQSTHAKEKSYECEECGKEFRHISSLIAHQRMHTGEKPYECHQCGKAFSQRAHLTIHQRIHTGEKPYKCDDCGKDFSQRAHLTIHQRTHTGEKPYKCLECGKTFSHSSSLINHQRVHTGEKPYICNECGKTFSQSTHLLQHQKIHTGKKPYKCNECWKVFSQSTYLIRHQRIHSGEKCYKCNECGKAFAHSSTLIQHQTTHTGEKSYICNICGKAFSQSANLTQHHRTHTGEKPYKCSVCGKAFSQSVHLTQHQRIHNGEKPFKCNICGKAYRQGANLTQHQRIHTGEKPYKCNECGKAFIYSSSLNQHQRTHTGERPYKCNECDKDFSQRTCLIQHQRIHTGEKPYACRICGKTFTQSTNLIQHQRVHTGAKHRN
The following text describes a protein:
Function:
Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg-laying. May play a role in neurotransmission.
Miscellaneous:
MISCELLANEOUS: Lacks conserved metal-binding sites and has only weak affinity for copper in vitro.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Early endosome.
Domain:
The NPXY motif mediates the interaction with clathrin.
Sequence:
MTVGKLMIGLLIPILVATVYAEGSPAGSKRHEKFIPMVAFSCGYRNQYMTEEGSWKTDDERYATCFSGKLDILKYCRKAYPSMNITNIVEYSHEVSISDWCREEGSPCKWTHSVRPYHCIDGEFHSEALQVPHDCQFSHVNSRDQCNDYQHWKDEAGKQCKTKKSKGNKDMIVRSFAVLEPCALDMFTGVEFVCCPNDQTNKTDVQKTKEDEDDDDDEDDAYEDDYSEESDEKDEEEPSSQDPYFKIANWTNEHDDFKKAEMRMDEKHRKKVDKVMKEWGDLETRYNEQKAKDPKGAEKFKSQMNARFQKTVSSLEEEHKRMRKEIEAVHEERVQAMLNEKKRDATHDYRQALATHVNKPNKHSVLQSLKAYIRAEEKDRMHTLNRYRHLLKADSKEAAAYKPTVIHRLRYIDLRINGTLAMLRDFPDLEKYVRPIAVTYWKDYRDEVSPDISVEDSELTPIIHDDEFSKNAKLDVKAPTTTAKPVKETDNAKVLPTEASDSEEEADEYYEDEDDEQVKKTPDMKKKVKVVDIKPKEIKVTIEEEKKAPKLVETSVQTDDEDDDEDSSSSTSSESDEDEDKNIKELRVDIEPIIDEPASFYRHDKLIQSPEVERSASSVFQPYVLASAMFITAICIIAFAITNARRRRAMRGFIEVDVYTPEERHVAGMQVNGYENPTYSFFDSKA
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Binds to the flavoprotein subunit SdhA in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SdhB into the SDH catalytic dimer (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MQSVTRQTARVLPQMGKQVSYLSTSGAWRATASGGDMVVEIKEPKTRTEKLMAFQKKLRAKTPLGKLDEFSRHPYQEKEPLKPWPNQTNPYTGEIGGPAGPEPTRYGDWERKGRVSDF
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSARVAFSFFIFILFAPIESNKTDRRIEELKQLSARNGAILLDYFTFKNYVTKSKNYTVIMLLVAVRPERRCFTCGKVLEDFLVLTNSWKMSPDFNTDLFFAYADYDSKGERIFEYLKANSVPDMLVYSKERLTPIKVSLRSDTNPERLAKLLRSYVPYHIRIYRPWNYLNVAIMVAFSLIISKLLIKYRSTLYDFVSFASPSMCACFVMLMLSGHMWNHMNARSFVHGEGSDMKFIHPGRREQVVAETPIVFLIC
The following text describes a protein:
Function:
A transcription factor that is probably redox-responsive. Probably plays a role in immunomodulation and reactivation after chronic infection. Its induction results in transcription of a number of genes including sigM, and the genes for 2 type VII secretion systems ESX-2 and ESX-4. Seems to negatively regulate its own expression. The apo-form has been shown to act as a protein disulfide reductase. The apo- but not holo-form probably binds DNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MAHPCATDPELWFGYPDDDGSDGAAKARAYERSATQARIQCLRRCPLLQQRRCAQHAVEHRVEYGVWAGIKLPGGQYRKREQLAAAHDVLRRIAGGEINSRQLPDNAALLARNEGLEVTPVPGVVVHLPIAQVGPQPAA
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MDPNCSCATGGSCTCAGSCKCKECKCISCKKSCCSCCPVGCAKCAHGCICKGTSEKCSCCA
The following text describes a protein:
Function:
Plays a critical role in cytoplasmic virus egress. Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid. Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating (By similarity). Additionally, antagonizes the viral DNA-triggered antiviral immune response by targeting host STING1 and preventing its dimerization and trafficking.
Subcellular Localization:
Virion tegument. Host cytoplasm. Host nucleus. Note=Localizes in the host nucleus up to 18 hours postinfection, but at later times localizes to punctate, cytoplasmic structures.
Sequence:
MAWRSGLCETDSRTLKQFLQEECMWKLVGKSRKHREYRAVACRSTIFSPEDDGSCILCQLLLFYRDGEWILCLCCNGRYQGHYGVGHVHRRRRRICHLPTLYQLSFGGPLGPASIDFLPSFSQVTSSMTCDGITPDVIYEVCMLVPQDEAKRILVKGHGAMDLTCQKAVTLGGAGAWLLPRPEGYTLFFYILCYDLFTSCGNRCDIPSMTRLMAAATACGQAGCSFCTDHEGHVDPTGNYVGCTPDMGRCLCYVPCGPMTQSLIHNEEPATFFCESDDAKYLCAVGSKTAAQVTLGDGLDYHIGVKDSEGRWLPVKTDVWDLVKVEEPVSRMIVCSCPVLKNLVH