lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH.
Sequence:
MPYPFVLPTTSSFSFTSCFSCESHPSLPLNASTRRGVVREDLKAFKRTPREHQVAKLPTVVSSLIAYLPYLFAVDAGLSQQAINGEEIAVILKTAPIIEWRPTLSDNAAVAVPGKDPARVKVHSLEYEVFFVLSCLANAHTLQARTALHPLYVLSTAPVGTQQRQVAVSAATKNLLDAASIYDYLALRAEGLSSGYGMAPPCADISPAALRAQCSLAMAEATLLAVLKDDPYPAVVAQDRNKNDTEWMYKAPDIPKVRAHLFARLCLAASEHAAQAYSLCAGLARAEGGAKVTESFLKYLDNLRRTSRAKACRFFGIDSELGGQTGTAIAWLNAGLQELGVERNPSEGGSKRSGGLGRLKEKWTEKREDKKVERGLDWGADAGRLEESRVYEMLWEKWSKQNDTIMTQVVPPSGPLLQQMPMGREIHTLKPFQPPQLDPPTLEAMRAPPERSDDAALYPSSDEDDTMIGATIGAFPGTQGHFRTGTPNYF
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which seems to be clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. It also function in maintaining the identity of lytic vacuoles and in regulating the transition between storage and lytic vacuoles.
Subcellular Localization:
Endomembrane system. Golgi apparatus.
Sequence:
MAATSSAPSLVDTLFQRSLDDLIRSLRSSSSSSVLEAAAITRALDEIRREIRSPDLDTKAVALQKLTYLASLHHLDMSWAAFHALELLPSPSLPHPRVAYLAASLSFHPSSTDLLPLATHQLRKHLAPSPANTPALVAPALHVLALASSADLACHLAPDLLPILSGQSSNPLRPKAIATALRALAVCPDAAPVLFKPLVDCLSLSSEPSAVSAAVSAFCELALAAPDPSPYLPLAPEFYRLLVDSRNNWVLIKVLKIFARLAPLERRLAVRILDPVCQLLRRSPAKSVVFECIRTVLSSLSDHDSAVRLAVDKIKEFLASDDDPNLRYLGLQALAMLGPAYLWAVDESREVVIRSLNDTDTNIRHQALCLIMGMLRESNVVEICNLLIKYAMKSDPDFANEILDAVLATCGRNVYELIVDFDWYVSLLGEMARNPHCAKGDEIERQLVDIGLRVRDARPELVRVARDLLIDPALLGNPFLCRVLSAAAWVSGEYVESSRNLLELVEALLQPRTNLLSLLVRAVYIQAVFKVVTFSFIFFIKQIQAFDTKSSADRNAAFENENDVATADKAVIFDSIDNNETFKHESLSHLLDFVETTVGPLSECDNVEIQERARNVLGLIHIIRETQYWDIVAEHELTRDKKISEIVELMEAAFSEELGPVSTNAQKRVTVPEDLILNENLSDLAEVLGDIDVTPCTSISFSLRCHHPTETKEDSAPVIEASSLLAEHRKRHGLYYLPTEKDEVESNDYPLANEPLLAVSHVDDAKDIVKLTAQSFIPRKEKPMKPRPVVIRLDEGDGDSSSGLTMVKEFKDDLLSGAIRNVLLGNESKPSSSCDMSSDRTSRRGETDASNNNELFSQPKESNALDGREHRKSSSRKSRHHTRHKEKNGSLGNEDIEETSHRHSTRSSRHQGRHKHRERGDAPPDVVSQEPVIQDFLL
The following text describes a protein:
Function:
HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.
Subcellular Localization:
Cytoplasm.
Sequence:
MPVDVSQWNGALALNEVEEKPAQPLLVTYGSLGIDELGQVLTPTQVQSRPSSIEWEGMDSSKLYTLVLTDPDAPSRKNPKFREWHHFLVVNMKGNNINSGCVLSDYVGSGPPKGTGLHRYVWLVYEQTEELKCTERVLCNRSGEHRGMFKVASFRQKYKLGTPVAGNCYQAEWDDYVPKLYEQLSS
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Subcellular Localization:
Nucleus.
Sequence:
MALDAKEIELKAKALTKAATQNEPPANIVSLLKELQQGVKASEDLLRSTRVGIIVNKFKQHKAPEVARLSSEIVSKWRNEVNKQKASGSASASQRSSASPRPPQNGTASPASATPSDKMSKLAVPPDKRTWKADGIDINQTGNRARDNCIGLMYDGLCLHSAEPPKAVLSKAAAVEAAAYDAYGPETKEPYRTKIRSLFQNLKNKSNPTLRVRVLSNEVTPERFVKMTHEELRSDEQREKDRKIQKENMDKAMVAQAERSISTSLQCGKCGQRKVTYTEAQTRSADEPMTLFCTCMHCGKSWRQ
The following text describes a protein:
Function:
Acts as an essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules.
Miscellaneous:
MISCELLANEOUS: Present with 2610 molecules/cell in log phase SD medium.
Subcellular Localization:
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Note=Associated with the kinetochore.
Sequence:
MSAPTMRSTSILTEHLGYPPISLVDDIINAVNEIMYKCTAAMEKYLLSKSKIGEEDYGEEIKSGVAKLESLLENSVDKNFDKLELYVLRNVLRIPEEYLDANVFRLENQKDLVIVDENELKKSEEKLREKVNDVELAFKKNEMLLKRVTKVKRLLFTIRGFKQKLNELLKCKDDVQLQKILESLKPIDDTMTLLTDSLRKLYVDSESTSSTEEVEALLQRLKTNGKQNNKDFRTRYIDIRTNNVLRKLGLLGDKEDEKQSAKPDARTQAGDIVSIDIEEPQLDLLDDVL
The following text describes a protein:
Function:
Serine protease inhibitor that inhibits chymotrypsin (Ki=3520 nM).
Subcellular Localization:
Secreted.
Sequence:
MSSGRLLLLLGLLTLWAELTPVSGLGRPKFCELPPEPGLCNARKTFFYYSLHSHACQKFIYGGCGGNANKFKTIDECHRTCVG
The following text describes a protein:
Function:
Required for proper contractility of visceral smooth muscle cells. Mediates nucleation of actin filaments.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere.
Sequence:
MSRRKVKGLTKTGRQVSEDPELDSLLSNLSTAEMEELEKEVSVVPDPDPSEIIVVDQTDLKPSAPVRKESQLSSQTDDFKSRFQRNLSTEVEPKKESRKQEYLRKMGLSQEKNISASDSRDGGLQRTSSTSSFPKRDSRLEDRTRRVTEGTRDEKFGPSAVSKRDEEIEKKNETKDQNDGSRLRDRREMRESSSSKTKELISKLQEKKEDSKEKNKKEDRGKRESGESRAKEMISRIQEKEEKEREKKEEIRKREETKSKGYISRLEENQNQVHEDKTKEENKHRDEKQIRSSEKVKETTALSENKEKESENVKRLQECNAKSSDKGRGDVQKHNENVNEVHKPKEEKIENCVSDTILKGKTKEEEEDDESASMFDEDLEKVRRNDPGMTDLNVNNSEVIKTKTLIQFSEALKNNTHIKAFSLANCRADDHVAYAIADTLRNNKSITSINLDSNLLTSKGIMSLIQALQHNSTLTELRFHNQRHIIGGKSEMEMTKILKENTTLLKLGYHFELAGPRMTMTNILSRNMDRQRQKRLQEQKQAQAQGAGDKKDSLGVPKPSFGKGSPRASPIPSPIPSPAPSPKLTHKKRVSGLVGGPPPPPPPPGGPPPPPPPMLDGDFLKNSLTPVSQRKLDDRSGGRGAAQNTRDQLLASIRNSNVKQLKKVAVPKLLQ
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Miscellaneous:
MISCELLANEOUS: Only 10% of the activity present in the wild-type strain is phosphofructokinase-2; MISCELLANEOUS: This enzyme is not to be confused with 6-phosphofructo-2-kinase which is also called phosphofructokinase 2; MISCELLANEOUS: E.coli has two 6-phosphofructokinases enzymes.
Sequence:
MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGGGINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPVATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQGIRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPPVKSQSTVGAGDSMVGAMTLKLAENASLEEMVRFGVAAGSAATLNQGTRLCSHDDTQKIYAYLSR
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
MEKLCPLENDCFIFPYKDNKYIKKHLKKCPLYIKNLYLHYTPFYFPYINDSNTYILKHKDVENMLNEYYILFNNIILDTIKKKMSIPIKTFDNFLYMKYNLLLIWYIKYGKDVFFSMLENDIYKEKLHNKLNNNINKSNIVDINIEEQNLLFYIHINKLKDIICNKRNIYNNNKERNPKYCVNEFVIQKNEISTPHIYNNNNICLEKDYNNYNTSTKEQHFCDSKKINDHDENCSSPNKKGGCNKMDERQNDEYKKSINMYKQHDESNKYTLPILTLKNIGNIHNYKITRDIINYVDVFIFRYPDFFDDEERKRKGAKRKKNDNNKKNDGNNNPNDGNNNPNDGNNNPNDGNNNPNDGNNNPNDGNNNQNDGNNNQNDDDYKNIFDETKNKTSFKLVEKNELDKDEILSIIIYLTIYLCCKLNIMKRIKNKNFNRKDMEKIKEKDIYSIFFFLNNLDKHDIQNINLLFLLVYFNNSFYVHFHNLLNQKEIFISSTHTNIQSLFIELGAGKANTTRWINFIMNNLGDILQKYNVNKGEPKNDDKKMSYINNDNNKKNDQHNILCTNEPSALLHPSQAAYEKCKMLIIEKESLRNKKEMKDFFMQIEHNNNENILRIRTNVSDFNLNKFIHFIKDKNVQENHFLVPDIIQFYYYNDIYKKIEKEKGKENKELNTKDEQSKYITHIKKFNSDKTSFISEEFLKNNLLCIESYLDINMKKLFTALTQGNNNLKKVYNNVNNFLKDLDFQKVTYLTKHLCGNGSDLALRMLVNSVKDNVVENYFILAPCCHHRCEVKKIVGYKYLKELNIDKNLFQHMVNHMSGYASCNVPEKKSIGKKIKLVIDLSRILYLLEEGLQNSYLIKYVNRHITLENYAIVFFNHQNLNLTNFKYF
The following text describes a protein:
Function:
Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Early endosome membrane.
Sequence:
MASVRVAVRVRPMNRREKDLDAKFIIQMQGNKTSITNIKIPEGISGDSARERIKTFTYDFSYDSADNKHANYASQEKVFKDLGSDVLKAAFEGYNACIFAYGQTGSGKSYTMMGNPGDQGLIPRICEGLFSRIAGMTRWDEASFRTEVSYLEIYNERVRDLLRRKSTKTYNLRVREHPKDGPYVEDLSKHLVQNYSDVEELMEAGNINRTTASTGMNDVSSRSHAIFTINFTQAKFDAEMPCETVSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQEAVSSHVKKKQVFVPYRDSVLTWLLKDSLGGNSKTIMIATVSPADVNYGETLSTLRYANRAKNIINKPTINEDSNVKLIRELRAEIARLKALLAQGNQIALLDSPTALSMEEKLHQNEARVIELTKEWTNKWNETQNILKEETLALRKEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGRTYVGRDDAATEQDIVLHGLDLESEHCVFENLNGTVTLIPLNGAQCSVNGVQIMEPIQLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSCENLSAVMLYNPGLFTVKGPICLRLEFERQQREELEKLENKRKLIKEMEEKQKCEKAELERMQQEVESQRKESEQVQLRIRKQEESLKRRSQDIESRLKDLLAEKERFEEERLREQQEMELQKKKQEEEIHIRVQKEQERLQEIHQKEKAEKMEIFRELEKLKRERDEQSIKMELEKRRLEKQEQEQLSLVFRLEEQLREKQEMIRLLKRDDVQRVEEEKRILEEIRGVLLKAKEARPDGDEEHDDVKNAKQRYMSFKMKQLEQLQLLEQRLLQQKDHLEKDISSERKALGHLLRVHEEHQKVLRETQEKGTLDATNVAQEKERIKQAEQRLQYKERQLHCLTENHLPTITEEKQRSAEIVEKGLPGLDNTLYQIEKEIEEKAEQLALYCASADQLQQLQETYEFTANVARQEEKVRRKEKEILESKEKQQREALEQAVAKLERRHSALQRQSTIELEIEEQKRKLASLHHSEEQVGLQASLEAEHKALEQDRERLEREIQQLKQKICENDGALRSLYTGSDEKSSHSSSPVSPKQSLPTLIPVVDDRINAYIEEEVQRRLQKLNQTNGDNNIELSLSTETLKEEEQSSNDGSSLKLTDEEDEKSHNGVDPRKQKYEQWLISRPLGPSPYSLKDPVKISIPRYVMRGQGKDEHYEFEVKITALEETWTVFRRYSRFREMHKTLKLKYPELAALEFPPKKLFGNKDERVIAERRTHLELYLRNFFKVMLDSPTSPLHADKTGLQLSKHTICEFSPFFKKGVFDYSSHGTG
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Deubiquitinates H2BK143ub1 of histone H2B.
Subcellular Localization:
Nucleus.
Sequence:
MSRPTTRSKNKRHKPDNNEGFSSEILRKIHLTGEITEDDIHQLYMIWKPVCQGCRINTKDNPNCFCGLVPPSGGTRKSGLWQKMSDIVLSLGPDPCKDLRVSNESPAGLTNLGATCYANSILQCLYMNTAFRRGVFSIELDLLKKQPVLHQLARLFAQLHSSKMAVIDSAPFIKTLELDNGVQQDSHEFLTLLLSLLERSLRHSKISKARTIVQDLFRGSVSNVTRCSMCGRDSEASSKMEDFYELELNIKDMKNLNESLDDYLSVEELKGDNQYFCESCGERVNATRCIKLRTLPYVLNFQLKRYVFLPKTTTKKKITSLFSFPRELDMGRRLSEPSLLELIYDLSAVLIHKGNAVNSGHYVAHIKDEHTGQWWEFDDEHVSMLGDHPFGEGSSSSTAKPVWNEPLVQSSCTGEKDSTVNGNLINTGDVQMFSSADAYMLMYKRRTIQKVDNMQLTGCGSSNMETPEKLVYESNNYCPPFHLLEEIKELNESYDDTCQQYKLKKEKEVENITERRQEVRSVLSEVPVHPLEESYFWISTDWLRQWADSITPPVLDNTSIQCLHGGVPVSKVGAMKRLSTNAWNKLLLKYNGGPALSNKDNCINCLLDGAHSMVSADNYRDRRASMKELAEAALAGRSFDGPLYYVSRAWLLQWLRRKNVDSPCEADAGPTASIRCPHGLLMPEQAAGAKRLLVPESLWLFFYESANAVKPDDLLGCSTFPVDSEVCARCSAELSQVACLEDSLRAAKLKQRQNHEKLVLGKNIALSPGCRYYLLPSSWLTKWRTYITASGKNVSASVEPESLDNILDSLKCEKHSHLLERPLSLTYKRGIVVQRVSNTDGLTIITEDDWKFFCEEWNCTEEKGISAKIEFPNCVSNKLPGSCKDVPVLDEHLSISLDEANDEAESSLPIIKTIPEICENCIGERESCELMRKLSYCNENICVYLVRGKEAPRSILEASATFVDSDRRTSKRSRKTPFGNSVNLKVSGSTSIYQLKMMIWESLGVVKENQILHKGSRVIDGESATLADMNIFSGDVLWVTDSEVHENRDIADELSEGKMVVEQTEAGFRGTLLTSNITTQLLIQEK
The following text describes a protein:
Function:
Probable transcriptional regulator involved in developmental processes (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence (By similarity). Is required for normal development of the pharyngeal arch arteries (By similarity). Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily.
Subcellular Localization:
Nucleus.
Sequence:
MISAISSPWLTQLSHFCDVAAFTTSSLSSLNTPGSYHLSPSPGDPYSHHESQFEPCPAAQHAYNYSGSNSAQAPAQGDSGTSNCSSSSSSSTPNKTLVKKNPKVANINVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKIFGMDPMADYMLLMDFLPVDDKRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDSEKYAEENYKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPGSLQIMSAFARTRNPMSSPPQQNGTEKEDSRREYDRDPSGNPLHSDPTHQLMSRVLSPALPVLGGLHAVPLTAGPRSPPHELRLDGHPQPPDTLHHHPYKYPATYEHYLGAKTRPSPYPSPSIRGHGYHPHMNPTTANMYSATSAPTNYDYGPR
The following text describes a protein:
Function:
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MSSPSYAGLPTSALSVKMICSECREDPPNLVEEFSSGDTVCGSCGLVLGDRIVDTRSEWRTFSNSDEANGDPSRVGKVANPLLNGSQLDTSISSTDGTGAMLAKAQGRSVQVRGEKNLLTAYKEISAMCDAISLPKVIADTAKQLFKRVDDHKALKGKSSQSIIAACIYIACRQGKVPRTFMEICTLTNVAKKEIGRVYKTLQRMLTEGGALHNSVDAFKGQEYIQNSSTSAEDLMVRFCNRLQLPTFVQLAAAELARRAGQEGTLAGRSPISIAASGIYMISSLMGYPKTPKEISEVTGVSDSTIRIAYKLLHAERNKLVDPKWVAKDRTMDSLLPKP
The following text describes a protein:
Function:
Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSSRAVSLFSKCGSRISQTRGKAHFTFQPSTTLPAGLENLEKTKMNLMQSVNEAMRIAMETDDSAVLFGEDVAFGGVFRCSLDLQKKFGKDRVFNTPLCEQGIAGFGIGVAAAGATAIAEIQFGDYIFPAYDQLVNEAAKFRYRSGNQFDCGKLTVRTTWGAVGHGALYHSQSPEANFTHTPGLKLVVPRGPVQAKGLLLSCIRDPNPCIFFEPKILYRLASEDVPTGDYTIPLGQAETVRSGKDLTLVAWGTQVHVALEAAQLAKEKLNADVEVIDLQTIQPWDEDHVVESVQKTGRLIVTHEAPISSGFGAEIASTVQKRCFLNLESPIDRVAGFDTPFPHVHEPFYLPTVHRVFDAIKKSVNY
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MSSKPINNSNNNNNNNNNSIQSANPHIIEFLQQQIDFIKSRPGADLKKTSIYKKAIHSLTLYPLPIFNGKECEALSGFGPTLSKKVDQFLKTKSHPLYPKGPPTPLKIIYSRTSNIEIDNNDENKSPKKRQRKTKTKDDKENIDKPKPSRSRAKSTKTTSTSKPNNFIEIVDDDILQLTNDINPTINESFNESFNFDFGSFDLNNVNNNNFIDSSNSTSNNSNNNNKPNNTPLKFNKHQITPIKSPYNSNKFNDSIIFSPISPVKFTTPLKNKKRKHELTSPSTAKSPSKYNHMMSLAFSPKRILRSTPVKSKPDKESVSIQSTPIQSKNSYIFSEDENDINTINIINNNINNNKKQLIKPIRLSFTEEDLLKVNIGSDIDNKSTSNSTTITTTTTTTTTTTNNSSKKIINFKEIKCFIDNREVKSVTERDYIVNKLKNNGINAEIKKLELGDFIWVAIDEKGEEWLLDYIMERKRIDDLSSSIMDGRYKEQKFRLKKTGCNNIIYLVEGVLSNNIMASQQYKKWGSVNFGLSPDALASALVSTQINDDITIKQTISLEETIEYITFTTEYFKDKLCKPSFLSTSNPSHLETLKKFIYKGEIIQCSVDTFNQSNVKSKGLMLLEFFAIQLMQIPGISPEKARTIVDHYPTPYSLYIALKRFKGDDKTASNFFKDFEFGKNNRKFGSDISERLFKIYNNKTYS
The following text describes a protein:
Function:
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling (By similarity). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (By similarity). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (By similarity).
Subcellular Localization:
Cytoplasm. Cell membrane. Postsynapse. Presynapse.
Domain:
The PH domain binds anionic phospholipids and helps recruiting ADRBK1 from the cytoplasm to plasma membrane close to activated receptors. It mediates binding to G protein beta and gamma subunits, competing with G-alpha subunits and other G-betagamma effectors.
Sequence:
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFYLNHLEEAKPLVEFYEEIEKYEKLETEEERVVRSREIFDSYIMKELLACSHPFSKNATEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFHKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEIKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEDEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRSHRLPPLQGVWEASAAGQPGLSGWLYHHSIIAFARILHHNFLPERHKIGFPALEGGRSDGNIDLEQASCSPSGSTTTSSCWEVASVASSSYETHPLRISAAAPAVSLGAEDACQAIVVHQKPSIRGTQVSGQRFPNSSSPILNPLWTQFQRFYAFRPRTNQRPYAREDGPPRPPPLRRSQQVQTSKLEVPTEKQYVPSVRDLKRVFVPKEIVVPDGVTVRQLAGLLSEKQDVILSTLSALGDGDLKPFDSVPLDSAELVALELGKVIKRGKRAWEDARGSAKKGAAASSWPKRPPIITVMGHVDHGKTSLLDALRSTSVAAGEAGGITQHLGAFVVRMPGGAELTFLDTPGHAAFSAMRSRGAAVTDIVILVVAADDGVMPQTREALAHAREAKVAIVVAINKCDKPGADPARVRRQLLEEGLELEEVGGDVQVVEVSATARQGLQSLEEALLLQADLMDLRADVTREAEAVVLEARQDKGQGPLASVLVKCGQLAPGTHLVVGQLWGKVRALRDPSGRLVTSAGPAQPVEVLGLKGLPETGDEVLAVATEERARRIAEGRAAQAEARRRESTVMDMREKLLEQARLRSATAAAVGRTTRVFSEVNMPTLQSLLDAAAGEGAGAGAGERWELAVVVKADMQGTAQAVTDALLALSGPQIGLSVVHAGVGPVSLSDVETAAACLKSRRCTRAAVVGFNVKAGAPVEALAAAKGVPLHQHRVIYHLLEDVGTAMVNLAPGTKESRAAGQAEVLQIFGVKKKGVPEKTAIAGCRVTDGSLRRGASVRILRSGRCVYEGRLDSLKREKNDVERVDKGKECGLTLDFRDWVVGDTVECLEDVMRRPKLVSDKSGKLTLQA
The following text describes a protein:
Function:
Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM).
Sequence:
MSVIAGVFGALPPYRYSQRELTDSFVSIPDFEGYEDIVRQLHASAKVNSRHLVLPLEKYPKLTDFGEANKIFIEKAVDLGVQALAGALDESGLRPEDLDVLITATVTGLAVPSLDARIAGRLGLRADVRRVPLFGLGCVAGAAGVARLHDYLRGAPDGVAALVSVELCSLTYPGYKPTLPGLVGSALFADGAAAVVAAGVKRAQDIGADGPDILDSRSHLYPDSLRTMGYDVGSAGFELVLSRDLAAVVEQYLGNDVTTFLASHGLSTTDVGAWVTHPGGPKIINAITETLDLSPQALELTWRSLGEIGNLSSASVLHVLRDTIAKPPPSGSPGLMIAMGPGFCSELVLLRWH
The following text describes a protein:
Function:
Has alpha-glucosidase activity.
Sequence:
MEAAVKEEISLEDEAVDKNIFRDCNKIAFYRRQKQWLSKKSTYQALLDSVTTDEDSTRFQIINEASKVPLLAEIYGIEGNIFRLKINEETPLKPRFEVPDVLTSKPSTVRLISCSGDTGSLILADGKGDLKCHITANPFKVDLVSEEEVVISINSLGQLYFEHLQILHKQRAAKENEEETSVDTSQENQEDLGLWEEKFGKFVDIKANGPSSIGLDFSLHGFEHLYGIPQHAESHQLKNTGDGDAYRLYNLDVYGYQIYDKMGIYGSVPYLLAHKLGRTIGIFWLNASETLVEINTEPAVEYTLTQMGPVAAKQKVRSRTHVHWMSESGIIDVFLLTGPTPSDVFKQYSHLTGTQAMPPLFSLGYHQCRWNYEDEQDVKAVDAGFDEHDIPYDAMWLDIEHTEGKRYFTWDKNRFPNPKRMQELLRSKKRKLVVISDPHIKIDPDYSVYVKAKDQGFFVKNQEGEDFEGVCWPGLSSYLDFTNPKVREWYSSLFAFPVYQGSTDILFLWNDMNEPSVFRGPEQTMQKNAIHHGNWEHRELHNIYGFYHQMATAEGLIKRSKGKERPFVLTRSFFAGSQKYGAVWTGDNTAEWSNLKISIPMLLTLSITGISFCGADIGGFIGNPETELLVRWYQAGAYQPFFRGHATMNTKRREPWLFGEEHTRLIREAIRERYGLLPYWYSLFYHAHVASQPVMRPLWVEFPDELKTFDMEDEYMLGSALLVHPVTEPKATTVDVFLPGSNEVWYDYKTFAHWEGGCTVKIPVALDTIPVFQRGGSVIPIKTTVGKSTGWMTESSYGLRVALSTKGSSVGELYLDDGHSFQYLHQKQFLHRKFSFCSSVLINSFADQRGHYPSKCVVEKILVLGFRKEPSSVTTHSSDGKDQPVAFTYCAKTSILSLEKLSLNIATDWEVRII
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MLLRSFHYILLNWILLFLFTVCKAKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTLRIFINSLTPNYLDHKVDRYKYVSNPLNSFGLLRRAHQDWPKLIAYLKDQGNIKVDIEEMNKLINRTPHANDMEEALMGMDRIEHFYDLKSSDMAQGLVAGQQLSSRMSASDCLALADYMYKRSEFRRAAEWYRIALSVFTKPKNNIAFKFYAPKRKELEKMFVISRLQEGSVENLTDCLKELSQDPNNSLVHLRPRKSPTMIEQGCQGKFPPGPQLVCRYNSTTTPFMRIAPLKEEEISRDPLIWLYHDVIYDSEIAQLTNVTREEMILGTTTNYTTPDRVNRLFHIKVTDDDGGKLDKTLVNRMADISGLDVGNTTTLARINYGLGGYFQEHSDYMDIKLYPELTEEGDRLMTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSALFWYNLHNNGDPNLLTRHAVCPTIVGSRWVLVKSMLNYEQMFKKPCYK
The following text describes a protein:
Function:
May play a role in apoptosis. Does not appear to show pro-apoptotic activity when expressed ectopically in early embryos.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MNVFARSSVLAAEMIDVFDRTHTEKELVFQSKELCRDFIHSRITREGLSWSKVELDLPEPRGVLVDVSVVLLKLGDELECMRPYVYRNIAKQLNISVSVEAVVSDAFLSVATEVIAMGITWGKVVAIYAVAAGLAVDCVRLGHPVMVHTIVDSLGEFVRRSLVPWLKKRGGWVDILKCVVNMDSRAHVHWLSTAVLTWREFIKTMYVYLTK
The following text describes a protein:
Function:
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Subcellular Localization:
Mitochondrion.
Sequence:
HLDALSQSTGPPPNTLLLCEHPPVYTTGIRQGPYPAQEEWRLKGHGADFFRTDRGGLITFHGPGQLVCYPILHLGCFRKSVRWYVCQLERTVIGLCGKLGIAASTSPDTGVWVGDKKICAIGIHCGRYITSHGLALNCNTEMSWFEHIVPCGIVGKGVTSLSRELKRDVTVAETIQPFLDAFAEEFNCILS
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit.
Sequence:
MKVLCGDELGQIKLVNIAKGVDTSNPDSEKPEIVRVPSTDRKQRVLFMSKLDEDLVIVLRADGILEKRNVNDVTEFIDSWKVPDDIWEDGNVVSFTFSHHWIFIAFAGGKLCFRNLVTEEIRSLSVKGPISAAAVHPRIPGVVAVGGNENDIAIYSCNEELDDNYSTSSLWDSATWKCIFKGKNVKNDRLDLRVRIWITGIAFTESITQEKDGMVTVKDKKNPLLQFATVTHYGHLRFYNTTKSRRPNVSMDISQSPLTLLRSIPNTQCLAASDKKGRVFLFDYAKSRIVGNFLGVKGSATCIDCSHGLVGIVGLDRNVRIYTNERKPLANAYIKILPTSILILDERDTAEIKQEEEQVKDEQEEEEFWEGIQQLHNEEEEKPRVKKQKVSSRSS
The following text describes a protein:
Function:
Exhibits progesterone 6 beta-hydroxylase activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MDLIFSLETWVLLAASLVLLYLYGTSTHGLFKKMGIPGPTPLPFIGTILEYRKGIWDFDIECRKKYGKMWGLFDGRQPLMVITDPDMIKTVLVKECYSVFTNRRSFGPVGFMKKAVSISEDEDWKRVRTLLSPTFTSGKLKEMLPIIAQYGDVLVKNLRQEAEKGKPVDLKEIFGAYSMDVITGTSFGVNIDSLRNPQDPFVKNVRRLLKFSFFDPLLLSITLFPFLTPIFEALHISMFPKDVMDFLKTSVEKIKDDRLKDKQKRRVDFLQLMINSQNSKEIDSHKALDDIEVVAQSIIILFAGYETTSSTLSFIMHLLATHPDVQQKLQEEIDTLLPNKELATYDTLVKMEYLDMVVNETLRLYPIAGRLERVCKKDVDINGTFIPKGTIVMMPTYALHRDPQHWTEPDEFRPERFSKKNKDNINPYIYHPFGAGPRNCLGMRFALMNIKLALVRLMQNFSFKLCKETQVPLKLGKQGLLQPEKPIVLKVVSRDGIIRGA
The following text describes a protein:
Function:
As part of a BORC-like complex, it may play a role in the movement and localization of lysosomes at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motors, driving lysosome movement toward the cell periphery.
Subcellular Localization:
Lysosome membrane.
Sequence:
MEDQEMQLKVKRVTDKFTESMYVLANEPSIALYRLQEHVRRSLPELVQHKTDMQSWEEQSQGAIYTVEYACSAVKSMTNSSLYFKNIDGLLRQAISLKEQISSSQGRSAVINPNETPAHTSVTP