lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
VLGFPPGRPQLPVQLRPQTRMATALRDPASVPIATEVLFKLTQGSVTFEDVAVYFSWEEWDLLDEAQKHLYFDVMLENFALTSSLGLTLSWSHVVAQLGLGEVPSVLHRMFMTPASARWDQRGPGLHEWHLGKGMSSGCWCGVEHEETPSEQRISGERVPQFRTSKEGSSSQNANSCEIRCLVLRDILHLAEHQGTNCRQKLHTCGKQFYISANLQQHQRQHITEAPFRSYVDTASFTQSCIVHVSEKPFTCREIRKDFLANMRFLHQDATQTGEKPNNSNKCAVAFYSGKSHHNWGKCSKAFSHIDTLVQDQRILTREGLFECSKCGKACTRRCNLIQHQKVHSEERPYECNECGKFFTYYSSFIIHQRVHTGERPYECPECGKSFSQIYSLNSHRKVHTGERPYECGECGKSFSQRSNLMQHRRVHTGERPYECSECGKSFSQNFSLIYHQRVHTGERPHECNECGKSFSRSSSLIHHRRLHTGERPYECSKCGKSFKQSSSFSSHRKVHTGERPYVCGECGKSFSHSSNLKNHQRVHTGERPVECSECSKSFSCKSNLIKHLRVHTGERPYECSECGKSFSQSSSLIQHRRVHTGKRPYQCSQCGKSFGCKSVLIQHQRVHIGEKP
The following text describes a protein:
Function:
Required for male meiotic division and spermatid differentiation. Required for accumulation of aly and comr on chromatin. May function as a transcription factor.
Subcellular Localization:
Nucleus. Note=Binds to chromatin.
Sequence:
MKVKVSGEYTLAEIEVELDQQLTPDDLQPGATVLATNESTGGLERIVSHEELSRFFAVGPAGALPMPTDVVVERTLADPAFKQILQEADGKKGFDPQAEQMKIRDFLAGVTSSKMTTEQSVFHGSRSNSSASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAPPAPLSKPASERVIRENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLETAAAQKAQSHNPEQQDNDVAGGASTSDVPSGSGFMSTEPSVAEMQYSITPEQQEEMVCVPIDEVNNSFFMSHYMQAVPMEEDGSGQHIIVFEQPGQNMDMMSIYDQQQVGEPMHESGVPKRPAEENARVVVVKNNPTKPIFSDTYL
The following text describes a protein:
Function:
Part of the propionyl coenzyme A carboxylase (PCC) complex involved in propionate utilization and in the production of the poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV), which is a water-insoluble biopolymer used as intracellular energy reserve material when cells grow under conditions of nutrient limitation. The complex catalyzes the carboxylation of propionyl-CoA to methylmalonyl-CoA. PCC is also able to catalyze the carboxylation of acetyl-CoA.
Sequence:
MTMEDRIDELREKREEALKGGGEDRIASQHDKGKMTARERIDYFLDDGTFREFDQFRTHRNHKFGMEETKLPGDGVITGHGEVDGRTVFVFAHDFTVFGGSLGEVFAEKICKVMDKAMEVGAPVIGLNDSAGARIQEGVQSLGGFGEIFRRNTEASGVVPQISAIMGPCAGGAVYSPALTDFTFMVRDTSHMFITGPDVIKTVTGEEVTFDELGGATTHTSTSGVAHFATDTEEQALDDIRHLLSYLPQNNVEDPPRVEPWDDPERVADELEEIVPDQPRKPYDIHDVLNGVLDEGSFFGVQEDFAKNIVVGFGRLDGHSVGIVANQPRVNAGTLDIEASEKGARFIRFCDSFNIPILSFVDVPGFLPGTDQEHNGIIRHGAKLLYAYSEATVPLMTVITRKAYGGAYDVMASKHLGADVNYAWPTAEIAVMGPQGAVNILYRDELEAADDPDARRDELIEEYREEFANPYTAADRGFVDDVIEPGDTRNRLIADLRMLKSKRKSQPDKKHGNIPL
The following text describes a protein:
Function:
Is associated with a DNA binding complex that binds to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes.
Sequence:
MKEREKVVRLAKLAEQAERYDDMVEFMKTLARMDVDMSAEERLLFSVGFKKTIGARRASWRILESLEQKVTAGDQPGVTINGYKKKVEDELRAVCNEVLSIIAIHCLPLANSGENVVFFYKMKGDYYRYLAEFSTGTEKKAATDQSLMAYQAWPCAQLFSLLEIMNSPERASQVAKQALDEATAEINSAGVEGYKDSMLMMQLLKENLALWTSELTGGETSKDDDVVMEG
The following text describes a protein:
Function:
Plays a role in the definition of cell polarity via the planar cell polarity (PCP) cascade. Acts downstream of fuz and accumulates asymmetrically in wing cells to regulate planar polarity in the wing. Probably acts by regulating ciliogenesis.
Subcellular Localization:
Cytoplasm. Cell membrane. Note=Localizes in the vicinity of plasma membrane and the cortical actin cytoskeleton of wing disk and pupal wing cells. Localizes to the proximal side of wing cells, fuz and frtz are required for its localization.
Sequence:
MRKSPASLPSEAFSSSNSSLSNSYSDGSDLANWEEYVSTDGSLFYMEYVRCEKTGVSAERRVEFMRRSLRLGKKSSRRQPHSNNQNQSQNQNQSHGPSRLDSQTEPQEFRFSQFKTAAPDPKKLDLVITAADRFRFGRRSTAVESILGFRVLPFPDQPECLMVDGFVHDVSALQHGIKRGDWFRSLNGIEVYASNVDELLKQFVEPTQVCLGFQSCGAASAVSPTDPGYNRNVREEQVCKVENFPMFTEKFEQMLITEGNFGIPGSSVDIRMPFAMLLLPPECYQHEQQQDSLYYFPEIPDNFLFKARGSFLTLHAVLSELHTQPLSSRLLVDQVQYHVNYRQLNGFLVLFAYAGGLCCAAECSLRSDELIGYIRFSLPGLVLESFNQEREPGNSSRLKLFLRHFCEIQRTRLVARCHGHIRFEELLGQSRSLPLPKEAQLRIFDALSEMEAMDYRNWNDEPLTTHREFFIYGSALYYDGFLVASLLPPEVRVSVEGFLRCRGIFELLGAAPGIKVREMYVWEEIVLPSATGRYFLTICTKNHLSLAVILKIFDAPDMAPDAVVGPSLFYIEEIQETLDHLVQCGIESLAMFWSVSNKRPEVLDATASESRDQEKEPNNRLESFLKQKLTVLSPSVEEEAQLCSSLGGSSIHSLTPSEDESCRRRLTPIHGTAEDSDSGSDWENFAVQHPLHYGLNLGAESHSQSQMTESMWKEINNVVPVKISAGWKNSVLHYVYIDIANGSLFAPFTDSSENSNYLSEIRQACHIIHAVLQKSKHYRRHLSESSRAQTNSNGHSSHTVSLVKEHGMILEVSTQPKSDGQSQSSTSSRFVVVGRLFQSPAKEVYVCHRSDVPQNIVEMAFRLSFFSMG
The following text describes a protein:
Function:
Alkylbase DNA glycosidase-like protein that shows no DNA glycosylase activity for alkylated bases. The molecular role of mag2 appears to be abasic (AP) site recognition and protection, while possibly facilitating damage signaling by structurally sculpting the DNA substrate. Stimulates AP site binding to mismatch repair protein mutS.
Subcellular Localization:
Nucleus.
Sequence:
MSKDSDYKRAEKHLSSIDNKWSSLVKKVGPCTLTPHPEHAPYEGIIRAITSQKLSDAATNSIINKFCTQCSDNDEFPTPKQIMETDVETLHECGFSKLKSQEIHIVAEAALNKQIPSKSEIEKMSEEELMESLSKIKGVKRWTIEMYSIFTLGRLDIMPADDSTLKNEAKEFFGLSSKPQTEEVEKLTKPCKPYRTIAAWYLWQIPKLHRKGQ
The following text describes a protein:
Function:
DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAGVDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEAAKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEIEVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIPVRLADLETHVLRTFYQKNHV
The following text describes a protein:
Function:
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Miscellaneous:
MISCELLANEOUS: More highly expressed in DDT-susceptible strains (Canton-S and 91-C) as compared to the DDT-resistant strains (91-R and Wisconsin).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MELVLLILVASLIGIAFLALQQHYSYWRRMGVREIRPKWIVGNLMGLLNMRMSPAEFISQLYNHPDAENEPFVGIHVFHKPALLLRDPEMVRNILVKDFAGFSNRYSSSDPKGDPLGSQNIFFLKNPAWKEVRLKLSPFFTGNRLKQMFPLIEEVGASLDAHLRQQPLHNERMRCFDLEAKELCALYTTDVIATVAYGVSANSFTDPKCEFRRHGRSVFEFNLLRAAEFTLVFFLPHLVPFVRFKVVPAEATRFLRKTINYVMSEREKSGQKRNDLIDILIEFRRSTQLAKASGIKDQFVFEGDILVAQAVLFFTAGFESSSSTMAFAMYELAKDTDVQQRLREEIKDALVESGGQVTLKMIESLEFMQMILLEVLRMYPPLPFLDRECTSGRDYSLAPFHKKFVVPKGMPVYIPCYALHMDPQYFPQPRKFLPERFSPENRKLHTPYTYMPFGLGPHGCIGERFGYLQAKVGLVNLLRNHMITTSERTPHRMQLDPKAIITQAKGGIHLRLVRDALGV
The following text describes a protein:
Function:
Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Secreted, extracellular exosome.
Sequence:
LHGDIKAIKLLLLWSSAQKAFLAPCINQNSIPPEDLDGSSDDEDFSGSGDGTGKKGLYTEETIRKTILNISPDKQIGQTDKDIYLYYCLALQFFFPFPVFDTPTPSEDELHLNVTATPVVLKTTESPKLHEAEEQRTTSLAPVSSSKVTTMPVSTASPDTTVMPQIPVQEPTSAKPETTTRDVASPPIVDVATSAPSAADTPRGSTTAEMDFPHSEDLEPTTAAHSSSATLPSDDQSADPFVKGTSVVTVAAPSQPPTTAGAEDVTFREDSVLSSTIPVHTTQPSIELIPENEIHPNPRMVNTEIHSILATIKPEKPIEKLLVELANPIYSYYSETSEQAASEGLLENKEVLAGVIAGGIIGLAFAVLLVALMVYRMKKKDEGSYALDEQKHSNGGYQKPQKQEEFLA
The following text describes a protein:
Function:
May reduce intracellular freezing damage during winter by hydrogen-bonding to the lattice of the nascent ice crystals, thus modifying the structure and/or propagation of ice crystals.
Domain:
Contains 7 A-type repeats and 14 B-type repeats similar to those found in maize, rice and barley dehydrin and rab proteins.
Sequence:
MDHQAHGAGEKKGIMEKIKEKLPGGHGDHKETAGAHGHAGTVTHGAPATGGAYGQEGHTGTTGTGLHGAHAGEKKGVMENIKDKLPGGHADHQQTGGTYGQQGHTGTATHGTLATGGTYGQQGHTGTAMHGTPATNGTYGEHGHTGTATGGSYGEQRHTGVTGTGTHDIGEKKSLMENIKEKLPGGHGDNQQTAGTYGQQGHFATGTHGTPATGGTYGEQGHAGVTGTGTHGTGEKKGLMENIKDKLPGGHGDHQQTGGTYGQQGHTGAATHGTPAGGGTYEQHGHTGMTGTGTHGTGGKKGVMENIKDKLPGGHSDNQQTGGAYEQQGHTGAATHGTPASGGTYEQHGHTGMTGTGTHGTGEKKAVMENIKDKLPGGHGDHQQTGGAYGQQGHTGTATHGTPAGGGTYEQHGNTGMTGTETHGTTATGGTHGQHGHTGTTGTGTHGTDGVGEKKSLMDKIKDKLPGQH
The following text describes a protein:
Function:
Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome.
Sequence:
MATASGASDLSGSGAPPPGVGAQAAAAAEEEEREVVRVRVKKCESFLPPEFRSFAVDPQITSLDVLQHILIRAFDLSGKKNFGISYLGRDRLGQEVYLSLLSDWDLSTAFATASKPYLQLRVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLDHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGHRGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLSEPLLNSPDPLLSSFSHPDSPSSSSPPSTQEPSPTGDMAVGSPLMREVGSPKDPGKSLPPVPPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARALFADYLQSEVWDSEEGAEATAAS
The following text describes a protein:
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Sequence:
MSSPGIDGDPKPPCLPRNGLVKLPGQPNGLGAASITKGTPATKNRPCQPPPPPTLPPPSLAAPLPRAALAGGPCPLAGGPASALAPGPPAERPPLATDEKILNGLFWYFSACEKCVLAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYALSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQDFGLKHLLALGSLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPRCLVIE
The following text describes a protein:
Function:
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MKLFNFYNKSVYIQYRNQLCSTTTVVVCALTLAAFAVPYYLLSSIRQGELWDQQRTVYEQPKMSFQYSYLFLAEMEDSEEGRATSASVVTCSSFPSYNTLTEQLHPCSDVQVIPTDTNHDHTLDHLSVSVSFNPPDRASRLSFYTFYFFLEATVSSQCRFVIPAFVSLEKVPPPAARTFLSGTIVHSGLMATRQTVALQCPFFMRHQQSHFSDRYYPNENTTLDGFQPRVIRAQIEAANPAYYEYRPQHIDWTMDGSGTVRVQVDVAIGGNESTSVALLYKTSLWWKLCQFWGSYFPLLIVSLWLAEKSKQYLFERFFLRAVEVVPWKNKYN
The following text describes a protein:
Function:
Vesicle SNARE required for retrograde transport within the Golgi complex.
Miscellaneous:
MISCELLANEOUS: Multicopy suppressor of sed5-1.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MSNSRYSQTESNNDRKLEGLANKLATFRNINQEIGDRAVSDSSVINQMTDSLGSMFTDIKNSSSRLTRSLKAGNSIWRMVGLALLIFFILYTLFKLF
The following text describes a protein:
Function:
May be required for posterior development and development of normal embryonic axial pattern.
Subcellular Localization:
Nucleus.
Sequence:
MEGRKEMLMYLEGGQLGTLVGKRMAHLSDAVGSPMAESQDKLVPKSPRAGPIAPTDRAEESEVEVGQATGQQRSRSPQLRISSPHPPAHSDSLSTKGQHSSSDTESDFYEEIEVSCTPDCNSAASDYQQHSAGQCSEPMGGSPVNGSDSSKGGGGSHGSFSACAGDQMRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMTWPHPADPAFYTYMMSHAAATGNLPYPFPSHLPLPYYSHMGISAGSTAAATPFSAPLRPLDTFRVLSHPYPRPDLLCAFRHPSIYASPAHGLGSGGSPCSCLACLSTSTNGLGQRAAASDFTCSSTSRSDSFLTFTPSILSKSSSVSLDQREEVPLTR
The following text describes a protein:
Function:
Part of a complex with lis-1, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells. Plays a role in GABAergic synaptic vesicle localization in the ventral nerve cord.
Subcellular Localization:
Nucleus envelope. Note=Recruited to the nuclear envelope by unc-83.
Sequence:
MDLSEDQIRGLPHHELLGHFLQMREEFNEFQTSSAEIEKMMDSELDDLKTQLKKAETRVQQMTTEQIRNKDRQDDSRVQFAQVEEQLRRENSHLHEQCESQRERIRKLEQRNDVLETSERNKEYLASDLGSKLDHAIEKIAMLESELYERQVAAEEMHRLREEQLRTTERPRLIVEPLRNDPEILPDEPSPGPSKEEFKMSSEDVFMEDVQHHEDVRMEETIAKIDEVRIDDNKNIQEKSQRVSTGTGAGACINRIVKDLMTKVERLDSILSTIRVSNNSSNNNSSHLTTTRA
The following text describes a protein:
Function:
Transcriptional regulator that, together with ECM5, recruits histone deacetylase RPD3 to a small number of promoters of stress-response genes in response to oxidative stress. Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes to promoters of stress-response genes in response to oxidative stress.
Sequence:
MPKEEDFQLPRRREAAKNVNYNEMEIDTKLVQQIQIAEKSGAKTKGSNSQTPRNCKRTSNPASRNEKFKYQKFLHDKNTCWNFIPTLPPSFRKNSRFSNILDLDDAMIDLKKMSLFNTESVLLSANDTIYMISEPAGEPYYVGRVVNFVSKPEFSNTIHEAIKTTSVFPAKFFQVRMNWFYRPRDIQEHVNTFNPRLVYASLHQDICPISSYRGKCSIFHKDEVFDVLPNEKECIIRPNIFYFDELFDRYTLKYYKVYSTDKILNKWNSKSPFLYVLNRRFRYIYTEPKYPLENVLKKYVFHELEVNELSPADYQWDKRCQFCKEWCIQKESLSCDECGVCAHLYCMDPPLDRKPNKDVVWTCFSCLQKQQGTKDSHVRFLEEQALELDFIRSVRQKIEEISSKAIKENVGYNTENCWFQYLGIYSISHIGDALNDSMFFPYPFKPSRVGVKYQWNGCNHNVPWRRNSYISANSEEERGSTKTSELAWVLDASKITTRKLSEYIEQCKSEICPILNVRGETCNFIDVVLKNLLFTNYDTAEAFKKCKRELSRKFLKEPSFTAVEIRKFEEAVEKFGSELRPVCEYVGTQPMSMIVRFYYNWKKTERGLTVRGKLSKLSKNKRKKEIANHENDVETKYIDDSSFDTEKLSLAESSFQCMFCKTDYSPMWYRVTGGSDDEKIKIRMQTGVNEKTEISEKSPAHSKKNEKLGALCIRCARMWRRYAIKWVPPLETLRKITGTCQNSFYSAIEGIIEENNTNKFTLSPFQAHNKLLEWELVQDSELIIRQRMKVYKNPNSFVKMKRYSMTFHTQLYKMAVRSYRKNEFHPETMQRDLELFIEDNKEVRKAIPEQKPERAKNTKDEFPVNIIRQSPGTIKTSDTSRNRKCNDVFIEKASNNNIPKITNASNDLIEISIKTGGSSSGSVSVDKGFKFVKFDNKTFQRLRNSLKLVNNKLPKYNEPSTKKIKMINDIALSNPLNEPNGASYNYTVISHSKETSVALEKYHDGNKPSKMLEKDMILKHTKNKPKNPDTAWANNSARTFCSVCKEKFNDNDNYEVVCGNCGLTVHYFCYAIKLPKDMKKNTNLKTFKWLCDPCSNDLNPIISTTYQCSMCPTKDYDYDRYRSQSFKICPDALKCTSLGTWVHLVCSLFNEDIKYGNGQSMQPALNTTAVLIKHSRFTCGVCRINGGGLVKCNKCQYRYHITCAQNSSNFKLMFEKKNMSVDTTLPCIKDVKLNDTYTLRPILICDRHDISLEGNELYPLSYKPQHTLSYIEQYCRYYKCESDHSLVELRYFEQLRLRHGEMPGNSHDSAIKPKIYVLPFERTCPHCGTNKSLYWYEDIICHSCNLRSGAQELDFDSASANISNDNGLPVEITQQLMEGIEPAMFDIDISEAGTDKNTHPSSQ
The following text describes a protein:
Function:
Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal.
Sequence:
MNKPQLPDFIQNKIDHYIENYFDINKNGKHLVLGKQASPDDIILQSNDYLALANHPLIKARLAKSLLEEQQSLFMSASFLQNDYDKPMIEKRLAKFTGFDECLLSQSGWNANVGLLQTICQPNTNVYIDFFAHMSLWEGARYANAQAHPFMHNNCDHLRMLIQRHGPGIIVVDSIYSTLGTIAPLAELVNISKEFGCALLVDESHSLGTHGPNGAGLLAELGLTREVHFMTASLAKTFAYRAGAIWCNNEVNRCVPFISYPAIFSSTLLPYEAAGLETTLEIIESADNRRQHLDRMARKLRIGLSQLGLTIRSESQIIGLETGDERNTEKVRDYLESNGVFGSVFCRPATSKNKNIIRLSLNSDVNDEQIAKIIEVCSDAVNYGDFYFR
The following text describes a protein:
Function:
Involved in the biosynthesis of spiroketal steroid and saponin natural products from cholesterol such as diosgenin and analogs (e.g. furostanol and spirostanol), plant defense compounds used as main precursors for the industrial production of steroid hormones. During the 5,6-spiroketalization of cholesterol, catalyzes the hydroxylation of cholesterol to form 16S,22S-dihydroxycholesterol and, possibly, the subsequent conversion of 16S,22S-dihydroxycholesterol into 16-oxo-22-hydroxy-cholesterol and 16-hydroxy-22-oxo-cholesterol. 16-hydroxy-22-oxo-cholesterol submit a spontaneous reaction leading to the production of furostanol-type steroid diastereomers, precursors of diosgenin.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MAPVVILFFLFPTLLVLVVAVLGLRGGDDSWKKRGLKVPPGSMGWPLLGETIAFRRLHPCTSLGEYMEEHVNKYGKIYRSNLFGAPTIVSADAELNRFVLMNDERLFEPCFPKSVADILGHTSMLVLTGEMHRYMKSLSVNFMGIARLRNNFLGDSELYITQNFNRWKENIPFPAKEEACKVTFNLMVKNILSLNPGEPESEHLRKLYMSFMKGVVAIPLNLPGTAYKKAIQSRATILKMIEKLMEERIRNKKAGTDKIGEADLLGFILEQSNLDAEQFGDLLLGLLFGGHETSATAITLVIYFLYDCPKAVDHLREEHLGIVRAKKARGEPPALTWDDYKQMEFSQCVVSETLRLGNIIKFVHRKAKTDVQFKGYDIPKGWSVIPVFAAAHLDPSVYENPQKFDPWRWQTISTGTARIDNYMPFGQGLRNCAGLELAKMEIVVFLHHLTLNFDWEMAEPDHPLAYAFPDFPKGLPIKVRRLALK
The following text describes a protein:
Function:
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MNRGGRGGFGGGRGGAGGNRGGFGGGRGGGRGGNSGFNKGGRDGGFDNGNTIEIGTFEYLANNTAVYHLSSKDNVVPLTQTFLMDANKNKVGKVGDVFGPLTDVRFNLVPEDNSYLKKLKVGDKIYAPENRCHPESFYTDDAPAPKRGGRGGGRGGRGGRGGGRGGGRGGRSGRGGH
The following text describes a protein:
Function:
This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MYISRNLEQWNAFLQMLKIAFEENKAQEFLTLLLTADERDAVGLRLQIVSQLIDKNMPQREIQQNLNTSAATITRGSNMIKTMDPDFMQWMKQHLDLIEKN
The following text describes a protein:
Function:
Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons. Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy. Lipid transfer protein required for lipid droplet degradation, including by lipophagy. Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown. May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis.
Subcellular Localization:
Cytoplasm. Lipid droplet. Midbody.
Sequence:
MDALRKNHDEAFLYVAQGLSYEERGEHALAAEMYQKGLERLDTALGVRAELPDCEGPQWDEVRTLQRKMCSIRNEVEFRLQAIAEAGSNDALFADRPPSYDEAVGGTQQQQLDRNRGHYRDAEVLLSIDGATVGILLPSDLSPEMHAVFESLMEDLTAMKIQSIVLRGETRNLEALSEPVRVRRDLRFSQKISDGIVSGSEMLSKGLNRGAVLTSEALRMGAVRLKQYLQPSAGPVPVDPRIKQGMELLRNVTGSVRGVSEVVVNKVGDLAVALGQRVAKNVACEGCVATTSGAGAGGTMNDVFVIASGGVRGVSTLYMGLENAAKTLASSLANETVQIVGHKYGQDAAQVVDHAIYSVGNVALTTNSVRSLGVRGLAKRTAKETGKAILEEYVSSLERDPRFSGDPLVASLRMQPK
The following text describes a protein:
Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGKKLVMAQKRGETRALCLGVAMVVCAVITYYILGTTVLPLYQKSVWTQESTCYLIETNIRDQEELEGKKVPQYPCLWVNVSAVGRWAVLYHTEDTRDQNQQCSYIPGSLDNYQTARADVEKVRAKFHEHRVFYCFSTTRENESSVLYRRLYGPQTLLFSLFWPTFLLTGGLLVIAMVKVNQSLSILAAQK
The following text describes a protein:
Function:
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
Sequence:
MKEILAWREINLSFLLDNLKVIKEKVGGKVDVIAVVKADAYGHGAKVISLFLQKYANINTFAVAHIDEGIFLRKIGVNKKILVLSPQLKSSIPYYFEYELTPVISDIEFLDELGKYSNNKDKKLKVHLIFDTGMGREGFLPSESEEILKLLRRYPNLILEGISSHLSNPENKKDPYNIFQKKLFYDIYNQFKDEDLVFHFSNTGGIFNFPEFHFNAVRPGISLYGYGDKLLKPVMEIKARITLVKELPEGWGVGYGHTFMTEKSTKIAIVPLGYADGYRRDLSNKGRVIVNGEYCKIIGRVSMDQFTIDITDKEVKRGDLVTVMGRENEKMVDAQELAILSNTIPYEILTGFGSAKRLKSIYKFQGKVLNDPITELNL
The following text describes a protein:
Function:
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.
Miscellaneous:
MISCELLANEOUS: Vitamin B12 is bound in a deep cleft formed at the interface between the two lobes of BtuF.
Subcellular Localization:
Periplasm.
Sequence:
MAKSLFRALVALSFLAPLWLNAAPRVITLSPANTELAFAAGITPVGVSSYSDYPPQAQKIEQVSTWQGMNLERIVALKPDLVIAWRGGNAERQVDQLASLGIKVMWVDATSIEQIANALRQLAPWSPQPDKAEQAAQSLLDQYAQLKAQYADKPKKRVFLQFGINPPFTSGKESIQNQVLEVCGGENIFKDSRVPWPQVSREQVLARSPQAIVITGGPDQIPKIKQYWGEQLKIPVIPLTSDWFERASPRIILAAQQLCNALSQVD
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.
Subcellular Localization:
Cytoplasm. Nucleus membrane. Nucleus, nuclear pore complex.
Sequence:
MACCCYSTILTHTRLDFKTMHQNALNNATLNVLGHKKNGSSSIQELIEMDEEEAEMNQNVVCIGPNETAVSVELGDEYEKFNIITSLKKDNLFSKDGLLYAYYELCQEKFEKCLKEDDEEWIELWDLESRTWDLIQRLYSFRLSEQQGHIQSHAFSSRAVLEEEYYSQNPEAFENNIVFNWARDNSSDPPSIEIRGNRWFYTREDIKMKNRGGSRFSSNISGTIVSNLDPDADIRDDKRLDERDDNFERQFFHTAFCLFRSGSFEELLELCRRTGNHWRSASLQGILEYRDNLIDDVLQSETSGNKRKELLRRSCLALTKNKRIDSYERALYGALCGDLNSVLDVCTTWEDAMWAYYNSMTQYNLDVYLSSKAPQTETQLPPVDSGLGLTPELIFNSLSNSSIASIQEEASHPLIKLQTHIICNKISEILSSAHIQLEAIRTGNAPESGDLVTPPLLRILTHIILFLKISGLAVDEYTSDSIIQAYIELLASAKKVNLVPLYIQYLSNQVQYEAYSRFLILVDEESARSEQLQLAKKYSLDINHAALLAVEYVYDEVVSVSPEEVHTVYLKSIEEPVEPSYKKLICTLEWLLITSQTDELLRFANLVYRFFLSIGELNSAYDLYTHIPSDALNTLSSSDGEPENDSKFRDAYELMNYRALCRALKFYQEWEELSKQEVFEDSAVTKASTSYKVWKKKLNFASRKCVKSFTDLLQANWLHPSTLELKPDDDPLLYKTLMTIRNLYVPELILGLHNVYFSLEDYDSCFALANEVASEDLKLYHCLIKSGRLVEYVSYLGKAGECSLSTPNGLFSL
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Subcellular Localization:
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Domain:
Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
Sequence:
MEVTKPHACLREVVVTIPRGEVDRYMKDAYDELVPEAQVPGFRAGRAPRKLVEKQFKDRIEDRVKGSLLMDSLAKVTEDAEFSAIGEPDFDYESIELPEKGEFKYQFSIEVRPEFETPDWKKLELKKPVETISEEDVDAALQRVLSRYASLEASDAPAEIGDRLLITGKFVDGEKTISEMDEERVTLANRLSLSDAVCENFGELMKDCKEGDVVTGKVKLGEGHANEEMQGKEVDATFTVVEVLKEQLPELTSEFLDELGEFETEDELREFVRASLERQANFRTEQAMRGSIIEKLLASADFELPPTLVRRQMKRELDRKVLEFRRSGFDDDMIRRFVNASKQNMQQGTESSLREHFILEQIADEEKIDAEPQEYETEIQLIAEQSDSSPRRVRARLEKTGQMDALRNQIVERKVIELISEAATVTEEPVEKEAEEKNEEFAIDHEVLPTKDHDAIPAAKYDDNTPKGAETEDKQEKDKD