lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Synapse.
Sequence:
MWLVTFLLLLDSLHKARPEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFIVRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEGIKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPGTNPVSRKNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDTDKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNENADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFFRKADGREPCPVVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHPGAPAAASTATLPQRTLAMPAPPAGTAPPAPGPTPAEPPTAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMSTSGVGRSQKQGAGAYSKSYTLV
The following text describes a protein:
Function:
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular Localization:
Cell membrane, sarcolemma; Single-pass membrane protein. Golgi apparatus. Cell projection, dendrite. Cytoplasm, cytoskeleton.
Sequence:
MLLFWWWELGDPCAWTGKGRGTLKMSPATTGTFLLTVYTLFSKVHSDRNVYPSAGVLFVHVLEREYFKGEFPPYPKPGEVSNDPITFNTNLMGYPDRPGWLRYIQRTPYSDGVLYGSPTAENVGKPTIIEITAYNRRTFETARHNLIINIMSAEEFPLPYQAEFFIKNMNVEEMLASEVLGDFLGAVKNVWQPERLNAINITSALDRGGRVPLPINDMKEGVYVMVGADVAFSSCLREVENPQNQLRCSQEMEPVITCDKKFRTHFHIDWCKISLVDKTKQVSTYQEVVRGEGILPDGGEYKPPSDSLKSRDYYTDFLVTLAVPSAVALVLFLILAYIMCCRREGVEKRDMQTPDIQLVHHSSIQKSTKELRDMSKNREIAWPLSTLPVFHPVTGEVIPPTHTDNYDSTNMPLMQAQQNLPHQTQIPQPQTTGKWYP
The following text describes a protein:
Function:
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Sequence:
MEFVKEFATFLHQKGIIKFGDFTLASGKKSSYYVDLRLVPSYPQEFRKMVKYLENEIAQNIGLDKFDSIVSVPTGGLVIASALAIETVKPLIYVRSKPKDYGTSKSVEGKIHDGMQVVMIDDVATTGGSVVNAIKSLKEVNISVKDAYVIVNRMEGADEALNELDVKMHSILNILQITEALHEQNLVDDEILEKVKNQIAK
The following text describes a protein:
Function:
Involved in recombination ability and DNA strand transfer activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MGRLSWASPIQRFRFFSYLSQLNGRRSVLACSGYENRYLSSLVEASDCELDEVPDDRKVAEKDTALHLALSQLSGDFDKDSKLSLQRFYRKRRVSVISTGSLNLDLALGVGGLPKGRMVEVYGKEASGKTTLALHIIKEAQKLGGYCAYLDAENAMDPSLAESIGVNTEELLISRPSSAEKMLNIVDVLTKSGSVDVIVVDSVAALAPQCELDAPVGERYRDTQSRIMTQALRKIHYSVGYSQTLIVFLNQVRSHVKSNMHFPHAEEVTCGGNALPFHAAIRLKMIRTGLIKTANKISGLNVCVQVVKNKLAPGKKKSELGIHFGHGFYVEREVLELACEHGVILREGTSYFIEGEVIEGKDAAEKYLVENKEALDTVVAILRNQLFKM
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
Sequence:
MLLDLSGRVAIVTGGSRGIGRATAERLAGSGAAVVVNYRGNAAAAEATVAAITAAGGTAIAVQGDVSQPADVEQMVKTTLERFGRIDILVNNAGITRDTLLLRMKESDFDEVIATNLRGVFLCTRAVLRPMTKQRFGRIINITSVVGLTGNVGQANYAAAKAGILGFTKSTAREMASRGITVNAIAPGFIETEMTEALNEEARKAILATIPLGRFGQPAEVAGLVCFLASDAGAYISGQTLTIDGGMVMS
The following text describes a protein:
Function:
Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Also mediates the exchange of L-cysteinesulfinate (3-sulfino-L-alanine) for L-glutamate. Necessary for gamma-aminobutyric acid (GABA) uptake in brain mitochondria in response to increased mitochondrial membrane polarization; does not possess detectable GABA transport activity but role may be indirect; [Isoform A]: Possesses transport activity towards L-aspartate, L-glutamate and L-cysteinesulfinate (3-sulfino-L-alanine). L-glutamine transport activity is undetectable. GABA transport activity is undetectable; [Isoform E]: Possesses transport activity towards L-aspartate, L-glutamate and L-cysteinesulfinate (3-sulfino-L-alanine). Has a wider substrate specificity range that includes L-2-aminoadipate and L-glutamine. GABA transport activity is undetectable.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Domain:
Upon calcium binding, the EF-hand-containing regulatory N-terminal domain binds to the C-terminal domain, opening a vestibule which allows the substrates to be translocated through the carrier domain. In the absence of calcium, the linker loop domain may close the vestibule, which may prevent substrates from entering the carrier domain.
Sequence:
MPMHIPFPFNWIPTLPVARCQESPSLLKRAGTEKLREVFLKYASIQKNGEHYMTSEDFVRKFLGLFSESAFNDESVRLLANIADTSKDGLISFSEFQAFEGLLCTPDALYRTAFQLFDRKGNGTVSYADFADVVQKTELHSKIPFSLDGPFIKRYFGDKKQRLINYAEFTQLLHDFHEEHAMEAFRSKDPAGTGFISPLDFQDIIVNVKRHLLTPGVRDNLVSVTEGHKVSFPYFIAFTSLLNNMELIKQVYLHATEGSRTDMITKDQILLAAQTMSQITPLEIDILFHLAGAVHQAGRIDYSDLSNIAPEHYTKHMTHRLAEIKAVESPADRSAFIQVLESSYRFTLGSFAGAVGATVVYPIDLVKTRMQNQRAGSYIGEVAYRNSWDCFKKVVRHEGFMGLYRGLLPQLMGVAPEKAIKLTVNDLVRDKLTDKKGNIPTWAEVLAGGCAGASQVVFTNPLEIVKIRLQVAGEIASGSKIRAWSVVRELGLFGLYKGARACLLRDVPFSAIYFPTYAHTKAMMADKDGYNHPLTLLAAGAIAGVPAASLVTPADVIKTRLQVVARSGQTTYTGVWDATKKIMAEEGPRAFWKGTAARVFRSSPQFGVTLVTYELLQRLFYVDFGGTQPKGSEAHKITTPLEQAAASVTTENVDHIGGYRAAVPLLAGVESKFGLYLPRFGRGVTAASPSTATGS
The following text describes a protein:
Function:
Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Within the endoplasmic reticulum (ER), localizes to the mitochondria-associated ER membrane, a zone of contact between the ER and mitochondrial membranes. Enriched in the rough ER.
Sequence:
MLYSLLLCECLWLITAYAHDDEWIDPTDMLNYDAASGRMRKSQVKYGISEKEEVNPDLSCANELSECYNRLDSLTYKIDECEKQKRKDYESQSNPVFRRYLNKILIETKKLGLPDENKHDMHYDAEIILKRQTLLEIQKFLSGEDWKPGALDDALSDILINFKFHDFETWKWRFEEFFGVDPYNVFMVLLCLLCIVALVATELWTYVRWYTQLKRVFFISFLISLGWNWMYLYKLAFAQHQAEVAKMEPLNNVCAEKMNWSGSLWEWLRSSWTYKDDPCQKYYELLLVNPIWLVPPTKALAVTFTNFVTEPLKHVGKGAGEFIKALMKEIPVLLHIPVLIIMALAVLSFCYGAGKSVNMLRHVGGPEREAPQALQAGERRRQQKIDYRPHGGAGDADFYYRGQISPIEQGPNDNTYEGRRDVLRERDVGLRFQTGNKSPEVLRPFDLQEAEAREHPKVVPGLKSPNLESKPREMGEIPGESTPTESSTESSQPAKPVSGQKVSEGVEGCPAVEKAQLRTDAAGGPEEGSTCSPASTAVEVCG
The following text describes a protein:
Function:
Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.
Subcellular Localization:
Membrane; Single-pass type IV membrane protein. Note=Preferentially associated with the early endosome. To a lesser extent, also present in late endosome, the plasma membrane and coated pits (By similarity).
Sequence:
MAPDPWFSTYDSTCQIAQEIAEKIQQRNQYERNGENTTKLTVTIRALLQKLKEKIALLKDLLLRAVATHQITQLEGDRRQNLLDDLVTRERLLLASFKNEGAEPDLIRSSLMTGGAKRGAPNPWLLEEPEETRGLGFDEIRQQQQKIIQEQDAGLDALSSIISRQKQMGQEIGNELDEQNEIIDDLANLVENTDEKLRTETRRVNLVDRKSTSCGMIMVILLLLVAIVVVAVWPTK
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
Subcellular Localization:
Cytoplasm.
Sequence:
MLIAIVGKPGVGKTSLLQYLKDNYHFSVFYADSFIHEQYQKNNPGYQLIMDHFGKEFVNQTEVDRKKLANYVFSDDKLIEKLSLVTKPLLIAWIKSLKTQFQKKLALIEIAVMLNYWNEYRSLFDYVIKLERDDQLVNLALQQRNSHKKVKDLIKEPNCKIDTIFNNDSIATAALKLIKLLETFLERNKCRCDCCHIQ
The following text describes a protein:
Function:
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (By similarity). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation.
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type II membrane protein; [Isoform 2]: Cell membrane; Single-pass type II membrane protein; [Isoform 3]: Cytoplasm; [Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted.
Sequence:
MRRASRDYGKYLRSSEEMGSGPGVPHEGPLHPAPSAPAPAPPPAASRSMFLALLGLGLGQVVCSIALFLYFRAQMDPNRISEDSTHCFYRILRLHENADLQDSTLESEDTLPDSCRRMKQAFQGAVQKELQHIVGPQRFSGAPAMMEGSWLDVAQRGKPEAQPFAHLTINAASIPSGSHKVTLSSWYHDRGWAKISNMTLSNGKLRVNQDGFYYLYANICFRHHETSGSVPTDYLQLMVYVVKTSIKIPSSHNLMKGGSTKNWSGNSEFHFYSINVGGFFKLRAGEEISIQVSNPSLLDPDQDATYFGAFKVQDID
The following text describes a protein:
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MDAIDNVFDPLRDFAKDSLRLVKRCHKPDRKEFTKVAFRTAIGFVVMGFVGFFVKLIFIPINNIIVGSG
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MRPSPTGSCIVVVGADDADSRKRRREEAEGDGGEDIDSSYTVTSTPVLRVETIHVCSAILAAKSNFFRMLFSNGMKESGHRQATVTIADSEYEAFLELLHFIYSGKLTPTEPILLVDILLAADKFEAASCIKLCGQRLIDLPMTLESAVMCLDLPCSISMAPALAEAAKKFLAKRYDKFLSTEFQDELMTVSLTGIVAILSRNHPGVASEEAVYDFVLRWARFQYPNSEERHKILSSSLLPLVPVVRSMTNGILIDQPSCIVDFTLSRRQCSGLFPSGSIRSPPFCCAGHGFFLSAHGRTGLSNCFSLLIEKLEGKGPVRGTIDYEIEAKTRPSLEFLFSWRRTTTTDSRQALGCRIPWPSIIADNSRFFVDDKLHLRVHVKITPQP
The following text describes a protein:
Function:
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
Subcellular Localization:
Cytoplasm.
Sequence:
MTFPGDTAVLVLAAGPGTRMRSDTPKVLHTLAGRSMLSHVLHAIAKLAPQRLIVVLGHDHQRIAPLVGELADTLGRTIDVALQDRPLGTGHAVLCGLSALPDDYAGNVVVTSGDTPLLDADTLADLIATHRAVSAAVTVLTTTLDDPFGYGRILRTQDHEVMAIVEQTDATPSQREIREVNAGVYAFDIAALRSALSRLSSNNAQQELYLTDVIAILRSDGQTVHASHVDDSALVAGVNNRVQLAELASELNRRVVAAHQLAGVTVVDPATTWIDVDVTIGRDTVIHPGTQLLGRTQIGGRCVVGPDTTLTDVAVGDGASVVRTHGSSSSIGDGAAVGPFTYLRPGTALGADGKLGAFVEVKNSTIGTGTKVPHLTYVGDADIGEYSNIGASSVFVNYDGTSKRRTTVGSHVRTGSDTMFVAPVTIGDGAYTGAGTVVREDVPPGALAVSAGPQRNIENWVQRKRPGSPAAQASKRASEMACQQPTQPPDADQTP
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLISSNKSIVVRRVFAEDLDNELWLIKAAILRYPFVFMDTEFPGTIFKPSKQVACEDNPVINYHYMKSNVDALQIIQLGLSLSDAQGNLPDFDSPFCYVWEFNFKDFNINRDHYASTSIELLKRQGIDFEKNKEKGIDSRDFAKKLLDYGLVFNCYGLNGITWITFHGAYDFGFMLKILTQSPLPLDLHSFVYQLAFFFGYNLKGAEETGDNLCLKQLKGFQFESAESYDTDSSNTSSLPCKFNIITIHNHSTTNDSSNSYSNHADQNAETSLPEEKMTSASPSCLSTDKQHSQQQQ
The following text describes a protein:
Function:
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
Sequence:
MKLPVVESFFSLQGEGKRIGKPSLFLRLGGCNLSCKGFNCKTLLNDEILTGCDSLYAVHPKFKTSWDYYNEPKPLIERLEDLAPNYKDFDFILTGGEPSLYFNNPILISVLEHFYRQKIPLCVESNGSIFFEFSPILKELHFTLSVKLSFSLEEESKRIHLKALQNILNNAKSAHFKFVLESQNAAQSIIEIQSLLKQLSLKNNEIFLMPLGTNNNELDKNLKTLAPLAIKHGFRLSDRLHIRLWDNQKGF
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.
Sequence:
MTTPASPTTGVQLLDVPPELAGQRIDNFLIARLKGAPKTLIYRILRKGEVRVNKGRIKPDYRLQAGDQVRVPPLRLAERDEPAPLAQGLLERMEAAIVYEDKALIVVNKPAGIAVHGGSGVSAGVIEVFRQLRPDAKDIELVHRLDRDTSGLLMIAKKRSMLRHLHEALRGEKIVDKRYHALVRGHWPAGKKNVRAPLLKNNLRSGERMVEVNVEGKDALTEFRVLRRFGDFATLVEARPITGRTHQIRVHAKHAGHAIAGDPKYGDEDFSREIRELGGKRLFLHAAQLRVPLPDGQVLELEAPVDEMWQRSLERLND
The following text describes a protein:
Function:
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Regulates the localization of S protein at cis-Golgi, the place of virus budding. May act by slowing down the cell secretory pathway. May interfere with tight-junction stability by interacting with host MPP5. This would result in disruption of epithelial barriers, thereby amplifying inflammatory processes.
Subcellular Localization:
Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal.
Sequence:
MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV
The following text describes a protein:
Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MSKSVLQAVGWVFSLGCCGATIGVTLSHKWKKNTVEGIHHSVLDSVSNVAGLWDFCQVFPSGQTQCWPIAATSVPALLLFCRILMIFGILLGCVAGFLTICSFKCTTLGPEARHAREKLSLYCGLMNLLSGICVVVATSSYIYETLNTPPSVDPRGQSVMNEVSEAAQISLAFSIIWCLASVVMIAGSTTTAEPKVKYHYPTKPIPMQEYV
The following text describes a protein:
Function:
Transcriptional activator that regulates the expression of repressible phosphatase under phosphate starvation conditions. Binds to the upstream activating sequence (UAS) of several phosphatase encoding PHO genes. Inhibited by the cyclin-CDK PHO80-PHO85 under high-phosphate conditions.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic under high-phosphate conditions and localized to the nucleus upon phosphate starvation.
Domain:
The 9aaTAD motif (residues 75 to 83) is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MGRTTSEGIHGFVDDLEPKSSILDKVGDFITVNTKRHDGREDFNEQNDELNSQENHNSSENGNENENEQDSLALDDLDRAFELVEGMDMDWMMPSHAHHSPATTATIKPRLLYSPLIHTQSAVPVTISPNLVATATSTTSANKVTKNKSNSSPYLNKRRGKPGPDSATSLFELPDSVIPTPKPKPKPKQYPKVILPSNSTRRVSPVTAKTSSSAEGVVVASESPVIAPHGSSHSRSLSKRRSSGALVDDDKRESHKHAEQARRNRLAVALHELASLIPAEWKQQNVSAAPSKATTVEAACRYIRHLQQNVST
The following text describes a protein:
Function:
Repressor of the lactose catabolism operon. Galactose-6-phosphate is the inducer.
Sequence:
MLFFAFYFGRIKRRCKMKRLEQIIKLVSEYEKIDVNTLSEKLNVSKVTIRKDLDKLESKGLLHREHGYAVLNSGDDLNVRLSINYEIKRKIVQEAVKLVSDNETIMIESGSTCALLAEEICKQKRNVTIVTNSFFIANFVRAYDSCRIIVLGGEFQKDSQVTVGPLLKEMIQTFHVHQAFVGTDGYDKEMGFTGKDLMRSEVVQYISAASDKVIVLTDSSKFDKRGTVRRFALSQVYEVITDEKLSKQNIATLENAGIMVKVVS
The following text describes a protein:
Function:
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
Sequence:
MGLGIDILKISRISRLIQRSPEWEKNFLKKCLCENEIKKYNLIKSNSSLPRLSEQAKWLAVRWCVKEAVFKALQPNFRVYMSMMEYVRTPTGYPSVVIHDPRFPLSPVMVSVSHEEDLVVANALYLPSMPKT
The following text describes a protein:
Function:
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
Sequence:
MEYLSTQEYRHIVRIVGNDIPGERKMLVGLTQIKGIGYNFATAILDTLNIDSNSNIGHLTDENVQAIEKLITNPAEGNFPTWFLNRRKDIETGNDLHLLTSDIPFTLRNDIERERVTASWRGYRHLSGLKVRGQRTRTSGRKGGAVGVAKGGMAAPAKKSSSDAPAAAAAPTTDAPAAEAAPAEAAPAAEEKKE
The following text describes a protein:
Function:
GTPase, binds and hydrolyzes GTP (By similarity). Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis (By similarity). Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) (By similarity). Plays a dual role as both a protectase and a reactivase for MMUT (By similarity). Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl) (By similarity). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP (By similarity).
Subcellular Localization:
Mitochondrion. Cytoplasm.
Sequence:
MAMLLPHPHPDFLKGLLKAPFRCYRFIFHSSTHLGSGIPCAQPFNLLGLHYAKWMLLSDGLKRNLCVQTTLKDHKEGLSDKGQRFVDKLFTGLIQGQRACLAEAKTLVESTHSRKKELAQVLLQKVLLFQREQEQPNKGNPLAFRLGLSGPPGAGKSTFIEYSGKLLTERGHKLSVLAVGPSSCNSGGSLLGDKTRMTEFSRDMNAYIRPSPTRGNLGGVPRTTNEVILLCEGAGYDIILIETVGVGQSEFAVADTVDILFYYCHQLEEMNCRVSKEVYLRWQHGSNNYVCWRLDCASSKDTGRVCDALKLLRRRLAVWRPKVVRISARSWRGGHWNVGYDARILGPNTCQRGAACQTTKATESLDVEPHSGKRVRAFQESPHSPGADSCSGTKGPPWGPGPRASSRFVVEGF
The following text describes a protein:
Function:
Transcription activator involved in the spatiotemporal regulation of anthocyanin biosynthesis specifically in the inner pericarp of red-fleshed kiwifruits. Functions in association with MYB123 to activate the promoters of LDOX (ANS) and F3GT1 that encode the dedicated enzymes for anthocyanin biosynthesis.
Subcellular Localization:
Nucleus.
Sequence:
MAAPPSTRLQGMLQTAVQSVQWTYSLFWQLCPQQGILVWGDGYYNGAIKTRKTVLPIEVSAEEASLQRSQQLRELYDSLSAGESNQQTRRPCAALSPEDLTESEWFYLMCVSFSFPPGVGLPGKAYAKRQHVWLTGANEVDSKVFSRAILAKSARVQTVVCIPLLDGVVELGNTERVQEDIGFIHQVKSFFIDHHPPPPPKPALSEHSTSNLATSSVHPRFHSPPLPLTYAPLDPPLIANQIHMEEEQEQEQEEDEDDDDDDDDEEEAESDSEAHTGLNSEAQNPRVDHVARAAAEPSELMQLEMSEDIRLGSPDDGSNNMDPDFQLMVASQGGNPADQQQRVDSFRAESTRRWPLLQDPLGRSLQAPTSGGTGLEELTQDDTHYSQTVSTILQHQSNRWLESSSSSAAGCLMYSSQSSFSKWPLRPSDHHHQADATSQCLLKYILFTVPFLHSKYRDDNNSPKSATAADSASRFRKPTPQDELSANHVLAERRRREKLNERFIILRSLVPFVTKMDKASILGDTIEYVKQLRKNIQDLEARARQIEIDQRSRSSGDPQRSGAKAATDKRKLRIVEASGGAKGKAVDSVAVATPPPPAPPQPVAGVGVQVQVSIIESDALVELQCTHREGLLLDVMVVLRDHRVEVTAVQSSLTNGVFVAELRAKVKENVNGKKPSIVEVKRAIHQIIP
The following text describes a protein:
Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
Subcellular Localization:
Nucleus.
Sequence:
MASSDLDHLKISYRTRFCCTSRLPVTDLWQGQNLLENIQDCFEEKSYDTGFSTNPGSPTLCSTPCKLRNDSYSSPNKECQISPSKTDCVSSVKKKAKTSVLSHQTIMLQSQGNNSVLPPEIPQKLSQADLVDLKNTPNLKYASSGAEEFNKIPNEVVEEFYLTVGSPGLLAKETEILPLPKQATPTAHDRWNHKFGNSVNQQPSLPTSSLKTKKSLNYEDITVWSAVKTAEKDIKLSERRQKRIQSESEKGSQDTKQKIQQRAKTNFSTLLLEAAKGNCRNSSVHRHVSPPQTYSPSPLPNDLESSNDEFIIDESDCSASQSWILIPNKNSKSVKPGKTDPVKSSQDSERKKSGTEQQQGEKCSSSSDKHLNTEKEISNIVSEERTSKSIKHKARAVEKSQPSKRKKLDSLSNEMGSTSKSTRHKIYSEKSEQFLENKGAIVEHQSEKCETQIDNRESVEGLFNCAENQDSFHSEQNIAEVHTTLRTTKSKTASVEKSQTIEISKLRKCQKKDYKPQVSVKHHGTEQTKKKRSNMSQRNQDKLHRESDRILGQQKERAESCHSAEQILSADVSGKQKKNNSASQQVQKKGHLKKTSNKNEQMPKKRESLLKQNKSQDFTVTRSQRISKRPSTWWVVTTEQSNMSSSPTLELPVNHKKASRPSKETKKISVKTLGKGTIPLKRQKSSINAKSKAASIPNKRKGRRLSYSSDENCDMVHMIPNIDEQEGSLKETPKVACSSTAEPSEECIGAAQNVNLTPTILTGDSKISVTSAMEESGPTRLRNNVLTSRFNKISGDEQECGTNTNLPVRRTTRIKIKPLEYWRGERFDYENMLLDGFTVSGTISNDRVSPKQKSNRKRERVNTDSCEDEQKKKAIASLDISLGDPSKPTCVFDPGREQMVFKELVKIKGTHEFCVQDDTLKMFKILNTSMFATGTLILEPFKEKGKQYVCSDTVVFFVVSGNLLCTLHETNYNLNSGDTFYVPSGNFYNIKNLIDERSILLFTQIKTERPEK
The following text describes a protein:
Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Sequence:
MSRHLYARHKLGDGLQTPIFQVTRGTQSRRSRLKRSDGSTTSTSFILRQGSADSYTSRPSDSDVSLEEDREGVRQEREQQAAIQLERAKAKAVAFAVKTNVSYCGALDEDVPVAGTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLKLENIRIQQEQKRGRFHGKSSGNSSSSLGEMVSGTFRNTPPSAAKQKQKVAEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWRATHVPNSTPMNPLLGRNLGSTALSPYPTAISGLQGQRMRHGNHSGEHSPIERRSLMTSDENYHSERARKSRNRLSSGSQHSRDHYPLVEEEYSDPYQDTYKPHRNRGSPGGYSHDSRHRL