lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
Sequence:
MTDKAFTEHQFWSTQPVRQPGAPDADKVGFIMESSLDAVPAEPYSLPSTFEWWSPDVANPEDLRGVHELLRDNYVEDSESMFRFNYSEEFLRWALMPPGYHQSWHVGVRLKSNKSVLGFVAGVPITMRLGTPKMVLEKREHGEDGGEEVINDYLEPQTICEINFLCVHKKLRQRRLGPILIKEVTRRVNLMNIWHAVYTSGTLLPTPFAKGHYFHRSLNSQKLVDVKFSGIPPHYKRFQNPVAVMERLYRLPDKTKTRGLRLMEPADVPQVTQLLLKRLASFDVAPVFNEEEVAHYFLPREGVVFSYVVESPVGPGKDEENAGKASKGTPTGTKCVTGGCEKVITDFFSFYSLPSTIIGNSNHSLLKVAYVYYTAATSVSITQLVNDLLIIVKLNGFDVCNVVDIYDNGTYLKELKFSPGDGNLYYYFYNWSYPSIPANEVGLVMV
The following text describes a protein:
Function:
Endo-beta-galactosidase capable of releasing both the blood group A trisaccharide (A-Tri; GalNAcalpha1-->3(Fucalpha1-->2)Gal) and B trisaccharide (B-Tri; Galalpha1-->3(Fucalpha1-->2)Gal) glycotopes from blood group A- and B-containing glycoconjugates, respectively.
Subcellular Localization:
Secreted.
Sequence:
MGGVTMKNNLKKYIKYILSVILVFFVGVNGMEVYALEESRDVYLSDLDWLNATHGDDTKSKIVQKNHPFTPGNNNQSTKISLKMEDGSISEFEKGLGTIAGSPSTITYDISGAGVTKFFSYLGIDRSANPINEQYAKVDKIEVVVDGKVIYSTINQFPNGLTYETPAIKVDLNIPENAKRLQLKSYAGEKTWGDEVVYADAKFTAKGDFVNPNDWTPAEKRREISNEKPLLMIPLYANGSKYEKGDYAFWGDDTLVGKWKEVPDDLKPYTVIQLHPDDLPKRDGVAADFYEHMLNEAQSYVNPKTNKNEPIPIVLTVYTAGNVPGYTAAHWLTTEWIEDMYSKYSALQGVFSTENYWVWTDNVESNAAEYLKLSAKYGGYFIWSEQNNGGSIEKAFGSNGKTVFKEAVEKYWENFIFMYKNTPQAEGNDAPTSSYMTGLWLTDYAYQWGGLMDTWKWYETGKWKLFESGNIGKTQGNRQWLTEPEALLGIEAMNIYLNGGCVYNFEHPAYTYGVRNEESPLFSNVIKEFFRYVINNPSPSKNEMRAKTKSLLYGNFTQNGNGNYFVGLNTEMSQSPAYTTGRYGNIPAVPSSIERNKIESRLSGSQIKLIDMNSSELSNITNRKEYFNKLYKEEYNGNIFAQKLDNRWFIYNYKYNENINQKGSFDIANIKSEVTLEPHTYLIMEDNNQSINIKLNNYRTNKDSLWEGAKNADEAKKLPEMSKVDALNWVYDSYIKNTNNGEKRTSVIKLMNIDKAPTITNVNGIEGSYDIPTVKYNSETRSAEITIKNNGNIDFDIVIK
The following text describes a protein:
Function:
Catalyzes the export of L-threonine and L-serine from the cell to the extracellular environment (By similarity). Export is dependent on the proton motive force (By similarity). Required for in vitro growth and survival of bacteria inside macrophages. Increased expression is associated with low-level amikacin (AMK) resistance.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDQDRSDNTALRRGLRIALRGRRDPLPVAGRRSRTSGGIDDLHTRKVLDLTIRLAEVMLSSGSGTADVVATAQDVAQAYQLTDCVVDITVTTIIVSALATTDTPPVTIMRSVRTRSTDYSRLAELDRLVQRITSGGVAVDQAHEAMDELTERPHPYPRWLATAGAAGFALGVAMLLGGTWLTCVLAAVTSGVIDRLGRLLNRIGTPLFFQRVFGAGIATLVAVAAYLIAGQDPTALVATGIVVLLSGMTLVGSMQDAVTGYMLTALARLGDALFLTAGIVVGILISLRGVTNAGIQIELHVDATTTLATPGMPLPILVAVSGAALSGVCLTIASYAPLRSVATAGLSAGLAELVLIGLGAAGFGRVVATWTAAIGVGFLATLISIRRQAPALVTATAGIMPMLPGLAVFRAVFAFAVNDTPDGGLTQLLEAAATALALGSGVVLGEFLASPLRYGAGRIGDLFRIEGPPGLRRAVGRVVRLQPAKSQQPTGTGGQRWRSVALEPTTADDVDAGYRGDWPATCTSATEVR
The following text describes a protein:
Function:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Sequence:
MTDVEPVVSDFAATGRTGRRNALPDILGSTAGPGAADLPDKLAELTVGDDGEQGGESSSSTDPPKESTEGAKTEGS
The following text describes a protein:
Function:
Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLPARLACGLLCGLRRGPAPAAACYGPARWLLEGKCEVPIRQRASSLGRRVPPSSTATEDYAEGPDTEERFLFPEYVPERTPEEQVRELQELRELQQLQQEKERERLQQREERLQQKLRAGFRTLPVPEFPDASVPPSGIYCSGCGAELHCQHPGLPGYLPEEKFRDAAQAEGGPARTVCQRCWLLVHHGRALRLQVSRDQYLELVSAALRRPGPALVLYMVNLLDLPDALLPDLPKLVGPKQLIVLGNKVDLLPQDAPGYLKRLRKRLWDDCIRAGLVVAPGHQGPQYPAGDEPLEEIKNQNPSSRSRTVVKDVRLISAKTGYGVEEMISALQRSWRYRGDVYLVGTTNAGKSTLFNTLLESDYCTAKGSEAIDRATISPWPGTTLNLLKFPICNPTPYRMFKRQRRLQEDATKAEEDLSEEEQSQLNQLKKHGYIVGRVGRTFSYSREQDEVPFEFDADSLAFDMGSEPVVSVCKSTKQIELTPEDVKDAHWFYDTPGITKESCILNLLTEKEINTVLPTHSIIPRTFVLKPGMVLFLGGIARIDFLQGNQSAWFTVVASNFLPVHITSLDKADALYEKHAGHELLLVPMGGKERMAQFPPLVAEDITLKGGGKFEAVADIKFSSAGWVAVTPYSEGTLHLRGHTPEGTALTVHPPVLPYIVNVKGQRMKKSVAYKTKKPPSLVHNLKKHR
The following text describes a protein:
Function:
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAPKGGNQDKEEIWPYKITIGICAMHRKATSKPMRAIMKKLIECYGQWVDFFIFPEQVILNEPIENWPLCHCLVSFHSTEFPLEKAIAYVKLRKPYVINNLDRQYDLHPRHGYVIRGRPNEPDTELVEHPDHIEVNGEVFNKPFVEKPISSEDHNVYIYYPSSVGGGSQRLFRKVFLTETSCHKINNRSSWYSPKSEVRKEGSYIYEEFIPADGTDVKVYAVGPFYAHAEARKAPGLDGKVERDSDGKEVRYPVILSNKEKQIAKKIVLAFGQTVCGFDLLRANGKSYVCDVNGFSFVKTSTKYYEDTAKILGNQIVRHYAKTKNWRLPPDMPQPPILDLGLGDDPPMITTPSGKLAELRCVVAVIRHGDRTPKQKMKLVVTDERFFALFEKYDGYKKNEIKMKKPNQLMEVLELARALVSEKQKQGRKQLLEKRAKGSYLALKVGGQEIFRSFFVARVCILPSRCTTLNVTLRTAVVLAFMYAIGLNQMEIEQERHNLITSMRETTDSEDIHKTEHDLEMCEEDVKRWEQMRTVLEMYGHFSGINRKVQMKYLKERETKTSDEELKRDGAALLLILKWGGELTTAGKGFKTFNRLNGPSNVPGNMQAEALGRLFRTLYPGIRRTDGKSSPEDTQGLGFLRLHSTYRHDLKIYASDEGRVQTTAAAFAKGLLALEGELTPILMQVLSTVDYCVSLNFQFFQMVKSANTDGLLDDDCQARLYQTELKRYLHKALQADRDFTPQDYLELNPNGLRSIAAAMEFIKNPRKMCQEIAGYVEKMCGVIEEYSQTKPSGSTLYLQESMDLAQRRWNKELREFRRKNKHGEVEFDISKIPDIYDNIKYDMEHNPDLCINNEVEFERMYLCVKNMADIVVPQEYGIKTENKMVIAQRVCTPLLRKIRNDLHRCLENKESEETQTRLDPRASQGIATPFRHVRTRLYFTSESHIHTLMNLIRYGNLCSVDDKKWQRAMNFLSGVTEFNYMTQVVLMVYEDSRKEKDENDTAPRFHIEILFSPGLYPCFLTEKERIYESRFNLSTNPKPATSSKSSRESRDTNDSASSSTEGRRPSTEKLVTVVTPTQLSTPQVTNDDLSISSNAESTAAESTGLLNTTGKSHNDSEDDLNDVESVNLVALDELNSTAKTLTEDGKTAKRQRSVTGAEKSMEEGDKPHGEWKGNQVAKSGSQVSVGSNEMESNNESMETVGAGKGQWVKDLLDQTKRAMAMNSIREVEPSPPTQVVEEESTSATERQSRCQRGSFHVIEPPQIEEKSRRYFPYRFKHHTAQLLTDLGMNGGGVHMQNRLISTDVLTGKFGDHDNKKNPRKDLDFGAGTAVLSTAVIARSSSAPRLMTYESDDFSVGEIKRFWPPLRSLETLHDSINLSQFDGFLERLIKGALTPLPSPPKTPLPTALSCDAINKTPTQDEVEQVIGKLAPTSSTD
The following text describes a protein:
Function:
Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPVSMAVCETANVVNAALRESLGGNSSAAGSSADQAKSGEESNGSLQNHIVANAKRILMAKIEYEEVPNYHESVLESLKSKYIVIKPGNPGAINGFGGKNNTGKVVGANGHDNNGARKQAEHPNNQSHHNNHNNHPHPTSNPNELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLENCNVAESGGGCIVCAMAKTLLATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADTLEDAFEGHFSRERLEDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMIGNKLTKQISFKPRIDLSKYAARSPAAQAQPLTYRLVSMVTHLGVSQHCGHYTAIGSTDTGSYYNFDDSYVRPIAMQSVCNTNAYIMFYELDLSQTASPAANRPNGMRLTNGHSTTPVPATTVSSPSPTRFIGPQLPPGGVNGYSNGNAQKTAIQFKQHHQQSQQNGFQLGTGKFQDTAKPPLVGAHAKGEANPAPTANGNKSSSTSSNNSSSSNHKSINQQQYLPISSEDEDSEDERTSRPSTVQLPSMPKMTDDHTEKPKSPVKIQAKTPIKTPLKSLVPYESASEEEEAPLPNPRKRRSGEDSSESDQESGQTNGHSKTNGSLTNGSASSSVHVNNSKLKTDAIDEIFKSLKKSADSDDDDDEEESSIQLTNGWHPQKQSQSQSKAPPSPKTPPSPAVIKSKTGIWKVTRNDEVDDIDDDDDEEEEATVKIQTPSKTHRNPFSSSKPSTDSPATPGAKRQKLLNGSPVKSHQQPRVGNGYQSEATSNGSTINELLKQSHRGYGSSVLSWNGKPAELEKETFELVCAKRIAGHGSVDGSDIVESSVAVNASSGSDSNDVVVIAVALLVDAREQRQRDLDDDEENEMDRGRQRKVKSGSAKGNNASNSTPGYNPFQEYEGQKRWNKNGGGGGGFPRFYNQNFRQNFQQRNKFKFNRFGGPGGAKFQQQRALQRHLAAGGGFSRRQPSAQQQQQQS
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).
Sequence:
MHGAWKILSWAAGKGDEEEASKFSSGSDFTSPVKNSWIPGVGPDEEEFVNTPGQVEDEEMPGSPTSSKSSSASGHGRSDPSSSWADADIENSSQSSLVSLGEEPEDPLAQRFRKFLSDAEAAVTPPSPSYGPERVRGFEKTRLRKRGSAPSAGLKQSQMEKLEKLIPLDKVWDHLYPNVVEEQFSWPWVDLTEQQLALGKLEFKKFMVTLSCLGDLGLLPEKVLTLEQIKKLERLSLEDIPGYVSREVAINKGVRNEAFPYIRKDWLAKGLFSFECNVDKHGVCKFKCVKPRSTSTLLHRIFGDDRVMPVYFNEFPTEDKFQLVRDGILVGLRRYRLWSFKDSGKGDFRNRTKPYAKDYQRAVKCFFVCTESLADVDLSDPNFKYFTRIEAARCHIMHIHAMPTMPRFASRLQLALSKSVTANLNWDEIEVKQIPDILSKTLDNSGKFMAHTEGTSEISPDVARLLPCSVCKGRVGEPKGYPTLVQGCLFWKGMAIKGTWQVNHQLKGLQILYRPSMVKVTSDPILKDIPTIKSFEVVNTNTCYKLEEARLSQDLIILLSINNVPASFFLELVEKALEKLRTFFTERGQVFRELKSCSPDYAVGDQTLRMIMANIPMSNPQMQNNLKKITQDKIALLRKGCLPLPQSYYLMGTSDPTKEKVLKPNEVAIVKNGEKVIGKVLVYKNPGKHWGDVHIFDAVWDERLNPYVGPTKHAIFFSVRGNRPVVDEIANSDLCGDLFWVCSNAQLISLFTPSLPWKRIGEKINYPIGDGPSNLTSRALEYTLFDKFLKSRFTPYKPMSQAGIFWTAHMDRYLSLKDADEYSDELELISESLEELIDIFYRALDADKTGEELCLHRHTFAWMSVKLPRRLEPDCFPHFLKEIQTNRTYYTSTSILGQIYDMVVRNVDGIGCKPEETIAYDPKFEYGRFDRYMERWRGLLQQYNKDIKAAIKNHEEDRVIAYYQEILQGTNKSITQMWEEASALYAVNHEHAVMTLRKGHLPSLHCALTVALEYLCGIYASNEERKPYTLSASAKEDIFGPINFES
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
Subcellular Localization:
Mitochondrion.
Sequence:
MPATTTLLARAGSQLSSRGSIALRGALPASRCPEFAAYVARRPSDGAVLTPSTDAAPQRWLPSPATMPPSVSRDDARSPGRTCTRLTQLRHSLPLAHGHQHARPLPRAMTAGNIGTWQKKAGDSIAPGDVLVEIETDKAQMDFEFQEDGTLAKVLRDSGEKDVAVGSVMVKLEQEEDDTRANTSQPIAVMVEEGEDVSAFESFTIEDAGGDKTPATPSKKGEASEASEPADSGSKTAPPAKEESAPASIESDSTGDRLQTALQRQPSVSPAVKKLALEKGVPIGSIKGTGKGGQITKEDIEKYKPTGGAPATGGASAAASYEDTEATSMRKVIASRLTESMQQNPHYFVASSISVSKLLKLREALNASADGKYKLSVNDLLVKALGVAARKVPAANSSWREDGGKVIIRQHNVVDVSVAVSTPIGLMTPIVKNVNGLGLQSISSQIKDLGKRARDGKLKPEEYQGGTITISNMGMNSAVERFTAVINPPQACIVAIGTTKKVAVPGEPSEDGSSSIEWDDQIVITGSFDHKVVDGAVGGEFMKELKKAIENPLELLL
The following text describes a protein:
Function:
Promotes cell proliferation. Plays a role in tooth germ growth. Plays a role in the control of enamel mineralization. Binds the AMBN promoter.
Subcellular Localization:
Nucleus.
Sequence:
MAHPYEPWFRPAPPSGSAEDMSVPSWWDLHAGAGSWMDLQGAPGGLQGAGQGGAMGLQTLGPYTSDPQLCGPPPSHLGPPSPHLFSQDGFKPMETAGQEQQQHPLDEPMESSSRPKSQRRSAPRGSGQAVCRCPNCVDAERLGPCGDGSKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFTCSICNRVFMRNDHLAKHMRTHEPPREEEEAGAAVAGEAPLKPKREPESSCPGGSGQPN
The following text describes a protein:
Function:
Mediates zinc uptake. May also transport other divalent cations (Probable). Contributes to zinc acquisition during infection and plays a role in the ability of S.typhimurium to colonize the host tissues.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSVPLILTLLAGAATFIGAFLGVLGQKPSNRVLAFSLGFAAGIMLLISLMEMLPAALDTEGMSPVLGYGMFIIGLLGYFGLDRLLPHAHPQDLVQKRQQPLPGSIKRTAILLTLGISLHNFPEGIATFVTASSNLELGFGIALAVALHNIPEGLAVAGPVYAATGSKRTAIFWAGISGMAEILGGVLAWLILGSLVSPIVMAAIMAAVAGIMVALSVDELMPLAKEIDPNNNPSYGVLCGMSIMGLSLVILQTIGIG
The following text describes a protein:
Function:
Antimicrobial peptide.
Subcellular Localization:
Secreted.
Sequence:
MFTLKKSMLLLLFLGTISLTLCEEERDANEEEENGGEVKEEEKRFIGPLISALASLFKG
The following text describes a protein:
Function:
Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
Subcellular Localization:
Secreted.
Sequence:
AGSSFLSPAYKNIQQQKNTRKPAARLHRRGTESFWDTDETEGEDDNNSVDIKFNVPFEIGVKITE
The following text describes a protein:
Function:
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
Sequence:
MYVVLEGVDGAGKSTQVELLKDRFKNALFTKEPGGTRMGESLRRIALNENISELARAFLFLSDRAEHTESVIKPALKEKKLIISDRSLISGMAYSQFSSLELNLLATQSVLPAKIILLLIDKEGLKQRLSLKSLDKIENQGIEKLLHIQQKLKTHAYALQEKFGCEVLELDAKESVKNLHEKIAAFIKCAV
The following text describes a protein:
Function:
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
Subcellular Localization:
Nucleus.
Sequence:
MAFPYQCLVARSESSADGAAWTLFGASGSKIVVQSSNGVASVWSRQAVQVLDPKDDDTQEPPGKRIKLSTPKEQKFNFSSLVLSNNGHYLVGVTGEDKCVRVFQIDAQSGLQQLSERCMSRRPSAITLTSDDSTILCADKFGDVYALPLLPSPEDEQVEAPAPALPLEEKDFTPSATVFTVHSGRNRRTLEEQLKQKAKGPAKPKEAITFRHDLLLGHVSMLTDLAFAKIGNKSYIITADRDEHIRISRGVPQAHIIEGFCFGHEEFVSRLCVTRSGLLVSGGGDAHLLVWDWRNFLLNEKLPLRDTVIKHLRSRPDLSSSFKDDASFKTAVSGIWEVPGIKETSEVLVACEGLPGLFNFNVGTGAVNGDSLSLMGNPLDVAFVQTSPNSWTTIVSIDNVHKAGSTSELRENADGARLQYFSKQVDGAWREDAEMGALVSSFALGGTDGPDLTTADDKAVRDILYHVENLRKRPGAED
The following text describes a protein:
Function:
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MAVESGDPRSARIRWRVASAAAVAAAALLLGISGLMKALPNACVMTYMYPTYVPVPSGPGSPSGKYGLFLYHEGWKKIDFEQHLRRLAGVPVLFIPGNGGSYKQVRSLGAESDRAYNAGPQDKTYYQQSFFTPDEAGMSNDENLWGRESWDSPDHYVNRLDWFAVDLEGEHSALDGRILEEHTEYVVQAIHRVTRCQFFFDILDQYRESLRARSGGKRGNEDALPTSVIVVGHSMGGFVARAAVVHPELRKGTVQTVVTISSPHLLPPLALQPSLGHFFSRINKAWRMGYSSPRSRSGRPRPSSEAPLSDVIVISLPGGIYDYQVRSRMASLDTIVPATNSLTVGAPEMLNAWLSTEHQTILWCNQLVVQLAHTLLNVVDRQTGQAISSPRTRLAVFIARLRSAIPQTFGWLATADLMDDKESASGRNGDRDFHVDTSLVTVLAMDGRRRWLDIQKQAVHGRSNFVLVTNFAPCLGIRVHLWHGKSKKANDNAVEVTAKMVQLPSAPAPRQAEPGGQSEQASPSGILRLSADDLEGFRYITISVAPRPTVVGRPPPAASMAVGQFIDPRDGSAFLSAWSIFSSTYRSQSLHLNEKHPLVMNFSVSVGFGVLPLLMEVKTASCGISDRQQAGDSEVASKTRSSVLKQLTDLCKLRCFPPLAMLWDPYAGLQILPNLRVETIVSDSSTVLPGLKYGPHEASMVLLADPHCGYNITFKLAKSITVNRFLLTHASQIGGFMVVVLLYALSRQARAWELDTSFPSLYACLERNFMFPVPFLPLCFGPLFIYFFRTTIGGDIPPPYVQTSVMVRKVRAVPRLTTGIVATVLVFFVHPVLGLSVLLLAHTWSCHVALCRYVHLRVATADRPQADANSRRNGHHNGAKDDLDESSVVDTKSAALVHLESFKFFQGLLLLHFTATAMLLPSFIAWIQRPKVDRTLPWFLDSLLCFGVLLHGLYASSGGADTLSSFSRFEALRSYGLSVVFAVSGLYTYWAGLCLAPYRAFYAFAAIGLITSVMRYTDKNKGDCCSLYKSKRRHFHGH
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAAFTISKKRKFVADGVFYAELNEFFTRELSEEGYSGCEVRVTPSRSEIIIRATHTQDVLGEKGRRIRELTALVQKRFKFAENTVELYAEKVQNRGLCAVAQCESLRYKLLAGLAVRRAAYGVLRYVMEAGAKGCEVVISGKLRAARAKSMKFADGFMIHSGQPAVDFIDSATRHVLLRQGVLGVKVKIMLPEPKTRQKKSLPDIVVVLDPKEEEPITKPYTVINQPVEAAAAAGQEVVAEQETAVAY
The following text describes a protein:
Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Domain:
The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition; The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
Sequence:
MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGTPSFSLPPTEPSSEVPEQPPAQALPGSTPKRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
The following text describes a protein:
Function:
This splice variant of HMSD is the precursor of the histocompatibility antigen ACC-6. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. However, associated with GVHD, a favorable graft-versus-leukemia (GVL) can be induced by donor-recipient disparities in mHags. ACC-6 is presented to the cell surface by MHC HLA-B*4403. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. Immunogenicity of most autosomal mHags results from single-nucleotide polymorphisms that cause amino-acid substitutions within epitopes, leading to the differential recognition of peptides between donor and recipient.
Sequence:
MEIFIEVFSHFLLQLTELTLNMCLELPTGSLEKSLMISSQVLQIPVANSTKQR
The following text describes a protein:
Function:
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
Sequence:
MATKDRITCHILDTSLGQPARSVRVKLELLSASSTSSQTPSKTFESITDEDGRIKTWLPYSSALSSGEVPVYTLEDVFVNDIKGPSRWMLRFDTAGYFGGEDKTFFPEVTVVFRVEEGQTYHVPLLLAPYSYSTYRGS
The following text describes a protein:
Function:
Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.
Subcellular Localization:
Nucleus.
Sequence:
MSKREAFLQATAKDSVEDFLSFIQLHKDVSDPFDLNELLQELSRKQKEELWEKLKTLLTEALVANPVERWQNIDDDSDDDMEVESSSDVKQTMCVIHGVTIAAAASLCVIDEDVCYETLLECAAILSGIVHALPKSESHITLAIRHLCEAWWEKGLQGKEEFGKTAFLLLLAKSLEVKCVVADIGRLWHLHQTLLSFDFNSEESHNVKDLLLQCFLSINHIKKEEGRRFLSFLFSWDVNFIKMIHGTIKNQLQCLPKSLMTHIADIYFRAWKKASGDVLQTIEQSCIQDFMHHGVHLPRNSPLHPKVREVLSYFHQQKLRQGVEEMLYNLYQPIIWRGLKARNSEVRSNAALLFVEAFPIRDPNLNHEDMDNEIQKQFEELFNLLEDPQPLVRSTGVLGVCKITAKYWEMIPPAILTDLLRKILGDLAADVSSADVRCSVFKCLPILLDNKLSHPLLENMLPALKFCLHDNSEKVRVAFVDMLLKIKAVRAAKFWKICPMEQILARLEVDSRPVSRRIVNLLFNSFFPVNQQEEVWCERCVALIQMNPAAARKFYQYAYEHTAPTNIAKLMLTIRRCLNACINRTVPNEDTEDEDDDEGDGEGIVRGDSEKENKSVLENVLSTEDSASMASLLEIVVVLWRSIRKALDQNEEAKTYTISKFASVLPEYFKAFKEERCTVPLIILASFMPPAAVPTFSCSVLSKLRHLDSGADEQKYSTLIDCLCRWGQVGHVLELASEWLSESYPEKRGRKDSNRQVRIQDTMESKPALALDYIEYIMTHTMNRDCLLSLQTKKLNQLLKVLGLVKEVLFCYIKPSEAVTHNVNQDTALRAFSLYCRLSIHLQHKFSSEGRTYLSVLEDTGGWIESQVLPTLESNQDISEEPRNMCHQILKAYLTVCKDVLMVGLADSEFQAQLLQITLSVIQTEKCHNCLPMLFYVLKEITELCLAHKMSDASVECDEMLDAIQKAFHKSLETVARRLRKQREEALQLLQTIQLPLGEFVHTVQCWHTASKVLHRGTLSTLLAAVVVEISHSLRKITDLSELTPPSSISDLPPLSKCIMTIIVKSPSAVSSFLDELTECITLEEVEGILSLTAALYVAVVSSKRKQIPPAVKNTASAIYRKLKNFCEVTMDDAGSIERAVYESSMRILNEMLHPS
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates. May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells. Involved in iron homeostasis; affecting Fe-S cluster assembly and ceramide metabolism. Required for proper morphology and bioenergetic functions of mitochondria. Required for maintenance of neurons.
Subcellular Localization:
Mitochondrion.
Sequence:
MARADKLAEGLQKAGDSSQVTSTPSPLEPPSRRRRAVATSSTAPWQQALSTLPWTVAPGTSQTWAPAKPLQGCFIHSSSGFPLPGSGPSSGLTPRLAALHTHQAAALPGPSHCSSLPTRLLRELGVSHGTSLTHPLRMMIMMAPRRRMRTASPPAQMPRMSPISSDLWEPSRVRALIYGHHGDPAKVVELKNLELAAVGGSDVHVKMLAAPINPSDINMIQGNYGLLPKLPAVGGNEGVGQVVAVGGSVTGVKPGDWVIPANAGLGTWRTEAVFSEEALIGVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDWVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDLQELTDRLKSLGAEHVLTEEELRKHEMKNFFKDMPQPRLALNCVGGKSSTELLRHLAPGGTMVTYGGMAKQPVIASVSQLIFKDLKLRGFWLSQWKKDHSPAQFKELILTLCGLIGRGQLTAPACSEVPLQDYERALEASMQPFVSSKQILTMC
The following text describes a protein:
Function:
Plays a role in virion assembly by joining the head and the tail at the last step of morphogenesis. Six FII proteins probably bind protein W that closes the DNA-filled capsid, as well as the U tail terminator protein of the pre-assembled tail.
Subcellular Localization:
Virion. Host cytoplasm.
Sequence:
MADFDNLFDAAIARADETIRGYMGTSATITSGEQSGAVIRGVFDDPENISYAGQGVRVEGSSPSLFVRTDEVRQLRRGDTLTIGEENFWVDRVSPDDGGSCHLWLGRGVPPAVNRRR
The following text describes a protein:
Function:
Involved in spliceosome maturation and the first step of pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MAAPKEGGFKMSLGGLKGKVGLKAAPAKKDVKRPRLALGDDEEDDSGKQQEISGWDAAEGGAVDVGGPKEKEAPRVIPALPNRNWREDARRRQLAKAPHTKAQNTEVTEQMEQPQIQYGLTILKKEDQQDNAAEEEPAPAEPMEDVQDNLTEEQRLEKKALDALINGKPTDEGLVIPLHNDEDAFQSDLRSAPDAPTLDAYEATPIEGFGAALLRGMGWKDSDAAGKNGAPAKIKQVKPRPALLGIGAKEDAAAGVELGDFKGNRGKGKNKQQSYNPVALRNKKTGEVITEDELKAKLEQQDMVQEEPKRKREDERRSDKERDRRRGKDDYDDRRDRRKDKYRDEEYDKIETMIMTASGGGTGAEMRITTASGDETSDESVAAARATRSATGTAVDRETRSVIATGGIGVAIQNADENMTTTARRGGGDISVSINICIGIGMATAFR
The following text describes a protein:
Function:
Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGASKDETNAAATKAQGKPWDDDPDIGRWKMEKFDPSWNKGGMLEVSSFSTRFPRYEEKYLQEAWPTVQGALRDFGVTCELNLVKECITVSTTRKTRDPYIIIKARDLIVLLARGVPAPQAIKILDDEMTCDIIKIRNIIRNNETTHLQERFVRRRRRILGPNLSTRKAIEILTGCYILVQGGTVAAMGPSNGRGLKQVRRIVEDCMKNIKHPMYHIKDLLIKREQAKNATVANESWDRFPPNCAKTNAKQKKPYAAPSLPPQTPSKIDLELESEEYFLSDENKSAKERQEKLGKQSEKVHGNKRKREAALVPPKENTAGPSDSAISTNNGNVENPEMGMALQKKTKGFSNGEAQESCPRKH
The following text describes a protein:
Function:
Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin.
Miscellaneous:
MISCELLANEOUS: Part of the biosynthetic pathway for all classes of flavonoids, a large class of secondary plant metabolites, many of which are brightly colored.
Sequence:
MSSSNACASPSPFPAVTKLHVDSVTFVPSVKSPASSNPLFLGGAGVRGLDIQGKFVIFTVIGVYLEGNAVPSLSVKWKGKTTEELTESIPFFREIVTGAFEKFIKVTMKLPLTGQQYSEKVTENCVAIWKQLGLYTDCEAKAVEKFLEIFKEETFPPGSSILFALSPTGSLTVAFSKDDSIPETGIAVIENKLLAEAVLESIIGKNGVSPGTRLSVAERLSQLMMKNKDEKEVSDHSVEEKLAKEN