lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Replicates the viral genomic DNA. This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'-5' direction for proofreading purpose. The DNA synthesis very likely occurs by strand displacement.
Domain:
The C-terminus seems to increase the affinity of the DNA for the polymerase active site, and thus increase processivity and decrease the accessibility of the DNA to the exonuclease active site.
Sequence:
MKIAVVDKALNNTRYDKHFQLYGEEVDVFHMCNEKLSGRLLKKHITIGTPENPFDPNDYDFVILVGAEPFLYFAGKKGIGDYTGKRVEYNGYANWIASISPAQLHFKPEMKPVFDATVENIHDIINGREKIAKAGDYRPITDPDEAEEYIKMVYNMVIGPVAFDSETSALYCRDGYLLGVSISHQEYQGVYIDSDCLTEVAVYYLQKILDSENHTIVFHNLKFDMHFYKYHLGLTFDKAHKERRLHDTMLQHYVLDERRGTHGLKSLAMKYTDMGDYDFELDKFKDDYCKAHKIKKEDFTYDLIPFDIMWPYAAKDTDATIRLHNFFLPKIEKNEKLCSLYYDVLMPGCVFLQRVEDRGVPISIDRLKEAQYQLTHNLNKAREKLYTYPEVKQLEQDQNEAFNPNSVKQLRVLLFDYVGLTPTGKLTDTGADSTDAEALNELATQHPIAKTLLEIRKLTKLISTYVEKILLSIDADGCIRTGFHEHMTTSGRLSSSGKLNLQQLPRDESIIKGCVVAPPGYRVIAWDLTTAEVYYAAVLSGDRNMQQVFINMRNEPDKYPDFHSNIAHMVFKLQCEPRDVKKLFPALRQAAKAITFGILYGSGPAKVAHSVNEALLEQAAKTGEPFVECTVADAKEYIETYFGQFPQLKRWIDKCHDQIKNHGFIYSHFGRKRRLHNIHSEDRGVQGEEIRSGFNAIIQSASSDSLLLGAVDADNEIISLGLEQEMKIVMLVHDSVVAIVREDLIDQYNEILIRNIQKDRGISIPGCPIGIDSDSEAGGSRDYSCGKMKKQHPSIACIDDDEYTRYVKGVLLDAEFEYKKLAAMDKEHPDHSKYKDDKFIAVCKDLDNVKRILGA
The following text describes a protein:
Function:
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
Subcellular Localization:
Endomembrane system.
Sequence:
MAMAPPRKGENWELRQQLNSEYRDKRADAIKRVIANHTIGKDCSGLFPDVVKNMQTDDLEQKKLVYLYLMNYAKTQPELVILAVNTFVKDTADPNPLVRALAIRTMSILRAEKILDYLASPLSRCLKDENPYVRKTAALCVAKVFDLKPELAIEYGFIETLRDLIGDGNPMVVANAVAALGDIHEASLNLPSSQPGSPNDDESPSSVRPNQSLFIIDPATLTKLLVALNECSEWGRIAILTTLARYRTNDEKESEHICERVMPQFQHVNAAVVLGAVKVIMIHMKNVTKEDLLKSLTRKMAPPLVTLISSPPEVQWVALRNINLLLQKRPDILASEMRVFFCKYNDPSYVKVEKLEIMVRLANEKNVDTLLGELKEYASEVDVDFVRKAVRAVGQVAIKIDEAAGRCVEVLMELIETRVSYVVQEAVIVVKDIFRKYPHSYEGIIPALCANLEELDEXEAKASLIWLIGEYAEKIENADELLGAFLETFSEESYPVQLQTLTAIVKLFLKKPDESQAIVQKVLQAATKDCDSPDVRDRAYIYWRLLSSDPAAAKSVVLSVRPPISLPQTTVAPAILEELIGEISTLASVYHKPAATFIGKGRLGADEMHKKSLDAEDDVSREKALQAVVAGNQAENLLDFDDEPTPTNGESSIPAPGAGLGISSQAIASAAKSTNPLDELMDLFSTASMTTPVVQPGQPAAQAQTSAQSSGGLGGLNGLAGLSSPPQSVSPQPGAPQSQKQQQQAAAQDDLLGLF
The following text describes a protein:
Function:
Histone methyltransferase that specifically monomethylates 'Lys-27' of histone H3 (H3K27me1). Has much higher activity on nucleosomes containing H3.1 than H3.3. Involved in the formation of constitutive heterochromatin and the silencing of heterochromatic elements. Influences which sets of rRNA gene variants are expressed or silenced.
Miscellaneous:
MISCELLANEOUS: The binding to histone H3.2 is unaffected by mono-, di, or trimethylation at H3K9, but is strongly reduced by increasing levels of H3K4 methylation; MISCELLANEOUS: [Isoform 1]: Major isoform.
Subcellular Localization:
Nucleus. Plastid, chloroplast. Note=Never found in plastids and the nucleus within the same cell.
Sequence:
MATWNASSPAASPCSSRRRTKAPARRPSSESPPPRKMKSMAEIMAKSVPVVEQEEEEDEDSYSNVTCEKCGSGEGDDELLLCDKCDRGFHMKCLRPIVVRVPIGTWLCVDCSDQRPVRRLSQKKILHFFRIEKHTHQTDKLELSQEETRKRRRSCSLTVKKRRRKLLPLVPSEDPDQRLAQMGTLASALTALGIKYSDGLNYVPGMAPRSANQSKLEKGGMQVLCKEDLETLEQCQSMYRRGECPPLVVVFDPLEGYTVEADGPIKDLTFIAEYTGDVDYLKNREKDDCDSIMTLLLSEDPSKTLVICPDKFGNISRFINGINNHNPVAKKKQNCKCVRYSINGECRVLLVATRDISKGERLYYDYNGYEHEYPTHHFL
The following text describes a protein:
Function:
Attaches the virus to host cellular receptor, inducing endocytosis of the virion by using different host proteins including TFRC, GRM2 and ITGB1 (By similarity). In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity).
Miscellaneous:
MISCELLANEOUS: Arg-352 is highly involved in rabies virus pathogenicity. Its mutation dramatically attenuates the virus (By similarity).
Subcellular Localization:
Virion membrane; Single-pass type I membrane protein.
Sequence:
MVPQVLLFVPLLGFSLCFGKFPIYTIPDKLGPWSPIDIHHLSCPNNLVVEDEGCTNLSEFSYMELKVGYISAIKVNGFTCTGVVTEAETYTNFVGYVTTTFKRKHFRPTPDACRAAYNWKMAGDPRYEESLHNPYPDYHWLRTVRTTKESLIIISPSVTDLDPYDKSLHSRVFPGGKCSGITVSSTYCSTNHDYTIWMPENPRPRTPCDIFTNSRGKRASKGNKTCGFVDERGLYKSLKGACRLKLCGVLGLRLMDGTWVAMQTSDETKWCPPDQLVNLHDFRSDEIEHLVVEELVKKREECLDALESIMTTKSVSFRRLSHLRKLVPGFGKAYTIFNKTLMEADAHYKSVRTWNEIIPSKGCLKVGGRCHPHVNGVFFNGIILGPDGHVLIPEMQSSLLQQHMELLKSSVIPLMHPLADPSTVFKEGDEAEDFVEVHLPDVYKQISGVDLGLPNWGKYVLMTAGAMIGLVLIFSLMTWCRRANRPESKQRSFGGTGRNVSVTSQSGKVIPSWESYKSGGEIRL
The following text describes a protein:
Function:
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity). May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). May play a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Involved in phospholipid biosynthesis (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Vacuole. Note=Enriched at sites of lipid droplet (LD) biogenesis.
Sequence:
MIRQLNYWSRKAYLIYPFQVFVGALLSIVVSSETLNHQKETCALLKSSNIFNVIFAYKANQLWPFLFFSLAFLQIYFHYLARMDILPLPISSTETSSSYLTYTNHWPLLKNRIISIMITQYACKFVLKYLLLFLNFQFIDHVFIWTGGECSSGSKTTSAEKCRLENGKWDGGFDISGHFCFLVSISMILWMELHLFSRFVQAEDMFWVVNKWVRACLAIVCAVLVIWICILWVTAIYYHTILEKVLGCLMGFICPVFIYHILPKIGILHNYLYL
The following text describes a protein:
Function:
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).
Sequence:
MINFEAIIGIEVHVVLNTASKMFSKAPNRVDNQKINHFIDPIDLGLPGTLPQVNELAVYKALLLADALKMKTVTNKLVFDRKHYFYQDLPKGFQITQQNYPFAKNGVVTINVDAIEKPIYIDRFHLEEDTAKQHFNHDQILLDFNRCGAPLIEVVTLPVINTAKEAKAYLQKLRQILIVNNISNAKLEDGSMRSDCNVSVRLKGQRQLGTKIEIKNINSLNNVEKAIDLEINRQVKALINGETLSQATLSFDDKTNNNVFMRKKDNTIDYRYFIEPNIMTSNIDDLLLEKPVAFQLEQFQKELIDSNVNPQLVQLVVDDATIFSAFQTINSVIKNPQETIRWLCIELIGQLNKTNSSLTANLIQDLITLIEMLKAAKVNQKQAKQLITLMIETKKDPKSLAKLHNLEQITDPKELQKIIKKIFQENEKEILKNIDRIERIQKLIIGQVMHKTNNRANPQQVFIIVENMLHEVRERDS
The following text describes a protein:
Function:
Converts sphingomyelin to ceramide.
Subcellular Localization:
Secreted.
Sequence:
MLRELTAAVLLLLGCSLAAPATKVSNLETSCSTCEFAVRVIHNMWGSDTMDECAEEFIDSICETLQIEDHFVCSGIASAFAEEAVWVIGEILIEPEELCGLLIDGCGNFVNPLTQQWNLSIAPNKPSKAAAKPIDKTKPTLKVLHLSDLHIDRKYTVGLEAQCGEPQCCRPIEDPEEIFMQKPNTNNAGDKIVQPAGKWGTVADCDTPYWLFTNMLDHIAATHKDIDYVVVSGDLESHADWDYTRERHQEMVKNSSDTIRDRLNNLPTFFAVGNHEGVPIDSFAPHFTPEKFHMDWLYGTMADAWSGWVPEDQMDTVWYMGCYMRKMWPGLRVISLNNGYGDHVNFFLYVNQTDPDGSLSWFQNQLVEAEKAGDKVHVVAHIPGGSGEALEGWAINYYKVINRFEDTITAQFFGHTHSEEFNMFYENPDDASSRPTGVTWSAPSLTTYSEYFPAYRVYTIEGQYAGSQYRVIDWAEYYVNITEANANPTKDPEWKTLYASVLAEYEMDDASPAEWDKFITKMITDDKLFGRYRKNFYRQTDKGECDWSCRRGFLCSARKNHHFTPICDDLPLDPPSGGRRVSTLSSSSITRKSKRRKITPNLEAVPTKEEILARARKVVSKHQMKKNRADGKCIL
The following text describes a protein:
Function:
Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
Sequence:
MKKVPVKEAIGYVLCHDITQIIPGKIKDRAFKKGHIIREEDVPVLLSLGKDNIYIWEKKEGYLHENEAAERLKNLSAGDGLAFSEVKEGKINFIANRDGILKIDKELLMQLNLIDEVMLATRHNNMPVEKGEKVAGTRVIPLVIDEKKILEAEKLTKGKKIVSVKPYKKLKVGLIVTGNEVYYGRIKDAFSPVIEEKLSKFDCQIIDKVILSDNPKIITETIENYIDKGADLILCTGGMSVDPDDTTPTAIKNTGGEIISYGAPVLPGAMFLVAYKDDIPILGLPGCVMYAKTTIFDLVLPRVIAGERVTREELAAYGHGGFCAGCEVCRYPNCGFGKGW
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MGNVPAMPAHVFQTAQENHVVAVAEETFSLCDVGRLSQVIRKLHRSIEQHPHSKQADTTCCVSAERRSNDSYPSSDDGDVPEWRLHFSNRANPLPVTDKRQLHYRSHMYMETEGLECILPDHMAQLEDIVRHHTLAVGPGYEEELLQHLPHSTDALTSLFNELEIRLTSISPSECEDFPIRLKTYTELLCLIKGQLYDESRPFREFKIGYFAQFAKHPIEILVKIALLLSNMEWSVTEICPMMLAYEAVMDVVPLIQKLIPSESDDLLPEIKSNIWESFRKTVGSMGDPRDGAIHSVTCSLVDSVKSIHSHKELVQSFAPDDDCHSFGNLLSGVIGRWISALEKHPMSDSRRKNIFMLNNMSHLKGKTNGLLDDLLPQQHLDFAYPDYFKLLTDIWIQGYLVDAWKPALSCLSCKSWWVSRHSSLVKFTSTFNGIFDHQKTWVVPDPALRETLRVRIKGHILPTYRAFLVKYPDTGPSGCLCLWGDSAQEIYSAESLELVVDTIFEGGTGQPTSPSLSP
The following text describes a protein:
Function:
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.
Subcellular Localization:
Endoplasmic reticulum. Membrane; Multi-pass membrane protein.
Sequence:
MTKTATKEVSENGAGKVNSCRNFPSTIHKPAAQQLFICPEVSLKWGCAIIFILASACYVNSVNGSFVFDDTEAIVNNEDAKGKTPLNEIFFNDFWGTSLNHKSSHKSYRPLTILSFRLNYIFNGLDPRPFHLTNVLLHSICCTLSLVIFSTLLGETRPRLAFITAILFSVHPVHTEAVSGIVGRADLLCGIFYFLSIYWYAKHLDGGSLTSFATSMASCAIAMFCKEQGITVLGVVAVYDVTRSVTGTFNFGNVMKRRDILQRFFLIAVVGVALLYVRLSVMGSSGAPAFQRVDNPASFADSPTTRALSYNYVYSIHALLLLWPHWLCFDWSMGCIPLIGDGRHQQVMDPRNLGSLFFWIVMFSAIFKALFSPSQRQRKYLTLGLALMAVPFLPATNIFFRVGFVVAERVLFMPVAGYCLVLVYGAEKLNAFLFPFGHSKLWILRGCLLAVVVTFALKSFRRNMDWQDEGRLFLSGLAVCPLNAKVHYNIGKNAADRGLRDVAIDRYEKALELNPDYDQAMNNLANLLKDLGRLQSAEDWLVKAISVRPDFAAAWMNLGIVQALLRKHKEARVSYLTALSHRRKYPDCYYNLGNLYLELGQFREAEEAFRNATLLQPTHVLAWTNLIVMLDNTGQSQRSESTALEALAILPNEANLHFSLAGILGKRSQFKASELHFLSAIRLNPHSPIYHTNLGVLYHRWKKFQLAEQSYQRALSLDPQWKSATENLKLLQKAKQNQF
The following text describes a protein:
Function:
GDP-GTP exchange factor component of the mitotic exit network (MEN). Fine-tunes the timing of the mitotic exit and couples this event with cytokinesis. May also be involved in proprotein-processing in the secretory pathway (By similarity).
Subcellular Localization:
Cytoplasm. Bud.
Sequence:
MRAEGNDMAESGRAVFSAADYYPAPSGRVITYAAGGRGRQIMAADVTALVAALTSPVDGVEYELFADFFLVYRNFLEARRLLELLEARFDWSLGEIGAGRAKARVVGEITLVRTFVLLRHWVINYFAQDFLPDVALRERFLAFVNGLGGAAGGTRPKIVANIVVSLKKTWAYTVRLIWDDLDLEREFELRSADAWLQFQIPDVTQLKTEAGLQRDSRLSFYARQSSTNPSFRNESVLSLYRPKDNFQLPVRNNDYNIKQGTRIKKRTASMFLYPQDSLNAPSGNQKPQCSLEPPFPAHSHVRKISHISKVTNVSNVIKEVAYPTSPAVESFFPPTPSKKLEFTVNSTYVPPAAAECSREPSAQKKPRSPNGYRAVTGLLSKWRMNHLSRHKACDRTSTVEPAMDNLIKYVFSISSLESPKGDIQEEREISPSKFDILSARTIEEVEHLITVENEVLQKVTAHEGKVPITSSSAREARFPPLLNEAPLLDQAPLGNGQEYSVIDNLNLYRTVSTIATSVIKLTRTASQRQTKVTLPPPPPLRQRPTSLSAFRGSSSRMLLSDSLRRDGYQNSKASLHLRPLASADENAEGSSVQASNPPQVIFHTHALIKTPTDKVFDAKAVEDTSPKTSLVSTQVTDARPPSYESTITYDSDLQDITMRDYNTSNQTENHNDGTLDTNQPILNRKTNHSNLREFLFEASTSGSPAAHTTQEPTDESTGRLGACPTVMRSISEPIPTVMRSNNGDTHTKAKPEFNIQSHDDTFSRKPMRPSLLSPPINIRGSFDTLHRKNVPAPISVPPNPVTKNASVSPASGRISIIKKSGNRTSPTTRSPLLDTTSAFMEKTDSFAKQEASLNALENDLQAILITTGRRSSTFSKSGTDSTIATNVLLESIQTSPQKNTHLMTNISEDDSASNTDTKPMEFSSVGIESSASNSSSFADALCEPANRSSPSHNPYSGQCTTIEDRYRRSRFASQPDSLLGYINENGNKYIFSPGETAEDASPKKDMETLKTKFMTTKEPPVCPSGNDADLALIISKLKETNPSAERIETENPNDDANNLTPPATSSSNNENSSDPVAVALMKLEGTFAKPAKEDNTASKLNSPRSSVLAKEVEKLDFQKWRFPSSKTMNKRQSMFIERRRTMTDIFSSATEDTSSEEQSPKLSDREIRELLETYKLQDPRLNIKNVEHHVPFILMYDSCSIAKQMTLIEREVMNEIDWKDLLDLNMKKSLPRVTSWLQLLLHNEELSGIDLAIARFNLTVDWIISELVMTTDIKLRRNAIQRLIHVAEHCRMYQNYNTVMEIVLALNSVVVQKFTSSWRLIEPADMLTWEHLKSIPSLDRNYHNVRNLLNSIDPIKGCIPFLVVYLSDLALNSEKRDWIVPNEIVNYNKFQTNVQIVKNFIQRVQWARFYDIRADEDLLSKCVYISALSHEEIGYLTSF
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MQVSADGLLCCTISSDRSVKVYDVVNYDMMVMIRLPYVPGAVEWVYKQGDVKAKLAISDRNSSLVHIYDARAGSNEPIISREIHLGPVKVMRYNSAFDIVISGDEKGIIEYWSPATLQFPESEVNFRLKSDTNLFEIAKCKTTVSAIEVSPDGKQFSITSPDRRIRVFWFRTGKLRRVYDESLEVAQDLQRSDAPMYRLEAIDFGRRMAVEKEIEKTETAPQPNAVFDESSNFLIYATLLGIKIVNLHTNKVARILGKVESNDRFLRIALYQGDRSSKKVRKIPAAAANVNESKDPLTDPTLLCCAFKKHRIYLFSRREPEEPEDATKGRDVFNEKPPADELLAVSDIGKAVTTSLPDNVILHTTMGDIHMRLYPEECPKTVENFTTHCRNGYYDNLIFHRVIKGFMIQTGDPLGDGTGGQSIWGREFEDEFHKSLRHDRPFTVSMANAGPNTNGSQFFITTVATPWLDNKHTVFGRVVKGMDVVQGIEKVKTDKADKPYQDVKILNVTVPKS
The following text describes a protein:
Function:
Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces. The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules. The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase. Within the complex, binds microtubules but with a much lower affinity than SKA1 (By similarity). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MSVTGNFFSKLRSLALTLEKETAQLEQVFGNEDNEYEEESPMRVLHDLRSDIMVLKGDFQSTLDKKLTRGQELSAFIKACRVLHERSAADIEQIKETFQTYGYKPLCNDNSENEQTQESEKPKDNDVSPRKADAEDLPILEKAASTSWDLLRAPQLSDFGLSHYQLPTAWEPPKVKPCPKNPEEEKPRIMYKDPEPINVAKTPKCALRLEEDFSQIQHFGISDCSTNLNDDYTIALINKNFQKKQNDTENETCQAKNLKSLLATPSHLSHRMDCVDSPLPPVFFTPGLKVHKKETISLPGKTGERQGLNAADTDSTLLSGTCDRKDSDNAHLEDVHECTAMKPAMDLKSISAAPPYLSLGSNFDSVYSPRPPVFCTPGLKTHKKETSSVLVEPKEVTGCSDTPPLPSFQTNWLKNDTTEKALDITEPVPRPELSYRQYLEEPPSLVLNSNKYEAPAMTEYDIGTPTRPEMTVSLTEDLFKYNVKPSSPPKMSEYEKMLWTPIRPEMTSCITEDISQILSKYCDNNTNVADKEMWNKAGASFGKISSEYEDKENRQY
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA. The BPB1(SF1)-u2af59-u2af23 complex has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLNSRSVGSTGSNNTPLGRRRFDEKPDSLPPLPDANGMSNGYRDSYKSNSRMDHRPDGYHDGRGRRAYRKHYWGHPTPIEEMLPSQMELETAVKSCMTMEQLELYSLNVRLEEITQKLRTGDVVPHHRERSPSPPPQYDNHGRRLNTREIRYKKKLEDERHRIIERAMKMVPGFRAPSDYRRPAKTQEKVYVPVKDYPEINFIGLLIGPRGHTLKDMEAKSGAKIAIRGKGSVKEGKGRSDPSVRGNMEEDLHCLVTADSEDKINHAIKLIDNVIQTAASVPEGQNDLKRNQLRQLATLNGTLRDDENQVCQNCGNVGHRRFDCPERINHTMNIVCRHCGSIGHIARDCPVRDQQPPMADSTADREYQSLMQELGGGSAISNGNGEPQKSIEFSESGAASPQAGHPPPWAAASTSVSSSTSSPAPWAKPASSAAPSNPAPWQQPAAPQSAPALSMNPSSLPPWQQPTQQSAVQPSNLVPSQNAPFIPGTSAPLPPTTFAPPGVPLPPIPGAPGMPNLNMSQPPMVPPGMALPPGMPAPFPGYPAVPAMPGIPGATAPPGAPGSYNTSESSNLNAPPGVSMPNGYSNR
The following text describes a protein:
Function:
General activator of RNA polymerase III transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSSIVNKSGTRFAPKVRQRRAATGGTPTPKPRTPQLFIPESKEIEEDNSDNDKGVDENETAIVEKPSLVGERSLEGFTLTGTNGHDNEIGDEGPIDASTQNPKADVIEDNVTLKPAPLQTHRDQKVPRSSRLASLSKDNESRPSFKPSFLDSSSNSNGTARRLSTISNKLPKKIRLGSITENDMNLKTFKRHRVLGKPSSAKKPAGAHRISIVSKISPPTAMTDSLDRNEFSSETSTSREADENENYVISKVKDIPKKVRDGESAKYFIDEENFTMAELCKPNFPIGQISENFEKSKMAKKAKLEKRRHLRELRMRARQEFKPLHSLTKEEQEEEEEKRKEERDKLLNADIPESDRKAHTAIQLKLNPDGTMAIDEETMVVDRHKNASIENEYKEKVDENPFANLYNYGSYGRGSYTDPWTVEEMIKFYKALSMWGTDFNLISQLYPYRSRKQVKAKFVNEEKKRPILIELALRSKLPPNFDEYCCEIKKNIGTVADFNEKLIELQNEHKHHMKEIEEAKNTAKEEDQTAQRLNDANLNKKGSGGIMTNDLKVYRKTEVVLGTIDDLKRKKLKERNNDDNEDNEGSEEEPEIDQ
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Sequence:
MSDLSAQKRLAADVLDVGENRVWFDPDAQSEIADAITREDIRELVADGTIDAEDTQGNSRGRARERDAKESYGHKKGAGSRKGKAGARQNEKREYVAGIRAQRQQLRELRDDGTLSPAQYREMYNMANGGEFDSVRRLTNYVEENYGDS
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MIDRPPRDKEMPIWEHLAELGQRLKRVLIASLIVFLIMWLPAPLTGAGNPLTTVLFNVDLYRPFGYWLFYQSIEPIVTELNKTTRIQIVLIWGQVWNPLASVVYSSAYITALIVFPYFVYEMWKYIKPALYPHEERAVKKYLGGSLILFYLGNLFSIYVIFPAVFRFTANFATILGLSQIVDISSVVNTWITLALMSGVIFETPVVMAILSEICVLNPYSVQEYRPVVYAAALILIAVITPDPTVVSTILLFIPFILLFELGLVFSKRIFKRCPEFQRPR
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.
Subcellular Localization:
Cytoplasm.
Sequence:
MQAENGNKRETRLFRVSEENFDAVLDEAAEIIRRGGTVAFPTETVYGLGANGLDPEAVRKIFEAKERPPGNPLSLLVHSGEDVGKVAKNIPEKAFRLMDSFWPGPLTIVLEKKDIVPEITSGNLPSIGLRMPDHRIPLELVKRAGTPLAAPSANLSGKPSPSLAAHVLADLTGRIDAVIDGGGTAIGLESTVVDMTVEPPVVLRPGAVGIAELEKVIGKVRPTYGEPDSRAVPEKQAGQKYNHYTPDTQVVLVEGDRKKVSEKIGSLLENSLREGKKVGFLLSNETAGFFASEGLSAQECFLLGSRDEPEEAARRLFEGLRVLDAKSLDVILVDGSFSPSGLGAALLNRLREAASLRYAV
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTIYSIALISRGGNILTAIQNYKLKNFSSILAQFSRLEKGSQVTFIQLEKIKYIYQPVDDIYVVLITSINSNIVEDTQILQCIVSVLSQRLDGITEAKICSDVFVITDVISEFCNFDGTCEKLTSSDIEQNLVMQSQEEELYFLELKQKKSDAKKLAQQKASELSAEKKSREKLEKQKGKEQKAIDEKYQEIQRIQQEQMIKMQEEEEEKRRIEKQKKKETIKMKKGGITLGKQKKILFDEDEEKILNNEDDEDRSTNQQEEEEQKQQPIQEKKLMTENMIVKLIENVSCSMYSENSTCSLSLSGSLSVSVADASLTHTPITINQYELPLKTQLHPQMDTTAFSKDHILIPKANAKGYAIGPTPSLLIKWSYASTDNESLPISVTCWPSEEENHLSMTISYETKKQLNNLRIIVPVKENVIVDSCEGTYNMEDGLVWIIGNVENGSTGAMEFTLNDNNLRTDDMFPVKIDFDVDQTYSGMKINEIKLDNVDTSIQCTTDFKVFP
The following text describes a protein:
Function:
Hydrolyzes a wide range of dipeptides. Highest activity against Ala-Gln.
Sequence:
MACTTILVGKDASYDGSTIIARNEDSANGEFNPKRFIVVKPEEQPREYKSVISHLTITLPDDPLQYTAVPNADLKEGIWGEAGVNEANVAMSATETLTTNERVLGADPFVEYTPAKGDEPEVPGGIGEEDFLTIVLPYVKTAREGVQRLGALLEEFGTYEMNGVAFSDSNEIWWLETVGGHHWIAKRVPDEAYVTMPNQLGIDEFDLEDALGDQEAHMCSEDLAEFIETNHLDLAVENTTPFNPRDAFGSHSDSDHVYNTPRAWYMQRFLNPYDEVWDGPDADHKPTSDDIPWARQPERKVTIEDIKYVLSSHYQGTPFDPYGQLGDERTRHMYRTIGINRQSQLAVMQIRPYRPQASRAIQWMAYGSNPFNTLVPFFPNVDTTPAYLEDTTTRVTSENFYWANRIIAALCDGAFRSTSNAVERYQEKTGAMGHRLVAATDEQIARLGLTAAEEAAQSAAEEEFEADNVDGDVQPMTPDETIAALRNPEVREILAAANQTMADQLKEETEKLLDSVLYTRSMEMKNGFHMSDF
The following text describes a protein:
Function:
Catalytic component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Has a role in regulating heterochromatin propagation and euchromatic transcription. Also has a gene activating role.
Subcellular Localization:
Nucleus.
Sequence:
MPLGRSSWICCAKYFVNTKSRFNEILPPRFTLIVSFYSMNTSENDPDGHYDFPEMTEHHSDRASSYANANNVNSTQPQLVSSEQALLAILGGGLQSITPNSVNQNAYSRSTYRTDGGLNSQPVSSLNNQWGNYNPAFLPSRYDSSFHPYTISQAANQPFPQHLLGNSNAGVAQQSGMRTIGLPPTVGSSFPQQKSSTYENFFDANSPSSQQFPSTYPSRSQNPLSSSGDGSTAIHAGPIQHQNSNAFSNYPYPLDASHLSSQQLLSMYRDQVSHGVTPSTFRNHESFMPTQLVSATELSKSVDNAVLPIPPTTAPAVVSPPASSFPLMSSAATSGNISSPALFDSELGARPEGSVAIEPSRVLLQWSSQSSSHTIPSAGASIPTSSLKSFFEHAAEAARKCNLDPRALESFEQHMLSDRLHDPVVLFHYFQIRNSICWLWIKNPTHAISRVEAQGVCVDRCLFQLASLAYEFLVRYGYINYGCLSFDSSFTNETNTGTTSSSASKQKTIAVVGAGLTGLICARQLTGLFSQYSSSFLSKNELPPKVIILEAKERTGGRIYSRALPVSHTSATQINHHTSNSNSISSNSTSLNPKDVTDPSHIPSAIDLGFQFLFSPMDDILLNLLNKQLGIEVTEMTGSDLVYDETDTKVLDMVEVKKLNILWEKLLEYVSVCFFINVEESVRISWISQFQLFIDEMFPDHLSKSLSLNASHEFSFKKTMLILIDEVSSYAKLGNSQKKFLIWCFKVAELDDTLYPLNTVDTDFSKDILIPKVARRGLSQLPWALQSYPSPLNIHYEKFVSKVTIENDKCTLDCKDNSSYEVDQVVIACSPSHFSSNIEFSPGLPNFVTENIKSIDFKPGKKVILRYAAAFWRKNIRSFGIIPKSLSQEMNNDENDGKSCFVLRIWNMLPETGVPILVADINPQMTSSSSNETSHLIQELHSLIVDHFQNDSNSSADLLDAWVTNWSRNGVYDGLNSYPNFANDKQQYEKRFRQSQLSYNLGRLHIAGDYIFSCVGCRTLQRSFLSGLSVCTGIIDSLAPISLTIPIIGETSRKELDQFLRNSKVNNFDPNAEAQRHLSYQARYRLKKQERLDEHKEEQEQLVTELLGYLPEPPSKPNANPFLLYQKMQWHVCRALADEDKRRLTGDSTAKATINETRAKLGKTWRQLDDLGKKPWIDEIAAQREAYAGKILRYQRLTKEYEMRAEQIRNDYAAKCQDEPIPDDEARLFMQAQREEEQRKQTQDDNISKSREASDEEYHDDGSSDSGYNGTRY
The following text describes a protein:
Function:
Could facilitate a sensory photoresponse.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIHPEQVADMLRPTTSTTSSHVPGPVPTVVPTPTEYQTLGETGHRTLWVTFALMVLSSGIFALLSWNVPTSKRLFHVITTLITVVASLSYFAMATGHATTFNCDTAWDHHKHVPDTSHQVCRQVFWGRYVDWALTTPLLLLELCLLAGVDGAHTLMAIVADVIMVLCGLFAALGEGGNTAQKWGWYTIGCFSYLFVIWHVALHGSRTVTAKGRGVSRLFTGLAVFALLLWTAYPIIWGIAGGARRTNVDTEILIYTVLDLLAKPVFGFWLLLSHRAMPETNIDLPGYWSHGLATEGRIRIGEED
The following text describes a protein:
Function:
Phosphatase that acts as a positive regulator of brassinosteroid (BR) signaling. Dephosphorylates BES1, a transcription factor that regulates the expression of BR-response genes, thereby playing an important role in the regulation of response to BRs. Inactivates the negative regulator of BR signaling ASK7/BIN2 by dephosphorylation at 'Tyr-200'.
Subcellular Localization:
Nucleus.
Sequence:
MAPDQSYQYPSPSYESIQTFYDTDEDWPGPRCGHTLTAVFVNNSHQLILFGGSTTAVANHNSSLPEISLDGVTNSVHSFDVLTRKWTRLNPIGDVPSPRACHAAALYGTLILIQGGIGPSGPSDGDVYMLDMTNNKWIKFLVGGETPSPRYGHVMDIAAQRWLVIFSGNNGNEILDDTWALDTRGPFSWDRLNPSGNQPSGRMYASGSSREDGIFLLCGGIDHSGVTLGDTYGLKMDSDNVWTPVPAVAPSPRYQHTAVFGGSKLHVIGGILNRARLIDGEAVVAVLDTETGEWVDTNQPETSASGANRQNQYQLMRRCHHAAASFGSHLYVHGGIREDVLLDDLLVAETSQSSSPEPEEDNPDNYMLLDDYLMDEPKPLSSEPEASSFIMRSTSEIAMDRLAEAHNLPTIENAFYDSAIEGYVPLQHGAETVGNRGGLVRTASLDQSTQDLHKKVISTLLRPKTWTPPANRDFFLSYLEVKHLCDEVEKIFMNEPTLLQLKVPIKVFGDIHGQYGDLMRLFHEYGHPSVEGDITHIDYLFLGDYVDRGQHSLEIIMLLFALKIEYPKNIHLIRGNHESLAMNRIYGFLTECEERMGESYGFEAWLKINQVFDYLPLAALLEKKVLCVHGGIGRAVTIEEIENIERPAFPDTGSMVLKDILWSDPTMNDTVLGIVDNARGEGVVSFGPDIVKAFLERNGLEMILRAHECVIDGFERFADGRLITVFSATNYCGTAQNAGAILVIGRDMVIYPKLIHPHPPPISSSEEDYTDKAWMQELNIEMPPTPARGESSE