lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Unknown. May be an iron-siderophore receptor.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MNKKHGFPLTLTALAIATAFPAYAAQAGGATPDAAQTQSLKEITVRAAKVGRRSKEATGLGKIVKTSETLNKEQVLGIRDLTRYDPGVAVVEQGNGASGGYSIRGVDKNRVAVSVDGVAQIQAFTVQGSLSGYGGRGGSGAINEIEYENISTVEIDKGAGSSDHGSGALGGAVAFRTKEAADLISDGKSWGIQAKTAYGSKNRQFMKSLGAGFSKDGWEGLLIRTERQGRETRPHGDIADGVEYGIDRLDAFRQTYDIKRKTREPFFSVEGERESKPVAKLAGYGKYLNNQLNRWVKERIEQNQPLSAEEEAQVREAQARHENLSAQAYTGGGRILPDPMDYRSGSWLAKLGYRFGGRHYVGGVFEDTKQRYDIRDMTEKQYYGTDEAEKFRDKSGVYDGDDFRDGLYFVPNIEEWKGDKNLVRGIGLKYSRTKFIDEHHRRRRMGLLYRYENEAYSDNWADKAVLSFDKQGVATDNNTLKLNCAVYPAVDKSCRASADKPYSYDSSDRFHYREQHNVLNASFEKSLKNKWTKHHLTLGFGYDASKAISRPEQLSHNAARISESTGFDENNQDKYLLGKPEVVEGSVCGYIETLRSRKCVPRKINGSNIHISLNDRFSIGKYFDFSLGGRYDRKNFTTSEELVRSGRYVDRSWNSGILFKPNRHFSVSYRASSGFRTPSFQELFGIDIYHDYPKGWQRPALKSEKAANREIGLQWKGDFGFLEISSFRNRYTDMIAVADHKTKLPNQAGQLTEIDIRDYYNAQNMSLQGVNILGKIDWNGVYGKLPEGLYTTLAYNRIKPKSVSNRPGLSLRSYALDAVQPSRYVLGFGYDQPEGKWGANIMLTYSKGKNPDELAYLAGDQKRYSTKRASSSWSTADVSAYLNLKKRLTLRAAIYNIGNYRYVTWESLRQTAESTANRHGGDSNYGRYAAPGRNFSLALEMKF
The following text describes a protein:
Function:
Required for the assembly of cytochrome c oxidase.
Subcellular Localization:
Mitochondrion intermembrane space.
Sequence:
MSNKPAPKSEDKAEEWSGPAATRFDKYAATQPHKAYSEYFDPCQEAADKSIRCLKRNGGERAMCTDFFQAYRDCKEQWQNARKEARRNTSWFGK
The following text describes a protein:
Function:
Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to eukaryotic elongation factor 2 (eEF-2). Fragment A is the catalytic portion responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A.
Sequence:
MLVRGYVVSRKLFASILIGALLGIGAPPSAHAGADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGNYDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQAKALSVELEINFETRGKRGQDAMYEYMAQACAGNRVRRSVGSSLSCINLDWDVIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTALEHPELSELKTVTGTNPVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGIADGAVHHNTEEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPAYSPGHKTQPFLHDGYAVSWNTVEDSIIRTGFQGESGHDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAIDGDVTFCRPKSPVYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQKTVDHTKVNSKLSLFFEIKS
The following text describes a protein:
Function:
Does not seem to have conserved a kinase activity.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MGMEALRFLHVIFFFVLILHCHCGTSLSGSSDVKLLLGKIKSSLQGNSESLLLSSWNSSVPVCQWRGVKWVFSNGSPLQCSDLSSPQWTNTSLFNDSSLHLLSLQLPSANLTGSLPREIGEFSMLQSVFLNINSLSGSIPLELGYTSSLSDVDLSGNALAGVLPPSIWNLCDKLVSFKIHGNNLSGVLPEPALPNSTCGNLQVLDLGGNKFSGEFPEFITRFKGVKSLDLSSNVFEGLVPEGLGVLELESLNLSHNNFSGMLPDFGESKFGAESFEGNSPSLCGLPLKPCLGSSRLSPGAVAGLVIGLMSGAVVVASLLIGYLQNKKRKSSIESEDDLEEGDEEDEIGEKEGGEGKLVVFQGGENLTLDDVLNATGQVMEKTSYGTVYKAKLSDGGNIALRLLREGTCKDRSSCLPVIRQLGRIRHENLVPLRAFYQGKRGEKLLIYDYLPNISLHDLLHESKPRKPALNWARRHKIALGIARGLAYLHTGQEVPIIHGNIRSKNVLVDDFFFARLTEFGLDKIMVQAVADEIVSQAKSDGYKAPELHKMKKCNPRSDVYAFGILLLEILMGKKPGKSGRNGNEFVDLPSLVKAAVLEETTMEVFDLEAMKGIRSPMEEGLVHALKLAMGCCAPVTTVRPSMEEVVKQLEENRPRNRSALYSPTETRSDAETPF
The following text describes a protein:
Function:
Mixed specificity lectin with anti-HIV activity. Binds to HIV envelope glycoproteins, including exterior membrane glycoprotein gp120, and inhibits viral entry into cells. Binding to gp120 is dependent on gp120 being glycosylated, and is inhibited by mannose, glucose and N-acetylglucosamine.
Sequence:
SLTHRKFGGSGGSPFSGLSSIAVRSGSYLDXIIIDGVHHGGSGGNLSPTFTFGSGEYISNMTIRSGDYIDNISFETNMGRRFGPYGGSGGSANTLSNVKVIQINGSAGDYLDSLDIYYEQY
The following text describes a protein:
Function:
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein.
Sequence:
MSVRTQSSEEPAETVHRAGFACFVGRPNAGKSTLTNALVGQKVAITSNRPQTTRHTVRGIVHREDAQLILVDTPGLHKPRTLLGERLNDVVRTTWAEVDVIGFCLPANEKLGPGDRFIAKELAGIRKTPKVAIVTKTDLVDSKTLAEQLIAIDQLGKELGIAWAEIVPVSATANQQVDLLADLLTPLLPEGPALYPEGDLTDEPEQVMVAELIREAALEGVRDELPHSIAVVVEEMLPREDRPADKPLLDIHANVYIERPSQKGIIIGPKGKRLKDVGIKSRTQIEALLGTPVFLDLHVKVAKDWQRDPKQLRRLGF
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEKAKRQGRPAAASTKADTSTAQSNPFEVKVNKQKFQILGRKTRHDVGRPGVMRSRAHKKRTQTLLKEFKERGKSNVFKDKRIGEYDNKISPEEKMMKRFALEQQKKFEKEHIFNLNEEEDLTHYGHSLADIEKLDDIVDSDSDTEEKGMLSEELTAAHFGGGGLLRKKSLTGQQDEASGQTKSRKELIEELIAKSKQEKRERQTQRENTQELTEKLNSDWKEIQSFLLHRTSRSETEKQVEEKPKPDEYDIMVRELGFEMKVQPSNRMKTEEEVAKEEKERLLKLEADRLRRMRGEDEPETKKTPKHMSADDLADGFLLDKDDRHFLSYKDGKPNIEDNENEMNEKEGEESEEESDVEPESVDSYSDCEDDMEEAHISEAQERQIKCNKNKLQTKAQSSIREAAKLELPYLFDAPDSFEQFKALLSEKPIEEQLLVIERIQKSNHPSLAVGNKAKLEKLFAFLLEYVGELACMEPPELKAIDSLVPTLYNLCQMFPKAASNHVKFILQDAVHDLEKIQEVKSCMPFPGLKMFIYLKIIAALFPTSDFWHPVVTPSVVYMSLLLTKCPVTTLQDVVKGLCICCLFLEYVSLSQRFVPELINFLSGILHMAVPNRKEQGYTLIYPFGSLKNQLDLLVVSEKADSETWQKQSFPLHMISRLKEKSRTEMNHLRLSCLGLCLDLIKRCAAMYGSLPSFREIVQPIEILLSSHMPVKQYPKLLQELCDDVLKQLKVKGQYCPLVCEKKKPVPLKLFTPKIVKVLEFGRKQESNKKEQERKRLIHKHKRELKGAVHEIRKDNQFLARMQLAEIMERDSERKRKVKQLFSSLAQQEGDWKAMKRKKF
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MFIRNRPSPLPLNTPEPQLRRALPTESDAKSTSLNGLLQELHNADRRDSTPHGDSASTQIGHSSFEYLDLKRTAQLRAQASQTRLAERLTASISAAEEAHPLGHSSMPLPSMPDRSDELNSDDFHISDFFDEASSKHKHTVVKAAISSWNQLPGFTTDLFQGMIRSEYTQLTPVQTVVPMLLVHGYNVICSAPTGSGKTLAFLVPLIIHMQRVRLMWPDDPNLQSTCYALVLTPTRELAMQIHSVLLEIISQSSITLTTSLLIGGYTPTEMHPNVIVGVPGKVEHFVLGYNSHKYSLRKCSYIVLDELDELLDAGFIEQVSTILKVCARDKQIVGTTATLSKQAHKVVEDAGLINRDCLRKTFKCAMAGSVLQPNVRIAQIFVEFSSSLLGNQTSLSVATTNPLLPDPSTYLSKQEILASILQVHYSTRPTSQTIIFLASKENVDSLLEYLLRSKAKDSYSALYHCEVAAFHSGQEQQKRTTVISRFRANQIQILITTSGGGRGLDFPSVCLIINYDIPRCAEYYVHQIGRTARGMATGTALTLVDLNDDVKYLAELAVRVAGVRKRLSKDATYKTNVYLAQQKLGQHPPFVPLVRTGHGLANIKNLRNTGLASENGREEVQPSLHPTLHILSPNFIYPLSAQYSLPPEYHSAVRTAAALGICDLPGAQVVLDISNLSASAKRQLLKAQTIEYLSQAFDATVLRPGESKGEKLQITIIAKTRGALDNCLAHVNNLVAEADM
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYEDEQTMFMCNTLQPGCNQACYDKAFPISHIRYWVFQIILVCTPSLCFITYSVHQAAKQRERRYSFLYPLLERDAKKARTLNGVLAPGADGGTKDEPECLEAKELPSTPPRRAKAKRQEGISRFYVIQVVFRNALEIGFLAGQYFLYGFNVPAIFECDRYPCVKEVECYVSRPTEKTVFLVFMFAVSGICVLLNLAELNHLGWRKVKAAVRGVQARRKSLVEVRKKDGAALTPAPTLGRTQSTPVCPHHANQEMRRRCREVFIGLGIRSYNLQQRQRRRGRPSISRRLASLALLRRSSSCSQRRSCRPSERRRNSCCCRHLHAFSWRRRNSWGGGTQPQPPTRNHESCPTRARSRGSAGQ
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
QECKCHGVSGSCTLKTCWVTLPHFREVGYALKDKYEQAVMVEAVRGRRHVVPTFLKLKIPQNNSKPAETDLVYVDRSPNFCEKDNATGSIGTYGRFCNRTSTQADSCELLCCGRGYKTFQYTRTGQCHCKFHWCC
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
Subcellular Localization:
Cytoplasm.
Sequence:
MKPSIVLYKSIPTDLHQRLAQHFTVNSFDGLTPDNQPELLAALQQAEGLIGSGGKIDQDFLQLAPNLRAASTISVGYDNFDVEALSQRGIALMHTPTVLTETVADTMMALMLSTARRVVELAERVKAGEWQESIGDDWFGVDVHHKTIGILGMGRIGMALAQRAHFGFSMPVLYTSRRPHEAAEQRFGARHCSLDTLLAEADFLCITLPMTEQTYHMIGREQLAKMKSSAILINAGRGPVVDEQALIAALQDGTIHAAGLDVFEQEPLPVDSPLLTLRNVVAVPHIGSATHETRYNMAACAVDNLINALTGTVKENCVNPQVLITH
The following text describes a protein:
Function:
Substrate-recognition component of the cullin-RING-based CBC(fem-1) (Cul2-ElonginB-ElonginC) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). Sex-determining protein; essential for the adoption of the male sexual fate in all tissues. The CBC(fem-1) complex mediates the ubiquitination and subsequent proteasomal degradation of tra-1. Promotes ubiquitination and degradation of cdl-1. May be involved in turnover of neuronal substrates, thereby impacting synaptic acetylcholine release and neuromuscular transmission.
Subcellular Localization:
Cytoplasm.
Sequence:
MTPNGHHFRTVIYNAAAVGNLQRIKVFTINSRNDRQWIIDCFNSDQDGRYPLVIAARNGHANVVEYLLEIGADPSVRGVVEFDNENIQGTPPLWAASAAGHIEIVKLLIEKANADVNQATNTRSTPLRGACYDGHLDIVKYLLEKGADPHIPNRHGHTCLMIASYRNKVGIVEELLKTGIDVNKKTERGNTALHDAAESGNVEVVKILLKHGSVLMKDIQGVDPLMGAALSGFLDVLNVLADQMPSGIHKRDALKLLGSTLLDKKMDAMSAMNCWKQSMEVPLHADDLRLVREMETFFEPQEVYEYQREAQNIAQVELLDGNIEAQRMQALVIRERILGGAHTDVHYYLRFRGAVYCDMGQMNRCYDLWKHALELQQKHFAPLYYGTITTLQSFHETFSMSLNDFVNNHHANRNLRVRSSWVKYVFNGVCLELERAAAWTGAPLLEDTECCGKERCQHATEESEYKKLVYVAVHLVNVLERLSLPSAHIDDSDEEKEPKADVRRLMIVCHELHIPLLHHTLEERIPDSNSAELGLPKAAVLEQLLELDLDVNATDKNNDTPMHILLRAREFRKSLVRALLVRGTWLFARNRHGDVVLNVMKRMKALNHANFDDLPLGRHITLAGLVANAMRVKYPKKFVGVEEQMPLELRRFYLAH
The following text describes a protein:
Function:
Provides the (R)-glutamate required for cell wall biosynthesis.
Sequence:
MKQHLSHTPGPIGVFDSGYGGLTILNKIREALPEYDYVYLGDNARTPYGTRSFEIVYEFTLQAVNKLFEMGCHLVILACNTASAKALRSIQMNDLPGIDPERRVLGVIRPTVECIGGITQSRHIGVLATAGTIKSESYPLEIHKLFPDIQVSGMACPMWVPLVENNESQNEGADYFIRKYIDQLLSKDPEIDTMILGCTHYPILLPKIQEYTPKHIRIVAQGEYVAESLKDYLSRHPEMNAKCTQNGSCLFYTTEAEEKFVESASSFLNQQIDVRRISLE
The following text describes a protein:
Function:
Involved in the signaling pathway that regulates cell wall function, including cellulose biosynthesis, likely via an 1-aminocyclopropane-1-carboxylic acid (ACC)-mediated signal (a precursor of ethylene).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MDNHGRRKQSSSLCAAGLALVLVCCSTASMALTPDGEALLELKLAFNATAQRLTSWRFTDPNPCGWEGISCSFPDLRVQSINLPYMQLGGIISPSIGKLSKLQRLALHQNSLHGPIPAEIKNCTELRAIYLRANYLQGGIPSEVGELIHLTILDLSSNLLRGTIPASIGSLTHLRFLNVSTNFFSGEIPNVGVLGTFKSSSFVGNLELCGLPIQKACRGTLGFPAVLPHSDPLSSSGVSPISNNKTSHFLNGIVIGSMSTMAVALIAVLGFLWICLLSRKKNMGVSYVKMDKPTVPDGAKLVTYQWNLPYSSSEIIRRLELLDEEDVVGCGGFGTVYKMVMDDGTAFAVKRIDLNRQGRDKTFEKELEILGSIRHINLVNLRGYCRLPTAKLLIYDFLELGSLDCYLHGDAQEDQPLNWNARMKIALGSARGLAYLHHDCSPGIVHRDIKASNILLDRCLEPRVSDFGLARLLVDKDAHVTTVVAGTFGYLAPEYLQNGHSTEKSDVYSFGVLLLELVTGKRPTDSCFLNKGLNIVGWLNTLTGEHRLEEIVDERSGDVEVEAVEAILDIAAMCTDADPGQRPSMSVVLKMLEEEILSPCSSELYYEQHLEI
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MLVVFQRVVRATVLVGRKDTIRTVKTHSGAKKRWILTEDGKSFKRKHAGAQHLNRDTSSSTRARQRQWEEANTIQKRVLKRLLPFK
The following text describes a protein:
Function:
Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of free histone H4 in the cytoplasm. The complex is also found in the nucleus, however it is not certain that it modifies histone H4 when packaged in chromatin. Histone H4 'Lys-12' acetylation is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSANDFKPETWTSSANEALRVSIVGENAVQFSPLFTYPIYGDSEKIYGYKDLIIHLAFDSVTFKPYVNVKYSAKLGDDNIVDVEKKLLSFLPKDDVIVRDEAKWVDCFAEERKTHNLSDVFEKVSEYSLNGEEFVVYKSSLVDDFARRMHRRVQIFSLLFIEAANYIDETDPSWQIYWLLNKKTKELIGFVTTYKYWHYLGAKSFDEDIDKKFRAKISQFLIFPPYQNKGHGSCLYEAIIQSWLEDKSITEITVEDPNEAFDDLRDRNDIQRLRKLGYDAVFQKHSDLSDEFLESSRKSLKLEERQFNRLVEMLLLLNNSPSFELKVKNRLYIKNYDALDQTDPEKAREALQNSFILVKDDYRRIIESINKSQG
The following text describes a protein:
Function:
Epoxide hydrolase involved in the biosynthesis of cucurbitacin and mogroside tetracyclic triterpene natural products (e.g. siamenoside I and mogrosides IV, V and VI). Cucurbitacins have cytotoxic properties and exhibit deterrent taste as a defense barrier against herbivores. Mogrosides are nonsugar highly oxygenated compounds used as high-intensity zero-calorie sweeteners; they also possess pharmacological properties such as regulating immunity, lowering blood sugar and lipid levels, protecting the liver, and acting as antioxidants and antitumor agents. Catalyzes the hydrolysis of aromatic epoxide-containing substrates, such as the conversion of 24,25-epoxycucurbitadienol to 24,25-dihydroxycucurbitadienol.
Sequence:
MFRQQADINQTLAYQNSSEHKQAVQIAQLGLAQFAFGPTHMVPALPSDTSRSLAPVPALGSPLPVNSSGAEHDADTPRTMAAMTVRHRQLEANGISMHVAEAGPVDASAPAVLFVHGFPELWYSWRHQMDYLAARGYRCVAPDLRGYGGTTAPPEPSSYTAFHIVGDLVALLDALHLPQVFVVGHDWGAIVSWNLCLLRPDRVRALVNLSVAFMPRNPGVKPLEYFRAAYGDDYYVCRFQEPGLEAEFAAFDLKSFFKLALTLRATGSSVMDLRKMQTYAKQIELPSWLSEEDVNYLASVYSKTGFAGGVNYYRCLDLNWELMAPWTRAKVQVPTKFIVGDGDLAYHHPGVKSYIHKGGLKRDVPMLEEVVVIKGAGHFIQQERAQEISEHIHDYIKKFEAGVLPPLRVSKL
The following text describes a protein:
Function:
Prospore-specific dityrosine transporter responsible for translocation of dityrosine through the prospore membrane and required for the formation of the outermost layer of the spore.
Subcellular Localization:
Prospore membrane; Multi-pass membrane protein.
Sequence:
MGSEPFQKKNLGLQINSQESGTTRSTFHSLEDLGDDVINESWDQVNQKRANIDHDVFHEHPDSSPSLSAQKAKTKEEEVAVKSSNSQSRDPSPDTQAHIPYTYFSKDQRLIIFGIIIFIGFLGPMSGNIYIPALPLLQREYDVSATTINATVSVFMAVFSVGPLFWGALADFGGRKFLYMVSLSLMLIVNILLAAVPVNIAALFVLRIFQAFASSSVISLGAGTVTDVVPPKHRGKAIAYFMMGPNMGPIIAPIVAGLILMKGNYWRWLFGFTSIMTGIALILVTALLPETLRCIVGNGDPKWGDKKDERENNESPFFEGNKISHRRLFPDIGIRKPVNNDAFFQENFPKPPKAGLTLYWKMIKCPPIIITSVSTALLFSSYYAFSVTFSYYLEHDYRFTMLEIGAAYVCPGVAMLLGSQSGGHLSDYLRSRWIKSHPKKKFPAEFRLLLNLIGILLTICGTIGYGWAIFFHYHFVVLLVFSALTAFGMTWCSNTSMTYLTELFPKRAAGTVAVSSFFRNVGAAISSAIILQLCNAMGIGWCFTGLGLCSSISLIGILYLLIFQRKYTAKEF
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
Subcellular Localization:
Nucleus.
Sequence:
MVVAEKRLIDEYFKVEDIDQAGQSFKRVSRIKCKSKSGEVDMELDVNIDIYPIDKGSEYRVLIVRSLGISQEMDQGKYKPEFSQIDNELLEKFQYAMFGRVFKMIKDQNKMINVFASFGGLILKLSGKSEELDKFADDQRVYLLMRKA
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTSADPPPTSSRLAHRQQPHVTSHGLSPPLTLGLNALHRLRLRLRLRLLPLLLLPLLLLPPPTRAARPLPPTSETLILTVVGTTLPARRSSAPSLPELLDAPAAPMAAPPPAAEGPDAVEIREVWADNLEQEFAVIRDVIDAYPYVAMDTEFPGIVVKPTGSYSCQSDVNYATLQGNVNILKLIQLGLTLSNEAGALPPRGTGGRGCIWQFNFRGFDPRTDPSSSISIDLLRRSGIDFDRFAAEGVDSTRFSELMMTSGLVLSDSVQWVTFHSGHDFGYLLRLLTGREMPNTLDEFLELTKTFFPVMYDVKHLMRFCSGLYGGLSKLGELLKVERVGTSHQAGSDSLLTLWCFLKVKNLYLKESVKLYDGLLFGLIPGEGVIG
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MAAAASSPATTPTAHWSRFEQERDLTLRELVRRVTGLQERGAGEGEPGHFQAALGFAWSNVRFHRFLDVSSHKVEKTIDGIYEKLVVHSELVKAASWKKLTEKFLNLPLPTTEGTKTETHYALLSLLLCLSDSPSNTSYAEKPREKEVEKEEFDWGKYLMEGEEFDFPPDLETPEWSDASNDEEDAEPLSREDSGIQVDRTPQEDQDQNKKSASHVTWKGEPDARTWLEQHVVAPYWTGRAVRFSHSLHFHSNLAAVWQQHLYNTDPLYMPEERVIVTETQVIRETIWLLSGVKKLFIFQMNEGKITVRNDIMVTHLTRNSLRAMLERIAAYGQVVFRLQKFIDEVMGHGSESGMHGTMSTPKKSIEAPFRTYQAFMRALYKYFINFKEELTEIERCIINSDTTITLSIVMEKLSPWLAQLKVLHKVFSTGVAEVPPDTRNVVRASHLLNTLYKAILDYDNVGEASEQTVSLLFSLWVETVRPYLQTVDEWIVHGSLFDPAKEFIIQRNKNVPVNHRDFWYATYTLYSVSEKTENEEKMSDNASASSGSDLAPSSRQHTMVSFLKPVLKQIIMAGKSMQLLKNLQCTDGSPQQAAFRDTERKSLYMLFLESVQSRLRHGEEPAQDIVTEQQVTKQSLIKMQSIAERHLELDDVHDPLLAINFARLYLEQNNFHETLAADDVCVDRSSESVTCQTFELTLRSCLYPHIDKQYLQCCGNLMQTLKKDYRLVEYLQAMRNFFLLEAGDTMYDFYTSIFDKIREKDTWQNEPFLNVQLQEAVGQRYPEDSLRLSILCENIDIAKKKLPVHTLDGLILSYKVPWPVDIVISVECQKIYNQVFLLLLQIKWAKYSLDVLRFHELVKAGEKTQHEEGAIFVQEALSQFGAQTDPIKQQTHRMFLLRMKLMHFVNSLHNYIMTRILHSTGLEFQHQVEEAKAVFTNLAPKYHDILKTLTTKMRW
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
Subcellular Localization:
Nucleus.
Sequence:
MDYFLSLFISLADSLSSAWNCDIEEHFGDALRVADSLLQEHYEVTIQRVPREIACTSYSKLRRVWKDILEGDGGSTSTRHLLAKLLALLGLELELPVSKDLGRHTFLENSQEFFEKGWERSPAVITNGTGRVFEALRKDFPAQDSSELLRTLVGASISCPPVSSDELDPCQLFKEIHDDLGRPLIYQQDIRLVKCTTGDCVEQHYFSRNGEGQIVRVEDCIKAFELGYTVAVRGIEFRSKVVAELAQSLGFQLGQASIGANLYLTPSNAQGLGRHYDDHCVFVVQLAGTKRWSINPAATVVLPRLYAPRLVPKAEVQSRELAESVLTEGSALYIPRGFAHQASTSEDGNTSKSPGRGKRKHCTLKTTTGNCPTTTSKFSLHLTFGVEVELPFEWQGFIHIALHLWFLRENPPQSRDSRLCKTLLHFTVWSMADNAVRELRKACSVAMPATYNKSHATFKELIKKIASHAEESERAINGEECAAGLSWLGHLPGTQSLETDFKLAIDSTIKEDRFPEMYVTARANFVVRALYDDAVFSEARESFALIECVSQAVQAVTTWNTDLATAREAFVVRPTGHCREGKLRAFNCSHAEPRHRAVGIQEARREILLVASHDRHWQAGVHSALVTGRVSLPENSSNVAGQLVELEADIEMCEAVVRGDPVAVNFGVGLSHRLSLSIRSPTSGSLQTAPSPEGRVTALPSSWSSSNRRSRPKLQRSGTELSWVVSEQDSQRLHPRKVALEARAALGLSDEVGVYVEIGVGDNAEVLVPLAVEVEDASIATDEAGVLADRSWPVTPPDICETRRKEEEATIKVDSSKLETLILTAASGASVAIDAALIGTPPGTGKDEIEAPAVRVCSANYLGGLRSWQELDHSGEAAGSKDQKELRKLHRQKQS
The following text describes a protein:
Function:
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (By similarity). Has a role in regulation of fat storage.
Sequence:
MIVIRNWQRISYLSFCRFSTRSLSIQQFQKTPLLLVVRQQGSARLKMTSSPPEIVPQQPLDALLLNKTDTEQEIFLTKYPNYDGRDILIAILDTGVDPSLPGMQVTTTGERKMFDVIDCSGAGDVDTSITRTVKDGVIEGISGRKLAIPEKWKCPTGQYHVGLKPIFELYTKGVKSRVISERKEDVVGPSHNIAASEALKQLTEHEKVVGGTSEKTSDKWAREDFACKVDFLKSMASVADVGPVADVVTWHDGEMWRVCIDTSFRGRLGLGNVLGTFRETGDYAYLTNKDSVVYTVRVSPDGNLTEIVVPSGAHGSHVAGIAAANYPDNPQKNGLAPGAKILSLNIGDHRLGAMETGQAMTRAFNMCAELNVDIINMSFGEGTHLPDVGRVIEEARRLINRRGVIYVCSAGNQGPALSTVGAPGGTTTGVIGIGAYLTSESADTLYGVYKPVESSIYPWSSRGPCQDGKLGVSLVAPAAAFAGVPQYCRQSMQMMNGTSMSSPNAAGNVACMLSGLKQNNLKWTPYTVRMALENTAYMLPHIESFSQGQGMIKIATAYEKLSEILVNKVFPPRLTHFEINVSNHCKKSKGVYVREPNWNGPQEFTIGVEPIFQNHLSDNNLPAISFEKQIILQSTAPWVSHPQTMFVVAQERTMVVTVDASKAPKGANYTEIVGIDTADPSLGPIFRIPVTVINPEKVAVDQYTSRLVGKSGVTERRFVEVPSWATSAKITLRSTNKDEMDRFTLHTVYIEDDKCSRNTETQKIQGPIGNEWSKSITVQGGKTLEACVVRAWSRGKNPVDVDMTIDFFGVKKPTSISLIHGATNTPIRFQAAPTKSIDVSPSISLKSLVVSLKPQSAKVEPLGPRDMFLTSGLQINRLLLTYQLKVQKPSEVQLQLAGLTPYLYESPVDCVLFQIFGANKSFVGASSSYPDRWTQKLEKGDYTIQAQIRYPDDQVLQGMKELPLLVHVKLGNKISVDLAASASDATLGKECKFAGKALLPNQEMTVYAMNIADDKLPKTIVPTSGSFLAGTFSALKDSDLSDVDKSEVIYFLSEYSTRPTKGLSMVTTKKDTNQNQEMTDAIRDLEVSWVQKLTDEKAAKEFFEACLQKYPDHLPLLQNRVKQLMQAKLVDQTPENVQKIIELCGQILQITKPNETLQFSSVKQEHDDDLLTVDKWLALTGGSEDQRKDVVKLISQFEERKKSIILALQALSSLEQDIEVRKSKFDVPASLRFGGITPLIFGGKQGEVINKKSEGYEALKSKSEQIDATVSEELKKLDSNWTGNQFYVKLLVWLSADDTKTALISAKHAAALGQFGRCAKLLNKAGDELKSSATDSQAVDTSLAEVCESLEWNHLATHFKNSALIKNRTSYRLF
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Sequence:
MTAVNSKVLEFCQFMGRLKHLPRTGWVIRDIPNCETVAGHMYRMAMLTFLLETKDVDIQRCLKMCLVHDMAESIVGDLTPHCGVSVEDKHRQEEEAMETLIKLVPELSGEDMKSLFMEYENQETQEAILVKDLDRFDMICQAYEYEESHKTPLALQEFFVATEGRFKHPEVKRWVDELNQKRALLTAPVANGEADKPLNS
The following text describes a protein:
Function:
Involved in C-to-U editing of mitochondrial RNA. Required specifically for editing the mitochondrial NAD2 transcript.
Subcellular Localization:
Mitochondrion.
Sequence:
MIVVTSFVRNSAVAAVASTPWNVRLRELAYQSLFSESISLYRSMLRSGSSPDAFSFPFILKSCASLSLPVSGQQLHCHVTKGGCETEPFVLTALISMYCKCGLVADARKVFEENPQSSQLSVCYNALISGYTANSKVTDAAYMFRRMKETGVSVDSVTMLGLVPLCTVPEYLWLGRSLHGQCVKGGLDSEVAVLNSFITMYMKCGSVEAGRRLFDEMPVKGLITWNAVISGYSQNGLAYDVLELYEQMKSSGVCPDPFTLVSVLSSCAHLGAKKIGHEVGKLVESNGFVPNVFVSNASISMYARCGNLAKARAVFDIMPVKSLVSWTAMIGCYGMHGMGEIGLMLFDDMIKRGIRPDGAVFVMVLSACSHSGLTDKGLELFRAMKREYKLEPGPEHYSCLVDLLGRAGRLDEAMEFIESMPVEPDGAVWGALLGACKIHKNVDMAELAFAKVIEFEPNNIGYYVLMSNIYSDSKNQEGIWRIRVMMRERAFRKKPGYSYVEHKGRVHLFLAGDRSHEQTEEVHRMLDELETSVMELAGNMDCDRGEEVSSTTREHSERLAIAFGILNSIPGTEILVIKNLRVCEDCHVFLKQVSKIVDRQFVVRDASRFHYFKDGVCSCKDYW
The following text describes a protein:
Function:
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MAVMTAEESARRFRMVYVGASLVAMFISTYKTMYTDMNAPPAAPGPAPLDGTILQDLVQDNSARFRWGTYRPGLYLGLKSRTAPEFVSTGLLWGSQIEDVSQIRHQCRQEDRLQRYGWLEHDGTNYGLQKVEDQFNRVELTTSFAQLQGEDVQGWAARVQAGPLSPRDEVLRRKQVPSNKLSLFFYVDLGCGDESLDLECRHKLQNLMEVAAEPTPLQCGAEGHKCVQMVLESEAPEGDKSTAPLTFQMQVQLKTRETVRGVELHYAGLKDTNVLNVKEKLVSLAQRPGGDGNKDLRADKEILLDNFVEDGSTLVVVQAIVEVDAATFEEEDVVLDVLFNEAAASSAADGVKAPIDSLITGKLTEYSQQFDDKFEQAFHLSTKTWPTNGGEEAAFNESVVTFAKAAFSNLIGGTGYFYGSSLVQHDPESPEVIESPVKPLFTAVPSRSFFPRGFVWDEGFHQIGVSAFDDSVSRDVIAHWLGLMEEDGYIAREQILGQTARRRVPAEFLVQHVEHANPPTLLLALEKMIAWHQDADSDQELQQFVRTIFPFLKRWYSWFLKTQYGPRSASFRWRGRHPNDGKLISNTLSSGLDDYPRASLPSENEMHVDLLSWMIRSSDIMAKLAASIDQDNEVQRFETNSAHFLTGLDQHHWNEEAQSYFDVGEHSEDGLIEYQVAIRCRNEQGQVVDATAPIAQIETKEVKCPASHPNYMFPLGDGRGGLQMLPVFIPHTTKLQHVKHVGYVSVFPLLLKVLPPDSPKLLALLKQITDPTQLWSPFGLRSLSTQDQFYEQENAPGDNPYWRGAIWMNMNYLALDALYHYAQPSTGSPFQTDFSQAYSALRVNVVAYIYREYERTGYLWEQYNGNIRAGQHYGQGQRCHPFSGWTALVVNIMAETY
The following text describes a protein:
Function:
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKGLPETRTDAAMSELVPEPRPKPAVPMKPMSINSNLLGYIGIDTIIEQMRKKTMKTGFDFNIMVVGQSGLGKSTLVNTLFKSQVSRKASSWNREEKIPKTVEIKAIGHVIEEGGVKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKRLNDNGGLPPGEGLLGTVLPPVPATPCPTAE
The following text describes a protein:
Function:
Adapter protein which may play a role in the regulation of apoptosis in response to PDGF.
Miscellaneous:
MISCELLANEOUS: The sequence described in PubMed:11095946 is over-extended by 57 aa at the N-terminus due to the presence of an uncorrected 5' mismatch compared to the reference genome sequence.
Sequence:
MQQEGGPVRSAPCRTGTLEGSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL