lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Microtubule-severing enzyme that negatively regulates cell migration and wound healing. In migrating cells, targets dynamic microtubules (MTs) at the leading edge and severs them, thereby suppressing motility. Microtubule severing releases ARHGEF2 which activates RHOA, which in turn regulates focal ahesion turnover via focal adhesion kinase, as opposed to F-actin polymerization, to suppress cell motility. Negative regulator of axon regeneration that suppresses axonal growth by selectively severing dynamic MTs in the distal axon shaft and growth cone (By similarity). Contributes to proper cell branching during endothelial and neuronal development (By similarity).
Subcellular Localization:
Cytoplasm, cell cortex. Note=Localizes at the leading edge of migrating cells.
Sequence:
MHWTPEHAQPLNQWPEQHLDVSSTTPSPAHKLELPPGGRQRCHYAWAHDDISALTASNLLKRYAEKYSGVLDSPYERPALGGYSDASFLNGAKGDPEPWPGPEPPYPLASLHEGLPGTKSGGGGGSGALGGSPVLAGNLPEPLYAGNACGGPSAAPEYAAGYGGGYLAPGYCAQTGAALPPPPPAALLQPPPPPGYGPSAPLYNYPAGGYAAQPGYGALPPPPGPPPAPYLTPGLPAPTPLPAPAPPTAYGFPTAAPGAESGLSLKRKAADEGPEGRYRKYAYEPAKAPVADGASYPAADNGECRGNGFRAKPPGAAEEASGKYGGGVPLKVLGSPVYGPQLEPFEKFPERAPAPRGGFAVPSGETPKGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGAAAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAAAGAGLPGLQRPLSYKDLEAALAKVGPRASAKELDSFVEWDKMYGSGH
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTSFFDSPSKVIGASIALRAVLLVYGAWQDAHSPIKYTDIDYFVFTDAARYVSRGASPYARDTYRYTPLLAWLLLPTTWDSIPGFFAFGKALFALADVVAGWLIAKVLVSAYGMSPSRALKYASVWLLNPMVANISTRGSSEGLLGVLVVGLLWAVLSRRVSLAGVILGLGVHFKIYPFIYGPAVVWWFDAERDGSGSPRGTATARAAREKDDGQDGQGILSKAVDFLTPARIHLTLVALATFSALNVSMYILYDLPFAQNTYLHHLTRIDHRHNFSPYSTLLYLSAAGGARTAFESLAFIPQLLLSVVVIPLVLGKKSLAGTMLAQTFAFVTFNKVCTSQYFLWYLIFLPFYLPSSSLMKNPRKGILVGLLWVIAQALWLQQGYNLEFLGLSSFVPGLFLASLFFFAVNVWILGIIVEDVGGSA
The following text describes a protein:
Function:
Component of the NatC N-terminal acetyltransferase.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSVKESLSLLNSMQGNVKIGNVEPAKGNEGYVDNAGYVDCTKSYFEATKSLKEEQLVCDPKFTLLDSISAFEIMEPKMDSGIDYQPLRVDFSRDLSYLEILALMDLIVSAEKEWHYGSPLSESLLCSAHVFSICKSPISQVGDSGFSSGSGRNTTDIVLFPFVLAVIKCCDIVHREFLMGNLYDEEDISSFSYHMSFLQNYPIEKLNYLLQSSIEYLASEVIKFSAELRQIIEGILNRIQLRIGILRVYERSDIKTTIDALHLIKNLVPEIQNTVSVVDSSIKESILKQYWDFRVQAQLVATAPVRNIPPTGIEHSYQRILYFADDMLLILNSHTLASSLAVYQFCLDFTRLNRTPEPYVRSSLQALITANNAVNLRDQPTSYMLECIREFSGLPSNFYNPNTRTVIEKNSISSAYGPLVESLIAHSTNIMVDLVRICSHNPCRFRRNLINLLPEITVAHFEAEALDLKFVAKSLPSNGPFSSFIYHVKLNAIEHILLSSFEQKLHQPYQWPHFFAVLDHVFSIHQTHLELHGKDRNTPPMAKTFVTYLHRILNAIKETYSGYLLLTVLCMRLNIIKTPSFTLDEKIQESYYMAHYRPLINLRQPKPLLRSEADCIIKNLQNFSTDDLIIKSNEKFTAAKNSLINVIKSGFEQNEFINPYFLQTNYLKNLLCCCITNLVSLAILSKDHSANLKIVEIPGNPLPSLSRT
The following text describes a protein:
Function:
Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity). Involved in resistance to arsenite and antimonite but not to arsenate.
Sequence:
MTATQTPAKEVVEPNSEDTEFVFFSGKGGVGKSTVSCATATWLADNDYDTLLVTTDPAPNLSDIFNQDIGHEVTAIDDVPNLSAIEIDPDVAAEEYRQETIEPMRALLGDEEIQTVEEQLNSPCVEEIAAFDNFVDFMDSPEYDVVVFDTAPTGHTIRLMELPSDWNAELEKGGSTCIGPAASMDDKKADYERAIDTLSDESRTSFAFVGKPESSSIDEIERSASDLAELGISSQLLVVNGYLPESVCEDPFFEGKRADEQAVIDRVESTFDQQALATYPLQPGEIAGLELLSDVGGVLYDGEEATVDVDAATRRATNEDTVDFDTFTDADAVAEELVPVEETRYLFFTGKGGVGKSTIASTTAVSLAEAGYETLVVTTDPAAHLADIFEQPVGHEPTSVGQANLDAARIDQERALEEYRTQVLDHVREMYDEKDDTQIDVEAAVANVEEELESPCAEEMAALEKFVSYFEEDGYDIVVFDTAPTGHTLRLLELPSDWKGFMDLGSLTKGAAPANGGKYDEVIETMQDPSRSSFAFVMYPEFTPMMEAYRAAMDLQDQVGIETSVVVANYLLPEDYGDNAFFENRRAQQAEYLEEISERFDVPMMLAPLRQEEPVGLDDLREFGADVTGLDGVGEDDREEVTVS
The following text describes a protein:
Function:
Regulates lysine acetylation levels of plastid proteins related to photosynthesis. Involved in the regulation of the activation state of RuBisCO, which is controlled by lysine acetylation of RuBisCO activase under low-light conditions. Associates with alpha- and beta-tubulins and deacetylate alpha-tubulin. Does not seem to be required for the cellular patterning in the root epidermis. Involved in the regulation of melatonin biosynthesis by catalyzing the deacetylation of N-acetylserotonin to produce serotonin. N-acetylserotonin is methylated by acetylserotonin O-methyltransferase (ASMT) to produce melatonin (N-acetyl-5-methoxytryptamine) (Probable). Deacetylates melatonin to produce 5-methoxytryptamine. In vitro, deacetylates N-acetyltyramine and N-acetyltryptamine to produce tyramine and tryptamine, respectively.
Subcellular Localization:
Nucleus. Cytoplasm. Plastid, chloroplast stroma. Mitochondrion.
Sequence:
MSMALIVRPFFVPGSAGISGSRNICKKNQWRKYLLKPSGSSINCSFSTEKNPLLPSIQQLADARLIYSVSAALGHNKESHPECSARVPAIVNALEMNELTPKFRGSQILELANFKTATVEDIANVHDKAYVFGLEKAMDEASDSGLIFIEGSGPTYATSTTFQDSLIAAGAGMALVDSVIAASRNSVDPPIGFALIRPPGHHAVPKGPMGFCVFGNVAIAARHAQRTHGLKRIFIIDFDVHHGNGTNDAFTEDPDIFFLSTHQDGSYPGTGKISDIGKGKGEGTTLNLPLPGGSGDIAMRTVFEEIIVPCAQRFKPDIILVSAGYDAHVLDPLANLQFTTATYYSLAKDIKRLAKEVCGGRCVFFLEGGYNLESLSSSVADSFRALLGEDSLASEFDNPAYLYDEPMRKVRDAIQRAKSIHCL
The following text describes a protein:
Function:
Component of the BTR double Holliday Junction dissolution complex, which is involved in homologous recombination during meiotic double strand break in the germline (Probable). Stabilizes and positively regulates the localization of the BTR double Holliday Junction dissolution complex component rmh-1 at nuclear foci during meiotic recombination. Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Negatively regulates sister chromatid exchange (SCE); ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. Participates in DNA replication and repair. Negatively regulates sister chromatid exchange (SCE). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes on chromosomes during pachytene in meiotic prophase I in oocytes. Co-localizes with rmh-1 at mid-pachytene and late-pachytene in meiotic prophase I. Localization at nuclear foci is dependent on rmh-1 during meiotic recombination.
Domain:
The N-terminal region mediates dimerization and homooligomerization. Both the helicase ATP-binding domain and the helicase C-terminal domain form intramolecular interactions with the HRDC domain in a ATP-dependent manner. The HRDC domain is required for single-stranded DNA (ssDNA) and DNA Holliday junction binding.
Sequence:
MIKNREIEVAPPRRTIQFGGYTFVEPDLNFKAPIFSCCGSIRDPSCEEREEEYIDNGHDEEPPVEVNRIQESTSFDEPVSSPPRYRPSENPGPSSSSYEPGHYSFNEYQQFPSRPQKRLVDPPIVDLDEEPPIVDLDDSFDNFHVGSTSEEVVSGDIAPEEEEEEGHDSFDDFESVPAQPPSKNTLASLQKSDSEIALNQQRHDMHGRFRGFLQDDSEEFSDEVGLLGADMNKELYDTLKSKFGFNQFRHRQKQCILSTLMGHDTFVLMPTGAGKSLCYQLPAVILPGVTVVVSPLRSLIEDQKMKMKELGIGCEALTADLGAPAQEKIYAELGSGNPSIKLLYVTPEKISASGRLNSVFFDLHRRGLLARFVIDEAHCVSQWGHDFRPDYTKLSSLREKYANPPVPIIALTATATPKIVTDARDHLKMQNSKLFISSFVRDNLKYDLIPKAARSLINVVEKMKQLYPGKSGIVYCLSRKECETVQMMLTKAGLSAEVYHAGLNDNLRVSVQRSWIANKFDVICATIAFGMGIDKPDVRFVIHYSLPKSIEGYYQETGRAGRDGMPSYCLMLYSYHDSIRLRRMIEEGNTTTGVRSMHLNNVLQVVAYCENVSVCRRKMLVEHFGEVYDEQSCRNSKTPCDICERQRKNAEAIRLFDVSTDALSILKCLPRMQKATLKYISELYRGALIKKSQEQAMRLGHTKLPFYSKGQGMSEQDALRFVRKLVIEGYIHERLYSVPNQAAAVFAYAELTEAGRDLANGKKTAKVYLHIVTCERKRKNAGLIELSNMNIVSEAQALKERHMVKHGDVFTRCLQDLTHLITAVAESSGLSGPYSIVSREGIEQIAALLPRTNSDLLRIDSMTQIKVTKYGRLIMELLATYWKQVDEREEEEMRNQLDKLKSGEIVMGGFATLQSDPGFPSVPYMKPLGGGGGCRGRGKKRAFSGFSSGRATKKPRATAPSARGKTSGRGGAKPATSLKRNMYPATSM
The following text describes a protein:
Function:
Non-specific phospholipase C (PLC) which assumes major PLC activity during inorganic phosphate starvation. Substrate preference is phosphatidylcholine (PC), but can also hydrolyze phosphatidylethanolamine (PE) with lower efficiency. Has no activity toward phosphatidic acid (PA). Plays an important role in the supply of both inorganic phosphate and diacylglycerol from membrane-localized phospholipids during phosphate deprivation. May be required for lipid-derived signaling molecules that positively modulate abscisic acid (ABA) response and promote plant tolerance to drought and salt stresses. May be involved in brassinolide-mediated signaling in root development.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MIETTKGGSGSYPIKTIVVLVQENRSFDHTLGWFKELNREIDGVTKSDPKSNTVSSSDTNSLRVVFGDQSQYVNPDPGHSIQDIYEQVFGKPWDSGKPDPNPGHPNMSGFAQNAERNKKGMSSAVMNGFKPNALPVYKELVQNFAICDRWFASVPASTQPNRLYVHSATSHGATSNDKKLLLEGFPQKTIFESLDEAGFSFGIYYQFPPSTLFYRNLRKLKYLTHFHQYGIQFKKDCKEGKLPNYVVVEQRWFDLLSTPANDDHPSHDVSEGQKLVKEVYEALRSSPQWNEILFIITYDEHGGFYDHVPTPVDGVPNPDGILGPPPYNFEFNRLGVRVPTFFISPWIEPGTVIHGPNGPYPRSQYEHSSIPATVKTIFKLKDFLSKRDSWAGTFESVITRDSPRQDCPETLSTPIKLRGTMAKENAQLSEFQEDLVIMAAGLKGDYKNEELIHKLCKETCVADASKYVTNAFEKFLEESRKARDRGCDENDIVYCVDDDDDHVVIPPQSHSEASNAAAQPKTQTSFFNKLFSCFIRHD
The following text describes a protein:
Function:
Can convert Man(9)GlcNAc(2) and Man(8)GlcNAc(2) into N-glycans with a terminal alpha-1,6-linked Man residue in the C-branch. Functions in the formation of unique N-glycan structures that are specifically recognized by components of the endoplasmic reticulum-associated degradation (ERAD) machinery, which leads to the degradation of misfolded glycoproteins. Most likely generates N-glycan signal on misfolded glycoproteins that is subsequently recognized by OS9. Required for ERAD of the heavily glycosylated and misfolded BRI1 variants BRI1-5 and BRI1-9. Does not seem to play role in N-glycan processing of correctly folded proteins destined for secretion.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MSCPIHPRRLFLCLLISLTFFVVDPSSQHIEVKKKQMREKVREMFYHAYDNYMTYAFPHDELKPLTKSFTDSLSELGNLKLEHLPTDYNGSAVTLVESLSSLAILGNSTEFEKGVLWLSENLTFDIDARVNLFECNIRVLGGLISAHLLAIDPNNRLIQGSYNNQLLRLAEDLGKRFLPAFETPTGLPYAWINLKNGVMENETTETSTSGCGSLVLEMGALSRLTGDPRFESAALRALRQLWRMRSSLDLLGTTLDVVTGEWIEYSSSIGAGVDSFYEYLLKAYILFGKEDYWRMFHSAYLASQKYFRHGPWYHEANMWSGKPTYWQLTSLQAFWPGLQVLVGDIAAANSSHREFFHVWEKFGVLPERYLLDHQIIHPTMKYYPLRPELAESTFYLYQATKDPWYLDVGESMVKSLNLYTKVPGGFASVRDVTTMQLEDHQHSFFLAETCKYLYLLFDDSFVAKRNYIFTTEGHPIQVVSSWHEKLPETYFSGNWTLSKSGAWESRASALSLQVCPLISLNSRHPEQQRESACHVLDEQINHKCWSNKECGVDATTCRLRTCSGVGYCGLWNPL
The following text describes a protein:
Function:
Member of the three-protein two-component system HK1/HK2/TcrA. Kinase that binds ATP and catalyzes the transfer of a phosphoryl group from ATP to HK2.
Miscellaneous:
MISCELLANEOUS: HK1 and HK2 are merged into a single protein with a distinct N-terminal sequence in strain CDC 1551 / Oshkosh.
Sequence:
MPITPLLHESVARFAATGADITTRAEPDLFVSIDPDHLRRILTAVLDNAITHGDGEIAVTAHARDGAVDIGVRDHGPGFADHFLPVAFDRFTRADTARGGRGSGLGLAIVAALTTTHGGHANATNHPDGGAELRITLPTPRPPFHEELPRITSSDTKDPNREHDTSDQ
The following text describes a protein:
Function:
Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MRRPPPLGPTTASGPEGNVRNLRKRQAPGPGAAGGCGPEAGGRGENRQKRRMVARATPGRGEVKSDKSVAASGAGKAARRRVEGRRGQVSPSDRRGLEAAKEAEFPLQTERHTKEKRKVTEASTDDPQPGFDLVRKESLTSSESFQTVECLRSLGKEGIVEGIKRRIRNKKLKSLENPPLKITENEATQNIKVEFQDELYKNTLKYSCNILSPEVENNFVFKLRDCNCFPHSKDCNDENNLPYEPDGGCMHVAENFSKKENFRSLAEKSDTNNIPQLLQTEENVMGVNKLLPEESDLYQSKINGLLPCLQREKNKYSIEESSVGRKPRKRMKLSEKADETVTQMNFSNEYNKSELMLQENQMIADGKEAEAKSPLNVLRKVSHNTVSLMDHLLSVPEMVEKETSSEHHVNAVFQKTIEPLLKEETENASEPLGYENMALKEDFKSKSCIGKSPEYHIERRSSREDLRSDSEELKLSCQRTIPMTGKRTWPYYSCARISAWCWKKASLPESSYFLPGSQKSCKKVDVPKHQTNKTHLTDSKLLLQSSLTETNTESSSKEKLDSNLNCLFSVSAVEHTLMVIKEPIIKDDKKIKSEELSRSGSEVISNTTEDTQLTSDTQSLTGNKKRDRGNLTKLNLTAASKDGQEANNSTGKTIHRKACVAKQTFVVPDLVKILNTGRLTNFKIPLLKNKTKKRKEVNAKSSEREAYSPLELLDNLSGADTRQNRSKENVSMTMLGPQTLSIQNSVTPVQASSDSFYNKNSCSISPSFTKHGNSSKPSNHFSEPGNIVSNKEVASLTVENNAFSSDPGYVEKSPSFCCNKQETFRPVSSEVRGRKITKNFSEVGFPDILKAYEDDVLLIDVIQDDPDLFGVSNEGELSFTSEVPRISQEPNVPGEHQLTDSKYVETPVKKEPSDDLRELPVLDCGPIKPDICASNSAASEIRHDPKDANTSLGEVANETSENETLGDFSEQIKGSDLDEKHRFTDKVITKEEKENIYEVRKSKDSRNADIMVGECQFAAPVPKPLCLLVPPLNLSGHQEDTILNTWMNDFRFLGKHSVLKLQNPETCEIFKREKNVGVFQKSLGLMIPYKYCKFHFNTLRGCERPLCKFAHVPEQGDEKVCMDVFKKYININELCLLQRAVNVFMEYYRKFPPGIYFDLQVLNDLLNSLLKHCLLKEVFQIVNLSIMVKMLPSLKILLNIFEHVATMKLRNAVPALIDIFCKLVEAGMVLDPEHFNYIVKLLYQVQASKQEITAVLEMKSRLQMRQFKKNWKCDLDSALNKLEHCKEKGDWTKLGKLYINVKMGCEKFADFQTFCACIAETLTKNCEDERPDTPFCEFAETVSKDPQNSKVDKGVLGRIGISAMYFYHKLLQWSKGRKVLDKLYELKIHFASLKGLIGPEKLASRCQIVNVAAEIFLKSGSLDGALWVMRESEWIIDTPLWPCDRLDVLNRHNLLCTIAHETLAKSLYRQTFEVLQNLPGFQNSQETVEVSQYSLLFNKLLGSCIESNSLGMSSSVAEFMISKSIPIDFSFLRRLITSLGRSRLWLKARAHYKSALSLGCYPPLEGNLYRKLLLIPSYLSEIEMLLAIEIFMVSNASSIQSPGTSTQILQIVLKRCEDNQSRSNDDYQAAVERLIMAARISDPKLFVKHMTVNVNKEQVYSLEHCSALKWLKENMKWAGKVWLFSNH
The following text describes a protein:
Function:
Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Subcellular Localization:
Fimbrium.
Sequence:
MNKVTKTAIAGLLALFAGNAAATDGEIVFDGEILKSACEINDSDKKIEVALGHYNAEQFRNIGERSPKIPFTIPLVNCPMTGWEHDNGNVEASFRLWLETRDNGTVPNFPNLAKVGSFAGIAATGVGIRIDDAESGNIMPLNAMGNDNTVYQIPAESNGIVNVDLIAYYVSTVVPSEITPGEADAIVNVTLDYR
The following text describes a protein:
Function:
Myotropic peptides that enhance both the frequency and amplitude of spontaneous hindgut contractions.
Subcellular Localization:
Secreted.
Sequence:
MTAQMFTIALLLSLSAIAAAGTIKTAPARTPSTQDDASFPPDGAPVKRFDAFTTGFGHSKRNFDEIDRSGFGFAKKNFDEIDRSGFGFNKRNFDEIDRSGFGFNKRNFDEIDRSGFGFNKRNFDEIDRSGFGFNKRNFDEIDRSGFGFNKRNFDEIDRSGFGFNKRNFDEIDRSGFGFNKRNFDEIDRSGFGFVKRVYVPRYIANLYKRNFDEIDRSGFGFNKRNFDEIDRTGFGFHKRDYDVFPDKRNFDEIDRSGFGFVRRNVE
The following text describes a protein:
Function:
Required for selective autophagy activation by ubiquitinated proteins. Implicated in sigma rhabdovirus multiplication and necessary for male fertility. Involved in activating transcription of Drs.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere. Cytoplasmic vesicle, autophagosome. Nucleus.
Sequence:
MSMTVKAYLIGKEDCNKEIRRFAVDQDVSTSFEYLQRKVLDVFVGLRTAPFQMYYKDEDGDMIAFSSDDELMMGLALVKDDTFRLFIKQRKEHKRDSSPHGIPGFPFTTPHFSPPGPCHMGPSPMGPPGPPHMGGPPHHPHPMVHPGVTCDGCDGPVAGTRYKCTVCPDYDLCPTCQSKGLHKEHALLPIFHPMANVFEWLPRGKFWRKMRHCMWANAQAQAQNQPQPGPSGAQQNQDAPENPNENGATASSQANVEYLKNIGEEVAAMLSPLGIDVDIDVEHEGKRTKVTPTPPASSGPSSARSDSGSVGLLSRGSGPGSQATEESVSEGTKKDQCSDEEWTHLSAKEVDPSTGELQSLRLEQDGADLPAPLNTASGTSTRDGPTGLREAALYPHLPQDADPRLVESLSQMLSMGFTDEGGWLTRLLHTKNYDIGGALDTIQYSKTPGQQK
The following text describes a protein:
Function:
Sphingolipid-delta-4-desaturase required for the biosynthesis of delta-4-unsaturated sphingolipids and derivatives.
Subcellular Localization:
Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein.
Sequence:
MTVYEEKKGKTILKEENLLSGEKIRGRRREKRKKENTDKRFVEREREMGRGERREEEKEGVVMANDFFWSYTDEPHASRRRQILSQYPQIKELFGPDPLAFLKISVVVLLQLWTATSLRDAGWLKILAVAYFFGSFLNHNLFLAIHELSHNLAFSTPVYNRWLGIFANLPIGVPMSVTFQKYHLEHHRFQGVDGMDMDVPSYTEAHLVTNVVTKAIWVIFQLFFYALRPVFLKPKPPGYWEFINLFVQIGLDATLVYFCGWKSFAYLILSTFVGGGMHPMAGHFISEHYVFKPDQETYSYYGPLNLLTWSVGYHNEHHDFPRIPGNKLHKVKKIAPEYYEGLESYKSWSQVIYMYVMDRTVGPFSRMKRKLSKKSE
The following text describes a protein:
Function:
Member of the two-component regulatory system DpiA/DpiB, which is essential for expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. Could be involved in response to both the presence of citrate and external redox conditions. Functions as a sensor kinase that phosphorylates DpiA in the presence of citrate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The periplasmic domain binds citrate with high affinity. The C-terminal cytoplasmic domain senses reduced conditions using a single Cys in vitro.
Sequence:
MLQLNENKQFAFFQRLAFPLRIFLLILVFSIFVIAALAQYFTASFEDYLTLHVRDMAMNQAKIIASNDSVISAVKTRDYKRLATIANKLQRDTDFDYVVIGDRHSIRLYHPNPEKIGYPMQFTKQGALEKGESYFITGKGSMGMAMRAKTPIFDDDGKVIGVVSIGYLVSKIDSWRAEFLLPMAGVFVVLLGILMLLSWFLAAHIRRQMMGMEPKQIARVVRQQEALFSSVYEGLIAVDPHGYITAINRNARKMLGLSSPGRQWLGKPIVEVVRPADFFTEQIDEKRQDVVANFNGLSVIANREAIRSGDDLLGAIISFRSKDEISTLNAQLTQIKQYVESLRTLRHEHLNWMSTLNGLLQMKEYDRVLAMVQGESQAQQQLIDSLREAFADRQVAGLLFGKVQRARELGLKMIIVPGSQLSQLPPGLDSTEFAAIVGNLLDNAFEASLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRADEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIYIPKVKPNDSSINPIDR
The following text describes a protein:
Function:
May act as a bridging protein that binds pectin and other cell wall polysaccharides. Probably involved in maintaining esterification of pectins (By similarity). May be involved in the specific O-acetylation of cell wall polymers (By similarity).
Miscellaneous:
MISCELLANEOUS: Contains 2 motifs that are conserved in esterases, but it is unlikely that this protein belongs to the catalytically active pectin esterases.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MVQIVPHVANAHMVKTSRKGLLALVVVGVEECCPTRRCDLRDPNLVVDSNCLLSRSTHQSSLVEDSIIINHFRILNFNNRASIFLCLRIGVICSTQSKMYGGKSYILKGSVSLSLIILILLVTTLLVSAKNQPRISLIEVKTCNLAKGEWVEDKKRPLYSGFECKQWLSNIFSCRVMGRPDFSFEGYRWQPEGCNIPEFNRVNFLRRMQNKTIAFIGDSLGREQFQSLMCMATGGKESPEVQNVGSEYGLVIPKGAPRPGGWAYRFPTTNTTVLSYWSASLTDLVPMNNTDPPHLIAMHLDRPPAFIRNYLHRFHVLVLNTGHHWSRDKIEKNHWVMHVNGTRVEGGYFKNVENAKIFTIHSLVKWLDAQLPLHPRLKAFFTTISPRHEKCNNTIPLSRGSKITGEGGSLDTIVESAVNGTRVKILDITALSKLRDEAHIAGCKLKPKKASNVTSAPTFNDCLHWCLPGIPDTWNELLIAQL
The following text describes a protein:
Function:
Transcriptional activator of the copZA operon.
Miscellaneous:
MISCELLANEOUS: Binds a DNA inverted repeat of copZA operon.
Sequence:
MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCSNYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMNQNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS
The following text describes a protein:
Function:
NADP-dependent, medium-chain alcohol dehydrogenase with a broad substrate specificity. Aldehydes exhibited 50-12000 times higher catalytic efficiency than the corresponding alcohols, therefore the major function of the enzyme is as an aldehyde reductase. The enzyme is active towards aromatic and aliphatic (linear and branched-chain) aldehydes. The enzyme is very active towards aromatic aldehydes, such as cinnamaldehyde, benzaldehyde and substituted benzaldehydes, such as veratraldehyde and panisaldehyde. It exhibits low activity towards substituted cinnamaldehydes, such as coniferaldehyde and sinapaldehyde. The enzyme has no activity with ketones, such as acetone or cyclohexanone. For the reverse reaction, linear and branched-chain primary alcohols are substrates, whereas very low activity is found with secondary alcohols, such as butan-2-ol. The enzyme may be physiologically involved in several steps of the lignin degradation pathway, initiated by other microorganisms, in the synthesis of fusel alcohols, products derived from the aminoacidic metabolism, and in the homeostasis of NADP(H). Has the ability to reduce 5-hydroxymethyl furfural (HMF), a furan derivative which is formed during the hydrolysis of lignocellulosic materials, to 5-hydroxymethylfurfuryl alcohol, thereby alleviating the inhibition of the fermentation of lignocellulose hydrolysates by HMF during fuel ethanol production. Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins.
Miscellaneous:
MISCELLANEOUS: Present with 21700 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSYPEKFEGIAIQSHEDWKNPKKTKYDPKPFYDHDIDIKIEACGVCGSDIHCAAGHWGNMKMPLVVGHEIVGKVVKLGPKSNSGLKVGQRVGVGAQVFSCLECDRCKNDNEPYCTKFVTTYSQPYEDGYVSQGGYANYVRVHEHFVVPIPENIPSHLAAPLLCGGLTVYSPLVRNGCGPGKKVGIVGLGGIGSMGTLISKAMGAETYVISRSSRKREDAMKMGADHYIATLEEGDWGEKYFDTFDLIVVCASSLTDIDFNIMPKAMKVGGRIVSISIPEQHEMLSLKPYGLKAVSISYSALGSIKELNQLLKLVSEKDIKIWVETLPVGEAGVHEAFERMEKGDVRYRFTLVGYDKEFSD
The following text describes a protein:
Function:
Metalloendopeptidase which participates in the breakdown of the egg envelope at the time of hatching. Cleaves the N-terminal regions of the zona pellucia glycoproteins ZP2 and ZP3, where it specifically recognizes the peptide sequences TVQQS-|-DYLIK (major site) and KLMLK-|-APEPF (minor site).
Subcellular Localization:
Secreted.
Sequence:
MDIRASLSILLLLFGLSQASPLREFEAIFVSEPETVDITTQILETNKGSSEVLFEGDVVLPKNRNALICEDKSCFWKKNANNIVEVPYVVSGEFSINDKSVIANAISIFHAQTCIRFVPRSIQADYLSIENKDGCYSAIGRTGGKQVVSLNRKGCVYSGIAQHELNHALGFYHEQSRSDRDQYVRINWNNISPGMAYNFLKQKTNNQNTPYDYGSLMHYGKTAFAIQPGLETITPIPDENVQIGQRQGLSKIDILRINKLYGC
The following text describes a protein:
Function:
Involved in epigenetic gene silencing. Methylates specific cytosine residues in the retrotransposons DIRS-1 and Skipper.
Subcellular Localization:
Nucleus.
Sequence:
MEQLRVLEFYSGIGGMHYGLQESGVDFQVIQSFDINTNANLNYKYTFNEDSSQKSIESYSVEELEGFKANAWLMSPPCQPFTRLGLQKDDQDNRTNSFFHLLDVLTKIKDPPTYILIENVFGFAKKGSSNTRDHLLDTLIKMNYSFQEFHLSPQQFGLANQRLRYFCIAKRNGKLNFKKEQDKHNEKVDENKLNNNSNNNNEQNKYDNLKILDHIPGYDFHTTLEECDEISNYFDKDLTDDELYEKYKVPHNLLLSKGMLFDIKQKDSKTSNCVTKSYGKFIEGTGSIIQMDNNFKADINDNKSLIPLKLRYFSPKEITRLHGFPEEFKFSPKLTTIQCYRLIGNSLNVKIVSELLKVLVSPNEEEEQQEQQKEKEGKK
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular Localization:
Cytoplasm.
Sequence:
MATKDTASADPTAAAASPEPTAPSSTQQRKARFRLDACKRCREATPHVLLQKDLPYCRDCCIYNVHRKSRSELGKNRMIRQFERIALAFSGGNRSTALLGIIRRHMTKGEHRQLRIVPTVIHIDDGCLFGATQAEHERRAERIQSLANALDYEEVHVLRLEELYRADDEPDLTAAAARVCALFADLSTVTARQDFLRTMKARLLRAATQQLDCHKLMVGDCHDQIAMRILVQTTQGRGGNMTRFSTFCDEVDGTAMLRPLRAISARELGYYNHFRRLEPVLYPTVGARAPEKTSFESLIQAFVANLTVDFPSTTAAIYRTSEKIAAIDRPDAPDCRLCGLPTDPATTSIAQITAKDGHLNIRDRLTVDGQDLTDCLCQGCRGTLLDASQQTVGLPPTLRANTVAPPQSITVATAIIMAGKLPSEVHYYASVINCPAYANNAAYKAVLAPVVGTAASLLPAFQSPVPRGEDYRSLRLQQDQQLSLQLTKSGVSHQRAGDHDKALSLYHRALQLSEHNVEALVAKGTLHTILQQYDRAVDCLKTALRLQPEHVNGRRYLETTYFRRGKYLEDCGKYVDAAEDYSAALELHGPEEAKAQQMLQSVHNYLVKRAAQSEAADTAARASFGKLSPSTASHGTTGRSSSELLSVMHKMLEEDRDERRRHKKHKKLKKKHKSSGRSDRGDRSPKRSRHRGGSSDESSDAEGESR
The following text describes a protein:
Function:
Actin-bundling protein.
Subcellular Localization:
Cytoplasm.
Sequence:
MLDGDRNKDGKISFDEFVYVIKEGTVGTRWITIKTATLPRNHLVIFQEVKSSDIAKTFRKAINRKEGICALGGTSELSSEGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFKAVGDGIVLCKMINLSVPDTIDERAINKKKLTPFIIQENLNLALNSASAIGCHVVNIGAEDLRAGKPHLVLGLLWQIIKIGLFADIELSRNEALAALLRDGETLEELMKLSPEELLLRWANFHLENSGWQKINNFSADIKDSKAYFHLLNQIAPKGQKEGEPRIDINMSGFNETDDLKRAESMLQQADKLGCRQFVTPADVVSGNPKLNLAFVANLFNKYPALTKPENQDIDWTLLEGETREERTFRNWMNSLGVNPHVNHLYADLQDALVILQLYERIKVPVDWSKVNKPPYPKLGANMKKLENCNYAVELGKHPAKFSLVGIGGQDLNDGNQTLTLALVWQLMRRYTLNVLEDLGDGQKANDDIIVNWVNRTLSEAGKSTSIQSFKDKTISSSLAVVDLIDAIQPGCINYDLVKSGNLSEDDKHNNAKYAVSMARRIGARVYALPEDLVEVKPKMVMTVFACLMGRGMKRV