lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Required for efficient export of polyadenylated RNA and spliced mRNA. The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Required for NXF1 localization to the nuclear rim. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Plays a role for proper neuronal development.
Subcellular Localization:
Nucleus. Nucleus speckle. Cytoplasm.
Sequence:
MAAAAVVVPAEWIKNWEKSGRGEFLHLCRILSENKSHDSSTYRDFQQALYELSYHVIKGNLKHEQASNVLNDISEFREDMPSILADVFCILDIETNCLEEKSKRDYFTQLVLACLYLVSDTVLKERLDPETLESLGLIKQSQQFNQKSVKIKTKLFYKQQKFNLLREENEGYAKLIAELGQDLSGSITSDLILENIKSLIGCFNLDPNRVLDVILEVFECRPEHDDFFISLLESYMSMCEPQTLCHILGFKFKFYQEPNGETPSSLYRVAAVLLQFNLIDLDDLYVHLLPADNCIMDEHKREIAEAKQIVRKLTMVVLSSEKMDDREKEKEKEEEKVEKPPDNQKLGLLEALLKIGDWQHAQNIMDQMPPYYAASHKLIALAICKLIHITIEPLYRRVGVPKGAKGSPVNALQNKRAPKQAESFEDLRRDVFNMFCYLGPHLSHDPILFAKVVRIGKSFMKEFQSDGSKQEDKEKTEVILSCLLSITDQVLLPSLSLMDCNACMSEELWGMFKTFPYQHRYRLYGQWKNETYNSHPLLVKVKAQTIDRAKYIMKRLTKENVKPSGRQIGKLSHSNPTILFDYILSQIQKYDNLIIPVVDSLKYLTSLNYDVLAYCIIEALANPEKERMKHDDTTISSWLQSLASFCGAVFRKYPIDLAGLLQYVANQLKAGKSFDLLILKEVVQKMAGIEITEEMTMEQLEAMTGGEQLKAEGGYFGQIRNTKKSSQRLKDALLDHDLALPLCLLMAQQRNGVIFQEGGEKHLKLVGKLYDQCHDTLVQFGGFLASNLSTEDYIKRVPSIDVLCNEFHTPHDAAFFLSRPMYAHHISSKYDELKKSEKGSKQQHKVHKYITSCEMVMAPVHEAVVSLHVSKVWDDISPQFYATFWSLTMYDLAVPHTSYEREVNKLKVQMKAIDDNQEMPPNKKKKEKERCTALQDKLLEEEKKQMEHVQRVLQRLKLEKDNWLLAKSTKNETITKFLQLCIFPRCIFSAIDAVYCARFVELVHQQKTPNFSTLLCYDRVFSDIIYTVASCTENEASRYGRFLCCMLETVTRWHSDRATYEKECGNYPGFLTILRATGFDGGNKADQLDYENFRHVVHKWHYKLTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNLGQALERRVHKICQEEKEKRPDLYALAMGYSGQLKSRKSYMIPENEFHHKDPSPRNAVASVQNGPGCGPSPSSTGSTSKSDESSAEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARILGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKVKDEKFKTTVPNAESKSSQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNSDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKQYPFHLDVFSQYNGKL
The following text describes a protein:
Function:
Leucine-rich repeat protein that likely mediates protein interactions, possibly in the context of signal transduction.
Sequence:
MRDMAERRSRHGHGHANVVPFGAGAGGGLQHGEHDQEKVKEKKLDMSGLSMDTIPHLTMSLGHITTLDLSNNNLESIPESMIARLLKVVVLDVRSNQLKSLPNSIGCLSKLRVLNVSGNLLQSLPATIEECRALEELNANFNQLTRLPDTLGFELHSLRRLSVNSNKLTSLPFSTSHMTALRALDARLNCIRALPEGLENLVNLEVLNVSQNFHFLRELPYGLGLLTSLRELDISYNSISVLPDSMGCLAKLNKFSAVGNPLVCPPMDIVEQSLDAMRTYLSSRMNGTGVNAKKKKGWLPRMVKYNTFSARMTPGRKSAHDNSEGFSMSDYHSLNGSASPGFLSMLSPRRLFSPRRDSPKHH
The following text describes a protein:
Function:
Probable ATP-dependent RNA helicase.
Sequence:
MVENISLNVTVKSSARKNQQQSPALSVKKRAQKSQDFDFQFNVDKPKVKAIVVRRRAPPSKVEPTNSSVPNTTKSPTPSVSSSKSAISTLSASPKANASNDDLMFNVSPTKPPVKSVLGDDFMLNVTTKPVVAQKAKPKITRAERLGKKQRQGKPLTKLSEEQITRALKSNKKPKNPNQLPTPGDLFRAQLEEERRQKRREEGGGDQEASADEEDAKNNSGGGSPRVKPSSAVKESKKSSDIEDSGESGEESATSDEEPDESSAQSPGQEKEPKQTAKKPPKAEETSSTNRFRTKKIGLFDQSDVEALKQLGQRAVKPVKETIFTGSKISTLGLHPHAVKNLEDLLSIRELTSVQQKTIPEVLQGKDVLVRSQTGSGKTLAYALPLVELLQKQQPRIQRKDGVLALVIVPTRELVMQTYELIQKLVKPYTWIVPGSLLGGESRKSEKARLRKGINILIGTPGRLVDHLLHTASFKLTKLQFLILDEADRLLELGYERDVKQLVEAIDKQRAECEDKELPQLQRMLLSATLTSQVQQLAGLTLKNPLYIDNSDEAASAALKSKDGYQKETIEALLEVDDGLGEYQEDVTGVLSIPENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQFKAIVFMSTTEMVNFHHDMLNEALTRRVLDEEDEQEKGDSDDDGDIPLLQGLRFFKLHGSMTQTERQGVFRGFRDCASCVLLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTARAGRKGRAVLFLTPSEAQFVRHLEKKRIRIQQGDMYAYLQTLLPKDDEARTVQEAASNLQHKFQTLLEDDRELHDKSCKAFVSWMKFYSTFPKELKPIFNVRIAHMGHFAKSFALKEAPSKFAAKHAAPKAAPPTNRLTYTERDPEKIQAQKRAKRRFTTTVSGEVRQLQQRDVGAQKPGAPPPKGGFIGGGVGRSSFMKSLGKSRALNMSEFDSGLPPEGAAKRRKQA
The following text describes a protein:
Function:
Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MAKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEGRASLYKSVVSNSCKEMSCYSDFPFPEDYPNYVPNSQFLEYLKMYANHFDLLKHIQFKSKVCSVTKCSDFAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFPGINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQNMLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIRPSIKEVKENSVIFNNTSKEEPIDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPPPSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLFSMLLMDPHLALIVFFGPCSPYQFRLTGPGKWEGARNAIMTQWDRTFKVIKARVVQESPSPFESFLKVFSFLALLVAIFLIFL
The following text describes a protein:
Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAFFSSSSSSFPVVFARMEEASSSTGSTGGAMAGIPVIPSTSAALLANTNLEPERIAVLQTQLQEYRQKQMDLIGHFQRAQQELSVQHMHNLYTALQQQQQLQSLQERSGINPMLISQTSEDATSGPAAPLSLANSLTNLLSSSNGNLSNLSVPQTPTKEHHPTLPPQQPSAPTSSRKSDLPRTNSTTISQLTKDRLKNMIANRSKGESNSQSNLMSNVNGHDNSRRLKNSNSQMNVSSPHFEPYRLPTSLANAHNLQQASEFQLRKVNSEPNLKMKIRAKLLSKGNSPVQHVQQTNNSQFSFTHPQLKRSDSETSNMPIDMLPSGSHSNIPHLMLPSPSLPNLAAATGAFQNLNLPIGQDLTAFMAVANLSPFLSLPSLLNKKLELGGMTDEGDRNGFSSSASNSSLASNASLGSHQYQSLLKQQIRDLVLRRKSLVREDPEGEGMAESYNGLFSHAKLQQLTALAMESGFNPKLEPTFSTGLGYDPLMARHECVCSNNSNHVENGERIQRIWSKLTEEGHVAKCERITAKKASLEQLQMVHSQTYTTFFAVSPTACLKIDANALPLKRFLQLPCGGIGIDSDTYFNDASTQIAARLAAGTLIELSSQVAEGRLKNGFACIRPPGHHAEAEQALGFCFFNNVAVTAKVLQAKYPVQCAKIAIIDWDVHHGNGTQLSFDDDPNVLYMSLHRHDNGNFFPGTGSVTEIGKGAGKGFSVNIPFSGGVMKDAEYLAAWRTVVEPVLASFCPDFILVSAGFDACHGHVNALGGYEITPEMFGYMTKCLLSYANGKVVLALEGGYNLDSISAAAEQCVQALIGESDDAGRLCTDSLENLPNQSALETLQKVIAIHKGFWPALHGQEAAINTTEMQWRNVKLQVQMQQQQQLQQQLQQ
The following text describes a protein:
Function:
Mediates homophilic cell-cell adhesion.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MYGKSPTRAVLFLLGLQLTALWPTAAVEIYTPRVLEAVNGTDVRLKCTFSSFAPVGDALTVTWNFRPRDGGPEQFVFYYHVDPFKPMSGRFKDRVAWDGNPERYDVSILLWKLQFDDNGTYTCQVKNPPDVDGLIGEIQLSVVQTVRFSEIHFLALAIGSACALMVIIVIVVVLFQHFRKKRRAERAHRVVEIKSKEEEKLNQEKKASVSLEYTD
The following text describes a protein:
Function:
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Sequence:
MNHFDYRNGVLHAEAVNLSELAATVGTPFYCYSTATLERHYRVFADAFAGEKVLVCYAMKANSNQSVLRTLARLGAGADVVSGGELKRALAAGIPARKILFSGVGKTEDELRAALAADILCLNVESEPELELLSRLATEMGKTARISVRVNPDVDAGTHAKISTGKSENKFGIPIAHAREVYARAAKLPGIQVTGTDVHIGSQITDLSKMETAFRILSEFVQTLRADGHDISHVDFGGGLGIPYYMDREAPPAPDAYAAMVKRVSHNLGCTLMFEPGRMIVGNAGILVAKVIYVKHGDGKNFVIIDAAMNDLIRPTLYEAHHDILPVTQPARDAATMVADVVGPVCETGDYLALDRTLPTPKAGDLLAIMTAGAYGAVQAGTYNTRPLVPEVLVKDDQYAVVRPRIDVEQLIAMDTPAPWL
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MVCILKYIYNIIIVFIYFFVLGCFASNWKYTGNSGPQFWEENSPKCGENKQSPINIETKSVLPDKQLSQLQFTGYNQNLTGGMLINNGHSAQLNFPAGKSFQLLSSVNSEIYLALQLHFHWTSKNVSTLGGSEHSVDGEFYDAEMHIVHIKQPYGSLDEIKSQPDGLAVIGVLIRATDQQNNDIQKLLDVAQLCEYAGDTHILEDGPELINLLPSSVSYYRYHGSLTTPPCYETVQWTVYKEPIYISHQQLKKMFSIF
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MDLLERSAATIKAEQQGEAQRKEAERKEQEQEQQGQGLTGRHPLANGRSGMLPMSSPPANPGQLTIFYGGSVCVYDSVPPEKAQAIMLIAAAAAAASKSNGTAAVKPPAMSATNAIQAMLTRSLSLQSTSVANGQPQAVADPGSICKLQADLPIARRHSLQRFLEKRRDRVVSKAPYGAGKPSEGMGASSGMEAVAEGKAQ
The following text describes a protein:
Function:
Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9', 'Lys-23' and 'Lys-27' (H3K9me2, H3K23me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress-induced longevity.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates binding to H3K4me3.
Sequence:
MDGNDINIQKNEFSRDQSALLMMDQHSDHKNHESAIGEPGMSYTASQPALSSTEHQTPLVSEASVAAPQNHLNGNSHESVSEMDRNSVDFAIESVLMKARAYNKMGAPKDPRRKQHNPKSEPKIEPHVTDSSDNQAAMSNKMEAEAPKMESNQNYVSNGSEPPFRFVSISNFDEMKTKKKEVQEELKLEVDSDSEEDDVPEQKTPKESDRCGGCGKFTHEDDLIALEEEKKKEKEKPLMSKKKSHHHKKNDFQWIGCDSCQTWYHFLCSGLEQFEYYLYEKFFCPKCVPHTGHSIRYKVVAPHRYRWYSPNEKHLGIEVGSKTWIEDFITRENTVPSPTDDEVCIVEDGYEFRREFEKLGGADNWGKVFMVKDMDGLNMTMPKPGFDLEDVVKIMGSDYEVDTIDVYNQSTYSMKLDTFRKLFRDTKNRPLLYNFLSLEFSDNNEMKEIAKPPRFVQEISMVNRLWPDVSGAEYIKLLQREEYLPEDQRPKVEQFCLAGMAGSYTDFHVDFGGSSVYYHILKGEKIFYIAAPTEQNFAAYQAHETSPDTTTWFGDIANGAVKRVVIKEGQTLLIPAGWIHAVLTPVDSLVFGGNFLHLGNLEMQMRVYHLENAIRKEIRSEEKFYFPNFELLHWMYMRNVLLEKITEANQEGSDMREQEKNIWTASQIMKAEMERWMDRELRLGPEKNAILPTDDKNKIMISVRKQIEIQTKIQNAKNKPMGLKQKRKSRESAERDDEDYCPSSSTAYKKKYTKKAKKDNDDAPKVKKAKKEEVPEEKVPVPEAAGPSEVTAPLTIKIGMGPTEDQKGVVQIFNNQCTSSGRKVKLNQNVADYCGSHLEARVEEIPEKATKSFRELDNELERCEAVHSGEKIKKVKEPKPPKQPKEKKEKPPPKKKEMSSRDRLMKKLKM
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Nucleus.
Sequence:
MSVEEVDTLLQGVVTCGTNADEVALEKLREIPLLQLSRMMGKYLTGEEHVVNAVRVLGLATVNRRDRTIEEVDVMLRFFSRKLSSMQTIAVAVESTALLVRELSSEGPCTSDVFNVLHTEFLQSFSLQALPTNVRSWGYDVLRFTVTKETATWFTTPFLQVVLKSMDEENEPELLMRALELHHIIASYAREDAMQPLLEEYFDSISSYFPVVFSQPPGCKVSKEDLRRVLSACMTHPLYLNICVPFLLSRMASPSSVVKQESTNALLNIFSLDSSHTTESLCPHVVSVTNHIRNEVVRAVSLGSGECEPYVKDCVHVLKFISKRAQDVSLSIVRSWLEPMTSGALASLRSGPAVCSAYATMFYHLVSSSTCCGAATVQCFLLQLLSNTREDSFEVDDAVLIISAILSGIFDAGNGGECGKRPPPQRDVKEGLETVSEKLFQLVEKLTLSLQKADASSVHVRCELLASLVTLAAWLPHWMPDDTVLLIYKRLIALCLCGDEEVGNRVVKHISRIGSVEGNLLNVALLDMPADINPTAAGILTLYKGLLGSQASLSLAATKSLLECPEGLFGFTLTERDVFSLCRSSLSAHADYSTEDIRCLLLLTKKRNSVASFDYLCDLLLLLPIAFVPSVLQEVGGEQWGVLTASLVSCFDMDVLGASDHIEHWMCEVLDAMRSTPTDVLTMQSVSLLCARVPGVAGRFLEAAKRLNPTTQLAARAAVARGLLACGVAEGGIIELIIEEITNSLRSGYVQDCYVDILTGVFVFCYQGCRKTTTLILPLVHAATRGSKPVSLELLRVVAKLLQDVSPTCGLEWGDIVEFSRRVSKPLNEEFVNELVELLDLALSQMDPKNVLVEALLGTDDLLPLVLSGVRSPLLKVRCTSLRLLSEAALFVMQFSSENGDSGNSYMSSALQVRDEVLHVSQVALNDHKRMVRRSAAQCRHQWYKLK
The following text describes a protein:
Function:
As component of a spoke-associated complex, regulates flagellar dynein activity by mediating regulatory signals between the radial spokes and dynein arms.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MAEEQTALSLSWVFGASAHVKHGVVNLSDGYTDKICYLAANTAVIYDKRLRRQLFLQGHTSPITCIVTTEDRSHVVTADTGPEALLVVWNVRTGLPTRTVQQPHRHGVSTMDMSADGQWLATVSAADPESGEQEVSLWSMAALLTPPEAAPPGQGPLRPLVTTLVPAGDVQHSIRFSPNNPAELISNGRRRVYFWSWAPGSPRFQYYSPPLRSRDFKQSVGDFVSSVFVPGTTQALTATTDGDLVVWDEQGIAAQVGTSATDRRAIKLMRIHNCPITLLATVGDFIVSGGEDGYVRFFDPLLRIVAWFEDLAAGPVTSVAFSAVLPDRLAHADAADTLNRFMVPDFVVATRNSRIVSVQSASFEEYDADRRRGSSVLDSLLADVVDLAAHPTRAEFAVLGRDGGLQRWDSIAHCLLGGRAFERQVGACLTYSRDGSLLVVGFGSGHLHILNADDCSDLYVMRNTAAGLVRVAVSNTGKHIAAADENHQLLLYAYLPYKHTMRWEYVGRCRSHHGPIASVVFGESPSGQTRLLSVGGDGRVVEYDLAASSVAAGVQVASFYDFPPGGGAPTSLSFAPPLAYFQAFAADTHLLVSGADGTVASWDINTAPLERSATAAEGAGGEARWAAVLGDPDLLREMRDYFVYAQIKTQGEDALEPRDVPGTVPVDLVPDLMRSAGFYPSESDIDNLLHHVQYMAHSRNMESLEVVTLADLLCLYINHRPLFNVTHADIVAAFRELGGRGDPGSCVPKLSREQLLSLLQSTGEPMSGEELTAALAALTGAHTPEKSMPVSVAAEQFSADVLGFDTTEAGAEAAT
The following text describes a protein:
Function:
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular Localization:
Mitochondrion intermembrane space.
Sequence:
MRSRKLYDGDVGYELRGQSSQKFRRKGQVKKQNEIEIEIPNGDLTKGRIFFNHNCAGCHDLDQDLYLGPSLRTVYLRRNGSKKFSNYGKDLTAYKFYWTRKKLWEFLENPEKMFPDTNMQLDGVKDPFMLASVIDYLQYLRVFTCDIRGLKQII
The following text describes a protein:
Function:
Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.
Subcellular Localization:
Vacuole membrane; Single-pass type II membrane protein.
Sequence:
MENIGPNRSSARQYLLITFLITFVVSISTYLYCADYVSYNIWNSVTSKSNKPYISIKTLDLNDTQIDDLKRLGLTPKKSVEIVKPDNSKQTIHGRFLHITDFHIDHHYQKGSDIDKVCHGGEGKASKYGDAILGCDSPPILVEETFKWITDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKEISDKFVTLTSESDGQPLIYPVSNNDIMPHNLMDTGPSLQTRELFEAWRPFIPQVQMHTYLMGAYYFQEVIPNQLAVLSLNTMYWFDSNPMVDDCDNKGDPGYKLFEWLGYVLKEMRARNMKVWLCGHVPPNEKNYDTTCLRKYIAWTHEYRDVIVGGLYGHMNLDHFIPLDSVQAYKSIQKDFKDEFKQKSVFSVEDEDDLALEDSNLYKALDENFSDKFFRVTGGVPNNKVTYLETLREELYAPLKGKKKSGEHFERYSIAHVTASIIPTFNPGMRVWEYNITDLEDKLQQVKFEPWDKFFAGVERMIEVQSNYVDEKDNDEMNWQEMDDITIERKKKHKKKNRKKKKDHTFPKPMPENLPLGPAYIEQTFTPERYVQYYADLESINKGKKEFDYEIEYSTDDSLYGLKALTVEEWIKFGRKLGEPVKDLKNNVNKGKKKKNNGKKYKKLQQIWNAYLKHAFISSDYEHKGYG
The following text describes a protein:
Function:
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
Subcellular Localization:
Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSKSQPKSQMKGLTQFIVDLRNSKDQDEEDKKINLEINNIKTKFNNNNLNGYQKKKYVCKLIYIYLIGNPNLVDFGLKESFQLLQSNIFSEKKLGYIAVATLLDNEKILINGKNQKSKKFTSSKQRLNYILENIHTDLVRDLQSNNEEFNCLAIQFIASVFTINADSDNTIIKESDENSHLWLELVDMVYASVTSPISSPIVKSKASIALKSLLKLYPQVIITNNNWIPRLLKLIDDKDYSTIISSIPLLQFILSLEPQYVKSVMPSIASQLSQIVIEGKCPEPYFYYDSPAPWLIVKLLQLVEQLFLLVDQQGSQVLTIDKLDDNTINQLRQVVAKSIQNASQPIKGLPNRNSQSSILFQAVSLAVFLEASPEAISGAMNALLMLLTSNETNTRYLSLDALIKLTARSNSNYLSSSKDNFDKALNIIMKLLRDKDISVRRKALDLLYTICNFENYNIIISKLLDYFPNADFLLKSELAIKIAVMAEKFATDSTWYVTTMLKLLSIGGGSNSNGVGFMSNEVWERIVQIVVNNESLQKKTCKLLINLLRRPFDQRNVASPSQHQQQQPPPQALPLSESLIKVAAFVLGEFGDQINDIEDLNVIVQFQLLFDAYFKVSLLTRAMLLSTFLKFLVKFPNESFVPDIVDLFEIETQSIDLEIQTRAYEYLKLVTLQSDFKLAQNVIKPFPAFNNKVENPLMNRLGSVSRIVGVNRSRSLVMAKNIKSKPVSRAIPEEEEEVEEFNTTIENDPFNEESATAAATTTTTTTTTTNNNNGSHSLKLSPNWYAGYHRMLHFDAGIFYEDQLIKITYRIMKNTNELTIKFTIINNARKNINKDITGFTILNLESLANIQDPNYTLHIQTLPESTIKDKTQMEIYIKVRNIIENNESPVLSMTYMCGGSFNQLNLKFPVLLLKTITPTTLSTFEEFNKRWNQIGQLLGIEQGQFIHKVILTHRYNSSNISRLLSRVGLAIIKTTDDTLNGPIYVASAGILHTQKSNYGVLITIRGTDEIGKELQIVVRCTGGGVAEVICSTLKEIFTGKF
The following text describes a protein:
Function:
Involved in GDP-fucose import from the cytoplasm into the Golgi lumen.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MKLHEENNKALFEAMRNRENPTKWESYKQVITAVSAYWVFSIGLVFLNKYLLSSVQLDAPLFITWYQCLVTVFLCLFLSKTSKAYGLFKFPSMPIDAKISREVLPLSVVFVAMISFNNLCLKYVGVSFYYVGRSLTTVFNVVCTYLILGQKTSGQAIGCCALIIFGFLLGVDQEGVTGTLSYTGVIFGVLASLSVALNAIYTRKVLSSVGDCLWRLTMYNNLNALVLFLPLMLFNGEFGAVFYFDKLFDTTFWILMTLGGVFGFMMGYVTGWQIQATSPLTHNISGTAKAAAQTVMAVVWYSELKTLLWWTSNFVVLFGSGMYTYVQKRVMDKKNSGASPASEAKSDKVKLLGRDGNAAEESV
The following text describes a protein:
Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida (By similarity).
Subcellular Localization:
[Processed zona pellucida sperm-binding protein 1]: Zona pellucida; Cell membrane; Single-pass type I membrane protein.
Domain:
The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
Sequence:
MTGGRLVALLLLVAASLGLGQQPHPEPGLPGLQYSYDCGMRGMQLVVLPRPGRTIRFKVVDEFGNRFEVNNCSICFHWVSAEPQAPAVFSADYKGCHVLEKEGHSHLTVFIEAMLPDGHVEVAQEAVLICPKPGHTWAVGSHQVPPTTPSPTTPHALPFHLSSAHTFPIPLYLEHSLMLPTPAGPSLGPGPTPAVLAQVERWEVDKPDAVGSHLPQEWCQVASGHIPCIVQSSSKEACEQAGCCYDSAREVPCYYGNTATVQCFRNGYFILVVAQEMALAHRITLANVHLAYAPTRCPPAQKTSAFVIFHVPLTHCGTTVQVLGSQLFYENQLVSDIDVREGPQGSITRDSSFRLLVRCIFNASDFLPIQASIFSPPLPAPVTQAGPLRLELRIARDETFSSFYEEEDYPLVRLLREPVHVEVRLLQRTDPSLVLELHQCWATPSANPVQQPQWPLLSDGCPFKGDSYRTRVLALDRAELPFRSHYQRFTVATFTFLDSGAQRALRGLVYFFCSASACHPSGPETCSSTCSSRTAKRRRSSGYHDGTPRALDIVSSPGPVGFQDSHRQEPTLESTGSGRNSNPKPLLWVVLLLLAIALVLGIGVFVGLSQAWAHKLREGHRLTDQAQ
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MEETMETSMRVIAAWDYETSDISPNTSLFNHHTREEVLEFMRAVTDLHATHQFFSTNNFSYHIHYPLHKKIVSCQNLLRIAKKRLSSEFFSLLKVNSKHNIDYYSVEDGHSPVSSSDSSTSNTNNADLNIFTVSNINYQEDSTTEEASAMADLKLIANCMMAAGFGKKCLKIYKLTRRSFIEDALLKLGARKLTKSHVQKLDWETINAKMTIWLKNVGICVKIFEQEKILCEHLFGACTLSTVTDSCFSEVCKEVALTLFIIPGKLAKHAKKSSDKIFKFLQLYEGMSEDTTSKIDKLFSSELTATVRIQLRSSMGRIAEAVKSMQTDFEASIQKDASKGIVHGGGAHPLTKAVMNYIVHLSNHASALDEILSDFPVSLQSPLPESYFEGETMSSPVTLHFAWLILVLLSKLDSKSELYKDASLSYLFLANNLQYVVTKVKCTKLYNVLGEKWVNKHASKVVQYAANYERMGWGRVISVLPKDLTVEISLDNVKESFKRFNVDFEEEYRKQVDWVVQDPKLREEMKASIIRKVDVRYRKMYDKYKVVLAKSRERGKIDSVVKFTPEDLENYLLDLLDCHEDEEVVSPSEKSETPPSNDKKENPVLQRRSRRLLLLVRQHHNH
The following text describes a protein:
Function:
Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity).
Subcellular Localization:
Nucleus. Note=Binds various differentially methylated regions (DMR).
Domain:
The KRAB domain is required for function as transcriptional repressor; Zinc fingers 3 and 4 mediate recognition of the target element, ZF3 interacting with the 5' half (TGC) and ZF4 interacting with the 3' half (CGC).
Sequence:
MAAGEPRSLLFFQKPVTFEDVAVNFTQEEWDCLDASQRVLYQDVMSETFKNLTSVARIFLHKPELITKLEQEEEQWRETRVLQASQAGPPFFCYTCGKCFSRRSYLYSHQFVHNPKLTNSCSQCGKLFRSPKSLSYHRRMHLGERPFCCTLCDKTYCDASGLSRHRRVHLGYRPHSCSVCGKSFRDQSELKRHQKIHQNQEPVDGNQECTLRIPGTQAEFQTPIARSQRSIQGLLDVNHAPVARSQEPIFRTEGPMAQNQASVLKNQAPVTRTQAPITGTLCQDARSNSHPVKPSRLNVFCCPHCSLTFSKKSYLSRHQKAHLTEPPNYCFHCSKSFSSFSRLVRHQQTHWKQKSYLCPICDLSFGEKEGLMDHWRGYKGKDLCQSSHHKCRVILGQWLGFSHDVPTMAGEEWKHGGDQSPPRIHTPRRRGLREKACKGDKTKEAVSILKHK
The following text describes a protein:
Function:
Involved in mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSYNISLDSLPYFESTYNEEDRSAAAQIVEEELKRSGGLLIKQEEQKKKFQSHRLSDRLENAIVAAGKGEKLAAIDVQRYIQLKPPGTRESLLQSAVVWEYQKSRNDNLYLLEKHGEKAFDSSLEALEVQLELLEKELVNTKKLSQGCNRKRKHYQMEVGARLAEAEVKFGQLLQSSIQCRVATLLS
The following text describes a protein:
Function:
Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs. Required for the correct positioning of the substrate tRNA for methylation. Required to suppress amino acid starvation-induced autophagy. Enhances the STK11/LKB1-induced cell growth suppression activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MKSTACCADCEMASPVESAVVKSAVLVAPITALEFLGEDFLLTGEGPILSVYSLQASPKKCASINVLQNYRIHGIRPYKKHQSGGIPFSGASSASDNSYKGDIIVFGGKGVRLVSFESEGQCLKLIGPLLELQDWVLDIHCFKRQPHSLLGISLAHNAIMLLEAESGNIISFYSCVETCLLYSALMVGPNWDSVVLVGGTVFNQLVLWRPAGTKLSGQSQVERRLLGHSGVIFSLCYLQESGWLASASDDRSVRLWSVGTLGGDAGCGKESPTCLRVLYGHQARVFCVKLTPSRLFSAGEDGACLLWEWGGEGKVGCAFRGHKSGGVRALAVSEGSISCRAGWVATGGADGGVRLWRVAEGKKISEETQEETQLDLGFRGHGCPKVVRLVGEGESNAILVCTDQGEVCLSQGDIWDVIWQGGSEFQSYCVMEVASIQVQNSDCIVQVCAVGNLNGGVQVFLVGQPGVGVFLRAGEGKVHSVLWVKGLFGESGNVCLLASGSEGLVYRWTINVTEDKSGLHIKEEALLPFLLPPCAKRWLTAAVTLSQRNGFCLCGDRRGSLLLYMERENNDRINEGEESRIDSQDQETENRQTELVSSLSPISTLYGVHGKQGVTSVCEYQDLCYSTGRDGSVRILTVEESTLKVRRVHRACKGMDWLEMVLFLGSDGPERMLNKTIVKRTNDTGRESIAEARFVMVGFHSVHFVIWDPHRQEKLLSVTCGGGHRSWAFKRPISTHIDTQTQALRQGTLVFIKQGAVMASRSLMSTDTSVNGHTLKEGLHGRGISCVCHLGSLSGDLSELWEVFVTGGEDTTVGVLAVCPQSGIVKVLAVLTDHISIVRALAAIRRGDMNERERNNGMETSVLSSLVFSAGGRAQLQCYRLLIHLDEQQSQPICQVTQIAGHRLDEQWERKRNRHKTVKMDPETRYMSIAVVQNESEGVLLALGCSDGAVRLFSVNESSRSVDVLWECFYHQRCVLSVATCKLEDSQGRKLLLLFSATTDGCISVWDLTAVLNSKASVSWQGPSVPFFSIPVHQSGVNTLALSPRTEKGQTEDNVISLASGGDDGQLSLLRIKIDQAEQENGVASLQLLSHWSIPLAHSSPLTGLCLLSPALLASTSPDQRMCLWSVESDGLRPLQVRFSHIADAAGLWAWRSEGQEGGAWIVVCGQGLQLFQLTEKEIDEAENGRAEGEERKKVMFSHQCSRT
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.
Sequence:
MTDSLEAQALKSPTSPNRRPEVCGPHAPERPYPIYLRGKVERGFGRGSKDLGCPTANLPSKVVGPGSSLTRTGVYFGFARVLPQDPDDPSLTDSEEVDPSNPSTQVDDDENEVVLGASPIGDGFLGRVQPNAASILEAQATRKDKELDVSRSELNDGVGSLHGATASSSSSSSSLAAARSKKTKRVHLQHEDTQVYPMVMSVGWNPFYKNTHKTAEVHILHDFADDFYGLEIRVVVLGYVRPEYNYDSLDALIEDIEMDKRVTVNSLARPLYQDYSQDPFLGR
The following text describes a protein:
Function:
Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
Subcellular Localization:
Cytoplasm.
Sequence:
MADECRSVLFVCLGNICRSPTSEAILRHLLAQKGLDKQWKLDSAAIGPWHVGKRPDRRGLAIQKREGVPNTHRARQVCEEDFREFGLILAFDDENVQDLEQLRPKDGTAKVELFGKYDPDGVTIIEDPYYGDEDDFEVMYKHCYRCCQEFMKKNCSA
The following text describes a protein:
Function:
Plays a role in promoting the proliferation of synovial fibroblasts in response to pro-inflammatory stimuli.
Subcellular Localization:
Nucleus.
Sequence:
MALHDPARLRKGLWYTSRGKKILPQKQAEAIVQQMHRWTHLGTVTPESVTSGPEDEEEQVELAEEMENEICRVWDMSTDEDVALFLQEFKAPDIFMGVLTRSRCPRLREICVGILGNMACFREICESVSKCEDHGQVLLQCLCDSDPPTLLETCRLLLTCLSQTEVASVWVRRIREHPSVYASVCFIMSSSTNVDLLVKVGEVVDKLFDLDEKLMLEWIRNGAARLPDQSQEDSEEQPVFSIVPCILEAAKQVRSENLEGLDVYMHVLQLLTTVDDGVQAIVQCPDTGKDTWSLLFDLVCHEFCQPDDPPVILQEQKTVLASVFSVLSAISASRAEQEHLKIEEGDLPLIDSLIRVLQNVEHCQKKPENPSESDTEEPTICGSTQDDFHMKILKDISCEFLSNIFQVLTKETVAQGLKEGQLSKQKCSCAFQSLLPLYSPAVEDFIKVVREVDVALAEDLEGSFPSVKAQT
The following text describes a protein:
Function:
RING-finger E3 ubiquitin-protein ligase that plays an major role in maintaining COP1 homeostasis in darkness. Negatively regulates COP1 protein accumulation by targeting COP1 for ubiquitination and subsequent proteasomal degradation in dark-grown seedlings. Negatively regulates the accumulation of SPA1 protein in the dark.
Subcellular Localization:
Nucleus. Nucleus speckle. Note=Is recruited to nuclear speckles by COP1 in the dark.
Sequence:
MPQRHSKNNNDLAYFTYDEKKKLGYGTQRERLGRDSIKPFDACSLCLKPFIDPMCCHKGHVFCRECILECFLAQKKDIQRRLAAHSSQKKQDKDEEEERLMLQKARELDEFDQQNHSAMPRNSDKNHNEDKNGFHGANSVKTTSFEEEALRTMKAFWLPSATPAASVRVDAPETHTVCPEGKEKLKLKNLFAIRFTEDNSEEEETKTKSASSSSYDKSYICPSCKVTLTNTMSLVALSSCGHVFCKKCAEKFMPVDKVCLVCDKPCKDRNLVGLKKGGTGFAEHDDHLEAKEYKHLGSGSGLGLVRPVKT