lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MPHCVVSNCVHFNYKKSNLHGVALHPFPNDLSRIKLWLQQIGLTTDEIDYLAQKVVEGKRKKTDSHRMCSAHFTPNCYIVQDAKLVLRSDAIPTMFPGLSSSTTNQQNFLSPPNSSGCEGEVWPKCIVNGCRQPIGGVLFHTFPNNLQRIKQWLCQTGQDFGNIDAFAQKVLERRRSYDYCMCSAHFPPDCYIFQEGRAILRTNAMPTIFPSRPQAQQQLVWNVWPPLMVAQVPVSAGQNSAPTATSEQTPPSVPKPEKKSCETADKGVQWPEFESNFDGEPWKVEHDHHYHCRPLNPDEPLGHLNLNEFFPRDIYPPWFWTKLSSKSDNLYQKNFLQNLEADQAWSSVEKVLVLLLQHLNNSPVYQRILDNKPMTERIVNEALEVIYLLTGQEWTVVKKDSIQRGINQMNGEIPIKRGDVAVYFSMDEWEYLDEHRDRYLNLLMDEHLPFTQFKIPEDWGEEETTNQDMLDDPYVDPPLSEDQEDDDDDSSMSDWHPDQNYRPKTDASSSSDEESSAPKSKRRSIKKSRSESDSDNETSSEHSKSSNPLPADTQEPPDTEPRKCNGCDITFPNKSQLDLHLTLSPECLMFVGPEDEDEKPEVLPEKKNTHDCEECGKSFTRKAELRKHKKKHIKRKSIKCEDCGRRFFYRSQFLIHRRVHTGERPYQCKECGAQFGHKCSLVIHQKKHTGEARFTCGKCGRQFEAKAKLNKHVKIHERETVSCPQCSKCFTYKAALFKHLKVHKNS
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MSRLVQIAQRSNKAPVGFKVQLVVHRLSANLALKHDTELVAVIMGRKKKIPSKSGLYQPADPGDDGSLRRLNGTRAIQSSQSRSGDTGEVVWGDMVAFSSTLYMAKTGLFQAKRFQIHVNTSGEHGKTVAVFEFDLAELVPVSKDSGKESVRLNTAKCADDPRACISITVVSSRVNRDRDGPGYDKERSFVEDSTSEMGSEMSAYTNHSRASSLASNCRRNIDMPIPEHIGEDAKTNAIRRPATSEEAVSAADNARDELVKALQNLEVQLRESESANVKLEATIEQKDREIERLTRMAAGIGTSSEADAEDGVMQVDFLVYMTLKEQYDALKLEHEACLTTQKEDKTSRAATGMYTIADVENEEEEEVKDRDGAKEDVRDDASEASSANEYVDAEEPHLVAEVNALKQMLATQRSEAEQLNVTIQELTSSNKVLESQLRELRAAIEQKDEELQLSTAALQRVESARNEVGDAEAGEAEAQAQTALETALSDNKRLERQLLKFDGAMTAMEEEKARLLTQLREAEIASAAAQDKIVKVQNALDQLESESQTLSTKLEEADSARERAEENAVAAEATVGTLQQQVRDVSTQLHETQQELETLRDQQLTASTAALEEAAQKHQMLERLWEDVKTENERLQARVEELEFRLAQSESDGDEKATELQAQVDEVKREADALREELEALRTSKTQVESESNERELQLREATETHRRISVNHDERLSAEIMAREELLTRLQEQVQQTEKVSVDLSSKVVALEQELDYFQGELIESKMKVATLTQNNDELAMRNRHLEKDRASASKNEPPAKARGKTLAGQDRTQARMDLFARARSVIDHRGASAVARRPSYEQEQDDAGHTQDRVLSVPRAKVHALLDEMQASASWGEKENEGEERRMLSELQKCVLDAEGRQALEKLPKRMCAYEFKPGDIAWNCKVCQVDETCVMCNDCFISSDHEDHEVFFYYTHSGGCCDCGDTEAWAPEGFCTRHKVREGGAGAQDANPLNFLPPDLLVNSRECIGEVMKLVLNSVKEARYGSVINEDDLEVTSQEFATALNKAHPAIAWG
The following text describes a protein:
Function:
May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGLGSPVDRPSQQLPAEAPRALRPPGPASGAPTRARAGTEPGRVLRPRDLRPLCAPTPASLSGSPGPAPPRPAPPAPPRPGGPAPPRALALRPLPAGSRRSGRSERGPGDSGSRRRGRSMGRFRGGLRCIKYLLLGFNLLFWLAGSAVIGFGLWFRFGGTMKGFSSEDKSPEYFYMGLYVLVGAGALMMAVGFFGCCGAMRESQCVLGSFFTCLLVIFAAEVTTGVFAFIGKGVAIRHVQTMYEEAYNDYLKDKERGNGTLITFHSTFQCCGKESSEQVQPTCPKELLGHKNCIDEIEAIISVKLQLIGIVGIGIAGLTIFGMIFSMVLCCAIRTSRDVI
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
Subcellular Localization:
Cytoplasm.
Sequence:
MSTSIADAFKKLNVSPESSTSEHEKIFNVSYEYLSKVKKFNDLKASKNCLVALINLDKYYKAEQIIRKLPSSLVNSLILEVAYVYYKIGKVQELVKLYEATNENILPNAVDIGLKHVLAQSYYKIGSYEKALELYKELIKNNQYDDELDLVINEKAIVSQLNFQKGGKIESSTTTNANNYDLLFNEALIKLSTLNTTQTLALLDKASQVVHAELSGEDLVSELLPIKLTTAYVYQLTGESNKSLEILESIDVEKINDLLIKLIVKNNLYSHSTITNINLVDRDLNYQQNLHKLSQKLTVLQYERVLKNSLVLKFASGTLSKSQLNNQFINNFQQTFPGDLLPLSYKVLSTLNIDHKDLQDLTKSKQIGRKLVKYIPTQTDNDLKIVATLILVSVNAQIGSFDQSLPILEQLTHESLATPKALPGLIGTLIAVYENTHNTKKLTDLLLKVLEKLLYTPKELLSGDINYYNFAKIVAFKALNQGHDKTATQLFEYLYEVNSNDQLIHSILSNTNNDLLPLDELTSKKPIDEILSVDIDTLIPTTKNKPIKPIVKKVSKITKKKQNPKFGPNKVLKPIEDLQLDEERWLPMKLRSYYKPTKKEKKKASGGGGQQGATESSTRTTSSSNNKKKKKKGKK
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MLYLNRSKFQQFPFHLVTPSPWPIVTSFSLLGLTLTLAFTMHGIIGNIYPLLLSLLVVLLTMTLWFRDIVAETTYLGDHTLAVRKGINLGFTLFVVSEVLIFASLFWAYFHSAMSPDITLGNVWPPVGIEAVQPTELPLLNTIILLASGTTITYSHHGLIEGNRKHALSGLTITFWLIVTFVLCQYIEYSNTSFTITDGIYGSVFFAGTGLHFLHMVMLTIMLGINYWRMRNYHLTSTHHVGYETTTIYLHVLDIIWLALYICFYWWGV
The following text describes a protein:
Function:
[Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome. May control RUNX1 gene expression. Binds to and represses APOB gene promoter (By similarity). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity); [64-kDa C-terminal product]: May promote apoptosis.
Miscellaneous:
MISCELLANEOUS: Seems to bind calcium.
Subcellular Localization:
[Double-strand-break repair protein rad21 homolog]: Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase, scattered along chromosome arms. During prophase and prometaphase, most cohesins dissociate from the arms of condensing chromosome, possibly through PLK1-mediated phosphorylation (By similarity). A small amount of cohesin remains in centromeric regions and is removed from chromosomes only at the onset of anaphase. At anaphase, cleavage by separase/ESPL1 leads to the dissociation of cohesin from chromosomes and chromosome separation (By similarity); [64-kDa C-terminal product]: Cytoplasm, cytosol. Nucleus.
Domain:
The C-terminal part associates with the ATPase head of SMC1A, while the N-terminal part binds to the ATPase head of SMC3.
Sequence:
MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDDDMLVSTSASNLLLEPEQSTSNLNEKMNHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNGSLGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFFLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREEQQPQQQQPQPQRDVIDEPIIEEPSRLQDSVMEASRTTIEESAMPPPPPQGVKRKAGQIDPEPSIPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEEEEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRFHII
The following text describes a protein:
Function:
May function in EGF receptor signaling. May play a role in compound eye morphogenesis.
Sequence:
MGVRGLTSYIAQRAEIYLKPHELHSTALVIDGDNLSCNLYKDVTGSYSAFGGDYDDFYRAVVQFFQVLAECNIRPYVLMDGGYEERKLRTVSTRLRNKISVIKKINPNASITLFPLHLKEVFVDAVRDCGVPVMRCVFEADDELAALARKLNCPVLSYDSDFYIHNVKYIPLITLTVKVLTKQVKDKNSSNQKDSRDLRHCEAKNVKKRTRANKIVTGIQTTGLTASTKGSSKTYKYLDCCIYRVSHLCGRGTLSPEKLPLFAALLGNDYIARSAFKNFFAAGMGKAGRSRKLKLQQKRIQVILTWLKEETAESALAKVLSRLKKNQRDSLVSQVNAAISGYSNELCHAYDYFDEHYENAFPYIEPVSEEECSDDEHSSSSDEKFSDVEEGEDQEEADNQDEEQQEENQDVDSGDEEEEEADEGLELEVEDKTLLFPQWFLDKLYPAHLPRSFVDLMHLRKYINNPQIEHFPFHDSNEVALPILNYVFALLHHVECEKIELPLEVDMDIEGSTVPYLTYLTRALRVTNVRYFKMPIEKKPAYPFDPLSPDARHLRAVFEDNAPNADTEKLFSKLDQLPEDLRLYFLAIIYWLHRSEHCDLLHLHSLILSLVVLRTIDVTIPAEREVKTFLKRFGKTLKAERAVRDKEAAEGIKRGIKPALLELSVPDRMAHVPKSDCYLTQERLLPHFHMQEIFKKKFDLYSTTVIHAFAEFQAVVYQLNGLNSLLDFPLLSPRMNQLYCGAFLYNMYDVLRNRADVRYHVENFLLPDSKLMFDFYCYLYDWCAEFIPTWKRLEVDPTAAKALQKKRLKKQRQAARKVELREAIADPNAEMVEDADPENDFFDLNNKFCALKVA
The following text describes a protein:
Function:
Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
Sequence:
MERTAEKQSPVDYGVQIRFINDLQEPKKAPKARAKPGSYGVAVRVQGIAGQPFVVLNSGEKGSDSFGVQIKSDGSYPAGTTGPRPPDLPPELDLPENRYVRPQPSYSVSDEEHSAAPVPTRHKPHSKMGAELRRTQSHGNLLAATDGPMATSSRSSSTLNIAHPTHRKGSGIGVAPSSDSESSVSQHAGGDIDTEPLSSVNSLISKFDGKVQQRGRAARRSRLASEERKRSQSLDARSTVPNGRAVSAPSPLPTGAGRSAMVNRGTEERPQSKAQTELQLKSTPDLLRDQQEVAQPDSSEDPKELIYGILKEGSRDSGAMLKRKAALVLEKLQEVAAPTKGTACSQPQHHALAQRVEELQERLDEESKLRQKLELTKERSTTRALEEAQEESARLRAALEKRMQELQRSSKELGEAKAAQMRAEEQLKAVRTEMGTATDTNALYRELEEAREELEEALSSRQRLEEHLRLRERELTALKGALKEEVANHDRELERVRLQCHSDMEQLRRSVEDISQNRADLESEKQKIGAVVRNLQRELEESAEETGHWREMFQRNKDELRAAKQELLQVKMEREEFEEELRELRERFAATREEVERARSSAADPAEMEALRTELRRAREAQRELMEEKEQREEVVRQREEELQVLRSTVQDEAQSHSGAMEQCQRKMERLREERDEAVRAKVSLEGEREAVEAALRELQEQHEELQRKVQGLETQLKDYERMGENWEGSQARLREKITKLEAERRRAEESLSEATDREQELLRAQRALETRLDEAQRGMARLTQEQQELSASLQDEQKQKEQLKRAKSELEEQKRLLDRSTEKLNRELEQMTEESNRSLAALKAQLEECKEKSRKEITDSQKQAKDRSAEVEKMQFSVGRLQDEVTRLKQALQDSQAERDGALLERDVMLQRLRGLEEEADAKRRSQDDRSRQLKALEEKSKRLEEELEEERSTAELLTERVNRSRDQIDQLRAELLQERSSRQDLECDKVSLERQNKELKSRLASSEGMQKVGSSVSQLEARLEELQDRLQAEEREKSVLQSSNRKLERKVKELTIQIDDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLEAARKKAQRELEEQHELNEQLQGRIKALEKEAWRRAARAAADSSLQDDALSSDEDLDSAYGPSSIASLLNEANLQTSSC
The following text describes a protein:
Function:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Subcellular Localization:
Nucleus.
Sequence:
MARVTLPVVLPSVVDELEVFNLPNPASGKRQFYGQDKSSKRLYELIQVDNGTPRSWLFEKRVQSGAMTTFCPDDDCLRPRARQVLTRPDEQFTTADNIFHDPENPAVTRLEHVPQLDAMLSLVCDAKGDDDFRVYRINDAKLLQWLIAKLDTMADGIAANEVCLLNWLKRTSLEGLFNTVPCPSKVSHELDRAGSQITPSGVASASFKAISTPSNVTARQRYSYAAGIALLTIHDQASGSRSPFISMHLGNTSP
The following text describes a protein:
Function:
Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.
Sequence:
MSITSSLTSTTLCGASALARSIEFPRNHLSTPFESSKICLTTYPKKNATWNLNEKITPVQGIRCHAMQVETRELFTAGKKFQLSDVIEGQQFDREMLSAIFDVAREMEKIEKSSSQSEILKGYLMATLFFEPSTRTRLSFESAMKRLGGEVLTTENAREFSSAAKGETLEDTIRTVEGYSDIIVMRHFESGAAKRAAATANIPVINAGDGPGEHPTQALLDVYTIQSEIGKLDGISVALVGDLANGRTVRSLAYLLAKFKDVKIYFVSPEIVKMKDDIKDYLTANGVEWEESSDLMEVASKCDVVYQTRIQRERFGERLDLYEAARGKYIVDKALLGVMRKNAVIMHPLPRLDEITPDVDADPRAAYFRQAKNGLFIRMALLKLLLVGCSEELELSFWKMIGNPVIQVPSSLMPSSSMMACPRVSPSGLPYLPPKPRTRHLVARAASNSHGQPSSDEGKSPLTVVLDVPRNIWRQTLKPLSDFGFGKRSVWEGGVGLFIVSGATLLALSWAWLRGFQMRAKFKKYQTVFELSQASGICTGTPVRIRGVTVGTVIRVNPSLKNIEAVAEIEDDKIIIPKNSLVEVNQSGLLMETMIDITPRNPIPEPSVGPLHPECGREGLIVCDRQKIKGEQGVSLDALVGIFTRIGREVEEIGVVNAYTLAERAASVIEEAKPLLRKIQAMAEDAQPLLSEFRDSGLLKEVECLTRSLTQASDDMRKVHSSIMTPENTELIQKSIYTLVYTLKNVESISSDILGFTGDEATRKNLKLLIKSLSRLL
The following text describes a protein:
Function:
Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.
Sequence:
MSHTLSQKYLSTRGGSYGFGFEEAVLKGLASDGGLFIPEEIPSLPAGWETEWRDLSFEELAFNIMSLYISPSEIPSEDLRDIIKRSYSTFRHPERTPIVELDAKQNLYLLELFHGPTFAFKDVALQFLGNLFEYFLIVGATSGDTGSAAIYGVRGKKDVSIFMMFPTGKVSPIQQAQMTTVLDANVHNLTVEGSFDDCQDIVKALFADPDINSTHNLAAINWSRVMAQVTYYFYSYFSLVKNTGSDDSKVRFVVPSGNFGDILAGWFAKQMGLPTEKLVIATNENDILDRFFRSNGQYTKNSGEGSGVKETHSPAMDILVSSNFERLLWFLALRTNTSSDSIEERRKQASENVSQWLSQLKTEGGFTVPPAVIEAAKTEFESERVSNDETIAQIRSTYNSSFPSNLTPGSATSSKTGGYILDPHSAVGVAASLRSIQRNPGTKHISLSTAHPAKFASAVDLALRAEDGYDFTEVLPQEFIGLEQRESRVTPVRAGAGWEGVREIVKAEVEQELEGKR
The following text describes a protein:
Function:
Kinase involved in the biosynthesis of the core oligosaccharide region of lipopolysaccharide (LPS). Catalyzes the phosphorylation of the second heptose unit (HepII) of the inner core.
Sequence:
MIQKSKIKDLVVFTDENNSKYLNVLNDFLSYNINIIKVFRSIDDTKVMLIDTDYGKLILKVFSPKVKRNERFFKSLLKGDYYERLFEQTQKVRNEGLNTLNDFYLLAERKTLRFVHTYIMIIEYIDGIELCDMPDIDDALKNKIQQSINALHQHGMVSGDPHRGNFIIKNGEVRIIDLSGKRASAQRKAKDRIDLERHYGIKNEIRDLGYYLLVYRKKMRNFMRRLKGKPAR
The following text describes a protein:
Function:
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKTLDRRLASPWRRSGLAVLAGALPVLAFPGPALWWWAWFALVPWILLARTAPGGKRAAYDGWCGGFGFVLAMHHWLLPNLHVFTFVIAALLGALWVPWGWLVHRTLGGTPSSRRVAAALVVLPSGWLLAELVRSWQGLGGPWGMLGASQWQVAPALRLASVGGVWLLSFLVVAVNAALAVLVAVRRARVPALAGLVATAAATSAAWVWSPRPDTDERAAIAVVQPGVVAGADSADRRFDREEQLTRRLADRDLDLIVWGESSVGFDLDDRPDLARRLAALSRETGADILVNVDARRSDKPGIYKSSVLVGPQGPTGDRYDKMRLVPFGEYVPFRSLLGWATSVGKAAGEDRRQGTEQVVMDVGDGLRIGPMVCFESAFPDMSRSLVADGAQVLVAQSSTSTFQHTWAPEQHASLAALRAAETGRPMVHATLTGVSAVYDANGARIGSWLGTDASASRVYEVPVTHGTTPYVRYGDWTVYAALGILAAWGAAEGVRTVRLRRNRPARPGPPARTAHGSPARPGH
The following text describes a protein:
Function:
Probable membrane-associated metalloprotease that may be involved in chloroplast development.
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MASASLASSVLCSSSGSTSRSAAVPRAIRIPLFPKNQHRPPLRPLRSSSVARRSLQQEQEERADPASSVAVASGERHEEPTASHHVGGEDDGTTASGHAGGAEGGQGDGDGEEKRSTDEQQEVDWKSDEEFKRFMGNPSIEAAIKLEKKRADRKLRELDREPDANPVAGLLRGLAKDQLAREKQRLELAEQTFKALDLNKLKSCFGYDTFFAVDVRRFGDGGIFIGNLRRPVEEVRPKLEKKIAEAAGTEVTLWFMEEKGDGDITKQVCMVQPKAEIDLQLEITRLSTAWGYLSAVALAVTTFGTVALMSGFFLKPGATFDDYVSDVLPLFGGFLTILGVSEIATRLTAAKYGVKLSPSFLVPSNWTGCLGVMNNYESLLPNKKALFDIPVARTASAYITSVVLAVSAFIADGSFNGGENALFVRPEFFYNNPLLSFVQVAIGPYADELGNVLPNAVEGVGVPVDPLAFAGLLGIVVTSLNLLPIGRLEGGRIAQALFGRSTAALLSFGTSVLLGLGAISGSVLCLAWGLFATFIRGGEEIPAQDEITPLGSDRVAWGFVLAVVCLLTLFPNGGGTYSTSFLGDPFFRGGI
The following text describes a protein:
Function:
Component of the male-specific lethal (MSL) histone acetyltransferase complex, a multiprotein complex essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). The MSL complex specifically associates with the single X chromosome in males and mediates formation of H4K16ac, promoting a two-fold activation of X chromosome. In complex with msl-2, promotes ubiquitination of histone H2B. In addition to its role in dosage compensation in males, regulates the activity of gene promoters: acts together with Cdk7 to promote phosphorylation of 'Ser-5' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit Polr2A.
Subcellular Localization:
Nucleus. Chromosome. Note=Msl-1 is associated with hundreds of discrete sites along the length of the X chromosome in males and not in females, and is also associated with 10-20 autosomal sites in males.
Sequence:
MDKRFKWPPKKRANYLESPYPHIPSRGRQRNLHGHPNQTQHLHQHPGKIYERQQYGNGRGGHGGGNNNYRKLLHSLPAEHGGGAMAPPSSGGTVCAGADMVKLISENNNLRRMVMLNLNLMQEQTDSIAAKDKELDDQSAKMSVVKAQNEELKQAVAQLEAANQELCKQLRRKNQRRNDNDDDDDDPPLPPAAPQQKLIRCHAETQTVFREREQGTQTIDAQPQFANALPRGINMKESPALDHHAGAVTNQPASKRSESKGRGEFNGKKVSTFILQRMNQDFEHHIHEQTEVAEEHEMEAHKEQISQEEDQLVAEEDHLHMQEVHTEEVVGGDIFHDALESIEMEVVTEELVDMEEHGQSVDANGHIEEDDDEDDEDDENSDKDDDSEEDDYPWMHSDADVNARTEEELWQNQNYLLELDPTEEKTCAPSAHSTPNHQQKSSTQAEIRKEGNQNRITEKLLQLKPEPMVDALEAPILPKWVAFKKKDKEHESVPESPEVPKQQPHQEDAIVDHNAIKNQLEVPKPDLKPKDQPKDEQRQDGQLDVRVEPQEDVRKVQKETLKRQPEDAPKHLPKAVAPKVTKTSSRESTLPKANTADIKDAPAQKVIANHQSTKTQTDPVKTQRLQVKIRQYEMHPDMRTGSSAPSDIRKQKNVDPVSTPETKTIKSKSMLVNDKKTTSETSQSPDQEIDVETVRRKLAEHLKKELLSQSHSSQVTLKKIRERVATNLIYPPPSAPVSSTTITPAPTPSTTPTPGSTPQHAVTSSMDQEISAAKSKSKAAEQIATPLTPQSNSSVSSTTSTIRKTLNNCSPHTYSKATARSGKLQSRFRTATFPYSTRTWEDQEFHCDNEFFLEEADELLADNPSLEIPKWRDVPVPPSSDKIDTELLSDATFERRHQKYVKDEVDRKCRDARYMKEQIRLEQLRMRRNQDEVLVALDPLRASTFYPLPEDIEAIQFVNEVTVQAFGENVVNMEARDDFGVPWVDAIEAPTSIARSKALAEPVATLASKKIPTTAAEARHQENHSSYVFPKRRKRQKNR
The following text describes a protein:
Function:
Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion. It binds specifically to the sequences 5'-YCAY-3' and regulates splicing in only a subset of regulated exons. Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 snRNP binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhances spliceosome assembly and exon inclusion. With NOVA1, they perform unique biological functions in different brain areas and cell types. Uniquely regulates alternative splicing events of a series of axon guidance related genes during cortical development, being essential for central nervous system development by regulating neural networks wiring. Regulates differentially alternative splicing on the same transcripts expressed in different neurons. This includes functional differences in transcripts expressed in cortical and cerebellar excitatory versus inhibitory neurons where is required for, respectively, development of laminar structure and motor coordination and synapse formation. Also the regulation the regulation of intron retention can sequester the trans-acting splicing factor PTBP2, acting as a variable cis-acting scaffolding platform for PTBP2 across various natural conditions.
Subcellular Localization:
Nucleus.
Domain:
The third KH domain (KH3) recognizes specifically 5'-YCAY-3'.
Sequence:
MEPEAPDSRKRPLETPPEVVCTKRSNTGEEGEYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLVQGTAEALNAVHSFIAEKVREIPQAMTKPEVVNILQPQTTMNPDRAKQAKLIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPEGINLQERVVTVSGEPEQVHKAVSAIVQKVQEDPQSSSCLNISYANVAGPVANSNPTGSPYASPADVLPAAAAASAAAASGLLGPAGLAGVGAFPAALPAFSGTDLLAISTALNTLASYGYNTNSLSLGLNSAAASGVLAAVAAGANPAAAAAANLLASYAGDAGAGPGAGAAPPPPPPPGALGSFALAAAANGYLGAGAGGAAGAGGAPLVAAAAAAGAAGGFLTAEKLAAESAKELVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFLPGTRNRRVTITGSPAATQAAQYLISQRVTYEQGVRASNPQKVG
The following text describes a protein:
Function:
Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
Sequence:
MAAPLSGTTYYRKRTRLVGSLGVTRRKSAALLRIVLIVMASIAIFLLLLFAQPSRPAVTGGVTQNLLDTSWTFRNRSDNRKLTPITGKAVVPGDIYADLQALKAIGEPLYADNDVRLRWVARENWTYSTEFDVNERILKVAMTIWHKPSQLIVFKGLDTIAQVLLNGQEILSTNNQFVQYTADVTGKLKKAGNTLEIHFESPISYGDRAAREYKNEYGYSIPPDCTIEMFHGECHANYVRKIQAQFSWDWGPAFPTVGIFDAITLHGNDGLHLERVHVDTTFNDDDTVSIRVHADVRSTMPGNVHWDVSIPEMNKLYNARTVLNSGKGLHTMSAQFMLNKKQFELWWPNGMGAQRMYEMRVRLTREDKKAFVEKTVRFGLREVELIQDYIDETNKTIGREFYFKINGQPVFLKGTNWIPVSPFPARNNSERMEFLLESSRIAGMNAMRVWGGGRYENDEFYAMADRKGILLWHDMMFACSLYPTDPAFLESVSTEIEQNVKRLKNHPSVLVWAGNNENELGIAGGWWGAMGYDEKQRIADYRILYKGLIGKIVTEIDPTRPYLLSSPSNGVETDRVGGVSDNPGSERYGDIHFYNEVKNLWKDSSYQTPRCATEYGLQSIPSGMTMSKYLPQSEYYYLSGNFTHRQHHPGGVETLITMIFAHFPLPPFCSGVRSNNSYSVAAHEAKQCFAKNPPSLYSLIFLAESGFLDRFAYFTQFHQALTYKTETEHYLRFRGRLTDDGLGHTMCALYWQLNDVWAAPTWSSIDWDLRWKPAHYEARRFFAPQMVIVYLDDNAMLEAFAINDRPETASMTVLPMILYLNVRKLIDQRIRRLKNGPVQVFAFNNAFEPIYKVEKKMDLPPYSSTPVDVSSLNKWKSSKNDLSLESLVFTGELLNLTQQRVGYQSTVVPDRLWKVDMKRTGDVTVQSFKKVNDLEYKVVIEATAVAPLVWIEVQVDNLQAYFDDNAFTMTSRTRELTLTLTKKYDRDLTADDLYACALKSCYV
The following text describes a protein:
Function:
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
Subcellular Localization:
Chromosome. Nucleus. Chromosome, centromere.
Sequence:
MFSQKARKIRRQSENHSVKSSGRRSRDSRITNGEKAEAVTLFEVVCIGKGAIQSVVSDWVEVYQEDRDAALLDLLNFYIQCSGCQGVVTAEMFQNQGNQDIVQRLTEEFDKETGLQFKKFMAFPWILTITWPNNMENGDYPLSKSGIYWKKFRANICELTAVLVQKCQYNAIYDGYLLDTVISLLLGLSDSCIRAFRHTSTLSAVKLHTALVRIILNLETSIHNLQRLYNVKQTRLTLKKASHRMEQIEKKRNELQQKHSEIKNMLDALFKGTIVQRYRDVVSDIRALCIEELGIWMKMYPQVYLNDSCLKYIGWMLYDKVPDVRLKSLLSLQGLYENKDFVVKMDLFSTRFKDRIISMTLDRDHDVSVQAMKLLVFMSQNCEDLLTKEDCDLLYQCVYTAYRPLATAAGEFLYKRHLNQAEGEESRGTRCNAQQLKFLLTFFCENKLHEHLTYLVDSLWDCNPRLLKDWQCMSSLLLQDTQDGEDALNAIQQSLLIELLLASVRQAVEVHPPVGRGTVRKMLSAKEKKVQLEDHIKITEHFAQTLPLLLAKYLKDQRKVANLLQILQYFKFEVYSTKCLDKDLEALLNELKHVALTHSDPEVLEACSKAYIGLGEEDLESHVSVSLARRQLIKQLVDTFSQMLHDLLQEGEEPLSSQGAHQMSCVLRKLAAFQNAHDPTEWNLYEKTSQLLLYDVENCCFSVQLLVPAFQCMYYALLWNVVAVMEETISKEEPVLFREHVATFWQLCKHYLNHQDRSVQEQAFMSLCDVLLLLSHYRNGIYCCMDSALQSELFSFVHHHVFQSDEEKHKGVGGSEKDKAVISEGLHKRQNLLAAYCKLIANNIVEMAAASEIYKQYIKAYNDFGDIIKETLSRTRQNDKIESTKTLILCLEQLFQKHREVHGSATLSSPSFFNIKEMARRFSLTFGMDHVKCRESVVMIHKQGIEFAFREPALEDNFPPPNLAFLIPISEFSGKLLKPDKRLVYGYLQRIANEQMLLREGVEWNPLVFYTHSLLDNLDEESSFTSSYYSRDFKTTSSPTKRKPFSGRRGMPEALKMYYPVQRRKRHLMHGDKLDDGISLYSLQPSVKRLSSHGDADEGNEDVEVDEVLVTKEIILHTESQDSTG
The following text describes a protein:
Function:
Component of TORC1 complex, which is an essential cell growth regulator that controls plant development. Acts by activating transcription, protein synthesis and ribosome biogenesis, and inhibiting mRNA degradation and autophagy.
Subcellular Localization:
Endosome.
Sequence:
MSQPCVVLATASYDHTIRFWEAESGRCYRTIQYPDSHVNRLEITPDKRHLAAACNPHIRLFDVNSNSPQPTELISGDQNGNIRVWDLRANSCSCELVPEVDTPVRSLTVMWDGTMVVAANNRGTCYVWRLLRGKQTMTEFEPLHKLQAHNGHILKCLLSPANKYLATASSDKTVKIWNVDGFKLEKILTGHQRWVWDCVFSVDGEFLVTASSDMTARLWSMPAGKEVKVYQGHHKATVCCALHD
The following text describes a protein:
Function:
Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity); (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with NR5A2 to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII).
Miscellaneous:
MISCELLANEOUS: [Isoform 7]: Due to intron retention.
Subcellular Localization:
Nucleus.
Sequence:
MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAELPNGLGETRGSEDETDDDGEDFTPPILKELENLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYSGPPPGPGPGPALPAHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSHSLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVTQSPFMATMAQLQSPHALYSHKPEVAQYTHTGLLPQTMLITDTTNLSALASLTPTKQVFTSDTEASSESGLHTPASQATTLHVPSQDPASIQHLQPAHRLSASPTVSSSSLVLYQSSDSSNGQSHLLPSNHSVIETFISTQMASSSQ