lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response (By similarity). Binds to CCL21. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYLEVSERQVLDASDIAFLLENSTSPYDYGENESDFSDSPPCPQDFSLNFDRTFLPVLYSLLFLLGLLGNGAVAAVLLSQRTALSSTDTFLLHLAVADVLLVLTLPLWAVDAAAQWVFGSGLCKVAGALFNINFYAGAFLLACISFDRYLSIVHATQIYRRDPWVRVALTCIVVWGLCVLFALPDFIFLSASHDQRLNATHCQYNFPQVGRTALRVLQLVAGFLMPLLVMAYCYAHILAVLLVSRGQRRFRAMRLVVVVVVAFAVCWTPYHLVVLVDILMDVGVLARNCGRESHVDVAKSVTSGMGYMHCCLNPLLYAFVGVKFKEQMWMLLMRLGRSDQRGPQRQPSSSRRESSWSETTEASYLGL
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
Subcellular Localization:
Cytoplasm.
Sequence:
MSRLTNTEFISSLKDAFDGISKKEKKHSLYFTQKRLSPANVEPEEPSKEYPLLIRVAYTTGGKKTKLTTEVDPSNLDEFWKQYTDVMKAGMALKKKDKKRKRK
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
CLGMSAMHEGIQALEEVGEVLLDCITNSNAEKTVKTAMEKQTLILSRLLETRKSAAQLVSDLLHTEEKVAHDLLDIQSQRNGVLEELDKLEKELQKSKSRKDMLQAEIEFLQKEIDSLREAEREVQVLQAEVDEDTTEIIPSTKYIVQLYHKVTKIKWDFNTEPDILRGVHFGKDIVTPINLDTREHSEGFISDYLWSLVSTEW
The following text describes a protein:
Function:
Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented. Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response. NSs also seems to be involved in the nuclear relocalization of host PABP1.
Miscellaneous:
MISCELLANEOUS: [Isoform NSS]: Produced by alternative initiation in the N gene, but encoded on another frame.
Sequence:
MMSLLTPAVLLTQRSHTLTLSVSTPLGLVMTTYESSTLKDARLKLVSQKEVNGKLHLTLGAGRLLYIIRIFLATGTTQFLTMVLPSTASVDSLPGTYLRRC
The following text describes a protein:
Function:
Structural component of the gap junctions and the hemichannels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSIANAAAQAMLSDSLVMEGGADSRLRALALELPLDRVIKFVSVGLPLLLVSMAFAREISTGPQISCFPPHNFTSKQSAYVDTYCWDSLMHHEFDSSGNFEERSLWVHKMFPYSLLVMAVMMYLPALFWRFLVMPSLGSDLLFIIDELDKSYNRSVRLAQCILELRQNAPDHLNFEAELQRAKRERYFEYPLLERYLQCKQRSCFLVSMLFLRSLLLLVFISASCLYLVYFHLSAFLQDEFSCFVKTGLLRDEPWVPELVQCKLTGLLVFQAVSVANGAVYVLLVPMILFGLLRLFCWDRSFLSVYEVLPALGLLHGRKLGCPLSDLNVILLFLRANVSQLRSYGRLRAVGTLTPMLPRRGKKPKKGAGESKEEEEEAAEEREEREEEAREAREEGEHTLVDIMGVLAGSEGGKVNGTEQKPLPDDHLGLELSNHQGYHELKETPSCSYA
The following text describes a protein:
Function:
Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6. Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
KPAGTDPRILSLAAEVAKSPEQNVPVILLKLKEIINNTPLGSSELKKVKQDIYCYDLIQYCLLVLSQDSSRIQGGWSTISQLTQILSHCCVGLEPGEDGEEFYKELLPSAAENFLVLGRRLQTCFINATKGEEQDKLLHFFQIVTDSLFWLLGGHIQLIQNVLQSDHFLHLLQTDNVQIGATVMTLLQNILQINSGNLLKIEGKALHSILDEILFKLLSTPSPVIRSTATKLLLVLAESHQEILILLRLSACYKGLRSLLNKQETLTEFSRELRQLVDLLTPKIQQEVEEQKLHKAACLIQAYWKGFQTRKRLKKLPSAVIALQRSFRAKRTKMLLELNRQKEEEDLRLRLQLQKQRAMRLSRESRLSMLEIIHPGQVEKYNREIEEKSALTIQKHWRGYRERKNFRQQRPSLTEYKAAVTLQRAVLKFLAKCRKKKKLFASWHGLQELTDARRVELKQQVDDYVKRHPGSQMSDVASRELHAQAQERLQHYFMGRAIEERAQQHREALMAQISTNIEQLMSMLYICLCFINGITHARDVASKIFRPQIVFIPVLRKSYIIPVFNCIHSICYKFKYFNSIQITNFKDAVLFY
The following text describes a protein:
Function:
May play a role in developmental myelination of peripheral nerves.
Sequence:
MDQPGPPAPAREENEVKYDTNNNEEEEEEGEQLDLDSGDEAPEADRQAPGSAEAGDAGADAPATAATAATAGPCASSGHHPGTSQPTCGLDRPGEGCEKGPGVEPLKPGVPSRVNPYSVIDITPLQEDQPPPPDPDAEGEGGGLHVPSGYLVPVPCGYAVPSSLPLLLPAYTSPVLPAPPADPAETQEAAEDSQLNSLSSEDPANSEDPDQKEDSALARWVADPANTAWMENPEEAIYDDVPRENSDSEPDEMIYDDVENGDEGGHSSLEYGWSSSEFESYEEQSDSESRSGVPRSFLRGDHRKQLSHDLTRLKEHYERKMRELMANTVGAVEIQQLKHKHELKMQKLVRAAREGTKDGLEKTKAAVKRGRSFIRTKSFISADHRSCLEEEQNVFIDVDCKHPEAILTPMPEGLSQQQVVRRYILGSIVDSEKNYVDALKRILEQYEKPLWEMEPKVLSERKLRTVFFRVKEVLQCHCLLQIALAGRVAEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAILKKTCATKPAFLEFLKQCQESSPDRVTLHSLMTKPIQRFPQFILLLQDMLKNTPRGHPDRLPLQMALTELETLAEKLNERKRDADQRCEIKQIAKAINERYLNKLLSSGSRYLIRSDDVIETVYNDRGEIMKTKERRLFMLNDVLMCATVSTRAPSSRSASHDGGAVTSGQRYLLKWSVPLGQAEVVEYGGGEGVAEGGRCPTGPAPESLLAASTKPHRVYVGPGQLYQDLQNLLHDLSVIGHITQLVGNLKGNYQNLNPLVAQDWMSGLQRLILKKEEEIRAADCCRVQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWINSLQMAKLALEEENHLGWFCVEDDGNQIRKERHPLLLGHMPVTVAKQQEFKIECAVYNPEPYLNNENQSDSFSVAHGFLWIGSCTSQMGQIAIVSFHNSSPKVIECFNVESRVLCMVYVPAEDRPREPEGGGRVLGVPAVCLGTEEGSISIYKSSQGCKKVRLQHFFTPEKSTVMSLACTAQSLYAGLVNGAVAVYARADDGSWNSEPQTVIKLGVLPVRSLLLMEDTLWAASGGQVFIISVETLAVEGQLEAHQEEGMVVSHMAIAGVGIWVAFTSGSTLRLFHTETLKHLQDVNIATPVHHMLPGHQRLSVTSLLVCHGLLMVGTSLGVVVALPVPRLQGIPKVTGRGLVSHHAHHGPVKFLVVAAAALKADKDRPRDSPPPGADPQDDEQRDVPSSEGPGLCMGRGGPDAVWLGTSPGSITQGSDVSSSSGSPTPSQGSGSLEPRPEESLAQDLLRLPCTSPSRGRRARRPRASSVLVACGGQGHRRVSRKARPQRPEELASSLMVWQIPLLHV
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Sequence:
MKPVVVMTQTNDMQSDLVSIIHKPFIDIKPLNFDIHLLNQRYDWLIFSSKNAVKFFYKYLKGINVDNIAVIGSKTAQYCESLGIRVDFMPNDFSQEGFLKSFNQTNQKILLPSSELARPLLLAALSKDNEVVKIDLYTSVPNKQNIQDVKEMIEHQQIDALTFSSSSAVRYYFNEGFVPKFKSYFAIGEQTARTIKSYQQPVTIAEIQTLESLIEKILESRG
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MGTVPDPLRVTKASIVAASRKEESPGELQSVSPQPAQPDKNVSGIGNAPAELSLRLSSAAPALMQACVHESSPQDMTSPGMLNEVEQVSPKNNTPDDSQPQGSKESAAPDANATAKKELTSAPFLMSAVQHMHHAIRNDPPNTSTCPVPEDSLVKSEANSDREKPEKSSCPTRVTCCSSKNKVFCDFPSPENSQGIVQTPDRAVRIHSSPSADRPEGEEQKAINSTTVVSSEPLARGECSENRQPSDTVLDTTDEKSENPPLSPLTSREATCSSEARQVQLPTQHPTSRFKEASTMTCQAESEAKEVPGRAWQDAEVQAVASVESRSVSTSPSILPAFLKENPALEQENGQEQLRVICHDKGSGSRLLELSNSMVDPQESRQCPSIVPQVHIQAPVATSTAFKGGCKPANQPAEGLKSPLVHVASSQTPDTEEDLRSSTSKEATSRELTGTNLGSQKATTIAQISVLAGSQAEISLGLGNSGLRAPELVEKIANDHKTEPDCKLSNSRGGVNEDQPLESLDPTDKRDAKDKNPASPLIVKDHAPGATSTPDAKTLLLNPKSHGSEGPEVSPAPSPGRKSTVEEHRQTKTVTSLSLPSDGTGDSSPGSGKRTPSRSVKASPRRASRVSEFLKELNVTAAAAQVGLTPGEKKKQLGAESKLQLKQSKRVRDVVWDDQGMTWEVYGASLDPESLGVAIQNHLQRQIREHEKLVKTQSGQTRRSISSDSSSSKKLKGRQQGVLQSMLQNFRRPNCCVRPAPSSVLD
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MERTNDSMLTEFVLVGLSVHPKLQTVFFVLVLWVYLMILLGSGVLISVIICDSHFHTPMHFLLCNLSFLDICYTSSFVPIILDSFMTGRKRVSFSGCMVQMFLSFAMGATKCEFLGMMVLDCYVAICYPLRYPAIMSKGTYVPMAAGSWVAGLVDSVVQASLTIQLPFCANNVINYFVCEILATLELACADISISVISMAGISSTEGKRESFSTCSAHLTVVIIFYGTIFFMYTKPRSKSSVGPDNQGTFEVLISLSYGVMTPMLNPLIYSLRNKDVKTAVRNMLGRKNSDGI
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Subcellular Localization:
Nucleus.
Sequence:
MSEADMAIIKPEMMMKSYIWLETTDGSIQQVEQEIAMYCPMICHEVLQKGLGAGSSKNCAISLPQRVNPAMLSLILDYCRFHQVPGRSNKERKVHDEKFIRMDTKRLCELASAADSLQLKPLVDLSSRALARIIEGKTPEEIREIFHLPDDLTEEEKLEPLKNLMDDPRIRLLNRLYAKKRKELKEREKLKGKEVEERVDERSVDDLLSFINGKDHKVVKTSKSKKKNKKRKEHKNKVSHNLHSKQQGVQIVDETASSLGGVSNLPSMEEDIFSLKTDSEDGYVDDGMDPVLKEMLDREVEDFARRLNSSWVLSSGQERQPVHFSINGNGATRRLTAFQVMLGSLILLMVFGWQVPEFCGVTVKGNSRVRISGLTGTEGGDEWFDLSYIILDEASDPPKYDNVPADREDLPLKEHIIELREL
The following text describes a protein:
Function:
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
Subcellular Localization:
Cytoplasm.
Sequence:
MDPVTQAPAPEGVDAPEIDESLQPFEINLYLPKRPLIPSAAASANGLPETPSPLKVAVTPQETLNDLRVTITDSPEGYWLGAFCFRKPLASPNSTAKGGKVQLGERVPEWTELREIFEGVDKDKRELHVTHVPFNEADARAHVQRLRDLLSGGAADPSAIGVDAALSVQDAVRNPQEWQQDAARQNANGRAVTKKGVNDAAEASSELPLPLVDWAGWPSVTSIDLIPQVARRPRQLPVCVRQLSLASWNPPPQHCKLNGHLLYLQVGTLEGEVIFVTASTHGFYVNRSSGARFDPSPRPDGQDFASCSLFDLLCGFSPLFLSSFSKLFNDPLSSRDYFSAVPVTNALPAFPWLARNHTHHADALRSQAAFLLTGATSADALEGTRDWNDELQSARELPRTTLSERLMRDRVLNRIYSEFTQAAARAIPKVAAGEVQAMNPMDKRDAQMFIVNNLFISKGADGVDLYPHMGGDEAAHVAVGKDVQGVKTLNSLDVGGLCLLGTIVVDWKGERWVAQSVVPGLFRRRDDADELPEADGETTELAEAAPEKKSPEAKLAQSNKADLNDDTQVVYGGVEGPEVIRDNAAFHKLFHQVAQTLHLNEHQVEDAKGIKHSLWLSVDSKGLRGADGRRYVLDLARLNPVDINWLENDIDGAIHGSSSSPNQDAHYPHRMTLLRPELLEIYWDSEFRKWARAKLAARQEAKAAKDAKAKEAASKEDGEKTEAPEVEAEEPERLDSSEFKLTFNPDAFVEFKVADTLAEEHSKVITPITDESDASIAAVRQASDFLRKVAIPRFVTDVAAGLFTAADGGALSRQMHARGINVRYLGYVARLCSPEAKQELDQELIQKAGPGHEGFLNAFRLTVLQEMVLRASKRVLRGLIRDVEQVNVAACVSHFLNCLVGDKVNAHPKARPSVTPLSDVADAAWTKLTPETLREELKAEIRKRFRFELPASFFEQELRRAQLLREVALRTGIQLQLQEYVLEGKLADADGVVSDGCHGESQTNGNTTNKKNSKGKKKGGNEQQNGVKKSNVGAAAAKPTKAARATSFEPEDVLNLVPMVKDSTPKSTLAEEAFEAGRISISRGDRELGLELLLEGVSFHEQVYGLVHPEVARCYALFATIVHHLAGVAAMERAESINQAKSENKEITEADLPVVNEHLSMANAVRYQRQAVTVSERTLGLDHPETLNQYMNLAVLERSAGNTRESLLCQRRVLELWSLLHGQHHPDCINALSNVALTLQNARLFEASLRVYRSAHELALTLFGADSIHTANLAHELSQAYTLAGDLKTALAVEKEAWRVFEERLGKDDAQTKESEAFCSSLAASAVRVAKLEKEASERQARLPASRRGNSNAGGGAAAITGAGTTASGNGTANKSLDEIVRFIQGGSNGSVAKAKGKSKASRK
The following text describes a protein:
Function:
Severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MQASVANEIVKAVHKARNCALYCDYKTALQYYSSIRNEINLHTRSIDDVLCSQWMSLLRELESEAQIIRDTQAELHLFIDPNAAKRREPPDCDENRSSSSAEKAVVPRTGTKKKPRIGTSLANSGGSNISVQNAKLYGDKDRFGPAEGPQILPATRQPARGAASSYAAVSPPFSSGSSASAVPPRVSRTSSISGVGVGRPVAAAAGVGFRQGAGASSGTGAAARGRVKGKSAATRFVGRAGEEELVQLIEADMHVGKLPVTWDDIAGLEEAKRLLEEAVVYPVLMPDYYQGIRRPWKGVLMYGPPGTGKTMLAKAVASECNTTFFNISPATLTSKWRGDSEKLIRVLFEMARHYAPSTIFIDEIDSLCGQRGGGNEHEASRRAKGTLLAQMDGVGVDTDKIVMVLGATNHPWDIDEAMRRRLEKRIYIPLPDAADRVELFKINTKSIKLGSDVDFVKLSQLLEGRHYSGADITNLVRDAAMMTMRRFMKEADKTTLKENAAEIGRQVAEQPINMSDFLAAMTKVPSSINADNIKKFEAWKKEFELNI
The following text describes a protein:
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Specifically targets CEP192 isoform 3 for ubiquitin-mediated proteolysis and thereby acts as a regulator of microtubule nucleation activity.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MASLRNADMHLRTYIKQHSLPEIYEALLCGLLVMCPENPLQFLEQKIKEMLKKGHNALLWDAFIEEAKKPKFKAMTGSYLEYLFGRDEDQLVSSELLKKAYSFYINNLQKLYFNAWIEYCSMRKARKQELNLKLQVADNHHAHTLLRSIVRQWDYWVKYRKQQQSVAATKIKKVFNDAFMKKILKAWHAETQDSKKKREYFERLERGDMDDYGNFNSSPLREGEDNVSQLPPKAVLKIFSFVDLIDLARSAQVCRSWKIISQNSSLWSSIDFSSVRQYVQDKFVVNTLRKCRLYVIRLNFRSCSSLHWPTFKAIGECKNLQDLNLSECIHLNDESIRIICEGCPALLYLNISHTDVTNATLRIVSRCLLNLQFLSLAYCRKFTDKGLQYLGSGKGCPKLIYLDLSGCTQISVDGFTFLAAGCNSLQQLKINDMFTLTDKCITALLEKCQNILSISLLGSPHLSDVAFKVLAQGRKLAKIRIEGNNRITDSSIKAICKFCANLNHIYVADCQKITDVSLKAISVLKNITILNVADCIRISDPGVRQVLEGPSGTKIRELNLTNCIRVSDLSLLRIAQKCHNLTYLSLRYCENLTDSGFELLGNMASLISIDLSGTNITDQGLSALGAHSTIKELSVSECFGISDIGIQKFCQQSRDLEQLDLSHCSQVTNNTVKTVAFCCKLLTSVNIAGCPKVTDLSIQYLSGVCSYLHVLDISGCVNLSDRTLKCLRKGCKQLHILKILYCKSITKAAAVKMESKLQLLQYNNEDPPLWFGYDRHGNLLHGLSHLEETEEAEENTPKMLSNASDESL
The following text describes a protein:
Function:
Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin.
Sequence:
MRPSSCIPFSVGLAVVAHAASPSTLEELCTVSYLQTVLPSSKFIQGITIDSDSLTTSVVTNSTVSSVDYPTATIDYCNVTLAYSHDGIDGDRVLLQIWLPAPTDFQNRWLSTGGGGYAINSGTRMLPEGIIYGAASGLTDGGFGGFSVNADSAMLLANGTLNYEALYMFGYKAHRELSLIGKAFTRKVYGMADSEKLYAYYHGCSEGGREGWSQVQRYGDEWDGAIIGAPAFRWSFQQTQHLFSNIVEKTLDYYPPPCELEKIVNETIVACDPLDGRTDGVVARTDLCLLHFDLKHVIGKKYSCAASTTAPAQSGTVSAKAVEVAKTIINGLHDTQGRRVYFSYQPSAAFDDAQTQFNADTGKWELSINQLGGKHIALLMNKNSTTLDSLNGVTYDTLKDWIISGMQEYYSTLQTTWPDLTPFHQAGGKVIHYHGDADFSIPTASSIRYWESVRSTMYGNLSYKAGANALNEWYRLYTVPGAGHCSTNDAMPNGPWPQTNLATMVEWVEKGVTPVTLNATVLQGEYEGETQQLCAWPLRPLWKNKGKTLNCVYDQASINSWHYDLDAVPMPVY
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of a broad range of substrates, including endoplasmic reticulum membrane proteins (ERQC), soluble nuclear proteins and soluble cytoplasmic proteins (CytoQC). Component of the doa10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains. Also recognizes the N-terminally acetylated residue of proteins as degradation signal (degron).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The RING-CH-type zinc finger domain is required for E3 ligase activity.
Sequence:
MNADDEICRVCRCEGAPDSPLFHPCKCTGSIRYVHQECLVEWLGHSKKTHCELCKAKFEFTKVYSESMPRTIPFTILCRKLASTLKQRVIFFTRVLLTFFCWTVLLPLIFKHVWNLNFKIGDTYTIHARNKTFTAPQKPGYFESISQITSSPRLNTLIANTAEGQVLTFVVTFILITAFLVREWVLQNAVQVADELQGQQFENVNQNNQAQAAAAAAQNLREVREARQRLAMVMEHLRERQEQRNLELQRNGSFEEIERARQRFALLGDNIREPQEEENDVDVDEIFNRQQLNQPALDLNDANSSNSVPVEFNSLHSQNVDYRDEVDSLRPQFNVDEQSSISHSSNASENIVDGAVTQANGIESDFTRVDHEPIIVNNDDENGNNESENEEVIEEDNLNRNVIAEAQNQVVADEERNAVARAAQIAEADDADDFDGILEFLGLRGPITGFLQNCLVIAFVVSVFLTTAVGIPYMSGRLMVEWILFIIHRPTFILRFILSFVNILFDWTVGGAFNIVKILTKLPLLSTVFVKLKLQGIFSSSFQQVSNNMYSWIYDHVFSSSDHAYESLIYYMKTGHKQVVQSFSIFPVFRVCQMFAVILKDFVENYSNRPVDRVFTTLIGYCMFTFLGISYLNRKQFLFNDPQIRNVELAFREVLRQCGSIAKFGIIFSIELVVFPIFCGILLSMCLIGTFKKLAAENLLNVMTVYPAQSIFLAWFIGITFMFEFAVFISMVRKIVRPGVLYFLRDPNDPQFHPIREILEKPMLFQLKKIGFSAILYFAFIIGCVGSVIHLLKSTGIIFPIEFTTKPAVFEAPIDLLALEILIFLSIKLFKPLELTRSFWRTLVSTFCRCLRLSSYVMGQRYSDEEGYYPKQYFSFLRRIISKPSDTENQDDGDKQKAKKDFVQDGFFLWCPSKDVVPVRQGAMLIPVTENGYEIFGEKKKVEENADYTITYAPSNFYKRLIALLLFCWICSTLVTVLLVFVPLSLGRAIYAWCFPNVVKHDFYAYAIGFYSISFPMYAIHASVKFLKLDYLRSLMNKLNLKIVMRSLVMALKYLLLAFLGIFILPLLLGAIWELYVAIPFRTIFNRGTLALDAFQNWVIGLFMLRMIYFTVTSNEERFVSRLFQDAFRDRWTNPQILPLLKNVLIPFTSALIAAVVLPSVFTYVTYPFLSSIFPSASKTLMYRLMHPIFLALLGLALLGRRFVETSSKWSQGIRDDLYLVGTRLHNFGESAPPAISESAEK
The following text describes a protein:
Function:
Converts the D-glycero-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position.
Subcellular Localization:
Cytoplasm.
Sequence:
MPRPAVFLDRDGVLNQEVGYIHRLEDLQLIPGVAQAVRRLNDAGWFCCLASNQSGPARDYYSIDHVHALHHRLQELLAASAGAVLDAVYFCPDLSRPEGGVVADYAGWTTWRKPNTGMLVAAAWDHDLDLSRSVMVGDKATDIDLARNAGCYGILVQTGFGDRVLEGSYQHASQPDYIAEDLAAAVEWICTHLAPR
The following text describes a protein:
Function:
As the catalytic component of the DNA polymerase gamma complex is involved in the replication of mitochondrial DNA (mtDNA). Has both 5'-3' DNA polymerase and a highly mispair-specific 3'-5' exonuclease activity. At the end of mtDNA replication DNA ends are ligated to produce a closed circular mtDNA molecule, its exonuclease activity is required for formation of these ligatable ends by preventing DNA synthesis from continuing past the 5'-end of downstream DNA into duplex DNA regions. Does not possess DNA primase activity, does not catalyze strand displacement synthesis and does not contain a 5'-3' exonuclease activity to catalyze nick translation. Important for promoting the elimination of paternal mitochondrial DNA during spermatogenesis, however its exact role in this function has not yet been identified and appears to be independent of its 3'-5'-exonuclease activity and only partially dependent on its DNA polymerase activity.
Subcellular Localization:
Mitochondrion. Note=In sperm, detected in puncta that associate with mitochondrial nucleoids at developmental stages when the nucleoids are being eliminated.
Sequence:
MQFHLIRKYASKVSREHYASSSVKIFRRVKPPQKVNKPKKPENVENGPTEYAENLVKVQMISRNLHAQLFPQAPRSISEQQVASAKVYKDELRRHGVDIESSAPVSDVQLKLPALRGANIEEHFHNIAKEQVQPYEELLLPLVQCEQLPKRPKRWAFHTGWTAYDPEDGTATPVDHPLEKGLVFDVEVCVSEGQAPVLATAVSTKRWYSWVSSKLTKHRLSVEKLEPLDVDTDSERPHYTTDELIPLGTTGPGLVVGHNVSYDRARLKEQYLTEDTGTRFVDTMSLHMCVSGVTSYQRAMLKSKKEPAAEDLGWLEQSSLNSLVEVHRLYCGGDTLSKEPRNIFVEGTLEQVRQSFQSLTNYCASDVEATHRILRVLYPLYAERFPHPASLAGMLEMGSAYLPVNSNWERYIREAQLTYEDLSIEAKYHLGRRAEEACSLLLDDQYRQNLWLWDEDWSVQELKLKQPPKRKPLPTVELKDSGNTPEERRLQAKFQHLYDQQALLPARRPLLPGYPLWYRKLCRKPPAKRADEILEDDEEPWSPGASEISTGMQIAPKLLSLCWEGYPLHYEREQGWGFLVPFRSDSEGVDRLPMEQLLAHCPVPEFARLSASKAESDMAFDMLPGQVEQHLGKREHYKKLSQKQQRLETQYQGSGVWCNKVLDDCCFFLKLPHKNGPSFRVGNPLSKDFLNKFAENVLSSGDPSCQAAARVIDIARMMSYWRNNRDRIMGQMVVWLDSQQLPNEFTGEKCQPIAYGAICPQVVACGTLTRRAMEPTWMTASNSRPDRLGSELRSMVQAPPGYRLVGADVDSQELWIASVLGDAYACGEHGATPLGWMTLSGSKSNGSDMHSITAKAVGISRDHAKVINYARIYGAGQLFAETLLRQFNPTFSASEAKAKAMKMFSITKGKRVYRLREEFHDELEDRAYSSYEASRLAIQRNRTLAEVFHRPNWQGGTESAMFNRLEEIATGSQPRTPFLGGRLSRALEADTGPEQEQRFLPTRINWVVQSGAVDFLHLMLVSMRWLMGSHVRFCLSFHDELRYLVKEELSPKAALAMHITNLMTRSFCVSRIGLQDLPMSVAFFSSVEVDTVLRKECTMDCKTPSNPHGLRIGYGIQPGQSLSVAEAIEKAGGNDVSQWDWIKKS
The following text describes a protein:
Function:
Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Domain:
Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate; Autoinhibited by its C-terminal basic region.
Sequence:
MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASITRVPFYDLVSTRKKKIASKQ
The following text describes a protein:
Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MNFPGMPGGAAPSGGAAPGGYDPNDPNIKMMQKAMESCFAKTVMSGGAGFALGGVFGMFMASMAYDTPYHSPTTPGTGPGANPAAAGIPGYKPVDLSSMPLKEQLKHGFKDMGQRSYSTAKNFAKVGALFSGIECGIEGLRAKNDLGNGVAAGCLTGAILAKNGGPQAAAVGCAGFAAFSAAIDAWMRMPSEED
The following text describes a protein:
Function:
Plays an essential role in the initiation and regulation of chromosomal replication. ATP-DnaA binds to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex once per cell cycle. Binds the DnaA box (a 9 base pair repeat at the origin) and separates the double-stranded (ds)DNA. Forms a right-handed helical filament on oriC DNA; dsDNA binds to the exterior of the filament while single-stranded (ss)DNA is stabiized in the filament's interior. The ATP-DnaA-oriC complex binds and stabilizes one strand of the AT-rich DNA unwinding element (DUE), permitting loading of DNA polymerase. After initiation quickly degrades to an ADP-DnaA complex that is not apt for DNA replication. Binds acidic phospholipids.
Subcellular Localization:
Cytoplasm.
Domain:
Domain I is involved in oligomerization and binding regulators, domain II is flexibile and of varying length in different bacteria, domain III forms the AAA+ region, while domain IV binds dsDNA.
Sequence:
MIESNHVVLWNRCLEVIKDNVPETTYNTWFAPIVPLKYEDKTLIVQIPSQFFYEILEEKFVDLLRKTLYKAIGEGTKLMYNVMVDKTSIPNQTVNLEASNRSTAVTPKSIVGGNKAPSFLKAPAVQDLDPHLNPNYNFENFIEGYSNKLSRSVAEAVAQNPAGTAFNPLFLYGASGVGKTHLANAIGTKIKELYADKRVLYVSAHLFQVQYTDSVRNNTTNDFINFYQTIDVLIIDDIQEFAGVTKTQNTFFHIFNHLHQNGKQLILTSDRAPVLLQGMEERLLTRFKWGMVAELEKPTVELRKNILRNKIHRDGLQFPPEVIDYIAENVNESVRDLEGIVIAIMARSTIFNKEIDLDLAQHIVHGVVHNETKAVTIDDILKVVCKHFDLEASAIHTKSRKREVVQARQIAMYLAKNYTDFSTSKIGKFIGNKDHATVLHACKTVKGQLEVDKSFQAEVQEIESLLKKKA
The following text describes a protein:
Function:
Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition. Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation. Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MENEKLGSISSHDILPFSYQGRLALWGLLGAEFPDSKHLCISNQWIPAPWNCEVFGGGCELGCSSATNTCTCPANHTIHSNRISCTPHPCAACTQECERQGDKYACSCKKGFRLGMDQKTCVDINECQEVSDLCANEGEECQNTLGSFHCSCMPDFVEEEGVCVNMSICLHCEHMNCEKVNGVYQCVCEDGFRVSPEDPTRCEEHCNSRDCKAECLPNTELEAKDMQQCYCPKGYITDNRNGTVICTDINECEQQKVCDHHCENLYGSYRCSCDDGFYLQDHGSCVPLDLEVGSGSDFPHLAPSNTPASLQPASVPSYIKAGSILGISVFMVLCVVLLGCLVRNMMRQCRTFTISSFKHPDIDLFYLQQVTAETYKRLSLDKQPRNDSQRLETTN
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
MEGEKEKKPKDRKEHLKEKNSIKTICPFNSEHIIKKKRLKKHIQACLDNPVNKPTYGKSYIIHNCNKIDTVEINTPLQIETFLPILNDEIFKSGIDKKRKGSEYVHCDCIHFSLSKLNIEVLKLLMTRVKRLYEFICKQYSTIVAPVSNNIEINNTIDYLLDQKTLEVEVPRYWGKPNQKMTVQCFSIIKHLIEKGILKNTSNCTQQIIETGAGTGQLSASYLLLPHENKNYVYLVDRMNASHKRFDRIGKYRGDEVKRIVADLCDFDPTELIKETMHNQPSGSVSIIGKHLCGSATDMVLRMAVRCSKQFKLNGIGIALCCHMKGDGHDDCMSDFFKSLGVSLLELTVIHRMSSWASSLRDLQEKQDDCIEINEAKSIGGDEEFQKDQRIIGEMCKTLLNVARVVWLKNQNVMQDVGLVKYCLQTITPENVLLWGVGK
The following text describes a protein:
Function:
As part of the MCIA complex, involved in the assembly of the mitochondrial complex I. Participates in constructing the membrane arm of complex I.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MVVFGYEAGTKPRDSGVVPVGTEEAPKVFKMAASMHGQPSPSLEDAKLRRPMVIEIIEKNFDYLRKEMTQNIYQMATFGTTAGFSGIFSNFLFRRCFKVKHDALKTYASLATLPFLSTVVTDKLFVIDALYSDNISKENCVFRSSLIGIVCGVFYPSSLAFTKNGRLATKYHTVPLPPKGRVLIHWMTLCQTQMKLMAIPLVFQIMFGILNGLYHYAVFEETLEKTIHEE