lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma-E controls the envelope stress response, responding to periplasmic protein stress, increased levels of periplasmic lipopolysaccharide (LPS) as well as heat shock and oxidative stress; it controls protein processing in the extracytoplasmic compartment (By similarity).
Subcellular Localization:
Cytoplasm. Note=Associates with the inner membrane via RseA.
Domain:
The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA, and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. The sigma-70 factor domain-2 mediates interaction with the RNA polymerase subunits RpoB and RpoC (By similarity); The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA. Interactions between sigma-70 factor domain-4 and anti-sigma factors prevents interaction of sigma factors with the RNA polymerase catalytic core (By similarity).
Sequence:
MAEQLTDQALVERVQQGDKKAFNLLVSRYQNKVAGLLTRYVSRNDIPDVVQESFIKAYRSIESFRGESAFYTWLYRIAVNTAKNYLTAQGRRPPNEDILAEDAENYDVGTHLRDVDTPENEMLSSELERIVFDTIHNLPEDLKTAITLRELEGLSYEDIAEIMDCPVGTVRSRIFRAREMIENKIQPLM
The following text describes a protein:
Function:
Functions as the terminal component of an NADH peroxidase (NADH:H(2)O(2) oxidoreductase) when using NADH:rubredoxin oxidoreductase (NROR) as the electron transport intermediary from NADH to RubY.
Sequence:
MKSLKGTKTAENLMKAFAGESQARNRYTFYSNTAKKEGYVQISNIFLETAENERMHAKRFFKFLSEGLDDEAVEINGASYPTTLGDTKKNLIAAAKGENEEWTDLYPSFAKTAEDEGFKGVAAAFRLIAAVEKEHEKRYNALLKNIEENKVFEKDEVKFWKCIKCGYIFEGKTAPKVCPACLHPQAYFEILSENY
The following text describes a protein:
Function:
Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B (By similarity). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin.
Miscellaneous:
MISCELLANEOUS: Vipar-deficient inner medullary collecting duct cells display abnormal expression of membrane proteins such as Ceacam5, structural and functional tight junction defects and reduced E-cadherin expression.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle. Early endosome. Recycling endosome. Late endosome. Note=Colocalizes in clusters with VPS33B at cytoplasmic organelles.
Sequence:
MNRTKGDEEEYWNSSKFKAFTFDDEDDELSQLKESKRAVNSLRDIVDDDDDDDLERVSWTGEPVGSISWSIKETAGSSGSTPEGREQLKGRNSFYTQLPKPPSTYSLSSFFRGRTRPGSFQSLSDALSDTPAKSYAPELGRPKGEYRDYSNDWSLSDTVQRLRRGKVCSLERFRSLQDKLQLLEEAVSMHDGNVITAVLIFLKRTLSKEILFRELEVRQVALRHLIHFLKEIGDQKLLLDLFRFLDRAEELALSHYREHLNIQDPEKRKEFLKTCIGLPFSAEDAAHVQDHYTLLERQIIIEANDRHLESSGQTDIFRKHPRKASILNMPLVTTLFYACFYHYTESEGTFSSPINLKKTFKIPDKQYVLTALAARAKLRAWNDVDALFTTKNWLGYTKKRAPIGFHRVVEILHKNSAPVQILQEYVNLVEDVDTKLNLATKFKCHDVVIDTCRDLKDRQQLLAYRSKVDKGSAEEEKIDAILSSSQIRWKN
The following text describes a protein:
Function:
Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC49 (Potential).
Sequence:
MQLGRKVTSHHDIDRFGVASTADESVYRPLPPRLRLAQVNLSRRRCRTQSDMYKSRFSECTVQSVDVSVTELRAHLSDWLDRARAGGEVVITERGIPIARLAALDSTDTLERLTAEGVIGKATAQRPVAAGRPRPRPQRPVSDRVSDQRR
The following text describes a protein:
Function:
Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors.
Subcellular Localization:
Cytoplasm.
Sequence:
MKTLADALKEFEVLSFEIDEQALAFDVDNIEMVIEKSDITPVPKSRHFVEGVINLRGRIIPVVNLAKILGISFDEQKMKSIIVARTKDVEVGFLVDRVLGVLRITENQLDLTNVSDKFGKKSKGLVKTDGRLIIYLDIDKIIEEITVKEGV
The following text describes a protein:
Function:
Required for keeping the ATP levels stable and balancing the aerobic respiration pathways during seed germination at low temperature.
Subcellular Localization:
Cytoplasm, cytoskeleton. Mitochondrion. Note=Associated with VDAC3 in mitochondrion.
Sequence:
MDQGAMETLPEKPSEDEFSLALRNGLILCNVLNKVNPGSVLKVVENPITPAIQYADGAAQSAIQYFENMRNFLKAVEDMQLLTFGASDLEKGGSSNKVVDCILCLKGFYEWKQAGGVGVWRYGGTVRIVSFNRKGSSPPQYGIGSESTTDESVSLDESESSQYDQLLDFLHLSNEISAEESETAISLAFLFDHFALQLLHGYLKESDGINDMPLNEMVIDTLLNRVVKDFSAILVSQGAQLGSFLRKILKCDNGDLSRSEFLAAVFRYLQHRKDLVSKEFSKFCKCGGKLEFSRLNAREFSPGHVEAIGLQQKELEEVKSNFVETRSQVKQMQSEWQKELQRIVHHVKAMEVTSSSYHKVLEENRLLYNEVQDLKGTIRVYCRVRPFFQEQKDMQSTVDYIGENGNIIINNPFKQEKDARKIFSFNKVFGQTVSQEQIYIDTQPVIRSVLDGFNVCIFAYGQTGSGKTYTMSGPDLMTETTWGVNYRALRDLFQLSNARTHVVTYEIGVQMIEIYNEQVRDLLVSDGSSRRLDIRNNSQLNGLNVPDANLIPVSNTRDVLDLMRIGQKNRAVGATALNERSSRSHSVLTVHVQGKELASGSILRGCLHLVDLAGSERVEKSEAVGERLKEAQHINKSLSALGDVIYALAQKSSHVPYRNSKLTQVLQDSLGGQAKTLMFVHINPEVNAVGETISTLKFAQRVASIELGAARSNKETGEIRDLKDEISSLKSAMEKKEAELEQLRSGSIRNTTECQRARAVSPFHLPRTGNGAGTKAEASPQPNDGTRSYETRSCSTGKQRKSGFPSALRNREASPRMPNLAEERLNPSPSRRSLSTDRASTIKSRNKPDVTQNLPVSRTPFPARVPVVKSFSTVPLNPSAENNHRLHTDNSSEAFQNHQKLSARKLFPEIEEEHIRHALHIRQGGVKKTRAESSKAKAKQPSPARFQKLDVGISLRSDADSEAKVGNYQTQKGNNNHNVIHSRFQNFDVGISLFSDLCAGDKSDSTLKSDSSETDNEPPSKSKNAQRNSSKNSLNHKLRTIYAHEDTSLVDDKPSNGTAHIKEGNNNISMPEFRRSRSTHHARFMVP
The following text describes a protein:
Function:
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Sequence:
MEAQNCIACLKSGPQGARVTIWDGQKLGRLNPAEKEDMRRVIDDMGRLSAQAQKLKVPITDYERIRLGSQALYLLTSSGPSKDVILVKGLLKVGQKNLFIRKECGALVEINPLCVLDFYVHVSCQRIGLGRQIFDAMLVHTKKLAYQIGYDRPSQKLLSFLAKHYNLKRFYPQANQFVIYNAYFDSSCPDDMRVQSRVCDCIRGNQKSCAVALLDSPRAKEIYHGRRVNKTPEPDIDIEPAPLPVSAKYTESSSDDKARDRPTTPSIPLRRRSVLQEDEVRVVPSVTQVFSELQGMDNHYDWMTGTKKPLLKPARSVAWKGVEFPSQDLSSTGLMDRGKLKSSSDVYDSLRLGSAKSPVPERLRRSKSPKSSHRAQLSGFGAAAALGFNQR
The following text describes a protein:
Function:
Plays a key role in hydrogen peroxide removal.
Sequence:
MTTTTASLVKTFLFRCDSFSSFKFKCKFESPAKTRLLSPATEKHVVRSSRAWRIRCLSDDPGSSHVFVASRRKMVVLLSTVQLLSHMLPQNGNAAEIYPVMQNEIRKVVTKGKAAGVLRLVFHDAGTFELDDHSGGINGSIAYELERPENIGLKKSLKVLAKAKVKVDEIQPVSWADMISVAGSEAVSICGGPTIPVVLGRLDSAQPDPEGKLPPETLSASGLKECFKRKGFSTQELVALSGAHTIGSKGFGDPTVFDNAYYKILLEKPWTSTSKMTSMVGLPSDHALVQDDECLRWVKRYAEDQDKFFEDFTNAYIKLVNSGAKWNML
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.
Subcellular Localization:
Mitochondrion.
Sequence:
MRQLRLFHGSGVRAWTVRGRLGTSRVRQELPQQPWCIRRASSLKAMSTSHEPTSTPTLTQASTPESTSNMHIANFNKIRSVPAEPRHKQEQNRLLGHVTQFKRHRELLTLAIETSCDDTCVALLQSYESTVRTETPEMVARLLFNKKITSDQRQFGGVHPAVAVEWHQRHLATLVEEAIRSLPEGKTPAYKNTRLPYRAPDLIAVTRGPGMPTSLATGMEVAKGLALAWGIPIVGVHHMQAHALTPQLVEALDRPPAPSVASSPWEERQQVDAEVKTASRQQEEAQHPNLDYPYLNLLVSGGHTQLVYSASLTSHLILCTTDNIALGDMLDKAARKILPPSMLNSGQNVMYAAALERFAFPRFPAGADEREYNFKYTPPATRAAEIEQHKSPYGWHLSPPLYASRKMEYNFTGLGSQAQRIAESLDISSSYENHTEHILSLENSPKSGSDLAPSPDSSTTILSPALKEEDHQIEQRRYLARATMQLAFEHLASRIVMVLQQQAKTSCEQQKVKTLVVSGGVASNQFLRHVLRRVLEVRGFGHIRIMAPPVNLCTDNAAMIAWTGSEMYRAGWVSKLDMLPIKKWSMSSTGEQGGILGTEEKPFYVRR
The following text describes a protein:
Function:
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process (By similarity).
Miscellaneous:
MISCELLANEOUS: Stress conditions rapidly and substantially elevates the amount of SUMO1 and SUMO2 conjugates with a concomitant reduction in the amount of free SUMO proteins. The SUMO conjugation system plays an important function in stress protection and/or repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MVSSTDTISASFVSKKSRSPETSPHMKVTLKVKNQQGAEDLYKIGTHAHLKKLMSAYCTKRNLDYSSVRFVYNGREIKARQTPAQLHMEEEDEICMVMELGGGGPYTP
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MSSIDQARKTIKALNSTYKIVHVTELATLGKLSALREKAEAAVSYYETILKSLRWVRKTMYTSNNQIKEEKNVTAIAITSERGLCGAYNSEVFAEIDQLIESLGDQVTINWVVVGEQGHRYLTKLGQNITSYLQFSLENIDLETTTAVTADFIDLIHSEQMDALYVIFTKYLNAVQSEAMCEKIYPEIPEDSDTELIEVDYVLDFETDDEQVEQLLLENYLCGLLYSMFRYSVASEYCMRRIAMKQAKDNIQKQLEEAIFDARKQALQQKTGELLDIISGAQTIRKDEE
The following text describes a protein:
Function:
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
Sequence:
MMSQISLADLNAADKADFVAALANVVEYSPWIAEKLAGQRPFTGINQLHAALMAAIQSAEPDVQLALIRAHPDLANKTQRAAGLTAESTDEQNSAGLDRLSDAEYAAFERVNNAYREKFGFPYIVCVRRHTKDSVLRDFETRLLNIAKTETRRAIEEIGRISALRLDQLVVADDKLKVHGRLSTHVLDNHAGKPAPGIPVELIELASLGESRVIARTVTNADGRTDQPLIGGRPLPIGRYELRFRVAKYYAERNVPLSEPPFLDEIPLRFAISEPENHYHVPLLVTPWSYATYRGS
The following text describes a protein:
Function:
Exports L-alanine.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MFSPQSRLRHAVADTFAMVVYCSVVNMCIEVFLSGMSFEQSFYSRLVAIPVNILIAWPYGMYRDLFMRAARKVSPSGWIKNLADILAYVTFQSPVYVAILLVVGADWHQIMAAVSSNIVVSMLMGAVYGYFLDYCRRLFKVSRYQQVKA
The following text describes a protein:
Function:
Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.
Subcellular Localization:
Cytoplasm.
Sequence:
MSQPRPLLSPPETEEQLLAQAQQLSGYTLGELAALVGLVTPENLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWIPVEGERSIPLAQRRVGSPLLWSPNEEEDRQLREDWEELMDMIVLGQVERITARHGEYLQIRPKAANAKALTEAIGARGERILTLPRGFYLKKNFTSALLARHFLIQ
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MARLRSRTATTEKDATESSKVPVPRRRRGQHEDTEEPDTYGLEDDEKSSGRPFRILEKLPCSAEPPRYDVLTHALSVRDSAVLYNSLLASRRTWIKAEMFELYWSKQYMNMKERERMLKEGIDPDDIDQSAAREKMHKLCDGILTGGPHTLPVRLFILKNDEIEQKWQFMQESRKKEKEVRRKREAEEKERRREERKRLQQLKKERKLKEVEHTKKEKIERKRENDTERDQLRKGRKDNKGPSVLSRMGTTIKSKGLTTFSKAQQQEIDNQKMIANLNLLAQRDPALNKLMIAVANGQAPPADVERFKVFIERARNMEPPPNWKPRLSSRPVIKRTEEPTVEQQESASQTPSTPLPRKASPESSQVDNLSSPPHGSDPNSSFTEASMSDSRGELSETKSGGSLVPDSTGSSGQALDKGPTDASGSANDLSRPGATLSSTDGAPPLKQETIPVRDMGDKNADKPLEAHGAISEKGTTITIKAEEGTAPRQKRKYTKRKKEVEDEDKSMQLTTFQQKYLNGADILFEYLENSNMRFLFPKDAILEQLENEESYLMSWIVVHNKKEIEQFKLKVLKGLNKNKPNEEETEVQPCLFNVYEHPNCPEVLYTPMTVTLSNIPKKFTPIILNSVNPAESVRAYMSTILARGRRLNGFNLWYQLDAYDDKDLAESLRCELKEYEQGFKSKRQKKQL
The following text describes a protein:
Function:
Component of the MIS complex, a complex that mediates N6-methyladenosine (m6A) methylation of meiotic mRNAs and is required for initiation of meiosis, progression through the meiotic divisions and sporulation.
Miscellaneous:
MISCELLANEOUS: Present with 3400 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Note=Localizes in the nucleolus during the period of m6A mRNA accumulation.
Sequence:
MNYMAYDYDPQHSLETSFNNLAFHPHQQSQQQALYESGERNDARPGLMNTLGQASKMNNSMLPQGSSASPLTGQHSLNSTTNFNMPPSMNTYNYQNVPQASMRNTLNHNNIMNGATANDYWLDPMNNMTNNKDTNGNPNDSMSSMSNMTAKTSINSTAFKNSFVPFNHVTALSMNNVNSNEMNSNKDDRMEALEVELQIKESQIESLENEIQRLKKIFNEGLNYKQNEHKYEKENCHIPQTFELPASLEVIFRKLSSSLHAKEKELAETKENLESILTALALNPTNSVTKYGRYDAESIAHKMVVRLENLTNENKEMAKMLAYGRSKETQIELQLAKKENLELREKIASLEAHLASKESSKEDVAN
The following text describes a protein:
Function:
Probable transcription factor. Involved in vulval organogenesis. During vulval development, may play a role in the regulation of cell cycle regulators such as cul-1. Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage. Plays a role in larval molting.
Subcellular Localization:
Nucleus.
Sequence:
MQTQSPFGPLLGISSSLLPSPVTVAAAAAAANGHQGPVSLTTFPSAFAAFASQIRNNQLQSLLQSQIQALNGGMGSPGNGPGTPLSRNNYAHHHQQHQNQQHVGKIRGTTEYPLRKRVGGSTVKTAKVWRYFDELPTIEQAAECRICRKKIKATNSSTTGMIRHLRSCHVQEYQLVQEARQNSMIVKMEEKARAKLLREMNEKVITNGIENTPIVKKESQTESQKSPSASSSASDTASSASSSHFSTNPLIGLPAPVAIKPPAPPTPSNSILNLSQSQNQCQNQNPMFQSQNIKNEPTDVEEEDLEQKRSRDILHRPSDLGTKMFFSSPRTFNLTSAFSSITPLEDHKFQKKIEDDHKIHMQIALMLLLDQQPCQIIDRPGIRSLFKFVLPEYHMPSGDVFQATIVPQLLNQMKQQIEALVHNSSSLSSIPDQVMTSSSATSSYEDVSVNESQMAGPNVGDEEEEIMEEEVEEDENVEIEDDTSSASSSIDTDTCDAMASFIHFIGNDAFPHDELISLLSVVTNLFTYFSTRPHVQTHLQMTIIQPTSQPLVQQVQFVTSNLSIISDYIRQTPDMQLLPLAVNQEAMLEKLVDHIDQLV
The following text describes a protein:
Function:
Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus membrane.
Sequence:
MVGDEQSDPELMQHLGASKRRALGNNFYEYYVDDPPRIVLDKLERRGFRVLSMTGVGQTLVWCLHKE
The following text describes a protein:
Function:
Promotes the exchange of Ras-bound GDP by GTP.
Sequence:
MSVFTFGHGSNGALGLGKITDDTCPTPQKVNYFTEIDKRVKKVACGSYHTVFVTDDEHLYICGIKKDPKHGTTLFYTSPPPTTTTTTTTTSSTSATTTTTNGMVNEKNNNNKNNNGEKIVNSKPESVIIKDGASNTTNDSTSSSSTSTSSLSSSLPPTNIETPRDKKKPPIKLDKGIPHHRSTRELIQRPESPLLNKLLTSKAEMEFKHYESNEKSKDEMKDNENENEEDEDDDDDDSTIRQNEDKESSLIDDNESETSLRINKKDAENITNNIRLIKELDEQQQQPQQPQQNLKGIMNQPPLPTNDDLDEDPNIHFTPIRISTHFLENSPLNTIKQVALGNYHIVLLTEGGNVWTWGSNSNGQLGYLVDTQQQQQQQLQQQQSMSSLQPSASSSSPSSSSLQTTCTPKMVEIKCVKYIATGVKNTAALTEWGELYMWGINEHGELGLGDTIDRRTPTRVIRLKNEVVSTIACSSTHSACYTESGKMYVWGQSDETGKIQAIPSPLPIHSYLDREIKSPNGGGVGGFFGGGGKIKQLACGQRCIAVLTQMGEVFMWEIPGIPIPLRNALENHSVRNIVMGNFHLVCLTDSGEVVTIGRNKTGQLGRTDAENEPGIVKQLSFDPDGLNSDEFVVSIAAGEFHSVALVENTPKTKLALQLVRMQRNYLRQLNILNNIYYKSMMSMASPYDPVVLSMMNNGSASTLPPSLKGLSGGLPDNANNTIKNGKDKDNHHNGDSNGHHSNGHYHGNGNNGNNSITTSNSISSPSLLGSGGTLKSRSASIATIRGLFGINHMLHHSQSQSFQEENSTVTEDEIKEIFSDIEALSKLTEKFLSYLDQRMDNWDPVSKVLGDIFLDEALMAAYRIYIPYSDSYNTSCMTLFNIRRRNERLSNIIKDCEKKSKSFGVKLDQEFVKEIDLKSLLLSPLQNIPRIYILLRELGSDDSGNINPRDIDLINFAATKFQVLLERMNQNFQFVNAVEILHCSSNEYGNPQIMGGSLPQLVDKLTHHNISDPNFRDVFLLTFRAFTTPCNLFDLLVETFQRQKHLKNGRVVNVITSWVVHHFYDFEKDKLSDFTQDPNHNPQLLSEKLEQFIYSEDHQSVSQIKLQYFSHRKRLESSINLIDNQKLTQNEITTPPPLQIQNNNQNNNLENNNNNNNNNNTTTTTTTPNDNINDINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNLTNSTIKLVVQPPIPINFNLLDSQPIEVAQTLTIMDHHYFAMIDKREFLGQRWAKNKSPNIQISTDHFNRTSQVVVTEILKSKNSKQRSATLGYFISVAYCCFELNNLSGTASIIYGLNSASIQRLKKSWSKLPKESMIAFEYLDKIVTPMKNYISLRHLMTTIQPPCVPFLGTYLKDLTFIEEGNPSIIGGLINFYKQRKIAEVIFQIQQHQQVVYSAIRSNPTIKAFLMSSHTFDDKQAQKISSEAE
The following text describes a protein:
Function:
Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (By similarity). Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.
Sequence:
MRRCPCRGSLSEAEAGALPAEARMGLEALRGGRRRQPGLQRPGPGAGGPTGRPEGGGPRAWIEESSLHSEAERTDLEPAPCPNGPQAESCGDGHAECEAAGLVVASEKPRQNKELDGSNLQTHPRRNSPLVEMEMAGSWTDGFRTDLHRSDLQSRPKRASLCTQPGFDESWTELDRSDMWQTLPERDNKPRVDNLRTHHGVSKLQTHPVCLSPESSADNSGKELSADASRTPHDTDGFWIESQTDDSLKGPSTQTACRQPGSDGFSSKDTESALTQPGTDGLRDDSVLGESNGNDPLDLSEPGELVTNLCSHLECSSLCPVPRLIITPETPEPEAQPVGPQSRIEGGTGGFSSASSFDESEDDLVAGGGGTSDPEDRAGSKPWKKLKTVLKYSPFVVSFHKHYYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLELLMGDPLRPFVPAYYGMVQRDGQAFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPKPRKDMYEKMVAVDPGAPTPEEHAQGAITKPRYMQWRETLSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVNGDLGILRKYVARLEDLRETLENSPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQMLSHRLPWTEGNREDGYLWGLDNLICLLQGLAQS
The following text describes a protein:
Function:
NAD(P)H oxidoreductase (By similarity). Involved in the ubiquinone biosynthetic pathway.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MTAAGFNSILCLRQLVRLNRRQYSAPAKSVLSGSQTNDQATPPPTSKSADKMRGWQLHNYGDIDELQLSEMLKIPQIRCSNECLVRIRATAVNPIDLAMLRGYGATVLNKMRCQPGDGIEFPLILGREFCGELVQTGMGVSLPLGSRVWGVVPLQATIGSHAEYVAVPSYCLAPAPKELDDYEAASVLYAGLTAWSGLYITGGLGGPCGATTASGGGAHKRVLVLGGSGGVGTLAIQILKSQKVQVLATCSENAIEMVRNLGADLVVDYNNPQAMEELCKYAPYDIVLDCAGQGGQKAAESKYDFRQYITFSSPLLANIDKQGLGVGALKNVFDLFQTNVRSVTQRGGLVKWGFFSPAPQGIQFLQKLVEQRKLMPLIDSSYGFSELPKAFEKMKSGHLRGKIVVKLREETGD
The following text describes a protein:
Function:
Required for centrosome duplication. Plays a central role in determining centrosome size.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosome throughout the cell cycle. Localizes to a tiny dot in the center of centrosome. Recruited to the centrosome once per cell cycle, at the time of organelle duplication and remains stably associated after.
Sequence:
MASDENIGADGEQKPSRPFLRKGQGTARFRMPRNNKTSAGAPPTSELSSASSPSINVPRFSLSNALPNSARTVDSGISNEDETRPPTTASLPMDQPSLSSSPENRLNPAPSVAEEHGHSGQHAEEEEDNDTDEVSAMPSFVPDEPSTLVNSDHELSDDALKYKNAAAEFKAFERRMDSMRSASTITTSLATPSSCAPSNSSEPPTRSTPIMNDLGVGPNNHNWPSSMQELSGISLETPQARPLGSNRINQLVRSEAQTGISLLQHHERPTVTAPLRRNDMMNSSRQNPQNGNVQDENRPEHVYDQPIHVPGSSLDRQKLEIEIRRHRNLNIQLRDTIAHLDYAEESVHTTKRQLEEKISEVNNFKKELIEEFKKCKKGVEEEFEKKFEKIKEDYDELYEKLKRDQRDLERDQKILKKGTGERNKEFTETIATLRDKLRASETKNAQYRQDIRVRDEKLKKKDEEIEKLQKDGNRLKSTLQTLEKRVKQLRTEKERDDKEKEMFAKVAMNRKTSNPVPPVLNQSVPISITSNGPSRHPSSSSLTTFRKPSTSNRERGVSWADEPNEQSLEAVPQEFLMMPVKEMPGKFGKCTIYRDSLGETSKVTDTIANGLLFEYSNGDLRWVNRQNAVNIYISAVDKTVRIDLPTYNISIIHTFQRQVEVLRPGNNITLISIKRREVRTDLIYQNGMYKTEIFNRDGRYVTKDFSNQEVSRKYNPGTHTYRDNQCRYVLVTDYNDFELVEPEFRLRWYQGDPTGLNNQYILKIIGRPECSEKTLRLEVNLSTCEGTLETAEMIGDKRRKTTLFQWKK
The following text describes a protein:
Function:
Has antibacterial activity against L.plantarum ATCC 8014. In purified form, the activity is bacteriostatic (IC(50)=2 nM) rather than bactericidal.
Subcellular Localization:
Secreted.
Sequence:
MSKLVKTLTISEISKAQNNGGKPAWCWYTLAMCGAGYDSGTCDYMYSHCFGIKHHSSGSSSYHC
The following text describes a protein:
Function:
Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress. Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway. ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR. May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability. Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver. Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth.
Subcellular Localization:
Nucleus. Cytoplasm. Cell membrane.
Domain:
The CARD domain may be involved in the regulation of caspase activity in the context of programmed cell death.
Sequence:
MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQVQVQVQVQQSPQQVSAQLSPQLTVHQPTEQPIQVQVQIQGQAPQSAAPSIQTPSLQSPSPSQLQAAQIQVQHVQAAQQIQAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVGALSPPPSQQGSPREGERRVGTASVLQPVKKRKVDMPITVSYAISGQPVATVLAIPQGQQQSYVSLRPDLLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRGDPQQQSITHIAIPQEAYNAVHVSGSPTALAAVKLEDDKEKMVGTTSVVKNSHEEVVQTLANSLFPAQFMNGNIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQQQTPQEQTPPPQQQQQQLQVTCSAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKNWAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYYVRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKNPSNPKDKSTSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQMLTRILVIREIQEAIAVANASTMH
The following text describes a protein:
Function:
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MHVFYSEERRGNLLILREGEVKHFRVRRIEKDEEFGVIHEGKIYVCKVRREDKREISCEIVEELETKLPPKDITLYQSVTVDLKTMDTIVRQATELGVLTFVPIISERSFQKEEAILKKTEKWKRIVIEAMKQSRRPIPMEIKKPVRLSDLIPESEENIILDNFYEGVKPKDVNLEAKTYSVVVGPEGGFSKRESQILREKGFKSVLLEPYTLRTETAVVSIVSILMNF
The following text describes a protein:
Function:
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
Sequence:
MITKEDVEHIGWLARIDINEQETVEYMEKLNSVLEYFGQLDELPTEDVAPTYHVAEIHNVFREDVVEECLSQETVLANTEHKQDGTFRVPKIG
The following text describes a protein:
Function:
Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MAALSCLLDSVRRDIKKVDRELRQLRCIDELSTRCLCDLYMHPYCCCDLHPYPYCLCYSKRSRSCGLCDLYPCCLCDVKLYCLRPSLRSLERKAIRAIEDEKRELAKLRRTTNRILASSCCSSNILGSVNVCGFEPDQVKVRVKDGKVCVSAERENRYDCLGSKKYSYMNICKEFSLPPCVDEKDVTYSYGLGSCVKIESPCYPCISPCSPCNPCNPCNPCSPCSPCSPCDPCNPCNPCYPCGSRFSCRKMIL
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAKKNKKEEPAEEKEEEEEVVEEEMELLQVDVGDVIKVKQILDETVAGTITGSEDLSAHGDKVKILEDYRHDNIKLFLMALACVFASIAQFGLNTDFPNNRLWLGVCCASYFCLSGILQLMMTFIDKDCIMTTRPVTDPEAIKAIKNGGNKEMDKYGIRVRTQFPRFSEFYTVILEFQGKENSEFVKGTWSVGHFFDVDGFFDEEGMQIEIEELYQRFEAGKFDKPEEETKGASKTKPSKKND