lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MLHSPHKQPQNHKCGANFLQEDSKEALVFKWLISAGHYQPPRPTESVSALSTVHAVIFKAASSIYNRGHKFYLEKKGGTMASNSLFSAVTPCQQSFFWNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFSDRLSDLGRI
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC1 and UBC7 E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD). Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). In ERAD-L, facilitates retrotranslocation of misfolded proteins from the ER lumen through the ER membrane in conjunction with DER1. Both proteins have lateral gates facing each other which form a channel through the ER membrane and which distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer. Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1. ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1. Ubiquitinated substrates are then removed to the cytosol via the action of the CDC48-NPL4-UFD1 ATPase complex and targeted to the proteasome. ERAD-M substrates are processed by the same HRD1-HRD3 core complex, but only a subset of the other components is required for ERAD-M.
Miscellaneous:
MISCELLANEOUS: Present with 2660 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MVPENRRKQLAIFVVVTYLLTFYCVYSATKTSVSFLQVTLKLNEGFNLMVLSIFILLNSTLLWQLLTKLLFGELRLIEHEHIFERLPFTIINTLFMSSLFHERYFFTVAFFGLLLLYLKVFHWILKDRLEALLQSINDSTTMKTLIFSRFSFNLVLLAVVDYQIITRCISSIYTNQKSDIESTSLYLIQVMEFTMLLIDLLNLFLQTCLNFWEFYRSQQSLSNENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVFTRFLKTALHLSMLIPFRMPMMLLKDVVWDILALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQNSANDDNICIICMDELIHSPNQQTWKNKNKKPKRLPCGHILHLSCLKNWMERSQTCPICRLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLTIENHEVNSLHGDGGEQIAKKIVIPDKFIQHI
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
Sequence:
MTQTSENVTWLTQEAYNKLKEELEYLTGPARTEISAKIAAAREEGDLRENGGYHAAKEEQGKQELRVRQLTQLLESAKVGEAPAADGVVAPGMVVTIAFDGDEDDTLTFLLASREYASSDIETYSPQSPLGSGVLGHKVGDDAQYELPNGKPASVRILKAEPYNG
The following text describes a protein:
Function:
[Stomagen]: Positively regulates stomatal density and patterning. Acts by competing with EPF2 (AC Q8LC53) for the same receptors, ERECTA (AC Q42371) and TMM (AC Q9SSD1). Not cleaved by the protease CRSP (AC Q9LNU1).
Subcellular Localization:
Secreted, extracellular space, apoplast. Secreted.
Domain:
The loop (82-95) connecting the two anti-parallel beta-strands (76-81 and 96-101) confers the function to the peptide.
Sequence:
MKHEMMNIKPRCITIFFLLFALLLGNYVVQASRPRSIENTVSLLPQVHLLNSRRRHMIGSTAPTCTYNECRGCRYKCRAEQVPVEGNDPINSAYHYRCVCHR
The following text describes a protein:
Function:
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. Promotes ubiquitination and degradation of SLBP. Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (By similarity). Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity).
Subcellular Localization:
Mitochondrion. Cytoplasm.
Sequence:
MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYSREVNTTEELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPEDLEAFIELH
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
Sequence:
MTQPPGQPVFIRLGPPPDEPNQFVVEGAPRSYPPDVLARLEVDAKEIIGRYPDRRSALLPLLHLVQGEDSYLTPAGLRFCADQLGLTGAEVSAVASFYTMYRRRPTGEYLVGVCTNTLCAVMGGDAIFDRLKEHLGVGHDETTSDGVVTLQHIECNAACDYAPVVMVNWEFFDNQTPESARELVDSLRSDTPKAPTRGAPLCGFRQTSRILAGLPDQRPDEGQGGPGAPTLAGLQVARKNDMQAPPTPGADE
The following text describes a protein:
Function:
May be involved in a process influencing telomere capping.
Subcellular Localization:
Cytoplasm.
Sequence:
MGQGTSAPQHLSEDQVSQLFAQQCYKTLEPIELYGLKDNFKATVLHQDHGDHVRMTDEEFAALLGIPSEFKSVEKLLTNSAKFLANFPFMDTKPREAGYSFNDLLKIIVFYSGRYTQVFKEFDPLKLLFVSLLKQCDVAKEVTLSEEPNLEFDGDWKSFGPVKQFYATDVSELKFPRDEFVDFLTFMLVLYGFDPSKGTVAKHIKTVVSQDKTDTKTLYADCRKSAQCISRACNGDIDLVQFRHAFDKVCPHLLAPVGHLFDLLLYTSAHSEKEDNEPVAPLNPLGSNSTYPTKLLNHATVAQMASFCPFLGNVENLKTLYMGQKDGFAQRSFESGTFGWRAPSVLLVSGLRLNTNNQSLKRANTFDEKYPRLKGAVVPDDGESEVKFGFYLDVPWRSSSKETFGSSKCFIFQLAPTQDIFVGETNPSNHAYFLKHDPGGLAFGSPIPKSIGRFTGVQAPQVVGTVSLTLDDSLEFGKFHHAGKGGSYAPSINRPGELMDERFKVRNVEVWGVGNDTDLEHQRKRIEWEEREASYRRTINKNNIAEDRAFLEMAGVIGGANRSGGSM
The following text describes a protein:
Function:
May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MLLFALLLAMELPLVAASATMRAQWTYSLRCHDCAVINDFNCPNIRVCPYHIRRCMTISIRINSRELLVYKNCTNNCTFVYAAEQPPEAPGKIFKTNSFYWVCCCNSMVCNAGGPTNLERDMLPDEVTEEELPEGTVRLGVSKLLLSFASIIVSNILP
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MKALMVRTDFSLGESALKAENAVKIARDAGYTAVISADSMNIASVIPLQRAAGDDMAVICGVKLNVVDDPTYEHRARLAKESERCMESLVRDRSYCFTALIKNEQGYRDVCELMTLANKREQFYFVPRLALDQLAAAYAKGNIILLTSDIGSVFQRRDFAKIIGTLVTAGGRDNFYSVVYPHPTPFYDQINVRAMKVASALKIEPVAFYPAYYEAVDDADIKDIAHMVTNNIKIDQPHRLRIPHQRDNAVNGRRHLLEALKAFSVRMDVPVTAAMASTTQDTIIEACTWRWHELPPALPKMADDEPATLMKLAVAGLRKRLTTKEFGYTPPASEHRVYVDRLKYEMDTLTRLGFCGYFLMVRDLMNHSRETGIPVGPGRGSSAGSLVAWCIGITNVDPIRHGLLFERFINPERLDLPDADLDFSQARRHEVIEYLNERYGEDYVAGIPNFTYLGAASALRDTARIYGVDAADMAVSKEFKNLEDDSLSLEELREQLASLDKYATKYPEAFKAACKLQSLMRGFGRHAAGMIVAGVPLVERTPVELRGNARCIAFDKRYCEAMGLIKLDVLGLATLDLLDSAKRYIKESTGEDINLDAIPLDDRKVLDGFAAGYTQGVFQLESGPMRKLLKDLGGGIEPMSFKTVVATTALFRPGPIQSGMLDDYVSVAKGFMAPQSLHPVLDELTAETNGVILYQEQTMNATRLLAGFTMAEADGVRKAIGKKDMEKMKSMGEKFVVQAQAGWIDVEMEDGTTQRIHRAEHFKCEDGALRTVEEALEAGVKLPMAAVRVTGSQPGLSETKAKEIWDAFEKNGAYQFNKSHPVAYSLISYQSMWLKTHYPAEFFAAALTILGEDKHQGLVKDALTYGIHVLPPDVNVSSNRIEIRTLEDGSQVLYAPFSAVKGCSENGCQAIMRAREKVGGKFESLEQFEEAVEKRACACNSRVRESLQKVGAFASIEPGSLPATDPERLRDQAELMGNLVIDAVKASRPFEMNPKRSAEVNVLMTRMAAEMGLGDDLIRPSIGIKPKIMVILDNANGNDGRTGYFMENGYDDFKAKLLTAGDLRMGDLYVTGVCKKVKDKEKDYTKDEIGQFTDFMREEINLVRPTYVLTCGSRATSLFNNKSKPSDLVGRKEYLPELDVTVFYGFNPNILYFRPEEGEKLEAILAEVAETISK
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.
Sequence:
MDVYDVSDDLIKKLQDWKLIGIISGKFNELKENHRKVDFVMRALIDFKYIEKIFLNVTLREDKCNKRSVEFRMLGNEQFSLKNRNYFQALELYNKSICYAEPNSEHLSIGYANRSAVLFEWKRYRQCLDNIKLARQANYPARLSHKLDKRERDCQQLLDQQPPDVVPYEFKLSFEPHAQVPFIADCLELRETAAEGRFVVTNRDLAVGDLVSVEEPFCSTLLTPMRYIRCATCKRENYLTLIPCDSCCSTMFCSEECKSIAMQTYHRYECPIIDFLNRMFNKIHCIALRTTLVALNIFPSIEELIDFCEQEQNQDKCAFDLNYNELTPEEHYRAIHGLVTNQHLRSVSDLFQRSVVCAVLKHFIIEYTPVKEYLGGEEGVNFFTDLLFRHLQTSPSNMHGIDLVEQVNETKDDQTHSSGAYAFLSLINHSCAPNTVRIYEGTKAYMFVLRPIKAGNVLYDNYGAHFAICSKEQRLKRLSLQYRFDCKCEGCELNYPMFGMMPHKATVPSVTDDTELALSSYNYDFAVSNYRKYCDFLTQYGDDYPCEQISSAEECLKMALHIMADAVPLKAKM
The following text describes a protein:
Function:
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
Sequence:
MALSEAEVRHVARLARIALSDEEIALMQAQLSAILDYIAMLQEVDVSNVPPTAQVTGLTTVWRPDVVGEMLTQEQALANAPDQQDGMFRVRAVFDE
The following text describes a protein:
Function:
Structural component of the distal part of the tail. Mediates T5 irreversible binding to its host entry receptor, the E.coli outer membrane ferrichrome transporter FhuA protein. Upon binding to host FhuA, pb5 undergoes conformational changes that are probably the key to the transmission of the signal through the tail to the capsid, triggering DNA release.
Miscellaneous:
MISCELLANEOUS: Only small regions of the protein may be involved in protein-protein interactions in the tail structure, the major part being used in receptor binding.
Subcellular Localization:
Virion. Note=Localizes at the tip of the central tail fiber.
Sequence:
MSFFAGKLNNKSILSLRRGSGGDTNQHINPDSQTIFHSDMSHVIITETHSTGLRLDQGAGDYYWSEMPSRVTQLHNNDPNRVVLTEIEFSDGSRHMLSGMSMGVGAKAYGIINPQIMSQGGLKTQITASADLSLDVGYFNTGTSGTIPQKLRDGTGCQHMFGAFSGRRGFASSAMYLGGAALYKSAWSGSGYVVADAGTLTIPSDYVRHPGARNFGFNAIYVRGRSCNRVLYGMEGPNYTTGGAVQGASSSGALNFTYNPSNPESPKYSVGFARADPTNYAYWESMGDPNDSANGPIGIYSEHLGIYPSKITWYVTNLVYNGSGYNIDGGLFNGNDIKLSPREFIIKGVNVNNTSWKFINFIEKNFNVGNRADFRDVGCNLSKDSPSTGISGIATFGLPTTESNNAPSIKGGNVGGLHANVVSIYNFLPSASWYVSSNPPKIGNNYGDVWSENLLPLRLLGGSGSTILSGNIVFQGNGSVHVGTVGLDLNSSRNGAIVCTMEFIDDTWLSAGGIGCFNPTEMLSQGAEYGDSRFRIGGNTINKKLHQILSLPAGEYVPFFTIKGTVVNACKLQAAAYNPTPYWVSGLPGSVGQTGYYTLTYYMRNDGNNNISIWLDSSMSNIIGMKACLPNIKLIIQRLT
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MDQFSGGGGNWSMIPNVQAQGNFGTPTNHDQQLFLQQQQLQQQQQQQQQQQFHLQQQQQTQQQQQQFQPQQQQEMQQYQQFQQQQHFIQQQQFQQQQRLLQSPPLQPQSLQSPPPQQTMVHTPQSMMHTPQQQQQLVQTPVQTPQQHQSLASHFHLYPMVEKLADVIENGTRDQNSDALVNELNSHFDKCQQLLNSISGSLGSKTMTVDGQKRNVEESEQLLQQRRDLIVEYRKSIEEIVTMEH
The following text describes a protein:
Function:
Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR.
Subcellular Localization:
Nucleus.
Sequence:
MELTSENSSENIPPAIRPCKTVVDQVKNTLSFLLTSAVNSIKKADSEKNEIPVEKSSSVDNPQILARKNKNLGDSPKVVSRSEKLRSKEAFQKRVKSFTLQNWCGKPLLLNPMLYAQYGWRCSGEDMVCCSSCGAVQCVQLPWPNATNYEEQCLKTRSKIVSGHMKVCSWSSSYCNDSFIIPFHPRYSNTQQQTCMLEEFQARAKKLLHLKNDLPLITDDVKEEMELSEKILVQLCAAADFNDNDDIENLMVVSSIILALSGWDTKSDGDSSNPGIFCNESSRLVGLWNFYSVGYLPNETDAPVAKKQKKDEDFTAIEKSYFHPLKQHHVWSPWVVTIKPMSADELSDERTSATYTDDDVLPGWKMLKNLICSDGLTTSKPTMKTPPRAAVKQARRILSEWSSPM
The following text describes a protein:
Function:
Promotes probably uncoating of clathrin-coated vesicles.
Subcellular Localization:
Cytoplasm.
Sequence:
MDDFTGLLARDFGLKPQGKSAPMASQSNSSAADFNTFASSYSFASAAGKKSDSLPVFDDLGRDGDDLLFRDVFSGPPPKYGSSGDSRSPSAPAFDYDVMFKEPKSKSASSMPVYDKPVYDDEDVFESIPELKIPSTSSQSARFENVFSSISSSPTKHRKQNSSPFDDLMGNNLGKKESDREEKGSSIFDDLIPGFGRTSSPPAKRTTSETTSQSQKPPYRTAETSSNVKEDPFVVLEESTSTLREPSTGGFTDPLEEIGKFNSRKTDHSSVHGGVFVDTDPLDSLGKSGPDMNSRGKSHLRPPGNISGSQSPVESSGLYHSKNVSFDDVVEPQNTSTPPPTNSDGSFESSDDVWLTVSEIPLFTQPTSAPPPTRPPPPRPTRPIKKKVNEPSIPTSAYHSHVPSSGRASVNSPTASQMDELDDFSIGRNQTAANGYPDPSSGEDSDVFSTAAASAAAMKDAMDKAEAKFRHAKERREKESLKASRSREGDHTENYDSRERELREKQVRLDRERAEREAEMEKTQAREREEREREQKRIERERERLLARQAVERATREARERAATEAHAKVQRAAVGKVTDARERAERAAVQRAHAEARERAAAGAREKAEKAAAEARERANAEVREKEAKVRAERAAVERAAAEARGRAAAQAKAKQQQENNNDLDSFFNSVSRPSSVPRQRTNPPDPFQDSWNKGGSFESSRPSSRVPSGPTENLRKASSATNIVDDLSSIFGAPASQSGGFQDVDGETEERRRARLERHQRTQERAAKALAEKNERDLQVQREQAEKDRIGGTLDVEIRRWGAGKEGNLRALLSTLQYVLWPECGWQPVSLTDLITGASVKKVYRKATLCIHPDKVQQKGANLQQKYIAEKVFDMLKEAWNKFNSEELF
The following text describes a protein:
Function:
Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
Sequence:
MLGACVSRWGLTGLPLRLLNSKTCCPTTQLYQSQANYSPNKCKDVEYKPIRSVLVANRGEIAIRVFRACSELGIRSVAIYSEQDKMQVHRQKADESYLVGKGLAPVAAYLSIPEIIRVAKENRVDAIHPGYGFLSERADFAQACVDSGIRFIGPSPRVVHQMGDKVAARQAAIEANVPIVPGTPGPVTTTEEAVNFCREYGLPVIFKAAYGGGGRGMRVVRKMEEVEELFQRATSEALAAFGNGAMFIEKFVERPRHIEVQILGDRAGNVVHLFERDCSVQRRHQKVVEIAPAPNLDPAVRERMTIDAVRLCQHVGYENAGTVEFLVDEAGRHYFIEVNARLQVEHTVTEEVTGIDLVQHQVKIAEGLTLPELGLDQSKIKIQGSAIQCRMTTEDPAKNFQPDTGRIEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLVKVIAHAGNLPASAAKMVRALREFRVRGVKTNIPFLLNVLENQKFLTGTLDTYFIDEHPELFQFVPSQNRAQKLLNYVGDVLVNGPLTPLGTDLKPADVEPKVPPVDSGRQLSGFREIITEQGPEAFAKAVRNHKGLLLMDTTFRDAHQSLLATRVRTHDLLKVSPYVAQNFSSLYSLENWGGATFDVAMRFLHECPWERLEEMRRVMPNIPFQMLLRGANAVGYTSYPDNVVYKFCELAVQTGMDIFRVFDSLNYLPNMMLGIDAVGKAGGVVEAAISYSGDISDPSRTKYTLPYYLDLADELVKAGTHVLCIKDMAGLLKPRAATMLIDGIRQRHPDVPIHVHTHDTSGAGVASMLAAAQAGADVVDVAVDSMSGMTSQPSMGAVVASLQGSELDTGISLESVSDYSAYWEQARTLYAPFECCVTMKSGNADVYLNEIPGGQYTNLQFQAYSLGLGNQFEDVKKAYREANQLLGDIIKVTPSSKTVGDLAQFMVQNKLSGQDVLDRAEELSFPKSVVEFMQGYLGIPYGGFPEPFRTRVLKGMPKVEGRPGASMPSMDLDKLKEDLIEAHGNQIRDVDVMSAAMYPSVCKEYLEFRSKYGPVDKFATRIFLTGPKVGEEFEVTIEKGKTLHIKTLAMAEDLTKTGDREVFFELNGQLRSVFIRDNTAAKELHIHPKAEKGVKGSVGAPMPGTVIDLRVKAGDKVEKGQPLVVLSAMKMEMVVQSPCTGTVKTVDIAKDMKLEGDDLLLTIEESK
The following text describes a protein:
Function:
Glucosyltransferase involved in the biosynthesis of the core oligosaccharide region of lipopolysaccharide (LPS). Catalyzes the addition of a second glucose (glucose II) to the first outer-core glucose (glucose I). In vitro, can add multiple glucose residues to its lipid acceptor. Activity does not require the branched galactose added by WaaB, but it is higher in the presence of this branched galactose. In the absence of a lipid acceptor, can hydrolyze UDP-glucose, but not UDP-galactose.
Domain:
Contains two DXD motifs that may play a crucial role in the catalytic function.
Sequence:
MQQVFFQETEFLNSVIDYDHKVETENLCLDIAYGTDKNFLFGCGISIASILKYNEGSRLCFHIFTDYFGDDDRKYFDALALQYKTRIKIYLINGDRLRSLPSTKNWTHAIYFRFVIADYFINKAPKVLYLDADIICQGTIEPLINFSFPDDKVAMVVTEGQADWWEKRAHSLGVAGIAKGYFNSGFLLINTAQWAAQQVSARAIAMLNEPEIIKKITHPDQDVLNMLLADKLIFADIKYNTQFSLNYQLKESFINPVTNDTIFIHYIGPTKPWHDWAWDYPVSQAFMEAKNASPWKNTALLKPNNSNQLRYSAKHMLKKHRYLKGFSNYLFYFIEKIKH
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS8 is required for the recruitment of protein phosphatase 2A (PP2A) to transcription pause-release checkpoint.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with chromatin and transcription pause-release checkpoint.
Domain:
The WFEF motif is required for the recruitment of protein phosphatase 2A (PP2A) to transcription pause-release checkpoint.
Sequence:
MSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKACPDPAPVQLIVQFLEQASKPSVNEQNQVQPPPDNKRNRVLKLLALKVAAHLKWDLDILEKSLSVPVLNMLLNELLCISKVPPGTKHVDMDLSALPPTTAMAILLYNRWAIRTIVQSSFPVKQAKPGPPQLNVMNQMQQEKELTENILKVLKEQAADCILVLEAALRLNKDLYVHTMRTLDLLAVEPGTVNGETENSTAGLKIRTEEMQCQVCYDLGAAYFQQGSTDSAIYENAREKFFRTKELLAEIGSLSLHCTIDEKRLAGYCQACDVLVPSSDNNSQQLTPYSQVHICLRSGSYQEVVQIFIEDNLTFTLPVQFRQSVLRELFQKAQQGNEALDEICFKICVCNTVRDVLEGRTISVQFNQLFLRPNKEKIDFLLEVCSRSINVEKASDSLKGNMAAFLKNVCLGLEDLQYVFMISSHELFITLLKDEERKLLVDQMRKRSPRVNLCIKPVTSFYDIPASASVNIGQLEHQLILSVDPWRIRQILIELHGMTSERQFWTVSNKWEVPSVYSSVILGIKDNLTRDLVYILMAKGLHCSTVKDFPHSKQLFTACLELVTEFSPKLRQVMLNEMLLLDIRTHEAGVGQSGERPPSDLISRVRGYLEMRLPDIPLRQVVAEECVAFMLNWRENEYLTLQVPAFLFQNNPYVKLGQLLAATCKELPGPKESRRTAKDLWEVVVQICSVSNQHKRGNDGRVSLIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVKLHNVREDIVNDITAEHISIWPSSIPNLQSVDFEAVAITVKELVRYTLSINPNNHAWLIIQADIYFATNQHSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKAIGQTELNASNPEEVLQLAAQRRKKKFLQAMAKLYF
The following text describes a protein:
Function:
Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV.
Miscellaneous:
MISCELLANEOUS: Present with 721 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Mitochondrion intermembrane space. Note=Imported into the mitochondria via the mitochondrial MIA40-ERV1 machinery.
Domain:
The Cx9C/Cx10C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system and the subsequent transfer of disulfide bonds by dithiol/disulfide exchange reactions to the newly imported protein.
Sequence:
MGLFSFDGGKKESQPPNTRSQRKLCWESRDAFFQCLDKADILDAMDPKNSKSIKSHCKVENEKFEENCAHSWIKYFKEKRVIDFKREQTIKRIEQEAKQRERNQ
The following text describes a protein:
Function:
Involved in the caffeine degradation, which is the essential first step for assimilating the carbon and nitrogen in caffeine. Catalyzes the oxidation of NADH and transfers electrons to NdmA and NdmB, which catalyze the N-demethylation reactions.
Miscellaneous:
MISCELLANEOUS: It is probably a fusion between a ferredoxin and a reductase into a single ORF which encodes a functional reductase that is specifically coupled to NdmA and NdmB.
Sequence:
MNKLDVNQWFPIATTEDLPKRHVFHATLLGQEMAIWRDDSGSVNAWENRCPHRGLRLTLGANTGNELRCQYHGWTYESGTGGCTFVPAHRDAPPPNAARVNTFPVREKHGFIWTTLGQPPGEPISILDDAQLVNAVKTNLHSVVIDADIDGVVSVLRQNLSAFIDVFGAASAEDLHLKSMLQDRGILVTRSGSIAIHFYMQRSTISKCVVHAQVLTPGRPGYELQKNYSYAMNVIRRAAEAVATDLISITDISDQTIEKLEVVRENMTKAPPTHYICEVVTRTQETGDINSYWLKPIGYPLPAFSPGMHISITTPEGSIRQYSLVNGPDERESFIIGVKKEIQSRGGSRSMHEDVKVGTQLKVTLPRNGFPLVQTRKHPILVAGGIGITPILCMAQALDQQGSSYEIHYFARAFEHVPFQDRLTALGDRLNVHLGLGPDETRAKLPDIMEIHNAQDVDVYTCGPQPMIETVSAVALAHGIAEESIRFEFFSKKNDVPVSDEEYEVELKKTGQIFTVSPGSTLLQACLDNDVRIEASCEQGVCGTCITPVVSGDLEHHDTYLSKKERESGKWIMPCVSRCKSKKIVLDL
The following text describes a protein:
Function:
Catalyzes the 3-beta-hydroxylation of the inactive gibberellin precursors, leading to the formation of bioactive gibberellins. In vitro, converts the precursors GA20, GA5, GA44 and GA9 to the corresponding 3-beta-hydroxylated active products GA1, GA3, GA38 and GA4, respectively. Involved in the production of bioactive GA for vegetative growth and development. Controls the elongation of the vegetative shoot and plant height by the regulation of active gibberellin levels (Ref.7).
Miscellaneous:
MISCELLANEOUS: Plants silencing G3OX2 exhibit reduced plant height.
Sequence:
MPTPSHLKNPLCFDFRAARRVPETHAWPGLDDHPVVDGGGGGGEDAVPVVDVGAGDAAARVARAAEQWGAFLLVGHGVPAALLSRVEERVARVFSLPASEKMRAVRGPGEPCGYGSPPISSFFSKLMWSEGYTFSPSSLRSELRRLWPKSGDDYLLFCDVMEEFHKEMRRLADELLRLFLRALGLTGEEVAGVEAERRIGERMTATVHLNWYPRCPEPRRALGLIAHTDSGFFTFVLQSLVPGLQLFRRGPDRWVAVPAVAGAFVVNVGDLFHILTNGRFHSVYHRAVVNRDRDRVSLGYFLGPPPDAEVAPLPEAVPAGRSPAYRAVTWPEYMAVRKKAFATGGSALKMVSTDAAAAADEHDDVAAAADVHA
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MQQISLYAKISNSQLKICLHALASLTGMDPITILQHTMVWAPAQKYTPKILPGQGGQLDQYRIHVTNDNKNEDKEKIISYVQSKDSKEDIHNLANRQWHFQIMEMPEAGKQKTTSQSISSWSVKKGDSFQFLQSLAYKFQYEYWQKGFQFVYGNAVIQLTRIHILDQTTKNIKLLDPSKQWLVKVYIDVGHLTDIEALNKAVKELEKVKTELHGLMNLEIPDRNAFDTRIR