lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Membrane.
Sequence:
MTNNVFSRFRQAQAQSYRFRHTRFYFFISTLELFVFLLSRLRRSPHSASSYDFFLLGLLVKYNNNELCTKNFPFPFASKSSTYPKKLSAYKCGSDPFDDVESRFDIRIYHVSISFIILDREVTSQQDSSVWILVYEGLFIDFDDQISLYEWKVGA
The following text describes a protein:
Function:
Binds to all microtubule populations.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTSTNIFSGNFADKPSSRVLKPPGGGNSNIFGGADDTSNLNNQPTHKTLPQQIQATIEKPGQQQQQPTKCEENIVGTVVEGGLKEVGQAKSSEQHCIITCSSTNKCSDETRSFKNKLQGSFNPITGEPYAANGSKLSGESKPTSSISVRQPPGGASSKLW
The following text describes a protein:
Function:
NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics. Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function. Involved in the reduction of all-trans-retinal to all-trans-retinol. Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable. Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group. A dehydrogenase activity has not been detected so far. May play a role as tumor suppressor.
Subcellular Localization:
Endoplasmic reticulum membrane. Note=Bound to the endoplasmic reticulum membrane, possibly through a N-terminus anchor. The main bulk of the polypeptide chain was first reported to be facing toward the lumen of the endoplasmic reticulum. However, it was later shown to be facing the cytosol.
Sequence:
MSWELLLWLLALCALILPLVQLLRFLRADADLTLLWAEWQGRRPEWELTDMVVWVTGASSGIGEELAFQLSKLGVSLVLSARRAQELERVKRRCLENGNLKEKDILVLPLDLTDTSSHEAATKAVLQEFGKIDILVNNGGRSQRSLVLETNLDVFKELINLNYIGTVSLTKCVLPHMIERKQGKIVTVNSIAGIASVSLSSGYCASKHALRGFFNALHSELGQYPGITFCNVYPGPVQSDIVKNAFTEEVTKSMRNNIDQSYKMPTSRCVRLMLISMANDLKEVWISDHPVLLGAYIWQYMPTWAAWLNCKLGKERIQNFKNNLDPDLPYKFLKAKKD
The following text describes a protein:
Function:
Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Subcellular Localization:
Sarcoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome. Cell membrane, sarcolemma.
Sequence:
MTEITAEGNASITTTVIDNKNGSVPKSPGKVLKRTVTEDIVTTFSSPAAWLLVIALIITWSAVAIVMFDLVDYKNFSASSIAKIGSDPLKLVNDAVEETTDWIYGFFSLLSDIISSDGDEDDEDADEDIDKGEIEEPPLKRKEIQKEKAEKQEKPEKKIQTKVSHREKEKGKEKLKGEKPEKKATHKEKLEKKERTETKMAAKEDKKIKTKEKTEEKAKKEMKVGKQEKAKPAAAKAKETPKTTPKAREKDDKETPAVPKHEQKDQYAFCRYMIDMFVHGDLKPGQSPAVPPPSLTASRPALSTPSLEEKEKEEKKKVEKKVTSDTKKKEKGEAKKKSEKETVIDGKGKEPGKPPETKQTTTKLTTQAAATKDEKKEDSKKMKKPPEEKPKGKKQEKKEKHIEPAKTPKKEHPAPSEKHRKAKAEQAKEEIAPASTKKALHGKKEEKAKTVEQGKDVKPKLPQPQLKKEEKSEPQPKKEVKLETQLKKEEKSEPQVKKEAKLASSEKGQTRKQNITRPEQVIPHGKPEQKVPKQIKAITAEKTEKAERQEKYHPSIKTEGKPEVTDSGKKKIEKPEKESKVPPKQENLQVRNVTRAEKRGKISKDSKDAPAPKKDKDSKDVLHSKKDKEVTNNVSSPKKQKSPISFFQCVYLDGYNGYGFQFPVTPVQHSGENPGKSNSPGQKQQEQ
The following text describes a protein:
Function:
Glycinin is the major seed storage protein of soybean. Glycinin basic peptides (GBPs), and, to a lower extent, glycinin exhibit antibacterial activity against Gram-negative and Gram-positive bacteria (e.g. L.monocytogenes, B.subtilis, E.coli and S.enteritidis) by forming pores and aggregating in transmembranes, leading to membrane permeability and, eventually, cell death.
Subcellular Localization:
Endoplasmic reticulum. Protein storage vacuole. Note=Hexamers are assembled in the endoplasmic reticulum and later sorted to the protein storage vacuoles.
Sequence:
MAKLVFSLCFLLFSGCCFAFSSREQPQQNECQIQKLNALKPDNRIESEGGLIETWNPNNKPFQCAGVALSRCTLNRNALRRPSYTNGPQEIYIQQGKGIFGMIYPGCPSTFEEPQQPQQRGQSSRPQDRHQKIYNFREGDLIAVPTGVAWWMYNNEDTPVVAVSIIDTNSLENQLDQMPRRFYLAGNQEQEFLKYQQEQGGHQSQKGKHQQEEENEGGSILSGFTLEFLEHAFSVDKQIAKNLQGENEGEDKGAIVTVKGGLSVIKPPTDEQQQRPQEEEEEEEDEKPQCKGKDKHCQRPRGSQSKSRRNGIDETICTMRLRHNIGQTSSPDIYNPQAGSVTTATSLDFPALSWLRLSAEFGSLRKNAMFVPHYNLNANSIIYALNGRALIQVVNCNGERVFDGELQEGRVLIVPQNFVVAARSQSDNFEYVSFKTNDTPMIGTLAGANSLLNALPEEVIQHTFNLKSQQARQIKNNNPFKFLVPPQESQKRAVA
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MFHTNCATVVVVGNGPDDAQEELVNEAEISTEFDAWNELRLHPLLMKSIYKLGFKESTSILKARIPALAHQRKDVIGAAETESGKTRAFGLPALQRLLEEREKAAKMLEEKGEEAEKYAPKGHLRALIINPTRELALQVLMVASPSLKSNSLTLAMAAGSPLLTSEHSNRRKPNKRKRTRKGGEDEKLDSLKWNPLSQPKTTTLLPSSLALMNLTEGKPGKKLNSKKRKRSSANEEDSGDGDGDEDGRGVQKEEERNLKNEKGKKKKKKKKGKKIKTVEESVAG
The following text describes a protein:
Function:
Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan. Required for normal separation of daughter cells after cell division and for cell wall integrity (By similarity).
Subcellular Localization:
Secreted. Note=Localizes to the septa.
Sequence:
MRRTVRALATRVHGRVCAVPLVVGMLLATALYGGGPAAADPAAPDNLATLVAKVASADQKLQELGAAIQTQQETVNKAIVDVQAARDAAAAAQRELEAGQRGVADANAAIEAAQKRFDSFAAATYMNGPSRSYLTATDPADIVNTTATGQALIASSQQVMAKLQRARTEQVNRESAARLAKEKADQAARDAESSQDNAVAALKQAQQTFNAQQGELERLAAERAAAQAELDSVRKVSATGNAAPAAAPAAAPAPAAAPAPVPNSAPAPVPGAQPNPQAAAGNWDRAPSGPASSGQNWAVWDPTLPAIPSAFVSGDPIAIINAVLGIASTSAQVTADMGRSFLQKLGILPTPTGFTNGAIPRVYGREAVEYVIRRGMSQIGVPYSWGGGNAAGPSRGIDSGAGTVGFDCSGLMLYMFAGVGIKLDHYSGSQYNAGRKIPSSQMRRGDMIFYGPNASQHVAMYLGNGQMLEAPYTGSHVKVSPVRTSGMTPYVTRLIEY
The following text describes a protein:
Function:
Plays a role in erythroid differentiation. Involved in cell proliferation and tumor cell growth suppression. Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner.
Subcellular Localization:
Mitochondrion. Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MAGLLALLGPAGRVGARVRPRATWLLGATAPCAPPPLALALLPPRLDARLLRTARGDCRGHQDPSQATGTTGSSVSCTEEKKQSKSQQLKKIFQEYGTVGVSLHIGISLISLGIFYMVVSSGVDMPAILLKLGFKESLVQSKMAAGTSTFVVAYAIHKLFAPVRISITLVSVPLIVRYFRKVGFFKPPAAKP
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MIPWVISPYSFDGSVVRFEKLALLLKRKGLKSVILADRNFHAAVKFNTIMRKHGLIPVHGLWKDGRIFVARNREEFDSLVRYYNGETHEIEDIPVFQESELTPVRYLDASEKKASIFMRKIFGLDEDVQGFPEKCEDVADILNAEAYDLRVNHRFPTPPKNWNELLIKKAEPLGEEYISRLKRELEVIKRKGFTPYIYTVEKVVEIAKKMGIKVGPGRGSAVGSLVAYLCGITEVDPIKYDLLFERFLNEERQEPPDIDVDVEDRRRKDLIKELSKSFQVYQVSTFGNLTEKSLKNLINSVLPDASLEEKNEIYKTVYGLPHHPSVHAAGVVISENPLPLPTRTEEDIPITDYDMYDLQEIGVVKIDILGLKTLSFIKDFKKEIFDYSDEKTYHLISKGKTLGVFQLEGLQARKLCRRISPRNMDELSILLALNRPGPLRSGLDVMFSNSKNVPAFFRKMFPETRGVLIYQEQIMRLAMFAGLSGTEADILRRAIAKKEREKMEPLLEKMKKGLLEKGMENAEQILEILLNFSSYAFNKSHSVAYAHITYQTAYLKAHHLEEFFKLYFAYNSSDAGKIFLAVQELRNEGYRVHPPDINISGKDLVFHGKDVYLPLTVVKGVGVTLVEQIEKIRPVSSVRELQERVTGVPRNVVESLITAGAFDKLYENRKLALEELNKRVEKDILEIRSLFGEKVEQESSNIKIGDITELEEKSMGFPLTPVHEVPTGLFARIDDVFTYGRILPVLVKRVSRNIVTDGLSVCRVRTDVPDGVHLVLLSPLQKIIKIWPFNENTRFVYRVDFTATLEKAGQNEITEVLKNGAVVRYEGYRPLTDEYRYRVVPR
The following text describes a protein:
Function:
[CLE10p]: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2.
Subcellular Localization:
[CLE10p]: Secreted, extracellular space.
Sequence:
MKTNRNRPINILIVFFLLTTARAATRNWTNRTHRTVPKVQHAYYAYPHRSCESFSRPYARSMCIELERIHRSSRQPLFSPPPPPTEIDQRYGVEKRLVPSGPNPLHN
The following text describes a protein:
Function:
Acts as a co-chaperone and mediates the association of the chaperones HSP70 and HSP90 probably facilitating substrate transfer from HSP70 to HSP90. Stimulates HSP70 ATPase activity and, in contrast, inhibits HSP90 ATPase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTAQQFKDLGNQAFKENKFEEAAKFYSQAIELNPNDHILYSNRSGSYASLSKYQEALTDADKCISINPNFAKGYQRKGLALHYLGEFEKAIEAYQQGLAKDPSNSLLQEGLKSAQTELQGTQNNPFASALKNPNILKLLGILQKDPRTSAFASDPTFMQLIGLMISQPQMASQFMQTDPRISTALSVILENPEAQAIFFSEFAGKVKKPDGEKKDHPQQQSQHMEEEQPQPQQEQHHHTHTDQHHQAHTEQHHQTHTEQPQQKQHHQPPPKPQPQLEEWEVQKNLGNDEYKNKNFEKALQYYNAALELNKEEALLYNNKAAVFIEQKLYDQALESIEEGLKVLEVHSSFQKKAKLLARKAKVLSLQNKVDEAIQIYEKSLVEDHVQSVKDELKKLQKMKQDLEAQNYINPQLGEEANTRGGDAFKAGKFPDAIQCYSDAIKRNPKEPKYYCNRATAYMKLMEFPNAVSDLEKCLSLDSKYVKAYVKKANCHFVMKEFHKAKTVYEKGLELEPNNVEMQQGLEKVRFSIMQGSGSEEEQQQRAKRAMQDPEIQQILREPEVINLLNDMKDHPQDGLKAIKSNPSLAAKIEKLIEAGVLKTG
The following text describes a protein:
Function:
Probable component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.
Subcellular Localization:
Nucleus, nuclear pore complex.
Domain:
Contains FG repeats.
Sequence:
MSLFGNTTTGGGGLFGNTTTPTQTTGGGLFGNTTTGGGLFGNTATPTTGGGGLFGNTATPTLTTGGGGGLFGNTTAPTTGGGGLFGNTPTQTTGGGLFGNTATGGGGLFGNTQQQQQQQQQQQQQQQQQQQQQPSTSLFSQSSLGSQSSLGSQSSLGSQSSLGSQSSLGSFGQTQQPQTSSLFGNLQQQQQLQQPQRSIIEQKLYDFMQSISPNSLNCRFLYWFYNYQANGQLVDPNSIPKPPNVTVDQWAYALSNNPDPSILIPVAAKSFDDLINRRMKQEETIIALDQNTQEALKRMRDLENHLNFHIHTQLEMMRKKQIELIQRYIEVWSNLEIYQSKGKTFTTSEERIMKKIYELFEEINQPNSIKSKVEEISNQLKLGSMEKEKIKYEISPEAVEPLYNLLKNMTISIERITNELEIAVKDAQILKNELYQLKKC
The following text describes a protein:
Function:
Binds GSK-3 and prevents GSK-3-dependent phosphorylation. Regulates the stability of beta-catenin in embryos. Maternal GBP is required for dorsal-ventral axis formation.
Sequence:
MPCRKESFLLLEQSVTVGSGEVDTLVARIGEALQLNAQRTPTSCSMAYGALKPVSRAGPSCSCVRGRSTPYPVCTPRGAARHAQHHHHHSPRQQGTGGNKRLCGRGWGRCNCRKHAGTEEEDDPHELLQELLLSGNLIKEAVRRLHMAGESPDPPGSRRVSECTETTVQ
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Signal transducer of the phototropic response and photo-induced movements. Necessary for root phototropism. Involved in hypocotyl phototropism under high rate but not under low rate light. Regulates stomata opening. Seems to be not involved in chloroplast accumulation and translocation.
Domain:
The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.
Sequence:
MATEGKNPINMNSMSSSLARTGQWVFSQDIPTDVVVEVGEANFSLHKFMLVAKSNYIRKLIMESKDSDVTRINLSDIPGGPEIFEKAAKFCYGVNFEITVQNVAALHCAAEFLQMTDKYCDNNLAGRTQDFLSQVALSSLSGAIVVLKSCEILLPISRDLGIVRRCVDVVGAKACNEAMFPCRTPPNWWTEELCILDVDFFSDVVSSMKQRGVKPSSLASAIITYTEKSLRDLVRDHSGRGVKYSDPGDNESDERSQQRDLVQSIVSLLPSDKGLFPVNFLCSLLRCAVFLDTSLTCKNELEKRISVVLEHVSVDDLLIPSFTYDGERLLDLDSVRRIISAFVEKEKNVGVFNGGDFNRGVCSVSLQRVAKTVDSYLAEIATYGDLTISKFNAIANLVPKSARKSDDDLYRAIDIFLKAHPNLDEIEREKVCSSMDPLKLSYDARLHASQNKRLPVNIVLHALYYDQLKLRSGVAEQEERAVVVLPEALKTRSQLQADTTLAKENEALRSELMKMKMYVSDMQKNKNGAGASSSNSSSLVSSKKSKHTFFSSVSKKLGKLNPFKNGSKDTSHIDEDLGGVDITKPRRRRFSIS
The following text describes a protein:
Function:
Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in somatic and germ cells. Required for embryonic anterior-posterior axis formation. Negatively regulates ify-1 protein levels during meiosis I. Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion. Involved in regulating GABA neurotransmitter release at neuromuscular junctions in GABA motor neurons.
Domain:
The C-terminus is specifically required for completion of oocyte meiotic divisions.
Sequence:
MDFSIVKTQILNNRRTFRTPFKVSSMCFSSQNDLIALGSKTGEILLKRTSWKMIWKTNINMIQAVGTECKLDSSVSALHFSPDGRFLAAATSKGIIHLLDVETGKVRFSVKAASEKIAKLHWNCVREKPFISNLGEFTTRIKNVEAIEGAIELAETTPNISQEEIAFVYQRLDEDGSSFKHEDAHKESLERTLISTETFRESLQNTILLATDDMDSKIIVLVAGVFPYMEIDISDTLLQYNQSLLMLYDMHYSSAFGGVSFLATTYGPFLDCKQNELKPPGAEPKKDGQGCHTLLFNVKLNINSSLWDTALRYIRLLFGFNLYSISLETTKRNWEEQIDNLHSLFDTKTKAVKIGNVLLEMLLSGSTDAAGEAFLERGLGTDGLDKIELFATKHMPEVCRIARGQLSTSARNLCFQRCEFSTSLSRYAKFIQLKDDDSFLYDEDPPAYLSESNIWLNTLEEKINILDMKTRHLGIQCLTMMQELGHLVKWISMTKPFAKTMKVNALMKIKRMNIAKILLYIVRNFIPDPEAVKDIENRLFNLKELVSKQKKKDLEDKFDEVEYLYRLERIAEVERKKLIETFHEKFRFADLDDDDLTPLLFQELDHPIDIFTDSMMEQNDSSPFLEEDEGEPEQEEQKPDEEPEPEGEPQPACDLDRVGSFFEKELSQKALEVLPKCDETFDCVLNERGSRMNSIEIQKMGILRVLEDLAATLSSPQKIHCDKAGNQKKLEVSFIYEITSTPTHQGYQDAKISSVTPSYYKRHPFNQLSGMGRSIQVSVLQKNEFSSIVIVPTSDVLPEDENEVNDHVEKLKRCYEFEKIDVTVDKSSAENRPPGETDAMEVDSNELRIDVDLGPVVPEYDTLIELSQVHPLHHGELVLLGKFTSAQEGTGVMSQMMRSISSYPHEIPEDKDVFAKNSSEDGSSEIPIETLIIHPTIQLAAYLHDDGSKITIGDMKPEVPPIADYEEKTVRKTFRDYQRRRERYREDMGVMNMNDVQYDVLVQEAMDSGRDLTDNGESDEDEEDDDI
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSIRKAAPRRTHRERAQPSARSNLGLLEKHKDYVKRAKDFHKKEKALKILKEKATFRNPDEFYFGMVNAKTNKGVHTLQRTETFDHELKSLMKTQDQNYINYQRSINLKKIKRLQEDIHFVEEDKEESDKEDSEDNEKNSMSDFDEPEPVQPTKKLRKSGPSHTIFVDDKAQAKSFDSVSYFETVPELVNKPFNRLRKSTLEKVEIPSITPEDAAYIAKQKDAAAAELSTRMQREESLRKVQLELQLQKNLMGKGARKKIGVDSLGLPKYKWKSCRQK
The following text describes a protein:
Function:
May be an activator protein for the gylABX operon.
Sequence:
MLQTLQKAARALTLFTPMHPEWSVGDMAKALELPKSSVSELLSSLAEQNLLRRVGPGRYRLGWRLLELGQTLLKTTEFREEARAVMQEMVAAWGETMHLAVLEAGTVVYLEKLRGQQGLQVELSGIGVRLPAHCSGVGKVLLAHQPWPEVLRVVGDDQLYPFTANTITSLDALAEELAHVRQRGYAYDLEEVSIGLCCVAAPIRDYEGNVIAAISFSTPTHRFRKHREQYTRAIVEGAQRISERLGYYGGTSACKSTKLKSPSSVPAI
The following text describes a protein:
Function:
Proton-sensing G-protein coupled receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGKAMLRAGFADTNSSNMNESFARLHFAGGYLPSDSKDWRTIIPSLLMAVCLVGLVGNLCVIGILLHGVWKRKPSTIHSLILNLSLADFSLLLFSAPVRAAAYSKGVWDLGWFICKSSDWFTHVCMAAKSLTFVVVAKACFAYASDPAKQESIHSRTIWSVLAGIWVVASLLPLPEWLFSTTRRHAGVEMCLVDVPAVAEEFMSMFGKLYPLLVFCLPLLLAGVYFWRAYDQCKTRCTKTRNLRDQMRSKQLTVMLLSTAIISALLWLPEWIAWLWVWHVKAGGPMPPQGFIALSQVLMFFTSTANPLIFLVMSEEFKAGLKGLWKWMITRKPAVTSEVQEAPAGNTEALPGKAPSPETQTCILDTDGRGSPDDSKEKSGKVVAPILPDVEQFWHERDAVPSAQDNDPIPWEHEGQETEGCN
The following text describes a protein:
Function:
Required during somitogenesis for the formation of somite boundaries. Represses the expression of genes involved in somite segmentation by acting with the corepressor tle4 to down-regulate the transcriptional activity of tbx6. May act by regulating the activity of tle4. Represses transcription of delta2, thy1 and ripply2.2/bowline itself.
Subcellular Localization:
Nucleus.
Domain:
The ripply homology domain is required for transcriptional repression; The WRPW motif is required for binding to tle/groucho proteins and transcriptional repression.
Sequence:
MDNINTTIDICGAASGLPSPGDSNSKRLRHRKYLPQRWKCEPRGPARTETQRPQTLFWRPWLLKSHKPKTQAHPYARGLRENPQEQKPVEYNHPVRLFWPKSKLLDNTYQEAADLLRNFPVQATISLYNDSESDTDNEEDSSEEEQDSGFESE
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MGVMDLREKKSLSEVVMMSENNKKFCTDCKTTKTPLWRGGPAGPKSLCNACGIRYRKKRRAMLGLNKGPEKKKERSQSSHSSSTTTTTSSASVATTNVGDKKPSGQLNGLSESVKMRLYALGSEVFLQRSSSSSLLSGVVKKQRCQRRRKLGEEEQAAFSLMALSCGSVFFSPLFLSEMQMPFDLDYCSLEN
The following text describes a protein:
Function:
Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro.
Subcellular Localization:
Chromosome, centromere, kinetochore. Cytoplasm. Midbody.
Sequence:
MAHALPLPIPCPVQLGSLKGDSLEAQLHECVRQGNCGKVKKLLKKGTFVDAVNSMGQTSLFTAALLGLGKIVDVLLDYGSDPNHRCYDGSTPVHAAAFSGNQWVLSKLLDEGGDLRVHDEGGKNPQYWAMSAGKESSAQMLEFIQRCTFHMQAAIQNFPCDPVRKICSSKALVSSPSRFGGLVQGNADSPLGRFLKDEVNAAKNIYSFGFGKFYLAGSRHVGYLASLPIIGEKEVVQADDEPTFSYHVGPCMIMTNLMWGSSRVTVKELSFQPHQNCAKLRLADLLIAEQEHSSKLRHPHLLQLMSVCLSSDLEKTRLVYERVNFGSLYSILHERRAEFPVLRMETILHILLQINDALRFLHSRGFIHRTITSYAIQIVSSGEAKLCNMEYMIESKDGGEHSDLTRIPVPAQLYKWCSPEVILEKSVTVKSDIYSFCTVMQEALTETLPWKGIEDSVIKQLIISGQQLEADVRLPVPYYDIVKSGLESKQKNRSMTLQDIQYILKNDLKDLTKSQSCHADEMAKAQRPAVFADINICLSSTFSYRKRTLELNEKGITEADSSAAPRYPIFPEENNALVDLEAPTSLQLAAQENNHDAASETQMTCSVSDVDDSLCSFEMNEVFASCPDFHEDFLEEGAELSQTLKDKKRQQKEKDENVLGDLFLSPGMCCEEKPVYEEGSISESVAEYTTEEEEGKSEASDLNMLAQVRGDAGRRSTLSSNEHHISKCVLNLKIVQSMLQQAAESLCRTEEKLDKLEAVEKQRKLLQEVWTNQLSKQVFRDRPCNRSDDFYQNIDSPFSGAHAFLWKAVGPPSSDYIPPLVTCQSQGALRGDGFQTVSNVSEEMWAIQNEKWKCFHQRSKGTKENSQHDLSFSEVKSLDDQVDLDHKHLLPRVSVRCKKKFNFQYQRGSDSHSSASGSKEERWCYPKSASEIHSMKINEERRMMQPEWRTEVRQMARKVASGQLELIAPYLASDCTSESEVESIKEAFQHVTSRVQKGRDQREDRWRTGDNAEPWDGGCEDGSESEESDLESIFRSSGGGSCQSPSQDEQAESGLSVHKNSVTFQQIETVSRGHSRELPCSFSSYPSESEEFLTPDPDYFLPAAVEESSEPKKQMPEDAGSGIRVSGGKILFCGTAAQNSGNNTRGVNQLSHMPVASTEAAQEVISRELQEDSEEKDISVTDIQDLSSIPCKEENYYEDINCRSPGVSHAPPSVSTPISSEERIPVAFEKHRCCHEVVLDSSSCICQEVSSAVSRTFTTAYEEERSTEVLSSSPSVCSSGLNEPGGFSAVASSSRSTRKAPALAQAPVHLVDELPAPAQELLDEIECLKQQDSIARDSVEEGLCDCRVQKNDSDRIKMEGTEAKKEIEISEKCDCSVWTMETFNLAEETERAHSTLDDALERILYAVPADEQIQEQQQEDEEIQGCALGAASLRDPRDIGRKKGAEEGGARARSSEADGCAGSSEGKHSEGQKFRLWEQQSSASPFRVIVLDQNSSPT
The following text describes a protein:
Function:
Plays a central role in chromosome cohesion during meiosis I by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. Required for maintenance of centromeric cohesion before prophase II and correct segregation of chromatids during meiosis II. Has apparently no function in mitosis.
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Localizes to the centromere during meiosis I. REC8 is required for centromeric localization.
Sequence:
MTSTAAEGAGSGSLNPPHSNPSGDGGPRIRSPPGKGNKPVALADITNTGKPNAARSITVPDLVKENTKLLTLLNEKTKIIDLSRVEIYKLRLALQASKQQNLHLTQTNSQMLAEINTGKDRIKMLQHELSCTTALLKVKDSELDRKKNAGNVQQKGVKSQVLKTKASTVAVEAHHVGDSVTSGVEHHVVESQSAVSSNTVCQEPPQDGKQKRMPQRRRSSRLNQGSCEIRGVSQNTLHENPVVPVAPSTLSLEKQYGQTTGKHMKSLQNECSATVHEVIMASEFEKTEINELPQKTDLKEIPEACSSETEVQSHKIGDKAFNSKQNHLTGSQSSLSFNTVDTPEPPEDNTVKRCSKKRSSIEDVNAKLDTITSEPLRHEEKRKSRRKISARLNSVSSEHTDIVVETEHKDVIVSLAGSTSNVSMEQRTNQEQDGDCFSRKSNENQILGRRSLRRAAEKVVSYKEMPLNVKMRRP
The following text describes a protein:
Function:
Catalyzes the Fe(2+) and alpha-ketoglutarate-dependent oxidation of pentalenolactone D to pentalenolactone F in the biosynthesis of pentalenolactone antibiotic. Also able to catalyze the oxidation of pentalenolactone D to pentalenolactone E.
Sequence:
MEVTPIPGAPLGAVVHGARVTGDMDKTHLEEIWSALDTYLVLVLRGHETPSYEEFLAFGRRFGHIPKTGLTSGAHPEHNEILIVSNLVEDGRKIGVGDAEWMGWHTDYSFRPRVSQVGFLEAVEVPYSGGGETLFTDMYALYESLSPEERRRLHSFRVRHALRTGYEETIEEELQREVTLGEGADRIQPEDGTSTVHPLIARNPRTGRRSVYISTLNTERIVDLAPDDSRELLDGLLAHAGKPQYTYAHTWQPGDLVVWDQLGTVHAKQAFDPAERRVMRQVVSIFDDPAGPWRAEAAA
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MDPCECSKTGTCNCGGSCKCSNCACTSCKKASCCDCCPSGCSKCASXCVCKGHTCDTIC
The following text describes a protein:
Function:
Involved in the lipid remodeling steps of GPI-anchor maturation.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MVNSWEALYSGNYMKSKKANKKFEFKVFTETGLITDGTQQNDSDLKNKGGKPTVRVSNVGHALHVWLNGEYHAMMRRAHGHCQDPASVTFSVLSLAMHFHGWLSFIITLYYKDVDITKRLDYSSAIAVLGFSLIVSILRTFDVRVEAARVMVSAPLLALVTTHVLYINFYKLDYGWNMIVCVAMGVAQLFLWARWAVSRHPSNWKLWVVVIASGYFDVHSIWHLATVPLTILWWSFIRDDDEFRTSSLLKKSKTKAK
The following text describes a protein:
Function:
Catalyzes the glucosylation at the O-5 position of anthocyanidin 3-glucosides to form anthocyanidin 3,5-di-O-glucosides using UDP-glucose as sugar donor. Anthocyanidin 3,5-di-O-glucosides are molecules that are responsible for pigmentation. Also acts on anthocyanidin 3-O-(6-O-malonylglucoside). Much less active with hydroxycinnamoylglucose derivatives. No activity in the absence of the 3-O-glucoside group.
Sequence:
MATNSHIIAIPFPLQGHINPMVQLCNRLISKGIRVTLVTTFSISKTLQNRTDENTINIETVPDIDSTVNGGDENLDIYEVFIRNFRASITNGVPDIIRKHSSSGHHVKAVVYDSVIPWCLDIAKGNGLRGAVLFTQPCTVCSIFYHLHEGNLEISSDEVGFEVSLPGMPVMGLKDLPTLVYDMNSYPSLLRLLVEQFSTFENADWRLFNTFDKLEDEILKWMSNKYPIRTIGPTVPSMYADKRLKGNYDYGLSLFKPSTESCFQWLETKEDRSVIYVSFGSLADLTEKQMEELAWGLVETKRNFLWVVRETEQCKIPKDFVSERGLIVNWCTQLEVLSHRSVGCFFTHGGWNSTLEALCLGVALVVMPQWTDQTTNAKLIADVWRNGVRVKCDPNGIVSREEVVACVNEVMEGESGDVIRRNAVKWKEMAVEAVSEGGSSDTNIAEFAEEILRT
The following text describes a protein:
Function:
Negative regulator of transcription elongation.
Sequence:
MSEPEPRRSVRATKGQHKALEQLDQIDIPKKRGKKAAKKAVPEPEEPEEEIIRCVCGATEQDEDSGEPWIACDMCGAWQHNICMGMSQYSEDLPKEYFCELCKPENHQELLNGMKNGERPWEARRKAFEEEKAEKRRRGNKKKSKRVSDHKEESAQVSQKPKPSPVPEPKKDAKTAAGQKRKTTEPVPEKEPKQKVRKVTETQAPSLPSYKAPDDIAGKISELPELRQGAAKLLSKSLVHSIGVAEKKGVSIPSEGVSASAERLAIQIERAVHDSHQPTAYSGQMRTLSYNLKTNQDLTTGLLGGTLTPTMLASMTTEELATKELQKETAEMKARAEKQSIMITEDVPRIRKTHKGEEVIGDESFNLSTDVSSAPVRRPPQDTAEPPKKRVKEEGPERAAQGTASKRASRDLTVDTQKSPSTGNFDINKVFSSVRSPTQSHHRRPSAMSTSTGPGVDADVDRLLDDGTQSPPYSPKEEILDPDVVWKGNLVMNTIADFQVTAKHIGGAKLKESIGLEWDKLMPKTLTVCGRIDEQQAIVYLCSLRYSLPTDVVVVNLQPTSAASKPQFQRLVDYFVSKKRYGVIGDRGVANVRDTYLVPVLPGTGQYPEFMLNLADNHIPETRTEPMLLAVFVYRNDPDTIMRLHGTNDYNQVVANQSTKVHTSFANTPAPSSPALANLPPGHRPSLSTPAFSPTSPQGTFPNYPTPRHSSTPSQVPPQQQPQPTPPAQQHSVSQIQHPAVDQVQKQGEAIAREVLGSLITSPTVAFLLPQAHKMSRKEWEVIKKIYERDPKARDDLPYLSNVLERESTNAQAKAAQAQQQSQQHPVHQQHQNQQQQMHHQPHHQQHHPQHQVQQQQQQQQQQHLPQHPPQHQPHHQAHFQPQPQHQQQHQAHHPPHHQPQHQSQQQAHHQPHPPPPQHHQQPQQQQQHPPKHQAQHPPQHQPQHQAPAQQPQAAYPPQPASHHPQPPQHQQHQPPQPQHAQPHPQAQPQQAHPQHHQQYFTPPVRTTPIPPPPIPPVTSGSGGPIKQTPIPPPPIPHQAATAATGPPSA
The following text describes a protein:
Function:
One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MERSVQENTLHYTIGHVLIIARIFGVLPLAGINPNGKPENVRFRWFSPYILFFVVAFTFVIADFMLSTKIVLNDGLQLYTMGSLSFSVICIFCFGSFIKLSRRWPHIIRETALCERIFLKPCYANQEGLNFTRFLRRWALILLVAALCEHLTYVGSAAWSNYVQIRDCNLKVGFVENYFLRERQELFSVFEYRAWMVFFIEWNTMAMTFVWNFGDIFLFLMCRGLKIRFQQLHWRIRQNLGKPMAKEFWQEIRSDFLDLDSLLKLYDKELSGLILVCCAHNMYFICVQVYHSFQVKGAFMDELYFWFCLLYVISRLMNMMLAASSIPQEIKDISNTLYEVRSSPWCDELGRLSEMLRNETFALSGMGYFYVTRRLIFAMAGALMGYELVLFRQMQGAVVQKSICSRGPGSSMSIFFS