lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).
Miscellaneous:
MISCELLANEOUS: The intein is a split intein capable of protein trans-splicing. The N- and C-terminal halves of dnaE are encoded by two separate genes located 745 kb apart in the genome and on opposite DNA strands. The dnaE-N product consists of a N-extein sequence followed by a 123-aa intein sequence (Ssp dnaE1), whereas the dnaE-C product consists of a 36-aa intein sequence (Ssp dnaE2) followed by a C-extein sequence. The N- and C-extein sequences together reconstitute a complete DnaE sequence that is interrupted by the intein sequences inside the beta- and tau-binding domains.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFVGLHIHSDYSLLDGASQLPALIDRAIELGMPAIALTDHGVMYGAVELLKVCRGKPIKPIIGNEMYVINGDIEINKRHRRFHQVVLAKNNQGYRNLVKLTTISNLKGIQGSGIFARPCINKELLEQYKEGLIVTSACLGGEVPQAILKGDLDHARQVAKWYKNLFGDDYYLEIQDHGSVEDRLVNINLVKIAQELDIKIVATNDSHFISCNDVEAHDALLCIQTGKLITEEKRLRYSGTEYLKSAEEMHLLFRDHLPDDIIETAIANTLEVADKVEAYSILGEPRIPHYPIPPNHTPETYVEDIAWDGLLERLKCRERADITPVYKERLEYELRMLEKMGFCTYFLVVWDYIKYARDHGIPVGPGRGSAAGSLVAYCMKITNIDPVHHGLIFERFLNPERKSMPDVDTDFCIDRRDEMIEYVTQKYGEDKVAQIITFNRMTSKAVLKDVARVLDIPYAESDKMAKMIPVSRGKPAKLKVMISDQTPEPQFKARYDNEPWVKKWIDMAIRIEGTNKTFGVHAAGVVISSEPLDQIVPLQKNNDGAVITQYYMEDVEAMGLLKMDFLGLKNLTTLQRAVELVAETKGIELDLDDLPLQERKALQIRARTGSKKLPDDVKKTHKLLEAGDLEGIFQLESQGMKQIVRDLKPSGIEDISSILALYRPGPLDAGLIPIFINRKHGREEISYQHKLLEPILNETYGVLVYQEQIMKMAQDLADYSLGEADLLRRAMGKKKAEEMQKHRAKFVDGSTKHGVPSRIAENLFDQMVKFAEYCLSFGTEILTVEYGPLPIGKIVSEEINCSVYSVDPEGRVYTQAIAQWHDRGEQEVLEYELEDGSVIRATSDHRFLTTDYQLLAIEEIFARQLDLLTLENIKQTEEALDNHRLPFPLLDAGTIKMVKVIGRRSLGVQRIFDIGLPQDHNFLLANGAIAANCFNKSHSTAYAYVTYQTAYLKANYPVEYMAALLTASSDSQEKVEKYRENCQKMGITVEPPDINRSQRHFTPLGEAILFGLSAVRNLGEGAIEQIITARDNSEEKRFKSLADFCTQVDLRVVNRRAIETLIMAGAFDGVQSNRNQLLHDLELVIAWAQKRAKEKETGQLNIFDSLTAGESIKAKEAANNGFEQEPSAPPVAEFSLQEKLQLEKEHLGFYVSEHPLKSVQRSARLLSPINLVDLDQYKVRQKVSAVAILVAVKKIITKKNGQPMAFLTLEDMSGQSEAVVFPSNYERLQDVLIEGSQQMIWGKVDRRDDQYQLIVEDLEPVEEVKMVMLDLTPQEIANTSTQARLKQILQSHAPQKEQMKIPVVACINEGPTKHFIRFGENYWVNDYGTAVASLQELGFRARLEPLLPQSQSVG
The following text describes a protein:
Function:
Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane. Involved in a step coupling MSS51-dependent cotranslational insertion of COX1 to the addition of its heme A and copper B cofactors.
Miscellaneous:
MISCELLANEOUS: Present with 1680 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MMLRLVTKGLPKVTPSAAKAVLVRGSLLHSFSTSARFNNSVAEDEAKIVLKDKNRPLRIDRELPDPTTERRKRIAGFLLFSVAIGSALSLIFNYEKTESPIISNTLYYIRRSPATKNILGESIEFDGIIPWVYGELNSVKGRINITFYIKGDKNVTGTVRLVADRNTHDEEFLIHEWSVTAAGQKIDLLAENTKTPI
The following text describes a protein:
Function:
Catalyzes the biosynthesis of agmatine from arginine.
Sequence:
MRYDVEQPSKLDRVRADYNVHYWSQGFFGIDDQGEVYVSPRKDKAHQTQLSSIVKQLEARDLNLPVLVRFPQILHQRVHNICDAFNQAIEEYDYPNKYLLVYPIKVNQQKEVVDEILASQAELEHKQLGLEAGSKPELLAVLAMAQQASSVIVCNGYKDREYIRLALIGEKLGHKVFIVLEKLSELDLVLKEAKSLGVKPRLGLRIRLASQGAGKWQSSGGEKSKFGLAASQVLTVINRLKAENQLEALQLVHFHLGSQMANIRDVRNGVNEAVRFYCELRELGAHIDFFDVGGGLAVDYDGTRSQSSNSMNYGLHEYARNIVSTVSDVCNLYGQPRPVIISESGRSITAHHAVLITNVIGTEAYSPEEIPAPGADAPMLLKNMWRGFEEVQHGTDDRALIEIYNDTQSDLSEAHSQFATGVLNLEHRAWAEQLSLRIYHELRQKMSNKNRFHRPILDELQERLADKFFVNFSLFQSLPDAWGIDQVFPVLPLSGLEEMNDRRAVMLDITCDSDGAVEQYVEGQGIESTLPVPAWTSDKPYLMGFFLVGAYQEILGDMHNLFGDTHSAVVNINDNGESEIAFINEGDTVEDMMRYVHIDVDKIRTNYRQLVSQRVAKEEQETVLAELELGLSGYTYLEDF
The following text describes a protein:
Function:
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
Sequence:
MKIALFGTSADPPTLAHRAILIWLAQHFDQVAVWAADNPFKQGPNPETGHWASLGDRQAMLKLLVEDVQKDYATVQIWEDLSDRRSLISLQRAQQRWGLEPDYALVVGADLIRQISQWYAVKELLPAVQLVIFPRPGYGINQADLDKLAQLGGHYQLVNQGDDQAITPPISSSIYRQIRDDDLIPDPVQSYIQQRQLYRQ
The following text describes a protein:
Function:
Involved in resistance response to the pathogenic fungus Alternaria brassicicola.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MAQRFYLLLLLLIFLVNLICFSSQQDLSFVFNGFNQDQAGDELLLDGFARIQSPERVLQLTDGTTQQKGHAFFNRPFDFGSASSQSLSFFTQFVCALVPKPGFYGGHGIAFVLSSAHNLKKAYASSYLGLFNRSTNGSPSSHVLAVELDTVQSAETDDMDNNHVGIDENRIQSVVSASASYYSDREGKNISLILLSGDPIQVWVDYEDTLLNVTLAPLRNQKPSKPLLSRTINLTAIFPDRKAFVGFSAATGSSISNQYILGWSFSRSRRLLKSLDISELSTVPLFTEQKRKRSPLLIVLLVILTLVVIGGLGGYYLYRRKKYAEVREPWEKEYGPLRYSYESLYKATKGFNKDGRLGKGGFGEVYKGSLPLVGDIAVKRLSHNAEQGMKQFVAEVVTMGSLQHKNLVPLLGYCRRKGELLLVSKYMEGGSVDQYLFNGDKPPLSWSQRLAILRDIASALCYLHTGASQVVLHRDIKASNVMFDDHGANLSATAAVGTIGYMALELISTGTSTKTDVYAFGAFMLEVTCGRRPFDPEMPVEKRHLVKWVCECWRKHSLVDAIDTRLRDKFTLGEVEMVLKLGLLCTSIIPESRPNMEKVMQYINRDQALPDFSPDTPGIGVSTPMVMGIPGLAITSTSVTSSASVPLVSPPSTNNSMFISHTILNGDGR
The following text describes a protein:
Function:
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
Sequence:
MFKIQEVRELIKLIDSSNIDEFEYKKDGTTIKMKKRGNEVVAVQAPAAKQAMQPVAPVEVETKVAAAQAEAPKQEEKKAVQNENLHKITSPMVGTFYSSSSPDTPPYVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLFLVKA
The following text describes a protein:
Function:
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MEYASDASLDPEAPWPPAPRARACRVLPWALVAGLLLLLLLAAACAVFLACPWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE
The following text describes a protein:
Function:
Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Sequence:
MGGGEETKTGEEEKLFDLNDYTIIKEGEAEILMHTKNEVFYNKTQVNNRDMSIAVLRTFISKRKEEHEALLSKRIKKVLKVSEDRDSGSDPPTDSPKPNGKPNGECEEKPDNEPCDTCAEPEKLPEGKGQGELKPPRVLEALSASGLRALRYAREVEGIGQVVALDNDKASVEACRRNIKFNGSVATAKVESNLADARVYMLTHPKEFDMVDLDPYGSPSVFLDSAVQSIADGGMLMCTATDMAVLCGGNGEVCYSKYGSYPLKAKYCHEMALRVLLACIESHANRYKRYIVPVLSVQMDFYVRVFVRIYTSAGAMKNTPLKLSYVYQCTGCDSFHLQPLGRTVSKNTSVRYLPGFGPVVPQECSDCGKKYNMGGPIWSAPIHDQDWVTSILSDVKSMKARYPAFDRISAVLTTISEELPDVPLFVSLHSLCATLKCTSPSAVVFRSAVINAGYRISGTHVNPLGLKSDAPMDVIWDIMRCWVKKYPVKAQPPEHSGSVILAKEPVLQANFARAVASLSKAQAKKVARFLPNPERHWGPKLRAGRTITSKHASLLGPETVNGILNNNEEQGEEPEAKQ
The following text describes a protein:
Function:
Catalyzes sulfur activation and mobilization in sulfur mobilization (SUF) pathway for iron-sulfur (Fe-S) cluster biogenesis. Active when in complex with a partner protein SufE. Required for apicoplast maintenance. Plays a role in the development of sporozoites in oocysts in mosquitoes (By similarity). May provide sulfur for MNMA-mediated tRNA modifications.
Miscellaneous:
MISCELLANEOUS: Dose-dependent inhibition of catalytic activity by d-cycloserine (DCS) was observed in the presence of SufE. Compounds related to DCS may therefore show antimalarial activity.
Subcellular Localization:
Plastid, apicoplast.
Sequence:
MLRGPRCLYIYLFFVFLPFSFCYIRNNDNRFVYIVKSIRKGPNIKLRLTKDEKPNIDNHIIDYFKNVREHFPFFKENKSLIYFDSAATTHKPSCVIEKMSEFYKKENSNIHRGIYKLSHNATNNYEKVRETIKEYINCEKNDNIIFTNGSTYGLNVVCKMMIEEIIKKEEDEIYLSYMEHHSNIIPWQEYINKEKKGRIKYVPLNKSGYINIKKLISNMNINTKVISICHASNVIGNIQNIEKIIKKIKNVYPHIIIIIDASQSFAHIKYDIKKMKKNKSCPDILITSGHKFCASLGTGFIFINKELSSKYKFKPLLYGSNIITNVSKYKSKFVTSLSELLETGTQNIPGILSMGISLEFFKKINWNYVYQYEMYLYDLFIYYMNKYMKNHFVQLPNLNLSYKKENINYKSHMQTHPPVHKYNDEQNFTNDHNITQSKQTKSIHSQHDTFKIYTHDTRKYGLKKIGILPLWSNTFSSFDLVTFLDFKNICIRAGHHCASLLHKYYLKVPDTSRISIYFYNTPQEIKYLAQQIASTSFMLNEMKNEK
The following text describes a protein:
Function:
May transport divalent cations (By similarity). May participate, with dstA, in the regulation of the differentiation of stalk cells during development.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDIVNDLVSSISSISSEAAEEEAIRDELRNDKGGLIAGIFVLTLTASFVPWFLTKAKITNLVSVVSILTCLSAGVIIGAGFNHILPDAAEEFQSYVEAVAPDNKYGDFPFAHTITIVTMFALICVDKILVSGGLDGEADHNHMDLSQHNHPSPHAAGEIDLNIYTNGDDDDDDVNEDQEEDSTKDDEKEHGHGHGHGHGHNSSNSSSNGHGHGLKKKKKSKKEHGHGHNHDHSSNGHSHKDEKDSEKVNVSSKSKAWVFLVALSLHSIFDGLGLGSETQKDSFYGLLIAVLAHKFLDGLVLGIAIKYAYFSFKFSCIALVFAAAMTPLGIGIGMAISSAYESSTDAYLVKGIILSITCGSFIYISLIELLPSGLCQKGWPKLKLAVAFLGYSVMAILALWV
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate VapC4 toxin. Upon expression in situ, in M.smegmatis or E.coli neutralizes the effect of cognate toxin VapC4.
Domain:
The C-terminal domain (residues 55-85) is sufficient to interact with and neutralize VapC4; exchanging the N-terminus (residues 1-54) with VapB5 allows neutralization, while exchanging the C-terminal domain (residues 55-85) does not. Many single residue mutations in the C-terminal domain construct but not in full-length protein prevent toxin neutralization, they are not all annotated here.
Sequence:
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTTDDVRW
The following text describes a protein:
Function:
Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAAPPDSQDELLPLTSPGSQWLGDRGEGEDEAVTPKGAQPAPQAGEPGSGLGAGAREASQLELGSGPARPPPVAMETASTGMADVSRATDHTFATAARDGGGVCYTSLISDICYPPREDSTYFTGILQKENGHIATSESPEEVRTTRPSFPDVPVTEPRGFFSSDSGIEMTPAESTKVSKILADPIDQMKAEACKYIDITRPEEVRDQEQCHPKAEEKDLDLKNKDTEISDQSEEAREAEKPTPVEGKILKDHLFEESTFALYVDDISEEQHSAPVVTAPVKITLTEIEPSVDTATPEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSVTPPSSGTEPSAAESQGKCSISEDELITAIKEAKGLSYETTESPRSAGQVVDRPEAKARSGLPTIPSPLDHEASSAESGDSEIELVSEDPLAAEDALPSGYVTFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPLMKPGALDAIREEPGARAEEHAPSQRGLVEFPSAIPQTGPKLPPGDGAPASEEPSLPPKPVETASSDQSSPATGVPGPLGPGVAPPLLFLNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE
The following text describes a protein:
Function:
Major urinary proteins (Mups) bind pheromones, and thus stabilize them to allow slow release into the air from urine marks. May protect pheromones from oxidation. May also act as pheromones themselves. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance (Probable). Binds the pheromone analog 2-sec-butyl-4,5-dihydrothiazole (SBT) in vitro.
Subcellular Localization:
Secreted.
Sequence:
MKMLLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIHVLENSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEEHGILRENIIDLSNANRCLQARE
The following text describes a protein:
Function:
Required for arbuscular mycorrhiza (AM) development during AM symbiosis with AM fungi (e.g. Glomeromycota intraradices).
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MRRRSPTSVPSEQMEKGTGKSQNTRICFLASLSVFFWMLLLYFHFVVLGGSTVDQSVKLQLQAGPVYTELKPTRVTSDPQKENQNTESKPIHVTSDHQMDNQNTVSAPIRLTDDHQVDNQNTESTPTVVAPAAHQTESPAKAIQIHEAEKYPFMKALRTAENKNDPCGGRYIYVHDLPPRFNEDMLKECRSLSLWTNMCKFTTNAGLGPPLENAEGVFGDTGWYATNQFAVDRPEWGIMGGKDHFLVAGRITWDFRRLSEEDSDWGNKLLFLPAAKNMSMLVVESSPWNANDFGIPYPTYFHPAKDADVFIWQERMRRLKRDWLFSFAGAPRPGNPKSIRGQIIDQCRNSKVGKLLECDFGESKCHSPSSIMQMFQSSLFCLQPQGDSYTRRSAFDSMLAGCIPVFFHPGSAYTQYTWHLPKDYTKYSVFIPENDIRKRNVSIEETLRRIPPEQVKKMREEVIKLIPSLVYADPRSKLGVFKDAFDVSVQAIINKVTKLRMDILEGRTDDNFIEENSWKYALLEEGQREVGPHEWDPFFSKPKDGEGDSADTKLRMFNIDKQPNPSSLSEFIFLCSILCMQTPSSPSPKNFFEFLTYIVQLHPQGVTSSSFATKPSWHLSFLQQTMSSEEDASSRLLYSYHSAMEGFAAQLSESELASLQMLPDVIAIRPDHRLQIHTTYSYKFLGLNTASSDGAWHKSAFGRGTIIGVLDTGVWPESPSFNDRGMPPVPRKWRGICQEGQNFNSSNCNKKLIGARFFTEGHRVASVSSYSPDAGHEYVSPRDSHGHGTHTSSTAGGASVGMASVFGNAAGVARGMAPGAHVAVYKVCWLNGCYSSDILAAMDVAIRDGVDILSLSLGGFPIPLFDDSIAIGSFRAVEHGISVVCAAGNGGPIQSSVANEAPWIATIGASTLDRRFPGIVQMGNGKYLYGESMYPGNHLMRAGKALELVYVTGENSGSEYCFRGSLPRAIVRGKIVVCDRGVNGRAEKGEVVKEAGGAAMILANTEINLEENSVDVHLLPATLIGFKESVHLKAYINSTRRPTARIVFGGTVIGKSRAPAVAQFSARGPSYSNPSILKPDVIAPGVNIIAAWPQNLGPTGLPEDSRRVNFTIMSGTSMACPHASGIAALLRSAHPKWSPAAIKSAVMTTAEVTDRSGKPIMDGDKPAGVFAIGAGHVNPERAIDPGLIYDIRPEEYVTHLCSLGYTKSEILTITHRNVSCREILQMNRGFNLNYPSISVTFKHGMRSKMIKRRVTNVGSPNSIYSLELMAPKEVKVKVKPQRLIFTDINQSLSYRVWFISRKRAGTAKMSFAQGQLTWVNSKNSLNRVKSPFSVTWK
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MGGTKKKWFSFHQRSASATTTTVPQHKHDETPPEFLCPITGFLMSDPVVVPSGQTFERLSVQVCRNVGYVPDLLDGTRPDFSTVIPNLAMKSTIFSWCDRNKVDHPRPPDSAYVENVVRARMNKDPQSRIGTQPSSALGDPEPEMLPPVAENSPSDYDAVMEAIRARSKNSVSSPTTSLESVTVGQSPYHPTRAVSMFSSFSTTSSRVYIGAESPNAISFSSSDYSSSSPMSPEEEEIFNKLRTADIFDHEQGLILLRKMTRTSEELRVSLCTDRILSFLRSLLVSRYNLVQTNAAASLVNLSLEKQNKVKIVRSGFVPLLIDVLKSGTTEAQEHVAGVLFSLALEDENKMVIGVLGAVEPLLHALRSSDSERARQDAALALYHLSLVPSNRTRLVRAGAVATLLSMVRSGESTSRILLVLCNLAACPDGKGAMLEGNAVAILVGKLREGGGDDSEAARENCVAVLLTLCQGNLRFRGLASEVGAEEVLKEVEERGNGRVKENAAKILQVMRGGGGGGSAFGENGEAREWNRMLEGTGLSRTQFQGGQNGGFACSSQF
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
DVEVTYEDQMKINSFARNNASLQDLKEELDLKKKSLQNLEDAESDVLMMDDSEETNIPYQIGEFFVCCNQSDVLLYIEKEKADLDKDIKEMENKADNFRKILADLKVQLYAKFGTNINLEAEDE
The following text describes a protein:
Function:
[CLELn]: Maintains the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT), mainly at the post-transcriptional level (By similarity). Promotes root elongation.
Miscellaneous:
MISCELLANEOUS: When applied in the extracellular space, triggers a root waving phenotype. But seems to have a physiological nuclear subcellular location where it promotes root elongation.
Subcellular Localization:
[CLELn]: Secreted. Nucleus.
Sequence:
MDMLRSACFYFLLIVFVILSWSLLCDSRHLGHMEKKLSVNLDLLNKDNEEITKLEAPSTNKTNTLLSQSHAVVNHGDNGQINGKKTKEIHRVKRASDKKVSSKRVSRTWKIPKYPKKQPKSDQEHPGFNLDYMQPTTHPPHHN
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MSKVFEREVGFINSEPSLAECFTSLPPLGETFQSSSIKNSSLSDSTLIPPPCEQGFSILNSGNTFQNERSPTSQDVDSAALGIKPLEYPWMREKKTHKGKQASLPGASSSGSSTEDNEDFQDNYAASPFDNSRRLRTTYTNTQLLELEKEFHYNRYLCRPRRIEIATLLDLTERQVKVWFQNRRMKHKRQSRFKQGKINESKGILSNGDNNNGFPRGLSETGLNPDPSKQLKFEDASNDHTLLREASSLPGIQNDDNFFISDETGYETGNSFECLNTLSLEDLDTISIDSFTAELPKLGVTDNDTTNSVADTFNFLIENICTTDFQQLQF
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Required to prevent genome instability induced by breakage-fusion-bridge (BFB) cycles. Can extend completely non-telomeric sequences using RNA template in vitro.
Miscellaneous:
MISCELLANEOUS: In the absence of telomerase, telomeres decline by approximately 500 bp per generation, a rate 10 times slower than seen in telomerase-deficient mice. This may be due to alternative telomere lengthening, a process which is activated in early embryonic development.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MPRKPRHRVPEILWRLFGNRARNLNDAIVDLIPNRNIQPEQCRCRGQGCLGCSSDKPAFLLRSDDPIHYRKLLHRCFVVLHEQTPPLLDFSPTSWWSQREIVERIIEMMQSGCDCQNVICARYDKYDQSSPILELLTSSSWEFLLKRVGHDVMVYLLQQTSIFLPLLGKKHQQVSGPPLCIKHKRTLSVHENKRKRDDNVQPPTKRQWLSSAVDDCPKDDSATITPIVGEDVDQHREKKTTKRSRIYLKRRRKQRKVNFKKVDCNAPCITPSTNGKVSTGNDEMNLHIGINGSLTDFVKQAKQVKRNKNFKFGLSETYSVIPPNHILKTLRPNCSDSKLLMNHIFGEVNVWSTTPSHGKGNCPSGSICLYHSLLKSLKNLIGKTKSSHLKMLLDKHCPVLLLQEDALKSGTTSQSSRRQKADKLPHGSSSSQTGKPKCPSVEERKLYCTNDQVVSFIWAICRYIVPESLLGTTHQMRVLRKNIAWFVSRRRNEKCTVNQFLHKVKPSDFPFFARKELCCMVNGHELQSESIRSTQQMLCTKWISWLFLEIVKKLVHFNFYATESQGGRLNIYYYRKRSWERLISKEISKALDGYVLVDDAEAESSRKKLSKFRFLPKANGVRMVLDFSSSSRSQSLRDTHAVLKDIQLKEPDVLGSSVFDHDDFYRNLCPYLIHLRSQSGELPPLYFVVADVFKAFDSVDQGKLLHVIQSFLKDEYILNRCRLVCCGKRSNWVNKILVSSDKNSNFSRFTSTVPYNALQSIVVDKGENHRVRKKDLMVWIGNMLKNNMLQLDKSFYVQIAGIPQGHRLSSLLCCFYYGHLERTLIYPFLEEASKDVSSKECSREEELIIPTSYKLLRFIDDYLFVSTSRDQASSFYHRLKHGFKDYNCFMNETKFCINFEDKEEHRCSSNRMFVGDNGVPFVRWTGLLINSRTFEVQVDYTRYLSGHISSTFSVAWQNKPVRNLRQKLCYFLVPKCHPILFDSNINSGEIVRLNIYQIFLLAAMKFHCYVYEVSRFWKLHPQTLFKFITISVRYMFRLINRRVRRINTGSSFRPVLKLYKEEVIWLGLDAYIQVLKKKNSRYRMLLIYLKSALSKHSLSQQLSSELRYATDRSNSSSLWKLNY
The following text describes a protein:
Function:
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors precursor protein. It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTQVLFYGCLFITFSPILAFFFMVIAKNSQLVILTIGGSFFWLVSILIAAIWWYIIPPMREHWWFIISFSVLFQEIFRYIFFRLYSYGFNDRPSLNQIKETQHQMALDSMRKRKQAQQQKQQPPTNEIESINNEIIDTTNNNTNNNNNNNNNINDDDNKEITEEEKEKRKIEKQKQREIEINARLETLSARPNHTLSSAAIGVGSGVAYGFIMFGSILWESTGPGTLFSPACPSVNLFMLSSIITLFMTLLHVVYNVLAFQGYRSKKYHLVAFVIITHFVTTYLTLLNLPTKTTSCVGSILPIGIITVFSVGFCIFSLLKSDSITKIH
The following text describes a protein:
Function:
Putative chitinase.
Subcellular Localization:
Secreted.
Sequence:
MGIKTLIWLSILVVGIYCEISDEDAPVHYCFVNPPPKTRLSPNLLQNITTCTHLVYGSIPIDRDTGYPQYSVSDVESGYDIDNIRTFMRLRKYHPNAKLLMGVVRTKPFEDAATSVKVANGLRSHVKSKRFDGLFVTFNGIHLEYRASTSFLETISKDKKMSLTFGVTGRRVFAFDALRRLQEINDLVEYIYLDMGELPSNEELARVTHINPLFYNGSIPFEETIQGTVEELSKEGILPSRIVVGLTAGGWKFEIKETQDPLKISHGQYAENNGKRVSYQDACRARGAVIYDWQTMNEITVYRQTWMSVNLPTIKAMGEKMKWILGQKFAGIGISHALFDDPRGDCGTDPLPAHRLVMELIRNTIPANPAKCTRLCYLDPEEVEETFPIDNLKSDYCSHIVVPYFALDLSDKMIEEDKAEDLVKKIDDWRSKIVEVAPRLILSVGSKQASTIWQFLLGNDFHRKELAEGLVKAINSTNADGLEISWTSQPMVSDFDKKNLKSFINDIVAADTAKMVEIVVATSQQSAYSDFYDYEHLNKTASLIVLHSHRLHSDSLPFTGHPSPLRATSSMTNQKMSWESLLSHWVEKRVLPSKLVLSLSASTLSMQSLADVRSSAATPFGQSAFVSMLRSKKGDIHSQQEICESLKSGTGVTHWVDGAEVPYLRRYDQMVAYENTRSAHIKAVWASMEGVGGLALHNMHQDDPSAVCDNRTAFPILNALSRAQVCQTCLKQHDFKKCEQHDFVVSCNFELKRSTPVFKTDIVPYERCTEVVVEQATLTLGGNVNFNDVQQEQVVKNLTSLRSKMVKCGMVLSLSCGDSEKYLNSILGDNMTFAIGNVMNIMEKYKFSGVQLDCEKVIRRGNHIYFNTFVKKLAQKFESGKASNGCNRTLSARFSHYTQKPSTYYSVSLLNRLSHIALRMTDKHSVDLPFFFNHTKPEFPSTEKFVNIWKNVGLKPDKLVLELSPFGWQTGKKVGEKKKMTQGVNCVTAGNRAVYEHDYETLTGMTKHENGTINMPMIEDFRYKIGYIQREQLGGIALNVNGDDYTGICGRGSFPILKSVYSSHKCR
The following text describes a protein:
Function:
Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Prefers hypoxanthine, has 66% activity with guanine while activity with adenine, xanthine, uracil, orotate, or cytosine is negligible.
Subcellular Localization:
Cytoplasm.
Sequence:
MLDKLKESLRNSPVIKKGEYDYFVNPVTDGIPLTEPELLEEIADEIVRRFNPDPASVDKIVCIEAMGIHHATVLSLKTRIPFVVVRKRRYGLPGEVAVHQMTGYSEGELYINGVDGDDRVMVIDDVVSTGGTLLAVLEALREMEVEVVDVVTVIDKGEGSRVVKERTGFTVRSLVKADVVDGRVTVEDIPDGG
The following text describes a protein:
Function:
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently (By similarity). Can inhibit cell proliferation and migration and can stimulate exocytosis.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Note=Shuttles between nucleoli and the nucleoplasm.
Sequence:
MDIEDEENMSSSSIDVKENRNLDNMPPKDSSTPGPGEGIPLSNGGGGSTSRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYMLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKSEPPFYVGSNGDDSFSSSGDVSLSASPVPASLTQPPLPIPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALATVFNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGKFSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYAQLELYLNNKEDQKKSIFQKSERGGFRLKDTVQFHLYISTSPCGDARIFSPHEPVLEGMAPDSHQLTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGALLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDTAIEVINATTGKDELGRPSRLCKHALYCRWMRVHGKVPPHLLRTKITKPTTYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSFTP
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAQLYATLKTSQGDIEVRLLPNHAPRTVKNFVELARGEREWTHPATGEKSMARLYDGTVFHRVLSGFMIQGGDPLGNGTGDPGYQFPDEFHPDLAFDKPYLMAMANAGPGTNGSQFFITVSPTTWLNRKHTIFGEVTDAASQKVVDTIAAARTNPRTERPLTDIVIESVVVETRNA
The following text describes a protein:
Function:
Plays an essential role in early embryonic development. Plays an important role in the regulation of centriole duplication and directional cell motility (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cell cortex.
Sequence:
MNRVQVDFKGLPAHILENSIAAESLQNTRSSDNVLTPLTFPKSKVALWDPSANGEVVSLHFSYYRNPRLFLVEKALRLAHRHARQTNKPRFFCFLLGTLAVDSDEEGVTITLDRFDPGREQTGCLGKAPTALLPGDILVPCVFEAQHAASSTVHSSEDLNISFKMLQHFCCSKELLELSKLLTLRAQLSCSENMDRLTFNLSWAAVTLACTLDAVPIRAVPIIPTALARNLSSPAGVTQNSKRGFLTMDQTRKLLLILESDPKAYTLPLVGIWLSGVTHIHNPLVWAWCLRYLHSSSLQDKVLSEGGTFLVVLYSLTHRDPEFYQCKPSTGQQQLSFQLLTSRDSLTLYKNVEPSEGRPLQFELSSENQNQETVLFEEVLSQSVLTGTTLGAASAAPQNKLSISDHDSGVEDEDLSPRPSPNPHPVSQQTKRVHPLVPELSMVLDGSFLDGSVVNTQGSTPLSHSQSNVHRRNSSPALQGLSVLRPLVQGSVTKPPPIRRPLTPILSQPKNKLHPNPSQQTPQHSVSRKSLPSMRRSREGSSASSVSSSSSSSSTKNASPNGSFHQQRQRLSQGFPNKPQLIYSGPPTSGHSSAKKSSSVPSQTPVPHPSQHRIFHSTPAVNPCNCCTNHPSVAPLYQNNTWQGTPGYPTAVHSPCVFHCSPETVPPGDHCLSPSRQSLGCRVSPTKSPVCYHSTPPHYSPSSGPCVPTIISNKGLVEQTPSCQAQCCQVKGSKEPCLDTPMGLLPADAYRMLIDQERQLKLLQLQIQKLLESQSKVPEVSSEQNAQQQRPNQVPASPPKRTSVSIAVGTGASLFWSTPQETSTHEASSLEWQTETEPKSGCQNDSTVTSRDRSESACHYSEEHCPGSPQHPTSPQHNTSSGFGVQMFQSPVLGESASMYYQSQSQSKDLSENREIDDPRFYHELLGQVQSRLQDSVIVEDKVEQDQQSLLKTQSLSPVVHQSRKPLTTSSIPQTQKTKQPSSPPNQDRVLSATLKQLQQFGVNIDLDSSQEKTTRATVESASTLACINPEAVIPRLALSEPVGASIWGPSGSVDLSLEANAIALKYLSDSQLSRLSLGSQSSSPHSDPSTILLRRPAVEKSNVALSILSPSNMSLATCKYMKKYGLIEGEISSEEEQEDPIQVDSALGCSVQHETSKTISLGQEREEQNTAVLKNITNKPVVNLHTSPIDSQEQILQDLRPKMQLLLRGGTNSEKENATKRNLIERRSSLTENQRTQEVVDPQGSVGNFLDLSRLRQLPKLF