lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of nrd1 with RNA polymerase II (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDSLLLLKKSIAEKKDVKLLASSEATSKVEKIEDAQYILFDENTSPILIDEPTKFIKLENDSHFSLRSVYFAWLLRDTSIAEYIQQCSELGIQNLTFLERTDLISWLEGSSDSEHIIGLEKPKPEGSTDAATSMDVDLHKKSEEVNWLFENTRTVSNHNSVLHGIKPIDFISLRKDVLDYIHANKATASAHADEQERPAKKRNRDPIILLSPSASSLLTMHNIKKFLEEGIFVPPAEAAHAAGGGRGPELIALSHKSSNSKFGTMRFIIVEGTEKFKPDYWDRVVCVFTTGQAWQFRDYKWSEPHQLFHHVKGFLVQYVGDPPHPATHDWNVEGIFVERLRRHTDREVVSQLWDKLERWMENRWPLWNGRR
The following text describes a protein:
Function:
Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MEMMESCQFSPSEFFYDSSCIPSPEGDFGDEFEPRMTSFGAHKTDLQGSDEEEHVRAPTGHHQAGHCLMWACKACKRKSTTMDRRKAATMRERRRLKKVNQAFETLKRCTTANPNQRLPKVEILRNAIRYIESLQELLREQVENYYTLPGQSCSEPTSPTSNCSDGMAECNSPVWSRRNSSFDSVYCPDMPNVYSTDKNSTLSSLDCLSSIVDRISSSDQLVLTLQDPASLSPVASTDSQPETPGAPNSRLIYHVL
The following text describes a protein:
Function:
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.
Subcellular Localization:
Cytoplasm.
Sequence:
MPVPVDDSTAVLEPTEGIERPTKPAVKSRKRFVGSSKAATSRPVVRRVANQVPDDILHDKELNAAIAALPGNYNFEIHKTIYHIRRDNVQSVALQMPEGLMMYGCAIADIIERFTGALPMMLADVTYGACCIDDYTAKEMGAEMIVHYGHSCLIPVSQTTLKTLYVFVEIGIDTPHLSLSVRRNFPSSRSAFQRLILGAGEAAPGGKVPIALESTDESAQATPDLSTNDLPTRLALVSTIQFVAATQALRADLETAMPPLEKGEIEQEEEGMVAKVKRGDIGVWRGKYEVTVPQAKPLSPGEVLGCTAPKLNDVDALIYVGDGRFHLESIMIANPTVPAFRYDPYSKKFTREVYDHTEMRGLRGEAVKAARKNLDDQGSGSWAVLLGTLGRQGSLAVLKSIQNSLPADSLPPLLLLLSELSPAKLALLPNSQISTFIQTSCPRLSIDWGYAFSRPLLSPYEASVAVGRVKGWGGLSLDNGKEGGKLEGEGDYPMDFYADNSLGDWTPRHNPPRPRPARVRPQAQGCAQD
The following text describes a protein:
Function:
In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.
Subcellular Localization:
Endosome, multivesicular body membrane; Peripheral membrane protein. Prevacuolar compartment membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Vesicle.
Sequence:
MDFIAVYNPAVYAKEADSEAWRQLLLYHSFKEDAEEPTPQNEKLSLIGMIQGIWQFAHNFSEPETRGSVRYVDTQLERRRVIAVEVEDGHFMAFGVEDGKRYGCEYYVRELLQSYHVFRLHCGSMSEFADRGELTDRLNEHVVGYWQALKLVPEAIYASTLASVCWHDGYKVSELELRDRAWESYIKNEILLDSESFLGLKDMCIYKLPRDGRRSAAEYGLLRSFAPEFLSLPELSNWVYHLDRLFETALSSHVLAGHVRLSIGGDEQEEEGELRHDSQPASDVGARMWRNVTMPISMTYDTMSEVGNLTGINTLMSGLNSLTSGFSSMTSRLVRRADRQNSDTASLSLHVDHGFLISPLALEALPESYRYRRFQLRFSTDEPQWYRLLFWYYKDYLCIFIFHENFDKIWDPDYLQAIDAKLYDAMLQLEGSVVTEDNKPGRFAYGVFNKTTKRIECSLPLLRFSDKRSDEKSRQPLKMVVAGIDETLQFLTAGTFATNMATSRTNDEHMGPSATNTLRMPEPTDAPSSSWTLDITKLNLFQGLNENLRLEKMADTDSGTFLDSLSSEKLLQLNVELCRLYTGIRRSEYNKAGIQEEQLLRLNNGILFYISTSPTEDVLILKNWFMDDKYTKAENKRSTSASLLHSLGGDVRRWWNARTNREQ
The following text describes a protein:
Function:
Has a role in LIPH-mediated synthesis of 2-acyl lysophosphatidic acid (LPA). LPA is a bioactive lipid mediator involved in different biological processes, and necessary to promote hair formation and growth.
Subcellular Localization:
Endoplasmic reticulum. Cell membrane; Single-pass type I membrane protein.
Sequence:
MDLAQPSQPVDELELSVLERQPEENTPLNGADKVFPSLDEEVPPAEANKESPWSSCNKNVVGRCKLWMIITSIFLGVITVIIIGLCLAAVTYVDEDENEILELSSNKTFFIMLKIPEECVAEEELPHLLTERLTDVYSTSPSLGRYFTSVEIVDFSGENATVTYDLQFGVPSDDENFMKYMMSEELVLGILLQDFRDQNIPGCESLGLDPTSLLLYE
The following text describes a protein:
Function:
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
Miscellaneous:
MISCELLANEOUS: The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.
Sequence:
MDRRIFGLENEYGVTCTFRGQRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATPECDNVTELVTHDKAGERILEGLLVDAERRLHEEGIAGDVYLFKNNTDSAGNSYGCHENYLVARHGEFSRLADILIPFLVTRQLLCGAGKVLQTPRGAVYCVSQRAEHIWEGVSSATTRSRPIINTRDEPHADAERYRRLHVIVGDSNMSETTMLLKVGATDLVLRMIEAGTVMRDLTLENPIRAIREVSHDITGRRKVRLASGREASALEVQREYYEKAVDFCERRGIRTGTVERVLELWGRTLDAIEAEDLDRIGTEIDWVMKYKLLERYRAKHNMTMSHPRVAQIDLAYHDIHRRRGLYYLLEKKGQAARVANDLKIFEGKSVPPQTTRARLRGDFIRRAQEQRRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDDRVEKLIAGM
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MAGKAAKATATNANNNGGGGYIRTVTLRGFDGIRVRVSAATMAAASATARARLDEAIRRTPRHAAVPDDVLINVPGVARPVLARVADYCDRHYGGGGGGEGGEFAAPEGYGFDDPLARFDDELMDGADVGTVVDLLRAAAFLRVERLADLASREVAACMRGRTVEGIRQVFGIANDYTDEEEQDVRKENSWAFDAYND
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MICSISIQTFPCRAVALIQKFNERPCDSDKLDCSLAQKTTMSLQWTAVAFFLYAEIVVNLILCIPFISAHRWRVVFRWRIWGWLSSYWNKAFFAMITVLVVLFIDAVREVQKYSAPQSTQDATVNPNLYDNVHMKLFRAQRNLYISGFSLFLWLTMCRVVTLLNKTAITLENSAELQAQVDAALKEAKQHQEKEQMFKKVISEGEKSMAATKEQLKLELEKLSSQLKAAEEDRRKSNAEVEAMKRQAKGLALEYDRLLREHHQLQNQRPEDKKDQ
The following text describes a protein:
Function:
Has antibacterial activity against several Gram-positive and Gram-negative bacteria. Is weakly active against yeasts. Acts by a nonpore mechanism.
Subcellular Localization:
Secreted.
Sequence:
MFLIYLFVQTAESSWLSKTAKKLENSAKKRISEGIAIAIQGGPRRRRFVAEQDAIHSRVSREVPTLSDSV
The following text describes a protein:
Function:
Has exodeoxyribonuclease activity with lambda-DNA and salmon testes dsDNA. No activity with circular plasmid DNA. The physiological role of this enzyme may be to degrade environmental DNA, and thus mobilize nitrogen for uptake.
Subcellular Localization:
Secreted.
Sequence:
ASVTFWTLDNVDRTLVFTGNPGSAAIETITVGPAENTTVEFPGSWVGNWYAYPTDAEDVPGMLGEVQFGGWNGLTYFDVSAIVNPTDHDNVKQMWPAESRKPMSGCEVFPCDNAYWLPDDIQTKVTHEVDLWTTLGAGSTGLTF
The following text describes a protein:
Function:
Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MIRNRKPITNNNSNNSNNNNNNGKIKRRERILNRQKEQIEQFYTDFIIFVVMFIHVVVCPFTKVEESFNLQGMHDIINIGNKGSDERGVSFEYDHLEFPGVIPRTFIGSLFISSLSYLPLNIFFGSSATEFISKLFDNQFSGTTKMVQLYFVRLMLGTISCISIMIFKRSISKRFGNQVAFWFTLITVSQFHLMFYISRPLPNIFALILVIIGYSFWLNDDGNGNGNGSIDWMIMVLTIAIFIFRSEILILAGPIVLSCLFLQKNLKFHRFLIIGIFTALISIIFTVFIDSYFWRRILYPELEVFQFNTIENKSSEWGTLPFHWYFSTALPKTLAFTLLFFFIGLISKYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKSTPITFLLPILLFIGIYSILPHKEIRFIFYSIPIINLISAIGATKLWNYGKSRKNQLFKLLISLFTIGILIGNSMISLFSLYASSLNYPGGHSMISLHKHLNLTDEMGLLLLLPPHTNADVDGDDENQGIIDCKVHIDNMAAISGVSRFGELNDFCVYSKKERDVNFNDFNYLIAPNTSTTQLGFKEVDSISAFDHIKLKKTFPFFEIVESPTLYIMEKINK
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA.
Miscellaneous:
MISCELLANEOUS: Present with 736 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSLFFKPVISPQWSFPVLLKIGVRSYAGGPRTKHKGNSPLASVPTGSSNKNRKQKAKGKKGNKKNDPDQAFNFGEYGGLKKDVEMNMDSTNKLIQKISNFDQLLILPPVRDAVKEIISKESLKLQDSRKKTSENIIPSPIQTVAIKRISKNLMDPKLQIHAIAAETGSGKTMAYLIPLIDYLKRQELETPELWETLRKNVLIRSIILVPTHELVDQVYETVSKTKTLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNLFSIRMITRPDKVLSKVGFVVLDEADTLLDRSWLEETHSAIKRIPNINHLIFCSATIPQEFNKTMQRLFPTVVPIMTPRLHKLPFALDFKVINSALSPFKGSKIKALAQTLYAISNDDTEPGFEKRCIIFVNEKKNVPEIVNLLNKKFGHNAIGLTGEDTFEERSEKIMPFLSPPRPLSEVVAQSTSPPTSLKKFEIPDSNIVIGKLKNTNSNGTAPSNKSLHVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGRTARMKQGGRVFMLTDSKTKSWAKALPKIIKKHQRLS
The following text describes a protein:
Function:
G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTPDWHSSLILTAYILIFLTGLPANLLALRAFMGRVRQPQPAPVHILLLNLTLADLLLLLLLPFRIVEAASNFRWYLPKIVCALTGFGFYSSIYCSTWLLAGISMERYLGVAFPVQYKLSRRPLYGVIAALVAWIMSFGHCTIVIIVQYLNSTEQVGTENQITCYENFTQEQLDVVLPVRLELCLVLFFVPMAVTIFCYWRFVWIMLTQPHVGAQRRRRAVGLAVVTLLNFLVCFGPYNMSHLVGFYLRQSPSWRVEAVVFSSLNASLDPLLFYFSSSVVRRAFGKGLLLIRNPASSMLGRGAKETVEGTKMDRGGSQAEGVQSSEFVTE
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MSTTSDNAGAAPRSAKLPEKSSFAQTCNLLSQYLKEKRTLAITPRIEPKDEFPTTRPPVVMNFFTNMENPDEKSASVAAADSIPPGAEPPSATQMTIFYDGKVLVFNDLPSERAEEIMAMAGKGIAPSSRSITTAVSDNGGEQPLTKVSSDLPIARRASLHRFFEKRKDRVAARGPYQVNLQASSKPSGESYRFKKENEQSSKQFDLNL
The following text describes a protein:
Function:
Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.
Subcellular Localization:
Secreted.
Sequence:
MRPIITTTIALFSTLIAAEGNRGYDVIPIRPRSIQKKTCTVLSLGNQIDDTPQILKAFSDCNHGGTVVFPKDQVYWIGTRMNPVIDDVTIDWQGTWTLSDNLTYWRENSYPVVFQNHAAGIVFTGDRIQISGKGGGGINGNGNAWYNVEKADTQPRRPMPFVFWNVSEVTVEQFTIKDSPLWAINIMNGTNMSFKDMLVNNTAVNAPYGTNWVQNTDGFDTMDARNIKLTNFYYQGGDDCIAIKPRSYNIYAQNVTCHGGNGIAIGSLGQYVEDSSVINVTVKDVNIISYNLDMHNSAYIKTWVGALVPQSGYESAGQAQGDGWGNVTSILFENFHIEGAAIGAAISQNSGNNGSFTGTSKFLVSDITFRNFSGYLTGAKGDRTASISCSNVYPCTDIAFEDFHVAYQLNGTEAPATGTCSMVAKGGVEGMVGSGCV
The following text describes a protein:
Function:
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (By similarity). Phosphorylates ceramide but not sphingosine (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (By similarity). Independently of its lipid kinase activity, acts as a component of the TIM22 complex (By similarity). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space. Note=Localizes in the mitochondrion intermembrane space, where it associates with the inner membrane. It is unclear whether the N-terminal hydrophobic region forms a transmembrane region or associates with the membrane without crossing it.
Sequence:
MARVVRIFKTLRNHWKKSTVGFCLLAYGSHWLYGKHCDNLLRRAACEEAQVFGNHQILPHSAIKKATVFLNPAACKGKARTLFEKNAAPVLHLAGIDITVVKTDYEGQAKKLLELMEKTDLIIVAGGDGTVQEVITGLLRRDDEASFSKIPIGFIPLGGTNTLSHTLYPERENKVEQITEATLSILKGETVPLDVLQIKGEQDQPVFAVQGIRWGSYRDASVKVSKYWYLGPLKARAAHLFSALKEWPQQHQASISYLGPAERPPEEPEQKPSRPPLYVRIYRRLALYWSPPKVEVPVEPTPEPWEEAQLSAVELSITTQNHQPDLLRTLDSMSIHIEPDTISKGKFIQLGAQKMTDPLLHPEDSQVLLASRCSLHLPQGTEGHFSIDSEEYEAMSVDVTLLPRKLHFLCHPTRKQELLQSPTATAQS
The following text describes a protein:
Function:
Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L. Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z. Also selectively represses protein production by associating with host eIF4E (By similarity). In cell-based minigenome assay, has an inhibitory effect on the ribonucleoprotein machinery (vRNP), which is responsible for the replication and transcription of the viral genome (By similarity).
Subcellular Localization:
Virion. Host cytoplasm, host perinuclear region. Host cell membrane; Lipid-anchor; Cytoplasmic side. Note=Mainly perinuclear. During budding, associates at the inner side of the plasma membrane of infected cells.
Domain:
Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins.
Sequence:
MGNSKSKSNPSSSSESQKGAPTVTEFRRTAIHSLYGRYNCKCCWFADKNLIKCSDHYLCLRCLNVMLKNSDLCNICWEQLPTCITVPEEPSAPPE
The following text describes a protein:
Function:
This protein catalyzes the committed step to the synthesis of the acidic phospholipids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNIPNWVTVSRLLALPLLFLWLPTPEAETRWWGVGIFLLAASTDWLDGYLARRLNQVTELGKFLDPLVDKLLVLAPLLILLTWQVVPPWAVGLILARELVIAGWRVNPQLASQTEIAGANLWGKVKTVTQITAIALLLAPLPEIYGQIGTVIFWIAVVLTLISGAIYLFPPGNNKVEAG
The following text describes a protein:
Function:
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MNLILISSKIIYKNNEEYFFKTDNRQTSHLKNILNVTLNQIIKVGVINKGKGEGKVIEESKSYYIIKLLTPIHLEEKSDDNVLPIDVVLCIPRPKVLNKLLQQLSSLGVKKIIIVFSDFSNKCYESSKILKNEEIKLALQLGLEQAMCTRFPEIYIHYSFSSFFMNIEKYTDEHTLKICAHTNVKKKNMESIEYSILNMEKGKILLMLGCERGFSELELYLIKKLNFHFFNLTERILKCETALLIIIGQLLLLTENISLRKSGTKMRRFSPHKKEIINNNTCENITHMKNNNNNDIQNVFDNDKIQYEMQLINQVKKLLTEETFSSEQLINFIQNTLHVQEKKRICTSNNNLSLPDEKLDNNDDVNIIDILLRGISTLNGNEENNFENVYLSLQLKKIKYKQRFYLSYSDIKNNVDDDGVYIYRTQRYVSKKKK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MTSANFDINFLLLAYFRCSVISCGKLHTCPLYREPTRITNIILVEKVVKVSKSLETIVRQEKMSALTPRPGDPSTSLQRLHHVEKKIVHTVELAGRVMEELAKTGGPRQEVVNVQCQEFMQAVKEIQTTLRDEIKSMCEYRPYENSDYPARINSEISVKKLECVIGQIEAMREAVAQYEAVKPM
The following text describes a protein:
Function:
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs); Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular Localization:
Cell projection. Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MPAYHSSLMDPDNKLVGNMAFLPIRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEIKNEADRTLIYIPLYISECLKKLQKCNSRSQGEKEMYTQGINNFPIPGEPSFPLNEDEVMRACLQQLRQETGLRLCEQVFNPQNDQPSTWWTCFVKRQFMNKSLSGPGQ
The following text describes a protein:
Function:
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Beta adaptin is a subunit of the plasma membrane adaptor.
Miscellaneous:
MISCELLANEOUS: Present with 1670 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.
Sequence:
MSDQKVFARYKANEIVTDLQHFGVKKFKSNITRRKNALRKIIANLVLGNYGEMSVLFSELLKFWQIEDDLEVKRICHEYIRVIGALKPQQAREALPFIMDDFKSRDEKLQIMALRTLVLVPVKELSDQAFDCIISLVNHKSPPEQVTRTAIYALLDLDEIDHERVLGLSSILHDIVKAQSSSPEVIVAALHTLYSIHEKNANMEPFRIPLELAFDMLELLPELNEWNKATVLEVLTTSVVPQHYLDTHEMIELALPYLQQVNTYVVLNSLKFIMYLLNYVDVIKETLAEKLSNSVIALLDKPPELQFLVLRNVILLLLSRESSLLRLDISYFFIEYNDPIYIKDTKLECLYLLANKETLPRILEELEQYATDIDIQMSRKSVRAIGNLAVKLDEDSVHDCVAVLLDLLEFGVDYVVQEIISVFRNILRKYPNNFKANVTELVKHTEVVQEPESKNAMIWIITQYSDVIPNYLELFRVFSSNMFSETLEVQFSILNSAIKFFIRSPTKETEELCMDLLKGCIDHENNPDLRDKTLMYWRLLSLTKTSRISNAITFESLKSVLDGELPLIEMNTKLDPTVLEELELNIGTIVSIYLKPVSHIFRLNKTKLLPQSPILNPNKDLLPVVGNSFPPTGANRDRQNSESQSSTKSRKTAMMDDYDKPAEKINQLKGKRKSSSNNPSKLSRKPSTLLRKLSMKRPFS
The following text describes a protein:
Function:
Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall.
Sequence:
MTLILPLWILLTLALVAIADEQTDCNPLNSTCPADPALGTEHTWWFNSTLDDALWNMTTGTPDYTSEGAEFSIKTENASTLLQSNFYIFFGVVEAHVKMAKGAGIISSVVLQSDDLDEIDWEWVGYNTSEVQSNFFGKGNTTTSDRGGFHPAADADTEFHNYTTYWDEKRLEWWIDGELMRTVNYSEPLTVYGKNYPQTPCRVKISVWPAGLPTQSIGNIEWAGGLVDWSDLPFTMTVQRVRVKDFQSAKEYTYSGHSGSYDSINIVSGNSTAKIEINKAPSKSLSEKWDELPTAAHIGVYCGAAVAGALAIAGFVLFCIRKRRQGRLERALAEGSQTTSATEMDTLKKQWRQSDWTASYRPLNQRP
The following text describes a protein:
Function:
Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
Sequence:
MSKATSACSQKKTSLLDPSPKKSSVIETTTKKTSGIESKLLPNELPSTGTTGTSGVKNGASSPKTSPAKTTTTTTTVVTQKVSNQPTAPISTLPPRKPTAQKSRELSPPKAKKSPSPSRTGSGDSGSRKESSASRKDSSKTEKLVKDLENVKLEKGDSRESATLPTPKQYPASDDEEDTKERKSLRFGTTTEWQSDNLEEFYREHEKFPNAEAVKKFGQMYSMTELIAETWLETRRQQTYQKYVEKGLQTDPSVIQFYCESLKIAEGLRLENPSIQTKSFFSLNGVNALEQKKEEEEKMQPVISVSSNKVFISPKKEQKCQLTIKNDGEVNVVYQISIMNAANYVMSPICAILLPKEELTLNITRKPGKLLEEEFFRIDYGVAPEGIIDARDSSDRAEFTNREIIEVVEIDEKEMKIVR
The following text describes a protein:
Function:
Binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MTMRHCWTAGPSSWWVLLLYVHVILARATSAPQTTATVLTGSSKDPCSSWSPAVPTKQYPALDVIWPEKEVPLNGTLTLSCTACSRFPYFSILYWLGNGSFIEHLPGRLKEGHTSREHRNTSTWLHRALVLEELSPTLRSTNFSCLFVDPGQVAQYHIILAQLWDGLKTAPSPSQETLSSHSPVSRSAGPGVA
The following text describes a protein:
Function:
May play a role in spermatogenesis.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MSYFVSPQSHLGLLPSGQGGAASSGSSLGLYSPAEPVVVAPGGLGPLSQKAEQVAPAAQAWGPTLAVPEARGCSGGVSWETPRRKEHNRYCPKLPPMRPLESLGWADPCSRSRAPYLGGPSRPRPLLLCGLSPGVLPISSEAGGKEAASQPDICILTLAMMIAGIPTVPVPGLREEDLIRAAQAFMMAHPEPEGAVEGVQWEQAHAHAHMASGQMPLVRSRRGSCL
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Sequence:
MLNRLLRPQASLRAASCISQKPISAALPRFQTRGVHNVPNLVHNAYFQKHGIPEFLSPEAYDFSWTQYQGLMVDKLNLLTQDTVDADLKPGDLLVKYSRRPEMASVFNYASMAHNNHFFFNCLSPTPTQIPETFANEISKSCSSVESLKLDFLATANAMFGPGFVWLAKNLEREGMMHIFCTYNAGSPYPAAHARRQPVDMATHTPDTALGNQYAGAMGAHSTNQKNIAPGAVDVQPILCVNTWEHVWMMDYGIAGKAEYLERWWDRINWDVVVDNYNAVRAKSSHRVAKDGRNLHHL