lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. May also be involved in maintenance of normal mitochondrial structure and organization.
Subcellular Localization:
Early endosome membrane; Peripheral membrane protein. Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle, autophagosome membrane. Mitochondrion. Cytoplasm, cytosol.
Sequence:
MEWLAPALERDLGIDQRQTAHSQRPNELVVLVPTRWVMALRNKRVTRCAKYESFSEGEICTLLQRSQMKLPSGWTRVCIQGLRKRKLGYRFARETGCHGEGLSQDSFMTLMQGVSQSNFRNLWHEAYMTHVQPYADSVEQTPVLALDAVRQALQKLFCSNFISTDRVSPSLSPAKEKEKDCPFLSTCSAPKQSTESLCPNVLPAECLLESEEVLYVVFPYTQYTVHDIVTYSPAKLANSNAKILFILYQLLIAMRECHASGLLCGELSLLDIAVDEQLCSRLKISLAHYEKFKEYRDAVPYALQNKVPMSVSTKDNHNNGVSGQLCRNCQDELKSLVLDWVNGQVSNFQYLMELNRLAGRREGDPNYHPVLPWVVDFTVPYGRFRDLKKSKFRLNKGDKQLDFTYEMTKEALAAVSGSGGSNYPPDLGGPVVPGGPGQSDHLHVPHHISDVLSDITYYVYKARQTPKSVLCSHVRSQWEPNEYPASMERIQSWTPDECIPEFYRDPSIFRSIHPDMPDLDVPPWCNSYEEFIAVHRQLLESREVSQQLHHWIDLTFGYKLSGKEAIKAKNVCLHLVDNHTHLTSYGVVQLFDHPHPPRLALYQYAPPEPPHFGRVNVTTWQIPPLETTMDGVDGLVPEATGCESSGWSVVGRDEELEQAIEALDLSGSSSSTSASVSIPVVGSAAGKTSGETIGLVVSPSHGSFPGEATGNVTNTLGSGIRTAMLHRAASVSKKPEASNLEDFKISLPDGFKPLQPLEELEKLNTFLVKGLHSEIEHTMDLGINKKDLRSVPKVPLSFTDLFQRDMQALGVLIAEIFYSSKLRGLRPETHLRDRFQAVLKLCSTNLRDVPLPLHHALDTLLQVHKHCLKTETIIMHPQGLPFLFKYDPICEGLPPPNPWQLLSPIVSPLPFPEYFPTLHKFIFSYHSKMESINNIQGRDIVFNLWQQLETLLKGDITTEGLEILLPFVLSLMSEESTAVYAAWYLFEPVSRVLGPRNASKYLIKPLVGVYENPRCLRGRFYLYTDCFVLQLIVRLGLQVFLSSLLPHVLQVMTGFESCNTAAGTEWEGMKVLRGAAGALDEEEEEYECDDRRSSNATSSGKVGGGSGGGSGGVGVVGDQGLVDYSSGISLNDQVFLNEGEDFQNGFYVNNSASGATTVGTKQQNQSTANKDQDQESLSVGKLSDKSSASEVSIGDRASLKSADSSQDLKQASDGEDGGELEDEEETVEDREITVQRVPSLEMTLSVCTEESEATVATLEGDVMNGIVQEDGEKNMEEEETEHDPLEDSEEKEHKILLDTVCKTVRWLSAKLGPTLTSRFIARNLLRLLTSCYIGLDKHQFMLSVNEENSLECVGSVYEKKPVVGDQTARPVLECLIYIAHLYGEPVLTYQYLPYIGYLVSPPSSCRLNTRKEAGLLGAVVLTQKIIVFLSDTTLMDMLMKINQEVLLPLLDLLTSTKMGFPSGVQTRSAVCLKTLSLMALICLRIGREMVQQHMAETLSRFFQVFSLLQFLQNQIGSAPRREVAECTYLDLRIPDGAELTIELGVLEELQAVFNPEMAYASYIPFYCLIGDSGIRKLVTNHELVWSLAQSYHERASPGSPESNPVGGQRASAVGLSPSMGRQMSRSPFPAPSSTSTPLGGDILPESGTFGSHLVGNRIQVTRDTEACGSPNLSSLETWTHGRPYGSNAPPMSLATTALSSAGPSFSHSSYSWVMGPTPEDSALKQDLPRSSRSLQGNWLAYWQYEIGLNQQDSHFHFHQIRLQSFIGHSGTAKCLAPLAGEDYFLSGSKDKTVRLWPLYNHGDGTREVEPRLTYTEHRKSIFYVGQLEALQEVVSCDGTVHLWDQFTGKNIRCNEPLDGKNPITAVTTMPAPHCSVVFASADSVLRFIDPRKPGLQHEFRLAYSNLSAGLIRCLAVSPGGRTIAAGFSTGFIVLLDARTGLVLRGWPGHEGDILQMKAAEGNLLVSSSSDHTLTVWKDVEHKPLHQYRTPSDPIHAFDLYGAEIVAGTVANKIGVYSILDSTASLAGSTKLSTENFRGTLTSLSVLPTKRLLLLGSDNGAIRLLA
The following text describes a protein:
Function:
Component of a regulatory phosphorelay system that controls B.abortus cell growth, division, and intracellular survival inside mammalian host cells. This signaling pathway is composed of CckA, ChpT, CtrA and CpdR. CpdR is a response regulator substrate of ChpT. Unphosphorylated CpdR controls steady-state levels of CtrA in the B.abortus cell, likely via CtrA destabilization and activation of its proteolysis.
Subcellular Localization:
Cytoplasm.
Sequence:
MKRILLAEDDNDMRRFLVKALEKAGYHVTHFDNGASAYERLQEEPFSLLLTDIVMPEMDGIELARRATEIDPDLKIMFITGFAAVALNPDSDAPRDAKVLSKPFHLRDLVNEIEKMLIAA
The following text describes a protein:
Function:
Controls cuticle development and morphogenesis, by promoting cutin and suberin monomers loading. Involved in the regulation of abscissic acid (ABA) biosynthesis in response to osmotic stress. Plays an important role in osmotic stress and drought resistance. Required to ensure a reduced permeability of aerial tissue, thus preventing transpiration. Regulates lateral root hair development; Required for infection by the pathogenic necrotrophic fungus Botrytis cinerea, probably by regulating structural traits of the cuticle.
Subcellular Localization:
Cell membrane; Lipid-anchor. Secreted, cell wall. Note=Polar localization with accumulation in epidermis outermost cell wall.
Sequence:
MGFSRSLNRTVGVFVFFILDIVDFLLCFTYKTLDFFFESEWKPCYCCPPPEAKPISAGGNRGGKMIVSERSGDYSKVVSLTRTKIYLDEISDTLYSRPSLLTKLTKLVKCFKKDVVKCCDESKKRSPSTKKTLLTVNSTVVEKLQRTPRWSDCHCTFCTSWLSSSNQSLFVNVQQPTDNKAQENVVFIHGFLSSSTFWTETLFPNFSDSAKSNYRFLAVDLLGYGKSPKPNDSLYTLKEHLEMIERSVISQFRLKTFHLVAHSLGCILALALAVKHPGAIKSLTLLAPPYYSVPKGVQGTQYVMRRLAPKEVWPPMAFGASVASWYEHISRTVSLVLCKNHHLLEFLTRLLTRNRMRTYLIEGFLCHTHNASWHTLHNIIFGSGSKVEAYLDHVRDNVDCEVAVFHGGRDELIPVECSYGVKRKVPRARIHVVPDKDHITIVVGRQKEFARELELIWRRSTTPQLHSIN
The following text describes a protein:
Function:
Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton.
Sequence:
MSELGVAVGQKIELADGSGRTAFVRYVGETAFAPGTWVGIELDEPSGKNDGSVQGERYFNCEMGYGMFVRPTTFNVIAQPPPPPPPSTFRRSVTTRPTSLNASTTRRPAPVDSGLAKRMSLNAPSPSPGPRPSRTSSTSITRSPTRSPTKQLATASSSGNPSRSGTPSTTTKPAGPTTRTRPSLSTSRHSMGPPPTPTTRTTRKPSVSSVGTRPSIGATRPVGGRASMSARSSTNRLSDPRESTGSVSSVGKSGFKRGSASPRSSDEELSASPVPASPVHQKTAALEKLTAPGAGNGGGGASPGATSPNLKATTITPRSSITNTATMNKEIEDLKAKLKVLEKKRMEDREKLNSLEKVKAERDKFERIIQTLQIKYQPQQQEIQDLKRQLKEAENRLYNVEELQAEHDTAMELATLDREMAEETAEVLKVELDALKQKNEELELEVEVLREENSEFTNGMSPEERASTGWLQMERNNERLREALIRLRDITQQQEEELKDQIKSMEEDLREFETIKEQHTTAKEKLAQTEAIVEDLREQLNNALGAEEIIESLTEQTMNQSEEIKELRAVIDDLESLKEINDELEINHVQNEKEMQEEIDLKDSIIAEQFRQANLQRESLEDMEYTLSRFRELVTSLQSDLEDMRASHAVTENESEQLNSRSRAMLDLNMKLQISASKAQVKTIDLELRRMEAQEAEQHLEIVKLFLPDTYQSDRDSVLALLRFKRLAFKANLLNGFIKERVNGQPHPGHEDDIFDGCDAIDKLTWVSAMCDRFVNAISHCSLEQFSRYEGALYELEPVERALNGWIDGLRRDDLKEKQCADELKRTIALMTHLGEVHISNDLESFADDVHMKALLMQSHLESAAISVNSLKAMVQRVIPSSGEDDELAQYFSKRAEAVVSQTRSAKVIAGKTVRALEDLKTRSLSLTPDTLEAFEQSETATRDLANMARQIGLDLHAFLHEEGRTEPYNYMEVQSCIQRSAQASSPTASSPESDLFNTYLSYLRNATSTISDLASLASDLAQTQEFDRTPAPWILRSAELKAAKTVAPDINDELRRLRDDIAEARRSIAVREEMLSTAQVKIETLESRMRDANAKAARIVDLEADLQAAKKEAAQLQEDMEKQDRELKALESDRDKWKKIASESRVVVADGSGVGVDNKASAERAVATAREMDALKKEIEALQAAVRYLREDSRRARLKEQGDYEWLAEPLVKKKPSVQEQRKQLVKKEGKAVLGELVKLVSSAKVFDLGSLPEKAEDRLKWRPAKTTPGWWVAKQMEDWEALKEWEGSVKGRVRELGGVPGSKKAEREEEAKRMVRRTAAAKLQIRLPGMEGKVGHGGGGGSGRRVQIVGSREWESLQGRLAVVV
The following text describes a protein:
Function:
Small polypeptide acting as a regulatory molecule which coordinates cellular responses required for differentiation, growth and development, probably by restricting polar cell proliferation in lateral organs and coordinating socket cell recruitment and differentiation at trichome sites.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MCLFMSNSSLPTKPNRKTRFGDRCLLMAKQQRTRLYILRRCVSMLLCWHDHSISD
The following text describes a protein:
Function:
Pectin methylesterase (PME) inhibitor that can target PMEs (e.g. PME2 and PME3) in a pH-dependent manner, mainly in slightly acidic conditions (pH 6.3 and 5.0) but not at pH 7.5; this processus relies on changes in the protonation of amino acids involved in intermolecular and intramolecular interactions. Regulates de-methylesterification of pectins in the apical meristem and affects primordia formation and phyllotactic patterning.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MAPTQNLFLVAIAFAVIFTASTVHGRHNGAEDIVHSSCEHASYPSLCVRTLSSYSGPTITNRRDLAQAAIKISLSHAQSAAKKLAVVRDSVGKKKQEKAALVDCVEMIGDSVDELSRTLGVLKHLRVSGGSAKEFRWQMSNAQTWASAALTDDDTCLDGFQGMDDGEIKTEVKQWMTKVARVTSNALYMVNQLDETRGKPHDVHL
The following text describes a protein:
Function:
Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTEGPRAADEVRVPLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPPRLGADEEQRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPYPSRPHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRVPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHSSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLKLATGLGTMNYPTILPSGVGSGKGSTSPGPKGKWAGGPPRTGGHSLLSLNSPDPYENIQHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRRDPTQPHPATDTPGPGSPRRRAQQRAAPGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAVPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPNGAWSSRRSSWSSLGRAPSLKRRSQCGERESLLSGEGKGSTDDEAEDGRATPGPRATPLRRAESLDPRPLRPATLPPTKCRDRNGQMVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNGFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGSDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSKALPVAQRRPYYADYSPTRRSIHSLCTSHYLDIFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMNAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKVPAAAVGRHCQGGHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQGPGSARRVDVDRPPSPQESPGARDAPNLLVARKVSVSRMLSLPNDSYMFRPVVPASVPHPRPLQEVEMETYGAGTPLGSVASVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDIPRDTLDPAEPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLXXXXXXXGLYSVDAQGFLDKPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPPAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEKRRGLYLTVPQCPLEKPGSPSATPAPGGGADDPV
The following text describes a protein:
Function:
DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.
Sequence:
MSDLFTKKPIPPLAHKIRPSSFEEVIGQSKATKQLANYRFPVSIILYGPPGTGKSTLAGILCRKWNLPFVEYNAVSTGVAEIKKLLERAEREGTILLFLDEIHRFSASQQDSLLKGVETGHLILIGATTENPAFRITRPLLSRCQILKIEPLSLEEQSSLLERGIQNIEYSINLNQDAKETLIRFSGGDGRKLLSNLEGLSFSFPENHTISKSDVEEYLESRVIEYDKSGESHYDVISAFIKSVRGSDPDAALYYLAVLLEGGEDPLFIMRRLIILASEDVGNASVNGLPLAVSGLHALDAIGMPEGRLILAHVTTFLASCPKSNASYKGIGAALAFVRKYGTGIKIPNRLRNAPTFLHKKEGASKDYIYPHDFGGFKEQNYFPDEFAENPPKFYFPTGNGAELKLKEYLDKIWEKTPWKKGN
The following text describes a protein:
Function:
Involved in meiotic DNA-break repair. Required for the recruitment of DCM1 to meiosis recombination hot spots.
Subcellular Localization:
Nucleus.
Sequence:
MHNQEEWLDKDKTLVNEEENTCINHSYTKKDTNNYRVGKSGIKDLKKPTNQKEIAIKNRELTKQLTLLRQENNHLQQACKILSENKIIENRKSIEKWRTICEMELSFILNSTLIKINRMGGYKDFLEKEMEAKKRRLEYQIDNGMEDQICEIKESDDFRQLSEVEKQEWESQMNEQLKELEKKKIAELEKLNKVLHDSEGKDFGMAELCTRLKLDYSLIFPQ
The following text describes a protein:
Function:
Catalyzes consecutive E-type condensation of two isopentenyl pyrophosphate (IPP) molecules with an allylic substrate such as geranylgeranyl diphosphate (GGPP), farnesyl diphosphate (FPP) or geranyl diphosphate (GPP) to yield the medium-chain product trans-C30-hexaprenyl pyrophosphate (HexPP). GGPP is the physiological substrate.
Sequence:
MSIIEFWLEAKATIDRLIEQFLNSNRDWDLVDISSYILKDGKRFRGTLNMFFTVALGGDIKDSYGGALAIEILHSASLALDDIVDLDATRRGDKAAWVVYGNRKVIFITNYLIPTALRIIQTSYGDDALNTSIELWKDTSVGALRDMYDNSDYIRTIELKTGSLFKLSTVLSAYASKHYNTKQQMLDVGKYLGIIYQVIDDFVDYKTKKVEEIDGSAKQLFKYYREGKLEEYVRSVYLEYKQKYDELISNIPFQSKYLSEIRSLPEFLANGLLKEANIDKI
The following text describes a protein:
Function:
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Sequence:
MIWTRARPVRPLTLNHLHIQGPIKYSDAQGIHDKLVRKFLDCKKEGKETPDPVLLTFQMQPVYTMGRRQGKEDALLETPNHRETKSEPSDEPIDVSKADIAHTLRGGETTFHGPGQIVAYPILDLLQFRKINDDGSDSALSPKCYISLLESSIISALAQYQIFTTRTENTGVWTMDGESKIAAVGVNIRRNITSHGICLNVNNNLSWFDHIVPCGLDEKKVTNVHEQGPPVKYEEVVHDYAYSLASYLDVNYKRVEKEAQA
The following text describes a protein:
Function:
May be involved in the energy metabolism of the mature sperm.
Subcellular Localization:
Cytoplasm.
Sequence:
RAKRTAPPSGRGLPPTLRYQASLPRPLRTVPCPGPLLGSQRVRLTSPRPRIHPHPVTPGVPRTQLTATERLPRAAHYPARPHRARLPLPRVQSAPHTVPQRAPAARRRPLQTAAARILDAFDGCSSPENAPCEPKRGGVAPVRGTPSLQPVLEKTQTSCACLRSPLRSSSNRHSNSPPPASSTRHRLHPLMCQVEFELARAALKQLKGPVSDPEKLLIYGLYKQATQGDCGVPAPPASDVKARAKWEAWSANKGVSKMDAMRSYAAKVEELKKKEVGGREREQRGVQDGRREELGGQSEELKKEVGGMEREQRGVQDGRHEGLRGQSEEVKEEEAG
The following text describes a protein:
Function:
Catalyzes the conversion of methylthioalkyl glucosinolates of any chain length into methylsulfinylalkyl glucosinolates.
Sequence:
MAIGDGEPVLQFKSVCVVGGGMAGLAVARELRREGHTVTVMEQSGDVGGQWLYDRRTDVEDPMGAVAPVRVPSSIYACLRLISPREVMGCSDFQFLPREGAGRDPRRYPGHRELHCYLRDFCHVFGIMETVRLNTRVLRVAPAAMSMSTTTRRWAVRSVRRLGGTEDDDGALEDEEVFDAVVVATGNYAQPMLPNDIQGMDEWRRRQLHSHSYRTPEPFHGEAVVVVGCGASGKDIALDLGRVAREAHLAASSEAEATTPAMSRMLANHGDVLRLHPRVRQLRADGQVEFADGSSVVADTVIYCTGYAYSFPFLDTGGAVTVSDGGYVVGPLFEHVFTPSLAPSLSFVGVPRKVLIPWFFEVQARWVAQVLSGRHALPSEEQMLRSVEEQLRAREAAGVPRKHTHNIASVEPRDMYEFGGKYCDFTPTEEWKKELILSSNASMDDDVETFRNRADGDSENVRKGRQGWLGGLVAQAQEETAVKTEF
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQITIVGSLNYDLVTISNRLPNAGETMFSQGFETHCGGKGANQALATARLSSKVPDVNVKMYGKVGKDNFGTQLKNNLKDSGVDVSAIHELDTKSGVAVIFVDQDSGENRIMVYAGANGEWTEADLTDDLFDTDMLIFQNEIPIDIVYKAIEKAGSKKPKVVYNPSPVDERGNIPAAVLNSIDFLVVNVTEATLISGVEINEEASKEEIWKQADQAADTLFKMGIKEAVVVTLGGNGVIYKTKTDSGHVPSNKVEKIVDTTGAGDTFLGGFSTSIIQGKTVSEAIAFGNKAGGIAVTRRGAAEGIPYDHEL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MADLRGIEAASEEVDSIHFSFYGDDEIKRSSVKKITKSERLDAKNLPVPGGLLDPAMGPINDTDTCKSCGQHSVRCPGHFGHIELAKPLFNPLLFTSLKNLLHVTCFHCHKFRLNKEQVDRYVNELELLVKGDVARAKNLEDSGKRASPSEEDEDITEATSCDKPSPEKDKKTWTSVQLKEVLSIFSKIMKKRQKKCAKCDMKSPTFSSPIFGWLVKDTSASAVRANAIADFKLKGDGGAHSSGETGVSGFDEERTSPQSKGSINEVRHLSDDTIKEFVASSGKKHLLPTEVESILKGLWKNEARFCMLLCDFQQDTLSVSEKRKGYEMFFLNSLLVAPNRFRPSTSSSLGIMEHPQNVLLSKVQEANLALQHNSASSNHMDVLRRWMDLQRSVNVLYDSSKGIVKSEKNAHGIRQLLEKKEGILRQKMMGKRVNYACRSVISPDPYLAVNEIGIPPVFATRLTYPEKVTPWNAKKLQEAVRNGADIHPGATHYRDNSNIYKLQAAPAKRRAIAKMLPASRGSISQPGKDPNCEFESKVVYRHLQDGDIVLVNRQPTLHKPSMMAHFVRVLPGEKTIRMHYANCSTYNADFDGDEMNVHFPQDEISRAEAMNIVDANKQYIGPRSGDAVRGLIQDHIVGAVLLTKQDTLLSREEYSQLVYGSCVPSNWGPRQPGIKVSAIKDDDALGFVLPAILKPKPLWTGKQVITTILNHLTKGRSPFTVEQKGKISEEHLTPKKFEKRKESESERKIAISELVLYIKNNELIKGMIDKAQFGQYGIVHTVHELYGADTAGILLSTFSRLFTLFLQFHGFTCGVDDLLLCQKADEARRSIISESDKYSEKAHGTFIKTGKDGEELQMEVEKVIRRDGESATVNMDREISNALSNITSDVNKNVFPYGLQKPFPGNCLTLMTATGAKGGDVNMYQISSLLGQQELEGKRVPRMVSGKTLPCFLPWDTSSRAGGFISDRFLTGLRPQEYYFHCMAGREGLCDTAVKTSRSGYLQRCLIKCLESLKVSYDHTVRDVDGSIVQFCYGEDGVDVLKTSFLNKFKELADNKKVVLDKIKGHKQNQLLSKPNGYITTLPKKLVAEAKEFLKLLKEKKSSDIKKGLMCDIKKKGLMKLLKVKYLYSLVDPGEAVGVVAAQSIGEPSTQMTLNTFHLAGRGEMNVTLGIPRLKEILMTASANISTPIMVCPLLEKWTRDDARRVAAKLRRVRVADIVEKIEVCTVPFYNTNGHVSTLYKLQMKLYPQKHYPPQSDLTVDECQTTLRTVFVDAMEHAIEKHLDLLHKINEIRAVKVNDAEGSLSDGGEESESRHGDGEETGMSDGDDENDNDDDLGTDAEKRKRQERDEMEYDDDTENEEGMDSESEEETKVKHQSEEDPAESGDDLQEADEEHKTSKSDMTSVDDMSYSAKKVKKSKDKHETAKLQERTHTEGKSDERKQDQMTYKRKKKLKRTVHVESKDLDFEIHYAFCDEPHILLAQIAQKTARSIFVRACKNIDKCEVEEKKEKGSSAVLKTSGVNFEVFWNLRKYISINKITTNDIHAMLKTYGVEAARATIIEEVNHVFGVYGIKVDPRHLSMIADFMTFDGGYRPMNRLGMGQFSTSPFGKMTFETATKFIVDAATHGESDSLECPSASICLGKPAKVGTGTFGLLQNLALEQPMAI
The following text describes a protein:
Function:
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins GlnB and GlnK, in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
Miscellaneous:
MISCELLANEOUS: The transferase reaction proceeds by an ordered bi-bi kinetic mechanism, with PII binding before UTP and pyrophosphate (PPi) released before PII-UMP. The uridylyl-removing reaction proceeds with rapid equilibrium binding of substrate and random release of products.
Domain:
Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
Sequence:
MNTLPEQYANTALPTLPGQPQNPCVWPRDELTVGGIKAHIDTFQRWLGDAFDNGISAEQLIEARTEFIDQLLQRLWIEAGFSQIADLALVAVGGYGRGELHPLSDVDLLILSRKKLPDDQAQKVGELLTLLWDVKLEVGHSVRTLEECMLEGLSDLTVATNLIESRLLIGDVALFLELQKHIFSEGFWPSDKFYAAKVEEQNQRHQRYHGTSYNLEPDIKSSPGGLRDIHTLQWVARRHFGATSLDEMVGFGFLTSAERAELNECLHILWRIRFALHLVVSRYDNRLLFDRQLSVAQRLNYSGEGNEPVERMMKDYFRVTRRVSELNQMLLQLFDEAILALPADEKPRPIDDEFQLRGTLIDLRDETLFMRQPEAILRMFYTMVHNSAITGIYSTTLRQLRHARRHLQQPLCNIPEARKLFLSILRHPGAVRRGLLPMHRHSVLGAYMPQWSHIVGQMQFDLFHAYTVDEHTIRVMLKLESFASEETRQRHPLCVDVWPRLPSTELIFIAALFHDIAKGRGGDHSILGAQDVVHFAELHGLNSRETQLVAWLVRQHLLMSVTAQRRDIQDPEVIKQFAEEVQTENRLRYLVCLTVADICATNETLWNSWKQSLLRELYFATEKQLRRGMQNTPDMRERVRHHQLQALALLRMDNIDEEALHQIWSRCRANYFVRHSPNQLAWHARHLLQHDLSKPLVLLSPQATRGGTEIFIWSPDRPYLFAAVCAELDRRNLSVHDAQIFTTRDGMAMDTFIVLEPDGNPLSADRHEVIRFGLEQVLTQSSWQPPQPRRQPAKLRHFTVETEVTFLPTHTDRKSFLELIALDQPGLLARVGKIFADLGISLHGARITTIGERVEDLFIIATADRRALNNELQQEVHQRLTEALNPNDKG
The following text describes a protein:
Function:
Expression of the ptox operon (ntnh-orfX1-orfX2-orfX3-pmp1) in B.thuringiensis kills Anopheles but not Aedes mosquito 3rd instar larvae. The ntnh-pmp1 construct is about half as toxic.
Miscellaneous:
MISCELLANEOUS: P.bifermentans strain Cbm (subsp. malaysia) is toxic to Anopheles mosquito 3rd instar larvae and less toxic to Aedes aegypti larvae. The presence of 4 plasmids, including this one, is required to kill mosquito larvae.
Domain:
Has 3 domains that are structurally very similar to those in PMP1; light chain (nLC, equivalent to the light chain), N-heavy chain (nHN) and C-heavy chain (nHC).
Sequence:
MDIIDNVDITLPENGEDIVIVGGRRYDYNGDLAKFKAFKVAKHIWVVPGRYYGEKLDIQDGEKINGGIYDKDFLSQNQEKQEFMDGVILLLKRINNTLEGKRLLSLITSAVPFPNEDDGIYKQNNFILSDKTFKAYTSNIIIFGPGANLVENKVIAFNSGDAENGLGTISEICFQPLLTYKFGDYFQDPALDLLKCLIKSLYYLYGIKVPEDFTLPYRLTNNPDKTEYSQVNMEDLLISGGDDLNAAGQRPYWLWNNYFIDAKDKFDKYKEIYENQMKLDPNLEINLSNHLEQKFNINISELWSLNISNFARTFNLKSPRSFYKALKYYYRKKYYKIHYNEIFGTNYNIYGFIDGQVNASLKETDLNIINKPQQIINLIDNNNILLIKSYIYDDELNKIDYNFYNNYEIPYNYGNSFKIPNITGILLPSVNYELIDKIPKIAEIKPYIKDSTPLPDSEKTPIPKELNVGIPLPIHYLDSQIYKGDEDKDFILSPDFLKVVSTKDKSLVYSFLPNIVSYFDGYDKTKISTDKKYYLWIREVLNNYSIDITRTENIIGIFGVDEIVPWMGRALNILNTENTFETELRKNGLKALLSKDLNVIFPKTKVDPIPTDNPPLTIEKIDEKLSDIYIKNKFFLIKNYYITIQQWWICCYSQFLNLSYMCREAIINQQNLIEKIILNQLSYLARETSINIETLYILSVTTEKTIEDLREISQKSMNNICNFFERASVSIFHTDIYNKFIDHMKYIVDDANTKIINYINSNSNITQEEKNYLINKYMLTEEDFNFFNFDKLINLFNSKIQLTIKNEKPEYNLLLSINQNESNENITDISGNNVKISYSNNINILDGRNEQAIYLDNDSQYVDFKSKNFENGVTNNFTISFWMRTLEKVDTNSTLLTSKLNENSAGWQLDLRRNGLVWSMKDHNKNEINIYLNDFLDISWHYIVVSVNRLTNILTVYIDGELSVNRNIEEIYNLYSDVGTIKLQASGSKVRIESFSILNRDIQRDEVSNRYINYIDNVNLRNIYGERLEYNKEYEVSNYVYPRNLLYKVNDIYLAIERGSNSSNRFKLILININEDKKFVQQKDIVIIKDVTQNKYLGISEDSNKIKLVDRNNALELILDNHLLNPNYTTFSTKQEEYLRLSNIDGIYNWVIKDVSRLNDIYSWTLI
The following text describes a protein:
Function:
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (By similarity). Constitutes a pore-forming and calcium-conducting subunit (By similarity). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MVMMKKLLSNRLFNMSKTASQSLMNCRTSSSSSLAMRTRVPKDIGEATIDPEPGDLTISQRFLNKFSMNGIDTTSKMSIGESLMEKLKEMDMNKDRIRLDGLSHPKEETLGLTVQDVKKLLRAAEIEVIKTKLMETGKIWIRYSDFLGVCSDSSLDPSQGALIAKMLDDSGNVIVMGNSVCLRPHQLTKSIEGLLPLSQIHNPNDPRRKELNELEAIKTVIDQKAHSLVRRELWAGLGYLIIQTAGFMRLTFWDLTWDVMEPICFYVSSVYFMAGYTFFLKTSREPSFQGFYQSRFEAKQRKLMQSEDFDVGRYDELKKLFNPKPSGAVPKILGSLQN