lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play a role in responding to changes in cAMP levels.
Sequence:
MDTIKETDSFSKYQIGEAVGKGAFGKVFKALNAETGDFCAIKQIEKTIISEKQLPSIIQEIKLLQTLQHPNIVKFIESYETSRYLYFALEFIEGGSLAKIAKRYGCFQEPLLSRYFSQVLKGLAYLHEKGVIHRDIKSDNILITKEGVIKLADFGSCTYSAIDRKLTVVGTPFWMAPEVIQMDMNARSTACDIWSLGCTLLEMLTGNPPYWDLGTMPAMFAMVNNPHPPIPNNISADLKHFLLACFVRDINKRPTASQLLEHPWIKQHIHEPSQSQPASSPEPSRIKSSGSGSKLSINTYAEGYDVESDDDTTNSNNGSDHDRIQQLESQKKEMTETIKRLKLHFLRAMKEKKVMKDMISQLVTERDEYMIKLGLTPPPLPPILANATLNSKSSLDSSNELLNKESSQGNLLGSGGSGSPYTNHTRSSSAPLTAPGKIISTHQIHSPSLSNSSASASTSGVSNNKERGSSILTNDFFHPPSDDDQHSPTNDLFLHEHFEKNLKVTASSSPSSLSKNSRLTTKFELESDNNTNNNNNNNNNNNNINITTTTTTTTTTPASNQNLGAYYQSSGNLHLYTNQNNLTNNNINNTNNNNNNNNNNNNNNNLGSNTNVDMYLRTSSEKTHLSITQPVSLSGALSYGDHLNPSVTIGGHNSLKQKGSGKTSIPVLQKEPSNKSLNSLNNNNVNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNSNSNNNTNNINSTNNINTNNINNVLGTSPSRKISNSDQFTPNRKSSQPIAPSFSLLNQSLDRNPNSNNNNNNNNNNSNNNNNNNNNNNNNLNSGSNSFNNNSPISSFTNNNNNNESGDEYDDDSDIIEDEQSSNSSLSFNNSNVPQVESVVVNVQPPRVGDECKVKCGDGWYDAVVDLVSGSTFVVTIKPFKIKREVSHSDVTLAPLQFPVTATKKKKFSLFNRK
The following text describes a protein:
Function:
Involved in riboflavin biosynthesis. Converts 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQIPEKYLSSVDNVEEETQILFALSKQKDADLGMLDSKQEQIALTIGNKPIKVKQSLQSLHQSRGSTGSVLWKTSVKVVPWLLQQSWFMNSLTPKTSILELGSGISGLAGILLSPFVGNYVASDKQLYLKKIRENLDQNNASDVEVHELDWKSTPYPKDWTFDFLDYVLFFDCIYNPHLNAHLVSCLASLAERYPGMQCLFAQELRDQETLVDFLERVRPYFEVDLIKMEEINKTSVASSTNLPPANMSLFIMKPYNHEEYMLKALNEAKKCEPTDSAFCVGAVIVQNGKIVSTGYSRERPGNTHAEECAIEKFMLKNPTDSLEGAIMYSTMEPCSKRLSKKVSCTDLIVKQKFSTVVLGSLEPDIFVKCEGVDLLKKAGIVVIEKLTFQDDCLREAVRGHPPKH
The following text describes a protein:
Function:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
Subcellular Localization:
Nucleus.
Sequence:
MCFMELSPATQVEKLPGWESLSSPDQATVRALVKKVPSAAKTGKGTGVPQDKQLQSTSRAGTKRKKDDAKRFGSGSKIEAQNKDLWTLKDDLKKHFTTAELHEMLEANGQDATGSELDLRDHCADGMCSSRLQFSGGMYRCHGYLSAWSKCSYSSYEPEHVKGKWKVPNETNTEYLSKWFKSQKIKKPVRLLPPSASSSQAANGQFQTSKVESLADLKVSITILPQESMIFAPQEEWKGKIKGVGGIIHAKIKDDTNCFVVSGKLDDHDAEVRKARMMKLPIVREDYLVDCFKRQKKLPIDLYKVEAIGWGKYNNTTLNMSDLSTGVNSYYILQIIQEDKASDCYVFRKLGRVGNEEIGGSKLEEMSKLGAISEFKRLFLKKTGNTWEAWEQKQNFQKQPGRFFPLDIVLAAMMEFKINMSEMPLGKLSKSNIQKGVKFLLHMQSRNFSDHISLAQMKMLESFEDIAIASRLVGFDDDSDDSLDEKYKKLNCVLFPFLMMVNIGSLRNISLPLMPLLILIGLLNWREYSHLKDKENLKSLLLIEKSLKTECFSGMVSGSWLTNFVGILSQGLRIAPPQVPATGYMFGKGVYFADLVSKSDQYCYTHKKSPVGLMLLSEVALGDVYELTKAECIETLPKGKHSTKGLGKKVPRESDFLKWKDDIIVPCGKPVSSKVKASELMYNEYVVYNTAQVKMQFLLKVRFHHKR
The following text describes a protein:
Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Domain:
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Sequence:
MARETFPFTSSMLRSLRLQQEWLEWEDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPAVHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPEMLKHCANFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPLLRDYLLLRVEGCIQ
The following text describes a protein:
Function:
Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase (By similarity). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present. Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination. Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70 (By similarity). In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin. Also involved in immunoglobulin V(D)J recombination (By similarity). May also act as an indirect regulator of proteasome (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome. Note=Nuclear localization may depend upon interaction with XRCC5/Ku80 and XRCC6/Ku70 heterodimer (By similarity). Localizes to DNA damage sites (By similarity).
Domain:
The KBM (Ku-binding motif) mediates interaction with XRCC5/Ku80 and XRCC6/Ku70 and recruitment to DNA damage sites; The XLM (XLF-like motif) mediates interaction with DNA damage response proteins TRIM28/KAP1, ATM and members of the MRN complex (MRE11, NBN and RAD50).
Sequence:
METLKSDNKKRVLPSWMTAPGNERKVVSVKTAKRKQTAAIRVGAATRAPAKETVYCMNEAEMVDVALGILIEGRKQEKPWEQPSLVAPDKLQLSPPCSESPHTSSPGSSSEEEDSRTDSPALGLSPARGPEASNSPCSRSPEEGKEEEDELKYVREIFFS
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MTVQACNSVSGTTIRSGMKSVATALLFLCVVRPAGASDGTAVAAVSDECGEIAYLQHLKSHDSRVAGDAAQSVATLTHEAHILTLAAEKHHGTINGAKYAFLAAIAADAKTEAVQTKLSQAAGPITSTAAERARRKGQLKALRHLNQATTAEYGETAVKAGTPTTIIGSADLGVTVKMQLNTAKADKCFLEATEPADIKNIVSEIANNDNYKGVDDSSFRPPQAELQMASRGNSPASMTNCERGRCCGDGAAMTSTNFLGLGTATKGQANTLTASTEPFKAGNQCTSPKKATSGDEAVINRKRTAHYLCNARQIQTQTTSSIKQTTVGQLRASEKANRLALAALGQTPKEGDNEQGKNAVKKLLGTDDSKTLDKFFSALETVDLQLSQDKGASKTSIKAAGESDNYGFALAYFSGQALKRTEEAAKSVTKATQAKEDDCTGKKRTECKGECELDGEICKPKKKEDGENKEKTGTTNTTGSNSFVIKAPILLALSLRA
The following text describes a protein:
Function:
Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate. Also displays malyl-CoA thioesterase activity. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate. Also has very weak citramalate synthase activity in vitro.
Subcellular Localization:
Mitochondrion.
Sequence:
MSVLKLRFAFLNHCVKLKSVSKTSTHFFTSRPLSSSCVNLGPLSPEVVPPPHKIQRPRRALLYVPGHDERKINKLQTLDVDCVALDCEDGVSLDKKEDARNTIHKLYEETASTFHGELCVRVNSPSSGFCESDIENIFSMSTLPPTVIVPKINSIQDITWMMNEKSRTILGRPTKRLFNVIFMTESSKGLINLQKIIEAGISACSPRFSCCHIAGIIFGSDDFCANLGIMRSKDASELIYARQKIVATCKAFGLQAIDMVYIDFKDNDGLEKQSLEGARMGFTGKQVIHPNQIPIVQKSFTPSDELLKWAEDLTEAFENSTEKSKLNFHTQGAFTFRGQMIDLPTVLQAKNIKLFSDFIKKT
The following text describes a protein:
Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Sequence:
MPEGPEIRRAADNLEAAIKGKPLTDVWFAFAQLKPYESQLTGQLVTRIETRGKALLTHFSNGLTLYSHNQLYGVWRVIDTGEIPQTTRILRVRLQTADKTILLYSASDIEMLTAEQLTTHPFLQRVGPDVLDARLTPEEVKARLLSPRFRNRQFSGLLLDQSFLAGLGNYLRVEILWQVGLTGQHKAKDLNEAQLNALSHALLDIPRLSYTTRGQADENKHHGALFRFKLFHRDGEACERCGGIIEKTTLSSRPFYWCPHCQK
The following text describes a protein:
Function:
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
Subcellular Localization:
Nucleus.
Sequence:
MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATTSASVSQQNPSKNREATVNGEDNRAHSVNNHAKPMEIDGEVDIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVSNTSGLLESGVLGAADAEVSFEGICSVRVLKGLAQCQRKLLGWIPSELVPHLGMAFSLSLPECPSSQHFLSQIVGSQPG
The following text describes a protein:
Function:
Probable inositol 5-phosphatase which regulates synaptic vesicle recycling in neurons by regulating clathrin-mediated endocytosis.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Synapse. Note=Localizes to puncta at neuromuscular junctions in the nerve cord.
Domain:
The Pro-rich domain is dispensable for endocytosis during the synaptic vesicle recycling, locomotion and for endogenous and evoked excitatory postsynaptic currents (EPSC) at neuromuscular junctions. May play a role together with the SAC domain in targeting unc-26 to synapses; The SAC domain, but not is catalytic activity, is required for targeting unc-26 to synapses, for locomotion and for normal endogenous and evoked excitatory postsynaptic currents (EPSC) at neuromuscular junctions.
Sequence:
MSVRGIRIWRRNDARFQPSILVEKNGLDGSLLFQGGAIATLDSDSTDVERRSYQKIVDAYGILGVLAITKDEAVLVAVTGVLSVGQLYGADILKITNVEFISLRTFGSVENVDSRIIDLQRLLSSQMFYFSSLQSYDLTRSAQHRDSHDCSDARFFWNRSLHFSFQRYGIDTDNWLLKCMAGSVLVRVVYVGANTGRVALISRLSCERVGTRFNVRGANYLGNVANFVETEQLLLFDEKECSLLQIRGSIPLFWEQPGVNVGSHKVKLRAFETSLPAYHRHLSQLQHRYGEFAIVNLLGRKEGERVLGDAFKTQHKSSHFAPLVDFIDFDYHAQMKISKEAIVQLKKKMSPHMTKHGFFYSMGKEIVKRQTGVIRTNCLDCLDRTNAVQTAIGLQMSHDQVAFLNLNAGKVNVEQRVEEILRDLWQKNGDQCSTIYAGTGALDGKSKLKDASRSLARTIQNNLMDGAKQESFDLFLTGAAYDPRLFDRACNILPPSLIQESYYYHEYADAVSQLVERSPEIAEPQSIKIFVGTWNVNGGKNIHNVAFRNESSLSHWIFANSMTRLVSVEDEQLADIVAIGVEELVDLNASNMVKASTTNQRMWCESIRKTLSEKAPFVLIGSEQLVGVCLFLFARPRVSPYLKDFAVASVKTGMGGATGNKGSVAFRIVVFSTSICFICSHFAAGQNEIRDRNEDFATTLKKIRFPLGREIDSHDVIFWLGDFNYRINLSGDEVKNAVRNGDYAKLVENDQLTQQKALGQTFVGFNEGQLTFAPTYKYDTFSDDYDTSEKCRAPAWTDRILWKDQRKKGKTQLLSYDRSELKTSDHRPVGAVFKVETFKVGGRKCVELIEDVVESMGPPDGTIIVSIAGKPRFPPQMFPPIHEKLKELGAQVQLSKFDDGDLWIVLNSGEMALAALSMDGLKIGGTDQINVKLKSPDWAYALKPHLSDFDLESFEVTAEEEALLGGTDGAVFEFADEDEDAISVSSLTLTGSAPDRPRPPSARSEAISVAKLEWPTEQPNVLSTSMPTRASSASLANSSWYEHVPPLAPPQSNNNKSPPQACLFNPFTQSAPSPAPPPSTIPLPPTRGASVGPGPPAVPVRKAPPPPPRPVIPPRPKNM
The following text describes a protein:
Function:
Plays a role in transcription regulation.
Miscellaneous:
MISCELLANEOUS: Encoded in the 5'-untranslated region (5'-UTR) of ZNF689.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MALRSIKSIAGSCLCSRQRRCGSSAAIFPEGIFRCLSPKFGQEFPE
The following text describes a protein:
Function:
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
Sequence:
MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHNLAQNKGIRPFPSEETAESDDDVYRSLEELADEHDLGEDVYDCVPCEDEGDDIYEDIIKVEVQQPMIRYMQKMAMTEDDKRGCCLLEIQETEAKYYRTLEDIEKNYMAPLRLVLSPADMAAVFINLEDLIKVHHGFLRAIDVSMMAGGGTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSTDRPEREQLKEALEAMQDLAMYINEVKRDKETLKKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRRGYSYELKEVIELLFHKMTDDPMNHKDVKKSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFAMAMSNIRPDKATANHHSFQMHTFEKTTSCTACRMFLRGTFYQGYLCTKCGVGAHKECLEVTPPCKISSPADLDASGAGPGPKMVAVQNYHGIPAPPGKPVLTFQTGDVIELLRGDPESQWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPMSRPPSREMDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDSWVHITEAKKFESLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLGLASQGSSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVKIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGVQ
The following text describes a protein:
Function:
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Subcellular Localization:
Nucleus.
Sequence:
MDYNAPPAADVDAFAAVLKGDIGGAAGSSAAAAYGMPRSGNGTSQPLPPQSPPATAVSGNTGSKPVPVAPTAATPGQQPTALQWSQLTPQQQQEIQRRTMQQRMHQQQQQQQQKQQQQQMEPGAPSTVAGNRKGNIREGISFTALMPLLQPHLPPEQGQQLSALYLQFKRNEITREDFIRGARVIAGDQVLVQTIRQMHMKQQQQQQLQQQQQQQALLRSQHQQQHQQLAQTPSTQPSLHPPPQPQGQAQSQPQVQVLAQPQTHAPAQSQGQGQPQGQGQAQSLSLSLSQTPTQGQTVQPQAQAQEEQISQTTSSNSSVPPPSPQELSKQPQEQTGTPIQTISSQIKQPVDQNLEAPESNGAQQSAAPGLPRAVSPQPIQVPPNADVQSLPQSQAFHPVPQVPSSLAQVQGSTVKQGDQQQESAGIGLPTNLKTPSPINLQTVKQEVDKLNLGRQQQMAPNFSSPPQRPSAPGLHQMPVVPAAVQIPQPFTPKAPPQQPPPGQATGHLQMQQTPAVAQGLAAGTVPQPHAQPQPQPAPQPTPPEKPLTKYAKQKLRKEQKKREEEERARKAAEEERLRKQNQSNTLPNVHQGLVPQHPTLPATHLPSASVDLNKQAYGHHPGSLSQQVTSQVDKQQGGPLAQVGPVISGQSGTAVKQELSDLQSDSLQKRQAMQLPKGSVLGQTPQKSGDSSLLSAANASHMQVQGSNAEAGQVLSPQGSAPGSFSNLVQPGGVGSLPNSGVMLSQGTVGVANLHTNKQVGGQRGIGSVSTAVPAAPAYNATSLHPTASLGVGASLPIGAAPGQNAPAPSASVPGAAPTPSGPVKTPSKKANVGQKKPAENSPAQQPSSKKQKVSTAGEPDQSIDQLNDVTAVSGVNLKEEEEQLLVGPKEESRTTEAMRKIVQEEEERLFLDRSALRLKLGAIAGKCNIKSVSEDVERCISMAVEERLRSMLYKLSKLSKQRCDVEKDRHKICITSDVRRQLLLMKRRAKELQDKKLAEESERLRRLNEKKDKGSLPDTEREELRAKAQKAQQEEEDRLKANAANVAARVAVGADDMLLKWQMMAEQGRQKRQGGDIGSAEENAASRAGNSDGTAGRSSEKKAENGDAGTGASGTNETDSQGATSLTATGRPPGPGPGATRMMSANGRRGMNPSGRGQRTISLKDVIAYLETEPQMSKSDILYRLYERERKPSDGDRTTVGNRK
The following text describes a protein:
Function:
Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The AWS and SET domains are necessary for transcription repression.
Sequence:
MSGNNSPINAQLFPDARDVTKDALQTFVELPECTYMKGLGSSQQAEVMACDCKPGPTACDEDSGCINRLTSIECVRCCKGCQNKRFQGKKYASVDVISTEKKGFGLRATKDIAAGEFVYEYVGEVIDEPTFKERTAIYTTQGVKHFYFMMLQKGEFIDATAKGGLGRFCNHSCAPNGHVEKWVVGKRLRMGIFASRHIQRGEEVTFDYNVDRYGAEAQACYCGEKNCVGFLGGKTQTESASKVSGTLTAALGLTSRDINAILRGKKSAEDLRPRDLTVQDVSKVMASLMMNQEAWQVNLMLQRIALCTDTSVQAAVMKMHGYQIFAQILTATWGDNPLGLDDSDRVNVTLMLLRVLQKWPRITKNKISSSQIENVVKSLTSNDNSDIATIAQELLSEWANLKMAFRIPRRKIDPDGDEHSVSRGTSEEVTKESSKSEEPNDVEVVKVNKKADNNGNGVTDSPSTRSESPFTFIPTPYSNKTAPKGPKKAVKQPASPMVPPRSLPKGWQFANDPQGKVYYYNLELNIQQWDFPKASRASSPSTPKGPKGPKGPRGNRRDERRDNSETREPLSLQSQRESDLQRIIEQARLQEVKNNSEPAPSASAKPVNAQAHRLTKLLAKVVPNQVSKYDVDRERAKKCSKDIVQILVDKELKRPEPMTEISDEKAKKIKEFVKGYMGKVVKRLEEKEGGAKDFGRGRQGNRRDSERQSDRRGRQGQSDRDHSDNHGRKRKGEENQPYEAGPMYDDESAETSTETVKKPKVDMEIDLE
The following text describes a protein:
Function:
Probably acts as an activating receptor.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MWLLPALLLLCLSGCLSLKGPGSVTGTAGDSLTVWCQYESMYKGYNKYWCRGQYDTSCESIVETKGEEKVERNGRVSIRDHPEALAFTVTMQNLNEDDAGSYWCKIQTVWVLDSWSRDPSDLVRVYVSPAITTPRRTTHPATPPIFLVVNPGRNLSTGEVLTQNSGFRLSSPHFLLVVLLKLPLLLSMLGAVFWVNRPQWAPPGR
The following text describes a protein:
Function:
May play a role in plant defense. Probably has no oxalate oxidase activity even if the active site is conserved.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MAKLFVVLVAALLALRAAPSTLAGDPGMLQDLCVADYNSVEGPLRVNGYPCKQAENVTADDFFYAGLASAADVYGGGNPMGSVVTAADAERLPGLNTLGVSMSRVDYAPWGGTNPPHAHPRATEILFVAEGTLEVGFVTTAGRHITRAVPKGGVFVFPRSMMHYERSVGEAPAVAISAFDSQLPGTQRLGEAMFGAAPAVPTDVLARALRIDGGVVESIRSKFQPN
The following text describes a protein:
Function:
Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane. Negative regulator of neurite outgrowth that inhibits axon longitudinal growth. Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides (By similarity). Inhibits axon outgrowth by binding to RTN4R. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane raft.
Domain:
The C-terminal cytoplasmic region found only in isoform L-MAG is required for normal myelination in the central nervous system (CNS), but is apparently not required for normal myelination in the peripheral nervous system (PNS); The extracellular domain is required to protect against axon degeneration. The first three Ig-like domains mediate interaction with RTN4R and RTN4RL2, but are not sufficient to inhibit neurite outgrowth (By similarity). The two C-terminal extracellular Ig-like C2-type domains are required for inhibition of axon longitudinal growth. Besides, the two C-terminal extracellular Ig-like C2-type domains are required for protection against apoptosis after nerve injury.
Sequence:
MIFLATLPLFWIMISASRGGHWGAWMPSTISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSTLSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPTVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQAAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGMVLREAVAKSLYLDLEEVTPGEDGVYACLAENAYGQDNRTVELSVMYAPWKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEKQILATVIYESQLQLELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNETEREFVYSERSGLLLTSILTIRGQAQAPPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESSSFSGGDNPHVLYSPEFRISGAPDKYESEKQRLGSERRLLGLRGESPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK
The following text describes a protein:
Function:
Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.
Subcellular Localization:
Secreted.
Sequence:
GIFSKLGRKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC
The following text describes a protein:
Function:
Putative FAD-dependent oxidoreductase.
Sequence:
MGASSSSNALMDKTVVVIGGSYGGNAAAIHLKGKCKLIVIDAKEAMFLSVSSPRAVVEPEFTNKILVPLTDVHGESFRRGKVVQIDPPEKTVSLEDGSTISYDYLVIATGSSNPFPGKITNDTSIQECHALYKEASEKVKAAQRITVIGGGASGVELAGEIATDFPQKDVTLIHSRDTLLEPAVRPKLRTMVEEQLLDLKVNLVKGEKVLDLSDIPTDLSGGFREVKTDKGTVVPSDLVFICIGMSVNKTVYANSLASSMDERGALRVNSYLQVEGFEEIFAVGDCSTADQQKMANKARLHGESVASNIPLHADGKAMKPYKTPGVLYAVSVGRNRGGIQIGSHIIMGSWFVKRVKGKDMFTTRLWSDNRLTVPAS
The following text describes a protein:
Function:
May be involved in a mitotic signaling network. Binds sumoylated proteins and may stabilize SUMO chains.
Miscellaneous:
MISCELLANEOUS: Present with 504 molecules/cell in log phase SD medium.
Subcellular Localization:
Bud neck. Cytoplasm, cell cortex.
Sequence:
METYETSIGTQSYPPTLFPPPLGTGGFTTSGYIHALVDSTSNSNSNSNTNSNTNSNTNSNSDTKIPIVQISDDSHITHDSFKPYMEYHDASHLRNRNISKADQVESTEVMEQFTQWSNYKMRSRSPTINAKPIRHTSQRRTDFTSKNELSKFSKNHNFIFHKGFLKRQHSIRREDRQAKVRSRFRSKKELTSVLNYIELEQMDIANVLASQPVNLHAIRNLTSRDPAVTPIPFLRSQMYATSSRPPYLRNRSISRKLPKSQPGSLPTTMPATATKTIKQNSTTPTTRSVYNKNVGRSNTSPSVLYHPKRRGKLNTKSHARKEQLLLELWREYLMLVITQRTQLRLTLLCSPGSASNESSVCSSNASDLDMSLLSTPSSLFQMAGETKSNPIIIPDSQDDSILSSDPF
The following text describes a protein:
Function:
Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane.
Sequence:
MCHLICRYHQCVFISVHSWKQVVGPVWIAVIYVNQVAYAVSLVAEGSKMDETSECFSLSKLNVRHLVAIILFALATNVQYKTFAYLASLRRNKAGHVVTTNYKPPNAGMFQQLNLSSPHYFAEIVIYFAVLVAMGTNCLTWMTVTYCVACHMTYLAYVTHQYYLDTFSNVYPKHRNIIIPFLF
The following text describes a protein:
Function:
May modulate osteogenic differentiation, at least in part, through the bone morphogenetic protein (BMP) signaling pathway, increasing RUNX2 activation and leading to osteoblast commitment and maturation.
Subcellular Localization:
Nucleus.
Sequence:
MVRRRQRLPEVDMGLVSFEDVAVDFTWQEWQELDAAQRTLYRDVMLENYRSLVWLGHCLAKPELISKLEEGFEPWGVAEATEQCLPGVRKWSAPVEKGQQSQEKYLRQVKIIKKNTPDEDKVEVENTYNVDSNCISNMTLKNEVCSRVFFQELVNPLLDVPLPTEAGERQSTEVPHDLNRTQEVLSYPKHFTHHSKDQYSQCCFQYFGPDEAFHTKAILTPEMFYVQETSRTCNNYDKSFDEVTIPAQYMTQLRKQTLGWNICHKIFPNKTELSNHDAMHTGENDDKCDYEKPIINKSLYLTKHQEAHAGIEPQAHKENIKFFCLDAELQTVDPELHGEKQVYECKVSGKTFRHQPEHISQQRPHACERACQAKEHGEAGCDEPALTQHQRLCTEEKACEGKACSKAFHHKSLLPQYQSARADEQQSDCKELMKIYFYVSSPTQHHGPPPPEKPFRCNDCLKTFSHKSQLERHQRMHTGEKPHECKECRKAFCHKSHLIRHQGIHAPEKPYECNECKKSFYLRSQLTLHERTHTGEKPFECKECRKAFSRNSHLTQHQKIHTGEKPHKCKECGNAFARKSHLIQHQKTHTGERPYECKECRKAFSRKSQLMQHETTHTGERAYECKECRKTFYLKAYLTRHQVIHQSEKPFECKKCGKAFSRKSYLTRHQKIHKGQTLSG
The following text describes a protein:
Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases.
Subcellular Localization:
Endoplasmic reticulum membrane. Microsome membrane.
Sequence:
MRTVSPTRDDPIALYPLQGLEKCFAHSKRLTNAIIIIIIPSNPWQPEAGGQLDARIPRFLTPSSNGLQHLPAGILSFVSKLRDKYGPVYTVYLGPRPVVVLCGLDAVKEALVDKAEEFSGRGKISIIDKIFQGYGVAFSNGQRWKTLRRFSLATLRDFGMGKRSIEERIQEEAQCLVEEIHKTEGELVDPTFFFNSVTSNIICSIVFGNRFDYRDKMFLTLLSIFNETFTLMSSPWGQVLFELFSGIMKYLPGVHRRVHSNLEYVNNFITQRVESNKKSLDPNSPRDFIDCFLIRMDKEKETLGSEFHMRNLVLTTQSLFFAGTETSSTTLRYSFLLMLKYPQVAEKVQEEIDQVIGQDRPPGLEDRTRMPYTDAVIHEIQRFSDLLPLGVPHIVTQDTHFRGYFLPKGTDVYPLLSSVLHDPRHFKRPDSFDPGHFLDARGNFKKSEAFLPFSTGKRICLGESIARMELFLFFTTVLQNFSLASPVAPEDIDLTPRESGIGKVAPPYQLRFLPR
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across the thylakoid membrane. Involved in delta pH-dependent protein transport required for chloroplast development, especially thylakoid membrane formation. TATC and TATB mediate precursor recognition, whereas TATA facilitates translocation.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Membrane; Single-pass membrane protein.
Sequence:
MFGIGMPELIVILVIALIVIGPQKLPDIARSLGKGLAEFKRASDDFQRNLAEEVRTLDEKEKAEKGEAAAEPVKRDLAAEVKAYEDQAASGVHQGEPAPVAGSPESEKKSA
The following text describes a protein:
Function:
Guanine-nucleotide-releasing protein that acts on members of the sec4/ypt1/rab subfamily.
Sequence:
MSNLRIVCQHCPSVVFNNKRPDVVKRPTMSAMLHSETQEDLETDDFFLLKDPFAFDNVSVSKPLANNYKLLACADCEKGPLGYYDSKNNEYLLLCSLEKN