lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Peptide hormone that functions as endogenous ligand for the G-protein-coupled apelin receptor (APLNR/APJ), that plays a role in cadiovascular homeostasis. Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR. Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs. On the other hand, APLNR activation induces beta-arrestin recruitment to the membrane leading to desensitization and internalization of the receptor. Apelin blunts cardiac hypertrophic induction from APLNR on response to pathological stimuli, but also induces myocardial hypertrophy under normal conditions (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates. Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (By similarity).
Subcellular Localization:
Secreted. Secreted, extracellular space. Note=Abundantly secreted in the colostrum. Lower level in milk. Decreases rapidly within several days after parturition in milk, but is still detectable even in commercial milk.
Sequence:
MNLRRCVQALLLLWLCLSAVCGGPLLQTSDGKEMEEGTIRYLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF
The following text describes a protein:
Function:
Adapter protein that targets and loads the Tle3 toxin onto the H2 type VI secretion system (H2-T6SS) machinery through an interaction with the TTR domain of VgrG2b. Seems specific for Tle3.
Subcellular Localization:
Cytoplasm. Note=Is not co-secreted with Tle3.
Sequence:
MSADAYHPPTTSPRLETLDVLSIGMSLDVFRQGQVWKALQEQNAAQAEALHVGSILPMDPKKYPTSADDKDMAYEKRQADALELGLKNFLEKWPIPTVTVVRGWDPSTPNLRFTPEETRESLSVKVNDLRVPAGLHWHRIANLQDGIICNDTPEGVLEALFSLFERNPDLPAVLVYANEGISMAGALSSRDVTLKSLGAVSGPRIPGTLTDAMVALIVGRPERVDWLRQFAPYTKVNENRIDPEFRGWGWRKPPVEFRPTPFIPQPWTERALEQWDALPVLARLHRPVSVPLTHPDTGERLKREALTAQLAAAWKTASAGLRPAPARLFYDGGLNATPLAELTPALGAAQSSLDLLDSRESYDLTQRLGDTGAASPFVGITLATMASYLNGDSSMVMPLRRKDQATLIGISSPTPGKKPVHDPFGVDLLPQTASGDGPPPSADPVAPASRLTTRLPPGEDYALEEFLSSLKPSTDWQDDL
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Sequence:
MSIVFVFAFRPNFSILVTPNAHLQKDFGLDILDLEEIVTTLEEEFGFEIPNNEANKTNSIKLVVDHIVSHPQANIALD
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MAQDLSEKELLRMEVEQLKKEVKNPRDPISKTGKEIKDYVEAQSGTDPLLKGIPEDKNPFKEKGTCVIS
The following text describes a protein:
Function:
A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton/electron.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLDIVELSRLQFALTAMYHFLFVPLTLGMAFLLAIMETVYVLSGKQIYKDMTKFWGKLFGINFALGVATGLTMEFQFGTNWSYYSHYVGDIFGAPLAIEGLMAFFLESTFVGLFFFGWDRLGKVQHMCVTWLVALGSNLSALWILVANGWMQNPIASDFNFETMRMEMVSFSELVLNPVAQVKFVHTVASGYVTGAMFILGISAWYMLKGRDFAFAKRSFAIAASFGMAAVLSVIVLGDESGYEMGDVQKTKLAAIEAEWETQPAPAAFTLFGIPDQEEETNKFAIQIPYALGIIATRSVDTPVIGLKELMVQHEERIRNGMKAYSLLEQLRSGSTDQAVRDQFNSMKKDLGYGLLLKRYTPNVADATEAQIQQATKDSIPRVAPLYFAFRIMVACGFLLLAIIALSFWSVIRNRIGEKKWLLRAALYGIPLPWIAVEAGWFVAEYGRQPWAIGEVLPTAVANSSLTAGDLIFSMVLICGLYTLFLVAELFLMFKFARLGPSSLKTGRYHFEQSSTTTQPAR
The following text describes a protein:
Function:
Transcription factor which may be involved in the signal transduction pathway downstream of the COP1 gene. Controls floral competency as a specific activator of FLC expression. Is responsive of the nuclear import of SHOOT MERISTEMLESS (STM).
Subcellular Localization:
Nucleus.
Domain:
The SR/KY and BELL domains are responsive for the interaction between the TALE/BELL proteins and the TALE/KNOX proteins.
Sequence:
MDNNNNNNTFSSLDNVMTNQNPLLMDFIPSREDSTSFSTMLPWNTIRSDPLQMGGFDIFNSMLTNKYLSSSPRSIDVQDNRNVEFMAPPPHPPPLHPLDHLRHYDDSSNNMWGFEANSEFQAFSGVVGPSEPMMSTFGEEDFPFLISNKRNNELSLSLASDVSDECSEISLCAATRLASEQASCSSKDISNNVVTQGFSQLIFGSKYLHSVQEILSHFAAYSLDYSSRGTESGAASSAFTSRFENITEFLDGDSNNSEAGFGSTFQRRALEAKKTHLLDLLQMVDDRYSHCVDEIHTVISAFHAATELDPQLHTRFALQTVSFLYKNLRERICKKIISMGSVLERGKDKTQETSMFHQHCLLQQLKRKNHQIWRPQRGLPEKSVSVLRNWMFQNFLHPYPKDSEKHLLAIRSGLTRSQVSNWFINARVRLWKPMIEEMYAEMNKRKLNNSHIQPNGPTLRMPKSVMMSQAMHK
The following text describes a protein:
Function:
Required for endoplasmic reticulum organization and proper vesicular traffic during vitellogenesis. Required for oocyte and bristle growth.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MATRGGPMVAGTDGNDFEFRQRVAGTYQISLLNKSRLKYCIFFHALLFFVMLAKLTSDILDRLDIFVLEIEELEVPSPLWWEYVWAGSLLTSFLGLSAARGNKVREMQKYMIAILVFAILPLLYCFAYYFSDVWEFATMDKSVELDETDIFIWRGYPYGVFWYAFCFVGFQVHGFTLYFAYNLVKVWKARTATRKFQ
The following text describes a protein:
Function:
Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation. Essential for RNA-dependent helicase UPF1 localization to chromatoid body, for UPF1-UPF2 and UPF1-DDX4 interactions which are required for mRNA degradation, using the extended 3' UTR-triggered nonsense-mediated mRNA decay (NMD) pathway. Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through interaction with arginine N-methyltransferase PRMT5 and symmetrically arginine dimethylated SNRPB (small nuclear ribonucleoprotein-associated protein).
Subcellular Localization:
Cytoplasm.
Sequence:
MCSTPGLPAPGTALALRVSFVDVQAEVIPVQLWGLVGERREQYVRLSREIQEAAAARGPWALGGAAASPGELCLVRVGLLWHRCRVVSRQAQESRVFLLDEGRTVTAGAGSLAPGRGEFFQLPSEALGCVLAGLVPAGGAGSGEPQHWPPSAVDFLSQLQGKEVHGRVLDVLCPQRLVLLDVPGLCQQMQELGLARQVPDSLFHLLLKRYLKAAAAGVGPGAPALPQGLPKAQQPGLDYFYPQLQLGVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQIYRASTGTRDENSTSATWEEREESPDKPGSPCASYGLDGHWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCAMYGLWDAGRGWSRSQVGDLKALILGHAVNAKIEFYCSFEHVYYVTLYGEDGINLNCVFGVQSCCLADRFLQSQGIEEEEEEEEPETALQSSSPAEEVDEEMSLPALRPVRLKMNAFYDAQVEFVKNPSEFWIRLRKHNGTFSKLMRKMCSFYSSASKLDGVVLKPEPDDLCCVKWKENGYFRAMVTRLDEKSVDVFLIDRGNSENVDWYDVRKLLPQFRKLPILALRCTLADIWPLGKSWSQEAISFFEKTVLHKELVIHVLDKQDKQYVIEILDESRTGEENISKVIAQAGYAKYQEFETKENIPLTARSPGRVSNHFTSENNKIPSSSKVEVEQKAKRENKATSVAEALSDPTVVANVSAGLVVQEKEKRVSVYSSLIQNFLEMKPASSGTGELQVGSTVEVKVSYVENPGYFWCQLTQNKKELKSLMCDIQDYCKNTATPYQGTTPTCLAKRTINGQWSRALISGGQSSEHVTVVFVDYGDKDMVSVKNIYAISEEFLKVKAQAFRCSLYNLIQPTGHSPFVWDEEAVQAFSEFVDNAEEDNLELKCTIFALASVHDKELFTIVDLLTPFQSVCHFLVEKSLARPVELQNPLESSVQLHSYYYSTHDVKIGSEESVYITHVDDPWTFYCQLGRNANVLEQLSCNITRLSKILLNLKTSPLIPGTLCLAKYTDGNWYRGIIIEKEPNKVFFVDFGNIHMITNDDLLPIPSETCDVLLLPMQAVKCSLSDIPDHVPKEVTTWFQETILDKSLKALVVAKDPDGRLILELYDDSIQINASINKKLGLLAYKDGERKKKENDALLSTTETLEVKKENMMMSPTEYLSKSVEKKLHSMEILGESYKPKISSACKELKLLQSSTKTNLVTQYQYSVGNKNNQVSPLTTEKKEESFAEPPLKATKLEASLSERKIGDSYNTDLPLRFSEFPQKTIISGFKTTVYVSHINDLSDFYVQLTEDEAEINRLSERLNNFRTRPEYYAGPPLQGGDVICAIFPEDNLWYRAVVREQLPDDLLSVHFIDYGNVSVVHTNKIGKLDLINALLPGLCIHCSLRGPWVPEIFNSKEMMHYFSLRTGESQVRCEFVKFQDRWEVILADEHGIIAEDMISGYAFSKTSQIGLSTQITKDACSMSVKRTDIDTSVFLNWYNPKMKMIRAYATVIDGPEYFWCQFADTEKLQYLEVEVQTAGEKVTDCRSCIPCPHIGDPCIVRYRDDGHYYRALITNICEDYLVSVRLVDFGNIEDCVDPKALWNIPSELLVVPMQAFPCCLSGFDISEGVCPQEGNDYFYEIVTEDVLEITILEIKKDVCGIPLAIVDLKSKGESINEKMKKYSKIGNSNSDPPDENNCLGIKGALGSPSPDVGLKRASSKAGQEKTLYVESQTDELSERTENDLNIETKPSKFYDPETDDIFEAFENPRKDNIGPELPEDKAECHFVDRAKFDDKYLVTGFSTLLPRASETKEILELNSLEVPLSPDDESKEFLELESLELQHSLVGDEEKEELGLVPPMVPLPQGCDTEAVLQPFTVQLPLNCEAEKQPELELPTAQLCLDDKINPLSLRLSQKAQESMCPEDTRKSSCVECFDDQHRLSLHPHGKNCDPKLQIEMNVYQEEFTAYKNRDAVSSLTSLFSGEESRDGRKHGNALPDHVPAQPENIYTLKGFTVGSKCVVWSSVRNTWSKCEILEIAEEGTRVLNLSNGLEEMVNPENVWNGIPKSDKSPSEATFQTLGKDLDFVSSDDTTIKEKASGGDTDLTVDP
The following text describes a protein:
Function:
Transcription factor that plays a positive role in salt stress tolerance. Interacts with TIFY11A/JAZ9 and binds to the promoter of some potassium ion transporter genes to regulate potassium homeostasis during salt stress.
Subcellular Localization:
Nucleus.
Sequence:
MVPRDRVNAAAAGGGGEGRLVQSGIVNKKCDKKAPKRIHKSEREKLKRDKQNDLFNELGNLLEPDRQNNGKACVLGETTRILKDLLSQVESLRKENSSLKNESHYVALERNELHDDNSMLRTEILELQNELRTRMEGNPVWSHVNTRPALRVPYPTTGVFPVQHLPHLPVTTTAAFPQQLPVIIEQHYAATPRELQLFPESATSEDSEPSQEHGISDHVTRPQPRYPTPTATLPVNLFPVFPGRQDQQCSSGTSGTNEEDRIGRS
The following text describes a protein:
Function:
Inositol phosphate kinase with a broad substrate specificity.
Sequence:
MANLIICLSKKGGEGWGGGEHGGTKRKIKKKYCEAPQILHTMLKVPDHQVAGHHARDGKLGPLIDDSGRFYKPLQGDERGSKEVAFYTSFSSNARIPDHIRRFFPIFYGTQLLEASDGSGLYPHLVLQDVVSGCHNPCIIDVKIGSRTWYLQASEDYIQRSLKKDRETTTLSLGFRISGLQIYDSKESGFWRPEKKLVLGFTADDVRVVLRKFLKAWFEDQTIFHFFSCSILIMYDKEAILKGMSSGAEIKLIDFAHVVEGEGVIDHNFLGGLCSLIKMISEILTSPDENPNITCLQDYEKNHSYLENGTTE
The following text describes a protein:
Function:
Converts monoacylglycerides (MAG) to free fatty acids and glycerol. Has a preference for palmitoyl-MAG. Does not play a significant role in ethyl ester biosynthesis. Also possesses ester hydrolase and low but persistent TAG lipase activity.
Sequence:
MRLKELLPNFLIVHQEVPEDPIAFKSTDKRENENKEITIPELIDTKVPELADGATDTLYGLLVNGHLQTAYGSFRHFDNIYKVQYKRMIIKYPHGGEGTVDFAVNGRSTKRRKVEKEYVPTSQPVFNGNLKRRYSYYSPDDPKLNSDDAKPMLIILHGLTGGSRESYVRAIVHEITTKYDFEACVFNARGCCYSAITTPLLYNGGWTNDIRYCVNDLRKRFPNRKFYMMGFSLGASIMTNYLGEESDRTKIECAISVSNPFDLYNSAYFINSTPMGSRFYSPALGHNLLRMVRNHLSTLEENPDFKDVIEKHLKKIRTVRQFDNLLTGPMFGYKNAEEYYKNASSYKRIPGIRTPFIALHAQDDPIVGGDLPIDQIKSNPYTLLLETSTGGHVGWFKDRSGRRWYAEPLCRFLKIFHDEITVKGLKPDLENVQLPDPNCEPIATTFRAN
The following text describes a protein:
Function:
Serine/threonine protein kinase required for cell-type-specific transcription and signal transduction in yeast. It is thought that it is phosphorylated by the ste11 protein kinase and that it can phosphorylate the FUS3 and or KSS1 kinases.
Miscellaneous:
MISCELLANEOUS: Present with 672 molecules/cell in log phase SD medium.
Sequence:
MFQRKTLQRRNLKGLNLNLHPDVGNNGQLQEKTETHQGQSRIEGHVMSNINAIQNNSNLFLRRGIKKKLTLDAFGDDQAISKPNTVVIQQPQNEPVLVLSSLSQSPCVSSSSSLSTPCIIDAYSNNFGLSPSSTNSTPSTIQGLSNIATPVENEHSISLPPLEESLSPAAADLKDTLSGTSNGNYIQLQDLVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKPHENIITFYGAYYNQHINNEIIILMEYSDCGSLDKILSVYKRFVQRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTFVGTSTYMSPERIQGNVYSIKGDVWSLGLMIIELVTGEFPLGGHNDTPDGILDLLQRIVNEPSPRLPKDRIYSKEMTDFVNRCCIKNERERSSIHELLHHDLIMKYVSPSKDDKFRHWCRKIKSKIKEDKRIKREALDRAKLEKKQSERSTH
The following text describes a protein:
Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient; Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEPLFWPLETISFQRFTPESLAAIEKKIAEKKEKQAKLKQETTDQEVEEDKVTPQLDLKTCKKLPSLYGDVPAELIGEPLEDLDPYYSDHRTFMVINKRRTIFRFTATPALCILGPFNPIRKAHFFLSLSFTLFVGFITCTVILNCASMAMNNYPLDFNGTEHIFTAIYTGEILIKVLARGLVWNEFTFLRDPWNVLDFLVLVVTYIIICTKSGNISALRTFRVLRTLKAISVIPGLKVIVNSLIESVKKLTDVLILTVFCLSIFALIGLQLFMGNLKNKCVLTNATYNDTLCKDAKIYNSSETGKYYYYICARMNGTSDILLCGYGGNSTGECPENYTCLKLGKNPDFGYTSFDHFGWAFLSLFRLMTQDSWERLYRQTIRSSGKSYILFFIAVIFLCSFYLFNLILAVVTMAYEEQNRATLAETQAKEKLLQDAKKVLEKEKMLSTGESNKASHIGFEMSVAGLENSEEKETRGEKPVSRQSLIVGNQSNEESMFQSQPNHCHKKLRQILLSYELSVDSINDPYRRQRLMSAATVITDNMKAQNSKMRFASVWKRLGQKYLIWNCCPFWRAVKGKVQLIALDPVVDLIIMICIIVNTIFMALEHPGMTSTEKRLICISDKVFTMVFAAEMVLKIIALDPYYYFQQKWNIFDSIVVMIGLISFHANLSFFRLLRIFKLAKMWPALNTLMKIILNSVGALGNLTLVLIITVFIFAVVGKQVLGKYYATEFNKISTTANLRWHMKDFYHSFLVIFRILCGEWIETMWECMEVAGQERCLPIFLLVLVIGNLVVLNLFIALLLSSFSTDSSLGQEEAVKQSKCEIAIARIHKGLQSVKERILDKCGKKREQSNNTTTKKKTSVKTSFKDLERNNYAMTDVGKDMDNSCFDVGCYNNEESSSVERKYEGSLNYHGGHIPLAVAEAYTDEGDDDEQSACTEGEYRKWGFDVGSYSEASTVDPVTLIELYSQPKKIHLPKDCCTESCVKYFPCCNVDITKFPGSTWWKFRKTCYKIVKHSWFENFIIFVIVLSSAALAFEDIHLKDRKTVKKLLEYADMVFTYIFIMEMLLKWVAYGLHSYFTNAWCWLDFIIVCVSIIYIYINLLCCREIGALKSLRTLRALRPLRALSRFEGIKVVVNALLGAIPSILNVLLVCVVFWLLFNIVGVKLLGQKFWKCVLKTGDNREVQNINDCRNYGGKWTNSYVNFDHVGMGYLALLQVATFKGWMDIMYAAVDARQVDEQPQFEACSAMYFYFVIFIIFGSFFMLNLFIGVVISNFNQQRKKISGKDLFLTEEQKKYYNALKKLGSKKPQKPIPRPLNAFQGFFFDIVSHKAFDISVVTLICLNMVVMMAESDNGEVRDVLKKINYFFVTVFTGECIIKIIALRHYFFTTGWNIFDLVVVVLSLVSIALAEVFSKFFSPTLLRIIRLARIGRILRLVKRAKGIRTLLFALLMSLPSLFNIGLLLFLVMFIYAIVGMTNFACLGWEGGIDNLFNFQTFDSSILCLFQITTSAGWDSLLSPVLKESETCAPNVPQNNSSCRNKVVGITFFVSYVIISFLIVVNMYIAVILENFSVATEESADPLSEDDFDMFYETWGNFDPQATQFIEYSALSDFADALAEPLRIPKPNTIQLISMDLPIVSGDKIHCLDILLAFTKRVLGEAGNFEGLELHMEEKFMAANPSKVSYKPITTTLKRKQEEVSALVIQRAFRRHLLQRSLEHKPFLHCRRRFNSAVYAEEMREKDGLIASMRGENYGRKLDKSQTTSSISLPLFYDGIAGTDTNKVDT
The following text describes a protein:
Function:
Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus. May have a role in the recruitment of stored chloroplast mRNAs for active protein synthesis (By similarity). Bind single strand DNA (ssDNA) and RNA in vitro. Exhibits RNA chaperone activity. Negatively regulates resistance responses to abiotic stresses during seed germination (e.g. salt, dehydration, and low temperature) and seedling growth (e.g. salt).
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MATFLTNVVSIKPTIFSFQSESFTPLHTRVNVFSSKPFPSLAGTFSRSSRTRFIPYAVTETEEKPAALDPSSEAARRVYIGNIPRTVTNEQLTKLVEEHGAVEKVQVMYDKYSGRSRRFGFATMKSVEDANAVVEKLNGNTVEGREIKVNITEKPIASSPDLSVLQSEDSAFVDSPYKVYVGNLAKTVTKEMLENLFSEKGKVVSAKVSRVPGTSKSTGFGFVTFSSEEDVEAAIVALNNSLLEGQKIRVNKA
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MTKEYTAIYSPEAKSAPKNKKKAAVRAIRDQDNVEISAGDVVLLKDDPDVEGKEFALIQGLKHGDQGLEAKCVLMKLFNDAEALTPKHVIPNTNKNRYSKGQELVMMNSIVDVLVEELHLPVNCYSFAEFEALSREDKKGDNVYFCRYVFDNDANKTSVEFDWQDITKDMCGFIDILYELITDKPRKRRAAVKASRQRSRHARDEDESDFELEEEEEEEEEDDIEDIDEDDEYDSPVEQVKKARTPKSAKKNTKKAPATTPRKRALEDLDLPQPDHNTTPMTTPKKKRKTENGHGLATPKRMFYKQALSDATLPYKTADLSPSKLSPHQSARAKLHVAAVPDTLPCRETEFSNVYLGIESAIRSGSGTCIFVSGTPGSGKTATVREVVSQLQIRVEDNEIPDFLFVELNGMKLTNPHTTYELLWEQLSGERLAYNNAIKLLEHRFQQKSNDTPLVVVLDELDQLVTLNQSVMYNFFNWPTLPHSKLIVVAIANTMDLPERTLSNKISSRLGLTRIQFPGYTHEQLKLIIESRLGDIAESSGTVVRPDAIEFASRKIASVSGDARRALDLCRRAVEIAELDSEEVQIKHIQQAANEATSTPIYNYLQGLPLAFKIFLCALLARKRRNGLPSDSLGDIIEEIERMIKSSENAGFLSHILLQGGKRVRMAGFMNAVTELVEAGIIIQQSIKGERSAQVRLTIGVEEITSALKNDDDVKGML
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MLKVTFSIISCYLNAFVAVFSNSILIFLIITKTPRSMGNYRFLMLIFSIFGIIFAFIDGTNQPMLHFYNGAYVIFSRNVLGLPRQISFWYIALNCACYGMIMLLLVYHFLYRFLAVCHPTRLKIFSYPYFSILVLIFILISAGWLILAIHVAGENPVVDEHIRDTMLINFDLTRFDYTYASSLFYRKNPVTKEEYASIPDFLFLLNLGLIIGTGFSIVIYCWFKLRKELLNSAGQIQNLSQRTLDMQRQLFRSLVAQTLFPVFLMFIPAGILLCFPIFKTNMGPIEIIILPLITTQPFMDALVPMYFIKIYRMAILKFFCRSKYDTRVHGVLSLAMDNSGTRGNSTKNVSLKI
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAVSSGTSGMLATCLFMLLFATMQIYKSQLTSSQPMAIVGGFLGSVLFILILTAISNFETHFFGRNFQTKLIPEVVIALVIAMAASGMVHRVCITTCLIFSIVALYYVSRISIKVHGSGAGTATAIPVTKGKKGK
The following text describes a protein:
Function:
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Sequence:
MVTEIRSLKQLEEIFSAKKNVIVDFWAAWCGPCKLTSPEFQKAADEFSDAQFVKVNVDDHTDIAAAYNITSLPTIVVFENGVEKKRAIGFMPKTKIIDLFNN
The following text describes a protein:
Function:
Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (By similarity). May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion (By similarity). Also involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part (By similarity). Functions in cytokinesis by regulating contractile ring formation and vesicle trafficking during cleavage furrow ingression. May also have a role in the intital steps of central spindle formation. Can also bind phosphatidylinositol-3-phosphate and phosphatidylinositol-5-phosphate in vitro.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cleavage furrow. Note=Phosphatidylinositol 4-phosphate-binding and oligomerization participate in the recruitment onto Golgi membranes. In dividing cells associates with vesicles in polar regions of the cells during metaphase and anaphase, and localizes to the cleavage furrow during telophase.
Sequence:
MNRSDGLVRRSVKPRENGGAEGGLNANTPDDNQDALDNLKDQEDNIDDGDSKETRLTLMEEVLLLGLKDKEGYTSFWNDCISSGLRGCILIELGLRGRVMIEKSGMRRRGLCTRKLILKSDQQTGDVLLDEALKHIKETDPPETVQSWIEYLSGETWNPLKLRYQLKNVRERLAKNLVEKGVLTTEKQNFLLFDMTTHPLSDNVVKCRLVKKIQDSVLSKWVNDPQRMDKRMLALIFLAHASDVIENAFAPLNDDDYEVAMKRVRELLDLDFEAESAKPNANEILWAVFMAFTK
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Domain:
The MATH/TRAF domain binds to receptor cytoplasmic domains.
Sequence:
MTSLISITLDELLINEDINDDYTCCVCECLLIEALQCRNGHVACKNCFIKIVKSKKECMTCRCEIKSIESLSKNRYLEKEIRKLNINCPNSFLKRELNLNNNNKNGNGNEGSSANEIEQPQQPQQQQPQELIKDINNGCKEILTIDQLDSHLKQCEYRFLKCTNLYANDLCSELDICGYDYRYNQSEKHRDECPYGIIGCTLCGKDCSRVDIESHTENHCPKLLVKCPTCNQDQLIARCDLDDHLSVDCAMIEIDCILKESGCKERVKRNQLANHLSSDNHLLFINNQFNQQNDIINQLKLELSHCNDLNEILTAKLDRYNNDNTMFRGKWVISNWTDKLNQYPPKKYLSLDFNLSQNKPFSIRVYPNGSSVMWHNCTISLVKLYQTESTIKFSFEIENEDPLKNDLQTKTDIFKGLNDSWSLQFFKVCDQANNNGFIINDTLTINFSIKIKKCFENIFITE
The following text describes a protein:
Function:
Plays a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAGKWRFTKLDAFTKTVEDARIRTTSGGIVTIVSLLVVLFLSWGEWRDYRKVVIHPELVVDKGRGERMEIHLNITFPKVPCELLTLDVMDVSGEQQHGVQHGVKKIRLRPQSEGGGEIDAKVLSLHAADESATHLDPSYCGPCYGAPAPYNAKKPGCCSTCEEVREAYAQASWAFGDGATMEQCQREHYTERLAEQRHEGCRIEGGLRVNKVIGNFHIAPGRSFSNGNMHVHDLAQWWSTPVPGGHSFSHIIHSLRFGPQLPDDLVRKLGGNGKNTLWTNHHLNPLDNTKQETNDPNYNFMYFVKIVPTSYLPLGWEKQAAQNKAAWEQDHSVGLGAYGYGSDGSMETHQYSVTSHKRSLTGGDDSKEGHGERLHSRGGIPGVFFSYDISPMKVVNREERAKSFLGFLAGLCAVVGGTLTVAAAVDRGLFEGTVRLKKLRSKDN
The following text describes a protein:
Function:
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSGGLLKALRSDSYVELSQYRDQHFRGDNEEQEKLLKKSCTLYVGNLSFYTTEEQIYELFSKSGDIKKIIMGLDKMKKTACGFCFVEYYSRADAENAMRYINGTRLDDRIIRTDWDAGFKEGRQYGRGRSGGQVRDEYRQDYDAGRGGYGKLAQNQ