lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Subcellular Localization:
Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
Sequence:
MASSSESVCDDQGDYQWPWCQMGHFGINFIQTDGSKAYVEGDLSRAYIKDYELLRASKRPKDQKLAEEKIQEDLDEMSLKEVESEANGDTVDDKILDEKDMAYEVLPKWTSDKRKGRKKKMKGRYNYRSFNEYWDVAYFYLTQMTWLNDFGDQMNEENKEKLRKKCEEMKPVYPIEQHENLLENPDYHHVTKSMIEPKQGATYEEIYAEHCELIKKKSEVDYHAHQTKSVTRRCKDMISRVKRLGYAPGFEESQLPSFYDLKTEQKHDKPLIKEIRYTIDDAFSKKFCGADSRDEKVEDSSASTSDSTSPSDSQPEMPSPVNPSEIRFNFDPETEKYLIASDAEKLYANDPEISKYYYQRYRLFSRLDEGIIMDREGWFSVTPEAIAEHIADRVVRHNVSVVVDAFTGVGGNAIQFALRGAHVIAIDMDPVRLKCARENARVYGVADYIDFICADFFDVSATWAADKKLAPKVDAVFLSPPWGGPSYLKAKEFDLATGCCPNGVDIFDVSLKISPNIAYFLPRNTKVSQLTELAIKAKSRMEIEQSSLNSKIKTITVYYGKLAYREKIPACDT
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MTKLVEISGLNIRFTGERTVYAVNDLSLSLGDGEVLGLLGESGSGKSVTLRALMRLLPKKRTQITGKVNVMGRDVLAMNDEELSSFRGQTVSMIFQEPALALDPVYTIGAQIAESVVRHEGKSYAEGRARALEMLEVVRIPSAKRRLDAYPHEMSGGMRQRAMIALALACRPKILLADEPTTALDATVQIQILLLLRELQREFGMSVIFVTHDIGVAIEICDRVAVMYAGQIVEQGTLRDIVRTPVHPYAKGLLASTIHGAKRGQRLETIPGTPPSLAEKPHNCSFAPRCAAAQPRCLEQLPANVEVGPGRAARCVLAEPVTAS
The following text describes a protein:
Function:
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
Subcellular Localization:
Chromosome, centromere, kinetochore. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
Sequence:
MGRLDTPLLLQRGHPKSDGLERMKKLDLSNLQLRTNDLDLQLLNRLKQLRELDLSDNLLERLPDGLDLPSLQVLRCTNNQLEDLTPLQQFPALEEVDFEDNLYLTVNDNYKIASLLPNIQKINGKETDSLLNHVKILTQELTGRVTAYWEKNYQDQLDSSAQTQDIHREFVKSAVKEVCFGPESLSDFTQWKVKMIAQKLVASKLTQNEAPSSPSTTSTPSSPSTTSTPSTLSEGSSRHESRVGSSIQQSLVKLQAFKWKKSLSGDHPPSKKARPSLAPDSPPAPREAGHSSASGSCRQTAPAEMEVEGQEPVELEPLHFLQCHSKGNSPDDFSTQLWACAFEPAWDDGTGRPGGASQTVATCGGEAVCVIDCEEGFVLHRYKVPGEEFFTVAWTTLTLVTGDGRKKRSNVLAAAGRRGIVSLIHVRAGFCYGVIRAHRKPIAMACFSPCQETHLFTASYNKRIILWDIGLPDHNYQFRPSQLLVLDTSATPLRLCPVASCPDHYLLGGCEDGCFAWDIRLTEPQKRRDCEMMFLFPQGPGRAHKRVDGLGFVSEDVVASKGCTPGSICLWSWSQSLAGRAGKQQVTVVILAELQWSHTELSYLTLSTCPEKAFVFCGDEEGTVWMYNVKHYLEQHPPSQASVAPTKILKWPDLSARGRKMNKTLINTAVVDPTFTYLVALTDTNIIAIWKKL
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTSYQAQCDQLLSSGKATGVAIINAIDGNTFVFGGSRFNLKDGEGGAIVSQFRYPKIALANGVIVNGIRYTAYKADSRSFYTRNGATGVALARAWKSIVIVFYNETISGPNAIFACEGAADALGKNRL
The following text describes a protein:
Function:
Involved in specific localization of cytoplasmic proteins during the formation of pole plasm. Required for synthesis and/or stability of oskar protein (osk) and localization of tudor (tud) in both the nuage and posterior pole of the oocyte. Required for normal posterior localization of osk in later stages of oogenesis and for posterior localization of the vasa (vas) protein during the entire process of pole plasm assembly. May act by regulating the complex that contains the arginine N-methyltransferase csul.
Subcellular Localization:
Cytoplasm.
Sequence:
MFPQRSSELYRTPVTHQPPPALELAGNLEYPNLNIADLNARLENLSPRLHDCWDSIAINDHNHLALATNRREGRQWWGMLFGYGRDQMHHMSVDSANFKLQAEHTVNIVRYAEDDFLLVALGDTRLQAWSTYSKVRDSQSPYCLFLVGESSAHPTPISQLSVFKADPRTAVSGSADSTLNVWDLSGADMVSTYRSRSSHTDKLTGLATPAASVDKFVTCDRGGCARLWDVRAAAPSSTCLYADASHVLSFTSAAWAAASELQGDNHIYLGDYDGKVHTLDIRVPRKLAETREYFDKGHVAQLLINGPHLAAMSNLPASVKVANVQAGHEFIYTHQDTHSRLTDAVWTDDSTLITIGHGRKMVTHAIK
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAMHFGEITTAFPGGGGIAGASTARTTPAASPYQAAVESEEQIYSPAFGNIEVQDSRGCCSGFTGSVTKLLFIFHLLAFIALTAFLGVQASYHQNPAYKPFSNFIPLVSSVIVSTIAACFWVILAVTNPPKAIKTSLWAAPVSALACDVVILLVGNTAALGIGALVVVFAIAAGLYSCWATGPRLKHASDMLSVSVIGAHLPPATSCLVVYVLLATFGYMAFWTVAISCIAAAEGHFMDYRMAYVAALLVSMAWTMQVLRYIVYVAVAKLAHGRLTYGIHVLGGAVEAFCDTIFGPAFGDICMGAVAVPVNSAVRGLARAMKTAAGGNDEFILSGQGCCFAVSEKMLGRANRWGFVHVGARGKAFCVASRDVWSLFVLRGIAELVDSDLTGSFCFLSSVTSGALASLVSGSWALAMDKDQKKLALPISIYAFLIGYYMCRMMIAWPQACVAAYHVAYAENPQNPQLGTLIPEHLRELQAMAADQDRPRVIHFSDDIDNS
The following text describes a protein:
Function:
Substrate-recognition component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations. Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium. Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1), malate dehydrogenase (MDH2), and other gluconeogenic enzymes, probably by targeting FBP1-containing vesicles to the vacuole, but is not required for FBP1 sequestration in cytoplasmic vesicles. Specific for substrates with an N-terminal Pro (Pro/N-degron), including FBP1, ICL1 and MDH2. Has high affinity for the N-terminal sequence Pro-Thr-Leu-Val, and can bind peptides with an N-terminal sequence of the type Pro-[Gly,Ala,Ser,Thr,Asp,Asn,Tyr,His]-[Ala,Val,Leu,Ile,Lys,Arg]-[Val,Cys,Pro,Leu,Ile,Trp]. Also recognizes nonproline N-terminal residues and targets an Ile-Gly-Lys-Trp-bearing protein for rapid degradation.
Miscellaneous:
MISCELLANEOUS: Present with 6650 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Colocalizes with FBPase-containing vesicles.
Sequence:
MINNPKVDSVAEKPKAVTSKQSEQAASPEPTPAPPVSRNQYPITFNLTSTAPFHLHDRHRYLQEQDLYKCASRDSLSSLQQLAHTPNGSTRKKYIVEDQSPYSSENPVIVTSSYNHTVCTNYLRPRMQFTGYQISGYKRYQVTVNLKTVDLPKKDCTSLSPHLSGFLSIRGLTNQHPEISTYFEAYAVNHKELGFLSSSWKDEPVLNEFKATDQTDLEHWINFPSFRQLFLMSQKNGLNSTDDNGTTNAAKKLPPQQLPTTPSADAGNISRIFSQEKQFDNYLNERFIFMKWKEKFLVPDALLMEGVDGASYDGFYYIVHDQVTGNIQGFYYHQDAEKFQQLELVPSLKNKVESSDCSFEFA
The following text describes a protein:
Function:
Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
Sequence:
MDTWTFLSVLLALTHYVSGQSTIRWCVISVAEESKCKAMAQAFSSASVRPALKCVLAASKAECAQKLTQKKEVDAFSASAKDIYDIGKLASFKIAAGESGSDGKGITYYGVAVVKKTNAAININNLKGKKSCHTGKNRTAGWNVPLGYLIDSGMMSVMGCNIPQGVADFFNASCIPGAKDDPASLCQQCVGDRTGQFKCDPSNKELYYAYDGAFRCLVEDAGDVAFVKHTTVSENTDGKGASWAQELQSKDYQLLCRDGTRSPVTDYEKCHLARVPSRGIVIHPDITTSVVYNMLTEGLQKSGFSMFSSADFGGENLLFSDTSTKFIQAGNENYKEWMGRYYHILKAMDCSQSDIPSQLQWCVLSHGEQQKCADMAVAFKNKNLIPNIQCVYGASVEDCMKKIQNKEADAITLDGGYIYTAGKSYGLIPAVGESYTGDSDGSIYYAVAVLRKSNRDIQRFSDLKGKRSCHTGYGRTAGWNIPMGLLIEKGIIRPQTCQVAQAAGEFFESACVPGADQKDFPENLCKQCIGDSSGQFKCVKGKDLYDGYDGAFRCLVENHGDVAFVKHSTVFQNTDGNNTDPWAVNLDSREFQLLCSQESRAEVTQFTKCNLARVPSHAVMIRPDTNHHIIFGLLDKAQRFFGVNSASDFKMFDSKAYEGSDLIFKDSTITLIGVGERKTYEEWLGQSYLDSLIAMECSASSTVFSFSSLLLMSIVSSLVSLLAL
The following text describes a protein:
Function:
May have a role in actin patch assembly.
Miscellaneous:
MISCELLANEOUS: Present with 1360 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MQQTKFGKMYLDHDSVVEYSEDEIVEADRITLGYKKRLSMIENQMRHLLEDFSLDVQQIEPILADLQKYYDAFLQLLQKRNKSLQCKRSTHQPVPSPMNSQTSTNAKVNLSGKLMKFQLNSVQKFDEENILRILQNKIEFEHYFQIDKGKKQKVLLLAVYQCLNGPTRLHKVLNIEGIIHNNSIRTILGKQVSSSKWTVFLYDVKLVLLAHRQDVPNLETSKMIVRYGDLFPCALYFKDHTAY
The following text describes a protein:
Function:
May act as a scaffold to regulate the recruitment and assembly of spindle midzone components.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Midbody. Note=During early anaphase, localizes along overlapping interpolar microtubules between the separating chromosomes. During late anaphase, localizes to the center of spindle midzone. Concentrated at the midbody during telophase.
Sequence:
MGCHNSKVCGQVSKKKKKNKAQEGEKRTKDIKLQDGRGTHSSEEERCCLENQLENYEWQLKILHAVLTASGDQEREQLLKDHPGDICTLVHSITEKVKTEISADLNDLHEQQMRSVSEQHQSETEELQRLHSEEKNVLNESHAAAEEALKDQIEDLTSELKLFNELKRRAEASTLKRDLQRNIETHGSPGEFWEQEQESLLFVIEMKRQNLQDQGNKLLQMEAQVEKNLSLEDQLLQALQQNEDFRVRIENYQSLIQQLSKEQNDMQEVLEKQSLQNQKLIQEKEELLFKLLHRRDSCSTFHLPSVIPTQVSPS
The following text describes a protein:
Function:
Activates transcription elongation by RNA polymerase II and pyrophosphorolysis as a complex with eaf1. Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.
Miscellaneous:
MISCELLANEOUS: Deletion of ell1 renders cells sensitive to the drug 6-azauracil.
Subcellular Localization:
Nucleus.
Sequence:
MIRNSSISDALPVALGGNEEESPLLMLVQLPKEFLEGYLSGTITDVSLECSDVGTSILANDRSYKCTSVPETAPHEIYRLVDSNSLQLVGRVSQKLQLRRELDSLTAERVKNRTQEAQKEKEEKRIVTLQNDGGSKNTTARKQKQLKKNGLRPLNTSASRIGLSSSPTNTPSPNLPVSQPSASPHYSGDKNSAKGIDLRTRVIQLLAIAPETEDFLRLRTKASLSKLQALLPEVAWKNNMNQWELLNPVYKDVRVFDWRPYSIADRNAVLSRMSNAFDNMQLPPDAPERSLLVSKQKNITKLNNEKRIPPQLAQPTSHVPSFIDTNSPSMPSISSVSSYQQQHRIPKLNASNYSPLLSPSSHRKTSGNLSRTGSESSAVSLSDTTNLNTPISDIPSPGSSTTCSNLSSPHIKRKSRSPPQSLPSTPFPTSSSSTNGTLEPNANSPKKNEQDAWIAKKRRQQRYTTEEMRALAKRFRETYPRYKNLYLKVSSYYDNNDTNNPNLNKLQDELISLHSQLKSWKNTLYDASSELAL
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).
Sequence:
MSALGSTEMRACQLPAAVELELAQLERRHDQRADPLAQRRLAELGEAAAVRVLQRIGRSRQPVQNLSAYIQWVMKHDSEERAAAGGSVPSQRGGDAVLGTVNHHIHISLDLPIHATINAGSPARSTHYSLQLPGSPGHGPVSGLQHQVGTESLVRHAIASPTTTVSSPSPVRNIVKSLHQLALGGLPRTVGAELATPPTPVHMMPADPLVNANTSKATANLHMTMMALGELEFDKVFLIYVYLGRNKTEDVCELREDYIRSLPSLSMKDSEPEIWHRFGHKFVAESDRRKNLDWGDSSKARVYHCCLEIADGSVVTIFKGPYLETSRNKLQKVVGDDNILVVKFSDIPGQRNFGNDVGAYYSVYHKVAEDGISLGLRRYRYLIHKDGGKEGKLKEGTEKFSSGVKCYFLRTESGWNRDDAYILSNKTIDEARKLFMHVHTVPTLAKYLARFALVLSKATTLLDANDLSKVNVIIIEDIPCKDRNGNIVLSHGEPLIHTDGTGLISEDIANKCPTSVVKGNFSRTPDLQVLSSDPGLEGRGLSSEPLLLQIRMFYNGLAVKGTLLVDRRLLPGTIKIRQSMIKTASDPNLRDEQSFNSLEIVSTSKYPKRAFTSRFLIALLHYGGVPADYFLELVRKALKDVEKACHKASYSLEVAYNHANLDDSMSARMILSGIQPEDDAYLQYQLAFMTREEREGIKLGRIPIEESYYLMGTSDPTGTLKPNEVCVIHENGQISGDVLVYTNPGLHFGDIHVLTATPIPNLEKEIVGFSKYVIIFPISGPRSLADEMANSDFDGDMYFVSRNPQLLEHFRPSEAWVPRNPPKKVEQKNPQHYDGPQLESLLFKEFLKSRFVPSYTIGTAADCWLVYMDQLLAGQVQENKRGMEIKDKTLDLVDIYYESLDAPKTGIKVDVPDALRVKKYPHYMEKGDDRSYHSTSVLGQIYDEAKALSEQSKDIPPINISPLACFTEVAVGVTKERKEEWKRLYDEYRGESTALCDKKYNKKYSKEERDAGFTKLYQKYRRMLYDAEEFDDSLRNYNEVFGEACAIYQIVYEYARRQNKATLCGFAWKVAGRALCHLHAIKRGGETVLCSQSVLRDAFKKNR
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLLAAPFLLTGFPGLEMFHPWISISFFVIYVSILLSNGTLLFLIREDHTLHEPVYYFLAILAATDLGVTLTTMPTVLGVLWLDHREISHGACYFQAYLIHSLSIVESGVLYTSILTNAQVVKMGLGLLLRGFILVVPIITTLSGFPYCRSHGLSHAFCLHQDVIKLACADITFNRLYPIVLVSLTGFLDSVLILISYILILKTVMGVASGKEQAKALNTCVSHISCVLVFYVTVTGLTLIHRFGKYVPQAVHIIMSYVYFLFPPFMNPIIYSVKTKQIQNGLTRLFSFQRL
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MVDSGFEKECYEIYNSYRKEWLEDLLINKLLALRKMEFQDYMIGRWIKTSKVALRILFPSERQLYDGVFSEFNSESSDHYFSDVCHGAIIQLLNFADSFANRSPSPWRMFKILNLFETLCDLIHEFESLFLDSLVNEAVKIKNRLGEISKDIFMEFGNMIFLTPYVELDCWADGGVHPMTCEATSSIVAAFWSRQNLEKILQGYPLVVDGAGTSLFYSQMVLIMEQFERKLEAKSKYYEDPALEDWKPFGIIAFIQTRKFFELYFRSSWNKVIDSLKIDITELVAPNSKANSMKNKLSLFNHKFRETCGIQSTWRVFDEQLRRQIIISIEISLFPAYEKFISMVQCCWKKCQ
The following text describes a protein:
Function:
Inhibitor of protein-phosphatase 1.
Subcellular Localization:
Cytoplasm.
Sequence:
MDPSSPSEGPVEPKERRKIQFAVPATEPTQLDPRQVEMIRRRRPTPATLFKVADQTSPEDDITSHQWVVGENGILKPKRINPNIYQPPSLKAVQQMAEAQMQKLGVYPHVEEEGEEPVHRGGAELCSSCTTESQEQRSTPEKQSGMRKTEATAPTDEEEEEEEEEEEEDEEKEEEEADDMAREESRNLD
The following text describes a protein:
Function:
[Drosocin]: Antibacterial peptide with strong anti-Gram-negative bacteria activity. Significantly contributes to antibacterial activity against Enterobacter cloacae but not Providencia burhodogranariea. Inhibitor of bacterial translation machinery that targets translation termination in a prfA- or prfB-dependent manner. Binds within the nascent peptide exit tunnel of the bacterial large ribosomal subunit, potentially interfering with nascent chain translocation that occurs post-peptide bond formation. Binds prfA/RF1 (and potentially prfB/RF2), trapping it on the ribosome after release of the nascent polypeptide chain and preventing further translation. The resulting depletion of peptide chain release factors further disrupts bacterial translation by preventing ribosomal peptide chain release and inducing stop codon readthrough. Entry into target Escherichia coli cells requires the bacterial peptide antibiotic transporter sbmA; [Buletin]: Peptide with significant antibacterial activity against Providencia burhodogranariea but not Enterobacter cloacae.
Miscellaneous:
MISCELLANEOUS: Unlike many antimicrobial peptides that kill bacteria using a lytic mechanism, proline-rich antimicrobial peptides can enter the bacterial cell to target intracellular processes; MISCELLANEOUS: 'Buletin' is named after Philippe Bulet, whose dedicated efforts in the 1980s-1990s characterized many of the Drosophila antimicrobial peptides, including Drosocin.
Subcellular Localization:
[Drosocin]: Secreted; [Buletin]: Secreted.
Sequence:
MKFTIVFLLLACVFAMAVATPGKPRPYSPRPTSHPRPIRVRREALAIEDHLAQAAIRPPPILPA
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MGSSEIVDSGKVTGQKSQFSQTCNLSSQFLKKKGSFGDLNNLGIYRSFEPTGNQTTTTTMNLLPMIEKSGDSAEKNSQKPMNLFPQEVISTAKSEPEKAQMTIFYGGQVIVFDDFPADKANEIMKLATKKTNNKQNLASNIFSYPMVNNQKSAESVTTNLTQEFRTRTHVPISQSSVADLPIARRNSLTRFLEKRKDRITSTAPYQIYNKKIADSKTEENKAWLGLGAKFVPVKTEQFF
The following text describes a protein:
Function:
Determines the virion's shape: spherical or filamentous. Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology. Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms; Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.
Miscellaneous:
MISCELLANEOUS: Most abundant protein in virion. When expressed alone can form virus-like particles in transfected cells.
Subcellular Localization:
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Sequence:
MSLLTEVETYVLSIIPSGPLKAEIAQRLEDVFAGKNTDLEVLMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDKAVKLYRKLKREITFHGAKEISLSYSAGALASCMGLIYNRMGAVTTEVAFGLVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRTIGTHPSSSAGLKNDLLENLQAYQKRMGVQMQRFK
The following text describes a protein:
Function:
Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.
Subcellular Localization:
Lysosome membrane; Single-pass type I membrane protein; Lumenal side.
Sequence:
MVSANKHTWISPLGFVVSVLLLNVALCDEPSKLQRKLTATLNPGCREFCENNTAITLVHIAATSDTDTIHYVWDFTGKPTILVALTSKQAEFHIDWPRLMESKPGSVRFTEAPQYTFMAIINRIFQYNDADDRAMLDEGTNAFVYDPHNFIWNRSLLWSNEEDVMMAINAGDDFLFKLNAYSTKDHGMDFPHLLHTSNSTQIDIVFNNITNRFANPRFAIELLFVVSEQAVVGSEFEVTKRKTLDDEHTPGIFEIVDVLSPGAFTFSAGGYIEYRPVSYTHPERDVATSTETRQSQPISVRSPSAVLQTTLAYALYGNKLDSYLVQGMNVSFGVSEDGFYRKTNYTTMTFQVGYGMPPVEELSAFVLIVAGIGIGVPLVVLIASSIYVCTKKLRNRDRFQQQRL
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MVKTIQLGSRLRYPITITKLYKEPNQPIKKKEALFQYSFKWKRTVGDNIRGETWEAEETTYADWSSPSDGELKSWKIRVGQEISRDQDCMVVKESCSHDVQFGGLCAICGKDMTEVNWAAESRDMDRAPINMVHDQTHLTVSETQAQKTENALQRRLLQHRKLSLVVDLDQTIIHACIDPTVGEWQKDPSNPNYPSVRNVKSFQLDDGPRGVANNCWYYIKMRPGLEDFLKKISTMYELHVYTMGTRAYAQNVARIVDPDKKLFGNRVISRDENGNMYAKSLQRLFPVSTKMVVIIDDRADVWPRNRPNLIKVSPYDFFKGIGDINSGFLPKQQGLLTPSAAATTNGGLARIAPAPSPDKEDSTTMEPPLEKALEEQEKTLEKQIKDRPLQALQEQQDKQDEAAERASATPESGNTESTTPPPPHHRHQVLQDDDRELAFLENHLTALHKSFFQAYEQNRLSQPSSSPSSLDTQSIPDVGSILTTLKAQALSGCKIVLSGIVPIGMDVYRSEIGLQVASFGAELRSSVTRDVTHLVVSSQRPRTKKVRQAIRYLPKIKIVNQDWLAACFSEWRVVEEGPYLIEGLEDAQKKLNEKVQDAEATETVSDADDTDSGNAPPGKKRILRLKSPPRVRFATAASTGNDEDEDEDEEDSDSGGDDEDEDEDMDEELEAFKPTDADGQLSPIDGLKTFNWGSADEELAEFLESGSDDEEEEEEDEDDDDGDNVNGDDDEEAPAQAATNITTTSSSYEQLLAAQGTAPSTKRKADDEEEEESHKRRKSLLGPGPSSLRNELKDEDVEATTAEVETQAAHDDQDVQYADDLDKEFEELDEEALEADFLAMDDGDGDEAQGQQVDGHGTGNGGVDENG
The following text describes a protein:
Function:
Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLVTAYLSFVGLLASCLGLELSRCRARPPGRACSNPSFLQFQLDFYQVYFLALAADWLQAPYLYKLYQHYHFLEGQIAILYVCGLASTVLFGLVASSLVDWLGRKKSCVLFSLTYSLCCITKLSQDYFVLLVGRALGGLSTALLFSAFEAWYIHEHVERHDFPAEWIPATFARAAFWNHVLAVAAGVAAEAVASWMGLGPVAPYVAAIPLLALAGALALRNWGENYDRQRAFSKTCAGGLRCLLSDRRVLLLGVIQALFESVIFIFVFLWTPVLDPHGAPLGIVFSSFMAASLLGSSLYRIATSKRYHLQPMHLLSLAVLIVVFSLFMLTFSTSPGQENPVESFIAFLLIELACGLYFPSMSFLRRKVIPETEQAGVLNWFRVPLHLLACLGLLVLHDSDRKTGTRNMFSICSAVMVTTLLAVAGLFTVVRHDAELRVPSPTGEPYAPEL
The following text describes a protein:
Function:
Required for normal Golgi function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MKNSVQRKINELKTLTNDPSNELIEALSSIDDTTFNSNTSVRTLLEEKELSELNRFIEQFSQLTTTIDRVFTTIDLLDKSCDQMLTKLSIGQKGVDEVLDMTTSLYIQQEKQRNQLTKIHSFIEEYYLSEEDFACLEKGDIDDKFFDAFSHLEASQERTSNALLTQKSRSLTDALTALNAAKERAYGRIHGWFHANSHIFNRLQPTIPSSFNKCLTIIKSKPILYGFVCSEIGQVRSSVIGPAFLNALTSPTADSRPLEETASADPLAFSSNVFAWIHQTAATEATFLATVLKEDQNSPNIQKTLDDAFESVCRPLDSRVSQAIRGLVRPADCFQMANICSYFFSKISDICGITSPVAKTTKNLVDMSSKTFRQAISESTDVIKSSVRPSQSAFHEALKIMKFVTSQHEQSSLSISFDVSSLIDNYAAQLHTTVVSMKENLPFQATYLYELSNLAKDANLKCSNDIEKDKDKVVAQIIDIEVSEFLRRCRSTELINLFTSPQQKPLSTVAGGEENLVRNTVKRLENALIGTGKLQTPLCDELSNNELKKLAKEEVSKKLVNAYKILFDSVMDARNGYLNGGTIFKYTPEHIKESISV
The following text describes a protein:
Function:
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Enzyme has a broad specificity.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MSSARLLESQTSDEDNEDIERRPHQSHSRSCSNNTTPTHPPHPMVRKGGVARRICLIGGALFLLLVALCYLTLSGDTRLGGSEDSEEGSHHGLDSMNFRPLNETVHICSESYEDRRQFMQDKPQSDYVQLPVIYFVTPTYPRREQIPELTRLAHTLLHIPRLHWLVADDQEKCNDYMDTLLYRFGMPFTHMVSPMPSKFRNEKPAPRGVANRRAALQWIRQHNLTNGILYFGDDDNTYDLRLFSEIRKTQRVSMFPVGLIADYGVSGPVVRKGKVVAFLDSWVAGRRWPVDMAGFAVNLEYMAQYPYVNMPYKPGYEEDLFLRSIGLQMNLIEPRGNNCTEILVWHTQTKSKKLGMVRLESKYLDDRSNLGALLHNLKLMGVTSTTESEGRNALISKNGRENPHSKILS
The following text describes a protein:
Function:
Acyl-CoA dehydrogenase that exhibits broad specificity for linear acyl-CoA substrates, with a preference for long-chain substrates.
Sequence:
MSHYRSNVRDQVFNLFEVLGVDKALGHGEFSDVDVDTARDMLAEVSRLAEGPVAESFVEGDRNPPVFDPKTHSVMLPESFKKSVNAMLEAGWDKVGIDEALGGMPMPKAVVWALHEHILGANPAVWMYAGGAGFAQILYHLGTEEQKKWAVLAAERGWGSTMVLTEPDAGSDVGAARTKAVQQADGSWHIDGVKRFITSGDSGDLFENIFHLVLARPEGAGPGTKGLSLYFVPKFLFDVETGEPGERNGVFVTNVEHKMGLKVSATCELAFGQHGVPAKGWLVGEVHNGIAQMFEVIEQARMMVGTKAIATLSTGYLNALQYAKSRVQGADLTQMTDKTAPRVTITHHPDVRRSLMTQKAYAEGLRALYLYTATFQDAAVAEVVHGVDAKLAVKVNDLMLPVVKGVGSEQAYAKLTESLQTLGGSGFLQDYPIEQYIRDAKIDSLYEGTTAIQAQDFFFRKIVRDKGVALAHVSGQIQEFVDSGAGNGRLKTERALLAKALTDVQGMAAALTGYLMAAQQDVTSLYKVGLGSVRFLMSVGDLIIGWLLQRQAAVAVAALDAGATGDERSFYEGKVAVASFFAKNFLPLLTSTREVIETLDNDIMELDEAAF
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MHGQSKSKTETLSEEEIKQRAEKGQQILDSLHYFFKVRKNQVNQPEDQLAFSELMAKLCPEIATIYNYRREVLQTKFDHLGGLLKESKSIDAYKQLLKLIQSEFMLIAILLKQHPKSYTLWTHRQWMVLRSQEIDSLINSINQDDQFKLIEAIRQEYELCSKMLDRDERNFHVWNYRNWLSSISAFGKEDEFTKKKIEQNFSNFSAYHFRSKYFMKNYNQSENILERIKTEQILGLLPLPFNRLKEETELIQQAIYIQPKEHGVYLYHRWLAGVVQPYGVTKVEKVSNNSITLSFNRAVTNVENTFEIFNKENALKIINVRVEGSNAIISFEEQQVDNLKIKIHNQIYENGSLETTMSEDESSKFLIPSEIDITINNEGFTFTNTTQKEFQDATQEIYKYLDENIDFIKQVIEEEKENRFPYIQLLYLLQFKLRTQRLIDESKTSEIIKEALQHCQQLKKIQNDHQAQFLYDFWSQF
The following text describes a protein:
Function:
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Sequence:
MPVAKGGGEGMEPHEYIHGIPAWVLKDFCQKMDCLHDYDWMRFASHVITDQTELRKIKCMEKAGISRTRELMWWWGVRLATVQELLDLLQELQLYRAAQVIANWKSISLAHDSVKPPQQENLSLYPNGNKLKQLPNEPEGQASLYTDPVFKRDGNIHPLSPPPTSMDLPHSLHSIPPDLSNRKLCSASVPQEEIAPHLPKSESLLWSPSEVETATNGFSRESQISEGIFAVTYKGWRDNALYVVKKLKEDQTERFFRTEVQICFRCHHPNILQLLGFSVESVSPCLIYPYMPNGSLMDRLQCQGGSESLTWTQRIKISLGLIQAIQHLHRFGILHGNVKSSNVLLDADFVPQLGHSGLRLHPIEKKTDRAMMKTKVLQVSLAYFPEDFVRHGQLTEKVDIFGCGIVLAEILTGMKAMDEERYPVFLKDVLLEEIQAAKKLSSSKERTFEQVAAMEIYHKYQDKQAAGLPETAGVHLAMAACVCLRKKNADLAEVKEIVEMAHRQMQHQKMTQGSSCFGPSINIPEETNDEPASSFIDGFPVNSNYERNSVSLNCNDLLPPLTRATVPETYSMQMLHVPCESDESSNFFWDPMEDADCQLQRRSHQHLENTSLAGPLPSDLECNNNFTTENTNFGQSMKLQEEAVSSSTAPGCSSQAEAKEIKINSAKKKLVEQILLYEENKINSYELFDSSV
The following text describes a protein:
Function:
Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPGHELEDVINQRLNLYDVLELPTPLDVHTIYDDLPQIKRKYRTLALKYHPDKHPDNPSIIHKFHLLSTATNILTNADVRPHYDRWLIEFLRKTNDIERNKLIQKLEESESSTIPTTTPHPDLLQIQRHGELLRKLKHFNLPYGDWKHLNTQDQENASQHPYYDCSTLRIVLDNFLQSNNKSNCLSHLRNQVFITLSANEIYDIYFSERNNYSKDDSIIIYTVFDTPITAQHVFRNWSSGNLIPTVKDISPLIPLHYYSDFNLETELNDDIARLVSNEPILLD