lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.
Subcellular Localization:
Host nucleus.
Sequence:
MSMTASSSTPRPTPKYDDALILNLSSAAKIERIVDKVKSLSRERFAPEDFSFQWFRSISRVERTTDNNPSAATTAAATTTVHSSASSSAAAAASSEAGGTRVPCVDRWPFFPFRALLVTGTAGAGKTSSIQVLAANLDCVITGTTVIAAQNLSAILNRTRSAQVKTIYRVFGFVSKHVPLADSAVSHETLERYRVCEPHEETTIQRLQINDLLAYWPVIADIVDKCLNMWERKAASASAAAAAAACEDLSELCESNIIVIDECGLMLRYMLQVVVFFYYFYNALGDTRLYRERRVPCIICVGSPTQTEALESRYDHYTQNKSVRKGVDVLSALIQNEVLINYCDIADNWVMFIHNKRCTDLDFGDLLKYMEFGIPLKEEHVAYVDRFVRPPSSIRNPSYAAEMTRLFLSHVEVQAYFKRLHEQIRLSERHRLFDLPVYCVVNNRAYQELCELADPLGDSPQPVELWFRQNLARIINYSQFVDHNLSSEITKEALRPAADVVATNNSSVQAHGGGGSVIGSTGGNDETAFFQDDDTTTAPDSRETLLTLRITYIKGSSVGVNSKVRACVIGYQGTVERFVDILQKDTFIERTPCEQAAYAYSLVSGLLFSAMYYFYVSPYTTEEMLRELARVELPDVSSLCAAAAATAAAPAWSGGENPINNHVDADSSQGGQSVPVSQRMEHGQEETHDIPCLSNHHDDSDAITDAELMDHTSLYADPFFLKYVKPPSLALLSFEETVHMYTTFRDIFLKRYQLMQRLTGGRFATLPLVTYNRRNVVFKANCQISSQTGSFVGMLSHVSPAQTYTLEGYTSDNVLSLPSDRHRIHPEVVQRGLSRLVLRDALGFLFVLDVNVSRFVESAQGKSLHVCTTVDYGLTSRTAMTIAKSQGLSLEKVAVDFGDHPKNLKMSHIYVAMSRVTDPEHLMMNVNPLRLPYEKNTAITPYICRALKDKRTTLIF
The following text describes a protein:
Function:
Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor (CF I).
Subcellular Localization:
Nucleus.
Sequence:
MTTKQWGITPPISTAPATEQENALNTALINELKNQNLFESPAESEKRVKVLDELQQITTEFVKKVSLAKHMNEKMANEAGGKIFTYGSYRLGVYGPGSDIDTLVVVPKHVSRDNFFQDLEPMLREREEVTDLAAVPDAYVPIIKFKFLGISIDLIFARLSVPRVPRDLELSDNNLLKGVEERCVLSLNGTRVTDQILQLVPNRAVFKHALRAIKFWAQRRAIYANVVGFPGGVAWAMMVARICQLYPNAVSSVIVAKFFRILHQWNWPQPILLKPIEDGPLQVRIWNPKLYPSDKAHRMPIITPAYPSMCATHNITLSTQTIILREMVRAGEIADQIMVKALPWSALFQKHDFFHRYKHYLTITAAAKTAEAQLKWAGLVESKLRHLVTRLELVDAIALAHPFNKGFDKVYNCSSEEEAQQVASGVTLEVAYESTDHEKLANDTVNEEKADNTESKADGSENGEKQIFPVYTTTCYIGLELEKKKGHPIKRLDISWPTQEFYELCKKWDKYDDTLMNVFIKNTKNTALPDEVFEPGEERPKATKKRSTADTAHSTEQLKRQKVSTA
The following text describes a protein:
Function:
When expressed in E.coli with Synechocystis PhaE and C.necator PhaA and PhaB, confers the ability to synthesize up to 13% (w/w) poly(3-hydroxybutyrate) (PHB) depending on the carbon source; all 4 genes are necessary for PHB production. Cell-free in vitro coexpression with PhaE gives a heterodimer able to polymerize 3-hydroxybutyrate-CoA.
Miscellaneous:
MISCELLANEOUS: Nitrogen-free medium induces chlorosis in Synechocystis, leading to the degradation of the photosynthetic apparatus and concomitant accumulation of cytoplasmic polyhydroxyalkanoic acid (PHA) granules which in this cyanobacterium are composed of PHB.
Subcellular Localization:
Cytoplasm.
Sequence:
MFLLFFIVHWLKIMLPFFAQVGLEENLHETLDFTEKFLSGLENLQGLNEDDIQVGFTPKEAVYQEDKVILYRFQPVVENPLPIPVLIVYALVNRPYMVDLQEGRSLVANLLKLGLDVYLIDWGYPSRGDRWLTLEDYLSGYLNNCVDIICQRSQQEKITLLGVCQGGTFSLCYASLFPDKVKNLVVMVAPVDFEQPGTLLNARGGCTLGAEAVDIDLMVDAMGNIPGDYLNLEFLMLKPLQLGYQKYLDVPDIMGDEAKLLNFLRMEKWIFDSPDQAGETYRQFLKDFYQQNKLIKGEVMIGDRLVDLHNLTMPILNLYAEKDHLVAPASSLALGDYLPENCDYTVQSFPVGHIGMYVSGKVQRDLPPAIAHWLSERQ
The following text describes a protein:
Function:
May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAAAWPSGPSAPEAVTARLVGVLWFVSVTTGPWGAVATSAGGEESLKCEDLKVGQYICKDPKINDATQEPVNCTNYTAHVSCFPAPNITCKDSSGNETHFTGNEVGFFKPISCRNVNGYSYKVAVALSLFLGWLGADRFYLGYPALGLLKFCTVGFCGIGSLIDFILISMQIVGPSDGSSYIIDYYGTRLTRLSITNETFRKTQLYP
The following text describes a protein:
Function:
Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX (By similarity).
Subcellular Localization:
Mitochondrion intermembrane space.
Sequence:
MSIAETNTTTEVAAPKKKMCCACPETKKVRDECIVANGEEKCAALIELHKVCLRKEGFDV
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF9.
Sequence:
MKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
The following text describes a protein:
Function:
Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTAPTVPADQHGHPLPGPADPAANDTWRPSRYREPLHPDNEEVLEQAAYQAAVTRSSGDDRKRKIKPRRTVDYQGGVQKWRMLNKLKGVHEFRPAIHPNPSDIVNFLPPVALRSNPSTSICDYWVHTSINKERSPTRVVRWTPDARRLLTGNDKGQFTLWNGASFNYESITQVHDDSIRSFTYSHNGQALVSADKGGTIKYFTPHLTNIHGFQGHREACHDVSWSPNDERFVTCGDDGLVKIWSYREAKEERSLSGHGWDVRCVDWHPTKGLIVSGSKDMLVKFWDPRTGKDLSTLHSSKSTINTCRWSPDGHLVATAGQDSVIRLFDIRTFRELEVLKGHEKEVNCIEWHPIHHSLLVSGDALGTINYFSLLSPTPSTPITTLSAAHEDAVFSLSFHPLGHILCSGSKDFTARFWCRARPPGGQEFDKWHLTEEGAAQKELERITKREWGTNAPPANAAGGGGGGGGDKQQVALPGLSNLVAAVNSVKTGPTTTGGGPSGLPGLGAPNVHAGTPPSRVSTPSSMGPPGPGAQGQAQGGQFPRGRSALPSQNDMLRHNHGSRGGFADRDRNGGGDRGGMDRDRDSRGGRQDPRGNQMYGRGPGGPPPGPPPGQGGYNYPPAPPNYPPYPPSSYPPPPNNQPGYPPAPNYAMPPGPGAPPQSYPYNRPPQGPPQNNNPGGQGNYGASASGGYGQYGGGGGGGGGGGYGRDGRR
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Golgi apparatus.
Sequence:
MEVQKIWKSFLNAISKVFSKGKKLRCTCFPKRKKEASERSCFPFLDTETISSCDLSDDVLSPKLFAKNSYRCSLKETKCIDVIVSHNSLAPQFTEIRYTDGISAKAENTDEMTMHIALAPLTENQ
The following text describes a protein:
Function:
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
Sequence:
MSSEEQEDVDEDIQYFVRIGQTDLDGTKTVERALAELGGVGRRVARIVADEAGVDRTATMGGLEDDAIESVTDAVDSFTEHAPAWLANRQNDFYTGENQHITGTDVELTRDQDINRMRMIRSYKGIRHERGQKVRGQRTKSTGRTEGTIGVNVEAIKEEQAEDDAADGGEE
The following text describes a protein:
Function:
Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27.
Subcellular Localization:
Cytoplasm, perinuclear region. Cell membrane; Multi-pass membrane protein. Cell projection, axon. Note=Expressed in neuronal cell bodies and axonal fibers.
Sequence:
MNPVYSPGSSGVPYANAKGIGYPAGFPMGYAAAAPAYSPNMYPGANPTFQTGYTPGTPYKVSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQSPYAQQGTYYTQPLYAAPPHVIHHTTVVQPNGMPATVYPAPIPPPRGNGVTMGMVAGTTMAMSAGTLLTAHSPTPVAPHPVTVPTYRAPGTPTYSYVPPQW
The following text describes a protein:
Function:
Plays a role in the extension of dendrites from phasmid ciliated sensory neurons. May be necessary for initial assembly of the cilium.
Sequence:
MSIFGSILSLQDAINRFPQFEYQINRLEKEQKDTEAASRASFRKHFVRQCQELHRQLDDHRNRIEKAKTDETYKKENALEQLDKLKQRLTALSPEKEQLSFSVSVDSQSEEEKPKMAAIGRRKSTMYNDDESEDSDNDSEIIETDVQLDDPLPSQPQPPQQQHQQPQPKPRQPITITKPLESKTLNERQELDEVISRLQNPSRGDSGEVMEPVVVRGNVFVAIDSWDAEAEGDLELIKGKKYRITQTRSDGWWTALDEYGQRGLVPKTYLQHVKEKPKNVPSKVSSRLGVRDSVIGISTTTDPSRREANRQASRVDDCLGKAYDNDTHLSLVCHMAPRLSTSNIGFHDLFWSHYKDQVYKRTVHISKIIRLVRFEKMPLIEHKALVRMALVDITNPKSTQIVSNVHTLVPRVKSSTWYFEKKESQTRSCIEFSDFVLRSNYRSPTVVLVVEASHLVKTQIGIEEKSLGHTYLRLIIDDKAVPSRTNVLYLDDEVMTKMKLPEASKRRVLVQVMDVPKDKVSYVDSLPDVIVFNALYLPFFHFYRRRAGTILIRDNRNPLSAEFISDPLLSVFPFVCDQHDIMDIMLKIWKTKKKVLAKKNEAEQTAEFFQTFLHTAFFIHGIRMISYDVKDDLTLSIRQQTMQRFVDALNKGLFKQFIADQQCKPINIIDYSLDLLGNHSID
The following text describes a protein:
Function:
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
Sequence:
MDLFKFFSKQSSKDVAKERLKLILIQDRNSISPDVLESIREDMLKVISKYIEIDNEDVDIKMSSVEEIEGMSPALIASIPIKRIKKK
The following text describes a protein:
Function:
Converts the prephenate produced from the shikimate-chorismate pathway into phenylalanine.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MIPQRQTSGTATRRNGHLCGHPILPFIKISELDVDGRQFLAVGIRKSRDRVPRNSDRVPRNSRWVPRNSRWVPRNSDRVPRNSRWVREGVDDTAGAAEFVAKHGLRDTAVIASYRAAELYGLQILAEGIQDDSDNVTRFVMLAREPIVPRTDRPFKTSIVFAHDREGASVLFKVLSAFAFRDINLTKIESRPHRNKPLRLVDDTNVGTAKRFEYMFYADFEASMAEVRAQNAVSEIEEFTSFLRVLGSYPLDMTS
The following text describes a protein:
Function:
Probable lipase that recruits the AP-1-related (AP-1R) complex to membranes via interaction with APM2. The AP-1R complex is an adapter protein complex that mediates of cargo protein SNC1 sorting in clathrin-coated vesicles.
Miscellaneous:
MISCELLANEOUS: Present with 1110 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Multi-pass membrane protein.
Sequence:
MSDSEEDLGVQLKGLKIARHLKESGEHTDEESNSSPEHDCGLSNQDDLTVMHTQAKEEVFKRREEDGTRTEDALHEGEAGKEGTGFPSSQSVCSPNEADSGIDRADKPILLDPFKSVHDTDPVPGTKSRSNSDSDSDSDDGGWQEMPAVSSFNIYNHRGELELTSKVRNSEQASETSPTVPPGKNCKSVNDSRFDYTKMAAEQQAQRSYRTNKKTDFLFDHKVLKKKINSSQTSVNLTSSPSTTSLNNEKNNDDDDDDSYDEYEDDVEPVNDLNRDSQLNITKNLLSDMEKFAYVGAINILANQMCTNLATLCLCIDIKSHKKLAHRLQFTQKDMAAWKTVVLSRLYDHLGISQEEIVMIEKLSLHKIQLEDLCKCLKTTQSIDNPWENDRDHEEDGIEETTERMSPNEQNGSVQASTPDPEQSATPETPKAKQSPLSSDVPGKVLDPENVKSQDKLNIDVAWTIICDLFLICLQSSTYDSRSRTLLINFAKVLNMTSLEICEFERRVTDSLDMEQSTEDQVWDEQDHMRNRRRSKRRKKMAYVALAMVGGSLVLGLSGGLLAPVIGGGIAAGLSTIGITGATSFLTGVGGTTVVAVSSTAIGANIGARGMSKRMGSVRTFEFRPLHNNRRVNLILTVSGWMVGNEDDVRLPFSTVDPVEGDLYSLYWEPEMLKSIGQTVSIVATEIFTTSLQQILGATVLTALISSIQWPMALSKLGYILDNPWNVSLDRAWSAGKILADTLIARNLGARPITLVGFSIGARVIFSCLIELCKKKALGLIENVYLFGTPAVMKKEQLVMARSVVSGRFVNGYSDKDWFLAYLFRAAAGGFSAVMGISTIENVEGIENINCTEFVDGHLNYRKSMPKLLKRIGIAVLSEEFVEIEEMMNPEEVKRKRKLINDVDAAQKKLSERKKHNSWVPKWLKPKKSKWKVMVEEAVEEGRDMQDLPENDVNNNENENPDEHEGIARQKRRDAALVDHGALMHELQLIKQAMHEDEIKNKACLPGEDKEVESSNDFLGESHYKPPSTPKINPPQSPNNFQLLSAGRTILPEDDDFDPRGKKKVEFSFPDDI
The following text describes a protein:
Function:
May link secretory vesicles to actin filaments (By similarity). May function as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle.
Sequence:
MGRKLDLSGLSNNEAEHVLRVVQRDMQLRKKEEERLSEMKQELEEEGSRCLLLSKQQKFNEHCCIRCCSPFTFLLNPKRQCLDCHYNICKSCCSYSQSERGYICAACQKSRHLRTQSLEWFYNNVKSRFKRFGSAKVLKTLYRKHIIERGALSELPEVSAHEGSNDNGSICDGSDSTLYKQSEGHSMADTLTVALRVAEEAIEEAIAKAENYKDSLEKQNEARYLHEHKEELIEELATTIVQKIIQRGKRPEIQEEYEFVWPQNQKSELPSPTSTQNPLATQNSHSTSQPGAVAQSDISKRSRSAYSSDDSPEKGPEVGMAPGVPKSTEVETDIQNYSSLRRESRALSLPGWKSVDRLENSSASSVLQSPDGNWIALQSSQHSRPSLLTKRKSLVFSVLEKESGVVSAYDEMGSDSDPEDQGGWGAALLQFRRRLSDETYYTDSQHDPEWTFTQHPPITSPSSGQYTNTETLNSDSETSPSPSTRARRAPVMKKGPPETHLYPYYRHPADIVALPQLKPDVLDVNFNPHLGGDSSDGEERSEQVKRSRRRRKSKRETSEHSRAHNALYSAATAENSTVLLNAMMMRRQQSQENTVPLNHQTPDSVTSPDILTFNNMSPEPEYQNTLAHNSSAASLPLLSQLGSNNPGFAPQDPLLRAFPVNETLEEELKYKLSELIGQVSERDVKSSDFEPISEVGNKQEDRVSEKDSGKLRPKERRESKRESKLREMEKQSERQTVKLMDTSDAVRQINIERQMKKERERQRDIERQVERERERQRELEKQIEKDRERRREIEMQVEKKQERQKEMEKQLKQEQERQSEIERDLEKKRKSIRMEKRN
The following text describes a protein:
Function:
Commits homoserine to the methionine biosynthesis pathway by catalyzing its O-acetylation.
Sequence:
MTTEQPTARLQRVDSQPENPFSALIEDQSIVIIPTFTLESGVTLYNVPVAYTTRGTLSPSGDNALVICHALSGSADVADWWGPLLGGPGQAFDISRFFVVCLNSLGSPYGSASAVTYKDGNPEKGLYGPEFPLTTVRDDVRIHKMVLDDLGIKQIAAVVGGSMGGMLTLEYAYFGKDYVRAIVPIATSARHSAWCISWGEAQRQSIYSDPKYENGYYSFDEPPAAGLGAARMSALLTYRSRNSFESRFGRNVPDPSKRQNINGTERLPTPPNEHWAIHNDGHKGNWSGRNSPAPEKPAEKTEVQYMDPQFSGTKTFSKSVSTTDGNAQKRPATYFSAQSYLRYQGDKFVKRFDANCYIAITRKLDTHDVSRHRARPDSENPVREALSQIQQPALVLGIESDGLFTFEEQKEIAEGIPDSRLKRIDSPEGHDAFLLQFEQVNQYILEFFREVLPDIMSKTPTDGAAIDGVGKLTKSSTFGEAEVEDITAW
The following text describes a protein:
Function:
Protein kinase that is responsible for triggering spore germination in response to muropeptides, signaling bacteria to exit dormancy. PrkC is thus a germination receptor that binds peptidoglycan fragments containing m-Dpm (meso-diaminopimelate), which act as spore germinants. Probably autophosphorylates and phosphorylates FusA (EF-G, elongation factor G); the latter modification is likely necessary for germination in response to peptidoglycan.
Miscellaneous:
MISCELLANEOUS: PubMed:18984160 shows that peptidoglycan fragments serve as a novel mechanism of interspecies bacterial signaling that likely indicates the presence of growing bacteria and thus serve as a signal for dormant cells that growth-promoting conditions exist.
Subcellular Localization:
Spore membrane; Single-pass type II membrane protein. Note=Is associated with the inner membrane of the spore.
Domain:
The C-terminal extracellular domain containing the PASTA repeats binds peptidoglycan.
Sequence:
MLIGKRLNDRYKLLKMIGGGGMANVYLAHDDILGRDVAVKILRLDYSNNEEFIKRFHREAQSVTTLSHPNIVNMYDVGEEDGIYYLVMEYVPGQTLKQYIIERGMLPIGEALDIMEQLTSAMAHAHHFEIVHRDIKPHNILIRADGVIKVTDFGIATATSATTITHTNSVLGSVHYLSPEQARGGIANKQSDIYSLGIVMFELLTGRQPFSGESAVAIALKHLQSEIPSPKRWNENIPQSVENIILKATAKDPFHRYQSANAMKRDIETALYPERINEQPFYIPEDMEATKAIPIIQQEQLFENVTDETIVLKGSKVDEQIRKEETDLSKKKKRSNKWLKILITTFLLLAIGITLALTVIPGFFIPKDVKVPDVAGMKYTTAVNTLVEKGFEVTEPNIVYTDDVETGDVIKTDPVAGRVVKENSKITIYQSGGKKKSKMIDFTGKDLESIRTELEEKYKQVTVYYIEDDRPKGAIVEQIPTSDQMVVEAEQELKIWVSKGPYQIRPGDFSRWTENSVTGYLNERKLTPDIKREYSDTVDKGLVISQSPKPGTPLKEGDKVTIIISEGPKPKVTKTVKVDNISIPYESSIIGEKKPQTIEIYKEDMQQKMDRPIETRTISESATISLEFVIQEDTKGRYKIVRDGVTIIDKEVPYPTQ
The following text describes a protein:
Function:
Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MKSPDEVLREGELEKRSDSLFQLWKKKRGVLTSDRLSLFPASPRARPKELRFHSILKVDCVERTGKYVYFTIVTTDHKEIDFRCAGESCWNAAIALALIDFQNRRALQDFRSRQERTAPAALAAPAEAAEAAVAAAASEPSGPSPQPKPRTP
The following text describes a protein:
Function:
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.
Sequence:
MRATLVARVASRIMAHVVDKPLICVFGATGTGKTKLSVQIAKHLGGEIISSDSIQVYKGLDIASNKATSEERQGIPHHFLDELQMDEQLTMPEFRDRALQLIKQMHQNNQVPVVVGGTHYYVESLMSVTASDLLESDSETATAETKRTDAQIEVAAIPDDDLYNKLKLVDPASAARLHPREHRKLRRSLEIAMSTGTTQSALIKQEQALGSPLRFRPTLCFWAVLERRLAKRVDEMVAQGLVHEIFGFLATLVHREVVDTRQRPTRVLGQLNFQHGILQAIGFKEFLPLFEHVINRGWLEEVFASKKPTIVNQQAWQELDELLIQKPGSTLLAKGIEQVKVSTARYAKRQQTWIRNRLLRERDQLFVYKMDSSQPSTWEDTVWQPALQALKAMQAQDPLPGLALQPWPTATPVAEAPIEHTCSLCERSFYSTRDWESHLASRAHKKRIAGAKRREENERRRQAKRSAEASREATGADSTEDTS
The following text describes a protein:
Function:
Required for efficient DNA replication, probably through involvement in telomere replication. May have a role in telomere capping of heterochromatic chromosome ends.
Miscellaneous:
MISCELLANEOUS: Multiple telomeric fusions result in multicentric linear chromosomes that resemble little trains of chromosomes, hence the name 'pendolino', the name of an Italian train.
Subcellular Localization:
Nucleus, nucleolus. Chromosome. Note=Associates with multiple polytene bands and interbands on chromosomes.
Sequence:
MTLDLDAHKKDDKLLITTIQQEYKILAEYKMIESEKLSGIYVIPSYANSLQWFGVFFGRQGLYAESVFRFTILLPDRFPDDKSLPSIIFQQDVIHPHVCPYTHSLDVSHAFPEWRCGEDHLWQLLKYLQVIFSDPLDSIRGIEVDKLKNSEAAELLMNNKEEYVARVQENIKESKEHIFDTPPTEDPHYIVFEKFQQDVHGPVLERIKAGRSKLTEPSAQQANGGHATGLSWVKEGEFKPLSIE
The following text describes a protein:
Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Zona pellucida.
Sequence:
MRGHAGSWGLVVALGLCSLLSCVQGFWDGLHCGPTNMQFSVPSLVQDVAFVLSAVDHTGKSHYLANNTACGTWVGQKSDGSLVVDAAYDGCFVHEENGDHVMTVSLEEVINGHVDYHKQELKCPVMEAMDVPSPDTCSAIKREDRLSCAKAPVSQDLCQGLGCCYTSSDPTMPCYYGNKLTAQCSTDNNMMVAISKDLTKPSLSLNSISVVGVTQTSCQSLSVSKTNAFIMFQFPLSCGATKLMDGNVITYESTFVSARDIRTWRGSSITRDSTMKLTVRCIYGRTGIAPLLKVEVYTLPPPPPISTPGPLMLEMRIARDMQYTTYYADGDYPVIKILRDPVYLEVRVLRRLDPNLVLVLNNCWATPSTDSTAQPQWPVLTSRCPFPGDNYITQMIPVGAATQAVPFPSHYQRFSISTFTFVDGTTQLPLGGMVYFHCSASVCIPSAADTCRIVCNTRKRRMAEESPAVYPLETTVTSDGPVDFIDGEEKRTETEGVVGFGYPVLQWARGAAAIGGVLTVTVTFIGLWIHYRNRSPKTHDVNA
The following text describes a protein:
Function:
Plays a role in cell migration. May be involved in neuron regeneration. May regulate IL2 production by T-cells.
Subcellular Localization:
Nucleus outer membrane.
Sequence:
MPVLGVASKLRQPAVGSKPVHTALLIPSLGTTGPQRSSSRPLELTELESSMLSCQLTFKSNCESEEKKPLQGKAKETEDSKIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLAEIIQIIANEKVEDINGCPRSQSQMIENVDVCLSFLAARGVNVQGLSAEEIRNGNLKAILGLFFSLSRYKQQQHHQQQYYQSLVELQQRVTHASPQAEASQAKTQQDMQSSLAARYATQSNHSGIATSQKKPTRLPGPSRVPAAGNSSKVQGASNLNRRSQSFNSIDKNKPPNYANGNEKDSSKGPQPSSGVNGNMQPPGTAGQPPASAIPSPSTSKPWRSKSMNAKHSATSTMLTVKQGSPTTSPTPSADRLKPPASEGVKTAPSGQKSMLEKFKLVNARTALRPPQSASSGPSDGVKEDDAFSESGEMEGLNSGLNSGGSTNSSPKVSPKLAPPKAGSKNLSNKKSLLQPKEKEEKNRDKSKVCTEKLVKDEKDQMMETAPKKTSKIASLIPKGSKTTAAKKESLIPSSSGIPKPGSKVPTAKQTVSPGNSASKESEKFRTTKGSPSQSFPKPITTEKASTSSCPAPLEGRETSHASLAGSSVGLVVQGSGQSMGNGAVQLPQQQQHSHPNTATVAPFIYRAHPENEGTSLPSADSCTSPTKMDLSYSKTAKQCLEEISGEDPETRRMRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDSTVTTEVNGRTIPNLTGRPTPMTWRLGQACPRLQAGDAPSLGAGYPRSGTGRFIHTDPSRFMYTTPLRRAAVSRLGNMSQIDMSEKASSDLDMSAEVDVGGYMSDGDILGKSLRTDDINSGYMTDGGLNLYTRSLHRAPDTTASRDVIQRGLHDVAVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSVSSYSNITVPSRKNTQLKTDSEKRSATDEPWESTEELKKPEEDFDSHGDGGGKWKGVSSGLPEDPEKTGQKASLAVSQTGSWRRGMSAQGGAPSRQKTGTSALKTPGKTDDAKASEKGKSPLKGSSLQRSPSDAGKSSGDEGKKPPSGIGRSTATGSFGFKKPSGVGSSAMITSSGATITSGSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVGLHVSTKTSLQYRSLPRPSKSSTSGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKVAVSDSESVSLSGSPKSSPTSASACGTQGLRQPGSKYPDIASPTFRRLFGAKAGGKPASAPNTEGVKSSSVMSSPSTTLARQGSLESPSSGTGSLGSAGGLSGSSSPLFNKPSDLTADVISLSHSLASSPASVHSFTSGGLVWAANLSSSSAGSKDTPSYQSMTSLHTSSESIDLPLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSESMQLDRNTLPKKGLRYTPSSRQANQEEGKEWLRSHSTGGLQDTGNQSPLVSPSAMSSSATGKYHFSNLVSPTNLSQFNLPGPSMMRSNSIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEEVHGSSLSLVSSTSSLYSTAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSGNDADSKKKKKKNWVNSRGSELRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNGGDCGSASMKPSQSASASPLVWPPKKRQNGPVIYKHRSRICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNVGKPARPPSESASSTSSSSSRQSLGLSLNNLNIAESVTSDILLDDPGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSASLGLSSDCIASYCIGDVTRSHGPEVPELLPCGYLVGDNNVITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLAHKLAEYVTTKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGAELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEMEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRAPWEDPSKWVLDTYPWSSASLPQEGPALLQLRPEDVGYEGCISTKEATTSKHIPQADTEGDPLMNMLMKLQEAANYSGTQSCDSDSTSHHEDILDSSLESTL
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in the regulation of auxin signaling. Acts as a positive regulator of cellular auxin efflux and regulates organ development by enhancing PIN-mediated polar auxin transport. Phosphorylates conserved serine residues in the PIN auxin efflux carriers. Phosphorylation of PIN proteins is required and sufficient for apical-basal PIN polarity that enables directional intercellular auxin fluxes, which mediate differential growth, tissue patterning and organogenesis. Acts as a suppressor of root waving.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSPPFPLLSLHFILLYMYMSPPFSSTHPISQSSTKKRKNQVFSFLRREFDKTKMEELDTLYPPDSDLDLSFTSCASITTTTTDRTLSARSSLARSSLTLSFNDRLSSTSTTNNPSTEIPNLHRRPHRKHDPNWSAIKAATTLSSDGALHLRHLKLHRLVGSGNLGRVFLCRLRDYDHANFALKVIDRDSLTAKKLSHVQTEAEILSSLDHPFLPTLYAHLEVSHYTCLLIDFCPNGDLHSLLRKQPGNRLPVESVRFYAAEVLVALEYLHSLGIVYRDLKPENILIREDGHIMLSDFDLCFKSDVSPKLDFTTRTLERSKRRYSCFSDRLREETVTEFVAEPTGAFSRSCVGTHEYLAPELISGTGHGNGVDWWAFGVLLYELLYGTTPFKGSSKESTLRNIASSKGVKFNVEESRGNEPSGMGEAKDLIERLLVKDPRRRLGCARGATDIKRHPFFAGIKWPLIRTYRPPEVRGLSIKRTKSKLRVSHVTGVTSSSSPRRKCCWWKRLGYLMRIKGSKYNLNSNHNYYCYTNQKVRKCA
The following text describes a protein:
Function:
Has roles in respiratory and lipid metabolism.
Subcellular Localization:
Mitochondrion.
Sequence:
MPNRKVVKFFFDVISPYSYFGFEGITRHRSVWKTPIQMKPFFFAGVVRHTENPGLPLRIPIKEKYMHKDLLFSAQYWGIPFRLPKDYTNMMLNTSSIVPQRILVASQLRDNVLMEDVARGLWHRFYAYGKPIFTKSQVAEVLRDLHVKDVDELVMMSDSAEVKNILRENTDEAIGNGCFGAPWMHITDGHGKVLQTVFGSDRLPQVADFLAEPFKGPMREKKPNA
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLVRYEVQSEHSLANPELYRTVGRDDSEGLLEGVAMAGLVGIVRQLGDMAEFAAEIFQELHDEIMAIGIRGQDLKARVGRLETDLPAVEKTLLSESSQIDFAYSIRSKWRAPLPIDQNCCAQGDLPRFVRNFYDDCRGPPRLFLLDKFDEAGRGACVKRYTDPTFFKLTWAATQLEKAERLRREQEFELQRTNSADEKSLNNEGSKIYRRERLSSALFENLEGFTGDFTPDLRSRRLDRVLELPTEGDLTPDGPLSPEEPRSPERTFQKRPEMPEISEGPVLTPLKISVKDIENLTMGHRISTPNDPKEPSSNEEDASNDDFFVDALTTMGSDPDSEPGSRTRWDAEVQSHFGMESDQEKFLNHSVLKAHVEAHHQPSPEGSDELDQKDGFGRRLGGYKQPESPGAGTGTVRESEDAAENAAGSSGGQPSVEGEESQSVDESIANESITSEESDARNEHASISEKVPEGSLLPLHLEKFPEKRYDEFSNIIPSKLPENLLENLPNGSSGDLLKELSETCPDKLSCIPPKKVPEKVVKNTPIKVPEKPTLESHESISLLEVRKISSKSKEQRASVEVTEQFPGLYNHDPHAVKDDQLALANVEQPITTPRSRRLWAKDNGSQIQTSNILGKADIDHRGLSLRFNGGSELNNLLRAGILGGSGHFHEELSSNSQRALIPEEDHSVRVSEQSGYELILHRRHPSSTGSSPYSHVSSSSAHEDDDGASKSSASSSPKGPNFCALLSPPESPLRVARGLMGSPVGFSSNTHFCSKSLNDPPDIPYLSISPTVSRSLSLNLDLSSSERDELLQNYPSAQQAPQLISSPQRRTNSSSSTSLMINDPAASLAKNLDELESVPVTDPKRTKDNGGLHFESSGNQTSTLSNLASRPRTWVGRSESNVAATLRAIRQAAAVENDQDDDTARLQRKASIHETNKGPVSVDLHKCQFFYTSRERIAGDVGLYRQFWLIGKLSKAFLQAPNVLQYVRNEILNEFDLELNF
The following text describes a protein:
Function:
Subunit gamma, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the central stalk subunit delta, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLSRSSVLILQSQWGQGQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYSRAERELKPARVYGTGSLALYEKAEIKAPEDKKKNLIIGVSSDRGLCGAIHSSVAKTIKNEITSLSNAGKEVMVVGIGDKLRGLLQRTHAGHLLITFKEVGRKPPSFGDASIIASELLNSGYEFDQGSVVFNRFRSVISYKTEEKPFFSLDTVANSESISVYDDIDADVLRNYQEFTLANIIYYTLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALG
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MGVPFDYAPERPEHIDAILNGLDRYNPETTNIFQEYVTLQCEEKTYDCYANLALLKLYQFNPHLTKDETITNILVKSLTVFPSPDFSLALHLLPPHILTPISSSSALPAAGDAPLSEAVQKLAVLNTLLSSANYSQFWSTLDSDDLYADLIADVSGFEELIRIRIASTISQSVREIPSSELENWLGMNGEAFEKFIKEVCGWTIENGSVIVPLNKENEAKGTVVRENVKMEQFSRVIRRAYEQPA