lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis (By similarity).
Subcellular Localization:
Nucleus. Chromosome.
Domain:
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Sequence:
MEQSANARQSTLRSRTQELNTLSVLSKDVSLEDAKKYWKDRQADGKVDWIFEKVLNKLKILWQKIKDGSATNLEYVRAVILVNEAGNLEEDLEEDLKEDTDTIHIDIHKENEVQENTDCSPERKEDTCLNLNTDCGTDVSGSEPECNSTVSPPAAERVYFGNHSCGPSCLSGINSFLFTKGNPLQLPISCDFQRCHLKINSPDDLSHILYKAPCGRSLRDYDEVHSYLTETGCHFLAVDNFSFNNHVRLDSNSSFNQGIVQDCDISNDVESVPVAFSNEIDNTRPSNFIYRKTSWPPGYSLNNFTDIFVKCCNCTDGCLDILTCSCLQLTAQAFTKCMESSLGIGPLGYKHKRLQEPIPTGLYECNVSCKCDRMLCQNRVVQHGLKLRLQVFKTNTKGWGVRCLDDVDKGTFVCIYAGRILIRTADCTVKSTPDDSVACGNEDHEDSTSTCALILSKRKRKTSHSDSEVTVMHTNPYSMRSHGLSVHRLSNTFSPRQARSGEREFSLQPLRRPKTKTSMLQKRRRQLIEEGACTVQNSSEEEGPTPPQSPEQKSSAGTKIQRNENSDETASGYVSEESSSSVISGGHPLEKPISKFKSKLNKTTVYLSTSPEQTCEENLHFLDASKEGNVGRFLNHSCCPNLFVQQVFVDTHQKCFPWVAFFTNSVVKAGTELTWDYSYDIGTAADQEIQCLCGQKTCKNKVV
The following text describes a protein:
Function:
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MLKNIINKKNLFINNQQNIFQIIKRNKMTDSTVDNKGYIVGIYENEEFTPLGQQLNEKTNGHLLKSIKLSDTKGKVGDNLVLYNVTPEVSRVAIVGLGKKENNNSTTYEKNENTRKAIGSGVKALKSKNATHLTIDSNIGDAKQTAEGAFLSNFKFDFKTGTSGKTANSTNESIQVQLSPSPSSEECFKEGKILAESQNFARVLMETPANLLTPTNFVQHVSSQMKELIDSGKVEMIVREEQWVKDQKMGMFWGVAKGSDEPLKFLELHYRGASADGKDSIVYVGKGITFDSGGISIKPSANMGLMKGDMGGAATAVSAMFGVASLGLKVNLITITPLCENMPSGKATKPGDILTAANGKTVEVDNTDAEGRLILGDALHYACSFKPTHIIDIATLTGAIDVALGQHYAGCFTTTDSLWDQLNECGNISGERLWRMPLIPEYRKQMETSKVADLINSAGRSGGACCAAGFLKEFITADQSWSHLDIAGVMSSSEDGPYIRKGMTGKPTRTLIEFAKKNQQ
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Sequence:
MEKVQTERQEIVSEFEHLHQFLKDQEQLLLTQLEEIRKEIESRKDDMVTKLSEELSRLGEVITEMEAKCKQPASEFLQDIRTNMNRCVAQQFQLSEEASKLESRLDDVSRKGEALKKTLKRFQDNMIYAVEKGEMRTLNDKADAMRQWMARCGQTHRKLPALQYVPEVPKELDSTALVLGCDGFTSGRYFWELEVGDGEFWALGVTRDPSNKKGVVDFSPEEGIWAVGLWKGQHWALTSPVTPLSLSKPPKRIRVSLDYVGECVTFTDADTEDPIFTFPPASFNGTRTHPLLWVVGFPAEAVFLRRMGVKYPTALHEMDVLGP
The following text describes a protein:
Function:
May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received.
Subcellular Localization:
Secreted.
Sequence:
MRGQWSVNYRVWFFTVDNDGSFTADASGVDLTLSMRVGRDQNGRPTISSTSSCSANIGDMNARVSGSSLSFLYNILLRFNSNSVRNTFAARICPTVKSAIQSQANSILRNLNVNYALTTTTSIDLALSRPPTTASNQITVFSRGRCFPTNNPSMTIPVTAENLPEFQMTSSHMIRMIVGDYVINTFLYVQWVSGSWDFWFGQDSLAGYVGFNFTTDTMAGFLPGFANFGRNRPLRFFVHPTESPFARTTSENVNITAKFDLVTFVVAENGSLNDALNISIAASLTGNVTVENGNLRGQISALTTKSTVSSSKIGDLPVVLVDLIVNNIAQRLLPSVNNVSMTLQTLPLPSGFGVSNVFVNTVEHGLEIATDMTHAG
The following text describes a protein:
Function:
Required for a complete transcriptional response to osmotic stress.
Subcellular Localization:
Nucleus.
Sequence:
MIDPVTHIVTPSNDEQRQGRSDGGMQLGLEDLHGGGGGLGQQKVSGMAEGTDSIVDVLTNPSSSVNLHSNILSVSTNVEEGQGMQPAAIQGGGTAAGRRFSSVPISDSPVGCGQHGMGTASTQVPSHGSTANLLSMGNPVATNVQVCQRMDEVSARLIVMEETVNKLLGNIDAQQQQIASMRSESMEMLGSLMKEVRELKQQVPVLDDPDNNEKDKFVTDLLNSITNVSSNYLKKVSSRNLQRFKRQRDIMSTSDLPSLGNTQSSSHFMQDLVNPYASTQDFQSFTVLKDKAKEFTLNPTAINKRRRLSAQPLNTLQMSQDQLQQQRGSVQSLISIPTSGQKNANFGPQLQNYLIGLQNIPMSEAEKVSSPTVLKQFQNSTTDPDLKTGRRNPGLDFQIGSGDDENDENDGASGEDEDGYLEDDEGYRSQSQRTMSSEDDEQFTGGNQGEDEAGPRAAGRNPKSLPSSIVRRFANSGSQVSVSGTPETERLVLKNNDKYDKNTMPAPNTKPRAVLASNPEDTLTDVQYTMVKAPDSVRAIWDEYTIGVGGKPSIRQLEQTYGNKWRTKRNKKTFARRKRIYKFILNGVRNGKSESEMIDILESRRVYRTEDNELKKRTIGWLQQSLSGI
The following text describes a protein:
Function:
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSPHRNDPFSDQPNPDLGRYHLSDNDDSFTGQPPVDNHHYANFIPSQSHSHSGESEYELSTPTGRYEAPITFGDQEDEEGIPLKEAPFDSHLGGFRPEAGGLASDPSKPDFDPVANFGFPVPNFSGSSQENTFSSASNTNLYRSQTTTEAWGKRQRIDPKRAKTIKVKLQHGNFVNEYPVPTAVKTANLAGGYKGESTEFSHMRYSAVTCDPDDFTREAGWTLRTENYGRRTELLVAITYYNEDKILVARTLHGVMLNLRDMCKAKWSEFRHMANKSETATEAWKMISVVLVFDGIEPADKATLDVLATIGLYQDGIMKRQVDGKETQAHVFEYTTLLSVSPKPELIQPHANDPANLVPVQMTLVLKQKNAKKINSHRWLFNAVAAHLEPEVCILIDAGTKPGTRSLYYLWEAFHHNPHMGGACGEIHAMLSRGKKLINPLVAAQNFEYKMSNILDKPLESSFGYVSVLPGAFSAYRYRAILGRPLQQYFHGDHSLSERLGKKGIQGMGIFKKNMFLAEDRILCFELVAKAKSRWVLGYVKPAKGETDVPEQAAELIGQRRRWLNGSFAAGIYSLAHFSRMYSSSHGIVRMFFLHVQAFYTTAGLIMSWFALGNWFTTFSAIIDIIAENWRDPFLAAGISNYTLTPPPSPPNSSEGAQALVAWKIKECWSGTVFDNTEHLKDNSVPSKHDYLGVANWILKIIYVILALGNRPKGEKAAYLVSFIIFGIFAAYLLSMTLILTIKAFCPLTAQIEAASGGDVLLVFMGSTYGPIFAGIAGTFGIYIISSFLYMDPWHILHSMIPFLLVAVSFTNILNVYAFCNLHDVSWGTKGSDKAEALPSISSKKVSKESGEQIVEDIHRNQHDLDAQFQQTVIRAVQPFKVSEEPEVPTEDDQNKTFRTRFISVWLIMNFILAIAMLRLSSTNRTKYFQALLWSNFGFAFVKFCGFIYYMFGASFFRLARLCARARR
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MEEKLTQAIESISLSEADSETKVLIDISNQVISLKMQYEKEMISIRKQIETLKAKAAQEKQQAENQAENDHFYSKAIENLQKKYQELEQSSRSANLRNDNDATKLNQLIQQKESTSKDRKTVETQVMEKTKCKQFFDLYTNISGIEWNYHCSADQIKGVIMYENDCKPFALNVSENTDFEMTNKLWQLL
The following text describes a protein:
Function:
Helps membrane protein BCG_1471c (P55) transport triacylglycerides (TAG) across the inner cell membrane into the periplasm and probably ultimately to the outer membrane (By similarity). Binds TAG in its hydrophobic cavity and transfers it between lipid bilayers (By similarity). TAG probably regulates lipid metabolism and growth regulation and plays a structural role in the outer membrane (By similarity). Binds di- and triacylated phosphatidyl-myo-inositol mannosides (PIMs), and glycolipid lipoglycan modulins lipoarabinomannan (LAM) and lipomannan (LM), facilitating their recognition by TLR2. Required for activity of drug efflux transporter BCG_1471c. Required, probably with BCG_1471c, for normal surface localization of LAM; Constitutes a host TLR2 agonist (toll-like receptor) (By similarity). In vitro binds to human CD209 (DC-SIGN) and CD209-like antigen (CLEC4M) and may help mediate adherence to host cells.
Miscellaneous:
MISCELLANEOUS: Bacterial LAM blocks host cell phagosome-lysosome fusion and is one way in which Mycobacteria evade the host immune system; MISCELLANEOUS: Triacylglycerides accumulate in lipid droplets in the cytoplasm of M.tuberculosis stationary phase and dormant bacteria, and are used as an energy source during starvation.
Subcellular Localization:
Cell inner membrane; Lipid-anchor; Periplasmic side. Secreted, cell wall. Secreted. Note=Present in extracytoplasmic vesicles.
Domain:
Forms a U-shaped beta-half-barrel with a small hydrophobic cavity able to hold a triacylated lipid or triacylglyceride (By similarity). A flexible lid region may move to accommodate different TAG molecules (By similarity).
Sequence:
MRTPRRHCRRIAVLAAVSIAATVVAGCSSGSKPSGGPLPDAKPLVEEATAQTKALKSAHMVLTVNGKIPGLSLKTLSGDLTTNPTAATGNVKLTLGGSDIDADFVVFDGILYATLTPNQWSDFGPAADIYDPAQVLNPDTGLANVLANFADAKAEGRDTINGQNTIRISGKVSAQAVNQIAPPFNATQPVPATVWIQETGDHQLAQAQLDRGSGNSVQMTLSKWGEKVQVTKPPVS
The following text describes a protein:
Function:
Required for efficient biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPPRPRKRVRRRRVSEKFDDSSDSSSSSSDSGQSNQSTPKNPNSVNKSSSDSHGSSSESESTDSSSSSSSSSSGSSINRPTAKRGRLAKKQNLQARALQPQDGGDPTNPQMMRRSPSPVEQSPPPPLPSSFFDPDLALPYLDSSPDFSLPAGFESKAPTRQVDGLLQSTRQQLEQDEERFRAWYMATIVDRFPNELDLLRSSDNNPQKTQSNLDLLVAALGSGVDIFDDNIILSSTSSSSPTVAANKAALDDHQLVLQSLDLAKQTLHLDPSICPQPVASPQSHEDVEMSDGADS
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The tim-8-tim-13 complex mediates the import of some proteins while the predominant tim-9/tin-9.1-tim-10/tin-10 70 kDa complex mediates the import of much more proteins (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of tin-13/tim-13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).
Sequence:
MDQLLDVETLKKLSPEQQEQVISGVKQQAALANAQNLVTDISEKCTNKCITAPGSSLASGEKQCLQRCMDRFMESWNLVSQTLQKRLQEEMASSGGMGGGFGQGPSFS
The following text describes a protein:
Function:
Required for efficient ubiquinone (coenzyme Q) biosynthesis under aerobic conditions. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both. Dispensable for ubiquinone biosynthesis under anaerobiosis. Required for proliferation in macrophages and virulence in mice. Significantly contributes to colonization and invasion as well as host inflammation and innate immunity after infection. In vitro, has membrane fusogenic activity at acidic pH.
Subcellular Localization:
Cytoplasm. Note=Is both soluble and membrane associated inside the cell.
Sequence:
MASTYRTTIRANTYQFRETTMIDPKKIEQIARQVHESMPKGIREFGEDIEKKIRQTLQSQLTRLDLVSREEFDVQTQVLLRTREKLALLEQRLSELEARDKPEEVKPAPAIPPVDPQQE
The following text describes a protein:
Function:
Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase. Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop. May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Note=Localizes in the nucleus during early S-phase of the cell cycle.
Domain:
Contains four of the five characteristic MBL-fold metal-binding motifs, with two waters completing metal coordination.
Sequence:
MSGLVRTEPLPGETPLLVPGDPYSVVVLLQGYAEPEGVGDAVRADGSVTLVLPQAWGPASSHREPQPYEAKTALEEAARGPILVDTAGPWAREALLGALAGQGVAPGDVTLVVGTHGHSDHIGNLGLFPGAALLVSHDFCLPGGRYLPHGLGEERPLRLGPGLEVWATPGHGGQRDVSVLVAGTALGTVMVVGDVFERDGDEGSWQALSEDPVAQKHSRKRILGTADVVVPGHGAPFRVIREASAPETEPARSRDGEEPTVHG
The following text describes a protein:
Function:
Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'. Inhibits MTF-1 transcription factor activity.
Subcellular Localization:
Nucleus.
Sequence:
MEAKTDAPISPAPTTNPPAEAGKEPNASSNAQANPTAAPGAPPSGAIAVGQSTNPVAQQQQQPAVAKKPSSETNNMPTRQYLDQTVAPVLLHGMQALARERPTDPIQFLASYLLKHSNGCDENNASAAAVDNNS
The following text describes a protein:
Function:
May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway.
Sequence:
MLKKRSRSKQALMAETNQSQNQKQSKTTPFPRLFTAFSSFKSFTENDAVASPTSILDTKPFSVLKNPFGSDNPKTQEPETRLKLEPKRIGLAIVDSLIQDETPEPGPRSGTILFGSQLRIRVPDSPISSSDFGIKTRNSQPETKKPGSESGLGSPRIISGYFPASDMELSEDYTCVTCHGPNPRTIHIFDNCIVESQPGVVFFRSSDPVNESDSDYSPPDSFLSCCCNCKKSLGPRDDIFMYRGDRAFCSSECRSIEMMMSEENDTK
The following text describes a protein:
Function:
Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide. Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses; [Isoform AGX1]: Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P); [Isoform AGX1]: Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P).
Subcellular Localization:
Cytoplasm, cytosol. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail.
Sequence:
MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEGFNQSSHQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAYPKGMYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMESTKEFFTKHKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPYVDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQCEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI
The following text describes a protein:
Function:
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
Subcellular Localization:
Lysosome.
Sequence:
MFRVPLCMLLPLLALLQLLGAAHSFYNVSQRTFELDYKRDRFLKDGQPFRYISGSIHYFRIPRFYWEDRLLKMKMAGLDAIQTYVPWNFHEPQPGQYDFSGDRDVEHFIQLAHQLGLLVILRPGPYICAEWDMGGLPAWLLEKESIVLRSSDPDYLAAVDKWLAVLLPKMKRLLYQNGGPIITVQVENEYGSYFACDYNYLRFLEHRFRYHLGNDIILFTTDGAAEKLLKCGTLQDLYATVDFGTTGNITRAFLIQRNFEPKGPLINSEFYTGWLDHWGQPHSKVNTKKLVASLYNLLAYGASVNLYMFIGGTNFAYWNGANMPYAPQPTSYDYDAPLSEAGDLTEKYFAVRDVIRKFKEVPEGPIPPSTPKFAYGKVALRKFKTVTEALGILCPNGPVKSLYPLTFTQVKQYFGYVLYRTTLPQDCSNPKPIFSSPINGVRDRAYVSVDGVPQGILDRNRMNVLNIRGKAGATLDILVENMGRVNYGNSIKDFKGLISNMTLNFTVLTNWTMFPLDTEALARSHLGNWEAADEGHLDGHSTLRSSNFTLPTFYVGNFSIPSGIPDLPQDTFIQFPGWAKGQVWINGFNLGRYWPTKGPQMTLFVPRNILTTSAPNNITVLELESSPCSNGTLELCTVEFVDTPVIG
The following text describes a protein:
Function:
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSIMSYNGGAVMAMRGKECVAIASDRRFGIQAQLVTTDFQKIFPMGERLYIGLAGLATDVQTVSQRLKFRLNLYELKEGRQIKPRTFMSMVSNLLYERRFGPYYIEPVIAGLDPKTFEPFICSLDLIGCPMVTEDFVVSGTCSEQMYGMCESLWEPDMKPEDLFETISQAMLNAVDRDAVSGMGVVVHVIEKDKITTRTLKARMD
The following text describes a protein:
Function:
Probably involved in guanidinium transport. In vitro, confers resistance to a broad range of toxic compounds such as cationic dyes, neutral and anionic antimicrobials.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASFSLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLKILS
The following text describes a protein:
Function:
Catalyzes the release of fatty acids from lysophospholipids (By similarity). Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection (By similarity).
Subcellular Localization:
Secreted. Secreted, cell wall.
Sequence:
MQLSVLIASVLAAGAAVDAASYTPQNVSCPDNANFIRNAADGLSPAEKEWLKKRDPITRDALQTFLRRAFANVSTEITSALFNDTENVPKLGIAVAGGGYRAMFVGAGAFAAMDNRTDGANEHGLGGLLQAATYMAGLSGGNWLTGTLAYNNFTSVQQILEEGDKADAIWNITNSFLNPYDKDFSKTLARWTAIGSQVQGKRDAGFNVTITDLWSRALAYGWFPTLPNAGAGLTWSSLRDNEIFMNGEMPMPISVADGRYPGTTVINLNATVFEMTPFEIGSWDPSLNAFSDIKYLGTQVTDGKPETERCINGFDDASFIMGTSSSLFNEFTMSNDSAVAYTYLNTLSSTLVKGIDKENNDIAMYAPNPFKGSKYVDSNYTTSIVDSDSLFLVDGGEDLQGIPFVPLLKQERDLDIIFAIDVDTETSDNYPAGGPMMKTYERQFSKQGKGMAFPYVPDMTTFVNLGLGGKPSFYGCDANNLTDLEYIPPLIVYIPNSYHSFESNVSTFKLNYNYSERVGMIRNAFEATTRNNLTEDADYVTCVGCAIIRRKQQSLNLTLPDICDKCFTNYCWNGTIDNTPTKLLTPNNQDPAAISSAIAAVTDDSPIGALLNTGSGTKSNSSSKTNSTLVTSSRATSTGTLISNSSSNSTVSSTAARSSTSSTAKKNAGSVLKLEFSKSASVMVAIAAAAVASLI
The following text describes a protein:
Function:
It is thought to provide protection for the cytoplasm during the desiccation stage of embryo development.
Sequence:
MASKQLSREELDEKAKQGETVVPGGTGGHSLEAQEHLAEGRSKGGQTRKEQLGHEGYQEIGHKGGEARKEQLGHEGYQEMGHKGGEARKEQLGHEGYQEMGHKGGEARKEQLGHEGYKEMGRKGGLSTMEKSGGERAEEEGIEIDESKFTNK
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Nucleus.
Sequence:
MSSTSSTNRGAPVIFQFTPTHLVVGAIGQVGGPNVIPYDGYTLQWPTQVEGDTEEPGANLGSLLSFLHKTIRHAFSSVLLLDSSKHKAIICESVFPLSDPIKRVLRLVFTGYEQIPQSSRDGRQSRDGRHSRHSNDGRQSRDTHTRESERFSREGVHVARKAGFLNCPGIAFSPTPLCLTLSARSDVALVIDVSSVEITIVPVYDSRVMSSHVKFRKAAPLDQLFEHSADSHDDDDEVPLHTIIYKLVKSLDIDLQPPLYENLLFSGLKIEGLEAKTVEKLDELGTKCQVIQPMDLWTATTVFYQSTGNPERLRRVRLIGDLVVDLDTAAVKECTRFLELCENEDFNGVMLEMSGKVLSTLRGGSGISGGRDGGSSSEVGAVGFSESGDLLFSLGEKLDHALGHIVEGAELLEGLNGGSIEIIHVLEGLETGEEGEDAAEDSVIGDDGTKEDTGLQAGLNITKADSAKATHAAPSETTSQALTLEIIGDLPFAEIKPSETVLFVCKLNPVTEAEDLELIFSRFGEITGCQIVKDPVTGSSLQYGFIEYTTREDCERAYLKMEGVLIDDHRIHVDFSQSVRKMQQRKQGGGGREWRDYDPEERRSGRDSRSDRDSRHRRSDDKRSVDRGADRQSDRRSHRSDRDSRDSRSSRTNRSSRSDRDYRESRDNSDSHDSRRSHRDSRDSHRSGRDRDRDRSPGRSRRPDRDRRDRDRDYDRDRDRDERDSRDRRDRRDRREGHERESDKRSHRPLRSDKDRSERRSRH
The following text describes a protein:
Function:
Involved in transformation (genetic competence for DNA uptake). Required for DNA uptake but not for DNA binding to cells. DNA uptake is energy dependent, this protein may provide the driving force for DNA uptake (Probable). Does not have helicase activity, translocates on single-stranded (ss)DNA in a 5'-3' direction in an ATP-dependent manner, but does not unwind double-stranded (ds)DNA (By similarity). ATP hydrolysis causes the release of ssDNA from ComFA. A ssDNA-stimulated ATPase; dsDNA does not stimulate ATPase. ATP hydrolysis causes the release of ssDNA from ComFA. Binds ssDNA but only very poorly to dsDNA in the absence of ATP. Binding to ssDNA does not require free DNA ends (By similarity).
Subcellular Localization:
Cytoplasm. Note=Localizes mostly to the cell poles during the development of competence. Colocalizes with ComGA. During competence a number of proteins (at least CoiA, ComFA, ComGA, DprA, RecA and SsbB) are thought to colocalize at the cell pole, in a disruption of comEC, ComFA no longer accumulates. During development of competence ComGA and presumably ComFA colocalize in discrete foci which accumulate at the cell poles and then delocalize without the overall levels of proteins decreasing, these processes are coincident with the timing of transformability and the site of DNA uptake.
Sequence:
MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGYITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSWKEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGIESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTHQLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKALNGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFLFVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVTVPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIKEMNELAAKVECTD
The following text describes a protein:
Function:
NAD-dependent deacetylase (By similarity). Involved in metabolism, apoptosis, response to oxidative stress, response to DNA damage, and determination of lifespan. Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16/Forkhead box protein O in the Insulin/IGF-1-like signaling (IIS) mediated pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticulum (ER). Functions upstream of transcriptional coregulator hcf-1, perhaps acting independently of the IIS mediated pathway, to modulate lifespan and oxidative stress response. Acts upstream of the nicotinic acid metabolism pathway, which may be linked to the regulation of longevity. Plays a role in ascaroside-mediated longevity and stress resistance.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Translocates from the nucleus to the cytoplasm during apoptosis.
Sequence:
MSRDSGNDSEVAVTHGEVQEITEENPEIGSMHITQETDISDAPETNTDSSRQRTESTTSVSSESWQNNDEMMSNLRRAQRLLDDGATPLQIIQQIFPDFNASRIATMSENAHFAILSDLLERAPVRQKLTNYNSLADAVELFKTKKHILVLTGAGVSVSCGIPDFRSKDGIYARLRSEFPDLPDPTAMFDIRYFRENPAPFYNFAREIFPGQFVPSVSHRFIKELETSGRLLRNYTQNIDTLEHQTGIKRVVECHGSFSKCTCTRCGQKYDGNEIREEVLAMRVAHCKRCEGVIKPNIVFFGEDLGREFHQHVTEDKHKVDLIVVIGSSLKVRPVALIPHCVDKNVPQILINRESLPHYNADIELLGNCDDIIRDICFSLGGSFTELITSYDSIMEQQGKTKSQKPSQNKRQLISQEDFLNICMKEKRNDDSSDEPTLKKPRMSVADDSMDSEKNNFQEIQKHKSEDDDDTRNSDDILKKIKHPRLLSITEMLHDNKCVAISAHQTVFPGAECSFDLETLKLVRDVHHETHCESSCGSSCSSNADSEANQLSRAQSLDDFVLSDEDRKNTIHLDLQRADSCDGDFQYELSETIDPETFSHLCEEMRI
The following text describes a protein:
Function:
May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function. May play a role in lysosomal ion flux and osmoregulation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Lysosome membrane.
Sequence:
MASENSPLLAYRLLGEEGVAFPANGTGGPGGASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATNGAVRGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVEAILDVFGADAAGSSGLRVLPQGYGWSLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLVSFVAVGPRDIPLTPRPGPNGSSLPPQVGHFTGFNSSTLKANLGAGYAKDYTTGAVMTFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTITAVAYTFFIYILLFFLSSFTCDRTLLQEDYGFFRAISLWPPLVLIGIYATSLSASMSSLIGASRILHALAQDDLFGVILSPAKVVSRGGNPWGAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLSALLTARVGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKKGGLYVLGHVTLGDLDSLPSDPVQPLYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAAPQDHFLTDPAFSEPADATQEGGSPALSTLFPPPRAPGSPRALSPQDYVATVADALKMNKNVVLARACGALPPERLSRGSGGTSQPHHVDVWPLNLLRPRGGPGYVDVCGLFLLQMATILGMVPAWHTARLRIFLCLGPREAPGAAEGRLRALLSQLRIRAEVQEVVWGEGAGSEEPEEEEEGDFVNGRRGDAEAEALARSANALVRAQQGRGRGGGPGGPEGGDGEEGPTTALTFLYLPRPPADPSRYPRYLALLEILSHDLGPTLLIHGITPVTCTDL