lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.
Subcellular Localization:
Nucleus speckle.
Sequence:
MYPSWNQQQPYGSQQDMHPYQHQSQMNTYQQQLYWQHYYALQQNQQSGTQPPASSAATPGGQNPPLPSETGEKPPLPSEPPPQDNPPLPGNATESGTASSAEAAKMTQLAEQARQWQAMKQWQEYQYSMMQQTMQQQQAWIVQQQQNMQQQHAMQQMTPDQMDNELERQAEQFQKQYEQWQKQFEDWKEQHKNHPNQEQFLQYEQQWKQWQKQMEQMWAAQKEQLQRAKDMAQQQQQQQPVSSGTAFSQAGSMSTAPYSQAGTMSGPGFSQSGPPYSTQTGTMSNQTGTMSNQTGSIAGPPHSQTPGTSMQNTPYSQTGPMQEPGHHQGFGPRGPRFDGPRGPRFDGPRGPRFGGPRGPGYDSSSGPQFRGRGPMMEQNRARFGPRGGQQQPGMRGPRPLMDDYGPAGRGGMYGQRQDQQTGPGGGEQGGGPMGRGRGFSQEFGRGMGRGGGEVQGTGQLSGLGSKEDLATGDFTESQDATQGAEMGQEYGDSAGQKPGMGRGFGGQGQGPGMGQGFGGQGQGPGMGRGFGGQGHGPGMGRGFGGPGQGQGMGRGMSGPGQGPDKGDGFGGPGQRPGMGRGFGGPNQGPGMGRGFGNNLGPSQGPGMEGGFPRGQGSGQFGPGRGRGRGQEPGLQQGRGPGMGRGFQPDSQGMGRGFGQQQGDFGQGRGRGFNMSEQSEEDAKRPSLLGDSPGTGQAIEGQETGEEEGQESSQVTKESLGMDEDFRKNQGIAIGPRGQSPMQRPQGPGFGPAEGQRFGPRGRGFNQMEGGPRFGPRGGGFNQAEGQRFGPRGRGLDQSEGPRFGPRGRGFDQTEGPRFGPRGRGFDQSEGPRFGPRGQNVGQRFGQRGRGFNQAEGTRYGPRGGLDQFGRPRFDPRSQEGFGPRSLMESQGPRGMGPNQGPRPVGPGSAGQAEEVKPAPAQEGPKDVDMRTSRGKVDEPKALTDKGPEKKGPDVKTEQGKKPEAPKQAGAASTAQPSQAPAKPPAPSPAKPTDKRAPEPDKSGSQPGMAKTSTTPSSSSQAPTASTSTVSGAVQTPPARGKAKTSASETSEKGMEGKEEEKTEDGTPKFSQREADLLVKAAKDLKMIRQAQEQLRRLEEISALGKVTTVMSKHLRPGASRGMESTDSKGPGHLSTTEGGISRGKDAARAGELGRGPEASLGQEPSRGPENLHEAAGTEQDMDLESERASHSSRGSNQGRDLGGLEGARGGLGGPDEPRRGRGGQEEARMGYEERYRSYRGGEEADYGEQPYRGYQEDYYEEESVRDPYGRDPYRGREQAYGEDRDFGDRYEDPYYSRREEYREDYRRETPYYEDDRPGEKYRREEPLRRAEEYGWTDDYRRAEVYGRGEDYPRGRLERDREPQPPGVDDAYLYERHAYSDDQYMLDRPAVREDSQSRGLAGRVVESIDYGHGEKAPGKAFSHLLTTSPAEAASKSSFSHLLSASAGTAPEAPATSQGGLFARSGMVEEIDYGHGQHAPLGREVGTDTFLRERGVLVGRAEEDRLSGRGLEGVPRERSVSVSIQSRERSRDRTSLEEGSRRGRSIEDVRLPPSREREVSRERDRERSWDRDRERSRDRERDFVREGDLPSRARERDLPRDDRDRARGLDDRYDRSRRREADDLDRYRLGRERDADRDRLYPETSSLYRDYDRDRHDRERDRDRFAPPLPPTSRYERDPYTREREHYYDRPPYERGAYGGGPPPPGPYDVRDPYAAPPGPPPQPPPEEPKPETVSAEDILKEPGRKTRPKQLVAILRGPPGCGKTHVARLIKEKETEAGASAPRIFSLDDYFMTEVEKTEKDPETGRRVKTKVLEYEYEPEMEETYRASMLKAFKKNLDNGFFPFMIVDAVNDKVKHFQPFWSAAKSKGFEVYLVELTAEPHACARKNTHKRTLKDITKILDRWESAPRHMMRMDVRMLLQEAAITEVEMEDFDDSQDSSQGDPQQSAGGKGPEEEEDVEEGQVFYAKSRWEMDTSEHQLDKLDGIRLHKKSAEDRRQSMSEFLSLVDEYNRNVQPGKKQVRWADIEERMTQEKKRAMGFVVGQTQEDWERMTGGDSYAERALKRTKFF
The following text describes a protein:
Function:
Required to generate and maintain the structure of the tubular endoplasmic reticulum network and the vacuole. Induces high curvature in membranes and causes membrane tubule formation. Involved in membrane/vesicle trafficking (By similarity). Required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Enriched at the cell equator during mitosis.
Domain:
The short lumenal loops between transmembrane domains 1 and 2 and between transmembrane domains 3 and 4 may impart a wedge-like configuration, thus deforming membranes.
Sequence:
MSFQVRVKQNMQDLDNRLAAFPQLNSLEKNFGVSKLYVFLTAAGIYALFLFLNWGGFLLTNLLAFAMPAFFSINAIETTNKADDTQWLTYYLVTSFLNVIEYWSQLILYYVPVYWLLKAIFLIWLALPKFNGATIIYRHLIRPYITPHVIRICKSVSRQNAAPAPTASSFAHTTATDIPPSI
The following text describes a protein:
Function:
Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules. Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity.
Sequence:
MSHFKFIDIVINLTDPMFRGIYRGIQKAVEIGVKKFMITGGNLQDSKDALHLAQTNHMFFSTAGCHPTRCGKFEKNNPDLYLKELLNLDENNKGKVVAIGECGLDFDRLQFCPKDTQLKYCEKQFELSEQTKLPMFLHCRNSHGVVHSFDGFNSCSLKTETNLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIKTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLESANTLYNNTIKVFFPGI
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDILSEMRTKGSSQTPGEPGQPHPSRVSALSADISSSHQSRLLQQLDEQRRQELFCDCSVLVEGRVFKAHRNVLFASSGYFRMLLSQGAQDCGQPVSASFEVFSQDTFTVILDFMYSGKLDLTSTNVIEVMSAASYLQMTDVIGYCKSFIKSSLDISAKEEDDHYLSLSENASRSGGVREPQDYSSSNAGAMLKSPSSSQPASWHIYNSPEVDYHKETKSEPEPAKRGSSPSEQPSRRMGRRALQIADPELHASPGGYQFSLGPEGGAGETGKKKDWSIQPAATRSSSELKGAPSRPKAEKADELYNTLPTIVGVVGLFNRDECPTMRFKCPFCTHTVKRKADLKRHLRCHTGERPYPCEACSKRFTRLEHLRSHFQTIHQARKLICRKCKRQVTELSGRVVCEGTRRYRLCNECLLESGCDSVVFDSSDPAGGVMGPYFGEEEGDKGWPMTDEDDLAEDSGADLIIQEVEDSDEELEQKETKPVVS
The following text describes a protein:
Function:
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTPEREQPRRKHSRRSLHRSGSGSDHKEEKASLSFETSESSQEAKSPKVELHSHSDVPFQMLDSNSGLSSEKISYNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRSELRLKHVDMGLPEVPPPCGPSTSPSSTSLEAGPSSPPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ
The following text describes a protein:
Function:
Gasdermin-like protein involved in heterokaryon incompatibility, a process that ensures that during spontaneous vegetative cell fusion, only compatible cells from the same colony survive (non-self-recognition). In N.crassa, the rcd-1 locus exists as 2 incompatible alleles, rcd-1-1 (AC Q7SBA0) and rcd-1-2 (this entry). During the allorecognition process, forms a heterooligomer with rcd-1-1, thereby forming a functional gasdermin-like complex that binds to membranes and forms pores, triggering cell death. Binds negatively charged phospholipids, such as cardiolipin and phosphatidylserine. Also binds to phosphoinositides, preferentially to phosphatidylinositol-3-phosphate (PtdIns-3-P), PtdIns-5-P and PtdIns-3,5-P2.
Subcellular Localization:
Cytoplasm. Cell membrane; Multi-pass membrane protein. Note=Cytoplasmic in the absence of rcd-1-1. Forms a gasdermin-like pore that associates with the cell membrane in the presence of rcd-1-1.
Sequence:
MDNEEWFPLKQTHYPPPTIPSMKTGHPTGPISIGHIIPDLRHLDNVINCKGFEPFPPNMDVFTAHYEQCHFGDHLNSEFVVQAKAAAPIKNIVPGVDVTGSAGLHHTNITSDRWEYDSVVEYAVYPTRQYIDRLLESKEVKQYIQKSKKLLGGWCVYMVTGIMVARGGGRNVVSEEKGAGVFGNVGFQVPGIGEXAPEVGWDTKTKTKVNAHHTTDFVCAIRLVKIAKSGLRSSWTMKKVTREF
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MAGVQKRKRDLEDQDDNGSEEDDIAFDIANEIALNDSESDANDSDSEVEADYGPNDVQDVIEYSSDEEEGVNNKKKAENKDIKKKKNSKKEIAAFPMLEMSDDENNASGKTQTGDDEDDVNEYFSTNNLEKTKHKKGSFPSFGLSKIVLNNIKRKGFRQPTPIQRKTIPLILQSRDIVGMARTGSGKTAAFILPMVEKLKSHSGKIGARAVILSPSRELAMQTFNVFKDFARGTELRSVLLTGGDSLEEQFGMMMTNPDVIIATPGRFLHLKVEMNLDLKSVEYVVFDEADRLFEMGFQEQLNELLASLPTTRQTLLFSATLPNSLVDFVKAGLVNPVLVRLDAETKVSENLEMLFLSSKNADREANLLYILQEIIKIPLATSEQLQKLQNSNNEADSDSDDENDRQKKRRNFKKEKFRKQKMPAANELPSEKATILFVPTRHHVEYISQLLRDCGYLISYIYGTLDQHARKRQLYNFRAGLTSILVVTDVAARGVDIPMLANVINYTLPGSSKIFVHRVGRTARAGNKGWAYSIVAENELPYLLDLELFLGKKILLTPMYDSLVDVMKKRWIDEGKPEYQFQPPKLSYTKRLVLGSCPRLDVEGLGDLYKNLMSSNFDLQLAKKTAMKAEKLYYRTRTSASPESLKRSKEIISSGWDAQNAFFGKNEEKEKLDFLAKLQNRRNKETVFEFTRNPDDEMAVFMKRRRKQLAPIQRKATERRELLEKERMAGLSHSIEDEILKGDDGETGYTVSEDALKEFEDADQLLEAQENENKKKKKPKSFKDPTFFLSHYAPAGDIQDKQLQITNGFANDAAQAAYDLNSDDKVQVHKQTATVKWDKKRKKYVNTQGIDNKKYIIGESGQKIAASFRSGRFDDWSKARNLKPLKVGSRETSIPSNLLEDPSQGPAANGRTVRGKFKHKQMKAPKMPDKHRDNYYSQKKKVEKALQSGISVKGYNNAPGLRSELKSTEQIRKDRIIAEKKRAKNARPSKKRKF
The following text describes a protein:
Function:
May play a role in RNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MDAIRAQLDEFLGKDRNLLPKDRIKVENDFNDPDICKFFLCGLCPHELFTNANIRDLGPCSKLHDENCVKQYQNNKDKDKYDYEREWVRVIEGLISDNDKKIKRNKERLLQNPNGDANHHGGPIQQQSISQLDDEEGGLLPDKEQNSKITELDLKIQELLKKAEELGEEGQITEAQALMTEADELKNQKVELEKIEQEKNENKRMSVCEICGALLFVGDKEKRSISHLEGKKHIGFQKIREVMEEYYKSGRRANLGRTDFYNAPPPPRDSYRDDRRSSSSSYHDIDGRRDHRYGGGSRDYGGSDRRGGGNYNNGRGSSRDNYNNINNSRDYRNDHGKDYDRKRERDYYNDDDRRKRDRNY
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MTDAMIQEELASYLSDADRKTESPDTSFINSPSQTIPTENSSITNLKGFYNADIGNQLNQDALHSILENLEQSRCTRPVNLQHSLSSSSMNEEEVMTKPEFINPVLLSSATLPKLPSSLSPTTSAQHDSEADGTEVVLPSNNSNLQKAHNNLFMDSSLGNDYDNEVVDFFDVFGERDSLILNDDDADDEQDHDHDQDYDQDQDNFDDSAILSGSRRVSKLLSPTSLQTDRRASLTQTVELASSNPQTKHANAHEEIDANASDISKTLNEYSLDFHSASKLTKYRNRRQSVHGPVGSGVTKRKPSLESPLTSPTRTLQALSNANNQYRLTNNAGALNSMLLWEDAVLSDDDDLNEGEDRRNMFIASPASSGLFLNGNEDAALEVVEPSLNVSPVFNPKSLSILDAKNIELSSSKSSTTPVKEFATPMSSRTSVGSLAPSIASNSTTSIRRRRRSAVTPMSSRSSQSLSRRNKSVSVELPDGAKPFQCADCDKAFRRSEHLKRHVRSVHSTERPFPCMFCEKKFSRSDNLSQHLKTHKRHGDF
The following text describes a protein:
Function:
Required for mitochondrial complex III formation.
Subcellular Localization:
Mitochondrion.
Sequence:
MLVRNICKFTQVMGRFRVVVNPRDYCHLAPLKRSRYHQRSEFGCRPLCSNAAGYEVSWAAPPASGSSGGMFWAFSAAFTLNLFGGADEKEETPEEKLIKTIKRSILCIQREQYDKAEQMLHLALRMAQDIQSKDGITYVFDLMANLAMEREQFKKAEKIFTDVMKRLFAEGHTEESPKILHISSKIAHMSQLQGDLEKSFQGFTWTLQQLAKLLEKMPDDKDILELYGLTKNWFGQLLMKQGKYLEAKNLFKEAFDTLINVYGAVNDASVTILNNISVAYVNLEKYAEARETLLEAMELTKELKDATQEGILQANLGLVYLREGLMSQAENACRLAWKLGKQHQNPDAVEQAEYCLNEIKTTLNGEKRQ
The following text describes a protein:
Function:
Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.
Sequence:
MMQPRPSQSQYCQASLAASFAGAGWARSKAIWPVPTRPALVLAAAHSRRKKQQSGGTSLHKATTTAGDTSSSRLEARSLAAQEHRVYVGGKLLLQSFLDSPSNQLRLSFQLVSATVAGGDGRGVMGGEAVLESILGAREETELDVKLAWHAALGKPGAVVVTNHSDFPVYLKLLSCPAAAGSAGIAVCFACNGWVYPVGKHPHRLFFTNDAYVKEDTPSPLLAYREDELAVLRGEEGAGEQPFQEWDRVYDYALYNDLANPDLRKDLARPVLGGSREYPYPRRTKTARPPTRTDPLTETRVSLDKQIYVPCDERVGTAAIAAPSPPNLGGHFKSIAEIYGLVGLDDVGRLAKAKQIINSGAATPKLPVPQVISVNPMSWRRDEEYARQMLAGTNPVCIKRVTKFPLTSELDRTVYGDQDSKITKDHIQRNMSGLTVQQAVEDGRLFVVDHHDWVMPYLKRINELPGEEEKGEISQRKAYAARTILFLNDDSTLRPLAIELSSPHPDDERLGAVSTVYTPPDASEETLSADKFTAWDLAKAHAAVNDTSKNNFVIHWLNVHATMEPLIIATNRQLSVLHPIHKLLKPHFRNTLHVNAVARQIVLGSGDKRKNGDIFRGIQEVTYLASKYALEMSSKAYKNWNFTELALPADLIKRGVAKGDPKNPEKVDLLIKDYPYAVDGLEIWTAIKKWVTDYCTIYYTNDSAVTGDSELQAWWREVRHVGHGDLQGAQWWPAMDRLADLVETCTTIIWLGSAFHAAVGLGQYGYQGFVPNSPTLASRPMPEVGAAVTEAEFLGSITPRKETLALMGMSAKSLARTGEVFLGQRPDSELWTSERRAGEALTRFQARLEVVADRIQRRNADRTLKNRAGPVEVPYTLLTPTRKPGPVIRGIPNSITN
The following text describes a protein:
Function:
Essential protease involved in epiderm development. Required for aleurone cell development in the endosperm probably by maintaining and restricting the aleurone and embryonic epidermal L1 cell-layer fates as well as meristems organization. Involved in the maintenance of adaxial/abaxial axis information in developing leaves, probably by regulating cell proliferation and expansion. Does not need calcium ions to be active.
Miscellaneous:
MISCELLANEOUS: Although homology to other calpains is high within the protease domain, the lack of calcium-binding sites suggests that this protein is a protease that may not be activated by calcium ions.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm. Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.
Domain:
The transmembrane regions are not required for calpain activity but may play regulatory roles.
Sequence:
MEGEGHHGVVLACSICGFLFAVLSPFSFWVLWAVNWRPWRLYSWIYARKWPTYVQGPQLSTLCSLLTLCAWLVVISPIAVLLVWGSVLIALMERNIIGLAVIMAGVALLLSFYSIMLWWRTQWQSSEAVAYLLLLAVCLLCAYDFCAIYVTAGASASELNSPSGFFFGVSVISLAINMLFICKILFNVSGFDVDEYVRRSYKFAYSDCVEVAPVSCSPEPPDPSELYMTKSSRVKHLGLLYISSLLVLVGYSILYGLTSKEARWLGALTSVAVVILDWNLGLCSFRFELLKSRMIVLFVAGTSRAFLVSFGVHYWYLGHCISYAFVASVLLSAAVSSWLSISNPSVARIDALRSTVIKLREGFRRKGQNSSSNSSEGCGSSVKRSSGSVEAGQNGNAMDSMYRSNSQSDGVNWSSIPFDRSNSCQEGRSSDKNIDSARASLAHRSNSCLSAVQDSETAVVSVDRHGDPITSLVCSSSGLESHGCEPSGSATTSGNQQLLDLNLAAIFQDRLNDPRISSMLKKNGGLGDVELANLLQDKGLDPNFSYMLKDKVMDPRILALLQRSSLDADREHQDDVDVTATDSDRLDTTIANQISLSEELRRSGLEKWLNISRLIFHHLAGSPIRAFIVFTVMFIIETATVAIYRPETIKVINATHEQFEFGFSILLLSPVVCSIMAFIWSLRAEEMLMTSKPQKYGFIAWLLSTCVGLFLSFLSKSSVILGLSLTVPLMVACLSFAVPIWIRNGYSFWIPGREFANRENVSQAPGEKERALFVITIAVFTASIIGLGAIVSAKPLDALGYKGWDADKNSSYSPYATSMYLGWALSSTIAVITTGLIPIVAWFATYRFSPSSAICVGLFATVLVSFCGASYWGVVNSREDGVPLKADFLAALLPLLCIPAFFSLFTGLYKWKDDDWKISRGVYLFVGMGMLLLFGAVAAVIVTIRPWTVGVACLVAILFLVFVIGVIHYWTSNNFYLTRTQMLLVCSIAFLLALAAFLMGLFHGKPFVGASIGYFSFIFLLTGRALTVLLSPPIVVYSPRVLPVYVYDAHADSAKNVSYAFLILYGIALATEVWGVIASLIMNPPFVGAGVSATTLVIAFSFAVSRPCLTLKMMEDAVHFLSKDTVVQAMSRSANKTRNAISGTYSAPQRSASSAALLVGDPALTLDRAGNFVLPRADVMKLRDRLRNEEIAAGSFLCGVKDCLLICPQSLSNIDYRRNMCAHARILALEEAIDTEWVYMWDKFGGYLLLLLGLTAKAEQIQDEVRLRLFLDSIGLSDLSAKEIKKWMPEDRRQFELIQESYIREKEMEEEALMQRREEEGKGRERRRALLEREERKWKELEISLLSSIPNTGSRDAAAMAAAVRAVGGDSALEDSFARDRVSSIANHIRKAQLARRAEQTGIPGTICILDDEPRSTGRHCGELDLCLCQSQKVTLSIAVMVQPVSGPVCLFGSEFQKVCWEILVAGSEQGMEAGQVGLRLVTKGERMTTVAKEWNIGASSIADGRWHLVTVTLDADLGEATSFIDGVYDGYQNGLPLPTDNGIWEPGTDIWVGARPPMDLDAFGRSDSEGSDSKMQIMDAFLWGRCLSEDEVTVLHTAMSPAEYGFFDLAPGDAWHGSYSARVDDWESEEAYELYDQGDVEWDGQYSSGRKRPVHDAVAIDLDSFARRPRKPRFETRDEVNQRMLSVERAVRDALIAKGERNFTDQEFPPEDRSLFVDPMNPPLKLQVVSEWMRPSDIAKDISISCQPCLFSGSVNSSDVCQGRLGDCWFLSAVAVLTEMSRISEVIITPEYNDEGIYTVRFCIQGEWVAVVVDDWIPCESPGKPAFATSRKQNELWVSILEKAYAKLHGSYEALEGGLVQDALVDLTGGAGEEIDMRSPQAQLDLASGRLWSQLLHFKQEGFLLGAGSPSGSDAHISSSGIVQGHAYSILQVREVDGHKLIQIRNPWANEVEWNGPWSDSSPEWTERMKHKLMHVPQSKNGVFWMSWQDFQIHFRSIYVCRVYPPEMRYSVHGQWRGYNAGGCQDYDSWHQNPQYRLRVTGRDALYPVHVFITLTQGVGFSRKTNGFRNYQSSHDSSMFYIGMRILKTQGCRAAYNIYMHESAGGTDYVNSREISCELVLDPYPKGYTIVPTTIHPGEEAPFVLSVFSKASIRLEAV
The following text describes a protein:
Function:
Probably part of an ABC transporter complex involved in host cell binding either through secretion of an adherence factor or through maintaining the architecture and integrity of the mycobacterial cell envelope. Could be required for host endothelial-cell invasion and/or intracellular survival.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNDQAPVAYAPLWRTAWRRLRQRPFQYILLVLGIALGVAMIVAIDVSSNSAQRAFDLSAAAITGKSTHRLVSGPAGVDQQLYVDLRRHGYDFSAPVIEGYVLARGLGNRAMQFMGTDPFAESAFRSPLWSNQNIAELGGFLTRPNGVVLSRQVAQKYGLAVGDRIALQVKGAPTTVTLVGLLTPADEVSNQKLSDLIIADISTAQELFHMPGRLSHIDLIIKDEATATRIQQRLPAGVRMETSDTQRDTVKQMTDAFTVNLTALSLIALLVGIFLIYNTVTFNVVQRRPFFAILRCLGVTREQLFWLIMTESLVAGLIGTGLGLLIGIWLGEGLIGLVTQTINDFYFVINVRNVSVSAESLLKGLIIGIFAAMLATLPPAIEAMRTVPASTLRRSSLESKITKLMPWLWVAWFGLGSFGVLMLWLPGNNLVVAFVGLFSVLIALALIAPPLTRFVMLRLAPGLGRLLGPIGRMAPRNIVRSLSRTSIAIAALMMAVSLMVGVSISVGSFRQTLANWLEVTLKSDVYVSPPTLTSGRPSGNLPVDAVRNISKWPGVRDAVMARYSSVFAPDWGREVELMAVSGDISDGKRPYRWIDGNKDTLWPRFLAGKGVMLSEPMVSRQHLQMPPRPITLMTDSGPQTFPVLAVFSDYTSDQGVILMDRASYRAHWQDDDVTTMFLFLASGANSGALIDQLQAAFAGREDIVIQSTHSVREASMFIFDRSFTITIALQLVATVVAFIGVLSALMSLELDRAHELGVFRAIGMTTRQLWKLMFIETGLMGGMAGLMALPTGCILAWILVRIINVRSFGWTLQMHFESAHFLRALLVAVVAALAAGMYPAWRLGRMTIRTAIREE
The following text describes a protein:
Function:
Transcription regulator required for seed dispersal. Involved in the differentiation of all three cell types required for fruit dehiscence. Acts as the key regulator in a network including SHP and ALC that controls specification of the valve margin. Works with ALC, SHP, and FUL to allow differentiation of the lignified valve layer, the spring-loaded mechanism of fruit that promotes opening. Regulates the expression of the YJ80 marker.
Subcellular Localization:
Nucleus.
Sequence:
MENGMYKKKGVCDSCVSSKSRSNHSPKRSMMEPQPHHLLMDWNKANDLLTQEHAAFLNDPHHLMLDPPPETLIHLDEDEEYDEDMDAMKEMQYMIAVMQPVDIDPATVPKPNRRNVRISDDPQTVVARRRRERISEKIRILKRIVPGGAKMDTASMLDEAIRYTKFLKRQVRILQPHSQIGAPMANPSYLCYYHNSQP
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Sequence:
MQHIKSKSNLFSKVLIQQNRRYTTGNVISNNYLFGDQFGKSHTSKDIFDNKKVVVFGIPGNNPTDDFHQIPSFVKNVDKFYNKGIDNVICLQSADAAILRAKSISLDPLRTIGFLQDKDCKFAVDNALTEDEYLKGLGTESPVHEFKRFALIIDNGRIVFESVEKDPTDYEHTTADVVLKQL
The following text describes a protein:
Function:
Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis.
Subcellular Localization:
Cytoplasm, cytosol. Lysosome. Nucleus. Preautophagosomal structure.
Sequence:
MLFVFQVDTGRMMTFDMSLALESVQNLKSHVELAFKIPVDKQVLLISGGEHLRPDDRVCSYPAGTDTNPIFLFSKAVIESDQPPAASVDYGSEQDLSSKVRESSELPATLSTVQKRTQLARLFCELSQSQMTTCEKLVHEQHLQQQGWSAVVANLEDLYSDLKHRWKLYQDAFNEYIAKRDSYLEFLNHFKDDLLVLQKIPVLPALIESQKLLVPEQDDFSEDKQSGSVRGEMTLHEWISQRDDFMDCLFEICSKGLIQTDEKEFLALQEEIETKLAMTDDVTMKEIKGLGDRLFGLEKLMVDAKRYVNEQMRLAESFQRNQSRASQVKEASILPALCATHLQQLDVLLENHNRLRDITRRCILAKDELSSNLYHRLKWIVFMEDNLSEFDNKLVFHFQNLLSLQRQLEILQQVHTAPTIYLSSIVEVVRRRKVSQAFLLWASDVACHLLTIYNEEIARRKDFQAQIEGHFLSSLFPGMEDFPPSFATQAPSIFDSSLPKLTEEDVENLRRALPDLAECLQIPDTSIIENYFMLKDSKDDLDKTTKTVEDKLIEVVAEVGLASNLDQTMLKAIEGEPQQTTPHGLPHLKDLDKGCESETDTEEFEKVGQSPFDLHFDKGIPSPRPGTQDASTLTEVGERSPLPPKKPPRTFQKPHIQTLDDSNILQRTLSISGSQSNTESFTNLKNPSLESIDELSSLKNFSSNTESCFNSHYQQMQGYSTLLSRSKSISPHTPQSPKDIIQGESPNSPVMGHQQNDFVNDEFYIDESLPSSLSIETGQSQGEFVKQLDTANNVVALLQDNLQISRSEYEKLHSFLIRLSHLSRLACTNLKSELIETKNHILREKVMVEEACGNLKIQMNNIILDKEKQEREIVQRLTVDHELEISDFRKIAQSKNEEIKGLRDENARLSSELRKVSQENLELKEGLEAMSCKSSKEMDDMKKRMDEVLAEKERSTKEEIERLKSEYKSEMENIRARFKLMTMERSPSENSLEKIERGDYPSITNHEALLLQMTENFESEKEVAVSDAVSKESQRWQKILDDRIKQMECDFEQEKAFLIQNIQSRIQQDQEKQINQLREQINNLNLECIKYKDTIQQLAEYREESDCNELMRRIDSLEREKTALKNELKRIKVAEPPPAMAASVAVCEGAAATADAATSPVKTRKRSETSSPKAGKLNIDSCKAGDLVLVVWDIQHQNFKILQESSSLYFLNADCLESLGLKVVDGQPNKLYCYAEVVEKEYCHARKDENYSLLFQPVNRFRVPQGTKFFRVKVKPPPSGKEMPPAQFQAPTQTTHMSQSQTTVSQVVDIIATAGPSHSLPSSPSKISWEKSGSQEAPIPEEKGEDSAVGRSEDSGGKNEEDIEKGTELTENFHIDNHSIDR
The following text describes a protein:
Function:
Phosphoserine aminotransferase (PSAT) is a pyridoxal 5'-phosphate-dependent enzyme involved in the second step of the phosphorylated pathway of serine biosynthesis. Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. Plays an indirect role in purine biosynthesis.
Miscellaneous:
MISCELLANEOUS: Present with 15900 molecules/cell in log phase SD medium.
Sequence:
MSLEREEPQHFGAGPAQMPTPVLQQAAKDLINFNDIGLGIGEISHRSKDATKVIEDSKKHLIELLNIPDTHEVFYLQGGGTTGFSSVATNLAAAYVGKHGKIAPAGYLVTGSWSQKSFEEAKRLHVPAEVIFNAKDYNNGKFGKIPDESLWEDKIKGKAFSYVYLCENETVHGVEWPELPKCLVNDPNIEIVADLSSDILSRKIDVSQYGVIMAGAQKNIGLAGLTLYIIKKSILKNISGASDETLHELGVPITPIAFDYPTVVKNNSAYNTIPIFTLHVMDLVFQHILKKGGVEAQQAENEEKAKILYEALDANSDFYNVPVDPKCRSKMNVVFTLKKDGLDDQFLKEAAARHLTGLKGHRSVGGFRASIYNALSVKAVQNLVDFIKEFAEKNA
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins.
Sequence:
MRIHHAFFRQSCRIMRGIDSARSTPTFVNGTDGMGTIHMLFSKRTHSNTTHSNADSAYMPGSNLHVEHPIVQLPARSLWCKQYPLDISLVRRGEFNDMIGRVRAARHYYQYPSLCAPKIGWNVQMFTLFDGTVFINPINLDALEVEEIAKQKSITFVEAEALWMEKKRREGKTCFAWEPCASCCFLLHFIERPSTVRVRAIAEDGNPFEVTLDKMRARMALHELDHLNGILFTRRIPDTSHVVPLEGFSTMSEWPDDYPSLEARSTFLYTTFTPPYTFITDSVEDAQLLDRKFEDGIYPGCEHDRRMRIESAAFEELQRAQWRMEKTREENSEEYDGVEGEVDEEDQEHCEETAAGGVAVKDNAPQ
The following text describes a protein:
Function:
Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MPTAKQLADIGYKTFSTSMMLLTVYGGYLCSVRAYHYFQRRSSRRQAAEEQKTSGAL
The following text describes a protein:
Function:
Binds to the LIM domain of LIM domain-containing transcription factors. Required for the blmp-1-mediated transcriptional activation or repression of several hypodermal genes, such as bed-3. Regulates sam-10 nuclear localization in PLM neurons. Has a role in synaptic differentiation of PLM mechanosensory neurons. Involved in gonadogenesis.
Sequence:
MYGHHPDYGYGNYGHPPPFAGPESSNSHYGMPPSQGTNSQNNMMMRSQATEPQPIGNTVSPLEFRIHDMNRRLYIFSSTGVSENDQQQWWDAFSHEFFDDDCKLWFVIGSEPVAFASRERYIINRQFIPKFFRSIFDSGMRELQYVLRGPSRECTLANGSQAYENENVLQITRYDQSSQFEVNTEGKLYVEFAPFDEVMNYRIKAWTLELKRSNEFVYNQNTADYRVEAQNPEQENKPRMGFFKSTFNLMTMLKILDPMQSIMSSAKSAPAITPREVMKRTLFQHHQVRQQNMRQQQLNQQMMIPAPEPEKPKPARKRQRKPAANPRGSKKATAAAAAAAAAATNGVPPTVPTASPANNQQFPPNPMTSQFQQMSYPDVMVVGEPSMMGSEFGENDERTISRVENSQYDPNAMQMQSLGQGPNSSMNINGRNMMNQHHPGMQPPPGQQHMPPHSMGSQMPTSMHNPMHMPPGSMQGHGGMPPMPSTMANQMPPPNLPPHTMSNQMPNSRMPPMQGQMPPSGMPGQMSNPNMMGSGMPPMSMSSQMPGSMSNPMPNQMPGGMQMNQMPPPNYSQYTGGPPPQWPPPNSAMITG
The following text describes a protein:
Function:
EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
Sequence:
MSVEGLLSEVKHFNAHHLDAALGEQLFYGGKRVFSDVKPGTSSGGDHGCKGGKSELKGAIHNAKHAADKALNKEGGEDVSKLREEHSALAKKVDDLASLVAELQLQLSTLRQGQTSSVAAPAAAPAAAKEEAAGDDDFDLFGSEDEEEDEEKKKVVEERLAAYAAKKATKAGPIAKSSVILDVKPWDDETDLGEMEKLVRSIEMDGLVWGGAKLIPIGYGIKKLQIITVIEDLKVSVDDLIEKITGDFEDHVQSVDIVAFNKI
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function.
Sequence:
MAVFHDEVEIEDFQYDEDSETYFYPCPCGDNFSITKEDLENGEDVATCPSCSLIIKVIYDKDQFMCGETVPAPSTNKELVKC
The following text describes a protein:
Function:
Promotes the eIF4F and eIF4A RNA-dependent ATP-hydrolysis activity with different efficiency depending on mRNAs, thus providing mRNA discrimination during initiation of translation.
Subcellular Localization:
Nucleus.
Sequence:
MAAAVSSVWAKPGAWALEAEEHEAELKQQPSPTNQKSSAEDSSDFPSLAAAATTKTKKKKGQTISLAEFATYGTAKAKPAPQTERLTQAELVALPTGPRERSAEELDRSKLGGGFRSYGGGRYGDESSSSRWGSSRVSEDGERRGGGFNRDREPSRDSGPSRADEDDNWAAAKKPISGNGFERRERGSGGGFFESQSQSKADEVDSWVSTKPSEPRRFVSSNGGGGDRFEKRGSFESLSRNRDSQYGGGGGSESDTWGRRREESGAANGSPPPSGGSRPRLVLQPRTLPVAVVEVVKPESPVLVIVEKPKGANPFGNARPREEVLAEKGQDWKEIDEKLEAEKLKDIAAAMEKPNEKSTGKMGFGLGNGRKDEERIERSWRKSTEHSEEDAQEEEPAVEGAKKEETEDKPAVEEAKKEETEGEQAVEEAKKEETGGEPAVEEAKKEETEDKI