lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWPNASSLGPCFRPMNITLEERRLIASPWFAASFCLVGLASNLLALSVLMGARQGSSQSRSSFLTFLCGLVLTDFMGLLVTGAIVVTQHFVLFEWQAVDPGCSLCHFMGVIMVFFGLCPLLLGAAMASERFLGITRPFSRPATASQRRAWTTVGLVWASALALGLLPLLGVGHYTVQYPGSWCFLTLGTDPGDVAFGLLFALLGSISVGMSFLLNTISVATLCHVYHGQATAQQRPRDCEVEMMVQLMGIMVVASICWMPLLVFIAQTVLQSPPAMSPTGQLSRLTERQLLIYLRVATWNQILDPWVYILFRRAVIQRFYPRLSTRSRSLSLQPQLTRRSTIH
The following text describes a protein:
Function:
C-type lectin receptor involved in recognition of N-acetylgalactosamine (GalNAc)-terminated glycans by myeloid antigen presenting cells (APCs). Binds in a Ca(2+)-dependent manner to alpha- and beta-linked GalNAc residues on glycoprotein and glycolipid antigens, including alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr also known as Tn and T antigens, LacdiNAc epitope GalNAcbeta1->4GlcNAc and its derivative GalNAcbeta1->4-(Fucalpha1->3)GlcNAc, O-linked core 5 and 6 glycans, and GM2 and GD2 gangliosides. Acts as a signaling receptor at the interface of APC-T cell interactions. On immature dendritic cells, recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and downregulates PTRPN/CD45 phosphatase activity with an impact on T cell activation threshold, cytokine production and proliferation. Modulates dendritic cell maturation toward a tolerogenic phenotype leading to generation of regulatory CD4-positive T cell subset with immune suppressive functions. Acts as an endocytic pattern recognition receptor involved in antitumor immunity. During tumorigenesis, recognizes Tn antigens and its sialylated forms Neu5Ac-Tn and Neu5Gc-Tn expressed on tumor cell mucins. On immature dendritic cells, can internalize Tn-terminated immunogens and target them to endolysosomal compartment for MHC class I and II antigen presentation to CD8-positive and CD4-positive T cells, respectively.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Early endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Note=Recycles between the plasma membrane and the endolysosomal compartment. Upon antigen binding, internalizes via endocytosis and then dissociates from antigen at acidic pH characteristic of endolysosomal vesicles.
Sequence:
MTRTYENFQYLENKVKVQGFKNGPLPLQSLLQRLCSGPCHLLLSLGLGLLLLVIICVVGFQNSKFQRDLVTLRTDFSNFTSNTVAEIQALTSQGSSLEETIASLKAEVEGFKQERQAGVSELQEHTTQKAHLGHCPHCPSVCVPVHSEMLLRVQQLVQDLKKLTCQVATLNNNASTEGTCCPVNWVEHQDSCYWFSHSGMSWAEAEKYCQLKNAHLVVINSREEQNFVQKYLGSAYTWMGLSDPEGAWKWVDGTDYATGFQNWKPGQPDDWQGHGLGGGEDCAHFHPDGRWNDDVCQRPYHWVCEAGLGQTSQESH
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAMYTISLADIIIKARTEVAEIGEEQGGRGNEERERDNEEGERRGDEHEGNRDMERGEEGQQQVAAGEPPPAAETSSSFSNTRGISTTSRGGAGSIITNSGGCRDRLTLLVFVVHILGALAALGFLGFKAIWGAIRGGGKQKRVVEFWVPPVEVAILVGAFMAVASAKATRWWPKQAIHTALWGSFTMTMAASIVMLSFSTPSTVGIGTPLLIFSICDGLYCCWVTRRLDYAVRVLSKALEPTAKFPDLAEPLYWLVGVAAVWTSAWSLALSGASSMEGLPVPALLVFMLVLSMAWTLEVLRNIGNLTVCRVMGLYYTRGIQSIPRFCFERALTNTLGSACLGSALVPMVEALRILARTLNLVEGEDEFLFSCAHCCFRVMEDAFHCANGWGFVMVAVYGKGFVSASRSTLDVIRRRKMESLMDSDITSSVCFLSGILSGAICAIIAGSFAKAYHMEFTATVTLASFFIGYLMTRISMVLPHACVNTYYVCYAEKPDNKLFDETIPNQLKEMSGGAHSTITVG
The following text describes a protein:
Function:
May play a role in stabilizing dense microtubular networks or in vesicular trafficking.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDIPISSRDFRGLQLACVALGLVAGSIIIGISVSKAAAAMGGVFIGAAVLGLLILAYPFLKARFNLDHILPTIGSLRIHPHPGADHGEGRSSTNGNKEGARSSLSTVSRTLEKLKPGTRGAEEC
The following text describes a protein:
Function:
TS is a member of the terpene cyclase group of enzymes. It catalyzes the isomerization and cyclization of farnesyl pyro-phosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes. It serves to branch trichothecene biosynthesis from the isoprenoid pathway.
Miscellaneous:
MISCELLANEOUS: Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.
Sequence:
MENFPTEYFLNTSVRLLEYIRYRDSNYTREERIENLHYAYNKAAHHFAQPRQQQMLKVDPKRLQASLQTIVGMVVYSWAKVSKECMADLSIHYTYTLVLDDSSDDPHPAMLNYFDDLQAGREQAHPWWALVNEHFPNVLRHFGPFCSLNLIRSTMDFFEGCWIEQYNFGGFPGSDDYPQFLRRMNGLGHCVGASLWPKDLFDERKHFLEITSAVAQMENWMVWVNDLMSFYKEFDDERDQISLVKNFVTCHEITLDEALEKLTQETLHSSKQMVAVFSDKDPQVMDTIECFMHGYVTWHLCDARYRLHEIYEKVKDQDTEDAKKFCKFFEQAANVGAVAPSEWAYPQVAQLANVRAKDDVKEAQKPILSSIELVE
The following text describes a protein:
Function:
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
Sequence:
MTMQPWFNEAKLGIFVHYGIYSVDGVPESWALFDQVVPHEQYMRQLDGFTAAAFDPSAWAGLFARAGAGYAVLTARHHDGVALWETRLSDLSVVGRTPAGRDLVAEYVSAMRDRGLRAGLYYSHSDWNHPDYASVRHPRPPHPELVDSPYVSPAPGAEDPRAWERYLDYRDGQVRELLTRFGPDLLWFDGEWERSAEQWRMSELARLIRDLAPDTVCNSRLLGHGDYATPEQGLPMSAPETDWELCLTVNDSWGYRPQDVNHKSVGQLVRYFAQTIGMGGNLLLNVGPRADGTITPEQAQRLEGLGDWIRRHSAAVHGTVGGLPPGHHYGPSTLSPDRRTLYLVCFDPPSETVCVRGLRNAVCRISVLGTGRELAHRRTGGLHDVPGDLWIEAPAPADLAPHGTVLALELDGELELYTGRGRE
The following text describes a protein:
Function:
Cytokinin hydroxylase that catalyzes the biosynthesis of trans-zeatin via the isopentenyladenine riboside 5'-monophosphate (iPRMP)-dependent pathway. Can use isopentenyladenosine-5'-monophosphate, isopentenyladenosine-5'-diphosphate and isopentenyladenosine-5'-triphosphate as substrate.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MMVTLVLKYVLVIVMTLILRVLYDSICCYFLTPRRIKKFMERQGITGPKPRLLTGNIIDISKMLSHSASNDCSSIHHNIVPRLLPHYVSWSKQYGKRFIMWNGTEPRLCLTETEMIKELLTKHNPVTGKSWLQQQGTKGFIGRGLLMANGEAWHHQRHMAAPAFTRDRLKGYAKHMVECTKMMAERLRKEVGEEVEIGEEMRRLTADIISRTEFGSSCDKGKELFSLLTVLQRLCAQATRHLCFPGSRFLPSKYNREIKSLKTEVERLLMEIIDSRKDSVEIGRSSSYGDDLLGLLLNQMDSNKNNLNVQMIMDECKTFFFTGHETTSLLLTWTLMLLAHNPTWQDNVRDEVRQVCGQDGVPSVEQLSSLTSLNKVINESLRLYPPATLLPRMAFEDIKLGDLIIPKGLSIWIPVLAIHHSNELWGEDANEFNPERFTTRSFASSRHFMPFAAGPRNCIGQTFAMMEAKIILAMLVSKFSFAISENYRHAPIVVLTIKPKYGVQLVLKPLDL
The following text describes a protein:
Function:
Symporter that transports one amino acid molecule together with two sodium and one chloride ions in kidneys and plays a role in the neutral amino acids reabsorption. Preferentially transports neutral amino acids such as L-glycine and L-alanine but also other neutral amino acids. Required CLTRN for cell surface expression and for its amino acid transporter activity. The transport mechanism is pH-independent.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=In kidneys localizes to the apical membrane in distal segments of the proximal tubule. Cell membrane expression is CLTRN-dependent.
Sequence:
MAQASGMDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCHTHGGGAFLIPYFIALVFEGIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSVSFLVSLYYNTILLWVLWFFLNSFQHPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISNTGTIQWKLFLCLVACWTTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLPGATEGLTYLFTPNMKILQNSRVWLDAATQIFFSLSLAFGGHIAFASYNQPRNNCEKDAVTIALVNSMTSLYASITIFSIMGFKASNDYGRCLDRNILSLINEFDFPELSISRDEYPSVLMYLNATQPERVARLPLKTCHLEDFLDKSASGPGLAFIVFTEAVLHMPGASVWSVLFFGMLFTLGLSSMFGNMEGVITPLFDMGILPKGVPKETMTGVVCFICFLSAICFTLQSGSYWLEIFDSFAASLNLIIFAFMEVVGVIHVYGIKRFCDDIEWMTGRRPSLYWQVTWRVVSPMLLFGIFLSYIVLLAQSSPSYKAWNPQYEHFPSREEKLYPGWVQVTCVLLSFLPSLWVPGIALAQLLFQYRQRWKNTHLESALKPQESRGC
The following text describes a protein:
Function:
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQTALYISVLIISSCGLVYELLAGTIASYLLGETVTQFSLIIGTYLFSMGVGSWLSKYLEKDLIPKFLEIELAIGLVGGFSSAILYLSFGQIRYFQIPLFLLVILIGILVGLEIPVLLRILKKELQFKELVSRVLSLDYVGALLASILFPIFFAPKLGLMRTGFIFGILNVGVALWGTWVLPLRQSKIIILRAQSVVVLTLLILGFSYSDLITYYSEESLYTDEIILSKQTQYQRIIVTRWKNEIRLFLNGHLQFSSRDEYRYHETLVHPALLAHPAPKKVLVLGGGDGLAVREILKHKNVESVTLVDLDSAITNLFSEHGILKELNEESLKNSKVTVINTDAFLWLEESDQTFDVVLIDFPDPSNFSLGKLYTTAFFHTLKRRMNETSVLEIQSTSPLFARSSYWCIERTIASLGFYTLPLHVYVPSFGEWGFVLAGQRPIQFKKKFPKDLKFLNIQELESIQTFPQDMSRVPVEINRLDNQALVRYYDREWNRILD
The following text describes a protein:
Function:
This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAIHRTVLMCLGLPLFLLPGARAQEQAPPGCSPDLNPLYYNLCDRSEAWGIILEAVAGAGVVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKPSFSTCASRRFLFGVLFAICFSCLVAHVLALHFLVRKNHGPRGWVIFLVALLLSLVEVIINTEWLIITLVRGAGTEGDALGNGSAGWVAVSPCAIANADFVMALIYVMLLLLCAFSGAWSALCGRFKRWRKHGVFILLTTTASIAVWVVWIVMYTYGNRQHNSPTWDDPTLAIALATNAWAFVLFYVIPEVSQVTRSSPEQSYQGDLYPTRGVGYETILKEQKGQSMFVENKAFSMDEPASAKRPVSPYSGYNGQLLTSMYQPTEMTLMHKAPSDGAYDVILPRATANSQVTGSANSTLRAEDIYAAQGRQEATLPKEGKNSQVFRNPYVWD
The following text describes a protein:
Function:
Catalyzes the double cyclization reaction which converts lycopene to beta-carotene and neurosporene to beta-zeacarotene.
Subcellular Localization:
Plastid.
Sequence:
MECVVKANAVAVSFHEWRFRRRKLQAWVTWRSQKRNQALAPMVVRVRPKVEVEVKDEDDSKMGFADEEDYIKAGGSELLFVGMQGRKLMSLQGKIADKLPPISTDNSVLDLVVIGCGPAGLSLAAESAKKGLKVGLIGPDLPFTNNYGVWKDEFKDLGLERCIESAWENTIVYLDHGDPITIGRAYGRVSRHLLHQELLQRCHDAGVTYLNSKVEKITEASNGHSIVTCDEGIMITCRLATVASGAASGKLLEYEVGGPRVSVQTAYGVEVEVENNPYDPRFMVFMDYRDYTKQKKDDLQEDHPPTFLYVMPMSSSKVFFEETCLASKDAMPFHILKKKLMLRLKAMGIRIKKVYEEEWSYIPVGGSLPNTEQKNLAFGAAASMVHPATGYSVVRSLSEAPKYASVIADILKNDVISKQHLSSGKSYNPSMQAWNALWPGERKRQRAFFIFGLALIIELDIQGIRTFFRTFFRLPTWMWWGFLGSSLSSVDLVWFAIYMFALAPNTMRMSLVRHLLSDPTGEKMIRTYLNR
The following text describes a protein:
Function:
Necessary for normal cell division and for the maintenance of normal septation.
Sequence:
MIVIKDAHFLTSSSQLFQCPASLTSEMVVLGRSNVGKSSFINTLLGKNLAKSSATPGKTRLANFFSTTWEDKENALRATFNVIDLPGFGYAKVSKSLKKEWEGFLWELLSVRVSIKLFIHLVDARHLDLEIDKNAKENIQALLRPDQAYLSLFTKFDKLNKNEQHRLFLNAPKPFLINTAHFNALSSKYPTLEIVRQTLLKHLLTNPL
The following text describes a protein:
Function:
NADP-dependent dehydrogenase of the nED (non-phosphorylated Entner-Doudoroff) pathway with highest activity towards glyceraldehydes (e.g. D,L-glyceraldehyde and D-glyceraldehyde), to a lesser extent towards D,L-glyceraldehyde-3-phosphate and glycolaldehyde, but no activity towards aliphatic or aromatic aldehydes.
Sequence:
MDTKLYIDGQWVNSSSGKTVDKYSPVTGQVIGRFEAATRDDVDRAIDAAEDAFWAWNDLGSVERSKIIYRAKELIEKNRAELENIIMEENGKPVKEAKEEVDGVIDQIQYYAEWARKLNGEVVEGTSSHRKIFQYKVPYGIVVALTPWNFPAGMVARKLAPALLTGNTVVLKPSSDTPGSAEWIVRKFVEAGVPKGVLNFITGRGSEIGDYIVEHKKVNLITMTGSTATGQRIMQKASANMAKLILELGGKAPFMVWKDADMDNALKTLLWAKYWNAGQSCIAAERLYVHEDIYDTFMSRFVELSRKLALGDPKNADMGPLINKGALQATSEIVEEAKESGAKILFGGSQPSLSGPYRNGYFFLPTIIGNADQKSKIFQEEIFAPVIGARKISSVEEMYDLANDSKYGLASYLFTKDPNIIFEASERIRFGELYVNMPGPEASQGYHTGFRMTGQAGEGSKYGISEYLKLKNIYVDYSGKPLHINTVRDDLFQ
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSEHTRKSFSDLGISPWLIDTLKALAIYEPTDIQEGVIAQILEGRNCIGGAKTGSGKTAAFALPIIEKWSKDPSGIFALILTPTRELAIQIDEQFAALGANLNLKHALIVGGMDMIRQSIDLSKRPHVVVATPGRLADLIRSNGEETIAGLRRIKFLVMDEADRLLSPTFADDLDDCFSVLPASEDRQTLLFTATVTDAIRQLKYQPQKNNKPPLWLYEVETDNISVPSTLQQSYIFVSSQVREAYLVHLLTIPENAKKSAIIFVNRTRTAELIYSILRLLELRVTELHSEMVQRERINSLGRFRAEAAKILVATDVASRGLDIPSVQLVINFDLPRDPDDYIHRVGRTARAGRSGESISIVTERDVDLVHAIEDRVGTKLSEYEHVSENKMLEYIKEVTDAKRQASLEMIDRGFGERRQKRNEKRLMANGISNKLKNSGRKKKAKNTLSTEK
The following text describes a protein:
Function:
Probable ATP-dependent zinc metallopeptidase. Involved in the assembly and/or stability of the complexes I and V of the mitochondrial oxidative phosphorylation system.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MMLSRISRSISKASRSSIHKGVGYGVRSAVLDEVATGGACITRVDGGIGFVRTYLTLIGGGRKGLSKAYLSELDSVLASPRLRRFFCSEGPKRRNYENYYPKNKIEIPKANNNQKAESGKEEGSGEQGNPQENFIKLNYNILAPLLFIGFILSSILMSPREQQEISFQEFKNKLLEAGLVDRIVVTNKSVAKVYVRSSAPGPDQIGDDAVQGPVAGRNDRRNTSQYKYYFNIGSVESFEEKLEEAQEALRIDPHNYVPVTYVDELNWFQEVMRFGPTVLLLAVLYFMGRRVQGGMGVGGPGGKGGRGIFNIGKAHFTKMDKNAKNKVFFKDVAGCDEAKQEIMEFVHFLKNPKKYELLGAKIPKGALLVGPPGTGKTLLAKATAGESGVPFLSISGSDFMEMFVGVGPARVRSLFQEARQCAPSIIFIDEIDAIGRARGRGGFSGGHDERESTLNQLLVEMDGFATTSGVVILAGTNRPDILDKALLRPGRFDRQITIDKPDIKGRDQIFRIYLSKLKLDHEASFYSQRLAALTPGFAGADIANVCNEAALIAARNESTIITMQHFESAIDRVIGGLEKKNKVISKLERRTVAYHESGHAVAGWFLEHAEPLLKVTIVPRGTAALGFAQYVPNENLLMTKEQLFDVTCMTLGGRAAEQVLIGRISTGAQNDLEKVTKMTYAQVAVYGFSDKVGLLSFPQRDDGFEMSKPYSSKTAAIIDTEVREWVSKAYERTVQLIEKHKEHVAQIAELLLEKEVLHQEDLVRVLGERPFKSLEPTNYDIFKQGFEEENKERKDNPENKTVEDNGSPPVVPEVVPL
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Sequence:
MLIVRPSGRAAEDVETCLNAGWRAEVLSPVEIEADAAGLELLSEQYARADAVFWVSPTAVETAVPYLNLSDGIKAQIAVGQGSRRALERCLVRTVIAPDDGNDSEAVLRLPVWNSLPEGARVLFVRGHGGRDFLMNALQEKGFRTEVAEVYFRRHKPLNFQNFQTENIAAAYITSTELVRLLFGQLPPQFSRFFKSLLYFTHHPRIAEALKREGVCSVETVPTLEAALSHSSISVSDGMVFPGTSN
The following text describes a protein:
Function:
General aromatic amino acid transaminase involved in several otherwise unrelated metabolic pathways. Mainly involved in tryptophan degradation. Active with phenylalanine, tyrosine and tryptophan as amino donors and with phenylpyruvate, hydroxyphenylpyruvate and pyruvate as amino acceptors. Does not accept glutamate or 2-oxoglutarate as substrates. Also active with methionine, leucine, glutamine and kynurenine. Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using aromatic amino acids (tyrosine, phenylalanine and tryptophan) as the amino donors. Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA) with pyruvate as amino acceptor.
Miscellaneous:
MISCELLANEOUS: Present with 7700 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MTAGSAPPVDYTSLKKNFQPFLSRRVENRSLKSFWDASDISDDVIELAGGMPNERFFPIESMDLKISKVPFNDNPKWHNSFTTAHLDLGSPSELPIARSFQYAETKGLPPLLHFVKDFVSRINRPAFSDETESNWDVILSGGSNDSMFKVFETICDESTTVMIEEFTFTPAMSNVEATGAKVIPIKMNLTFDRESQGIDVEYLTQLLDNWSTGPYKDLNKPRVLYTIATGQNPTGMSVPQWKREKIYQLAQRHDFLIVEDDPYGYLYFPSYNPQEPLENPYHSSDLTTERYLNDFLMKSFLTLDTDARVIRLETFSKIFAPGLRLSFIVANKFLLQKILDLADITTRAPSGTSQAIVYSTIKAMAESNLSSSLSMKEAMFEGWIRWIMQIASKYNHRKNLTLKALYETESYQAGQFTVMEPSAGMFIIIKINWGNFDRPDDLPQQMDILDKFLLKNGVKVVLGYKMAVCPNYSKQNSDFLRLTIAYARDDDQLIEASKRIGSGIKEFFDNYKS
The following text describes a protein:
Function:
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and involved in the inositol cycle of calcium signaling.
Sequence:
MVLTRQVLEEVENTFIELLRSKIGPLVKSHAGTNFCSYDDKANGVDLVTALDKQIESIIKENLTAKYPSFKFIGEETYVKGVTKITNGPTFIVDPIDGTTNFIHGYPYSCTSLGLAEMGKPVVGVVFNPHLNQLFHASKGNGAFLNDQEIKVSKRPLILQKSLIALEGGSERTEGSQGNFDKKMNTYKNLLSESGAFVHGFRSAGSAAMNICYVASGMLDAYWEGGCWAWDVCAGWCILEEAGGIMVGGNCGEWNIPLDRRCYLAIRGGCESMEQKRFAESFWPHVAGELEY
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MRISERAFMDIAIGTKAPRRIVFKLFPRKCPSAVKNFIELCSGNVSTDTYESGNRDKLISESALPQLTYKNSTFHRVEKGYLIQGGDIVTGRGTEQLSIYGGTFSAPEEVRASVFDKPGLVGTASSSPNAHGSQFFILTAKEANHLNGTCICFGQVADGLDVVQEIEQVPIDPSGFPSLKVSIVDCGVLE
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNPLIVVASIIVAGLAVGLASIGPRVGQGTAVGQVVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALVLLFANPFV
The following text describes a protein:
Function:
Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.
Sequence:
MAGSKIADLQLHKLDELDCLIQGLLYVDSVGFNGKPECYYFENPTNPELCQKKPYCLDNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALDMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNMMSKEKRESISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLLAYAMDFWSKGQLKALFLEHEGYFGAVGALLELFKMTDTQ
The following text describes a protein:
Function:
Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L; cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. Plays a role in cell growth and migration.
Subcellular Localization:
Cell membrane. Cytoplasm. Mitochondrion inner membrane. Mitochondrion outer membrane.
Sequence:
MWLALGCLQLGEAGPAGLPQAGRAAAAAAMRRQPAAGRDLLAQEPVPPGSRDAQLEDALLNLGSVIDIAGFRRAVKEALSAVLPRVETVYTYLLDTESRLVCEDPPHELPQEGKVREAVISRKRLSCNGLGPSDHPGKPLARLVAPLAPDTQVLVIPLVDKEAGAVAAVILVHCGQLSDSDEWNLQAVEKHTLVALRRVQALQQRGPSADPEAVQKPPAGAAGDQEGGISYTDQDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLEEELSFPLTTGRLGQVVEDKKSIQLKDLTPEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVEDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFSSFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLCKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRTNKQHHSLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPQLDGTRGPINGCCSLDAE
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
Subcellular Localization:
Nucleus.
Sequence:
MGVTQLLPFLAKSTRPCHISEFRGRTVAIDSYCWLHRGARGCAMQLAKNEDVDSYVHYCMKYIKTLLSHDIRPIMVFDGRHLPAKMKTEEKRRESKKLARKQGMECLRLGHTSDAYKFFAQSIDVTPEMALKLIRECRKLHIDCIVAPYEADAQLAYLNIKGFADCVITEDSDLLLFGCLKVMYKMDSHGQGQLVEADKIHISMKMKQACFTMEKFRYMCILSGCDYLDSLPGIGLRKALKFISMTAETNPNIFLDKLARYLKMPSLIVTDEYKQNFLVANATFLHQIVFDPIQRKLVPLTPVTTDVDYCQNAGEFFDPNTAFQLALGNLNPLTLQPIDNWTPTKGIVSDFSIWSQRFRFRSPPRRAAPAASASISTPLFKFETFDRAAIEASLAQHDQEVEKELAFYNMPPPASEQKMDVDSIESRESSSSGSPVLNKNPFMKKKLSKFQSTSASMPRVVSRFFSSSDGSENVDSSPSSVQTPESTSPVILTPDSGSPSEGISTLVECECILEVEDSVLLSVENLPNTERKRRSEDEHGGKPGKKAKRQPTIQEMFKKMQTR
The following text describes a protein:
Function:
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MLKKSIHTMIITMISRVLGLFRGTLVAYFFGASILTDAYYSAFKISNFFRQLLGEGALGNTFIPLYHKKKKEEGEERSREYIFSVLNITFLFSFLVSILMIIFSSYIIDFIVVGFSDELKIVASRLLKIMSFYFLFISLSGMMGSILNNFGYFAIPASTSIFFNLSIIFSAIWLTKYFDIDALAYGVLIGGILQFLVVFFPFLRLLKTYSLKIDFKDVYLKLLGIKLIPMLIGVFARQINTIVDQFFASFLVAGSITALENASRIYLLPVGVFGVTISNVLFPTISKAAANNDKEGTNKGIISALNFLNFLTIPSLFVLTFFSKDVIRLIFSYGKFNEEAVRITAECLFYYSLGLLFYVGVQLVSKAYYAMGDNKRPAKFSIIAIIMNIVLNYLFIKNFQHKGLAMATSISSGVNFFLLLFIYVKNYVKLDLKNLIFTSIKICVSSIIATGAAYYINNVILKLIVFSAVFLLQWVYPIYKYRERIFYKK
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MMLTECERKLGEGLLRLPFEHGCRYGPEAERDLLELLFRSLVGFDEDRLRQLFPNGFPEGPWKLAEAQGAQEGAEYTEAARGKRCGHIFRAGEATYRCVTCAVDDTCVLCSKCFDASDHSGHQYQISLSSGNCGCCDCGDDEAWRYPLFCAIHTDRGDTKGKQRAQTFLPPDWAENIRLTISRVMDYFCDVISCSPEQLRLPKTEDGIRQDEVASRLTGDWYGGGDQEEEEPEWACALWNDEKHTIRDVANQVARACRERIRFGEKKAYETNDIGRTVVRQSKDLAQLLKVSQVLEQIKVTTTVRSARDTFREQMCGTIVEWLSDIAGCTVLEDDQILRHVICEELLSPWRQGSGAYNASIGLKGIDDHARQDHSPYHTLMLAAVAPQAQVIFAPEADIEGDEEDNGNGNEAEGDDDEDHADTHEDADDEDEEMEIDLNRLREEVEEDEDMVMGTIDDSVTLEMANMLEDMRQRRMALMDEQERREREELQAQQEQSRAQDAQQAQHNTLPAGEEHCADISTVAIPKTPSGVVKPPPARAPGYWLARPAGFSFRENVPAYEDFYQRTRLDWMILFDLRLWKKTRTDLRDLYIGTVVSVPQFKRILGLRMSALYTALAQLYLIADREPDHSIVNLSLQILTTPSITEEIVRRGNFLTKVMAILYTFLTTRQVGEAYEVNPNATLAFDAGTVTNRRLYHFFLDLRYLLQSEYVQHHVRTEEQYLSQFLDLVKLSQGICPNIRAVGEHVEYEPDAWISASILMREINRLCRQFCEAFRNPEVDGGKNLFRAIRMATVSAIVHSAGLERQRFEQAEVKEYVRFKLLPCFDFEVDQTGQIPRHRVVDFVVEKGSISFHHALHYTLSWLLECARNVSGGQMRDVLLDAARMANDNIIRDSSLTPDDFLLTMFDYPLRVCAWLAQMKAGMWVRNGLSLRHQMSQYRGVSSRDFAYYRDIFLLQTALVTCDPSRVLASIADRFGMVDWMTRNYTPRAGYEDAQIIDVAEEFVHLLIILLTDRNSLEAIDDNETVTRDNIRRDIAHVLCFKPLSFSDLSTRLSDKLLDSSMFQETLEEVAVFRPPEGLNDTGTFELKPKYIDLIDPYSAHYTKNQRDEAESIYREWVAKKTGKKASDIVFEPHLRPITSGAFSDLSHFTKTPLFAQLIHHCLDYVMSSKDCSPNIPSTRVETFLQVVLHLILAATLEDNSQEDEMADEARESFISNALSRARGTQAGNLTIIGLLEKISVMPEFSACGPKIRHILKRLWQKRPRAYASATASLTFPFDRVDTNSPAIDVDSEKELKKKQALERQARVMAQFQQQQQNFLNSQGAIDWGEEDFSDLESEPEAAPEAKLWKYPSGTCILCQEETNDSRLYGTFALVQDSNILRQTDVQDPDWIREVLKTPLSLDKSAEDIRPFGVAGENQITVKRLDSTGGEVISEKIGLSKGFDAKNTVRGPVTTGCGHIMHFSCFEVYYAATQRRHTHQIARNHPERLFLKEFVCPLCKALGNAFLPIVWKGKEESYPGPLSTTVPFNSFLSTELRTALSQPQNHAILVGEDSLQLQLYQDMFLDYLQRAFVPPVANRIEQLVSGSPPPTTEHPPQVRMPMPGLFPSHEDASASSPLQPVSSTPDESPMFELLQIYKRLKKTLRTNHIHSTFNHPPETIHNVNDDLVHTDSLFSSFGYSIAAVEIAQRGVESEAGSTLLDKIPQLTLTHLRVLAETALSYAAVGCLYKSGGNHSRAADEFQEIHRQKICQLFVGYPFLVGTALLDGARDIEPMLAKDTFVFLAECSLSLLPVLKIDVHHLVQLCYVAEIVKVAMTYILHPQGLKKELAEHGDAHYLLDVELSDERYEYTRHFFNAIVGELRENSFRHDEGSSFAADSGYVKDGEDSATPGIIIALRRLVSSYALAFLRKVVILLHVQHGVEFLTAGFNDMGASELDRLTKLLQLPSLDDIFSSVNPAKKANELDAVVAGWISHWNSSRVGTRITDHQLWPSLPHPAIFELIGLPKYYDILIEEVNRRRCPKTKKELTDPSICLFCGDIFCSQAVCCSVDNRIGGCNQHLQKCGKNVGLFINIRKCAILYLHNKNGSWHFAPYLDRHGEVDPGLRRNRQLILNQKRYDRLLRDVWLNHNIPATISRKLEADINNGGWETL
The following text describes a protein:
Function:
Potent inhibitor of the complement membrane attack complex (MAC) action, which protects self-cells from damage during complement activation. Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Localizes to the cell surface. Soluble form found in a number of tissues.
Sequence:
MRAQRGLILLLLLLAVFCSTAVSLTCYHCFQPVVSSCNMNSTCSPDQDSCLYAVAGMQVYQRCWKQSDCHGEIIMDQLEETKLKFRCCQFNLCNKSDGSLGKTPLLGTSVLVAILNLCFLSHL