lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone. May be involved in sterol transfer between intracellular membranes.
Miscellaneous:
MISCELLANEOUS: Present with 1170 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Localizes to puncta in the cell periphery representing cortical endoplasmic reticulum (cER)-plasma membrane (PM) membrane contact sites.
Domain:
The VASt domain bind sterols.
Sequence:
MHEHKAELRLITVALNEASTDSPSFRASVNYFHTRMESLSSWMHSTVDYVENTYKPSFQDFQRIKETLFSQLLPSPILLSNGFVSNQPYTPLLVRDFTRDVSDLSNTVMKIILGDENSQYTAALSALSSDAINPYFNKRKTFEYYQRKYDSFLTDFLAATNDGNTLIPQNLQNETFKLVDIKHKYIEASLDLTEAISLMKVNLDKFLIETIDIVRKNNVITTKDTKDVIDITPELTETLKDWTDWIESNLQTLQALSSKLSEAKYAILKLSLARMKPSRLIQDYDLKSIQNLKFNLPKSISNGNNSEEKGLSGWLYMKTTVGHDPKRVVWVRRWCFLQNNVFGVFSLSPSKTYVEETDKFGILWITVEYLPKEPRNFCFKLRIQNPNCKTEEENTYIDIILQAESIDELKSWINTLTSHKRIALSIKEENDPRYQLARKKIEPQFFEFASSSSTSTDKLLTSFSSKTLTLVEELKKNYMSEDDIYSIIDNKAYHLRVISTPIATQLTHLALFSTFLSVSNYYPCATQANTWGTANWNDLSYLVNPLKGSSVHKPATVSNSSRFSVSYPDYYPYSLKVDDIQFRSIFFSVNHDFLQVPKELVLLRYSSVWCPNNKQKFASMAFVTLNHIYVYLNISGFSYLRRIDLLDIDSIEYDKSPKHVSSRMLHMQRGDGLRFNMSVFFTDRRAVASKLQFLIENKAMHIPKGEKEVLEIFQELDEEIENEKKIIKDNLSESEHYSKDYDYLLKSTYDHHFENTNETPMELMSRKLRLEREAWCYFQDNFKVGSKTLFHVLFGDKSQVFPSSLFLCKKGSNLNNNSYWERIRRAKEDASCQFELCRKLQFQLNRTSNFIKDLLWLKDDNDNFKLVLQQRVTKIKQGYYFEVEEGPIIVKFPLCHPLLLRVRFIIAECITSQGESLKKCDLAILYDFNYVESIDKLNTKVEKLWLFERIHLNWALRYCKLEHSEINRKTREYLKKFNDREKMSDVIKLCGFLGVLPKERIENDEKAGDFMQPVYINYDFLSLSKIFTKLTVFYLSSVIIKTMKVLLAMVMVIFKCFSKVNKTLYYCLLISAVTNLFFVGKSIHSYFSVKSAETLFQNYANGDQRGLQIMHRSLTVPDLNLLTRKMMDNDQENPVFKRFDEDKNAYQYKGTRQEIAIKRNQVLTELKILQNTEKELVQGSYRKFIITERDKCITTQNEIFDLWINDTKLQDYCMACFAEYNRLSAIPV
The following text describes a protein:
Function:
Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.
Sequence:
MTGPKCMTFFSNLNGPDMGLVLVYVTVSGRKTLAWLKSGDAGDRWIMEQVLINETREYKHTHCCAGLHNNSIVPFAGEFVLWVVEFALTFFVVNNRFFAVVNRPTEKRCRVSSSGDEIEQEEVSAAMLEMLEQLRKKKVTLEVKRDTSSFGDTAIDDILFTNGSCAQETRLFHVSTTNGFYQIDNEPPTDNWFNQFSFLARRTTGNLKKQMFFVYGDKSKTTDKWNGYENILRTYFGKSAFPVDFFYEYTGSLNQSRPVFAVKRNGQAQQIVLEMGEYEGCCKETDVLSINVQVIEDHTCFSGWISSGSSGCLRFYVNDKRTWGGARAECRRIGGDLATIRDSNALSDISKILETIPTARAPFHVGMCNTVTFVNQNLTWVDGKTVQSSLWKSGYPKTGDKPLCAGLTEVHPGLILHACSLRTGFICQRNSVDMAAKKPTNSSAEQSNSTKSSFAVDGFPNTCFYTKASNPWWSVDLLRSMYVYSIEILNNKGCFHVGLSNMEISVIQGARSQRCGDVMSYGSTDWLKAGCKPIRGRTVMITLDGANATLILCIVTVQAYGSTTSSAQISPIESAEEIRGIHRDIWYTPIITQGLATIRDNYVYSSSPQGATWGRDFETSQEVSEDHGQLITSYLQNNYNLVLVLVLVLVLVLVLVLVLVLVLVLVLFLVLVLILVLVLVLVLVF
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MVSQISKKEFLKLYRDILKSHRILQEPMKSMGDSYVKNEWRLHKKVKDNKVLNKFYTEWDQYLNFMDKQRESILDQAMEKYQQEQRAKSNDYTNEEKELFINTLVGKDLDEFQINQLNKDQKEKLNQLKNETKNLFNEFNQDQPENNNGNNNNNNNK
The following text describes a protein:
Function:
Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness.
Subcellular Localization:
Chromosome. Nucleus, nucleolus.
Sequence:
MAARKGRRRTCETGEPMEAESGDTSSEGPAQVYLPGRGPPLREGEELVMDEEAYVLYHRAQTGAPCLSFDIVRDHLGDNRTELPLTLYLCAGTQAESAQSNRLMMLRMHNLHGTKPPPSEGSDEEEEEDEEDEEERKPQLELAMVPHYGGINRVRVSWLGEEPVAGVWSEKGQVEVFALRRLLQVVEDPQALAAFLRDEQAQMKPIFSFAGHMGEGFALDWSPRVAGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREPFLLSGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADHQITQWDLAVERDPEASDVEADPGLADLPQQLLFVHQGETELKELHWHPQCPGLLVSTALSGFTIFRTISV
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MWLGEGGCVLRPRTMAPSGGGVVQADAHRHAVVSHHRDRHRRRIISPYRLRLKPKLIVQQYEIWRLVTNFLYFGKWVGLKLASELHTKAATAKGTVHESYIGGSFGFVCQLHWKSPKRIQIWAPNFEFSWVFEAGGAIAYQCLTLTVYWRWHRLVRTSQVLGGGTARFSGSGRCHRLHYFSSLVGLQTWPKPGMIAGHAYYFLEDVYPLMQGHRPLRTPFIKNIICGGKWPNQGMQNLTLEHGMFIKRVTKKIVLQSFFRFCGSSHKQQGNMFHFLTFFCVFTASCEYQKELIW
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MCPTTVPVTGADMDDTVLAKLRASRAAIVSVLSDAAGAEAAIDEAGDRLTDLLSSASSPSSSNLQSKAVAARALRARIDRAVAPAEPLLAALRRVSSLAEEAAQLPENPADTESAVAFVDRVDQMRDAIEDVVARGDEAVRRVEEAVGFLGRTTTKAAGRCRVRRLTEAASALRAVYETEAEAMRFEGPLDEALLGLQDLFEAVLLRLKHAAPADDAGAVGDTDEYELGTDDEVDAAARMAKTLAGNDCLDICVDIYVKARYRRAAKAMMRLDPAYLKAYTAEAIDGMEWEALESSMALWSPHFHVAIASVLTAERRLCARVLAHLPPAVWPECFAKIAARIVAAFFRFADGVVAAEREPQRLFKLLDMFDAVARERDRLDALFSGESATLVAIRERASEVERALARAAAGVFYEFGLRVETHYIAGAGAGTDAVHVPKIVRYAVNYLKCLASDDYRGLMDTALRAERERGGAGDGDEDGGEAEGGGGRAALAEAASNVLEALHRHVEAARKVCADAVAGHVMAMNAYWYIYMRTRGSDLSKLIGEEPIKRRYKTSAEEAAWEYQDAAWSPLVRLLGGSGGKAWPADEAREKAAAFAGVLEERVRKHGAEYKIPDGDLRAQIKAAVTKAVRGAYAGFVKANEKAVAGGRRELLQVDVVESMVRRVFEEMGDGEAGGKGMGRTRSSGRVRRESGNIDGFEAN
The following text describes a protein:
Function:
Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes; [Isoform 3]: Potent inhibitor of type I IFN receptor activity.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: Soluble receptor.
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein; [Isoform 2]: Cell membrane; Single-pass type I membrane protein; [Isoform 3]: Secreted.
Sequence:
MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAESAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMDMVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLIDPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGRITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPTFPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR
The following text describes a protein:
Function:
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Domain:
Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
Sequence:
MRLTNRRFSTFLGNALPSKKKGFIFMSQLLYLRTFSTHTSYLRSSWQAILNYKYIYQNAEAVQRNCINRNLQAIAETVPKIRSLIDEKESLKNEFFPLLSLKKEITLQIERCSDPNERGKLVNEAKGLKKKTEEYNKIISKVTNDLYQYCLAVPNTTLPTVPVGPEDKAVVVQKIGSPLVKKTGSLKDHLQIANEGINLEDAAQASGHSFCYTTGDIALLEMAITNYAMDFAISKGWCPVIPPTIVRTDIALACGFQPRDEEGQQIYELDSYTSPLVSSPKQCLIGTAEISLAALGFKKTFNNFTERKVVGVSRAYRREAGARGKENRGLYRLHEFTKVELFAWTHPSRSSEMFNEIVNFQKEFVETLKIPARILNMPTAELGSSASQKYDIEAWMPARQSYGEITSASNCLEYQARRLLTRYRNDKDSGFVHTLNGTAAAIPRLIIAILENHQQEDGTVKVPETLVPYIHKEYLFKAK
The following text describes a protein:
Function:
Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MIPTYSSSLLKASTMYVKAFLAFSCCLLKKTHAFHRPKSPQPFQPESQAGRTPVDSSAVPTAPAKQHDAADSQGPSLHCDLWKSAYDQLYQEERDILSEVQATTRRKNNDKKRSQTVAVIDDVIQITEEQYKEYQKKGIKIRRSGGEDFDLRKLSRKILIAALSFKDVVNTVVSFDPTHHAASAWAVISLGLSMTQNRLDLQDALFESSEFLAEVLSGCAYIETTFYQNGPIAKSKIESATVGIYKAILRYAAEVLTAQNAGVGRKILYSVTPITDQRLMELRSSVETEWQKLCQLVQFDALDKGLQNDKRAELYLARIDDEVSKVLRVLIQDFSLPVAEGALYNSYANQGDDTCLPNTRVDLLSEISKWAESCEGKHIFWLNGMAGTGKSTIARTVAHSFDEKGKLGASFFFKRGEADRDNARRLIPTVTKELMKKIPQLVPGVLAAIERDPDISSKALSHQFDALLLHPLQELKLHRNINMVVVLDALDECVSADIHILLKLLPQLRKSTSIRLRIFLTSRPELPIRRGFKQSGDHQDLVLHELPSPVIEQDIRLFLRVRLSDIRKENSLPRDWPRDDEMEKLVTLSIPLFIYAATVCRFIGDGKRSPTQRLATVLQSEAAKPSSQMERVYRPVLMQVLGDDPKESHDLVREFRNIVGVIILLATPLSVYTLGQLLSTSVEDISYLLDKLHSVLAVPEDINSPVRTLHLSFREFLLNTGEEDLHVNERLTHGEILSHCLGVMKSGLKRNVCGLSSYGTLREDVASQVIDQYIPQALQYSCRYWMYHFEKAGDKEREKDIFPFLKEYFIHWLEAMSLLGLASETVGIIGTLRTKSVTDVEFLKFLQDAYRFVLKHAQMINMAPLQVYCSGLAFSPTDSIVRRIFNNKQPSWLPVLPQVHKSWSAELQTLEGHSSWVSSVAFSPDGQRIVSGSDDNTIKLWDAQTGSELQSLQGHSDSVHSVAFSPDGQRIVSGSDDNTIKLWDAQTGSELRSLEGHSRPVYSVAFSLDGQRIVSGSDDNTIKLWDAQTGSELRSLEGHSDWVHSVAFSPDGQRIVIYGSKIRLWDAQTGSELQSLQSHSDYVTYAFLGNFRVEHKQGSHISVESSWVCFRGERVIWLPPELREPSCRAINHDILALGAWESWALYFDFHGLEISSHLDFEGFYIKWVFITSEVVTMSCSRCLRDETSQRSYRANRIFDQSCAHYIPLGCPSTFAFNCYSAYRADFRESSRSGYGSIKYPKVGAAGQKNDYQMFVGQSDFENDCTLTRVYRN
The following text describes a protein:
Function:
Involved in the transport of copper.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MMHMTFYWGIKATILFDFWKTDSWLSYILTLIACFVFSAFYQYLENRRIQFKSLSSSRRAPPPPRSSSGVSAPLIPKSGTRSAAKAASVLLFGVNAAIGYLLMLAAMSFNGGVFIAIVVGLTAGYAVFRSDDGGADTATDDPCPCA
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MEGRNVIINSETGSGKTLCNYICNFFISCSSTGYLLPLINKLYSDYELGPIVPRALILAPTAELVHQISTVFRSLVPNNQFTASIVTSKSTLLIKDNTAAIIGVPHNITTYHAPSLLNSIETIIVDEADALVTGSASRDVWTMLNCKRLMVESKKADEEKQTKMTEVNVEISSSSKRIPNLRRGSSITRHGLDSKNCQYLFVGATLPSNNNEKSEYGIIHGWLKKLNPTLVHLARTENVHKIISTLQSDCIMTKNDEKLETLLHILDKVKSNYNDENKMTPNKNLNRSPVAKGDHLKMIVFTNTAYHAFALYRFLDGTDPNLMKEPQRSVLPLHFELLPPEQKEELINTVNFEKNYFKAQYSNEWKGRCGILHKDIPIEVREEILNKFINGDIPILITTDIASRGLDIPNVTAVIQYDFALSAVDYLHRAGRTARSGNEGQFFSMATENDSFLVEAIRNIKASESFDSVFSRNRNLRRKLRKLKKQQTDQNDIIDSDEPNSEAVNY
The following text describes a protein:
Function:
Hydrolyzes terminal GlcNAc residues from terminally unbranched N-glycans and from chitobiose. Hydrolyzes beta-1,6-linked N-acetylglucosamine and beta-1,4-linked N-acetylgalactosamine from pNP-alpha-GalNAc[beta1,3Gal]beta1,6GlcNAc and pNP-beta-GlcNAc-beta1,4-GalNAc substrates, respectively, as well as beta-1,2-linked N-acetylglucosamine units from the non-reducing end of N-glycans. Hydrolyzes GlcNAc residues linked to alpha1,3- or alpha1,6-mannose branch, but has low activity on substrates with more than one GlcNAc residue on one of the mannose branches. Releases terminal GlcNAc moieties from the N-glycopeptide Gly-Glu-Asn-(GlcNAc2Man3GlcNAc2)-Arg with high efficiency. Has moderate hydrolytic activity on the chitobiose moiety of N-glycopeptide substrate Gly-Glu-Asn-(GlcNAc2)-Arg. Does not hydrolyze GlcNAc residues from N-glycan structures bearing a bisecting GlcNAc moiety (beta1,4-linked GlcNAc to the beta1,4-linked core mannose). Potentially capable of cleaving the specific glycoside linkages in the process of mucin degradation in human intestinal tract (Probable). Hydrolyzes synthetic substrate pNP-beta-GlcNAc with high activity and pNP-beta-GalNAc to a lesser extent. Does not hydrolyze pNP-beta-glucose, pNP-beta-galactose, pNP-alpha-glucose, pNP-alpha-galactose, pNP-alpha-GlcNAc or pNP-alpha-fucose.
Sequence:
MARPLPILGGILLSFSPPAEATAQYSIIPEPSRTELRQETAKTLQLLSDQEVPTLETDAYRLTVTPQGAHLASGGREGRIYGLATLRQLRDQLAGQPEGIPCGVITDKPRYPWRGLMVDPARHFIPAADLKKFVDMMAYYKFNRLHLHLTDNQGWRLPVPGYPKLKSVASRREESFGDGIPHEGMYTKQELKELVAYCAARGIDVIPEIDMPGHNQALHAAYPEFFCFPKPDMNVRTTAGNSKELVCPQKPEVWKFYASVFNELKDIFPSGIVHLGGDEAPTELWEKCPLCREARTRAAMKDEQEQMKAFFAKTAALLAKNGQTPQFWYEGNAGIYHPGETVYAWRQGQALQSIEKTKKAGLNLIMASSEYCYLDFPQIQGQRNWGWMKTTTLQKCYDLDPAFGKPEKEAGHIRGVHAPVWAERLPDLNHLLYRAYPRACAIAEAGWSPMGVRSWENFRRKLADHRQFILKRFNYDMERTQGNEPAFRWENNK
The following text describes a protein:
Function:
Involved in the biosynthesis of the acyclic C50 carotenoid bacterioruberin (BR). Catalyzes the reaction that introduces hydroxyl groups to C3'' and C3''' of bisanhydrobacterioruberin (BABR) to generate BR.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGSGKDRTLAGWTLPETKTDATAQFDRFVTENRFTIAVVFPLVGAVTLLASAEGLLPDPLAFNPYFVLFGTFVMRLPLVAGIFPLVDRRAGLALVALTLYSYGIELVGVRTGWPYGEFTYGVDLGPMLLGDVPFGLPVFFFPLVLNAYLLVLLLLGNRAASTTVRLLSTLATVMLVDLVLDPGAVAIGFWIYEMPQFYGVPWQNYAGWLLSGSVAVLLFDFGFDRAGLRRRLRDCPFMLDDLVSFVLLWGGINLFYTNWVPFGLAALLGAGLLWTDRFDFDLSETRLGRAVWR
The following text describes a protein:
Function:
Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Note=Membrane-associated protein found in pre-autophagosomal structure and other perivacuolar punctate structures.
Sequence:
MKIAVETTLFDFFVIDQFKKSTFSAPNTKVDTIKGCINKFIEQFNVYDEQHIFWQPPGKSNVRLLSNANDFGQLGNFLHKKIKCNIFIGEEALRKYDLNICGPYDKFVENSDPSVKKVVNRDDVMLSRKCLNIISEQLSILEKSISKAQNQVLQSSEVEGKKCIILPEDKPELIKFFSKFETSVQLQEVYEGYKVYEKLLQKFGGQKKRMESFLNENTPMSGAEAIKQINISEELKEKGERLTTPNDPLLHVEVSNEDNSLHFILYNKTNIIIPGNCTFEFSSQISEVFSIKMGPHEIGIKGQKELWFFPSLPTPLSNYTMKVVNQDGETILVGKCADSNEITLKSPLASFSTGSFQTGSFHTLQDPTNVFRADALSSPDESSIMSTPFLGETDEVYNSGSTLSRPFTWEEI
The following text describes a protein:
Function:
Catalyses the transfer of galactose onto proteins or lipids.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MHLSDDPPTFAEIAKIFAMLEVGGYHPGPKFCKPRHSTAIIIPYRDRNTHLRHWLHYTLGILLEQQLEFTVFVVEQEGNDVFNKGQLMNTAFMWALQQSRAKFKCFVFHDVDMIPEVPGNFYTCADGKTVTHLSPYIDKFNYTANKKNGLTVGGAVAFTEWQYRAVNGYSNVYWGWGGEDDDMNLRIKHAGLHRTRPDSTFGRYRMIPHSHDNGNPINKIRHKLLKEASVRMATDGLSDLDTKVVGVSLYATYTHIMVRLKVPQLPWLETTVASQTSESTVAPIQETPISYTVKKRSEIVAKKTEKIENY
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLNAVACKMALSKQDSSMSLMQKALYQQHLDRRFCDLIVKINDEVFHMHSCVIAAACPKLHDVLQERNNFHSEPLNQDLKYFQQESFTPTCFSFLLTFMYTGNLQWENMKSEDIQDAFIAAQWCGFDKITDECRKLMTECDGTHKDAIELCENGESEEGIGDTPTTTTTMVVLAKDDDEEMQQVVPYCSNDDIGAVGSVKKLAGMCYEDAMQNQNVIYCMLCAEMFSATDDTLFIEHMEKHAVQSGITHHRSADTQSIKSLLSKYKPINSDDDDNMENGEQEEDMSTVAIYIDDEDQEYQDPDEKDVKKKRLFAKCFSCHYCHKRFTSQKSKKTHLRTCKVKLHRQNKVDGEEEDDEGKRKRGWRVKAVRKSKAVPTKMWLCPECPTLVFYKKRDQTAHMRTQHGNTKQFVCEECGKKFQGKSALNWHSRIHSGEKPYVCHHCGKAFTELRSQLAHERVHTGERPFLCTICGKDFSFRQSLSRHMKFHAGVRPYQCSICGKSFVLKHNLTEHQIRHEKHKLVKCQSCLESFYNQELLMEHRRHHHMSETGPDVIDMTVPPHKRLQISDGTEQDQYNMTLEDAILETY
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MFDQHSYLPLNLSHLFKSNYRSLSGKIDHQSEWQWMKVSWTCSSERFPHNLLFLLCNINNNNFFSWAKEIMTPAKVLSLSLSLCVCVCVCNDQVDLHTQLWHECAGLTVKVPRVGDKVFYFPQGHLQQVEVYMKQEGMSDIPSYGLPSKILCKVVCVQLKAEVDTDEVFAQITLIPDCEEPKGSTFRSVPQKIPATSFRKKLTPSDVIKQGGCNLHKKHVDQTFPPLDMGQDAPSQELFAKDLHGKIWNFHHICRGVPKRHILTTGWGKFVSAKRLVVGDTCIFLRGQNRLYVGVRRAVRLNKLSTDLSCVNMQHGILLTALEAINTRTEFTVYYHPRISPSGFIVAYNDFMESLKVNFSPETRVEMVLDEGGEEPELNLKKLLLIKENGVGRFSGIIIGKEDVDPSRWPGSEWHCLKVWWHGTASGDVPPKRVSPWSIQSVVCDAQPQKRSMIGYNNNNELGVQGEGIRMREVSIPEVNKIPREDDERSKKCRVFGVDIGGHTHTHTISNTHPPDSSNAGNQQSSPSYIKVLKHGSFVGRCVEVSRFSGYGGLMWELDRMFGFQGGLVSGTSGWIVTYDDDNNNNNNAAADGDANKKLLGDVSWSEFRGVVRKMCICPKEKELEAATWNKISG
The following text describes a protein:
Function:
Component of the type III secretion system 1 (SPI-1 T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. SipB/SctE1 and SipC/SctB1 are inserted into the host membrane where they form a pore and allow the translocation of effector proteins into the cytosol of target cells; Mediates the intimate attachment to target host cells. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. Induces membrane fusion in vitro.
Subcellular Localization:
Secreted. Host membrane; Multi-pass membrane protein. Note=Secreted via the type III secretion system 1 (SPI-1 T3SS). Becomes surface exposed upon contact with host cells. Inserted into the host cell membrane.
Domain:
The N-terminal region mediates SPI-1 T3SS-independent secretion. The C-terminal region is necessary for SPI-1 T3SS-mediated secretion. Membrane integration requires both hydrophobic domains and the helical C-terminal region.
Sequence:
MVNDASSISRSGYTQNPRLAEAAFEGVRKNTDFLKAADKAFKDVVATKAGDLKAGTKSGESAINTVGLKPPTDAAREKLSSEGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKEMGIQVSKEFQTALGEAQEATDLYEASIKKTDTAKSVYDAATKKLTQAQNKLQSLDPADPGYAQAEAAVEQAGKEATEAKEALDKATDATVKAGTDAKAKAEKADNILTKFQGTANAASQNQVSQGEQDNLSNVARLTMLMAMFIEIVGKNTEESLQNDLALFNALQEGRQAEMEKKSAEFQEETRKAEETNRIMGCIGKVLGALLTIVSVVAAVFTGGASLALAAVGLAVMVADEIVKAATGVSFIQQALNPIMEHVLKPLMELIGKAITKALEGLGVDKKTAEMAGSIVGAIVAAIAMVAVIVVVAVVGKGAAAKLGNALSKMMGETIKKLVPNVLKQLAQNGSKLFTQGMQRITSGLGNVGSKMGLQTNALSKELVGNTLNKVALGMEVTNTAAQSAGGVAEGVFIKNASEALADFMLARFAMDQIQQWLKQSVEIFGENQKVTAELQKAMSSAVQQNADASRFILRQSRA
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
Subcellular Localization:
Cytoplasm.
Sequence:
MLDLLKISVTGDPSSGKTEACQVFEDLGAYVISADKVSHSFLVPYTSVGQRIIDLLGPEIIIENTLSRKAIAEKVFGNRDLLLSLEEILHPEVCRFVEEKYAHVVQEQKYPLFIAEFPLLYEIQYADWFDQVILISADTGIRKERFLKKTGGSDTSFDLRCARFSSLEEKILRADVVIENNGTKEEFRRKVKQCFKALKGTI
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
MPMQWWLGAESSLLPPSCILAFSASHSLAAAATGTKNPDLAADKALARDFLSNFVGPHGDPKYLSVLQDVANRKIRAVQIELDDPFHHKDVDVVFLLRVIENARRYIDIFADRGHGIGAASITLRNPSMLFIWHIVNGVSNNILNHIILENNENKPVTNSRDTQEICLEQGLHILKIFKDYHVSKTSILNDLASAMGNTPNPYEQAMSTCVNGQAMMLSHMGDLMVVANASDSQVVLGTAFDDGAVTPSSSSST
The following text describes a protein:
Function:
Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate. Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes. Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release. PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MDVRFYPPPAQPAAASDAPCLGPSCLDPYYCNKLQEQRTWSKIYTDQFDGENMYMSMTEPNQDYVPGSQSYPGHSLENEDFNIPPITPPSLPDHTLVSLSETEGGFHSLCHPVNQNGLLPFHPQNMDLPAITVSNMLGQDGSLLANSLSVMQELHNSEGTQYHSQMATMRPRVQPPDIRQSGMMQHGQLTTINQSQLSAQLGLNMGGNNVAHNSPSPPGSKSATPSPSSSVHEDEVDDNSKISGAEKRPAPDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVSKSYSDPIDAKASQPSQMMNAKAPVFHGTAQSHSTLYLNSPYHQQSAISPHLSAMHPGINRSIAPKPSNQMPVTVSLASMAVSPPPSLQMSPPLHQHLHMQQHQPFSMQQSIGNQLQMQGQTSLHSPVMQQGFSLQSEYQNLISPTSTAAQAVTQAMEYVRSGCRNPPGQTVEWNNEYCSNGNMQRDKALYLT
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MDNHTAKDIGMKRSASELALQEYLTTSPLDPCFDLMNRDYTCELRDSLLWSEGLFPAGPFRDAQSSICENLSADSPVSANKPEVRGGVRRTTSGSSHVNSDDEDAETEAGQSEMTNDPNDLKRIRRMNSNRESAKRSRRRKQEYLVDLETQVDSLKGDNSTLYKQLIDATQQFRSAGTNNRVLKSDVETLRVKVKLAEDLVARGSLTSSLNQLLQTHLSPPSHSISSLHYTGNTSPAITVHSDQSLFPGMTLSGQNSSPGLGNVSSEAVSCVSDIWP
The following text describes a protein:
Function:
Upon expression in E.coli has a weak triacylglycerol synthase function, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Also functions weakly as a wax synthase, as it incorporates palmityl alcohol into wax esters in the presence of palmitoyl-CoA.
Sequence:
MSQTARRLGPQDMFFLYSESSTTMMHVGALMPFTPPSGAPPDLLRQLVDESKASEVVEPWSLRLSHPELLYHPTQSWVVDDNFDLDYHVRRSALASPGDERELGIPVSRLHSHALDLRRPPWEVHFIEGLEGGRFAIYIKMHHSLIDGYTGQKMLARSLSTDPHDTTHPLFFNIPTPGRSPADTQDSVGGGLIAGAGNVLDGLGDVVRGLGGLVSGVGSVLGSVAGAGRSTFELTKALVNAQLRSDHEYRNLVGSVQAPHCILNTRISRNRRFATQQYPLDRLKAIGAQYDATINDVALAIIGGGLRRFLDELGELPNKSLIVVLPVNVRPKDDEGGGNAVATILATLGTDVADPVQRLAAVTASTRAAKAQLRSMDKDAILAYSAALMAPYGVQLASTLSGVKPPWPYTFNLCVSNVPGPEDVLYLRGSRMEASYPVSLVAHSQALNVTLQSYAGTLNFGFIGCRDTLPHLQRLAVYTGEALDQLAAADGAAGLGS
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm.
Sequence:
MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF
The following text describes a protein:
Function:
As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
Subcellular Localization:
Nucleus, nucleoplasm. Nucleus speckle.
Sequence:
MSFKRDGDDSSQLNVLKKRRVADLLASYIPEDEALLLKNGSYACTVCHHRPVFNTIDMLSVHRTGKKHLGGLQRYYGKKLEHKNEIQKRRHFDFVRAEDAGEKPPPGPAPLLVQTKRITQNALLKSAPYNSCCSNKKVVANSRNVYDPHSGPSTTTGLNVPLDTQPGPSQPHTSLHSPPTGPCSSPTDEIPPNKNNSRHKKKGEEKFRKEIADPERERNMEHYLQLKSSGWIPDGTGKWVKDENVEFDSDEEEPPALPPS
The following text describes a protein:
Function:
Involved in heme (porphyrin) scavenging. Binds Fe(2+) and Fe(3+) heme but the largest fraction is Fe(2+) heme. Functions as a high-affinity heme binding protein and probably has a role in relaying heme-iron from cell wall-anchored isd proteins receptors to the probable permease IsdF.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MRIIKYLTILVISVVILTSCQSSSSQESTKSGEFRIVPTTVALTMTLDKLDLPIVGKPTSYKTLPNRYKDVPEIGQPMEPNVEAVKKLKPTHVLSVSTIKDEMQPFYKQLNMKGYFYDFDSLKGMQKSITQLGDQFNRKAQAKELNDHLNSVKQKIENKAAKQKKHPKVLILMGVPGSYLVATDKSYIGDLVKIAGGENVIKVKDRQYISSNTENLLNINPDIILRLPHGMPEEVKKMFQKEFKQNDIWKHFKAVKNNHVYDLEEVPFGITANVDADKAMTQLYDLFYKDKK
The following text describes a protein:
Function:
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Sequence:
MKQILYKLFEHQYLGRDEARTILQNIAQGKYNDVQVASLITVFLMRNISVEELCGFRDALLEMRVPVDLSEFAPIDIVGTGGDGKNTFNISTAACFTVAGAGIPVVKHGNYGATSVSGASNVMEQHGVKFTSDVDQMRRSMEQCNIAYLHAPLFNPALKAVAPIRKGLAVRTFFNMLGPLVNPVLPTYQLLGVYNLPLLRLYTYTYQESKTKFAVVHSLDGYDEISLTNEFKVATCGNEKIYTPEGLGFARYQDTDLDGGQTPEDAAKIFDNIMNNTATEAQKNVVVINAAFAIQVVRPEKTIEECIALAKESLESGRALATLKKFIELNNK