lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
[Isoform UL35]: Plays important role in immediate-early gene expression through interaction with UL82. Forms nuclear bodies in host nucleus, independently of PML. In turn, UL35 nuclear bodies associate with and remodel PML bodies. Through interaction with host DCAF1, causes cells to accumulate in the G2 phase of the cell cycle by inducing a DNA damage response. Regulates viral assembly by controlling the localization of the essential gB through regulation of a retrograde transport pathway. This modulation occurs via binding and inhibition of host sorting nexin 5/SNX5. Also plays a role in the inhibition of pattern recognition receptor-mediated type I interferon signaling at the level of TBK1; [Isoform UL35A]: Promotes cytoplasmic UL82 accumulation and inhibits UL35-containing nuclear bodies formation. Regulates viral assembly by controlling the localization of the essential gB through regulation of a retrograde transport pathway. This modulation occurs via binding and inhibition of host sorting nexin 5/SNX5.
Subcellular Localization:
[Isoform UL35]: Virion tegument. Host nucleus. Host cytoplasm. Note=Found in nuclear bodies; [Isoform UL35A]: Host nucleus. Host cytoplasm.
Sequence:
MAQGSRAPSGPPLPVLPVDDWLNFRVDLFGDEHRRLLLEMLTQGCSNFVGLLNFGVPSPVYALEALVDFQVRNAFMKVKPVAQEIIRICILANHYRNSRDVLRDLRTQLDVLYSDPLKTRLLRGLIRLCRAAQTGVKPEDISVHLGADDVTFGVLKRALVRLHRVRDALGLRASPEAEARYPRLTTYNLLFHPPPFTTVEAVDLCAENLSDVTQRRNRPLRCLTSIKRPGSRTLEDALNDMYLLLTLRHLQLRHALELQMMQDWVVERCNRLCDALYFCYTQAPETRQTFVTLVRGLELARQHSSPAFQPMLYNLLQLLTQLHEANVYLCPGYLHFSAYKLLKKIQSVSDARERGEFGDEDEEQENDGEPREAQLDLEADPTAREGELFFFSKNLYGNGEVFRVPEQPSRYLRRRMFVERPETLQIFYNFHEGKITTETYHLQRIYSMMIEGASRQTGLTPKRFMELLDRAPLGQESEPEITEHRDLFADVFRRPVTDAASSSSASSSSSSASPNSVSLPSARSSSTRTTTPASTYTSAGTSSTTGLLLSSSLSGSHGISSADLEQPPRQRRRMVSVTLFSPYSVAYSHHRRHRRRRSPPPAPRGPAHTRFQGPDSMPSTSYGSDVEDPRDDLAENLRHL
The following text describes a protein:
Function:
May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
Sequence:
MKFLGPLENQRLSFLLEKAISREAQMWKVNVPKMPTSQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVEEDERIPVLKVLARDSFCGCSSSEILRMERIILDKLNWDLHTATPLDFLHIFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFKGSMLALAMVSLEMEKLIPDWLPLTIELLQKAQMESSQLIHCRELVAHHLSALQSALPLNSVYVYRPLKHTLVTCDKGVFRLHPSSAPGPDFAKDKSKPEVPVRGTAAFYHHLPAASGCKLTSAKRKVEEMEVDDFYDGIKRLYNEDNAAENVGSVCGADLSRQEGHASPCPPLQPVSVM
The following text describes a protein:
Function:
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
Sequence:
MRRLNRKNNEALKKLNDRQRKVLYCIVREYIENKKPVSSQRVLEVSNIEFSSATIRNDMKKLEYLGYIYQPHTSAGRIPTDKGLRFYYEEMLKISKETSEADLAVETFKSMPLADPEKVLFLAGNLLARLTEGYVLIERPNTRDLKILRVMLIPVSEDYLIFSILTEFGVSKVTPIKTQERLNWEEIERQLNFLLRGRTVGEVLMGKIESLKGSGFLRLIESLIGETVERYLDAGLENLLKDETLTLEDIRNLLEEVKDQKFLESLVGEGITVRIGREIGRKKLEKFAVFSGKYFKGESPIGSVYLFTSKVTKYDRNHRVFEYILNRLSEYFTSTSRR
The following text describes a protein:
Function:
Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).
Subcellular Localization:
Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.
Sequence:
MASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFSGDRGAPKRGSGKVPWLKQSRSPLPSHARSRPGLCHMYKDSHTRTTHYGSLPQKSQRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQKPGFGYGGRASDYKSAHKGFKGAYDAQGTLSKIFKLGGRDSRSGSPMARR
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSRRAEALGALNPQQQQQIIHDEHPRMIGVQNELLETSVSEQLSPLAGFLVRTLNRCGPLTLKALAEAVRQEPFGNPLRSSKGGGASVSGGSVNEAVKQVSSPIPLPVTAPSDIVTDAAIKEIMTRLLLHRVVQHDPSSSTYSVALGYGLFLRTLFPVVVQFFQRNFGETGVTILMVFYQLAVVPWEAALRLATERRPALGEALRHCAREMEKLGLIEFLPDKLPGQAATASPSNAGSGTRVEGPGETVAADACLQELCRLHVPNILFEMLRDAIHRHLLAERFADGSGSNGGGSVASAIVEAFTASARCRRFSERVSGFPAARPPSSASMPLRALLREVPHPEPTVTEVLNRMCRAEGDNIMSCGGGAGVDALEGPYRFRYDAAVEAMQRDCCERMVFARHGVLGVRLIKLLLQHHHMEDRMLAEEAIATLPRTREVLHAMMRDGYVRQQEVPKTSTLTDRLPKNSIFLWGCNMESDLLPTVRLQVAMALRLTITRLAMERNNGVGPGTAMPTPMNIVASATATINGDVHPTGGSYESKHAVAALESSATALMDMMLVLDFY
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MLFRTIRHFDLRRPTLMELVRELRFRTEAPIADCCAALKEANENMDRALEVLRNKGLAKAVKKGSRVTEHGSVVACVGETFGAAIVTVCSETDFAARSLQFQRVCGTVMETLRTQIISTEGTALDDCAAVHRLLTDAAAEQIQATIAVLGENVTIKSIQPLRFAPHVAEHISIGAYTHGTLSVQNVGRVAGVVAVSRTDPSARVPEEKLVDVARHFVACSGAEGSYAHQNFFGTEETVGQWLKRHGLRFSSSLVVDFGKEPIIHTAPQPVAGTK
The following text describes a protein:
Function:
Mitochondrial S-adenosyl-L-methionine/S-adenosyl-L-homocysteine antiporter. Mediates the exchange of cytosolic S-adenosyl-L-methionine, the predominant methyl-group donor for macromolecule methylation processes, for mitochondrial S-adenosylhomocysteine(SAH), a by-product of methylation reactions.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MERPGFTASLVAGGVAGVAVDLILFPLDTIKTRLQSPQGFNKAGGFRGIYAGVPSAAIGSFPNAAAFFITYEYVKWFLHTDSSSYLMPVKHMLAASAGEVVACLIRVPSEVVKQRAQVSASSRTFQIFSNILYTEGIQGLYRGYKSTVLREIPFSLVQFPMWESLKALWSWRQDHVVDCWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKTFCKQVGLFLRVTDLRPRELTCFMLCSRLVPAPLAAMYSLRCTGSGGRRGCQDYLQVSSLERQPSVWEVSSFLVLMSKPAACCWNLAERAPDSGRCPMLCSQERGRRASSCSRQARRSVQQPTWCETEPAVAAQGLGGRGGPTEDLSPPPREPQRRGLGQRGDSTISPRLVRYQHQQPLP
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTPETNNDETLSRPKPRAALPPVPEGMSKSQWKKQWKKEQFELNKPLYAKIRKEKKQKAREQRRERLQKALEENGGEIPEELRRTPRVNVNQKDSGIKVIIDCAFDELMNEKEIVSLSTQITRAYSANKRENHFADVKVTSFNKRLKERFDCGLKGANYDAWKHFEFTDESALPTTNAVYLTADTDETLETLEPGTTYIVGGIVDKNRHKALCYNKAKELGIPTRRLPIGEYIKLCGRKVLTTTHVIQIMLRYFDNHDWKEAFESVLPARKLAELADHAQESNSSSPAEEQDAQDI
The following text describes a protein:
Function:
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Subcellular Localization:
Mitochondrion.
Sequence:
MGHLFSSEAVNMEGKEATYIKGITHDKCVVVFSKTHCPFCHKVKTIFEDFGASYEVVEMDKRSDTSAMQAVLGKMTGASTVPRVFIQGKCVGGYDDTKRLQDSGRLEEMLRDCNAIE
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity).
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane.
Sequence:
MAFAWKKNFSYSKYASICSQTVRQALKPEIKNEVKTHGDAEFLYTRWKNGAQEKTESYNSAKSADKE
The following text describes a protein:
Function:
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of a SNZ isoform.
Sequence:
MTIDRSVTIGVLALQGAFREHIAYFKHLIESNPDEYAVYDFDIKEVRTKEDLELCDSLVIPGGESSSMSYIAERTELLPHLYKFVSDESKSVWGTCAGLIFLSKQLINGIENQRVLGALDIEVSRNAFGRQIDSFEQSLDFSSFIPGCTDFPTVFIRAPVVTKILNQKDSLKEGVIRSNNSYQNQAPVKVLYSLKNYDGKDHELIVAVQQGHILGTSFHPELAEDYRFHKWFLDEFVIKKSKQYIDRII
The following text describes a protein:
Function:
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLNQVPAGKDLPEDIYVVIEIPANADPIKYEIDKETGSLFVDRFMSTAMFYPCNYGYINNTLSLDGDPVDVLVPTPYPLQPGSVIRCRPVGVLKMTDEAGEDAKLVAVPHSKLTKEYDHVKDVQDLPELLKAQIKHFFEHYKDLETGKWVKVDGWEDAAAAKAEILSSFERAKK
The following text describes a protein:
Function:
Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MDLTLLWVLLPLVTVAWGQYGDYGYSYHQYHDYSDDGWVNLNRQGFSYQCPHGQVVVAVRSIFNKKEGSDRQWNYACMPTPQSLGEPTECWWEEINRAGMEWYQTCSNNGLVAGFQSRYFESVLDREWQFYCCRYSKRCPYSCWLTTEYPGHYGEEMDMISYNYDYYMRGATTTFSAVERDRQWKFIMCRMTDYDCEFANV
The following text describes a protein:
Function:
Component of the U3 small nucleolar ribonucleoprotein. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTELINSEPTLFLFPNKEDSKQLVEKAIEVFSNIKIPSTSPIQTIVTKGLDNWQIYNQLALAAKYALDDLPQVDVENEDEEEDSITSFQDEDDETSHQELSDNSEMNNRDDADDEFLGFSGPENLEDVDESSAEDVSGDEAEIMNEEGQQIEQKKDAFGLNDGFFDIDNFNKQTLALEEEAVEEGVLGDEDDGIDLLMDPDENMEDSEDESNGPQADSIMYEDFFGPKTAAGRRELKKKKAESKRKRTSKPDFKNDVQQNVIEENNESSDNEYATFDRVKKDLFASDEEDDVSADQLSSYERDKARLTQQIRELEAENVAKKSWTMMGEATSKGRPSNSLLDVDLEFETGAKPVPVQTEETTETLEDLIKNRIISKTFDDVPKRAPVAVTEFRPSELFELNENKSQRSLAEEYEEEFLKKSNADTYKSEADKKKEKEHEEIKALFSEVSRTLDSLASWHYVPPPPESTVEIVSNAPTLAMEDVQPTAASDTMALAPQEVYKPSNENREGETITRSGIAISSTEMDHQQKQARRRRVRRKHAEKRKQMAEKRRNSGTEQVVRQLSKSNVEVIGKGGERKKVASNSNKYHPIVSSNQLKL
The following text describes a protein:
Function:
N-acetylglutamate synthase involved in arginine biosynthesis.
Miscellaneous:
MISCELLANEOUS: Present with 112 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MWRRIFAHELKYDQPNASSKNLILSVLNTTATKREAKDYLSKYTNDSGQHNHCLFFIRDLHKVAPAILSQFSSVIKRLGMLGLRPMFVIPPSPTHVNIQAELLDSIVTEADLKPLHLKEGLTKSRTGLYHSVFSQESRFFDIGNSNFIPIVKPYVYNEETASEFMTKDVVKFMDCLCQGNIPHIDKFFILNNAGGIPSGERNDNAHVFINLSQELEHLSSSLSHNISTLTKREPRSQNLLHRMEVYVKKDEISSLECEYHDHLENLLLMDKVLSNLAATATGLITTVKAAALSSDRKNPLVYNLLTDRSLISSSLPRFKKKDGEIDSPANMFDDHAWYELPSQQVNAAPSNSDAVLVTTVLKKGVHIKTYDYKTLTQFNSIGLPKKFHVPEKGAKPSSNSPKLDINKFKSIIDQSFKRSLDLHDYIKRINGKIATIIVIGDYEGIAILTYEGSEENSFVYLDKFAVLPHLKGSLGISDIIFNLMFKKFPNEILWRSRKDNVVNKWYFQRSVAVLDLSIDLDPEHCDEKQSQFKLFYYGNPQYAKRALRDKKRLREFMRSVRDIKPSWENEKNIS
The following text describes a protein:
Function:
Catalyzes the reversible transfer of a two-carbon ketol group from fructose-6-phosphate or sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to yield xylulose-5-phosphate and erythrose-4-phosphate or ribose-5-phosphate, respectively. Could act as a stress sensor involved in adaptation process.
Sequence:
MSLLAPPYHGRSQSPPRATLSISFSIMAISSLLFKPHVPLKFSSTKPSLNIKNNTPSSSSLTLYNSLTPDRFHIAKSKTHKLSWQKELKHAFQEPLNNQNLIKTNNNDIDFIDDYDDESFQKLVDRRCVDNVRMLIVDAVQTAKAGHPGMALGMAEVGYYLYRHVMKYNPFNPTWFNRDRFVLSAGHGCLLQYVCLHLAGFESVQLEDLKCLCKLGSRTPGHPENTVTDGIEVPTGPLGQGVANAVGLALAEAHLAARFNKPDCVIVDHRTYCIMGDGCAMEGIAHEAASLAAHWKLHKLTLIYDDNQNTIDGPTSLAFSEDISARFSALGWDTITVDNIHEDMDSFKNALLSAVNETNKPTFIRVKTLIGRLSKKEGTSKAHHGTFDEDDTKEMKQKVKWNNQDPFHVIPMVYSEMQTQTCHSEKLEMEWLSNIRYYKSKYPQEAAEFEVLLHGGLPSKWESCLPKWSVSDPVDATRGYSEKCLNRLAKVVPGLIGGSADLASSNKVYLHDYQDFAPPHSAWGRNIRYGIREHAMAGISNGIALHGSGLIPFAATFLIFSDYMKNSIRLSGLGHAGVIYIMTHDSIGLGEDGPTHQPVEQLAGLRAVPGLLVFRPGDGNETAGAYKVAIANRDVPSVIALSRQKVAANLEGTSTNEVERGGYIISDNSGKSLPDIILMGTGSELCLCEGSAKILRNEGRKVRVVSLVCWRLFDKQPPEYKEHVLPSSVTKRVSVEAGSPLGWREYVGGVGVVIGVEEFGASGAYLDTFKKFGFTEENVTKVAKSLLDH
The following text describes a protein:
Function:
Has a role in vesicular trafficking and septation during cytokinesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MKKKEIKQLKNEIKIALLNSDVETLSHIGKEGHGFLMKSLRKSVWVSLCGLSCRHRMECLSRSTSQSSYADQNQVHLDSERSFFQYKLNPFLLRKHRSQLTKLLSVVFKHYPELCYYQGLHDIAQILLLTLPFSHALPLMEHLVFYRLRDFMLPTLDGTVKQLQLILAVIKARDPTLYEYLIKADIQCYFALSWLITWFAHDVSDISVVCRLFDFFISSHPLTVVYTCAQVVLDNRTSIIELLWDNSGADLLHSYLCKLPASINVNQLIKNTCATISAVPFSSLPLDRYQISPYSCLRNTGDPWEYMSRSNGLLLFRLQLAELQEEKHKPGTKVPAVFLQENIFNGCNMLAAITVIGIGIVASQLIPKSTSNS
The following text describes a protein:
Function:
May play a role in protection or detoxification.
Subcellular Localization:
Secreted.
Sequence:
MKPLYVVFGLWLLIGCFLSGECHRGPRGQRDPRKPLAPSTHHPHSRHTQPDPKHGQFGLPPFLPMSSGFGKTSSFTLYSPSFEVKVQPPSYTVHILGSILGQMRAISPQRNSPARPPPTVKANTIPETIAE
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the YhaV toxin and neutralizes its ribonuclease activity. Also acts as a transcription factor. The YhaV/PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression; Negatively regulates its own expression as well as relieving the export block imposed by high-level synthesis of the LamB-LacZ hybrid protein. Overexpression leads to increased doubling time and also suppresses a htrA (degP) null phenotype.
Subcellular Localization:
Cytoplasm.
Sequence:
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNNPQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
The following text describes a protein:
Function:
Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).
Miscellaneous:
MISCELLANEOUS: Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist.
Subcellular Localization:
Membrane; Lipid-anchor.
Sequence:
MSDMGGLKNLVANTDYLKAQSLDEKEIKKRRCSLGLPHLGNCTDVRVSVSKGFEDICEQQPIGRACFRQFLSVSSPEYLAAAELLDELNCWNLAEAEAKEEARLNIINKFCKADSKSFLAFLTEDEAEKCKAVSEKDFEEVMMGQVKEATQKFLRGQPFEEYQTSLFFDRFVQWKKFEKQPITDKYFYEFRTLGKGGFGEVCGVQVKTTGQMYACKKLDKKRLKKKSGEKMALLEKKILEMVNSLFIVNLAYAFDTKTHLCLVMTLMSGGDLKYHIFHVGEVGIEMERIIHYTAQITSGILHLHSMDIVYRDMKPENVLLDCQGQCRLSDLGLAVELPNGKTTTQKAGTKGYMAPEILKQEPYRTSVDWWALGCSIYEMVAGRVPFRDHKEKVAKEELLRRTLEDEVKFEHRNFDAPSKDIISLFLKRNIEDRLGSNDDPRKHEFFKSINFPRLEAGLIPPPWEPKANVVYAKDTGDIREFSDVKGVKFDANDEKFFKEFSTGVVPIAWQQEMIDSGLFDELSDPNRKESAAGLEDEEQQKSKSCTLL
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MAASSSREAMNKQLLDFIHSMEQEGLVDYRFAKVHMLKESSGPFFFASLLPTFCHDSTATLRDLTVALGQPLLNYHDLGELCFKIKGGAACLGVCRMAHACGQLHQAVQNRATKESLITALNAAKQEFSIMQEKLETLVQLETKIVSNETDCP
The following text describes a protein:
Function:
Adapter protein for the cul3 E3 ubiquitin-protein ligase complex (By similarity). Involved in late neuronal development and muscle formation (By similarity).
Subcellular Localization:
Cytoplasm. Note=Found in punctated bodies in the cytoplasm.
Sequence:
MLLPLACLHGRVAQCLTSLLLLAEPLPRPRRGARARGAASTGAEAAPAAPPAKMAAELYAPASAAAADLANSNAGAAVGRKAGPRSPPSAPAPAPPPPAPAPPTLGNNHQESPGWRCCRPTLRERNALMFNNELMADVHFVVGPPGATRTVPAHKYVLAVGSSVFYAMFYGDLAEVKSEIHIPDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAKACVNFLETSLEAKNACVLLSQSRLFEEPELTQRCWEVIDAQAEMALRSEGFCEIDRQTLEIIVTREALNTKEAVVFEAVLNWAEAECKRQGLPITPRNKRHVLGRALYLVRIPTMTLEEFANGAAQSDILTLEETHSIFLWYTATNKPRLDFPLTKRKGLAPQRCHRFQSSAYRSNQWRYRGRCDSIQFAVDRRVFIAGLGLYGSSSGKAEYSVKIELKRLGVVLAQNLTKFMSDGSSNTFPVWFEHPVQVEQDTFYTASAVLDGSELSYFGQEGMTEVQCGKVAFQFQCSSDSTNGTGVQGGQIPELIFYA
The following text describes a protein:
Function:
Binds DNA at low salt concentrations.
Domain:
Contains an unusual winged helix-turn-helix (wHTH) DNA-binding motif missing the typical third helix.
Sequence:
MPGRAPGSTLARVGSIPAGDDVLDPDEPTYDLPRVAELLGVPVSKVAQQLREGHLVAVRRAGGVVIPQVFFTNSGQVVKSLPGLLTILHDGGYRDTEIMRWLFTPDPSLTITRDGSRDAVSNARPVDALHAHQAREVVRRAQAMAY
The following text describes a protein:
Function:
Part of a cation efflux system that mediates resistance to copper and silver.
Miscellaneous:
MISCELLANEOUS: The cus system plays an important role in copper tolerance under anaerobic growth and, under extreme copper stress, in aerobic growth.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MIEWIIRRSVANRFLVLMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVSAELGPDATGVGWIYEYALVDRSGKHDLADLRSLQDWFLKYELKTIPDVAEVASVGGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSIELAEAEYMVRASGYLQTLDDFNHIVLKASENGVPVYLRDVAKVQIGPEMRRGIAELNGEGEVAGGVVILRSGKNAREVIAAVKDKLETLKSSLPEGVEIVTTYDRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWQHQHPDATLDNKTRWQVITDASVEVGPALFISLLIITLSFIPIFTLEGQEGRLFGPLAFTKTYAMAGAALLAIVVIPILMGYWIRGKIPPESSNPLNRFLIRVYHPLLLKVLHWPKTTLLVAALSVLTVLWPLNKVGGEFLPQINEGDLLYMPSTLPGISAAEAASMLQKTDKLIMSVPEVARVFGKTGKAETATDSAPLEMVETTIQLKPQEQWRPGMTMDKIIEELDNTVRLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLADIDAMAEQIEEVARTVPGVASALAERLEGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRDSPQALRQLPILTPMKQQITLADVADIKVSTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQKAIAEKVQLKPGTSVAFSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGVAAEFGVVMLMYLRHAIEAVPSLNNPQTFSEQKLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAYKLMWLHRHRVRK
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MADKRSCLVRLTGTRMSQKSDANSYPDGYRVLNSCELRELLQDEDKMNQIVRLSEKFQELQMDRDTLLVTNRSLAEDSLTRRPHLQNGKLQLAAKYEELATLSTACREKQSRLEAFTEKHSPQTAHNLLQEEVTRAEEQSEELLERFMEGHVPLEEFLDCFQSHRKTYHIRRAQAEKLQELNRPGRKAKKQEEEQHKREDQLKESHSNGISGPPRVFQLRYGLTPAILLPLSSSSASILDSRSGQPQGSGPSAPHSCPGQPVGLRVIGQLPGWPVRPVRLQQLYRPSPHQPEPPCR
The following text describes a protein:
Function:
Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral OPG148/A20 and OPG116/D4 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform OPG116/D4synthesis across an abasic site.
Miscellaneous:
MISCELLANEOUS: Ts42 is a temperature-sensitive mutant. PAArVg is a mutant resistant to the drug phosphonoacetic acid (PAA). NG26 is a double mutant with a temperature-sensitive lesion and a mutation rendering the virus resistant to PAA.
Sequence:
MDVRCINWFESHGENRFLYLKSRCRNGETVFIRFPHYFYYVVTDEIYQSLSPPPFNARPLGKMRTIDIDETISYNLDIKDRKCSVADMWLIEEPKKRSIQNATMDEFLNISWFYISNGISPDGCYSLDEQYLTKINNGCYHCDDPRNCFAKKIPRFDIPRSYLFLDIECHFDKKFPSVFINPISHTSYCYIDLSGKRLLFTLINEEMLTEQEIQEAVDRGCLRIQSLMEMDYERELVLCSEIVLLRIAKQLLELTFDYVVTFNGHNFDLRYITNRLELLTGEKIIFRSPDKKEAVYLCIYERNQSSHKGVGGMANTTFHVNNNNGTIFFDLYSFIQKSEKLDSYKLDSISKNAFSCMGKVLNRGVREMTFIGDDTTDAKGKAAAFAKVLTTGNYVTVDEDIICKVIRKDIWENGFKVVLLCPTLPNDTYKLSFGKDDVDLAQMYKDYNLNIALDMARYCIHDACLCQYLWEYYGVETKTDAGASTYVLPQSMVFEYRASTVIKGPLLKLLLETKTILVRSETKQKFPYEGGKVFAPKQKMFSNNVLIFDYNSLYPNVCIFGNLSPETLVGVVVSTNRLEEEINNQLLLQKYPPPRYITVHCEPRLPNLISEIAIFDRSIEGTIPRLLRTFLAERARYKKMLKQATSSTEKAIYDSMQYTYKIVANSVYGLMGFRNSALYSYASAKSCTSIGRRMILYLESVLNGAELSNGMLRFANPLSNPFYMDDRDINPIVKTSLPIDYRFRFRSVYGDTDSVFTEIDSQDVDKSIEIAKELERLINNRVLFNNFKIEFEAVYKNLIMQSKKKYTTMKYSASSNSKSVPERINKGTSETRRDVSKFHKNMIKTYKTRLSEMLSEGRMNSNQVCIDILRSLETDLRSEFDSRSSPLELFMLSRMHHSNYKSADNPNMYLVTEYNKNNPETIELGERYYFAYICPANVPWTKKLVNIKTYETIIDRSFKLGSDQRIFYEVYFKRLTSEIVNLLDNKVLCISFFERMFGSKPTFYEA
The following text describes a protein:
Function:
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
Subcellular Localization:
Cytoplasm.
Sequence:
MSAPAQPAPGVDGGDPSQARIRVPAGTTAATAVGEAGLPRRGTPDAIVVVRDADGNLRDLSWVPDVDTDITPVAANTDDGRSVIRHSTAHVLAQAVQELFPQAKLGIGPPITDGFYYDFDVPEPFTPEDLAALEKRMRQIVKEGQLFDRRVYESTEQARAELANEPYKLELVDDKSGDAEIMEVGGDELTAYDNLNPRTRERVWGDLCRGPHIPTTKHIPAFKLTRSSAAYWRGDQKNASLQRIYGTAWESQEALDRHLEFIEEAQRRDHRKLGVELDLFSFPDEIGSGLAVFHPKGGIVRRELEDYSRRKHTEAGYQFVNSPHITKAQLFHTSGHLDWYADGMFPPMHIDAEYNADGSLRKPGQDYYLKPMNCPMHCLIFRARGRSYRELPLRLFEFGTVYRYEKSGVVHGLTRVRGLTMDDAHIFCTRDQMRDELRSLLRFVLDLLADYGLTDFYLELSTKDPEKFVGAEEVWEEATTVLAEVGAESGLELVPDPGGAAFYGPKISVQVKDALGRTWQMSTIQLDFNFPERFGLEYTAADGTRHRPVMIHRALFGSIERFFGILTEHYAGAFPAWLAPVQVVGIPVADEHVAYLEEVATQLKSHGVRAEVDASDDRMAKKIVHHTNHKVPFMVLAGDRDVAAGAVSFRFGDRTQINGVARDDAVAAIVAWIADRENAVPTAELVKVAGRE
The following text describes a protein:
Function:
Part of an energy-coupled inorganic carbon pump.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSELSPQWLLVSLYLGGLVLSLWLPQQQWRIAKFATLAGFIAMLGNTLFAIGQASINLVPVDGLGIVMAILVSLLGWVITRFAHRYLQGEAQQARFVTATLFTLSCVALLVTSQHLLVIVLAWSGTSVGLHRLLTFYPERKAARVVAHKKFLVSRFAEICLLLALGLIYLDVGSLSLQEIHFALNAQDSLPLSLTGAALLLAFAAILKTAQLPLHGWLIQVMEAPTPVSALLHAGVVNMGGFVLLRVAELIGLVPSAQWLLVIVGSLTAVLAGMVMLTRISIKVRLAWSTCAQMGFMLMEIGLGLYELALLHLVAHSLYKAYAFLSSGEAVERARLHDFQAPQSVNGKAVGALLAVGLSAALILILHHLWQSLTSNLHLPNAVVAILALGFAPLLWQSGRFTPSGLSLGVLRVALLTQLYFVWHLLFAGLAPELRPASPLALSFVMFCFITLYLMQVLLCLYPKSRLSLWLYPWVYHGFYLDETFTRLTFKYWPVQLTLPTALSSTQAQPTTGERV
The following text describes a protein:
Function:
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
Subcellular Localization:
Nucleus. Mitochondrion.
Sequence:
MAPIPDLEDTWEKIETMRAEYVCPVDVFGAHMLSDTTETPDGRFRFAIGLLLSARNLDRVTAAAMYKLNHMLPVPPDGLDKERLKKLEAEFEEKTKGLQKSTKAEAMLKKNFPIDIDNLMKLDAWRLTAKNVVDSGLDELGRIIHPVGFCRRKAEYMKNVAQICLDNYGGDIPKDLAGILKLPGFGPKMGHLLVQIVYGQVEGIAVDTHVCRIAQRLRWVEKGMCEPNGKMLNPDDVAKQLVETLPKDKWRDINHLLVGFGQTVCKASFPECNRCLIAGTGHCYHKSETKPETGTGKPRNRERRAKASKREAEDQGGATDEDE