lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.
Subcellular Localization:
Nucleus.
Sequence:
MAVHAPYNHAPPPTQEINGQKPTLAPAITLERPADCINRGQYPAFYIICGYLNRLRADAPHKKYELLTRIFGNWREKVGPDLYPLIRLLLPDKDRERPVYNLKESMLARCYIDILSLEKHSEAAQRLIKWKQPAGNSPNPTGDFAKVCYNEIKARSTVEEGQLSVEAVNMLLDKLAVGKMKQKDYVPILKAINMQCTAEEQEWIIRIILKDLHISIRERGVLSAFHPDAIDLYNVCSDLKRVCWTLYDPGFRLNKNETHLELFHSFLPQLCGRMNDASLENIAKAIGAPKEFIMEEKLDGERIQLHMRGNGAQWFYCSRKAKDYTYLYGAHPGEGSLTRYIATAFQDNVRNVILDGEMMVWDPVVERYLAFGTLKSAALAFSLVKVFDILFLNDHCLSRKRLSERKRLLRSGKIFKNIENYKGRLEFVDEKRGKNAKDIREYLERVVETKGEGLVVKKTDVIYQTNSRGYDWIKVKPEYSDQMGENLEVLVLGGWWGKGGRSGKISRLLCGLREQAFDDGTLQDFLFNRFWNELLGLRVDFVSHLMHLRSMRCSPTHLSQCRNKHKKHWRPFDRSNPPPFMKLGPVGLDDKPDVYIEPENSFVIEVKASEIVPAGYGIGFTLRFPRCKYIYYDKNSRDYALDDECLWTVGQGFFYKTRKLIKRTDFMDLFSRPKRSYDDSQGPGNFRGQKLSDADVETSIFSDMTFSDLEALVHKHGADFTQAQLSDLSAIVISPDQKNPLVRAQIRHGVNVIKPEWVFESIARRTALPFLKEFLVFASEEAQDGRYYNKTLEQYDKVSFVRDRTGGALVDEDGDADVEDEIMDGEDKDEIDVEESRESKNRRMAREDLKEKESNRTLEQKKLQEAWGLRSRASPGDSDSEPEEEMSLKEESDTDSERSRGLRAIYEDEEDGENDSHESDVGVNGDDYRAVPLSGLNDKEEGLMGESPEAMHYDEDRIFYHLAFYIDTAKNAAVNGLESSSPSFDTQERLVKVEKLLIENGGRVARSISDPKLTHIIMDDEDSRRYVELTRKTAMPKRKHIVTPKWVEDCVDEETLLDEDLYKPK
The following text describes a protein:
Function:
RNA helicase.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MMSSMNFGALPLSEPTKNAIAEIGFTNMTEIQSRSIPELLKGRDVLGAARTGSGKTLAFLVPAVELLYHARFMPRNGTGVLIISPTRELAMQIYGVARKLMKHHSQTHGIVMGGVKRNVEAEALKKGVNLLVSTPGRLLDHLQNTKGFLFKNLQCLVIDEADRILEIGFEEDMKQIIKLLPKERQTVLFSATQTTKVEDLAKLSFKKAPIYIGVDDERSKATVEGLEQGYCVVKTDKRFLLLFTFLKKNLKKKVMVFFSSCNSVKFHGELLNFIDIPCLDIHGKQKQQKRTNTYFEFCNAEKGILLCTDVAARGLDIPAVDWIIQYDPPDDPKEYIHRVGRTARGESGRGRALLFLTPEELGFKRYLTMAKVPLNEYMFPENKIANVQSQLENLIGKNYNLHRSARDAYRSYIMAYNSHAMKDAFNVHRLDLQAVAASFGFSCPPKINNLSIDSSAAKFRKQGKERKSSGHKFGASNPYGKRGEDDKRQFSKF
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Sequence:
MLLSHNPEMTHTRTTATSWTLLSLRPSGEHAPLRRAVARHGGQLLAVSPWRLQINDTLQARDALRQALGAPIVVFTSPAAVHAAHRLLPLQRPGPAQWASVGEGTARALQACGIDAVVRPARMDSEGLLALPVFDAPLHAVGLITAPGGRGTLSPALEQRGAQILRADVYQRVALRLRASTLHALESALPRSVMALSSSEALTLIVQQLPPSLATALKTRPVVASSDRMLEAARAAGFVQVHRSEGPLPAQLAAAAAAIMTPPPPC
The following text describes a protein:
Function:
Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress (By similarity).
Subcellular Localization:
Cell tip. Cytoplasm, cytoskeleton, actin patch.
Sequence:
MSLETYKFSDELHDDFKVVDSWINNGAKWLEDIQLYYKERSSIEKEYAQKLASLSNKYGEKKSRKSSALSVGDTPAMSAGSLECASLTTWSKILDELTRSSKTHQKLSDDYSLDIAEKLKKLESHIEALRKVYDDLYKKFSSEKETLLNSVKRAKVSYHEACDDLESARQKNDKYREQKTQRNLKLSESDMLDKKNKYLLRMLVYNAHKQKFYNETLPTLLNHMQVLNEYRVSNLNEIWCNSFSIEKSLHDTLSQRTVEIQSEIAKNEPVLDSAMFGRHNSKNWALPADLHFEPSPIWHDTDALVVDGSCKNYLRNLLVHSKNDLGKQKGELVSLDSQLEGLRVDDPNSANQSFESKKASINLEGKELMVKARIEDLEVRINKITSVANNLEEGGRFHDFKHVSFKLPTSCSYCREIIWGLSKRGCVCKNCGFKCHARCELLVPANCKNGEPEVADDDAVDTSVTATDDFDASASSSNAYESYRNTYTDDMDSSSIYQTSLSNVKTEETTPAEPASKVDGVVLYDFTGEHEGVITASEGQEFTLLEPDDGSGWVRVKIDGTDGLIPASYVKLNDELNTSVTLDGDSSYVKALYAYTAQSDMELSIQEGDIIQVTNRNAGNGWSEGILNGVTGQFPANYVTDV
The following text describes a protein:
Function:
Probable methyltransferase required to silence rDNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSRPRSISMKHGSVTKRLAGSRFRVLNEAFYTESSLQTQERLRMNPAEFVDYHKGYQEQVSKWEVNPIALFIDLLERVLAGDAEGGDGSAATVGTPSANSAGIGLLDAELVQNLQDLDVRHSAKPSKANKHQIFPSFTGLTRDDIKTIGDMGCGKAALAQAIVPKYSPGVAVHSFDLVALNSFVTVANIRALPLEPHRLDLAIYCLSLMGSDYVSFIKEAFRVVRPGGELWLAEVNSRITNTKHLIELFSACSFRKIKVIPFTHFTLISFRRLEDLEEGHPSEKKRADITKYEKCLTPCTYKKR
The following text describes a protein:
Function:
Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Rough endoplasmic reticulum. Endosome, multivesicular body. Cytoplasm, perinuclear region. Note=Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells (By similarity).
Sequence:
MKNPMLEVVSLLLEKLLLISNFTLFSSGAAGEDKGRNSFYETSSFHRGDVLEVPRTHLTHYGIYLGDNRVAHMMPDILLALTDDMGRTQKVVSNKRLILGVIVKVASIRVDTVEDFAYGANILVNHLDESLQKKALLNEEVARRAEKLLGFTPYSLLWNNCEHFVTYCRYGTPISPQSDKFCETVKIIIRDQRSVLASAVLGLASIVCTGLVSYTTLPAIFIPFFLWMAG
The following text describes a protein:
Function:
Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism (By similarity). Regulates suberin accumulation in roots.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MAGQKILSLLVIALVVTFAAAARLLDEENAFSATTTTLGSGSGSTGIGFGAGTGSSGSGSTGFGFGAGSGSSGSGSTGSGLGAGTGSIPSSGSGPGLLPTASSVPGSLAGGGSGSLPTTGSATGAGAGTGSALGGGPGAGSALGGGAGAGPALGGGAGAGPALGGGAGAGSALGGGGAGAGPALGGGGAGAGPALGGGVAGSGSALGGGASAGPDNTLVFFMHDILGGSNPTARAVTGVVANPALSGQLPFAKPNGANLPVSNGVPSNNNNNGIVNNNNVPFLVGLGGTTANILQNNNNGNNILNGFPVASGGQLPSGSALQMLMFGTMTVIDDELTEGHELGSGLLGKAQGYYVASAIDGTSQTMAFTAMFESGGYEDSISFFGVLRTAVSESHIGVMGGTGKYVNARGFAILKTFTGSSGTQQNQPHQFTDGLETVVECTVYLSY
The following text describes a protein:
Function:
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEQGMVNAAGFSYIASESTQSTILCCQCGVPIPQNPAAMCLDCIKMSTDITEGIPRDGMLSYCRECERYLQPPNVWVAAQLESRELMAICLKKLRGLNQVRLIDASFIWTEPHSRRVKVKLTVQKEAFTNTILQQSMVVEYVVNYTQCPDCARTYTPHIWKACVQVRQKVLHKRTFLYLEQVILKNRAHLNTVNIKEAKDGIDFFTLSSSEELISKDIKSNTAHYKFTYSIEIVPICKDDLVCLPKPLAKAHGNISQLLLCTKVGTTIHFIDPLTLQTCEMLPTTYWHMPFPSLADIGELSEFIVADVDFLGPTNGKNVLADVELIKSSDGSTHMARTHLGALLSAGNTVLCYHMAITNFNNEIFDALKDNLIPDVIIVKKTYSNPKRRKNRFWKLKSIGIDQGELEPKKQDLERQERDYELFLRNLEEDPELRQNINLYKNDAYRPPADNEMEEDDEEIDDEEVPAISVDELLDDVESMHIADE
The following text describes a protein:
Function:
Multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and regulation of viral and cellular gene expression. Regulates the nuclear localization of viral envelopment factors UL34 and UL31, by phosphorylating the US3 kinase, indicating a role in nuclear egress. Disrupts host nuclear lamins, including LMNA and LMNB1. Phosphorylates the viral Fc receptor composed of glycoproteins E (gE) and I (gI). Phosphorylation of glycoprotein E (gE) by UL13 alters its subcellular localization, from the host early endosome to the plasma membrane. Participates in the transcriptional regulation of cellular and viral mRNAs mainly by phosphorylating the viral transcriptional regulator ICP22. Additional substrates have been identified, including UL41, UL49 or host EF1D.
Miscellaneous:
MISCELLANEOUS: Displays a substrate specificity similar to host CDC2.
Subcellular Localization:
Virion tegument. Host nucleus.
Sequence:
MDESRRQRPAGHVAANLSPQGARQRSFKDWLASYVHSNPHGASGRPSGPSLQDAAVSRSSHGSRHRSGLRERLRAGLSRWRMSRSSHRRASPETPGTAAKLNRPPLRRSQAALTAPPSSPSHILTLTRIRKLCSPVFAINPALHYTTLEIPGARSFGGSGGYGDVQLIREHKLAVKTIKEKEWFAVELIATLLVGECVLRAGRTHNIRGFIAPLGFSLQQRQIVFPAYDMDLGKYIGQLASLRTTNPSVSTALHQCFTELARAVVFLNTTCGISHLDIKCANILVMLRSDAVSLRRAVLADFSLVTLNSNSTIARGQFCLQEPDLKSPRMFGMPTALTTANFHTLVGHGYNQPPELLVKYLNNERAEFTNHRLKHDVGLAVDLYALGQTLLELVVSVYVAPSLGVPVTRFPGYQYFNNQLSPDFALALLAYRCVLHPALFVNSAETNTHGLAYDVPEGIRRHLRNPKIRRAFTDRCINYQHTHKAILSSVALPPELKPLLVLVSRLCHTNPCARHALS
The following text describes a protein:
Function:
Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP).
Miscellaneous:
MISCELLANEOUS: The genes bscA, bcsB, bcsZ and bcsC are constitutively transcribed but cellulose synthesis occurs only when DgcC, a putative transmembrane protein regulated by CsgD, is expressed. Cellulose production is abolished in E.coli K12.
Subcellular Localization:
Cell inner membrane; Single-pass type I membrane protein.
Sequence:
MKRKLFWICAVAMGMSAFPSFMTQATPATQPLINAEPAVAAQTEQNPQVGQVMPGVQGADAPVVAQNGPSRDVKLTFAQIAPPPGSMVLRGINPNGSIEFGMRSDEVVTKAMLNLEYTPSPSLLPVQSQLKVYLNDELMGVLPVTKEQLGKKTLAQMPINPLFISDFNRVRLEFVGHYQDVCEKPASTTLWLDVGRSSGLDLTYQTLNVKNDLSHFPVPFFDPSDNRTNTLPMVFAGAPDVGLQQASAIVASWFGSRSGWRGQNFPVLYNQLPDRNAIVFATNDKRPDFLRDHPAVKAPVIEMINHPQNPYVKLLVVFGRDDKDLLQAAKGIAQGNILFRGESVVVNEVKPLLPRKPYDAPNWVRTDRPVTFGELKTYEEQLQSSGLEPAAINVSLNLPPDLYLMRSTGIDMDINYRYTMPPVKDSSRMDISLNNQFLQSFNLSSKQEANRLLLRIPVLQGLLDGKTDVSIPALKLGATNQLRFDFEYMNPMPGGSVDNCITFQPVQNHVVIGDDSTIDFSKYYHFIPMPDLRAFANAGFPFSRMADLSQTITVMPKAPNEAQMETLLNTVGFIGAQTGFPAINLTVTDDGSTIQGKDADIMIIGGIPDKLKDDKQIDLLVQATESWVKTPMRQTPFPGIVPDESDRAAETRSTLTSSGAMAAVIGFQSPYNDQRSVIALLADSPRGYEMLNDAVNDSGKRATMFGSVAVIRESGINSLRVGDVYYVGHLPWFERVWYALANHPILLAVLAAISVILLAWVLWRLLRIISRRRLNPDNE
The following text describes a protein:
Function:
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 396 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Domain:
The HIT domain is required for enzymatic activity.
Sequence:
MSWRYALKNYVTSPETVNDDTVTYFDDKVSIIRDSFPKSECHLLILPRTMQLSRSHPTKVIDAKFKNEFESYVNSAIDHIFRHFQEKFRIKKSDDDKDPCWDDILKDKNKFVRNFVQVGIHSVPSMANLHIHVISKDFHSVRLKNKKHYNSFNTGFFISWDDLPLNGKNLGTDKEIETTYLKEHDLLCCYCQRNFSNKFSLLKKHLELEFNSHFELK
The following text describes a protein:
Function:
Plays a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MRRLNRKKTLSLVKELDAFPKVPESYVETSASGGTVSLIAFTTMALLTIMEFSVYQDTWMKYEYEVDKDFSSKLRINIDITVAMKCQYVGADVLDLAETMVASADGLVYEPTVFDLSPQQKEWQRMLQLIQSRLQEEHSLQDVIFKSAFKSTSTALPPREDDSSQSPNACRIHGH
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGDGGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTDLVPKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYTPSQQGVAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVKEQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKAREAVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKEDGEARERDEIRHDRRKERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSNEVQYDQRLFNQSKGMDSGFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRCQAIQLNFSVYTGESKVVHSFFSFSLDLFPTRSFLVQTVDREAEKDQCSLRKILLVWTSFWKKPNSMVALKDPQIAAAPRNTSMKARRGGRNRHRSLQSE
The following text describes a protein:
Function:
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses. Also inhibits host IFN-alpha-stimulated STAT2 nuclear translocation and interferon-stimulated response element transcriptional activity by interacting with and inhibiting host TYK2. Induces SUMO expression during viral latency thereby dysregulating the host sumoylation processes.
Subcellular Localization:
Host cell membrane; Multi-pass membrane protein.
Domain:
Two regions, C-terminal-activating region 1 (CTAR1) and CTAR2, have been identified within the cytoplasmic carboxy terminal domain that activates NF-kappa-B.
Sequence:
MEHDLERGPPGPRRPPRGPPLSSSLGLALLLLLLALLFWLYIVMSDWTGGALLVLYSFALMLIIIILIIFIFRRDLLCPLGALCILLLMITLLLIALWNLHGQALFLGIVLFIFGCLLVLGIWIYLLEMLWRLGATIWQLLAFFLAFFLDLILLIIALYLQQNWWTLLVDLLWLLLFLAILIWMYYHGQRHSDEHHHDDSLPHPQQATDDSGHESDSNSNEGRHHLLVSGAGDGPPLCSQNLGAPGGGPDNGPQDPDNTDDNGPQDPDNTDDNGPHDPLPQDPDNTDDNGPQDPDNTDDNGPHDPLPHSPSDSAGNDGGPPQLTEEVENKGGDQGPPLMTDGGGGHSHDSGHGGGDPHLPTLLLGSSGSGGDDDDPHGPVQLSYYD
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (By similarity). Essential for pollen-tube discharge that take place only in the presence of functional peroxisomes in either the male or the female gametophyte.
Subcellular Localization:
Peroxisome membrane; Peripheral membrane protein.
Sequence:
MASQPAGGSPPKPWEKEGNTSGPNPFRPPSNTSTAGSVEASGTANPGEVVPPPVNRPNTAANMNSLSRPVPARPWEQQNYGSTMGGGYGSNLGMTSGYGSGTYGSALGGYGSSYGGGMYGGSSMYRGGYGGGGLYGSSGMYGGGAMGGYGGTMGGYGMGMGTGMGMGMGMGMGGPYGSQDPNDPFNQPPSPPGFWISFLRVMQGAVNFFGRVAMLIDQNTQAFHMFMSALLQLFDRGGMLYGELARFVLRMLGVRTRPRKMQQPPQGPNGLPLPHQPHGNQNYLEGPKTAAPGGGGGWDNVWGN
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Sequence:
MYTMYASVNIGTPIVLCQDTSNLLEGAPPYCAFWQDTNNPSGCLLHRTGSLWPPRSTRCGLDGASIIIRASPPYRRQSPTHPLTQDPPKLPKAAAAMAAQTFLLAPPAALFAAPSSSARPFHSLRLVAGPGGAAAARALVLADATKKAVAVLKGTSEVEGVVTLTQDDEGPTTVNVRVTGLTPGLHGFHLHEFGDTTNGCISTGPHFNPNNLTHGAPEDEVRHAGDLGNIVANTEGVAEATIVDSQIPLSGPNSVVGRAFVVHELEDDLGKGGHELSLTTGNAGGRLACGVVGLTPL
The following text describes a protein:
Function:
Cleaves the sulfated polysaccharide porphyran at the (1->4) linkages between beta-D-galactopyranose and alpha-L-galactopyranose-6-sulfate, forming mostly the disaccharide alpha-L-galactopyranose-6-sulfate-(1->3)-beta-D-galactose. Some longer oligosaccharides of even number of residues are also observed. Inactive on the non-sulfated agarose portion of the porphyran backbone. In contrast to PorA, tolerates the presence of 3-6-anhydro-L-galactose in subsite -2.
Subcellular Localization:
Periplasm.
Sequence:
MKLSNQFLITITLLITSITFAQEAPHFKPGEDPRQPHQEWKLIENMSDEFEGKKIDEKKWQISGQGWIGRAPGLFLAENISLNNGSLQITTTMLPEPIVKNNKTYTHGGGYVGSRNGMTYGYYECEMKANKTFMSSTFWLINEGKDRLGCDKRTTELDIQESVGQITNDADWMKYFDQTMNSNTHSRNIPEGCEYEKGSSKGKAELGGKAYEDFHVYGVWWKSKDEIIFFLDGKMQSKVTPPADFDIEMYLRMVVETYDWNPVPKDGGMTGSKEDRTTTYNWVRSWQLVDSKN
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MQCLESFIDNKLPFAIASGGNAVKWELRLLNGLGSLVQEHYVVENAEKLGLPNTSRTHEEVINQCIICLLDRRLFNNVLTYGYRLANEPELSSRLHCLYTNTSSSTLRTGLWQMLHEAIGTANFTHLLVNCSIFRYDGRYFHQVTGNALNEPHKPPIWWLRREGLLLQGELATREDIDNTGFMYRNLGIIKWRGLLPDDIEELAAEVFGELPTDMVMLRGLMAKMARNYSRVKFRRIIDCICPRRSVQAAGSNEELKSDLKLVTRLILVLVDKIVPLELFGSKRNKAKLFKRISELLALNLNSRMPFAYVITGINTNDIMWDAGSCSNRQIYFEDFVYWLVRTFIPRLVGSIFYCSELSSQVTTVYIRQDVWREISRPFLNWYFQVYLHENKDCSAHGSFVASDYNHRYLRLIPKRHKGQFRVLAIPCKGIDEEDKREYEDYVRTVIKPVQQILEYLRMRRAVRFQRLYSPAQIAKYIGEFRSSILTKHKVIPPLFVLKFDIASCYDSIPMIKVTEVVQKLMKDETCFYLRKMLIYDTKHHIIKRKSAVNGNLQASDGSIIIDNSQTMYFSKEEIMSVLEMETKRTAFRWHGNCFLRKDGIFQGSQLSSCLVDIVYDDLLESYKEFGTPPGHASLVMKLADDFLVISTSKEHVDRLKTLLHHGFQDYNASVNRDKVMSFYSPELSDPIFSFCSVNINILKLEVWKPKETYNKLQSYLSSANKLYKKLRWLFESRMAYEITQPTYNSWEAIVTHVEQATINLAETYSTCFSRHTKCVATFSEFIDGIVGAALKNCLHAENRTKRYIELRSIILSSFTETLKKKKSTFAEIVEFLQLQQGKPKDKLRCSEAEVAS
The following text describes a protein:
Function:
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
Sequence:
MGTIKNNFQLLWLILLIVVLVNGKSINKNNNNNKNEIINVTYDGRSLIINGERKLLFSGSIHYPRTSEEMWPIILKQSKDAGIDIIDTYIFWNIHQPNSPSEYYFDGNANITKFLDLCKEFDLYVNLRIGPYVCAEWTYGGFPIWLKEIPNIVYRDYNQQWMNEMSIWMEFVVKYLDNYFAPNGGPIILAQVENEYGWLEQEYGINGTEYAKWSIDFAKSLNIGIPWIMCQQNDIESAINTCNGYYCHDWISSHWEQFPNQPSFWTENWIGWFENWGQAKPKRPVQDILYSNARFIAYGGSLINYYMWFGGTNFGRTSGGPWIITSYDYDAPLDEFGQPNEPKFSLSSKFHQVLHAIESDLLNNQPPKSPTFLSQFIEVHQYGINLSFITNYGTSTTPKIIQWMNQTYTIQPWSVLIIYNNEILFDTSFIPPNTLFNNNTINNFKPINQNIIQSIFQISDFNLNSGGGGGDGDGNSVNSVSPIEQLLITKDTSDYCWYSTNVTTTSLSYNEKGNIFLTITEFYDYVHIFIDNEYQGSAFSPSLCQLQLNPINNSTTFQLQILSMTIGLENYASHMENYTRGILGSILIGSQNLTNNQWLMKSGLIGENIKIFNNDNTINWQTSPSSSSSSLIQKPLTWYKLNISLVGLPIDISSTVYALDMSSMNKGMIWVNGYSIGRYWLIEATQSICNQSAIENYSYIGEYDPSNYRIDCNKPSQSIYSVPIDWLFNNNYNNQYATIIIIEELNGNPNEIQLLSNKIIN
The following text describes a protein:
Function:
Required for nuclear membrane fusion during karyogamy.
Subcellular Localization:
Endoplasmic reticulum membrane. Nucleus membrane.
Sequence:
MKSAFPVAISSALTLLLSSFQLSTSQYHSPPANAAPTIDVGALFQHTTSRNQRVITQAVDFVISMQTAPTCTRMAASHLMNECKLLENAPDFAKARPEAYLDNIKTEYAAKLAVCELLSAQPHNPTPPPNCEMLVPTSKACGRGGTWWYSRPETSMNDKQCYPEIKEYQYAQCLKTLQSSPQYWTSFSNARQNAVVMCQASRDAIERENHLDIFKNLTQVMGAVSSAMKKSTEEYEALIKDQKQFADRVREAQDRFKEDVHAVQEKALATVGTLDTKFHNFMETSMSDLVTALADNQSNEIARIRQEMQAFSGDLMAESSQFARFYNDQLEAHHEHALGSLQANHEAQIDSYNVLSGRMSAIHNTAERTNFAANASLNTIISIEKQLVNLSGQADHIAQGFAFFSALPQLLSSLFRGIVATIGIAFLFSVLSKINKRLAKDAAGISSLLYFFHLCGLYQWLGNLPVLAATLHQHQGVSITANLSSTQKAAALIMLLWVGAYPVRCVNFYLGSMISAVVSKLLGSYWLQHYNNDGGFGLLPSIEVPASTASHKADRFDNGSLNMHPLAHARHSSSPTRA
The following text describes a protein:
Function:
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes (CRLs), which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The CRL associates with CDC34 as the E2 ubiquitin-conjugating enzyme. The functional specificity of the CRL depends on the type of the associated substrate receptor protein. RTT101(MMS1-MMS22) promotes fork progression through damaged DNA or natural pause sites by stabilizing replication proteins like the replication fork-pausing complex (FPC) and leading-strand polymerase at stalled replication forks. RTT101(MMS1-MMS22) ubiquitinates the acetylated histones H3K56ac-H4 at lysine residues H3K121, H3K122 and H3K125. Ubiquitination is required for efficient histone deposition during replication-coupled nucleosome assembly, probably by facilitating the transfer of H3-H4 from ASF1 to other chaperones involved in histone deposition. RTT101(MMS1-CRT10) may regulate nucleotide synthesis through transcriptional regulation of ribonucleotide reductase. RTT101(MMS1) is also involved in the non-functional rRNA decay (NRD) of 25S rRNA through the selective, ubiquitination-dependent degradation of nonfunctional ribosomal particles. Ubiquitinates the FACT (facilitates chromatin transcription) complex subunit SPT16 in an MMS1-independent manner. Involved in regulation of Ty1 transposition and protects the genome from Ty1 integration upstream of tRNA genes.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Recruited to chromatin in response to replication fork stalling.
Sequence:
MINESVSKREGFHESISRETSASNALGLYNKFNDERNPRYRTMIAELHEFFHLTLAETITETDVKELECNKEKAAKFRKLMPKMLNNCRELTQRKSYIPYNSEFNGNDEKQKKFQLLHQHQIVLSFQEFCDELAKLIIDAHVLSFLTRCDYSYEIIPKNWTSFYKLFQYVMGAVGPIISYVPVNYPMIRKELGFETLTIFQYYDSKLFECMKSHFGREFSTLVSATIHHYIHMFPITNTMLEKEVPMLRIMSNCNFSIEGLSPKDFYMKTLRQYYCEESNLRPRLETFKNFKVLLTRNALLASLFSPEWVSDANDLFISHLLLNKKSISEYIEIGKDTYDEEKERYFKTETHFSLLMFRNAFEAKNMLSKFKEFCDDAVSEKLKAAYGSNHDTERLFDEVVQLANVDHLKIYSDSIEYHLCNLLGSTSKAIEQYVKYFESHLFIIVRKIKTTKKDLPRDMKIKYLNENLPILRLKFVNLPTFPNFFERSIFRKTILQSDQNSSFIKDILPVYKDSLMELFKQRIITNVSQEDEMRYRDQYQPYLSQFFQPVEVMADLRIKYASFLSFYENIEAAVKFGKTYNENNSKSFFPLIFDRERIPKVFQQSNEVKKNFVLPQEMDDTWNQFLRNYHEQNKVEDSDASKKELYPMWNLHHCEVESPYIIQDGTNLIFELTLFQTCVLTLFNESDHLTLQVISEQTKLAYKDLALVLKSFCNYKILTRDIDNTYSINESFKPDMKKVKNGKLRVVLPRTASLQSSNTGGERTSSAHHEGSNSQWTQELLKACITRSVKSERNGLDYDHLFETVKQQIKGFSVGEFKDALAKLLRDKFITRDESTATYKY
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Nucleus.
Sequence:
MLGSGPPCCWHVWQQLLSLLATTSHGFWRVRVLSGVVLAKFFMTRIQDQPSTLPALTGLNELHKMNRTIFHGMAAELMTDIMKNVFVPAQAQPLRHQCFLLDAALLKTHLTELQTLGQQFVVGFVQQIDGEKDPRCLTQAFDLVPFVAKTFALTPNLTTALFEAISCYFPITFHPPPNDPYGITHEGLVAAHQACLSAHDAFAGPTIELVLDKLGSTIDETKMQCFETLAVVLPRFTVLKLLPYINKLYAAIRGEIYATAQEKSCYGLVCSEQSAHGDGNSLLSRGESSLLAVHGKLIVAAALASARACTLVFTDYVRPAADALMQTSQDSMRRAIGAILVDLLRAGSMCGLDESQRGLVLPIAQQLQDIMAGFALTRDDGLLQSYGVQGMMHFCELEGNAVDERQAVETTLHVLDQASPTEPLVALEAALECLGRMSQRNAAVVTDQLLQRLVAWATGDAVWAPIVAKRFPELFLHESAEPFVAQIFSTLFSAPTSSATLGLLQSCMVEASKHGALVQSLLPDLFQRLIEAACAAETLGASPQNPLCLGLAALVANANQRFLILASVPQQASQELQFSLLAKALDELLQGNAQSHPLCHAVICNLTREVSPALKQEAPLVQRVLAEVAKCSDDEAALRAAAPLATLLNKNPDALPYAELEAMVQSSPRPGVMSAIVYKALATQHHSSTTAARQQFVTLAVQGTLQMSLGTLLGFILEDDGWRFSRQGHCVVRLLYKQRVSQELLPALIEAHGTLTAEGRSNVLQGLASILEGASAQFISGQAGNILPLILKGVSEPDATLVEASLRALQRIMRSTPAAVDTHTHDVITRLLSLVQPQALAQVAELDAIKVARIQPALPGACSYVAPLIPALLDDQLMPDARVVIRQLQVCLNDRKRVVRNAAVKCRSIWIAKCG
The following text describes a protein:
Function:
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Subcellular Localization:
Cytoplasm.
Sequence:
MYANGDAARRGSCMDCFSSAWTCSRLTLLIRPLGTIKTLLAYIRDHLLKERPELFMDGETMCVNTFLTNDVGHPHTRLTAFAFTDLHPARPYLVFRLLVMLVGITNSMADVNACSRPGILILVNDTDWELLDGLDYQLQDKDNVVFISTLHGG
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MDRGRPAGSPLSASAEPAPLAAAIRDSRPGRTGPGPAGPGGGSRSGSGRPAAANAARERSRVQTLRHAFLELQRTLPSVPPDTKLSKLDVLLLATTYIAHLTRSLQDDAEAPADAGLGALRGDGYLHPVKKWPMRSRLYIGATGQFLKHSVSGEKTNHDNTPTDSQP