lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR (By similarity). In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs. Prevents plasticity in the primary visual cortex late in life (By similarity).
Miscellaneous:
MISCELLANEOUS: Isoform 1 is considered to be an endogenous 'prototoxin', that shares a N-terminal three-finger structure with snake alpha-neurotoxins; MISCELLANEOUS: [Isoform 2]: Based on a naturally occurring readthrough transcript which produces a LYNX1-SLURP2 fusion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Cell projection, dendrite. Endoplasmic reticulum. Note=Detected in Purkinje cells soma and proximal dendrites.
Sequence:
MTPLLTLILVVLMGLPLAQALDCHVCAYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCFETVYDGYSKHASTTSCCQYDLCNGTGLATPATLALAPILLATLWGLL
The following text describes a protein:
Function:
Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MADVVCMPLIGRLGSPDLVTTFYVGMGLGALLPSALSFAQGINGSTWNFSYSVFIYIICVLDAVSLVAYFGILYLEKRKVNNNDEERTRTLSQTTTETKVEQVPVEVDSSLRSMLFPMLVTLIASSFQNAVLPAILPYATQPFEPTIYSLSTNLFVLTNPIFCFVQHFYSFSSTIHLSILSIITAIPTLFILVLSIAQLSIPAALLPIASGLSAGFLSLLRTAAASRIAHSSHPKALFICGFMTQFGSFVGAIIIFILANAFHIFISS
The following text describes a protein:
Function:
Small GTPase which regulates vesicle trafficking between organelles (Probable). May be involved in the trafficking of the N-myristoylated AK2 from the endoplasmic reticulum to the parasitophorous vacuole membrane.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Vacuole membrane; Lipid-anchor; Cytoplasmic side. Vesicle. Note=May localize to the endoplasmic reticulum and to the parasitophorous vacuole membrane.
Sequence:
MGCSSSTERLTSTKNINIVTSPAQQQKKNAQDTKVKIVLLGDSGVGKSSIALYLCHGRFSEKHQVTIGAAFLHHNIELKNGATMKLHIWDTGGQERFRSMAPLYYRDAYGAVVVYDSNNVESFDSLKYWINEIKSNGPRNCCIMVVANKKDLPQKLNSEMVMKFCEQENVSFIECSAKTGENITTLFEKLASRIYSRFKEVLYYNNP
The following text describes a protein:
Function:
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
Sequence:
MDFKVVERFVSINGEGRRCGQLAIFIRFAGCNLNCSYCDTLWANEKDVPYEVLSSKDIYEYIKSKEVKNVTLTGGEPLLQKGIMELLKLLSKDKELYVEIETNGSILLDEFLNIENSPSFTMDYKLPLSNMENKMALDNFKYLTKKDTVKFVSGSIEDLEKAREIINKYNLVDKTNVYISPVFGKINLDTIVEFMKNNRMNGVNLQLQLHKIIWEPSKRGV
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTNALSMDKALAAACSHPSLGLRWDDLCVACTCLLGYTPTKFELASMFGDAVMQADRLPISQSQFKQVMATRMSKIDPDETIRQIFLLLDTESKGYINQEDLGNGLKKCIPHHSQSLEVGSILSKHITSNQSGFNVKITYRQFRQIIATFTQSKEYLLAQRNGCKSHTTAEPFFHDPKKVHSLGSQLLQHASALPTIEKFAIIDQVFHACIDTGHIEEAKDHLTTIEAAFPFGKSLRTRRLYGLYHEAMSDSTKAMEIYNLALDTDEASMPLWRQSVARLISSNQRPQAIEALSLYVDRFMQDVEGWTMLAKLYADEGRFEQAAFCLEEVLTLRPQHPLYRVRYAGIVSSLGRLSLAVKVYSAALVTLPDHVGALYGLRTVTKNILDLETVSNKKSSMVQTGSYESDPIIPLDRVKMLHVLAKERLLELYEAQGKSGQDMTSILKAWLHSQDH
The following text describes a protein:
Function:
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.
Sequence:
MSKLTQSSYHGVDSTPLLQEKTIGQLLQETAQKNPDKEALVFCAEGVRKTFSQLLQETDALAAGLLALGFQPGDRLAVWSPNRYEWVLTQYASAMVGIILVAVNPMFGPEELKYALNKVQPQGIVIAPASPKRDFYKVLMSVVSSDAGSSSLSQLKVISMKEGETEGDVLKFWEVTKKGGEQEVERLKQLQQTLQPDQPIHIAFTSGTTGPPKAPVFSHRHVINNCYFTGRRLNYHEEDHRLCVPMPIWRALGMIVCNLNPLVFGHTAVYSGPDFNPKAVLAAIHKERCTSVYGNSPMLMALVKQPTFGDYDVSSLKTAMIGGQGIGGSDLPLQMLQMFKQKLNLINVTVAMPMTECGPVAFQSVLGDPEEKLTSTVGRTLSHVEVKVADDAGCTVPVNTPGHFLTCGYYTMLQYWGDQEKTDQAFTADGWFHTGDIISMDEDGYVQLLGRESERIKLGDSYIFPKELENVLRSHKQVKDGQIVELSVSGETKLCACVVLESGASLSETDMLDFCKDKLPAIQVPQFVCFFDTFPLTPTKKVKKSEVKLEAERRLKLSSSG
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.
Subcellular Localization:
Nucleus.
Sequence:
MAGELADKKDRDASPSKDERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSTERDRRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRKDRDFKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREEKDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA
The following text describes a protein:
Function:
Plays a role in the formation of functional neural circuits from the early stages of synapse formation. Has a role in the development of CNS functions involved in locomotor activity.
Subcellular Localization:
Secreted.
Sequence:
MWSRQRMRHKPLWALISLTVLLLVLDKSNANTEPVETSTTSEPDASPGCRAPDVRFTIVKPEATTEQPLAKFETTQIYLPEDFTTADVEFVDSVPRHPNENHAAVINPYSLDLGDDHLHVGDAAASLVGDDDLGDEDEDHHGDPEDKRLNANRKQGKRRRAGSGRRRRIENENGQTGRGRGSRYKRHAILHDTEASPETDRWAGSKLAAEGDVYYVHIADILKSREPNRELKSKLHKLKMKARLNKCLAEGGKEKCTRLLKKKPKKKVVEKEQTLKKEKKFPKEEQSKEKVPENGQTPKEDELELDHPETAAAHHRRRGDSHAAELDQRDRSPRWRRRRSTEFKGDLGQLPPESGIGPEPEPLADQDLKDLQQYGNQSSSARVALLWQRVKRKSGKTTGALSRPKGGGDSSSKTTSRKDKGIYDEEAGYTPIHPDDPEFDEEEEEDEEVDILQQFTEVSEIRFPGEIGPMGDRRLCKIRCVKGKWVGPLCATNEEDDNGNVKFQPLYKSCHVNRIPSHLLLSYRNISVTPIPPNRGWRKTRLSKSTLLSNTEINVGWDLPHGHSLQARCQELGIYKLLGESRVLCSNGLWAPRMPSCVPTTVLTNYSEDSAPSIRIKIFNGSHSFEPSGVMAVPPHSTVLMDCMYPRVRGTPEWSWTSWYMQYSTGWSPAQEEKAVRYRLSIKNIENNDSGTFTCTSPRGLTNSIAVVVATSTCPQLTEPLAPLKLRLEGNKLGQRAHYECPEGFRLDGAWNATCLASGNWSSPTPTCHAIQCPRLELDDPHLSLIELNTSAWGRAVFKCQWGFKLTGPAQLDCEPSGVWSGPVPRCKVIQCVMPVAPLNGRIGGTSLSQRRLTVGALVTFSCNDGHSLVGESSIICTENGQWSHSPPFCKSQCPYPGDPPNGLIAPLKFNYDAGDYLSVQCRPGFVQSYEGPPERPKCQPDGRWSGPMPKCKSYEEV
The following text describes a protein:
Function:
Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
Miscellaneous:
MISCELLANEOUS: [Isoform D]: Produced by alternative promoter usage; MISCELLANEOUS: [Isoform A]: Produced by alternative splicing of isoform D; MISCELLANEOUS: [Isoform B]: Produced by alternative splicing of isoform D; MISCELLANEOUS: [Isoform C]: Produced by alternative promoter usage; MISCELLANEOUS: [Isoform E]: Produced by alternative splicing of isoform D; MISCELLANEOUS: [Isoform F]: Produced by alternative splicing of isoform D; MISCELLANEOUS: [Isoform G]: Produced by alternative splicing of isoform D; MISCELLANEOUS: [Isoform H]: Produced by alternative splicing of isoform C.
Subcellular Localization:
[Isoform A]: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus; [Isoform C]: Nucleus. Note=Predominantly nuclear.
Sequence:
MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPRDLGWEPAVERDTNVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG
The following text describes a protein:
Function:
Involved in the biogenesis of peroxisomes.
Subcellular Localization:
Peroxisome membrane; Peripheral membrane protein; Matrix side.
Sequence:
MKPLAYYEDQLLKDEKSFLKVTEIERLLSYAAYLLPAEFRDDQLKSQTITSILLLLHQFHTGLLFRKIAELPKTEQAILKSERTQYLEYFRKKNPSFEKVSELLYFLNISTFPIELVISKYNPSRQYDSVLFLESVKFLLRVHIMWTTGGDLPLSNPVLQRDFNVKTFIHLHKKYSNSGSAVVLKNSKKVVPRLNTVNSSLDFLQNRTPRLSSILPDEIFTKRLPNLRIFSNFIKVCRPLIYMLFMWHWKRKQKSSSLKVRPWGPWIVAFVFEVISQLIDRRCESATSSRQGFGLERRTNQSQFQHFVVWAFTQGRFYDEFTKHWINRSLSWVNSIPVFGKYLLLSVEERQKSLENYISSVRNY
The following text describes a protein:
Function:
Host inclusion membrane protein probably involved in early modification events of the chlamydial inclusion.
Subcellular Localization:
Secreted. Host vacuole, host pathogen-containing vacuole, host pathogen-containing vacuole membrane; Multi-pass membrane protein. Note=Secreted, probably by a type III secretion system (Probable). Localized in the inclusion membrane. Inclusion membrane staining is punctate.
Sequence:
MTKVYAHSIQQERVVDRIALLERCLDLSNSLPTAKRLAAVAVATILAIALLVVAGLLFSGVLCSPVSVVAASLFFGVGAFLLGGALVGGVLTTEAVTRERLHRSQTLMWNNLCCKTAEVEQKISTASANAKSNDKLENSVSKKGAS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAAARPEAQSPSSPTPESRSQEPLDLVLVPDDCRPGTPPSDLIEIQVVKVTDTTLVPEPPEPGSFHCALCPAAFRLVSELLFHEHGHLAGAEGGGQGGDPSRCHVCGHSCPGPASLRAHYSLHTGERPYRCALCPRAFKALAPLLRHQHRHGVEPGTSQRPPDAAAVAEQRPGVAPERAEVVMAAAAAGAAVGKPFACRFCAKPFRRSSDMRDHERVHTGERPYHCGICGKGFTQSSVLSGHARIHTGERPFRCTLCDRTFNNSSNFRKHQRTHFHGPGPGLGDSGGQLGSSAAEGSGSRQKTLTRLSVKRLWDPITSKPEGPQVTAEST
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MFWTSVARARSVWKGPNVVDFGVNVQQCIKGNVPIKTAVRSATILPRMVGAQFMVHNGKSYANVKITEDMIGHKLGEFAPTRKAFHYRQTKNR
The following text describes a protein:
Function:
Possesses an intrinsic kinase activity. Displays 3'-5' exonuclease activity with a preference for single-stranded DNA. Does not seem to have nucleoside diphosphate kinase activity. Functional component of the gamma-tubulin ring complex, implicated in the regulation of the microtubule-nucleating activity of the gamma-tubulin ring complex in centrosomes, in a kinase activity-dependent manner. Part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MNHSERFVFIAEWYDPNASLLRRYELLFYPGDGSVEMHDVKNHRTFLKRTKYDNLHLEDLFIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAISKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHNMVTEMYSGPCVAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLELINYLRSSDV
The following text describes a protein:
Function:
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
MSSMPLLDDARLSRGVGIRFVSLVVPVTVTMLAVVWSLSCLSPIYVNSQAPPLPVVVNENDAGTAGEKFVYSLVAALIVVGCVVVATFATVVLYHFHLQFVLYGWLAFSAVSMFFMLLWIWLDLFCTYFQIPYNVISMGIFVWNFGVVGLIALFYYSHPTVTQVYLVIASILTAWSLTALPEWSTWALLMCIATYDILAVLWQQGPLHRLIKIAQERDEPIPGFVYSSAHSIVPITQPATASSARVPATAAESFTSTVQHATPFKLGLGDFIFYSLLVGRASFSGFVSWGFCMVSILAGMLGTLLSLLLFRNSLRALPALPCSIFLSTVVFVLCRLIVESLSSFTSHHLLVL
The following text describes a protein:
Function:
Part of an ABC transporter complex involved in ferric-petrobactin uptake. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MITLEYRKKENVEIDSSLHNESRSASAFRSKKEARRYWILLITLIALGLLSSYGLLVYNNPVPIDSPSFIPVVKRRIVAIVAMIIAAVCHSLSTVAFQSITNNKIITPSLLGFESLYSAIQTSTVFFFGASALINFNGIGSFLFQVVVMVFMSLILYGWLLSGKYGNLQLMLLVGIIIGTGLNSVSTFMRKLLAPSEFDILQARLFGSVNHADPAYFPIVIPMIIIVAVLIFAHSKNLNVLSLGKDVATSFGVKYQPSVIYTLVLVAILMSISTALIGPLTFYGFLVATLSYQAASTYDHRYIFPMAFAIGFLIMTSAYFLMYHVFHAQGVVSVIIELFGGIIFLTIVLRKRAL
The following text describes a protein:
Function:
Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MEEENDVKIKTKFLGQMVVIYQRLPLRLATLYAALREACKQPSNQPITIKWIDEEDDPCTISSQTELDEAVRLYQVNGDAELNMHVFIGTPTLPGLPCNGEDKTVYRRGARRWKKFYHVRGHRFSAKRLNRRVMCEICGDYIWGIGRQGYRCLDCKMCVHKKCHRLVRKTCGEAGIPGQAVPVAPQPTRPFGSLNGNRPEGIDNAAFKESEIEAPEGADVRPSGGTAAPAKWTVSLNDFNLLTVIGRGSYAKVIQAEHKRTKAIYAIKIIKKQMFNEDEDIDWVHTEKSVFEAASNYPFLVGLHSCFQTDSRLFFVIEFVPGGDLMFHMQRQRKLPEDHARFYSAEIILALHFLHSRGIIYRDLKLDNVLIDAEGHVKLTDYGMCKENVGPGDVTGTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFELGDMQGDGDLNTEDRLFQIILEIRIRIPRSLSVKASTILRNFLEKDPTQRLGCKVDIDESLSDIKDHSFFRTHIDWDRLEAKQIAPPYNPSVESDRDLQHFDTQFTDESPTLTPDDPDVIARIDQSEFDGFEYVNPLQMSREDSV
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MAGWTDSTGSGGRGSGGRGFTTPRYTTNSTNDMIHGGTSGGGGGSGRWRGGRSRGWPPPQPHHRYRRVDAVHRDSAPVSLSELQAASSTSSRHRYLTRSISADKSSASGTAGSTDTREPDDKANRSAANFECNVCFDMAAEPVVTRCGHLFCWECLYQWLHVHSHHRECPVCKGQVADDAIIPIYGRGGSAASVDNAPPRPTGARVESTRQQQQQLPIFHPPNVFEFIGLGLAAAARGEHSTEQLLLPTFSHPTVFDDDDGHEWDMDLVNNGIDPLDLITPGTQDLDMDDYDGTIDFDDDDYEYDYHLAGATLFASAGTEASNPSSSQAHAGMINIRDNILGTATSIYHQQEFGYSGVRPHNNRGRRRHRNRARASANHSGADEMVIEDTSHFYLQNGGSSNISAGAAFRPNGGWTGRRGRSNLNSNSGGGSNLNSNSGGGSNMNSNSGGGRGGIQGTRRQRTNYN
The following text describes a protein:
Function:
Involved in the biosynthesis of kanosamine (3-amino-3-deoxy-D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the oxidation of glucose 6-phosphate to 3-oxo-D-glucose 6-phosphate. It can only use NAD.
Miscellaneous:
MISCELLANEOUS: The production of neotrehalosadiamine is dormant in the wild-type strain. A mutation in the beta subunit of RNA polymerase activates the production of the neotrehalosadiamine.
Sequence:
MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVKTFGGKSFENVDELIDASEGLIVASPNFCHKEHALQALGKHKHVLCEKPMAISLEEASIMKDTAERLSVRASMGFNYRYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFTWRDDANSKKTSGSLGDLGIHLIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDDYAEIYGQLKNKVFVNIITSKCSVPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNVVDCPVPQSLLNDPPNEFYGWADSFRSELINWIASTQNDWVEIPSFSDGFRSQEVLEMFFEKDSNSQPMSVSAVN
The following text describes a protein:
Function:
Acyl-CoA dehydrogenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide synthesis is a prerequisite and a key checkpoint for chain transfer between PKS and NRPS modules. The downstream NRPS module contains the condensation (C), adenylation (A), and thiolation (T) domains and catalyzes the incorporation of tyrosine via the formation of the L-tyrosinyl-thioester and the amide linkage between L-tyrosinyl-thioester and the tetraketide. The bimodular assembly line is terminated with a reductase (R) domain that facilitates formation and release of the tetramic acid product. Because apdA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase apdC. ApdC appears to operate with different stereoselectivity in different PKS cycle (Ref.5). Combined with apdC, apdA is proposed to synthesize preaspyridone A via about 20 enzymatic steps. A number of oxidative steps performed successively by the cytochrome P450 monooxygenases apdE and apdB are required for the conversion of preaspyridone A to aspyridone A. The cytochrome P450 monooxygenase apdE is responsible for the oxidative dephenylation of preaspyridone A (Ref.5). Finally, the predicted FAD-dependent monooxygenase apdD and the acyl-CoA dehydrogenase apdG may be involved in the transformation of aspyridone A into aspyridone B (Probable).
Sequence:
MAEISSVPFAEPPYLRGLPSPYYNESHRRFQKACRAFLYENLLKHAMEWEKAGTVPEHVFSDFCKANMLLPNLPAPLPVAWLKRLGIHDILGVKVEEWDYLHTGIYSDEMARSGLSGPSGSLTAGFAFGTPPIIKYGSKELQEKFLPDLLTGKKRNCIAITEPDAGSDVAGITTTATKSADGKYYIVNGNKKWITNGIWSDYSTMAVRTGGPGAGGLSLLVVPLKNYPGVTMQRLKVSGQITGGTTYIELDEVKVPVENLIGLEGDGMKMIMNNFNHERLTIAVGVTRQARVALSTAFSYCLKREAFGKTLMDQPVVRHRLAKAGAELETMWAFVEQLLYQLTNLPKEEADRQLGGITAMAKAKGAMVLNECAQTAVLLFGGAGFTKQGQGELAEAILRDVPGARIPGGSEDVLLDLSIRQLVKLFKAEEKKLGKARI
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTTSMDFYSNKTFQQSDPFGGELMEALLPFIKSPSNDSSAFAFSLPAPISYGSDLHSFSHHLSPKPVSMKQTGTSAAKPTKLYRGVRQRHWGKWVAEIRLPRNRTRLWLGTFDTAEEAALAYDKAAYKLRGDFARLNFPDLRHNDEYQPLQSSVDAKLEAICQNLAETTQKQVRSTKKSSSRKRSSTVAVKLPEEDYSSAGSSPLLTESYGSGGSSSPLSELTFGDTEEEIQPPWNENALEKYPSYEIDWDSILQCSSLVN
The following text describes a protein:
Function:
[Isoform 1]: Participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes. Protective against the mitochondrial apoptotic cascade (By similarity); [Isoform 3]: Participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes.
Subcellular Localization:
[Isoform 1]: Peroxisome membrane; Multi-pass membrane protein; [Isoform 3]: Cytoplasm.
Sequence:
MASWWRAFPQAARRYPWPTNVLLYAGLFSAGDALQQRLRGGPADWRQTRRVATLAVTFHGNFNYVWLRLLERALPGRAPRTVLAKVLCDQTVGGPIALSAFYVGMSVLQGKDDIFLDLKQKFWNTYKSGLMYWPFVQLTNFSLVPVHWRTAYTGLCAFLWATFLCFSQQSGDGTLQSIFIFLRRKEASDKSPEK
The following text describes a protein:
Function:
Probable permease involved in the uptake of 3-phenylpropionic acid.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MQVRPFYWLALSFLGYYCAYGVFLPFFPAWLKSQQYGEEMIGLVIGSAYIFRFAGGLFFSSLIKKANHIIIALRLLALASAIIMAAMSLVAHNFWLLFIAIGLYASVNSAGMPIGDSLASTWQRQIGLDYGKVRLIGSAAFILGVVVFGGMIGWVGEQNIVWILTALLSFYTIIQLLKPTIPPKDEIPEDSVQNDVGFIALLKNPMTLRVMIAVGLIQGSHAAYYVYSTIYWTSIGISVSQTSLLWGIGVLAEIVLFFFSRRLFQNISISVLLYISALACVGRWAVIGYIEDFWLIFLLQLMHSLTYAVCHYAIVRYITTQPQSHIAKLQGLYNGLSNGVLIAIFTAIAGMIYPTSPAMTFVFMSIIAAAAFFVIPRKLNAFLIVQHK
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MKGYLILYNSVSAILWGYILFQCFRDWNIGYYEVEEIPHKFMVYTQIFNSSIEIFHSMIGLVPTPIPTLLLQSFARLIIMVGICVVIPESLANYDITVFSGLTLAWSITEVIRYGFYVIKMFGIATPYWLVWLRYSAFLVLYPLGLVCESTTVFNSYDYVKTKIPAYYYFLKYAIVLYIPGFLYLYTYMIGQRTKVLKKIKAE