lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in septum formation. Required for the proper localization of chs2 at the septum.
Subcellular Localization:
Cytoplasm. Note=Localizes to the cell tips and septum during vegetative growth.
Sequence:
MDSASSMRNRSPLGVPEFSYSSQSVNNIRGIKSRNRSSIGHSITDPQVASRINAFYLSNVQSSIPFETDAIGPAYGIGDMIAPEMNDTQSLSASVTNMKKENFYSRPNVSSSSILLTIKRATSSQETKRDRPLPNIRNSAPSATRSHSTPCVAPGYLRTSNEAADVVFPHEEAHFSNHNPKPNNGSPLQKQVVADLPFPLPVSDEEQLDWIRANEDLVHSQDIDEALEWAEYVLRFTQSHLPYLQTYESENLHEINYLESMCENALYKIREFSELENAKAMYFDAYVYETGAFDVESDIQRAWDLYSSSANLGYTRSLYRLGVLLEDQGNLEEAVEYFEKGVSENDSACCWRLSLLILEGMLDGVGEYAHRHASGLELLERSADTADADVPSGLYSHALVNLHEHPGLVDLGSENIRVPIDEATALKSFAKAAFLGHSSAQLRMGAVYEFGKYGCPVVPRYSLFYYSAAAKRGETEADLAVAKWYLNGSDGIPVDEDLAFMHAERASMAGNANAQFLMGYLFDTRGNTEQATYWYNEAAKAGHSEAIERLALLENQIQEPEPENITSSQYPNQDVIKEIPVTASETSPPHAPAVSSTPVTSAPPVSQTKVTKVSVPKKTSKKFLIKHNKCIIS
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
METTRSDGSIMVVGAVDIDCPQHRLCGYRDLIRGVSGGGAAMSRWPEAAPFVPQIASTGGDGGAAVAGGGWSSGSSSPAPSSCSSSSSWREGDCCYDVCWCSSSTVHELRSIAERMVRDGYIEGLIRAFGGAATAGAAGRRGPPDELLLHNWFSQLDVEWVLLLHTCSEEEEDEHVRRPPPLPVEDLMALMERWIRALLTMVQVLCITQLELRAKKPTVAGVRRAIQFFLLRRDSKTAHADYVQQVVQFARFAEESILRMLAFVDAATLAVVEEDDDDHRVAEALPGMLQVYACISEASPTVLAMFKEASDLLASGSSRHGQEAQVFDGMDGIFLRKRKKLSDAIWDMMEKVRSSFLQDGCWQVSPEASASGVHETTVLMMNYIALLWRNDDVLTFILQDHHFSVFVSHTQGFSSVVNLITDIISCLGHKLEEIASSLSNSILDPALRCIFLLNNWQLVLHRIESLDLPSWALIDRCRTRRYIDTYIDVFWSPLLCCIFIGNSSDTPRKKTYRPAFGFRRYLSLENFEIEFRKTYAKHKFFKVPDPKLRQRLRQAIIQKIIPHYSMYLEERAARGMHNRPPKITPEQLKELLEELFEG
The following text describes a protein:
Function:
Involved in the regulation of lateral leaf growth. May be involved in the regulation of basipetal polar auxin transport (PAT) and vascular patterning in leaves. Controls photosynthesis rate by regulating carboxylation efficiency and consequently photosynthesis rate. Controls panicle and spikelet numbers, and grain yield.
Subcellular Localization:
Nucleus, nucleoplasm. Cytoplasm. Note=Expressed in discrete structures which appeared similar to nuclear protein bodies.
Sequence:
MKPSDDKAQLSGLAQSEESSLDVDHQSFPCSPSIQPVASGCTHTENSAAYFLWPTSNLQHCAAEGRANYFGNLQKGLLPRHPGRLPKGQQANSLLDLMTIRAFHSKILRRFSLGTAVGFRIRKGDLTDIPAILVFVARKVHKKWLNPAQCLPAILEGPGGVWCDVDVVEFSYYGAPAQTPKEQMFSELVDKLCGSDECIGSGSQVASHETFGTLGAIVKRRTGNKQVGFLTNHHVAVDLDYPNQKMFHPLPPNLGPGVYLGAVERATSFITDDVWYGIYAGTNPETFVRADGAFIPFADDFDISTVTTVVRGVGDIGDVKVIDLQCPLNSLIGRQVCKVGRSSGHTTGTVMAYALEYNDEKGICFFTDILVVGENRQTFDLEGDSGSLIILTSQDGEKPRPIGIIWGGTANRGRLKLTSDHGPENWTSGVDLGRLLDRLELDIIITNESLQDAVQQQRFALVAAVTSAVGESSGVPVAIPEEKIEEIFEPLGIQIQQLPRHDVAASGTEGEEASNTVVNVEEHQFISNFVGMSPVRDDQDAPRSITNLNNPSEEELAMSLHLGDREPKRLRSDSGSSLDLEK
The following text describes a protein:
Function:
Required for sporulation where it is believed to have a role in meiotic nuclear division.
Miscellaneous:
MISCELLANEOUS: Present with 952 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MVDSNDDQPERHALLHNDIQTSNNSRPSLVQKKYLPTPQDTRKSRASYTGSAMINPTSKQSRTGSGAQRTSRTAQKLKLLPEEPFQRDSERLTDLKNQEVYSQVNRIKDKPARRDAEKLGKAHRHLLPRSTAYCTASSYNMKELVRWLKDCRKLHHTHPKLFDECLYTPFIYNDWRGDKRFEDEDVIRLDDEGGEIIVSDKHPDLFIFEYGVVVMWGFTEREEKAFLNDIEKFEKEKLAEEDIQVEEFNYYVTKSYQPRIYNDFITLRDGSNYMVKLSISHAIAQSVKISLFEELVDNTIEDTQDIPQEIAYSGKVSMSKEDIMKSIGELFILRININLHGSVLDSPEIMWSEPQLEPIYQATRGYLEINQRVSLLNQRLEVISDLLQMLKEQLGHSHEEYLEFIVILLVGVEVLISVINIVVDMLASQH
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs) (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDIHRCRFIDYTPSAITAMAFSHKSGQNDSMPNNLLLAVGRASGNIEIWNPRNDWCLKTVLYGGVDRSIEGIVWSTGEEELRLFSIGFSTTITEWNLHTGKPLVNQDSNAGAIWSIAICDETKTLAVGCDDGSCVLFDISGGPGVIEFKRVLMRQTSRILSLDFQTKDHLVGGCADGVIKVWDLSTPNSAIISRMQVDRARKGEAALIWAVKSLRDGTIVSADSSGAVKFWNGKFFTLSQSFKLHLADALCLGVSANGDMVFSSGIDRKTIQYSREGGKREWVSNSFRRFHSHDVRCMAVFECKSLDVLISGGMDMMLAVIPVRQFNRKNHRMISAVPQRPRMAVAPKARLFMLWNDHEVLLWRIGSPGYRFLLKIVLADEENISHAAISPDGELIAISSVLRTKLYQLQYSDENVKVETVEDSFLSNIGASLLSFTVDKNKLILVSNDSEIFLIELSRLDSRQLEVFELSQPTSKKIAPRQRSNVSSMCDGICSIAVSSDGDYFAVADTVGNIFCYSLSNLTYSELPRVNTYVRAMAFRPDVRGRLAVATAGNQVYEFDVQSRKLSEWSKNNSTNMPKEFSQLLDKAFGAFFDSKHPSRFWIWSANWVSFFDLNLQLPAPRAAGKRKIEMNATVDGNLNDKKLANANSNGISNYGTGDSRCFWITHKYRPMLLVGSVGNSELLVVERPIADMLMSKSMPASFYEHKFGS
The following text describes a protein:
Function:
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
Subcellular Localization:
Periplasm.
Sequence:
MHRQLRYAVLATALFASTAFAGARQELDTFTRGLKGLDGQFSQRVTDANGRVKENSSGRVALATPRQFRWEYAKPYKQLIVADGKKVWVFDPDLEQVTVRAQGSEEQNSPLVALIDPTRLDKQYDVSEEAAPRDGLQWLSLTPKVDTDASFQMASLGFGKDGLAKMEVVDAVGQRTAISFSGWKRNPAFAADTFRYTPGKGVDVVGDAQ
The following text describes a protein:
Function:
Probably involved in a TGF-beta pathway. May be a receptor for TGF-beta-like ligand daf-7. Controls the decision of whether or not larvae enter a developmentally arrested state, known as dauer, in response to environmental conditions. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. In AWC neurons, acts to promote expression of srsx-3, a member of the GPCR family.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MRIRHVVFCLLALVYGAETSDDDLDERTNIFIRDKLIPALKLAEVTKVNFTRLHLCHCSREVGCNARTTGWVPGIEFLNETDRSFYENTCYTDGSCYQSARPSPEISHFGCMDEKSVTDETEFHDTAAKVCTNNTKDPHATVWICCDKGNFCANETIIHLAPGPQQSSTWLILTILALLTFIVLLGIAIFLTRKSWEAKFDWYIRFKPKPGDPLRETENNVPMVTMGDGAGSSVPEVAPIEQQGSTMSTSAGNSFPPGIMPNNMKDMLDVLEETSGSGMGPTTLHKLTIGGQIRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFHKETEIFETRMLRHPNVLRYIGSDRVDTGFVTELWLVTEYHPSGSLHDFLLENTVNIETYYNLMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDIIANENYKCGTVRYLAPEILNSTMQFTVFESYQCADVYSFSLVMWETLCRCEDGDVLPREAATVIPYIEWTDRDPQDAQMFDVVCTRRLRPTENPLWKDHPEMKHIMEIIKTCWNGNPSARFTSYICRKRMDERQQLLLDKKAKAVAQTAGVTVQDRKILGPQKPKDESPANGAPRIVQKEIDREDEQENWRETAKTPNGHISSNDDSSRPLLG
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MEPERLKFGGPRELCGAADLISQFKLVQHHEFFCKKSLPVSLSDSHYLHNVVGDTEIRKGEGMQLDQLIESISQSRETNIRIQPFDIDELQESFQLNDMTPVELPPAEKGAPTIPSKSKSESKDRDRKHKKHKDRDKDKDREHKKHKHKHKDRSKDKDKDKDRDRKKDKNGHHDSGDHSKKHHDKKRKHDGDEDLNDVQRHKKNKHKSSKLDEVGAIRVAG
The following text describes a protein:
Function:
Involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Acts as an arginine methyltransferase and probably acts by mediating arginine methylation of ndufs2 (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MFRSITQRVIRNNCYKQSTKSITSSTSFINNSLSYTTTSNENDIKDKNEEHDHRAKGKGRELLLSFDKSGLAQFPKQVFKNRKYPITDFEKYLQDITKVRGPMSIDTFIKEVLTNPKYGYYMNKDVFGKGGDFITAPEVSQLFGEMIGIWCVATWEAMGKPKKLQIVEMGPGRGTLMKDILRSTKVFKEFYDSISVHLVEASPANKKTQKQNLLYFKDKAINFDHKTIGETPNGIKVTWVGKLEEVPTDIPTLFLAQEFFDALPIHVFRFSREKNDWCEVLVDEDITEHGEYYLRFVQSKGPTLMTTAVKHLLPEFGLDGYQVELGLAGLAISQQIANRIDKSGGAALIIDYGYDKIVKSSLQAIRDHEFVDILDKPGTADLSVWVDFQTIRKTVKLLKNKSTAIGPVDQGIFLKEMGIEHRLAQIGRKLDSNEKFEELVMGYKKLVDPKEMGTNYKVITICDKNITPIGFSTSKTYDDEDLMI
The following text describes a protein:
Function:
Important for breakdown of endosperm starch during germination.
Miscellaneous:
MISCELLANEOUS: Binds starch not only at the active site, but also via accessory binding sites on the protein surface that are important for efficient binding to starch granules and thereby increase enzyme activity.
Sequence:
MKNTSSLCLLLLVVLCSLTCNSGQAQVLFQGFNWESWKQQGGWYNMLKGQVDDIAKAGVTHVWLPPPSHSVAPQGYMPGRLYDLDASKYGTAAELKSLIAAFHGKGVQCVADVVINHRCAEKKDARGVYCVFEGGTPDDRLDWGPGMICSDDTQYSDGTGHRDTGEGFGAAPDIDHLNPRVQRELTDWLNWLKSDVGFDGWRLDFAKGYSTDIAKMYVESCKPGFVVAEIWNSLSYNGDGKPAANQDQGRQELVNWVNAVGGPAMTFDFTTKGLLQAGVQGELWRLRDGNGKAAGMIGWLPEKAVTFVDNHDTGSTQKLWPFPSDKVMQGYAYILTHPGVPCIFYDHMFDWNLKQEITALAAIRERNGINAGSKLRIVVADADAYVAVVDEKVMVKIGTRYDVGNAVPSDFHQTVHGKDYSVWEKGSLRVPAGRHL
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEKKKEEDHHHQQQQQQQKEIKNTETKIEQEQEQEQKQEISQASSSSNMANLVTSSDHHPLELAGNLSSIFDTSSLPFPYSYFEDHSSNNPNSFLDLLRQDHQFASSSNSSSFSFDAFPLPNNNNNTSFFTDLPLPQAESSEVVNTTPTSPNSTSVSSSSNEAANDNNSGKEVTVKDQEEGDQQQEQKGTKPQLKAKKKNQKKAREARFAFLTKSDIDNLDDGYRWRKYGQKAVKNSPYPRSYYRCTTVGCGVKKRVERSSDDPSIVMTTYEGQHTHPFPMTPRGHIGMLTSPILDHGATTASSSSFSIPQPRYLLTQHHQPYNMYNNNSLSMINRRSSDGTFVNPGPSSSFPGFGYDMSQASTSTSSSIRDHGLLQDILPSQIRSDTINTQTNEENKK
The following text describes a protein:
Function:
Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MFKCLAAVGTVVWMTMFLFLYQQLSVNQNSGDSIRAWRETKEAIEKLQEQNMNLKNILKMERQERNDQHRKILEQAHQNPGNAELPRAEPEKEEKEVIQKPSILGSLEQELHKRMLDDRIREMFYLVHSKAIENSTKTLIENQMISLMGLSAKLEKLEGSEDERIKERSKITERIMKSIEKLQNPESCKNANTLVCNLDKECGFGCQLHHVTYCAITAFATKRMMILKRDGSSWKYSSRGWTSVFEPISKCTFDEAVGNTESKPFADPSPARVVSLGIVDSLLTKPAFLPQAVPEQFLETLHSLHSHPPAFFVGTFISYLMRFNAETKEKLEAALKAIPFDQGPVVGLQIRRTDKVGTEAAFHALKEYMEWTEIWFKVEEKRLGKALERKVFIASDDPTVVPEAQKDYPNYKVYGSTEIAKTAQLNNRYTDASLMGVITDIYILSKVDYLVCTFSSQVCRMGYELRQPSGSDDGSKFHSLDDIYYFGGQQAHEVVAIEDHVAQNNQEIDLKVGDKVGIAGNHWNGYSKGTNRRTYKEGVFPSYKVVNDWRRFNFEALLD
The following text describes a protein:
Function:
Catalyzes the oxidation of 3-hydroxyadipyl-CoA to yield 3-oxoadipyl-CoA.
Sequence:
MMINVQTVAVIGSGTMGAGIAEVAASHGHQVLLYDISAEALTRAIDGIHARLNSRVTRGKLTAETCERTLKRLIPVTDIHALAAADLVIEAASERLEVKKALFAQLAEVCPPQTLLTTNTSSISITAIAAEIKNPERVAGLHFFNPAPVMKLVEVVSGLATAAEVVEQLCELTLSWGKQPVRCHSTPGFIVNRVARPYYSEAWRALEEQVAAPEVIDAALRDGAGFPMGPLELTDLIGQDVNFAVTCSVFNAFWQERRFLPSLVQQELVIGGRLGKKSGLGVYDWRAEREAVVGLEAVSDSFSPMKVEKKSDGVTEIDDVLLIETQGETAQALAIRLARPVVVIDKMAGKVVTIAAAAVNPDSATRKAIYYLQQQGKTVLQIADYPGMLIWRTVAMIINEALDALQKGVASEQDIDTAMRLGVNYPYGPLAWGAQLGWQRILRLLENLQHHYGEERYRPCSLLRQRALLESGYES
The following text describes a protein:
Function:
Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage. Weakly binds 25-hydroxycholesterol. Interacts with OSBPL9 to function as lipid transfer proteins. Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane. Late endosome membrane.
Sequence:
MAPGASALGENSTELCSPAQEGQMDLGVKMQGAEPVSTMKVSESEGKLEGLATAVTPNKNSSSSSCGGGISSSSSSSSRGGSAKGWQYSDHMENVYGYLMKYTNLVTGWQYRFFVLNNEAGLLEYFVNEQSRNQKPRGTLQLAGAVISPSDEDSHTFTVNAASGEQYKLRATDAKERQHWVSRLQICTQHHTEAIGKNNPPLKSRSFSLASSGNSPISQRRPSQNAISFFSVGHSKLQSVSKRAPLPPDHLVEVREMMSHAEGQQRDLIRRIECLPASGHLSSLDQDLLMLKATSMATMNCLNDCFHILQLQHASHQKGSLPSGTTIEWLEPKIPLSNHYKNGADQPFATEQSKPVAVAEEQCVAESGLLAREPEEINADDEVEDTCDNKEDDLGAVEEQRSVILHLLSQLKLGMDLTRVVLPTFILEKRSLLEMYADFMSHPDLFIAITNGATAEDRMIRFVEYYLTSFHEGRKGAIAKKPYNPIIGETFHCSWRMPKSEIASSVISSSSTQAITNHAPVSEEALSQVGSDCYTVRFVAEQVSHHPPVSGFYAECAERKMCVNAHVWTKSKFLGMSIGVTMVGEGVLSLLEHGEEYTFSLPCAYARSILTVPWVELGGKVSVNCVKTGYSASITFHTKPFYGGKLHRVTGEVKHNITNTVVCRVQGEWNSVLEFTYSNGETKYVDLTKLSVTKKRVRPLEKQDPFESRRLWKNVTDSLRESEIDKATEHKRTLEERQRTEERHRTETGTPWKTKYFIKEGDGWVYHKPLWKIIPTTQPAE
The following text describes a protein:
Function:
Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor. Other substrates include phenylethanolamine, octopamine and normetanephrine (By similarity).
Sequence:
MSGTGQSHAADAAPDSDPGQAAVALAYQHFEPRAYLRNNYAPPRGDLSSPDGVGPWKLRCLAQTFATGEVSGRALIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELGLWLREEPGAFDWSVYSQHVCLIEGKGESCQEKERQLRARVKRILPIDVHQPQPLGTGSLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRSGGHLLLIGALEESWYLAGEARLAVVPVCEEEVREALARSGYEVRDLRTYVMPAHLRTGVDDVKGIFFAWAQKKVGV
The following text describes a protein:
Function:
May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
Subcellular Localization:
Nucleus.
Sequence:
MTNNKFECKHCMELLFGKKFILQDAEAYCIPCYEQLFSNNCEECKRPIACDSKDLAYKDRHWHEDCFKCGKCNRSLVEKPFAAKDEILLCTDCYSNTCSSKCFQCKKIIMPGCRKLELEGNEWHETCFICQSCEKPLGTEPLVTKENKRYCVPCFERKFAPRCKSCKKPITAEGITYHEQPWHKECFLCTNCNKQLFGERFISKEEQPYCQDCYHQLYTEKCEACTKPILGSRSLKFEGKKWHENCFVCQSCQNPIGTKPLAIKESKHYCVPCFERKFAPRCNSCKKQERGTNKTGTSSSCVYRTRDRQSVIRPRSLLNPWSRKRMPITTGGLIYRERPWHRECFLCNGCKKQLFGEKFVCKDERPYCRDCYTDLFADKCDSCNKPIADPEGPSYISFQERQWHSDCFKCRKCNVSLVDKPFMTQQKEILCRVCGSKRV
The following text describes a protein:
Function:
Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
Subcellular Localization:
Cytoplasm.
Sequence:
MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIEGFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNREAVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRHCIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQHNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSMLLYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRVAAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCEQMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV
The following text describes a protein:
Function:
Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MRIVAILLLFCLCRAAEPRKSSPGVLRSQGNPSRSHGRGGRRGSSPVKRYAPGLPCDVYTYLHEKYLDCQERKLVYVLPDWPQDLLHMLLARNKIRVLKNNMFAKFKRLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEAFIYTPLLSYLRLYDNPWHCTCELETLISMLQIPRNRNLGNYAKCGSPPALRNKKLLQLKPQELCDEEEKEQLDPKPQVSGIPAVIRPEADSTLCHNYVFPIQTLDCKRKELKKVPSNIPPDIVKLDLSSNKIRQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLIHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYSIHYLYYWLKHHYNVHYNGLECKTPEEYKGWSVGKYVRSYYEECPKDKLPAYPETFDQDTEDDEWQKIHRDHPAKKHRVRITIVG
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation. Plays a role in neuronal migration.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MYVQASLKGSAPKAVGTAQAAQGHGPELPELRSVCTQLSDGRFESLLVFTHSMSEFRIHHDVNELLSLLRVHGGEGAEVYIDLLQKNRTPYVTTSVSAHSAKVKIAEFSRTPEDFLKKYDELKSKNTRHLDSLVYLLSKLTEDKETLQYLQQNAKERAELTANMAAGGSTNFSIPSSTSKISLQELEELRKQLGTVTANSSAQQPLELTRKMLRDKQNKKNSGQPVPVFPSWVYERPALIGDFLIGTALSTDITVPIGTLPLASQESMIVEDLLYVLIGVDGRYITAQPLVGRQNRAFLVDPNLDLSIKELVTRILPVAASYSAVTRFIEEKSSFEYGQVNHALAAAMRTLIKEYMILITQLEHLQRQGLLSLQKLWFYIQPTMRTLEILSSLATSVDKGECMGGSTLSLLHDKTFNYTGDSQAQELCLYLTKAASVPYFEILEKWIYRGIINDPYSEFMVEEHELQKEKIQEDYNDKYWDQRYTVVQQQIPSFLQKMADKILSTGKYLNVVRECGRDVTCPVAKEVIYTLKERAYVEQIEKAYNYASKVLLDFLMEEKELVAHLRSIKHYFLMDQGDFFVHFMDLTEEELKKPVDDIITTRLEALLELALRMSTANTDPFKDDLKIDLMPHDLITQLLRVLAIETKQEKAIIGADPTELTLSGLEAFSFDYIVKWPLSLIINRKALTRYQMLFRHMFYCKHVERQLCNVWISNKTAKQFSLHSAKWFAGAFTLRQRMLNFVQNIQYYMMFEVMEPTWHILEKNLKLASNIDDVLSHHTSFLDNCLKDCMLTNPELLKIFSKLMSVCVMFTNCMQRFTQSMKLDSEMDRLSLEHGTMLGPPTEEERAEETAKKKLTSKLLAEHADNLHLTSGFEATINKFDTNFSTHLLDLLDRLSIYSTNDCEHSMLNIIYRLDFNGFYTERLEHMSAERSQRAAPPPPCAAAPTP
The following text describes a protein:
Function:
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.
Subcellular Localization:
Nucleus.
Sequence:
AGIFQEFMVQEESVMFRINLSVLLDCLTIFGTSSSPGTQTALRMCYRGYGYPLTLFLEEGGVVTVCKINTQEPEEILDFDFCSTNVVNKIILLSEGLREAFSELDMTSEVLQITMSPNKPYFRLSTFGNAGSAYLDYPKDSDLIEAFHCNQTQTNRYKIALLKPSIKALALSCKVSIRTDNRGFLSLQYMIRNEDGQICFVEYYCCPDEDITEQEI
The following text describes a protein:
Function:
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MHSPPQQQSFSRLKVEDALSYLDRVKQQFCTQPQVYNDFLDIMKEFKSQTIDTPGVIARVSHLFHGHKDLIVGFNTFLPLGYKIELNKATDTISIYQPESSRTHHHHHQHDVNMDSLPPMITDSVTGQPVEFNHAITYVNKIKHRYQNRPDIYKSFLEILHNYQNEQRISKEQPNAALANKLMEGEVYKNVAVLFADQPDLLQEFSQFLPDASGGGTQNPAHTISNSGILNSVPGSGSFGCGLPANQGTASYMQQQQLQQYNNSSNISSSNSANESGLLSLCSSTISKKSSAAAAATATSSVATAAANQASLPSAVAAAPANNSSSYNNNNMCGSSSNNNVSGSSGTVAGSRKKRFGSGGNLSNAVSSRRFKSDTYSSSSNNNNNNNSSSNAINNTNNNSNNNNNNSSSSGTASQKHMSELSRYGSLGDFAFFDKVRSSLGEHMYHDFLKCLKLYNIPDMKMSSAELMQMIHPFCLKMPELKKRMRVLLNQKDETLPSSSSSSLLPNNSNNNYNSNNYNNNYNNASGNSNNLDGIMANGGFVRSRVGEYAGEIDYASCKRYDISYLSLPKDHIHARCSGRTAMCYEVLNDTHVSFPSWSEDSSSVIKKTMAEEMIFRCEEERYQLDIILENMQSTLDVMRFVQWKMENMTCDERSKFKLDANLGGRSECLHRKTIQGLYGNAASTIVEALRNKPSVAVPVIIRRLEDKVAEWREAKAKNSLAWNEQNQKYYLKSLDHAGLNFKQLDSKLIRSKTLLLEIENNYEKEGTPPHLTLPYNNEMTFVSDAFTLTIHNVKRQSNIHHNEKKKMKQLLQAFLPDFFAFPREAMSDDEVDENASQKDFNGTTASEKISNKNNNNNNSNNNNNNNNQDSQSRSFFVNQNWYIFMRLHFLLSDRLRQFSSHAQKMVKDREVENQMPFVQSTAMSLGLRGAPPDPANSYSQLLKLIISYLDGHIEAPAYEEQLRELFLTNAYVAFTVDKLIQNIVRQLQHIATDELCIRLAELYNNESKSSTSQGAEFELAYQKKAERLLAGDNCYKLFIVSWFSGLWVAISVSLIGSSDCFIVLDG
The following text describes a protein:
Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.
Sequence:
MRRRPCRHTHEAAGNADDSPNSVDKTEDLTDSFSSLSCAAIEHDEYKYSDRKHSDHILAGLNALRSSGAFCDVRLCVEEVEYPCHRVVLASCSPYFKAMFSNEMAERTQNRVVLNGVEADTLRDLLEYAYTSKITISRTNVQSLLSAANLLDIGPIRETCCSFLEHHMDQGNCLGIHRFAEIHSCTDLQEKARDFACYYFTQVMRQDEFLQISANKLAEFLSSDALMVEKEELVFEGLLSWYRHSPDTRKEDFERILEHVRLPLISPYYLNDSVATVAVISQSPKCRELLEEAKSYHLLPDRRRERHHQRTVPRGQASMTEVAVLVGGEDEKVVLRNVDCYVFSTNSWLSLASLPFAVSKHGVAATGHNFLFMVGGEFPDGSVSKATWRFDPALNVWNELAPIETARSELGVATLDGLVYAVGGWDGSARLSCVERYDPSSNFWETLESLKTPLTNPALASLDGRLYVVGGAVLDDGDGVDLVQCYDPKTDAWTKLAPMLISRSGAAACVFNGRLFVIGGWHASYENTNKVECYDPKTNSWEFRKSMKERRYKPGAAVVGRRILVFGGEESWDRHHVSMEAYDPEADRWCDVWDMPLKRSWLGCATVSLPIHMLGGDKTWSDPDEHC
The following text describes a protein:
Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MGANKKKRNFSAVDSSNQPNKKSTMTQSAADQAKEKLPHIMPRKRFYRQRAHANPFSDHNLDYPARSEEMDWSKHYPHFFQAPNSQTTIDHKEEGGEEEKNGVCTALADSSKKVVEFADVGCGFGGLLVAMAPLFPEKLMLGLEIRPHVCQYVEDKILALRAQQKIIQQQSSSTGEGTESVFELPSLPKSVPQNDKQIEQDADPVTNQASNEVTPDEELDDEAPIWVPKPGRFENVSVIRANAMKFSPNFFRKHQLSKMFFLFPDPHFKARKHKARIISPTLLSEYGYILRPNGIIYTITDVKDLNVWMVKHLSEHPLFKPIAVDELIQADPLEDQLIKAIYNLTEEGKKVARNKGDKFLAIFRRISQEEEDALLLS
The following text describes a protein:
Function:
Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR).
Sequence:
MDQDYERRLLRQIIIQNENTVPCVSEMRRTLTPANSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEHKGLFTYSLSSKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNADQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MNGSMALSLVLLVASSLSTRVGADSAEATNANNAVTNACQEAELLQHLIEETESRISTVTTAEDGITEEAQKFFLGAARSAGTDRHWQYLALNLAATQIATNNKAKNKATAATLKDVLQTLLRRQAQVELYHKMSDGAEHKNGISKAKGGQTPLLTAGSSRMCVVEFAAKDPNSQRCRKPVSATKDIDKIRQNVAAADGIKGIPDGAFKRPKITAIAEATGSPDGDNPTASQPICNSGGNGNAGSNNVLAVSAIKLDNSEATPTKATISRPPASATGCKEPEVAPEELLVTQAAVAHSLCKLQTAIPTKAATIGQLTVTALQDNPTVQEIAMLVTGAPNGASDTNTMKAAVKTLFGESTETVQKTYLEPLATVSIQFKVAGTSKEGTIVSFATDSGYSEALAYLLGQDFKASKVKQAQATTAAKPEIEKCKEDTEETKCTEDADCEHKGGKCKLKEGVKVEENEGKGTNNTGSNSIVINRAPLLFAFFLL
The following text describes a protein:
Function:
Catalyzes the condensation of two acetyl-coA molecules into acetoacetyl-CoA. Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds that are building blocks of archaeal membrane lipids.
Sequence:
MRDVAIIGYGQTKFGELWERSFRSLIVEAGVKAVEAAGIDGKDIDEMYVGNMSAGLFVGQEHIASLIAEHAGLNPIPSTRVEAACASGSLALRQAVLNVASGASDVVLVGGVEKMTDVVDATSAISSASDQEWEALFGATFPSLYAMMAQRYMYEYGLTLEELSMWSVIMHENASKNRYAQFPFKVTLEQVLNSSPVAEPLRLLHCSPVSDGAAALIVCEAEKAKEFVNKDDIIYIKASVQASDTIALHSRESITSLKAAKVASEKAYKMANIEPKDVDVAEVHDCFAINGLILMEELGFCKKGEAGKIVYDKKIAIDYDGFPAVNPSGGLKAAGHALGATGIRQVGEIYWQLKQDKEVKDRQVEIKNGYGITVNVGGTGGTVCIHILSDKR