lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Also plays a role in regulation of filamentous growth.
Miscellaneous:
MISCELLANEOUS: Present with 2490 molecules/cell in log phase SD medium.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein. Note=With the VPS34 PI3-kinase complex I, localizes to the vacuole-isolation membrane contact site (VICS) during isolation membrane (IM) expansion. The IM is a membrane sac generated from the pre-autophagosomal structure that ultimately expands to become a mature autophagosome.
Domain:
The C-terminal domain called the BARA domain is dispensable for the construction of both VPS34 PI3-kinase complexes, but is specifically required for autophagy through the targeting of complex I to the pre-autophagosomal structure.
Sequence:
MKCQTCHLPLQLDPSLEGLSLTQRNLLLSNNSIITATNENVISNKGIEAADNCGPQIPKERLRRLGEIQNIKDLNLKDDKLITDSFVFLNHDDDDNANITSNSREDQRYGNANGNDNKKANSDTSDGTSTFRDHDEEEQEATDEDENQQIQLNSKTLSTQVNAMTNVFNILSSQTNIDFPICQDCCNILINRLKSEYDDAIKERDTYAQFLSKLESQNKEISESNKEKQYSHNLSEKENLKKEEERLLDQLLRLEMTDDDLDGELVRLQEKKVQLENEKLQKLSDQNLMDLNNIQFNKNLQSLKLQYELSLNQLDKLRKINIFNATFKISHSGPFATINGLRLGSIPESVVPWKEINAALGQLILLLATINKNLKINLVDYELQPMGSFSKIKKRMVNSVEYNNSTTNAPGDWLILPVYYDENFNLGRIFRKETKFDKSLETTLEIISEITRQLSTIASSYSSQTLTTSQDESSMNNANDVENSTSILELPYIMNKDKINGLSVKLHGSSPNLEWTTAMKFLLTNVKWLLAFSSNLLSKSITLSPTVNYNDKTISGN
The following text describes a protein:
Function:
This protein is a repressor of division inhibition gene dicB.
Sequence:
METKNLTIGERIRYRRKNLKHTQRSLAKALKISHVSVSQWERGDSEPTGKNLFALSKVLQCSPTWILFGDEDKQPTPPVEKPVALSPKELELLELFNALPESEQDTQLAEMRARVKNFNKLFEELLKARQRTNKR
The following text describes a protein:
Function:
Catalyzes the epimerization of L-Ala-D-Glu to L-Ala-L-Glu and has probably a role in the metabolism of the murein peptide, of which L-Ala-D-Glu is a component. Is also able to catalyze the reverse reaction and the epimerization of a broad range of other dipeptides; is most efficient with L-Ala-D/L-Phe, L-Ala-D/L-Tyr, and L-Ala-D/L-His.
Sequence:
MSRIVNVKLSLKRYEYEKPFHITGSVSSESRNVEVEIVLESGVKGYGEASPSFRVNGERVEALLAIENAVREMITGIDVRNYARIFEITDRLFGFPSLKAAVQFATLDALSQELGTQVCYLLGGKRDEIETDKTVGIDTVENRVKEAKKIFEEGFRVIKIKVGENLKEDIEAVEEIAKVTRGAKYIVDANMGYTQKEAVEFARAVYQKGIDIAVYEQPVRREDIEGLKFVRFHSPFPVAADESARTKFDVMRLVKEEAVDYVNIKLMKSGISDALAIVEIAESSGLKLMIGCMGESSLGINQSVHFALGTGAFEFHDLDSHLMLKEEVFRGKFIQDGPRMRVKDQ
The following text describes a protein:
Function:
Required for 3' polyadenylation of the 5.8S and 25S rRNAs as a prelude to their degradation in the exosome. Involved in the nucleolar organization to ensure faithful chromosome segregation during mitosis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKKSVSFNRNNYKKRKNERTEPLPRRIFKNDKPSKFKSKRKEKDKNSDAYDEMLLNNNFTLLDQEEPMVEIGSKKSRNDNDSEGIRDKGGVEISNKNDPYIQFGKADPLEPLEKPDLPEEAIKRGEPTILLGIPKREGRKTNPVHDKAVENNSDFIKFDWNSDEDEDSVSNDKSKNNESLKKSSKNEIPGFMRQRGRFFHEANEKSDSNRKRKRQAYELDSQSCPWHRQYKVEREVSRIFHQDILHFIDYITPTPEEHAVRKTLVSRINQAVLQKWPDVSLYVFGSFETKLYLPTSDLDLVIISPEHHYRGTKKDMFVLAHHLKKLKLASEVQVITTANVPIIKFVDPLTKVHVDISFNQPGGLKTCLVVNGFMKKYPALRPLVIIIKHFLNMRALNEVFLGGLSSYAIVCLVVSFLQLHPRLSTGSMREEDNFGVLLLEFLELYGKQFYYDAVGIAVHNGGFYFSKKKMGWLKPNQPYLLSIQDPVDFQNDVSKSSRGLLRVKATFANGFDLLTSKLYALASRIEREGVNRVKDFPSILSTILSVDEGVRQHREHMLKCYKNNPVPLEPLVEVDALASIDVDKLPLQDVGLQYVEDESDSDETDAAKDDLFKVNESIETNGHENFQKQALTSTGEQSSSNSRANPSKLFNISSDDSEDEVPIIEDTTASDEESRAKKIRKRF
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MPGPSSSAERSAVKSFCDMMHTTEEVAISCLSPVGYDVEEAIDNYYQSRNTTLGGTHWHDKLFEHEHLFGDQHQQRCDETSVRNLFERYANDPLDSQPDRIGPHGVARLLRDLSLDAEDRRVLVLASKMEAQVMCEFSLPEWLKGMQTLNTIFRFTKNAIISVQPVYQFAFGYGKKAGHRNLDLDIALVYWRILFQDQFPLLSLWEEFMTAQGKPVTRDTWNLLGEFAATFSEDLSDYDEDGAWPVVLDKFVTWARPRVSEMGSNYKNI
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MFSAPPATINGADNYISPDPLTAREFGEAEMETILDGDDTELPEITLPGAPIPEGQVEEWQKSRNMGFVMDPVIARGIAWFDAKPGQDGHATKEDRTLYPTTTRVGDEWSDNYKGFVAEAFATTLGPQAAEDLTQRFADFIESIKHYREEIRKDVDIVEAEPLDDAYSIALCIYAVYFHNGAAGQSGFFGSQSTYEVRQPLVEWVNVSEQQPSVELGKEVMSQTPPVQHKDFWKYIYQLVCRGMLKQASHCLHNSGAGEVDPSCQETLEQTIDILSRYPQGPGNVSFYFRQWHNSISTVQSKLLKINDAKIQKGLTTLLQVLAGDEDAIMGTNHTWYDALVTQQQYVDPCDSRMKGYYDAAVANYPVDTFTVWEAGASHAIKGSLLLAIETLENCDSVIAALVSNMCYDAGLLNGYGAANPAALPDYHLTNLALQCIGYDNLINVGIEVLQKLRDVAPARQILSLLLPRLPYDSAREIDWAIKKCKQNGLVEVEAEILQTLAQKAIHNNNNLMGLCMFAKNGNIAALRYHCWKLFKNALVAESPVEGDKSLADYVKDPASVSDVPAEVAECIAPYAVLTEYFNLRRSGQLVKSSEYLLALFEFPLLPTEYLGLLIHQLINYVSPISQQFNFSTSQFMTLLSAFDKWDKSQGTPAFEQGEELIKDMVDHSSDQNDWRKTFKIHELVMSELRLARTSVATMSSLKGLGGR
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MGFPSPSSPEKSPGTILLGKYELGRRLGSGSFAKVHVARSIEAGELVAVKIIDKKKTADAGMEPRIIREIEAMRRLHNHPNVLKIHEVMATKTKIYLVMELAAGGELFTRIRRSGRLQESAARRYFQQLASALTFCHREGIAHRDVKPQNLLLDKQGNLKVSDFGLSALPEHRSSTGLLQTSCGTPAYTAPEVIAQKSYDGAKADSWSCGVFLFVLLAGYVPFEDSNVVTMYRKIQRRDYKFPNGISKQARSIIYNVVESNQPEIKINAKQSQL
The following text describes a protein:
Function:
Acts as a key regulator of trichome branching. Could participate with STI in the same pathway. Also plays a role in integrating endoreplication levels with cell shape.
Sequence:
MKDMKMQSSPETMMTRIPTPDPHSTGVREDAMDSVCKPWKLYENPYYCSSQSQQHQHQRKAFIWDLNFIKVFMESELGKAQDEIKELKAELDYERKARRRAELMIKKLAKDVEEERMAREAEEMQNKRLFKELSSEKSEMVRMKRDLEEERQMHRLAEVLREERVQMKLMDARLFLEEKLSELEEANRQGERERNRMMKPKILERACSSPARRRCENPQIKRGINPFPRVMRAIRSKSEKWGSKLECQKVQLKILLRQKTTPRCTPLLSSPPP
The following text describes a protein:
Function:
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.
Subcellular Localization:
Nucleus.
Sequence:
MTTLKTILGGPLAPDHVSDLSNNLVVVLHQIYNANALTTADENTLHKFRVRVSAFLKSNDSRQRWCGAFLALAAVQNSWECLKNHGATWLGMLIHILELPEAPATWEMALRASAEMLALVSQKTELTREIATSRIAPLSKAALAILESPENCSPSTAAVFVSELQRVNVAHPVGFRPHSKRFQSALIRLIATSPDSKLVQKACDALTVAHYSASNFGEAAEWREGCLSTISDIHIAVNALLEGRTDDALASVEQTKSWGFDTKSGSSPADIYASAKAIENLYTLLTAFLSQPTAVPVKIPVGRIIPLFNRVTSLAQVHFKAHVPLVEQNLVRSTFERINIAAMQSLSALINTVGANISAYVEDLLETVDMISADNSAVTLAALDLLTTIFNNVGYISAGSSVQEYVEKAVSQALVLITPGTNVSQAGQTEIPDYISKSHLFESPISHITQQTVYTFLEATMLVCDLSGRCRGLIDRTLLLSKHAARRSAAVTSALNPSMASKHSILAMVQQQYPRDTSISRFVHPRLPPLTTERRYLPVSSSLGEEEELDEEMEIEEEEETSGIEPVSASSAPVTTNTFASTAFREPENPVVVDAPFEPLPETMAEPVQAIERPSNIEPTTEFEEIEEEEVAENQVDDSDEEMGSDFEMPALDVGDSDDDE
The following text describes a protein:
Function:
Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity).
Subcellular Localization:
Mitochondrion.
Domain:
Contains about seven structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a superhelical structure with a solenoid shape (By similarity).
Sequence:
MAVWARQVARCGWLRAAGLLGLRSRSGAARACCGAAPLPALLSGHRLPPWRLRVSVDYAQPSRAKGEACAPRSSLPVAVKQEQAAPETVSDLSAAKLCEDWDDVPPSSALEEISEEEAVKIIADPLLPPQSSTLRDYVDHSETLTKLVHLGVDLSQVEKRQKAGQLLLTLDFEKDITKILLFLKDVGIEDNQLGPFLTKNPYILGEELEALETRVAYLKSKKFGNAEITQMVSRAPYLLLFSVERLDNRLGFFKNELGLSVKKTKDLVIRFPRLLTGKLEPVKENLQVCQVEFGFERNEVQQIAFKTPKILTASKKRLRQTFDYLHNIMGIPHNMLTRFPQVFNSKLLRIKERHMFLIFLGRAQYDPTKPSYISLDQLVSLPDEVFCTEIAKASMQDFEKFLKTI
The following text describes a protein:
Function:
DNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance. FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (By similarity). Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Sequence:
MLSKEALIKILSQNEGGNDMKIADEVVPMIQKYLDIFIDEAVLRSLQSHKDINGERGDKSPLELSHQDLERIVGLLLMDM
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGVWSVLFMSAMPVFRLLVHCGIGAYLSSPQSNVMPAEARKHINKLVFVCFMPSLIFSNLAQTVTVEKMLDWWFMPINVLLCYMIGAGIGVCIFDHFKPPPHLRKLIIACCATGNSSNLPLVLVSAICVEAGSPFGRYDVCTANGIAYISYGLWMATVLTWTVNLQGMDSFQQGYQGFQAPQMFQVPGQGYQQQAFSAMTQGPRGFQAGPRYSQGFEDYNDGFIGSQPQGFLPSAQAFPTRGRNPSIGLGDFQQFQSPQAIAIPIGAVPFFRHLLYGHQAPFRFLGDALVILGEAMIPCMNLLLGGNLSQAGFGASELALEVVISIMLTRLLLLPIAGLIVVKLAFSMGLVPADPLFHFVLLLQFTMPTAINVGTMTQLFGVGQTECSIILFWCYTSSVVFLTLWTMIFLVLLI
The following text describes a protein:
Function:
Component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations. Required for the adaptation to the presence of glucose in the growth medium; mediates in association with the substrate receptor VID24/GID4 the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium. Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1), malate dehydrogenase (MDH2), and other gluconeogenic enzymes.
Miscellaneous:
MISCELLANEOUS: Present with 1200 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSHTNKIAYVLNNDTEETASPSSVGCFDKKQLTKLLIHTLKELGYDSAANQLLLESGGYQNESNHIQTFFKLIKTGQFHLINWQIVCSLPLAHSSPLRSEWLQRLLIPTPTPATTSLFDHMLLQLQYLQQLMSSVNSSTCSDAEIATLRNYVEIMILVNRQIFLEFFHPVTNSASHKGPHTALPVLYLRKILKNFIEIWDSLLVSNDQFLNEENIFNPETTLRELSTYLTNPKLTAQLNLERDHLIDAISKYIDPNELVPKGRLLHLLKQAIKYQQSQDIFNIIDPDDDASFSSPPHRINLLQDNFSHDLTVTFQEWKTIQDTTDEIWFLTFSPNGKYLASATSESSRGYFITVYDVEQDFKIYKTCVSLSQSVLYLMFSPDSRYLVACPFSEDVTIYDMNATSLPDASATDSFLLYPSTRLSPMDSFKLDTTTYPDDTESSASSSSRPANANSNQSRVWCCDAFHTAERAGWMVVGSPDREAIVHSLTTKESLFSLKGRTCIALGHDENISGRKSIDPAKVLYKPTSSNGNWQYVEDDETFPRVHDVKISYDDKYVLLMTHQGVIDVYDFSGFPSKEELSKQTVDPKNFLIPRIARLDVGKNMTCISLPLNTTHQGFHRQQISESQHLVLVSLQDNELQMWDYKENILIQKYFGQKQQHFIIRSCFAYGNKLVMSGSEDGKIYIWDRIRGNLVSVLSGHSTVMSNSTKPMGKNCNVVASNPADKEMFASGGDDGKIKIWKISRN
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MIELTPIQYSKGKKGKFNEGSISLINNKIICLKKEKEEFTIDIQKSVLIRNGDLMKKLEEQQVNKSFQINTEKENYIFLFNDFGKFINWLTQLGLNMKISGTYGYPLRVACLKSGWRYPVPFFRSIQYLRYNGGITTEGIFRVSPSRDEMMAVKKILESDTTSQPIDFGNVRIASAVCKNYLSSLDDPIIPYFRYDEFVKCGRCVDKKERIKQLRKFVESLPSINKNCLWYLIDFLHLISINKAINLMGPMNLAVCFGPACVRNPDLTWEQSANDLNLIQNAFELMIESYEQIFKHIKEENEMI
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in ribosome assembly.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MADDFITTIDSDDEVSNYGEPSALPKIKDDELDPDFQFDLGGGRSEGLDLWGGDEVQGVKKGNEPINVDDIIERKRGKPIRAFKDRKRKRDEDATSEDDLEEDEEEEGDSNDDSDAAKSGDSEEDEMDVDMSEGDGDEEDENEIESLKREDESDEEEEEEEDDYDEEGENEVVDSDSESEEETAAEIARKDAFFSSDPTTTDPTLPSSFTAMNLSRPLLRALTSLQFTAPTPIQARAIPLALLGRDILGSAVTGSGKTAAFMVPILERLCYRDRGKGGAACRVLVLCPTRELAVQCEAVGKALAEKGGLDVRFALLVGGLSLNAQAHTLRTLPDILIATPGRLIDHLTNTPSFTLSALDVLVIDEADRMLEAGFTDELEEIIKACPRSRQTMLFSATMTDSVDELVKLSLDKPIRVFVDPKRNTARGLTQEFVRIRSDDSRSPSLLALCKRTIREKCIIFFRSKALAHQMRIVFGLFGLKAAELHGNLTQEQRLQALNDFKAGTVDYLLATDLASRGLDIKGVETVINYDMPGQLAQYTHRVGRTARAGRKGRSVSLVGEADRKMLKAAIKQAEADQVRHRIIPSEAVTAMKEKLEEFKDDIQEILKEEKEEKLLRQADMEIKKGQNMVEHEAEIFSRPARTWFQSGKEKQASKSAGKDAYVGSFPSTGKSAEKEKEKLKRGKYDGLSRRLKRRKMAIEEDAADAAAARKTEMGIRAAKKNALPKKITEPQPRLEKAGKGKDKKKGKARRVTGGKGSAFDSEGKKSHEGMRAKPAKVNLEKGKKKGGKGKGRK
The following text describes a protein:
Function:
Involved with PTP2 and PTP3 in the formation of the polar tube through which the infectious agent is passed on to the host cell. Accounts for at least 70 percent of the mass of the polar tube.
Subcellular Localization:
Spore polar tube.
Sequence:
MKGISKILSASIALMKLENVYSATALCSNAYGLTPGQQGMAQQPSYVLIPSTPGTIANCASGSQDTYSPSPAAPTSPVTPGKTSENETSPSAPAEDVGTCKIAVLKHCDAPGTTSGTTPGSGPCETPEQQQPLSVISTTPAVPVTVESAQSPSVVPVVPVVAHHQAVPGYYNNGTSGIPGQQQILSGTLPPGATLCQGQAMPSTPGQQQILSGTLPPGVTLCQGQATPSTPGQQQVLSGTLPPGVTLCQGQATPSTPGQQQVLSGTLLPGATLCQDQGMPGTSGVPGQQGQSSGQCCAPQIPNPVMPPSMNISGNGYPSSTAYSPNLGSLGSCVDIQKTGGTSCEQKPEKSATQYAMEACATPTPTVIIGNSEYLVGPGMYNAINSPCNTAVQCC
The following text describes a protein:
Function:
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).
Subcellular Localization:
Cytoplasm.
Sequence:
MTLFFVCPQDTIFNEIDLQDVSVAECSIRNVNNSFTVITPFRSLVLCADSRQEMEEWLGCLKSSNKKRSSQSDLLDQISGLHNWYSCAHARPTFCNVCKDILSGVTSKGLSCEVCRFKSHKRCAAKAPNNCKWTTMQAIRKDNEDCDNSDPMSMPHQWLEGNLTPGARCTVCERPCGSKRRLLDFRCLWCNMTVHHSCKLSVVSKCTLGENSLSVLPPMFIKGLSELAKGEVVKPRNSPLLVFVNSKSGDNQGVKFIRKFKQLLNPLQVFDLGVGGPTNGLKFFRRFRRFRILVCGGDGSVGWVMKEVDLMKMATQCQIGVLPLGTGNDLSRVLGWGTSFADENSVPQFLQHLERAKPLMLDRWAIMVQECNPTLPSSRSSSIEALDTPVRVMDTFESNVATHLTRILHSSQHTIVISSAKVLCETVKDFVAKVGAASATTEPDAADSLASKCSVLNDKLNLLLKALSIESEASSTPVKEDLADMKSGSSGSINSIGSGGKAQKVFVPRDALMSRANSLKKALKQIIDHTEIDTSSFSSSPAPRADIRFLSKGSSHPFQPREGLMGSMISKALLANADALCAAATPVMNAVSDVDGFSEKCVMNNYFGIGIDAKITLDFHTRREEHPEKYRSRTRNMIWYGVLGGKEIVQRTYKNIDQRVKCDGHRISLPSLQGIVVLNITSYMGGANFWGGGRDDGFTDPSFDDNILEVIAVLGAKQM
The following text describes a protein:
Function:
Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. Required for the oligomerization of SNF7 into a membrane-associated filament. The VPS20-SNF7 subcomplex is responsible for the membrane association of the ESCRT-III complex. Also required for the RIM101 repressor proteolytic activation.
Miscellaneous:
MISCELLANEOUS: Present with 937 molecules/cell in log phase SD medium.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Sequence:
MGQKSSKVHITKTDRAILEVKRSKDEIHKFTRRTDNLILVEKSQLKDLIRKNPENYKSNMKVRFLLKRIHYQEHLLQQASDQLINLENMVSTLEFKMVEKQFINGLKNGNEILKKLNKEFSNVDELMDDVQDQIAYQNEINETLSRSLVGTSNYEDDLDKELDALESELNPEKMNNAKVANMPSTEGLPSLPQGEQTEQKEREEFATEERSDTKEPLALLS
The following text describes a protein:
Function:
May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.
Sequence:
MRNCRKPANCSNCACRSSSQISEDPDDGCMELWCQNLRRWVVKMRKDVKKVKVLIIRKLTRHIAKLKSKKGTEELTLKNQRRAQRLLEEIHSVKELKPDDVTKTALRKEISFEKVFKKPSSTTEERAIARLATHPLLKQKITAIKEAVKAFKEARKTASEGEKEKEKDEPMQVTKIKETKKPVQAKQNKNAIKKEIPAPKQHVKEVRCKNLQEDSDKSNENACEPPHVQENMPADTPPIAENKEQPKAQEVESPEVESPEVESPEVESPVVESPVVESPVVESPVVESPVVESPVVESPVVESPEVDCPDIECPEMESPPQKKACLEQVLSSDSSDIEDSEQEKEYFDDSTEERFYKHSSSFEDSDGDSDNDFFIGKVRRTKKKKSNKDGIKQKEEKAPPTKDVAQTSEVQKEIPTSKSMKLQSVFCKSLSHTRPKPSFTKRERNFPQERSKKTVAPQANPLAKKPFQSKVTSVKQQGKKSELQPLHPSWEASRKRKEQQAQITTFQGKKIIFDD
The following text describes a protein:
Function:
Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLEAPGPSDGCELSNPSASRVSCAGQMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAMGYEVDTSSAIYKQYRLQKVTEKYPELQNLPQELFAVDPTTVSQGLKDEVLYKCRKCRRSLFRSSSILDHREGSGPIAFAHKRMTPSSMLTTGRQAQCTSYFIEPVQWMESALLGVMDGQLLCPKCSAKLGSFNWYGEQCSCGRWITPAFQIHKNRVDEMKILPVLGSQTGKI
The following text describes a protein:
Function:
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
Sequence:
MLDFDLVLFGATGDLAMRKLFVSLYEIYTHYGFKNDSRIIASGRKELSNEEFLTLLCEKTQLHSREKGREFLAHISYLCVRLDNPKDFEELSKIATKNKPLIFYFSISPSFFATTAQHLAKNALNHANTRLILEKPLGHDLKTCKEIFQSISVFFKEEQIFRIDHYLGKKGVQNILELRLNNPILNILWDQISAVEICVYETLGVEERGEFYDKIGALRDMVQNHLLQVLSLIATDLPNNLKDLRKEKIKVLKTLQPPKDFKKQVIRAQYQGYRDENKVHKESQTETFVAIKAFLDTPKFKGVPFYLKHAKKMPHNQASVKIHFNAVNTLEFFLSQDKITLTLKDHQNPLILETHNKQEFLRPYAKLLYDAIQNNHNNFAHQLELEASWVFIDTLIEGFMNNATPLYSYESHHLNESEFLKPLYQ
The following text describes a protein:
Function:
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability (By similarity).
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore.
Domain:
The entire WD repeat region is required for the interaction with ORC complex components, as well as for association with chromatin and for binding to histone H3 and H4 trimethylation marks H3K9me3 and H4K20me3.
Sequence:
MEKITEKILLEKSSTKTNKLDQIKTLNLSRMSLKSEDLPVPLLSKLCRLEKLDLSGNMLQKIPKGLRLPCLKILNCSNNDMEDVLSLEALTNLEELRLEDNLYLTVNDEHKVIFLLPNLRMFNGKDISSTAHHIRHGSTEILRKRVIGVWERDFSLPDPISAKSLAAVEKSFVNAACTQVKYGPNSLSDYTKWRVEKIAKEYLKSLTSSEEEERVADTTPTKENKTKACDVGGNSITSPQKRTRNNTDVVAEASPRKSSRLVSAAPVEASPRKSARVLNTPQKTQPVVSSPRKHARLTSAETPESSPRKSSRLENVTQKAASQTESPRKPGMSTPTSKQAKCESPRKQSKQSTAKMEKSTPRKTTKAKLQVPQEPVSLTPLHVLQCHSRQNDPDDFSTQLWACAFEPQQDDSIDISGGSQTIATCGGETLCVINCESGLVLKKYKVPGEDFFSLAWSTVLMSRTGGSARPCNILAAGGKRGCVKLIHPRVNLAFGEFRVSRRAISIMRFNPRKPTFLFTGTYDKKIFLWDIGGLDQDYNFKISKLLTLETSSTPLHLALLPSSPDTHLLSGCDEGLYCFDVQLSKNTLKRNEEIEIVFPIYKKNDKKNNYRTIDGLSFLSDDVVASKSHMQGSIYLWSWSATRASWNSRKKEVPAVILAELQWSSTDIPYLSLGTCPGYGYVVCGDEQGRLWMYHITDTMMENFKSGKTISATEVLQWPSPIRAGKGALEGPSINSTAMDPGLHYLVALTDKNMVVVWKRESH
The following text describes a protein:
Function:
Positively regulates the expression of the exporter LysE and represses its own expression. Activity requires the presence of a coinducer, lysine or histidine. Acts by binding to lysG-lysE promoter region. Also up-regulates the expression of ppsB, ppsC and ppsD, by binding to the upstream region of ppsB.
Domain:
Contains an N-terminal DNA binding domain (DBD) and a C-terminal regulatory domain (RD).
Sequence:
MVDPQLDGPQLAALAAVVELGSFDAAAERLHVTPSAVSQRIKSLEQQVGQVLVVREKPCRATTAGIPLLRLAAQTALLESEALAEMGGNASLKRTRITIAVNADSMATWFSAVFDGLGDVLLDVRIEDQDHSARLLREGVAMGAVTTERNPVPGCRVHPLGEMRYLPVASRPFVQRHLSDGFTAAAAAKAPSLAWNRDDGLQDMLVRKAFRRAITRPTHFVPTTEGFTAAARAGLGWGMFPEKLAASPLADGSFVRVCDIHLDVPLYWQCWKLDSPIIARITDTVRAAASGLYRGQQRRRRPG
The following text describes a protein:
Function:
Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.
Sequence:
MGSPLGCGWESEGLLVQPLPTIDAHTRALNQGSPLIIIGGAEDKEREKSILKAFLARAGGSEARLLLVPSASSMPEILAEVYRLLFVQLGAASVEVLNITNRFEAELDENVARLHNSTGLFMTGGDQVRLCKLVAGTALARAMQQASTAGRLVIAGTSAGASAMGECMIARGYSGEPPKRNIVELSEGLGLLKDVIVDQHFHNRNRLPRLMTAVASQPHCIGIGIDENTAVVLHGDGILEVIGEGTVTVVDGSELVYNTINDIQSYQPLSVGNFRIAVMAQGLRYNLRERQTL
The following text describes a protein:
Function:
Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Purified ATP synthase is 25.9 nm long. The hydrophilic A1 domain is 9.4 X 11.5 nm, the central stalk is 8.0 X 3.9 nm and the membrane-bound A0 domain is 6.4 X 10.6 nm; the domains are connected by two stalks. ATP is synthesized or hydrolyzed by the A1 domain while ion translocation occurs via the A0 domain.
Sequence:
MVDPLILGAVGAGLAVGIAGLGSGIGAGITGASGAGVVAEDPNKFGTAIVFQALPQTQGLYGFLVAILILFVFKTVSPWAMFAAGLAAGLAGLSAIGQGIAASAGLGAVAEDNSIFGKAMVFSVLPETQAIYGLLIAILLLVGVFKGNAGAETVAALGAGFAVGFAGLSGIGQGITAAGAIGATARDPDAMGKGLVLAVMPETFAIFGLLIAILIMLMIK
The following text describes a protein:
Function:
Essential cofactor of the RNA polymerase L that plays a central role in the transcription and replication by forming the polymerase complex with RNA polymerase L and recruiting L to the genomic N-RNA template for RNA synthesis (By similarity). Also plays a central role in the encapsidation of nascent RNA chains by forming the encapsidation complex with the nucleocapsid protein N (N-P complex). Acts as a chaperone for newly synthesized free N protein, so-called N0, allowing encapsidation of nascent RNA chains during replication (By similarity). The nucleoprotein protein N prevents excessive phosphorylation of P, which leads to down-regulation of viral transcription/ replication. Participates, together with N, in the formation of viral factories (viroplasms), which are large inclusions in the host cytoplasm where replication takes place (By similarity).
Domain:
The N-terminus consists of a long intrinsically disordered tail. The central part contains the coiled-coil multimerization domain (MD) (By similarity). Forms a four-stranded coiled coil structure (By similarity). The C-terminus constitutes the alpha-helical domain (XD) that binds to the nucleocapsid (N-RNA complex) (By similarity).
Sequence:
MAEEQARHVKNGLECIRALKAEPIGSLAIEEAMAAWSEISDNPGQERATCREEKAGSSGLSKPCLSAIGSTEGGAPRIRGQGPGESDDDAETLGIPPRNLQASSTGLQCYYVYDHSGEAVKGIQDADSIMVQSGLDGDSTLSGGDNESENSDVDIGEPDTEGYAITDRGSAPISMGFRASDVETAEGGEIHELLRLQSRGNNFPKLGKTLNVPPPPDPGRASTSGTPIKKGTERRLASFGTEIASLLTGGATQCARKSPSEPSGPGAPAGNVPECVSNAALIQEWTPESGTTISPRSQNNEEGGDYYDDELFSDVQDIKTALAKIHEDNQKIISKLESLLLLKGEVESIKKQINRQNISISTLEGHLSSIMIAIPGLGKDPNDPTADVEINPDLKPIIGRDSGRALAEVLKKPVASRQLQGMTNGRTSSRGQLLKEFQLKPIGKKMSSAVGFVPDTGPASRSVIRSIIKSSRLEEDRKRYLMTLLDDIKGANDLAKFHQMLMKIIMK