lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
Sequence:
MQPQSVLHSGYFHPLLRAWQTATTTLNGSNLIYPIFVTDVPDDIQPITSLPGVARYGVNRLEEMLRPLVEEGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGAFRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRDAAKSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site.
Sequence:
MIPSTGKIDRLLVELRPRLQCANFFISFPRKFVDIESTTIELATDRITIVMKGERERYEIRTGDYFQLHTQTLSSLVIKNRYICFRVNTNESVFGSERLSTGQEMPGSDQHEENFRLACNVQPGQRYRVLCSNCAGPLQQSADPAGDPDTSFQRVLELPSEQLDTDDWFCHRHDHQPSEGAPEPCHGRQQGEPSSQLSTKFEPQPGDLFYGTFYALLHRNVLQRVHVRNDRFVYCKRCLQYLGSTRKNRTSVKLWYENVRFQPSERSAIPLSLFRTDDALELFHHLVRKTVREFNFVTHLGLPPSIKLLFELRRPGMQGDVFYLLMQIMDCQLSVFRAKQKRTGSGSSESCSDDVDDCRADGKEDVAENVALERVDLKKIEHQDEANHDDDEGDDDDDDVFIDNSYRKHTIKLERHRAMKLMYQYEKYDDQPLFVFWREDSNVVNLELSEPMFSAAIRYLDANSSYVPECYRVNLGFSMSYLDIQ
The following text describes a protein:
Function:
Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MPVYVDYDVPADLQERALESLEVARDTGSVKKGTNETTKAIERGNADIVFVAEDVSPEEIVMHLPELAAEKGIEVVFVETQDELGNAAGLEVGSAAAAVVAAGDAEDEIEDISTKVEDLQ
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGSKRNFLAILSVSNKHGLENFAKRLQNLGIDLIASGGTAKKIRDAGIEVRDVSSVTGAAEMLGGRVKTLHPAVHAGILATQSPSDIADMEKHDFKNIKLVICNLYPFVNTVNKPGIQMAEAVEQIDIGGVTLLRSAAKNHAHVTVVCDPSDYDNVASELEASSDCDTKPETKQKLALKAFSLTAEYDAAISSYMRGEYGDKQQLPLRYGMNPHQKPAKVYINNKNLPFQVLNGSPGFINLCDALNSWQLVRELKSSLQLPAAASFKHVSPAEGAAVGNFMSEAHAKLCMVYDLYEQLTPLAIAYAKARGADRMSSFGDFIALSDPCDVITARIIAREVSDGIIAPGFDKEALAILGKKKGGKYCILQMDPDYEAPDLETRMIFGVTLEQKRNSLLFDESMLQNIVTQRKTVPEAATQDMVVASIALKYTQSNSVCFAKDGQVIGIGAGQQSRIHCTRLAGDKANNWWLRQHPSVLGMKFKKGVKRAEMSNIIDVFVNGTVGQDMDETTWKNSLENPPTLLTAAQRKEWIEKLKGVSLSSDAFFPFRDNIDRAQQSGVEYVVSPSGSTQDNAVVAACNEHDMVMIHTNVRLFHH
The following text describes a protein:
Function:
Involved in gametogenesis and steroidogenesis.
Subcellular Localization:
Secreted.
Sequence:
MNTVLFPFWMLFLLLSPVVPMCLPTDFTLYVEKPECDYCVAVNTTICTGFCYSRDSNMRDIFGPRFLIQRGCTYDKVEYRSAILPGCPLESNPVFTYPVALSCHCSACRTDSDECTHRASTGGGRCTKPVRLVHPYPGQSTYMILF
The following text describes a protein:
Function:
Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.
Sequence:
VNMSKQPVSNVRAIQANINIPMGAFRPGAGQPPRKKECTPETEEGAPPTTEEEKKPIPGAKKLPGPAVNLSEIQNIKSELKYVPKAEQ
The following text describes a protein:
Function:
One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization. Required for PSII activity, at least in part due to its effects on PSII assembly. May make specific contact(s) with lipids.
Subcellular Localization:
Cellular thylakoid membrane; Single-pass membrane protein.
Sequence:
MDRNSNPNRQPVELNRTSLYLGLLLVAVLGILFSSYFFN
The following text describes a protein:
Function:
RNA-binding protein involved in the chloroplastic group II intron splicing. Binds specific group II introns and promotes their splicing. Functions in the context of a heterodimer with the ribonuclease III domain-containing protein RNC1.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MDAKLLLPFPFAPAAATRSPKSLFLGAPLPPPPRPPPFPLRLRPRPAAVVAQAAVKRRKEAPFDTVIQRDKKLKLVLKLRNILVAQPDRVMSLRELGRFRRDLGLTRKRRLIALLRRFPGVFDVVEEGVYSLRFRLTPAAERLYLDELRLRNESEGLAVAKLRKLLMMSQEKRILIEKVAHLKHDLGLPPEFRDTVCLRYPQYFRVVRMDRGPALELTHWDPELAVSAAELAEEESRAREAEERNLIIDRPLKFNRVRLPKGLKLTRGEARRIARFKEMPYISPYADFSHLRSGSDEKEKHACGVVHEILSLTVEKRTLVDHLTHFREEFRFSQSLRGMIIRHPDMFYVSFKGDRDSVFLREAYKDSQLVEKNQLVLLKEKMRALVAVPRFPRRAAVGTGEEAEGMNGSLQSRDQVSDEEYDDEDEGLSDMEDLISELSGGKSDADYEWGDGWFGENDDSPPDFGDDEVKVAMKIADGSANGSAPVPVFPDGRPRERW
The following text describes a protein:
Function:
Probable 2-oxoglutarate-dependent dioxygenase that may be involved in glucosinolates biosynthesis. May play a role in the production of aliphatic glucosinolates.
Sequence:
MTKSAEMSSETPVRLPVIDSSKQDLKPGSADWELVKVQVRQALQEYGCFEALFDKVLELGKPLIGALEELFDLPLQTKTRYVSEKVFRGYYGPKAPLHESMVIDEANVAENVEQRLTNILWPQGNSSFSETLLSFSSLASGLEKTIRRMILESFGLEKYMDKHMESTNYILRVMKYEGPHTSEPTIGARAHSDQNMVTLLHQNEVNGLEIQTKDGEWINVKPSPASFIVMIGESLSVWLNGRLPSPYHRVMITGNKARYSSGLFATTKGGYKVKVPEELVDEENPLLFKPFDYEEFLEFYSTEAARGALGSGLKAYCSV
The following text describes a protein:
Function:
5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin. Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem).
Miscellaneous:
MISCELLANEOUS: Was named 'Apollo' in reference to the twin brother of 'Artemis' in Greek mythology. Artemis/DCLRE1C is a related nuclease.
Subcellular Localization:
Chromosome, telomere. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome.
Domain:
The TBM domain mediates interaction with TERF2.
Sequence:
MNGVLIPHTPIAVDFWSLRRAGTARLFFLSHMHSDHTVGLSSTWARPLYCSPITAHLLHRHLQVSKQWIQALEVGESHVLPLDEIGQETMTVTLLDANHCPGSVMFLFEGYFGTILYTGDFRYTPSMLKEPALTLGKQIHTLYLDNTNCNPALVLPSRQEAAHQIVQLIRKHPQHNIKIGLYSLGKESLLEQLALEFQTWVVLSPRRLELVQLLGLADVFTVEEKAGRIHAVDHMEICHSNMLRWNQTHPTIAILPTSRKIHSSHPDIHVIPYSDHSSYSELRAFVAALKPCQVVPIVSRRPCGGFQDSLSPRISVPLIPDSVQQYMSSSSRKPSLLWLLERRLKRPRTQGVVFESPEESADQSQADRDSKKAKKEKLSPWPADLEKQPSHHPLRIKKQLFPDLYSKEWNKAVPFCESQKRVTMLTAPLGFSVHLRSTDEEFISQKTREEIGLGSPLVPMGDDDGGPEATGNQSAWMGHGSPLSHSSKGTPLLATEFRGLALKYLLTPVNFFQAGYSSRRFDQQVEKYHKPC
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAANCTSSWSLGESCNSPGSEPPQSMPSPATQLGNHDSDPETCHVNFRMFSCPKESDPIQALRKLTELCHLWLRPDLHTKEQILDMLVMEQFMISMPQELQVLVMMNGVQSCKDLEDLLRNNRRPKKWSVVSFLGKEYLMQESDVEMAEAPASVRDDPRHVSSQRTSSVNQMCPEEGQASQELQTLPRVPALFRRQEEDFLLPETTVMKGDPKALRPKPTLEKDLEEDREENPGLTSPEPQLPNSPTGVVGAKEGKEPQKRASVENVDADTPSACVVEREASTHSGSRGDALNLRGLKRSKPDATSISQEEPQGEATPVGNRESPGQAEINPVHSPGPAGPVSHPSGQEVKELLPFACEVCGKRFKYRGKLAVHTRSHTGERLFQCNLCGKRFMQRIGLQFHQRTHTGERPYTCDICQKQFTQKSYLKCHKRSHTGEKPFECKDCKKVFTYKANLKEHQRIHSGEKPHKCSKCPRAFGRPATLRRHQKTHREATSQ
The following text describes a protein:
Function:
Involved, partially redundantly with VCC/DEAL1 and DEAL3, to ensure bilateral symmetry development and early leaf margin patterning, probably via the regulation of auxin and CUC2 distribution.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MARNVGFFICILILAMDVSAGILGIEAEIAQNKVKHLKMWIFECRDPSYTAFKYGLAACILLVLAHVTANFLGGCLCVASRQDLEKSSANKQLAVASLIFTWIILAIAFSMLIVGTMANSRSRKNCGISHHRVLSIGGILCFVHGLFAVAYYISATASTREQTSAGHA
The following text describes a protein:
Function:
May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
Subcellular Localization:
Cytoplasm.
Sequence:
MADIIARLREDGIQKRVIQEGRGELPDFQDGTKATFHYRTLHSDDEGTVLDDSRARGKPMELIIGKKFKLPVWETIVCTMREGEIAQFLCDIKVESPGTYQQDPWAMTDEEKAKAVPLIHQEGNRLYREGHVKEAAAKYYDAIACLKNLQMKEQPGSPEWIQLDQQITPLLLNYCQCKLVVEEYYEVLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRALEARIRQKDEEDKARFRGIFSH
The following text describes a protein:
Function:
Probably involved in mitochondrion division process. Binds to and hydrolyzes GTP (By similarity).
Subcellular Localization:
Mitochondrion. Note=Locates to a submitochondrial body usually located at one end of the organelle.
Sequence:
MTILNRFCRTILLTNLELTNCGIRKNNSYKCRSFTHTINIDTNHIVPIHTQSNITLELFQPKISVVGVGGGGGNAVNHMISQSLEGVEFFVCNTDSQDLIKSNSINKIQLGPQLTKGHGAGANPEKGRLAAEESKNKIIQTFKDTDLLFLAAGMGGGTGTGSSPIIAKTIKEFKKETIIVGVVTVPFNFEGKRKEIIAKKGLEELSKYVDTLVVISNQNLLDASKSDIQLEQAFLMVDEILHTGIRSIANIINVPGMINLDYSDVVNILKNRKGLSRIGFGEASGEDRAYKAVHKAIKNPLIEIDDQKFTGLLVNISGGNDITLNEISKTINYLQQNADPDVQVFVGHTVDNSLLGKIRISCLFVH
The following text describes a protein:
Function:
Nuclease that is responsible for viral evasion of host cGAS-STING innate immunity. Cleaves 2',3'-cGAMP which is produced by host cGAS following recognition of cytosolic DNA and blocks the subsequent 2',3'-cGAMP-mediated activation of TMEM173/STING, which normally spreads to adjacent cells and activates the interferon and NF-kappa-B immune responses.
Domain:
The substrate binding site is formed by the N-terminus of a monomer and the C-terminus of the opposite monomer.
Sequence:
MAMFYAHALGGYDENLHAFPGISSTVANDVRKYSVVSVYNNKYDIVKDKYMWCYSQVNKRYIGALLPMFECNEYLQIGDPIHDQEGNQISIITYRHKNYYALSGIGYESLDLCLEGVGIHHHVLETGNAVYGKVQHDYSTIKEKAKEMNALSPGPIIDYHVWIGDCICQVTAVDVHGKEIMRMRFKKGAVLPIPNLVKVKLGENDTENLSSTISAAPSR
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MPQMIPFFFMNQLTYGFTFILTILFLTSYVFLPMILRLYISRLYISKL
The following text describes a protein:
Function:
Catalytic subunit of a polyglutamylase complex which modifies tubulin, generating side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Probably involved in the side-chain elongation step of the polyglutamylation reaction rather than the initiation step. Modifies both alpha- and beta-tubulins with a preference for the alpha-tail. Unlike most polyglutamylases of the tubulin--tyrosine ligase family, only displays a catalytic activity when in complex with other proteins as it is most likely lacking domains important for autonomous activity. Part of the neuronal tubulin polyglutamylase complex. Mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility. Involved in respiratory motile cilia function through the regulation of beating asymmetry. Essential for sperm flagella biogenesis, motility and male fertility. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, flagellum.
Domain:
Gln-144 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate-chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation.
Sequence:
MAGRVKWVTDIEKSVLINNFEKRGWVQVTENEDWNFYWMSVQTIRNVFSVETGYRLSDDQIVNHFPNHYELTRKDLMVKNIKRYRKELEKEGSPLAEKDENGKYLYLDFVPVTYMLPADYNLFVEEFRKSPSSTWIMKPCGKAQGKGIFLINKLSQIKKWSRDSKTSSFVSQSTKEAYVISLYINNPLLIGGRKFDLRLYVLVSTYRPLRCYMYKLGFCRFCTVKYTPSTSELDNMFVHLTNVAIQKHGEDYNHIHGGKWTVNNLRLYLESTRGREVTSKLFDEIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDKLKPWLIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILYDEELAQGDGAERELRSRPGQPVGPRTGRSRDSGRNVLTTWK
The following text describes a protein:
Function:
GTPase-activating protein for the ADP ribosylation factor (ARF) family. Involved in retrograde vesicular transport from the Golgi to the endoplasmic reticulum.
Miscellaneous:
MISCELLANEOUS: Present with 1510 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus.
Sequence:
MSNDEGETFATEQTTQQVFQKLGSNMENRVCFDCGNKNPTWTSVPFGVMLCIQCSAVHRNMGVHITFVKSSTLDKWTINNLRRFKLGGNHKARDFFLKNNGKQLLNTANVDAKTKYTSPVAKKYKIHLDKKVQKDMELYPSELVLNGQDSSDSPLDTDSDASRSTSKENSVDDFFSNWQKPSSNSSSKLNVNTGSLAPKNNTTGSTPKTTVTKTRSSILTASRKKPVLNSQDKKKHSILSSSRKPTRLTAKKVDKSQAEDLFDQFKKEAQQEKEDEFTNSSSSTKIRQNDYDSQFMNNSKGNNNNSIDDINTQPDEFNDFLNDTSNSFDTTRKEQQDTLTPKFAKLGFGMTMNDANDLAKQQKESQKIAQGPRYTGRIAERYGTQKAISSDQLFGRGSFDEAANREAHDKLKTFDNATSISSSSYFGEDKEVDEFGNPINSSGSGAGNFDGRNSNNGFIDFNASADDELQMLRDVVEQGAEKLGSYLRDYLRK
The following text describes a protein:
Function:
Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.
Sequence:
MNESECIVDGVNLEVVLFGSHSKHFPILCSDDDMSLDSSEIVEYYEDEEQESYVLIFSPNQQHKNTPLFKAEWFTMYRPLLGSFIFEPPPYERRKKMEARIAGVDGYYKSLLSFIDKVVEEGFISPNVRQIILSVPTAIELVEKLEEYVPCHERVSSKLNWETEKQLGYPQPQQIVR
The following text describes a protein:
Function:
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity).
Subcellular Localization:
Cytoplasm. Postsynaptic density. Synapse. Note=Postsynaptic density of neuronal cells.
Domain:
The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.
Sequence:
MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFGSEQQLTQFAEKFQEVKEAARLAREKSQDGGELTSTALAMASHQVPPSPLVSTNGPEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNQRLAGALREANAAATQWRQQLEVQRAEAEHLRQRVAELEAQVAAEPVRAGEKEATSQSVEQLEARVQTKDQEIQTLKNQSTGPREAPDTAEREETQQQVQDLETRNAELEQQLRAMESNLEEARAERERARAEVGRAAQLLDVRLFELSELREGLARLAEAAP
The following text describes a protein:
Function:
Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRFRIYKRKVLILTFVVAACGFVLWSSNGRQRKNEALAPPLLDAEPVRGAGARAGDHPAISVGIRRGSNDSAAPLVAAAPQPEVDNLTLRYRSLVYQLNFDQTLRNVDKVSSWVPRELVLVVQVHNRAEYLKLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVDFCPVLQVFFPFSIQLYPNEFPGTDPRDCPRDLEKNAALKMGCINAEYPDSFGHYREAKFSQTKHHWWWKLHFVWERVKVLRDYAGLILFLEEDHYVAPDFYHVFKKMWNLKQQECPECDVLSLGTYTTVRSFRDVADKVDVKTWKSTEHNMGLALTRDAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPKFWKVLVPQVPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNSNKQYMFPETLTISEKLTAALSPPRKNGGWGDIRDHELCKSYRRLQ
The following text describes a protein:
Function:
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MAPGRSCCNYRVFLCFVAAATIAIFGLLGLLKPLSNDCKMTFMYPNYIPVPLPVDRKHNKYGVYLYHEGWKRVDHREHLSQLSGVPVLFIPGNGGSFKQVRSVAAESDRAYNVGPADGYYYEQSSLTPLEAGSDERDIAELLAGTKVDEQYPNHLDWFSVDLEGEKSAMDGWILEQHANYVVKAVHRILDIYKESMELRKQHNESRSEALPTNVILVGHSMGGFVARAVVVHPGLRKGAVETVLTLSSPHRSPPLAVQPSFGNFFSRVNNAWIRGYESAKESEAPLSKTVVVSITGGAHDYQVRSRMSSLDGIVPPTHGLTVATSGMVKIWMSMEHQSILWCNQMVVQVGHTLLQLIDRRTGQQYTSPHVRLAIFVSNFRSALPQTFNLLPHRNKLSPYTQPYRKVSEKAISAKDVGLDTNVVSKAQVQVSTKSGFQPMKSTQFACPQKIHWVGDMFDDIHIKQPIMNVLSMDGKRRWMDIEELGRKGRDKHAWFVLVTNLSPCVGMRVHLWPEKSRSGDMAASERVVEVTKKMVQLPSGPTPPQIEPGGPGEQASPSGVLQLSPSELSGFRYLTVSVAPTPTLVGSIPPTVTMAVAHFFDPDQGKTSLSTTWLLASLYKRQFLWLWEYHPMVWQVSVAVSLSTLPITLDVKIVSCGVKTEGLAKEHPEPEDILKLCKARCFPPVALVWDPPYGLDVYPNLTTQVIVVDSSPPTWGSTYGSEHSTILLLADPHCVYDIGVSVSLITSASRFLLVNGLQIVGLCIAVVLFALMRQARAWEVDNSVPSFLACMEANFMLPVPFLAVTLGPILVYFSIVDFGSERRPTLSSFLGVSLACYLFANGTLALLAYLCNAVLSLAHSAYTWYISRWPPRHDQWTKRVLKSCGTALLNIQVVRKLRTWPMTTLGIGISVLVLFGHPSLGLLVLLVVHTWRCFWSLVSLRQQLCPTLISKKEDSPLLPSNGNSLSDGFNAKPLLFSDGESHSEIFYHQQGLLILHLVVMIILVPSLVAWAQRLGLEWTTPALLDSTSSLAAILHGLYNINVDINISLVKVPRLYGPPAPDAGLSFIYLLAGSYCFWAGLALAPYRAFYALGLVGITIAGIRIRDSQARGRGRRHFHRH
The following text describes a protein:
Function:
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Plays a role in the regulation of lipid metabolism.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MQLGKELQDSAGTGTSAARTTGRRKNTAVIYVTFLILTLDLSMMFLQFSVTPYLAKKLGFDTLWFGYLQTTVGVAQLIGGPVFGRFGDLFGARAALTLVCSANVVFFVLLALANHPILLFVHKIPTIFMHIVPACQMVLTDLSEPEKRADVLSKTGLCFGISLILGSTLGGQLNARFGESFTASVGAAVSAFNLLLVLCFIPKFTKTEAPRSSNKTESQKQGVFNVREITRLMKYPRVMQIFLIKVIGGLPAGIFQVMFSIVSMDFFQLQPEEHSYLMAFFGIVQMVIQGAVIGRLANRFPEKTLLLLSIGVAALVGLVQTYMETVFQLCISITLMMFSLSVLNVITDSILTKSVPSSDSGTMLGLCASVQSLIRTIGPTAGGFLYVNYGLSSLGLLQLIVNGTVFVYLLSRRLRNSAKDD
The following text describes a protein:
Function:
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of pyranonigrins, a family of antioxidative compounds.
Subcellular Localization:
Nucleus.
Sequence:
MAKKAELRRSCTFCRTRKIACSGERICNACRSRSIECVYDLEIAKGRPRLNKTTSTRASISAGPAGPSPITLEDGEPGDGGHSITSAVNPSITPLTGVMAELEVMFRENFGEDPMAAPSNQFQDRVARFNRNLAAGRASQGPSTPAGSLTYPGFLALLMQDLAETVTGKFGDLGCHPFFGPGERFYRACMLQDTTKTMFDTACLPSPSTSTPSGGEADILADYNSHLITQHLEVWMSNHPLSIIISKSLLLRDLRSQTANRVLLAVMLADAHHFADNSAKGDRLLQWAVSQLSNIPAGQEDLTTAQITLLLGWFHVCRGHSRRALCYVGYAGRITTKLASQLHESPLTGQTHINGIDRGAVEAEMIHHMYWVMLALTVWSFIQMDMPLADLLPAQLLQVLPARTTPDSTLLQLDRATDNLSTLKPQLSSLQSVWLLSHVTVLSAHLYALYPQHLRSPPEPQPWQDLMLHRLNRLLRQGRSLTQICSDSRNALLDIIVVLQKESAHGRGEPTLLALYLAVSIHLLFPRDETGHHVHNSQTFVLSDTLFQQLIASIQDLKQLFPAISSVARHDSSQPASTGSAGLHFYLLALDALGRALMYVLTVWDRVTAVEQRVWQDRLRGLLDGGLAMHDLFEYDALLQDHRWRSVKKHLKTACKGIKGVLSGSRDQGSRSSSSSVSSLDLSFALPSRPTPAMGIPTSEEGRSEMMFPTMPSASGIPSSISSSISHTSREVGLSWPGDGQILPTQEQGPRESSHPAASDLSDFDLAPFVSLGSIDSMQNGDERSRIMQQFSPNPMSLPSFWHDPQFSPAHHLVGTMPPPSLISLADLGMGERGQKRSSEKLGGLSEGDTPGTSADGGTKRRMKGMSN
The following text describes a protein:
Function:
Transcriptional activator.
Subcellular Localization:
Nucleus.
Sequence:
MAQLPPKIPTMTTPNWPDFSSQKLPSIAATAAAAATAGPQQQNPSWMDEFLDFSATRRGTHRRSISDSIAFLEPPSSGVGNHHFDRFDDEQFMSMFNDDVHNNNHNHHHHHSINGNVGPTRSSSNTSTPSDHNSLSDDDNNKEAPPSDHDHHMDNNVANQNNAAGNNYNESDEVQSQCKTEPQDGPSANQNSGGSSGNRIHDPKRVKRILANRQSAQRSRVRKLQYISELERSVTSLQTEVSVLSPRVAFLDHQRLLLNVDNSAIKQRIAALAQDKIFKDAHQEALKREIERLRQVYHQQSLKKMENNVSDQSPADIKPSVEKEQLLNV
The following text describes a protein:
Function:
Catalyzes the terminal and only committed step in triacylglycerol (TAG) synthesis by using diacylglycerol (DAG) and fatty acyl-CoA as substrates. Required for storage lipid synthesis. Major DAG esterifying enzyme in stationary phase when TAG production is particularly active. Involved in lipid particle synthesis from the endoplasmic reticulum, promoting localized TAG production at discrete ER subdomains.
Subcellular Localization:
Lipid droplet. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to sites of lipid droplet biogenesis in the endoplasmic reticulum.
Sequence:
MQDSMDDSLREAEGRQDDSEVSSGTTLGSSTPEDSGVTAKLRKKYQMASALLRRELEELSVYDAKTAGVSGRSSGSGSGGLALLGGRFHVAPLRIPARRRLQTLVVAWHTSSFIYMTVLVLFLAANPLMWWFMVPYMVYYVWNRSPANGGVVRRYSPRLRSLALWRYYCEYYPISLHKSEDLAPTFVPDPRGAEPREWKLRLWLWPTRVELLNLTLQWTRARPQVATGPRYIFGYHPHGVGALGAFGAIATEGCNWSKVFAGIPACLCTLVNQFQIPIYRDYLLGLGCTSVARKNVLKVLEQNYSVCIVVGGAQEALLSRVGSTELVLNKRKGFIKLALETGNVNLVPIYAFGETDCFNVLDTGNESYLRKFQLWIKKTYGFTIPFFFARGVFNYDFGFLPFRNPINVVVGKPVYVDKRRTNPTMEEIDHYHDLYVQELRNVFDKNKHKFGYAGKELKIVE
The following text describes a protein:
Function:
Catalyzes the 3-beta-hydroxylation of 2S-flavanones to 2R,3R-dihydroflavonols which are intermediates in the biosynthesis of flavonols, anthocyanidins, catechins and proanthocyanidins in plants. Converts (2S)-eriodictyol to (+)-taxifolin and (2S)-naringenin to (+)-(2R/3R)-dihydrokaempferol in vitro.
Sequence:
MAAEAEQQHQLLSTAVHDTMPGKYVRPESQRPRLDLVVSDARIPVVDLASPDRAAVVSAVGDACRTHGFFQVVNHGIDAALIASVMEVGREFFRLPAEEKAKLYSDDPAKKIRLSTSFNVRKETVHNWRDYLRLHCYPLHQFVPDWPSNPPSFKEIIGTYCTEVRELGFRLYEAISESLGLEGGYMRETLGEQEQHMAVNYYPQCPEPELTYGLPAHTDPNALTILLMDDQVAGLQVLNDGKWIAVNPQPGALVINIGDQLQALSNGKYRSVWHRAVVNSDRERMSVASFLCPCNSVELGPAKKLITDDSPAVYRNYTYDEYYKKFWSRNLDQEHCLELFRT
The following text describes a protein:
Function:
Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MSWFADLAGKAEDLLNRVDQGAATALSRKENTSNIPYSKNTDYPELHQQNADLTHQTGSKATYISSAADNIRNQKATILAGTANVKAGSRTSGEASHPVENASVPRPSSQFVRRKKSEPDDELLFDFLNSSQKEPTGKVEIKKERGKTPVFQSSRTGVHSVNTGVPTVKTVEEDPGSQGHEAATNSVSGHEGQEDSSKENISPNTACADHNPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNLLSARTEALEALQNEKSRIMQDHSEGSSLQNQALQTLQERLHEADASLKREQESYKQMQSEFAARLNKMEVERLNLAEAVTLAERKYSDEKKRVDELQQQVKTLKSNVESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTANSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVSEAESARERLQDLQDQIAGQKASKQELEAELERQKQEFHYMEEDLYRTKNTLQSRIKDREDEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGVDSGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSIDQFSIRLGIFLRRYPIARVFVIIYMALLHLWVMIVLLTYTPEMHHDQPHGK