lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
Subcellular Localization:
Cytoplasm.
Sequence:
MVNITLPNTEERVNLLKSRINRLGDITVAGDVCAREIAMKTKNFTEDELCQLVREALHEAIVRTHVTRCPKGLQVTQVDLLAAVKIIQPRFGRQEETLQLLMPYEYLDRTAFDPNDLLSTGRPRWSCHLVEGKPKSGLTTVAAQMALKTDCPFIKYISSAELLGLSDSEKCQRIREVLEDAYVSRRSCVIIDDFERVIGYGALGKRYSKEFLQKLTVLLKKQPPNSHELIIICTSNRLDVLEELGLLSVFTSVHNVPNVSTPKELMVIVEASKRFEPEELRQIEIAMDGRNVSIGIKRLLDLIAWVNSLNPDRRAAKLLKKLGEAMGWVGNHSSPLVPQYI
The following text describes a protein:
Function:
Acts as a sensor for nitrate/nitrite and transduces signal of nitrate/nitrite availability to the NarL/NarP proteins. NarQ probably activates NarL and NarP by phosphorylation. NarQ probably negatively regulates the NarL protein by dephosphorylation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MIVKRPVSASLARAFFYIVLLSILSTGIALLTLASSLRDAEAINIAGSLRMQSYRLGYDLQSGSPQLNAHRQLFQQALHSPVLTNLNVWYVPEAVKTRYAHLNANWLEMNNRLSKGDLPWYQANINNYVNQIDLFVLALQHYAERKMLLVVAISLAGGIGIFTLVFFTLRRIRHQVVAPLNQLVTASQRIEHGQFDSPPLDTNLPNELGLLAKTFNQMSSELHKLYRSLEASVEEKTRDLHEAKRRLEVLYQCSQALNTSQIDVHCFRHILQIVRDNEAAEYLELNVGENWRISEGQPNPELPMQILPVTMQETVYGELHWQNSHVSSSEPLLNSVSSMLGRGLYFNQAQKHFQQLLLMEERATIARELHDSLAQVLSYLRIQLTLLKRSIPEDNATAQSIMADFSQALNDAYRQLRELLTTFRLTLQQADLPSALREMLDTLQNQTSAKLTLDCRLPTLALDAQMQVHLLQIIREAVLNAMKHANASEIAVSCVTAPDGNHTVYIRDNGIGIGEPKEPEGHYGLNIMRERAERLGGTLTFSQPSGGGTLVSISFRSAEGEESQLM
The following text describes a protein:
Function:
RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSGMTGQTPCLTSRWDRPAQPKQNMGLQQQKSTGNPALPASLSGVISTAGSNPVSHLPHTQESTPQGGVVMAAAMAAKINAMLMAKGKLLTPPPLLTKTPPSLPVPTTTEEMVVTEVDINDVPLNCRELLTKGKTQEEIRLFSGAVVSTKGHYMTEAERGNMGGQRPLYLHVLGKTQEQVNKAVARIKEIISEDVARASAASGGQVPVIPPLTLYPQPPRPVIPPPVPRMPNTNAVPSQGHRPAAPHTGSFVHTKIFVGLDQTLASFNIKEKVEGPAGSYLSHIQTETGARVFLRGKGSGYIEQASKRESFEPLYVYISHPNAAGLESAKKLTESLLETVRAEHARVMSAYATASTPQTYAAHGFPPNSNYPNQSSWYNYPANGYAGGYAAYPGASGYWSNANGPPSQSNLSTTPPSSQAMVQYPVCPRKPHPFLVQAPGSSETVEPEGSLTTPPDSGSTKQHSQEGAKDEQPSSCSPEGPAHLESTLPVPSAEEKVKDDRILMPPPPPSFLAPVGGPRKRPRDAAQEDAASLPTSSASLGAQEEVCVKKSKLKEDSSGLVPYGGDSSDDEEERTRCNSTRKDFPCGPVLSSEWAED
The following text describes a protein:
Function:
Probable thiol-disulfide oxidoreductase that may participate in various redox reactions.
Sequence:
MTVEKVDAALADFDAHFDRLFASPDAASDGKVKLLLFLADREPDSSLTWCPDCNVAEPVIYERLEAALQGKDAVLLRAYVGDKPTWRDPAHPWRVDPRFGLKGVPTLIRWEDGAAAARLGDDEAHLKDKFQVWCLSCSRTRMRRCTWQWCRQMQETMPISGILSNEEEMIFLI
The following text describes a protein:
Function:
Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MLPVLRSGLRRAVWRCGHGLLQRRIAAGAGWYARACASDDAASRSPLKQEMLNSTEYLHVQNILLQKNQQRMTKQKLLSEATGFYDRFKINTKWLLIRGNRPFSGEEISTLLSWLILSQVLWVILGTTTFVSLLLFLANTVLAKEMVGKFVGNSLNRYMDGVDVQFQDAMVPEWRKGQISFQKVRLRTTPGAQDAGLLTFDLMFSKLSLTLSVRKWLQGRGLINDVYVSGMKGDVSVGAAERKDAKLIDFFSNPNYELGEVEVCDSVIMCTDQEIGQKFRVSIYNMRMSQLRFRWSLLDLFNADVVSGALNHSLFSIHKRQHKLPLHEMEKDMAPWKRISRLRLNPISVKDLGLDKSNAFNWIEGGSVEMIADLMLPNIYPESAAAEDENKYVVMDLRITFKDLIASMNTVPPALSNGRELISFDELKPIIMFVNNRRGLFSSLRNLDNNKLWRPTVTIERQQSYPDTTVIPMRTFQWPEGEGSVQLNQEIIKYHENPSDNSNEIILRCRIAKHMNELQNTFLFKETDVYDKMALELYTDLMKMIEETEYKKKNDWVKLLGTTFASQLLIFGLGAMV
The following text describes a protein:
Function:
Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus, nucleolus.
Sequence:
MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRAWHKHGPGQTPDVKPVQNGSQLFIKELRSRTFPSAEDVVVRVPGSQLTLGYMEEHGFAEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVAKQKDCKMKLKEFVDYYYSTNRKRVLNLTSLEFSDTRMSSFVEPPDIVKKLSWVENCWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIKPASANISLYERWQSAANHSEMFFADQVDRCYKCTVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFRGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFKPSQLIKDLAKEIRLSENASKASRPEVTPAVPTDEVCFGDREKEEPPSPIEASPPRSFLEKVSKKKIPKTVKMPKPSKVPKSPKPPKPPKPPKPLKLKDGGKKKGKKCRGAASPTIPNLDLLEAHTKEALTKIEPPKKGKATKSVLSVPNKEAISSQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQKLEKCPLSGNRDPKFSFSFNRRLLSPKALKPQPSPGVFGAMQSFKEDKPQPVRDEYEYVSDDGELKIDEFPIRRKRTAPKRDLSFLLDGKEPLPTPVTKPKLESALYKSDDSSDEGSLHIDTDTKPARNAKVKKEGAGSAAGILDLLQASEEVGALEYNPNSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGAGQTKGSSLAAHGARKNGGGSKSAGKRLLKRAAKNSMDLDDYEEEQDHLDACFKDSDYVYPSLESDEDSPVFKSRSKRRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKSRKKKNTKRKLAPNTPSPSASTTSASTTSASTTSASTTSASTTSASTTSASTTSASTTPASTTPASTSTASSQASQEGSSPEPPPEAHSSSLADHEYTAAGAFAGAQAGRASQPMAPGVFLTQRRPSASSPNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL
The following text describes a protein:
Function:
Essential sperm cell-surface protein required for fertilization by acting as a ligand for bncr receptor on egg. The interaction of the complex izumo1:spaca6:tmemt81 with bncr is a necessary adhesion event between sperm and egg that is required for fertilization.
Miscellaneous:
MISCELLANEOUS: Izumo is the name of a Japanese shrine to marriage.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein. Note=Localizes initially to the acrosome membrane of the sperm head (both outer and inner acrosomal membranes). During the acrosome reaction, translocates to the plasma membrane.
Sequence:
MTLPILLGWFLTLCSSHIVRSCLQCDQVIRYVHEDFLSTVKGIRVRDQIELKKIIDHAYTNYRETSKLLSGVIDPTTLYRARTEYQSEFKRHWKEDRTNSLQWDLITIVEKGKRILQKHLEIFIAEGLCPNKCGLLYQRVMNCTSCQYGLFTCLSAKPPLDCGEHHLEADEGEEVVLDCFLSWHTLVVGQTEYHYSWHPGETNVLFDGEYEELVVTKESKIVLNQLSVSEEGSYRCLLKDQKGTALSRTFFQLEVKPFPSTSPRQVVTLPSLPLGYENTPYSLQKSSFLTVLILLTVLSITGSLIIIEYLRKSLKRQEEARGRDSRTAGDIELNTE
The following text describes a protein:
Function:
Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane.
Sequence:
MRLRQFLHMDLRWRTFIVTFSIACCTFFYMFQITSRKSRVIVEGKFTKTERWFHNNDAGESFDLQERQHIRNAMSDVEQIQAMVRHQLIKIYQESPKAQPLVIKMIKQFLPLKSALTAEIEELKELTKQEDGELFKKLRKTVARRIDLNQNPAKCSTAKKLYCNVQSACGFGCIIHHYTICLFISLGTGRVMMSNMSNLAYPNMDKIFLPLSRTCLTAEGNVDDYPEWESPNDEHPSSSDAPIVKVSIVYHRDRKTPFAPWTVPKDLIPSLERIHGNPMLWWIGQLQSYLMRPQKWLSDSIKEAKGEEFQHPIVGVHVRRSDKISEASYMANDAYMTAVSDWYDTYEMRHPNETVVRRIFLATDDILIGSQLKITYPKYRIVQIQKNAVVALAKRFSGSGLEGILQDVFLMAECDYFVGTMSSNVGRLVHELMQTRDYDTSNAAITIDHSFRYYGQFPERHLVLNDHHAENPCPPEFEPLPPNQFPKYVRERLQLENILKQGCEVELRKGDIIDAWPELNNNYMRGGVNIRSGRWGLYPKFKVKQIIEPAPYPVIENTSL
The following text describes a protein:
Function:
Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues.
Miscellaneous:
MISCELLANEOUS: Rv2613c is a unique Ap4A phosphorylase with a primary structure homologous to that of Ap4A hydrolase rather than typical Ap4A phosphorylases. Was identified as a high-confidence drug target.
Sequence:
MSDEDRTDRATEDHTIFDRGVGQRDQLQRLWTPYRMNYLAEAPVKRDPNSSASPAQPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITIIGGSKVIPQLLRDTRRLLATEWARQP
The following text describes a protein:
Function:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Subcellular Localization:
Nucleus.
Sequence:
MPGRVIVAPKGESIQFVQLLHPAEERLQWYGLRTESLLEVIQVGEECPSRSWFIGNEIVADGKVWVCSPCSLLPFVLPVLQELTWNRQNEPVRYVVLEDIKDSFAARGPAYALVLQILPNAFLRALNVACSKKESSNGMPETYQLSKKQVLTYLQQKIQVAVDNLPPSICSHLLQQLTPVEYGKNVPDDIVALAKRRCAIGFVCDGIIMPFASELTLNAEEHKQLDTYEKDIRDAKQRSQHDQFKDPSKRVLTSNNSTTKTKRSRTSESAGARKLKSVSTTNMMKISSFFKKKD
The following text describes a protein:
Function:
Flavocytochrome that catalyzes the reduction of fumarate to succinate. Is essential for fumarate respiration during anaerobic growth, acting as the terminal reductase (By similarity). Receives electrons from the membrane-bound tetraheme c-type cytochrome CymA (By similarity). In vitro, can use the artificial electron donor methyl viologen.
Subcellular Localization:
Periplasm.
Sequence:
ADNLAEFHVQNQECDSCHTPDGELSNDSLTYENTQCVSCHGTLEEVAETTKHEHYNAHASHFPGEVACTSCHSAHEKSMVYCDSCHSFDFNMPYAKKWQRDEPTIAELAKDKSERQAALASAPHDTVDVVVVGSGGAGFSAAISATDSGAKVILIEKEPVIGGNAKLAAGGMNAAWTDQQKAKKITDSPELMFEDTMKGGQNINDPALVKVLSSHSKDSVDWMTAMGADLTDVGMMGGASVNRAHRPTGGAGVGAHVVQVLYDNAVKRNIDLRMNTRGIEVLKDDKGTVKGILVKGMYKGYYWVKADAVILATGGFAKNNERVAKLDPSLKGFISTNQPGAVGDGLDVAENAGGALKDMQYIQAHPTLSVKGGVMVTEAVRGNGAILVNREGKRFVNEITTRDKASAAILAQTGKSAYLIFDDSVRKSLSKIDKYIGLGVAPTADSLVKLGKMEGIDGKALTETVARYNSLVSSGKDTDFERPNLPRALNEGNYYAIEVTPGVHHTMGGVMIDTKAEVMNAKKQVIPGLYGAGEVTGGVHGANRLGGNAISDIITFGRLAGEEAAKYSKKN
The following text describes a protein:
Function:
Probably forms vertices in the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered. Has been modeled to induce curvature upon insertion into an otherwise flat hexagonal molecular layer of CcmK subunits.
Subcellular Localization:
Carboxysome. Note=This cyanobacterium makes beta-type carboxysomes (Probable). Probably forms vertices in the polyhedral carboxysome (Probable).
Domain:
The tight homopentamer forms a pore with an opening of about 5 Angstroms in diameter which opens into a wider tunnel at the base of the truncated pyramid. The pore is positively charged.
Sequence:
MQLAKVLGTVVSTSKTPNLTGVKLLLVQFLDTKGQPLERYEVAGDVVGAGLNEWVLVARGSAARKERGNGDRPLDAMVVGIIDTVNVASGSLYNKRDDGR
The following text describes a protein:
Function:
Key component of the KaiABC oscillator complex, which constitutes the main circadian regulator in cyanobacteria. Complex composition changes during the circadian cycle to control KaiC phosphorylation. KaiA stimulates KaiC autophosphorylation, while KaiB sequesters KaiA, leading to KaiC autodephosphorylation. KaiA binding to the KaiC CII domain during the subjective day yields KaiA(2-4):KaiC(6) complexes which stimulate KaiC autophosphorylation. Phospho-Ser-431 KaiC accumulation triggers binding of KaiB during the subjective night to form the KaiB(6):KaiC(6) complex, leading to changes in the output regulators CikA and SasA. KaiB(6):KaiC(6) formation exposes a site for KaiA binding on KaiB that sequesters KaiA from KaiC's CII domain, making the KaiC(6):KaiB(6):KaiA(12) complex resulting in KaiC autodephosphorylation. Complete dephosphorylation of KaiC leads to dissociation of KaiA(2):KaiB(1), completing 1 cycle of the Kai oscillator (By similarity). Formation of the KaiB:KaiC complex is promoted by KaiA, helping switch KaiC from its autophosphorylation to autodephosphatase function; Binds oxidized quinones via the N-terminal PsR domain, allowing it to sense redox changes and possibly mediate clock input.
Domain:
The KaiA C-terminal domain mediates homodimerization and formation of a stable complex with KaiB and KaiC. The N-terminal pseudoreceiver domain (PsR, residues 1-146 in these experiments) is not necessary for most KaiA functions, while the linker region (residues 147-179) between the 2 domains is probably required at least for KaiA:KaiB interaction. Undergoes large conformational changes in the KaiABC complex which inactivates the second KaiA monomer, preventing it from activating the KaiC CII domain. The PsR domain binds oxidized quinones (By similarity).
Sequence:
MAQSTALTICGLVYSPAIGQELVRLHTSDIDELVYFSSEREFCNYLEARRNSIACLILEWGEGTPQIITYLHHSATLLPAILIFPAAPAPPPAGPHYHIAEVILTTDQLDQLNRQIEEAITGFVKLCPGCAVPPHVLFRLPALKESSNVDPQHRLSQKLKERLGYLGVYYKRDTAFFFRRMSPADKRKLLDELRSIYRTIVLEYFNTDAKVNERIDEFVSKAFFADISVSQVLEIHVELMDTFSKQLKLEGRSEDILLDYRLTLIDVIAHLCEMYRRSIPREV
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Subcellular Localization:
Cytoplasm.
Sequence:
MPQYQTWEEFSRAAEKLYLADPMKARVVLKYRHSDGNLCIKVTDDLVCLVYRTDQAQDVKKIEKFHSQLMRLMVAKESRSAAMETD
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSDALDLDQLQAQLELKRSALADSILSKLPGLSADTSSSSSSTALPKSAQHQQNSRPRQANLGVGATPKQQNADSSGSTRGPRSAADLRLKGALTAKRKRWQDQEPAVQNESDSDDQESSRVNVISANKKSKHENSQTTSLSNVGIPKPANKDPFAVNGIQAQKAAQNQPRIVVINGETIDLSKLSKTQRKKINKQLKAQHNQQQDDQAQDEVFKPATTTTLADALSTPESPLTSCSKATSQTPSSNNNQSSSPSGAALTPLQSQMLSKLSGSRFRTINEKLYTTASDEAVRMIDAAPTMFDEYHQGFREQVRSWPKNPLDRIVELFDPSLSIYKDKDKGKGNGKSKSKGTPSQPSGPSDRSKPRYAPGALVVDLGAGEGGLAKKLSPKAVKVLCYDLITTSDGWVRKQDTAAIGGLPLPGFFLDTDPLGLGATPEGVAQGVADVAVFCLSLMGTNWIHMLLEAKRVLRTGGELIIAEVSSRFGDGFEAFIRIVKLLGFGLEHKDASNTHFVLFEFVKLSQRDHLASLSALQDDSQIDPTHTSLDELAQHGKTLLKPCIYKRR
The following text describes a protein:
Function:
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MALALTCIVLLGGVAEGRHMVGPGFRPATIQSAPLEGTELCEACETLILEAQVVLTDPDNINAVVSLAESQLCLKLVDPQLVSKCRELVEEYIPALFQIMATEITPAKVCGAVCPVPPLFALAKHVLAGKEECQLCQYAATSLIAYLASNQTQVQIMTVAHTACLHVKKPELRAQCDTAVDEYVPQLLAVMQTITPAELCHILSFCPFELGGPVANKDECLMCHFLVLELRFKLEQPETQAKVIQFLEETCNRMPNLAAQCTESIAEYAPVIFQSLDAVMDPRLICKKLHVCPRAVSLQEAIGRV
The following text describes a protein:
Function:
Plays an essential role in the regulation of calcium transport at the sarcoplasmic reticulum (SR), which is secondarily required for regular muscle contraction.
Miscellaneous:
MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the SclB protein from a non-overlapping reading frame.
Subcellular Localization:
Sarcoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane, sarcolemma, T-tubule. Note=Colocalizes with SERCA at the sarcoplasmic reticulum and the diad, a structure composed of a single t-tubule paired with a terminal cisterna of the sarcoplasmic reticulum.
Sequence:
MSEARNLFTTFGILAILLFFLYLIYAVL
The following text describes a protein:
Function:
Thiamine-regulated, high affinity import carrier of pyridoxine, pyridoxal and pyridoxamine. Also imports, but does not export, amiloride and so confers sensitivity.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Note=During mitosis, also localizes to the septum.
Sequence:
MASKIASLFSPSETASKDQHENVAEDLELGTASSQSDGIHETNSEYDEKKREESPEVIDISNLISSDHPAHPQNWHWAKRWSIVFMFCLMQIYVIWTSNGFGSIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVDINAKYGWRWLYYINIIVGGFFLIVILIIPETLPIKVITRYENAKGRIVEGIPKNNLKEVLKKCKFVTTMGFRMMLTEPIILSMGLYNFYAYGISYFFLTAIWPVFYDTYKMSEMGASCTYLSGFVASTLLFLYQPIQDWIFRRDKAKNNGVARPEARFTSALFITLLFPAGMFLFAFTCHPPFPWMSPIVGNSMVTVANGHNWMCILNYLTDSYPLLSGSAVAAFTLPSFIGATVFAHVSQIMFNNMSVKWAVATMAFISISIPFIIYTFYFFGQRIRALSSLTGNKALKYLPLENN
The following text describes a protein:
Function:
(Microbial infection) Acts as a receptor for Epstein-Barr virus; Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner. Acts as a ligand for CD23 (FcepsilonRII), a low-affinity receptor for IgE, which is expressed on B-cells and other immune cells, and thus participates in the regulation of IgE production.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MGAAGLLGVFLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIHCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVVTLYMISKHRERNYYTNTSQKEAFHLETREVYSVDPYNPAS
The following text describes a protein:
Function:
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MKLAILIALASGAQAFAPTTTSSSNSALRMSEVPAEEVAEVAAPTVAPINGWVPDAAQPCYGLPGAISPLGFFDPLGFSNGELGTVKRLREAEIMHGRVSMAATLGYLIGESTPTITYGMDVHHTIANNQLTEVPGTVLFPFFLAINIAEAWRASAGWVEPGLGSLFELREKYYPGDIGFDPFGLKPKDAKEFANMQSKELSNGRLAMLAAAGMCVQEQINGQGILETLGF
The following text describes a protein:
Function:
Catalyzes the cleavage of thioester bonds from S-palmitoyl-CoA or S-palmitoyl-N-acetylcysteamine (unbranched structures) but does not have activity against palmitoylcysteine or palmitoylated proteins, branched structures or bulky head groups. Conversely, hydrolyzes both long and short chain fatty acyl-CoA substrate.
Subcellular Localization:
Lysosome.
Sequence:
MASIASSYPRDDVVAHIEGTRPLVIIHGLFEYSSSLSSLKHMITKAFPKIQIYIPDLFPGYFSVWTPLWKQVESFNEYLKPIFANTTKNGINLLCFSQGGIICRGILQTASNHTVRNFISLSGPLMGQFGGKNFKIIVTWVVNLSTSDTKKSIFYSIYGQKLISIANFWNDPHHQKLYLKYVTYLTALNNQTCHSSSQVFKSNFLKVKKVILIGGPDDGVITPWQSSQFGFYDKHLKIIYIKDFIGLRSIDKRNDLHLFTIGGVKHKNWHTNATVFNCCIRPFLK
The following text describes a protein:
Function:
Catalyzes the 2-beta-hydroxylation of several biologically active gibberellins, leading to the homeostatic regulation of their endogenous level. Catabolism of gibberellins (GAs) plays a central role in plant development. Converts GA9/GA20 to GA51/GA29 and GA4/GA1 to GA34/GA8.
Sequence:
MRYKKFIQTHILLFLTSLKKKKKSLLMILLDMVVSCQSILPNSSDIHRTCKPTSADQITNNKIPVIDMLDPQAKFLITKACQELGFFKVVNHGVPIETMTKLESDAVKFFNLPECEKDKVGPANPFGYGNKRIGSNGDVGWVEYLLFAINSGLVSEKSTNIPANSQFFWSAINEYVTAVRNLACVVLEKIADGLTIEPKNVLSKLLRDEKSDSCFRLNHYPPCTELEALSSGGRNFIGFGEHTDPQIISIIRSNNTTGLQISLRDGAWISVPPDQHFFFIIVGDSLQVMTNGRFRSVKHRVLANNIKSRLSMIYFGGPPLSENIAPLSSLMDEGEESLYKEFTWHEYKKSAYRTRLGADRLGLFEKKNIPYGQI
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MINLGYAFHVASVLGGNVTPFTDRIEDAVVQADEVGGDLLQFEGGLSVTATILSGVYRLAEAANKAPAVSKEQVLKFANYLLSRKNVQTVKGAAILYDVLRLLSVSSKHHVPVAVTVSGSSALSARSPTVVVRLTDVLGAPLAPVSLLLNSAVRLSDGQTVLERKPFAPSKEDKTLYVYNFMSGKPRRGFYKLSLNAVPVQTDARLLGNTNAEIQVKVLTEVEVVNLEVGTADRDQTAAPKMDAVAFKGKLAQTLEADHHQKLVMKFSLKDKSNADIMTAQQAFVHLQHQETKREIVFLAEPDSSLIYRFDLDLHLKAKEMGYLSGKYDLSLIIGDAVIANPLKWTLASLALSFPPNPSPPKDAVDIHAPRPEIKVPSSSCFFFFLASCSIWLSASLIPFPLALFRQWGRIGVNLSNFPFSLSTVLFHLGLAAIFGLFTCFWLRLTMFTTLKYLAALGAVTFISGHGMLTRLTQMKA
The following text describes a protein:
Function:
Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MESVVQQAFHEAGEFLAKIQLWSASIEDFIKIYSHPIKPYLPGLGRFLIVVIFYEDALRIGTQWEDQLCFLRKHRHFPWGLSHSFLVSNVVEQVNVDFLLGFRYLLKNLDWLEKKPKSCEDDFLIIDCPGQIELYTHFNVMHKIVQILTMEFDFRLCAVSH
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of the riboflavin precursor 5-amino-6-(5-phospho-D-ribitylamino)uracil and of flavin mononucleotide (FMN) in vitro. Also catalyzes the dephosphorylation of phosphorylated 5-6 carbon sugars and monophosphate nucleotides (NMP) in vitro.
Sequence:
MKCIAIDLDGTLLNKESVISAENREAIKRAVDAGILVTICTGRATFDVKALLDDLDIPIIAANGGTIHDTGYRLISRTLMDQEAGKAIADYLLSKNIYFEVYTDDHLLSPFDGEAKLHAELDILKSANPNEQTDDLWQGAMTQFKQFGIKPIPHIESVFDGGENIYKLLCFSFDMDKLKQAKEELKHHKKLAQTSSGKHIIEILPASSGKGRALTKLADIYGIETQDIYAIGDSPNDLSMFEVAGHRIAMENAIDELKEKSTFVTKSNDENGVAYFIDQLLSGQYA
The following text describes a protein:
Function:
Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides.
Sequence:
MTTLSCKVTSVEAITDTVYRVRIVPDAAFSFRAGQYLMVVMDERDKRPFSMASTPDEKGFIELHIGASEINLYAKAVMDRILKDHQIVVDIPHGEAWLRDDEERPMILIAGGTGFSYARSILLTALARNPNRDITIYWGGREEQHLYDLCELEALSLKHPGLQVVPVVEQPEAGWRGRTGTVLTAVLQDHGTLAEHDIYIAGRFEMAKIARDLFCSERNAREDRLFGDAFAFI