lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKENKALKSSVFVMLLIILGKVFALIRDSLIAAKFGATDITDIYNFSLGIVYLLTTISYGLTTTFIPIHTENLENGSKKESNKFVNNVLNTFSIGTIILTILMIIFAKYIIYIFAPGFQKDLIVFNTSIKITRIMLLSLIFISLQSVITGVLQSHKQFLEPAAMAMVSNIVYIIYLVFLASNYGMIGFAVAIVLGFFAQFIINIPKYKKMGYKYSTYINLEDNKTRQMFKLTMPVIISTSVIQLNSVINRAFATTIFGGAATILDNANKINTLAYEVFAIGIAMIVYPTLSELAAKNDKKQYKVELGRAINIILVIMVPAAVGIATLREPLINVIFKRGAFSENAASLTARALLLYTPAMIAYGVRDILNKAFYAIKDTKTPMINSFIGIIINVVINSLLIKYLGVSGLTLATSISAFVITIIMLLDLNKKLNGIDIKNIIISFLKVILSALIMGIIVAVINKFTLLSLGNETKGSAISILICMIIGGISYTLSIYLLKVKEIQDIVGPLLKILKLKK
The following text describes a protein:
Function:
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein. Membrane, coated pit.
Sequence:
MAERALDKVLGLSLDHYYHKAHLSVVKSLQSLVNKLLDVKSRQQEDKILCAEIELLKERMQSPNISSGEMKDFLVEIIFMTTHHYNVSFADIHAIKFTQQNSMKEKRIGYLAASCLLSEDHNLLVLLINTLQKDLNSTNFVENCMALSTVAMLINIETMPAVIQIVEKKINHTREAVRKRAVIALLKFHHLSAESANLASKLQEILFDSDFSVLTAVITAYLCLAKEDPAPLKPLIDRFVSIQRQLLAHKPPSDLNYRGISMPWLQIKLLRLLAYLGMDDFNCSQKIYPVIIDTLASIANPNCLIEYWIKGLSSIVQVNPLFAVEHQMTVVDCLDDPDETLRRKTLDLLCRMINPKNIVFITEKLIKYLQSSEDNYFKSDLVSRICQLAEKFAPDSFWYIKTMNSIFELGKDCVPVTMVDNLLRLIAEGTEDEQSDMELRMYAVHEYFKLLKRPKLSTLLIRAISWVLGEYAYLVDSIQMMNLADNMCILAENVLKQYPGCSCLLITAIMKLISRTNDVSDYTHNFLEEHSNSVNLDVQQRCQEALQLLITLDINDRSEILPVNASCEDIEVDPSLGFLDTFVSNALAYGSLPYRTLNQRKAIPDVKVRSSLKFDPYVNTSASSKETPVEDDGGRVIASHDYSKPEGTEFNRKEFNPQDVNAKKVEGQRPWTKEGYMIQAPLGGQDIEKKAKEENLSNIEEPPSQTILQNKPNYELEEKKRIASALFVGFDSDDIKSLAPAAKDERNRVNDQSSTTASEVTLSAGINSAEPYESPKPASDLLIGDNSTESNLINLSIENIKITEEQLNTNENSRYLEKLIDVEKNQLLDLENNPSPMSANPVADRSIQNPLDDLTDSTISIERELFPAELLSFPHGNLDVLSTPSFGKLRIALMKVWKEDAFIIVLAIANQADKQYNKISTVLKPSSGIQCAVNEKKMENPNFIDNLDIGESVCISARLMFDIYGLG
The following text describes a protein:
Function:
Member of gene cluster sufABCDSE that mediates iron-sulfur cluster assembly under oxidative stress and iron limitation conditions. Binds [2Fe-2S] and [4Fe-4S] clusters by mobilizing sulfur atoms provided by the SufS-SufE cysteine desulfurase system and then transfers the assembled Fe-S clusters to target proteins including ferredoxin and aconitase. Seems to act as a Fe-S cluster carrier rather than a scaffold, this role being performed by SufB and SufC.
Sequence:
MDMHSGTFNPQDFAWQGLTLTPAAAIHIRELVAKQPGMVGVRLGVKQTGCAGFGYVLDSVSEPDKDDLLFEHDGAKLFVPLQAMPFIDGTEVDFVREGLNQIFKFHNPKAQNECGCGESFGV
The following text describes a protein:
Function:
Involved in the activation of the NAD-dependent methanol dehydrogenase (MDH). MDH activation by Act involves hydrolytic removal of the nicotinamide mononucleotide (NMN) moiety of the NAD cofactor, changing its ping-pong type of reaction mechanism into a ternary complex reaction mechanism. It requires the presence of magnesium ions and is also able to use ADP-ribose.
Sequence:
MGKLFEEKTIKTEQIFSGRVVKLQVDDVELPNGQTSKREIVRHPGAVAVIAITNENKIVMVEQYRKPLEKSIVEIPAGKLEKGEDPRVTALRELEEETGYECEQMEWLISFATSPGFADEIIHLYVAKGLSKKENAAGLDEDEFVDLIELTLDEALQYIKEKRIYDSKTVIAVQYLQLQEALKHK
The following text describes a protein:
Function:
Transcription factor that binds DNA to G box 5'-CACGTG-3' and, to a lower extent, to E-box 5'-CANNTG-3' in vitro. Binds to chromatin DNA of the FT gene and promotes its expression, and thus triggers flowering in response to blue light.
Subcellular Localization:
Nucleus.
Sequence:
MNGAIGGDLLLNFPDMSVLERQRAHLKYLNPTFDSPLAGFFADSSMITGGEMDSYLSTAGLNLPMMYGETTVEGDSRLSISPETTLGTGNFKKRKFDTETKDCNEKKKKMTMNRDDLVEEGEEEKSKITEQNNGSTKSIKKMKHKAKKEENNFSNDSSKVTKELEKTDYIHVRARRGQATDSHSIAERVRREKISERMKFLQDLVPGCDKITGKAGMLDEIINYVQSLQRQIEFLSMKLAIVNPRPDFDMDDIFAKEVASTPMTVVPSPEMVLSGYSHEMVHSGYSSEMVNSGYLHVNPMQQVNTSSDPLSCFNNGEAPSMWDSHVQNLYGNLGV
The following text describes a protein:
Function:
Probable methyltransferase.
Sequence:
MSEDQIRHCGYCLKEIKGAEVKKCAGCLRRCYCSRDCQVADWGSKGQTHKLWCKENICEEDLDWEIRDSPGKGLGVFAKRMIPKHTKIMVDKGYRGVQETPSDFLNTLMPHPGSLQEKWDLNSFYTPEGGDNIGIRLARVNFDCRNNATNKFVPDLSTFILIAIRDIQQDEEISIQYYFYNDFSTSKEIRDARETIIKEKWEVNCDSTCICKNSEIKDKIQKAHELDELIPTLPLKTENDVKKSLKHVDDLIKMNQELSSGIMPLSRAYYDGFQIAITHKKTFPLHKKYIEKYLEAMEIVNSKHSQAYSEALQYLKYPNSHRNHY
The following text describes a protein:
Function:
Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Domain:
The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal.
Sequence:
MARPRHLRGLGMCITAVLASFIAGFTVGWFIKPLKETTTSAGYHQSIQQKLLSEMKAENIRSFLRSFTKLPHLAGTEQNLLLAKKIQTQWKKFGLDSANLVHYDVLLSYPNETNANYVSIVDEHGVEIFKTSYLEPPPDGYENVTNIIPPYNAFSASGMPEGELVYVNYARTEDFFKLEREMNINCTGKIVIARYGKIFRGNKVKNAMLAGAMGIILYSDPADYFAPDVQPYPKGWNLPGAAAQRGNVLNLNGAGDPLTPGYPAKEYTFRLPVEEAVGIPNIPVHPIGYNDAERLLRNLGGAAPPDKSWKGSLNVSYNIGPGFTGSEYSRNIRMHVNNINKITRIYNVIGTIRGSTEPDRYVILGGHRDSWVFGGIDPTTGTAVLQEIARSFGKLVNGGWRPRRTIIFASWDAEEFGLLGSTEWAEENAKLLQERSIAYINSDSAIEGNYTLRVDCTPLLNQLVYKVAREISSPDDGFESKSLYESWLEKDPSPENKECPRINKLGSGSDFEAYFQRLGIASGRARYTKNKKTDKYSSYPVYHTIYETFELVQNFYDPTFKKQLSVAQLRGALVYELADSVVIPFNIQDYAKALKNYAASIFNISKKHDQQLRNHAVSFDPLFSAVKNFSEAASDFHRRLTQVDLNNPIAVRIMNDQQMLLERAFIDPLGLPGRKFYRHIIFAPSSHNKYAGESFPGIYDAMFDIENKADPSLAWAEVKKHISIAAFTIQAAAGTLTNVL
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body.
Sequence:
MGKKGKGKGNKLANMSEEERARYLQMRADMEEETRRRKMQLISMYMKNKLKREDAFGRLNMAKINQEWRSILRQVKIQELRREIVDVESFFQEALKRKDQVIHRLIAHIESTEDMYANLQQSHMENITRIVDTHRDRIEFFRTIYEDDKQAVLSQWEQDSAAFKEMHAQKQQQLECVFYQLEENTDGGIRDNHERFLDRCEDLKSGMQLQLEQITSRGEARLEKLWQEYQGVLAGYCQHIEGFYSEYVDLKQRDEEAALQISQQTHEIEHLVDQLTNLRLVSEEFYIKQQGQLEQRQAIKQQLTERLRELRTCVEQEVARDHQLFKLMSVESYHALEFLQETVAKGETLAQLSAVCAKMETQRERMFQLPEISKEIIEIRDIEDQGNGSLTDPATDLLKDEVAVVPQMESFWRRVNNVAVDVACLKQQKRRLEAENSQLKTQLQDYLVNLNIANGSNSHVHSYLARRPKSMSVDRVSRLQLQPKLVKSAQPTGRRPAAPTPPTFHLHPGRSRAPAFEANLSNVVLSRTLARGKMNLARME
The following text describes a protein:
Function:
Transcription factor that modulates the white-opaque switch.
Subcellular Localization:
Nucleus.
Sequence:
MDQTYLDQQQLDANVNHQQLSQDTNSIPQQQLQQQQQPLQQLQQYQQQPLSNANFSGDNRFQQYQPRVTPSVSSSQQSIHNTTGYVTMHSGNYTPNQQYGVPNQYTVLQQQPPRQQSYEENINPLSYNSNYRTLSAPIPPLHIQHQLASKQNQDQNQSQNRYEQSSMTSIHTNDNSSSVNNSPNTMMIKQEHSTFQPQHSNEGSSAYHPVDQQNHQQQQQPQQQQQPQQQQQPQQQQQPQQPMTRSICTRCKKGFDQPIIYPKSSNSTNGNNSNGQNSSSIPPPEPRTFKLCDHCRKLQRQRSRRWQKKTKDREGVCRRCGSEIPLAERRFVLCPSCRENLRLRKASRAAQGRCVHCSGPLDASILSKENEGNNNGDEQNNKSNEDQNNESRRGSQEKPARGASHKVCQRCRENDKIRRANLEKMGNCNRCAKALDPNEYGRNKVCFNCRTKKKRSPPENVTNTDEVRTSPIQNQYGMNMSHQYIQPPPPPPPPLMTGHHQFQPQPHMMGHEQMNTFTTMSNSGVAGIQQPNNGMVVGDQQQQQQQHNGSMQLQPTYYQSYVQMPPPLQLQQQQQQQQQHYSLDGIPQQPHSAPTSSFPPPPPPPLQLNQHQGLQQYSHAQQQQQQQHQQQQPYHQEYPNN
The following text describes a protein:
Function:
Recruits the lipid transfer protein VPS13 to the prospore membrane during sporulation, thereby aiding prospore membrane formation.
Subcellular Localization:
Prospore membrane; Peripheral membrane protein.
Sequence:
MDSIVNVVEDDVKYAQRVTSFSSPQNANVKVFTIPRHSFTAFRLSYVSPTELSACSQVTLLGGIPKQWYADQNNQVWKLLTKISLRKVRKQSDMLRRYGYGTIYKKRVGKIPTALYLRKHFTWSYEDNTSIHNGHRLKEAEMEMKRTRSSPVQKSEYKLSLPRRCRSSSDQNFMRQELLKEKKSELSRNNSLPLIDTAQAVDIHPVLHEEDQENTNKRNKSLLSNLKRKDLGESKSISRKDYSHFDRIPSPSSARSVGETDFNYNREPSEDTLRYPDSIIEVTNRTSPAPNSILSRSGQFVNSNDLSDGFSTSNTINNVGLNANEKIFFNALQSMEKENLMLWKTSQKYGTYLDERRKSADAFQKRERGSCVDIGKLHSSHLPFINILPPWPTELTEEERIIHDRLASKHSHHIRKHVHNARNKTSCKIKDSVGTFLGMTNSLTNKATVKKRTGQILKKEKMLVMVKEAIQNKVPLPNFSENECFDTRVSERWKEYIVIARSTGRFDPPILLQFYRHRHIPEIEDISSIATKYHRNPLDFFLSRNCIVKFYSSLDKTISIQKPDKRLGGFIDESIEKKDELKHYSPIKIFILRCSSIRSSGRWYKFLLESLDRQLFTPAINLKIPLTEISIKINLNEIIFQKLIDLGKQEKDRLKICFLQRGYKIFQHPILRYFTVAILEKLKLAHYDYLIRKWDTENPVLGCALKRYDRLEWIPCDEDSLVTGIFAFCQSHLIQYRPIANRLRETKSLEGKCLKEPTPIEGFLIRLTDKYGSARTNFGKYSISTAYFFTCENLLFSMKAYRANPPLPIDSMIDDTSTEIEKEEIWKQWKKIPEVYEQQPYPLDTNDHIEWMNCQTTQSEYDSRDFYAFHCFHRRIDQILKTDNVIDLTEVKDIYQGTRTDYEADKIKYGVYKEASEIFWHRNYEIDDVSRSVINIETSNGLLLKLLATSATVAEEWVIKLKQMISYWKNKQREDTERLLKIRRSNAGLLMLNGEEETKIGENTLRWIVEHGRADEQTFNANGISLSRPLIQKGPLYQKPHKHSVFSKYYVVLISGFIVLFHCFHRSTTGFAKEVLEYAHYVTIPIDDCYLYSGTTTELDLLQRDRTFDEINYGSHALPRVYGDGWRSVEDESSRCFTLWFGTRRALSSNRLQKKGNEKQYTQDYGRQDNNIDPPSAPEADLNNSNVPSNTDKIHFTKKLGVSGKSMVFMARSRQERDLWVMSIYYELERLRRTASTSNSRNQTM
The following text describes a protein:
Function:
Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.
Sequence:
MKRGGRIDRARIIAEAAARISQELDAAAIMVSGDLSFEGIETGGIPVYYISMRPKSIIDHLVATGKEGKSPAKELSDQLNREASGNVDHLQHAAAIEYVLEGPKSGTIVGVVETRGSSSIIVHSLDENPLIKAMKECEERVRPEVMNAVLKIAFDIALTGREGKKIGAAFIVGDSEEVLKRSHQIILNPYEGHEEACRNVLDRKNWESIKEFAQLDGVFVIDETGIVHAAGRYLDVDGKNIEIEKGLGGRHVSAAAISRDTVAIAVTVSESGGVLRVYKDAKETICMESLQPATRYI
The following text describes a protein:
Function:
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
Sequence:
MKNLTPRQAQILKAIINEYIAYAIPVGSKLLTKKYFKNLSGGTLRNEMAALEKKGFLKKNHISSGRVPSQIGYQYYVKVLNVSNTTNDLKTRLRSVILQQHKTIDEVIELGVKFINEIINLPVVLTNFSSDEVLKKIDLIILDKSFALFLLVSASGKVFKKTISYANQRQFEDIVICVRIFNDRIIDTRFSEINNQLEVLKEIIRTKVHEYQYVIDEILFKLFDLDQIEANKKIYGIQYLAKQPEFANQEKLTKILNLLEDTSVWQQMAFINQTNQKTNIVFGDQLGFKEISVASTLINTTSEAKHQLAIVGPTRMDYQKIKALLTTLKEEIEKYDKKIHNQT
The following text describes a protein:
Function:
Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.
Subcellular Localization:
Nucleus.
Sequence:
MSYQVCFKKYVKMRQWPHVLSLRVYASYFLLYNNLPLSSAMVHDGVHLISIKTILTDQPCPNTIYYAKYQVQRKDNEDAASLLEDKEAYLRNQDCIVHAKNDLLFVYDFQAIPSIPEESSSFMLLNSGAFSRLALFQKDELALLLDLYINFLQGLKKTVLYWLCKEYNFVPIYGVLLPLKLHPSFDTQLWNIYGYPVVDLQLSVLSKGHIEFYLKPTRQTVYRLSEVDNLVKKLDTVIRLAPTGCLATLTSVHANASAQTVDALKHRYGFSLTTTSKWVGVTLESSALEFSWPLELCFLETSALRMNDDSLSSNLTDLNNLVLPSNVVNNKKELTEFANEEAEASDKRKEGFTEKEETADAVVTLVPSHSSSPVNYSINSAKSTPASIKVNEEILVADHNVSDDILMEEIDDVGITEADFDYFDLPNVEEKVEMIEPNFANTMTTLDNEEINTSISQSNTSPNLNTHENIPKQMEIQSDDRMVTEDLNPYNVEVDIPEISLNISDSKIPTSAYMPSYYSAVIFPSSISSIFQKYNYGGKYWCPSPSLSTEDLFESFSVAESVTSTDEDICSTNFIQQDFTMEYNHDFFSSSKTPTNISEQSNPDSNYDTLSLAHQVLMNESKSANFDFSFLKSLDLQPTITLGKNDLLNAILSQNLWFRSLPFWKSMTTSFMMSQDVLNFSSYMRKPIRDYLEKILLGESSAVFLSKSPENYLSSINNGHHALNDNPPSQVNFSETLVNFSQPPRVLLKYNEKKLSLDSSAPENWISLCLQPYGESKDFEVFLLSSKSPDVSSKAISFFYDVQLAYENCKLGKLNLSETSINERVMGFSTNINETDNYDDNETTQSDTATSYEQLASVCVNELSGKNVLFFYFLEDDSEKLLKACQHFICVKDSIKRLGDNKFEDKSLRICTIPNSIFDSPNSHTTNSNSFFTKVSLDIYNNDPLLMDGSLKRREPAFLLKKPLLSTLNYQLKDINPRSSALGEYALHVTYTTVEEHLLICNWNDSYGEFETERRYFLQDLEIEDALQQILEVTFTFLNSMHMDWIVIVMKIGEMSDAEYLFWDQAIIPENLQGNVSLTVGYCSAEHGPGSTSKVFSRIPYSASSTVIRNNSSHELSLVAFIREMAMPVPNDEFKKISTILARGYLALDEDESYLPLLSIHLLISRNHDPYLMLNLILKHYLSMIYLQFRTYVSFSSLPLHISTVLYQKQLLQFMASDITHPVTS
The following text describes a protein:
Function:
May be involved in the polymerization of mannuronate to alginate.
Subcellular Localization:
Cell outer membrane; Lipid-anchor; Periplasmic side.
Sequence:
MKMPILPPLPLASRHLLLASAIALAAGCAGLPDQRLAQEALERGDLATAQSNYQALAAMGYADAQVGLADMQVASGDSAQQAKAEKLYREAAQTSPRARARLGKWLAAKPGASDAEHREAERLLSQAFEQGEDSALVPLIVLYLQYPQSWPEIDPQQRIDQWRARGLPQADLAQIILYRTQGTYAQHLGEIEQVCQRWLRRMDVCWYELATVYQMQGNAEKQKVLLEQLRAAYKAGRVPGERVDSVAGVLADGELGQPDPQTAQALLEEIAPSYPAAWVSLAKLLYDYPDQGDLEKMLGYLKNAQDAAQPRAELLLGRLYYDGKWAPQDPRKAERHLLKAAASEPQANYYLGQIYRRGFLGKVYPQKAVDHLILAARAGQASADMALAQLWSQGRGIQPNRVNAYVFGQLAVQQQVPQASDLLGQIEAQLPPAERSQAQQLLKREQQSRGNNWQATVSLLQSQDSPINEEEPESL
The following text describes a protein:
Function:
Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.
Subcellular Localization:
Mitochondrion.
Sequence:
MAFRNVVRGTLLIGGGAVATVFGLSHLTDKRKASITSVEAAELIKSSTQNELPSREAQLLTLQKTKEFDVLVIGGGATGCGCALDAVSRGLKTALVERDDFSSGTSSRSTKLIHGGVRYLQKAIMNFDIEQYKLVKEALHERANLLEIAPHLSAPLPIMLPVYKWWQLPYYWVGIKAYDLVAGSQCLRSSYILSKSKALELFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYTEVVRLLRRTDPESGKERVCGARCRDVLTGQEFDVRAKCVINATGPFTDSVRRMDNQEVKNICQPSAGVHIVMPGYYSPDNMGLLDPATSDGRVIFFLPWEKMTIAGTTDTPTEVTHHPIPTEDDINFILTEVRNYLSSDVEVRRGDVLAAWSGIRPLVTNPNSKDTQSISRNHVVDVGESGLVTIAGGKWTTYRSMAEDTLDAAIKAHNLKAGPCRTVGLFLEGGKDWSPTLYIRLVQDYGLESEVAQHLAATYGDQAFEVAKLAKVTGKRWPIVGKRLVSEFPYIEAEIKYALREYACTAVDVISRRTRLGFLNVQAAEEALPRIVDIMAKELNWKEQKKKEELEAAKNFLYYEMGYKSRSEQLTDRSEINLSPSDVDRYTKRFHKFDKDKKGFITILDVQRVLENVNVQMDANNLHEILNEVDLNKNGQVELNEFLQLMSAIQKGFVSSSRLAILMKSAEENLDQRDPIPVHRSGGGV
The following text describes a protein:
Function:
A minor shell protein of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. The isolated BMC shell component protein ratio for J:A:B':B:K:T:U is approximately 15:10:7:6:1:1:2. Not required for structural integrity of BMCs nor to mitigate propionaldehyde toxicity, may selectively transport specific metabolites. May be involved in electron transport across the BMC shell (Probable). Can be engineered to alter permeability of the BMC shell; The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
Miscellaneous:
MISCELLANEOUS: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate. BMCs can constitute up to 10% of total cell protein.
Subcellular Localization:
Bacterial microcompartment.
Sequence:
MSQAIGILELTSIAKGMELGDAMLKSANVDLLVSKTICPGKFLLMLGGDIGAIQQAIETGTSQAGEMLVDSLVLANIHPSVLPAISGLNSVDKRQAVGIVETWSVAACISAADRAVKGSNVTLVRVHMAFGIGGKCYMVVAGDVSDVNNAVTVASESAGEKGLLVYRSVIPRPHEAMWRQMVEG
The following text describes a protein:
Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MSDRHLYGSDHSYLSSKPSCSSCRRQSSTSQKNECMTNPGSIVLTQRWTVCNFESLLKLSRPGSCLRSTVFKDDAVPDACWQLCLYPGGKREENANNVSLFLKMSATSPSKEVVLKAEYRFYFLDDNDEPKFSNVNVGEFHAKPPKGGHSWGLRNIPTQKVQNSIRQDKSLVISCHIELIPDASKVPCKRVPITPSIEMPFAQIPRAHVESELEMLASGDGTDMTIVAGPLDGEREQFRVHAYKLRAHSDVFQMMLSHTEMRENQEKRIEILDFSPTSVRAMVEFIYAGVIKSDIDVYQAVDVMQIAEKYQILALKMTCEQHLLDRLNVNNVLECITHAERYNTDVLYDACVDFAIHNRQHVMALTSWRNFISDEPVLASNLLEKMVKSNDNSSPPVKKPRV
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 5740 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MLKDLVREKLLTIMNTKAYTQFNPEQLLQLENEMKIYMKSGDSALTEGNYFFLMEMLFYVLVYRNQDVDAQVVYNTLRDRLGENSYKMVIMKATLLQINGNDKGAIEYLENLLNDDLEYETDFVTYVSIAKKLIAIKTTSKNLSQESVLKEVVALTDKFPLDAELWWYASEIYFEMGQFEKACYCLEQVLCITPFNYACFGRLSETLYYEALRSKKQTKTELLEKALKNALRSVELSELYLKGWALVNIISRELGRNKQNDLIKLSASKLKEISAKSNNKDKITAELILNKI
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLSSLSAWFVNPRRNPLARLHMKTVAYRLSNYGLRYDDLYDPYNDLDIKEALARLPREVVDARNQRLKRAMDLSMKHQYLPDDVKALQTPFRSYLADMLALVKKERAEREALGALPLYERTLP
The following text describes a protein:
Function:
Chaperone that specifically binds and folds some, but not all, nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity (By similarity). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i) alpha protein independently of G-protein coupled receptors. Required during gastrulation and sensory organ precursor (SOP) formation. Plays a role in positively regulating synapse number and neurotransmitter release (By similarity).
Subcellular Localization:
Cytoplasm, cell cortex. Presynapse. Cytoplasm. Note=Detected in both type Is boutons and Ib boutons in close proximity to synaptic active zones.
Sequence:
MDAEHLKRLEGREAEHIPDILNEFNKKHADLLVFDSFHSDNQWHELWLAIFGILDDAQLGHLHTQCLNTVRILTRDEFSLQTNYIEHEVSQLLRLARVEASSLKLPATPDELKQQEEGQLQLQEQPSLAQSDIIAEALKCLCNLVYQSADCRRQCLRQHCLDAILKRVASSMRHPCALEYYDMKLLFLLTALEPAARTRLQIDLNGLTYMTKWLDDKLAEPSCSEEQLNIICELLKVMFNVTSAPDKSPNEYEIQSLHLTGVLRELLLRFGKMATDKERSVVTHAINLLTNISSSCLIELTLKCSNAEEQPKKAVEGVAKAKPAKCCALCFEKRNVRCLTVLLNYLRQALAQQEAEASSHELLSPVLTVLVKCSRSDRVMRHYLRQEILPPLRDVSQRPEIGQELRNHLCRFLTLPAMILRDLAAELLFVLCKEDVGRMIKYTGYGNAAGLFAKRGILDCRRVEGADYSSDSEDSDTEEYKKHQQGINPVLGCVEPKSKHNPLDDMTEEQKESEALQLVNLIEQLRQGGIVKPALIDKDGKPQPLEHILQLQEELPQQQLEQKRKT
The following text describes a protein:
Function:
Acts probably as a dual specificity protein kinase. Regulates hydrogen peroxide (H(2)O(2)) homeostasis and improves salt tolerance by phosphorylating tyrosine residues of CATC thus activating its catalase activity. Promotes growth at the seedling stage and prevents grain yield loss under salt stress conditions.
Subcellular Localization:
Cell membrane; Lipid-anchor. Cell membrane; Single-pass membrane protein.
Sequence:
MAMLPRCGLLDCLRGGERETPAHDPRVSAEPSGKSGRARRLDWAEVESVTGGFSSRVIGQGGFSTVYLASLTSSRLGAVKVQRSSERLHRLFRHELDVLLSLRHPHVVRLLAYCDEREEGVLVFEYAPNGDLHERLHRSGQKRAALPWARRMAVAFQVAMALEYLHESQDPAVIHGDVKASNVLLDANMDVKLCDFGFAHAGFSAAVLPAAAARASARHVMGSPGYVDPLFLRSGVATKKSDVYSFGVLLLELVTGREAICADTGCRLAVTVAPVVSEGRVADVVDRRLGDAYDREEAVTVAALALQCINASSGLRPSMTDVVRVLQEKTSALISAVGPKPASKTVVS
The following text describes a protein:
Function:
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system. Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MRKRGEPGAPEHENFVRAPLDRECSIKHKLTIAGTKAHFPHDSDCDSNGMKRFGRRYGFWSRLRMFLLFIVGLYIAIPFLVKICPAIQTQLVFLNLVRFPYFIDLKRPEDQGLNHTCNFYLQPEEDVSIGVWHTIPAVLWKEAQGKHLEWYEEVLSTNYPVILYLHGNAGTRGGDHRVQLYKVLSSMGYHVISFDYRGWGDSVGSPSESGMTYDALHAFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPGALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITASGIKFANDDNVKYISCPLLILHAEDDPVIPFHLGKKLYNIAAPARSLRDFKVQFIPFHKDLGYRHKYIYRSPELRQILRDFLGNTEQQ
The following text describes a protein:
Function:
Activates transcription. The consensus DNA-binding site of this transcriptional regulator is 5'-WWGTGAN(5-7)ACACWW-3' in which W is A or T and N is G, A, T or C. Regulated genes include those encoding proteins involved in nutrient and energy supply, redox control and polyadenylation of mRNA. Also regulates genes involved in oxidative stress response such as genes encoding manganese superoxide dismutase and catalase, and genes encoding a protein involved in nucleotide excision repair of damaged DNA and putative proteins involved in redox control, protein degradation and transcriptional regulation.
Sequence:
MTQVRETVSFKAGDVILYPGVPGPRDRAYRVLEGLVRLEAVDEEGNALTLRLVRPGGFFGEEALFGQERIYFAEAATDVRLEPLPENPDPELLKDLAQHLSQGLAEAYRRIERLATQRLKNRMAAALLELSETPLAHEEEGKVVLKATHDELAAAVGSVRETVTKVIGELAREGYIRSGYGKIQLLDLKGLKELAESRGQGR
The following text describes a protein:
Function:
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKHNFSLRLRVFNLNCWDIPYLSKHRADRMKRLGDFLNLESFDLALLEEVWSEQDFQYLKQKLSLTYPDAHYFRSGIIGSGLCVFSRHPIQEIVQHVYTLNGYPYKFYHGDWFCGKAVGLLVLHLSGLVLNAYVTHLHAEYSRQKDIYFAHRVAQAWELAQFIHHTSKKANVVLLCGDLNMHPKDLGCCLLKEWTGLRDAFVETEDFKGSEDGCTMVPKNCYVSQQDLGPFPFGVRIDYVLYKAVSGFHICCKTLKTTTGCDPHNGTPFSDHEALMATLCVKHSPPQEDPCSAHGSAERSALISALREARTELGRGIAQARWWAALFGYVMILGLSLLVLLCVLAAGEEAREVAIMLWTPSVGLVLGAGAVYLFHKQEAKSLCRAQAEIQHVLTRTTETQDLGSEPHPTHCRQQEADRAEEK
The following text describes a protein:
Function:
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
Subcellular Localization:
Cytoplasm.
Sequence:
MIILKSERFGELNIDENEIIYFPLGIPGVPFDRFIIKDLIEPVKWLIAIDDTDVAMLIIQPFKYFPDYGFELSDEIVSVLDAKSEEELEIYVSLLKYNDGVAANLKSPFVINKNKKIGVQILLEDDRYSFKEPIKK