lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Negative regulator of responses to abscisic acid (ABA), including in early development.
Subcellular Localization:
Nucleus.
Domain:
The PWI domain binds nucleic acids with significant help from its N-terminal flanking basic region. It has an equal preference for binding to single- or double-stranded species, and it contributes to RBM25 role in modulation of alternative splicing.
Sequence:
MADESSSPATGDPNSQKPESTTPISIPNPNPNPSLTPPPPQQHSQPPVAPLVPPGPPYAPPAQIPSSLLPTNLPPPPPFRPGMQFTPVANFQNPSSGVPPPGSMPQYQPQPGMRPFQPMANGYPGIHGVAPPGAMPPHGLLRYPSPYPTMVRPGFIMRPPGTIGAVQLAPRPLIPGMPGLRPVMPPMVRPASLPFVTPAEKPQTTIYIGKIATVENDFMMSILEFCGHVKSCLRAEDPTTKKPKGFGFYEFESAEGILRAIRLLTQRTIDGQELLVNVNQATKEYLLKYVEKKIETAKKAKESQGTKENQAEGPESEQDKLESADNETGKDGESKIKENIDIANSAVLTDEEREADREAMEKIETAIEERLKSNPLPPPPPPPADGSGMEFAFKSKDGDSNTDVARSDAAANDVETSGEHNRPDTSSPDWSKRNDRRSRERGEKEQEMDRYEREAERERSRKEREQRRKLEDAERAYQTRLRQWERREREKEKERQYEKEKEKEKERKRKKEIRYEEEEEEDDDDSRRRWHRAALDERRRRQLREKEDDLADRLKEEEEVAEAKRSAEEQNLQQQQLDALRILSGQAAIGSETVQTSPIENDHKATLQTVGESANEHHAADFEENGSGNESMAIDNNSGSEAHAPSKKLGFGLVGSGKRTSVPSVFYEEDEDEARKAKKMKPLVPIDYSTEEQEAVAHGGSGNTPPHLALAAEFAKRISSTNPKEETIETEKQRSRRSHDKASHRDRERERERDRDRDRVRDRGDGHSGPTKDAKESGKAKIIDTKFLDAKQLIDTIPKTKEDLFSYEINWAMYDKHQVHERMRPWISKKIMEFLGEEEATLVDFIVSNTQQHVQASQMLELLQSILDEEAEMFVLKMWRMLIFEIKRVEAGVPVKSKA
The following text describes a protein:
Function:
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPALSGPQYLGEGLKLIMRPGLRLFVLIPLTLNLLVFALLIGFAMQQFSHWVDLLMPSLPDWLSFLQYIVWPLFVLLVLVIVFFTFTMVANIISAPFNGFLSEKVEVVVRGRDDFPPFSWAELLAMIPRTMGREMRKLAYFLPRALVLLVLSFVPGVNLIATPLWILFGIWMMAVQYIDYPADNHKLGWNEMLAWLRSKRWACMGFGGVTYLALLIPLVNLVMMPAAVAGATLFWVREEGERALVK
The following text describes a protein:
Function:
Probable carboxypeptidase.
Subcellular Localization:
Secreted.
Sequence:
MDITVRLKDIVDSDLSPLISITHTKTHTQKTDSSAMAAKLWSSSICVITCAIVITISAAKPHFESDKISSLPGQPNADFNQYSGYIAIDEHQQRSYFYYFVEAETDPASKPLVLWLNGGPGCSSIGAGAFGEHGPFQPSGNVLVKNNYSWNKVANMLYLESPAGVGFSYSANKSFYQSVDDVITARDNLIFLENWLKKFPQFKGREFYITGESYGGHYVPQLANLIIKSKSKLNLKGIAIGNPLLEFNTDFNSRAEFLWSHGLISDSTYNQFTFACNYSQIRRQAATGFLTPVCSGVIRQVSSEMSRFVDSYDVTLDVCLSSVELQSEVLNQLQEERKINVCVEDETIVYLNREDVRKALHARLIGVKSWSICSEILRYDMQNLEIPTIGILGSLVKSGIRVLVYSGDQDSVLPLTGTRTLVNGLAKDVGLNTTVGYHAWFEGKQVAGWTQVYNEYLSFATIRGASHEAPFSQPERSLVLFSSFVEGKPLPRANGITKQKDSLIRLF
The following text describes a protein:
Function:
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Sequence:
MDDLDKEQLAMLRKVFDSFDHNKKGSIPSSMVRTIFIVMGHRVDDRMLRAIIAEVDADGSGELEFSEFVTLAAQFLVEEDAEEMQNELKEAFRLYDKEGNGYITTSVLREILHELDDKLTPDDLDGIIAEIDEDGSGTIDFDEFMEMMTGE
The following text describes a protein:
Function:
Membrane-bound, subtilisin-like serine protease that processes the P-factor precursor and other precursor proteins. Essential for cell viability. Cleaves substrate on the C-terminal side of dibasic residues.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Sequence:
MHPALLCGPILAIFLQFLVSSCSPLENDDLFLVQVEPEVDPVVAAEAIGAKYVRPLLNLKYHHLIKLHKGSDDSVQSSIRKRGIDAGILELERQTPRWRYKRDASESDELLNEFSNHFGISDPLFYGQWHIFNSNNPGHDLNLREVWDAGYFGENVTVAFVDDGIDFKHPDLQAAYTSLGSWDFNDNIADPLPKLSDDQHGTRCAGEVAAAWNDVCGVGIAPRAKVAGLRILSAPITDAVESEALNYGFQTNHIYSCSWGPADDGRAMDAPNTATRRALMNGVLNGRNGLGSIFVFASGNGGHYHDNCNFDGYTNSIFSATIGAVDAEHKIPFYSEVCAAQLVSAYSSGSHLSILTTNPEGTCTRSHGGTSAAAPLASAVYALALSIRPDLSWRDIQHITVYSASPFDSPSQNAEWQKTPAGFQFSHHFGFGKLDASKFVEVAKDWQVVNPQTWLIAPEINVNKSFGSVNNETITEMVSEFTVTKDMIEKSNFKRLEHVTVRVCIPFNRRGALEILLESPSGIRSILASERPYDENSKGFLDWTFMTVQHWAEPPEGVWKLLVNDRSGGKHEGTFENWQLALWGESENPSNTAPLPYDTLELPKEMVLGIYSEPNSDLTNSSTLLSPTSTSFTSYTVSATATPTSTSHIPIPTVLPPTQPVLEPSYREIVAFITFFLLFAFIFVAVIWTWISAFWKAKAPPPLSQQEIA
The following text describes a protein:
Function:
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding; The box 1 motif is required for JAK interaction and/or activation.
Sequence:
MTSSHAMNITPLAQLALLFSTLLLPGTQALLAPTTPDAGSALNLTFDPWTRTLTWACDTAAGNVTVTSCTVTSREAGIHRRVSPFGCRCWFRRMMALHHGVTLDVNGTVGGAAAHWRLSFVNEGAAGSGAENLTCEIRAARFLSCAWREGPAAPADVRYSLRVLNSTGHDVARCMADPGDDVITQCIANDLSLLGSEAYLVVTGRSGAGPVRFLDDVVATKALERLGPPRDVTASCNSSHCTVSWAPPSTWASLTARDFQFEVQWQSAEPGSTPRKVLVVEETRLAFPSPAPHGGHKVKVRAGDTRMKHWGEWSPAHPLEAEDTRVPGALLYAVTACAVLLCALALGVTCRRFEVTRRLFPPIPGIRDKVSDDVRVNPETLRKDLLQP
The following text describes a protein:
Function:
Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAEASSTGLASCHLAGSKSGAPGASGCQCTRCGRKASFASGHHHEYPCGHAFCELCLLAPQEYTTSKCTDCEVRTTVTMNQGHYPVDGFIKEDSSVEALPPKMVNNCSSGLEKTVDQLIINLEHSSSIHRNVSSPSAVMSETEEIDEALKIAGCNSEQLSNAIKMLDSTQDQTRQETGSLREVVEKQFDTLIASLDSRKKSLCEELVRRTDDYLSKLVTVKSYIEEKKSDLDAAMKIAKELKSAPSLRTYCDLTQIIRTLKLNFESELSQVSSIIPRNPPRLNINCSEVICMFNSMGKIEFEDSTKCHPQENEVGQNVQKKFNSKKELCCDVYSSLEKKRVDTVVLADEAPVPPLQAETPDRHLEGENKQPQKEVLVVASPKTVAVLPQLGSSPDVIIEEIIEENLECCPELVFVSHVTHPCHFYVRKYSQIKDAAMLEKKMKQVCSKSLHLDPSDTLELGARIFVNSIKNRMWCRGIITEIIPTKTKNVRKPCSPTKFSVCEISLIQIFMVDFGNSEVLIITGVGDTHVGPEHVGEQHITLSDFCLLVRKSEPYSEELLKDIPHLAHLCSLKDIVPYNSSEGWEKEAKVEFLKMVNKKAVLMKVFGEEDDILIVDLQKPPTNKISSDMPVSLRDALVFMELARFRSQSLRSHGENNTALCYRPPALPEEMTEVSVMVCHINSPTDFYLQLMENLDFLSLLKTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAFIEPSKRSHWSKKAKEKFEEKTQDKFVTCSVIKILENGVLLVELFDSRAPGTSAVSINEQLVKEGLASYEAGYTLKDNSKKHLEVWDPSPEEIISSEINSLSPLSVNSLANESFQSLYNKELPVSICNVLSPEKIYVQWLLTENLLTSLEEKMVAAYEHSEWKPVKWECDMHCAVKIPAKSQWRRGQIIRMVTDTLVEVLLYDVGIELVVNIHCLRELQENLKTMGRLSLECSLVDIRPTGGSDKWTATACDCLSLYLTGAIATIILQENSTTWPLPVKIFCRDEKGERVDVSKYLIKKGLALRDRRVSKSSNSHSPEKSLEIPLEQGDSVVTKCFQINFDTNKKIADKVNEHKVPESKEKYSESRTNGFYKPPAVPNTSSFEAIVSCIGDDGTIFVVPKLSEFELIKMMDEIQSNLKCLGLLEPYFWKKGEPCAVRGSDTLWYRGKVMEVVGGTIRVQYLDHGFTEKIPQCHLYPILLYPDTPQFCIPCQLYQTLPVGNVWQPDAIELLQELLSKREVDIHIMELPDHPWGKLSVHLYFDGMSLSYFMAYHKYCIFEHTEEIFKEKPRGQNKKYEDENWKIRFEDLLLPEMEAPILPPYLSSLLPPPEELYAVQVKHIVSPDEVYICLDSVESCTQLNNHGDTDDSGVSWEPESESLEEALQRLNKNVETFPPLTDFSSEMPCLAEYADGLWYRAKIVSIKEFNPLSVLVLFVDYGSTEKLTINRLRQIPIQLMQYPAQAIKVLLAGFKPPLSDSGKTRIPYCPRWSMEALWTMIDCLQGKQLYASSVAQAPEQIVTLYEDEQYPVHMSLVEMGLADKDE
The following text describes a protein:
Function:
Catalyzes the interconversion of 2-phosphoglycerate (2-PGA) and 3-phosphoglycerate (3-PGA). Required for guard cell function (e.g. blue light-, abscisic acid- (ABA), and low CO(2)-regulated stomatal movements) and fertility (e.g. pollen grains production).
Subcellular Localization:
Cytoplasm.
Sequence:
MATSSAWKLDDHPKLPKGKTIAVIVLDGWGESAPDQYNCIHNAPTPAMDSLKHGAPDTWTLIKAHGTAVGLPSEDDMGNSEVGHNALGAGRIFAQGAKLCDQALASGKIFEGEGFKYVSESFETNTLHLVGLLSDGGVHSRLDQLQLLIKGSAERGAKRIRVHILTDGRDVLDGSSVGFVETLEADLVALRENGVDAQIASGGGRMYVTLDRYENDWEVVKRGWDAQVLGEAPHKFKNAVEAVKTLRKEPGANDQYLPPFVIVDESGKAVGPIVDGDAVVTFNFRADRMVMHAKALEYEDFDKFDRVRYPKIRYAGMLQYDGELKLPSRYLVSPPEIDRTSGEYLTHNGVSTFACSETVKFGHVTFFWNGNRSGYFNEKLEEYVEIPSDSGISFNVQPKMKALEIGEKARDAILSGKFDQVRVNIPNGDMVGHTGDIEATVVACEAADLAVKMIFDAIEQVKGIYVVTADHGNAEDMVKRDKSGKPALDKEGKLQILTSHTLKPVPIAIGGPGLAQGVRFRKDLETPGLANVAATVMNLHGFVAPSDYEPTLIEVVE
The following text describes a protein:
Function:
Required for replication of brome mosaic virus (BMV), a positive-strand RNA virus.
Miscellaneous:
MISCELLANEOUS: Present with 12500 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MHDKKSPMANSHYLKNLKQQFRNKNLIETTIHLVKCNDHDSLAFLARTYGVPPQLRHVVWPILLKYHPMCISPNITSNTISWDPITNDFILNDPFLKSKAPTDKQDKSDDENILPYDIESIILHDLKKYFHSRSNPAGSSSNANTTNIATPTPVSSSDASTISSMEVLSPSLDYEFQIIETLKNAIVKFLLKWSKIFKYESGLAWIALGLAEWYPIYPYETMSPFNETHSFYEVEDYVVLSGRKHALLSTNNGNNGNSNSSSNNTNNNNTNITSGMHNLSINTNTSLHNSPYISHTLSYLYKEYPLPFELRSKLPTKPIFSFSALFERLALVILHCPDTILAHKQLKNDSNASSSSKANSNFNTNYFPIISGGDLSFQTQVFFKVFSSILPELYQPLTEESSLQPSSSRNSWIYWWLKCSGAKALQRQDRGRVWDLLLGWRPKPNMDTINFFLNYNDKKMDHLYHDTPQCDNEQYWMKDWIALYNNDPFWFPDLDSMALGSKKFPYDYSVFKELILRNRYGGTQSKAQKDNTVPSPGSDSNDKSELKLPFSSIDPHMQLIFIFIAILQFNEFKLLEFEEAEISEFLNNVPLLTKFDDSSYRKLYENTESSITSLPSSPTTSTMASLQSSSNSSAHISNYHMLIEVGNDAKASHCFDDLLNMAGDIWRKWLWRELEESSL
The following text describes a protein:
Function:
Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN4A/Nav1.4, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Perikaryon.
Sequence:
MGLLPGMLLWIALVSSVWGGCVEVDSETEAVYGMTFKILCISCKRRSETVAETFTEWTFRQKGTEEFVKILRYENEMLQLEEDEPFEGRVVWNGSRGSKDLHRLGHLITNVTYNHSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGKKANRDMASIVSEIMMYVLIVVLTIWLVAEMVYCYKKIAAATEAAAQENASEYLAITSESKENCTGVQVAE
The following text describes a protein:
Function:
Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MKLEEVLMEGNKSKKAAQIKQGEQPHLACRIRLQNKSATQDRKNRVTTSRQCHKKDIAPGKNINCLPEAGQKNPDCMQSAKKHRCSLIKLGVQEKVKNISSSSDLKRGTLKKTWNFRSRTKLIQFEQKTCGNHVEGQRTKRRSLSLLEHRVQNINLSKYREKKGALSCCKSQLHSPENLRGDVEERRPSSITHISSGNHKEERELIAKSSRSRLVKSKKPEIKTKNSVAVTTSKMPDGVEAQEQNKPCFLKCASNGEDTEKFEGTTEEGIHMTVTQAFLKSNMCKNDELQSSVVSNRQHGKLTEIDKDLNIQNLLELSTCLPVPKSDKTENSDCINPCFGREVAVYRDAVSSPLKDVKCPQCLDIKVVAEKVENNTLAVCQDAKRTWLAKHCDLPSSIERFPIVRLLDCCYIKSLLNPAGAKSIQSCKVHSGSLHVASSQGKVLPSGRDMRQNDLSNSPNLLQTGRFLPEESILVGKEMCQNSNRSSRCQNGKPFGERKQCVDFERPSKKIKMQRNLEKLAIQKVLTNVNMHSECGLQMEDKLDTKTFGGKLNYNETTCLSSLEHRTDFLLEQPTQKPQNQLVSLSCNEKVSEAQAITCDSSDIEKSLVLRNQQNVPEIKDMEPQINIDKNKKYDVSSVNVLDSEKMVSSNSSIGCSIKAKRICKDRTRCKAKKNLQAYSCQRVVPVSGKNVWPRESCARTSVWIHKNRTCDLEITLRSTDLLLHSGQEELHMPLIDTTKTLADMAMDHKAELPVESCTSGPVFHVDKTFSAIENESRFSSVDKPNRCPPEAKTRKKLKVSLDSLAKDVKNKRSISKRNNSIGVQNSGFSNGKSKTKEQKTSITKQELLLQTVSRNLSDFKIPLLKNKNEYGKSDYCRSSARNTCCLLDILEDATISRNKTGAEQTSSDESYKFHFQSEHMNVSISKEHANQFDSNYPECLYKENNEHMETSNESELKTSTLDNNFHSCSTDFKEMLIRENKDESNSNNLAQVKVSHGDIIQAYDDDVLVIDVIQDDPDLFGDIGEQETAYTKDNCTKTNFNTNIFSEQRLKSEPESPQLLEYRYLKIGSRESPVQDYERLESIADLSAEVDEVKSESASEISSIEGVTVPAFEGVQLTVLDDVTRSCITDAKYKFPEKMLAVKEEKANIWNIAKIENTQDFEPVSHDHHLELPLPTVKAAEPQWHNKAVEPWMNDFEFSRKDSLLPTSYPNSQDSWKIDKNGMQMESILVPPPWLPVFTCGSYRRKTNLGLLHVPHRCCRYHFNTLKGCERANCKFHHVPPPGDEEFCSDVLKKYLSIGEVVLLQRAVQIFTDYCKRSIPRLYLDSQIFKDLLASLLQSCLLKELFLVVNTGIIIKILPSVQFLLKVFEQVASMKLKDTVPDLTDMSCKLFDAGLALEYEHICCITKFLNQLQVSNHEITTFVSRFQERHFKKASLCDFDSAVAEFQHCKEKGDWAKLGTLYVNVRRGCGDVNEKYSVSIANILTSVLKEKLRIPFCEFAAAVNADANHNEADKHLLGRIGISVMFSYYKKQQWSKAKKILDALHALQIPFTVLKGLLGYERLASRCSIINVAVEIFLKCECIDGAMWVLKESDWVINTLSWPCDRMDVLTRHNLLCTMASEYITKSQYGKAFEVLKNLPGFQNSCDTLDVSQYNILFNKLFGACLENKHLEISSAIVDFMFTKIIPVEFNLLRELITTLGRNCLWLKARTHYKSALGLGCYPPLEGNLYRKLLLIPSYMTEVEMLLAIEIFLVANASSIQSLGASSQLLQIVLKRCEANNVHKEDDYQSAISRLMKAACISTPKLSLKYLTVNIRKEEVYSLQYASVLSWLKENMKWAGKVWLF
The following text describes a protein:
Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.
Miscellaneous:
MISCELLANEOUS: IgD is not present in every species and this does not relate to phylogeny and evolution. IgD is present in primates, dog, mouse and rat whereas it is undetectable in rabbit, guinea pig, swine, cattle, sheep and Xenopus.
Subcellular Localization:
[Isoform 1]: Secreted; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.
Sequence:
APTKAPDVFPIISGCRHPKDNSPVVLACLITGYHPTSVTVTWYMGTQSQPQRTFPEIQRRDSYYMTSSQLSTPLQQWRQGEYKCVVQHTASKSKKEIFRWPESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPECPSHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGLLERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPAAQAPVKLSLNLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPRSTTFWAWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVSYLAMTPLIPQSKDENSDDYTTFDDVGSLWTTLSTFVALFILTLLYSGIVTFIKVK
The following text describes a protein:
Function:
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MIEDFSEHHVGEANTLQHHGYSRKLGNSVLTLPLRQGAKGHPQHWSPYTDNGGTIAAIAGSNYVVLGADTRLNGDFCIHTRSDTSKLFKLTDRIFLASSGMQADRLQLQQMLKYRIQWYQYNNGGKVPSTKAIAKLTSTMLYQRRFFPYYTFNMIVGIDEKGAGVCYSYDPVGSTEPFRYGTCGSASSFVEPLLDCLLTRQHMVTQAPADLTMEEALGMLKNAFTGAAERDIFTGDTVCFHIVTADGVGTEMFELRKD
The following text describes a protein:
Function:
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Sequence:
MPEPGKKPVSAFSKKPRSVEVAAGSPAVFEAETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVREVGPADQGSYAVIAGSSKVKFDLKVIEAEKAEPMLAPAPAPAEATGAPGEAPAPAAELGESAPSPKGSSSAALNGPTPGAPDDPIGLFVMRPQDGEVTMGGSITFSARVAGASLLKPPVVKWFKGKWVDLSSKVGQHLQLHDSYDRASKVYLFELHITDAQPAFAGGYRCEVSTKDKFDCSNFNLTVHEAVGTGDLDLLSAFRRTSLAGGGRRISDSHEDTGILDFSSLLKKRDSFRTPRDSKLEAPAEEDVWEILRQAPPSEYERIAFQYGVTDLRGMLKRLKGMRRDEKKSTAFQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCVVGGEKCSTELFVKEPPVLITRPLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVELTREETFKYRFKKDGRRHHLIINEATLEDAGHYALRTSGGQALAELIVQEKKLEVYQSIADLMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYSFVPEGFACNLSAKLHFMEVKIDFVPRQEPPKIHLDCPGRIPDTIVVVAGNKLRLDVPISGDPAPTVIWQKAITQGNKAPARPAPDAPEDTGDSDEWVFDKKLLCETEGRVRVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAAPKISNVGEDSCTVQWEPPAYDGGQPILGYILERKKKKSYRWMRLNFDLIQELSHEARRMIEGVVYEMRVYAVNAIGMSRPSPASQPFMPIGPPSEPTHLAVEDISDTTVSLKWRPPERVGAGGLDGYSVEYCPEGCSEWVAALQGLTEHTSILVKDLPTGARLLFRVRAHNMAGPGAPVTTTEPVTVQEILQRPRLQLPRHLRQTIQKKVREPVNLLIPFQGKPRPQVTWTKEGQPLAGEEVSIRNSPTDTILFIRAARRAHSGTYQVTVRIENMEDKATLVLQVVDKPSPPQDLRVTDAWGLNVALEWKPPQDVGNTELWGYTVQKADKKTMEWFTVLEHYRRTHCVVPELIIGNGYYFRVFSQNMVGSSDRAATTKEPIFIPRPGITYEPPNYKALDFSEAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTLEIRKPCPFDGGIYVCRATNLQGEARCECRLEVRVPQ
The following text describes a protein:
Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MSSRSSWSSTEQINRTISSRADDLPPQPRRLEVVSKQATRVTALSTKLEWKIEQFEKLMKLIKNGSNLISRMFSVPDAPTVCWELHVYPNGKRDEDVNNVSFFLRQVGLARGEEPIMTEFQIYALDANNQRVSVCRDTKDFTNQQGRGKFQVSRDKMLGALRSDGTLFLICEVEYFPPGSKISVEPVVDEDVSTEEQEEMPEVIVRANNRSMWEDELFTDCVIHVGNKHIKAHRCILGQNSPVFKSMFSSPNMIEAQKGEIHIEDAKYDSVRAMVEFMYTGATESLESQGNIDEILAIADKYEVLMLKDQCERLIAQTINLKNVTQIAMFSDTYTADYLKSAVIRFLTTHHRVVIKTQDWISLKKSRHELANELLEAVLSTDQDDDDVTSNIPISVSPPPARKRLRRSAK
The following text describes a protein:
Function:
Member of the two-component regulatory system HptS/HptR that regulates genes involved in hexose phosphate transport system in response to changes in extracellular phosphate sources. May act as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of HptS. In turn, HptS antagonizes CcpA-dependent transcription of a subset of CcpA-regulated genes involved in antibiotic susceptibility.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTAYKPYRHQLRRSLFASTIFPVFLVIIIGLVSFYAIYIWIEHRTIHQHVDESQSSLHHTEKQIQTFITQHNNSFQELDLTNHHDVTATKRELLKLIHQQPATLYYELSGPNQFITNNYEHLNTKNMYLFSTHQLKFKNSTYMLKIYMANTPRLSEIKKDNRQFALIVDQYDNILYANDDRFTIGEKYRPQQFGFMNESVKLNHADHRLIIYKDIHENIEDGITLLIVMAVVLVLLVIFGFISADNMAKRQTKDIETIIQKIYYAKNRHLGTYTPLKNNSELEEINNYIYDLFESNEQLIHSIEHTERRLRDIQLKEIERQFQPHFLFNTMQTIQYLITLSPKLAQTVVQQLSQMLRYSLRTNSHTVELNEELNYIEQYVAIQNIRFDDMIKLHIESSEEARHQTIGKMMLQPLIENAIKHGRDTESLDITIRLTLARQNLHVLVCDNGIGMSSSRLQYVRQSLNNDVFDTKHLGLNHLHNKAMIQYGSHARLHIFSKRNQGTLICYKIPLSRGNVDV
The following text describes a protein:
Function:
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
Subcellular Localization:
Cytoplasm.
Sequence:
MADFNQILTPGDVDAGIINVVNEIPEGSCHKIEWNRKVAAFQLDRVEPAIFAKPTNYGFIPQTLDEDGDELDVLLITRQPLATGVFLEAKVIGVMKFVDDGEVDDKIVCVPADDRDTGNAYNSLADLPANLIKQIEFHFNNYKALKKPGSTKVTHWGDVEEAKEVIRESIKRWNER
The following text describes a protein:
Function:
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Subcellular Localization:
Secreted.
Sequence:
MGSRRLWLFPVLQILVSSAQLCEIPPGNGHRVASLSAELLSLAHDATRAPDPSLYLGLRLSERHSLEKERLYLERLQGVYQPNDSNDQVAPRYQEQPGTGRLALYLLALRGACHDMDTPEAHRLVTQLKLHLHKEKAEIGPESLGRPLSNYYQYGLGLLALCVHGKMVDGHVIHKLLHAEEHGRLGIHGKLSVDTEAMAGLAFACLQRAAFYPPELRAKLRQSVERVKGKILEGQTPAGAFGNIYSSPLAAQFLLAVGQSRKEPECPKGMASLLRHLEQGDSPDVLFKSQLLPVLNGKSYLDIASVECHAETGKEGRRAGAMVPKPPATHLFRNDRWLFSILVDLLLCRRPGPWHPLTHIATAHPAKQTDSRPADCEAPAAQAAPLPPGADGGPGLLSAGCAEGGFQARTGATHVSSPWQSSRSCQSQNPLGSSVLGLGFFAFHHLATPRLCFALLCPGLRPRRPSRARF
The following text describes a protein:
Function:
Negative regulator of the multidrug operon emrAB.
Sequence:
MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLSRLDQMEQDGVVLEAMS
The following text describes a protein:
Function:
Glycosyltransferase that transfers an L-rhamnose moiety from dTDP-L-rhamnose to the elloramycin aglycone 8-demethyl-tetracenomycin C (8DMTC) in elloramycin biosynthesis, an antitumor polyketide. Possesses donor substrate flexibility: able to transfer at least 11 different sugars to 8DMTC, such as NDP-D-glucose, as well as NDP-L-digitoxose, including both L- and D-isomeric forms of some sugars.
Sequence:
MRVLAVATPALGHLFPAVPLLWALRARGDEVLVVTGGDALRVAEAGLPVVDALPGETLTTLFGAYQETDPAFFVALRRSPMTTLRDLAPVLAYLAGRLLEPARRAAERWRPDAILATHGQAAGAVVAAEHGIPLVEHGFGFVRSDGAQEAVRQLLAERLGPAGSEPPPERYFLDIAVPSMTSAIEGMSLRAVPYNGGAVLPLSGASVGGRPPRPRVLVTAGTQLLHTHGAGALAWLPEVAAGHEAEFLLAAGGADLRDLGRLPPHVRVLDWTPLATVLPTCSAVVHHGGSGTTLAALAAGVPQLVSPALADNHINARAVADRGAGLETAVPDATTLTALLREPAFAKAAREVADELRSLPAPADVAARLHTAFGLPTTQGDA
The following text describes a protein:
Function:
Transcription factor that could be a key player in early mesoderm differentiation and may be required for subsequent cell fate specifications within the somatic and visceral/heart mesodermal layers. Essential for myoblast fusion and consequently muscle formation in adults. During embryonic and pupal development, binds to the enhancer of the myoblast fusion gene sing and activates its transcription.
Subcellular Localization:
Nucleus.
Sequence:
MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRVLLKYTEYNEPHESLTNKNIIEKENKNGVMSPDSPEAETDYTLTPRTEAKYNKIDEEFQNMMQRNQMAIGGAGAPRQLPNSSYTLPVSVPVPGSYGDNLLQASPQMSHTNISPRPSSSETDSGGMSLIIYPSGSMLEMSNGYPHSHSPLVGSPSPGPSPGIAHHLSIKQQSPGSQNGRASNLRVVIPPTIAPIPPNMSAPDDVGYADQRQSQTSLNTPVVTLQTPIPALTSYSFGAQDFSSSGVMNSADIMSLNTWHQGLVPHSSLSHLAVSNSTPPPATSPVSIKVKAEPQSPPRDLSASGHQQNSNGSTGSGGSSSSTSSNASGGAGGGGAVSAANVITHLNNVSVLAGGPSGQGGGGGGGGSNGNVEQATNLSVLSHAQQHHLGMPNSRPSSTGHITPTPGHDKYEGYPYRALMGHNPRWNLNFAGAPSSDQDVRLAAVAVQQQQQQPHQQQQLGDYDAPNHKRPRISGGWGT
The following text describes a protein:
Function:
Plays a role in targeting PPP1CA to the nucleolus.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MASISSQLEELYMNTSRKDMNDTLTDILLAACVTPALMPERLLMEHILLVSVLHYSVGLEVGAHFLETVVRQFDRIYSELDGTDKECDNLVSIIAHLYNFHVVHAVLVFDILKKLVTSFSSKDIELLLLVLKTVGFALRKDDPIALKELISEAQRKASAEGEQFQDQTRIRFMLETMMALKNNDMRKIPGYDPEPVEKLRKLQRTLIHSSAGSSDMKLRVSLDNLLEAERVGRWWIVGSSWSGAPMIDDQGNKTTTPSTKGEQYSAKMLELARKQRMNTDVRRNIFCVLMSSEDFLDAYEKLLRLGLKDQQEREIVHVLMDCCLQEKMFNRFYAVLAEKLCSHDRRFQMTFQFSLWDKFRDLANLSNRSFSNLVQLVTHLLHRKSLSLSILKAIEFGELDKPKVKFLKQILSKLLKETEPEDLVNIFGRISGIPKLGMLREGLKLFISHFLLRTVNTQEPPEQAKVLKDRAEVATKAMEARDAKIKL