lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Active thioredoxin with a redox potential of about -250 mV.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDLTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTIFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRFLNEICSACVIHCPVGLFLKSKLIFQCFFCIMLNQQFQCRKIAKKISLCLTAISWFGPCMDRVTG
The following text describes a protein:
Function:
Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. May prevent formation of excessive Holliday junctions or assist in their resolution.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MNASNNISKFPDLDNSSKLIDHILDSDDSEELDELPDISSLVPSARAQSRKQYLKNDSSNSSTYRWNIDLLSSTATIDDSVAKRRKLAVQNLLQYDSTQTFQTGDEIDELIGKSVGSNVLNVLRSNPIYDDDLRYEYCSNSKARVPDWNTLKAECLKDNDLEFNEGIIPTTFGDLLSAKLVPLDIALSICSLQFFRSLGDTTCSEWIANLEKIFYSYKSSSNNLNQIVRFIFETTADMIGIDLAKRQVPIQLERTSASENLKSNLKIKVINFLKCCGTLYRFSDDTVRFEMIQDACRILIDNQVGSFCKWQFSQFMELPISLNPDFLISNIHKVSESPRVWVTILSSLSRSCQKFRKKIAFTLFVGKQSKNDDSDFSSLCQRLDEISASCNNDYTTLLYQIRTFGYAVDEKHFKTNERLECLLEKLRKIDLTISGSTDHLLLSRCEVKDCIHRLFMVLYYLNTNSAPELERIIESDLPNNNKQKDRYFKDKTSNLSMKENKSFSAKKVKKGKKKNKRQAYKR
The following text describes a protein:
Function:
Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system.
Subcellular Localization:
Presynaptic cell membrane; Single-pass type I membrane protein. Note=Specifically present within the presynaptic compartment of synapses.
Sequence:
MNMGSVAGAVLKMLLLLSTQNWNRVEAGNSYDCDEPLVSALPQASFSSSSELSSSHGPGFARLNRRDGAGGWSPLVSNKYQWLQIDLGERMEVTSVATQGGYGSSNWVTSYLLMFSDSGRNWKQYRQEDSIWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGCAYRSVVIDLDGKSSLLYRFDQNSLSPIRDIISLKFKTMESDGILLHRAGPAGDHITLELRRGKLFLLINSGDARLTSSSTLINLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRRHFHAQGEFNYLDLDYEISFGGISAPAKSVSLPYKHFHGCLENLFYNGVDVIGLVKEHSPQIITMGNASFSCSQPQSMPLTFLSPRSYLVLPASTKEEAISASFQFRTWNKAGLLLFSELQLVSGSLLLLLSDGKLKLTLYQPGKSPSDITAGAGLGDGQWHSVSLSAKRNHLSVVVDGHISPASPWLGPEQVNSGGVFYFGGCPDKGFGSKCKSPLGGFQGCMRLISINNKMVDLIAVQQGALGNFSDLQIDSCGISDRCLPNSCEHGGECSQSWSTFHCNCTNTGYTGATCHSSVYEQSCEAYKHQGNASGFYYIDSDGSGPLQPFLLYCNMTETAWTVMQHNGSDLMRVRNTHSENAHTGVFEYTASMEQLQAAINRAEHCQQELVYYCKKSRLVNQQDGSPRSWWVGRTNETQTYWGGSLPVHQKCTCGLEGNCIDAQYHCNCDADLNEWTNDTGFLSYKEHLPVTKIVITDTGRPHSEAAYKLGPLLCRGDRPFWNAASFNTEASYLHFPTFHGELSADVSFFFKTTALSGVFLENLGITDFIRIELRSPTTVTFSFDVGNGPFELSVHSPTHFNDNQWHHVRVERNMKEASLRVDELPPKIQAAPTDGHVLLQLNSQLFVGGTATRQRGFLGCIRSLQLNGMALDLEERATVTPGVQPGCRGHCGSYGKLCRHGGKCREKPSGFFCDCSSSAYAGPFCSKEISAYFGSGSSVIYNFQENYSLSKNSSFHAASFHGDMKLSREMIKFSFRTTRAPSLLLHMSSFYKEYLSIIIAKNGSLQIRYKLNKYHEPDVISFDLKSMADGQLHHIKINREEGMVFVEIDENTRRQTYLSSGTEFSAVKSLVLGRMLEYSDVDQETALAAAHGFTGCLSAVQFSHIAPLKAALQPGPPAPVTVTGHVTESSCVAPSGTDATSRERTHSFADHSGTMDDREPLTHAIKSDSAVIGGLIAVVIFILLCVSAIAVRIYQQKRLYKRNEAKRSENVDSAEAVLKSELHIQNAVGENQKEYFF
The following text describes a protein:
Function:
ATP-dependent ligase that catalyzes 2 steps in the biosynthesis of the side chain of the aminoglycoside antibiotics in the biosynthetic pathway of butirosin. Mediates the addition of one molecule of L-glutamate to a dedicated acyl-carrier protein. Following decarboxylation of the product by BtrK, adds a second L-glutamate molecule.
Sequence:
MKFTHPLDYYRLNGKQILWYMNIGEDQDSQASNYFPSVKDPQSEKIVVQQEQQLLFLARPQDTVFFHTMPEQAFLDYWKERRLSLPSIICCDKLSQVPDLERYTIIPFIVSDQLLELKRRYPHMDIIAPDLAVCREINHKFNTRRLMERNGFNVTTGYFCSDIESLEHAYEQLISAGFSKCVLKVPYGSSGKGLKVIDNERNFRFLLNYIQNRQTNVDLLLEGWHPHRLSLTSQLFITEYEVHLLAVTEQIIDPNGVYKGTNFTPALSQSEAADYREEILRAGELIRQMGYRGVLGIDSILDTNGELIPVIEINARLTQVTYILPLVIEQKKRYEFVESRVLVFNSRADLDFEDYENDLSEVTRDLPVRIDLYNFCKASGAFKNTYKLFVLVSAHNSEQLIKARSLLDELNTKMTTAVH
The following text describes a protein:
Function:
Regulates vegetative and gynoecium development. In concert with HUA2, antagonizes FLK by positively regulating FLC probably at transcriptional and post-transcriptional levels, and thus acts as a negative regulator of flowering.
Subcellular Localization:
Nucleus.
Sequence:
MAAVADSVENNGSINLPENENLIPAGFSAAALLDENSGAFPELNQPDSLAAAETTFPDTNDSAEERWPGWPGDCVFRMIVPVTKVGAIIGRKGDFIKKMCEETRARIKVLDGPVNTPDRIVLISGKEEPEAYMSPAMDAVLRVFRRVSGLPDNDDDDVQNAGSVFSSVRLLVASTQAINLIGKQGSLIKSIVENSGASVRILSEEETPFYAAQDERIVDLQGEALKILKALEAIVGHLRRFLVDHTVVPLFEKQYLARVSQTRQEEPLAESKSSLHTISSNLMEPDFSLLARREPLFLERDSRVDSRVQPSGVSIYSQDPVLSARHSPGLARVSSAFVTQVSQTMQIPFSYAEDIIGVEGANIAYIRRRSGATITIKESPHPDQITVEIKGTTSQVQTAEQLIQEFIINHKEPVSVSGGYARIDSGYVPAYPPQLSNRQEPLPSTYMGTEPVQYRPTAYSQLGGPSTYTPTLTGQTYGSEYRPASDVGGYSSYNL
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MDSTARRSGGLFEGLYRVIMRRNSVYVTFIIAGAFVGERVVDYGVHKLWEYNNVGKRFEDIPVLGTRQSEE
The following text describes a protein:
Function:
Guanine nucleotide exchange factor. May be involved in cytoskeletal organization.
Subcellular Localization:
Cytoplasm. Cell membrane. Note=Associated with membranes through the PH domain.
Domain:
The PH domain mediates binding to membranes.
Sequence:
MYRRNGLPASVSITSRNTQDSSSSESLDGRSLDSAKSFDAVVFDMLKVTPEEFASQITLMDAPVFKAIQPEELASCGWNKKEKHSLSPNVVAFTRRFNQVSFWAVREILTAQTLKIRAEILGHFIKIAKKLLELNNLHSLVSVVSALQSAPIFRLSKTWALISRKDKATFEKLDFLTSKEENYNRMREYTRSLKMAPCIPYLGIYLFDMTYIDSAYPASDSIIETEQRTNQMNNLLRIISDLQVSCKYDHLITLPHVQKYLMSVRYIEELQKFVEDDNYSLSLKIEPGNSSPRLVSSKEDLGGPSEVSMSVRYNRRPTCPDTSVVAHLPTPPPARHRKSHSLGNNMMCQFGVVESKSATFPEKEKARHLLDDSFLESHSPVRNHTHDSVFTNGISLGSRESSFSDELSSTVERGRMYATLGPNWRVPICNSPRSRSYIYSTPGAVSSYECSTLSSITIEGPLRRKTLMKEGKKPTLSSWKRYWIVLSGSILIYFGSKALRANERRHYKSRPCKKITLTGWMVVLPDNPEHPNIFQLTDPDRGNVYKFQTGSRFSAIIWHRHLAEACRSTRPQMPANLMSFE
The following text describes a protein:
Function:
Involved in the spatial control of cytokinesis by a proper phragmoplast guidance. Localizes TAN to the cortical division sites (CDS) during cytokinesis via direct binding.
Subcellular Localization:
Cytoplasm, cytoskeleton, phragmoplast.
Sequence:
MSRNVPRIEMPESEENEFASLSLFSPSRPPLNSIPDPSQIQKANHLPHFDLVQKLEGTRAQHQRTLGPEKKFEVLEGRAGNSSDSNPKIVNRNGKSRSEPNSAQSTPTRNGARVSLGGGCATGARFLQSFGGRGRIPRGVSIAESVSFAETTPHFELNEDHSFWKDHNVQVLIRLRPLGTMERANQGYGKCLKQESPQTLVWLGHPEARFTFDHVASETISQEKLFRVAGLPMVENCLSGYNSCVFAYGQTGSGKTYTMMGEISEAEGSLGEDCGVTARIFEYLFSRIKMEEEERRDENLKFSCKCSFLEIYNEQITDLLEPSSTNLQLREDLGKGVYVENLVEHNVRTVSDVLKLLLQGATNRKIAATRMNSESSRSHSVFTCTIESLWEKDSLTRSRFARLNLVDLAGSERQKSSGAEGDRLKEAANINKSLSTLGLVIMSLVDLAHGKHRHVPYRDSRLTFLLQDSLGGNSKTMIIANVSPSLCSTNETLSTLKFAQRAKLIQNNAKVNEDASGDVTALQQEIRKLKVQLTSLLKNHDSCGALSDCISSLEESRYSGTCKVAGETRQDKCHCQVKNMNDNMIGALRREKIAESALQKSEAEIERIDCLVRDMEEDAKRIKIMLNLREEKVGEMEFCTSGSLMTKECLIEENKTLKGEIKLLRDSIDKNPELTRSALENTKLREQLQRYQKFYEHGEREALLAEVTGLRDQLLDVLEAKDESFSKHVMKENEMEKEFEDCRNMNSSLIRELDEIQAGLGRYLNFDQIQSNVVASSTRGAEQAETMPTISEIQEEVAISHSKNYDRGALVKTDEGIDRSILQFKLGKLMKDLEEARTLNCKYEKDHKSQLSQQEDIEVVREQVETETARTILELQEEVIALQSEFQRRICNLTEENQSIKDTITARESEIRALNQDWEKATLELTNFIVAGSKSIKNASTQIESIICSFPQVNAWIGDYVEKAAKNCIKKEETILLLQKSLEDARILVAEMNLKLNSLKGATIALNEFQLGGNAATTEEAFNLNNDVDRMSDEVDTLESNFKANQYSILKTERHAEAALAVTKWLSDSRDQHQMMEKVQDQSVKEFGTLSSISASLSAEGNADISLSRDGHLSDATYPKGDELSTSSSDFSNCRWQHDCALNVKCQGVSSSESDAQESNNKITSAALIAKNGSAHSVYCGEGRQSVEKPLTIMMGREETEYKCSKPLSSGVYMGLMQRMDPVRTFFDRFEEVNATMKEADLTICELVKANEKSNSVTEMWLQTHEELISKEKNLMDDLEQVKSILSACEEEKQVLLNQTHTTLADMENSVSLLEEYFQEMKRGVEETVEALFSHARLAGKELLQLISNSRPSLEQIASEFMEREFTMYATYQCHIGKLIDQILDQRKQVITPNLSGQETNQSVKINAIGYNAEDEVTKKQSREEIVTGLENDEVVQSHESLLYENLYLKKELERKEALFEGLLFDFRLLQESASNKRDIKNEMDELFDALCKVQLELELKASQVHELFVHNENLENCSIDLKTALFTSQSDLEQAKQRIQILAEQNDELRALVSDLCKEKAAAEEGLDEQRDLVNRLEKEILHLTTTAEKQLLSAVKSIKENLKKTSDEKDQIVDEICSLNNKLELAYAIADEKEAIAVEAHQESEASKIYAEQKEEEVKILEISVEELERTINILERRVYDMDEEVKRHRTTQDSLETELQALRQRLFRFENFTGTMVTTNESTEEYKSHISRSTGLQGAHSQIQVLQKEVAEQTKEIKQLKEYISEILLHSEAQSSAYQEKYKTLEVMIRDFKLEDSSSSAAETISHKTEKSSTRSRGSSSPFRCIVGLVQQMKLEKDQELTMARVRVEELESLLAVKQKEICTLNTRIAAADSMTHDVIRDLLGVKMDITSYAELIDQHQVQRVVEKAQQHAEEILSKEQEVMNLKRHIDYLFKDRESCMSELNKKDTDVLATQISLDQLQERVQLLSMQNEMLKNDKSNLLRKLAELDRTVHNAQASNHRVPQTTKDTASFKLADTDYTKRLENAQKLLSHANNELAKYRKTSNNHPSTRTQGQSSGTRYR
The following text describes a protein:
Function:
May regulate neuronal differentiation, polarization and axon guidance.
Sequence:
MGIFQLFLVLCIFFASSVVGFGVDPALRISVFDELRLGDGFDGLTQVQGFHSETRAFHFQGSSREVRASAEVSAQMLKKLKGKNEFTVLATVKQDRLNSGVILSVHQSDHRFLELESSGQRSEVRLHYRTKNQKDHTEVFPYSLADDQWHKISVAVSASHVILHVDCNRIYERVVEAPSMDIPEDTSFWLGQRNAAHGFFKGVMQDVEVLVMPQGYISQCPDLNRTCPTCNDFHGLVQKIMELQDILAKTSSKLSRAEEKMNGLDGCYCERTCSVKGVIYREDEGWTDGCKNCTCTNGTVHCEAISCPPPQCPAGTAPAYIKGACCKECQPVCLFGGRELVEGDQRAVRDSSGRCLLFECRDRSMHRVVPSEPCPELSCPESEQIALSNRCCKVCRGHDFCSEGHGCLEHSDCVNLEAGDCCVCKDGFRPLRDDNAYCDEHDECLSGLHNCDENALCFNMVGGHSCSCKPGYTGNGTVCKAMCDGLCQNGGTCVSPNKCVCQQGFTGSRCETDIDECADGFVECDSKSTCVNLPGWYHCECRDGYHDNGLFSANGESCVDINECKTGRNTCANDTVCFNLEGGYDCRCPHGHNCTGDCIHDNKVKHSGQIWVLDNDRCSVCSCQAGQVMCRRMVCDCDNPNADLFCCPECDPRLSSQCLHQNGLLTYGSGDTWVENCQQCQCLQGQVDCWPLPCPPVDCEFTVVPEGECCPRCVTDPCQADTIRNDITKTCTDEHNISRFSGSSWIKHGTECTLCQCKVSRHRQIPNCKLHLTSLSQRNPFFFFAMKNPFQRKTKVVSLGLNICTLNGISASLQNDCSSANTKR
The following text describes a protein:
Function:
Possesses an intrinsic protein tyrosine phosphatase (PTPase) activity. Regulates egl-15 activity which is required for hypodermis-mediated fluid homeostasis and protein degradation in muscle. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine. Regulates synaptic levels of nAchR subunit lev-1 in the nerve cord. Promotes the outgrowth of the quaternary dendritic branches of the PVD sensory neurons. In parallel to the sax-7/mnr-1 pathway, also controls the extension of the PVD primary branches. Acts in the netrin/DCC pathway to mediate the formation of synapses between the AVA interneurons and the PHB sensory neurons. Also required for the formation of synapses between the AVA interneurons and the VA10 motor neurons.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Synapse.
Domain:
Tyrosine-protein phosphatase 1 domain has enzymatic activity which is required for the negative regulation of egl-15. Tyrosine-protein phosphatase 1 domain is required for correct PVD dendrite formation. The second tyrosine-protein phosphatase domain has no phosphatase activity and appears to be dispensable for clr-1 function. Isoform c lacks both tyrosine-protein phosphatase domains and is likely to have no catalytic activity; The extracellular domain is required for the formation of synapses between the AVA interneurons and the PHB sensory neurons.
Sequence:
MRINRWIWWATVILLYLRTGLAADFFRSSEENDRKSSDDLDNFNSTKIEPDKPKTAKELGVKSCESNQDCVHDGVCHRGNDGHGICMCPRSCPAITPKQCGYNYRTPSTCLLMDADYRSKYDVKEPTCYSRKCVCPPQFDDVHVTANQKPLRLNSTLLPTKCDKRDLAVVARAHPSTSVSKGIDVTLFCCINVDPEGFIDVASVFFIQNGTIMREATSHPFAPRNGLARRVHEKYSCWELEIKNAQTSDSGSYMCRVTASASDLDVTDTMQFEVKAPRQIKNLTVNPSERDAIVTWESEGGEDMAIDLRLVRRTDTRGQVVFSKDNLTSPVSIKDLRAATPYTLFVSGNNGQVPFEFTEHFTTKQKRPFPPKEEDVRVLNSGSALSCEVEWKSPAEPNGRITKYFVSVRGAMRKSDGSLTPDDLPAAVEVDKRCANWDGDENTSKHNGINPIDFANEFYSCKFGPLKPNRNYTVTVWAENSAGRSLPAVFHKNCVTNYAQPDMVETPQPLLSNNHSTFSLTFPQPPDDINGPISCYYIAIVPLPANVSLDILPKSEEIVMHSFSKVFTNNLLPSSAEEKRFFAYIAESYVQLPEETTIGDGVRVSDLKACNVQYLSRYSSEDLALRRGLKYTGFLIVRVDKEEELNRKDVRNGADPNIFRNLIDKSVSPTSRTRTASPMSRHLRQLHLSGPAYGYSAYFKPILLDTESSSSGFGIFMKIILPFLLFLAFATGVTMFFVNRKGHMLSTWCPLFTKMTSKDVVERTLLKQTFGAIPVDDLPTEYVVRHRDTDFLFAQEYESLPHFQLDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIGECGPDVIPNGNGVEYANVPIVKGQFANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWHMYGDTDEDVRDFEDHYQRLCASNRDRAVSFNQQSSTNGSISPRVAIVSSRESMTTSNGETGLEEEFKKLERNLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFFDYIAAQDPVSEGTAFDFWRMIADQNVTTVVMLSDETDWSDVEKYWPIDGSGTECHFGSERNSVNVTCVSEEHHQDFIIRNLSYSMKDNESMPANQEVVQYSYTGWPSDSIVPKSANSLMNLIEMVLQRQSSLMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISKTYR
The following text describes a protein:
Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MKQQQQQEDGGGGPQSTKTGPVSLSLSLSVCLCVSRCVCLSVSLCLSQVLSVVAVESSDISVLFFFFQVWGVKMYRGYPFDPIRTRERRERERAKNHWMTNGSIIPNGSECDSFRQFFAAAKTPTRKMAKAQNQGKSTLWASILANVASKTTTRHLPSKNVVVLGDEGTGKSSFISRLQGNQKYDPKDHPMGTGLEYTYLDVRDEETEDVVGRLGVYTLDGNIEHAPLLDFVITPESISDLVFVIVVDMTKPWDIMRGLKRWLGVIEEYTASLYRSSTTSAPAGTDDSAVPVDGEGAVTGGDADATDAATTSARQELDAREAVAKQLTEMREKLARYVQDPTLAENTLLELEDGVLTTNLGVPIVFVVNKSDAMAALRKDRDYQGQHFDFIQLHVRRLALAYGAATVYSCKDASNNTAVHRYLVHRAYVGDDLTRHRFPFRAEDASNDPETFFMPSGVDSAAKIQVLEDGLKTISANDEYEEQIFPPPTSEEKEVLIEVKDEQEFLKEQQAVLGKTQLSAGVGRRQNLSLDPRRNKDTKVTMSTLKTGSLGAAPAPSGGGASAVTSAPTTSAGPVAATPAAATAAPKLSAPKPSAGLSAGDKPASAATPALSGMPGGVGADGKANNDMLASFFSNLLSKSNSTAAGGAGAAKK
The following text describes a protein:
Function:
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
Subcellular Localization:
Cytoplasm.
Sequence:
MASISDGNTDALVARFKVLEETVGKQHKENRALKKKVQSYHSLNSLYHEAKQEVNSLKQKLLLKESLIQKLMVSQAALGVEEHQVSSSKSLVESLVEQLSLMKSKLKETERTCQEKVESLSQEIKRLHRQLEDKDTQVLQYASWPQHEKELEICRLQQTLTDKERAQATSEVLCQSLSDESQQLRRKLATTAEMCQQLVKCLEETQRNSTRNVEQPVHTERPNKILNLDGSNESSLSKLQEENRLLKQKVVHVEDLNAKWQKYDASREEYVKGLHLQLKELKARSDLKSSHSAHTHKELLQKEIIRLNKLLEERMNECTKLKQEKEEMAGARIADSERIQVLEQQLLVYKDDFISERSDRERAQSRIQELLEQLSTLQRQTRRMEDRETAGNFHIFISNKNKTFVKKNTTEALRGSSPEHTEGRRQVAPAEAAEAHRNSTSERRGQDELQCPRCFRIFKDRLGDNLLEHISECCQ
The following text describes a protein:
Function:
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.
Sequence:
MARHVFLTGPPGVGKTTLIQKATEVLKSSGMPVDGFYTEEVRQGGRRIGFDVVTLSGIRGPLSRIGSEPLPGKRECRVGQYVVDLTSFEQLALPVLRNAGASGRPGQSICVIDEVGKMELFSQPFIQAVRQVLSIPGTVVLGTIPVPKGKPLALVEEIRTRKDVKVFSVTKENRNHLLPEIVTHMQSSRK
The following text describes a protein:
Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MTNSSKVQSKSPYKTVEVVFIVLVAGSLSLVTVIGNILVMLSIKVNRNLQTVNNYFLFSLACADLIIGLCSMNLYTVYIVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLSYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGGRTVPEKECYIQFFSNAAVTFGTAIAAFYLPVIIMIQLYWQISRASKSRVKKDNRKPSGANPEPLSPVQRRSSTPKPNNNNVPGEDAGHSQNQKLQNGKGPSSTTNCTPGDEKESSNDSTSVSVVASNQKDEEPAPSTANSCAETSQQIPRQRAKAGGSKLTCIKIKTKSPKGDYYTPSNATVEIVPATERQNHVARKIVKMTKQPPNKKKKGAPSREKKVTRTIMAILVAFVATWTPYNVMVLINTFCSSCIPNTVWTIGYWLCYINSTINPACYALCNVTFKKTFKHLLMCQYKNIRSAR
The following text describes a protein:
Function:
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Sequence:
MPFTGATRVLGIIGQPVSHSLSPLMQNAALQAMGLDYAYVPFAVEEDCLADAVRGLAALGVVGFNVTIPHKSAILPLLDRLSPEAELIGAANVVKREGSDLVGYNTDGTGFIQSLSEDLGFTPAGCRILVMGAGGAARAAVASLAGAGAASVVIANRSIARGEELSAAFRRHFIGTQFAAIPLDPENLNRCVQNFDLLVNTSSVGMGGTAFPGMDLSRMGPHGAVYDMVYVPAVTPLLAEAERCGIRYANGIGMLAAQGECALELWTGVRPPEGLMKACLMAALMS
The following text describes a protein:
Function:
Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MDPKYFILILFCGHLNNTFFSKTETITTEKQSQPTLFTSSMSQVLANSQNTTGNPLGQPTQFSDTFSGQSISPAKVTAGQPTPAVYTSSEKPEAHTSAGQPLAYNTKQPTPIANTSSQQAVFTSARQLPSARTSTTQPPKSFVYTFTQQSSSVQIPSRKQITVHNPSTQPTSTVKNSPRSTPGFILDTTSNKQTPQKNNYNSIAAILIGVLLTSMLVAIIIIVLWKCLRKPVLNDQNWAGRSPFADGETPDICMDNIRENEISTKRTSIISLTPWKPSKSTLLADDLEIKLFESSENIEDSNNPKTEKIKDQVNGTSEDSADGSTVGTAVSSSDDADLPPPPPLLDLEGQESNQSDKPTMTIVSPLPNDSTSLPPSLDCLNQDCGDHKSEIIQSFPPLDSLNLPLPPVDFMKNQEDSNLEIQCQEFSIPPNSDQDLNESLPPPPAELL
The following text describes a protein:
Function:
Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDSSSRRRRVPLVDMLSVMFGVGAWISINGLWVELPLLVQALPEGWSLPSFMSIIIQIANIGPIFYSVMHLLVPHIVHEKPSIYVLMVIGVLSSLLMGFFWDATSYINGEEHSTGLLTLLFFLSLVDCSSSVLFMPFMARFRQAYLTSYLIGEGLSGFLPSIFALIQGVGGNPSCRNTSTIVNGSESWQIEAFYPEPNFSVSVFFFILMGLMVCCAASFIGLNHCGVARQERYESVATRIPVAIDNQTFVASTEIVDPTFNGKSAKINCQVELDSVSEEQQLVNTDIPKSVFIYLLLLQAWVCALSNGALPSIQSYSCLPYGNTAYHFAVTLSAMANPLSCLIAYFLPITNVCLIVVFSFLGTSVSAYIIALAALSPTPPLVGYPSGETLMILSWILCVGLLTYVKVSIASLFRMEEGKGNRNLFWFGVFTQVGSAIGSIIAFLLVNVYQYFDAYYPCT
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide. Required for photosynthesis in cotyledons. Binds salicylic acid. Together with BCA4, involved in the CO(2) signaling pathway which controls gas-exchange between plants and the atmosphere by modulating stomatal development and movements. Promotes water use efficiency.
Subcellular Localization:
Plastid, chloroplast stroma. Cell membrane; Peripheral membrane protein.
Sequence:
MSTAPLSGFFLTSLSPSQSSLQKLSLRTSSTVACLPPASSSSSSSSSSSSRSVPTLIRNEPVFAAPAPIIAPYWSEEMGTEAYDEAIEALKKLLIEKEELKTVAAAKVEQITAALQTGTSSDKKAFDPVETIKQGFIKFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFQPGDAFVVRNIANMVPPFDKVKYGGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNNSTDFIEDWVKICLPAKSKVISELGDSAFEDQCGRCEREAVNVSLANLLTYPFVREGLVKGTLALKGGYYDFVKGAFELWGLEFGLSETSSVKDVATILHWKL
The following text describes a protein:
Function:
Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
Subcellular Localization:
Cytoplasm. Note=Membrane-associated.
Sequence:
MASLREDMFGQASGDFAVDLGTTTTRVYRRGAGIVLSQPSMVAFRRGDGGPARLLDAGSGARRMFGRTPAGIDVVRPLREGVVVDPAAGAHMLRSFFDSIPGCAHRSLRIIIGVPAGGSGRDRDNARAVARMAGAGEVYLMEEPLALAIGAGADAADLWGTLVVDVGGGTTEVALVASGGIQCLRSVPVGGDAMDAAIVGYLERERGVLVGERTAEELKIRLGAATADSPAERARVRGRGVARGLPVEISVSSREVCAALRAPVAAIVAAVRSCLDGIPPAVSLDLLDRGILMGGGGSLLHGLDRALEREVLLPVTRVSDPFSCVARGSAAVLDYLGVLRRVERG
The following text describes a protein:
Function:
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.
Subcellular Localization:
Nucleus.
Sequence:
MEEEFKDKGLPPTLLHLIPDGREWKVKEADGEGSRNTNLDADEDKELELKLGLPGVQQEERAADSREKIQQQQRESSSEPSIGCFPTHSKPTTSIGTTGAKRGFFAIVGATLEGYNQSHRDTEECGKELTLGDENMAGERKKGCCPSPPCSAAAHSSNPQGRGAIPPVVGWPPIRSFRRNLTNGSSFKQSPERQNDEADDKAKPICKKRPLVKINMDGIPIGRKVDLQIYDSYQKLSSAVEELFRGFLEAQKDLSCAESGEQGAEDKIFSGLLDGTGVYTLVYEDNDGDRMLAGDIPWKVFVSTVKRLRVMRRSELPHDMIGADPVK
The following text describes a protein:
Function:
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (By similarity). Required for rRNA maturation (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Nucleus, nucleolus.
Sequence:
MSTKIIKASAAEPDVFETSISQALVELETNSDLKAQLRELYITKAKEIELHNKKSIIIYVPMPKLKAFQKIQIRLVRELEKKFSGKHVVFIGDRKILPKPSHKTRVANKQKRPRSRTLTSVYDAILEDLVFPAEIVGKRIRIKLDGSQLIKVHLDKNQQTTIEHKVDTFQSVYKKLTGREVTFEFPEPYL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
Subcellular Localization:
Cytoplasm.
Sequence:
MTIFKETVETEPLTVSEAKALLSEVETERALDEDRELRFELSRAIEHANRFALLEPAESREFVDELLALDVLDDEAVAYKIVDLLPRTRTELRSVFANERYAMSGDELDEILDVVAKYV
The following text describes a protein:
Function:
Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MFGALTAYLQFVASNTWSPTPHYSPWNDLSTKERSDSEREYKGQANLHIFEDWCGSSVDQLRKNLHYPLFAHTRTTVKKLAVSPRWTNYGLRIFGYLHPYIDGEYQFAVASDDNSEFWLSSDDQPLNLSLLAFVGKTGKEWTAPGEYEKYTSQISRPVQLKTMKKYYFEVIHKQNDHGTDHVEVAWRLSNSGLKFTVINSNYISLYKNESSLKMSEVSHVPQSTASHVRSYSEMQQTTSHGAEMLREDPRDTFFQVPMIDSSYLRRVLPDCTYKPTYNIKGFPLLRYQGLQFVRMSYVYPNDYTRLTHMETENKCFYHENPYYLEKFGFFKYMKMDYEDEQNPEPNPVKQITAKEKPMQDYGDDYDDYNFRRRQKLFSLPPSTKVQVDQQLRRRKRRIENDVQNPVDVVEQKGAGKRKVRVVKTKKIKKLKKTTQSFKAGSKYSESTPVPFQEKKIPRKMELEKVKQKVPIRRSVTNESQPAFHLSPNSRNLVLPKSDYVKKTMIDFHVSKNASLPTSIQDPPRTYNMSRKGNRSSRTEKKILSADLKKTGTTRKKTHLLVLTGEKEGMQEAQVGLETKPRRDEEENQVTGNIQLPYISRVQRRAEDKSPLDVPDDELANNRVWMQPEVDSNMEEDGMKEEFATVDFYDQDVNWDQTFDVNHLDFHALRSDWIDLHCNVSGNLLLRELDALPVVEAYMRKLNERNNGVFSLERVVNVEKHLDGWQGSRYLLELELLESGKRRVRLAQYVYVLNQRGRNRSLRVPAGKEPPLRPGRSHSSEELLLCNPLGFSWRESATVHFIVPVKNQARWVRQFIVDMEELYRVTGDKNFNVIIIDYSSTDMDVEQALRTSALHRYQYVQLTGNFERSAGLQAGINLITDDHSIVFLCDLHIHFPASIIDSVRKHCVEGKMAFAPIVMRLNCGATPQEPDGFWEVNGFGLLGIYKSDLDAAGGMNTLEFRDRWGGEDWELLDRILQAGLEVERIYLRNFLHHYHSKRGMWNRRLFRST
The following text describes a protein:
Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
Sequence:
YNENKGSSSHSEDKRNRSGERGRDGYHGGGGGGARQNHQRVQVIGKELVRIVRHGKYNQQIQMDAEGYVFVNDILTCKRFYDQFPGVNELYIEKIVESNDKKRFELKFEEGVGWKIKAAQGHTVKIENRSLRPITNPAEFPVVIHGTYWENWEFIKVNGLNRMGRNHIHFAPGLPNEVVSGMRKSCEVAIYINMTQALKDGFKFFQSSNQVILTEGDEKGRIHPKYFLKVVQLYPRKGIKFEI