lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
Subcellular Localization:
Cytoplasm. Early endosome membrane; Peripheral membrane protein.
Sequence:
MLRRILQRTPGRVGSQGSDSDSSATPGNVLDVNNEGSSEGFICPFCMKNYVAATTLLEHYQKEHREKECQDQTLLNDSLVAGFICPQCMKSHGSAEELFKHYQAVHDSGNESSHGGEALKREDVILLRQEVQDLQASLKEEKWYSEELKKELEKLQGQRQQELKPDGLATDSSAELQSLEQQLDEAQTENFNIKQMKDLFEQKAAQLATEVADIKSKYDEEKGLREAAEQKATSLTEELKKETTVIQDLKTELLQRPGVEDVAVLKKELVQVQTLMDNMTLERERESEKLQEECRKLRADCVNSEVTISQLRNELAKGPQEVAVYVQELQKLQSSVNEFTQKNQNLTEKLLKKEQDYIQLEEKQNEEYICKKNIQANLHQKELDCQQLQSKLSSTEASLQRLQGELVEKGDVSQKLKEELSEVESKYQHLKVEFKQLQQQREEKEQHAFQLQSEVNQLHSKLLEAERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQFDKMRQQHQEQQALQQSTTSKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENITLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHEQVQEQKAHLRAAQDRVLALEANISEVNSQLNESKEKVSQLDLQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEFNKISNQLDEVTGQLHDKQEHCIQLEASIKELKEKKLSYEQRAEELEGQVKKLDSDILEIKASKEQIVHDLQEQRQQNAELNLRVAELSQQLEAEREAVSNAHLDLRKKSDAFEHATQMLSKHEEEKAGLKQELQKLHHDAESQRKELDSKVQATLTDLQQVKKERASLEKELSTTKDKLLKTSESLKDTKNEIEKERQSGKIALAELEKTCKELKHQLQVQTECSIKEKNELKKLFEKEKEVTQQLKLDLSSTQEQVLHVQNILKEKEKEEEQLQGKLNSLKQLLEQRKKQTEGLQEEMKITLSQKTELENKLQQQITLSCQDLAAERDKISALQSTYEKSQENLKQLQSDFYGKESELLATRQDLKSVEEKLSLAQEDLISNRNQLGNQNKMIQELKVAKTSLQQDVAKKEQQLQEQSETLQAMQKDKSLKEKELANEKSKLMEIQEIKGRQEKEIAKLSEELGSCKQESLKEITNLKDAKQLLIQQKLELQGKLDALKSTLEQEKKKQQIVKDQLKKTEDDLRKEFTEKEAKLHTEIKEKEEKIKKHEENETRLAMQVTALNENLSTVKKEWQASQRRVSELEKQIDDLRGEIAVLEATIQNNQDERRALLERCLKGEGEIEKLQAKVLELQRKLDNTTAAIQELGRENQSLQIKHTQALNRKWAEDNEVQNCMSCGKSFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDDCFNDLQG
The following text describes a protein:
Function:
Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.
Subcellular Localization:
Cytoplasm.
Sequence:
MEASMKIKEIIVVEGKDDTVAIKRAVDADTIETNGSAIGDHVIEQVKLAQQKRGVIIFTDPDYPGERIRKIISDKVPGCKHAFLPKEEALAKRKKGVGIEHASNESIRRALENIHEEMEAYTGEISWSDLVDAGLVGGEMAKSRRERMGKLLKIGYTNAKQLHKRLQMFQVSKESFAEAYKQVIQEEKK
The following text describes a protein:
Function:
ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle; Receptor for ATP that acts as a ligand-gated ion channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAAAEPKPPAGADAARRLAGGCWSALWDYETPKVIVVKNRRLGVVYRAVQLLILLYFVWYVFIVQKSYQDSETGPESSVITKVKGITYSEHKVWDVEEYVKPPESVRVSNATCDVDEDCVSGQLDMLGNGLRTGRCVPYYQGSAKTCEVSGWCPVEDGASVSQFLGKMAPNFTILIKNSIHYPKFQFSKGNIEHRKDGYLKHCTFDEVSDLYCPIFKLGFIVEQAGENFTELAHTGGVIGVVINWDCDLDLPASKCNPKYSFRRLDPKHVPASSGYNFRFAKYYKTNNSTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSIGVGSFLCDWILLTFMNKNKVYSHKKFDKVCAPRHSPGSWPVTLALVLGQAPPPAPPCPADPSQACQALAVPPPPKQMVDTPASEPPWQDSTLADPRGLAQL
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAASTAKIVIIGSYNRDLVWYVKDFPIGGQTINGSFASSHGGKGSNQAIACGKVLRDPSRAFFVGAVGKDTFGDEILAHYRELGIPNCIKQVSGAPTGNAGIYVAESGENMIVISEGANGMLKPSLVPDLMAVLVKATLVVMQCEISPDNTLLFVEVIKQAKAQNSSLRFVFNPAPYRADYDFSKILSITDIFCPNELEALEISGTGRLEGICDDSMMKALVEKMSSLSPSLKFVLFTLGSRGSRIVQTKSYESRTVGIYSHGRAIDTSGAGDCFIGSFCVRLMELAEESTRGPSALNDIDTIAEAARFASVAAGISVTRKGTSASVPRRQEVDDALSKFSGK
The following text describes a protein:
Function:
Specifically methylates the N7 position of a guanine in 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MDSGALWQDLGWQPDTLQARSFERLYALVLAGNTRLNLTRITGREEFWEKHLFDSLRGLAAFQDQKEPSLIDIGTGAGFPGLPIAIAHPDWYVVLVDSVRKKIAFVLSTIQALGLTNAQALTGRAEDLAHRREHRESYDLAVLRAVAQANVCAEYALPFVKLGGAAVLYRGNWEVQEEVELARACRALGGEIVEVDAFELPVSRAVRHCVVIRKTGPGLRVFPRPAGLPTQHPLGAIEGAPRVESEEPEEP
The following text describes a protein:
Function:
As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation.
Subcellular Localization:
Mitochondrion.
Sequence:
MRPNLFSGASRLLTYSRNGKLLTRGRSTKATSSSLDSQHQDAATTEGGRAESVEESPEQQRKLPTREPLAKNFFIGVVDKELLAYPEVIPRDEMAQLENSLLPLKNYFVEPRETEETSPETLRQLGLYGLNVSTDYEGKGYGWSASLMASEPDSTDINVTLGLQTHRVVVDLLKEVGTPLQQQRYLQDLATGKLIGTEAIYEISPPEEDYFNTTAELFPEYGKWQLNGEKSFVICTPGERQLFLVLAQTQQPNVPGVLGRGTTIFLVDSQQEGVRLGEKHATFGCRKAEIRRVHFEGVKLGEDQVVGLPHDGNRYSEQLVRSSRLRGSLVGLSLAKKLLNELAQYTVNTTQCGVQLQDLELTRIHMSRAMCSVYAMESMLYLTAGLLDEFRAQDVTLESAITKYFTLRQVYAIASQNLGVVGPKSLLSGETTELGLRDAAQLCTQGESLDTLGMFIALTGLQHAGQAMNTGVRKSRNPLFNPGHIFGKFLDNNSIDNPKTKMQLSEHVHPSLEAAAQCIELSVARLQMAVELMFTKHGNAVVERQSEMQRLAEVGTLIYAMWASVARASRSYCIGLPLADHELLTATAICSEGRDRVRTLCTEIYGGHFVNNDNNLVRLSKQVAKSKGYFAVHPLTFNF
The following text describes a protein:
Function:
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MLDASGCSWAMWTWALLQLLLLVGPGGCLNRQELFPFGPGQGDLELEAGDDVVSPSLELIGELSFYDRTDITSVYVTTNGIIAMSEPPATEYHPGTFPPSFGSVAPFLADLDTTDGLGNVYYREDLSPFIIQMAAEYVQRGFPEVSFQPTSVVVVTWESVAPYGGPSSSPAEEGKRNTFQAVLASSNSSSYAIFLYPEDGLQFFTTFSKKDESQVPAVVGFSKGLVGFLWKSNGAYNIFANDRESIENLAKSSNAGHQGVWVFEIGSPATAKGVVSADVNLDLDDDGADYEDEDYDLVTSHLGLEDVATPSPSHSPRRGYPDPHNVPRILSPGYEATERPRGVPTERTRSFQLPAERFPQHHPQVIDVDEVEETGVVFSYNTGSQQTCANNRHQCSVHAECRDYATGFCCRCVANYTGNGRQCVAEGSPQRVNGKVKGRIFVGSSQVPVVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPIGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFLGHPGKLVLKQQFSGIDEHGHLTISTELEGRVPQIPYGASVHIEPYTELYHYSSSVITSSSTREYTVMEPDQDGAAPSHTHIYQWRQTITFQECAHDDARPALPSTQQLSVDSVFVLYNKEERILRYALSNSIGPVRDGSPDALQNPCYIGTHGCDSNAACRPGPGTQFTCECSIGFRGDGQTCYDIDECSEQPSRCGNHAVCNNLPGTFRCECVEGYHFSDRGTCVAAEDQRPINYCETGLHNCDIPQRAQCIYMGGSSYTCSCLPGFSGDGRACRDVDECQHSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCMPGEVSKTRCQLEREHILGAAGGADAQRPTLQGMFVPQCDEYGHYVPTQCHHSTGYCWCVDRDGRELEGSRTPPGMRPPCLSTVAPPIHQGPVVPTAVIPLPPGTHLLFAQTGKIERLPLERNTMKKTEAKAFLHIPAKVIIGLAFDCVDKVVYWTDISEPSIGRASLHGGEPTTIIRQDLGSPEGIALDHLGRTIFWTDSQLDRIEVAKMDGTQRRVLFDTGLVNPRGIVTDPVRGNLYWTDWNRDNPKIETSHMDGTNRRILAQDNLGLPNGLTFDAFSSQLCWVDAGTHRAECLNPAQPGRRKVLEGLQYPFAVTSYGKNLYYTDWKTNSVIAMDLAISKEMDTFHPHKQTRLYGITIALSQCPQGHNYCSVNNGGCTHLCLPTPGSRTCRCPDNTLGVDCIERK
The following text describes a protein:
Function:
Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Sequence:
MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAELVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASSSLQLVFGIELMEVDPIGHLYIFATCLGLSYDGLLGDNQIMPKAGLLIIVLAIIAREGDCAPEEKIWEELSVLEVFEGREDSILGDPKKLLTQHFVQENYLEYRQVPGSDPACYEFLWGPRALVETSYVKVLHHMVKISGGPHISYPPLHEWVLREGEE
The following text describes a protein:
Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAESSDKPEEAAEATETVPSVAVITDEERELAGKALLQFESGKYDAALNTISRLEETRQNDHKVLHNRAVVEFHKSNCTKTDEFRQRLQTVCSQLSIKVNDLDGLEDVDNGVLYYNQAVVRFHTRQFQEAANILEKLFQFIEPLEETLARKIYMVLIDLYLLTYQAEKALHMVSYFDKMLFDPPSAGKSKEGAQDKDKDKEKDKTPESGATPAAAKETAIETVSPNEEFRPLLHQYKARCCLLAKSIKACKREIKAVINTQGMTSTTIFLKANFEYLRHNYRKAVKLLSSIPDAPRMMELGEWIPVMFYNNLGCIHFYMKKYNLGAFYFKKAMQENDNRAQQLPKRESGQILSGRPLHTLATNKHYELLYNAGIQLLHAGRPLAAFDCLIESVQVYHSNPRLWLRIAECCIAANKETPEEESRGIPSKKQMSSQGVVGSGFHRKLVVMSPSQKGNKFTGPSGQSSAIPVANLEFAAICLKNAAMLLPEEAGTKDAGSAGHAGTGVQLGGHSLDSGDMFDGSLPGDSGCVAAPPGFPLKPLQAASLRCSVLACSAYVALGLGDNVTALHHAQNLLTQPSLSGSLKFLGHLYAAEALISLDQVSEAIQHLNPDNISDVSVSLPGTVDTTAEKGKGSDEGEERESQEALMFTFFPTAVHSQNYPHSLQSAKATLMFNLASAHCLRSEFEKAKKCLHQAASLIPPNEIPPQAIMLGVYLELQSGNTKLALQIIKKNQLIPLLKGSDSNAPLPASNTPPTPLTRAKQKPRK
The following text describes a protein:
Function:
Involved in post-replicative DNA-mismatch repair.
Sequence:
MSKKLNTSVGGTPTNTLLNYFSKSPAFDKKKLTPSVKTDPDASKSEKENLQNQQPKVKDGKKEASKPAAKRKLPISDDEPASGQRKRKRIVQPESDSEPEMEVTKSEDDFSDCASDYEPDENEASDDSVSSGAEEVSPSENDMSVDSPTPKKSRKKSKILNNNNNNEPSSKKVKLESTIQLAEGATFQEKLKNLQSNAKQDASYDDIVTNTSNLDEPVVWPHQKLEFLQPDKIKDKEGRRPDHPDYDKSTLHVPEKFLNGLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYHMDADVGVNELGFTYMRGEFAHSGFPEISFDKMSTILVDRGFKVARVEQTETPDMMTERCKRIKATKFDKVVAREICQITNRGTQVFGSQCKIGPNHQPNYMLAIVEKDEGTCSRYGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEKSALSQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYYAGPGSDDNWPLVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVASTLRRSHMVLDATTLSNLRIIGEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIGELIRMPTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKGFNDLTKLPTMFHQCKTTLLKRITQLPESGGSFPDLSKELQYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHFGCRITYFGSDKKRYQLDVPESHASKANKSYTLEGQTKGKKPSRRYTTAETRALLKDMQHAEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYAGQQMVICVPELVSDADQPFIQLEEGYHPCANASTYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAASVVNFLANLKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVENEDNADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEAIALQRKITAKIVAATAGNEDTKKEKINALKDLLKQLKMCQV
The following text describes a protein:
Function:
May play a role in organizing the actin cytoskeleton.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MANEACPKAGDSPFSSDKHAQLILAQVNKMRNGEHFCDVQLQVGKETFKVHRLVLAASSPYFAALFTGGMKESSKDVVQILGIEAGIFQILLDFIYTGIVNIGVNNVQELIVAADMLQLTEVVNLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFTENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLEPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARCGLGVAVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERYDPDENKWEVVGNMALSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL
The following text describes a protein:
Function:
Probable phospholipase that hydrolyzes phosphatidic acid.
Subcellular Localization:
Mitochondrion.
Sequence:
MILYIVLPFYVRTKPYSILPSYSSLQWITNAWCSLPSIYILCHCSKHQEEITILALKPLIAMNNSEEWPLKHVQPPKLSFRHLLSRSVTDAPSLRVRWFYAVDRPLRKSRTGPTEIKKAKNFLPFSAEDSEHIEKSYLKAVENDGQSEPVNVNEDYLYSVNVVSRELSPIYWDGPVYRILRGTWFFSRGDKLYPCEENLATQVEEGYLNSCPYREFSNEKDSAAAQSKTWALLGRYTGGFVQYTGSRNARLVYDDFYRNVSVKIMNRFSPASFHRSDKLVRGYELDMLESNSKPSTPVPTEELTSTTLLNDSSDPSDNFTPSNTESTIDLPSATDASHLMSRPDREVNHLILCCHGIGQKMGERVETVSFVKDISNFRKTLKKTFNSSPDLQAVYPKLKGGGNGVQCLPLLWRQDIRFGMARDLDSSFADDDDDDDESLNMSRDLALDDLEDDSIPTLDNINIPTVTGLRNIISDVLLDVLLYCQPNYRDKILAAVVKRLNRLYNLYKKNVPSFNGHVSLLGHSLGALILFDIIRYQGNIKYSKLQLDFPVANFFALGSPLGLFQMLNGKKIAGPIPKTNLTRSLSYSEQSFDSGVSILSCQNFYNIFHPTDPISYRVEPLVVKQMARLKPQKISHFRPHQDLSSSGVGHKIAGGALNVLSGLRSGIANTLILKSLSYASVFNEATADSHDESQGAENIRDWHIDERMYRLNKTGRIDFMLQEGALDTSYSYVSAMNAHSEYWKNVDLAHFILTQLL
The following text describes a protein:
Function:
Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Associated with chromatin.
Sequence:
MATPLGWSQGGSGSVCLAFDQLRDVIESQEELIHQLRNVMVLQDENFVSKEEFHEIEKKLVEEKAAHAKTKALLAKEEEKLQFALGEVEVLSKQLEKEKMAFEKALSSVKSRVLQESSKKDQLITKCNEIESHIIKQEDILNGKENEIKELQQVISQQKQNFRNHISDFRIQKQQETYMAQVLDQKRKKATGMRRARSRQCSREK
The following text describes a protein:
Function:
Catalyzes the decarboxylation of citryl-L-2,3-diaminopropionic acid to citryl-diaminoethane, the second step in staphyloferrin B biosynthesis.
Sequence:
MRIVQPVIEQLKAQSHPVCHYIYDLVGLEHHLQHITSSLPSNCQMYYAMKANSERKILDTISQYVEGFEVASQGEIAKGLAFKPANHIIFGGPGKTDEELRYAVSEGVQRIHVESMHELQRLNAILEDEDKTQHILLRVNLAGPFPNATLHMAGRPTQFGISEDEVDDVIEAALAMPKIHLDGFHFHSISNNLDSNLHVDVVKLYFKKAKAWSEKHRFPLKHINLGGGIGVNYADLTNQFEWDNFVERFKTLIVEQEMEDVTLNFECGRFIVAHIGYYVTEVLDIKKVHGAWYAILRGGTQQFRLPVSWQHNHPFDIYRYKDNPYSFEKVSISRQDTTLVGQLCTPKDVFAREVQIDAISTGDVIVFKYAGAYGWSISHHDFLSHPHPEFIYLTQTKEDE
The following text describes a protein:
Function:
Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis. May be required for the assembly of mitochondrial cytochrome c oxidase.
Subcellular Localization:
Cytoplasm, cytosol. Mitochondrion intermembrane space. Mitochondrion. Note=Partitions between mitochondria and the cytosol in a copper-dependent manner. Enriched in the cytosol when intracellular copper concentrations are elevated.
Sequence:
MSTAMNFGTKSFQPRPPDKGSFPLDHFGECKSFKEKFMRCLRDKNYENALCRNESKEYLMCRMQRQLMAPEPLEKLGFRDLMEGKPEAKDEC
The following text describes a protein:
Function:
Non-catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover. nat1 anchors ard1 and nat5 to the ribosome and may present the N termini of nascent polypeptides for acetylation (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MAKVQLSPKEITLFRTALKCYETKQYKKGLKAIEPLLERHPEHGESLAIKGILLHSLGNTKEGYDNVRLGLRNDVGSGVCWHIFGLISRADKDYVQAAKCYINAHKLEKNNSSLLRDLALLQSQLRQYKALADTRNALLQDNPGVRANWSALAVAQFLRGEYASAYKIVDAFESTINQGVPVDTQEESEAMLFMNLVILKKDGVEDAYKHLLSIEKKVLDRVAFLETRAEYELYLSKMEEAKSTIYLLLDRNPDNHQYYYNLQRAYGYEDASGKVLDSAEWLNLYSQLAKRYPKSECPTRLPLEKLEGDEFLTHVDLYLRKKLKRGIPSVFVDVKSLYKDTKKCKVVEDLVSKYASSLSTTNKFSEDDDNSQIEIPTTLLWTYYFLAQHFDHVGELEKAEKYVDLAIDHTPTLVELFMTKARISKHKGELQTAMEIMDHARKLDLQDRFINGKCAKYMLRNDENELAAKTVSLFTRNEAVGGAVGDLADMQCLWYMLEDGKSFARQKKFALALKRFSTVFKIFDTWADDQFDFHFFAFRKGSLRTYLDLMSWEDSVYDDPSFREAAQGSIEIYFALFDLPFAKYSPKLPDFEKLSSGEINEEEEKKIYKKLKKDLSKRLERAEKLKEADKSRAKSEDGMPVKYDEDPLGENLVATSEPLKEAQKCLEKLLPYGDKNPSAYILAAQLYTRLKNFDTASKYLEQAKVILGQNDPTVISTEKFYNSIKTQSN
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSQYAVELCEVVIQEFFGECCATVCHALLNHGRMTLQTLRSRTKLPLKKLRQALVSLMRHHLVLYAKVIEHLREVTHYEAQWTEIYNFVRKGKAVYIISQRVSQEAGSIAKYIATQGRVRVSDIFKAFGKDPDAVDDETNKLRNEIYALMEKKFLDVVQPRHLIPMFDQEMELRLKHTERLKSENMSDAKRNHEIQDAIQLDLAKLDAAEQSKEVGMKRKPIESFARPSKRRRRAGAADETADGDDFVLVPDPDALLAERRIGKTTSIVYSHVLSLLETKTAGIPMPNQHFFFTTMELSRHFKDDIDLVSCIVKDSSLKTLSVSNPVLIGEDDEDDEDEDEDVDMDAEAADESKRDRKAAALLQHLELLADSSLRFLTKTGTRAMGEWMVDYTYLSTVLREIHYENIIEQKLGDQAKTLLRIIKDKGKIAEQQLSNLALLRQKDIRAHLTSMCEVGALDIQEVPRSADRAPSKTFYLWFHRTDRAYSLLLDQLFKSMVRVLRRLRSERDQRSLLLQKVERSNVQGNEEKYLQKFELADLKKLGLVEQQLLVQLARLDELVMLFGDF
The following text describes a protein:
Function:
Shows esterase activity, with a preference for short- and medium-chain fatty acids. Also has weak lipase activity, but does not exhibit cutinase activity. Hydrolyzes various p-nitrophenol-linked aliphatic esters, including pNP-butyrate (C4), pNP-valerate (C5), pNP-hexanoate (C6), pNP-octanoate (C8) and pNP-decanoate (C10). Can use pNP-laurate (C12) and pNP-myristate (C14), with lower efficiency. Can also hydrolyze monocaprylin and triolein, with a slow turnover; Induces a strong delayed-type hypersensitivity (DTH) response in animal model of tuberculosis, cellular and humoral immune responses. Induces interferon-gamma (IFN-gamma) release in animal models and in human TB patients. Also induces IL-12 responses in mouse model.
Miscellaneous:
MISCELLANEOUS: Circulating B cells able to spontaneously generate specific antibodies directed against Culp1 are detected during active tuberculosis and in some latent-tuberculosis cases.
Subcellular Localization:
Secreted.
Sequence:
MTPRSLVRIVGVVVATTLALVSAPAGGRAAHADPCSDIAVVFARGTHQASGLGDVGEAFVDSLTSQVGGRSIGVYAVNYPASDDYRASASNGSDDASAHIQRTVASCPNTRIVLGGYSQGATVIDLSTSAMPPAVADHVAAVALFGEPSSGFSSMLWGGGSLPTIGPLYSSKTINLCAPDDPICTGGGNIMAHVSYVQSGMTSQAATFAANRLDHAG
The following text describes a protein:
Function:
Plays an essential role during the asexual blood stage development by controlling the kinetics of merozoite egress from host erythrocytes (By similarity). Specifically, prevents premature rupture of the parasitophorous vacuole and host erythrocyte membranes (By similarity); [p47]: May prevent merozoite phagocytosis by host monocytes via interaction with host VTN at the merozoite surface. Plays a role in parasite growth; [p50]: Protease activity is controversial.
Subcellular Localization:
[Serine-repeat antigen protein 5]: Parasitophorous vacuole. Note=Secreted in large amount into the parasitophorous vacuole; [p18]: Secreted. Note=Secreted during merozoite egress from erythrocytes; [p25n]: Secreted. Note=Secreted during merozoite egress from erythrocytes; [p25c]: Secreted. Note=Secreted during merozoite egress from erythrocytes; [p47]: Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Secreted during merozoite egress from erythrocytes. Colocalizes at the merozoite surface with human VTN (By similarity); [p50]: Secreted. Note=Secreted during merozoite egress from erythrocytes; [p56]: Secreted. Note=Secreted during egress from host erythrocytes.
Sequence:
MKSYISLFFILCVIFNKNVIKCTGESQTGNTGGGQAGNTVGDQAGSTGGSPQGSTGASQPGSSEPSNPVSSGHSVSTVSVSQTSTSSEKQDTIQVKSALLKDYMGLKVTGPCNENFIMFLVPHIYIDVDTEDTNIELRTTLKETNNAISFESNSGSLEKKKYVKLPSNGTTGEQGSSTGTVRGDTEPISDSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSESLPANGPDSPTVKPPRNLQNICETGKNFKLVVYIKENTLIIKWKVYGETKDTTENNKVDVRKYLINEKETPFTSILIHAYKEHNGTNLIESKNYALGSDIPEKCDTLASNCFLSGNFNIEKCFQCALLVEKENKNDVCYKYLSEDIVSNFKEIKAETEDDDEDDYTEYKLTESIDNILVKMFKTNENNDKSELIKLEEVDDSLKLELMNYCSLLKDVDTTGTLDNYGMGNEMDIFNNLKRLLIYHSEENINTLKNKFRNAAVCLKNVDDWIVNKRGLVLPELNYDLEYFNEHLYNDKNSPEDKDNKGKGVVHVDTTLEKEDTLSYDNSDNMFCNKEYCNRLKDENNCISNLQVEDQGNCDTSWIFASKYHLETIRCMKGYEPTKISALYVANCYKGEHKDRCDEGSSPMEFLQIIEDYGFLPAESNYPYNYVKVGEQCPKVEDHWMNLWDNGKILHNKNEPNSLDGKGYTAYESERFHDNMDAFVKIIKTEVMNKGSVIAYIKAENVMGYEFSGKKVQNLCGDDTADHAVNIVGYGNYVNSEGEKKSYWIVRNSWGPYWGDEGYFKVDMYGPTHCHFNFIHSVVIFNVDLPMNNKTTKKESKIYDYYLKASPEFYHNLYFKNFNVGKKNLFSEKEDNENNKKLGNNYIIFGQDTAGSGQSGKESNTALESAGTSNEVSERVHVYHILKHIKDGKIRMGMRKYIDTQDVNKKHSCTRSYAFNPENYEKCVNLCNVNWKTCEEKTSPGLCLSKLDTNNECYFCYV
The following text describes a protein:
Function:
Required during maturation of the 40S ribosomal subunit in the nucleolus.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAAHRPGPLKQQNKAHKGGRHRGRGSAQRDGKGRLALKTLSKKVRKELSRVDQRHRASQLRKQKKEAVLAEKRQLGSKDGPPHQVLVVPLHSRISLPEAMQLLQDRDTGTVHLNELGNTQNFMLLCPRLKHRWFFTSARPGDLHVVLDMAKVADTILFLLDPLEGWDSTGDYCLSCLFAQGLPTYTLAVQGISGLPLKKQIDARKKLSKAVEKRFPHDKLLLLDTQQEAGMLLRQLANQKQQHLAFRDRRAYLFAHAVDFVPSEENNLVGTLKISGYVRGQTLNVNRLLHIVGYGDFQMKQIDAPRDPFPLNPRGIKPQKDPDMAMEICATDAVDDMEEGLKVLMKADPGRQESLQAEVIPDPMEGEQTWPTEEELSEAKDFLKESSKVVKKVPKGTSSYQAEWILDGGSQSGGEGDEYEYDDMEHEDFMEEESQDESSEEEEEYETMTTGESVHDDLYDKKVDEEAEAKMLEKYKQERLEEMFPDEVDTPRDVAARIRFQKYRGLKSFRTSPWDPKENLPQDYARIFQFQNFTNTRKSIFKEIEEKEVEGAEVGWYVTLHVSEVPVSVVECFRQGTPLIAFSLLPHEQKMSVLNMVVRRDPGNTEPVKAKEELIFHCGFRRFRASPLFSQHTAADKHKLQRFLTADTALVATVYAPITFPPASVLLFKQKSNGMHSLIATGHLMSVDPDRMVIKRVVLSGHPFKIFTKMAVVRYMFFNREDVLWFKPVELRTKWGRRGHIKEPLGTHGHMKCSFDGKLKSQDTVLMNLYKRVFPKWTYDPYVPEPVPWLKSEISSTVPQGGME
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSLNRQEATRHDGSDGVDKSALSKISQLEAPTSTQETYPRSSLLHGARVAVAEPVTAAFLAGGVAGAVSRTIVSPLERLKILLQIQSVGREEYKLSIWQALKKIGREEGWRGFLRGNGTNCIRIIPYSAVQFGSYNFYKRFAEPSPDADLTPIRRLICGGAAGITSVIVTYPLDLVRTRLSIQSASFAALKRDSAGEKLPGMFTTMVLVYKNEGGFLALYRGIIPTVAGVAPYVGLNFMTYESVRKYLTPEGDSTPSALRKLLAGAISGAVAQTCTYPFDVLRRRFQINTMSNMGYQYASIFDAVKVIVAEEGVRGLFKGIAPNLLKVAPSMASSWLSFELTRDFLLSFDER
The following text describes a protein:
Function:
Cleaves internal linkages in 1,3-beta-glucan. Promotes the release of spores from asci by degrading the ascus wall; Independent of its glucanase activity; required to establish bipolar cell growth by promoting localization of the scaffold protein scd2 to cell poles and thereby the activation of cdc42. Together with lsb1, plays a role in coupling the endocytic coat to the actin cytoskeleton.
Subcellular Localization:
Ascus epiplasm. Cytoplasm. Note=Localizes to mobile dots in the cytoplasm.
Sequence:
MDVLVPIYTGPINPVFPSRAHPSPPLGLTSNLFPIQTNKFYGNLYIGTRHNPSWSHPYSVTWLNGSSYYGLAISHIDDSQRVFGPDPESVPCQYYFNPAGLYSIIISAREFASGNLLSLDQSRHFSIQATLSATTSGSGTIILPIVAGMGFVSGYYTNLTPVFNSSILFSSITKINFSRGYKYRIQLTDGKIWFLYAFPTSSSSTFNLTLASNSQLTTSTKFTGLIQICKVPNESVNNSYPDTIYDASAGVYTTSISLSAQVSGTTGEYWFRFATAGYTNLNPLMFALPHHMQSFGSDTQAYKTGLGLASTTMGIMFAYATKTWHLIEKNLPTQVGFLPIPWNGGSNTYSPTALAAIRAACATDINFDVVNASNLDSMYTSGKIVAMYAQVCLVASRILGDSTLTNTGLTKLKQAMARFTTNTQMYPLVYDTTYKGIISTAGYSSPLADYGNTYYNDHHFHWGYHIYACAVIGLLDPSWLVNDNIRYVNALLRDSANPSESDTYFAMFRNFDWFVGHSWATGIFESGDGKDEESTSEDFNFLYATKLWGMVRNDTVLINRANLMLAVLKNSLNTYIYMTPTTSVQPSQILGNYVTGITFMNKVDYATYFSAEEYCKQGIHMIPTTPISGYLRSPSYVQQDWNAKIAPIINTFSNNWTGILWSNYAIYDPKTAYNTFAASTFTADKIDNGASKTWYLAMAAGMGGSP
The following text describes a protein:
Function:
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.
Sequence:
MAEQAYTVASDSETTGEEKTSPAFPEIAIGIDIGTSQCSVAVWNGSQVELLRNTRNRKLMRSYVTFKDEVPAGGVSDELAHEHDMLSGAAIFNMKRLIGRVDTDPVVHASKNLPFLVQTLDIGVRPFIAALVNNMWRSTTPEEVLAIFLVELRAMAEVKLRRPVRNVVLTIPVSFSRFQLTRIERACAMAGLHVLRLMPEPTAVALLYAQQQQQSEQENMGSGSEKIALIFNMGAGYCDVAITATAGGVSQIKALAGSTVGGEDLLQNLMRHLLPNMKDLFSHHGIEEIKKMGMLRVATQDAIHKLSSEMTVPVDVDLGNGTKISKFLERAEFEEVNKEVFQKCETLIKRCLCDAKLEAEDVHDVIIVGGCSYIPKVRNIVMSICKREELYSGMNPLEAAVRGAALEGAVASGISDPFGSLDLLTIQATPLSIGIQADGSNFVPIIHQNTTTPVRKEQNFTTVHDNQAEALIFVYEGDEKTVEDNHLLGYFKITGIPPVPKGVPEINVCMDIDASNVLRVFAGVIIPGAKCPPPFMEVRMPTVDDGHAWSAQTLHKTYGSTLDLVTVKKKGKH
The following text describes a protein:
Function:
Probably involved in ribonucleotide reductase function.
Sequence:
MSALVYFSSSSENTHRFMQRLGLPATRIPLNERERIQVDEPYILVVPSYGGGGMAGAVPRQVIRFLNDEHNRARIRGVIASGNRNFGDAWGCAGDVIAQKCGVPWLYRFELMGTQRDIDNVRKGVNEFWQQLPRSA
The following text describes a protein:
Function:
May act as a component of the auxin efflux carrier.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MITASAFYDVFTAMVPLYVAMFLAYGSVKWWRIFTTDQCSVINRFVAIFAIPFLSLQIISSINPYQMNLKFILADTLQKLLILFVLVLWGSFSSWGSLDWVITLFSISTLPNTLIIGIPLLRAMYGVEINGLLVQIVVLQGLVWYTLLLFLFELKAKIEMGPQIPVSMGSQVGSDVSPVHAQSSVVSCKGDLEGDGEMHSKEIEDEEAPSKDSEDEGEATCSSVKMIHLFFLVLSKVIKNPNTYASVLGLVWGLIACRWNIHMPKIVQNSISILADAGLGMAMFSLGLFMASQNKIIACGKRRATLAMVVRFLLGPAVMAACSLAVGLRGKLLHVAIVQAALSQAITPFVYAKEYNVYPDILSTMVVFGMLVSLPITLAYYVLLGI