lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor.
Sequence:
MAAALLLYLPLLPGLAGAFNLDAENVIGRRGEPGSLFGFSLAMHRQLQPQEKRLLLVGAPREKAFPSQQANRTGGLYSCDITSSDTRCTRVVFDEDTDPKMESKEDQWMGVTVQSQGPGGNVVTCAHRYEKRQYVNTVQETRDIIGRCYVLSQDLTIKDDMDNGVWSFCDGRLRGHEKFGSCQQGVAATFTRDYHYIVFGAPGTYNWKGVVRAEQKNQTFYDLGIFDDGPYEVGDESRQDKNLVPVPANSYLGFSLDSGKGIVSQDEMTFVSGAPRANHSGAVVLLKKEKNQRALSLEHMFEGEGLASSFGYDVAVVDLNSDGWQDIVVGAPQYFDRSGDIGGAVYIYINQRGKWEGIKPIRLNGTADSMFGLAVENVGDINQDGYPDIAVGAPYDGFGKVYIYHGSKNGINTEPAQILDGEKTGTNFFGYSIAGNMDLDKNSYPDIAVGSLSDSVSVFRSRPVISITKSITVQPDKLDLKKKNPEDPSEIWMDVKACFQYTANPRNLNPRIKINYTFEAENERRQLGLPSRVRFKDYLSDQFTASTTLIGQNSKRCVTAKLVLQEKIKDKLRPIPIAVSVNIAGLESGSSSTRKERALPDLIPILNSNESETKITKVEFLKEGCGEDNECHSNLKLQYRFCTREGNEDRFTYLPIENGIPVLVLKDQKDIALEITVTNNPSDARNPQKDGEDAYEAKLIATFPDSLTYSAFREMRGYPEKQLTCGANQNGSQAECELGNPFKRNSNVTFYLILSTTKVNVDTTDLDINLKLETTSTQVNSTAITASAKVVLELLLSLTGVAKPSQVYFGGNIVGESAMKSEDNIGNLIEYEFRVTNLGRPLKTFGTASLDIQWPKEISNGKWLLYLMKIESKGLEKVSCQPQNEINVLHVAESHNSRRKREIAEKQLTDSKTFSLFSERKYKTLDCKVNAQCVDIRCPLKGFDSKASILLRSRLWNSTFLEEFSKMNYLDILVRASISVPAAAKNVKLTNEAAQVRVTVFPAKPVALYTGVPWWIIAVAIFAGVLMLALLVFLLWKCGFFKRSKKDHYDATYHKAEIHAQPSDKERLTSDA
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
NFRFMDKKLSLKLNGGRHVQGILRGFDPFMNLVIDECVEMAPGGQQNNIGMVVSTGRLKLQ
The following text describes a protein:
Function:
Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.
Subcellular Localization:
Apical cell membrane; Lipid-anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI-anchor. Cell projection, cilium membrane. Secreted.
Sequence:
MTQLFYLTLLLVAFQHWSSVADNFTERDNCSQCHIHASCVETNQSVTCICLDGFTGDGLICSDVDECAFQGGHNCKNSNCVNTVGSYHCSCPSGFRLTPENGCEDIDECRDPDLGCHPLASCTNSPGNYSCECLPGYAGDGHECQCFPGSCGPGLDCIADSDGTQICMDPCQKYTLLDEYWRSTSYRAGFYCDAVPRGWYRFVGRGGVRIPETCVPIHRCNTAAPMWLNGSHPSSDEGIVDGTACAHWSGDCCLWQSMVQVKACVGGYYVYNLTTPPECNLAYCTDPSSVEGTCNACGLDEDCKAVNGNWTCQCKQSSEITDIANLKPDLYCEATYIKVSLNKCLLKNLGFEEIYTYLKDSSCSGFEEKDNQSWVSVVTPARDGPCGTRLMKNQTHAIYSNTLYLSDKIIIRDTKINVNFQCAYPLDMEVSLQTATQPIISSLNISVGGTGIFTVRMALFSSPTYTLPYEGSSVALSTEAILYVGTILERGDSTQFVLLMKNCYATPSSNATDPLKYFIIRDSCPHIQDPTIQVEENGMSSQGRFSVQMFRFAGNHDLVYLHCEVSLCDSRNEKCKPTCSGTRHRSGDAINPDQVLNLGPITRRDAQTGVLSGISSHAGFLTPWLGLSMPIFMLLASE
The following text describes a protein:
Function:
Essential protein required during embryogenesis and all plant development stages, probably through a chromatin-mediated regulation of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEAAVIDAGSKLLKAGTAVPDQAPPIIIPTQMKQMLEDGSSGDNSFEDVNVDPVVRGFIRDWDAMEDLMQYVLYTGLEWEEGNEGQILFTDPLCTPKSVREQLVQLMFETFNVSGFYASEQAVLSLYAIGRISGCTVDIGHGKIDIAPVIEGAVQHIASRRYEIGGIDLTKLLVQELGKSNPSVNLNVSDVEIIKEKYSCCAEDEVAYEKIQQSSETEEHTLPDGQVIQIGRERYTVGEALFQPSILGLEAHGIVEQLVRTISTVSSENQRQLLENTVLCGGITSMPGFEDRFQKEANLCSSAIRPSLVKPPEYMPAELTQYSAWVGGAILAKVVFPQNQHVTKSDYDEAGPSVVHRKCF
The following text describes a protein:
Function:
Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.
Subcellular Localization:
Cytoplasm.
Sequence:
SMDSEGVQALIRNKEDDFKIVLNTLYKIARNILQNPLEEKFRSIKIVSKAFQEKILPFDGAIQCLLEMGFKEDGDRFTLFSETKLDDLEEIYKQLMNAEKVTLKKNLSPSLKKSQEEILPRCVNVWRFYCKKVPFYWCKLHIGFCSSLISFRLKSHLRHTAMYENKSLQQKARAVIPIVELNTRTEKRLREETNQDFSEFSNYQYCFLLELLHWFKYEFFTWTNQPPCTSCPESEKYSIGMLPPSDEDLLWGASRVEGYTCSNCNKILRFPRYNHPEKLLETRTGRCGEWANCFTLICKSMAYDARHVLDWTDHVWTEVFIVSMDRWLHCDSCENVCDKPLMYEQGWNKKLSLIVAADHEHIVDVTRRYTRDVNAVEIRRNKMFDSDWLKSTIRELNETTRLSMTQARKEKLRNRQLNEEKELSSVKTETGGEYEGRTSGSLAWRLARGETDKVKDGKSKMETCEVIRPSEDEIKSGMLTLEYSSSLDKYTRITDNNKSYDGWKSLVYCHQDVMKKVEQDWKQTYICRKEDTSVGYISWRVELPNTCLLTHVELCVKDSVFEQGHVSWLLTTDKTTHIVKSGKKNNTRTPYFNNNQFKLVHAFLRGENWQHAQLFREPLNTSEISFNVKVLWKQK
The following text describes a protein:
Function:
Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. Important in nervous system development.
Miscellaneous:
MISCELLANEOUS: The N-terminal first 36 amino acid residues are susceptible to proteolytic cleavage, leading to loss of activity.
Sequence:
MSSSAASPLFAPGEDCGPAWRAAPAAYDTSDTHLQILGKPVMERWETPYMHSLAAAAASRGGRVLEVGFGMAIAASRVQQAPIKEHWIIECNDGVFQRLQNWALKQPHKVVPLKGLWEEEAPTLPDGHFDGILYDTYPLSEETWHTHQFNFIKTHAFRLLKPGGILTYCNLTSWGELMKSKYTDITAMFEETQVPALLEAGFQRENICTEVMALVPPADCRYYAFPQMITPLVTKH
The following text describes a protein:
Function:
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.
Subcellular Localization:
Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cytoplasm.
Sequence:
MSAKVRLKKLEQLLLDGPWRQEGALSVETLLDVLLCLYAECGQAALRRDKYVADFLHWAKPFTQLVKEMQLHRDDFEIIKVIGRGAFGEVAVVKMKSTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITTLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIHSIHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKAHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNPEMVPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSITQSNAVTKDADVQRDLENSLQIEAYERRIRRLEQEKLELSRKLQESTQTVQSLHSSTRAAGNTNRDKEIKKLNEEVERLKNKIADSNRLERQLEDAVTLRQEHEDSTHRLKGLEKQYRVLRQEKEDFHKQLVETSERLKSQTKELKDAHQQRKLAMQEFSELNDRMADLRSQKQKISRQLRDKEEEVEVVMQKIDSMRQEIRKSEKARKELESQLEDAVAEASKERKLREHSESFSKQLENELEVLKVIKQGGRGLSATLEHQQEISKIKSELEKKVLFYEEELVRREACHVLEVKNVKKEVHDSESLQLALQKEIMMLKDKLEKSKRERHSEMEEAVGTIKDKYERERTMLFEENKKLTTETERLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELESLRSCSLGSRTLDPLWKVRRSQKLDMSARLELQSALDAEIRAKQLVQEELRKVKDTNLSFESKLRESEAKNRELLEEMENLKKKMEEKFRTDAGLKLPDFQDSIFEYFNTSPLAHDLTFRTSSTSEQETPGPRPEVSPSTSVSLSAEQQEVRQLPKAHQFSIKSFSSPTQCSHCTSLMVGLVRQGYACEVCSFACHVSCKESAPQVCPIPPEQAKRPLGVDVQRGIGTAYKGYVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPGVVASQVLDLRDEDFSVSSVLASDVIHATRRDIPCIFRVTTSLLGSPSKTSSLLILTENENEKRKWVGILEGLQSILQKNRLKNQVVHIPQEAYDSTLPLIKTIVTAAIIDRDRIAVGTEEGLYVIEVTRDVIVRAADCKKVYQIELAPREKIIILACGRNHQVHLYPWSSFDGSEGNFDIKLPETKGCQFIITATPKKSASTCLFVAVKRLVLCYEIHRTKPFHKKFTEILTPGNVQWMAVFKDKLCVGHPSGFSLLNIQGDGQSLNLVNPNDPSLMFLSQQSFDALCAVELSNEEYLLCFSHMGLYVDSQGRRSRMQELMWPATPVACSCNSSYVTVYSEYGVDVFDVNSMEWVQTIGLRRIRPLNVEGTLNLLNCEPTRLIYFKNKFSGAVLSVPETSDNSKKQMLRTRSKRRFVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLTGPPPTNLSRQPPSRNKTYISWPSSGPGDLGVAMPLRSMSDPDQDGDREVKRGLPRSPSTTLAATSITKIHESREIQKLQF
The following text describes a protein:
Function:
Involved in the biosynthesis of citrulline (By similarity). Essential gene that modulates defense response to pathogenic bacteria, conferring susceptibility and repressing salicylic acid (SA) accumulation.
Subcellular Localization:
Plastid, chloroplast. Mitochondrion.
Sequence:
MASLSQITLPRAPSSEIGLLRRRLERPIIRTRIGFNGRIASVLTNAGDQAVSVKASVSQKVIEEEAKVIVGTYARAPVVLSSGKGCKLFDPEGKEYLDCASGIAVNALGHGDPDWLRAVTEQAGVLAHVSNVYYTIPQIELAKRLVASSFADRVFFCNSGTEANEAAIKFSRKFQRFTHPEDKEVATGFIAFTNSFHGRTLGALALTSKEQYRTPFEPIMPGVTFLEYGNIQAATDLIRSGKIAAVFVEPIQGEGGIYSATKEFLQSLRSACDAAGSLLVFDEVQCGLGRTGLMWAYEAFGVTPDIMTVAKPLAGGLPIGAVLVTEKVAETINYGDHGSTFAGSPLVCSAAIAVMDKVSKPSFLSSVSNKGRYFRDLLVKKLGGNSHVKEVRGEGLIIGVELDVPASSLVDACRDSGLLILTAGKGNVVRIVPPLVISEEEIERAVEIMSQNLTALD
The following text describes a protein:
Function:
Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MDVKSGYQSCSGSLPSFNRMSGYWCPSLAQKPVHAFCFLLLFLRCPSRSHQNVTSNHTLTLAVVLPESNIRYAWSWPRVAPALRMAVDRAQELQLLSGYQVKWVFLTSELNGACSEYVAPLNAVDLKLYHNPDVLFGPGCVYPSASVARFATHWRLPLITAGALAFGFKQDDDHYNTTVRTGPTAIKLGEFVSHLHEHFNWSSRAALVYHDVKMDDRPHYFIIEGVFLALDKEFNNLTVSYQMYPENEDIGSVIQFIQNNGRVIYICGPLEMLHMIILQAHREKLTDGDYVFFYVDVFGESLRPDGTREANKPWQGNHSQELKEAFKTVLVISYHQPENPEYFEFQKKLIQKSKEEFGVELNYSLMNFIAGCFHDGVLLYAQALNETLREGGSQKDGLSIVKKIQDRQMEGITGTVSMDKNNDRNTDFDLWAMTDHEEGNFEVVGHYNGITKQINWTGKPILWLKGSPPSDSPPCVFNADDPSCLKTTVSTLAIVALGAGLTLLIFGMSSFLILRKLMLEKELASMLWRIRWEELQFGNSERYHKTAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLGSFQSSCETDDGYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYILGMDLSPKEIVQKVRNGQRPYFRPTVDISCHSEELGILMERCWAEEPLDRPDFNQIKAYICKFNKEGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLETVKTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSASKEVLDEFSCFQLELRGDIEMKGKGKVRTYWLHGEHREDDVI
The following text describes a protein:
Function:
May play a role in muscle cell metabolism.
Sequence:
MVIEEWKKSGIATKFPTYRNSALITTHSWQKGKRQDDGAEGLWRINDGIYDFTSFIDKHPGGPFWIRETKGTDITEAFEAHHLTTAPEKMIAKYKVRDAAEPRIYTLTLEEGGFYKTLKERVREQLKTIDKRPKKKSDLIHLGLVVSLYLLGIASAKYNSLLALVLASVALCWTVIVSHNYFHRRDNWQMYAFNLGMMNFAAWRVSHALSHHIYPNSYFDLELSMFEPLLCWVPNPHIKSKLMRYVSWVTEPVAYALAFFIQMGTRIFYSLRHTNILYWHDLLPLTIPIAIYLGTGGSLGIWICVRQWLAMTSIASFSFCLIGLNAAHHDPEIYHEGDANREDRDWGLFQVDTIIDRGDLKWSQFLVLTHFGDHVLHHLFPTLDHGLLPALYPVLYQTLDEFKGHLRECNHIEHMIGQHKQLLRIEPNPRAPGAGK
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Subcellular Localization:
Nucleus.
Sequence:
MEVAVAKALKPSLRSEFIVQKMHCEDIFSLNANTVAVGEDFSVDDLFDFSNGSLHNEHQQECDEEKQSLSASSQSQDRGEDDSNSNSTGVSYDSLFSTELAVPAGDLEDLEWVSHFVDDSLPELSLLYPVRSEEANRFVEPEPSVKKTPRFPWEMKITSKARSVRNRKPNTRVWSLGSTLLSLPSSPPAKKQKKRAEAQVQPVGVQIQRRCSHCQVQKTPQWRTGPLGAKTLCNACGVRYKSGRLFSEYRPACSPTFCSDIHSNSHRKVLEIRKRKEVAEPDTGLAQTQMVPTC
The following text describes a protein:
Function:
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Subcellular Localization:
Chromosome.
Sequence:
MEKERASHVADERLIFTQSSNVHQSENLITKLHNGNQLQEVPPQQTNGDSNWNHFKPNMGINQMKMYQENCSSPPVKQELLEQSQHIKNGGIKHAFSESSLLELCQSKKPRMDSEINGQGSQIAKNNVISSWSKNESAEMERKLGSFPEPLKPSECRDVPQCPDTQKELNLNKENCNYSNGDIFSLSRDKKVPISNGAMVTSSSMEDMPDYLLEQTLSQYNPAHVSITSQNNESQDNAIKSPAESNLEEQARNSPSHVSGLPISPQIPVSVQLDTISPEIHTKSIYSPRFGTDGYSGAFQGKHQKQPQQESYSLQDVPGKDEQHLQSQEGQVPSIVLPARPDGSLQDQIHVECFSDNVETSDTYVKSNKDFSQEPYLSRMEPKFPLEEGETDRLIHFNDKAMERTLKSKESETRQQELLFESQKHFDHPTAGGTSQSPAPELINIHHVSANSPQPQPSYKPQQDQKALRHLLAHQAPSSNLEHKRAFKEEAGEMLQQTNSYAETTWIDLNSSQPPQQGDLSRLWKDFNLRQQQQMSNQSQEKILDSDNMQGFQIQGFSHSSMQQQQKQLSDVYKPNVEQDQAQRTDTAEWQQMNSNTPPGVQQVEPQMQPNKLQHQSSQSSLSQQQVQHPFQPKMLQEGECNSTQEIKQKYLSNFLQQQQQQPPQDRTEEHQVLNTLQQHPSQDTSSIGTGQPKDSWKLEEFIRLEKGLKSSDCKSQPPQVQQQTATLSPSTNTPGFLDSSSPSAQPQQNDSSHFTYGKTNNTVMHRHCKFSNAMEIQQSQYCPNPAAPKQYVEQQRIREQSNHRNVSQLPPPSTQRQPQQGALNQHILGLMTAQMYPKTESQDSCAQAQQGQNQNHPGDLQKHAILRMHLLQKQEKQAYQQNLEDFRHLLQSIKKENHPMSEPPVPQTARDLTNSAVNNMIKQEYSQMDCDQSRQKSIIATMEHQLKQYHPSPLFERKSLVIKSPKQVKVETSGPVTILSTNADLGNGDIGAASLKKKDCTPTKKTEANLNSFIESPMKLLDTPIKNLLDTPFKTQYEFPSCHCVEQLCEKDEGPYYTHLGAAPNVAGIREIMEKRFGQTGKAIRIEKVVYTGKEGKSTQGCPIAKWVIRRSGVEEKLLVLVRERAGHSCSTATIVVLILIWEGISPTLADRLYSELSQTLKKHGALTNRRCALNEERTCACQGWDSETSGASFSFGCSWSMYYNGCKFARSKVPRKFKLLGDDPKEEERLEQNLQNLATLMAPAYKKMAPEAYGNQVEYEHRALDCRLGLKEGRPFSGVTACLDFCAHAHRDLHNMQSGSTLVCTLTKEDNREIGKIPEDEQLHVLPLYKISSTDEFGSEEAQREKMKTCAIQVLSSFRRQVRMLPEPAKTCRQKKMEARKAAANKPSNPETPNSKTERNLQARVKQSTFESNGQNMSMSGRISTPHLKITKNSLRSKSQSHIGSSHLGPQQNSLSSHQQKNNLNHHPNSLHPHSFQRFPNPTDQFPSTSQPANLYQESTTPTNPYPTSLRAADSYLNASTPMNSYPASLNPSNLHTAYQCNGSMPVDNCNPYFASDPKHIDLYRHQTPETMSKIGLSQLYSQQQYNPHQHYGLNYSPQYGDHNIQVNGYGNCNMRPNVHSMGPYPSFGPNAGTEAQFFEAISRPPSTRPNLDYAAVNKGNQYNRYPNPYLVQNSSVFSSVHDSFHMQHKTEVNLHGPNGIARVLPTLGNECPNLSQLGYGLTNGNFQGNLSEPEPGAQNPKESNEDVWSDSEHNFLDPDIGGVAVAPSHGSILIECAKRELHATTPLKHPDRNHPTRISLVFYQHKSMNEAKHGWALWEAKMAEKAREKEEESEKQGSDNGPIRSGSKKIKREHSEVLDQSEPPYKRFIQTLTQRTVSCTTNSIVNTSPYAFTKVTGPYNRYI
The following text describes a protein:
Function:
Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Contributes to formation of the opaque state, but is not necessary for heritability of the opaque state. Plays a role in cell adhesion and pseudohyphal growth. Involved in acquisition of drug resistance and acts as a repressor of beta-glucan synthesis, thus negatively regulating cell wall integrity. Plays a role in adherence, invasion and damage to oral epithelial cells.
Subcellular Localization:
Nucleus.
Sequence:
MSSIPNINWNDPNNGKSNTSRQSQPQPQLPSNVSPPNSRAVPTSGSIGGPQYGSSQFSNEYSRNPNTIGGPPFPLQSNQRGYMPNTGYPVQQTAQQRSGDKLQQVHSQQQQQQQQPLYQQYPPQSVGYLAGDVYNPQHQEYVQMNQLPNQHYNLQQRQQAQGQQLKSQLNEQNAMMSASTQQYPVQDFTNPYPNAQNPAEQQQQQQPLRTQSQQWDGYQSQPLYSAAGNTIPSSIQQQIPPQNLSPSEQQQVKQQQPSPPEQGTKKKPGRKPKLRKLSESSSETPQVPKTASSSSSSPTAVNSGKPITKRSRMGCLTCRQRKKRCCETRPRCTECTRLRLNCTWPKPGTEHKNKPKDQKDDENTIEHAEFGRIKVLRGIVEYRSK
The following text describes a protein:
Function:
Centrosomal protein which may be required for microtubule attachment to centrosomes.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSSKILHSPNSQALILALKTLQEKIHHLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQIKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHFKEKKTSSKKTKCIKRGPPWQICSKFGALPFVAEKSTSANCSVNASMQNLLQRRQHRGPHILQKPFNVAETRCLPRPSRTTSWCKAIPRDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLVKKMEIKGEQISKLKKHQDSVRKLQQKVQNSKMSEASGIQQEDSNPKGSKNIKNSPRKCLTDTKLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MPRADWSFLESLLEEGQEYSTAIGRVWLTILFLLRMLVLGTAAESAWDDEQEDFVCNTKQPGCTSVCYDKAFPISHFRYFVLQVILVSTPTIFYFAYVAIKVKENDQKNKGKEENQADKGHSGRKTVKTVVECNDNSKSGKDKMEGDGEKCQKPKPKACSETPKLKGRLLGAYAFSILLKILLEAGFIVGLWFLYDGFFIAPKFVCTRSPCPHTVDCFVSRPTEKTIFTFYTQLIAAISLLLNLIELLHLLVLAISHRLEKRCRAQHQDFLPRFEQVPSRLRTAGLPVGASQANSTGSHISLPIQGEGEVQSDPCGSCTDMTVEMNWEPAEAGSDLLPSYANCIKPMRKPRQYRCHYKKHSPRNGQNQKSANRSPSEQKHYV
The following text describes a protein:
Function:
Crucial component in meiotic recombination, functioning at some point after the initiation step of recombination. Plays a role in promoting the crossover outcome of meiotic recombination events. Required for formation of normal meiotic crossover, and crossover and chiasmata generated by artificially made DNA breaks. Together with him-14 and zhp-3 plays a role in the activation of DNA damage-dependent apoptosis at the DNA damage checkpoint in pachytene cells.
Subcellular Localization:
Chromosome. Note=From mid-pachytene, co-localizes with cosa-1 and rmh-1 at crossover sites of early recombination intermediates. Co-localizes with brc-1 at crossover sites in mid-late pachytene nuclei.
Sequence:
MSTRWRYYNSKRGNGFRGRGRGRGRGTSLTAVALPRDDNFHKGAQDGAYFKDMPMDPEQFRDETVLSLSFAQGMLGAAYYEQSSQLLKIMNDISEDLEFRFLKRLIDDVKPTLIIANRSQDLEFIKFLTTRYDPQEKIYEDGTTEEGTSEDTVPTWDSSLAYSTDETTAEKEEKEEDEDDDDEGLPAKLNKLPNNFFRMSRAIERLKAMAGSHDSSMTEEDKYIIIKMRFDIEAVNMIRSFGALLLFLDETRMGVTDDPLSVTSPIKSIKTFTLGNLVEIDFNTIQALDILPKETENKKTFGQGRSLYQLMDKCRSTVGKKCLRKWFRNPTTDRDDLVSRQKCVHYFKQDWNAEVTAKLSSILGRVKALNSVFQKFQSGTAQLIHWECFVSTVNALVEILNIIRQTPISKEFPVESDLLREVSEIAVIAGSIINFAESKIQGRVTVMNGIDEELDEIRDTYENMPMVLTAIAKQEEARLGLPPYSNVACVYIPLVGFVLSVPRDYGVESQPDMTLLYSTHEDLRVRNATTSRLDDEFGDILMRLIDSQTAIILTLKTRVMKKKRSIIKLLSIASRIDVLISFGLIAAQNGWNCPALVDEPVIEAVELYHPISVLVVKKSFVPNQVSSGRDGIKASIITGPNACGKSVYMKSIGIMVFLSHIGSFVPARHAKIGIVDRIVTRMFTVDSVLDGMSTFAKDVEQVALALRKATGNSLVIIDEFGKGTMTEVGLSLLASVMTYWMNRGADRCPHIFLSSHFHALPNYIPLETNIATFLTFTVLREAGGKIKYLFRMTPGLVDCSFALSVAKEEGIPPPVIGRACRIYKALKAGTLLKEIKAEVSNDNEKQLVEDMDVVLADEDGFMAAVESFVKRKKTSFCESSMRNVSEEIEKERSEASTPASKSRSTITARSNSVLSSRSMASVDQLSVLDALLPKKKKKKVTGSSMESSMSPDPFQEEDEGTEGEEDQISAPVSRPTLPSVQKYASEEEKQQSINSRHSFSTRTAIHIPTPIQMGEAGGVKRPRSTSTSSPGPSASKSVRTEVFKKTPNVKESQVLETPKQLSISSFLEPKFPSSEKDVISRVSERYLQSDPFKTPISDRRSQQSSRHSTPKNRSMNQSLIQSARDTPHETIRSSNEVNPEFFNIFNFPDDSILKSQDTYDPNVTPRSSSRRELRPDVSHSQNSQFGEVFSELGTQFSIFNSQQSFPGNSMGTTNPDCSIFDDFFANSQDGEKKIDSTKTSMPIVNSDNFIFKTPEPRSSEKQRSLLKNKGQASNSSISPSSLILGQLAFGDVDQTPRPRGDNPIEFQYDVVDDDDPIFEEKNCSAPVFEFLKSNDDEEDDEFLKSFLETEGSLHIDTSADETIDRSKRS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MQSDMELLAERIVNHAMAIIHLITGESDSADTSCPSLSKDGRRDDTLLIDRIIAHATHIIQLMASKVSASSDEIKLRFSAEMLEDQTEPTIEILDDCNNQEAEDKEDIKEHVNGQHLKSPVESFTGGTEERNNVQSTLYLPNWKIKINRLTPACRSKKLWNTPKSRRKPVRLSLSPTVEPSIYCSQNPLDSQRDELSGSPAFLNQNIKLETNLVNIRNGLHTKKYKNRQFSTVKEELVEGNNIEQIQDTYLRHMKGFVDGLTFDSNQSKQLDDRPLGMSDGESFSRISQLSRKSPGKSSSTSLHKKALDLMRPQEILHEEVPYAVTESGKSFVISSDLVKVQISHSGEKSHICSECGSGFVSSSSLLKHQIIHTGEKPYTCKDCGKSFSFNSSLIRHQRVHTGEKPYVCKECGKSFSISTTLVRHQRVHTGERPYACRDCGKRFTCNSHLVIHQRLHTGERPYTCVECGNCFSNGSDLVKHQRTHTGERPYSCSECGKCFSIISNLITHQKGHSGKGPCKKSRIKSDH
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MLQNIPHQVVQSPARLGLPNPNSPSLQNTNLPKFTSQTPQNHQQQQQQQQSNQLTTPAVSSTLLPLLPPLPRAQSLLIQMASLSSKLFEVSPNRPHWIGAFRGQLPSFLSSQPQPVGAAPQDSSPSSAKEIISQFAALQTQLFEAVAELQQILDLQDAKQKLAREIRSKDSALLAFANKLKETERVLDILVDDYSDYHRQKRTKSSEEDSSTTTIETQIKLTDILSYAHKISYTTFAPPVFGAGQAPLRGALPPAPQEEQMRASQLYNFADLDIGLPKTDEGREGIIEAVVEAEAAAPAKDLLMIPANIVVPSGWKPGMPVELPSDLPILPPPGWKPGDPITLPPLDALAGPARPDEQQLRAGPPPVLGRAPEPIQVRHVQLDIEDDSSDYSSDGGSSSESED
The following text describes a protein:
Function:
Transcriptional repressor involved in the regulation of gibberrelin (GA) signaling. Binds to the 5'-GATC-3' motif of HD16/EL1 promoter. Functions as a positive regulator of GA signaling by suppressing the expression of HD16/EL1, a negative regulator of GA signaling.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing HAZ1 show increased length of the uppermost internode and panicle, due to enhanced gibberellin signaling.
Subcellular Localization:
Nucleus.
Sequence:
MDKTTTSDLVLDNDNIGSNAGSAQEPLTTNGKTSGVRNRYKQTVKRGRKGSQISPSKTYPLRSSHSNVRVLRSASKKKNETPIVPTNDNTAVQRVAKKRKRSKPLRPAPSRVLRSTSEKKNKAHNELLNDGAGVQPAEKKRKVGRPPKGGTPKDDYLMIRKRVRYVLNRMNYEQSLIQAYASEGWKGQSLEKIRPEKELERAKVEILRCKSRIREAFRNLDSLLSEGKLDESMFDSAGEISSEDIFCAACGSKDVTLKNDIILCDGICDRGFHQYCLNPPLLAEDIPQGDEGWLCPACDCKIDCIDVLNELQGVKLSIHDSWEKVFPEAASFLNGSKQIDASDLPSDDSADNDYDPTLAQGHKVDEEKSSGEDGGEGLDSDDSSSEDSESSEKEKSKTSQNGRTVDDLGLPSEDSEDGDFDPAGPDSDKEQNDESNSDQSDESDFTSDSDDFCAEIAKSCGQDEISGPSSSQIRTVDRTDGSGFDGEPNAENSNLAFMETELEQDMVLPISSKRQVERLDYKKLYNEAYGKASSDSSDDEEWYGNSTPEKGNLEDSETDSLAESPQGGKGFSRRAPVRYHNNEHTPQNVRPGGSVSDQQTEVLCSNSNGSTAKNRHFGPAINQKLKAHFKEDPYPSRATKENLAQELGLTFNQVTKWFSSTRHYARVAATKKENNIENHTAENNNNTNTVDSIQLRGSNDIVSVDRNDMVSEERTGQSNLNEGTPLRSDTSCGQSVAVTPMVHPENQGNDSSSNVRTPNAKSAEKLIPGLENSDEARRKAVQRELRKMKTGR
The following text describes a protein:
Function:
May have a role in the recovery or adaptation response of photoreceptors. May have a role in diverse sensory neurons and in development.
Sequence:
MGCGTSSKKGNKSKKVIKAALVIQNWYRRYRARLRVRQHYALAIFQSIEYSDEQGQMQLSSFFSFMLENYTKTNNEDSALVTRIFDNTRRESQIKDRDDFLGLIEVPDSYDGPRLQFPLTFTDIHILLQAFKQQQILHAHYVLEVLFEARKVLKQMPNFSHVKTFPAKEITICGDLHGKLDDLMLIFYKNGLPSENNPYVFNGDFVDRGNNSMEILMILLVCFLVYPSDLHLNRGNHEDFMMNLRYGFTKEILQKYKLHGRKILQVLEEVYTWLPIGTIIDNEILVIHGGISESTDLNTLHQLQRNKMKSVLMPPVLGNQETGEKRNKSASNYVEPRKVEPDKTPSEDLTKQEWEQIVDILWSDPRGKKGCYPNTSRGGGCYFGPDVTSKVLSKNQLKMLIRSHECKPDGYEVSHDGKVITVFSASNYYEEGSNRGAYIRLSYGTMPQFFQYQVTSTSCLNPLHQRMNAMESSAFKILKEKMISRKTDLINAFELRDHSRSGRISLAEWAFSMENILGLNLPWRSLSSHLVTIDSSGSVDYMSSFDDIRIEKPTKDMKSNLTETMYRYRSDLKIIFNIIDSDQSGLISMDEFRTMWKLFNAHYKAHIDDSQIDELASIVDFNKDGNIDFNEFLKAFYVVHKYDKPGTSLA
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
Miscellaneous:
MISCELLANEOUS: Dicyclohexylcarbodiimide (DCDD) binding to the active aspartate residue inhibits ATPase in vitro.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MENLNMDLLYMAAAVMMGLAAIGAAIGIGILGGKFLEGAARQPDLIPLLRTQFFIVMGLVDAIPMIAVGLGLYVMFAVA
The following text describes a protein:
Function:
Subunit j, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain. Minor subunit required to maintain the ATP synthase population in the mitochondria.
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MLQSIIKNIWIPMKPYYTKVYQEIWIGMGLMGFIVYKIRAADKRSKALKASAPAPGHH