lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Miscellaneous:
MISCELLANEOUS: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
Subcellular Localization:
Cytoplasm.
Sequence:
MPKSALMSSSFQTSVSPRPLPVSCASRTAARKLSLYCSEGRTRCGMGQGKGWRWPGHRPPGLPSPTNRVGQSVPKWRPQPHKAAGGGRTIRDVKEAAFDVLDLGLLPYPQAWARQKQELARVAVGGRPTLLLVEHPAVLTLGRKAQEGENIVVTREYLAAQGIDVFAVERGGDVTYHGPGQLVAYAIFPVGRRVRDFLRLLENAVVTALGTLGLPDARPNPGYAGVYVDPREINGKTYDQKICSIGVAIKQNVALHGIGLNVCTNLDHFDLIVPCGLTDTQMTSVQREYDLRGLGSVSMEQAKKALTDAFALTFADYDWSLPGVAAGQEALSVASP
The following text describes a protein:
Function:
Chaperone component of an atypical, type II toxin-antitoxin chaperone (TAC) system. Prevents antitoxin HigA1 aggregation in vitro at a 1:3 chaperone:antitoxin ratio, probably also protects antitoxin HigA1 from protease. Required for neutralization of toxin HigB1 upon ectopic expression in Mycobacterium marinum or E.coli. When expressed in E.coli complements a secB deletion, restores export of OmpA and MBP and inhibits aggregation of proOmpC although it is less efficient than endogenous SecB. Complements the general chaperone function of E.coli SecB less well.
Sequence:
MTDRTDADDLDLQRVGARLAARAQIRDIRLLRTQAAVHRAPKPAQGLTYDLEFEPAVDADPATISAFVVRISCHLRIQNQAADDDVKEGDTKDETQDVATADFEFAALFDYHLQEGEDDPTEEELTAYAATTGRFALYPYIREYVYDLTGRLALPPLTLEILSRPMPVSPGAQWPATRGTP
The following text describes a protein:
Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Subcellular Localization:
Nucleus.
Sequence:
MNNIMEPASTETFSPQIHVQGFVDEAIKTLDVSDLYSKRETLRSVAYAEAMNVPIETVDELKSVCSMQTLKCPSEDIHKDAAEVPTGTELVTLGLRKRYLDSKPNINKNCKFTVLSWNQEHVYQDVKPPPEREVKPQCAVLQVAVFHPSKRNRRKSKGKRMRLAQEYRVLGYQKLTDLRDAITCIADHTIAGEFSERPCNVPDIRAKDIYKSAYFFIENVFYNDFRYEDNRDLSRNVREWEQNKHEGKGSYTTQHMEDVKFNDLHIRLGYPYLYCHQGDCEHLIIFKDLRMFHADDCRDEGLYPLMVNRYRFRRQMCRVCATFTAKWVTYDDQLAEESPCFFCDLCFKALHYSKDQTKLAEFEAYPYVDMGIFNLAIV
The following text describes a protein:
Function:
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
Sequence:
MTDWIDGQGRQIDYLRLSVTDRCDFRCVYCMAEDMRFLPRQQVLTLEEIERVARLFVAGGVRKLRLTGGEPLVRPGIVGLCERLAALPGLRELCMTSNGSQLVRYARPLYDAGLSRLNISLDTLDPLRFRAITRNGELDKVLAGIDAAQAAGFRRIKLNAVVMKGRNADEVPALVDFAIARGLDISFIEEMPLGQVGRERGESFCSSDEVRALIAQRHALLDSAEQSGGPARYVRLVEHPQTRIGFISPHSHNFCATCNRLRLTVEGRLLLCLGHEHSLDLRALLRRHPLHDGPLLEAIGEALQRKPARHEFSAAGEVQVLRFMNMSGG
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Sequence:
MSILVTRPHPDNEATADNLRARGHVVLLAPVLKFEPVAFHDESEANYSAIIVTSANAIRAVAPQLQDLGLLKLPLFAVGEHTATAARDAGFAEVIIAGGDSAALRDTVVRSARDKVLKKKSTLLYLAGADLSRDLGGELGTEGFNVVTQTTYRMAPVKVLPRDVCEGFAAHGIEAVLHYSRRSARAFLDAARDEGVEISALAIPQCCLSETVASVLRDAGASQVLVAAKPDENALFDTLERALQTRLA
The following text describes a protein:
Function:
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAVIRVCALLAIAGTAIVYSKYSSAVWSAAGFAIIGYLATNTLIPRVADSFIRVGLYGKDLGKPGRPVIAETMGAVAATVYLFMMFLSIPFVFYKYLVVTSGAGARDWSEEAAGRGAFPHGKLSEYLSAILSLQSTVLLGVADDLFDLRWRHKLYFPIISAIPLLVVYYADFGVTYVLVPKFVHQWVPQLSEFALIDLGWFYYIYMASMTIFCTNSINILAGINGLEVLQSIILAIVCLVNDALYLVWGSERTRESHLFSIVMLLPFLGVSYSLWKWNSWPARVFVGDTYCYFAGMIFAMIGILGHFAKTMMLFFTPQIFNFAYSIPQLLGLVPCPRHRLPRFNEEDGLMYTSRTDLQKRPPMRPVALALKLLAYLHLLDVTVDEQGNLLDCNNMTLINLCLVWFGPMREDQLCLTVCGIQLVVGLLCVFARHAVGTLLFGEDNYTRIIKYIRT
The following text describes a protein:
Function:
Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.
Subcellular Localization:
Nucleus.
Sequence:
MFSMDSFAMDKDAKLYEGNALFRNQPSYKVFNKSFEHVDDALYTLLNEVEPDVLRMELQETGDLFKSFNRNSALRDPRNNEVPPKPTRDLTTASSLYSFPNPLEQYSELNLKQQAACMRVLLAWQCSQPVDEQDIVVWQATEKKRYNEQQRVQKYIHDHEQGRKEVIYAPMKSLVAVYRKWYELGVKKLQQTYPNDSYMTFSGLPQLPQCRSLNAQTASIEQVELERIVGRVRLLPEVEVRHEALRTLRLRLDRYATRETRAPVQLLREEDKELELEAGNVFVLPLDSLLMLLTTGSYIDLPTEMFLSLRESPNSKHKCMEFQSPFPPRNCGWHTNSLILKLAYGAYISQPGQAKWLDFNINGAVKEVPDEPACDKSSIDLQMVYKPRAIDQQPSDIEDGNCNSALVSWTLRCKGEGDDCNDFQIFSTLSIPAVKDSSGKEPLGCHFIKLENKPDCGCEIMSKYELISAWVQLKLMRAEMGHCTRISLRDFEPMLEEKLTLISLEQQLHDYYNTSMPQLLSNLCEFLKLLDTVPAGDYLLRYSPKYKDKFLLCIVTKEATPQSFQLHQLLTESIPSDQAFLTQSSYLPISPTLCGRLHEELHLLPCAFPAKANGRSVQRRKVVVPIPEPSRQAPVRRQRLKKWSEAQTREFRRRCKVDQKKRARARKTAAANKEKIELEKIMTL
The following text describes a protein:
Function:
Mediates, together with protein p6, the early to late transcriptional switch by stabilizing the binding of host RNA polymerase (RNAP) to the late A3 promoter. Activates transcription from the late A3 promoter and represses the main early promoters A2b and A2c by modifying the topology of the sequences encompassing early promoters A2c and A2b and late promoter A3 in a hairpin. Proteins p6 and p4 bind cooperatively to an approximately 200 bp DNA region located between the late A3 and the early A2c promoters. Binding of p4 molecules induces the reorganization of the binding of protein p6, giving rise to the nucleoprotein complex responsible for the switch from early to late transcription.
Sequence:
MPKTQRGIYHNLKESEYVASNTDVTFFFSSELYLNKFLDGYQEYRKKFNKKIERVAVTPWNMDMLADITFYSEVEKRGFHAWLKGDNATWREVHVYALRIMTKPNTLDWSRIQKPRLRERRKSMV
The following text describes a protein:
Function:
Methylates histone H3 at 'Lys-4' (H3K4me). Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The SET domain is split between the S-sequence (residues 1-49) and the core SET domain (residues 181-258), however the two segments still come together to form a conserved SET domain fold.
Sequence:
MTIGSMENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFDSLINFVCHTCFKRQEKLHRCGQCKFAHYCDRTCQKDAWLNHKNECAAIKKYGKVPNENIRLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEHFGEEEQKELRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLHLSEERRRQLKKQYYFDCSCEHCQKGLKDDLFLAAKEDPKPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNLYVLRLLSIASEVLSYLQAYEEASHYARRMVDGYMKLYHHNNAQLGMAVMRAGLTNWHAGHIEVGHGMICKAYAILLVTHGPSHPITKDLEAMRMQTEMELRMFRQNEFMYHKMREAALNNQPMQVMAEPSNEPAPALFHKKQ
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MKSLDPDLQGETLRLTHSIINSQDEMTTSEKTNSQDQCASSEYVHDERYGRDMQAQIKPALFSSQNEVAHSTGFSPFGYSDPYMTGLYTAYGPQAFPQMMGIAPTRVPLPLDLAEDGPIYVNAKQYHGIMRRRQIRAKLEAQNKLVKNRKPYLHESRHLHAVNRVRGSGGRFLSSKKVHQSDPNSYPTNAISSQDSVERENSTSAFSSVRKDVNNGVSFQQQPDHRAFGVSSHMAITMQGNGNQQRAPVVR
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MADRSQPPPPMERTAFDTADDETSALSTAEFLTRYEVLKRRLQRVKRLKKLYKTHYWALMEELRSSYRKYYWEYGKSPYKEDDNNNNNNNKINENSNNNNNNNNAEKKDIEEGGFVKKCGMAGCKTKAMPMTRFCHLHILSDSKQKLYKGCSYVTK
The following text describes a protein:
Function:
May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).
Subcellular Localization:
Cytoplasm. Note=Concentrates at the leading edge of cells.
Sequence:
MERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKLQCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREELRARGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAPPCPVPPDLLRTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERWLQVLGELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSNDIFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESRGCQVLAAGSILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALYPLLNEAAPLALGAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRNQLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREMLKDPFVRSKLISPPTNFNHLVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMGSEGLGGDADPMKRKPWTSLSSESVSCPQGSLSPATSLMQVSERPRSLPLSPELESSP
The following text describes a protein:
Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP45 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation.
Miscellaneous:
MISCELLANEOUS: Present with 4800 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MAKDIEISASESKFILEALRQNYRLDGRSFDQFRDVEITFGKEFGDVSVKMGNTKVHCRISCQIAQPYEDRPFEGLFVISTEISPMAGSQFENGNITGEDEVLCSRIIEKSVRRSGALDVEGLCIVAGSKCWAVRADVHFLDCDGGFIDASCIAVMAGLMHFKKPDITVHGEQIIVHPVNEREPVPLGILHIPICVTFSFFNPQDTEENIKGETNSEISIIDATLKEELLRDGVLTVTLNKNREVVQVSKAGGLPMDALTLMKCCHEAYSIIEKITDQILQLLKEDSEKRNKYAAMLTSENAREI
The following text describes a protein:
Function:
Required for efficient biogenesis of the 60S ribosomal subunit.
Miscellaneous:
MISCELLANEOUS: Present with 2940 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSAGDISAINIKSVKKNRRRKKRRTADVSSSDSSSSDPSSESEKEEIQNGAIEEHVGENGKSDHVFSKGNDEDKQEDIAIEVSDVELTDEESKDLKLNSKEVIDDLTKISLSKIPEPTKSQNKEGFMNASKIAENIKLAREEYNELAENFVPKGKDKTKLREEYLNLLFENYGDDINRLRAAPDFTNKSLSILADALQEGIGMFDIGELELVLKNKEMEN
The following text describes a protein:
Function:
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
Sequence:
MNIFERIYLFFYLRKKKKDLKSQKKLPFPVISVGNLTVGGTGKTPFTIALAKELKKREYKPIILTRGYRGRLKGPLVVTEEMIARDVGDEPLMMAMEGLIVIKCPDRYSGGIYAIEKLGFTDKGRAVFIVDDGFQHWKLYRNVNILLIDGFKGFGNCCLIPCGPLRSPLTEITEADMVFITKKENNTIYQHIKDMGIKEVYFAPFKVEGIISMDGRKIEPAGQKVFAFAGIGNFQGFLTLLNGVGFKVGRYKKFIDHKKYSETTLKKILNLAAEAEVLVTTKKDFVKIKDFSNLPDSLCYMEISMEINSQTVDKIMDLMHNC
The following text describes a protein:
Function:
Catalyses the transfer of galactose onto proteins or lipids.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MNQSSSLTSSLKFSRCSKKLVTRIFFSLYVCLVMFALFNFKGRVQITYPSYMFQKTKFFCQIKEKLGPVKLNMYSNVSLLKVRMRHKDVLLGGEWKPPCRSWQKLAIVVPYRDRYHHLLQLLDRLHAMLKKQLVHYKIFVVEQSGKDKFNKGRLLNVGVVEALKDQPFDCFVFHDVDLLPEDDRNIYHCNENVHHAISALDEMRYHLLYYNNLGGVVIISKDNVFRANGHSNSYWGWGNEDDDFNARTMEIGLMLTRPPENIGRFKMVRHAKLWRESHGYELFLTWKSRWMSDGLKQLNESMYKVVSVTVNQLYTNVTVDFGPAPLQMTTPGPKDTRVSYFWFLNFYFP
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDRRDEKPADFLLPETVKSWFSHLYTHLISGNVTEMARLYDREFHNLTNNYFKQASWPEPSAVQSLVDEDPTFLLLYKQIYFRHLFSRLQPGMDMKVASWETYCAIFDGVLDGSLELEALPSQWVFDIVGEFVYQYQTYCQYRAKVATKGDAEIASYQENLFIWDSSKVLGYLHALVRHSKIVEILKEEEGVKAPSAVVKELGYFSLITLARAHVLFGDYYTSIKLLEPIDLFNKSSRGETKTTAQIHEKSPGCHVSVFYHMGFAQLMLEDFAAAIRSFSTIILQVNRNRNYYSRFADYEQLHKLTEKAMALLAIALFLCPGQRVNDQIHTLIREKYGDKQTKLQKGDISALSELFGFSCPKFILPVVAVEGEAPVNRSAEASQRQQKAFNDMVARQQHIPAVRSYIKLYRSIDLEKLAAFRGIDVELARAELMSLKVSGSRLKSDVHFYLNNNLVLIDEEASNQRTGEFFINHIHRFARIVDECAVNQ
The following text describes a protein:
Function:
Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle. Presynapse.
Sequence:
MDTSDLFTSCKKGDVCRVRYLLEQRDVEINVRDKWDSTPLYYACLCGHEELVRYLLANGAKCEVNTFDGERCLYGALSDAIRRELKEYKQITAKSMKRDYYDDFLRRLLEQGYQSDIVFIVHGKPFWAHRCVLSARSPYFAEMFETKWKGKSMIALKHPLINPAAFGSLLQYLYTGRLDIDVDYVNDCKRLAKQCQLQQLIEDLEIKCKKVYEFVASKPGTCVKVLTIEPLANCQLQEDLALLADCALPPELRVGFGELPFDSTDNFSSCPDVCFRVANYNFLCHKAFFCGRSDYFKALLEDHFCESEELQAQPDIPVVTLHNISEDIFIRVLYYIYSDDTELSPENAYEVLGVADMYLLPGLKRLCGRSLAQVLDEDNVVNIWKVAKLFQLTRLEDQCTEYMAKIIEKLVEQAEFAEAVKEEAEAVAERQETDSIPLVDDIRFHITSNVQTYSAIEEANQKLEALEGLLANIGLEC
The following text describes a protein:
Function:
Required for the maintenance of mitochondrial (kinetoplast) genome stability. Probably has no helicase activity, missing at least two of seven conserved helicase motifs.
Subcellular Localization:
Mitochondrion matrix, kinetoplast. Note=Localizes primarily to the distal face of the kDNA disk. Localization varies with different kDNA replication stages.
Sequence:
MTRCRLVGASSGGKYISTTNAKTRPVMGCLRFASRLSALGSTQQPKFFALPLLATTRGFGHLVREVDMRGFRGDFGQLRHKNLASTQRYVTDALGAKKNVIFCGAYHTGKLTILKAIGEACEARGKKVAYVSCNPQRASRFGGFLLYHFVGLRYLFRNEIPSRDQLDGALERHARLCESTYAGCVPSLKSVDVLIFDAVDQLEPTILASMDAVCRRLRGKPNDAFGGLRVFAAADFWRLPVHPSSDTGGYIFQLDNWGELFPKQHLLKKIYGQTKALTTLVNKAYYGQLSAEDIEELEARSSAGRTESGAACGGSKKEASETSGSFSVSDDGSRQVEVEEEGAGSGLLPPQRLISNAEAIIKFTSRFPKQPSIRVLPPRFRTLKRTEIGNYIVNMMVQSSTLHSFGLVDSLNLDIGASVHLLFDGTADFGVTAGTVGEVLQVKEHALVVHFPSVHRTVDVPRMRISVYHPFYPEVRYEVQQFPLYPRHCISPINMLTYHHAYQVHIDCHQLADTNDLGNILARMRTFDDFTIERVHDFAHLDGMVHEPTRIYYQRIDNQPLSSAAEQWCRNCKSYVSTSDFYTHWDKCVRQVRWCTVCNTRIPLERLGPHQEKHQIVLCLDCGRAVEWRRWEGHRLTCSAMMREVSPENEFLPLRTRQLALEMGLDKRDLHTMKGFNRGMLPKSRKQCNGGEA
The following text describes a protein:
Function:
Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters.
Subcellular Localization:
Nucleus.
Sequence:
MQQDGLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGRYYRTGVLEPKCIGGSKPRLATPAVVARIAQLKDEYPALFAWEIQHQLCTEGLCTQDKAPSVSSINRVLRALQEDQSLHWTQLRSPAVLAPVLPSPHSNCGAPRGPHPGTSHRNRTIFSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSNRRAKWRRQEKLKWEAQLPGASQDLTVPKNSPGIISAQQSPGSVPSAALPVLEPLSPSFCQLCCGTAPGRCSSDTSSQAYLQPYWDCQSLLPVASSSYVEFAWPCLTTHPVHHLIGGPGQVPSTHCSNWP
The following text describes a protein:
Function:
Potassium transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MASVVVQTRLDIPMSDDQFKANTPSIPLRKPYGSMDLISTKTPPHHGRHSKDTKWWVVLNLAFQSIGIVYGDIGTSPLYVYSSTFSNGIKHKDDVLGVLSLVFYTLTLLPMIKYVFIVLRATDNGEGGTFALYSLICRYAKVSLIPNQQAEDRQVSNYTLELPSKRLKLASVLKSSLEKSKFAKLFLLLITMLGTSMVIGDSILTPSISVLSAVGGVKEATSALTQDMIAGISIVILVFLFMIQRFGTSKVGYTFAPILSLWFILIGGIGFYNIIKHDTTVLKAINPIYIVEYFIRNKKDAWVSLGGVVLCTTGGEALFADVGHFSVRSIQVSMCSMVYPALILAYTGQSAYLRQHPDSASDAFFKSVPGPMYWPMFVVSILASVIASQAMISGTFSVVHQSLSLGCFPRVKVVHTSANHEGQVYIPEINYFLMLACVGVTSGFKTTVKIGNAYGIAVVFVMTLTSALLVLIMIMIWKTNIFLIILYVVTIGFVELMYLSSALYKFTLGGYLPLAFSAFLMTVMYVWNNVYRRKYHYELDHMISPARLTEIFTNKNMSRIPGLAMFYSELVQGIPPIFEHYVSNVPALHSIIVFVSMKSLHVNKVPAEERYFFRRVEPRTLFAFQCAVRYGYNDVREVAFEETLITRLKEFIQEETWMQIQTLSIGGKMTESGRESDREIEHNEISKAKLAKEEKLREIMEQEIEQVEKAWEEVGIVYLIGQNEVIASKESNVMKRILVDYAYNLLRRNLRQSEAVFDIPHKRMLKVGMTYQL
The following text describes a protein:
Function:
Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MHRLSDLVWLGGLPSLLVLVTWRTVSCPYTKVEESFTIQAVHDIVSYGVRPAALARYDHRVFPGAVPRSFIGPLLLAAISYPFLLLSRFLGAVQTSADAQVVVRLCLASANVSAVNFFCQQTFKSTMPPAKQNSFSRLRDEQLVALLFMLVTAIQFHFAFWASRTIPNSLALPLVTTALALVCRNVGVLYQGKDRALVDAKVAIWLLTFSGVVLRLEIVATLVPVGLYLLVTRRISFWAGLKTGIVSGTFSILLTTVIDTYFWQDLAHANVKSLLSIYALSLRNLTSGDRPKPLWPELHALLFNVVQGKSSEWGVSPWHAYITSLIPRLLAFTGPLVVIGAAQLLRGRNSALEARARFLFLTAVMHIAVLSLLGHKEWRFAFYTLPALNVVASIGASKLARSWPGRAVLAILLLLQLGLSWFTGYVSSINYPGGNALRTLHQHIDADLQREPNGQVIVHIDVLPAMTGVTLFQSIHLNRIFQQSRLDSFRKVSPAPCGTQECWVYDKTENLPVSGHEATQAWSTFTHLITETPECAMLQDQQGRALNESEQLFEQIAPPITSFVGLRRKSFSQLTTDLLNTPLAAASILGLTSSSSQHSAGSLLRSALPVVVVEQPTVWLCRRKHDLTRSNKPTI
The following text describes a protein:
Function:
Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MADETWIPEHNGDLPLEVRQVQITDIIDEMAAPAEDILCGTLGCDSGTTDPVGEQQQTQWENRGLDNKEEEAKDVEIGVENTKLGDPAEVSTSHSIEGAEEITGEPRLELESEEDNIPMGEEPGDTEFAERCSSPLSQQPETPDLLPTEKAEKLSACQMIEVEEEELASTGHSKENGKESFYDEQENGSKYFLSLSPTGSQQDPSEGPPNSANRPDIFRHSYSRYDTVSYRKIRKGNTKQRIDEFESMMNL
The following text describes a protein:
Function:
This protein catalyzes the committed step to the synthesis of the acidic phospholipids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDWKTSEMLFPFPVYMAPLTSKFAAYKKKIANWLTVYRIFIALPTIIFIALDNQLGVLANFSVGAISISLQISLLIGGFLFLTAVISDYLDGYLARKWLAVSNFGKLWDPIADKVIINGVLIALAINGYFHFSLLIVFIVRDLVLDGMRIYAYEKKVVIAANWLGKWKTIMQMVGIVFSCFVWSFKQSEIASLNSGLFFWLLTQLPYYLAAVFSIWSFIVYNIQIYQQLKAYNSKL
The following text describes a protein:
Function:
Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export. Confers resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and sparfloxacin. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRAISSLAGPRALAAFGRNDIRGTYRDPLLVMLVIAPVIWTTGVALLTPLFTEMLARRYGFDLVGYYPLILTAFLLLTSIIVAGALAAFLVLDDVDAGTMTALRVTPVPLSVFFGYRAATVMVVTTIYVVATMSCSGILEPGLVSSLIPIGLVAGLSAVVTLLLILAVANNKIQGLAMVRALGMLIAGLPCLPWFISSNWNLAFGVLPPYWAAKAFWVASDHGTWWPYLVGGAVYNLAIVWVLFRRFRAKHA
The following text describes a protein:
Function:
Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MLFLPILILNLLIITHAIDIIPREVLFQDPKYSSVSLSPDAKQVGYVAPDENGIRNVFTRCSSCSYSRQVTFETEHPILNYVWTAIPDVILFTQDNHGDENTRIYKKNISATAIAADKTQRVVISEKPMVKAMILSNNLISETVLIGMNDENPALHNIYAFNCQTDELKLVLQNRRFSIFFFDNDLNVRLASEEGPDGEMIYYRPRSNEGARTTEQNTWVEYLRIQHDDKAITMPITFDKSNNFMYWIMGDGSDLGNLVVFPFEDPQQKEILYTAQRAQIGNVLIHPTDKTLLAVTEVYHKPELFVANETFMEDLQYLVNMKPSGSMNIVSMSIDMSTWLVTYSSSDEPYDIYLYRRWNKKAELFMSTRPELKKYTLNKQIGFDFRARDEMTIQAYLSLPPQAPLLKSSQVPDGDRPYANLGMIPAVPQKMIVLVHGGPKARDHYGFSPMNAWLTNRGYSVLQVNFRGSTGFGKRLTNAGNGEWGRKMHFDILDAVEFAVSKGIANRSEVAVMGGSYGGYETLVALTFTPQTFACGVDIVGPSNLISLVQAIPPYWLGFRKDLIKMVGADISDEEGRQSLQSRSPLFFADRVTKPIMIIQGANDPRVKQAESDQFVAALEKKHIPVTYLLYPDEGHGVRKPQNSMEQHGHIETFLQQCLGGETQPFQPGQYNSSAIIKKIGIEGAAIARQNLQIAQNQFAQQLPRGPVAPSIFYRPPVRAQRVMLAPNQNVMNRIFPVQG
The following text describes a protein:
Function:
In the presence of other necessary color factors, this glycosylation reaction allows the accumulation of anthocyanin pigments.
Sequence:
MAPADGESSPPPHVAVVAFPFSSHAAVLLSIARALAAAAAPSGATLSFLSTASSLAQLRKASSASAGHGLPGNLRFVEVPDGAPAAEETVPVPRQMQLFMEAAEAGGVKAWLEAARAAAGGARVTCVVGDAFVWPAADAAASAGAPWVPVWTAASCALLAHVRTDALREDVGDQAANRVDEPLISHPGLASYRVRDLPDGVVSGDFNYVINLLVHRMGQCLPRSAAAVALNTFPGLDPPDVTAALAEILPNCVPFGPYHLLLAEDDADTAAPADPHGCLAWLGRQPARGVAYVSFGTVACPRPDELRELAAGLEASAAPFLWSLREDSWTLLPPGFLDRAAGTGSGLVVPWAPQVAVLRHPSVGAFVTHAGWASVLEGVSSGVPMACRPFFGDQRMNARSVAHVWGFGAAFEGAMTSAGVAAAVEELLRGEEGARMRARAKELQALVAEAFGPGGECRKNFDRFVEIVCRA