lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds to a great number of different CC-chemokines including CCL5/RANTES, CCL2/MCP-1, CCL3/MIP-1-alpha as well as CX3CL1/Fractalkine. Transduces signals resulting in the activation of MAP kinase signaling pathways and augmentation of intracellular calcium ion levels, leading to alterations in chemotactic behavior of vascular smooth muscle cells and macrophages. The US28 receptor also exhibits high levels of agonist-independent signaling activity and agonist-independent endocytosis. Interacts with the host Gi complex without activating it, thereby probably interfering with the chemokine-Gi signaling. May also function as a G protein sink to sequester G protein from the cell surface via internalization. Interacts with endogenous Gaq/11 subunits and thereby constitutively activates phospholipase C.
Subcellular Localization:
Host cell membrane; Multi-pass membrane protein.
Sequence:
MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MSKLNDKHERVRARVREAFILFEHKEGSRLVDFKDVPTAVRACGVNPTAVQMTHILDQLAALNAETDATGYVGLENFELVVCNFLIQQEASLFRDDYHTLLRAFRAFDPDGRGFIDAESFKSLLTGKGEALSEDELAKMMTVAADGEGKIWYEDYAQRLANDGRTI
The following text describes a protein:
Function:
Golgi membrane protein involved in vesicular trafficking and spindle migration.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MRSSHPYRSRYAPLRHDTHASTRSISRSSQLACACVRMRSYLDTAYRGFLALPPEQRYMIYVAVGIKALILGVVIYIGPEAMFDATAKLAIWFASQSYGAVLLIGIVVIVSFPPLIGYGTSITLFGLGWGVHAQATAQHAQLNGNLLQAWLLASLACLVGATVSFSVLRFLIIHHSKRVDWISNTLNDPKYTALSTAVRRKGLVMAILIRFCPFPFAYSNLFFASLVDAVSLAQFFVATALITPKLLLHVWLGTRMFQLMDRDQRAQLDAWAKALNVIYIGVGSAVGAATGWIVWNETAKVLETIESERQSQDARSNSGTDSAQRTTTEPAYTDASDSNKSHPDSETPSPFILDFQDHTEHAMLEPHSDSSQTHRADRDMPSLLPR
The following text describes a protein:
Function:
Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
Miscellaneous:
MISCELLANEOUS: Was named PVRIG for the homology observed between its second exon and the variable immunoglobulin domain of the polio virus receptor (PVR/CD155) and polio virus receptor-like (PVRL) genes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRTEAQVPALQPPEPGLEGAMGHRTLVLPWVLLTLCVTAGTPEVWVQVRMEATELSSFTIRCGFLGSGSISLVTVSWGGPNGAGGTTLAVLHPERGIRQWAPARQARWETQSSISLILEGSGASSPCANTTFCCKFASFPEGSWEACGSLPPSSDPGLSAPPTPAPILRADLAGILGVSGVLLFGCVYLLHLLRRHKHRPAPRLQPSRTSPQAPRARAWAPSQASQAALHVPYATINTSCRPATLDTAHPHGGPSWWASLPTHAAHRPQGPAAWASTPIPARGSFVSVENGLYAQAGERPPHTGPGLTLFPDPRGPRAMEGPLGVR
The following text describes a protein:
Function:
Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MPPKKQSSSGGNKPSGSGSSSGRSSSGSSCRCSCRCRCSIGGWLKFFAILFALVAPIAYVLEQRLESFYVFDTEHLHDLSKRAISAHGNDTKAIVKYIVDELNDRNGVAPYVNNDEEWVFNNAGGAMGAMYIIHASITEYLIIFGTAIGTEGHTGRHTADDYFHILTGTQTAYVPGEYEPEVYPPGSVHHLVRGTVKQYRMPESCFALEYARGWIPPMLFFGYADTLSSTLDFPTLWRTSVITGREMISNLLKGKF
The following text describes a protein:
Function:
Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MHQQKRQPELVEGNLPVFVFPTELIFYADDQSTHKQVLTLYNPYEFALKFKVLCTTPNKYVVIDAAGAVKPQCCVDIVIRHRDVRSCHYGVIDKFRLQVSEQSQRKALGRKEVIATLLPSAKEQQKEEEEKRIKEHLTESVFFEQSCQPENRAVSSGPSLLTVFLGVVCIAALMLPTLGDMESLVPLYLHLSVNQKLVAAYILGLITMAILRT
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Sequence:
MCFGSREDVEAKRSKEIDALIHKDEKIMQRQVKLLLLGAGESGKSTILKQMRIIYTKEGFSKNEKEEWRIIIFHNILDGLRMTVEAMTDFNIPFEDENTSQYVPMITEEKDLRPLEPIPFEYLKAFKDMWADPGIQKAVDRGNEFALHDNLGYFFEDLDRLFSKEFVPTDQDVLRARLRTTGITETNFDLGSLQYRMFDVGGQRSERKKWIHCFENVNALLFLVAISGYDQCLAEDKDGNQMQEALMLWESIANSHWFKHSALILFLNKIDLFKAKLSHSPITKFGFSDFQGDTTSWQQTSKYFMDKFVALNRSPGREVYGHFTNATDTDLLKVTMSSVQDMIIQRNLQKLIL
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Subcellular Localization:
Nucleus.
Sequence:
MPPSTPQQSKKVMQMTPGKKRLKQATLMSFFKKGMGGTSPAAGAEPQRGAAVETSTPCKAEQLQLFVEDASDEGETTFVTAHDDGAVKEEGATQVESQGSARRRRSVSYAEESDDEDVVAVRRKTRRMAGDDEDAEFVPERGGGDKDASMLLEDDDDILELAAKPRTAQPRRPAPPPARRPPAVRPVRDVSPGKHSNFSKNNEERYQWLVDERDAAGRPPSDPEYDPRTLHIPAQAWARFTPFEKQYWQIKSKMWDCIVFFKKGKFFELYEKDAHLANQLFDLKIAGGGRANMQLAGIPEMSFDYWASQFIQHGYKVAKVDQKESMLAKEMREGNKGIVERELQCVLSGGTLTDLKMLHSDQSTYCLSIHEAPLALYAMERGEAVPPEAQQQGRLFGTAFIDTATGRICLLEFEDDSECTQLDTLMAQVRPKEVVMEKRNLSVIAHKIVKFNSQPDCIFNYRTSAEFYDYARTFDEVSNGGYFAGMDSWPAILKQYYDQGKKVGFSAFGGLLSYLQWLKLDKSLLSMGMVEEYNPLKAQTSLVLDGITLQNLEIFANSFDGTDKGTLFKLVNRAITPMGKRQMRTWVMHPLLRKEHIEERLDSVDQLLNEMPIRDLLESSLTGLPDLERLLARVHSGNLPIKDFDKVICGFENIVRLISSLNEYELSGSLSRFLHDIPSTLKSDVESWTTLYDRNMAVSEGKVVPNAGVEPDFDVSLSKMRALEEELDAVLSEYKRSFKCSKIQYKDSGKELYTIELPISIAKSVPSNWTQLGANKSTKRYYSPKVQKLARSMAEARELHKILEEGLKGRLYQKFDQNFSTTWFPTIKAISNIDCILSLARTSESLGFPACRPNFKDEIDPTTGHKLNGYLSFKELRHPCYNAGVNGATEFIPNDVHLGKSTAQIALLTGANAAGKSTILRMTCIAVIMAQLGCYVPCEDAELSPMDRIMTRLGANDNIMQGKSTFFVELSETRKILDMATNRTLIVLDELGRGGSSSDGFAIAEGVLHHISTHVQSLGFFATHYGTLGQSFTHHPMVKPLQMAILVDEGSKKVTFLYKLIEGQSEGSFGMHVAAMCGIPRSVVENAERAAESFEHTSRILKERKRYINDEHVVPLGLQSDFVRLVFGDGLKKTALGSGEGVKYYDKRIKANVLRNIISMVDGLNEN
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil.
Sequence:
MLEIPAPTAVFSFVIDEQLTGRLDKGLVSYNGAYSRAFYQQQIELGRVRVNGRVYTRVSHPLSLGDVVEVELIEEEEPSSLIPEDIPLDKVYEDDMMLVINKPRDMVVHPAPGHTQGTVVHALLHEIGERLKQEFPEEPWRPGIVHRLDKDTSGLLITVKTRRAKALYSELFATKQVKKLYVAICINAPSQERIHTRIARHPLKRKEMTVLSTHAEGGKEAITHCQVLATNGRLSVVALYPETGRTHQLRVHMKHLGTPILGDPVYGIPSINFRYGLDKQQLHAYSLVFAHPESAERVKLVTKLPDDMTSLIEKEFREGVSILDGSCDWFKITR
The following text describes a protein:
Function:
Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Localizes to the brush border membranes of cells in the proximal tubules of kidney. Colocalizes with SLC6A19 in the early proximal S1 tubule.
Domain:
The cleavage site containing the double Phe-Phe motif acts as negative regulator of shedding by BACE2.
Sequence:
MLWALFFLVTTIHAELCHPDAENAFKVRLSIRAALGDKAYVWDTDQEYLFRAMVAFSMRKVPNREATEISHVLLCNITQRVSFWFVVTDPSNNYTLPAAEVQSAIRKNRNRINSAFFLDDHTLEFLKIPSTLAPPMEPSVPVWIIVFGVIFCIVTVAIALLVLSGIRQRRRNNKGPPGVEDAEDKCENIITIENGIPCDPLDMKGGHINDGFLTEDERLTPL
The following text describes a protein:
Function:
Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Subcellular Localization:
Endomembrane system.
Sequence:
MPPPAASSRYPSPSQPSGKSEVTDLKSQLRQLAGSRAPGVDDSKRDLFKKVISYMTIGIDVSSVFGEMVMCSATSDIVLKKMCYLYVGNYAKGNPDLSLLTINFLQRDCKDEDPMIRGLALRSLCSLRVPNLVEYLLGPLGSGLKDNNSYVRTIAVTGVLKLYHISASTCIDAEFPATLKSLMLHDSDAQVVANCLAALQEIWSLEASHSEEACREKESLLSKPLIYYFLNRIKEFNEWAQCLILELAVKYVPSDSNDIFDIMNLLEDRLQHANGAVVLATVKVFLQLTLSMTDVHQQVYERIKSPLLTLVSSGSPEQSYAILSHLHLLVVRAPFIFASDYKHFYCQYNEPSYVKKLKLEMLTAIANESNTYEIVTELCEYAANVDIEIARESIRAVGKIALQQYDVNAIVDRLLQFLEMEKDYVTAETLVLVKDLLRKHPQWSHDCISVVGGISSKNIQEPKAKAALIWMLGEYAQDMSDAPYILENLIENWEEEHSAEVRLHLLTAAMKCFFKRAPETQKALGIALAAGIADFHQDVHDRALFYYRVLQYDVHVAESVVSPPQQAVSAFADTQSSEIKDRIFDEFNSLSVIYQKPSYMFTDKEHRGPFEFSEELGSTSITPEVSSDIVPAQQFEANDKDLLLSTDEKDDNKGLSSNNCSAYTAPYESSNISSQMQELAISGPAASATTTQSSFDFDDLLGLGLSAAPAPTPSPPLLKLNPRASLDPRAFQQKWRQLPISLTQEYSVNPQGIAALTVPQSLIKHMQSHSIHCIASGGQSPNFKFFFFAQKEAEPSDYLTECIINSSSAKAQIKVKADDQSTSQAFATVFETALSKFGMP
The following text describes a protein:
Function:
Low-affinity zinc transport protein. Active in zinc-replete cells and is time-, temperature- and concentration-dependent and prefers zinc over other metals as its substrate.
Miscellaneous:
MISCELLANEOUS: Inhibited by Cu(2+) and Fe(3+) ions.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVDLIARDDSVDTCQASNGYNGHAGLRILAVFIILISSGLGVYFPILSSRYSFIRLPNWCFFIAKFFGSGVIVATAFVHLLQPAAEALGDECLGGTFAEYPWAFGICLMSLFLLFFTEIITHYFVAKTLGHDHGDHGEVTSIDVDAPSSGFVIRNMDSDPVSFNNEAAYSIHNDKTPYTTRNEEIVATPIKEKEPGSNVTNYDLEPGKTESLANELVPTSSHATNLASVPGKDHYSHENDHQDVSQLATRIEEEDKEQYLNQILAVFILEFGIIFHSVFVGLSLSVAGEEFETLFIVLTFHQMFEGLGLGTRVAETNWPESKKYMPWLMGLAFTLTSPIAVAVGIGVRHSWIPGSRRALIANGVFDSISSGILIYTGLVELMAHEFLYSNQFKGPDGLKKMLSAYLIMCCGAALMALLGKWA
The following text describes a protein:
Function:
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (DGC). May also act by slowing calcium channel activity via a direct or indirect mechanism potentially involving other second messengers. Plays an early role in the formation of the neuromuscular junction and is necessary for muscle maintenance.
Subcellular Localization:
Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Sequence:
MAAVRSGLVDIFVQGQWHRVLATLDPTAITLQTMEQNEAEAEKRTVRVVKYDGNGLGISIKGGRDNNMPIVISKIFKGMAADQAGELFLDDVIISVNGENLLDASHEEAVRALKRAGRVVDLQVQYRREDMMHRENIVENVEWDDDIRERVRTIGLKLAYVARAGIDADAEGRILEMRSPSGRYSLAMRCSSSEEADGWFEALHACTTCLLTQALAQVNIMLGNNPQVRHMGWIAEQVSENGISMWKPKFMTLTNSEILFYEAVPQLKAEWAEPRLVRPLVATRVVQTSSRTAPVIKGLTDVISFRMRTGTQQGVRTHTIRVETHAELARWVRAVVIGGYEACLSTSQVSAPCLWRGESCELIVNLDNGISLLSSTGEVLWQHSFETIRATGDDGGRFLWVDFGPPHGEQELDLLNSAKPVVFILHSFLATKVYRLGLYA
The following text describes a protein:
Function:
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
Sequence:
MKVFKQQLEQLGAQNQYRSIPDLIHQGRYITRENRKMLNMSSNDYLGLASDENLRRSFLQQYGGNFPSFTSSSSRLLTGNFPIYTDLEELVAQRFQRESALLFNSGYHANLGILPALTTTKSLILADKFVHASMIDGIRLSRCAFFRYRHNDYEHLKNLLEKNVGKFDRTFIVTESVFSMDGDVADLKQLVQLKKQFPNTYLYVDEAHAIGVYGQNGLGIAERDNLIAEIDLLVGTFGKALASVGAYAVCNQVLKECLINQMRPLIFSTALPPFNVAWTYFIFERLPQFSKERSHLEQLSAFLRREVAHRTQIMPSQTCIVPYILGGNEATLAKAEYLQRQGYYCLPIRPSTVPKNTSRIRLSLTADMTTDEVRQFAACL
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGSMFRSEEVALVQLFLPTAAAYTCVSRLGELGLVEFRDLNASVSAFQRRFVVDVSRCEELEKTFTFLQEEVRRAGLVLPPPKGRLPAPPPRDLLRIQEETERLAQELRDVRGNQQALRAQLHQLQLHAAVLRQGHEPQLAAAHTDGASERTPLLQAPGGPHQDLRVNFVAGAVEPHKAPALERLLWRACRGFLIASFRELEQPLEHPVXGEPATWMT
The following text describes a protein:
Function:
Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.
Sequence:
MSLQIAVAHTGQRLDADPVAFSSVDALKHWIARAFEIPPESQILLTPGGKHVKVQALLTEKEIFVYSRELSSNPKAAVSSTPLPDVFTPDDPPNTLSNNTDLGAWQTLFQARRDWAFDVLEKSHSMSRIATKYFAEQATIAKGTQIAVGNHDSHIQGLDAKYKAAKEWFDGVEKEAGDNLRRLDADFGQLGGIPAKVEFAQFLAKEMRSAEAAQNARKSALSRTASLQEFLDIDAVKRATGTSKRVREAIRKRMAVMNTQLEKIGADYQELLGAVGQSQSRSLVDDSEEPLRLYNEIDAVAKKVESDFEHVMGLEASSKSVAQVSKMALLHTRNFLPAIKEYSVEMSDLLRRSVEQKDFAIRNSVESMQGITNIESVITSINAELDAFGIPDEGVAAFELISLVGRLPYVYGTLLIEAVRRREWTERLQKDTSSLAEEMATFQEEEERRRKKWLKPIAEVVNLEAVQGGIVGFEMNVQPEKNIWPVVNRDDLVEYHQILQGLEGQSTEAEALGHAIKDLDRPTKQQIKRAKNFKMGSVHEPAFGKASALMVRGDDELRVIKEANLKLEDELRGSKSRGQDDKRRVVRLEQELAAEKEARANLEKQAQARRDEDAESQRRFEEAMSTKNNIMENMKAQQREFADERRSLESEIQAYKTKIEEAEDELDRVLGSRDHERTGVDARVQELASELEKARNEAAEHSRDAETRVASLQSELDKRTQAQTQHMESLATVLTQLAPGESIPEEHAALVSRLEDLAARSFSHQKELEQAVAIAKSENDNTRTQMEEQENKLKSRTTDHEKEIAAVREQLETEQAKFVSISSELEDERRQLHDIRAKFAEGETGSEELRKRVEEEEAKVGRLRIELAEKNSHINGLDIELMRLEKKVLKYEELDSSRTHQRVARARDLSQRLYTQHERLVRLLEALGFVIIQENGEMVLQRASKLGNSTVMSDTNAGLSRSTTTPSPTPLKRFLDDIGDLSFLQWTESASPEEEDRRYQELIDKLDMFNLETFSDAVAKRMRDMEHTARKWQKEARAYRDKSHRFQADAHDKIAYRSFKEGDLALFLPTRNNAHRPWAAFNVGAPHFFLREQDSHRLHGKEWLVARISKVEERVVDLSKTLESGPRASPDGRSIASSNAVSFEDDNPFELSDGLRWYLLDATEEKPMAPGTPGIKGAVTVKSSLETGQGEMQRAKKKSSMDPATQLGKSLDSRRSSGNSKKSVPVVGGKPSAEVLSPSENADSNPNSNTATRGASPAGAHGPSHLRETETSNNNGNETVAARMVEDQEGLNSVSTRLTYVPGSSSQSQSPTYATEAWAVE
The following text describes a protein:
Function:
Required for replication of Brome mosaic virus (BMV).
Miscellaneous:
MISCELLANEOUS: Present with 5370 molecules/cell in log phase SD medium.
Sequence:
MLVPPANFGIAEEGIYRCSKVETLNLSFLETLNLKTAIFIGGQEPSKFFKDFFTRSSIKWIVLRMSDFSAAAVPVKSSSVSNANLYSNNNSTLSLQEEKKKSTANGSQNSTTGDPVIQEELAYHLTDNDDLMLIKSTCLKRTFKTLLNVDNYNVLLVDKTALVIGILRKIQKWNIASIINEYRLFSGKNRNYFAETFLEIINIEIEQEKDNKTIVDNKAKKLPLENNRTHSIEYKANSGKLIRVNEDDLCREPEVPQRLLTLINQIETKVKNNKVLQVSGVLGDDLKKTSSDLGIFGHRYRLAFNKKENGDYGYYKARGKDNVKIRIPCDSELPDWFRFQRDLWEKENVPEEHHFYREHIFT
The following text describes a protein:
Function:
Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin.
Sequence:
MKTVAALTLLAFATAANGQFLQDCTNALDGLYALGECEPQFLTCSGGIARIMDCPADLIYNEPLLICDWRHNVIGCEGSGESSGETSGEGSGESSGEASGEGSGEASGEGSGEASGEGSGEASGEGSGSGEETVENVCENLEDGAYSSGGCTTYYFFCTTNTARFLSCPTPLFYDADSQKCIWKSLVEECKEDLTITDGSGETSGEGSGEASGEASGEGSGEASGESSGQGSGEASGEGSGELEPTCEGKADGIHPNGVCSTNFLTCSGGIARIMDCPASLVFNPTILVCDWPRDVAECAGLPTPQPTCEEDGYFSFGQCSSSFTACTNGRAIVMFCPAGLKFSESTVRCDYESNVSECQETSGEESGEASGEQSGEGSGEASGEASGESSGEGSGVEEQNQCVGLDNGLHAIGCSPRVLSCQNGHVDIFECPSSLVFNDQSLICDYPQTSLKCLIEDTILIDETPIAAFDCSTDGLFSDGLCSATYHQCTAGQLINFTCAASNAVFSAANTECVDSSTLLQCH
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MDTAIVQCPANEALAAFLVEKREEWFLKQRSDNLDSVFIGAHKSVCESTVPLHSLRAASKVKGIGKWLLKILAEFFNVDEDEADDEDEEQPSGSQRAKKATRRYLPKKSSAPYAILITLYRAHMLGKEFMMRQELIDAAEASGLASMPIESNKGTLPPRFGGGPHYSYSGWSSMKTLLEKGLVVKKSNPAKYMLTEEGHKTAEECQGRAGLGPADHTRPPVSDEIPPVNARPAPGRAEKATTTRPRASKSKSNGAVGKASTLDVNKLKAMGYGEQDIQLALNEATSTDGLQDSDVWGFVLGILSRGGKEKTAAAIGPVSQPAVQPFVERGTMPTNSSWYHSAPVVTVEAAVPSTSTAPSGRLSTSAQTMDVHQTGYNEVAVPPLEVGQGFGQVYEVFLVLDSREQFRRDARGGAALQKFADRIGVQFQVQVETRQLPVGDALWIARHKVLRHEYVLDFIVERKRVEDLWASIKDNRYKQQKLRLQRCGIKRLVYLIEGDPNLTDASESLKTATFTTEILEGFDVQRTRDTSETVQKYGQLTTAIIDRYSLEVGKPGRHPGGYCMRYVEFVNFCKDVEMERVTDVFGVQLMQVRNVTEDMALSILERYPTLHSLALAYTELEGDVQAQEQLLKDIPIRNKNKTISANISKNIYKLVWAP
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MVANGKEVDHFSDEEDSDLEIDYTDIEERFRPKFQDTFDNLIVVEGAPIVDESKRGRLIKAIISTFAKKDLKISESKIEMPLDPNNQSKGYLFIELNSPQDADRAVRNLHDYPFDKKHRFTVIKFTEVERFAHVAENFVKPVLEEYKPRSHLKSWLADPQGRDQMIIYQGDDVKVAWHGRNGAPDVAHKRTKWTDAYCAWSPDGTMLATIHNQGVALWGGANFDRIHRLYHPKVKLIDFSPMENYLVTWSDQPIELPTDPQAPQIFSEDDEGNSIAVWDVVTGKLLRTFPVLTPSSEEEGGARIKFQWPMFKWSGDDRYLARVTPGQAISVYETPGMGLLDKKSIKIEGVVDFEWCPLSENERDAILEARNLLPSASFDEPSSDSKPKKNAGERSNMLAFWTPEVANQPARVSLMNIPSRDTLRSKNLFNVHDAKIHWQSNGDYVCVKVDRHTKTKKTTYCNLELFRVRDKSFPVDVIEIKDTVTAFAWEPKGNRFILITSNDPNLSQGPTPGTTIKTNIHFFGMDVKKGDFRLFKTYDGKTCNSVHWSPKGRHVVTATLGSSSKCDLEFWDTDLDESDKDLGSGISLLSSVEHYGMTELEWDPSGRYLASIGSMWLSSLECGYTIWDFKGELMHKVTLERFKQLLWRPRPRSLLSKETQRKIRKNLREYSKQFEEEDQLEASNVSAELVAHRRRLLEEWDSWRRHSKQELATEASRAGKLSAAQKAADPADSEQIEEWIEEVIEETETML
The following text describes a protein:
Function:
May play a role in the regulation of membrane traffic through the trans-Golgi network.
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MAARDRYGAYADVGLTPLQRAIRNACDFSLYEPNLALNLEVADLINSKKGNAPREAAFEIVRLINSRNQNVALLALALLDICVKNCGYPFHLQISTKEFLNELVRRFPERPPMRPSRVQHRILESIEEWRQTICQTSRYKEDLGHIRDMHRLLLYKGYMFPEIRHEDAAVLNPSDNLRSAEEMEEEEREAQSAKLQELIRRGTPADLQEANRLMKVMAGFDTRHKTDYRAKAAEEVAKVQQKAKILEEMLQSHKPGDRIAEGDVFEELASALQSAHPKIQKMCEEESDDPEAVHKLLEINDSIHRTIERYKLVKKGDYDAASKIPKGTLGTTTGVSKNANNELSLIDFDPEPSSNGNAPPPAGGSSLENDLLGLSIEEPVPAGSISLGPGNLTTSANAPLQQAPAGFKPTYDIMASFNSSRPVSQSSTPAPRPPQQPTATPTPPPPPASDPFAALVSASPRTSSPFPPGASSTQSPAAASSALLDLVGAGPPTTAAASGSSAQTQDDDEWNFASSLPESNALPTTNKVQVLNSSLRIEFVARRHPNQPKQIHVVALFSNTTGQPLNELHFQVAVEKAYTLQLRPQSGRDIGPLQQNGVQQEMLLDGVDAGKGNSVKVRFRVSYRLGAERKEEQGMVPPLGIA
The following text describes a protein:
Function:
Potential calcium-dependent cell-adhesion protein.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MYLSICCCFLLWAPALTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIRSVSGSLPEGVPRVNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKEIRTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNAMNVMNVVSSPSLATSPMYFDYQTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFTGQGTNASETPATRMSIIQTDNFPAEPNYMGSRQQFVQSSSTFKDPERASLRDSGHGDSDQADSDQDTNKGSCCDMSVREALKMKTTSTKSQPLEQEPEECVNCTDECRVLGHSDRCWMPQFPAANQAENADYRTNLFVPTVEANVETETYETVNPTGKKTFCTFGKDKREHTILIANVKPYLKAKRALSPLLQEVPSASSSPTKACIEPCTSTKGSLDGCEAKPGALAEASSQYLPTDSQYLSPSKQPRDPPFMASDQMARVFADVHSRASRDSSEMGAVLEQLDHPNRDLGRESVDAEEVVREIDKLLQDCRGNDPVAVRK
The following text describes a protein:
Function:
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIQSSNVFLIPFQAAYAVLVFTLFFKSVDMLRRPNSSRALFFTALATYGTGFIIWNIDNFFCHNIREFRGTLTSTFRPLTQLHAWWHLLAGLGTYIHVLYSVQVRTNYLKWPGKVKTIMGIPYYHVSKKVEKNGPVHKD
The following text describes a protein:
Function:
May act as a GTPase-activating protein for Rab family protein(s).
Sequence:
MEAAGRAQAARDRVPRIDPYGFERPEDFDYAAYEEFFSTYLVILTRRAIKWSKLLKGGGGVQRSMTVKRYIRKGVPLEHRARVWMGVSGAQARMDRNPGYYQRLLQGERSASLEEAIRTDMNRTFPDNVRFRKDAEPCLQGPLYNVLLAYGHHNHGVGYCQGMNFIAGYLILVTKSEEEAFWLLDALVGRILPADYYSPSMLGLKTDQEVLGELVRTKLPAVAALMHSHGVLWTLVASRWFICLFVDVLPVETVLRVWDCLFSEGSKIIFRVALTLLKHHQASILEATSVPDLCEKFKEITRGRFVTECHSFMQRIFLEPGSLSRASIARLRERCRARLLAQG
The following text describes a protein:
Function:
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Sequence:
MFELETDLRIIKWMSGSIFMAGILSLAAYQVGVPSGYGKHTKKSKFTVDARLAWVIQECPSFFLPVLVTYSVGVENINFSNLLIISAFAFHYFQRSFIYPMLMNRMSTPLPLRIVFMSFTFTFINGYAISKYEAAHVSLPENWINSFQFLTGMLMWASGLLINIHSDHVLRNLRKPNEVGYKIPRGGAFEYVSGANFSGEIFEWFGLLIASNFHFPLICFSLSTSLTIGTRALFHHKFYLSKFEDYPKNRKAVIPFVL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1.
Sequence:
MASYFDEHNCEPTVPEEQYRQNALLELARSLLSGMDIDLGAVDFTEWDQRLPPPASKKVVESLPKVTVTPEQADAALKCPVCLLEFEEGETVRQLPCEHLFHSACILPWLGKTNSCPLCRHELPTDSPDYEEFKQEKARRQQKEHRLECLHGAMYT
The following text describes a protein:
Function:
Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM.
Sequence:
MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGHWVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG
The following text describes a protein:
Function:
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
Subcellular Localization:
Mitochondrion.
Sequence:
MVGGVTPGKGGTEHLGLPVFNSVAEAKAEAKANASVIYVPPPFAAKAIMESLEAELDLIVCITEGIPQHDMVRVKAALNQQSKTRLIGPNCPGIIKPGECKIGIMPGYIHKPGRIGIVSRSGTLTYEAVFQTTAVGLGQSTCVGIGGDPFNGTNFVDCLRKFLVDPQTEGIVLIGEIGGTAEEDAAALIKESGTEKPIVAFIAGLTAPPGRRMGHAGAIVSGGKGTAQDKIKTLREAGVTVVESPAKIGTAMLEVFKQRGLV