The following text describes a protein:
Function:
Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel activity. Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. Likely to be involved with polycystin-1-interacting protein 1 in the detection, sequestration and exocytosis of senescent mitochondria.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, cilium. Endoplasmic reticulum. Golgi apparatus. Secreted, extracellular exosome. Vesicle.
Sequence:
MPPAAPVRLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGLRTLGPALRIPADATALDVSHNLLRALDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSGNPFECDCGLAWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGCGEEYVACLPDNSSGTVAAVSFSAAHEGLLQPEACSAFCFSTGQGLAALSEQGWCLCGAAQPSSASFACLSLCSSPPPPPAPTCRGRTLLQHVFPASPGAALVGPHGPLASGRLAAFHIAAPLPVTATRWDFGDGSPEVDAAGPAASHRYVLPGRYHVTAVLALGAGSALLGTDVQVEAAPATLELVCPSSVQSDESLDLSIRNRGGSGLEAAYSIVALGEEPARAVHPLCPSDTEIFPGSGHCYRLVVEKAAWLQAQEQCRAWAGAALAMVDSPAVQRFLVSRVTRSLDVWIGFSTVQGVEVGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELRPGGPVQDAENLLVGAPSGDLQGPLTPLAQQDGLSAPHEPVEVMVFPGLRLSREAFLTTLRLQVYRLLSTAGTPENGSEPESRSPDNRTQLVPACMPGGCWCPGANICLPLDASCHPQACANGCTSGPGLPGAPYALWREFLFSVPAGPPRAVLGVTLHGQDVLMLPGDLVGLQHDAGPSALLHCSPAPSHPGPQAPYLSANASSWLPHLPAQLEGTWACPACALRLLAATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAPHHGRLYVPTNGSALVLQVDSGANATATARWPGGSVSARFENACPALVATFVPGCPWETNDTLFSAVALPWLSEGEHVMDVVVENSASRANLSLRVTAEEPICGLRATPSPEARVLQGVLVRYSPVVEAGSDMVFRWTINDKQSLTFQNVVFNSAAVFKLSLTASNHVSNVTVNYNVTVERMNRMQGLRVSTVPAVLSPNATLALTAGVLVDSAVEVAFLWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVTHTYAAPGEYILTVLASNAFENLTQQVPVSVRTSLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPAANHTYASRGTYHVRLEVNNTVSGAAAQADVRVFEELRGLSVDMSLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSGPEATVEHVYLRAQNCTVTVGAASPAGHLAQSLHVLVFVLEVLRIEPAACIPTQPHARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPTVTHNFTRSGTFPLALVLSSRVNRAHYFTSICVEPEVGNVTLQPERQFVQLGDEARLVACAWPPFPYRYTWDFGTEEAGPARAGGPEVTCIYRDPGSYLVTVTASNNISAANDSALVEVQEPVLVTSIKVNGSLGLELQQPYLFSVVGRGRPASYVWDLGDGGRLEGPEVTHAYNSTGDFTVRVAGWNEVSHSEAWLNVTVKRRVRGLVVNASRTVVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVLQLIEGLQVVGGGRYFPTNHTVQLQAVVRDGTNISYSWTAWRDRGPALAGSGKGFSLTALEAGTYHVRLRATNMLGSAWADCTVDFVEPVGWLMVAASPNPAAVNTSVTLCAELAGGSGVVYTWSLEEGLSWETTEPFTTHSFPTPGLHLVTMTAGNPLGSANATMEVDVQVPVSGLSIRASEPGGSFVAAGSSVPFWGQLATGTNVSWCWVVPGGSSKRGPHVTMVFPDAGTFSIRLNASNAVSWVSATYNLTVEEPIVGLVLWASSKVVAPGQPVHFQILLAAGSAVTFRLQVGGASPEVLPGPRFSHSFPRVGDHVVSVQGKNHVSWAQAQVRIVVLEAVSGLQVPNCCESGIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDAVQYVALRSGPCFTNRSAQFEATTSPSPRRVAYHWDFGDGSPGQDTDEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATVTVQVLACREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRPARVALPGVDVSRPQLVLPRLALPVGHYCFVFVVSFGDTPLARSIQANVTVAPERLVPIIEGGSYRVWSDTQDLVLDGSESYDPNLEDGDQTPLSFHWACVASTQREAGGCALNFGPRGSSTVTIPRERLAYTFSLTVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDETTTSTGSAGMRLVLRRGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLGAVHALTTKVHFECMGECRPRDPPTLTSWRCWCPAGGSLSSYEAVLPPGFRPHFEVGLAVVVQDQLGAAVVALNRSLAITLPEPNGSATGLTVWLHGLTASVLPGLLRQANPQHVIEYSLALVTVLNEYEQALEVAAEPKHERQRRAQIRKNITETLVSLRVHTVDDIQQIAAALAQCMVSFPPPIWQGIIAWVTGPMGTAGSEGTGPGMGSGTLTSNLAEPGLTSTAPSLPRTRDPAGSYHLNLSSHFRWSALEVSVGLYTSLCQYFSEEDVVWRTEALLPLEETSPRQAVCLTRHLTAFGASLFVPRSHVRFVFPEPTVDVNYIVMLTCAVCLVTYMVMAAIVHKLDQLDASRGHAIPFCGQWGRFKYEILVKTGWGRGSGEGRSGVAGPPLLSLAGAGTGERPESPGLGVSQLVSSSPSTCLRCLCTSSLAALGPGISAWWPDAVAQPRWSLAPGDTSRSLASGSPTHCWDLKGIHMFPCPEAGMNSQPTMSLRSSTPGEKTETVALQRLGELGPPSPGLNWEQPQAARLSRTGLVEGLRKRLLPAWCASLAHGLSLLLVAVAVAVSGWVGASFPPGVSVAWLLSSSASFLASFLGWEPLKVLLEALYFSLVAKRLHPDEDDTLVESPAVTPVSARVPRVRPPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGHAYRLQSAIKQELHSRAFLAITRSEELWPWMAHVLLPYVHGNQSSPELGPPRLRQVRLQEALYPDPPGPRVHTCSAAGGFSTSDYDVGWGSPHNGSGTWAYSAPDLLGAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFVELTRYSPAVGLHAAVTLRLEFPAAGRALAALSIRPFALRRLSAGLSLPLLTSVCLLLFALHFAVAEARTWHREGRWRVLRLGAWARWLLVALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAVLLVSSCVDSLWSVAQALLVLCPGTGLSTLCPAESWQLSPLLCVGLWALRLWGALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRHKVRFEGMEPLPSRSSRGSKVSPDVPPPSAGSDASHPSTSSSQLDGLSVSLGRLGTRCEPEPSRLQAVFEALLTQFDRLNQATEDVYQLEQQLHSLQGRRSSRAPAGPSRGPSPGLRPALPSRLVRASRGVDLATGPSRTPLRAKNKVHPSST