lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Directs RNA polymerase II nuclear import.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MADATAADLAAKMEPQGSVAAAAGPRRVVVRVKRRHDEDPWQAFELQGKRSKQVSHAVYHRIQTVRANQDTGPSQSELLRRIKEQDPELFKAHGSKSALKERAGASVKQHNTGSAAATRARKARFQKVEAVRVLGSLSTKQDSAPDTKRAAAKRQPSPPASSTTPGTDPTSDDDVQLVEIETAGVQADRASNIMSAMTLSANGIPLVSRTLDAAEQRYRAQAATTRRQAILSRLPGTTGPATSIRRPTDTEPPVQTQEAPSEYVYDYYVTTDDANIDFSVDELEMQQWFDSLPDDADEPKYSDDDDSNEEDNWRNDYPDEESDVDVDPYDSDEPSSGRRYLAGPTAVDLSTQAHASVLGWKADPQLFGELSRWTEGAFVPDLGEDLEDDIDDEDPDALDHSQDSDDMEWS
The following text describes a protein:
Function:
Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CGAS and SNAI1. The ECS(SPSB3) complex catalyzes 'Lys-48'-linked ubiquitination of nuclear CGAS in cycling cells, leading to its degradation. Recognizes and binds nucleosome-bound CGAS: ubiquitination and degradation of nuclear CGAS during G1 and G2 phases is required to promote low intranuclear CGAS abundance before the next mitotic cycle. The ECS(SPSB3) complex also mediates ubiquitination and degradation of phosphorylated SNAI1.
Subcellular Localization:
Nucleus. Note=Nuclear SPSB3 levels increase during interphase.
Domain:
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
Sequence:
MARRTRSSRAWHFVLSAARRDTDARAVALAGSSNWGYDSDGQHSDSDSDPEYSSLPPSIPSAVPVTGESFCDCEGQNEATFCNSLHTAHRGKDCRCGEEDEDFDWVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGDGQHFWEIKMTSPVYGTDMMVGIGTSDVDLDKYHHTFCSLLGRDEDSWGLSYTGLLHHKGDKTSFSSRFGQGSIIGVHLDTWHGTLTFFKNRKCIGVAATRLQNRRFYPMVCSTAAKSSMKVIRSCASSTSLQYLCCYRLRQLRPNSGDTLEGLPLPPGLKQVLHNKLGWVLSMNCNHWKSPVPPPGTATPGAESLETRPCQRKRCRRS
The following text describes a protein:
Function:
Catalyzes the cleavage of thioester bonds from S-palmitoyl-CoA or S-palmitoyl-N-acetylcysteamine (unbranched structures) but does not have activity against palmitoylcysteine or palmitoylated proteins, branched structures or bulky head groups. Conversely, hydrolyzes both long and short chain fatty acyl-CoA substrate.
Subcellular Localization:
Lysosome.
Sequence:
MPGLWRQRLPSAWALLLLPFLPLLMPAAPAAHRGSYKPVIVVHGLFDSSYSFRHLLDYINETHTGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMEKAPEGVHLICYSQGGLVCRALLSVMDNHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRVCYSPWGQEFSICNYWHDPHHDDLYLNASSFLALINGERDHPNATAWRKNFLRVGRLVLIGGPDDGVITPWQSSFFGFYDANETVLEMEEQPVYLRDSFGLKTLLARGAIVRCPMAGISHTTWHSNRTLYDTCIEPWLS
The following text describes a protein:
Function:
Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Late endosome membrane.
Sequence:
MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWLIGGLVLSVGIYAEAERQKYKTLESAFLAPAIILILLGVVMFIVSFIGVLASLRDNLCLLQSFMYILGICLVMELIGGIVALIFRNQTIDFLNDNIRRGIENYYDDLDFKNIMDFVQKKFKCCGGEDYRDWSKNQYHDCSAPGPLACGVPYTCCIRNTTDVVNTMCGYKTIDKERLNAQNIIHVRGCTNAVLIWFMDNYTIMAGLLLGILLPQFLGVLLTLLYITRVEDIILEHSVTDGLLGPGAKSRTDTAGTGCCLCYPD
The following text describes a protein:
Function:
Involved in both the tricarboxylic acid (TCA) and methylcitric acid cycles. Has both 2-methylcitrate synthase and citrate synthase activities. Catalyzes the condensation of propionyl-CoA and oxaloacetate to yield 2-methylcitrate (2-MC) and CoA, and the condensation of acetyl-CoA and oxaloacetate to yield citrate and CoA. Has 2.3-fold higher activity as a 2-methylcitrate synthase. Catalyzes the formation of either (2S,3R)- or (2R,3S)-2-methylcitrate.
Miscellaneous:
MISCELLANEOUS: Bifunctionality as a citrate and 2-methylcitrate synthase is likely important in the mother cell's physiological milieu.
Sequence:
MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSETKSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTGLSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSANFLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASLKGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMMKEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPIFFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS
The following text describes a protein:
Function:
Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
Sequence:
MWYGQLVIGPPGSGKSTYVAGVTHILKQINRKTVIINLDPFIENDIYEADINISDLIDIEKVFSDMGLGPNGTLIYCMEYLLINIDWLEEKLNTYKDCYLIIDTPGQVELYTHNDALKNIILRLNKLNCRLTSVHIVDSTLCSDGYKYISSLLLSLCSQIHLELPHVNVFSKIDLLKYFKNDLKFPLSYYVEAQNLNQLILYETYKNGSSSEDENLSYNYNKNLNNKTTNTNVENYNKNVMGKDNINYNELKQDPFLYDIIKNEKKNYKKYSNKFLKLNEYICETVEDYNLINFALLDIQDKFSVLKLLKIIDGANGFRFTSIYSEYSLFDTYVENVEYDCDEIEEKIMATSDEDEKK
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MMNRAAALRKAAALGPLSAARSRGAAGARTYASDANGTSRSGLGRLFVYSTVGATVFYGISTVAALNNDRYNHFFVESIPGGERIIDYLDTHDVGQEIKSINLHGYGDKAIDVTKTAYDSVSGAVSRVFSGDAGASESAGDERDARLRVSEARATAKAEADKLAQRAKVAAEKAEHQAESALQAVQDKTSELVNRAKAAAERAEAKVRGQTTEASKDGRNIIQRAVDSVQVMTDIGANTKAAPSKSAAPGNGPKEEVKETYIGELPVNHEAPVGYAAPRRDRGLQAPDHPTARLRPDPEAPKLPLLAPSIKSLSASEPMIAQLAGTIDELTVFLKETPSSGAKAKGVLESAQIDLEQLSQRLETIKRQEAKRVEDSLAAQAKRYETQISKQSQEAADKLSSRESDWQKSFEEEHAKQTQQFKEKLEKELATQSQIINERLKEEVIAQGIELQRRWMKDIKAKVEEERGGRLSKLDELATDLKSLEKVSLDNSSVLDENLSVHTLWTAVRAVQHALDDASATKRPFAEQLRVLKGTSKARDDPVLSAAIEALDASGAADTGVETFTTLKQWFDDKVGPRVRQVSLVPSPETSGVLSHLASAALSPILFHKKGLVPGQDVPSVLARAEYYLDRKDLDSATRELNQLKGWPKLLASDWLAASRKRLEVQQALDVVQTEASLASLMVSA
The following text describes a protein:
Function:
Probable thiol-disulfide oxidoreductase required for pollen tube growth and pollen function in the pistil. Seems not to be required for in vitro pollen tube growth. May be involved in the generation of lipid signaling molecules in pistil.
Sequence:
MAETSKQVNGDDAQDLHSLLSSPARDFLVRNDGEQVKVDSLLGKKIGLYFSAAWCGPCQRFTPQLVEVYNELSSKVGFEIVFVSGDEDEESFGDYFRKMPWLAVPFTDSETRDRLDELFKVRGIPNLVMVDDHGKLVNENGVGVIRSYGADAYPFTPEKMKEIKEDEDRARRGQTLRSVLVTPSRDFVISPDGNKVPVSELEGKTIGLLFSVASYRKCTELTPKLVEFYTKLKENKEDFEIVLISLEDDEESFNQDFKTKPWLALPFNDKSGSKLARHFMLSTLPTLVILGPDGKTRHSNVAEAIDDYGVLAYPFTPEKFQELKELEKAKVEAQTLESLLVSGDLNYVLGKDGAKVLVSDLVGKTILMYFSAHWCPPCRAFTPKLVEVYKQIKERNEAFELIFISSDRDQESFDEYYSQMPWLALPFGDPRKASLAKTFKVGGIPMLAALGPTGQTVTKEARDLVVAHGADAYPFTEERLKEIEAKYDEIAKDWPKKVKHVLHEEHELELTRVQVYTCDKCEEEGTIWSYHCDECDFDLHAKCALNEDTKENGDEAVKVGGDESKDGWVCEGNVCTKA
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MEQNRSTDKLQMEILKRTVCRLKPSAHRCLLAGSHSFTQLVLCLILSATLVSCNRAPVFLIDDHAEIVIRLREFPETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELDREAREEYTLILTLTDGRLGEGNFVTQSFLLLVEDINDNEPIFKPFASVLEVAEDSPPGILTTLEAVDKDEGAYGQVVYYIQGLSEENNVFSISTSNGKGVVRLARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEFLVTQPVVRISEDAPIGTEVMRVKAVDGDRGINNRIIYGISNNGSELFEIDRLKGSLRTKQKLDREDSTNPINGAFILEVVAIEESKLQPAPSSTMEITVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHPPSDIFEVIPKRAINEATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPVYEIDVPENVTAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVTLMASESPVFDREIIQKHYLSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRLIGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPVFLESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPDALGSGSTYVLEVFATDGGNGDQQLQGSCLVNVTITDVNNKPPYFVGPTAVAVRENTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKLDDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPFYKHSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYSWLNFSVRAADTGTPPRASFVEVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEIAIILAKDLDSGDFGRITYILDRVSSKEKFSIDPEKGILRVAGALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVIQKPSGCSMITEYHNINDPIVKLRATDADDPTNGNGQLSFDIVDPSGIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLGGVPNTARETVDICVTDFNDHAPVFVVPSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSLDKETGELSLAASLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLKEISLNFTEHMTPGTERIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKKSLYKLHIKATEECTNANLSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTGGISTSSLFGATILQLQATDEDDGLNGLVRYYRHGEVRKTLAEGLDDLRSDPFLVEADTGQVLLNFFPQKSMRGYFDFSVLANDSYGCHDRAHVFIYLIREDQRVKFILRQRPSEIRHNIQSFREILSNVSGCIVNIDDIRVHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLDTHVEKLDRLFKEFNVLDTQASELVQTAEMDELSVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGPSRMYQEVLGAVPNTNKHSMKGSNPIWIGSGTPEGEWAKDEFDKCKDAIDAQYERSLSSGFFIDNCLQYEARKGFAGAEANNAANYQLKRDSETTLCARNLETTEL
The following text describes a protein:
Function:
Probable nucleoside permease that transports adenosine and guanosine.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MLFLKLVASVLALMTIVPAQAGLIGKRSVFKPKVMIINMFSLEANAWLSQMDDLYANNITVVGLNRLYPQVHCNTQQTICQMTTGEGKSNAASSIMALTLSPKFDLTETFFLISGIAGINPYAASLGSVGVARFAVDIDLINSVDLRELPSYFQSSGWEIDTDPYENGSSNEIVYPESMPYQTNLYELNNTLITAAMEIIKDVVLEDNEKAASYRKLYNESAARRPPFITQCDTATGDNYWAGTYMGDFVSNITNVLTNSTGHYCTTQQEDNASLTALTRASFDGLVNINRVVIMRSGSDFDRGAGNITALANLLNSTGHVSSLACDNLYHAGAPLIDHIVNHWSYWT
The following text describes a protein:
Function:
This enzyme acetylates the N-terminal serine of ribosomal protein bL12, converting it into the acetylated form of bL12 known as bL7.
Subcellular Localization:
Cytoplasm.
Sequence:
MTETIKVSESLELHAVAENHVKPLYQLICKNKTWLQQSLNWPQFVQSEEDTRKTVQGNVMLHQRGYAKMFMIFKEDELIGVISFNRIEPLNKTAEIGYWLDESHQGQGIISQALQALIHHYAQSGELRRFVIKCRVDNPQSNQVALRNGFILEGCLKQAEFLNDAYDDVNLYARIIDSQ
The following text describes a protein:
Function:
Imidazole glycerol-phosphate dehydratase required for histidine biosynthesis.
Sequence:
MSERIASVERTTSETHISCTIDLDHIPGVTEQKINVSTGIGFLDHMFTALAKHGGMSLQLQCKGDLHIDDHHTAEDCALALGEAFKKALGERKGIKRYGYAYAPLDESLSRAVIDISSRPYFMCHLPFTREKVGDLSTEMVSHLLQSFAFAAGVTLHIDSIRGENNHHIAESAFKALALAIRMAISRTGGDDVPSTKGVLAL
The following text describes a protein:
Function:
Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.
Subcellular Localization:
Secreted.
Sequence:
MLITNPALLGILASLVPLALGAPNQPIQARSRKCVIPSSYASSHGTADDSPAVASAFAQCAENSVIVFQEGVDYNIFHPIKATNLSNVEIRVLGNLHLPQDITAVQNIVKSGQSTWFTFQGPRVDWTGADDIKNGWINSYGQAWWDANPANSSSFPNRPHLMSYKTSQASIKNFRSRKPIAWNVKLQGDDITVSHAIVDATSTGGFPFNTDGFDVEGTNISITDSVMFNGDDAIAVNTPSHNIVFARNTIGYQSHGMSIGSLGKDPTDFANITNLRFEDVTVIDALYAARFKSWSGGRGLVKNVVWKNIRTFNVTFPIFVTQSYSDQSASRSGTIDPFSSVMMEDFTWSDFSGTINTYHPGDGSCVTDPCWYNVGLPNLKHTEAIVLECNTESSCKNFRTEGIRLHPQSKDSPSVICMKATAELNPKLGFECKNGTFVPH
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MTHSGERPYACTVCDVTFSQKGTRDRHERTHTGERPYTCTECDATFAQGGDLRRHNMTHTGERPYACTECDATFARGGALRRHNRTHTGERPYVCTQCDATFAHGEGLWSHQRMHSGKRPYACIECDAKFARGSDLRSHQRTHTGERPYACTECDATFAQGGGLQIHRRTHTGERPYACIECGAAFVTSDNQKKHFRDYHTAEGQQRRKREEERVAKLLEGASIDFKREHAVSFRCILDTFARVDFIIILNGKVIVLEVDEYQHDGYGVACDVSRMIKLYGAWLLEGNTLPVRFLRYNPHLFRVDGKQKKLKRVVREDRLLRAIREASEAEGDGMRVWYLYYDVVAGKPAIMQDPAFTIEHLATAQIDQRYGPRTTAPYALKIKQNHFVDAACKRGIGSIANAPRGTNKKTTAEYAINNVTSTMRLKATRPIYNGQEILVGYGSGYWAGHKGSHRTRRR
The following text describes a protein:
Function:
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Cell membrane. Secreted.
Sequence:
MFILLVLVTGVSAFTTPTVVHTGKVSESPITSEKPTVHGDNCQFRGREFKSELRLEGEPVVLRCPLAPHSDISSSSHSFLTWSKLDSSQLIPRDEPRMWVKGNILWILPAVQQDSGTYICTFRNASHCEQMSVELKVFKNTEASLPHVSYLQISALSTTGLLVCPDLKEFISSNADGKIQWYKGAILLDKGNKEFLSAGDPTRLLISNTSMDDAGYYRCVMTFTYNGQEYNITRNIELRVKGTTTEPIPVIISPLETIPASLGSRLIVPCKVFLGTGTSSNTIVWWLANSTFISAAYPRGRVTEGLHHQYSENDENYVEVSLIFDPVTREDLHTDFKCVASNPRSSQSLHTTVKEVSSTFSWSIALAPLSLIILVVGAIWMRRRCKRRAGKTYGLTKLRTDNQDFPSSPN
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.
Sequence:
MIKFFRKKRDKGIISQQLISETDFVVVDTELTGLNEFRDNIIAIGAIKMKGRTIKIGDIFYRTVSPSTKKFRKESIMIHEITPSELEKCPQIEPILREFIKFSKNCLVVGHCVDIDLTFLKKEIRNNLREIFEPFSIDTLLIYKWLIKKEILPSDFSNKNSLEDIALSLDIEPKELHDALSDAFITAQIFQRLLAYLGELKIFTVGELLEIGSIYEKSFGTTIKKEAYQL
The following text describes a protein:
Function:
Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MIKILRNINNNIVNRYDGLNKSYLNINFYCSTTNNSSGKIDYTKLIPENGNISKSITEKIGKNLHCKRDHPLNIIKKKIQYHFQNKLSDEEHKFQFFDSFEPKVSVKENFDELLFPVDHVGRSPNDTYYFSKDQLLRTHTSAHQSQLLREQEKAFLVTGDVYRRDTIDAVHYPVFHQMEGVKVFKDKVNLAIDGKPFDETIDYYEDNNYKQLQSVKDVEKDLKQSLESMIRSVIGQDLQVRWIDAYFPFTSPSFEMEIYFQGQWLEVLGCGVVHPSIMNNCGLSNDRAWAFGIGLERLAMILFNIPDIRLFWTEDNRFHNQFKGVDKSISTSSSSSSSSSSSSSSTLSDIDIKGVQFQQFSKYPSCFKDVSFWLEDEENFHENKFYEFVRESCGDLVERVDLVDNFTNKKLNKTSHCYRIYYRSMDRNLTNEEIDILQFNLREKLENHLSVKLR
The following text describes a protein:
Function:
Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence 5'-CCAAT-3'. HAP4 encodes a regulatory subunit of the DNA-bound complex and seems to provide the principal transcriptional activation domains. Does not bind DNA directly, but augments the binding of HAP2 and HAP3.
Subcellular Localization:
Nucleus.
Sequence:
MTAKTFLLQASASRPRSNHFKNEHNNIPLAPVPIAPNTNHHNNSSLEFENDGSKKKKKSSLVVRTSKHWVLPPRPRPGRRSSSHNTLPANNTNNILNVGPNSRNSSNNNNNNNIISNRKQASKEKRKIPRHIQTIDEKLINDSNYLAFLKFDDLENEKFHSSASSISSPSYSSPSFSSYRNRKKSEFMDDESCTDVETIAAHNSLLTKNHHIDSSSNVHAPPTKKSKLNDFDLLSLSSTSSSATPVPQLTKDLNMNLNFHKIPHKASFPDSPADFSPADSVSLIRNHSLPTNLQVKDKIEDLNEIKFFNDFEKLEFFNKYAKVNTNNDVNENNDLWNSYLQSMDDTTGKNSGNYQQVDNDDNMSLLNLPILEETVSSGQDDKVEPDEEDIWNYLPSSSSQQEDSSRALKKNTNSEKANIQAKNDETYLFLQDQDESADSHHHDELGSEITLADNKFSYLPPTLEELMEEQDCNNGRSFKNFMFSNDTGIDGSAGTDDDYTKVLKSKKISTSKSNANLYDLNDNNNDATATNELDQSSFIDDLDEDVDFLKVQVF
The following text describes a protein:
Function:
The heterodimer with SLC3A2 functions as a sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, histidine, methionine, valine and alanine (By similarity). The heterodimer with SLC3A2 mediates the uptake of leucine, isoleucine and tryptophan. Functions as an amino acid exchanger (By similarity). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (By similarity). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (Probable). Can mediate the transport of thyroid hormones diiodothyronine (T2), triiodothyronine (T3) and thyroxine (T4) across the cell membrane. When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (By similarity).
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note=Located to the plasma membrane by SLC3A2/4F2hc. Localized to the apical membrane of placental syncytiotrophoblastic cells. Recruited to lysosomes by LAPTM4B (By similarity). Expressed in both luminal and abluminal membranes of brain capillary endothelial cells.
Sequence:
MAVAGAKRRAVAAPATTAAEEERQAREKMLEARRGDGADPEGEGVTLQRNITLINGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLSLVVWAVCGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPVFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFIQMGKDIGQGDASNLHQKLSFEGTNLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTNQMLTSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLMYAFSRDIFSIINFFSFFNWLCVALAIIGMMWLRFKKPELERPIKVNLALPVFFILACLFLIAVSFWKTPLECGIGFAIILSGLPVYFFGVWWKNKPKWILQVIFSVTVLCQKLMQVVPQET
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MDHIFTINKKINKSVDTSKHLSFTKLEKSTLCSISSSNVVAFSTECNIEEAGSLFWNSNVYVCDLNSPWQVHKILSNSSPISVLQWDFTGDLLLVADENGSIKIYKAKDHILNDWTLVLQTVLEGEHILSAAFFHSGKKICLNSEKKDSALYTEKFHHVKFACSVKQFGGRPASGALLLTTTGMLCSILLPQSTSQVAMVMATESLAPTRIFIKAADICYGKNGHFLLAVSNGDLSMPIQCYKVSVRKAEDKCVITSQSLLSFFLFEAPKEALMEQVSKEKNCHISHIKWIMREDADSVVVSATSDKISCLQVWELREKALPVHKSLGKSETPQFFNTVLWQYQCHFQYNSRVTSLATSKLSLLNNVSSGYVVATFADNSIHCLYRDTLKHLVSTTLTICPRYFDEPLARYPKTSIKISNIDMSWLGNILLVIDSDDSLHMFKLPPQIDSSTPLSVPYCTTILEYCMMSGFDWLDLLLVLRPGMLDAICDRLTESFNRQPSAVQQFFYVQYLCMKISLCRLSVQGQVKAHDLAQFLMLHSISTAFKSLLRPSEMSSHDKSPADSLANVIAEGQTDVDKVLMHLEAKEFTVEPSTLQSLQQLIQWVADLALNLLVKLPDSRPSMGKVYELLRDVKALNMLREMLVLIRIWGLLRPACLPVFIKSDGSLDVLALLFRLLSRLVQNVNEPDDTLIDECCLLPSQVQIQLFQPSNNRAVLASPQLVQQILPLQLEYNNDPECLMSSTDSGATQTVDSIRHLYLGRTPRAIKQCVRCGGSAGTIPVTRTAAIRAWDQRWLRSCQCGGLWRMQVYT
The following text describes a protein:
Function:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Subcellular Localization:
Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
Sequence:
MCCEKWSRVAEMFLFVEDLEEDAGILCLCSRAFVEDRKLCNLGLKGYYVKGNGDNAGDHATEEEEGGTAESHDSKGLGLDENELDSEAELMRSMGLPLQFGGISAHKNFEVSMNTRNKVKIKKKKKKHQKKYLDEIMRESWRQDYEEDDILASDDPSSVEQYESTKTCKLKTKEDIETENLPVENTLSPKLEITERWEKYWNEYGGGLLWQSWQEKHSGQTLCSEPWNIPDTKEEWEQHYSQLYWYYLEQFQYWEAQGWTFDVSQTCETDTCGSKIEVDSEKDENCMKADLLSFPSPSVTIDSESSSSSDKEHNEILGGISHISLNSEEVEQSQLDSSVSCDGHQWLSEVSSSRECPASGQSEPCNRGTKDSNLSGNRSTNQPAPDSQDSSEASTIKERLHPNSIDGDESEEDPPERKPSKLKRSHELDIDENPDSDFDDNGSLLGFKHGSGQKYGGISNFSHRRVRYLQKNVKYKSKFLDMRRQINMKNKHIFFTEESEKTFKKSKTLTKVEKFLKWINEPMDEEASQESISHDNVQDTCTSSDSEEPEMSVKEGDDPLQTNNPEPEKCNATSSAGELETEKNEGDSTIVIITDKEDGITQITPDSLQVETEAESKKKKKKKKNKSKKVIGLPPEIAAVPELAKYWAQRYRLFSRFDDGIKLDREGWFSVTPEKIAEHIAGRVSQSFKCDIVVDAFCGVGGNTIQFALTGKRVIAIDIDPVKIDLARNNAEVYGIADKIEFICGDFLLLASHLKADVVFLSPPWGGPDYATAETFDIRTMMSPDGFEIFRLSQKITNNIVYFLPRNADIDQVASLAGPGGQVEIEQNFLNNKLKTITAYFGDLIRRSAPES
The following text describes a protein:
Function:
Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8B, together with C8A and C8G, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity.
Subcellular Localization:
Secreted. Target cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells.
Sequence:
MKTGAQVWRALAKSCLLCAALGCLHLPGARGEKPDFFETNAVNGSLVRSRPVRSVDVTPAPTDCQLSTWSSWTACDPCQKKRYRHTYLLRPSQFYGELCDFSDKEVEDCVTNRACRSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKCSQDMEQYWAIGNLASGINLFTNTFEGPVLDHRYYAGACSPHYILNTNFRKPYNVESYTPQTQGKYEFALTEYESYFDFEHNVTEKATSKSSFKFGFKLDGLVEFGVRKESNEGRHYISRTKRFSHTKSKFLHARSVLEVAHYKLKSRQLMLHYEFLQRVKSLPLEYSYGEYRDLLRDFGTHFITEAVLGGIYEYTLIMNKDAMERGDYTLDHVSACAGGGFQIGGNVYKVYLKLGVSEKKCSDILNEIKDRNKRRTMVEDLVVLVRGGTSEYITSLAYKDLPTAELMKEWGDAVQYNPAIIKLKAEPLYELVTATDFAYSSTVKQNMKKALEEFQMEVSSCRCAPCRNNGVPILKESRCECICPAGFQGVACEVTNRKDIPIDGKWSCWSDWSPCSGGRKTRQRQCNNPAPQRGGSPCSGPASETLDC
The following text describes a protein:
Function:
Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells.
Subcellular Localization:
Lysosome.
Sequence:
MLVLSPSPLARARSSPAPDARARALSPISPQSVFPFLFLPSPLRGPDFWRVACFYAQSGRKKWKGGRRAGPPAEGAGLRRIGGVSAHAWPGRGRIRPASSPFPRIRDTTSPQSSSTMVILLLLAAMLPGAATVISCYGDTGKPVDWFAVYKLPELPDSRARSGMSYMYLDGKTEGWREGTGLINSTQGAVGRTLQPLYRGNASQCDGLAFLLYNDQPPKGSGVKDKASRGHTKGVLLLDKDGGFWMIHSTPHFPPPASTTYSWPDTARPKGQSFLCVSFSYSQFQEIGKQLAYTFPLVYNYSVEGTFAQDLPELLAASQGHHVKSAPWNRSVALTSSSGEVFFSFAKFGAFADDLYSGWLASALGSDLDVQFWPNSPGVLPSNCSGPFRVLNVVHTAFPPPAGPTFSATLDHSKWCVAARGPWTCVGDMNRNQGEEHRGGGILCSRLPALWKAFQPLVCPPTSLCCLVAPPRSPQSG
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MVDNSTTNNNGQQLIPGQDLPRRGGSQVADHDGHGSMLPTEAWPVLTATGYILVAVAGPGVLSMAWNLAQLGWIAGPAAIILLSFLTWIASIILCDFYFSPHDPDKRNPSYMHVIRSYLGAGRTANVKICWVIQYLNLFVIASLYTDSASQMMADIEWVSKCSNSNNVNVDDSIKIPCWVYQKPYYIVFGVTQILLSQISDFRRLRWLTLLCFGAFLIFSSIGVGLSFTKIASDKWSIKGSLEPQGNINMTRAKKTWLIFKALGHIADGFDFSSVLLEIEDTIGGGLPAQEAQKIMRKAIHYGLPAATCVYLFFGSLGYAALGEDSPEYIFLYGFYKPHWLLNIATAAMVLHYAGAYQLFIQPIFAMFEKAVVKRFSPDNEFIKRKIKIWTYEFKLFQLVLRTFFVIVTTLLSMFLAIYLDILELIKILAFWPIVFYFPVKIYIMEKKIPMWSARGLGLQMMSFGILIVTMAVAAANIVDVFLQDSYNPIMPNRYY