lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the recognition of invading microorganisms. Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MRWEFLPCLLLLISNNKIFGFKVPSINFEMLKDEGFEVSIPDEPGIQRVFYMFQIDDTCPALMDYITEAVNGSWVSKQKMSLQNNDKLQISMLVQFNEEIFEKSETRVIINTRLLTTKDSSSRGITFLTGEGECQAYLAPAQQAKRCKAAQTIVSNGRHTCQGELIFEDNFSEAQLNKTTWKHDIRQRMYHVEEELVAFDDAARNCFVKEGELHIVPTIATEVTDGSFKLGDRCTAVESPEQECNIAHGIFYSIKPPVFSAQIHTRNSFSFKFGKIVVRAKLPKGDWLFPYLMLQPVSTYAETHYAKQLRIAYARGNANLRTKQGDDISGNHLYGGGVVWHHGNAVQFLKDKISNSHYGDDFHNYTMIWQRDKITLMVDDEVYGELYDGLPFFNEKCFIIFGVTVGGFLNFDDSLLAKDVKPYKNREPRAALSFWQHRDAWAPTWGRHSAMVIDYVRVYAE
The following text describes a protein:
Function:
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEPIPPSNGNKNNSMDKQPQQPQQPQQQQQQQQQQRRDQRNSKLNELNETERVRNRFISHEFHKLDRTKSRIDAPKISFSDSESESDSEFFLAKRNTNNNNQNNTSPTFSSANGKQSNLTQRKINTQIQSKQPTNNNVQPLTDDEGTINHSNHHHHHHNQNNNGNNNNNNNNNNNNNKISTPPKQEEKMTMNGLFTLRPSILSSESNGSSYRGFLNLLLILLITASFRLVILNHLLYGIRINLDLYKISEYHRWPGVMISLMINLFIIAAYLIEKAAAKQLLPDRICYLLRIINCAAVIIVPSGSIIAFSPNPASGIIVMILICTFSMKIISYAYENSKQRKLNPDNKKFVIDPTNTSIYPNNLSLRSTYWFMLVPTLVYQLSYPRSPKIRKGYLLRRIVEALSLSLLILWMVNQYMLPLVQNSIEPLEKIDIVLIVERIMKLSLPNLYVWLLGFYVFFHLYLNIVAEITRFGDREFYRDWWNSTGLDYFWRTWNMPVHHWMVVLIYTPMRRRGFSKNMGYFMCFFVSAIFHELVISIPFHSLKLWGFFGIMSQMVLIALTKNLMNGRNLGNVIFWISIVLGQPLVVLLYYRNFVLENPEWYRNVEPPTSPPVMPFY
The following text describes a protein:
Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MAGHKVAHATLKGPSVVKELFIGLALGLAAGGLWKMHHWNEQRKTRTFYDLLERGEISVVAAEE
The following text describes a protein:
Function:
Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines.
Subcellular Localization:
Nucleus.
Sequence:
MQKPCKENEGKPKCSVPKREEKRPYGEFERQQTEGNFRQRLLQSLEEFKEDIDYRHFKDEEMTREGDEMERCLEEIRGLRKKFRALHSNHRHSRDRPYPI
The following text describes a protein:
Function:
Probably part of an ABC transporter complex. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRPLDPVTSRQRVAFGLAFFVLFVALWSWATFGGHVSKTFLANPLTMVQEGFDLLTKQGFMFDIGMTIWRVVGGFALAAIIAVPFGVLMGAYKPVEAFLEPFVSFARYLPASAFIPLLILWAGIGELQKLLVIFIGSVFQVILMVAVTVGATRRDLVEAAYTLGASDRGIIRRVLLPSSAPEIAEILRLVLGWAWTYVIVAELIGSSSGIGHMITDSQALLNTGQIIFGIIVIGLIGLVSDFLFKAFNAWLFPWKLA
The following text describes a protein:
Function:
Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MHHAMARVFETFKDSKYAIFIDEGFRARPGFLRYFGQTLSLLDQDDSVFSVSAWNHNGFEGLSQDPSLVYRTEDFPATGWVVRRSVWESEVRGKEAACCMVFPWHSWFGGDLKGREVLVPDVSRVEYIVREGLFEDDAFRQDYFPGRSSNSEPVQDVSDVQKLSRDVYEEEVKRLISSSTPLQPSQFSTCLTQQEHFAGPAEKGKVFTVYFEQENPTDRRVLQKLAGCFHLFRQEGDVRRLHKNMLRYLHFSKKTAPRTCSAADDHRVEY
The following text describes a protein:
Function:
Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the intermediate formylmethanofuran (formyl-MFR). Catalyzes the transfer of a formyl group from 5-formyl-H(4)MPT to MFR to produce tetrahydromethanopterin (H(4)MPT) and formyl-MFR, which is then hydrolyzed to formate and MFR.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDFTLNGIKVEDTFAEAFDVAGTAIIVTNDTPKWAMIAATVMTGFATSVIGCGAEAGIDAELSPDETPDGRPGVRILLFGFEPNGLKDQLLKRVGQCILTCPGTACFAGVEGPTKIKLGGAIRYFGDGFAVAKRLPDHEGKMRRYWRIPVMDGEFLCEDSVRAVDGAVGGGNLLFLGRKHADTLIVAEIAVEAAKAIPGAILPFPGGIVRSGSKVGGRTKGMMASTNDAYCPTLKGRAGSALPPECGVVLEIVIDALTSAAVAESMRAALHAATEIGAQHGLVAVTAGNYGGNLGRHHYHLRDLLEKPAA
The following text describes a protein:
Function:
May be involved in constriction of the cell inner membrane to form mature magnetosomes. Binds cardiolipin and liposomes (By similarity). May function with MamX, MamZ amd Mms6 in biomineralization (Probable).
Miscellaneous:
MISCELLANEOUS: This bacteria makes up to 60 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)).
Subcellular Localization:
Magnetosome membrane; Multi-pass membrane protein.
Sequence:
MLMNFVNNVSKTINGGARIVYVGSFSWAVLSLLFVTAFSGWNNIFSMLPHEIFILVLTISLPIALIVLIFMLSQIVRTVESVKSEISTLSQRDPVSEEAVTMLADLFREHRDAVAAQVAAQVEATAQLVQINQDNRALAAPSPDSGDENPLALLAQMFREYRETVTAQLEAQISATTQLVEASRDSRDGIVDELRSQRVLSQEITQELSHIAQSRNVVPVAEPGLDPSQRIDRMRALAEVLGLALNDLSMTATQLLSEHLNAAHGDREGTQKFISTLTNAYFAGDKNVFFRSLVSEVVNHSDQLQQCAIGAENVRQQISKILREAREIRSLVSACDPNDLVRIVFEDGELWALEKALAEHFLIDGTPISDA
The following text describes a protein:
Function:
Component of the transition zone in primary cilia. Required for ciliogenesis.
Subcellular Localization:
Cell projection, cilium. Membrane; Multi-pass membrane protein.
Sequence:
MADDNSNSRQRKKIRKPQSSAIQMIDTTETKKTRKKRALQEDTDDVTKDPKATTNSRRKKNVEEKRAKLVERETAFASDHDDQEKIVPKSIKKKKKRTTGQQMADNSYMESGSRASVQADDHENKDGLKMNDSFGNPDVVDGDTTKNEERSRKKKGKKRKDYQLTSAAAVSHYSEADFDHDLNLSPEDVITSKDYNIEITEPPNLVPSLPSQPLNVVYVERTDGGGFRRVNKSNLNDMKKDKDIDALKSKMSNITNSAQLGSSVFNIFMKIAFFCEGLLAGFALWQTISISTIENQVNGTITVLACYNRLSQAAQSVYYFLLAIATVSVMDRFDLESHEYVSLITRFIRHPVLALCILIHILSLILSTSIAEIDYRIGLYNVNQSFYWPTVTDQNVRRLTTQSQTLFSSWRIINLLRGILAIAGWMLVSFNPITAIPEKYLYGRKNDILGEDIDV
The following text describes a protein:
Function:
Transcription factor required for female gametophyte fertility. Acts redundantly with MYB119 to initiate the FG5 transition during female gametophyte development. The FG5 transition represents the switch between free nuclear divisions and cellularization-differentiation in female gametophyte, and occurs during developmental stage FG5.
Miscellaneous:
MISCELLANEOUS: The gain-of-function mutant upd10-D (T-DNA tagging) is infertile.
Subcellular Localization:
Nucleus.
Sequence:
MEEQKIQEKSLAHGAAPPLTAVERFLNGQKNEALCFKKQERSIDRPIVKTTRAIEIRNENKENMMFGPRKEKNLAVIGEIVVKGAAKDYTCKDITKKQPYKNIIKGQWTADEDRKLIKLVMQHGERKWAVISEKLEGRAGKQCRERWHNHLRPDIKKDSWSEEEERLLVEAHTRIGNKWAEIAKLIQGRTENSIKNHWNATKRRQNSKRKHKRSKNADSNSDIDDLSPSAKRPRILEDYIKNIENNDKNNGENIMTTSGNNVLSTSNYDQFNSEDSTSSLLDDPYDEELVFLKNIFENHSLENINLSQGTEITQSSSSGFMIENPKPKPNLYNNTFGTHLGAMVTEPANSSHLASDIYLSDLLNGTASSSSSLTFLSSNNNEHAGENELLLPQANSTSERREMDLIEMLSGSTQGSNIWFPLF
The following text describes a protein:
Function:
Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
Sequence:
MNQPASAYFIEDRHDPNETHTLSVLVQNEPGVLARVIGLFSGRGYNIESLTVSETEAQKHLSRITIVTTGTPMVIEQIKHQLDRMIPVYRVVDMTQTKRSIERELAMVKVRGQGEHRVEALRLADAFRARVIDATTESFVFEITGNTDKINQYIDLMRPLGLVEVSRTGVAAIGRGPEGM
The following text describes a protein:
Function:
Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and also functions as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MCPLRSLLLISTLVLLHHLPHLSLGRSLPTTTASPGRSCLDYSQNLLRAVSNTLQKARQTLEFYSCTSEEIDHEDITKDKTSTVEACLPLELATNESCLASRETSFITNGHCLASGKTSFMTTLCLRSIYEDLKMYHVEFQAMNAKLLMDPKRQIFLDQNMLAAIAELMQALNFDSETVPQKPSLKELDFYKTKVKLCILLHAFRIRAVTIDRMMSYLSSS
The following text describes a protein:
Function:
Mediates influx of magnesium ions.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MIRICAVTKTDEVLYDVSLEETKKDHIVWYWLDLYKPTKEEYTYILQDHFKFHPLAIEDCLEYVQRPKVDFYDGYNFLVLHAFGEDGLEPHEIDLFVSDRYIVSFHFSHNNAIERVWKTLGEKRRIKKGPLHVAHTITDQIVDDYFAPVYYIEDHLNAIDDNLTGETAGAVLEEVFDIRADLSKLRRTIIPMRDLLYRILNSTRFYGISDHEIYFKDIHDHLLKLTEMIEASRELTADIRDSYFSLNSHHMNNIMKTLPVFSTIFMPLTFIAGVYGMNFTHMPELGGQYSYFICLLLMALIGGGMMAWFYKKGWFK
The following text describes a protein:
Function:
Binds anionic lipids and gangliosides at acidic pH.
Sequence:
MGVYPNSTYAGSFILGSLNAPGTGVVVQEWYHKTAEGGYWIQLFTEHGCIPVQTLMFGKNSAGNEVHYHHDYMDVTLGVKDRAIFDVPKECL
The following text describes a protein:
Function:
Golgi matrix protein playing a role in tethering of vesicles to Golgi membranes and in maintaining the overall structure of the Golgi apparatus.
Subcellular Localization:
Golgi apparatus. Note=Locates to the trans-Golgi or to the trans-Golgi network (TGN).
Domain:
The C-terminal GRIP domain (711-788) is necessary and sufficient for Golgi targeting.
Sequence:
MSEDKESDVVGEEEESHVIKEDKELNDASNETLTENGDQLLQMIAELRLENDFLRSQFEGLKDEVAQGRSLQKAEQVEADSAQLKQLQEQVASLSREIDVEKQTRVAAEQALEHLREAYSEADAKSQEYSSKFSQVEQKLDQEIKERDEKYADLDAKFTRLHKRAKQRIQEIQKEKDDLDARFREVNETAERASSQHSSMQQELERTRQQANEALKAMDAERQQLRSANNKLRDTIEELRGSLQPKENKIETLQQSLLDKDQILEDLKKQLQAVEERKQIAVTELSAKHQKNLEGLEAQVVDALSERDKAAETISSLQVLLAEKESKIAEMEAAATGEAARLRAAAETLKGELAHLKSENEKEKETWEASCDALKSKLEIAESNYLQAEIEVAKMRSQLGSEMSMQTQILSTKDAELKGAREEINRLQSEFSSYKIRAHALLQKKDMELAAAKDSEQIKSLEEALKEAEKEVYLVSAERDRAQQDLQSALASLEKELEERAGALKDASEQIKSLEVKLDSTVARNQAEKQAWEEDLRVLEETWRRRCEALTAQNEASPAEGIEKELENAKLRNKRMKEEHESVRELADRLIEEKDREISRLVDEMTNLRKSMESKPVWNKSPSQVHHYGNNNTESQQQDVSNLSTSAAEHQILILARQQAQREEELAQTQRHILALQEEIEELERENRLHSQQEAVLKTELREMERKQKREGVDMTYLKNVILKLLETGEVEALLPVVGMLLQFSPEEIQKCQQAYHSSTTAATTTEATPSPASEGSGLSVFSRFSFS
The following text describes a protein:
Function:
ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular Localization:
Nucleus.
Domain:
The DBINO region is involved in binding to DNA.
Sequence:
MASQLGAGDDGCCPELAKPLYLQYLERALRLDQFLRQTSAVFNRSISSDDSEDGLDDNPLLPRSGDPLIQVKEEPPSSLLGEPSAAGRSGPLNAYSLNGVLQPEPRSEKANLYNFSKLKKSRKWLKGILLSDESSDPEDSQSEEEREEEEEELSLSREELHNMLRLHKYKKLHQSKYSKDKELQQYHYYSAGLLSTHDPFYEQQRHPLGPKKKKFKEDKKLKTKLKKVKKKRRREEEVSSEESPRRHHHHQTKVFAKFSHDAPPPGSKKKHLSVEQLSARRRKVWLSIVKKELPKVSPPRPRNLFLTNSRKGKLAHQCMREVRRAASQARRNCKETLPRARRLTKEMLLYWKKYEKVEKEHRKRAEKEALEQRKLDEEMREAKRQQRKLNFLITQTELYAHFMSRKRAAGPDGLQDEILRQLEDSSAQRQIDIGGGVVVNITQEDYDSNYYKAQALKNAEDAYQIHQARTRSFDEDAKESRAAALRAADRSGTGFGESYKPGPTRPSGPARTSPSPTIFNGKLKGYQLKGMNWLANLYEQGINGILADEMGLGKTVQSIALLAHLAERENIWGPFLIISPASTLNNWHQEFARFVPRFKVLPYWGNPHDRKVIRKFWSQVTEYAPFHVVITSYQLVVQDVKYFQRVKWQYMVLDEAQALKSSSSVRWKILLQFQVSERLLLTGNAIQNTMAELWALLHFIMPTLFDSHEEFNEWFSKDIESHAENKSAIDENQLSRLHMILKPFMLRRIKKDVENELSDKIEILMYCQLTSRQKLLYQALKNKISIEDLLQSSTGSAQQAQNTTSSLMNLVMQFRKVCNHPELFERQETWSPFHISLKPYQMSKFIYRHGQIRVFNHSRDRWLRVLLSPFAPDHIQQSLFHRKGDNKESCFSFLRFIDVSPAEMANLMLRGLLARWLALFLSLKASYRLHQLRSWGEPLGESRQRSLGLRNKDFLLGVDFPLSFPNLRSCTLLQSLVFSGHCKAASGYSDQVIRRRRSAAVSVRPCQFTELPSFLCVASPRVTAGPLESYCDDRSAEFERRVLREGGSLAAKQCLLNGAPELAADWPDRRYQFFPAAPGGLWSIRPRNGWSFIRIPGKESLITDSGKLYALDVLLTRLKAQGHRVLIYSQMTRMIDLLEVGGPAYGAGVRPDRRGDGPGRRPRRRARRRRSVGRRCLLSAYRVRSTGRSAWGSEIR
The following text describes a protein:
Function:
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MRHVFLPWAAAAVLLLGRANASGKTKPGSALQLQVINFNFETVQVTWNSSAYAGINFTFIYKFHTKEEYRPCPDYILQHGYRAGCLLEVQRDGPLYFSIRNGTEPLLTKDLAISTYLKPRSPGALNFQWREEAVTVTCSSLGYNDLQYEIQHKTVFDAEWQSTEAETCNVTIDGLDTEKCYFFRARVKALEFAYGSETYPSDWSEVTYQQRGELRDSCWENSLFPKFILIAGMVSFLTVFLLLLSLWKLHRIKKVLMPSVPDPKFSFLGLFESHQGNFQVSSISLCKLQRDSAIHVSILPQLPSHPGCHVTLSRVPCAGQQVLAGSPC
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MRELDAQSQDLQRRIEDTLAARIAELRERAEGGSPKEGSVTPGKDAHGKERQIEKDHDACAQLADKKVALAEQTYNLIDKHIRRLDTDLHRLQAEVKAERAAAAATAAAANPPLQEQPKTSPRDSNGDAHTPGGTQRKRGHVATGAPPVVPEAPEPPPVEINLEIDPNEPTYCYCQQVSFGEMVGCDNKDCEIQWFHFDCVGLTTKPRGKWYCPDCITKVKRKRTK
The following text describes a protein:
Function:
Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MRTAQSGDIVFIHYIGTLDNGRIFDSTTDEAPLRFTIGKNEIFPALERQIIGMRPGEARNILIAAADAYGPRRAENMLTLGRDSFPADRPISVGQKLRLEFNGSAERVMLVVEVTDAHVVLDGNHPLAGCDLTFALRLDGIENA
The following text describes a protein:
Function:
Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing.
Subcellular Localization:
Cell projection, kinocilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus.
Sequence:
MAAESGELIGACEFMKDRLYFATLRNRPKSTINIHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKKLKSYSLSRKKIVHYTSFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTVLDCLQGIRKGLQHGFFDFETFDADEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKNNVTTIVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNRPSSEGSITKIISSLDDMSIAGNLSKLQSTERIGENNFEDEDMEIKNNVTQGDKLRALKSQRQPRSSPSCAFRSDDMKGHQRAVAQTFRLSSSPQPTVPTVKTPKVCLSPSVTAKRISRGSLSSGANIRSFSINSRLASSLGNLNSGTEETENKKTTSPIKAAFIASPFTSFLNGSTQTPGRNYPELNNNQYTRSSNSSSGGSLGGNLNSSPSAKPEEHNTILRPSFSGALSSSSVRFLSRSIPVSSQTPPLSPQNPECNFCTLPSQPRLPPKKFNSAKETL
The following text describes a protein:
Function:
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Sequence:
MRKVFKLNKVKVKELLKKVESEYRRDAEIILSYLLKVSPSQIPLMYAREIPEEIVKRFFKQMKERKKGIPTAYVIGEWECMGRVFKVKKGVLVPRPETEILIERTLELIPQDREMVGFELGSGTGCISINLLIERPKLVMYATDVNPDAVELTKENAKLHKVDDRLFVFLGNAFEPVKGMKFDFIVSNPPYIPENFWEILPEEVKKEGYTSLIGGKKGWEFYELIAEEGTKHLKENGFIALEIGHDQGKVVKELLEKKCFKVNIFKDYAGFDRVVIAQRWS
The following text describes a protein:
Function:
Homeodomain protein that controls neuronal identity. As a transcriptional factor, regulates the expression of ftz, eve and en in a subset of neuroblast progeny and modulates the transcriptional activity of other homeodomain proteins such as Dfd. Required for proper neuronal differentiation, axonal outgrowth and pathfinding of most or all neurons and their precursors in central and peripheral nervous systems. Regulates asymmetric stem cell self-renewal together with brat.
Subcellular Localization:
Nucleus. Cytoplasm, cell cortex. Cytoplasm. Note=Dispersed in the cytoplasm of mitotic ganglion mother cells (GMCs) and neuroblast-like cell type.
Domain:
The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain.
Sequence:
MMSSEEYEADCFGLYSDENNVLLKANEPETTAATKQQHQPQFQQQQQQQQQQQQHHHQHQQPPPSSNGHTSPIPSQVNGDGSAANCGESGKTNTNTGSHSHSNSGNTNTDADKEQEREKAKEKANEEESEDSDDDVVVVLEGCEGNASSSSSSSNSNSNASSNNHKAAATTTTTATTANHCNRSGGSSRSHRSARSSRQISQSTAVGKTTTCAAKKPTAAQATTTTAKNSNSNSNVNVNVNVNSNGSGNGNANSKVNRRSRQRSLSKDINNQPASSNSNSNSSNNSSNSNGGATATAAGFMSSAAAAAAGAAGGGALFQPQSVSTANSSSSNNNNSSTPAALATHSPTSNSPVSGASSASSLLTAAFGNLFGGSSAKMLNELFGRQMKQAQDATSGLPQSLDNAMLAAAMETATSAELLIGSLNSTSKLLQQQHNNNSIAPANSTPMSNGTNASISPGSAHSSSHSHQGVSPKGSRRVSACSDRSLEAAAADVAGGSPPRAASVSSLNGGASSGEQHQSQLQHDLVAHHMLRNILQGKKELMQLDQELRTAMQQQQQQLQEKEQLHSKLNNNNNNNIAATANNNNNTTMESINLIDDSEMADIKIKSEPQTAPQPQQSPHGSSHSSRSGSGSGSHSSMASDGSLRRKSSDSLDSHGAQDDAQDEEDAAPTGQRSESRAPEEPQLPTKKESVDDMLDEVELLGLHSRGSDMDSLASPSHSDMMLLDKDDVLDEDDDDDCVEQKTSGSGCLKKPGMDLKRARVENIVSGMRCSPSSGLAQAGQLQVNGCKKRKLYQPQQHAMERYVAAAAGLNFGLNLQSMMLDQEDSESNELESPQIQQKRVEKNALKSQLRSMQEQLAEMQQKYVQLCSRMEQESECQELDQDQDVEQEQEPDNGSSDHIELSPSPTLTGDGDVSPNHKEETGQERPGSSSPSPSPLKPKTSLGESSDSGANMLSQMMSKMMSGKLHNPLVGVGHPALPQGFPPLLQHMGDMSHAAAMYQQFFFEQEARMAKEAAEQQQQQQQQQQQQQQQQQQEQQRRFEQEQQEQQRRKEEQQQQIQRQQQHLQQLQQQQMEQQHVATAAPRPQMHHPAPARLPTRMGGAAGHTALKSELSEKFQMLRANNNSSMMRMSGTDLEGLADVLKSEITTSLSALVDTIVTRFVHQRRLFSKQADSVTAAAEQLNKDLLLASQILDRKSPRTKVADRPQNGPTPATQSAAAMFQAPKTPQGMNPVAAAALYNSMTGPFCLPPDQQQQQQTAQQQQSAQQQQQSSQQTQQQLEQNEALSLVVTPKKKRHKVTDTRITPRTVSRILAQDGVVPPTGGPPSTPQQQQQQQQQQQQQQQQQQQQASNGGNSNATPAQSPTRSSGGAAYHPQPPPPPPPMMPVSLPTSVAIPNPSLHESKVFSPYSPFFNPHAAAGQATAAQLHQHHQQHHPHHQSMQLSSSPPGSLGALMDSRDSPPLPHPPSMLHPALLAAAHHGGSPDYKTCLRAVMDAQDRQSECNSADMQFDGMAPTISFYKQMQLKTEHQESLMAKHCESLTPLHSSTLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREFYYIQMEKYARQAVTEGIKTPDDLLIAGDSELYRVLNLHYNRNNHIEVPQNFRFVVESTLREFFRAIQGGKDTEQSWKKSIYKIISRMDDPVPEYFKSPNFLEQLE
The following text describes a protein:
Function:
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.
Sequence:
MEEGKYAKELDVAVRVVHMACSLCQRVQQKLVSSSDDGHVKSKDDDSPVTVADWSVQATVSLMLSETLVENLSIVAEEDVQTLTKADSEGLLAAVVNTVNECLAEAPKFGLQSPPGALGTSQILEAISRCSSNGGPAGRYWVLDPVDGTLGFVRGDQYAVALALIEDGKVVLGVLGCPNYPLKKELLNYPQNYNQTKSKTSLSTTATWEKGCVMYARRDGGGAWMQPLIHGDRMLEWPNSATQIWVSPIVDPALATVCEPVERANSNHSFTSGLAETVGLRTQPMRVHSMVKYAAIARGDAEIFMKFARAGYKEKIWDHAAGVIIIEEAGGVVTDAGGRPLDFSRGVFLENLDRGIIACSNAILHEKIVDAVYASWDSSNL
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MEQETFEEQEITVADINANVPQEVQNYLRSFNKAIQEKSLKEIEEHYEYKWRRTTDQYFKDSRWPEPVYIQAMFEQEGQEDSYFVSLYPELYYRDVYYRSSNTNIEITVEDRHASYDHYIELINMFVEPDAPLDLELPNKWLWDMIDEFLYQFQDFVIFRSRVDDAKTESDYQEIAERPNAWNVTIVLNALHSLILKSEINEQLEAYRSGQNPTEMAGAFGKSSLYKMLGCFSLVGLVRLQCHLGDYRQALQIMKNVDLDRRFIFSLVPACNVSLHYHLGFCYLMLRRYQDAFRLFESILIQMASHRGPGHYDGGRKRDTIVCLLALAYSLLPQRLERSVEHLMNEKEGENIRKIQSGEGADEAINHLLLRGAPRFLCPFLADPQQPPEEDVLKAESERQLELFKQEAKQLILLGQIRSYLKLYTRMKLEKLAKFLELTVPQLRSMLHSFKHKMSQIVHTPGGEPLAGERQFTDSVDFYVDGDEICIATMTVKKSYGDDFLTASLKMVTSNR
The following text describes a protein:
Function:
Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Activates NF-kappa-B signaling upon stimulation with lymphotoxin. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs; (Microbial infection) Plays a role in host defense against Zika virus infection.
Miscellaneous:
MISCELLANEOUS: Aedes aegypti lymphotoxin beta receptor inhibitor reduces dimerization and trimerization of LTBR induced by lymphotoxin (LTA(3)).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MRLPRASSPCGLAWGPLLLGLSGLLVASQPQLVPPYRIENQTCWDQDKEYYEPMHDVCCSRCPPGEFVFAVCSRSQDTVCKTCPHNSYNEHWNHLSTCQLCRPCDIVLGFEEVAPCTSDRKAECRCQPGMSCVYLDNECVHCEEERLVLCQPGTEAEVTDEIMDTDVNCVPCKPGHFQNTSSPRARCQPHTRCEIQGLVEAAPGTSYSDTICKNPPEPGAMLLLAILLSLVLFLLFTTVLACAWMRHPSLCRKLGTLLKRHPEGEESPPCPAPRADPHFPDLAEPLLPMSGDLSPSPAGPPTAPSLEEVVLQQQSPLVQARELEAEPGEHGQVAHGANGIHVTGGSVTVTGNIYIYNGPVLGGTRGPGDPPAPPEPPYPTPEEGAPGPSELSTPYQEDGKAWHLAETETLGCQDL
The following text describes a protein:
Function:
Oxysterol-binding protein that may be involved in the transport of sterols between the ER and the Golgi. Binds beta-sitosterol. Required for ovule fertilization.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus. Note=Interaction with PVA12 is necessary for targeting to the ER. Located in the Golgi in the absence of interaction with PVA12.
Sequence:
MASNDPKNGGGFFASLASSITNFGSAMSKSVNGLMGYEGLEVINPEGSTDDAEEEAGRGRWKQEERDGYWKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSYLLDMADKTEDPYMRMVYASSWAISVYYAYQRTWKPFNPILGETYEMTNHNGINFIAEQVCHHPPMSAGHAENEHFAYDCTSKLKTKFLGNSIDVYPVGRTRVTLKRDGVVLDLVPPLTKVHNLIFGRTWVDSPGEMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYNSAEEPKMLMTGKWNESLSYQPCDAEGEPLPGTELKEVWKVAEAPKNDKYQYTHFAHKINSFDTAPKKLLSSDSRLRPDRYALEMGDMSKSGFEKSSLEDRQRAEKKSREEKGQKFAPKWFDETEEVTPTPWGDLEVYQFNGKYSVHRATAENSEDTTDVKLTQFNPWQFQDLSA
The following text describes a protein:
Function:
Catalyzes the reduction of fumarate with reduced coenzyme M (CoM-S-H) and coenzyme B (CoB-S-H). In vitro, is able to reduces fumarate with reduced benzyl viologen, oxidize CoM-S-H and CoB-S-H to CoM-S-S-CoB with methylene blue, and reduce CoM-S-S-CoB with reduced benzyl viologen. The enzyme has specificity for the two thiol compounds as the CoB--CoM heterodisulfide reductase. The enzyme is very sensitive to oxygen.
Subcellular Localization:
Cytoplasm.
Sequence:
MESELYECDVLIIGSGGAGCRAAIEVSEHKLTPIIVSKGLSFKSGCTGMAEGGYNAAFACVDPEDSPDVHFEDTMRGGGFINDPRLVRILVDEAPDRLRDLEEYGALFDRQESGLLDQRPFGGQTYRRTCYHGDRTGHEMITALKEEVIRRDIETIDEVMITSLLVEDGSVLGAMGVSIMNSEPVAFRASSTILASGGAGHIYPVTSNTMQKGGDGFAIAWKAGADLIDMEQVQFHPTGMVYPESRRGVLVTEAVRGEGGILLNSEGERFMGRYDPRGELATRDVVARAIYTEIMEGRGTENGGVYLDVSHLPDEVIEEKLETMLLQFLDVGVDIRSEPMEVAPTAHHFMGGVRIDEWGRTNLKNLFAAGEVSGGVHGANRLGGNALADTQVFGRRAGISAAKNAMSSSRRHVRSLIEEEEQRIKDMVRDGSIRPAEIRDELHEAMWSDVAIVRSRRSLESAMSRISTLMDKLGDLDVPETGGFNSNLLEALELENMLITASLVTRSALIREESRGSHYREDFPETRPEWKRSILLNRKMEPQFIGR