lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MAATGLLALRTLPGPSWVRGSGPSVLSRLRDAAVVRPGFLSTAEEETLNRELEPELRRRRYEYDHWDAAIHGFRETEKWRWSEASRAILQRVQAAAFGPGQTLLSSVHVLDLEARGYIKPHVDSIKFCGATIAGLSLLSPSVMRLVHTQDPGEWLELLLEPGSLYILRGSARYDFSHEILRDEESFFGERRIPRGRRISVICRSLPEGMGPGESGQPPPALPPKLKTAAGSYLHLPTVSFGPQNQNQECCYSLLWQHRLQFWLQSRIK
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MILSVLSSPALVSGLMVVRAKNPVHSVLFPILVFCDTAGLLILLGLDFSAMISPVVHIGAIAVSFLFVVMMFNIQIAEIHEEVLRYLPVSGIIGLIFWWEMFFILDNETIPLLPTHRNTTSLRYTVYAGKVRSWTNLETLGNLLYTYYSVWFLVSSLILLVAMIGAIVLTMHRTTKVQRQDVFRRNALDSRRTIMRRTTDQITIY
The following text describes a protein:
Function:
Member of the two-component regulatory system GtrS/GltR involved in the regulation of glucose metabolism and transport, as well as regulation of the exotoxin A gene expression. GtrS recognizes and binds 2-ketogluconate and 6-phosphogluconate via its sensor domain, which accelerates GtrS autophosphorylation and concomitant transphosphorylation and regulation of the response regulator GltR; Plays a key role during bacteria-host interactions and is required for optimal colonization and dissemination in a mouse model of infection. Contributes to modulation of the type III secretion system (T3SS) in response to host cells via the regulation of the OprB transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPRSLLGRMLLLTLLAVLVAQGLSSLFWLSHLRSSQREGLLTSSRSLAYSMAASVSYFRSLPLGYRPLVLDQLRSMGGTRFFVSLNDRPLEMRALPDTPNKQAVLEIVQDVLHQRLGKEVELQVEFVSPDELRLFNGALKLDELPRSWAHYALTLEPVNPPVLVTQIRIGESEWLYIASLMPAPYVSLEPEGLQPQQVLSIVFTSLLLLLFTGLLMHWQSRPLKRLARAARDLALGSPSAALEERGASELVEVARAFNTMHERIDRYLNERGQLFSAISHDLRTPITRLRLRVELLEDERLQEKFGRDLDELELLVKGALQCVKDTDIHENVESVDLNLLLQHIAEPYLADGRVEVVGRAAEPYPGKPLALKRCIGNLLDNALKYGERARLSLEDGPEAVVLHVDDDGPGVPEQRLEQIFEPRFRLSPRGQGYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLPRLGLE
The following text describes a protein:
Function:
Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules (By similarity). Plays a role in maintaining mitochondrial morphology.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Domain:
Consists mainly of membrane-spanning sided beta-sheets.
Sequence:
MAPPTFADLGKSAKDLFNKGYNFGFLKIDSTTRAGDNKEVEFKSAASHNIGSGKLGGNLDVKYKIPQYGITLTEKWNTENQLGTVIEVNEQFGRGLKVTLDSLYAPHAGKRSGKVKLDWALPTARVTADVGVTSAPVINAAGVFSRDGWLIGAAATFDSSSNKLAATSLAFGHSTPQYTLHSFVINSTDFGASLYHKVASNVEVGTQLGWKVGGNGADYALATKYAPSRDLTVRAKVNSSSQVAVAATHSLSPALKLTLSTQFNLAANDAHKFGLGLEFDPSN
The following text describes a protein:
Function:
Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development.
Subcellular Localization:
Nucleus.
Domain:
The C-terminal conserved inhibitory domain (CCID) negatively regulates the transcriptional activity of the protein.
Sequence:
MPADSTQDEDAVLSYGMKLTWDINDPQMPQEPTHFDHFREWPDGYVRFIYSSQEKKAQRHLSGWAMRNTNNHNGHILKKSCLGVVVCARACALKDGSHLQLRPAICDKARLKQQKKACPNCHSPLELVPCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEGRRSALKRQMASFYQPQKRRSEEPEARSTQDIRGHLNSTAALEPTELFDMTADTSFPIPGQPSPSFPNSDVHRVTCDLPTFQGDIILPFQKYPNPSIYFPGPPWGYELASSGVTGSSPYSTLYKDSSVVPDDPDWIPLNSLQYNVSSYGSYERTLDFTARYHSWKPTHGKPSLEEKVDCEQCQAVPTSPYYNLELPCRYLPVPAAGTQALQTVITTTVAYQAYQHPALKHSDSMQEVSSLASCTYASENLPMPIYPPALDPQEGVIQAASPSGRAPLKVPGDCQAPRPTLDFPQEADPSGTDGADVWDVCLSGVGSVMGYLDRTGQPFSFDNEDF
The following text describes a protein:
Function:
Protein phosphatase that negatively regulates defense respones. Inactivates MPK4 and MPK6 MAP kinases involved in stress and defense signaling.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSCSVAVCNSPVFSPSSSLFCNKSSILSSPQESLSLTLSHRKPQTSSPSSPSTTVSSPKSPFRLRFQKPPSGFAPGPLSFGSESVSASSPPGGVLKRKRPTRLDIPIGVAGFVAPISSSAAVAATPREECREVEREGDGYSVYCKRGRREAMEDRFSAITNLHGDRKQAIFGVYDGHGGVKAAEFAAKNLDKNIVEEVVGKRDESEIAEAVKHGYLATDASFLKEEDVKGGSCCVTALVNEGNLVVSNAGDCRAVMSVGGVAKALSSDHRPSRDDERKRIETTGGYVDTFHGVWRIQGSLAVSRGIGDAQLKKWVIAEPETKISRIEHDHEFLILASDGLWDKVSNQEAVDIARPLCLGTEKPLLLAACKKLVDLSASRGSSDDISVMLIPLRQFI
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MMAIAMIAAFVVNLLLGLPLFLCLLLTALVGFLFVDPALFANTLPQRFFGGMDIFSLMAIPLFVLAGNLMNHSGMTPRLMRLANALVGHFRGGLGHVNVVAGVFFAGVNGSAAADASALSTLLVPAMEKEGYSRRFAAGLTAGSSLIGPIIPPSIFMILYSSLTNTSVGELFLAGVIPGLLLAAAFMLLNAVYAYRNGLQARHAAPAWGEILAALSGALTALIAPVIIVAGIVLGLVTPTESGALIALYVALVGMLQRQLNLVGLWNSLRETVRLTASIYVIIAAASVVNWLLNYAQVASEFAQLLEPFGHSPTLMLFIISAVIFVCGMLMEEVSVLMLLTPIVAPVALAAGVDPVHLGLIFTLNITIALITPPMGACLFIVATISRLDILEMFKGIWPFILVALGVLSLLILFPSLTLWLPRLLN
The following text describes a protein:
Function:
Catalyzes the C22-alpha-hydroxylation step in brassinosteroids biosynthesis. Converts campesterol (CR) to (22S)-22-hydroxycampesterol (22-OHCR, 22-hydroxyCR), campestanol (CN) to 6-deoxycathasterone (6-deoxoCT), and 6-oxocampestanol (6-oxoCN) to cathasterone (CT). Can also use cholesterol and cholestanol as substrates.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MFETEHHTLLPLLLLPSLLSLLLFLILLKRRNRKTRFNLPPGKSGWPFLGETIGYLKPYTATTLGDFMQQHVSKYGKIYRSNLFGEPTIVSADAGLNRFILQNEGRLFECSYPRSIGGILGKWSMLVLVGDMHRDMRSISLNFLSHARLRTILLKDVERHTLFVLDSWQQNSIFSAQDEAKKFTFNLMAKHIMSMDPGEEETEQLKKEYVTFMKGVVSAPLNLPGTAYHKALQSRATILKFIERKMEERKLDIKEEDQEEEEVKTEDEAEMSKSDHVRKQRTDDDLLGWVLKHSNLSTEQILDLILSLLFAGHETSSVAIALAIFFLQACPKAVEELREEHLEIARAKKELGESELNWDDYKKMDFTQCVINETLRLGNVVRFLHRKALKDVRYKGYDIPSGWKVLPVISAVHLDNSRYDQPNLFNPWRWQQQNNGASSSGSGSFSTWGNNYMPFGGGPRLCAGSELAKLEMAVFIHHLVLKFNWELAEDDKPFAFPFVDFPNGLPIRVSRIL
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MEGPNDSLASEFVLLGLSGSWETKVFLMMIFSSIYLGIILGNLSILFLVIFDSHLHSPMYFLLANLSFIDVGVASTTVPKMITDLLKEHKIISFKGCITQICFIHIMGGVEMVLLMAMAFDRYTAICTPLHYSNIMNPKICVSFVITGWVIGVIHAMSKFAFIINLPFCGPNKVDSFYCDFPRIIKLACTDGAKLEFIVAANSGFMSMGTFFLLILSYIFILVAAFVTLSAHITVVVLFFTPFDKYLFIADFAITPALNPIIYTLRNKDIKVAIKRLSKQGH
The following text describes a protein:
Function:
May function in a SRP (signal recognition particle) and GET (guided entry of tail-anchored proteins) independent pathway for targeting a broad range of substrate proteins to the endoplasmic reticulum (By similarity). Has a role in meiosis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MANAAQKKLAAQNKHILTFMLAADLIVNVLFWILRFFVRSGLSKFSKFVYAFASISSGFLHYQLHRAAAPKYDARGSLLYVGQDLLQEGVTSYMVDYMYFSWILIFLAALTSVKVFAFYLLVPIFVVYKAAPLLKMLLQQLKNFKNQALNQPPQQQQQQQQQQHQQHATPSEPVLSKRQQKLRKKAAKYSRP
The following text describes a protein:
Function:
Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.
Sequence:
MDPAPSLGCSLKDVKWSSVAVPLDLLVSTYRLPQIARLDNGECVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGQFKLLEQDRDIKEPVQYFNSVEEVAKAFPERVYVMEDITFNVKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSISKLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQTKTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGEGWPETLIHHWLGICQEQFDIDEYSRAVRDVKTDWNEDCKSPKKGRCSGHNHVPNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIPGKSELPYEELWLEEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAMKSSDTALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPSIPPRTVKPARQQTRSPSPTLSYYSSGLHNISVTKTDTSPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWPNHYSGASESQTRSDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTKQSTSCPALPPRAPKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSKSLRFIGLSEDVISFFVTEKIDGNLLVQLTEEILSEDFKLSKLQVKKIMQFINGWRPKI
The following text describes a protein:
Function:
Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane. Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
Histidine box-1 and -2 together with other histidine residues are essential for catalytic activity.
Sequence:
MAGAEDGPGQQPELEDDEAASCRRWGAQHAGARELAALYSPGKRFQEWCCVVLCFSLIAHNMAHLLLLARWEHTPLVMLGMVAGALLADFLSGLVHWGADTWGSVELPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLLTLLPLLNMAYKFRTQSPEVLEQLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPCWVVFLQDWHVILPRKHHRIHHVSPHETYFCITTGWLNYPLERMGFWRRLEDIIQALTGEKPRADDMKWAQKIK
The following text describes a protein:
Function:
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression (By similarity).
Subcellular Localization:
Cytoplasm. Postsynaptic density.
Sequence:
MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALKKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLAKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFSELPEVLDQIQNLRELWMDNNALQVLPGVWKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTILPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEEKKEDDENAGKVKDHSCQAPWERGQRGITLQPARLSGDCCTPWARCDQQIQEMPVPQNDPQLAWGCISGLQQERSMCTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENSNPTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNTRVKVGSLQTTAKDAVHNSLWGNRIAQSFPQPLDAKPLLSQREAVPTGNLPQRPDRLPISDAFTDNWTDGSHYDNTGFVAEETTGENANNNPLLSSKARSTSSHGRRPLIRQDRIVGVPLELEQSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKEHIKESTEIPSPFSPGVPWEYHDSNPNRSLSNVFSQIHCRPDSSKGVISISKSTERLSPLMKDIKSNKFKKSQSIDEIDIGTYKVYNIPLENYATGSDHLGSHERPDKMLGPEHGMSSMSRSQSVPMLDDEMLTYGSSKGPQQQKASMTKKVYQFDQSFNPQGAVEVKAEKRIPPPFQHNSEYVQQPGKNIAKDLVSPRAYRGYPPVEQMFSFSQPSVNEDAVVNAQFASQGARAGFLRRADSLASSTEMAMFRRVSEPHELTPSDRYGRPPYRGGLDRQSSVSVTESQFLKRNGRYEDEHPSYQEVKAQAGSFPVKNLTQRRPLSARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKPSDNSDIKTRPTPVKGEESCGKMPADWRQQLLRHIEARRLDRNAAYKHNTVNLGMLPYGGISAMHAGRSMTLNLQTKSKFDLQELPLQKTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTLMGSQSLQHRSREQQPYEGNVNKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV
The following text describes a protein:
Function:
Transcription factor involved in the cell wall damage response. Required for expression of numerous cell wall biosynthesis inhibitor caspofungin-responsive genes. Plays a key role in adherence, hyphal development, and virulence (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes to the cytoplasm under basal conditions and translocates to the nucleus during caspofungin treatment.
Sequence:
MENYLMSSPSQHHHPHQQPHQQHNPYANSDTLTNLPNLENDLDFSDSEVVPPSKDYQGSPNVYDGLDFSTDMATDFVYDSTLEFDLDDHKHMPDPAEMGHSKHFSVDRPLSAPFYLSQNSRTNFNHSRNISLDDTAYKRSFHKHSASLVSNAAEPPSGTFAHSHSSNTLQSSSDSMPQLSSSVSNPSLLDSPHSAMQTATPGRRHKSSSVSSHTNLYTTPLRGGTHVSPLTHTKVGKTPIGKTHRRNRSRASLEPSSAHLLATVANMKGTSNASNLALSSAQTPSGHLTASTSQHFHGINLSEANPFHNEFVSPGVGSGHLSDHDATPLNTPAGRDHSSMASQFFTPISHNRSFGGSLLESSSSAMGSAASAFPSNLSSNDLSVASSSNSSARPGMAPLRRNDTLDSITIEDQEDDACKQLRKAKSFTSFAEQRMSQLMKQRAGKSSKDLGNVFTDSTPDASSSGRSPRKDSSSGNSYSKSASVDLLSASLVVPDHNDSYLKSYPASMDLASITNASSGNHASPSPPKTSSRLMPPIESQEPSSSRSRGSSTSKPRQTLASAAAKKLNKKVPQTYPTASQIQKAATTEDIAKFAESILQSENKRPIFVKKQEEEVYDPKKKHKCPLCLARFQRPEHVKRHLKSHSSEKPFQCEEPNCGRRFNRKDNLKAHLKKIHHKNL
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Has a role in the formation and/or maintenance of specialized chromatin at the centromere.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MRTELSSNIRIKHDKKIQKLLNRFPRDFLVKLCVEWIQKQTYPPNAKDINLEDMLDDEEWNPEAFYKNVPKSMLKRSIIHRMLVYDWPNGFYLGQIAQLEILALAHGFVSMRWTASKVHHSAEKTVLPNPLVFLELLKSELESIFVYHTYISRHETLPITFIRLVLWDSKRPTALHTYPSSKQIFYLGLMDDSDVLLHNIFLRNDVCHSLFLQCLSRLLYRLKAGSALRPIDLVSKNLTTFCTNVGVNKEANALGAWQIYAKNLVDRSPLDTRPILSDDNSSLIADSTQNCEKHREMAIQRRFGDTHSQVLDKLLITLDHDYIEKSTEKDKVLEENVESYNPTEQRPLVVMQLRGQHILEGLKDICRQDALDPFTMPSYLTGETGLSILYVRDGLVLQRQESLGQQEIN
The following text describes a protein:
Function:
Crystallins are the dominant structural components of the vertebrate eye lens.
Sequence:
MPNAKRLFYDVLLAQAVWTKGLSCSGAIKGSGCSAGTTLSQEDHRATMTSSSMNMMGRIVFYEDRNFMGRSYECSSDCADMSSYLSRCHSCRVERGCFMVYDRTNYMGNQYFMRRGEYADYMSMFGMSDCIRSCRMIPMHRGSYRMRIYERENFGGQMYELMDDCDNIMDRYRMNNCMSCHVMDGHWLMYEQPHYRGRMMYMRPGEYRNFTNMGWSGMRFMSMRRIMDSYY
The following text describes a protein:
Function:
Phosphatase that converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. Is also able to hydrolyze inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate.
Sequence:
MSLCNLAKIRSVAIKAVEKACIACLDIQKQLISEDTINKKDQSPVTVGDYTVQALVINELLKGLDEEYPIIAEEDSKTLSSQKDVESKVLSFFNRYSNESFVESQLSSLLDKGNKKKDLNSSNRWWTLDPIDGTLGFLRKDQYAVALALMEDNKPILGILGCPNLPVSKGSTEKGCIFVGLKNKGSFMIKLSNLDQEEPIKVSNQSDPTKAIFTESFVSRGFGHELNQKISNSMGVTAEPLKIDSQCKYAMVARGDSDCYLRLTQLDYKECIWDHAAGHIIVEEAGGIVTDFKKQQLDYSKGFKLENNVGIVCSNKLLNDSLFDSIKKSIQF
The following text describes a protein:
Function:
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ. Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment.
Sequence:
MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQQQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSFASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVEAAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLYELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGMEQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQTEGCQPVYV
The following text describes a protein:
Function:
May act as a carbohydrate transporter.
Subcellular Localization:
Endomembrane system.
Sequence:
MAVKMHLSFFILATIGCMPLVSVSSTTHVVGHKLGWNLPSYPGFYDDWAKKQTFVVGDVLLFQYHPGQNTVVQVDKNDYDHCTTRNILHTYFRGNSSATLEKPGDYFYFSSVGKHCDFGQKLHVTVSQ
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MDEQTNEFFNPPEADFTGGFASPPADDSQIGDVYYGDEQTGEFFNPPAAVDEPAAATGGEADGNGHAIILGEAPPVDAADASMGFAAAASNTNTLIEDVDDEDDADPAASAAWFPPNPRPWPNGTTNDENAAKASQLEAAQNEIAAFQAEREKRRESRMAKNRSDEQDKLEAIEADLENDNSWQRVVKMVELNQDGGEGSADTGRMKDVLVLLKNEPGRADALTV
The following text describes a protein:
Function:
Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.
Sequence:
HPEDIYPLLKLKVAAQYAEKQIPSQPHWAFCYIMLHKICIFYLVLRALDTVEDDTSVATEVKVPILMSFHRHVYDREWHFSCGTKDYKVLMDQFHHVSTAFLELGKQYKEAIEDITMRMGAGMAKFIYKEVESIDDYDEYCHHVAGLVGLGLSKLFHASGKEDVASDSLCNSMGLFLQKTNIIRDYLEDINEVPKCRMFWPRQIWSKYVDKLEDLKYEENSVKAVQCLNEMVTNALSHIEDCLTFLSTLRDPAIFRFCAIPQVMAIGTLAKCYNNIEVFRGVVKMRRASLSFNFVAIFSLPSYWQLLRFLGSSFLGLTTQVIDRTRNMADVYGAFFDFSCILKSKVEFKDPHVAKTLKRLEVILRTCKNSGTLNKRYVTYPSIFPKFYEYQLMHLPMITRKSFVIKSGPNYNSTFVVVLVVLVAILLGYQSGNRI
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus.
Sequence:
MGKKQSEISAMEIDDPKSESSDQILPRFSINVLQLMKSSQAQHGLRHGDYARYRRYCSARLRRLYKSLKFTHGRGKYTRRAILESTVTDVRFLHVVFYMAERAWSHAMEKRQLPDGPNARQRIYLVGRLRKAVKWASLFSSLCSIKTDSRTSLEAEAYASYMKGTLLFEQDQNWETGLACFKNARAVYEELGKYGDLENQVLCRERVEELEPSIRYCLHKIGKSNLQTSELLQIGEMEGPALDLFKAKIEAAMEEARSQQAASLTEFSWLGYRFPVSNPKSRVSILKAQELEKELQSPTAESLPAEKKLTIFDKLFTAYHDARNTIRSDLVSAGNAESVKDDLNGLDKAVGAVLGQRTIERNQLLVKVAKSKLNRKRDDKNDKVTRPEELVRLYDLLLQNVADLSDLISSGRDRKPEEIAFEEECQRTSLAFRAERCFYLAKSYSLAGKRAEAFALYSRARSLAEDALNKFQSIAKKDEGTIQELKTLIKECRANSCIEHATGIMEEERAPENLSNRMSTISLNNTAAQVEEKYLLDKLDVYESAVGDSNTKTAPKIERFPPALQSIPRNPIVLDLAYNCIDFPVIENRMKKKGGFFSSRISSLW
The following text describes a protein:
Function:
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
Subcellular Localization:
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Sequence:
MTRLTLALDVMGGDFGPSVTVPAALQALNSNSQLTLLLVGNSDAITPLLAKADFEQRSRLQIIPAQSVIASDARPSQAIRASRGSSMRVALELVKEGRAQACVSAGNTGALMGLAKLLLKPLEGIERPALVTVLPHQQKGKTVVLDLGANVDCDSTMLVQFAIMGSVLAEEVVEIPNPRVALLNIGEEEVKGLDSIRDASAVLKTIPSINYIGYLEANELLTGKTDVLVCDGFTGNVTLKTMEGVVRMFLSLLKSQGEGKKRSWWLLLLKRWLQKSLTRRFSHLNPDQYNGACLLGLRGTVIKSHGAANQRAFAVAIEQAVQAVQRQVPQRIAARLESVYPAGFELLDGGKSGTLR
The following text describes a protein:
Function:
Subunit k, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (By similarity). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (By similarity). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria (By similarity).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MAGPESDGQFQFTGIKKYFNSYTLTGRMNCVLATYGGIALLVLYFKLRPKKTPAVKAT
The following text describes a protein:
Function:
Implicated in enhancement of V-sense gene expression. Acts a an inhibitor of C-sense gene transcription (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform RepA]: Produced from the unspliced transcript.
Subcellular Localization:
Host nucleus. Host cytoplasm.
Domain:
There are 3 rolling circle replication (RCR) motifs. RCR-2 may be involved in metal coordination. RCR-3 is required for phosphodiester bond cleavage for initiation of RCR; The LXCXE motif specifically binds to host RBR1.
Sequence:
MASSSSNRQFSHRNANTFLTYPKCPENPEIACQMIWELVVRWIPKYILCAREAHKDGSLHLHALLQTEKPVRISDSRFFDINGFHPNIQSAKSVNRVRDYILKEPLAVFERGTFIPRKSPFLGKSDSEVKEKKPSKDEIMRDIISHATSKAEYLSMIQKELPFDWSTKLQYFEYSANKLFPEIQEEFTNPHPPSSPDLLCNESINDWLQPNIFQVSPEAYMLLQPTCYTLEDAISDLQWMDSVSSHQMKDQESRASTSSAQQEPENLLGPEA