lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver.
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MYTLLHGFYKYLVQKDEYCVLILGLDNAGKTTYLEAAKTKLTKNYTGIHPSKITTTVGLNIGKIEIAGIRLNFWDLGGQSELQSLWDKYYAESHAIIYIVDSSDRDRIDDSKETFDKMIANENLRGVPLLVLANKQDIPECMGVREVKPIFNKNAHLIGKRDCMVMPISALTGDGVDEGIKWLVDCIKRNSFIRPARNHEEN
The following text describes a protein:
Function:
Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MASIRRTLSPVPRAGTLLNGEACQVASPLSKSSYSQSYPSSGGLLPSIFGPSDSQAFVYGVFSPRSSRPLERSKPEGQVWKRALSHFFVCFVIGFRTWTVAKLTVNRNKDFVEGSICNGTQAIGWHVNESSRRFQRFDAGMSGFAFNSIIIWDPKRWHRPTPEPIRQLEIVKDGFQVCTFIEQVVEHESQMEGLLEDCSGVMAWHLQLQFHILGSISPPIG
The following text describes a protein:
Function:
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLDKNKIQISIGKNPSKTFYKLQLLLKDHFPENLKTKFSFQTASGIFTGENGQIFTDEVEKIIYLGLGETSKIKIRGVAQHFFQFGEKLKKWEGVGLEIHLPKVLTNSLSADLVVYQIVNSLEQGVYAINVLAKEYKENSKKIGNVSFILQDAAKLKEAEKGLKRGKIVSRYINGVRHIAHLPANHFTPEEFVSRSKEIAKDNGLKITVFDEPQLKKEKMGGILSVCEGSDKKAKMILLEYTPVKPITKKKLAIIGKGLTFDSGGISIKPAQDMHEMKYDMCGAATAIHAIGAIAELGLGVPVIAAIGVAENMPDAAAIKPGDVYTAYNGITVEVQNTDAEGRLVLGDVLSYVGKKFKPDYMLDLATLTGAIIISLGHEAAGVMSNSDVLTNLLKEASISSDERIWEMPLWEEYSEDLKSDIADIRNVAGRAGGSLSAAKFLERFVEPGIAWAHIDIAGTAWRKKTSGTQIGNGPTGYGVRLLVDLVEKIGKKK
The following text describes a protein:
Function:
Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Secreted, extracellular space, apoplast.
Sequence:
MQYVLITLTRALGDSFIFISLGTVKPRFAVQGSGPRSKRMSGSAAAVEASVLHISSSNSQLVQRVKASMEATNVDCSAERKKSLRARYFYGLIFFIINLTAWFIRDYGQSVLPRLYYRKACGVSGSDCFHTMGVLRVSLGCFIFFFLMFLTTFSTRKLFETCSKWHSGWWALKFVLLVVSIVVPFFLPPDFIHIYGEVARIGAGVFLLLQLISVIEFIGWWNNNWAPDEQRKQSCFFALFTSTVFYVASICGIVSMYYFYAPRPACSLNIFFITWTSILLIVMMAMSLHSKVNRGLLSSGIMASYVVFLCWSAIRSEPADEKCKLEKPKDGHGDWTAILGFLIAIGAIVMATFSTGIDSKSFQFRKDEVKLEDDIRYNYGFFHMIFSLGAMYFAMLFISWNLENSARKWSIDVGWTSTWVKIINEWFAATIYMWKLIAPVVKQPRPNTQACYSLAKERIGCGQVPFAKQLGFLPPAGGVAIPKANGALPPVNGINGIPLRTGQGGTAFAGKLNNQNVNPHLLGPDGLGLGFGTITVIDDILTSSTELGSQAVGKARGVYAASSADGTTQMMAFTALIEGGEYGDSLNFYGIYKIGGTMSRLSVTGGTGKFKNVRGLAEVRALIAPGQHVIDGAETLLRTLVHISYRECFRTKELIFFLSNACWHI
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Subcellular Localization:
Membrane. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Sequence:
MSINPLASKIASPYARALYDFSVEQNIMHQVTADFQNLDVFLAEVPTLMEYLGNPIVTATQKEALLTKTLKSQLNAETFKFLMVLVKRDRINLLPTIITTYLELVYKTASVKMIEVSTAFPFTTLQKLNLIKKLKELTNAREIRLVVTVDSSLIGGFLIKTNSKVIDFTIKNQLENLAKHLDGVLEI
The following text describes a protein:
Function:
Probable oxidoreductase.
Sequence:
MTFRYTPEEIEELCKIPPWTDSPLDKQNKLIYDQVPLTRKCIVDQCLFWCDVAQRFKHNLHFKRKHPTDSQNPNASDPYGEFIVGIVGCGSVGSKFVKELLKREIVRPEQIRISSRTPSRAKQRCGLEVVQNNVEVASHCTILFLFVLPFHFRNFSREIRDAIQGSRPLVVSSLAGFTPMYLQRALNTPFLITTGVDMDTIKAAAQHLDEEFPLASFATGEELVHFQEYFVGVFQEVNQQNSKLTFSDLNPQQPEQDLKNAYNPFQATISNPKTLARLHRASFAAESLANCGIDFLNSTITALKDWISLDPAYTRIQIKEETYNKLWARSFIPLSSLTRVESIYTSGAVEQQLPVRFMLKRAFIRSLLGNALGMNIQSEQKVSQGMPLQIPSEERPEQK
The following text describes a protein:
Function:
Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.
Sequence:
MMRFFIFLTVFCVLAQGCPKIISRASWGASPSKCQARLPRALKYVIIHHTAGASCTTESACKAQARSIQNFHMKTNGWCDIGYNFLIGEDGQIYEGRGWQTVGAHAKNYNSNSIGISFMGTFTNRVPNSVAQQAAKNLINCAVAKNVINTDYTLKGHRDVSSTECPGTSFYNLIKNWPHFKA
The following text describes a protein:
Function:
Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm.
Subcellular Localization:
Periplasm.
Sequence:
MKKWLCAASLGLALAASASVQAADKIAIVNVSSIFQQLPAREAVAKQLENEFKGRATELQGMERDLQTKMQKLQRDGSTMKASDRTKLENEVMKQRETFSTKAQAFEQDNRRRQAEERNKILSRIQDAVKSVATKGGYDVVIDANAVAYADSSKDITADVLKQVK
The following text describes a protein:
Function:
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
Sequence:
MARYAIGDIQGCYHSMMHLLAQVDFQPGRDSLWLVGDLINRGTGSLEVLRWVYAQRDHVRLVLGNHDLHAIAVAHHIRPPHRFDTLTELFSADDGAALLGWLRQQPLMVLEDDFAMLHAGLYPQWTLPEARALAAEVEAVLQSADYLNFLQQMYGNHPAAWDDRLTGIDRLRTITNALTRMRLLDDTGAMEFAFKGEVQDIPAGYQPWFKVAARQSAQASQTILFGHWSALGLYQGEGVVALDTGCLWGRQLTAYTLETGAFTQVPLDPRDRPVGAVGDSIRGRGHGCDGRRRWPAVGARTVIDLSCLVAIIITGHE
The following text describes a protein:
Function:
Involved in pre-rRNA processing.
Subcellular Localization:
Nucleus.
Sequence:
MESTRVFVSGLPPTLTNDQLKKHFETRFHVTDAHVLPKRRIGFVGFKSSEAAQQAVSYFNKTYMRMSKISVDIAKPIDAEPAHRKDSRTAQPDDALGNNLKRKRDGDTIKDSKTQEYLSLLQQPSKTRTWANDDQLPDPDETDSHAQEQEQPFDVDDQEELTYAQRKKAKLGQDANESSHVPVVAGYQPTTDESDGQPSPEKHEEELEDPQKDQAPVSDSDWLRSKTSRLLGLLDEDEQETFASPAAATNPTPIINSNVEKPEAESPEKPAESDLTKAPTAAEVDTNIENIRISARLFVRNLSYETKESELEPVFSPFGKIEEIHVAFDTRFTTSKGFAYVQYADPDAAVEAYRNLDGKIFQGRLLHILPASQKKTYKLDEHELSKLPLKKQKQIKRKQEAASSTFSWNSLYMNADAVMSSVAERIGVSKADLLDPTSSDAAVKQAHAETHVIQETKAYFKANGVNLDAFKQRERGNLAILVKNFSYGTKTEDLRKLFEPFGQITRLLMPPSGTIAIVAFARPDEAQKAFKSLAYRKLGDSILFLEKAPKDLFEADVPPQNPLPETKAVSQGFSTADTFAADEGDEEVMATATLFIKNLNFSTTNQSLIEAFRPLDGFVSARIKTKPDPKNPGQTLSMGFGFADFKTKAQAQAALAVMNGYTLDRHTLVVRASHKGMDAAEERRKEDTAKKIAARRTKIIIKNLPFQATKKDVRSLFGAYGQLRSVRVPKKFDRSARGFGFADFVSAREAENAMDALKNTHLLGRRLVLEFANEEAIDAEEEIQRIEKKVGEQLDRVKLQKLTGAGRKKFTVGAQDDES
The following text describes a protein:
Function:
Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA.
Subcellular Localization:
Nucleus.
Sequence:
MPDRDSSYLSGGGGSCAILVDEGPGSGLAGGSADVGGSVCGSEGMGGGAALGNGSSGVGGQGAGLALDGICRDFIRNVCKRGKRCRFRHPDVNEVPDLGVQKNEFIFCHDHQNKECLRASCRFVHGSREDEDYYKKTGALPPRLRGKVAARLGLSPMDLPHSRGEVPICRDFLKGECQRGNKCKFRHVKKDYEYEPSWAGVGAIMGQGTSGVVNTGGGMGGGGVTCGAMQGLVGGGSVGNIMGTGCPSLGVCRDTAISGVGGVGGSGMSGCLSLGSSGQRRYDRSSVYEPLLDSGLLEASSLEASMDHTSLQLKRRRLEGLRLTDGSGSGHYEFGVQATLPSRPLEYRFLEEENALLRKRVEELKKQVTNLLATNEVLLEQNAQFRSQAKVMTLSSTPAPTEQNLAPPVGAVSSYNHSIAQTHTTLSSAGLQPRPVTQQDLVAPTGAPSAPPTNAAPPTAPHLNPEITPLSAALAQTIAQGMAPPVSMAQVAVSVAPVAVSMTQPLPGITMSHATTPMVSYPIASQSMRITTLPH
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTSNDVRDILSLPERPASQPSSSAQASGSSSRNRKSSGSNNPHPSSAASASRPKPKYDGMTRELFALLGDNAPSLAMTHGLDAEGKPVMGLGGLFKPKFKRRKEKVRQWRWTPFLNSARDDTQIDDDVPEINHGLILHHWAPARSFSTTAADGISAEDADIDTKYQYAAFNTTSGVYSYSNDEYIQHLRDDDWTKEETDYLMELCTAYDLRFVVIHDRYDWAAAQASFLAGSTSAVPQPVKERSMEDLKVRYYAICRRLIRSRISTDDVETRQMLLSTYAFDKQREVERKKAVARLYTRTPEQLAEEEALYVEIRRIEQNEAKYASEREELLRLLGGWESLPSSSPHAVAAAGSGIASLLGAEEDSTAKGRAGSANKKRKLQQIEDNGTPGADDAGSSTGATAAATSRPSANLTSKQRAELRQAQFDEMQCIVRFASNANATTDASAGGIAGPAAVSAASSSTRPPYAYLVGTASTLPAVTSNPANPTSGHGVYLRSSRMLAPRPNLVLRTTQVLSESDPPVGPRLIFPTAKNVEKWENLIGAVTTGLEMRKQLERVNAELRIAKQRIAAALHPNRMADKSEASAEAVESRSAAPTENSIAATTSTHAQITIKTE
The following text describes a protein:
Function:
Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription.
Subcellular Localization:
Nucleus.
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGDEEKENNRASKPHSTPATLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSK
The following text describes a protein:
Function:
Transcription factor that negatively regulates jasmonate (JA) signaling. Negatively regulates JA-dependent response to wounding, JA-induced expression of defense genes, JA-dependent responses against herbivorous insects, and JA-dependent resistance against Botrytis cinerea infection. Plays a positive role in resistance against the bacterial pathogen Pseudomonas syringae pv tomato DC3000.
Subcellular Localization:
Nucleus.
Sequence:
MAEKFFLKGEDKVNMEGVLGSEAVEFFSWSASNHMLTEFTSSRGDLGVQQALCKIVEGSDWTYAIYWQVAKSKSGKSALIWGDGHCRETKIGQGEGANDSAHQKMMDGNKKKMVLQKIHTCFGGSEDDNIAAKLESVSDVEVFYLTSMYYIFPFDKPSSPSQSFNSARSIWGSDLKGCLEHFQSRSYLAKLARFETLVFVPLKSGVVELGSVKSIPEDQNLIQMVKTSVVVSNPPQPKANTKIFGRELSLGGAKSGPISINFSPKVEEELSFASDSYEVQAALGSSQVYGNSSNGYRSDEGEGKLYKEELDERKPRKRGRKPANGREEALNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAIAYITDLQARIRVLDAEKEMVGDKQKQQVILEIDFHQRQDDAVVRVGCPLNAHPVSRVLKTFQEHQVVAQESNVSLTENGELVHMFSIRAPGPAAEDLKEKLTAASRFALKTRWSVSVIRLLCFARLFVYEHQCLAGKFALYFVDYTI
The following text describes a protein:
Function:
Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MNLEAPRSHCKTQSREIFWMKKLSEQKFQERKEERNPQKTKEAKLLLYLLRKIMDRHQVLYLHSVSTVILLLIWTGASEAQKDCTGVECKQLENCIEEVLEPDECCASCLQHGCTCEGYQYYDCVNVGFVNGKVPEGQSYFVDFGSTECSCPKGGGKISCQFMLCPDLPPNCIDAVLPADGCPQCGRIGCVHEDQKYAAGHTFHMPPCKVCHCPNAGGDLMCYELPDCNESHKPSDPGDAEAEKHYDDPYTYDQEALEGDITQVEPPKKYYSYSAQTEQESLGQEQSEDYDYLANSVTPSLTSYSISYPTAVSLTSTNVPTMRHLETSHTTEKREERHMSTVTTPNGQQSHHKITTTKNILKGKKTAFTTEMPRNMAGERKNLAHRERNEQEENARFRIKLNMKKDNKQKENKLLAIKEANTTQSHGLNTLQEKGDDFPQVKFNPTPPSLIALKEENNRISQKQPQTLYHYQPDEDVDPNSVYTPSRLPEGSTKDLIETCCAAGQQWAIDNSECAEIPVSGTDGDICRIAQKQCCASYLKENSCIAGMIAAREGDVCEPDESDTCGGSFYKQCCDCCTVGLRVKNEGQSCESNPNLGYPCNHMMLSCCEGEDHLNPPELKRHPEPLSTVTPEKLSETEDHNEALSISNEAELSNNLPGDDLDECLAYPGELCQHLCINTVGSYKCSCFPRFTLQDDGLSCNPDFEEEGPNTALGDKATVEPEPLKNPSVTVNGLHEEQDRCKDNGPCKHTCNIVEGRIECSCLPGYALMADGVSCEDINECITDAHTCKRGEHCVNTVGSFTCLQQLSCQSGYELKEGECVDIDECERKTHSCKINFVCQNTKGSFYCESKQRCMDGFLQDPEGNCVDINECTSIPEPCKAGFNCINTVGSYTCQKNLLVCSRGYHSSEDGTRCVDVDECQTGVHRCGEGQICHNLPGAYRCDCKMGYQYDSFSRTCIDINECWNYPGRLCQHSCENTPGSYHCSCSLGFRLGYDGKHCEDVNECDNNPCSQECANIYGSYQCYCRQGYQLAEDGHACKDIDECAQSAGILCTFRCLNMPGSYQCACPDQGYTMSANGRTCRDIDECAMGTHNCSSSESCYNIQGSFRCLLFECPSNYRKVSDMRCERINCFSYLDCQSTPLRITYYQLNFQTNIVVPAHIFRIGPSPAYAGDNIVLTINKGNEDNYFSTRKLNSYTGIVYLQRQVKEPKDFLLDVEMKLWRQGTYTTFLAKIYIFITSHSY
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
Sequence:
MAEYWLVSAPGEKTQQQTYEALKSRMVGMSPVYKFPIPELKVGTLDTLVGLSDDLNKVDSFVESTTRKLAHYMVDVLEEHQDRVKENLLANGHELSNYVTKFQWDSAKYPIKQSLRNLTEIISKQVSQIEHDLKTKSAAYNNIKGTLASLERKSTGSLLTRNLGELVKKEHFVLDSEYLTTLLVVVPKALFNEWKEKYWKLTDMVVPESSKLLFEDNEHGLFTVTLFKKVLEEFKHHARDNKFLVRDFVYDEQALSAGKNEISKLESDRKRQFGPLVRWLRVNFSDSFTAWIHIKASQKVFVESVLRYGLPVNFQAMLLEPSKKTQKKIRDSLDTAYSYLESKSFSATVNEQAIDIPGLMISHQQYYPYVFYNIKLNLLER
The following text describes a protein:
Function:
Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus.
Subcellular Localization:
Mitochondrion.
Sequence:
MATSAVLSGARSMLRAASSRSAAASTGRFASQAKSAPPLFRATARRSPLLSPLRNPVELSFCVESLLPYHSATASALMTSKLSISGQTYGWLSDACNDDV
The following text describes a protein:
Function:
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Sequence:
MAKLVTNTNARPATKRVISESSSEEDTPIAKRSKSDTKSAQQATLPTPNSEPSQDPPTSSALSSEDEIEGEEATPKEEEEAGDDEDEEEDEEVDDSSDDDQPIANSNYKPTLTPKRSIDESSASTTLTTNTDRPITDVRKLPAIKKNSQPIKPKPDPDSSSDDDQPLVSRQPAPATVPVTTAKQRVSVKKEESESDDSKPLVSRAAAKPKTTKTTRASKRAAPKTPAKGKQPKRKKNANNDDDDEDEDGDAKNGPDGENRPDGETQQDAEAQQEEAMYRWWEENKDDDTKKWSTLQHNGVLFPPEYEPLPGHVKMKYNGKSVDLPPESEEVAFFYGSMLNSDHVKKAVFRQNFFHDWLEVLKEHPPRDGTKIKEFSKCDFTPMFDYASDEREKKKAMSKEEKMKMKKERDALEAKYKTCILDGRVEKVGNFRVEPPGLFRGRGEHPKTGKLKKRVRAEDIHINCGADSKFPEPPPGHKWADITHSEKASWLAYWKENINGNFKYVFLAAGSSLGGQSDLKKFEKARKLKDIIDDIRNDYQTKLRDRMMAVRQRATAMYLIDRFALRAGNEKQAGEEADTVGCCSLRAENITLEPPCTVTLDFLGKDSIRFFNKFEVDEAVFKNLKIFTKGSSPRDEIFDRLTTGTLNKHLSSYMSGLTAKVFRTYNASITFERQLAKNMLELGEDAKEAEKMVAYNKANRQVAVLCNHQKAVSKSHGASMEKCADRIRILKYRRRLCRIALLNHADGLDRSSRAKYQQDESDLDEEWMDRHEAVTEEKKRELIEKRYKKWDEELEKPAEQREQVKKAKEEDAQKKVKTEVKRKVKSVKAEEEAEVKAEEDGPRGTKVSPFERYAAMDRAQREEARRQELLGCEGIAESMKAKRLEGYPRETAVAELVKRIGNFDKEILIAKSLQKDRDEGKETSLGTSKTNYIDPRLSFAWAKKYDVKPAKIFAKTLQEKFTWAAATPADWKF
The following text describes a protein:
Function:
Controls proneural and vein forming genes. Positive transcriptional controller of ac-sc (achaete-scute). May act as an activator that interacts with the transcriptional complex assembled on the ac and sc promoters and participates in transcription initiation.
Miscellaneous:
MISCELLANEOUS: 'Caupolican' is named after the Araucanian American-Indian tribe, also called mohawks, who shaved all but a medial stripe of hairs on the head.
Subcellular Localization:
Nucleus.
Sequence:
MAAYAQFGYAGYPTANQLTTANTDSQSGHGGGSPLSGTNEASLSPSGGSTATGLTAGPLSPGAVSQSSHHAGHKGLSTSPAEDVVGGDVPVGLSSAAQDLPSRGSCCENGRPIITDPVSGQTVCSCQYDPARLAIGGYSRMALPSGGVGVGVYGGPYPSNEQNPYPSIGVDNSAFYAPLSNPYGIKDTSPSTEMSAWTSASLQSTTGYYSYDPTLAAYGYGPNYDLAARRKNATRESTATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNKTEDDDDGMMSDDEKEKDAGDGGKLSTEAFDPGNQLIKSELGKAEKEVDSSGDQKLDLDREPHNLVAMRGLAPYATPPGAHPMHAAYSSYAQSHNTHTHPHPQQMQHHQQQQQQQQNQQQLQHHQMDQPYYHPGGYGQEESGEFAAQKNPLSRDCGIPVPASKPKIWSVADTAACKTPPPTAAYLGQNFYPPSSADQQLPHQPLQQHQQQQLQQLQQQQQHHHHPHHHHPHHSMELGSPLSMMSSYAGGSPYSRIPTAYTEAMGMHLPSSSSSSSSTGKLPPTHIHPAPQRVGFPEIQPDTPPQTPPTMKLNSSGGSSSSSGSSHSSSMHSVTPVTVASMVNILYSNTDSGYGHGHSHGHGHGHGHGLGHGHGLGHGHGHMGVTSNAYLTEGGRSGS
The following text describes a protein:
Function:
Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance; Multifunctional protein that functions as a downstream effector of RALA and RALB. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity. As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis. During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of RALA. Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
MTECFLPPTSSPSEHRRVEHGSGLTRTPSSEEISPTKFPGLYRTGEPSPPHDILHEPPDIVSDDEKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESPSKMKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEEKHKEEKHKEKKSKDLTAADVVKQWKEKKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYDREESTNLEEYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVFFTHVQELFGNVVLKQVTKPLRWSNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQECETKIAQEIASLSKEDVSKEEMNENEEVINILLAQENEILTEQEELLAMEQFLRRQIASEKEEIERLRAEIAEIQSRQQHGRSETEEYSSESESESEDEEELQIILEDLQRQNEELEIKNNHLNQAIHEEREAIIELRVQLRLLQMQRAKAEQQAQEDQEPEWRGGAVQPPRDGVLELKAAKEQPKAGKEPAKPSPSRDRKETSI
The following text describes a protein:
Function:
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Sequence:
MAPKHLNRRRHLLFGAAAVLVLLPSGSSATAVEYCKKGRDYPVKVSGVEVVPDPVVRGEPATFKISASTDKNITKGKLVIDVAYFIFHVHSETHNLCDETSCPVTGEFVLASQQTLPSFTPPGSYTLTMKLQGDSNEELTCISFGFSIGMCAQLLSCIRSWTPDLTI
The following text describes a protein:
Function:
Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MVPKADSGAFLLLFLLVLTVTEPLRPELRCNPGQFACRSGTIQCIPLPWQCDGWATCEDESDEANCPEVTGEVRPHHGKEAVDPRQGRARGGDPSHFHAVNVAQPVRFSSFLGKCPTGWHHYEGTASCYRVYLSGENYWDAAQTCQRLNGSLATFSTDQELRFVLAQEWDQPERSFGWKDQRKLWVGYQYVITGRNRSLEGRWEVAFKGSSEVFLPPDPIFASAMSENDNVFCAQLQCFHFPTLRHHDLHSWHAESCYEKSSFLCKRSQTCVDIKDNVVDEGFYFTPKGDDPCLSCTCHGGEPEMCVAALCERPQGCQQYRKDPKECCKFMCLDPDGNSLFDSMASGMRLVVSCISSFLILSLLLFMVHRLRQRRRERIESLIGANLHHFNLGRRIPGFDYGPDGFGTGLTPLHLSDDGEGGTFHFHDPPPPYTAYKYPDIGQPDDPPPPYEASIHPDSVFYDPADDDAFEPVEVSLPAPGDGGSEGALLRRLEQPLPTAGASLADLEDSADSSSALLVPPDPAQSGSTPAAEALPGGGRHSRSSLNTVV
The following text describes a protein:
Function:
Reductase involved in lignan biosynthesis. Catalyzes the enantioselective conversion of (-)-pinoresinol into (-)-lariciresinol and of (-)-lariciresinol into (+)-secoisolariciresinol. Abstracts the 4R-hydride from the NADPH cofactor during catalysis.
Sequence:
MGRCRVLVVGGTGYIGKRIVKASIEHGHDTYVLKRPETGLDIEKFQLLLSFKKQGAHLVEASFSDHESLVRAVKLVDVVICTVSGAHSRSLLLQLKLVEAIKEAGNVKRFIPSEFGMDPARMGDALEPGRETFDLKMVVRKAIEDANIPHTYISANCFGGYFVGNLSQLGPLTPPSDKVTIYGDGNVKVVYMDEDDVATYTIMTIEDDRTLNKTMYLRPPENVITHRQLVETWEKLSGNQLQKTELSSQDFLALMEGKDVAEQVVIGHLYHIYYEGCLTNFDIDAAQDQVEASSLYPEVEYIRMKDYLMIYL
The following text describes a protein:
Function:
Blocks the binding of HNRNPA1 to the intronic sequences flanking exon 9 of the PKM gene by competitively binding to the HNRNPA1 RGG-box motif. This inhibits inclusion of exon 9 and promotes inclusion of exon 10, suppressing formation of the PKM M2 isoform and promoting production of the M1 isoform. Also suppresses HNRNPA1-mediated processing of microRNA 18a (miR-18a). Promotes MYC stability through interaction with IGF2BP2.
Miscellaneous:
MISCELLANEOUS: By blocking HNRNPA1-dependent PKM splicing, inhibits colon cancer cell aerobic glycolysis and suppresses colon cancer cell growth, colony formation, migration and invasion. Promotes the proliferation and viability of oral squamous cell carcinoma cells.
Sequence:
MPVLPGTQRYPHQRRRFQAAGGGAESGKRGSEEAPGVAWSGSESGRDAATPAW
The following text describes a protein:
Function:
Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
Subcellular Localization:
Mitochondrion.
Sequence:
MTCYRGFLLGSCCRVAGGRAAALRGPGAGGPAARPRLGGDGGGRRHLGQGQPRELARCGSRADGGFRPSRVVVVAKTTRYEFEQQRYRYAELSEEDLKQLLALKGSSYSGLLERHHIHTKNVEHIIDSLRNEGIEVRLVKRREYDEETVRWADAVIAAGGDGTMLLAASKVLDRLKPVIGVNTDPERSEGHLCLPVRYTHSFPEALQKFYRGEFRWLWRQRIRLYLEGTGINPVPVDLHEQQLSLNQHNRALNIERAHDERSEASGPQLLPVRALNEVFIGESLSSRASYYEISVDDGPWEKQKSSGLNLCTGTGSKAWSFNINRVATQAVEDVLNIAKRQGNLSLPLNKELVEKVTNEYNESLLYSPEEPKILFSIREPIANRVFSSSRQRCFSSKVCVRSRCWDACMVVDGGTSFEFNDGAIASMMINKEDELRTVLLEQ
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MNSVQIPVDISGYDEKSSGKITGQTTIAEYSVSLNREVHNDRRNAQYLHEASLKPPVNFDLTKHFGTEGMFFDKGEVKLEEKSLGTLCSWAMGQPGVTVKEVFGHADFASWRGTFKRICSTLLYKPPKDVWKSINNSGWSMVAQNIGDVIFISEVKEYDSTSNCLATYTGYKFEQYVTSNMPDCSPNTDEPVDNRPTFEDTVELKTVWEKDWNDRSVNMVLQSEIIGTKQFVLGTKRGDIRRGVCSVIKIEEKTMDEIKSTGDTQKKTSQCYGFLFDVLSEVKTFLGSKEACEIAFHPSQGIVSIRSISQADAQSNGHTLSNCPMSSIRQIVQRAALAAKDPATQMQVHWTIPDHVNPDGTPAFCLTVTRGWQYNVFKTGTEDIPDRVTIEDFISKMRHSDVRQTSKTSPTKLTVTEFDARLAQAIDRERKRRKTATKRKEMLSIINGGKDSIEKT
The following text describes a protein:
Function:
SNARE required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MSKDLISRLERQFKLKRDEFQDPLELLKFEKNLDYARKLLWEEGKCQLDKVAEPQGLSKRIMDLQGRIYDLNVTMEKKLKIEEKKIKSKQEKEIAHALQSIQERELRERQQMSNVEASNAQLLTNQRSMQTEISESLLHLASVLKENALSFTNALVTDNQVVERTGSLLDKNAHSLRHANHGVQSYSKSKRLSFWLQLGMIIAVVVSFIVMIFILQFTKNQN
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MASDDVKAALSAAGAAKARNFERTMKIMKKAVLEVQLILLDGVNTDEQLQAAGKILSQSEYSDVVEERFIAKVCGYTRCANSLDTENMRKGRYRISLSAKKVYDLEESRHFCSPSCLITSKDFGNKLPFRQDLLESAKMLEEILSSVRGSQYTARSKPTRLKEDNVIKPSARPRNVKRGKLRSKETRKAAPASSDLIDSTVEGRGHSEIIISSSKPSGVPADKILTSDNPIDFPSVSSGFNAKDTLIVSELNQNNNLASELNPSYHSVLIVPSTSNFNGKDAKEIVERSTNTPKKHLEKDSLQSSDISSKVETKFGKLSIQERVGDQPNLPIFDYGGASDAIEGYVPLRSRNKVVSSAESKTKTEVSKDGNSSGATSRREQEEQRKRISVERNTSGKEPRTTLRDKVLSSERSSSGHQNEAKVFKEWEGLLSGSSEIGPAKMCITEMDGGTAKSAAESSAAASAASTSGNTRNNGIQGKPSNLKPALKKQAKVKKGIRNVVWADQDKTAFDTGITDSKGRSSSTKVDKALITEDGFEDVKGLEDKIKSMQLEEKELPQTKLVESNLDTVMAARLASAEAIANALTEAATSAATGEVDGSDAVAQAGLSILSATHNAIPARAGSPHEAQDRSGEIPDSMKNCAVDEDELYERAVQAREEIRRLKMPRKHEVESVEEHENDDLIDDLDLEVDANFDDDGDADDDDDDDDDDTSGGFEGASEVGFMAPPKGFKAEVSLFGTIFMALESWTSGAALAHIYGKEPQEEDQYLSVNGREYSRQVVIGDGVSSEILRTFSLCVSRALPEVVRALRLPVPMSTLEVAMGKLIKNMSFVEALPPLSTKQWRMLVIVLLDALSVQRLPRLGVHLMNNRSVLRKVLDSTGTSESEYDVFRDVLLPLGRSPTFSTLSGG