lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation. Colocalizes with NR0B2 in the nucleus (By similarity).
Sequence:
MTKSYSESGLMGEPQPQGPPSWTDECLSSQDEDHEADKKEDELEAMNAEEDSLRNGGDEEDEDEDLEEEDEEEEEDDQKPKRRGPKKKKMTKARLERFKLRRMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNPDMPPHLPTASASFPVHPYSYQSPGLPSPPYGTMDSSHVFQVKPPPHAYSATLEPFFESPLTDCTSPSFDGPLSPPLSINGNFSFKHEPSAEFEKNYAFTMHYPAATLAGPQSHGSIFSGATAPRCEIPIDNIMSFDSHSHHERVMSAQLNAIFHD
The following text describes a protein:
Function:
Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Sequence:
MSEELQEDDRIFLEQAFTLAEEALNQDEVPVGCVFVVDGEEIGRGRNRVNETGDPTRHAEMVAVTEIWSKYGEESNNLLKKSVLYVSLEPCIMCSSAMYQLGIRKMVYGAENPRFGGVRSVGSAEKYREENNIEIVAGVWAERSVGMLKAFYEKQNPFAPPEKRKTKTPKLWSTTRPFCSVITWTTKSPLSTLAVLQRKTSAVNVLSIRQLNKKPSRSDKSADQKNYTYYVMSLVIVAIGCTFAAIPAYRIFCEQTSFGGLTQVAKDFDKIANMKKCEDRLIRVQFNSDVPSSMRWEFKPQQHEIFVHPGETALAFYTARNPTDKPIIGISSYNLTPFQAAYYFNKIQCFCFEEQILNPGEQVDLPVFFYIDPDYVNDPALEYLDSILLSYTFFEAKSGLKLPDPFDPKNRPSIAPSPDKVPEKSN
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation in the hippocampus dentate gyrus. Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation. Promotes formation of synapses via its interaction with FZD5.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
LGHSSSWCLWENTFAALSLDFFRCNLSPKAPSSLDWAVYHGKGSGPLASSDAVPAREPGLPAPPARCRRERALSRRLRPEPSGGSAAPRLGCERGVQASARLRLSSRSGIPAEAVSPGHPPAAPPRIDGGEEEYAEPSHPPPPLALLKGAPSPKAGETGGELSTTPPPPQLRALRGTGRQARARARVLGLAPIPPEPEGCPCASVRPAVGELEPEWRLREDSHCPPPGWAPRSREGAPRERVGQARARSEQEALSRGRGGAGRALRGGGRGGGGGRWEGRGRAAAAPPHAPRLAHSPRPLARSPASPRAALAPPSSPGLGGSRAPGEAQAPSARTGARQTASGSLGPRLQGGLCGLPRQGRPAGSARPGPRPRRPAGTMNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPAFLKIKKPLSYRKPMDTELVYIEKSPSYCEEDPATGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEVYTCK
The following text describes a protein:
Function:
Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments.
Subcellular Localization:
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MGDDSEWLKLPVDQKCEHKLWKARLSGYEEALKIFQKIKDEKSPEWSKYLGLIKKFVTDSNAVVQLKGLEAALVYVENAHVAGKTTGEVVSGVVSKVFNQPKAKAKELGIEICLMYVEIEKGESVQEELLKGLDNKNPKIIVACIETLRKALSEFGSKIILLKPIIKVLPKLFESRDKAVRDEAKLFAIEIYRWNRDAVKHTLQNINSVQLKELEEEWVKLPTGAPKPSRFLRSQQELEAKLEQQQSAGGDAEGGGDDGDEVPQIDAYELLEAVEILSKLPKDFYDKIVVGKDTNVMLVALAAKCLTGLAVGLRKKFGQYAGHVVPTILEKFKEKKPQVVQALQEAIDAIFLTTTLQNISEDVLAVMDNKNPTIKQQTSLFIARSFRHCTSSTLPKSLLKPFCAALLKHINDSAPEVRDAAFEALGTALKVVGEKTVNPFLADVDKLKLDKIKECSEKVELVHGKKSGLAAEKKESKPLPGRAAASGAAGDKDTKDVSGPKPGPLKKAPATKAGGPPKKGKTTAPGGSASSGTKNKKGLETKEIAEPELSIEVCEEKASAVLPPTCIQLLDSSNWKERLACMEEFQKAVELMERSEMPCQALVKMLAKKPGWKETNFQVMQMKLHIVALIAQKGNFSKTSAQIVLDGLVDKIGDVKCGNNAKEALTAIAEACMLPWTAEQVMSMAFSQKNPKNQSETLNWLSNAIKEFGFSELNVKAFISNVKTALAATNPAVRTSAITLLGVMYLYVGPSLRMIFEDEKPALLSQIDAEFQKMQGQSPPAPTRGISKHSTSGTDEGDDGDEPGDGSNDVVDLLPRVEISDKITSELVSKIGDKNWKIRKEGLDEVAGIINEAKFIQPNIGELPTALKGRLNDSNKILVQQTLNILQQLAVAMGPNVKQHVKNLGIPILTVLGDSKNNVRAAALATVNAWAEQTGMKEWLEGEDLSEELKKENPFLRQELLGWLAEKLPMLRSTPTDLILCVPHLYSCLEDRNGDVRKKAQDALPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKANMPSKPAAPSKAVSKPMGGSAPAKTQPIPAPVEDSVSNTMEAKPDPKKAKAPGVSSKAKSAQGKKVPSKTTLKEDDDKSGPIFIVVPNGKEQRMRDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHADFQHHNKALAVMVDHLESEKDGVISCLDLILKWLTLRFFDTNTSVLMKALEYLKLLFTLLSDEEYHLTENEASSFIPYLILKVGEPKDVIRKDVRAILNRMCLVYPASKMFPFIMEGTKSKNSKQRAECLEELGCLIESYGMNVCQPTPGKALKEIAIHIGDRDNAVRNAALNTIVTVYNVHGDQVFKLIGNLSEKDMSMLEERIKRSAKRPSAVPVKQAEEKPQRTQNINSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQLDLDEIENDNGTVRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDISTSIQALTQIDEVLRQEDKAEAMSGHIDQFLIATFMQLRLIYSTHMADEKLDKDEIIKLYSCIIGNMISIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVIRSVNLLVVKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFMKVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKYSDTDIEPFLKNSSQFFQSYVERGLRVIEMERESKGRIPTSAGISPQMEVTCVPTPTSTVSSLGNTNGEEVGPSVYLERLKILRQRCGLDNTKQDDRPPLTSLLSKPAIPPVASSTDMLHSKLSQLRESREQHQHSDLDSNQTHSAGTMTSSSSTANIDDLKKRLERIKSSRK
The following text describes a protein:
Function:
Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC. Can use a wide range of substrates, including electrophilic quinones, and its function could be to reduce the redox toxicity of electrophilic quinones in parallel with acting as triggers for the KefC efflux system.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MILIIYAHPYPHHSHANKRMLEQARTLEGVEIRSLYQLYPDFNIDIAAEQEALSRADLIVWQHPMQWYSIPPLLKLWIDKVFSHGWAYGHGGTALHGKHLLWAVTTGGGESHFEIGAHPGFDVLSQPLQATAIYCGLNWLPPFAMHCTFICDDETLEGQARHYKQRLLEWQEAHHG
The following text describes a protein:
Function:
Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Subcellular Localization:
Apical cell membrane. Basolateral cell membrane. Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane raft. Membrane, caveola. Membrane, coated pit. Postsynaptic density. Presynaptic cell membrane.
Sequence:
MVTFNDTTDIHKMQPPSCIPNPMSPGLRRKQLLWQNAVKHIISQRGLREQFGVEPARKIHVTDAYIEEINKQIRSKASRGMTKRRSSVARVHPSFFGERSSSSSTQTGTSVDYISDADFFVHWGNIIHGVHVPTLRHIFKSKDLEKLYQRHSSHTRRTSLVVTNIIDAAAKLHLFLLYLALAPDRSDILMSWFTGFFMACAIALCVLVLTCKRSHSPKWLHYAGMASWLSQTAQVLGGLAYGLERDQSWYVLFTLFATYTLLPLPLLWAIGAGTLTSILHLTAETIRHISEVGLFRKLLAKALLYTSMNVAGLFIHYLTDRSQRQAFLETRRCIEGRMKLETENQRQERLVLSILPRFVALEMISDMTSMDDELDPQQFHKVYIHQYKDVSILFADIKGFTLLSMNMSAQELVRLLNELFGRFDRLAEEYDCLRIKILGDCYYCVSGVPEPQRAHARCCVEMGLAMISTMRSLRKQQNFDMDMRIGIHTGSVLCGVLGLQKWQFDVWSWDVGIANMLEAGGIPGRIHISRATLDCLDGSFQTEDGRGYERNEFLRKHNIDTFLICHKEDDLNEMEAEHPKTRHNNRPWNKEILASFSNGSYTQLPTSSACRSMSKEINKRIEHAIDLRSSERMRQEHITPVTLVFKDAHIEEKFSQVRDEMFKTNLVCSFIMLLLLMAVQALIPVPRMYLWTVLQFCLFLLGYLLLLVMVLAEEFKHSPGVLQQFCCWIHENNSMRNLLTITAIAMNFGMALFDMMWCNSSEMKEISTRETEGYKAGQKPLTACTYPEVFVLSGVVSMVTCAVFLRMSSLLKLTILLFVVAVYTYFIEVSFHMLYVHQQEHEHLSRSHFLRRKGVSILLMAMFMIAVLYNGRRWEATTRLDFLWRLQAQQEVQEMRDLREHNECLLHNILPAHVARHFLERNRNDQELYSQSYDEVGVMFASIAGFNDYYEQKEIKHEGVECLKLLNEIIADFDELLEESYFLDIEKIKTIGSCYMAASGLSPDKQSRVVNDWHHLSELVLFALAMQETLREINKHSMNNFQLRVGIAHGPVVAGVIGATKPQYDIWGMTVNLASRMDSTGVSGRIQVPEATRNILADWGFVLELRGEIYIKGVSERKGRVRTYFISTKRRLVSSNGIADRGKNGHTGRTTLAAVVFGLVQAIHREKQRGTNGGFTLTNSNFSNLKL
The following text describes a protein:
Function:
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
Sequence:
MASQQAAPTILAYRDSTGISVLSGSPSYAPIATPANLGASPRSFLYSPLGKYLVLVFADRLVLSKVTIEAVTVVHELPITNALEIEFSPKETYISTFIRYNPSANSATPAHRNVSVWNVETGKEVFAYTQKNASDWNVKWTEDESYCGILVGNEVQFYESKSFSNGIASRLKLDCIKLFSMSPGRRPTVAIFYPEKNGSPGSVKLYDITNLQTPLSSKSFFRADSVNFYWNSLGTNVLVFTHTDVDVTGKSYYGETSLYYLSITGNFDCKVTLDKPGPVHDVCWAPNAKEFVVVYGTMPAKATLFDHRANPMYEFGNAARNQVKFNSHGRFLFIGGFGNLAGDMDIWDRRSFKKMCTIKASNSSSCDWAPDGKHIMTSTLYKRLKVDNGIKIWHYTGALVHQVQVKEMHQTSWMPASRDLWPDRASLSPPPPSIASCAPAVSEGKYRPPGARNTASSTNFYDRDAIDRGVVSTRGKRVPGAYIPGATPEHERKNKTVQNGTTDSPAPITSGVIPGSNVEAEKRIKLISKKLKQIEDLKQKKDTGVTLELTQIQKIESEESLRAEMEKLTLSIA
The following text describes a protein:
Function:
Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MEDERSLSDICGGRLALHRRYYSPSCLEFCLSCPRISLRSITAVTCTVWLAAYGLFTLCENSMILSAAIFITLLGLLGYLHFVKIDHETLLIIDSLGIQMTSSYASGKESTTFIEMGKVKDVIINEAIYMQKVIYYLCILLKDPVEPHGISQVVPIFQSAKPRLDCLIEVYRSCQEILAHQKAASTSP
The following text describes a protein:
Function:
Phospholipase that releases free fatty acids from phospholipids. Catalyzes the initial step of jasmonate (JA) biosynthesis. Required for the biosynthesis of endogenous JA in seedling, inflorescence and spikelets. Not essential for JA biosynthesis after wounding. Mediates spikelet development and specification of empty-glume identity. Functions in a high temperature-dependent manner to maintain floral developmental robustness under heat stress conditions. Functions by safeguarding the expression of several floral identity genes, such as MADS1, MADS6 and G1.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAIHLTNPPPGLYATKTPSQQQQQHRPAGSHAAAAAAATVAMPQTASAASSSVAVKKNMRQAAPVVVARRRTTAVESGGVALASVWREVQGERDWEGMVEGTAEEELHPLLRGEIVRYGELVAATYKAFDLDAASKRYLNCKYGKARMLDEVGMAGAGYEVTRYIYAAPDLAAGPPCPSRWIGYVAVATDEAVRRLGRRDIVVSFRGTVTGSEWVANMMSSLAPARFDPADPRPDVKVESGFLSVYTSDDATCRFTCGSCRNQLLSEVTRLIAKHKHEDVSVTLAGHSMGSSLALLLGYDLAELGLNRDARGRAVPITVFSFAGPRVGNTAFKDRCDELGVKVLRVVNVNDPITKLPGIFLNENSRVLGGKLELPWSSSCYTHVGVELALDFFKARDPACVHDLEAYLGLLKCPKVTKVMKEGEDLFSKAKKIVLEQSFDTWRWQMAAIQVGGLVQALGM
The following text describes a protein:
Function:
Probable polyketide synthase.
Miscellaneous:
MISCELLANEOUS: Encoded by one of the numerous copies of polyketide synthase genes and clustered as a pair pks22/pks23 in chromosome 4.
Domain:
Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).
Sequence:
MIEGNIEKNNDNQVAIVGLGLRLPGNSGSPSEFWKNLLGGFDGIVDSNERWSDTFHSMGEISNKNAGLIDLEENWHSFEPLFFGINPTDAKQIDPQIKLMLKLTWEAFEDASIDPLKLRGTNTSVFVGAANTDYSFINFEQNEAPINVFNGTLSAFANRISYCFDLRGTSLTLDTACSSSLNAVHLGYESIVNGKSNYSVVAGCNILLNPYITRSFHSINITGKSGRCNSFDESADGFVRSEGVVVLILKRLSLAIQDGDQIYCVMKGSSSNVDGTFKKTNFFAPSKNAQSTNIKNAFLSSNGAMKYQDIDFFELHSTGTQVGDPIEVEAVADIFKNVKQEPLLIGSVKSNIGHLEPASGVASLAKVCLMFKHRQFVKNIHFNNPNPNIKFKEWNVKVCTETTAFPDRQVSMAINSFGITGSNACVLLSEYIKPSELKNQTSMKLNEKSKLLIPISTNSKKSLEQFKSKLLEEIDTYSESLTFEEFAMFQVYSKTTKLSQRSVLIGNDWNDLKIDINEIISTKNNKSGNIIKSNDINPPLVFSFCGQGPQYSKMGLNLYENEPIYKQSMDILDSILFKYFGYSIIQKLRSINDDPILINEPILAQPSIFMIQISLYKLYLHWGITPSIIVGHSLGEVASAFCSGMIDLETACFVIYKRATIQNKTNGSGRLLAISLNLEEFNNQFSKEYPEIEISCFNSPSSIVVCGNELDILNISKSLKDKQIFNSLLGTSSAFHSSKQDIIKDEIIESTNHIQSRPPSITTFSTVTSNKFDKNTPYNSSYIFDNLRKPVLFQQTIENIFKHIESNDLGNSVIFLELSPHPTLNHYVKEMIPKNSNYFLNKDSISVLSSLNKKKEDINEIQSTISQLYCFGYNVDFSAQFKSEITSNSFKKCSYLIPHYQWDESLFWREGISSLNNRKNGAPINQLGNKNESSPHISYTSYIDIKEEPFRFLKDHQFRGKSLFPGVGYLDIILKLFPNQDLTIPLLEFKSQFVLTEGVKKTLTTNLYKSAKNEYRATFNFKDQTSGKWIQSANSRILMKSLDVTVKKVDVQSIRDQCNWSTLKREQLYDLIKNYANISLLEPFQRIEEASYGDNRCLCKVSLDPTSSYDNESFLNICIIDTCIHPCIFFDNPASSVFERIEHLKIYSSSVPLTAEDRVKQQYVYCYAELIKQFSDFIYFKTTCFLKDGTVLLHSPLVTIASTLSTKSETDLECPNNQLFSQCLQPKDSILQSPLILKEHFNQQLQLQQSNIISISTLSTYLFSILKKRLNNLTVDEFQNNSLEQLIEKYSYVLDEVEVGTIRSNLILLTINFLLTHHKHIDQNQVSNFLLNNIPNELLVVDTIVSNKGISHIGIYQHQLILDIISKSIIPIVNEKIVFRILEIGCGVGELTKLINDNLESILNDNPSYNIDIEFVFSDYTDSKVLLIKERLFNSKKSCFFKIIDLNKQLQEQSFSPSYYDLIILSNTTNQIKDIKTSISFINEILTPNGHLLILDTNFIQTSIDEDYYLENYKQWLSFNYLNSGSGAMKLNQWNQLLINDLKFNNFICSTGEIEPYLIQVQKPNLSNSINSVSKEHTSEYDQIIIFGTCDEINIGSSFCGSGGVVPIAINSIDKFKEHAKLQPLTDKSLILFIESVNLLTVDNFNQVSMNYIEINQHLLKNEISGCKHILISRNINFETSNLFGSSLIGSFRYFCEFNQLNIYSFEFEGNNILSGGDKLFNIIQELSNSNKHSQNEFSIRSDGKIYYERIKLESNLKLKYKSKSYIENKNELVSRLKPDLTFALEAVLPLNPNFVEVKVMASGVNFKDFLVYRQLINMANSNENGDPSKPQFGYELSGIVTKVGKNVTKFKVGDHVMGVTFHTFSSSVHVDQDRIELKPSNISWFEASISLVYLTSYCSLFELGRLGLHGSTETVLIHSGSGGIGLSCIDLLQVYGFKGFLFVTVGSEEKKQFLKDRYGNFITEIYSTKNTDYEYLIKEKLIELKAPSQEYGGFSMICVDLIINTLSADYMDANFNCLSQGGRIIDLSITHMTTTDTTDFYKFKNHIGYMTYESVIAGFRKHKHVLKIIVDLLASGKLKTIPFNVYPVTKIKEAIESLGDRKHIGKNIVNFNDPEGIDLIDCPEFSNNHNFIHRSSNYKIHQDTLGQTILITGQAGLSDTIIKWIREKRSDSIESIIVLSKSPIKFELERAIGRIRSTNLKIYFKQVDISDEKLLLKTINQLFEENKDIKPIESIFHNAFSPAECEPLEIDMNHLISSHSAKSMGAYNLHKLSLNWPIKQFVLSSSVTSILGSQRQCGYVASNCFIDALSRHRKSLNLPCISINWGLLGGGGFAARNDAVFKLFELQGLVGISKDLVWGSLDLLLQNQNESTNKMVASFEFHATCKTYKNHKLSYKLDYFLNPIISKESVTDEKEFSIRQDIVDKFASLLSTDQSKLNLDIKVIDYGADSLLVVEVKNWADNKFTRNILSMPEIQNSTINQIINIVTTKVSNLPSKKK
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Homeotic protein controlling Drosophila head development. Transcriptional activator of the apoptotic activator protein rpr in cells at the maxillary/mandibular boundary.
Subcellular Localization:
Nucleus.
Sequence:
MSSFLMGYPHAPHHVQSPMSMGNGLDPKFPPLADDYHHYNGHYSMTASTGHMSGAVGGGAGVGSVGGGGAGGMTGHPHSMHPADMVSDYMAHHHNPHSHSHSHTHSLPHHHSNSAISGHHQASAGGYSSNYANATPPSHPHSHPHAHPHQSLGYYVHHAPEFISAGAVHSDPTNGYGPAANVPNTSNGGGGGGSGAVLGGGAVGGSANGYYGGYGGGYGTANGSVGSTHSQGHSPHSQMMDLPLQCSSTEPPTNTALGLQELGLKLEKRIEEAVPAGQQLQELGMRLRCDDMGSENDDMSEEDRLMLDRSPDELGSNDNDDDLGDSDSDEDLMAETTDGERIIYPWMKKIHVAGVANGSYQPGMEPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDANGNPTPVAKKPTKRAASKKQQQAQQQQQSQQQQTQQTPVMNECIRSDSLESIGDVSSSLGNPPYIPAAPETTSSYPGSQQHLSNNNNNGSGNNNNNNNNNNSNLNNNNNNNQMGHTNLHGHLQQQQSDLMTNLQLHIKQDYDLTAL
The following text describes a protein:
Function:
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Subcellular Localization:
Mitochondrion.
Sequence:
MAVAAVATVTIATSRTSLQVIPQTRLFPSQMPIFSTRRFFTSAKNAVESHTLTKVPAKSYYKTNVIDILKERGLLESITSENLRSASSSPLRVYCGFDPTAESLHLGNLLGIIVLSWFQRSGHKVVALVGGATGRVGDPSGKSLERPDLDLGTIEKNCAGIRGIVGRMLGSPREDCEESGDKIEEDSFVIVNNYDWWKDMNLLDFLREVGRFARVGSMMAKESVKKRLSSEEGMSYTEFTYQLLQGYDFLYMFKNMNVNVQIGGSDQWGNITAGTELIRKTLQVEGTAYGLTFPLLLKSDGTKFGKSESGAIWLSPSMLSPYKFYQHLFSVPDADVIRFLKTLTFLSMNEIQELEEEMQEPEYIPNAVQRILAEEVTRFVHGEIGLQEALQATEALKPGAETELSWATIERIAKDVPSCSLDYDEVLNTSLVDLSVRSGLLSSKSAVRRMLKQGGVYLNNKRVNSEDKVIQEVDIIDGKVILLSAGKKNKMVVRIC
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Recognizes and ubiquitinates BIRC2 and the cell cycle regulator DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. Mediates the ubiquitination and proteasomal degradation of UXT isoform 2, thereby impairing the NF-kappa-B signaling pathway. Inhibits NF-kappa-B pathway also by promoting the ubiquitinatioin of TRAF2 (By similarity). Affects the assembly state and activity of the proteasome in the cells including neurons by ubiquitinating the proteasomal subunit PSMA2 via 'Lys-63'-linked polyubiquitin chains. Promotes 'Lys-48'-linked polyubiquitination SIRT7, leading to the hydrogen peroxide-induced cell death (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytosol. Note=Predominantly cytoplasmic. A minor proportion is detected in the nucleus. Relocates from the cytosol to depolarized mitochondria (By similarity).
Domain:
The ubiquitin-like region mediates interaction with PRKN; The proline-rich region is important for protein-protein interactions.
Sequence:
MKLRVRLQKRTQPLEVPESEPTLGQLRAHLSQVLLPTLGFSSDTRFAITLNNKDALTGDEETLASYGIVSGDLICLVLEDDMPAPNLPSSTDTEHSSLQDNDQPSLAATPSQTNIPDEQGTDSSQGQATPFDAWTDDSMEGPSQNVEAESIQDAMSMEEVSGFHPLEPMLCNETEDGQVPHSLETLYQSAGCSNISDALIVLVHLLMLESGYIPQGTETKAVTMPEKWKSSGVYKLQYTHPLCEGGFAVLTCVPLGNLIIINATIKVNGGIKNVKSVQLQPGSYVAAGVEPGESAAKVYKDLKKLSRLFKDQLVYPLLAFTRQVLNLPDVFGLVVLPLELKLRIFRLLDVHSVLALSAVCHDLLIASNDPLLWRCLYLRDFRDGTVRGPDTDWKELYRKKHIQRKEAQRMRHAMFLPSAHPIPFCPIPVYPRAYLPTSLLPPGIIGGEYDERPILPSVGDPVTSLIPRPGELPGQFRPLRPRFDPVDPLPGPHSLLPGRAIPNNRFPFRPGRGRSADSRLPFL
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in autophagy in response to starvation.
Sequence:
MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSPSCRFASPPSLPDMQNIQEENLSSSPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNISSDHSYDMPMGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSSPPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSKILQDPADIENVHKYKCSIERRLSALCHSTATV
The following text describes a protein:
Function:
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPKRGCPFADAAPLQLKVRVGQRELSRGVCAERLTREIFEKTTQLLFRGAQAYMDHAWEEGCATVDLPESPKPGPTEAPRASRGQMLIGPDGRLTRSRAQASEAEPAGAASGACSSCVRAADGKAACGQCERALCGRCVHTCCSCGALACPLCAVVDCSNIQEKVLCASCAVFET
The following text describes a protein:
Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVRFKSRYLLCEVRMSDPPSLQLLDDRSVFTALRNAVSRAHGDYGAGVCGLSFAVKYLNARTGVLFLRCRKSHYRLIWSALPFVSSLESRGQRLPCAVDCLHVGGTIRTCQKFLIRYNARQIQRLLPQCRSEEECVEVRRAVMSCSLKELEEEEEEEDEERGEVSAGQ
The following text describes a protein:
Function:
Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MADVPGAQRPVPGGGPEPRDPLDCWACAVLVTAQNLLVAAFNLLLLALVLGTILLPAVTMLGFGFLCHSQFLRSQAPPCTAHLRDPGFTALLVTGFLLLVPLLVLALASYRRLCLRLRLADCLVPYSRALYRRRRNPQPRPARSSPGPQVAPTSGKVWV
The following text describes a protein:
Function:
Putative monooygenase that might be involved in antibiotic biosynthesis, or may act as reactive oxygen species scavenger that could help in evading host defenses.
Sequence:
MTSPVAVIARFMPRPDARSALRALLDAMITPTRAEDGCRSYDLYESADGGELVLFERYRSRIALDEHRGSPHYLNYRAQVGELLTRPVAVTVLAPLDEASA
The following text describes a protein:
Function:
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subcellular Localization:
Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal.
Sequence:
MLPFVQERIGLFIVNFFIFTVVCAITLLVCMAFLTATRLCVQCMTGFNTLLVQPALYLYNTGRSVYVKFQDSKPPLPPDEWV