lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for nuclear membrane fusion during karyogamy.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
Sequence:
MSLSYSFNTTIFTENRDLVAALQPQTNCARTALTLIVSDCGKLSSFNEDQQLRVSLAVGLAVCEFKAAQVTYPDACNNIEDWMSTSACTQQLVSSPQWWTTYHGCYNSVKQICHMHEASRECDRALKTHSQIVDMQEKLHTKMDQYWELVETMSDHRDAVLDYWNDTFDFMSETLAHMKETSVSLNAVYRDNFAQAQEHFQMLSENLQEARVQMENLGWAAQDAVVSLSKSTLAEQSLVSERLKNDASSLHKLLVLAHQDTTESFETQLQQSLTILVESSDNVLLNHVQQVSSRLSALMSDLEESQKKNMDMQHQLQQKVRTINDDIEGFTDTVKQGLEASHSLLNLVKSKIQLVNGVVSIFSRPVRSAFQLASFIIMIRAAFIGGIYTSIGLVMGSMLGVLVMQQV
The following text describes a protein:
Function:
May bind to RNA via its Arg/Ser-rich domain.
Sequence:
MSAPSNKMSATDQMRAMLDQLMGTTRNGDERQLKFSDPRVCKSFLLDCCPHDILASTRMDLGECPKVHDLAFRADYESAAKTRDYYYDIEAMEHLQAFIADCDRRTDSAKQRLKETQEELTAEVAEKANAVHGLAEEIGKKLAKAEALGEAGEVEDSMELMKEIEELRAKKIKAEHEYRTSMPASTYQQQKLRVCEVCSAYLGIHDNDIRLADHFGGKLHLGFLTIREKLIELEKTAAPRKAELKRTGKMTDREDEGRGRNRYFVGGRELDRRSRVHRSRSRERQRNRDGDRERPNNGRGPEEKGSERPKEAADGPERAERAPDRGGRRDDRDNHGRDHRERERDGRRDRDRHGRNDRGRFGDRGGGGGGGGHHRDDRRRSRSRERSPRERRNFNHFRDGGGGGNGQRKRSYSRERNYRR
The following text describes a protein:
Function:
A cysteine desulfhydrase that generates hydrogen sulfide, H(2)S. The H(2)S produced by this enzyme may modulate central metabolism; A cysteine desulfhydrase that generates hydrogen sulfide, H(2)S. The H(2)S produced by this enzyme stimulates respiration in M.tuberculosis, mediated primarily via cytochrome bd with a lesser contribution from cytochrome bc1/aa3. H(2)S modulates the balance between respiration and glycolysis, and also contributes to redox homeostasis. Probably eliminates toxic levels of Cys (which can induce oxidative stress).
Subcellular Localization:
Cytoplasm.
Sequence:
MSQRQWVAAAIQKIEADFNRSADTHLIPMDLPGYPGIDLYFKDESSHPTGSLKHRLARSLFLYALANGWLREGRPVIEASSGSTAVSEAYFARLLGVPFIAVMPASTSPEKIAAIAFQGGRCHLVERACDLDSASHQLARETGGHFMDQFTYAERATDWRANNNIAESIFKQLSEEPHPIPEWIVCSPGTGGTSATLGRYVRYRRHDTRILCADPEVSVFFDGYCRAVDGQCPKELAITGGSRIEGIGRPRVESSFIASCVDVMIKVPDALSLAAMRHVSATLGKRVGGSTGTNFVGVLQAAQRMRDEGRQGSIVTILCDAGERYAHSYYDPAWYVAREIDVDASDAAIAAAVAGAALPALPCAALE
The following text describes a protein:
Function:
Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGKDIRNHSKWFVFTLCFIVLLGPMNAVLFNVALEDIANDLSISQSKVSWVVVGYSLVVGIGSIIYGKLADRYSVKRLLIISIIIFVAGSIVGFVNQSYEIIIFARLVQASGGAAFIALSMIAVAKLVAPAKKPGALAMISSSIALAVGIGPLVGGAITNTLGWPYLFLFMVISMIGIFLLVKFMPEEARHTDEVFRFDFIGAVLLFVLITTILLGVNINSWLFVLSVVFLFLFKAHMKRTESPFIDIELFTNKPLLRLIAVGFIINVALCASLLLLPLLLGRGHGLSPFVIGIVLFIASLFGIVSSFITGKIIPSFGNVKMMYVASVVMIIGFLILGIIPDGNLLFILFAVILTFMSYSAIQVSLNTFIPKTLNPAKVGVGLGLYNLINFFGMAFGPAVASKIMESTNSYRLNFILIVILIAAHFFLLMGMSSFQKKMEQ
The following text describes a protein:
Function:
During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Enriched at the nucleus-vacuole junction. During endoplasmic reticulum (ER) stress, localizes to ER-Golgi contacts (By similarity).
Domain:
The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.
Sequence:
MTSLYGRHAEKTTDMPKPSAPKVHVQRSVSRDTIAIHFSASGEEEEEEEEEFREYFEEGLDDQSIVTGLEAKEDLYLEPQVGHDPAGPAASPVLADGLSVSQAPAILPVSKNTVKLLESPVPAAQVLSTVPLAVSPGSSSSGPLASSPSVSSLSEQKTSSSSPLSSPSKSPILSSSASTSTLSSAKPFMSLVKSLSTEVEPKESPHPARHRHLMKTLVKSLSTDTSRQESDTVSYKPPDSKLNLHLFKQFTQPRNTGGDSKTAPSSPLTSPSDTRSFFKVPEMEAKIEDTKRRLSEVIYEPFQLLSKIIGEESGSHRPKALSSSASELSNLSSLNGHLESNNNYSIKEEECDSEGDGYGSDSNIPRSDHPKSTGEPTREIELKSSQGSSLKDLGLKTSSLVLEKCSLSALVSKEDEEFCELYTEDFDLETEGESKVDKLSDIPLKPEVLAEDGVVLDSEDEVDSAVQHPELPVKTLGFFIMCVYVYLILPLPHYVSGLFLGIGLGFMTAVCVIWFFTPPSAHKYHKLHKNLRHWNTRSLDIKEPEILKGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEVTYISQKIYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQILYLFGRTGREKEEWFRRFILASKLKSEIKKSSGVSGGKPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYSVYMGRCVPQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTLTELDMGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAGSSEEDDAPEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVWYGFRKPPHVELKARPKLGEREVTLVHVTDWIEKKLEQEFQKVFVMPNMDDVYITIMHSAMDPRSTSCLLKDPPVEAADQP
The following text describes a protein:
Function:
Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Nucleus.
Sequence:
MIPVSLVVVVVGGWTVVYLTDLVLKSSVYFKHSYEDWLENNGLSISPFHIRWQTAIFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSSYSSSSSSSSSSSSSSSSSSSSSSSSLHNEQVLQVVVPGINLPVNQLTYFFAAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQLRIFCAAMASNEDFYITQDPEIPADIVGLHDINVEPLPMVDIPMESIQYEDVDGNWIYGGHNHPPLIALQPLFMNTGYGDHDQEMLMVQTQEEVVGYYGSDNLLGNDLEDQLAIPDSTEDEHFQLTLASLSASAASTSTQSRSKKRSKKPSKTPSSKSATSAEATPAGSSSNEGRRKWEQKQVQIKTLEGEFSVTMWSPNDNNDQGAVGEGQAENPPDYSEYLKGKKLPPEGLPGVDLSDPKQLAEFTKMKPKRSKGELPKTVPCSHSGCEKMFRDYAAMRKHLHIHGPRVHVCAECGKAFIESSKLKRHHLVHTGEKPFQCTFEGCGKRFSLDFNLRTHLRIHTGDKPFVCPFDICNRKFAQSTNLKTHILTHVKSKNSP
The following text describes a protein:
Function:
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
Sequence:
MNNIIQLLETEQTQGKEIPDFRAGDTVTVQVKVKEGNRERLQAFEGVVIARRHRGLNSSFTVRKVSHGEGVERVFQLYSPLIASIKVNRRGDVRRAKLYYLRNLRGRKAKIKEKI
The following text describes a protein:
Function:
Antimicrobial peptide. Has strong antibacterial activity against the Gram-positive bacterium C.glutamicum (MIC=0.4 uM) and the Gram-negative bacterium E.coli (MIC=12.5 uM). Has weak antibacterial activity against the Gram-positive bacterium S.aureus (MIC>50 uM) and the Gram-negative bacterium P.aeruginosa (MIC>50 uM). Has antifungal activity against S.cerevisiae (MIC=12.5) and C.albicans (MIC=6.3 uM). Has weak antifungal activity against the mold B.cinerea. Presents chitin-binding activity.
Subcellular Localization:
Cytoplasmic granule.
Sequence:
MRVLLILVSLAALAHAESFLKSKTGYQGVQTLPGFIGGSQPHLGGGIGGGRPFISQPNLGGGIGGGIGGGKPFIPQPNLGGGIGSTRPFPRPQYGDYGSRNSCNRQCPSTYGGRGICCRRWGSCCPTNYKG
The following text describes a protein:
Function:
Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum.
Subcellular Localization:
Cytoplasm.
Sequence:
MTMPESMLSESKLSGWAISPKLAQLASLAGHYADPEFSVAHGGHVRTIAAGHYTVSGLSRHVRLGEFVAHRSATGIHLGEVVRVEPDICYVCPIEPGEPIGIHDTVIRKGAFRVSPDESWCGRTINALGEPIDGQGPLASGIVRRSISNNAPPSMTRKRVETPFKTGVRAIDIFSPLCLGQRLGIFAGSGVGKSTLLSMLAKADAFDKVVIALVGERGREVREFIEDTMGDNMSKSVAVVATSDESPMLRKMAPLSAVTIAEHFRDQGDNVLLIIDSVTRFAHAIREVAVASGEPPVARGYPASVFTELPRLLERAGPGAEGTGTITAIVSILVDGDNHNDPIADSTRGILDGHIVLDRSLAEEGRYPPINPLASISRLAKKAWTPDQEKLVSRLKALVHRFEETRDLRLIGGYRPGTDPDLDMAVKQVPIIYETLKQLPDEPAAQDAYADLATALRGGAQNGQPQVNPRMRG
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEGGGEKLQRSRDLGSRRKTTAKATPVKVSVTFDDVAVYFSKNEWKKLEWSQKELYKYVMRTNYETLVSLDYTIPKPDLICQIEQGKEPVFKNLANLETSVRIIQSGRDELSNSNNTEEQESATAELCNTNSSEEQESDADELCNSNSFEKQQSIDRNQRALQLNAKEHHSNGSRNQYLSGSSTLKERDVFCRPDQRNTLRNLSSQNSQSSISETNSTTRTTERVEEENPRTVSCQEAPSGHRFYPCHVCGKSFQFKGHLVKHQRNHSDNQCQCEKCKKKFSRHSSHRQKGKNKRKGRNKKRFECNECGKSYCQKRSLTAHQLKHRMEGFLQGSERNKNFTRRVNPKRTERTTRANVFTCRECGKSFCQESYLRTHLSLHKEEKLFICGECNKCFSYQYKFIEHIRVHTGEKPFQCTKCGKSFRLKVSLKIHLSMHNGIDPYRCSECKKNFACKSSLVKHIRRLHRLDRPFKCPECDKTFKRKTTMRLHYSLHRGERPFPCTKCDKCFSQQIKLIEHLRVHTGEKPYQCPECGKKFRLRRNMVAHESEHSGMKSFICGECGKRFLMQYMLTEHFRVHSGEKPFQCGQCGKNFTRRTNLNAHMRIHTGEKPFSCSQCGKCFPHHSKLAQHLQVHNKEKTFQCPECDKSFRQNRSLKAHMSKHNGEKPFTCKECGKSFALQHVFNEHIRVHSGEKPFQCPECNKSFYRKATMKVHQRRHKQKKSYPCPKCEQYFSQRCELTEHAKTHKEKAAFQCSECDKSFSQEKSLKVHESLHKAGMTLSCDECGKNFTRKCELSRHINNHCRKKFFQCPDCKKSFAHKSSLRAHHHVHKKDRPFLCSDCGKSFAYVGAFNTHTATHAKERAKSSRSEKNSMLQKSFRSEKNSTSEKSSGSQKSSESEKSYKSVVIVSSANSLNHKS
The following text describes a protein:
Function:
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MTLRFAIPSKGSGYEATVALLESCGLRVTRANPRQYTAVLRGLPDTEVLLHRPADIVLKVAEGAIDLGVTGYDLLHELRGDDDDDVLTIIDDLGFWRVELVFAVPQSWIDVTSWADLADLAVEFQSRGRRLRIATKYPNTVRRFCYAQGINVFELVESQGATEAAPSLGYADIIADITETGTAIRENQLKIVGGPLIRSQAILIGSRRALRGNRHRLELVRQLCELIEARRRGRLFYSLTANLPGASVEEVGRKVTARHELAGLQGPTIAPVWSKFSGDSGWYAVNVVVPQEELLPAIDYLRAIGASSVTTVQVQHVFRAESEAFARLCARLDEE
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
MNEEKRARVGDTAETPRKSPRLDRPAAAAAAAAPLTSNGVMGEKKKKNATRDVSDWCWWGKAAALLSGGDRRTRRCRHVLCEQADIDVAITLIKTRVDTPVCCVNKCDDTEGREISVCLDCQLSFCTAHGKPHVFMNDHWIALVYKRPNVAHCFACEECYFIRTDSLGEGMAVGENGFSIGTHKKDEKGMTTVNNEAGVHASMVSDYESALMVALLSDVGTPRCRHDMYNKDEVDLVQRRIMFCDITRMCSDCDNISVLMIFVCLGCEKPFCTVHSSLHAESTKHLVGLVYHNPYVACCFLCSETFVLIGEGDKRMPVDKAAGGYASESVIGHAHAIKGIPNLGNTCYLNSLMQCLLVLGKLRARMLGPDAPSGTLGTALHDLFEQTYSVNNATGLLETSLLLDCVCNLDPQFVGGFMHDNHELLCCLRKNLDEEERMRTPPNMQDSSAGAVPPTVFNSIFGGQLFVTRSCKCCSFCSVSHAVFYDLSVPVPPKKPPAKSVESTPWIEGHRSQPKICINQFEAIHKRNTEKTHRIVEDADSDPASELKDMVMVKTSEPLEVDYTEVEQISQSKDYVQDPQNVLADVKTAGMDATTTDTRIPEYIGPHPPVSQLREENAQLESCNDVGKDGNAILEVSSEHKIDTFSAEVTTEDKGKTCSSDVVCGKAQDIDSLPSITKMIEWTCENCSKGARKSDVTEGTYSEQMLSSTNEDTAVGGYQREQSEKITCQSEQSNKKPECPEGVQDAVPHCVPAERQDNLLSSQDQNATTLDEGRGKQKLHHSAHQVEECQNEQKDRNKGATQTRISKLPLVLTIHLMRSLLGPDKVMGHVSFKEILDMGLFMDPSSEDKDNSIYRLAGVIEHHGRGKDSGHFVAYVRPSPRQQTNGSSSWFCASDTDIREVSLEEVLKCEAYLLFYERMEG
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
Miscellaneous:
MISCELLANEOUS: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.
Sequence:
MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVDTMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAMYEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTGEIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSDGLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEEWEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MNNYHIYETIGRGKHSVVYKGRKKKTIQYFAVKSVEKLQKPKVLQEVRTLHSLEHENVLRFHAWYETSNHLWLILEYCVGGNLLTLLHQDTRLPEESIHDFARDLVKALQFLHSNGVVYCDLKPSNILLDENGRLKLCDFGLARRLSDIQKFSLQQLPQAKRGTPCYMAPELFQEGGVHSFASDLWAVGCVLYECATGQPPFVSNSFTQLVSAILETPLSPLPASVSPEFADLVQRLLVKDPVHRISWPELRVHPFWRVPTKELPLPEQPAFDHFLRQRRAGEAVSLPPLRGATPPVASGGAEKAGGEGGGSRVTALPELAGAQRPGSARKAGDVNVLRLSQIVQKNFRREADGGGYRQGGEEGGAHSDVTLENNDIEIDLAEEGAEGGEDEGEDTSGAVEAAAAAEGVKMPLSREDSSALNTERFPRGGTPEPHRPDDTAPLSARTGSKTSAGGSGDSRRGPPTPDESPDDSSSDGVESAVQQVAQSQLLWHQLDLAVKPIVLNRRIEKVQEPTFDPRALPVEPLSGAALAQAPPDQSEAFLARIMASISGATSLNEKLNTLSYVETLATETDAANHLINSQLMPLLVRMLKISKPPVLRAKLASAMGLLVRHATVIDEDLAASGIVPILTEAAKDKQERVKRRAIASLGELLFYIATQSEQSPKAANSPPAWEVPEITFTAVGSMLRRGEDEVAQHYAVKTMENIASQGGAWASKFASGETVANLVFIFQNSKLEHLRATAGSCLVRLARFHPPVLPAALEKLGVRALVRGLAEGSSKTQQTYLNLLNMGLQAGVRIGATRLQTQLMAEERGLVPTLVGLLEHASEVLRAKALVAGWALCQASTRWLVALCNAKVTSVLERLARDRDEYVQRCLEAFLSLVAAMALPILDQARAELSKLATKQGRATPSASPRTPPSGSRGPLGQAAVLLHLVTCQLTRSRFADGRLLSLLGVCLARSQDALVALDASPSNSPRAPKDAPAPGPASPLALVAEFQSVVLQILEALSQGQTPTVLGHKEATVQQVLPVLADLYRASKDGDRRFMCLKDEEPIPTYAQKLLALLLDRQCVRIPDLLQLKLLPRLFDFLAGDPETINSFALKLCLAAISAPEVPTRALSEARVCARLGLLLQDVAGQGKDDFVEPVVAICRGFLERHAAAQGRGGGAGIQDIAELALSSDVFLALVGSHEDSVADAASHCVALLSVAAPRSIGGALLQNVPQVLQVLETANKCQSKALLAKIQHRLLSALREACKQQRSTAGPSSFNMSNVEQLETLIARLRRSTSSSVTQAANDLAAELARVIAR
The following text describes a protein:
Function:
GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2. Controls access of pre-ribosomal RNA intermediates to RCL1 during ribosome biogenesis by binding of RCL1 in a GTP-dependent manner and, via its affinity to U3 snoRNA, delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MEQSNKQHRKAKEKNTAKKKLHTQGHNAKAFAVAAPGKMARTMQRSSDVNERKLHVPMVDRTPEDDPPPFIVAVVGPPGTGKTTLIRSLVRRMTKSTLNDIQGPITVVSGKHRRLTFLECPADDLNAMIDIAKIADLVLLLIDGNFGFEMETMEFLNIAQHHGMPRVLGVATHLDLFKSQSTLRASKKRLKHRFWTEVYQGAKLFYLSGVINGRYPDREILNLSRFISVMKFRPLKWRNEHPYMLADRFTDLTHPELIETQGLQIDRKVAIYGYLHGTPLPSAPGTRVHIAGVGDFSVAQIEKLPDPCPTPFYQQKLDDFEREKMKEEAKANGEITTASTTRRRKRLDDKDKLIYAPMSDVGGVLMDKDAVYIDIGKKNEEPSFVPGQERGEGEKLMTGLQSVEQSIAEKFDGVGLQLFSNGTELHEVADHEGMDVESGEESIEDDEGKSKGRTSLRKPRIYGKPVQEEDADIDNLPSDEEPYTNDDDVQDSEPRMVEIDFNNTGEQGAEKLALETDSEFEESEDEFSWERTAANKLKKTESKKRTWNIGKLIYMDNISPEECIRRWRGEDDDSKDESDIEEDVDDDFFRKKDGTVTKEGNKDHAVDLEKFVPYFDTFEKLAKKWKSVDAIKERFLGAGILGNDNKTKSDSNEGGEELYGDFEDLEDGNPSEQAEDNSDKESEDEDENEDTNGDDDNSFTNFDAEEKKDLTMEQEREMNAAKKEKLRAQFEIEEGENFKEDDENNEYDTWYELQKAKISKQLEINNIEYQEMTPEQRQRIEGFKAGSYVRIVFEKVPMEFVKNFNPKFPIVMGGLLPTEIKFGIVKARLRRHRWHKKILKTNDPLVLSLGWRRFQTLPIYTTTDSRTRTRMLKYTPEHTYCNAAFYGPLCSPNTPFCGVQIVANSDTGNGFRIAATGIVEEIDVNIEIVKKLKLVGFPYKIFKNTAFIKDMFSSAMEVARFEGAQIKTVSGIRGEIKRALSKPEGHYRAAFEDKILMSDIVILRSWYPVRVKKFYNPVTSLLLKEKTEWKGLRLTGQIRAAMNLETPSNPDSAYHKIERVERHFNGLKVPKAVQKELPFKSQIHQMKPQKKKTYMAKRAVVLGGDEKKARSFIQKVLTISKAKDSKRKEQKASQRKERLKKLAKMEEEKSQRDKEKKKEYFAQNGKRTTMGGDDESRPRKMRR
The following text describes a protein:
Function:
MAP4K component of the MAPK pathway required for the mating pheromone response. Phosphorylates histone H2B to form H2BS10ph (By similarity). Phosphorylates tea1. Required for skb1-dependent mitotic inhibitory function. Regulates microtubule dynamics and cell polarity.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes at cell ends, septum forming regions and at the mitotic spindle.
Sequence:
MERGTLQPRKKAPNGYGITPIVAHKTGEPVRYEVEDDLRKLKPSRTAPKPPAINTNLAEDTFSGFPLSQSRTTVSRVSLGSRQHSSSSIRKLQTNVSDVRSYDERNQKKSAFENFVSSMSSFLTGGGSSPTSSYGSGSASPRKSTVISSPFDPKHVTHVGFNYDTGEFTGMPTEWQALLKVSGITKSEQVQHPQAVLDAMAFYSQSKKYLEEGAKPPFPRESTEKPLLSVSALSSSSHLQPTSATSSSSRLYPSRPAPTPPASSSSSPLLSSQTVKTTTSNASRQPSPLVSSKSTDNIIRSHSPVLLTPQTLSTSETKHIRPNNSTPYQRRAETSTKPKAVATPQKVEAPSAPRLQKRAPRQQSNDSAVLAKLQSICNPKNPTLLYRNFVKIGQGASGDVYSARQVGTNLSVAIKKMNINQQPKKEFIVNEILVMKSHHHKNIVNFIDTFFYKSELWMVMEYMRGGSLTEVVTNNTLSEGQIAAICKETLEGLQHLHENGIVHRDIKSDNILLSLQGDIKLTDFGFCAQIDSNMTKRTTMVGTPYWMAPEVVTRKEYGFKVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATIGTPKISRPELLSSVFHDFLSKSLTVNPKQRPSSGELLRHPFLKQAVPVSSLIPLIKSIHHSGK
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MVSFRTMLKSFSALTLATRGVSLATHGKPIIAVPKLGPYALFLKDNAAKSSVKINKTSIAGFGKETAAKWKALSEPEKKSYSKRAQEINDKAMADFLKKPEKEQLKLEAEARDAKEKLAKKRERRERRENWEKTGHPKMPTNAYLLFVKEKMNQVTKVSSKEEAASRVKALAEEWRGMTDSAKAKYVKVAEAQSEKYKIELEKWKKSNPEKKDAPSKKTTMMKLAIACALFGLVVFSSIVEAEEKKLQIGVKKRSEKCEMKSKKGDTMHMHYTGTLEDGTKFDSSRDRDQPFTFTLGMGQVIKGWDQGLLNMCEGEQRRLTIPAHLGYGERGAPPKIPGGATLKFDVELLKIERTGEL
The following text describes a protein:
Function:
Induces paralysis 5 minutes after injection into blowflies (L.caesar), and then death within 24 hours. May have antimicrobial properties, like most ant linear peptides (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MKSVILLFAVIAIIVAVIIPAINGESSSNPSANAGIMESLKQLSAKAEELIKKLLAKKAK
The following text describes a protein:
Function:
Catalyzes the synthesis of activated sulfate.
Sequence:
MSTMGNSTNIFWQESPVGKLERQKLLNQKGCVVWITGLSGSGKSTLACSLSRELHTRGKLSYILDGDNVRHGLNKDLGFKAEDRTENIRRVGEVAKLFADAGLICIASLISPYRKDRDACRAMLPDAFIEVFMNMPLALCEERDPKGLYKLARAGKIKGFTGIDDPYEPPLNCEIELNQKDGVCPTPSAMAEEVVTYLEDKGYLQD
The following text describes a protein:
Function:
Methyltransferase involved in methanogenesis from methylamines methanol pathway. Catalyzes the transfer of the methyl group from the methylated corrinoid protein MtmC (MtmC1 or MtmC2) or MtbC to coenzyme M, forming the substrate for coenzyme-B sulfoethylthiotransferase.
Sequence:
MAEYTPKERLYRALRKQQVDRMPAVCFTQTATVEQMEACGAYWPEAHSDAEKMATLAEAAHTVVGFEAVRVPFDITAEAEFFGCGIKAGDLKQQPSVIKPSVKNLEDLEKLKNYNLKEGRIAVVLEAVKILSEKYGKELPIIGSMIGPFSLAQHINGDAWFGNLFTGEEVVPALLDFCSDFNVAYAKAMVENGADTIAIIDPTASYELIGGEFYEKYALPYQKKIVDAMKELDVATVLHICGNTTNGLGIMDKTGVNGISVDQKVDIKTATGSVKNAIIVGNLDPVAVLWNGTPEEIAEASKKALDAGVGLLTVGCGTVSMTPTVNLQKMIECAKSHTY
The following text describes a protein:
Function:
Dioxygenase involved in phenanthrene catabolism by mediating cleavage of 1-hydroxy-2-naphthoate.
Sequence:
MNSSNTGAPEAAQAATLEAFDRRAAEQYLRGQWIAEEHLMRAIGGPRPAGIPYRWEWKSVEVALDEATIALGPVDTARRHLTFVNPGLMDRGSATTHTISAGFQLVKPGEVCWSHRHTMSAVRFVTKGHPDAFTAVDGERLPMEDFDLLITPRFSWHDHHNSGDADVVWLDGLDIGLLQSLGAVFYEPYGDDSQNVRPSSSEGIGTRSHWLRPTWERGRESRLPIRYPWKEVNARLDVYDLDAGTPYDGLALRYANPVTGGPTMATMDCWVQRLAPGFDGKSHRRSSSAITYVISGSGTMVTEDETITFNRGDVISLPNWTNFRWTNDSEIEPVLLFSMHDIPALEAFGLLYEEPEAILNATPAPINPTPSLNPIYRPGAFYDQDEL
The following text describes a protein:
Function:
Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis.
Subcellular Localization:
Mitochondrion matrix. Note=Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly.
Sequence:
MGALRVLRYVSMIWRPELGSCARQRDAGFGTEARRPSQPHRSSKHKDLVEDQPFPGLLRTENLGLEELAHVLRAAVVDQKGPLVTLNKPQGLPVTGRPGELTLLSVLPQLSQALGLEHQELQVVRAPGKEASGLVLLSSCPQTASRLQKFFIHSRRAQRPTATYCAVTDGIPEPSEGTVCMPLKMEQMNDVDLAVPVMSPSRKDIQEGVKRTLSRFHVMATGRGCALVQLQPLTVFPNQLQVHMALQLCPILGDHTYAARVGTVLGQRFLWPAETTKPQRQVLDEALLRHLRLSPSQVAQMPLHLHLHRLLLPGTGSRDPPSELLAPLPPYFSRTLQCLRLSQQ
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MARVIEIAPSSICCPVIPDVKKYVQEKGGMQQAIQSIEDTYKNLKFFLDVVSQRKTTLIEKVDETQSTLKYVILLEEKTNDQVKTKFEISNGLYLPVTINKPKTVNLWIGANVMMEYSFDEAKKMLNENIKTTQDHIEKLENDRKHLTTEISKMEDLIKQIVDASIALQKK
The following text describes a protein:
Function:
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Plays an important role in maintenance of endomembrane homeostasis including endocytosis, vacuole formation, and vacuolar acidification processes. Required for development of viable pollen. Might mediate recycling of auxin transporters.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein.
Sequence:
MEDPNKTFSDVVKLLTSWLPRRSNPDNVSRDFWMPDHSCRVCYDCDSQFTIFNRRHHCRRCGRIFCGKCTANSIPVSSGPDRNVDEGDRIRVCNFCFKQWEQERVTSLKPVLPVLTPSLSETSLFSTKSAITINSVTTTAGSYSNGNYQHVSCVTSTSPPKCCHDKTSHNMQDTHAPEKCMSTVSNKDDSSVQFGYYTNRSDDEDEEYPAYCSDRQVQHQQQSGQYYGPDEFYELDTPYNSKMSIVEESMTSKELSPHVLDQGFPSAPTITKSDNEPEHYYSSECGAASSIYALESNDTNPVDFEKDELFWLPPEPEDEEDELQAELFNDDDGDDDDDKSVADGEWCRIRSSSSFGSGEFRSRDRSGEEHKKVMKNVVDGHFRALISQLLEVENIPLHEGDDMGWLEIVTSVSWEAANFLRPDTSQGGGMDPGGYVKVKCLACGHRNESTVVKGVVCKKNVAHRRMTTRIEKPRLLLLAGALEYHRVTNQLSSIDTLLQQETDHLKMAVAKIVAQRPNLLLVENSVSRYAQDLLLEKNISLVLNIKQPLLQRIARCTGAQIVPSIDLLPSQKLGYCELFHVDKYDEQSVSSVNVSKKMVKTMMFFEGCPKPLGCTVLLKGGSMDELKKIKHVVQYGIFAAYHLALETSFLADEGATLPELPLLSPLTVALPDKRSTADSSISAVPGFTINVSISQQTDSFDHIGTDYIMSTQPGENAVAEAPVSSECFSSQNTYSHSLGPWCANNSNFNNGTGDGDGLANVTATPNSVSISSLSTSGALTNHTSRYSSVEKNSMHFGDYHDGSMRLHGKTVTIDSTSTASHYHQSTVKASTNINVNESLEGPYALANVKTINENNSIVVQPVSTAAVQYQETSQGDDSTSNKDEVVPSDHQSILVSLSTRCVWKGTICERSQLLRIKYYGNFDKPLGRFLRDYLFDQGYQCRSCDKPPEAHVHCYTHRQGSLTISVRKLTEFVLTGERDGKIWMWHRCLKCPWSNGFPPATQRIVMSDAAWGLSLGKFLELSFSNHAAASRVASCGHSLHRDCLRFYGFGKMVACFRYAPISVHSVHLPPHKLDFGHQPLDWIQKEANEVIERAKHLFDEVLHALHMISDKKVQGSSINMEFSNYIADLEIMLRKEKSEFEGCLNKVLRRDMQKGQPDILEINRLRRQLLFHSYLWDKRLVFGARSDRCRHEKTHSIDSVAEQNVILKPQSECSGNRSANKDAKYVECLQESIYGGNHTGVDVGTVNSNHVHQMATGELDSLQRDIKAPLYSSVSVNGESIPLEPDLVARRTLSEGQFPSVLDVTNALEAKWTGKDDPVSSKVTMPESTASSEDSEEHMGDNTPSYASILLSKLGDSAADHSNWIEMPFLLFYRSLNKQWNRSNRFDALNEYSPEYVPFLREVERHIGPKFFFPIGISDTVVGVYDDEPTSIISYALASHEYHLQMSDELEREMTDTSLPLCDSRSVSLTELDECTSELLRSVVSTEDIILSMSGRKNPLASDSLVPRKVSHIKVNFGDEGPLGQVKYTVICYYAKQFDALRRLCCPSERDFVRSLSRCKKWGAQGGKSNVFFAKTMDDRFIIKQVTKTELESFMKFAPDYFKYVSESICTGSPTCIAKILGIYQVKSLKGGKEMRMDVLLMENLLFERDVTTLYDLKGSARSRYNPDSNGSDKVLLDQNLIEAMPTSPIFVGNKAKRLLERAVWNDTSFLASIDVMDYSLLVGVDEKRHELVMGIIDFIRQYTWDKHLETWVKASGILGGPKNVSPTVISPKQYKKRFRKAMSAYFLVVPDQWSPPVVIPSKQAESGQDRDEQVVLTEL
The following text describes a protein:
Function:
Member of the two-component regulatory system CreC/CreB involved in catabolic regulation.
Subcellular Localization:
Cytoplasm.
Sequence:
MQRETVWLVEDEQGIADTLVYMLQQEGFAVEVFERGLPVLDKARKQVPDVMILDVGLPDISGFELCRQLLALHPALPVLFLTARSEEVDRLLGLEIGADDYVAKPFSPREVCARVRTLLRRVKKFSTPSPVIRIGHFELNEPAAQISWFDTPLALTRYEFLLLKTLLKSPGRVWSRQQLMDSVWEDAQDTYDRTVDTHIKTLRAKLRAINPDLSPINTHRGMGYSLRGL
The following text describes a protein:
Function:
Contributes to normal sperm motility, but not essential for male fertility.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Mainly nuclear. Also detected in cytoplasm near the midpiece of the flagellum.
Sequence:
MWKLSRSRVLLDEPPEEEDVLRGAPPASAAAPASGASLRGWKEATSLFNKDDEEHLLETSRSPKSKGTNQRLREELKAEKKSGFWDALVLKQNAQPKKPDQIEGWEPPKLTAEDVVADHTEDDRSGCPPWSAWEDDTKGSTKYTSLANSASSSRWSLRSAGKLVSIRRQSKGHLTETCEEGE