lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. Binds the protein phosphatase 1 catalytic subunits gsp-1 and gsp-2, which has a role in delaying formation of load-bearing kinetochore-microtubule attachments. Required for the recruitment of spindle-assembly checkpoint components bub-1 and mdf-1/2 to unattached kinetochores. Binds microtubules which plays a role in silencing of the spindle assembly checkpoint, but not the formation of load-bearing microtubule-kinetochore attachments. Has a role in the correct localization of the spindly-like protein spdl-1 and the RZZ complex that is composed of rod-1, czw-1 and zwl-1 to kinetochores.
Subcellular Localization:
Cytoplasm, cell cortex. Chromosome, centromere, kinetochore. Note=Also found on the surface of chromosomes. Subcellular localization dependent on expression of hcp-3, hcp-4, knl-3 and knl-2. During anaphase of meiosis I, localized also to spindle-associated rod-shaped structures which depends on zwl-1.
Domain:
The N-terminus contains a number of repeats which contribute additively to bub-1 recruitment to unattached kinetochores. The repeats are not required for localization to kinetochores.
Sequence:
MSMEPRKKRNSILKVRQAVETIEETVMNSGPSSTTTNRRVSFHNVKHVKQYDRDHGKILDATPVKEKITDTIGSDGILTPRGGNMDISESPACTSSFQVFGGGNLDKTMDMSLETTINENNETARLFETTRDPTLLYEKIVETTTKVTERIVSMPLDDTLAMFNTTNQEDKDMSVDRSVLFTIPKVPKHNATMNRTIPMDLDESKAAGGQCDETMNVFNFTNLEAAEMDTSKLDENNTMNAIRIPINSNVMPVDMDITEHHTLIEEKKNDTFGPSQLMDISAPQVQVNDTLAIFNSPRDICNKGLGVPQNLINIASNVVPVDMDITDQAVLNAEKKNDQFETSQLMDISIPKVLVNDTMAMFNSPKHVSKSSMDLEKTIEAADKSTKYPSIADEVEDLDMDMDITEQQPCEAGNQQNDGLQLQKEDLMDISVIRDSPAVNDTMAVFQSPARVKIGANNSIIDSQKSIVFGDEMSIDETQNDGTLTLPKSNVEVTTTNDVYTSLERQEENASENVSMINESSVHSEIDKKSFMLIEEERAFMHSSMIDVAQKLEDDGSSKTPVILASQSASLATKEPSALHNSSATLNNSMELDNNTLLKTMQITTCEDISMVHESIAVELNSNKEQEQFGDETLQKNDTSNTGANFTFQGHNETSQIMNNVDSEAVNTSKISTYSAFNLSINQSISKRRRSLLNSARESPRRVALENSIMSMNGQTMEALTEYRQNKTMQTSQDSMPSMSLNDSGRDILAMNTSVRSPHLNSSKTAAPGTPSLMSQNVQLPPPSPQFEMPDFDPAVVNVVYLTSEDPSTEQHPEALKFQRIVENEKMKVQHEIDSLNSTNQLSAEKIDMLKTKELLKFSHDEREAIMIARKDAEIKFLELRLKFALEKKIESDQEIAELEQGNSKMAEQLRGLDKMAVVQKELEKLRSLPPSREESGKIRKEWMEMKQWEFDQKMKALRNVRSNMIALRSEKNALEMKVAEEHEKFAQRNDLKKSRMLVFSKAVKKIVNF
The following text describes a protein:
Function:
Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase.
Subcellular Localization:
Nucleus.
Sequence:
MSNADQHMDVDEDEYLYGETIEERNDGVTVSNAKSPEQASEESDDSDIEFIIETKPGERAEPLGGSIATLGSTRPSAKPQVEKTAVEVKTTEPQDLSTAETAPKVDIDAVPTIDGKNIFEIDLESFDDKPWRKPGADISDYFNYGFDEFTWAAYCAKQTTLRDDFSPQKFMASLAQIPGPLPSGNVPSPAEFQAMMASGFPPFMPIPPPIGGPQEDMGYSRNFPVHASSNYNTTHTSGGGVHSGAATPNAYVNNNPSSSRRESESPANSPNITSSAGMTHAQPTHNPTSSYGNGASTNYNASRPPSNHPHSSNYPSSSRRKPSPDRYSNYSSRGSGGRYRRNRY
The following text describes a protein:
Function:
Required specifically for chromosome disjunction during all mitoses; maternally provided protein is sufficient until mitosis 14 then zygotic protein is required. Involved in formation and/or maintenance of epithelial structures: bud extension during Malpighian tubule development, and foregut and hindgut morphogenesis (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSADIVKQLKGTRSDVKAAATTIELKFKEFSKGIGINDASFPLRYELSVLRQLCLALKDNLHQHADLYCGIAATMLPHVEPYEEKPSLWEAHLTSLRYIHHGLCQEKSLTECQKMYGLIRSQPCRLQEEADYKFYLDIHLTHFNGIYLQMQKETLPLAATDELYYALEAMGVLFDTMHQRKVAKNAALLVQLNDSLFSKRSKAFLKYLSALPPESTTKMYDPLLKLLSCSWATPSSELTNQFTEYLGLVLALVQIDMFSIEAPLEQQLALKLLRICRDLYKDVSPQNYSIQLLYYYVKLMYVREATADFKQTYIDLCKKFVYFFEHKGATHAKEQWFMDLLVFFQRLQTLLHQSSNKPPLDIFWQQLEGDDSSEVYTAHFQLLHGCLGLAVNVVRSPLGTSCSNEACKSIRRHCLLYFGMCALEAYINWQPTTEQKADKAPYKPLLGILGYTLDVAKSMKCLGPSAMELVKLVRLLALVAEKVSCPEQMSLVLAFLEPLQHLRPLIASQDMLSVLRRIYKASVHCKSSDMANRLQSTYLAALTNPSRLRSQLFAHYHNANNTEKCVYEWHESSPMPNPLTPAQTKQLYDVDLLAVLHFLSAPPVPLLQSLLRCRHNDYHLALLARKMRTDSEVVRQCEELRSQLHSTALKQPLSRMQQLAIGHTSISVLLEALEAQKTKFSIKETAENCLEELIVKNNLLELNIKREHRLVELATSAIAGFAAFFERADTEPLGCDDTPIDWEALIDDAVAAAMALSTMGYMAQADEAWLLILRIGQMLDERFTYLRALTHFLGQDHLNSNQQLQLSEEVDRAQELLDDLWPQLQNGWFFKRQHTIVMLCLCHMASYYARQDCLCHAQLLLLQAEELRAQFDERVGKSDIVQITIQTVRFRLEYLRNKRCSSLPRRPTPLRQLDTLVDSVRNYCTVSSVDLGALQLLLADLVRESTECAANRLTERFAFYGTMLNLVLQSGMALRTIEVLISWLWMNLQMEYLDQAQSKLRLLDHLLAIKPLSRTLVEQTSATYVPAIAAKEDLKANAMSELTSNMLLMQLVEPIRKQNQMDVATIKSLPMHEPIPTSHQLQRYVSKQGTPPHLRDSMQLQCIYFIVGCLHARFSFLKRENDQLDDFYVGAGNWLQEDPVRTATLGSMLLVHELYHLNYLRFRKKHKEALSYAEAGLKSVYQTADINYSFNFMVQLKTARLELHPVGKARAKTIRRALAFNTSPEDKRRKGVVEGSIKAKSSARKTPRFKIYTELELRPPIGCSNSSSSSSKSGNENTPPSDHVDLNACQAIEISDDDAASVSASTPAPSQLKRSQSVPAKATKTRSARVGSQLKVPEIIELDDTMEETPSTSTAATVKRYPTTDARSSRARNRQLEETPATTRGRPRRKVPEPAPQQETVSLRPRQRN
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSLSRLGVRNVYGTSQQAEFYGNVDREDPEAILNGVAVSGLIGVLRQLGDLAESAAEIFQGIQEEVMATASRSNQLKMRLQHIEATVPPLEKAVLAQTTHLHFAYTGGVEWHPRIPHEQNHFIHDDLPNSFMDHYEECRDPPRLHMLDKFDINGPGSCLKRYSDPTYFRRASSSLVKGNNKFQNNNMSCKIKKKKSSSRSRDMSRLASMANQNARKTLTSFSFSGQTSSSKSASTSDMEKRSDLQDHHSHTYDCLSTATSSLKAGEKQKGGLGSSSLTPGSCTIGSVLSECETEDEHDNLQFTPLQGQSAVGSSCVSWDEKAEIVEEPLGVQTDEASVVDALDEKATSYGEGTGRVDIENAESEPGLQQSNGIDEVKEMKAGSEIVREPRDSSEHETESEGECFVDALNSIESESENEQGLKTSLEAVSSPCGVTGERLEKSSNKVEESCRSMDNGYLNATDEMNHQDPLESDNRSRSPLNDVCTTSNITCGEDKIGFTVVPAPENSLSDSSNPLYHSEHQKSEAKVSGEVEAIKIWTNGGLLGLNPSKPPVLEVPSLDCKAEERTFGSAEAEKDKSDDLVEHVLDTSSLGTQNLTVDQRECHETSSYGVFGGLSQKLFTNSFRRRDSLSHDNRQALPATIPENDEVTTEKSRFGEQDKVLFREEAPIDWFASSPPLQHMKISLNPVDNTLQASRLKLKFSDEDNNSNNTFPSFQLLPEAATSLPDSCSDDDTFCMTSDIDYLSDYHSLSDSEQWEEHNDSHERKEHDSFHESTHVDNNGEPSSLDTEAENGCVALNFSYLQSPVEPLPPPFPPAQWMVSKTGSETISENKTTQSIQLQDALRFAFEKHTSSSIVNKEEPNTVASAPKPETKVHVKNNVKEDKQNANEKETDADDFLQQIRTQHVNLKPVVMTRTLSTAAAATTDPAINIKISAMLEKANSIRQAVASNDGDESDTWSDT
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins.
Sequence:
MVVTKITQRKRKQPEWLVNDVHPVLDLTEDGDDSESLPMSVFESACNENGKDSPPKTVDFPSSDQEILSDNQEEDDLPSSNSAKDSPIVKDACMEVESPIETEPENHMEGNVSEVVLSIERIEPSTKINPLDIKISAHFIVVRGGDNKESIIYEWPLEKIARIGYCYHSDWEEDSKAYIVVTTSVPLVPLSGPSKAIDKCLLELSKFRESFHDILKLSPIFGGIIEELKLEDVTKTLRSIKSHNSQASTSFFTTYSEKSDESIDAFKVLVYPQGDPDAVTITRKDIKILNPFEFLNDTIIDFYIKYLQQTTIAPKKLENLHFFNSFFFSKLAEDGIGGPAAFERVKKWTRKVNIFEKDFIFIPVNQSLHWSLIIICHPGQMWDVTTADGSPVGDACILHLDSMEGFHRGLDRYIKSYLFQEWKERNPNEITNPYEVSYAEEFFSEMPYRYSKVPQQDNNCDCGLFLLHYVELFLKTAPPVYRTKRQKGFPTQFLQRNWFKPSEASAKRLVIKKLILELSLGRSLGSPRDNLELNENAPNGVFLADEDLTVALPMSLRADEQCTAQSISVPSPGRSDPSHQMKEAQIDDCAYPRLDDAQPCDDLSGAVSSSRQEESAELQHMDVSPDNLEGNNRCGGPEQSGNDGPRVSWKSGAAQLNSHVWVVDDDLESGPEAVIPPNDDTWIHENSSAPSLSLQVKPLQVPVLLDKLVLQYNRPSTTVDLRVQDDSQSSDDPSCSLLNEDAVKLQKNGALLEFDSVLSPDEGNNSGPANNDDEIHGSSVFDAKQRCATSNLQAEVASPVKGTLEVGSASGLSSEFVHALPDDYFKEEGLSLASGLSVTCRSTTSPSGRIFELNGQGALTFGLKKHSKDLDSPRKDHQSNGFTMNNGQVQVIEELTSDDSADDFEAWESVQRSIKDAKRPSLEGGRRVTRSTRMSQRLGLSAENQSRNNALEALLRNKESKRR
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MMEAQKWPEVSAESTLNGSAVRCMQEPPWESSNALNEDAKGIKEKENPLECPLCAKRFRQRQNLVKHQRIHTGERPYSCRQCGKSFIQKQHLTKHERLHTGERPFTCQVCGRGFSLKHNLKTHQRIHTGEKPYPCALCNKSFSRRENLHVHQKNHQGKCVPEVTAQLGTMPEATLLAYMYPQRQATIPTYIYSKDKATITACAYPVGPQIKPAPVYPLIKAACVYPEGPNIKAACVYPMEQKEQTGHVSTEGLEMKQPQVYPTGPEVKLACVDPSINIAGVCPEGPEIKPVFVYTGSQQTIPTEIRLMLESWKYEMPSETSESPQREEFGLSARPYICPQCGKRFSRIEIFVNHYKMHIGIKPYPCPECGRRFVQRHLLTKHLGVHSGDRPHSCSQCGKGFHLQIGLCKHQNVHHREKPFLCSQCGKKFASEPIYRSHWRIHSKCQASQDSVDSSGKSPPSVMERLSLPEGFHLNRLFIPHRLLPHVKGFKCNVCARMFQHKHTLISHLNIHSRERPFPCLKCGRKFTQKPHLTDHLRLHRGKKGYNCPRCGKMFNIEHNLTSHWSTHKPRRPYVCPDCGKAFHHDWSLVKHQRSHRTAKGKPCTSEIDRLISTSVTESEKIQVQQDTLQGPKQYSCPVCGLCFRRQVSLYQHELSHKGRTPIMCTPKQDNVQQSKKRDHVCNQLAQTFQGEQQLSSHHPTHPRGKPYPCDMCPRSFCLERSLVSHKKTHRTEKRPPNRRPHNTNPPAVLTNRNPTNEHPKTTGSGGAGVMPSVQICHVFPCSVCGKVFKWRQALVKHLRIHSGERPYPCHQCGKSFRQRQHLKKHLRLHTGEKPFTCQECGHSFSLKHNLHTHQRTHTGEKPYACIQCDKKFTRRSILLTHLKSHGLTVPETIPKEHSYNLYPQNVMPMGQVEIEVELDVP
The following text describes a protein:
Function:
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
Subcellular Localization:
Cytoplasm.
Sequence:
MKHLLTLMEFAPHEVEYLLRVSREFKTRFLAGEIYTPLFPGRVLILYFEKHSTRTRLSLTSAAAQLGIQAVYTTPNELQIARGETVADTMRVISRYAAAVAARVYKHETLEEMARHSAIPVINALSDKHHPLQALADALTLWERAGRLHNVKIAFVGDVSNNVATSLAIIGAKLGWEVRLVGPKQLWNQRLVDELAEDAAKTGARIYFTDSINEVAGVDGVYTDVWVSMGFEKEAEERRRLLKPYQVNQRVMEIAGKKAVFLHCLPAHRGEEVTDDVIDGPQSAVWDQAENRMHTAKAVLAYLLK
The following text describes a protein:
Function:
May function in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MEEEDESRGKTEESGEDRGDGPPDRDPTLSPSAFILRAIQQAVGSSLQGDLPNDKDGSRCHGLRWRRCRSPRSEPRSQESGGTDTATVLDMATDSFLAGLVSVLDPPDTWVPSRLDLRPGESEDMLELVAEVRIGDRDPIPLPVPSLLPRLRAWRTGKTVSPQSNSSRPTCARHLTLGTGDGGPAPPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQLPTLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKPPSSLGMTPAPVPTSLGLPPGPSSYLLPGSLPLGGCGSTPPTPTGLAATSDKREGSSSSEGRGDTDKYLKKLHTQERAVEEVKLAIKPYYQKKDITKEEYKDILRKAVHKICHSKSGEINPVKVSNLVRAYVQRYRYFRKHGRKPGDPPGPPRPPKEPGPPDKGGPGLPLPPL
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MHTLVSNRSEIKPQAMLEHELDHDSNNKDGDGAEALQYLFSIDPDAGDYCQPCSYPRHASPAAAPPHVPDSIPHNTLSSSCSYGIQALINNVHRGYINDDDDAPMMSPVPEDLSQQQESETLRQWKRKKELELQEKQRETQIKQDRILEHAAIERENFYKEREVQIEEKKRLNREKETKYRADAEMQQKLVEDNLWAAVAALIDLNGDQTDGMMTANGSGKQISKSQISTPKRVEQRRLKEYAVKPTKKTTDLSRMREILLKLQQRPLVRSSPHFAGKSPLEMERNMQ
The following text describes a protein:
Function:
FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Bacterial flagellum basal body.
Sequence:
MAQSFDYESASASEETETSPLERLAEIAARTAEESGKFANVDAILRIPVTMQVVLGSATIPVANLMKLGRGAVVPLDHRVGEPVDVVVNGRIVARGEVVVVEEDNSRFGVSLTEIVGPLGQGDT
The following text describes a protein:
Function:
Converts sphingomyelin to ceramide.
Sequence:
MLNKLIQVVLGTVGLQSALLGPPSLSNELQLGWVESQVESLLGASNDECSRCKNLLVLGNKLAKLNPALIPPILIRLCEKYNWKDDCEVYRDDTLARGAVGRHIANVLSLIDPRGVDGTNICWHFGNDACEFEMPQFEPHLSSWWGPRPEEPKSAGVKSEGTTFNVLHLSDIHIDLRYMEGAEADCNRYMCCVPESVNQNSPDKVVEPAQKLGTYHCDTPQILLEKSLAHVSSIASRVPFDFGVFTGDMISHDTDRFLSLSLTLQSEHECYYQMKKHLGDLPIYPTFGNHDSYPYAQMAQNSSGFAREFEWNTDLSSRMWRDYKWINEEQEEQARHTYGSFAVTTKSGLRVISLDSNFWYEENYYNYWNISNPDPSGIFRWLTNELLQAEETGTKVWLVAHVPTGGDADAVPWGTEVLRQIIVRFSPHVIAANLFGHTHADQFGVYYDSSNVSSPTEADAVSVAWIGQSITPIDKYNPAWRYYSVDSKTFEIMDSHNYYSPLNETYNVAEPKLEWKYLYSARKAYDPDREWPDDAPLNATFWHRAVKTFVDDKKQRQVFFDNFSRLSPYTRVCNTDECIKQMRCQMVGGTVDEIKLCLRRP
The following text describes a protein:
Function:
Protease that may play a role in T-cell development.
Subcellular Localization:
Cytoplasmic vesicle.
Sequence:
MTVWLARWLGPLLLVSLWGLSAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVGWLEQLLDPFNVSDRRSFLQRYWVNEQHWVGEDGPIFLHLGGEGSLGPGSVMRGHPAALAPAWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRHALADVVSARLALSRLFNISSSSPWICFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLECRAAVSAAFAEVERRLRLGGAAQAALRSELSACGTLGSAENQAELLGALQALVGGAVQYDGQAGAPLSVRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLGQKCLSFSRAETVAQLRSTEPQLSGVGDRQWLYQTCTEFGFYVTCGNPRCPFSQLPALPSQLDLCEKVFGLSALSVAQAVAQTNSYYGGQTPGANQVLFVNGDTDPWHVLSVTQALGSSESALLIRTGSHCLDMAPERPSDSPSLRLGRQNIFQQLQTWLKLAKESQVKGEV
The following text describes a protein:
Function:
Required for resistance to glycopeptides antibiotics. D-Ala--D-Ala ligase of altered specificity which catalyzes ester bond formation between D-Ala and various D-hydroxy acids; producing a peptidoglycan which does not terminate by D-alanine but by D-lactate, thus preventing vancomycin binding (By similarity).
Miscellaneous:
MISCELLANEOUS: S.coelicolor was found to be of intermediate resistance to vancomycin although it does not produce vancomycin.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MARLKVGIVFGGSSEEHAVSVKSAQEVARNLDTEKYQPFFVGITKDGAWRLCDGPGQDWENGDCRPVVLSPDRSVHGLLVLEQGQYRSVRLDVVLPVLHGTLGEDGATQGLLELSGIPYVGCDVQSSALCMDKSLAYVVARSAGIATPDFWTVTGDETIDPGRLTYPVFVKPARSGSSFGVSKVCRPEDLATAVESARRYDTKVLIEAAVVGSEVGCAILGNDPDLIVGEVDRIALSHGFFRIHQEEQPENGSENSTPVVPADIPTEKRSLVQETAKAVYRALGCRGLSRVDMFLKEDGEVVLNEVNTLPGMTSYSRYPRMMAAAGLPLSEVIDRTLSLALTGKLR
The following text describes a protein:
Function:
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini; Plays a role in nonsense-mediated mRNA decay.
Subcellular Localization:
Chromosome, telomere. Nucleus, nucleolus. Cytoplasm, cytosol.
Domain:
The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.
Sequence:
MANELDRVRISAAELRAEALNSSNITECVAVEHQNHQVQKQHKKREGKRPDLQRYQPAAGSGRSALDSEEGETPPNHLLPPDSSKLDQSIGNEKKGDAGKVSNRQGCTDCEPSTKKVEESTMKGDGSNNKNCREGSRSQPKGDAFNEEHQEVDKIAKTVKKARKPDREFYQPGTRRNIQGKDLNVGRDQEIPPTRKPEQNPEPQSQLSAKAREGNKDKNIQKQRGIDRAKSGQNVDITSKCSEVNREHQSRDVEKPVLPIDSSVKNITSSAEKMSIKEKDKTKGVGKASGESTYRGRQMTDKEKKGRPTETNDDAKKGEKGNHRTKEVEREKEKKWESRGENESSRRKNNSGRTEKDRNKKVLETDGKVSNKSSETKQSKGRDNRKQVRDRKDSSTSTDAGKQDKAQKDLDRSERHGSSAIAIAGASKRYSRSDIRHSRNRTYSSSSASSVTSQDGPGRGLNPEHNTDRMDYRDGRRSHLQSWTNSRHSSSESLERSDMSERAEERRKRRRRGGEGKKNAENHGEDRNTPKPNKGRGLITVKSYEEKKHLSGQSQSRETQNHKQGLVPRGRGGGILVLPARTDISNSPEIGQRLFSGGLRGGASYRSRGGRGGMRRLWDPNNPDQKPALSNTQPSLHSSLKHPVYLQSGPVHGQLHFLDTDDEVAGSPPIQGEHFQPRQAAAMAYYKFQSSDNPYCYPMATSNLHGPSTPTSHSFPYAYSMAPYQMPQSNGMYASHGAAQFSGSYRGAGYPQSGADSSLNIEETEQQTRGELGRMLRAADAHEVQLSNLLSRDRVSADGLDRMAQLRADLLGLYEQVILTDIEFSDSQNVDQALWKNVFYQVIERFRQLLKDPSYDNTPHIRNMLLTLLDEGAQFFDALLQKVQTVYQFTLEDYMDGMAIRARPLRKTVKYALISAQRCMICQGDIARYREQATDSANYGKARSWYLKAQQIAPKNGRPYNQLALLAIYTKRKLDAVYYYMRSLAASNPILTAKESLMSLFEEAKRKAEQLEQRRRQENEGGSQGPAVRGRRKDEESSRVEIWIRPNGQTATPFNKRGGSESSRDSEQDGELGSLSATDLKKRFILSFLHAHGKLFTKVGMESFPGVASRVIQEFKTLLQHGASLLGSTNILQIITINMFAVHNSQSKGEEGETRSVLQEQSTALGLGMFALLVQRCTELLKEIPAESIQVADGEEEEEKTGEPEGMVRVSAFPLDLRELLPGIKVWSDWMLGHPHQWNPPPCGIDCSPDVWQYLANLCNVLAHVDHEEVLLYKVDSDEGENDEELTVLQLKEDKLLAGFVPLLAAPQEPCYIDKHTDEAIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYISVATSASNNQSEDARNRQDSLTENEQADVILEAESSLSASEEEEEDFDGGGHSGNDIRQLKARHHALTNKLAQRQKRLDKIQAVLQPGGQLELEIRPLFLVPDTNGFIDHLEGLKKVLHCGSYIIVVPLIVITELDGLAKGQDTFGGGLGSRGRSTGSRGNYNSAAHVRAVQDKARLAVAFLEKGFEAREPCLRALTSRGNQLESIAFRSEDTSGQQGNNDDVILSCCLHYCKDKAKDFMPPQKNGTVRLQREVVLLTDDRNLRVKALTRNVPVRDIPSFLSWAKVG
The following text describes a protein:
Function:
Topoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes. It relaxes supercoiled DNA. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation.
Sequence:
MTQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILHADQSLEVIDDGRGMPVDIHPEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVNVRRDGQVYNIAFENGEKVQDLQVVGTCGKRNTGTSVHFWPDETFFDSPRFSVSRLTHVLKAKAVLCPGVEITFKDEINNTEQRWCYQDGLNDYLAEAVNGLPTLPEKPFIGNFAGDTEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNILPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFILWLNQNVQAAELLAEMAISSAQRRMRAAKKVVRKKLTSGPALPGKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSDDLSQLRYGKICILADADSDGLHIATLLCALFVKHFRALVKHGHVYVALPPLYRIDLGKEVYYALTEEEKEGVLEQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLTIDDEDDQRTDAMMDMLLAKKRSEDRRNWLQEKGDMAEIEV
The following text describes a protein:
Function:
Involved in resistance to abiotic stress.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MASYHVSHDSYQSPGPSPLYQPIIEAPPPPYPPTRTRYQDYYGGYGQPHPPPLRPYRSDHEYYGDGEYVGCFPFLRSCLTTLCCCWFVEQCCFRSRY
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MSSRRSIGGRRSSIHGSATGTSDPREWSDKQYLKKAIRDLVVFLSETGYPDMISAKMLAAPSNKIFVKMFQHIYGLLDPMFPWDKYKPEDEIPEIMKYLGYPFPIKKSTIFASGSSHNWPKLLGALTWLVDATRFLDMEDEIITLTRISENIFDPQDSDLFFSADIFDHGIQSYADFMSGHIDKPSCELLFAGRMEELVNTHAHLEEKHQGCIEELQKLEAECPALSAIETKRSALQEDRTRFLELIKTLKQHQERYQLKTAQTMQAITEKEQELEALNAEIAKLKVMRDQQEMTTADVERINAKQRQLERDLDLAEQRKDQLEQDLCKVEIDISKTVDGLQEQTAEANVLLQQFGMEAVVSVNGSVDQPHEQLNRQFPTCWIDDVHALFTFGARQQPGEISHPVALNSPSSCLLPVLQGQLHKLTSQTKDSDLHKLELKDRCQQLEEAVVTKRDDLSVMQTQLEALEQQCGELQEVISREYKKQQSHVTIMQSENQKRRMQLAGDLQDMLARKADLEAKQQQLQVAQAQERKAFANSVRRLIQMFTPFANEIHEQLETLEGGVDGVVAESKAILRTLQAFVEEQKA
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEKQKEVQLPSNSGRNAKWWYSTFHNVTAMVGAGVLGLPFAMAALGWGPGLAILVLSWIITLYTLWQMVEMHEMVPGKRLDTYNELGQHAFGEKLGLWIVMPQQLVVQVGSDIVYMVTGGASLQKFHNTVCPSCKPIKLSFFIMIFASAHFVLSHLPNLNSISGVSLVAAVMSMSYSTIAWAGSIHKGVLENVQYSSKATTTAGSVFNFFNALGSVAFAFAGHNVVLEIQATIPSTPEKPSKGPMWKGVIVAYIVVALCYFPVALIGYWIFGNGVKDNILVSLENPAWLIAMANFFVVLHVIGSYQVFAMPVFDLIENKWLVEKLNFKSSKMLRFIVRNVYVALTMFIAITFPFFGGLLGFFGGFAFAPTTYFLPCIMWLKLYKPKRFSLSWWINWICIVLGVCIMILAPIGALRSIILEAKTYQFYS
The following text describes a protein:
Function:
Plays a role in incorporating a subset of tegument proteins into the virion.
Subcellular Localization:
Virion. Virion tegument. Host cytoplasm. Note=Accumulates in a juxtanuclear location reminiscent of the viral cytoplasmic assembly compartment.
Sequence:
MMEAAAAAAAAFRPEERPTPGWHDAALLMDDGTVREHAFRNGPLSQLIRRVLPPPPDAEDDVVFASELCFYCSGRFNRRSSVFSIYWQKHSDLVYALTGITHCAKLVVECGQLGSSRLRWRDGDASGEERRGDDDSRDELYDVPGIYMIRVNDGGSTGPRHVIWPGTSVLWAPDVVITTVQRRISAARALVNTFRQYFFLLERRSHEELVLCPPEMEERLAPLLQSATRGDSDMFDGVVASAYHRLRMSNIPRSSARLLEHCVGLAGAKKLLLLDVPRLENYFLCQVCLYELDEDEMGEEMLGMLAGKPEDAAVSGASGGFLLHRKTMKLAACLCLLLNSLHLHQEALEALDPPPPRVEENDLVNVVLRRYYRSHGGVQARTLAAARALLADYAETFSPLGSFTRLGYDRLVSADAGVSRRHLVALLRA
The following text describes a protein:
Function:
Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR.
Subcellular Localization:
Cell membrane; Single-pass type III membrane protein. Nucleus. Note=Proteolytic processing gives rise to an intracellular domain that translocates to the nucleus.
Sequence:
MLYNVSKGVVYSDTALQGQDGDREGMWVGAGGALAPNTSSLFPPEPPGASSNIIPVYCALLATVILGLLAYVAFKCWRSHKQRQQLAKARTVELGDPDRDQRRGDSNVFVDSPPSLEPCIPSQGPHPDLGCQLYLHIPQQQQEEVQRLLMMGEPAKGWQELAGHLGYQAEAVETMACDQMPAYTLLRNWAAQEGNRATLRVLEDALAAIGREDVVQVLSSPAESSSVV
The following text describes a protein:
Function:
Thought to regulate endocytosis in coelomocytes through modulation of phospholipase C activity. Possible acetylcholine receptor.
Subcellular Localization:
Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Sequence:
MFPIFIVLVIHIHLVVSQWETGKSFTVLTKLRSDLFKNYNGSMPVGKGEYLEATPSLEVGFIHFIDDDHGFMSVVINAELTWIDERLKWNPANYSGVREIVEKTFEFRKDNNCWMPIVKYRSYDRRYSELDLLEFSDARTLISYKGEIKTALQTMVTTKCQFSFGEYPNDYQNCSIMLIPNQNADEFRFVSPNGYCNPKFENLEHRAVRVHDLHLMGVESNIFYTFANTYFTAEEVTGFEYMAKTEFRFNLMFKRVNKLLNVKLSIPSILISMFLIIAGLFPNGYSIFGYAYCFFVEVMHGLYVSKILPNDIRGIPYHGALALCFLIETVFLFCWKVFSVYARNQKLFAQLPNVFADNRVFVLKFVFYVDRVVCVALCLQFLSVIYKTR
The following text describes a protein:
Function:
Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity).
Subcellular Localization:
Nucleus. Note=Associates with chromatin during pre-replication complex (pre-RC) formation.
Sequence:
MNSILPCQDQYFVGGQSYNCPYSTTTSESGVDVSKETWVSFWAAGLLDNTELQQAPQVLESPSELSFPVLDSCSWEEAQLSSQLYRNKQLQDTLLQKEEELARLHEENNHLRQYLNSTLVKRLEEKAKKLLSSDEFSKVFGKLRKEKRKPKEHRHSPAEIPQFKTAKRNLSTEFSNCEEQPGPHVDPWVLQTLGLKDLNTIDDTLPANYSATTSHPRAVPSISSLFVHDANGYANVPRDLHLDYVGQGTHGSHTTSIHQEDCHSFPRLSNPPVRVQTLPYHTADVSPNKTEMAFSTSLSPHCNVKTHSFHQGQAFVRRDEEGGWKFTWVPKQT
The following text describes a protein:
Function:
Olfactory receptor that is activated by amino acids that act as potent odorants in fish. Displays preference for acidic amino acids such as Glu over basic amino acids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDLMSFILLWAGLMKVAEASIAQFSQLGASAPGNIIIGGLFPIHEAVVPVNYTGNNSISAPEHPDCIRFYTKGLNQALAMINAVEMANKSPMLSSLNITLGYRIYDTCSDVTTALRAVHDIMRPFSDCESPEDSSQPVQPIMAVIGTTSSEISIAVARDLNLQMIPQISYASTATILSDKSRFPAFMRTVPSDEYQTCAMAKLLKSNKWSWVGIIITDGDYGRSALEGFIQHTETEGICIAFKAILPDSLADQQKLNTDIENTLNIIENNPKVRVVISFAKSSQMQLLFKGLQSRNISNNMVWVASDNWSTAKHILNDGSITDIGKVLGFTFKSGNFTSFHQYLKNLQFESEDEMNNSFLKEFLKLNAGNASNTVLELMKSTNLDKIFSIEMAVTAVANAVAKLCAERQCQDSTALQPWELLRQLRSITFENGGEMYKFDANGDINLGYDLFLWEGDQSDEHADDIIAEYDPTKGGFHYIHNDLSEIKKVVSRCSNSCQPGQYKKTAEGQHTCCYECLTCVENHYSNITDADECSPCDSESMWSLANSTECHPKVFEYFDWNSGFAIVLLILAALGVLLLFFMSALFFWQRHSPVVKAAGGPLCHLILVSLLGSFISVVFFVGEPSDLTCRARQVIFGFSFTLCVSCILVKSLKILLAFEMNFELKELLCMLYKPYMIVSVGMGVQIIICTVWLTLYKPFKDKEVQTESILLECNEGFYVMFWLMLGYIALLALFCFTFAYIGRKLPQKYNEAKFITFSMVICLMAWIIFIPIHVTTSGKYVPAVEMVVILISNYGILSCHFLPKSYIILFKKEHNTKDAFMKNVYEYARKSAENIKGLTGTEPQFKQENSVYTISNLSFVPEEKHE
The following text describes a protein:
Function:
Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat (By similarity).
Subcellular Localization:
[Corazonin]: Secreted; [Corazonin precursor-related peptide]: Secreted.
Sequence:
MVNSQILILFILSLTITIVMCQTFTYSHGWTNGKRSTSLEELANRNAIQSDNVFANCELQKLRLLLQGNINNQLFQTPCELLNFPKRSFSENMINDHRQPAPTNNNY