lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs. The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.
Subcellular Localization:
Host nucleus.
Sequence:
MTAQPPLHHRHHPYTLFGTSCHLSWYGLLEASVPIVQCLFLDLGGGRAEPRLHTFVVRGDRLPPAEVRAVHRASYAALASAVTTDADERRRGLEQRSAVLARVLLEGSALIRVLARTFTPVQIQTDASGVEILEAAPALGVETAALSNALSLFHVAKLVVIGSYPEVHEPRVVTHTAERVSEEYGTHAHKKLRRGYYAYDLAMSFRVGTHKYVLERDDEAVLARLFEVREVCFLRTCLRLVTPVGFVAVAVTDEQCCLLLQSAWTHLYDVLFRGFAGQPPLRDYLGPDLFETGAARSFFFPGFPPVPVYAVHGLHTLMRETALDAAAEVLSWCGLPDIVGSAGKLEVEPCALSLGVPEDEWQVFGTEAGGGAVRLNATAFRERPAGGDRRWLLPPLPRDDGDGENNVVEVSSSTGGAHPPSDDATFTVHVRDATLHRVLIVDLVERVLAKCVRARDFNPYVRYSHRLHTYAVCEKFIENLRFRSRRAFWQIQSLLGYISEHVTSACASAGLLWVLSRGHREFYVYDGYSGHGPVSAEVCVRTVVDCYWRKLFGGDDPGPTCRVQESAPGVLLVWGDERLVGPFNFFYGNGGAGGSPLHGVVGGFAAGHCGGACCAGCVVTHRHSSGGGGSGVGDADHASGGGLDAAAGSGHNGGSDRVSPSTPPAALGGCCCAAGGDWLSAVGHVLGRLPALLRERVSVSELEAVYREILFRFVARRNDVDFWLLRFQPGENEVRPHAGVIDCAPFHGVWAEQGQIIVQSRDTALAADIGYGVYVDKAFAMLTACVEVWARELLSSSTASTTACSSSSVLSSALPSVTSSSSGTATVSPPSCSSSSATWLEERDEWVRSLAVDAQHAAKRVASEGLRFFRLNA
The following text describes a protein:
Function:
May act as a component of the auxin efflux carrier.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIGADDFYNVMCAMVPLYFAMFLAYGSVKWWKVFTPTQCSGINRFVAVFAVPVLSFHFISQNDPFQMDVRFLLADTLSKVFVLVALALPAVIFRCRLDWVITLFSVATLPNTLVMGIPLLEAMYGGFTRSLMVQLVVLQCIIWFVRLLVYPPSSLPAKVLIWLDIYLSMHNARRYTLLLFLFEYRAATILIRSNFPGEMAAAITDIEVDGDIISLDGRNQPLLTETDTDHNGNVHVHIRRSTSTVLESTSHSVDTSRHSNLSGAEIYSVNTRASSDAYSLQPTPRESNFEELDAADTPVWIKSPASTNSAGLKVFRPQYSPSNVVVVWEHGNRDHVVGDGNKAIESGEGKDISFRSTTKFMEDEADEEAGDSSKAQKMPGTGVMARLILTMVVRKLMRNPNTYSSVIGLVWSLVSCRWGLEMPILMKNSIKIISNAGLGMAMFSLGLFMALQPQIIACGAKLATISMVIRFVCGPTVMSVASIAVGMRGVKLHAAIVQAALPQGIVPFVFAREYGLHPDILSTGVIFGMLVSLPVTLLYYIFLGM
The following text describes a protein:
Function:
Adenine glycosylase active on G-A mispairs.
Sequence:
MSLARSWGGRIEMATTWSVYSRRTRSSSIKPPGFSDSTAQSGGRTDEIPSVKAITRARSRRSSELKLSVENNDSRNATTTSILKAAQRTNPVKARKRGGVSGQDSVVDIEEVPASQSSYSFCKEDAASIRSCLLSWYDEHHRTLPWRQNLHSRHRQDVIDCRHDELRRPKDEVEEEDKEKGPGGQAGVDPKDLKGGQAVGKKETRNKSRRAISDEGPKSDRQDLSKILVTDDQRAYEVWVSEMMLQQTRVATVIEYYNRWMKKWPTVHHLAQATQEEVNTLWAGLGYYRRARFLLEGAKQIVKESNGFPRSLEELRDVPGIGSYTASAISSIAFQKPVPLVDGNVTRVLSRLRAIPDSPKLRTTVKLLWALAEELVDAKRPGDLNQSIMELGATVCTPTSPSCSSCPVSKYCRALSSSSKLVTDFPVKVAKVPRREEHVAVCVLEVLNNVTEDDNDEATVSKPDSYILLVQRPNQGLLAGLWEFPSVSLGAVPACGKELTAAMDRYLKESLDYDLVKKGSFSVQKRETVGTYIHLFSHIKMHMSVEWLLLCPSESSEWQRNFMNIREASVHYKWVQADTVGKLGLTTSVKKIHSMYVNHLKLRSQAEAPKPKRRKGRSGNGQ
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MSQPSFNPLVSPQSHTPISRPGGHGNNTHAPGVVGEGSLAGVSAPVYMAHPAYEGQAVEEHHPVQPPVPTAAVPHMEHYPGYPHVDMGRVPYHTPYDPYYSATMMGYGHQPMAPHPLLAAQTARMPLPMSELLPEEEPVYVNAKQYHGILRRRQIRAKLEQENRLVKARKQPYLHESRHQHALRRARGCGGRFLNTKPEKKDEEQGGAAQEGANSSGATTEAPQNQETGAASQQNPNNLPEAPSNLQHEEQPALVYSNAVVVPQYMHANGQAGYPMAAYHPHYGPGSEQLPQPGLTSQ
The following text describes a protein:
Function:
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the antibiotic 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA) and its derivatives. The direct non-reducing polyketide synthase dbaI product is 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA), produced by condensation of one acetyl-CoA starter unit with 4 malonyl-CoA units and one methylation step. The FAD-dependent monooxygenase dbaH is responsible for the synthesis of yellow pigments derived from the oxidation of DHMBA. The roles of dbaB, C, E and F have still to be determined (Probable).
Sequence:
MTRTSPTLPVIILGAGMVGLTLAQALKKAGIPYEVYERDSAADTEKGRGWALTVHWALNALEECLPAELFNRLEEIQVDPTLDDSRRFCFLDLSTAIPKYVIPPSKRLRVNRRLLGNLLGEGLDINYNKTLSSFHVSPETPDSVTVTFTDGTSTTGCLLVGTDGRNSKTRRLLLGEEAGALNPLPVRSIGTTITMTPEQFAPIREIDPLLFQGSHPETGVYMWFSLVSSPTINGSKDTPNPFYEGQLIQSWLYKSEKDAVPETDADRLALFKNNAQHFQRRLREAIETLPEDSKVLHIKLVDWVPVDWDNRGGRVTLAGDAAHAMTSYRGEAFNHGVADAAMLSRNIIAAWTNPGMTGGIADAPDSPIVSKRAKIAREARDARARAKLSEIAV
The following text describes a protein:
Function:
Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.
Subcellular Localization:
Nucleus.
Domain:
The atypical PHD domain functions as a negative modulator of cofactor binding.
Sequence:
MQSFREQSSYHGNQQSYPQEVHSSSRIEEFSPRQAQMFQNFGGAGGGSSGTGSSSSGRRGTAAAAAAMASETSGHQGYQGFRKEAGDFYYMAGNKDTVAAGTPQPPQRRPSGPVQSYGPPQGSSFGNQYASEGHVSQFQAQHSALGGVSHYQQDYTGPFSPGSAQYQQQASSQQQQQQQQQQQQQQQQQQQQVQQLRQQLYQSHQPLPQTTGQPASGSSHLQPMQRPSTLPSSAGYQLRVGQFGQHYQSSASSSSSSSFPSPQRFSQSGQSYDGSYSVNAGSQYEGHNVGSNAQAYGTQSNYSYQPQSMKNFEQAKIPPGNQQGQQQQQQQPQPQQQQPQQQQQQQQQQQHPPQHVMQYTNAATKMPLQSQVGQYNQPEVPVRSPMQFHQNFSPISNPSPAASVVQSPSCSSTPSPLMQSGENLQCGQGNVPMSSRNRILQLMPQLSPTPSMMPSPNSHAAGFKGFGLEGVPEKRLTDPGLSSLSALSSQVANLPNTVQHMLLSDALTPQKKTSKRPSSSSKKADSCTNSEGSSQPEEQLKSPMAESLDGGCSSSSEDQGERVRQLSGQSTSSDTTYKCGASEKAGSSPTQGAQNEAPRLSTSPATRDEAASPGAKDTSLSSEGNTKVNEKTVGVIVSREAMTGRVEKSGGQDKGSQEDDPAASQRPPSNSGVKEISHTSLPQPDPPGGGSKGNKNGDNNSSNHNGEGNGPSSHSAVGPSFTGRTEPSKSPGSLRYSYKESFGSAVPRNVSGYPQYPSGQEKGDFGSHGERKGRNEKFPSLLQEVLQGYHHHPDRRYPRSAQEHQGMASGLEGTARPNILVSQTNELASRGLLNKSIGSLLENPHWGPWERKSSSTAPEMKQINLSDYPIPRKFEIEPPSSAHEPGGSLSERRSVICDISPLRQIVRDPGAHSLGHMGTDARIGRNERLNPSLSQSVILPGGLVSMETKLKSQSGQIKEEDFEQSKSQASFNKKSGDHCHPTSIKHETYRGNASPGAAAHDSISDYGPQDSRSTPMRRVPGRVGSRETMRGRSSSQYHDFAEKLKMSPGRSRGPGGDPHHMNPHMTFSERANRSSLHAPFSPNSESLASAYHTNTRAHAYGDPNTGLNSQLHYKRQMYQQQQEEYKDWASSSAQGVIAAAQHRQEGPRKSPRQQQFLDRVRSPLKNDKDGMMYGPPVGTYHDPSTQEAGRCLMSSDGLPAKSMELKHSSQKLQESCWDLSRQTSPAKSSGPPGMSNQKRYGPPHEPDGHGLAESAQSSKPSNVMLRLPGQEDHSSQNPLIMRRRVRSFISPIPSKRQSQDVKNSNADDKGRLLHPSKEGADKAYNSYSHLSHSQDIKSIPKRDSSKDLPNPDNRNCPAVTLTSPAKTKILPPRKGRGLKLEAIVQKITSPNIRRSASANSAEAGGDTVTLDDILSLKSGPPEGGTVATQEAEMEKRKCEVVSDLVSVTNQESNVEKPLPGPSEEWRGSGDDKVKTEAHVETASTGKEPSGTMTSTASQKPGGNQGRPDGSLGGAAPLIFPDSKNVAPVGILAPEANPKAEEKENDTVMISPKQESFPPKGYFPSGKKKGRPIGSVNKQKKQQQQPPPPPQPPQMPEGSADGEPKPKKQRQRRERRKPGAQPRKRKTKQAVPIVEPQEPEIKLKYATQPLDKTDAKNKSFFPYIHVVNKCELGAVCTIINAEEEEQTKLVRSRKGQRSLTPPPSSTESKVLPASSFMLQGPVVTESSVMGHLVCCLCGKWASYRNMGDLFGPFYPQDYAATLPKNPPPKRSSEMQSKVKVRHKSASNGSKTDTEEEEEQQQQKEQRSLAAHPRFKRRHRSEDCGGGPRSLSRGLPCKKAATEGSSEKTVSDTKPSVPTTSEGGPELELQIPELPLDSNEFWVHEGCILWANGIYLVCGRLYGLQEALEIAREMKCSHCQEAGATLGCYNKGCSFRYHYPCAIDADCLLHEENFSVRCPKHKPPLPCPLPPLQNKTAKGSLSTEQSERG
The following text describes a protein:
Function:
Possesses dual functions in bile acid metabolism (By similarity). Acts as a bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids). Can hydrolyze the amide bond in all six major human conjugated bile salts, namely glycocholate (GCA), glycodeoxycholate (GDCA), glycochenodeoxycholate (GCDCA), taurocholate (TCA), taurodeoxycholate (TDCA) and taurochenodeoxycholate (TCDCA). Shows a slight preference for glycine-conjugated bile acids as substrates. Also acts as an amine N-acyltransferase that conjugates a wide variety of amino acids to conjugated and non-conjugated bile acids, thus producing bacterial bile acid amidates (BBAAs) - also named microbially conjugated bile acids (MCBAs) - in the gastrointestinal tract. These BBAAs may facilitate communication between the microbiota and host through the activation of human ligand-activated transcription factors (By similarity). Is totally inactive toward penicillin V.
Sequence:
MCTGVRFSDDEGNTYFGRNLDWSFSYGETILVTPRGYHYDTVFGAGGKAKPNAVIGVGVVMADRPMYFDCANEHGLAIAGLNFPGYASFVHEPVEGTENVATFEFPLWVARNFDSVDEVEETLRNVTLVSQIVPGQQESLLHWFIGDGKRSIVVEQMADGMHVHHDDVDVLTNQPTFDFHMENLRNYMCVSNEMAEPTSWGKASLTAWGAGVGMHGIPGDVSSPSRFVRVAYTNAHYPQQNDEAANVSRLFHTLGSVQMVDGMAKMGDGQFERTLFTSGYSSKTNTYYMNTYDDPAIRSYAMADYDMDSSELISVAR
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MDGKPQVEVIVNGQVVPNLDDREYRLIKLENDLEVLLVRDPETDNASAAIDVHIGSQSNPRELLGLAHFCEHLLFMGTKKYPDENEYRKYLESHNGISNAYTASNNTNYYFEVSHDALYGALDRFAQFFIDPLFLEECKDREIRAVDSEHCKNLQSDSWRFWRLYSVLSNPKSVFSKFNTGNIETLGDVPKELGLDVRQELLKFYDKYYSANIMKLVIIGREPLDVLQDWAAELFSPIKNKAVPIPKFPDPPYTDNEVRKICYVKPVKNLRRLDIVFPIPGQYHKYKCRPAEYVCHLLGHEGEGSYLAYLKSLGLATSLIAFNVSITEDADIIVVSTFLTEEGLTDYQRVIKILFEYIRLLDQTNAHKFLFEETRIMSEAQFKTRQKTPAYQYAHVVASKLQREYPRDKVLYYSSVLTEFDPKGIQEVVESLRPNNFFAILAAHSIEKGLDNKEKFYGIDYGLEDLDSQFIDSLLHIKTSSELYLPLANEFIPWSLEVEKQPVTTKLKVPNLVRNDKFVRLWHKKDDTFWVPKANVFINFISPIARRSPKVSVSTTLYTRLIEDALGEYSYPASLAGLSFSLSPSTRGIILCISGFTDKLHVLLEKVVAMMRDLKVHPQRFEILKNRLEQELKDYDALEAYHRSNHVLTWLSEPHSWSNAELREAIKDVQVGDMSDFISDLLKQNFLESLVHGNYTEEDAKNLIESAQKLIDPKPVFASQLSRKRAIIVPEGGNYIYKTVVPNKEEKNSAIMYNLQISQLDDERSGALTRLARQIMKEPTFSILRTKEQLGYIVFTLVRQVTPFINLNIFVQSERSSTYLESRIRALLDQFKSEFLEMSDEDFSKHKSSLINFMLEKHTNLKEESSMYWLRICDGFYDFTRLEKQAEIVSTITKDEFYSFFINNIHYEGENTKKISVHVVSQRCEDEVYEIPNVTIIENGNMFKESMTLSKAAFPLKPFDEIDRSLLFN
The following text describes a protein:
Function:
Has acyl-CoA thioesterase activity.
Sequence:
MHVSKKEIEVRYAETDQMGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDINISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKPIQFRKAFPDWHTAYEKAKK
The following text describes a protein:
Function:
Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSHDTNTIDSRTHEGELNKLGFWIFITAEFALFGTLFATLLTLQHGGDYAGKMTTELFELPLVLIMTFALLFSSYTCGIAIYYMRQEKQKLMMFWMIITLLLGLVFVGFEIYEFAHYASEGVNPTIGSYWSSFFILLGTHGCHVSLGIVWAICLLIQIQRRGLDKYNAPKLFIVSLYWHFLDVVWVFIFTAVYMIGMVYSG
The following text describes a protein:
Function:
Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (top1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped top1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The SUMO interaction motif (SIM) is important for binding to pmt3/smt3 (SUMO).
Sequence:
MLRINDDDHPNEKIGFISAIKGDFHDLSSDYLKRIAAMAFPIMKEHGFGVTSLDEVAYNAKFWGRNWNKGECIELVLRDASNRWLPFEFVMDVFLHELCHIWQGPHDRRFFSHLSTLRAALIALYAKGYKGPGKYMTWDSFVLANVVGNYNTVVFNGITLERSTMHGVETCGGSLQRKKKIRRKPTPSSTKKRKLTRTGQKLGTDMNIRLELLKSPAKPQAQSMRGREARIAAALLRVDNSNEYKPKDHNSSTTLENYFVVE
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MLLFIFIALASSLRIQKNFFISNIERTVQLTDRYVYIKSKINFKNDGVIPIEKIYYTIHSALSDKLYHVNIEESNAKRVIEDVDVKYKQNATVYEFTLQKSIEPSTDQEVELNEYYYKRFKPMPKEIGVEDEQLVQFMDSVYFFTPYFVQNQITYYETPKIISYTLKSATQRNSLLEFGPYQDIKAFSTQIHTIHLENNTPMTVFTKASKIIEVSHWGNILIEENYSIENQGAKLKGEFGRVNFNKYNPNVGKHSLKQLSASLPYDSWGVYYRDEIGNISTSNAAKGKLNGENQALIQLRPRFAIFGGWRSNFTLGYNLPTKKYLEQDGNNFKLTLNFPFSVKEMVSDSYNFQISLPEGAYDIRVDLPLQVERNDTLLFSYFDTVGRPTIILDKTTTSQFDNKQIIITYKFSGISILREPLMIFGTFLFAFLLIIYLRRLDLQTLKLKE
The following text describes a protein:
Function:
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Sequence:
MAQERPSPALEPEHVQQLLFSCREAKKSAYCPYSRFPVGAALLTGDGRIFSGCNIENACYPLGVCAERTAIQKAISEGYKEFRAIAIASDLQDDFISPCGACRQVMREFGTNWAVYMTKPDGTYVVRTIQELLPASFGPEDLQKIQ
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MSNLCDARRRNGNGKAPERSSFVQTCNLLSQFIKGKATIRDLNLGIAGQPEAAGKTETATMDLLTVMEKPSIDLTKEEHKSVDLVTTESSREKEAAVNEPSTSKEAPKEPKAAQLTMFYDGKVIVFDDFPADKARAVMLLASKGCPQSSFGTFQAINIDKINTCSPAPASLTSNRTDSVAPQQQHLQIKPDSCSAAPQQHKHNSPPLHVCSSTKTDQLKLGSVSSAPLVEQEQHKQIQSQAAEISSSSELPIARRSSLHRFLEKRKDRATVRAPYQVVRNNPLLPSSSNTNGESSSKDSEDQLDLNFKL
The following text describes a protein:
Function:
Possesses 5'->3' exoribonuclease activity (By similarity). Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II (By similarity). Essential for vegetative cell growth and chromosome segregation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGVPALFRWLSNKYPKIISPVIEELPYEVNGEEIPVDITKPNPNGEEMDNLYLDMNGIVHPCTHPEGKPPPANEQEMMVEIFKYTDRVVNMVRPRKLLMIAVDGVAPRAKMNQQRARRFRSAQEAKEADEKKEEFRKMLAKQNGNKVDEELQEEVVKKTWDSNVITPGTPFMDILAASLRYWIAYKLNTDPAWEKLKIIISDATVPGEGEHKIMEFIRSQRAAPEHDPNTRHVIYGLDADLIMLGLATHEPHFRVLREDVFFQESRARTCHLCGQQGHKAEECRGQAKEKNGEFDEKQKGSSLKPFIWLHVSILREYLAAELYVPHQPFPFDLERALDDWVFMCFFVGNDFLPHLPSLDIRENGIDTLIAIWRDNIPVMGGYLTEDGHVDLKRAQLILQGLAKQEDAIFRRRRQAEERKLANEKRRKQEAKAREEERARKRRRSSPTYEPMDSPVGHRAPRGGGDAAPPNQLELITPSRGELSRQTRELTHSMVVNRGAVYRANMANKSAAAVLKSKLMQGSQNGQNGEEKSEGATTNNDEPSQDQPDQTEQTSPSVLGKRKADLVEEEDTDAGTPGRDSPAVPVAAKEDELPPDTVRLWEEGYADRYYEQKFGVDPQDKEFRHKVARAYAEGLAWVLLYYFQGCPSWTWYYPYHYAPFAADFVDIGDMEITFDKGVPFKPFEQLMGVLPASSNHAIPKVFHDLMSSPDSEIIDFYPEDFAVDLNGKKFAWQGVILLPFIDEKRLLAAMEKKYPLLTEDEKLRNSVGREVLLISEAHPLYQDLVANFYSKKQGVQKYKLNMRISDGLAGKVERNEAYIPHSSLPSSLEEYGMPSLEDDRSLTVNYEIPKSNHVHKSMLLRGVKFNPPALDNADIQAVKHKAQNSGRSYGGAPLRGGQKGGRINYASDRPNPFAAHLDPGFIPPVPGNVGGGPIMPSGWVPPIPGSAGFSRGPPPPPHGGMSGSHHRPPYGQGPGQYQGNHGQGDHYGQGQQGYYNQSSYYNQSNQYNGRSSDHGGSGGYRGGGGYHRGGNYRGGGYRDQRQYNQDQYSSRNSGGYGRY
The following text describes a protein:
Function:
Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.
Subcellular Localization:
Peroxisome.
Sequence:
MRPKLTLQQLNVLSPGEFHKTFENVIECWPEAAIFCSALLPFKSFATMIAAFQSYLERLPAETKLKILRLYPDLAGKMLDTNQLSEDSTNEHASVGLDNLSPEDKKKLTDLNESYKAKFGFPFVVCVREASKFEVILRSVSERIHHTVEQELEIALEEVKKICRLRILQLVDNL
The following text describes a protein:
Function:
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
Miscellaneous:
MISCELLANEOUS: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEQIVTPESSTPVVPNKETKINLLDLNRQQMREFFKNLGEKPFRADQVMKWMYHYCCDNFDEMTDINKVLRGKLKEVAEIRAPEVVEEQRSSDGTIKWAIAVGDQRVETVYIPEDDRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIVGAAKVTGQRPITNVVMMGMGEPLLNLTNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPNDTIRDEIVPINKKYNIETFLGAVRRYLEKSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKETPCKINLIPWNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQLAGDVIDRTKRTLRKRMQGEVIDIKAI
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTNYGAIPTSSHASTSPVVDVESLSSDNQRTKPARAMPRRPLGVMLDVHAIGLPRSVSDASSRIKTNSNYFRMNYSIFLSIIYLIVIYSGLIKHPVSLIAFTVLVSIYIFFFNLQYHEPVELFHYHINSWTFLIVKICLMLLAVLLLLWTKETYSFRWPLLIGCIVILIHTVVRKTEDLFLDEEAVATTETYWNRGLILALFLQICLG
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MTTQHSHSQFTQNHEMSQESNEFNKLLRTIQNEIQSPVLEIFDNVRVSQFKQMIFNQQQIIANLKNQTDVSSITLMQCQTFQIEISRIQYYLTLYSKTRLRKIHQMARCNSNDTSKMTSDENTLFEKYKLLRNEFLQKSQIFEPKAEAKPDMSTFVFVRILTNVDNFKIHPDDEYGFEMQKGEVYLFPYYSVHDFINTNTFELI
The following text describes a protein:
Function:
Controls the expression of a small regulon that may play a role in the utilization of cholesterol.
Sequence:
MAPDTPSQPASRRDELLQLAATMFADRGLKATTVRDIADSAGILSGSLYHHFKSKEQMVEEVLRDFLDWLFGRYQQILDTATSPLEKLTGLFMASFEAIEHRHAQVVIYQDEAKRLSDLPQFDFVETRNKEQRKMWVDILQEGVADGSFRPDLDVDLVYRFIRDTTWVSVRWYKPGGPLSAEQVGQQYLAIVLGGITQSQGDKHA
The following text describes a protein:
Function:
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein.
Sequence:
MTTSLQDGQSARGKAAARGLGLAQVCGAAQGRGDASALAVRPQGLPCSTREGAHFCSADRRKKKDLNVLEMPSIPNPFPELCCSPFASVFSASLFPKANSRKKQGNNCSSEDCFSYIPEILVIKVYNEDGTSRALEVPSDTTARDVCQLLILKNHYINDNSWTLIEHLPHIGLERTIEDHELVMEVQSNWGMEEENKLYFRKNYAKYEFFKNPMNFFPEQMVSFATETNGELSQAPILQNFLSSSTYPEIHGFLHAKEQGKKSWKKIYFLLRRSGLYYSTKGTSKEPRHLQFFSEFGSSDIYVSLAGKKTHGAPANYGFCLKPNKAGGSRDLKLLYADEEQSRTCWVTAIRLLKYGMQLYQNYMHPCPGRSSCSSQNMSPIRSISENSLVAMDFSGHKSRVIENPTEALSVAVEEGLAWRKKGCLRLNTHGSPTAPQNSSTNLALHKAQPWFHHRISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSLSHGRKIKHFQIIPLEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCSRIAL
The following text describes a protein:
Function:
Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
Sequence:
MVILAIGGYDPTSGAGISADIKTAHTLGVYCPTITTSVIPQNNKMVYEKFDLPEENIKNQFKAVFEEFDIEYVKTGVLTKPAIDTLLKYIDKYDLKVICDPVLASTTKFSFVDEKLMEKYIELFNKSFLITPNKEEYKKIMEFIKNNNLMIRNDLYILATGIDDILMKNFKPIKTFKGFRVDKEVHGTGCVYSTAITAFLSKGYDLEEAIKEAKRFVLSSVIYAKKSKFGYNSNPTYINKEKVIKNLSYAIYLLKKMNFTLIPEVGSNIAESLPFPKDFKDVAALTGRIIKNKLGGFYIVGDIEFGASEHIAKIILSASKFNPEIRACMNIKYDGGLIKLLKDKFAVSSFDRKEEPPNVSTMEWGTKIACEKFGGVPDIIYDRGGEGKEPMIRVLGRDAIEVVKKVEVIQKIYNTLM
The following text describes a protein:
Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Sequence:
MLSWDEFDKEDPTEAKAAPAAAQAVAQGHDKLDDEAAGSVEEARAVSADDSDAVARAKKALNDLDIQEGLDDLEGSAARVQVGDKQMINARADLNQLVPFKYDWAWQKYLDGCANHWMPQEVNMNADIALWKSKDGLSEDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNPECRQYILRQAFEEAIHTHAYQYCIESLGMDEGEIFNMYHEIPSVAKKASWGLKYTRSISDPMFQTGTPETDRQFLRNLIAYYCVLEGIFFYCGFTQILSMGRRNKMTGTAEQFQYILRDESMHLNFGIDVINQIKIENPHLWDAQMKDEATQMILQGTQLEIEYARDTMPRGVLGMNAAMMEDYLKFIANRRLTQIGLKEEYPGTTNPFPWMSEIMDLKKEKNFFETRVIEYQTGGALSWD
The following text describes a protein:
Function:
Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway (By similarity).
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MNAFVTVGSTQFDDLIRAVLKPEFQHCLVKHGINQLIVQYGKGKQAFGDPKSVAGLTILGFDYAPEIESYIHDASIVISHAGAGSILQTLRSGKRLLVVPNESLMDNHQVELATKLASMNYLVTCSTSNLVEGLEELYPKILTPFPKSDCSTFQKVMQDVAR
The following text describes a protein:
Function:
Unwinds and/or cleaves 5'-tailed RNA in vitro (By similarity). Has ATPase and GTPase activities (By similarity). Unlike the protein in mycobacteria there does not seem to be an antitoxin gene upstream, suggesting this is not a toxin-antitoxin system (Probable).
Sequence:
MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYMDEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDNRILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYSGYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGTVLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQTEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELDAILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGDPEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL
The following text describes a protein:
Function:
Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MQPIISFEQFTFQYGHAAQPTLSDITFHIYPGEKVLIAGRSGSGKSTLAHCINGLIPFSYEGNSTGNVLIAGKDPREGSIFEQSKQVGTILQDQDAQFIGLTVEEDVAFYLENECVKQDNMKKIVSDSLRKVKMHTFHKQSPHELSGGQKQTVSLAGLLTTNADILLFDEPLANLDPLSAIHTIELMKDIHEQYNKTIVIIEHRIEEIFKLDLDKVILIDEGKVIAMGTPKEILASNILPRIGLREPIYIEALKRLHFDSNNDVIYPMENLQKEKVSNVIKEWMEKQVILKRNAKNKELLKVENLSFSYPNKQKVLENVNLLIYEGEIVALLGHNGAGKSTLAHSLIGINKMKNGKIALKGEDISSWSIRKRGEIISYVMQNPNHMITQPTVFEEVSFTLTLHNFSKEEIKNKVEGILKICGLYPFRNWPIQALSYGQKKRLTIASVLTTNPKLIILDEPTAGQDYYHYKQFMSFIKNLAKKGISFVVITHDMNLALEYTDRAVVLHEGKIIADNTVFDVLGNQETLQRANLRESSLTKLIKFSGIACPEKFMELYLDSTRREEGA
The following text describes a protein:
Function:
Subunit of the protein translocation channel SecYEG.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYYALLTLFVIIAVVLIISTLLQKGRGDVGAAFGGGMGQSIFGVGGVETILTKATYWLGALFLVLALLLSVIPKEKGSVVEKSVQTEQSEGKGTTQESGK
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MLGPVYTESLRYRTAYYPPHPCGPVPAPHPAFLPHPPQPHPPQPHPPPPPQHTAMYSSHSYPYAFNQSPHQTPPRHTPPQAHMPMPNPPQSQPNLSYPHPTSSSYPASSSYPTPPTSSPQAPMAAAVGAPGASRGSSEFPLLAHLSVDELQRLLSCEDKLNDIAADDANQNKQRRVDKEMAMAENRSLADHNLSRETRLREGRNQLGRLHEEAKSIRDVYDVDRRRLESLNENFSLDAAKVMLETSATKTEEESEEIAEEFLNGNLPISDFVEQFMQRRMMAHVRRIKSDKMQELLRKPSYPALPQNVDIPMTTPMGYTPMPARPAPGVPPATGNQMPSYYPGHPAHIPAPAPAPVAYSGSPWAAYQSTPNMPSLPAFPR
The following text describes a protein:
Function:
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.
Subcellular Localization:
Cytoplasm. Cytoplasm, P-body.
Sequence:
MKPGGKNEKGGYHAVPPPPSLYGQYPFQCQQQSPVSKPRTRSAGGTEDLAARERDRDRDGEKKFRKRPSRKSKQFVSPDNGSGVEIFKSCDERASPTSSPVSPNFSVQRSRDYHVVKTLYKNGKYSELEFKEFTETLPPYGPALNNNHDQPSSSNSVAFVSPGKGASPLSTRFYGDTDTNFQLMKDPVAPQIFPEHWSLPKVNEAMQSGRVFSCSLRVNAHNRSEAYATVDGLSVDILIEGACAQNRALEGDLVALVLDPPNLWPRMKGLNNNRTDRVVTASSIAVTNQSFSSGEGVQVSREIRLEEEVVIESVGRSNQVVESSEDSSSLLTGTGSTALEKVQALLQATPGKRPTGKVVSILSKSRRRDAVVGFLSVKFQPPTRNQMVLTPVDAKFPKMVVLPDSLPEVIAQRLRDGDRKMGNELLAACVDRWDCNSPYPLAIITHCLGQAGELEAQTAAILFEHAVHSAEFPPEAMACLPRVPWSIPEKELQRRRDLRSRRVFTIDPVTARDLDDALSVEHLGDGLTRVGVHIADVSYFVHAGSGLDKEAQQRSTSVYLIQQVLPMLPRLLCEELCSLQPGVDRLAFSVMWDLDSTGQIVKQWIGRTAIKSCCKLSYGDAQEIVDGTFSEKPGLSGNFSWQEVAADIKTLYNIAKQLEESRIRDGALRLDTGKLVFALDGDGNPHETSFYEQMESNKLVQEFMLLANVSVAKVISRAFPDCALLRRHPEPSSRKLLEFQEFCKKHGFVLKTDSSADLHASLEVLREELKDDPVLLSIVTLYATKPMQVAKYFCTGRDKDGDWGHYALAMPVYTHFTSPIRRYPDIVVHRTLSAALEAEKLLNKSLTGPEDLVSTKDYEVLQLAASKHRISDPAEMALVADHCNERKMASKNVQEATDRLYLWTMLQRRKGLLSDACVVGLGPKFMSLYVSKIAMERRLYYDEVEGLKVDWLENTGTLVLDYCRPRQHSRKAKSRSISDVAVVSNPAMDPDDETGNLDSLTMIEPEAMPLTLRLFSHIPVLIHALGGDSSPLDIGVRVYVTSYLFS