lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp2 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSELYSTPQPFYYDKKSGFTQDEFKHAIDKSSTIYVGYLSFYTTEEQLYELFSKCGEIKRIIMGLDRNQKTPCGFCFVEYYSKEDAADCIKYINGSKLDERLIRCDWDYGFKEGRQYGRGLSGGQVRDEYRTDYDPGRGGYGKQRQFEMDQFSDVNGGDITYQQQILQLQQSQQQHQLYQQANAGGPQNYSGKRNRGADDDSDSFKRQRDNNGSISAGNTPNKGRFRERDEEDD
The following text describes a protein:
Function:
Involved in thiol transport from the plastid to the cytosol. Transports probably both glutathione (GSH) and its precursor, gamma-glutamylcysteine (gamma-EC). Exhibits some functional redundancy with CLT1 in maintaining the root GSH pool.
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MATTSRRFTTGLFASITSVKSHSANRPQSISLIRRNHIDHRLPLIVPSSRRWIIQAARSWDGFDDGAEAEIKKPGAYGYAIGDNEIEGSSSSTVHVIDGEHVKTAEIVIWAAVTAAFGVGNRVMYKLALVPLKEYPFFLAQLSTFGYVAVYYTILYFRYRAGTVTDAMLSVPKSPFLIVGILEALAAAAGMAAAANLSGPSTTVLSQTFLVWQIFFSIIFLGRRYSVNQILGCTLVALGVIVSVASGSGAAHSLNEAGVLWILLMVLSFLLQGAGTVLKEVIFIDSQRRLKGASLDLFIVNSYGSAFQAICIALLLPFLSKLWGIPFNQLGTYLKDGAVCFLNNGTITKGCDGAPFLPLLFVIMNIGYNIALLRLLKISSAVVSCLASTVSVPIAVFLFTMPLPYLGVASSLPKGFMGGTIILVLGMILYSWTPHGANSSHTDSVIPSPPPT
The following text describes a protein:
Function:
GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.
Subcellular Localization:
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.
Sequence:
MLLKQIFLPFFVLFNAINAIDIYQNQVSRGTIDLSIGAITIHSGAYWSIIDNAISALVGTLTVQQDAGFYITGLNPLLGLQVELLGVLNSIKNDGIVSFNGLNSLVGPIYNLVGLSFQNNGEFYLSASGVAPPVFSITAADWHNNGLLVLAQAKRTSALANLGFPTGSIENQGSICLFGTAYQQLTSITGSGCISADRDSTIYIFSSLLPIATTQTLYLADRASSIVIQPVTLPATYTVRGFGNGNKVGISLPLLSVPLLGQPAYSYDPSSGVLTLRGLGVGLLSQRFQIGTGYDSSLLEIVTDDGAGLPTTLLGSVRYNGPVPNNAVPASCNCKYVPPSPGTDESSSLSSSTSEQSSSSATSVSASETSDTSSTQESSLSSEVSSTQEPSSSTPEPSSSSETSSTQESSSTEGPSSSTDSSTEASSSESSTAPSSSAEASSSTESSTEEPSSSTEGPSSSQESSSSEESSTQEPSSSTKESSSTEGPSSTEESSSTEGPSSSTDSSTDITSASSTDEQSSSGTGQSSTEDEPIDSTESDTSSATDSSTATDSSATNTDTNSESTDSSTATDTSSTDSNTASSTETNTDVTDSSTDSNTGATESSTATDTNTDATDSSTVSETGATDSSTATDTNTGATESSTDSNTGATDSSTATDTNTSATNTDTNTGSNTATNTDDNTATDTSSTETNTATNTDGTETNTGTTETNTDTSASNTDDNTGSNTATNTGGTDTNTDTNTGGTDTNTGTNTGGTDTKTGTNTATGTNTGATETNTATNTNGNGTNTNTGATDTATNTATGTNTNTGATDTNTNTNTGATVTNTATNTGDVSATKDIPSPTSTDEGSNNGGGSNNGSGSNNGSGNGSGSGSGSGNGSGDGSNNGSGNGSDNGSGSGNGSDNGSGSGSGSDNGSGSGSGSGSGSGNGSGSGSDNGSGSGNGSGSGSGSGSGSDNGSGSGSNNGSGNGSGNGSGSGSDNGSGNGSGSGSGSGSGNGSGNGSGSGSGSGSGNGSGSNNNNGSGSGSGSGNGQDNGIITSSIGQPGSSTSTQGPSSSNSATIPEQANSGNHIKFTLFNGLLIGLVPIVFM
The following text describes a protein:
Function:
Exhibits Kunitz trypsin protease inhibitor activity.
Sequence:
MKATISITTIFLVVALAAPSLARPDNHVEDSVGRLLRPGQTYHIVPANPETGGGIFSNSEEICPLDIFQSNNPLDLGLPIKFKSELWFVKEMNSITIEFEAPNWFLCPKESKGWRVVYSEEFKKSLIISTGGSSNPSGFQIHRVDGGAYKIVYCTNISTTTCMNVGIFTDISGARRLALTSDEALLVKFQKAATPKADLKTKLRMFPFY
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MAWRYNSNSPPRGNVSANASLVSLSSANNNNRNFTDSADDNADTSALGNNNTFRRDRSAMDGAGAFLRSNAKGKMWSRQEGRDETPDDDVSSRDGTSPCSISFARPKLAPTESTTRPHRSLIFSRNPNRGVSGAATRSGMGSMSRLSVDSALNTPHRVASTRCVEGRVTSSSIANWRLPRHSGSPPINTGECNGEMTIISESGDFDEDATGGDPLLGCADRNLHRATEALLAEADPDLRATDFTPTKHVLQIVVKEDGTECSGAQIDERIAPLCGLQNRLDDMLGLHIQSHKDVFNKAIGRFSDIVLAVSDSNEVLGLLKQRLGMATSSLENRAEQLQVLRMRAAKALLMEESLKRMEAALASEREIKQLVASRHYLAAVRLLRQQKARLESPDMVNIRATQSMRDFANHTLETLHKNVLDGLMGCVFDKDRFSEADKQLMGRMVADGALENVAGTLSFMGDTCGALSSQCFTGGGGKNGDSDFVSLDGIVDDPCDEGMVKNHLHFIPLCVKTLKELGKLDQCCEAFRSGATRSIEQCVANFLSLYDTWRRDAESSKCVGNNDDMGSTVRILELQGRDVASCTVSHDEAVALIQQRDLCPLLNALFTELERVVRNADYLVRVVLLAYFPFLTDVPPRSEVFDDNFSCHEWDVTQSPLRTKNELRDIVVRTLAEAISRHSEDSVSSETPESRRLAALKRLMAKFDVDKALKGSSSHDAPTSKKGSLRQGSVDDGSIRCESNNAVCLGDVLTSLNAAAFLAVEEFPDGSEEVPACCERLSKAISSAVQDSFRSYMREIYLDWDLCALSSQLSYTVELVFKLICSNDAATSSKSDATAVNLSKQNLKHRRTTSRSWWQIDSIGGSHTNETFTSLDKMLSSHGSSGLLSAIEQIGGVSFSIVSTVNASSVEQVRAKDKKHLHSGAGTRIISSFGEVQGAAAPLKSAARLRNWFMFTPMNILACYDCTGHFFKRWKSYKLYFATVPVVEMTNFFQDFLERTYSPCLRAFHMMQLGKFLAEMPEPQGVHDGTESMGGPGDAGGTRANSSFATSTRQYMHHLKTQQEYMRWPTVTPGDNGCNGNAIHPVLTCVHYVGQVVQKLSRICRVLPSVLVDKIQQFLVQPLLIELNSFLKRKVQLITRGSLSHCLLNSDFDDAFHGTHTARWDALCDETRRGDSYEAIDMGLFRFYRYINARRTRAGADGDVEVVVPEEMQELFNHVRVKREKQHERSERRNEVFRSNGSLVSPISPRGAANGIQCEDVTAADLALQGDGIVVALALFCHSTEWLCGLLLRAFGPEGWCQHSDGDKLVPGAAFRERRRPPRKGVTPMQEGTEGWQHLGNFVDQLYTISQACLFHLLVEARFTAFQFIPQLSEHSYNIVAGAGTPDTFVQAYNRRMTNFFALLKPYLPSKRVKFVCLTVAKPLSDLFMLEISQLRDKVISTTGVSRLQVNLLAMEAALQLVLPTDDDVRESVKFHFARPATFVRYLSNGDVTDDLIASGDYKIFEVREMEELVRLVLKGDATASSVAEKIKLLHAGLEREQYDMISPLTTSPAITPNRKLPPVARGSSTGCKGHFPVSGSDAAAHEEPGELDNAKSPSSPQRRSANNKGTLKHVDPNSGGIIDPSLVNSDLKMPSSPGDAREVTESHSSGSEEGDEEEEYEEEYEEYEESDEYEESDDADNDDDDSSL
The following text describes a protein:
Function:
Functions as an intracellular glutamine sensor that directly activates the TORC1 signaling pathway, to promote cell growth when glutamine is available.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein.
Domain:
The FYVE-type zinc finger domain contributes to vacuolar localization.
Sequence:
MTTVHQLSGHGPLSRLNIYSGASPYTQRVRPSYELIEAPTRQATNGTGSVSGSPNSSSNSTPANQGSLPSHTNPQLYSSITRKERPELFRSYSGNPRLSKPYASSKLAASSRTASYQAMSYSVSPTSTNSSVATSLNYQSSRETGISKDHWKPDSDVSVCSFPSCSVRFGLFDRRHHCRRCGDIFCALHCDRNIPLTMDVKFCLAGSLYRSCVSCFYEYLKWKQSIDLASSNDITVIESTIAPQQATTHPPSQPKNAVSVPIPKMDSTDSKGELPSESLVLGTVPDNWVWSTF
The following text describes a protein:
Function:
Probably involved in iron transport into chloroplasts.
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Sequence:
MEARLSETLGLPSPNLNHCHFPNEFNSLFTHFSDLTSVQSPIVRNPKLKTKSSQKPPKFSANFRRSDPPFASTSISDPTHEKPGPEFLKWIKPASRSSPRIQTLIKQLSVWERAIIGAGAGGLAGAFTYVTLLPLDAIKTKLQTKGASQVYSNTFDAIVKTFQAKGILGFYSGVSAVIVGSTFSSAVYFGTCEFGKSLLSKFPDFPTVLIPPTAGAMGNIISSAIMVPKELITQRMQAGASGRSYQVLLKILEKDGILGLYAGYSATLLRNLPAGVLSYSSFEYLKAAVLEKTKQSHLEPLQSVCCGALAGAISASITTPLDVVKTRLMTQIHVEAVDKLGGAMYTGVAGTVKQILTEEGWVGFTRGMGPRVVHSACFSAIGYFAFETARLTILNEYLKRKEESEANVAADS
The following text describes a protein:
Function:
Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MWRATTRCLAATPAQSWALLGPGIGRRKTQSGPEQDRVPSRHHISKRSGAIRPRPTQMPFGLLRVFFVVFTFSCFGTLISQHIASLLKYFNVFDPEDDDDDDW
The following text describes a protein:
Function:
Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.
Sequence:
MNSRPAPPQPRPPQQQPQQPQQPQPNQQRLPFRPDESRARRLNQPLEQHANPINPSNFAAREYTEQEHKDIQTKLNKSLGPEFISYRDGPGGTRVQYIEGWKILNLANEIFGFNGWNSQIVSCQVDFLDTHGGSGKFSVGISMVVRITIRDGTFHEDVGYGSIENCRSKILALERCKKEALTDGLKRCLRCFGNVLGNCLYDKTIVAQMKKLKKFPIEFDPNDYYRDPLLVERERKKNIIEKQHEEQKRQQEDASRLDNSGQQVQHQQQNNSNVVSNGSIPVNGQQNHQNKGSDIVEPLEANQGNTRAGQVPQLSHHAAAFVTPKSPTKVVSYVPTSKEAEELDDSFMFSDDIFDGESQSIYYPPEVREHEQNQQQQKEENQGVARNGATKETTNNGRSENRPQNESMAVDQNPPVLMNAFVTAKSAEVLQQSPTVEAAAKNIVQFDPKFVSPNMRRTVDPTKSVPIKRSDIKNSVATTPSPLGVNTSSNRINKPMITSNNNNNINNMGKRIGMPPQPRTNKLVNSGNNPSSGIPHTVSTSVNGASGNENVENNSTIANTTVNQ
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
Subcellular Localization:
Nucleus.
Sequence:
MGITGLLPFVKNACRKGNIRELRGKSVAIDVSCLLHRGLTGCMDKIHMGEETQSYINYVDKYIQELLGMECHVVMVFDGRPLPAKKSTNDDRREMREKRKEHAEMLLAKGKEREARDHYRLATTISAEIVEKTIVFFRKIRNVDVVVAPYEADAQLAYLMQSKLVDAVVTEDSDLIVFGCETIYFKWQSVTGDCSVYQKSDLKKCFSGELGGEKFDFVKFRRICILAGCDYLQSGLPGVGLATAVKFFSLTSIKDLRILLRKIPSYLKNPKLKEHVNEEFIRGFERAENTFKHQIVFDPRERCQKPLTPYPAMDIDDELEILDFESPAESKSEISTKFEYAGTAETQRSSIRLALGNPSNNSKNSIDDRFLLIQPIPEWSIWGLRYESKGQEMQKLAKKKEEEAMECGGAFKLDSPSVVQKRPKIPGKIDKIDESDDIVAQFMAEIENEKQAMKKRKNAPASDYSAEHVLKKYAEPEKKRQKVLEVVDDDFSELFELKVPEKAKKVEILEKSPEKSAENELKPPPILRKSTSTPESSRKFQKFQSPLLSHQTSAPPAPKGSGSTEYAEKTGISKYFSRKTAENGPSKTKNPFRCPAFIKSEPKIEGKIEEQPKTQEKTVLSALEENCTATYRFVGFKSAGLRRKPKN
The following text describes a protein:
Function:
Acts as an activator of the phospholipid scramblase activity of XKR4. This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus.
Sequence:
MEKKIRSICISSYPGAIYFLQIAWKKDLGDGFTVALTDGHSAWTGEVSQEDVSQEAKDMEMERSNYVEELRKALIMTALPANKYNFDLLEDRENPEIYHFTYEKTLKEVAFKLGSTKLKSVQNPAHVIKELISYCLGCTAELYSRNEHLQKENERLQCDWNDMHAQLEKFVDGKEELEQTLYTQFTCVLNEKKAKIRNLKEKLSEAQERLKQKSEDSAPVDTLAASEMKYDAFGGSTDEEQESPAVASKTGKEHLLSRVLCCINACPSSGLVSKSNPAAKSQRRSLVIDDAPDVAPSRKRRQRGQKTFYTDVVANTTKTSNEETQRCNPAPAQSVGKTFSTEGTSSQTLKNTPDPDDLFSDI
The following text describes a protein:
Function:
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.
Subcellular Localization:
Nucleus.
Sequence:
MISTAPLYSGVHNWTSSDRIRMCGINEERRAPLSDEESTTGDCQHFGSQEFCVSSSFSKVELTAVGSGSNARGADPDGSATEKLGHKSEDKPDDPQPKMDYAGNVAEAEGLLVPLSSPGDGLKLPASDSAEASNSRADCSWTPLNTQMSKQVDCSPAGVKALDSRQGVGEKNTFILATLGTGVPVEGTLPLVTTNFSPLPAPICPPAPGSASVPHSVPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPLSFQPGTVLTPSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLPGVLASPELRSYPYAFSVARPLTSDSKLVSLEVNRLPCTSPSGSTTTQPAPDGVPGPLADTSLVTASAKVLPTPQPLLPAPSGSSAPPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLEREMASPPECSEMPLDLSSKSNRQKLPLPNQRKTPPMPVLTPVHTSSKALLSTVLSRSQRTTQAAGGNVTSCLGSTSSPFVIFPEIVRNGDPSTWVKNSTALISTIPGTYVGVANPVPASLLLNKDPNLGLNRDPRHLPKQEPISIIDQGEPKGTGATCGKKGSQAGAEGQPSTVKRYTPARIAPGLPGCQTKELSLWKPTGPANIYPRCSVNGKPTSTQVLPVGWSPYHQASLLSIGISSAGQLTPSQGAPIRPTSVVSEFSGVPSLSSSEAVHGLPEGQPRPGGSFVPEQDPVTKNKTCRIAAKPYEEQVNPVLLTLSPQTGTLALSVQPSGGDIRMNQGPEESESHLCSDSTPKMEGPQGACGLKLAGDTKPKNQVLATYMSHELVLATPQNLPKMPELPLLPHDSHPKELILDVVPSSRRGSSTERPQLGSQVDLGRVKMEKVDGDVVFNLATCFRADGLPVAPQRGQAEVRAKAGQARVKQESVGVFACKNKWQPDDVTESLPPKKMKCGKEKDSEEQQLQPQAKAVVRSSHRPKCRKLPSDPQESTKKSPRGASDSGKEHNGVRGKHKHRKPTKPESQSPGKRADSHEEGSLEKKAKSSFRDFIPVVLSTRTRSQSGSICSSFAGMADSDMGSQEVFPTEEEEEVTPTPAKRRKVRKTQRDTQYRSHHAQDKSLLSQGRRHLWRAREMPWRTEAARQMWDTNEEEEEEEEEGLLKRKKRRRQKSRKYQTGEYLTEQEDEQRRKGRADLKARKQKTSSSQSLEHRLRNRNLLLPNKVQGISDSPNGFLPNNLEEPACLENSEKPSGKRKCKTKHMATVSEEAKGKGRWSQQKTRSPKSPTPVKPTEPCTPSKSRSASSEEASESPTARQIPPEARRLIVNKNAGETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDTMKRFLSDHLSDLQGRAEGDPGVSWDFYSSSVLEEKDGFACDLLHNPPGSSDQEGDDPMEEDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERPGGLDDRSPPGSSETVELVRYEPDLLRLLGSEVEFQSCNS
The following text describes a protein:
Function:
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Also participates in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (By similarity). In addition to its role as a TCR coreceptor, it serves as a receptor for ITPRIPL1. Ligand recognition inhibits T-cell activation by promoting interaction with NCK1, which prevents CD3E-ZAP70 interaction and blocks the ERK-NFkB signaling cascade and calcium influx (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MQSRNLWRILGLCLLSVGAWGQDEDFKASDDLTSISPEKRFKVSISGTEVVVTCPDVFGYDNIKWEKNDNLVEGASNRELSQKEFSEVDDSGYYACYADSIKEKSYLYLRARVCANCIEVNLMAVVTIIVADICLTLGLLLMVYYWSKTRKANAKPVMRGTGAGSRPRGQNKEKPPPVPNPDYEPIRKGQQDLYSGLNQRGI
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Sequence:
MSKQSSLMSFFTPKGGSATPKTPIATGPPKVEADSSKKTVSTPKSTRAPLKRVNERMKMDEEDSNVVEKEPKRRRVIMSSSSEGESSDSDEYDPSKEKEDDDDEEFEDDSIDDDEETPKKKKSAKKGGRKILEKKNDDDVEEEEEEKGGAESDGELCFDAAMATSFIGSFVMKDDDISEKVKELLDAEVTVDPKNIEEEEMPVEKKKKGEKEMDDDEKVDEYAHEKLDFLKPDNIRDMCGRRPDHPEYDPTTLKISDQFLKDQTPGHQQWWTIKSFNFDTVLLFKVGKFYELYHMDATVAVNCLNLAYMKGNYAHCGFPESAYGRFADQLVQRGYKVARIEQTETPDQLNERNKKEKVKSKVVRRELCRITSVGTRTFDALDSPLDDGKTEDGGEMTIGDTNTAYLLAIKEVIMTRGGARVTTFGVAFIDTSIGRFSVGSFDDDCYFSHLRTLIARHPPVQIVMERNKMSPSTRSVLTSMLPSSVPIESLTPKKEFLEPEKTITMLLDRSRLGGDTSSWPLTLREMLSKDESLPTSTLNDREAWSALGALISYLGRCLIDVDMVTMKQFDRFDPTTVSVKSLSSSTLSTTAWKGRRMVIDGVGLEQLSLIPLDYASEQTSGSLYSILNRCNTPFGGRLLRSWVCAPSCDKEVIEERQKAVEWLMTSDGKKCHSKVEELMENLPDLERLLQKIHCVGLVHRAREHPDSRAVMFEGEKYAKKRMKDLIIALEGFKLCQKIGELCEVWRKGEKRNRLLAAAPFNVKKHIEHFESIFNVKDAESSGKIIPIEGKDAEYDAAKERVESIKERLDEYCKKIGMKYQCKATLVNSGKDRNLIELPDKVKVPTEFDKKTMKKGFVRYTNADLLSLNCELNEAESDVECLLKDATRKVFADFDERKCSWQNALDAVSTLDVLISLSKYSQSTGVTMCTPQFVYGEEKPVFEVVDSYHPSIIITGLASLSDEGIETSSTTFVPNDITLGGCGPSTLLLTGPNMGGKSTLMRQVAVLTVLAHMGCMVPAKKMRLSPVDRIFTRLGASDRLVAGQSTFFVEMNESAIALRDATKHSLAIFDELGRGTGTLDGQSLAWAIMHQMTKRIGARAVFSTHYHGLCERLDGDKDVLQMHMGCVVEDEDETTEVTKEAVTFLYRLIPGVCPRSFGFNAARLAGIEEHVIRDSWSAAKRIFGDAKALKKLREEAENGANVETLRRLIQAAF
The following text describes a protein:
Function:
Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
Cadherin 1 to cadherin 4 domains mediate homophilic trans-interaction, the interaction with an identical protocadherin expressed by a neighboring cell. This is a head-to-tail interaction, the cadherin 1 domain interacting with the cadherin 4 domain and the cadherin 2 domain interacting the cadherin 3 domain of the other protocadherin. The cadherin 6 domain mediates promiscuous interactions with protocadherins on the same cell membrane. Each cadherin domain binds three calcium ions.
Sequence:
MVNLRGYNWKSQQLLLFLIIVAAWEAGSGQLHYSVPEEAKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVEVKDINDNPPMFPATQKALFILESRLLDSRFPLEGASDADVGSNALLTYRLSTNEHFSLDVPPNHEQVKPLGLVLRKPLDREEAAEIRLLLTATDGGKPELTGTVQLLITVLDVNDNAPVFDRSLYTVKLPENVPNGTLVIKVNASDLDEGVNGDVMYSFSSDVSSDIKSKFHMDTVSGEITVIGIIDFEESKAYKIPLEARDKGFPQLPGHCTILVEVVDANDNAPQLTVSSLSLPVSEDSQPGRVVTLISVFDRDSGANGQVTCSLTPHIPFKLVSTFKNYYSLVLDSALDRETIANYDVIVTARDGGSPSLWATASVSVEVADVNDNAPLFAQPEYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVGERLLSSYVSVHAESGKVFALQPLDHEELELLQFQVSARDAGVPALGSNVTLQVFVLDENDNAPTLLGPLANGVGGTMNEVVSRALVPGQVVAKVRAVDEDSGYNAWLSFELQPVAGGVRSPFRVGLYTGEISTTRALEETDALRQCLLVLVKDHGEPSLTATATVLLSLVDSGQTQKVSSKVSAGASRVDQRLVDVNVYLIIAICAVSSLLVLTLLLYTALRCSATPTDGACAPGKPMLVCSSAVGSWSYSQQRRQRVCSGEGPPKTDLMAFSPSLPQGPSSTDNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
The following text describes a protein:
Function:
Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Midbody.
Sequence:
MATGDVEGNLERLKAQLRSVSYPHAIDNQGLRMGLPSAVLPLLHHALLGYSRHVFRYLSTNGYELYAKSDLRFIECILKFLRTEFGYRCSLTLAQIFSKGFSERKMIFVHDVVQSESVMSSRHKRISRNEEVNEERKSPSLRIKTTSSPRCKNKLPSISKMCKLAIELSPTPRLTFEQPGIQADHDEMEDRSSPCYIPDNEKQAEADFQVKSPTQIGGIDSSLPRELDRGIRKSPDASLPRTMDTHKSLSSEMTSRKCSISPSTSEDDEAAPVVSKNVAAITSCYDEIKLKIGEIAEKLGSRFSTLEESLSKTTQTLEARFCTLESRIRLLEKSFFPKARQSPEKNIQFCKKHSPRFQFELRSGRKVDEPIRDISNMNLRHHSDVHPSHRANLTTQQLIDSIKARCQKTKELLSGIY
The following text describes a protein:
Function:
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
Subcellular Localization:
Mitochondrion.
Sequence:
MVAAPFLRSFPQAVRSNRPRAAVDAAKRLGVRTGRTTISDKICVLRSQYEAKGFSTSTSRWQEKILDRTRNIGIIAHIDAGKTTTTERMLYYSGFTRRIGDVDEGSTVTDFLPAERARGITIQSAAITFHWPPTAGESDKQEVQTPRSASSHTINLIDTPGHADFTFEVLRSLRILDGAVCILDGVAGVEAQTERVWHQASTYRIPRIVYVNKLDRDGAAFGRTVREVGSRLGAFPAVCQIPWFENGNGRFVGVADAINLQGLRWEEGDGKVVKMLSLEQLDAEEAQLGKELRRARIALVELLSEHDEAMVEKFLECDENHLAVPPQDILESLRRCLLEESGSNIVPIFAGASFRNIGVQPLLDAVVNLLPSPLEAPDPEVSIGGVQGGLQRLLSGELLVESGEKSQSPKGKQRKSVAHAESQNVMKNLQGCALAFKVVNDAKRGVLVYVRVYSGSLDRNCVLFNTNLNVSERAPRLLKMYANDAVEVDSIPEGHIGVVVGLKHARTGDTLVSYAGNKATPPKPLNTLQLRPINVPPPVFFASVEPHSLSEEKKVQECLALLLREDPSLHVAVDEDSGQTLLSGMGELHLEIARDRLINDLKAKATMGRIEIGYRETPLGPSPAVTKIFDKEIAGRKGKAGCTALVEPFNRDTSPAPEPDALAVETRDGNQIIILAPDLQIEHTKKGTEESPFLPPGLDVHTLRTALQNGCLAALARGPQFTFPMHSTRVTLTLDPATHIFGTDTTPSALSAAARLATSAALRDLLPSPTQPRPGTSLMEPVMNVIISVDEASLGAVVHDISASRGGHIISLDEDIPITATDASPMGAGAEEPVIIDQSRIYAPPDPFETPSVGVEIPAAVNRPRTITAKVPLKEMVGYLKHLRSLSAGRGTFVMSVDRFELMSAQRQKAVLAELRGGFY
The following text describes a protein:
Function:
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Miscellaneous:
MISCELLANEOUS: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
Subcellular Localization:
Cytoplasm.
Sequence:
MKILWIGRTQYAEAWRLMKSLHCAVAQGLTGDIALVTEHEPVVTVGKHGRLNNVIKWDVPVYLVERGGDATYHGPGQAVVYPIVALRWPLKRYIDAIEDAVIKTLGTYGILAGKKQGHRGVWVGDRKIASIGIAVENNVAYHGVAINVTIDPREFARINPCGLPASTMISMKELGVVAEVRDVGIETAKKLALELGLTPELISKPPEVPQVAEELKPVRVAINA
The following text describes a protein:
Function:
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
MPRTKRVYSGKTITGVLYPVAICMLFVAINVKLSQPEQQEQSKVVYGLFHSYDTADSGTITLYLIGFLILTTSLGVFCYQMKFYKAIKVYVLANSIGILLVYSVFHFQRIAEAQSIPVSVPTFFFLILQFGGLGITCLHWKSHRRLHQFYLIMLAGLTAIFILNILPDWTVWMALTAISFWDIVAVLTPCGPLKMLVETANRRGDDKFPAILYNSSSYVNEVDSPDTTRSNSTPLTEFNNSSSSRLLESDSLLRPPVIPRQIREVREVEGTIRLGMGDFVFYSLMLGNTVQTCPLPTVVACFVSNLVGLTITLPIVTLSQTALPALPFPLAIAAIFYFSSHIALTPFTDLCTSQLILI
The following text describes a protein:
Function:
Sesquiterpene synthase that catalyzes the formation of sesquiterpenes and sesquiterpenoid alcohols. Converts farnesyl diphosphate (FPP) to 10-epi-juneol. Converts FPP to tau-cadinol. 10-epi-juneol is the major product.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MATQKSTTALDAKSKMTTDLVRPLANFPSSIWGDRFMSLSIDKSELKTYDKVIEKQKQELRRLIIDPSMDSNKKLSLINSVYRLGLTYLFEEEIEGQLDKLFKEIDMQEACNEADLYTISVNFQVFRQHGYKLSCNVFNKFKDYTSDHKFKEYIMADVRGMLGLYESTQLRIRGETILEEAFAFTESQLKGVLDTLEGNIARQVKHALTSPFHRGLRTVEARIYFSNYEEECSTYDSLQKLANAHFNYLQLQHKEELASVIKWGEDMDFKTITPYARDRIPDLYLWGLGLFSEPHYSQARILISKMAQLICVLDDTYDAYATIDELHLLTNAINRWELSATEQLPEYMKPLYKVLLNEHVELEKQLSSKGKSNFVNASKKAFQELAMGYLQEAEWRHNGKVPSFQEYLKNGLITSTYNVFAKSSLICMSDIVTEEACTWYDSDPIILQATGLLGRVYNDISTFQFERKRAQQQITSIEAYMKTFGVPENVALEELKKMVEIAWNDINKGCLNTNEISKKLLAPIVNLARMTDVIYRYNDKFTFPEKTIEEYITLLFCESIPKN
The following text describes a protein:
Function:
Involved in cytokinesis. May hydrolyze GTP.
Subcellular Localization:
Cytoplasm.
Sequence:
MDRQSVVKSTAIPFPLNFDNEKYDDMYKAYNKIMVLARDLNAFIETPEFVFIGKDGNGKSALIESFIGFPMMIGEGSSLRPLHITLMNNARCEEPIVTFKRDRSLDSYEFDRQIELSMVSSEISKRNQKTSIPIEITIEYRYYLNMLLIEPPSVSIQPTNAITIQGQSMTSPANQLANKIAKLSIGNEMGEMITQYTKSNNRTLVFVETSTNGGTNSSEMLELAKKLDYKLDRSIFVFNKFHSLLTGDQPFTNGRDANRFLGSPSIGAPTFFTTLPSTAQRSQCNSKDQLSQLCDQLQQTDLNILEQLQFDKKYERNVGLSAFRHWISEFTWRKYLDSVPEVLKRLNSFRTTSEDQLYQIRQQLERTNAVTLRQIANSYVSIEFIQCIEKLVTRTLEGNPSLNGQTLEEEKSQDETGDWYDHNGKPILLLNDEKLVTFYDNKLYGGQQFERLLTEFKCITEVIQLEELSISEVACAIGSNRPSNASVIAWAASDLAQKKIKEALLPLVDQLFKRATYILRRLVDIVDRMIENKKKSSFRRHGNSTSLFQDNSSPSSQSQSQSSSISQSASLSSENMIYGIQSINGSDSVSRPSHENTIVNVEDHPYFIYSVKEMYFKYVDQIAADCKNKCMDEFYTTRLIYWDLQSNKDLKKFCTDSPCVSLNNSLNNNNKSTTPGNNNNNNNNNSNNNYNNSNHILNPKETHTMVTELASKLFQDIRNRMSKNIMLKCYNYFLIPMQMDLKLNIQDNITKLSDAMLEEIFEIQTTKERLREDEQHLAQICNQFIQQEENYKKYSQSFSHPFPSAVRN
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
KFIMQKFGKKRKVDSCPNRLFLSYLKEWKDDASEKELKSYHTYNKAYKSLEKYGLPLQSGKEAVILANFGEKICAMLDTRLGKDSKEKGVTPREFLEQSRQVSESWWKSLETEPNKKKQKTLKVNSNRTYVPVKNSGAYALLIALSRNKASENSFGYMKKAELQREAQTFCTKSFTVPDPGSQYTAWSSMATLINKELVKKHNNPAKYEITDSGLELAQKLDIENQNKGITNTGLDSDEEISQEIKSTVPNSNPQCSLAHSSGGNVEFCLEPGDFDVVLCVDTREVSGDKRKKEMQREIQKLNVETIDRVLQIGDFVWVAKEKSYTGNGREIVLDYIVERKCMADLAMSIRDGRFHEQKIRLKQCGAKKIVYLVEDMNKIQHQSLPEKTLRQALINTQFVDDIFVKYSENIAATAQYLGILTTKLKKMYRNKTLLACEIAEVQKTCNDENSVQKLLSFDDFNDGSLKGKGLTITEMFVRQLMQLHGMSYDKADTITQLYPTPYLLVQAYKNCESLKQKQDLLAKIKTGLLKRNLGANLRKSIYSAFPDFAPIS
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of the ketose sugar fructose to fructose-1-phosphate. Does not produce fructose-6-phosphate. The sugars D-glucose, D-galactose, L-rhamnose, D-xylose, L-arabinose and D-ribose are not substrates of this enzyme.
Sequence:
METPDETTVRAADSCRESLPERVDGGRVLFGFDGYIDRVREFVSERQSADTYERVPTLDAFAERVNDSVEAESSLTFEWIQDGVRTGGHVSHLARAFDRMGFEPGVVGCLGDPVEEPFVEEFGHLPLETLGSPGYTDAVEFGDGKLMLTEIGALMTLDWAGIESRVGLDRLAELVDGAELVGMGYWSEMPELPDVARGLREELWPTLSDPPETLLLDPGDLRKRGPDVVAAGVEQVSALDDAVRVVVSANRYETRYLARLAGVESDDFGRESQAAFDHLGVSRFAGHGIEEAHLVDEAGTATVGVPRTDDPVLTTSSGDHFNAGLALAHVLDLGRAESLVVGNAVAGHFVRTGSPPTYDELRAFASGYLDYFDAA