lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular Localization:
Cell junction, desmosome. Cell membrane; Single-pass type I membrane protein.
Sequence:
MARFSVTDVSLLLLLLFLVISAESTKTGTKTLRRMKRNWLPPPAKLIENTDYSHVKYIAKIRSDKDQKQKVEYYLKGEGADEPPYNLFVVDHVTGLVRITNTVDWETHHSFHLKGIAKYLNGTQAEEEIPLIFTVVDQNDNAPYFEPHYGSVNESSKKDTYIMQITAKDKDDPTTPNAEIAYSIISQEPALDRHMFRIGKKTGKLYVKEPNLDREAHDFYKLVIKATDMGGAPEGLTGTGTVEIKVLDINDNIPTLEKSEYDGTVEENVADVVVMKIKALDKDEKFTDNWLAVFKIEKGNENNLFSIETDNKTNEGILKLIKAVDFEEVQNLELGLVIGNVAPFVEGGPLTMDVDVVVGEGDTAGAGAGAGAGTGAGAGAGAGAGAGAGAGAGVDLGLDGDLGADLDLDLDLDLDLNVDGELEGDLGLDAELGPGVGVKPAGGVNPNVGLKPGPGVGVGVNPNLPSMPVKPGQKPNKKPKPKPKPQPKPKSYPIKIAVKNVPEGPAFIPTIKEVPVSEDKNTLPEDGVITVFAAVDPDTKKPAEDVSYAKGLDPDNWFTIDEKTAEIKLNKVPDRESPFLVNGVYMAKILAISKDMPPKTATGTIAIKVADSNDNCPILTSTHSSLCSDKKTVFVTAFDGDVDPNATPFSFNIVPEGTQGGWDVELVNGTTAALHSQETLWPGVYELQLEVRDAQNLSCPSSEVFTVDVCTCEGTEDCSLNVGRLRSKSTEVSLGAIGLLMMALCLLLFVPLFLILCQCGGADKVFPDQFSKLPFETTEYLIVYDTEGKGEDKELPLHSVPVGSTKNPDGTAFMNFNTMSSAYTNTAHMHTVKGSVNMFGEGTGLIETDSSPGFVREDLLHGSAAFGIQTFMQDTAALDEDMALPDDFLDSYYSQKSMCDFPIKDTLMEYDHEGQGSSANSVGCCSLLDSDTDLNFINDLGEKFKTLAEICSPPSITVRSSVTKATPDVLRTTSDVVQPVLRPQVKSVVVTNKSGINTETSVSSTKVLASSSSKVSRASSCKTLPHHSHITNVGRSSDIGRSSDIGRSSYLGRSSDLGYSSDLGRSTDLGRSPDLGYSSDLGRSTDLGRSSGLRRSATLHYPSQRVVLQQPLYYTTNDVMQPMQYVMAPNPQNTLMLDNWSSGTNLSGLVLINGSQGPSGPLISEGPDSLSGLVTSSTQSFVSLQSPVSPTSPVGAAMYVSAPPGSGDGSSSLDSWGMMAPNSGGSFMLLSNNVLEEENPGPYQGILPRYVNLENEAVPLQRVCNVAAQVTIFPEHFAVAVKHSSIKFPIIWDRKLNLKKTGFVLGKNRKTRLQQIMAQFWFSFLVTLYLFVWGGYKDIYRPTFYKLRPA
The following text describes a protein:
Function:
DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).
Subcellular Localization:
Nucleus. Note=Located in nuclear speckles.
Domain:
The C-terminal zinc finger domain functions as a transcriptional transactivator; The BTB (POZ) domain possesses repressor activity.
Sequence:
MSLPPIRLPSPYGSDRLVQLAARLRPALCDTLITVGSQEFPAHSLVLAGVSQQLGRRGQWALGEGISPSTFAQLLNFVYGESVELQPGELRPLQEAARALGVQSLEEACWRARGDRAKKPDPGLKKHQEEPEKPSRNPERELGDPGEKQKPEQVSRTGGREQEMLHKHSPPRGRPEMAGATQEAQQEQTRSKEKRLQAPVGQRGADGKHGVLTWLRENPGGSEESLRKLPGPLPPAGSLQTSVTPRPSWAEAPWLVGGQPALWSILLMPPRYGIPFYHSTPTTGAWQEVWREQRIPLSLNAPKGLWSQNQLASSSPTPGSLPQGPAQLSPGEMEESDQGHTGALATCAGHEDKAGCPPRPHPPPAPPARSRPYACSVCGKRFSLKHQMETHYRVHTGEKPFSCSLCPQRSRDFSAMTKHLRTHGAAPYRCSLCGAGCPSLASMQAHMRGHSPSQLPPGWTIRSTFLYSSSRPSRPSTSPCCPSSSTT
The following text describes a protein:
Function:
Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not. Required for rhea/talin correct cellular localization in the midgut. Required for many embryonic (dorsal closure and somatic muscle attachments) and postembryonic developmental processes (attachment between cell layers of imaginal disks, organization of ommatidial arrays and flight muscle development). Involved in the function and/or development of the olfactory system. In the testes, essential for shv-dependent maintenance of somatic hub cells and their localization to the apical tip. Plays a role in timely border cell migration during oogenesis.
Miscellaneous:
MISCELLANEOUS: The absence of the beta-PS subunit results in detachment and rounding up of the muscles, thus the gene encoding beta-PS is called myospheroid.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Lateral cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Note=In ovary, localizes to the apical, lateral and basal membranes of follicle cells through oogenesis stage 10A. Apical membrane expression peaks at oogenesis stages 9 and 10A in columnar follicle cells overlying the oocyte but decreases in the most posterior follicle cells. Thereafter, it is down-regulated. Localization to lateral and basal membranes persists during dorsal appendage morphogenesis. Localizes to the cell membrane of migrating border cell clusters during stage 9-10 of oogenesis; cell surface localization is dependent on Aldo-keto reductase 1B (Ar1) and may play a role in cluster morphology.
Sequence:
MILERNRRCQLALLMIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQTEGCAWCMQPDFKGQSRCYQNTSSLCPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQSSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMEDDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKKLEHPCENCKAPYGYQNHMPLNNNTESFSNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATGDVKITYFSSCLSNGPEVQTSKCDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGSIGYQVQANSCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGACECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDTCMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTGELKNGDDCARNCTQFVPVGVEKVEIDETKDEQMCKFFDEDDCKFMFKYSEQGELHVYAQENKECPAKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYKQATSTFKNPMYAGK
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MWPHSRLRTPLDVDLVYSRLGFFIESWKAAKGPDTEKLQSCGGILMGEVPTRAGNKPLHDFLFGDRLIETLIFITPTTITFICSPRQAEVLAPLAKPRQDQSKHICVKLLVKLAEPKSGNSWMKDLLTSVEAVISNSKKIGRMSKDQSWAGWRSFLKSEGKGALYEDATIISNEMSAILAIKHPEEIKRTEIACQMSLQLMSLLSKHLISLIEEGEEITSQKIAQFIREKHNDGSYWEEAKFEPDFNKQDAILRSLPVIRAGGDSWRFRKSDPIGAEQLGNTGVFLADLGIQYKSYGSYIRRSLLVDPHPTQQENYSYLLELHRFALTELREGVTGHEFYALVSRKAKSDRPGLHLPHIFGSSLGADPQKRLLNLTKNCSAVLKRNMVFTLSLGFLNITDPFDRRSKYSLHITDTVCIGENGSIILSDGLREPSDITFFVNSDPSKTDQVKVEACSQNSKKVHSSRGREVVLKRSGSSGEERKRQKNSPAPSSNDSDCPGGDSNVGIDTKPRVSSEYSTAKKRAGLGHGDIQPMKNRGNEQKSTRANKSETPDVDKRLDVLKQAEDSMMKGLTDLENKLNDSKSQIKENFAELRKSVATDSPTDHQQRMLKFQEEWTTENHQVFQEIGKLE
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase: part of the gene cluster that mediates the biosynthesis of domoic acid (DA) and derivatives, natural products with neurochemical activity acting as ionotropic glutamate receptor (iGluR) agonists, thus being neurotoxins causing amnesic shellfish poisoning (ASP). Catalyzes the conversion of N-geranyl-L-glutamic acid (L-NGG) to N-(7'-carboxy-7'-demethylgeranyl)-L-glutamic acid (cNGG) via three successive steps involving N-(8'-hydroxygeranyl)-L-glutamic acid and N-(8'-oxogeranyl)-L-glutamic acid as intermediates.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MNIATASLCAGLAVSGKFLSKYYQFLSTSQSDEVGFIEIMNMGMTGNDAVACASLGFVMYCVLSFARSYYRFRFSPLRNAPGFGPKSFVYGMFYEFLEAPFMEPPIEALKKLRKGGNDIPFLAYTTLFGSQRLLLLDCDLIKQVFTAPSGRDPMRYPKHYVYLREVVGDGLVVVEGSEWSRHRRIVQPAFQSAFLRDAITTTVPTLVENLVDVWKKTAGTSINLNAHLSIITLDVIGKVAFSHEFNASKLLNEWAECPDKELGEVDDPLISSIGAAFSSSPLKLMLTVLKQPWLEKHLSPAFRTSRNLLNKAADDIVQNAKNIDDPKRRSVLNLMMEAKDDESSKARNKLTDTELRDEVKTFLVAGHETTSTWAHWSLYVLATRPDIQEKVFADITKHSPDDKTILLEQADQMEYLWAFMNETLRLYSPLGLISRVTHKEENFKGYTIPAGTNLRIPIHLIHRHPDHWKDPEDFKPERWFDTEESSKRHKFAFIPFAAGGRNCIGQRFASMEAKIIVANVAKNFEIHLADSMKGKKITFSNFISLKCKPEIEIYVTPRG
The following text describes a protein:
Function:
Catalyzes the formation of the alpha-1,6-glucosidic linkages in starch by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position. Essential during embryogenesis.
Subcellular Localization:
Plastid, chloroplast stroma. Plastid, amyloplast.
Sequence:
MVSLSNQTRFSFHPNNLVVSEKRRLGISGVNFPRKIKLKITCFAAERPRQEKQKKKSQSQSTSDAEAGVDPVGFLTRLGIADRIFAQFLRERHKALKDLKDEIFKRHFDFRDFASGFELLGMHRHMEHRVDFMDWGPGSRYGAIIGDFNGWSPTENAAREGLFGHDDYGYWFIILEDKLREGEEPDELYFQQYNYVDDYDKGDSGVSAEEIFQKANDEYWEPGEDRFIKNRFEVPAKLYEQMFGPNSPQTLEELGDIPDAETRYKQWKEEHKDDPPSNLPPCDIIDKGQGKPYDIFNVVTSPEWTKKFYEKEPPIPYWLETRKGRKAWLQKYIPAVPHGSKYRLYFNTPDGPLERVPAWATYVQPEDEGKQAYAIHWEPSPEAAYKWKYSKPKVPESLRIYECHVGISGSEPKVSTFEEFTKKVLPHVKRAGYNAIQLIGVPEHKDYFTVGYRVTNFFAASSRYGTPDDFKRLVDEAHGLGLLVFLDIVHSYAAADQMVGLSLFDGSNDCYFHYGKRGHHKHWGTRMFKYGDLDVLHFLISNLNWWITEYQVDGYQFHSLASMIYTHNGFASFNNDLDDYCNQYVDRDALMYLILANEILHVQHPNIITIAEDATYYPGLCEPVSQGGLGFDYYVNLSASEMWVSLLDNVPDNEWSMSKIVSTLVANKEYADKMLSYAENHNQSISGGRSFAEILFGGVDNGSPGGKELLDRGISLHKMIRLITFTSGGRAYLNFMGNEFGHPERVEFPTQSNNFSFSLANRRWDLLESGVHHHLFSFDKELMDLDKSKGILSRGLPSIHHVNDANMVISFSRGPFLFIFNFHPSNSYEKYDVGVEEAGEYTMILNSDEVKYGGQGIVTEDHYLQRSISKRIDGQRNCLEVFLPSRTAQVYKLTRILRI
The following text describes a protein:
Function:
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Sequence:
MKRQLALGTNNLNKVKEVSSILMELGIQILTPKDLKVSFNPEETGSTFKENALIKAKELFYLTKIPSIADDSGICVSALKDEPGVYSARFGGPELNDEGRALLLLEKLKGNQNRKAYYACAIAYVDESTEQSFEGRCEGLISEEYDRIGIYGFGYDPIFIFPPLQKPFSQIQEETKNSVSHRKKALDELLKFLKTKP
The following text describes a protein:
Function:
Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MLSVFGLRTVARCNSTLASGGARAAAAAGGKAGAQYSALPKSVHALYFQPLKLPVKHHDLVADLQLRAFDNQSLDFFANFALRVGYYLGIPMTGPKPLPTRRERWTVIRAPFAHAKSKENFERHTHKRLLRLWDANPEVVEMFLSYITKHSMAGVGMKCNMFQRESVQLAQELADVPLAPGAPQTADEVVGAKVAELMQSPEFKKHL
The following text describes a protein:
Function:
Mediates nucleation of actin filaments and thereby promotes actin polymerization. Plays a role in the regulation of actin filament length. Required for normal sarcomere organization in the heart, and for normal heart function.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, M line.
Sequence:
MSYFGYRRELSKYEDVDEDELLASLSPEELAELEKELVDIDPDANVPIGLRQRDQTDKTPTGTFSREALMKYWENETRRLLEDEIEGGSPKLDEGQEREFVTQGSSEEEDEKDKNEKEQKKSIESNEDEEEGCDEEEDEDIEEEEEPVTEDDEEEEEEEEQVKSEPMKHSELGRALVIKPPPVKPAVVESASPTPPGDPNTSRNPTVVDDVLQRALNNDAELTEINLNNIDDISQETLIRFTEALRSNTNVRVFSLANTRADDPVALAVAKMLKENSSITSLNIESNYVTGKGVMALVQALPANNTLTELRFHNQRHMCGGQVEMEMVKILRENCTLIKLGYQFNLPGPRMSMTGILTRNQDRQRQKRMQEQRQQQQDQQRIQNAAVNPRTSALRETPSSSPHGSPRGSPWSSPKLPQSKQVSKQTPPAPPPPPPPPPLPPPAPKQEVKKKKPTRMIAEVIRAHEAGSTKATKPKGKKGKKGREKEETSSILKELKNALRPVSADRKEGESSRPSTPMRSAHDQLMESIRTSSIRSLRRVEIPHHLK
The following text describes a protein:
Function:
Pollen tube attractants guiding pollen tubes to the ovular micropyle.
Subcellular Localization:
Secreted. Note=found at the micropylar end of the female gametophyte, possibly at the filiform apparatus of the synergid cell. Difuses to the surface of the funiculus of the ovule through the micropyle.
Sequence:
MKCPSIFLTLLIFVSSCTSILINESSDEQRIYSFSPTTSPFDPRSLNQELKIGRIGYCFDCARACMRRGKYIRTCSFERKLCRCSISDIK
The following text describes a protein:
Function:
Atypical bHLH transcription factor probably unable to bind DNA. Negatively regulates brassinosteroid signaling.
Subcellular Localization:
Nucleus.
Sequence:
MSSEQGNGSNPSTSPEVEGTKTIPFRRRLQRGQRVFAPKLMEALRRSRVSSEEAPVRHLSRRWRATTAQKVYSLKLYDALQRSRRSATVRDTADKVLATTARGATRWSRAILVSRFGTSLRRRRNTKPASALAAAIRGSGGSGRRRKLSAVGNRVRVLGGLVPGCRRTALPELLDETADYIAALEMQVRAMTALSKILSELQPSTNLGSAL
The following text describes a protein:
Function:
Essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to activate the pathway.
Subcellular Localization:
Nucleus.
Sequence:
MKRSTTDSDLAGDAHNETNKKMKSTEEEEIGFSNLDENLVYEVLKHVDAKTLAMSSCVSKIWHKTAQDERLWELICTRHWTNIGCGQNQLRSVVLALGGFRRLHSLYLWPLSKPNPRARFGKDELKLTLSLLSIRYYEKMSFTKRPLPESK
The following text describes a protein:
Function:
Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Sequence:
MLLKSLALIASSSLAATFNIGDDLFADPQFTVQFHNRPLRQADVQNGLLPHRDPVYGHPLGYEMMQFNGTNHICGIPEVTTTKSSKSREEGELSPTEARDRALELMLPLLGDCLFYEQGFFSYRFCYGSGVVQYRRHGDNYFPRIYPPPQADDSPTFVLGSFEKDDTTNTVTSAGGIPFLAHRLRSGTHCPLTGANREIEVQFVCDKNVQHDHILWIKEKRTCNYVMQVGTPRLCKDMRFQPPPDESLPIMCYSVESEAPEFETIDGMFDGVAHVKEEQEAVSARAHQFVGSNVNKDKIDEIEVAWRFTKARALNYIGVWLGDCVNRQTLFKELGIATPSHDAPFIIQTRSMFVPAPINRHFEVRLMITRQQLLLSINDDDVTLEEKYAWWQEQGDMSNLEIQGLTMLDDAGIEDVLARATDEVMKQLNKEAKQSKKLAKKKEAASTKREEAKKQVEASVEEKAVDSAEDDGTDTVTSTQTFFRTQTLSTAEAESKQMPDKAEEDEDEDLIVTMYFEDGEFKIEGFEVADFEGVKSAMKDLADKEDDDDDYEDYGLSD
The following text describes a protein:
Function:
Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MSKLQLRAVVADRRLDVEFSVSAGEVLAVLGPNGAGKSTALHVIAGLLRPDAGLVRLGDRVLTDTEAGVNVATHDRRVGLLLQDPLLFPHLSVAKNVAFGPQCRRGMFGSGRARTRASALRWLREVNAEQFADRKPRQLSGGQAQRVAIARALAAEPDVLLLDEPLTGLDVAAAAGIRSVLRSVVARSGCAVVLTTHDLLDVFTLADRVLVLESGTIAEIGPVADVLTAPRSRFGARIAGVNLVNGTIGPDGSLRTQSGAHWYGTPVQDLPTGHEAIAVFPPTAVAVYPEPPHGSPRNIVGLTVAEVDTRGPTVLVRGHDQPGGAPGLAACITVDAATELRVAPGSRVWFSVKAQEVALHPAPHQHASS
The following text describes a protein:
Function:
S-acyltransferase involved in protein lipid modification. Catalyzes the palmitoylation of proteins peripheral or integral to the tonoplast. Required for the tonoplast localization of CBL2, CBL3 and CBL6, but not for the plasma membrane localization of CBL9, for the endosome localization of RABF1 or for the endomembrane localization of RABF2B.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Note=Transient expression results in mistargeting of PAT10 to the Golgi apparatus, while the non-functional mutant is also localized in Golgi apparatus membranes.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MGVCCPFLQPWDRARDQCLLNLPCLSDPVRRSSLLLKLALVALHLVFIGFLFLFDAEFIEKTKRDPWYMGCYILLFSATLLQYFVTSGSSPGYVVDAMRDVCEASAMYRNPSTTSIQHASRKSESVVVNVEGGSASCPRRPPTPWGKLVLDLYPPGTSIRNLTCGYCHVEQPPRTKHCHDCDRCVLQFDHHCVWLGTCIGQKNHSKFWWYICEETTLCIWTLIMYVDYLSNVAKPWWKNAIIILLLVILAISLIFVLLLLIFHSYLILTNQSTYELVRRRRIPYMRNIPGRVHPFSRGIRRNLYNVCCGNYNLDSLPTAFELEDRSRPYTCIDMLKCRCC
The following text describes a protein:
Function:
Thiosulfate sulfurtransferase which catalyzes the transfer of sulfane sulfur from thiosulfate to cyanide.
Miscellaneous:
MISCELLANEOUS: Present with 4220 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MFKHSTGILSRTVSARSPTLVLRTFTTKAPKIYTFDQVRNLVEHPNDKKLLVDVREPKEVKDYKMPTTINIPVNSAPGALGLPEKEFHKVFQFAKPPHDKELIFLCAKGVRAKTAEELARSYGYENTGIYPGSITEWLAKGGADVKPKK
The following text describes a protein:
Function:
Important as a means of generating NADPH for biosynthetic reactions.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGTGVFADVLDGEVYKYYADGEWRASASGKTVAIVNPTTRQTQYRVQACTQEEVNKVMDAAKVAQKSWARTPLWKRAELLHKAAAILKEHKTPIAECLVKEIAKPAKDAVSEVVRSGDLVSYTAEEGVRILGEGKLLVSDSFPGNERNKYCLSSKVPLGVVLAIPPFNYPVNLAVSKIGPALIAGNSLVLKPPTQGAVAALHMVHCFHLAGFPKGLISCVTGKGSEIGDFLTMHPGVNCISFTGGDTGIAISKKAGMVPLQMELGGKDACIVLEDADLDLVAANIVKGGFSYSGQRCTAVKVVLIMEAVADSVVEKVNAKLAKLKVGPPEDDCDITPVVTESSANFIEGLVMDAKEKGATFCQEYRREGNLIWPLLLDHVRPDMRIAWEEPFGPVLPVIRINSVEEGIHHCNASNFGLQGCVFTRDINKAIMISDAMESGTVQINSAPARGPDHFPFQGLKDSGIGSQGITNSINMMTKVKSTVINLPSPSYTMG
The following text describes a protein:
Function:
Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells. May also be involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization through the recruitment of GRB2.
Subcellular Localization:
Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.
Sequence:
MAQPELLWAAAGLMLLGVAVSACVRCQLYATKRGKDGSQGSRLERPQRFEVIRSCSAVTRRPERIKEPEHLARKAPEELSTSCHVGFESSAEPRYQNFLTEDCLHEDAAYVEPVPLDYYSHNRFFSPPNDEDSHSYQNVIIGDPCSSELDDAEDYENSTAIEVWKVQQAKAMLYAESQDEEPDYVNTDPTIDAVVLSK
The following text describes a protein:
Function:
Involved in gross chromosomal rearrangements (GCRs) and telomere healing.
Sequence:
MIPNHILILGSPNSGKLRIANLISKNEEIPNLEDVESHSGLIVKTSLRTKYYFLKLNILIDEYSESKEATDEKKLSELHKWYQEFKSEEFGELREVLDGLMFTINMKTDSISFIGDALEIIEQIKISLGDEENLHDWGGFIAVVGSCPENQIVEDDLILEIEDMVLSQGLEFINLSTEGENEYKEKQGKDRIVELIESHDWTNLEMLKVDSKQYETNKLAKMESMKQKLINEKEELDLDDIFSKLNLARDHAQSLTQDERDKYANKVIEEIIDFL
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MDLPVDSTSGVLSMTQTVGSNFKGSRSNQSALDSLTNNTASLGRSNTTGSLHADIASTQDNPIEFILPTLQLINSSEQTGSDIKGSQYVHDYSESTINANILAITGGIPPLIQSRKVSTTNRNPAKRWQWQPFTHSARLDNFKLYHWSSDPKATVCIVIDSMFASQSVKASIMTYTDEEYESYLQVHVLLITRISDPSWTREETDQLFLLCKEFELRFFVIADRFETNTVRTIEDMKDRYYSVSRTLVLVRYGAQDAQAKLMSAKFGYDKPREVERKRLLAKLLSRTSAQIQEEEIIMLELKRRALNEDRWVKDREAILRSLMNNELPNEQIASTPHSVSSVEIKKKRRSVRGDETPISSTADAFKNSRKDRTIDDSLLRKEKIPAGVHLRSSRFPPIKASLQAKVSTMMIECGAGILPSMPTTAVCAKFEAIRQTIVALIEGKKMLDRLEHEYKVTLIRRTTLKDGIEGGVKPAPSITAVTSAVNHGTALHATLAAQTPVSTQKRPSMTPPSQLRDTKRPRH
The following text describes a protein:
Function:
Light-emitting reaction in luminous bacteria.
Sequence:
MKFGNICFSYQPPGETHKQVMDRFVRLGIASEEVGFDTYWTLEHHFTEFGLTGNLFVAAANLLGRTKTLNVGTMGVVIPTAHPVRQLEDVLLLDQMSKGRFNFGTVRGLYHKDFRVFGVDMEESRAITQNFYQMIMESLQTGTISSDSDYIQFPKVDVYPKVYSKNVPTCMTAESASTTEWLAIQGLPMVLSWIIGTNEKKAQMELYNEIATEYGHDISKIDHCMTYICSVDDDAQKAQDVCREFLKNWYDSYVNATNIFNDSNQTRGYDYHKGQWRDFVLQGHTNTNRRVDYSNGINPVGTPEQCIEIIQRDIDATGITNITCGFEANGTEDEIIASMRRFMTQVAPFLKEPK
The following text describes a protein:
Function:
May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.
Subcellular Localization:
Nucleus.
Sequence:
MMLRVEELVTGTKNDGKETRNFLPEDFKNGDYESAKTLEKQEDRKTLRTHHFRALESQTEETEKQREAELKKKKLEQRSKLESLEDLEKIIQLKKRKKCKKVKVPVLKDPEPEKIPEAVDIPLFLKAALENRLPVIEKFLSDQKTPDVCDEYKRTALHRACSEGHLAIVEKLIEAGAQIEFKDMLESTGLHWASRGGNLDVLKFLLNKGAKINTRDKLLSTPLHVAVRTGRYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLILHGANLTIKNCEGKTPMDLVLQWQNGTKEIFSSLKEESFHPFPQPCSTGSWTSVNIFRRLRLPHRVDDAKSSLPCFWNKGERI
The following text describes a protein:
Function:
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of elsinochrome C, a perelyenequinone phytotoxin structurally similar to cercosporin. The first step of elsinochrome C biosynthesis is performed by the polyketide synthase elcA which catalyzes the formation of nor-toralactone. The starter unit acyltransferase (SAT) domain of elcA initiates polyketide extension by the selective utilization of acetyl-CoA, which is elongated to the heptaketide in the beta-ketoacyl synthase (KS) domain by successive condensations with six malonyl units introduced by the malonyl acyltransferase (MAT) domain (By similarity). The product template (PT) domain catalyzes C4-C9 and C2-C11 aldol cyclizations and dehydrations to a trihydroxynaphthalene, which is thought to be delivered to the thioesterase (TE) domain for product release (By similarity). The bifunctional enzyme elcB then methylates nor-toralactone to toralactone before conducting an unusual oxidative aromatic ring opening. The next step in perylenequinone biosynthesis is an O-methylation at the nascent OH-6 of the elcB product performed by the O-methyltransferase elcD. The oxidative coupling of the two monomeric naphthol units in perylenequinone biosynthesis is catalyzed by the FAD-dependent monooxygenase elcE and the multicopper oxidase elcG. ElcG might catalyze the first intermolecular coupling in a regio- and stereo-selective manner via a phenol radical coupling mechanism and the elcE could forge the second C-C bond intramolecularly via a hydride transfer mechanism. The fasciclin domain-containing protein elcF might also play a role duting this step (Probable). The last piece of the puzzle in the biosynthesis of elsinochrome C is the additional annulation by enolate coupling to afford the dihydrobenzo(ghi)perylenequinone system, catalyzed by the FAD-dependent monooxygenase elcH.
Sequence:
MFTLRSLAILAVFAATALASKQSSNDRELVVAIYGGGLASATLAQALKGSSNLNVQYFDPALDLTPTSFRLFGFDPKVHDALALVNEEAGGAIERSGWYPEEPSVVVVGQGSDADTVVLDWAQLKNTTHHPQVTVVDPKPFLQQMLNGTDESRLHPNKTLVSITRKDLSAKYPLELKFQDGSIQHADVLIGDDGPFGQMRSEVLGAKHPANAPVFMNFLSAVAHVAPDDAEKLLGQKYGNRDLGRRFERVGMGSWFLNAYLEGFSTCLGSFYTEEAYDLSQFTRTTSVKELTARFSNLNEADNSQKILSGYSGLRLIPEIEHSPAPTYINGLVAMQGNAAHFMTNFQQLGPSQQIEDAMILGTLLRSAHSRADVEAALYAYDTVRRPRSQWVSEHGKRLGWLWTGMVEDVGIDAKKLKKAMLQWKQDSEAFDLKAHKNEAVKIMKQTIKERSGSEKIITQEEKIKAGFQGLWEAMREKSGEQVEL
The following text describes a protein:
Function:
Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).
Subcellular Localization:
Nucleus.
Sequence:
MADSPFPDLNVSDFGFLNDITTRQMCSYCGKSRMYYCYTCFKPLATLQDKMPDVQLPFYVDIIKHPGEICGKSTSVHAAILSPRHVNIHIYPNIPQYLVNNVVAGKEDENQFGGSTVLLYPCKESFPLKEFVATRFNNMQQKKIDVTHGVLQRVVFIDSTWFQAYKILTDHRLQNIPRIELDAYETKFWRYQLDKPSTYLSTIEAIYYCVKEYSACIKQLSHDSGCESHVNTRLFSKELITTSDVSTKTGLTITKSNEDCVGYVNPESNVKPLINLNEPNYDDLLFFFCFFYCKIRKNASESGRILKSYSQQRKKKQ
The following text describes a protein:
Function:
Hydrolyzes the short-chain alpha-galactosaccharides raffinose, melibiose and stachyose.
Sequence:
MEIFGKTFREGRFVLKEKNFTVEFAVEKIHLGWKISGRVKGSPGRLEVLRTKAPEKVLVNNWQSWGPCRVVDAFSFKPPEIDPNWRYTASVVPDVLERNLQSDYFVAEEGKVYGFLSSKIAHPFFAVEDGELVAYLEYFDVEFDDFVPLEPLVVLEDPNTPLLLEKYAELVGMENNARVPKHTPTGWCSWYHYFLDLTWEETLKNLKLAKNFPFEVFQIDDAYEKDIGDWLVTRGDFPSVEEMAKVIAENGFIPGIWTAPFSVSETSDVFNEHPDWVVKENGEPKMAYRNWNKKIYALDLSKDEVLNWLFDLFSSLRKMGYRYFKIDFLFAGAVPGERKKNITPIQAFRKGIETIRKAVGEDSFILGCGSPLLPAVGCVDGMRIGPDTAPFWGEHIEDNGAPAARWALRNAITRYFMHDRFWLNDPDCLILREEKTDLTQKEKELYSYTCGVLDNMIIESDDLSLVRDHGKKVLKETLELLGGRPRVQNIMSEDLRYEIVSSGTLSGNVKIVVDLNSREYHLEKEGKSSLKKRVVKREDGRNFYFYEEGERE