lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MPSIGFCKTSPTKNEKNKEDTQKQFPVPVSDAQVNEWERQVTSLNMSIRALIENARLFRDSWRCVVCTGPSLIAAWIALYRQIPPEKSLAASVGTLVEWNKALESQRREVLLLLQPFDYSILAPCKEVKHYMKKADELVQKRTRKKAEFDKLQKDLLSLYELHEPESQRHKLKSFRSSLQRVNKELDELNRVLAKNIPAIISKSRTLFQHLLKRFYKTHFQIARKMFIAVRPWDCFQDDILQTWNEEFGEIREAMERLQLLSGTLSRTTSLSSLPRIDTSVSSLSQNNSPLYNSAISESSSANSSFLWLSPNVPDTRYKDKTLRTVKDFASSPVKSLSSTSLSVKSVNPPTFSFQQSDYSVLPEESLNNVQLVPEDWSFLASGNANAVFEYTGKDPYFRGKVLRVRRRGQTLLSQDVHSYFYSTIRPLFQGFEKHLLDITLLPTTREFLEALQKTSNMLLNLNDTSGIIMRDLNEGLEMKPKWLSQSPTAPTDWVVCRTCAICRMRGKPVGFCPLRLDPDNWERFSSALRNVVSGNVARRIYNSGILKRLRSLQKQFETSNISLAMTLRDVTLYIGVTGITIIDLDPKDGNVKQARWEKDEKDLIQGGWYYGRGMKASDQPCRSV
The following text describes a protein:
Function:
Mediates and enhances the nuclear envelope docking of RANGAP proteins mediated by WIT1 and WIT2 in the undifferentiated cells of root tips. As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes.
Subcellular Localization:
Nucleus envelope. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Note=Targeted to the nuclear envelope (NE) during interphase. Associated to the cell plate during cytokinesis in root tips.
Domain:
The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to the SUN proteins.
Sequence:
MDLESESSALESVDDNVLIQQSASNVCDDGRSLDNGSCSDESVKLLSTSNSVELGKPMSFDSPGDGGGAYSPVLKGQGLRKWRRIRRDLVKDTSANMENSKALKRGLSGVAHSHGKQMQFQSPEVEQESQGSVGSVNMLKSSGDGFDILGSSGYDSRFVAGVGFSAGMDLEIDDDRSSKSSTVARAPKVIRYEKPMISSGQGGNIRVENSKKHRGESVDFEKENSYSSLESDSRKQSGRMMDYNGENGETSMRKDDAGGEGGESINTDNRYSDEMDPLTEAINGFLALQDALEKEVQQFQEIGNEPMPQHHEQVSEANSPHPEIVTLVNNVEQLENMLEETRSMLEVKESHIRDLESTTNQSKHSWGGTEIVVEDIFRQKIEAEIEYLIYSRSIDNLNSQMKLIDEQESLAEEQTHETLNKLGRVQTKAANFTNRAQDLQNDCIEITGTIKKRACKITSYVLIQLVLLSTVVLLLLSQLLPEPDTVVPT
The following text describes a protein:
Function:
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Sequence:
MLIPEDDKLDDEKMINIAKKLWFIGFFFLPWVWLINILYFIPYRNSLNDKVKWYLKFSLIGFLGYSTIFMGWMGIYLVNRNKWGAFGDDISITIPFG
The following text describes a protein:
Function:
Translational activator of cytochrome b. The cytochrome b (coB) leader RNA may represent the target sequence for CBS1 and/ or CBS2.
Miscellaneous:
MISCELLANEOUS: Present with 2140 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MSSSIPRVYSLGNSAMTYLLALRIAQLPSQPKVPSVVLLLNDQKKLNRFLNNDSKIIVKSSNNNKETYHRQFMASCVPPILSNGEIAPIENLIVSDPSSKFITAQLSKYNKSLRPETNILFLNPSLNLLEHLHRYRWRFDEARPNLFMGFTTPVDVGTIHQEFQLSLKVKGRIQFHIAKIDGFPRMSSTGKSASLSLRGDRQKNEKENNAFYKLFREISRLRSGIGSDLVSFDLHVHGFQDLFFTELEKLILESCTEPLLAVYDCVYKKELLKIPGAQDIIKKLISEQLSIIDRSYPSLNTNPNYSVIFDKERIFSLVMRDLEVNGHKRAKLAQSLNQLNQTNINELNGFFVSLGKYKKCNCKWNDILLTLIKGKQFITKQKALDYHYL
The following text describes a protein:
Function:
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
Domain:
The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.
Sequence:
MRIDKITLTNFLSHEHSEIQFMGEINVIVGQNGAGKSSIIDGIVFSLFRTHSRGNNDNLIRKGSNRGSVTLYLSNEKDKIEIIRDIRSTTEDRLIRNQFPIARSATVVSNEIEKILGIDKDIALSTIIVRQGELDKILENFQEIMGKILKLELIEKLIDSRGPIVEFRKNLENKLRELDRIEQDYNNFKKTVEEKRARVLELKKDKEKLEDEIKNLEKRIKDIKDQFDEYEKKRNQYLKLTTTLKIKEGELNELNRSIEELRKQTENMDQLEKEINELENLRNIKLKFEKYEVLAKSHTEMSANVINLEKEIEEYEKAIRRKEELEPKYLKYKELERKLEELQPKYQQYLKLKSDLDSKLNLKERLEKDASELSNDIDKVNSLEQKVEETRKKQLNLRAQLAKVESLISEKNEIINNISQVEGETCPVCGRPLDEEHKQKIIKEAKSYILQLELNKNELEEELKKITNELNKIEREYRRLSNNKASYDNVMRQLKKLNEEIENLHSEIESLKNIDEEIKKINEEVKELKLYYEEFMRLSKYTKEELDKKRVKLDEMKKKKEEIEKEMRGLESELKGLDRKALESKILDLENKRVKLDEMKKKKGILEDYIRQVKLLQEEVKNLREEVNIIQFDENRYNELKTSLDAYNLSLKEKENRKSRIEGELESLEKDIEEISNRIANYELQLKDREKIINAINKLEKIRSALGERKLQSYIIMTTKQLIENNLNDIISKFDLSIKNVEMEIMPKTGRGRSSSGDILVYTNSGDTLPIVSLSGGERIALSIALRLAIAKALMSNTNFFILDEPTIHLDDQRKAYLIEIIRAAKESVPQIIVVTHDEEVVQAADYVIRVEKRGNKSFVREET
The following text describes a protein:
Function:
Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage (By similarity); Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MPVAVGPYGQSQPNCFDRVKMGFMMGFAVGMAAGALFGTFSCLRFGMRGRELMGGVGKTMMQSGGTFGTFMAIGMGIRC
The following text describes a protein:
Function:
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Sequence:
MEGSIHDIVERLGSEEDAVRKMAVFKLQGSIGDPSFADIFIAEGGLTKLRELTLHATGNTLAYSLTSFARLLEVDKGWDLVDQELVERIVQLIVTQPLVNILRGAMSILVSIVSHPYTGGRPSQTDSFGFRALKPALAIYPQFLEMLVNRLSSADHALCANALQLINSLMRDSIANDSELEWPRFIQKLQDLGVIRAVYALMQGTTLQDHAHPLIEFQSLTKVLLRRWRDIPLDLEKPEHRRALKGIHLASDQEKGIDEKVGSDAELRRSRKHNSEKWRRLGFESENPIAQFEEMGFLGMMDLADYVRNHRSEFRKMLLEQSAKPGQKRCPIARASLAVTSILYEHFEIEKSEIEDSRSYLVLESRANLDRLFKPLLLHWTRLHVAALQAFVRLWKTTNADVDDFAKIAELVRILVESVVGGAPRTKEVQDVEDEIVNFEYRRLRDLQMELLELTYEDAWRQHLLQVREELHHEALQFVKEQRIRCLLQGCWFPVEATTHTDSSSVENVSYRYVQLSHNRKFLHYGDFETLGNGRIDLDSLPGKVDLSAVSSVASNISASADASSSSTLKIAPLSVPSTKITIHGYIECFSSTRGPSKGHNHARSISKSKEGVLLTLRPQTPSIASEWLDGLLMLLNQRPITADTNKLIKVVSDYGLKIRLFNVRFEDATFPGEVPKVPSRDGLDDDYYYDLFGAS
The following text describes a protein:
Function:
Probable transcription factor involved in the regulation of flowering time under long day (LD) conditions. Plays a major role as repressor of flowering. Controls flowering time by negatively regulating the expression of EHD1 and HD3A.
Subcellular Localization:
Nucleus.
Sequence:
MSMGPAAGEGCGLCGADGGGCCSRHRHDDDGFPFVFPPSACQGIGAPAPPVHEFQFFGNDGGGDDGESVAWLFDDYPPPSPVAAAAGMHHRQPPYDGVVAPPSLFRRNTGAGGLTFDVSLGERPDLDAGLGLGGGGGRHAEAAASATIMSYCGSTFTDAASSMPKEMVAAMADDGESLNPNTVVGAMVEREAKLMRYKEKRKKRCYEKQIRYASRKAYAEMRPRVRGRFAKEPDQEAVAPPSTYVDPSRLELGQWFR
The following text describes a protein:
Function:
Required for zonula adherens biogenesis and maintenance.
Subcellular Localization:
Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MAAPLRRDTLPDNGSYGVCRDGRVFFIDDEARATTWLHPRTGQPVNSGHMIRSDLPSGWEEGFTKEGASFFIDHNQRTTTFIHPVTGQISTENSDFRLQDQPGGRMLKQPSSTISEASTTVTTSTVDSTSGSKGSRSSGRVHSFGKRDHAIKRNPSVPVVVRGWLYKQDSSGMRLWKRKWFVLADFCLFYYKDSREESVLGSIPLPSYTIAPVGPEDHISRKYAFKAEHTGMRTYYFSADTQEDMNGWVRAMNQAALMQTHTVKRDECGHPDHVNVSEKLKKQAVPQTNHINSYVIPKPEVIQSDGLPEDKREGFVGEVEIQVTPREMEQARGKSPASRVVEVEVLAPGSTPPSRVASRAPSRAVSTPPVVQRNGTPIEQNGMPGCQRGATPSAQTPVQVQRRSTLEQVENWVKVQKEERHGLVSTESTVPRRTPPIHPKYGTMDKYQSLPKTSRQSPPAPHHQLPSEYKYSHDRLNHFQKIHGHTKRPTTHDNTVWQLFEWQQRQQFRHGSPSAPVYTPAPDYSTAVSSTRNNSDVSRSVSVPPTLADIPPPGPPGARLMSPRRPHTPAERVTVRPLEDRPIVEVPPSNSPHRLRSYKSATIERRSMPPSAYITHTVSAPSLHGKTADDTYMHLKKDLEYLDLKVSGTEALKGRPAKPVKVAESDVDVTLSRLCEQDKILQELEFRLSGLKDDKDKLESVLDVSHQQMEQYKDQPSHTDKIAYQQRLLQEDLVHIRADISRVSTEMERAWDDYSRMEQSVEQLRDVLQTQMTLCTSPQEKNQLKRELWRIEDVMTGLSSTKETFKITVDSVKNPERKLVPSVIESTVPSRCMTPSAAEVRSPQRSLTSSPLPLPLDNEDLRNRHPVPNWEEDDAPPRPPLPLLYDEDTPPVVPPLPKETSVIRHTSVRGLKRQSDERKRDRESSYSNGDYRLELRSYLSEPELPVSAHGADHVDPGYLTLQRRGLSGSSSRINQYGVASCSLRRDLELSTMERPKSALERLCSGEPQLEQQSQPQRVRMSVEEQLERMKRHQRALVRERKRNLSQGERHHSRASTRPVNSDPGSALFVEPYRPASDEWLTVRARPVMELELEPLDFEFDITRELSTPQKVWIPQRLIDDESDEDLSPEEKETRSRTVAKIKTLLSKSSMRSSEQMDFSDLDLALQQQERIMSVPRALATEASIKRRQVTAKAMSEG
The following text describes a protein:
Function:
Probably involved in the degradation of cholesterol. In vitro, catalyzes the introduction of a 9alpha-hydroxyl moiety into the ring B of 3-ketosteroid substrates such as 1,4-androstadiene-3,17-dione (ADD), 4-androstene-3,17-dione (AD), 4-androstene-17beta-ol-3-one (testosterone), 4-pregnene-3,20-dione (progesterone), 19-nor-4-androstene-3,17-dione (nordion), 1-(5alpha)-androstene-3,17-dione, 5alpha-androstane-3,17-dione and 5beta-androstane-3,17-dione. KSH has the highest activity with 3-keto-Delta4 steroid substrates.
Sequence:
MTTVEVPHGSRSVILTVSAVVEETADTRSIVFAVPDELRDKFAYRPGQFLTLRIPSDRTGSVARCYSLASSPFTDDAPKVTVKRTSDGYGSNWLCDNIATGQTLEVLPPAGVFTPKSLDHDFLLFGAGSGITPVISILKSALTQGGGKVVLVYANRDEKSVIFAEELRALAEKYPTRLTVVHWLESVQGLPTADQLAAIAAPYESYEAFMCGPGPFMDTVHQALNTVGMPRARVHAEVFNSLSGDPFADQAPVEVSDEDAADAATVEVELDGEVHKLSWPRKQTLVDIMLAKGIDVPYSCQEGECGSCACTVLEGKVEMENCDVLDPEDIEAGYILGCQARPVTDHLKIEF
The following text describes a protein:
Function:
Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2. Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAATANLDSAQSPGPSWPTAYGAPLREDWNGYAPGGAAAANAVAHGLNGGSPAAAMGYSSPAEYHAHHHPHHHPHHPAASPSCASGLLQTLNLGPPGPAATAAAEQLSPSGQRRNLCEWMRKPAQQSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKERKIKKKQQQQQQQQQQQPPQPPPQPSQPQPGALRSVPEPLSPVTSLQGSVPGSVPGVLGPAGGVLNSTVTQ
The following text describes a protein:
Function:
Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
Subcellular Localization:
Nucleus.
Sequence:
MDRVTKPQKKMLITLLRETKYMEGKKEKEWYWEKIQAALNTIGPKKTIIQWKKCWRDMRLTTRKKLAELKRCQLSGGSPPPGIELNQEDNDIIDIVGTEYFYEEMNGELKAENFLTGLDYAPEHLCDAILTAAVGHHQHNMQHQKDPQSHAGQQQQQDHHTNDGETNDAPGSSNGGSYQGHPVSQLQAHNGSGGGGEHSGGGQSHSGMLQHPAFHGGLHPHLLRRQHGSGSLSRESPFEEKLLQFMQDAFPKKSKKRKNRDPDKLFLLSLYEEIKRVPEEIRLDVKSELMQILKKYQKKSPVKAEKPAPSSTSTSSKLSSSSSGSSTVTTHLSHSMYQLQKKYEKGEREPSPQSQVERVASAGAVAVPIHTSQQLPLFQLQKKYEENSVEKVHQQQQQQQSEQRKHVEAAQALHAAHQQPPPPPPNEHLHHPQMAHNIMFPLGQLRNEQPTAQQHQHGHNPHQQQQQHPHQQQQQGQQHHPPTIFGSTASERPPMSYENVGXVLSRLWEATCGAPRPATVSPTTADAHSC
The following text describes a protein:
Function:
Could be implicated in synthesis of very long chain fatty acids.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
METVQSIITEWTDPKSWEKLVQHSFKDSNWKELIDPVNYKFNFGVTPFSQFQIIPIVLVIYLVTIFSIKFLMKNRKPFSLKFISILHNAILCIWSLIMCVGVLYEIIKRVSNEGPLFTVCEDPNGGFDKGVTYYWSYIFYISKFYELLDTVIIVLKKKPLIFLHVYHHCKTVWWKKYITMIQILQFVCLGIAGVLHVYTINTIGCFTHYPAFAAAYSINFSFLFLFSKFFVKSYTPKNSNSNTNIKSKKID
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSLEIDAKAVSALLLGQGCANNLKTLLKNHETGSVSTEPLINSILDSFSFALSSQNIPRHVSQRSSKKKMCGIQGMEDSPTPAHIDGFIWRKYGQKTIKTSPHQRWYYRCAYAKDQNCDATKRVQKIQDNPPVYRNTYVGQHACEAPAYAVNNGGTYGSKMIKFDYVIPESVMPQPLSIDSQEITMEDKDTDDHILNYINEHLMEDEAYDVFPDVLGERCCFGLEPFPGLNINKS
The following text describes a protein:
Function:
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Subcellular Localization:
Cytoplasm.
Sequence:
MNKNNNKGSVKKNNNSKKKTSTNINNVNNLSSIKNIKNEQNVKNGDVNDEIATTTSSNHVNMVLNGNDEGIKDVKVVNNLNIDNKREDNNVRINVQGEETLNNDSKNKEAENKSNIKNNKSNQSNQSNKKTKNNNNNKNNNNNNNNNNNNNNNNNKNSTSNKKNSKNKKKVDKLDLILNEFKNDIKNEKGENNQNDNKLLNGAIETNNNNNNNNNNSGNNRIHFDKEEIKEIKKKIILKEHVLEEQDNSSIRLLKNWPQLEKTYQTNPPCIPIDMIYGKDGKYPVGEILEYNNYNLSGQSLVEKKEREKLSIDYYEDLRKAAECHRQVRKHMQAFIKPGKKMIDIAQETERKTKELILAEKLKCGWGFPTGCSLNHCAAHYTPNYGDETVLKYDDVCKLDFGVHVNGYIIDCAFTIAFNEKYDNLIKATQDGTNTGIKEAGIDARMCDIGEAIQEAIESYEIELNQKIYPIKAISNLRGHSINKYIIHGGKCVPIVRQKEKNEIMEEGELFAIETFASTGKGYVNHENECSHYMRNPEKQFVPIRLNSAKTLLKVINDNFDTLPFCNRWLDDLGQTRHFMALKTLIDLNIVEPYPPLCDIKNSFTSQMEHTILLRPTCKEVLSRGPDF
The following text describes a protein:
Function:
Required for formation of the rec12-mediated double-strand breaks (DSBs) that initiate meiotic recombination.
Sequence:
MRKEYLVSHIEENAHQADIYSLNVVAGNLWSASGDSKIKKWSIGDAEHSLVEEIDTPHKLGVHHLATSLDENVVVSCGFGQDVYVWNPETNEFRDLGNNAQHPSECWSSCISPDGQTIAFTSVDGRIAVWDNPSDCKISELDTKGKFGLCIDYSPNGRFIVSGHQTGQLFLISTETGRLFHVLSGHTSPVRSVAFSPGSTLLAAAGDSKMITIYDVLSGDQVGQLRGHAAWIFAVAFNPVGDLLLSADVEGKIKIWDIDTMECISTQSETDGAIWAVAWYKNGFIVAGADKSIRWYRAAATE
The following text describes a protein:
Function:
Required for efficient biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MATNDQKIDNKSTVSNMLENPMFQTFSKKETEKPSLSEYMEQLTSEFGEELDNLRQKEIFDHNKLQLLIESLRAGHKIYE
The following text describes a protein:
Function:
Plays an essential role in competence development.
Subcellular Localization:
Cytoplasm.
Sequence:
MECNLAQAKQWVSALDQRRFERALQGSGDAFQHVLAIVPLLLHLNHPQLPGYVIHAPSGIASFLASDYQKKWLTNEYGIHYADHKPSTLKSAVNFHEVFPPILGVYVMGSFGSISQTSSSDLDTWICVRDGLSLDEYTLLTQKAKRISEWAMQFNVEINFYLMDQQRFRNEHYADPLTIENSGSAQYMLLLDEFYRSAVRLAGKPLLWLHLWVENEKDYEKEVARLITEGEIDPNDWVDFGGLGQFSANEYFGASLWHLYKGIDSPYKSVLKILLLEAYSKEYPNTCLIARTFKRDLLAGNTNPDHHFDPYIAILAKVTQYLTALSEFKRLDFVHRCFYVKATEDFARYQANNWRIRYMEILAQEWGWSAETVKHLNKRPFWKIKAVKENHDNIMKFLMLSYRNLVEFARKHHIHSSVVPQDINILSRKLYTAFEELPGKVSLLNTQISHNLSEAHLTFVEVRGNKHFKDGWYLINQPIHHIMFSKERVIEYGESLNKLVSWAYFNHLLTEKTELSIFSKNVTLSTLQRFVTNLRQSFPSTIAKQPKNSDLLNQCEIRSLFIAINLTTDPTSKVEEVLTGISSRDLFSFGSLEQSLVGSIDFTYRNVWNEIRTLHFEGQNAILLALKVLSNKIYRGVNRPDSIQVYCYSERYRQDLRQLVMGLVNRCVSIQVGDIQQPCQTSRLRVAGKNWQLFFEDRGISLQEIGNESVCNEAESAVDFDEVLQTPIEDGETNQESRRYPPEMDAFASEGFLQFFFEDNSDHSFNVYILDESNHLEIYRHCDGEKDEKVREINQLYQNAKQEGDKNPYNIVQHNFNYPQFYQLQNGKNGISIVPFKFRQMNK
The following text describes a protein:
Function:
Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
Subcellular Localization:
Nucleus membrane; Multi-pass membrane protein. Nucleus, nuclear pore complex.
Sequence:
MTSKPHWFMQEVFLFRTIASQLWAVLLVPAGVYGLLLTTQVDLLHPWRWIVGCLFEALSPYNWGYLLLLWGVVVVAGTSHARHLTVSPKIPQTRLARLVQLLSPSSLMHAGMHVVMAMVMSYCAAALIGPQFSSLSLPCQGSDQNMGGTVGPVHCLNEKSVFVVFSGAFLGLCYSVQYFLHSRHRLQFPVIQQAKFFRVRTLLPRLVVDSASRVVRLLPGYYLGYYLLGHGVKTWMCALLRLKPSPVDIGSLHGLLDVGLLWQTAVGGTFMFCLLDTSWLMLHIFHAQVFKFEVASSLADQTDRYLSDAVQCQDVPLVQYLGFLDLSLLAQFSPQRRRHIFSLSQPGGHPYVWKTVSTSSLAVLDSLTNRLAACRQNIGVTGQRLSPDPTRVQGSQKVGVGGGQAPGKLEKVTLGLRRTPVLAYFLQQLPEAASAELFQDAQLLVWVLEGLSHLVAASYTEDTYGVVQKSLPDILTALIGLHEALDRHFKMPLAGSRPSQHAWLSCQRDVSSQNMRFSLLPAATTALYHIVNVFGKHVESIPLSTEHKQKLRLFLPQRDAAGIPRS
The following text describes a protein:
Function:
This protein binds to 23S rRNA in the presence of protein L20.
Sequence:
MFAVIKTGGRQYRVAPDDVLEVGKIEGEVGSIVQLNEVLVVGGDTPILGLPTVAGASVAVEVLDHKRGPKVIAFKKRRRKNSRRKRGYRDEITVLRVSEILTDNAKPTKGPRPKKEKVAKEATKEDAAA
The following text describes a protein:
Function:
Protein required for cold tolerance. Plays a role in the regulation of phosphate uptake.
Sequence:
MKTIIISDFDETITRVDTICTIAKLPYLLNPRLKPEWGHFTKTYMDGYHKYKYNGTRSLPLLSSGVPTIISQSNFNKLFADELKYQNHNRVVELNSVNEITKQQIFKSISLDQMKTFARDQNHEDCLLRDGFKTFCSSVVKNFESDFYVLSINWSKEFIHEVIGDRRLKNSHIFCNDLKKVSDKCSQSYNGEFDCRLLTGSDKVKILGEILDKIDSGCNKEGNSCSYWYIGDSETDLLSILHPSTNGVLLINPQENPSKFIKITEKIIGIPKDKISSFEADNGPAWLQFCEKEGGKGAYLVKSWDSLKDLIMQVTKM
The following text describes a protein:
Function:
Probable component of a branched-chain amino-acid transport system.
Sequence:
MKCSCELGDTTILILEPEQYVGALKMDARRSTILQTENLTKRFGGLTALNRVSIKVERGSLTMIMGPNGSGKTTLINVCSGILKPDEGRVLFDGEDITGAPPHEIYKLGFIRTFQIPMPFLKLNVLENVLVAMKNSGESPLKAPLRPLWMKEEEENVKRAMEILGRVGLSDSWDKESFKLGGGQLKMLEVARALAAGAKLIALDEPIGGVDPAYANEILGYLSDLRKNLGITLLLIEHRIDLALPFADYVYVMDRGVVISQGTPEEVSNDPKVLEVYLG
The following text describes a protein:
Function:
Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
Sequence:
MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEELRKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHELANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAAVAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQPNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESYALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG
The following text describes a protein:
Function:
Required for autophagy.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAASAAAGAVSQVQEQTWETKIPVHLSLAPDNISSPAAVRPIYLMAPRQGYLHALAAQAWPHLQLMAPRQGYLHALAAQAWPHLQHVLPSVPGRSTPRPWFDCGGVPLKWYLPCGVLYDLLSEGGRLPWRLTVHYTHPPDSLVGWETGANAMAQFMNCLKESSYVCRGPDGAGAVMRTGSSQQEALWAAVGAGDLQAYRAALGALKVAPQPRQGHVPNIPVRLLLRRPPPSSAPTAATAATAAGASTSSSFLAASSTAAGQAPQPPQPQPRPGNGGGAAAGGGGAAAAAGGLGASMMGGPGPVGPGGLWETCVTATSRPVPALQGGGAVAWGAAAGGGDGGGGGAGEGGGTPTTLGQLLQLVLPHIFPPPPPPPPSAPSRAAASAAASAAASAPAAEAASTAAVEGSSEAASAAVEGSREALGQGKAGVEPAGDMSAGAGAGAAVGADKAGATAVETAEGEAAGGGGGGGGPPGNAAATSSEAEAEAAAGAASGSEPDPGSAALEPAAAAAITAAATGSEATAATAAVAVAAAAAAASTLPASGAAASGPTGAASGAAPPPAPPAAALAASAAGQAAGSSDSCLAAQSQLPPPSRLRRRRRPEGWPARFRVLVGGVCPPLEAPLGWLHAAMHSPDLFLYVVVRLDEEGGQGQAEEEWEEEEWEEEEAGEAGLG
The following text describes a protein:
Function:
Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Miscellaneous:
MISCELLANEOUS: Present with 2490 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAHRKLQQEVDRVFKKINEGLEIFNSYYERHESCTNNPSQKDKLESDLKREVKKLQRLREQIKSWQSSPDIKDKDSLLDYRRSVEIAMEKYKAVEKASKEKAYSNISLKKSETLDPQERERRDISEYLSQMIDELERQYDSLQVEIDKLLLLNKKKKTSSTTNDEKKEQYKRFQARYRWHQQQMELALRLLANEELDPQDVKNVQDDINYFVESNQDPDFVEDETIYDGLNLQSNEAIAHEVAQYFASQNAEDNNTSDANESLQDISKLSKKEQRKLEREAKKAAKLAAKNATGAAIPVAGPSSTPSPVIPVADASKETERSPSSSPIHNATKPEEAVKTSIKSPRSSADNLLPSLQKSPSSATPETPTNVHTHIHQTPNGITGATTLKPATLPAKPAGELKWAVAASQAVEKDRKVTSASSTISNTSTKTPTTAAATTTSSNANSRIGSALNTPKLSTSSLSLQPDNTGASSSAATAAAVLAAGAAAVHQNNQAFYRNMSSSHHPLVSLATNPKSEHEVATTVNQNGPENTTKKVMEQKEEESPEERNKLQVPTFGVFDDDFESDRDSETEPEEEEQPSTPKYLSLEQREAKTNEIKKEFVSDFETLLLPSGVQEFIMSSELYNSQIESKITYKRSRDMCEISRLVEVPQGVNPPSPLDAFRSTQQWDVMRCSLRDIIIGSERLKEDSSSIYAKILENFRTLEMFSLFYNYYFAITPLEREIAYKILNERDWKVSKDGTMWFLRQGEVKFFNEICEVGDYKIFKLDDWTVIDKINFRLDYSFLQPPVDTASEVRDVSVDNNNVNDQSNVTLEQQKQEISHGKQLLKQLKQGKISV
The following text describes a protein:
Function:
Formins play an important role in the nucleation of actin and the formation of linear actin filaments.
Domain:
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Sequence:
MNRIFGRKKKDKDSDEKGSTESENDFLSSLPAKANKRYSMAYSSLQPDGNNSTNSKSADKFDDKGKAVDTPEFFVNTINLLPNIEILAQLCSSLQSKPSAWSKSLIDCNGIEALLNVLAFIERNGQKDSDVILQSLAVTCLLSLLNSKYGIEKAIATPNSMIRLITSMDTPKADTRSSVFEILTAICMISEKGYQLILEAMTHFKQVRKERFRFTFLVESMKKVMNSSDKEYLTTCLTLVNGIVNSSEEIDERIQLRTEFTRLGLDEVISVNKNIPYEEAPDLLTQIDVYEDEQRADQEELSERFEDLDIDINDPQVIFNEIYKQAKDRLHHPLLAILQSLLSISSDTEVGMLSWFLIEKLVLQISVNKPMIGDDDGKVSLEDLLASTAPSVALQSEFQKNIEELAKVKDQLKKANFDLNIANQELSSRSHESSVLKSNMFNTVKQKDQEIIKLRGQMKRIDSNFFSPPGGDGDDHINVINTPEESSPHHESPRKQQQQTSKPPLNPKSSKPPISSSQLKEKSKSNLSSSSSDSLSNDFKSQVEVAQQQQPQQQNIESTLTPEPTQIIKEEPIVTTPPPAPPAPPPPPMMGGGPPPPPPPPMMGGGGPPPPPPPPMMGGGPPPPPPMGGKGGPPPPPGGGGFGLFNSNKPPANAPKFTVSKPTTKVKQFQWTKIPNKKLGETIFTNLGTIKTDWLNVGEIENLFFAPEANSQKKLEASDKKSTSSTKPGTVSVIDPKKSQNLAIYLSKFKCPLEEIKTALYTLDEDIFTMESLKALEQYLPTDEDMEAIKDYLKKDGELKMLTKAEHFLLEMDSVSSLAERVKSFYLKILFPDKLKEIKPDLELFTKTIKDIKNSKNFLKVMEVVLIIGNFLNGGTARGDCFGFKLDALLKLADTKTANNKSNLLVYIISELEQKFPDSLKFMDDLSGVQECVKISMNTISADLNLLKKDLDAVNNGIGKMKRSKEESYFFSTMDDFIKDANIEIKIAFDQFQEAEKNFQELAVLFGEESKIPSEEFFVTINRFIVMFDKCYKDFQRDKEAAERAIKRDEAKAKKAQQLKRMNGKIASSTNNKNPLASSSTSVGDGGMVEDIMQSVRDGDAFKQRRRLKGTKENTDDSSSITTISEQSENSNTSSITITTPSGIELDITPSKSGSRREKKTSKSSDKDKEKEKEKEKQCESTESEDINKKDINVAAKALTIVMRSKQTMHSRIDTFNFDA
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Miscellaneous:
MISCELLANEOUS: During the reaction, ATP is used to activate the C2 atom of U34 by adenylation. After this, the persulfide sulfur on the catalytic cysteine is transferred to the C2 atom of the wobble base (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards the activated C2 atom on U34. Subsequently, a transient disulfide bond is formed between the two active site cysteine residues (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MIRNVVVGVSGGVDSAVSAHLLAEQGFKVLGVFMRNWDEADEVGRCSGEADLKDAEWACRQLGVELRQVNYVREYWTAVFSQFLDDYQMGLTPNPDILCNRHIKFDLFHKHALENLGYDAVATGHYARNSLGNYLEGIASNNDARLLIPADTFKDQTFFLAGISRKALQRTMFPLGDFQKSQVKDLAKKIGFQRLAKKKESTGICFVGKRNFKDFIQEYITSKRGPFLDIDSGAVVGHHEGIHQWTVGQRCRLSSFLQPYFVARKEAASNTIYVASGHNHPALLSTHIAVDPPNWLCSKSQQILSDTGSLRCRFRFQHTKPLVDCQLSISPSNTFLVELDAPLRAITPGQYAVFYDDTACLGSARILSANPLKKKNAQTQQAQAANLVS