lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable receptor, TonB-dependent.
Miscellaneous:
MISCELLANEOUS: Present in outer membrane vesicle formulations which are used as vaccines in human.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MAQTTLKPIVLSILLINTPLLAQAHETEQSVDLETVSVVGKSRPRATSGLLHTSTASDKIISGDTLRQKAVNLGDALDGVPGIHASQYGGGASAPVIRGQTGRRIKVLNHHGETGDMADFSPDHAIMVDTALSQQVEILRGPVTLLYSSGNVAGLVDVADGKIPEKMPENGVSGELGLRLSSGNLEKLTSGGINIGLGKNFVLHTEGLYRKSGDYAVPRYRNLKRLPDSHADSQTGSIGLSWVGEKGFIGVAYSDRRDQYGLPAHSHEYDDCHADIIWQKSLINKRYLQLYPHLLTEEDIDYDNPGLSCGFHDDDNAHAHTHSGRPWIDLRNKRYELRAEWKQPFPGFEALRVHLNRNDYRHDEKAGDAVENFFNNQTQNARIELRHQPIGRLKGSWGVQYLQQKSSALSAISEAVKQPMLLDNKVQHYSFFGVEQANWDNFTLEGGVRVEKQKASIQYDKALIDRENYYNHPLPDLGAHRQTARSFALSGNWYFTPQHKLSLTASHQERLPSTQELYAHGKHVATNTFEVGNKHLNKERSNNIELALGYEGDRWQYNLALYRNRFGNYIYAQTLNDGRGPKSIEDDSEMKLVRYNQSGADFYGAEGEIYFKPTPRYRIGVSGDYVRGRLKNLPSLPGREDAYGNRPFIAQDDQNAPRVPAARLGFHLKASLTDRIDANLDYYRVFAQNKLARYETRTPGHHMLNLGANYRRNTRYGEWNWYVKADNLLNQSVYAHSSFLSDTPQMGRSFTGGVNVKF
The following text describes a protein:
Function:
Betaine transporter dependent on Na(+) and Cl(-) ions that functions primarily in the epidermis to clear betaine from the extracellular space. Elicits current in response to betaine but not in response to GABA, L-carnitine, sarcosine, glycine or dimethylglycine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGTSEHVPLPTDEAKAKELEQSQHSEEPDRGQWTGKFDFLMSMVAYAVGLGNVWRFPYLCYKNGGGSFLVVYMIFFCLAAVPIFLMEVTVGQYLQKGAMEMWLMCPLFRGVGIGNVVIAFMCIAYFCVIVAWAMFYMISSIAWVFPWETCNNYWNDATCVTGKENFTELARIKALVASAGGHTQTSVEQFWEKRVLHDTGDISEFGGIQWELFFIMAAAWLIVYFALWKGITQARKFVYFCALFPYVLIFILLIRGLTLEGAGTGIYFYLKPNATRLLDTAVWKDAGTQVFYSYGVGFGALIALGSHNKFNHNCFKDAITMCFINGCTSITAGFAVFSILGYMSHVAQKDISEIVKPGVGLAFLAYPEVASNLPMKQVFAVLFFLMITILGLDSQVCMMEGLFTALEDAFPILRKYKKQSLGIFCLFFFCIGIPMVTHSGSHWLTLFDAYGASGYALLFVVFFEVVGLAYGFGAHNIRKALHEMIGVTLPKGIEYVWKFCAPATSLVLFVFCVVYYHPVKYPDGKDFPFWANAFGWFLSSCSMVVIPGYAIYYLFFTNKHLTLKERVRKGLNLDGSFESPAKKNLVNNAEELKFIESSSQ
The following text describes a protein:
Function:
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters via its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of tbp-1 and TBP-associated factors (TAFs), including taf-2 (By similarity). May regulate RNA polymerase II activity and thereby may control transcription initiation by RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MDFSEASTSGDRVNGFAKPFPPKPREGAPPPAPPLAPGASTSQAPPPLQPPPVIESAEKFYVPGVEEKSKFRILSQQVEISNLNISTRSFNVRTEIVLLPCEKSLYQLDLHIGKCSLLPNEVPGSASKVTLNGVECEYSRRDFWKDLAQEKSISSLEPVLYEKLAENDYELQILIPKEVRKKIKHRKAVRLRVDTVVRDPPRGLQFVDFNEHDCHVFTYHTPHISGAREWTVCLDEPDQLALWELTFELEPHLVPVASGELEEKREVSENGKIRYKFHQTVPTSACNIGWAIGRFKLEPHPESPTIYTFSLPGLEPFVNHTTMYLDKMVEFLEEKLSCRFPYPTLKVVFVDQCTEEIQVYSSLLIVPTAMLYHKKIIDVVQEARQKLIFSIALQFFGCLISPAQWWHWWIPVSIARFLTSLYVETKLGTAEARWQLKRAMDDVCDYEHQWGKIVLSPPEPTKKLPLHVDPRHEYTASPLYVEAMLKKGFLTMRMLQRRIGLEPFMRVLHRVLTVGLDMSEKKTTPAAWRHLLTTTESFFRSVISVTGKEIPSFLSQFVRTGGHAAFAVKFDFNRKRNIVEIEIKQDDTEGNGRTQYTGPLSVVVQEVDGAFTHTIQIDGAVSHAEISCHSKGRKQRKKKVPLLTGEEIEIDLTNMDAESPILWLRIDPDYLLIREITISQPMFHWEYMLRYERDVIAQMEALERIQALPSAHSRSVIVDAVANEKFFYRIRYRAAFVLTFVQNRKSEALTVGTPVLINMFRESFGSKAATNIPRSNNFVVTAQNLQQYFVMQALPQAIARLRRQSGECHEDVQPFLLDLIKFNDNSTNRYSDDFYRAALYNSLASSVFPHDALPCHVELPENLSNDVRVLIKEFTYALNMDTVSPSWGRVVGAAALTGLYQLQKCGYLPLDSQLLWTFSHPNCCVQMRRCAITLIIDRIVNDPHAADTRMLDLSRILELAELEQDPSIRRMIPRLLAQTPPTIFGSENAANTAETAERLWKLCTNSSIDSCIRSGFLDVYYSLYALGAPPALGGPEESVGIHRAYVTVPNAASTFATSQWHNSGYEAARRSPPRRDFGDETMNLMQ
The following text describes a protein:
Function:
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks, nicked Holliday junctions and also intact Holliday junctions with a reduced efficiency. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. Plays a role in DNA repair and in genotoxic stress-induced homologous recombination (HR) in somatic cells. Mediates a subset of meiotic recombination events that are insensitive to crossover interference.
Subcellular Localization:
Nucleus.
Sequence:
MSDFILISDGEDEATPPPSKRARKNRTPTDLNLDTEPSLQKQPPGSASTPFFLDETPLSDDVTVLKSSFGSGTGASSGRENNFFGKRVISLESDSEDSPGPESSKKYEPVYTDSWKKPCRLEFGSSDANSDDDPSWMRRASFQSSLSKDAIEVDSDHEKEDTGVEKMGRKKQTITSKSTSLSADSLPKKKMSKDEKTRAAEEKKLQKEQEKLQKAASKAEDAEHKKLEREKQKWAKEKDKALKCIVAWIDNKVLEGSFGGLLISGLKEKCITYHVTTNPIQRSIVWTMTLPEDIAQSLPLGSKIPYVLLLYEAEDFCNLVAKKELLENVYRVRDEYPSYTMCYLTNKLLSYVNKKERVEYKDPVNGCGWRKPPIDEAIAKLSTHYIGVHSRHCVDEAEVADHVVRLTSSLAHCQVRKKLTRLSVYADGTLMSKNAADKHLIRESIWLKVLVAIPKVQPRYAIAVSKKYPSLKSLLKVYMDPNISVHEKEFLLKDLKVENLVGRDTSVGEACSKRIYRVLMSLDGTIKTDDVENGAASFTLPPSDLI
The following text describes a protein:
Function:
Cytoplasmic form induces gene transcription inhibition; Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen. Nucleus. Secreted.
Sequence:
MQQNLNYVYPPIFLMDRAGQEAAAPAANMVPTWVSLPPPAKQPQRRCRRSCITTVLVFLLFLILCALGLGAYQILRMHGELAQLKQAVDSEHQTPVLQKQVGLLETLAERREIKRIAHLTVLNVTRGSKMLLWEPEKDVSFTDGVSYEDGSLLINETGHYFVYSRVRLRGAHCPSPPEFTHTVSRRNQHSKPRTLLQGHKVGFCLGDRSWSSSSYLGAVLRLRRLDRVFVSVSDPQLVSLDHYSTFFGLYKV
The following text describes a protein:
Function:
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
Sequence:
MGGKTKKHAMRLFDRIAEKYDLLNRILSFGMDTKWRKRVVELILEVNPEKVLDLATGTGDVARLLKRKAPHLEITGLDSSSKMLEIAEKRLKDGEFIVGDAHNLPFYDRSFDAITVAFGFRNFSDRRRVLRECRRVLKRKGRLVILELLPPNTKRFTGKIYSFYLKTWVPFVGGLFSGDFHAYRYLSTSVLNFLTPDQIVEMMKEEGFEVSFEPLFFSVAGIFIGDLIW
The following text describes a protein:
Function:
Voltage-gated, high-affinity calcium channel that functions together with MID1 to mediate calcium entry into cells. Required during conditions of environmental stress.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MASNSHNRGHNEDNAPTDQSIPLQDLSGPLERNPSRTSRVGNRFLSRRSLRRGGSLSNYEKVSEESPVEPPPVARRARPQQAGHGNEDEFHIEDPGTFAQAMSAVGLSFDPTHSTTTSARRRESSSDLINVPLDDFGPQEAEHYLSPTDTYEDTAPLTDHRFLQPISGASQNFSGGQDDRGSTHGNRFPSDSRPESRLGDDLPHLESGLGRRRRGSSSAGDSRARSLSPSATGSALQRAGSMMKSMSQRVVNLSNEPEVVEQAIMREEQHKNARLEEPPSLPSLSGYAHDAPSVGMSDDQLPRTGTSASKAWRMYNNPLRGKALGILGPNNLIRVWLCDILVHPFMEPFILVVIIIQTILLALESAKSVWDHPRSVRWGSNPMDYAYFVIFVIYTLELVAKILVSGFIINPAEYSTLDRSMGLRKAIAEKGKNLLAPQRQFASKQQASSSPEPQQASIIRTFTGGFDQLQPEVIDDPLQPRRVRLAHRAFLRHSFNRLDFVAVVAFWVSFLLSFTGVETHHQLYVFRMLSCLRILRLLALTNGTSVILRSLKKAAPLLVHVAFLIGFFWLLFAIVGIQSFKSSLRRTCRWLGRDNETDFDLNDPYGTLQFCGGYLNVTTGAKEPWLKSDLTPSNGDAKGYICPQGSICVENTNPYGGTVNFDNILHSLELVFVIMSSNTFSDILYYTTDSDYLAAALFFAFGIVILSLWLVNLLVAVITHSFQVIREESKRSAFAVQKLDSLDTENTSTRKTSSFKRFYDRTEWLWIGIIILDLVVQAMRSSTMEEDRANLINVVEVFVTIILLFEIILRFASDWRRFHRSRRNWVDLGLALITCVIQIPAIKHSGRPYDVLTLFQILRVYRVVLAFSVTRNLIMVVFRNATGLLNLIMFVFLITFLASIFATQLFRGQIPAENNGGDEIDINFADIYNSFLGMYQILSSENWTTMLYDATAFTYPFNTAWISAIFIILWFIVANFIVLNMFIAVIQESFDVSEDEKRLQQVRAFLEQKQVTGNSQGNLSLSKILMLGRDSNRYRDPLDHGPAALEMLLKDAVVREFLDEQEAPTESRRRDSAPLETAAAATAETVRPGVFSRWWTAITTSVLRREPNPFYSKLKFSRAYEELDPKEMAKEVVSAAEQRKRAQREYLMRHPNYNKSLFIFAPDNPVRRLCQRIVGPGRGHQRVEGVDPYKPVWYTFSAFVYAAIVAMVLIACITTPIYQRNYQVQWHGEAMPWYVYTDTGFAILFTIEALIKVIADGFFWTPNAYFRGSWGFIDGIVLITLWINVGSSLFKDWGVSRAIGAFKALRALRLLNVSDSAKDTFHSVIIVGGWKVIAAALVSVSFLIPFAIYGVTLYNGQMVKCNDGSIVGSLDQCINEYLSSPYNWDVLAPRVASNPFYDFDNFGDALFILFQIVSQEGWIDVQNSAMSITGKDMQPQSFAAPANGLFFIMFNLLGAVFVLTLFVSVFMRNYTEQTGVAFLTAEQRSWLELRKLLRQISPSKRSLDRKSSKWKLWCYRIAVKKHGRWARCVTVILVLHLLLLVLEFYPEPYLWELTRQALFFAFTFFYIANVLIRLLGLGWHRFSRSSWDLYSLVAVPGTFVTTILNYLLRNQVIMELNKLFLVSITLLLIPRNNQLDQLFKTAAASLTAIGNLLATWFVLFLVYAIALNQAFGLTKFGGNENNNINFRDIPRALILLFRMSCGEGWNELMEDFATMVPPFCTYDSDFFNDDCGSAAWARPLFISWNIISMYIFVSLFVSLIFESFSYVYQRSSGLYAISREEIRRFKQAWATFDPDGTGYITKEQFPRLLGELSGDFAMRIYDDEFTIGRILEKCRVDKRDSLIAHRRVVEGLDLDKLCRILRQIPVETVRKRRQRLNRFYEEVLVSADPVRGISFHSILMILAHYNVISDSKSLRLEEFLRRRARLQRVEEAVRRNTVIGFFDTLYWSREFRRKVNAKKSSRMSEVPQFTVPEIFVDDGYQEGSGTAEVGGGGSLGAPDAIVSGDEDTQPMLSPISPTRGPSSPTSSRQLPRLDTNLTGRMSNVSSPTEWSSISPSLTPGGRERSHTLSSYDAGPDVPISPTGSNHSRENSAMNVQDVMQSLDDSAWGESIRRSFTQRRSNGSQP
The following text describes a protein:
Function:
May be a carrier protein for lipids.
Subcellular Localization:
Secreted.
Sequence:
MKTVAVLLFLALAACTKQEDDDRQETIRQYRDDCIAETKVDPALIDRADNGDFTDDAKLQCFSKCFYQKAGFVSETGDLLFDVIKDKIPKEANREKALAIIDKCKELKGADSCETVYLVHKCYFLHSYGTDKKTE
The following text describes a protein:
Function:
Serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1.
Subcellular Localization:
Cell membrane; Lipid-anchor. Endomembrane system.
Sequence:
MYILFLLRFGAARRIQSVKLIALIYKGKLDNHRRIAVKRFNRKAWPDSRQFLEEAKAVGQLRNYRMANLLGCCYEGEERLLVAEFMPNETLAKHLFHCRVTPESVMYSYGTLLLDLLSGKHIPPSHALDLIRDRNIQMLIDSCLEGQFSSDACSMSLVNGLTQNLYATTTPLSPLGEACLRTDLTAIHEIIEKLGYKDDEGAATELSFQMWTNQMQDSLNFKKKGDVAFRHKDFANAILRRSLCHLMNDMPQEALNDAVQSQVISTAWHITSYLQAVSLSALGQENEGHAALKDGSMLESKRNAL
The following text describes a protein:
Function:
Catalyzes an NADPH-dependent reduction of FMN, but is also able to reduce FAD or riboflavin.
Sequence:
MRVITLAGSPRFPSRSSSLLEYAREKLNGLDVEVYHWNLQNFAPEDLLYARFDSPALKTFTEQLQQADGLIVATPVYKAAYSGALKTLLDLLPERALQGKVVLPLATGGTVAHLLAVDYALKPVLSALKAQEILHGVFADDSQVIDYHHRPQFTPNLQTRLDTALETFWQALHRRDVQVPDLLSLRGNAHA
The following text describes a protein:
Function:
Involved in sporulation and maintenance of the mitochondrial DNA. Is probably involved in a pathway contributing to genomic integrity.
Sequence:
MRKPSITITTAKAIITPDYTLIKSHSKYQLPSRFQKLDADSPERSTVVKLFYRRFMRLKPFISNVKMVKDTYRDYVRYKFMKENYELKRYLVFNPDGLRSKINLELLSNTKCCERILPVTEMQRTLEFVLKSCSYLPETKVQKWDIARDNTYCRQILKNLLTMQYEKYRSILHRGIGHDELDVKFSHLKTTSSPLTKLNKTEKKKIPLFKVFSDFDTTLIYLNETLGTRL
The following text describes a protein:
Function:
As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
Subcellular Localization:
Lysosome membrane.
Sequence:
MNQMNQPPNKCQTYLNLGSPLSAISSSPDSTKLIVAGRDIVKIVSVQNNEFKVTSNLRAGKTQSLNYTGNDCCWHPSLLENYRFLIATAATNGAVVIWNTVREGSKSVERVFTDHSRAVNKLAWHPEKLDCILTGSQDNTLRMWDIRDSANASKITFSPKSESIRDVQFNPSQANQFAAAFDNGTIQLWDIRKPTIAVEKITSHQGLVLTIDWHPEEKNIIASGGRDRAIRVWDFSNGKSLNNVSTISSVSRIKWRPGNKWHIASCSSIVDFQIHIWDVKKPYIPLFSFTDHRDVPTGLIWKSPSSLISCSKDSHLLLNEFQDSYKPYQHIRTTGITWNVNNELASINDKINRTQSNESLPSLSTQFPSFFASFNVPTPPPLPPLVKVEQGIMNIYTPKYQNSEIVYDEKYLFEHFAKNYRFRGESFNQLCDHNQFVSQSVNQHHISTMWSLLKLHYSNLDEIQQHKELIEQQQKEELEKLNNKKIEKQQPQKLKKQQQQQQQQQQQQQQQSQQQLQQPQLQQPQQQQQLQQPQQQLRQQNDKNIKEQQIQYIENLENKQLDSKNIIDNSNDSNQEININKEDKEDEEEDDDNTSNNLDDNQMGDIFDPSNDMMTAKEPPSSSLMEFNANDTGNDQFCNILSAEAVTPLVSLPTSISLERQKSTDNISDNNSNVHVNIKRQNQPTNNNNNNSNIDNLEKKSNKSKSTKENKESSLTDQNKQKRNDNKEKIDNNEIDNDNKDNNDDDDNDVDNIGEDNDEINNNNDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKNNNNDNNNNNNINNKKNKIKNKSIENKKDILDKKEINDEDNKSNDENDSLKILIPCFEFEEFNFQPIITDMLEACIEKGDVQTCVFIVLILGRYMDLNIEKHRLTTWFGSYIELLQRYKMWSLALEVMKYCDDQIINQASKRHTTLISACSSCGKSIPQNSIICEKCNKASSKCSICRLPVKGMWVWCQGCGHGGHLEHMKSWFIDKNQKSCPTGCTHICTPFKK
The following text describes a protein:
Function:
Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers.
Miscellaneous:
MISCELLANEOUS: Represent the only meiosis-specific factor encoded by the chromosome X in mouse.
Subcellular Localization:
Chromosome. Note=Forms arrays of discrete foci along synaptonemal complexes in spermatocytes and fetal oocytes.
Sequence:
MDRITDFYFLDFRESVKTLIITGNSWRLQEMIDRFFTNISNFNRESLTEIQNIQIEEIAVNLWNWAVTKRVELSVRKNQAAKLCYIACKLVYMHGISVSSEEAIQRQILMNIKTGKEWLYTGNAQIADEFFQAAMTDLERLYVRLMQSCYTEANVCVYKMIVEKGIFHVLSYQAESAVAQGDFKKASMCVLRCKDMLMRLPNMTKYLHVLCYNLGIEASKRNKYKESSFWLGQSYEIGKMDRRSVEPQMLAKTLRLLATIYLNCGGEAYYTKAFIAILIANKEHLHPAGLFLKMRILMKGNSCNEELLEAAKEILYLAMPLEFYLSIIQFLIDNKRESVGFRFLRIISDNFKSPEDRKRILLFYIDTLLQKDQDMIAEEKIKDVLKGYQTRSRLSRDLVNWLHNILWGKASRSVKVQKYADALHWYSYSLKLYEYDKADLDLIKLKRNMVSCYLSLKQLDKAKEAIAEVEQKDPTHVFTRYYIFKIAIMEGDAFRALQVVSALKKSLMDGESEDRGLIEAGVSTLTILSLSIDFALENGQQFVAERALEYLCQLSKDPKEVLGGLKCLMRIILPQAFHMPESEYKKKEMGRLWNYLNTALLKFSEYFNEAPSTLDYMVNDANWFRKIAWNLAVQSEKDLEAMKNFFMVSYKLSLFCPLDQGLLIAQKTCLLVAAAVDLDRGRKAPTICEQNMLLRTALEQIKKCKKVWNLLKKTGDFSGDDCGVLLLLYEFEVKTKTNDPSLSRFVDSVWKMPDLECRTLETMALLAMDKPAYYPTIAHKAMKKLLLMYRKQEPVDVLKYSVCMHNLIKLLVADEVWNISLYPLKEVQSHFKNTLSIIRQNEGYPEEEIVWLMIKSWNIGILMSSKNKYISAERWAAMALDFLGHLSTLKTSYEAKVNLLYANLMEILDKKTDLRSTEMTEQLRALIVPPEDQGSVSSTNVAAQNHL
The following text describes a protein:
Function:
Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate. Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production. In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro.
Subcellular Localization:
Endosome membrane. Note=Localization requires VAC14 and PIKFYVE.
Sequence:
MPTAAAPIISSVQKLVLYETRARYFLVGSNNAETKYRVLKIDRTEPKDLVIIDDRHVYTQQEVRELLGRLDLGNRTKMGQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIYIPNDSVRVTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSEMTQNRQESFDIFEDEGLITQGGSGVFGICSEPYMKYVWNGELLDIIKSTVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSSYVQVRGSVPLYWSQDISTMMPKPPITLDQADPFAHVAALHFDQMFQRFGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCSILRPDEKWNELGGCVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPHLWELPTDFYLHHKNTMRLLPTRRSYTYWWTPEVIKHLPLPYDEVICAVNLKKLIVKKFHKYEEEIDIHNEFFRPYELSSFDDTFCLAMTSSARDFMPKTVGIDPSPFTVRKPDETGKSVLGNKSNREEAVLQRKTAASAPPPPSEEAVSSSSEDDSGTDREEEGSVSQRSTPVKMTDAGDSAKVTENVVQPMKELYGINLSDGLSEEDFSIYSRFVQLGQSQHKQDKNSQQPCSRCSDGVIKLTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDSSMYREYIRNRYL
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center.
Sequence:
MAVDTDFTSLLNNLKVEDPWLPPRPWESIPTESGLSVTSTSSSSSTRFYDTSSVSEASLVRLAMNALQGLESSLISIEKLCAIFQSDPTDRTFHRIPSLWTKSVSTLALENILRSLGCMGCGVFFLYKFVNHFTCLNPDDAGLRSDENLESAGNDYPPYSLANQAFAVAVNDVLEGYVAALDTLYSSVRLRRSSNVDSVSSGCLSCVGHSEITLLEVYLHTKELRNQIEVIGSICNVHSLANSFSVSPLENLVTQTNFSDFPRGGNLLTFLYKELQVADPVHSALLRTLFIRTCEPYFDFIRSWIFKAKITDPFKEFIVAEAESNTVTIREQDGVYVPCFLKEFLIPLFRAGQQLQVLIKLLEFSDGVGSWNRTYEDFLPYWSRMSSSRLSHAFHMDFNKAGIEMMVLKRRDYYQIMMEKLKNHLPNLEFKYHQVITYATLPTSGRGSVEASSVSPAAKNMNQNLPLGTVECDASSMTDEYSYLEDSLESSECSSVEDYGEEEKTVGHIHDPDDLEKKYLSALEITSETYNIPLKTPSQDESASTMVTESHEPSHKPSHNADLAGYSTSLRSLKPCEVEHANIILGSNKLRERCSKVKLPTFDFESVKNPLTECADRLGSFYRTNGVDNMKNNNMRNNHNKGHVDDAITVKKNSFHTQASFGSKSNHQEQEPLLDVSGGGCWESLLDGTGNDNNIHPGERKTSVGPAIEIPLDFVLEKCLLEEIQLQYMYVSKLTIKLLEEGFSLQQHLLALRRYHMMESADWADLFIVSLWQHKWYAREADKRISEIQGLLELAVQRSSCEKDHYKDRLFVYMKEQDSSSLPSFTTGIQSFNGLGLGYRVDWPVSIVLTPGALKIYAQIFSFLIQVKLASSSLTEVWCSFKESIHFTNKDRSSNARKSKSRNFNIMVKLRHQIYHFVSTLQQYVQSQLSHVSWCRFLQSLKHKVKDLTDLDIVHMDYLKDSQCICFLSNDMKQIADIIQSILQCALDFRSVAALYGGLPDVSQVLTIKQTFDQNIKQLYTCYLNSPKNVEFSLPRFWEYLDYNHHYSNVINEEMGHRIFSI
The following text describes a protein:
Function:
Survival and differentiation promoting protein that plays a role in the regulation of neurosynaptogenesis. Induces phosphatase PP2A activity which results in APP dephosphorylation and inhibits BACE1-mediated processing of APP.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPGAKNRRNRNRKNENKKKAKTEKRAVVEAEGKREATDTVRSAEGKREATGAAKTQAKAISKAGPRADAVAVVKPASKNKIVTEMKEHLPDVRPKAEDEANRAARFCSAAQATAESRFTCKDKTRTDTCFGAGEEANVGSWFWNGEEIGKHFSAKDEGKADTGPPSCAEKLEPVAGTSCKARPGAEEEEEENVIGSWFWDGDETSFDPNPRPVSRIIKPQPVDEINEKDRPKDWSEVTIWPKAPAVTPAVLGFRSQVTCEKKPPSYVVLASAEENTRSSPVATAAARPSRSTPSSSQPVSEFPFGSDPCIQTIEEIRRQIRIREVNGIKPFSCPCKMECYMDSEEFERLITLLKSTTDPLIHKIAQIAMGIINVHPFAQEFINEVGVVTLIESLLSFPSSEMRKKAVITLNPPSGDERQRKVELHVKHMCKETISFPLNSPGQQSGLKILGQLTTDSNHHHIVANYFSELFHLLSLGNRKTRNLVLKVLLNMSENPTAARDMTNTESLAALKLIFNQKEAKANLVSAVAIFINIKEHIRKGSIVVVDHSSYTTLMAIFREVKVIIETM
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
Subcellular Localization:
Cytoplasm.
Domain:
The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.
Sequence:
MATKTCYYEVLKVERTATKQQVDRAYRKLAIKYHPDSNRDDGSATAKFKEATEAYEVLSDANKRARYDQYGHAGVEGATQQYGDVEDIFEAFGDLFGGGFGDFFGGGSRRGGGRRRVRRGADVRCDVTLTLEEAARGCHKDIVFRRRVSCDTCDGSGAAAGSEPVTCTMCGGQGQVIQSAGILRVQTTCPTCKGAGKQIGEPCGKCRGTGTQNEKAEMNVEIPAGVDDGMRVRLQGEGEPSPDGGPNGDCYCFISVKEHNLFKREGQHLILQMPISYAQAALGATINVPTLDGPHELTVPAGTQTGHVFTVRGQGIVDPRSGRTGDLLVQIFIEVPKKLSDKQQKLLRELAELDHDSVLPERTSFLDKLRHFFDPEPEEAGTGSTDTEKDS
The following text describes a protein:
Function:
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Subcellular Localization:
Cytoplasm.
Sequence:
MMALPKAGIIFNDIKPAAARAAAELTEKFQDAGYRVYQTTGWGGILGFPRPDSPVCHTPIDRLAAEGFDEAMPFAIVLGGDGTVLAAARQVAPFDIPLLTINTGHMGFLTEGYLNQIHPAIDTLLAGQYALEDRSMIEVRVFRDERLIWEALALNEAVLHKEPLSGICHFEVAIGRHNIVDIAADGVIVATPTGSTAYALSAGGPVITPDVQVLQLIPICPHSLAARGLVFADTESLVVHPPTNHQHLILSLDGNSGCYIWPGDQVRIRRARYRTRLIRLQPPEFFALLREKLGWGLPHIAKPLSVELP
The following text describes a protein:
Function:
Probable component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (By similarity). May also be a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (By similarity). Required for female gametophyte development and male competence.
Subcellular Localization:
Nucleus, nucleolus. Nucleus. Mitochondrion.
Sequence:
MGFFDLSIPYNEPPRSGGKEIAGGKTLRLKLATKAMELGYVGIAHNRSIKGVMSDKDSCTIPLLTLGSLIKVAPRLASSVGFHRDLLGVPRTTPFRQYTRLTVHVESNAQCQSLNSGNPILKSYDIIAVRPMNQNAFDYACEKAEVDLISIDFTDKMLFRLKHPMVKAAIQRGIYFEIKYSDILMDAQTRRQVISNAKLLVDWTRGKNLIISSGAPSVTELRGPNDVINLMFLLGLSAERARAAISKNCRNMIAKVLKKKRFHKEAVRVELLSAGDTFSLEQPLSEDCMKWDRLSSGEGDMLLDDLAKAFDATNVVAHKSSKAIDFTSVLDGLPKHGFRVKDIVGTESVTQPSAAKVIDTQVHSSNQVSELRMATASSDDNLREIETISQIDMLMSEDDNKVEPTTNVLKEEAFALRKCSASHGQGILVQNQTATPFTLTRCTKSEAASDVSMNIESTSEGGSMSPSKSDHGIPQSPVEVNNMGNAAFEEEASVDENSKERATTGHASNDEMHITESGHHASIDDEKHIPEPEHLTSIADEMKIDCSSEANHDEYMEVTMEDQMHETVQMRLCKTMTKHQD
The following text describes a protein:
Function:
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Subcellular Localization:
Nucleus.
Sequence:
MDTRFHCVYLLTSLDPQCEGAHYIGYTVNPIRRLRQHNGELVNGARRTKRNGRPWLLLMCVSGFGEDRIALKFEWCWQNPSKSTRLKSHVSQLRCVHKLTHAVGVLLLLLRTELFSRLQLTLHIFDREHFDKVISQLLSALPTMEPLVETSLLRVESTTIEQFQTQYMNDGQWGAAVDYGAYFMRAPPGANVDVSKPIVGGQDNTLRCGVMHNNLCEEEVIRQHVKERTLLESGHYPCSLCSLPLRAPYFLRCSRTPFCRLRAHIVCLAMWFIYDSSQRGGDPLVKDAGPAEVAENSNDAACQVNENCYSLSGCGPVVGGIFNHDAYTDRRDDNSPPSPPCPLPTQSSQADASLAATSLPLVPRAPCDCPLCDEELQWSALVYDLKRRVAVEKRRAERERREAMDAEFAQRFQRLQSESNKKSTARERGALEGVRRKRRRRGEVAAKLTQQTAVRHEPTSGASGDRAHSAPPAPSCGGFDEIPANVTNPTAPLHADVLQVTEFNVDEWLNH
The following text describes a protein:
Function:
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
Miscellaneous:
MISCELLANEOUS: Present with 9520 molecules/cell in log phase SD medium.
Sequence:
MTIDNYDNSKQDSSKYEVSGTGDGRNGDGGLPLVQCVARARIPTTQGPDIFLHLYSNNRDNKEHLAIVFGEDIRSRSLFRRRQCETQQDRMIRGAYIGKLYPGRTVADEDDRLGLALEFDDSTGELLASKATTWDAHNDTLVRIHSECYTGENAWSARCDCGEQFDRAGRLIACDHEPTSNIKGGNGHGVIVYLRQEGRGIGLGEKLKAYNLQDLGADTVQANLMLKHPVDARDFSLGKAILLDLGIGNVRLLTNNPEKIKQVDHAPYLKCVERVPMVPIHWTNSSEGIDSKEIEGYLRTKIERMGHLLTEPLKLHTNPQPTETSEAQNQNRMNSALSSTSTLAI
The following text describes a protein:
Function:
Important for early nematode development.
Subcellular Localization:
Nucleus envelope. Nucleus, nuclear pore complex. Note=Recruited early during nuclear envelope assembly after mitosis.
Sequence:
MSGRDLELTLDRVSSIEYPALVKEAFLNNWHASAHRSEVTSNCASLNDRYCWVLSRNQIFIWERAKSSHRAIIPTQLPLPTSGLPRSVKCVVVYDGVHRGANKTPCPGILVVSPEGVLRHWTSIESQTYIEEVLDINNEVALRVELTDEPIDGKSASFLLTTTSGTVYFLNGKGQDSAKTGALECNKVAGREAHGFRRRLSSIMFGGESKESTSLITNSFQHQSKDLLVVTVSPDVLTVYNMYTPCELWSLKTKEFFQPKIASFFEADLKRTPLKVRARLIDAAVFRDGLMILIGGTHEESQSVHMFMVWMSANWQTEQPTGVVWSARVPMNEHRALFSKIDDSIYSNLTLCIPKNTAESKKADRTDGIIIINPYFAVSLYLPFDLAKPKKPESLYRHVSIPPRDQLLGYAICSQYVYIMMLESGVSTIRLLPRGFADSSIYTHEQVVVPSLSVGTDDWPILSELLSEMVASGLPKTPLYQSLHRAFELFAEKHMAESEEELKAIIKMPDQEIARIVSQFLYAIIDYSDAANKTDTELHAKRVLTSRIMLFLKHMGVYERIISSPLGISRGGILSLRVGGTMLGEVSERVAASTAIWTWKTSNETNSAVFDAIIEKVLRIPEVQDLGLKDKDALFGRCGLVHHIPVVAAQQLEKNVIGKTKSHRFEVFHAVCELLSGIKETIISWRNCRTKVAIPKFPIWWTLETFASCYRDVAEKIIEELKNGSSTDSERARLLMYILSIYDFYLSESDSQPDNDKVLQEMIALGKPADAMELAEKHKDFGTLVKNYLTTDVGTRQKTFERYKKMFEKDDFEMYLCDYLKEHGRNDVLLQQGGSRVDAYLDNFKELRYSREIANKQFGKAALTLMSLADAETKSFSKFVEFLTRAYYCACSSIDGTDVSEVLDFYKRRYPEMKHRKRIPTEILKICFGNDLDAMMSVEDMLEWNMAVQPNDEASVEGFARAFHLLADLLAVHPDSDELKKKIDKTWKALVDYDEWNRVRSKEDVEKKTIFGKFCNYLINSYPADKGDSFPIWMPISRRLIFPTDIDTVLDECIANTTGNHLSWIKGHLKWIGEQLCKQALLPKSAFFRPDMKQVGSISQAALEAFGPILQRREQRFIDQLNRDSMMET
The following text describes a protein:
Function:
Has a role in a late stage of multivesicular body (MVB) formation. Can stimulate VPS4 ATPase activity via VTA1.
Miscellaneous:
MISCELLANEOUS: Present with 2110 molecules/cell in log phase SD medium.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Sequence:
MNRIFGYGNKKSHDQLLQESNQSMNQAQQSLSNRISQLDTQIAQLNFQLQNIQKNLQRSNNKQPSLRKQALKILNKRKQLENMKDSLDSQSWSMTQAQLTNDNLQNTMITINALKQTNNAMKAQYGKINIDKLQDMQDEMLDLIEQGDELQEVLAMNNNSGELDDISDAELDAELDALAQEDFTLPTSENSLGNDMPSYLLGANAPPAFIDEEPNLDTEDKNKALESAQ
The following text describes a protein:
Function:
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MYTLKRFGQHWLNDGAVLDRIVAAAGLACGDRVLEIGPGLGSLTARLLRQVPVVAVEIDRRAVAQLQRQFGGDKRFVLVEGDILREALPEPANVVVANIPYNISGPILAKLTGSLAQPIRRFRTIVLLVQKELGQRIAAPPGSRTYGALSVRLQYLAECELLFEVPSHCFTPPPKVDSAVIRLTPRPFALQADDPAHLDALVTRAFATRRKMLKNCLKGWVETEKLLAAFASLDISPDARAEDLSVERFVQLSNRLAESDYPSGAARGDRRA
The following text describes a protein:
Function:
Acetyltransferase that converts ornithine to N5-acetylornithine, which is likely used in plant defense.
Sequence:
MAPPTAAPEPNTVPETSPTGHRMFSRIRLATPTDVPFIHKLIHQMAVFERLTHLFVATESGLASTLFNSRPFQAVTVFLLEISPSPFPTTHDASSPDFTPFLETHKVDLPIEDPDREKFLPDKLNDVVVAGFVLFFPNYPSFLAKQGFYIEDIFMREPYRRKGFGKLLLTAVAKQAVKLGVGRVEWIVIDWNVNAINFYEQMGAQVFKEWRLCRLTGDALQAIDKLNI