lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MLLLLLLLKISTFVDSFQIGHLEFENSNETRILEICMKNAGSWRDHRLISLPSCHNFNGLENAANLNYQYSVDLLIGAACDEETQTVSRLALRWHKLYLSSAPLSTKEKESTTIALKPHSLAGTAEVILAMCKSMKWKEIGIIYSEETKYTAHAIYDMLAEQEDDLKINVFLETDGLSNTYTILHSARALISFLTTLDLSKFFKTLKENAFRPLEFSIVHVDCNKSEISNFYTYLDNNAGEEPNPISAARLRKLYRHVALLKNSHDDMEKTEEFAKKYGLVPSYTLYKALILCDGLQLLNNYTAPRGNLSIVQQLPYLWNHVTNTETQGYSGPVFIGNDGVRLPYYEMHMWRDGKAVHVANVKPRESDYCGGNMTKNCYEFLPSSPLLEDLPPYTSDCGYDNNLCSDFHVFMIAAIVFSILLIPMAIAFYLQRKEHLIQQMPWRVPLDSISFDDNGGSLSASRRVSTISTARASYSSIFSGNVAEHAIVNKQKVSVKRHVQRRAITFSRQEMEMLNQLKYMSHTNINPFTGICFNQGSELIVMWQFTTRYSLEDLIFVKEQKFGRNFQSTFIKHIVHGINYIHNSSIKVHGALYLSNCVVDSYWVVKLTDFGIKGILKERTNHKELAPSSAFDVDAIHYKYLQLAPEHISAILEKLEEPRGTVEGDIYQLAMCIYQILFYMRPFAERQESIKELAHLLSSQSTAPLHPKVPEGNSFTMRLLSIIQQCWLYKPAARPALIKITDAVNREFGQDVKGTLIDQMIEMIDEYSANLEQIVAERTRELEQDMSVTENLLYQLLPKSVADSIRSGKTVVPEQHSSVTLLVVDVCQFTKFCEAFIPVHILETLQELYSSFDNIVQKNKAFKVENVGDAYLICSGIPEMSGFRHLREICKISLKLQAFMKTFKVRHRPSHTLQIKMGITSGAVAAGILGSTAPRFCIFGDTVNMACRMASTGNPGSIQLSELTANTLMEKFPSFMLEERGMIDVKGKGACLTFWLTGEKDIMRRQSSRSSCISQIKFELDEADNSKKMFLNV
The following text describes a protein:
Function:
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.
Subcellular Localization:
Nucleus.
Sequence:
MSGWDREASRSGSGDGRIYVGNLPSDIREKELEDLFDRYGRIRTVELKNRGGSSAPFAFISYQDPRDAEDAVFGRNGYDFGSCRLRVEFPRSFRGSGGGGGGGGGYGGSRGRNGPPSRRSEYRVIVSGLPPSGSWQDLKDHMREAGDVCYADVHKDGMGIVEFIRKEDMEYALRKLDDTKFRSHEGETSYIRVSPERNTSYSRSRSRSRGRDSPYQSRRSPRYSSPFRQY
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MEEIGKEGKRKRKEEKGKKEKKRHKGKAGGILTNKLFSELDISELTAKAVREMNYTHLTQIQARSIPHLMLGSDVLGSARTGSGKTLAFLIPAIELLHKARFTPTNGTGVIVVCPTRELAMQTHNVAKELMKYHLQTLGYVIGGTNIRSEANQLVEGVNLLIATPGRLLDHLRSTTGFNYRGLQCLVIDEADRILEQNFEEDMKQIFKHLPRDRQTVLFSATQTKRVEDFANLTFGRNEERQRKLVYVGVDDSELKPTVEGLQQGYCVIPSEERFLVLYAFLRRMQLKQKVKVMVFFSSCSSVKFHAELLNFLGIECYDIHGQLKQQKRTTTFFRFSKEEKGILLCTNVAARGLDIPDVDYIVQFDPPDDPKDYIHRVGRTARGDKGKGRALLFLLPEEMKLLIYLRVSNISLTEYTFSGKHVPKLQPQLEKIVAENYFLKQSAKEAYRSYLLAYNSHSMKDIFGVHQLDLKNVATSFCFNSPPKVNLNLESSASKHRKMRKVDGGKGHGISHSSPYGRSGGIDRRQFARF
The following text describes a protein:
Function:
Required for vacuolar protein sorting.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.
Sequence:
MFNAPRPMASSYSYTDPLSNSAAAGAAFGELDPWSSAPSPAGSVTPARATASASEGRNIAANGNKEEGLNGLINDPPALYVSLLDQLDTSGTGEVSLAAVHRLLGTSKLPAVVVEKIIHLTSRDKSTLTRPEFFCALALVSLAQSSPDPNDISIEKLSFSLSNLPLPKLKPSDPPSVSSGVAASTAAATGFNAWDGTINKGTTYSANNSTFRSTDPMVDNAEDRWWKDQERIVVTLIPEKEGWFLQKYRIESDKRGEGPVARRYSDFVWLMDVLEKRYPFRILPPLPPKRINPSSAFLEARRLALIRLLSFLTAHPVLRTDACLNIFLTSSSFESWRKRTPVSTDEESLSKKLTTAQEMSIPSDLELKLDNLRERLPAMLGHYTRLVVMAERSLVRLQVQAAEAARMAMSTQSIGELVPRCCWRSVQGDDGESGRGVARECGLCEGVGRGWGDVGDGWVSVGEELEKGVQLLQKHIESLKSQRDLYSSFHALFYRHNKLSLDNVDVLRKRVDSRFSKIESLKSAKKPGWEGEVDKLASQSDRDTAEIQRLLARRVFVRACMWHELSVVFHSMQAAQGTMGWKDFVKDQKERTKRLNGVWQGLEETLESMPLE
The following text describes a protein:
Function:
Receptor for cAMP.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGIEESQICNPSDREFLSVDILNIVTSSLSLMGSALTIISYIWKKVRRHRIQKQQIQQQQQQIEKGGLLSSSITIGNGSSHYGGIGGGGGSGNGTGIGAIGGPHGTYKQPTSKLPLLIFMLSIADFFTSFFIIISQSYLINNSKSYSTPYSPDLKIHFSPCIILRAIIQFFFLSTFFWTTCISYYLFHQLSSPGEEKYLLAIFNVVSWGIPFAISMVITMTNSIVVNSDGWCEVAKPMELSLWFLPLFLCLLVCSIYYFRLRRLFRSKFEYRLQINDRLKQLDSTISRRLTLYIVVFVICWLPDVIQHFISFFSKCTFFPLLILQNILTPSQGFWNFWIYSYTNKIARFTPSNDENKRLLQ
The following text describes a protein:
Function:
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
Sequence:
MSVVGSFEQLERLRDLFYKLLDLRDTLRERGVAWPKPLSEEAALGTVRVKVGFPAMLKRGVIMDVTNVEQAQIAEDAGAVGVMVLDKLPYDVRRAGGVARMADLKVIEEVMAHVTIPVSAKVRIGHYYEAFLLEQVGVDLIDESEVLTPVDEQHHINKWMFTVPFVNGARELCEALRRISEGASMIRSKGEAGTGNVAEAVKHFKSIYGAIKSLAAGDEERVRDFARQCQVPFELVALTAKLQRLPVITFAAGGIATPADAALMMWLGADGVFVGSGIFKSQDPRERAEAIVLATAHWDDPETVVEAQKMVSERGAMMGIDIRTLKPEELLQTRGV
The following text describes a protein:
Function:
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
Subcellular Localization:
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Domain:
The N-terminal domain does not have lytic activity and probably modulates enzymatic activity. The C-terminal domain is the catalytic active domain.
Sequence:
MFALTAYRLRCAAWLLATGIFLLLAGCSEAKAPTALERVQKEGVLRVITRNSPATYFQDRNGETGFEYELAKRFAERLGVELKIETADNLDDLYAQLSREGGPALAAAGLTPGREDDASVRYSHTYLDVTPQIIYRNGQQRPTRPEDLVGKRIMVLKGSSHAEQLAELKKQYPELKYEESDAVEVVDLLRMVDVGDIDLTLVDSNELAMNQVYFPNVRVAFDFGEARGLAWALPGGDDDSLMNEVNAFLDQAKKEGLLQRLKDRYYGHVDVLGYVGAYTFAQHLQQRLPRYESHFKQSGKQLDTDWRLLAAIGYQESLWQPGATSKTGVRGLMMLTNRTAQAMGVSNRLDPKQSIQGGSKYFVQIRSELPESIKEPDRSWFALAAYNIGGAHLEDARKMAEKEGLNPNKWLDVKKMLPRLAQKQWYAKTRYGYARGGETVHFVQNVRRYYDILTWVTQPQMEGSQIAESGLHLPGVNKTRPEEDSGDEKL
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Sequence:
MELSISMGGSAVATGLVNLKMVNHKCTRGLGRQLQFSHDVPSSVCLMIFNKEFSKRINHKVCGALQAVSPVQCTENPTQAPVAFKDFHVSVLTEEDGVIETQIRVTISSKMTDSVFEKVLSKHIAAAQPLPGFRRLKGGKTPNVPKEVALHLIGPSKVKKAAIKKIINRAVAEYVEKENLDAAKNLKVLQSYEELEATFEPGKEFCFDAAVHLTGS
The following text describes a protein:
Function:
Transcription factor involved in sexual reproduction. Required for cleistothecial development and ascosporogenesis. Not required for asexual reproduction (conidiation). May act to repress medA expression.
Subcellular Localization:
Nucleus.
Sequence:
MYSQHGAPMAPPQKPETFMLSNEAQQSLPHDAQVALQQVDNLKYFLLSAPVDWQPDQLIRRFLLPTGDYISCVLWSNLFHISGTDIVRCLAFRFQAFGRPVKNSKKFEEGIFSDLRNLKAGTDATLEEPKSPFLDFLYKNNCIRTQKKQKVFYWYSVPHDRLFLDALERDLKREKMGQEATTVAVSEPALSFEFDSSQSLYEQLTKAQQANSSSFAAHASTTYGQSASPVVRTVDAMPPPQMAPQMAPPSIPLLTDESANSQMYTSIPMPNPIPQNLIKREADYGAIQYDRNGMPIARIHQRHSSMPTFVEYSPAPSFVSSQYEDYSNRGLSFEPVTPPQHSSHIGPEPAYIANEDTGLYTAIPEMSTGSGFNPMMHLPPSNLASAHFPTPARTFHSNVYSVLEGSPTYKQRRRRSSIPPGAANPVTTGTHSPAPALSYAAHKPSDLRRSVSSSVAPGDTDDSRHESLHRSVNSTYTATLPQKNLMHEMSRNGTPLSSVGEHREQSSIPLTQAEDLPALPANGTVESGAPNGVGHKSDRYATGPVRRARSATMMELGPYPQKSHSCPIPSCGRLFKRLEHLKRHVRTHTQERPYPCPYCNKAFSRSDNLAQHRRIHEAQQDGQPLVHEDDLENDDNESVSHDEDESPSESVHPAVPGVHGMTSMPSSVALQSTMGSMMGSHMIAPQLLQQQI
The following text describes a protein:
Function:
Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MNALLRHKGRNLRTSHLAQNVYKRFLKSNCCACSSVNVTDEPAKEDELPRRSASTSVLELSRSLGTYRRFQPHANYGYDYSGYGFRHLHTSRTLLETSSSKIDATVKKLKNQQKEKVEEIMKEVANGQAAAVRASSAATATASSEKGQNASATAGSTSATASTTSLAKTADKSVAKPKKPLRTRIWDELVHYYHGFRLLFIDVAICSKLLWRVLNGKTLTRRENKQLQRTTSDLFRLIPFSVFIIVPFMELLLPLFIKFFPGMLPSTFQTSTDRQEKLRQSLSVRLEVAKFLQQTLDQMPVQHKEHSSEEAKQFEAFFTKIRNPTEPVSNDEIIKFAKRFDDEITLDSLSREQLAALCRVLELNTIGTTTLLRFQLRLKLRSLATDDRVIAREGVDSLDLLELQQACKARGMRAYGLTEERLRFQLKEWIDLSLNEQVPPTLLLLSRTMLISDDSITTDKLKETIRVLPDAVGAHTRHAIGESEGKVDNKTKIEIIKEEERKIREEREEEREETIAKRSAIKEEIPAPYVFAEKLSGSQDLLDHKEQSSVSETDKGISSTDVQLLSEALKTLSSDKQLVVEKETIKELKEELADYKEDVEELREVRQVVKEPVRESRAAKLLYNRVNKMISQLDNVLNDLEARQHQIKQAESSDYAASSPTVEPQQMVHIDELVATIRRMKEASDEERFKVVGDLLVKLDADKDGVISVNEITKAVQSIDREATNIDKKQLEEFTELLSKLASRRRHEEIVHIDDLMNNIKVLKETSDEARLKHIEAVLEKFDADKDGVVTVNDIRKVLESIGRDNIKLSDKAIEELISLLDKEQVLQAEQKIEKAIAKSMKEAEKLKSEVDKADKDLSKLVNDIHDSAKEIQDIANEMRDKEETVPDKAKELKAEPAFKDTAKTLKDNAKDLDDLAKDPKSDPKSPTKASTGSGPAGLSGGGPSSGSSGIATGSTTESALREAAERQMEKILPSTDIGLPPTIQTPSQPPTSKKATATASTLSTTITAKKLL
The following text describes a protein:
Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
Miscellaneous:
MISCELLANEOUS: Present with 1480 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNGLRVAAKIQPARQTIIFLHGLGDTGSGWGFLAQYLQQRDPAAFQHTNFVFPNAPELHVTANGGALMPAWFDILEWDPSFSKVDSDGFMNSLNSIEKTVKQEIDKGIKPEQIIIGGFSQGAALALATSVTLPWKIGGIVALSGFCSIPGILKQHKNGINVKTPIFHGHGDMDPVVPIGLGIKAKQFYQDSCEIQNYEFKVYKGMAHSTVPDELEDLASFIKKSLSS
The following text describes a protein:
Function:
Transcription factor that regulates metabolic homeostasis in response to oxidative stress (By similarity). Binds to the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (By similarity). Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). May act as a positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and nucleus.
Sequence:
MAEPQQQLVDIDPDFEPLSRPRSCTWPLHRPEFSEQPGNSNTSSPAPSVKPEQGIVDFINSLSLLEETEDYPDEKPVLLNDFHCQDNCAHPQQQHPQQPNPQLTHPQQVPPLPAPASGSSPAAAQRKSSSSRRNAWGNMSYADLITKAIESSPEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFVRVQNEGTGKSSWWMLNPEGGKSGKSPRRRATSMDNNSKFTKSRGRAAKKKMSLQGGLDGGSNSPGSQYPKWLGSPNSHSNDDFEPWGNFRTRASSDASTLSGRRSPFLPEEDEAAEVHIGYPGTKLGGPLPSLSEVAGHHGSENMMDNLLENLNLISPKNNTQGSQEAQTALSSPLMQGSPGYPSYTSPNMGPQPQVQQDYRKCLYGQGGVGGLNPISIPTLSDSKPGGYGPFVGQYNCAPGLLKELLTADADPRGELMQSGEGQPVLPSYASQGQMAQGGKMITHPHLHAHPRSLHQLPSPAMGLNGCAMLPHGHPVRLSSMKPQPHLPHHTHLGRGGGEAGMPSYTNGNGFHRHGAIAHHHHSHPERLPSDLDDMLIDQLDVECDVERVLHDTLMDGDALDFNFDPMSSQQSFTHSVKTSTHNWVSG
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHISNRKISSTEISKRKLLKNLRNEYIGRGLSTICGVLIVFLTLSIIFFVALKGIAVFSKGVSLKEFLFSTNWSPDNDVPRFGALNFIAGSTFVSIGAVILSAPVSIALAIFINYISPKLGDKVLKPALELFVGIPSVVYGWLGISILLPIIKRIYGGTGFSILAGIIVLSIMILPTIASISVDAIKVVPKSYLQASYGLGATRWQTISNVIVPSAKDGILTGIILGLARAFGEALAVQMVIGNSIQFPNKLLNPASTLTSVITMDMANTIGGTVWNDALWALALLLLIISFLFIIAIRIISRRRED
The following text describes a protein:
Function:
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
Sequence:
MTIPLTLKQRATGAQPRAMRREGRIPAVLYGHRGTQSLALELEQRTAEDLLKRVTINNTILPLKVERGWSGDVLLREVQHDAVGGKLLHLSFFAVAGHGSITLDLPLVFTGEAVGVKMDGGLLEKVLTQLTVNTPPTDVPEAIEVDISTMQVGDMLYVKDLVLPPGIEVVNTPDLVVAHLTPSPTGRALQSMDAAESAVEQPGEQPATAAG
The following text describes a protein:
Function:
Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites.
Miscellaneous:
MISCELLANEOUS: Named after the expression pattern, which decreases in a posterior to anterior direction in somites like a ripple.
Subcellular Localization:
Nucleus.
Domain:
The ripply homology domain is required for transcriptional repression; The WRPW motif is required for binding to tle/groucho proteins.
Sequence:
MNSVCFATPHTKHMDSKMQLTSSPASLWRPWLVTRKDAQTECRRTKLACPYSRPEVPGNTTTDGKMQSFQHPVRLYWPRSKSFDYLFSDGEALLRNFPVQATINFYDESDSEDEEESCDEDDESDVEDCLKHNSHFTAFN
The following text describes a protein:
Function:
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. Binds single-stranded DNA (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPPKRRQAEDTSDAEPQYTKKSKGNTGKAQPQELTKGSDQDGNTFWELGNNRRISSSVFRNTTLVNIREYYDAGGKLMPGKKGISLSLAQYQNLLKVIPQLNADLRAQGHAIEDPGFAQVAEQTDAPIETPKVKALESNKESIKKEKKKPRKSNIDVTSDEEEAAEDEDDDE
The following text describes a protein:
Function:
Modulates cell-to-cell trafficking.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction, plasmodesma. Note=Co-localizes with the Grapevine fanleaf virus (GFLV) 2B-MP at the base of tubules within modified plasmodesmata.
Sequence:
MPMAKLRNIIKTLSIFFFLIAATAPSLSSATSATDTFVFGGCSQQKFSPASAYESNLNSLLTSLVNSATYSSYNNFTIMGSSSSDTARGLFQCRGDLSMPDCATCVARAVSQVGPLCPFTCGGALQLAGCYIKYDNISFLGQEDKTVVLKKCGSSEGYNTDGISRRDAVLTELVNGGGYFRAGGSGDVQGMGQCVGDLTVSECQDCLGTAIGRLKNDCGTAVFGDMFLAKCYARYSTDGAQHYAKSHNYKTNYGGEKTFAIIIGLLAAVVLLIIFLLFLRGVCSRGGDFSILHSFTLI
The following text describes a protein:
Function:
Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Only supported by readthrough transcripts formed via the splicing of exons from UCHL5IP and TREX2 genes.
Subcellular Localization:
Nucleus.
Sequence:
MSEAPRAETFVFLDLEATGLPSVEPEIAELSLFAVHRSSLENPEHDESGALVLPRVLDKLTLCMCPERPFTAKASEITGLSSEGLARCRKAGFDGAVVRTLQAFLSRQAGPICLVAHNGFDYDFPLLCAELRRLGARLPRDTVCLDTLPALRGLDRAHSHGTRARGRQGYSLGSLFHRYFRAEPSAAHSAEGDVHTLLLIFLHRAAELLAWADEQARGWAHIEPMYLPPDDPSLEA
The following text describes a protein:
Function:
Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll. Also has a role in pupal pattern formation.
Subcellular Localization:
Cytoplasm. Cell membrane. Note=Associates with the plasma membrane during interphase syncytial blastoderm embryos, more specifically at the membrane invaginations around the nuclei. Later in embryonic development protein is entirely cytoplasmic.
Sequence:
MAYGWNGCGMGVQVNGSNGAIGLSSKYSRNTELRRVEDNDIYRLAKILDENSCWRKLMSIIPKGMDVQACSGAGCLNFPAEIKKGFKYTAQDVFQIDEAANRLPPDQSKSQMMIDEWKTSGKLNERPTVGVLLQLLVQAELFSAADFVALDFLNESTPARPVDGPGALISLELLEEEMEVDNEGLSLKYQSSTATLGADAQGSVGLNLDNFEKDIVRRDKSVPQPSGNTPPIAPPRRQQRSTTNSNFATLTGTGTTSTTIPNVPNLTILNPSEQIQEPVLQPRPMNIPDLSILISNSGDLRATVSDNPSNRTSSTDPPNIPRITLLIDNSGDVNSRPNHAPAKASTATTSTASSNNLPMISALNISKGSRETLRPESRSSSSSLSKDDDDDNDGEEDGEEEYPDAFLPNLSNSEQQSSNNDSSLTTVTGTSGDNSFELTNDSSSTSNDDYACNIPDLSELQQ
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and acts as a regulator of mTOR signaling.
Subcellular Localization:
Cytoplasm.
Sequence:
MTQQSSGIQNLDGKRTAEGDEDSYTDSLMSNENARPGETNLQEELQMFRARWMSELTPGLSSGGLANRPIYAAARGPVGKVSETKAKQELAKEEKARELFLKAAEEEENGALYEAIKFYRQAMQLVPDIEFKINYTWSPDGDGKNFMDDANIESKMADLLAYFQQQLTFQQFKLCQPDIDVTQTHISVLPMEVLMYIFRWVVSSDLDLRALEQLSLVCKGFYICARDPEIWRLACLKVWGRNCVKIVPYITWRQMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYLRFFPDGHVIMLTTPEDPQTIVSRLRTRNARTDAMLLGHYRFSQDTDNQTKVFAVITNKKEEKPSDYQKYRYFRRPQVPETERSFHMGLQLCSSGRHKFNKLVWIHHSCHITYKSTGETAVTAFDIDKMYTPLFFARVKSFTAASERPL
The following text describes a protein:
Function:
Involved in the non-phosphorylated metabolic pathway of L-rhamnose catabolism. Catalyzes the oxidation of L-rhamnose to yield L-rhamnono-1,4-lactone. It can also oxidize L-lyxose and L-mannose, and uses only NADP.
Sequence:
MLDFKGKNAVITGGSRGIGRAIALGLAKQGANILISYASHDSEADEVLETASKYGVKAHKVKVDQSDPYESIRFAEKAIETFGKVHILVDNAGICPFEDFFRISVDLFEKVWKVNVESHYFITQRIAKNMIENKINGRILLISSISAHVGGEFQTHYTTTKSALNGFMHSIAIVLGKYGILVNSLEPGTILTDINKEDLSNQEKRAYMERRTVVGRLGLPEDMVAPALFLLSDDNTYVTGTELLADGGMLINLQ
The following text describes a protein:
Function:
During host cell infection by tachyzoites, required for tethering the parasitophorous vacuole to the host mitochondria. This process, known as host mitochondrial association (HMA), induces the formation of SPOTs (structures positive for outer mitochondrial membrane (OMM)), a cellular response to OMM stress, which leads to the constitutive shedding of OMM vesicles containing proteins such as mitofusins MFN1 and MFN2, which normally restrict parasite growth. Specifically, binds to the host OMM import receptor TOMM70 to interact with SAMM50, a component of host mitochondrial intermembrane space bridging (MIB) complex. By targeting SAMM50, induces the disassembly of the MIB complex, thereby promoting the formation of SPOTs. Inhibits host TOMM70 import activity. Plays a role in the modulation of the host innate immune response to parasite infection.
Subcellular Localization:
Parasitophorous vacuole membrane; Single-pass type I membrane protein. Cytoplasmic granule membrane; Single-pass type I membrane protein. Note=Localizes to dense granules. Localizes at the interface between the parasitophorous vacuole and the host outer mitochondrial membrane.
Domain:
The proline-rich region is not required for host mitochondrial association (HMA).
Sequence:
MWRIWRCRLSFLFATGCLLGALTAGLGSQMSDSVGRNVQAPAGVADASQEAGDVVEERTERTEEQAFALGPPRRHSSESLFPRNASVTARRRRNRRIALIATAVGVAVILAAVYVLRRRRAQRPQDPEPPAPRSVEDPEVLPEEDEASSSLPPPPPPSPPPPPPVEDPLSPESQTVDLSCLSGTTVRFFGPSHHFGGFTPLYDPAPDKRVATVDAGANALFIGGGGLNGQFAKTLLEEAEKHGIRLTPEELSQHSQRIQQSLLRRAVKSPGKLVELDTGVASPVFARSFGFVPVVPGLMWEESEVGPNVGVTFVHILKPEVTPYGNLNNNVMMYTVAPSGAAPDKTYSLAYKTTIAGVIGAAAAYNDTPAGQQYPVQGLRLPLLGGGIFRRNRSLESIGRANAEGTSLAITRYGPNFELQYMYDPSNAALHGLQEAESTYLASMLD
The following text describes a protein:
Function:
Translation factor required for the incorporation of the rare amino acid selenocysteine encoded by UGA codons. Replaces the eRF1-eRF3-GTP ternary complex for the insertion of selenocysteine directed by the UGA codon. Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling. (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation. (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAMAGSAEGDGTATLNFNVGVLGHVDSGKTSLARALSSTASTAAFDKNPQSRERGITLDLGFSSFSVELPEHLREQCRERGFSRLQFTLVDCPGHASLIRTIIGGAQIIDLMMLVVDVTKGVQTQTAECLVIGEMTCPRMVVVLNKTDLLPAAKRQATIDKMTKRMLKTLENTRFQGCPVIAVAAKPGGPEAPDTELPQGVPELIELLKAQAYLPHRDPSGPFLMAVDHCFSIRGQGTVMTGTVLQGAVSLNDGIEIPALKVTRKVKSLQMFRRAVSRAMQGDRVGVCVTQFDPKLLERGVVCTPESLRTLHAAVVSVRKIGYYRGALPTRSKFHITIGHETVMARVTFFGPAPAEAGPAPAEAGPAHSFSFDRDYLFQEEYVTGQPGAAGEAPDPEQWALLEFEKPVTCPPLCLVIGSKLDTDIHANTCRLAFHGRLLCGFEDRGYAETELPRLRIYKTKQREGQVERVTDDYTVIGRNLFKKETNLQLFVGLKVTLSTGETGVIEGGFGQSGKFKIRVPGVWSEDPAVPVSPCVLQEFCLCSSFSSLGTLLCLPLSPLPLPPSCPASGSVCIQDVVRNRRPGILNPISESILEIPLWEFCPGNSVGFRGKSAFLFILAFYD
The following text describes a protein:
Function:
Could act as an H1-type linker histone.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MPPKKAPTTAKKAASGPTHTSYRDMIKDAILNLKERNGSSRQSIKKYVLANNKLAPASQNAFDSQFNKAIKAGVEKGDFIQPKGTSGPVKLAKKQAPAKPAPKKPATTTKTAAPKKTATKKADKAEKAEKPKTKKTNAGVKKPAGRPKANTAKPRKASTAAPAVVDKPKVVSVTKSGRKTTTTAKPTEKATKKTAKNKKA
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAADLVTVLAEGTFEEQIVEVSAFLSRSQPEASRNDFISKFQQLALDAEPAEPAEPAVSTEATEPASAPDAAKKQQTVQQLVSEIVTLGEGSDRELEGVYNLIFSLISSTDQQTQLVPQLLSAVSKDSAAAATGAGGADKSNVRYRILSNLFNSLEATSALRLQTFNALLSLVAANDDLDYLTSALTALPQWLAQWSVSETEKASCLESVAKALEGAEKEHGQTSKAYQFLVLHLRYISTLPASASTKEAAERTVAAALRLPRLYEFEDLLHVQAVLDLKSASSPIFDLLKIFVGGTTADFSAFASSHSSEFQRLNLSHDDLLHKIRLLDLADLCALRVSADVSYASIAKTLNIEHDQVELWVIDVIRAGLVSGKLSQVNDAFRVYKSTHRQFGKEQWQSLEQRLVQWQNSISSIIESIAATRGGKLPDGAPVAAELATA
The following text describes a protein:
Function:
Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.
Subcellular Localization:
Cytoplasm.
Sequence:
MRGGDAGAAAAEAGSPRSPDLYDFSDDSDYAAASHHTAMRTDSVDRGSDETARIDVVYEKERVTIHLTQYGSGRISGKLRLFLQRGSLFLSWEPNEGADSLSTSSIGVEIEKYRNLYTIKALPLSDVRFIRRHTPTFRLDYIIIVLSSGLAYPPFYFYNGGIRELFATLKQHVFIIRSDDDPNVFLVNDFQDPLQKSLSSLELPGVASVANAMSRQNSLSFTGANDESRHGTDGRHGEASSISQYGSKQKNKSNDPGRDLSIQVLEKFSLVTKFARDTTSSLFQNNSGAHAYGRQQHEYLLDNEASDKQKNQYITPEKASMPSAPPEPDPLPLVWGKQRDRPLSAEEWAAFLDPEGRVMDSKALRKKVFYGGVDHVLREKVWKFLLGYHEYDSTYAEREYHAAMKRAEYEAIKSQWKSITATQAKRFTKFRERKGLIDKDVVRTDRSVPYYEGDDNRNVVVLRDILLTYSFYNFDLGYCQGMSDFLAPILYVMEDESESFWCFASLMERLGANFNRDQNGMHAQLLALSKLVELLDPPLHNYFRQNDCLNYFFCFRWVLIQFKREFSFDQIMLLWEVLWTHYLSEHFHLYLCVAILKRYRQRIIGEQMDFDTLLKFINELSGQINLDRALQDAEALCTIAGENGASCIPPGTPPSMPIETDGGLYVQQDDVL
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSNNANNCLPLASYTLAVFPGIPVAPIEQDFPVSVRITMAAIDPARIEGDEEEPATLRILKPADNFDDEDDEDDEDEDDDDEDDEVSAEDMAQIKKLIAANEDGLDEVEGGDDDEDDDEDDEMEFEEDDEDDDDEGEIEDFVVCTLSPKFGYQQTLDLVITPGEQIMFEVTGSYAIHLSGNYIEHPYDMEDEDELLALGEDDEDDEDELDEGEYDLSPDEDEVINGDERLVELMEQDDEDDEDDEDEEEEPVVEPKKILKRAAEEKKQEKAAKKAKVAFTKNLEQGPTPSEPKPKLVTRQLEGGVKIEDRTVGEGPSAKVGSKVGVRYVGKLANGKVFDSNSKGKPFYFSVGKGEVIRGWDIGVQGMKVKGERRIIIPPGMAYGKQKLPGIPPNSQLTFDVKVVNIK
The following text describes a protein:
Function:
Hydrolyzes double-stranded DNA with no sequence specificity. Does not cleave ssDNA and RNA. May facilitate blood meal intake by lowering the local viscosity created by the release of host DNA.
Subcellular Localization:
Secreted.
Sequence:
MSSFFLSISPLVLALFHVVVQVCSQSCQVAISELQSERKVIILNSDKRSLKQPSNGKYSWKSGESIYFICGKDLKTLTCSPSSINAKRFDCVKPPDVTERDINRECNGKSSKTFQMGFRASGGLFVPYYELCYLMDTCSVSHVKHRLLGASFGGVSGTREKSFQSFVCPGLRYNTHYTQASQKQPDPRFYFQRGHLFPDRDAPVFAWKLATYSYGNCVPQWNTINSEGGNWWTLEYLVFKYAQQTPNTEYTIYDGVLYDPRNKQYLAKQEKKIEIPVWFWKVVTNQTHVLKVFFVSHNLKGTKQTFCNTNRCVNDRAKGTKTVETWDFYNEASRGITHCCYWKDLARKNPLPIEVQREINNKKN
The following text describes a protein:
Function:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Subcellular Localization:
Nucleus.
Sequence:
MVVKTRGRPATKAAAVEAEPSKAADPKVKLQPDDTNPPRVFILPKDISTEARIITLANPRYAKDSRYLVCPDRGFNEFTRIAAPKITPRSWLLVPENGPAVPLSEQLLNDEANDKGESSTKGYVTKGADLFIATPIDSLFIILPALVPLSTTKASDPPKRLFLSGEDYIDKLISISPHLRSFLRTGPLRTSLEKRMAAVCDTADAGDETMLRINEEKLFSELLQKAKKMAEHGLPASMEEKLIRKALDTPVLSINRGEESTHEGSKEEANTSAESGTSTPRTDSQDTQATDLSVDTAASSLSEASTAATSISSHSAVASEDEKISVPSIDAPEGVADLLRIRTAFFFICSNYIAPHLSEILKKSLKSSASPVDFTPLDSHLAYLTKLRQDAMAARSMGDYSRKRAMVGDDEEIETRAEKKRKQDEEDRRRKAGESRGVKNLKKVNTSGMKKMSDFFKKK