lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Distal (knob) tail protein that plugs the end of the tube before DNA ejection and forms a channel perforating the host membrane during ejection.
Subcellular Localization:
Virion. Note=Present in 6 copies in the virion. Located at the tip of the tail and constitutes most of the tail knob.
Sequence:
MAYVPLSGTNVRILADVPFSNDYKNTRWFTSSSNQYNWFNRKSRVYEMSKVTFMGFRENKPYVSVSLPIDKLYSASYIMFQNADYGNKWFYAFVTELEFKNSAVTYVHFEIDVLQTWMFDMKFQESFIVREHVKLWNDDGTPTINTIDEGLSYGSEYDIVSVENHKPYDDMMFLVIISKSIMHGTPGEEESRLNDINASLNGMPQPLCYYIHPFYKDGKVPKTYIGDNNANLSPIVNMLTNIFSQKSAVNDIVNMYVTDYIGLKLDYKNGDKELKLDKDMFEQAGIADDKHGNVDTIFVKKIPDYEALEIDTGDKWGGFTKDQESKLMMYPYCVTEITDFKGNHMNLKTEYINNSKLKIQVRGSLGVSNKVAYSVQDYNADSALSGGNRLTASLDSSLINNNPNDIAILNDYLSAYLQGNKNSLENQKSSILFNGIMGMIGGGISAGASAAGGSALGMASSVTGMTSTAGNAVLQMQAMQAKQADIANIPPQLTKMGGNTAFDYGNGYRGVYVIKKQLKAEYRRSLSSFFHKYGYKINRVKKPNLRTRKAFNYVQTKDCFISGDINNNDLQEIRTIFDNGITLWHTDNIGNYSVENELR
The following text describes a protein:
Function:
Catalyzes the Claisen rearrangement of chorismate to prephenate.
Sequence:
MTRLTDGLRGCALTGVLAVVLLGCALPARSQPPLAPLLDKIAERNAIGDAVALSKWDSGKPVLDQAREAAVLQNVRDQAPAHGLDPDDAARFFGAQIEANKSVQYALLNRWHERGRAPDTARPDLSTLRERLDAVQGELLDALAEAAAARAAPNCPASTARAAAQYSAQWQLDAVHRAALVRGLGDFCR
The following text describes a protein:
Function:
Senses unfolded proteins in the lumen of the endoplasmic reticulum (ER) via its N-terminal domain which leads to enzyme auto-activation (By similarity). The active endoribonuclease domain responds by cleaving an intron from the downstream cytoplasmic mRNA hacA, allowing for the translation of a transcription factor that coordinates a series of adaptive responses that are collectively known as the unfolded protein response (UPR). In the absence of ER stress, ireA controls dual signaling circuits that are both hacA-dependent and hacA-independent and which contribute to the expression of traits that are essential for virulence.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MRWRLPGARTTLPASVALLLLPILVAPQQLQEHDDLPSTLSVPLSPTQRSFDHHPLPTINVKSNDASALATMALAGPGRAVRARPAQASSSSAGLAPQLHARSLQDWEVEDFVLLATVDGSIHARDRRTGAARWALEVPSSPMVESIYHRANRSSFDRAQPEDDFLWIVEPSQDGNLYIYSPGPDAGLQKLGLTVKELVEQTPYSGTDPAVTYTARKETTLYTVDARTGNILQVFSSRGPITSGHGCRKVDGFDLEAEECDTPSGTLVLGRVEYAVAIQNTETGDPICTLKYSEWTANNRDMDLQSQYFRTMDQSHIYSMHDGVVLGFDHSRMDRPRYTQRFSSPVVRVFDVARPINVESPEAATPLVLLSQPLQPPDPDYGSLDDRDARVFVDCTSAGGWFAMSEETYPLVTGRAKMAQCYEKDYLRHGQPLTSLPTSQQRDALAGVHSLNGPRVVRNTPSISGPSPLELANDTPRELMRSPSELALPPALRHSTIIRKGWDNAVDIFVTILLLFFGAFIYFNSHNIQELAKQKLDVKNIIASYAQPPLSTPSTPVVESTHFKRDSSPSRPISNLTVEVTVPEEQQEGDATPKPKRDRSAVGPDSTPRVKIREPSRGPDSDDDVEELDQAASPEKPKKKARRGRRGGKNHRRGKKPDSEGESKDQADRVVDQVNNLQPQSRLEPDLQLVRTVSNDIIEMDGVLQIGRLRVFSDVVLGHGSHGTVVYRGSFDGRDVAVKRMLVEFYDIASHEVGLLQESDDHNNVIRYFCREQAAGFLYIALELCPASLQDLIERPGDYPQLVQGGLDMPDILRQIIAGVRYLHSLKIVHRDLKPQNILVAMPRGRTGSRSLRLLISDFGLCKKLDDNQSSFRATTAHAAGTSGWRAPELLVDDDNRSAIQGGESQHTESSEPAVVDPQTNRRATRAIDIFSLGCVFYYVLTRGSHPFDKNGKFMREANIVKGNFNLDELQRLGDYAFEADDLIRSMLSLDPRKRLAPLCSSLAFRLFTDLFPRPDASAVLMHPFFWNPSDRLSFLCDVSDHFEFEPRDPPSDALLCLESVACRVMGPEMDFLRLLPKDFKDNLGKQRKYTGSKMLDLLRALRNKRNHYNDMPAHLKAHIGGLPEGYLNFWTVRFPSLLMSCHSVIVELRLTKIDRFKRYFTPVE
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).
Sequence:
MKVLLLKDPKDKESGPDPYVKELGLYGFEATLIPVLSFEFVSLEGLFEKQLSHPECYGGLVFTSPRALEAIKICLRENSKNEAWSKSLKQQWNAKPTYVVGKATASLVEEIGLCPQGEKSGNAEKLAEYICSREGPHSSPLLFPCGALKREVLPTALKEKGIPLESLTVYQTAQHEHLQQSLSSYFSQQGVPASIVFFSPSGVKFCLQHIQKLSGDFANRIKFAAIGPTTAEAMEAAGIPVSCTAESPTPQDLTAGIQKALRPQNCILSE
The following text describes a protein:
Function:
2-oxoglutarate-dependent dioxygenase essential for auxin catabolism and maintenance of auxin homeostasis in reproductive organs. Catalyzes the irreversible oxidation of indole-3-acetic acid (IAA) to the biologically inactive 2-oxoindole-3-acetic acid (OxIAA).
Sequence:
MDLKVPTIDFRNYSEWKKGSEKWNLVRDGVFKALEKYGCFEALLDGEIPKEQLYEKLKQVFNLNLDEKFEKSQNVLVGYTRDNPRTPLQERMMIGNVLTHDAVQNFSYILWPQGDPKFCDLVLGYSKKLLEFDDMVRIMVFEKLGLERYLDDHKKSGDYLLNCMKYKVGEETNVGVPPHTDKIISTILSQHDQHVNGLQILDKNGQWIDLQYSSPHSYMYFVGDCFKAFTNGRFHSSTHRVIMGNEERFSMGFTTIPKQGYIIKVPEELVDEHHPLLYKPFDGSKYLPFYMSGVRRGVVETIESFCGVSPNTQDLS
The following text describes a protein:
Function:
Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism.
Miscellaneous:
MISCELLANEOUS: Present with 450 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSKYQINCIRYRHFLRTSNISQIPDFTKYCIGPVNEELAPYIMETMKAYPSNSEYINPQHYYHNRTVLVENYLKRSPNPVSLTQLAQYYDDSTKLTRTKIINSGKFVKEELVIRIAHKLNQLQQLPFNVVNNFHFVQVYESYYNIFESFRKYPTIRTLEDASQFADFIKNMLEGFNTLNLPHLIMGALECTILDLYPREKMDQLLSDLLRARISRRLIVEEHVSITANYTSGKEENTLVLGDIFQECSAKKYLLEASEESQKFIQDMYFKDIPMPEFIIEGDTQLSFYFLPTHLKYLLGEILRNTYEATMKHYIRKGLEKPEPIIVTVVSNDESYLFRISDKAGGVLHDDENLWSFGKSKERAQESLNNFHKLPGLQTVSIYDEVHSHTKYNSKLKSLQSITLKPYMHTSLEPMSYPSIINGHIKYETPLIELLKRSFRYKLGIGLAMCKVYAEYWNGDLSLHSMPGYGTDVVLKLGNLMKHTKKLQLDKV
The following text describes a protein:
Function:
Putative sodium-dependent amino acid/proton antiporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRSDDHLLKVTSNGEQASTETLSCSQTDMGETSPITTISESTPLINSSTPIKAEHHERHGTILSSIFTLVSTMIGGGVLSLPFAFQQGGFVMSSLVLIFVLMASTHGGFLIINSKKYCQGRIKNVEDVGRIAFGYKGEVLTQLVLIVTLFLCSVAYWILITDQLQPLFFLMCGPNSFWAKKIVVLTIPVLVIFPFTLLKSMSALKFTSFLSVFCVMFLAGGIVHQSVESHIGGRITRPDNPVKWWPKDLGGFLTSVSITGLTFACHFNILPMHSELRYQTRQNKRIILYSAMAITYCLNVVVSFFGFMQFRKYVDQDITKNYPHDNVVLTIGRCALALTLLLSFPLLIFPCRDVINRLIWKEHAPILATDSVSRTMFLISNDTLSGPSRIIWLAETVFLVFFSYVLAYYIPQVAMVWGFVGAIGTTLTIYILPPAFYLRVRLHPSRPDLKQVAAWGLMLVGILVLIVCTYQSFVNVINPIPAVISHATNISVTDSS
The following text describes a protein:
Function:
Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
Subcellular Localization:
Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MSVCSLLVAGGRWRCFPVPLGSSLFQVIPNSYCRKKCTAPKKIIPNAAFCDEDTKDSGNELDKLFSSEQQASILHVLNTASNKELEAFRLLRGRKSVNIIEHREKFGPFQHLESLMNVPLFQYKTAIQVCNSILCPETEGKKRKFQDNRLLRKLIKPEIERERLKAVTSIVSIVFGTRRIAWAHLDRKLAVLDWQQNDCCQLMKGTYLSSVYLQKISSVISKIPTADFYVLEKIGLSIQNTSRFPLLLHFHIMEAMLYALLNKTFAQDGQHRVLSMNRNGVGKHFELMIGDTRTSGKELVKQLLTESVLKEDPRVVFPKEKIVRYRQMFSSTEQKRAEELYDSLLQAVAFYELAVFDTEP
The following text describes a protein:
Function:
Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MLAYVIRRLLLIIPTLLAILIVNFLIVQAAPGGPVEQAIARIQGFSPNGVGGGGGEVAASGTASRSTRGLDPALIEQIKEHYGFDKPMHERLWLMLKNYAQLDFGTSFFRGAPVTELIAQKLPVSLSLGLWATLITYLISIPLGIRKAVRHGSAFDVWSSTLVIIGYATPAFLFAILLIVVFAGGSYLSWFPAQGLLSENFDSLSTWGKVKDYLWHLVLPVSSLVIGGFATLTILTKNSFLNEISRQYVVTARAKGLTEHRVLYGHVFRNAMLLVIAGIPQALIEVFFAGSLLIETIFGLDGLGRMSYEAAVSRDYPIVFGTLFLFTLFGLLIKLIGDLCYTLVDPRIDFSARSA
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MFLRTVVVELLFLGHWRHAEATHAALDEEKIKTLCKIANQLTLTPAIVVSKANQIKKTQEAAQEASQLAQAAAAATSDVNTSTVFQATALQAANCAETAATQYTKLINDAQEVMLNGPKTAGHITEIAHLLLKLSGDNSKWCLGTSSTKTTHTTVAQLGCPGIYVDTPPAATATDPTLVTQTGFFGLAGAANVESSTGYTKCYLLKSGASTIWGKAGPINVKLAADFLGLTAQDSHGSETANLETLNAGATNGKFNPASTGPQKLFNAIHRLNNFELQNCGKTTEEALQLAAADPTTQTLLAQALAARNSYEQANQATSDAQHMLKAAADGKADEIGKKVMENIKQTSTARIENTKQTSKQLKETPTAEQRRQSILLEHMNQRYQILQLSTDLEGEKIKRNAATSKAKLSDDDCKAKTGGACKDGCKEISENGQKKCVVDKKEATKVEGGEKDNKTGTTNITGSNSFVINKAPLWLAVLLLE
The following text describes a protein:
Function:
Non-catalytic subunit of the structure-specific, heterodimeric DNA endonuclease MUS81-EME2 which is involved in the maintenance of genome stability. In the complex, EME2 is required for DNA cleavage, participating in DNA recognition and bending. MUS81-EME2 cleaves 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs. MUS81-EME2 which is active during the replication of DNA is more specifically involved in replication fork processing. Replication forks frequently encounter obstacles to their passage, including DNA base lesions, DNA interstrand cross-links, difficult-to-replicate sequences, transcription bubbles, or tightly bound proteins. One mechanism for the restart of a stalled replication fork involves nucleolytic cleavage mediated by the MUS81-EME2 endonuclease. By acting upon the stalled fork, MUS81-EME2 generates a DNA double-strand break (DSB) that can be repaired by homologous recombination, leading to the restoration of an active fork. MUS81-EME2 could also function in telomere maintenance.
Subcellular Localization:
Nucleus.
Sequence:
MARVGPGRAGVSCQGRGRGRGGSGQRRPPTWEISDSDAEDSAGSEAAARARDPAGERRAAAEALRLLRPEQVLKRLAVCVDTAILEDAGADVLMEALEALGCECRIEPQRPARSLRWTRASPDPCPRSLPPEVWAAGEQELLLLLEPEEFLQGVATLTQISGPTHWVPWISPETTARPHLAVIGLDAYLWSRQHVSRGTQQPESPKVAGAEVAVSWPEVEEALVLLQLWANLDVLLVASWQELSRHVCAVTKALAQYPLKQYRESQAFSFCTAGRWAAGEPVARDGAGLQAAWRRQIRQFSRVSPAVADAVVTAFPSPRLLQQALEACSTERERMGLLADLPVPPSEGGRPRRVGPDLSRRICLFLTTANPDLLLDLGS
The following text describes a protein:
Function:
Galactosidase that is able to hydrolyze the alpha-1,6 disaccharide melibiose and the synthetic p-nitrophenyl alpha-galactoside substrate (pNP-Gal), with retention of the anomeric configuration. Does not hydrolyze DNP-Glc or pNP-Glc.
Sequence:
MKKLTFLLLCVLCTLSLQAQKQFTLASPDGNLKTTITIGDRLTYDITCNGRQILTPSPISMTLDNGTVWGENAKLSGTSRKSVDEMIPSPFYRASELRNHYNGLTLRFKKDWNVEFRAYNDGIAYRFVNQGKKPFRVVTEVSDYCFPSDMTASVPYVKSGKDGDYNSQFFNSFENTYTTDKLSKLNKQRLMFLPLVVDAGDGVKVCITESDLENYPGLYLSASEGANRLSSMHAPYPKRTVQGGHNQLQMLVKEHEDYIAKVDKPRNFPWRIAVVTTTDKDLAATNLSYLLGAPSRMSDLSWIKPGKVAWDWWNDWNLDGVDFVTGVNNPTYKAYIDFASANGIEYVILDEGWAVNLQADLMQVVKEIDLKELVDYAASKNVGIILWAGYHAFERDMENVCRHYAEMGVKGFKVDFMDRDDQEMTAFNYRAAEMCAKYKLILDLHGTHKPAGLNRTYPNVLNFEGVNGLEQMKWSSPSVDQVKYDVMIPFIRQVSGPMDYTQGAMRNASKGNYYPCYSEPMSQGTRCRQLALYVVFESPFNMLCDTPSNYMREPESTAFIAEIPTVWDESIVLDGKMGEYIVTARRKGDVWYVGGITDWSARDIEVDCSFLGDKSYHATLFKDGVNAHRAGRDYKCESFPIKKDGKLKVHLAPGGGFALKIK
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MAPIMSGAAAAAGGTGGAVPLIKNATSASQMSRGKAGTGAGAVVCYSPMMVTAYGIWQGASPLDFSLPLFLLQVAIIVATTRLLVILLKPFRQPRVIAEILAGVILGPSVMGQVSTWAVKVFPERSLLTLETVAHLGLLYFLFLVGLEMDVNTIRRSGKKALIIAVAGMALPFCIGTATSFIFRHQVSKNVHQASFLLFLGVALSVTAFPVLARILAEVKLLNSDLGRIAMSAAIVNDMCAWILLALAIAISEVNSSAFSSLWVLIAGVAFVLACFYVVRPLMWWIVRRVPEGEAIGDVHITLILTGVMVAGVCTDAIGIHSVFGAFVYGLVMPSGPLGVVLIEKLEDFVTGLLLPLFFAISGLRTNVTKVRDPITVGLLVLVFVMASFAKIMGTILIAVSYTMTFRDGVALGFLMNTRGLVEMIVLNIGRDKEVLDDESFAVMVLVSVAMTALVTPVVTTVYRPARRLVGYKRRNLQRSKHDAELRMLACVHTTRNVPSIISLLELSNPTKRSPIFIYALHLVELTGRASNMLAAHHSASNPGGASDHIFNAFESYEEMVGGVSVQALTAVSPYQTMHEDVCVLAEDKHVSLIVLPFHKQQTVDGGMEPINASLRGFNESILASAPCSVGILVDRGLSAAAARMAAVHHVALLFFGGPDDREGLAYAWRMVENPGVCLTIVRLIPPGYTAPAISPPQPPMPAAHSRAINVVPEVAKSERQMDEEYLNEFRSRNLGNDAILYVEQVVANSEETVAAIRSQLDNAHELYIVGRHPGEASSPLTSALAEWMESPELGPIGDLLVSSEFSKMASVLVMQQYVITAPLPPPVALAGPPTDDPVRQYLTNANQRPSVAIGGNQMGAAGRGGWSGGAGGY
The following text describes a protein:
Function:
Regulates the transcription of one or more of the genes involved in virulence.
Sequence:
MVNVDTKLLVIFVELLSKRNATYVAEKMHMTAPAVSHSLGRLREIFDDPLFIRVPHGLTPTPKALELGPKVREMLDLWAAINEGDIATFDPLEAAGTFNISFAGTLGDALFDRFLLRVKRLAPGLQVRLTESSSWEADVAAMRSNELDLAFSPFPTRHPEIVEEVVTSFNMWVCARKDHPVLKDHCSLDQYLECEHIFIAQGNPGTRAAPSLIPLDYALQQRGLKRHSTMTVHAWRTQAEVAAQTDMIFTVNSLMKDLVCETYNLNAFPLPSELETVLGLNMLWHRSRNTHPMLVWARNLFKQVVAEYTGKASIAPMHPPMLTDDSGKSGKTGKGDAEKEDESRLSV
The following text describes a protein:
Function:
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVVLKLGTSVLTAGTDRLHRPRLVDLMRDIAAVSAQGHEVVLVSSGAVTAGWEALGFPPRERTLAEKQLLAAVGQVQLMHLYTSLAELYGLRSAQLLLTADDFRERTRYLNARTTLEGCLSRGVLPVINENDTVAVEQIKVGDNDTLSAFVANLVEADLLLILTDAPGLYTADPRTHPDATLIPVVERVTPDIWALAGGAGSHRGTGGMHTKIQAAEIATRAGTPVVIAPGDLPEALRRVVDGEALGTRFLAHGTRLEARKRWILAEIAHGRLLLDGGAAQAVRERGSSLLPAGIRQVEGDFERGHTVRLLAPDGQELGRGLTRYRADDLRRVCGHHSREIEALLGYTYGEEAVHRDDLVLL
The following text describes a protein:
Function:
Damages membranes of susceptible bacteria. Has no hemolytic activity. Not toxic to mice. Does not inhibit the proteinases elastase and cathepsin G.
Subcellular Localization:
Secreted.
Sequence:
MKPWILLLLAGLLILSTQLTTAKTTKQLRLPKVKPGECPKVKIPPDYPCNQYCVWDFDCEGNKKCCPVGCAKECFPPGPL
The following text describes a protein:
Function:
Catalyzes the first step in the synthesis of phosphocholine by converting phosphoethanolamine into phospho-monomethylethanolamine (N-methylethanolamine phosphate). Phosphocholine is a precursor for phosphatidylcholine, a major component in membranes and a precursor itself in the production of glycoconjugates secreted by parasitic nematodes to avoid host immune responses.
Sequence:
MSTDQQSSVEDQTVAMVNVRRANFKSFWDKYSDKPDTNSMMLNHSAEELESSDRADILASLPLLHNKDVVDIGAGIGRFTTVLAETARWVLSTDFIDSFIKKNQERNAHLGNINYQVGDAVGLKMESNSVDLVFTNWLMMYLSDEETVEFIFNCMRWLRSHGIVHLRESCSEPSTGRSKAKSMHDTANANPTHYRFSSLYINLLRAIRYRDVDNKLWRFNVQWSCSVPTYIKRSNNWRQVHWLAEKVPAEDGAKGTSFNELVELIKNTWQNEQEAWDAKLDDEKYVWTDKVFSSALTSLPSNSTFFLYTPRTVSPYCHINAHTLAETFNANVWNTEIIPEYYRTSLTKSNNLKDQRVRFGWNQSLTDSVTYWQQKDALFDVFVATEFLSTVDDETIRQLPNVMSDGAKFITLEPVDEVNEAEMKQRIQELGYTLKSFTDVTDQCIEAQEQYFKDHEQLRDEKVIRKNWVLLELTH
The following text describes a protein:
Function:
Virulence factor affecting bacterial dissemination and survival within the host. Has magnesium-dependent catalytic activity toward sphingomyelin (SM) and acyl- and alkyl-lysophosphatidylcholine (LPC), but not toward sphingosylphosphorylcholine (SPC) and phosphatidylcholine (PC). Lysophosphatidic acid (LPA), assumed to result from LPC hydrolysis, evokes pathophysiological responses after LPA receptor internalization. Shows hemolytic activity.
Sequence:
MREKVVLFLSIIMAIMLPVGNAAAAPVVHNPASTANRPVYAIAHRVLTTQGVDDAVAIGANALEIDFTAWGRGWWADHDGIPTSAGATAEEIFKHIADKRKQGANITFTWLDIKNPDYCRDARSVCSINALRDLARKYLEPAGVRVLYGFYKTVGGPAWKTITADLRDGEAVALSGPAQDVLNDFARSENKILTKQKIADYGYYNINQGFGNCYGTWNRTCDQLRKSSEARDQGKLGKTFGWTIATGQDARVNDLLGKANVDGLIFGFKITHFYRHADTENSFKAIKRWVDKHSATHHLATVADNPW
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the enzyme membrane arm which is embedded in the lipid bilayer and involved in proton translocation.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MSPVYFSFSSAFILGLMGLAFNRSHLLSALLCLEGMMLSLFIAIALWSMTLNSTSCSITPMILLTFSACEASAGLALLVAATRTHGSDHLQNLNLLQC
The following text describes a protein:
Function:
Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
Sequence:
MHELALAQNIIELLEEQAVNHQFSKVKQVWLEIGVMACVEVPALHFGLDVAARHTLADNARFHITIAPAQGWCLSCNQPFTSQTSTLCCPLCHSGKVQIDDSSRMRIREIEVE
The following text describes a protein:
Function:
Participates in transcription termination.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKVRLTTEEIMKIGFFEKIANVPILDCVLNDERVAFIVKEGDVGAAIGKGGENVKTAEEKFGKKVDIIEYSDDWRKFIRNIFAPIQLDDVWVKRVGKDVVAFIKINPKVRRAVFGEKGKNLERALKILKRHTKITKIKVIVENQKFKRKRAKRPVVKDQQQEQTETKQETDVQQDVKETVKE
The following text describes a protein:
Function:
May play a role in sperm development or sperm function. However, does not appear to have an essential role in spermatogenesis or male fertility.
Subcellular Localization:
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.
Sequence:
MFILLAAWRKTNPLDSVQDRSANTYAEAGVSITITSLTNALAFAVGAITSFPGVRVFCMYSGIAIVFAYLFQLNFFGACMIYDGYREKQNRHFLTCMKVPIISKDDQTSCCQQSCCRGDPNKAGVGQDGKDHNDHLIMLFFKKYYGPFLTNVWVKVVVMIVFLGYLGVAIWGCVQLMEGVQLSKLAGDASYVARFLEQDDRYFSEYDVRVAVVVTEKLDYWDPDVQDRVENMLAEFEDTAFTYGKNVSESWLRDYLAYIDRICSNPMLPPSQQLNLTDKDSFIECLRDRFLNVQGFTKYGHDILFNEDGTEIIASRFFVQTKEIDGTLKEKNMMTKMRELASGASVEAIVYHPAFVYYDQYIAILPNTLQNLGIATGAMLVVSLFLMPHVVNAVWVTLAIASICTGVLGFMTLWSVNLDSVSMIHIIMCIGFSVDFSAHIVYSFVTAKESNRDAIVVHALYSLGVPILQGSISTILGVAALSMAPSYGFRTFFKTVFLFLVIVFGLVHGIVFLPVMLSCWGPQGGAVKVNGNRLSDVARAQNRNENPLMTVSMKLWLDHLKEDNRQRNKGTTESQQNLTANPEMGFSLKPI
The following text describes a protein:
Function:
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs). Also identified in a modified version of SAGA named SALSA or SLIK. The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities. Within the SAGA complex, participates in a subcomplex with SGF11, SGF73 and UBP8 required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket. TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. SUS1 also has a role in mRNP biogenesis and maintenance of genome integrity through preventing RNA-mediated genome instability. Has a role in response to DNA damage induced by methyl methane sulfonate (MMS) and replication arrest induced by hydroxyurea. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies.
Subcellular Localization:
Nucleus, nucleoplasm. Cytoplasm, P-body. Note=The nucleoplasm localization requires the presence of UBP8 and SGF11 to bind part of SUS1 to the SAGA complex.
Sequence:
MTMDTAQLKSQIQQYLVESGNYELISNELKARLLQEGWVDKVKDLTKSEMNINESTNFTQILSTVEPKALEMVSDSTRETVLKQIREFLEEIVDTQ
The following text describes a protein:
Function:
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
Subcellular Localization:
Nucleus.
Sequence:
MASITCSNRHVAIASGSKVKVISYSDPSQVVVFDLKGKPKEMAEKTSEKQKEEKKAEEETAAGIAGVPTGRVLATAFSRSGAHFAACTDDKELTIWSTDPSWKKLWTRTVVKRCMAVTFDSSETALYVADKAGDVYRFEIGDENKEHTLILGHVSMLLDVVVSPDDNLIMTAERDEKIRVSHLPNAYNIHTFCMGHTEFISRLAMLGSDHLISCAGDSTMIMWDYREGKELCRTSFEWARPSTEERGQKNEATVTCISCSKEHSLVAVTVLDHSTVPIYHIKTEKDGRRTFQEVTRIECKHPPWSVTFDPSGRLLVLLPDPEAPLLVFAVETNDDDGVLQVSEDLSSEGSAALLAQQVQQDWEFLKCSCDVLSVFKGLHKVPFDNMSDYLQRKQERMDNDQTKKGPRRRARRWNKSKKRPIEGATGNGDAAKRTMLDEEEDDEEGEEDVDEEIEAVEANS
The following text describes a protein:
Function:
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of cichorine, a phytotoxin active against knapweed, corn, and soybeans.
Subcellular Localization:
Nucleus.
Sequence:
MVGSRHPDQCAKRWHHSLDPNVKRGPWTMEEDSSLLEAVQKIGRDWKEIGRELFPSRSTTDIKNRYVILSRRRGPSPAIPENCSSIDIETHSSSLADSKPPIPAELLTPEVDFSIANTPCELDSSNLAPDTLSINMTLPSDLPSYLSLPLPDTAETDHALDESSTAWEIPDWTAFDNQCLFTPGASELEGSFTSRNHEEPPQPLPVPDIPGPSTLVLEDLRPETVNLVIDTLLRTNSKFGMRMYNTGS
The following text describes a protein:
Function:
Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity).
Domain:
Atypical domain architecture: contains 2 receiver domains.
Sequence:
MEGSKRDIIENSNNGNNKGVVIEELGETYYTNSKPSTSADCKYFRDSFEFGSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNEEKSNNETEKTLESNGDTTTTTTTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNSSNDIYMNSPSSTLSSPGNAGNNLPIGCTKPNVPKSPYSPSPPHLYKSNSTSYLKSSFFSGNGSSSSSSSTTTTNINSNNSNTNTYSTSTNVKKNNSNTNSNTNNNTNGNTNTNSNSNKKNINSNSSDNIIINDTADIMNRRRDRFKSFSWTIGESNSNSKFSELSMISSKCKSIKSEFTPLFETLTVFDESDKIRHSLIQNHYKTLLIQNPASPNRTLLTNLLQRRGHNLTTCPIDINHVLQLLQKESFSLFIFDPNESIINNTSNSISSNEPISLSSSSSYYNNNNSNNNSVNNNNNNNSGNSTNNNSPSSHTPNSPMIFQPIVSNICSNSGGSGNNSPHHIDNNNNSNQQQQQQQQQQQQQQQHQHQQQQQQSSSTTATTNNSCTLNQQQQQQQQQQQQQQQQQQQQQQSQPTTPTQSTQSPTTSISFSKKKNLTINTSFKTSPMSSPKSFNKPSQSPQNIFNNFSNTYNPNNIEFCKILKSKLTEFETVIVLTESTDPSEFCQYIDAGATDYIPQPISPILLDLRLTTCQKLVNNNLHLKKAESLKDATRKMVTCIENSPDCVEIWDPSGHIQYLNLAFSEMTGFARWELLGKEFSNLIDNTEIIPNMWATLTDKKTWNGFIRTRHNNNTLIYFEASISPVLDQFQQILYYNCTKRDVTQKRIDEESKTLEQNKIIEKSRLRLSMMSHDIRTPMSNIIGMADLLLDTSLSQHQHHYLEIIKNSSNTLLTIINDILDISKIEAGKLDIDYESFDFNATVSQVVESMAQRVQSKGLELLSYVDPKIPNILIGPSSRLNQILTNLLGNSLKFTDKGEISICCLLNDETDSEYEIKVDVRDTGIGIKKEALPLLFKAFTQAEGTITRQYGGSGLGLAICKELVHLAFNGEISVESQYGHGSTFTCILKFKKFLPSDSQNLLPASSPLQQQQQQQQHQQQTQFHQHQQQTQFHQHQQQQLQHQQHQQHQQLQQQQQQQQQLQQQLQQHQQHQLQQRQHHQQQLQQQQHHHHQQVHLQQQQQHEHDAQHNQHIQQQQQQQQQQQQQQQQHEHNNNGHHNSHGHNHHGSHHNHNHQHNNNNNNITINKLQHQEKKQKSNEQQLESITENSFSPIVEPMVISDPDTPEALNISQSPSPQSIHNGTTINQQPTSPLNTLGSKFDFSGAKMLFIERNDTSRGNLFKQLLAWNIQLELVEDGESGFRKWKQSIESNSPYSIIIMDLNTPGVDGASLPMRIKKELELMQQHLQQQQEQEQQQQQEQQQSELQKQPDVENKNSSQNNDNNNNNNKSNSSGGNQCIYRSPIIMLMPIQFLNSQLEDNLKDAGVCAILSKPIRMSQLADVFMMYLGPNSEHNNNNNYNNNNGNGYLNGGGGGGGSVNGTGNGTLQVGMSNDGGNGCGVVSFWNKQRRASAEEQEQDPSKLLGKVLVVDDNHINIQILSKMLQTVGCEVDSVLSGADALAKINQSSGDSYDAIFLDIQMPDMDGFQVSRKIREREKKFSLPRVAIIATTANVFKEDQLKCFDAGMDDFISKPIKRAEIKEIIKKYGKNGNHQSGSAYSLYKLS
The following text describes a protein:
Function:
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May be involved in the organogenesis of the spleen and heart and in cardiac and coronary artery development. May function in the development and sex differentiation of gonad via transcriptional regulation of AD4BP/SF-1.
Subcellular Localization:
Nucleus.
Sequence:
MSTGSLSDVEDLQEVEMLDCDSLKVDSNKEFGTSNESTEEGSNCENGSPQKGRGGLGKRRKAPTKKSPLSGVSQEGKQVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDTKLSKLDTLRLASSYIAHLRQILANDKYENGYIHPVNLTWPFMVAGKPENDLKEVVTANRLCGTTAS