lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MAICKPTLFNQFGLTLYGADSIFGLNVGSCQLSQFKHPTAACLSSSATTGVPTDHFDICIVGAGIIGTAAACAMAQSPYSSGKRIALIEAGDLFKSPVLMPGQFANRVSSITRGSALFLDQIGVWDRILVKHPYTKMHVWDASSDGVMAFDADSSQVDLKPHGEPAIGWIVQNHLIQASLAQIVSQTPSITIFNSSTVTDISADALSGVPTVVLNNGHQFSCQLLVGADGMNSKVREFAGIESIGWDYNMHGLVATLQVDDSASDNDTAWQRFLPTGPIAMLPLAKGYASLVWSTTPHLASLFKKMSDAHFVEFVNCAFHNPLQDLQFACDQLHPDGSIDDSVNLKDEIAWGLERSSGSGSESGESRKALRVIGVQPYSRAPFPLRLRNSTSYTSTRTALVGDAAHTIHPLAGQGLNLGLADAQSLCKAIEQGSQHGSDVGSSSVCEAYGRDRFAKGVGMLAAVDGVARAFGGMIPSALRSTGMNLINSSSVVKKTIMNLAS
The following text describes a protein:
Function:
Brassicaceae-specific phytocytokine (plant endogenous peptide released into the apoplast) perceived by MIK2 in a BAK1/SERK3 and SERK4 coreceptors-dependent manner, that modulates various physiological and antimicrobial processes including growth prevention and reactive oxygen species (ROS) response regulation. Inhibits root growth and regulates root meristems. Prevents general growth and development. Exhibits antibacterial effects against Pseudomonas syringae pv. tomato DC3000, Ralstonia solanacearum, Bacillus subtilis and Agrobacterium tumefaciens, thus being an antimicrobial peptide (AMP).
Subcellular Localization:
Cell membrane. Secreted, extracellular space, apoplast. Note=The precursor of SCOOP14, PROSCOOP14, accumulates at the plasma membrane and is proteolytically cleaved to release the SCOOP14 in the apoplasm.
Sequence:
MAAKTSNLVALLLSLFLLLLSISSQVGLGEAKRNLRNNLRLDCVSHPSPPPPHRSMAPPIFVPPSTSHKGQGP
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MLSITDLSIRLAGRLLIDQSSVQITPGSRVGMVGRNGTGKSTLFKVIRGELAAEHGAVTLPPRWRVGSLAQEAPNGPESLISVVLKADLERDALLHEAESATDPHRIAEIQTRLVDIDAHSAPSRAAAILSGLGFSAADQLRPCAEFSGGWRMRVALAATLFAAPDLLLLDEPTNYLDLEGTLWLEDHLAHYPRTVIVISHDRDLLESSVDQILHLERGKLTLYKGTYSSFEEQRAARELLDAKAVKRQEAERARLQAFVDRFKAKASKARQAQSRVKMLERLKPITALVTEDVREISFPAPEKILSPPIIAVDNASVGYDPATPVLGRVTLRIDNDDRIALLGANGNGKSTLVKLLAGRLAPFSGKVTRADKLSIAYFAQHQLDELNEDASAYDHVRKLMGDAPEAKVRARAGAIGFSGKAADTKVAKLSGGEKARLLLGIATFFGPNMIILDEPTNHLDIDSRAALAEAINEFPGAVIMVSHDRYLIEACADRLWIVADRTVTNYDGDLDEYRRLVLSARNSEPAPRERSTAAEKPQRPKSDNRGSLRKRITEAEAEIARVSDIITKIDTALALPDIFTRDPKQAAQLSKARANAADALARAEEQWLEASTQFDEAAG
The following text describes a protein:
Function:
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
Subcellular Localization:
Mitochondrion.
Sequence:
MFARQFIRFASYDSTRKNLKLTKASKLICQGFTGKQATFHCERALEYGTLLVGGVTPGKGGKKHLGLPVFNTVKEARDALKPDVSIIYVPPFAATKALHEALEAEIPLIVCITEGIPQHDMVKFRYRLSRQDKSRLVGPNCPGIIAPEQCKVGIMPAMIHKRGCIGIVSRSGTLTYEAVNQTTKHGLGQTLVVGIGGDPYNGTNFIDCLDIFLKDPDTKGIILIGEIGGCAEEEAAEFLKKNNTGDKRKPVVSYIAGLSAPPGRRMGHAGAIISGGKGGAPEKMAALRNAGVIIANSPALMGDHLKTEMDNKIMMVTAPSEGTLDEVITKNIAGLDRNINLQKQTPLQKLRKRLRRRILVDTLIFVIVALLVCLVEFGIIPNTKLGFTCKDPKLSYPFKGDTVSVTTLLISAYFGPILIITLVEVLKEHSFKKVRLGTVWNYYRECLIGATFVLLITEVIKVIVGEPRPHFLDSCEPDVKCKEGAFIVEYNCTNTRLSNFFLSDITRSFPSGHTSVSLFIALYCSYLIQIRIPSKSVSTLTKPFLIAVCLTWCLLCSLSRITDRRHHWWDVLGGAFLGLCGALYTLSLLHSKETKEKNRLSRTSTSMTIMSEKSKDTPSVVI
The following text describes a protein:
Function:
Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRSPGWWSMDPVAAHSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSGQKNDVFHLDIKNVSGIGQILDFMYTSHLDLNQDNIQVMLDTAQCLQVQNVLSLCHTFLKSATIDQPPGLPCHGTFSLQSTLTPDTNCVLSENYPPHLLPECSAGAQQCRAVDGSLSHAPPSVGLHPPTAETSKQAPDPFDGSCTELPFKQPNCYYKLRNLYSKQYYKHASCPSHERVTEQPFTFSASADLHAEDRRPYAVGHTECVLESSQHLPSNFLAQPLGENAPDPASDHAGQQPTRQMRLKKAIHLKKLNFLKSQKSAEQTSEPKPNDSLTMRLEAAREHSVEKVNSPSAEEKESEELSNSENFNGVSETERPEDPAALEDQTQLPQSQRQYACELCGKPFKHPSNLELHRRSHTGEKPFECNICGKHFSQAGNLQTHLRRHSGEKPYICEICGKRFAASGDVQRHIIIHSGEKPHLCDICGRGFSNFSNLKEHKKTHTADKVFTCDECGKSFNMQRKLVKHRIRHTGERPYSCSACGKCFGGSGDLRRHVRTHTGEKPYTCDVCNKCFTRSAVLRRHKKTHCRASDEGPGALEALARAIEAPDLERSQSSDSFSQDVSVPLMPAVTVKIPAHPVDENSVAGFDSPCKFQPVAQPQHGPSESEKLSLEPVKLAKPPHVPLAQHQAYGYPDVDAPAGAEPLQADGVAALRSSLAALDHPPCTDPLGSRAAAPAYRNSEGQFFSSMTLWGLAMKTLQNESELDQ
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MTPQATALLALALTAEQARGNIPAGANEQEFGALCAIVDLSRSDITINQFPDQTAALEGAVLALNMSLADESWQKRFSKDGAKKEWIKELPAGTADPGHWKKSWPKWAAAAARLADQGTAAEIKSSGFETLNPIERAGAKASVAQIAAEAQFLTQQIAEKENVGKKHTAATVKAALNEAIYGVKQEAPPDFEPTRNYDGLNTQAREAICVGLGSEAKTTTIAGAIYCICGQDNAQAEKVCARNQADTHKWTSITNAMTKDGFEEIVKHCAGPAKTHLTSSLLMGLITKIKNLIRRVGANAYMGALKTGSSCNGDKTQGICIKYAGYDGTPTKDFAAIPWAQKLLALHDDLRQQEKAIAEATALEQQLAVAKNKAYAAALLQKTAPPTAGQTSSDNVNRKGDQGTQPTNKCNQIVTEETCNKENECSYEKESDGTKRCKYNATKATANGVPVTQPQKGPAKTTENKCKWKPEKDFKSPDCKWDGKECKNSSIIANKQFAMIVSAFVAMVF
The following text describes a protein:
Function:
Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of KdpE in response to environmental signals such as low levels of potassium ion, osmotic imbalance, acid and nutrient stresses. In turn, KdpE binds to the upstream promoter regions of target genes to positively regulate their expression.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTLLFADLCAIFTPYRWMIEHVTTKRGQLRIYLGAAPGVGKTYAMLGEAHRRLERGTDVVAAVVETHGRNKTAKLLEGIEMIPPRYVEYRGARFPELDVEAVLRRHPQVVLVDELAHTNTPGSKNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQITGIEQKEKIPDEIVRAADQVELVDITPEALRRRLAHGNVYAAERVDAALSNYFRTGNLTALREIALLWLADQVDAALEKYRADKKITATWEARERVVVAVTGGPESETLVRRASRIASKSSAELMVVHVIRGDGLAGVSAPQLGRVRELATSLGATMHTVVGDDVPTALLDFAREMNATQLVVGTSRRSRWARLFDEGIGARTVQEPGGIDVHMVTHPAASRASGWSRVSPRERHIASWLAALVVPSVICAITVAWLDRFMGIGGESALFFIGVLIVALLGGVAPAALSALLSGMLLNYFLTEPRYTWTIAEPDAAVTEFVLLAMAVAVAVLVDGAASRTREARRASQEAELLALFAGSVLRGADLATLLQRVRETYSQRAVTMLRVRQGASTGETVACVGTNPCRDVDSADTAIEVGDDEFWMLMAGRKLAARDRRVLTAVATQAAGLVKQRELAEEAGQAEAIARADELRRSLLSAVSHDLRTPLAAAKVAVSSLRTEDVAFSPEDTAELLATIEESIDQLTALVANLLDSSRLAAGVIRPQLRRAYLEEAVQRALVSIGKGATGFYRSGIDRVKVDVGDAVAMADAGLLERVLANLIDNALRYAPDCVVRVNAGRVRERVLINVIDEGPGVPRGTEEQLFAPFQRPGDHDNTTGVGLGMSVARGFVEAMGGTISATDTPGGGLTVVIDLAAPEDRP
The following text describes a protein:
Function:
Seems to be able to hydrolyze ADP, UDP and GDP. Supports mig-17 glycosylation and surface expression, which is required for proper migration of distal tip cells during gonad morphogenesis.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MRVSLRFTILAVSAMIFFPVIVFIYVVEAHTSPKVIADDQERSYGVICDAGSTGTRLFVYNWISTSDSELIQIEPVIYDNKPVMKKISPGLSTFGTKPAQAAEYLRPLMELAERHIPEEKRPYTPVFIFATAGMRLIPDEQKEAVLKNLRNKLPKITSMQVLKEHIRIIEGKWEGIYSWIAVNYALGKFNKTATLDFPGTSPAHARQKTVGMIDMGGASAQIAFELPDTDSFSSINVENINLGCREDDSLFKYKLFVTTFLGYGVNEGIRKYEHMLLSKLKDQNGTVIQDDCMPLNLHKTVTLENGENFVRRGTGNWNTCSNEVKKLLNPESSSEVCKAEAAKCYFGAVPAPSIPLSNIEMYGFSEYWYSTHDVLGLGGQYDAENIAKKTQQYCSKRWSTIQAESKKQLYPRADEERLRTQCFKSAWITSVLHDGFSVDKTHNKFQSVSTIAGQEVQWALGAMIYHMRFFPLRDSSRNLIVKETHSSSESLWAPLFFLSAVFCLFVLVCAKEQSVLCFDDKRRSSFGMSRSQYSYKMLKENRTSSSFLENFA
The following text describes a protein:
Function:
Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses. Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication. Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis. However, it has also been shown to have a pro-apoptotic activity. Modulates innate immune response mediated by RIGI by preventing its activation.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MRQKAVSLFLCYLLLFTCSGVEAGKKKCSESSDSGSGFWKALTFMAVGGGLAVAGLPALGFTGAGIAANSVAASLMSWSAILNGGGVPAGGLVATLQSLGAGGSSVITGNIGALMGYATHKYLDSEEDEE
The following text describes a protein:
Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120 (By similarity). Has activity towards EA2, MUC2 and MUC5. Probably glycosylates fibronectin in vivo (By similarity). Glycosylates FGF23 (By similarity).
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Resides preferentially in the trans and medial parts of the Golgi stack.
Domain:
There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding; The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity). Essential for glycosylation of FGF23 (By similarity).
Sequence:
MAHLKRLVKLHIKRHYHRKFWKLGAVIFFFLVVLILMQREVSVQYSKEESKMERNLKNKNKMLDFMLEAVNNIKDAMPKMQIGAPIKENIDVRERPCLQGYYTAAELKPVFDRPPQDSNAPGASGKPFKITHLSPEEQKEKERGETKHCFNAFASDRISLHRDLGPDTRPPECIEQKFKRCPPLPTTSVIIVFHNEAWSTLLRTVHSVLYSSPAILLKEIILVDDASVDDYLHEKLEEYIKQFSIVKIVRQQERKGLITARLLGAAVATAETLTFLDAHCECFYGWLEPLLARIAENYTAVVSPDIASIDLNTFEFNKPSPYGSNHNRGNFDWSLSFGWESLPDHEKQRRKDETYPIKTPTFAGGLFSISKKYFEHIGSYDEEMEIWGGENIEMSFRVWQCGGQLEIMPCSVVGHVFRSKSPHTFPKGTQVIARNQVRLAEVWMDEYKEIFYRRNTDAAKIVKQKSFGDLSKRFEIKKRLQCKNFTWYLNTIYPEAYVPDLNPVISGYIKSVGQPLCLDVGENNQGGKPLILYTCHGLGGNQYFEYSAQREIRHNIQKELCLHATQGVVQLKACVYKGHRTIAPGEQIWEIRKDQLLYNPLFKMCLSSNGEHPNLVPCDATDLLQKWIFSQND
The following text describes a protein:
Function:
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MEPILALLLALGPFQLSRGQSFQVNPPEPEVAVAMGTSLQINCSMSCDKDIARVHWHGLDTNLGNVQTLPGSRVLSVRGMLSDTGTRVCVGSCGSRSFQHSVKILVYAFPDQLEVTPEFLVPGRDQVVSCTAHNIWPAGPDSLSFALLRGEQSLEGAQALETEQEEEMQETEGTPLFQVTQRWLLPSLGTPALPALYCQVTMQLPKLVLTHRRKIPVLQSQTSPEPPSTTSAKPYILTSSHTTKAVSTGLSSVALPSTPLSSEGPCYPEIHQNPEADWELLCEASCGSGVTVHWTLAPGDLAAYHKREAGAQAWLSVLPLGPIPEGWFQCRMDPGGQVTSLYVTGQVIPNPSSMVALWIGSLVLGLLALAFLAYCLWKRYRPGPLPDSSSCTLL
The following text describes a protein:
Function:
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. Involved in the STUB1-mediated proteasomal degradation of ESR1 in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAQRGGARRPRGDRERLGYRVRALRPGREPRQSEPPAQLGPPPSRRPPARSTASGHDRPTRGAAAGARRPRMKKKTRRRSTRSEELTRSEELTLSEEATWSEEATQSEEATQGEEMNRSQEVTRDEESTQSEEVTREEMAAAGLTVTVTHSNEKHDLHVTPQQGSSEPVVQDLAQVVEEVIGVPQSFQKLIFKGKSLKEMETPLSALGIQDGCRVMLIGKKNSSQEEVELKKLKHLEKSVEKIADQLEELNKELTGIQQGFLPKDLQAEALCKLDRRVKATIEQFMKILEEIDTLILPENFKDSRLKRKGLVKKVQAFLAECDTVEQNICQETERLQSINFALAE
The following text describes a protein:
Function:
Involved in T-cell adhesion processes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MARAAMEAAATVVLALALLGAAARGAASDDFNLGDALEDPNMKPTPKAPTPKKPSGGFDLEDALPGGGGGGAGEKPGNRPQPDPKPPRPHGDSGGISDSDLADAAGQGGGGAGRRGSGDEGGHGGAGGAEPEGTPQGLVPGVVAAVVAAVAGAVSSFVAYQRRRLCFREGGSAPV
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDKSDSLLQSSSKGLRSSIFFQGSSRILTFFLNQLTIRLTSPSAYAFSSIHFEILQSTILFLSRESVRLAMQRIPSENAIITSTSTESNKSKKLSDQLQLIKNTSLISVYIGIVISLLVSLFYFYSLPNFPYSKTCIFIYTVSSFIELLSEPYYEVLQWRQKFSKTASAEGLGTIICSLLSFAISVLGRNKAPSSLPFALGNLSEKVTIFFTLRYFAKQPFSIFLHKVGENERYIFWDSSTLRIICSHTYQVLLKHLITKGDKIMVAWYASPSAQGPYALASNYGSLLARIVFRPVEDHSHIVFAQLTHYKNKKDEKKALNLLAWILKLYSYMSLFILFGSNYSDIVLLFGAGSKWASPDSSSILSWYAMYIPFMAANGVLEAFYVSAANSSQLYDQGKCYLASAVFYFITGKFLLSWFNLGSHGLILANILNLSLRICFALRFILHNYKDFSLPRSLPRPFLLALSILLSIISSFLVKHWRESKVPFLVYFLSAPSLAILYSCFIILVDKDVRGYAKILLSKYYIK
The following text describes a protein:
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization. Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner. Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration. Also mediates ubiquitination and degradation of IL-33-induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis. Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation. In addition, plays a critical role in the recruitment of RNF20 to histone H2B leading to H2B mono-ubiquitination.
Sequence:
MSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFSLSLMECTICNEIVHPGCLKMGKAEGVINSEIPNCWECPRCTQEGRTSKVKGGRERHLKKKPKPPIASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAIRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCVCMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSASGLKRDLVLMIVEVLFGSTARTVAEAINDYGPCPLGFISSRTNISVSDVQTVCLAMYVHGVVNIHGEGKRATLTLATLPLFILAAPSILLEEIRTAYAKQELLDVLYIYLLQGICTVEQGAKYFHQNETRTANEFQGTDESNSVNSFEKFDEVTKELFNLGFLCRGIRSYHPFTSQDVISLERRINNLQLNQKRVTKAQQQKEEEAMAVQNRTLPQQEEIPTDAYSVDWNACAQFIRARYIINYVNKAFGPDYGIIIDKVVTNAHCCNYVHFRKMAEHSDDQLRNEGLPYSRLSGTDIYRQFSDIPATVFFERLDKLSNPSTKSIFGLLTSAEDGTVYDFKVHNCIRKIQLMYVNSFAETALCPMHGRIFETLQDLEIADTRQLEDEAIVSDKEARCAMYNLCRMGLTQIQAIPKTADRMLKEMYFVWKYNEDSVIAEAANNIGKVALNMWDKITSCIEEADHVAHADSLDKTATMAKSQEDKNLAGFHSYFIDQMRLYVLLAEM
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
MAAVAPSADQAADLLQKLSLDSQNKSLEIAEPKKKPVYSKDVGNGQIQPVDRSVTPLLPDFMDPTLCYVPNGYPSYYYEAADLLQKLSLDSQNKTLEIAEPKKKPVDSKDVGNGQIQPVDRSVTPLFPDFMDPTLCYVPNGYPSYYYGYDGSGNEWEDYTRYVNPEGVEMTGAYGDNGSFMYQHGYGYAPYSPYSPATSPVPTVGHDGQLYGAQHYHYPYFQPLPPTSTPYTTPVAPPKGEIATSAAADQAPLSVDSANGNSNGIANGGVKGNTAPTPVRMVGPVDFNKSVEYWQQDKWIGCFPVKWHIVKDVPNSLLKHITLENNENKPVTNSRDTQEVKMEQGLQVIEIFKDHISKQCILDDFEFYEDRQKRIQEKKAKQQLFQKQSHVWEGKATEEKNKDNSNGQLKSHKLSEVSAVLSKESSPAAQSNGEVKLVENGSITKLGDDVKVAKLVTVSDKKPVAKGIANGAVN
The following text describes a protein:
Function:
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.
Subcellular Localization:
Nucleus.
Sequence:
MAAAADSFSGGPAGVRLPRSPPLKVLAEQLRRDAEGGPGAWRLSRAAVGRGPLDLAAVWMQGRVVMADRGEARLRDPSGDFSVRGLERVPRGRPCLVPGKYVMVMGVVQACSPEPCLQAVKMTDLSDNPIHESMWELEVEDLHRNIP
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MSKKSILNDLIAATEADLSLAKSVSASSKKARLFSEQLEVLRSVQKGLGGPLIFKVADLKKYVDTKSLGVLETRWGKVLDKRRKAREEAEEEKRQQEETAARERERIKQSAQDAVVREHEELVEKIRREKGKAGRGTSGFTDPLHGTDSSIATVDLTDAVDLTDDAPPQQMAVATASTFYPKQGTAAHDLLVALVGIPNPTTKEQVLNITGPGKTWGGLSKLKSEGLVTTSKMNSTYTYSLTPAGKDLANKLRRFSTQEKRVGQELREEIERQKRPKTAKRVDIQGFSDKSKLASSQQVTKLNRYSADEDMDVHVVPMSDGATMAAAELRHSGVVRPITEAAEVTWEPSSYEVVLIVDKRENNREEAQQAISGLSQKNVTVVPSVLYLGDFLFAARHKTSKKIAVLNTIIERKRYDDLNSSIVDSRYEEQKSRLRKCGVENVVYLVEHFSMSRAAVQIRDKAIASILGRVVAIDGFLLKKTKSVADSCDYMASLYESVKMCYEGVTLSIGPKEIGGFSKSRDTFSTMMLTAWQDKNLKSNHSLKVLFIQMLMTINGISAEKAQVIQKLFPTPRHLIDKYRDLEESHGKGYLELLTRGQVKGVGKAASEMVWEVFGKL
The following text describes a protein:
Function:
Transcription factor that modulates the balance between cellular proliferation and differentiation in root growth. Does not act through cytokinin and auxin signaling, but by repressing peroxidase expression in the elongation zone.
Subcellular Localization:
Nucleus.
Sequence:
MGVTLEGQRKESIWVLMRRQRARRALVKKIMIRPRKSVEASRRPCRAIHRRVKTLKELVPNTKTSEGLDGLFRQTADYILALEMKVKVMQTMVQVLTETNCV
The following text describes a protein:
Function:
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
Sequence:
MGSESSGTAELPPLPQVGIGTDIHAFEDGRELWCAGLKWEGEGTGLAGHSDADVVAHAACNALFSAAGAGDLGQHFGTGRPEWSGASGVTLLAEAARIVRARGFRIGNVAVQVVGARPKIGKRRDEAEAVLSAAVGAPVSVSGATTDGLGFPGRGEGLMAVATALVVRGA
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex.
Subcellular Localization:
Nucleus. Cytoplasm. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MSALCDPPGAPGPPGPAPATHGPAPLSAQELSQEIKAFLTGVDPILGHQLSAREHARCGLLLLRSLPPARAAVLDHLRGVFDESVRAHLAALEESPVAGPPHLRPPPPSHVPTGGPGLEDVVHEVQQVLCEFIRANPKAWAPVISAWSIDLMGQLSSTYSGQHQRVPHATGSLNELLQLWMGCRATRTLMDIYVQCLSALIGSCPDACVDALLDTSVQHSPHFDWVVAHIGSSFPGTIISRVLSCGLKDFCVHSGAGGGASACGNSSQPPSTDPFPGSPAIPGEKRVPKIASVVGILGHLASRHGDSIRRELLRMFHDSLAGGSGGRNGEPSLQATVPFLLQLAVMSPALLGTVSGELVDCLKPPAVLSQLQQHLQGFPREELDNMLNLAVHLVSQASGTGAYRLLQFLVDTAMPASVITTQGLAVPDTVREACDRLIQLLLLHLQKLVHHRGGSPGEGVLGPPPPPRPVPFLDALRNHVGELCGETLRLERKRFLWQHQLLGLLSVYTRPSCGPEALGHLLSRARSPEELSLATQLYAGLVVSLSGLLPLAFRSCLARVHAGTLQPPFTARFLRNLALLVGWEQQGGEGPSALGARFGESASAHLADLAPLLLHPEEEVAEAAASLLAICPFPSEALSPSQLLGLVRAGVHHFFSSLRLHGPPGVASASQLLTRLSQTSPAGLKAVLQLLVEGALHRGNTELFGGEMDGDNETLSIVSTPLASASLLDINRRHTAAVPGPGGIWSVFHAGVIGRGLKPPKIVQSRNHQEVIYNTQSLVSLLVHCCSASGNSEREGCWGAPTLSPEAAKAVAVTLVESVCPDAAGAELAWPPEDHARATVERDLRIGRRFREQPLLFELLKLVAAAPPALCYCSVLLRGLLAALLSHWEASRHPDTTHSPWHLEASCILVAVMAEGSLLPPALGNMHEVFSQLAPFEVRLLLLSVWGFLREHGPLPQKFIFQSERGRFIRDFAREGGAEGGPHLSVLHSVLHRNIDRLGLFSGRFQAPPPSTLLRQGT