lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mitochondrial inner membrane insertase that mediates the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the inner membrane. Links mitoribosomes with the inner membrane. Forms pores capable of accommodating translocating protein segments. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the N-terminal part of the COX2 protein into the mitochondrial intermembrane space.
Miscellaneous:
MISCELLANEOUS: Present with 6550 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein. Note=The availability of nuclear- and mitochondrial-encoded substrates influences the inner- membrane distribution.
Sequence:
MFKLTSRLVTSRFAASSRLATARTIVLPRPHPSWISFQAKRFNSTGPNANDVSEIQTQLPSIDELTSSAPSLSASTSDLIANTTQTVGELSSHIGYLNSIGLAQTWYWPSDIIQHVLEAVHVYSGLPWWGTIAATTILIRCLMFPLYVKSSDTVARNSHIKPELDALNNKLMSTTDLQQGQLVAMQRKKLLSSHGIKNRWLAAPMLQIPIALGFFNALRHMANYPVDGFANQGVAWFTDLTQADPYLGLQVITAAVFISFTRLGGETGAQQFSSPMKRLFTILPIISIPATMNLSSAVVLYFAFNGAFSVLQTMILRNKWVRSKLKITEVAKPRTPIAGASPTENMGIFQSLKHNIQKARDQAERRQLMQDNEKKLQESFKEKRQNSKIKIVHKSNFINNKK
The following text describes a protein:
Function:
Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Nucleus.
Sequence:
MSRVKAKTPSLCTCELLTKEIVSKSLSGLREIVASCYGPSGRLKQLHNGVGGSICTTSSSSLLFNNLSVTHPILKILTTSVQNHVSHFSDCGLFTAILCCHLIENFQRLNLSSATVIKVSNHLLSLCTDYLNSETCGCRISVDFSNMKTLHCLVQSILTSKPACLLNKKEADHISTLILKAFLLTIPEKTNDFAILGKSLIIPLKGERVMDSTVLPGIVIEMPEVQLMTFPIKKLPSNALKVALFCISMSGEISDSGEGTLIVTYGVSLENAVVDQLLKLGNQLISDHVDIVVCQKVIHPVLKQYLHQHHIVTIDRVGISLMEPLCEMTGTQPIGSLNFISPTSYGYVKDLCYTNFGSKPYFHLIPNDSTVCSLLLCNRNETSWNELKLTCQTAQHVLKLMIREPLALLGGGCTETHLAFFLSHKVISVPECVLKANDCTQTEYKIVANAFCNALQAVACSLEHDKGKILADRKYGHFWSVQPDFPPNVKWQDLVSKCGCGLCSNKEELNWCLLQSIHSASQNSPLQQPTNSLKDHLTLDCFTAKLHGLQVAVETASLILDLSYVIEDKN
The following text describes a protein:
Function:
Removes the phosphate from trehalose 6-phosphate (Tre6P) to produce free trehalose. Also catalyzes the dephosphorylation of glucose-6-phosphate (Glu6P) and 2-deoxyglucose-6-phosphate (2dGlu6P).
Sequence:
MTEPLTETPELSAKYAWFFDLDGTLAEIKPHPDQVVVPDNILQGLQLLATASDGALALISGRSMVELDALAKPYRFPLAGVHGAERRDINGKTHIVHLPDAIARDISVQLHTVIAQYPGAELEAKGMAFALHYRQAPQHEDALMTLAQRITQIWPQMALQQGKCVVEIKPRGTSKGEAIAAFMQEAPFIGRTPVFLGDDLTDESGFAVVNRLGGMSVKIGTGATQASWRLAGVPDVWSWLEMITTALQQKRENNRSDDYESFSRSI
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MAAKDIPEATFIEDIDAFMVTQNGASPDAIMQDFATLNQKYSMIESQIAGRRAAHMKRLPEMKKTFEAVKMLQKQRWFRRDGVCNVELTLGAIAQDEEAKRETIFPLAEGVLARATVPPSGTVMLWLGAQVMLEYEIDEAHDLLKAQVEGLESSIATAADTLDFLKNQITTVQVNLARLYNWQVIKNREKKASAATASDDA
The following text describes a protein:
Function:
Structural component of ciliary and flagellar microtubules.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.
Sequence:
MLRNSVITPTPPAKNLASFVTKPTTDIMGYHDNTTRLSNRIDDIETWRETLEKTLADVDEEIRKLEEDKDLAERALEAKALPLDVASECKTLRDGRRDNDVVDDLANSEVGKEIDVIEGIKDALQAKVSSAFEQLCLLQEARQQLHADLRDKTEAKKIDTYCHDLTISSPDICYQPNSTRTPKGSTTPQTWEDFSRYNKDRADAEMRSSQRLREAIHSTVAQTDNDLEAQRQATEFALRKRIHEMKRAKDEDEWQKKNTEEEIAKQERNIRELEQAIKDKENPLKLAMTRLENRTYRPNVELCRDNAQYGLVNEVHEIQDSIKALEKKLQDAHNARDACEKQLYRINKDLELKNNSLDLDNKCMQVREKLTTGPVTQTMNNLSTFKTDRELYTAQRSLLA
The following text describes a protein:
Function:
Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
SGAGAGRRGDARAGLQLPAGRRAESARRGRRALGALEASEASEASEASEALAALADAKLCVGAGPLSAGGRAASVAAAPPRARSVLVKFIIGARGCGVPVEDREDPYSCRLLNITNPVLNQEIEAFGLPEETPAEDREDRVVSVSFRVLYPIVITSLGVFYDAGEAGFQRNITVRLYQAEQEEALLSARFSPPSCGVQVNRLWYKPVEQFILPESFEGVIVWESQDLHGLVSKNLHTVTVNDGGGVLRVNTAGEGSLPHEFLEGVEGVAGGFIYTIQDGDALLRNLHTRPERFLRHVAGLREEDALLRAESAAYDDIVFVDIVDTYRNVPAKLLNFYRWTVRTASFDLLLKTDDDCYVDLEAAFNRIARKDLRRPNLWWGNFRLNWAVDRTGKWQELEYPSPAYPAFACGSGYVISRDIVQWLAGNAERLKTYQGEDVSMGIWMAALGPKRFQDSLWLCEKTCEPGMLSSPQYSPRELAELWRLKESCGDPCRCGAG
The following text describes a protein:
Function:
Required for assembly of cytochrome c oxidase (complex IV).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MSQDSVMPKIDVNKELNGSAQLNYMKLMEKENMERVRKLKRIRHRNLLTGLLLTGGVFSIYAYSMFAVKQENFLDDLDEPLPK
The following text describes a protein:
Function:
Binds covalently through a thioester bond to the pathogen surface resulting in pathogen clearance.
Sequence:
MRRADAFAVSLCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTETVELATAGEFKQITFKLPPLEAGEYNLTAEGVKGLEFKNSTKLNWENFKPYIKIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVSVRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRGNILETKRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIKAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPDYNIQGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAPVVRKNFAETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGITQYQNRAFFINLKDTGEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEHILAKGYEFLLTRQAENGSFTEHGEYFYSSQRSLLTLTANSLLALLEEEKPNQAAIDKAVAYLSANTAESIELLPKSIAIYALQKAKAPEAAKQVASLKSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFKIQTTVLPESSPANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATECYSIKSKLCDICEGDDCKSKC
The following text describes a protein:
Function:
Hydrolyzes ribosome-free peptidyl-tRNAs (with 1 or more amino acids incorporated), which drop off the ribosome during protein synthesis, or as a result of ribosome stalling; Catalyzes the release of premature peptidyl moieties from peptidyl-tRNA molecules trapped in stalled 50S ribosomal subunits, and thus maintains levels of free tRNAs and 50S ribosomes.
Subcellular Localization:
Cytoplasm.
Sequence:
MVKLVVGIGNPGRQYVWTRHNIGFLLLDSLASRFLGAFREAPRLYASFAKVEISSEAVVLMKPTTYVNLTGKAVLAAKKFFDVSMEDILVVADDINREFGFVRFRQDCGSGGHNGIKNTTQILQSNHYWQLRLGVGRPSYPGAEGVADYVLSSFSLNEKEKLNDFLEKGIEEILPWLGC
The following text describes a protein:
Function:
May be involved in microtubule nucleation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm.
Sequence:
MKQNQPNLNVNLNNRLQQQQLNQVAQQQLQQQPLKNTKQNPINNQTNGILNNKPITTSSNIMNSDNILNNNNNNNTNKPSSTFNFNITNTPPPPVNKQKPITSSSTSKPSNTTTTTTTTTTTTKPPSNSLPSSSSSKVKVNSLTSQNNNNNNSNTNTNMTTQPPTFNNLIKPQSLPSTTGMNEIKNTPTRTTTTTSTQHTKYIKEDIVVKENNNRISNMNNNNISGASGGTTFNSYNYLPNNTLDNFINNSNTTTTTTNNNTNNNNNNNNNNNIINNIKQQHELELLQQKHIEEMKILQNEQLNQLKKQQKKLNESDTDGSDDDDDDDDEYGENMNLSPRTLRELKNIQRLKNLEKFSPPYLITKKTSPSIKTLPKFPEWTKERPFLNYGYLANISTNYTSLILPSKYEQTKIQLSSIPNYFREQILIEDLLSTMIGIEGECIHIGVVQENEDDSLQSNLVSFVVEGEVDPSNNDLVQRILPLCSYYSFVNDFIQIRYAYEWGIINHSLCFSIDQLLKEYLVLVSQLEGQLKSERLSLQRMWFYLQPTIKTFEILYRVTSEIMRCNSHGVQVINLLLKLQSKYSSDKKTDDLFHYLIKATTLPFLEMLDLWIHQGIIRDTYFEFMIEENTDLKRDNINRDFNDLYWEQRYQIRQDQIPKYLQSHALKILTTGKYLNVVRECNQSISQQQQHNKSDNNNNNNNNVKLNSQQQLLLLKLNTTQQQQQQQLSSTSASMIPTTIIEYSKNENVYIDKIEKAYDYASGILLNLLINERHLISRLKAIKHYFLLCKGDFFSHFMDTTYDELKKPLDQINMVKMNSLLQLSLRTSSISEEDEFKDDLECEFIPYKLVDQLLNIININNFNNPTTTTTTNTSSNNITATTNTSSNNTTINTTVNTTLIQSTSAHEVLKTNKLFGIESLAFNYNVGWPLSLIISRKSLIKYQIIFRHLFLCKHVEKVLVDTWSQHQFRRSSYNKPGLSTLLSFTHLLRHRMIHFLQNLEYYMMLEVLEPNWNKMKNSIKTSKTVDDVIRIHNDFLETCLTECMLTDTKLVNILMKFMSLCITFANFTNEMMQDEKNIDTEQIKKTISSSENKFHAILKVLMDTLKSFSKTESNRHMIHLIHRLDYNGYYSHYFENNPNLFKNKTSSSSNKSNNVSPPLEPRFSYQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKQNQIQQQKQNQIQQQQQQSRGSTLPSNFSFQTALQQQINTTSATTTTSNQSPHTLIDDLKKRAYGILDSNNTKKTLERTSSSPALDNQSNSLPMTQSISQYAEKLKNLRAVIKNDELK
The following text describes a protein:
Function:
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
Sequence:
MKAAQSSGVHLSRSRLVVVVVVVVLLMVGTGLAVGLTVKHTASTYGQDYQVQSQAISPSPLAMTANRTSPLTTHVLDTSLGRPAAEVPIKLYRTGERLGEEWSQVSSGQTNSDGRCNNLLNTLEAGVYKITFDTATYFNKNGIRQYFYPYVDIVFEVQDPNQHYHVPLLLNPFGYSTYRGS
The following text describes a protein:
Function:
Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Also acts as a ligand for CMKLR2. Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2. Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link Exhibits an antimicrobial function in the skin (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MKYLLISLALWLGMVGIHGTELELSETQRRGLQVALEEFHKHPPVQWAFQEIGVDNANDMVFSAGTFVRLEFKLQQTSCFKKDWKNPECKIKANGRKRKCLACIKLDPRGKVLGRMVHCPILKQGLQQELQESQCNRITQAGEDPRSHFFPGQFAFSRALKHK
The following text describes a protein:
Function:
Plays a role in cuticle biogenesis. In complex with tsp-15 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MWWFGGNPSPSDYPNAAIPNFNMHAFVIFSVFLIPLIAYILILPGVRRKRVVTTVTYVLMLAVGGALIASLIYPCWASGSQMIYTQFRGHSNERILAKIGVEIGLQKVNVTLKFERLLSSNDVLPGSDMTELYYNEGFDISGISSMAEALHHGLENGLPYPMLSVLEYFSLNQDSFDWGRHYRVAGHYTHAAIWFAFACWCLSVVLMLFLPHNAYKSILATGISCLIACLVYLLLSPCELRIAFTGENFERVDLTATFSFCFYLIFAIGILCVLCGLGLGICEHWRIYTLSTFLDASLDEHVGPKWKKLPTGGPALQGVQIGAYGTNTTNSSRDKNDISSDKTAGSSGFQSRTSTCQSSASSASLRSQSSIETVHDEAELERTHVHFLQEPCSSSST
The following text describes a protein:
Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Subcellular Localization:
Nucleus.
Sequence:
TNLYIDIRDNQWPIVYSDRYDISFFGVEKLHPFDSCKWGKVMAILKSMKLIGDDDIVIPNEATENDLLVVHPSSYLKSLKWSITVANIIEVPFVALLPNFVVQKRILKAFRYQTGGTVLAGKLALERGWAINIGGGFHHCSSDNGGGFCAYADITICLKMLFQHVDGVRKAVIIDLDAHQGNGHERDFAYNSNVYILDLYNADIYPRDKDARRGISKEIKIRTGEKDDRYLMLIKLNYPTILDEFKPDIVIYNAGTDILDGDPLGGLCISAQGVIKRDEIVFKETRFRNIPIVMLTSGGYQKSNAKIIADSIMNLYQKKLIGNEYTATFSSGKSVMRPSSVMILQKLHCNRLFHHYFRSESRKTVSKGIHLGIS
The following text describes a protein:
Function:
Catalyzes the last step of the oxidative degradation of choline to glycine. Converts sarcosine into glycine.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MQPCSAVVLGAQQLHVAPCDPLRVCTDKWGIIHRAQPVPYAVTRPGAAFPEALTGASISSPQLAPALRPRRGKAAPDTSSILSSFFLFAAADIISHISWTGQGAALSKHSTGTGCTCWLPSANSSVPRALLADPEHALSLGGLWPASTWPPPSATPQQAALRATRGGNPEPENKGPNSSANGETEPLSPVGCEPPQPCCPLSAGRRAGKRSHSSIPFRISPFCPTLPLSGGATRRTGAGGRRCGRGGGGGGGGEHRRKADVPRPSRASLVDMSYVSCALRVAALCRLPAPWRSPRPYSSATGPTAEKSVPYQKTLKEESNGSTGPSQPPPASAEVVVVGGGSLGCQTTYHLAKLGITNVVLLERDRLTAGTTWHTAGLLWQLRPSDVEVELLAHTRDVVSRDLPAETGLHTGWVQNGGLFIASNKQRLDEYKRLMSLGKVYGVESHVLTPAQTKELYPLMNVDDLYGTLYVPKDGTMDPAGTCSTLARAAAARGATIIENCPVTGIQVRTDDFGVKRVHAVETAHGTIQTPCVVNCAGVWARALGRLAGVHVPLVAMHHAYVVTERIEGIQNMPNVRDHDASVYLRLQGDALSVGGYESNPIFWEEVSEKFAFSLFDLDWDVFMQHIQGAINRVPVLERTGIKSTVCGPESFTADHKPLMGEAPEVRGFFLGCGFNSAGMMLGGGCGKELAHWIIHGRPEKDMYGYDIRRFHCSLTDNNRWIRERSHESYAKNYSVVFPHDEPLAGRNMRKDPLHQELLQQGCVFQERHGWERPGWFSPGGAAPVLDYDYYGAYSQEQHRDYTYNQLLADEYTFDFPPHHNIIKKECLTCRNALALFNMSYFGKFYLVGPEATKAANWLFSADVSKAPGSTVYTCMLNKRGGVESDLTVSRISPGDPSSPLAPAFQGDGYYLAIGGAVAQHNWSHITAVLQDMKLQCKLIDCSEELGMMSLQGPLSRTVLQELLDTDLSNEAFPFSTHRLVKAAGCTVRAMRLSFVGELGWELHVPREDCVRVYQAVMEAGARHGITNAGYRAIDSLSIEKGYRHWHADLRPDDTPLEAGLAFTCKLKSSIPFLGWEAVEAQKSAGIFRRLVCFTTDEKVPMFGLEAIWRDGEVVGHIRRADFGFAIDKTIAYGYIRDPAGGPVSLDFVRSGNYELERMGVRYPAQAHTKSPFDPDNKRVKGIY
The following text describes a protein:
Function:
Thiol-disulfide oxidoreductase probably involved in the redox regulation of a number of cytosolic enzymes. Possesses insulin disulfide bonds reducing activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAEEGQVIGCHTNDVWTVQLDKAKESNKLIVIDFTASWCPPCRMIAPIFNDLAKKFMSSAIFFKVDVDELQSVAKEFGVEAMPTFVFIKAGEVVDKLVGANKEDLQAKIVKHTGVTTA
The following text describes a protein:
Function:
Putative sodium-dependent amino acid/proton antiporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKKFIDGYQAVDNKTSSSQESTRLFYHVESEEHVSMDDIYRRRSSSDTSSIQGYQNIVDASEIMEMKSIPINDAGDGNYDDHSLLLKIDNHKENDKSGIALSSFNIMNTILATGILGIPYALKQAGFVMGLIILLLVAAISDFTALLLIKSGRLASQSSYQNLARAAFGNMGYYLALVCQFLFPFLGIDDFLNMFSRLSAGSSYPYVDIETANLSHHNCYTMPWFDSPETPHAWQFATLNIPQAIGITAFGMA
The following text describes a protein:
Function:
Putative adenovirus Bcl-2 homolog that inhibits apoptosis induced by TNF or FAS pathways, as well as p53-mediated apoptosis. Without E1B 19K function, virus production is compromised because of premature death of host cell. Interacts with Bax protein in cell lysates (By similarity).
Subcellular Localization:
Host cell membrane. Host nucleus envelope. Host nucleus lamina. Note=Associated with the plasma and nuclear membranes, and with the insoluble nuclear lamina.
Sequence:
MEAWECLEDFSAVRNLLEQSSNSTSWFWRFLWGSSQAKLVCRIKEDYKWEFEELLKSCGELFDSLNLGHQALFQEKVIKTLDFSTPGRAAAAVAFLSFIKDKWSEETHLSGGYLLDFLAMHLWRAVVRHKNRLLLLSSVRPAIIPTEEQQQEEARRRRRQEQSPWNPRAGLDPRE
The following text describes a protein:
Function:
Required for efficient splicing and pre-mRNA nuclear retention. May also be involved in positioning the proximal bud pole signal.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MALHQYLSETYGPTKPKNKTKKKKKESKSDANSDKTSLIVKERLSTLQQEQEKSGVASFSKFDKQKSKNIWKNLETNELSHAITHPSASSITGNESKNDLKEIRAQEPLVTVADKSKTRKTIYRDAQGHKIQEDSKIDDSSFSRSKYEDEKAAEREQYLKNLNMGDVQKLGINVDAHDKKKNQTASSLTIEDPAITFTHDKERTVKTSLLGRKLYDKPAPENRFAIMPGSRWDGVHRSNGFEEKWFAKQNEINEKKVQSYTLQEDY
The following text describes a protein:
Function:
Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.
Subcellular Localization:
Nucleus.
Sequence:
MAEPRSPLGIYMAQQQYAASNAVMTPPSSDVNHSEGRPALKRQKSVTSPAVAPPGYVVIQPYDATYKNFPSKRKETSYHYRGRTISSPEGSMELLRKCMQKHINNTLVEAIKPYKELFEKGAQNCRDNCGEEVDPDRLVRTAIRHSLEQCGKEMYGPLDVSLGSSSASMFRKAKRSLSSSDGGAPVNQVVRFKRRKGRPRIYKPVFSERSYGSRSVKQEPVRKEGPKWDPERLTTETKFIMGSRANRAMGLGATRGRLYYKHPDLFKYSSDTEDKQWLFERRHMPATGGKVVGRQIGKYLFSSM
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Nucleus.
Sequence:
MDALVNQYMAATGNAAGIADLITTDQAKLVDLVQLLGEYLVDESAKTRQTAIQCISDVLKDLPTDKLTKQQLTVICEFLSERLADEPVTGQVLDGMNAVVTMSAISSLSVKKIVDSLVGYYLPSSHVQVVRYKAYVLLRYLTENKSQSLKSTASAQEGFIKCFLTCTNGEKDPRNLLESFAINEWISNNLTVPENDVEPQFDATFCYFPITFRPPKNDPYKITADQLKVALRTALAAGKQYSKLIFPALLEKLTSSSLSVKGDTLDTIAACIANYGPEITAENWKDIWDGTKFEVLHGSEPELAGKTLTVLKRLAEELQKHGDQSQLDEYLTNVETDCMDKLKDPTNRLSTQAAQIVASVSLAGVDVAKKLTTPALSAILAVTDTQIPTLTSICEILLIFLKSSLPNVTSTPLFEFKDRVFDVLAKALLSSPESESSLRILAIKGFSAAVNITEFLSQTDTELIVRYLDDVIVNDTNTKTLQAAVDALVLIAEKPGNAGIIQNITFPALLSELPASDSDKEAKTRILFLLSVLAKVSTSKTLIEVLQVRILSHMDTVTGSTALYPTLLLQTLLSALKEQESKDNFDTTSYLKSTFPRLFKTAFDASYSGSPAVMATPQVTEAAGRILTSITRHCTVQDQVLTSLFSLFFNGTTSDIFPSATLPEKQKFNVLDTPLPCMSLLTSCFAPLSRDLELPKLHDPFVLLRSVISTVSGTADPAIRRHYLRFAGLLTNKWINTAASPQAVAFVTDLLETATLDALESAAWIIKGWLLKNDSTAFKFVDTLVGMLPGANGLVAAKSFDILLGDDELFVKQNSVVIRQLYKQRLFVSVVPKLVQGYKDVDDKVPYVVALSNIVNSVPSSIVSPALESIMSLVVDSLSVSEARVKTAGIDTILATIGQTDIVASYLDELVPSLLDAAFSSPAVSIKALQCLGAFASTVDLPKIVPFKQRIINSLTPLLDHKKRDVRRACVDTRQAYFELGINK
The following text describes a protein:
Function:
Plays a role in the regulation of membrane potential.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNSEKIIEVIIAIFLPPVAVFMKCGATTPLWINLVLCIFIWFPAILHALYVVLKD
The following text describes a protein:
Function:
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
MVHPALPKVTAYLGELSNASLDYFPGSILQGIQAIHVGKGIIECKLIIEDRVLGEDGTIHTGAIAAIMENIGATAIFSAGGSDHASVDFNYSLYSTAKKQDEVKIEARVIGRKDDLTSAVIEIRRECDEELIATGRLWMVQRRSLNVKHNGVDLPSKL
The following text describes a protein:
Function:
GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.
Sequence:
MPHAARKKVLLMGKSGSGKTSMRSVIFSNFSAKDTRRLGATIDVEQSAVRFLGGLVLNLWDCGGQSAFVDNYLSSQKDTIFSNVAVLIYVFDNTTSEWESDITYFEEILLALRENSPDAGVWCLINKMDLIDKEDPKRKRYNERKEELMRVNEKVEKEVEERGREITCFPTSIWDESLYKAWSSIIHTLIPNISLITSHLTYLRDLCLCVEAVMFEAETFLVIAKSGSPLDCDPSDLDAVEAKAGGKDLDRQRFEKISEIIKGFRKVCQRNHERYQGFQAKFDACTVVLEPLSKNTFILLVSNDPRIETGAMLYNIHRAQTHVAEFGVGKIVLERKCGICKRDPKAKYECKEEDDPSVPAWDAVDKEDAPLMQPSIGTR
The following text describes a protein:
Function:
May be involved in the synthesis of minor phospholipids and in modulation of IP3-mediated signal transduction.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNKLRRRKQSNEIPSEITKPNGGNLLANDRNKYKSMWIRTHSTFWMIGAFVLLIYMGHLYICAMVISIQILMAKELFNLLRKVREDRDLPGFRLLNWHFFFTAVLFVYGRFLSQRLVNTVTSDKVLYKFVSILLKYQMVICYFLYIAGFVWFILSLKKKMYKYQFGQFAWTHMILIVVFTQSSFTVANIFEGMFWFLLPASLIVINDIAAYLFGFFFGKTPLIKLSPKKTWEGFIGASVTTIISAFLIANVMGRFEWLTCPRKDLSTGWLHCDPGPLFKPDYYHLPGSIASWIPWKEIPIMPVQWHALCLGLFSSIIAPFGGFFASGFKRAFKIKDFGDSIPGHGGITDRMDCQMVMAVFAYIYHQSFVKSQSFSVETILDQILMNLTFEEQLDLYRKLGEILQQKRFG
The following text describes a protein:
Function:
Final receptor of the SLN1-YPD1-SSK1 two-component regulatory system, which controls activity of the HOG1 pathway in response to changes in the osmolarity of the extracellular environment. Under normal osmotic conditions, maintained in a phosphorylated and inactive state by the phosphorelay intermediate protein YPD1. Under conditions of high osmolarity, the histidine kinase SLN1 is no longer active and the unphosphorylated form of SSK1 interacts with and activates SSK2 and SSK22, two MAPKKKs that further stimulate the PBS2-HOG1 MAPKK-MAPK cascade. Unphosphorylated SSK1 is subsequently degraded by the UBC7-dependent ubiquitin-proteasome system to down-regulate the HOG1 pathway after completion of the osmotic adaptation.
Miscellaneous:
MISCELLANEOUS: Present with 1200 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MLNSALLWKVWLRIDNSTDEVNQPIAVQFDEIDTVDDLKSRFFQKLSSTRWREINDNASIAIGLYAPKFDNQADNTSSNNTNDNSCRSKSNGAGSGANLSVNSNTKSSVSPTAGSFGLSKDLAKDRNVLQHPKPTQKRGALYDAFAAVPTVAATTNVDFPPNEAPMLSPQRPYSTSPKQFPATTKSPLLRFASVSPYPKFHSDNQIMASAGLTYVSPHNKNKYTRPLIRKGLNFTTESVNDCTYKIIFEPDELAINIYKELFGTMGSQPASQPLLIFSNVNLRQDVPPLDILNVVDYVPTNEEISQQKTQPTDHGAVGVFHLDDHISPGEQGLKQTIGDKADLKGKDGNSSPQEFKLITDEEQLRRASQELKDEEKDAESPWQAILLLPKGYKGGVDFRNKPVAHTDSSFNNEDTITHSELEVNTGSPSQESGSLNEAGIGITQPMSEVQRRKEDVTPASPILTSSQTPHYSNSLYNAPFAVSSPPDPLPNLFTTTSEKVFPKINVLIVEDNVINQAILGSFLRKHKISYKLAKNGQEAVNIWKEGGLHLIFMDLQLPVLSGIEAAKQIRDFEKQNGIGIQKSLNNSHSNLEKGTSKRFSQAPVIIVALTASNSQMDKRKALLSGCNDYLTKPVNLHWLSKKITEWGCMQALIDFDSWKQGESRMTDSVLVKSPQKPIAPSNPHSFKQATSMTPTHSPVRKNSNLSPTQIEL
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MVGLHWKALRRGWAKLNSDDSALPNPMKLQVEGNSSINEKDRFSTPLMVEQQLFPSLISDSETGDGHGSITPTYVCEICVEPKPLDISFNIKGCSHFYCIECTVKYIKSKLDDNVSRIQCPVTDYEGVLDPDFYREILPRDLFNRWGKALCESALLGSEKLYFPYKDCSALLVNDGEKRIKRFPCPPCKRVFCVQCKVAWHSGADCIKFQKLKNLGSDAMLVDLAKRKKWRQCPNCSIFVEKSAGCCYVKCRSVFYFF
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MGHLFLLLLALLLTASAHASTHGHGKAAFAEDKSIVGVIGVIGSRPPSCAGRCRSCGHCEAVQVPISPQELQKKKKLGHGSRAAAAAAAAAAATGGRTMPASYDDHSNYKPLSWRCKCGRLILDP
The following text describes a protein:
Function:
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Subcellular Localization:
Cytoplasm.
Sequence:
MPDFSATVGAKTCETWLRRLPPDDPVSLYIHVPFCRAICWYCGFPTSLTRSERPIRKYLATLHAEIRLVAEQAPRALPVSDVHFGGGTPTTIAPADFLALMALLRRCFAFSKSATIAIEIDPRAFTAEMVETLQVAGVNRASIGVQSFDGVVQRSVNRVQSEVQTASVVESLRQHGISRINFDLLFGLPHQTVRSCVDSTRTALAMRPDRLAVFGYAHVPSYMKRQRQIDETALPDNLARAEQAAAIADTLVSAGYRQIGLDHFALPNDELALAQKAGQLRRNSLGYSADTCKTVIGLGPSAIGRLREGYVQNESATASYHQHIQAGRPATSKGYCLSPEDRLRAAIIERLMCDLQADVPAICAAHGFDPIPLLNSADRLGMLAEDGIVDIEEGFIRVKQEHRFLVRAVAAAFDTYLDRIPIN