lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the degradation of glucose via the semi-phosphorylative Entner-Doudoroff pathway. Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG).
Sequence:
MLEVVTAGEPLVALVPQEPGHLRGKRLLEVYVGGAEVNVAVALARLGVKVGFVGRVGEDELGAMVEERLRAEGVDLTHFRRAPGFTGLYLREYLPLGQGRVFYYRKGSAGSALAPGAFDPDYLEGVRFLHLSGITPALSPEARAFSLWAMEEAKRRGVRVSLDVNYRQTLWSPEEARGFLERALPGVDLLFLSEEEAELLFGRVEEALRALSAPEVVLKRGAKGAWAFVDGRRVEGSAFAVEAVDPVGAGDAFAAGYLAGAVWGLPVEERLRLANLLGASVAASRGDHEGAPYREDLEVLLKATQTFMR
The following text describes a protein:
Function:
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
Sequence:
MLQPKRTKFRKMHKGRNRGLAAGADVSFGSFGLKAVGRGRLTARQIEAARRAMTRAVKRQGKIWIRVFPDKPITEKPLAVRMGKGKGNVEYWVALIQPGKVLYEMDGVPEELAREAFKLAAAKLPIKTTFVTKTVM
The following text describes a protein:
Function:
Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Associated with kinetochores.
Sequence:
MARKHTFPSLKRAEILECIDGLGIPFTAKELDQPTSKAVIPLYEEFLDLFMGLTRQNLEEKVNSLQDSVENFEIIHESLRFTVFYQILSQFMQNICFHDFTIQDLLKPDRNRLQLILSAVINFAKLREERLQQFDDDIQKRESLLETYTLLDAQRKDLEEKVLLSQDRKLESEAIIKQNEERNEEMFQSLIEDKRLCSQVRTEYDRIRMEASELKIRYHNVDSLMASTLEEIEKLQSSIVHSPEKLKGKIADTSLRIQNDRSQQVELDKKSKILHTKLNSLQLIEGDLNACLKVLEECLVELDKLEHATVLLSTNQELCDQIEINKKKLEFRKEQLLKQLSNAQEKLEHEQHSRNQKLEAAKQRMDNIREEYKVITQERNKKIQETEKKNAMIEMTEQKIAGMREELESQISSITMEFEKLKSHVELYIAELLRNLRSSNS
The following text describes a protein:
Function:
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.
Subcellular Localization:
Secreted.
Sequence:
MRILEIFAILLILKEVRPQTKRSHKVNMKTPFQKRKNHHLNTDSRATLMSPADLHSVEHSIVQIRDPTLIPHYDQKSQEDMKLHFLKNTLVTCNDGTTAGYYLRETKGSKRWIIFLEGGWCCYSKETCGVRYDNVKRLMSSSNWPQTRKGTGILSPRQDENPYWWNVNAVFVPYCSSDVWSGNVSKTQDGYAFMGSVIIQEVIRDLVPRGMKQAKSVILAGSSAGGTGVLINIDRVAALVEETTSESVQVRGLVDSGWFLDSRHSKQSDCLDISKCALTEAIKKGLKLWNGILPENCKQQFKKGDEWRCFYGPRLFTSMKSPIFVVQWLYDQEQLRIENIQTEFQSMTENQWNSIQNIGREFKKSLREVPAVFAPACLSHTLITKSNWLEFQVKSVTLAKALHCWDRSLQENRAPKGVIRGCPFHLVDNCQWPHCNPTCPAIYDATSGQELSILQMFLKLRLESQRRGQEPKGDLGPLMSMLRNSG
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.
Subcellular Localization:
Nucleus.
Sequence:
MNGSKQSVPENKWLSPGARNSDEEDVITRRQSQRKRPKVEYREMDEKLAQLTEDELSPEFSDASINEDDQYGEIPEGMEGAAFRSRLPHDQITPQEMNCFPDIAQNNSLKSTFLYIRNRLLELWLNNPKVELTIEAAIPQFQAPYNNNRHLITRLHGYLTRYGLINFGIYRLLKRPTSTKTTVLIVGAGASGLIAARQLQSFGIDVIVIEGRNRVGGRINTFSKGSWVADLGAMVITGLGGNPIDILSKQISMELSRIKQDCPLYETSGKMSYSSLVPKDKDNMVETEFNRLLEATSYMSHQIDFNSVDDKPISLGEALELMIKLRERQVKEDLIQHYKRINELQDQCLAVKRQLITVQTDIVQIHREHVGVDAKKQPSSIDNEFQARSKARELVSLFKEHDSLLSKQQEIQQKLSLLESNPPSDVYLSPRDCQILNWHFANLEFANACPLKRLSLKYWDQDDDFEFSGAHLIVKNGYSCVPEALADGLNIKLNTTVRNINYNERGVEIITQSNYESGGSDNTTTKFCGDAVLMTVPLGIYKYNPSLIQFNPPLPEWKTNGIKRLGYGNLNKVVLCFESIFWNSKSNLFGHVNSCTSDRGELFLFWSTKRSPVLIALIAGEAAEAIENISDDTIVARTVAILKGIFGANNVPQPKETCISRWFSDPFSKGSYSYVGVHASGADYDIMASPVSPNASTTANRTPLGTVEKGPNQPRVFFAGEHTCRNYPATVHGAILSGLREAGRITDQFIGQPYAPEDSNV
The following text describes a protein:
Function:
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Subcellular Localization:
Nucleus.
Sequence:
MSDAAADTSSEIIAKDLKEKKEVVKEAENGRDAPANGNANEENGEQEADNEVDEEGEESGEEEEEEKEGGGEEEDGDEDEEAESATGKRAEDRDYSTPWSMA
The following text describes a protein:
Function:
DNA-binding transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription. Promotes thermotolerance by transiently regulating a subset of genes. Induces expression of STI, SSA1, SSA2, HSP78 and KAR2 during the heat response.
Subcellular Localization:
Nucleus.
Sequence:
MTTNLYAIAGPSKPTTPTSTPSPRSEPPSPLKSLTSLPTNPLNPQGTSTSNALTNQSSSTGIGISKPGLSVDENGEVMKVPAFLNKLYTMVSDPEVDDLIYWGENGDSFFVPNAELFGRELLPRWFKHSNFSSFVRQLNMYGFHKVPHLQSGALKNETPIELWEFANPYFKRGQPQLLTKVTRKNNRLSNSGVGSSSSLGGSGAGGGMNTRSASAAAASGSGSGQIQQAISQGHEAGNHSTSGKYLITDGTTPGSAPPSHTSAGPLIAPQTLDLSAINSGIAAIRQTQASIATDLRKLQASNEALWRQAYETQEKQRKHEETIDLIVSFLERLFGTEGEGLKGLKEAMRRGVGVRRDRDGREGRDSRDARFADDDDGGQKKRRRVGLDRMIEGGSGDGTGEHGEIESPSSDDRLVEIGSNSEYSIPSVKRTSSSSHPLSLGQLGSSRFTALPSEDPSPSGSGLGSTPYEGLRTTQASAHGAGADVNVTDPTLGMNHLSPLSDTDPLLPSSSNALAPYTSHPSFPSSNPNPSSAWAFNPSQPLLSPTSAVAAAHAYNLDPSLLQTTIGSLLQSPAVAQMFLKSLSASAQGQALTSHSHPHNPSLLNPNPNGNASTSASASAHDMNTEGLGTGSGTKDLDPTLALFSPLPSHSSLASQSNDLLKSYNDALTVGEGVDNLQESIDSLVRSMGLDLPNGGSSSVGVDVGDGSGVGTGTGEGDGEFNVDEFLQGLAKEGEGEEGEREVGGDGDASSSGAGAENGRKEDVIAQSGLK
The following text describes a protein:
Function:
Has bactericidal activity.
Subcellular Localization:
Secreted.
Sequence:
MRIHYLLFSFLLVLLSPLSAFSKKVYNAVSCMTNGGICWLKCSGTFREIGSCGTRQLKCCKKK
The following text describes a protein:
Function:
It may be a growth factor/hormone, perhaps involved in interaction between the maternal and fetal systems in maintenance of pregnancy.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MTPTIFLVILCLGVASAVIVPEAQLDAELQEQKDKEVLIKAVWSKFMKTNKLHSSENDQETEGSNIEMSASGQLTDEELMKIMTTVLHPMFEEEENKPQPVVDDPEFEDYTESGDGFFVPNQPQ
The following text describes a protein:
Function:
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MGDKRGLVLDETATYGTVDRLTGWFRNVCIQLPEGTLLVLCCCAVEQRIGVTTFSIGLSYDLLTGLDPSNPDTVQSPWILTLQVDQKEEYPKGLLLRIPTKQTLKDYWIHQLKEACVSRDGNANRVMSLSNANSQKMWDSLVSHDFKTFWSIMTTILPREKDSGAIRSLPIKVYLPMSNQCIAAIVKPETDDGKLTTIGQSLHSHLPTFFPSETKPVVARAVVHGVEVPLNAVLANLYYMAMYPDGFLHISLVMIN
The following text describes a protein:
Function:
As a component of the decapping complex, involved in the degradation of mRNAs. Essential for postembryonic development, especially during the formation of the shoot (SAM) and root apical meristems. Required for normal patterning of internal tissues of leaves.
Subcellular Localization:
Cytoplasm, P-body.
Sequence:
MASSPGNTNPHNTPPFDLGILFKPSSNPYPPPAASYPPPTGPFLHNQYDQQHYAPPGISAQPSPVTQQQQDVSSSSAATNLHPQRTLSYPTPPLNLQSPRSNHNPGTHILALLNNTNNGAPVANQEPSHQLPVVNHNEIARSFPGGSGPIRVPSCKLPKGRRLIGEHAVYDVDVRLQGEIQPQLEVTPITKYGSDPQLVVGRQIAVNKVYICYGLKGGNIRVLNINTALRSLFRGHSQRVTDMAFFAEDVDMLASVSLDGKVFVWKISEGSEGEDQPQITGKIVLALQILGEEDTKHPRVCWHCHKQEILVVSIGKHVLRIDTTKVGRGEVFSAEAPLQCPLDKLIDGVQIVGKHDGEVTDLSMCQWMTTRLVSSSVDGTIKIWQDRKAQPLVVLRPHDGHPVSSATFVTSPERPDHIILITGGPLNREMKIWVSAGEEGWLLPADAESWRCTQTLDLKSSTEPRAEEAFFNQVIALSEAGLLLLANAKRNALYAVHLDYGSSPVGTRMDYLSEFTVTMPILSFIGTNDPPEEPIVKVYCVQTLAIQQYTLDLCLCLPPPIENMGLEKSDSSVSREANLVEGMSEPSGLKPTDLPSVDSVPKPSIIVNRSESANKLSFPSAEATSQAIVPPNGEPKTSGLPSQTSGAGSAYATLPQLPLSPRLSSKLSGYHTPVEAIEPVIPHHELGGKTPSADYSVDRQMDAVGERNLDVSSVEEISRSKDSNVTPDDDVSGMRSPSAFFKHPTHLVTPSEILMGVSSAEASITTEDRRDRDANIQDVNNDPRDTEVEVKEISEARSTQNGEINDHDETENCTSENREKVFCSQVSNLSTEMARDCYPSTEGTFIPGESKAYGQPIKAGDESGVDSRGGPAKLLKGKKQKAKNSQGPGLSSTSSNVANLADSFNEQSQSLSHPMTDLLPQLLAMQETMNQVMASQKEMQRQLSNAATGPIGKESKRLEVALGRMIEKSSKSNADALWARIQEETVKNEKALRDHAQQIVNATTNFMSKELNAMFEKTIKKELAAIGPALARSVVPVIEKTVSSAITESFQRGIGDKAVNQLDKSVNIKLEATVARQIQAQFQTSGKQALQEGLRSSVESSVIPSFEKACKAMFDQIDSAFQKGIAEHTNAAQQRFDSGHSQLAHTLKESITSASSVAQALSRELAETQRNLLALAAAGANSGGSNSLVTQLSGGPLGALLEKVEAPMDPTTELSRLISERKYEESFTSALQRSDVSIVSWLCSQVDLRGLLAMNPLPLSQGVLLSLLQQLACDISKDTSRKLAWMTDVVAAINPSDQMIAVHARPIFEQVYQILHHHRNAPGSDVSAIRLIMHVINSMLMGCK
The following text describes a protein:
Function:
Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MALRKLQAEIDRTLKSVATGVEVFEATFDKLNYATNTTQKDKLENDLKTQIKKLQRMRDQIKAWLGNGDIKDKTALLENRRLIETQMERFKALEKETKMKAFSKEGLIAQSKLDPAEKAKRDMIDWIGSTTDELSRQIEQTEAEVEALQVGKKKKQAGERLDELEELNERREWHIGRLEVVQRMLENGQLTVGDVEDIQEDVKYFVEANMEEDFDFDNGIYDELNLQDEEDFHDYLHEHPSATDELEPEPEPVVPTQAPKTPAKEKEDKKATPHRLSKSESREKEEEIPPSPVVVKKTPSRKTTLDKDKKDKKDKEKEDKERKERERDEKEREERSSSSQPTPSKPAPLPPIKYAAAAAAAVGGTVSASAPSQTTPSATSEGSRDDIVASPDEIAAAPTSTSFPPPPPGLSRSPSQAATPQTSSPGTPGLQSHAPSTSTGAADMATPSQAPGSAVPPPGYPAPPSSSSAESSRAAVQAQVAAEQAQAQAQAQAQAQAQALVQAQAQAQAQSQLSAAQIQAQLQAAQEVQGQAGVMGNLMQSFEVAKEISKRRSDDTNELHAALEDSFANAPQQMDAEPPRYYHPQNPIKTPSYYPQSRLPILEDKSIYSRLELDQLFYIFYYMTGTYEQWLAARELKKQSWRFHKQYLTWFQRAHNPQAITSDYEQGGYYYFDWENSWCQRRKSDFRFEYRWLSDH
The following text describes a protein:
Function:
Catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP).
Sequence:
MREKDYVVIIGSANIDVAGYSHESLNYADSNPGKIKFTPGGVGRNIAQNLALLGNKAWLLSAVGSDFYGQSLLTQTNQSGVYVDKCLIVPGENTSSYLSLLDNTGEMLVAINDMNISNAITAEYLAQHGEFIQRAKVIVADCNISEEALAWILDNAANVPVFVDPVSAWKCVKVRDRLNQIHTLKPNRLEAETLSGIALSGREDVAKVAAWFHQHGLNRLVLSMGGDGVYYSDISGESGWSAPIKTNVINVTGAGDAMMAGLASCWVDGMPFAESVRFAQGCSSMALSCEYTNNPDLSIANVISLVENAECLN
The following text describes a protein:
Function:
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.
Sequence:
MASGFIEITNKQGLSATLLPFGATLAKLTFPDKEGKNQDLVLGFNTIDEFESDTQSLGKTVGRVANRIKNSQLKFDGKEYKMTPNNGPHYLHGGPNGLGYEDGLPGDAKIDVTYTVNDRNQLIIEHHATCEIPGLLALTNHAYWNLDGSEDVKEHFLEMDSEEYVEVDDTFCPTGAIRCVKGTRFDFRNRKQLKAFGESENEILDLDNDLVIARKDPPITPTSNLRFWSQKSGIELSITTSYPVIHLYASKFLDCSGKNGEHYGANKALAIEPQFHSAAPNFENFPDVSLRPGQDYCQEIVYTFSHVN
The following text describes a protein:
Function:
Forms a concentration gradient along the pollen tube growth path, with a lower level in the stigma papilla cell wall and a higher level in the transmitting tract extracellular matix of the style.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MAKGRGSASWSARAIVTLMAVSVLLLQADYVQAATYTVGDSGIWTFNAVGWPKGKHFRAGDVLVFNYNPRMHNVVKVDSGSYNNCKTPTGAKPYTSGKDRITLSKGQNFFICNFPNHCESDMKIAVTAV
The following text describes a protein:
Function:
GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MRRSKTRRIFHVSITLLLVSTIFCQNGTKPHNNSTSDQMSSSWSNRSQTMYSNASSLLSDLLLDYDIRLRPGFGGDALLLTMDIIIASFDSISEVDMDYTLTMYLHQYWTDERLRWSNEIPIDEMTLSGEFSQNIWVPDTFLANDKHSYLHEVTERNKMLRINVDGKVAYGMRLTSTLSCSMNLRNFPLDSQNCTVEIESYGYTTSEVLMKWNYPLAVHGVEQADVPQFTITGFHTEDSIVSTATGSYQRLSLVFQLRRSVGYFIFQTYLPCVLIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRQSLPRISYVKSIDIYLVMCFVFVFAALLEYAAVNYSYWGRERGKGGGGNEWPVNGANKEDRESAVNVQKWVPSGLMDGVPQPQDRRVEALEEAMSTSNTAAQNNNFESTSKPKKRSSSPIPPLCRAGNTISEESESPDYPRYSTTSLKGARPHASLNHKTHHLKGRSSARAKRRMTLARMNVSMKQSISGIGRRARKVIPTIRVRDVNLIDKYSRVVFPVCFIVFNLFYWSYYMMVPS
The following text describes a protein:
Function:
Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1). Important for stability of PR-DUB components and stimulating its ubiquitinase activity. As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3. MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways. Heterochromatin recruitment is not mediated by DNA methylation. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability; may promote cancer cell growth.
Miscellaneous:
MISCELLANEOUS: Named 'methyl-CpG-binding domain protein' for homology to other methyl-CpG-binding domain proteins and the presence of an MBD domain, MBD5 and MBD6 may have evolutionarily lost the ability to bind methylated DNA and are recruited to heterochromatin by alternative signals.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with heterochromatin containing chromocentres in a subset of cells in a DNA methylation-independent manner. Localizes to sites of DNA damage independent of the PR-DUB complex.
Domain:
Possesses a methyl-binding domain (MBD) that is necessary for chromocentric localization. The MBD may lack methyl-binding activity.
Sequence:
MNGDNASSAADRAGGPAATPVPIPIGWQRCVREGAVYYISPSGTELSSLEQTRSYLLSDGTCKCGLECPLNVPKVFNFDPLAPVTPGGAGVGPASEEDMTKLCNHRRKAVAMATLYRSMETTCSHSSPGEGASPQMFHTVSPGPPSVRPPCRAPPTTPLNGGPGSIPQDPPSVPQAFPPLTGPAGLFPPPRLPDPVPSAGSSSPCFLPRGNAPSPAPPPPPAISLNAPSYNWGASLRSNLVPSDLGSPPAPHASSSPPSDSPLFHCSDALTSPPLPPSNNPPGPPGPPGPATQPPVSSATMHLPLVLGSLGGAPAVEGPGAPPFLASSLLSAAAKAQLPPPSTLQGRRPRAQAPSAAHASPRPSQRRPRRPPTVLRLLEGGGPQTPRRTRPRAPAPVPQPFPLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPALSSGSPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSPSDGLGMGAGPACPLPPLAGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPSPFLSHSLFGVLAGGGQPPPEPLLPPPGGPGPPSAPGEPEGPSLLVASLLSPPPSDLLPPPSAPPSNLLASFLPLLALGPTAGDGEGSAEGAGGPNGEPFSGLGDLPPLLFPPLSAPPTLIALNSALLAASLDPPSGTPPQPCVLSAPQPGPPTSSVTTATTDPGASSLGKAPSNSGRPQLLSPLLSASLLGDLSSLASSPGALPSLLQPPGPLLSSQLGLQLLPGGGAPPALSEASSPLACLLQSLQIPPEQPDAPCLPPESPASALEPEPARPPLSALAPPHASPDPPVPELLTGRGSGKRGRRGGGGLRGINGETRPGRGRKPGSRREPGRLALKWGTRGGFNGQMERSPRRTHHWQHNGELAEGGAEPKDPPLPGTHSEDLKVPPGIVRKSRRGRRRKYNPARNSSSSRQDVTLEPSPTTRAAVPLPPRARPGRPAKNKRRKLAP
The following text describes a protein:
Function:
Catalyzes the sequential condensations of isopentenyl pyrophosphate (IPP) with geranyl diphosphate (GPP) to yield (2E,6E)-farnesyl diphosphate (E,E-FPP), with E,E-FPP to yield geranylgeranyl diphosphate (GGPP) and with GGPP to yield nonaprenyl diphosphate. May also have weak activity with dimethylallyl diphosphate (DMAPP).
Domain:
Contains the canonical two aspartate-rich DDxxD motifs, designated as FARM (the first aspartate-rich motif) and SARM (the second aspartate-rich motif). The primary role of the FARM and SARM is the chelation of the divalent magnesium ion cofactors that assist substrate binding and catalysis, but it may also play a role in determining product chain length.
Sequence:
MRTPATVVAGVDLGDAVFAAAVRAGVARVEQLMDTELRQADEVMSDSLLHLFNAGGKRFRPLFTVLSAQIGPQPDAAAVTVAGAVIEMIHLATLYHDDVMDEAQVRRGAPSANAQWGNNVAILAGDYLLATASRLVARLGPEAVRIIADTFAQLVTGQMRETRGTSENVDSIEQYLKVVQEKTGSLIGAAGRLGGMFSGATDEQVERLSRLGGVVGTAFQIADDIIDIDSESDESGKLPGTDVREGVHTLPMLYALRESGPDCARLRALLNGPVDDDAEVREALTLLRASPGMARAKDVLAQYAAQARHELALLPDVPGRRALAALVDYTVSRHG
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSTNNTTTNNEDLISSLYPPPPPYYKFFTKDNLQKLSTWQENNQTTTVSSEVKLEEENTDPDSNNSEENSIPPGELRFLIPPKQPEGPQYRGYGNIWLFEDKLPNLKDSQWEQLYNTSTSTFTSTSTSTANTNIITNTDTDINGNQEVDAGDSTGDENLTSETKIKELHKLMDSLLLNFLELIGILSIDPIKYDKKIHDINLILININHLLNTYRPHQSRESLIMLLKNQIDYKFLEIDQINKKCLDIKSKIKNLINERITVVSDGTTTNTTTTTKTTGLGDGDSIDEKEQLKQDIINRLLSSI
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of a cytosine in 25S rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDFYNHAANILSDLSKKKGSIKQLAFNSKKHDPKRTYALVCETLKYKPVLDEIIARSELLVLEKKLKENLARVLVHDLLMSKRGLSISNGPIKECILRHKTRLNAEFVKLKVKKGVKSHEELALKNPVSLPRWLRINTIKSTKDEVLQGLGLDKVSSIEELGPDKFYIDDCVENLIAIDPSFPIVENSLYKEGKVIIQDKASCFPAAVLAGLTGHVGDIIDGCAAPGNKTTHLAACFPKSHIFAFERDAKRVQTLRKMVGISGANNVTIEHQDFTLTDPKSDLYRNVTHILLDPSCSGSGIVSRQDYLLGNEQDVTEDTERLENLCSFQSTILKHALQFPNCRHVTYSTCSVHRLENEQVVCEVLSQEPDWKCNSLTKTLPNWKTRGIPEYCAQPSMAEGMIRCKPGAGGTIGFFVANLYHPQREQETFKMYKNDDDTKKRKRKKKKKEVKKKARIQGEE
The following text describes a protein:
Function:
Transcription factor; binds and activates the promoter for the HNF1-alpha gene. Seems to have a lower DNA binding activity than HNF4-alpha and is a weaker transactivator than the alpha isoform.
Subcellular Localization:
Nucleus.
Sequence:
MDMPDYTETLDSSYTMLEFDSIRVLPSNTEIITVETASPGLLNNGINSFCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHVYACRFSRQCIVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISMRRSSYEDNGSLSINVLTQAEAMVHQYSPVSPVHSSDISMKKVASISDVCESMKQQLLLLVEWAKYIPAFCELPLDDQVALLRAHAGAHLLLGVAKRSLPYKDFLLLGNDFIMPMHCPELEIARVPCRILDELVKPLREIQIDDNEYVCLKAIIFFDPDCKGLSDQTKVKNMRFQVQVNLEDYINDRQFDSRGRFSDILLLLPPLQSITWQMIEQVQFAKLFGVARIDSLLQELLLGGTTMDGGQYINSGHSSLNLDLLPGPTVHSHNLHSVIHTVSSLSPETSPPTNSTSEDYKMNTATVSSIPLMQRTVIAKKEIL
The following text describes a protein:
Function:
May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity. Component of the elastin-associated microfibrils (By similarity).
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MLFLGQKALLLVLAISIPSDWLPLGVSGQRGDDVPETFTDDPNLVNDPSTDDTALADITPSTDDLAGDKNATAECRDEKFACTRLYSVHRPVRQCVHQSCFTSLRRMYIINNEICSRLVCKEHEAMKDELCRQMAGLPPRRLRRSNYFRLPPCENMNLQRPDGL
The following text describes a protein:
Function:
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Sequence:
MLHDRRGPSHVTKTIFFSVGEPSGDQHAARLIRQLANPGGMAMRNDERIICRGFGGPSMLAAGCRVDLDLTRHAVVGIVEVLPKLREFFRFADQAEDIFRSGSVDSVVLVDFPGFNWHIAKRAKKYGIPVHYYCPPQLWAWGAWRVRKMKRSVDHVVAVLPVEQSFFNRHQIPVSLVGHPFFDAVAEQKLDTAVMRRFQSQQNSGDRVVAVLPGSRDHEVRANFPIQLETIRRLDRELSQSGENVRFAVAAYRDKQCLWCREQLSEEDKDLPIDFYVDCTSEIIEAAHCAMMVSGSVSLELLARETPAAVIYRVGRVLHAVGKRVLKIDSVTLPNLMAGRKLFPEFISVGDPAPAVDFLTETMRAMLQDSFYYAKIRRDLQKLRDEHARPGASQRAAELLRSKLFGDLETLPEKNSFGMQTQMRDAA
The following text describes a protein:
Function:
Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium (By similarity). KCNU1 channel auxiliary protein. Modulates KCNU1 gating properties, shifting KCNU1 gating to more negative potentials at a given pH.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Note=Expression at the cell surface may require the presence of KCNU1.
Domain:
The transmembrane domain is necessary for interaction with KCNMA1.
Sequence:
MSLASGPSSKLLLFSLGMGLVSGSKCPNKCVCQDQEVACIDLHLTEYPADIPLNTRRLYLNNNKITSLPALQLGFLSDLVYLDCQNNRIREVMDYTFIGIFRLIYLDLSSNNLTSISPFSFSVLTNLVRLNISHNPHLLYLDKYVFANTTSLRYLDLRNTGLHIIDHNGFHHLVVLQTLYLSGNPWICNCSFLDFTIHLLVSHMDHPDAQNATCTEPAELKGWPITKVGNPLQYMCITHLDQQDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNALRTSSGDDTEDETGSRFANQIFRSNTHLGPIRRFPELI
The following text describes a protein:
Function:
Endolysin with L-alanyl-D-glutamate peptidase activity that degrades host peptidoglycans and participates with the holin in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer by hydrolyzing the link between L-alanine and D-glutamate residues.
Sequence:
MSFKFGKNSEKQLATVKPELQKVARRALELSPYDFTIVQGIRTVAQSAQNIANGTSFLKDPSKSKHITGDAIDFAPYINGKIDWNDLEAFWAVKKAFEQAGKELGIKLRFGADWNASGDYHDEIKRGTYDGGHVELV
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDFWKLFIVALLPVLKVLLITAVGTILAINRLNILGETARKNLNTMVFYVFSPTLVCSSLAETITLENVLILWFMPVNILLTFVIGSVLGLLVVKLTRVPHHLQGLVLGCCAAGNLGNLPIILVPAVCKQSGSPFGDVNVCYKNALAYASLSMALGSVYIWSYAYNLVRLYSPKISNEVKVDDNSVVENPVSTTKSDPENPSTFSTELPFVSADDRSQTEDHVKHFEIQCTGHNGQVEEVSKNRTIMNHLIILVQKVNLKVLFTPSTIGAIIGLIIGVVPQFRKLLVGDNATLRVVEDSVIMVGYACIPVMTLLVGANLIKGLNGLGKQLPLIIGVTMVRCIVLPAIGIGVVKGVVRLGLIHPDPLYEFLLLLQFALPPAVAMSTITQLFGAGEGECSVIMLATYSCAAVSVTLWSTFYMWLVL
The following text describes a protein:
Function:
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
Subcellular Localization:
Secreted. Bacterial flagellum.
Sequence:
MAQVINTNVMSLNAQRNLNTNSSSMALSIQQLSSGKRITSASVDAAGLAISERFTTQIRGLDVASRNANDGISLAQTAEGAMVEIGNNLQRIRELSVQSANATNSATDREALNSEVKQLTSEIDRVANQTSFNGTKLLNGDFSGALFQVGADAGQTIGINSIVDANVDSLGKANFAASVSGAGVTGAATASGSLSGITLAFKDASGAAKSVAVADIKIASGDTAADINKKVASAINDKLDQTGMYASIDTSGNVKLESLKAGQDFTSLSGGTSGAAGITAGAGIQTASAASGSTASTLSSLDISTFSGAQKALEIVDKALTSVNSSRADMGAVQNRFTSTIANLAATSENLTASRSRIADTDYAKTTAELTRTQILQQAGTAMLAQAKSVPQNVLSLLQ
The following text describes a protein:
Function:
Chaperone required for proper molybdenum cofactor insertion and final assembly of the membrane-bound respiratory nitrate reductase 1.
Subcellular Localization:
Cytoplasm.
Sequence:
MIELVIVSRLLEYPDAALWQHQQEMFEAIAASKNLPKEDAHALGIFLRDLTTMDPLDAQAQYSELFDRGRATSLLLFEHVHGESRDRGQAMVDLLAQYEQHGLQLNSRELPDHLPLYLEYLAQLPQSEAVEGLKDIAPILALLSARLQQRESRYAVLFDLLLKLANTAIDSDKVAEKIADEARDDTPQALDAVWEEEQVKFFADKGCGDSAITAHQRRFAGAVAPQYLNITTGGQH
The following text describes a protein:
Function:
Probable carboxypeptidase.
Subcellular Localization:
Secreted.
Sequence:
MRISHHVVHSVLVLFLVSCLLGSSLAAKLCSDDDKDGDNGCFRSRVLAAQRADLVKELPGQPPVKFRQYAGYVTVNETHGRALFYWFFEATHNPNKKPLLLWLNGGPGCSSVGFGASEELGPFFPQNSTQPNLKLNPYSWNKAANLLFLESPVGVGFSYSNTSRDISQLGDTVTASDSYNFLVNWFKRFPQYKSRDFYIAGESYAGHYVPQLSELIYNQNKIAPKKDFINLKGLMIGNALLDDETDQKGMIDYAYDHAVISDGLYQRVNEHCDFRLAHVSKECDGALDEYFDVYKILDMYSLYSPRCVPTTENSSVSHSVAGSRHLPAARGIFRPRLVSNNEGWRKMAAGYDPCASDYTEKYMNRRDVQEALHANVTNLSYPWTHCSDHISFWADAPASMLPTLRTLVSAGLRVWVFSGDTDGRIPVTATRYSLKKLGLKTVQDWTPWYTNKQQVGGWTVEYDGLMFVTVRGAGHQVPTFKPREALQLVHHFLANKKLPTFPF