lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Sequence:
MSYPNQMNGSMYGYGANNGVQPGFDSYGMPINQGGMNYQQQTYPYQQPYQPDGYAGNTMLPFQQSQPATQFNNGFGYASQPTGSVADYGQQQQQMYGYNGMMPQTMNNTGFMQPQQTGAIPGFAPQPTGFVQPQPTGFMSQQPASFMQPQRTGGAGFIQPQRTGAMPAYQPQMNNFMQPQKTGGFAPQATGFMQTQPFGAAPSFAPQPTGFVQPQQTGVVMPPQPTGYLQAQPTGPFASFVQPQQTASFMPAAQPLKPQKTGQIHNSKAMDTRLSFVSAADQAKFEQLFKSAVGREEAMSSEIGKAILVRSKLPTVQLSKIWRLSDTTRSGRLLFPQFVLAMYLCNLGLTGKPIPDKVPDGILNEVNAMVDAISFSLDENYAKPTQPIPQAAAQQMAAQMFGGFQQAAGIPSQITGFQPQAMMPQRTGMQPQMTGFQQPMIPQRTGMQPQMTGFQQPMMPQRTGLQPQMTGFQQPMVPQRTGMQPQMTGFQQPMMPQRTGLQPQMTGFQQPMVPQRTGMQPMMPGLQQPMAPQRTGMQPMMPQRTGMQPQMTGFQQPMAPQRTGMQPMMPQRTGMQPQMPGMQQPMAPQRTGMQPMMPQRTGMQQPMAPQRTGMQPMMPQRTGMQPQMPGMQQPMAPQRTGMQPMMPQRTGMQPQMPGMQQPMAPQRTGMQPMAPQRTGMQPMMPQRTGMQPQMPGMQQPMAPQRTGMQPMMPQRTGMQPQMPGMQQPMAPQRTGMQPMAPQRTGMQPQMTGGPMLPQRTGGMAPQPTGMPGQWGFINTPLSNLPGIEALGQQMMPNAPSGGLNNTFQQKKDIPWAISKEEKRIYDQIFDAWDKERKGTLGGNAVLEIFGQSKLTRTELEHIWNLCDHGDKGSLDRDEFAVALHLIYRKLNGNEVPAVLPPELIPPSTRNFTESLNQVKNLIKNDTSNRKPFGAENQSKLKKNSFYDNPSETTEKDATLYRHNDSDASAYVSSARRRDFKEEKIESAPPIINDIDSEIASLKKRIHEKSLVVNALEDKKLAATPANDVQNDSLIYRIKSVQDEINRLSTSNKSPEVASMNVRLEELSTRVSKMLSDINEVDHTIASLSLKLFQAEDTKNSYDQTSPEATQERNRTISSKLAEMEKQKNESKAALEQMKNYVTNIENNIRAKLLPSAANDDAWLSQNVVDESVTRVVKELPVPAPAAPQTLNPPSVSTVQQSKPIESNTHTPEVKATSESPSASSNLEDRAARIKAEAQRRMNERLAALGIKPRQKGTPSPAPVNSATSTPVAAPTAQQIQPGKQASAVSSNVPAVSASISTPPAVVPTVQHPQPTKQIPTAAVKDPSTTSTSFNTAPIPQQAPLENQFSKMSLEPPVRPAVPTSPKPQIPDSSNVHAPPPPVQPMNAMPSHNAVNARPSAPERRDSFGSVSSGSNVSSIEDETSTMPLKASQPTNPGAPSNHAPQVVPPAPMHAVAPVQPKAPGMVTNAPAPSSAPAPPAPVSQLPPAVPNVPVPSMIPSVAQQPPSSVAPATAPSSTLPPSQSSFAHVPSPAPPAPQHPSAAALSSAPADNSMPHRSSPYAPQEPVQKPQAINNIAPATNLGTSQSFSPRMGPVNNSGSPLAMNAAGQPSLAVPAVPSAPSNHFNPFAKMQPPAPSPLQPSGHDSDNWSQHGDEEEEDSEDDIRSSKDAAALAAKLFGGMAPAHPVSTPPVRPQSAAPPQMSAPTPPPPPMSVPPPPSAPPMPAGPPSAPPPPLPASSAPSVPNPGDRSALLQQIHTGTRLKKTVTTDKSKPIAGRVLDASDGNSSAWYGNLS
The following text describes a protein:
Function:
Binds to both sense and antisense RNA. Can also bind sheared DNA and dodecamer DNA with a low affinity. Interacts with mesophyll plasmodesmata to mediate its own cell-to-cell transport and potentiate RNA trafficking (By similarity). May play a role in plant defense signaling (By similarity).
Sequence:
MAVGILEVSLISGKGLKRSDFLGKIDPYVEIQYKGQTRKSSVAKEDGGRNPTWNDKLKWRAEFPGSGADYKLIVKVMDHDTFSSDDFIGEATVHVKELLEMGVEKGTAELRPTKYNIVDSDLSFVGELLIGVSYSLLQDRGMDGEQFGGWKHSQVD
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MSAQDVNKAVQIALDASADPAIKEQATSFLNSLKDTAGGCTLCLEVFSSGQTSDASTRLVVLQLLVEAVRSGTVLSVFPDFLKVLQEKLWAYILARQFVGEPPYINNTLQHLLSLLLVRTYPQQWPDFFSGFHTLIDGVGTGAGDAVVEFYAKTLLAIGEEIGDVLTPHTSEEMQRIADVKDAIRSNDVSNIISHVYNTMLRSSEANKNNLVELCLQVIANWVSWIDINFVVNEPFLNALYSFLQSNDLRNTTCRTLVEIVYKKMKPPEKLNILNLLNLNYFISQLRQQSEADPAFDEELARLVNAQGVELVNICLNASSAGLGADAVESASALLSQTLGHLIYYLSNEYDETSEAVFPFLTDVLTMLRKEASGAKTMDSTRQELLVSILNAVVKKMKYDDSEEWDDDAESEEEAEFLELRKKLKTFQDAIGAIDSKLYNEYMYDAISTSVTNAASMSAGRSWQLMEFALFELYIFGEGVKGSAAFITADKQPTNLSRLLALVIGANVCSACPHPLVQMLYMDILVRYAGFFEYEPKLVYPAVEFFLSDMGIHSTNTRVCVRAWYLYYKFLKSVPRHIPEFAAVALKMQSDLLTVSDNNINPADFPQSSIETLVRQCSFNSRLYLFEAAGILVSGSSQALSDADKSAFCDSLISTLQNQLTQGLSSGLDSFDNLVRVYCSILAIGNLAKGFPPFSDRSGPWVSCFNTAAEVLFQALQACSTVVDIRTATRFSFARIVSVLGPSMLPKIPQLVDLLLSSITTDELTDLLSFLGQLSHLYKAELVSVINSLLGTLLTRIFASLAQQPQGTDDAIKQNDLRKSYVAFLVMLVNRGFSQVFFTEQNQQYFDGVLQSVLHFANSIGDPSIQKSSIALLSKMVVMWGGDGGIGGFETFMYSSLLPLCFEMPFNQSFNVSDGMSHVVLGELALLQKSILQVKGPSFVEYLTSVYFPSVNFPQALVGEYAESLTTLADRAFKQYFQKFIQSMKN
The following text describes a protein:
Function:
May be a proton symporter involved in the uptake of osmolytes such as proline and glycine betaine.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MEREAATSPTENGPETDAAAVRRHPALFRAIKRRQNPRLRRSDITVTDEAAVKRAVKAASLGNAMEWFDFGIYAYLAGTIGRVFFPSGSDTAQLLSSFATFAVAFLVRPIGGMVFGPMGDKIGRKKVLALTMILMAIGTAAIGFIPSYDSIGFWSPLLLILFRLLQGFSTGGEYGGASTFIAEYAPDKRRGFFGSFLELGTLAGYTAAASLVTALTAVLGSDGMDSWGWRVPFLAALPLGMIGIYLRLRLDDTPAYLKLEDSNVHVSEAATAVETTARGDLAKIFRTHWRALVLCIALVGAYNITDYMLLSYMPTYLSDELDYSESHGLMILVATMVLLMLIINQVGRLSDRFGRKPVLMTGMIGFFVLSAPAFVLVQEGSLLAVSGGMLMLGLSLVCLLGTMSAALPAMFPTNVRYGSLSVGYNLSASLFGGTTPLVITALISVTGSDMMPAYYAMAAALIGVVAVACMKETAQQPLAGSPPSVQTEEEAAEMVEAQAPTPKF
The following text describes a protein:
Function:
Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.
Subcellular Localization:
Mitochondrion membrane. Nucleus. Secreted.
Sequence:
MASRTLRVLCHFSRSGSQSVTPSANYFSCRLASRGIGRAWKGHNPEHGDTKSNGPTSGDDVADDGDVDLEDVEEKFQAFFDKERKAQKTVKYHIMRRKMTPAGAPERRLTWEAIDQIRYLKNNQPDEWSVERLAEGFSATPEEIRRVLRSKFMPSPDKKTKQDAKVMARLGLQSLPPGAGTQQDNLKKLPGNHKSTMLPSGGKNSLVPSSGQTPLVKYDASRSLVQIPASVNAPSPQLKTQVAEDAAVIRTAESTTEKSPTEEDEWSWDGQVLTEEQLSDLLEEVKNPPPVQKIGNDYFDAEGNFLYRI
The following text describes a protein:
Function:
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
Subcellular Localization:
Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic.
Sequence:
MAQDSVDLSCDYQFWMQKLSVWDQASTLETQQDTCLHVAQFQEFLRKMYEALKEMDSNTVIERFPTIGQLLAKACWNPFILAYDESQKILIWCLCCLINKEPQNSGQSKLNSWIQGVLSHILSALRFDKEVALFTQGLGYAPIDYYPGLLKNMVLSLASELRENHLNGFNTQRRMAPERVASLSRVCVPLITLTDVDPLVEALLICHGREPQEILQPEFFEAVNEAILLKKISLPMSAVVCLWLRHLPSLEKAMLHLFEKLISSERNCLRRIECFIKDSSLPQAACHPAIFRVVDEMFRCALLETDGALEIIATIQVFTQCFVEALEKASKQLRFALKTYFPYTSPSLAMVLLQDPQDIPRGHWLQTLKHISELLREAVEDQTHGSCGGPFESWFLFIHFGGWAEMVAEQLLMSAAEPPTALLWLLAFYYGPRDGRQQRAQTMVQVKAVLGHLLAMSRSSSLSAQDLQTVAGQGTDTDLRAPAQQLIRHLLLNFLLWAPGGHTIAWDVITLMAHTAEITHEIIGFLDQTLYRWNRLGIESPRSEKLARELLKELRTQV
The following text describes a protein:
Function:
Involved in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes; Precursor of the catalytic component of the C3 and C5 convertase complexes of the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The alternative complement pathway acts as an amplification loop that enhances other complement pathways (classical, lectin and GZMK) by promoting formation of additional C3 and C5 convertases. CFB is cleaved and activated by CFD to generate Ba and Bb chains; Bb chain constituting the catalytic component of the C3 and C5 convertases; Serine protease component of the complement C3 and C5 convertase complexes of the alternative complement pathway. Following cleavage and activation by factor D (CFD), forms the C3 convertase together with complement C3b. As part of the C3 convertase, cleaves and activates C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways. When an additional complement C3b molecule binds to the C3 convertase, forms the C5 convertase, which cleaves and activates C5 into C5a anaphylatoxin and C5b component of the membrane attack complex.
Subcellular Localization:
Cell surface.
Sequence:
MAPKLLLFLLCALLTFCPVVDAQEPATPSCPINVAIRGGTVTFSDEGRLGSTLTYSCPPGTYPYPLQSRVCQSDGKWTPMRSPHGPRVNTAQCREIRCPPQMSFEHGSSSPRRSSHPIGDILSFECYDGYQLHGSSQRHCLPNGRWNGTSPVYHGNATGTNTYAALDAIYRMMINDRANVLEKWDKVRHAIILLTDGKSNLGRPPKDAVRSIEGLVNVGENRKDYLDPKDLDDICGLANYSINAEWYQKNPWHVLLQENHQTEPSCRGALISKTWILTSAHCFNKLNDISTWRVILGGESSLSIKRRIDHDLYNVRAKLSQGIQEFYDYDISLLELENPVPFGGRIRPICLPCTEGANKALKKKSGTTTCKDHELELLSFEKVPAQFISLDNKRMNVRIKTKTSRPSCISGAVQEGMIYSQVSDASEVVTDRFLCSGDDNGVEAATCKDIHCNRPVEFENGMYEPRQPYYNVSQELTFECYGGYTMRGSQKRTCLPNGKWSGETTICDDGAGHCRNPGIPIGARKAGTQYRIEYKVQYTCERGLSLVGSKERVCQESGVWSGAEPECRSPFSYDTPEEVSSKFISSLTETAESSDSDKNVSTTGKRKIKIEKDGSLNIYIVLDASRSIKKDQFKHAQNMSIKLIEKISSYDISPRYAVITFATEVKELVRTTDDQSTDASWVIEKLEGMKYTEHKQKPGTNIQKGLSSVYSMMITQQAAERRRGLNPPPVSEKTRHVIVLLSDGDYNMGGDPIRVIRQIREFLNIGRNRTHPREDFLDVYVFAVGGTVVMENVNKIASQKSGERHAFKIKDYSDLQLAFEEMIDESETLSMCGLAKEHDTPDHQQKNPWYTKITIRRTGGVYEHCKGALVSKYFILTAAHCFTIDDIADQITVTIDKKPYNVKALYSHPNYQIGRLANKGIPEFYDYDVALVELASPVMPSPPYSLPLFCGPFCFTALTQYSWLSSEEELLPTANVNSLFVTECNDNKELRRRTVRIKNGDQKFACEEDAKKADQYKNVTNVADVVTDRFLCTGGFDPEWDPNTCKGEHFQYRYRYRWISRDFHVPAYLYLYIYIILYMNFPLTCLQVFANPL
The following text describes a protein:
Function:
Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility. NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells. Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Endomembrane system. Note=Localizes to cytoplasmic membrane in tumor cells.
Sequence:
MVFYFTSSSVNSSAYTIYMGKDKYENEDLIKHGWPEDIWFHVDKLSSAHVYLRLHKGENIEDIPKEVLMDCAHLVKANSIQGCKMNNVNVVYTPWSNLKKTADMDVGQIGFHRQKDVKIVTVEKKVNEILNRLEKTKVERFPDLAAEKECRDREERNEKKAQIQEMKRREKEEMKKKREMDELRSYSSLMKVENMSSNQDGNDSDEFM
The following text describes a protein:
Function:
SNARE required for protein transport between the ER and the Golgi complex.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MNAIHNHLVKQNASLKKDLSEFSANPAGAPMSLQGQISATMTSFSRTLDDYSEIINKEHNKEKKEKAEARLARFREELADARSEFKNLRSAREEKTLEENKTALFGDNPYGESRNRNVNRDVPIQPTYTDLTREEGMQREQSSLNQVGQQLDSFIEQGMAALGDLQEQSDILRSTGKKMRSVAETLGLSRETIKMVEKRARQDKRFFYGGIVFMLVCFYYILKWFS
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MASRLKFLMLERSGTMAFLIISCSSAMCSTLSLKITYHAEIAGFSLSVFFNSVLLILISDMPRKTFGSYKYLMICFSICGIYFSCCDFWCKPYVHMSKNSFAIFNVLEETKLTQNTGVIALELYCSCYAIIISLITIHFYYRYLSVMFPVKLVRFSVRNLPFWILLVILNASVWFLLNSLVNGPSEIQDAILIPEIRQRACLERHEYTYVGNVFLYQDFETNTRKINIIAFLSFGIIGSVMTFSLATLGYFGAKTYFHLKKISSLAVSYQEIQRQLFQTLVIQTIIPITFLYTPVTLMYLFPVFGIQFVEIGYIAPPLVALYPCLEPLVAMYCIKSFRFRILGWLTCHKYKRNVVHVSFVQTN
The following text describes a protein:
Function:
Plays a role in controlling food intake and regulating body size.
Miscellaneous:
MISCELLANEOUS: Flies overexpressing sNPF are heavier and bigger than wild-type. But loss-of-function flies are not smaller than wild-type.
Subcellular Localization:
Secreted.
Sequence:
MFHLKRELSQGCALALICLVSLQMQQPAQAEVSSAQGTPLSNLYDNLLQREYAGPVVFPNHQVERKAQRSPSLRLRFGRSDPDMLNSIVEKRWFGDVNQKPIRSPSLRLRFGRRDPSLPQMRRTAYDDLLERELTLNSQQQQQQLGTEPDSDLGADYDGLYERVVRKPQRLRWGRSVPQFEANNADNEQIERSQWYNSLLNSDKMRRMLVALQQQYEIPENVASYANDEDTDTDLNNDTSEFQREVRKPMRLRWGRSTGKAPSEQKHTPEETSSIPPKTQN
The following text describes a protein:
Function:
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.
Sequence:
MSRKHFFPNPEGVVVHMLNSLITRNQHMGLDTENRVVYNLAHPPNQVTIISGGGSGHEPAWSGFVGDGMLSAAVCGDIFASPSTKQIMAGIRNVPSNEGVILCITNYTGDMLHFGLAREKGQALGYKVDVVCMAEDAALGREKSEKVGRRGLAGNLLVIKLAGAASQKGWAFERCRKIGELGNSQLVTIGTSLDHCHVPGREAFESVKDDACVLGMGIHNEPGLRTISPMPSPQDIIKEMLRYLLDPKDKDRAFVPFSPTDNVVMLCNNFGGLSNLEFDAMVNIALEKLKSDWSIVPKRIYAGVLETSLNGQGFSITLGNMTGMAKAMDLSDEEVFELLDAPTNAPAWPKNGYRPVNISKETETLRNAANAAHANSSTTHKGPATPASLIPALRTACKAALAAEPTITQYDLQMGDGDCGEAVAGVCKSILTNIDAVEANPPALLALLESIGENVEDSAALDISTIARAAALGLENLKNYTSAREGDRTVMDVLIPFINTLNESRDLEKSVSVAEQSAQKTAEMKAKFGRATYISEDGSERSRIPDPGAYAVGVWCRGLVEGYKG
The following text describes a protein:
Function:
May regulate DNA damage response and cell proliferation.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MADDVSEFLGQNPETAAWLELVHGECESDKLWRYRKEFILRNLSDVCGEAEVPPPPETNHKALDRLLAYSMVWANHVFTGCRYPLPVMEKVLKMAENIKVTDAPTHTTRDELVAKVKKRGISSSNEGVEEEPCKKQKSSDHGERESSYIEDTISDGNVPSTSLNKREARLSAAQRTDVNTEFYDKSSNRRSLPVSNAKSRLNLPEEAGYKHGATQGRKSHSDIRHQTSMKGPAQSSDNALKPTRRFTTEHTKERQPFFNRLYKTVAWKLVSAGGFNANLNHEELLNTCIESLKATLEVSFVPLTDLADLPQNKTSQENTVCELRCKSVYLGMGCGKTMETAKAVASREAVKLFLKKKVVVRICKRKFNGRDVEDLVLVDEEFRPVNLPPAIKNPQEIV
The following text describes a protein:
Function:
Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
Sequence:
MAILSISSVVVAATLIIITTAFLRLLYVISPDSRRPPIKKKDEPSHIVVVLGSGGHTAEMISLLRDTNVARYKHRTYIVSAGDDFSSTKAHDCEERIQSKLRPSLPCTKSGEFDSTTGIWDLIVVPRAREIHQRLYTAPISSFWCMLGCLKALYTISTTSTIHQQYPDLFTKISRAGPNMEDANDLCGKLGEGEDIKSKWKDFIMAGDL
The following text describes a protein:
Function:
Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MADADWKQRVGIPIDFSTDEDEDSDSTETVCSNTEPGATRQFRGEEFADSTESQELEEALHASSIDEVLNQWADQYGSTPPRTRIKNKNRSSKQRMEGTVKMRTGGGRLARPRTDRRNTVDCALLNQMIMEPANGEEKVRSDKRSTQLLRDSERDIKMSAAATVLPLRASANYGSQLPAGAGGPVLEERAESLPLSVPGGLGGLVAVGSGAAGSPAPPPTLIESCNRFMSVTSRPVGCRISAPPVAYRDVIFNSQPGVIEGVSGARTVDCAIPQNRINFHATFSDLIKLGSVDKERAARSGVLSNEERLWQTHVNDLIWLELQAWHADRSIEQQDRLLCQARHEIGDLLEEIMSFRFQRKPAAVRRAGSETSTGTTADSGIETATTTGGSGGVEGNRFCFGCLSMYCKDCLEVQTAAMKQVEELLLRLESKECLFPSSRAMGSAFPVYQSEAFVNRVKAMCLWYNMTRQHRMTLLILGKLLARLQGPSKKESSIHWPIMEHHAEGSSSSSVQDESGSSADSGAHYSANGGGGSTSGSGSGTSSNCSKRVQFADGGGCCAGDGSASESVNSDETDFSDLSLNRERPYPGDTEYGRYMNNLNFYNEHTLTELSAQSASSMGNALYRKYIENVLKCRGLGKSLTFLHRLHNVVLRKAQLTLEKPGRQQEDDCLFDEEDVPCIEPPLEREQEIELRRYGAWSEEAKQLNLPSYVSAFLFLSLIPLEVIHEFLKMRLETRPKQPNPLSLEQHIKELKEGLTLAMIHRERFQKHINTVLSDREQELNKYMHQMELFDDTVRNIFELYLELCEQWILDTVPEGHQKAVLDEEWRFTKLISPMIPREHGPAARRFCSIVERVLERTGSDMMRQLKELMEKSQQIDSTTDGKKWQFFALCRETQRMFTVSREKALKTMAFAKTLFRDLEHADFHRDHCEDDSESELLNGGDDGDDLELVGVVLRSGNLRRSARGAPDAANPIGHTRSPVCSEVVESLQMLKRNALLLRNKLAAVIEELQLLCSDESLEEFDEIDRLGALTRVREILHQGYKFGFEYHKDVARLYETRLNNCRDGESELMLAKAIIQFAKLWMNFVMERCERGRGLRPRWANQGLEFLIAACDPLCTSHLTDAEFEDLKLKMDACISHVIGNIREPERIRKSPRSRKSSPSPSAAAVAAAAAAGGGTPTVTTGRASIPMVNLPSKSFQNQLSLREDGVMLRTNSPIEAADLYRKQTSCDNVTEVKLRVPSTPNAASLVAGELCVHGTRPLRQLRVRDAGRFGKVYTAVNNSTGELMAMKEIAIQPGETAAIRKVAEELKIFEGISHQHLVKYYGVEVHREELIIFMELCPEGTLESLVELNGGLPEAQTRRYTHQLLSAVAELHRNGVVHRDIKTANIFLHKDGNCLKLGDFGSAVKIQAHTTMAGELKGYVGTQAYMAPEVFTRNNTEGHGRAADIWSVGCVVVEMSSGRRPWHQFDSNFQIMFKVGMGESPEIPENLSEEGKDFVGICLQHDPKDRQKADELLQHIFCKFTFYDPEAIDKKLRGTFRRNLKSTTSASS
The following text describes a protein:
Function:
Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
Subcellular Localization:
Cytoplasm.
Sequence:
MSIQLSEDGELQVQGYLRFAKLKRDQHVREVVSTINDFKADHLRAGDMYNYKELTQMFTELADDTKKLMDKEIQNAYHTNALLVKILLSQAQAQGLELAVDTNSLENEFLLKQISSSEATALSRPASDFVRRNTQLGRLGTVATVATQDPAVVRERDALRAELQEAKERMAKLQEETTKVMRDRTTLNNQLNSLRDELAAKDTALRAALGDKEAAVAGLSNKMAALEAAGRGGVSAEAAAALEKKAGGLGGQLAAVQEELQAARNQLALKDKELRAASEALSGKLQESKQFLAMKQMMQSKSQEAAALRKRLEQYEPQSVPSADTA
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MAQSTEDNTRRPRPSDLPEMFRPPVNRAMRVLDRSFFKKTVPLSAATIFKNSDISRVRRALEQSKDILALPRLNTIQDIKQDDVVKKCLLLKETIRHDDTATWSPTINELVDNGVVGVGPFDLTLDYDYWLHSDIISAVLPEELLEEVPQGFTQVGHVAQLNLREQFIPWRHLIAQVLLDKNPTLRTVIRKTEDVGSQSEFRTFPYELLAGDSDMNVIQHEQDCEFRFDFSRVYWNSRLHTEHQRLVDLFKPGEMVCDVMAGVGPFAIPAGKKKIFVWANDLNPHGYEVMQDAVKRNKVFKFVTPFNQDGRSFIRWSARALQKYDPVTVTIQPRTKRTRDASGQVKETQPPLEVYTRPKVFHHYVMNLPGNALEFLDAFIGVYAGCEELFEPHTKEQLPMVHVYCFSGHSENEVDDHIDICKRMSERLEYPITVEDRVGGAGNTELELSIHNVRLVSPNKQMFCASFRLPRAVAFRKK
The following text describes a protein:
Function:
Male-specific peptide with moderate activity against Gram-positive bacteria.
Subcellular Localization:
Secreted.
Sequence:
MKYFVVLVVLALILAISVGPSDAVFIDILDKVENAIHNAAQVGIGFAKPFEKLINPK
The following text describes a protein:
Function:
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (By similarity). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (By similarity). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by mre-11, to initiate end resection, which is required for single-strand invasion and recombination (By similarity). Within the complex, rad-50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of mre-11 (By similarity). Rad-50 provides an ATP-dependent control of mre-11 by positioning DNA ends into the mre-11 active site: ATP-binding induces a large structural change from an open form with accessible mre-11 nuclease sites into a closed form (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to DNA double-strand breaks (DSBs).
Domain:
The zinc-hook, which separates the large intramolecular coiled coil regions, contains 2 Cys residues that coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another RAD50 molecule, thereby forming a V-shaped homodimer. The two heads of the homodimer, which constitute the ATP-binding domain, interact with the MRE11 homodimer.
Sequence:
MAKFLRLHIRGIRSVGDEDHDVHKIDFLSPCTLISGPNGTGKTTTIEALNFVTTGQMPTQKKQNFIHSTDVARKTRVDASVTLEFIDVKGRECTAVRRLVVTSGTKAAALAEEHTLAIKYPDGTVNTLSSKVCDFNTALLKHLGVPRAVFKYVIFCHQEDSTWPLSEPKELKKRFDDIFQLTKFVKAQERMKKIVLDFKKEMQTHEMSKQLYETHVRDKLVARQNQEECERKISKRKEETDELKERKANGQKKIEEMRTSIHELEDTLTSFKKTELERQNLKKQLSLIRVEPYFGTEEELKREIEEFRGSEGRSYGEERARIQKKIGKNNQERQELSQKKTEFENRISSLKAEVIHCQSLKYDLERLENQLRSELDLEHDADIDIEIDNAITLKIRGMSDKARMIAKNCAELQSNLRTAQEAATKIEVEMKTLQNEKVKLEKEVEQLKFKIKQGQNATAGMKDLLKKEEALRKSLADLPLLDENALTECKLKREKYLKQLDILKKKCAEAEKNAEKDREKESLKQTLSIARKKMTAYQRIYDNNWQGLIGQAPDFPWTPILSKTFHKLRNDKKIMEEDLRDVQLNVQKLETMQHQYRKQEESLTAQELKLSENIFEACSCEAEEVSEKLENLRKRLKKARKDLAPLSAKSNLYDSYIEESKSSGCCPLCDRDFKTKKEINEFSKKLENMTLSFPTEQEELEKLVSKLEKEEIIIVKAEGQANELQRIVKELKEVREKNRKLSTEMAEEKSNLSKNEKQLETVNAKLKLAEDLQTDVGVIQQLYEQTEENEKRYEQLVSESDSSDGLSYTELRKKVEDKDEEYRKIVQEGEELQKCSEERNKLQSKLNELGTHRVSLGEAAAQAGAFAEQLETKIKEIQECITAISQKRNEDLPDAQFKKDDLTRNVSSKEEEKKKAEMEVQMMKKELDQKIFHRKSLFKKVQEGGLCERQLMDKENNIATLNASLEENQQRQKRFEEDLRSFDSSHQRESILKDQLTRMIIENKIKELKRTLATFDGQINEDRITEQKQAYNKLQNELRLIGNEEVKIYTQMQEYEKQKKIAEAKLSTKECQNAESNYRDAIIELAITKESISDLTKYRNCLDASLIQFHSEKMGRVNGIIDDLWRKVYNSTDITTIRIRSDATSETSSKKVAYEYNVMMVHETGTEVEMRGRCSAGQKMLASLLIRIALAEVFGGSCSMIALDEPTTNLDESKVEGMAIVLADIIAERRGFDENGKLRGRDMQMVVITHDERLVNRITISCRPEYIYCLGKDEHGISFLSKRYPDGTVKRVNTKRRF
The following text describes a protein:
Function:
Probable 2-oxoglutarate-dependent dioxygenase that may be involved in glucosinolates biosynthesis. May play a role in the production of aliphatic glucosinolates.
Sequence:
MGGNETQELPVINLSDKNLKPGTELWNSTRNSVREAMEHHGWFVAEYNSFPAELHKSVLEASKELLDLPPEVKVTNENHKAGHGYITMISDDQPVHEGLGIDQANDIQQCRQFSRLMWPDHHDNDRFCEIVNAYAKMQAELEQLVIRMLFESYNLERYTEKHIRGSRYLLRLLKYRRLPNGEPNRKFISHTDKSFISILHQNHITGLMLKSEKEDVWYPFIPSPTRFAVIAGDAIMAWSNDRIKSCYHKVEMESVEMRYSFGFFSFQEEMISTPEEMVDKDHPLAYKPFNHDGLLAFYETVDVHLKAHRTMTKVYCGIQQAHEP
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MPPKGSRKSAVAAPSKTLVLDNGAYAIKAGYVPSASEAPTYDDCRVIPNCIARSTRDKCTYVGSDLDGCKDFGELAFRRPVEKGFIVNWEAEKAIWEHEFMEAAVVEGFRVVWTVPDHWQCDPKETNLLLTEKPNCPKELQKNCDEIVFEQFEFASYYRCVGPRLNAYHPASPESLSSLPQECLLIIDTSYSDTTILPLYSGRLIQSAVRRLTVGGKLLTNYLRELASLRHYNLMEETYLLNEIKEAVSYVAPSAQHFSRDLERAWKGRLGNKRELDSSVVVDYVLPDYETAIHGHARPHDPAKSRMRRGLQPLQGPREDLLTMGNERFAVPELLFNPSDIGIQESGIPGAVMESLSGLPEALKVGMLSNVVVVGGNSLIKGFIERLEDELRAIVPAQYLLNISARVAEGGIGDKGRFGAFVLLIGQCAAGALARFPSALLENFRALSHLYISISMRRIPRPSRAIDPSTVLHSAVRPRISPPSCHCIRTSTAAFSSTPSNGFLLPAKQDKKKHQQFVRRWQKRLLGDSEPIGAHVDPYDPTSPVRIAPEEQGEYEEVLDEEGGKNEVLQQGRLKGLEADTYIPVEESGRSRPGADLLHVGGEEWLQQKVEADMAREYEKLTMRTYTPMTLGMANEIESLTGTPYTLRDDNLMMAQATHDVTARPYTSYKKLTRPEDLRARFAQAVAEVYALKEADLDLNLAKLPNRGIYDVPRWVKDIKLQKVKSGGLTLRYPGNKSAKDFLEAMQSAPEWESAAVEGDELLVEGAEDLVEPVLPADALPTMDPATPAFKREAVVKIDPEKKPFDFMSNRPVPRTKPAEPTKVEEVLEVEIPTAEPVDSTPSRRVLQPVADHLTGSPIPKPPNKSTPSKIQLEEVQWRHAPIDNNAIKFALFKRVFQLMGIRISDPHLTSSTTIGQLYDHVYEAAKPQPTSLYSAIHIEGANARRRAKRSDNPNPSRSQRRADLGDLITAGNVQLRKNRPTKMEIRTKTGQAKSITQGTRDIPDFGKPLSSKSVNYLIEHRKKDAKKQEAAEVEKMGQRWGVRIPKT
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.
Sequence:
MNLYGIEIDDLLYKHFLEFLSDAEIDSLFRSITTPPPRYYIRVNTLKISPRELVKRLNSRGLAVYRDEYIDDALWVPVEGPFKIPTAKKVVVVDKKAAESVMLGADLYAPAVIKTDRVNIGDEVNIVSDNGRVVALGVAVMDSDEALKARRGLYIKVEKSLYRTPKLRNLPEYAEGLFYSQSLPAILVGHIARRITQTDAVDLNSAPGGKTTHLAQMGIRVIAVDRSAQKIEKLRSEAARLGLDVFIDILLHDSRYLDRDFPKIKAGVALVDPPCTDIGVRPKIYHKVTFEAAKTLARYQIQFLKTALKIAPYVIYSTCTLTYIENEGVIEKAGAEIVDAGIEIGAPGWGCRECRRFLPHVHNTPGFFIAVLRGARKEP
The following text describes a protein:
Function:
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MHSFGHRANAVATFALTILAAMCFAASFSDSFNSPTPTASVKILNINWFQKEANANDEVSMTLNISADLSSLFTWNTKQVFVFVAAEYETPQNALNQVSLWDGIIPAKEHAKFLIHTTNKYRFIDQGSNLKGRDFNLTMHWHIMPKTGKMFADKIVMTGYQLPEQYR