lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transfers an acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate producing a lysophosphatidic acid (LPA), an essential step for the triacylglycerol (TAG) and glycerophospholipids. In vitro also transfers an acyl-group from acyl-ACP to the LPA producing a phosphatidic acid (PA). Prefers arachidonoyl-CoA as the acyl donor. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
METMLKSNPQMQQRNNHSGQETSLWSSGFGMKMEAITPFLGKYRPFMGRCCQTCTPKSWESLFHRSIMDLGFCNVILVKEENTRFRGWLVRRLCYFLWSLEQHIPTSSDASQMIMENTGVQNILLGKVPGAAGEGQAPDLVKKEVQRILGHIQTTPRPFLLRLFSWALLWFLNRLFLNVQLHKGQMKMVHKAAQEGSPLVFLSTHKSLLDGFLLPFVLFSQGLGVLRVALDSRTCSPALRALLRKLGGLFLPPEANLSLDSSEGILARAVVRATVEQLLTSGQPLLIFLEEAPGYPGPRLSALGQAWLGLVVQAVQAGIVPDATLVPVATAYDLVPDAPCNMTHDLAPLGLWTGALAIFRRLCNCWGCNRRVCVRVHLAQPFSLQEYTINARSCWGSRQTLEHLLQPIVLGECSVVPDTEKEQEWTPPTSLLLALKEEDQLLVRRLSRHVLSASVASSAVMSTAIMATLLLLKHQKGVVLSQLLGEFSWLTEETLLRGFDVGFSGQLRCLAQHTLSLLRAHVVLLRVHQGDLVVVPRPGPGLTHLARLSMELLPTFLSEAVGACAVRGLLAGRVPPEGPWELQGIELLSQNELYRQILLLLHLLPQDLLLPQPCQSSYCYCQEVLDRLIQCGLLVAEETPGSRPACDTGRQHLSAKLLWKPSGDFTDSESDDFEEPGGRCFRLSQQSRCPDFFLFLCRLLSPILKAFAQAATFLHLGQLPDSEVGYSEKLLQFLQACAQEEGIFECADPNLAISAIWTFKDLGVLQQIPSPTGPQLHLSPTFASRDNQDKLEQFIRQFICS
The following text describes a protein:
Function:
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIIIITSVISFLLGSIPTGYFITKKACGIDIRTKGSGNIGSTNVKRIVGTKISIITQIIDVLKGIIPVVLGISLSKIVKLPVSTDTYLSIIAIAAILGHDYTPFLKFKGGKGVNTTLGVFIFIAPIPTLTGLAVYFILGLFIRIVSIRSISIGITIPIMCIITKLPIQIIISTTIACILMIIRHKDNLVRLIRGEEK
The following text describes a protein:
Function:
Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.
Sequence:
MKRKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQDTPRFQQLLGDGSNWGLDLQYAVQPSPDGLAQAFLIGESFIGNDLSALVLGDNLYYGHDFHELLGSASQRQTGASVFAYHVLDPERYGVVEFDQGGKAISLEEKPLEPKSNYAVTGLYFYDQQVVDIARDLKPSPRGELEITDVNRAYLERGQLSVEIMGRGYAWLDTGTHDSLLEAGQFIATLENRQGLKVACPEEIAYRQKWIDAAQLEKLAAPLAKNGYGQYLKRLLTETVY
The following text describes a protein:
Function:
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Subcellular Localization:
Cytoplasm.
Sequence:
MVAMTKRVKVFEIAFNDPSKTFYCSGDKVAGKVLVEVSEVTRVMAMKVLGVGCAKVEYAKGKQRCREEVDYLKYEDVVQLDEHPTDNDGSVILRPGNKYEYSFGFELPAQGQLVSSYKGKFGFVQYYVKALMERPCQPALECKKHFEVEEPLDVNTPDLLSPTGGMKEKKVTCMFIPDGQVSLNAKIDRRGFCEGEEICIDAKFENTCSRIVVPKAAIVAKQTYQANGRTKVFRQKLSSVRGNHIISGMCDAWQGKSIRVPKIKPSILGCNIIRVEYALMIYMHIPGSEKLILELPLVIGTVPYNGFGSRTNSMSSQDGSISNASNSWVSLRMPSSAPPSYCDITRDCCIDQPLTPLLDDYDGGDSPIFMNAAQFQFPPLPAYSEVEEEFNANARMLPVC
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Sequence:
MALKLSYFDIRGLAEPVRLLLVDKQVAFEDHRIARDQWAEIKPKMIFGQVPCLLSGDEELVQSGAILRHLGRVHGLNGNNETETTFIDMFYEGIRDLHNKYAQMIYGNYENGKDAYIKDTLPGELARLEKLFRTYKNGEHYVAGDKESYADYVLFEELDIHLILSPTALDATPVLKKFHERFAERPNIKAYLNKRAAINPPVNGNGKQ
The following text describes a protein:
Function:
Mitophagy receptor that tethers atg8 to the mitochondrial outer membrane to promote selective autophagy.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type IV membrane protein.
Domain:
The atg8 interacting motif (AIM) is required for the interaction with atg8. The AIM motif is required for atg43 function as mitophagy receptor.
Sequence:
MSSESKGIPIPRSDSNKTSDVSSWEEDYELISLGSSQDALQRSGIRSAHGDSGYASSPLRMEHLSSSTIIINNQLKKIDVNESIPENSTLHNKYELGAVESSTSSLSLLQSKEEDDSSNWETEDSESAVEEAELPTIFEGKTVISPSSSGTDHSEAVEYTVPTAPPIPDLRFQQSYLQSIQRANGSAFLVALITLRDHVLYPFLSGGMWVFVRHIFQFLKLQEKGFHFGQSLRRNLGLFSTFKD
The following text describes a protein:
Function:
Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.
Subcellular Localization:
Nucleus.
Domain:
NFRKB seems to be mostly disordered. The wing-helix like domain doesn't bind DNA.
Sequence:
MDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQEVLSDSQREHLQQFLPQFPEDSAEQQNELILALFSGENFRFGNPLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLNSQQQYFHRLLKQILASRSDLLEMARRSGPALPFRQKRPSPSRTPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSWLPSSPARSPSPAVPLRVVPTLSTTDMKTADKVELGDSDLKIMLKKHHEKRKHQPDHPDLLTGDLTLNDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKKIKTIKSEAEDLAEPLSSTEGVAPLSQAPSPLAIPAIKEEPLEDLKPCLGINEISSSFFSLLLEILLLESQASLPMLEERVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFQLWLETKDQAFCKQENEDSSDATTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKALQQKPKPPSKVKSSSKESSIKVLSSGPSEQSQMSLSDSSMPPTPVTPVTPTTPALPAIPISPPPVSAVNKSGPSTVSEPAKSSSGVLLVSSPTMPHLGTMLSPASSQTAPSSQAAARVVSHSGSAGLSQVRVVAQPSLPAVPQQSGGPAQTLPQMPAGPQIRVPATATQTKVVPQTVMATVPVKAQTTAATVQRPGPGQTGLTVTSLPATASPVSKPATSSPGTSAPSASTAAVIQNVTGQNIIKQVAITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRITPDMMATLAKSQVTTVKLTQDLFGTGGNTTGKGISATLHVTSNPVHAADSPAKASSASAPSSTPTGTTVVKVTPDLKPTEASSSAFRLMPALGVSVADQKGKSTVASSEAKPAATIRIVQGLGVMPPKAGQTITVATHAKQGASVASGSGTVHTSAVSLPSMNAAVSKTVAVASGAASTPISISTGAPTVRQVPVSTTVVSTSQAGKLPTRITVPLSVISQPMKGKSVVTAPIIKGNLGANLSGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ
The following text describes a protein:
Function:
Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.
Subcellular Localization:
Nucleus. Note=Sumoylation does not affect nuclear localization.
Sequence:
MEAEETMECLQEFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEIEGVSKMAFRHLIEFTYTAKLMIQGEEEANDVWKAAEFLQMLEAIKALEVRNKENSAPLEENTTGKNEAKKRKIAETSNVITESLPSAESEPVEIEVEIAEGTIEVEDEGIETLEEVASAKQSVKYIQSTGSSDDSALALLADITSKYRQGDRKGQIKEDGCPSDPTSKQVEGIEIVELQLSHVKDLFHCEKCNRSFKLFYHFKEHMKSHSTESFKCEICNKRYLRESAWKQHLNCYHLEEGGVSKKQRTGKKIHVCQYCEKQFDHFGHFKEHLRKHTGEKPFECPNCHERFARNSTLKCHLTACQTGVGAKKGRKKLYECQVCNSVFNSWDQFKDHLVIHTGDKPNHCTLCDLWFMQGNELRRHLSDAHNISERLVTEEVLSVETRVQTEPVTSMTIIEQVGKVHVLPLLQVQVDSAQVTVEQVHPDLLQDSQVHDSHMSELPEQVQVSYLEVGRIQTEEGTEVHVEELHVERVNQMPVEVQTELLEADLDHVTPEIMNQEERESSQADAAEAAREDHEDAEDLETKPTVDSEAEKAENEDRTALPVLE
The following text describes a protein:
Function:
Participates in the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi. Catalyzes the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine). Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures (By similarity). Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction (By similarity). They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions (By similarity). They are required for instance in the proper development and functioning of the nervous system. As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway (By similarity). They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope (By similarity). The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (By similarity). Catalyzes the synthesis of xylosylceramide/XylCer (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) using UDP-Xyl as xylose donor (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The D1, D2, D3, (Q/R)XXRW motif is a critical part of the GCS active site, involved in catalysis and UDP-sugar binding.
Sequence:
MALLDLAQEGMALFGFVLFVVLWLMHFMSIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIEVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPAYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTERVGLVHGLPYVADRQGFAATLEQVYFGTSHPRSYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWKFSMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRAGRYRLRCGGTAEEILDV
The following text describes a protein:
Function:
Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself) and represses transcription of acid-expressed genes. Specifically recognizes and binds the consensus sequence 5'-CCAAGAA-3'. Required for the control of alkaline pH-induced filamentation (dimorphic switch) and virulence.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNYNIHPVTYLNADSNTGASESTASHHGSKKSPSSDIDVDNATSPSSFTSSQSPHINAMGNSPHSSFTSQSAANSPITDAKQHLVKPTTTKPAAFAPSANQSNTTASQSYTQPAQQLPTQLHPSLNQAYNNQPSYYLHQPTYGYQQQQQQQQQHQEFNQPSQQYHDHHGYYSNNNILNQNQPAPQQNPVKPFKKTYKKIRDEDLKGPFKCLWSNCNIIFETPEILYDHLCDDHVGRKSSNNLSLTCLWENCGTTTVKRDHITSHLRVHVPLKPFHCDLCPKSFKRPQDLKKHSKTHAEDHPKKLKKAQRELMKQQQKEAKQQQKLANKRANSMNATTASDLQLNYYSGNPADGLNYDDTSRKRRYENNSQHNMYVVNSILNDFNFQQMAQAPQQPGVVGTAGSAEFTTKRMKAGTEYNIDVFNKLNHLDDHLHHHHPQQQHPQQQYGGNIYEAEKFFNSLSNSIDMQYQNMSTQYQQQHAGSTFAQQKPTQQASGQLYPSLPTIGNGSYTTSGSSHKEGLVNNHNGYLPSYPQINRSLPYSSGVAQQPPSALEFGGVSTYQKSAQSYEEDSSDSSEEDDYSTSSEDELDTLFDKLNIDDNKVEEVTIDGFNLKDVAKHREMIHAVLGYLRNQIEQQEKEKSKEQKEVDVNETKLYPTITAF
The following text describes a protein:
Function:
Member of the two-component regulatory system DltS/DltR. Regulates the expression of the dlt operon.
Sequence:
MKILIVEDEEMIREGVSDYLTDCGYETIEAADGQEALEQFSSYEVALVLLDIQMPKLNGLEVLAEIRKTSQVPVLMLTAFQDEEYKMSAFASLADGYLEKPFSLSLLKVRVDAIFKRYYDTGRIFSYKDTKVDFESYSASLAGQEVPINAKELEILDYLVKNEGRALTRSQIIDAVWKATDEVPFDRVIDVYIKELRKKLDLDCILTVRNVGYKLERK
The following text describes a protein:
Function:
Positive transcriptional factor that acts as a component of the stress responsive system. Recognizes and binds to the stress response element (STRE) which is involved in the response to various forms of stress (heat, oxidative, osmotic, etc.). Involved in the regulation of the CTT1, DDR2, HSP12 genes. May be regulated via WHI2-PSR1 complex phosphatase activity.
Miscellaneous:
MISCELLANEOUS: Present with 125 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The 9aaTAD motif (residues 261 to 269) is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MTVDHDFNSEDILFPIESMSSIQYVENNNPNNINNDVIPYSLDIKNTVLDSADLNDIQNQETSLNLGLPPLSFDSPLPVTETIPSTTDNSLHLKADSNKNRDARTIENDSEIKSTNNASGSGANQYTTLTSPYPMNDILYNMNNPLQSPSPSSVPQNPTINPPINTASNETNLSPQTSNGNETLISPRAQQHTSIKDNRLSLPNGANSNLFIDTNPNNLNEKLRNQLNSDTNSYSNSISNSNSNSTGNLNSSYFNSLNIDSMLDDYVSSDLLLNDDDDDTNLSRRRFSDVITNQFPSMTNSRNSISHSLDLWNHPKINPSNRNTNLNITTNSTSSSNASPNTTTMNANADSNIAGNPKNNDATIDNELTQILNEYNMNFNDNLGTSTSGKNKSACPSSFDANAMTKINPSQQLQQQLNRVQHKQLTSSHNNSSTNMKSFNSDLYSRRQRASLPIIDDSLSYDLVNKQDEDPKNDMLPNSNLSSSQQFIKPSMILSDNASVIAKVATTGLSNDMPFLTEEGEQNANSTPNFDLSITQMNMAPLSPASSSSTSLATNHFYHHFPQQGHHTMNSKIGSSLRRRKSAVPLMGTVPLTNQQNNISSSSVNSTGNGAGVTKERRPSYRRKSMTPSRRSSVVIESTKELEEKPFHCHICPKSFKRSEHLKRHVRSVHSNERPFACHICDKKFSRSDNLSQHIKTHKKHGDI
The following text describes a protein:
Function:
Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion (By similarity).
Subcellular Localization:
Nucleus speckle. Cell junction, desmosome. Note=Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein (By similarity).
Sequence:
MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRRGFSDSGGGPPAKQRDLEGAVSRLGGERRTRRESRQESDPEDDDVKKPALQSSVVATSKERSTERPLFQDQNTDEKETPERPGPIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLEQKVELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPAPKLIEESQRKTNALFEGRRIEFAEQINKMEARPRRQSMKEKEHQVVVRNEEQKSEQEEGKVAPRTRVMLRALDDLVARVGTPSPRRGSGEEEEKEIPIVHSDAEKEQEEEEQKQEMEVKMEEETEVRESEKQQDSQPEEVMDVLEMVESVKNVIAEQEVMETNQVERVEPSENEASKELEPEMEFEIEPDKECKSLSPGKENASTLEMENEPEEKEEKESEPQPEPMAQPQAQSLPQPQPQRHRQSQSQPQQYSSPPPLSQPETLPLAVSQPPPQLIQRQGHLPPERKEFLVESVKLTEVPTEPVLTVHSESKYETKTRSRSRGRARNRTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRTSSSSSSTSGSSSRDSSSSTTSSSESRSRSRGRGHNRDRKHRRSVDRKRRDASGLERSHKSAKGGSSRDAKAVSSSGMPRFKPGQL
The following text describes a protein:
Function:
Putative deacetylase.
Sequence:
MVAIIYSAEFLRHETGPTHPECPARLTAIATALRKMPGANYLHWQKPSPVTWNLDPYILRCHSQEYLNKLAKLAELGGGSLDADTPVSPQSYDVARLAVRAWLDGVDHVLNQREAVFVLARPPGHHAIRNTGMGFCLLNNVAIAAHYALTRPGVERVAILDWDVHHGNGTEALVDHNPRIFYCSLHQFPCYPGTGAAGDRGQHDNVLNIPLKPGGDGKVYREAFEHKVLPFLRQVKPDLLLVSAGYDANHSDPLAYMNLIPEDYGMMTHYLMEISPYPVLGLEGGYHLPSLAKSVVETLKPLLF
The following text describes a protein:
Function:
Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro (By similarity).
Subcellular Localization:
Secreted. Note=Massively secreted in the serum of EBV-induced nasophyryngeal carcinoma patients.
Sequence:
MARFIAQLLLLASCVAAGQAVTAFLGERVTLTSYWRRVSLGPEIEVSWFKLGPGEEQVLIGRMHHDVIFIEWPFRGFFDIHRSANTFFLVVTAANISHDGNYLCRMKLGETEVTKQEHLSVVKPLTLSVHSERSQFPDFSVLTVTCTVNAFPHPHVQWLMPEGVEPAPTAANGGVMKEKDGSLSVAVDLSLPKPWHLPVTCVGKNDKEEAHGVYVSGYLSQ
The following text describes a protein:
Function:
Promotes the exchange of Ras-bound GDP by GTP (By similarity). Involved in phagocytosis, fluid-phase endocytosis, regulation of macropinocytosis and control of cell movement.
Subcellular Localization:
Cytoplasm.
Sequence:
MVVILWGWNENRFNTLDQVISFDFIEENKKLYLKILENEKQQKIYNISNLIGRRMDNYRDNNNNNGNGSNINNNGIIINSSMGSQYFNLNKGIIIVESDNETFLIEEIDYLGKFPILKQFIKCEEFIGISTLEIISNIEKQLSNLVNLKSNTTEQTDRKYKTNLIDFKESIIQLEKDCKNLLKQSNLINPSIKYSVVKSVKFLLKEIKFEFYHGDINIKRIELFQQLKKFLKIHFWNNPNLILNSGSNIDMTDSNDSISSEEINSPNDLNLSLSSFPSISSPSNSSYNNINTLTFSNNNNNNNNNSNNNNNNNNNNNNNNSIINSNNNNNSNNNSNISNSSNNNNNNSNNSNNISINVSKTGNNSVINSPTQSSSCYIDCDDTMSNYTDCTNTTNTNSTTTTTTTTTTYGNNLNVYNNNNNNNTNNNNNNVPYKKPALKMMKSPSFKIQLIQEVYLEIMDQCKKIQNYLYELLDTYLTDEEYINNNNNNNNKDISILFENNTSYCIAQEIFISLIKNSNDFLYQVQLIDLTDTRKKSKELSEVSNQLFYSTQQLFPSISDHLDFIEMDIFTNNNTTTTTTTTTTTTNTTTNPSNTIKSSHSSLLSSSYSSSKDDDIVLTINKVLSKLDTFSKEYTKLIGNNLSSNYYVDSGNNNESVSSPKCGLFLSHSLSTDSPMTYVKRNTSSGSSASTSSYTTPVSSSASLSFSSSTQTPSSAASQHHIQQILQQQQQQQQQQQQQQQQQQPQQIQSQSQQQHQQQQQQQQQQQQQQQQQQQQQQQQQQQQIQSQSQQQQQLNRKPHYSSISPTSMLVYNATGGKFGVVNQNNNSAESTPTFQLNTMDILNSLMGKEGQNSNTNNANNPNNNNNNNNNNNNNNNNNNNNNNNNENKNENKNETNKSGHNYNNSSTSTLSSSTTIGDLANVSSTNSPNSSTPNLLLPPHQFHNHNREYNHSHHHLLSSSSNNVMINNRSIGKSFSTGNFSQPQPIMPSNGIGGSGGGGLGTTLSVGNGGIVGGLQSRSSSFEENQLQYAIESFMEVYNHLTSKDKVDTSIWLEEEKEDINVYYINNTNIDDKFYRSIKYASLNQLILKLTCESNTELRFTKTFITTYRSFTTGDIFLMKLIQRYFTPNLKNIVPYQFVQKIQIPIQLRVLNVLRLWIEQYPSDFQQPPQITTQSTQPIQNSTTQPQPQPQPQQPQPQLQQSTNLQNSTIQQPSLFKMLTAFLNSTRRNGHGQYSDLILKKFKQQKQKDRLQLPIINNGQGIPKAKIFWMKYSTEFIFSQSSTDIAEQLTLLDFDSYKSIEEIELLNQAWSKPDQKTNTPNIASMVNRFNSFSSFVSWAILRENDIKQRSKMMLKMIKICYALYKLSNFNGLLAGLSGLMASGVYRLNHTKSLISKQYQKKFDFLCKFLDTKKSHKVYRDIIHSTCPPLIPYLGIYLTDLTFIEDGNQDEIKGLINFKKREMIFNTILEIQQYQQQGYTIKPKPSVLGFLCELPHMSDKKKFEDDTYEQSILLEPKNSTKLEVMNAKK
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MAKKVLGFAQLATLIVVLSPSSIYANVGPGDNAAEFTTLCQLISLAEGAAQPPAATTAPSAEYDELMRLNMTLSDEAWHDMFIKSKADKTWHDAIPATAKDPGGWAEAWPTWRKAAEELTQEDKMANIKSLNVNAANPKQKAMIITEIRKMADAAQELMKKRHTLDKSIEKPPQEYAAALKTLAYGDKTKNRKTVTAADAFKGGSTSFSTDCGGAAASNKIKTVAATITCLCHKANTQNEDQVCGRTVKITTNTWTVNGAIGSAGVITEPLGFCSVEQGTDLTSSEITAILRQLKSLIKVTSNDGILGASDNGSCDADKTHGICIKLTNWAADGKVDITKLEWAKQAVELAKELSRREHAAASAAEIDSAIRNLHRQAFRTTLYTAHIQHNPHQTATPLDSTSKNDKGMEDKKKECEKHKNNKTSCTNAKCIWEGKDGKSDTEGECKPKDGGKGTAQTNAGTGDGTAGTGPNCASQTKKEDCEKENVGKTTPVCGWRIGKDNEPDKDKEMCRNGSFLVNKQFALSVVSAAFVALLF
The following text describes a protein:
Function:
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. Presumably responsible for energy coupling to the transport system.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MLATSDLWFRYQNEPVLKGLNMDFSLSPVTGLVGANGCGKSTLFMNLSGLLRPQKGAVLWQGKPLDYSKRGLLALRQQVATVFQDPEQQIFYTDIDSDIAFSLRNLGVPEAEITRRVDEALTLVDAQHFRHQPIQCLSHGQKKRVAIAGALVLQARYLLLDEPTAGLDPAGRTQMIAIIRRIVAQGNHVIISSHDIDLIYEISDAVYVLRQGQILTHGAPGEVFACTEAMEHAGLTQPWLVKLHTQLGLPLCKTETEFFHRMQKCAFREAS
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity). This sigma factor is involved in regulation of cellulosomal genes via an external polysaccharide-sensing mechanism. SigI1 promotes transcription from sigI1 and celS promoters.
Subcellular Localization:
Cytoplasm.
Sequence:
MEVRKINTHNREKKLDDIVYDDFISTLRQIKEGNHQLREEFISEYKPFILKVTSNATGKYIDTRNSDEFSIALSAFNEAIDKFDIEKGYNFFLFSEQVIRRRLIDYSRSNKDDKEYPFSFFDDEYFYNNEKLLSKSYIGFEDIEAREDIEELKKKLQEFGITFLDLVLNVPKHRDSRQLCIRLAKMLAEDEQMYNALMKNKNIPRNELKKKAKVHGRTIGNNRKYIIALCLIFRSNLNLSKRYLEYYTMDGESDLI
The following text describes a protein:
Function:
Catalyzes the reversible aldol condensation/cleavage reaction between glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (DHAP) to yield fructose-bisphosphate (FBP).
Subcellular Localization:
Cytoplasm.
Sequence:
MTDIAQLLGKDADNLLQHRCMTIPSDQLYLPGHDYVDRVMIDNNRPPAVLRNMQTLYNTGRLAGTGYLSILPVDQGVEHSAGASFAANPLYFDPKNIVELAIEAGCNCVASTYGVLASVSRRYAHRIPFLVKLNHNETLSYPNTYDQTLYASVEQAFNMGAVAVGATIYFGSEESRRQIEEISAAFERAHELGMVTVLWAYLRNSAFKKDGVDYHVSADLTGQANHLAATIGADIVKQKMAENNGGYKAINYGYTDDRVYSKLTSENPIDLVRYQLANCYMGRAGLINSGGAAGGETDLSDAVRTAVINKRAGGMGLILGRKAFKKSMADGVKLINAVQDVYLDSKITIA
The following text describes a protein:
Function:
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
Sequence:
MLKSDVVLLLYILIINLICCLNGNSKKRAYILNTPKSSNCKRSSFRRWNNPVNNNNSQILSKNEGSIEDVYNKKISGRCNIKNFSKDINNNIYIETNRRERRIKRNKYLLSLYNNTNIKTSNFIYPLFIHEEDVEKKHTQLEGIYTYNVDGIIKEIEECIKLNIHHFMFFPVIREENKTVYCEESYNENSYFCKTISRIKEKFSDDIIVYTDVALDPYNIYGHDGIYDDNKKEILNDITVHTLVKQSLCLAKSGADVVCPSDSMDKRIELIRKNLDFHNFRDILILSYTCKYSSSMYKPFRSILNSNILKNFVKNKQSYQHDFNSYMDLNNVDKHIIEGADIIMVKPSMFYLDIIHKIKNRIKDDVQIPIAVYNVSGEYMMIKNYVKYLNEDINYENEIITELFKSYLRAGANIIITYFAKQYGLYMKKLYDKNIIIDDNSNNNFNIELTL
The following text describes a protein:
Function:
Has a role in the negative regulation of gluconeogenesis. Imports fructose-1,6-bisphosphatase (FBPase) into the intermediate vacuole import and degradation (Vid) vesicles. This is an indirect role and requires cyclophilin A.
Miscellaneous:
MISCELLANEOUS: Present with 2950 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Nucleus.
Sequence:
MRAMDTQVQSAERGLVLPPMNSTVSSATAATTATNTDTDTDGDRDEERESLAEDGSEWVPAYMLTRDRSRYLGHFLGVDKMLEAVKCKYCGVIIRRQGNSISMAEASQTHLWSTHKIDPNANYYSGWTGVEAGSTFMVRPPLKNHQGGSATTNSIANLLEIDEDFLKRTREKEMALPLVQSLAIIIASENLPLSFVDNTAVRLLINQNANSLSFIDHDLILNAIRSIAYNLDRIIQRTALRNNSDLSLIIDKNYLLMDPTDRSNQLSNRLKNQLFEMQKINFFSLSHSVWNNTISILSIQYYDDFHSQVKTLPLIIQNLHEYNNDPKLSIPAQLLKISQELPGLQNTVISITLPRSQIVDLLNVMDSQPFFPNTYTNAKNYYHNCIISIINSAILPLFGTPKSADITHPRQSSFSKEPLTLLDSLIDLSNIDISNSIFSRINSFLDDLQSNSWQLDKFRSLCEKFGFEFVCSKFDLSRYSTATVSLQTFLNLRPIIEEYQSSIQIEKFNEIDFQIIDYLLITLNSINRILKFFTSSKSLNFTYVLFAIMSIEKHLLSTLGSLQFQRLIAPFETFLSKIQEFKTILFSDDMNLLAMFLCPAILFEREVLEYSFHTISLSEIVDKLSTSIFSLLKRFLNLHTIGNVNNSHNTSNHSNMNIHTDNQTNNINNRSGNNSDNNDNEHDNDNDNHSNSNTPASRIDIDPTGGENSVLPEQQPQNSNNNLSFGSLSDTHHLSDSTISKEIDSIFLQIIQEDLYDYLSTVNSIVPISYRSYCEQSNFIRDSGRFKKRIITEDSIIGELEQPMNFIEELLDIHVPVCNAFWSQYLDNDAGPIIRILFKIMQCQSSSSIRGEYSFLNDFIPRVHPDLTQEIIKIKLFNDQFVASKVDYDLDTLQTASQYLP
The following text describes a protein:
Function:
Bifunctional enzyme; part of the cluster involved in the biosynthesis of biotin (also known as vitamin B8 or vitamin H), a water-soluble vitamin that functions as a prosthetic group of many carboxylases, such as acetyl-CoA carboxylase and pyruvate carboxylase. Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring. Also catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MAPVGAALWRSLRAHQVYGANTDVGKTIVSTFLCNAVNRLKNQGKSAFLKPVSTGPLDEADDRHLQRHAPNTLTKCLYQFDEPVSPHIAAKTFAIPRDDEILSSVHRTLSDWANDGVGFALVETAGGVHSPGPNGNSQADLYRPLRLPIILVADSRLGGISSSISAYESLLLRGYDVHSVLLFKDDYYQNHEYLGNYFRGKSIPLVPVPAPPRRPQEQDPDSRARDLEALDKYYSSVTKSTDVVSLLDELVLKNKQRVEYLDEMASRAQKTIWYPFTQHHGMAAKDITPIDSAYDDFFQTYVTADRSAQQGRLQATFDGSASWWTQGLGHGNPGLALSAAYAAGRYGHVMFPGNIHEPALALAESLLKTVDNPRLQKVFYTDNGSTGMEVALKMGLRAACDRYGWDASKEQINILGLKGSYHGDTIGVMDCSEPSTYNQRVEWYRGRGHWFDFPLVKMSQGVWQVEVPATLQASLGGNQQFSSLDAVFDVESRVRSDAGQRYRKYILETIERLVTQEGKKFGALIMEPIILGAGGMLFCDPLFQRCLADVVRGNPQLFNRGRLTEPQPQTDLSWSGLPVIFDEVFTGLYRLGRKSSASFLGVNPDIAVNAKLLTGGLVPLCTTLASNEIFNAFTSPEKRDALLHGHSYTAHAVGCQVALDSLRTMNNMDEDGSWNDFKNDWKQPHAGDTARVWSVWSHKLLHNLSHAESVDGVFAIGSVLSISLKDAEGAGYTSTAAKGLQTRLAAGGPQFNVHSRVLGNVLYLMSSVTSKQETLRTIEGILREALL