lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
A putative bidirectional acetate kinase that may drive flux through the ethanolamine (EA) degradation pathway under anoxic conditions found when this bacteria infects host intestine. It may generate ATP that can be used by other enzymes (EutA and EutT) in the eut pathway. Can use GTP instead of ATP with reduced efficiency. Overexpression in E.coli yields elongated protein sheets; prevents artificial BMC formation by eutS alone or by eutK, eutL, eutM, eutN, eutS in E.coli; Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon. EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection.
Subcellular Localization:
Bacterial microcompartment.
Sequence:
MKRIAFVGAVGAGKTTLFNALRGNYSLARKTQAVEFNDHGDIDTPGEYFSHPRWYHALITTLQDVDTLIYVHAANDKESRLPAGLLDVGTRKRHIAVISKTDMPDADVAATRQLLCEIGFREPIFELNGHDPQSVRQLVDYLAALSEQEEEAGEKTYHS
The following text describes a protein:
Function:
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.
Subcellular Localization:
Postsynaptic cell membrane. Presynaptic cell membrane.
Sequence:
MPEIIELNVGGVSYTTTLATLLQDKSTLLAELFGEGRDSLAKDSKGRYFLDRDGVLFRYILDFLRDKALHLPEGFRERQRLLREAEHFKLTAMLECIRSERDARPPGCITIGYRGSFQFGKDGLADVKFRKLSRILVCGRVAQCREVFGDTLNESRDPDHGGTDRYTSRFFLKHCYIEQAFDNLHDHGYRMAGSCGSGTAGSAAEPKPGVDTEENRWNHYNEFVFIRD
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTPSALRGRLASVDGAGPRQKRLDDVMTSLSKRPAAIRVVLPFVFRHWLNQPGRGLIVAGGLLGATVADLFMPVFSGHLVDALTRGSSDPDARHGALVAFGAIVALGAASVVLRLIGLQAIVPFTLKIMSDVAQGAFTRVQRFSTDWHANSFAGSTVRKITRGMWALDLLNDTILMALAPSLLVLIGSMVLIGLHWASLGAVIAVGALFYVAITVLFSTRYIAPAARISNAWDTKVGGTLADALTCNAVVKSFGAELREDTRLARVINRWRVRVRRTWFRYNYTAMAQLSLLLALRASVIGGSVLLWMSGHASPGDVTYVLTSYYVIHAYLRDVGMHINNLQRSVNDMDELVAIHDEPIGIVDAPDARPIAIESGEIAFDDVTFHYGGHRAPLYDGLSVTIRAGERVGLVGRSGSGKTTFVKLVQRLYDVSDGRVLIDGQDIAKATQQSLRSQIAIVQQEPILFHRTLAENIAYGRPGASLEAIEQAARLANAHDFILRLPKGYGTLVGERGVKLSGGERQRVALARAFLADAPVLILDEATSSLDSESEALIQQAMERLMKGRTSIVIAHRLSTVRSLDRILVFDRGEIVEQGTHAVLAGKPGGIYRGLFERQVVDLGHLAAAE
The following text describes a protein:
Function:
Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required. Required for normal motor neuron development.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MQVHERSHTGTHTFQCNHGNEKKAPAAGKVHSEGGSARMSLLILVSIFLCAASVMFLVYKYFPQLSEEELEKIKVPRDMDDAKALGKVLSKYKDTFYVEVLVAYFTTYIFLQTFAIPGSIFLSILSGFLYPFPLALFLVCLCSGLGASFCYLLSYLVGRPVVYKYLSDKAIKWSQQVERHRDHLINYIIFLRITPFLPNWFINITSPVINVPLKVFFLGTFIGVAPPSFVAIKAGTTLYQLTTAGEAVSWNSVIILMVLAVLSILPAIFQKKLKQKFE
The following text describes a protein:
Function:
Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach (Probable). Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular protons. Probably undergoes several conformational states in order to translocate the substrate across the membrane; keeps the substrate accessible to only 1 side of the membrane at a time by opening and closing 3 membrane-internal gates (Probable).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
Each subunit has 12 transmembrane (TM) domains, arranged with an internal layer (TM1, TM3, TM6, TM8 and TM10) surrounded by the outer layer (TM2, TM4, TM5, TM7, TM9, TM11 and TM12). TM1 and TM6 are interrupted by short, non-helical, Gly-containing loops in the middle of their transmembrane spans. Homodimerization is mediated by TM3, TM10, TM11 and TM12. Each subunit has a central cavity which binds substrates. Upon Arg-binding the N-terminus of TM6 and Trp-202 move to prevent Arg from return to the periplasm.
Sequence:
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVYAKMSFLDPSPGGSYAYARRCFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKDPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALIPIVGIAVFGWFWFRGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYVLSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKAGTPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIWAVVGSGAKEVMWSFVTLMVITAMYALNYNRLHKNPYPLDAPISKD
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MANNSNTVTRSFLQVASTEEVAPPLRVVQIEGLVILKIIKHCKEFSPALVTGQLLGLDVGSVLEVTNCFPFPIREEDEEIEADGANYQLEMMRCLREVNVDNNTVGWYQSTLLGSFQTVELIETFMNYQENISRCVCIIYDPSRSEQGVLALKALKLSDAFMELYRNNNFTGEKLRERNLSWVDIFEEIPIKVSNSALISAFMSELETDSPVTQCDYDRLQLSTNPFLERNVEFLVECMDELSIEQQKLGMVCNMTCKLPSFAVPILLSEPFTAASSAANMASEEKGCWAKLQPVVPDEGFTRQLMLIQAKSVLFGGSSLFENEKFWRERKLYTTDHYQPF
The following text describes a protein:
Function:
Non-discriminating glutamyl-tRNA synthetase that catalyzes aminoacylation of both mitochondrial tRNA(Glu) and tRNA(Gln) and participates in RNA aminoacylation for mitochondrial protein translation. Attachs glutamate to tRNA(Glu) or tRNA(Gln) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) or tRNA(Gln).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MAGMLREVCGAAASGLRVRFGPSPTGFLHLGGLRTALYNYVFAKQQRGTFVLRVEDTDQGRVVAGAAESIEDMLHWAGIPPDESPRRGGPFGPYQQSLRLDLYRAASEALLDRGAAYRCFCTPQRLELLRKEALRNQQTPRYDNRCRHLTPKEVAEKLAQGLDWVVRFRLERGVEPFQDLVYGWNKHEVAEVEGDPVILKADGFPTYHLANVVDDHHMGISHVLRGTEWLTSTSKHLLLYKAFGWDPPQFGHLPLLLNKDGSKLSKRQGDIFLERFAQEGYLPEALLDMITNCGSGFAEKQMGRTLEELISQFEIGRITTHSALLDLEKLPEFNRMHLTRHIENEGLRQKLIQELQLLVEDVYGDQEVDKEVLEKEYVEQVLLLRKGHISHLKDLVSDNYSYLWVRPSVSREQLQMISAEVDEIGKLVLGLMTKPAAVWTIEELNKDLRSLQKQTRETKYSSMMKLLRLALSGQQHGPSVAEMMVTLGPREVCGRISKVLSS
The following text describes a protein:
Function:
Part of the ABC transporter complex PotFGHI involved in putrescine uptake. Responsible for the translocation of the substrate across the membrane (Probable). Imports putrescine for maintenance of the optimal concentration of polyamines necessary for cell growth in the presence of glucose.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNNLPVVRSPWRIVILLLGFTFLYAPMLMLVIYSFNSSKLVTVWAGWSTRWYGELLRDDAMMSAVGLSLTIAACAATAAAILGTIAAVVLVRFGRFRGSNGFAFMITAPLVMPDVITGLSLLLLFVALAHAIGWPADRGMLTIWLAHVTFCTAYVAVVISSRLRELDRSIEEAAMDLGATPLKVFFVITLPMIMPAIISGWLLAFTLSLDDLVIASFVSGPGATTLPMLVFSSVRMGVNPEINALATLILGAVGIVGFIAWYLMARAEKQRIRDIQRARRG
The following text describes a protein:
Function:
Component of the MIS complex, a complex that mediates N6-methyladenosine (m6A) methylation of meiotic mRNAs and is required for initiation of meiosis, progression through the meiotic divisions and sporulation. In the complex, performs a scaffolding role stabilizing the other complex members.
Miscellaneous:
MISCELLANEOUS: Present with 486 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MQKCAGHAPLVTAASRVSQDTVDALLQAILKAYHKLASIDSHINDPVEIAFKLINSFKYLPISGSSVKDFESELRELDVFSPLLQSAVTAANNSNIIWDLIAVLFAYISIHKQLHPLILHNLNIWKDFMADNDEETATTTDGDSMNFGVLSLLSIVQNFEEITPNLFEFLKLGLRSTLLKIWVAQWQRYDPSATNLINGDEKISSWITKDYQVDFFIITSLASTSSLEVLPSHYFVYKISKRISHFPNLIDPKLYRSAISTIMENGISDNGGGENSSDKIDPTDLSFHLQVLMEVIDHPELNYLQENRLILLLDIALNYLILVPTHCLHSNFGELGSTQSLASTLNIIQFLLSKFLINMGSISQLINQYNRKCITTNNINNNNINNNGVINGSTNTTSTTTTTITNNNNNSNNSSISNNNRKIDWTQSYQTRYQIPYWFEDSILPPIPPISKSLFTFDKNLDHESDSIMIVNDVLRCLNLTILLISKLLRDYDDLKINPLIQSSDDHSNEDNHVIIEQYMQLYLVPLFTSLLLAQQLKDRGQERDEGHKEKEENINLIGSSSVKKLFSQLIFFSSLKLCENLVIKEKNLALYHLIKFATKVSLDDLILQKISINLLNHLFFHQIRDGSDDDNLIKKLCLKNQLSFQALKDYITLWNDGSEVYNAFYKELFYEEQPKIKPIKLTTSDLLKLFPEDVQFVISTPPNTITSASTSDNCTSSQSAAQKNIENFTTLSKYDVYSSTSFIPSTSKNTNTNVSKQQQQPQNSTPCSSNRFLFNKSSLISQESNGSNNNSGTQGPGSMNESYSLDNSFNTTNTNMTRQPTTLTRATDAMTTAPTTPIPYKNTSGSSNNNLWIESPMTNFKGSTISKSTNKSKMVNTGKNYILGGHNKVKNNSRAQSIHIDDFENENN
The following text describes a protein:
Function:
Receptor for basic fibroblast growth factor.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
TEYEFPVDNVWEFPRDRLHLKEILGEGAFGIVARAEALDINGCPGKSTVAVKMIKSGASDADLLNLVQEMTLMKMMGKHENVLSLLGCCTQNGPLYVIVEFALHGNLRDFLRKHRPKFICYDEVNGKKFSDTHLSFSDLLLYSLQVCEGANYLASKQCIHRDLAARNVLVCHNNILKVADFGLTRNMNSSDYYKKTTDGRLPVKWMAPEALFDRKYTTKSDVWSFGILLWEIFTLGGNPYPSVPIENLFSLLKGGYRMEKPPYASDELYQIMLECWTNEPALRPNFSSLLQSIQTLMCGSNLEVSVKHFVQPSLKCFCPIRF
The following text describes a protein:
Function:
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
Sequence:
MSTNTDDTTRTDGTFGDYGGQYVPEVLMPAVEELTDAYERYVLDNEDGFVDDFRQRIRSFGGRPTPLTHAPTLSQRHGVDVYLKREDLLHGGAHKLNNALGQVLLAKYMGKDRIVAETGAGQHGTATAMACAALEMPCEIYMGRTDVNRQRPNVFRMRLHDADVNPVTVGSGTLKEAINETMRDWATNVADTHYVIGSVVGPHPFPSMVRDFQAIISEELRAQSREQLGELPAAVIACAGGGSNTMGAFGAFVGSASLPGAPAGTHEPAPDVDLLAVEAGGSRLGVDDDAGYAPNSASLSTGTEGVLHGARTKLLQTETGQIVESHSVSAGLDYAGVGPELAHLVDTGRITPTNVDDDAALAAFHRLSRDEGVIPALETSHAVAALDQYDGDGPVVVNVSGRGDKDLDTVIEASAANDIDAAPDMEVFEQ
The following text describes a protein:
Function:
Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) by incorporating an acyl moiety at the 2 position. This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
Subcellular Localization:
Cell membrane. Note=Localized in the septal membrane.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVDVITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKEGEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLIIGEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL
The following text describes a protein:
Function:
May act as an effector for ARL3.
Subcellular Localization:
Nucleus. Cytoplasm. Cell projection, cilium, flagellum.
Sequence:
MAAEEEDEVEWVVESIAGFLRGPDWSIPILDFVEQKCEVFDDEEESKLTYTEIHQEYKELVEKLLETYLKEIGINEDQFQEACTSPLAKTRTSQAILQPVLAAEDFTIFKAMMVEKNTEMQLQAIRIIQERNGVLPDCLTDGSDVVSDLEQEEMKILKEVLRKSKEEYDQEEERKRKKQLSEAKTEEHPMQANETAKMSNSQGDGEHFAHPASGLKIPGFEHASMEGPIANLSTLRTEELRQREHYLKQKRDKLMSMRKDMKIKQNQTSEQKGKPAGEVEEMTEKPEMTAEEKQTLLKRRLLAEKLKEEVINK
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAAQFLLLLRRLYLTLYNWTVLFGWLKVLYLAVQTLRESGHEHVYDAVQRTLQLAQTAALLEIIHGLVGLVRSPISATLPQIGSRLYLTWGILWSFPQTQSHILVTSLVISWSITEIIRYSFFGMKEALGFAPSWLLWLRYSTFLLLYPTGIASEVGLIYVALPYIKASEKYCIRMPNQWNFAFDYFYGTIVVLGIYVPGSPHMYSYMLGQRKRALSKSKRE
The following text describes a protein:
Function:
Contributes to the RIGI-mediated inhibition of type I interferon production.
Miscellaneous:
MISCELLANEOUS: This protein is very unstable; MISCELLANEOUS: [Isoform F protein]: Produced by ribosomal frameshifting.
Subcellular Localization:
Host cytoplasm. Host cytoplasm, host perinuclear region.
Sequence:
MSTNPKPQRKKPNVTPTVAHRTSSSRVAVRSLVEFTCCRAGALDWVCARRGRLPSGRNLEVDVSLSPRHVGPRAGPGLSPGTLGPSMAMRVAGGRDGSCLPVALGLAGAPQTPGVGRAIWVRSSIPLRAASPTSWGTYRSSAPLLEALPGPWRMASGFWKTA
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MEESVIGIWCGKEIKEKSIKMKEEETDGMVLYIGSCIRIILSNSILEMGIEHNCLSVEQRENSFKIHFDKLYIFNHIPGIYGIIGLPLVLSVKKSGWRVPNFVYRSIQCLRKHDAIHTQGLFRLTCSIGELKPLKEIIDLDKDIGSNFSDDCIVIGTLLKSCLKLMIEPVIPFNKAIEFSQLKQNSNPKQFINSLPIPNQDTLYSSSIFTRNLL
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone; NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein. Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MNHFPIHGPFVAFLGLLCLVPPGAVAISWLLAPRTQGAEKRTTYESGIEPVGEAWIQFSVRYYMYALVFVIFDVETMFLYPWAVVFDRVGALALLEVCLFLFILLIGLVYAWRKGALEWL
The following text describes a protein:
Function:
Required in glia to regulate the acute sensitivity to cocaine and to continuously maintain the proper blood-brain barrier (BBB) function. A moody-mediated signaling pathway functions in glia to regulate nervous system insulation and drug-related behaviors (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSDETTGSLGDAFSPMDTPTTTIMPPPADVDESGFSHSLLTFAAVMTFLIMIVGICGNLLTVVALLKCPKVRNVAAAFIISLCIADLLFCALVLPFQGLRFVQGTWRHGEVLCRLIPFIQYGNIGVSLLCIAMITINRYVMITHYSLYNRIYKRHWIAIMIAACWLFSYGMQLPTLLGAWGRFGYDARLQTCSIMSDRHGHSSKTTLFITAFVIPCLVIIACYAKIFWVVHKSEQRLKRHATKQNSIPNNLRPLAAATSMPSGDGANPSQVPAGCRVSSDSSSNYSTDVPDTTPGGAGGGAGVKQQPSRVKDQREVRAKRNEWRITKMVLAIFLSFVICYLPITIVKVADKDVEHPSLHIFSYIMLYLSACINPIIYVIMNKQYRKAYKTVVFCQPAARLLMPFGKGNGASSAAEKWKDTGLSNNHSRTIVSQMSAGATATATATAAAGTQPQSTSTQGPVQALELTARVPDLISKSSNLPLPQPLPQIPPAGARPSLTPPPPPSVLTATHSNGSGSQRLPLKKNNHSYTNSGFNSSVISANPSSSPSPSSSGGGIYRPGIGSMGNGSASIRRITMVGDDIILEEEELPPTPTASSPPQMQAPPPPPSSSRQTTMNALNTTPKTPIYMNVDSPKRNQSYSERNIPVPAREGHDQGVKDSQGLPSKLMDKKKFPKD
The following text describes a protein:
Function:
Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol. Shows a preferential hydrolysis at the sn-3 position of triacylglycerol.
Sequence:
MGSALRAEMWLLILVVYLFQRNVNSARMPTKDVDPEAFMNISEIIQHQGYPCEEYEVTTEDGYILSVNRIPQGLVKPKKTGPKPVVLLQHGLLGDASNWISNLPNNSLGFILADAGFDVWLGNSRGNTWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTGQEKIYYVGYSQGTTMGFIAFSTMPELAGKIKMYFALAPIATVKHSKGPGAKFLLLPDMMIKGLFGKKEFLYQTRFLRQVFIYLCGQVIIDQICGNIILLLGGFNTNNMNMSRANVYVAHTPAGTSVQNILHWSQVLNSGELRAFDWGSETKNLEKGNQPTPVRYEVRDVTVPTAMWTGGQDWLSNPEDTKALLSEVTNLIYHKNIPEWAHADFIWGLDAAHRMYNEIIQLMKHEETNFSQGMCRARL
The following text describes a protein:
Function:
Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, and both D and L isomers of inositol-1-phosphate (I-1-P).
Sequence:
MENLKKYLEVAKIAALAGGQVLKENFGKVKKENIEEKGEKDFVSYVDKTSEERIKEVILKFFPDHEVVGEEMGAEGSGSEYRWFIDPLDGTKNYINGFPIFAVSVGLVKGEEPIVGAVYLPYFDKLYWGAKGLGAYVNGKRIKVKDNESLKHAGVVYGFPSRSRRDISIYLNIFKDVFYEVGSMRRPGAAAVDLCMVAEGIFDGMMEFEMKPWDITAGLVILKEAGGVYTLVGEPFGVSDIIAGNKALHDFILQVAKKYMEVAV
The following text describes a protein:
Function:
Catalyzes a reversible epimerization of GDP-D-mannose that precedes the committed step in the biosynthesis of vitamin C (L-ascorbate), resulting in the hydrolysis of the highly energetic glycosyl-pyrophosphoryl linkage. Able to catalyze 2 distinct epimerization reactions and can release both GDP-L-galactose and GDP-L-gulose from GDP-mannose.
Sequence:
MGTTNGTDYGAYTYKELEREQYWPSENLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEKEKAKGSDVSLYGSSKVVGTQAPVQLGSLRAADGKE
The following text describes a protein:
Function:
May be involved in the secretion of hexose transporters from the endoplasmic reticulum. Involved in secretion of GAL2 and HXT1.
Miscellaneous:
MISCELLANEOUS: Present with 21400 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MEIYIRLNADVEHDYAFQVSNEDTINNKIKKIFPSKTGLADLMVLRPSIFHEKEPVKFYKSIHPGYLSEGGCLMFHYEADNEENLEELNDSKPLIDQLWPGQLVVPEWKLSKKNIWVYTIIMLAWLYTDLPDAISPTPGICLTNQLSRLLIPVAKHMDLPEIAAKLEQEVQANYSSLVAQWLFFVMHIFKVGIITLFLKLGIANPISFNPYKLWSLRDLTSPSANGAKNSGGNNNTTDLKTRLRSLGWIGAKRATYDDYQTNYYNYVIDKMGGAVAAYRAGAIRKAAAPGIQLVAGEGFQSPLEDRFTASTFTAIKTERKFILSEEYFVELENNLKKILEEYDGDIGKMNAEIRRFRRFGIYEPDEKLASLVKLRREIADEKEKASNNDATFGIKKNDLKKSN
The following text describes a protein:
Function:
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
Subcellular Localization:
Cell inner membrane.
Sequence:
MTTHTTKKAPAQRKAKRSRGLFGHIWSLTWKLALIGLAVVTFYGIYLDQIIARKFEGQKWHLPAQVFSRSMALYPGAAVSHPQLMAELKLLGYRKVANPREVGEFSASSTKIELWRRPFLHPEGDQPEQRVMITFDSEGVSAIARMEDKRQLAVFHLEPVLLDRMITGDGEDRLFVSTEEMPKPIVQALLLVEDRSFYEHHGVNPFAILRAAFVNITAGRTVQGGSTLTQQLAKNFFLSSERSLLRKVREALMAVIIDFRYSKDEILEAYLNEVYMGQDKSRAVHGMGLASQFYFGRPIGELTTAQQAFLVAAIKGPSYYNPWRYPERSLERRDLVLRLLMESGELNTAQYKVAVESPLGLRNANKPVHQKLPSFYALVKQEVNQRYGDALLKQSGVKIYTTLDPMAQEAAEIAVTQTFKSLDKGNKSLQIGMVVTDKYTGGIAAMVGDKTPGFDGYNRAVEIRRPIGSLIKPFVYATALAPNSQFTLASPLKDQPITLKNEQGKTWSPQNFDKTFSGQVSLLTALKKSMNVPTVNLGIAVGVDAVVTTLAKSGWEEPLNEYPSMLLGAVNGSPLMVAQVYQTLADSGAYRKLTTVTAVLDSDNQPLPVTRSAKEQAITPDTDFLVQYAMQQVVRSGTATRLGNAFPGVALAGKTGTSNDSRDSWFAGFDERNVAAIWVGRDDNGKTSLYGSSGAMAVYQAFLKERPPIGLRSIPPSGVIKGYFDRDTGEAKEAGCSNTEALPALRGTYNPAKNCGEPLQWWQKILGQ
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
MTKTEKKSFHQSLAEWKLFIYNPTSGEFLGRTSKSWGLILLFYLVFYGFLAALFTFTMWVMLQTLNDEVPKYRDQIPSPGLMVFPKPPTALDYTYSMSDPHTYKKFVEDLKNFLKPYSVEEQKNLTDCPGGALFHQEGPDYSACQFPVSLLQECSGVNDSNFGYSKGQPCVLVKMNRIIELVPDGAPYITCITKEENIANIVTYPDDGLIDLKYFPYYGKKRHNGSRKEGWREEGPFCHQQGGDPRIHHQHSQTHPWSGLQEACSSGTQRNSEICHEGDGDSRCAHRHQAQ
The following text describes a protein:
Function:
Specifically hydrolyzes the glucosidic linkage in glucosylceramide. May prevent accumulation of aberrent glucosylceramide containing immature ceramide.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MSGIQFDVSRLCAATISIQGRHFVDSHGRVLHLRGANVSAASKVPATPAPKIHDHAQASYVGRPFRLEEADEHWARLKSWGLTFVRITVTWEALEHKERGVYDEDYLAYLRALLQSMEPYGLVAYIALHQDVWSRYCGGSGAPGWTLEAAGFDLSNEGENLSLSGAAFLDGIKSGRLAGERGLWPTGYQKLAAATMNTLFWGGETFAPLLKVPGQIDGKWVSRNIQVYLQEAFLAATAKLVKAVGDLETVMGFELMNEPHPGFIGIQSIHEWDYTTDLHLGQFPSPLQSFSMGAGHPTPNVPVYTRSFPFPTRVTSHVTANPEGACAWASKECPWEKHGVWRWSEAKQEAAALQQDYFVKNRDGGKVDFYEDFYFPFVRKWEQVIGENISSTKGLKARMVEAIPNELCPEWKEESRPKNMVYAPHWYDLNTLFKKKFGFMSVNVQGLARGMFILRALYFGTAAAKANYALQIKTIVLAARLKLGPVPVIFGECGVPMDINNEEAFRTGDWKWQERSMDALISAMEGALMGFNLWTYNPANRDDIGDDWNAENFSWYSESNRTKLLKNAEKSSDGLDVGARLLNVIVRPYPIATAGNPTSLAYDANACAFTYRFRSPLRVSAAAPTPEEYTEIFLPRRVFRKESTEWTVTAGGKVHVDWERERVFVWFEDSSLTAASIKDDTRPRRIDIWVIGRKVEENWSIAQILVAVVILLLGVLVAYYAQLYEWEKDKMIFQHLREANGM
The following text describes a protein:
Function:
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. pH-dependent Ca(2+) sensor required to activate the CatSper channel. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Associates with the CatSper complex via direct interaction with CATSPERZ, and senses intracellular Ca(2+). Together with CATSPERZ, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel.
Subcellular Localization:
Cytoplasm. Cell projection, cilium, flagellum. Note=Localizes to the principal piece of the sperm tail.
Sequence:
MKLTPGCFLWYLYMDKIYCLLSLRNVKALMVYFHLLDVHHRNTLNDVLFFHFLQHVTNLNKSQIGMIFDLLDWTAVGEIGFDQFYVLICILLAHQDHLEDHFMYRHSRPVFELLDLDGEMNIGAANFQNYRFLFNIKKQELRDLFHDFDITGDRLLNYKEFKLYTIFCTDKSIDRKKRRKDREAAREREKEKGKDKEKYLHLKKIYSSMLSHRSIL
The following text describes a protein:
Function:
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
METPAMFIKRCSRSIFLQVVIGLVIGVICGVGIPDLAVQMKPLGDGFIKLIKMLIALIVFCVVVNGISGAGDLKKVGRIGLKSVIYFEILTTIALVLGLVVAYSLGLGSGANIHLNELPAGDVALYTGRTQEIHGPVAFLMGLIPTSVFSAFAENDILQVLLFSVLFGSALNLVGEQASGVARLINEFSHIVFRIMGMIVRLAPLGVFGAVAFTTARYGVDSLSHLGALVLVFYATCLVFVMAVLGSVLRLSGVRMLPFLRYFREELLIVMGTASSDAVLPQVMRKLEHMGIRSSTVGLVIPTGYSFNLDGFSIYLTLAVVFIAHVTGTPLAMTDLITILLVSLVTSKGAHGIPGSALVILAATLTAVPAIPVAGLVLVLSVDWFMGIGRALTNLIGNCVATVTIARWENDIDMPRAQAILDGRLEAPAKADGEPLKRSAVAGEGKLHG