lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
GQPGLLGESGPSGPEGPQGGLGPRGPKGEMGHVGRKGPSGPKGDKGLPGPPGPPGPIGDVGLPGPSGAPGSGSLTAPKILTIYKGDKGDVGLPGEPGQPLINGIVEFVGYPKGDKGEQFGYPGEIGEKGIPGYPGGRLPGLPGLPGPEGEKGNPGPLVNGPEGFPGLPGPPGGPGPPGPPPGVPGQPGPRGPPGDRGFKGFGDPGDCDCEGGGSSGATGLPGPPGLNGSPGATGRKGEQGDTGSSGFSGPSGSDGRPGSRGFFGLKGEKGEPYLSRGSSSKGDRGAPGPRGPIGETGRPGRDGLPGFAGLPGSPGDPGFGTVGEKGFLGFPGIKGRPGAPGESGIGYIGLPGLRGEPGDPGFSGLPGPPGLPGPRLKGQPGRPGEPGRPGLDGSKGERGDPGFGNQPGSPPRGDPGIPGVPGLRIDGTRGRNGVPGLPGAKGQPGEILGAIPGLPGRDGEPGIRGDKGQPGSPGVPGGPLDGKNGIPGLRGERGIDGLPGVPGFPGPPLPGEKGDTGDPGFPGPAGMKGTPGFPGTPGTPGPRGPPGPPGPGTVDGLPGIPGVKERGFVGLTGFPGQSGRPGTPGFPGGKGLPGEPGRNGSPGRLGPQGNRDKGLPGLPGRQGRPGLPGLPEQSKGQPGQPGLPGLPGSPGLPGPKGEVGINGFPGMPGPRGDDGIPGAPGGPGEPGRPGGKPKGLSTFPGRKGADGPPGQPGFPGGPGARVPGPPGLDGLNGLAGSKGLPGTPITLGGRPGAPGIPGLKGERGDSYPGQRGFDGVKGQKGEPIPGQPGLPGESALAGIAGPVGDPGLPGLDGPPGPPGPPGSGTIQGERGEPGLPGFPGSPGRKGEPGFNGGPGYPGSAGVKLKGVPGDPGFYGIKGSKGTPPPGNIGLPGIPGSSSRSISIGYTLVKHSQSEQVPMCPQGMPSLWNGYSLLYVEGQEKAHNQDLQPGSCLPRFSTMPFLYCSPNEVCFFASRNDKSYWLSTSAPIPMMPVSAGQIQPYISHTAAGAEGGGQSLMSPGSCLEDFRATPFIECNGAKGTCHYFANKYSFWLTTVDPKREFVSSPNQETLKAGQERSRVSRCQVCSKLL
The following text describes a protein:
Function:
Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAQQQQQQHQQQQHHQQQQQLLLQQQQQLLQYNNNLYNLNYNMEDNERRKRREREKYERQQGIQSDDRETSLFGEPRRLNPSEGDAEITAALGEFIDARDHMNSSTVGIYRHASTNASSSRLPALSFGGSSLANSYSTSSASVNPAASLASSSASVPGQLPTSQQQQQQQQQQQHYQQQQRAPTYLKQADNKPPYNGRGGYPGQPMKNDIPSSSGMAPPRGPPRSSSSASQSNSNSNSINSSSATNNATSGATSASMSSPLGPPLSTQMPNGREKSFLGPPAPALPNGGRFVPPAASSKRPSNSVGLQPPPPEKDISKIITEMTNNYRVTPLTSIAATPHAPMSENYNLNGPNKFKYAFDSIGPLNSPPAAGASSLMTPLLAPIAPITSPIAPLLTTPPQASQLPLPLAPLAGATTVPPALGGMAAVAPIQQLMPTPPKASPTPPAIKPMKTEKNHSLEKQDSCLENDLELSESDDERKKEGRSAGNSSNSSESDSSESGSEASSKGDTQQQQQQQQQQQQQQLLLQQQQQQQLLLQQQQQRLAASANGSKKKYSQTIIASGANTISGLLTSSGLGGAGAGSVAGGAGGAGGAINATNNTCGGGGGSSGSCMGTMSSSSSSNKTPSPTDSNRWNLSRFFPKPANQTAAESVSPGVANAIGNVSMKVPGILPGGAQIIPESIDVTTAIVKNEKLHDEPRHVGDDEDDEADEQHRQQQQQQQQQQQQQQQQQRYGLSVTVKKEQLEQQQQQQLLLQQQQQLTTEQLALAGALPKNQIKRESRLSDSGSASSGSGSGSSSSDSAGGSSEVLQMPGPGETLQIPGVPAAITTVLRVPQAMQHKVQPNSVTLTPIGPLPASPKPRQKKPRKKKMSAATAPLDSSDEDEPTASSNKKHALELAATAAAAAAAVAVPVAAAAAPAIKKGRGRPRKQAQQQQQQQQQQLQQSGNLSSASASSSQAKGPTLTAAKKPLAKASVSNSNSTAPATVAAGTRKREHSSNSSSNSNTPTKKPTATFATMAAKLDRADALSSDDDSSSSSSCSSTKSSSSSGSDSETPAAAAAGAAASTATTVVTTSAQNPAKKRIVKINKVGVAGNSSSSSKAKRRYSVGSSSNSSSSSETEEQQQHKQQQLLLLQQQQQKQQLQHQQQLQQQQQQQQSLLGQFAAESLPQSAQRLSSSDCSSSSNSDSSSNSSGSSSSSDEDGEHRSGKRKSDKKKICTLTRIFNPKEGGAKKQGQVVIIDQSEEQQQQQQQQQQQAKELKPRATPTQLLGATLASPARTTTPHLTSLMCKIDLSKLARQHHHQPERLKAQQNGHLSSRSAEGARTPKDLQQICTPNGYVGGAAGGGAAASKLLGGVKHEHGVKPEPELEPGYEGKYKLNSVKQEFMLKQELPARRRKRSSSSSSSPYKEKKRKKEKAEQLSKELLPVPVLLPANNHERLSRDKLELLMQQQESAANGSPNKLQQQQQQSRLSQSQQQQQQQQQQQSLSQSTTAAATVAAAPIQLPTTCSEAVQTTPPPAAPQPEPRLIYRSHFDKEEENENDDLRKNDFLLQEAIRRKRAADSERDSFSQMTLYLEAIVYFLLTADAMERCNMEATWTMYKDTLSLIKYISSKNRPYQLSTNGNHESHNIVAILSLRCQSLISLKLYKLRRVNCRAIIASCTEFFRSGRGDILNGNTPSSISPSNSVGSQGSGSNTPPGKIVPQDIHNMLCKQNEYLTYVNSAHELWDQADRLVRNGNHIDFIRKLDHENGPLTLHSTMHEVFRYVQAGLKTLRDAVSYPQSQ
The following text describes a protein:
Function:
Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MIVFRYLIREVLKAQIAVLFVLLTIFISQHFVRILADASDGEFPASLIATLIGLNLPYLVVLVLPLSLFLGILMAHGRMYAENEMVILHGVGVSEWYVTRVTLILAVINMLFTGYLSLYVAPWAEEQQNQVLEKAQSEAGLAALVQGRFQASPNGRAVLFVERIGKDNELEKVFVAQLPDPNDEIGLTNVVVAKGGRVIEDQNGSQQLQLNDGVRYQGSPQQKDYQMIEFGGYKMQIKEQQVDERRRKLSALPLGELLKIDGPEAVAEFHWRLAIPLAIPIMTLIAVPLARVNVRQGKFAKMLPAVLLYLGYFGLMVAGRKALQDGVIPLYLGMWWIHLSALIMGILLLGKDRPLFTRLSAAMARKKVAA
The following text describes a protein:
Function:
Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.
Subcellular Localization:
Secreted.
Sequence:
MGWPWAPLTAFWALGIVGATALRIGAFNVQSFGDHKASDPDCGSVIAQILAGYDIALVQEVRDPDLSAVSLLMEQINSVSKHEYGFVSSKPLGRDQYKEMYLFVYRKDVVSVVSTYQYPDPEDAFSREPFVVKFSAPGCAAKELVLIPLHAAPNQAVAEIDALYDVYLDVIDKWNTDDMLFLGDFNADCKYVKAHDWPSIRLRSSQVFKWLIPDSADTTVGNSDCAYDRIVVSGAHMRKSVKPQSASVHNFQEEFDLDQTQALAISDHFPVEVTFKPH
The following text describes a protein:
Function:
Required for protein transport from the endoplasmic reticulum to the Golgi apparatus.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus.
Sequence:
MACIKSAQRAALTALAPDAPYLAAGTMTGAVDLSFSASANIEIFRLDFQSDSPDLPLLAAAPSPDRFNRLSWSRPGAVEGDSFSLGLLAGGLSDGSVAVWNPLSLISSEGKAEDAMVARLEKHTGPVCGLEFSELTPNRLASGAEQGELCIWDLKNPVEPIVYPPLKSVGSHAQAEISCLSWNPKFQHIVASTSSNGMTVVWDLRNQKPLTSFSDSNRRKCSVLQWNPDMSTQLIVASDDDSSPSLRVWDVRKTISPVREFVGHSKGVIAMSWCPYDSSFLLTCSKDNRTICWDTVSGEIISELPASANWNFDLHWYRKIPGVIAASSFDGKIGIYNLEFSGIYAAGDAVGAPARQRAPVPKWLKCSTGASFGFGGKLVSFHPVAPTQGAQASTSEVHVHNLVIEQSLVSRSAEFEDAILNGDKSSLRALCEKKSQESLSDEERETWGFLMIMFEDGDFVRTKLLAHLGFEPPQAPPASSPDELSQTLADTLNLDHATITDYADAQFLTDNGDDFFNNPQPSEASLAEDLVSTNGQQTEQEMSGDVVPSDPSIDKSIQHALVVGDYKGAVNQCLSANRIADALVIAHAGGSALWESTRNHYLKNSISPYLKVVSAMVGNDLMSFVSTWPLSSWKETLALLCTFAQKEEWHVLCDTLASRLLNIGDTLAATLCYICAGNIDKAVEIWSRTLKSEDGGKIYVDLLQDLMEKTITLALATGHKRFSSSLSKLVENYAELLASQGLLKTAMEYLKLLGSDEHSNELAILRDRIACSMEENDNARSYVSESTATPSLYGTNQSYTAPDHSQNVYQQVPQPYNVPSNTYSEAYPQQPTGAYGYNNTYQPQQPTHMFVPPSAPASSQQQPGPSPVPVPQQTVKAFTPANPAGLKNPGQYQQPNTLGSQLYTGTANQQYPSGPSASYPSGPPTTFHQPVSPVQYQPVAPPVSSFGPSAPVPATVPNQMFPHSAAANSTSRFMPSNNQSFAPRPGLSPAQPSSPTQVQAQPAPPAPPPTVQTADTTKVSAELRPVIGTLTRLFDETSKALGGSQATQAKKREIEDNSRKIGALFSKLNSDDISPNVASKLRQLCSAIDASDFATAMHLQVLLTTSDWDECNFWLAALKRMIKTRQNFRM
The following text describes a protein:
Function:
Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDIATEWTTNANEALTITLEPSKGKGKGKEVSNGSEKSHVFNPIFTYPIYGDVETILGYKNFELNLKMDASTMLPLVTVKFSDKLEFDGISFDDPVERLLEFLPEETATDEAEWEEKRVKELGDGFKPVGKEFGTFSVNSEKYTVHRSTLLDPETLKLHLRLQIFVPLFIEAGSYIDNEDDRWEIYIVYNAEKEIVGFSTVYCYWFYEPSAKESKAPKDASLEQLQKQPFSPTLRKRISQYVILPPFQGKGLGGQLYTLLFSRFYADPNVYEITVEDPSEAFDDLRDRCDLKWLADQGFPSEVFRMLQTTSAHGEKAGDNRTGRTKVVAGAFWTKWLEEHRLKYKLAHRQFARCFEMILLACLEVSSPTKKRNIKDARLFIKKRVYVRNREFLEELGGKIEVMSKLQETYESMEEDYARIMKPVLGYVKDGLKKRDRNDAGNEEAKRVKVE
The following text describes a protein:
Function:
Nonessential DNA polymerase. Required for DNA damage induced mutagenesis. Involved in DNA repair, mitochondrial DNA repair and translesion synthesis. Has a role in the bypass of abasic (AP) sites (By similarity).
Subcellular Localization:
Mitochondrion. Nucleus.
Domain:
The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.
Sequence:
MRFSIEYIDWELSPCDPAYDFVGKDLPTANEELTTVPVIRVFGLNEEAETVCCFIHNVFPYIYVEYSSFAETLDLEVPDFLSQLQTSINYALALAARANPETYKPAVQSVQLVKGIPFYGYSFCFQKFLKICLFSPKNRDRLVDLFRQGAILNKVIQVYESHLPYLLQFMVDHNLYGCAPIDLDDSIIKRDDLLSFCNVEVHVSPNAILNACWLSERNIHTDLYETHASSPNSLLVTSLAEIWKSEASRRNLTSSDETNSFSKLHQSQFGLKEESSHEPRSSQHWKNEVAMKDLLKNLIKSKLESSSDVNTPLIFDPWPELPTIYSAIHTKDYVRPSQNDISVSQISVDEKICTSYESLPKIQLEQNTAPVIESSFEQLDSELERILGDTLFDSFPYVEPNVDRSKFPKSPLNSSQEVTIHSSQDRQSPPSSPLKDVPSQINPFSPSLRLKGGSPITKREIEFCRDLPNRPTSSEPNQGDTRKAGKRLKYSRNLDDYHICTQIPEDYSPKFLSQHESFVYKQQPPSTDDLYGTMKKLKIPFSIPTNVHYSSEKDIPSYSQEYLGKSHYPIGVSSRYLPEFQSDGSVSEKVRLNPLKLSNFHGERTWQYIKPAPLAVDLSNLESKEAVSEEIQSPQRLSRSKVFRKDPYSCVRILALELFCCSHGGLTPDPTKDSIECCFWAYQEDVNSSMIDRVGFIVVDKSASNSSFGRSFPSCTVLVVNSELELINEVIGLNRQLDPTIVCGYEVHNSSWGYLIERASYRFNYDLPEQLSRLKCTSKANFAKKENAWKYTTTSSINIVGRHVLNIWRILRGEVNLLNYSLENVVLNIFKKQTPYYNQADKVHLWQSSRFHEKQILLNYMLNRTRYCLEILSACAIVTKIREQARIIGIDFMSVISRGSQFKVESIMFRIAKPENYIFPSPSAKQVAEQNALEALPLVMEPKSDLYNNPVVVLDFQSLYPSIIIAYNLCYSTCLGPVKIVNGKVKLGFMFHSSNPNIVNLIKNDVYISPNGYAYVKENVRKSLLAKMLEELIETRNMVKRGMKDCDSDYVNKVLNSRQLALKLIANVTYGYTSASFSGRMPCSEIADTIVETGREILSYSLEYINTLDFCHAKVVYGDTDSLFVELPGATKEQAFDIGQQLANNITSRFPSPIRLKFEKIYFPCFLLAKKRYVGFKFESVSQKAPIFEAKGIETVRRDGTPVQQQLLRRCLEILFKTKDLSTVKKEFQNVCYQIMSGNVPVMDFCFSKEVRLEKYKELSTAPPGAVMARRLMTKDPRREPQYGERVPYLIIAAAPGTTLANRSVAPEEFLSSSFSQLDINYYINNSLIPPLDRFLNLLGASAQSWYHEMPKPRTSLKLTETVKGGIQKKTLDTFLMEKLCSSCLKNNIEIIPDKINSLCSDCLKNPCATISKAVTQHNAYNKKLSLLFDICRGCSKLSSSDPVLCKSNSCKVYYDRAKTENYAKVQAEMLTKTLGSLDW
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MVAEKKRMEGPQESRGISKQKWLDERKKKIKKLLDANRLDMKEAYMLDTQQMAETKYKKRKKEPAPAGWEVFNQKTLYDAHKKRTKKIEVDLDEYNRMKEAVPEFYREASSLEYGKAPKVSEDKIERMVKELRDKDEKRKAFSRRRRFHEEKDIDSINDRNEHFNRKIERAFGKYTLEIKNNLERNCFA
The following text describes a protein:
Function:
Multidrug efflux pump.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSIKNTFMRYILTNVIGMIGLSCYILADTFFVSKGLGVTGLTSLNLSISIYSFINATGLLIGIGGATKYSIYQARDKHNKANIIFTNSIKIGVICGIIFLLIGLLGSSSLSNLLGADKDTFAMTNTYLRTLLCFAPFFILNNIFIAFIRNDGDPKLSMAGMLIGSLANIILDYVFIFPLQWGMFGAAFATGLAPIISISILTRHCIKKKNCFHFYKSKLSIKQVTYICSLGLSSFITEIASGIILIVFNLLILNIAGNIGVAAYGIVANLALVATSIFTGVAQGTQPLLSENFGQGNNKKILQLFKYAIYTSLAISVVLYFIVVIFNNQLVEMFNRDHIEILSKTASNGLIIYFAGFFFAGINIITSAVLSSINEPKHAFTISILRSGCIIVPVALFLSYFFKMTGIWLSFPLSEIVILILGVFLAKKSLKRL
The following text describes a protein:
Function:
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
Sequence:
MSMPLGVSVNSHQSASQVEHIADRFSAAAKHYQEHNCLQRLSGASLLQGFVAKGAILDIGAGPGTDFANRAMGEEMRVYALDIALGMLQQLKTIYPEHQCVCGNAEQLPFVDRSIDCIYSNLALQWCHDFSAATSEMARVLKSGGEAHLSIVAAGSLAQLSNLGLRVNGFLSLESLQAAFDDTDWQFLDVKLMPMTVYFQDLKALLYSIKGVGASVQSSVQTVTSSESDAHFGKLRGRHDWQALQQRAEQFREAQGLPLTYQIAQFRVRRQGGSV
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MARKKKRSWKVPKILWRIFNEKARSLATTITCIIPPPPSQPFPIPCRCEGRSCLQCCEDPISFLLRPDDPLDYKKLLHDCFVVVNDDAPFLEFNPGRHWSQKQIVGRVIEMMLFQRPKPCNLVCTGYNKLTRSSMIVELLTSSAWDILLERVGDECMVYLLWHASIFLPLSHKKHLQVAGSPINKLCKKSSNNERKPKSGIQELNILCVFVHIDRAGKKRKGTDNSISVSKRQQCSSFSGYDIYCAGSRIQEAAAKSSNGELQRSSSQTAEKHKKFYRPFDWKRQKRHRQLNIPECRHEIISRTIFSDESCLPGNLKSPSNISQMPVQCSCYLMLKAPHLFSHWNEINRQSMFYNLECSSSVLPQELPNFSSSKRLMENIFCLSDANIRYSRVVMFYEFCGIVNGGSDLAVASLGYHSFLKLLKMLIRRSRRCKSLKLLEKYCPLSFFNQKAVGKSSTIVESNILDKRVLKESHGVGAKEYNKILEADNVQLESTKPYCLQSQVGAFIWAVCRSIVPPDLLGTPFNWRILRRNIFKFIRLRRFEKFSMKQCMHQLKRSDFPFLLNNHTSCCLNGQVPKNGTGQKKFSEASFSIHDIKHKLFVNWIFWFFSSLVVSLVQANFYVTESEHGKQDVFYYRKPVWEKLTDHAITCLKDRSYLELDEAAVRAIIDKRPFGFSRLRLCPKQNGVRMLANLKASSRMLEGKSCSKHKCSWMHRSLKACSRKVKSKRFKSVNSVLRGTHAVLKGLLLKEPEKLGSSVFDYNDVYRKLCPFLTTLKNVSTTVPGLFVVVADVSKAFDSIDQDKLLSIMEDVITKDEYHLQQIRQVGCSSRCLWDYENLMLVDGTVNKGSNLISSVPVRSLSSVLVDQGCSRILKKEELFSNLYEHVKRNVLQLDKKFYLQGMGIPQGSVLSSLLCSLYYGYMEKHEIFPYLEKTFEPAAEDLSTRHVFSDASDAQNSSEDAVIFPPTYLLLRFIDDFLFISTSKEQASGFLSMLRRGFPDYNCYMNEEKFCLNFDIEHQAGLLSNRIYVVDDGSSFLRWSGLLINCCSLEIQGDYTRYLDNHLSSTLTIRWQGKPGNYLKKKLCGFMRPRCHPLFFDLNINSASVVRLNIYQAFLLSAMKFHRYVSEISEIFKPFGRYCLKIIERSFRYMQRLIGKRMGSIRLGSGLSPVLKLMKEEVVWLGLNAYIEVLKRKQSRHRVLLSMLRCKYFAHRITGNESSELRYAVERSHSSSLWKIKY
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MDKEFALRIPYGVPKRVRFTLFSENEKNSLIPIVPRESSSDQMSMFSELNSTRLGVIFQEENECPTCSGKAGDQDPSVLCPGHLGVVKFGYDIFHPMIIDDLATLMNCFCPNCYHLKFFRLFKETDRELAINALNRLRDTTPTLNFLPKLAELSATIACCERNILYRKKASGTSRNGVAPQPLILAVSKSTRGSTARQAKDQDQLMDAHTCKLLITRYNKDDIVLLGLKRDHIENFIISSIQVGSRAVRPSIRTDGTTAEDQLTEMYVSLFRNIRDCNNNSLNAGGGATGAKSQIGPNDIYNAYKTLISAKGLNADGGSVPTKGIFERLSGKYGRMRSNLMGKRVNYCSRSVITGDPTISINELGVPRSVASRLTFPEVVTARNRDFLMKLVSNGNRYPGAVSKTLPSGTVQLIDTQVINSTGWGSSTDADGRLGGETTNDPLPLGTIVNRHLLDGDYVLFNRQPTLHKSSFMGHRVKVLPYSTYRLNLSATSSYNADFDGDEMNLHALQSLEAVAEISELCMVSNQVVSVKDNRPIVYIVQDVLLGCYLFTGKDVTIPFARVCEYIMWMGFSRTSDPTYAHKLQRYDKGSVNQRGHSSASMSYDFSDHTSGSYNPAEYDSSSYLVGNSATGSVVDGRGSYLSTGNYGASSASRKAYEDNINNDNGAYFKRPGSNVNTNDHVLLNVSQPAICYPEARWTGKQVFSMFVPRGVFYRSGDPKDISAHADKYISFLDGSVMCGRIASSVVGGTESALIHILFRDYGIEPCRAFIDNCQRVVCRFMLDHGFSVGMGDMVSSEHTERKVAEIQTKLSKDISELFKLSIHYKIKLAPGQSRNDAFEQEVISKVSGTSLALEKVITDAAPHRNALLVMINAGSKGKKFNMMQISSSLGQQFLQSKRMPHRFETHRSLPCYSPFSSLNMESRGYIFNSFIRGLNPAEFYFHAVGGREGVCDTAVKTADSGYVERKLLKVMESVCYRYDNSVRNDSNEIISFRYGDDGIDPHKSESREFKDFSISDMDFLRAHYIDWSQIVDFQNTEMDESTDFYATLVREKFAVIIAKLRDTPEQFAHLCDGVSFYEVCDDELRAKGFDNLVLDNNLVSFTELSSYLQNHYALFMDAESSPGYVPENIDDSWLDIGVKSSLVLERDFAISTILVEYIVLLLERIWLQRSRITLDTDVKKFTFGMNLDRIIQSEIQAGSINKVSRLIRESAWRCYLKPFEAIEKVNKLLSRIKSFRPKESTLFRVILRQCLSSKSCCYKYRLTSEQLDRILATIEEKFVRGQVSPGEPVGPLAGHSVSEPATQLTLNTFHTAGTSALGGLGLPRLKELIDFRNPKISVSTIYLNISNQDPANAGVDTRCTSHSPMLFNRPVAPRPNSYNIASAEEATGRNIRQSKAWMNLAAKIEHTTFNYYIDDYKLIFDPFDELTCVADDREWLHLESEIGHLQQQVYGERPNEAVRFYSPFVLRYEIGLKQMQQKIEAGITIQTLVSRLILMLQQIYTSRAGRPKSEDDDEDDEDDINIKQKAMIGREMPIINYYTGLGKTVIRVRPSLTEDEYNAVKGSAIGSGAPDMEKSRLLAERYDGVDAFLRNVHISGNESIRKVFMASSNPLVHYGYDGFTSNVDVFSQGSSDGLSMHKMSEGDLSKIGSIGKFTQPNSDISELYLQTDGSDLLWILTQPEVDFTRTWTTNVREIYEILGIEAARALFIKQIRATLDKVDLNIHHYLILADIMSSRPQNNKMISINRYGMQATNTGVLAQATFERPGATVLKAAAFGVVDPLKSVSSCVVMGKQGDFGTGCFDLLLNCAELPSINEDELFPNSYYLKVHNATTEVRPTAGAEETPVDSMGMPFSTTFISPTATAMVTPTSTYTSHSSVRSVVSAGGRVDANMNPLFSPGCNRSRQAENASRIFSSYTANTLTSAKSSLPTQLTITSRSRGLSNIVDGRDSRIASITSAVNSKMSAFSMTSCNSINSFRSALASKASTHSNQYDTSDLVDVKGAGRYGIFTHSTNMSYENTAASIRNSGGMFASRSGSASSVRSQSATNIDASAADSGQSGELRDNHEDDNNDYAEW
The following text describes a protein:
Function:
Pleiotropic ABC efflux transporter that confers resistance to azoles such as itraconazole and voriconazole.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQNTTVHGLYFCHPTSIDGNPELLAVSRRSLSRGDHVTFTASQCRPKRLQCCQWHSCTISSTHIPTKDDLGKSFAYLRLLFSLDYTIADVLLIIGGLLFAICAGIPFPLLGIVFGDLINDLNTVTCSSSDRATADLSSAVRAKVLYVIYITIANFCFIYAHSTCWCLVSERLARRYRRRYFESIIKQEAKFIESLPSGDVVSRLVSDIELVQSGTSEKVGLVISTLSYFVAAYVVAFIKVPKIAGMLVSVVPCFFLMALGGGHYIKKFAGRLAEKVNAATSIASSSLSHLTLVHAFNANDRLEKRFAGYLLQSRKDAVRKATTHAAQLGCLYFIAYSANALAFWEGSQMISKSVADGNSGTSVGAVYTVIFVLIDASFILSQVAPFIHVFASAAGASERLLQVINRPSAIDGTSDSGDKTAAFGEEDIRFRDVHFKYPSRPDVPVLQGVTFNIPPKKHTAIVGPSGGGKSTVVALLERFYDPDSGDVLIGDKNFRDINVRYLRGNIGYVQQEPSLLDRTILENIAYGLVCVTEIVDLVKEAAANANALGFIEALPYGFATNVGTAGNQLSGGQKQRIALARALVREPCLLILDEATAALDSTSEQLIQAALNRVSERVTTVSIAHRLATAKNAHKIVVVQSGRVTEEGSHTDLVSRGGVYAEMVRLQNLGKLSLDDRVISGDMISALNATPETRQLLDEKQAFVDGNRSDITEDTVVADTPSDSRDGSEEEARKKRKRTRSAGFVTRYTFALIRPNLHWVLLGLAMSVIIGGSYSAEAIVFGHTVGSLSPCRSAEAISRDGNLYGLLFFILALVEFGANVVGGCAFGWAADKVLYRIRVLSLRSLLGQTVKWHESEDRTPGTLLTYITGDASALGGITGTTIGLLLATAVNLIGGLVISFSIAWKITIVLFPTIPVLLVSGMMKLRVQKQLAERHQKAFAKATAVTIEAVDNIRAVSAFSLEKQSYQVYGRALRGPYRATIKATFHGNAWLALAFSISNLVYALAYWWGSKQIAEGRYSQTQFFIVMPALLFSTQSCGQMFALAPDISKAGVASSNIVELLTTRSAEDEVTPGSSHSFQPSSSMGAQLRDVHFTYPHRPERPVLKGLNIDIKPGQFCALVGPSGSGKSTTFAMLERFYRPNAGAVVIDGVDVTRQVGTEFRDDIALVPQQNILFEGTVAFNVALGACPGHEPTQEEIEEACRMANIHDVIMTLPQGYQTMCSHDGKQFSGGQRQRLSIARALVRKPRLLLLDESTSALDVESEKRIQEALATLAGRTTVVAIAHRLNTIHRADQIFLIEDGRCIEQGTHQQLIQRSETYRTSVIHQSLET
The following text describes a protein:
Function:
Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Recruitment to microtubule is inhibited by microtubules polyglutamylation.
Sequence:
MADLSLVDALTEPPPEIEGEIKRDFMAALEAEPYDDIVGETVEKTEFIPLLDGDEKTGNSESKKKPCLDTSQVEGIPSSKPTLLANGDHGMEGNNTAGSPTDFLEERVDYPDYQSSQNWPEDASFCFQPQQVLDTDQAEPFNEHRDDGLADLLFVSSGPTNASAFTERDNPSEDSYGMLPCDSFASTAVVSQEWSVGAPNSPCSESCVSPEVTIETLQPATELSKAAEVESVKEQLPAKALETMAEQTTDVVHSPSTDTTPGPDTEAALAKDIEEITKPDVILANVTQPSTESDMFLAQDMELLTGTEAAHANNIILPTEPDESSTKDVAPPMEEEIVPGNDTTSPKETETTLPIKMDLAPPEDVLLTKETELAPAKGMVSLSEIEEALAKNDESSAEIPVAQETVVSETEVVLATEVVLPSDPITTLTKDVTLPLEAERPLVTDMTPSLETEMTLGKETAPPTETNLGMAKDMSPLPESEVTLGKDVVILPETKVAEFNNVTPLSEEEVTSVKDMSPSAETEAPLAKNADLHSGTELIVDNSMAPASDLALPLETKVATVPIKDKGTVQTEEKPREDSQLASMQHKGQSTVPPCTASPEPVKAAEQMSTLPIDAPSPLENLEQKETPGSQPSEPCSGVSRQEEAKAAVGVTGNDITTPPNKEPPPSPEKKAKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTSGGLNKKPMSLASGSVPAAPHKRPAAATATARPSTLPARDVKPKPITEAKVAEKRTSPSKPSSAPALKPGPKTTPTVSKATSPSTLVSTGPSSRSPATTLPKRPTSIKTEGKPADVKRMTAKSASADLSRSKTTSASSVKRNTTPTGAAPPAGMTSTRVKPMSAPSRSSGALSVDKKPTSTKPSSSAPRVSRLATTVSAPDLKSVRSKVGSTENIKHQPGGGRAKVEKKTEAATTAGKPEPNAVTKAAGSIASAQKPPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEALPCPGPPAGEEPVIPEAAPDAGAPTSASGLSGHTTLSGGGDQREPQTLDSQIQETSI
The following text describes a protein:
Function:
Involved in phosphonate degradation.
Sequence:
MMNSPIQAVIFDWAGTIVDFGSFAPTSIFVEAFKQGFDFEISLAEAREPMGLGKWQHIEAVGKLPTVAQRWQKQFGRPMQASDIDAIYAAFMPLQIAKVADHAAPIPHSLEVVEQIRSRGIKIGSCSGYPRQVMDVLIAAAADYGYRPDYVVATDDLAQGGRPAPFMALKNVIELGVTDVRACVKVDDALPGIEEGHNAGMWTVGLLLSGNEAGLTLEEYQHADDQTLQAARERAQAKLQQAKPHYLIDTVADLPAVLAQIEQRLLAGERP
The following text describes a protein:
Function:
Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes at the spindle midzone, midbody and basal bodies of primary and motile cilia.
Sequence:
MDQSGVLLWVKAEPFIVGALQEPPPSKLSLHYLKKVAAYVRTRATERAYPRLYWPTWRHIACGKLQLAKDLAWLYFEIFDNLSERTPEERLEWSEILSNCTTKDEVEKQRNQLSVDTLQFLLFLYIQQLNKISLRTSFIGEEWPSPRNRPKSPSPAERSSCHNKNWNDYNHQAFVCDHLSELLELLLDPEQLTESFHSTQSSLLSREAVTALSFLIEGTVSRTKKVYPLHELALWQPLHAANGFSKISKTFSLYKLEAWLRACLTTNPFGLSACLQSGKKLAWAHKVEGATKRAKIACNAHMAPRSHRIVVMSQVCNQTLAKSSETLVGAHVRAHRCNESFIYLLSPLRSMTIEKCRNSTFVLGPVETALHLHGCENLKVIAVCHRLSVSSTIGCTFHIMTPSRPLILSGNQTVTFAPFHTHYPMLEDHMARTGLATVPNYWDDPMVLGGEGTDTRVFQLLPPSEFYVFVTPFEMEGDTAEIPGGLPPAYQKALAHREQRIHNWQKTVKEARLTKEQRKQFQVLVENKFYEWLVSTGHRQQLDSLVPPPAASNQVAKKDLTWSHGALET
The following text describes a protein:
Function:
Plays a role in posterior cephalic patterning. Probable subunit of a heterodimeric regulatory protein involved in the control of head morphogenesis. Isoform B may have a repressive effect on Dfd response elements, thereby modifying the activity and specificity of the Hox system and moving the body anterior/posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MISNKKSYAMKMLQLALALSLLHYNPDYLLHRWDSQLELGTHGDGWELEMLRTVHRLDMDHNPYGNRKGLSPRIEDLLNFDDPSLGGMANGIGGCKLPPRFNGSTFVMNLHNTTGNSSVQTAALQDVQSTSAAATGGTMVVGTGGAPTSGGQTSGSALGEIHIDTASLDPGNANHSPLHPTSELDTFLTPHALQDQRSIWEQNLADLYDYNDLSLQTSPYANLPLKDGQPQPSNSSHLDLSLAALLHGFTGGSGAPLSTAALNDSTPHPRNLGSVTNNSAGRSDDGEESLYLGRLFGEDEDEDYEGELIGGVANACEVEGLTTDEPFGSNCFANEVEIGDDEEESEIAEVLYKQDVDLGFSLDQEAIINASYASGNSAATNVKSKPEDETKSSDPSISESSGFKDTDVNAENEASAASVDDIEKLKALEELQQDKDKNNENQLEDITNEWNGIPFTIDNETGEYIRLPLDELLNDVLKLSEFPLQDDLSNDPVASTSQAAAAFNENQAQRIVSETGEDLLSGEGISSKQNRNEAKNKDNDPEKADGDSFSVSDFEELQNSVGSPLFDLDEDAKKELDEMLQSAVPSYHHPHPHHGHPHAHPHSHHHASMHHAHAHHAAAAAAAHQRAVQQANYGGGVGVGVGVGVGVGSGTGSAFQRQPAAGGFHHGHHQGRMPRLNRSVSMERLQDFATYFSPIPSMVGGVSDMSPYPHHYPGYSYQASPSNGAPGTPGQHGQYGSGANATLQPPPPPPPPHHAAMLHHPNAALGDICPTGQPHYGHNLGSAVTSSMHLTNSSHEADGAAAAAAAYKVEHDLMYYGNTSSDINQTDGFINSIFTDEDLHLMDMNESFCRMVDNSTSNNSSVLGLPSSGHVSNGSGSSAQLGAGNPHGNQANGASGGVGSMSGSAVGAGATGMTADLLASGGAGAQGGADRLDASSDSAVSSMGSERVPSLSDGEWGEGSDSAQDYHQGKYGGPYDFSYNNNSRLSTATRQPPVAQKKHQLYGKRDPHKQTPSALPPTAPPAAATAVQSQSIKYEYDAGYASSGMASGGISEPGAMGPALSKDYHHHQPYGMGASGSAFSGDYTVRPSPRTSQDLVQLNHTYSLPQGSGSLPRPQARDKKPLVATKTASKGASAGNSSSVGGNSSNLEEEHLTRDEKRARSLNIPISVPDIINLPMDEFNERLSKYDLSENQLSLIRDIRRRGKNKVAAQNCRKRKLDQILTLEDEVNAVVKRKTQLNQDRDHLESERKRISNKFAMLHRHVFQYLRDPEGNPCSPADYSLQQAADGSVYLLPREKSEGNNTATAASNAVSSASGGSLNGHVPTQAPMHSHQSHGMQAQHVVGGMSQQQQQQSRLPPHLQQQHHLQSQQQQPGGQQQQQHRKE
The following text describes a protein:
Function:
Transcription activator required for resistance to arsenic compounds and for a regulated expression of ACR2, ACR3 and YCF1.
Miscellaneous:
MISCELLANEOUS: One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly localized in the cytoplasm under non-stress conditions and redistributed into the nucleus after HOG1 phosphorylation in the presence of arsenic. The major karyopherinse CRM1 mediates nuclear export which is also regulated by arsenic stress.
Sequence:
MAKPRGRKGGRKPSLTPPKNKRAAQLRASQNAFRKRKLERLEELEKKEAQLTVTNDQIHILKKENELLHFMLRSLLTERNMPSDERNISKACCEEKPPTCNTLDGSVVLSSTYNSLEIQQCYVFFKQLLSVCVGKNCTVPSPLNSFDRSFYPIGCTNLSNDIPGYSFLNDAMSEIHTFGDFNGELDSTFLEFSGTEIKEPNNFITENTNAIETAAASMVIRQGFHPRQYYTVDAFGGDVLLSAMDIWSFMKVHPKVNTFDLEILGTELKKSATCSNFDILISLKHFIKVFSSKL