lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Sequence:
MKSLFLSEKIYVLILAGGTGSRMGSKIPKQFLELNGEPILIHSLKRFQNWGKQKRIVLVSHFESIPKIESICASYLENEDRIVQGGENRHSSMLCGLSVLDFKDEDIILVHDAARPFVLADELDSLCEKVRSDGIATLASRTSETVLEELNGKTVSFLDREHVWFMKTPQGIRGDVLKELLTFSVDSIPTDLCSWALTFGKTSSIVESNPLNLKITRKEDLDLAEVFSSLFQKISSDI
The following text describes a protein:
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. Targets also the receptor for advanced glycation end products RAGE for ubiquitination and subsequent lysosomal degradation. Directly controls HGAL/GCSAM ubiquitination and degradation and thereby decreases BCR signaling.
Subcellular Localization:
Cytoplasm.
Sequence:
MEAGGLPLELWRMILAYLPLPDLGRCSLVCRAWYELILSLDRTRWRQLYLGCIECRHPNWPNQPDVEPASWREAFKQHYLASKTWTKNAPILETSVCFSLFRRRRTRRTLSVGPGHEFHSLGSALAMSSLFDRILLFPGLHEEQGEIILKVPVEIVGHGKLGEVALLASIDQQCSTTRLCNLVFMPAWFSPFMFKTTSGHVQFDNCNFENGHIQVHGPGTCQVKFCTFKNTHVFLHNVPLCVLENCEFVGSENNSVTVEGHPSSEKNWAYTYLLGLIKSSPSVLPAEDSDSVMALDLESRDQAWSPRTCGMVIEGSQSPTSPASSPPKAGAREAEVGSDGERVARTPDSSDGGLSPSSEDEDEDQLTYRLSYQVQGPRPVLGGSFLGPPLPGASIQLPSCLVLNSLQQELQRDREAMALASSVQGCLIRKCLFQDGKGGVFVCSYGRAKMEGNIFRNLTYAVRCIHNSKVVMLRNHIHHCRASGIFLRLEGGGLIAGNNIDHNSEAGIDIRKKSNPLILCNQIHHGLRSGIVVLGNGKGIIRNNQIFSNKEAGIYILYHGNPIVSRNHIFRGHAAGIAVNENGRGLITENVIRENQWGGVDIRRGGVPALRSNLICFGYSDGVVVGDEGKGLIEGNTIYANKGCGVWMMSSSLPHVTSNHVSYNGLYGLAVFSQKDGSGEFPGGHGAQENFSEDGDAILWEPEPEKDDDPLRRPVTVALIESNSVNHNGASGLYVQSSEALHVITNVIHANGDRGITVAQSSQLTRMANNSISCNRQSGVKVEAQCKVELRGNGIYDNRGHGIITKGDSTVVIENDIIGNRGSGLQLLPTSDTKVIKNRIHSFRAYGIAVQGHAKALVQENIIFQGKSNKTIFQQIPSNQECIVQNNKFLVFKKKSDTWRLVNPPARPHLENSLRGPSAAHSGQKVTAMATRITAHVEGGYHSKRSIFCTIL
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 6300 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MLAQTFKKPHRAVLEQVSGTTVFIRNKRTKSKSSLSPLAQRVVTQLSVMSASRKQPKLLKLAREDLIKHQTIEKCWSIYQQQQRERRNLQLELQYKSIERSMNLLQELSPRLFEAANASEKGKRFPMEMKVPTDFPPNTLWHYNFRK
The following text describes a protein:
Function:
Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart. Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes. Thereby contributes to oocyte survival and the resumption and completion of meiosis.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Core component of cytoplasmic lattices in oocytes. In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions. Expression largely disappears in blastocysts.
Domain:
Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA.
Sequence:
MVDNAGDYEARGDRLLGFPLPSPRVRIRPWWFPAQELRNPLVFFLEAWLADLIFGPDRALVPEMEWMSQALLMVDAVDAGNLVEVTVFARPAVQRQVKSVLLSQASVHREQRARAEKMEQLEEFLKAQAPGPQVPQHPVA
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of plastid-encoded RNA polymerase (PEP) to specific initiation sites and are then released.
Subcellular Localization:
Plastid, chloroplast. Note=Seems attached to membranes.
Sequence:
MASFNSFPIPKQIVGSSSSSSSSTSRPRILVRSSLTSSMTSTNSMLVFVHPHPLIKHWLSLLRSDQTSFPIFVRIPMTSVVATRWSFLSSVKEESRIYQNDSLKACGCASVSPYTAQNNVYVELKDPKENIGVGSAERSYSSRSMLQYNLLAKNLLALEETFVALDSVRMERDIMLQMGKLGAAELFKTCLSRYRGSSITSCLSDTTELVDTTPNQQVFVSSRRKVKKKARRSSVTAENGDQSSLPIGLRTTWNNIDVPRVRRPPKYRKKRERISRNETEMSTGVKIVADMERIRTQLEEESGKVASLSCWAAAAGMNEKLLMRNLHYGWYCRDELVKSTRSLVLFLARNYRGLGIAHEDLIQAGYVGVLQGAERFDHTRGYKFSTYVQYWIRKSMSTMVSRHARGVHIPSSIIRTINHIQKARKTLKTSHGIKYAADEEIAKLTGHSVKKIRAANQCLKVVGSIDKKVGDCFTTKFLEFTPDTTMESPEEAVMRQSARRDIHDLLEGLEPREKQVMVLRYGLQDYRPKSLEEIGKLLKVSKEWIRKIERRAMAKLRDQPNAEDLRYYLNQ
The following text describes a protein:
Function:
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
Sequence:
MIEVMVQLKNVSKKFLENKSLAVDKVSLDINKGEFLTILGPSGCGKTTTLRMIAGFEDQSDGQIFINGEEVSKVPAYKRCVNTVFQSYALFPHMNIFENVAFGLKVKNVPESKIKEKVTEMLKMVQLEGYGNRMPSELSGGQKQRVAIARAVINNPKVLLLDEPLGALDLKLRKQMQLELKQLQRKLGITFIYVTHDQEEALTMSDRIVVMNEGVIEHVGTPADIYERPKTKFVANFIGETNLFEGKILEKDDNKYLLDEDDGEEILITGSPTSMTQEVCLAIRPERIKLSNNVDNGMVGIKVSVKERIYNGSVIKTVVVTQNGREFVVSEPISDVYSLDTHNKNYVFATWNPKHAVVMH
The following text describes a protein:
Function:
Involved in cyanogenesis, the release of HCN from injured tissues. Catalyzes the stereospecific addition of HCN to a variety of aldehydes in vitro. Has no oxidase activity. The redox properties of the FAD cofactor appear to be unimportant for catalysis.
Sequence:
MEKSTMSAILLVLYIFVLHLQYSEVHSLATTSDHDFSYLSFAYDATDLELEGSYDYVIVGGGTSGCPLAATLSEKYKVLVLERGSLPTAYPNVLTADGFVYNLQQEDDGKTPVERFVSEDGIDNVRGRVLGGTSIINAGVYARANTSIYSASGVDWDMDLVNQTYEWVEDTIVYKPNSQSWQSVTKTAFLEAGVHPNHGFSLDHEEGTRITGSTFDNKGTRHAADELLNKGNSNNLRVGVHASVEKIIFSNAPGLTATGVIYRDSNGTPHQAFVRSKGEVIVSAGTIGTPQLLLLSGVGPESYLSSLNIPVVLSHPYVGQFLHDNPRNFINILPPNPIEPTIVTVLGISNDFYQCSFSSLPFTTPPFGFFPSASYPLPNSTFAHFASKVAGPLSYGSLTLKSSSNVRVSPNVKFNYYSNLTDLSHCVSGMKKIGELLSTDALKPYKVEDLPGVEGFNILGIPLPKDQTDDAAFETFCRESVASYWHYHGGCLVGKVLDGDFRVTGINALRVVDGSTFPYTPASHPQGFYLMLGRYVGIKILQERSASDLKILDSLKSAASLVL
The following text describes a protein:
Function:
Hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels. Acts through binding to its receptor, GPR146.
Subcellular Localization:
Secreted. Note=Secreted via exosomes, secretion is induced by feeding and cholesterol absorption.
Sequence:
MAKQKRKVPEVTEKKNKKLKKASAEGPLLGPEAAPSGEGAGSKGEAVLRPGLDAEPELSPEEQRVLERKLKKERKKEERQRLREAGLVAQHPPARRSGAELALDYLCRWAQKHKNWRFQKTRQTWLLLHMYDSDKVPDEHFSTLLAYLEGLQGRARELTVQKAEALMRELDEEGSDPPLPGRAQRIRQVLQLLS
The following text describes a protein:
Function:
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular Localization:
Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton.
Sequence:
MDSDDNDKTSDENIRSSLGDEVTGLRAKRLIATLVCLFVLFMITLITLALNIWIISTLRMSSNGIPFLRFYHSFNEKTKDMEKTIEMSGNKIRFDKVVSNKIMGFPEKDITITAPRMLMTSRQNDSLLVMSEKLCKLERVNNFQVLSPKDGRTLFSARHPTVTIDKRIKKLAAERIITNKIRSAVDETLKVNGENVVLRGNEQVRIDARNVNFEGMKRMVFNISRDGILHMRGRVRLGTERLLFQCPHLRPYLPVWMECVFVLVLNSTTNCLSFQPISTVLPVTHFVHEIL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MDADDAARSRRRMDLNLYLGLPRAPRPRRPDLGSDLALGNSMLSSSPSSSAASADAPPPDPEPLHPPYSPTRADLMRPPPEPYHLSASVVRAPYLEAEEVPITELAEEFGFSHPPPPPPPPRPSELLGWVDRPSSSTASSTFRPERSERYRRAISLNGRQLRCLRPRRFRSDLPPLSSEAPGPDNEPALEPPPQQPVQDAVEDNKVIDDGAMVGADDEPADRGKNTAMFECNICFDMADDPVVTSCGHLFCWPCLYQWLHVHSTHKECPVCKGEVTEGNITPIYGRGNSTSDVEKKVADDGNVSSPNIPARPHGNRLESFRQQFHHLRPISRRLGEAHGILSSWRRILDQQIMTSASRFEAPPESSLQEMMDHAHQTGRLGRITTRMRARRLQREAENPTFVSSSTPDSGLPGSSAPDPPRRSSSPLSSEGIDFLQRLTLVGLANTERLATAVSDLRRISRPSLRASTSSNLPNHEPPVDGIHVAAAPSADQTSNSSTMAVIQEDAAFTESLPEPSNAGSSRTLRRRGRSDALGSLDVDGGETHRNKRRRMN
The following text describes a protein:
Function:
Has a role in maintaining cell viability during stationary phase induced by stress response. Activated by the spc1 MAPK pathway.
Subcellular Localization:
Nucleus membrane.
Sequence:
MRSRSVASLGVLLAIVFYIFTYGFSTYRKNDTSAVKTWLEEHSIPYGSRSSPSDFQQFISESYDSLVPNLDKWSGHNLNSWLGKKTESSYLDAISNKIRKTGRKLSGSVEDARDATQEAWESQKASLFESWSDSQLRAFLARHSPQFAAKEKKGILEKLSPASLRETAAKEYDALTSKLGNTGDWIYDTWSDNELRTWLHDVGVPISSHESTRSHLLRKLKNYISTKADEAQPSVEAVKGKASEKAKQAGEFVSDKAGDAKELVNEKSSEAGQYAGQKMEEGGELLQEISKRRGRFGNWWANSGLKAYFDAHGIPAYQPSPIDQFYAHLRRQYYLKTNGYQALKSKAYEEASNVADSASSIASNVASGATEAYQGAASGASRFTEGAKTAAESVTSAFEHNKDTATSKAKQMKGKAASLGSTASEKVGEAADYAAETASKVASKAASKVRETIDETIIERWQDSKLKEFLFLRGVPVPQRSTKDQLLDLVRKHFNKGAVPNWAAYFDTLSSKELSAWIKEYKKHYHGKLHPSKDREHLFQNACNIYRAIAEKADKSVLQSIQSKFPKATVPGYDSWSNEDLKSALKEYGDSIGKVFNRKDAIERLKRHDILFYGPVVADKAKSGVSGFLRRVASFMGFGTRDVAEIKLGENIQKVKDTASKASSAVSSAGDYVETNVKKAQRVL
The following text describes a protein:
Function:
Acts as a chaperone.
Sequence:
MGKVIGIDLGTSNSAAAVMMGGKPTIIPAAEGQTAAGKAFPSVVAFSKEGELLVGEPARRQAVTNPDNTIIAAKRKMGSDYTFKIQDKEYKPQQISSFILQKIKKDAEAFVGETVEKAVITVPAYFDDNQRQATKDAGTIAGLDVVRIINEPTAASLAFGLDKAKEDMKILVFDFGGGTLDVTIMEMGGGVFEVMSTSGDTQLGGTDMDKVLIDYIVDEFKKKEGVDLSQDTTAMTRIREAAEKAKIELSTVMETDVNLPFIAHDPSSGAKNLELRLTRSKLDELIGPIVDRCKPSIQKALEDAKLSNSDINKIVMIGGPTRIPLVKKFVSEVIGKEVESGVDPMEAVAMGAAIQAGIIAGDVTSDIVLLDVTPLTLGIETLGGVREPLIERNTTIPTSKGKVFTTAADNQTAVTIHVVQGERPMATDNVSLGSFNLTDLPPAPRGVPQIEVKFDIDANGIINVTAKDLGTQKEAKITIETKTKLSEEEIEKLKEDAEKFSEEDKKKKEKIDLKNEAESYIYTTEKLVNHDLKDKISQEQGIKITDAVKEVKEVLDKEPEELKPKLEALQSIVNEVTTELYKNAAPPPGADGQQGADGQQGADGQQGADGQQGADGQQGADGQTTESSSNDETKTN
The following text describes a protein:
Function:
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
Sequence:
MDKQTAADRVAALRTELERHNRLYYAEDRPEITDAEYDLLFRELVDLETRFPDLAAPDSPTQRVGGAPLDKFEQVTHRIPMLSLENAFTDVEIADFDDRVKRFLGLHGDVEIDYVCEPKMDGLAVELVYERGILTVGSTRGDGVVGENVTHNLKTVRGIPLRLRCEQPPELLEVRGEVYLPLAAFQRLNAQREEEGEPPFANPRNAAAGSIRQLDSRITARRPLAIFCYAPGEVRGASFAAQTEFLDRIGEWGLPVNPLIRPVKGVAEILAYYREMTERRDSLPYEIDGVVVKVDSFALQRELGEKSRSPRWAVAVKFPPRQAVTVVEDIVPSVGRTGVITPTANLRPVEVSGVTVSRATLHNWEEMERKDIRIGDTVVIERAGDVIPAVVKVLTEKRSGSERPLPIPAVCPECGSEVVKIPDEVAVRCMGLSCPAQIRESIIHFASRDAMDMEGLGEKYIEQLLRLGLVKNVADLYTLTKDQFMQFDRMGDKLAENLLNAIEASKQRELSRFIFALGIRHVGEHTAKLLAGAFGSIENLERATEEELLSIREVGPQVARSIITFFRNEGNRETIRRMFKAGVRPTAEEKKVGGRFTGKTFVFTGALTRFSRPEAQKMVEKEGGHAAGSVSKKTDYVVAGAEAGSKLDKARQLGVRVLTEDEFLAMLEEG
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).
Subcellular Localization:
Vacuole.
Sequence:
MFDKLPYEIFKQIAWRIPQEDKISLTYVCKRSYESIIPFIYQNLFLNETYHINGDYDNSFGTCYWSVLNFHYIDEDDSNTKNDMSNRRLAKVKFSYFERTLAESPKRLCPLINRIRCTWHLNEDVMTNVLKLLSEYGSNLKFVDQFVRSSVNKGLEPLSKQLKTLTLTPPTLMPTHNSVSGSYLNKIDRLLLKCDLSRLEKLSIHINALKYFKNTGSPMKIKALVLNLRPDTLNLAEYDASDDFLKELEYIDIFDASTLRQLEILSWYSRDDFPSGEEGGFDRLYVKWGLEGFWKFPNIEKLSLASLVYSEFFLMNCLAVFHNLKILKLDYMGKFDFDVSLINFLSKQVCGKKLQRFDIHCQLNHRLFFPMTDNPLTRLNFDGFCPCSTCKNTIHEVILKKIFPETRSKLLKNPNKFQAHNFFYQMFFENKIMPYTNIIDNESPAMGWDSVPIETFVRKFNENLQSTIENTENITVNKITREDAISLYHLYLHYLKDVFKVFEQSLPNLEYLTINGIPTKIIQVDELQRCAVPLFYNNGYKSNSVYELVDAEALFS
The following text describes a protein:
Function:
Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MHLTLMNGTLRTAALSGRFALASPSPLPTATPLFQCCQKMSLRTQARPVSTSTTRILLKPSLRPQTSSMCLSPIFRKTAFRLNSTAANASRAEVPKLDWNSFFKLRASRRRYTLASSIIASMASTIIGVQILSEQDLESLGAQVMGLDPFVVLGLATATCGAVGWLAGPFLGNAIWRLVYRKYKPAFLMREKEFFDRIKRFRVDPSSNSIANPVPDYYGEKIGSVQGYRQWLKDQRAYNRKRRSFII
The following text describes a protein:
Function:
A caudalizing protein which is required to pattern the anterior/posterior (A/P) axis during central nervous system (CNS) formation. Inhibits anterior neural expression and acts as a transcriptional activator to induce posterior neural gene expression. Maintains a proper A/P balance required for hindbrain formation by activating the FGF/MAPK pathway, which modulates the planar cell polarity (PCP) pathway. Interacts with retinoid signaling during hindbrain patterning (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAQRYDEMVHYPGLDGMSLAGFADAHTGRALQHHSLSQSTPYGSTGAAHRVPMPPGMGSNDGLKREKDEIYGHPLFPLLALVFEKCELATCSPRDNSGSFPGGDVCSSDSFNEDIAVFAKQVRTEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHDLCDNFCHRYITCLKGKMPIDLVIDDRDGSSKSDLEDFTGSCTSLSDQNNTWIRDHDETGSTHSGTPGPSSGGLASQSGDNSSEQGDCMDNSVASPSTGDDDDLDRDKKRNKKRGIFPKVATNIMRAWLFQHLSHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRTGQGGAPYSPDGQNMGGYVMDGQQHMGIRPPGFQGIPGDYTAAPSTMPMGFPPAGYTPAIPPHSAGLRHGPSLHSYLPGHPHSMILPAGASPHHLVSAQSPADALLNGQNIDIHAH
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MAWHLLEKIVEHSAAHSTLLGKWWIAFMFVFRIIVVASIGDAVYSDEQDEFVCNTRQPGCKQICYNLFAPISHIRFWAFQILGTGLPSVIFIIFATHKLAVLPNKPHGKDSHNEVSTQTSPKHTTATRLRKRQLSSKHSRSSNCSKPSSSQDEAVFSDATAPPPPEYDGVCREKKLRRTKQLVLRAYILNVITRCIIEGGFLYLQYYLYNWTVPEFFECIRYPCPKIVECYISRPMEKTVFLYFMFAVSALCIVINIIEIHYLGWKRLKRALFRKQTQHVPPAQIIGAFPVEIDFPPKRDRRFRENREPPTRPSMGRIIHRRPEAAPPGYYIPDVDPPSEKYRSPANGFPPIRMRAASFTTSESDVTTDATMSSMGSVRNVMEENVRVYL
The following text describes a protein:
Function:
[Isoform 1]: RNA binding protein that mediates pre-mRNA alternative splicing (AS) regulation. Acts either as activator (FLNB, HSPG2, LIPA1, MYOCD, PTPRF and PPFIBP1) or repressor (TPM1, ACTN1, ITGA7, PIEZO1, LSM14B, MBNL1 and MBML2) of splicing events on specific pre-mRNA targets. Together with RNA binding proteins RBFOX2 and MBNL1/2, activates a splicing program associated with differentiated contractile vascular smooth muscle cells (SMC) by regulating AS of numerous pre-mRNA involved in actin cytoskeleton and focal adhesion machineries, suggesting a role in promoting a cell differentiated state. Binds to introns, exons and 3'-UTR associated with tandem CAC trinucleotide motifs separated by a variable spacer region, at a minimum as a dimer. The minimal length of RNA required for RBPMS-binding tandem CAC motifs is 15 nt, with spacing ranging from 1 to 9 nt. Can also bind to CA dinucleotide repeats (By similarity). Mediates repression of TPM1 exon 3 by binding to CAC tandem repeats in the flanking intronic regions, followed by higher-order oligomerization and heterotypic interactions with other splicing regulators including MBNL1 and RBFOX2, which prevents assembly of ATP-dependent splicing complexes; [Isoform 2]: Acts as a regulator of pre-mRNA alternative splicing (AS). Binds mRNA (By similarity). Regulates AS of ACTN1, FLNB, although with lower efficiency than isoform 1. Acts as coactivator of SMAD transcriptional activity in a TGFB1-dependent manner, possibly through increased phosphorylation of SMAD2 and SMAD3 at the C-terminal SSXS regions and promotion of the nuclear accumulation of SMAD proteins (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, P-body.
Domain:
The RNA recognition motif (RRM) domain mediates homodimerization (By similarity). The RRM domain also mediates binding to tandem CAC trinucleotide motif-containing mRNA (By similarity). The RRM domain is also necessary for interaction with SMAD4 and for TGFB1/Smad-mediated transactivation activity (By similarity); [Isoform 1]: The C-terminal 20 amino acids region, without homology to other proteins, is essential for higher-order oligomerization. Also essential for RBPMS cooperative RNA binding; [Isoform 2]: The C-terminal is required for TGFB1/Smad-mediated transactivation activity.
Sequence:
MNGGGKAEKENTPSEANLQEEEVRTLFVSGLPLDIKPRELYLLFRPFKGYEGSLIKLTSKQPVGFVSFDSRSEAEAAKNALNGIRFDPEIPQTLRLEFAKANTKMAKNKLVGTPNPSTPLPNTVPQFIAREPYELTVPALYPSSPEVWAPYPLYPAELAPALPPPAAFTYPASLHAQMRWLPPSEATSQGWKSRQFC
The following text describes a protein:
Function:
Transcription factor that negatively regulates jasmonate (JA) signaling. Negatively regulates JA-dependent response to wounding, JA-induced expression of defense genes, JA-dependent responses against herbivorous insects, and JA-dependent resistance against Botrytis cinerea infection. Plays a positive role in resistance against the bacterial pathogen Pseudomonas syringae pv tomato DC3000.
Subcellular Localization:
Nucleus.
Sequence:
MTMLWSDEDKTMVAAVLGTKAFDYLMSSLVSAECSLMAMGSDENLQNMLSDLVERPNASNFSWNYAIFWQISRSKLGELVLGWGDGCCREAREGEESELTRILNIRLADEAQQRMRKRVLQKLHMFFGGTDEDNYVSGLDKVTDTEMFFLASMYFSFPRGQGGPGKCFTAGKHVWLSDVMRSSVDYCSRSFLMKSAGMQTVVLIPTDIGVMELGSVRTIPESLELVHSIKSCFSSFLAQVRAKQAAPLAAVVAEKKNGNNSVFPSSFPFDQSKENPKIFGQNLESGSTEFREKLALRKPVDGPLEMYRNGNRAPIINTQNGVRPVSWASFGNVKPGNSVDLYSPQAPPNNLREFVNGGREELRLNSLQHQKPGGMQIDFTNSRPVVSPVPTVESEHSDVEVSCKEKHAGPADERRPRKRGRKPANGREEPLNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAIAHITDMQKRIRDAEYKLEKRGSTSVDAADINIEAASDEVIVRARCPLGTHPVAKVVEAFKETQVSVVESKLAVGNDTVYHTFVVKSSGPEQLTKEKLMAAFAGESNSL
The following text describes a protein:
Function:
Ammonia produced by ureolysis increases the gastric pH thereby providing an environment permissive for colonization of the stomach.
Miscellaneous:
MISCELLANEOUS: The novel dodecameric structure of the enzyme may allow it to remain active at the cell surface at acidic gastric pH. Within this dodecameric structure the 12 active sites are clustered within the interior of the proteinaceous shell. This may allow a high local concentration of ammonia within the enzyme which may protect the nickel-chelating groups from protonation.
Subcellular Localization:
Cytoplasm. Note=Also associates with the outer membrane upon autolysis of neighboring bacteria.
Sequence:
MKLTPKELDKLMLHYAGELAKKRKEKGIKLNYVEAVALISAHIMEEARAGKKTAAELMQEGRTLLKPDDVMDGVASMIHEVGIEAMFPDGTKLVTVHTPIEANGKLVPGELFLKNEDITINEGKKAVSVKVKNVGDRPVQIGSHFHFFEVNRCLDFDREKTFGKRLDIASGTAVRFEPGEEKSVELIDIGGNRRIFGFNALVDRQADNESKKIALHRAKERGFHGAKSDDNYVKTIKE
The following text describes a protein:
Function:
May regulate lifespan in response to food availability and oxidative stress.
Sequence:
MYIKAALLIVVLFGVASQITSALYLKQADFDDPRMFTSSFGKRSAIESEPQAYPKSYRAIRIQRRSMDDLDDPRLMTMSFGKRMILPSLADLHRYTMYDKRGSDIDDPRYFLFSNRLTCRC
The following text describes a protein:
Function:
Acetylates the N-terminal alanine of ribosomal protein bS18.
Subcellular Localization:
Cytoplasm.
Sequence:
MSIISQIEACDFERLYEIEQQAHLVPWSFGTLKNNQGERYLNLKLIENNQIIGFAICQTVLDEATLFNIAILPTYQGCGFGKLLLGKLIFQLKEKGVQTLWLEVRESNSARFLYEKIGFNEVDIRKNYYPKPSGGRENAVVMACYL
The following text describes a protein:
Function:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
Sequence:
MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRNHFWELIEERENSNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLDL
The following text describes a protein:
Function:
Chaperone involved in the maturation of iron-sulfur [Fe-S] cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HSCB and ISU1. In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions.
Sequence:
MATAALLRSIRRREVASTPFSAFKCLWSTGKASSNGSYHAQNWRSFSRAFSSKPAGNDVIGIDLGTTNSCVAVMEGKNPKVIENAEGARTTPSVVAFNPKGELLVGTPAKRQAVTNPTNTLFGTKRLIGRKFDDPQTQKEMKMVPYRIVRAPNGDAWVEANGVFPWRFIRVVSRDKVWFLGICGFVGGCGWGVFVERALIWIEGSSGFLWYVGQGRFMEGSYLSSACYRVALPVRCIAANRTLSSGGVPSISKNCSHLDNQSRSSVPSKAGKIIFERREVGECDSACDKETAEAYLGKSVKKAVVTVPAYFNDAQRQATKDAGRIAGLDVERIINEPTAAALSYGMTNKEGLIAVFDLGGGTFDVSVLEISNGVFEVKATNGDTFLGGEDFDNALLDFLVNEFKTSEGIDLARDRLALQRLREAAEKAKIELSSTSQTEINLPFITADASGAKHFNITLTRSKFETLVNNLIERTREPCKNCLKDAGISAKEVDEVLLVGGMTRVPKVQSVVAEIFGKTPSKGVNPDEAVAMGAALQGGILRGDVKELLLLDVTPLSLGIETLGGVFTRLIGRNTTIPTKKSQVFSTAADNQTQVGIKVLQGEREMASDNKLLGEFDLVGIPPSPRGIPQIEVTFDIDANGIVTVSAKDKTTGKEQQITIRSSGGLSEDDIQKMVRDAELHAQKDKERKDLIDTKNTADTTIYSIEKSLGEYREKIPGEVAKEIEDAVADLRSASAGDDVNEIKAKIDAANKAVSKIGEHMSGGGSAPGGGAQGGGSDQTPEADYEEVKK
The following text describes a protein:
Function:
May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MKLDYVLLLLFHLCFVNTELISVITGKIKDSGTTIAISAGAFWGLKDRLKCYLYECCHEPDVNFNYHTLDADIANLLFGQHLVKDVVVNSIKSHWYNENPRKPLVLSFHGYTGSGKNYVAEIIANNTFRLGLRSTFVQHIVATNDFPDKNKLEEYQVELRNRILTTVQKCQRSIFIFDEADKLPEQLLGAIKPFLDYYSTISGVDFRRSIFILLSNKGGGEIARITKEQYESGYPREQLRLEAFERELMNFSYNEKGGLQMSELISNHLIDHFVPFLPLQREHVRSCVGAYLRKRGRGDLVSNVDFVERVLNSLQYFPESSKAFSSSGCKRVDAKTDLEMAKIRPLLSSVHFDDEL
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGKKSYTGPTGAIVGTGTPPILPPNLVPSAPAPPQSRRPSNDRGYVVSRVVEDRKCRDVLFLILFVLFWIGMLIVAGSAFAKGDPRRLVYGLDYRGNLCGASDAQPNLVGFDTRYWMNPQQIYDSGNPLDPFSLSDARSICLKGCPEVSNTSLSWVCDYPEGPKPPVQDMETWAARNYDYYDLLTPQQKNFSANLQGPCYPVLLPSDNFFWSCQPQQSGLNTEAYATWRAAPVNGIQVASSNSQYYADAVKALLNQPAAILNRYVADLGRAWLVLVVCAGVAPFILGFVFLILMRFLAGLMTWLFIIGVNLLLIAVVLYTYAKAGVIGSDAVNALIGESAARQLDLTGTTGQEATDLKYVAIALTIFTVLFIIFTIIMIKRIRIAIGVVQVACKAIGHIPSLVFFPIFPVIAVAALGVYWVAVTIYLFSAGTIEPTQGCDIAGCCQYSVFNSTFQCGVENCCGYDIQYNTSMKWVLLYHLFGLLWTSHFVVGVSLCIIAGGVSSYYWSRGDISSVPLVPLFGSVYRTFRYHLGSVAFGSLLVATVELVRFIAAYLQRKLKEAGQGSWTKWLCCCVQCWLGCLEWIVNFINRNAYIMIAIKGKGFCSSAQTAAKLLFGNVLRVAAVNVIGDFVLFLGKMAVSLACAVFAFLMLDGERYKTGQDKISSPLAPVLFVWGVAFIIASIFFGVVEMAVDTVLLAFCEDCEENGGVPRYAPPLLMDALSRHAKALDEEDAQRKAQLEVELAKLNRPRA