lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Toxic component of type II toxin-antitoxin (TA) system VbhT-VbhA. Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific residue of host GTPases. The resulting AMPylation affects GTPases, impairing actin assembly in infected cells.
Miscellaneous:
MISCELLANEOUS: Defined as class I fido-domain containing proteins, in which the inhibitory helix is provided by an interacting antitoxin (VbhA).
Domain:
The fido domain mediates the adenylyltransferase activity.
Sequence:
MRKYEGSNDPYTDPETGVMYNLLGIKDQARLERVESAFAYIRSFELGRTSISGKFDLDHMKKIHKKLFGDVYEWAGKTRLVDIVKDNSKFAHYTQIESYAPQITQQLAREQHLRGLDANEFSQRAGYYMGELNALHPFREGNGRTLREFIWQLAREAGYHIDWDRVERQEMTRASIESYYGNSDLMSALIRRNLTEFTVNRRVDVSQGINERVLSHIDIDKEWPQKGFNIAIQTTQQAPYLSSYTDTSNLEEKAQNALRNEQSYVDTFKELNDHLKTIYKDPQAAALKIEQTILAGKGDKLPDILAKAPNKVGELRGSDRLIDKLKSAGKERKAALYNVPLAISTIRRLQSFYKNSYEKHMDKLTREREQLKVEVPSLSQEAVAYMKNVEVGRNNYSKIPENINKEFVQLESALNRRFGKDVIYKRNFNLSKEIASKQTYDKKLVNELQTAIKFLQQRHIQKQNNLAITRTPSKGITR
The following text describes a protein:
Function:
Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.
Sequence:
MGRRRSHERRDLPPNLYIRNNGYYCYRDPRTGKEFGLGRDRRIAITEAIQANIELFSGHKHKPLTARINSDNSVTLHSWLDRYEKILASRGIKQKTLINYMSKIKAIRRGLPDAPLEDITTKEIAAMLNGYIDEGKAASAKLIRSTLSDAFREAIAEGHITTNHVAATRAAKSEVRRSRLTADEYLKIYQAAESSPCWLRLAMELAVVTGQRVGDLCEMKWSDIVDGYLYVEQSKTGVKIAIPTALHIDALGISMKETLDKCKEILGGETIIASTRREPLSSGTVSRYFMRARKASGLSFEGDPPTFHELRSLSARLYEKQISDKFAQHLLGHKSDTMASQYRDDRGREWDKIEIK
The following text describes a protein:
Function:
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Subcellular Localization:
Nucleus.
Sequence:
MSGDHVHNDSQIEADFRLNDSHKHKKDKEHRHKEHKKDKDREKSKHNNSEHKDPSEKKHKDKHKNNDKHREKDGEKHREKDGEKHRDKNGEKHDKHREKDGEKHKDGEKHKEKDAEKHRDGEKHKDKHRDKDREKRKEEKMKSSSGSVKVKKANGFSSPVRVKDEPEDDGFHMSPKENKAMKRPRDDDEDYKPKKIKSEDEKKGKKRKQEEEDIKPKKKSKGKGNEGEVKKKKVKKEEEEKWKWWEEERHADGIKWKFLEHKGPVFAPPYEPLPDNVKFYYDGNLVKLSPKAEEVATFFAKMLDHEYTTKDIFRKNFFKDWKKEMTADERNLITNLGKCDFNAMSQYFKEQSEARKNMTKEEKQKIKEENERLLQEYGFCVMDNHRERIANFRIEPPGLFRGRGDHPKMGKLKKRIMPEDIIINCSKDSKYPVAPAGHKWKEVRHDGKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKMCVEKIRNTYKEDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLFQELDGQEFVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPDDDLFDRLNTSILNKHLQDLMEGLTAKVFRTYNASITLQQQLNELTNGDDNVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQGKIDAKKDQLMDARRELKSAKADAKVKRDEKSKKLVESKKKAVQRVEEQLMKLEVQATDREENKQIALGTSKLNYLDPRISVAWCKKYGIPIEKIYNKTQREKFAWALDMADEDFAF
The following text describes a protein:
Function:
Has a role in modulating the nuclear import of TF1 virus-like particles. Essential for viability.
Subcellular Localization:
Nucleus.
Sequence:
MAKDWQDARLGQCHRLEDYSNVAINYTGPYLTPSGTMAYHPGNAPLFTQAPPHTNPQGPPPFPLFNSISPVYDPATGRLLYRNVNTQVSHTAIPNPANGYAAVYGGPPSQLPPPPQPQSHPNVTVISASPARAIEQQPTILSSTDSNIPRPGTVKSSASPFVPNQNPSAPPPPPQEYRQLNVTDALSYLDLVKLQFHQEPEIYNEFLDIMKEFKSQAIETPEVITRVSKLFAGYPNLIQGFNTFLPPGYSIEISSADPGSLAGIHITTPQGPLMINDLGKTTAPPPPHGSTTPLPAAASYTSMNMKQSSASHPVLQPPAPSTLQFNPSPSPAAPSYPPVDASVKQAADLDQAINFVNNVKNRFSHKPEAYNSFLDILKSYQHDQRPIQLVYFQVSQLFAEAPDLLEEFKRFLPDVSVNAPAETQDKSTVVPQESATATPKRSPSATPTSALPPIGKFAPPTTAKAQPAPEKRRGEPAVQTRNHSKRTRTATSSVEETTPRAFNVPIAQNKNPSELEFLEHARQYLANESKYNEFIKLLELYSQEVFDKNALVERCYVFFGSNEHLMNWLKDLVKYNPANPIPVPRPRVDLTQCKSCGPSYRLLPKIELLLPCSGRDDLCWTILNDAWVSFPTLASEDSGFIAHRKNQFEENLHKLEEERYEYDRHIGANMRFIELLQIHADKMLKMSEVEKANWTLPSNLGGKSVSIYHKVIKKVYGKEHAQQIIENLQKNPSVTIPIVLERLKKKDREWRSLQNHWNELWHDIEEKNFYRSLDHQGVSFKSVDKKSTTPKFLISELRNLAQQQKVELSEGKVTPSHQFLFSYKDPNIITDIARLFGVFLIHGSTHSAEDNEKMSNFLRSFLSLFFDVPYDSFIPYLPTHFNEEESDIDSLSSSLIEKPRASSSPIHHANNNGLRLLKDVLKKTYRGARENRSSVKEDYVSESTERTPDASEIDEHISEHEENDDESSSVFSTGEVWVNCKFTDTDGSLLDDGTKLSDRSVYNLFGNMSLYCFFRLFHTLYSRLEEIKNLEQMAYSKQHDVKSNPVAVELGLVRHPSERLGFALPTADTVYEQAIQLCERLMEGEIDQNGFEDALRCLYGIHAFRLYTVEKLVTSIIKQLHSVTTNRRLAQVFMYYEKDRVQRRTSPRQQIMYRIQTETAFGPDENLCCIDWNSQTRQSAIRLMGREDLTMGTLKSDAEKWCYYIGSYIMSSPTEGILPEHVRIPFLRKCLPSDEGNEDDESSSVVKSANAIITSFLESGLALTIPINTVKIRYENGTEDVFARNSEQVYNGPYDKIRDYRQSKWREWLNSDEGWTQGLSKDKVRRIKPCTIESLFNESTLRSGKAERFSENAGVESIGKKGKNLLNESGNGKKLDKGLPPKVNGKSSVTRGNKTNLKARNGRNNDDSSNKINLSEKEKEKESIEDEEKNREGSMSPVAKHASDVEDDHDVAKSTAPDFETSSHRPERSSEKKSPSPVFTSVKQTAENDADNEDDKTDMDDQTEETLDADNTMEEEPSKDDL
The following text describes a protein:
Function:
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane.
Sequence:
MAATTAVAASYFSGTRTQYTKQNPGKIQALFGFGTKKSPPPPPPKKSSPKQFEDRLVWFPGASPPEWLDGTMVGDRGFDPFALGKPAEYLQFDLDSLDQNLAKNLAGDVIGVRVDATEVKPTPFQPYSEVFGLQRFRECELIHGRWAMLGTLGAIAVEALTGVAWQDAGKVELIEGSSYLGQPLPFSLTTLIWIEVIVVGYIEFQRNAELDPEKRLYPGGYFDPLGLASDPEKIENLQLAEIKHARLAMVAFLIFGIQAAFTGKGPISFVATFNN
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MGMRIKLQSTNHPNNLLKELNKCRLSETMCDVTIVVGSRSFPAHKAVLACAAGYFQNLFLNTGLDAARTYVVDFITPANFEKILSFVYTSELFTDLINVGVIYEVAERLGMEDLLRACHSTFPDLESTAVAKPLSGTGESHPGTQSCSSAEPAYPLGDLRGAGEHFGPDRNYVLPSDGGGSCKEEERNVTGDINQSLPLPQQPLPPKTEEHDAPAPFTPAPGVVTTQPVLGTVNMSIQTSTSSCQPYKVQSNGDFSKSSFFTPDNAIDITTGTNSCLSNSDHSKDPSFGQMDELQLDDLGDDDLQFEDPTEEIGTAEEVIELSDDSEDELTFGENDNRENKAMPCQVCKKVLEPNIQLIRQHARDHVDLLTGNCKVCETHFQDRNSRVTHVLSHIGIFLFSCDMCETKFFTQWQLTLHRRDGIFENNIIVHPNDPLSGKLGLFSGAASAELKCAACGKALAKDFHVVRGHVLDHLNLKGQACSVCDQRHLNLCSLMWHTLSHLGISVFSCSVCANSFVDWHLLEKHMAVHQSLEDALFRCHLCSQSFKSEAAYRYHLSQHKCNSGLDARPGLGLQHPAFQKRKLPAEEFLSEELALQGQPGNSKYSCKVCGKRFAHTSEFNYHRRIHTGEKPYQCKVCHKFFRGRSTIKCHLKTHSGALMYRCTVCGHYSSTLNLMSKHVGVHKGSLPPDFTIEQTFMYIIHSKEAEKNPDS
The following text describes a protein:
Function:
Transcription factor which may be involved in developmental processes.
Subcellular Localization:
Nucleus.
Sequence:
MRLHHLHVAYLDHKASSSSSSPAPPSISPSSIPGSAAFPAFSFKCLRPLAPKISLPEPRKMIAPPDFVVPRARNASKLLNYTVQVPAAGTTRWNPSAEQIKVLEMLYRGGMRTPNSVQIERITEELGKYGRIEGKNVFYWFQNHKARERQKQKRAALLTLSTLDPSLLPATANETKEAPEKKEKDVEDGLASCKRRCKAWGDGAGDGDAVVATEAAGGCTDEVTLELFPLHPQGKA
The following text describes a protein:
Function:
Receptor for the cleaved activated form of spz, spaetzle C-106. Binding to spaetzle C-106 activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin. Component of the extracellular signaling pathway that establishes dorsal-ventral polarity in the embryo. Promotes heterophilic cellular adhesion. Involved in synaptic targeting of motoneurons RP5 and V to muscle 12 (M12); functions as a repulsive cue inhibiting motoneuron synapse formation on muscle 13 (M13) to guide RP5 and V to the neighboring M12, where its expression is repressed by tey. May also function in embryonic neuronal survival and the synaptic targeting of SNa motoneurons.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=In the fat body, detected in puntate structures along the cell periphery. Becomes evenly distributed in the cytoplasm 1 hour after bacterial infection.
Sequence:
MSRLKAASELALLVIILQLLQWPGSEASFGRDACSEMSIDGLCQCAPIMSEYEIICPANAENPTFRLTIQPKDYVQIMCNLTDTTDYQQLPKKLRIGEVDRVQMRRCMLPGHTPIASILDYLGIVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHLELRANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILRLRAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMCVNAEMPTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDEELKAYLKMNTYLKWGDPWFWDKLRFALPHRRPVGNIGNGALIKTALKGSTDDKLELIKPSPVTPPLTTPPAEATKNPLVAQLNGVTPHQAIMIANGKNGLTNLYTPNGKSHGNGHINGAFIINTNAKQSDV
The following text describes a protein:
Function:
probable ATP-dependent RNA helicase which may bind to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures.
Subcellular Localization:
Nucleus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSKRVSAFGAEGDDEPQEKPMKPFISFSSNINNNNNSNNNNNNNNNNNNNNNNNNNKNNIGTGINLNIKNNNNINNNNNKSGFPVKKSRFNGEDDDDDYFFSNVPPKSSMTTLNKSPPNFENASSNNNNNNNNNNQESDSKNQNEDEDDEIDPLDAFMENVNAQAAIDNSKSIEKGQQQQQSLKSKRDDIDNEDDEEIFYKLRQKQLANKSSKQQQDDDVDYSSLDDDDGYFDDEESLKNGQSKGKRIIEPLPPIDHSKEEYIEFNKIFYEEHPDIANLTEEQVFEIRKNLDIRMTGTDLINPVTSFGHYGFDDILLQAIAKQSIETPTPIQKQAIPIALSGRDLIAIAKTGSGKTATFIWPSISHIMDQPYLEKGDGPIALFLAPTRELAHQIYLETLKYSKYFKLKTTVLYGGVSKQQQCKELKAGCEIIVATPGRLIDMIKLKATKLNRVSYLVLDEADKMFDFGFGPQVLSIVNHVRPDRQTLLFSATFKPNVEEFARTILSDPIKISIGMIGSANSDITQIVQVLKSDSDKWNWLTNQLALLLSQGSVLIFVSTKVAVEQLSSNLTKFGFQTCTLHGDKNQIERSQTIQTFKEGKINILIATDVAARGLDIPLIKNVVNYDTSRDIESHTHRIGRTGRAGNTGVAYTLITPKDIHFSVDLIKNLESASQFVPPELIDVAMNNPHFKRERGGGGGGSNRGRGRGGGGVGYRRNSRGGGVAFNSNRDSSRSDSQNKFIPAQSVEGGRLFNPNNTDNSEINNENEKSINNENKFSNNNSGSSNDRNSINYRNNSFNNNSNNTNNSGNSNFNNSNSNNGYSNNNYNNNYKNNSNYNNSNNNNNSYYNNNNSNNNNNSNYNNSSNNNNNNNNNYRNGNNNNNYNNNNYYNNNNSNNNSSNNNNSNNNSSNNNFNNNFNNNNNNNDNSNFNRALPFNDFNNNNNNSNNNNFNYNNNFNNSYNANNSNHYKNNNNSNNFNQRSQYNRR
The following text describes a protein:
Function:
May be an essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.
Subcellular Localization:
Secreted.
Sequence:
MKRLILPFLSVGLLLGTTAHAATPLKTEQDKLSYSMGVMTGKAFRKHDIKIDPQTFSMGLSDAYLGKETQMTEAEMRQTLQQFEKQSLQKMQHKMKQTAQQNAEKSRAFLTANKNKPGVKTLANGLQYKVLQAGQGQSPTLNDEVTVNYEGRLINGTVFDSSYKRGQPATFPLKSVIKGWQEALTRMKPGAIWEIYVPPQLAYGEQGAPGVIGPNEALIFKVNLISVKKK
The following text describes a protein:
Function:
Acts as a magnesium transporter; Acts as a plasma-membrane magnesium transporter. Can also mediate the transport of other divalent metal cations in an order of Ba(2+) > Ni(2+) > Co(2+) > Fe(2+) > Mn(2+).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MVVPKPLNKKQSESGKVSGLSFMHLSDSIKQFNFGKNLSPTDAVIQFEPRECSETDALLSSRAQGTTTRKDAGRSAEPLCSMVLQILVPFLLAGLGTVSAGMLLNVIQSWDVFLEVTEIFILIPAVLGMKGNLEMTLASRLSTAVNAGKMENPKEKWALILGNLALKQLQATLLGFLASFLAIVLGWMAEGELSLKHVVLLCSTSVSTAFVASLLQGVLMVGVIVGCKRMNINPDNVATPMAASFGDLITLSLLAGFSHWFYSLMGERKSTGFHGPAVSPSPADGSCSQHPDLWDVSQAWVVNAVHLCVADFYPYVLYLVNLSYICLIPVWVAVSSKHPASLLLLRSGWEPIVTAMVISSLGGLILDKTVSNQNLSGVVLYAPVINGVGGNLVSIQSSRISTNLHLNFSPGELPEERRGCFNPCRIFFGPGANHQSARVLLLLVLPGQLLFLFTVYLMKGGLTAPSPLLTLFYLSASLLQVFLLLCLADCMVHRLWRRGKDPDSYAIPYLTALGDLLGTALTSLAVFLLWCIGD
The following text describes a protein:
Function:
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MTLLARFVPFLCAILALGASLVHAEDFLTCGGFIKSEIQINFARIEVKLYTKQGALKYQTDCAPNNGYFMIPVYDRGDFVLKLEPPSGWSFEPTSVDLKIDGESDPCSQGKDINFFFKGYTVSGKVVSKGKADGPEGVLISVKPKDKDAVAIETRTKTGGVYNIPNVLPGDFIITASHPTWTFQKASITHTVTKDTATVDSPIIVSGYDVRGKVMSEGEPIKNVFFILFSDTVKPEDVAGCQKSVVNGYQSEGKSPLCHVQSDVDGQFVFPSLGSGVYRVVPFYMGEHTTFDVVPSSLQFTVEHNTIQLPTVFQVAGFSISGRVLSATGGKGVEGAKVKVQGKPEVTTRSDGTFRMEKIKSGTYTLKASKEHLTFDPLNVKVTPNTPKLPDIVASKFSVCGRVETSAGGQRKVSLTKEGSKQPEIATTDKDGAFCFSAAPGAYVMEPMMSEVEQAAGLRINPESQKVTVSSSPVLDINFSQFKATLRGSIKCLDVCGTLQLMVESKDGRGFKKPVPVSQQTKQAAFIIKDILPGKYSISVVQTSWCWSKSSLDVEVVDQDIGGLEFQQSGYVLHCHVSHPIELVYSLDPSASYKGSFTLNKGVNQFCLEKPGSYKLTPKSCHQFEKSEYTFQTSAPNMLTLTALKHQIHAEIRTTQPVLDITVSISSGGKLEQTVKLGPLKSRQQLEQESKPPAKKSVNETAEKKPTPSPSGPQVYDVSHWAGNGEVLEIAPSSGEFLFYPSTVKVTVESGEKCPGVVAEFEGRPGVFITGQVTPPLSGVKVTITPTNPAEGSTDGAITQMTDNKGQYRVGPLPDTSEYEVEASLDGYIMSQEEGKLGYFRAFKLGKIRIEVTDGENSPLSGVLLSLSGGNFRSNNLTKDDGILTFGDLGPDTYFLRALMKEFEFDPSTQMIEVSEGSAVDIKVKGRRVAFSCFGSVTSLNGEPEPGIAVEAHSEESCGQVVEEGVSDEEGNFRIRGLQPNCDYKIKLKDCESNGHIERASPPTQTVAIGQKVIKDLRIIVFRHLNQFDIGGNIVTPHEYLTSLKVSLYSEEDPETPIHTLPLDMGSFFQFSSVPNDGRRYMIKLESTLPRSKYDYTLPEASFTSTGYQKHVTLPFNPQKRALEQEVMQGSYFALPLVVALIAVGVNHAKIMPFILQFRQNMRGLQSSGPTSRSETVNFDADLSRQRKKVKPRKT
The following text describes a protein:
Function:
Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MGCMCSNVSTEDRSEEPLNEESVVKQYSWDKRESIRQRDNVVSSIQGLTNETVVRVPGSSCGQQIIIRNCQKCFIYILDNLSSVLVEDCKDCQMFLGPTETSVIFKDCESCKVLSASQQFHCKTSQTMDFFICCATRPIIENSRNLKFACFLFYYPQLEGWLEPKLENIFTVPECFEGLGVKLGGRDTIVPYMPSKKNPPSEKSCLVMFFNDGLSHDRARTFIKLMRENHTGCSLVQGRELVLKEIESSEIFNSDKYTMAVKQGPVICLEYCGVDCRHFCQETLVAVSKGSTGLVFISAARDHAQKQVEAFRRLAESKLGNVKTPENFKKRA
The following text describes a protein:
Function:
Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. Has ribonuclease activity.
Subcellular Localization:
Nucleus, PML body. Nucleus, nucleolus.
Sequence:
MESLPFDLNWTLDTLRWKESSLGNNSDHSVRNGDTFDLGYGSLNWASTRSRSHKDKKDEQEMSADKSSSPAPDLGEMQMKVDFFRKLGYSSDEIQAVLHNLGVQADTNSVLGELVKHGANPERETIPDESSETFLASRGVLGSRCTPSVPSSEDNDGNNLRPIVIDGSNVAMSHGNKQVFSCRGILLAVNFFLDRRHTDITVFVPSWRKEQPRPEMPITDQHILGELEKKKIVVFTPSRRVGGKRLVCYDDRFIVKLAIQCDGVIVSNDTYRDLQSEKVEWKKFIEERLLMYSFVNDIFMPPDDPLGRHGPNLDDFLRIKPLGVENKKVQCPYGKKCTYGIKCKFYHPERINQPQRSVADELRENARLSPTKSPLDDRKSRQHSLADVPPLDSEGPPLQKLPVERTSSLQKSRVVDNMAAKQFFYTNAKDSLPRNSLDSGIEVWASISNSYCDSSHDPVVYGKYCNCTQRHCCQHRHDLDTDGCQPYNYQKPIQCSHSSAPYFPYNTSSQWSPQNISHPIYRDLPKTGHNGNHSLPNDYNPPPTHSIDYWSEPNPIPSSGRHQSSYPVYPQIPPSATDLPQWSSSDPFSAERLSVRTKLCAIFQPSLVDAVMRKFPQLLDPQSLAAEIFTYRSQHNM
The following text describes a protein:
Function:
Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors (By similarity).
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
Domain:
Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Sequence:
MPNFSGNWKIIRSENFEEMLKALGVNMMMRKIAVAAASKPAVEIKQENDDTFYIKTSTTVRTTEINFKIGEEFEEQTVDGRPCKSLVKWESENKMVCEQRLLKGEGPKTSWSRELTNDGELILTMTADDVVCTRVYVRE
The following text describes a protein:
Function:
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
Subcellular Localization:
Cytoplasm.
Sequence:
MTETRRLRILITNDDGIKAKGISLLISLLREADFADLYVVAPLEEQSGRSMAFSLVEPTALEPFDYPQRVQEAWAVTGTPVDCVKLAIGELFKENALDLILSGINNGKNSGRCLYYSATVGAIREANLHGIPAIALSQSENIAFFQKAHMASLIRSLCEFTVAYKHTDPLGLNVNFPASTDDSPWKGIRFTLSGNEFLFGIPRLVRTEGNRRYYTLYDMRDKVSEEFSEEYLALANNYISAAPLVSKNTPRATLSEEELAFLKDSFEQSVLWKASLNLEEDLA
The following text describes a protein:
Function:
Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR).
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
MKDRLQELKLKAKQLQLLEESSASPGIVAEEGELEQTAVIFEKEPVTERYLSEIQQLHSDINNLATDVQKFSQQQKSLVASMRRFSVLKKECSATREIKTQAEHISTCLDNLSKTVKKTEKEYGSSSAVGRVLSSQRAVLFRRFQNIMFLYNDAITAKQEKCTGFIVRQLEVAGKQVSEDELNEMVQQGKWEIFNENLLTEVKITKSQLTEIEQRHRELVNLENQVKDLKGLFIQISLLVEEQGEMINSIEMEVTHTEDYVQASREKFQLAAKYRKKNPCRALCCCCCPCR
The following text describes a protein:
Function:
Component of the CCAAT-bound heteromer, php5 is essential for DNA-binding activity. It is essential for transcription activation of cyc1. It is the linchpin that binds to the subunit association domains (SAD) of php2 and php3 to bring these proteins together.
Subcellular Localization:
Nucleus.
Sequence:
MNSIPDSYSLKQGFPEGLGEYVDPSGNPNSQVRIGYGQDSVSRFQQPVPDVDPTAVNHYNASAPIEVASPFDNVTQGLVGSDAQALAEYWQKTIDTLEHDDQAVKTLHLPLARIKKVMKTDDDVKNKMISAEAPFLFAKGSEIFIAELTMRAWLHAKKNQRRTLQRSDIANAVSKSEMYDFLIDIISKDNNNSRASSSQAHMSATQVAAMGGMNGLQPFPTQAGLPNQGFPMPTGSQLPFSNQQSSQPSMQYSSHPSRMQQMQDIDQSMYKQQRLGSEYPQLQMSDNSGNVNQMNMQRPVMVAPYMAEHLYRYPPTHLESGSSAFRLQSSPMGYQMPQFQGNMRPNMQQSQMFDPSAYGMSRRPGSPRQFDQQQRLYSQPNAMMYQTQQGRQGNPMHQQFSQQQNPLSRYSQQPQ
The following text describes a protein:
Function:
May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Nucleus, nucleolus.
Sequence:
MDIEVDIIEFKVPLENNKTIFIWDIQPTFTEAYIYESLWSVYSAFGDLYLLKVCPNATVAEPGFYALVKFYSSAQASKAQRATDKQCLFQSSPLKVRLSTKQNLSFYSSKPLCLSKCHNLANHYLGFGGWTTRIVTLKDLSNCVDAGCQEETGDQGVLLKYGCIMELSFPHHGMSCQGVGVAEEVLDSDQDPEEKLRKRGALMKRAKDKAMEVAFEKVLLLILGNGKVAIEIKIDPDEIVPEENSERVIKVNDISWTHIESADSNAEEDFLWDLTEDLPY
The following text describes a protein:
Function:
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MTQDILHRYLFDNADVRGELVQLQNSYQQVIGSHAYPPVLQTLLGELLAATSLLTATLKFSGDISVQLQGNGPVSLAVINGNNLQQLRGIARWDGELADDASLADLFGQGYMVITLTPDEGERYQGVVALDKPTLAACVEDYFNQSEQLPTALWLFADGKQAAGMFLQILPSQEDHNADFEHLCQLTATIKAEELFTLEAQEVLHRLYHQEEVRLFDPIEVSFKCTCSRERSAAAIKTIDQAEVEAILAEDGNVEMGCEYCNAKYLFDAIDIASIYANGTASNTQQ
The following text describes a protein:
Function:
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MRLPCAPSLALRAARTPLAFARNGQKHSLHTGTYNAAVIGGGITGLATAFRLSQDPKCTHITLYEKQQRVGGWMMSETIPLGDDDGKVVFEYGPRTLRAAAPTCLPLLDLLVELELLEDVLITTKSSPAAQNRYIYYPDHLVRMPGRDPGRSLFSELYSNFRTLLTEPVFDKLVRSVVTEPARLPPGPKSVDSDESVRDFISRRLAPEIADNIVSAVYHGIYAGDIDRLSAQTLLGTYRDLEHDDRRVIGGLVHAATSDITYNLMDDWLALHSLAATKQKSYWSSLKTLVRDASVITFKNGVQQLTDALAAALRKSRKVDLLTGTEVMAISTNPANSDLTIHFGEGKSNTHNRVIATNPPPNLAQQLAKPTRSGQRLPQNSIRQLQEHNYAVTVMVVNILYENPNLLPVKGFGYLIPQSVPFEHNPEMALGVIFGSESSVGQDTVPCTKLTVMLGGHYWDGWKTSDYPDPDTAIGMCQTLLHRHLGITEKPLQAAVKLQRQAIPQYTVGHLSRMRDLSQTVRQDFNNRLTLAGNWYNGVGVTDCVQQAYMAASYGVGALKLDAPSVNVPWIRYNWQGWELEGGIPTSPVRITETYRSERNYFF
The following text describes a protein:
Function:
Has a role in the formation of the multivesicular body (MVB). Required for the sorting of lipids to form intralumenal vesicles and for fluid-phase transport to the vacuole. Required for sorting several plasma membrane proteins into the MVB (By similarity).
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein.
Sequence:
MIQIDTIPKELQSIQPFVRRFNELEAHNPVIAYWSLYWAAQMALSSSHGVSNECKDFLLSLIEHLEDLRKNLGENENVSDETSAKAYVESFSLEVLVQAERNSKNGKPDVQAYLAARDFLELSRIWGPPTEQITKSIKFCKLRALQVANPQRKAKTPSNHATEELQQSSTNSTTLPTQEAAVETNASASHETSFALPTTSPAASLSISPTKSAAVSSEPNVEADVKSLSSTPAAPQLNSPSHSYEPTTFPSTTSITENLPTIDPTRSTRSSSHIQSLSPESKQTSDGHRPPSPTSITTTSTSIDPSVAFSSKSTLATTRTNAPLSRPSQPTKASPLNKFSALEAIQSARSHARYAYSALDYEDTTTAIHHLKSALKLLEEEEQGNHTAD
The following text describes a protein:
Function:
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Localization:
Nucleus.
Domain:
The F-box is necessary for the interaction with ASK proteins.
Sequence:
MDVFDGLPDPIIVDILNKVGDVKTLLRCSSLSKRFNSLVPQSESLTLRLDHSVSDSPVVTSIFRSLFNGLVSLLSKPAKPITITTLSPSLPFKILSRFDRIRNLDVELPGGDVKLEKGAAVKWKAEFGKTLKSCVIVAFRSAGTVSSPVAVEGESDAEFVTGLKTRVVWTISALMAASSRHYLMREVVKEHEEIESLVMRDKEREGTVVMNEEGLKELRNTEARVEDEERVVKNKRSVVPSVRMSMRHAPSLKLKSGICLESATLVIVRPSGADFEVGDDAELATEAFVGDCMYGEAVVALLKCKKNALEMNSF
The following text describes a protein:
Function:
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
Sequence:
MVDIIIAEHAGFCFGVKRAVKLAEESLKESQGKVYTLGPIIHNPQEVNRLKNLGVFPSQGEEFKEGDTVIIRSHGIPPEKEEALRKKGLKVIDATCPYVKAVHEAVCQLTREGYFVVLVGEKNHPEVIGTLGYLRACNGKGIVVETLEDIGEALKHERVGIVAQTTQNEEFFKEVVGEIALWVKEVKVINTICNATSLRQESVKKLAPEVDVMIIIGGKNSGNTRRLYYISKELNPNTYHIETAEELQPEWFRGVKRVGISAGASTPDWIIEQVKSRIQEICEGQLVSS
The following text describes a protein:
Function:
Enables the bacterium to metabolize sucrose as a sole carbon source.
Subcellular Localization:
Cytoplasm.
Sequence:
MAFERSFKKVDKKNAYSQLEKANLFVKEHKKYVNPKYRLVYHLMGEYGWINDPNGFIYFNGIYHCFYQHNPFNSCWGPTYWGHAISEDLVKWQYLPIALAPDSEYDKDGCFSGSAIEKDGKIYILYTGHVKKSDEEYMQTQCLAWSNDTINFIKYEGNPVIGLDKIPGGASKKDFRDPKVFKRGDKYYVLVASKDLNGKGQILFYESHNLIDWNFVNILFKSDIDREHILECPDFFSIDNKDVLIFSIQYIENNKVIRSETRYCTGLIDWNKGVFNLEYCDLIDYGTHFYAPQTTLGKNGCRVMIAWMDVWEREFPTHKLGHNWAGALILPREIYLKGNKLFFRPIKEIEKYRKNEQIFEGVLEGEHIRLPLEDNCFELDMTAEFFVDTEMNLELLSREDSGNDLIKLTFKYSFGVLELTVTIRDSVNNNENQSLLIDSLSSRLNLRLFMDKSSLEMFINEGEKVITKRVYPFKKYDLINISSQNACKVRLKKWNLQIT
The following text describes a protein:
Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.
Sequence:
MNSNVENLPPHIIRLVYKEVTTLTADPPDGIKVFPNEEDLTDLQVTIEGPEGTPYAGGLFRMKLLLGKDFPASPPKGYFLTKIFHPNVGANGEICVNVLKRDWTAELGIRHVLLTIKCLLIHPNPESALNEEAGRLLLENYEEYAARARLLTEIHGGAGGPSGGRPEPGRATASGAAASTADPTAPGGPAGAEGPMAKKHAGERDKKLAAKKKTDKKRALRRL