lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MCGSSQGFTASSRECTKAMLASETSPEGFPIPENQDLDMTLWSEKDFEEKYIYTVKDHRFEEESENSCKTRAERSLPRNLALKRCHNPPEQVLGVISKELIPKGTRFGPFVGERYTNDTLPKDANRKYFWRVFVGRNLHHILDGLNEERSNWMRYVSPARTVEEQNLVACQSGLDIYFFSIKPLLPSQELKVWYCPEFAQRCHYLPLEQPMVNKNEQSNAHEKTSGKRGHSVSEILREEPAKSRLSLPGCLDDSSSRIYVPAVLPLCPSVLYPVQPFSESIYNHGYAPLPPLPPCSPPTAKRQALSISLPTSLHFALQPSQAYRESYVPDHITSAFRHGSFPLPHYSLGLLPHSYSLYSDRLKPPFAVSSNPSPFDSHAMFLNPLTSDCKGLPQVPSSSKSNLKLTIEQKDSKDLTSQRTTYLRSSSDDLRVLKSSPRSNAGMDHSVPSKAGISPINTELCGSLSSFAHGGCSPPAGMGAPSSCLPSKPTSAIQSITEDALDLRKTKQEGQIIGYKTLSYPLTRENGKIRYECNICKKIFGQLSNLKVHLRVHSGERPFKCQTCNKNFTQLAHLQKHYLVHTGEKPHECKVCHKRFSSTSNLKTHLRLHSGERPYQCKLCPARFTQFIHLKLHKRLHTGERLHRCPHCSCAFLHYCSLQVHLQGFCPLSPSASCRYSPEELHRFNCEIERFDSSEAAEQLEVLSAGIDMERGNIFDLIKKIQTGVLSHLEGVEGETELSLCKSAKKSCEGQLHRISPLCLNPSRIKLESGCVSET
The following text describes a protein:
Function:
Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
Sequence:
MSACACDGGQLRPLDEALAELLARAPRPPACESLALERALGRVLGEDLLAPMDLPHWDNSAMDGYALCSADLPRSGGSLTVGARIAAGDTRGMSLPLGQAARIFTGAPLPTGADCVVPQELCVVDGERVQLPPVSAGQHVRRRGEELRRGAPVLRAGQRLRPQELGLLASLGVATVSVRRRLRIGLLSSGDELREPGQTLLAGQIYNANRYCIGALLRGLGFEVHDEEVLADELVASRDALSLAASEWDALVTSGGVSVGEEDHLKRAIAELGEVNLWRLAIQPGKPFAFGSVAGKPWLGLPGNPAAALVTALLVARPFLLRQQGLFDVVPRPLALPAAFDWPQPRARRQYLRARLDERGRVEIHPQQGSAMLLAASWADGLAVIERGATLGVGDAIDFLPFSALMA
The following text describes a protein:
Function:
Required for the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. May play a role in anchoring the cytoskeleton to the plasma membrane.
Subcellular Localization:
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
Sequence:
MTTTITAKIAQRQQQHQQHQQQQLQHQQQQQQQQQHQPTSSMNGFRITGYPAAATPPARSNPIYAKPNAHELDLHISESLLYPGSTTQQQQALQSSPGPPPQLTSMLPSSGLPGAAQPIALKGNNPFLNSPSPTEAAPGVPTGLSSAQPATSASSGNYEMPEYAEPSRLRGLKQRPHSIAVGGSPAQSSFVDYNAQQQQRLLQLSRQQQQLRNAVTAAASTANGGDKETLYAALFQQYRQSPTNGQPAPPVPLHRKPAAAPVVPRRSQSTPRPPLQQQQQQQQAGINGQINGNGNQRPRSLDRFNGGLQSEAPPIPLRRFPNGNGNNNNGTLSRQKSPKKSSSADNMLMSPAGSQVNTMRHSISFHGGQETENGSKAEQTRPMSYAAPAPDQAYLEHQLRAYSEQLRTITESVRKYSEQAKLLSELKRQQQLAKQSQTNLNLLTPTTCNNSTGSNGNNNFQPNMISPEIVSKSLASLSTSQANEAQTPSNQLRLFLDNIRSSMRQEYQQHMPDDVLKPTSTLKRNGTDSLVTSNTAAKPEVEATPTPSDQLRQFLDAIRANKIPESVDKPKMTSSQTLDSFISKPLQMPDVTSGTPGGGVVGGQAASGGVAVNGQTNGIPTRRRPKSSIIPSSSNGKLEQREHSLVTSESFHQISDNLRLMSEDLQALSPSKAIPSSASSNSLKSLAANGGSSLTTELRVITSSPYSTSPKLQQMVMSKSNSSLGSVTTPSSATTTPSTAPMITDFNEILDSFQAMADKYKSKGSYDYLRKCSEALRQHSLQLKLQQQHQAHQQQQLPAHQQQQHQQQQQQQIQNGFASDDNSSSCSTTPGSIREAVQNLLLQPRNGFQILDDRMRLFIDIIDSQDRLSQDLQSEIETHRVVYDRLDGTGRKLLGSLTSQEDAVMLQRRLDEMNQRWNNLKSKSIAIRNRLESNSEHWNALLLSLRELTEWVIRKDTELSTLGLGPVRGDAVSLQKQLDDHKAFRRQLEDKRPIVESNLTSGRQYIANEAAVSDTSDTEANHDSDSRYMSAEEQSRELTRSIRREVGKLSEQWNNLIDRSDNWKHRLDEYMTKMRQFQKILEDLSSRVALAEQTKTSWLPPSSVGEANEQMQQLQRLRDKMTTASALLDDCNEQQSFFTANQVLVPTPCLSKLEDLNTRMKLLQIAMDERQKVLCQAGAQQTHENGDDGRTTSNSGTIGPLPNLGQSVKPPWERATTAANVPYYIDHERETTHWDHPEMIELMKGLADLNEIRFSAYRTAMKLRSVQKRLALDRISMSTACESFDRHGLRAQNDKLIDIPDMTTVLHSLYVTIDKIDLTLMLDLAINWILNVYDSQRTGQIRVLSFKVGLVLLCKGHLEEKYRYLFRLVADTDRRADQRRLGLLLHDCIQVPRQLGEVAAFGGSNIEPSVRSCLEQAGISQEAIDGNQDISIELQHFLGWLQHEPQSLVWLPVLHRLAAAEAAKHQAKCNICKEYPIVGFRYRCLKCFNFDMCQKCFFFGRNAKNHKLTHPMHEYCTTTTSTEDVRDFTRALKNKFKSRKYFKKHPRVGYLPVQSVLEGDALESPAPSPQHTTHQLQNDMHSRLEMYASRLAQVEYGGTGSNSTPDSDDEHQLIAQYCQALPGTSNGSAPKSPVQVMAAMDAEQREELEAIIRDLEEENANLQAEYQQLCSKEQSGMPEDSNGMQHSSSSMTGLSGQGEQGQDMMAEAKLLRQHKGRLEARMQILEDHNRQLEAQLQRLRQLLDEPNGGGSSATSSGLPSAPGSALNSKPNTLQTRSVTASQLNTDSPAKMNQQNGHYEHNSKNSSGLVTVITEQELESINDDLEDSSSSNTTNTTTTTTTTATTEKTCVELQK
The following text describes a protein:
Function:
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses.
Sequence:
MRIPRAAMEAFKFSALISWRSTGKQQQTIARCIEKTGRALHSGDLSTVRIWPELAGTGSVRTVEHLLSALEGTGVDNCRIEIMNSGSDDTSVEVPIFDGSAREWVEAIDQVGLTDAMDCNGRSCDRVAPYLTQPVHVSKGDSVIAAFPANETNISYGIDFPQVSDLSLKWYSSSFCTGSFYSKQIAPSRTFCIYEEVEKMRSAGLIKGGSAENAVAFSISKGLLNPPLRSLEEPCRHKVLDFIGDVSLFARRGSQGLPVANIIAFKGGHSLHAEFVRKLSSTS
The following text describes a protein:
Function:
Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
Sequence:
MSLIPLPESLIPFLDPYLPNIKVTTTNNGSLKRPFVTLTYAQSLDSKIAAQPGTQTKLSHLETKTMTHYLRSKHDAILVGIGTILADDPKLNCRYIFESVKPNEQMISHQIRPVVIDPHGKWQYHQSQLCQICQPSTTTTTTTKKKKKNSESSPVSVPVPAGLAPFIIIDESTIPNIESEKMVIKQGGKYIKLPLLLSTTTKTKISDNWREILQKLYQLGLKSIMIEGGAKIINDLLSINNSTDDDDDDDGQKLIDSVIITIAPVFLGCNGVTVHPYHNVLLKDINWWTGIQDSIIAARIDYHQ
The following text describes a protein:
Function:
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline, the final step in proline biosynthesis.
Miscellaneous:
MISCELLANEOUS: Present with 43500 molecules/cell in log phase SD medium.
Sequence:
MTYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGKLLISLAAGWTIDQLSQYTSTVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNMDAATALVGSGPAFVLLMLESLMESGLKLGIPLQESKECAMKVLEGTVKMVEKSGAHPSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQKKK
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MSIYSRSVSLVRCYSSAQTAMKKPFQGPLFLNPHAWKGLPADQVFELHKIRKEYMGDAYNPTDEERTAILSTISSLVPNKPPLDYAFEIENFKERLMNNTPMQDRGKPQKLSNQYVINSGAVPHQRRRIEQLTRKIAYEAPLLAKYRQPYTPRPRTEAPIRLTYNSDFTDDTSSAHNRKVALKVSLRDLNLNPKQQHKFKVLAGDKFNHDEDTFQLKSERYPEAAQNVNWLVDTFNKLLTEAKDLSKDDYSDIPLSKSHMKILAKKAVPSFPEHWKKPEDAPIKRHDIVKKLVAATEKAKDNEYIRKISP
The following text describes a protein:
Function:
Could be a S-adenosyl-L-methionine-dependent methyltransferase.
Sequence:
MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRKSGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFPEPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAIDKARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.
Sequence:
MQSPAMSMVTPIFPIPLKTNSSKKNFYTTFLTPHKLTLCLLIELYAHRIIQPQHCVPFLDLVLGYFNPNDSQPQTLTRIHDITSHLPSSIEEYSVYSLLHERLWSLHSFEDIHEIFISLGNYIEGVYDSEEEAPHMLFSSSSLLSIFLRKCVVEYEQFSFEQGVQFFKSFLQYRAPSMDFQHEGIEFCKINVRHELMNLASNKTLLQLAFGSIPVSRSSRDIEQLTQVQIEHMQKFGCALPLEMKEKLHDLLEVEENNLNTSYYCKFLNSWFSGDYQQSVENLCRYFDHIMHSDEKVSYQYALLNLAMLQADFGCNEEALHAIEDTINTARESGDTACLNFALAWMFEFKRSQYSNPSPEKNENDDQILEHLARNSQKAQLPILQTTVHLLQVQKFLDDGSSLIGVFSNLTKAFALFCANESFDGFPRYMDLLQSIWYRLGCSILSMTYISIYQKNHVHDSPALDLLQSLITKAWRYAELGRWLDVATILSTAEVQSQRSFQCAHLYGREKTFIYLSKAIDEKNHMDATLYLKNLNGFRHDKMSTFRTQLYALRLDISLGNLSQAIEGIDKLLEEPEKLAIEWVLQLMFLKVDIYMRTEMSNRAVFELLEIIQMASSNYLRLYLLRGLCTLCLIGELDCFTAIDLLDSLIPDIIAADNKPLLALAFHAFASLQIKHLDLLQPSRMFVIQLLDSAIDGYRACYMVEMQKTVVRLKIQYLRQINDPALQPNIEQYCSRFYSDNLLN
The following text describes a protein:
Function:
Required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Enriched at the cell equator during mitosis.
Sequence:
MEPKQRVVKPLKERVLPVVKNTQFVWFSGQVIVLISSVLYALQAIPFRSAPPFLFKSAAFGAIVAYAIVLYKTYSPNLTSRASWNKHFFARLMLDDNVQYFILALSMLIDRPILFSLAPYAIYATFHISTYLRSVLLPAIYPNISDAKTASYASRVSNLLNQYTRSQFQPAMQLVASLETFLLFRLFFGVFLRKNSISRLVGYIFFLRMRYTNSHFTRASIKAVSLRMDRLVADNRVPPVIKNAWHTFKTYVSKFGASPVGTAQSRPTASSSTTAPSST
The following text describes a protein:
Function:
Could play a role in neuronal development.
Subcellular Localization:
Nucleus.
Sequence:
ERGGGGGGGQGQSWGLSGLRAQTCPSPLPWPPAQAHVGLHPCSPAVPWLPPWRGAKVPGVSEPWARICTLLPAPLRPDLQRQRRAPQAGAGYWRGGGGGGGGGGGGGEVCAQSLPPPAAGSGGAARGAPAVTSAGCGAVCKAHWLAWPGHAFPGAEQNGRGPGAPSLRFRERCLRPRRQQPVVCKKNLDSTTVAVHGEEIYCKSCYGKKYGPKGYGYGQGAGTLSMDKGESLGIKHEETLGHRPTTNPNASKFAQKIGGSERCPRCSQAVYAAEKVIGAGKSWHKSCFRCAKCGKGLESTTLADKDGEIYCKGCYAKNFGPKGFGFGQGAGALVHSE
The following text describes a protein:
Function:
Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
Subcellular Localization:
Mitochondrion intermembrane space. Cytoplasm.
Sequence:
MPGLAAASPAPSDSQEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALGFKI
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MFTGDFTQKKKVDLGGRRKELDRGRLLEQAKADRERRAREKLERVSATKIQAFARGRRSVSASRDQSRNSWQGQFGALGELATREALLYDSPFLPQLLFFFRLNNPTDIVRLAAACRLLLQNYSAKEPTALFFANGEAQKQLIMAQRAAKLAVTCLQAVHHNRQALLSELSSPWQASPGSLGNILLQTVLTLSGDFPWARQVLETLARADLFVYIRDILVLVGGSSKAVSSIERAALLLTSRYFEDRVGDLEGSLPARLRFAAQLVSIPFFWQRFSTFKQAAASRGLWQRSVHSLGGILPALGGALPGSPGPALPSEACLLGNLLEGAPGGLTAPQTSTEVASEFIRVGQTLMEGVPSTSYSHKAADVDGMDVESSVESAPGPSLDPALVKQLANLGDVAVLKPLVAALLSVPTDPAQPLQPPTPSEASLVGSLAWFLHSVHTLFPPLRARLFTSLAFSAQFTQRMWLYLKRCHLARQWPSMAVVGWEKQLLPEWLGWMLPLAVFCPVYSYLLMTIDDDEFYEKQRPLPLADLTILLSILKEAVWQLLWTYNSKLGSGSPLATPSDAGLFSAAATPPASTPSATASSHADLSPQAFLKHVGTVAATLLAQLNDRNARREFTQPESFHAKGIVDERFYIQARDDPDSQARELLRKAPFLVPFPARVRVYQSLLDVARSKVANWQTPWTAAEIPIRRNHIVEDGFDHLSGRPGESMRGRMRIHFINEFGEHEAGVDGGGLFKDCMEGIIKVAFDVQYGLFKETADHHLYPNPASHLVMTNGDHLRYYEFLGKILGKAMFEGILADIPFATFFLSKLQSKNNLLNDLPSLDPELYKSLIFLKHYEGDVVDLGLFFSVENNELGEMAETELIPGGKDIPVSNENKIKYIYLVANQRLNLQIRRQSAAFQEGFAQVIDPEWIQFFNEQELRILISGSKESADMDDLRENAVYGGGYDDKHPVIQAFWDVVKSLDSRQQRLFLKFVTGCSRGPLMGFKYLQPQFAIHRAAPSDQPDASVRADIVNRLPTSATCMNLLKLPPYRNKDMMKQKLLYAITAGAGFDLS
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription; E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSKKFKSQASSSRAAAGAYGSFGGFSSAFSSAGRAPSSLTYVTAPPDLSRIADAKLAISFKNFLKKDEVTRIKALDEIKDYVLTVESRDATLDDGFLDAWIKIYPRASIDLSRRVRQTAHSAQGSIASVVGKRIAPYLPKVIGAWLAGFYDNDRPVHRAALESFMLVFTTEEKRNGVWKVYQSSILDFVDDVILQQTPQTLSDERTVKPDDAEAKYARVVGTALLLLNRVIANSTHEDLQKDLATVENLLNSKSMWSLCFHADPFVRKSVYVLLRSAVAKEPEELDWRIISAALIGKSLSINQMGSASDLSECLLEVTSARPQLWAEDYSGKTTSSKRLLQYIQKGSQGGVASFWSNLRQLLQIIPVEVLAKTDPQASTCRMIGLSSATLLTEAFQLGVNSREEPRQNQALGWKSYIETGIWLTSSLPDSDRDAFLHTRLSPLVTQYVRAEQNAPQWTLPNQNAVALCTEYSVALANGNYGSEFQRLWTDLADGLLKSVKLSAPEQSKEFRSSQDAVCAQAERLFALEASVLASVADSEARASVSNILSKTNLPLLDNCLQVLRSRNGKPYAAAAVVEEMIRNAADIAQQSRELADFVQNDAPELLSSPSADRLVSVILSCRSWDGFGSSFDTVVERVAESEPEQSNTHAVQKLLSTLDFKEVHDKTGLDSLIKRALDQACRGSRFHWPIVIAALQNQTSHGELTDSIFLIIVDSLSEPTKVFEALHGLSQIAKSVPDALSKFQAGAHGSKLAGRLLFLAETSDEEVASLAESVLTEFKEIGVVETSAKSSFELLQYNFDHVNEESLSIGSLLSIAEDLLGAADPEARASIAKDILPSRQTWETALRPFLELPPRPSTAITSPLGGTVHLVNPEISDTLKEQYHTIPRDSSGCSSAFRLAYFTIRVLSSFDIMGNLSAEEQETLFHYIPLAVQLIDDDLSIENCNGITGLTHSDQREEYLEIVYDGRKVMNQWTGSDGRQSEANATVALRTLSFWQNKLEALNNTSPTDYRIGEAFVRLMNSLDSANKSKSTEDITNICREMRSANAIRSASWVAVLRESILGNPTGNRLCNELVADSTGLKPQDEKKEGRLPIGSSLGDSTDALQGLRKLSLLNLLLAGEINVASTIPTQRLVFLVKHLIQCLQSKDLPLNIQAEIMHTLTFVLPCLNEIYGSHWEDCMEALSTVWRETSGGDEALPLLLGSFRLFASLRSIVAEEDSNDDVKDAWSERKTVLFNGLASTLTKFDYTIAFHQPRDVTVEVLCRLIKVMPVESLEDASRIYHLLTADSRVIQRAAFTLLHRYIPSVQEQVSFDVALSKSVVRLPDELMSLLLEAPTMESITLADGDDKIWTSIRSYLLSWKVVFDHFVNASLPVQEQYVASIKDSDSLGPLLEFMFDFLQQPNNKLVDASKFDIRSFEPDQSETQEKETQWLLVHLYFLCLKHLGNMTKNWWLDTKKRIKGPVEAWTERFISPLIIEDSLKGVDEWMTTQDPNEERALSVKISPKTAEIIASIPVDEESPPVALSISLPPAYPLQPALVVGRSRVLVDERKWKSWLLTIQGVIMFSNGNLVDGLMAFRKNVQGALKGQSECAICYSVISTDMQTPNKRCATCKNTFHSVCLFRWFKSSNQSTCPLCRNNFVYV
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Regulates protein levels of sulfur metabolism enzymes. The SCF(SKP2) complex may regulate some transcription factors or regulators of cysteine and methionine biosynthesis.
Miscellaneous:
MISCELLANEOUS: Present with 432 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MKRLQLFGRSKYFSLVSSAAKEEEEEEEGCADAKSLLHSTSHDIKSRSLRFNDKSSLMCLPTKVLLLILRTLDFNTLVTLCQVNSRFYNLITNEFLFQNVILDSKLSLLKFNALIHSEFHTSNIVTHSGDCSTQSRSQNARFLVRSIEFKNPQSQDSLLKYSKFYNKSGQDSIIAGSYKLDSYDKDVKKLNNIRLNDETPIITSERIKLLDKLESNYFHYTYIELMLDIIDYLPNLTRVILSDVEPNFKIPLWYSVFNDGSRDFFKKIIKGQQSITNEDLRTFQLSKKFVKEYESKYYSLPRLKILEIKANNKRQRTFNRQRHHQKLVLRPSLFCCFGIINELKLENVTIDTESLDTPMEFLPLFLKNEDNELYSLQSPITALTLDSCDVVPGNGILRLFHSYFKMVKHLSLLKINSKFDLLLCSCFPSLSNLTIDCNSKCFTNEQVVGESYYFQQRSLDTEDDFDDCNSMTETLFEAPSDSKIITPPPTSSVVLSLNLNYISRTTGNDVSNNPSPDNNKKPAMLTAAQLQNFQRQRIPEFHSFYHYYRLLWERLPSKNISINVINIPFTNVYPLSPLSFWEHLARTITSVDETDEDVGDENDQETLIGYENNSIRDNIPNANAVPNLSTVMSPESDIHHTYYWNNSVRRCLRDSLIKLKNRTIEYRDLDVEEFLQNVTLENFFNDFQDPENFKDIPNINLWCFLRNLSKFKAVKIRMLRHFSLCTPRTRYDWELLLKPVLRVNVPIEVRDKDGFVLYSYGQK
The following text describes a protein:
Function:
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEHAIVWDLSLIQKYNYSGPRYTSYPTALEFSEDYNESAFQQAVKRYPQRPLSLYVHIPFCHKLCYFCGCNKLVTRQQHKADEYLVVLEKEIRQRAALFTGRQVSQMHWGGGTPTYLNKTQISHLMTVLREHFDFLPDAEQSIEVDPREIELDVLDHLRAEGFNRLSMGVQDFNKEVQRLVNREQDEDFIFALIARAKALGFNSTNIDLIYGLPKQTPESFAFTLKRVAELNPDRLSVFNYAHLPSLFAAQRKIKDADLPTAEQRLDILQHTIRFLTESGYQFIGMDHFARPDDELAIAQQEGTLHRNFQGYTTQGESDLLGLGVSAISMLGDSYAQNEKDLETYYACVEQRGNALWRGLTMTEDDCLRRDVIKTLICHFQLSYQPIEQRYGIRFADYFAEDFELLAPFEQDGLVERNETGLRVTPRGRLLIRNICMCFDIYLRKQARKQQFSRVI
The following text describes a protein:
Function:
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
Subcellular Localization:
Nucleus.
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
The following text describes a protein:
Function:
Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MASALCPPRGPKLKGAPPSHYYENFLEKKGPCDQDYRKFWAGLQGLAICFYNSNRDLQPLEKLDLRLFSKLKDEALLGSSHDTTYHFSLVLRDQEVKFKVESLESCEMWKGFILTVVELRVPSNLTLLPGHMYMMAEVLAKEEVRRAAEVPWCFLQVSRLEAQLLLERYPECGNLLLRPGGDGKDSVSVTTRQILNGSPVIKHYKVKREGSKYVIDVEDPFSCPSLEAVVNYFVTHTKRALVPFLLDEDYEKVLGFVDSDRENGENAWTVPSSRGSGPALPANVPKPLPPVPVSVSSQEDKLPQLPPLPQLPDQDENYVTPIEDSLATEYMNRDDLKAITNIWTRKLGGSSPQASSLVTRLGDITAELEEKLQKRRALEH
The following text describes a protein:
Function:
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDWMRLIRDLCFNPRHTKWMAPLLVLGDAFLCALIIWKVPCKATAKLRSHPFATRERDYTLIRGSTGPLVYPAAHVYSYTALYHLTDEGRDIFFGQILFAVLYLITLVVVLCCYRQSGAPPYLLPLLVLSKRLHSVYVLRLFNDGLAALAMWVAILLFMNRKWTAAVAVWSTGVAIKMTLLLLAPAIAVVTVLSLSLGPSVGLGVLAVLVQVLLAIPFLQNNPAGYLSRAFELTRQFMFKWTVNWRFVGEEVFLSKSFSLALLAVHIVLLGAFAVTGWLRYSRSSLPAFIRNLLAGRHRTVSLPKPYIMSVMLSSLTVGLLCARSLHYQFFAYLSWATPFLLWRAGFHPILLYLIWAMQEWAWNTFPSTNLSSIIVVLSLATQSFGVLANSASAFYTMRSNPSGKEHNQ
The following text describes a protein:
Function:
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Subcellular Localization:
Cytoplasm.
Sequence:
MIKPMVRGGFYFLYEALHGPPRNILVEDANVALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVCEVYGVVKAYTTRVGIGAFPTEQNNEIGELKSRCGWLDLVLLKYAHMINGFTALALTKLDILDMSTEIKVAVAYKLDGEIIPNSPANLEVLNKVEVQYKTLPGWNTDISNARTFKDLPVNAQNYVWFIQNELQIPVKWIGAGRSRELMFNSFKDCQCKKEAHSLCPLAPLTPQKKERTKERKKDKDCLFVKHFIFNVQSQCYGH
The following text describes a protein:
Function:
Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells. Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK. In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation. Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFGSLPSKAEVLNWDSHSLADFLKKRNLTGCDNVVKRFNINGQRFLNMSENDLRRFPQLHAPFISKICQEICKEKKRLFGMRPSQPVPSYPQPAAEQREEQAWDSEEFTSDEDDYENPDSNNDDDASGGDYESPAEGSDSDNSYEPPPSEPSEDKAQICPAKPMDNCDYIDNNRTRVVNRSQPPVPPERPGPGPSVPPVDRPSVSPSYFQTVGMHERMREERPQTPKRPAAPAVDRSKKPGTLDRIHPPAVAGGRGTSSLDRAINPPRSVNAAPFRGPAMEAPGDPMRIPKPSLPPSLGVRRSASSVTPGYSQNRHLDQRHEFHDDTARQTSNTFPLHARNPSPRPPGTHGQSFQTDSVNPSRSLPAKLQEAMTDHRRSARASPPQTDMGGRQDMDPAWYLGQITRGEAESCLRRVNRDGTFLVRDSSNRSSNQPYTLVVLYQDKVYNIQIRRNQDRFMLGTGMKASESFERVSDIVNQHKHTPLLLIDAKNRESGQQKQCALIYPAGY
The following text describes a protein:
Function:
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MTQLQTANSSKQEQQQQHQNNQPADLSSIYRSLQQELLTNKQVVEENIPNPLSLIALITHTILRSHSFTIKNSSDNQLQSILILNNQTHSSLLSYSHPRSSLSFEFTLSKIGNRISIAGIAVEDDRLSTLDLSISEYLDPAEFPLTLTKEHQTSSIGLRSTTHLLDFLSLFVNKILNHLLPDLIPPTSPNHRPPPPASSSTSTSQPSQPAPERFESPQMNLQSSHHRSPLEIGRSDLDPIGTSNLHIPSLYNAPSGGEGLLGGHSGMLVGGNHPIFNRQHQAPGRIGGGGGLPGASLPPGAVPPGARFDPFGPAFPATQPGFGPDFDPMGGLGQGLPLQNPHHGFSSARPDFNNFRPSGGQGGSGYDDMFM
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGALAELAGDEKNGEGSRTFVFTNEGHTLGNALKTIIARYPEVDFCGYTIPHPTEQKLHFRIQSRRDRAIDILKRGLEDLEGLCDHTIVTFEKEMAEFNAMKVEN
The following text describes a protein:
Function:
Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
FhuD interacts with a periplasmic and a transmembrane/cytoplasmic region of FhuB. The transmembrane region may be part of a pore through which a portion of FhuD inserts into the cytoplasmic membrane during transport.
Sequence:
MSKRIALFPALLLALLVIVATALTWMNFSQALPRSQWAQAAWSPDIDVIEQMIFHYSLLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGAMASQFAAQAGACVVGLIVFGVAWGKRLSPVTLILAGLVVSLYCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWGGVERLWPQLLGGVMLTLLLLRPLTLMGLDDGVARNLGLALSLARLAALSLAIVISALLVNAVGIIGFIGLFAPLLAKMLGARRLLPRLMLASLIGALILWLSDQIILWLTRVWMEVSTGSVTALIGAPLLLWLLPRLRSISAPDMKVNDRVAAERQHVLAFALAGGVLLLMAVVVALSFGRDAHGWTWASGALLEDLMPWRWPRIMAALFAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGSLGAAVTLLIIMIAAGRGGFSPHRMLLAGMALSTAFTMLLMMLQASGDPRMAQVLTWISGSTYNATDAQVWRTGIVMVILLAITPLCRRWLTILPLGGDTARAVGMALTPTRIALLLLAACLTATATMTIGPLSFVGLMAPHIARMMGFRRTMPHIVISALVGGLLLVFADWCGRMVLFPFQIPAGLLSTFIGAPYFIYLLRKQSR