lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MVLVCSAYNCKNTLRNKSVSFHLFPLKDSSLLKKWLKNLRWKDWKPNPNSKICSAHFEEKCFILEGKKTRLHTWAVPTIFSFPNRYSERNVKINPRSRRARRIVGDPSSSIQAAETSDESNSVNPAQRSTDTSSHTNTSEANSSDLTGAKPNGDSTQQLTEPEKSLQWTILGDEVLDRSMTIPSFFHSGYCFPNNIRWAGDDELNIVPHVVYGVLGQTKPQIIEVKARWEWLGLDVRGPFSPTVNKHTHIMTLTDYHSKWVEAFPLTESLSQDVAQCLAEVIRQQGYPLGVLSRLPKRILLEINRELKKHLRLNANALVIHHRQTGYMDLVTESLLNDMLDELVKKHSGIWHIHLPAAMLRLCCTNHPTTKEKPFTRMCASDSPFSSSPRELPFSATDIRLSSFVIPTTKQTI
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MGEHNLLNPGFVGPLVNIHTGDTFYFPNFRASGAQLPGLPSLPYPRRDNVCSLPWASGEPCNAYPQPYLGGPVSLSPPFGRTCELARVDDTKCYYRDACSEPGAGLKREERGRDTGLMTLEPSGAAAPAMAFAGGKYDYSAAAAAAVGPGVDGSAPHDPASCQSLESDSGSSLLNEGGKGGGGGGGGGGDAGALGSPINQGHGLSASGTPWYPLHTRSRKKRKPYSKLQLAELEGEFLVNEFITRQRRRELSDRLNLSDQQVKIWFQNRRMKKKRLLLREQALSFF
The following text describes a protein:
Function:
Plant-specific microtubule-associated protein (MAP) that regulates the orientation of cortical microtubules and the direction of organ growth. Determines microtubule organization by modulating microtubule severing.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Bound to microtubules.
Sequence:
MSTPTTSGSAAKPTRPARSSSLATRSCSNSGSLTSFQAMVELKQKILTSISKLADRDTYQIAVEDLEKTIQSLTPETLPMFLNCLYDSCSDPKPAVKKECLHLLSYVCSLHCDSTAAHLTKIIAQIVKRLKDSDSGVRDACRDTIGALSGIYLKGKEEGTNTGSASLAVGLFVKPLFEAMGEQNKVVQSGASMCMARMVESAASPPVTSFQKLCPRICKLLSNSSFLAKASLLPVVSSLSQVGAIAPQSLESLLESIHDCLGSTDWVTRKAAAETLTALASHSSGLIKEKTDSTITVLETCRFDKIKPVRESVTEALQLWKKISGKYVDGASDDSKLSASEQLGSEKNGEKRSNLADLMKKEASDGSTLSPDSASKGKGCFPEKAVGLLKKKAPVLSDKDFNPEFFQRLERRQSVEVVVPRRCKNNDEEESGLDDLNAMGSSNRLKNTQADDKQVKGRFDGNGSQARTSGDDKAGVVNGKETPGHHAPVSNTDNQSEGSFTSNRGNWSAIQRQLLQLERQQTNLMNMLQEFIGGSHDSMVTLEGRVRGLERIVEDMARDLSISSGRRANLTAGFGKYNSFANYPTGKYNGRAPGERGSQTDGAMRGRMWNSDMADDWFIPPHAASRNGQAGPRRSPRSEQYENEHMGNGRRGWDNKASGTIRFGEGPSARSVWQASKDEATLEAIRVAGEDGAVPRPTRVAVAPEAEAMGDDDNEGQERDPIWVSWSNAMHSLRVGDIDAAYAEVLCAGDQHLVIKLMDKTGPSLDQMSNEIANEALNFISQFLLDHSLYDICLSWSQQLLELVLQDGADTFGVPMELKTEILYNLQDACSTMDPPEDWEGPAPEQLVVQLASVWEIDLQQFDK
The following text describes a protein:
Function:
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to urothelial apical membranes (By similarity).
Subcellular Localization:
Membrane; Lipid-anchor. Late endosome.
Sequence:
MTDGDYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYDTQGADGASGKAFKVHLQLWDTAGQERFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCENPDIVLIGNKADLPDQREVNERQARELAEKYGIPYFETSAATGQNVEKSVETLLDLIMKRMEKCVEKTQVPDTVNGGNSGKLDGEKPAEKKCAC
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MPSTADERQLLDELRDLLAATVEDLTVEEIGPDSSLQDDLGVDSLARLELVAAIEDRWQIEVPQEQADRLTTVRQIAAHLAEAVAAPAGGTA
The following text describes a protein:
Function:
Zinc cluster transcription factor involved in resistance to cycloheximide.
Subcellular Localization:
Nucleus.
Sequence:
MDSITVKKPRLRLVCLQCKKIKRKCDKLRPACSRCQQNSLQCEYEERTDLSANVAANDSDGFNSSHKLNFEQQPVLERTGLRYSLQVPEGVVNATLSIWNAEDMLVIVGLVTFLDYPFAAHSLAQHDQYIRALCASLYGMALVDFSNYANGIPCEDTSRSILGPLSFIEKAIFRRIEHSKQFRVQSAALGLLYNAFSMEEENFSTLLPSLIAEVEDVLMQKKDCEILLRCFYQNIYPFYPFMDISLFESDLTSLLLQDDNNRWKISTEVKNVRKKIETLSLLTIVMAMALMHSKLDANLLSMVKENASESARKLSLLCHKLLCLLDVFRYPNENTFTCLLYFYVSEHLDPESPDCVLSPTNLLTLHHLLNLSMTLGLQYEPSKYKRFKDPEVIRQRRILWLGVQSLLFQISLAEGDAGKSNSEYMEAYLTDFEEYIEASSEYEKSSASESNVQMNDIVWNKYKFHVILSKLMSDCTSVIQHPQLFHILGNIKRSEDFMAENFPTSSIYQPLHEKEPNAIKVGKSTVLDVMDIQKTEIFLTNIVGSMCFLNIFDVLSLHFEKKCVMHWEEYEKNYHFLTLKSFNAYLKLAGLISDYLENKFQGNILESRGYIIDKQICFMLVRIWMFQCRILLRFSYKQESQKKLASSSISTNDNEKEDEMIVILERLIKHIRNQMAHLVDLAKGKLQDSYFGAYQTVPMFRYVVYLIDVGGLVSVTNGFWDKISSDGEIPPKVQQAVRLKWGLDCNNSRRIKQKLISSQSLQSFNQVLLCQMEDAVLSSSFAIKANTAMSQNTAEEFFNISEEEALNQLLENNNFDAFWDLLGENLSDMPSL
The following text describes a protein:
Function:
Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle.
Sequence:
MADPDAIYELAQRIESNIEVDKRVAALHSLQSLLESAGHVVEADAVTSAVKVALRHANQALSTASLSFIPTYASMIYSGDATDSHSLLNHNVRMLVNSVGLLVIDKLGDQKERIREAARTALIELGNAAYAISSGHLTTSGKGKETETPLGIFERTLREAGLAAKFARVREQSVLLLPILRQSCEKYPIRPLLSTTVELLLDADATVREGARSTLITLFSSATPAAKADLKKELEKRAVRKQTADAILREVLGAPSAATSAPVLSPPAPTTFAPTTRSQFNSSHGADASIPTSYMKSAPAAGTTFPSMPSASATAAADGIRPVYIASRSDLERTFTTMMPFFENKESEHNWLNREQSMIKIRGLLVSGAHRQFGETLFVAQLKAVQEGILKCISSLRTTLSMHAIHLVQELAMELGDDLAPCVEAFLIHLVGMAGFTKKLIANATQEAAAAIMVNVSFRPLYLQLIWQAFQEKNVATRTAAAEHLCTVLNTHAAHRKHAVESHGGLDLLEKCMRKGVGDSNPAARTKSREAFWIFHRHWAAQANALLNSLDPAIRKQVAALAPSDVETDTIVEQQPKADGGPVRVRPGGASMALIQAKKAAALKAAQERDRKKAEDAAAAHEARVAAARAALAEQQQQQQQVQKHLEQQASVEDFVTPVAANNKKGTGFMPIKNRSLHHPGGQGAGAANLKPATELTVVISPTAHQRIQTAISVPLPTSPTPAVTPNARIKSKNLSQTSWETPPHPRSPGLSPVSARSRAISSSSYSSQGSSSSARMQGAASTPRSNRAPPVTHSTLKADLENLSIDGIDGIDDGEVTADATQQARFATSSRDNGTGEDDTLQMNAPEDASMDLMGMDFNSPFKMPASGGRAVKTQSVLLERQNALDALQQTPQPKSHRTISTSSTSSTNSSTTPASASVRRSGLPRPVSTMHSPSPSASASHISAGHIHAPTTSHRVLSSTPSRRAPTNGVSTALENRAKRLDAQASTASASPAKAKPEVWTWIQALMDGTADLRTFRRLARLSSEFGISATKAADERTEQDDEMVLERGPFSNVAWATKSDGAFSSGLQAWLEGGLFGKLFDGLKRYLCVGDGGGSGELQMSAQVVLLRLVENQFSLFGATDREGELLDVVLQSITLLCGTRTSCVASSSIVAGRAALQGFESILGAWSGRCDPVLGFDALLSRSLSDASTVAVLRSGFTPLLVRLPAQLVLEDFLPRLAPLLTSTLHHASPEKRLTAVTVLRHLNDMVRIDAQDSHTRIFDALGLTIRDDDDQAELKSKRALLDVLMYYFSKN
The following text describes a protein:
Function:
Acts as a non-catalytic accessory component of a dynein complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSCPIDSKKLEEICLEAAQPVLKASEYDGDKTAEMNQSVIYAVLNALNKETQSYKWIVSSTLVQKLPEDHPSRGVHAAHAACWNCEKDGMTTIKESGEAIDVVLSIMWISI
The following text describes a protein:
Function:
Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.
Sequence:
MSKVGKGLLAAAETLKKYPVDVQKALLRSATDSARSQNIEEKAESCNLTPRELHEAVEAASCMLASFSRLKEAAMSTTLQQLFLDRGVADVLKELLQSKGSSSSEFSPYGKLVDVRWKIGVAAVSDQCKNLNSPFVTFQLTVEDSQNRMDTHILELTIPEFQKFASTMQELHGIMSTL
The following text describes a protein:
Function:
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
Subcellular Localization:
Cytoplasm.
Sequence:
MELNSEDVLVARYGELVLKGKNRSYFTKQLKINIKKAFKKLEINNSIVYEFDRIVVFDIKKEQRAILQELFSFLPGISLFFFASQIVREENKLLDLLFNLFKDFNSFKLEVKRRDKNFAENSSNFKKYLAVKLFEKYQLKGVINNPEIIANIEILKEHFLVFTERFKGKGGLPVYSSGKALVLLSGGIDSPVAASLVMQRGFNIDFITFINEPNKNQKTIEKITRLANLISFNKTICSGKLLVFDFTAIQKELIHISNESYRIVLMRRVFYKAASMFKYDCLVTGEVLGQVASQTIENLKVIQSATPDTFIVRPLIGFSKDKIIELAKFFNTFDISIEQHLDTCSEFSPKNPTTKAKLINVEKLESELIFLNDLIEKGVSELSND
The following text describes a protein:
Function:
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
Sequence:
MAEAVWSTDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAQMGKDLIDLATFRPPQAASGHRPDEEEEEEVVIGWQEKLFSQFEVDLYQNESACQSPLDHQYRQEILKLENSGGRKNRRIFTYTDSDRYTDLEEYCQKITTSASEVPSFLAERMANVRRRRQDRRGVEGSKLKSRIVTWEPSEDFIKNNHAINTPLQTMYIMADLGPYGKLGYKVHEHVLCILKVDSNGVITVKPDFTGIKGPYRIETEGEKQEHTSAWKYTIDNVSSLAQPEEEEREQRVFKDLYGRHKEYLSSLVGTDFEMIAPGALRLFVNGEVVSAQGYEYDNLYVHFFVELPAANWSSPPFQQLSGVTQACATKSLGMDKVAYFSFPFTFEAFFLHEDESAESLPEWPVLYCKVLSLDFWQRYRVEGYGAVVLPATPGSHTLTVSTWRPMELGLVAELRRFFIGGSLELEDPSYVRIPGTFKGERLSRFGFRTETTGTVTFRLHCLQQSRAFMESNSLQKQMRSVLDRLEGFSQQSSTHNVLEAFRRARRRMQEARESLPQDLVSPTGTLT
The following text describes a protein:
Function:
Involved in rRNA-processing and ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MRQKRAKAYKKQMSVYVHAFKFREPYQIIVDNELITTCQSASFDINKGFTRTIQAENKPMITQCCIQALYDTKNQPAIDIAKSFERRKCNHREAIDPSQCIESIVNIKGQNKHRYIVASQDLQLRKKLRKIPGVPLIYMNRSVMVMEPISDVSNQYNMNYESKKLTGGLNDIEAGKLEKQNEGEDGDGDESEVKKKKRKGPKEPNPLSVKKKKTDNATAASTNQEQKKKPNRRKRHGKSKAEEKEDQEQEQVNEATTNEDAQEAITATE
The following text describes a protein:
Function:
Converts phytoene into all-trans-neurosporene as the major product, via the intermediary of phytofluene and zeta-carotene, by the introduction of three double bonds. Both intermediates, phytofluene and zeta-carotene, can be used as substrates and converted to neurosporene. 1,2-epoxy phytoene is also a suitable substrate whereas the C30 diapophytoene is not.
Sequence:
MSKNTEGMGRAVVIGAGLGGLAAAMRLGAKGYKVTVVDRLDRPGGRGSSITKGGHRFDLGPTIVTVPDRLRELWADCGRDFDKDVSLVPMEPFYTIDFPDGEKYTAYGDDAKVKAEVARISPGDVEGFRHFMWDAKARYEFGYENLGRKPMSKLWDLIKVLPTFGWLRADRSVYGHAKKMVKDDHLRFALSFHPLFIGGDPFHVTSMYILVSQLEKKFGVHYAIGGVQAIADAMAKVITDQGGEMRLNTEVDEILVSRDGKATGIRLMDGTELPAQVVVSNADAGHTYKRLLRNRDRWRWTDEKLDKKRWSMGLFVWYFGTKGTAKMWKDVGHHTVVVGPRYKEHVQDIFIKGELAEDMSLYVHRPSVTDPTAAPKGDDTFYVLSPVPNLGFDNGVDWSVEAEKYKAKVLKVIEERLLPGVAEKITEEVVFTPETFRDRYLSPLGAGFSLEPRILQSAWFRPHNASEEVDGLYLVGAGTHPGAGVPSVIGSGELVAQMIPDAPKPETPAAAAPKARTPRAKAAQ
The following text describes a protein:
Function:
Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Plays a role in the complex assembly and recruits XcpZ resulting in a stable complex in the inner membrane. Provides thus a link between the energy-providing XcpR protein in the cytoplasm and the rest of the T2SS machinery.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MSGVSALFLPPASTAGADGELAVWWVQDGECRRAPFAQALAEIRAPWRLYLPVEAVTACAVNLPTQKARWLRQSLPFAVEEQLADDVEQMHLALGPALADGRHRVFAVQRTWLAAWLALAEGAGKAPASLHVDADCLPGEGSCLFWLEERWLLGGSGAVRLACGSEDWPVLRDSCPPPQRAFAAQEVAPLEGVEVQALAGNPHVWLSEQPLGTDLAQAEFAARQQSSQWRRWRPLLGLVGLWLVLQWGFTLVQAWQLQREGDRYAAQSAELYRQLFPEDRKLINLRAQFDQHLADSASSGGEGQLLGLLGQAATVIGGEPTVSVEQLDFSAARGDVALQVRAPGFDVLERLRSRLSESGLAVQLGSASRDGSTVSARLVIGG
The following text describes a protein:
Function:
An ATP-dependent DNA helicase which unwinds DNA in a 3'-5' direction. Plays a role in recombination.
Sequence:
MLDSPLLSKIIEKPTALSVLKSVFGYQSFRKGQEEVINAALNGQDALVVMATGNGKSLCYQIPALCFDGLTLVISPLISLMKDQVDQLQANGIEADFLNSSQTLEQQQQVQNKLISGQLKLLYVSPEKVMTNSFFQLISYSKVCFIAIDEAHCISQWGHDFRPEYTQLGGLKASFPDAPIMALTATADYATQQDILRHLNLKNLHKYIGSFDRPNIRYTLEEKYKPMEQLTRFVLAQKGKSGIIYCNSRNKVERIAESLRNKGVSAAAYHAGMETAIRERVQQDFQRDNVQVVVATIAFGMGINKSNVRFVAHFDLPRSIESYYQETGRAGRDDLPAEAVLFYEPADYAWLQKILLEKPETPQRQIEQHKLEAIGEFAESQTCRRLVLLNYFGEHRQTPCNNCDICLDPPKKYDGLVDAQKVMSTIYRVGQCFGAHYVIAVLRGMHNQKIIERQHHKLSVYGIGKDKSKEHWQSVIRQLIHLGFVQQVISELNPTLQLTESAKVILKGEEPLELAMPRISAISKIAHNPQRQGVANYDKDLFARLRFLRKQIADKENIPPYIVFNDATLQEMAQYMPTSNIEMLQINGVGSIKLERFGQPFMALIQEHKAILANAQNND
The following text describes a protein:
Function:
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.
Sequence:
MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEVALELTETDYSQDETFTELPFSRRLQILFDEAEYVASVVHAKVLGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKALRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGKTALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDSTLDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMTILQGLKATYEKHHRVQITDEAVETAVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKAKHVKADDSDLSPADKALMDGKWKQAAQLIAKEEEVPVYKDLVTESDILTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAKALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDDGVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSSDHMQEVVKIMVKPLVASLAEKGIDLKLQASALKLLANQGYDP
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTEQTSEATVVNNSPAPTIPKIKREKPTPEEIEERRKLKQLEVVPEGFSRKQWKRELKKQRWQDTKQEYLEVQREKKRLARQRKRERLKDLDENDELRKAQPIPSRQISTNNVSVIIDCDFDELMHEKEIVSLSNQIKACYSAMRHCTYKLPIQITSFNKRLKQRFEAQLHDYHLWQGNISFTDRSLTEYVTGAPNSESKDNDGNSNSNTTNSTDTINTENLVYLTADTDEEITKLEPNHTYIIGGIVDKNRHKQLCYNKAKELGIKVARLPIGKYIEMNGRHVLVTSHVYELLCKWFENDGDWETAFNKVLPPRKIKSKSPS
The following text describes a protein:
Function:
mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MENSQLCKLFIGGLNVQTSESGLRGHFEAFGTLTDCVVVVNPQTKRSRCFGFVTYSNVEEADAAMAASPHAVDGNTVELKRAVSREDSARPGAHAKVKKLFVGGLKGDVAEGDLIEHFSQFGTVEKAEIIADKQSGKKRGFGFVYFQNHDAADKAAVVKFHPIQGHRVEVKKAVPKEDIHSGGGGGGSRSSRGGRGGRGRGGGRDQNGLSKGGGGGYNSYGGYGGGGGGYNAYGGGGGGGSSYGGSDYGNGFGGFGSYSQHQSSYGPMKSGGGGGGGGSSWGGRSNSGPYRVLGGRSVSSGSTGIVTFWRVFRI
The following text describes a protein:
Function:
Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal region is compact and probably functions to regulate the ATPase activity and the oligomerization. The C-terminal region contains the ATPase activity and the oligomerization domain.
Sequence:
MTDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLNARIAIGGLYGDITYPVTSPLAITMGFAACEAAQGNYADAMEALEAAPVAGSEHLVAWMKAVVYGAAERWTDVIDQVKSAGKWPDKFLAGAAGVAHGVAAANLALFTEAERRLTEANDSPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPKVAAALKDPSYRLKTTTAEQIASRADPWDPGSVVTDNSGRERLLAEAQAELDRQIGLTRVKNQIERYRAATLMARVRAAKGMKVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVIAEPKLVETSRKDFVAEYEGQSAVKTAKTIDQALGGVLFIDEAYALVQERDGRTDPFGQEALDTLLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPEELLEIANVIAAADDSALTAEAAENFLQAAKQLEQRMLRGRRALDVAGNGRYARQLVEASEQCRDMRLAQVLDIDTLDEDRLREINGSDMAEAIAAVHAHLNMRE
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MCHYVTNRTKTCIKKKSTRFCILLKILEPTGIQRRSSHGVVVKLPNPRDKGYQQRCIKKLMEFLIENSYPHQVSTKNLMSPSSNDFIRVFQFIYQFIIPNVAIGKKYEEEVPNIFRSLGYPVTISKSFMFSVGTPHTWPILLQALTWLTEIVQLALLFEIDEIMLLDSDPTSSLAGEVVASDRALQYDYMTTGYNEFLLGKDDYPELQEHLQQELDRRWKSVREKISSIETHIEHQMEELSILENDPLSVDNLQKKQAILIEDRNKFKKYIQDLQLHNSRLVRLEQKQVEEKQTLESETRSLEELSKDLKARISEQKLSASAAEKIKMAIKEKQSLCNVLQKELDEGNEELWNSELKLTKRRDKYEEAYRLYLSHVKKVLPSTSENESIENYELCINKNLISQKRKVVKPKISQVKREFSDKIRRCNSKRVTEEANVEEVLRSLANTQDRYEGLEAEITSIKEKTQAEKVDFRDRKKGLKDKVTDIDNEILQDRNCESKCDRIRREIELLKKEQERVNQEIIISTGDMDREICKVAEVVAKHKSYMKSLADNCSNEVTKIIKKRLNSLTECKEEIDHLVLEQ
The following text describes a protein:
Function:
Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
Subcellular Localization:
Cytoplasm.
Sequence:
MTAKTLASLLNNVAVQRLIGEPLVPVQSLTYDSRRVEPGSLFVAIRGQHSDGHQFIDQAIARGAVAVVVDQRYWDERPVAVPVVVVADSRVALAPLAAAFYDYPGRELTTIGITGTKGKSTTTDVTAQLLAATGRMVGMISTVDFQIGNRRWPNDTRQSTPEAPEVQALLREMVTAGCDTAVIEATSHALSPRWGRLVGCAFAVAVMLNIGHEHLDYHGTFEQYRADKAQLFALLGERSGSRWAIVNADDPNHAYFLDAAPADAVRLRYGLHEPADVQGQILHSGPMSSVVRVTSPWGTTDLTVPLPGRFNASNALAALTVALSQGVALEAAAAALAGVRAPRGRMVPIDAGQPFAVIVDYAHNPDSFEQIFAMLRPQVQGRMIAVFGSAGERDVAKRAIQGEIAGRMCDLLVLTDEDPRGEDREAIIAQIAAGAERAGKRPGSGYLCIPDRAQAIRAAMAAAQPGDLVLLLGKGHEGSIIYADFSLPWNEEREARQALAELGYHRSHD
The following text describes a protein:
Function:
Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid-expressed genes. Specifically recognizes and binds the consensus sequence 5'-GCCARG-3'. Required for virulence in invasive pulmonary aspergillosis (IPA).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Cytoplasmic at acidic ambient pH, and nuclear in its processed form at alkaline ambient pH.
Domain:
Only zinc fingers 2 and 3 contact DNA. Zinc finger 1 interacts with zinc finger 2; Interacting regions A, B and C form intramolecular interactions in the full-length translation product at acidic ambient pH, keeping the protein in a 'closed' conformation preventing proteolytic cleavage by the processing protease.
Sequence:
MLGAMAEEAVAPVAVPTTQEQPTSQPAAAQVTTVTSPSVTATAAAATAAVASPQANGNAASPVAPASSTSRPAEELTCMWQGCSEKLPTPESLYEHVCERHVGRKSTNNLNLTCQWGSCRTTTVKRDHITSHIRVHVPLKPHKCDFCGKAFKRPQDLKKHVKTHADDSVLVRSPEPGSRNPDMMFGGNGKGYAAAHYFEPALNPVPSQGYAHGPPQYYQAHHAPQPSNPSYGNVYYALNTGPEPHQASYESKKRGYDALNEFFGDLKRRQFDPNSYAAVGQRLLSLQNLSLPVLTAAPLPEYQAMPAPVAVASGPYGGGPHPAPAYHLPPMSNVRTKNDLINIDQFLQQMQDTIYENDDNVAAAGVAQPGAHYIHNGISYRTTHSPPTQLPSAHATTQTTAGPIISNTSAHSPSSSTPALTPPSSAQSYTSGRSPISLPSAHRVSPPHESGSSMYPRLPSATDGMTSGYTAASSAAPPSTLGGIFDNDERRRYTGGTLQRARPASRAASESMDLSSDDKESGERTPKQISASLIDPALHSGSPGEDDVTRTAKAATEVAERSDVQSEWVEKVRLIEYLRNYIANRLERGEFSDDSEQEQDQEQEQDQEQEQDQEQGQDRVSRSPVSKADVDMEGVERDSLPRSPRTVPIKTDGESAEDSVMYPTLRGLDEDGDSKMPS
The following text describes a protein:
Function:
Involved in formation and maintenance of cell shape.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Note=Colocalizes with penicillin-binding protein PBP2 throughout the cell cycle. In newly formed and elongating cells, the foci form bands across the cell, which are predominately located at or near midcell. In cells undergoing septation, the foci are not observed at the site of septation but are positioned close to the midcell of the nascent or forming daughter cells.
Sequence:
MARDRTRPEDFTRPLRRILVGGLVLLLLGIFLIWRIDSPRVEQFRAALIDRVVPSFEWLMTPMTKVAGMVENFQSYTRIYEQNQELRRELQQMKAWKEAALQLEQKNARLLDLNQVRLDPKLTHVTGVVLADSGSPFRQSVLLNVGARDGIRDGWATMDGIGLVGRISGVGRTTSRVILLTDTSSRIPVTVQPSGQRALLTGDNSPSPPLEFLDKPDLVRPGDRVVTSGDGGVFPADLLVGQVAQGPDRRLRVRLAADYGRLEFLRVLRSHELEPISDPGKLVAEPPAPPAPAAVEGADG
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MAHADNPRRPSPLLHAGVKRPRNADHSDSDTTHKDPGAFSPAVSTAVMKLQRACQELQLSSFPRVMTGREDERDEIYTALRSSIEQQSAGGPIYISGLPGAGKTSIVKEVIRTLETQRDAHELRNFAWVEVNGLQMPRPDVAYSVLWKALQPPETDAEGHKRMSAARLCEILQREFQTKNAARPMLLVLLDEMDFMLAGKNQVLYNLLEWQTSAAAKLVLVGIANTMDLPERLPTKIRSRLGGHRITFPAYTRAQLENIIQQRLLQLDIFSEEAIQICAKSLAHQSGDVRQALSLCRKSAEVCLHRLTTLDVNPSKEAAELFVTGEDLHEAQQAVSLSAPMSRLRACSKFECTFLVALRMEVRSNAARGGNKMGAELEAVIERFAILCKTHSFVPIPRLRGLLFICDELERSGIIRQISTRTSRYPLLELRCSHQELQDVFLMHSVGMQLIT
The following text describes a protein:
Function:
Serine protease with cytotoxic effect. Disrupts actin cytoskeleton resulting cell detachment in vitro.
Miscellaneous:
MISCELLANEOUS: Encoded on an unnamed 94 kb plasmid.
Subcellular Localization:
[Serine protease EspP]: Periplasm; [Secreted autotransporter protein EspP]: Secreted. Cell surface; [Autotransporter protein EspP translocator]: Cell outer membrane; Multi-pass membrane protein. Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane.
Domain:
The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface, with subsequent cleavage (By similarity).
Sequence:
MNKIYSLKYSHITGGLIAVSELSGRVSSRATGKKKHKRILALCFLGLLQSSYSFASQMDISNFYIRDYMDFAQNKGIFQAGATNIEIVKKDGSTLKLPEVPFPDFSPVANKGSTTSIGGAYSITATHNTKNHHSVATQNWGNSTYKQTDWNTSHPDFAVSRLDKFVVETRGATEGADISLSKQQALERYGVNYKGEKKLIAFRAGSGVVSVKKNGRITPFNEVSYKPEMLNGSFVHIDDWSGWLILTNNQFDEFNNIASQGDSGSALFVYDNQKKKWVVAGTVWGIYNYANGKNHAAYSKWNQTTIDNLKNKYSYNVDMSGAQVATIENGKLTGTGSDTTDIKNKDLIFTGGGDILLKSSFDNGAGGLVFNDKKTYRVNGDDFTFKGAGVDTRNGSTVEWNIRYDNKDNLHKIGDGTLDVRKTQNTNLKTGEGLVILGAEKTFNNIYITSGDGTVRLNAENALSGGEYNGIFFAKNGGTLDLNGYNQSFNKIAATDSGAVITNTSTKKSILSLNNTADYIYHGNINGNLDVLQHHETKKENRRLILDGGVDTTNDISLRNTQLSMQGHATEHAIYRDGAFSCSLPAPMRFLCGSDYVAGMQNTEADAVKQNGNAYKTNNAVSDLSQPDWETGTFRFGTLHLENSDFSVGRNANVIGDIQASKSNITIGDTTAYIDLHAGKNITGDGFGFRQNIVRGNSQGETLFTGGITAEDSTIVIKDKAKALFSNYVYLLNTKATIENGADVTTQSGMFSTSDISISGNLSMTGNPDKDNKFEPSIYLNDASYLLTDDSARLVAKNKASVVGDIHSTKSASIMFGHDESDLSQLSDRTSKGLALGLLGGFDVSYRGSVNAPSASATMNNTWWQLTGDSALKTLKSTNSMVYFTDSANNKKFHTLTVDELATSNSAYAMRTNLSESDKLEVKKHLSGENNILLVDFLQKPTPEKQLNIELVSAPKDTNENVFKASKQTIGFSDVTPVITTRETDDKITWSLTGYNTVANKEATRNAAALFSVDYKAFLNEVNNLNKRMGDLRDINGEAGAWARIMSGTGSASGGFSDNYTHVQVGVDKKHELDGLDLFTGFTVTHTDSSASADVFSGKTKSVGAGLYASAMVDSGAYIDLIGKYVHHDNEYTATFAGLGTRDYSTHSWYAGAEAGYRYHVTEDAWIEPQAELVYGSVSGKQFAWKDQGMHLSMKDKDYNPLIGRTGVDVGKSFSGKDWKVTARAGLGYQFDLLANGETVLRDASGEKRIKGEKDSRMLMSVGLNAEIRDNVRFGLEFEKSAFGKYNVDNAVNANFRYSF
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MIQACWTRGATFQASPTLSLYIPPQCRYLISSTSKSPDRYLHIFPLTSSCVYLDTQDIYTHVGAEGKMAGVGMNQLVVLLLLVALHGLLPPSAHAALQDGFYSASTNCNVDVEAVVWDVVEQHVSRFGDGGSGAGLIRLHFHDCFVKGCDASVLIDPSPVNPNPEKASPANGGLRGIDVVDEAKSRLEGACPGTVSCADILAFAARDAAYILSSGAISYSVPSGRRDGLTSNAADANRNLPPPFAQLDDLVRAFASKGFSREELVVLSGAHSIGRVHCSSFRDRIHPTVNETMDWSYGTYMQWQCPEDAGTEKWIEQDIATSGDLDGQYFENVLAGRVLFNSDWALIDDDQTRRMVEDNAMNQRRWAASFAAAMRKMSSLDALTGTAEGEIRKLCHVTNRG