lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Nonselective, voltage-independent cation channel that mediates Ca(2+) and to a lesser extent Na(+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as a ligand-gated ion channel. Binding of ADP-ribose causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. May have ADP-ribose pyrophosphatase activity which reduces ADP-ribose levels induced by oxidative stress, thus preventing the channel activation by reactive oxygen species.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The Nudix hydrolase domain is dispensable for ADP-ribose-dependent channel activation. May be involved in the regulation of ADP-ribose intracellular levels. Essential to prevent response to oxidative stress.
Sequence:
MGKDSFTPLYDGGDSSHVHLNKFGSNQLSQSKKSWIARNFSRRECIRFVPKSHDVSRCKCGRPRERHSQQALESGQGSEEWNVASCTTKHPTNAYGEIDFEGYGGQKRAPYLRMSHDTDANLVITLMLKRWNLEIPNLVISVTGGAKSFVLKPRLREMFRRGLIKAAKTTGAWIITGGTNTGVMKHVGEAVKEQQLMFGSDTQVNVIGIATWGIVDKQSDLISEKNGKYPALYSMEPTPGHQGAMLDPNHSHFFLVDDGTEGKYGVEIGMRSRIEEAIMKVKTDSRSEAGSIGVPVVLLVLEGGPNTVATMYELIKKKVPAVVIDGSGRAASVVGFAYNHTIKRNVDGQTINVIDPQYEDEVRAKVVEVFGAKGADKTYSMIKDVLEDEKMISVYSLDGEISQDIDLAILKALLKANRSSPVAQLNLALAWNRIDLAKSDIFTEEQQWTTETLSAAMLTALLDDKAEFAELFLQNGLSMREFLSLDILCKLYAEVPGNTTIKPLLQKEMGKRQVKTIDMDVVGEVIEELMGDMFESYYRKDGHYFGELASYAEGLVLKNRKSSKDLLANINRIDPLPTPYLDVFLWAVLCNRRELARVLWEAGREPMAAALMASRLLKRMASRAQEDNTITDISSDLYDHARLFEERAVGVLDECFNENETLSQTLLVRELDHYSRMTALELAVSAESQDFIAHTSCQVLLTRLWMGTMAMNTRWWKVLVCLYLPVLIFPIIYFVPDEQHERQAAEREHQKSLNQKSSKVKSHKEKNDAPVVPVYRSKEEKAVSNDEEARVGTENEEEDFQLEDYIPEIREDDSMEVIMRNKKLGFCDRIMHFYSAPFSKFVGNVVGYLAFIFLYAYVVLFNFPRFDPAKTLGGIHPTEIVLYFWVFTILIEEIRQLAAKPPKYIKDKVSVYFSDTWNFVDIFSLTVFIIAIILRFFTNSRIFTASRIILSLDIIFFIVRSLQIFSVNRLLGPKLVMIQKMMQDLAQFIIILAVFTIAYGIALHAVMFPSPGIYARNNTWVTITSVVQYPYWQMYGELFLDEIQGEKPKEFGEVDPDGRWLSPLLLAIYMVFTNILLLNLLIAIFNYTFERVQEDSDKVWKFQRYDLVQEYHSRPVFAPPLVLLGHILIFIRWVWRMCRCGHPPRGSTMKIGLSPAEMEQMDNWEFQAAEMYIHQQQQKNSGTLEERVRALGDRVDCINSQLNRVLDSMSGTRAHALTDGNGLEGGHDSEGRLARMEVELSSNSESLQKILALLQQQPPVKGQAAVPIQLTLLHYKARSSPYPGSTAKRFAVQDNMVDWQVPFPDYKPVNYTAPVVLANPVWADKDLMAMSPRPELPYNQMDHTCNVNRVSYNGTYVVKDGLPLNPMGRTGMQGRGLLGRFGPNHAADPVVTRWKRTSAGVMLQGGKKVLEFVAIQRKDNNQWAIPGGMVEPGQLVTQALKAEFGEEAMAKLNVSQEEKERIAKQIERLFQQGQEIYKGYVDDPRNTDNAWMETVAVNFHDDKGDLFGDITLQAGDDAAAVRWQRVSGNIPLYASHVSILEKVAKMRDAAF
The following text describes a protein:
Function:
Probable DNA-binding regulatory protein involved in cell-fate specification.
Subcellular Localization:
Nucleus.
Sequence:
MSQQFQASSGTGSASLREFKTEHEDLREDLPYSTLRTLFGITLDKDASQALNIALLLYGHNYPQQVVPPERNYAELDAQLESVVLEDHTAESTMEPGVSATVTEQLEEKSDKSSDGDGTSKRLTRSLKSVENETEEDHEEKEDEAPQSSRRESTRLKRKLLESQKTVQTTGNSSRASSKSQEKEVPGTKSQCAPKIRTTPEQSKAATKRQSSTTVRASSTCGSSVSSTSTVSSPDYTAKKGRATETPKLEELAPKKQSSATPKPGGEVCVWDGVQIGDLSAQMNAQIGDDEELDTVDIARRILSELKERCIPQTALAEKILARSQGTLSDLLRMPKPWSVMKNGRATFQRMSNWLGLDPDVRRALCFLPKEDVARITGLDEPTPAKRKKTVKVIRLTFTETQLKSLQKSFQQNHRPTREMRQKLSATLELDFSTVGNFFMNSRRRLRIDQQISRSSRSTGNGADTEDELDEEDVVVENVIADATDASNQPGPSHL
The following text describes a protein:
Function:
Involved in the resistance to the necrotropic bacteria Erwinia carotovora, probably via negative regulation of auxin signaling. Possesses lipase and antimicrobial activities, inhibiting germination of fungal spores (e.g. Alternaria brassicicola).
Subcellular Localization:
Secreted.
Sequence:
MENSRSTLIIFFAYTTIILIGSINCRDNNNNNLVTNQSALFVFGDSVFDAGNNNYIDTLPSFRSNYWPYGQTTFKFPTGRVSDGRTIPDFIAEYAWLPLIPAYLQPSNGKNQFPYGVSFASAGAGALVGTFPGMVINLKSQLNNFKKVEKLLRSTLGEAQGKMVISRAVYLFHIGVNDYQYPFSTNSSIFQSSPQEIYVDFVVGNTTAVIKEVYKIGGRKFGFLNMGAYDCAPASLIIDQTKIGTCFKPVTELINLHNEKLESGLRRLERELSGFKYALHDYHTSLSVRMNNPSKYGFKEGKMACCGTGPLRGINTCGGRMGVSQSYELCEKVTDYLFFDHFHLTEKAHQQIAELIWSGPTNVTKPYNLQALFELN
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
METKWLLSKVPDDKSRFEIELEFVQMLSNPWYLNFLAQHKYFEDEAFLQYLEYMEYWREPEYVKFIIYPTCLHMLTLLKNPQFRNDISRADLSKQVNDEIYYEWLGKGLQQYGSADDATLSQPQQEEDEKKVDVKKENE
The following text describes a protein:
Function:
Virulence factor; cleaves host immunoglobulin A producing intact Fc and Fab fragments.
Subcellular Localization:
[Immunoglobulin A1 protease autotransporter]: Periplasm; [Immunoglobulin A1 protease]: Secreted. Cell surface; [Immunoglobulin A1 protease translocator]: Cell outer membrane; Multi-pass membrane protein. Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane.
Domain:
The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface, with subsequent cleavage (By similarity).
Sequence:
MLNKKFKLNFIALTVAYALTPYTEAALVRDDVDYQIFRDFAENKGRFSVGATNVEVRDKNNHSLGNVLPNGIPMIDFSVVDVDKRIATLINPQYVVGVKHVSNGVSELHFGNLNGNMNNGNDKSHRDVSSEENRYFSVEKNEYPTKLNGKAVTTEDQTQKRREDYYMPRLDKFVTEVAPIEASTASSDAGTYNDQNKYPAFVRLGSGSQFIYKKGDNYSLILNNHEVGGNNLKLVGDAYTYGIAGTPYKVNHENNGLIGFGNSKEEHSDPKGILSQDPLTNYAVLGDSGSPLFVYDREKGKWLFLGSYDFWAGYNKKSWQEWNIYKPEFAKTVLDKDTAGSLTGSNTQYNWNPTGKTSVISNGSESLNVDLFDSSQDTDSKKNNHGKSVTLRGSGTLTLNNNIDQGAGGLFFEGDYEVKGTSDSTTWKGAGVSVADGKTVTWKVHNPKSDRLAKIGKGTLIVEGKGENKGSLKVGDGTVILKQQADANNKVKAFSQVGIVSGRSTVVLNDDKQVDPNSIYFGFRGGRLDANGNNLTFEHIRNIDDGARLVNHNTSKTSTVTITGESLITDPNTITPYNIDAPDEDNPYAFRRIKDGGQLYLNLENYTYYALRKGASTRSELPKNSGESNENWLYMGKTSDEAKRNVMNHINNERMNGFNGYFGEEEGKNNGNLNVTFKGKSEQNRFLLTGGTNLNGDLKVEKGTLFLSGRPTPHARDIAGISSTKKDQHFAENNEVVVEDDWINRNFKATNINVTNNATLYSGRNVANITSNITASDNAKVHIGYKAGDTVCVRSDYTGYVTCTTDKLSDKALNSFNATNVSGNVNLSGNANFVLGKANLFGTISGTGNSQVRLTENSHWHLTGDSNVNQLNLDKGHIHLNAQNDANKVTTYNTLTVNSLSGNGSFYYLTDLSNKQGDKVVVTKSATGNFTLQVADKTGEPTKNELTLFDASNATRNNLNVSLVGNTVDLGAWKYKLRNVNGRYDLYNPEVEKRNQTVDTTNITTPNNIQADVPSVPSNNEEIARVETPVPPPAPATPSETTETVAENSKQESKTVEKNEQDATETTAQNGEVAEEAKPSVKANTQTNEVAQSGSETEETQTTEIKETAKVEKEEKAKVEKEEKAKVEKDEIQEAPQMASETSPKQAKPAPKEVSTDTKVEETQVQAQPQTQSTTVAAAEATSPNSKPAEETQPSEKTNAEPVTPVVSKNQTENTTDQPTEREKTAKVETEKTQEPPQVASQASPKQEQSETVQPQAVLESENVPTVNNAEEVQAQLQTQTSATVSTKQPAPENSINTGSATAITETAEKSDKPQTETAASTEDASQHKANTVADNSVANNSESSEPKSRRRRSISQPQETSAEETTAASTDETTIADNSKRSKPNRRSRRSVRSEPTVTNGSDRSTVALRDLTSTNTNAVISDAMAKAQFVALNVGKAVSQHISQLEMNNEGQYNVWVSNTSMNENYSSSQYRRFSSKSTQTQLGWDQTISNNVQLGGVFTYVRNSNNFDKASSKNTLAQVNFYSKYYADNHWYLGIDLGYGKFQSNLKTNHNAKFARHTAQFGLTAGKAFNLGNFGITPIVGVRYSYLSNANFALAKDRIKVNPISVKTAFAQVDLSYTYHLGEFSVTPILSARYDTNQGSGKINVNQYDFAYNVENQQQYNAGLKLKYHNVKLSLIGGLTKAKQAEKQKTAELKLSFSF
The following text describes a protein:
Function:
Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MDFLKNKYNELTNNSTSSNVTADKYKDIKEPFLLHKLACEGKYDEIKQSIETIPYYKEFIDIRDTHGYPASHYAAHLGYGNIVELLLKSGADPDRKSAAGWSLLQEAIGRKDREIVTMVLLELKLKIEREFNKRVPTLVQALENIPDFEMELKWEVKSWVPLVTRFCPYDTYKIYKQGASLRADTTIIGMDGIKFIRGDLTFLYKNLRLFSLDNIKKQYSEMELVASKNPVVHEEEVDICLDQHIRRVKLMTDAIQFQPAKTWLGYEKTEAIGDKGDWSAKIFDVSNVDLKTCTRKSKRQPNHPSLNDMQNTTTGSKKDKKKQIKGDEIDEDEEEDQVITTNKDHLDESGKDHNVNSPVAQTKKYLDSLKHRTYTIRESTVKSKIFSDPHYFDAPKDFDPYTFEQNFDKTKVKSQGLLCEGETISERHRYFKGTIWISEDFPRKVADLLPIFEVLAPTNKLFSRLSEFIQLKLPSQGFPVKLDIPLVPTISATVIFTKYQEKEVDKNLFCVPTDYVEHKKQPKN
The following text describes a protein:
Function:
Acylhydrolase that catalyzes the hydrolysis of phospholipids at the sn-1 position.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MALSSSSAIRHQSFSLFATTHSSLVPPASHRTAAAIVEAAPLRERRASSLINIPATLSSLLHLHLERKPDDRSVGLPPPAVGRNNPTVSPKEDISSLFPEIHGYADWSPLLNPLHPWLRREIIKYGEFAQATYDAFDFNPLSEFCGSCLYGRHRLLDKLGLARNGYRVSKNVYAMSHVELPRWLERSLHADAWCTESNWMGYVAVSDDAESRRIGCRDIVVAWRGTIAPTEWFEDVQGKLEPFGEAHADVKVEHGFLGVYTSKSDRTRYNKTSASEQVMEEIKRLVSHYRQRGEEVSLTITGHSLGGALALLNAYESASTIPDLPISVISFGGPRVGNVAFGEKLKEMNVKVLRVVVKQDMVPKMPGILFNEGLKRFEHVTGTLEWVYTHVGLELGLDVRSSPYLKHGLDVAGFHNLETYLHLVDGFLSSDKEFRGNARRDVALVNKASGMLRDELHIPPCWVQMANKGMECNAYGRWVKPAREPEDIPSPYREEAQL
The following text describes a protein:
Function:
May be involved in vacuolar sorting and osmoregulation.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MTRNRVFGAAGTTIETASNSTANVTPVDTHHDNQYHSDNRAHEQTVDVDHEDEQDTESSTLLGHPSTMPAETSTFGFWWRWILNQTSMAVLLSILVLVLGSCVGIHFTMLNGLGLPGKVRSTTDPLVLDGSHPSGELAWQHITNITTHPHMFNSHENLRVRQYIIDQLVDMKNSLQSMYCAPTSDPLFVLDTFDNTNIMVENSNFAHNPPVIDYYESNNVLAKIQGRSATHEALLISAHFDSVMLAPGVTDDGISIGSMLATLQSLLIRHCRSPFKYDIIFNFNNGEEMGLFGANAFVKHPWIKNVKAFMNLEGTGAAQGTRSVLFRTNSLPIVEEYMSKAPFPHASVIINYLMGSVPSETDYRPYTVDARLPGIDIAFSANRYLYHTPKDDIAHAKPIAAQHMSENILSVALGLCEKDSILPTLGMSPDLSHQDTTVLPVPNFAYFDIAGAIGIVRSHGALIFSSSALLLICVGVSFLKLATLYYRIGFHRLVNQGIRPFFEAMALVWFSFLSVFLAVYMSSWIKHHFNPASSYGRPLLSFADTISLILGLFCLIQIIWPVIAVKLGLRDSAPLITYHELPSEPPHIDYYEDVANQEQVPASLQTDVEHGQSEDANSSSPIQTGGHILQSMRVVTPSGPSLAAWLPFGLLGFWLSLCTVNLVLNLFNISVMFYVYIWAFYSGVACILTLALESSLRRWYRLGVAGFEHEADQPEDHLKYSILKYYNQYFWLVNFVIATVVPFIQTFDLLHECLLDVPNMIAEGLSGPIYDTIVSGLVGLLLLNTLPLLSLCHRRLTASVMIFIFCVLWLTAVMTNGFSPDRPQGMTYMEAWDISNTTNSTSPLVTMNIMSTMQASEWKHRITTNPAIMSQLSTVLPKMELICDNSDNTCSVLNAALPIIDPNLPTDQLITIDMMVRETKTAMTVEGTFVGLPNSRICQLSTTSDEAGEFLVKGAWIDPFQTGKWITGSNSTIEVVGRPTPGVDYSVPLTIYRREFEGQGVKDKRIRVPFILQFDRGQNINKVRISVTCFLGIQVSPTFKVFEESLPDWMMFKDGSLKRRLLPFPFGRAGAVGVTKTFFVV
The following text describes a protein:
Function:
Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.
Miscellaneous:
MISCELLANEOUS: Present with 279 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSTRTKALNAYRHGLRATRIAFRNDAEVLLAARAKMRSGMLCPPDPKLTTEDQIQHLEDVAVFLRRNLVQGKKVDGSSTKEPRYHLNIHKDTELGDNETIADPTARVKTNLKARPFKCSDKKQ
The following text describes a protein:
Function:
Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 and GLI3 transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSHLFSPPLAALAASPLLYVYSPERPGLPLAFAPAAALAGPGRVEPPQKPPYSYIALIAMAIQDAPEQRVTLNGIYQFIMDRFPFYHDNRQGWQNSIRHNLSLNECFVKVPREKGRPGKGSYWTLDPRCLDMFENGNYRRRKRKPKPAAGSPEAKRTRVEPPESEVGCDVGSPDLATALPTRAPDRSQSPAVGTARPALLPWPGPEPRDPDADLTVQGAGAVASGQLQRPAHHLGSPLCPAPSGSPKGSKSKSFSIDSILAVRPTPASGAEAPGIPKPVPGALGSSLLAASSGLAPPFNASLVFDAHVQGGFSQLGIPFLSYFPLQVPEATVLRFH
The following text describes a protein:
Function:
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space.
Sequence:
MDRTRRFIFAIISAVVLCKHSQAEWNATKAPANRTVSCEHHANSSNCTDSKDEQKWSGHFSACPKEYKHFCIHGVCRFIEEQNTPSCRCEKGYIGSRCEYLDIDFHVGERRKIVIACVVAGLVFLILLIVFICVCTHKRYRPCRKKKRKKQTIDEDDKHTPLNAHEGVPADTSNTNAV
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSSSTASWSRYGAVPAPPPPPRPDANGDFEAAPSSSSSPASPPAATAAEAGVAFFSRAGASAAAAAAVGRPRAWREVLDHTAFSRPETCGEARARARRNLAYFRANYALAALVLVFLGLVYRPRSMLAFLALFVAWLALYFGRGGDAGPLVCLGRDVDDRVVLAVLSAATVLAVALTRAGLNLLVSLVLASALIGVHAAFRMNVYLDERDAFDADAAVSSFMGSTYGYSTLPK
The following text describes a protein:
Function:
Acts as a component of a complex regulating the turnover of mRNAs in the nucleus. Binds with high affinity to RNA molecules that contain U-rich sequences in 3'-UTRs. May function in complex with UBP1 and contribute to the stabilization of mRNAs in the nucleus. However, unlike UBP1, UBA1A does not stimulate pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MAKTLDKSKKRKLVKSKSTNFDKKQKINKQQQQPESSTPYSSSSSSSDSSDSESDNEFDPEELRELLQPYSKDQLVDLVCSASRIGSSIYSAVVEAADRDVTHRKIFVYGLPWETTRETLVGVFEGYGEIEECTVVIDKATGKAKGFGFVMFKTRKGAKEALKEPKKRILNRTATCQLASMGPAASGKGHDQPGPVKISMGSMANHGQPQQQQVQGQHVFNGGGMAASPFMLGNQYHPLYGAGMLGNPALAAAAAAGGGYMYPMLAGALAHGGLGSDMVQSSQMGGIGVDPSVGAAGLSALGSYFRGQSLPSTYPDSDAGGKRGTGKDSDAGGSSFHGYSNYS
The following text describes a protein:
Function:
Probable methyltransferase required to silence rDNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSRGGIFGDPRKKGRTATDKYSKKEPPQSKNRTETSSAAKVSKKAGALYGPVVVHSSGCASRDSANDRRGIPFKNKHEEREYKKAKHIPKYAPNPTGGKGENGEPTPRPSGASSAAQRRAIRRVRDDDSVLEHFRTKLSASTFRLLNEQIYNSPISSVAELLRDPSTYADYHNGYRQQIQQWPIKPYDVILQALLEDRRGRFVANKAKSMPGYIPSSWVIADMGCGDAQVAQALCPKGYTVHSFDLHAMNEYVTVANIAHVPLEKKSVDICIFSLSLMSTDYIKCLYEAFRILKPKRLLKIVEVRSRVPHPRRFAELVEGIGFTLDYHDTVGDYFVAYDFIKLDGQESANQHPKYDPQEVLVPSLYKKR
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGELLLARPLVVVGSANADMYVELDRMPKEGETLAARNGQTLPGGKGANQAACAARLSFPTFFVGQVGKDGNATMLRDALQTSGVRLDYLNTVSGPTGHAIVMLQPNGLNSIVIVGGANTAWKKRTGSSTIPVQAEETIRKAGALLLQREIPDDVNIEAAKYITVLSPNETELARLTSMPTETTQEVVRAANKCLDMGVKQVLVKRGVQGSMLAKADESPILQPAIPAPAVVDTTGAGDTFTAAFTVAILEGKEPAEALRFAAAAASVCVRAKGAIPSMPNRKAVDEVLKHEQYV
The following text describes a protein:
Function:
Functions in the bile acid 7alpha-dehydroxylation pathway, which forms secondary bile acids via the 7alpha-dehydroxylation of primary bile acids, and is carried out by intestinal anaerobic bacteria. Acts as a bile acid CoA transferase with broad bile acid substrate specificity. Catalyzes the transfer of the CoA moiety of secondary bile acid-CoA compounds to primary bile acids. Can use lithocholoyl-CoA, deoxycholoyl-CoA and allodeoxycholoyl-CoA as bile acid CoA donors and cholate, allocholate, chenodeoxycholate, ursodeoxycholate, and beta-muricholate as bile acid CoA acceptors. Also displays CoA hydrolase activity, being able to catalyze the hydrolysis of choloyl-CoA, 3-dehydrocholoyl-CoA, and chenodeoxycholoyl-CoA, releasing CoA and the corresponding free bile acid. However, this latter activity may not represent the actual activity of this enzyme, since using a transferase rather than hydrolase, the bacteria conserve the thioester bond energy, saving ATP molecules (Probable). Shows no hydrolytic activity with acetyl-CoA, isovaleryl-CoA, palmitoyl-CoA, or phenylacetyl-CoA as substrates.
Sequence:
MAGIKDFPKFGALAGLKILDSGSNIAGPLGGGLLAECGATVIHFEGPKKPDNQRGWYGYPQNHRNQLSMVADIKSEEGRKIFLDLIKWADIWVESSKGGQYDRLGLSDEVIWEVNPKIAIVHVSGYGQTGDPSYVTRASYDAVGQAFSGYMSLNGTTEALKINPYLSDFVCGLTTCWAMLACYVSTILTGKGESVDVAQYEALARIMDGRMIQYATDGVKMPRTGNKDAQAALFSFYTCKDGRTIFIGMTGAEVCKRGFPIIGLPVPGTGDPDFPEGFTGWMIYTPVGQRMEKAMEKYVSEHTMEEVEAEMQAHQIPCQRVYELEDCLNDPHWKARGTITEWDDPMMGHITGLGLINKFKRNPSEIWRGAPLFGMDNRDILKDLGYDDAKIDELYEQGIVNEFDLDTTIKRYRLDEVIPHMRKKEE
The following text describes a protein:
Function:
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate.
Sequence:
MKRVALLAVGSFNPPTIAHLRMLEVARSHLETINTQVVEGIMSPVADSYNNKPTLIKSNFRIQMVRAATKSSDWIRADDWECTRTTWTRTIDVLRHHRELVQEKFGSDVGMMLVVGGDVVDSFTRILPDGSNLWNSSDIRTIITEFGLIVLSREGSNPLNTIQSMPAISEFCDRIIQVKDEVCPSGVSSTRLRAAIMNKKSIKYSTPDEVINFIRENNLYQKI
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Sequence:
MAAAESPLETLQREITCSICLSYFKEPVSIDCGHNFCQSCITQCWGRADEENTSCPQCRRWSRKRSFRPNRELGNVVEVAKRLRLEASSSASTSSSFAAAAASSSASSQAGQRLCQKHQEPLKLFCEKDEMPVCVICRESRAHKAHPMLPIEEAAQDYKKQISTHVKALKERREKLKESKEDLECRSQADQDDVHIEKQKVEAEFNKIHEFLEKIERFLIIMLKKYDKEIVQKRDGAAKKLSEEIDSLDALITEVEDKCQQPASEFLQDIRSILSRCKDGQLPRLVEVSSSPTELEKKLGHFSLKNTVIKEALEKCRETMLSELAKARSIETAAKKASITLDPKTAHPLLVVSEDKKSVKRGEMVQPLPNNPERFEATLILLG
The following text describes a protein:
Function:
Probable transcription factor acting as a positive regulator in the ethylene response pathway. Could bind the primary ethylene response element present in the ETHYLENE-RESPONSE-FACTOR1 promoter.
Miscellaneous:
MISCELLANEOUS: Loss-of-function mutations (EIL1-1 and EIL1-2) in the gene show a weak ethylene-insensitive phenotype.
Subcellular Localization:
Nucleus.
Sequence:
MMMFNEMGMYGNMDFFSSSTSLDVCPLPQAEQEPVVEDVDYTDDEMDVDELEKRMWRDKMRLKRLKEQQSKCKEGVDGSKQRQSQEQARRKKMSRAQDGILKYMLKMMEVCKAQGFVYGIIPEKGKPVTGASDNLREWWKDKVRFDRNGPAAIAKYQSENNISGGSNDCNSLVGPTPHTLQELQDTTLGSLLSALMQHCDPPQRRFPLEKGVSPPWWPNGNEEWWPQLGLPNEQGPPPYKKPHDLKKAWKVGVLTAVIKHMSPDIAKIRKLVRQSKCLQDKMTAKESATWLAIINQEEVVARELYPESCPPLSSSSSLGSGSLLINDCSEYDVEGFEKEQHGFDVEERKPEIVMMHPLASFGVAKMQHFPIKEEVATTVNLEFTRKRKQNNDMNVMVMDRSAGYTCENGQCPHSKMNLGFQDRSSRDNHQMVCPYRDNRLAYGASKFHMGGMKLVVPQQPVQPIDLSGVGVPENGQKMITELMAMYDRNVQSNQTPPTLMENQSMVIDAKAAQNQQLNFNSGNQMFMQQGTNNGVNNRFQMVFDSTPFDMAAFDYRDDWQTGAMEGMGKQQQQQQQQQDVSIWF
The following text describes a protein:
Function:
Involved in membrane organization. Involved in a novel pathway of export of proteins that lack a cleavable signal sequence. Non-classical export pathway also functions as an alternative clearance/detoxification pathway to eliminate damaged material, when the basic repair pathway is not sufficient (By similarity). Regulates actin organization and subsequent morphogenesis and pathogenesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Accumulates in membrane domains at eisosomes.
Sequence:
MLAIGDVILRAFNFVFLVIALGLTGSLAATTITQHNPQINFAVFAAAFGLLTSSFYGVFAYFVAAFAWPVILFVFDFLNFVFTFAAATAIAAGIRAHSCSNQDYLDDNNIAQGSSGRCRKAQASTAFLYFSTFIFIASAIFSAISLSKGGLFGHSSRPAPRTGVPTMSQV
The following text describes a protein:
Function:
Receptor for artemin (ARTN), a growth factor that supports the survival of sensory and sympathetic peripheral neurons. ARTN-binding leads to autophosphorylation and activation of the RET receptor.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MVRPLNPRPLPPVVLMLLLLLPPSPLPLAAGDPLPTESRLMNSCLQARRKCQADPTCSAAYHHLDSCTSSISTPLPSEEPSVPADCLEAAQQLRNSSLIGCMCHRRMKNQVACLDIYWTVHRARSLGNYELDVSPYEDTVTSKPWKMNLSKLNMLKPDSDLCFKFAMLCTLNDKCDRLRKAYGEACSGPHCQRHVCLRQLLTFFEKAAEPHAQGLLLCPCAPNDRGCGERRRNTIAPNCALPPVAPNCLELRRLCFSDPLCRSRLVDFQTHCHPMDILGTCATEQSRCLRAYLGLIGTAMTPNFVSNVNTSVALSCTCRGSGNLQEECEQLEGFFSHNPCLTDAIAAKMRFHSQLFSQDWPHPTFAVMAHQNENPAVRPQPWVPSLFSCTLPLILLLSLW
The following text describes a protein:
Function:
Required for maturation of 30S ribosomal subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MNNKTNNNSVLFDLADGAVRPLGFEVLEVTQQREGRDLIVLVRIDRLDEQPVTMDDLTAASRAAEAEFDRVDPIEEEYRLEFESPGGKRPLLRARHFERMIGLKAKVRSLPGRGEHNFTAPIKAVEGDTVTFEHGGEDLSVNVADIQASLAEFPDRHR
The following text describes a protein:
Function:
Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly.
Subcellular Localization:
Periplasm.
Sequence:
MTIKNKMLLGALLLVTSAAWAAPATAGSTNTSGISKYELSSFIADFKHFKPGDTVPEMYRTDEYNIKQWQLRNLPAPDAGTHWTYMGGAYVLISDTDGKIIKAYDGEIFYHR
The following text describes a protein:
Function:
Involved in the degradation of para-nitrophenol (4-NP). Catalyzes oxidation of 4-nitrophenol (4-NP) at position 4 with concomitant removal of the nitro group as nitrite and production of para-benzoquinone.
Sequence:
METLDGVVVVGGGPVGLLTALKLGKAGIKVVVLEAEPGVSPSPRAVAYMPPTAAALDRFGLLQDIRKRAVMCPDFAYRHGNGELIAKMDWSVLSQDTQYPYMLLLGQNHVSNVIFQHLRELPNVEIRWNHRVEEVDQDDAYVTIETSSPGGTSRLRARWLAATDGARSTVRQKIGLTFDGITWDERLVATNVFYDFSLHGYSRANFVHDPVDWAVVVQLDKTGLWRVCYGEDASLSDAEVRRRLPERFKRLLPGAPTPDQYRVDHLNPYRVHQRCAAEFRRGRVVLAGDAAHATNPMGGLGLSGGVLDAEHLAEALIAVIKNGASTKTLDEYSIDRRKVFLEFTSPTATANFTWMKESDPAQRIRDDAMFKEAGTDRAVMRQFLLDLEKLNGRRVIEKKLKAA
The following text describes a protein:
Function:
Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Nucleus and/or cytoplasm.
Sequence:
MSEDTVGTVPNGESKEQVEPSVKGKGVSREDGALKEKSPSTKRKRLPNDKIGRLRDRIDEDPHDLGAWYELIGEYGSKGKHEELRDTFEQMLRPFPYVPKVWVDYINAELAFNDFQAVELLFSRCLLKVLSVDICSLYLGYIRRINPSNDAQARTTISQAYEFVIDTVGVDIDSGPIWADYIDFLRSAPANSTWEQQQKLDSIRRVYQRAIATPLLNVEKLWRDYDTFENSINRATARKFLAEKSPLYMNARTAMRELSHMLQGLRVYDHTFRRSFTPQESEAYRRWYHWAQWEMKDPLDLRAGKPLQTRVTYAFEQAMLYIPLSPRIWLDAFSYFIEINEEQRGLQALRRGMRYCPSSFLLRVRFAEHEEANKRMGEVRSTYESLIQALGQEIQKIPVPAENDPNRAKVPHELLRKRESLIHQHSMAWACHMNAARRIEGIKAARAVFTKARKAANQSYEVYIASAMMEHYCSKDSGIASKIFELGLKYFGNTPEYVLTYLDYLIFMNDDTNARALFEKAIAKLAPKDARLIYKRWLDYESKYGDLNAALQLSQRMSVVYPDETPRDIFLSRFGIADDDTINFVPSTPLHPGEAPQALGEVPVINVKRSTKSPEVAKEKPLLPEGTADESDNESTTSVSSSSSSEIAELEDTRLLPASQENASFYATKPPSIPTSKEPSFPPVILDLLAQLPPPHLFQGARFDSRKLIQLIANSTIPTMTPADIASKIKRARHI
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Miscellaneous:
MISCELLANEOUS: Present with 14900 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Domain:
The cytoplasmic C-terminal domain contains a functional dilysine-retrieval motif, which is involved in the retrograde Golgi-to-ER transport of the protein.
Sequence:
MRTDWNFFFCILLQAIFVVGTQTSRTLVLYDQSTEPLEEYSVYLKDLEQRNYKLEYLDINSTSTTVDLYDKEQRLFDNIIVFPTKGGKNLARQIPVKQLIKFFENEGNILCMSSPGAVPNTIRLFLNELGIYPSPKGHVIRDYFSPSSEELVVSSNHLLNKYVYNARKSEDFVFGESSAALLENREQIVPILNAPRTSFTESKGKCNSWTSGSQGFLVVGFQNLNNARLVWIGSSDFLKNKNQDSNQEFAKELLKWTFNEKSVIKSVHAVHSHADGTSYDEEPYKIKDKVIYSVGFSEWNGEEWLPHIADDIQFELRQVDPYYRLTLSPSGNDSETQYYTTGEFILPDRHGVFTFLTDYRKIGLSFTTDKDVKAIRHLANDEYPRSWEISNSWVYISAICGVIVAWIFFVVSFVTTSSVGKKLETFKKTN
The following text describes a protein:
Function:
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MRPPRGGGFRGGRDGGFRGGRDGGFRGGRDGGFRGGRDGGFRGGRGGRGGGFRDEGPPSEVIEVSSFLHACEGDAVTKLTNEKIPYFNAPIFLQNKTQIGKVDEIFGPINESYFSIKMMEGIVATSYAPGDKFYIDPSKLLPLARFLTQPKGQAQGGRGGGRGGRGRGGFGGGRGDFRGRGRGRGPPRGGGRGRGGGFRGRGRG