lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.
Sequence:
MRMMRARLSGCPSGYILQESLVYFIKEHNIVAPYKIERGKMEYVFQLEVSGKVEDVVETLLQLHRASCLDKLGDQMAMITAILQSRLARTSFDKNRFQSVSEKLHMECKAEMVTPLVTNPGHVCITDTNLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTAESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWVISDYSSPELDLSNPATFRDLSKPVGALNPERLERLLTRYQEMPEPKFMYGSHYSSPGYVLFYLVRIAPEYMLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYDEDASFLINSLKLDLGKRQGGQMVDDVELPAWASSPQDFLQKNKDALESSYVSEHLHEWIDLIFGYKQKGSEAIGAHNVFHPLTYEGGVDLNSIEDPDDKVAMLTQILEFGQTPKQLFVTPHPRRITPKFKSLSQASSYNASMTDSPVSPGEESFEDLTEESKTLAWNNITKLQLHEQYKIHKEAVTGIAVSCNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDTTVISSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHNDRLYSASWDSTVKVWSGVPAEMPGTKRHQFDLLAELEHDVSVNTINLNAVSTLLVSGTKEGLVNIWDLTTATLLHQISCHSGTVCDAAFSPDSRHVLSTGVDGCLNVIDVQTGMLISSMASEEPQRCFVWDGNSVLSGSRTGELLVWDLLGAKVSERIQGHTGAVTCIWMNEQCSSIITGGEDRQVMFWKLQY
The following text describes a protein:
Function:
Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation (By similarity).
Sequence:
MIAKYIIKHGLELAYDIKADAFMIFTETGKSYELLKSFLKKDEHSGIIKILDKISHKNVKIIVATPNQVTYKKISSENEENIYPIFIKHREDNRCMIISSGIVHALKMKILKENNKIVAVVGEPKTPGKLDTIMVVNVKEHVKTITLYELFETLDEKQKRTLKEIIKLAMEIGREGREGEYVGTIFVMGDTLNVMSMSKPLILNPFAGHNASIFDENVKGTIKELSSIDGAFIITDEGKVVSAGRFLEIKGDVNIPKGLGARHLAAASISKNTNAIAVTVSQSGGIVRVFKDGKIVFETDPRANILFFD
The following text describes a protein:
Function:
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MDGMKLSFPPESPPLSVIVALSLSASPVTIDSSAAATTVPSFVFSDGRKLNGATVLLRYVGRSAKKLPDFYGNNAFDSSQIDEWVDYASVFSSGSEFENACGRVDKYLESSTFLVGHSLSIADVAIWSALAGTGQRWESLRKSKKYQSLVRWFNSILDEYSEVLNKVLATYVKKGSGKPVAAPKSKDSQQAVKGDGQDKGKPEVDLPEAEIGKVKLRFAPEPSGYLHIGHAKAALLNKYFAERYQGEVIVRFDDTNPAKESNEFVDNLVKDIGTLGIKYEKVTYTSDYFPELMDMAEKLMREGKAYVDDTPREQMQKERMDGIDSKCRNHSVEENLKLWKEMIAGSERGLQCCVRGKFNMQDPNKAMRDPVYYRCNPMSHHRIGDKYKIYPTYDFACPFVDSLEGITHALRSSEYHDRNAQYFKVLEDMGLRQVQLYEFSRLNLVFTLLSKRKLLWFVQTGLVDGWDDPRFPTVQGIVRRGLKIEALIQFILEQGASKNLNLMEWDKLWSINKRIIDPVCPRHTAVVAERRVLFTLTDGPDEPFVRMIPKHKKFEGAGEKATTFTKSIWLEEADASAISVGEEVTLMDWGNAIVKEITKDEEGRVTALSGVLNLQGSVKTTKLKLTWLPDTNELVNLTLTEFDYLITKKKLEDDDEVADFVNPNTKKETLALGDSNMRNLKCGDVIQLERKGYFRCDVPFVKSSKPIVLFSIPDGRAAK
The following text describes a protein:
Function:
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles.
Domain:
The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.
Sequence:
MSSHKGSAGAQGNGAPSGNREADTVELAELGPLLEEKGKRAASSPAKAEEDQACPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEGRWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGFVKATTVGQMGWFFLMAVMYITGAGLYAARIPERFFPGKFDIWFQSHQIFHVLVVAAAFVHFYGVSNLQEFRYGLEGGCTDDSLL
The following text describes a protein:
Function:
Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p-hydroxybenzoic acid derivatives (p-HBAD).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MGLVWRSRTSLVGQLIGLVRLVASFAAQLFYRPSDAVAEEYHKWYYGNLVWTKTTYMGINCWKSVSDMWNYQEILSELQPSLVIEFGTRYGGSAVYFANIMRQIGQPFKVLTVDNSHKALDPRARREPDVLFVESSSTDPAIAEQIQRLKNEYPGKIFAILDSDHSMNHVLAEMKLLRPLLSAGDYLVVEDSNINGHPVLPGFGPGPYEAIEAYEDEFPNDYKHDAERENKFGWTSAPNGFLIRN
The following text describes a protein:
Function:
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MSRRHSVNRPPTPDRDGAERVKEPTLIDIVNIKLTESGEKERLMELVRERLVECGWKDEMRSLCRAFVKNNGRDNVTVDDLVRAITPKGRASIPDSVKAELLQKIRTFLVSVAH
The following text describes a protein:
Function:
Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body. Required for establishment of left-right asymmetry during embryogenesis. Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Cytoplasm. Note=In the cytoplasm, it is localized in large vesicles. These vesicles correspond to lysosomes and/or endosomes. Can shuttle between the cytoplasm and the nucleus in a manner correlated with Hh activity.
Sequence:
MPFYDNVYYPYPSDPPGTHSSAGIPSLLSSPQSQPSSGSQSRPAPSTMSGPLTSSGASTSIPPPFKFRSRRENVDWRRINAVDVDRVACEMDFQALQEHINAVTFCSVEGERCHRCQSPVDPALIKLFRLAQLTVEYLLHSQDCLSISLQAAEERLLAEAREREQICVQLQKKTQDAKALKEELKQRKKIIASQQAMFSAGISANYHKCQHCEKAFMNASFLQSHMQRRHPSEFDMKLMTDNQKKIQTVKLQDEINKLQEQLTLVTSQMETQQKDYTAKQEKELIQRQEEFKRQLEIWKEEEKMRMNSKIDEVKQACQRDMDSINQRNRNLETELLKLQQKNIQESMQSVQTQPNASTSNEHWQEVVKLQQKLHKQEVKWTGKMQKMKEDHDREKSLLQEELCKVSSAVSEGMEESRRQVQELSHRLQEQQQIITSQNKQMKQISSKPPTITVQREGVSTPSPETKAKVVVSEQSNSVHKLDPIVELSEEDKDSSSISESPTENRSWQKEVQELLKNPGLRRDMRLAAQHNLDDRLQSLGIKGVSGLSKNLYKSSMTQIISDRRKKLEEDPVYRRALKEISHKLEQRVKERNTEQPVKSKLHEQVVQSRPRSSSFPSTVTRVMSGPASKQQRTPQPVPRSRTNVPHKTSTPLQHRRTPPFSSDEDSSEEEEEEEEEEESSDEESPQMQKKTVLVNSSTAKAQNTAKTQSTAQSVRSAVALTSAEPTNVTTLSDSDWTDGSEMEEINLSQLHKHTDQNGNLKNVTHSNVKALGKSLEKQLAARGPKKPAGGVNTFLEKPTDVRNTRQNAKKELKYSDDDDDDDDDWDISSLEDVPAVAKPTQCPVPVRKSLDKSQDTSTSVWGSSTGKGHKPGLTDAGTASTLKSSLVTVSDWDDSDEI
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEDGDEVVEPIEPESEDIVNLTKRLGVDLVLESNDDWKIQEIGFDGVERYLQPETFTDHVGKLARKVEWTKLVGTKSPYENSKVDPEDELDDENVAKGGLNEELVTPEAGPWSSVAKYLHESLNQLNSLLDVISVTKSTDYMKALTVLDPITVQEPTPETISTNRGTQWIWKRRALQEAVQVLDMAQKQRQRASSNLGLSADYMAHLQRTKFFEELREMREIWRVRKVGDYICGDLSYHIFGWKYDTPAIFDISRRSLSNNMENLSIIEVSVPKDLARRSMLAVSIVQDDIQSGNGLFRDPKDKKYTYSYRESDSEKVKLLHWKDSLKWAQNTLLLRDVFKTICTDAIKLRNRLSIIRDNVLLIHLFDDYLLRFELQWFPFQTGEIKEEGDIYLNRVLREMIIGFECTKFIRPQFFCSMPVTHLPEALDLRGCGGFNTAQIEERAVRSRSILQRMLDVASHRALVTMVSDVAERVSRISLDPTVQYRWLNCGRTTSRMMFNMTSKDFEMYIGTISSVRSVFFANISSDGVEVETKDGIKMKCQRDPARVMYACQYAMCCYSVTMVSTMSRNNNWVTPFQTMCANVFALDERGNPAPNIVLCNQAATRSILFVFHVGMEPEVFVRRFIVNEETMKPEEHEWKKLCYSRLHGATLCRKIDALLVFLRDH
The following text describes a protein:
Function:
Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit dpm1 to the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKRYQKVFITFTFLMTFWLLLVLEKIQLNLSPSIQSIIPFLPLYAVVCFGSYSLGVIAYNLLIMSDCKEASESLFDEIKEAKESLRAKGMKL
The following text describes a protein:
Function:
In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.
Sequence:
MLKNVLRRGALRLVRQRASYATSALTPQQKQIVKATIPALEQHGVTITTLFYKEMLERHPELNNIFNSSHQATGVQPAALAHAVWAYASNIDHPEALATAVSRIGHKHASLGVRSEHYPIVGEHLLRAIKKVLGDAVTPPVADAWTAAYQQLADIFISFEDDLYKQATQTPGGWTGWRKFVIADKVHESEEIISFQLVPQDNGRLPTYKPGQFVSVRCFVPELGVYQPRQYSLSDIPNQRYFQISVKKEFASGARPAGRISNVLHESLPKGSEVEISMPFGDFVLDTNATTPVVLMSGGVGLTPMMSMLKTVTNNSKSRPAVFVHAVRNGRVHAMKETLANIMTDNPQVKRAIFYEQVEEGDKQGVDYDYVGRVDVSKIKDLVFLPDADYYICGPSPFMKAQSEALETLGVRPDRIHMEVFGSPTP
The following text describes a protein:
Function:
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
Sequence:
MSPCLRLLRPTAKVSSRCGATRRFLSVPAAELRFGQPLHETHPHLLKAGEVTPGITALEYFERRSKLAKELPPNSIAVLAANDLKYASGAVFYKFHQDPDFRYLTGFLEQDALAIIEKTDEHEHAFHLYVRPKDARREAWEGPRSGVEAAEDVFNADITGSIDDLPKILPEIVKRSKTVYTDLPQNRISKNFASRYLAAAEPARTGGIAKVFRDNEASIRPLRPLLNELRVIKSEAEIVNMRRAGQHSGRAITDAMRQSFSYEKDLDSFLDYWFKQDLCDGPAYVPVVAGGINANTIHYVSNDMALKPDELVLVDAGASYGRVRHGTLRARGSPGLSRSRLLEKGMVVTVEPGIYVPDDEKWPKWARGIGMRIEDSVMVDEESPYVLTTEAVKEIVDIEALRGSETKL
The following text describes a protein:
Function:
Involved in pre-mRNA splicing. Interacts with prp6 and prp13. May also be involved in the regulation of the G0-G1/G2 transition. Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region.
Subcellular Localization:
Nucleus.
Sequence:
MANFYPDFLNMQPPPNYVAGLGRGATGFTTRSDLGPAQELPSQESIKAAIEQRKSEIEEEEDIDPRYQDPDNEVALFATAPYDHEDEEADKIYQSVEEHLSKRRKSQREKQEQLQKEKYEKENPKVSSQFADLKRGLSTLTDEDWNNIPEPGDLTRKKRTKQPRRERFYATSDFVLASARNENQAISNFAVDTQAGTETPDMNGTKTNFVEIGAARDKVLGIKLAQASSNLTSPSTIDPKGYLTSLNSMVPKNANDLGDIRKARKLLQSVIETNPKHASGWVAAARLEEVANKLSQAQSLILKGCENCSRSEDVWLEAIRLHPAAEAKVIIANAVKKLPKSVTLWLEAEKLENQAQHKKRIIKKALEFNPTSVSLWKEAVNLEEEVDNARILLARAVELIPMSIDLWLALARLETYENAKKVLNKARQTIRTSHEVWIAAARLEEQQGNVSRVEKIMARGVSELQATGGMLQRDQWLSEAEKCETEGAVITAQAIINTCLGVGLDEEDQFDTWLDDAQSFIARKCIDCARAVFAFSLRVYPKSEKLWLRAVELEKLYGTTESVCSILEKAVESCPKAEILWLLYAKERKNVNDIAGARNILGRAFEYNSNSEEIWLAAVRIEFVNNENERARKLLARARIESGTERIWTKSISLERILDEKDRALQLLENALKIYPHYDKLYMMKGQIFEDKEQIELARDAYLAGTKVCPYSIPLWLLLAKLEEKQSVIRARVVFDRAKVKNPKNEFLWLELIKMELRAGNISQVRAALAKALQECPSSGLLWTEAIWLEPRAQRKTRATDALRKCEGNAHLLCTIARMLWLEKKADKARSWFLKAVKADQDNGDVWCWFYKYSLEAGNEDQQKEVLTSFETADPHHGYFWPSITKDIKNSRKTPQELLHLAINVL
The following text describes a protein:
Function:
Sphingolipid-delta-4-desaturase required for the biosynthesis of delta-4-unsaturated sphingolipids and derivatives.
Subcellular Localization:
Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein.
Sequence:
MEGGNEKQQEQEVEGVMASDFFWSYTDEPHASRRKEIISKYPQIRDLFGPDPWAFIKITAVVLLQLWTSTILHNAGWYKILTVAFFFGSFLNHNLFLAIHELSHNLAFSTPTYNRFLGIFANLPIGVPMSVTFQKYHLEHHRFQGVDGIDMDIPSRVEACLVTNAFTKSIWVVLQLFFYALRPLFLKPKPPGLWEFTNLIVQLTLDAALLYFWGWRSFGYLILSTFVGGGMHPMAGHFISEHYVFSSDQETYSYYGPLNLMAWNVGYHNEHHDFPRIPGNKLFKVKEIAPEYYENMKSYTSWCQVIYMYVMDRSVGPFSRMKRKQSKSYGSGSSNTTTVTTTKKIE
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDFKLIRRVHKIGQWLAITPSNYDKKHVSKIQKSYNLLIFTILTFGLIKIIFYTRRTINTVNLILYYFIEMSLYLLNINSIIVTIFWKNNQWCQLYKNLKRINSTEDNTRQFFFANFIYLMAEIITSASLYEKYHQINIFRRYQLLAQMYYTFLIYVTVRMFLVRYQKLGELLTRQLDLPPQETLPVVRKVAKLVSFLRKSSEIFNDLFDLSLSCIIIFTILNMIFNIFWLVSDGGSTVLDDILVILVFKQTPTLVWTLIVILMCDSVTNEVKKIHFTCYQLYFNGTRGQKTELHQLTKEINQNLPKFTAIGFGVVNKTTIISMVATIINFIIFAMQLTQQN
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MAGTTRCSIRGSNAPGLALPCLLLLLLLAGAGVSNGQLQVGFYSKSCPDAESTVASVVRQSGSADPTILPALIRLQFHDCFVRGCDGSVLIKGGGNNNNNAEVDNGKHQGLRGLEIIEGAKTQLEAQCPGVVSCADIVVLAARDAVAFVRLRMIPAGRRSTCPRGGSTGRCPTCGTPTRCRTCTTASTRSAPSSAPTALTRRTSSSSPLRTRWARRRASSSRTGSTTSRCRAAGGARTRPSRRASCRSSRPGARRGTSTRAWPWTAAARTSSTPPSSATSATASPSSAPTPRSTTTRPRSTSSTPTPACSATSSGPTSGRTSRTPWSAWAASAWSPAASRARSGRSAPSSTD
The following text describes a protein:
Function:
Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan.
Subcellular Localization:
Secreted.
Sequence:
MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKRRAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNNKLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKRSDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNKFLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVIK
The following text describes a protein:
Function:
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
Subcellular Localization:
Endoplasmic reticulum lumen. Melanosome.
Sequence:
MLRFSGRNMKVLFAAALIVGSVFFLLLPGPSTADEKKKGPKVTVKVYFDLRIGDEDIGRVVIGLFGKTVPKTVDNFVALATGEKGFGYKDSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGGSAEGGDHQDRWARQAPEGCDNCRLWQDRGGEALCHRQGVGPGDFLPLSNHLCSRVAPQGVKTACHRALRSHWPQWWHLTEWTPPLTFHRAQFCNKLLPTLTNKKKRWVFYNLCVGSVLGPAAPPPQSVSRCAWDLWQRVLSPLWTLA
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MEVDSPPEITPLRPRDRIIRRLALLGVPEEFLDQFQRGLVAFVKKNKQRIPELVSAILPADEEVEEVLNEAKPGSKKQSAAVTMKNRFRESMVWLQWLMFEGEPSSALKNLSKMSVGQRGVCGAVWGQNDIAYRCRTCEHDPTCAICVPCFQNGNHKDHDYSVIYTGGGCCDCGDVTAWKREGFCSKHKGTEQIQPLPEEFANIVGPVLDCVFVSWKNKLLLAETTYRETPRASDHVTERKKVANELTFVVVEMLLDFCKYSESLLSFVSKMILSSGDLLGILVRAERFLTEAVVKKLHELLLKLLGEPIFKYEFAKVFLCYYPAVVSEARMEFSDISFKKYPLLSVFSVQIFTVPTLTPRLVKEMNLLPMLMGCLQDIFVSCAGDDGRLQVTKWLNLYEITVRVIEDIRFVMSHAVVPKYVTHDKQDISRSWMRLLTFVQGMNPQKRETGIRIEEENESMHLPFVLGHSIANIHSLLVDGAFSVASDKMDEGLQDMDGRDSLRHAKVGRLSPESSVCSAVGRSSSFACASKVSEDKSDALSDLLIPPSVMWLTYECLRAIENWLGVDNTSRAFLDASSPSTSNFSGSNFSALKKTLSKIRRGNIFGRLASSSEDHGKQCSSHLHSDCNMSVDFQNGKGAGQETKLMVPDEIDSVNACSPAGLDDSAMEVDGAMDLDALRVLSSSDWPDITYDISSQDISVHIPLHRLLSLLLQKALRRCFGEVPDLASATSANSSSAILTDFFGNFLGGCHPYGFSAFVMEHPLRIKVFCAEVHAGIWRKNGDAALLSCEWYRSVRWSEQGLELDLFLLQCCAALAPADLYVNRIVKRFGLSSYLSLNLERSSEYEAVLVQEMLTLIIQIVKERRFCGLTKAESLKRELIHKLAIADATHSQLVKSLPRDLSKFDQLPEILDTVAAYSNPSGFNQGTYSLRWTFWKEMDLFYPRWNSRDLQAAEERYLRFRSVSALTTQLPRWTEIYPPFKGVARIATSKAVLQIIRAVLFYAIFSDKSIDSRAPDGVLLTALHVLSLALDICFQHKESGDQSCYDGDVIPILAFAGEEIYEGPHFGAGQQSLLSLLVILMRMHKKENLDNCLEAGSDLSSLIGSLLKKFAEIDSGCMTKLQLLAPEVIGHVLQSSPNGDTYTSGSISDSEKRKAKARERQAAILEKMRAEQLKFMASVNSTVDDASKCEQEVCNPDVEDDSEESAEVVCSLCHDPNSRNPISYLVLLQKSRLLNFMDRGPLSWEQPRWINKEHMSIIKGEVTDQSETSSSSGGSGVVPSYPLKQLVQDAITKFACHGQPRDVEALLDFFKGRFHELKNIQVPRELNDESEKTLCTFETMEDAMYLSIQKELHDKMLHSKLTEDKGFSTPEGDQEKTEHAEFMLLGKYTAALSRETTENPSSSESPNEKVPIDSSRLSAYDGFGPIDCDGIYLSSCGHAVHQGCLDRYLSSLKERYLRRIVFEGGHIVDPDKGEFLCPVCRRLANSVLPALPGLFEKVSKESLHSGVSSSHATGPLVKSGGEINSLQLQQGLALVQSAAKASGKVGNLKGFPLQRCGRMTSNLEISRLLCKMYFPTKQDKLSGSARVSHPMLMWDTIKYSLLSIEIAARSGGKYATPSYDLNALYKELESSSRFVLSLLLKVVQSKSKNSLHVLQRFIGIQSFAESICFGVSIDHGSETCGQGAMLRILEHVDMAVSYPDIQFWNRASDPVLARDPFSSLMWVLFCLPNRFLSCEDSLLSLVHLFYVVSVVQGIIAYLGKNQCDMSKLGVDDCLVTDVSKLMGESGCPQQYFVSNYVGSSCNSNIKNIVRSLSFPYLRRCALLLNLLNYNAQAPFFERYNVLDRSHDIGDMMDTTYVALVELNEVQEIERMFKIPTLDVILKDKVVRSMVQKWFRHFCKEFEVQRFRGSIHCNPAVPFQLMRVPRVYQDLLQRYIKQRCPDCKSILEDPALCLLCGRLCSPSWKSCCRESGCQTHALACGSGTGVFLLIRRTTILLQRCARQAPWPSPYLDAFGEEDVEMQRGKPLYLNDERYAALTYLVASHGLDQSSKVLGQTTIGSFFMV
The following text describes a protein:
Function:
Male-specific phermone which is recognized by the Vmn2r116/V2rp5 receptor in the vomeronasal organ (VNO) and enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation.
Subcellular Localization:
Secreted. Note=Secreted by the extraorbital lacrimal gland into tears.
Sequence:
MTSLPVLLFLIILLLPSMITEGRVLTQTGKEATIFADQKTNHEADLKNPDPQEVQRALARILCALGELDKLVKDQANAGQQEFKLPKDFTGRSKCRSLGRIK
The following text describes a protein:
Function:
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.
Sequence:
MASNSPSSNRLRVGYAFPPNKERNVIRPSLIDYAKLHSVDLVRIDLQTPLLHQGPFHCIIHKLYDDAWAENLQEFASKNPDVVVVDRPDLISKLYNRVSMLDVVSQVKVSDSDVKIEVPKQILVKQEDEAIDSIMKLELKFPVIAKPMESDGSAKSHEMSLVFNRRGLKDLNKPVLVQEFVNHGGVMFKIYVAGDQSMCVKRKSLPDVEETEEELEKKTEGAMKFSQISRAEEKSEKCNGEAKKEDEEEIEMPPEKIVREVSRGLKEAMGIRLFNFDMIRDRNNGRYYVIDINYLPGFAVLPEYEPFLTKFFKEVREKKVDVDEVASATENDKQNPRCCSCFH
The following text describes a protein:
Function:
Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
Subcellular Localization:
Nucleus.
Sequence:
METETPMDVETKSTTSNTNDNNNNTTIVKTTSNIIKEGDHVILDINNGEKFSVIKVKLGSKVKIGKKQILINSIIGESYYSSFQVSNEKNTLERITQKEIDDRLNNLVELNQNDADNRNLDQNNTAQKLTQEDINEMKQKGTDSNTIIKTIVENSESFKTKTSFSQIKYLKKKIKKYSTIVKIIKPTLKSLTEAYYKKDSRKICGLRFDSFGQLLTLGNIRANSQVLVVETCMGLVTGSIAERMNGQGTILSAYIGKGPSLSIVNNFGFNTDVLNTIYPFNLNITSVLNKGEDISKLPPTASSGIYDKQVKEKEKEKEKDENVKDEKESGEEAKTIINQRNDTSNENIVKLLKDGGVWSLVIVTKYSPLNILLSCWPYLNSSGSFVIYSQFPQPLMEVHQFLHKNQMAVNQQISEIWMREHQVLPKRTHPMMGMDGASGFILYGTKVTKPIQKSTTTTTTTTTTTTNNSINPTKTTASLDIENKVIDATTSSSSSSTAAATTTEEDKEDSESALKKRKIDE
The following text describes a protein:
Function:
May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNASAPSSSLSTFKDKNKNDGLKPKQADSVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVPLGSNAREESSIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQDKKSMGLPPRIGSLASGNVRSLPSQQMVNRLSIPKPNLNSTGVNMMSSVHLQQNNYGVKSVGQGYSVGQSMRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSYGLGSEQRSQAPARYSLQSANASSLSSGQLKSPSLSQSQASRVLGQSSSKPAAAATGPPPGNTSSTQKWKICTICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLSFDLTLQQGSHTNIHLLVTTYNLRDAPAESVAYHAQNNPPVPPKPQPKVQEKADIPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKTNAPSRLNQSPSLAPVKRTYEQMEFPLLKKRKLDDDSDSPSFFEEKPEEPVVLALDPKGHEDDSYEARKSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKCVRDCEKYKPGVLLGFNMKELNKVKHEMDFDAEWLFENHDEKDSRVNASKTADKKLNLGKEDDSSSDSFENLEEESNESGSPFDPVFEVEPKISSDNPEEHVLKVIPEDALESEEKLDQKEDGSKYETIHLTEEPTKLMHNASDSEVDQDDVVEWKDGASPSESGPGSQQVSDFEDNTCEMKPGTWSDESSQSEDARSSKPAAKKKATMQGNREQLKWKNSSYGKVEGFWSKDQSQWKNASENDERLSNPQIEWQNSTIDSEDGEQFDNMTDGVAEPMHGSLAGVKLSSQQA
The following text describes a protein:
Function:
E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
Sequence:
MNKRKIDMLMKDCYELTVTALTIRKVEERLLELFSEGVLNGTIHTCIGQEWTGVAVANALQAGDTVFSNHRGHGHYIALTGDVYGLIAEIMGKDDGVCGGVGGSQHLHTENFFSNGIQGGMVPVAAGRALANALQGNNAISVVFIGDGTLGEGVIYETFNIASKWQLPLLVVLENNQYAQSTPTSLTLAGNIRDRVRGFGIEYIKCDTWDIAGLLDSAKEAVDCVRKNQKPVLLEIDTYRLKAHSKGDDLRDPVEISRYAGQDSINALLESDVPRVAETVNQIDSNIQQAITKAREATLCSFAPASNSVRQYQSVTWRTESFARQRIITSINLSLQSLLENNSKAVIIGEDIEAPYGGAFKATKDLSTLFPGRVKNTPISEGAITGVGIGLALSGFLPVVEIMFGDFMTLTFDQLLQHAGKFCEMYGKDLDVPLIIRTPMGGRRGYGPTHSQSLEKFFLGIPNLEVIAYNHRVSPALIFGNLCKTIRRPTLIIENKVLYTQHVDSTPMPGFRINISDELFPTVRISPSTGDPQVTLVCYGGMLAEVEIAAAAAFDENEILCEIICPSIINPLNAYPILESARKTRRLITVEEGPSIAALGSEVAARILEHSLPIAHYSRIGYDSTIPSSASRESRLITNAESIFERIVEIFK
The following text describes a protein:
Function:
Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEEMVSQNTEGDKSIDDHWQTEGAETQPGLHETFPLGVLKARVALLATAIGGPDHTSEQEAAPYKLGDDCLACLKDLKRWFVLVDQKQKRWDVASAAAEFRILEEDLIPILVQWEQKMSQGIKQSKVSGLPLSECIKNKQYHGKIALNAFQLMVWMTWPMTLNEESSKNQVHHYSGLKKHQLAYKKAILQAHGGKVVKAAVRIATEVIKIDRLDRSVQDNSLIRLVLNFLRNILAIEPGEVTVSAKQLSKSRNINTSDMLPPNISVDDICLNSVVSVFKKFKVFPFLLTISSSMGHEFEAEYVCLPLLEVAFYLTKDIDPHLLSLKADNPPQSLQNCGNKVSNGQGVVSGQLGMELIHLLDKERHHKMSQIRSSSTRHSRFGGFFSIQTPNNGRLTISNGHSALDHDLALNNIDKKKKWNKTTRNTAEAVQGIPVGVLNGEFNLTFLSHDNRSCLKWFLANFVDSSFNILLKNLIDYFTADEFNQQILQKLQFLLFYAWFLKFERDRCQKGETDGIFVSEALQDTSHILIIKFLREAHELKKWPLVHAAMLAITELLNYLDVLGEDWEEDVVGIYTKIFSNERLKLFSTIPRTASRHSLHYVKACINMNHAIMTTLERFNKNNKDLIIKGFRKRMITRFIVKEGKTTSGDVNGNKNGQDTTRDADEDAISSDEETNMISARLDFKKVLDAYFNGTVIDTYIFYLKHFTELTEEDIKRVLYFLNHILCSNEESFLFRVDFMIVLKEMLAPGGLSVTGHTRIRINEFSDHFMAKLKRKLEKSPFWYINILFPNLHDRELGYYLRYGQQRPNTQSIHKVVAPTMFKHIEGEENMSEQQLKDLKIGVLVSTLLDDGKNHFVEEINRIFKLVVEGYEKHYQNNERSATLHYPRVDFRSDMFDMKRALLFDSDLRALMTTLGYHVADTEVEPCYIGGIFYFPDLSSALNSLEQYMAIPFHTPNGLPSSSYLLRSIDYKSGVDADAKVGEAMRIDQFSDEMADMALSENANRYFEDLNRMEERLEGKQIPRGTAKKRSAIKPKSRKSQPTGIGGIDDDTPVINKSKRKKQLFLSNEFIMDSDDEEELVASPIFYENEIYLRFILNKYQGNLPSHLFSVFSRFANERGRMAGAVVGDYTDLFNGPVPSIEELKSMENSTTHHGLKEILQLQPRDHLSLSPNNENNSAHSSENLSSDSENDNITNDIPLSDSEYNSSNSSQYANTAKTSIIDPPSSKTSLLKLALTHEADVESEDDFIPRKRARKVRLEDGEEY
The following text describes a protein:
Function:
Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Subcellular Localization:
Fimbrium.
Sequence:
MHPTQRKLMKRIILFLSLLFCIACPAIAGQDIDLVANVKNSTCKSGISNQGNIDLGVVGVGYFSGNVTPESYQPGGKEFTITVSDCALQGTGDVLNQLHIDFRALSGVMAAGSRQIFANEISSGASNVGVVIFSTQDSANTFNVLNASGGSRSVYPVMSDDMNGSSWKFSTRMQKIDPALSVTSGQLMSHVLVDIYYE