lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems.
Sequence:
MPHWAEERHRRESNYVALEAGLDEGESIRRSEHSRSGCGADAGCWRCRGGPGRGSRRSRRSRGPGGTAGPVDPPAVDLLAPPPDPLALPPALDPLAPPPPDPLAPPPPDPLAVPVAAGPVAGQDPTSFVGPPPFRPPTFNPVDGAMVGVAKPIVINFAVPIADRAMAESAIHISSIPPVPGKFYWMSPTQVRWRPFEFWPANTAVNIDAAGTKSSFRTGDSLVATADDATHQMTITRNGVVQKTFPMSMGMVSGGHQTPNGTYYVLEKFATVVMDSSTYGVPVNSAQGYKLTVSDAVRIDNSGNFVHSAPWSVADQGKRNVTHGCINLSPANAKWFYDNFGSGDPVVVKNSVGTYNKNDGAQDWQI
The following text describes a protein:
Function:
Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity; extends the O-linked fucose on the Notch EGF repeats. Boundary-specific cell-signaling molecule that is responsible for dorsal-ventral cell interactions during wing development.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MMSLTVLSPPQRFKRILQAMMLAVAVVYMTLLLYQSAYGYPGIQVPHSQVDALASEAVTTHRDQLLQDYVQSSTPTQPGAGAPAASPTTVIIRKDIRSFNFSDIEVSERPTATLLTELARRSRNGELLRDLSQRAVTATPQPPVTELDDIFISVKTTKNYHDTRLALIIKTWFQLARDQTWFFTDTDDHYYQEKTKGHLINTKCSQGHFRKALCCKMSAELDVFLESGKKWFCHFDDDNYVNVPRLVKLLDEYSPSVDWYLGKPSISSPLEIHLDSKNTTTNKKITFWFATGGAGFCLSRALTLKMLPIAGGGKFISIGDKIRFPDDVTMGFIIEHLLKVPLTVVDNFHSHLEPMEFIRQDTFQDQVSFSYAHMKNQWNVIKVDGFDMKTDPKRFYSLHCQLFPYFSFCPPR
The following text describes a protein:
Function:
Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18. As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP. Recruits and stabilizes RAB18 at the cis-Golgi membrane where RAB18 is most likely activated. Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum. Golgi apparatus, cis-Golgi network. Note=In neurons, it is enriched in the synaptic soluble fraction.
Sequence:
MAADSEPESEVGCPLTPLPPVSIAIRFTYVLQDWQQYFWPQQPPDIDALVGGEVGGLEFGKLPFGACEDPISELHLATTWPHLTEGIIVDNDVYSDLDPVQAPHWSVRVRKADNPQCLLGDFVTEFLKICRRKESTDEILGRSTFEEEGRVADITHALSKLTEPAPVPIHKLSVSNMVHTAKKKIRKHRGEESPLNNDVLNTILLFLFPDAASEKPLDGTTSVDNSNPAAEAGDYTLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHLWQEFVLEMRFRWENNFLIPGLASGPPDLRCCLLHQKLQMLNCCIERKKARDEGKKTSPSDSMTKAYPADAGKAGGQLGLDHLRDTEKEKGEAGKSWDSWSDSEEEFFECLSDAEDLRGNGQESTKKGGPKDMAPLKPEGRLHQHGKLTLLRNGEPLYIPVTQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMESFKAANPGCCLEDFVRWYSPRDYIEEEVTDEKGNVVLKGELSARMKIPSNMWVEAWETAKPVPARRQRRLFDDTREAEKVLHYLAMQKPADLARHLLPCVIHAAVLKVKEEESLENIPSVKKIIKQIIAHSSKVLRFPSPEDKKLEEIILQITTVEAIIARARSLKAKFGTEKCEHEEEKEDLERFVSCLLEQPEVAVTGAGRGHAGRIIHKLFVNAQRAAAVALPEEELKRSGCPEERRQTLVSDFPPPAGRELILRATVPRPAPYSKALPQRMYSVLTKEDFRLAGAFSSDTSFF
The following text describes a protein:
Function:
Required for the export of polyadenylated mRNAs from the nucleus. Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage.
Sequence:
MADREREVLEKQIRCLSNLISTHKQLSAQEQLQDRLGQQTARQLQGRRGQQTSAPVASSRHARHRYTWSAPVGSTNTHPTSACSSAVSSTRTTAAATAHKLVRQTPAAPVSAHMTVTTATTGFTSGRIVAVPVRRPSSRPAGQGSGHPSSGAKVIRSAAASQGSSQYRWTPAVTSTANAASGLVQRTAVTLTNPKTTVPPANTILKTAKTNLQKPTESGVKPPAHPVTTSVSVPSQPVSTGRVVATKYSLKKVSPAQLSLSKTSTPRAAASAGVRPSTGRVVSSRFRLRKAGTEPGSLQAHSRTVGTELGPPQAHSRAVQAAGSSGVVCSRYRLNKVSPGGTNKSGAHRVGGRGKTPSPKVLTSKHKLRRQAGRGSSMSKTSPSLSKRSPAGFVTAGKYKLRAKRGGTPGVRRGGGKSAGAVVSRYRLVKPRPAADTDRPAKDTGTAKFPSQEQLRWTRSSSSAVMAEQHRVTDTRRGRYVTPGTVSTPGLGRRVSRYKIVKSSTSAAGSMSKRTRPDPRTTRYYVKTASGKLLVKGGVVYKLSSSRLTRASHFHSHRYTLSLSQVHTFTLTGKPAAHKDVKVNIRGERFLLDASGKTLTRVKETAGSSTNEAAGTRPGKEPFTPRGVSRVVIRGVPFIRTAPGKLVRSSATNKVQEMASRAVQRSILTSQTARYRKTNRQAAARQYCMFYNRFGRCNRGNDCPYIHDPDKVAVCTRFLRGTCPVNDCPFSHKVSPDKMPVCSYFLRGVCNRDDCPYSHVYVSRNAQVCQDFVHGYCPRGKQCTKKHTLDCPDFSRTGSCPRGGRCRMVHRRRREKRRHAEAGEETRGEDADGREETAASHRPAEGDPDSGEEHQQESGEDSREESGEESGEEPPRKVAKLPSFISLRDSMDAGSTEQPGQGQEKLPAFPSQSGSQSESRARAEQVLERLQIRPRFLARPRRGGENDGTTGSAEKDGSAGE
The following text describes a protein:
Function:
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
Sequence:
MKIFWDKPIDVSLLIHEDMLFWPNDPKFQREWVAKISEGKNANLSKITLGSHTGTHIDTPYHFLDHGKTLENIDISRFYGFAKVFEIKNPNKILLQDIETLPIEEGDIILFKTKNSLLLKENIFHDDYVGLSLEAARYLADKNVKTIGIDYLSIGPRGDEGREVHRILLGKEIGIIEGLNLLEIKEGRYFMMALPLKIKGGEGSPVRAILFPIEE
The following text describes a protein:
Function:
Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.
Miscellaneous:
MISCELLANEOUS: Involved in mitochondrial-nuclear incompatibility, a major determinant in reproductive isolation between species, through hybrid incompatibility of Ccm1 and its interacting partner 15S rRNA between yeast species.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRARLLVPLVRPALVHRLDRCYSTALGSRFRKSNAVRSELKFDFPDVPVKEELFVQETPDKPLKENKTHVSDEDIDSLFDSLMSDHKAAEATEQHKELPPAEQERPSGANTHTAPIKHDTKSPMEYLAKSKLTPHVSRQVAKAMAGSPTQLLLATPASHHISTPAYQNDLWKHVISTLNTSKFQIPDFNSLMTTIPVDIRAQFLPQIEEWISQRGVKPSAITYGQVMLGYAEDGNVEKVEERFRQMIDNNITPTVHTYAHRLKACDKRGDLKQAMEIFDDLKLAQQLYGIRPNQVIFTTLISTSLRNHKVELASQIFEYMKYASLETQPTAHTYNSLITASAIRSNTERALDLFEEMKQKSVANVRTYQSLILACLRQEKYHLKAWELLLELREQHSESFYSRHTLVVVFQAAAVTGDLVFLRSLYKQLCMSPETYPDAILTQLLMQAYARYDTRTKPVASSALRATWGRLYGGNAQEMMRGFLFPDIEGMVQLNEEHPGMIPPFLPTNTIESLSFDRKKIIAESRAIFQFLKNNKPQLLDNIAATDYLKAGARHRDFPEFLRRYNEVSVGAGEAEGAVISPSEMKTYSARQKKPQRYDLQTQFSPAPRSDAHFFIALNAVQADCIADASERDPNLNHPLRRLTPQEMTDRLEFSQDVWVERGKWRKSDAYKNKYRTEAQQISADYNFALKIINALAALKQLGEAAAILSATPATFNWKKHDLAFFHNVAQAFYHEEAMKQIHKAVSRSKHLDEVIRNPDSEKSAEFDVFSI
The following text describes a protein:
Function:
Cyclic nucleotide synthase (second messenger synthase) of a CBASS antivirus system. CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection. A type I-A(GA) CBASS system; Cyclic dinucleotide synthase that catalyzes the synthesis of 3'3'-cyclic GMP-AMP (cGAMP) from GTP and ATP, and of c-di-AMP and c-di-GMP, that are second messengers for cell signal transduction.
Sequence:
MNFSEQQLINWSRPVSTTEDLKCQNAITQITAALRAKFGNRVTIFLQGSYRNNTNVRQNSDVDIVMRYDDAFYPDLQRLSESDKAIYNAQRTYSGYNFDELKADTEEALRNVFTTSVERKNKCIQVNGNSNRITADVIPCFVLKRFSTLQSVEAEGIKFYSDDNKEIISFPEQHYSNGTEKTNQTYRLYKRMVRILKVVNYRLIDDGEIADNLVSSFFIECLVYNVPNNQFISGNYTQTLRNVIVKIYEDMKNNADYTEVNRLFWLFSNRSPRTRQDALGFMQKCWNYLGYQ
The following text describes a protein:
Function:
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Subcellular Localization:
Cytoplasm, nucleoid.
Sequence:
MKKIKSFGGKSLGGGKQEKILKDFARMQEELQKKIQELEESFSQIEVEASVGGGAVRIVATCDRRVKDIEIDEDLKEDFDTLKDLLIAGMNEVMEKIEKRREEEMSKITQQFGIPGLM
The following text describes a protein:
Function:
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MLRIAVQAKGRLFEETMALLGESDIKISTTKRTLLVQSSNFPIEVLFLRDDDIPQTVATGVADLGIVGENEFMEKEEDAEIIKRLGFSKCRLSLAMPKDIEYPGLSWFNGKKIATSYPVILRNFLKKNGVNAEIHVITGSVEVSPGIGLADAIFDIVSSGSTLVSNRLKEVEVVMKSEALLIGNKNMSDEKKEVLEELLFRMNAVKTAEDKKYVLMNAPKDKLEEIIAVLPGMKSPTIMPLAQEGWCSVHTVLDEKRFWEIIGKLKGLGAEGILVLPIEKMIV
The following text describes a protein:
Function:
Involved in developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics which is essential for spore color in Streptomyces coelicolor.
Sequence:
MTRRRVAVTGIGVVAPGGIGTPQFWRLLSEGRTATRRISLFDPSGLRSQIAAECDFEPSDHGLGLATAQRCDRYVQFALVAASEAVRDANLDMNREDPWRAGATLGTAVGGTTRLEHDYVLVSERGSRWDVDDRRSEPHLERAFTPATLSSAVAEEFGVRGPVQTVSTGCTSGLDAVGYAYHAVAEGRVDVCLAGAADSPISPITMACFDAIKATSPNNDDPAHASRPFDADRNGFVMGEGAAVLVLEDLEHARARGADVYCEVSGYATFGNAYHMTGLTKEGLEMARAIDTALDMAELDGSAIDYVNAHGSGTQQNDRHETAAVKRSLGEHAYATPMSSIKSMVGHSLGAIGSIELAACVLAMAHQVVPPTANYTTPDPECDLDYVPREARERTLRHVLSVGSGFGGFQSAVVLSGSEGGLR
The following text describes a protein:
Function:
Non-functional DHOase.
Sequence:
MLLKNASFYDDEVLKRADIRLKDSLITEIKENLSPINNEEVIECRDLFVLPSFIDLSVTGLEGYENLKQKAFKGGVGLLNVFNCDQSGIKNIMAIKNNQLADIATLKNKGGEILIAPSDAFLELISHYAKSYNLPLLISLENSFEALNSGELAYELGQNFVENAFENTRLVRFMEVSRALQIPVLLDKVNSITTLKLIKAFNDLGAKLQAQTPLSHLVLDESVYEDYEPRFKIAPPLRDKESQNALKEALKNNEIAMLTSLHASKNSNAQLFEESAFGCESIEDAFSVAYTFLVQKKVISFQQLIKVMAINQAKFLKLNAGEVKENQLANLMIVDLNAQTRVSNQNSPFYGLELYGEVQRMILKGQTTFIKENACKKS
The following text describes a protein:
Function:
Plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC) thereby stabilizing SC, ensuring progression of meiotic prophase I in male and female germ cells. Promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1. Required for the localization of TEX11 and MSH4 to recombination intermediates.
Subcellular Localization:
Chromosome.
Sequence:
MAMDERRGKERVQWTTTIIISSSLKSYEIATALENRSHKVRYSDTLESGSIVFSLSGVAFLLMDAKECMTSAEEIFVTKIEKFINIHQNSFLVLFAPLHGPEEWSLMFRIHQRFLGSNLRILPVHNTVNALDLMCTIAKTTSKPHIDSICYRMITTKAYIIEQSPVWRTLQKIKLSSDSVSADSGE
The following text describes a protein:
Function:
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest and inhibits tumor growth. Plays a role in the regulation of alternative splicing (By similarity). Binds to CD44 pre-mRNA and negatively regulates the inclusion of CD44 proximal variable exons v2-v6 but has no effect on distal variable exons v7-v10 (By similarity).
Subcellular Localization:
Nucleus. Nucleus speckle. Cytoplasm. Note=Primarily nuclear but translocates to the cytoplasm following MAPK1/MAPK3-mediated phosphorylation.
Sequence:
MMSEQDLADVVQIAVEDLSPDHPVVLENHVVTDDDEPALKRQRLEINCQDPSIKSFLYSINQTICLRLDSIEAKLQALEATCKSLEEKLDLVTNKQHSPIQVPMVAGSPLGATQTCNKVRCVVPQTTVILNNDRQNAIVAKMEDPLSNRAPDSLENIISNAVPGRRQNTIVVKVPGQDDSHNEDGESGSEASDSVSNCGQPGSQNIGSNVTLITLNSEEDYPNGTWLGDENNPEMRVRCAIIPSDMLHISTNCRTAEKMALTLLDYLFHREVQAVSNLSGQGKHGKKQLDPLTIYGIRCHLFYKFGITESDWYRIKQSIDSKCRTAWRRKQRGQSLAVKSFSRRTPSSSSYSASETMMGTPPPTSELQQSQPQALHYALANAQQVQIHQIGEDGQVQVIPQGHLHIAQVPQGEQVQITQDSEGNLQIHHVGQDGQSWGLCQNPIPVSGDSVAQANPSQLWPLGGDTLDLPAGNEMIQVLQGAQLIAVASSDPAATGVDGSPLQGSDIQVQYVQLAPVSDHTAAAQTAEALQPTLQPDMQLEHGAIQIQ
The following text describes a protein:
Function:
Lies on the inner surface of the capsid shell. After binding to the host receptor, the capsid undergoes conformational changes. Capsid protein VP4 is released, capsid protein VP1 N-terminus is externalized, and together, they shape a pore in the host membrane through which the viral genome is translocated into the host cell cytoplasm. After genome has been released, the channel shrinks.
Subcellular Localization:
Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus. Virion.
Sequence:
MVTMAGNMICNVFAGLATEICSPKQGPLLDNELPLPLELAEFPNKDNNCWVAALSHYYTLCDVTNHVTKVTPTTSGIRYYLTAWQSILQTDLFNGYYPAAFAVETGLCHGPFPMQQHGYVRNATSHPYNFCLCSEPVPGEDYWHAVVKVDLSRTEARVDKWLCIDDDRMYLSGPPTRVKLASSYKIPTWIESLAQFCLQLHPVQHRRTLANSLRNEQCRGAGHSRPEGGHNNESGNNGTIVNNYYMQHYQNSVDLDGMTSQNIGGQPGSSSNPFSSILDILGTASSVALLDQDTEDVTRQPDRIVTVLDGNTSRTTQSSVGILRGYNYAPGKHTQPSSAQDTPSKAEQSVERGFTFQLAQWETSRNIWDHLTIPLPMCPGLIKVSGMYKAFIETHAYIKNGWKIQVQCNASQFHSGCLLVAMIPEYLSTAQQDFLGSWRDKTTDSTPGTWVWNTYEAFPPGFPPQQITLFPHQFLNLRTNTTVDLEVPYTNFAPSSSPTLHCPWTLVIVVVSPLQFGTGAPTQVQITTTITPTDFVANGLRQAVAQGIPGTQPYDRQFVSSEPSAPPPVYTPSWLPERSFIPGKFTDFLQVAVIPTLAEVSVQNYKPVPSFPVSNVLQTKPLVNTDLTFTSMTFRNTYVSALSLQYTQYRGSICMDLLFTGSAMCQGKFVVCYVPPGREPQSLDEAMQGTYSIWDLGLNSSFKFVVPYISASAYRFTHEDDQPSALNAVGWLQIYQLTNLTFPPNVPTRADVLVFFSAGSDFCLRFPVDTYPRTEGTENMETGAVGPSDPSETSDSHSFAMPNVVSHTNLEFLFDRYFFSGFANSCDVTANTTHTHSGDTQLNPFVTPNFKLDKTVRDYMLRAFTYFTADLGVAVQPTSVSSKPLPAVDYWVGWRPVGAPEPKLLAFSAPSPGDTVTAVKRSSVLSGGFCPIIHSVIGQGLNQVQMSIPYTTPLSAIPTSYCGYADYKKKPRLFGHPPAAHFGTLSIRVRNVDLLPEQTKKEDDPLVDLRFALFTRFRNLKAYAPRPFTRVPNSPHEQGTASRTLVRTNHITAEFVEKTPLNGLAAVFTSLSTSGYSTKLVSEPIPEATLSTILSEGATNFSLLKLAGDVELNPGPTIWSVMPGGELIEFATKVSQVYKTIKEKCTDPTTWIKAVRRLLRLLAVVSAWKHGDWFSMICLLVDLGFDLAQLSYKTFWQYLTKPFADAGLKFDFARDLTRRFRREQPRAPEVSPEEQRMAYGADFRQAVQYQENLQAPRRSWRERAQDTYRSIRRTFFDDSSSESEDGEPEVPQFRPQVYPRPRSMRVVRHPMTARRAQRVIDMGYSDYETAVENPFFISDLSSPEEEEPIPYEQARRQVPRVHFRESRGPEPTLRPRPGLMHRLAQRVHCEENQALLSEGISSTLSVLNGFFNLFKNVQWFLDFLKSCYGKLSKQLKPMQSLRDKVLQTYADSIAEFMTPSAQKKELYLQNHYDAVEAGLNSIAAAWKDLANKCYAYSRPEPVCILLKGRAGQGKSVAATVIAKAVSIVNTGKESVWTLPTDSDFFDGYAGQNVVIIDDLGQNPDGKDFRNFCQMVSSTVFLPPVADLAHKGIPFTSPVIIATTNKNENFLPVTVSDQEAVTRRYWKVIDVSADDQYKTVDGRLDYAKATQPTQIPPELAVFKTHVPLLKGALRDCQRTNRSGARVLNLYDVISAICVEVDRREQLRSNLGGIFAQSRDRHYQRDREYYDEYGTAEHRRRFVEQNPTFHFKETEADFYERVAFLSGIHGRKQSILKKIKEWFADGVRVRNLLGDAALALSLLTSILSFSLVIYSGVKTYQEFSRKHKPVRQPVYNAWEDFDEDCIFEQSRAYNIPNVRQRLRKQLAVRAENLCPSHDVTPDVEAHIPQGPVCEVDPGVPLVAQGASTGLTVNSLSLLNNVVPVTVSTVIETENGPLSQIVSECCGTYLYNKVMIMPRHILIKDWTHITAGRNSATRDQLEAVDVIDQFDMPSDAVAVKFPDKRGSSYKNIMHHLASTLPIRGKPVFILVNNNVAGRAVVHGTYIGCTQKITTLDGFTFPNVSSYKATTHLGMCGAPVIANENGNGKIIGFHCAGTGLVGYASNLTKMSANNICKVWGDPVAQGWTYFDTTHTPVHVPRKTKLRPTVAINTFECDVEPAVLSKFDRRLEEPDSFELTLLHKNDRRYPEDTSMDKHLEAAVEAYASSLFAQIGTDNGIISEYEAVTGIENLDSVETTTSPGLPYTTAGIPREALFDPDKTQLIGPAAERLQEFLRGDFSKHVFQTFLKDELRSKAKVRAGNTRVVEVAAVDHVVAGRMLLGKFTAKMHANNGLGIGSAVGCNPDVDFTRFAYQILEWDYVYDIDYKNFDASHSPKVFQYLKKLLSPENGFDVRLQKYIDSLCYSKHQFGDTYYECEGALPSGCSATSILNCLMNNIVLRAAAYDVFTNYEEGDLAFLTYGDDVLLCANQPLPLERFRKSLAKLGYTITPADKSSVFPEVSTLADVVFLKRRFKPDEEFPFLFKPVMDVRNLQDHLRYAKPGTLREKLLSTTDLAVHLGPLEYARLFRPFVEVGYCVRAFGDARRAWLRNFDL
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus; Nucleus. Cell membrane. Note=(Microbial infection) Interacts with Pseudomonas syringae HopZ1a at the plasma membrane and in the nucleus.
Domain:
The jas domain (183-205) is required for interaction with COI1 and Pseudomonas syringae HopZ1a.
Sequence:
MSSFPNTVAEGRRSGKAPEKSTFSQTCSLLSQFLKEKRASADSTLGIGGKMEPKANTKALLGSLQNSDGALKLSASAMEFLPQLVENPCIKKSRSPGPESPQLTIFYAGKMLVFDAFPPEKATEVMEMATKLASNNSGTEESPPSLPVTTEKLAVSKMPQTNTSSETPKPGNQGVGSDMRYPRRASLLKFLEKRKERVNARGPYQMNNLKPEGSSSGGEPEDQCSKQFDLNF
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
MTIAIVIGTHGWAAEQLLKTAEMLLGEQENVGWIDFVPGENAETLIEKYNAQLAKLDTSKGVLFLVDTWGGSPFNAASRIVVDKERYEVIAGVNIPMLVETFMARDDDPSFDELVALAVETGREGVKALKAKPVEKAAPAPVAAAPKAAAPAKPMGPNDYMVIGLARIDDRLIHGQVATRWTKETNVSRIIVVSDEVAADTVRKTLLTQVAPPGVTAHVVDVAKMIRVYNNPKYAGERVMLLFTNPTDVERIVEGGVKVTSVNIGGMAYRQGKTQVNNAVSVDEKDIEAFKKLNERGIELEVRKVSTDPKLKMMDLIAKVAK
The following text describes a protein:
Function:
Element of the brassinosteroid metabolic pathway that regulates typhasterol (TY), castasterone (CS) and brassinolide (BL) levels. Involved in the control of organ elongation.
Miscellaneous:
MISCELLANEOUS: The ben1-1D (bri1-5 enhanced 1-1dominant) activation-tagging mutant suppresses the bri1-5 weak mutant allele of the brassinosteroid receptor gene BRI1.
Subcellular Localization:
Cytoplasm.
Sequence:
MVREEQEEDDNNNNNNGGGERKLLVADETVPSLLDETGLVCVTGGSGFVASWLIMRLLQRGYSVRATVRTNSEGNKKDISYLTELPFASERLQIFTADLNEPESFKPAIEGCKAVFHVAHPMDPNSNETEETVTKRTVQGLMGILKSCLDAKTVKRFFYTSSAVTVFYSGGNGGGGGEVDESVWSDVEVFRNQKEKRVSSSYVVSKMAAETAALEFGGKNGLEVVTLVIPLVVGPFISSSLPSSVFISLAMLFGNYKEKYLFDTYNMVHIDDVARAMIFLLEKPVAKGRYICSSVEMKIDEVFEFLSTKFPQFQLPSIDLNKYKVEKRMGLSSKKLKSAGFEFKYGAEEIFSGAIRSCQARGFL
The following text describes a protein:
Function:
Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cell projection, phagocytic cup. Note=Recruited to Fc-gamma receptor (Fc-gamma-R) phagocytic cup. In T-cells, transiently accumulates in discrete areas at the plasma membrane of migrating cells or when membranes are deformed.
Domain:
The myosin tail domain mediates binding to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) and binds to membranous compartments. It is required for recruitment to Fc-gamma receptor (Fc-gamma-R) phagocytic cups.
Sequence:
MLAVGRMEDEEGPEYGKPDFVLLDQLTMEDFMKNLELRFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIAKYQGRELYERPPHLYAVANAAYKAMKRRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKNVLLKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPVGGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRGSEDQELQGLHLERNPAVYNFTRQGAGLNMGVHNALDSDEKSHQGVMEAMRIIGFSPDEVESIHRILAAILHLGNIEFVETEENGPQKGGLEVADEALVGYVAKLTATPRDLVLRTLLARTVASGGREVIEKSHTVAEASYARDACAKAMYQRLFEWVVNKINSIMEPRNRDPRCDGKDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGIAWQTIEYFNNATIVELVEQPHRGILAVLDEACSTAGPITDRIFLQTLDTHHRHHPHYSSRQLCPTDKTMEFGRDFQIKHYAGDVTYSVEGFIDKNRDSLFQDFKRLLYNSVDPTLRAMWPDGQQDITEVTKRPLTAGTLFKNSMVALVENLASKEPFYVRCIKPNEDKVAGRLDEAHCRHQVEYLGLLENVRVRRAGFASRQPYPRFLLRYKMTCEYTWPNHLLGSDRDAVSALLEQHGLQGDVAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQKAWRGTLARWHCRRLRAIYTIMRWFRRHKVRAHLIELQRRFQAARQPPLYGRDLVWPTPPAVLQPFQDTCRVLFSRWRARQLVKNIPPSDMIQIKAKVAAMGALQGLRQDWGCQRAWARDYLSSDTDNPTASHLFAEQLKALREKDGFGSVLFSSHVRKVNRFRKSRDRALLLTDRYLYKLEPGRQYRVMRAVPLEAVTGLSVTSGRDQLVVLHAQGYDDLVVCLHRSQPPLDNRIGELVGMLAAHCQGEGRTLEVRVSDCIPLSQRGARRLISVEPRPEQPEPDFQSSRSTFTLLWPSH
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKRKGKPAPAKAAGKKRPLAAQMKSQPKKPNPFELKGSKGHFDTMGRRSAGKKKNVIEARQEAVNRRKKTLLVEYRSLRKANTFVDRRFGEGDPEMSEADKGLGRLQRQRLKQVKLKKRGDKFTLADGAGGDGEGEELTHMGRSLADDIRNLMDKPEFDDLDEEMVEELVSQYHFGGGGEGGSDGAGGEGRGPDGKPKTRKQIMEEIIAKSKAYKALKAKQREEDEQELDKINDEFKQLVRSAALRGLLKAPGENKGVKVKAENPEDAAYDVAARELGFESKGAATEPTLTPEELLEQERQRLERLEKERIKRMRGGGGRGGDSEDEDEEDEGEDEDEEEGGRRKRRKAHQSGDALGEDDFDSDGDEGEDDEGEEEDEDEEDDEEGGGGKGVSDLDQRRMKMAAGDHPLQESFRATAAALAAKYGVQAKNPYLEDEEEEDEEGEEDEEGEEDEEGESGDEGEEEEGESGSGEGEEEDEEEGEEDEEDEEEQLQERRHPKSQPSTSKPGADAAAQQQKPQRGQQQQQKPQKPAPVLDGPLDLPYTIPLPASYNDFAALVKGRPADQLATAIARIRAFNAVALATDNKRKMQEFFGILVQHFAMVAGDSPVPVASLDVLTRVLLELLPDVPYYAATVARARLARMADQLTSSLAGLGGAGARSAADAAGTISESVAGGVAPTKAAAAAAAAAAPASPWASSRVFCQLQLFTLMFPTSDRRHPVLTPQALLVGKYLNQCVVSNAHEAAVGLLLCGLMTRIAAPAHRVTPEVLVFYRDCLAAFVPPASKAAAAAAGAADTAAAATANGAGAAGKAAGKGGKGKRKAAAPAAAATSSASAPAADADNDDAFVRFAPGSLQLSGSTAAAEEDAPPVPQLDMYAVLGTPGSDPRFATDAFKLSLMRVALCGVRRCAALASTPNPTAPGAAAAAKAAAAAAAAAEEAGEEGGGGGGVTPGTPYAGLPCFQQLFEPLTAAVAALKRIERQLPAELQELRQAVHSQLTKTTAACVAARRPLVHPGRARAAAAAAAGAGAVIPAAAVREFNPRFEEDYVSGRDYDPDRQRSEQRRLKRQVTKERRGAIRELRRDAVFMAGERDREKAALDGERLESERRFYSELQRQEADLKSGGQAGMNPHLKKKKK
The following text describes a protein:
Function:
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MVPRQPQSVKPPRRHRCPPHSRRSQSSSDPRPPARSGNQASRLPDAAIQASRLDGRSRRNRWHVKTSFTSVEDAVSSCVEAVTVHVTQKYFVGEASGQEGYTSASFHPDGLILGTGTTDAVVKIWDVKAQSNVAKFEGHVGPVTAMSFSENGYFLATAAHDGVKLWDLRKLRNFRTFSSYDLDTPTNTGTLYTSRLFYTWCNYQWTLSERTLAKGRMEESRGILREMFQCKEVTELINSVGDKIQAESLVDLLSSACDQGRIDEIDLCLEIGHQPTKALGSVAQIIFVSLDRDEASFRDHFQGMPWLAVPFDAAGLLRQKLCARFAIERIPALIPLSASVTSSSGLGCGEDAVRLVGEYGVDAYPFSAQRRELESMDDARREGGRLQELLGCEERDFVISADDIKIPIADLTGKTVGLYFGAHCCRSCHVDEQEDLMLGTFWCHCHLAPIRCYGVASLRLAYIL