lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3'. Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation.
Subcellular Localization:
Nucleus.
Sequence:
MEEDQEEPPSSSTSSESPEVVLKAPKAPTRRRKNSKKDRRQDMEVDDGEKESTAQYCKGFYDALRVMQTTNKYEFTGGAVSSPVLPVLQTAAFSPITPASASDMHTIVMSLLGNTPITSGPSIAPLSSPTLLPLVTSGDLDDLSMKILASSAIPGPPIISSSNSPDSSTTAVTTSQITAFQPLLNNFVSSTTASTSRPDKLNLTPPQQSAEIYAFNGVNSDDSDGGLDSRSASRCGMALDDQEKKKLERKRARNRQAATKCRQKKMDRIKELEEQVLHEKHRGQRLDAELLELNRALEHFRRTVEHHSGNGCPNNSIRV
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MTPWMNCLRPHSLSDSIDRLNYLITALLLLGLCIIVAAKQYFGSPIECWTPLEFKSAWEQYVESYCFGANTYTFPSEDEIEDGSERSARAASSVYQWMPIILAIQAVMFYLPHFIWILINKLTGVDVECVTSDAGKMRKLPEDQRRFVAESIATYLYDATFTNRCNDRRIFKCIEGHWCAAALYFSTKARLQIKIEFQDIFQIANIANLLLQILLITYNVGNGNLLWAFKAVNSPAFPQETLCDVAIRKHGGISRYTVQCTISINELNETIYRFLWFWFLAVLSASLVNLIYTAYHIFIASARVSACKRWLSTQQTTTEDGENLMVNRFAVSGVQPDTTLAMRFIEAEAGAIVTKEIADALFQKFTDDLSLGNDTPSTAVVHGNK
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MPWWGDFLVSLQTLGCFLCDNALPVYRRPHCEEFLQFCLRHFHVAVWSSAKEHNVMGMVNLILGESQKLLAFIWSQKWCTDTGVKCLDNKFKPLFLKELKKVWESSKPDVPWDKGEYGPWNTLLIDDSPHKVLRNPDHTAVLALPYSAMETTTSADDFLPALQGYLTKLIDVPDVRDFVRSNPIGQPLITEDSCDWEFYSKLKLSVKSSKGERWLHIESGSSSRGKGIVESTDPEMDTRQPSSSRRHGTIKRYDQPTGYLKRYGTNTEETKMDHLTRYETRKYDTDESRKYQDYETDHHQQHSRKRKRSFQQRETGKYETRKHKRIKRKHCREPERGRRDADYQSDRRERHHSSERHRYKRRRH
The following text describes a protein:
Function:
Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.
Miscellaneous:
MISCELLANEOUS: Present with 3060 molecules/cell in log phase SD medium.
Subcellular Localization:
Endosome, multivesicular body membrane; Single-pass type II membrane protein. Prevacuolar compartment membrane; Single-pass type II membrane protein. Note=From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).
Sequence:
MLHKSPSRKRFASPLHLGCILTLTVLCLIAYYFALPDYLSVGKSSSRGAMDQKSDGTFRLKSIYRHGVGANHRLHQRLEVTPEVISAAGMLYQETTTQGQDFEDQEPLWTTNAEYATTNPFDFEFELRRMPLLMKRMKERDPEFIESYIYGETYMTEEEEHAMWIDDDIVAPNITDRGTVVSLALMSSNAYVRIPQTGDWRNVTEPWNETEPEDFGWDGDGIRGHVFYNEVENIVVLSIKGTSAQGLPGSGEDETTGNDKINDNLLFSCCCARVSYLWTTVCDCYVKSYICDESCLEKELRRKDRFYSAVVDIYKGVLKEYPDAAIWVTGHSLGGALASLLGRTFGLPAVAFESPGELLPSKRLHLPFPPGLPSYMEGIWHFGHNADPIFMGTCNGASSSCSLVGYAMETACHTGRVCVYDVVNDKGWSVNMFNHRIHKVIDEVLLGYEQAAKCVEPEPCVDCYNWKFIPSRDWESSSRLITKTKSHAAPTTTTRTTATTTSSSTCVGRNWLGFCTKYEL
The following text describes a protein:
Function:
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSLHASMMSGKYSRARFTPSNVDESLFGDLKKTRDPDPVTEFDPPWVDNGKAKTKSPPKPLLFYTPNRPSSSRSSSRANSSSRSTPQRKYKPVKFTPSYVDENLFGDRNARRSNSPPPREFDPPWAKEEDNGRNNPILFDYSRKNLVFDDREVLTNRSGVSTPGSGRLRPGSTTREKSTSKPPWR
The following text describes a protein:
Function:
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.
Sequence:
MTEKSRTVNKWYAAFTKATDFDSWGQLIEAAEEYNGVAKELHKFTAVQEKMFQDDQKKLILKIALCLDLRSKTLLQTQATAGQDPMTYDDIKKVGEVLRNLIVGWHEPFPVRVEVPTRSATVDEDSPFHEEVVLAGEGGTLLPRIPYEEGFHRLTVRIDRIGLKDAESYINSYFSVHVKDSDCVVVASSQDTPVSNRKEGSYVVFGIEVEIQKHIEKFPKGTAVFFEFKHYKPKKNIISTKCFGFMEQDEIRSGPACIELYQKPTDFRRKKLNLLTSKPLYLHLTLTIHDE
The following text describes a protein:
Function:
Catalyzes the isomerization-deamination of galactosamine 6-phosphate to form tagatofuranose 6-phosphate and ammonium ion.
Miscellaneous:
MISCELLANEOUS: In contrast to E.coli strains C and EC3132, K-12 strains cannot grow on N-acetylgalactosamine and D-galactosamine, because they carry a deletion and thus lack active PTS systems specific for these compounds. Therefore, AgaS in K-12 strains is not involved in the degradation of these compounds.
Sequence:
MPENYTPAAAATGTWTEEEIRHQPRAWIRSLTNIDALRSALNNFLEPLLRKENLRIILTGAGTSAFIGDIIAPWLASHTGKNFSAVPTTDLVTNPMDYLNPAHPLLLISFGRSGNSPESVAAVELANQFVPECYHLPITCNEAGALYQNAINSDNAFALLMPAETHDRGFAMTSSITTMMASCLAVFAPETINSQTFRDVADRCQAILTSLGDFSEGVFGYAPWKRIVYLGSGGLQGAARESALKVLELTAGKLAAFYDSPTGFRHGPKSLVDDETLVVVFVSSHPYTRQYDLDLLAELRRDNQAMRVIAIAAESSDIVAAGPHIILPPSRHFIDVEQAFCFLMYAQTFALMQSLHMGNTPDTPSASGTVNRVVQGVIIHPWQA
The following text describes a protein:
Function:
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins (By similarity). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
MLAFMASDSEEEVCDERTSLMSAESPTSRSCQEGRPGPEDGESTAQWRTQESEEDCEEDPDRYACSGAPGRPSGLEEELTLKYGAKRVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEAFEAPLPGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWNTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI
The following text describes a protein:
Function:
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
Subcellular Localization:
Cytoplasm.
Domain:
The PRC barrel domain binds ribosomal protein uS19.
Sequence:
MTRPEASGPPDATRLGHLLGPHGVQGGIKLYVLGDPAQVLALKRVYVESRGWLSLRRAEGMPPNLVLYLAGVSSREGAEELRGLQVYATDAELPDLEEGTFYYHDLRGLEVYGAGGERLGTVSDVMDAGHQDLLVVDYGGGTSFVPLQAPYVEVPLAGGKPGAVHLTADAPAGLIGPEPGEEDGAAES
The following text describes a protein:
Function:
Plays an essential role in autophagy.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein.
Sequence:
MTVLGHPRSWSCHCLPVLILLLGIGHGPRVEGVTHYKPGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRSDELLGLTHTYSVRWSETSVEHRSDRRRADDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETSSGGSSDDFDQGDNGWKIIHTDVFRFPPCRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPVTTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPCAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGAVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD
The following text describes a protein:
Function:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTKFTAANMSMLLKLANSRLVLHKNKNFEQSNIHKKEIAELLTLGKEEQARVRTVAVINEDYHTEVLGILILYCESLANRVRGLEGVKICPPDLKEAVCGIIFASPYLEKQVELYKIRKRLIEKFGKKLPEECIDSCCINPKIVHRLSNKPPEESLVNYYLSNIAKKHNVEWDTPALPPLVDLQQSIPDFTLTSLAEQFPSTPSNTNPAPSSDDLLMNFPSVPKENTATIDQFPSPPSIPKSTATTQPKLEFPSLPQTMLVGPASAVNCKAFGDGLKKGYVGYESKFTIQAYDSKNTKINKGGETFNILIQGQFGDQLYGNVKDNDDGSYTASYIPPRAGGYAIAVYLENTLIADGQPFISNIEPATMMEQESKIDPTKCEAFGQGLETGVPGKLSTFTIRAKDSNGRIVKTPQQFYVFVQGPPGIQIYGDVKNNNDGTYSVTYTPTVSGGYGVMVYHETTPIREPWTFFILESQEALSKSNTEEDEMDKLWKQTATLSFTKAAVIENYPEAPIDIPTPTPSTAKVTIEESPQTKSARIEFLSSIKEKTLVVDNGSGMVKAGFAGEDAPRSIFPSIVGYPLFNSVMHGMGKDKYIGEEAQAKRGVLSIKYPVEHGVITNWNDMESLWEYTFTTELRVDPSKHPVLLTEPPLNPKANRERMVETMFEVFQVPALYIATQAVLSLYASGRTTGTVLDCGDGVCHTVPIFEGYTIPHNIKRLDIGGRDITEYLMVLLTERGYAFTTTAEREIVRDIKEKTAFICQDYYDAMAAPEDDSLITDYIMPDKQVLSIGKERFRCYEALFDPSLLGKDQNGIQHLLNDTIMGCDIDIRRELYKNIVISGGTTLAPGFESRLQKEMNFLNPSVDIKISAPPNRNLSVWCGGSVLGDLKTFSDHWITKDEYLEHGKTIVHKKCF
The following text describes a protein:
Function:
Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase; Enterostatin has a biological activity as a satiety signal.
Subcellular Localization:
Secreted.
Sequence:
MVLTLRLLLATLLIALALGAPSERGLIFNLDTGELCVQSAQCKSGCCQRDSGLSLARCSLKAAETQDCSRKSLYGVYYKCPCESGLSCDADWSIVGSITNTDYGVCYDKRDPTTSR
The following text describes a protein:
Function:
Polymerase that creates the 3'-poly(A) tail of mRNA's.
Subcellular Localization:
Nucleus.
Sequence:
MLPQYEPRQKPQTEEGPTGAELQASIELQRFIDKYDAPATEEQKTKRQEVLSKIKILINEFVRIIAKKTGNTAEGLENVESQLVPYGSYRLGVVSEGSDIDCIVVAPSFVKRSDFFNTFYEMMINHPSVKELVKVENAYSPIMSFHYDGIEIDLSFASLAMTTVAEDTDFADDHILDNVDEESVRSLNGRRVNDMLLQLVPNQDIFRVVLRFLRIWAKKRCVYGNVFGYLGGVNLAILAAFICQRYPKKSPAYIIVMFFNDLATWTWPEPIYINTPTTGNRSNWDPTRQQDHKDCMPIITPAYPTINSLHSATKSSRNRMTVEFKRGFKVASACLKSEASWERIIDSPKFFVRHRKFVEVLVVATEEKVYTEFMKFVQSRVRFLAINIETQLRHVSHAYIWPVEFPANGYRGNEFCSVFYIGLSYHVPKDENQSRTLDLTSPAKKWVDDIRQKAPPNADVILDVVDTKDLPSFLFPNGERPEVKNVKKVEQPAK
The following text describes a protein:
Function:
Not known, expressed in activated T-cell.
Sequence:
MMSAAPSPDPSLDNEWKEWKTTFAKAYSLDEERHRRLMWEENKKKIEAHNADYERGKTSFYMGLNQFSDLTPEEFRTNCCGSSMCRGEMAPDLPEYEDLGKNSYLTPGRAQPE
The following text describes a protein:
Function:
Has no inosine-5'-monophosphate dehydrogenase activity.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MVEIGMGRTARRTYELSEISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDALVSPEFAIELGRLGGLGVLNGEGLIGRHLDVEAKIAQLLEAAAADPEPSTAIRLLQELHAAPLNPDLLGAAVARIREAGVTTAVRVSPQNAQWLTPVLVAAGIDLLVIQGTIVSAERVASDGEPLNLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTQGVTTTDEVLGISVPMATAIADAAAARRDYLDETGGRYVHVLADGDIHTSGELAKAIACGADAVVLGTPLAESAEALGEGWFWPAAAAHPSLPRGALLQIAVGERPPLARVLGGPSDDPFGGLNLVGGLRRSMAKAGYCDLKEFQKVGLTVGG
The following text describes a protein:
Function:
Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein.
Sequence:
MIIKEYRIPLPMTVEEYRIAQLYMIQKKSRNETYGEGSGVEILENRPYTDGPGGSGQYTHKVYHVGMHIPSWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDAGENPDVFNLSPVEKNQLTIDFIDIVKDPVPHNEYKTEEDPKLFQSTKTQRGPLSENWIEEYKKQVFPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWYGLSMENIRELEKEAQLMLSRKMAQFNEDGEEATELVKHEAVSDQTSGEPPEPSSSNGEPLVGRGLKKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDSDESSDDEFFDAHEDLSDTEEMFPKDITKWSSNDLMDKIESPEPEDTQDGLYRQGAPEFRVASSVEQLNIIEDEVSQPLAAPPSKIHVLLLVLHGGTILDTGAGDPSSKKGDANTIANVFDTVMRVHYPSALGRLAIRLVPCPPVCSDAFALVSNLSPYSHDEGCLSSSQDHIPLAALPLLATSSPQYQEAVATVIQRANLAYGDFIKSQEGMTFNGQVCLIGDCVGGILAFDALCYSNQPVSESQSSSRRGSVVSMQDNDLLSPGILMNAAHCCGGGGGGGGGGGSSGGGGSSGGSSLESSRHLSRSNVDIPRSNGTEDPKRQLPRKRSDSSTYELDTIQQHQAFLSSLHASVLRTEPCSRHSSSSTMLDGTGALGRFDFEITDLFLFGCPLGLVLALRKTVIPALDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQRGQRSMSVAAGCWGRAMTGRLEPGAAAGPK
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 645 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Also involved in telomere length regulation and maintenance.
Miscellaneous:
MISCELLANEOUS: Present with 2780 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus. Chromosome, telomere.
Sequence:
MALFNVEGWSIKTKTVAFDNKTNKSSKDKKKNNRKNGKLTREQKLKEETEAELKEQVEDIPSEGSVAKDIPKKNQEKSDQNETSKKRKHDEEAPLMQVKENIEKPTKKQLTPLQQKMMAKLTGSRFRWINEQLYTISSDEALKLIKEQPQLFDEYHDGFRSQVQAWPENPVDVFVDQIRYRCMKPVNAPGGLPGLKDSKEIVIADMGCGEAQLALEINNFFKNYNKKAKKYLKRRHKVHSFDLKKANERITVADIRNVPLPDESCTIVVFCLALMGTNFLDFIKEAYRILAPRGELWIAEIKSRFSDGKGNEFVDALKLMGFFHKKTFDENKMFTRFEFFKPPAEIIEERRQKLERRQKFIEVETEKEELEKKRRKIAEGKWLLKPCIYKRR
The following text describes a protein:
Function:
Probable transcription factor, required for migration of the hermaphrodite-specific motor neurons (HSNs) from the tail to the gonad primordium during HSN cell differentiation. Required for phasmid neuron development. Required to specify the pi-cell fate of ventral uterine precursor cell (VU) cells; [Isoform a]: Probable transcription factor, involved in lin-12 (Notch)-dependent anchor cell (AC) and ventral uterine (VU) precursor cell fate specification and in AC invasion. Prevents AC proliferation after AC cell specification by repressing lin-12 expression. May form a positive feedback loop, together with the transcription factor fos-1, that maintains mutual high levels of expression and so activates AC invasion; [Isoform b]: Dispensable for anchor cell (AC) invasion and for preventing AC proliferation.
Subcellular Localization:
Nucleus.
Domain:
The positive regulatory (PR) domain is required for egl-43 protein stability but is dispensable for anchor cell (AC) invasion and preventing AC proliferation; The C2H2-type zinc-finger domains 1, 2 and 3 are dispensable for anchor cell (AC) invasion and preventing AC proliferation; The C2H2-type zinc-finger domains 4 and 5 may be required for anchor cell (AC) invasion and preventing AC proliferation.
Sequence:
MSIDTDFLTSVEVKEDELHGNVLIAVTQIALGRTIGVIDKATPNDSNALLILNLIKEADDGEDANICMRQEDRKTFLQTSKIINIGERLLLQRLSEEECDEEDQDDLENLILLKDEDRPDSTQSCTKSSSEDSNLNGFEEYIREHGELVPGQTPPDGSHKCGVCPKSFSSASGLKQHSHIHCSLKPFRCHLCPKSYTQFSNLCRHRRVHSDGWTCPTCQSQMPSQAALTKHRPVCEMTALYKPLMAQLAGLSGAGGLGSVPYWPHILQMATQAPHFPLAFLAANPEAYKLMQQTTCASPDAECSSGHASESSPTTTEPVDLTATPKPPSTSEMETTSKSDDGEDRDSIGDSGNDDDDDSEAGVLDESSTTTSTKKRPTSHTISDILAAPQLGAQALNSTFLGMLQRSLNYNPAVPSPHSFLRAMSGAKASSSPSSSSGSGKDRYTCKFCQKVFPRSANLTRHLRTHTGEQPYKCQYCERSFSISSNLQRHVRNIHNKPNTSLTPHNHHRQRSLHNSTSTSTTTTTVHHPLLHLPGTSVPVPKV
The following text describes a protein:
Function:
Deaminates adenosines to inosines in tRNA-Arg(ACG). Exclusively involved in A-to-I editing of the prokaryote-type chloroplast-tRNA and not involved in C-to-U editing.
Miscellaneous:
MISCELLANEOUS: Since the absence of A-to-I editing is compatible with plant survival, a limited two out of three codon recognition occurs in chloroplasts, although this mechanism is less efficient than wobble pairing.
Subcellular Localization:
Plastid, chloroplast.
Domain:
The C-terminus (843-1307) is sufficient for the deamination.
Sequence:
MFNTYTNSLQWPIRSRNQQDYCSLLPERSESYKLSKAYTSSRCYCVSSRSSCCCCCSTPSSSSFVKPKVLINPGFVLYGVRQSTLIQWPSFQRRLLVGGGRLMGCEVYSSCDGIRRKNRSFKLRCLEESDECCGGRSCSDDVEAMISFLSEELIDEERKWNLVSRVKEKKKVGNVRKVSVEGSNSYGNGRVSQRVKKPEGFGRRKEIKEDVKLNERYDCEHCGRRKKSSELESESRRGSKLVTGEYIGKSYRGDEEREVRPRRRKSSSCSSYYSLASSGEFESDTEDQEEDVEIYRENVRSSEKKVVDQSAKRLKSRKEASQMHSRKKRDESSTGVDSRYQKQIFEEGENSNQAVTLNQRRRKKFSQTENRVSESTGNYEEDMEIHEVHVNDAETSSQNQKLFNEREDYRVHSIRNDSGNENIESSQHQLKERLETRYSSEDRVSEMRRRTKYSSSQEEGINVLQNFPEVTNNQQPLVEERISKQAGTRRTTEHISESSEIHDIDIRNTYVSQREDQIRNQEVHAGLVSGLQSERKQQDYHIEHNPLQTTQSDRTSVSVSHTSDAVRYTEIQRKSEKRLIGQGSTTAVQSDSKVEKNGAQKEDSRLDHANSKKDGQTTLGLQSYQSKLSEEASSSQSSLMASRTKLQLVDLVSEEMQGSETTLIPPSSQLVSRRSGQSYRTGGVSIQEISHGTSESGYTTAFEHPRAGASVNSQSAGELMGFTSHEDAMGSAHRLEQASEKYVGEFVKKAKHGVINPETEEQRAESNQLKRRDSRRSSGGSGAKGPSDEMWVTDSAQGTPHPGATEGNAAVGNAIFKRNGRSLWNVIADIARLRWGSRAGSPDSSAKPAGRSSPNESVSSATWFSGREHDGSSDDNTKGDKVLPQEAPSLHQVEVGQTSPRSQSEYPGTTKLKQRSERHEGVVSSPSSTILEGGSVSNRMSSTSGNQIVGVDEEEGGNFEFRLPETALTEVPMKLPSRNLIRSPPIKESSESSLTEASSDQNFTVGEGRRYPRMDAGQNPLLFPGRNLRSPAVMEPPVPRPRMVSGSSSLREQVEQQQPLSAKSQEETGSVSADSALIQRKLQRNKQVVRDSFEEWEEAYKVEAERRTVDEIFMREALVEAKKAADTWEVPVGAVLVHDGKIIARGYNLVEELRDSTAHAEMICIREGSKALRSWRLADTTLYVTLEPCPMCAGAILQARVNTLVWGAPNKLLGADGSWIRLFPGGEGNGSEASEKPPPPVHPFHPKMTIRRGVLESECAQTMQQFFQLRRKKKDKNSDPPTPTDHHHHHLPKLLNKMHQVLPFFCL
The following text describes a protein:
Function:
Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P).
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum.
Sequence:
MAAPKASVAAGGLSSAANSGTNLLFSSSATEFNFTVPFIPVSQAPAPPPPPPPGLLPSDDATDVGEEDSFLGQTSANPNPPPTFNYFSQVPSSSDPFGSIGQSPLGVTSPPQSGMSVFSKPPVSLPLLPGSQDGPSTFSAALSKSQSFNTPPTSLQGIGSYQMSQQSGPPAAGFSTPPHGTSQQSYNPYRHTTISSRANPYITPPQLQQSQPPTQSIQPSPPVPPTQMYSTPPGSLPPSTLPPQASMSAGALVKAPPNFLQNQYEPLQPHWFYCKEVENKELWMPFSLLDSAALEEVYNSVQPDPENVLLSTDGGRYDVYLYDRVRKAVYWEEEQSEVRRCTWFYKGDTDSRFIPYTEDFSEKLEVEYKKAVTTNQWHRRLEFPGGETIVMHNPKVIVQFQPSAMPDEWGTTQDGQTRPRVVKRGIDEDHEEIPDGEVSQVDHLVFMVHGIGPVCDLRFRSIVECVDDFRTVSLKLLQTHFRKSLEEHKVNRIEFLPVHWHSALHGDATGVDRNIKKITLPTIGRLRHFTNETLLDILFYNSPTYCQTIVDKVGLEMNRLYALFMSRNPDFKGAVSVAGHSLGSLVLFDMLSNQKDWTSTVNSVAPVAPNGIVKDVAEQQMTVDSNPAGSIPSLSNDDHGDHDVEDDIPTLQRTLEMLSLSEYISTFENEKIDAESLLMCTIDDLKEMGIPLGPRKKIANFVKDRAAKQEQKKAALEKKAAMDALIRNQEEAAQATKKVARLAASSAMVMPQDPSKRRLSVGTSVSSAHIDYEYFEVGTGQVSVVYTTLDFEPEIFFALGSPIGIFLTVRGVERIDENYRFPTCKGFFNIYHPLDPVAYRLEPMIIPDLDIKPVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNDFARAHTSSIQLQAELEKVANQIKEEEEKHETEAEKIVESPDFSKDEDLSIKIGLLNGGRRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTALLLLKEIYRTMNIYPEQPQH
The following text describes a protein:
Function:
Nucleotidyltransferase that catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs, which is necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair (By similarity). Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs (By similarity). While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded (By similarity). The structural flexibility of RNA controls the choice between CCA versus CCACCA addition: following the first CCA addition cycle, nucleotide-binding to the active site triggers a clockwise screw motion, producing torque on the RNA (By similarity). This ejects stable RNAs, whereas unstable RNAs are refolded while bound to the enzyme and subjected to a second CCA catalytic cycle (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 13500 molecules/cell in log phase SD medium; MISCELLANEOUS: [Isoform Cytoplasmic+nuclear 1]: Produced by alternative initiation at Met-10 of isoform Mitochondrial; MISCELLANEOUS: [Isoform Cytoplasmic+nuclear 2]: Produced by alternative initiation at Met-18 of isoform Mitochondrial.
Subcellular Localization:
[Isoform Mitochondrial]: Mitochondrion; [Isoform Cytoplasmic+nuclear 1]: Cytoplasm. Nucleus; [Isoform Cytoplasmic+nuclear 2]: Cytoplasm. Nucleus.
Sequence:
MLRSTISLLMNSAAQKTMTNSNFVLNAPKITLTKVEQNICNLLNDYTDLYNQKYHNKPEPLTLRITGGWVRDKLLGQGSHDLDIAINVMSGEQFATGLNEYLQQHYAKYGAKPHNIHKIDKNPEKSKHLETATTKLFGVEVDFVNLRSEKYTELSRIPKVCFGTPEEDALRRDATLNALFYNIHKGEVEDFTKRGLQDLKDGVLRTPLPAKQTFLDDPLRVLRLIRFASRFNFTIDPEVMAEMGDPQINVAFNSKISRERVGVEMEKILVGPTPLLALQLIQRAHLENVIFFWHNDSSVVKFNEENCQDMDKINHVYNDNILNSHLKSFIELYPMFLEKLPILREKIGRSPGFQQNFILSAILSPMANLQIIGNPKKKINNLVSVTESIVKEGLKLSKNDAAVIAKTVDSICSYEEILAKFADRSQLKKSEIGIFLRNFNGEWETAHFASLSDAFLKIPKLETKKIELLFQNYNEFYSYIFDNNLNNCHELKPIVDGKQMAKLLQMKPGPWLGKINNEAIRWQFDNPTGTDQELITHLKAILPKYL
The following text describes a protein:
Function:
Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling.
Subcellular Localization:
Cell junction, focal adhesion. Cytoplasm, cytoskeleton.
Sequence:
MSACNTFTEHVWKPGECKNCFKPKSLHRPPESASECKTNINAKLTNSQRSTSSSRAGQVRPPVAKKPTIAVKPTMMLPCSPPGLDSEGNVPRLAEGPQVTKSSPFTVWNHNSLNSLRPAGTNNNQGEDLVGQTEAYSAISLQPTSSNNNGLTDVLKEIAGLGSSPSTSRNDFFGRICSSYRRSLERGLPAASCLHAGSSGRGAMKRVSLSDSTEVISTEGGRFCYPEFSSDGDDEEEDSDEDDDGEHDSWDESDEELLAMGIRMRGQPRFANFRAATLSPVPFALVKKWNTVPLRNRSLQRFCAVDYDDSYDEILNGYPSVDSNGAPALLSYTSDHQGSGFLSTSESTTSPESLASLPEETCTESSRDTDDHRNGLPFPPNKETSSRGPSSPKSNETHKAVLAIRLEEQDDSQREGGALPQALPGQPITISFSPTEEQAKPYRVVNLEKAPICKPYTVVDVSASMATKDNTHLSEITPKSSVTVDPCPVSPISPQSPRSPMSPVTSPSISLSPLMPQSPIGSSSGLSGFRTKPGSIRYQEVWTSCTSPRQKIPKVDLTSGSADPRLINHKSAPTSPTAAFGSARTVPTKSPNLSEIKFNSYNNAGMPPFPIIIRDEPAYARSSKKAVKVPIVINPSAYDNLAVYKSFLGLNGELPHSKPGAGERVASHTYEEIGSSESSQPSPSEQKPPPISADLTATGELRTTTVNDGKYRTTTGVAFHAGIQSTNPAFLAHSSLDRIRNPSSEQPPEGSKDCQLASSGSSGQREKASAVLSQIVSSIQPPVSPPESPAGQSKTCSAEELYSLPPDASRDTTVNRPKSLHCSAEPHKETPHKLLPKSQSASAAVPPTSPKSETSAPFPPVRSSSSPYHSSNLLQRHFNWTRPAGAKSTDGETSPGAEGRRSSDGNKPKRWISFKSFFRRRKDEDEQKEKMEREKEKGKLLGLDGTVITVLPPPPLQRQQWFSESKTDDPLQKPTIIFTYKSESATGGEEAELRVEEHKESVTAEGGASSLSTPPKSRASLLISKVMNQLPVQETEISSATSLPAKLELSPLREPPASCPPPASPTSNSSRQADPEEEGIAHTISRSPESNSCRATYTNLGQSRANMIPVKHPRHPKASDDTLTSDPEVSELTNKSTPPPLPKKLVPRAQIDSSAAGKELAPRPKGEARPGGTSLSVANPLYDLESTWDTASQSSSLSSEARHHDESGDSLECPVGGRSLSCLTSSTSMQGCDRRGYRSTESLTARTRGPGRLTKGQKQMPYRGMESWEEVVGRIRGLHTDTLRKLATRCEDRFMAGQKDHLRFGTDSWSHFRLTAGKPCCEAGDAVYYTASFAKEPLMNYAVKICRGVVKETQQQFFHSLAVRQSIAVHFNIQQDCGHFLADVPARLLPWEQKEDKDERGGTEGGEDEKEDAAGPGGKLCSCVVVITREVPFQTVADFVREGVERHARNPELYERQVCLLLLQLCAGLEHMKPYHVTHCDLRLENLLLVHCQPGNPWNLELLEPNNNAASGSSTAAASACPARLIISNFSQAKLKNVVLEPASFRDHSRLAPELLTATQYRKCDEFQTGILIYEMLHRPNPFEDSPELKEREYCSSDLPQLPLRSLYSNGLQQLATLLLNPNPSERIQMADARACLQCLLWGPREDLFNSLNPGAGTVQRHTVLQNWLDLKRTLMMIKFAERSLESGCGVSLEDWLCCQYLAFSTTESLSRVIKILQQPQGVLI
The following text describes a protein:
Function:
P37 is part of a high-affinity transport system.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MLKKLKNFILFSSIFSPIAFAISCSNTGVVKQEDVSVSQGQWDKSITFGVSEAWLNKKKGGEKVNKEVINTFLENFKKEFNKLKNANDKTKNFDDVDFKVTPIQDFTVLLNNLSTDNPELDFGINASGKLVEFLKNNPGIITPALETTTNSFVFDKEKDKFYVDGTDSDPLVKIAKEINKIFVETPYASWTDENHKWNGNVYQSVYDPTVQANFYRGMIWIKGNDETLAKIKKAWNDKDWNTFRNFGILHGKDNSFSKFKLEETILKNHFQNKFTTLNEDRSAHPNAYKQKSADTLGTLDDFHIAFSEEGSFAWTHNKSATKPFETKANEKMEALIVTNPIPYDVGVFRKSVNQLEQNLIVQTFINLAKNKQDTYGPLLGYNGYKKIDNFQKEIVEVYEKAIK