lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential for pollen development. Involved in protein N-glycosylation in the endoplasmic reticulum (ER), especially in the female gametophyte. Mediates pollen tube (PT) reception in synergids through protein glycosylation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKTTATSFVTGERVVVFVVVSRILLSLPLSLISHGFSLFLLSLSAFLVEIRVETSPFLLSHFSSRRGASSGILLGAVTLPSVMISKLVQLSRAISIHEAEQDELAHVTMQYWAASASCCAILIYLSVIMSQVRKDESLSSSSIWLTRVSLTGTVLYGVACFVSLSMISHTGLNTSLKMLWMLFHGLAAVKLIRHLLCTFPSCASIGEALLVTSGLVLYFGDFLACTIAKIFEKLIPVDLVSISYGIKRTETGIIVQGLLLGLLLFPMVFRFVLHIYESSLRKRDARQRNCSDAAKSVLFFVSLLFFMVVAVPSWMQFVHDFNQHPFLWVLTFVFSEPLKRLSLCIYWILLIVVSVSRFYNISRSSKVERILLRKYYHLMAVLMFLPALVLQPKFLDLAFGAALAVFVALEIIRIWRIQPLGEPLHQFMNAFTDHRDSEHLIVSHFSLLLGCALPIWMSSGFNDRALSPFAGILSLGIGDTMASMVGHKYGVLRWSKTGKKTVEGTAAGITSMMAVCFVLVPILASMGYILSQGWWSLLVAVTATGMLEAYTAQLDNAFIPLVFYSLLCL
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MDRWFKKSRAQCQNRKVKTKIKVDLRSTHEDSETAFTSRTLSETFFRKARNHGRSLSIARAVYRVHNISVCEGYLDDQFTQLQKLQDESNPDFVAELVSLFLKTPKSFLTILQLLYKFVFYNRSETFSQGMLDAHDLFPIMIFLLTKKVNRRLWIISRLILMFISSRVAVPA
The following text describes a protein:
Function:
Monooxygenase that mediates oxidation of dimethyl sulfide, the first step in dimethyl sulfide degradation pathway. Has much lower activity with diethyl sulfide and other short-chain alkyl methyl sulfides.
Miscellaneous:
MISCELLANEOUS: DmoB has not been identified yet. Only a peptide from the protein encoded by a putative flavin reductase (AC E0XCR3) was obtained by mass spectrometry, which is insufficient for linking this gene to DmoB.
Sequence:
MKKRIVLNAFDMTCVSHQSAGTWRHPSSQAARYNDLEYWTNMAMELERGCFDCLFIADVVGVYDVYRGSAEMALRDADQVPVNDPFGAISAMAAVTEHVGFGVTAAITFEQPYLLARRLSTLDHLTKGRVAWNVVSSYLNSAALNIGMDQQLAHDERYEMADEYMEVMYKLWEGSWEDDAVKRDKKSGVFTDGSKVHPINHQGKYYKVPGFHICEPSPQRTPVIFQAGASGRGSKFAASNAEGMFILTTSVEQARQITTDIRNQAEAAGRSRDSIKIFMLLTVITGDSDEAAEAKYQEYLSYANPEGMLALYGGWTGIDFAKLDPDEPLQAMENDSLRTTLESLTHGENAKKWTVRDVIRERCIGGLGPVLVGGPQKVADELERWVDEGGVDGFNLAYAVTPGSVTDFIDYIVPELRKRGRAQDSYKPGSLRRKLIGTNDGRVESTHPAAQYRDAYVGKESVADRTQPSPFANAKAPVAE
The following text describes a protein:
Function:
This protein is one of the chains of the nonenzymatic membrane component (F0) of mitochondrial ATPase.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MLEGAKSIGAGAATIALAGAAVGIGNVLSSSIHSVARNPSLAKQLFGYAILGFALTEAIALFAPMMAFLISFVFR
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MICRTCLRRASGFARPAAAAATRPMVAASSRAAFSTTFSVCTPPAATPAAAAPATSTAEAGLAPVPGAATTEQAKAAISSCPAGTKLNGLNYFKNKADPVALPDEEYPEWLWRCLEVQKKTDDAADADAGDEFSKSKKQRRLAMKRARAQEAKILASGDLEALAPKIPLQKQSVNLPGAVNGGVQDAVLADEKREELRKAMRKERKAKIKESNYLKAM
The following text describes a protein:
Function:
Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).
Subcellular Localization:
Mitochondrion.
Sequence:
MAFFTGLWGPFTCVSRVLSHHCFSTTGSLSAIQKMTRVRVVDNSALGNSPYHRAPRCIHVYKKNGVGKVGDQILLAIKGQKKKALIVGHCMPGPRMTPRFDSNNVVLIEDNGNPVGTRIKTPIPTSLRKREGEYSKVLAIAQNFV
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds to GA-rich elements (GAGA-repeats) present in regulatory sequences of genes involved in developmental processes.
Subcellular Localization:
Nucleus.
Sequence:
MDFGGQRGGARHKCDRFREHSPWSMMAYQHEVKEQTALIMNRNLVNMIAERDAAIEEMKRALLEKKRAFEEREIAISQRNFAYRERDEAIMERNNAYALQNCILSSGVECDNNYVPQEINALSESNNKSPQPKKTKERKPREKRTCDELKVKKEWDGKKMGLNRVDYDDSVMPSPGCSCTGVFRQCYKWGNGGWQSACCTTTVSVYPLPPVPNKRYARIGGRKMSASAFSKLLSELAMEGFDLSVPVDLKNRWSKHGTNRYITIK
The following text describes a protein:
Function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
Sequence:
MGTHVIKMPDIGEGIAEVELVEWHVQVGDSVNEDQVLAEVMTDKATVEIPSPVAGRILALGGQPGQVMAVGGELIRLEVEGAGNLAESPAAATPAAPVAATPEKPKEAPVAAPKAAAEAPRALRDSEAPRQRRQPGERPLASPAVRQRARDLGIELQFVQGSGPAGRVLHEDLDAYLTQDGSVARSGGAAQGYAERHDEQAVPVIGLRRKIAQKMQDAKRRIPHFSYVEEIDVTDLEALRAHLNQKWGGQRGKLTLLPFLVRAMVVALRDFPQLNARYDDEAEVVTRYGAVHVGIATQSDNGLMVPVLRHAESRDLWGNASEVARLAEAARSGKAQRQELSGSTITLSSLGVLGGIVSTPVINHPEVAIVGVNRIVERPMVVGGNIVVRKMMNLSSSFDHRVVDGMDAAAFIQAVRGLLEHPATLFLE
The following text describes a protein:
Function:
Head completion protein that closes the capsid once the viral DNA has been packaged. Probably part of the head-tail connector by binding to the portal protein and to the tail completion protein.
Subcellular Localization:
Virion. Note=Minor protein of the capsid.
Sequence:
MQIITAEDYRLYGGLKRPELESGVEVMITAANALITSLLGMDDADAVDQLITTKPTRKKYFLSSPSATSVTKMTINDKEIDPEQYKLYSDGVILLKFNPPEGYMDVEYTQGGFNPMPEDLKLAACMLVDHWHKQDYRQARTIGGETVTFNNTKSGIPEHIRTIIEVYRRV
The following text describes a protein:
Function:
First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.
Subcellular Localization:
Nucleus.
Sequence:
MDIKGLLETNDVREEHTFSSEAETVPDTPAKHNPSKRKRSEEKPAASSNTAVMSAATKRPSASLRFEPSFLGTTKMSGLVRVIGNFLQHYLLNDTVGVMEIEAKVGNIIDPQTNKRLVLPVLSECVLNPEFAPSVNFRSDMTQSEHKHYNDFLNTAFVNAQRPGRAPMKYKHTKEIDKFFEKASHGKVRVSRNVADNTLMACIEKRRIADLFVYCPNNHFDFRISISDEIPVPLPKDESKPSFSREKDRVGYVHQDIHIDLTQTYQKNARSGTTSKRHELEVEFGNTPKLREYAESARNGSPLAWERVLNLFVENIRILLLQTA
The following text describes a protein:
Function:
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
Sequence:
MAPSIFIKNLPLKSPVVYAPLAGFSDFPYRRMSAEYRPALMFCEMVKMEGLHYCPQRTLRLLDFAESMRPIGGQLCGSRPDLAGESAKILEGLGFDLIDLNCGCPTDRITKDGSGSGMLKTSELIGKVVEKMVEVVSVPVTVKIRSGWDFDHINVEETVRIIKESGASAVFVHGRTRSQGYQGPSNLEFISRAKQAAGNDFPVFGNGDVFSPEAAKTMLETTHCDGVLVARGTMGAPWIGKQIEDYLTTGTYSSPSFSTRKQAFVQHLQWIEEYYQSEEKLLTDTRKLCGHYLILSPKVRSLRANLAKASSSQEVYQLIDGFEEPTEEEELLSE
The following text describes a protein:
Function:
Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Secreted, cell wall.
Sequence:
MFPIGRKGNSQDKGRKRPLLRSHLLPIGTSRDLPDAANTASTGMATATAPSAVASDLSSSMFVRKAVPLRYGTAPNTGVSSVHRSNTVPAHAVSSRAPSVHPDKERSKSAEMAAAVAGIRPTPPPGRRLLPVPAHTPAPVRSHSRVQPQTPRIDFLPQKNPLRRAATDTWDTRTSTQLSTMRSSSFGSVQRTEDDEDNDNDNSNDNDDDGEDSDTTPQPTPIANKYLNTAVPLGDVATAVAPNKNANSNPGFDIKFSSPTFDPKNSSTEKDVEKGEGGEDDADGNESTDDKNEVEMASRTANIHSAQPTFSSNPEYLWELEDFQKRRDERNNNARHLIRKTEDEKRHAERRNKLLLVICCVLAAVLIGITVGMTSTIHRLERSNQKQGLVNQNKQHNDTQRTDGGMLPIGIDTLTDAAKLASILSDTSLHNVLYGIGYSPQNVMTSQCGVNQTEVTLDVAALSRVTKRIRLYGTSCDQALYVLRAIDSLKVDMKVTLGVWINGNPVVCAAQIAEAITAAEQFPHLIESIMVGNEVFFRGELAPAKLVGYMHEVRTELQLRNLTIPVGTSELGSQWSPYMASNVDILGANIHPFFGGLEVSEATTWTLNFLESFVVNEITEAEKIPQIVISEIGWPSGGGQHGAAKSGVAQQQRLLQDWVCTAKDLPQIGWYWFEAFDEPWKRVFDTPTEKWESQWGILTPDRRLKKGLSLKISCN
The following text describes a protein:
Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Domain:
Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
Sequence:
MAKFRVFFFLAVLLFASSFLLQVARCQSDSESDADADLVAETVEEGRVSGAVGDDSQNFEGWNFSPASGVETVCVFPKNPSKLVVAGEETEVLIGMKNEGEQSVKVLAIHASIHLPYHHMLVQNLSAMSFNNASVPASVQATFPYTFAVSKYLQAGTFDLVGMIVYEVDQLPYQNIFYNGTIEVTEAGGLVSVETLFLISLGFALFVLFGLWVRGQMQNLSKKTKKVAKVEIGTKTVDASMDEWLQGTAYTQSNKSKKKK
The following text describes a protein:
Function:
Catalyzes the reductive conversion of 2-oxoglutarate plus glutamine to two molecules of glutamate, using reduced ferredoxin as the electron donor. Contains one FMN but no FAD. The FMN-binding domain is also involved in the delivery of sulfite to the reaction center of SQD1.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MALQSAPKLLYSSPSPSVFSANERRVAFSDFVGLSKKRSRRRRIAGTFRNFPALSAVSSAIKAVVDVDRAHHSTDSGSPTVSTSSHPLDQQVVNLEDILAERGACGVGFIANLDNKGSFQIVKDALTALGCMEHRGGCGSDNDSGDGSGVMTAIPWDLFNDWGKDQGIGPFDRSHTGVGMVFLPKDDLLAEEAKKVVLDTFAQEGIEVIGWRSVPTNVSVVGRNAKETMPNIQQVFVRIIKEDSTDDIERELYICRKLIERAASSHTWASELYFCSLSNQTIIYKGMLRSEVLGMFYYDLQNERYTSPFAIYHRRYSTNTSPRWPLAQPMRFLGHNGEINTIQGNLNWMRSREPSIQSPVWRGRENEIRPYGNPKASDSANLDSAAELLIRSGRTPEEALMILVPEAYKNHPTLMIKYPEAVDFYDYYKGQMETWDGPALLLFSDGKTVGACLDRNGLRPARYWRTVDNVVYVASEVGVLPMDESKVTMKGRLGPGMMISVDLSSGQVYENTEVKKRVASSNPYGKWVKENLRSLKAVNFLSRALLENDTILRNQQAFGYSSEDVQMVIESMASQGKEPTFCMGDDIPLAVMSQKPHMLYDYFKQRFAQVTNPAIDPLREGLVMSLEVNIGKRGNILEVGPENASQVILPSPVLNEGELEALVNDPLLKAQMLPIFFDIRKGVEGTLEKRLNRLCEAADEAVRNGSQMLVLSDRSEELEPTRPAIPILLAVGAVHQHLIQNGLRMYTSIVVDTAQCFSTHQFACLIGYGASAICPYLALETCRQWRLSNKTVNLMRTGKIPTVTIEQAQKNFCKAVKSGLLKILSKMGISLLSSYCGAQIFEIYGLGKDVVDIAFQGSVSKMGGLTLDELARETLSFWVKAFSEDTAKRLENFGFIQFRPGGEYHVNNPEMSKLLHKAVRNKSESAYAVYQQHLANRPVSVLRDLLEFKSDRAPISVGKVEPATSIVERFCTGGMSLGAISRETHEAIAIAMNRLGGKSNSGEGGEDPIRWRPLTDVVDGYSSTLPHLKGLQNGDTATSAIKQVASGRFGVTPTFLVNADQIEIKIAQGAKPGEGGQLPGKKVSAYIARLRNSKPGVPLISPPPHHDIYSIEDLAQLIYDLHQINPKEKVSVKLVAEAGIGTVASGVAKGNADIIQVSGHDGGTGASPISSIKHAGGPWELGLSETHQTLISNGLRERVILRVDGGLKCGVDVMMAAAMGADEYGFGSLAMIATGCVMARICHTNNCPVGVASQREELRARFPGVPGDLVNFFLYVAEEVRGILAQLGFEKLDDIIGRTDILKPRDISLMKTQHLDLSYILASAGLPTMSSTAIRKQEVHTNGPVLDDQILSDPEIIDAIENEKIVNKTVKIFNVDRAVCGRIAGVIAKKYGDTGFAGQLNLTFEGSAGQSFAVFLTPGMNIRLVGESNDYVGKGMAGGELIVTPAENPGFRPEDATIVGNTCLYGATGGQIFVRGKAGERFAVRNSLAEAVVEGTGDHCCEYMTGGCVVILGKVGRNVAAGMTGGLAYILDEDDTLIPKVNKEIVKIQRVTAPVGQMQLKNLIEAHVEKTGSSKGASILKDWDKYLPLFWQLVPPSEEDTPEASAMFEQMTSEGASLQSA
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSNAKERKHAKKMRNQPTNVTLSSGFVADRGVKHHSGGEKPFQAQKQEPHPGTSRQRQTRVNPHSLPDPEVNEQSSSKGMFRKKGGWKAGPEGTSQEIPKYITASTFAQARAAEISAMLKAVTQKSSNSLVFQTLPRHMRRRAMSHNVKRLPRRLQEIAQKEAEKAVHQKKEHSKNKCHKARRCHMNRTLEFNRRQKKNIWLETHIWHAKRFHMVKKWGYCLGERPTVKSHRACYRAMTNRCLLQDLSYYCCLELKGKEEEILKALSGMCNIDTGLTFAAVHCLSGKRQGSLVLYRVNKYPREMLGPVTFIWKSQRTPGDPSESRQLWIWLHPTLKQDILEEIKAACQCVEPIKSAVCIADPLPTPSQEKSQTELPDEKIGKKRKRKDDGENAKPIKKIIGDGTRDPCLPYSWISPTTGIIISDLTMEMNRFRLIGPLSHSILTEAIKAASVHTVGEDTEETPHRWWIETCKKPDSVSLHCRQEAIFELLGGITSPAEIPAGTILGLTVGDPRINLPQKKSKALPNPEKCQDNEKVRQLLLEGVPVECTHSFIWNQDICKSVTENKISDQDLNRMRSELLVPGSQLILGPHESKIPILLIQQPGKVTGEDRLGWGSGWDVLLPKGWGMAFWIPFIYRGVRVGGLKESAVHSQYKRSPNVPGDFPDCPAGMLFAEEQAKNLLEKYKRRPPAKRPNYVKLGTLAPFCCPWEQLTQDWESRVQAYEEPSVASSPNGKESDLRRSEVPCAPMPKKTHQPSDEVGTSIEHPREAEEVMDAGCQESAGPERITDQEASENHVAATGSHLCVLRSRKLLKQLSAWCGPSSEDSRGGRRAPGRGQQGLTREACLSILGHFPRALVWVSLSLLSKGSPEPHTMICVPAKEDFLQLHEDWHYCGPQESKHSDPFRSKILKQKEKKKREKRQKPGRASSDGPAGEEPVAGQEALTLGLWSGPLPRVTLHCSRTLLGFVTQGDFSMAVGCGEALGFVSLTGLLDMLSSQPAAQRGLVLLRPPASLQYRFARIAIEV
The following text describes a protein:
Function:
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic.
Sequence:
MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHWYPEKPYKGSGFRCIHVGEKVDPVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQIGEKGPVKVLYVDDSSETGCELDKEIKNSFNPEAQVFMPISDPASSVSSSPSPPFGHSAAVSPTFMPRSTQPLTFTTATFAATKFGSTKMKNSGRSSKVARTSPINLGLTVNVNDLLKQKAISSSVHSLYGLGLGSQQQPQPQPQQQQQQQPSSSQPPPPLPQQQQQQPQQQQQQQQQTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAYGGLNEKSFVDGLNFSLNNMQYSNQQFQPVMAN
The following text describes a protein:
Function:
MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Preferentially localizes to membrane rafts.
Sequence:
MPGNREEFDIEKVLKSKKLEAIETSTEKKAPYTVFESTDKLLLIIVLSLVGFWSAISSPIYFPALPTLTKYFNTTPSVMNISVVAYLIFQGIAPTISSNLADTFGRRPVILGSIIVFCAVCIAISQTNVYWLLALLRCFQAAGIAPVFAISSGVAGDICTPANRGGMVGAVSGLQLAGNGIGGLVGAALISGFHTWRAIFIFLAIGGGVTFIFAFLVLAETSRRIVGNGSIRPKNVLNKAVLIYLPHFKNKITNDYSTLQPKGPFDILGPFKIFFQKEVFCTLLPSGMHFAAWTVSLTSLSTELESAKYNYSVMKVGLVYLPQGIACFIGSLIAGRCLNWYYRYRKNLYDKQMNDVPLNDRPPFNLVASRLTLTIVPLAMMVIGLSAFGWCLEYKKPIISIIISTILISFSASVMMSICTTMLVDLYPKQSGASASCVNLMRCWLAALFTGVLDKIISALGLGGTYTLLTGICLLTDLGLVYVLYTANQRFVNYVSPNQTAVNSDAEDY
The following text describes a protein:
Function:
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MADMQNLVERLEKAVGRLEAVSHSSGMHGGCGDSSPKGGLAPYVEVFDSLLAGPAADYLKISKEIGGDVQKHAEMVHTGLKMERSLLVTASQCQQPDGNKLSSLLAPISEQIQEVQAFREKNRGSKLFNHLSAVSESIPALGWVAVAPKPGPYVKEMHDAAMFYTNRVLKEFKDVNKKHVDWVKAYLAIWTELQAYIKEYHTTGLAWNKTGPTAKELSATSSGPSAPPPPPPGPPPPPVPTSSSCDESASRSALFAQINQGEGITHALKHVSDDMKTHKNPALKNQSGPVRSGPKPFTAPKPAGGATPKPVTKKEPPVLELEGKKWRVENQENVSNLVINDTELKQVAYIYKCVNSTLHIRGKINSITLDNCKKLGLVFDDVVGIVEIINSRDIKVQVMGKVPTISINKTDGCHIYLSKNSLDCEIVSAKSSEMNVLIPTESGDFNEFPVPEQFKTLWNGQKLVTTVTEIAG
The following text describes a protein:
Function:
Transcriptional repressor which acts as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. The physiological relevance of these observations is unsure.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol. Note=Predominantly localizes to the nucleus, where it co-localizes with CLOCK. At the G1/S boundary, partially translocated to the cytosol.
Sequence:
MEKNQKCATEQERFKARSGHGDGQRAEPRKTQTTTESDKDSGYSDVASECLSSVEQTDTEEGPTTSRWNVALKPSGKTPSQPQSLVVLKNLLVDQGSGPEPNASSWAVHPSIQLLQTSPQIVFFPPTVSSSKPSTCRKDTKYLPILKSYTKIAPHPSHRVSNISLPCARKRGPDERPHNQTKRQCSKGHSGSRKGMDAATLLDTGVQQGPVDQNVKESSVSAKNKELDMQLTTQNINSNEKGSRVASLDTQQNLLSAGQQNKSQRFQNTLDILHRSGLLSIAMKTKELARHNQATQSQLEKLQEQVQLYATAMSSNNPHDWQRLQDSLAEVVKGDTEDLSVREMDL
The following text describes a protein:
Function:
DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor). May function as part of an mSin3A repressor complex. Has no intrinsic transcriptional activity. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B. Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor.
Subcellular Localization:
Nucleus.
Sequence:
MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPLRVGAIVETRTSDGSFQEAVISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETLDQLPLTNPEHFGTPVIAKKMNRGRRSSLPVNEDEKEEESSEEEDEDKRRLNDELLGKVVSVVSTSEKSEWYPALVISPSCNDDITVKKDQCLIRSFIDSKFYSIARKDIKEVDILNLPESELSAKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENEEEKEKEAKKEEEEMPEEEPDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDSIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTIHHHEPKVKEEKKDLEESMEEAPKVDQEMPLVEVKSEPEENIDSNSESEREEVELKSPRGRRRIARDANSIKKEIEEEKTEDKLRENDTENKDVDDDSETAEKKENELLLGRKNTPKQKEKKIRKQEDSDKDSEEEEEKSQEREETESKCDSEGEEDEEDTEPCLTGTKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSDGKSGTRSARSNRPDSSPLSNGMEDSCSSDSETEDLLEKNLMNEELSPDIKEELEKNENLNDDKLDEENPKTAPHILKENDRTQMQSLETLKLEAGENEQIVQILGNKVEQEEVKKDAEKSPKGKGRRSKTKDLSLEIIKISSFTQDEAGTEPHIDAQSPEFSSLDSKNFSSATEDETDQCAKEKKLKRKILGQSSPEKRIRIENGMEMTNSISSTSQERTSDCTASEGVKNLNFEQHFEIENEGMPSLIAEPNQCVQELTNEKFDGPAEETVNTPLKEEEDAMPLIGPETLVCHEVDLDDLDEKEKTSIEDAVVESSESNSLVSIPPALPPVAQHNFSVASPLTLSQDESRSIKSESDITIEVDSIAEESQEGLCERESANGFEASVASGTCSIIVQERESREKGQKRPSDGTSGLLAKKQKRTPKRTSAVAKNEKNGAGQSSDSEDLPVLDNSSKCTPVKHLSVSKPQKLARSPARISPHIKDGEKDKQKEKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR
The following text describes a protein:
Function:
Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
Sequence:
MSDSVILRSIKKFGEENDGFESDKSYNNDEKSRLQDEKKGDGVRVGFFQLFRFSSSTDILLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIKFATYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLHMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEALSKIQHGHTIISIAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFNAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGAIQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPLKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLIPNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSVQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIRNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSPIS
The following text describes a protein:
Function:
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MEVQTECVEPPAVPQCDPQPTGKINKAAFKLFGKRSTGSGMASFFSFRNKGATSTELVRSKTHDGLTGSNNDTDGQKGDALAALEAGPVRSLSKSLSFFSFLRRGSFRSGENGGVGIVRRGRGLKGFFSSMRWRRKEKTSEGETEDVDSKNEKVGGIAESEKVKSITLTLEPPPHPHQNDCEDAEEKPNLQAADTPTTSVVTPLHCEAMPGPSGAPDSPFTYTPTDSPLRPPVQKAKASISSLTPSLATPPLDRCSAGDPPSEPSVDRLCSLLFTDVTSLKSFDSLTGCGDIIADAEEEGPVGNGAPLSLPARNKAPPPPQQHPAGSGVVAYMGGGEEMASPEGVDDADMQGLWHMLPSVGDDSPALPRVHQLSSTNPTSTCSSRANPTFLSSGPGCSDRKAPQVKTLGLSKIPVVGAVGSRSAKPPLPYTHGRHPTSPGEKEPLSDEGYWDTPSATPTATPDESGLQRNQKLTLSRDSCSGDHLYDLYNDPEEGKDEVGSTSLPRESKIPVSTRQTSPPHSVSQSALSSVLGADSTPRPQANPPTRTRIPVSKVPVRRSGNKTDTTGGNARKK
The following text describes a protein:
Function:
Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo (By similarity). Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer (By similarity). The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB (By similarity). Plays a role in the maintenance of retinal neuroepithelium organization, structural integrity, adhesion, photoreceptor polarity and retinal photoreceptor layer thickness (By similarity). May play a role in determining the length of cone photoreceptor outer segments and proliferation of late-born progenitor cells (By similarity). Also required for maintenance of the apical polarity complex during development of the cortex (By similarity). Inhibits gamma-secretase-dependent cleavage of APP and secretion of amyloid-beta peptide 40 and amyloid-beta peptide 42, and thereby inhibits gamma-secretase-dependent Notch transcription.
Subcellular Localization:
[Isoform 1]: Apical cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell junction. Note=O-glucosylation is required for localization at the apical plasma membrane (By similarity). Distributed in a complex anisotropic pattern on apical cell edges: the level of CRB2 on a cell edge is inversely correlated with the level of MYH10/myosin-IIB (By similarity); [Isoform 2]: Secreted.
Sequence:
MALARPGTPDPQALASVLLLLLWAPALSLLAGTVPSEPPSACASDPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQNTTFSVMAGSPIQASVPAGGPLGLALRFRTTLPAGTLATRNDTKESLELALVAATLQATLWSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLWHEGCPARLCVASGPVALASTASATPLPAGISSAQLGDATFAGCLQDVRVDGHLLLPEDLGENVLLGCERREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEIPAATFGLGGAPSSASFLLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEVPGSPAVVLPGRWDDGLRHLVMLSFGPDQLQDLGQHVHVGGRLLAADSQPWGGPFRGCLQDLRLDGCHLPFFPLPLDNSSQPSELGGRQSWNLTAGCVSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLWCPGQPCLPPATCEEVPDGFVCVAEATFREGPPAAFSGHNASSGRLLGGLSLAFRTRDSEAWLLRAAAGALEGVWLAVRNGSLAGGVRGGHGLPGAVLPIPGPRVADGAWHRVRLAMERPAATTSRWLLWLDGAATPVALRGLASDLGFLQGPGAVRILLAENFTGCLGRVALGGLPLPLARPRPGAAPGAREHFASWPGTPAPILGCRGAPVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLPLPLPFPLLEVAVPAACACLLLLLLGLLSGILAARKRRQSEGTYSPSQQEVAGARLEMDSVLKVPPEERLI
The following text describes a protein:
Function:
Potent antifungal and antibacterial activity against Gram-positive bacteria.
Subcellular Localization:
Secreted.
Sequence:
MQLNLGAIFLALLGVMATATSVLAEPHRHQGPIFDTRPSPFNPNQPRPGPIY