lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAGSQLKQLKAALKANGLIGQTNIKKKNKKSKTPSETRRNDKQEILSNIRKDFNLFDGKINRTKRDVTMIQGGKFVKVGSKQHSDATRAKSDVENSMKLQYELDKKQHGKTGGLVDRRFGENNRNLTAEEKMLERFTRERQGTSKKKINFALGSDDEQDDEDNDGFVLTHSGKSLSLDNDLDDSKSNTKYYDEDSLMPEEVQPKRKSKQEVMKEVIAKSKFYKHQRQMEFQKAQDEIMNLDDEFGDIMTEFNNNPAKKPQSFSNKTPEEIEYDNKVRELTYDRRSVPADRTKTADELQKEHDTRLQKLEADRLRRMNGDYDDREAEADDLEGFWNGSEDEEEGFAIDNSAEEEGSSSGNEDDMDQSKPSGRTLKKTIIQIPGTHEDFIASLSSVDESNHCNYIKKVIETYQPRLAEGNKERMNVFVGILFKHILHLANDPCPPAENINETMKILKKLSESYNEKLVEVIRVEINDIQERIFNLQPRDLVYFVMVGYLFSTSDHYHLVVTPTLILMNESISSIPYDKKTTVSRIGQGLFIVDILLNYQTFSKRFTPEIVCFLEKAALLLIPEPEKLTNQSLSINKIIKSDTNLRTKGIKPTEDLVKVSELFGNDSQVLKLKLTNKLIDIFARILSIWRDNEVMIEILSSFSNLANHLSIHYNSPKLNQLIEKMSKIQNNLIKERKPLTLQHHKAISIATFAPKFEENFNPDKKSYDVNRERQELNKIKNQIKKERKSTLKDIRKESKFTARQQIADKKDKYDEYHKKMANIVNSISTIEGAEKNTYEREKQRRKNK
The following text describes a protein:
Function:
Catalyzes the exchange of ADP and ATP across the membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEHGPMHPSVSQKIHWQPDLPVRHFNYTPRMQNIHVDGALVNRKSSSIVTPLPPAFAGAPLENLKDPVLIDLAATGIVRTAVAPFERVKLLMQNQNGMIRSGRLPQPYNGIFDCFARTIRKEGILSLWRGNIAIATAYVSSKAIHYKSYEYFASRIDSSWSIFEVVAAGGFSTAANLFLVYPLVYAGTRMANDVKTANDVKTAGYSSKRQFNGILDVYRKTLKVDGISGLFRGYTMALAQVGVITALSALLRPWYQYLSIQSQNNDLGKAILDCVFDCSGSLASYPLGTVSRRMMMTSGEAVKYKSSRNAFAQIFKTEGVESFYKGAGADILVSVAFKGYALLLSHLYAAYFAAMANGGDGGRPGFALSIKWKKDGVK
The following text describes a protein:
Function:
Nucleoside transport protein that can transport adenosine, uridine, thymidine, cytidine and deoxycytidine. Shows weak activity with inosine and xanthosine. Transport is driven by a proton motive force. Does not transport guanosine, deoxyguanosine, hypoxanthine or uracil. Also shows activity with the chemotherapeutic drugs 3'-azido-3'-deoxythymidine (AZT), 2',3'- dideoxycytidine (ddC) and 2'-deoxy-2',2'-difluorocytidine (gemcitabine).
Miscellaneous:
MISCELLANEOUS: Binding of nucleosides to NupC requires the presence of hydroxyl groups at the C-3' position of ribose.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDRVLHFVLALAVVAILALLVSSDRKKIRIRYVIQLLVIEVLLAWFFLNSDVGLGFVKGFSEMFEKLLGFANEGTNFVFGSMNDQGLAFFFLKVLCPIVFISALIGILQHIRVLPVIIRAIGFLLSKVNGMGKLESFNAVSSLILGQSENFIAYKDILGKISRNRMYTMAATAMSTVSMSIVGAYMTMLEPKYVVAALVLNMFSTFIVLSLINPYRVDASEENIQMSNLHEGQSFFEMLGEYILAGFKVAIIVAAMLIGFIALIAALNALFATVTGWFGYSISFQGILGYIFYPIAWVMGVPSSEALQVGSIMATKLVSNEFVAMMDLQKIASTLSPRAEGIISVFLVSFANFSSIGIIAGAVKGLNEEQGNVVSRFGLKLVYGSTLVSVLSASIAALVL
The following text describes a protein:
Function:
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
Sequence:
MPFWYSNSKLIWLLSPFSLLFWLISQLRRALFSLGLKSSYRAPKPVIIVGNLSVGGNGKTPVVVWLMEELKKRGLRVGVISRGYGSKSKTYPLFVTKNTNPIEGGDEPVLIAKRTNAPVVISPNRQQAIELLLSQAECDIIISDDGLQHYQLQRDLEIVVMDAERALGNGFVLPAGPLRELPSRLKSVDFVITNGGKNQYSDAVMRLVPHFAINLKTNEKRQLNEFQSGVAIAGIGNPQRFFTMLEKLGIQLKQTQAFQDHQHFEASQLEKLAENQPLFMTEKDAVKCQSFAKDNWWYVPVDAEIIEAEKQRENLPHFWAKIDKLVEQYRNG
The following text describes a protein:
Function:
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
Sequence:
MIIRKKSLSGIPHEKGKLNEKKLQNITIKNYEITNDESKKAFFDYYSCIYPFNMPISLYKYPPIFGYCSLSDFQEIGAKRLALLQFLDTCTISGDDEKDQYTNLRKTDKNYSLNNTTDNKNKIIRQKIYEYKFGIQSMKDYNKEEMENIIMTDLLSHYILRIAFSKDKEKQQWFLKQELKLFTFRLNELKNINVLNSQNISESERGLVHLLKRENIHYESITKPSISYGNKNDEWEKYTEFIPNKDTIQKLFKVPFYPDAYFLVRDHKVVVEKGVAYVPDIYLDIILTVQFKLNIKESFKYLDHNEKMLLKIQNDPRISTFLSSLPKAYVAKDFRQNYEHTQDTRLSPQNLYSVYKQSFPPCMRRIFVNYIKDKHLKHWGRQQLWLFLKGAGMTLDENIQTNRSIWLQPDKFDKEHRYNIRYMYGKEGKKTDFSPYNCSKIINNFPVPSSNDIHGCPFKNFDESHLKSLLYFFGLSDEQIKSIMPLKRNNEYQMACVKFFMETHPGSVGDGVGNHPNSYYVESRKYYKSKTSGSEKIIN
The following text describes a protein:
Function:
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
Subcellular Localization:
Chromosome. Nucleus speckle.
Sequence:
MVFVLKVPRRKVVVRCPQMEPEGESHRGAGFQWRSYKLLLDPALHSRRTTQKVYRYDGIHFNISDGAFLPLGDVRDPRQHRMWSKPREISLPVPKFKFDEFYVGQLPQKEITFAHLNDNVREPFLADMCRKFGDVEEVEILLHPKTRKHLGLAKVLFSSSKAARDTVTHLHNTSVMGNIIHAELDLRGQQRQKYYDLIVNGSYNPQTVPTSGRWAQERLQPDMVDSRRRLSSDSSSYLPNNGTPSSQDLGSSYSQYTPSSSQGTPYTPRSGTPFSQDSAYSSRQGTPSHSSSQDTSGYKSRRQENSSGDSYSRRSGHHYSPAPSSSTSSSSSQHESSQKRFHRHQNRSSPQSSYRSRHRKPPPPPEEPPLIRFPGTPPLPPPPPPPPPPDDIHTDRDYRIAHPPPLPPSIPAPSTTILVPPPPPTEGWEPPPPPLPPLPPVCSPPPSPARSCSPLLDGVSESLPFTQHSSSLDSRIEALLKEQRSKFSFLPSDTEEEEEATTEAPTQEPVVVEEVPPVHGPYTPPLPASFEDVSAEAILRMAEIGRTANGQDRGMLMQEPPFLRDPSSWSRNSLPPQLLSSGEDMEISDEEINMEMPGAAVPPFPLLPHLPGAAGTFQSQPIPSPLLPLPPHHPQPPSPFPLLPNTAARGRLGDLAAGSSTPPALDPSSSSSASSAPHIYDFVNSMELVNRLGNQWGGTSMSFQMQTQMLSRLQQNRQGKNMPFEDPYPPPLLPHPIPPRLHQPHPPPPLMPEQVFNPTFPPFPAQQPQPLLPPREFTARTARGPSQEPRGPGWAPGGGVDPHASTIESVLSALIQEMKNTMQRDLNRKMVENVAFRAFDEWWERKEEKAKPFQNVAKPPPREEDKEKARPKEPGLLSLVDWAKSGGAEGFGFGSGLREALRLPSFKVKRKQPSEDEDSEQKRPRPSTPAEEEQDEREKETESDSRQGGKLPQQEGKRVHKRRRPFHLDSEGEEASEESASDKDDEEDELSEKGEDSEEEVSPLTKLSSKIISDDDSDSSSESDSSSSSSSSSSSSSSASSSASTPASSDDEEEQEETPDLLSVSEPPRPPSPASPLPELEAAADKKEPLDIPPATEVKEEQSTEIPEPPLPPPPEPPSKPHAPPSPPLQLLPPPKKRRKTVSFQLLPEEEAEAADSKPPNHHVPENAAPERPISPLLEPMHLLPTPTDKAPLPSPEAPTAPTAELHSSPKPEPEEPPLPAKEASPRKQPPERLTVLNLPWDHASLVKPYPPRVRSEDNMEEEAEEDFEKHLEEEEVKPPPPIEAPTQPEPKSPLISEPSEVERTEFIEDLLFAPVRQILLEHSYASIPAALKQPPRKQRLSVELEKPNELVHVDLGQAVLEAPEEVVCIGGGLAVDGETGLLDVGDLDISSPRKMEEALAKLVHDEPKIKSKRTLAKEAEPGEVTSEEEDEEEMWVTTRQLRSHRNRKAAQRQLPPLYEIRSEFEQMTILYDIWNTGLDFEDMVFLRDTYERLLQEDHSTDWLNDTHWVHHPITNIADPKRRKNRQDGLREHQTGCARSEGYYAISKKDKDKYLKVLLVAAEEQEADTQGTNRVLSERRSEQRRLLSAMGSTALLDSDLLKLNQLKFRKKKLRFGRSHIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYSQQGIGSSYLFRMDQDTIIDATKCGNLARFINHCCSPNCYAKVITIESQKKIVIYSKQPIGINEEITYDYKFPLEDNKIPCLCGTENCRGTLN
The following text describes a protein:
Function:
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Sequence:
MNRIEQQFKKSPAYVAYLTAGDGGLERSLESLLALAKGGVNILEVGVPFSDPVADGPVIQEASIRALAQGTTLHDVLTLITSFRQHSEIPIILFTYFNPLLAAGDKIYQQMKSAGVDGCLVVDLPVEEAAPHLTACKTAKIAPILLISPSTTQERLKKINEHGEGMLYYVCRPGTTGVRATLPENFPAKMNQIKSMTSLPIVTGFGIANRKMAAQALQYADGFVIGSLFVKAIAEGISKNALTRLAQSLNPHYPNLRLITPFRKKTF
The following text describes a protein:
Function:
Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins (By similarity).
Subcellular Localization:
Periplasm.
Sequence:
MRNLILTAMLAMASLFGMAAQADDYTAGKEYVELSSPVPVSQPGKIEVVELFWYGCPHCYAFEPTIVPWSEKLPADVHFVRLPALFGGIWNVHGQMFLTLESMGVEHDVHNAVFEAIHKEHKKLATPEEMADFLAGKGVDKEKFLSTYNSFAIKGQMEKAKKLAMAYQVTGVPTMVVNGKYRFDIGSAGGPEETLKLADYLIEKERAAAKK
The following text describes a protein:
Function:
May be involved in cell wall biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MPRVLEAATIVLFLFFLAVVWFQQEKIKFFISRNERSNHSAASDASSSRANFYNLLPAREDHGKCKSRFEQHRYGKRDWEYVPSEYLIDRLRSYEEFHARCTRGNSQTWFNSSTATENNDCKFILWLDNSGLGNKMVSIAATFLYALLTRRVLLIDPAEDMEALFCEPFPRSSWFAPRDVPLEFLRSDEFRISFDKCHPGTAKFARHAYIEIMNGYDSIGDKFFCEKQQQNISDQFPWLTITTNLYFVPSLYYVPSFRTELDKLFPRQEAAVFQHLVKYLFHPSNAAWDRATRFYDTYMAGSSKLVGVQMRVLPNFQDLSRRAQSFSDAMVQCLLQSKLLPDVSVASNSSASGKIIGVVVASLDGQYFDGLREIYVSSPTVDGSLVRVFAPSKERWQQTNDRNHDEKALADMLLLSFCAELVTSPGSTFGYAAQGLGGVKPWLLNEKNCSKLDSTEPCFHAKVFYGCNCDSSSEAKSVQNNARSCPDVPWGLQTSPFQKTGS
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MASAAAEDLRRRQRAEREATLLCIDVCSQPYISVERMRELHQHYDNIVEERLADERCGYPICPHRLASEAVESAYFGSVHIDQKHGRIVDITESMRYCSRECYAASRHYRRQLLDSAVGLRSEAELRNLRNISVLLPSDLMDPDALVARLSAVQILSPHPAPSGSARVAPIRDVQEHVAGASTPQPGAKAELSTTTATTTPGQPANKGAGHQSASTSSAPSRSNRPETWTEADIWAEYEDAMRDLAEQERAQVRARAAAEAEAAVAAAAKATGSTTPSNTSTTLADSQEQTSKSLATSSDSNSESKAEREHGLTRVARLLRELAALQPYAGALANEANGLTERFILPTLDTNQRQRRLEILSALLNDALPAEGLVLDAAERLLLGAVLLRLCEQGADIPVTLVAKLEPN
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATP synthases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a/ATP6 in the membrane. The K/ATP19 chain binds the dimeric form by interacting with the G/ATP20 and E/TIM11 chains.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Note=The F-type ATP synthase complex is anchored in the mitochondrial inner membrane via the F(0) domain with the F(1) domain and the peripheral stalk extending into the mitochondrial matrix.
Sequence:
MGAAYHILGKTVYPHQLAIGTIVSVVGGIVIASSGKKAEKPAAPAIQAGSSDEEKFIANFLKEQEAAEKK
The following text describes a protein:
Function:
Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC. In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVSAELSQTIINNQVTSVLILDESLMIRYANPAAEQLFSQSAKRLMHQSLNHLVQHSSLDLQLLTQPLQSGQSITDSDVTLVIDSKPLMLEVTVSPISWHKELLLLAEMRTIGQQRRLTQELNQHAQQQAAKLLVRGLAHEIKNPLGGLRGAAQLLERMLPDPALMEYTQIIIEQADRLRGLVDRLLGPQRPGEKKWENLHLILEKVRQLVELEAGANLVFERDYDPSLPNILMDTDQIEQALLNIVSNAAQILTNQTHGVITLRTRTVHQANIHGQRHKLVASIEIIDNGPGIPPELQDTLFYPMVSGREGGTGLGLSISQNLIDQHQGKIEVQSWPGRTVFTIYLPILNCC
The following text describes a protein:
Function:
K(+) channel that conducts outward and inward rectifying currents at depolarized and hyperpolarized membrane potentials, respectively. The outward rectifying currents are voltage-dependent, coupled to K(+) electrochemical gradient across the membrane, whereas the inward currents can be induced in response to activation of Ca(2+)-mobilizing receptors. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. In trigeminal ganglia sensory neurons, the heterodimers of KCNK18/TRESK and KCNK2/TREK-1 or KCNK10/TREK-2 inhibit neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). In thymocytes, conducts K(+) currents upon T cell receptor (TCR) signaling leading to sustained Ca(2+) influx and NF-kappa-B activation, FOXP3 transcription and positive selection of regulatory T cell (Treg) progenitor subsets. Appears to mediate the analgesics effects of hydroxy-alpha-sanshool, a metabolite naturally present in Schezuan pepper and other Xanthoxylum plants (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Each subunit contributes two pore-forming domains 1 and 2 which assemble to form a single pore with M2 and M4 transmembrane helices lining the central cavity and M1 and M3 facing the lipid bilayer. The transmembrane helices are bridged by the selectivity filters 1 and 2 carrying a signature sequence TxTTxGYGD that coordinate the permeant ions. Up to four ions can simultaneously occupy the selectivity filter and at least two elementary charges must translocate across the filter to convert it into the open conformation.
Sequence:
MEVSGHPQARRCCPEALGKLFPGLCFLCFLVTYALVGAVVFSAIEDGQVLVAADDGEFEKFLEELCRILNCSETVVEDRKQDLQGHLQKVKPQWFNRTTHWSFLSSLFFCCTVFSTVGYGYIYPVTRLGKYLCMLYALFGIPLMFLVLTDTGDILATILSTSYNRFRKFPFFTRPLLSKWCPKSLFKKKPDPKPADEAVPQIIISAEELPGPKLGTCPSRPSCSMELFERSHALEKQNTLQLPPQAMERSNSCPELVLGRLSYSIISNLDEVGQQVERLDIPLPIIALIVFAYISCAAAILPFWETQLDFENAFYFCFVTLTTIGFGDTVLEHPNFFLFFSIYIIVGMEIVFIAFKLVQNRLIDIYKNVMLFFAKGKFYHLVKK
The following text describes a protein:
Function:
Palmitoyl acyltransferase.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MYVVPPPQRSDSGSNGDLRVYQTWKGSNIFFLQGRFVFGPDVRSLALTICLIAVPVTIFCIFVARKLIDDFSDSWGVSIVAVAVVFTIYDLILLLLTSGRDPGIIPRNAHPPEPETLDGNMDAGAGQTPQLRLPRIKEVQLNGITFKVKYCDTCMLYRPPRCSHCSICNNCVERFDHHCPWVGQCIGMRNYRFFFMFVFSTTLLCIYVFAFCWVYIRKIMESEHTTTWKAMLKTPASIVLIIYTFISMWFVGGLTVFHLYLISTNQTTYENFRYRYDRRSNPHNKGVVNNFKETFFSTIPPSKNDFRAMVQREPPLPPRSVAGGFMSPNMGKANDEIEMGRKAVWADMGPAMSDHGDGKHGNNERLHVKDGELGELSPDIRATVDEQSDRPSMHPRRSSWGRKSGSWDMSPEVMALAARVGEQNQNGGGSSSGSGLVTENRPT
The following text describes a protein:
Function:
Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Plays a role in controlling the timing of seam cell development during the larval stages. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promote the aerobic catabolism of fatty acids for reproductive growth. May be involved in thermotolerance.
Miscellaneous:
MISCELLANEOUS: [Isoform b]: Produced by alternative initiation at Met-60 of isoform a; MISCELLANEOUS: [Isoform c]: Produced by alternative initiation at Met-487 of isoform a; MISCELLANEOUS: [Isoform d]: Produced by alternative splicing.
Subcellular Localization:
Nucleus. Note=Diffuse expression during mitosis. Increased nuclear accumulation upon infection by E.coli.
Sequence:
MGTNGGVIAEQSMEIETNENPDKVEEPVVRRKRVTRRRHRRIHSKNNCLTPPNSDDDPQMSTPDDPVIHSPPSIGAAPGMNGYHGSGVKLEESSGACGSPDDGLLDSSEESRRRQKTCRVCGDHATGYNFNVITCESCKAFFRRNALRPKEFKCPYSEDCEINSVSRRFCQKCRLRKCFTVGMKKEWILNEEQLRRRKNSRLNNTGTCNKRSQPGNQQSPQGPNQQPHLSPHHPGVAIYPPQPQRPLTINPMDNQMMHHMQANRPNAMPQLISPPGAQPYPLTSPVGSSASDSPPNRSLTMMHNGEKSPDGYDPNIMAHRAPPPSFNNRPKMDSGQVVLSTEEYKQLLSRIPGAQVPGLMNEEEPINKRAAYNCNGHPMPAETTPPYSAPMSDMSLSRHNSTSSGTEKNHMTHSTVSAIPGNSAQNHFDIASFGMGIVTATGGGDAAEEMYKRMNMFYENCIQSALDSPENQEPKPQEAMIPKEEYMTPTHGFQYQSDPYQVPPAERNINYQLNAAELKALDAVREAFYGMDDPMEQGRQMQSFLKANKTPADIMNIMDVTMRRFVKVAKGVPAFREVSQEGKFSLLKGGMIEMLTVRGVTRYDASTNSFKTPTIKGQNVSVNVDDMFAKLNANAQAQKAKCLEFFGFFDEEIKKNELAVYLVMLAVLFSVRSDPPMNENDVRIVTERHNHFMSLLNRYLESLFGEQARRIFERIPKALGLLNEIARNAGMLFMGTVRSGEAEELPGEFFKIK
The following text describes a protein:
Function:
May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Domain:
Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
Sequence:
MDDMENKIHPSFSDLVETALDFEYPGGPLELSKVTSEDDFVKPYTGHHFTFRIPYSGTFVEWEILFDPENPTQPPDFVCADDINCDPDSYCQMMQFWDLQSPDCLAKLVSQLIHIYKEYQISQILGFGKAAETYHSLVTAGVLVENIEACYLSRERKFNFLIKLNVNDEDLPVVKGLGSILVYAGLLFSLGMDGKILTHSLVISPYLERLLGSQLLDQLQSTSSFSQNIDALVLNDFSLSLYRILKKVRENHKRRRDTVSTLLGLYPTNVVFYDEELYSHIILLFKLDDARYVTHLELNDEAKFIFFAMDCPVKIAKEETIPYTETETLSFAHKPSTAEFSKYLHKTLSSKLKLFVNRALKSVTPA
The following text describes a protein:
Function:
Formylates methionyl-tRNA in mitochondria and the cytoplasm. Responsible for the formylation of the N-terminally formylated (Nt-formylated) mitochondrial matrix proteins that are encoded by mitochondrial DNA. Nt-formylated proteins in the cytoplasm are strongly up-regulated in stationary phase or upon starvation for specific amino acids and are targeted for degradation by an E3 ubiquitin ligase-mediated fMet/N-end rule pathway. Increased Nt-formylation of cytosolic proteins appears to be important for adaptation to these stresses.
Subcellular Localization:
Mitochondrion. Mitochondrion matrix. Cytoplasm.
Sequence:
MAPKIPLNVIFLGTDEFSIPILRKLIGCVQRVRVVSAGGKRQSRRGEIPLPPAAMEANANGLEYIKLQDGWKNFHMRPDDQLAITASFGRFVPFKILNQLPYGGINIHPSLLPKYRGAGPVYSTILNGDRLAGVTIQTMDSKQFDKGKSLAQAYLKLNGKETYTLLTKILSLGAAGMLEHVLLQSLYLPNCQTNTVAPQIHGRITDTGGLQLISKETFPSFQESWAKKITPEDAHVNFESMNTQQIYNMSRAFNHVWCILNNKKVFLYDVHPLHSTSAEDWIHMKPGEFALLEKNLLLVKTLDHVMVIKGGIRLSARKIVDPVEWGKTFNSGRGGRFQYV
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MAPKAEKKPAAEKSPAVEKSKAGKKLPKDVGGSAAAADKKKKKSKKSVETYKIYIFKVLKQVHPDIGISSKAMGIMNSFINDIFEKLAQESSKLARYNKKPTITSREIQTAVRLVLPGELAKHAVSEEKKPAEKTPVAEKAPAEKKPKAGKKLPKDAAAVLKQVHPDIGISSKAMGIMNSFINDIFEKLAQEASRLARYNKKPTITSREIQTAVRLVLPGELAKHAVSEGTKALGDSPIIYLQSFGNAWGSLFTVGLTIPPQLMFRSVME
The following text describes a protein:
Function:
May play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity. Abundant expression accelerates the exit when cells are in M-phase and also delays the entry into mitosis when cells are in G2. Phosphorylates prp2 in vitro and so may have a role in co-ordinating pre-mRNA splicing with the progression of the cell division cycle.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Enriched in the nucleus in mitotically arrested mutant and wild-type mitotic cells but cytoplasmic enriched in cells at other cell-cycle stages.
Sequence:
MGSDGSSLSPKVSQPGHTEIVDHVSEKVITNGKNVNKKVNAEVDGKSMVEKVKTHEENAEDYHYGGYHPVYIGEEFHHRRYVVERKLGWGHFSTVWLAYDRAAKRRVALKVVRSAEHYRETSIDEIRILQKIREGDEKHLGKKHIISLLDYFVHRGPNGAHVCMVFEVLGENLLSLIQSYGHRGVPVGIVKQIAYQLLIALDYLHRECGIIHTDLKPENVLICIDQDALQHIEAPATTSSPTSNTSSSKTRNNTGYTAKAPIIKRGQSVDNSAQERKTFAKNPTKNSKPAGQVIPSSPFTSTLSRFPSLEGAVSEISLRDSQKHNSHPNSPFSSGDNSLILDGVNGSQEPVPKITVKIADLGNACWTRKHFTNDVQTRQYRSPEVILGCRWGASADCWSFACIIFELLTGDYLFDPRNGNSYSKEDDHIAQIIELLVNYPKQMALSGKHSRDLFNRRGELRNIHKLKFWPLKDVLEQKYHFSAELAQQISDFLSPMLCFDPAKRTNAGYMSNSPWLREVADPTFKIETTGATGEDVPGWATEIR
The following text describes a protein:
Function:
Putative cyclin-dependent kinase (CDK) inhibitor necessary and sufficient for PHO pathway-dependent down-regulation of low-affinity phosphate transport.
Miscellaneous:
MISCELLANEOUS: Present with 2180 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasmic granule. Cytoplasm.
Sequence:
MGTYTPLIYNIYNVHIWVFTESQGQIGQMSPRGKMETAVSQGQHKQLKDGHQHKGRKLSEEIASLLRLKECRRLNPASYYTPRRTSQSQSLSGSTFKEYNEYINEKDSSRAQRQNAAAVLSKLAHDFWENDCVIDEDIFEDSSDEEQS
The following text describes a protein:
Function:
Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex. Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner. Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways. Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex.
Subcellular Localization:
Early endosome membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Endosome. Cell projection, ruffle. Cytoplasmic vesicle, phagosome. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
Domain:
Overexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect; The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B.
Sequence:
MPGIDKLPIEETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLTSKLLKEYEKQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKERDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIEDLEVASDPLYVPDPDPTKFPVNRNLTRKAGYLNARNKTGLVSSTWDRQFYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTINNISKQIYLSENPEETAARVNQSALEAVTPSPSFQQRHESLRPAAGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPVCEDQPGQAKAFGQGGRRTNPFGESGGSTKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLVTCDCLKLIDPQTQVTRLTFPLPCVVLYATHQENKRLFGFVLRTSSGRSESNLSSVCYIFESNNEGEKICDSVGLAKQIALHAELDRRASEKQKEIERVKEKQQKELNKQKQIEKDLEEQSRLIAASSRPNQASSEGQFVVLSSSQSEESDLGEGGKKRESEA
The following text describes a protein:
Function:
Participates in the barrier function of the cell envelope.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MWKRLIISLIIIIGLLMVTAIALDRWISWKTAPFIYDELQELPHRQVGVVLGTAKYFRTGGINQFYQYRIQGAINAYNSGKISYLLLSGDNAQHSYNEPMTMRRDLIAAGVAPADIVLDYAGFRTLDSIVRTRKVFDTNDFIIITQRFHCERALFIAMYMGIQAQCFAVPSPKNMLSVRVREIFARLGALSDLYILKREPRFLGPLIPIPAVHVIPDDAQGYPAVTPDQLVELERRLAEKKQPSQ
The following text describes a protein:
Function:
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MARSLLSWLGGCLLMSALGMVPPPENVRMNSVNFKNILRWESPAFPKGNLTFTAQYQSYRKFQDTCTSILLTECDFSSLSKYGDHTLRVRAEFADESSEWINITFCPVDDTTIGPPRMQVEALANSLHVRFFAPRIENEPEPWTMRNIYNSWTYHVRYWKNGSDEKFSISGQYDFEFLRNLESQTTYCVQVRGFLSDRNKAGEWSEPVCEQTTIDETTPSWMVASVLAASVCAALLLLLGCFFLLRCVYRKARHAFPPRNSLPQHLKEFMSHPHHSTLLLFSFPLSDENEVFDKLSVITEVSESCKLNPGAGCGLTT