lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis reaction of one acyl bond in phosphatidylcholine in vitro (actual cleavage point is unknown), resulting in lysophosphatidylcholine.
Sequence:
MWTWKADRPVAVIVIIHGASEYHGRYKWLIEMWRSSGYHVVMGDLPGQGTTTRARGHIRSFQEYIDEVDAWIDKARTFDLPVFLLGHSMGGLVAIEWVKQQRNPRITGIILSSPCLGLQIKVNKALDLASKGLNVIAPSLKVDSGLSIDMATRNEDVIEADQNDSLYVRKVSVRWYRELLKTIESAMVPTEAFLKVPLLVMQAGDDKLVDKTMVIKWFNGVASHNKAYREWEGLYHEIFNEPEREDVFKAARAFTDQYI
The following text describes a protein:
Function:
Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans; Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.
Subcellular Localization:
Secreted.
Sequence:
MKASTIICALLPLAVAAPNAKRASGFVWFGSNESGAEFGETKLPGVLGTDYIWPDASTIKTLHDAGMNIFRVAFRMERLIPNQMTGTPDATYLNDLKATVNAITSLGAYAVIDPHNYGRYYGNIISSTDDFAAFWKTLAAQFASNDHVIFDTNNEYHDMDQTLVLNLNQAAINAIRAAGATSQYIFVEGNSWSGAWTWTTVNDNLKALTDPQDKIVYEMHQYLDSDGSGTSATCVSSTIGQERVQAATQWLKTNGKKGIIGEFAGGANSVCQSAVTGMLDYLSANSDVWMGAAWWAAGPWWADYIFNMEPPSGTAYQNYLSLLKPYFVGGSGGNPPTTTTTTTQPTTTTTTTTAGNPGGTGLAQHWGQCGGIGWTGPTACASPYTCQKLNDYYSQCL
The following text describes a protein:
Function:
Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Midbody.
Sequence:
MATGDLKGCLRKLEASLRSLKYPRDVDYQRLAVGDPSACLPIVSFAFTSFSPSLTEYLVDFGVELTGMNDLRFIENVYKVLRDVFSYKPLLTKQQFLQFGFAERKVSILCDVIGLVLSKHKELTKNSKHLSKPKKRPVLKSCVKNEIPSDDSNSQELTALMMPLKQPLVERHLGGSSAAAQIRHSSAEHPQQEEESEKELDSERLEDSSQPAESTECVLESRLRVLEEGLLETVGRLEQRLALMELKIHALEKSLAGKIIIESNQWENLESRVLLLETRLALTSAQGLTSGDGILSTQNNEFKEDTVSANGSSAVIQTSLDDNDNGNIASPLPTASQSFKERLDRIVYMMKDTSDILQNVEPTM
The following text describes a protein:
Function:
Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break at the junction of the two exons a4-a5 of the COX1 gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Recognizes with limited specificity and cleaves the sequence 5'-TTTGGTCACCCTGAAGTA-3'. The protein may acquire mRNA maturase activity, like the closely related bI4, through a single amino acid substitution Glu-362 to Lys or when present together with a mutant form of the imported mitochondrial leucyl-tRNA synthetase NAM2.
Miscellaneous:
MISCELLANEOUS: Residues 299 to 556 are sufficient for endonuclease and intron homing activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MVQRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMIFFLVMPALIGGFGNYLLPLMIGATDTAFPRINNIAFWVLPMGLVCLVTSTLVESGAGTGWTVYPPLSSIQAHSGPSVDLAIFALHLTSISSLLGAINFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLLLSLPVLSAGITMLLLDRNFNTSFFEVSGGGDPILYEHLFWFFGQTVATIIMLMMYNDMHFSKCWKLLKKWITNIMSTLFKALFVKMFMSYNNQQDKMMNNTMLKKDNIKRSSETTRKMLNNSMNKKFNQWLAGLIDGDGYFGIVSKKYVSLEITVALEDEMALKEIQNKFGGSIKLRSGVKAIRYRLTNKTGMIKLINAVNGNIRNTKRLVQFNKVCILLGIDFIYPIKLTKDNSWFVGFFDADGTINYSFKNNHPQLTISVTNKYLQDVQEYKNILGGNIYFDKSQNGYYKWSIQSKDMVLNFINDYIKMNPSRTTKMNKLYLSKEFYNLKELKAYNKSSDSMQYKAWLNFENKWKNK
The following text describes a protein:
Function:
Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Replication factor C (RFC) complex has an essential but redundant activity in sister chromatid cohesion establishment (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPFISSAELSSRATPPDLQKRKYGEQSQPSEPKRQKIMGGFLDDDDDDDHDGLEAFNEAQYQSEFEIQEQRVDLPQISQSGSRAEPKRPKIMGGFLDNDDDDDDGLEAFNDAHLESQIDTQEQPVKLTEVSRSQSTLESVVINSVTERSTIVPAYAPPNISPTSVKIKTCNGKALNVPLKKPSARVSYERLIASRSTTAPGRAQKSYYGIDIHSLLNESAKEVKAAEAPKPAPVADVRPSIEAPIGDKRSKKLSTAMWTEKYRARKYTELIGDERTNRSILRWLRGWDPIVYPSLARAKQNKKYNNDEEERPHRKVLLLCGPPGLGKTTLAHVCARQAGYEVLEINASDERSRDVVKGRIRDALGTENVKGMNVELGEQKVRKVGRPVCVVVDEVDGVVSGSGGSGEGGFMKALTDLVLLDQRNSARTSERASDGRKRKGDNFRFLRPLILVCNDVYHASLRPLRQSSVAEIIHVRQAPLENVVSRMKSIFTLEGIPSDSDGVRRLCEASWGLAKRKQRGVRSTGAAEGDIRSVLVAAEWVAHKLRNESSAPLRLTRNWLEQRVLADAGGGSFFKGMNRGGVRDIVDRVFTEGAGFPDVPLGDESLQDPYDRSEAVSVDVANIKKRHAIRRLCEMVDASGDHDRCTSECFSSYPLQPYQDDTFLTKPNAAYDWLHFHDTISSRIYSAHDWELGAYLSQATSAFHLLFATAQGKAQQQYREIDEEEEEAHPFSGPRADYAAFEATKQNQAILSTFQSSFSAPLLRLFRSSNNVATELIPNVIRMLSPDIKPVVVRGSEQKSVASVRKESERALVQSAVRVMTGLGVTFEKVRIENEGGGHGGWAYRMEPPLDALVSFSKVPGFSSATNPVRYAVRQVLDQEYRKESIRKNSENLSSTGSKKSTTKSDDIETPANPAEAAKLKYGTAVKRDFFGRIIQDRVPSPQEDMEQALSRKAKSAQQELSSAGRKVWVTYHDGFSNAVRKPISMAELLSGL
The following text describes a protein:
Function:
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLSWLWPQKSVKGDVVVITGGAMGLGRLVALRFAALDATVLIWDLHVALGQELVQEIEAAGGRARFYEVDVTDRAKVYVTGQEVLQEFNAVDILVNNAGIVGGRPVLESSDAMIERTMAVNVTSHFWTIKAFLPMMSQRNKGHIVAVASAAGIFGSPGMVDYGASKSAAIGLMLSLRQELHAMGLFGVHTTIVCPGFIKTGMFEGVRPPPFTSWLTPEFVADQIVKAVRRNQWRVLVPSILSVMEFVATIMPMWFVDWFIRVTKTSQAMKSFKQTRTHALKQDVSSLKVVFTLRPTRLMAQAESSSEALPALHVEPELPPKVARLTGRALFEWNESLTPVSAVQAHLLDLVSDYGVWKTPGKSAPTSPTTATQTGAASNKEKVRLYCIPSIMDIVNIDPMNETFTIKFTLYLLWPVDLHAIGMGEVAQRAMDSGHFINMTAVEIDQFTERTPMPGVTFFNAVETYDSKPADIRVYGGGVLSGFTWVMWNRSIHVQLRERWELQLFPFDVQDLSINLRLNDARSWDYFDLTVCSVQFHREALTLTEFYPLVPQIVREPPAHKATKVRMRVQRIANYYLQNIVLIMSLLSLLGPLAFVLEVDALGDRLSTILTLLLTAVAFKYVISSALPKVPYNTLMDYFILASTVSLVLTAFLCAVPKLLLPHFSASTADTVNKVLGFLSLTIAVGIPIAWTSAAQWMVRRQETFEYIALEPKKNWYHFHFSPTPFMTIAQKEPTATKSGVVYVQKSPPAELFFMASNARWLFGDGGHEVVQVQVPPGSLGILLDGDDLDRPMLEGFAQVSPTDATQRGAVESSGRVPVGSLLVAVNEYNFMEEDLGFHEVGDVLRDTSHLPRTLTFHVPVLESSNLPLSQQFVPRRGPPPREEEDEEGEEDDDGEEEEEDDDEEEEGENGSSSSAGDSFQEIHMTETVAEVEDVAAASAVHVAEDQTSNSSTSWTLTGSNLDGSLNTPLVSSASSASPEKLRSEEPQQVVIEIQTESSLKQPKPQLPKPMEPPPSLPADLSFGSMALAQARHFDSDDSSDDSSGDESQEDGQTSTRGVSWKPVEAKAYSSSAQSASKESLMSPEQPQELSPQKPHQPSPVPLSMASNVSSGTIAASLMAQTNQFDRDDSVEEEDDAEYVTAVAPPGPLGLNLDGGVLNRAVVMGFAKLRDGSKGALERNGGILPGSVVVRINGEDFSRATLNDVRAKLGELGQQPRTLVFRLPPKAQQEEQQNANSTRPTGMRRAPTLPPFEEDHDKRRKLELALVMRYDKSVLARRECWFCIDAKWMARWVGFAARGGPAPGPITNETLLHHNWRKMLASDTPGRPDTARDGLVLMKDYRVVAPMVWCLFAELHGLGEAPLLARFLMDVHAEALSEGEVNTILEVPRPKATVLANNLRDMCLVRPSKLR
The following text describes a protein:
Function:
Transcriptional regulator that plays a role in retinal development and maintenance.
Subcellular Localization:
Nucleus.
Sequence:
MPRPSQLIGHMVQGGSHVAVTSPEAPASPYAATGTCSSRGSSDRKYRGTDRKYRCKGEAVVMPRRKQSHPQPVKWGSEDPLDPNPSSLVLERDLLLGHELEFSDSSDRLLSFCKDSEDSVVCKMEIPCYSLSEDEYSGYRPLSADSDPDDVGMGDPLGDTGRCLDLPLGHRCLPCLTSSSSAGGSPPPLSAPPTHPSGQKERILFPCQLCPFSTHYSSHLKRHMKTHNGEKPFRCPHCLYASAQLVNLKRHLRTHTGEKPFRCEHCGFSCSSPGNLKRHQRVHTQEKPYSCNLCPYRCNQSRNLKRHLLGHRRRGQERQRRGAAPQEEEEDGAEAEDEEEKKIKRRQTEDAPTPALSIPFISGDLSVPTCARLSRAASPPAPPAAPGDSLPELLFPFTCQTCGLVLDEGCHQDGEEEEEEEEGAAEGQSCSRCSTCALGGPGSPGKGFSCVLCSFVTHYPNHLSRHMKTHSGEKPYKCQLCPYASAHYDNLKRHQRVHTGEKPYKCQLCDYACGNLANLKRHGRIHSGDKPFRCGLCSYSCNQSMNLKRHMLRHTGEKPFRCAQCHYTTGHWDNYKRHQKTHGHSAEGWTHPRRSSKVQRYSV
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.
Subcellular Localization:
Nucleus.
Sequence:
MVKEAAAVAALGGAQRARKRFIGVRQRPSGRWVAEIKDTIQKIRVWLGTFDSAEEAARAYDEAACLLRGANTRTNFWPCSPSASPSPALPSKVTNLLLQRLKARKTSLALTSDGLSCQEQKQPKEELMPEVTGFSEIQFSDYLTDPEDYTAEQNFINDAITSHYVTNSESSFNFKEDSGCRAGKEKHCDYSMSDVTQSYSDDGNLGRDGVEDADLRVLDLQFLDKFRPSCYYSPFEIAEEIVEPMEPENDGEEPPILTAAMKRMTFERKYSASLYAFNGVRECLKLQLGSRTAMARAHSNELAKLQNACDKKKDEDKPVGDGFLKVMAEEENPETPTDTIASSSSSSSSNEGESSLWSSLDLPTICSVN
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MLSLAEHADQLSSAIQLRGNLAGESVLVLRALQDKLAELNAKLAPIHERATALTWAEDNITKAKLATDELLRHIDVTRKVESVLRLGPGRSEEQLEVFLGAVGRLEEALDHLEANLVEAVTQPYEHAASVYERAMSDCEADFAAVLAAHGTARLPSAAWLADKAAPENLRASIANPEMELLPAAAVGRVSRLAEVMLRARHVACLDTYAQARSRALDMLLALVGLDPSTLGLAGPGAGGGGGRGGAGSGASMGGGGLALQLQSADQLQRLVVGWSTQLRVLLVGASAELALAQDVWQSPYDEVTFSETISRSLRLVLQVGKAVCEGRGAGRSPDRLFALLQMHQSLMELLPYLDDLLSARERCTGLLNEAHLLGVMIGRAARQLFADFEEAVGGRAGGGAGLSAADAAASKLTMLDGTVHPICATTLSFLKRLFTYPNALSLLFAPSGAGGSVSGGGAAEAAAAAAAAASSSIMHILMRLLEALEAKARAYKSPALGSLFLMNNVHYMVWTVEQAAAADKQKASAAAAAKTSAAAAAEAEADAEAASLEAEGATVRARRRARRAAEAAAEAAEAEAAAAAAAHPDAAVPGGLAVLGRAWVERHKDIVEHYGAAYQEASWKPLTELLEAVVVTETDKEPSDPGRFKNWVKSKFAKINTLMEGVLKQQSSWTIPDAKLKNAVRKVIKQDVLPLYGEFWERYTEVDFTTHPDKYLRYPPEQLEHVIDHTLFEGRAAPPRAGGGGGQAGGGGGLLSFSSPGSVKSAATGRAGKDAGGGGGGGSAAFPPGVPASTQSRVSSKVGSVRR
The following text describes a protein:
Function:
Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status.
Subcellular Localization:
Cytoplasm.
Sequence:
MMLPLRTLLKWSVNRSCSRAFAVSPQSYTSAKKGLVLGVYEKEKEEESLILTTAGENFDNAVSGKLRDQLSRSGPALKKGKSRIFYGLHEDFSSIVVVGLGKKSIGVNQQEIWNEAKENIRAAVSVGCRQMQDMEIAQVEVDPCGDAQAAAEGAVLGLFEYDELKKKKKKAVTTHLHGSSEHKAWEKGVLYAEGQNLARHLMEAPANYITPTKFAEIFEQKLASMDSSVKVFTRSKPWIEEQQMGAFLSVAKGSEEPPIFLEIHYSGSSDASQPPLVFVGKGVTFDSGGISLKPSSGMDAMRADMGGAATICSAIMIAAKLKLPINIIGLAPLCENMPSGGANKPGDVVKAKNGKTIQVDNTDAEGRLILADALCYAHSFNPRAIVNAATLTGAMDVALGSAAAGVFTNSSWLWTHLQEASVITGDRVWRMPLFEHYSKQVTESALADLNNIGKYRSGGACTAAAFLKEFVTAPHWAHLDIAGVMSNKDEVPYLRKGMSGRPTRTLIEFATRLSEDNQTV
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSGVGQSLGGSSTKEVNAASLCRLGQETVQDLVTETQDMFSNLKGVQLPNGRSNTQQSHQDKITKLQDITKHIEVHFKKLRLLYDKCIQISSGVHTASGTHTPSEDLIMWKDVISSKDLIALGSREKAQYLNDERLHLMEQLQAKNRQLRQVMEQMRHLMWDINTMLATRHSTPDWK
The following text describes a protein:
Function:
Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSLITAGRVCARILGAKNSPCVLIAARQASSSTNLKDVLSDLIPKEQTRIKNFKQQYGKTAIGQITVDMVYGGMRGMKGLVYETSVLDPDEGIRFRGYSIPECQKLLPKAPGGEEPLPEGLFWLLVTGEVPNQEQVNWISKEWAKRAALPSHVATMLDNFPTNLHPMSQLSAAITALNSESHFARAYAEGVNKSKYWELVYEDSMDLIAKLPCVAAKIYRNLYREGSSIGAIDSNLDWSHNFTNMLGYTEQQFTELMRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFSAAMNGLAGPLHGLANQEVLVWLTSLQKDLGGEVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPDDPMFKLVAQLYKIVPNILLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTDGLMQLVGSKSG
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Sequence:
MSSTTNEANNKTATAAQQSWSVEDVVKAEFPVVPKENSESPVPFFHMLERLKTTKREGWRRFGIKRGESISDHMYRMSLITMFAPESLASKINIPHCTKMALVHDMAEALVGDITPVDGVPKSEKSRREATTMDYFTKNLLGRVNGGLAGQQIMDIWQEYEDSITLESKFVHDVDKIELILQMVEYERSEEEGLDLGEFSWVATKIVLPEVQAWADEILKEREEFWAGKNHLVYSQVKKPDEKKLAQTDEYYGGKENEVTKG
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MLSSPSIPQLIATAYAQALPPSRLLKTLQEVHLHNLSPSVQYDLIRAFLDHLLPVPPSIMLAYLAHALSTSVITTQDFTIGLLFYMSGHEIPPIESLVSIVNVLMENPTCFEDGTILPSMLSDPALVQSDTNGELSKYRDNNQTSTLSLLLPLLRVSATPFPPPTLTAFIARLLNCLSPFPVPPLDVGLEAGQLLPSLTDEISIPLRNCLGGLMADATTNDPQQVEQVVFQQDSQLAQGDSPSQVEMPTNSSLPLKATVAFLLEQAHRASQWDPSELALEMEHYQTPAPSYVRMLKAGQHICSNPEEFIVVLFEVSIERLISEDGRSLIAKAEGIRDWGWVTESLPNLLRWWRSQREEDGFVGWQLPSVVAEPLTKAVQVFLPAMQSYSEKVLETYEVMVQSAEIEEESSGFTPPESWQLVSLQEYLIGKLIEMELITRTEACKMIPTISVPQTVQGQSLLERMESESRAHVKPLVFIITYAFGAAKSFAYEIVNIIKSSPQVPPPENLFLHVSYQPSIFSALVTFISPLSLYTLMSDRLLEAYSELDEFARSDDPQGYLTRFGEGVILLESFAREFNLDLPELLANGRRATGYGLLDAEQKDCLNGWVKAIFGSDGIEDQILLATPPQTLCCLVPTLIQQAIAAVACNQIDLDTLHSGLSYFSQPLLSWCLGGVIEWLCDEILRQGALSALHLVVLQALAMGHACPEQLLKVNDRALRKLFNPLSGLDEVIGTSNFDMFAFKAKLESLGITTSHHYGPLNQPSVKSSIQSISSLPFATAFWANPLLDSLWASAGTSNWMTVVLKNIFSQLDTFPVSPVGSACQRSGVYANFVPFLLMVDIKGNEPLLSGLAAWLRNSTEDLIHYTRGSRVLAGIFTQCILLADLIWGRVMAKRVIKELVVELHSVTTLGVRSGGQSEETTQLHSRKMKHRDGRRLTSEQRSMCEDIVKMLTYDDGLRARWGNHWVDLAV
The following text describes a protein:
Function:
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in regulating activin-mediated signaling in neuronal cells (By similarity). Enhances the ability of PTEN to suppress AKT1 activation (By similarity). Plays a role in receptor-mediated clathrin-dependent endocytosis which is required for ciliogenesis (By similarity).
Subcellular Localization:
Cytoplasm. Late endosome. Synapse, synaptosome. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Note=Membrane-associated in synaptosomes. Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation.
Sequence:
MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVTNMEKASIEPPEEEEEERPVVNGNGVVITPESSEHEDKSAGASGETPSQPYPAPVYSQPEELKDQMDDTKSTKPEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPAEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPADGQLDGTYPPPVHDDNVSVASSGATQAELMTLTIVKGAKGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPVGSETSLIIHRGGFFSPWKTPKPMVDRWENQGSPQTSLSAPAVPQSLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYANSNHAAPSNNASPPEGFASHSLQTSDVIIHRKENEGFGFVIISSLNRPESGATITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNNPTSAPSSEKQSPMAQQHSPLAQQHSPLAQPSPATPNSPVAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYSQPSPLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTTNPTPGALPLPPPQACRK
The following text describes a protein:
Function:
Upon expression in E.coli functions very weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity.
Sequence:
MAESGESPRLSDELGPVDYLMHRGEANPRTRSGIMALELLDGTPDWDRFRTRFENASRRVLRLRQKVVVPTLPTAAPRWVVDPDFNLDFHVRRVRVSGPATLREVLDLAEVILQSPLDISRPLWTATLVEGMADGRAAMLLHVSHAVTDGVGGVEMFAQIYDLERDPPPRSTPPQPIPEDLSPNDLMRRGINHLPIAVVGGVLDALSGAVSMAGRAVLEPVSTVSGILGYARSGIRVLNRAAEPSPLLRRRSLTTRTEAIDIRLADLHKAAKAGGGSINDAYLAGLCGALRRYHEALGVPISTLPMAVPVNLRAEGDAAGGNQFTGVNLAAPVGTIDPVARMKKIRAQMTQRRDEPAMNIIGSIAPVLSVLPTAVLEGITGSVIGSDVQASNVPVYPGDTYLAGAKILRQYGIGPLPGVAMMVVLISRGGWCTVTVRYDRASVRNDELFAQCLQAGFDEILALAGGPAPRVLPASFDTQGAGSVPRSVSGS
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K9me3. H3K9me3 marks chromatin regions for DNA methylation. Dim-5 recognizes Arg-8 to Gly-12 of the H3 tail with Thr-11 and Gly-12 being the most important specificity determinants, the recognition of whcih is important to distinguish H3K9 from H3K27 and H4K20.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Sequence:
MEKAFRPHFFNHGKPDANPKEKKNCHWCQIRSFATHAQLPISIVNREDDAFLNPNFRFIDHSIIGKNVPVADQSFRVGCSCASDEECMYSTCQCLDEMAPDSDEEADPYTRKKRFAYYSQGAKKGLLRDRVLQSQEPIYECHQGCACSKDCPNRVVERGRTVPLQIFRTKDRGWGVKCPVNIKRGQFVDRYLGEIITSEEADRRRAESTIARRKDVYLFALDKFSDPDSLDPLLAGQPLEVDGEYMSGPTRFINHSCDPNMAIFARVGDHADKHIHDLALFAIKDIPKGTELTFDYVNGLTGLESDAHDPSKISEMTKCLCGTAKCRGYLW
The following text describes a protein:
Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAATAPSAGGSASEAAGSAEAPLQYSLLLQHLVGDKRQPRLLEPGSLGGIPSPAKSEEQKMIERAMESCAFKAALACVGGFVLGGAFGVFTAGIDTNVGFDPKDPYRTPTAREVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAGLKAGVIGCGGFAAFSAAIDYYLR
The following text describes a protein:
Function:
Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression. Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity); [Isoform 2]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Also inhibits hypoxia-inducible ARNT-mediated gene expression; [Isoform 3]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation; [Isoform 4]: Attenuates the ability of transcription factor HIF1A and EPAS1/HIF2A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. May act as a tumor suppressor and inhibits malignant cell transformation; [Isoform 5]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation.
Miscellaneous:
MISCELLANEOUS: [Isoform 5]: Incomplete sequence; MISCELLANEOUS: [Isoform 6]: Incomplete sequence.
Subcellular Localization:
Nucleus. Cytoplasm. Nucleus speckle. Mitochondrion. Note=In the nuclei of all periportal and perivenous hepatocytes. In the distal perivenous zone, detected in the cytoplasm of the hepatocytes. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes with BAD in the cytoplasm. Colocalizes with EPAS1 and HIF1A in the nucleus and speckles (By similarity). Localized in the cytoplasm and nuclei under normoxia, but increased in the nucleus under hypoxic conditions. Colocalized with HIF1A in kidney tumors.
Sequence:
MALGLQRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQPRAGSAQAD
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MQQIDNLEYVDQVNSWLDLSNLLIKLAPNQQKQFTKELRDKLKSGNYLKPAPIQKMVLPFLLQEKTEERFVYIKSPTGTGKTLAFILPIIFFFDQDYIQQYYQAQQDGPVQYYPYAIILVATHALLAQIQKDFIGATPDILLKQGFKVQHFDKGQDESIIMGHVICGVPQTILKLIQKKTINLKNVRFIVVDEADNTILNDKSQKVIQIISKFLESNNLRWKIISCGATMEVNELKSLFIKSLGEKKQGDEEFFKFKYFDFQITLDNIYHYYDGSTDREEDMLKKMVSVIKDTFTTFAEAQIMIFFNAKSKCHETKQLLMNDPQLKFLVEGNCLCEIIQDNIQDYGGAEEMRKAQQKIVDDFKNGVYKIMFCSDLMGRGMNFRKVRLVINYGAPRVKPDGEFDLRRYNQRVGRTGRMEDLGVALTLLKLSSKSLNSDIPEVKFTDFLQSEIPGLILKKYETTDFFKQLKEVYTKTQQKQK
The following text describes a protein:
Function:
Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.
Subcellular Localization:
Cell membrane, sarcolemma, T-tubule. Endoplasmic reticulum membrane; Single-pass type III membrane protein. Preautophagosomal structure membrane; Single-pass type III membrane protein.
Sequence:
MALGGGGGGGGGGEAAGGEGAPASDGDSGSSLAGFWPAWVVALVAALLAWLWYGRGAQKEKKDKGEKEAQATGGGAPLRGKAPQEEPNQRNYETKQTDVSSLQDLVENQFSSSDHCALNVPNNSPETEPLVKESTIPLMNYKEYLRATTPSEPALNQESEKHGGGPSSEKCEEKCKEKLQHSVDEEWEIVPEHSGCDSTTRKSSVDDASSKDTDPSKRVAAVSPMPQTVHVTFRVHYVTHSETQLLAITGDHECLGQWQHYVPLRCDKDWFWSDSVVVPVDTRIEWKFIVVENGKVRRWEECDNRTLTTEHVDRVAHLWWGYH
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MARGKRGTRGRGRGTGKAKEAAENEIAEENMAEAGDGELDEFDVEDNGEEDGEKTEMDDSVADEEQGEVEAENGEADKTEAEKPIEDVQQSEETPMETQETTKDSEEEEKKPAEKPVEEEKEASTDKTEEAAEDTEEKTPTSEEPKKEGGSKRKRKKERTRPYELEKYWKAVKTNPADFTGWTYLLQYVEQEDHMPFYREAFDAFFKCYPYCYGYWKKYADSERKKGTIERCWEVFERGLKGIPLSADLWLHYISVTGQQIPRSDDTRTEKLRALYERALDVAGKDFRSDKLWDQYINFEKKEQKDWKRVMQLYDRILKIPTQLYRHHFDKLKEFVQAHLPKEYLDFDEFLNFREQVVAEAGPEEVDDDAMIPGEDAPPGEEAPPGEEAPPGVGPPSTRVIEGENKLIQEKVIESRRVVFRKTEQEVSKRWAYEEAIRRPYFHAKPLEKGQLKTWREYLEFEETTGSHDRTVLLYERCLIACALYEEFWIKYARFMEKTSQEAASEVFKRACGTHLPSKPAINIQWAAFEERYGNIERAREILEQLQVKQQDSVMIRLERINFERRACNHEEVIRLYEGCIDDAKTATGQSFFAGKLGRFYQKVLGDTDKAIEVLEKVLIQKQVSPVLKEQIYTLIMDVEYQRSPLNEEKMTALFDTVISSNLPQDVKIQFAQRRIQFLQDFGSNPAATHDAVDEHQKLVKNISSSKKRSADSSGDAPPTSNTAASDTKAPEKKKAKTVGGGANNQTDKNSSGSGYNNYNYNQQATGAQAAAAAPAPAANTGLSGADYPPVSWESWGAWGAAQQ