lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As part of the translocon PTEX complex, plays a role in the export of parasite proteins into the host erythrocyte (By similarity). The translocon PTEX complex is a multi-protein machinery resident in the parasite parasitophorous vacuolar membrane, responsible for protein secretion into host cells. May contribute to the unfolding of proteins containing the PEXEL localization motif before their passage through the translocon or regulate the PTEX complex function.
Subcellular Localization:
Parasitophorous vacuole membrane; Peripheral membrane protein. Note=Appears to localize to other uncharacterized organelles.
Sequence:
MKKYIFFFLFSFINFFFVYDVTCTKEVTSTNDDPLTPLNRFDKYYLRMFKKVPRLQQNGSNIINGVNMKNTVIVLYFFAKWCQACTMQSTEMDKLQKYYGKRIYLLKVDLDKNESLARKFSVKSLPTIILLKNKTMLARKDHFVSSNDLIALIKKHL
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MAKPVHLTTRTAGFSFTSISRSRIGAKPIKCPAQVTFSLDPYTPTQSFPDCNTMITVKGPKGQLSMPIKPYVSITLPSITSNTTKQTDFADDDNLYDNLKSKSANALLTVAVDTYTDKRQRAMWGTTRNLIQNMVIGVTDGYMIPVRLVGVGYRAQLDAVTAGKSSPSQNRAPSAPEDGNQLVVRLGYPHPVIFHVNDTVQVSVPAPQRIILQGIDLHAVTAFAANIRKWRKPEPYNQKGVFVGDETIKKKDGKKR
The following text describes a protein:
Function:
Involved in the depolymerization of actin filaments. Enhances the filament disassembly activity of cofilin and restricts cofilin localization to cortical actin patches.
Miscellaneous:
MISCELLANEOUS: Present with 11100 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, actin patch.
Sequence:
MSSISLKEIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADACIKRWNVVLE
The following text describes a protein:
Function:
Metalloprotease.
Subcellular Localization:
Secreted.
Sequence:
MCASCLHNANAASFLMETFSRHRLNFICIGKMNIFYNVTSLDNKYSFHNPSAPVPHSSHALSSRQAHFTSFRAPVAPPSRPRRSQLPSSAKLLYCFDSSFSTEKRELMLFSMNFISSQTCVTFEENCSIPNRVQLVNGKGCSSYIGMNNIVQHLTFNDTCIDFGTAVHELMHALGVIHTHSRLDRDNFLNINLTNVSKEMMHNYAIFNQSTNVVPYEYGSTMHYYANISTMFPKKSEYSATLGIGRVTFYDMVILNTAYNCKCPNELLCGNGGYTNPSKCSECICPLGYGGVLCDRPSLIGKDTGLPLEVKDKIIEVKVVGIDNFFSYPTCLINGLEIKYMGDPRITNPIYCSADLINGKSFRSKLNPLLMNIHTLFGKNKVTFHYRYVTERLSGYNKTTNGYDNYEYYD
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Nucleus.
Sequence:
MAETTELIQHIELYVDTSRSPTEQAASLNSIISLVKSDFLTIEVLVKEMRMYLTTTDNVIRARGILLLAEVLTGLASKPLDNATIHSLIGFFTDRLADWRALRGALVGCLALLRRKVNAGMVSASDGKLVAQSYIESLQVQSLGQHDRKLCFELLECLLERHPNEIASLGETFFYGICQAMDGEKDPHCLMLTFPIVETLVRIYPDPSGSLASFCGDLFELLGSYFPIHFTHLKDEDAEVKRDDLSKALMSAFSSTPLFEPFVIPLLLEKLSSSLPLAKVDSLKYLNHCTAKYGADRMAKHAGAIWISLKDAISNSLEKPDMSFTSEPLYGLGFQENEIATEALMLLQKVTLQNEALFLSLIIQDEGINIVFNSIASHEHYNNIPLQGKQWLHAVGRILYIISKTSMASCNSVFESFFPRLMNTLEISVTNSAGDCTLNENTFPSKKFNFGALYLCVELIAACRDLIMRSKDLAPKPDTPQETCRYMLQSFADSLVNAFSSSLATNANEVAHGADIYFKVKGLQILATFPGDFLPISKFLFANILTILMSIILVDFNKILLWKLVLKALVHIGSFVDVYHESEKALGYMGAVVDKTVSLVSRDDVKMPFSLKLEAASEIGASGRNHMLKIVQGMEEAIVAKLSDYVHGNLKSAEKTIQLLECYCNKILSWINETGGLEEVLLRFVINIWNCVESCKDFSIQVQEEELLDATMMAMKLAIGSCSEESQNIIIHKAYSVISSSISIPFKESLDATSSIQLEELSVSEQIDNSSHRDDQIDKFSLRDEWILSHFASVIIAVRPKAQIVNVKGILHLFMTTVLKGCVPAAQALGSVINKLGTKSNETANSIDCTLEEAVDMIFRTKLWNLNENGVLRTCGSGNGSKVGLTDLCLGFSSNKLLRVHAVVGLAWIGKGLLLLGHEKVKDVTKILLECLLSEGRIRAMELKQGLLENSYEQHSVMRSAADAFHILMSDSEVCLNRKFHAIARPLYKQRFFSTVMPILQSCIIKSDSSVCRSMLFRASAHLISNAPLIVILSEAKKLMPVLLDGLSLLSEDILDKDKLYSLLLVLSGILTDKNGQVAVIENAHILVNCLTRLIDYPHMMFVRETALQCLIATSELPYARIFPMRTQVLQAICKALDDPKRAVRQEAVRCRRAWASIA
The following text describes a protein:
Function:
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSQFKKTDSKIYAKTATVLSPDTIYWKKLGVPTLVKEFGAIDYIDFCPVEPYLFAVTASVRVQIYNPITKLVVKNITKFQEAAHGGSFRKDGNLLVAGDELGKVRLFDVTTRTILRYFEGHKAPVHRTFFTADGHHVASFSDDRTVGYWDIATENHLHTFTGHEDYIRAGCTSPVSPNIILSGGYDRKIRMYDTRVKECVMTVDHGQPVESLVFLPSGGIFISAGGTSVNVYDALSGGRQLAQLSQHHKTVTCLQLASDGKRLFSGSLDRHVKVYDIATYQVVHTIDSSNAILSLGISKNDDTLVTGMVDGLIAIYRREGDPRDEQPTQRVRKGHHQHIFEPADQQVEEFKFVRYEGHDRALRKYEYKKALDAVMAAKVRGMWPEKTVALIKELIRRKGLHRALDDRSPESLVHFINFLTRHIGDYRFTPVLIDAGNILLDVYEDSLEKFAGTIVGKAFVTLANKLQTEEQLVLEFLNLQGMLDMISVAADTAEPDTVDDAIAPYDASNKAKNQTVISVD
The following text describes a protein:
Function:
Part of an unusual four-component transporter, which is required for protection against the killing factor SdpC (sporulation-delaying protein).
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEENEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLEKEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKTAEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKDLVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQAVQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKAKRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIWMNILVFSDPKGGGGGGGTKVGVKSESGGGMMENIAEAKKVVHVGVILDVNSPVGSVANACISMAISDFYGAHPNFRTRLSPHHRNSDDALAAAFTALELIDKEEVDAIIGPQTSKQARFVIDVGRKAQVPVISYSATSPSLSITQNPFFVRVALDDSTQAKVITAIVQAFEWHEVILIYEDTEYGSDLIPYLAYEFQQVDIRVSSRFSFSPNDSKLRILKKLNKVMAMQTRVIVVHMSSSFGSKLFFLAKDVAMISEGYVWIITDGLSRLLDPMGVKAFGSMQGVLGIRPYIPQSKGLKNFKRKWQSRIHSSSTKLNIFGYWAYDTIWALAKAVEMIPQESSSVNGENHHRNTSQFPVIKVSKRGKMILNGLLKTKFKGLSGDFSLVGGQLQSLTFEIINVIDNEEKVIGYWTLENGLTRKPDKAKMENQCPNMNLNHLYGQETRKTNPEDPYTKEFIITGFSHDVFEEALALLSFPVPRKLIPFPIGPNGGTYDELLSNVKNQTYDAAVGEITILANRSQHVDFTLPYLQSDVSMVVKSKDDERNNMWIFLKPLSWDLWLTTGVAFVCTGEKIINNLSKFVLIIWIFVVLILTQSYTASLASMLTVQRLEPTIIDIDELKMNGDFVGYETGSFVKDLLVKQLDFDESKLRDHGTAEEFDKALSKGSQNGGVGAIFGARHCVNLFLAKYCDKYMIVGPTYNTDGLGFAFPRGSPLVPVISRAILSVIENKSKMDAMEHKYFSHLKACQTTISSSSLGLYSFGGLFIITAVASVSSLIIYFTKFLQSHWTTIHTVHHDSSFWSKISELGKHFYDQSLYPLPATNSTLQSVEALHDVENEGVDTVVIVGNVSSSTL
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).
Miscellaneous:
MISCELLANEOUS: Present in outer membrane vesicle formulations which are used as vaccines in human.
Subcellular Localization:
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Domain:
Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
Sequence:
MMSVTVETLENLERKVVLSLPWSEINAETDKKLKQTQRRAKIDGFRPGKAPLKMIAQMYGASAQNDVINELVQRRFYDVAVAQELKVAGFPRFEGVEEQDDKESFKVAAIFEVFPEVVIGDLSAQEVEKVTASVGDAEVDQTVEILRKQRTRFNHVEREARNGDRVIIDFEGKIDGEPFAGGASKNYAFVLGASQMLPEFEAGVVGMKAGESKDVTVNFPEDYHGKDVAGKTAVFTITLNNVSEATLPEVDADFAKALGIADGDVAKMREEVQKNVSREVERRVNEQTKESVMNALLKAVELKAPVALVNEEAARLANEMKQNFVNQGMADAANLDLPLDMFKEQAERRVSLGLILAKLVDENKLEPTEEQIKAVVANFAESYEDPQEVIDWYYADPSRLQAPTSLAVESNVVDFVLGKAKVNEKALSFDEVMGAQA
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MALLIVILSMFYLGLMGILLNRLHFLSILLCLELLLISLFIGIAIWNNNTGVPQNTTFNLFVLTLVACEASIGLSLMVGLSRTHSSNLVGSLSLLQY
The following text describes a protein:
Function:
Involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MKTKTILTALLSAIALTGCANNNDTKQVSERNDSLEDFNRTMWKFNYNVIDRYVLEPAAKGWNNYVPKPISSGLAGIANNLDEPVSFINRLIEGEPKKAFVHFNRFWINTVFGLGGFIDFASASKELRIDNQRGFGETLGSYGVDAGTYIVLPIYNATTPRQLTGAVVDAAYMYPFWQWVGGPWALVKYGVQAVDARAKNLNNAELLRQAQDPYITFREAYYQNLQFKVNDGKLVESKESLPDDILKEID
The following text describes a protein:
Function:
Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASGGHERANEDYRVSGITGCSKTPQPETQDSLQTSSQSSALCTAPVAAANLGPSLRRNVVSERERRRRISLSCEHLRALLPQFDGRREDMASVLEMSVYFLQLAHSMDPSWEQLSVPQPPQEMWHMWQGDVLQVTLANQIADSKPDSGIAKPSAVSRVQDPPCFGMLDTDQSQATERESELLERPSSCPGHRQSALSFSEPESSSLGPGLPPWIPHSWQPATPEASDIVPGGSHQVASLAGDPESSGMLAEEANLVLASVPDARYTTGAGSDVVDGAPFLMTTNPDWWLGSVEGRGGPALARSSPVDGAEPSFIGDPELCSQELQAGPGELWGLDFGSPGLALKDEADSIFPDFFP
The following text describes a protein:
Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Zona pellucida.
Sequence:
MWLLRCVLLCVSLSLAVSGQHKPEAPDYSSVLHCGPWSFQFAVNLSQEAMSPPVLIVWDNQGLLHKLQNDSDCGTWIRKGPGSSVVLEATYSSCYVTEWDSHYILPVGVEGAGAAEHKVVTERKLLKCPMDLLARDAPDTDWCDSIPARDRLPCTPSPISRGDCEGLGCCYSSEEVNSCYYGNTVTLHCTREGHFSIAVSRNVTSPPLLLDSVRLAVRNDSVCNPVMATQAFVLFQFPFTSCGTTRQITGDRAVYENELVATRDVKNGSRGSVTRDSIFRLHVSCSYSVSSNSLPINVQVFTLPPPFPETQPGPLTLELQIAKDKNYGSYYGVGDYPVVKLLRDPIYVEVSILHRTDPYLGLLLHQCWATPSTDPLSQPQWPILVKGCPYIGDNYQTQLIPVQKALDLPFPSHHQRFSIFTFSFVDPTVEKQALRGPVHLHCSVSVCQPAETSSCVVTCPDLSRRNFDNSSQNTTASVSSKGPMILLQATKDPPEKLRVPVDSKVLWVAGLSGTLILGALLVSYLAVKKQKSCPDQMC
The following text describes a protein:
Function:
Lipid transfer protein required for autophagosomes completion and peroxisome degradation. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Atg2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region. The latter binding is assisted by an atg18-PtdIns3P interaction. Atg2 then extracts phospholipids from the membrane source using its NR and transfers them to atg9 to the IM through its predicted beta-sheet-rich structure for membrane expansion. Atg2 is also involved in the recruitment of lipids to a restricted region close to the vacuole, termed the vacuole-isolation membrane contact site (VICS), which is also essential for autophagosome formation (By similarity). May have a role in sporulation.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Localizes to the IM-ERES contact site.
Domain:
The N-terminal region (NR) associates with the endoplasmic reticulum (ER) and is responsible for the formation of the isolation membrane at the PAS; The amphipathic helix in the C-terminal region binds to membranes and facilitates atg18 binding to PtdIns3P to target the atg2-atg18 complex to the PAS.
Sequence:
MRLPSWLKNSSSWLWTAALSRTVQRRLLAFALRKLIGSILLENVQPEDIDILFSKGVLMLSNLQLNCSFLNAVVSLPMINFTKGTLRRLILRLNVTDIVNLNVELEVNGLSLEIELVPPDESLSSTTYEDAPSQLDILDNVVEYMNKTASQDFEDEVINEGLESEIDGSSHNLLDSILQKCLASTSVLMQDALVYIGTANMSTRLEAKLDFMSFSSVKSNSTSRLLNINGITVSMVRPISKSNAGSSSPPRSEESFVSMDSSSSIVEGFENDLSPSQVTLNESSIISSNREEESFYSVHDSVTQKKTRTSWLIFQCSGEFRLVFSIESSNLLVIESHVPSCVLNINSQVIAFLLYLYGYFLPAPSTPGFSSNKPPLTMLQLDIHISSVQILTHCKLPESQDFSMHNDVDELLHTIPSNGAVFEMKINQIQIFNDNNDIDELTMTFSDLDIFMDSVTLVSFGKSLQSPCSLIFKKLERIVSLFIHIPGGEISLPLGKALLLQESFVEFTNDISNLQNFLSNSDPFKRSIQETFEAPKPFEVEMNQPSFEIIALFDELQLQILNELSTQSLYKLTLRVSHLQFTRKSTGSLSSVLIFVKKIGCQSELFNCENSDWTKVSSSTAFHLSNSLFETHDTTGTSNFAVSIQQEKHYYPVFQPAPTEFSYPEKHFYFAVDNFNVFISKEVVRLFKTLYETIASSLVTPVTPNKLVTSDYKNVLKIRTRTFSLSLLNDDGSSFALKCIRIKHYMCWAGAQLISLSLRLYNVSAEYLSESLEILPVVSFIRNLRNDEKYLLNADFSYALKRSSGSNDNTIFVKITDLGYEHYPTCPWISDLLKTYFPQDPEVPFLAFPDFPFNIKLDLRESIIGLNPRTLEAKLLLYLKSLDVEIDALVASNPLNIRIMAAETVVYIIDKLNQSVLEGKTSVLKREILNSSLHFPGLSIKDTIEFVVKSLGYVEISQLKNLTLSLVVNAEEGVFSTLITVDNLDAQVQSCADSTELLIKVLSDLGSTEDEEISDCYLALPIEDYAKSLTEVDYNFFENRGIDYKSNPTEQSTVLVSSDNDISSQEIKIVDDYYISSNEHSTHASDLASVSSEEFVIDDGSSSIIDISDELQDESSSRDSLKKGIELIEDYYLSQSTSKLESSVEGKNYLLKVKFKDINVNWDLHDGYDWEATRATISSAIEKLCDSSSQNDKISPEAKTLLFQSIVIKSFSKVGRLNINHVSEPIDSDEFADYLSKSISYHLRLGKSKSKKIGIEIKDLQGSFTVYADSNEPNAVLNDLDIGLKDLIIYDHLSTSTWNKFFGRDSRSPSSKNRNQHMNAQIVTVRPLPELNNRELRLEFSVLPCKMYIDQDTLDFLIRFLTFQTPSSSETLNTEPDLPFFQSICINATHVTIDFKFKSADKVGLRSGKLPDLGSLIVMQGSEVFLRQLQIYGLSGAEEFLNALLNVWLQDIRNNQLSKVLNGVVPIRTMFTVGRGIKDIFVSPVRGLQGNHSVGSFRHGIIKFTEKYVNDFLSLNAQGATGTHSLLRQAESYLERGSNASASASRARSYYAEQPETIEQGLRQGYSGLKQGLLGAKSTLMGLPRETRSHKSLGGVAQTVGRKVPLIVLQPMIGATEAVSKTLLGLSNSLQPQRRQDMREKYKRPG
The following text describes a protein:
Function:
Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation.
Sequence:
MASDTPESLMALCTDFCLRNLDGTLGYLLDKETLRLHPDIFLPSEICDQLVNEYVELVSAACTFEPHETFFSLFSDPRSTRLTRIHLREDLVQDQDLEAIRKQDLVELYLTNCEKLSAKSLQTLRSFRHSLVSLSLSGCANIFYEEDNPGGCEDECLVNPTCQVLVKDFTFEGFSRLRFLNLGRMIDGIPVESLLRPLNSLAALDLSGIQTSDATFLTQWKDSLMSLVLYNMDLSDDHIRVIVQLHKLRSKILTCGPHLISSHLDISRDRLSSYYKFKLTRKVLSLLVQKLGNLMSLDISGHMILENCSISKTDEEAGQTSTEPSKSSIMPFRALKRPLQFLGLFETSLCRLTHIPAYKVSGDKNEEQVLNAIEAYTEHRPEITSRAINLLFDIARIERCNQLLRALKLVITALKCHKYDKNIQVTGSAALFYLTNSEYRSEQSVKLRRQVIQVVLNGMESYQEVTVQRNCCLTLCNFSIPEELEFQYRRVNELLLGILSPTRQDESIQRIAVHLCNALVCQVDNDHKEAVGKMGFVVTMLKLIQKKLLDKTCDQVMEFSWSALWNITDETPDNCEMFLNFNGMKLFLDCLKEFPEKQELHRNMLGLLGNVAEVKELRPQLMTSQFISVFSNLLESKADGIEVSYNACGVLSHIMFDGPEAWGVCEPQRAEVEDRMWAAIQSWDINSRRNINYRSFEPILRLLPQGISPVSQHWATWALYNLVSVYPDKYCPLLIKEGGMPLLRDLIKMATARQETKEMARKVIEHCSNFREENMDTSR
The following text describes a protein:
Function:
Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
Sequence:
MAAHHPRESQWPKKELPEARKIMKQIGAQIPRIVESIQVDWSALGRVVAEEVKSSEDMPPVAASTKDGYAVIAHDGIGLKKMVGVSLAGNIYQGAVEIGKCVRISTGGIIPEGADAVIMREYTELVRQDQQSEETEIICKQAVQVGENIRLPGSDVRSSDVIVPFEAQIGSAEFGILNAFGIRTIKVYKKPVVTVISTGSELVSPMVENVPLGMVRDSNAPQLVALFKEHGFNVIDGGRVVDDKEGLDKKLTECLEHSDVIVTTGGVSMGEQDYMKNALLHLGFKIEFGRVSMKPGLPCTVATRESASERKLKVVLALPGNPASAWVCSHLFAVPLIRDMSGYRRINHTKINVRIAQDIKLGDRPEFVRAFIEQVGDEDDGHPIAHVTKNQISSNIGNLVGAQVLLELNAASADKTVVPKNGLVKALILSSNGNF
The following text describes a protein:
Function:
Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Together with msh-5 and zhp-3 plays a role in the activation of DNA damage-dependent apoptosis at the DNA damage checkpoint in pachytene cells. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair.
Subcellular Localization:
Nucleus.
Sequence:
MYSNKSFQRRQRQQVAESRSEEKFSRSLVRLNAQSLLDSSGNNTTTKNVNSDVVIVVMEGRGSCEGHIGIALHDTCFPEIHLCEFVDSREYTTLKTMINVHEAFDIVIQNGNEERGSTKLLGEALMTAFPEASLQSISSKYFNSERGERQLQSLMNAEVSTVSEGCLRRTLALGALAVLLKYIHETRCVFFRVKSLRIKEMGVNDTCMIDFVSWESLEIVDADDASKARKFQMKQKRTLMSVLNHTVTTNGYRLLRSSVLQPSTDVYLIQSRQEAIEELIGKPQLKDKLRRTLSRAHELDRVIAMCIQTSTSWTVRESEAKINQIIKLMHTLKVIQGIRTLLHSAKMKSNILIEKTEFLKDPRFDQIMNILVEKVDDSLLDGKKNSLHLQNTKCYAIRHFVAVQLDLARQTYEEIIRNVEETGAREIAEYFHGNSSVRLSFSQSRGFHYTFVTRQAESVTIPRYFLDVFRNRTTVTFNSRKVIAYNDRLEQVVAEMFLASDVIVCDMIEEMQPMIPVLYYAMDALSSIDFLCGLATYSDLRDTCKPTFGPSFSISQGRHPILDWDDSEKTITNDTCLTRDRRFGIITGPNMAGKSTYLKQTAQLAIMAQIGCFIPANYASLPIFNRIFSRMGHNDELIRNKSAFASEMSDAAAIVQYADKNSLVVLDELARSTSTEEGIAITYAICEKVLKLQSYTFLATHFLDIAALANYSNAIDNYHFLPQTDENSTKKHKLLRGQYRGPLYGFELVELSTIPDEVIEHAQSLATELRANVEDTERDYDSERRRIKVYMNHRFRECAEYFMDTHGEKWKEEKEAIDKMKALRKYLVDELAKIDSQEQMCQ
The following text describes a protein:
Function:
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Sequence:
MKKLLREASEYLLSRGIRFPQREAEDILMDLLEISSRSALHQAKLSSEEQSLYWKRLRKRGDRCPTAYIHGKVHFLGVELQVTPQVLIPRQETEIFVEQIIGYLQMHKEKTTFYDVCCGSGCIGLAVRKHCPHVRVTLSDISPEALAIAESNARSNALAVDFLLGDLFDPFSFPADVLVCNPPYLSYKEFFESDPEVRCHEPWKALVGGVSGLEFYHRIATHIHKILVSGGVGWLEIGSTQGEDVKQIFHAKGIRGRVLKDYAQLDRFFFLENQANDAVSSGEVSGFSER
The following text describes a protein:
Function:
Overproduction of CaiE stimulates the activity of CaiB and CaiD.
Sequence:
MSYYAFEGLIPVVHPTAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLIVQAGANIQDGCIMHGYCDTDTIVGENGHIGHGAILHGCLIGRDALVGMNSVIMDGAVIGEESIVAAMSFVKAGFRGEKRQLLMGTPARAVRNVSDDELHWKRLNTKEYQDLVGRCHVSLHETQPLRQMEENRPRLQGTTDVTPKR
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mS38 is also involved in the splicing of the COX1 mRNA.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MLGRALRPGWLGITRTVVKKPSCGSYFNRTFQTAINTTMPPMQEGMLSTMMMMTATATRITGTVSEPLNGSNIVMQLDSVMRKRKKKMKKHKLRKRRKREKAERRKLSQGR
The following text describes a protein:
Function:
N-acetylglutamate synthase involved in arginine biosynthesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MFICCKAPARGFGKGTKTLSKFDNTSYASIARISTSTHRSALHTRKASSSAKERQRADREQLTRLLKESPGKRDARNFLKQFDAPKPKKGEGSTAPKAKQGTSEVVRKDPGTTRTGVNLGNLYQPTVFTREPLPEKKYEEEDKEEPLHLALVKLRQPQNLDDRTLGGIALTLSQMAQLGLSTAVVLDCAEYDSEDLPQIDGAYEKMLREQAARFVATLEEYNEPGALLIEHALGKTKEQNVIPSTVQIRGGVEVKNSFLLYPPIDDGVIPVVLPIAYDSDLKKVAVEADDVVLALIREFAGIAAHADRGAFEMSEASSGNKDLDDAERPILDRIIVLDPLGGIPSVNRADGAHVFVNLEAEYRDIKLELQRLSAAAGDEAKSKPAVSLGTGNPFSKFVEEEVATTHGGSKHHLANPAPMRHLKNLDVVQRALRILPPTSSGLILTPTEAARKAIPDDDRSTPSKNPLLHNLLTDKPMISSSLPTSPASRFLGSVSPNPPTFLKKGIPVTMVPDPRESGPWRPPSASNPSIELAEDPRINFPKLEDLINDSFRRKLDAKDYLDRIRGRVAGIIIAGDYEGGAICTWETPASLRGVKIPSQASETPDSPYWVPYLDKFAVLTSSQGSGGVSDIVWAALTRTGFPEGVVWRSRTSNPVNKWYQERSTGTWNLPGDQWTMFWTTNGVTKRWDGNEWDLGQSNSLTRWEAYVDVCNGIVPSWADGIKRAD
The following text describes a protein:
Function:
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKKMFLKFRGGGDDDGDDDNNNNDENNNNNDSNKDKMETDEQALAEERRRKRLEKFQINDEELIAAAAAQQQLQQQQQQSQQSQQQQKGNTSPVRTPNTTTTTTTTTTSPLKPVTPTPITTNKPVTPTPITTNKPVAPAPTTKDSIRQCDIPMTESNYYVLEKIFLIYLQPNNNLPEKSIYLPSVNEQIKEEIKDGQLKLDKPVLDRILVERLSTKVQGVPAVEYLISCFNRIQQTIKKKMAIDQQILKDSTELVLLYFGLVLTIPDMFQNTSSSYGIGPVQLMPYLCGETTEELTDEFIFKFLSEYQEDLTPIFEPIFLDLIKILSTTTLTGNVFPYYKVFSRLVQFKAVSDLVVTLQCWNSPNFNGKEMERNTILGSLFSPSSASDDGSTIKQYFSNASTMNKNTIGDAFISIRQIQMNIHNGLVDLLKGFLKVQQENKEAFLSWLASAVEKNLERNKLQVDRTKACSDGFALNLCAVLVLLCEAFVDIDCSKVSMVDTNFLLSGKRHDITKDTRLCATSEEADQWVKDGTIEKPLAHTNFITETFFSTLRALHIGINSTYEKLKLIGRNLQDIENNKRVLLDSKIKWQNTPQGRLFEGQLDLLTKKEDMLKGITYTIDAQLFEPTFLQKTASFLLFATNWILKVINPKNTPLPLPLPAPPQFAALPEFCIEDIVDFFTFVITNFSQVLQYIKLEQLMKFFITILATPEYVKNPYLKAKIIEIISQFVPSKYSKGNPILLECNQDVKDHMVLALMRFYVDIEFTGGHNQFYEKFSYRHYSSLILKYLWSIPDFRKKFTETPKDPIFIKFINMLINDSIYVLDEALAKLAKIKENQTLFDDPNWDKDLTPEQRKEKIEQNDLNERICKSNLSLANSNIDMMLFLSSDKTIISGFMRPELIDRISAMMNYFLALIVGPKCTNLKVREPEKYHFNPKVLLNQLTEIYVNFGRDPRFLQSVVRDGRSFKNSLFQTCEKILQRERLKNDHELDEFSKLVIKLEQVAKEEEQAEEDLGDIPDEFCDPILSTLMTDPVILPSSKTVIDRQTILRHLLSDQTDPFNRSHLTPEMLIDDVETKKKIDEWLASKKKQ
The following text describes a protein:
Function:
Serine/threonine protein kinase involved in the regulation of exocytosis. Induces phosphorylation of SEC9 and its release from the plasma membrane to the cytosol.
Subcellular Localization:
Cytoplasm.
Sequence:
MTEPMTSPAPVPAPPPEKRMQKRRSIGEWDFVKTIGAGSMGQVKLAKSRVTGELCAVKVIPKATAQHKRPPDEEAKESDISKDIRTVREAAIGKLLHHKYICEMREMYTMTNHYYMVFEYVAGGQMLDYIISHGSLKERHARKFARAIGSALDYCHQNSIVHRDLKIENILISKSGDIKLIDFGLSNLFAPNSQLKTFCGSLYFAAPELLKARPYIGPEVDVWSFGVVLYVLVCGKVPFDDKNMPLLHAKIKQGKVEYPNFLSPECKDILARMLVVNPLQRATLAEILQHPWMSRGYEGPPDSYIPYREPLTLPLDPQVVQEMSGFEFGSEAEIAQNLAALLESPEYILACHNWYKAHESSPSTSRFSFDLLKRTSGGMGGGSSDSIDLTATPMSTADPTAAYHPLISVYYLVRERLERDARREQERAGAPFVGYRQGAGSGSGSDEFGHHSGHHSGHQHSHSGHVSIPAPPTVVPPPEAAHSHHTHTHSQYSPFLSGQGPSRINVCQREAGSKTGWIRHSWHSQQREVLFGDTRQSSAQRAVHSASPSVDMAGLGVPHMPSASSNASGSHVTPHSSQDGVDGPPQTPPTRPTATFAPGSAQQPPTTTRKQYHPSARAKSMGHVRKESINTKAAAPPSESMPPVPQEFEDDVAPVQSRQHHVKMDDVDLADHTPTPSIDYPKQVFLKGFFSVQSTSTKSLPFIRSDIIRVLTQLGVRFKEIRGGFMCIHEPSLAREEDPSPGHLSPRVDTGDTSSLSPPGSPANAHWRKLSFNGRRRDHSGSGHFDFSDDFSCDSFGGSTERHHAQGGGSDMLGYTATNSSVRTPLQFEIYIVKVPILSLHGVQFKKMTGNSWQYKNLAGKILAELKL