lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKKDKRSKLEGDDLAEAQQKGSFQLPSSNETAKLDASQWPLLLKNYDKLNVRTNHYTPHVEGVSPLKRDIKNYISSGFFNLDKPSNPSSHEVVSWIKRILRCEKTGHSGTLDPKVSGCLIVCIDRTTRLAKSQQGAGKEYICIFKLHEEVEDDRKVKQALEKLTGALFQRPPLISAVKRQLRIRTVYENKFIEYDPAQQMGIFNCICESGTYVRTICVHLGLILGCGGQMQELRRNRSGICDENENMVTMHDVLDAQYLLDTQKDESYMRHIVRPLEALLTQHKRVVVKDSCINAICYGAKILIPGILRYDDDIEVGKEIVIMSTKGEAICIAIAQMNTSTIASVDHGVVAKSKRVIMERDVYGRKWGLGPVASKKKQMVKDGLLDKFGKPNDTTPKSWAKEYVQTSTKKEVKKEETPDEEEEEAPKKKSKKSKKQESSDSDSD
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MYCDSAFSKSVTEVASLLQVDVTKGLDTAQVSKRLAIHGKNELPHEPPTPLWVLVAEQFKDQLVIILLIAAAISFVLAALETQESDSSITAYVEPIVILLILVANAVVGVVQETNAEKAIEALQEYSPDEARVLRNGLLQKIDARDLVPGDIILLSVGDKVPADARLLSITSSAFKADQSILTGEPISVSKELDTVKDNQAVKQDQVNMVFSGTSITVGKASAIVVLTGSKTSIGEIHDSITSQVEEKTPLKVALDEFGEKLAKIISVICLLVWIINIRHFNDESFGGNWIKGAVYYFKIAVALAVAAIPEGLAVIITTCLALGTKKMADQGAIVRKLRSVETLGCTRVICSDKTGTLTTNQMSVRKVLVFTTSDAALELDVQGNTYGPEGLVMFEGSPIPQDFISKHPSLNELSHICAVCNDSKIVYDQPSDSFQKIGEPTEAALKALVEKLGTDDTTFNSQIPQIPDAAAISAMNSKEKLWRVSQYTRINTIEFSRDRKSMSVLVENLESKKQVLYVKGAPEQILELSDWAESDSLRVLAFATVDSPTVPAKPLMSDYMKYETNMTFVGLVGMLDPPRPEVYDAIQRCYRAGIRVIVITGDNKKTAEAICRQIGVFGINDNLTGKSFTGREFDDMTPGQKRHAALNANLFSRTEPTHKLELVNLLKTEGFVVAMTGDGVNDAPALKKADIGIAMGTGTDVAKLASDMVLVDDNFSTIVSAVEEGRSIYSNTKQFIRYLISSNIGEVVSIFLTVVLGMPEALIPVQLLWVNLVTDGLPATALGFNPSDPDIMRLPPRDSKEPIVTTWLFVRYMVIGIYVGAATVFGYAWWFMYFSAGPHISFHQLSHFHQCASLFPEIGCEMFTNVMSHKATTMSLSILVVVEMLNAINSLSENQSLLTFPLYKNLYLCGAIVLSMLLHITILYVPFFTNLFSITPLNQEEWIAVLAISAPVILIDEMLKAISRSYMVVSKPEIVKSKQE
The following text describes a protein:
Function:
Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
Sequence:
MRLYESLLEMCLNKAWEHQTLALENPSVACMVLDKNHEILSLETHKKAKTPHAEVLAAQSALKILRPSLKNDLEKLEDPKTLSDFLKTHHDNAFTDCVFLITLEPCNSYGKTPACSELLEILKPKRVVIATEENEAKKGGLARLQKARIETIICHNLENKAKDLLLPFRVMEQKGRFNLFKLALRMNGDYHHGKITGQKSVIFTHNQRAICDTLIVSGKTIRTDNPLLDARFCDSFYQNKNPNIAILSKRSIDPNSKVFSAPNRLVNTFHDPKDLPLEKGFNFIEGGWELFESLRDKIDALLLHSHASMIGEAFKALALKTPFKGRLLHAQILENEALLWIENS
The following text describes a protein:
Function:
Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8.
Subcellular Localization:
Cytoplasm.
Sequence:
MYRASSTFGVNSERNLTSQEGRAKGIRDFASTLSSFELVTTGFEHLELLKRSCIFWLEPHSGFFFPTAWREQRVGGGEMALVPYTETAEMGLQRFHKPLATFSFANHTIQIRQDWKQLGVAAVVWDAAVVLATYLEMGTVELRGCSAVELGAGTGLVGIVAALLGAHVTITDRKVALEFLKSNVQANLPPHIQPKAVVKELTWGQNLGRFSPGEFDLILGADIIYLEETFTDLLQTLEHLCSNHSVVLLACRIRYERDYNFLAMLERQFTVSKVHYDSEKDVHIYKAQRRCLREDL
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication.
Subcellular Localization:
Nucleus. Note=During early-to mid replicating trophozoite stages, colocalizes with PCNA1 and ORC1 to distinct nuclear foci which probably are DNA replication origin sites. Dissociates from PCNA1 during the late schizont stage.
Sequence:
MYKIKNNESDINSDDCNETAQECIYGFSSPKKSRKESPIFVQNNDDTCSSNNIYEKKTCSNTSASSVKKYDKKEQSLCSDINNYNKVNIEGLKINERNYDRINNSEEETNINDDNNDDNNGDYDDDNNSDDDDDNDDNNNNDDNNNDDDEDVDDFEDIKENDEYKDPTYSDIYKEAKKCNIRCENIMNSSVNKKNLEEINESDPLNSSDNSMTSSSEESCSEESDKESDKESDKDGNLYDEELNEIIEEGYFKELIPAIPHDILQAYISCLKICGFERQVQLHRLINLLGDLRDPISVIQILGLPGMGKTKVVKNFIKLTNVPFAYVNCLMAVYQSGRSAKNVIYHTILKDLSINLLNEFNEYKKINNITNYSYDPTKLVPNHVSNTDNFFSILHKLLSFKPEDILNNKRTTENIRSPSNSNNNKKKKKEQNDSTGKNSKEECNNNEDDDDDNNKNNFNNNNSNNVRFNSNTNYYKDKLYDRSVVFILDNIRYLVRTHPDLFYALTRIHEYIKGPYNDVTKANKTTRGLCIILINRSPLPDEIFDGLPQPPTVWFDSYTSEMCKNILYRLYNSMCFESLLTYNDKDLKIYYVKHNKNEFLIKRNDVILENDVIYDIWCRYVDYIINVSYKDYKSDFHELLFICSHMWPLFIKPILDGVLEPIVENMNALQRNIDTHIRVATYNHSSHFTFELIDSVFLNENNLKNKIDLSFYSKILLVGAYLASRNLPLTDKRFFNATVKGGAFTLPKKRKGKNKNESILTLLSKSIPKNFTFIRWLCLTDCLLVCFFDEQLILNSLICQQINTLIQLGFISFSSPNNLSCLVRNSLMNGVQWSGYCGSALLNTTTNFSSLTNNIFCETNNSMTYESLDPYTKLVIQVPEETIRNISKEMKIPLDELII
The following text describes a protein:
Function:
Brassicaceae-specific phytocytokine (plant endogenous peptide released into the apoplast) perceived by MIK2 in a BAK1/SERK3 and SERK4 coreceptors-dependent manner, that modulates various physiological and antimicrobial processes including growth prevention and reactive oxygen species (ROS) response regulation. Inhibits root growth. Prevents general growth and development. Exhibits antibacterial effects against Pseudomonas syringae pv. tomato DC3000, Ralstonia solanacearum, Bacillus subtilis and Agrobacterium tumefaciens, thus being an antimicrobial peptide (AMP).
Subcellular Localization:
Cell membrane. Secreted, extracellular space, apoplast. Note=The precursor of SCOOP4, PROSCOOP4, accumulates at the plasma membrane and is proteolytically cleaved to release the SCOOP4 in the apoplasm.
Sequence:
MATKTSNLGHLLLSLFILLLFILSQVGVAQAKRLQQRNKLRLDCVPLPPPPPPLRGIVKPPIASFHSASPKDKGP
The following text describes a protein:
Function:
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Domain:
Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.
Sequence:
MSSGAGSDATGAGGVHAAGSGDRAVAAAVERAKATAARNIPAFDDLPVPADTANLREGADLNNALLALLPLVGVWRGEGEGRGPDGDYRFGQQIVVSHDGGDYLNWESRSWRLTATGDYQEPGLREAGFWRFVADPYDPSESQAIELLLAHSAGYVELFYGRPRTQSSWELVTDALARSRSGVLVGGAKRLYGIVEGGDLAYVEERVDADGGLVPHLSARLSRFVG
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAEKTEISNPKLVVHDNDGDEVDLKGLFKRPFCDEFMQFCFERFEVGIWSSAMESDQKQCTDSGFKTLENKGKPLLLKELNKLWNNQHLSLPWRKGRYSASNTLLIDDTPYKALLNPPNTAIFSDTYEVEGTSDISLGAHGELRLYLEGLATADDVPSYVMEHPFGQPPITCVHPDWDFYLDIIQYLNAGSADRGEHSSKDDRLDY
The following text describes a protein:
Function:
Probably involved in transport through the plasma membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSRLNPQSQNTREHLQPPSITITRTPSQRNQERRSTLIRPDLQVNVNDRRSSYIQPLASASPQSAYLSPDTKSPASATALLPRKSSVRESIGIHVQIPVKKRKYCNDAIWLLLFLCATGGMATISYMAFTRGYYQRLLYERDSEGSLCGTSAGEVDSSRDLSGQPYIAYYNLSSTNSFRRCISSCPDLTDSFSSLICQYGMDPPDTASTSVRQALVAAGNCTLTHASTPVFNRCVPNVLFNSISKDIALTNTTAVTLWASNLVVDFNHDTFAAMLFQQIALDWWILIVSMSITLVLSYSWIFLLVIMSRFIVWATLWLVLLVAWGGSGFLLYMYISLQYYGLSPLSSTISAAGGYYTASTLLTLTCIVFIISVAISISSFFFRKTIALAIRIIIETSNSFRKLQVLSTIPLAKTGAVIFLGLYTVFIVSLLSTVGKVVTPITRTYTLHNSTYTVPTGRVFVPSIHNNYFQCYAFVWFLWLYNVVHAVGAVSVAGVIGENYFTLQKEDPDVIHQSMKSAVARVFLSHFGSTLFGSISIPLIKVINIVNWFISSTFSKVEKIEVAKTKDLFFDRWYRWLGECMISVNEKAYITMALFGHPFCESARLGVRITEQNSIRHVNFEIFE
The following text describes a protein:
Function:
The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspB is involved in transcription regulation.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MSALFLAIPLTIFVLFVLPIWLWLHYSNRSGRSELSQSEQQRLAQLADEAKRMRERIQALESILDAEHPNWRDR
The following text describes a protein:
Function:
Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats.
Subcellular Localization:
Nucleus. Cytoplasm, perinuclear region. Cell junction. Note=Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell-cell junctions and leading edges of cells (By similarity). Colocalizes with MTG8 in discrete nuclear dots. Proteolytic fragment F1 appears to remain in nucleus. Fragment F2 is exported into the cytoplasm. Fragment F2 from mutant sequences with longer poly-Gln (polyQ) tracts are additionally located to the cytoplasmic membrane and to certain organelles.
Domain:
The HX repeat motif is a specific pH-dependent interaction motif for ions and/or proteins or other biomolecules. This motif could be involved in the control of embryonic development.
Sequence:
MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGNDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLIDPLASGSHLTRIPYPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQLQAMHAQSAELQRLALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL
The following text describes a protein:
Function:
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
Sequence:
MKLKLRWKGHQRFLTRQNSLVGFIWSPLKNTFSKRNSILNNQVCFEAIKYIQRHYFSSQSHHVTYLHQSPLEKLVSNGVVNENGDLTMDSLSHQIYLLHKNRPTLPLKPTNQPTRFASVLMPLVNTSQGASLLLTQRSPNLRSHAGQMCFPGGRVEPSDGSHYYAALRETYEEIGFLPNFFTYLTTFPPLFTRDEKTEIRAYLAFSVQTSLPSLGTGEVKDLFYVPLTSFLNPKHQKISRFRNTDLLYVEFNIDKIPRIWGITAVILNMYLNSICPDALISIPKF
The following text describes a protein:
Function:
Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MNCRSPVTMVVVTCATRLELTMNNLKSAVSFSRAPLRLLLYADVENIKRLQDRVRIREWPSSVLQRVTYSLRLVEFPKKSPHNWKELFGPCASQRLFLPSMLSEEDAVLYVDSDIVFFRPVEELWSIFDNMDDMQLAGLAPDVEDYNGSVYMHNWKTRYYGRYGLNSGVILMNLTRMRAYGLESIVTNLMNKYHSVMKLPDQDLLNMVFHDDPGRLYELPCRWDVLPPDCRAPASCLGQTAASLHGTDQFFVFPGREPAYHAVFLAMKK
The following text describes a protein:
Function:
Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MGVPAFFRTLSRKYPLIISNCIEPHETNGHYLPNASLPNPNTIGDREFDCLYLDMNGLIHPCFHPEGLPPPKSEAEVLQNIENYIERLFMIVRPRQILFMAIDGPAPRAKMNQQRKRRFFAAKQAAHDRWIKYWKAQKSGETELAAELYNPDYLKNHDSNVITPGTLFFERLSKHLHGFIQRKQETDPAWGKICVILSDASVPGEGEHKIMDFVRAQRLEPQYDSNRHHVIYGLDADIIFLGLASHEPYWTILRERINEAKDLPRQNSQQKKATEEDEKMALHHQIFDAPEEKEKVDLIGPKHFDFVSLWILRQYLERDLKPRNLPPNLPWDLERAIDDFIFICYGCGNDFIPTLPGFSIAEGTVSDIICLYKNNLPRYNAYLTYNGQVDFPRFKDFMKLICDERRTGEYVFERNSLLHILCPEQRSEEIEKQVNKISQAPDPDIDQEPPTEAEEKKEERKTKNIVPHVYEGIKVTEETDLAQLKRVYYKQKFHAETKEEIAKIVTEFTRGMIWTLNYYLHGTHNWDWSYPYHSAPCSSDWDLVDVNPATYQFDRGCPFLPLWQLMAVLPPQSAHALPEKMQFLMTNEKSPIKDFYPTTFSIDLEGAKQAYKGHVLVPFIGEANTDWDKRISDVMKGTDLRLTYEEEQRNQFSPTYIFLDDEKAPGGKPPITRESPIIPMNYPVVGRLTWTRDVDDHDGTSHAYIFDLKTPDYRRDFSWMRRDVIPPPYAIEGKMGRADGTDHESFFDRGAIDFESIRAESEMPLQMPGVPQGQDYLYRERMIEKIESERRMFGGNR
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MNTAIGPTRKAKSTVTAEPVNSLFVQWLTEWYEKAKTDAHALDNMKQYPERLQSGTAAIKVKSIGPKTAERLQKKLQSHFQENPEARIEWEQAICSDSAKQLNLESKSLSNVDRSGHGPLTMTCNEQSDSIGDLNLQTSKTSRSIKPHSRFSNSTAESTNMYVPRYRSGAYAILLALYKHAPLSSVMSKQEIISSGQQYTEASFSISNSTSGQPHTAWNSMATLIKKEFVIKTGVPHRFSLTEEGISMAKLLTRLQSSSPLNSQQVQLQSSQSSTVYIELSGSEISHSDTGISDCNEPLTFEDDCFQVELDSLGDIPFLSSNTAQVGNSAANLSRQTLHKTVFSYIDCDGNMVSSRNEAGVAICGTTNLLIWMNILEQTSTVRYRVQFDLHQVTSEFLQHVKIEECMIDLDRQVRGLLHDSFAPDYSTEIPASRNQQSMLDDRLESATHTPITSYPLVTSNSSKIPATDGFVLPKTSKIQLIHFPAGSFEIHLVLDSREVVKKSNRQLFQTELAQLGVPILTRALALGDFIWVARRRIANAATSKEFEDHEIVLDSIIERKLMSDLVASIKDNRYKEQKFRLSNCGLSNITYLIEDGSGSDAEGFGMGRIRAAMTQIQVLDHFFLKRSSSALDTVAYLHCMTKFITTMNKNKDLYALRAVDVSKDTVLQMRRTVAADLKVSLDTILLSYEAYHGINTKTGAFTCGDLWIRQLMCIPGVSAEKAAVLAARFPTPLSMVKSLASIPDKKAKIAMLRSLGEGRKGVGAALALTIIEFFEADMYSK
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane during regulated or polarized secretion. Involved in polarized cell growth and organ morphogenesis. During cytokinesis, involved in cell plate initiation, cell plate maturation and formation of new primary cell wall.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MIVIVIVISDFRDIYPFIHVRMDVKTKRRNEVENGDEGEDLVLATLIANGDDLSPLVRHAFETGRPEGLLRQLNFVVKKKEAEIEDMCKTHYEEFILAVDELRGVLVDAEELKSELQSDNFKLQQVGTTLLVKLEELLESYSVKKNVTEAIKNSMNCIQVLELCVKCNNHISEGQFYPALKTVDLLEKSYMQNIPARALKLVVEKRVPSIKMHIEKKVCAIGRTASVRQRDEEILERQRKVEDLNISGADDRVYNLDVEEADDDSAMQFDLTPLYRACHIHSCMGILDQFHEYYYKNRLLQLNSDLEISSSQPFVESYQTLLAQIAGYFIVEDKVLRTAGGLLVEDQVETMWETALSKMTSMLDMQFSHMKSATHLLLIKDYVTLVGSTLRKYGYDISPLLDVLDSCRDKYHLLLLADCRQHIIDLIQNDSYEQMVIKKDVDYENHVLSFNLQTTDIMPAFPYIMPFSSMVPDACRIVRSFIKGSVDYLTHGVRTSFFDIVRKYLDKFLIEVLNETLLDAINGGNISVSQAMQIAANISVLERACDFFLRHAAQLCGSGVSVRSIDKPQASLTAKVLLKTSTDAAYVTLMSLISTQIDEYMKPLTEVNFWTSEEARPEEKDYMNNMVVYLDSILSTAQQVLPLEAMYKVGTGALEHVSNIIMTAFLSDNVKRFNANAVMYINNDLTLLDEYAEQKFYSSGLGEIYKEGSFRSCLIEAKQLLNLLSSSQPENFMNPVIREKNYYALDYKKVATICDKFKDAADGIFAGLSNKNTKQSAKKKSMDMLKKRLKDFN
The following text describes a protein:
Function:
Heme-based protein that delivers nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation (Probable). In place of heme, the heme-binding cysteine can also reversibly bind NO when it is present in high concentrations.
Miscellaneous:
MISCELLANEOUS: Has some sequence similarity to inositol phosphatases, but no inositol trisphosphate phosphatase activity is detected.
Subcellular Localization:
Secreted.
Sequence:
MKLLLSAGAALAFVLGLCAAGSPPAQLSVHTVSWNSGHERAPTNLEELLGLNSGETPDVIAVAVQGFGFQTDKPQQGPACVKNFQSLLTSKGYTKLKNTITETMGLTVYCLEKHLDQNTLKNETIIVTVDDQKKSGGIVTSFTIYNKRFSFTTSRMSDEDVTSTNTKYAYDTRLDYSKKDDPSDFLFWIGDLNVRVETNATHAKSLVDQNNIDGLMAFDQLKKAKEQKLFDGWTEPQVTFKPTYKFKPNTDEYDLSATPSWTDRALYKSGTGKTIQPLSYNSLTNYKQTEHRPVLAKFRVTL
The following text describes a protein:
Function:
Plays a critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has replication fork regression activity, unwinds stalled or blocked replication forks to make a HJ that can be resolved. Has a DNA unwinding activity characteristic of a DNA helicase with 3'-5' polarity.
Sequence:
MNVYSPITTLKGVGPKTKEQLEKCMIFNIMDLLLYFPRDYEFIDNYSKDKLLSKKVIIKVQVENIKRDIRTRTGKILTTIIFNDGEKAIVGSWFNQPYIKNYFKIGEEYVLQGSLKEYRGNLTINNAQILKNKCGEEVEERKIIPKYPLKGDLKNNLLIKLVDSVLTNIDIGENLPIWLIEKYKFLSLDKSIRTIHKPENQKELEESIRRLKFQELLAYCLKIAFLKEYLETATEGISFIVSEEINNLIEVLPFKLTNAQNKVLQEIFKDQEKEKPMNRLLQGDVGSGKTIIALISLFNVIKNGYQGVMLAPTEILAVQHYEEALKLFKDFNLNIELLIGSIKVSSKKEIKEKLKEGKIDLIIGTHALIEDDVEFYNLGMVITDEQHRFGVMQRSKMLNKGKSVDTLVMSATPIPRSLTLSLYGDLDLSIIDELPPGRQKIDTYYVNDSYRKRVYNFALKEINNGRQVYIVCPLVEEKEELNLNSVEKLYDDLKGEYFKEVEIAILHGKMKGKEKDTIMKDFKDGKIKALISTTVIEVGVNVPNATLMVIENAERFGLAQLHQLRGRVGRGKHKSYCILIARVKNDIIRKRMEIMKSSNDGFLVAEEDLKLRGGGEIFGFKQHGSSNLLLADVIEDIHLLRIANMESKKIIDSNNEEDNKIKEEVKIKIKNNSKFICFN
The following text describes a protein:
Function:
Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2.
Subcellular Localization:
Nucleus.
Sequence:
MRTSPRRPLILKRRKLSLPHQDATPCPGASEQGKAAMMKTANLPEQTLAHELEDMAPKSKADQETPGQNEGGDTLGQSLAPTMRLPSNPPQSCPEDIPGFPSGVRIMGHPTMADAQLVIIPSQSNVQSIIQALTARGKEQGGPNKYIIISSESAIQTQAWHQGPQIKEEECVNSQSEATCISKQKPTGNSRKAKHRQEEQLNASLSNIQWLGNMSSESLGQYSIKEEQEDKENQIPECAKMEEEPQSFPDPQWPLSVTERPPYSYMALIQFAINSTPRKRMTLKDIYTWIEDHFPYFKHVAKPGWKNSIRHNLSLHDMFVRESEANNKVSYWTIHPQANRCLTLDQVFKTASPMSPADNEPQKKMIPDIRKSFQSAACASNKERKMKPLLPRVNSYLIPVHFPVAQPVLLPALEPYAFGAESSDGQQSSKRVKIAPKATADDGESPKHLGLCSVKEEPDISNLKCEDLFQCKRVSSSRRKQQLLPPHSEEPELVLPESIASDSGLDTDFSFIQDASANPNQNLTSHPTQNCPSNVTQEGLLHLTHDGPSYLTQVSSSHFTQDDPCQFTKDDTFYFTQDNPIQLTQDEDYTFKTPIKEHFSKPTTSSTPSKPTDTGLLQPWESETSLPRDPVLDFSPVRIPQGSTFTPFKDNLGTLSFGDTPFKDFGIFGSPQNLLNALSPASSPLLRLESPCVSRQQKRCSKELQVGASANRSLLEGLVLDTVDDSLSKILLDISFSGMEEGNGLEVDGVWSQFLPEFK
The following text describes a protein:
Function:
Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA; Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MSRVTLAIIAFFGTALVLYWQVQQKRGGDTDDSLNNSDRPDYIIEDLRSIEFNEQGQVNSRVTAKHMEHYELKNQTDFTQPVYLVYPDQGKAKWQIRADLGRLNKETGKVVLENNVIIDAINPGEPIQTLSTSFLELDLNTMIMTSDRIIYVTGKDFNIQGQGLYADLNAQEVQLTSQVVGTYEAK
The following text describes a protein:
Function:
Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MNSSSNIIYKSFKNSKIFLNKQCIINNGLKLNKKYFTTTSTKENNNNNNNKNPKFIENNLFQKGLLTIGSAFVAFINPGRGDMVATLGEMTGGCAIKSMKQKMMLDPIGRQLLKEKPRIKESTYPLNIHLLPSTTFGGAYYRWMKEHGYSPDERTEVTLIQDEDDAYVMQRYREVHDFWHVLAGVRPDFQGEVAIKWFEFLQTGLPMNAIGSIIGPLRCSWNERNELINHMIPWAIKSSKSCVYLMNVKYEDHWEDDLNEFRAKLNFIPYKYLSDINQNKTTTINM
The following text describes a protein:
Function:
Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
Sequence:
MKNISTKESFFKFKFNNRSLYCWGAFMKLRMKPEDFIVEEIIDFNKIAGDRCYLYKLTKRNIESLKAFSYIAKKFKIPLKDIGYCGLKDRHALTTQYISIPKKYGKLSLDEPNLKLELIGESKFLLLGDLEGNRFTITVRGLKKEDIPKIKENLKYLEFGAPNYFDSQRFGSVFDKKFIAKEVIKGNYEEAVKILLTKYKKSEKKLIKDLKRFIDKNWGDWDKIWEYIKENNIKSRLYVNMVKELKKSNDYKKALSYVDDRLKKIFVAAYQSYLWNECVKELLRKYVPEEDRVYYEYECGTLMFYKKMDEEVFNILKDKKFPTIAPDIEYSGEEKEIIEEILKREGLTMEELNNIGELGKFIYSERKILSIPKNLKIGEFEEDELNKGKYKITLSYELEKGSYATIIIKRAFLGVKTKKRKR
The following text describes a protein:
Function:
Involved in pre-rRNA processing and required for the NOP58-snoRNA interaction.
Miscellaneous:
MISCELLANEOUS: Present with 2610 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MADFLLRPIKQRHRNEDKYVSVDAADGSVSKIEPIADFVIKTKLLSANGPEKLQDGRKVFINVCHSPLVPKPEVDFNARIVFPLIIQNEWEIPIITSCYRMDHDKKGQECYVWDCCINSDCSRWICDDIQLREILVEWCLESCEIRDSVVLCRDRIAFPKMKKKGAELPALEVLNDELHQDYKAKMHKIIEEEAGDPMSILRGRNDDGDDNNDPDDGTLPPLFPIENKISGAKIEEIDKNEIAHRNLKQAPAPAPAPHEQQEDVPEYEVKMKRFKGAAYKLRILIENKAPNSKPDRFSPSYNFAENILYINGKLSIPLPRDIVVNAADIKIFHIRKERTLYIYI
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Deubiquitinates H2BK143ub1 of histone H2B.
Subcellular Localization:
Nucleus.
Sequence:
MGHQRPNTRSKGKRNRGDDCADVAAEIYRNVLSTRLVTKDDVNQLYMIWKPACQGCRINTKDNPNCFCGLIPLQNGNRKSGLWQKTSEVVNALGSDPSDDCRASPETPAGLTNLGATCYANSILQCLYMNKSFREGVFSIEPDVLKQQPVLDQLARLFAKLHLYKMAFVDSAPFIRTLELDNGVQQDSHEFLTLLFSLLERCLSRSSVLKARTIVQDLFRGGVSHVTMCSKCGNESEASSKIEDFYELELNVKGLKSLDESLDDYLSVEELQGDNQYYCDSCATRVDATRSIKLRSLPAVLNFQLKRCIFLPNTTTRKKISSAFCFPEELSMTRRTSEHFQSELIYDLSAILIHKGSAANSGHYVAHIKNENTQQWWEFDDEHVSNLGCQPFGKGSSHSAVKPSQTEQLDHSSSDVIIENGNEPDAGERQASKTDVTKVKTFSSCDAYMLMYVLRRPKNCDKMPIDSSGYIVEKEACTSSEVDSHLPPHLYEEVEKLNDSYVDSCEQYKMKKESEVNCIMERRLEVRSILSKAAVQSPEEFYFWISMDWLRLWADNIVPS
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).
Sequence:
MTVLKNTVLLLKSDTTDDKYTKLLQARNFKVMAVKTLVFEYKNAAILREKLLSADKYSGILLSSPRCVSAVSQALEKRLVQELWGPKSNYTVGESTYKEALDKLGVECQGKESGNAKNLAQLIIQSKAQFTKPFLFPHGNLKTDTLKLELGRENLQIEGVLVYDTLPNPDIAQELSECTNNFTDIPEFVIYFSPSGLHSSIEYLRKLLTDRGVKIIAIGPVTELALQDLNLTVHAVAKSPTPEEVIKTLT
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MPPRKRPPPPAKAPEAPPETKPKISPPAKPIAAAPPPPKAVLSDTVLAALSQHERPIYKLVFAGGDKGMSQTEIRIKTGMPTSTLTKHLRGLTSKGVLKVVNSVHKRAEKIYMDVRIDPSPEITGGTWYRNGQLDSDAVASARRRCLDQIDKLGVATAESIHEGISRECSNLAYSTEQVRDILRTMALDREVEEVRSTGAGEFGDLRAGRVCYRRGGPVQGGMMERIPCGVCPRIDECSPDGVISPSTCVYYKKWLQMDF
The following text describes a protein:
Function:
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation. Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Domain:
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence:
MILELAVILDCKCLLCFKNMVDGLRDPRPQSILLESCCQWRFPVVSLGTGVTVCAVNSSGITSYLGYLDEGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD