lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
Subcellular Localization:
Cytoplasm. Note=May associate with membranes.
Sequence:
MGLKPSQVAALERLYRRKVPPDELITPELAARMVDITRDIRRRVGILVNRHGSVEYVIIGDERGLFIPDLSEYPLGRRLLRGLRYIHTNLRGGSFTEDDLTDLALLRFDLMAVIQVHEDDRRLAIQTASLNPSDDSAHPYRVESAEPLAAHRMDFGAFISNLERSLEKAVATDSREVAAGTERAILISVTKHPREEAEDSMDELRELARTAGVAVLDIAIQRPRQFNPRYLMGEGKMREVVIRALQLGATLLIFDQELSPAQVRSISALTELKVIDRSQLILDIFARRATSLDGKVQVELAQLKYILPRLTGRGVQMSRLMGGIGGRGPGETKLEIDRRRIRDRIAKLERELEELSRGRQQRRQKRVRAGLPIVSIVGYTNAGKSTLLNALTKSDVFTENLLFATLDTSTRRLRFPREREVIITDTVGFIRSLPASLLGAFKATLEELQDADLLLHLVDCANPRIEEQIEQVGKILEELKLGDKPRLVVFNKGDLVPELKRKAPLAFMKIRQLARRHGAITISATDRSSLEPLLLEMERRFWPDEAGQDVPSDLS
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MDSPKKPQRLQLSKSEADNGNINLPEKRSPISSRIWQEEDPTCSGEDFSMRNFCIRVQSDHELMEGSFSFDLDGDSILRARRENSVESVSHLPVQEPKHGELSFNKDYGHSDLNRWDTGKFQDKRSQECPYTTLEETSQKDNSVVCKIDPKGDEGKQHSLSTTINQQPNSDNDVAGEGHISESLLTESKATKVPEQNIEKHLDLESSTCSSQTLHEVEPDTKETPKDVPESASYRNKVNTIKEQTEVLPNPSSDESKNISPADKSSEDALTKPSRQDIETTTIHEEAPLISKEGGTSLTESNQNTNAISDQLTCRSIAVSPIVPPEGNLSFTFQTETRIPESSNIQYRTVAVSPFVLGEGSSSFSFQSGTAANIQYRSVAVSPIVPSDGSSTFTFQKGIDTQETSKLQYRSVAVSPIVPPEGSSPFTFQSGMGNLEKPNVQYRSVAVSPIVPPEGSTSFTYQSGLGTQEKPNVQYRSVAVSPFVPPDGSSSFTFQSAMGTQETSNVHYRSVAVSPIVPPEGSSSFSFQSGMGTQEHSKVQHRSVAVSPFVPTDGSSSFTFQSEHNSQPAKDQTDSSNLSKVYAFELAPPNQGAGAETRVECRSIAVSPIVPPDESTFTFQMQQILSNTAMGYQKDSLDLLSKTYSFELTPPNQDVGIQADIRAECISVAVSPIIPPDASSSFIFQSDQTQKEWTVSGYKNKPDCELLTPNNQDSSRKANTTVQYVSVAVSPIVPPDESPTFTFLAERTGQEVAGNQGRTKDGQHIDNLSETCSFELIPPNHDAVQDSRVEYKSVAVSPIVPPEESSFTFQSENKKNDSYFMTHSFAEKDGKENSNSVNVLSETYSFALKPPCQDIGVQTDNISEFVSIAVSPFVFSQSPGTFTFQAEGKHQELASKHQDQTKENRSCQIRDFGTQTDNTVQCTSIAVSPFLPTVESSFHFQTDSPCQSSLNGTCSHVVEKPVMKDAEMQVSFSAEMTSVATDPMTPIRKSPQTSYPEVQVKAKGDHPEPVREVSWDEKGMTWEVYGASMEVEVLGMAIQKHLEKQIEEHGRQKVMTPQNTRGSSVHGASFRSEGKRQPGAFRTFFHRRPHCCSGAGPAVE
The following text describes a protein:
Function:
Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient. In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body (By similarity). By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
Sequence:
MLTSPEPKGLVPFTAESLELIKNHIAKKCNEEHEEEDLKPSWGLEAGKKLPFAYGTLPQGTVSEPLEDVDPYYYVKRNTFMVLNRNRVIFRFNAVSILCTLSPLSSLRRAVIKVLVHPLFRLLILISVLTDSILMCMSNLPEWILAVENTLLGIYTFEILVKVIARGIWAGSFSFLGDLWNWLDFSVTLFELITRSSPLSSLPMFKTIRTLRILKIIPLNHGLQSIVVTLVQCLKKLLGAIALALFFLTVSSLFGMGLFMGNLKHKCVRWPQEDGNDVMYNGTGSQYHILERENFYYMEGARYALLCGNKTDAGLCPEGYMCVKEGSNPDNGFTSFDNFGWALLAMFRLMTQDYPELLYHQILYASGKIYMIFFVLISFWFAFYMASLFLGILTMAYEQEKQRASEESRDMDSKCHQTVKEFEEEHEGAEMETTQIEMKKRSPTSINTTLDILEDTALGHKEEPETSRKECPLCWYKFTKTCFIWKCSPCWIKLNEFADRIITHPLFDLFLVICIILNICFLALEHFPMSEELMSLLAIGNLVFIGIYTIEMILKIIAMHPYGYFQISWHIFDSILVVLGLTEMLLADIEEITVFILVPLIFIKLGKYAPPFKNLMRILGRALVALKDLVLLVSIFIYFSAVFGMKLFGRSYKDCVCHVDQDCQRQRWHMSDFLHAYVTVFRILCGEWIETLWECMEVAGEAWCIPFYMMVILIGNLLILYLFVALVSSFASYDATTEVSKEAKNLQLAVAWIKMVINCVLLKILCKEKTVSTEATDQTCDPSVKENISGHTLSELSNTQTFLRYKDQSSGTEKTPVTESESQSLIASPSVSETVPIASGESDIENLDNKETRSKSANGSSKEKMKQSSSSECSTVDIAISEEEEMVYEHEKSKLHKNGYERKSSAGQVSRESRNGKIWRNIRKTCCKIVENSWFECFIGLVTLLCTGTLALEDIYIDQRKTIKIFLEYGDMIFAYIFILEMLLKWVAYGFKAYFSNNWYKLDFMVVIVLCLSLIGKTREDLNPLASIKFLRALRVLSQFERMKVVLRALIKTTLPAVSVFLVCLMIWLLFSVMGVFLFAGKFYECIDPTRGERFSVFEVMNKSQCENLVFNESMPWENAKLNFDNVGNGFLSLFQVATFNGWISIMNSAIDSVGVYMQPSFEHSLHMYTYFIIFVVFGLFLPLCMLIGVIIRNFNKQKIKQGGSNIFITVKQKKQYRALKKLLYADSQKPAARPRNKFQGFICDVVTHRVFNVIIILLICFQATTIMIQNDEQSPQIETAVFWMNSLFTMLFTLECILKLTAFRCHYFTSAWNVHDFMVVVFSITGLLLPLSIGQYFVPPSLVQLLLLSRIIHVLRPGKGPKVFHDLMLPLMLSLPALLNIALLIFLVMFIYAIFGMYNFAYVKKEAGINDVSNFETFGSSMLCLFQVTTFSGWDGMLDAIFNSQWSDCDPDKINPGTQVRGDCGSPSVGIFYFVSYILISWLIIVNMYVVLIMEFLSIPSKRKNRTLSEDDFRRFFKVWNRFDPDRTQYIDSTKLSDFAAALDPPLFMAKPNKGQLVAMDLPMAAGDRIHCLDILLAFTKRVMGKDERVEKILSEIESGFMLANPFKITYEPITTTLKRKQEAVSATIIQRAYKSYRLRQSDKKIQDIPEIDDGREDPNSKGVHSGQIEEKASIQTQI
The following text describes a protein:
Function:
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.
Subcellular Localization:
Secreted.
Sequence:
MSDQGAGGQPIKSCQMRKQVGARWTAAGHRESEMASRAVSGYLLCAVALVFLMLLQGTQSVYIQYQGFQVQLESVKQLNDLVGQWVPSPGLQDQSPQPSVCHHPALPLDLRPICASKDVASIFQALRTIANDDCELCVNVACTGCS
The following text describes a protein:
Function:
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Sequence:
MLKALSTLYLNRQTPIAQFAKQITFEKWNVIKGDKVVVVSGKDSGKTGTVLRVYRKSNEVLVQGINQKFKRKAQLDDPSGSGIQQITRPLHLSKIALIDPEKGKPTKVQRGFLEDGTPVRVSKLSGAIIPKAVDPAKSPAHRHKNKVDGIKDTSPALALQVTYKGEDFSAIKAEFDSFIAEKERKEQLLWFDK
The following text describes a protein:
Function:
Required for 3' polyadenylation of the 5.8S and 25S rRNAs as a prelude to their degradation in the exosome (By similarity). Involved in the nucleolar organization to ensure faithful chromosome segregation during mitosis (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPTGFQPAESFISFGQPASPPYKGNEASSSSRKGKRKASDTPAPGEKQTKKNKKDKKKKGSKKSQPVDEPDKKDGLPGLSKKQKKALKEQEHKARKSDRKRDNSRGIEAGPRNKKEEQKAAERHAPWTELVDVDLCRDPVDLLTEEINAFYKYVSPTREEFEVRLFMIELITRTINKLWPEAEVTPFGSWQTQLYLPQGDIDLVVAHKYLSDANKQRLLAELGKAMRQANITDVVAIIARARVPIIKFVTLEGKINVDISLNQANGVTAGKIINQYLDALPGARQLILIVKYFLSQRSMNEVYTGGLGSYSVICMVISFLQLHPKLRRSEINPELNLGTLLIEFFELFGRNFNYNDVGISIRRGGFYFSKASRGWMKGQSFLLSIEDPQDKDNDISGGSFGIRQVRNTLGGAYELLSMRLFERAEEMSRNARSGRRSTSWKDKEGDDWSILGGVMGITKETLKQRNELTRIHLEGRLHHKLSIPLGADPKPFVQNYRPPPIISVPSVTDHGRGASSPPPPAESSKRNKKDVGAIMVEDDELESDDDSDSDASSYSSSDSDDSDSDPVAISPRTANSRSTSRVPRADISDTESDGIIEISQPFESSGRGRKPLGDSEPSEDEIEVLSNPPEESRYAGGKGRGKAKVKDAFRPPTPPLPGQEGQLSDLSRPPTPPLPPGEEEEEIDSDEEALRRILAESDGDLGSEDEIGKEWQGAIQVDSDSDEEEKKGRKKRKRGVRSEERRAFWAAKGGNRLGQSSGDMSD
The following text describes a protein:
Function:
Essential for ribosome biogenesis.
Sequence:
MPHRKKKPFIEKKKAVSFHLVHRSQRDPLAADETAPQRVLLPTQKIDNEERRAEQRKYGVFFDDDYDYLQHLKEPSGPSELIPSSTFSAHNRREEKEETLVIPSTGIKLPSSVFASEFEEDVGLLNKAAPVSGPRLDFDPDIVAALDDDFDFDDPDNLLEDDFILQANKATGEEEGMDIQKSENEDDSEWEDVDDEKGDSNDDYDSAGLLSDEDHMSVPGKTHGAIADHLFWSEETKSRFTEYSMTSSVMRRNEQLTLHDERFEKFYEQYDDDEIGALDNAELEGSIQVDSNRLQEVLNDYYKEKAENCVKLNTLEPLEDQDLPMNELDESEEEEMITVVLEEAKEKWDCESICSTYSNLYNHPQLIKYQPKPKQIRISSKTGIPLNVLPKKGLTAKQTERIQMINGSDLPKVSTQLRSKNESKEDKRARKQAIKEERKERRVEKKANKLAFKLEKRRQEKELLNLKKNVEGLKL
The following text describes a protein:
Function:
Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility. May be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MAPKKKPNKGGKEMQGKKIGGKKDASGTKTPELAMVEELKEFYHKQIQDLEDRLARYQRKWDELAVREKLFHQEFEQLANNKKEIVAFLKRTLNQKVDEITDLNDQLQSLEVAKDMEKDAFEAQLAQVRHEFQEIKDQLTTENIALGIKLSSLEEFRLQKEELTEKYLALEEQLHRQEGEYKEYVYNLEKKSVLDKDRLRKEIIQRVNLVATEFRKMATNQMWETTRRAILENNSVTLQLNKVSKHGVQLLQENEQLKGTQNKLCQQLEMLENTQEIMARKNIGHKKIILMLTEKCRQQRKGTEETEQLRLLLSQLEQNFQNVQRDNQTLRSEKDQLEAQLKEKQAEANRLQEELTKEQKIRANLKTVLIQATSMLQDIVHMQTEAEDGDFDVVFQLQRKELLQQLLVLLSSGVVLKTQPDMGSHQDKQPQGLSKESQRITQTSKEGAVSLLQQLSTITTYKPGDLGLVPRRPVRIPLKPQDLRPLSYITRMGICQNTNEIYPSGALKRFRKFTLPRPFLHRK
The following text describes a protein:
Function:
May be involved in cell wall biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MDLYPSRRRLSISKAIDKHTEEQIGVQEKRYRLFGAMRITEILAYFMVIFPVLLVIIVIFGQEWYDQRNGFAEASRIMQIKPEPNVTSTDDSTLQSDHDPKDSLLGGLLVSGFNKDSCMRTRPYTNAERLLKPKQIGDLDSEGCKYVWMEFSGLGNRVISIASAFLCAMLTDRVLVVKGGESSLIYYSVNPHFHGDMLKRKLIYVSSVSSLSHLYIHLAHDCNDHDKMFFCEEDQSTYYKAYLAKADERIGLQIRVFDEKKDVSPQVTKQIISCVQSQEVLPKLIKPGEEQKQPSQISKTMYWENPTVTRDVIGIHQPSQEGYQQTEKLMHNRKAWGRYVLIEFCNLKDLRREVLIY
The following text describes a protein:
Function:
Potential calcium-dependent cell-adhesion protein.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MDLLSGTYLLAVLLACIVFQSGAQEKNYTVREELPENVLIGNLLKDLNLTLDPEVPLSAPLQFKLVYKTGDVPLVRIEENTGEIFTTANRIDREKLCSGIFSENRCFYEVEVAVLPDEVFRLVKIRFLIDDINDNAPLFPSTVINISIPENTAINSRYSVPSAIDPDIGVNGIQHYELLKGQNVFGLDVIETPEGDKWPQLIVQQILDREQKDTYVMKIKVEDGGNPPRSSTAILQVTVTDVNDNRPVFKENDIEVSIPENAPVGTSVSQLHATDADLGANAQIRFSFSNQISSLAKRLFAIDNATGLITTKDVLDREEAPTHKLTVLASDGSSTPSRATVTVNVTDVNDNVPSIDTRYIINPTNGTVLLSEKAPINTKIALITVTDKDADLNGKVTCFTDHDVPFRLKPVFDNQFLLETATYLDYEATREYAIKIVASDSGKPPLNQSAMLLIKIKDENDNAPVFTQPVIGLSIPENNAPGTQLTKISATDADGGRNAEISYMLGSDAPPIFNLDRRTGVLTAVRRLDREKQDRYSFTVLARDNGIPPLQANATVTVSVLDQNDNSPAFTHNEYNFYVPENLPMYGTVGLITVTDADAGENAAVTLSILNGRDHFIIDPLTGVIRPNITFDREQQGSYTFQVKAVDAGRLQRSSTAKVTINVVDVNDNRPVFVVPSSNYSYDLVPTTAGPGSVVTKVFAVDNDTGMNAELRYSIVGGNSRGLFAIDQLTGNVTLKEKVISADHGLHRLVVKVNDLGQPESLYAIALVHLFVNETVTNGSYVQELVRRNMDAPVGQNVGDGEITPQTNDYVKIIIAIIAGTMTVILVIFVTALVRCRQTPRHKVVQKGKQSGEWVSPNQENRQIKKKKKKKKRSPKSLLLNFVTIEESKPDDPSHEHINGTLDIPVELEEQTMGKYNWATTPTTFKPDSPDLAKHYKSASPQPTFQIKPETPVPPKKHHVIQELPLDNTFVMGCDSLSKCSSSSSDPYSVSECSCQGGFKTPAPIHTRQGWKDLNGGPLGRRVGLEVGGGWGGTECRRDQIRGSPVCRWQCDTSRIDTRLRRKL
The following text describes a protein:
Function:
May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission.
Sequence:
MGSSSSTQHHFAFQNAEKAFKAAALIQRWYRRYMARLEMRRRCTWNIFQSIEYAGQQDQVKLHEFFSYLVDHFTPSSHHERDFLNRMFTEERFAQDVETEEGGDFESIEVPDSYTGPRLSFPLLPDHATALVEAFRLRQQLHARYVLNLLYETRKHLAQLPNINRVSTCYSEEVTVCGDLHGQLDDLIFIFYKNGLPSPERAYVFNGDFVDRGKDSVEVLMVLFAFMLVYPKEFHLNRGNHEDHLVNLRYGFTKEVMHKYKIHGKKILRTLQDVFCWLPLATLVDEKVLVLHGGVSDKTDLELLAKLDRHKIVSTMRCKTRKESENREEQKRKDNQTSSGQKPTPWFLPQSRSLPSSPFHLGSGFKAYKAGRSCSIPCGSPNSKELSRRGQVRRSVDLELEQCRQQAGFLGIREKGESLPLAPDADCVADGGGVLEPTPEEWKQVVDILWSDPAAQEGCKANAVRGGGCYFGPDVTERLMEKYKLQLLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQANKATHRLTMRQRISRVEESALRALRQKLFAHSSDLLVEFRKRDPDESGVITLSDWATAVESVLHLGLPWRMLRPQLVNSSADNVLEYRSWLDSLAKEQLSRENIQSSLLEKLYRNRSNLETIFRIIDSDHSGFISLDEFRQTWKLFSSHMSIDITDDGICDLARSIDFNKDGHIDINEFLEAFRLVEQSCLEGHASACLQSTDTAESGHSSPGPC
The following text describes a protein:
Function:
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MVSTFEEQLDIEYEGFHFVNVITSDDLVYHFTNQKYQKIDGSEQLLSYQYLTLQGSKISALMDDTNADNVPEQLNFDFQLFTDADKIKQVTILLPLRCYFASLHFKFDCYLYFQESEIISGQGLSQLQIAGEVQFYQQEPLPSSNFDIDYYSEIIVDDNLSNQWMGEMLSQIYTRTYSVRPRYISRKIGGNSEKQLRVSIKLDNIKLQLIQRWVSLLAIMKLAWLQYFSVFIIIWIIGREFLIFLFRFRIVDTCKVEQL
The following text describes a protein:
Function:
Permease for high affinity iron uptake.
Miscellaneous:
MISCELLANEOUS: Present with 8370 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPNKVFNVAVFFVVFRECLEAVIVISVLLSFLKQAIGEHDRALYRKLRIQVWVGVLLGFIICLAIGAGFIGAYYSLQKDIFGSAEDLWEGIFCMIATIMISMMGIPMLRMNKMQSKWRVKIARSLVEIPHRKRDYFKIGFLSRRYAMFLLPFITVLREGLEAVVFVAGAGITTQGSHASAYPLPVVVGLICGGLVGYLLYYGASKSSLQIFLILSTSILYLISAGLFSRGAWYFENYRFNLASGGDASEGGDGNGSYNIRKAVYHVNCCNPELDNGWDIFNALLGWQNTGYLSSMLCYNIYWLVLIIVLSLMIFEERRGHLPFTKNLQLKHLNPGYWIKNKKKQELTEEQKRQLFAKMENINFNEDGEINVQENYELPEQTTSHSSSQNVATDKEVLHVKADSL
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MSSSVVSSEEMAAVKTSSNGVWQGDDPLHFAFPLLILQALLILVLSRLLAFLLRPLRQPKVIAEIVAGILLGPSALGRNKAYLRALFPPWSAPVLESVASLGLLFFLFLVGLELDLRSVRRSGRRAFAIAAAGISLPFACGVGVAFVLRAAVPGADQAGYAPFLVFMGVALSITAFPVMARILAELKLLTTPIGETALAAAAFNDVAAWVLLALAVAISGSGDAAGTSQQQQHRSPVVSVWVLLCGAAFVAAWMVAVKPAMAWVARRADAAGDSSEAWVAVTLAGVLASGFATDVIGIHAIFGAFVFGLTVPKEGGFAARVTARVEDIVSELLLPLYFASSGLKTDVATVRGGEAWAMLALVIGTACAGKIVGTFGVAMACGMGAREALVLGVVMNTKGLVELIVLNIGRERKVLNEEIFAILVLMALVTTFITTPTVMAIYKPARAAGRRRLHQRKLQGPDPSAPSSPSASAGAGAAMELRVLACIHGGQDVPAVINLIETIRGHTQPRRLVKLYILRMVELTERTSSILMARAARRNGLPFLRPRRAGEPHDQVDVAFDTYAQLGHVHVRAMAAVSALHTMHDDVTAVAEDKRVSLVVLPFHKRHTGGGDDVENLGPEWRAVNRRILREAPCSVAVLVDRGFGGGEQVSSEQVAHGVCVVFFGGPDDREALELAGRMAEHPGVQVTVVRFVDGKAGSEEQSEVTLRPSHTKNADRSYTFSTAVVDAGKEKELDEAAVAEFRQRMGSLVRFEERVVVGNVIEEVVSIGKSREYGLVVVGKGRLPSAMVAQLAVVPAEHPELGPIGDALASSGHGVTSSVLVVQQHDMSNADEVPVSVVVDGRPQDGEFAKDMAEP
The following text describes a protein:
Function:
Response regulator that is part of a signal transduction pathway controlling cell differentiation in the swarmer-to-stalked cell transition; Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger.
Subcellular Localization:
Cytoplasm. Note=Phosphorylated PleD localizes to the differentiating pole.
Domain:
Activated by phosphorylation at the first response regulatory domain, which induces dimerization mediated by the two response regulatory domains and allows the two substrate-binding sites to approach each other and the condensation reaction to occur (Probable). The diguanylate cyclase activity is harbored by the GGDEF domain (By similarity).
Sequence:
MSARILVVDDIEANVRLLEAKLTAEYYEVSTAMDGPTALAMAARDLPDIILLDVMMPGMDGFTVCRKLKDDPTTRHIPVVLITALDGRGDRIQGLESGASDFLTKPIDDVMLFARVRSLTRFKLVIDELRQREASGRRMGVIAGAAARLDGLGGRVLIVDDNERQAQRVAAELGVEHRPVIESDPEKAKISAGGPVDLVIVNAAAKNFDGLRFTAALRSEERTRQLPVLAMVDPDDRGRMVKALEIGVNDILSRPIDPQELSARVKTQIQRKRYTDYLRNNLDHSLELAVTDQLTGLHNRRYMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDTFGHDIGDEVLREFALRLASNVRAIDLPCRYGGEEFVVIMPDTALADALRIAERIRMHVSGSPFTVAHGREMLNVTISIGVSATAGEGDTPEALLKRADEGVYQAKASGRNAVVGKAA
The following text describes a protein:
Function:
Plays a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Membrane.
Sequence:
MFDSPPQTSPPPPPIHTTTNRHRNINNNNNIWLEKVKLFDFYPKVDDDVPRQKSTFGGVVTVVCLLITAYLLISEIYFFTFPVREHSLKVDVTRGNRLPINIDIHFPRLVCTDITIDVVDGIDGKPIKDAAYQIVKERLDSKGVPFAKGVALAGKKGIFSSRCTECEFPKQKKGSSVFFRQKCCNSCDDLREYYRLNRIPQNFADDAPQCLIERPIQDDEGCRIYGSLQVQKMKGDFHILAGLSADESHDGHAHHVHRITKENIGRVTQFNITHHIHKFSFGDDIDGLINPLEGFGIVAQSLAVQNYYIQVVPAIYKKNDYVLETNQYSYTYDYRNVNVFNLGRIFPGIYFKYDMSPLMIEVDQTSKPIVELITSICAIGGGIFYISI
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MRLAATLLILCLASAPPGKTTNNQPLKTTPWKNLCDVYAAFKDRMAGTKLAQQKHRQLSLDMGLQQTRTQILQQSTSDAQTRRRFAVLASYLSFEAAAARKHTEGKTEPAFWNNLENAAKLLGQIKEFLTIAAGPRQANTKGCITTNDGSEATGLKQGLTELAQAHGGCKAQIGDDPTGVAANDIIDDNGLKKYETAAPAQTTTGETGCKLLTLGNNNGYVDGTSLGTGVEVAGGLLKITPTVTNERKLNDLATNPGAGSKAAIAEAWKGFSSPTTPVAGYTNKGISALKTEQHFKLAFRIVYGVTPETTEKQLQDQIDTVFGKDPANFTNNNWKLVEEYTLPKDTAGKPAGTQLKEIKEPAVLKQILSETLHDREVREQKQQAELLEAKRQLQAQNKSETAKEAAEAKCNKIDKDTECKTPCKWNAEAQDEAKKCTLSEKGQKTAEKANQEGKGAKTTNTTGNNSFVIHKAPLLPAFFLR
The following text describes a protein:
Function:
Involved in the lipid remodeling steps of GPI-anchor maturation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPISFSRLAIALGIASIILLPFAYASSGDRNPTFQHCLRGCAATYCDPSQPPIAFYLRLFGWTCAENCAYHCSHSFTDKIGPGSRYHQFYGKWAFYRLGPFQEPFSIIMSLGNLLVNLQGVSAVRRRIRSENKLRKWLVSLGFVQVNTWIWSAVFHARDKPWTERLDYFSATLTIAFTLLYSIIRILHFQTPLYTSRFLLPACVAVALLVLSHFKYILSFPLGQFPYGYHTMFNLCLGLIHNLLWVLWSFSFRFPYPTLRFGRFLSLSFPYPYPPHNPYKNPSPKESSTPAVLVGLTTLAMSLELWDFAPLFRVIDAHSLWHTATIPLTMGWWHFLMADALELEGSLMGQGGMGVGLLEEPIGRRRGGGPLERDADMPMTPTFQELDSGRVKLTSSSPSPGTRMRISPKSSEFK
The following text describes a protein:
Function:
Involved in the ornithine fermentation pathway. Catalyzes the thiolytic cleavage of 2-amino-4-ketopentanoate (AKP) with coenzyme A (CoA) to form acetyl-CoA and alanine. It is strictly specific for AKP.
Sequence:
MSKDMSYSGVMSRRNEIMKNAIGIDYTTFESGSLSFDYEKMMRETGYTLEEMQKIQYSTGVGRTPVLELRNITALARKYAAPGKGARIFIKDEAGNPSGSFKARRAANAVYHAKKLGYKGVIAATSGNYGAAVASQAAMAGLKCIIVQECYDSKGVGQPEIIEKARKCEALGAEVVQLSVGPELFYKFLSLLEETGYFNASLYTPFGIAGVETLGYELAVEFREAYGKDPDVVVCSNAGGGNLTGTARGLIKAGAQSEVVAASVNLQGLHMASDTQFNKKSFTTSHTGFGMPFATWPDRSDVPRSAARPLRYMDRYVTVNQGEVFYITETLASLEGLEKGPAGNTALAAAFSLAQEMDKDQIIVVQETEYTGAGKHIQPQLAFARDNGIDIKFGNPKEEVAGINIILPENPGMIKAVDHEMNKLRKSLIKNALANYPDAKLDDSDIDFLVKETKSDTEFVKATIKEIKG
The following text describes a protein:
Function:
Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination.
Subcellular Localization:
Secreted. Note=Secreted in plasma.
Sequence:
MSRKESAPVIPLLLLPLFLSFGRAYSCLEDPAEAYRLSGAVCRLTYPAAAVLNEKTTKVIEAAFQHARYPSMQGEKSLLLIGKVSFGLENLEIHNLSIGRSEFELVPGKGIALKISNVSAVFKGTIQYGYGSWLVNLAQSLDLEIESQIDLGINPRLYCGKGKVAADTSDCYLRFHKLRLHLQGDKEPNWLKKLFTDFITFTVKLVVKGQICKEINKLADILSDFIQDTAAHFLSDGDISVDIGVTTAPAITANYIESYHKGLTNYNNTTSALNESAFHPSQLTEDRMLFFWFSDELFNPLIAAAHHDGRFHLNVSAGELSELLKTSLSNVTVDSIQTCLAGASAELRVWSSSVPRLHTSNTGSRVTAQACGELHCGGQGPPALFFETSVLVDVTASYSDKKLFLHGSPKKISVLQAEIPSQNKVLQDEAQVSFIKEAVEKVGIPKVLSVLQVEITRLLDKQGANLFDIIDPEVLPRDGFTVTKMDFGFPHHLLVDFLQKTLQ
The following text describes a protein:
Function:
Sialomucin that may play a key role in hematopoiesis. May be involved in cell adhesion (By similarity). Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes.
Subcellular Localization:
Lysosome membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.
Sequence:
MSGSSRRLLWAATCLAVLCVSAAQPNITTLAPNVTEVPTTTTKVVPTTQMPTVLPETCASFNSCVSCVNATFTNNITCFWLHCQEANKTYCANEPLSNCSQVNRTDLCSVIPPTTPVPTNSTAKPTTRPSSPTPTPSVVTSAGTTNTTLTPTSQPERKSTFDAASFIGGIVLVLGVQAVIFFLYKFCKSKERNYHTL
The following text describes a protein:
Function:
FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein. Bacterial flagellum basal body.
Sequence:
MIMAKAAAQKASAPTIDTALLAKLTGGLTDRKTIAKIGADIGHLYSEFLPDTFHSETGIAIDVEYIGSESGLMTDLIANVGQNVAVADCSLRNWCPNFMMAVGNGFVIALMERMLGASPDSIGDPDERNLSHIELDLAAMVLGRIAGVLRSGVNAPGGFEATIDPPFNANGKSAFDEMIAGLYGVTIRMKIDIGKVSSEFSLIVPQRPLLKTSIVAPKASAQALKKQEEWMDMISQQVKRSQVTLEARIKLETLTLRTISRLVAGDVIPFQDLKQDDIGVEVSANGSKLYNCEFGKSGDRYMVRVKNNVSTDDEILRHLMG
The following text describes a protein:
Function:
Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments.
Subcellular Localization:
Cytoplasm.
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERNDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKPVILVFSVPSSCCSGLAIPGPQDQEFDIDTMHIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVITWEVLSRKQPFEEVTNPLQIMYSVSQGHRPDTNEESLPFDIPHRALMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSASSTVHLCDKKKMELSLNLSVNHGPQEESCGSSQLHKSSSSLRTSKSLSAQDNDFLSRKTEDYSVLHHCPVNHSCDSNIPAAQRATFCDHKTTPCALAIINSLSAEGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEIFMASRSPSLNLFQNKSL
The following text describes a protein:
Function:
Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell.
Domain:
Each rhs appears to consist of a highly conserved 141 kDa amino fragment followed by a highly divergent C-terminus.
Sequence:
MSGKPAARQGDMTQYGGPIVQGSAGVRIGAPTGVACSVCPGGMTSGNPVNPLLGAKVLPGETDLALPGPLPFILSRTYSSYRTKTPAPVGVFGPGWKAPSDIRLQLRDDGLILNDNGGRSIHFEPLLPGEAVYSRSESMWLVRGGKAAQPDGHTLARLWGALPPDIRLSPHLYLATNSAQGPWWILGWSERVPGAEDVLPAPLPPYRVLTGMADRFGRTLTYRREAAGDLAGEITGVTDGAGREFRLVLTTQAQRAEEARTSSLSSSDSSRPLSASAFPDTLPGTEYGPDRGIRLSAVWLMHDPAYPESLPAAPLVRYTYTEAGELLAVYDRSNTQVRAFTYDAQHPGRMVAHRYAGRPEMRYRYDDTGRVVEQLNPAGLSYRYLYEQDRITVTDSLNRREVLHTEGGAGLKRVVKKELADGSVTRSGYDAAGRLTAQTDAAGRRTEYGLNVVSGDITDITTPDGRETKFYYNDGNQLTAVVSPDGLESRREYDEPGRLVSETSRSGETVRYRYDDAHSELPATTTDATGSTRQMTWSRYGQLLAFTDCSGYQTRYEYDRFGQMTAVHREEGISLYRRYDNRGRLTSVKDAQGRETRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVSTTQGGLTRSMEYDAAGRVISLTNENGSHSVFSYDALDRLVQQGGFDGRTQRYHYDLTGKLTQSEDEGLVILWYYDESDRITHRTVNGEPAEQWQYDGHGWLTDISHLSEGHRVAVHYGYDDKGRLTGECQTVENPETGELLWQHETKHAYNEQGLANRVTPDSLPPVEWLTYGSGYLAGMKLGGTPLVEYTRDRLHRETVRSFGSMAGSNAAYELTSTYTPAGQLQSQHLNSLVYDRDYGWSDNGDLVRISGPRQTREYGYSATGRLESVRTLAPDLDIRIPYATDPAGNRLPDPELHPDSTLTVWPDNRIAEDAHYVYRHDEYGRLTEKTDRIPAGVIRTDDERTHHYHYDSQHRLVFYTRIQHGEPLVESRYLYDPLGRRMAKRVWRRERDLTGWMSLSRKPEVTWYGWDGDRLTTVQTDTTRIQTVYEPGSFTPLIRVETENGEREKAQRRSLAETLQQEGSENGHGVVFPAELVRLLDRLEEEIRADRVSSESRAWLAQCGLTVEQLARQVEPEYTPARKAHLYHCDHRGLPLALISEDGNTAWSAEYDEWGNQLNEENPHHVYQPYRLPGQQHDEESGLYYNRHRYYDPLQGRYITQDPMGLKGGWNLYQYPLNPLQQIDPMGLLQTWDDARSGACTGGVCGVLSRIIGPSKFDSTADAALDALKETQNRSLCNDMEYSGIVCKDTNGKYFASKAETDNLRKESYPLKRKCPTGTDRVAAYHTHGADSHGDYVDEFFSSSDKNLVRSKDNNLEAFYLATPDGRFEALNNKGEYIFIRNSVPGLSSVCIPYHD
The following text describes a protein:
Function:
Together with the packaging efficiency factor P6, forms the external part of the portal vertex that is embeded in the capsid and which plays critical roles in genome packaging and genome ejection. Both proteins multimerize as a single ring-shaped heterdodecamer arranged around a central channel.
Subcellular Localization:
Virion. Note=Component of the capsid. Localizes at the unique vertex of the capsid, which extends to the internal membrane via two small integral membrane proteins, P20 and P22.
Sequence:
MTIRMPNDRQRILVLGKTGTGKTCAAVWHLSQKDFKRKAWIVLNHKGDDLIDSIEGANHVDLNFRPKKPGLYIYHPIPDVDDAEVTQLLWDIHAMGDIGVYVDEGYMIPNRDPAFQALLTQGRSKKIPMIILSQRPVWLTRFAISESDFFQIFQLGDQRDRQTVQGFVPVDLEKLMQAPVNTVPALKKFHSIYYDVGANNCVIMTPVPTADAVLARFDLGKKRKQTL