lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. Upon phosphorylation by KdpD, functions as a transcription regulator by direct binding to promoter regions of target genes to positively regulate their expression.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MTLVLVIDDEPQILRALRINLTVRGYQVITASTGAGALRAAAEHPPDVVILDLGLPDMSGIDVLGGLRGWLTAPVIVLSARTDSSDKVQALDAGADDYVTKPFGMDEFLARLRAAVRRNTAAAELEQPVIETDSFTVDLAGKKVIKDGAEVHLTPTEWGMLEMLARNRGKLVGRGELLKEVWGPAYATETHYLRVYLAQLRRKLEDDPSHPKHLLTESGMGYRFEA
The following text describes a protein:
Function:
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Subcellular Localization:
Nucleus.
Sequence:
MRDTERAKDTSSEITTKDLKEKKAVVEEAENGRDTPANGNANKANGEQEADSEVDEEEEEGGEEEEEEGDGEEEDGDEDEEAEAATGKWATEDDEDDKVDTKKQKTDEDD
The following text describes a protein:
Function:
Has a role in the regulation of cell polarity, growth and division.
Subcellular Localization:
Cytoplasm.
Sequence:
MENNTASSPYTKLELVGRGSYGAVYRGICNLTKETVAIKILNLDTDEDEVSDIQKEVAVLSELKQSDVENIIKYHGSYLVGTNLWIIMDYCHGGSVRTLMEAGPISEPCISLILRETLQALKFIHHAGIIHRDIKAANILVSMSGNVKLCDFGVAAELNINRRKRITFIGTPYWMAPEVIRDGQEYNVMADIWSLGITAYEIATGSPPHAKEDPFRAVYLIAHTAPPRLNGNFSALLKEFIASCLQDVPQRRLDSSELLKSKFIKQYSRMSISELTNVVKRYDTWQAAGGIPQTLLLGEEADDGSDPDQETSDTAASDDGWEFGTIKQGQSNVSSITGTSTSTTTAATSSTTVTGTVIPKSSTVHEPPSSNDSHPLLQLFKDSKISDDDSPSNAEGASTEDSKGEVSYSQIELPSLDSSNLSSKKSTIQSKHTKQAEDYDLFVGRTRSNSKTSSDQSIKRPLPRVVQRQKTSLGKRGISMSPMKPGLRMPSSFDLQSRSISMGAFEQLSTPLEAPAHKHSAVLQPLEVNRSISIPPPKSISPSILHKPSLESASSTPKISSCSSTPKPFNSKLRAHLPPLSIGSPAVQPLANDNYDSLGVRGLNMELFNDYPGNMHNIKSVLSLEIDIVLGEMDACLKSLECNLLNRKAYNE
The following text describes a protein:
Function:
Putative oxophytodienoate reductase that may be involved in the biosynthesis or metabolism of oxylipin signaling molecules.
Sequence:
MVHAPAKEAIPLLTPYKMGQLELSHRVVLAPLTRCRSYGHVPQPHAAVYYSQRATNGGLLIAEATVISPTAQGYPDTPGIYTQQQIEAWKPIVDAVHRKGALFFLQIWHVGRVSTTDFQPNGQAPISSTDKQITPDDSGMVYSKPRRLRTDEIPQIVDDFRRAARNAIESGFDGVEIHGAHGYLLDQFMKDSANDRTDEYGGNLENRCRFAVEVIDAVVAEVGAHRVGIRLSPFDNYMDCFDSNPVALGSYMVQQLNKHPGFLYCHMVEPGMAIVEGRRKITHGLLPFRKQFNGTFIAAGGYDREEGNKVVADGYADLVAYGRLFLANPDLPRRFELDAPLNRYDRSTFYTQDPVVGYTDYPFLEEIDEESTTTYA
The following text describes a protein:
Function:
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.
Sequence:
MASYRYLYFFATILILVLPWLGLNCKAELYEGITNIQSLNNDTLDRYLVRSNRCWLVQFYSSWCGHCQSFAPTYIRLGEDVAGWKSVIALAAVDCSDVRNVPVCRRHHVDAFPTFKLVNLMSSDLSKTAIVYDGEKNIQDMRTAMVDHIIKQHWNRNLPWLHFVKFEHFRALLSNMLPIHHAAIVIFEDSHSYLGRELALDLTSNKEMIVFRVDRNKKLLSAKFHVTSYPSVYFLHRNSKIVKIAVKSNSSRKLYVKSFKNMGLISSFKLNSTNQKKTDLHNHHLPSVAAKVNIIDLDSAITFAFRRELCLKSTLNKNETLALRNFVMILSKCYPGSPRRMKFLQLLYKWMNKREYLNQISTEQITTFIDSMNASLPKKIVWSKCMGSHSHLRGYPCGLWTLFHTLMTQNCQSNFGMAMDRRKILYGVRNFVQYFFSCQKCRYHFLKEAATISSTVKSNDDAVLWLWRAHNKANSRLKDDKSTDPEFPKVQFPPLYLCPTCRLPSQSYNDSTIKWNKDNVLKFLQKFYSDIEYNENGAELPLHVNYVRAPSGSGVIQMGWDVSLMNTVDISFCIIMYLTAGVIIFYMYWYFCTRGKYRKLCKRKITY
The following text describes a protein:
Function:
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recruitment of sortins snx-1 and lst-4 and small GTPases rab-5, rab-2 and rab-7, downstream of dynamin dyn-1. The first pulse is initiated by piki-1, then maintained by vps-34 which also produces the second pulse. Required for embryonic development. Together with bec-1, involved in L3/L4 larval molting stage probably by regulating cuticle shedding. Regulates the expansion of the nucleus outer membrane. Involved in the secretion and localization of lrp-1 at the apical surface of hyp7 syncytium. May regulate endocytosis in hypodermal cells. May play a role in the formation of gut granules (a lysosome-related organelle). Plays a role in germ stem cell proliferation during larval development.
Subcellular Localization:
Nucleus outer membrane; Peripheral membrane protein. Cytoplasm. Cytoplasmic granule. Cell projection, phagocytic cup. Note=Colocalizes with rab-5 and dyn-1 at the phagocytic cup.
Sequence:
MIPGMRATPTESFSFVYSCDLQTNVQVKVAEFEGIFRDVLNPVRRLNQLFAEITVYCNNQQIGYPVCTSFHTPPDSSQLARQKLIQKWNEWLTLPIRYSDLSRDAFLHITIWEHEDDEIVNNSTFSRRLVAQSKLSMFSKRGILKSGVIDVQMNVSTTPDPFVKQPETWKYSDAWGDEIDLLFKQVTRQSRGLVEDVPWLDPFASRRIEMIRAKYKYSSPDRHVFLVLEMAAIRLGPTFYKVVYYEDETKNMRVSTSVNGGVGIVSACTRYCVADPELLLESLAEVKHSAMTRRIRDVEDERHRQVKPNKQAKDRLETIVNLPSSQVLTREQRDLVWKFRHYLRQFPKALNKYLRSVNWVHPQEVKTALALMNDWELIEAEDALELLSSAFTHPAVRAYSVSRLLEAASPEQVLLYLPQLVQALKYEQGQQLPEEGNPVPVVSEEEGKIPSVATTPTEELEGRDMTVVTKKEARKAASGDLATFLIDYALASPKVSNYLYWHLKTEIESTKESKEEHSKMYQNIQDRLMEALVKRPDTRAQVDSLHQQQIFVEDLIILMNEAKARGGRLNESKSAEFRTMLSRAKHMLDLKGVHLPLDPSFRLSSVIPDTASFFKSEMMPAKISFKVLQPNGKADRNIPEEYTVIFKTGDDLRQDQLIQQMVRLIDIILKKGQLDLKLTPYLVLSTGVGQGFVQCIKSKPLRAIQEQYKAHKMDCIREAMKELRPGDGPFGIEPNVIDNYVRSLAGYSVIMYILGLGDRHLDNLLLCENGKLFHVDFGFILGRDPKPMPPPMKLTSEMVQVMGGVKSKQFLEFVQHVDSAYRILRRHSNVLLNLFSLMLDAGIPDIAAEPDKAIFKIEQRLRLDLSDEAATKHIFTQIESSLNAKMAMISDIIHAYKQNLM
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
Subcellular Localization:
Nucleus.
Sequence:
MGIENLLNFLKPALVERCITFYRGKTAAIDAMSWLYRGCYSCAHELNQDIKTNDYLYYVQKMLIMLKEYEITPILIFDGRNLRAKEKTEQMRKQIKQQNLLKAKELQESGNTEEAKRYYQRCLKIRKQMMYTTFDVLRELEVQYIIAPYEADAQIAHMCLSGQCDFAITEDSDLICYQCPLIVFKLQSNGACFELELQKLRESRQNRAHIKSDDIRQFLAFKNEQLIDVCIMSGCDYVPSIRGMGIKKAIDYMSKYDDISNTISKLKKAKQFNGKIPEEYEKIVKATRLIFQFQTVYCPTKKQWVQLNQEKYDGFLETLEQDKFLPLDQIQQLVGERIQENLQVQFCNGDLDIKTLVFRERMKIDFTQLFKRIERRLENSKQQIVDIEAKQRVQQFLQTADIDNLPEFVEKPANVIREQQFLPAKRTQTQKEELSIFKLCEEIFDQQEKHNQQNVDELEIVQGDDENEEGMKLQQKQVQITQQNNIDDIESNESSSEFFNPFSIKSKVTNTQCLSQIKSKPTHDQSTQKKQSIKSIEKALKQTQSTIFSFVKK
The following text describes a protein:
Function:
Magnesium-dependent phosphatidate phosphatase which catalyzes the dephosphorylation of phosphatidate to yield diacylglycerol. Acts redundantly with PAH1 to repress phospholipid biosynthesis at the endoplasmic reticulum (ER). May function indirectly as repressor of multiple enzymes involved in phospholipid biosynthesis. Is involved in the pathway of galactolipid synthesis in the ER, which is required for the membrane lipid remodeling, an essential adaptation mechanism to cope with phosphate starvation.
Subcellular Localization:
Cytoplasm, cytosol.
Domain:
Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity.
Sequence:
MNAVGRIGSYIYRGVGTVSGPFHPFGGAIDIIVVEQPDGTFKSSPWYVRFGKFQGVLKNGRNLIRIDVNGVDSGFNMYLAHTGQAYFLREVEDVVGESESGEVYTLSSGDEAETTSRDDVVDKVKIPLKSRSCNYDSPSPRTGNGKIVGKPGILGYVFGGRSVRESQDCGVERAEIAADLLEVKWSTNIDTRKRGKGMSSESLDGKDYGESTSTSGKSCVEGSSEMLVDSDSILETPLVASPTLRFLDEKEQDFRESTNVEDYCEEDGSSGVVVENGLCEASSMVFSVTSEGSGNVEIFVEPRTEALAEDAVSGSDLDSKQELLRAPESVEIATLGSADQADMGSIGTSQEGSSTGSPVQDENKITIKDMHISAGDFEKSQSASGESILQPEIEEEQFSFSDLDECKPGGNSSVGSSSSDTVKVDGKESYDETKTSPEKGVENTMALSEPINIERKKDIFTDEMERLVGSLPIMRLQNNDDMDASPSQPLSQSFDPCFNTSKLDLREDESSSGGLDAESVAESSPKLKAFKHVIANPEVVELSLCKHLLSEGMGAEAASQAFNSEKLDMEKFASLGPSILENDKLVVKIGGCYFPWDAAAPIILGVVSFGTAQVFEPKGMIAVDRNEKPGDVLAQGSGSWKLWPFSLRRSTKEAEASPSGDTAEPEEKQEKSSPRPMKKTVRALTPTSEQLASLDLKDGMNSVTFTFSTNIVGTQQVDARIYLWKWNSRIVVSDVDGTITRSDVLGQFMPLVGIDWSQTGVTHLFSAVKENGYQLIFLSARAISQASVTRQFLVNLKQDGKALPDGPVVISPDGLFPSLFREVIRRAPHEFKIACLEEIRGLFPPEHNPFYAGFGNRDTDEISYLKVGIPRGKIFIINPKGEVAVNRRIDTRSYTNLHTLVNRMFPATSSSEPEDFNTWNFWKLPPPSLM
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
Subcellular Localization:
Chromosome. Cytoplasm.
Sequence:
MAETLSPSRTPGHKQRASVLSPDRPLFLGSNDDKLERAQARAARAAAIRRKPVAINQANDANPADPCLGQEQIMELFQNCIKLASENKINQKNTWELNLIDHLCDIIKVEEENDVETNFQKASCTLEAGVRIYSMRVDSVHSEAYKVLGGISRVALEAEQDTVEDGKTENMPGECTSKKEKEIKLSPLSTLESSFEALNVKKFDGSDSTEYLLFVLWAYTKTYRKNHFIFVVAFAVDPLYHQTTAQFDEGGSKGLLLNNLGVYGGCRMIFDSLEVPSKCMLSSNENKIDTIDISYTKDCIEQMASNFTKKLEISPSLKEIVNMFDEDNKRPVDTFSSSQNSIEPDHEAFEGDFNGGETENDNSGTWDFINDNQTSLNDDDTYDGDDGHFEQPDHLQENEAYVTTHDDEKSSTVDNFLFLSLGLTGKHNAWAGPEHWKYRKTKGPEEVVKENGSPLMAKSKRNKKQEPDIDFTKALESDSDLDSIFAPPKNPKTLLLPANRESVSTMLPEDCHYQPEDLVKLFLLPNVMCLGKRGRRYSDEEGEGNNNNNETFASWDNDCGQFDDGNVYNSDIEDSTTLVSQPRQVNKIEVEYDRTSKQVDVQALKEILWSSIQETHVSPQKETKELSFKEMLSAFPTDVKKQAAASIDAISPHLCFICLLHLANEHGLSIHGCDLLDDLTIYVPSI
The following text describes a protein:
Function:
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
Sequence:
MLWNSQVCQNGRASPWGFIRLICSVSLFSVLVREGAALYIQPQKARLNGGNTHNIDIGPLNRSATLTPAAYYRKVGVNGAISSDLELCNRMTVHDILLGIPGANAADAAVTMSLCIGMINFFNSGIGGGGFAVYTDGQDPERHLAFDFREMAPELAHKEMYASDPNASKIGGLAIAIPGELAGLYEMYEKRGSGVARWEELLRPVIELGFQGWAVGPALAASLQEYEAYFKAHLDDWSFVYNHKEGRVLRAGEWISRPELAKTLQNLAASGGVKPFYDAESDLVKTMVNKIQSAGGVLSESDFENYEVDVTRPLSLKIRSSWEYLPNNDLTVLTTSGSSSGAALLSALKILDQFPNKEDGDFQPEQAYQLIEAMKWMASARSRLGDFGGGEELAPQVRDVLGDAWTDYAVNLIKAGYIDGHFGTLVDWHDYLPEYELNDPHGTAHISIVDHFNNAVSLTTTVNLLFGSLVHDPSTGIVFNNEMDDFSQPGRPNAFGLQPSRYNFPEPFKRPLSSTCPTVVLNDVGLPDLVVGAAGGSRILTSVLQLIVRTYWYNMPLLEAVAYPRIHHQLLPEVLEVESLALLGPDTVDAIRRMGHSIVEVTPKSVVNAIRHWHGTWHAVSDYWRKRGISVAY
The following text describes a protein:
Function:
Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAEGSAVSDPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLYYNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDTEIRKAHMKDVVSALWVSGLDSSYLREQMLNEPLVREIVKECSNIPLSQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDIQGGEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRIANCKLFRLQLQQGLFRIRVHSP
The following text describes a protein:
Function:
Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels. When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
LSIPFLIIKLKWTTTNTIYILGMYCFSHTVRGVPATMPREGRGRLRNTWEKTDIQRKFSSCKMFCSVSSVVLYFHAFYIKYDYNHFFLNTEFVLSINIGKMLESHGFRVFGRTTY
The following text describes a protein:
Function:
Mediates the transport of acyl-CoAs and/or free fatty acids to the endoplasmic reticulum. Has no effect on the selectivity of fatty acid incorporation into triacylglycerol or further desaturation steps.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTLREGLPLFHQQFTALFKKNLLLSWRNKRATCLHLFSSFFFILLIFSIEESSKASDLTSTRHKNVTDPKALVSLPILPCEDKFFVRLPCFDFVWSGNQSRRVTDIVSAIMANNPGRPIPTNKVQSFTKPEEVDAWFMSHPSQVTGALHFVEKNATVISYGIQTNSSSEKKRGRREDPTFKFLVPLQIAAEREIARSLIGDPKFSWDFGFKEFARPAIGGEVIISAFYLMGPVFFLAFSMFGFVLQLGSVVTEKELKLREAMTTMGVYESAYWLSWLIWEGILTFVSSLFLVLFGMMFQFEFFLKNSFVLVFLLFFLFQFNMIGLAFALSSIISKSSSATTVGFLVFLVGFITQIVTTAGFPYSSAYSIGSRVIWSLFPPNTFSAGLQLLLEATSSPGDSGISWSERAICAGGESTCVITTNKIYIWLVGTFFFWFVLALYFDNIIPNASGVRKSIFYFLKPSYWTGKEGNKVEEGSICSCIGSVPPVEHITPEDEDVLEEEILVKQQAMDGRVDPNIAVQIHGLAKTYPGTTKLGCCKCTKTSPFHAVKGLWMNIAKDQLFCLLGPNGAGKTTTISCLTGINPVTGGDAKIYGNSIRSSVGMSNIRKMIGVCPQFDILWDALSSEEHLHLFASIKGLPPSSIKSIAEKLLVDVKLTGSAKIRAGSYSGGMKRRLSVAIALIGDPKLVFLDEPTTGMDPITRRHVWDIIQESKKGRAIILTTHSMEEADILSDRIGIMAKGRLRCIGTSIRLKSRFGTGFVATVSFIENKKDGAPEPLKRFFKERLKVEPTEENKAFMTFVIPHDKEQLLKGFFAELQDRESEFGIADIQLGLATLEEVFLNIARRAELESATVEGTMVTLELESGIAVEIPVGARFVGIPGTENAENPRGLMVEVYWQQDGSGSMCISGHSAEMRIPENVSVIYEPSSQVLGHGQRRVRGIVIDYESNN
The following text describes a protein:
Function:
DsRNA-binding protein that plays a role in the inhibition of host innate response. Suppresses host PACT-induced activation of RIGI and MDA5 and thereby circumvents the production of type I interferons. Also prevents the activation of host NF-kappa-B. Inhibits the integrated stress response (ISR) in the infected cell by binding to dsRNA and inhibiting EIF2AK2-mediated phosphorylation of EIF2S1/eIF2-alpha. Stress granule formation is thus inhibited, which allows protein synthesis and viral replication.
Subcellular Localization:
Host cytoplasm.
Sequence:
MDYVSLLNQIWQKYLNSPYTTCLYIPKPTAKYTPLVGTSLHPVLWNCQLSFAGYTESAVNSTKALAKQDAAQRIAWLLHKDGGIPDGCSLYLRHSSLFAQSEEEESFSN
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Sequence:
MFKDEMRQTPNKPLPIAVVGEAILKQQAIEVRDFDDTLSQLASQMAASMVEAKGVGIAAPQVHSPLALFIMASRPNERYPDAPLMEPLVVVNPQIVLRSLQLEKGEEGCLSVPGQRFTIWRPQTIVVRYQNLAGQWQHSELTGFIARIFQHEFDHLQGITLLERSQMPEQKLMAQEGKPQA
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
Miscellaneous:
MISCELLANEOUS: There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MFACSKFVSTPSLVKSTSQLLSRPLSAVVLKRPEILTDESLSSLAVSCPLTSLVSSRSFQTSAISRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTSSRATSNAKLVKHHQRQQSTALARSSANKFTLRQSQFERQREEEQVRAQQQADAPGSTSCAVGDGLLSRSGHGRGAGGYTASEMEVRDTPNPFARSRSAPASGTFSTTTRSATMGLEKMQARTTRTTRRIDRFNLTTSAGSEAAPSPSLLMGVRRVREGEGRGVAGLAAEDREEGGLAAPPAKVTRAERFREMISNSKGQRAQLQRERAERDATTVQLDAEINSLLHLLPKRNKAKEEQEAFAQSGTPEVRALLDSYRRNHQAKCLTLKSSGAFEVRTLVDAARSTTNRSAPSAQTADPTAPASATARDAAPSFLDAADRALLARVRAGAACSSEDGINEVASTAGARVGAPSMPRQAAADIAEARAMVIPGGGGRPASCDDFDLMMHTFQMDPRRAHAVDRTLTEEEEAAKSAQQTLLKEDREQVPLLHLQERDQTQLTRGEWVAQGGDIAFHMDDDAENAGADEDNVDIPSSYEGDSDADVDSDEAAVVAESELGEDEEDAAVERVSGSATLDRLFEQLEQVATSETENATSRPQRLHALLVQLHRYAAHHVVEVTKAFRFVLVEAERSFLRGTRRGGMRRSLLVYLYAISKIFPTSDYRHAVMTPFLLFLCSALMQMKLDSLEAVHSYLVLATLLLHCLKAGSGRFCAEVVVAALNVLALQLPRVALEPARYQGTVLPMPLLERTEQALLVSSAAAATLSESDDTTSQRPPYQVGLFDTTHSPERLLLCAYRLLEEVCDLHRSTPAFPVMCARPFLALDALLLRPPSSSAASAWTPSVPVRLAHEVLTVKVRDMAKHVEEHRTPLAMRTFRPRPLRQFDPLLAEREENAAKTEVRLMKRDIREDKKRLIRHLTAEATVQRRAQEKRHAITDALREKRYHNVMSQLQQQQHSMNVVESLKARAKSKSRKGLSGAPTTSSPAEAGKE
The following text describes a protein:
Function:
May be involved in cell cycle regulation by chromatin remodeling.
Subcellular Localization:
Nucleus.
Sequence:
MVDVGKWPIFTLLSPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAVSWRLLSVEHEDFLTVAESLKKEFDSPETADLKFRIDGKYIHVHKAVLKIRCEHFRSMFQSYWNEDMKEVIEIDQFSYPVYRAFLQYLYTDTVDLPPEDAIGLLDLATSYCENRLKKLCQHIIKRGITVENAFSLFSAAVRYDAEDLEEFCFKFCINHLTEVTQTAAFWQMDGPLLKEFIAKASKCGAFKN
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MKIKIKNFLFVCFLLFFLILSFRYSCEKKKLQTVDYKKKSITGRIKNKIQKYKEKKLILITDITNINERYSSFLHILNTEGNYISKIINILSPDDIHKINYCLYDGLIIILDILNDKIVEILKASYLKLFIDKKKHIFFSLNNVIGKNAVHYLNEINISVHGNSSYVNDYFNNIVIKNDDKEKEINIKKRNKQKEFFTNQIISNTPITSIKNNILFKGTAHSVLLKEKYFLEVLTCTRTCLLYDKNDQVIKRQKQGTDLLLISAIQLENNSRIVFSSSTEIFSDYFFNIHNANKQFTYELIKWNLKKSGIIRYNNFKFYKDINQDKSNNTFFINDFVNMSIDLYHLKNNFWIPYKNNNIQIQISKIHIISRTFLNTYKSINNPTYYTNFQLPKEHGIYKLQIYYLNKGYNILNLEYSIPIRTLLHYDKNKKVKFKNYPFYFYIYLSLIYFILFILIILFDNSYLGSNKEQHPKEKLQ
The following text describes a protein:
Function:
Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to and inhibits the endogenous nicotinic acetylcholine receptors (nAChR) in human rhabdomyosarcoma TE 671 cell line with an IC(50) of 346 mM. This neurotoxin is lethal to mice by intraperitoneal injection and to zebrafish by injection at the back of the dorsolateral region.
Subcellular Localization:
Secreted.
Sequence:
LICYSQMYNEIIKTCENGETTCYSKTWRDHRGTRLEKGCGCPPVKYDMIVKCCKTDRCGN
The following text describes a protein:
Function:
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
Sequence:
MHVKTGDEVLVIAGKDKGRRGKIKRALPAVNRVVVEGINIVKRHQKPRGPGRPGGIIEMEAPLHASNVMLICPSCGRASRTGKRFLEETDHKGRPRKVRYCKACDAVIDK
The following text describes a protein:
Function:
[Isoform Secreted protein ORF2]: Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry; [Isoform Capsid protein]: Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other (By similarity). Binds to the 5' end of the genomic RNA to mediate genome encapsidation (By similarity). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry (By similarity). Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (By similarity). Inhibits IFN production by blocking host IRF3 phosphorylation. The nuclear form probably modulates host gene expression.
Miscellaneous:
MISCELLANEOUS: The viral particles present in feces and bile are non-enveloped, while those in circulating blood and culture supernatants are covered with a cellular membrane (quasi-enveloped).
Subcellular Localization:
[Isoform Secreted protein ORF2]: Secreted. Note=Cotranslationally translocated into the ER (By similarity). Translation from the first AUG produces a full-length protein with a signal peptide that can direct the protein into the secretory pathway (By similarity); [Isoform Capsid protein]: Virion. Host cytoplasm. Host endoplasmic reticulum. Host Golgi apparatus. Host cell surface. Host nucleus. Note=Translation from the internal AUG codon disrupts the signal sequence, producing a cytoplasmic protein that is responsible for virion assembly (By similarity). Shuttles between cytoplasm and nucleus. This isoform is found in quasi-enveloped virions (By similarity).
Domain:
The Arginine-Rich Motif (ARM) acts as a nuclear localization signal that drives the nuclear translocation of isoform capsid protein. This motif has also been linked to the inhibition of host IRF3 phosphorylation.
Sequence:
MRPRPILLLLLMFLPMLPAPPPGQPSGRRRGRRSGGSGGGFWGDRVDSQPFAIPYIHPTNPFAPDVTAAAGAGPRVRQPARPLGSAWRDQAQRPAAASRRRPTTAGAAPLTAVAPAHDTPPVPDVDSRGAILRRQYNLSTSPLTSSVATGTNLVLYAAPLSPLLPLQDGTNTHIMATEASNYAQYRVARATIRYRPLVPNAVGGYAISISFWPQTTTTPTSVDMNSITSTDVRILVQPGIASELVIPSERLHYRNQGWRSVETSGVAEEEATSGLVMLCIHGSPVNSYTNTPYTGALGLLDFALELEFRNLTPGNTNTRVSRYSSTARHRLRRGADGTAELTTTAATRFMKDLYFTSTNGVGEIGRGIALTLFNLADTLLGGLPTELISSAGGQLFYSRPVVSANGEPTVKLYTSVENAQQDKGIAIPHDIDLGESRVVIQDYDNQHEQDRPTPSPAPSRPFSVLRANDVLWLSLTAAEYDQSTYGSSTGPVYVSDSVTLVNVATGAQAVARSLDWTKVTLDGRPLSTIQQYSKTFFVLPLRGKLSFWEAGTTKAGYPYNYNTTASDQLLVENAAGHRVAISTYTTSLGAGPVSISAVAVLAPHSVLALLEDTMDYPARAHTFDDFCPECRPLGLQGCAFQSTVAELQRLKMKVGKTREL
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MSTKNMINKGEEIIETEVSADDQKLINLFGRLNNRKHELLREKKVKQEELEKATDANDDIFLVDDEDTKFQYSMGEAFLELNKEETEEMVNSYISKLESSIEKIDQDLQDISDKHNELKVILYGKFKNSINLEE
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasm.
Sequence:
MVDAWYKRWGKGIIVNFTPLVVFAYSVLLLTSAEDLGCTPGFQQKVFHIDQPAEFIEDQAILNLTFSDCKGNDKLHYEVSSPYFKVNNDGSLVALRNVTAVGKTLFVHARTRHAEDMAELMIVGGKDIQGSSQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPEGSKFRLTGKGVDQEPKGIFRINENTGSVSVTRSLDREMIAAYQLFVETIDVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYVGHVMEGSPTGTTVMRITAFDADDPATDNALLRYNIRQQTPDRPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPATGAWRAAYTIINGNPGQSFEIHTNPQSNEGMLSVVKPLDYEISAFHTLLIKVENEDPLVPEVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTKQENISVGSVLLTVNATDPDSLQHQTIRYSIYKDPAGWLNINPINGTVDTMAVLDRESPFVHNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFIYPTVAEVCDDAKNLSVVILGASDKDLHPNTDPFKFEIHKQTVPDKVWKISKINNTHALVSLLQNLNKANYHLPIMVTDSGKPPMTNITDLRVQVCSCKNSKVDCNAAGAPHFSTTAVLLLSLFSLARKLTKAQCVHSTKTTSPEPLFSHMSFPKNLSKRKHSFFSFCLYNRECYL
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Sequence:
MKSLRLEDAVPQSGSRHRKLRVGRGHSAGQGKTSGRGMRGQKCRSGGGVRPGFEGGQIPLYMRLPKLKGFELVNPSSYTIVNLKQLRDLPADSEVNIETLLDAGILTATSGPLRVLGDGEAHVALQITAAYFTASAREKIEAAGGTCTVEA