lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Thereby plays a role in barrier function of the skin against infection. Plays a role in mammary epithelial tissue homeostasis and remodeling during and after pregnancy, potentially via its involvement in desmosome cell-cell junctions. Required for tooth enamel development via facilitating desmosome-mediated ameloblast adhesion to the stratum intermedium during the transitional stage of amelogenesis. May also play a role in downstream transcriptional regulation of other genes involved in amelogenesis such as AMBN, ENAM, MMP20 and KLK4. Plays a role as an effector in the TP53-dependent apoptotic pathway. Positively regulates apoptosis in T-helper 17 (Th17) cell populations via caspase-dependent signaling. Promotes neutrophil transepithelial migration in response to chemoattractants such as hepoxilin A3 (HXA3), N-Formylmethionyl-leucyl-phenylalanine (fMLP) and CXCL8/IL-8 (By similarity). May act as a positive regulator of endothelial cell apoptosis in response to blood flow-derived shear stress (By similarity).
Miscellaneous:
MISCELLANEOUS: May play a protective role in an experimental model of autoimmune encephalomyelitis that has similarities to human multiple sclerosis. Perp is protective against demyelination, inflammatory infiltrates in the spinal cord tissues and increased levels of pro-inflammatory markers Tnf, Il6 and Il17a in the brain. This is reflected in protection from early onset and decreased severity of experimental autoimmune encephalomyelitis.
Subcellular Localization:
Cell junction, desmosome. Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Associated with desmosomes. May translocate to the intestinal apical epithelial cell surface via sipA and sctB1/sipC-promoted exocytic translocation following infection by S. Typhimurium (By similarity).
Sequence:
MLRCGLACERCRWILPLLLLSAIAFDIIALAGRGWLQSSNHIQTSSLWWRCFDEGGGSGSYDDGCQSLMEYAWGRAAAATLFCGFIILCICFILSFFALCGPQMLVFLRVIGGLLALAAIFQIISLVIYPVKYTQTFRLHDNPAVNYIYNWAYGFGWAATIILIGCSFFFCCLPNYEDDLLGAAKPRYFYPPA
The following text describes a protein:
Function:
Catalyzes the hydrolysis of alpha-1,4 glycosidic linkages in starch, glycogen and similar oligosaccharides.
Subcellular Localization:
Secreted.
Sequence:
MKLFVLIALFGLGFAQHNPNTRDGRTAIVHLFEWRWADIAAECERFLGPKGFAGVQISPPNEHILVSSPWRPWWQRYQPISYNLCSRSGGENELRDMITRCNNVGVNVYVDAVINHMCGAGGGEGTHSSCGSWFNANNKDFPSVPYSNLDFNDGKCKTGSGNIENYGDPYQVRDCRLVGLLDLALEKDYVRGKVADFMNKLIDMGVAGFRVDACKHMWPGDLDNVYRRLNNLNTKWFPGGSRPFIFQEVIDLGGEPITTGEYVGLGRVTEFKYGARLGELFRKWNGQKLSYTKNWGEGWGFMADGNAVVFTDNHDNQRGHGAGGASILTFWDPRLYKMAVGYMLAHPYGFTRVMSSYSWDRNFVNGKDENDWIGPPSNGDGSTKPVPINPDQTCGDGWVCEHRWRQIMNMVQFRNVVNGQPHANWWDNGNNQVAFGRGNRGFIVFNNDDWALDVTLNTGLPGGTYCDVISGNKDGGSCTGKQITVGGDGRAHFYINNSEEDPFIAIHADSKL
The following text describes a protein:
Function:
Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER).
Subcellular Localization:
Cytoplasm.
Sequence:
MKEFVSMRLLPEDMFWSCRQSTLAEMKKKFAQVESAAEEPRVLCIIQDTTNSKTVNERVTLNVPASTPLKKLFEDVASKVGYVNGTFDLVWGNGDNVTDMTPIDQNSDKTILDAGFEPGKKNFLHLTDKDGEQPHIMQEESGTTEDSAQDRFIGPLPREGSVGCTNDYVSQSYSYSSVLSKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINQLYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSNQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSIFIDVEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSNDDGVDEGICLESNSAAERIAKVGSEKNSLLYELFSVMVHSGSAAGGHYYACIKSFSDDQWYSFNDQHVSKITQEDIKKTYGGSSGSRGYYSSAFASSTNAYMLIYRLKDPARNAKFLESHEYPDHIKQLVQKERELEEQEKRQREIERNTCKIKLFCMHPTKQIMMENKLEVHKDRTLKEAVGIAYKLMDLEEAVPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRRPDQIFQCYKPGEVMVKVHVVDLKTESVAPPISVRAYLNQTVSEFKQLISKATHLPAETMRVVLERCYNDLRLLTVSSKTLKAEGFFRSNKVFIESSESLDRHVAYTDSHLWKLLDRHANTIRLYVSLPEQSPGSQFRRSIYQKPSGDLGNLDEACERVKGPAGNMKSVEAILEESTEKLKSLSLQQQQQEGDNGDSSKSTEASDFENIESPSNEIDSSASVENRELENQIQISDPENLQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNVDNAPIPLANGLDSHSITSSRRSKANQGKKETWDTAEEDSGTDSEYDESGKSRGETQYMYFKSEPYTADEGSGEGQKWLMVHVDKRITLSAFKQQLEPFVGVPSSHFKVFRVYASNQEFESVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVYQLLVNEPEPCKFLLDAVFAKGMTVRQSKEELLPQLREQCGLDLTIDRFRLRKKTWKNPGTVFLDYHIYEEDINISSNWEVFLEILDGVEKMKSMSQLAVLSRRWRPSEMKLDSFQEVVLESSSVEELKEKLSELSGIPLENIEFAKGRGTFPCDISVLEIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDKTEELMELTDEQRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDLTQD
The following text describes a protein:
Function:
Involved in the regulation of the iron regulon in responss to decreased mitochondrial iron-sulfur cluster synthesis.
Miscellaneous:
MISCELLANEOUS: Present with 3237 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSKPSTSDGRAHSISHVPGTHMRGTSASHSPRPFRPCADCTCSPGLLSRQGRRASLFLRQLENSRRSSSMLLNELKGAGGGSSAGNGSVYSCDSLCAVNREVNTTDRLLKLRQEMKKHDLCCYIVPSCDEHQSEYVSLRDQRRAFISGFSGSAGVACITRDLLNFNDDHPDGKSILSTDGRYFNQARQELDYNWTLLRQNEDPITWQEWCVREALEMAKGLGNKEGMVLKIGIDPKLITFNDYVSFRKMIDTKYDAKGKVELVPVEENLVDSIWPDFETLPERPCNDLLLLKYEFHGEEFKDKKEKLLKKLNDKASSATTGRNTFIVVALDEICWLLNLRGSDIDYNPVFFSYVAINEDETILFTNNPFNDDISEYFKINGIEVRPYEQIWEHLTKITSQASSAEHEFLIPDSASWQMVRCLNTSTNANGAIAKKMTAQNFAIIHSPIDVLKSIKNDIEIKNAHKAQVKDAVCLVQYFAWLEQQLVGREALIDEYRAAEKLTEIRKTQRNFMGNSFETISSTGSNAAIIHYSPPVENSSMIDPTKIYLCDSGSQFLEGTTDITRTIHLTKPTKEEMDNYTLVLKGGLALERLIFPENTPGFNIDAIARQFLWSRGLDYKHGTGHGIGSFLNVHEGPMGVGFRPHLMNFPLRAGNIISNEPGYYKDGEYGIRIESDMLIKKATEKGNFLKFENMTVVPYCRKLINTKLLNEEEKTQINEYHARVWRTIVHFLQPQSISYKWLKRETSPL
The following text describes a protein:
Function:
Involved in cytochrome c oxidase assembly or stability.
Miscellaneous:
MISCELLANEOUS: Present with 907 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion intermembrane space. Note=Imported into the mitochondria via the mitochondrial MIA40-ERV1 machinery.
Domain:
The twin Cx9C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system and the subsequent transfer of disulfide bonds by dithiol/disulfide exchange reactions to the newly imported protein.
Sequence:
MSETGETSEYYKQALEEYKEVQEDEDPDVWDTRISKTGCYVENLALQLCHAETGDWRQCFNEMALFRKCWEKNGNRERVSTVDVDGTTSKDSEKKK
The following text describes a protein:
Function:
N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A. In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence'. Acts as a negative regulator of apoptosis. May play a role in hepatic lipid metabolism.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGRKSSKAKEKKQKRLEERAAMDAVCAKVEAANKLGDPLEAFPVFKKYDRNGLNITIECKRVSGLEQTTVDWAFELTKTNMQTLYEQSEWGWKDREKREEMTDDRAWYLVAWEECSVPVAFSHFRFDVECGDEVLYCYEVQLESKVRRKGLGKFLIQILQLMANSTQMKKVMLTVFKHNHGAYQFFREALQFEIDDSSPSMSGCCGDDCSYEILSRRTKFGDSQHSHPGGHCGGCCH
The following text describes a protein:
Function:
May be involved in regulation of tRNA subcellular distribution.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTTVPKVFAFHEFARVAEAVADHVVHAQNTALEEKEKPSSASASSSIGNGNSSGHGGLQGPSSLTNMGNSQHVFRSVSTRSLRNGSISQSKNKKIKERRFKIAISGGSLIQVLHEGLLKRRDVRWDKWDIYFADERLVPFESPESNYGQAKRQIFDMIDTEHYGEPNVYHINEALIVDPQECADDYEKALIRGFAGRDSVKLPMFDLLLLGCAPDGHIASLFPNFQESLRERFAWVIPVTNAPSGPPNRLSLTIPVICHSHQVTFVVEGATKAPVIKTIMERPEKGLPSSIVNEGAAGRVSWFVDNDALTDVMVTKKVYKFLVTNPNV
The following text describes a protein:
Function:
May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.
Sequence:
MEWPLSPISAEYKVAQVPGAVTFLCYQYSGSSKCYGPQASAPTGIDDMELKEEWQDEDFPRPLPEAVTEEELESSEYSQSASTPNTIELCGNRHLKKRLSAPSINFNLENSGESIASSEQAEQSTEDLDFDIDDLETPNSSELLDCPEFEWDDDLPKAKGMESSACSESRVTDMEDQDGRKWRIFLMGEHKVDMTAIEPYKQVISHGGYYGEGLNAVIVFASCYLPQDSIPDYQYVLNNLFRYIIGTLDLMVADDYMLVYLNGATPRCKIPPISWIKRCYQATGRRLKKNLKSVLILHPTWYVKALLAITRPFISSKFWKKVKFMSSIEDLSLEVSLEQIHIPDCIRELDKELNS
The following text describes a protein:
Function:
The surface protein (SU) attaches the virus to the host cell by binding to its receptor. Interaction with HECT ubiquitin ligases activates a thiol in a CXXC motif of the C-terminal domain, where the other Cys residue participates in the formation of the intersubunit disulfide. The activated thiol will attack the disulfide and cause its isomerization into a disulfide isomer within the motif. This leads to SU displacement and TM refolding, and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane; The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
Subcellular Localization:
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein; [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the virion surface through its binding to TM. Both proteins are thought to be concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity); [R-peptide]: Host cell membrane; Peripheral membrane protein. Note=The R-peptide is membrane-associated through its palmitate.
Domain:
The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo (By similarity); The YXXL motif is involved in determining the exact site of viral release at the surface of infected mononuclear cells and promotes endocytosis.
Sequence:
MARSTLSKPLKNKVNPRGPLIPLILLMLRGVSTASPGSSPHQVYNITWEVTNGDRETVWATSGNHPLWTWWPDLTPDLCMLAHHGPSYWGLEYQSPFSSPPGPPCCSGGSSPGCSRDCEEPLTSLTPRCNTAWNRLKLDQTTHKSNEGFYVCPGPHRPRESKSCGGPDSFYCAYWGCETTGRAYWKPSSSWDFITVNNNLTSDQAVQVCKDNKWCNPLVIRFTDAGRRVTSWTTGHYWGLRLYVSGQDPGLTFGIRLRYQNLGPRVPIGPNPVLADQQPLSKPKPVKSPSVTKPPSGTPLSPTQLPPAGTENRLLNLVDGAYQALNLTSPDKTQECWLCLVAGPPYYEGVAVLGTYSNHTSAPANCSVASQHKLTLSEVTGQGLCIGAVPKTHQALCNTTQTSSRGSYYLVAPTGTMWACSTGLTPCISTTILNLTTDYCVLVELWPRVTYHSPSYVYGLFERSNRHKREPVSLTLALLLGGLTMGGIAAGIGTGTTALMATQQFQQLQAAVQDDLREVEKSISNLEKSLTSLSEVVLQNRRGLDLLFLKEGGLCAALKEECCFYADHTGLVRDSMAKLRERLNQRQKLFESTQGWFEGLFNRSPWFTTLISTIMGPLIVLLMILLFGPCILNRLVQFVKDRISVVQALVLTQQYHQLKPIEYEP
The following text describes a protein:
Function:
Receptor for basic fibroblast growth factor.
Subcellular Localization:
Membrane; Single-pass membrane protein. Secreted, extracellular space, extracellular matrix.
Sequence:
MRKLICPRRFGARQVTCRLTYSTCRSIFLSILVLAEKRKVYPSQIPVLDHKESMGWIGLLIAWLGLSTCVVGTTPPQDCSDLFATGTRQSGTYTVGEQSPYQVYCDMSFLGGGWTVLQRRQDGSVDFAKTWEEYQQGFGDLDREFWLGLDKIHTLTIAKRNILQVELEDFDGERRFARYNTFLVGDASGNYTVSISGHTGNAGDSLTSTGNDGRDNINLRMFSTIDRDNDRNGGHCASLYSQGGYPVSCGQSFLNGKYNCHLSSVSCGDSQGVVWSSWGGRSYFLKKITIMIRPADFTGSGSPQDCADLYRDGIIESGVNAISSPRVFVYCDMRNSGGGWTMIQRRQDGSVDFAKNWAGYEQGFGNLDGEHWLGLSKQNQITGQKTYTLRVDLGDWENQSRYATYSSFSVGGSNSDYRVSISDYSGDAGDSLTSGGNRFDINGIRFSTSDNDNNPNTRTNCASSFGGGGWWFPDSCGYAFVNGRYNDSDSAEGVNWERWRGYTYSLKMTSLKLRPDDFAVCAEGTFGPNCSETCRCLRGNAYCNHVTGACFGGCTDGWAGSDCQTVPPQFLQPTPANETRKLGRAVTWTCKATGDPLPTITWWHGRDKLTVANTSQTESGVQYTESVFTINAVSFDDNGTYSCVAANIGGLEIVTFSLTVQACTSGEFGPGCFGTCHCAHGGSVCDVTTGVCSSGWCEAGWEGSNCQTACMPGEFGPNCTFTCHCASGGSVCNVTTGVCSSGGCEPGWKGSDCQTEQKTVGLPLVYIGIIAGAVAGVIAIAAAGAVVFYCRRKNNVPKQKDVPLKDIGDQPEKGGTRNEAFDSENTSTSERLSDLTTVADVQAFLIDNGLRECARAFRENDVDGTALRHLDDAMMKDLVPMVGPRARLKAVLQKLHGSTGQNLQVSLESPISTLNFWEIPRSSLKFGRRLGRGQFGEVRLGEIRNRGVTTTVAVKTLRDSASDSDKKDLLGELEILVTVGRHDNIVSLVGACTKNDPLSIVVEYAPNGCLRDWLKTNSAEEYQNQPAPASEVPIEQLIQFGIDVAAGMSHLAAMQCVHRDLAARNILLGENMVAKVSDFGLSRDIYGSEEYVKTAKVRRVRMCKI
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MQKSATNRQISCIGSMPWWVAAGPQDEQINSPNLNQIDWVGEHQKSQHVMSGTPEKEKQGAFQLSFSAEENNNSLKEINGHDHQSNSFKHFSPPQQKSYVELGLGQPMVSDVYANYPIVDHCHGLFAVYGTQPTGRAMLPFSVTTEDGPIYVNPKQYHGILRRRKMRAKEGMKNRSTKDKPYVHESRHRHACRRARGAGGRFLNTKNHENEKSKEETKKISEQLTFPCSHSSGSEVVQSDGGNLNSSKEISDCKSSNFSSSEVTSMYYNKEFDCFGINPGRPFAIHPLQNMEGSRQGGNWVTVVDGCCNLFKV
The following text describes a protein:
Function:
Transcription factor that binds to the C-box-like motif (5'-TGCTGACGTCA-3') and G-box-like motif (5'-CCACGTGGCC-3'), ABRE elements, of gene promoters involved in sugar signaling. Activated by low energy stress both at transcriptional and post-transcriptional mechanisms. Promotes dark-induced senescence and participates in the transcriptional reprogramming of amino acid metabolism during the dark-induced starvation response. Transcription activator of the mannan synthase CSLA9. Recognizes and binds to DNA-specific sequence of CSLA9 promoter.
Subcellular Localization:
Nucleus.
Sequence:
MANAEKTSSGSDIDEKKRKRKLSNRESARRSRLKKQKLMEDTIHEISSLERRIKENSERCRAVKQRLDSVETENAGLRSEKIWLSSYVSDLENMIATTSLTLTQSGGGDCVDDQNANAGIAVGDCRRTPWKLSCGSLQPMASFKT
The following text describes a protein:
Function:
Catalyzes the reduction of bound ferric iron (Fe(3+)) in a variety of iron chelators (siderophores) using NAD(P)H as the electron donor, resulting in the release of Fe(2+). Not active with uncomplexed Fe(3+). Also reduces FMN and FAD, but not riboflavin.
Sequence:
MDVEAFYKISYGLYIVTSESNGRKCGQIANTVFQLTSKPVQIAVCLNKENDTHNAVKESGAFGVSVLELETPMEFIGRFGFRKSSEFEKFDGVEYKTGKTGVPLVTQHAVAVIEAKVVKECDVGTHTLFVGEAVDAEVLKDAEVLTYADYHLMKKGKTPRTATVYFESK
The following text describes a protein:
Function:
Receptor for the MIP-3-beta chemokine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDPGKPRKNVLVVALLVIFQVCFCQDEVTDDYIGENTTVDYTLYESVCFKKDVRNFKAWFLPLMYSVICFVGLLGNGLVILTYIYFKRLKTMTDTYLLNLAVADILFLLILPFWAYSEAKSWIFGVYLCKGIFGIYKLSFFSGMLLLLCISIDRYVAIVQAVSAHRHRARVLLISKLSCVGIWMLALFLSIPELLYSGLQKNSGEDTLRCSLVSAQVEALITIQVAQMVFGFLVPMLAMSFCYLIIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITNSSCETSKQLNIAYDVTYSLASVRCCVNPFLYAFIGVKFRSDLFKLFKDLGCLSQERLRHWSSCRHVRNASVSMEAETTTTFSP
The following text describes a protein:
Function:
Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. Also required for spermatogenesis: regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4. Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation. Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Core component of cytoplasmic lattices in oocytes. In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. At the 2-cell and morular stage, still detected in the subcortex, but excluded from cell-cell contact regions. Expression largely disappears in blastocysts.
Domain:
Contrary to other WD repeat Groucho/TLE family members, does not contain any identifiable Q, GP, CcN or SP domains. Only the C-terminal WD-repeat domain is conserved.
Sequence:
MTSHRQSSDTFGGILPSTLSSRYLSIVNQLPEEFSSVVSEMMVHLENIFSLAENFFQAIERFSRTPDLLERNKMSIGVGAEGDSWPCHVSHEAPMGSAQTTENSAKEEDKQVPESAALQHPKFKSTPGPQLPTRRRFLSESDELQDPQPVWDAEPQFCQGFLIQGLWELFMDSRQKNQQEHGGEDSSQESKDSGLCDFKPEPQPRHRNSLSDSADPFLIKSPSALLDYYQEDVSRPQPETQESSGRADKFLKPLSWGSEVLESSCNQPSTALWQLERFTVPQALQKVRVLKHQELLLVVAVSSFTRHVFTCSQSGIKVWNLVNQVAEDRDPESHLKCSVQDNKVYLRTCLLSSNSRTLFAGGYNLPGVIVWDLAAPSLYEKCQLPCEGLSCQALANTKENMALAGFTDGTVRIWDLRTQEIVRNLKGPTNSARNLVVKDDNIWTGGLDACLRCWDLRMAKVSLEHLFQSQIMSLAHSPTEDWLLLGLANGQHCLFNSRKRDQVLTVDTKDNTILGLKFSPNGKWWASVGMGNFITVHSMPTGAKLFQVPEVGPVRCFDMTENGRLIITGSRDCASVYHIKY
The following text describes a protein:
Function:
Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells.
Subcellular Localization:
Nucleus.
Sequence:
MAASGVSGASGGGGGGGTEEAFMTFYSEVKQIEKRDSVLTSKNQIERLTRPGSSYFNLNPFEVLQMDPEVTDEEIKKRFRQLSILVHPDKNQDDVERAQKAFEAVDKAYKLLLDQEQKKRALDVIQAGKEYVEHTVKERKKQLKKEGKPTNVEEDDPELFKQAVYKQTMKLFAELEIKRKEREAKEMHERKRQREEEIEAQEKAKREREWQKNFEESRDGRVDSWRNIMDSGGHYVTLNGMRMMQLWCADSWSAGWWSVPQKGPHMD
The following text describes a protein:
Function:
May be involved in iron transport and iron homeostasis.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MIGTNDQNTRGGCCGSFKEYVNSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNPRLKVAQTSLVVQNVSVIVCGIILMMVFLHKIELMTMYNGWILTFCYILIISIANIANLASTATGITIQRDWIVVVAGDDRSKLAGMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISAWNLVSMCVEYFLLWKVYQKTPALALKTLPKVDETELKQLNLQKDIESKAQEGSHLMGEKDLKKYEFETEKEPGCASQIAEPFRTFRDGWISYYNQPVFLAGLGLSFLYMTVLGFDCITTGYAYTQGLSGSVLSLLMAASAITGIMGTVAFTKLRQKCGLVQTGVISGISQMACLTLCVISVFMPGSPLDLSVSPFEDIRTRLIQSEELHQMVPTDRPETSFSTGMHNLLNESYPIKEYPEMSPKPVSLISVSLLFAGVIAARIGLWAFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLVHFIMVILAPNPEAFGLLVLISVSFVVMGHMMYFRYAQKTLGNQLFVCCSDTKTVSSEAENNVSVV
The following text describes a protein:
Function:
Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
Subcellular Localization:
Cytoplasm.
Sequence:
MRISEQVWILDDDSSIRWVLEKALQGAKLSTASFAAAESLWQALEISQPRVIVSDIRMPGTDGLTLLERLQIHYPHIPVIIMTAHSDLDSAVSAYQAGAFEYLPKPFDIDEAISLVERALTHATEQSPTPVAQETQVKTPEIIGEAPAMQEVFRAIGRLSRSSISVLINGQSGTGKELVAGALHKHSPRKDKPFIALNMAAIPKDLIESELFGHEKGAFTGAANVRQGRFEQANGGTLFLDEIGDMPLDVQTRLLRVLADGQFYRVGGHSAVQVDVRIIAATHQDLEQLVLKGGFREDLFHRLNVIRIHLPPLSQRREDIPQLASHFLASAAKEIGVEAKILTKETAAKLSQLPWPGNVRQLENTCRWLTVMASGQEILPQDLPPELLKEPTSINPMAKGSQDWQSALTEWIDQKLSEGNSDLLTEVQPAFERILLETALRHTQGHKQEAAKRLGWGRNTLTRKLKELSMD
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MYIVLVEKILRVQPNVKKLYLLIRASDNNSARQRFTNEVVMSGLFNVIRERMGTIYLSSLVEDKVLPISGDISKKNMGIKNSQLREHMFKEIDIIINSAATTNFDERYDIAMNINVVGAKNVLKFAKSCKKVKMLLHVSTAYVCGKSTGILSEKLFVMGETLNKNSYLDMDKERSVIAIKFKELRAQNATAKELTIAMKELGLQRTVDSFLLAYGKGALKFYYGDPYSKLDLIPGDMVVNAILAAVITHENEHSEEVVIYHSSSSLNNPLKNSDFVLYLFHYFSKNPWTNKDGKTIKVKAPMRPFSSMASYRKHISTHYLPLLKVAKMLKFVNQVSCHRCFDKTYILMKKKIYKAIRLTELYEPYVFFFGSFDEVNTEKLRLRMKEINMDEVLNFDSRCIKWEDYFMNVHIPGAVKYLF
The following text describes a protein:
Function:
Involved in the central benzoyl-CoA catabolism. Catalyzes the addition of one molecule of water to the double bond and the hydrolytic cleavage of C-C bond in the alicyclic ring, 6-oxocyclohex-1-ene-1-carbonyl-CoA (6-OCH-CoA) to yield 3-hydroxypimelyl-CoA.
Sequence:
MARTDEIIARTAPGHLNDHNLIDREVESLCDGMVKYEKRPAKRHDGSVAEGIYNAWIILDNPKQYNSYTTDMVKAIILAFRRASVDRSVNAVVFTGVGDKAFCTGGNTKEYAEYYAGNPQEYRQYMRLFNDMVSAILGCDKAVISRVNGMRIGGGQEIGMACDFSIAQDLANFGQAGPKHGSAAIGGATDFLPLMVGCEQAMVSGTLCEPFSAHKAARLGIICDVVPALKVGGKFVANPTVVTDRYLDEYGRVVHGEFKAGAAFKEGQGQIKEGEIDLSLLDEKVESLCTKLLETFPECMTKSLEELRKPKLHAWNLNKENSRAWLALNMMNEARTGFRAFNEGTKETGREIDFVKLRQGLAKGTPWTEELIESLMPTAQK
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MEMADKFRRPGETKQQAAARFQRDLQRELLPQQRELRRETNHKEFTNLLNLLTDPERPLEDVDHLEWLRLLISGGRPFEEFASDVREFDDATACGLVWTANFVAYRCRTCGITPCMSICADCFHGGNHEGHDFNMFRSLAGGACDCGDTSVMKASGFCNRHGDDPPERKEAPPTLLFMAREIIPALLGRLLLHMRLNYTCIPTDRYMRTGDVFISAMREADAFLDLLHDLCKMGGAMRHVLTKALMDKDFYAKILEDIRSNPGSKTNESQDLYKHALNALPSPDQHVVIGATTYPGMTKDLNHLTLLEELIFWTVIYRFPQKMVTFLLNMLPENDYKELFTRTFVQHYGCIAMFLAEERAPNLLANRVVHISVQLFSNEDLALRMADEMRLLEILIKCALNQVMKTAMTCPMTGQRGKSRNRHQVVNCDNRILKGQCYWPIISDLTNIISHRSVAERFFGSPDLMALWARFLRYFMCMNLNIRELSQHVEFESNTYSTAFSAEIEACAAPMWQMTVHCKDLKASSYTMGMLLACLKELCHWLADCRLLRELHPLQVSFHLPLLRYFSNFLSQAINLQGLDFEKIKLDKGLLTRLMVFPLQIQAKLSEIFCGMWVRNGVQMKCQAMTYLQCHFCASMGDLDLYFLQVCASLLESDYVVETIFKRFHVLEWLVVDPNKPAGLLDPERVMPMLEGALQHIAMLVSIRTHLGMSEIELMRDEIVTLLCMQDRTHSHLQDKISFSYINHIPEKTGLINSNGRFDDILNEVADYRDPQTEVDGVQQGQYSPKPSVWQTEFDPLRTMLRSMQRKDFQSSLDRYTDQLKQSGRYKGSTHPWPPYQPLKPIKPIYQGVRRLLHSRSMHAAIFNILHKAIQDKNISDSVLCLCVALLNLGLQCSADFQVSDSTPPERLRTPIGSDLSSWYDSSFLVTNMTRTIDSLTIGSGDQQEQSSSKDPASDLVFDADTMLQQMLNQELSSVLETWDQSNAAAVSAVTQAGQDVEMAEDDTADEEEEIEEEEEEDEEEEEVMVAHHYFEEDMSDDDEEEEGLGAAAGGVGLPDNEVLHEGSQSVQSAIESVMEEVIEHSMVHPVDDDDDDDVGGKNVPGTSKGKASKQPITWPSTEESYSIPVGESLISLLIKLHSKQTGREGSYIPISKRTPGMEQKDCFGSGPYYIQALLDRFCSMNEAQSLAVEASCYKQDKEQAQSSSKSPVDSAAERRKKAQEAQKKLVANFASQQKRFLEKTLEKQDDDESMDQHDPGKSAAEATTSEIEYECVICGQTSPSTATKPIGQVVLMQATNVLGHRCLNDQRIPLPVGEDTSLTSMGRCWREEMQRLSTLLDSFGKERSWEAAGTGWEGGVHIQTCGHSLHLDCHQAYLTSLRGHNYQAHDLDVRRRGEFQCPLCRQLANSVLPFIPIRPSKVTSLERKKTSLNRVTHILSGKTPRSDPMFSVEMSPEQSGAIQTFINDVWRENECDDLEDMKASPDGLYPRICSIARINLELEIVSAGGNLLNHANTAQKRSCIKPLLRILDIHARQLTRGAHVAKMWTKLVTGAYANVRMAAADTGVPVLVCDPVALFLLFVFSIPQPVEKALFQCIVSTVYHLVYVQALASLSCRLPESERRAWQSSGRPLKSEKKEKDIGMAWLLSDVISQLSQTNLYQHADFVTSTSFQLYQAVWSPQTVEAALVHQCLPWLRIVALVQHYLFEEDLPKCEYPEDEFRTLAAFLCLTDPDQAQSSSGLVSAQCFKPPARREPTSIVAALCNPFCEFVKRSHSASKDLLMASPTYCLPRLLQLPPDYNSLFQRYNQQVCLMCKKKPDKPLVCLICGKLVCWGANCCKGQVKGRDVGEGITHANYCGKGTAVYLDINSSSMLLIRGERKCTWVSLYLDSHGEEDIDLKRGKPLFLCEQRHTLLEKLWRSHALDHNCKKWEWHHGGLDRRRGFPLSFLN
The following text describes a protein:
Function:
Converts chorismate to 2-amino-4-deoxychorismate (ADIC). Involved in the biosynthesis of the benzoxazolinate moiety of the enediyne antitumor antibiotic C-1027.
Sequence:
MTDQCVVSAPVRVRTRRLDVKETGALPAYRALAEHFGPDEVYLLESAAGPARDRRHQFVGFGALLSLSVTDRVVRVEGVPALRGLLLERAGALLEDGPQGLRLRTAGGLWPLLRAMRDMFDAEGSASGFRFGFLGFFGYDTARYIEDLPHLIENRPGLPDVRMVLHRGSVVTDLATGRCELLLHESPYWPGLAPETVTGLLADVEQAWPDPSADGFPASAVTDDSAPEVFANDVERCLKHIAVGDIYQVQIGHELSIRSTADPADVYQRLRGRNASPYMYLAGIDGHRLIGASPELFVRIEDGEVTMRPIAGTVPRSGADGGIAAGVRLRSDPKEIAEHTMLVDLCRNDIGRIARPNTLDVPDQLDVEGYSHVLHLVSTVVGRARVDTDAFDTIAALFPAGTMTGAPKIRAMEIIESVERSRRGLYAGALGLLDVGGYTNLALCIRTLFHHEGVYRTRASAGIVADSEPGAEWTETLAKMSATHWAVTGEELL
The following text describes a protein:
Function:
Toxic component of a type I toxin-antitoxin (TA) system. May be a toxic protein; overexpression causes cessation of growth and rapid membrane depolarization. Overexpression induces stress-response and a number of membrane protein genes.
Miscellaneous:
MISCELLANEOUS: Entirely encoded within a small RNA previously known as ryfB.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MTDCRYLIKRVIKIIIAVLQLILLFL
The following text describes a protein:
Function:
Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
Sequence:
MSAKRNEHGPQDDKLPIRMLHDRVLVRQDTGEGERRSGGGILIPATAAVGKRLAWAEVVAVGQNVRTVEPGDRVLYDPEDRAEVEVRGVGYVLMRERDLHAVAADRFEGSEDSTGLYL