lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5. Within the integrator complex, IntS6 acts as a substrate adapter for protein phosphatase 2A (PP2A).
Subcellular Localization:
Nucleus.
Sequence:
MTIILFLVDTSSSMCQKAYVNGVQKTYLDIAKGAVETFLKYRQRTQDCLGDRYMLLTFEEPPANVKAGWKENHATFMNELKNLQSHGLTSMGESLRNAFDLLNLNRMQSGIDTYGQGRCPFYLEPSVIIVITDGGRYSYRNGVHQEIILPLSNQIPGTKFTKEPFRWDQRLFSLVLRMPGNKIDERVDGKVPHDDSPIERMCEVTGGRSYRVRSHYVLNQCIESLVQKVQPGVVLQFEPMLPKEATSATAGEAAGASTISGMGISSTSGAGPAPDIVFQPVKKMIYVQKHITQKTFPIGYWPLPEPYWPDSKAITLPPRDAHPKLKVLTPAVDEPQLVRSFPVDKYEIEGCPLTLQILNKREMNKCWQVIVTNGMHGFELPFGYLKAAPNFSQVHLYVLAYNYPALLPILHDLIHKYNMSPPSDLMYKFNAYVRSIPPYYCPFLRKALVNINVPYQLLQFLLPENVDNYLSPTIANQLKHIKNTAKQDQENLCMKVYKQLKQPKPPYRQVETGKLFTGAPLRRDLVRHPLLRDIFSKLHGEIDPVENYTIVVPQPTHQSSAKSHRNPFDIPRRDLVEEIAKMRETLLRPVSLVAKDSGHCLPIAEMGNYQEYLKNKDNPLREIEPTNVRQHMFGNPYKKDKHMVMVDEADLSDVAPMKSPNGNGPGGAPPGSPSGSGSPTGPGPSSPGSSPGGGSGPGMPGMPGMGGGMSGLMLGAGGSGGSSKKLDGTSRGRKRKAGPLPRSFEFRRSSTDSRSSSSGSESSTTGSAPGSPIPGATSSISGCDSAMGADGGPSSSCFDEDSNSNSSFVSSTSEASASDSGMSNSHLDPLRISFVFIEEETSDQDTPLNGYVHNFINGISDDAETGETEAVPGGASLPGASSANEPSSIGASPAVSATPATSVIPASNGSEVCSAVAAGSSSSISSSASSPGVLYVPLNGLTTHAAYSSNLGGPSSPLDNLSSLGGAAGGGGSGLLGVSKPGSLPLANGYGHGHSSAISPPSPLSLVPLSPLGTSTPAASSSGLSSSSAYFSHNDINDASEISRILQTCHNGTSSGSSVGAGASNSNLNGNGSTESGGGVSSDDHASLGGNSFDALKRTAGTAGSTAAGNPHYYWASGLNHHNNNNSSAAGAASGSTLSNNHNHRGHNNSSPNKLEVKINSSCGSSPTHNNGGMGSPGQSLPLIFTEEQREAARLHNVELRLQIFRDIRRPGRDYSQLLEHLNLVKGDQDMQSDFVDMCIVESLRFRRHRMASSIQEWWDRKQQLTAVGTNEATPSAEQAVAKS
The following text describes a protein:
Function:
Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. May catalyze the hydrolysis of aspartate from the carboxy-terminus of target proteins. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of target proteins; [Isoform 2]: Metallocarboxypeptidase that mediates tubulin deglutamylation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSEDSEKEDYSDRTISDEDESDEDMFMKFVSEDLHRCALLTADSFGDPFFPRTTQILLEYQLGRWVPRLREPRDLYGVSSSGPLSPTRWPYHCEVIDEKVQHIDWTPSCPEPVYIPTGLETEPLYPDSKEATVVYLAEDAYKEPCFVYSRVGGNRTPLKQPVDYRDNTLMFEARFESGNLQKVVKVAEYEYQLTVRPDLFTNKHTQWYYFQVTNMRAGIVYRFTIVNFTKPASLYSRGMRPLFYSEKEAKAHHIGWQRIGDQIKYYRNNPGQDGRHYFSLTWTFQFPHNKDTCYFAHCYPYTYTNLQEYLSGINNDPVRSKFCKIRVLCHTLARNMVYILTITTPLKNSDSRKRKAVILTARVHPGETNSSWIMKGFLDYILGNSSDAQLLRDTFVFKVVPMLNPDGVIVGNYRCSLAGRDLNRNYTSLLKESFPSVWYTRNMVHRLMEKREVILYCDLHGHSRKENIFMYGCDGSDRSKTLYLQQRIFPLMLSKNCPDKFSFSACKFNVQKSKEGTGRVVMWKMGIRNSFTMEATFCGSTLGNKRGTHFSTKDLESMGYHFCDSLLDYCDPDRTKYYRCLKELEEMERHITLEKVFEDSDTPVIDITLDVESSSRGSDSSESIDSLTYLLKLTSQKKHLKTKKERNSTIASHQNARGQEVYDRGHLLQRHTQSNSDVKDTRPNEPDDYMVDYFRRQLPNQGLAHCKLRLPGSRHSPASASRVAGTTGTRHHTWLIFVFLVEMGKKIPLKGTDLYGNCFKVTSLQSPMGKQTSTWTEKTRIPTEDLHHNLKSKIKECISFQSKKTGINWTDDEKRSYKDKGIVQTQEILQYLLPIVHSTKNMQTTQIKQLFNPRTNFQIQHQLNPATCRNIKKYSTSWTAPRNHPFVIQGDVMANSSEWVQSKPHRSLESLSPLKGPKKNKHSQIWAIKNEDIKPLSSKWETASSSFGMDANVLKYKSLQAEETNQQSSKHTALHLTKNKDEQANKNDGQPTLYLKFQRES
The following text describes a protein:
Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSAGEVERLVELSGGTGGDEEEEWLYGGPWDVHVHSDLAKDLDENEVERPEEENASANPPSGIEEEAAENGVAKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKAGGRVYGNTGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITVQQGRTGNSEKEAALPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSDRSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLTSSAPSWPSLVDTTKQWDYYARREKDRDRDRERDRDRERERDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPVPEQESTEAAPAE
The following text describes a protein:
Function:
Serine protease inhibitor with activity toward trypsin. Negatively regulates the Toll signaling pathway and suppresses the expression of the antifungal peptide drosomycin. Its negative regulation of the Toll signaling pathway also results in the inhibition of the melanization immune response via the phenoloxidase (PPO1) cascade. Essential for unfolding and expansion of the wings after emergence from the pupal case. May regulate the Toll pathway by blocking the proteolysis of the Toll ligand spz.
Subcellular Localization:
Secreted.
Sequence:
MHILSISLMAVLPAIALAGLCGVEPDAGLLDQRLNLYKGQQNFAVSMLNVIRQSTPNENVFFSPYSTYHALLLAYFGSSGDTEKELAKVLHLDWADSKEVVRSAYILEKMNRKERQSKMPLEFSSADRIFFANDLHVTECARNRLAEEVQQIDFKSQTEESRKQINDWIAKQTHDQIRNMLSADEITPRTRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSPSNYSLVSMMQQKGTFLLNVDEQLRAHVLQLPYRTVFESQEKEDSSPDENSDISMVLILPPFNSNSLEDVLSRLNADSLDDSLKQAMPREIEVSLPKFEFEQRLELNPILAKMGVSKMFDESVATFDDLTSETISIGDSKHVAKIKVDEEGSTAAAATVLFTYRSARPVEPAKFECNHPFLFVIYDRTSRSILFTGIYRDPKTIKQ
The following text describes a protein:
Function:
Involved in the initial step of rubber degradation. Catalyzes the oxidative C-C cleavage of poly(cis-1,4-isoprene) in synthetic as well as in natural rubber by the addition of oxygen (O2) to the double bonds, leading to a mixture of oligonucleotide-isoprenoids with terminal keto and aldehyde groups (endo-type cleavage). The cleavage products are of different lengths, ranging from C20 (four isoprene units) to higher oligo-isoprenoids. Is not able to cleave low-molecular-weight substrate analogs with isoprenoid structure such as squalene (1,4-trans-isoprenoid), carotenoids, or alpha-tocopherol.
Subcellular Localization:
Secreted.
Sequence:
MDGFSRRRMLMTGGALGAVGALGAATRALARPLWTWSPSASVAGTGVGVDPEYVWDEEADPVLAAVIDRGEVPAVNALLKQWTRNDQALPGGLPGDLREFMEHARRMPSWADKAALDRGAQFSKTKGIYVGALYGLGSGLMSTAIPRESRAVYYSKGGADMKDRIAKTARLGYDIGDLDAYLPHGSMIVTAVKTRMVHAAVRHLLPQSPAWSQTSGGQKIPISQADIMVTWHSLATFVMRKMKQWGVRVNTADAEAYLHVWQVSAHMLGVSDEYIPATWDAANAQSKQVLDPILAHTPEGEALTEVLLGIVAELDAGLTRPLIGAFSRYTLGGEVGDMIGLAKQPVLERLIATAWPLLVAFREGLIPLPAVPAVLWTLEEALRKFVLLFLSEGRRIAIDIPDVNRPS
The following text describes a protein:
Function:
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).
Sequence:
MTPITIVARKVASIVDDYFTNDDVDLAASKLKELGPSEYNPYLIKRLVSMTMDRHDMEKEKLFIRMSSVLHKSSKNIGASNSDDAFYRYKMPKMITKIEGRGNGIKTNIVNMVDVAKSLARPASYTTKYFGCELGAQSKFDEKTGVSLVNGSHDTAKLAGLLENFIKKYVPCYCCGNPKREILITKTQMVQLKCVACGFVSDVDMRDKLTSFILKNPPEQKKNSKDKKVMTRAEEERLKEGEAADKIKKKLIKDVKKTKDKTSTKKKGNASDEDHTSPTLSHTGDKDDGSGEEDDDCFARHRRCCSATGLTSY
The following text describes a protein:
Function:
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MRLSSMWLCSLLLILKLQLSSTYPISTGLTDTDMDILKVLLSRLEESVSEQMAVDQSAPGQRDLLDSLSTEDAGDGPQPDAGLDEAEIREFLSAKNLKSVRNDSSRRSSGCFGRRMDRIGSMSSLGCNTVGRYNPKQR
The following text describes a protein:
Function:
Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways.
Subcellular Localization:
Secreted.
Sequence:
MQYIHLSVCGILWMLLPVCQGRAIKADRVKNDAKMLARTLITRIQEHPIQFLFPSNLKINGLDFIPDEQVLESLESMDETLEVFQKIFSSLPLENVDQMLSDMENLRSLLQLLGNIMGCTTRKPTQCDTQVNLTEEYAKAPYTTEKVALDRLQKSLHSIVKHLDHITDC
The following text describes a protein:
Function:
This protein, a dose-dependent mitotic inducer, appears to function as a negative regulator of mitosis inhibitor wee1 by phosphorylating and inactivating it.
Sequence:
MVKRHKNTIGVWRLGKTLGTGSTSCVRLAKHAKTGDLAAIKIIPIRYASIGMEILMMRLLRHPNILRLYDVWTDHQHMYLALEYVPDGELFHYIRKHGPLSEREAAHYLSQILDAVAHCHRFRFRHRDLKLENILIKVNEQQIKIADFGMATVEPNDSCLENYCGSLHYLAPEIVSHKPYRGAPADVWSCGVILYSLLSNKLPFGGQNTDVIYNKIRHGAYDLPSSISSAAQDLLHRMLDVNPSTRITIPEVFSHPFLMGCTSLSSMDSTTPPTPSLSIDEIDPLVVDCMCVLWKKSSSKKVVRRLQQRDDNDEKYVYKVLSEILRDDMLKKQRFDENKYLSLYDLIHDNNLFTKASISTTSLVKSNVSTNSRKSSNFEDELARRVSSPLSALNQMSQSPIPIRVSSDKDYDSYACHEVVSNPSTLDDDYNYMFVCPPEEYTYSTDNVRTDSLDLQSLPTPTLEQLESVPFNRYGYVRIFPSTTLSSTASGYYTPDSLSTPEPSIDGLTNLDDVQVGGFVQGSGNQNRRPISFPVISNMQPNITNVRSASAPLCSSPVPSRRYSQYATNARYTPRKVSSGSVLRKISSFFRKD
The following text describes a protein:
Function:
Transcription factor that binds 5'-AACGG-3' motifs in gene promoters. Involved in the regulation of cytokinesis, probably via the activation of several G2/M phase-specific genes transcription (e.g. KNOLLE). Required for the maintenance of diploidy; Involved in transcription regulation during induced endoreduplication at the powdery mildew (e.g. G.orontii) infection site, thus promoting G.orontii growth and reproduction.
Subcellular Localization:
Nucleus.
Sequence:
MEAESSTPQERIPKLRHGRTSGPARRSTRGQWTAEEDEILRKAVHSFKGKNWKKIAEYFKDRTDVQCLHRWQKVLNPELVKGPWTKEEDEMIVQLIEKYGPKKWSTIARFLPGRIGKQCRERWHNHLNPAINKEAWTQEEELLLIRAHQIYGNRWAELTKFLPGRSDNGIKNHWHSSVKKKLDSYMSSGLLDQYQAMPLAPYERSSTLQSTFMQSNIDGNGCLNGQAENEIDSRQNSSMVGCSLSARDFQNGTINIGHDFHPCGNSQENEQTAYHSEQFYYPELEDISVSISEVSYDMEDCSQFPDHNVSTSPSQDYQFDFQELSDISLEMRHNMSEIPMPYTKESKESTLGAPNSTLNIDVATYTNSANVLTPETECCRVLFPDQESEGHSVSRSLTQEPNEFNQVDRRDPILYSSASDRQISEATKSPTQSSSSRFTATAASGKGTLRPAPLIISPDKYSKKSSGLICHPFEVEPKCTTNGNGSFICIGDPSSSTCVDEGTNNSSEEDQSYHVNDPKKLVPVNDFASLAEDRPHSLPKHEPNMTNEQHHEDMGASSSLGFPSFDLPVFNCDLLQSKNDPLHDYSPLGIRKLLMSTMTCMSPLRLWESPTGKKTLVGAQSILRKRTRDLLTPLSEKRSDKKLEIDIAASLAKDFSRLDVMFDETENRQSNFGNSTGVIHGDRENHFHILNGDGEEWSGKPSSLFSHRMPEETMHIRKSLEKVDQICMEANVREKDDSEQDVENVEFFSGILSEHNTGKPVLSTPGQSVTKAEKAQVSTPRNQLQRTLMATSNKEHHSPSSVCLVINSPSRARNKEGHLVDNGTSNENFSIFCGTPFRRGLESPSAWKSPFYINSLLPSPRFDTDLTIEDMGYIFSPGERSYESIGVMTQINEHTSAFAAFADAMEVSISPTNDDARQKKELDKENNDPLLAERRVLDFNDCESPIKATEEVSSYLLKGCR
The following text describes a protein:
Function:
Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding (By similarity).
Sequence:
MSSIEEIDTDETFTSDYVSARKDEVDDIITATTIAQKKMENSILEKLNSTENGNIIEKKKILNFLMNGIEKIPMSHQGLDSSKVWISFWILNGMDMLDSLDSYPNISSRASKYLSILQNDDNNGNNNNRENNQNGGGFGGGNSHTSHVVSTFAAVSALYVIGTEESYKTIDREAMYKFLMRMKTKEGAFTSEDGGEYDSRTTYCAIAVASMLNILTAELERGVVDFLLSCQTYEGGFGAYPFNEAHGGYTFCSVAALSILNSLHKIDMNSLHRWITYRQSNDGGFEGRTNKLVDTCYSYWQGAVYIIIQSYFNYYKKQQQDDGDGKEGDQQEEGLLFNQAKLQEYVIRFCQQSDKKYSGFSDHPHRGKDYYHTCYGLSGISLSQYNEIGKAIQSLNTFTNTFEQPSPPINKKSTNVFTISNNNNNNNNKNNNSDDNNNNSNNNNNNSENQLVEPVHPIYNIKLSKCEKGFEIDLFLFQKEFKDASVSLGTLFFYAKFILK
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MASRDFLGRFGGEKGASSDKAGGGAGEPDEVVELSLGLSLGGCFGANSGRDAKKPRLVRSSSLAAMCSLPGTSDDIAAATPPPAPLMRTSSLPTETEEERWRRREMQSLKRLQAKRKRLERRTSMNSGKSGGSSSRDDAQEPLYPSAFQLRRSVVDQGNASSSMPEQGSGDGAEAKSTSSMEISSDNNNQNKSLPPPAPSTAGKLPNGIVKEQPPLRTLRSLTMRTTSTGDLRKSMMEDMPMVSSKVDGPNGKKIDGFLYKYRKGEEVRIVCVCHGNFLTPAEFVKHAGGGDVTNPLRHIVVNPSPSVFL
The following text describes a protein:
Function:
Catalyzes the formation of a covalent CysO-cysteine adduct via a sulfur transfer, using the thiocarboxylated sulfur carrier protein CysO-COSH as sulfur donor and O-phospho-L-serine (OPS) as sulfur acceptor. Can also use sodium sulfide as sulfur donor in vitro, albeit with less efficiency, but not thiosulfate or thio-nitro-benzoate. O-acetylserine (OAS) is a very poor substrate in comparison with OPS. May be of particular importance for cysteine biosynthesis in the persistent phase of M.tuberculosis.
Domain:
The five C-terminal amino acid residues are inserted into the active site cleft in the closed conformation, protect the aminoacrylate intermediate and are involved in sulfur donor selectivity.
Sequence:
MTRYDSLLQALGNTPLVGLQRLSPRWDDGRDGPHVRLWAKLEDRNPTGSIKDRPAVRMIEQAEADGLLRPGATILEPTSGNTGISLAMAARLKGYRLICVMPENTSVERRQLLELYGAQIIFSAAEGGSNTAVATAKELAATNPSWVMLYQYGNPANTDSHYCGTGPELLADLPEITHFVAGLGTTGTLMGTGRFLREHVANVKIVAAEPRYGEGVYALRNMDEGFVPELYDPEILTARYSVGAVDAVRRTRELVHTEGIFAGISTGAVLHAALGVGAGALAAGERADIALVVADAGWKYLSTGAYAGSLDDAETALEGQLWA
The following text describes a protein:
Function:
Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein; Plays a key role in defense against host by cleaving histatin-5 (Hst 5), a peptide from human saliva that carries out fungicidal activity. The cleavage rate decreases in an order of SAP2 > SAP9 > SAP3 > SAP7 > SAP4 > SAP1 > SAP8. The first cleavage occurs between residues 'Lys-17' and 'His-18' of Hst 5, giving DSHAKRHHGYKRKFHEK and HHSHRGY peptides. Simultaneously, the DSHAKRHHGY and KRKFHEKHHSHRGY peptides are also formed.
Subcellular Localization:
Secreted.
Sequence:
MFLQNILSVLAFALLIDAAPVKRSTGFVTLDFNVKRSLVDPKDPTVEVKRSPLFLDIEPTEIPVDDTGRNDVGKRGPVAVKLDNEIITYSADITIGSNNQKLSVIVDTGSSDLWVPDSNAVCIPKWPGDRGDFCKNNGSYSPAASSTSKNLNTPFEIKYADGSVAQGNLYQDTVGIGGVSVRDQLFANVRSTSAHKGILGIGFQSNEATRTPYDNLPITLKKQGIISKNAYSLFLNSPEASSGQIIFGGIDKAKYSGSLVDLPITSDRTLSVGLRSVNVMGQNVNVNAGVLLDSGTTISYFTPNIARSIIYALGGQVHYDSSGNEAYVADCKTSGTVDFQFDRNLKISVPASEFLYQLYYTNGEPYPKCEIRVRESEDNILGDNFMRSAYIVYDLDDRKISMAQVKYTSQSNIVAIN
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAEDLAVGGGGAAVAPDPDGPDGVRMTWNSWPRSKVEASKCVVPVAASVAPIRSSPSLVVLPYSPLRCKPPCAAVLNPFARVDFAAKIWICPFCFSRNHFPPHYAGISEANVPGELYPQCTTVEYAPPPLDAAAPPLPPVFLFVLDTCLIEEELGFVKSAMRRAIGLLPDQALVGLITFGTQVHLHELGFADMSKIYVFRGTKEIPKEQILDQLGLSASGVRHGAVAGAPGYPKGPQANGFHPSTSVNRFLLPTSDCEYTLNSLLDELHMDQWPVEAGNRPLRCTGVALSVAAGLLGACSAGTGARIIALVGGPCTIGPGMIVSKDLSEPVRSHKDLDKDAAPHFHKAVKFYDNLAKQLVNQGHVLDLFASALDQVGVAEMKVAVERTGGLVVLAESFGHSVFKDSFKQIFEDGEQSLGLSFNGTLEINCSKDIKIQGIIGPCTSLEKKGAVCADTVVGQGNTTSWKMCGLDRSTCLTVFFDISPSERSNQPGIPNPQLYVQFLTNYQNPEGQMRLRVTTITRTWVDGSNTEELVEGFDQETAAVVLARYISLKMEMEEEFDATRWLDRSLIRLCSRFGNYRKDDPSSFTLHPNFSILPQFIFNLRRSQFVQVFNNSPDETAYFRMLLNRESVSNSVVMIQPSLISYSFNSPPTPALLDVASISADRILLLDSYFSIVIFHGMTIAQWRNMGYQNQPEHQAFALLLQAPNDDAQMIIRERFPVPRLVICDQHGSQARFLLAKLNPSATYNSAQEVVPGSDVIFTDDVSLRVFCEHLQRLAVQS
The following text describes a protein:
Function:
Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Subcellular Localization:
Sarcoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MTEGHEVRSSVTTTMVIDSKNGEAGTPSGRMSKKTFTDDLHSTFSSPLAWILVLALLITWTCVFVIMFDLMDYKTISDHPPSGIRKVWKDPGRRGGINKISSDPMKVVNDAVEESSNVFTAIINFGASLIAPEEEGTIYAVRKKGEFLPPRSKVLEMQIQKEVTDVEEEEEEEEDEEELVKEEGEEDDDDEYEEYDEEEFAEEYEDYYGEDAEAEEEEEEEGEEDEEEEEWEGEEEELEEEEVDEDEDGAEDEGEEVVDEDEEGIEEEEEGEEEKVVDGDEEEEEEGEVEEVGEEDEEGAEEEEEGEAEEVVEEDEEGTEEEEEGEEEEVVDGDEGDEEEEEEGEVEEDGEEDEEGAEEEEEGEVEEGENMETEEDGDEEEEQGGVSEEDIVEEGEEEELEKMEEEDKEAKEDKDEKLQEDITEDEDDKDIEEDKAVEPPADEDMGEVEAEEADEDDEAPATADQVEDKDEAEPEPKPEDKDEDDLEEEAADEDENKDEKMSEAEEEDEAVATDEPVEEEEEESSEEVSPEPVFTSEDEEFALSMDSEAEALDDLKESDEDLTLSDEGDTTGDEEVFDSSDVSESLLLSSDEEEGKDESSDEDVPTSDSDDLPADTDDDLSLDLPPLVIDSEDEEEDDLKPLGEEDLPPLPPIKNDDERDEEDLKFTDDDLDQSEEDDSIATSEHFADDEEEEEDIEDEDFDEDVLVTVDEKNKDEPEDDDDHDEEESIIPLSSASDSGVLGDEDEKDDISIKLDEGFSGDLSTSDDYESQDENEEEEEDEEFKESYSDEEELSEDEEEDDNILLAAAAAAALPHQEEAPKTDEAEGGEELTQDEDEDELVEAETDSSQLDEEDEEEEVGETKADSKVHEQEDKEEEDDEDNEEERATVNVMKPLPEVEDEAAEPEPGECPCLHSAKSKEPPSGKSKGAPRRVSALRRRKGLESVSPVEKLQKQGLPRIADLDSKPKRVRLAPLLKAKLKQKSKAAKKEKETKKQEHLTESAPEVGPCRPAPVYCPSPAGWYVHHIVTDNPYPPPTVSAPSAPVVTVHPGGPPHPPVYHQQSPPPLMQPLYAPYQPYPPLYQPVAPPPQEVVDPVQPIQPEEPEAPEHKEAVQPEVQTTAPAPPDVPAAPPAPPQEPETVVEEDKSAPTKKATKKKVKAADSVKELTAKKEKPKSKAVTKKGPAAATQKRKSTSAKTAAVKRKVKASAEKKDPDPKVRPLRYRYKRLQDEKRANVTSSIRKESPVRSSKSGKPRLRLQPQKKTAKAERKPVKQAEDKEKHPPQIKDVKAEDNVTEKKKSGQKFFQCIYVPGKSVQYPLRPFTPAMSPAMLSPAIRSMLEQQRAARAAGQ
The following text describes a protein:
Function:
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
MEGGSILETIGHEIIGVMSPVSICMLLVVLLVYSVYNPSSAAASATTIRTAANLVYLESPSDSTAQKLEGAVLNAVVFVVFLTLVTFLLLLLYYYRFNNFLLYYTRFSVFTIFSTMGSSILISIVQRFNIPIDAVTFYVLLFNFTVLGTISVFSNGIPIIVKQSNMVVLGIIVAAWFTRLPEWTTWVVLVALALYDLAAVLAPGGPLKLLVELASTRDEELPALIYESRPNIGRNSAARDSSLGLFVAAGLGMSTDNNNNNNSNSGSVELQDMLRNGDSNNGNEARGGGDSVISVEEDGGETSPLMQRRLNDTTDYNNNSDNNGRVLRGDQTEEVEMEEVNSRGIKLGMGDFIFYSVLVGRAAMYDLMTVYACYLAIISGLGCTLILLAVCRHALPALPISITLGVVFYFLTRLLMEPFVVGCSTNLMMF
The following text describes a protein:
Function:
Adenine glycosylase active on G-A mispairs; Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MKRLRSQVKSCLKTETVEIENSETLRNHHHALLEEEIRNLREKLINWYDINKRDLQWRDLAKHIDPNIRGYSVLVSEIMLQQTQVATVKSYYSKWIEKWPDLTALSKATLEEVNTLWSGLGYYSRGKRLHEAACKIVHEMDGTMPQKAEQLQKQLPGVGPYTAAAIGSIAFNERVGLVDGNVIRVITRLCSIGADTSKKSVVDVIWKLSNEMVDPERPGDFNQGMMELGATVCTPKSPLCQSCPISLMCRAYKRSNPKEAAGPADIEDVPDCLLCLPIDQPWTVKDGVTNYPRKAKKTAAKIARNIVLIVERPTNESDSNEYLLWQRPVNGLLANLWEFPSFPSHQWSDDLDESSELTAALDQSKGLLTGRTIERCQYVADVFHQFSHISQTYGLYRVAVRACENAKDNVVSLPDHYQGFRWLNARQIAGAAISTAMKKVFRAFTQNVDGSGSSSSLKRKTKSKETGTVSKKQMTLQSYFKNSQTE
The following text describes a protein:
Function:
May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis (By similarity).
Subcellular Localization:
Endosome membrane; Multi-pass membrane protein.
Sequence:
MSEVRLPPLRALDDFVLGSARLVAPDPCDPQRWCHRVINNLLYYQTNYLICFGLGLALAGYVRPLHTLLSALVVAVALGMLVCAAENRAAVRRCRRSHPAACLAAVLAVGFLVLWAAGGAGTFLLSIAGPVLLILVHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS
The following text describes a protein:
Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions.
Sequence:
MNYIARCTWKGMNGDPFYEAYHDTEWGVPEWDSRALWEKLVLDGFQAGLSWITILRKREAFRAAFANFDPEKVARFDETDRARLMADAGIIRSNGKIDATIAGARLYLDMRERGEDFGQFLWDMVGGAPIQNQWEAGQVPAQTPLAVEMSKALKAKGFKFCGPVIVYAFMQATGLVNDHLVSCFRHEDCKALGRH
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MALMSKMAPAAACACRSAFLKPSTSVIPAIRSSHAAVFRKRPGQLIVNRIKDVCHFYFIGIGFLPVLFCLAYNHIVYGTCELKDYPTEGPAPHHWQFERTPIRQWWAKWFGVSDVEHHERNLAYYEKQGILARWRQIEQRVKHLEGERWDYKGWSYQPVSSTWVDYGRWHALRMRDQYEQHGHYAQ
The following text describes a protein:
Function:
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication (By similarity). Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MTAIVGFDQLSKALIDAGTNLLSPPSSTDDLLTLLDETESLLKNVEQDQPLSMQSALIPSRNALVSVDLLSHPDSDVRVSVVSCLTEIVRITAPETPYSDDLMKEIFRLTIEAFEKLADASSRSYKKAEFVLDNVAKVKSCLVMLDLECYDLILQMFRNFFKFIRSDHPQLVFSSMELIMIAIIDETEQVSTDLLDSLLATVKKENQNVSPMSWSLAEKVLSRCARKLKPYIIEALKSRGTSLDMYSPVVSSICQSVFNTPKVHSPVNTKEHEEKLDLGHSRKENLSKSSSKRPARHETRGINEKEKVRNGNKSSLLKQSLKQVRSESTDAEITGKRGRKPNSLMNPEDYDISWLSGKRDPLKTSSNKKIQKKGSGGVSSLGKVPAKKTPLPKENSPATSSRSLTGSLKRSRVKMDESDYDSDSLSSPRLKKLASCFRDEEPNQEDDRKIGNSSKQTRSKNGLEKSQKTAKKKPVVEAKIVNSSGKRLSARSVAKRRNLERAPLDTLVPQSSKRKKMVSQVAARQLANESEEETPKSHPTRRRTVRKEVESDGFGEDLVGKRVNIWWPLDKTFYEGVIDSYCTRKKMHRVIYSDGDSEELNLTEERWELLEDDTSADEDKEIDLPESIPLSDIMQRQKVKKSKNVAVSVEPTSSSGVRSSSRTLMKKDCGKRLNKQVEKTREGKNLRSLKELNAETDRTAEEQEVSLEAESDDRSEEQEYEDDCSDKKEQSQDKGVEAETKEEEKQYPNSEGESEGEDSESEEEPKWRETDDMEDDEEEEEEEIDHMEDEAEEEKEEVDDKEASANMSEIEKEEEEEEEDEEKRKS
The following text describes a protein:
Function:
Phosphodiesterase specific for extracellular cAMP. Involved in the degradation of extracellular cAMP specifically during multicellular development.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFNNNNNDKINNTMMSNNPSGQIINLESIDCNSNLSNTTSIKDSNNNNNNNNNNNNNINNNINKINPNIDRKVLDDFNSKSIKIIDNKLNKKNSKKNLYSKEVDDDINKINLNKKIIPNETNSNNSNNNNNNSNNNNNNNNNNNNFNYNNNINSNNNIINNNNNINNNSNNNNNNNNNNSISLYVDTQEKSKKKVNAESLRGPIIFQNFILYTFFLIVIGTAEGTSWAPEIRVANFVPYCVMCVVLLEFNRLHKKPLLRIIFPLYTSNIPFAYMCIFSREARKYVLISLLFFASCLCIFLQSGIPDLRKHIVIFCIIFMINYGCCILFMDWFYIDTTGTKPYRGRILATKIHWGEEATILVSMALLGCIFIVLEKFIKSYARCVAEQHYQIQCLQKEKEKLQTEINISLKKLDLDTPIEKIMDILRSMINTSESENDKKQLIKVIAVLGSNKLYDPDFKFETCTDDAEVYSWLQSMLNREVGYSNVNNNNNMMMIENNNNNTIINNNLIEPTSPNFSKKLTSSDLIPRIRSMPEITDQGIQELIINNFLEWDFPVFQLSEITDGNPLFYMSYFLFSRHKFFEKFKIGIDCFKNFMRKIESGYDSTNPYHNSIHATDVLHNLNYFIEKSFGKFLTDIELFSMILAAIIHDFKHPGVNNHFQINSKSRLALKYNDKSILENYHLHQAFIIMNEPESGILLKLSDSVRKEIRETIIALVLSTDMAKHFNLVGRFKSMANSFPTTTNTQQPSSSSSSSSSTTIPTSTITPTPNSTTSTTTTTTTTTTTTNNNNNNNSNNNSLNNIINNCSSSNGSMGASGADNSNSNNTNNSNSNNQNQCGSSIFLNSNKKDRLLLMKISIKCADISNPSKPWNLYTNWSNRVTSEFYKQGDKEKESNMDVSAFMDRNKPATTKCQINFINIFVAPIYEIWSHHFPQFKLCYQNILSNLSRLEIEQQQQLQLQQQQQQQLQQQQQQQQQIHQQQQQQLHHHQQQQQFQHQQHQQQLQHQHQQQLNNQNQNQNQSNSNNSNSFGLTQSNYLIVV