lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasmic vesicle membrane.
Sequence:
MGCRDTAALNDLELMLLDETADPKALPLSLLKDITNDFSNDRQIGRGGFALVYQGVLESGTVAVKRLSDMCMDEKKFHGEVQCLMKARHKNIVRFLGYCADTQGNMLSYNGKLVMADVRQRLLCFEYMSKGSLRDYISDESCGLEWRKRYQIIIGICQGLNYLHENRIVHLDLKPENVLLDDNMVPKITDFGLSRYFEERQTSQSITSNISGTLGYIAPELYDGEKITIQSDIYSLGIIIIEILTGRKGCPDVEVVLERWCERLGKSLEDTHVEQVRVCTEIGIECSDFNPAKRPVSTHKIIERLKETETTDEVSSVLSSTVPTKLFVHPHLLCFPCVPNKLIPSSLNLRNFTDEHFAFRLVESYAEETERRFAKLPLYGVVSPRSTHTLSLTLQERDEKSIHLVLESSTFKDAHMPMYCSEFRGDKFLEETKEKGNMVQQVIVKAVATTAQREITSELIPNKTKILFKKSPFTSLDCQDVNLTKQWIITGHTRGYVCIWDGQTQRKVDSFKVSTDKVVLVKFIVRKQWFVAGAEDGFIHIYNYETKRQQVPSFTAHAGKMTSLAVHPSKPYLMSWSSDEMKLWDWDKAWECTQTFKCKHLGYICQVMFDPKNTNSFVTASANHMIDVWDFDSPQCKYTLSGHWDRVNCLDFFTHDNQQYLITGSSDCSAKIWDMHSNMCTHTLHASMSPVMSVMFHPNLQVLITGLEDGTVYLWSSTNFRLERIINPPVIEPPAWGFGWIYNIFSSPVSEHVWGLACSMKSKGFVFGRGETVAMVDVGNVNNQEESSHHSVPQIRADKSTQLIDNSGLLEVHPSDLRFPLQPHKSTTCSLDLTNHTYERVAFRLVQKNKSHSFGEEEDSLLSNVPIYGFIASRSTYTLVVTTKEWPDQGDDTSLDLLLQSSISGDKFIVPFENETECVDLFEELKEMGNVVHELTLKAVFYAQEEVTREIRSATKKVDALGFGNRLVCLDAHPTETWILTCKFFGDVHMWDLVSQEKKALYSFHVYQNGTRGLSATVRFLKFIARKQWFLAGADDGFIHVCTYGTEIVQQITSFRAGSSSVTAMTIHPTQPYVLSSAYESPIRLWNWEEGWQCTRTFDDERSGTVRQITFNPKDANCFASASEDQTVKVWNLDSPKSSYTLFGHLAQVNCLDFFAHADQQYLISGSDDLTARIWDLENRVCVYTIRALMAPVLSVLCLLPDHPYLTIGLKDGTLHLFSSANFRLVRIIDLGCSKVRSVNLMGSVRVVIEQEGAVSIMDIDPEQQGGIISEVGANMVDAVRLDVASEAQLDIFQEHKEDLSSTTRHLPRTQRGFVRCSVRDRKYEFHTGVRNAMGYNNRLVLTEFRPQRKEIRK
The following text describes a protein:
Function:
Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein. Secreted.
Sequence:
MRLRNGTVATLLAFITSFLTLSWYTTWQNGKEKLIAYQREFLALKERLRIAEHRISQRSSELNAIVQQFRRVGAETNGSKDAVNKFSDNTLKLLKELTSKKSLQVPSFYYHLPHLLQNEESLQPAVQIGSGRKGVSIVMGIPTVKREVKSYLIETLHSLIDNLYPEEKLDCVIVVFIGETDTDYVHSVVANLEKEFSKEISSGLVEVISPPESYYPDLTNLKETFGDSKERVRWRTKQNLDYCFLMMYAQEKGVYYLQLEDDIIVKQNYFNTIKNFALQLSSEEWMILEFSQLGFIGKMFQAPDLTLIVEFIFMFYKEKPIDWLLDHILWVKVCNPEKDAKHCDRQKANLRIRFRPSLFQHVGLHSSLTGKIQKLTDKDYMKPLLLKIHVNPPAEVSTSLKVYQGHTLEKTYMGEDFFWAVTPVAGDYILFKFDKPVNVESYLFHSGNQEHPGDILLNTTVEVLPFKSEGLEISKETKDKRLEDGYFRIGNTYFKPVKYPLLFWTYA
The following text describes a protein:
Function:
Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1.
Subcellular Localization:
Cell junction, focal adhesion.
Sequence:
MTLNNCASMKLEVHFQSKQNEDSEEEEQCTISSHWAFQQESKCWSPMGSSDLLAPPSPGLPATSSCESVLTELSATSLPVITVSLPPEPADLPLPGRAPSSSDRPLLSPTQGQEGPQDKAKKRHRNRSFLKHLESLRRKEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGFYRAKNWAATSAGGSGANTRKAWEAWPVASFRHPQWTHRGDCLVHVPGDHKPGTFPRSLSIESLCPEDGHRLADWQPGRRWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDEDDEESGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEATSSVEIATVEVKCQAEALSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQDSEQEAHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAAGPLAGLQASMPRERRDSGVGASLTRPCRKLRWHSFQNSHRPSLNSESLEINRQFAGQINLLHKGSLLRLTAFMEKYTVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKLTTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAEENQMTAGNLAVCLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKLFQVPQDMVLQLCSSYSAAELSPPGPALAELRQAQAAGVSLSLYMEENIQDLLRDAAERFKGWMSVPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQVLEALMPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESGVRALMLTSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQAAGPETKL
The following text describes a protein:
Function:
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.
Sequence:
MPRCPAGAMDEGPVDLRTRPKAAGLPGAALPLRKRPLRAPSPEPAAPRGAAGLVVPLDPLRGGCDLPAVPGPPHGLARPEALYYPGALLPLYPTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPNFFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS
The following text describes a protein:
Function:
Probably involved in membrane trafficking.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein.
Sequence:
MAVAVLWSQGGEVEQESLFLAVAYLVLGVPAAYSSWHRTLSLAFQEKKRLTFKWFLVFYLFHLAFCLFASISPIEGRSLTGVLSAMAVSSDHGFARVLYFVGFVLFSYEYALSFWVMLSVYMYYRHGGVSLGDDLTSMEP
The following text describes a protein:
Function:
Serine protease inhibitor. Strongly inhibits trypsin (Ki = 7.1 nM) and almost completely inhibits elastase. Also inhibits chymotrypsin (Ki = 19 nM). Does not inhibit bacterial subtilisin.
Sequence:
QTWPPVEDRPHCKRCVACTLMWPPEANRCVCGDLVPKCHKGCSQCEKADTRSGRPLYKCLSFEYYNCAAD
The following text describes a protein:
Function:
Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVTSYPLPEGFSEFDVFSLGSCLLVEGLLGFFLNAVTVIAFLKIRELRTPSNFLVFSLAMADMGISTNATVAAFSSFLRYWPYGSDGCQTHGFQGFMTALASIHFIAAIAWDRYHQYCTRTKLQWSSAITLVLFTWLFTAFWAAMPLFGWGEYDYEPLRTCCTLDYSKGDRNYVSYLIPMSIFNMGIQVFVVLSSYQSIDKKFKKTGQAKFNCGTPLKTMLFCWGPYGILAFYAAVENATLVSPKLRMIAPILAKTSPTFNVFVYALGNENYRGGIWQLLTGQKIESPAIENKSK
The following text describes a protein:
Function:
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MTEYKLVIVGGGGVGKSALTIQLIQNHFIDEYDPTIEDSYRKQVTIDEETCLLDILDTAGQEEYSAMRDQYMRTGQGFLCVYSITSRSSFDEIASFREQILRVKDKDRVPMIVVGNKCDLESDRQVTTGEGQDLAKSFGSPFLETSAKIRVNVEEAFYSLVREIRKDLKGDSKPEKGKKKRPLKACTLL
The following text describes a protein:
Function:
Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
Sequence:
MYSEWRSLHLVIQSDQGHTSVLHSYPESVGREVANAVVRPLGQALGTSSVAGSESLLKTDKEVKWTMEVICYGLTLPLDGETVKYCVDVYTDWIMALVLPKDSIPLPIIKEPNLYVQSILKHLQNLFVPRQEQGSSQIRLCLQVLRAIQKLARESSIMARETWEVLLLFLLQINDILLAPPTVQGGIAENLAEKLIGVLFEVWLLACTRCFPTPPYWKTAKEMVANWRHHPAVVEQWSKVICALTSRLLRFTYGPSFPPFKVPDEDANLIPPEMDNECIAQTWFRFLHMLSNPVDLSNPAVISSTPKFQEQFLNVSGMPQELSQYPCLKHLPQIFFRAMRGISCLVDAFLGISRPRSDSAPPTPVNRLSMPQSAAVNTTPPHNRRHRAVTVNKATMKTSTVTTAHTSKVQHQASSTSPLSSPNQTSSEPRPLPAPRRPKVNSILNLFGSWLFDAAFVHCKLHNGINRDNSMTASFIQILLSYKSSIATQASMEFRRKGSQMSTDTMVSNPVFDASEFPDNYEAGRAEACGTLCRIFCSKKTGEEILPAYLSSVILNSPPLFCCDLKGIDVVVPYFISALETILPDRELSKFKSYVNPTELRRSSINILLSLLPLPHHFGTVRSEVVLEGKFSNDDSSSYDKPITFLSLKLRLVNILIGALQTETDPNNTQMILGAMLNIVQDSALLEAIGCQMEMGGGENNLKSHSRTNSGISSASGGSTEPTTPDSERPAQALLRDYGSTDSAAGLLIRSIHLVTQRLNSQWRQDMSISLAALELLSGLAKVKVMVDSGDRKRAISSVCSYIVYQCSRPAPLHSRDLHSMIVAAFQCLCVWLTEHPDMLDEKDCLKEVLEIVELGISGSKSKNSEQEVKYKGDKEPNPASMRVKDAAEATLTCIMQLLGAFPSPSGPASPCSLVNETTLIKYSRLPTINKHSFRYFVLDNSVILAMLEQPLGNEQNDFFPSVTVLVRGMSGRLAWAQQLCLLPRGAKANQKLFVPEPRPVPKNDVGFKYSVKHRPFPEEVDKIPFVKADLSIPDLHEIVTEELEERHEKLRSGMAQQIAYEMHLEQQSEGELQKRSFPDPVTDCKPPPPAQEFQTARLFLSHFGFLSLEALKEPANSRLPPHLIALDSTIPGFFDDIGYLDLLPCRPFDTVFIFYMKPGQKTNQEILKNVESSRNVQPHFLEFLLSLGWSVDVGKHPGWTGHVSTSWSINSCDDGEGSEPDEITSSEDVGASIFNGQKKVLYYADALTEIAFVVPSPVESLTDSLESNISDQDSDSNMDLMPGILKQPPLTLELVPNHTDSLNSSQRLSPSSRMKKLPQGRPVPPLGPETRVSVVWVERYDDIENFPLSDLMTEISTGVETTANSSTSLRSTTLEKEVPVIFIHPLNTGLFRIKIQGATGKFNMVIPLVDGMIVSRRALGFLVRQTVINICRRKRLESDSYSPPHVRRKQKITDIVNKYRNKQLEPEFYTALFQEVGLKNCSS
The following text describes a protein:
Function:
May act as a translational repressor which regulates translation of specific mRNAs.
Subcellular Localization:
Cytoplasm, perinuclear region. Cytoplasm.
Domain:
The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
Sequence:
MDFLNHNYLSARASYDYTFNFWNDYLGLSTLVTKNSKHSVPQNPNSITESLKATLGLDDSPPCPCVMGEGDSGGHLDSCCCPPPASISILDLKERFSILSPFQNQNQGSLLSSSQEREIGIGGGFAGFDLFGVERKMRKPAARNKQEPKICVFCRNNGAPEEVYGSHVLKTPDGRVVCPILRAYTCPLCSANGDNAHTIKYCPLSKDQPAQRVLKGGRAVGGKRVKIF
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as CGAS. Acts as an inhibitor of cGAS/STING signaling by catalyzing lactylation of CGAS, preventing the formation of liquid-like droplets in which CGAS is activated.
Subcellular Localization:
Mitochondrion.
Domain:
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Sequence:
MAAAGPLRLPLLAVRPPWPRCPRRGAARPPAGQIRAAFLRFFEEKHGHRCLPSAPVRPRGDPTLLFVNSGMNQFKPVFLGTAHPRSELAQQRRVVNSQKCVRAGGKHNDLEDVGRDTYHHTFFEMLGNWSFGDYFKEEACSMAWELLTEVYKIPKDRLYVTYFGGDSSLGLNADEECRDVWLSLGVPANHVLPFPMKDNFWEMGDTGPCGPCTEIHYDHVGGGRNASALVNQGSPDVVEIWNLVFMQYSREVDGNLLPLPQHHVDTGMGLERLVTVLQNKRSNYDTDLFTPILDAIHKGCGGPRYQGLVGNADVGHVDMAYRVVADHVRTLCVCITDGIYPGLSGAELVLRRILRRAVRFCAEVLHAPRGLLASLVPAVVEVLGDAYPELKKNADQVMDIINENEVAFLSSLERGRRIIERTVQQMKPSADFPAEVAWSLYGNLGFPLDLIDLMLEEKGIRLDSAAFNELVLEDAKRKAHGPQEGRQLEGTVVHLDVHSMAQLQRDNIPATDDSPKYSYKLGQHGQYEFSPCQATILMLYRDQSLQKEVGAGQHCGVILDRTNFYAEQGGQASDRGYLIRLGQQDILFPVESVRLCGGYVIHEVTAVETLRAGDQVQLFVDEVQRLACMTNHTATHLLNFALRHVLGDSTEQRGSHVTAEQLRFDFNIKGPVTVEQLQQVEQVVQDVIKRNEAVYMAEVPLALARRVQGLRALDEGYPDPVRIVSLGVPVETVLTSNSQAAMQTSVELCCGTHLLQTGAMEDLAIVSERQLVKGISRVIAVTGRQAKQAREVGQCLAMEVDSVSIRMKQKRITSVLEMQNLSKEVGQLTKVVASTAMPQWQRRELQSILKSLQRTANTTIKKLEVQQAEEKAQRLLAKHCNQPVIIDTVPADSLSILMKVVNQLCDKSPGTSVLLLSPQDSGEVLCACQVSKNCLPMFSAADWAVAVCTQMEGKAGGSPVVAKGSGNAKGMQGALTTALEFAQSKL
The following text describes a protein:
Function:
Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAPFQSNKDLISTGIKEFNVLLDQQVFDDPLISEEDMVIVVHDWVNLYTNYYKKLVHGEQEEQDRAMTEFQQELSTLGSQFLAKYRTFLKSKEPPSNTLPSS
The following text describes a protein:
Function:
Cation/chloride cotransporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGMIEPNRSVLLNGSMNGSENIKDLFHEDAQVSQLQSRPWWKIQLFVWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGIVLVSFVILVALVTVLSGIGVCERCSIGSGGVYSMVSTVLGGKVGGTIGVLYIFGQCVAGAMYITGFAESISDLLNLENMWVVRGISLAVLVGLLGINLAGVKWIIRLQLLLFLLLAVSTLDFVIGSFTHLDPENGFVGYSEELLRNNTFPDYTPGESFFTVFGVFFPAATGVMVGFNMSGDLQRPSINIPLGSLAAIGTSWFLYVVFVFLLGAICTREFLRYEFMIAEKVSLVGGLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALSFLGRGKGPNKTPVAAIFITGLLTMAFVFIGQVNVLAPIVTINFMLTYSAVDYSYFSVTMSYKMQHSPKKNGRPNSRVMSSTQPLILNKSTSYGSNGTLLEFTKDMNQLFKPNHTEAPESTSSQEKDPKMFKFSKPRKPAKQTLQDSFQLDLHQGPEHGLESRLLVTDLAENESQNSKAEITEDKNQGVDPTESDEPDSEEDVDIQQPTEEQKGDSTVAQKVPEFEIQELSTSFYAKFCNHWVAFLGAILSIVIMFVIQWIYALVNLGVAIILYLYIGRVNPGLNPGAAANFSFFAWIRQGARTLCRKPHPKEQFVVTPSLLSVGMETTQLTEENEDFASRGRYHHSSIITQGQFIDRYN
The following text describes a protein:
Function:
Plays a role in the resistance against the toxic effects of L-methionine sulfoximine (MSX), a rare amino acid, which inhibits glutamine synthetase (GlnA). Catalyzes the acetylation of L-methionine sulfoximine (MSX).
Sequence:
MSASIRDAGVADLPGILAIYNDAVGNTTAIWNETPVDLANRQAWFDTRARQGYPILVASDAAGEVLGYASYGDWRPFEGFRGTVEHSVYVRDDQRGKGLGVQLLQALIERARAQGLHVMVAAIESGNAASIGLHRRLGFEISGQMPQVGQKFGRWLDLTFMQLNLDPTRSAP
The following text describes a protein:
Function:
Serine protease with a broad substrate specificity.
Domain:
The C-terminal calcium-binding beta-jelly roll domain (445-562) of the mature domain is not required for folding or activity, but it is required for the hyperstabilization of the protein and possibly for its adaptation to high-temperature environment.
Sequence:
MKKFGAVVLALFLVGLMAGSVLAAPQKPAVRNVSQQKNYGLLTPGLFKKVQRMSWDQEVSTIIMFDNQADKEKAVEILDFLGAKIKYNYHIIPALAVKIKVKDLLIIAGLMDTGYFGNAQLSGVQFIQEDYVVKVAVETEGLDESAAQVMATNMWNLGYDGSGITIGIIDTGIDASHPDLQGKVIGWVDFVNGKTTPYDDNGHGTHVASIAAGTGAASNGKYKGMAPGAKLVGIKVLNGQGSGSISDIINGVDWAVQNKDKYGIKVINLSLGSSQSSDGTDSLSQAVNNAWDAGLVVVVAAGNSGPNKYTVGSPAAASKVITVGAVDKYDVITDFSSRGPTADNRLKPEVVAPGNWIIAARASGTSMGQPINDYYTAAPGTSMATPHVAGIAALLLQAHPSWTPDKVKTALIETADIVKPDEIADIAYGAGRVNAYKAAYYDNYAKLTFTGYVSNKGSQSHQFTISGAGFVTATLYWDNSGSDLDLYLYDPNGNQVDYSYTAYYGFEKVGYYNPTAGTWTIKVVSYSGSANYQVDVVSDGSLGQPSGGGSEPSPSPSPEPTVDEKTFTGTVHDYYDKSDTFTMTVNSGATKITGDLYFDTSYHDLDLYLYDPNQNLVDRSESSNSYEHVEYNNPAPGTWYFLVYAYDTYGYADYQLDAKVYYG
The following text describes a protein:
Function:
Cell surface beta-glucosidase involved in cell wall biosynthesis and septation, and thus required for normal growth and correct hyphal morphogenesis. Has hydrolytic activity on linear (1->3)-beta-D-glucans such as laminaribiose and other laminarioligosaccharides. Also has a minor transferase activity.
Subcellular Localization:
Secreted, cell wall. Secreted.
Sequence:
MKFNTVALTLATAGSLVTAQHHHQHRHHQHKREDVVESSATVVQYELDGKPISLKQVCAGLADNTLKFANNDHPTGICDNLSSAAAPASTPEVTSAFAPAQFIELSSVVTSATPTSASSSETVQTPAASSSSASSSSTATGLDADFPDGELDCSTFPSEYGAIPLDYLKLGGWSGIQYVSYAGNFINDIVTAVAGDTCKDGAMCSYACPPGYQKSQWPSTQGATGQSVGGIECRNGKLHLTNPSLSKKLCIPGVGGVHVQNTLGETVAVCRTDYPGTESETIPIGLGGNDLQPLTCPDGETYYKWQGKTTSAQYYVNPKGVTPEKGCQWGDGTQPIGNWAPVNLGVGLNKGKWLSIFQNSPTTSEKLDFNIKIKGDNLSGSCKYENGVFYSETGSSSSGCTVQVMSGDATFVFY
The following text describes a protein:
Function:
Putative gamma-glutamylcyclotransferase.
Sequence:
MEYVFVYGSLRKGFWNHEPYLKNSKFIGKGKTKEKYAMYVNIIPYVVENEKISHIVGEVYEVDEKTLKRIDCLEGHPDYYRRKKVSIILDSGKEIEAWLYFYPESCGILVESGDYKDYRG
The following text describes a protein:
Function:
Part of a potassium transport system.
Sequence:
MYIIVVGAGDIGSQVIQLLTKSANEIVVIETDPDVADQVSRDYDCLVLNADATAKDTLVDAGSEKADAIITTTDRDPTNIMVMLLADELDIESKVSVVQDPDNMELFRRIGVNVLENPQRLIGEYLVRAVQRPSIKDFMTLGGEAEVFEITVTEDAPLAEQTLQDADTNGLLGDDVLVVAIERGDDVITPRGETTIHAGDLITAFSKHGVTSSVMQTFTGSE
The following text describes a protein:
Function:
Essential for differentiation and fruit morphogenesis.
Sequence:
MSNSNNNSSSGNHNSTTINNPKVNVYSNIPNSTTYTYGSGGGGTLSGNNTNNNNTNNNNNNNNNSSGDNKNHSPVTSATDRLTKMDIEEKWDNKNYEKDEREKSPLFHILASNLNSFGNFKVPSTFSLTPPEPNKQQQPQQQPQQQQPQQQQPQQQQPQQQQQQQPQQQQQPQQQLQQNNQQQQQQLQQQQLQQQLQQQQQQQQQQQQQQQQKQQKQQQQQQQHLHQDGIVNTPSTTQTSTTTTTTTTTTNPHTSGLSLQHAHSSYTPSNVLHSPTHFQSSLPTRLDTNPITTPIRQQQQSQQQLQQQQLQQIPPPTVNSFFLPPPVNARERLKEFKQIRVIGTGTFGKVYLIQNTKDGCYYAMKCLNKAYVVQLKQVEHLNSEKSILSSIHHPFIVNLYQAFQDEKKLYLLFEYVAGGEVFTHLRKSMKFSNSTAKFYAAEIVLALEFLHKQNIVYRDLKPENLLIDNQGHIKITDFGFAKRVEDRTFTLCGTPEYLAPEIIQSKGHGKAVDWWALGILIFEMLAGYPPFYDDDTFAIYNKILAGRITFPLGFDVDAKDLIKRLLTADRTRRLGALKDGALDVKNHRWFSDINWERLYQRRDNGPFIPKIQHQGDSSNFEMYDEEEMVEEPPSSNYVDPYAHLFKDF
The following text describes a protein:
Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
Miscellaneous:
MISCELLANEOUS: The guinea pig differs from other rodents by an absence of beta-3 adrenergic effects and by low expression in brown and white adipose tissues. It is closer to human or primate than rodent beta-3.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAPWPHENSSAAPWPDTPTLAPNTANTSGLPGVPWAAALAGALLALATVGGNLLVIVAIACTPRLQTMTNVFVTSLAAADLVVGLLVVPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYRAVVTKRRARAAVALVWAVAAAVSFAPIMSQWWRAGADAEAQLCHGNPRCCAFVSNVPYALLSSSVSFYLPLLVMLFVYARVFLVAQRQLRLLREEVGRFPPQGSPRIRSRSASPAQGGGMRTAPAGEAPCGPRPARLLPLRERRALRTLGLIVGTFALCWLPFFLANVLRALGGPSLVPNSVLLPLNWLGYVNSAFNPLIYCRSPDFR
The following text describes a protein:
Function:
Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle. May be a regulator of axial polarization in the retina.
Subcellular Localization:
Nucleus.
Sequence:
MGDGGAERDRGPARRESRGGRGGDSGGAEDSSADAGGRSARDIAGTSASSPAGSKESSADSDGQPGLGEADHCRRILVRDAKGTIREIVLPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQSRDLEKRASSSASEAFATSNILRLLEQGRLLSVPRAPSLLALTPGLPGLPAGHRSTSLGGPRNSSPRLNPLTSAPASPTLPPPPPALCFSTAPLLDLPAGYELGSSAFEPYSRPERGVGSPVGGKKTNA
The following text describes a protein:
Function:
3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MQRRFLSSISATAGNTKTLNQGRWSVKQVKKSNFHVTLDEIRTSIDSSDFIALSLQNTGSYAAAWHRVSAIDTPQTSYLKAKYAAERYQILQFALCPFSLQGSKLTVHPYNFHLFPRDELKCGMPSYSFSCQASRLTAMAREGFDFNICIYEGISYLSRAQESASKFLSENPILADSVTVSSSPATVADTVFVGRIRSRVKNWRQSCIDSGSKTGDDDLVSSLRRLVLGSEQYGSRLCLTIDVCSERQVQLILEMLTEFSDDVVPLLVASKSRGTQAVRTVFMSSKEDKDLFKRELKDLEKEENRRVRGFREVVDFISSSQKPVVSQNYLSDFTSIHAKFLGPLPSNVDDFSSSLSSAFPNVVDLSQFMKEISPLSNISNLPAAMSSLNRFFAPVDVEVANQGCPVKLDEGHQSHGQNAVMISQLFAKLCTIQKSDLSTIQSNEDFQALASDEHANSVTSCSKNAGDENVKVWSKNSRRVSSENLVFIWGLGKKMTAAKLKNVLQKSHPVFAREFDVKYIDRSSAILVFWESGPSETFLSAVNNEEQLDGSLREMVAEGLRGAGYETYKRACRLGFWEADLAESLDKALESSDTDPDSDTKPSEIDWSNELAINFDEL
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis. May be involved in the synthesis of short and medium chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain.
Sequence:
MQSAGTGIRLFRSSWKLAEKCRNSTPALSIIDHGETVKKNPNILGAFGMRSFSQVAYSPATFIDNEEVTRRVMELLKSKPFIDPSKVSPTASFEDLELDILDSAELMMAVEEEFAVDIPNEDSDKMATTAQVIDYIAAHPQAK
The following text describes a protein:
Function:
mRNA-binding protein which interacts with a range of target mRNAs and may promote extracellular matrix production. May function as a component of lumicrine signaling and may play a crucial role in epididymal-mediated sperm maturation and male fertility.
Subcellular Localization:
Secreted. Cytoplasm, perinuclear region. Note=Detected in the perinuclear region of fibroblasts.
Sequence:
MALPSAWSVMRVVIPFISVLGLLGVRLVGASQDSGSVIPAESRPCVDCHAFEFMQRALQDLKKMAYNLDTRTETLLLRAEKRGLCDCFPAMH
The following text describes a protein:
Function:
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.
Subcellular Localization:
Cytoplasm.
Sequence:
MADRNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPTENTTGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA
The following text describes a protein:
Function:
Phosphorylates translation factor eIF2alpha in salivary gland sporozoites during dormancy, which leads to an inhibition of protein translation and accumulation of stalled mRNAs into granules.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLNMVDQKKGINNGSSTGVINNINGKIKNEFIFMYLIAAGGFSCVYKIKKKKSNKFYALKKIKFSANESNYEKKVLLNLREIECLRKLKNHPNIVSMNDFWLEVVQTLSKSKRERRGRRKEQQREQMGDKRREKRQQQRREKRKEQNTNTKKRVLITLSDHKKKKLKHLSCPENALNISNITNNERNVLKKDNWKNLILLKNFKKEKHNYNFNHQIELNKYNIMCLWKILNQMCVCKNEKKNIESLLPEQLIKNFKNFLFEKYILAIYDDCSYLNNKNNKTFIFFNNNLGNILHYLWWSYLGKNGKEKKNDIFKLLKYVSDNIIKDNTNLYNIILEFRHSLIELSRFPSNELGNVILNMRIPPNGSCELSEYISNMAKINKLEIYRNKNTLEKFIFKINCNNFDVYKMWINFKNDIIYEGKDVYKEHRKINLKRKIIKKKDIWIKGKKEKHLKNTIGNKCIKKINIYYEKPIHVFVYKSLTYKRQKHHKLWRKHYNNKKNWKYCLNKHENSKKYILFSKICRLMKTQMNKFKREEKFEKKKKIAITNIKVNYNDFEQDISSFNIQIYNKKNKNQLINRIKEQYEQLSISLNPYKLTYENENILRYNEHNYLFGLKNDNEKENIYNAIYFLNFYIWIRREINEYAIISKKRQICQNSRNYQSKKKFYIKRHNQKTYFFENIIFYHYIIMLFLDIEKYKNKFVSLFQYNLYRKLLKISKRIVLMLHRIETNVICIFLLKHFEDYFIRKGIHIVQDKSDRSNKGDEIGIHKMVKIWKSMIAISLIFGKKMYKKKKNIFNFFIELFLNNIQINIFKKFEILYLIIYFYNYFEKSKQFDIEGIGDIIYVWLSLINLFYDDKGKCIKILSKIFAKLNKKLYYVYWGKLYIIMNWTTIVDTIFIRNVLSINREGNYYWVIIVLKMINYFVNVAYTLTRMDIFFIKVMIKFYTRIGSAAATNSVSKNSYNEIFNNIFTLNFMNYIIYNSYFENEKKNYDIYTKYAILFIYCFIIQAYYFDTLFNIRSLESNEIANNLFPGYNYSYKNILLFYERLGRVIKNSNNTKICKYMWRKFINMWSNSIVIKENIISCLTTSRHIYFNILMNFMKIYCLDNILHIKKKKKKMNTPIVLTSKNDLKKWKDCELTKNPKSVKKGILIKKKNRNNNKKYKKKLKETHFIYNIKKVLFKKLVNINIETILYEQNGQCYILVFGSVIKKKNGQIKVKDTKIVRDINIIRDYRIYFYNYLEYFYKNNAHISDNINLIYARKWPYNNKNAVKQFCPYFDKIKDGNRKDIVSLYGNKILVKQNFSKIGNKIKNKKNNLCKKKMRTQKSIYNSNYWREKKENKLLNGNVNIIKKYKSEKIKKKELENFFDNIVYSSENDDFKIIFENATNSNACSTVDLASPNELNTKRNNINKKLKFFKHKKNSKKQKNYKNHKSHKKIFFKSVNNANRFFVTNVEPNPIMSNNHQIADSNDIYNNFSIQKKYEYNHKNCGNIYNTKDCDENDSSYICFLINEHEGQVLSHRHKELYKNMLGMERGNILYRDNACKLKDDFSCLHDQCDNSMIKACGTNELIKESTKIKRENMDKINKMNEVNQHISLETLKYKCSFKKIDKNLIQNKKKIIIRKICQINKTFYFKYNKINDKKRIYFDSVLCKSERHKTYKKRNENIKVILLKTLKGESNEYVLTTYLTEIYSDNINDPFENSRKKINSNEIFYQKTFDMYCIEDEGEVYEEQKRVNKNNKKKKYINEMIKMDTIRTDFEDNFTNSYNKKCNILKMASNINNKNNSGKKERDIKRQFLITNKKKHENNIKIFYNLFKLEESNVNSNPQTNPYYETVIHDNEDNIFYCLYKYIQQQVYRYCNCDIDEYTSNCIDKNVNKWEWYGFIKENENYDKIKTEINSNSFYNCREKHNICNSYNSVYQLEFRKLGNASKEKNFEEKKKIIKIEFRKSFNNFKLPSLLCILKWDNFFKPHFIIRCDNFLHTYNIYFDFFILLMNLFHKGEGSNLYRFNSNKSIIYNPYLSHQIYMVTKYFISNVHKINNKLPIHLENDILEIYSYNRFLTIPNKCSFKNCGNDNNNYDQRSKKHYFTKCGILNTEKVKPSKKRRIGWDGQRQRKRKDIINTLNEENQNMFCKNKEKKEENYKKIDTNISQFSEKNPVSNIDNEKNKQNFIKNKKYKFNLYIRMEYCKDTIENYINRRTRINIKRNIEIINMIIMGLNYIHNNNIMHRDLKPSNIFISNNDIVKIGDFGLASYDYLDDHKINTTKEEEIQKDLIINKNCDKIFFCNKKKLFSNYNSVFPLENGQISDVHNTKGDYNESSISKSKKFAIQNKNRNLRSCKRIFQWWSTIGELNILSKNRRRLTKFKSGSNTIHIRKSTLDENIIVRHANKCHNLSFSQNREHIDRNRMKKCNIIKNHIIKSNKSEKMNISMNVFLRCTKTRRYFTDEDKSVETRKKCSKTSEEENGNICDTKKKKNDIGEKMDKNKIAAQKKKKKKENKHPIGRRSTNSSISSAIVVKRNAYCRLEIEKYFLSKSFQNCRSNKKKKYINIKTIKNKFCSASNKNFGAKWMRIYRKGLHHDDIQEKSADQTTEQMGGCNKTVASDFSSNLKNKKESINHTLGIGTKLYSAPEQLEGNKYTKSVDIFSLGLIIIDLFIKTETNMERTQILCNARERILPDLLIKKHPNVASLCKKMLSLDYKSRPTSAQLYNKIISAGDIFLPDKCP
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MRTIALLLAYDGTDFAGSQWQTDIRTVQGALESAWEALTQERRRIVLAGRTDAGVHATGQVAHVQTTTRHNLQTIWRGLNAHLPVDLAIQNVGEAVPDFHARFSAIQREYRYLIDCAAAPLPQLRHQVLHYAGTLDVAAMTAALKLLEGTHDFAAFTTATPAQRSTVRTMYWTRVGDYEWFERRLLAIEVAANAFLQHMVRMIVGTLLLVGRGRMTVDQFGEVLASRDRRLAGPTAPAHGLTLTAVRYPPGLIRWVEPSKRQNGTTKVEQPSSYVHEE