lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis.
Subcellular Localization:
Nucleus.
Sequence:
MLPCKKRRTTVTECLQHKGNQEENNVDLESAVKPESDQVKDLRSVSLSWDPSHGRVAGFEVQSVQDAGNQLGMEDTSLSSGMLTQDTNVPILESVDVAISQGITLPSLESFHPLNIHIGKGKLQATGSKRGKKITLRPGPVTQEDRRDHPILKEPFSEEPSEEVKEEGGKPQMHSEGEIPSLPSGSQSAKPVSQPRKSTQPDVCASPQEKPLRTLFHQPEEETEDGGLFIPMEEQDNEESEKRRKKKKGTKRKRDGRGQEGTLAYDLKLDDMLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISESEDMPMFEPKMTRSKLKEVVEKGVVIPTWNISPIKKANEIKPPQFVDIHLEEDDSSDEEYQPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQSSEMTETDEESGILSEVEKVTTPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCMDSFQSMDDSLIAFRTRSKMPLKDVPLGQLEAELQAPDITPDMYDPNTADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDLDEPDTEDFRTDRAVRITKKEVNELMEELFETFQDEMGFSNMEDDGPEEEERVAEPRPNFNTPQALRFEEPLANLLNEQHRTVKELFEQLKMKKSSAKQLQEVEKVKPQSEKVHQTLILDPAQRKRLQQQMQQHVQLLTQIHLLATCNPNLSPEASTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNLMGAMQLIEDFSTHVSIDCSPHKTVKKTANEFPCLPKQVAWILATSKVFMYPELLPVCSLKAKNPQDKIVFTKAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQLTVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPVEREEHRLPFWLKASLPSIQEELRHMADGAREVGHVTGTTEINSDHGLEKDNSELEGETRYPLLLPKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQPPSLQPSFNPGKTTSPASTHSRRAPPRAPNWCSRIPHLIQPATVLQTVPGVPPLGVSGGESFESPAALPAMPPEGRTSFPLSESQILLSSAPVPKVMLPSLAPSKFRKPYVRRRPSKRRGVKASRCMKPAPVIHHPASVIFTVPATTVKIVSLGSGCNMIQPVNAAVARSPHTIPITTLLVNPTSFPCQLNQPLVASSVSPLIVSGNSVNLPILSTPEDKAHVNVDIACAVANGENAFQGLEPKLEPQELSPLSATVFPKVEHSPGPPPADAECQEGLSENSACRWTVVKTEEGRQALEPLPQGIQESLNNSSSGDLEEVVKMEPEDATEEISGSPERDICDDIKEEHAVELDTGVASEELNSAREVKKQTVLQKEEERSQPAKTPSSSQEHPDEGTSGTDVNKGSSKNALSSMDPEVRLSSPPGKPEDSPSVDCQSVETPVGPETGGEKNGPEEEEEEDFDDLTQDEEDEMSSASEESVLSVPELQETMEKLTWLASERRMSQEGESEEENSQEENSEPEEEEEEEAEGMESLQKEDETMDEAVGDSAEKPPSTFASSETAPEVETSRTPPGDSIKAAGKGRNNHRARNKRGSRARASKDTSKLLLLYDEDILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSLQILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKIIKVLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTEEKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKETEWPDGTKDCACSCHEGGPDSKLKKSKRRSCSHCSSKVCDSKSYKSKEPHELVGSSPHREASPMPGTKEAGQGKDVTEEEAPEERESTEGTQSRTVRTTRKGEMPVSGLPVGGTLPSPREVTLTERLLLDGPPPHSPETQFPPKTGAVLYTVKRNQVGPEVLSCPKASPRLQKEREGQKAVGESEALMLVWDASETEQLPGTVEPHASFLSPVSSKTRDAGRRHVSGKPDTQERWLPSSRGRVKTRDRTSPVHESPSGIDTSETSPKAPRGGLSKDSGTQGKGPEGEQQPKATEATVCANNSKVSSTGEKVVLWTREADRVILTMCQEQGAQPQTFSIISQQLGNKTPAEVSHRFRELMQLFHTACEASSEDEDDATSTSNADQLSDRGDLLSEEELDE
The following text describes a protein:
Function:
Component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Component of the mitotic checkpoint complex (MCC) which inhibits the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20.
Miscellaneous:
MISCELLANEOUS: Present with 3170 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MKAYAKKRISYMPSSPSQNVINFEEIETQKENILPLKEGRSAAALSKAIHQPLVEINQVKSSFEQRLIDELPALSDPITLYLEYIKWLNNAYPQGGNSKQSGMLTLLERCLSHLKDLERYRNDVRFLKIWFWYIELFTRNSFMESRDIFMYMLRNGIGSELASFYEEFTNLLIQKEKFQYAVKILQLGIKNKARPNKVLEDRLNHLLRELGENNIQLGNEISMDSLESTVLGKTRSEFVNRLELANQNGTSSDVNLTKNNVFVDGEESDVELFETPNRGVYRDGWENFDLKAERNKENNLRISLLEANTNLGELKQHEMLSQKKRPYDEKLPIFRDSIGRSDPVYQMINTKDQKPEKIDCNFKLIYCEDEESKGGRLEFSLEEVLAISRNVYKRVRTNRKHPREANLGQEESANQKEAEAQSKRPKISRKALVSKSLTPSNQGRMFSGEEYINCPMTPKGRSTETSDIISAVKPRQLTPILEMRESNSFSQSKNSEIISDDDKSSSSFISYPPQR
The following text describes a protein:
Function:
Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVRGRTGGGESSGRSREAGTAGREPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGSLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGEMGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGTLSCPGERASVTAGAGLRRGVGRRGAGLADGFQPLLGPIEPQGLGLGLERPARATPRGARPGARWFPAAVCSPPSRAPLPAAFPGFLRLRAPFRSPRHRACGPPLCALRTFRGRSRPPAPVAAPSRPRDPNPSLAGRDGALGPRVAQARHAPGRSAPCTRRAAPCPYPRISKPVAVRIARTRESLGGAVAGAAWSPCVPRGGPLARRELGTTCPRASGPAPGTCPALPPSLRAASPHPPPGPPGPCPTPCPLRCPRSHPHRPRPRHRTPAACPPPHHHSAPARAGALGLPPPCAPTSRSPRGTSAPRCPRAALPRTGLPAPPATLRRCPHAAALGARPLPQLPHRRHRGGDLAGTRRGSRALL
The following text describes a protein:
Function:
ATP-dependent protein-folding chaperone for the eIF2 complex. Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MNTDYTPLVNVPIKREDIETCRFSNWYPLFKKHCPTAEIIGPLPAEFIEYLEQDGIKIPNENRSFYSEDLTINDDNEYSDWDNEDDDEEEDKVIQQEVKKEIDPLADFPELHRQIKDVITKYGAVAPKMNWSAPKDATWILPNNTMKCNEINEVYLLLNASNYIAHDLQHAFDECEDIEDQKKSSDFELVLRKWFDINPALEFRIFIKDNEILGISQRDLNYYDYLEPLVDKFRDLIEDFIDDEILDRFPLKSFVIDLYIPRPFNKVFLIDINPFARMTDPLMFSWSELLTKNEPVTPIGQEEDYEFRLIKENNVGRFACKEHSENQVPTDIVEASLNPEAIRELTQKWKELLSKQSMEEDSSSDSNEE
The following text describes a protein:
Function:
Lysosome fission factor.
Subcellular Localization:
Lysosome membrane.
Sequence:
MSKKNQQISPVLDNIVTSLLQSLSDSDESVRSTVVNSLYEIGFRQPNFVLQVACDYINKNQKIDQTHRVKILNSILQILEQTRNQLTDALSLNLIAMSISEMTRDKEVVPDWQQVASSLLVSLGLRYPSQIMDELLKRFEPGTLPHYFVMKTLGDFISSNPIPTVPKIREILSRILPVLGTIKHDNFKWVFAAALGHFADAIVQYVANIDTAPDKSLTLYSFSSEFYPALELMFSKWLGTNHEKVRLVTIEAVGSICSILSVEQLESQIQKLVVGVLSMLKKEKDLLPVTHSLCCILEVCVKNDLKLQVNELLIPIMTTLHPLVCIVPDYSNPASTKTYNEVLRCFEVIGRGYSDVLISFLNQRLENRDLRSRAGSLSIIRHIVTRLDVELADKKPLILSAIKPLIQTEPSLFIKKYLAQIIIAMAPYGYLEMEGGLTLLEFIVKGSSWYQDSEIGKAQPTQPPKKIENPDLHVTDSELRLICDNILNLITTTMPQLESILWPYLFEFILPEQYTAAIPVVTKSLTYIALSKKSVDSDDYYIDFDKEINLPKPTQIIARYFVLLTAPLRRNQLGIRILENMKAIGPILHPSICDMWDVTLPKLISYLEDHTDIETWNKNQWEELVLRLLSETIKNAADDEWTVALGNSMSEQIDHYKKDPILKRSLYKQMGLIMQKCSHKEFVKSKIEVMFTSVDYTNSLENEGCAIGLGYCGASHFDIVLEKINFYIKNSMVKKSGFFGKKGPKGIKNCILLSLGYSATYAQSALFSSRVEVHVIQPIKPSILQLKKVPKKLSSIKMIDLIGKALHPNKASTFIFKQRDELMKLLISYMSTPPPSTNNQVKIDGTNACSTLVNLEPMISLELEVQIINLSLSFFNQQVSPANATNTDSDEYKEVNSLITSVNNLLSTILYNQTTIACLNRLIGYLDPLSRSKDAHIRERSLFCILYLVKKFIEYSTDSDSMPTDKLFDSIGTTLSVLIPRCTDPEINVRRYAVESIQLILYIGFMLKNATPDNRRVKPSEVLHPLTSIRDSITTTEVNEQFSLVFEISVIISKMISLEEIPKFLEGSIKGLQDLQAFSTNGSCIIINGLIKTRGEELIEYVPILVKGLLTAMEGITSETTMNGTLVSLRSLANHHLIPVLSVLLEYPMPHSVHVIKSFQIIAKDKNLISPTLIHLMDLLNNKPVYEEKPDPKNKNRIIPQPFAIALAATCSLGEIFQLTEVEEVVKYFYHQLISTLVLRAGTCNNSLPCLIEVASTNPKAKASAISLIPSQQMLVTFRQFFKCTKEEETLLAEIESKGSFSQLETPFYHQGIIEILSVVSSHHPDLIQGIFQYLLPYQRSNHLEHRIVTISVTTELINHCKDKELIQRLINTLLNSLVDPLVKLISLKGLSNIVSAGVEQTNRYAPTVIDALSTSIDDQDETMAMECMLGLSKIFEVADEGRVAPILVNICNRIRPAFEKPNDSIRAASFQLFGSLWRFGSGSACDPFYEQIHSSLPSLIMHLNDDVQSVKNSCKKTLFQLSTLMRSQDAMDYFNNKSKGFVGDNDQPNYEEFLLDFSKLLIINYPERVNYFVMTVIEFFKSTWVNLRGNAATFIGFILGNLTEDKRTQTNINSTILTKSLVGLLAEKSPAVRKKAAESLGLLHHY
The following text describes a protein:
Function:
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
Subcellular Localization:
Nucleus.
Sequence:
MLKRNTPAWAVPKSPSVKHELKDEPGEEPDTKRIKTGNVKPILTATHGMFKENRTAAYALLNQLKKSMTIGWEDAFFWIQDTSPGSDPTEALEIFKALERVEFNKINRVFTYIPELTLTTTNEIRNHIRIHSTPTSGIPIKTLREAMPNGIEPLKDLEARGDILIMRGLTGAWKDIPLPRLGRKNVNGQELMEGGSGRWKTVFWDHLREAGRAGKRVDDEFIYSWADVPIAETDDVAKLLADQELSASSAIPAAPKATANAASKKKKKRTRALKITNTHMKEQGIDFSKDYVKPA
The following text describes a protein:
Function:
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Subcellular Localization:
Nucleus. Note=Colocalized with methyl-CpG in the genome.
Sequence:
MAAAESGEERLGEDKNEDQEGSKDKTQKHKKSKKERHDVEKLETTVSVPPPPSLFTQRDVGQQAEAGKSEPIDPEVGAALSAPESSASAKQRRSVIRDRGPMYEDPSLPQGWTRKLKQRKSGRSAGKFDVYLINPEGKAFRSKVELMAYFQKVGDTITDPNDFDFTVTGRGSPSRREKRPPKKPKMVKPSGRGRGRPKGSGKVRQATEGVAVKRVIEKSPGKLLVKMPFVAPKTEPGAPLGQAPVAKARRGRKRKSEQDPPSTPKKRGRKPATVSQSTVGTGSAAAYAAAAILTAEAKKKALKESSAKPVQERALPIKKRKTRETLEELEASTTSATETFEKRLTASTVTPTGEEAETGQKPHKHPSRKHKEADPGSSSSGTTASGVAPKSHKKRDQRGQHFKHHHHHHHHHHQHQHLQASTPSTYTPQAHQLSLGHSTHGGLENEPQDLSTSRPKAEHVACREEARTGSSSSRDSQNASKMASMTVTGESKELRDIVPPSAVPRPSREETVESRTPVSEPVS
The following text describes a protein:
Function:
Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Also found in numerous large vesicles throughout the cytoplasm of the soma.
Domain:
The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity).
Sequence:
MALKEGLRAWKRIFWRQILLTLGLLGLFLYGLPKFRHLEALIPMGVCPSATMSQLRDNFTGALRPWARPEVLTCTPWGAPIIWDGSFDPDVAKQEARQQNLTIGLTIFAVGRYLEKYLERFLETAEQHFMAGQSVMYYVFTELPGAVPRVALGPGRRLPVERVARERRWQDVSMARMRTLHAALGGLPGREAHFMFCMDVDQHFSGTFGPEALAESVAQLHSWHYHWPSWLLPFERDAHSAAAMAWGQGDFYNHAAVFGGSVAALRGLTAHCAGGLDWDRARGLEARWHDESHLNKFFWLHKPAKVLSPEFCWSPDIGPRAEIRRPRLLWAPKGYRLLRN
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase.
Sequence:
MNVIWRNYISCPRMRKVPHRYQSGCHPVAPLGSRILTDPTKVFEHNMWDHMQWSKEEEAAARKKVEENSAVRVLLEEQVKYESEASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVGQKTEEKVKELSWNHVKINAESFFSKMHCPTMPEEKNHYKESSGSSDGQSKAGSDFSKLDSEEYRERPLKTELFPGSNAAFRILEVGCGAGNSVFPILNTLQNVPEFFLYCCDFASGAVELVKSHASYRAAQCCAFVHDVCDHGLPYPFPDGTLDVILLVFVLSSIHPDRMQGVINRLSKLLKPGGMLLFRDYGRYDKTQLRFKRGHCLSENFYVRGDGTRAYFFTKGEVHNMFCKAGLDEKQNLVDRRLQVNRKKKVKMHRVWVQGKFQKPLHLTQKSSNLVFSVLSHE
The following text describes a protein:
Function:
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Sequence:
MLNTVKGLPAAPTAYDGSGLRIAIVHARWNDTIIHALLAGARATLRQQGVRDENIVVKTVAGSYELPLACKKLIEAGKTQSANAAPSMLASSTNLLSLIDGASQPQAAGQPQTAPPAASTAPFDAVIAIGCLIKGSTMHFEYICEAVSQGLMNVQLQTGTPVVFGVLTVLNDEQALLRAGIGSGEDKGHNHGEDWGLAAVELAAQYKEWEKGFL
The following text describes a protein:
Function:
Needed for flagellar regrowth and assembly.
Sequence:
MAKLVFKPIQISDMKDQVELAIPDKYKKFHRDEDAEEFEVDQEGNIIEQYQGPSIEEIEAELNRYREENEEQVRKLLEDARRKSEEIEEEGRKRAFQMIQDSKEKVKLEEDTGKAKAEQILDRAKMEVERMIKEAEMKVAEIEHEAYLKGYDAGREVGFKKGQGEVRRLIDRLGTIVGKAIDIREEIIQASEKQMVEMILIIARKVIKDEIIERKEIVLNNIREALKRIKDRDRVDIRVNFADLELTTAHKDELIKLMESLRKVNIYEDSRVDRGGVIIETDVGAIDARISTQLKEIEEAIRNAEPI
The following text describes a protein:
Function:
Regulatory component of the Usp12-46 deubiquitylase complex. activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. The complex deubiquitylates the wg/wingless-signaling receptor arr/arrow, which stabilizes the receptor and increases its concentration at the cell surface; this enhances the sensitivity of cells to wg/wingless-signal stimulation. This increases the amplitude and spatial range of the signaling response to the wg/wingless morphogen gradient, facilitating the precise concentration-dependent regulation of its target genes. Together with Wdr20 and Usp12-46 required for wg/wingless-mediated signaling in the wing imaginal disc and for wg/wingless-dependent regulation of intestinal stem cell proliferation.
Sequence:
MLTHKNNQGGRKKMQVAFVIRDAEEKRHRNGVNALQLDSINGRLYSAGRDGIIRLWNSTQTSSSEPYIQSMEHHNDWVNDIVLCCGGRNLISASCDTTVKVWNAHKGFCMSTLRTHRDYVQALAYAKDREQVASAGLDKAIFLWDVNTLTALTASNNTVTTSSISGSKDSIYSLAMNPSGTIIVSGSTENTLRIWDPRTCNKIAKLKGHTENVKALIVSEDGTQVVSGSSDGKIKLWSIGQQRCIQTISVHSEGVWCLLMTEGFSHVISGSRDRKIIMTELRNPANSVLICEEQAPVLSMCYNIDQTGVWATTWNSDIRCWKLHKTEKLCNYSYSNSNSSINNGSGDGTSSSVAPAPASNSRAPTAVPTGATTASSGKGYEVACIKGGAAIKRYHVLNDKRFMLTRDTDENVAIYDVLKIKKVEDLGKVDFEEEIKKRSQRIYVPNWFMVDLKTGMPMIVLGQDEIDCFAAWVSAEAGLPEHAEPGSDPKVNYGSLLLQALLEHWRPAPSHHHIQGGPVELENGCDGDVRGNEYFSVPKHTPIIFSEVGGRNVCRLLVKDAAGETESALLNDTVPSWVTNVVIDRTLPKFIKLPFYLLAHPSMLKQDRNKKERLIANEFIQCRKVCEHVLEKVLGSDLPTSDSNGNSNSSQNNSQSDGNSESSQIPAEERIELLCNEVLCDPNMDLRTVRHFIWKQSSDLTFHYRTKLN
The following text describes a protein:
Function:
Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors.
Subcellular Localization:
Nucleus.
Sequence:
MEYTSSPKPQLSSRANAFSIAALMSSGKTKDKESEENTIKPLEQFVEKSSCHPNLGDLPPLETHSDFSSGGGTGSGAPLCTEPLIPTTPGVPSEEMAKISCSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPDAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFVFTETVFTAVTAYQNQLITRLKIDSNPFAKGFRDSSRLTDIERESVESLIHKHSYARSPIRTYAGDEETLGEEGHSAHSRGSAFTASDNLSLSSWVTTTSGFSGFQHPQSLSAIGTSTASLASPLPHPIQGSLPPYSRLGMPLTPSALASSMQATGPTFPSFHMPRYHHYFQQGPYAAIQGLRHSSTVMTPFV
The following text describes a protein:
Function:
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.
Sequence:
MSEMIKVIDIGTTKISFAGAKIESGKLVIDFLKSYPSAGLKRGKIVDMEAMISSIKKSLQDIESTLGIRLKKAFVCSSGSDIEGICSNAAVKVKKREVTEQDVDLAIEAATAMQIPYDRQAVHILPVEFVVDGVNGIKDPVGMKALRLESKVYIITASSSHIQNLITCCNKAGIEVEDIVLQSVASSEATLSEHDKEMGTLVVDIGGGSIDMAVFYDGYLRHVATYGIGGNHITNDLAIGLKIPFHEAERIKTQFGVALPDIRFGSLKFKENEKDIEIVGLDKHSIKIPLNVIKEIIYARCEEILEVLKKEFTSIPQDISISSVVFTGGTSLMQGFISLAEGFLSIPARIGKPDTGLMTVCSEFGLDESIMEQKEEFEEIFTPEFASTIGTIIYAIKTRGFSESYSGLAKLFSKIGTWIMEKTLRKFK
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
Miscellaneous:
MISCELLANEOUS: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.
Sequence:
MKGTVGELGEFGLIRELTSRLTTTPAVRVGPGDDAAVVAAPDRRVVASTDILVEGRHFRRDWSTAYDVGRKAAAQNLADIAAMGAVPTALLLGLVVPAELPVTWPTELMDGLRDECQVAGASVVGGDVVRGDTITVSITALGDLRNQEPVTRAGAQPGDLVAVTGWLGWSAAGFAVLSRGFRSPRAFVEAHRRPEPPYHAGPAAAGLGATAMCDVSDGLIADLGHIAEASKVRIDVRSGQIDIPSQMNDIGQAVGVDPMQWVLTGGEDHAIVATFPPDVKLPARWKVIGEVLNPSALPQVTVDGAPWTSKGGWDHFGGDVES
The following text describes a protein:
Function:
DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis. Catalyzes proteolytic cleavage of the hmces DNA-protein cross-link following unfolding by the brip1/fancj helicase. Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as top1, top2a, histones H3 and H4. Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs. SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs. May also act as a 'reader' of ubiquitinated pcna: facilitates chromatin association of rad18 and is required for efficient pcna monoubiquitination, promoting a feed-forward loop to enhance pcna ubiquitination and translesion DNA synthesis. Acts as a regulator of translesion DNA synthesis by recruiting vcp/p97 to sites of DNA damage.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to sites of UV damage via the PIP-box. Recruited to stalled replication forks at sites of replication stress.
Domain:
The UBZ4-type zinc fingers mediate binding to 'Lys-48'- and 'Lys-63'-linked polyubiquitin.
Sequence:
MMEDEDFLLALRLQEQFDQETPAAGWPDEDCPSSKRRRVDPSGGLDVIPFTQPRAERPLSIVDESWETLDPNPDVRAMFLQFNDKFFWGKLSGVEVKWSPRMTLCAGVCSYEGRGGLCSIRLSEPLLKLRPRKDLVQTLLHEMIHALLFVTQNNRDRDGHGPEFCKHMNRINQASGTNITIYHSFHDEVDVYRQHWWRCNGPCQNRRPFFGYVKRAMNRPPSARDPWWADHQRSCGGTYTKIKEPENYGKTGKSDKQRDKMPATEMPKKSKPPSSTSSSGSQDIRNIIPFSGRGFVLGGNAQIPTNKQIQSPPKAPPEPLHSPPDSPLLPRLQLNEDNLKRLSSGTSNIPRKRSVGNTNAFINVNGSPVRISNGNGSGGKQRSVRDLFQAIVLKSPDRGASAVGSSKSSTDASTADYRSNSALDAKPSGKTSLITDHLSYTISGPKTLSAESNISKYFGGSAKTDVQDSKLKTFGSPQKSAIGTPGYVSKAFGSNQRPDSTSSGIRNTGSPQRSHASATSGSSFKHFRGPAKPESNFPSPRNIGSPRTSGTTPSGAKKRSWEEHNSERVFDYFQRTVGESATSTDKKREEVRSEAPPPVRDQQANNPPAQITVHCPVCHIRLPESTINDHLDSCLL
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for TAP42-associated PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex. Involved in the regulation of cell cycle progression, mitotic spindle formation, bud morphogenesis and DNA repair.
Miscellaneous:
MISCELLANEOUS: Present with 4590 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSLDRVDWPHATFSTPVKRIFDTQTTLDFQSSLAIHRIKYHLHKYTTLISHCSDPDPHATASSIAMVNGLMGVLDKLAHLIDETPPLPGPRRYGNLACREWHHKLDERLPQWLQEMLPSEYHEVVPELQYYLGNSFGSSTRLDYGTGHELSFMATVAALDMLGMFPHMRGADVFLLFNKYYTIMRRLILTYTLEPAGSHGVWGLDDHFHLVYILGSSQWQLLDAQAPLQPREILDKSLVREYKDTNFYCQGINFINEVKMGPFEEHSPILYDIAVTVPRWSKVCKGLLKMYSVEVLKKFPVVQHFWFGTGFFPWVNIQNGTDLPVFEEKEEESIEQANAGSPGREQTSTRFPTSTSMPPPGVPPSGNNINYLLSHQNQSHRNQTSFSRDRLRR
The following text describes a protein:
Function:
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Prevacuolar compartment membrane; Single-pass type I membrane protein. Note=Cycles between the Golgi apparatus and the prevacuolar compartment.
Sequence:
MLHHCVLHIICALFFFLPLGGADSNYAISKLGTASKSQKSLIVNFSKSRNILLLDATGTLLLSQDDGTSWQDAVSNSDPAVVEQLYQHPFEDDIVYAITKESDILVSEDAGLTWFTVTMPPKTVIEAQPFEFNARQSQSVILNAARCESGSIWTGVTCYPFTYYTYDNFRNLDSVHDSIVSCTFAVGTVEFAGQDEDQMLCLIRENDVDLQAPFNQQLISVSKGFESIDYVVFDPYYGSLGTESVVAVGQYLVAAVVDVNSKKLKLHYSTDGQIWVPITFINAPSIGSLTVTRSTSLTLGVDVESTNLKNPVGEFYTISPSDAYAVRRLNDTNRDTRGYVDVIELDYLNNTILANTVANTEDLYKRASRQKELVTKISHDGGFSWTQLERPVDLECEGDDAEDCHLHLHLGITETKFGSLSPDRLPGVIMALGSVGTHLQPLSDSDLFISEDAGRSWYLSLQGPHYYSSSAYGSVFVAVKANENSKLIYYSLDFGREWESLEVEASFRALEIIPPKSLDSLTFLIRAKVKKEESFIAIDFSSILSRECTFDEKKVANGDFELWYPFVMDDTPQCLMGRIEYYLRKKRAVSCVVRNEVPVHSFVEQICTCESKDYECSTYFEPSDHFTCEVNPESLDPLCRVDPDATLQLKPYRILLGNSCVPKKKEEKEKSISMKCPKLDHRKDIHMYHHKIQDTISNIVYMEGTGEPDSTTELLLTSSQKVLFSYDFGEEWLEFDEKKNPSFYGIYPHAFLKDTAFLLTKDRKIYFTNNKGRSFYRLDAPSPPNVVGYPVFNFHSLHPNWVMYMGSENCDDSFYEDCRSVVYLSFDSGASWQKLPDELEYCSWVLGERLLVEDKLLFCNRRRAAADSIGYDLVASTDFFETEASSIRENVLGFLLADEYVVIAALTDDETSLSMHVSVNGRNFSPCIFPQNIQVHSQQAYTILSSKTRALFIHVTLSSRKGAEWGSVLKSNSNGTYFVNVLDKVNRNELGYVDFEKVEGLESIALANVVLNSDEAFNGEEKRLGTLITFNDGIDWERLYLIDAKKHYPHCDSKCSLHFHGFTERSVFSDPTSSSAATGIIFGIGSYSYYLEPYETSQTFISRDGGVHWELIFDSPHQWAFVDSGSLLVAVPSTNKTNILYYSEDEGRSWIAYQFAEDTYLIEDLSTAPSGNSQRILVLAKGKKSSETISFTVDFSHLRSRVCVFDFNDQRDFASWTPAGRDGKPMCLFGHKTAFYRRKPGRDCFIGNTPYVSDTIISNCQCTRMDYECNYNYERIAGGTCRLVSGAEPPLQQEEQCAAEGAIEWMEPTAYKRIPLTTCEGGLVLDESTTHPCPGKEDDYHKIHPGTPVWLIIMLVLLSVFLSTIVGAWVYTKAQSYLVGAIRLGEDPADETVFAKLMTRIESVVTAVPIFFSAAYHLVRSVFVRQDRSMSLDDYDNFEGMEDAAFLEVDDIETSE
The following text describes a protein:
Function:
Galactose-binding lectin. Displays antibacterial and hemagglutinin activity. Inhibits the growth of L.infantum promastigotes by damaging their membrane integrity and inducing cell apoptosis via the production of reactive oxygen species (ROS). Inhibition of L.infantum promastigotes appears to increase with time (MIC=1.2 uM/ml after 24 hours, MIC=0.9 uM/ml after 48 hours and MIC=0.6 uM/ml after 72 hours). Agglutinates Gram-negative and Gram-positive bacteria including E.coli, S.aureus and S.epidermidis, and inhibits biofilm formation by S.aureus and S.epidermidis. Displays hemagglutination activity towards all types of human erythrocytes (O, A and B) and rabbit erythrocytes.
Sequence:
TYAEVESFGVGQSATAVYTAPGDGRDLNITIDADGGYVIHMDYRFDWGGNPSTGKPWEDILILNSKPAQTWGPQQHVNNFYFTPGTHVTLGDKSNDGHFAIIADGIQVATYDHRLPVNSVKEVKFSTTAGSGTDIWDLLLLP
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MPQLVPFYFINQVTFAFILLIVMIYVFSKYILPRFVRLFISRVFISKL
The following text describes a protein:
Function:
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Sequence:
MQVPLIRLQCGVNSYDWGKVGNDSAAAKFAAATPVDDFSIQEDKPYAELWMGTHPSNPSKDLATKRTLLDLVQDNQALLSKDVSEKFGEKLPFLFKVLSIGKALSIQAHPNKKLAEQLHQRDSKNYPDDNHKPEMTIAITPFDGLCGFRPLVEISHFLSTVPSLKKLVGPSEAEDFQSAIKGQETSDKQEDGEKNKKALQKVFTALMNAKKEDVEKASEELVAAAEEEGENFAGGGGRSNEGKELADLVIRLNKQFPGDIGLFVQFFLNYVKLEVGEAMFLKADDIHAYLSGDIIECMAASDNVVRAGFTPKFKDVDTLTSMLTYSYAPISEQKMDPVDYPYATLNATAYSSGSSAILYDPPIAEFSVVKTDLKKKGAKATFEQISGPSIFICTTGNGKISVGPEVEEVKPGYVYFVGATAEVVLEAKDEDFTTFKAFCELQGKGEADGKEKL