lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Deaminates adenosine-37 to inosine in tRNA-Ala.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEEFTLDRNSNVGNLIALAVLNKFDELARHGKPIIRANGVREWTTLAGVVIQKKMENEFICVCLATGVKCTPAGIIKNEQLGSVLHDCHAEILALRCFNRLLLEHCILIKESKKDTWLLEVADNGKFTLNSNLLIHLYVSECPCGDASMELLASRLENNKPWNLTVDSEKLMRGRADFGLLGIVRTKPGRPDAPVSWSKSCTDKLAAKQYLSILNSQTSLICEPIYLSCVVLYKKVIVKSAIDRAFGPFGRCAPLAEFGEKDNPYYFHPFTVLETDENFLYSRPLNQAEKTATSTNVLIWIGDKMQCTQVIHNGIKAGTKAKDVEKSQTLICRKSMMNLLHQLSQSLTNEKNYYEWKKLNIKRCQQKQILRNILKNWIPNGGNEFQWI
The following text describes a protein:
Function:
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Subcellular Localization:
[Isoform 2]: Cytoplasm, cytoskeleton.
Domain:
The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Sequence:
MEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEELDHALNDMTSI
The following text describes a protein:
Function:
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.
Subcellular Localization:
Nucleus.
Sequence:
MKECKKCKSNEYTNKQLVMMINECGHPLCKNCVDNIFALNSGNCHVCNRVLRKNNFREQIYEDPLIDKETFLRRKLRKIYNLKQDDFENLREFGDYQERFETVVYNLVFETNVNETNAEIQAFEEKHKEQIDRNKRRLDDDQKWIEDQLREERAMKARMTDHMEMDAKEQEAASAVTDTRKIMDELRDSNVAAEVILDRERKKQIEKELEEKEEQEKRKRRNKEMLQTRKRAAENMSFNTVIRVAGRAYVHQPLELVINGPPMPNVSEIEALGYLAHIRQPTAEYIAGGYTPMLGCSRALFEARIDLFSF
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MSVDKYVLILMNSKQTYIHRFDKINTPDVIIVIQKFRQQEDQDEITLSQSLKITRRFAKYLLKQAGHYDRVRKAQKEYQNLSKRIGDLTKIFSKYEIDGLIQYKDEQNDSFTKFMKDAGLYDHQILQLYITYKFGAQKGAAFTLDEFLLGMIRLKCYTIKDLKNLCPDLLKKIQKENKYKKLYSYYFKVISQGKNVIRFSEAITLWDSLLKGQFKEIIDFISFCKAKPADFQNQTKVSFDLWCQVWKFFETIGNDYQKFDENDAWPLLIYEYVQFKIK
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U16 and U17 in cytoplasmic tRNAs. Affects the level of some mature tRNA and thereby the total cellular translation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAEEKPLSKQTKKKGFDFWRNTLKSARYVVAPMVDQSELAWRMLSRRYGAELCYTPMFHAGMFIRDPIYRSEMMQTCVGDRPLIVQFCANDPEVFVQAALLVESECDGVDLNLGCPQHIAKRGHYGAFLQDEWELLEKMVKLAHEKLSVPITCKIRVFDDVQKTIAYAKMLESAGCQLLTVHGRTREQKRELTGLADWDQIKAVRENLNIPVFANGNIQYLSDVTRCLEYTGCNGVMTAEGNLSNPALFTGSQPYVWSMANEYLELATKHKASLSAVRAHLFRLWHKR
The following text describes a protein:
Function:
Catalyzes the transfer of coenzyme A from propionyl-CoA to succinate. Could be part of a pathway that converts succinate to propionate.
Sequence:
METQWTRMTANEAAEIIQHNDMVAFSGFTPAGSPKALPTAIARRANEQHEAKKPYQIRLLTGASISAAADDVLSDADAVSWRAPYQTSSGLRKKINQGAVSFVDLHLSEVAQMVNYGFFGDIDVAVIEASALAPDGRVWLTSGIGNAPTWLLRAKKVIIELNHYHDPRVAELADIVIPGAPPRRNSVSIFHAMDRVGTRYVQIDPKKIVAVVETNLPDAGNMLDKQNPMCQQIADNVVTFLLQEMAHGRIPPEFLPLQSGVGNINNAVMARLGENPVIPPFMMYSEVLQESVVHLLETGKISGASASSLTISADSLRKIYDNMDYFASRIVLRPQEISNNPEIIRRLGVIALNVGLEFDIYGHANSTHVAGVDLMNGIGGSGDFERNAYLSIFMAPSIAKEGKISTVVPMCSHVDHSEHSVKVIITEQGIADLRGLSPLQRARTIIDNCAHPMYRDYLHRYLENAPGGHIHHDLSHVFDLHRNLIATGSMLG
The following text describes a protein:
Function:
Transmembrane transporter that exports citrate across the cell membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MASPQTPSKEGDTGLKGGLDVVATNTTGEVPYSVFTKAQKRYIVFFASWAGFFSPVSSQIYFPALNSIADDLGVTSALINLTLTSYMIFQGVSPMFVGDFADKAGRRPAYMVCFLIYIAANIGLALQDNFAALFVLRCLQSAGSSTTIALSAGVVSDIAIAAERGSYMGFVTAGSLLGPAMGPVIGGLLSQYLGWRSVFWFLTIFAGAFLVPFVLLFPETARAIVGNGSIPPPKWNIPLLTLFQARKEPQPEDFDWPKLRFPNPIRTLSIVFQKDIAIILIANAILFAGFYDVTAAIPSIYNELYGLDDLYIGLCYVPFGLGATVASIATGKLLDFNYRRLAKQLNVPLQETRARNLTHFPIEFARLQVALPLLTLGAFTIIAFGWCLNYGVHLAAPTTILFLMGLTLTGAFNTVSTLLVDFYPSNASAATASNNLVRCLLGAGATALIDPMLEAMGRGWCFTFIALVMLCTMPLLCVVMRWGPRWRNERQAKIDAATTGNCQN
The following text describes a protein:
Function:
Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. This is not required for transcript stability or translation but may maintain mRNA integrity by protecting 3' termini from degradation.
Subcellular Localization:
Mitochondrion.
Sequence:
MNSLVRRSAQQLSLWRTYCIKHNASEAASPGRNAGRPNYEEFIGRHQRQAQCSIVVQVSSEKSYEELYNYCSSFGSIMGAHHYCVRQDETLHYILLEYATSDEAAAAIGAGVTNGELSGVPVRSPFLWFRAAGGGRRSPKLVANTAPALLSLDGTRQVDQRHLLGLLRGAADIEEQVQQLYEHTRLNELGIRMRFLAALQVQQAIAGMFPAAQAQPFGSSVNGFGRMGCDLDLILRFDSDMGAKIPLEAAVPSRLVYHTKENLSNGRSQTQRHMECFGDMLHLFLPGVCHVRRILQARVPIIKYHHEHLDLEVDLSMSNLTGFYMSELLYMFGEMDPRVRPLTFTIRRWAQTCGLTNPSPGRWISNFSLTCLVMFFLQQLRQPILPTIGALAKAAEPGDSRVTEDGINCTFTRNVDRLGFRSRNQSSLSELLLQFFEFYSQFDFHNRAISLNEGKPLSKPDHSAMYIVNPLEQLLNVSKNVSLEECERLRIEVRNAAWVLESEVENASVPEGDGQELSCGLLNLFKHPEKAVIRPNMFFKPRMVEVSDLFEQKEAGATSSSTPPTPAITYKSASVRQQVQSIKAATRSELKQLRGSGSSVPTSSPNNRRRSR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of the transcription factor ICE1. Acts as a negative regulator of cold signaling pathways. Probably involved in recruiting the NUP107-160 subcomplex of the nuclear pore complex to chromatin (Probable). Controls flowering time in response to ambient temperatures (16 and 23 degrees Celsius) and intermittent cold, probably via the regulation of FT and TSF levels.
Miscellaneous:
MISCELLANEOUS: Loss-of-function mutation (hos1) in the gene shows an early flowering phenotype due to a constitutive vernalization and a reduced freezing tolerance without cold acclimation.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Nuclear after cold treatment. Cytoplasmic when plant are grown or returned to normal growth temperatures.
Domain:
The RING domain is required for E3 ubiquitin ligase activity; The C-terminal part of HOS1 is involved in the interaction with ICE1.
Sequence:
MDTREINGFASAARSISLPTQPNYSSKPVQEALKHLASINLRELCNEAKVERCRATRDLASCGRFVNYVLNPCGHASLCTECCQRCDVCPICRSTLPKFGDRLRLRLYYECVEAGLISRTHEEASQDSDEDEHQLAADVHRLYSLFDVAMNNNLISVVCHYITNVCMDETAVSSDPVIAFLLDEVVVKDWVKRTFRSTLAELQEIYNLETKEMQAWLDKLLRCSKQVAGICSVLEVMESAFKGSVSPQLQDVQTLRENIGKTKQHLDIMVWCIRHGFLDDVRSRYSNFTSWNALVGERKSNAVKRAWPDAVDQSSDCSVQSASLFIEDALENLEREPEYSQEIGADLEVGRLQKDKRSFLRSKIEGTSGSYPFENLRTAADMLFLHGGSDLVVAKQAIFLYYLFDRHWTTPEKYWKHTIDDFAATFGITRHSLLESFVFYLLDDHSEEALQEACRILPEICGPETYPKVAQVLLERDNPETALMVLRWSGRDGVSELVSIGEAVTALRVRVECGLLSEAFTYQRTLCLKVKENNLKNGAVKHASDDLDIWSWTEWMEILVNEFCCLSIRRNLVDRIIELPWNPDEEKYLHRCLLDSATDDPSSAVGSLLVVFYLQRYRYIQAYQVDLRLQKIEEAFVSDNQIGEEVMFRMRSQSHWRKELVDRAIDILPVIQQQQVRSGQFSEMEDASEGAKKSDLPDAPDMITSSVPFATTNSVFLQSANNARAREPVANNGSPFQPGHMIGNASHDLSHGRLFTNANRGQKSEVRSVTKNLKFGEMSTPFKDLNRARGNSQLQGKRTEESSPEVNVDRYIENNMSSPYLRRITANNPVTVKSSSNHLNGSSQKPESTFFGTRMQPDKDNFVDLDDPMDMSSSLKDNNNNVLATESRNNSGGLRWRSDETSDDEDELTSFGSMPVKGRRRRRFAAR
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Sequence:
MAFSIPPLPWGYDGLAAKGISKEQVTFHYDKHHMGYVTKLNAAAKSNPALAAKSVEEIIRTEKGPIFNLAAQIFNHNFYWESMSPNGGGEPSGKLAEAIRASFGSFAKFKEEFTNAAVGHFGSGWAWLVQDTTTKKLKVFQTHDAGCPLTEADLKPILACDVWEHAYYIDYKNDRPAYVQTFWNVVNWDHAENQFTRKRNPGAPHSDL
The following text describes a protein:
Function:
Transcription activator that binds DNA on 5'-ACTCTAC-3' and promotes auxin homeostasis-regulating gene expression (e.g. YUC genes), as well as genes affecting stamen development, cell expansion and timing of flowering. Synergistically with other SHI-related proteins, regulates gynoecium, stamen and leaf development in a dose-dependent manner, controlling apical-basal patterning. Promotes style and stigma formation, and influence vascular development during gynoecium development. May also have a role in the formation and/or maintenance of the shoot apical meristem (SAM). Modulates root growth.
Subcellular Localization:
Nucleus.
Sequence:
MGMVGLRDVFLVAPAYHHQNAGVISGSDHMNSNAAAAAALGVGVIPLLTAGTPQQNVEDSDINFLGNNRRWQNNNNNHETQYLHFKSTNQTTVGTSSNNSGSGSGASGTATCQDCGNQAKKECKQRRCRTCCKSRGFDCSTHVKSTWVSAARRRERQVMPTGANPTAGSSLSTSSGTKKPRIVGSQQQQQQQATSHTSTSNTPPQSFETSSSRQDGGGSREAWPGQVRAAAVFKCVRVTAVEDGDDEYAYQAVVKIGGHVFKGFLYDQGLEPKEGFPSMSDLHLGGSANNHNGVSASAPILDPPNVVYGGGGGSGGGFYS
The following text describes a protein:
Function:
Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP.
Sequence:
MELKATTLGKRLAQHPYDRAVILNAGIKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFVLPDEKVVRLHGTEWGETQRFYHHLDAHWRRWSGEMSEIASGVLRQQLDLIATRTGENKWLTREQTSGVQQQIRQALSALPLPVNRLEEFDNCREAWRKCQAWLKDIESARLQHNQAYTEAMLTEYADFFRQVESSPLNPAQARAVVNGEHSLLVLAGAGSGKTSVLVARAGWLLARGEASPEQILLLAFGRKAAEEMDERIRERLHTEDITARTFHALALHIIQQGSKKVPIVSKLENDTAARHELFIAEWRKQCSEKKAQAKGWRQWLTEEMQWSVPEGNFWDDEKLQRRLASRLDRWVSLMRMHGGAQAEMIASAPEEIRDLFSKRIKLMAPLLKAWKGALKAENAVDFSGLIHQAIVILEKGRFISPWKHILVDEFQDISPQRAALLAALRKQNSQTTLFAVGDDWQAIYRFSGAQMSLTTAFHENFGEGERCDLDTTYRFNSRIGEVANRFIQQNPGQLKKPLNSLTNGDKKAVTLLDESQLDALLDKLSGYAKPEERILILARYHHMRPASLEKAATRWPKLQIDFMTIHASKGQQADYVIIVGLQEGSDGFPAAARESIMEEALLPPVEDFPDAEERRLMYVALTRARHRVWALFNKENPSPFVEILKNLDVPVARKP
The following text describes a protein:
Function:
This toxin kills sensitive strains of yeast.
Miscellaneous:
MISCELLANEOUS: The full activity of this toxin depends on NaCl or KCL. Its maximum activity is found at 2M salt solution.
Sequence:
MRKETLIGLAFITANVIAWSLRWRMQKSTTIAAIAGCSGAATFGGLAGGIVGCIAAGILAILQGFEVNWHNGGGGDRSNPVKRSSDSFSIVNHNGEKVDSYAHLVPGKVGKVIIDNIELSAIRYANNHTSLGYHFTSDGSGPAARGEATTIWGVGADEAIDKGTPSKNDLQNMSADLAKNGFKGHQGVACSTVKDGNKDVYMIKFSLAGGSNDPGGSPCSDD
The following text describes a protein:
Function:
Monocarboxylate-proton symporter; active in acidic-to-neutral pH range. Transports formate, acetate and L-lactate.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPREKPRADEIAIEMMSVCEDETEVEQDPRELYEEEMKEQQQIDCSKQQKEVVAIEELEKRNINKHFFSIQPNTQIPVISSNYIAPVDTSRLLVLIGKTKATYPIMKMFSLSVLAGMLLSVGGLLSITIGKGIPSSDIGIQKIVFGFFNSVGLNLVVLCGGELFTSNCAFLIPGFMEGAYSRWLFFKTHFVVYFGNLVGSIFVSTYFGKLLGSFESPMYLSAVKQIGETKVAMNWGRALLSGIGCNWLVCCAVYFSASAKDLLSKLVVISFLVLTFASLEFENCVGNMFLLSLSHMYGGNFTLGQWILNNLIPVSIGNFIGGTFLLGIPLWYVHVSNVYNIPFLDPLYQQSQAKTQ
The following text describes a protein:
Function:
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Sequence:
MLEIVLASQNSSKLAEMQELLRDLEIKFIPQTEFSVPDIEETGSTFVENAIIKARHAAKQTGLPALADDSGLTIAALNSAPGVFSSRYAGKNATDAERIQKVLEALEAADDSDRSASFHCVIALMENENDPAPLICHGVWEGEIAREPRGKNGFGYDPIFYVPSHQRTAAELDPQEKNAISHRGQALEQLSTVLTEAFLV
The following text describes a protein:
Function:
Catalyzes the penultimate step of the biosynthesis of cholesterol, the dehydrogenation of lathosterol into 7-dehydrocholesterol (7-DHC). Cholesterol is the major sterol component in mammalian membranes and a precursor for bile acid and steroid hormone synthesis. In addition to its essential role in cholesterol biosynthesis, it also indirectly regulates ferroptosis through the production of 7-DHC. By diverting the spread of damage caused by peroxyl radicals from the phospholipid components to its sterol nucleus, 7-DHC prevents this form of cell death.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence:
MDLVLSAADYYFFTPYVYPATWPEDNIIRQTISLLIVTNLGAYILYFFCATLSYYFVYDHSLMKHPQFLKNQVSREIVFTVKSLPWISIPTVSLFLLELRGYSKLYDDIGDFPNGWIHLMVSVVSFLFFTDMLIYWIHRGLHHRLVYKRIHKPHHIWKIPTPFASHAFHPVDGFLQSLPYHIYPFVFPLHKVVYLGLYVLVNVWTISIHDGDFRVPQILRPFINGSAHHTDHHMFFDYNYGQYFTLWDRIGGSFKHPSSFEGKGPHSYVKNMTEKESNSFAENGCKGKKVGNGEFTKNK
The following text describes a protein:
Function:
Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Subcellular Localization:
Secreted.
Sequence:
MNSYFVIALSALFVTLAVGSSLNLSDEQKDLAKQHREQCAEEVKLTEEEKAKVNAKDFNNPTENIKCFANCFFEKVGTLKDGELQESVVLEKLGALIGEEKTKAALEKCRTIKGENKCDTASKLYDCFESFKPAPEAKA
The following text describes a protein:
Function:
RAB5A effector molecule that is involved in vesicular trafficking of early endosomes. Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility.
Subcellular Localization:
Cytoplasm. Early endosome. Nucleus, nuclear body.
Sequence:
RGRGLLGVRTGGGWAGSDAGDFLARYRQVSSKLRKRFLRKPNVAEAGEQFAQLGRELRAQECLPYAAWCQLAVARCQQALFHGPGEALALTEAARLFLRQERDARQRLACPAAYGEPLQAAASALGAAVRLHLELGQPAAAAGLCLELAAALRDLGQPAAAAGHFLRAAQLHLPQLPLAALQALGDAASCQLLARDYSGALAVFTRMQRLAREHGSHPLRQPPPAPPPPAPPLPLAPPAAASTSSASASTSSASASSSSASAPLGPAAAAPALPAALLPAAPAPTPTPAPATLGAFSDVLVRCEVSRVLLLLLLQPPPAKLLPEHAHTLEKYSWEAFDGHGPDGAGQLPDELFLLLQSLVMATHEKDTEAVKSLQVDMWPLLSAEQNHLLHLVLQEAVSPSGQGV
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MRFAGLGGATRKEQTRDELLEAVRAERAARSGAKAKAKSAVVIQRAWRGHVARRQLRAALVSEWATSFGPLVTAPTAQIAAADVAGKLLPPFLFLLKPPPTPAAGSSAVGGPGKNAGSRVAGGAAAAAAAAAARDVVLLPPAGSSLSNMIRGTLALLLRTCSAANPQDNYLALAVAAGAPGGTPGGAAVAAVAGAKAAWTDQAWRLLVTCCRLVCAPRQPVGGSSSSSTGGAAPAAATAGGDPVVDAAALRLAALLTDAAQWKILAAGPGPQRSAAEASAAQLRSRLALQPQPLFAALARLLAAQQAQQQAQQPQAQQPQAQAPSPHQQGAQQLQQQQLSRLLGLVLAVLQSALDLEQRAAAVTATAATTATAPPPGSSTNNGGGGGGSGSTAALDAEAAQRCLAAFAQLVLVAPQAVALVPGDMQARLREPRVFAALCRCVRQLLKSRALRGAPEAGWCLTNLLQLLLGPHMRGGVLPDAATAAVRGGGTDSKAAPGAVWVLTPPPDAVWGPGGEAAMELAETAAALMAHMASNKLVATAELSAAVAGLWPLGQRGLLLPLLTALEVRLGGVESFTDLCCAAMDLGSRLATAFADSDVRAAGFPSVLNALAFSPALLPRLWKWLCFSLGLPRECPAAATRGLDVAALAGGYAGVAPRKARVLGLFCRVYAQLLLVLDDGEFYDLQQPLELAASRAVGTSLNSLVFHTYLPKPPPDGSRPPPPPAEGDPAYALLVEWAPRLLRALYERDVRRPYCQSLLWLAPYTEMFGTEDQPPPPPPPRRRPADDDDDDDDDFDPSAPAPGPDPAAARIGPFTAGTVLTSLMYGGTGGEDDDEGARGGGGAGTSGGSAAGGAAPALQTKAGEGCRPSSMAALMKATPQAVPFSRRVDLLRALLAEDKARGRWDRAPHAGGMQPIKVTIRRASLIEDAYAGLAQAGSGLKARLQVTFINEAGMTEAGLDFGGLQKELLERVVSAGLDANYGLFTSTPDGLAYPNPAAERIPGGLALLEFMGLMFGKALYEGILLPVPFAHFFVARLQGRQPLFDDLATLDPELHKNLLMVKRYEGDVTDLCLSFSAETDYFGTPVHHELLPGRGDEPVTNDSRLLYCHLLADWHLNGKLGPPAAAFARGLFNLIPQASLRLFNPREFNQLLSGAAADGPGGAGVAALDVADMRRYAKYSGGYRHDSTTVKLFWRVVAELTPAQQAALLRFVTSCSRPPLGGFRYLQPPLTLHKVDCDAGLFAAIGGRDVDRLPSASTCYNMLKLPNYRRAATLKAKLLYSITSGAGFELS
The following text describes a protein:
Function:
Probable GTP-binding protein that may be involved in cell development.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSAIVQVINGEGEFESAGVQSFVDKNELAQCRTNYAVVAIMGPQSSGKSTLLNYVFGTDFKMMDAMEGRGQTTKGIWMSKSPKVADTTVLVMDLEGSDGRERGEDDTNFERQSALFALAVADVLLVNIWCHDIGREHGSGKPLLKTIFQVNLKLFAPEPDRKKTVLLFVIRDKTKTPLAKLTEVLEADLDRMWDSIAKPAAYSGSKMTDFFEVQYAALSHFEERYEDFQADAVHLRRRFAPDAEDTLVRGDEKLPGDAFALSIHNIWDVIRSQKDLNLPAHKVMVANIRCQEILEDQLRAFTGDQAWAGLQEAAGLGAVEGFGAQVAGLMDSCVKGYEAEALYFDSHVREDKFQELSKRLLAAVQPLYQAQVAAQTAAVLTGFEKELKLALLPEGAASSGGGFVAAAAACRAAAVKEFGMAFKKHLHIQGTPWDGAAEAAALEAALDSHIGKVRSEHVAAAVARAEKQLRSLLSAPVIALLEVCGPGMWPKLYGVCREAAAAADKQLLAGLAGYGLGAAEAEALSEGLRARARASMEGHVREAALTRLSRMKDRFQEVFSQDESRAPRMWGARDDVPAIAAAARLAAANVLAQLAVIRPPPGEGGKAQQGEQGDVIEAAVLQLARTSSDAASAPAPADGAASSSAAAPAAAAASSHGAAGAALDLLSAAAWPGVSDESRVLLAPHDVRTSWREFMSYSNVAVQQALSAQQANRLANNRLPPLWAIVAMLALGWNEAMALLFNPLLLLVVGVLVLFLRSLYVELDVERELARGALPGAISLSHKVVPACKSVLRKTTESVQQILHSIQEGQGAAAVGEGRAAAYAVDGAPNSSSNSSSRAGSGTPGPGRYTELTRRGATAAAAAAPNSPAEFTDLRAEGKKGQ
The following text describes a protein:
Function:
Modulates negatively TGFB1 signaling in keratinocytes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MRSRRLLSAAHLLCLCAVALAAPGSRFLVTAPGIIRPGANVTIGVDLLENSPPQVLVKAQVFKIASNKSRSILEAEGVFHRGHFKTLVLPALPLSSADKIYELHINGQSENEIVFSNRTRLTFESKSISVLIQTDKAFYKPKQEVKFRVLTLCSDLKPYRTSVDIFIKDPKSNVIQQWFSQKGDLGVVSKTFQLSSNPIFGDWSIQVQVNDQQYYQSFQVLEYVLPKFEVTVQTPLYCSLKSKQLNGSVIAKYTYGKPVKGSLSLTFLPLSFWGKKKNITKSFEINGFANFSFDNYEMKKVMNLKPLTDVSEGSYENVDPSFPGPAEIIATVTESLTGISRMASTNVFFKQHDYIIEIFDYTTVLKPSLNFTATVKVSRSDGNQLTPEEIENDLVTVVTQRKNNHPESQRDQEMDYIQTVNYTIPQNGIIKIEFPVMSISGELQLKAYFLDGTSSVTVHSMFTSPSKTYIQLKTRDEYIKVGSPFDLMVSGNRQFKDLSYMVISKGQLVAAGKQSSRTFSLTPEASWAPKACIIAYYIAEDGEIINDILKIPVQLVFENKVKLFWSKPTVKPSDKVSLRISATQSDSLVGIVAVDKSVTLMENSNSITMETMVHELELYNTEYYLGMFMNSFAVFQECGLWVLTDATLIRDSIDEVYDTEEYSERFAEENEANLVDFEDASSVNNVHVRKNFPETWIWLDAYMGSKIYEEFEVTVPDSITSWVASAFVISEDLGFGLTTVPAELQAFQPFFLFLNLPYSVIRGEEFALEVSIVNYLKDTIKVVILIEESDSFDILMTSNDTNGTIYRKTVQVPRDNGVTLVFPIKPTHLGEIPITVTAASPTASDAVTQTIVVKPEGIEKSYSKSVLLDLTDSNVESKQQSMRFSFPPDTVIGSERVQITAIGDILGSSINGLSSLIRMPYGCGEQNMIYFAPNIYILDYLTKQKQLTVNLKEKALSYMRQGYQRELLYQREDGSFSAFGDIDSSGSTWLSAFVLRCFLEADYYIDIDQDVLHRTYTWLNAHKKFNGEFWEPGRVIHSELQGGTKSPVTLTAYIVTSVLGYKKYQPNIDVQDSIKFLEFEFSRGISDNYTLAIISYALSTVGSPKAEEALNLLMQRSEKEGDTQFWLSSGPALSGSWQPRSVDIEIAAYALLAHTLHHVSEGIPVMRWLIQQRNSLGGFVSTQDTVVALKALSEFSALVHKENTDIQLTVTGPGIPRSIHFRIDSQNLFLLHQEELHALDPITVNVSAHGSGFAICQLNVDYNVKGSGSSKRRRSTENQEVFDLDVIVNNEDDISHLNLNVCTSHLGSERTGMVLMEVNLLSGFSASSDSIPLSETLKKVEYDNGKLNLYLDSVNESQFCVNIPTVRDYKVSNIRDGSVSVMDYYEPRRQAVRSYNTQVKLSSCYLSPDTNCKSHTDGATDSLRRSSSLLVFCSVLLYFVQH
The following text describes a protein:
Function:
Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12. Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme. Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFLEDCIVTACQEGFICTWGRPGKVVSFNP
The following text describes a protein:
Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of xenobiotics that contain phenol functional groups. Acts in ASJ sensory neurons to modulate developmental arrest, perhaps by modifying endocrine signaling via the orphan nuclear receptor nhr-1.
Subcellular Localization:
Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
Sequence:
MTPKTPKTPKPPQTPRPMLTVGSPPCTPCSPFVLNATSFCFRKGPARSVVYQPNGHPKQVVIDGEIWPPIFKPKNVRTAKSMQFGETDVVIATYPKCGTTWLQHITSQLIKGHDYKAGKGNELCVQSPMIERMGAAFADNIKGPRVLKTHFHHYNIPKYPDTKYIYCVRNPKDCLTSYFHHNRNFKIYNWANGTWDVFLDLFASGQLAFGDYFEHLLSWLPCLKDDNVLFLKYEDMFQDLENAVYKIGQFLGGEAAHRVENPEILREIVDNSTIDAMKKDQKRWFPESQLHKVEFIRKGGSRDWKNYFTREQSDRIDSIFAAKFAGTPAEHWWKYEMAWEEKPLSIENLSMEEEEEEQSQKLFALPPLPPQRRFSRTSLLSAGYGSVWSLSSQNANMSASSSVNKDLSTFAE
The following text describes a protein:
Function:
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
Sequence:
MPIKSSDHSLYALFGGTFDPIHYGHLKPVEALAQQVGLQHIILLPNHVPPHRPQPEANAQQRLKMVELAVAGNPLFSVDSRELLRDSPSFTIETLEALRKERGAEQPLAFIIGQDSLLSLHKWHRWQALLDVCHLLVCARPGYSQSLETPELQQWLESHKVMDPQALSQRPHGAIYLADTPLLDISATDIRRRRHNGESCDDLLPQAVQRYIELQGLYRG
The following text describes a protein:
Function:
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MSRKLFKSTLVVSSMTLISRLLGFARDVVLAIIFGAGPAFDAFVVAFKIPNFMRRLFGEGAFAQAFVPVLSDYRANRKPEEVREFINHIAGSLGTALLIVVALAEILAPVIIMVFAPGFVRDPVRLAYATHMLRITSPYLFLIALTAFAGATLNTFNRFGVPAFTPVLLNVAMIAVAGLWALHASTPIYILAWGVLIGGILQLLIQVPFLYRLNLFPVPKWQWRDPGVMRVLKLMVPALFGVSVAQISLLMDNFFASFLAAGSISWLYYSDRLTYLPLGVIGVALATVVLPNLARQHSQKSAQAYSATLDWALRMAMLIGVPAAVALFILAGPLLATLIYHGAFTAHDVLMTRRSLWAFSVGLPGFMLVKILASAFYSRQNVKTPVKIATAAVVVNLTLNAVLIHPLAHAGLALATSLASSFNAVLLLYFLLRDKIYQPLPHWTKLILRLLFANGIMGLAIGAFAGRVDHWLMWSVMERVWHLVVVILLGLLSYAAAVWISGLRLRDLRPPVNID
The following text describes a protein:
Function:
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.
Subcellular Localization:
Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cytoplasm.
Sequence:
MSVQLFFLYLQTACFREERDVLVNGDCQWITTLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIHSIHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKRHAFFEGINWEDIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNPEIVPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSVMQSNAITKDEEVQRDLENSLQIEAYERRIRRLEQEKLELSRKLQESTQTVQSFHSSARSTGNSNRDKEIKRLNEEIERLKNKITDSNRLERRLEDAVTLRQEHEDSTHRLKALEKQLRVLRQEKEDMQKQMIEASERLKSQTKELKDAHQQRKLAMQEFSELNERMADLRSQKQKISRQLRDKEEEMEVIMQKIDSMRQEIRKSEKARKELESRLDDAIAEASKERKLREHSESFSKQVESELEALKIKQGIRGSGVTLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTVKDKYERERAMLFEENKKLTTETERLCSFVDKLTAQNRQLEDELQDLAAKKDSVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELESLRSSSLGSRTLDPLWKVRRSQKLDMSARLELQSALDAEIRAKQLIQEELRKVKETNLAFESKLKESEAKNRELLEEMENLRKKIEEKFKADTGLKLPDFQESIFEYFNTSPLPHDLTFRTSSTSDQETQVPKAEVSPSTTVSINTEQQEETTRPQQRGPAISSPTIQSLSLAVPKPKAHQFSVKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFSCHVSCKDSAPQVCPIPPEQSKRPLGVDVQRGIGTAYKGYVKIPKPTGVKKGWQRAYAIVCDCKLFLYDLPEGKSTQPGVVASQVIDLRDEEFSVSCVLASDVIHATRRDIPCIFRVTASLLGTPAKTSSLLILTENENEKRKWVGILEGLQSILHKNRLKNQVVHIPQEAYDSTLPLIKTMLTAAIVDRDRIAIGLEEGLYVIELTRDVIVRAADCKKVYQIELAPKEKIIILICGRNHHVHLYPWSSLDGSEGNFDIKLPETKGCQLIVAATLKKSSSTCLFVAVKRLILCYEIHRTKPFHKKFNEIVAPGSVQWMTVFKDRLCVGYPSGFYLLNIQGDGQSLNLVNPNDPSLMFLSQQSFDALCAVELTNEEYLLCFSHMGLYVDSQGRRSRMQELMWPATPVACSCNSSYITVYSEYGVDVFDVYTMEWVQTIGLRKIRPLNMEGTLNLLNWEPPRLIYFKNKFSGAVLSVPETSDNSKKQMLRTRSKKRFVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLSVLPSSQEEKAGPSSANLSRQPQSRSKTYVSWPSSGGGDLGVTIPLRSMSDPDQDFDKEPDSDSTKHSTPSNSSNPSGPPSPNSPHRNQLTLDGLDQSTCDA