lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate (By similarity).
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase.
Sequence:
MEEQPRERSEAGAEACEEKRGLSQAAEERIEDRISLLLRLRAQTKQQLLEYKSMIDTNEEKTPEQIMQEKQIEVKIEELENEIEDVKSNIEMKSLALSRMKLSVALRDNMENMGPENCVLTDDMKHILKLQKLIMKSQEESSELEKKLLDVRKKRLQLKQASRSKLLEIQIEKNKQKEDVDKMENSEMIKTMKKKLQTEIKITTVVQHTFQGLILASKTNWAEDPALRETVLQLEKDLNTL
The following text describes a protein:
Function:
Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen (By similarity).
Sequence:
MKMNRHFTVPQNGESSTIQWTKRNSKITNPDGSKVFEANDILVPEDWSQVAVDILAQKYFRRKGVPKYLKKVQEDGIPEWLQKSIPDTEKLESLKPEDRFGGETSALEVFHRLAGCWTYWGYKYKYFSDEESAKIFYDEIVYMLATQMAAPNSPQWFNTGLNWAYGIDGKSQGHYYVDPSTGKLVKSTSAYEHPQPHACFIQSVDDDLVNEGGIMDLWVREARLFKYGSGTGTNFSNLRGENEPLSGGGKSSGLMSFLKIGDRAAGAIKSGGTTRRAAKMVCLDVDHPDIENFIDWKVTEEKKVASLVTGSMLNNRHLNAIMSACYEMEGEDRFNPKKNSSLKKTIQDAKKVLIPDNYIKRVIDLARQGYKEILFEELTTDWQSDAYNTVSGQNSNNSIRLTNEFMAAVEQDQPWNLYFRTEKEKAKVEGRKAKPSQTLRARELWEKISYAAWASADPGTQYHTTINEWHTCPEDGPINASNPCSEYMFLDNTACNLASANLQKFVNLETLNFDVEGFRYLCKLWTIILEISVTMAQFPSKEIAELSYKFRTLGLGYANLGSVLMVLGIPYDSQQAMAITGAISSIMHMTAYATSAEMAKEQGPFVGYAKNQKHMLRVIRNHRRAAYNAPSGDYEGLTITPIGINPAFCPSYMLKAAQEDADLALSLGEKYGFRNAQVTVIAPTGTIGLVMDCDTTGIEPDFTLVKFKKLAGGGYFKIINQSVPYGLKKLGYSPSEIEAIVNYCKGHATLNGAPVINTQALKEKGFTNEILEKVEASLPLAFDINFAFNKFNLGENFLTKNLGISKEIFDSPGFSLLEHLGFTKEDINKANDYVCGTMTIENAPFLKEKDYPVFDCANKCGKYGKRFLSYESHIRIMAAAQPFISGAISKTINLPEEAVIEDIKNAYFLSWKMMIKANALYRDGSKLSQPLNSVLELLNGIEIDDQEEIREATISKDPVQIAEKIVTKYISHRRKLPSRRAGYTQKAIVGGHKVYLRTGEYEDGQIGEIFIDMHKEGAAFRSLMNAFAISVSLGLQHGVPLEEYVDAFTFFKFEPNGIVSGNKHIKMSTSVIDYIFRELAITYLGRYDLGQVAPEDLRGDEIGSKRATAESNGQEKETLSSMTAVIEPTPKKEVETISYSQMISKEKPSSSPSGISLLEEVKLAKIKGYTGDSCSECGSFEMVRNGSCLKCMSCGSTTGCS
The following text describes a protein:
Function:
Part of a type III secretion system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNDSELTQFVTQLLWIVLFTSMPVVLVASVVGVIVSLVQALTQIQDQTLQFMIKLLAIAITLMVSYPWLSGILLNYTRQIMLRIGEHG
The following text describes a protein:
Function:
Has a role in the initiation of DNA replication. Required at S-phase checkpoint. Required for the association of PSF1 with origins. Also required for the proper activation of RAD53 in response to DNA damage and replication blocks. Multicopy suppressor of DPB2 mutation. Overexpression restores the growth defect conferred by POL2 mutation.
Miscellaneous:
MISCELLANEOUS: Present with 540 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MKPFQGITFCPTAINNEILAKKISKKIIKLGGIFSKDLTRQVNVLVVGSTTNTNKFKFAVKHRFDIIFIDIQAIDDIYQLWLSGENILPDSNTATMTGSTYEMLKILYRRFSFKYLHNFNIFIGRITDTNITSIDSLVRSIKKLGCSSYNYQNFVIKDTSSHNDDDDQGQNGQISIFVTDTLLGARVNAAIEQNIPIVHFKWILDCQKRSALLPYDPYYLLPNIKDLPYDSIGSNSCDCWDKINTTFPTNIDAQSSLQRQQSSSTLTPSLPKTSSLLNKFKPKGEKIWDKAMSLQQHSKTNFSVLGQSPLSINNKQEDLSDNSTLIFKNCAFIIHHIFPGNHRSILTKIVVQNGGKIETSYLSGIYDHSYYIIPSNKALDSFNDLPEIIDDNDGIVTEFFIERCLYYQKLLHPIDLWSKPFLSTIEFQVSSSSKLLHHEFSSSPFLNVTITGFSGVELLHLTKVLNLLKPMGINYVEYLNKSTDILLINLAALPSIPKTHPLWSNEFSDLFTQFCINNNNDDPGDNNRKDFQNNSILRNSMKRKIEYIKKFHSIPVVTPAFIFKLLSAASGENNEIFLNNIKWCIICPRGHKDDFKCKIKKPYYTSISSEKKYQNNDPKIDKTILLKRNNSSLSEHSMKDTKNELLQKIRETDSGRKKRSVSSSIMDVSSERQMPDTKRIKLESLPKNFVPKQIKRTTSWGTIMSENVPTEQPTAISNPEEIPRTEEVSHTQVTYGSIQDKKRTASLEKPMRRQTRNQTKELDS
The following text describes a protein:
Function:
FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space (IMS) (By similarity).
Subcellular Localization:
Mitochondrion intermembrane space.
Sequence:
MVFGKRYRDKETGIIYDENGRPCKTCNIFSSFRNVAQQPNSSTVPEVKSNTQLESKQSSIDCNTNAIPDSVSFPRLPDVAELGRSTWTFLHAMAANFPKNPTPTQQNDMSSFLYNFSKFYPCWSCAEDLRIWMAKYGNSPRVDSRESLCEWICEAHNDVNERLGKPLFNCQVWSKKASELAD
The following text describes a protein:
Function:
Minus-end microtubule-dependent motor protein. Involved in apically targeted transport. Required for zonula adherens maintenance.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes along zonula adherens only at mature cell-cell contacts (By similarity). Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells.
Sequence:
MVPSRRTWNLGATPSLRGLWRVGRVQEPKPGMARPAPASPAARPFPHTGQGRLRTGRGKDILPSGEEDSTSRTAARPSLAQCRALSVDWPGPRSPHRLYLTVQVENLKEKLISQAQEVSRLRSELGGTDAEKHRDRLMVENEQLRQELRRCEVELQELRAQPVVPCEGCEHSQESSQLRDKLSQLQLEVAENKGMLSELNLEVQQKTDRLAEVELRLKDCLAEKAQEEERLSRRLRDSHETIASLRAQSPPVKYVIKTVEVESSKTKQALSESQTRNQHLQEQVAMQRQVLKEMEQQLQNSHQLTVQLRAQIAMYEAELERAHGQMLEEMQSLEEDKNRAIEEAFARAQVEMKAVHENLAGVRTNLLTLQPALRTLTNDYNGLKRQVRGFPLLLQEALRSVKAEIGQAIEEVNSNNQELLRKYRRELQLRKKCHNELVRLKGNIRVIARVRPVTKEDGEGPEATNAVTFDPDDDSIIHLLHKGKPVSFELDKVFSPWASQQDVFQEVQALITSCIDGFNVCIFAYGQTGAGKTYTMEGTPENPGINQRALQLLFSEVQEKASDWQYNITVSAAEIYNEVLRDLLGKEPQEKLEIRLCPDGSGQLYVPGLTEFQVQSVDDINKVFEFGYNNRTTEFTNLNEHSSRSHALLIVTVRGVDCSTGLRTTGKLNLVDLAGSERVGKSGAEGNRLREAQHINRSLSALGDVIAALRSRQGHVPFRNSKLTYLLQDSLSGDSKTLMVVQVSPVEKNTSETLYSLRFAERVRSVELGPGSRRTELGSWSSQEHLEWEPACQTPQPTARAHSAPGSGTSSRPGSIRRKLQPSA
The following text describes a protein:
Function:
Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity). Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate.
Subcellular Localization:
Cell membrane. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MRREFCWDAYSKAAGSRASSPLPRQDRDSFCHQMSFCLTELHLWSLKNTLHIADRDIGIYQYYDKKDPPATEHGNLEKKQKLAESRDYPWTLKNRRPEKLRDSLKELEELMQNSRCVLSKWKNKYVCQLLFGSGVLVSLSLSGPQLEKVVIDRSLVGKLISDTISDALLTDSFIILSFLAQNKLCFIQFTKKMESSDVNKRLEKLSALDYKIFYYEIPGPINKTTERHLAINCVHDRVVCWWPLVNDDAWPWAPISSEKDRANLLLLGYAQGRLEVLSSVRTEWDPLDVRFGTKQPYQVFTVEHSVSVDKEPMADSCIYECIRNKIQCVSVTRIPLKSKAISCCRNVTEDKLILGCEDSSLILYETHRRVTLLAQTELLPSLISCHPSGAILLVGSNQGELQIFDMALSPINIQLLAEDRLPRETLQFSKLFDASSSLVQMQWIAPQVVSQKGEGSDIYDLLFLRFERGPLGVLLFKLGVFTRGQLGLIDIIFQYIHCDEIYEAINILSSMNWDTLGHQCFISMSAIVNHLLRQKLTPEREAQLETSLGTFYAPTRPLLDSTILEYRDQISKYARRFFHHLLRYQRFEKAFLLAVDVGARDLFMDIHYLALDKGELALAEVARKRASDIDAESITSGVELLGPLDRGDMLNEAFIGLSLAPQGEDSFPDNLPPSCPTHRHILQQRILNGSSNRQIIDRRNELEKDICSGFLMTNTCNAEDGELREDGREQEIRDGGSLKMIHFGLV
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MYFSQEEWEILGPIQKDLYKDVMQETYGNMISVALFMIPKPELISCLEQEKEPCVTNSKESKEIPKDSNTEMTDSSICPNGINATIENEKPEEVYHIPLEIQASDDTLSEKTDGEVFKRTELKEVHENKCREEKPQHNFPVGKWKKYSPWKKSLRKLMETHKKAYTGEKPFKCHICGKSFKVSSDLIKHQRVHTEERPYRCQECDKRFRWSSDLNKHLMTHRGIKPHRCSWCGKSFSQNTNLLTHQRTHTGEKPFKCHECGKRFSQNSHLIKHQRTHTGEQPYTCSMCGRNFSRRSSLLRHQKLHREKETVSVLILKESSKWS
The following text describes a protein:
Function:
Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSGFSLPFPINSPLQAASIYSASYPFHRPVLPIPPVGLYATPVGYGMYHLS
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
Subcellular Localization:
Cytoplasm.
Domain:
The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.
Sequence:
MELSYYEILEVEKHSNQETIKKSYRKLALKYHPDRNAGDKEAEEKFKLINEAYGVLSDEKKRALYDRYGKKGLNQAGASQGDFSDFFEDLGSFFEDAFGFGARGSKRQKSSIAPDYLQTLELSFKEAVFGCKKTIKVQYQSVCESCDGTGAKDKALETCKQCNGQGQVFMRQGFMSFAQTCGACQGKGKIVKTPCQACKGKTYILKDEEIDAIIPEGIDDQNRMVLKNKGNEYEKGKRGDLYLEAQVKEDEHFKREGCDLFIKAPVFFTTIALGHTIKVPSLKGDELELKIPRNARDKQTFAFRNEGVKHPESSYRGSLIVELQVIYPKSLNKEQQELLEKLHASFGYEGEPHKSVLETCISKIKDWFK
The following text describes a protein:
Function:
Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHNLTLFESGGDNVSCGGSSLGCPNGSSLAPLPLPQPLAVAVPVVYGVICAVGLAGNSAVLYVLLRTPRMKTVTNVFILNLAIADELFTLVLPINIADFLLRRWPFGEVMCKLIVAVDQYNTFSSLYFLAVMSADRYLVVLATAESRRVSGRTYGAARAVSLAVWALVTLVVLPFAVFARLDEEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVTTICALYTTLLCRLRAIQLDSHAKALDRAKKRVTLLVAAILAVCLLCWTPYHLSTIVALTTDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRRSLRQLVSCRSA
The following text describes a protein:
Function:
May be responsible for elevation of the vitelline coat at the late developmental stage of oogenesis and during fertilization in ovarian eggs.
Subcellular Localization:
Secreted.
Sequence:
MIVTFVALALSCCTPQVTADCGLRPRLQSAIITGRIVGGEMAKLGEFPWQAAFLYKHVQVCGGTIIDTTWILSAAHCFDPHMYKLQSIKKEDALIRVADLDKTDDTDEGEMTFEVKDIIIHEQYNRQTFDNDIMLIEILGSITYGPTVQPACIPGANDAVADGTKCLISGWGDTQDHVHNRWPDKLQKAQVEVFARAQCLAAYPESTENMICAGLRTGGIDSCQGDSGGPLACPFTENTAQPTFFLQGIVSWGRGCALDGFPGVYTEVRKYSSWIANYTQHLLQDRNADVATFTITGDPCSSNGSIISGSEGDFSSPGFYSGSYTDNLDCKWIIQIPDIGSRIQLSFTEFGVEYHTFCWYDDVKVYSGAVGNIASADAADLLGSHCGMNIPSDLLSDGSSMTVIFHSDYMTHTLGFRAVFHAVSADVSQSGCGGIRELLTDHGEFSSKHYPNYYDADSICECFITAPTGKTIELNFLSFRLAGSDCADNVAIYDGLNSSYPRIIRLCINQGFNVTVPSSSNTMFVSFKTDGQVQDVGFEAYYYFSSNGNSTDDTDYSQCGFSSTPINADQTAARIVNGDIAIAGSWPWQISIRLCDTCNHYCGGSIISPSWIVTAAHCIESSAHITYIRAGDFDRFTIEISETIVPVAQIFIHPDYQKDLPNNADIALLKLANPLSYSSTIRPVCFPSQISTIPEENAECYVTGWGLTEENVMAQKLREAKLPLMPYDQCLNVYTSYVLNENMLCAGNISSGIDTCLGDSGGPFVCRKSRNDPWILYGVSAFGRECGSSRYPGVYTKVTRYIDWIIATANVSTVTSVVEEHDPTEFEQGCIQLLVLSNHEGDLSSPEYPELYGEGMLDCQWKIVLMDRTKSLNINFRFSHSQQDTAAACSLANIRISESYSDGTVGRQYGPYCGSSESILISSLHDLVVSLHNSQSQVKIGLKLEYRLEELEQSGCGQLKHLIENKGNFSSINYPNIYSANSHCEWYLHASIATHYLQISLSQFSLENAYQCRYDFLTVIDVTENGNISHGPYCGNSIPHVITGHGLFHIKFRSDASLNYKGFFASFVELNERPQEESGCGGVKFLNGTNGTFQTAGFPLAYEANLDCTWVIEVEDGYKVRLNFQQFSLESSSSCKYDWAMLYNGEFAFEAQRIDTLCGYDVKLEDIFESTSNVMRIDFHSDFSFNKQGFLAMYTAVSPGSSRSSVHQRENHLQEKRSGGCQDSIFTDEEGVIEYKQGDHTGNTRCLFRILTNHLHVIRLWLRKLSSLNLHENDSIKIYDKIDVDDIYSGVVKPVFQFTGIIGYLDSLPAYLDYNGGEISMLFSSDGQHGDTSFELIYKLMQDKSSTTNPKQLWNDHHGKWPWMVSLFGSSKYYFCSGVIISSRWIATAATCNLRSSEIHIIFPEGTNPKKIWEVEKIVVHPEFKMIYNVPQNDLALIQLVDPIEHIPPVCLPVASNIYSDCHVLKIPRLAGSAAFPDIVRISSVDTLAHDICMREWHLRITDDMLCGRINGTNSCQRDVGGPLVCQSPSDDAWYFVGISSWGPKICNDNTAHHRLPDVYVSVAYFLKWITKIIQ
The following text describes a protein:
Function:
Acts as an essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules.
Miscellaneous:
MISCELLANEOUS: Present with 1310 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore.
Sequence:
MSLEPTQTVSGTPPMLHQRTHKQVYPLRMETIPILESDSKATLQSNEPTQKDEEETEYFENKQSVSNLSPDLKFKRHKNKHIQGFPTLGERLDNLQDIKKAKRVENFNSSAPIADDNHSGDATANATANATANATANVNASAMPAPYMPYYYYYHPMNAPTPAMIPYPGSPMHSIMPNSSLQPFYSQPTAAGGPDMTTPQNISSSQQLLPAPQLFPYGSFHQQQLQQPHYIQRTRERKKSIGSQRGRRLSMLASQANGGSTIISPHKDIPEEDFYTVVGNASFGKNLQIRQLFNWCLMRSLHKLELKAKNQEEEGELEHLTKKSKLESTKAETDYVDPKRLAMVIIKEFVDDLKKDHIAIDWEDEEKYEDEDEEKILDNTENYDDTELRQLFQENDDDDDDDDEVDYSEIQRSRRKFSERRKALPKEPKKLLPNSKNVENTKNLSILTSKVNAIKNEVKEWAVTLDTSRPDLEWQELTSFSSQPLEPLSDTEEPDLAIADVETKLETKVDELRYQSHILNSHSLALNEITNSKVNKLNIETMRKISSETDDDHSQVINPQQLLKGLSLSFSKKLDL
The following text describes a protein:
Function:
Small subunit of the glutamine-dependent carbamoyl phosphate synthetase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, constituting the first step of 2 biosynthetic pathways, one leading to arginine and/or urea and the other to pyrimidine nucleotides. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.
Sequence:
MRNVTLILDDGSRFSGKSFGYEKPVAGEVVFNTAMTGYPESLTDPSYAGQLMTLTYPLVGNYGVPPFTIEPNGLATFMESEKIHAEAIIVSDYSSEYSHWNAVESLGDWLKREKVPGITGIDTRELTKILREHGVMMGRIVFDDEIVGEIDNGQLTMDNYAAVNYVDRVSCKEIISYLPDGTSQCFPLSTSIAQLNSQLLTFNSQLKKVVLVDCGVKTNIIRCLLRRGVEVIRVPWDYDFNGLEFDGLFISNGPGDPDTCDAAVQNIRKAMANEKLPIFGICMGNQLLSKAGGAKIYKLKYGHRSHNQPVRMVGTERCFITSQNHGYAVDNNTLGADWEPLFINMNDGSNEGIKHKKNPWFSAQFHPEAASGPTDTEFLFDEFVNLLK
The following text describes a protein:
Function:
Maintains the supply of reduced ferredoxin under non-photosynthetic conditions.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MALSTTPSQMSVALPTRIDGSSRSMIKVQSISFTDKSWGPPLLRLDSKSRSLGVKKRSTICMSLQQSSKSKVLVTPLELEDPKETPLNLFRPKEPYTATIVSVERIVGPQAPGETCHIVIDHDGNVPYWEGQSYGVIPPGENPKKPGAPHNVRLYSIASTRYGDSFDGKTASLCVRRAIYYDPETGKEDPSKAGVCSNFLCNAKPGDKVKITGPSGKVMLLPEDDPKATHIMIATGTGVAPYRGYLRRMFMENVPNFKFDGLAWLFLGVANSDSLLYDEEFAGYRKDYPENFRYDKALSREEKNKKGGKMYVQDKIEEYSDEIFKLLDNGAHIYFCGLKGMMPGIQDTLKRVAEERGESWEQKLTQLRKNKQWHVEVY
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNFFRSQTMGYYKLIIPRESAWNVMNELAELDCIHFVDYDPTLPMINRPFANYIKRCDDLLVKLSLIEHEMKKYQKRITYCKDVNFLIKNFKQLIKERSKASHTYLDEIENDIDKKHQQLIEQSTNMENLHERRNKLIEHKSVLLKGEALLGQSFFQPANYVAEGFVNLQGKELDDIKILQGSVKFNYLVGVINKEDQIRFKRIIFRITKGNAWMNTMDIESDQIVDTKNDDAKIIKSVFVVVYPGGGGSNVITNKLNKICESFQVAKYTFPENNMVFQEKLRQIETELVETRNLLEMTKNQVEAYLDDFQRIYQNSNCSQIEELKLFLVKEKYLYTQLNYLRVQGSVLYGSIWLPQGADIKVDQALREGLPTGQLQISPPEGTRPPPTFFETNEVTWGFQEIVNTYGMPRYKEINPGLFTVMTFPFLFGVMFADIGHGFCLLLLGIYLCVYNKEIKDMLQLSDIWLLMMGFWAFYNGWIYNDFMSVPINLFGSCYEPGTVDDPIHKDEQVWVQKDQSCVYPFGIDPVWMCVPNELTFMNSYKMKLAVIIGVIQMSFGIILKGINAIYFKNWIDFIFEFIPQLTFFICSFGWMDFLIIYKWFVNWTGKTDQAPSIITLMINMILAPGKPVDPPLWGDGQSEASTQTALLLIALFCIPIILLPKPLIINSQNKKHHAQSASNLTESMNKDLYQKINEDSEGTQEISEVHTEQSGGGGHHEEFGDIFVHQVIETIEFVLGSISNTASYLRLWALSLAHGQLAEVFFQMCLNGGISSGGFVGAIRLLIGYSIFSMATFGVLMMMDVMECFLHALRLHWVEFQSKFFKADGYAFEKCSYAKVMQDNAVPKEE
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.
Subcellular Localization:
Endomembrane system. Golgi apparatus.
Sequence:
MFERSLSALIKGLRSHRGKDEPKYVAQIMDEIRHEVRSGDLEVKAEAVLKLTYLQMLGYPFSGANFHMLETMASAKYHHKHIGYLAAAQCFAADTDVLILATNMIKKDLQSSQPLDVAIALNGLSHITTPDLATHLGPDVIRLLTHSRPMIRKKALLVLYALIIKSPNLLETGWDRLRDKLDDSDLGVVSAAVNVVCELARRDPRPFLPLSPQLFRLLTTSTNNWMLIKIIKLFGSLTPLEPRLVKKLVPPITTIISTTPAMSLLYECIHTIIIGGMLTQPGGEDLAHTCVEKLAAFLTDSDQNLKYIALLALVKILPSHPHLVAEHQDVIFESIEDPDLSIRLRALELVSGMAVSRNLESIVLQLLSHLEPPSSSSQTASGSLNGAAAALKASLASGGWAGSDADPSSSSLAAITSANNPTLSPSYRLEIVERILALGSYDTYANVVDFSWYLDTLVHLSMVTNLPDGNSIGSQIRDQLIDITARVRAIRPHATRVMVSLLSDGRLVPSYDWTRSDAGLVLTRPLSGAAGDDMREARKVLHACAWILGEYAYELGSPASQVIVQLLRPALFDVAVCDASTSAACVHGAVKLYAFWASALSTRWSQDGMKPQVEFDDLVDTTHEVAARFEAIQRMSLDAEVQERTVEYRQLFRLIQKDFESYQAGPCTKDAKAAESAGSHSKDDLGKHVQQSEKREPTHTSPPRSLDLLSPLFFNHALGPLGANAQSRVPAPIELDLNAWIVAPESYVVLDGIHLPSHLDADNDAPSTTDVVQAAPKSADKESKAQRDARLQAQRAQDPFYIVSASNAPRQTARHVDEEQDVDQIPIVRLDTLMGSVIRGAQNEHVSAPVLEQEEMPEPIARKSKKKSSLKVTHAQDADPEGAMKVVKVTKKKKPSNKSGASRVVID
The following text describes a protein:
Function:
Protects cells from HOCl (hypochlorite) stress but not peroxide or diamide stress. Decreases the intracellular load of reactive oxygen species by up-regulating genes involved in methionine and cysteine biosynthesis and down-regulating Fur-regulated genes involved in iron acquisition. Has also been suggested to down-regulate expression of the flagellar regulon, decreasing motility, but this activity was not confirmed in a second study.
Sequence:
MDDCGAILHNIETKWLYDFLTLEKCRNFSQAAVSRNVSQPAFSRRIRALEQAIGVELFNRQVTPLQLSEQGKIFHSQIRHLLQQLESNLAELRGGSDYAQRKIKIAAAHSLSLGLLPSIISQMPPLFTWAIEAIDVDEAVDKLREGQSDCIFSFHDEDLLEAPFDHIRLFESQLFPVCASDEHGEALFNLAQPHFPLLNYSRNSYMGRLINRTLTRHSELSFSTFFVSSMSELLKQVALDGCGIAWLPEYAIQQEIRSGKLVVLNRDELVIPIQAYAYRMNTRMNPVAERFWRELRELEIVLS
The following text describes a protein:
Function:
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
Sequence:
MKIGVIAIQGAVSEHVDALRRALAERGVEAEVVEIKHKGIVPECSGIVIPGGESTTLCRLLAREGIGEEIKEAAARGVPVLGTCAGLIVLAKEGDRQVEKTGQELLGIMDTRVNRNAFGRQRDSFEAELDVVILDSPFTGVFIRAPGIISCGPGVRVLSRLEDMIIAAEQGNVLALAFHPELTDDLRIHQYFLNKVLSC
The following text describes a protein:
Function:
Displays arylsulfatase activity at acidic pH towards artificial substrates, such as p-nitrocatechol sulfate and also, but with a lower activity towards p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.
Subcellular Localization:
Lysosome. Note=The 63-kDa precursor protein localizes to pre-lysosomal compartments and tightly associates with organelle membranes, most likely the endoplasmic reticulum. In contrast, proteolytically processed fragments of 34-, 18- and 10-kDa are found in lysosomal fractions and lose their membrane association.
Sequence:
MGWLFLKVLLAGVSFSGFLYPLVDFCISGKTRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTRNFAVTSVGGLPLNETTLAEVLQQAGYVTGIIGKWHLGHHGSYHPNFRGFDYYFGIPYSHDMGCTDTPGYNHPPCPACPQGDGPSRNLQRDCYTDVALPLYENLNIVEQPVNLSSLAQKYAEKATQFIQRASTSGRPFLLYVALAHMHVPLPVTQLPAAPRGRSLYGAGLWEMDSLVGQIKDKVDHTVKENTFLWFTGDNGPWAQKCELAGSVGPFTGFWQTRQGGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAQASLPQGRRFDGVDVSEVLFGRSQPGHRVLFHPNSGAAGEFGALQTVRLERYKAFYITGGARACDGSTGPELQHKFPLIFNLEDDTAEAVPLERGGAEYQAVLPEVRKVLADVLQDIANDNISSADYTQDPSVTPCCNPYQIACRCQAA
The following text describes a protein:
Function:
Involved in cell shape control.
Subcellular Localization:
Cytoplasm.
Sequence:
MQPLGSIYIEDTGNTDINRITPDRKNVEIFLKWRSFLLNILIIGNGQCGNRILDSINRHALGGGKSCGKLARFYSTQRFKSHVETLALNTAINDLKEMKFTKAKDRIHIEHLHGVGANRNVGKQVFEEKKEIIMRQIEDRGNFDMAFVITSASGGTGSSFTPLLVKEMKKRYNYPVYCLVVLPFREEGTLYLQNTAFSIQEIRQNGADGIILADNQYLKNIGGSIQEAYDGINDMIAERILFLLDALDSEMMMVTDLGDFQTVMSGGAGLATMGFFRADKEIPIKTAIQNSLSPSSLLFSTDVYEEASRAMIVIKGDRKYLSIDDISTEIEKLSGAVGHVFKGIIVRSGEYPQVLSVLTLETAREMENLYSVAVQAINQEKAKKQRVEEGSKMEKAFSQIEGMEPEY
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS13 is part of the integrator tail module and acts as a platform for the recruitment of transcription factors at promoters.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Nuclear location is required for recruitment of dynein motors to nuclear envelope at G2/M.
Domain:
The cleavage module binding motif (CMBM) mediates recruitment of transcription factors.
Sequence:
MKTFSESHKTVFVVDHCPYMSESCRQHVEFDMLTKNRTQGIIPLAPISKSLWTCAIEASMEYCRIMYDIFPFRKLVNFIVSDSGSRTLNSWNQEDQNLQELMAALAVIGPPNPRADPECCSILHGLVEAVESLCKITDYQHESRTELMENADRVANRGRIICITNAKSDSHVQMLEDCVNETIHEHNKLAAGSDHLMQIQKCHLVLIHTYPVGEDSLVSDRPKKELSNVLISEVHSVKAGRHLSTKLNQLVQLHFDLASTTITNIPMKEEQHANTSANYDVELLHHKEAHVEFNKSAGEGYNGSSSRENCLKETVTLKWCTPRTNSVELHYCTGAFRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKSGSKVISHMLSSHGGEIFLHVLSSSRSILEDPPSISEGCGGRVTDYRITDFGEFMRENRLMPFAEPRYCMDGGPEVPLERAKEQLERHTRYWPMIISQTTIFNMQAVVPLASVIVKESLSEEDVLNCQKTIYNLVDMERKNDPLPISTAGTRGKGPKRDEQYRIMWNELETLVRAHVRGSDRHQRVMDCLMACRSKPPEEEERKKRGRKREDKEEKAEKPPKENEHEKKWQESERVKSVLDREKEDLAEAEVIKDSPDSPEPPNKKPHIMVEDTGPAEKSKGPMSLLSLWSSRINTANSRKHQEFVGRLNSVNNKAELYQHLKEENGAEGVENGKGSRQ
The following text describes a protein:
Function:
Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Endomembrane system. Cytoplasm, perinuclear region. Note=Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma Hep-G2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized Hep-G2 cells, distributed to the perinuclear region.
Sequence:
MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEILFGGLVWILVASSNVPLPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLEAAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP