lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MVRLWCSSLLMTILFQQLIRLCISWSVQTPTPPLPILPLPTYSQLQWQQREIIMFLHFGVNTFTDREWGTGQENPAIFNPTGLNTTQWATVAADAGVSLMILTAKHHDGFCLWPSKYTDHSVISSPWQGGKGDVVQDFVNAATAQGIDVGIYLSPWDRHDPRYGNDLLYNQYYLAQLQELLKKYSNVREIWFDGAKGANAKNMTYYFSDWFSMVKELQSSINIFSDAGPDVRWVGDETGSAGYTCWSTINRTSLSIGSPDIIQYINTGDPKGTDWLPAECDVSIRHGWFWHKSESPKKLSELLDIYYNSVGRNCVLLLNVPPNTSGLITEADANRLKEFRSAINTIFHQNLAEDCFVKVSSQRRGFGPEKMLDSEHLWSYWAPRDDDGEKDHWIEIWAKEGKFRFNVIRIQEAIGLGQRIKRHEIYVDGKLIIKATTVGYKRLHRLNGGEVHARVVRIRIRKARGVPLISSIGLHYDPFWHSKFTPT
The following text describes a protein:
Function:
Component of the transcription regulatory complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. The SAGA complex predominantly acetylates histone H3. Required for oogenesis; involved in transcriptional activation.
Subcellular Localization:
Nucleus. Chromosome. Note=As part of the SAGA complex associates with chromosomes near the transcriptional start site, matching the distribution of RNA polymerase II.
Sequence:
MNYNAKRVMRQNSVCVGSNDMAASPIMIGPAPPSAPSTPQLQTTEDIKPLLVQRQVILLQSGSIPTNPSPQQINLAGHNVAGGASGSNVANVLIPDDAPVSLLTEIADIMRSFGDSDQPRTGSVKLVEQILQQQLRGIFNEASLVAMRRKQNPCPSQADFEFLMRNHPVKIARMRKHLKDMRILKRFLSIRTGRPQDFMDDLEQQEEDEELAIDVYELHDEDRMRRLFRADRISQILTGQQYLEFNEARKTSFYCRHGEKIKNKFRRFLDLPADLRIPTPTMNILAYLAHETIAAIVDYSILTRLNSDNRATEPYSRVTSAGGSPAMMHVCPEVTQGRGMEVVKPISVPEIHEAMRRFRQMSSRKIGRYRNSCDIDFRRSFLAI
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MERIPLSVFEKFNNQELLSDVPEDRFISKSLQSPEIFSTPCEECTYFTKSNNNNILKFDDTTGLNTVLVSYTQQSKKRKQKKTNASSKGRPKIIGSDLTQGFSDFKPESLKDIYSLNDIFKSIQYLIQNKNFTPQDFKIVTARRHLQKLMTIPIHKQEVQFNVIYWKGMIFFAYDWKSESTTKVEDPYNKLIQYTGFKFEEVVSEGTRDSNFYTVVQHCVDNIPVIYTAEVDCSIDKETGLENYIELKTHTKLADDKISTINKLNKKLLSTFIQTKFIDCQHSIIGFRSTDLKIASIKKYTQRELAGEINSFPVILSDKCSINTKSIFQWYKLIMNWIISKEITDHNTPQIFRLSFKRDQELMNSYLKLEKILQEDDNDTIFNDLVPEWFQSFIMNLF
The following text describes a protein:
Function:
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKNAPKSFEEALSRLESLTQSMQGEMPLEDALAAYQEGNELVRYCQTKLAQVEQKLQVLDTDGLKELNLESDE
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Sequence:
MSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEEGIGLAATQVDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGNPFELEADGLLAICIQHEMDHLVGKLFIDYLSPLKQQRIRQKVEKLDRLNARA
The following text describes a protein:
Function:
Catalytic subunit of the THUMPD3-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 6 (m2G6) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases. Also catalyzes the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 7 of tRNA(Trp).
Subcellular Localization:
Cytoplasm.
Sequence:
MSCDTQEATRECLGMNLDGNKEPVSLVESGVRSESEHLQVTIGATVPTGFEQTAAGEVREKLKSACRISKDRGKIYFDIAVESLAQVHCLRSVDNLFVVVQEFKDYQFKDTKEEVLRDFEELAGKLPWSDPLKVWQINTTFKKKKAKRRKANQSAGKEKADCGQGDKADEKDGKKKHASSTSDSHILDYYENPAIKEEISTLVGDVLSSCKDETGQSLREETEPQVQKFRVTCNRAGEKHCFTSNEAARDFGGAIQEYFKWKADMTNFDVEVLLNIHDNEVIVAIALTEESLHRRNITHFGPTTLRSTLAYGMLRLCEPKPTDVIVDPMCGTGAIPIEGATEWSHCYHIAGDNNPLAVNRAANNISSLLTKSQIKDGKTTWGLPIDAVQWDICNLPLRTASVDIIVTDMPFGKRMGSKKRNWNLYPACLREMSRVCRPGTGRAVLLTQDKKCFTKALSGMGHVWRKVHVVWVNIGGLHAAVYLLKRTAQAFVHPSDQDEGRDPPW
The following text describes a protein:
Function:
Sphingomyelin phosphodiesterase (sphingomyelinase) that converts sphingomyelin (N-acyl-sphingoid-1-phosphocholine) to ceramide (N-acyl-sphingoid base) and phosphocholine at acidic pH. Displays its enzymatic activity when secreted. May play distinct roles in signaling.
Miscellaneous:
MISCELLANEOUS: Requires Zn(2+) to be fully active; MISCELLANEOUS: There are two types of sphingomyelinases: asm (acid), and nsm (neutral). Only acid sphingomyelinases have been found in worms.
Subcellular Localization:
Secreted. Note=Only the secreted form is enzymatically active.
Sequence:
MQQPLIILGIGIVLALVSNVESGVLRKPVDEHEYEKWTNARGNEAAVPPPKYKMLRYAKKAINEPENRKMSCLFCTFAVDGVQALIAQNSTDNEIAAFLVNLCDLFDVEQPHVCKNIIYAFKDEVVFVLERSVFTPEEICGAFIANCGHSDKPLTHMWNITIPGGKPPIKPWPKIPDNKPTFKVLHLSDIHIDHQYVVGTEAYCQLDSALGTYAMCCRDYSQDSQGAPTNLKDKPIYVPAGPWGMPYLCDLPYQTFESAMKHISKTFKDLDYIIITGDFEAHDSWDYTEDLTRENMNNMTNVFLEYFPGVPVYVSIGNHEGVPQDAMAPHTMPEYDTRGPQWLYKIMSEMWSHWIPQEALDTVQYRASYAVYPKPGLKLISLNTIYCSEFNFYLYVNEVDPDATLEWLIEELQDSENKGELVHIISHIPPGDNYCLKGWSWNFFEIVKRYENTIAQMFYGHTHYDQFMVYYDMDDPNRRPFHFNWISPSLTTYDWLNPAYRIYEIDGGYEGATYTVKDAKTYFANVTEANMKNKEPEWVLSYDTREHYQMADFSPQSWSDLSDKLWTNTTLFRDYVRLYYRNHYNNECYTDYKCRYTFVCDIKKGRSYDESFCDHLTK
The following text describes a protein:
Function:
NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro).
Subcellular Localization:
Microsome membrane; Peripheral membrane protein; Lumenal side. Early endosome membrane; Peripheral membrane protein; Lumenal side.
Sequence:
MWFYLVTLVGLYHLLRWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDRRGMRVLAACLTEKGAEELRNKTSDRLETVILDVTKTESIVAATQWVKERVGDRGLWGLVNNAGVLQPFAYIEWYRPEDYMPIFQVNLIGLTQVTISMLFLVKKARGRIVNVSSALGRVALFGGFYSCSKYGVEAFSDVLRHEVQDFGVKVSIIEPGSFKTEMTDAELTIERTKKVWEAAPEHIKESYGQQFFDDFCSTTKRELMKCSRNLSLVTDCMEHALTSTHPRTRYSAGWDAKFFFIPLSYLPASLVDYLLAISRGKPAQAA
The following text describes a protein:
Function:
Sugar transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSFRDDNTEEGRNDLRRPFLHTGSWYRMGSRQSSMLESSQVIRDSSISVLACVLIVALGPIQFGFTCGYSSPTQAAITKDLGLTVSEYSVFGSLSNVGAMVGAIASGQIAEYVGRKGSLMIAAIPNIIGWLSISFAKDTSFLYMGRLLEGFGVGIISYTVPVYIAEIAPQTMRGALGSVNQLSVTIGIMLAYLLGLFVPWRILAVLGVLPCTLLIPGLFFIPESPRWLAKMGLTDDFETSLQVLRGFETDITVEVNEIKRSVASSSKRSAVRFVDLKRRRYYFPLMVGIGLLALQQLGGINGVLFYSSTIFESAGVTSSNVATFGVGVVQVVATGIATWLVDKAGRRLLLMISSIGMTISLVIVAVAFYLKEFVSPDSNMYNILSMVSVVGVVAMVISCSLGMGPIPWLIMSEILPVNIKGLAGSIATLLNWFVSWLVTMTANMLLAWSSGGTFTLYALVCGFTVVFVSLWVPETKGKTLEEIQALFR
The following text describes a protein:
Function:
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MGKEKPSSTEVLTPQLLIMKRLILTLFTLLLLRDLVISGGADSRKIIITQIINFNFEKTRINWTVTDNSARENLTFQYTLDGGSTWHLCPDYLFELGYKVGCLFQAEDETLEYSIHSGDELLYEQTLMTSSYIKPDSPKNLTFTWKESTVRIKCPNLNLGDLSYEIQYRSVFDDGWQSQEEEDCDIEAQGLDLEKCYTFRARVRAQEFGYGPDTYPSDWTPESLWRNGKSVDSCSVSPPARKILYLMSGLVTLVVTFLLLLLALWKSPRVKELIVPIIPDPKYIFPGLFDDHRGNFQEWIKETEDLMNPIDAECVEEPCVIEEELTVRPRRKENMVRDASRFQELPPSSEPAKDSHLSPPATDTVTFGNPKFVINENMYVVL
The following text describes a protein:
Function:
Cell surface proteoglycan which regulates dendritic arbor morphogenesis.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MRRAWILLTWVLVACVSAESRAELTSDKDMYLDNNSIEEASGVYPIDDDDYASASGSGAGEDGESPELTTSRPIPKIPFTSTAPRVETTTLSKIQDKIPAQTKSPEEIDKEKVHLPDSERKTDPAEEDTNVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis (By similarity). Required for sperm flagella assembly (By similarity). May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Note=Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme.
Sequence:
MMMSRKNVTYRQREKLIAEAQRQEFLREDRIKHLNYEQQMAESLKSEERVEKKRFLQRLQNEEHEKRMDEAIQLGEESRRLKERQLEQEERMALEMARIKHEKLKDEKIRQQIRENSTELRELEQKLKAAYLNRERAAQIAEKEVLKYEQMKEDLETVRKMQKDQERAEDEEIVRETKRYQEKLNYQIELERQLEEKEKTRQEAYHEFLKEKILIDEIVRKIYEEDQMETQLKLEKMNATRRYIEEFKEQQQTWRNMEQTRMEEENRKILAFANMQQRREEDRMAEVREREQQKKALQEKLAEQIQKEQQQREELEQMREELYLEEQAEEARQKAISEMEKKIRQRLEMQQTFEEQMAFKQIVQQAAKEEEEAFVQAMLAKFAEDDRIEQMNAQKRRMKQLEHKRAVEKLLEERRQQFIADKERELQERQEEERRESFRRAIIEEERQKILKQHATQLLGYLPKGIFKGEDDLNLFDEGFRQDFQKRRADISSNDGWD
The following text describes a protein:
Function:
Plays pivotal roles in chloroplast development. Is essential for the regulation of chloroplast development and differentiation.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MSAAALSLLPSSSPHLLFPPSSSSSSSSSSFVLGGTHLRTHKSFASLHSWSPSSSSSTTSSWKFNTKRRVGIVFAASGDYYATLGVPKSASSKEIKTAYRRLARQYHPDVNKQPGATEKFKEISAAYEVLSDDKKRALYDQYGEAGVKSTVGGSSSAYTTNPFDLFETFFGPSMGGFGGMDAGFGTRRRSTVTKGEDIRYDITLEFSEAIFGVEKEFELSHLETCEVCTGTGGKIGSKMRICSTCGGRGQVMRTEQTPFGLFSQVSVCPNCGGDGEVISEYCRKCSGEGRVRVKKNIKVKVPPGVSTGSILRVAREGDAGPRGGPPGDLYVYLDVEEIEGIQRDGINLSSTVSICYLDAILGAVVKVNTVEGIATLQIPPGTQPGDILVLAKKGAPKLNKPSIRGDHIFTIKVTIPNRISATERELLEELALLNNTTTRRSRTRPKVQPATDNIEPEVGMVGEKRDEGEDQNDPWKKLKDFAGSVANGALKWLRDNL
The following text describes a protein:
Function:
Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/eng.
Subcellular Localization:
Secreted.
Sequence:
MWRVGHLLLLMSIVFRITEEKSLGDAGSLEDSMFIQEQKLVEDDDLNKVESFLGFMKEDFLRKLNLSGVPQEHRKVQPPQFMIELYNRYASDKNSIPRSDVIRSFVVQDVIYSIRQGNKTQHRLLFNVSIPNHEEITSVQLRLFTLWHRHKPACDDLFTSINVYDVEYEQNAKILHLLDGRDVRESINTWEAFDVTGAVRIWHESRRGAGEIQVEVQHSCDSFDISLSLEDNSSAVVIVFSDDLGNRKEESMRKVKEMLVREQQQVGNQAPVSNRHRRRKRKAKNNYCRRTSLKVNFKDIGWDKWIVAPPEYDAYECKGVCYFPLTDDVSPSRHAVIQTLVNLSNPKKANMACCVPTKLDPIAVMYQEKGVITVRHLYEEMKVAKCGCR
The following text describes a protein:
Function:
Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle. Early endosome membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Sequence:
KMTHLQAGLSPETLEKAKVELKENPDTLHQDIQEVRDMIITRPDIGFLRTDDGFILRFLRARKFNHFEAFRLLAQYFEYRQQNLDMFKNFKATDPGIKQALKDGFPGVLSNLDRYGRKIMVLFAANWDQSRYTFVDILRAILLSLEAMIEDPELQVNGFVLIIDWSNFTFKQASKLTPSMLRLAIEGLQDSFPARFGGIHFVNQPWYIHALYTVIRPFLKDKTRKRIFMHGNNLNSLHQLIHPEILPSEFGGMLPPYDMGTWARTLLDHEYDEETEYSPESYSLSVKDLEKDLSPKAMKRSQSVVEPGVLKRPDKEKSEEDNMQPLLSLD
The following text describes a protein:
Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Tightly associated with the plasma membrane.
Domain:
This protein differs from the typical myosin heavy chain structure in having head and tail domains but no discernible neck domain.
Sequence:
MAVTNEEIKTASKIVRRVSNVEAFDKSGSVFKGYQIWTDISPTIENDPNIMFVKCVVQQGSKKEKLTVVQIDPPGTGTPYDIDPTHAWNCNSQVDPMSFGDIGLLNHTNIPCVLDFLKHRYLKNQIYTTAVPLIVAINPYKDLGNTTNEWIRRYRDTADHTKLPPHVFTCAREALSNLHGVNKSQTIIVSGESGAGKTEATKQIMRYFASSKSGNMDLRIQTAIMAANPVLEAFGNAKTIRNNNSSRFGRFMQLVISHEGGIRYGSVVAFLLEKSRIITQDDNERSYHIFYQFLKGANSTMKSKFGLKGVTEYKLLNPNSTEVSGVDDVKDFEEVIESLKNMELSESDIEVIFSIVAGILTLGNVRLIEKQEAGLSDAAAIMDEDMGVFNKACELMYLDPELIKREILIKVTVAGGTKIEGRWNKNDAEVLKSSLCKAMYEKLFLWIIRHLNSRIEPEGGFKTFMGMLDIFGFEVFKNNSLEQLFINITNEMLQKNFVDIVFERESKLYKDEGISTAELKYTSNKEVINVLCEKGKSVLSYLEDQCLAPGGTDEKFVSSCATNLKENNKFTPAKVASNKNFIIQHTIGPIQYCAESFLLKNKDVLRGDLVEVIKDSPNPIVQQLFEGQVIEKGKIAKGSLIGSQFLNQLTSLMNLINSTEPHFIRCIKPNENKKPLEWCEPKILIQLHALSILEALVLRQLGYSYRRTFEEFLYQYKFVDIAAAEDSSVENQNKCVNILKLSGLSESMYKIGKSMVFLKQEGAKILTKIQREKLVEWENCVSVIEAAILKHKYKQKVNKNIPSLLRVQAHIRKKMVAQ
The following text describes a protein:
Function:
Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.
Miscellaneous:
MISCELLANEOUS: Access to the profilin-binding site is masked in the full-length protein.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Localized to stress fibers and bundles of actin filaments.
Sequence:
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQGGVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPPPPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTNESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAAPPPPPPVIRNGARDAPPPPPPYRMHGSEPPSRGKPPPPPSRTPAGPPPPPPPPLRNGHRDSITTVRSFLDDFESKYSFHPVEDFPAPEEYKHFQRIYPSKTNRAARGAPPLPPILR
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA); A component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity. Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target. This leads to the formation of an R-loop in which the crRNA binds the target DNA, displacing the noncomplementary strand. Cas3 is recruited to Cascade, nicks target DNA and then unwinds and cleaves the target, leading to DNA degradation and invader neutralization.
Sequence:
MADEIDAMALYRAWQQLDNGSCAQIRRVSEPDELRDIPAFYRLVQPFGWENPRHQQALLRMVFCLSAGKNVIRHQDKKSEQTTGISLGRALANSGRINERRIFQLIRADRTADMVQLRRLLTHAEPVLDWPLMARMLTWWGKRERQQLLEDFVLTTNKNA
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MNRSIIPLLCSFLLLSASSASAFNITKILSQYPDYTNFNDLISKTGLASEINAKSTITLLAIPNGAIGDLTSKSNDVVKKILTTHVVLDYYDTMKLQKLKDKTTKLTTMFQESGKASNDQGFLNVTAKDNTFVFGSAVKDAQRDSRLEKSVMNQPYNISILGISQPIVTPGIDSPLAPSSAPPPKANTPKSSPPKAESPAEEEAEAPTKEDETEAPAPSKDADSPSADSPPADAQSPSSSAAEKLKISFGFFVVLASMVAAY
The following text describes a protein:
Function:
Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network.
Sequence:
MSGHDSKYFSTTKKGEIPELKEELNSQYKDKRKDAVKKVIAAMTVGKDVSSLFTDVVNCMQTENLELKKLVYLYLINYAKSQPDLAILAVNTFVKDSQDPNPLIRALAVRTMGCIRVDKITEYLCDPLERCLKDDDPYVRKTASICVAKLYDINAELVEDRGFLDTLKDLISDNNPMVVANAVAALAEIQENSKMPIFEITNNTLSKLLAALNECTEWGQVFILDALSKYKAEDAREAENIVERVTPRLQHANCAVVLSAVKMILQQMELITSTDMIRNLCKKMAPPLVTLLSAESEIQYVALRNINLIVQKRPTILAHEIKVFFCKYNDPIYVKMEKLEIMIKLASDRNIDQVLLEFKEYATEVDVDFVRKAVRAIGRCAIKLERAAERCISVLLELIKIKVNYVVQEAIIVIKDIFRRYPNTYESIIATLCESLDTLDEPEAKASMIWIIGEYAERIDNADELLESFLESFPEEPALVQLQLLTATVKLFLKKPTEGPQQMIQVVLNNATVETDNPDLRDRAYIYWRLLSTDPEAAKDVVLAEKPVISDDCDQLDSSLLNDLLANIATISSVYHKRPDAFVSRVKASVPKPDSDDITEGSEAGYSESPSHVTEATPVPGSSSLSSGTQPALVPDLLGDLIGLDNAIVPVDQTSPPSGPPLPVLLPSSSGQGLQISAQLTRRDGQIFYNILFENNSDNSLDGFMIQFNKNTFGIAAAGPLQVSQLQPGSSTTTLLLMVISQNLSAGPPSSVLQVAVKNNQQPVWYFQDKIPLHVFFLEDGRMERGVFLETWKSLPDANEITKDLPSAIVRNLDATIDHLASSNIFFIAKRKNANKDLLYLSAKTPKNTIFLVELTVLVGTPGIRCAIKTPSPEMALLFFETMETLLN
The following text describes a protein:
Function:
Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity).
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MDFSSKSLELCKSHSNQTDQLLKISKQTYEKYDNSLSKLHLIIRELNKQLIILKETSTQFNDRYNTFINDFTSLSNQKQSLFTSIENKLEILKKKYLDKGLVFKNNNNNNNNNNNNNNNNNNNSNKSTEDDNNENNNNNDVNKNNNNNNNNNLNTLYDFIDIESLELIKNQFLSELSGLNEICDKSKQIYKSTNESNLEMENRFLEIQKQYNKQIEESNSLSDLLTQQNNLYKTIQNQLINVASQCDFITFYKPSPSPLSPSPSPSSSSSSSSPSPSSPQQQHDFNINNKKEQIQLLLTSSLENIQLMSKNVKDIENQFKESCSIYTLVYLLNEKLSFGNDFSENWETFERFNCIFEQRLAGANYFIGELYSLGKWYDLFDESYDNLLEEVKRRQKEYLRQKTIAEQFNEELKHNYNQEIQNRLKFYDSYGKYLPVSLFSTISDQPISFQVKQIIEESVIDYSFNPLNLKRSSPINQQQQQQQPPPNS
The following text describes a protein:
Function:
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells (By similarity).
Sequence:
MLVSRFASRFRKDSSTEMVRTNLAHRKSLSQKENRHRVYERNRHFGLKDVNIPLEGRELGNIHETSQDLSPEKASSKTRSVKMVLSDQRKQLLQKYKEEKQLQKLKEQREKAKRGVFKVGLYRPAAPGFLVTDQRGAKAEPEKAFPHTGRITRSKTKEYMEQTKIGSRNVPKATQSDQRQTSEKQPLDRERKVMQPVLFTSGKGTESAATQRAKLMARTVSSTTRKPVTRATNEKGSERMRPSGGRPAKKPEGKPDKVIPSKVERDEKHLDSQTRETSEMGPLGVFREVESLPATAPAQGKERKSFAPKHCVFQPPCGLKSYQVAPLSPRSANAFLTPNCDWNQLRPEVFSTTTQDKANEILVQQGLESLTDRSKEHVLNQKGASTSDSNHASVKGVPCSEGSEGQTSQPPHDVPYFRKILQSETDRLTSHCLEWEGKLDLDISDEAKGLIRTTVGQTRLLIKERFRQFEGLVDNCEYKRGEKETTCTDLDGFWDMVSFQVDDVNQKFNNLIKLEASGWKDSNNPSKKVLRKKIVPGRTSKAKQDDDGRAAARSRLAAIKNAMKGRPQQEVQAHAAAPETTKEVDKIVFDAGFFRIESPVKSFSVLSSERRSQRFGTPLSASKVVPEGRAAGDLLRQKMPLKKPDPQSSKSEHVDRTFSDGLESRCHVEDTPCPGEQDSSDIEHDVNKINVKMDCFSVETNLPLPAGDANTNQKEAISAVEGASTAVTSQDLLMSNPETNTSSQSNTSQEEAEASQSVLLHKSLTSECHLLEPPGLSCTSPCTREETRQPDRSRQFSFGGDLILFSPL
The following text describes a protein:
Function:
Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.
Sequence:
MVDTQPYIIRVMEEMGLAEGGFIPIANEENKQLLEQINRLSAGRTDSAGKVQISDQRLGNLKVHLKNAQLEFEQNSKLIGVDKGQITTEHGLLKVSQNDRSFYRQQLSDAKKEHSELEKHDERAQGDMKKLTGNVEKYTERIKWAKGALAEWKQVMGDGDKTNKLILKYCKQDASKAESLEAKRKQLENKIATRRAVLVTLYEEYKSLEQVLERTSQLFRQAHYERRHMVQTWKEAVKHMNQREGAIKSVEADIDSAHEVTEMLQGDLQAQVEFLEQQQRNNQEIELRIADLNVEVSKLRNRLTALNDSVQLKTNEYQITRKAVQNLSNKLATMRSRNCHSLVEGNEKEQQIHSNLSELELLRDKLDNFRSKSLCAQDRLRQLNEIVESEEKQIRAMENETERLSTALFRAQQQLFAMREEDKLLKVEVHSTESGMAKIQAALKNMKKEIVRQLEISYTVDYNMEKVQERIANMKGAGNTQEEANRAHAKLTHAQNILMMKRQNLEVLLAQTVKIQQDYRQSSLVFQQDAAEIERMTGKWKEKTLLVEGGEKKVRQCKAENQERLVEKSLLKMRIKQMERQLDCQSDKMYTLERHRMELEAAINKRMVDITAQKDMLQLKRKYLAEERAQLRADISERSLKIEQLRNRYDLSLDLLGKNEDGTIVTATQIKIQTAQEKYMLLREGSELNVKILKAEEDLKALENTLKVMNYANDKYKRGFQKVEDENPDMIAMENIQADYCKAVAALKSVRSDLASNTENLHDLNECREQNDKALEQAQKVRLDSNDVLLRIQKELLDQRTKIQRAERELKLAIKAAKAKTNDDDLMLIFQKDLNLKELEERNSNALQHLADLVEQNTELAASVSKHCYERGLRLPLIKRTKSQISWRSENSHGTEYSGRVDTISSKQASRLSICTTTSSRNTDSSEDIAKSFDNRMSAGLSVILIDFPGSKAAGGKSTKK
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Sequence:
MASSPMDESQTASTSTSQSVGSLVNFLTLIQSLKTTKRTGWINHGVAGPESIADHMYRMAMMAFMIDPKDAAVDRDRCIRMAIVHDVAEALVGDITPDDGISKEEKNRREAAAMEHMCLLLGETPQAQEMRDLWLEYDAASTLEAKLVKDFDKLEMILQAQEYEASQGKVLDDFFVAAGRIQTDIGKKLADEIVVRRPNKR
The following text describes a protein:
Function:
This protein catalyzes the committed step to the synthesis of the acidic phospholipids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNVPNLLSLSRLILSPLILYFVLEENYLSSLVLVLFLALMDFLDGFFARKLNQSTRMGKILDPLADKVFTFFSLLSYTFFSKERLNPLIFFLLLGRDITLIIGGIFLIKRKFTPEPSIYGKFTTLFVSLSLLSVGILNVYDVNFLRILTNVLEIVSLILILVSWVDYTLKGFKMIFKE
The following text describes a protein:
Function:
Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
Sequence:
MELHYFVAITLPNHIKEMLSNYKEDMQEELQFRSWVHKEDYHITLSFLGSATGEQLEGIKNGLKTIAETKELSFTLQGFSTFGREDQPRIFWAKVSENHDLFQLQKQIHAICEENGFSLETRPYHPHITVARKWIGEEKFRLESIKEVPEISFQADTITLYESHVKETPKYKSIAEIKLQK
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MGRGRGSSTNMGLAQLSVLWLLSWQFQGLMIGVTSQVLSTTFYDFTCPVAEQLVQNTVQQAFLLDNTITAAIIRLLFHDCFVNGCDASIMLAGLNSEQVAVPNLTVRGYDVINNAKVQIEAVCPGIVSCSDIIVLAARDSVGLLGGPTYDVALGRLDGLGPGNVVLPTPSDTVATSIGQFLFNGLTVADMVVLLGAHSVGQSQCQFFNNRLYNFNNSGFPDPSLNATFLATLQGLCPQNGSGNANVPLDDQTEFVLDTDYYRTILDGRGLLTIDQDLVADAGTRNVVDNLAGRASDLNLTFSSAFVAAMDKMSRIGLKTLIDGQVRRVCSAVN