lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play a role in late hair differentiation.
Miscellaneous:
MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).
Sequence:
MDTKGSTVTISSSTPPQNCSGNTNVRTNSSNKSCYHDVQSTGHALQTPQGQGCRPSPCLYRCPNYLIRTYSFHPCPDDCSRCSDGINSHEKETMQILNERLASYLEKVRMLEGENADLEDKIQEECSKTLPILCPDYLSYYTTIEQLQQKILCTKAENSRLVSQIDNTKLAADDLRAKYEAELSLRQLVEADANGLKQILDALTLSKADLEARVQSLTEELLCLKTNHEEEINSLQCQLGDRINIEVTAAPSVDLNQILQKMRCQYESIVETNRKDVEEWFNTQMEELNQQVVSSSQQQQCCQKDIIELRRTISALEVELQAQHRMRDSQECILAETEARYTALLAQIQSLIHNLEAQVAEIRSALQRQNQEYEVLLDIKSRLECEIATYRSLLESLDGRLPCNPCTTTWEPSCQARAMECLTPVYTSISLPGIHKPCRASGPPSRILVKICTITKEIKDGKVISSHEHVQPCYITRPAKV
The following text describes a protein:
Function:
May play a role in the cytoplasmic assembly of the ciliary dynein arms. May play a role in fertilization. Binds GTP and has GTPase activity.
Subcellular Localization:
Dynein axonemal particle.
Sequence:
MTAKDYPSFWGFGTTKMFKIPVEHLDFKYIEKCSDVKHLEKIFCVLRSGEEGYYPELTEFCEKRLKGLAPESRALRKDKPPATASSFTAEEWRHIDSDIKSWVSEIKKEDEVYFHETETFPAMEDNLPPVRGSNSRLHVSKEKYSNSRPTKKKIPRDYAEWDKFDVEKECSKIDEDYKEKTVVNNKSYLSKIETRIGTAGLTEKEKTCLATREKEKGNEAFNSGDYEEAVMYYTRSISVLPTVVAYNNRAQAELKLQNWNSAFWDCEKVLELEPGNIKALLRRATTYKHQNKLQEALEDLNKVLNVEPDNELAKKTLLEVERDMKNSEPASKTQTKGTRMVIQEVENSEDEGGKDSGRTHKDGSGVKKAAEPAAAGSPAAPSAMGNIQKKLTGEGEGGGKRPERGAPRRGRGPGAGADKRGRARAAEAEAAGSAYRHPGGGRGAGDPAGLKSQGNELFKSGQFAEAALKYSAAIARLEPAGSGSADDLSVLYANRAACYLKEGNCGGCIQDCNRALELHPFSVKPLLRRAMAYETLEQYQKAYVDYKTVLQIDCKIQLANDSINRITRILMNLDGPSWREKLSPIPAVPTSAHLRAWQLAVEPPPNQVGDSCSRPQPGITDEKMFKNLKEEGNQCVKDKNYKDALSKYSECLTINNKECAIYTNRALCYLKLCQFEEAKQDCDRALQIDNGNVKACYRRALAHKGLKDYQKSLNDLNKVLLLDSSIVEAKVELEEVTRFLNMKDNIASFNKEKERRKIEIQEVSEGQEEEPERTSEELFTHCMASENGDTTNGPPECDEELPITKPNNAYEFGQIINAISMRNDKEACAHLLAITEPKDLPVLLSNKLEGDTFFLLIQSLKNNLIGKDPSLVYQHLLYLSKAERFMMMLTLISKSQKEQIEQLFDDLSDTPNKHFTLEDVHALKRKYEL
The following text describes a protein:
Function:
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSQQQKQPCTVPPQLHQHEVKQPCQPPPQEPCAPKTKEPCHPIPEPCNPKVPEPCQPKVPEPCQPKVPEPCQPKVPEPCQPKVPEPCQPKVPEPCQPKVPEPCHPKAPEPCHPVVPEPCQPVAPEPCQPVVPEPCPPTVTPSPYQQKTKQK
The following text describes a protein:
Function:
Required maternally for germline survival by forming a maternal complex with gld-3. During hermaphrodite development forms a complex with gld-3 which promotes the sperm/oocyte switch freeing the translational repressor fbf to turn off sperm promoting factors. Required for proper oocyte differentiation and oogenic meiotic arrest. Stimulates the enzymatic activity of gld-4 and together they prevent gld-1 mRNA degradation.
Miscellaneous:
MISCELLANEOUS: Trans-spliced exclusively to SL2, suggesting a transcriptional coregulation with the upstream gene dhfr-1.
Subcellular Localization:
Cytoplasm. Cytoplasmic granule. Note=Localizes to P granules.
Sequence:
MRCLISYLFHSFLIFLKFIRSDVTALTLQEKRKKSRLTGILMKSMANKKNHQQKKSTDGSTMNGNNATATAAATTQNSSQIGQNSNSSHSVTNDNTSSNNASTSTSSITSTTTTTTTVPSSQQSQSQNQYSHQRLSSTSSTSQQTGISKFPAKKAGHNELEKTSNTANSQSGAFKGTTNKDRPKEKEKNTHSGNRQSQVNHNHHHSNHVSGNQQNRKNKNRDHSNQSYRGGYTHNHNNYHSLENAKSSGFLSNSSLSSAGQISASSAPPVSTTPTAIPIFQESKIVQTDPPVEEAKKKKEKPKIKRDEEPMPYKSTDPKNMDSVMAFKEHDEWDKVEFMCELVSFLSPTDLRLLGNCIEGSVRCYNNQMRPVEKTSNCSDPTAGLPQFVCSPPPPPQQVYYFPGIADAALYQTRNAVNSVFVQQHPPGLPPLLGGMQNIMYPPDANFHHSTSCTTPSSSVSVANKDVNNVPVVLSSSVNGISNNIPSDRQQLDSKPNTARGSSGNINQSNTTSPEPEPGSNHISTTAANPAHPTSVTVPQSVPPVPQEPELFLKSVLDLTSYIYTLMAVCSSTNRKSAAKISDYVQNVILREKSQILERIPDELDKITVLQEIGKIVAAMTHHPAITLDDKMKYAALRDGLRAQIETLFRQYYTTQKQLEQSNLVVPSSQAVGDENDTDSDHESEEEFEPLSGVMGSRFESNPVQPSPSVPGTFFIIRFIGRQIEKNDNLFSLEIHWSDGDRTFAQRSRDQLKALQHRLLDEFGQQRSEKYLHQGCTTSYSSFDDDNKKLSASTSTMETFAPNGERIVPRLARDATPAQYVQYINELSDLPARMMLSAVICEEFNGTRAKTEDLLQETREASDGLIYSRWKNPRAKSPVRYFKRNATGSIDPIELPVNMQPFLYSNIPQTQVQTLFPSCSNCGGPHAPKHCEKQTLLSKKGDHRTRSDGEGSQQNGGTSSSNSYAPIHANLPHAVYIENPQAMLGSNHFNHHQQQHIIQNTIFHNGGQFRANGTYEPQIPIAYYHAQGTVQNSNNTGGVNGNSGGGNQNSNF
The following text describes a protein:
Function:
Binds to the G-box motif (5'-CCACGTGG-3') of the rbcS-1A gene promoter. G-box and G-box-like motifs are cis-acting elements defined in promoters of certain plant genes which are regulated by such diverse stimuli as light-induction or hormone control.
Subcellular Localization:
Nucleus.
Sequence:
MGNSSEEPKPPTKSDKPSSPPVDQTNVHVYPDWAAMQAYYGPRVAMPPYYNSAMAASGHPPPPYMWNPQHMMSPYGAPYAAVYPHGGGVYAHPGIPMGSLPQGQKDPPLTTPGTLLSIDTPTKSTGNTDNGLMKKLKEFDGLAMSLGNGNPENGADEHKRSRNSSETDGSTDGSDGNTTGADEPKLKRSREGTPTKDGKQLVQASSFHSVSPSSGDTGVKLIQGSGAILSPGVSANSNPFMSQSLAMVPPETWLQNERELKRERRKQSNRESARRSRLRKQAETEELARKVEALTAENMALRSELNQLNEKSDKLRGANATLLDKLKCSEPEKRVPANMLSRVKNSGAGDKNKNQGDNDSNSTSKLHQLLDTKPRAKAVAAG
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MVGIDTGGKIPPEIMRQATEKTAQLAPLEGGHIYSILKQTLEKLALVGQLQVDPKVQAHELTQSVGEEISRMITEQKKLESRFEELVALQHVLRHQPNKTKLMENQVASERQALQLLLSNCLNEIEVFGKVQPLVESVMAQQAAEQAMKETIEREKNTTAAVRQLRNDLREEKLDHEEKMKEKKKGLSTLKEQLKALKMDTAVSTRYLSKDLTAGNEHERRLQRTQLEDLLKDLGLVQQQIDIEKAVHATQAEFLRQIAAKMADDSSNWASRHDGDLAAREKELEMLKQQHARDLIELKKAEEKFKMEQALKKEREMKATEERERAEFEEMRETRRAQAAVIIQAWWRGHKVRMVMSGGGKKGAKKGGAKKKK
The following text describes a protein:
Function:
Bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent, passive transporter (By similarity). Involved in the transport of nucleosides such as inosine, adenosine, uridine, thymidine, cytidine and guanosine. Also able to transport purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (By similarity). Involved in nucleoside transport at basolateral membrane of kidney cells, allowing liver absorption of nucleoside metabolites (By similarity). Mediates apical nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier (By similarity). Mediates both the influx and efflux of hypoxanthine in skeletal muscle microvascular endothelial cells to control the amount of intracellular hypoxanthine available for xanthine oxidase-mediated ROS production (By similarity).
Miscellaneous:
MISCELLANEOUS: Transport activity is insensitive to nanomolar concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR).
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MARGNAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQGRLAGTNSSAETMGTNHTSPTDTFNFNNWVTLLSQLPLLLFTLLNSFLYQCIPESVRILGSLLAILLLFALTAALVKVDLSPGLFFSVTMASVWFINSFCAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLMSLASGVDAQTSALGYFITPCVGILLSIVCYLSLPHLKFARYYLTEKLSQAPTQELETKAELLQADEKNGVPISPQQASPTLDLDPEKEPEPEEPQKPGKPSVFVVFRKIWLTALCLVLVFTVTLSVFPAITAMVTTSSNSPGKWGLFFNPICCFLLFNVMDWLGRSLTSYFLWPDEDSQQLLPLLVCLRFLFVPLFMLCHVPQHARLPIIFRQDAYFITFMLLFAVSNGYLVSLTMCLAPRQVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL
The following text describes a protein:
Function:
Catalyzes the condensation of L-2,3-diaminopropionyl-citryl-diaminoethane and 2-oxoglutarate to form staphyloferrin B, the fourth and last step in staphyloferrin B biosynthesis.
Sequence:
MQNHTAVNTAQAIILRDLVDALLFEDIAGIVSNSEITKENGQTLLIYERETQQIKIPVYFSALNMFRYESSQPITIEGRVSKQPLTAAEFWQTIANMNCDLSHEWEVARVEEGLTTAATQLAKQLSELDLASHPFVMSEQFASLKDRPFHPLAKEKRGLREADYQVYQAELNQSFPLMVAAVKKTHMIHGDTANIDELENLTVPIKEQATDMLNDQGLSIDDYVLFPVHPWQYQHILPNVFAKEISEKLVVLLPLKFGDYLSSSSMRSLIDIGAPYNHVKVPFAMQSLGALRLTPTRYMKNGEQAEQLLRQLIEKDEALAKYVMVCDETAWWSYMGQDNDIFKDQLGHLTVQLRKYPEVLAKNDTQQLVSMAALAANDRTLYQMICGKDNISKNDVMTLFEDIAQVFLKVTLSFMQYGALPELHGQNILLSFEDGRVQKCVLRDHDTVRIYKPWLTAHQLSLPKYVVREDTPNTLINEDLETFFAYFQTLAVSVNLYAIIDAIQDLFGVSEHELMSLLKQILKNEVATISWVTTDQLAVRHILFDKQTWPFKQILLPLLYQRDSGGGSMPSGLTTVPNPMVTYD
The following text describes a protein:
Function:
Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The AWS and SET domains are necessary for transcription repression.
Sequence:
MSSHDNADSPSSSVANAVTAMKIEQHDGAADMLLSNGGDAVLKRDSNGLSEHAVTAKDYPGMNDLASSTVKSRTSSLTPIKTENGDSTAKEEKVGGDITVKMEPGQPPKLSRSSSQKVVAQPPQLFLHLPDSTAEAQSTFEVMETCTYANKYMGYTEHAMECDCAEEWEPSLSRNLACGEDSDCINRATKIECVGDCSCGAECQNQRFQRKEYANVAVIKTEKKGFGLRAETDLRPHQFIFEYVGEVINEAQFRRRMRQYDEEGIKHFYFMSLSRGEFVDATKKGNLGRFCNHSCNPNCYVDKWVVGEKLRMGIFAERAIQAGEELVFNYNVDRYGADPQPCYCGEPNCTGFIGGKTQTDRATKLSNATIEALGIEDADSWDTVVAKRPRKKKMGEDDEEYVDSVQPKSLDENGVTKVMAALMQCKEKWIAVKLLRRIERCDDDRVRHRVVKMHGYQILNSQLTLWKDDFNVVLQILNILDGFPRLTRNKIIDSKIESTVQPLTTCGDERVEKKAAALLQHWATLEVGYRIPRMKRDPNAVASVSQFGRREHTTDEQKRSQSRSRSRSPSLDAPRGPANPGRKSNGPRNSQHHGARQFRRQFNPLPPGWFAAESHGRTYYYCARGDVTWTRPIHAAPEAEVPGQQAKNKALQGIIDNILNAKENTPKEKTVTPGTPQASRETASLNEGQERWRSYSEEKQKKLYENTLFPHIKYVVDKFKHKLPKEDLKRYAKDVAKKLVNSDFKNNRVEDPTKISEKQQKKVKAFCKEFFDKAVAKHRAYEQRKAEKQAKGGNSKADDMISGHNTVEDDVKLSDGEAEKVEENDNSMSSDPQGILKRKREDEMDIGEGAAEEAMKRQKSSTPIPPPPPPPPPLGDEEQPTPNGTGEDDFLAENGVSMLHSPGSAPTPPPPPPLSTEHSDNDEMGQSPSMSNHLLEQKSFPAPLGEEYEADSGKLSSNRIGIEGQV
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MNTLNLDIVTPNGSVYNRDNVELVVMQTTAGEIGVMSGHIPTVAALKTGFVKVKFHDGTEYIAVSDGFVEVRKDKVSIIVQTAETAREIDVERAKLAKARAESHLENDDDNTDIHRAERALERANNRLRVAELK
The following text describes a protein:
Function:
Neurotransmitter or neuromodulator peptides that mediate withdrawal behavior such as pneumostome activity in the respiratory system. Possibly regulates calcium levels in command premotor interneurons; [Peptide CNP2]: Involved in neural modulation of the cardiovascular system, in addition to or as part of, the peptide's role in mediating withdrawal behavior. Appears to have a function in both the ventricle and auricle chambers of the heart; the effects are both positively inotrophic, by affecting the magnitude of ventricle contractions, and positively chronotropic, by affecting the frequency of auricle contractions. In vitro modulates the spontaneous activity rate of parietal command neurons on motoneurons from the visceral ganglions that control pneumostome closure; [Peptide CNP3]: Likely to function as a neurotransmitter or neuromodulator that mediates withdrawal behavior. In vitro modulates the spontaneous activity rate of parietal command neurons on motoneurons from the visceral ganglion that control pneumostome closure; [Peptide CNP4]: Involved in neural modulation that mediates pneumostome movements in the respiratory system as part of the withdrawal response. In vitro elicits an increase in the rhythmic activity of pneumostome motoneurons, and increases the frequency and intensity of pneumostome movements. This suggests that this peptide, and possibly other HCS2 peptides, may be responsible for the 'delayed effect' influence of the command interneurons which consists of an intensification of respiratory movements. Also promotes the growth of neuron processes in cultured cells extracted from the pleural ganglia, and may therefore have a role in development and/or rearrangements of the defensive neural network.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Perikaryon. Endoplasmic reticulum. Note=Occurs mainly on the granule surface (Ref.3). Present in the perikaryon of command neurons in the cytoplasm surrounding giant nuclei (Ref.3); [Peptide CNP3]: Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Perikaryon. Note=Occurs mainly within the granule; [Peptide CNP4]: Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Perikaryon.
Sequence:
MQHQIRALLLFLLSGSACAMFYPRPKDYPRLGKRSFFTTVNGNHYPRIGRRDATGSSLVLPEADYTDLGDLTKRGVFTQGAHGSYPRVGRGGAVLSRDYLNERSKNLEKMSGDKDDDLEVDNGDGSRRLQAGHSGIPLEILFIAYDSDNDGKLSKEEFVTGLAQYQMQCPLY
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MKHTIIENEPEIKLQNDLNHHIEISPNTKTTNGTTTTTTTLNVNKTLKAIDLIETSIKNHISTIDHENCLPNDEDSFFVCDLGEIINSVNQWQQILPMVQPYYAVKCNSNPQILTTLSELGVNFDCASKNEIDLVLSLGIHQAHERIIYANPCKTNSFIRHAADENVNLTTVDNVHELYKLAKFHPHCKILIRLITDDSTAQCQLSTKFGCDLNTAIGEILPKAKELGLQVHGVAFHVGSGAKDFSSIYQAIKDSRILFDEMLSMGFTPKLLDIGGGFERETFPQSSQMVKFALEKFFPIEFSQLNEIKFIAEPGRFMVANAFTLITHIIARRDLPTGGNNNNNDMTPSAMLYINDGVYGNLNCILFDHQTPKVYVLTNENQLFYKQEMMRSLSVNNNNNNNNKTDGFKFSIWGPTCDGLDCVSSLAKLSKNVQVGDWLFFENVGAYTSCASTKFNGLSSGETKTLYVNSNEE
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MGPTWSEDPPPQQVSKGGLCKVYQRGAKIHHANKYRKGACANCGAMTHDAKSCFERARKVGAKFTGKHIAADEKIESIELDYAGKRDRWNGYDTSQYCQVQEKRFQDRKMARVDYLFKQSPEDESGNGEDVPNTSSAVSYEPALPKSRWEEDLFVNNHTTVWGSYWVDHQWGYRCCLQTEKESFCTA
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVNLNKVQPRSGGDHYLALGIEGSANKLGVGILKHPMLSQHKQGSLSHDCQAEILSNIRDTYITPPGEGFLPRDTARHHRNWVVRLVRRALVEAGIEDPRLLDVICFTKGPGMGAPLHSVVVAARTMSMLWDVPLVAVNHCIGHIEMGREITKAENPVVLYVSGGNTQVIAYSENRYRIFGETLDIAIGNCLDRFARTLKIPNDPSPGYNIEQLAKQCKNKDRLVELPYTVKGMDLSMSGILAHIDSLAKDLFRRNTKNYKLFDRETGKQLVTVEDLCYSLQEHLFAMLVEITERAMAHVNSNQVLIVGGVGCNVRLQQMMASMCQSRADGQVHATDERFCIDNGVMIAQAGLLQYRMGDIVKDFSETVVTQRFRTDEVYVSWRD
The following text describes a protein:
Function:
Promotes the exchange of Ras-bound GDP by GTP (By similarity). May play a role in chemotaxis.
Sequence:
MSYNSLTTIDIDITQLLHLKSVNLRSNKLGNSSGVSYFGSMDTLQKLNLKENYLTELPSTFYLLKLSSLKLDTFTPLYQQQQQQQNQLQRPIINSQSTSNESLIHEINRSFENLSMSEPVSPRIAALKNEKKGPPKPLPKTKGLHSSSSNINTSNNITPILMSPIHDGNKKSPSIISNNNNNNNSNSNIITSNGTVIPQLVFKNEPTGGRLRSFTLDADHISPGRELVSTGSSDEILYFNSEGGCENSDSDEPIQPLSAGRSRAQTISGKQPSIINNNNNNNSGGGSGNNNNSGGGGGSRKAFQNLIKSAKQIGSNIKNKTHHINGHSSSSQSNSTTNTPSISSTPYPTSTIKTNVSDTNTPVNYNGQQQISKVIQRVSGEIDPLYSGIDSPRTLERRNSSRDDIPISPPQGCMTPIKRLGSVEGDEISAIFSSSTDANMDVSQDYSSSTPTVNSMSYQSSFLDTFDNQSTVGSPTFYQLPVSSQPPQHPPPPPPIKDNNQPKLNQSQNLINTNSNSVTTTNNSSQTTTTTTTTTTNNNNVLNLEKLHKLDFAEDINGDERCSNPLYSKKKLAGLLFPNKHHQPSALKTAKIRFKSSKRLATTVNSNSSNNLMMSNSPLSSSSMNLLQQSNSPQYSGTPTSGSFQNQSVLSATLMSSPSMSDVFSGGNSQGGGSSLSQSGSITPVAPLSAVQGSPIGNSGSVNNIYLEGDDFIRDLMQSPIINQEIEFTSEDGVPKVKNITLKMLTSLLTHEKGQSNELNGIFFDTYLLFTSIPLVIEHLESRFLNGKNHIVKQKVITFSQKWVEVCWSDFKEEHIELLLKFLNDCSEQIEKLVTGSFALRTSLNLLLNIINMKRDGTYITEEEETFEQPAPIPDFIQLPNCVDINLMDLRPHEIARQLTILDHELLTQITKQQMLDYAVHQTNSPSIVKVTDRFNYLVLWVSTEIVLSLTIEKRIETIFKFVNIALNCWYLKNFNSAIAIIAAMSKPSIEKLKQTWGFIRNTKANAPIQELKELILPTNVARLRKIMDSVEAPFIPYLGAYFSHSIAIHAGNKSIVNEQYINMQKYDMMGKIIRSITVAQEKKYNLTPVGVLQKFLTDSFVLTEKQLYSEASKIEEKGDSYITETTKFGSIFKKKDK
The following text describes a protein:
Function:
Dimeric beta-barrel protein binding to heme and catalyzing its degradation to produce biliverdin. May function in the tetrapyrrole biosynthetic pathway.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MKSLVAHFSTPLITARLVPRCIIHRASISAVSFSTVRRRFSPLTMASAAQSSSQAVSYGSGNSDTDVFKLIQAHEEKAARLSPVEEIRTVLNGSICGMLSTFSQKYEGYPSGSMVDFACDADGSPILAVSSLAVHTKDLLANPKCSLLIARDPEDRTGLRITLHGDAVLVSEKDQAAVRSAYLAKHPKAFWVDFGDFSFMRIEPKVVRYVSGVATAFLGSGEFSKEEYQAAKVDPIAQYAKPVTSHMNKDHEEDTKAIVHNITSIPVESALMLDLDSLGFNVKATLQGNTFKLRVPFPRRAQDRKDVKTLIVEMLQAAKSN
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSSESKFYYVDTFSYQPSKPSAHENLTEKFELQDLAYKVRRVDEQGNKRKMRRSYKAYIQDLPGSIEIAKDNTIRQWYAEPRNGPVEVDLHQLHASFRLEPGLIPGFNSKIFGLDEDVTETMSRDSSMPRSPARRRKRV
The following text describes a protein:
Function:
Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane. Confers leflunomide resistance when overexpressed.
Miscellaneous:
MISCELLANEOUS: Present with 450 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
Sequence:
MYVTFNEALDSSFGNLESPNHDFKVGDPNMVPTPPMDSDSAAISLAFLISLSITFAILMLILVVIAAYVTFCGDDESEYDEENALGTRTSGTLHSLFGKKHSGILLDSSFASPGGFDDEIVLQERELEELPKMSAYEVELYIRAKEFQMMSPPMVKDFGTYLDSDDQQFIKDRGIQSYFLLPSINDNIDEYGNFLPSFIVQDKLDIQFSKFNKSSSTVMNYPLPHNRKDAVYFEVKIFRHIQKSNSIFSIGLTTVPYPYFRVPGMAKYSIAYESTGKLRINNPFTASTLLPKLEEGDTVGFGYRYKTGTIFITHNGKKLMDVTQNIGIDLFIGIGAFNAAYTRTYTRDGLLEDPDNVSFREALSEGKDIEVAKDLQRVHDPHDESDEMTSDEVELHVNLGQVGFVFIEANVKKYAFGSVYGQIGIPPAYNGTEIKKDTILQKGEELPPRYADTDNFFGSMKVKEGSSSRITAQTSKPLWSVGTYERISSNFDRENNVYHDSLETDDNNTDNNVNNNDENAGCNENSPLLEDDGNKRPENSNTPREVSDGAINKNPRNKSTKKRQRNRGKSSKKKNRSRK
The following text describes a protein:
Function:
Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability. M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers. The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+). Suppressed by activation of M1 muscarinic acetylcholine receptors. KCNQ3 also associates with KCNQ5 to form a functional channel in vitro and may also contribute to the M-current in brain.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Each subunit contains six transmembrane segments (S1-S6) with S1-S4 forming one voltage sensing domain (VSD) and S5-S6 contributing to form one quarter of an interlocking pore-forming domain (PD); The S4-S5 linker preferentially interacts with PIP2 in the open-state KCNQ2 channel, whereas the S2-S3 loop interacts with PIP2 in the closed state; The intracellular C-terminal domain is bound constitutively by calmodulin (CaM). This domain plays key functions in channel tetramerization, trafficking, and gating.
Sequence:
MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAGADKDGTLLLEGGGRDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFYESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPTKGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSFHQVTIDKVSPYGFFAHDPVNLPRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVSCHSQADLQGPYSDRISPRQRRSITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPNGGSSWMREKRYLAEGETDTDTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI
The following text describes a protein:
Function:
Phosphatase that converts 3'-phosphoadenosine 5'-phosphate (PAP) to AMP. Is also able to hydrolyze inositol 1,4-bisphosphate but with less efficiency.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFDKELALALEIVQVSCKITTSVAEHTLTDQTQIKNDKSPVTVGDYSVQAYVNKKIHETFPEDQIVAEEDTKTIPEDIFAKVCKHVQIYSDMKDDEIRKSIDLGNSTGGKGRHWVLDPIDGTLGFLRREQYAVCLAFMIDGDIKVGVLGCPNFEGGLIVAAQKGCGAKMFSVNDIKNGKDIHVSTTPKTSDMCFCESVEVSHTDQSRSKTITERLQVTKPPVRMDSQCKYMAIASGRADVYLRLPRNLSYQEKIWDHAAGYLIVKEAGGKVTDIYGNDLDFSLGRTLCNNHGIVASNGILHEETVNVVKDVLSDLK
The following text describes a protein:
Function:
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response. CSN12 forms a complex with THP3 that is recruited to transcribed genes and required for transcription elongation.
Miscellaneous:
MISCELLANEOUS: Present with 1510 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDVDIGCYFEEKRYDDKLLDFIRYDVKTPKKTKYILQRPTATDEESVRLQRFYQLGVDLKLKYSKRRSLKKQGRIKNATEELLRLANEQLKLFNRIVERETNWIIYPLWVMAKQLIRLANESSELNKDSIEECGRTIHRSFTICLNDRNPRLNENKKIGCYMFANLEFSIYHRLSNKDMIKNLVKVLESRVNARDIPPLNKSLAMEHKSQVVLYNYYLGQYYGCLENDHERGFFHLNEALLQCPMLYVESTGKFVLQGQMEKIMILLVPLALLTKRLYPHWDHPVIAGVITRSKRLSQVYPTLVRSVISGNLSLYEATAASHERFFLSQGLHVVITLLREVVFTRLVQRCWQWGNDRKSIMPLKILLATKQHDSSANEDEEEQLDALECRLASAIASGLLRAYLSHSNRCIVFSKKEPFPHSK
The following text describes a protein:
Function:
Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.
Subcellular Localization:
Membrane raft.
Sequence:
MDMVMNMERTEDFKALRAKFQNDSNFSNTLLTPAKKPPVVTRPQSSDGNSLPHPKPKPLSHIQVPEIIPRQNSNGNSTSCPKPLGQVQFAVPEQKTEKFSYISHPSEITPVKPRALPRVRLRDLSEVEKNNDRKDSDFPGTLGKRPIPGADLQKQRPASFVHPEEILSGKPTFQNTRKLWESASSLNSDQKSSTAPPQYPNRTTSLGYLKTANDVTDVPKDKDKSVENEQAPKNPSQCEATQFLIVSPPVPPRNHMTVDKVACEAVKPIDSSTNTNDLNKASMTLHCSNAWQSSPNSSVEGHPHGEETHLSKAKSLPSIIPPHRERHHDGGETRLLKIKPLPPIKSLGPPPKKPPRPPKVDLSNFQMIIHEAVDDAYMTPEITEIEELSTYEETLSCLVHPECSNSIHEAKHIPKAGKKEDAKKQNFLVAIPSSEIKDSKERGPLWNHDAPKQQAKETSKVSDRNAVLTNMKMNGENRGEKHVTQEETIQPSPGKRLTVDGNFSDGYVCLENLIVDEEKASTTAPTSMQTVEEVYDDVEGLQSDLQACDAYSSFTSDTFADENNEETYEDVQTEEYNSTKSEDGKVEKLKGLGKFFKKGKFKVRNANMKENFRNLSRSAPNLDVIAQETMVYNNVDTEQTDANSSPRNFFKIKKYNLEKNNKMSKEEKLFREKFMYDKEITVINTAVAHCSNASTKGKRDLKITAGEQLEVIDVTEGNQLICRNSEGKYGYVLLEHLNFRH