lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
Subcellular Localization:
Mitochondrion.
Sequence:
MLPALKLLRAGPRLRPGPALADRLSRCHGGARKPRVAPDPAPGPSPRRDRAGVGAGESSEAEVSLDVVSPEVKTELDFDRAIRAEFTDQLKLLKKRFLDHLVGPEGRPMTEVLLENAKVVWRFRGPGDLDRWTVTSDKTVGGRSEAFLKMGRNNQSALLYGTLNTEVPRDGQTRYSGYCAMISGIPRGFLDKKESYDWSSFNTLYLRVRGDGRPWMVNIREDTDLFHRRHLMYSYFMFTRGGPYWQEVKIPFSKFFLSSHGKVRDGQFRLLADKVATVGFTLADKVNGPFFLEIDFIGVFHDPAHVEEFAYENTEVLCPRL
The following text describes a protein:
Function:
Serine/threonine protein kinase required for spermatid development and male fertility.
Subcellular Localization:
Cell projection, cilium, flagellum.
Sequence:
MEEFLLSHGYQVGKTIGEGTYSKVKEAFSKKHQRKVAVKIIDKRGGPEEFIERFLPRELQIVKRLDHKNIIRVFEMLESTDGKIYLVMELAEDGDVFDCVLQGGPLPEGRAKALFLQLVDAIRYCHSCGVAHRDLKCENALLQGFDLKLTDFGFAKLLPKNRKELSQTFCGSTAYAAPEVLQGVPHDSRKGDIWSMGVVLYVMLCANLPFDDTDIPKMLCHQQKGVSIPGHLGVSEECQDLLKSLLEPDMVLRPSIEEVSWHPWLASS
The following text describes a protein:
Function:
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP.
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, gem. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs and in the nucleolus.
Sequence:
MDLGPLNICEEMTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSAAAHSQPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELLKSLEASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQDPLLSQFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRKCCALANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEAERDVSLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFSQNATLYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMDRHMEVCYIFASEKKWAFSDEWVACLGSNRALFRQPDLVLRLLETVIDVSTADRAIPESQIRQVIHLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQSASEQGLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEEQGPNSSATFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFVLPFLRLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPKEKRCLSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKSFFEGHFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLLVVDVGNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQFVPLLNLKPFAQELQLSVLFLRTFQFLCSHSCRDWLPLEGWNHVVKLLCGSLTRLLDSVRAIQAAGPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLSKTNPSVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF
The following text describes a protein:
Function:
Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere, Z line. Note=Localized at the Z-line of skeletal muscle.
Sequence:
MIPKEQKEPVMAVPGDLAEPVPSLDLGKKLSVPQDLMIEELSLRNNRGSLLFQKRQRRVQKFTFELSESLQAILASSARGKVAGRAAQATVPNGLEEQNHHSETHVFQGSPGDPGITHLGAAGTGSVRSPSALAPGYAEPLKGVPPEKFNHTAIPKGYRCPWQEFTSYQDYSSGSRSHTPIPRDYRNFNKTPVPFGGPHVREAIFHAGTPFVPESFSGLELLRLRPNFNRVAQGWVRKLPESEEL
The following text describes a protein:
Function:
Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MIFFTITGSLTAAIVYDRRERRRVQQKWCDLVAHLSKETLPIEQTRRKLTIFLSAPPGDGLRIAREHFKEYVKPILVAAALDYTVIEGRREGDVRAALAERIRKHRRKAGEPSSVVEEMSNEDIIADARQKIGVVEEPGPKGDLVIGRHTWKEYIRGLHEGWLGPLDPPSPPDAPVKGPSVPVEGSETPADGTPAEENTEKKEEAEKKDDKPAKPSGPTPAYVSPAEYSSRSLPPTLPQSLDSSVPIPFPHLLGFLNTPIRLYRYLSRRHLADEIGREVAGLVLASSSRPYHDGSFSSDSELSGAMVDAGASTLSSPDDMMPSSSAKYEQQTVLEKEESEWHKSVHKRDEENPDKEREWIDDIVLDPRIASRMQRSLLSADEEARSQRITEGKEYILGEERPAPVSFWQRMWIKYGYGEDEETIRMKPIIGNLDGADGE
The following text describes a protein:
Function:
Possible ligand of InR/insulin-like receptor; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway.
Miscellaneous:
MISCELLANEOUS: Of the insulin-like peptides, Ilp2 is the closest homolog of human insulin.
Subcellular Localization:
Secreted.
Sequence:
MSKPLSFISMVAVILLASSTVKLAQGTLCSEKLNEVLSMVCEEYNPVIPHKRAMPGADSDLDALNPLQFVQEFEEEDNSISEPLRSALFPGSYLGGVLNSLAEVRRRTRQRQGIVERCCKKSCDMKALREYCSVVRN
The following text describes a protein:
Function:
Membrane-bound serine protease. Through the cleavage of cell surface hemojuvelin (HJV), a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Note=The processed, activated two-chains form is released in the extracellular space.
Domain:
Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s).
Sequence:
MLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELLSTVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVAGPLEKRLITSVYGCSRQEPVVEVLASGAIMAVVWKKGLHSYYDPFVLSVQPVVFQACEVNLTLDNRLDSQGVLSTPYFPSYYSPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLPCTQGQWTIQNRRLCGLRILQPYAERIPVVATAGITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVNGLCVPACDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNALQKVDVQLIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQVVT
The following text describes a protein:
Function:
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
Subcellular Localization:
Peroxisome matrix.
Sequence:
MAKYNNNSNASKATNLKQQVVLPTYTLDSNLVLLPGIMYNVTFSRFKAAALLYRYKNFISQVSIINNLLNEYDFNSGNTNEEERFEAEQKLEQPETYHEINPSVISPEAVEGIKEFFQYETGMKTGRGVEKGVKSTQNDAIKEFDWLTLAIIPNLEKIKNPETNSSAGDGSSSSKVVTVARIVGIVDDTTNIKLTLQAITRGVQIKDDGKNNHHKRGLKTNEQVIGIDWNHNVSDLKGKFTTLQKNYQQLFQSIDKFLIDYREALDYNKNNSNNNNNNNNNRNGNLSLIKGNSTTYSNNKNYDDKPNQDIKSQNLLTLNPLANALYMQLVGSKDFNKAFHRLQKLFSQVIQGDEYKIDNETYLRLVDLTCGILPFPNFQKLALLNEYKLDDRSILINEMMSQLIQIFGNLQTNTSFVNSWFHSEATNIQKATVVANQLKSIRNLLEGMTKNRPIKPNKRNSGPASSAPSFSNGKTPPARPKVNHHQDGSHGHDSDYDNNDDDDDGDEDLKAIFNFIKHKLPTISSLSADSKRLILKDFKRVKASANSPGGGGNSDFHVLRNYLEIVMDIPWDNYVTKFKSNKDIDLKLAKKQLDDDHYGLEHVKKRLIQYLVVLKLLGINAEKDQALQSKDEENSKNPAHSDSNSNSNCNSNSRSLTKSPTSSLASKTPSSIVIANNDETYLAKQQAKTRNQKSITEAKTNVSTKMVPSNESIQVSKNNKSPIIMLAGPPGTGKTSLAKSIASALGRNFQRISLGGIKDESEIRGHRRTYVGAMPGLLIQALRKSRCMNPVILLDEIDKVIGGNSGGVNKFNGDPSAALLEVLDPEQNNTFIDHYLGFPVDLSQVIFICTANDPWNMTRPLLDRLEMIEIGAYDYNEKLIIGKKYLLPRQIKRNGFPVTKVGKNNTGNQDEFIKINDDTMKKVILDYTRGEAGVRNFERRLGTLCRFKAVEYCEWLNKDIKNYNPIIDENDLPIYLGVPYSSGDVTTEGTVGVGVVHGLSYNSDGSGSVLVFESIGFDRRISNGNKEHNGGDGSGGNGATLNMTGRLGEVLMESGKIGLVFIKSMIYKNILKFDNNNNNNTNRHLLLDKYNNLDIHMHVPMGSVSKDGPSAGVTMALSFLSVLLDKPVPSDIAMTGEITLRGIVLPIGGVKEKLMGAHLNANIKRMIVPRENRKDLIKEYSRSIEEAGEVLDHHLINDLIKDNEDNEFKLTQVEDYYQNKYGISLFYAKEFYDIIKIVWNEDEVLLKENNSRLLEYHI
The following text describes a protein:
Function:
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
Sequence:
MLKEKNSAGGGKFNFFNFLKEKDNNQAEPSNVKEFISYLKNKIINEKYEITREEAIFLSQIPNNDMETLNILFNAADQIREVFCGKYFDLCTIINAKSGKCSENCKYCAQSVHFKTGTDVYGLISKELALYEAKRNENEGAHRFSLVTSGRGLNGNEKELDKLVEIYKYIGEHTSKLELCASHGICTKEALQKLVDAGVLTYHHNLESSRRFYPNVCTSHSYDDRINTIKNAKAVGLDVCSGGIFGLGETIEDRIDMALDLRALEIHSVPINVLTPIPGTPFENNEEVNPFEILKTISIYRFIMPKSFLRYCGGRIKLGEHAKTGLRCGINSALTGNFLTTTGTTIETDKKMIKELGYEI
The following text describes a protein:
Function:
Mediates the uptake of pyruvate into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSTALKAFINSPVGPKTTHFWGPVANWGFVIAGLVDMNKPPEMISGNMTAAMCVYSGLFMRFAWMVQPRNYLLLACHASNESVQLYQLSRWARAQGYLEKKEPEAQQ
The following text describes a protein:
Function:
Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).
Subcellular Localization:
Nucleus.
Domain:
The PPC domain mediates interactions between AHL proteins.
Sequence:
MDRRDAMGLSGSGSYYIHRGLSGSGPPTFHGSPQQQQGLRHLPNQNSPFGSGSTGFGSPSLHGDPSLATAAGGAGALPHHIGVNMIAPPPPPSETPMKRKRGRPRKYGQDGSVSLALSSSSVSTITPNNSNKRGRGRPPGSGKKQRMASVGELMPSSSGMSFTPHVIAVSIGEDIASKVIAFSQQGPRAICVLSASGAVSTATLIQPSASPGAIKYEGRFEILALSTSYIVATDGSFRNRTGNLSVSLASPDGRVIGGAIGGPLIAASPVQVIVGSFIWAAPKIKSKKREEEASEVVQETDDHHVLDNNNNTISPVPQQQPNQNLIWSTGSRQMDMRHAHADIDLMRG
The following text describes a protein:
Function:
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
Subcellular Localization:
Nucleus.
Sequence:
MSIPGFGSAEKVNHTASSVTLTIPQSYEWRIEVPFNRILKFKVLTGIVEINGTELANNTEIQLSGTKTYLYSPVTDAVIEYVLVENKDDLSLVSASDEGFVEYLSDESNMDSILNLHMYLESKRQYTKDYNFSSSIDQQQSGPKVLIIGSKYSGKTTVSKILSAYANKMNNTPVLVNLQPRDGVFALPGSLTATPISDSFDVESCNGYGLTTTSGTLVHNPKQPIVKNFGMADFNDNVDFYKLLIEKLGIAVLSRLDQDLNIKNSGVIIDTPALTSKNFDIVESMVSNFLIDNIIVIGNERLAIELTKKFAYKSTQLNIIKLNKSSGCIEVEDRFIRLQQEQTIKEYFNGNFKTRLSPFKTDIELSGLKIYKNVLTKDLLSQMAFLPGGDDFEKDETNPEEDPEKKQLEKYYQAIEDPNSSNLENSIVAITHLPNNDKKLGKDLLNTSVLGYIHVSKFDDQKKRLKVLFPFPGVFPKNVLISTNIGYNE
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Domain:
The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.
Sequence:
MNLYKEFQMPKKVEFDQESLTDTYGKLVIEPLERGYGITLGNSLRRVLLSSLDGVAVYAIRINDALHEFSSIKGVKEDILDIILNVKKLRFKYYAQDSDKKIATIKIKGPADVTAESIQTDGTYEVLNKSQYICSLDQDAQMEMVLYIRKGRGYVPSEAIKDDELPVDAITVDAIFSPVKKVNFRVEKTRVGELTDYDRLILEIWTDGSITPERAISDASSILIKHFEYLIFFKEAELQNKEIHETVPNPEEDLNFDLLNENILKPIEDLELSVRAYNCLKSAGINTIAELVQRTEGELMKTKNFGRRSLEEIKEVLTNMGLKLGMRINPELLEKFKEKAHRG
The following text describes a protein:
Function:
Possesses antifungal activity sensitive to inorganic cations.
Subcellular Localization:
Secreted.
Sequence:
MAKFVSIITLLFAALVLFAAFEAPTMVKAQKLCERSSGTWSGVCGNNNACKNQCINLEGARHGSCNYVFPYHRCICYFPC
The following text describes a protein:
Function:
Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation (By similarity). May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MSGSFSPCVVFTQMWLTLLVVTPVNGQHEAAQQSVVSLQPPWTTFFRGEVVTLTCYRFGFSVPQKTKWYQKRKTVKQTPGALVIKAHTLKVHESGEYWCQADSLLPSMHVNVEFSEDFLVLQAPPAVFEGDSVVLRCYAKKGIEAETLTFYKDGKALTLHPQSSEFYIHRANLKDNGQYKCTSKKKWSFGSLYTSNTVVVQVQELFPRPVLRARPSHPIDGSPVTLTCQTQLSAQKSDARLQFCFFRNLQLLGSGCSRSSEFHIPAIWTEESKRYQCKAETVNSQVSKQSTAFIIPVQRASARFQTHIIPASKLVFEGQLLLLNCSVKGVPGPLKFSWYKKDMLNKETKILKSSNAEFKISQVNISDAGEYYCEANNSRRSFVSRAFPITIKVPVSQPVLTLSTGKTQALEGDLMTLHCQSQRGSPCILYEFFYENVSLGNSSILSGGGAYFNFSMSTERSGNYYCTADNGLGAQCSEAIRISIFDMTKNRSVPMAAGITVGLLIMAVGVFLFYCWFSRKAGGKPTSDDSRNPSDSEPQEPTYYNVPACIELQPVYSNEPEENVIYTEVRRTQPRQKHADQESESPRSRCQMAEKK
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system TakPQM involved in the uptake of alpha-keto acids. This protein specifically binds alpha-keto acids including pyruvate, oxobutyrate, oxovalerate and 4-methyl-2-oxovalerate. Ligand-binding affinity increases with the increasing chain length of the aliphatic backbone of the ligand. Is not able to bind alpha-ketoglutarate.
Subcellular Localization:
Periplasm.
Sequence:
MDRRSFITKAAVGGAAASALAAPALAQSAPKVTWRLASSFPKSLDTIFGGAEVLSKMLSEATDGNFQIQVFSAGELVPGLQAADAVTEGTVECCHTVGYYYWGKDPTFALAAAVPFSLSARGINAWHYHGGGIDLYNEFLSQHNIVAFPGGNTGVQMGGWFRREINTVADMQGLKMRVGGFAGKVMERLGVVPQQIAGGDIYPALEKGTIDATEWVGPYDDEKLGFFKVAPYYYYPGWWEGGPTVHFMFNKSAYEGLTPTYQSLLRTACHAADANMLQLYDWKNPTAIKSLVAQGTQLRPFSPEILQACFEAANEVYAEMEASNPAFKKIWDSIKAFRSEHYTWAQIAEYNYDTFMMVQQNAGKL
The following text describes a protein:
Function:
Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
TLCKLVQRQTYSCLSHKFGIYMAYAGIVIVLYSVFHFGEEVLVWSRNKYDVAFSAYHDNIASTSFQNRLCSEVPIDIVYTWVNGSDPELIKQLNELKSKMSLNLSSEQSGIPADITCNLKDCIKLPLLSVLPMIKDLTLEMAKVKYSSVKNLQSVFTLDLPNNHNLNFFFLIFRFKTVDDARTMQVNNNKTNHTMFQAHVTSDASAPHSMRLTSAFILTSIPKQFKTEAEVKENLPQLLKDKLNWLHFSSSKNSAFIWLTDSTLVDEFAKEKGNSTLKLGFVMGSTYNKVDVKLAYFVGRVEPHESEDVISKSRFEDNEELRYSLRSVEKYAPWVRHIYIVTNGQIPYWLNMDAPRVTLVTHEEIFVNKSHLPTFSSPAIEAHIHRIPGLADKFIYLNDDVMFGKEVWPDDFYTHADGHKVYLAWSVPNCAEGCAPSWITDGYCDTACNVSACEWDGGDCTGEMAYPGKNIKPGVGAASNFGANSWRSTVSYCKPGCSNSWIADRFCDQACNTYECGFDAADCGISNFDKAYKIPGLINESVYQIPDGQHLAYIDLSKKFAKVSSASYEKNVNLRAAAVSNKFHMVVTIMLKGMTAQKPYLINLKFGRTHQAKTPTTQTTQSLNQPWMEFEPQQKFLSLKIISFILPAAENVEYDNIIELPEEFKRPQISRLQKEEAPDLPISEDDLNITILPEEVRKTYLKYKEELSLGYLTRKGYNSSVYHILSPYFELIRQNYVTKPHSEHEVTTVQQDDINVNGHSHNRGDPGFVSNTENKRKKVEVDHLRFVVVLHLTMDTTPYKNNNKIFRKQNTSNVESKSSLTSRKLLSIGSLKEQSDNESQTLGEILQNQPPNVDGFLPWENKKEMVKFQQQLEENERKKATEERLPFFVLLKRKLLDTFGDSLRFVSLLYNKKYGFTQRKVPAHMPHMIDKNIMCKLQSNYPHEYDMTSSHKLRHSQDMQFAFSYFYYIMSELKQFNVSEIFDELDTDHSKVLSDREIRLLATQIFDLPLTLDELTSLESAFKKCAMDLYAGPNMPIDGLSPLAASETYYDKEMPLVTREIVLSCDFITNKLNKTYSGRKKYKYVQLDETEVSFKMIRSNVSVVVGQLDDIRKHPKKFICLNDNIDHTSKGAETVKAVLQDFYETLFPTQSQFELLHDYRNRFMNIHDLREWKQNHERTLFIMHSILIFLLFAIIISFFWDQIYRFWRRHRHKVFRRGVLKVWKLKNKPRDPV
The following text describes a protein:
Function:
Fatty acid hydroxylase; part of the gene cluster that mediates the biosynthesis of the glycolipid biosurfactant ustilagic acid (UA). UA is a secreted cellobiose glycolipid that is toxic for many microorganisms and confers biocontrol activity to U.maydis. UA consists of 15,16-dihydroxypalmitic or 2,15,16-trihydroxypalmitic acid, which is O-glycosidically linked to cellobiose at its terminal hydroxyl group. In addition, the cellobiose moiety is acetylated and acylated with a short-chain hydroxy fatty acid. UA biosynthesis starts with omega-hydroxylation of palmitic acid catalyzed by the cytochrome P450 monooxygenase cyp1. Terminal hydroxylation of palmitic acid precedes subterminal hydroxylation catalyzed by the cytochrome P450 monooxygenase cyp2. Sequential glucosylation of the hydroxy fatty acid is probably catalyzed by the glycosyltransferase ugt1 (Probable). The cellobiose lipid is further decorated by acetylation of the proximal glucose residue and by acylation with a short-chain beta-hydroxy fatty acid at the distal glucose residue (Probable). The acyltransferase uat1 may be a good candidate for catalyzing either acetylation or acylation of the cellobiose lipid (Probable). The fatty acid synthase fas2 may be involved in synthesis of the carbon backbone of the short-chain beta-hydroxy fatty acid esterified to the cellobiose disaccharide (Probable). The secreted UA consists of a mixture of both alpha-hydroxylated and non-hydroxylated glycolipids; therefore, alpha-hydroxylation of the long-chain fatty, catalyzed by the fatty acid hydroxylase ahd1, occurs late in UA biosynthesis and may be the last step before secretion.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTTRTATSTSTTVHGHLGDLKLRNAAITGPHLQPKAAKQDLADTKPDSARTFPGLGFKLSPTEERLRAKRNWGFLETAYDNSKVMGLTTHFVTITMAIVFNKSWLAKPVYDWLNTYDRFTIHTVHTWILLSTCQLLVIGLFALTDLSGRPSWLARYRMQPHKPPTLAQYKKLIPVVLFNLVVVNTISNIIYYPLAEWRGIQTTYETLPSGKKLVAQWLVCLLMEDIGFYTVHRALHHPRIYKYIHKKHHEFSAPIAGASTYAHPLEHYFSNLVPILVGLLITRAHISVQYLFFTGLMIGSHVQHSGYNIPFLTCALVHDWHHYFNTENYGPVGLLDAIFKTNKTFKAWTSETVAAFHGDRAKARQAALEKLAQIEAEEQERIR
The following text describes a protein:
Function:
Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MDSTKTNNKWAAAGILNSVGKDFVAGSVGGMSSIMAGHPFDTIKVMLQDASGNLPKFKNGFQALKYIMKVDGIKGIYRGLSVPLFSVSFTNSVFFATNNFCQSYFHPPCKDENGEDILIPYHKAAAAGAIAGGVISLLITPRDLVKSKLQVQCRPFGSTNVSLQYKGPIDVIRQTIKRDGIKGMFKGIRSTFCRDIPGDAVYFVVYEFMKRKLLALSKNNNNNNNNNDNNDNSSPKAGVPAWVAIGAGGCAGMSFWMSIYPMDVVKTRIQTQPDHLPPQYTSVLQTITKIYREEGISVFFRGFSATILRAFPTSAVNFLMYETTRNLLNSKDPFYNNNDHYNAE
The following text describes a protein:
Function:
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Miscellaneous:
MISCELLANEOUS: The reaction proceeds by a bi uni uni bi ping pong mechanism.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTPTPPVLLRTAGELHARVRRGRRAVVMTMGALHEGHATLIRTARDIAGPDGEVVVTVFVNPLQFGAGEDLDRYPRTLDADLEIAGRAGADAVFAPAVDEVYPGGEPQVRVTAGPMGGRLEGASRPGHFDGMLTVVAKLLHLTRPDLALYGQKDAQQLALIRRMVRDLNFGVEIVGVPTVREEDGLALSSRNRYLSTAERRTALALSQALFAGLDRHAAQEALCARAREVPATQARAEALSALGESRAAADAHAVATSAPGSATAVRDAARLVLDDAARATPPLELDYLALVDPSDFTEIGDDHTGEAVLAVAARVGATRLIDNVHLTFGPLGAAS
The following text describes a protein:
Function:
Involved in the export and assembly of pili subunits across the outer membrane. Forms a hexameric ring-shaped pore in the outer bacterial membrane. The 2 nanometer-diameter pore allows the passage of the thin tip fibrillum. As for the rod, it probably unwinds into linear fibers which would therefore be narrow enough to pass through the pore.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKDRIPFAVNNITCVILLSLFCNAASAVEFNTDVLDAADKKNIDFTRFSEAGYVLPGQYLLDVIVNGQSISPASLQISFVEPALSGDKAEKKLPQACLTSDMVRLMGLTAESLDKVVYWHDGQCADFHGLPGVDIRPDTGAGVLRINMPQAWLEYSDATWLPPSRWDDGIPGLMLDYNLNGTVSRNYQGGDSHQFSYNGTVGGNLGPWRLRADYQGSQEQSRYNGEKTTNRNFTWSRFYLFRAIPRWRANLTLGENNINSDIFRSWSYTGASLESDDRMLPPRLRGYAPQITGIAETNARVVVSQQGRVLYDSMVPAGPFSIQDLDSSVRGRLDVEVIEQNGRKKTFQVDTASVPYLTRPGQVRYKLVSGRSRGYGHETEGPVFATGEASWGLSNQWSLYGGAVLAGDYNALAAGAGWDLGVPGTLSADITQSVARIEGERTFQGKSWRLSYSKRFDNADADITFAGYRFSERNYMTMEQYLNARYRNDYSSREKEMYTVTLNKNVADWNTSFNLQYSRQTYWDIRKTDYYTVSVNRYFNVFGLQGVAVGLSASRSKYLGRDNDSAYLRISVPLGTGTASYSGSMSNDRYVNMAGYTDTFNDGLDSYSLNAGLNSGGGLTSQRQINAYYSHRSPLANLSANIASLQKGYTSFGVSASGGATITGKGAALHAGGMSGGTRLLVDTDGVGGVPVDGGQVVTNRWGTGVVTDISSYYRNTTSVDLKRLPDDVEATRSVVESALTEGAIGYRKFSVLKGKRLFAILRLADGSQPPFGASVTSEKGRELGMVADEGLAWLSGVTPGETLSVNWDGKIQCQVNVPETAISDQQLLLPCTPQK
The following text describes a protein:
Function:
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MPCRREEEEEAGEEAEGEEEEEDSFLLLQQSVALGSSGEVDRLVAQIGETLQLDAAQHSPASPCGPPGAPLRAPGPLAAAVPADKARSPAVPLLLPPALAETVGPAPPGVLRCALGDRGRVRGRAAPYCVAELATGPSALSPLPPQADLDGPPGAGKQGIPQPLSGPCRRGWLRGAAASRRLQQRRGSQPETRTGDDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGPLSAPVHEPPSPRSPRAACSDPGASGRAQLRTGDGVLVPGS
The following text describes a protein:
Function:
Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTLTAQQIACVYAWLAQLFSRELDDEQLTQIASAQMAEWFSLLKSEPPLTAAVNELENRIATLTVRDDARLELAADFCGLFLMTDKQAALPYASAYKQDEQEIKRLLVEAGMETSGNFNEPADHLAIYLELLSHLHFSLGEGTVPARRIDSLRQKTLTALWQWLPEFVARCRQYDSFGFYAALSQLLLVLVECDHQNR
The following text describes a protein:
Function:
Putative gamma-glutamylcyclotransferase.
Sequence:
MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGPTVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKDGCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVLKGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVDVEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPKG
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MEQLDVEDWEYWGDEYLEEEPTYAIRPGTRVVKVERVPMMRGDLRTSGATSSSGPATSYIIRPSDKQPTVSSGGSQNGDSVCAVCGDGIAKLHYGVLACYGCKGFFRRTLTGKYRYACRFSNNCIVDKFQRNSCRYCRFQRCIQAGMDPKAVRPDRDQTGKQKVPRIKKKQIDEELLNHMMRLQGDDWSRKLPVETRILLMQLMSIEDKVVKGDNNMSAQNTAKDPKSISLREMFESKPALDGRRMEIGYEPFRMARTEELGVIAHRRAIAAVDWVDSLTEIADAVDTEDKVALVKSCYSPLTIFNFSARTAQNTKNPDILCLCSHSFVPRRLPPEFNETNHLSNFLIDRTLNELVAPLRKLNLKEEEIVPLKAIIILNPNAKGLSEHARHAISELRDKVQDMLFQIVKELHPIYSASSRFGNLLLLLPTITTLSGLMSENMHFCQALGGRASGDNLLAEMFGDRTFDDQLISSSISPPLFENPAEICLESISPPMSDRRFVRRVDVATQTNDDLLSSGPYLPHSNSCSSMLNAGYSPPMLSTSPFPLLDDNDSAFQNDISLTELNGCEEFFSQLMDQPIIDS
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MLPLENVVLCRESQVSSLMALFGERHHFSFPSIFIYGHKASGKTYVMKTLLKTSELPHVIVNCVECFTSRILLEQILNQLNCLHYSEDEYTSHIACDSFNDFVRLFKKVTQERGVDDQTVYIVLDKAEYLREMEANLLPAFLRLQELTNRNVTVIFLSQIVWEKFRPNTGCFEPFVMYFPDYSIGHLQKILSHDHPPEYSADFYAAYINILLGVFYTVCRDLKELRHLAALNFSKYCEPVVKGEANERDTRKLWRNIEPHLKKAMQTVYLREISSSQWEKLQQDDTEMGQLKGLSAHAHIELPYYSKFILIAAYLASYNPTRTDKRFFLKHHGKIKKTNFMKKHEKTSNHLLGPKPFPLDRLLAILYSIVDSRVAPTSNIFSQITSLVTLQLLTLVGHEDQLDGPKYKCTVSLDFVRAIARTVNFDIIKYLYDFL
The following text describes a protein:
Function:
Probably involved in peptidoglycan hydrolysis.
Subcellular Localization:
Secreted.
Sequence:
MFVYYCKECFIMNKQQSKVRYSIRKVSIGILSISIGMFLALGMSNKAYADEIDKSKDFTRGYEQNVFAKSELNANKNTTKDKIKNEGAVKTSDTSLKLDNKSAISNGNEINQDIKISNTPKNSSQGNNLVINNNELTKEIKIANLEAQNSNQKKTNKVTNNYFGYYSFREAPKTQIYTVKKGDTLSAIALKYKTTVSNIQNTNNIANPNLIFIGQKLKVPMTPLVEPKPKTVSSNNKSNSNSSTLNYLKTLENRGWDFDGSYGWQCFDLVNVYWNHLYGHGLKGYGAKDIPYANNFNSEAKIYHNTPTFKAEPGDLVVFSGRFGGGYGHTAIVLNGDYDGKLMKFQSLDQNWNNGGWRKAEVAHKVVHNYENDMIFIRPFKKA
The following text describes a protein:
Function:
Catalyzes the ferrous insertion into protoporphyrin IX.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTLTNQKPLGVLFMAYGGPENLGEMPGYLADIRAGRVTSQAILDEITNNYRLIGGKSPLPEFTRAQVEATMEQLASTGRPLKAYIGMRHWSPWIEDAVREMLDDGIEQAIAIVLAPQYSSLSVAKYQKKIKAALEMNHGHIDFAYIDNYHTEPGYITALADRVRIGIQEFPEDERDDVHVILSAHSLPVRIIKEGDPYADQLHETARLVAAQAGLTDEQWSWSYQSAGRSPEPWLGPQLDEHLRDLNEQGIKKVVSIAIGFVSDHVEILFDIDIAAQEVAHELGMTLVRPPALNTDPLFIGTLASVIERKAAEVA