lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.
Subcellular Localization:
Cytoplasm. Membrane; Single-pass type I membrane protein. Nucleus.
Sequence:
MLPGAPDPLESRRRRRGKLPGPGLWCWWPLLLSVLLQQPERAQSGPGPSTDPGLNLYLSEEEVRRLIGLDAELYYIRNDIINHYALSFNLLVPSETNSLHFTWHAKSKVEYKLGFQVDNPMAMTMPLTNISMQGEVPSSLTVFRVDLYCSGKMDSEVLFLMQLNITISSAKNITVLNFKRRKMCYRKLEDIKVPVLQDKNNTRIHFDPVNVAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRVELDDSMSDSSSSQGLSQPSTQTTQYLRADTPNNATPVTSSSGYPTLRIEKNDLKSVTLQEAKAKVKDIAISRERVTLKDVLQEGTFGRIFHGILVDEKDPNKEKAVFVKTVKDQASEVQITMMLTESCKLRGLHHRNLLPIGHVCTEDGEKPMVLLPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDESLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNKEFSSAGDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHSALGAYV
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin.
Subcellular Localization:
Endomembrane system; Single-pass membrane protein. Peroxisome membrane.
Sequence:
MCYCSSQEVNKSTCNPGTTEESATVQPTQQSEPVQPPRDALVSTAIHFLENPRVQASPLSQKRAFLLKKGLTNEEIDSAIERSRAAPVANVSDVSGPFPPPLPPPVPMGMLPHALQPPELSMWTYMRHVSSSVVLIGVACYGAYYLYKRFLEPYLRGEELSKEQNRLVQVQEQLDALTSAIGQLREAVASLESSVGEDRRNRGRTETLDASKQDSTLSDLKSEVLSVKALLLSRNQFPSTPKVTPLAVTIPAWQLSAGGDSKKENGTASGDSEEEHETNEQKDDKVTSNGQVAANAAAALV
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
Subcellular Localization:
Chromosome. Cytoplasm.
Sequence:
MAPQSRYDDDDQGIFMNKSTMLANFEEWIKMATDNKINSRNSWNFALIDYFHDLNVLKDAEDNINFQKASATLDGCVKIYSSRVDSVANETGKLLSGLAERRNKEAAEGADGGADGGEREDEVEIDPESGMPIARDLLDVGKRRRNYNRVLETTLVEFSTIRAKELDQELHIDPLFKKTLAAFDEGGAKSLLLNTLNADNDLRVVFDATSADAEGGRSAASAGMATAEAGGETETPSCTEDEESEASDRLEPSLRADDEEMLDAETSICPSDAPLAAELSVISETDSVSSIVVEDEILALGIQFLNFDLINAAELCPSMSQLKAAVQDGDHAKIFMDANHKFDNFLTEEDMQEAIPASGDCADGDDFGYVLPGQDDEESYNASNDDMQHGDSLGPDESPSNMVASVMDQDLLAYFDDVFTKSWRGREHWKVHNYKNKLLKHKEKLSLDPKQRADSAASSNDDKEPRKKARKDNTVDFFDLESSAEETIFAASKTSIELPEKHREDPSHYLLPDDYHFSAAKVTKLFIKPKQHMSFFAQRKRPSVAAAPRLPPVGPIEPSAPPQLADENFWADRYKEQELQDSQLQDASPDTGTAADPTVSDDECVDFNQAFDADGLDDDDHDAVALTPLAKPDAKVPYSRTAKKVDVRRLKNNLWKALSARLAAEKSAAAEESAAAEESAAEESAAPAPRPLCIKFTDIAADIAAMYSDKTRKDLSTSFCFICLLHLANEHGFSISHCDRYDDLNILFDLDAAA
The following text describes a protein:
Function:
Involved in phototaxis. Required for coupling photodetection to the locomotory machinery of slugs. May be essential in the natural environment for the propagation of spores.
Subcellular Localization:
Cytoplasmic vesicle.
Sequence:
MEEDNIVDSKEIENNVEDKKEETPSSSPSPSSSLQQQQEEGGVVKQAVSNLVSSSITLHDDAKLIQVTGKDEPFHFISVPMSVEFLNLEDVFIMQSDAYIFVWCSEQANIKKKAKAVQMAQKLKVEIGCQRAVQVLEIGEEHPTFLFCLGVPKGTKLNVTKEKNDIFQVDEDDEEQVLEPEFFLFKIFTGTDGKPSIKPMEEDEGINQEMLESSACFILDCEHEMYIWLGKGVKKSTKDTLIPVAKKIWTQYDRPEYYGKLKLQPIITWVFDGAESCLFKSKFSKWVEKAQPLQTSYLSLSSKKKEALNFDVSSMHQDKEVPVINIGAASDYSNGKLLVWCSGGGSGNKWNKVEEDDFGIFYSNKSYVCHFIYKPENKNSIRSVIFFWEGLYSNQRNYIGYKFGLYKEIQKKMEGLKSDDPVEYRISQNKEPQEFINLFGTELLVLNEELALKPMIFQVRANRGTQLFPDPDSCNAKLLNSLDSFVFLFPNKYIIVWHGKVSTEHQRELAADLFTFLPPEYEAGVKEFDQGKESDNFWKIIGGNSNDIVINTFINENKEEKEKEEEEKEEEEEEEEEEEEEEEEEKDNNKTTTIIKHLRPKKIKLFLCTDNSGIFKADQINPFSQVDLNSQECVLLDVYHKVFLWKGSKSTDQKLNDTQDLAKQYIETANDQRPSDCSVELVEQYNESPLFKSYFHSWKVTPPKVFIDPIISYKQKLAERLQKEKEDLEKLKQQQEQEQEQQQKENNKIVEEVKEEVKEEDVKEEVKEEEVKEEEVKEEEVKEVAKEETKEEIKEEVNDEATEVKEVNQVEEEVKEEEVKEEVKVEVKEEEVKGEAKEEEVKEEEVKEEEVKEEVKEVKEEVKEEVKQDKEEEVNEEIKEETKEEETKEDDNKEDEKVNEENETVNEENEVGIIVSPPSEKVDEANSSSTISSPENEGSVSVKDKRKSNEPITPSVVSSSGDLLFAYEPYHGPPIHSSNSPKQGRKGGRKSHGKNQPQHKKNHSVDQSPLSSPIIPNKSLNLDIDNQSFDLNSINNNNSVEVLDGASSPLSFSSSSINSNSTHNTPSKKNKNKNKKKHNRSSSLTHA
The following text describes a protein:
Function:
Sugar isomerase that catalyzes the reversible isomerization of D-lyxose to D-xylulose. Shows weak activity with D-mannose and L-ribose.
Sequence:
MRGTEWREARDRVAEMFRKAGIALTPSELEKVEVADFGLGNLAVQGLQLVTYINTDRYCAKELALFPHQTCPEHLHPPVGGDPGKMETFRCRWGKVFLYVEGEPAASVQAAVPPGSEAYYTVFHEIVLTPGEQYTIPPGTKHWFQGGPEGAIVSEFSSTSRDEFDIFTDPKVERMPVIEFDD
The following text describes a protein:
Function:
This protein is essential for plasmid partition. It ensures the proper distribution of newly replicated plasmids to daughter cells during cell division. ParA is trans-acting.
Sequence:
MSDSSQLHKVAQRANRMLNVLTEQVQLQKDELHANEFYQVYAKAALAKLPLLTRANVDYAVSEMEEKGYVFDKRPAGSSMKYAMSIQNIIDIYEHRGVPKYRDRYSEAYVIFISNLKGGVSKTVSTVSLAHAMRAHPHLLMEDLRILVIDLDPQSSATMFLSHKHSIGIVNATSAQAMLQNVSREELLEEFIVPSVVPGVDVMPASIDDAFIASDWRELCNEHLPGQNIHAVLKENVIDKLKSDYDFILVDSGPHLDAFLKNALASANILFTPLPPATVDFHSSLKYVARLPELVKLISDEGCECQLATNIGFMSKLSNKADHKYCHSLAKEVFGGDMLDVFLPRLDGFERCGESFDTVISANPATYVGSADALKNARIAAEDFAKAVFDRIEFIRSN
The following text describes a protein:
Function:
Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated.
Subcellular Localization:
Cytoplasm, cytosol. Early endosome membrane.
Sequence:
MMNRFRKWLYKPKDNVLNIINQIMDACIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELESMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMRDALRHFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFTIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVELPVRADAPAPPALAPAEPRRADAELACSVQNDDQELEQLSRLVHSAGDAMASLLSPPSAGPSPAHRPGAAASPRGRASPGRAQLPPAGDEEEGRVFFMEDVDGAAEAPGGGVDPQETGQGREAGVGSPASAKREDSSNNNSVEGAALRAAAPTSCSCLDSRPHLDGWEAGAEHAETAELIAHRTGGMKLSATVIFNPKSPASLDSALTHPGVPGNGVPAAAEGTAGGPHRLSATATNCLLNSCVCCAGCAGTGEDAAAQSLRGKCGSGGVIRSAKVGAKGSAAGPLEALPAGGPDPAPSEDAPGRPEPEAPASDKCLAHSSGPPGDAADRLCGGVDGSHQQEEAPQEQPPPPAGPSGSTAGPCSPDTSSPESARVAVREEMRSRFRGSRDLIHRLFVCISGVADQLQTNYASDLRSILKTLFQVMATKPETDDKEKLKKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDLEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSDKAGI
The following text describes a protein:
Function:
Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.
Sequence:
MKIIFNADDFGISPGAVYGILESYKRGVVKSTTLLANSPAFDLAVEVAKENPGLDIGAHLTLTFGSPVLQGLETLTDDDGRFRRNYTSLENGLADVDMNEVERELTAQIEKILDAGITISHFDTHHSIEPLIYPVQHKLAEKYGVSIRRHSDVSDFGAIKTPDLFATEFYADGVSFETIKKLVQKHIGTNDVVEVMTHPAFIDETLREISSYVEPRIKEVSILTSRELQAYLGQQEVEIISFRDL
The following text describes a protein:
Function:
Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
Subcellular Localization:
Secreted.
Sequence:
MRLLGLVVAVLVLAAAASVPVSKRSPRYCGRDFLRFVARTCARSKRSWQADERRRWEGPYHLPGLTKHYDRTGYHVDRLPFQGRRPEDVHTVTRKQAGLAYYCCERGCSHEDIASIC
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MANLNQAIIRHQPTSVQFGVYTDDEVRQRSVCEISSSVAYDALNTPLPRGLYDPLLGPTAGGGGGASAYCITCGNVQNLCPGHFGHIELCVPVYHPLFFPKLLLFMKMKCLACHHFRLSKRACRVFCTKLHLVDVGRMGEAMGLDEEMAALASKASVGGGDGKMSKQVKQEMMSSAAVLIDELLDQKMALRPPDGQSAEEVTHTMHERAVRRKILKEFQQACTKCLKCANCNAFSNKIRHDQFNKMFQVALPARNAKVSDVSREDFPANTKGKKKKKSTSSSTVDEEIDPTGGPISRKATVSTTKNIEASKQDNFMHALEVEAQCRLTWNNEPFLCSKFFGWGKGYTLFFLRAVPVPPSRFRPPVIMGNMTVEHSQNFYLSKVLELNARIRSAFATIHELTQEEADLKNTDKGQANMLEIWVDLQTTVNCFMDSTRDPKGTANNAPNGIRQLLEKKEGIFRKHMMGKRVNFACRSVISPDPYIGTNEIGLPLYFAKTLTFPTPVTALNIAEMRKLVQRGPLQYPGAVWVEFPNGQRIDLSKMKEGNRHAIAARLLADNGVVKVGRQLRDGDMVLMNRQPTLHKPGIMAHRVRVLFSPTQNTLRMHYANCNTYNADYDGDEMNCHFPQSYLAAAESQFIAGTDLQFIVPTDGSPLRGLIQDHVDAGVKLTCMNTFIEREVYQQLLFAALGSLPGLELIRSDANIELLPPAIRKPKELWTGKQVISTLLNHLRKGNDRDEDPSFNFPGLSMERKAKTPATAFGASWNEHMVIVRDGDLVQGILDKAAFGASEFSLVHAVYEAYGPSRAGLLLNALGRLFTAYIQYYTGHSCRMEDLILTPDADEKRRQLVKVESDGGKVEIPPVAQNPKSKQPLKPHEKATVASKIGELLSGGDGKENAAALDGFMQSQVNPLASDIIKICLPDGLAVPFPENTFGLMTTTGAKGSMVNQSQVSCSLGQQALEGRRVPRMSSGRTLPSFAPYDPNPRADGFITDRFLTGVRPQEYYFHCMAGREGLVDTAVKTSRSGYLQRCLIKHLEELKVSYDHTVRDGEGGVVQFVYGEDGIDPTKAAHLDCESRTFQFLARNHESLKKRYPALPGSTLDIAVKDSRRAQETTPAESFHCEIIKPGVPDPIVSDTARENGAHRLGSSGACVSEHVANLASNAMKDTGVKKALENSGLSKEGFSALVAAKYSSALAHPGEAVGSIAAQSIGEPSTQMTLNTFHLAGAGANVTLGIPRLREIIMTASKELKTPTMSIPLSESVSDREALRLTRYFSKVSLMDLLASHGGITVREVLEKGAGSNWERCYYVTLKLHPAERINEAFGLRLEDIAAVVTKTFIPKLARVMKAEMKRNETNEGYASIEVIGGASTDFMESDVSGGESSKSKASKRPKDDEYDDEVANDEDGVTGTRFGHRKEMTSYGDMDDDDKYIAKRSAKDDSDEDEDNRLPAVITEGEESDDELESKSSNTARISRSKNSIILDPLRVDPSTCPLLMVGLVERAAETTIVRARPKINEGFVNNEEGRGRCLQTAGCNFEEMWSLDEGVVDHNKLVSNDIWGIRCAYGVEAARMSIADQIRGVFAVYGISVDPRHLSLIADFMTYDGEYKPMNRIGMADISSTFLQMSFESTSVFMVDAALHKRNDPMMSPSANIVMGHPIRHGTGAFECIAKA
The following text describes a protein:
Function:
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MALRAWRRRQLPALLALCALLCRLQDTLQITPLCASERHYKHLGRCCNKCEPGKYMFSKCTATSESICLPCGPDEYLDTWNEEEKCLLHKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSEDCHCCRRNAECAPGFGAQHPVQLNKDTVCKPCLAGYFSNTSSSTEKCKPWTNCTILGETEARHGTDKSDVVCSSSLPSTKPPNEPQTYLPSLIILFLFISVALVAAVIFGVYYRKKGKALTANLWHWVNEACGRLSGNKESSGNNFSCTRMEASSQREVGEGVLLLTLEEKVFSEDMCCPDGGGACGGACAGGGLSAQGQDARVLTLVSEITGDPFRQIPTEDEYVDRAPQTPDSILFLTQPGSTSTPPFPEPLEVGENDSLSQCFTGTESLVDSESCHFAEPAFRTDWVPTSSEKYLLEEMEGGNGPHLAASPSSTDGCAGCRSPAGEDWEPPVDSPQSGPLPQCAYGMGLPPEAADRAEAGGQPLDGAEVKLPSSMRGGPGSGGPSNDQPPASGNVTGNSNSTFISSGQVMNFKGDIIVVYVSQNSQEGPAGTGGGAGEPVGRPVQEESPPCCDSFAGLGPRFPDTCAGLEVGPALQKRGTPGHKASRPVQEQGEAKARASETRR
The following text describes a protein:
Function:
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
Subcellular Localization:
Nucleus.
Sequence:
MEVGGPALKSHLGSATMRRGGWRKRAENDGWENWGGYMAAKVQKLEEQFRSDAALQKDGTSTAIFSGVSIYVNGYTDPSADELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVVRPEWIVESIKAGRLLPSIPYQLYTKQPGVPKGLNFNTICKPEDPLPGPSNRAKQLNQRVNHILKKFETGNEVKINGLSRWNEEDPSADLPSTELEQVLPGRKPNGVQHPRDSTAIFNGHTHSSNGALKTQDCSGPSGRRVASRLSPSPAPAPEEEKMAAGSVDLRHRALEQLPQSNGNSEMVWNPHRTMNNSFPSSPLHSHAKINGAQHSTLQGPSSTKSTSAIPSLSKAVPSTPPRPSDGNFISNFYSRSRLHHLSTWKCELTEFVNTLQRQSSGVFPGREKLKKLKAGRSAFVVTDTGNVSVLSSPRHQSCIMHVDMDCFFVSVGIRNRPDLKGKPVAVTSHRGGGRAPLRPGTNPQLEWQYYQNKIQKGKAVDKVPDLLDSSMWESQDSALTNGIDLDGTVLSKAEIASCSYEARQVGIKNGMFFGQAKKLCPNLQAVPYDFHAYKEVSRTMYETLASYTHNIEAVSCDEALVDITEILAETRLTPDEFADALRTEIKDQTKCTASVGMGSNILLARLATRKAKPDGQYHLKPEEVDDFIRGQLVTNLPGVGRSMESKLASLGIKTCGDLQYMTMSKLQKEFGPKTGQMLYRFCRGLDDRPVRTEKERKSVSAEINYGIRFTQPKEAEAFLLRLSEEIQRRLEAAGMKGRRLTLKIMVRKAGAPVEPAKFGGHGICDNIARTVILDQATDSAKIIGKATLNMFHTMKVNISDMRGVGILVNQLVPISKSSPGDATHPAAQSVRFPGGAHSVLDLFQVQKAKKPAEEEHKEVFVAAMDLEISSASRTFLPSFTTHLTSGLSPVMSKTEPAAKWNGLHSPVSVKSRLNFSIEVPSPSQLDQSVFEALPADLREQIEQMHAMQQGEAPGEKKKEPLNGCHAGILPQPVGTVLLQIPELQESSSDAGVSVIALPALSQVDPEVFAALPPELQEELKAAYDQRQRQLENPPNQQPASTSGLKNPLLQLKQASVKNKKRNRKTNNAVSPVKAAQSPLKNRPLGSPAKSTAVPCGSPQKLIDGFLKQDGTTASKPQTEPVASTSTVPSPTASQPRPPAPNLAGAVEFNDVKTLLREWITTISDPMEEDILQVVKYCTDLIEEKDLEKLDLVIKYMKRLMQQSVESVWNMAFDFILDNVQVVLQQTYGSTLKVI
The following text describes a protein:
Function:
Immune regulatory cytokine.
Subcellular Localization:
Secreted.
Sequence:
MWVSCILRCGLLFVTLSLAIAKHKQSSFAERCYPRGTLSQAVDTLYVKAASLRATIPEDRIKNIRLLKKKTKKLFMISQGFQEQLLSFFMEDVFGQLQLQVCKEMHFVEDFHSLRQKLSRCISCASSAREMKSITRMKRTFYEIGKKGIYKAISELDILLSWIKQFLESIK
The following text describes a protein:
Function:
Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus membrane.
Sequence:
MPYLLISTQIRMEVGPTMVGDEQSDPELMQHLGASKRRALGNNFYEYYVDDPPRIVLDKLERRGFRVLSMTGVGQTLVWCLHKE
The following text describes a protein:
Function:
Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTLTEFLNMQSPLVKRLYVGGLGHTVSKVELQERFGKFGNVTDTEILTRKDEQGNPTKTFAYINIKISEKELKKCISVLNKTKWKGGTLQIEMAKESFLHRLARERQEANENKEKPSENSMINVLESMKKSEIVDFNVKAVPGTEVPNHKDWVVSKFGRVLPILHLKSQHKKKIIKYDPSKYCHNLKKLDQDNCKTVPISQLTWHLEEGDENISKKRQGQFPVTNKPPKKKMKVQNRDSLNNVSLNSSCQFSSDASHTVPTKLVQNHTSNARKQCKEQTRSQKPTTGLTLHRNANSLFENDIDSEEEIRALIAREREVHNINTDVEPEDNMEIVGDNFELKYATHWSLQRTSDSKKAFTEALKTPENKSDYDSDDTDEIIAVNKIPNKKEKNGTPKTPKVVKQGKVKGPKGGISIHATVSESFGSKILISDKAKAEGKAVPGKMSDFKANPEKNSISSPSEDGGSSSHLDTSGSEGDDDYETMTQNCYRLDLTLEDLGRLAFEHSESAEEDAESNQSDNQCKTNIFQDNSISNIPKASTSTPKQCICPEDILSALLEEENSDEDNRKKKKGNVKVQPFRGIGSLSGELTKDKLDTHGSKAKKAASGPLDVETLKSVPKSLSKKLNGKSVSLKKTDSKQISLQVISGVSPDSSTSSADNSEAQSSDGTSASESEDLGSLKAASEERIKDDKIKGSCLTLDKNLNKSEDMFLDSTKGTSKLDETEKRLQDNAKRLTALQERKKEWEMQKKLIQGALTNLEIQSTNKKKHIVFDSDSENEADVQEDSNEGSSGNLGKEFTTKTSGKLFESSEDESVASDEDGDRFKIKPQFEGKAGEKLMHLQSRFGTDERFRMDARFLESDSEQEDESKNLKIDEEEGLAVEKKKNLEILKNLLCIDVEPPKPSKLTSNAKKFKDMNALRYDPTREDHTVFEKKPKTPEKESKAKKKKKREEAQKLPEVSKEIFYEVAVDLKEVFGSTKQDERTEEISWDKREDVEETPLADTETFNFTAGNNAPEGSSGFAFSFFGAEENRSPVNKEPYTIETIKPTKVAWQEDPRFQDSSSEDEESATVQNDDVKERPLTRLQSNVRFFFFSQDDDRLKEGPKLFCKSSDLDEDRDNWESRRQMLLEDCRKKHKDARRKVKVKQ
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins under precise conditions, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins. Strictly required for import of TIM23 in some conditions, when a low membrane potential exists in the mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion intermembrane space. Note=Import into inner membrane protein requires TIM5 function.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM8 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable).
Sequence:
MSSLSTSDLASLDDTSKKEIATFLEGENSKQKVQMSIHQFTNICFKKCVESVNDSNLSSQEEQCLSNCVNRFLDTNIRIVNGLQNTR
The following text describes a protein:
Function:
Plays a major role in assembly, budding and uncoating of virion after membrane fusion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates replication. Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons. Inhibits the integrated stress response (ISR) in the infected cell by blocking the formation of stress granules (By similarity).
Miscellaneous:
MISCELLANEOUS: Most abundant protein in the virion.
Subcellular Localization:
Virion membrane; Peripheral membrane protein. Host endomembrane system; Peripheral membrane protein. Host cytoplasm.
Domain:
Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Matrix protein contains one L domain: a PPXY motif which potentially interacts with the WW domain 3 of NEDD4 E3 ubiquitin ligase (Potential).
Sequence:
MNLLRKIVKNRRDEDTQKSSPASAPLDDDDLWLPPPEYVPLKELTGKKNMRNFCINGRVKVCSPNGYSFRILRHILKSFDEIYSGNHRMIGLVKVVIGLALSGSPVPEGLNWVYKLRRTFIFQWADSRGPLEGEELEYSQEITWDDDTEFVGLQIRVIAKQCHIQGRVWCINMNPRACQLWSDMSLQTQRSEEDKDSSLLLE
The following text describes a protein:
Function:
Accepts electrons from ETF and reduces ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MLKIISRTKWNPLKNRHHNPPHFFNSSTSSHQFHPQSDFSSSGYSPEASNSFNSLLFLSHNRFFSPGYSVNRGNFKNLSWIGGGLLWNSSLVGSKRSFCSGSGRESMEYDVVIVGAGPAGLSAAIRLKQLCVEKDVDLSVCVVEKGAEVGAHILSGNVFESRALDELLPEWKQEQAPIDTPVLSDKFWLLTKSRAFSLPSPFDNKGNYVISLSQLVRWMATKAEELGVEIYPGFAASEILYNTNKEVVGIATNDMGISKDGSKKHNFQRGVELKGRVTLLSEGCRGSLSEKIIEEYNLRNKGKAQHQTYALGIKEVWEIDASKHQPGFVLHTLGWPLDYKTYGGSFLYHMKDNLVSIGLVVALDYQNPYLNPYEEFQKLKHHPAIKPMLEGGSCIQYGARTLNEGGFQSIPYPVFPGGAIIGCSAGFLNVPKIKGTHTAMKSGMLAAESAFGLLHEGLMMDRYWDKLQTSWIWEELYKARNYRPAFEYGLVPGLTMSALEHYILRGKSPWTLKHGKFDHEATNVAKLHSPIHYPKPDGVISFDVPTSLYRSNTNHDHDQPTHLRLKDPLIPDQVNLPEYAGPESRYCPARVYEYLPDDSGDMKLQINAQNCLHCKACDIKDPKQNINWTVPEGGGGPGYSVM
The following text describes a protein:
Function:
Probable transcription factor. Binds to the DNA sequence motif 5'-[TA]TGTT[TG]T[TG][ATG]TT-3'. Regulates sexual dimorphism in the gonad, promoting male gonadal cell fates in chromosomally (XO) male animals, yet plays a role in gonadogenesis in both sexes; probably acts downstream of terminal regulator of sex determination tra-1, to control early gonadogenesis. Positively modulates expression of homeobox protein egl-5, probably acting indirectly, during early gonadal development.
Subcellular Localization:
Nucleus.
Sequence:
MTRHQTHLPFHIVQEGNSIDKPPYSYVALIAMAIDASPDKRMTLNQIYKFIEAKFPYYRDADAKRKQGWQNSIRHNLSLNDCFVKKARDGQSCANDRKGNYWQMVADNAPQFDNGNFKRRRVKRLGIGKMGYANTTETTETGTILQQQLPFFNGLKWPQNIQTMDPFQFFKFQYPNSITDSANTSQINNSSSSSSSFDTSIYTSAFPIPTSHFDTNLVAPSQPPPVVSDVEVVPSDTVKEEVLVDMKPLIPGISSTTFLTSLQMTDPRSIEQQQLLSTASNMYPNAFMPPYTNWSCQPTTTFTGLSFDDPSLYGYGQQFPASS
The following text describes a protein:
Function:
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MMKSVLFAYVVAVVISLAVCKPSDHEGSSRVKQETKLSDQAHFDEHGKHNPDYDHDAFLGEEEAKKFTNLSPEESKEKLGQLFDRVDLNKNGSISESELSAWIEIQTNSVLYGELDRLFKAHNMNGDDLLTWAEYNHTTYSGLPLEKLITMQEDKTLDFRKKVRQDKARWSLADQNRDEALDREEYMAFEWPREKLHMKDVAIAETIEDIDKDGDGYVNFDEFMKDLWDGQGEMPDWVEAERKGFAEYRDKDGDGKLNHEEVGDWIMPTHYDPIESEAKHLMYETDENKDNELTKEEMILHFKLFVGSRVTNFGELRHDEF
The following text describes a protein:
Function:
May be involved in sterol transfer between intracellular membranes.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Localizes to puncta in the cell periphery representing cortical endoplasmic reticulum (cER)-plasma membrane (PM) membrane contact sites.
Domain:
The VASt domains bind sterols.
Sequence:
MTRDSKKKHHWGTAFLRTIGVKRKHKKDRNFLNNTTGENVSTTASAERFRRVGGNPDIPSLLKPETFTESPAKGSQKAAASSLAHSQGVFNIPIVIDPMETNRLEKTNTNLTAGSLKGRFQDGNSNSNSVPSLSVQALEKEKLQSGKREGSSNQAEEKTPDGHDEHTAFETFLSFAHNAVSHIPKINVQDADNGTISRNEPKDRKKNSSNISGALSENSTNNKNTSSTKESDGPFLKNLDNILAASKSSTPSNQQLNTTEAGSKSKPSSLSRLAFGNLKGHIHSNSHSSSNAISGDDTSLDDTRKMTDDMARKVVFEPIRHSHDKPTPGVGNLKLEHFDDSQATLEGLEAMSAESLPEADHLDSRGPVQQSNLERKTVPSKWSVVSSSTTDGVKPRRRAKSMISAMADKQNTSSDVLQDCKKRLSFNSSNGLTNNDPEYEDREPREMSKKFLNRRSFSPGSISMGMKVLPSTALKYSLNKVKNSTDIASTIIPRPSMSNGRPSSGLRRSSSKSFSSTPVNIIEPSEENGRQSSIRIKGVEYASEKKDAEFHAIFKDSGVSPNERLILDHSCALSRDILLQGRMYISDQHIGFYSNILGWVSTVFIPFKTIVQIEKRATAGIFPNGIVIDTLHTKYTFASFTSRDATYDLITEVWNQIILGKRFRSNSNNTNSSSNSISDDENDDYDDDYDDYGDDDDDLYDNSNNISDSTDMTSSVSIGKPEDLPMPLQTDTPYGTGIPPLGPKIHSPTETVYKPAPNEKLVNESTIHASLGRVVNILFGKDVSYIMAILKAQKNSDISPIPVLVDSPTVSEGKKRDYSYVKTTPGAIGPGKTKCMITETIQHFNLEEYVQVLQTTKTPDVPSGNSFYVRTVYLLSWANNNETKLKLYVSVEWTGKSLIKSPIEKGTFDGVTDATKILVEELGNILTRSATKRKRSSKENTVTVSTLPKMEPSSHAPTEPDIQKDKDDSIIRENENIPAPLGTVVQLLFGSNTEYMQKVITRDKNNVNVETIPKFTPSLVEGGSRHYEYTKKLNNSIGPKQTKCLLTESIEHMDINNYVLVTQTTKTPDVPSGSNFAVESKIFLFWGQHDTTNMTVITKINWTSKSFLKGAIEKGSVEGQKVSVDYMLSELRDIISRAKSKKPVKKVMKSHDKHRPFHSKVEQKSSESRKSDDNKDILTHILDFVQNNFSSEIFMNKLLSPQKLFLILGLTIMLFWSPRLHVFQEKNNLQIIKPGRLLIDGQEYNYVPSFGTLYNSYENAISSKKKRENVNYARDKSPIVGRESDIWDWISNRGSAISPRGRAMLRNDDEHKLQQLSESIKITEMQLNHMKTMLDNIERDANDLS
The following text describes a protein:
Function:
Involved in ribosomal large subunit assembly.
Subcellular Localization:
Nucleus.
Sequence:
MDVSHVLDEYTASNTTAVLPRAAPVHTDPALLAAFDASPLDPAAYADRERHLLQLTLTSTHALVAALFALPTTPSSAGPVTAFPPPTTLLPREKPLPTPKAPTKWERFAKEKGISHRKKEKDVWDEERQEWVPRWGRFGKNKDKEDQWLHEVKPGDEADQDPGKTARGERKARIAQNTKQHSANLAVASASVTAARATAASERAARKEELNRNMLISKTSTASLGKFDNKIEGEPKARGMKRKFDANIPGGSEGTEKERQLSVLKRVERGETNKSKRGGEGVQGGLNVRKALRFSGEGGKLRPKTTGKKGKRK
The following text describes a protein:
Function:
Required for melanocyte differentiation.
Sequence:
LFLHNWTVSSHKPRRLFLNISPCTLNRSGAIEKPVVWLCIRNNGVTNLLDLAKSDKEESEGCPCFRDRRSLEGLSAFGSLEELILDNNLLGNDLVLPGLPRLHTLTLNKNQITDLECLLDHLAKVTPALEYLSLLGNVACPNELVSLEKDEEDYKRYRCFVLHKLPNLKFLDARKVTRQEREEALVRGSFMKVVKPKVSCQLSGLHQGFMSCPTGYSLSTEDLFLCLECRRDLQPGFYPWICCWPSKT
The following text describes a protein:
Function:
Transcription factor that binds a CNS-specific regulatory element of the Dopa decarboxylase (Ddc) gene. Also interacts with sequences adjacent to other transcription units, including Ultrabithorax (Ubx) and engrailed (en). Activity in vivo may be required only at high levels transiently to activate the expression of Ddc in the CNS.
Subcellular Localization:
Nucleus.
Sequence:
MSTSTATTSVITSNELSLSGHAHGHGHAHQLHQHTHSRLGVGVGVGILSDASLSPIQQGSGGHSGGGNTNSSPLAPNGVPLLTTMHRSPDSPQPELATMTNVNVLDLHTDNSKLYDKEAVFIYETPKVVMPADGGGGNNSDEGHAIDARIAAQMGNQAQQQQQQQQQTEHQPLAKIEFDENQIIRVVGPNGEQQQIISREIINGEHHILSRNEAGEHILTRIVSDPSKLMPNDNAVATAMYNQAQKMNNDHGQAVYQTSPLPLDASVLHYSGGNDSNVIKTEADIYEDHKKHAAAAAAAAGGGSIIYTTSDPNGVNVKQLPHLTVPQKLDPDLYQADKHIDLIYNDGSKTVIYSTTDQKSLEIYSGGDIGSLVSDGQVVVQAGLPYATTTGAGGQPVYIVADGALPAGVEEHLQSGKLNGQTTPIDVSGLSQNEIQGFLLGSHPSSSATVSTTGVVSTTTISHHQQQQQQQQQQQQQQQQQHQQQQQHPGDIVSAAGVGSTGSIVSSAAQQQQQQQLISIKREPEDLRKDPKNGNIAGAATANGPGSVITQKILHVDAPTASEADRPSTPSSSINSTENTESDSQSVSGSESGSPGARTTATLEMYATTGGTQIYLQTSHPSTASGAGGGAGPAGAAGGGGVSMQAQSPSPGPYITANDYGMYTASRLPPGPPPTSTTTFIAEPSYYREYFAPDGQGGYVPASTRSLYGDVDVSVSQPGGVVTYEGRFAGSVPPPATTTVLTSVHHHQQQQQQQQQHQQQQQQQQHHQQQQHHSQDGKSNGGATPLYAKAITAAGLTVDLPSPDSGIGTDAITPRDQTNIQQSFDYTELCQPGTLIDANGSIPVSVNSIQQRTAVHGSQNSPTTSLVDTSTNGSTRSRPWHDFGRQNDADKIQIPKIFTNVGFRYHLESPISSSQRREDDRITYINKGQFYGITLEYVHDAEKPIKNTTVKSVIMLMFREEKSPEDEIKAWQFWHSRQHSVKQRILDADTKNSVGLVGCIEEVSHNAIAVYWNPLESSAKINIAVQCLSTDFSSQKGVKGLPLHVQIDTFEDPRDTAVFHRGYCQIKVFCDKGAERKTRDEERRAAKRKMTATGRKKLDELYHPVTDRSEFYGMQDFAKPPVLFSPAEDMEKVGQLGIGAATGMTFNPLSNGNSNSNSHSSLQSFYGHETDSPDLKGASPFLLHGQKVATPTLKFHNHFPPDMQTDKKDHILDQNMLTSTPLTDFGPPMKRGRMTPPTSERVMLYVRQENEEVYTPLHVVPPTTIGLLNAIENKYKISTTSINNIYRTNKKGITAKIDDDMISFYCNEDIFLLEVQQIEDDLYDVTLTELPNQ