lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Promotes dissociation of capu from the barbed end of actin filaments. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for localization of determinants within the developing oocyte to the posterior pole and to the dorsal anterior corner. Links Rho family signaling and Jnk function to the actin cytoskeleton.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Punctate spots in perinuclear region and cytoplasm.
Domain:
Binds to actin monomers via the WH2 domain; The Spir-box targets binding to intracellular membrane structures.
Sequence:
MTEHQAEEQADTPPTKVKATPTPTPSGKFKDAKEDAFLSTSPDSANGDAQHKLPADQLAMSSSAHPQQAGQARPLILQAFHRCSSPEQCVTLHDILDSFKAPLSEDQAWALIHQFAGLYHQVAVQAHTCAADYEAALPTGFELHFHRDGSVHFSGPDQLTPKEQLQQEQIPLPPQHDVIVDQPDHSASSSGDSSVINRAFDNSNHHHHHQHHHPPLVVSHRKIISELAEIVYTALDYNLPEDEECQVSQELENLFNFMTADETDDDCIDEGIDEGDKRWDDESEEERNDTKELEHIIETCRNHIKTTLPENHYRAVCRALVTETIELRVFLQQVLNNEAGAEKLIKASESSATTQQELAKLGFNDWARFWVQVIDELRRGVRLKKSNHERTPIEYELTPYEILMGDIRAKKYQLRKVMVNGDIPPRVKKDAHAMILEFIRSRPPLKKASDRQLGPPRMCEPSPREQLMESIRKGKELKQITPPEAPTLRERVLPSANSTLSRSRQRLIKVDFSKFQDDDLFYDENSISSSHSTAATHQHHPHFAEMHRCSQPKMPPYPFGGYMVPSQARQDCRETASLMRPRRTMEPAKQVPPPEEPSFTKDEYHKFYDTALESYDLATQCESRRASLRRHTIVGCQSNLDETHSMPPTRPESRQSDDVSKETPKRSPAEQTHPSDEGSSTSSLGPWNKSFMDKQTWMERGDDRLSVTLAEIVHIRSVMTKAELEGLPMDVRVKEDVEKRRVCFLCLRTRFSFFGPWGIQCKLCQRTVCAKCYTKMRIPSEHFRNVPLVLISPSLLSSPASSSTPSPSHHAQQAHSSSTGNIMDDQFPKSLIERLLRSESDRKTRSTVGSAPSSPKHQRSNMSTPGISVGPGASSSSAAATGQAVEALHDQATMSSSYSAAMRPSGVHQQQKQHYNNAMSRSMEGPRSLPVHSPAYRPLSNNSTLERKSRFSRGFNLFSSGSHLAQTQEQKENLRGEQVTVCNDCQGLVNEITSSVKQKRSSARNRTIQNLTLDLTPVWK
The following text describes a protein:
Function:
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
Miscellaneous:
MISCELLANEOUS: Several bitter taste receptors are expressed in a single taste receptor cell.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTDKVQTTLLFLAIGEFSVGILGNAFIGLVNCMDWVKKRKIASIDLILTSLAISRICLLCVILLDCFMLVLYPDVYATGKQMRIIDFFWTLTNHLSIWFATCLSIYYFFKIANFFHPLFLWMKWRIDRVISWILLGCMVLSVFINLPATENLNADFRRCVKAKRKTNLTWSCRVTKAQHASTKLFLNLVTLLPFSVCLMSFFLLILSLWRHIRRMQLSATGCRDPSTEAHVRALKAVISFLLLFIAYYLSFLIATSSYFIPETELAVIFGEFIALIYPSSHSFILILGNSKLRRASLKVLWTVMSILKGRKFQQHKQI
The following text describes a protein:
Function:
Adapter protein able to interact with different proteins and involved in different biological processes.
Subcellular Localization:
Nucleus.
Sequence:
MLDEHFCDCIGEFLETSFHCILYIRGVYPSCLFSKSIKYDIPVPISRSDLLTRYISNSIDSLKPHFLKDTIEKISLTILNKYDKPIEKFIFEISSLNNTTNNKNKNNNNNNNNSDDDETFNYYINIQKQNYTSNNNNNNNNNINNNNNKPNLLQLEASFKAYIIKILMTTDSFYSEQNFYKTQQSSSSSSSLKTSGGGDGNGFISNSDGVIHFNEIDNETYQQIKSNQKNKKEDNDDNNNGDKDLKFTIHVHTKPTTSNIGLNTNLSNVILNINPLESPRRTNTTINQITPVWISTTEKDSEIENSYIIPLNSNITDGKTTIRTFTEQSITK
The following text describes a protein:
Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MQGIKMASPVIRAACKRSLHQSAVRAITIPFLPTLPQNPGGVKGDVNEANPVPPANKMHGSLHWNIERAFAVAAVPLVGLPLVAGSGVSTLMDSLLASVMLGHCYIGFQACIIDYIPQRVYGKFHQYAMYLLAFGSLLSGVGIYKMESEGYGICGAVAAVWSGKAAREEKA
The following text describes a protein:
Function:
Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MINNWLAVGLLVVSGILAFNWKRKHPYGQTVEIGEKPENGGRIRRNSACADHLISFLEDDEIYTLYDSLVKSCKKYGERKCFGERKKDSNGNLGKFEWISYNTYLERCEYIQQGLCELGLKPKSKVGIFSKNRLEWLIVHSASFIQSYCVVSFYETLGVESLSYVTEHAEIGLAFCSAETLQKTLDIAKGVKVLKTIICFDSIDKEHYNIAKELGVTLYTYDEIMKKGKEANGKHKHTPPTPDTLSTIMYTSGTTGPPKGVMITHKNLTSVVCAVSDFIKVYDTDVHYSYLPYAHVLERVVILAAFHFGAAIGIFSGDISNILVEVKLLSPTLFIGVPRVFERIKTNVFKEISKKPALLRTLFNGAYNLKYLSIQHGFKLPIIEKVLDLVFFSKIKQALGGKVRVILSGSAPLSFDTEVFLRVVMCCCVLQGYGASEGCGGDACKRLDDESVGTIGPPFASNEIKLVDVPELGYDSNGEVQTGEVCLRGPSISSGYYKDEEKTREEFKDGWFHTGDIGRWNRDGSLSIVDRKKNIFKLSQGEYVAVEKIETIVVKSEYVEQVCIYGDSQKSCVIAIIHPHPESCSEWAGSKKTDKDIKEICKNQDFIKVVLDDIIKNCKKSGLHGFEIPKAIHLTPEAFSDQNNLLTPSFKLKRHEIKKYFEDEIKKLYSKLD
The following text describes a protein:
Function:
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space.
Sequence:
MDSLSLSKHLLLPLFLDFFNYFLAEAHMKPCKKPLSVTSQGAREQPTWITIMHLFNLIKGDLHIYQWVKGFTVLPYTSPNGNSTAHPETTSPPCPQYTEDCTELSSQSKWSGHFSRCPKTYRQYCIKGKCRFVTSENMPACICDFGYTGARCEYLDLFYLKGDRRHYIVIGLIVAMMALIILIVGICICTHHWQKTQRRKRKEKESEGQNNDSATKMEETNFV
The following text describes a protein:
Function:
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role DNA in replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MNLETMRIHSKAPLPGGIQDRNEKNRPSLKSLKADNRLEKSKYKPLWGKIFYLDLPSITICEKLQKDIKELGGRVEEFLSKDISYFVSNKKEAKYAQTLGRVSPVPSPESAYTAETTSPHPSHDGSSFKSQDRVCLSRGKLLAEKAVKDHDFIPANSILSNALSWGVKILHIDDIRYYIEQKKKALSALKKSSASGKDAGKKAGPGIQKTRTGRLKKPFLKVEDVNRCYRPFYLQLPSLPCINYFLQKPCSPFDIEKSSSVQKQAQPKLRINMDGDKCGTPVQLQLKEKRKKGYCECCLQKYEDLETHLLSEKHRNFAQSNQYQVVDDIVSQLVFDFVEYGRDTPQKKRIRYSVGSLSSVSANVLKNTAPKEKPLLEPNFQKDVGESSGHLLKPNSQYEETQKPEEKHGFASEPTTYSSAGLKGCDRKPVSMFNASEPDPEQEYAQLPLRDSTPEHQVTEGRNDGEQRVDPAPGVSQSCGQVSHLSTESNLPQPQLAADITQLSAKDLQEKGFHVVIGHASDLVALNTSKEQLTMKARTPPCSPQEPHECDTENMENLPCGKIQRKVRMLLGQQKANAEPSAELDKKRTEYLPAHEDRTCGSPVQSLLDLFQTSEEKSEFLGFTGYTENSGICDVLDIWEEENSSTLLSTFFSSPSTSAFVGF
The following text describes a protein:
Function:
Transcription repressor that negatively regulates root hair growth by directly binding RSL4 promoter and repressing RSL4 expression. Required for the synthesis of seed coat mucilage.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing DF1 exhibit very short root hairs.
Subcellular Localization:
Nucleus.
Sequence:
MMQLGGGTPTTTAAATTVTTATAPPPQSNNNDSAATEAAAAAVGAFEVSEEMHDRGFGGNRWPRQETLALLKIRSDMGIAFRDASVKGPLWEEVSRKMAEHGYIRNAKKCKEKFENVYKYHKRTKEGRTGKSEGKTYRFFDQLEALESQSTTSLHHHQQQTPLRPQQNNNNNNNNNNNSSIFSTPPPVTTVMPTLPSSSIPPYTQQINVPSFPNISGDFLSDNSTSSSSSYSTSSDMEMGGGTATTRKKRKRKWKVFFERLMKQVVDKQEELQRKFLEAVEKREHERLVREESWRVQEIARINREHEILAQERSMSAAKDAAVMAFLQKLSEKQPNQPQPQPQPQQVRPSMQLNNNNQQQPPQRSPPPQPPAPLPQPIQAVVSTLDTTKTDNGGDQNMTPAASASSSRWPKVEIEALIKLRTNLDSKYQENGPKGPLWEEISAGMRRLGFNRNSKRCKEKWENINKYFKKVKESNKKRPEDSKTCPYFHQLDALYRERNKFHSNNNIAASSSSSGLVKPDNSVPLMVQPEQQWPPAVTTATTTPAAAQPDQQSQPSEQNFDDEEGTDEEYDDEDEEEENEEEEGGEFELVPSNNNNNKTTNNL
The following text describes a protein:
Function:
May be involved in iron transport and iron homeostasis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLTVVCLLSPSVLLVTDLRVGTDVHLDHVATDGDGDEGQGRGVVEPHCPVPFVKLNTDILEAESLNLLAEATVVLSEEEQHAPFQLLRLTRLVYTLLNCKCSGAALKFCLAFCHCPDSSKPFASCCDGFLHQSGYNCWWSLGWQTYGPFSKNAAAQLLSAAMIIHAHSVQPTSFSTLLLRPWFVVLVSAWAIERLCVVALGVANERDWIVLVLSFRTLSVPLTFPSTGKPVFKGLEAIKLGWKEYLGQPVLLASLAWVFLYFNIVLMPGSLLTAFLTQRGLHPSIIGGFSGMCALMGVAATFVPSTLVKQFGILKAGAVGLVFQALLLSMAVAVYWSGTISHQSPLLTFLFLIDTCHNVVGAQILQTGIPSSKANLIGMTEIAVASLVESIMLGHCCLFYQWLLNPTDEQKSLFFL
The following text describes a protein:
Function:
Member of the two-component regulatory system NarS/NarL involved in gene expression during aerobic nitrate metabolism. Plays therefore a crucial role in anaerobic survival of mycobacteria in host. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of NarL. In turn, NarL binds to the upstream promoter regions of target genes to regulate their expression during aerobic nitrate metabolism.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPSYGNLGRLGGRHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMVVGTSRSEWPQQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGRLEPFAFTAVDVLILTGFQLLSTDGIYPLLIMILLPVLVGLDVSTRRAAVVLACTLVGFAVAVLGDPVMLRAIGWPETIFRFALYAFLCATALMVVRIEERHTRSVAGLSALRAELLAQTMTASEVLQRRIAEAIHDGPLQDVLAARQELIELDAVTPGDERVGRALAGLQSASERLRQATFELHPAVLEQVGLGPAVKQLAASTAQRSGIKISTDIDYPIRSGIDPIVFGVVRELLSNVVRHSGATTASVRLGITDEKCVLDVADDGVGVTGDTMARRLGEGHIGLASHRARVDAAGGVLVFLATPRGTHVCVELPLKR
The following text describes a protein:
Function:
Catalyzes the stereoinversion of LL-2,6-diaminopimelate (L,L-DAP) to meso-diaminopimelate (meso-DAP), a precursor of L-lysine.
Subcellular Localization:
Cytoplasm.
Sequence:
MEFTKMHALGNDYIVINEFDGEKVKEEEKAEFSRKICRRGFSVGADGVIFIQKPTSDEYDVRFRIFNSDGSEAEMCGNGIRCFSKYVYERIMKKNPLKVETKGGLRVSEMEIEGDEVKKIKVYMGVPKFKLKDIPMVVDGYKEDDEFLNGELKLKNPYLPKVKLSVVNVGNPHAVIFVEDNNIDLDFVREHLDVIGKEIEHHEAFPERINVHFVKVLNPNEIRIVTWERGAGYTTACGTGTTASVIMAHKLGKTNNRVLAHLDGGDLEIEIKDDGVYMIGDAVMVYDAKLINIGW
The following text describes a protein:
Function:
As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking. Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MRAVLTWRDKAEQCIYDLAFKPDGTQLILAAGNRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSIIIWTSKLEGILKYTHNDSIQCVSYNPVTHQLASCSSSDFGLWSPEQKSVSKHKSNSKITCCSWTNDGQYLALGMSNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSREEHNDILAVADWGQKLSFYQLSGKQIGKDRPLNFDPCCISYFTKGEYILVGGSDKQVSLFTKDGVRLGTVGEQNSWVWTCRVKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCRELVKKIAIYKNRLAIQLPEKILIYELYSDDSADMHYRVKEKIVKKFECNLLVVCADHIILCQEKRLQCLSFSGVREREWQMESLIRYIKVIGGPAGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRNKLAVVDENDTCLVYDIHTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHQQKLQGFVVGYNGSKIFCLHVFSMSAVEVPQAFTRVQDLRYLELISTIEERKKRGESNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALNMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNINEPKAAVEMYISAGEHAKAIEISGSHGWVDMLIDIARKLDKAEREPLLMCARYFKKLDSPGYAAETYLKIGDLKSLVQLYVDTKRWDEAFALGEKHPEFKDDIYVPYAQWLAENDRFEEAQKAFHKAGRQGEAVRVLEQLTHNAVVESRFNDAAYYYWMLSMQCLDMAQDPAQKDVMLDKFHHFQHLAELYHGYQTIHRYTEEPFSFDLPETLFNISKFLLHSLTKATPLGISKVNTLFTLAKQSKALGAYKLARHAYDKLRGLQIPARIQKSIELGTLTIRSKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYEVLHLVEFYLEEGITDEEAVALIDLEAPRHKREGKWQETSSNNSQTLRLDETMDSIGEDDPFTAKLSFEQGGSEFVPVVVSRSVLRSMSRRDVLIKRWPPPLQWQYFRSLLPDASITMCPSCFQMFHSEDYELLVLQHACCPYCRRRIDDTGP
The following text describes a protein:
Function:
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular Localization:
Cell membrane.
Sequence:
METLLGVSLVILWLQLARVNSQQGEEDPQALSIQEGENATMNCSYKTSINNLQWYRQNSGRGLVHLILIRSNEREKHSGRLRVTLDTSKKSSSLLITASRAADTASYFCATD
The following text describes a protein:
Function:
Serine-type endopeptidase that cleaves Gly-Gly bonds in the polyglycine linker of host plant class IV chitinases to disrupt their chitin-binding, and thereby plays a role in lowering the defense responses of the host to the fungus. Degrades Z.mays Endochitinase A (CHIA). Has low proteolytic activity on Z.mays Endochitinase B (CHIB).
Subcellular Localization:
Secreted.
Sequence:
MYTSRSLFSTLASCLSLATLVASSPTTNQNLPSSKRDATVEQNVFFDINGKEVETRIAKLKAEGYRPTSLNIHGTPTDAKYAGIWIKQDGNPYETIVGANKTTYDAWLDQWKASGYVSTQVSATGPASNAVFAGVMEKIPSIRNWTQICGTSSPYAYLNATGDAPIVITGVSLYGTPTERQYCVLGHEDTDNHQQTVWFPTSSSQDYKTIEPAETTKRFWRPVFIDSSEDKLLASIFDDTSVGNWTVRTDLTASQLQSEITAQKANNMHPIHISGAGSTETQYVVIFTEQATPLERNWHAVGDITGFPDNARVKRDLDEILQKFMKRNSVRQAQVSASINGTVIASRAYTWAESNRAIVEPSDKFLLGSVSKAFTYAAVDHLVSTGVVNLTDHIYPLLGYTKPADPRSLNITIQHLLDHTGGFDRGMSPDIGFIFTTVAQSLNQSTPATLRQLIEYVLAKPLDFEPGTRSVYSNYGTLLLGYLIANKTGETYMSYLEKNVLKGLDVEMYTTPGADHTNDRIVQETKFTSISALTPLSEKRVANVYGGDGAVKEAAVSSFALKASADTVSRFIGKHAAYGLGPRQLFMYRDGTVAGARALAYSMAKLDWAITLNTREYLDENAWNTLVFTDLYQLWGALDSALPL
The following text describes a protein:
Function:
Mediates water and glycerol transport across cell membranes. Permeable to selected sugar alcohols of up to five carbons and urea. Permeable to methylamine/methylammonium.
Miscellaneous:
MISCELLANEOUS: Can transport hydroxyurea, an antineoplastic agent with inhibitory effects on parasite proliferation.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Note=Localizes to a multivesicular structure that exhibits similarities to the plant-like vacuole.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
MDQFVFSGGSEGGGELGGDRERDSLTPELGRFEHLIFNMQKYFCEFFAALVIVSAVAFGLAKEGGAQAAPLSITSTIFALITLFKDISGAHFNPAVSCTIYMTDPRFTLVDLLCYVAAQLIGGTVGAFIGYGIMGKALDILPLDPGMSASRQLFHEVIPTMVMIYAVLVLVFGYGVMWELTVPFVVGACVLAGAFAGATMNPAVTFGIFISNICTKNTNIDVAALLVTLFGPFLGAMFAFLGYVGTHAYHNPVPLRFLNFRGL
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Late endosome membrane.
Sequence:
MNQNQPITNVCIVAERNACPPRYNILDRTIENEDADFWKDGLFKSKIRRYLCFTREPSQNQLNEVITDMALIGVKDPVPVGYTALKETADTREQALKKHNLCIRYIPKTSTSSAISDILLCRDNSYKERMYTLMGELNGINVAFKLSTIHIPTNRPAPPPPVQRVNTTAVNTPAPMNDTIQRNHTQQQQHNVMSGIEGVEWKLHDRFTQTKAGMNSKTALNIEIRTRSELIDLCAYDFTKEKSILYSC
The following text describes a protein:
Function:
Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.
Subcellular Localization:
Mitochondrion.
Sequence:
MSRLIINKSNSRICNTIVKNYLIQTKYTLQQQQHQQQQQQQQYVRSYCSLQQPKPSKPNMIEIVTHFFDKVKNKSFIIENYLNNPIPEQQQQLNKNIKINNTDKDNDTLEQIQLLDPLNNLGKRKGNEIFKVVENDLSNMTHNIMKTITDGVSANSTYSPSPSKKTHPILSSISSYYFELKGKRIRPTIVLLLSKALSSTVHGSQLKLAEIVEMIHTASLVHDDVIDEASTRRDVISINHSYTNKLAILCGDYLLARASVVLSTIRNPDVTECMSTALAELVEGEFMQAKSNGVVSFDNYLQKTYLKTGSLITNSCRSAAILSGADSNIINISTEFGKNLGLAFQIVDDLLDYTGSAEECGKATSVDLTLGLATAPVLYATQEFPQLEKLIKRKFSEIGDVEEAKRLVALSKGIEKTRNLAIEYCNRAIQSLLKLPQSESRDLLITLSHIVVTRTK
The following text describes a protein:
Function:
Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
Atypical domain architecture: contains 2 receiver domains.
Sequence:
MSNYLNANSTENNNNNNNNNNNNNNNINNNFNTTDFKIVGNFNTPPIGSNNNNNNNNNSISTQSLQTINECNSGGEQSPKIKTNNNSYNTPVSSSTSTTGTNTTPMKSTPIHNSLQNIFKNANRSNLNNNNNNNNNNNNNNNNNNNNNNNNNSGCGSGSLNSVNNNNNNNNNNNNNSNNNNSNSNSNSNNNNNSNSNNNNNNSNSNAYPLKYYQHPQQSCSNLDSFENLSPLRQSSTLLNFSSNNNNNNNNNNNNNNNNSNNNSSNNNNKNNSSKNKVGGGNNKNNGGDDSAQFISSDNKYNTVGNETHHHHHHQLHNHRHSNVQGSSSPIKSSPKLISSQSLGNIFSQISPNIALTTNISPHGSPFSSSSSSRKSSSSPSFLNQNNQNNPNNQNNQNNSTSPHEKSFLNNSNDSFDYNDNSKRLRNRLTRNTGYSSTGSIGNSSSSSFYNNNNENSNIYSKIKHTRSSSGGNKPSPKYFQTSQAIYTPPYPQPYPQPPQLPPPSSSSSLSKENDNVDNNNTNNNNNNNNNNNNNNNNNNNESFFSSKGTMNLIHISLLSVLAFYIFLMVSKKFLFRVFQWNNNINSLFILIFSFHFIFSSILMFLLVVLLKMKKYSHSISQSARESLRNSRVIPSLLNFFLSDYIFLGLVLSGLVNILQVNLFFNPKDPLLNLDSISNISTAIEFLVVGIVLNFSHIPKKMYNSRYSEFRVSSSISPYFQDESYNVNNIINNDNKNKINDKSDNSNSITNNNNINNNIDNNNNSSSNTKINNDLNFDNNIKNNDINNNITNNNNNNNNNNNNNNNTNNNNNNNNNNSNNNNNNNNNNSNKNNNTNSNNNNNNSSNNNNTNNNKINDNKNNNNNNNNNNNNNNNNNNNNNNEEDDEEEKNDWSYSFQIFFTRIFLCLSITYTLIVLRLNYDPLNQFLQQSSSFGSGANGNSGGGNVNTIISPVQFQAPLATLLHFIQLVLLLVNYNRFRTNRFFSLILSTIFIEVSSWETFGLNSRLFESYIFEALLIRRWIRACSVGFPIVGIILDIYSGWMSINQSIKSIDQQNIMIVNRFNYLCSNVKKQEELTQYNSQFYIESMNQFKRLVQNTGSIISLIYDTDVQPNQEAYLSKFSSSYEQLSKLTKECLFYSEIKQLKRNDVENLSFVVSNLLEDLISTPSIRTQFEEKEIDLFYLIDKDVPLSLVGDSQKIKQILLKLITNSIKATYEGEVYIRVSLSSNLGVLKQQPIHHHRHHHRHHHHHHHHHHHHIIDDDDYDDDNDDDNNTEDSSSCCNIDELSDKIKDNQDENLELKKSNNDKIIENKENQENNNNNNNNNNNNNNNNNNNNNNSNNNTNININTNNNNDSNNNNCINNDLKNNNNNSNNNVNNNNNNINDSNNNNNSNNNNINNNINNNINNNNNIKKKKKKNEFTVYFSVIDSGSGIDPYSTNLLFQPFSLSSYNVNSTNTDGEFGLGLAICKQLSNLMNGEIKYETEMEKGSVFELQVPMKCDSISSITSSMNSTTNTTNHYPRIMNNQSSKFFANSKWGEGLKILVIDDNPNIGKVIAMHLEPFGFKVFQRTTFQSAIYFFNERNGDFNLILLDPLIPSLVIDEIKQMKQDSSNIIKNPPLVIMCTAKLRKSLNVDNVHYLYKPIKREQLTVLSQLLPNTSTINPIYSNQNLNNSGSSNGGGGGGGGGGGGGGGGGSGSSNIDFNKTKLGGSNISTGIGNSGLINSNNIPTPVNTPSNIIPNLLSCQSLLTSLNNANIPQLTNDIGITNNNINNNSLMFTTPNSTLSNNGITGLDNNSNNDTGSIDNNSNISTNIDNNNDYFIRNNGIPPQNDMNTYNNYVLNHQQGVLPKSLSVPSTPLSYNMLPTNLNINAKRSSLQPLNENSVLPTNLTPPILSASPQSLLPMGNDINSILPNTQQSQIDLQSQIELQPLLQSTIIRNDRGGDILPDSTLEGQITNLSGNNSTISINPPLPETNNNTTTTTTTTQPKKSPILTSSNGSDKSEGSTGSNRSKSRISFLNSSNSGLLKNNLGEDIYCKGDQSEGIPIPKSERTSDSSSSSSSSDSHGQDDHSYRLEDFSISSPSSQSPLLDLSGTSGTSGTTNLANSGINSGSGSGGGDIINQNQLITSNQLFQQQLQQQQQPQQQQPPGTPTISPSSSFPLLPIPRDIINSSGASSGIKVKSSTSIPDYVQVSPRRFSGSSTGSGSSVASPQLLSTSNQLNNNINNLNLNSNNNNNNNNNNNNNNNTNNDNNNNNDNNYNVNILLVEDNLVNAKIAMTVLRKHNFRVELSKNGQLAMERIKQSHSSFDLILMDIHMPVMDGITCSKLTRKFETEHGLKHLPIIALTADATTGHKNLCLEAGCNEFMSKPLDYALLISLLKKLVFNKDQ
The following text describes a protein:
Function:
Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia. Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MPPSGLRAAAALVPLLAVLLAPPRPAAAMSTCKTLDMELVKRRRIEAIRGQILSKLRLDSPPAQSEVPPGPLPDAVLALYNSTRDRVVPESVPEAETDYYAKEVTRVLMLPQNPDVEKSPHSLYFHFNTSQLQEAVPNPALLSRAELRLMKTKSAEEQHVELYQKHGNGSWRYLTSQRVRASQSMEWLSFDVTNVVHEWLSSKEKTETFRLSAHCSCDQKDTQLHMDVSGLNNLRGDMGVIHNQNRPFLLLMATPLDRAQNLHSSRRRRALDTDYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDNQYSKVLALYNQHNPGASVNPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSLQVQLRPPPHSRRSPGRPEPPPFPPPPQLAPYEREKERPGLGGSCGI
The following text describes a protein:
Function:
Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1.
Subcellular Localization:
Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MRTKMADLDSPPKLSGVQPPSEGVGGGRCSEISAELIRSLTELQELEAVYERLCGEEKVVERELDALLEQQNSIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRNEDYEQAAAHIHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNSTTEKIEPRELDPILTEVTLMNARSELYLRFLRKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYVTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKLSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAIKPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGPNSGPLTWRLTPAEVRQVLALRIDFRSEDIKRLRL
The following text describes a protein:
Function:
Transcription factor which promotes the expression of heat stress-inducible genes by contributing to the formation of a heat stress-specific transcriptional complex with NF-Y subunits (e.g. NF-YA2 and NF-YB3) and DREB2A at the promoter of target genes, thus promoting heat tolerance. Together with the glyceraldehyde-3-phosphate dehydrogenase (GAPC), enhances heat tolerance.
Subcellular Localization:
Nucleus.
Sequence:
MVSSKKPKEKKARSDVVVNKASGRSKRSSGSRTKKTSNKVNIVKKKPEIYEISESSSSDSVEEAIRGDEAKKSNGVVSKRGNGKSVGIPTKTSKNREEDDGGAEDAKIKFPMNRIRRIMRSDNSAPQIMQDAVFLVNKATEMFIERFSEEAYDSSVKDKKKFIHYKHLSSVVSNDQRYEFLADSVPEKLKAEAALEEWERGMTDAG
The following text describes a protein:
Function:
Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure (Probable). Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step (Probable).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria (By similarity). Located in a unique membrane in the hepatocyte, which is not recognizable as any known subcellular structure.
Sequence:
MSWLLGYVDPTEPSFVAAVLTIVFNPLFWNVVARWEQRTRKLSRAFGSPYLACYSLGSIILLLNILRSHCFTQAMMSQPKMEGLDSHTIYFLGLALLGWGLVFVLSSFYALGFTGTFLGDYFGILKESRVTTFPFSVLDNPMYWGSTANYLGWALMHASPTGLLLTVLVALVYVVALLFEEPFTAEIYRRKATRLHKRS