lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in nucleus positioning in guard cells.
Subcellular Localization:
Nucleus membrane; Single-pass membrane protein.
Domain:
The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to the SUN proteins.
Sequence:
MGLNLNPILRQELANLDKDTESRKSAMKALKSYVKDLDSKAIPGFLAQVFETKETNSLSGEYTISLYEILARVHGPNIVPQIDTIMSTIVKTLASSAGSFPLQQACSKVIPAIARYGIDPTTTEDKKRVIIHSLCKPLTDSLLASQESLTSGAALCLKALVDSDNWRFASDEMVNRVCQNVVVALDSNSNQTHLQMGLVMSLAKHNPLIVEAYARLLIHTGLRILGFGVSEGNSQKRLSAVQMLNFLMKCLDPRSIYSEVELIIKEMERCQSDQMAYVRGAAYEAMMTSKRIAAELESKMEKGCRSVTGSNFSRRNCSSIVPDYSLSPESQTLGSFSGYDSPVESSPISHTSCNSEFDRRSVNRKLWRRDENGGVVDISLKDGLFSRVTKGSTTVSDSPLVPYDTCENGDEFEGFLMESLRNTTPSPQRQRSRRINAEDFNIFSTPRKLISSLQYPDDVDLDHSDIQSPILRGEREKTIGSRKNPKLRKQFPTMVETMSSTITVSEDTAQTQMITGKKKKKKMSYAKLVIAISFVVVALFATVILMVNQDDDVGYYTVPT
The following text describes a protein:
Function:
Acts predominantly in the phot1 pathway. Involved in the leaf positioning and also in the phot2 pathway controlling the leaf flattening. Component of the network that modulates the very low-fluence response (VLFR) branch of phyA signaling. Regulates phytochrome-mediated photomorphogenesis and hypocotyl phototropism. May act by controlling auxin homeostasis.
Miscellaneous:
MISCELLANEOUS: PKS1, PKS2 and/or PKS4 are essential for phototropism but not for inhibition of gravitropism under long-term blue light irradiation.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MVTLTSSSSTPNVSFDFMMNNNNNSNNLYGPFSSSSTSFSYLTSKEDALTQKNLMSGITNDVLGINKKASEDLEISVFGAEKYFNGDMDSDHSPRLVSPLPDPEVPIERIFVGPKQSSKNSSETPSLRSESSWNSQSLLLQSKYVEKKKNIKKNSSCNSYFQEKDMSSNHKVSNKKSFLATLGCRCVCSNWSSVDVVDDKRRSSGLKKIKTQLSFSGDLSSEMKIHQQQQEAMLEQRKSLEIFGSPLIEKRIIQKKFPWEYSSSAKKEEHGFSVKYEEEEDGSVSDVSTDLFEIESLTGKANPFLARQGSSDPDSPDGYAPSEVSIQWSVVTASVADFSVMSECATSPVKKNRSFQIPRIPIMAKSNREIAPQRRKSSSSGLLMGCKSHKSVRVSGDSYTSMNRTPSYVPRFPVEANPTSTETRRRISSSSVSHTQSPFLYT
The following text describes a protein:
Function:
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MRISKKNLLIYSLLIIISLIVLYPFFFMIMNSFKTGSEIINAPNALPKNFSFNGYIQAFYSLNLGRIFLNTLFISVTVTLVNTLLSAMVAYAIVKMNLPGREFWIKLILTSMMVPAVLFTIPTYMMLYSWGWVNTFQALIVPGTISAYNIFLLVQFLKQVDNAYLEAARIDGAGEFTIFFKVVLPMIRPALATVAILTFMGSWNDFMGPLLYVRDDSLMTLQLALFKFVNDIPTDNLEQLWAMTTMIAVPVVLVFFFLQRNFIKAFTGIGVK
The following text describes a protein:
Function:
Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces.
Sequence:
MEGGFQIEGRSQGCGDFSNTMPLGCMSCFLPAVFSVTNMRFILLPCLWASLAGVLLAENNKIVQLRLVNGTNHCSGRVEVLYGQQWGTVCDDNWDLIDAEVVCRQLGCGTALSAAFSAYFGRGSDPIWLDDVMCKGTEAALSECTAKPWGKHDCGHGEDAGVVCSGFAKPAPLRLVDGSTHCSGRIEVFYGQHWGTVCDDGWDLADAEVVCRQLGCGKALSAPHGAHFGQGSDPIWLDDVSCTGTEAGLSTCKASAWGSHNCGHGEDAGVVCAGFAELLPVWLVNGSNFCSGRVEVFHEQQWGTVCDDSWDLTDAQVVCRQLGCGKAISTPGSARFGQGTGTIWLDDMNCAGSETALTECPAKPWGDHNCNHGEDAGVVCSGAAEPAPIRLVNGPSHCAGRVEVFHDRQWGTVCDDNWDKAEANVVCRQLGCGAALSAPGSARFGQGSDPIWMDDVNCVGTEAALSQCQFRGWGSHNCKHGEDAGVVCSDIPRAVPLRLINGPSRCSGRVEVFYGHQWGTVCDDNWDISDAEVVCQQLGCGRALSTATSASFGEGSGPIWLDDVNCTGAETSLSKCETSLWGAHNCNHGEDAGVVCLGVPEPAPVRLVNGSNFCSGRVEVFHEQQWGTVCDDSWDLTDAQVVCRQLGCGEAISTPGSARFGQGTGKIWLDDVNCAGSETALTECQVRPWGEHNCNHGEDAGVVCSGIAEPAPIRLVNGPNLCTGRVEVFHDHQWGTVCDDNWDKAEANVVCRQLGCGAALSAPGSARFGQGSDPIWMDDVSCVGTEAALSQCQFRGWGSHNCKHGEDAGVVCSGTAEAAPLRLVNGPSRCAGRVEVLHSQQWGTVCDDSWDLSDAAVVCQQLGCGTAMSAPGSAYFGQGYGRIWLDDVKCSSRESALSECAARPWGVHNCNHGEDAGVICSGGI
The following text describes a protein:
Function:
Transcription factor required for yeast cell adherence to silicone substrate.
Subcellular Localization:
Nucleus.
Sequence:
MSLPSPPVLKTTIIQLNKELDPEDDNNNYEILTNDYNNYGSSNTSDAGSIPTSPIIEVSGTTKSGSGLPNKKKRRRSTANIDSEELAKRKNETKQLHSIIEKRRRIKINREFEALKYLIPACRNCNTGSSGGSATPTSSTKKASTNSNNNGNKIDGMYKLTILKSSVEYILYLHHIIQKQHQLLSSISAKDTNGGILAEKLKAFEDFDIDFAKVPLNVNQYRNIDKDFNFKDLMQDLDGRSVNTESPETIIEENEPVSETSSTNNTTTLHYSNSSVLPSRTSSIVSSRQSSSLPTPELTPILSILNKYSTSNNQLNNRKNSNPISPQTVCIKSQNPSPFTMPMKSSLSTSIVNSPSSSSSLSGSKSYMAGNNAVNTVKFSLPDPVVNPNSTLNDNIPRKGLISGIPEEEEEEKINKGSANTETVNSGSASSDENNDNDRGVLLKLTDQDVSKTLLALRKSSIDSLLN
The following text describes a protein:
Function:
Involved in the biosynthesis of terminal alkyne-containing amino acids such as L-beta-ethynylserine, that are produced as antibiotics by S.cattleya. Catalyzes the ATP-dependent ligation of L-propargylglycine to L-glutamate to form the dipeptide L-gamma-glutamyl-L-propargylglycine. Is selective for L-propargylglycine over norvaline, allylglycine and the standard proteinogenic amino acids, except L-cysteine which can be used as a substrate to a lesser extent.
Sequence:
MYGAGVVTRMNEAERFHMTDPGSTKILIYAFNYADRMLEEVPYLRYSAERSLCFLGDLRDPGTRLVVITSEAVDPATLDYHLRDVFRFDEPALADVRRRLTLLTPASRAARPLDSLVLEDEALVETLRRAVAERPAGTIVDFSASPATDELGRRTGATPEEGDHAFVARWGSKSGGKEICLRAGVAVPGGTSEVLRSEAEVVEAIHRLSCGTAAARRAMVKLDAITWAASIGNVLIDRDKLRHTGDLVGSAEVIRLPAEEFRRELAEQGAIVEEFLEEITDSPSGLGHIERDGTVRVVACHDQVLSGGQYWGCRFPADERWRPEITDAVRRTGEVLSGLGHRGAFGVDFVVAGERGLLAVEINLRKVGPSHVVRYAEALVGARVGADGMLRGADGRPVYYTHGRLLEPETLGKLNPRTAVERLRAEGLLYRHDTGEGVALHVLGALNACGFVELTALARSPEAADGYSRAAQALLTGPYPSA
The following text describes a protein:
Function:
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
Sequence:
MIYQAKTLQVKQLANGIAELSFCAPASVNKLDLHTLESLDKALDALAADSSVKGLLLSSDKEAFIVGADITEFLGLFAKPEAELDEWLQFANRIFNKLEDLPFPTLSALKGHTLGGGCECVLATDFRIGDATTSIGLPETKLGIMPGFGGTVRLPRLIGADSAMEIITQGKACRAEEALKVGLLDAIVDSDKLIDSAITTLTQAIEEKLDWQKRRQQKTSALTLSKLEAMMSFTMAKGMVAQVAGKHYPAPMTSVVTIEEAARLPRDAALDIERKHFIKLAKSTEAQALVGIFLNDQYIKGLAKQSAKAASQDTQHAAVLGAGIMGGGIAYQSALKGVPVLMKDIAPHSLELGMTEAAKLLNKQLERGKIDGFKMAGILASITPSLHYAGIDQADVIVEAVVENPKVKAAVLSEVEGLVDTETILTSNTSTIPINLLAKSLKRPQNFCGMHFFNPVHRMPLVEIIRGEHTSEDTINRVVAYAAKMGKSPIVVNDCPGFFVNRVLFPYFAGFSLLMRDGANFTEIDKVMERQFGWPMGPAYLLDVVGIDTAHHAQAVMAEGFPTRMAKSGREAIDALYEAKKFGQKNGSGFYQYTVDKKGKPKKAFSDDVLAILAPVCGAPQSFDPQTLIERTMIPMINEVVLCLEEGIIASAQEADMALVYGLGFPPFRGGVFRYLDTIGIANYVAMAEKYADLGALYQVPQLLKNMAQQGTSFYSAQQVSAL
The following text describes a protein:
Function:
Plays a general role in the hierarchies of gene expression leading to metamorphosis.
Sequence:
MTESKNDTKSWAPKQIWIKDVLKKSGTELLDISKSPAKAVAVKKSPAKDSATTKMVYYSANQLLIKTEQSSQAQFCLQVPPPLTATTTSVGLGVPPSGGQQEHFELLQTPQQRQMQLQLQDQHQQEQQQFVSYQLAIQQHQKQQQQQQHESITNAAPTAAPSAQRIKTEPVGGFPASAAVVSQVRKPSASKPQFKCDQCGMTFGSKSAHTSHTKSHSKNQDLSLNGASGAGVAAPVSTAAIELNDAGLPVGIPKSPTIKPLANVAAGADPYQCNVCQKTFAVPARLIRHYRTHTGERPFECEFCHKLFSVKENLQVHRRIHTKERPYKCDVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPGCGKGFTCSKQLKVHSRTHTGEKPYHCDICFRDFGYNHVLKLHRVQHYGSKCYKCTICDETFKNKKEMEAHIKGHANEVPDDEAEAAAASAAASTSAGSSAGSPSLQGVSSNSESSNHSPPSSPPATKKPRQARQPRVSKTVAATLSIPTSSPLSPSSLSSTYSPSASSMASPPPTSAHYLPVQMEADALSRDSGVSSAQPAHSTYADEEPTDLSMQQVQGQLPESTVDYYQAPPSLLELQPQPAGLTINPALLEAASIARRHDDNDDQVQDEDVHAAAWQMMQLCRGHGSLPPTEQPAPSHQPQVPTLHVSDLAANYDDTHEATVLIEHFKRGDLARHGLHKGYAPVPKYESALPNPDVVRRVEAAIGLRSSTESPERSSSPESDSLMMADRNVMTLPLRKRKHYMNKGDDGQVDSEKASGDGTSAAGGAASVGAGDGPGSKVMRMSSVIQFAKAS
The following text describes a protein:
Function:
Probably involved in the movement of the endonuclease-encoding DNA.
Sequence:
MFYYTYKITNKINNKIYIGVHSTENLDDGYMGSGKLLKRAQDKYGIENFSKEILEYFDDKESMLEAEKNIVTEEFLNRPDVYNLKLGGEGGWDHVNIPGMLNQKKDASLKGAKSFKSRFENDILLQEKYRKIGSNVFKRLWSTPEYREKFLNNSRFLNKHHTPETINKMKESHAKNNHQKGEKNSQFGMMWIHSLDEKVSKRIKKTDPIPEGWFKGRKMKF
The following text describes a protein:
Function:
Divisome-localized glycosyl hydrolase that cleaves peptide-free (denuded) peptidoglycans. Has either glucosaminidase or muramidase activity.
Miscellaneous:
MISCELLANEOUS: Overexpression suppresses the chaining phenotype of the tol-pal mutant.
Subcellular Localization:
Cell outer membrane; Lipid-anchor. Note=Localizes to the divisome.
Sequence:
MDICSRNKKLTIRRPAILVALALLLCSCKSTPPESMVTPPAGSKPPATTQQSSQPMRGIWLATVSRLDWPPVSSVNISNPTSRARVQQQAMIDKLDHLQRLGINTVFFQVKPDGTALWPSKILPWSDLMTGKIGENPGYDPLQFMLDEAHKRGMKVHAWFNPYRVSVNTKPGTIRELNSTLSQQPASVYVQHRDWIRTSGDRFVLDPGIPEVQDWITSIVAEVVSRYPVDGVQFDDYFYTESPGSRLNDNETYRKYGGAFASKADWRRNNTQQLIAKVSHTIKSIKPGVEFGVSPAGVWRNRSHDPLGSDTRGAAAYDESYADTRRWVEQGLLDYIAPQIYWPFSRSAARYDVLAKWWADVVKPTRTRLYIGIAFYKVGEPSKIEPDWMINGGVPELKKQLDLNDAVPEISGTILFREDYLNKPQTQQAVSYLQSRWGS
The following text describes a protein:
Function:
GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2 (By similarity). Controls access of pre-ribosomal RNA intermediates to RCL1 during ribosome biogenesis by binding of rc11 in a GTP-dependent manner and, via its affinity to U3 snoRNA, delivering it to pre-ribosomes (By similarity). GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the bms1-rcl1 complex allowing the interaction of rcl1 with its RNA substrate (By similarity). Required for rcl11 import into the nucleus (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle.
Sequence:
MDEKKGHYAKHSGPKAEKKKLKKVSDGSASNNPKAFAVASAGRMARQAMRTADISQKKLHVPMVDRTPDEAPPPVIVAVMGPPGTGKSTLIKSLVRRYSKYTISQITGPITVVAGKKRRITFLECPNDLSSMIDVAKIADLVLLLIDANFGFEMETMEFLNILAPHGMPRIMGVLTHLDLFKKTSTLREAKKRLKHRFWTELYQGAKLFYLSGVLNGRYPDREILNLSRFISVMKFRPLRWRNQHPYLLADRMEDLTLPVDIEQNPKVGRKITLYGYLHGTNLPKHDASVHIPGVGDFVTSDVSSLEDPCPPPDADKVRRRRLSEKQKLIYGPMADIGGILFDKDRVYIEVPTSNFSKDENSEAGFGERMVMQLQEAQQPLGVDGNSGLQLFSNSDAIDTVDRESSEIDNVGRKTRRQPTGLINQELIKEDEGAFDDSDVNSADENEDVDFTGKIGAINNEDESDNEEVAFADSDSDLGGQFDDEDSNLRWKEGLASKAALAYSQSGKRRRNIQKIFYDESLSPKDAYAEYKGESAKSSESDLVVSDDEEDFFKVSKVANESISSNHEKLMESESDRLSKKWENPQLLAQLKSRFITGSLLDSIEGQEEVSQDDEEGDFEDLEDEENSSDNEMEESSGSSVTAENEESADEVDFQTEREENARKKEELRLRFEEEDRGDPEKKDVDWYTEEKEKIARQLVINREAFEDMDPESRAEIEGYRAGTYVRIVINDVPFEFVEHFDSRYPVVVGGLLPNEQRYGLVQVRIKRHRWHKKILKTNDPLIFSMGWRRFQSIPVYSISDSRTRNRMLKYTPEHMHCFGTFYGPFVAPNSGFCAVQSVANSFAKAGSFRIAATGSVLNIDQSTDIVKKLKLTGVPYKIFKNTAFIKKMFSSPLEVAKFEGANIRTVSGIRGQVKKAVDQEHGHFRATFEDKILMSDIVFLRAWYPVQVRKFCTMVTNLLETDKTEWNGMRLTGEVRHELGLKTPLRPNSQYQEIVRPSRHFNPLKVPASLQAQLPFNSRQKALRPRSKPTYMQKRTVLLNAEERKVRDLLQKVMTLHTDKEAKRKAKKAAEHERYHKRMQKEEQAYIEKKREEKAEWFAQHGKRLRQDGNSSGSGKRSKN
The following text describes a protein:
Function:
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of a methylated derivative of known natural products orthosporin and diaporthin. Within the pathway, aoiF catalyzes the biotransformation of orthosporin to diaporthin but also of diaporthin to the final product, by performing a tandem methylation of the polyketide core. Orthosporin is produced by an oxidoreductase that has still to be identified and that catalyzes the stereospecific reduction of the carbonyl moiety of the hexaketide isocoumarin scaffold produced by the non-reducing polyketide synthase aoiG to generate the S-configured secondary alcohol at C-11.
Sequence:
MEELTRSLVNDVEVLNNHFVSTGHPLPSFDRHTPTVVLPNDASPDAHAARERILDNALRLFQLAAGPSAYLLNLQTGYQYASCVRWLCHFQIFHLVPLEGSIAYADLAVLAKAPEPQLISVVRMAMTNGLFLESPPQHLAHSATSALLRNDADFHDWAVTMSDLSFPTAFAMVEAHERWPNSVEGNQTAYNIAVGSELPFFSHLAEQSDRKRQFAGFMRSMARSQGTDVEKLAEGWDWAALGQACVVDVGGSTGHTSVALARKYPDLNFVVEDLPEVVAEGPGYLSYLDDAQDLKSRIGYRAHSFFDPQPVQDADVYMLRMILHNWSFDDCVRILSRLVQTLKPGARIIIVDIVLPDPGVVSASKERLLRVQDLIMQQVFNSMERYLENWMDIFRKVDERLEVKRIVEPPGSLMSLIELSMAA
The following text describes a protein:
Function:
Binds the 23S rRNA and the E site tRNA.
Sequence:
MAKDGPRIIVKMESSAGTGFYYTTTKNRRNTQAKLELKKYDPVAKKHVVFREKKV
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MSNFGDAFDQPEVDPAAEFLAREQDDLAGLEDEVKPAAISAPVVNGDDPTNSASSFEMVEGFEDGTSIKREEFDDAHLKAENDKLRGVSPSPPPLNREVREEPEKIKKWREEQIKRLEEKDAEEEKKKLELREIARKELEEWYKNHEEAIAKTKAANRNAEKQFVAEDDEIVPGTEWERIAKLCDFNPKAKQGSKDVSRMRSIVLQLKQSPIPINNKA
The following text describes a protein:
Function:
Protease that can cleave T7 RNA polymerase, ferric enterobactin receptor protein (FEP), antimicrobial peptide protamine and other proteins. This protease has a specificity for paired basic residues.
Miscellaneous:
MISCELLANEOUS: Was originally classified as a serine protease, but it seems that OmpT could have a novel catalytic mechanism involving an Asp/His dyad and a pair of Asp; MISCELLANEOUS: Encoded by the cryptic lambdoid prophage DLP12.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MRAKLLGIVLTTPIAISSFASTETLSFTPDNINADISLGTLSGKTKERVYLAEEGGRKVSQLDWKFNNAAIIKGAINWDLMPQISIGAAGWTTLGSRGGNMVDQDWMDSSNPGTWTDESRHPDTQLNYANEFDLNIKGWLLNEPNYRLGLMAGYQESRYSFTARGGSYIYSSEEGFRDDIGSFPNGERAIGYKQRFKMPYIGLTGSYRYEDFELGGTFKYSGWVESSDNDEHYDPGKRITYRSKVKDQNYYSVAVNAGYYVTPNAKVYVEGAWNRVTNKKGNTSLYDHNNNTSDYSKNGAGIENYNFITTAGLKYTF
The following text describes a protein:
Function:
Required for male development. In XO (male) animals, fem-3 directs male differentiation in all tissues. In XX (hermaphrodite) animals, it specifies the first 80 or so germ cells to be sperm. Negatively regulates male development when bound to tra-2. Together with fem-2 associates with the CBC(fem-1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of tra-1.
Sequence:
MEVDPGSDDVEADRETRAQKLKLKRNVKFRAQMRRFDEYCGVTNLTVDDLNWPLISGIPLQRQRLTGATYYDDSLLDQNPWDEFSIDRFLEITSIQLITAGAGYERNDEITRFVFQRTMKTIVTYCNFMYDLARRNGKVQITRFELQDLIHRDEFRFYMYFRQFLPNPDPNCTAFSNHYTSLLHTLYFNIPGMPQFWNNSQMYNYAATRGQRLVQNIAAFYPPEYFWNEDESKYHTTFVVPRGTEFSKFYARRFHEALGMPPLENEIITVLDWLAKLCILEIVYHTTIWCDITGFGGLPRIEHYRLAMENVEDIIFDLAIDDFSISRLQLQISPFEISRYSPLDVSGYYETIKRKKDIEEYQNRFYEVHYSDDVRIMNVYATDCSRKR
The following text describes a protein:
Function:
Participates in transcription elongation, termination and antitermination.
Sequence:
MAKRWYVVHAYSGYEKHVMRSLIERVKLAGMEEEFGEILVPTEEVVEMRNGQKRKSERKFFPGYVLVQMEMNEGTWHLVKDTPRVMGFIGGTADKPAPITDREADAILRRVADSGDKPKPKTLFEPGETVRVIDGPFADFNGVVEEVNYEKSRIQVAVLIFGRSTPVELEFSQVEKV
The following text describes a protein:
Function:
Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis.
Subcellular Localization:
Nucleus.
Sequence:
EVITNEHVVAMMKAAISETQDMPMFEPKMTRSKLKEVVEKGVVIPTWNISPIKKAKEVKKKPPGVWEGHACTGSVTIRVTTRTHRHTDCAEQIASALASQDSVKRPFACRSARRTVEGLSTCAETRPQEQGLIVHRQVEPAARHLRVEVVPMGPPPPPKAPGGPSWPQQPDFSFMEKLHAVEEELEQSPVCMDSYQSLGDNLVACRTRSKRPLKDVPLGLLEAELRAPDITPDMYEMGGQEDNEWQGWLRGLMTSEVENDEEGDDEDDPEYNFLDDIDEPDLEDYRNDRAVRITKKEVNELMEELFETSHRVSVSQFQDELGVPDQDDEGHDDEEEREEEVEQGTPKFNVPQAIRFEEPLANMLTERRRTVKEQLEALQQRRALQESRPEPPAPAPAGPHFLMLPSPTCTLLLNPTQKHQLQQQIQQHVQLLTQVHMLTSTIPVLQSEAVTTRHFLTELQSFAQSTEETRGLVEPGFVSMFRACNLEGALSLLEEFDRTIKPQLTQASPQRPARQRCNTVVRPYPTMPPRLAWLLATRKEFLCPELLPICSLDPAQHPPRVKTIYTRGEDSLIALGLKHFADTEFPHQLVCRYLVRTKTAQQLRMHLREASHCRAPDNELKHFLLTRKVPPLLRACQRVLPTDSRPAVERELARMPAWLQKSLPIIHKAVLDYNSTLEGGEATPGESTPPYVFPPGTQYPPDLPADVTLRLNPYGVRTLKPHSRLWAHGRAKRLALSRPVVLPLDKTPMVLQMPLSTRPVNFNPTVTLTRISEKELEQNACKKASSSITQKPSTTEQLPAGAPCSAGGVKTVQIPVSAPCQAGGAGTGMSVASATPGITVQLRAAPPVSFSRAMVAAGVNPSSQFLQIRPVSRSPSHLQAPLQPLLLTIPTGGSVSLYSLGGASVGGVGSGGAGGMLFPRLVGVAPESGRSPTLKGDIPLQLRTSPLLQCSIPSPESRHPASINPTSLPSPAAPETSPGNLGTNTSEVEGAPQAPLKSAAPQCPEPQQPTAGTTEEMNPTGAVPHLSTNTADDTETCQKVWISTDTGAAQPLSQELQGCTVKSVPQNFSSIMDTKGTPQYSTVNAENKGVLPTPSSDPEGEIEEVEEDREDLGQEEEHEEEMLENNEEEDGGGRPGPRRSETEGEEGERTGQEEDRARVNTTACQVEWGLQGEAGGGGLALSSGTESQGQPGQAGEGGGGGGGGGGGGEQEGQRGGGADQEEEEDFDDLTQDEDEEEVMSSASEESVLSVPELQETMEKLTWLASERRMCPEGDSEEDNSQNSQNSQEENSEEEEEVGPRKGEEAGDGDASKMIGQGAPQGAGPLETSDKCAGRGRGRGRTPSRSLRRSRRRERDSKDTSKLLLLYDDNILENDPMRESKDIAFAQAYLNRVREALQGYPGKVEEFLGVLYEFERGREQRSAVELFSQLRAVLTDWPDLLRDFAAFLLPEQALECGLFAEQQAFERSRRFLRQLEICFGENSSQYQKIVKALQVGPELSPAGVEELKVQMASLLKGHSHLEGEFWVFFDELRPPPSRPGQFEEAAWPEEGEGCAEGGFEEVTLPDLEEEEESHKIPPITGRGKRRKEMGSHGNEKECDWPEAAKDCPCPCHDSAHDAKLRRHKRKGCPHCHVAKRGHENLNAESSAALLRSAGNIHFCCSVCPTLNVSHDFTLHLNYILVARDNLSPHLSPSLSLSLCPSPFESLCLRLLLHASISADSSALRPFALGGGVCLSDSLPLRPPRLSRGLCLVRRCGATPPVRPISRRAGLPRPAGSGVRPWDCGEGGAPREEVEEGEAERDKDSGGGSPSPKKSRTDAGAAVATETEAWEEGGCRDPQGAPRTPLPCCSAPPHTQGEPLGGQSPSLSGAPLRMSSGSDSTVCAKNISLTPSGEKVILWNREADRVILTTCQQQGASQATFQAISAQLGNKTTSEVSRRFRDLMRLFHTAARQLSSEDEASAAEQQSA
The following text describes a protein:
Function:
Controls the rotational direction of flagella during chemotaxis.
Subcellular Localization:
Cell inner membrane. Cell membrane; Single-pass membrane protein.
Sequence:
MLKRYVVQIMLALSFIVPFHSHAEEKSAVPQLAYFTLEPDLTTNFFTKGNKLGYIQVRIDIMVANAADLPVVEQHQPLIRDAVVELLGKQTEDTIKSLAGREDLRKSLVNRLNNILLPEVGRTVIADLLFTKYIYQ
The following text describes a protein:
Function:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
Subcellular Localization:
Nucleus.
Sequence:
MNGVNDPPLFIKDIKPGLKNLNVVFIVLEIGRVTKTKDGHEVRSCKVADKTGSITISVWDEIGGLIQPGDIIRLTRGYASMWKGCLTLYTGRGGELQKIGEFCMVYSEVPNFSEPNPDYRGQQNKGAHSEQKNNSVNSNMGTGTFGPVGNGVQSGSEARGCQFSYAGRSNGRGPINPQLPGAANNQTVMTTISNGRDPRRAFKR
The following text describes a protein:
Function:
C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. CcoP subunit is required for transferring electrons from donor cytochrome c via its heme groups to CcoO subunit. From there, electrons are shuttled to the catalytic binuclear center of CcoN subunit where oxygen reduction takes place. The complex also functions as a proton pump (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDFLNDHINVFGLIAALVILVLTIYESSSLIKEMRDSKSQGELVENGHLIDGIGEFANNVPVGWIASFMCTIVWAFWYFFFGYPLNSFSQIGQYNEEVKAHNQKFEAKWKHLGQKELVDMGQGIFLVHCSQCHGITAEGLHGSAQNLVRWGKEEGIMDTIKHGSKGMDYLAGEMPAMELDEKDAKAIASYVMAELSSVKKTKNPQLIDKGKELFESMGCTGCHGNDGKGLQENQVFAADLTAYGTENFLRNILTHGKKGNIGHMPSFKYKNFSDLQVKALLNLSNR
The following text describes a protein:
Function:
Transcription coregulator that can have both coactivator and corepressor functions.
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.
Sequence:
MPVKRPLKLDGVLKPNCFSHKLKRTRKQKWTIKCTSATLTFWPFVNHAEPVASTRNALALLSTWNILPPGKRENLNHLSINKRMESTMQDNEFMVLLSKVEKSSEEFMEIMQNLSSIQDLKGSKELENLIGIPHASCVFKREMQKTKELMTNIIKQKLFKKKNSGLPNKGQEEYMWTIMLPLLLSPFSCVRLCATP
The following text describes a protein:
Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MARTSLQVCAVLLALSGMTCILVSTVSTRWRVSSTAGTIITSTSIFEGLWMNCIGTSSGSVQCKRFSSMFSLAIHIQVCRALMIISLILGLLSCIVSLFGLKCTKFGTSDEHTKGKIALSGGLIFILAGLLCLVAVSWYAAMITAQFFDPLYLGTKYEIGSALYIGWAGSLLAVLGGSFLCCSFKKKKPAAKSGAYKYNYQDPENDFKQFKERKETSVASKAYV
The following text describes a protein:
Function:
Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MNTRGDEPRPRGTFCGKSSTLQEKVAQFYYAHGLFCSTYPGALVFVAICATLLSCYPLLNLPLPGNSPLQTWTSSVNSSSNVPPFCYIQQVVLKSTVLPWGPELHLGDAFRAPLYEAFKLLEAVRNYQDESTKKTLGHVCLHVESIRKSKSNYKNILPEYSCLVLSPANLWQQDVLKFTQDSSLLTTIFNHHNFQKGKTSITEMMFGMKVFDTGIKRYPLRNRYRIIQYAITLFFKEYDEKFVHGLRRKLQSVYSLHQNLENGTNANFATLNDTLIIQYPGEINLVEFIPITLAFLILFLYFYFSFRKIELIHSKLGMAFTSVLTVCASLTMTYGLCFFFGLTLNLEGKVVFPYLVLLVGLENVLCLTKSIVSSPLHLDVKIRIAQGLSKEGWSITKNLLLEITILTFGIFTFVAVIQEFCIFAVVGLVTDYFMQMIFFSTVLGIDIRRKENMVERHNLSFRSSLFQSQVFYDKSFGIRRSKSHPRLSSFPANIVAGQVQGAQEKKIPKRLKLVNIWTRTRFFHRAFMILMVIWISNIAYNSGFIEHFILNNSYFHEVAEQNSTSLEQNYSSIKLFPLLNTNNSFINKVSYVTHSPLNYNQNQTFDLENLKHSDYEPWLKLSPQHWSSIVRKYNLSLSGQYIAILPNIKLSHVIRPEQAVLLRNPNEKYGEKFQWQALVAALDPIDFNGMETGTRSAIPQSEQPFYPTSVFAMILIAILCFISVVVLGYTFVVLYRCICSRNYAEWRASWFSEKGEENVEEPVLLEAVPVVLEGHQQEIECTATDGVNLVSASLDGQLKVWDSGTGELIANVDRKAYFQGCFESNCGTSECDDNSSDYESGSPPSRGESYLFPRLKHRINTNFSNVKEQCNSYNAKADFLKTYRELYFVRDLPKAKSRKEMNRAKENKSISFSESNQKFCDNGHTKFDSSDAKLSPIWCMDYLENLIVLGCADGRLEFWEGSSGRLKCIFEDGTDVGISNLKIVGSRIIASRLYGTLEMFQLQTYNRGHPVDWNFTCAYRRTHVRTGSVGSVPDHTNLISQNEDEEDFRCLKVFSVKAHQQPIICLDCEGGRILTGSQDHTLKVFRLEDGSPQYTLHGHCGPITCLFIDRISPATSGSGSQDGMLCVWDLLTGACMYNIQAHDGTITSLTYSASYVISLGSDDRICVWERFQGHLLNTIYVSQTFSSQVLMLAPHLVVTARSGGLVIWDVRSGECVRTIILGRSPYIFIKQLMLLRDAVVCDYGNQLRIVRFPLITHKFD
The following text describes a protein:
Function:
May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Presynaptic cell membrane; Peripheral membrane protein.
Sequence:
MGAKQSSPAANGRTRAYSGSDLPSATASVNGRTAAVLRYNNSQGASGATSAASASSSAAVASQFISSRTRSVGPSARPQSGINIPNSGAYSSADSGNSTPEEPGGERERSTGAPRLVIGSLPAHLSPHLFGGFKCPVCSKFISSDEMDLHLVMCLTKPRVTYNEDVLSKDAGECAICLEELLQGDTIARLPCLCIYHKGCIDEWFEVNRSCPEHPAD