lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MAAKRIAQSSINWAQLAERVPPHQKGLFQQFKSKSDHYLRRVMENPEKAPEINWSFYKSRVPVAGMVDEFQKQYSALKIPYPPDTVSSQVDAQEQEIKGEIEKFKRESSARISQYEKQLAHLTSLIPFDKMTMEDFRDAYPEQALDPINRPTFWPHGPEDQPGPHDEASGHH
The following text describes a protein:
Function:
Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasmic vesicle. Endosome. Nucleus.
Sequence:
MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPRDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFTMDVIGGKFNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLDAYSHIPPQLMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQTGATSVPSKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAALPTPALTPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKKLFEEQLKKYDQLKVYLEQNLAAQDRVLRALTEANVQYAAVRRVLSDLDQKWNSTLQTLVASYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAREAARQQLLDRELKKKPPPRPTAPKPLLPRREESEAMEAGDPPEELRSLPPDMVAGPRLPDTFLGTATPLHFPPSPFPSSTGPGPHYLSGPLPPGTYSGPTQLIQPRAPGPAAMPVAPGPALYPAPAYTPELGLVPRSSPQHGVVSSPYVGVGPAPPVAGLPSAPPPQFSSPELTMVVRPATTTVDSIQAPIPSHTAPRPNPTTAPPQPRFPVPPPQSLPTPYTYPVGTKQPVPAQHHFSPGIPAGFPAPRIGPQPQPHPSRAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYSYAPQPGVLGQPPTPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSARPVGPQAAPLTIRGPSPAGQPTPSPHLVPSPAPSPGPGSVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGSTQPPGGGQPLLQPTKVDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAFRGQLGDVGALDTVWRELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLHFIQEVHAHYLHQRPLHTPIVVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKQNFLQAHNGQGLRATQPSDDPLSLLDPLWTLNKT
The following text describes a protein:
Function:
Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles.
Sequence:
MATEGDKLLGGRFVGSTDPIMEILSSSISTEQRLTEVDIQASMAYAKALEKASILTKTELEKILSGLEKISEESSKGVLVMTQSDEDIQTAIERRLKELIGDIAGKLQTGRSRNEQVVTDLKLLLKSSISVISTHLLQLIKTLVERAAIEIDIIMPGYTHLQKALPIRWSQFLLSHAVALTRDSERLGEVKKRITVLPLGSGALAGNPLEIDRELLRSELDMTSITLNSIDAISERDFVVELISVATLLMIHLSKLAEDLIIFSTTEFGFVTLSDAYSTGSSLLPQKKNPDSLELIRSKAGRVFGRLAAILMVLKGIPSTFSKDLQEDKEAVLDVVDTLTAVLQVATGVISTLQVNKENMEKALTPELLSTDLALYLVRKGMPIRQAQTASGKAVHLAETKGITINNLTLEDLKSISPLFASDVSQVFSVVNSVEQYTAVGGTAKSSVTAQIEQLRELLKKQKEQA
The following text describes a protein:
Function:
Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).
Subcellular Localization:
Nucleus.
Sequence:
MSSPGISDESIKGPKDVRLIHLILSSLGVPSYSQTVPLQLLTFAHRYTQQLIQDSQVYAEHSRGQNAPISVEDVRLAVASQINHSFTGPPPKEFLLELAMERNRKPLPQIQPSYGFRLPPEKYCLTQPNWIVSNETQQNQPKEENSSDSRMEEDKLDFSVKSE
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex.
Subcellular Localization:
Nucleus.
Sequence:
MHRAVDPPGARSAREAFALGGLSCAGAWSSCPPHPPPRNSWLPGGRCSASIGQPPLSAPLPPSHGNSSGHPNKPYYASGTPTPRPLHGKLESLHGCVQALLREPAQPVLWEQLGQLYESEHDSEEAICCYHRALRYGGSFAELGPRIGRLQQAQLWNLHAGSCQHRAKVLPPLEQVWNLLHLEHKRNYGAKRGGPPVKRSAEPPVVQPMPPAALSGPSGEEGLSPGGKRRRGCSSEQAGLPPGLPLPPPPPPPPPPPPPPPPPPLPGLAISPPFQLTKPGLWNTLHGDAWGPERKGSAPPERQEQRHSLPHPHPYPAPAYTAHPPSHRLGPATPLGPGPRPPGAESHGCLPATRPPGSDLRESRVQRSRMDSSVSPAASTACVPYAPSRPPGLPGTSSSSSSSNNTGLRGVEPSPGIPGADHYQNPALEIAPHQARLGPSAHSSRKPFLTAPAAAPHLSLPSGTPSSPPPPCPRLLRPPPPPAWMKGSACRSAREDGEILGELFFGAEGPPRPPPPPLPHRDGFLGPPNPRFSVGTQDSHTPPTPPTTTSSSSSSSSSNSHSSSPTGPVPFPPPPYLARSIDPLPRPSSPTLSSQDPPLPPLTLALPPAPPSSCHQNTSGSFRRSESPRPRVSFPKTPEVGQGPPPGSLSKAPQPVPPGVGELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQQEAGAVPPPPLKEPFASLRSSLPSDTAPAATTAAATPTTTTTTTTQEEEKKPPPALPPPPPLAKFPPPPQPPPPPPASPASLLKSLASVLEGQKYCYRGTGAAVSTRPGSVPATQYSPSPASGATAPPPTSVAPSAQGSPKPSVSSSSQFSTSGGPWVRERRAGEEPAPGPVTPAQLPPPLPLPPARSESEVLEEISRACETLVERVGRSAINPADPVDIADPVDSGTEPQPPPAQAKEESGGVAVAAAGPGSGKRRQKEHRRHRRTCRDSVGRRPREGRAKAKAKAPKEKSRRVLGNLDLQSEEIQGREKARPDVGGASKVKTPTTPAPPPAPAPSAQPTPPSAPVPGKKTREEAPGPPGVSRADMLKLRSLSEGPPKELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAADVMRASKNAKVKGKFRESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQEEKESEDEESEEPDSTTGTSPSSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTLAPASTSR
The following text describes a protein:
Function:
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.
Subcellular Localization:
Postsynaptic cell membrane. Presynaptic cell membrane.
Sequence:
MALSENCKTQPAKEQGTVQNPPTDVIELNVGGQVYYTRHATLTSIPNSLLGKLFSNKKGSLNDLSRDLRGRYFIDRDGFLFRYVLDYLRDKQVVLPDHFPERGRLKREAEHFQLPELVKLLSADESKLFPDDLYCSDLEDASQCSERFYSSFSFDRRYGYITVTFIGACAARSREGHTETKNKKLPRIFISSRIGLAKEVFGDALNENKDADRPSDRYTCRFYLKFKHLERAFDMLSECGFHIVACNTSLTSSSMGHYTDDRAWSNHSQYIFYRGPSRWSSSHCDCCCKSHKSEREGESGTSLNDLSTSCSETQSEASSPQGTVIRGPVSRQSNIQTLDRSLPKGPVHMLQQADMRRKTEMLRVRTFGVREREAAKRKANKEKMTPEQELEKCIQDFRRIRIPDHFPERKYMWQSELLRKYRL
The following text describes a protein:
Function:
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Subcellular Localization:
Cell membrane. Membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MFRLYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYRLWASVSPHINLTWHKNDSARMVPGEEETRMWAQDGALWLLPALQEDSGTYICTTRNASYCDKVSIELRVFENTDASLPFISYPQILTLSTSGVLVCPDLREFTRDKTDVKIQWYKDSLPLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRTVELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHVESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLNMDFKCVVRNTLGFQTLRTTVKEASSTFSWGIVLAPLALAFLVLGGIWMHRRCKHRTGKADGLTVLRPRHQDFQSYPK
The following text describes a protein:
Function:
May play roles in cilia formation and/or maintenance.
Sequence:
MTPQVPVPRPSYSQARESLVKAVPPKIICLLACGGRDCRYEGPACWSTNQQAIKGIFSSWVTDDILAMARPSTYLMKRYSIIEQFKQLNIKSIINMQLPGEHAHCGPPLEPDSGFTYSPQSFMDNQIFFYNFGMSDFGVSSLEGMLDAVKVLAFSVQEGKVAVHCHAGLGRTGVLIACYLVYTCRISASEAVHYVRIKRPRSIQTRSQINLVFDFARLLGSQLAQFPSLNTRHCATFSLRQYLLRQALLLHGDEARTLKHTPKILHVLCSMMISLTQGSAGPPEVQRELEKRANVLALKKAVKETLLKRNLPVIKERRGSCRTFSCESWDEPFGFLERKRDVLLNKRSYSESDLSKITIIEDFMFSHCYTQSAGHHKTSNGEIGREKDPRIPTESQKYPQIPTTDQCNGTTQTQSPIPPSAPPAHTETVNKKTKCTTKKPQAFQKFGSNIELRRDDFPSDQSSLSRAVAKALAQQRPPLDSVLKRAAVLQDELNLSECGWATLGMETDPDVLSTLLWIWLDKLKDPILSKDDIERLTLTWPAQNPLITLHKIQRQTVFCLLDCVGHVVVRCPQFEHAILQRLIRALTRRPPEEIERNNILLRVLRASTRELYLQNHHSNTTTAAKC
The following text describes a protein:
Function:
Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Domain:
Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity; Cys residues in the pre-SET domain normally bind 3 zinc ions that are arranged in a triangular cluster, but here these Cys residues are only partially conserved, suggesting that the pre-Set domain may not bind a zinc cluster.
Sequence:
MVSTPPTLLMLFDDGDAGPSTGLVHREKSDAVNEEAHATSVPPHAPPQTLWLLDNFNIEDSYDRDAGPSTGPVHRERSDAVNEEAHATSIPPHAPPQTLWLLDNFNIEDSYDRDAGPSTSPIDREASHEVNEDAHATSAPPHVMVSPLQNRRPFDQFNNQPYDASAGPSTGPGKRGRGRPKGSKNGSRKPKKPKAYDNNSTDASAGPSSGLGKRRCGRPKGLKNRSRKPKKPKADDPNSKMVISCPDFDSRITEAERESGNQEIVDSILMRFDAVRRRLCQLNYRKDKILTASTNCMNLGVRTNMTRRIGPIPGVQVGDIFYYWCEMCLVGLHRNTAGGIDSLLAKESGVDGPAATSVVTSGKYDNETEDLETLIYSGHGGKPCDQVLQRGNRALEASVRRRNEVRVIRGELYNNEKVYIYDGLYLVSDCWQVTGKSGFKEYRFKLLRKPGQPPGYAIWKLVENLRNHELIDPRQGFILGDLSFGEEGLRVPLVNEVDEEDKTIPDDFDYIRSQCYSGMTNDVNVDSQSLVQSYIHQNCTCILKNCGQLPYHDNILVCRKPLIYECGGSCPTRMVETGLKLHLEVFKTSNCGWGLRSWDPIRAGTFICEFTGVSKTKEEVEEDDDYLFDTSRIYHSFRWNYEPELLCEDACEQVSEDANLPTQVLISAKEKGNVGRFMNHNCWPNVFWQPIEYDDNNGHIYVRIGLFAMKHIPPMTELTYDYGISCVEKTGEDEVIYKGKKICLCGSVKCRGSFG
The following text describes a protein:
Function:
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Sequence:
MAAQRPLTIALVAGETSGDILGAGLIRALKARVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTRRFTELKPDVFVGIDAPDFNITLEGNLKKKGIKTIHYVSPSVWAWRQKRVFKIGRSTHMVLAFLPFEKAFYDKFNVPCRFIGHTMADAMPLDPDKNAARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQRYPDLEVVVPLVNAKRREQFEKIKAEVAPDLAVHLLDGMAREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTEYVSLPNLLAGRELVKELLQEECEPQKLAEALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAADAVLELAQ
The following text describes a protein:
Function:
Forms a fork protection complex (FPC) with TOF1 which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors and protects stalled replication forks against the fork-releasing activity of RRM3 helicase.
Miscellaneous:
MISCELLANEOUS: Present with 358 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDQDFDSLLLGFNDSDSVQKDPTVPNGLDGSVVDPTIADPTAITARKRRPQVKLTAEKLLSDKGLPYVLKNAHKRIRISSKKNSYDNLSNIIQFYQLWAHELFPKAKFKDFMKICQTVGKTDPVLREYRVSLFRDEMGMSFDVGTRETGQDLERQSPMVEEHVTSAEERPIVADSFAQDKRNVNNVDYDNDEDDDIYHLSYRNRRGRVLDERGNNETVLNNVVPPKEDLDALLKTFRVQGPVGLEENEKKLLLGWLDAHRKMEKGSMTEEDVQLIQSLEEWEMNDIEGQHTHYDLLPGGDEFGVDQDELDAMKEMGF
The following text describes a protein:
Function:
Orphan receptor. Regulates egg-laying probably by activating guanine nucleotide-binding protein goa-1, in the hermaphrodite-specific neurons (HSNs).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MYPFNRTTSIHAESASQHIDELDDDDFGRSNGKFYSNRHSQMDSDVVAHQVPPGSPVEKTILASILEMSTINDMWVKTFTAPGANKKDKKRRESLFECSWRGVHCVSNSLRSILFLFRLLAIFPATTDRKSRRKRNHRSIIKLILYVNYIVLAVLLNSFLIKMNFKVLMLYKHKFGLMHTGTVASMITATKPVINVFVIVLSAIKFKSHQRLLKTIDMVDVCFRSAFGVSPPLRIYKFVFFFTLLIIFFSALILKVVEFVGTGEIFGEHILTDCSFILVPVLSLWNIIPLLYYHLYNILVRFYCRTLIKSMNREHKKRHFSLKFYYEQFTRITNVQEAVGDVFNPLLLFSLAWSLLVLCLTLYFLSEPTSTLLVPITPEQVTNPKIREKLNITVHVKICWAAYQVVMAILHIIIICSTGMMTNETTRQIVNAVLRIVPDANADLDRFQISCFVHKMTTQFMWGMTVWRAFPLERTTFFTLISVIVTYSLLLFRFKDDMVQNPPYMAAMAVFNTSAVPTPAPG
The following text describes a protein:
Function:
May be involved in protecting plant tissues from pathogen infection.
Subcellular Localization:
Secreted, cell wall.
Sequence:
QNINWDLRTASVFCATWDADKPLSWRSKYGWTAFCGPVGPTGQDSCGKCLLVTNTGTGAKVTVRIVDQCSNGGLDLDVNVFNQIDTNGQGNAQGHLIVNYDFVDCGD
The following text describes a protein:
Function:
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.
Subcellular Localization:
Cell outer membrane; Lipid-anchor. Note=A substantial portion is found inside the LptD beta-barrel.
Sequence:
MRYLATLLLSLAVLITAGCGWHLRDTTQVPSTMKVMILDSGDPNGPLSRAVRNQLRLNGVELLDKETTRKDVPSLRLGKVSIAKDTASVFRNGQTAEYQMIMTVNATVLIPGRDIYPISAKVFRSFFDNPQMALAKDNEQDMIVKEMYDRAAEQLIRKLPSIRAADIRSDEEQTSTTTDTPATPARVSTTLGN
The following text describes a protein:
Function:
May play a role in uric acid excretion.
Miscellaneous:
MISCELLANEOUS: Isoform 4 (talanin) of ZNF365 does not exist in rodents. In primates, a canonical intron-exon structure exist, with several stop codons preventing talanin production in old world and new world monkeys. It seems therefore that isoform 4 transcript emerged during primate evolution from a noncoding genomic sequence.
Sequence:
MSALGQITITVSRCWNTERNQTDKNPCLHGAYLQLRETVKNKSTHLKKPLMKQAPPWKDHLTFQPLHPAERKTQVWRWQSGNSSDLETTSSASPWPTGSNRDVVLNTLAESCCGLSELITAPPYAGVSIQGFSQIWVLFPFCGGTFHHNEKDVLGLQDFERESVSTSQSRNISLLTLGQLQNCVIGKLTIIDLLTEHLLGVRHGVICFPWGLPSSS
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MKSLLFNRKYQSRYTKVAIVNHICPSQVSIVNHIYPSVVVSIVNHICPSVYGHRCYSTKDTILEKFWESFYSQLLDDSNTNSRSESNVSQYHKYVIDLLNNSKKDKDSFTEEELISIQTSIEDATFKYDDIKNIYQLTPDLIKIIISKDELTAKEYLKKCKLTKNDLLTLEYFDQYTLEAIIIYVFGVLFNCIQELPAVRVSTLIEHLDTYVRSQAKLLKGYTSEERPSTKHEINSDDTSSNVKAEENEMANDKMQNNYAFGAFLVEFLVNRKWISLSNELSFHEQYSVTMKNGKYYIPRQLYAICNFDISLLPIKLNLPMICKPLDWKPIRDDIIPSSLSDMRGGYLSIPSGDFYQQKRYRVMTTRDLSHFHIKFDEGKYDDLCLTMNKLQAQSFEIHKDVLSFIMNNNELLVKYGLLMPRFLASLNINRAVELLRNSYLSNNDLTQVCNYQDLLKVFLERIQRARYETFVINIASAYEGYKIYLPAFVDFRGRIYRAGVLHFHERDLARSLVLFTCNNPSGELINHNIDDKEIMFIASAAAAFHYKKFESYKDSYQWYLDHVSMKASSAESIIELALSAADPYQFISKVLCIESNNKSNLIQIPITQDASASAYQIMSYFLLDNDLALKTNLIPYIDYHYSPEYDFSDNKKIKDIYTILLEELKVYFRKELTNNLADIVCPRLTRKLVKVLFMPMIYGKTVISIANDFNQHFDSLLDKGECMQLAKKIYIFYKTYYPGIVNLMDLIRNISWLVSAMDRPVLYSVSLFTTVQDYMKSKTVNIWVYDRIHRKRRQVTLRIPSGDRDRRKTHMSTFANFIHQKDAFIAMHMIKYMVSENAPVYTVHDNFITTAPYASYISRYYVLVLYNMGSPLLWINQFIDLNLAIDRNSYTLESPIPNHILLNSLESIIPKNLNKSKKLIWAKKIYSVCIAYEKYIMDLYDNNPKTVDLENKRVAFIGNMLNWDNCKYKYCLHL
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSEQFLYFLQQMFNGVTLGSTYALIAIGYTMVYGIIGMINFAHGEVYMIGSYVSFMIIAALMMMGIDTSWLLVAAGFIGAIIIASAYGWSIERVAYRPVRNSKRLIALISAIGMSIFLQNYVSLTEGSRDVALPSLFNGQWIVGSSENFSASITTMQAVIWIVTFLAMLALTIFIRYSRMGRACRACAEDLKMASLLGINTDRVIALTFVIGAAMAAVAGVLLGQFYGVINPYIGFMAGMKAFTAAVLGGIGSIPGAMIGGLILGVAEALSSAYLSTEYKDVVSFALLILVLLVMPTGILGRPEVEKV
The following text describes a protein:
Function:
May function in G-protein coupled signal transduction.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKFGKVIEGQSVAEWASAYFDYKKGKKIIAGIAKNPSEGLYGTSGILGETPEEAIVKRGQIHRFHPLFQEFLDQQANKVEEFFENLVSDARERMDLISDQVDIYEKLRAFKKGTLESGSVVLIQKQHSKLRQRLDSILNFSRLQPAYHIPARKSVPTDAYTPMVSYRKLKSKLKTTLLDFYDYLKLVSQYQHLNQQAFRKIVKKYDKTLHTDLQGFWVDYMSRYTFTDFSITTNWQLHVEDIYARLFTNHNKKLALEHLKSFRQKEHFSANSMRFGLLFGAGLPLAIEAACYYNATEQSSYLLQIWGGFFLVIFAFVLFDLDCYVWEKTRVNYMLIFEFNQRKSLNWRQHLEIVGAVFFIFSLFFFLCMRNFFPGFTIYFPALFLGVVGTFLIAPVIVPYWRMRRYLIIQLIRVFLSGLSTVHFQDFFFADQMVSLTYACGNISLFFCLYKRLWRQPQLCNSSHSPLLGFFTTLPGILRVFQCFRRYSDSLKSFPHLVNALKYIFNILAQMFLSLWRIHPGLKYRVLYTIFAGVNSLFSYTWDILMDWNLLVRKDGRWQFREHRILKQLWPYIIAMILNFIVRSSFIFYCIFPNHIQHSSGISFFVTLAEIMRRCMWNILRVEHEEIYNRENLRAARELKPLDFVKPHSDVFVSHQISSDKNYTDDEDSMDDQTDVDEAQFS
The following text describes a protein:
Function:
Involved in transport of proteins into the mitochondrion. Essential for embryonic development.
Subcellular Localization:
Mitochondrion outer membrane.
Sequence:
RSVWARRHGNGAYCEGGSLTVSSPKGPVKREGRKERGTNGSFPSAAWLRPALCCALSPWQPVWVDSNACFGPGLGLEQAHEPANRGRFRLSPASPAFPSQFRFRAKQDGGSCGVLLLGGRLGPAVGGPSVPGRPGTLPALKTPDEGVLSDPQQIITYLRKQRFNADYDLSARQGADTLAFVSLLQEKLLPVLIHTFWVDAKNYVELTRKWYAEAIPFPLNFFLPGRMQKQQLERLQTVCGENCLENEEELEKELYREARECLTLLSQRLGQQKFFFGDSPASLDAVVFSHLAPLLKAKLPNAKIQQHLKSLPNLCNYCTSILSLYFPWDEGDPPPPVPKSASSDGSESEEEPHKRRNQVLSVLVGLLAMVGYALLTGIVSVQKQGPGTGGRRAIALDEEEEEEEEE
The following text describes a protein:
Function:
Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MWLSLSITFLVMGSSVAESDHMEIRLEGGPNLCSGRVEVFISGEWTSVCDDSWGIEEAMVVCRQLGCGSAVSATHEAQFGNGNVSIGLDDVRCGGTESTLSECPASPWGEHDCSREETAGVVCSGQPWGSDPTHQTEIRLAGGLNNCYGRVELLHHGEWGTICGDGWGTEEATVVCQEMGCGTVSMDQSRTWNESGASPIWLDDVHCRGTESSLHQCSASPLGRHDCDSGETASVVCSEVRLVDGLTPCTGRVEVFHNKGWGTVCDNGWDLEDARVVCQEVGCGKALVAATGARFGQGSGPIWMNQINCTGKENVLKKCPQEKSFNLTCDHRKDAGVECAVMRLADGHNPCAGKVELLHEGQWRMVDGLYRHIEQARVMCRYLGCGIALSALIYPIYGKKTALFWLDGFYCTGTETSPCECERVPGMKYDFNWHRVFYMAGVVCTELRLVNGSSNCSGRVEVFHNETWGTICDAGWDLQDAQVVCRELGCGEALSASGGAQFGRGAGPIWLEGMSCIGKEESLRQCPKGQWGEHSCDHSRDASVECTDPRKIRLVNGFSRCSGRIEVFQNQEWGTLCDFEWDLNDARVLCKELGCGDVISVPWGAHFERTRSPVLPLIFYCNGTEDALNDCENYPMLGGPYCHQGEGAGVVCSELRLVNGPNRCSGYLEVLYNQQWGTVCDIGWDTHDAQVVCRELNCGDNAKAFGGVCYGQGSGPIWLENVNCTGEEIALAECPKSPWGKHSCNHSQDVNVECSGQVRLANGSSLCSGRLEVFLEQQWKSICDDDWDLEGSEIVCRTLNCGHALSAPRGSHFGRKYNTIKIRLDFCNMTTDSLTNCDLRDWGPCDSGGSAGVICSEAHLVNGTNRCSGRVELFHNKQWGTVCDAGWDTYDAQVVCRELGCGNALKAFRGAHHGQGFGPIWLEGVNCTGKETSLRECPQNPWGEHHCNHSQDASVECTGWIRLINGSSHCSGTVEVLHNQHWKAICDKNWGLYEEHVVCREMGCKQIPWNPRSARLLSKYRVNRLSIPFCKWTANDLAECNLTDFKEESCSHGRTVAVTCSGTRLVNGSNRCSGRVETFLHREWRSWCLDEWDLRDAQVVCRELDCGEAESVPGRSFFGRGEGSITFDEPKCLGTEDAFHKYLRLMNGTSPCSGRVEVFHNDTWGTICDAGWDLQDAQVVCSQLGCGKASKALGGAHYGQGSGPIWLENINCTGEEASLKECQKGIWGEHSCSHSQDASVECSGTCLPQVLFPGT
The following text describes a protein:
Function:
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Sequence:
MSNKSVLLIAGEPSGDLLGAHLAQSLKSLEPNLKLAGMGGKRMREAGVEVFINADKLAVVGLLEILRQFRDIRHAMQTLKRYFKKTPPDLVVFIDYPGFNLHMAKQAKKAGIKVLYYVSPQIWAWRYGRIKKIKKYVDHMAVLFDFEEKLYQKENVPVSFVGHPLANAPTPSLSRNEICKQFNLDPDKPIVALFPGSREQEINKLLPMMVQAGKLIQTQIPTVQFILPLALNLALDKIRPFLSPEIKVIQNDISYVLAIAHAAVAASGTVTLEIALQQVPLVIIYKVAPLTFWLGKKLIRLSFIGLCNLVSPEPVAVELLQQDATPQAIADEVFQLLNNHNYRQSIIGKLGHLRPQLDRGNAAQNVAKVVHNLIFS
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTTTTIQFNALLLDIEGTITSISFVKDELFPYAFENVGNYLEEHYDNPATQIIVEDLRHIADQQAENDVAVVRIREPRKECIEDVTKNVRHWIKRDKKLTPMKALQGLIWEEAYQRGDVKGHVYPDVLPVLKIVENRKIPIYIYSSGSVHAQKLLFANSIEGDMTKILYGYFDTNIGLKGESNSYTKISERIKIPPSEILFLTDVEAEAAAAKKAGLQTKLVVRPGNAGLTQEAINAYGTIESLEEIL
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC2. The C-terminal helix of the antitoxin may obstruct the toxin's RNA-binding groove, blocking access to the active sites. Additionally, the C-terminal arginine of the antitoxin may remove Mg(2+) ions from the toxin active sites.
Sequence:
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSVPTLSNKPETVDLLVLAPGEKKVTCTISDKGDCNIFVIKLEDHTIGNLIKIQLCQDPKVLFAAYRQPHPLQNAIEITIKPKGYAGVKLLSDNVNNILSQVATLKENFAKKIQKYKESNSYYEDY
The following text describes a protein:
Function:
Member of the two-component regulatory system YvrG/YvrH that positively regulates 7 transcriptional units (wprA, wapA-yxxG, dltABCDE, sunA, sunT-bdbA-yolJ-bdbB, sigO-rsoA, and sigX-rsiX), and negatively regulates the lytABC operon. Probably activates YvrH by phosphorylation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNSGLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDVPGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQKIDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPWNYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWMTVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFESMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPEEVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNPFSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHISLKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSRTNIGTVITILFKKQ