lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes activation of the trans-4-hydroxy-L-proline dehydratase under anaerobic conditions by generation of an organic free radical on a glycine residue, via a homolytic cleavage of S-adenosyl-L-methionine (SAM). Is involved in the anaerobic degradation of 4-hydroxyproline.
Sequence:
MNPLVINLQKCSIHDGPGIRSTVFFKGCPLECVWCHNPESQTYTKQVLYNEERCSKCEACINICPHKAIYKGETKICLDQDKCEFCETCLDYCVNNAREIVGQEYSVRDLVKEIEKDRIFYEESGGGVTLSGGEVMAQDMDFICGVINMCKSKGIHVAIDTCGYAKSENYERVAKCADLFLYDIKLIDEDKHIKFTGKSNDLILKNVKILSELGANINIRIPLIVGVNVDDENLEVKKMIEFLKPLNIQAVSLLPYHNIGKHKYDKIYKKYEGEELQRPSEEKLEEIKRLFEASNFNTKIGG
The following text describes a protein:
Function:
Acts as a component of the ssn6-tup corepressor complexes, which are involved in the repression of many genes in a wide variety of physiological processes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Nuclear dots.
Sequence:
MPQSQVATASPSQNAQPNHGMGSKVLSSDPNASLPPQTAYYASPLHANSVSLPPSHLPRSTLHPLLSQQQQPAQQSPSLGPAQQNIQQPPSVSIASQPHYAEAIVPIQQVLQPQQYRQLPPNMVAATNAPQQHPQLQRMMPILSSNQPIQQLPLPNQASPYIPVPLQQQQQSQPQQQPQQQQHQQPQQPQPPQQPLQQQQQQRQLHSGIQQPVSTIVSQNGTYYSIPAVNHPMAGQPIAIAPVPAPNQAALPPIPPQALPANGTPNTLASPVTLPAANSAVQNAQPVPMTSSPAMAVVPQNKTAATSTLAAQQGANVLPPNAPESVRHLISLNEETWIQIGRLAELFDDQDKALSAYESALRQNPYSIPAMLQIATILRNREQFPLAIEYYQTILDCDPKQGEIWSALGHCYLMQDDLSRAYSAYRQALYHLKDPKDPKLWYGIGILYDRYGSHEHAEEAFMQCLRMDPNFEKVNEIYFRLGIIYKQQHKFAQSLELFRHILDNPPKPLTVLDIYFQIGHVYEQRKEYKLAKEAYERVLAETPNHAKVLQQLGWLCHQQSSSFTNQDLAIQYLTKSLEADDTDAQSWYLIGRCYVAQQKYNKAYEAYQQAVYRDGRNPTFWCSIGVLYYQINQYQDALDAYSRAIRLNPYISEVWYDLGTLYESCHNQISDALDAYQRAAELDPTNPHIKARLQLLRGPNNEQHKIVNAPPSNVPNVQTAKYINQPGVPYSNVPVAQLSGNWQPPHLPQAQLPSATGQSGVVQQPYQTQPSVTNNNVATQPVIASTVPVQTAAPSSQTAVPQTIHQSNAFTPRGKHASGSRNSISSTKSPQHKLSDQPRSRNNSISNVSHRERSNSVSSKSRETRTSASNESDPKKSTQRDSSKKLENSTVVSGSPSSSSKSDAAKSIKPQKPEPALKPVEGTADPKSTKRNHQETEKTADTDVSSTEPVKRQKTADVNDDVGEEEVKQSVSEQVDSAQLTSEPKSESLPKSPEEKSDDTSNDVTTENTNDINGDSNMDNVATVDKSTDAVDTSTATVAATTTTAEEELPQKESQERSSPSPENQDSTPLAPKSVSPKQAARTLDIDENYDDDEGEKETVSV
The following text describes a protein:
Function:
Needed for the assembly of the mitochondrial F1-F0 complex at high temperature.
Miscellaneous:
MISCELLANEOUS: Present with 589 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MDRPRTLRTYRGLIRAILKYERPSKIVNWGNLRKAMITKLEYAKKQNQRDSHENINRQLEKWKKLDPVSDRSLNLFIADSKSLRSILQNDIKWEKKVAQGQNVDEIFEHALDIIKFLDNQREYEELVDRYNPGNKLTQDEKVKRTANVVGLDVPT
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSTQDIYDAVYPLLLTTASFGLSAIFVETKNNTRKLAVFNLLKILNIIYLSLFSALLYVAFTSLKNTHLHVNYNSGVTKIGIIFQILANIMATYVIYFINISKSHNILTCIENIKKADLMFRDLGEKIIYRKHFLYEVCMILFGVLAILGRSIVTHIYMGRNIFLTENETHFALFFPLFVSYLVQINFVLLITLVHERFALINRLLDNFNEEKVKHNYLSLKPPYEYQTKYNQAKIELLMELHDFLTDVGNKLNDSFSIQILSCLTSQFLTEVFTIFYLYYESLILKNKIAALVWLMWSIWTTLEIFYVTVNCHLTTKEAKNTGIAIHKVLMNESDPDAKRKLMVFSQQVNHRSLQFTACGLFYIDATLIFTIVGAAATYLLIMLQFQEGIEAQCSNNTLLN
The following text describes a protein:
Function:
Secreted effector that acts as a pathogen-associated molecular pattern (PAMP) recognized by the plant immune system. Induces necrotic cell death and ethylene biosynthesis in parsley. Stimulates early induced host cellular responses implicated in elicitor signal transmission such as increased levels of cytoplasmic calcium, production of reactive oxygen species (ROS), and MAP kinase activation. Infiltration of NPP1 into leaves of Arabidopsis thaliana results in transcript accumulation of pathogenesis-related (PR) genes, production of ROS and ethylene, callose apposition, and hypersensitive response (HR)-like cell death. NPP1-mediated induction of the PR1 gene is salicylic acid-dependent, and requires both functional NDR1 and PAD4.
Subcellular Localization:
Secreted.
Domain:
The structure of NLP effectors is remarkably conserved with a high level of conservation of a central region containing the conserved undecapeptide motif AIMYAWYFPKD and heptapeptide motif GHRHDWE.
Sequence:
MNVLTFLIAAAVSLAVVQADVISHDAVVPFAQPTATTTEQKAGVKFKPQIHISNGCHPYPAVDANGNTSGGLKPTGSSSAGCKGSGYGSQVYGRVATYNGVYAIMYSWYFPKDSPVTGLGHRHDWEHVVVWVDDIKLDSPSIIAVSPSAHSGYNIYYPPESNTIDGYSAKVDYSSSWVVINHALDSTTDAGETQDLIMWDQLTDAARTALENTDFGDANVPMKDGNFLTKVGNAYYA
The following text describes a protein:
Function:
Does not have an essential role in development.
Sequence:
MDLWHIFLERILVACRVSASVFANFGCGLYSSWKLICGDHDSASGLRAGLATPTQRGKATGDNGTTGTPARTIGKPQARIATAMSTATCARFCTPLSSGTAGSTSKLTTGNGSGNTMTSAYKIPSNNSTTANDSSNTETTFTFKLGRSNGRSSSNVASSESSDPLESDYSEEDPEQEQQRPDPATNSRSSSTATTTTTSSADHDNDVDEEDEEDDENEGEGNGRDADDATHDSSESIEEDDGNETDDEEDDDESEESSSVQTAKGVRKYHLDDYQIIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKNERNILREIRHPFVISLEWSTKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLINRDGHLKITDFGFAKKLRDRTWTLCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYEMLVGYPPFYDEQPFGIYEKILSGKIEWERHMDPIAKDLIKKLLVNDRTKRLGNMKNGADDVKRHRWFKHLNWNDVYSKKLKPPILPDVHHDGDTKNFDDYPEKDWKPAKAVDQRDLQYFNDF
The following text describes a protein:
Function:
Sodium permeable non-voltage-sensitive ion channel (By similarity). Involved in the activity-dependent removal of selected presynaptic proteins, such as synaptobrevin snb-1, and Ras-related rab-3, in the remodeling of GABAergic motor neurons.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSPLLTWNLICVSSRWYTILCLKNKVKFWLGTRLVHEPESMESRSSPYIRPSPYAGGVHPHFEEEDDRSKLHASALYSERRTSSRKSLRSQKIDYHTTTIKSLWFDFCARTSSHGIPYVATSSFFGRYVWAALFMCMLMAFLLQTYWTMSEYLQYRTIIEMQLQFEAAAFPAATVCNLNAFKYSELTQYEEIKEGFDYWERVINARMMSDSMKPGGDILEAISVRKKRSKSRDQLLFPIDDEDLEGAVYQPVFVRCTCMNMEQCVPNRNPLEVNASICMCFEDVTRGLIWPCYPTSVWTVKKCSGCSISNTCPDPDGPNASKQIAKHNSPLPCLCQSISHHCMVHPKDEIRWWNPNNYTVYSVTEPPTTEITETEEAFGLSDLKDAGAITTQTKENLIFLVAALPRETRRNLSYTLNEFVLRCSFNSKDCSMERDFKLHVDPEYGNCYTFNFNDSVELKNSRAGPMYGLRLLLNVHQSDYMPTTEAAGVRLVVHEQDQEPFPDTFGYSAPTGFISSFGLKTKELHRLSAPWGNCSDTFRPVPYIYNEHYSPEGCHRNCFQLKVLEICGCGDPRFPLPSEEHRHCNAKSKIDRQCLSNLTSDSGGYHHLHEQCECRQPCHEKVFETAYSASAWPSQNFKIGTDCPAVSDIFNDTEACTEYYRQNTAYIEIYYEQLNFESLKETAGYTLVNLFSDFGGNIGLWIGFSVITFAEFAELFCEICKLMYFKGIVYVQKKMQGKEYTSSSLMHIDFLQRSPKKSQPGEDEVSTNESTKELMSK
The following text describes a protein:
Function:
Secreted effector that enables the plant pathogenic fungus to manipulate host defenses for successful infection. Binds chitin fragments and blocks the activation of chitin-induced plant defense responses. Protects fungal hyphae against hydrolytic plant enzymes.
Miscellaneous:
MISCELLANEOUS: In plants, chitin acts as a microbe-associated molecular pattern (MAMP) that is recognized by lysin motif (LysM)-containing plant cell surface-localized pattern recognition receptors (PRRs) that activate a plethora of downstream immune responses.
Domain:
The LysM (lysin motif) domains are small globular domains involved in binding chitin in eukaryotes. Mg3LysM contains 3 LysM domains.
Sequence:
MQNIFLAATLLGAAFAAPQNPPTSCSAAPQPTGTGSPGTVCGSTTFTNYTVKAGDTLGAIAKQYNSGVCDIAKVNGIDNPDYIKPDQVLSIPANCVTPDNTSCVKPVPVITNTCVLGVGSTYTVKSGDSFSAIATSFNITLASLEARNPQIPNYDLIFPGQVINTPLCPNSVCDSIGTYVIESGDIFYNLAQSNNVTVGQLESLNVNVNVTDIHPGDIIILPHNCHNITASA
The following text describes a protein:
Function:
G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated. Succinate-SUCNR1 signaling serves as a link between metabolic stress, inflammation and energy homeostasisn (By similarity). In macrophages, plays a range of immune-regulatory roles. During inflammation, succinate-SUCNR1 signaling may act as an anti-inflammatory mediator or boost inflammation depending on the inflammatory status of cells (By similarity). Hyperpolarizes M2 macrophages versus M1 phenotype through Gq signaling by regulating the transcription of genes involved in immune function (By similarity). In activated M1 macrophages, plays a pro-inflammatory role in response to LPS (By similarity). Expressed in dendritic cells, where it is involved in the sensing of immunological danger and enhances immunity. Mediates succinate triggered intracelleular calcium mobilization, induces migratory responses and acts in synergy with Toll-like receptor ligands for the production of proinflammatory cytokines as well as an enhancement of antigen-specific activation of helper T cells (By similarity). In the small intestine, mediates the activation of tuft cells by dietary succinate and triggers type 2 immunity. In adipocytes, plays an important role in the control of energy metabolism. In response to succinate, controls leptin expression in an AMPK-JNK-CEBPA-dependent as well as circadian clock-regulated manner. In muscle tissue, is expressed in non-muscle cells and coordinates muscle remodeling in response to the succinate produced during exercise training in a paracrine manner (By similarity). In retina, acts as a mediator of vessel growth during retinal development. In response to succinate, regulates the production of angiogenic factors, including VEGF, by retinal ganglion neurons.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAQNLSCENWLALENILKKYYLSAFYGIEFIVGMLGNFTVVFGYLFCMKNWNSSNVYLFNLSISDLAFLCTLPMLIRSYATGNWTYGDVLCISNRYVLHANLYTSILFLTFISIDRYLLMKFPFREHILQKKEFAILISLAVWVLVTLEVLPMLTFITSTPIEKGDSCVDYASSGNPKYSLIYSLCLTLLGFLIPLSVMCFFYYKMVVFLKKRSQQQATVLSLNKPLRLVVLAVVIFSVLFTPYHIMRNVRIASRLDSWPQGCSQKAIKCLYILTRPLAFLNSAVNPIFYFLVGDHFRDMLFSKLRQYFKSLTSFRL
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAGGGSDPNARTKITWHIGGWGNPYEGGGRPGKGVVTYALSPNRQRPMANFIAKGFWNVARRSKNQILYIIPPFLVAYGTMQWAIEKNEFYNSKTGRALFGDEE
The following text describes a protein:
Function:
A farnesyl diphosphate (FPP) phosphatase. Involved in biofilm formation, its disruption blocks biofilm synthesis which is restored by exogenous farnesol. Releases diphosphate from FPP, was initally suggested to be a squalene synthase. Diphosphate release is higher from FPP than geranyl pyrophosphate (GPP) or geranylgeranyl pyrophosphate (GGPP). Biofilm synthesis is partially restored by exogenous squalene, beta-carotene or retinol. Required for integrity of cell membrane lipid rafts. Involved in spatial organization of membranes, required for the flotillin-like proteins FloT and FloA to function correctly.
Sequence:
MKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQASWAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFREFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQLVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEECQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI
The following text describes a protein:
Function:
Required for posterior mesoderm formation during embryogenesis. Acts indirectly to suppress head formation by altering mesodermal patterning. Also involved in the establishment of left-right axis asymmetry, acting upstream of nodal/nr-1. Can exert long-range effects in the embryo.
Subcellular Localization:
Secreted.
Sequence:
MVWLRLWAFLHILAIVTLDPELKRREELFLRSLGFSSKPNPVSPPPVPSILWRIFNQRMGSSIQKKKPDLCFVEEFNVPGSVIRVFPDQGRFIIPYSDDIHPTQCLEKRLFFNISAIEKEERVTMGQLELRFSQNTYYGRVFDLRLYRTLQITLKGMGRSKTSRKLLVAQTFRLLHKSLFFNLTEICQSWQDPLKNLGLVLEIFPKKESSWMSTANDECKDIQTFLYTSLLTVTLNPLRCKKPRRKRSYSKLPFTASNICKKRRLYVEFKDVGWQNWVIAPQGYMANYCYGECPYPLTEILNGSNHAILQTLVHSIEPEDIPLPCCVPTKMSPISMLFYDNNDNVVLRHYENMAVDECGCR
The following text describes a protein:
Function:
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Subcellular Localization:
Cytoplasm.
Sequence:
MSELDISIEFEGGLEHDFKAPNGLKEKVPAGMKLEELPALLSKKYLDPSKPTRFLAENGHLLPGILVMINDADSEIDGMDQKLSSGDHITFISTLHGG
The following text describes a protein:
Function:
Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MANTYKSIAVSIIFLLYFSCVSSQQQTKFLNHGFLEANLLKSGSSKIHPSGHLELTNTSMRQIGQAFHGFPIPFLNPNSSNLVSFPTSFVFAITPGPGAPGHGLAFVISPSLDFSGALPSNYLGLFNTSNNGNSLNCILAVEFDTVQAVELNDIDDNHVGIDLNGVISIESTSAEYFDDREAKNISLRLASGKPIRVWIEYNATETMLNVTLAPLDRPKPKLPLLSRKLNLSGIISEENYVGFSAATGTVTSSHFVLGWSFSIEGKASDFDITKLPSLPDPLPPLSPSPSPPVSVMKNSSNTMLIIIIAASAIFGILILSFLAVCFFRRTENFTGGARKFSHQTISSATGGFDNSKLLGEGNSGSFYKGQLAPTEIIAVKRITCNTRQEKTALIAEIDAISKVKQRNLVDLHGYCSKGNEIYLVYEYVINRSLDRFLFSNDLPVLKWVHRFCIIKGIASALQHLHAEVQKPLIHGNVKASNVLLDGELNARLGDYGHGSRHSTTGHVAPELVNTGKATCATDVFEFGVLIMEIVCGRRAIEPTKEPVEISLVNWVLRGVKSGNLLRRCDKRIKKKNLVSEEVLLVLKTGLLCVRRSPEDRPMMKKVLEYLNGTEHLPHDDYVV
The following text describes a protein:
Function:
Transcriptional activator that functions upstream of the let-60/Ras and let-23/EGFR signaling pathways to positively regulate lin-3 expression and thereby promote vulval induction. Plays a role in excretory duct development. Plays a role in male tail development.
Subcellular Localization:
Nucleus.
Sequence:
MDDILSAALAESGLDFLCQQSSPTPSTSGSIHDDAGQSFSNNTHTPSVSQFFDETSNDSHSSSAYYTPMATPFVSTEDGGVPTSFFGMDEEDGGCTIMTTAGTSGSNNIDGIEDAGGGMYYPHVKVIPRKHTAPTVNQSEPSTPTVTIVPKKEDPLFETNTADSPTPSGDTSTTASYEGNDGLEDQETTSDRQNPMFVQTARSTDGRLDTPSTSATVSPHITSSLTQRSHTSSPASSASEGTVVPPRKKGLPITTGSIVKRTVQTKDGLQTQYLKAFVNENGEKIYKLLSPVAASAVARGTLPPGMGRGGSTIGRGGTMVNKNGERLMVVKNHVGPNGQMLVKRMVSPAGTRIVANGGQGRGQPIYRAVDGSNGPTHLLRRTTTTGQPTRGAPVGMAARHAVRGGTVYGGGNGYRVNLVGRGTGGSTMVHHQPLNRISSQRSVAPVGRVLNRGALRNGAQQPLHVSTSSPAFHYMEEQPSPTTNGMVIQAKTPGAGVIQARHMQSQQSFPSGGPARVLMNRSSTNAGLSRMVGGGYDQQLPTAPNGRLMIPSTAVRVPGSGMASPRLQTTPQPLTKSQKAKDEMKMAYQVGREEALQQRRNDLEDDEENLGYAETYSEYTPAKLRSGMAHPDSVVESASLSSVSPPDVKYQISIPEYLIDMGHISALQLEAVIYACQMHERRMPSGERYGYLIGDGAGVGKGRTVACIIFENYLQGRKRAIWLSVSSDLKFDAERDLRDCGAPNIPVYALNKMKYAKISGKENGSIKKGVMFATYTSLIGECRGAKSRKYRSRISQLIQWFGQDYDGVIILDECHRAKNLVPTAGAKPTKTGRMVLELQKALPNARVVYASATGATEPRNMAYMTRLGLWGERQAFPEFHDFISAVERRGVGAMEIVAMDMKQRGLYLARQLSFRGVSFAVQEVQLSSEFVKMYDAAVKLWMEARRQFQTVIETMDEEERSTCKTVWGQFWACHQRFFKYLCIAAKVDTCVQLSREAIKAKKCVVIGLQSTGESATLETLEEMGGELNEFVSTAKTVLYGLIDKHFPTDASFSMGDRDIFKDFDDFERPAKRRKTRETLSFLGDVGFDTWTGVTTGMGGRVGDGVTKNITRGLSGIGRSSMSSSTGNTNNEDANSTTSESSDGSDDEVENDMISENGGESGDLESAREEAEGARTLEDGEQDEWVKALLAEAESSSDDSDEEVVKDEDEDEEAESKSGETHEQEEEFNPFMCDFTNDDPWAHNQQIVEDTPQKDRKAKKRKRDEEEAERLREKVRKREERREKKRRRAIRRAEREKQRRNEELQARGSATDFITSSRICGNGSGEQDDINPMLIKTELLAAVERLAPSLPANTLDQLIDEMGGPEYVAEMTGRRGHMVTSETGDVMYQRRNANAEVSLELINMEEKEKFMRGEKLIAIISEAASSGISLQSDRRAINKRRRVHITLELPWSADKAIQQFGRTHRSNQVSGPEYVFLISELAGEKRFASIVAKRLESLGALTHGDRRATETRDLSQFNMDNKYGRVALDTLLKTVIGQAGTPLIDPPKDYKAGEFFEDMRLYMEGVGLLAKNKTGQYTIEKEAATIPKFLNRILGLPVHAQNSLFHYFSEIVAELIAQSKHDGTYDTGIMDLGTGDDQVRKLETRVFTGRVDNGSFRVEIHKIGVERGVSWEEAMELHKEHSNDDDGFYICHPGGANTANTKKVAALVYGIGKIRMDNGARLYAITRPSTGRSPKLMTMADLSKRFHKVSIDEAKEVWKQQYDSAANMCQHNYVYGKCRTESNGTYCEVGRRTRTYFVLSGSVLSVWPIVEEVLAGSDRKSSRMQVIRVRTEQDQKIVGLLVLPTHVRHLVQQLETHCGRSYVKTEP
The following text describes a protein:
Function:
The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MATSQGIHSISTILKRLEAVTSRLEDIAVTQTSHGSSVKSPAPTPDTPTGVAPPAPETPKSAEMTQPTLSPASKVYQDEIVNGALNDFLSKSKEVGGLVAEHSALIGLLCEAQLSFLQFASNHAKPSAPNALAPLLEPQGKAIEAVMETKDKLSRSKEGREWGVCFNVLGEGVPAWGWVQMEPTPAPYIHEMKNAAQFWSDRVIKQYKETNTSVVAWAKSFIALIAALESYVKEWHVTGVVWNPKGSPAPSSIPKTSTSAPPPPPPPPSSSAQAASTPAASGAAALLADLNRGGAATSGLRKVDSSQMTHKNPSLRSASIVPDNGKKGPPLKPKPGAKPAKKPAKVELEDGNKWIIENQEDNRSIKIDNTELHHTVHIFGCVNSVVQISGKINAVTMAGCKKTSVVLDSAVSSFSITSSPSFEVQIIGSIPTIQVDTTDSGQVYLSKDCMEVIEIITSKSSSINISVPTGEDGDFVERPVPEQMKSRVVDGKLVTEIVEHSG
The following text describes a protein:
Function:
Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway. Has no activity against on Gram-negative bacteria and fungi. Shows some partial redundancy with PRPGP-SA in Gram-positive bacteria recognition. May act by activating the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway. Recognizes S.aureus PGN (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MTWIGLLIVGLTAIAVQGEVPIVTRAEWNAKPPNGAIDSMETPLPRAVIAHTAGGACADDVTCSQHMRNLQNFQMSKQKFSDIGYHYLIGGNGKVYEGRSPSQRGAFAGPNNDGSLGIAFIGNFEKQAPNKEALDAAKELLEQAVKQAQLVEGYKLLGHRQVSATMSPGEALYALIQQWPNWSEEM
The following text describes a protein:
Function:
Involved in signal transduction through the Wnt pathway.
Subcellular Localization:
Nucleus.
Sequence:
MAGQQQQGKRGKGSQMKSPEKKKRKSNSQGAAFSHLSEFAPPPTPMVDHLVASNPFDDDFGPPSRSAGGGGPGGATFLPSPGAGGGGYGGPGRMGGGMGFMGGPGGPGSGQPGRRPPFGPPTPNTGPHHPLGFGGMPGFGGGGGGGGGGGGGFPPGGPSQFNMPPNFSPPMHPGQGFNPMLSPGAMGGGPGGGGGPPHPRFGMPQQQPPHGQGGHPFNSPPLPGGPGPRGPPHGPMNPMGGMGGGMNMMGMGGGGGGGNMVGGHPGMPPQGQFPPPQDGPYPGSSPPVGEEGKNFGGPGGGPPVPSQQQPPNLNPSGPPSNNATPGPSPAPGHPQPGGGFPQDVPQPNPNTPGQPQSVPQPPNPNSSPTGPLNGPQPQAPNNQHPPPNSTGGPGPNTPSNQQQPTPPNSAPGSTPYSQQNNTPGGPMPNQPPNSNQNNLNNNSSGSNTPGSNPNPPSNSNSTPNTQSPLPSGPAPPSSGPGSGPPKLGGGMVFPCGLCMSEVHDDQEAILCEASCQRWFHRDCTGLTEPAYGLLTRESAAVWACDFCLKTKEIQAVYVRQGLGQLVAANDG
The following text describes a protein:
Function:
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Domain:
The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.
Sequence:
MKGVENTLSQSESVNRGYNGWMGMESETSARATHSSEQMISLEEYVREMLPMHLQKLLMERIIEAEQTGAAHTSVFAAPTGVAAQYPAMGPPMLPGQTFSSRSFAEGLVVGQLSVIVVLIFFIKFFIFSDGPAKTGGGGGSSAESRSSGFTGSPLTSTTSRLLSTLIKRGGKEGTEFAEDSENERTRQINAILEKTYYDVETHSPESLDWFNVLIAQTIQKFREEALQKDNIVHSLNDFISRKSSQLPNYLDAVKITELDIGDDFPIFSNCRIKYSPPLNKKRLEAKIDIDLSDRLTLGIETRLLMNYPKYLTASLPVKLTVSMLRFQACLTVSLTTAEEFVPTMAATTDTDAGDSEGHYLVFSFSPDYRMEFDIKSLIGARSKLENIPKISSLVEYQIKKWFMDRCVEPRFQFVKLPSMWPRSKNTREEKSDMQEEDPSRAPE
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.
Sequence:
MASTPPARVPIPKNGVDYRGTVVLAPMVRSGELPSRLLALKYGADLVWGPETIDRAIIGTTRRMNPHTNTLEWSRLPTSKLKNPALDPENRESVLYRIHPELEKGKLIYQMGTANPELAVKAAKMVAADVAGIDVNSGCPKPFSTAGGMGAALLKTPDLLCNILTSLVEEVGKPYEIGISVKIRILDTPEETAALVSRLVKTGITGLTVHCRTTPMRPRERAIRHQLKMIGNICREAGVACVMNGDVTSRTEALKLMEEFNVDGAMIATEAEKNPSCFRSDAEGGPHEWRSQWKTVVTEYMRFALMVENRWGNTKYLLGQMIPGRDKCYQAMNKSRCYTDVIGALGLEGVEGMLEHAKTVDAHLGIPPQETNAAKKARVREMNKQNAQAKEQKEKRKEPHDEQPEAKRVKAAEPPVERPAEVEAPVALQPEAATPAPAALSV
The following text describes a protein:
Function:
Starch-associated phosphoglucan phosphatase that selectively dephosphorylates the glucan C3 position. Probably participates in the regulation of starch degradation.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MSVIGSKSCIFSVARYTRENEKSSCFTSINKKSSLDLRFPRNLAGVSCKFSGENPGTNGVSLSSKNKMEDYNTAMKRLMRSPYEYHHDLGMNYTLIRDELIVGSQPQKPEDIDHLKQEQNVAYILNLQQDKDIEYWGIDLDSIVRRCKELGIRHMRRPAKDFDPLSLRSQLPKAVSSLEWAVSEGKGRVYVHCSAGLGRAPGVSIAYMYWFCDMNLNTAYDTLVSKRPCGPNKGAIRGATYDLAKNDPWKEPFESLPENAFEDIADWERKLIQERVRALRGT
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MSRISHPKRKIEDTIWAASKRLQNYRSRRRRRKYKKSAGGASEKTETESVKNQMFDSADASDIFLENFDVMCDKKDDEDEEDVELQQILFFSAQFHSGKNLNLGLCSKVQGKQVINTRYSVIYGSISTVNSIREKGESSCTYCEICDDAKPPNTLIRGSSCRHYYCEECIRNYIGEKIDEDIKELKCPVSSCKRILDIESLMPKDFLDRVKDAIRETEVLASPLVIECPFLDCTGVLIDDKKRFLIRACPKCWRIFCVMCRDSWHMGMSCVDYKLQLNNIDRQLSLFLWGLRDDDDEEDDTGKGNSLIKIFL