The following text describes a protein:
Function:
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Is recruited to DNA ends by the Ku70/Ku80 heterodimer and is involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (By similarity). This activity is only apparent when DNA damage is administered in G1 phase of the cell cycle. Required for efficient signaling of DNA double-stranded breaks via phosphorylation of H2AX during G1.
Subcellular Localization:
Nucleus. Nucleus, nucleolus.
Sequence:
MDNIYQRIENYLIKLFQTISETNNNNNNNNTNNNVGIKFENDLLLVNELGSIILKELVLEEEIGLVASLLFTGDHSLLKYLEKSSTISNKENVKIKVSILNLIAEFIEILQVRTDDYAIAIKNTCVLVFRKDQSHSVQAAAFGPIKKILHLMSRVLKQGSIVAESFGVSEMTQLFLLQFTCGKLTQTVRGEIIVVLGLFTEYFSSNMCDRNQQLSFIFMETLGGQLRSKSPESTLIQSCLKGLNSLLVHFSGDFIASDPKNVQLIYQYVYICLDPASSTQRFEIPRAAMKIVARHAVLLRQYLAEHSQPFYTRIEHWCNHINKLNRDIAFTAVDSFFQQISKELTSGNRSLEADQSTFKFFIRKFYSIFENNNSSRFELSIAIRGCGRFASPVKSFMGEWELKSLLNSLFKFSEKLMVVKIENIDEITLHLSSFINAFACILYELNELEFWYLDHIEQVLETYFIIFPHLFVKSRDRYFKAVNRLISSLFYHGEYLKILLSRFVKKGLLITFSKPNDSIKNLITTANTPFYQVYKDLWYNLLNPTIDTIDKDLNSTIKKENNNNNNNKNKNNNNNQTLTKEEISKSIKKLVYDEIVSSILSIIKKLDLQYQKDENDNNSNSNSNNNNNNDQDNNKISIIEYESEINQLKPVTSKDIELFLGLVEFFKLFISKYNTELFVQWIYIFGKEMISFSKKYPLISGFYKLVQIVMQICKSQKYFNELQQDDNINSVIFNNQIIDEQLQQQQDIMDIDDTDNNSNSNNKINKKLTNSLEEDKNNCFILFKKYIKEVSNFISHYKDELLSSCIELLLSLPKQLISIPLLVPIANLAFQYGISYLPLAHVGLNAIEYWNLVVPDQVHKHLDQLLPSLNDYLKISTNSSDSTSGGDIDIDSGGSMGGGGVVPPPSSSSRHRKMKFKSNSSLIDPKQLQFKTSIEDLQNRIIRLLGQLGGDNVHFLGKVSLVGEEIVNGVAWDTEPKVLIKIPFADQNNIDIYLDVILPNVVNLAEKSPNRQIKVAAGELLHSVLLMMIGNSANQSQANQISYSRLYRKIFPSLICLSTDVEQVTKQLFQPLVFQMIHWFTRNKKQESDDTMNLLNAIVDAVGNPLDGARRDFAGQCLCEFAKWSLKNTSVKQQEKNAFNFKSILKRIYSLAHHPDPYKRLGAAISFNQLYRIFREEDSLVDQFIFEILHNIFFSLRIGDDLTNTSSSKNNSNSNSNNNNNNNNNSEDGTEDSIVEIASKYSNVLAALTKVIIKRADMLNKPSNTRREHKDLSQFVQWVFQNGCSRTESIVRYESMILFTQLVTLLPNIKTPLQWVKERIKSNGIQFIVSIAEQQGGGVGGGSSNGNTSLGRIPKIEIGKHKDIEFWFRNLSTSLNIYLWFFSEGFFEPIQILTSREFKSSLLSSAFHTFTTQFSMLNFNSNLKTNQQQQQQQVSMFSSMTPKEIDQFNRLKCNVITNLFGLYILLLEKYKFEQVIDYGGVAFVQLLVKCLMDPQSVGFVNNYLEEREVELSKSSRQDIRNLMSRTFKFPPLLEIINNIIKLLIQIKPKYNDILHKELMEYILPNNSNNNNNSSSSGNNKSMFSLIDIRQLINTEGTDRLIHLIHSYQILYKYNLLDSILLENYNEQSEQGIQDLPKSSLEFSEFIFDYLFNNCENLSPSKLLISKELIQLALTIGIKPIKLLSLIINPNVQNTTTTTTTTSTTTTTTTTTTSTNNNNDNNNEFIKDIHDIFYKTLFTEINNYISNNFQLFLPLLANRIIETNQIHKVLNDVCIMKQQQQPNRGFKDIIESIVLFLNSISEWTLNSNLKLVEKENIIEFTKNLIKIDPIQFFENKHCYEFVYNIITNYLCRSNPLTFKNKVLVLLPYLLSYPKHNNFDLIKQKLNEIVVYDFPLNSKDLTVKSPIYNEYITCIERLLETFELTKNPLVIDTLLHVLKETDHTHINYINLSIERSILSTNDIEAKEIFSHCFELFLNHYDELKITLIDKFCVPLISHMKENILVQIFSQHLSSLMSIIQPLQPKYLSDSQERKSSIIEKICCFHLIEALYQSLPSAIIKEKINPFFYDKPDGKGTELTAAIMKAAHSAKSEKLTSDDKYVTRSLCTKYHGAAFSALASVIVSTQTKENFFHVFFFKENKDKNEYLWENIIDTDQVFNFQPETNFLVSYSTPQSLFANDLRYLSSQYLVDSSLSQDFIAKNFLEGDNNSTTNNNNGDDGIIMQGQSQSGDNENQISNDIEIDQVNSNPSMIAMLKIIDFYQKKFVVTPPSSILFGQQSQQPKPTVGDMPKWMFEIYQKLQQGVHPNIVIFMIKIIINRPQYFERFHELWIPILMDYVVSEGNGGNGLHYFVRDVCFILLKWPNIYKSQDGGGGTTLEKHLSKFVNHLMKNTYCTDRRILKSNLNIVKSFVERWKSLFKVDKSIILELLSTKGDFKSKSRQIKTTGLVLLSILLSNGYPAYDKEYDSNTISEFKFYQVLLDHLQDFKELYDAASEVCGMILLYLSKQQQSQQQQQQSIFPQLLKDKINSILNNNENQRAFSCLYFIGLHYPLFLQGFYGKIFNLLPQISNETRLIALNIIHWCVEDIQDLYTKLKSNNIENLIRIREGEIQVVILRILYKLVQKRDTTFGTVNQILSLLLSNNWFTSNVTNEYSRSLYYDIIIYIYNNFIEYQDQSNENSKDLVLSLLIGLSDESDSINKKLLQFWDNNSKTLSASSNQRLQQFFDIMYSPETESKWVANSCCLLFQLCNRSSDFTKLLFDKPLSECTFKEVQVDSSWQHRTLNMNPLFSSSQYGIDDATTDESNGDSMQLDEIRATQAPNFTLTQTAFSEFYPSSSQSYGGTNNNTGSSQLSSSSSSSGSQSSSQNNSSSKRKQKITNDPKLINNSELRRRFKKIDDRGADERIVKFARLQVKRNIEREAYFEKSKQARENQITMIRKYRVGELPDIQIKLQDIIKPLQLLCQRDSTIGVNVFSSLFTALYKNTPKESIRTFQCNIKKLIDSIVERCKFNSTLVSSILNISEKNLEFSPEFSKIKDISLNSNNHPMAIILCEKLILSLQNTTKASTTNQAQKLQQQQQLNQGWDSLRELYKSLKEDDIIMGLIEKQMGGDIPYTKKALEFELKGDWVNVLKVYDEATSKLESGELNQYQGNLSESETALWENGRLECFTKLCNWSALKDNFNSYYPNPNQIFKEKNCDLLLSYFFEFNLKVKENWNYLYQFIADLANTKQYQYLENKFPGELAFLEVTRSDHNKASYYVSKFYQAFKHQWSSSHPLAIESRHRILQPLQKIVEVEEFLNLTSTPIINTLKLDTLLTQWKSRFPTKLDDIMVWDDLIFYRSVLLEKIYERFSSFTSDKSSDEKVKSTLIQERAILYHKMSKGARKLGNIVVSEIYFRQAVKSYPKTKDNDLAFPLVTSLIDIYCTKARNSPSPIETLDRFVKALKFIESKKDEESIINSNENLQKYLMMHGDIFWDIYQLDKKLGSTLVIDSFKKNSLPINLTSIPINSLKDELFNSTFKCYSESIKLHQKSTNLLNTTSSSPSLSISSSSSPYSSTSSSSQPKLSNEILIEKTKTKSAHLKFANFCDNILKDKISQQTTPTQFNEEVIDLATSVIVSTLEAIKEEIPGSVDKFPRLLEILTQFEQYSVIAREFKSRVSTIPCWMFIRWISQMFPYLDLPQGPLILPILLEIAKWYPQAIYFPFKISSEQFGPLAKKISAPLEKELINPLLDTLVIEFQRLTHPEHRFKDYMEEMKSLIKATPKDLNAIAKLNNEIYDDSFNPSTVSGDYNLKFAKEHEASYLSNFGKDSTKLARMDQKKFLEIFAEMSGNMNKNMKPNSTASMKLKDFSGWLADFDRSNYQTSHQMEIPGQYDGIGKPQPETHVTISSFDTNVLVMGSLRKPKRVKIHGNDELDYPFLIKGGEDLRLDQRIQQLFGIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEWLNDTKPLREILEEQLAHQLKTPRSNVSISKLESTKYHNDWINSFAKYLKPNSPVGPLYQQMFIHATRDDCAKKLEKQHSKVPENLLQNGIWSLSSSPESYLFIRNSFARSLASFSVCSYVIGIGDRHLENFLISQRDGRLIGIDFGHAFGTATQFLPIPELMPFRLTRQFTSFLRPLDSVGLLNHNMTYTLTALQNQKEILLTTMDVFVKEPLLDWSKLATRLVKEQGKHPKDTKNVWFPKQKIQIAKKKLELVNPAYITLEELSGSVHSGLPYEKALSEIIKGDPKHNIRAKVNKVCSSVKEQIDCLIDQSTDPNILSRAWVGWNGAL