lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable cuticular collagen-like protein (Probable). Nematode cuticles are composed largely of collagen-like proteins (Probable). The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (Probable). Acts downstream of the Wnt signaling pathway; perhaps in the formation of the adult cuticle. Required for proper strut formation within the unique medial layer of the adult cuticle (Ref.2).
Subcellular Localization:
Nucleus.
Sequence:
MVKSYTLAGLAAIACLLLAIGAVISTVYILNDISDFYSEAQEELVEFKDIANNIWEEMVFELTPEEMREAEDNDREKRSYEPEGPYQSETTTPSTTTSTAATTTEAAEDESGYDFVNDNGPPSSRPRKPEPPTMPRTIQGFRAPPPAATSTYRPPHGSNYDNYGREPASSRRPYPPQQPPSTSAPHSSPNNRTSLYNPQPPPKTGYPTNPRVPYNPPQPNYTRQPTYPEDNRAPYKPTRSPNTPPPRQPSGGYDSDGQTPPSSPRIYNTRRPNNHGPGYPEDQVPTAPPVPGQQRVPPTQTRNPPNPTNTRQPSRPVPPTSDGHIEATTPYNPSAQYPTGKRGSHPGFGPQRPRPGTRPRGNPCDQCSAQPNHCPSGPPGPRGRPGPPGFPGQDGPRGLRGLNGGYSGVQPSSYDPVIGCVQCPIGPPGERGPDGTPGVPGEDGIDGEQGVNGQDGQPGAPGAPGYHGMNGSPGTPGKPGLPGRNGQSCKSIPGPPGQPGVMGVPGRDGDPGTDGEHGQDGSPGIQGPPGRDGTSGPDGQPGVSAPGAPGTDGGYCPCPKRSSKFDFNDAYNDDEKRGLEEHRPRGYDSERAEEPRPRQTVRTNTYDENSGAEHQRRPNYEPSAEVAPPRQDRYEDEERVREPPPKRPPPPHRQTPHELYPEEQPYVRRPPPPQNRGNYEVERSREYVPEAPRPRQGYEHSSGYGGDDRKEQPKYMESRPVDEPRYETDAPSRSRPLKKVEIIRHPERGYDRRQPSYEDSKPRQEEPRRYETEAEPRYEEVPRKETHPPGFGRPKSEENPRETGRTYSEEAMPPVQQTEKYNGDKRKKNQPEYEDISKPEEDKERAMEKHHKKPNKFQEKQWEEHRKSQELRNSREHGGQVPVETSVPMQQVKPESSAEEKPVPPVHDNFQSSEKRAFSNENPLPSEQIPYRRRNRFYRNHYYEKFLV
The following text describes a protein:
Function:
Required for plastidial pyruvate kinase activity. Involved in seed oil accumulation, embryo development and seed storage compounds mobilization upon germination.
Subcellular Localization:
Plastid, chloroplast stroma. Mitochondrion.
Sequence:
MAQVVATRSIQGSMLSPNGGSVSTRSEKLLKPASFAVKVLGNEAKRSGRVSVRSRRVVDTTVRSARVETEVIPVSPEDVPNREEQLERLLEMQQFGDTSVGMWSKPTVRRKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKDNTIAIMLDTKGPEVRSGDLPQPIMLDPGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMSEMFAYHATMMSNTLGTSTVVFTRTGFMAILLSHYRPSGTIYAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIVQSGTQPIWRSQSTHNIQVRKV
The following text describes a protein:
Function:
Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQVKRQGAQVTTERTVQLNVSYAPQNLAISIFFRNGTGTALRILSNGMSVPIQEGQSLFLACTVDSNPPASLSWFREGKALNPSQTSMSGTLELPNIGAREGGEFTCRVQHPLGSQHLSFILSVQRSSSSCICVTEKQQGSWPLVLTLIRGALMGAGFLLTYGLTWIYYTRCGGPQQSRAERPG
The following text describes a protein:
Function:
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
Sequence:
MSGSAPSIPNLLTLRGRIGGGGVTRGRYRGVIHRGGRGHGPGAPSASAAHDATIQGTDTDAAVSRLSAVQIGYIDDPYAELFAQSGPGAARRLPIINRGTYARTTAIDKLVDKFLDDTESSPEGRQIVSLGAGTDTRSLRLFSPSAPTPRKRVIYHEIDFPAMCEKKQRIVCSAPQLRSILSDPDSVEELSQHGGGNSWHSKAVAEKHKGSELWVHGLDLRAIAASQQPQQPLPPGVPIGSRGLHASPFTPGSTTQHEEQTEETSLPQQREPLTLTSLNPNLPTLIISECCLCYLPPSTASSIVSFFTTTIQSSLSIVIYEPIKPDDAFGKMMVSNLAAREIRMPTLEVYKEAEDQERRLREAGFSGGEGKGIGGARSKTIEQIWEEWTSQEEKERVDALEGLDEVEEWKLLAGHYIVVWGWRGVGVDLEI
The following text describes a protein:
Function:
Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass type I membrane protein.
Sequence:
MWGSLCKAPLLRLRPTFAAVSNVKTIHIKASPDYNEGIDKSKPLKFSTSKASHRHWTVAKSLGSNQQRPWWKVVPLSVFLTTVLLWAIFRKETDIDEAIYKPIEQLQDESENK
The following text describes a protein:
Function:
Shows a 3'-5' exoribonuclease activity.
Sequence:
MKKKIAEYEVGEQVDIFLLIKTATKGIASNGKPFLTVILQDPSGDIEAKLWDVSPEVEKQYVAETIVKVAGDILNYKGRIQLRVKQIRVANENEVTDISDFVEKAPVKKEDMVEKITQYIFEMRNPNIQRLTRHLLNKHQNEFLDYPAATKNHHEFVSGLAYHVVSMLDLAKAISNLYPSLDKDLLYAGVILHDLGKVIELSGPISTTYTLEGNLLGHISIMVNEIGKAADELQIDAEEVLILQHIVLSHHGKAEWGSPKPPLVKEAEILHYIDNLDAKMNMMDRALGRTKPGEYTERVFALDNRSFYKPSFHN
The following text describes a protein:
Function:
Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate. PIK1 is part of a nuclear phosphoinositide cycle and could control cytokinesis through the actin cytoskeleton (By similarity).
Subcellular Localization:
Golgi apparatus. Nucleus.
Sequence:
MPSSNSGNELLLRFFESAHFTSQLCVAYLSRYPNNIGIHHFLCEKLATFPYEEIEFFIPQLIHLVLNKDSESVALEEFIISQCEQNTQCALITFWYLQAHMVDLGLQPHSSCFKICKRLYNRIQILVFMSSSSLIQSQQKISENVTPALILSGIMLGGVCVPELLKKAGPIAIAQGRKAPRQDPDESDVDVLRRLSTEPRYSLDVLRSSLNNSIVEQHSEVSLRLKAPELTRTHSYQSSATLSIDEQRRVLRSNYFQQEIQFLFALQDISIRLIIVPRQARLSSLRAELALLNNNLPADVNIPLLRSYHKEVSHKIVRIDPKEATILNSAERVPYLIMVEVLSGELSFEPQSKKNKAKVQKIVSHKNQRKRWFDLTDVDPYTNLQDSTDNDISESESEGGDLSMSPLIKGLVPDTLSLSKSFSSFGNVSLQVPSSHRDTDVVLLSGRHSDSDGNGALKRSKIYASEITARMRAAATMLSQLDAEGSRRPKAETERIKNSIILDMQRLEEERLNEPSIYPVSVDISCAEDLRFGKETQKAERKGDRDDPSAATFQEDWYAKKERIRKSSPYGHYPNWDLVSVIVKTGADLRQETFACQLIYAFQRVWLECKEKVWVRRMKILVTGDNSGLIETITNAISVHSIKKNLTKQLREAELAQGKIAGKNVVTLKDYFIKQFGDPNSSRYRQAQTNFLQSLVAYSIISYLLQLKDRHNGNVLIDSEGHIIHIDFGFLLTNTPGNVGFESAPFKLTADYLEILDDRFDEYRSLMKAAFKSVRKNADQIILLVEVMQNNSTMPCFRAGENTSAQLLQRFQLQLGDKECDDFVDLLIQKANCSVWTRLYDLFQNITNGIY
The following text describes a protein:
Function:
Phosphorylates PPP1C, phosphorylase b and CFTR.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEALLGGGVCFLGFVTLTHAAPVSNTLSAEAAGYVDVSLSIPLLLSLAVTLALVVLLLNCASCCKEQEINFKEFEDHFEDEVDFTPPAEDTPSMQSPAEVYTLAVPPVHLPGPPHLQLPRITDVSSGPHVARHSLSYIQEIGNGWFGKVLLSEIYVDPGVARAVVRELKANASSKEQNEFLQQGDPYRVLQHPNILQCLGQCVEAIPFLLVFEYCELGDLKSYVSQHEWLYRNGELLQLQKMACEIAAGVTHMHKHNFLHSDLALRNCFLTTDLTVKVGDYGIGPTNFKEDYITTEDDQCVALRWLSPELIGELHGGLITSEQTKPSNVWALGVTIWELFECAKQPYHHLSDREVLHHVLKDQQVRLLKPQLDLPYSERWYEVLQFCWLPADKRATAEEVHRLLTYLRMQGQKDVEDDFEQRWSSLKPNPSTRQATVSHSSFPILEQFDDGREPDEVLTVTETSRGLSFEYVWEAAKHDHYDSHNRSAMDTTLNYHSMFFPVPRQDIQAHFPDTTAQAADGGRVPETLPVFDAHKASSGNDYFIKLEELDESEIGMGDSQGAEGTNTSEQNQYVVLQDVRLDESSTDADFFHQSIDSKDSFLQDSHIWSSSEHDSPYHTNIFSEGDAKMEDSHSFEGGFMELPEMMNLPKRDSDEANGKEASFQTSFLGVGPEAIHLEISDQGSSDVMKLLNTEKLSDNFMFLKDNSLMKDKSEVSPPDSINIKRSIIETNVSDSVNLTGESLKSAGSSAQLKDEFLDLVSPILDDFLSPLKGREAMVPFDILVTGSNRLPDTNGSLRSPKSRNYSSSESTSESVEVIVDSPSDSHQSLESATTDTLQMCIDAKPPSLEECFVASKDNGQHIGISDAAELSFTTSPVGEYTELGLTEGLTSSDSMSDIMETAKDIPPSEAIDQDTLLDNHATQDMSSLLVLDSCLDQISQDSLLDDSTSSTLPTIENSAETPDSLDSLDVAHGQSLDISVNKLQPPYKAADSGYETENLESPEWNSQTGLKDEDNDAAVEPSALVPPEIVVSEVDSVPDVQVNAGGVDHQQEPGEFPLGGNYRDSAYFSDNEELDKKSDDVSGNGSSIWLQNNQETNESRVARALEEHSRSETSSQSAGPTVESTITATKTLVPELVLTTEEDWSKEKPLTVDDSNQNHPCDVPETPTTSLPPPTEVMLHAKLTRTYAGEGTKKKEPDMEGRYLGKLDGSYGTEDGMDADEEDENSDDSDEDMRAYRLHSSSSECSEDEVVHPVPIIISDNSSSLNLKSLLKPKTLQTAKATSEEGRDGDSRRGVSFFDDVTVYLFDQETPTKELSEHTLDPSSQLSDFSSPVASSSYLNRFTNSESSTDEEGGAFEWDDDFPSPEPNFLSKAASDHSSSRSSGTSAASKYFSPPPANRSLDQSWTSPSSYSRFSISPASIASFSLTHLTDSDMEQGGSGEDGEKD
The following text describes a protein:
Function:
Involved in rRNA processing and ribosome maturation. May also act as a transcription factor (Probable).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPAAVATGVQFGGPPKNKKIVFDDSGEAVVKQNKKEHPQRPKFEGKEQVKKPQKIKFGEDGKAKGAKSFNKNHQKPDFANKPQRIKFGDDGEQVASKSFNQNHKNGPKPQKIKFGEDREAVHQKPFNKNNHKHNGQKSDFANKPQKIKFTDDGEDEVTANSSNTKTEPTKKSQKIKFGDDGESKENFKKPQRIKFDEDGAGKNVSDSDGDSDEELGDSISKKHNKYQSKIDEDEESQKKWYHVHPDYPSTDEVLDMKENDQLELYNLCKNSFEAEKITFNKRNPSDARWLQTALHKGTAKDRANAGALLVTSNPLGNLEALSTLIGFCKISNKASNDVIAVLTDLWQEVLLPPNRKLLAVHTRGADWKKLKKDENLRNEQKRRIYAYWHFESELKDQYHEFLKNVMQGLQTGQEHNKNSSIVSAARLLAYAPEKEQLLLTMLVNKLGDPIAKIASKALHHLSEVAQKHPNMCGVIVAEAEKLLFRNNISERAQHFALCFLSSIAPSGRPEVCTKLVNICFALFKVLVQKGAVNNRTMQAILRCLQKAIVEAKPAKDSNGELLTKEMQDTIYRLVHLADIRVAVQTLGLLLQLVAVKTEKSDRFYNALYVKLLDLNLINVGSKTAAHLLHIVHRAIHIDNHVARAQAFVKRLLQLTLYAPPHIAAGCLIVIHKLLRMRRELIGGTGASEEVEEGSKVVLPISADLDKFGSDDEEVYEDVKDEADDTKDSNPLEEKADNDVKSSASSWHHARVAATEAKVRDIDSCKYDPYHRVPAFAGAAYALRHELLLLRQHYHPTVQVFAEQILQQSRIDYYGDPLRDFGLPHFLERFAFKNPKKLEASQAAENATVAHKRYMAHGARGRPVKSLTKANCTEDEMFIFNFLEHKRRQAEIVAQNKKQKEIKKDAAEEGDDGEAGEEYLKEGEVDDDEFEAYLDGYFGKKFKEGVDEEQDEEELNFLQELGGEIKKDKSKDKKKKKQSDKAEDEMDDIDDDWGDDDLAEDEDDEIEGEDQSDDETGSIDLQPLDDDDDDDDDDDDEGSISEGGPGDSDSSDAPESPDEEDDDDEDAPPRSKKSRKDSTDMVGGRSFAKTLKQSHDMSSLFAAADDFSSLLEETAKVKGQGTSNAVFNKDKSSDKQLKWEENRRSNSKSYKGKKFAGKPAAKGGRPQKAGKKRKH
The following text describes a protein:
Function:
Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria (By similarity).
Subcellular Localization:
[Lys-gingipain catalytic subunit]: Secreted.
Sequence:
MRKLLLLIAASLLGVGLYAQSAKIKLDAPTTRTTCTNNSFKQFDASFSFNEVELTKVETKGGTFASVSIPGAFPTGEVGSPEVPAVRKLIAVPVGATPVVRVKSFTEQVYSLNQYGSEKLMPHQPSMSKSDDPEKVPFVYNAAAYARKGFVGQELTQVEMLGTMRGVRIAALTINPVQYDVVANQLKVRNNIEIEVSFQGADEVATQRLYDASFSPYFETAYKQLFNRDVYTDHGDLYNTPVRMLVVAGAKFKEALKPWLTWKAQKGFYLDVHYTDEAEVGTTNASIKAFIHKKYNDGLAASAAPVFLALVGDTDVISGEKGKKTKKVTDLYYSAVDGDYFPEMYTFRMSASSPEELTNIIDKVLMYEKATMPDKSYLEKALLIAGADSYWNPKIGQQTIKYAVQYYYNQDHGYTDVYSYPKAPYTGCYSHLNTGVGFANYTAHGSETSWADPSLTATQVKALTNKDKYFLAIGNCCVTAQFDYPQPCFGEVMTRVKEKGAYAYIGSSPNSYWGEDYYWSVGANAVFGVQPTFEGTSMGSYDATFLEDSYNTVNSIMWAGNLAATHAGNIGNITHIGAHYYWEAYHVLGDGSVMPYRAMPKTNTYTLPASLPQNQASYSIQASAGSYVAISKDGVLYGTGVANASGVATVNMTKQITENGNYDVVITRSNYLPVIKQIQAGEPSPYQPVSNLTATTQGQKVTLKWDAPSAKKAEASREVKRIGDGLFVTIEPANDVRANEAKVVLAADNVWGDNTGYQFLLDADHNTFGSVIPATGPLFTGTASSNLYSANFEYLIPANADPVVTTQNIIVTGQGEVVIPGGVYDYCITNPEPASGKMWIAGDGGNQPARYDDFTFEAGKKYTFTMRRAGMGDGTDMEVEDDSPASYTYTVYRDGTKIQEGLTATTFEEDGVAAGNHEYCVEVKYTAGVSPKVCKDVTVEGSNEFAPVQNLTGSAVGQKVTLKWDAPNGTPNPNPNPNPGTTTLSESFENGIPASWKTIDADGDGHGWKPGNAPGIAGYNSNGCVYSESFGLGGIGVLTPDNYLITPALDLPNGGKLTFWVCAQDANYASEHYAVYASSTGNDASNFTNALLEETITAKGVRSPEAIRGRIQGTWRQKTVDLPAGTKYVAFRHFQSTDMFYIDLDEVEIKANGKRADFTETFESSTHGEAPAEWTTIDADGDGQDWLCLSSGQLDWLTAHGGTNVVASFSWNGMALNPDNYLISKDVTGATKVKYYYAVNDGFPGDHYAVMISKTGTNAGDFTVVFEETPNGINKGGARFGLSTEANGAKPQSVWIERTVDLPAGTKYVAFRHYNCSDLNYILLDDIQFTMGGSPTPTDYTYTVYRDGTKIKEGLTETTFEEDGVATGNHEYCVEVKYTAGVSPKVCVNVTINPTQFNPVKNLKAQPDGGDVVLKWEAPSGKRGELLNEDFEGDAIPTGWTALDADGDGNNWDITLNEFTRGERHVLSPLRASNVAISYSSLLQGQEYLPLTPNNFLITPKVEGAKKITYKVGSPGLPQWSHDHYALCISKSGTAAADFEVIFEETMTYTQGGANLTREKDLPAGTKYVAFRHYNCTDVLGIMIDDVVITGEGEGPSYTYTVYRDGTKIQEGLTETTYRDAGMSAQSHEYCVEVKYAAGVSPKVCVDYIPDGVADVTAQKPYTLTVVGKTITVTCQGEAMIYDMNGRRLAAGRNTVVYTAQGGYYAVMVVVDGKSYVEKLAIK
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MATTIDARALAAPLVEALLTTAAEQIRAAAPRIAGLSASEAAAVLPADLLPQVRNFLLTMAKEGLTGELNAVAAALPGYLETGSRAVDASVTSAIELSAEQKERITRELQQRYGDVHVTYHVDPTLIGGLIIRVGDQVLDNSLRARLSAIQRVLQAS
The following text describes a protein:
Function:
Orphan receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSVIPSSRPVSTLAPDNDFREIHNWTELLHLFNQTFSDCHMELNENTKQVVLFVFYLAIFVVGLVENVLVICVNCRRSGRVGMLNLYILNMAVADLGIILSLPVWMLEVMLEYTWLWGSFSCRFIHYFYLANMYSSIFFLTCLSIDRYVTLTNTSPSWQRHQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLDGSEPMCLFLAPFETYSAWALAVALSATILGFLLPFPLIAVFNILSACRLRRQGQTESRRHCLLMWAYIVVFVICWLPYHVTMLLLTLHTTHIFLHCNLVNFLYFFYEIIDCFSMLHCVANPILYNFLSPSFRGRLLSLVVRYLPKEQARAAGGRASSSSSTQHSIIITKEGSLPLQRICTPTPSETCRPPLCLRTPHLHSAIP
The following text describes a protein:
Function:
DNA replication licensing factor, required for pre-replication complex assembly. Faithful duplication of the genetic material requires 'once per cell cycle' DNA replication initiation and elongation. Central to this control is the tightly regulated formation of prereplicative complexes (preRCs) at future origins of DNA replication. Required for the recruitment of the MCM helicase complex to the replication origins.
Subcellular Localization:
Nucleus. Note=Present in the nucleus after mitosis when DNA licensing takes place.
Sequence:
MKCRALYSHDNNILIFGFCVQIMSAGSQTKLNFSVRKTRSSSKRSNAAIIEPPKNPEDSQIIPAVKRLKENLDTESLEQNEVLPPVKNESVLFLEKVFNAVDICVKFHLSINTKPTFVLLENKVSGLTKISLKITHLAQILTVWPESFAITPCFTIHQGKRVATYELSYPRNANLPEAFSRSIEFKRRLEKWLLEHCSETEIPAQQLQALPSLSKNTVNESSLVRKLNLEKSTSRELRIPTQTLEPKFTTNTAKYANELVSCSMLDSSSTLSKSVNSKINLKSHQSSSSVQNSSRKLTSSQLTLRQSSLFDRVRKKQKAMEAKKAEEFKNNLVVHTLAKEKVSFVRIIDLIFVQLSTWPTKRSFSMSEIVTSMQMSISSSLSPDQCAKAIELLSKALPAWCTINLLGNIQVVTFSRIVNGKPYLRSQLIEELQTKASITILSNS
The following text describes a protein:
Function:
Cell surface protein required for proper cell wall integrity and for the correct assembly of the mannoprotein outer layer of the cell wall.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall. Note=Mostly targeted to the plasma membrane.
Sequence:
MQIKSFLLPIVAALLTSVSAADSSNKCSFSKTSITEATAITQLNACSTLDGEITVSGSGIGSIDLSSVKVLKAKLSILNSPSIVSLNFNQLQNITGALVINNATQLNSIDLTQLTNVETLQLVSLPSFAILNLNQGVQKAGTIVLSDTALTNLNGLASFNTIDSININNNKNISKIEFNDLQTVTDSLILSFNNDDAEVKLDSLKWAGNLTIQDVSSIQASNLTSVNGSLLISYNTFDELEFPNLKSVGNSMQIFAHDELTKISFPKLSELDGELEMFNNTQLEEIDFGNLTTIKGAVTISGPFDNLTMENLKLVSGDFQVNSTSDKFDCSAFDKLHEKGKIEGHNYVCTHPANPSSSSKSGSSTQTGKSDSKSSDGSSSSNSSSSSKKGASNVLVVPGMVLTTALGVLLALI
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MACLRAAIAALLLVTLASSAAAAKTKFNITEVLDESPEFSTFNSLLSKTNLVEEINKRQTITVLVVDNSAASAITSLPTDTQKKVLAVQVILDYYDPMKLEGIEKRTALLTTLFQTTGAATDRAGLVNYTHSADDQMAFGSAEPGAPLSSQLVKVVACRPYNLSVMQVSAAIIPPSISSSDKGSSGPPGKAHGSSSNASVPTITDAETLQSFDEASAADDDGLSPSGGGPTTADAAASSPPVHSADAAAGAHTSVGNTVVVRTRVGLIGLVMLMI
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
YKKVFHCAGLEPVNMSESDDQLESDNELHTRNINLDNDDNEMSDEDMVKICDQIGAKKVKNEMLSKSFKGDANKQQTFKRENKNRPQEISSKIKVPKMRQVVVVPKSATATRDPRFDDLCGSEYNEELFNNRYQFLDNIKQREKLNLKKQVKKTKRGTKDQQQLKYLLSRMEQQEIAKKQRMEKREEERKWKKEEMKKVKQGIKRPYYLKNSTKNKMVAELRNKDGAASNKSEIRKEKRQKSRESKVMPYTRR
The following text describes a protein:
Function:
Able to catalyze the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids.
Sequence:
MALTCTDMSDAVAGSDAEGLTADAIVVGAGLAGLVAACELADRGLRVLILDQENRANVGGQAFWSFGGLFLVNSPEQRRLGIRDSHELALQDWLGTAAFDRPEDYWPEQWAHAYVDFAAGEKRSWLRARGLKIFPLVGWAERGGYDAQGHGNSVPRFHITWGTGPALVDIFVRQLRDRPTVRFAHRHQVDKLIVEGNAVTGVRGTVLEPSDEPRGAPSSRKSVGKFEFRASAVIVASGGIGGNHELVRKNWPRRMGRIPKQLLSGVPAHVDGRMIGIAQKAGAAVINPDRMWHYTEGITNYDPIWPRHGIRIIPGPSSLWLDAAGKRLPVPLFPGFDTLGTLEYITKSGHDYTWFVLNAKIIEKEFALSGQEQNPDLTGRRLGQLLRSRAHAGPPGPVQAFIDRGVDCVHANSLRELVAAMNELPDVVPLDYETVAAAVTARDREVVNKYSKDGQITAIRAARRYRGDRFGRVVAPHRLTDPKAGPLIAVKLHILTRKTLGGIETDLDARVLKADGTPLAGLYAAGEVAGFGGGGVHGYRALEGTFLGGCIFSGRAAGRGAAEDIR
The following text describes a protein:
Function:
Involved in formation and maintenance of cell shape.
Sequence:
MKFFKNKLTVTIIVLSVTFLVLITQSAERSKISFVESGIGTVVNPVQGVFYKVNKKIRNSIGFVLNIPDVKKENVELKSKNSKLESQLVEYKSLKDENERLRKMLNFKNQHSEFNYVGADIIGKSGGNYLDEFTINKGSNDGISKGMVAITNEGLVGQVIATGGSWAKVQSLSNENLAVSAMVDSTKENSGVIKGFKDSQNNILAKLYFLPMDSKIKEKDIILTSGLGAMYPKGIRIGEVKSIEVDKGKVMKNAIIKPYVDLRKIEEVFIVMPKNKEEVKY
The following text describes a protein:
Function:
Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MESRSSPRLECSGAISAHCSLHLPDSSDFQLIFVFLVEMGFHHVGQAGLELLISSDLPTSASQSAGITDMKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASISEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSSIEGLGAESGPIDST
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
Sequence:
MGRRILNDALRTTVNVERRGKATALLQPISGVMISFLNIMKHRGYIKNSRSSIHIELEKLLWNFREGLKIVKLLLIGRTSDLRKSSKTEFRCFRHGRSSSFSAGRPNQEQFFPARRPNHFRTDGSGRRAALRRAITTRIRPAVRLRH
The following text describes a protein:
Function:
Acts as a ribosome collision sensor, splitting the ribosome into its 2 subunits. Detects stalled/collided 70S ribosomes which it binds and splits by an ATP-hydrolysis driven conformational change. Acts upstream of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation. Probably generates substrates for RQC; Endonuclease that is involved in the suppression of homologous recombination and thus may have a key role in the control of bacterial genetic diversity.
Sequence:
MRDVLEVLEFPRVRALLAERAKTPLGRELALALAPLPREEAEKRHELTGEALSYPYALPEAGTLREAYGRALAGARLSGPELLKAAKALEEAMALKEELLPLKNALSQVAEGIGDHTPFLERVRKALDEEGAVKDEASPRLAQIRRELRPLRQQILDRLYALMDRHREAFQDRFVTLRRERYCVPVRAGMAQKVPGILLDESESGATLFIEPFSVVKLNNRLQALRLKEEEEVNRILRDLSERLAKDEGVPKTLEALGLLDLVQAQAALARDLGLSRPAFGERYELYRAFHPLIPDAVRNSFALDEKNRILLISGPNMGGKTALLKTLGLAVLMAQSGLFVAAEKALLAWPDRVYADIGDEQSLQENLSTFAGHLRRLREMLEEATSHSLVLIDELGSGTDPEEGAALSQAILEALLERGVKGMVTTHLSPLKAFAQGREGIQNASMRFDLEALRPTYELVLGVPGRSYALAIARRLALPEEVLKRAEALLPEGGRLEALLERLEAERLALEAERERLRRELSQVERLRKALAEREARFEEERAERLKALEEEVRAELLKVEAELKALKEKARTEGKRDALRELMALRERYAKKAPPPPPPPGLAPGVLVEVPSLGKRGRVVELRGEEVLVQVGPLKMSLKPQEVKPLPEAEPGKPLLAKPRREVKEVDLRGLTVAEALLEVDQALEEARALGLSTLRLLHGKGTGALRQAIREALRRDKRVESFADAPPGEGGHGVTVVALRP
The following text describes a protein:
Function:
May contribute to coordination of muscle contraction as regulatory subunit of a nonessential potassium channel complex. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord.
Miscellaneous:
MISCELLANEOUS: Gain of function phenotype is phenocopied by exposure to the unc-49 agonist muscimol.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Associated with dense bodies.
Sequence:
MKFQKMGDSNTWDLVGEQQQRKKSRSPSRASRVDSELLVGVENAAELEALGLGKEQLEEEARRHKKQRSKSPALENIRKTSIHLLQKFGAIPKKKDDSVLLFRFHDIPDIPLESLCIRPKEFFEEPKVFSFRDMGREQQKAEVNEKCSYLFRGTSFDHDDHFELPTETGRVPEYDHFCPIHGSRRRLPRNKLVTMQTLMHSVDDEDNEDLAYIYGHDFLAKLVRKKKREMMSGTEKERANKIKRKIMSNLWILSVAFLFLFTAFNGLQNLQTSVNGDLGSDSLVALYLSLAISSLFVPSFMINRLGCKLTFLIAIFVYFLYIVINLRPTYSSMIPASIFCGIAASCIWGAKCAYITEMGIRYASLNFESQTTVIVRFFGYFFMIVHCGQVVGNMVSSYIFTLSYSQALRGPEDSIYDSCGYQFPKNLSDLTELAESNLARPPQKVYVAVCLAYLACVIISGMIMSMFLNALAKDARNRKMAQKFNSEIFYLMLKHLINIKFMLLVPLTIFNGLEQAFLVGVYTKAFVGCGLGIWQIGFVMACFGISDAVCSLVFGPLIKLFGRMPLFVFGAVVNLLMIVTLMVWPLNAADTQIFYVVAAMWGMADGVWNTQINGFWVALVGRQSLQFAFTKYRFWESLGIAIGFALIRHVTVEIYLLITFFMLLLGMCGFLAIENFDHIIKFWHHLIHTSCPEKEPLDDRNSDFE
The following text describes a protein:
Function:
Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis (By similarity).
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction (By similarity).
Sequence:
MVAGEVPESTQCPSLTSLNTKDVVRRRHKRRSRQHQRFMARKALLQEQELLSTAPGPGLCLLPSPSQMPAVTEASDSRRQRPKARSGSNGLCSKKSVPREAPRPGPIKCVAIDCEMVGTGPQGRVSELARCSVVSYSGDVLYDKYIRPEMPIVDYRTRWSGITRQHMHKAIPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPRSQTRDTTYVPNLLSQPSSLIRTRVSLKDLALNLLHKKIQVGHQGHSSVEDAMTAMELYQLVEVQWEQQVASSAQAPAEDRGPDSSTDVEQYMDDQYWPEDLTQSTGAETNGGPDRQEGEEGQGARSAPP
The following text describes a protein:
Function:
Photolyase involved in the repair of UV-induced (6-4) lesions in DNA. Catalyzes the photoreactivation of (6-4) pyrimidine-pyrimidone photoproducts by using blue-light energy. Can repair (6-4) photoproducts in ssDNA as well as in dsDNA.
Sequence:
MSQLVLILGDQLSPSIAALDGVDKKQDTIVLCEVMAEASYVGHHKKKIAFIFSAMRHFAEELRGEGYRVRYTRIDDADNAGSFTGEVKRAIDDLTPSRICVTEPGEWRVRSEMDGFAGAFGIQVDIRSDRRFLSSHGEFRNWAAGRKSLTMEYFYREMRRKTGLLMNGEQPVGGRWNFDAENRQPARPDLLRPKHPVFAPDKITKEVIDTVERLFPDNFGKLENFGFAVTRTDAERALSAFIDDFLCNFGATQDAMLQDDPNLNHSLLSFYINCGLLDALDVCKAAERAYHEGGAPLNAVEGFIRQIIGWREYMRGIYWLAGPDYVDSNFFENDRSLPVFYWTGKTHMNCMAKVITETIENAYAHHIQRLMITGNFALLAGIDPKAVHRWYLEVYADAYEWVELPNVIGMSQFADGGFLGTKPYAASGNYINRMSDYCDTCRYDPKERLGDNACPFNALYWDFLARNREKLKSNHRLAQPYATWARMSEDVRHDLRAKAAAFLRKLD
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTDHNLLRLIVTIGEFFAMTPSRPKTRAKIYALCVVTALVTPSALSIIYYRQPIYAKISETKSIVAMVMGTIVNAFSCYTVLAPVLCKRQQYCQLMSKLLGNHQLVYNCHTFGRFLAPNLTYLLVALYSGYVWTDILGFGYFREYLAEAVQLYFQFYYTYFLCVIVCIFRGKYRNINLLLTEQLQNRRFFAKKMEGLVCSIKELNMIFNEFFGWPIIMIILYSSLMVLNYIDEVFNNNFGYDKKQYIGVVVANVGVAFMINVGTVTLILSCDAVLEEVKTTLLLAYKIRQVFPNEKKNISEFINVVLNNYPDFSAAGFFSINKTTLLQIIGNVTTFFIIIIQFNNKH