lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MDRKRINGPEKSIVPQPLISTALGHPHTGQRADKRRPDQIRPIYTKAGTIPQANGSAYIETGNLKVICAVYGPRQSSSRQLSSSTGTLQCDFKFAPFSGEKRKGYAKDDQEKEFSMVLEQALTPSIRLENYPKFTIQVFVIVLENDGSMSALAAAISCASLALANAGIEMLDMVAASSIAYFGESMLCLDVSLKEEMVQDGAMLVSYMPSLNEVTHLIQTGLATTSQCTKAIELGVDACSQIHTILQEALLSE
The following text describes a protein:
Function:
Plays an important role in the removal of damaged mitochondria via mitophagy by controlling the stability and localization of RAB7A. Required for the recruitment of RAB7A and ATG9A vesicles to damaged mitochondria and promotes the stability of RAB7A by inhibiting its proteasomal degradation during mitophagy.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAAAVSSVVRRVEELGDLAQAHIQQLSEAAGEDDHFLIRASAALEKLKLLCGEEKECSNPSNLLELYTQAILDMTYFEENKLVDEDFPEDSSSQKVKELISFLSEPEILVKENNMHPKHCNLLGDELLECLSWRRGALLYMYCHSLTKRREWLLRKSSLLKKYLLDGISYLLQMLNYRCPIQLNEGVSFQDLDTAKLLSAGIFSDIHLLAMMYSGEMCYWGSKYCADQQPENHEVDTSVSGAGCTTYKEPLDFREVGEKILKKYVSVCEGPLKEQEWNTTNAKQILNFFHHRCN
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the abscisic acid (ABA) and ethylene signaling pathways. Regulates acropetal transport of auxin (IAA) in roots and hypocotyls, and thus modulates root architecture (e.g. lateral root formation). The heterotrimeric G-protein controls defense responses to necrotrophic and vascular fungi probably by modulating cell wall-related genes expression; involved in resistance to fungal pathogens such as Alternaria brassicicola, Plectosphaerella cucumerina and Fusarium oxysporum.
Subcellular Localization:
Cell membrane. Golgi apparatus membrane. Golgi apparatus, trans-Golgi network membrane. Cytoplasm. Note=Localized to the cell membrane when attached to beta subunit GB1 (Probable). Present in the cytoplasm when associated with NUDT7.
Sequence:
MREETVVYEQEESVSHGGGKHRILAELARVEQEVAFLEKELKEVENTDIVSTVCEELLSVIEKGPDPLLPLTNGPLNLGWDRWFEGPNGGEGCRCLIL
The following text describes a protein:
Function:
Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins.
Sequence:
MGNSHSSENGGNSGSGGGSGGGGSGYSGVSENMIIDLEGRYHIDYKNRNYKKLKPQMFSTFFEHYEIVQADSLINSDFIKNKTVKKNRDNSSNNNSNNNSNNNNNNNTLNNSTIITTTTTTTTTSTPTTTIMITPPQQQQQQRTSLDLTNRDISESSTPNEQQIRLAQEETENQEIVESSFLKSSPVPSPSSSVLKSFESDFQLNTDLTTETFDDNSAEKKRQQQQQQQQNEDSKQSSQQQTQKSKDKDESAKIVNNKSSSTTNIKPILAAAQTSRSTSIPAFNRNKTKEPTKQKIKKEHSTLRKNSLSSSNIITPNNTTNTNAKDGASYFNENSLMSVKSDIKIFSLDLSINRLENITNDILSIMARFEIQELTLSTNFFQIIPDLQLVKSLTTVNLTRNKLSKLQTSVFIELPSLTSLILDRNFISSIPDDIDQIKNLKYLSIKHNALEYLPNSLSNLSQLISLDLSQNKLKTLPPNFDDLINLRMVWLSYNQITSLPSMRKLVNLVTFDISSNKLLSLPKDFAYLVPSRIKQSYSDIDIDEYDENINTCNNINSNNNDSNNSNNNNNNNNDNNNNCNKNNILEMINSTELEGGGLGCLKELNIRDNRELISLPVEYKQVESLMTLVTSIPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDDARDAPQYDISQHFEQTNCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFCTNILNISSHNSNNKNNNSSNNRKSINNRKSNNIIITINNSSNSNNNNSTDNSNNSSTSTTPNLSSLSSDSSSSASLSKLSISK
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSQICDFYDNQNVLITGGTGFLGKVLIERLLRATNIAQIFLLIRPKRGKDAETRLFDMLDNVYFNKVRAENPNFKTRISVVEGDCVSDKLGLSLQDSEKLVAKVNIVFHVAATVQFNGNIKSAYQINVEGTKNLLKLCQKMKNLKSVVHVSTAFSNCHLDTIDEVFYNYDLGYDQVRVMLQDLTPKQADELSQKILDGWPNTYAFTKALAEAMIASEAKDLPIGVFRPAIVTSTYKDPIENWNDSYGGPNSILVAAGMGYLRLCPCDPRSYMEAVPADLTIASLIAVAWDIYNKNKTEIPVYNYVSSIDNPITYYEFFHFNAMYFPFYPLTKAQWAPKSRTMKKTLPYHVLRLLYHYVPALILDFFRVVRFQKPEMLSRIRKLHTLLGLLSFYNEKKWKFSNKNVKLLWEKMNEGDRELYNFDISTVQWIHYFRNYYKGLRVYLLKDDLSTLPQARKKMKRFEFLHNLALFGIYFLVMNLIWITFSKMYSSF
The following text describes a protein:
Function:
Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.
Subcellular Localization:
Cell envelope.
Sequence:
MTNYEQVNDSTQFSRRTFLKMLGIGGAGVAIGASGVGSMWSFKSMFNTPEDPEKDAYEFYGKVQPGITTPTQKTCNFVALDLKSKDRDAIKAMFKKWTVMADRMMDGDTVGKPSNNPLMPPVDTGESIGLGASKLTITFGISKSLMKKIGLSSKIPDAFKDLPHFPNDQLIDDYSDGDIMIQACSNDSQVSFHAVHNLVRPFRDIVKVRWAQSGFISAKGKETPRNLMAFKDGTINPRKNNQLKDYVFIDDGWAKHGTYCVVRRIQIHIETWDRTALEEQEATFGRKRHSGAPLTGGKEFDEIDLKAKDSHGEYIIDKDAHTRLAKEANTSILRRAFNYVDGTDDRTGNFETGLLFIAFQKATKQFIDIQNNLGSNDKLNEYITHRGSASFLVLPGVSKGGYLGETLFD
The following text describes a protein:
Function:
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
Subcellular Localization:
[Phosphatidylserine decarboxylase 1 alpha chain]: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain; [Phosphatidylserine decarboxylase 1 beta chain]: Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Sequence:
MKLTRIFFIPTDRLKVRLKNTKTNWKPIPIWIGASLLGLITYLKKIGDRSGSEGEGSTRKADSTTITPVKIEGPWQVHVLGALPLRTISRLYGLLNSYTLPIWFRVPGYKLYSWIFGVNLEEAEIEDLKQYKSLNDFFMRKLKKECRPIDPHAILTSPSDGKIINFGTIEGRRVGSVKGLSASIFHTLHFFCFQKKLNESEGKKRSSEESQVSNSRFANINDISYSVDELMGGSENTQHDQDPTESSVASQPVSPGAGLASSVKVHTDIVRGELETLPSSGNRMFFFVVYLAPGDYHRFHSPADWKVERRRHFAGELFSVSPWMAGKLADLFVLNERVALLGRWRHGFFSMTPVGATNVGSILINFDRELRTNRVDKRCHEEMVYGTNNAIFDGQVLAKGTEVGAFSLGSTIVLVFEAPEQFQFSVKKGEPVRVGQAIGNI
The following text describes a protein:
Function:
Necessary for the secretion of IPA invasins.
Subcellular Localization:
Secreted. Host cell. Note=Secreted via Mxi-Spa type III secretion system (T3SS), and delivered into the host cytoplasm.
Sequence:
MLDVKNTGVFSSAFIDRLNAMTNSDDGDETADAELDSGLANSKYIDSSDEMASALSSFINRRDLEKLKGTNSDSQERILDGEEDEINHKIFDLKRTLKDNLPLDRDFIDRLKRYFKDPSDQVLALRELLNEKDLTAEQVELLTKIINEIISGSEKSVNAGINSAIQAKLFGNKMKLEPQLLRACYRGFIMGNISTTDQYIEWLGNFGFNHRHTIVNFVEQSLIVDMDSEKPSCNAYEFGFVLSKLIAIKMIRTSDVIFMKKLESSSLLKDGSLSAEQLLLTLLYIFQYPSESEQILTSVIEVSRASHEDSVVYQTYLSSVNESPHDIFKSESEREIAINILRELVTSAYKKELSR
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MGNTTTKFRKALINGDENLACQIYENNPQLKESLDPNTSYGEPYQHNTPLHYAARHGMNKILGTFLGRDGNPNKRNVHNETSMHLLCMGPQIMISEGALHPRLARPTEDDFRRADCLQMILKWKGAKLDQGEYERAAIDAVDNKKNTPLHYAAASGMKACVELLVKHGGDLFAENENKDTPCDCAEKQHHKDLALNLESQMVFSRDPEAEEIEAEYAALDKREPYEGLRPQDLRRLKDMLIVETADMLQAPLFTAEALLRAHDWDREKLLEAWMSNPENCCQRSGVQMPTPPPSGYNAWDTLPSPRTPRTTRSSVTSPDEISLSPGDLDTSLCDICMCSISVFEDPVDMPCGHDFCRGCWESFLNLKIQEGEAHNIFCPAYDCFQLVPVDIIESVVSKEMDKRYLQFDIKAFVENNPAIKWCPTPGCDRAVRLTKQGSNTSGSDTLSFPLLRAPAVDCGKGHLFCWECLGEAHEPCDCQTWKNWLQKITEMKPEELVGVSEAYEDAANCLWLLTNSKPCANCKSPIQKNEGCNHMQCAKCKYDFCWICLEEWKKHSSSTGGYYRCTRYEVIQHVEEQSKEMTVEAEKKHKRFQELDRFMHYYTRFKNHEHSYQLEQRLLKTAKEKMEQLSRALKETEGGCPDTTFIEDAVHVLLKTRRILKCSYPYGFFLEPKSTKKEIFELMQTDLEMVTEDLAQKVNRPYLRTPRHKIIKAACLVQQKRQEFLASVARGVAPADSPEAPRRSFAGGTWDWEYLGFASPEYRRRHRQRRRGDVHSLLSNPPDPDEPSESTLDIPEGGSSSRRPGTSVVSSASMSVLHSSSLRDYTPASRSENQDSLQALSSLDEDDPNILLAIQLSLQESGLALDEETRDFLSNEASLGAIGTSLPSRLDSVPRNTDSPRAALSSSELLELGDSLMRLGAESDPFSTDTLSSHPLSEARSDFCPSSSDPDSAGQDTNINDNLLGNIMAWFHDMNPQSIALIPPATTEISADSQLPCIKDGSEGVKDVELVLPEDSMFEDASVSEGRGTQIEENPLEENILAGEAASQAGDSGNEAANRGDGSDVSSQTPQTSSDWLEQVHLV
The following text describes a protein:
Function:
May play a role in signal transduction pathways that involve calcium as a second messenger.
Subcellular Localization:
Membrane; Lipid-anchor.
Domain:
There are 3 contiguous domains conserved in the CDPK subfamily: a kinase domain, an autoinhibitory (junction) domain and a calmodulin-like domain. The autoinhibitory domain (325-355) inactivates kinase activity under calcium-free conditions.
Sequence:
MGACFSSHTATAAADGGSGKRQQRKGDHKGKLPDGGGGEKEKEAARVEFGYERDFEGRYQVGRLLGHGQFGYTFAATDRASGDRVAVKRIDKAKMVRPVAVEDVKREVKILKELKGHENIVHFYNAFEDDSYVYIVMELCEGGELLDRILAKKNSRYSEKDAAVVVRQMLKVAAECHLHGLVHRDMKPENFLFKSTKEDSPLKATDFGLSDFIKPGKKFHDIVGSAYYVAPEVLKRRSGPESDVWSIGVITYILLCGRRPFWNKTEDGIFREVLRNKPDFRKKPWPGISSGAKDFVKKLLVKNPRARLTAAQALSHPWVREGGEASEIPVDISVLSNMRQFVKYSRFKQFALRALASTLKEEELADLKDQFDAIDVDKSGSISIEEMRHALAKDLPWRLKGPRVLEIIQAIDSNTDGLVDFEEFVAATLHIHQMAELDSERWGLRCQAAFSKFDLDGDGYITPDELRMVQHTGLKGSIEPLLEEADIDKDGRISLSEFRKLLRTASMSNLPSPRGPPNPQPL
The following text describes a protein:
Function:
Putative transcription factor that seems to be involved in the sporulation process. Suppresses the lethal phenotype of RPM2 deletion.
Subcellular Localization:
Nucleus.
Sequence:
MVKDNRDSDQDQDFSSAHMKRQPEQQQLQQHQFPSKKQRISHHDDSHQINHRPVTSCTHCRQHKIKCDASQNFPHPCSRCEKIGLHCEINPQFRPKKGSQLQLLRQDVDEIKSKLDTLLANDSVFVHLLQQIPMGNSLLNKLNLHPTPTPGTIIPNPDSSPSSGSPTSSAAQRDSKVSVQTYLSREPQLLQANQGSNTNKFKANNEASSHMTLRASSLAQDSKGLVATEPNKLPPLLNDSALPNNSKESLPPALQMAFYKNNSAGNTPNGPFSPIQKTYSPHTTSTTVTTTTNQPPFAATSHVATNNNADRTKTPVVATTTTMPLLPSPHANVDEFVLGDISISIEKANRLHHIFVTRYLPYFPIMYSNNATELYSQSQLLFWTVMLTACLSDPEPTMYCKLSSLIKQLAIETCWIRTPRSTHISQALLILCIWPLPNQKVLDDCSYRFVGLAKSLSYQLGLHRGEFISEFTRTQTSMPNAEKWRTRTWLGIFFAELCWASILGLPPTSQTDYLLEKALSCGDEESEEDNNDSIDNNNNDKRNKKDEPHVESKYKLPGSFRRLLSLANFQAKLSHIIGSSTSSPDGLLEPKYRAETLSILGKELDLLAKTLNFQSDDTVNIYFLYVKLTVCCFAFLPETPPTDQIPYVTEAYLTATKIVTLLNNLLETHQLIELPIYIRQAATFSALILFKLQLTPLLPDKYFDSARQSVVTIHRLYRNQLTAWATSVENDISRTASMLEKLNFVLIMHPEVFVEEDGIISRMRSHLTGSLFYDLVWCVHEARRREMDPEYNKQALEKAAKKRKFSSNGIYNGTSSTGGITDRKLYPLPLYNHISRDDFETVTKTTPSGTTVTTLVPTKNALKQAEKLAKTNNGDSDGSIMEINGIPLSMLGETGSVKFQSLFANTSNSNDYNNNRTLLDASNDISIPSNSIYPVASVPASNNNPQSTKVDYYSNGPSVIPDLSMKRSVSTPVNHFPASVPGLRNHPVGNLSNNVTLGIDHPIPREHSNLQNVTMNYNNQFSNANAIGRSQSSMSHSRTPIASKSNNMTDLHSVVSDPGSSKSTAYPPLSLFSKSNDINSNKTNQRFSTGTNTVTSSNFQTIDNENNVKTPGNKLTDFFQQQSAGWIEGNSSNDDFFGWFDMNMEQGF
The following text describes a protein:
Function:
Removes the phosphate from trehalose 6-phosphate to produce free trehalose.
Sequence:
MWRSYSAAPQGSSPGTSLASLGPGSGVWGPSRASFEQFGDEDSNDGKGRHGGHGGHRAGHSRSPLGGDQSEKDEAYLKWQEKHPCVLAHFASFKAAVDGKRLAVFLDYDGTLTPIVSNPDEAVMSEEMRDVVRSVARAFPTAIISGRGREKVEAFVQLKELFYAGSHGMDIAGPRGGTNGCQVSGNEFVTAFQPAAHFRPLIDHIYTQLQERLKEVPGSSVEHNNFCVSAHFRNCPGEAWQDVISAVEELVAQHDDLRMTRGRKVVEVRPKVDWHKGTALSHLVDALGLAQEPDVVAIYVGDDHTDEDAFRTLEETRRGFGILVSTRAKPTRARYTVRDPACVKDFLSGIVEWSKSDSNGWRAKPCCNGWSMDGLAATGAGPEAPQQQ
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MELPKQLGTFSVTSDGFFNDDRNLRSYKPVADRGRLDLDKGYDAKFVDYKDEEDDGDLDNILKWIKSQDPNVLAGVEFVTRRAILTKVMRGQWWKLAVTKFNGIWYISTTAVHEQKTGKQPSAEKQKGDKRKLYWGHKFEQYMTGCADSPEGEPNTVDLNEGFYTVVKYKLKSHSLLFSAEVDAIGETGSYVEFKTFAIPQKKDVDQEVNTKFKNCWVQSYLAGVDEIVFGIRRDDKAKGVVTESQTRKITDGKAEYDSDWKSYADRCDKFLSEVKDYVKEDNASIVYLYQHGQKPYKEPKARPFLTVLTADDEQ
The following text describes a protein:
Function:
Repressor of the asc operon. The cryptic operon is activated by the insertion of IS186 into the ascG gene.
Sequence:
MTTMLEVAKRAGVSKATVSRVLSGNGYVSQETKDRVFQAVEESGYRPNLLARNLSAKSTQTLGLVVTNTLYHGIYFSELLFHAARMAEEKGRQLLLADGKHSAEEERQAIQYLLDLRCDAIMIYPRFLSVDEIDDIIDAHSQPIMVLNRRLRKNSSHSVWCDHKQTSFNAVAELINAGHQEIAFLTGSMDSPTSIERLAGYKDALAQHGIALNEKLIANGKWTPASGAEGVEMLLERGAKFSALVASNDDMAIGAMKALHERGVAVPEQVSVIGFDDIAIAPYTVPALSSVKIPVTEMIQEIIGRLIFMLDGGDFSPPKTFSGKLIRRDSLIAPSR
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MDPVYEIDWQADVNQITLGHGDIVECAWSASNFFAFTTEKNNQGSVTQYLHILNPNQPWGVFSTKYNDGAITCLQWDHTGTRLVSGDNHGLCCLWTMSNSLCNVWTHQNKHNIFLEGEEILSLGWLHNGARFLFHIDKMESSNLGEKFDRAKFWPTVMQHGGKAMEGFIVVTGSGLAAVRLLLVDGESVESQFRLNVMCHQQIADIAFTSQGKVVVMTTDSEIQHFIQFHEIQLTYNTQDHLISHEVSALPSLQLRCASEEHSPYTYISHAHFVSRENQDHVLICVSGPTGSKFESWLIRKESVQLHRIFQQNTNPVSTTPDVSKCWHYVTNSTHLPQVLNFSIPTLPIDASSSENKVSQESKFFCGFCFAVALADNTIQILHRLFLQVLVTQHLPVTTNSQETTPGKAMKMTQQFGVRHVSFSTLSCAMVCFIAADKHGRLLLYRIPPWLTTPNRTNTMQSLKQLLQLMLYCLVSGKEWWEILLHVHPNLVEPLVKQLSVECGNQTSAVQQVLELRLQALKISIYHITASPVATDLHLKMLFQAISLVFRSLVRPHQQVGGEEIDPATKLQNISRTSTETNIDQLVQNVDTDPQTLQSMQQLIQWVADVALYLLASVPLYKQANRPGYSLYWDRDWLSLLREMLVLIRVWGLLKSACSPVFNVLDSRMDVLSHVFKLVTQLWMASTDDHRMTDLPTSLINECSALPFHIIIPPLEPTPPPNSVLSQMRNFSGTRRFTFGETPQDSYIMLSRQHMMDHVAVAGSSGKVDSLRRIFLGKSPNQELKECVRCGVTTTCNNLLRSTLKVWDQRFVSSCVCGGHWKKLNSHPVPLH
The following text describes a protein:
Function:
Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3.
Sequence:
MAEENTQLCANCKRDIPAGNFTMHEMHCRRNIALCEHCQEPVPRSELEEHRQQEHTKVQCKCGLKVEKGQMETHQKLACSLRLTGCRYCELEVAFSRLAEHEGYCGARTEPCPQCHRNVMVRELAAHPAVCGPQPPEERNNNRAGPGPARRQPEAWFETNAVRNVLSGHGLPDSSSPLGLGIPRTLEARVQNSTRAALRRNMALRNRDQNQTAKVENLARNTGWQGAETPGDESSELDYMLALSLQSDHSHDTWVDSWVHSWEGNGNRTAEATEVLTDSLSTLIQPFISEPIVGPDNNTLDRRTDSMLPCEFCEELFPEEDLILHQTGCSPASALASFSKQGGSQQEGPKPLDGAPSNSTSLWPRLDSVFIPCEFCGVTLEEDVVFHHQDKCDLRPRAACSVERPSLQKALPTKEDNLDRCSSELLRRRFGPQADPVSETQKWVAEAAVGRGVQDVAPLSSRGHWRPGLKSSLPPAGRAVHCAGQVRRAGGRADSRPPEEHASLTALPGGRLDGRTNTRNTATPKTLAPETRSVEKGEE
The following text describes a protein:
Function:
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MNTVLSRANSLFAFSLSVMAALTFGCFITTAFKDRSVPVRLHVSRIMLKNVEDFTGPRERSDLGFITFDITADILFRKYFIDFSLQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKDMKTKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLVTGSGHVSVPFPDTYEITKSY
The following text describes a protein:
Function:
Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase. Capable of transferring glucosyl residues to unbound acceptors such as free oligoglucans or oligoglucan derivatives.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFAYATLLIGESYLPGVLTLGNRLKQLGTKHKLLILLDVSSISLQSKQLIESIYDELIPIDNQLILSPLQKLSEQLQRQELSISYSKILLWNQLDYDSIVYLDADVLPLQNLDRLFIDYDVDDNQIGAASDSGWPDIFNSGVFKLKPNKQTFEQLLEFSVDPNNTFDGGDQGLFNEYFKLENWIRLPYLYNVTPNYRQDYQYLPAFNRFFKDIKVLHFIGQVKPWHYENVLASDLANFHQYWWDEFNKLIGDDVALKYTLLNLPRGEATKLKFGKTVNAWDKKDIEQDTELVEEEEEEEEVVSHSPIFPWEHRQEKRQPTRVFQNIPTTSTVGNVSGKSGTKEEQELDRSTETLKRTHIS
The following text describes a protein:
Function:
Plays a role during spermatogenesis.
Subcellular Localization:
Cytoplasm. Note=Localized to the peri-acrosomal region of the round spermatids as well as the heads and tails of the elongated spermatids and spermatozoa. Redistributed within the head during sperm capacitation.
Sequence:
MNSSPPFLLKISAPSTSPQADCPNNYSFPPESPSSCRKGFTPVLTLEVPVAPGKDFNDHLSCNAGLSPNAGNRFTNPPYSREPFSCLTISSPCLPRRIPTPPPPPPVLSSPPPPERCPFEPFSPLLGRLYRQEPAGSSSPCFDRFSLQGSPSPHQRNLCCNYIDSPESQRSCPPSPRLCYVTSPPLIHQAPRASPVTSPELTHITLETGPVISTPLMPGSQGNYSIISPLLTHRPLRPGLAISPPLAHRSVETRPLTPASISHRGPHCPSRRSYNDPPLSSASSPPSGNPYHDNPMPPNSCEPKPQLDVPLGKNGCGPPLSSQAGMSGSPISPQEGCIHYSHLCPDSQISAPRSPFCVINLPPESAGSPSSSLPQALQKPCVGSFLWEPGGNSYLLLTPGTIISGPSCTTGPPLPQCPNPSPYFPSPLNNQCVAPPQSPRGYNEPRPPTSAPPQMKSPKSPESRRNPYKCRSLDNTPHHTPPSHSKSHKTNTCPQPPSQSFGLFSPCMEPAITTTSNSCPKEPPPETAVLKTVAPTSCPHSSPCNPALPSRYPKSSPHVPPPVSPCNTHMYSVVPPTSHLSPLSSPLNQSIPLPQPAVLPCGTYSAPRGPPSHIKSVAPPCSTHIYSFIPLRTPFDPRCLPVVPRARFCPTTVPCGIHTYAVTSPVPLNNPSQIPYSCSLPPSKTSSTCSTSVSSTIVCSDYQSSDSQINHQNKSQSPNKNSSLHNQSKSPLRRGAFQSRSRSRSSSPLQSSTQDRNESTNMGVKHHKRSRKQSQSPADGKIESQSKSLQHRKSVGQIKSPHSKKK
The following text describes a protein:
Function:
Has a role in meiotic nuclear divsion where it promotes the movement of 'horsetails'.
Subcellular Localization:
Cytoplasm.
Sequence:
MDKNIKREIEIKRAKLLLLKNKENCTDAVSSSNKEGPKQISEDQLSNFLCKILKPTNLTPQTYSLESKSSNLVSDCELKISSVYQSYSSTFNVSNHVPSISKTVNIRETSKHLKHSTKAPKCSLPTSALEIDHLNNFLHSSAKILDRALCDQSNQLFTDYTVKKKSKKNKSQLEENGLNHLFTFQDEKITLNSVVNSISYSSFFEELLITSYAKPKEALRTRGLAIVWNQRWKNSPESVLKARSEITVCKPSPFHPQLIAGGAYNGQVFLWDLRQGQYPVSFTTIISGGHLEPVTDITYINNPPSNNIVTCSTDGLVHIWEPDMFSRPSETICLSSQVDSSSQCIPATCLSFIPENNMEFLVGAEDGKLQRGYRSDYSETKAVQPSNVSYEGHNVFISGIDVMTSNSQNVFLEKNKDFALTSSFDWTVRLWQCSPSRNQHELVPSNDLDEQVIINSCKTFTHKAMVFDVKWCVSEPCCFASVDALGNLNLWDLQKDVEAPVTSDIPDGKPLNKIAWQPEKRNLACGGLNGNVHIYKHLSPNLAN
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MFGRINISSAKRAKPRGKRKEAPKSIFDSEFPEPKFLDKGILATDGCTYYKKALIEGQEFNLFDSAQILTSDTTGSKDHLYYALILQMRSDTEGNKQAKVNWYWRKDELPEELKCFVLRRELLLSEAVEYIPLDAIRSKITVYSNVSNIGRKINHLITANTSEFLCNRGFFTCQAEFVAVSTIRRLMNLTLEDIEHVESGSKYDIARARLQLNYVKAVLGRQGEMQSIKAAIERFLMRGGCGGCLYISGVPGTGKTLCVKEVMKQIGNEVISGKIKDFEFYEINCLRFGESNNVFKEIWYQLTGEKLSVKSSIANLNALFTKSPPEKYMILLIDEIDILLTRKQTEIYCLMEWACLPKSHLIVICIANIMDLEQRLAPKVQSRFGKETIRFYPYKSDELKIIVEGRIKDLGIFHPTAIDYLCKNIANVGGDARKALEACRRSLDFVTEENSENSKKKTKSEEQIKLKTMVRAVKDMQEIRGMSILEKITLNEKLILISFLKEMKLKDLTSASMRDVVKRFYTIQKQFPDSPQVNTTMLMVLVGKLIDIKVLKTQDERVPSANSRLLLVCSEGDLLISLNKDKALKALVEPLMP
The following text describes a protein:
Function:
Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MIYMQVLISLHFRSSTATEPHPFSHPTTLSIVSTMSQATPPPFFTWVSSNLAAHGMPSSPDQMRYLADNGIRYLISLTTECRPPVEATPNVTWVPIGIDDYHPPTLEQVVEFMRVMEEAEEKNEAVSVHCLRGRGRTGTMVACYFIKMQKMSAAEAIAEVRHQRPGSVETVEQENLIRDYETFINKPSI
The following text describes a protein:
Function:
Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.
Sequence:
MDPETCPCPSGGSCTCADSCKCEGCKCTSCKKSCCSCCPAECEKCAKDCVCKGGEAAEAEAEKCSCCQ
The following text describes a protein:
Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Sequence:
FLVSHSYLTWPFRTFKKLGIPGPKPVLNFGNFLSYKKGSHVFDMDCYKKYGKVYGIYEGRQPILMIGDLGLIKEITVKQFHKFNNRQDLGSILKPFAGSLFVLKDTDWKRVRGAISPTLSSSKLKQVLFIIRLMFVIFSAYAMDVISSTAFGVDIDALNNPDHPFVTHAKAIFDMNLLKMYLYIMVPPPFNYLFTLWGFTFFPKFATDFFKHTVERVMKMRQDSADNTERVDFLQLMLKAHNKHRDETANGATLGPGLSKQEIVGNSMIFWLVGYDTTANTIALTAYNLALSQEAQDRAAGEIHRVVQNRGKLDYEAVHELHYLEMCVNETLRIYPGAKRFDRVCREDADINGLHIPAGMNINFPVWVIHHDPELWPEPDKFKPERFSKEEIATRDPYAFLTFGVGPRACVGMRLAMLEIKLALAKVLEKFRFVTCEKTEIPLRLANNNGNKVEGGVWLKVEARGQAPSSV
The following text describes a protein:
Function:
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Localization:
Nucleus.
Domain:
The F-box is necessary for the interaction with ASK proteins.
Sequence:
MKKRGRKSKKPEEKRAEYDPSSILPLELKIEILMKSPPKSIAKLGFVSNHWSSIIRGQVFTDLYMRRSLAHPRLLFSVYRPNMQMQFFHSCSQEDPSSDHRSVSYTLNSDLRYSFSPPIGGLIFGQNNTKAMIGNPSTGQFVPLPRIKTQRKHIFSIFGYDPVNDLYKVLCMTVRTLRGPHYFRWEDPMWEEPMTEEHQVFTLGPKQKWRMLECKYLHRHHSGSQGICRDGVMYYLASFNDKRSLMSFDLSSEEFNVTKLPEDYILQQFGNMVDHSGKIAIVSQAYSGPMDLWVLEDVSKEEWSKVAAIVPSITDIVGNDQRVIFRGILSTGEIILSLLPTPKPPFFFLCYDPKEKTARKVVIQGIGEDYAAINVFFDHVESHMVLSKLT
The following text describes a protein:
Function:
Involved in organization of the endomembrane system and is required for endoplasmic reticulum morphology and organelle distribution. May act by inhibiting the formation of PYK10 complex by binding to GLL23 and exporting it from the ER. Required for proper subcellular localization of myrosinase TGG2. Has no lipase or esterase activity.
Subcellular Localization:
Vacuole. Endoplasmic reticulum. Note=Also found in ER bodies. Retained in the ER when mutated.
Sequence:
MLLIPSFTANSNEPPPSKLSLSDLSMAILKSHFFLLFPLLLLHFHTVSFAQTLFVFGDGLYDAGNKQFLSQNRVDASFPPYGVTVGQATGRWSDGSIVPDYLAKFMGIPKISPILLTTADFSHGANFAIADATVLGSPPETMTLSQQVKKFSENKNKWTNQTRSEAIYLIYIGSDDYLSYAKSNPSPSDTQKQAFVDQVITTIKAEIKVVYGSGGRKFAFQNLAPLGCLPAVKQASGNVQECVKLPSEMAALHNKKLLQLLVELSRELNGFQYSFYDFFSSIQNRVIKSKTYTFETGNAACCGTGSINGSNCSAKNVCAKPEEYIFFDGKHLTQEANLQVGHLMWGADPEVIGPNNIRELMVLPLDITVILAGIQEAMAAMRPRQSNIESLYDIKKMESEMDNHWLYQVDKAISFMI
The following text describes a protein:
Function:
The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Functions as the major efflux pump for n-hexane and p-xylene efflux. Has been shown in one study to be involved in the active efflux of the autoinducer N-(3-oxododecanoyl) homoserine lactone, thereby playing an indirect role in quorum-sensing; but has been shown in another study not to be involved in efflux of this autoinducer. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine.
Miscellaneous:
MISCELLANEOUS: In both X-ray crystal structures approximately the last 100 residues are not ordered.
Subcellular Localization:
Cell inner membrane; Lipid-anchor. Note=The membrane anchor is not necessary for antibiotic efflux as the protein is functional when targeted to the periplasm by a foreign signal peptide.
Sequence:
MQRTPAMRVLVPALLVAISALSGCGKSEAPPPAQTPEVGIVTLEAQTVTLNTELPGRTNAFRIAEVRPQVNGIILKRLFKEGSDVKAGQQLYQIDPATYEADYQSAQANLASTQEQAQRYKLLVADQAVSKQQYADANAAYLQSKAAVEQARINLRYTKVLSPISGRIGRSAVTEGALVTNGQANAMATVQQLDPIYVDVTQPSTALLRLRRELASGQLERAGDNAAKVSLKLEDGSQYPLEGRLEFSEVSVDEGTGSVTIRAVFPNPNNELLPGMFVHAQLQEGVKQKAILAPQQGVTRDLKGQATALVVNAQNKVELRVIKADRVIGDKWLVTEGLNAGDKIITEGLQFVQPGVEVKTVPAKNVASAQKADAAPAKTDSKG
The following text describes a protein:
Function:
Secreted aspartic-type endopeptidase which is secreted and contributes to virulence.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MHLLQCLLSTISLASTVTAFVPYSFNLEVSTEGPPSNDVARRFVPWKLLLDDSYNNHGSSSNGVSLTLDLKKFPVRRDNKYKVVLADEPTTPNTAALNQEGLDYSYFATVRVGSQGQQMWLVLDTGGPNTWVFGSDCTTVACQRHETFGEAASKSLKLLPLNWAVGYGTGLVSGVLGTDSLSLAGLDVNMTFGLAKNASTDFESYPVDGILGLGRSANSNFNTPSFMETVATQRLLKSNIIGFSFSRNSDGARDGAANFGDLDTTRFTGDIVYTNTTGDSNNWRIPLDDASVNGTPCRFVNKTAVIDTGTSYAMLPPKDATVLHNLIPGAVTTSHGQNFTLPCNSTAVVQVSFSGLSYNISPKDYVGPAYGSACLSTIVGQALYGDDVWLLGDVFLKNVYSVFDYDNHRIGFANRSVPIASPTTTVAAAANPSATDGAGSTLTGSMAVHTGSASIVSRFVHWPFIFALLCMVLV
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
Sequence:
MFKGTFSLRDEKPGNCPFNNITSQAVWTVSSTQPGSGIQNLFDGNRDTYWQSDGNLPHQIIAQFAKKMFISVVKIAVSTQDDNYAPLQVDIQTGNDPNSMNSKGTFAIENFNGVNTFHIEIEAIFLAILIVRNLNDGKNSKIRSLQVFGSLRTISPEPSFAFKKPELAMHLGIR