lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (By similarity). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: Alters the p53/TP53 response.
Subcellular Localization:
Nucleus. Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane. Note=Localizes to the nucleus in most cell types. In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil-like cells (By similarity). Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility. Localizes to cytoplasmic vesicles which associate with actin filament and autophagosomal membranes upon starvation-induced autophagy (By similarity).
Domain:
The N-terminal region is involved in actin binding and actin nucleation activity.
Sequence:
MSFALEETLESDWVAVRPHVFDEREKHKFVFIVAWNEIEGKFAITCHNRTAQRQRSGSREQAGTPASDGSRGPGSPAARGRSEAAASATAALRSPGPRKSQAWAEGGSPRSARSLKGDPPRGPAGRGPESPLRSPARAKASPLRRSAESRDAIASATPVPPAPPVPPVSSVRVVSASGAVSEEIEVLEMVREDEAPQPLPDSEQPPSAAELESSAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPSGMWTVLFGGAPEMTEQEIDALCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYYESLSELRQKGYEEVLQRARRRIQELLDKHKTIESMVELLDLYQMEDEAYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQKKHALKEEMQSLQGGTEAIARLDQLESDYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASVHAQREELQKLQQKARQLEARRGRVSAKKAYLRNKKEICIAKHHEKFQQRFQSEDEYRAHHTIQIKRDKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRVAHSRRKSTASPVPCEEQCHSLPTVLQGQEKTEVGGGGSQLGPSQTAEPQSLVQLEDTSSEQLESTSLPPRAVVSSELPPPQSAPLLTSIDPKPCSVTIDPLPPPLPPTPPPPPPPPPPPPPPLPVAKDNGASTTAETLEKDALRTEGNERSIPKSASAPAAHLFDSSQLVSARKKLRKTVEGLQRRRVSSPMDEVLASLKRGSFHLKKVEQRTLPPFPDEDDSNNILAQIRKGVKLKKVQKEVLRESFTLLPDTDPLTRSIHEALRRIKEASPESEDEEEALPCTDWEN
The following text describes a protein:
Function:
Mediates the transport of urea driven by a concentration gradient across the cell membrane. Mediates the transport of urea across the cell membranes of erythrocytes and the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity). Facilitates water transport in erythrocytes (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Restricted to the basolateral membrane in various portions of the urothelium.
Sequence:
MEDIPTMVKVDRGESQILSCRGRRCGLKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSDKGDYFWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFCLATLLFLLLTTENPNIYRMPLSKVTYSEENRIFYLQNKKRVVDSPL
The following text describes a protein:
Function:
Probable oxidase that might be involved in lipid metabolism. Is not essential for the survival of M.tuberculosis in stress conditions.
Domain:
The C-terminal segment can alternate between an ordered and disordered state. Ordering of the C-terminal helix shields a large positively charged patch on the protein surface, potentially used for interaction with other cellular components.
Sequence:
MTRTRSGSLAAGGLNWASLPLKLFAGGNAKFWHPADIDFTRDRADWEKLSDDERDYATRLCTQFIAGEEAVTEDIQPFMSAMRAEGRLADEMYLTQFAFEEAKHTQVFRMWLDAVGISEDLHRYLDDLPAYRQIFYAELPECLNALSADPSPAAQVRASVTYNHIVEGMLALTGYYAWHKICVERAILPGMQELVRRIGDDERRHMAWGTFTCRRHVAADDANWTVFETRMNELIPLALRLIEEGFALYGDQPPFDLSKDDFLQYSTDKGMRRFGTISNARGRPVAEIDVDYSPAQLEDTFADEDRRTLAAASA
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MEAYSRDLLRGLGGGDEAGRGEEKPRRLDSQAEEVELSLGLSLGGRFGQERRRGEGLARSSSVACIQQAALAPPALGRTNSLPTMAEAEAGNDPASPRSGAEVQPQGSGAPLNGVVAEPAALPRASLSPSPGSSDGQGKLRASLSPPSTGSSDGQGTITRTSSLPAGIEDGWRKRKLAHTLEKLGMKRRIETMNSSNVSGEDIGEKVENYDDPSMKSEQAGGMPKVQRMNHSNVRRRSSGLPPPYQPPAASQRSCLPGNPRRQNSALKGTPGAPERSLSSAVLPSSEGAKSTAVTTSSSSASAVRAASLVISKGEQQDGSERTAARASAADMMVRKMPPVYTSGLPNCERIDGFLYQYSRVDEVRIVCVCHGSFLTPTEFVAHAGGGKVANPMRHIVVNPPSSL
The following text describes a protein:
Function:
Acts as a dual histone chaperone and heat shock co-chaperone. As a histone chaperone, forms a co-chaperone complex with MCM2 and histone H3-H4 heterodimers; and may thereby assist MCM2 in histone H3-H4 heterodimer recognition and facilitate the assembly of histones into nucleosomes. May also act as a histone co-chaperone together with TONSL. May recruit histone chaperones ASF1A, NASP and SPT2 to histone H3-H4 heterodimers. Also plays a role as co-chaperone of the HSP70 family of molecular chaperone proteins, such as HSPA1A, HSPA1B and HSPA8. As a co-chaperone, may play a role in the recruitment of HSP70-type molecular chaperone machinery to histone H3-H4 substrates, thereby maintaining the histone structural integrity. Exhibits activity to assemble histones onto DNA in vitro.
Sequence:
MGLLELCEEVFGTTDLYRVLGVRREASDGEVRRGYHKVSLQVHPDRVGEGDKQDATRRFQILGKVYSVLSDKDQRAVYDEQGTVDEDSDVLSQDRDWETYWRLLFKKISLEDIQAFEKTYKGSEEELADVKQAYLDFKGDMDQIMESVLCVQYTEEPRIRNIIQQAIDAGEVPSYNAFVKESKQKMNARKRRAQEEAKEAEMSRKELGLDEGVDSLKAVIQSRQKDRQKEMDNFLAQMEAKYCKPSKRGQKKTTLKKEKK
The following text describes a protein:
Function:
Protein kinase involved in determination of morphology during the cell cycle of both yeast-form and hyphal cells via regulation of SWE1 and CDC28. Regulates pseudohypha formation, but is not required for septin ring organization or septum formation. Plays an essential role in virulence in a mouse model.
Subcellular Localization:
Bud neck. Note=In the hyphal cells, localizes at a potent septation site before the completion of septum formation.
Sequence:
MSTVVNRRSSHQFDSPSNHLDHSSSMNVDKVVQSVTNATKRLSQISTNTNNSNKKRKTQNKIGPWKLGRTLGRGSTGRVRLAKNTTTGQLAAVKIVPKSNFKKLENPKYKRSKEDATRLPYGIEREIIIMKLISHPNIMGLYDVWENKNDLYLILEYIEGGELFDYLIKRGKLQEYEAINYFKQIINGINYLHQFNICHRDLKPENLLLDFNKNIKIADFGMAALEVKEKLLETSCGSPHYASPEIVAGKNYHGAPSDIWSCGIILFALLTGHLPFDDENIRKLLLKVQSGKFNMPPELSFEAKDLITKMLKVNPRERITIDAILTHPLLAKYPEPTVSYSSTTTLDINSINIKQIESVDKIDKEILKNLSVLFHNCDEKTIISRLLSPNRCPEKMFYYLLMKYRNEHLSNSNSFNSSNDVDSARSLPRSTSYVKTTVTDHATGEKHTTVKKIQQSSSIYSNRSLLKKSTSAKGNVLSNITNRPNTPKQFSASSSFNKKKALHSKTQIYASRSRNASSRSLKSNSSTGRNGNNASVTSVNKIPEITGATVLQPIPSMAMNRGDEQQNKTKKNLTGTFGNKSLLNFQLICEEVFENDKENSKPVSKTPVSQLPPPPPPPIETPTSRTNSVKRGKTWSLARRERELAEQVRQRNEARENKLKAEELARKELEQEKKRIAEEKKRLEQQERELDEKQKLQEKQKAALEKLQKHQSAHDFEGLFASNRRSVTDMAPSSGMSSLDPRAHMVSRANTIGSPNLSSSSVNIDENASKVLHKFGIDVAPSPKRFSRASKTSTSKNLSSFLAPTVSRNLSSQLKTSSSKNLAGYLHGTTDTNGSAIAAKKKDNSTNKALTIEEFNAKERTSMSPSISKASVNKRNSNQSSYYRSMFSDNGNDDNVTKVRTRESHLSVQEEEEMDMENAIDEDISLIPNPRFSRFSFGGLLGSNTVANEEGDWTIMNSTLNHSNTVVRRTHNKSSTMLGLGIKMRDTTTIKEDEEFEDEKPFISVPSSEDDEGNTHKNKRGGLRDSGNYDFDEEHSVASTANTEYSDVASQGQQRPGSHTIHQLETELSNFDLLSYRVADIGKVNKHKPSIVDSKETLLKNHSSDEATIEVKEDNNEHDFNDKIKQHYDDNGDSEEDDEDEDEEEEDDDDDDDARSSFEARPHSHNYSLAEITSESPVGGGYESPSIANDFKKSRHSTGIFSTTQFPRSPYVVNNNGDSNKDENSQQQTKHMLNDGHKGLITSPVQDTFGSKKPVESNSLFRRLSLNPNRAAPKAPAPPPPSAPTSSAAKANISQPLSSPTKGHNRFSRISIGSKNMLQKEDKSTKSNWFKKFFHSLTTPSTKEQSGNSSSKVASKDIKIIDTSLTAAQLIRVIKYQLELKKIEGSISKVDIDEEFGLISGVIPSKFANGRKLKFKIEVIDLINSSSLHVIKMKGNDKGFQSLVNIVTFIIKKEEQDKICRR
The following text describes a protein:
Function:
Hydroxycinnamoyl transferase that catalyzes the transfer of an acyl from p-coumaryol-CoA to spermidine, to produce coumaroyl spermidine. Can use feruloyl-CoA as acyl donor. Contributes to the natural variation of spermidine-based phenolamides in rice cultivars.
Sequence:
MKLDSFTARRGNPELVAPARATPRETKPLSDLDDHWDLRYLQPSLEFFRVVDGDRRPARPGDGIKAALAEALVYYYPIAGRLRELPTGHMLAVECTAEGVVFVEAEADVALEDFGEPLMPTFHGAEGFLCDVGDTRVIVGRPLFYLQITYLKCGGFVLGTYMCHCIADAFGTIQFLKAIVDIARGEAKPTTLPVWERELFLATSLQPHIKEDQKKLFDELESTTCDDIMVTMPTENMVSEYFILSQIDMAALRRHVPLNLNKTVTSFELLTAVTWRSRTIALGYRPCHIVRLMIVVNARGRWKKLPLGYYGNGLLCSVIETTVNDLCTNPLGHTIELVRKAKDEMKTEENMQLRVDLLPLWREKPYIKVQRIFEACDIKWIGQDTLDIGWAKRIGGGIPTVSPPNLTSYQFLCKNEKGEKSTVISMLLPQPAMDRFKKEMAAWLIE
The following text describes a protein:
Function:
Mediates the negative regulation of osmotic and salt stress tolerance through regulation of the jasmonate and abscisic acid signaling pathways and modulation of the raffinose family oligosaccharide metabolism pathway.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MAAAAAAATVEAVGVAGGRRRRSGSVALGDLLRREASAERASASASAGAGGRERERRPSVAAGQACRAKKGEDFALLKPACERLPAGGAPFSAFALFDGHNGSGAAVYAKENILSNVMCCVPADLSGDEWLAALPRALVAGFVKTDKDFQTRAHSSGTTVTFVIIDGYVVTVASVGDSRCVLEAEGTIYHLSADHRFDASEEEVGRVTECGGEVGRLNVVGGAEIGPLRCWPGGLCLSRSIGDQDVGEFIIPVPYVKQIKLSSAGGRIIISSDGVWDALTVDTAFSCARGLPPEAAADQIVKEAIASKGLRDDTTCIVIDIIPPEKISPTVQPAKKAGKGLFKNIFYKKATSDSPCHADKDQCTQPDLVEEVFEDGCPSLSRRLDSEYPVRNMFKLFICAICQVELESGQGISIHEGLSKSGKLRPWDGPFLCHSCQEKKEAMEGKRHSRDSSSRNSGSSE
The following text describes a protein:
Function:
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus, nucleolus.
Sequence:
MRLFVSEGSPGSLPVLAAAARARGRAELLISTVGPEECVVPFLTRPKVPVLQLDSGNYLFSASAICRYFFLLCGWEQDDLTNQWLEWEATELQPVLSAALYCLVVQGKKGEDVLGPLRRVLTHIDHSLSRQNCPFLAGDTESLADIVLWGALYPLLQDPAYLPEELGALQSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPQPLPPEGRAVSNEPEEEELATLSEEDIIAAVAAWEKGLENLPPLQPQQHPVLPVPGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKAMEEGLTPQEICDKYHAIHVDIYRWFNISFDTFGRTTTPLQTKITQDIFQRLLTRGFVLQDTVEQLRCEQCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAIELKLEKRLEDWLGKTMPGSDWTPNARFIIRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHGLVFPCSALGAEDNYTLVKNLIATEYLNYEDGKFSKSRGIGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLIKNNSELLNNLGNFINRAGMFVSKFFGGCVPEMVLTHDDRRLVAHVSWELQRYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGDEMDRQRAGTVTGMAVNIAALLSVMLQPYMPTVSSTIQTQLQLPEAACRILATSFICTLPAGHRIGTVSPLFQKLENDQIENLRQRFGGGQAKGSPKPAVVEAVTTAGSQDIQVLVDEVTKQGNIVRELKAQKADKNQVAAEVAKLLDLKKQLALAEGKPIETPKGKKKK
The following text describes a protein:
Function:
Component of the ASTRA complex involved in chromatin remodeling.
Miscellaneous:
MISCELLANEOUS: Present with 721 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNSDTNAFKDIRISCVELSRIAFLPTESFDPNSLTLLACLKKVEEKLSAYEDDSLSPKFADYVFVPIASLLKQPALGESQTEYVLLIIFHLLRTCWSSNGKFSEQLGQQLFPLITFLVSSDKDNQKLITRSDEFKYAGCLVLHQFFKSVRSQRYHKEFFSNSKPNLLPALGHSVTILLKILEQSPQNNELQFKALASLEVLFQDIISDGEMLSFILPGNVSVFAKILTKPGRQIHYKVCVRTLEVLAKLLVLVYDDFSLDIKVNKLTDIRELSDTKLKHEINQSFMFNGPIVLLRTDGKTHRDTSWLTATSGQINIALEAFIPKLLKRNNESIDEALATFVSILLTRCENSLNNCEKVLVSTLVHLERDPMSKLPSHLVKLKEVVNEDLHKLSDIIRFENADRLSSLSFAITILEKNNERDTMINEVVRCLFESLNESIEPPSLINHKERIIEQSSQLTTTVNFENLESTNALIALPRLSEDMSLKLKKFTYHMGSLLLERHILNDVVTELISEQVDSPRTQKIVALWLSTNFIKAMEKQPKEEEVYLQFESDANYSSSMVEEVCLIVLEFCNELSQDISMEIEGKGIKKSDEFAVCTVLFSIETICAVMREEFQPELIDYIYTVVDALASPSEAIRYVSQSCALRIADTLYHGSIPNMILSNVDYLVESISSRLNSGMTERVSQILMVICQLAGYETIENFKDVIETIFKLLDYYHGYSDLCLQFFQLFKIIILEMKKKYINDDEMILKIANQHISQSTFSPWGMTDFQQVLNILDKETQVKDDITDENDVDFLKDDNEPSNFQEYFDSKLREPDSDDDEEEREEEVEGSSKEYTDQWTSPIPSDSYKILLQILGYGERLLTHPSKRLRVQILIVMRLIFPLLSTQHNLLIREVASTWDSIIQCVLCSDYSIVQPACSCVEQMIKYSGDFVAKRFIELWQKLCQDSFILKELRIDPTVHNHEKKSISKHVKFPPVTENALVSMVHMVLEGVKITEYLISEAVLEQIIYCCIQVVPVEKISSMSLIVGDIVWKIRNIN
The following text describes a protein:
Function:
May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MNTFLLLLTISLLVVVQIQTGDLGQNSTAVTTPANKAATTAAATTKAAATTATKTTTAVRKTPGKPPKAGASSITDVGACTFLFFANTLMCLFYLS
The following text describes a protein:
Function:
Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.
Subcellular Localization:
Secreted.
Sequence:
MRFLPCIATLAATASALAIGDHVRSDDQYVLELAPGQTKVVTEAEKWALRAEGKRFFDITERASSLELASNKKQKLAVTYPDSVQHNETVQNLIKSLDKKNFETVLQPFSEFHNRYYKSDNGKKSSEWLQGKIQEIISASGAKGVTVEPFKHSFPQSSLIAKIPGKSDKTIVLGAHQDSINLDSPSEGRAPGADDDGSGVVTILEAFRVLLTDEKVAAGEAPNTVEFHFYAGEEGGLLGSQDIFEQYSQKSRDVKAMLQQDMTGYTKGTTDAGKPESIGIITDNVDENLTKFLKVIVDAYCTIPTVDSKCGYGCSDHASATKYGYPAAFAFESAFGDDSPYIHSADDTIETVNFDHVLQHGRLTLGFAYELAFADSL
The following text describes a protein:
Function:
Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA.
Sequence:
MTGPLAAARSVAATKSMTAPTVDERPDIKKGLAGVVVDTTAISKVVPQTNSLTYRGYPVQDLAARCSFEQVAFLLWRGELPTDAELALFSQRERASRRVDRSMLSLLAKLPDNCHPMDVVRTAISYLGAEDPDEDDAAANRAKAMRMMAVLPTIVAIDMRRRRGLPPIAPHSGLGYAQNFLHMCFGEVPETAVVSAFEQSMILYAEHGFNASTFAARVVTSTQSDIYSAVTGAIGALKGRLHGGANEAVMHDMIEIGDPANAREWLRAKLARKEKIMGFGHRVYRHGDSRVPTMKRALERVGTVRDGQRWLDIYQVLAAEMASATGILPNLDFPTGPAYYLMGFDIASFTPIFVMSRITGWTAHIMEQATANALIRPLSAYCGHEQRVLPGTF
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MMIFSTAVLRLCATSRIGAVTKRASSTFLSSASSSSSSSSPTQSMPPQRYTHHQFQRHSYSTTTTTLQQQQQPSPPLSTAQLVKQLRLLTGAPMLECKKALASPDVNNDLALAQEWLRKHSSQKIGSKVAGREALEGLVGVCIDNCDGGSRGVLVKVASETDFASRSEVFTGLVQEIADAAAAAAGDGGDIVDIPTFLSNTQSITTGKLLSECLNDAVLSIRENIQLDSIVTIGTTPSSRSVIAGYVHGRAPNSTCGTSAALVEVEVLPKDGGGGDDAVLSEEEKSVAMEAAKKLAMHVVASNPLYLNPESVPVDVVEKEREILMEKMTDSNKPPEIIEKIISGQLRKFYEGICLTEQSHLVEEGNPKISKVMKGLGLVVKDFRLVGMSK
The following text describes a protein:
Function:
Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
Subcellular Localization:
Cytoplasm.
Sequence:
MDKKIVIPGDLLSENQKKAGYGTYVKNDKIYSSLCGIENLKEDKVGVIPLAGAYIPSANDVVIGIVIVVTPSNWIFDIAAPYDGLLHVSEYPRRVESREMPEILNVGDSVILRVKDVDSSMKVELALRDPSLHKLKTGQIIKVESVKVPRVIGHGGSMISMLKKETNCSIFVGQNGRIWIDGKDEDIELLSKALRKIELEAQRSGLTDRIYNFLKNERIRQKESKPVGFFKNETEGVTATKEDHSEEIYRKIDVLLDPKN
The following text describes a protein:
Function:
Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
Subcellular Localization:
Cytoplasm. Mitochondrion intermembrane space.
Sequence:
MSTLAAASCDSESSEKPAEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALGFKI
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MYSRPKVLITYCRKRRNSISLPTSIPDMVEDVAIQENKTKSTNVDATLPDECTVFASKTRSRQMYPRPRVLITYCRKRKRNSVSLASIIPAIVEDDVIQESKAKSANVDITLSSERSEFIEVNDFSIITRSQQVHPRPRILITYFRKRRRNSTILGNSLPAFVEKVGSCAVIPENRTQVTNSGPLSLSCCSGILEEEVITREEMVSVGAQQILVKAAGESSSVKHWNEKKILAVDNSTENSNNSACDTIKNVADIAEFPEDGYASACAFGSSTNEIFDGERESLAESNSSCSRLCAFIDEKNEITDVVTVPPLRRALNGRSNKKLLVLDLNGLLADIVPLQHVPYGFKVDAIVSGKAVFKRPFHDDFLQFCFEKFNVGVWSSRIRKNVELVLDFLLGNAKEKLLFCWDQSHCTDTGFPVVGKRRDKPIILKELKKLWEKFEPDLPWERGEYDESNTLLLDDSPHKALCNPPNTAVFPNTYLYTDEKDASLAGPEGDLRVYLEGLSMAENVQKYVESNPFGQRSITERNASWRYYCKVIEAATCIPEHSGVNRFST
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MEEAEARPAPPDPNDARQRFLLELEFIQCLANPTYIHYLAQNRYFEDEAFIGYLKYLKYWQRPEYIKYIMYPHCLFFLELLQNANFRNAMAHPASKEVAHRQQYFFWKNYRNNRLKHILPRPPPEPTPTPAPAPAAVPPSASVPSTVVPPVAAPPSALLPMSAAGASAMSPMQFAGTPGTNIPKNDMRNVMGGQGGRKRKIG
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MIQGPTVVSLFQTTGEEREKARKQLVQKLKILEEHALGDKKFSGGEAINLVDIEFGVLAHWVEGMEEVMGLQLLKPGTLPQLRQWIKNFKEVAVIKENLPDKAKLLAHMKVVRELFVFNVSG
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSCSRLSSTGNRLLGCAAHRRTRPEAQAAEMDPVTFTDVAVNFTEEEWALLDSTQRNLYRDVMLENCRNLASVDLMSQHKTQNSTPQQDILAKKTLDEANRVCAVNNSSQFSLLGKDWKCHETDEPPKQREQKFKQVAAVHKKGESPVNICGYHEMRDNFIPSSNLGPSWRDSTRNCIQTCASNIVKQNPVLTSNPKMYRNNKYDRVLWPSIELTPLVGYRTESESHTWTDNQNNVLHIRKNICMGVDVHEWDPFGKAFGEDISLRTYRTHAEEKTYESNPCEITFQNSSIHDVQRQSCTTEANHENNQGDKTFAHIANSDSNRKTKTRRGKYKCQDCRKTYVYQSFLMKHMKIHTGEKPYECKTCGKAFRYSLHLNKHLKKHNMKKPYKCGACGKDFSKSSKLNEHRRVHSTEKPYKCEECGKAFTNSSRFKNHLKTHS
The following text describes a protein:
Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MDGLTLSSSIGQAKSYASTPFGAVRQKMPPSGSRSLHTSRPLSAAVANRPLSPHLPLKKPQLSATFSISHRIFGVALGAAIISIPLATKFSLMFGV
The following text describes a protein:
Function:
Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1.
Subcellular Localization:
Nucleus.
Sequence:
MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIITACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARGLRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKILEPEEGSEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEISKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGGTWPAGQVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE
The following text describes a protein:
Function:
Transcription activator that recognizes the motif 5'-TAACGG-3' in the promoter of target genes. Promotes vegetative-to-embryonic transition and the formation of somatic embryos from root explants in a WUS-independent manner. Together with MYB118, activates the transcription of S-ACP-DES2/AAD2 and S-ACP-DES3/AAD3 thus promoting the biosynthesis of omega-7 monounsaturated fatty acid in seed endosperm.
Subcellular Localization:
Nucleus.
Sequence:
MYHQNLISSTPNQNSNPHDWDIQNPLFSIHPSAEIPSKYPFMGITSCPNTNVFEEFQYKITNDQNFPTTYNTPFPVISEGISYNMHDVQENTMCGYTAHNQGLIIGCHEPVLVHAVVESQQFNVPQSEDINLVSQSERVTEDKVMFKTDHKKKDIIGKGQWTPTEDELLVRMVKSKGTKNWTSIAKMFQGRVGKQCRERWHNHLRPNIKKNDWSEEEDQILIEVHKIVGNKWTEIAKRLPGRSENIVKNHWNATKRRLHSVRTKRSDAFSPRNNALENYIRSITINNNALMNREVDSITANSEIDSTRCENIVDEVMNLNLHATTSVYVPEQAVLTWGYDFTKCYEPMDDTWMLMNGWN
The following text describes a protein:
Function:
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSMLPPKSPSVKRFTQNAEKRSTSPSPSSLLMNLNTPSLAAPKQPKVVLGVCAMDVKARSKAMREILTRLVDIEKGGLEVKIFGDVVILEEDISHWPPVDVLISFFSTDFPLPKAISYTQLPNRPPPISINSLSMQSLLWDRRLVLAILDHIGVPTPSRAEISRDGGPRIPRSLRRQVRRELGLVLPGPKAKDEDEWGEAIIPEKWRGKQRKDPVPKATEVILREDGDAILIGDKVIEKPFVEKPVDGENHNVFIYYKGGGGRRLFRKVGNKSSEYDPNLYHPRTIGSFIYEEFINVDNAEDIKVYTVGSKFSHAETRKSPVVDGLVRRNADGKETRFITPLSEAENQYARDVVEAFGQRVCGFDLLRCEGGSRSMVIDVNGWSFVKGNQAYYDKAAEILSGVCQIARERKVQGIQAGLASTATIDDPSGGSTTSTLRATVTVLRHADRTPKMKLKFSFPAHEAWSRPFLRLLRGHREEIILRDTRQLQYILAAAEESSQTPGITEEQLIKLSQIKEALGKKMSFPGTKAQLKPSFAKKKGDKNEKKDKKKKDEDKEDEGDITETEGRKKVNDWLRKGESAQAATADSTLLTEPPMSATDSIDAMPRSGTPCNPEPETDQNEMAQGKHAGCVSDPDIPEGLEKMQLVVKWGGESTHSSRYQSRDLGDAFKKDIMIMNKDVLNNVKIYTSSERRVINTAQIFAHALLGVEGGSSSSASSIANARNPPEQGPQISHLIQRRDLLDDNNAAKDLCTDAKKKLKMLLRTGETERRPDLAWPKSFKKEPVEVVSDVIEQLTELRGIMRRNYENGNVEKIPQQRWCSGDSPWLFKERWEKIFDDWVGVKQEKFDPSRVSELYDSIKYDSLHNRTFLFAVFDPEGKGQASKAGAPNQDRRLHDLFGRAKALFDLVAPQEYGFDAEAKEEIGVLTSLPLLRKVWEDLDEAKTTGKSLACFYFTKESHITTFVHLLLASGLPFTNVRIPELDYCSHCTIELWEKSTGSGQKDFSIRLSISEGAHSPAVLDSNVDARHSLTVQPRKKLSSHIDYERARQCFSKHFNKGLSFSTTPLEGDEVYLKKSIEDESVLPLSSLHHKAGDETPKMISSASSDRSHPGASDGGW
The following text describes a protein:
Function:
Regulates protein folding in the endoplasmic reticulum lumen. Probably acts as a J-protein for the Hsp70-type chaperone KAR2 by stimulating its ATP-dependent reaction cycle and initiating folding reactions. Also involved in the endoplasmic reticulum-associated degradation (ERAD) process. Cooperates with KAR2 and another J-protein JEM1 to facilitate the export of ERAD substrates to the cytoplasm by maintaining them in a translocation-competent state and preventing their aggregation in the endoplasmic reticulum lumen.
Miscellaneous:
MISCELLANEOUS: Present with 8260 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MIPKLYIHLILSLLLLPLILAQDYYAILEIDKDATEKEIKSAYRQLSKKYHPDKNAGSEEAHQKFIEVGEAYDVLSDPEKKKIYDQFGADAVKNGGGGGGPGGPGAGGFHDPFDIFERMFQGGHGGPGGGFGQRQRQRGPMIKVQEKLSLKQFYSGSSIEFTLNLNDECDACHGSGSADGKLAQCPDCQGRGVIIQVLRMGIMTQQIQQMCGRCGGTGQIIKNECKTCHGKKVTKKNKFFHVDVPPGAPRNYMDTRVGEAEKGPDFDAGDLVIEFKEKDTENMGYRRRGDNLYRTEVLSAAEALYGGWQRTIEFLDENKPVKLSRPAHVVVSNGEVEVVKGFGMPKGSKGYGDLYIDYVVVMPKTFKSGQNMLKDEL