lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores.
Subcellular Localization:
Endoplasmic reticulum-Golgi intermediate compartment. Nucleus.
Sequence:
METAKDGEQSPSEASPPTQAGPETISEPVPLEEEGQPLYHEETIDLGGDDFASEETEPTSEGSHNFGDKLNEHMMESVLISDSPNNSEGDVGDLGCLQDVGEPPRGATDHRLPDSTDKEVVDTLSNGSETDGDDTPRDISDMTPDSRASLKEDSTQEDVPAMPALENAGTEEVGPKDSLVPREEQTSEVSSSQSSSKDEPLPVCTIFSQATSTSSQPHLFLQDGFESQMVKSPSFSSTSETSAKTPPPMVQPSPSLSTFFGDTMSSNSLASDFFDSFTTSTFISVSNPNAGSPVPEKLASLTAPVGEKSPDSTSPSYSTRMDRSESGVSRAALDVPESPKPFSQIQAVFAGSDDPFATALSMSEMDRRNDAWLPSQATREVLMSVATQQYGTVFIDKENLTMPGLKFDNIQGDAVKDLMLRFLGEKAAAKRQVLNASSVEQSFVGLKQLISCRNWRAAVDLCGRLLTAHGQGYGKSGLPTNHTTDSLQLWFVRLALLVKLGLFQNAEMEFEPFGNLDQPDLYYEYYPHVYPGRRGSMVPFSMRILHAELQQYLGNPQESLDRLHRVKTVCSKILANLEQGLAEDGGLSSVTQESRQASVQLWRSRLGRVLYSMANCLLLMKDYVLAVNAYLTVIKYYPEQEPQLLSGIGRILLQQIGDIKTAEKYFQDVEKVTQKLDGLQGKIMVLMNRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRHYLHESVLFNLTTMYELESSRSMQKKQSLLEAVASKEGDSFNTQCLKLA
The following text describes a protein:
Function:
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.
Subcellular Localization:
Lysosome.
Sequence:
MVWKVAVFLSVTLGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGDAEAVKGIGSGKVLKSGPQDHVFVYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKHKASSPLSLPPVTHLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASEAEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHRIKLSMDHVCLGHY
The following text describes a protein:
Function:
Guanine-nucleotide-releasing protein that acts on SEC4. Might play a general role in vesicular transport.
Miscellaneous:
MISCELLANEOUS: Present with 1500 molecules/cell in log phase SD medium.
Sequence:
MSKATCSFEGCHSAVITINDDNIINLPEQVHSEFKLLENRTMRDATPSESNFLVVPDVWDFDNVGVSREIPSSILGDLSDKSDFVFEYGNSSWKIKKCLKYLICADCDKGPIGIICKVQDQTKNEERVLHLLSLRSLQIMGRN
The following text describes a protein:
Function:
Involved in bleomycin tolerance with links to DNA repair and/or proteasome function.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFASAGQQHPQIVPKEEESILNYLLEVRSSLAKLKQNRTQYLNSKDVQTTYQHVLTKVRELDDIRKNSHETPAKSAATLIHSTELHNRVDSVLDDVFQLLSLCFLTVGLKNSAPATYASLSTVESLLEHLNESNVFTHHDLSPIKERLEEISKIVEQKNSSPAYDEDGNDDRLREIDNERKKNKIEEDLLLRAKLKHCKDEYDILEGKLEEIDPSLSTVMEKLFRIRRGLLSLVASAKKTMSKSDINTNSLLQEQNDLQTNNESLTDDKHLVSQEYVHEKLSVLKNELSELESNRDDSGKFKSLESHQVAEKGQSVLNGLLDDCHDLVNDLSHQKNGGLTLDPYLQPIYEQLIDIKTTLENLMITRRWTLRETDLFSYQKKLNEIDNKRINGKFPTKSQDSKGQSILLYLLRRCYAIIYKLLESSEPVSEALQPIHNQLSTVRRCLLELKRMGGVNNERELYPYQMKLASLDNLRTEGIFYDSDGNIPEGQGILNALLAECFDILHELKVEAEEKAQNSTSSDGSDDDDNGESGIDSNSNDSEPESEYQQE
The following text describes a protein:
Function:
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MRKAIFPGTFDPFTIGHYSVVERALTFMDEIIIGIGINENKNTYFPIEKREEMIRNLYKDNPRIKVMSYDCLTIDFAQQVEAQFIVRGIRTVKDFEYEETIADINRKLAGIETILLFTEPELTCVSSTIVRELLTYNKDISQFIPEGMEIN
The following text describes a protein:
Function:
Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.
Sequence:
MSAQVRLVSNDKKEFLVDVAIARMSDTIAGMLDIIPEDEIGKHPIPLNNFDAEVLERVLEWCEQHRHDPVDTKEEIHDGREIDLSVPEWDKQFLQNKSAEEIREYFHVENDYTEAEIKKIKEDQAWH
The following text describes a protein:
Function:
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Subcellular Localization:
Cytoplasm.
Sequence:
MVHNKNNTILKMIKGEETSHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTHLPVDNYHTDAAILYKDIMTPLKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDVPYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSKNYNFTKAMMYRDEATWFALMNHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKEKHDVPVILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEERLKPILDQGMENGKHIFNLGHGVFPEVQPETLRKVSEFVHTYTQR
The following text describes a protein:
Function:
Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.
Sequence:
MWRERVYNGTLRPKTEEVITGGYLSDLLDGLNYTVPTNYSTRLSEAHDVNFITTGLYLGDKYAAKDRRFLQRNGFTHVLNAAEGIDEYQVNTNQYYYKDAKITYLGIPGHDRPSWNISVYFDVAARFIDQAVKSGGKVLVHCVVGISRSATFVIAYLMIYKGMNAAEALDFVFKKRRVYPNPGFLSHLAQLNSVLNKTRQPTFKSYLL
The following text describes a protein:
Function:
May function as a transcription factor involved in light regulation. Binds and affects blue light regulation of the al-3 gene. Wc-1 and wc-2 interact via homologous PAS domains, bind to promoters of light regulated genes such as frq, and activate transcription. May bind directly to frq.
Subcellular Localization:
Nucleus.
Sequence:
MSHGQPPPGSSMYGFGAMGMGSGMGSGMGSGMGTGMGTGMGTGMSASQMTSDPQDMMSLLDTSVFPGFDGMSMSLDVGDSMSNPFTPVSVPPPLPAGNAGPSHVGVCGGHGAPDQLFSPDDLIATSMSSAGPMIATPTTTTSGPSGGPSSGGGSTLTEFTKRRNWPAKVVEELQDWEHILDANGRIKHVSPSVEPLTGYKPPEIIDLFLRDLIHPDDVGVFTAELNEAIATGSQLRLFYRFRKKDGNWTIFETVGHAHIAAAKFAPNPQNQSPFCQAVFMMARPYPTKNAGLLDSFLEHKIENERLKRRIAELRREEQEEQEESHRTWRMSQEGRSDVTPSDDTATQMGMTPFYIPMNAQADVMMPPPSQPASSLNIALTRENLEGIAGSRPDSIREKMLRYEGNHADTIEMLTGLKYQEGERSHGITTGNASPTLIKGDAGIAIPLDRDPRTGEKKKKIKVAEEYVCTDCGTLDSPEWRKGPSGPKTLCNACGLRWAKKEKKKNANNNNNGGGIGGHNDIHTPMGDHMG
The following text describes a protein:
Function:
Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer. Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1.
Sequence:
MSASLSRAAAALLRWGRGAGGGVLPRAGVRAASSGGQAEQLDALVKKDKVVVFLKGTPEQPQCGFSNAVVQILRLHGVRDYAAYNVLEDPELRQGIKDYSNWPTIPQVYLNGEFVGGCDILLQMHQNGDLVEELKKLGIRSALIDEKDQDSK
The following text describes a protein:
Function:
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Involved in the salvage pathway for NAD(+) biosynthesis via NMN.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDQAKKYANLLDSFRSSTEDILLLERLEVSDKPIYVLDSSFNPPHFAHLGMCLSIPKGSQLLLLLSITNADKPVAPAAFNERILMMEKLKTLIHNCTVSVAICKHALFVDKCRSISNKLGPREQVYLVGFDTLIRILDCKYYKEKAMQQVLQPFFSCSQILCFSREVDGTTTDDQAQYLEKIKKSLLPNIPSQWSEKIKLTKLKGNVGFGVSSTRARQAIISGDEETQRKIIPQEILNVIKVIQPYRHR
The following text describes a protein:
Function:
Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.
Sequence:
MHETSHKSNTEIENKCDENNSLDSGHESNVTGLKKPKTPDNHLPVSSNAEEIPAQLNSEPEPAEQPTKQPSSLPPQLAPFTNSTTDDLQGATGVGPDNNGEGRESIYNVKWIRFNQVSLPIVTQNENGPCPLLAIMNYLFLQQRVQLETRSNIIPSSQLISLLADYIFEHVPNRIQPNTRLNYEQKMHDAIAMFPNLQTGLDVNVRFTGVSHFEYTPSSEIFDLLDIPLYHGWLVDPESEEVLEAVSNATYNQLVEMVINQKCSSQFDLAEKALIAEEFLNATASQLTYHGLCELASALRDSDMGVLFRNNHFHTLLKHDGALYVLATDQGFLNEPRVVWETLTNVEGDSHFCDANFRIFQSPSETKNPDQIDQDYFVALSMEQEQEENSQSVSNWTDLGLTDEELAMRLQEEENSLASQADNRQQHSAGATGSSRDQGTTRNISKVTTDAKPKKDSLVSRNFLINFKIKLRQRKMFRKVIFEIPSAQKIFHLFLILFQI
The following text describes a protein:
Function:
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Major enzyme required for hyperosmotic shock-induced turnover of PtdIns(3,5)P2 and requires VAC14 for this function. In vivo, mediates turnover of PtdIns(3,5)P2 at the vacuole membrane necessary for vacuolar size control. In vitro, catalyzes the removal of phosphate from the fifth hydroxyl of the myo-inositol ring of phosphatidylinositol 3,5-bisphosphate.
Miscellaneous:
MISCELLANEOUS: Present with 339 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein. Note=Localized to the limiting membrane of the vacuole. Localization requires VAC14 and FAB1.
Sequence:
MNNDAMEHTLGGGILTTSGSKQRKTSKFVMGKYTLYETKDRMYIVGSNKRETMFRILEIDLTVPRGELTVLEDNVFFTRNEIMNVLASLEEATEDGLHKKITGYGLLGFIKFTCWYYLIMVTKYSQVAVIGGHGIYHIDGIDIIPITNNYKKPEKSSDEARLLNIFKDLDLTKTFYFSYTYDITNTLQTNILREKLKAVDRCDITIPCGITDYNEMFVWNNNLLSPIFACIDTVFDWFQCIIHGFIDQVNVSVLGKSIYITLIARRSHHFAGARFLKRGVNNKGHVANEVETEQIVTDMILTPFHQPGNGFFDSDRYTSFVQHRGSIPLYWTQDASNLTTKPPIRINVVDPFFSPAALHFDNLFQRYGGGTIQILNLIKTKEKTPRETKLLWEFEQCIDYLNEFLPTLKKLDYTSWDMSRASKQDGQGVIEFLEKYAVNTVTTTGIFHNGPDFASTKIQEGICRSNCIDCLDRTNAAQFVIGKRALGCQLKSLGIIDNSYLEYDSDIVNILTELFHDLGDTIALQYGGSHLVNTMETYRKINQWSSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGHYSWREGFPSLWEMNTDFYLHNAYSLNMPKRSYIHWWNDYNIKSVKELINEELIATGNDVTREKIIKNVRGYPGAFDNYWNEYYLPRSVTWIRDLFAYNMNSTRRYHNALSKQDKAMSPFTSRKQSWLNNKLKMITSSKSLEKAEGRVVETTDLDRDTSPKQELELYEHYLHIISDRSQKLEEKMNSFSYSKYPIFISHESSEIPPMRKVIGEPLVDIAEDFTDVYDDDDDGDDENDEMTTEALLIAPDHVSVDEKFYEKVLNVDDYKPALDDYSAVIHIKPDNLQLYRDLCFSKDIQLDFQ
The following text describes a protein:
Function:
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.
Domain:
Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.
Sequence:
MEYDTFSATQYNTSDPTSFAHTSARERWPIIITQGIDDVHRSTHSAQDEETQSEGKWIVSELARLKYELQHDRELTPIPDDGEKDVEAYNKELAARGTPKWHSVPWLYSECYLYRRISSIFKRTKKWRSYDLFARQKMSTFKSSRPAVVELAARYRDIVTELESKHTIKGAETEEQLEAAEQILFTEMCEICLWGNATDLSLLTNLSYEDIQKLQGSQARKNSEKNILVNDLSKAFKVLRAAQKEGKKERRVDIVLDNAGFELFVDLILAGYLVASGLATTVVLHPKSIPWFVSDVLPADFIALLSALAAPQNFYGTQSEEDKNAGKEAVPLSETEDSNLQFLFQNWSQMHAEGQLMLRPNDFWTAGGSYWRLPKAEPDLLEDLKESELVIFKGDLNYRKLTADAEWAPTTPFTDAIGPMGPGSGVRVLALRTCKADVVVGLPEGEDERIRDITGGEKTGARKWAWSGKYAVVQFSDDRHGGPSKVIHEEEAPRIHFQPRTFF
The following text describes a protein:
Function:
Involved in the positive control of both endoplasmic reticulum (ER) and mitochondrion inheritance during cell divison. Required for the MYO2-dependent retention of newly inherited mitochondria at the bud tip in developing daughter cells.
Miscellaneous:
MISCELLANEOUS: Present with 2850 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Bud tip. Bud neck. Note=Enriched in the peripheral ER of small buds and daughter cells. Concentrates at the site of bud emergence, at the bud tip of the growing bud, and at the bud neck during M phase. Interaction with MYO2 is required for proper localization to the bud.
Sequence:
MSQRKRYSLNVVTSPSIPSPTPSAPIRTNESNWEAASPASAASSFLPNVHHGGTVLNPGLGIMRSPSLNKSGAFGRSGSSGSSTVIEPSNIKLLLIGDANVGKTAMILSYCRELLTRAEMSRSARLRHQQQQQHKDLGLKKTVVNHRLSMKEKRKRYSSNDFEKEFKDINHFADETSDFGNPNIGDDNNHEMADPNEIVIETRSTIGIDIKTNLVNIDNRFFNVILWDTAGQERYQNAIIPSLYKKTNAVILTYDITNAKSFQSCMERWIVQALENFSSQDLLKARFFLVGNKIDLYKERQVTHYDVVQMVQEMQLKHGIKISGNFEVSCKWVNVVERTMNMIILDLVENGCFENNDPCVSITTSDDVQGHEQEFHDTVEEPFNFTRQRQHQLEKNNTVDITKPNDDIANNQSICCV
The following text describes a protein:
Function:
Required for growth within macrophages. Catalyzes the phosphorylation of PtpA on the tyrosine residues at positions 128 and 129, thereby increasing PtpA phosphatase activity and promoting pathogenicity. Also phosphorylates the thioredoxin reductase TrxB.
Domain:
Composed of two domains: the N-terminal highly flexible intrinsically disordered domain (IDD) and the C-terminal rigid kinase core domain (KCD). IDD is unstructured and highly dynamic, allowing transient interactions with the rigid KCD. This interaction modulates the accessibility of the KCD active site. In closed state, IDD masks the autophosphorylation site, thereby decreasing the activity of PtkA. In open state conformation, IDD is away from the autophosphorylation site, making it accessible for phosphorylation and activation of PtkA. Phosphorylation of PtkA by serine/threonine kinase induces conformational changes of IDD, which promotes the open state. IDD had a greater inhibitory effect on the catalytic activity of KCD in the presence of the drugs esculin and inosine pranobex.
Sequence:
MSSPRERRPASQAPRLSRRPPAHQTSRSSPDTTAPTGSGLSNRFVNDNGIVTDTTASGTNCPPPPRAAARRASSPGESPQLVIFDLDGTLTDSARGIVSSFRHALNHIGAPVPEGDLATHIVGPPMHETLRAMGLGESAEEAIVAYRADYSARGWAMNSLFDGIGPLLADLRTAGVRLAVATSKAEPTARRILRHFGIEQHFEVIAGASTDGSRGSKVDVLAHALAQLRPLPERLVMVGDRSHDVDGAAAHGIDTVVVGWGYGRADFIDKTSTTVVTHAATIDELREALGV
The following text describes a protein:
Function:
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Sequence:
MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILEEYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLSEHIS
The following text describes a protein:
Function:
Plays a role in embryo pre-implantation development.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MSRLIVKNLPNGMKEERFSSMFAAFGTVTDCSLKFTKDGKFRKFGFVGFKSEEDASRALKHFNRSFVDTSRVTVEICKAFGDPTKGKAWSKHTQSAGQEKPSGPAPTEGKKKRNQKKDTAIGLGNLEEDQEFKEFLSVHQNRSQAPTWANDAVQGAADPERGPAKSKKKKKSASDDYLNFDSDQSEDEDRSLDDDDDDHNDDDNNEAGAKEALKSGLSDMDYLRSKMAPIEDTKDEDEDNDDDSAVQHANSAYESGDRENTAKTKSSSESMRPSKAKKTATQEMEPATEFTVKLRGVPFSVKEQQIKEFMTPLRPAAIRIGKNESGQRTGYVYVDLHSEEEVNKALKKNKDYIGGRYIEVFKVDHSGGKAKKDPKDKEPDFNFTRKLKEDEEEEDVSETGRLFVRNLPYTCTEEDIRELFSKHGPLSEVLFPIDNLTKKPKGFAFVTYMIPENAVTALAQLDRHVFQGRMLHLLPSTVKKENPESSDAGGPGSSSYKRQKDAKNKASSSSSHNWNTLFLGTNAVADAIAEKYNTTKSQVLDHESKGSLAVRMALGETQIVQETRQFLLENSVSLDSFSQAAAARSTTVILVKNLPAGVTTSELEELFSPHGSLGRVLLPPSGLTAIIEFLEPTEAKRAFTRLAYSKFHHVPLYLEWAPVGVFVADQQKTVSNKEETVKEKKDLEKEEEDEEEDAVPGSTLFIKNLSFITTEEKLQETFSKCGKVKFCSISKKKDKSGKLLSMGYGFVQYQSAEGAQKALRQLQHCSVDDHKLELKISDKATRATETSRKKKQAEKKQTGSKILVRNVPFQATVREIRELFCTFGELKTVRLPKKAAGSGNHRGFGFVDFITKQDAKKAFAALCHSTHLYGRRLVLEWADAEETVEALRRKTAEHYHVSAKKSRQSKVLEGIMETMETEGRTEN
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MRESSHSFLMFRNMDRTNRGGGSIETLLRNYKLGKTLGHGSFGKVKIAEHVLTGYKVAVKILNRRKLKNPEMEEKVRREIKICRLFVHPHIIRLYEVIETPLDIYVVMEYVKSGELFDYIVEKGRLHENEARKIFQQIISGVEYCHRNMVVHRDLKPENILLDSRGNVKVADFGLSNIMRDGHFLKTSCGSPNYAAPEVVIKFASRVWLAKEMEWNGVSNDTLESPIPVPWDPQTKTHPKFLILIKNIYCYNRILKLVPFMQVVSGKLYAGSEVDVWSCGVILYALLCGTLPFDDENIPNLFKKIKSGIYTLPSHLSAGARDLIPRMLVVDPVKRITIAELRQHPWFKAQLPRYLAVPAPDATDHLKKLDEDIIRKVLNMGFERAHLTQSLQTRIQDDATVAYYLLFDNQSRVAGGYLGAELAENLEGDLATMHLDNIPDRATMNNRFARNNSVRPNLPGERKWQVGMQIPANPREIMTRVLEILRDLNVCWKKIGLYNIKCRWLSSITHENHYITSGITPNVVKFEIQLYKTPEDSYLVDIQKITGPQLVFLDFCAAFILQLESGIL
The following text describes a protein:
Function:
Involved in the catabolism of the rings C and D of cholesterol. Catalyzes the ATP-dependent CoA thioesterification of 3aalpha-H-4alpha(3'-propanoate)-7abeta-methylhexahydro-1,5-indanedione (HIP) to yield HIP-CoA. It can also use the hydroxylated analogs of HIP, 5alpha-OH HIP and 1beta-OH HIP. It requires that the side chain at C17 is completely removed.
Sequence:
MINDLRTVPAALDRLVRQLPDHTALIAEDRRFTSTELRDAVYGAAAALIALGVEPADRVAIWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAPVLFAAGLFLGADRAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALDAVAARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITSDDRYLCINPFFHNFGYKAGILACLQTGATLIPHVTFDPLHALRAIERHRITVLPGPPTIYQSLLDHPARKDFDLSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRPEDDAVTVATTCGRPFADFELRIADDGEVLLRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAGNLRITDRLKDMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVGRAFVVARPGTGLDEASVIAYTREHLANFKTPRSVRFVDVLPRNAAGKVSKPQLRELG
The following text describes a protein:
Function:
Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown.
Subcellular Localization:
Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle pole. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Central region of the nuclear pore, within the transporter. During mitotic cell division, it associates with the poles of the mitotic spindle.
Domain:
Contains FG repeats.
Sequence:
MSGFNFGGTGAPAGGFTFGTAKTATTTPATGFSFSASGTGTGGFNFGTPSQPAATTPSTSLFSLTTQTPTTQTPGFNFGTTPASGGTGFSLGISTPKLSLSNAAATPATANTGSFGLGSSTLTNAISSGSTSNQGTAPTGFVFGSSTTSAPSTGSTGFSFTSGSASQPGASGFSLGSVGSSAQPTALSGSPFTPATLVTTTAGATQPAAAAPTAATTSAGSTLFASIAAAPASSSATGLSLPAPVTTAATPSAGTLGFSLKAPGAAPGASTTSTTTTTTTTTTTAAAAAASTTTTGFALSLKPLVSAGPSSVAATALPASSTAAGTATGPAMTYAQLESLINKWSLELEDQERHFLQQATQVNAWDRTLIENGEKITSLHREVEKVKLDQKRLDQELDFILSQQKELEDLLSPLEESVKEQSGTIYLQHADEEREKTYKLAENIDAQLKRMAQDLKDIIEHLNMAGGPADTSDPLQQICKILNAHMDSLQWVDQSSALLQRRVEEASRVCEGRRKEQERSLRIAFD
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Cytoplasm.
Sequence:
MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTFHRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFIVHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG
The following text describes a protein:
Function:
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of pro-inflammatory cytokines. In addition, induces B-cell proliferation and differentiation in the presence of T-cells. Causes also the intoxication staphylococcal food poisoning syndrome.
Subcellular Localization:
Secreted.
Sequence:
MKKFNILIALLFFTSLVISPLNVKANENIDSVKEKELHKKSELSSTALNNMKHSYADKNPIIGENKSTGDQFLENTLLYKKFFTDLINFEDLLINFNSKEMAQHFKSKNVDVYPIRYSINCYGGEIDRTACTYGGVTPHEGNKLKERKKIPINLWINGVQKEVSLDKVQTDKKNVTVQELDAQARRYLQKDLKLYNNDTLGGKIQRGKIEFDSSDGSKVSYDLFDVKGDFPEKQLRIYSDNKTLSTEHLHIDIYLYEK
The following text describes a protein:
Function:
Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPAGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKIREESNTKIDLPAENSNSETIIITGKRANCEAARSRILSIQKDLANIAEVEVSIPAKLHNSLIGTKGRLIRSIMEECGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDSTGARVIFPAAEDKDQDLITIIGKEDAVREAQKELEALIQNLDNVVEDSMLVDPKHHRHFVIRRGQVLREIAEEYGGVMVSFPRSGTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTLECAIPQKFHRSVMGPKGSRIQQITRDFSVQIKFPDREENPVHSAEPVVQENGDEAGEGREAKDSDPGSPRRCDIIIISGRKEKCEAAKEALEALVPVTIEVEVPFDLHRYVIGQKGSGIRKMMDEFEVNIHVPAPELQSDIIAITGLAANLDRAKAGLLERVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGRKGAVITQIRLEHDVNIQFPDKDDGNQPQDQITITGYEKNTEAARDAILRIVGELEQMVSEDVPLDHRVHARIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILNLEEEYLADVVDSEVLQVYMKPPAHEEAKAPSRGFVVRDAPWTASSSEKAPDMSSSEEFPSFGAQVAPKTLPWGPKR
The following text describes a protein:
Function:
Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form.
Sequence:
MARRTDRAPLLDWAEGPGVSPAPETEQGERWAQGYGAAWERRPAGELTPLPQLEDDHIAAVFVVTFDPRSGNIVEWCRPHDIDLEGVEFKSMASGSHRVQSDFIYFRKGGFFGLACFANMPVESELERGARMKSVGVLSPSYTLLYRYMHFLENQVRHQLEIPGHYTPLEAFYEDKKGVLPVGPQTCQPALHWLPPVHKHLYPEMKITHPAGCMSQFIKFFGEQIFVLWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVTLPGIGATAPESKPFFYVNVADIQTLDGEGSYVACTTEKIFEQKQDLYDVYVDNQNVKTHREHLQPLLRVNSADKEKYQRLNDQRQLLMYSQEVDGDCGSCEEDLFILFFMEQNNRIFQTLLEVASSQDKTLTAEHARSMGLDPHGDRTFLMDLLEVYGFDLMLVIDNPCCP
The following text describes a protein:
Function:
Controls the rotational direction of flagella during chemotaxis.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MSEKNVETKGGSLKKIIIIVLVLVIVGAGAFGGYMLFAKNKKNANSANQMPVNNTNVINSQQTNDGMYPQQVVVSSKTYSLDEFLVNLADEDGKRFVKAKIFIGYEEKKLAKELEKKKPILRDAVIGVLRSKKAADINPKNIDKIKVEIINKISPMLEKGRISSIYFDDLIVQ
The following text describes a protein:
Function:
Myosin is a protein that binds to actin and has ATPase activity that is activated by actin.
Sequence:
MEPLPLENEDNQLNSNKSTTVSSKNFSNIFHNNIHNKDVVGLTDMCFLENVEENELMNNLQNRFNKDHIYTYIGEQVISVNPFSNKANIYTEQVLKSYQNMYMYEVSPHIYALAQDTYKKLLLSKESQCVIITGESGSGKTEASKIFLNYISKVCSGNLENIQGIMRLIIESNIVLESFGNAKTLRNDNSSRFGKFIEIEFDGKGSPISGKISQFLLEKSRVHSRAIGERSFHVFYQFLTDKRITSKLGLSNDPTQYKYLKDSMCFSISSINDSKDFQKVLESLKQLAWTEQEMESIWRVLGAILLIGNIEFSNDVEKSNVDAVYISTPETLKKVSQLLQCSEDSLEKSLISRSLTLGAGKRQSSIKVLLNQTQAKETRDAFSKVLYDRLFTSIIDKINSTISSKSNNGSNYIIESTIGILDIYGFEIFENNSFEQFIINYSNEKLQQLFINLVLRQEQEEYLKEGIEWKTIDNYFDNTPIIDLIEGQPVGLLKLLEEACLIGQSTPELLIQKFNQFFSKNKHFESFETSNNLSIESQSFTLKHYASPVTYNLDSFIYKNKDPLYQDLIFTMESSKDKFILSLFNKDFQKNSLGVKKIPITAATQFKNAINDLIGKLNTCQPHYIRCIKSNEDKRSNHFDYEAVRHQVRYLNMLETIRVRKAGYCHKQHYTRFLGRYKMISKETWPFWNGTPKDGVMAIVRAASAIQNSTSECQFGKKKLFIKSASTLFHFEELRQKILPSIVITIQRVWRGYKVRKWYKQELQRLREEKEEIQKQIKRKNSANLIQTYYLRYKVLTYIKKLKPWSVGPHYNKGHIMPTLWLRRTPIDSLMQSIHIIWWAKVKVTSLSMEARSLVRQKILALDLFGMGYSRKKEWDCRRKFQADYLSDDSNPKKSQFSESVQAMFQKGGDKEILFADNVIKINKRGKSQLRSLIITDQHIYKYDTKKYTQKKVGLKLHSIVALSTSNKKDTFLAIHFKQPIRDLYIDLGCDFVEKVSEVCTNLVQQVYKLTGTTIPLVFRDPLTFNNSRDSRNNGTDFVVSFSQYPKGKEQRQSTFVKGKGNTAIVYYNLD
The following text describes a protein:
Function:
Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Sequence:
MLLWRLGCRGPALGIVRGLKPVAPRFPPVREFRSRNPFTRGQEKDWRSRNKTVLTYVAATVVGMVGMSYAAVPLYRLYCQASGLGGTAVAGHSSEQIEAMEPVKGRVIKVTFNADVHASLHWNFRPQQSEIYLVPGETALAFYRARNSTENPVIGISTYNVVPYEAGQYFNKIQCFCFEEQRLNPHEEVDMPVFFFIDPEFAEDPRMARVDTITLSYTFFEAKEGQKLPLPGYS
The following text describes a protein:
Function:
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Sequence:
MMQGRDPKRKIFLIATEESGDRLGSALMKVLRQRLGDGVQFEGVGGRTMAREGLETLFPIEELSIVGFAAVVQQLPKILRLIRETADAVLEAVPDALVIIDSPDFTHRVARRVRARNPAIPIVDYVSPQLWAWRPGRARTMLGYVDHVLGLLPFEPEEYRKLGGPPCSYVGHPLIEQLGSLRPNAEEQKRRNSELPVLLVLPGSRRSEIRHHIEVFGAALGRLQAEGRAFELMLPTMPHLEATVREGIASWPVKPQIVIGEAEKRAAFRIAHAALAKSGTVTLELALSGIPMVTAYRVGAIEAFILRRAIRVSSVILANLVIGEDVIPEFLQEDCTPEKLAPALSEVLTDSDMRRRQVEAFARLDTIMSTGNKAPSVLAADIVLATMRKGRR