lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MASAGKEVKLIGSWPSPFSLRIELALKLKGISYDYIDEDLTNKSPLLLKSNPINKRIPVLLHNGNPIPESFIVLEYISETWPESPNLLPQNPYDKARVRFWVDYFEKKVTENCRAILATEDKEMERTVAMIRENLKVFEDGLLRDYGGENPFFNGENNPGLLGLVVGSFSTWYKVMGEIAGAKLIEEEKTPAFSSWLSAVCNVEVVREKQLEYGKVLAVAKRMRDINLAAKHGA
The following text describes a protein:
Function:
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA and has weak ATPase activity. The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA.
Subcellular Localization:
Nucleus.
Sequence:
MDQYPDENEEFELQYQDELELLEDLPDEFNAYDGPSTSKQAAEKQKENRAPVAALRDSTRLGNSTLGSPQLSQITFGASQLGGEEEAEGTSSGGQVNRRLFGTPKGPPVGRGCSTPFQRMPAIQELENTQLTSRSYGLEKENAAANQLQEVGLKNVNKRRLERDLFGDIDDLFHESYEDPMVKKARTEEQRDHEAIERILELRRKMRESSKTLRKDDVSRLKALHDFKMRNLSYEIPNWPFLAIQRSDLERIYVRFHSEDYEQRQLDLISARGEVVGSLLGEAKDKIWQEAGEIVLSRATAAEDADVTLVNSNANSEPGRLWVDKYKPRKYIDLLSDEMTNRSLLYWLKMWDKVVFGKAFHSKREQEAVTGEGGTAGGAANQLNSFNKRTGKFESNGGWRQRKSRQALNTNVDALGRPMQKVALLCGPPGLGKTTLAHTIARHAGYNVREINASDDRSPEAFKLALENGTQMSSVLNEDKRPNCIVLDEIDGAPRQSIDYLVKFISDAVYTKVKAKGAKAEHNVLKRPIICICNDVYDPALRPLRQVAFVVTFPPIDAARLAERLVKIAFKEQLKTDFGSLIALAEKSGNDVRSCISSMQFFNAQKHSLTLQDVLNNNLGQKDRHQGLFAVWDAIFRIQRPRKTLHTDANKVDEPAQVTMTNTSVTTRVRNVLEVVHSSGDYERLTQGVYENYLQQKMPDPNFTGVCEALKWFCFTDTVQHQISRQQNYSVYPYLQYGFVAWHLLFATLAWPKIAFPTRGFEFQQKSTNQRNIFQALCKGVTTSALGVGQGGTLLLDTVPLLKRILSPQLRSVAVQLLSPKEQQDLRHTIEVMVDLGLTFVQVKSQEGHYVFQTEPDLDALSAFPGYTGLSLPYFSRQLIAREVDLERIRRAAPKGGAPSAPAAKKKTSGAAAQLPNHLQTLKPKPISASNMHSAPKQQLTKDFFGRITHKSTSTNSAEESKTDAIVKSPIWYRYKEGFNNAVRKDVHIHELL
The following text describes a protein:
Function:
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSQVIQGAVEEPVYSNKSLTNENDSFLSLIESFSQERGVPIDINPKIGRKPILLYELYKKVIKRGGYDAVSATEDGWTNIAEEFNQSDPARSAGILQNVYFKYLISWEIHDHWHLLLPPPSTLELSENRQNVLERVKVFNSCSPPKPTNPITIIDNDKTHSFKKFYKSLVKEDEENGIEKKINEAMNSSASQPLPNSTNFASTTFPSVPFHPLPVDSGLQKYIDRNSNLTPPALGAGVPGPPLLVRVALALKSQQDKEVDWAIGHLIKISFERHQEFKLERLPSLAECLVYSLGFQVTKAKQVSDLTDISLCMDRAIGIALVLRNSVLSVENAKHVAQTKLVISVLEASIRCAKTFNNLEFLHYCLDISEMISSYLHVEDEKNVFYLALCEFLNSSDYSILIATLRTLARLALNDRNNRLLQDLKSNVIANIIALVETDNEEIVAAALDFLYQYTTYRTNTSNLLASQEAWMLVDQLIRLMMYQAQERFMTVTIENSESNPAVKHEATSSISLPMEELQQLVAMREPERSVKWMRCCFEPSSDDYVLQTDIWQLYCSDMERAQGPNVMGISPADFIKVSSHAFYNARAMTVSTPQLPVEYVINGIKRRKFPTSVNGMRYQPCRWCLDSGKECGELLLGTPLLHSHLQEMHIFPQILETGKCRWSDCKYEIQRLTPASELSHYQLLSHIVTHLHDDSLETLVEGRKLSPSREFRIPLLLTAVDDQGDATGIALTATLVLRNLVRSKQGKMLFSAIESRVLEVSSLNPAVAPYVSEMLLGQI
The following text describes a protein:
Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MADSSAAEPTTGASSPPVASDENSTQIQPIRMPTIEEIRAQEVWNNCAVRAVTSGVMGGGLGLMMGLFLGALDNPITHDTMTARQQFVFTAKQMGQRSWNSCKTFAVMGLVFSAAECIVEKARAKHDTVNTAIAGCVTGGSMSARGGPKAACIGCAGFATFSVLIEKFFDRHT
The following text describes a protein:
Function:
Accumulation defines the body wall muscle cell fate during embryogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MNQTETSTAPANAETYDTNIYYTPSPRVTANDITTLTTFATPVPQALDYVNTQYNDIYRNQPATYYLPTYGQPGSSSFYPDFSNFNVARTQDFAALPTVAADIKPIIIKQEKEVSSGGSNNNDPTSTDLLGDGVAHSGDETAPIATLVAGANAPRRTKLDRRKAATMRERRRLRKVNEAFEVVKQRTCPNPNQRLPKVEILRSAIDYINTLERMLTSVGKTTKIMDQNHHLQMTQPISAAPHDYITSSHFANAGYNPDGPNVYDDEDLSDTDEDRDHHHHKLGNAIDLRRRNSLDGLARIVDNIPLLQSQPEVPNEIPAGSEDKKLEIL
The following text describes a protein:
Function:
Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.
Sequence:
MESRPDGRQPLGDEAAAAAPGGGPDAGGGGGQEEEEKDGGGGGGGGGGAAAEEPRPPASAGPPQPARPRGSGSPKRGGPAEPGARPGGAVEARDGTAEPTVVPSGAGPAMAGPAVAKPTVAKAAAEEAAGSGAGEGSSSSLGPSPASLDSLDSFSNLHSCPSSSDLTSDDGAEAPRPDRTPADEGGGGPAAAAAAASWLASKERFPGQSLYHIKWIQWKEESTPIITQNENGPCPLLAILNVLLLAWKVKLPPMMEIITAEQLMEYLGDYILDAKPKDISEIQRLNYEQGSAHSRHSANTPDLFLDPSSVGKTAREIPECIDLPCLESQRIIPTHSVGEKNMSDAMAILHKLQTGLDVNVKFTGVRVFEYTPECIVFDLLAIPLYHGWLVDPQIADIVKAVGNCSYNQLVEKIISCKQSDNSELVSEGSAVPAGDRPGFPDGRENRVGEPAQRRRGRELLRFRIPPAASFRPGDGVPGTAGSDRSGLPNGPIPPTRAAESGAQLGADPRRNQRPGAGKETARGGGPPGLAVLPGAGTGAGPGGRDGPDAGPAGARGGLPGQQPGPRERRAQAEGAPGTRQGEGKGEEQLRHLVTRGGVVPGSGAGRSLARSTPSVPHHSADSVPAPKAGGIPAHGAPLPAPRGPPGAVEPRERRGGDGARSRSRGTPHSVASHANHEIP
The following text describes a protein:
Function:
Plays an essential role in chain termination during de novo fatty acid synthesis. Possesses high thioesterase activity for oleoyl-ACP versus other acyl-ACPs. Substrate preference is 18:1 > 18:0 > 16:1.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MLKLSCNVTDSKLQRSLLFFSHSYRSDPVNFIRRRIVSCSQTKKTGLVPLRAVVSADQGSVVQGLATLADQLRLGSLTEDGLSYKEKFVVRSYEVGSNKTATVETIANLLQEVGCNHAQSVGFSTDGFATTTTMRKLHLIWVTARMHIEIYKYPAWGDVVEIETWCQSEGRIGTRRDWILKDSVTGEVTGRATSKWVMMNQDTRRLQKVSDDVRDEYLVFCPQEPRLAFPEENNRSLKKIPKLEDPAQYSMIGLKPRRADLDMNQHVNNVTYIGWVLESIPQEIVDTHELQVITLDYRRECQQDDVVDSLTTTTSEIGGTNGSATSGTQGHNDSQFLHLLRLSGDGQEINRGTTLWRKKPSS
The following text describes a protein:
Function:
Together with WIT1, required for the nuclear envelope docking of RANGAP proteins in root tips. Plays a role in nuclear shape determination. As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MEEIIREDYFEALSSRNEEEQEMLRMLTKLEIDSAYTSEKLMNLHVLLMHLLAWDNDLEGMGTLDSSPASFEKALTFDLLCGILESEVKEVDEVLDVLEAQIVDTSYKISSCKHGNYIVIEGKLGESAESLKQSRGQVSEITLQLAQLRRTLHYIRNGTSENEESVELRQKYALKPSDLRHKNALRMLEKSLSRELELEKKLMEFQQNEEQLKLKLHYTEEVSSRMEEASEFIWGRFLEADNSSEVLTGISKELVGRLQILQFSLNGSAQRESELKSKLEDCTVQLEAKDLLVQKLEGTISENSEIVSEVLTLREYVKSAEQKLKNTDLELKSVNASKQEILVHLAEMENANESVKENLFEAESRAESGEAKIKELDAANLELTEELNFLKDADDKKTKKVNSLEKQVRELEVQVQNSKVSSEANQEQQNMLYSAIWDMETLIEDLKSKASKAESRTETVEEQCIVLSTTNSELNKDVSFLRQKAKSLEAMLDLANNEKERYAQEITTRNKVLMDMMLQLSSERERIQEQLYSLAKENKILRVNQCSNTYQRNGSYAGDKELSFHADGHEIEALAESLQEDERTREEPEKQSVSEKSSEIRRAIKLKHILVVALVFVLFCSFFGVTY
The following text describes a protein:
Function:
May be involved in extracellular digestion.
Subcellular Localization:
Secreted.
Sequence:
MEKSLITVGLLLLIGAGVYLNQNGEELGELQKVRQFNDWKIQYNKKFSSEKEEMYRYLVFQQNAQLIEAHNNDKSGKYTYTMETNQFADLTEQEFAQKYLTFRPKSTNKSKSTDYVPNGQARDWVEEGKVPPIKDQGSSCGSSWAFSAVGVLEINSNIEFGLETTLSEQDMLDCSGPYGNQGCSGGWMDSGFEYVRDHGIANGSVYPYVGSDQTCRTSVKRDFKYVTGFVDVDGCNGLQTAIQDQALSIGVDASNWAYYKGGIFNNCKQNLTSGSILVGVDQNGVWKVRHQWGSKWGENGYIRLAPGNTCGVCLSASYPVLEKK
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.
Sequence:
MPKAPKGKSAGREKKVIHPYSRKAAQITREAHKQEKKEKLKNEKALRLNLVGEKLQWFQNHLDPQKKRYSKKDACELIERYLNRFSSELEQIELHNSIRDRQGRRHCSRETVIKQTMERERQQFEGYGLEIPDILNASNLKTFR
The following text describes a protein:
Function:
Positive regulatory protein for the ethanol regulon, alcA and aldA. It control positively its own expression and possibly in a negative fashion the expression of the gene coding for ADH-II.
Subcellular Localization:
Nucleus.
Sequence:
MADTRRRQNHSCDPCRKGKRRCDAPENRNEANENGWVSCSNCKRWNKDCTFNWLSSQRSKAKGAAPRARTKKARTATTTSEPSTSAATIPTPESDNHDAPPVINSHDALPSWTQGLLSHPGDLFDFSHSAIPANAEDAANVQSDAPFPWDLAIPGDFSMGQQLEKPLSPLSFQAVLLPPHSPNTDDLIRELEEQTTDPDSVTDTNSVQQVAQDGSLWSDRQSPLLPENSLCMASDSTARRYARSTMTKNLMRIYHDSMENALSCWLTEHNCPYSDQISYLPPKQRAEWGPNWSNRMCIRVCRLDRVSTSLRGRALSAEEDKAAARALHLAIVAFASQWTQHAQRGAGLNVPADIAADERSIRRNAWNEARHALQHTTGIPSFRVIFANIIFSLTQSVLDDDEQHGMGARLDKLLENDGAPVFLETANRQLYTFRHKFARMQRRGKAFNRLPGGSVASTFAGIFETPTPSSESPQLDPVVASEEHRSTLSLMFWLGIMFDTLSAAMYQRPLVVSDEDSQISSASPPRRGAETPINLDCWEPPRQVPSNQEKSDVWGDLFLRTSDSLPDHESHTQISQPAARWPCTYEQAAAALSSATPVKVLLYRRVTQLQTLLYRGASPARLEAAIQRTLYVYNHWTAKYQPFMQDCVANHELLPSRIQSWYVILDGHWHLAAMLLADVLESIDRDSYSDINHIDLVTKLRLDNALAVSALARSSLRGQELDPGKASPMYRHFHDSLTEVAFLVEPWTVVLIHSFAKAAYILLDCLDLDGQGNALAGYLQLRQNCNYCIRALQFLGRKSDMAALVAKDLERGLNGKVDSFL
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Sequence:
MQLLLALLSLTALITSSYCVRIPLFATLRHLQHEIDNLKAEVVVLRQTQDQCHPTEAPPTDVGKNKDAAVTVNFASCRLTKSENGEVVGRVDLREQSDTNVLQLRLQVDGAKLTLAANSKHGFHVHTYGNISGSCSTTGGHYNPDGVDHASPTSAQRHVGDLGNVQADASGNIDVSFNDTYASLTGTKAIMGRAFVLHGGEDDIGLGGNAGSLASGNAGPRLACCVIGWATGTDWVY
The following text describes a protein:
Function:
Serine protease that promotes tuberculosis (TB) pathogenesis by promoting the processing and the extracellular release of the M.tuberculosis (Mtb) heat-shock protein GroEL2. Hip1-dependent cleavage of multimeric GroEL2 results in release of cleaved monomeric GroEL2 into the extracellular milieu. Conversion of multimeric GroEL2 into monomeric GroEL2 is likely to be a mechanism for regulating GroEL2 functions during Mtb pathogenesis. In vitro, exhibits proteolytic activity against synthetic peptides and the general protease substrate azocasein, and exhibits esterase activity against the ester substrate p-nitrophenylbutyrate; Key immunomodulatory virulence factor, which promotes survival in host macrophages and modulates host immune responses. Impacts host innate immune responses by preventing robust macrophage activation. Dampens macrophage pro-inflammatory responses by limiting toll-like receptor 2 (TLR2) activation. It also dampens TLR2-independent activation of the inflammasome and limits secretion of interleukin-18 (IL-18). May act by masking cell surface interactions between TLR2 agonists on Mtb and TLR2 on macrophages. In addition, impacts host adaptive immune responses. It prevents robust maturation of infected dendritic cells (DCs), limits the secretion of key pro-inflammatory cytokines such as IL-12, impairs Ag presentation, and modulates the nature of Ag-specific T-cell responses.
Miscellaneous:
MISCELLANEOUS: Hip1 is an attractive target for developing immunomodulatory therapeutics against Mtb.
Subcellular Localization:
Cell envelope. Cell membrane; Lipid-anchor.
Domain:
The active site region is accessed through a large opening that suggests that the enzyme has endopeptidase activity rather than exopeptidase activity.
Sequence:
MGMRLSRRDKIARMLLIWAALAAVALVLVGCIRVVGGRARMAEPKLGQPVEWTPCRSSNPQVKIPGGALCGKLAVPVDYDRPDGDVAALALIRFPATGDKIGSLVINPGGPGESGIEAALGVFQTLPKRVHERFDLVGFDPRGVASSRPAIWCNSDADNDRLRAEPQVDYSREGVAHIENETKQFVGRCVDKMGKNFLAHVGTVNVAKDLDAIRAALGDDKLTYLGYSYGTRIGSAYAEEFPQRVRAMILDGAVDPNADPIEAELRQAKGFQDAFNNYAADCAKNAGCPLGADPAKAVEVYHSLVDPLVDPDNPRISRPARTKDPRGLSYSDAIVGTIMALYSPNLWQHLTDGLSELVDNRGDTLLALADMYMRRDSHGRYNNSGDARVAINCVDQPPVTDRDKVIDEDRRAREIAPFMSYGKFTGDAPLGTCAFWPVPPTSQPHAVSAPGLVPTVVVSTTHDPATPYKAGVDLANQLRGSLLTFDGTQHTVVFQGDSCIDEYVTAYLIGGTTPPSGAKC
The following text describes a protein:
Function:
Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation. Extrasynaptic beta-2 receptors contribute to the tonic GABAergic inhibition (By similarity). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity).
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle.
Domain:
The extracellular domain contributes to synaptic contact formation; GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.
Sequence:
MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAANANNEKMRLDVNKMFYKDIKQNGTQYRSLWDPTGDLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
The following text describes a protein:
Function:
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
Sequence:
MSNDLGIIGLGVMGANLALNIAEKGFKVAVFNRTYAKTTSFLKEHESEKFAANLNGYETMKEFAASLKKPRRAFILVQAGAATDSTIEQLKEVFENGDIIIDTGNANFKDQDKRAAQLESQGLRFLGMGISGGEEGARKGPAFFPGGTPSVWEEVRPIVEAAAAKAEDGRPCVTFNGKGGAGSCVKMYHNAGEYAVLQIWGEAYSALLAFGFDNDQIADVFESWKADGFLKSYMLDISIAACRAREATGNYLSEKVKDRIGSKGTGLWSAQEALEIGVPAPSLNMAVISRQMTMYKGERIANCKAFPNFPRGPSEEATDKSPNSPEAKKLYHAVSLCIIASYAQMFQCLRELDKVYGFGLNLPATIATFRAGCILQGYLLGPMTKAFEENPNLPNLMDAFTKEIAAGLDDCRQILAKLTVNTAVSLPVMMASLSYINAMYTETLPYGQLVSLQRDVFGRHGYERTDKDGRESFEWPALQ
The following text describes a protein:
Function:
Transcription factor acting in the phytochrome signaling pathway. Activates transcription by binding to the G box (5'-CACGTG-3'), particularly in the dark but barely in far-red light. Acts as a negative regulator of phytochrome B signaling. Represses chlorophyll biosynthesis and photosynthesis in the dark. Recruits the histone deacetylase HDA15 to the promoters of chlorophyll biosynthetic and photosynthetic genes. HDA15 represses their transcription by histone deacetylation. Promotes the expression of MDP60 to modulate hypocotyl cell elongation in response to light and ethylene signaling. Required for submergence-induced and ethylene-dependent underwater hypocotyl elongation.
Subcellular Localization:
Nucleus.
Sequence:
MPLFELFRLTKAKLESAQDRNPSPPVDEVVELVWENGQISTQSQSSRSRNIPPPQANSSRAREIGNGSKTTMVDEIPMSVPSLMTGLSQDDDFVPWLNHHPSLDGYCSDFLRDVSSPVTVNEQESDMAVNQTAFPLFQRRKDGNESAPAASSSQYNGFQSHSLYGSDRARDLPSQQTNPDRFTQTQEPLITSNKPSLVNFSHFLRPATFAKTTNNNLHDTKEKSPQSPPNVFQTRVLGAKDSEDKVLNESVASATPKDNQKACLISEDSCRKDQESEKAVVCSSVGSGNSLDGPSESPSLSLKRKHSNIQDIDCHSEDVEEESGDGRKEAGPSRTGLGSKRSRSAEVHNLSERRRRDRINEKMRALQELIPNCNKVDKASMLDEAIEYLKSLQLQVQIMSMASGYYLPPAVMFPPGMGHYPAAAAAMAMGMGMPYAMGLPDLSRGGSSVNHGPQFQVSGMQQQPVAMGIPRVSGGGIFAGSSTIGNGSTRDLSGSKDQTTTNNNSNLKPIKRKQGSSDQFCGSS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSNLSLEETATMAYRNDDFLQMNLLTIGNLFNSYFNNSPFYDPTCLNEQVNRYEKFTDIFDENGITYRLTYVQIQEPNFLKTLDPANPPKELILETEQEIYAPEKANYPITTGLCVISKYRTRLQDHGEPIKELLAQYYMIDATIYQAPDLYSLVTSNFRTAIFNLREAIRDADSAYKWTPEMRYQKANVNIPTKPPFLFGAYEMENIIAEHSIEKDLQKYFIGQVIAQLPQ
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLENYQNLVWLGLSISKSVISLLEKRKLPWIMAKEEIRGPLPGYFKVSEMTISQEPKAKTRTLFGKDVPGAEIKELSAKRAINEVLSQFDTVIKCTRNVCKECGNLYCHNMQLTLHKRNHTQKKCNQCLDCGKYFTRQSTLIQHQRIHTGERPYKCNECIKTFNQRAHLT
The following text describes a protein:
Function:
Ligand and pH-gated channel that mediates chloride transport in the mid-gut and thereby may function in larval metabolism and fluid homeostasis. Channel opening is triggered by zinc binding or, to a lesser extent, an increase in extracellular pH.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHSPGAAAYVFLQCLVALVAAVIAQSGADQPPTTVVEVTAHGSVSMTPPTPRSPLLNETELVELNQPGSTAVFVALPTNPPTVSVDSSSTTTVASTQEPTSTTERTMSPEEIQKLLLPPATVEADILHVNATDDNRPDAKSSGKDSECPTLEGADHLSQTQLLTRLTHVCRYDRLERPKRESINGTNGPVKVYARAYIYFMQNLEAHDLQFKIHALLQFRYVDPRLVFREVAPNRTKPIMGEQSLRDLLWVPHVFLANERSSDILGTAEKDILTSISPDGTVIVSTRISATLYCWMNLQKFPFDEQHCSTVLESWMYNEDDLVLLWEHKSPVTLAPELHLTEYVLLEMFTNETVINADLSDLRHGAFAGNYSSLSFTVHLAREMGFYMMDYFIPSIMLVAISWVTFWLQADQSAPRITLGTSTMLTFITLASAQGKTLPKVSYIKASEIWFLGCTGFIFGSLVEFAFVNTIWRRKRNVEVKKVNSKHVLKQAITPRPARKDMSGLHKSHSCTSLADSATTVSANSFNNYLTVHSIPQKSPSSATLPIISTTDVDRAMTEASNVTIQIEGQTSNVNGNGWTTMTPQEVAIWIDKRSRFVFPIAFVIFNIFYWTFVYYV
The following text describes a protein:
Function:
Catalyzes the transfer of L-noviose from dTDP-4-O-demethyl-beta-L-noviose to the phenolic oxygen of novobiocic acid, creating the full ABC ring system in the novobiocin biosynthesis pathway. Novobiocin is an aminocoumarin family antibiotic that targets bacterial DNA gyrases. Also shows activity with variant coumarin aglycones, suggesting it may be a promiscuous catalyst for noviosylation of a range of planar scaffolds. Does not show activity with TDP-L-rhamnose.
Sequence:
MRVLLTSLPGIGHLFPMVPLGWALQAAGHTVLVATDREFLPVVTGAGLSATAVLDPVDPVELFKPVEPFGDPLSPAERTGHRCAEAGVRALPAMRALVDVWHPDLVIAEPMELAGPAAATNAGVPWVRHSYGLIPPGPLLSVAAEVLDAELAVLGLSALAKPARTIDVCPDSLRPSDGVATVPMRYVPYNGPAGVPDWLLAGPPARPRVCLTLGTSLPRRDPHVAPLWRLLLDELVALGQEVVIAIDESHRPLLGHLPDGVRAARIPLCDLLPTCTAIVHHGGSGSTMAAASFGVPQLVVPHFADHFTNAERLTAVGAGLSLPHDTDDLARISAACELITGDGPHRAISRRLADENARRPTPAVVAEGLAAEQRSMTPA
The following text describes a protein:
Function:
Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP.
Subcellular Localization:
Nucleus.
Sequence:
MDDDQYDEFGNPLHGDAYESSGDETGETGAQLVRRESADEHGEAARDLVLQRAEESVYGPDVELLVELEDREGLGVPLVKAESERRRVETAVFTQRDRNVPRARYDREYMMQLACAPERCRAACVVGALHSGKTSLLDLLAVQAHERLPYMSKAMRQGWKPLKYTDSLKIEIERGVSMKLNGFTFLGADGRGQSHVLTLIDTPGHVNFMDETAVAMRACDVCIVVVDVVEGLSSVVESLIKRAERLGLPLIFVLNKIDRLLLELKLPVKDCSLKLHALVDKINAYTQGRYSPERGNVLFASSKLGFTFTLEEFVKYYYAPKLQAGSSELVERLWGRVYFHKGQFSLHPNPENEVTFVQFVLKPLYKIITHTLSKDPSDIERLLHQELGISLGDIPPDVDQVPLLKMVMGRVFGDETGLIDAIVKHGQPSTYKSQKELPVNADGTVAHVLKLMEYGGELWSLVRIYSGELRAKDFVSVINESQDVSAIEEDEITKVQVGQVALLGGRYILPVTHASAGQLVLVKGLDEYYTKSATIFTGPAVCFPLIDYYNEPVFKVVVQPQVPSELPKLLDGLNLVHKLYPGAVIKVEETGEQVIFGSGELYLDTLLYDLRQNCAKIEIKVSMPLVKFSEGCSDTSFAAIPVSSPDGKIKLVISAEPLQQELIRDLTRGKLVSSELQDMKTLARKLRNDYGWDSLAARSVRSFHNCNVFLDDTLPDEVDKGLVNAVMRHILQGFKWALREGPLAEEPIYGVQFKLLDLQIEGDHSSSSIQLVALVRRACYIALLTAVPVILEPIYEVDIVVHEVLASIVKNLFAKRRSARIYKIEAIVGTPLIEVKGQMPVIESVGFETDLRLATSGGAMCQMHFWNKIWHKVPGDVMDEEAVIPKLKPAPMDSLSRDFVMKTRRRKGLSSEGYQSNNGPTLEKYIEPELYAKLRERGLV
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MHMETFVMIIIKRLKDANLFLSYLVSLNNVRRYKSHLSWPPIFASGSWDESVSLRWVDLGLSVSHIFRPVPRCCTMKRTARPTENTCPEELAESSEEVKTDTDRNVLVMFDILRVEITVDDSRHIVRPRNAPAASAIASGEVSYSHFVFRFDFKDWKLMKEVVTEGEELLPHRTSQSNLCNEENDQINLEARAQITPIRKLTRNRGLVLQDHVVEETPEENQAFKRRRLFRNQD
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPQNFYIEEAIKKHGRRLDHEERKRKREAREVHKTSAKAQKLHGFKAKLYNKKRHSEKIQMKKTIKMHEERNNKHKTNDQPVQEGAVPTYLLDRENQTRAKVLSNMIKQKRKEKAGKWQVPLPKVKGMDEAEVFKVVRSGKRKIKQWKRIVTKATFVGEGFTRKPPKYERFIRPMALRYKKAHVTHPELGATFCLPILGVKKNPSSPMYTQLGVMTKGTVIEVNVSELGLVTQTGKVVWGKYAQITNNPENDGCINAVLLV
The following text describes a protein:
Function:
Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule. PA is required for plant development and responses to abiotic stress and pathogen attack.
Sequence:
MAKPSSEGDSSTASRTGSRSTMGESSLKGCGFSSFTGFRAEKEDVLRLAMPLYLRLAMLDCIKKKDVDAGDQHFQTSSSEDDPCENPVVVFINPKSGGRNGSVLQDRLQHIISQEQVFDLHNVKPDEFVRYGLGCLEKRAEKDNCAKETRKNIRVVVAGGDGTVGWVLGCLGVLHEKDQFPVPPVAIIPLGTGNDLARSFGWGGSFPFSRRSAIKRALQRATNGRICHLDSWHVVVQMPGGEVVDPPHSLKTTEVCDVDQNLKIEGRVPDKVNCYEGVFYNYFSIGMDAQVAYGFHHLRNEKPYLAQGPISNKIIYSGYSCSQGWFLTPCMSDPSLRGLNNILSIHIKRKNSSKWEPIEIPRSVRAIVALNLHSYGSGRNPWGNLKPDYLQKRGFVEAHVDDGILEIFGLKQGWHASFVMVELISAKHIAQASSIRLELSGGDWRDAFLQMDGEPWKQPMSKEYSTIVEIKRVPFPSVMVNGE
The following text describes a protein:
Function:
Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
Sequence:
MTVHEFKVEMTCGGCASAVERVLGKLGDKVEKVNINLEDRTVSVTSNLSSDELMEQLRKTGKSTTYVGVKKXDEFLSKFQKYGRLKLEV
The following text describes a protein:
Function:
Putative oxidoreductase.
Sequence:
MATFQTILIIGATSGIGEELARQYHSSGKKVIISGRRTERLEALTAELPGLGSIQMDVKNLAALPSKMDQAFAKYPDIDAVIINAGIQRLLDFNTTDVSAAQYPTTDAITDEVTTNLTGPTVLARCIIEHFKASRPNQPCLLALVTSGLALVPATMFPVYCATKSALHSFTALLRNQLKHTSISVVEIVPPYVETELDKDHVDEVARRMGGTRPQAMPVKQYVDQVMRGLEVTDANGKIQKYVADGLPRAAVDAWVTALSPMAKLLHTEL
The following text describes a protein:
Function:
Na(+)/H(+) antiporter that promotes normal di- or tripeptide transporter function, recovery following the peptide-induced acidification of the intestinal cytoplasm and maintenance of the peptide-dependent intestinal pH homeostasis. Regulator of free fatty acid uptake from the diet together with the dipeptide transporter pept-1. May play a timekeeper role in defecation cycle but is not necessary for pbo-4-dependent proton release. May play a role in the regulation of lifespan independent of the stress response pathway.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein; Lumenal side. Note=Colocalizes with pept-1 along the apical membrane of the intestinal cells.
Sequence:
MSLLRRPWVLVVGLLLIMSYVGAECEEEEKEYPSRYPIAYFEWENVKIPMTICLWLIGASIAKIIFNLIPHLNELFPDSALLIMIGLIIGIIFKLIGVNKNAFFLESEVFMLYLLPPLVFDAGYFMPARQFFDNFGSILCFAMIGTSFNIVAIALSLWAISLTGLFSVETPLMHMLLFGSVAADVDPVAVIVIFEELKVNEVLFIAVFGESLLNDGVAVVLYRMFLTFSEIGTENLITSDYINGGVSFLVVAFGGIGIGLLFAFLTSLVTRFARDEEVKVLNSVFILILPYTCYLCGELFGLSSIMAIVFCGAAMRQYCRENVDPDTVKATESFIKVLSLASETVIFVFLGLSTVSSNHHWDTSFIVLTVVFCLIYRTLGVVVMCYFLNKYRLNKYTKVDQFIMAYGGLRGAIAYGLVVAIPDFIPGKNMFVTSCIIVIYFTVFLQGITLKPIAEFLQVEKKNVHSKNMIEHIYSELIDTTMAGMEDIAGFKGHHWIRDSWNALNNNYLRPILVNKNNMKEMDKTKLVRKYKHLVDEDAKKIARGDLNSNMVFTKALIEHTRSRTNTMIDGVSSTSKIDFTKHMKENFGVTVYDDHSTVPMTPTHLFQETTEVEYSVRSEINDNDGFENDGYESDESGSFHERV
The following text describes a protein:
Function:
May be a modulator of IL-2 signaling.
Sequence:
MQSPAVLVTSRQVQNAHTGLDLTVPQHQEVRGKMMSGHVEYQILVVTRLAVFKSAKHRPEDVVQFLVSKKYSEIEEFYQKLYSRYPEASLPPLPRKVLFVGESDIRERRAMFDEILRCVSKDAQLAGSPELLEFLGTQGTRSPGATGFATRDPSVLDETASRPGDSDEAFDFFEQQDEVQPPTLGLSNKNVEKSLEEEEEEEEILDPLGIMRSKKPKKHQEVAMRTKPSPRLTIFDEEVDPDEGLFSSDKKVSPRRPLGTTEDPLKLFDDPDLGGAVSLGDPLLLPAAHESRGPTSSPEHRDASKELFRVEEDLDQILNLGSEPKPKPQLKPKPLVPSKPALPRKPTVPPAVGPSGTGAGPQKQQQIQAMDEMDILQYIRDQDTLAQDSPSLF