lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Subcellular Localization:
Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
Sequence:
MKPFNFQWQRVADIKMYLDGGQRSEAVTCCCTRVFLNDFWQYKLGLEGKAESYSESEGENVSQQDTTGSENYCEEESEEFSDICHGSKDGHEGDVATIPSCEVYQSRCCTDPSRKGLMNGIESSQDSNVEDADSLRSSSDHTGTYDTQDTRQKNLRGTLFIQSEPKEDDVAASSEECVCEAYEDIGESEKQAGADVDEEMAMMLAMGLPTSFLGDRTSAQKTRNSQHYGNRSRQKSRSSRSKKNHAYHNSQQYSDADCPAEVENIYNGEFQGPGEELLTSQQLTDREDSSADLQQQWEDYWTSYGEYLVWQSWSERYPEYTGNHGDNGHPGSTGETSTSSCQATETAGGATELIERSDTDYSQLDSQITSSQEHCNSHHSASMVPTERCQSEAESNIDMLLPHQESMDLHVPTNPAPVGEAETMEAGVGEDQKLWEQHWWEVYYQIYQQFVYWRGKEQPADWWDQTGEERLVQSEESNPGPECQVSTLGKITTDQSCFISKSHSLDQKGVNVSSCEETRTAQSNSMLDIPHHLQKQVASHSENCIEKGSEKSDHWKTIKEPVTTYLSEDAEPSDGQTGEKRKQQSTKTGPDSDGQSTSKPGTTVILGAPGGSRHGNTDGDEDPPEERPIKMKRSHELDEEETPAAEAEETSKQKVVEETELTSDPTKQDQASSDPAAKMESTFGVIGLKFARPPATRFKDLPRFSHSHVNFHQRKVGKRSKMLNIHTQSRTHIRFDEAGEVSCHETSPVVGRVRDFLQAVANEETGTEDSSQDLDSQPSTSQAEDNEARKPFLAEKESRHLTSEEDSSSSDSSDSESEDSISKETTLAPVQTKKDESETEETGSESDSSDNVTLSCKITNARQTDTEVTGDRQTDDTPCIRDSPTLPSPKAPVVDTTGINTSPLKKRRKKRRRRPMTPPLPMPPDVKDDPEIMKYWAQRYRLFSRFDHGIKMDREGWFSVTPEKIAHHIAERCRCDLIIDAFCGVGGNAIQFAFTCERVIAIDIDPVKLECARHNAAIYGVADRIEFLQGDYLHLAEGLKADVVFLSPPWGGPDYLTADVFDIKTMIVPDGYEIFEKTKQITDNIAYFVPRNADVEQLVSLAGPGGKVEVEQNFLNRKLKTVTAYYGELVDE
The following text describes a protein:
Function:
Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth (By similarity). Binds to double-stranded DNA and RNA (By similarity). Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA (By similarity). Also binds to single-stranded poly(G) RNA (By similarity). Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA.
Subcellular Localization:
[Isoform 2]: Cytoplasm, cytoskeleton. Note=Microtubule-associated that localizes to the manchette in developing spermatids.
Sequence:
MRSIRSFANDDRHVMVKHSTIYPSPEELEAVQNMVSTVECALKHVSDWLDETNKGTKPEGETEVKKDEAVENYSKDQGGRTLCGVMRIGLVAKGLLIKDDMDLELVLMCKDKPTETLLNTVKDNLPIQIQKLTEEKYQVEQCINEASIIIRNTKEPTLTLKVILTSPLIRDELEKKDGENVMMKDPPDLLDRQKCLNALASLRHAKWFQARANGLKSCVIVLRILRDLCNRVPTWAPLKGWPLELICEKSIGTCNRPLGAGEALRRVMECLASGILLPGGPGLHDPCERDPTDALSYMTTQQKEDITHSAQHALRLSAFGQIYKVLEMDPLPSSKPFQKYSWSVTDKEGAGSSALKRPFEDGLGDDKDPNKKMKRNLRKILDSKAIDLMNALMRLNQIRPGLQYKLLSQSGPVHAPVFTMSVDVDGTTYEASGPSKKTAKLHVAVKVLQAMGYPTGFDADIECISSDEKSDNESKNDTVSSNSSNNTGNSTTETSSTLEVRTQGPILTASGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFRGAGPNKKVAKASAALAALEKLFSGPNAANNKKKKIIPQAKGVVNTAVSAAVQAVRGRGRGTLTRGAFVGATAAPGYIAPGYGTPYGYSTAAPAYGLPKRMVLLPVMKFPTYPVPHYSFF
The following text describes a protein:
Function:
Transcriptional regulator required for the maintenance of the plant vegetative phase. In association with CHR11 or CHR17 may prevent the early activation of the vegetative-to-reproductive transition by regulating key genes that contribute to flower timing, such as FT, SEP1, SEP3, AGL8/FUL, SOC1 and FLC.
Subcellular Localization:
Nucleus.
Sequence:
MEMGSDGEDQKIRSVVGDANLNNKKKKIDNNSSSKDGRVKPKRQMKTPFQLETLEKVYSEEKYPSEATRAELSEKLDLSDRQLQMWFCHRRLKDKKDGQSNKPVKSSVAAVQSASVNELPAAAGSVPEQDSRSDSGSESGCSPYSNSRRNFASGSSSSRAELDEYETMGKPSYESRLSTMVHRAIVCIEAQLGEPLRDDGPILGMEFDPLPPGAFGTPIAMQKHLLHPYESDLYERHDPRPRRSHAAARSFHEQQSLDDPSSFTPNMYERYSENHARGMDYEVARSRISSFMHANGPVPRSYVTPGHASRNCSTSQQDMPSPIESAHHGDRFLLEKDSSVLGTEDPYLLPDGVRKSSDVHRKGKINDGRLGRGSETRENHGPKDLEKLEIQRKKNEERMRKEMERNERERRKEEERLMRERIKEEERLQREQRREVERREKFLQRENERAEKKKQKDEIRREKDAIRRKLAIEKATARRIAKESMDLIEDEQLELMELAAISKGLPSVLQLDHDTLQNLEVYRDSLSTFPPKSLQLKMPFAISPWKDSDETVGNLLMVWRFLISFSDVLDLWPFTLDEFIQAFHDYDSRLLGEIHVTLLRSIIRDVEDVARTPFSGIGNNQYTTANPEGGHPQIVEGAYAWGFDIRSWKKHLNPLTWPEILRQLALSAGFGPKLKKKHSRLTNTGDKDEAKGCEDVISTIRNGTAAESAFASMREKGLLAPRKSRHRLTPGTVKFAAFHVLSLEGSKGLTVLELADKIQKSGLRDLTTSKTPEASISVALTRDVKLFERIAPSTYCVRAPYVKDPKDGEAILADARKKIRAFENGFTGPEDVNDLERDEDFEIDIDEDPEVDDLATLASASKSAVLGEANVLSGKGVDTMFCDVKADVKSELEKEFSSPPPSTMKSIVPQHSERHKNTVVGGVDAVIDESNQGQSWIQGLTEGDYCHLSVEERLNALVALVGIANEGNSIRTGLEDRMEAANALKKQMWAEAQLDNSCMRDVLKLDLQNLASSKTESTIGLPIIQSSTRERDSFDRDPSQLLDETKPLEDLSNDLHKSSAERALINQDANISQENYASKRSRSQLKSYIGHKAEEVYPYRSLPLGQDRRHNRYWHFAVSVSKSDPCSRLLFVELHDGKWLLIDSEEAFDILVASLDMRGIRESHLRIMLQKIEGSFKENACKDIKLARNPFLTEKSVVNHSPTDSVSPSSSAISGSNSDSMETSTSIRVDLGRNDTENKNLSKRFHDFQRWMWTETYSSLPSCARKYGKKRSELLATCDACVASYLSEYTFCSSCHQRLDVVDSSEILDSGLAVSPLPFGVRLLKPLLVFLEASVPDEALESFWTEDQRKKWGFRLNTSSSPGELLQVLTSLESAIKKESLSSNFMSAKELLGAANAEADDQGSVDVLPWIPKTVSAVALRLSELDASIIYVKPEKPEVIPEDENEQISLFPRDSPFKGKGPREQEDQDEVAPNPGNRNKKRARVSLGSGSNRKVKRKKAQSGLNKFVVGRRNVAVNSNLMAVELNHQVPGKGKRTVRKRPERIDEDNSHLVNRMANIVRPKSEEVEEDEEEEEQTFRDINEDWAAGETPREMEEDWANETPNRMMTPMQVDDESDNSVGVESEDEDGGGQFVDYSQRNKWGLDWNSNLNVAIEEDEEEEVVGVGRVEGEDDAEMSESSEDDDVPANNAANNYDRESEGYSSSDS
The following text describes a protein:
Function:
Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (By similarity). The condensin-2 complex plays a role in DNA damage repair or in protecting the genome from certain genotoxic stressors (e.g. boron excess, zeocin and aphidicolin).
Subcellular Localization:
Nucleus, nucleolus. Chromosome. Note=Localized at mitotic chromosomes from pro-metaphase to telophase. During interphase, mainly found in nucleolus.
Sequence:
MTSHGGGEVRGERIHTVQPERDLVANWEVDLSEKLEEYLLKICSGEITGNEEDGQIPVNFAEAALLLQGSVQVYSKKVEYLYNLVLRTLEFLSKQRDQEQSKGTSNENEASSSRQVDEEENDLFWNVDDIPVDTKNRLDSSVGGDTCPSQFVKPPANLVVLEGDCLDTSGDGGELESYLLATTHLYRDFILLDPCDAVAVNEFLGDNYGGKGRNSAHRGSSVRKSFHSSVGRSGGSARKSSVGKNQGTNVHLSPICGNGPNDQNCDQGSQPPVFEDNDHGFDMDNEYGGAMDFSDTDADEDDPWKPLNPYEPGKLKVKPFKKVKILKKIGWSITKDHMTSMFPLARPNGPISSELIEIWKMHGCASKDEQASQDIPYYEKLREMLVNGGNQPCGANGNYNDNDKDNHDEANNGDFHDFGEHDGDDAEHPFMDEDVLNMNDGGAAEFHNYDGFENGESNCQESLEDLCRSHLDALLANIAKSEKQTDLAARVSTWKQKIEQNLEEQELHPPFDIQEYGDRIINKLTVEESGNVETFTDLMKDQEKHEVARAFSALLQLVNNGDVDLEKPGNSTNEPMCYTAVKPFSVRLLKVHNRKNEKRGIHLPQKRAKSPITKGKSHESPPPKKRNTCSVSSQTRKVSLKISKINGVGVRCTPNSKKRRKGRSDDVTEVTEVASIEKSLGKL
The following text describes a protein:
Function:
Has an important role in DNA replication and in maintaining genome integrity during replication stress (By similarity). Promotes PCNA deubiquitination (By similarity). As component of the Elg1 RFC-like complex, regulates the functions of the DNA polymerase processivity factor PCNA by unloading it from DNA after replication during the S phase of the cell cycle. The PCNA-unloading might be regulated via interaction with the Enok acetyltransferase complex. Might have a role in restarting of stalled/regressed replication forks during replication stress (By similarity). In the ovaries, has a role in nurse cell endoreplication.
Subcellular Localization:
Nucleus.
Sequence:
MTDVNCLTSEHIAPTTTTASPPGTPSKNAATDPVEPTSPFVLRAPPSAKSKLILQNMEEVLNSVKQKHREKHKRKREEKRRAALMEDQKSTTEEVKANAKEKPQPLREKSSQENGLKNGRRRSSPLKSSTPVADNQSIMKHFAKAGKPENVGVSPVSTAKPKPTTNVFEFMMNARNRSLGVNEGGAESPADQEIGSEAATPTTKRKLLLQEWNERKGGAKRRLADEARGEFIELQMEQRAKRLRKMLTKTDAKEVTAPSSAPTDPTVKRLRGRPRSRRISSMDAQNQIVESKPPVVKAKDQDPGTEELLSKLSSPTKKRDSLLGYFPKVESPKELAEKVIIAIETPPMETPKRRTLRRKSQQETPIVAESTPSSRPRRSCVGKARYDYDLETSPGKQQKAKPQKADESVEIIDLDNSNPAATPKKLAPLFVRQLPKPSPDPSVLKARQAFLQSGVPDKIRQEQIRQKNFDQMYEDSYEVFPRLAHIGCESFGSKNGPLDIPFALRAEEEYSEVTKALPANKRRAKASSITSCLPADFTSSKTLNKFNYATLPQLENKRGFVKLWKNDFDRFPTFKCYNQMREKYRHFSAIDSAQDTQQMGESLVVTRRTRRSMEQNMAQNEEEAKPPPSAPNGELLFTEKYKPLLFEQVLVNLTPVQELREFLSSWSGNGGSNRNSQGMDDTFDMSNDSASMGSSSNTMVLVGPSSSGKTNAVFTLANDMNFNVLEINAGMKRTGKKLIQELQEATQSHQIRKDGKAGGGSSQQLLQKLQKSGLKAKAAAVEPPSEVRKSLILIEDADILFDNLDAGFTDAIYTLAASSKRPVIVVATDPNCAHLQRLMQQNIIHFQAPNALNISRFLAVLSLMENCPIELDELISVYLYNQQNLRKTLMELQFYIQSGGDSTRDRTGGGIKSPTKTSNSRLATVDGSRIHQRFFEFFTSPQNVQYRIPFPVDFSLLRLNLPDLMASSAMLKEQQAAGGGSRTAAKRKSRSPKKAWLSSATGQKSDGHSSSLATLASFYDNISVASLMDSDCSDRLQWHLSEEIGHLLVEQALQTGLATKECPYNLFDKPVQRFSICQHLGNGVLRSDSAKSLDFEPALRSICRSEKERAGLERKSSRFYHYLRNHTVNVTSFTTDYFDTACSTFQSAAPSSEPTMEAEPKD
The following text describes a protein:
Function:
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
Sequence:
MNVNVINHPLVRHKLTLMREADCSTYKFRTLATELARLMAYEASRDFEIEKYLIDGWCGQIEGDRIKGKTLTVVPILRAGLGMLDGVLDLIPTAKISVVGLQRDEETLKPISYFEKFVDSMDERPALIIDPMLATGGSMVATIDLLKAKGCKNIKALVLVAAPEGVKAVNDAHPDVTIYTAALDSHLNENGYIIPGLGDAGDKIFGTR
The following text describes a protein:
Function:
Involved in the biosynthesis of capreomycidine, an unusual amino acid used by non-ribosomal peptide synthases (NRPS) to make the tuberactinomycin class of peptide antibiotics such as viomycin and capreomycin. Catalyzes the stereospecific hydroxylation of the C3 of (2S)-arginine to generate (3S)-hydroxy-(2S)-arginine. Usually clavaminic acid synthase-like oxygenases catalyze the formation of threo diastereomers, however VioC produces the erythro diastereomer of beta-carbon-hydroxylated L-arginine. It exerts a broad substrate specificity by accepting the analogs L-homoarginine and L-canavanine for the beta-carbon hydroxylation.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MTESPTTHHGAAPPDSVATPVRPWSEFRLTPAEAAAAAALAARCAQRYDETDGPEFLLDAPVIAHELPRRLRTFMARARLDAWPHALVVRGNPVDDAALGSTPVHWRTARTPGSRPLSFLLMLYAGLLGDVFGWATQQDGRVVTDVLPIKGGEHTLVSSSSRQELGWHTEDAFSPYRADYVGLLSLRNPDGVATTLAGVPLDDLDERTLDVLFQERFLIRPDDSHLQVNNSTAQQGRVEFEGIAQAADRPEPVAILTGHRAAPHLRVDGDFSAPAEGDEEAAAALGTLRKLIDASLYELVLDQGDVAFIDNRRAVHGRRAFQPRYDGRDRWLKRINITRDLHRSRKAWAGDSRVLGQR
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSLIVTHPFTLVVTVAKIFGLLSAKTPSKTNWRLFLYSLVLVVLYVAILVLRFLGNQEKTEQSLSKVVTYLHVLCYVAVFSANICSNWFNSKSFIRGLIRLEFFDYQIKPAVEIDYNNMKKRFYASFGVFWVIFFVVATVDFVGEIVLAKLDLITWISFYFPFFYNSFGLFIIYSTLFLVSERFSCLEAILIKILREESLLDLKQFTLLFLELNEICNSMVANFSLQIATTFLMVFVIVTTNLYLMLKMHLNTIQFVLNVNFFLVHFGQIVLIIFVFYSVNKKIREIVSLSPRIFSVNGKTKTSLKEQIECYFLMKENRAHLSVLGMFHLDPSVLLSMGASIVSYLIILIQFTDNMPNLSKPRHDGGTGSMRSSVNR
The following text describes a protein:
Function:
Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.
Subcellular Localization:
Cytoplasm.
Sequence:
MNIAIIGGGLSGLSTSVHIRLLAQKQNKPLPNITLFEASDRLGGVIHTETLTDDHGRTFVIDHGADMFATAPSAAIDLCEQLGVADQLLRPSPLGRGAMIARGNRLIPIPEGFVLMRPTKLGSMLTTPLLSLTAKLRLLQERFIARRVESVTDESVGSFVRRRLGEECLDNIVAPLVAGIYTADVDRLSMAATMKPIWDMETSDGSLAKATLRRIRTGEDSTEQASSGARYEKFRAFPNGMKQWIDTLADFTGRENIRLNTAVQSIVPLPDNRYQLNVKSDIDGQSTQEFDQVVVSTPAHVAATLLQPLSEEAASTLRSIPFASTAIVVMAVRRECISRLPTTFGFVVPPKENRRVLAGSFASTKFPQRAPDDYVIVRAFVGGVMQPEILDSSDNEIIDIVRAELGELIGLDQTQSLQDITAMVKVVRWNDAMPQYEVGHLDKVQRIRTALASLEGLHLNTNALGGVGIAPVIAASKRTAERILK
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MMMDARLRRLVFLLLLAAAAPLATAQLSQDFYKTSCPDAEKIIFGVVEKRFKADPGTAAGLLRLVFHDCFANGCDASILIDPMSNQASEKEAGPNISVKGYDVIEEIKTELEKKCPGVVSCADIVSVSARDSVKLTGGPEYSVPLGRRDSLVSNREDADNLPGPDIAVPKLIDEFSKQGFNLEEMVAMLGGGHSIGICRCFFIETDAAPIDPGYKKKISDACDGKDSGSVDMDSTSPNTFDGSYFGLVLEKKMPLTIDRLMGMDSKTEPVVQAMADKKTDFVPIFAKAMEKLSNLKVITGKDGEIRKVCSEFNNPQNSSSSSSVIRTSSVNADEVAGLSSSSSRKVGPPDAVETPAMVADEAAAKVPGGVVVSVGGDQQQPPNPEADRPGLKLRGSREPVNPAAPVEPGPGGEDAAKQQAVAALEEKKKRNMAKLRAAQAKM
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MSLIHQTQPLNFASEDHHDEFSLFADALKTLRVDEIDPLDPEHGPAAVWKRICDSKLDNRNSHLSPEQKESWNLERNTWQLVQMLYTERTAPPQSSSSKLTSNPYLPPLKVVNLHLSKSKDLLELSTFRDWLYTCPSSTHPAEIRRGYWPYTKASLKHTLQKYPHSDSRRPSGKAPPFHAMDPDAPLRASRQQTNQRSQTLQSDDNLNFVSDPNAIQEKGDLEQLDQEYDRAMVKTLYEYIRAGEMGLALDFCRQCDHPWRAASLAGGQLFQDPSLEEFEDESPLPQDEVLPDAESLDNPLNETRNLPPYKRSGCLNRKLWKSMCLHMSSNKSLPTYEQALYGALAGETSSVLPVCYTWEDHIWCHINAIFENQVDQILESNQLGYYWSHGALPPAENHQIDASDDDTIISSLQPQHVARQNFPQRSNGEPQTDIKLAMNKAFDKILRSEQTSLAESARNPFHVAQMWLAIDKINDLFTSFSDRLKSASEDFTREHLSHLLRFFSHLILFLRAIDEKVDSEASNAILRGYVQVLEMENKHNLIAFYVAELQPESGVETYAKYLISLGPSADFPTRRVALLRALEHGLDISRVACTAVKLTLQEITRASLESNREHGLNKFSHQLTDKQRELIRSLEWLIIDPATYLEALIQANSLIRYFLTAGHPNAAREVVCSVPADVLSVIAQGKDPLAEPEAGDITGNTHNAILEFTQYRDFFNCLELHVQVDEILSQRPMDGSTTSELQAFTEALEEMCDHLYTAVTAILSSEWLQDIRFNPTENIDEQEQAADRRIAELNLIRNIYIPELVFRLHGALAESGDYIVTNLRRALDLATLVANESYKNYVEFMPLNQQELSTPAIHKKKENKMKDYLRELRVVHLRILKCSGVHPLRAVLK
The following text describes a protein:
Function:
Plays an essential role in the initiation and regulation of chromosomal replication. ATP-DnaA binds to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex once per cell cycle. Binds the DnaA box (a 9 base pair repeat at the origin) and separates the double-stranded (ds)DNA. Forms a right-handed helical filament on oriC DNA; dsDNA binds to the exterior of the filament while single-stranded (ss)DNA is stabiized in the filament's interior. The ATP-DnaA-oriC complex binds and stabilizes one strand of the AT-rich DNA unwinding element (DUE), permitting loading of DNA polymerase. After initiation quickly degrades to an ADP-DnaA complex that is not apt for DNA replication. Binds acidic phospholipids.
Subcellular Localization:
Cytoplasm.
Domain:
Domain I is involved in oligomerization and binding regulators, domain II is flexibile and of varying length in different bacteria, domain III forms the AAA+ region, while domain IV binds dsDNA.
Sequence:
MKEKQFWNRILEFAQERLTRSMYDFYAIQAELIKVEENVATIFLPRSEMEMVWEKQLKDIIVVAGFEIYDAEITPHYIFTKPQDTTSSQVEEATNLTLYDYSPKLVSIPYSDTGLKEKYTFDNFIQGDGNVWAVSAALAVSEDLALTYNPLFIYGGPGLGKTHLLNAIGNEILKNIPNARVKYIPAESFINDFLDHLRLGEMEKFKKTYRSLDLLLIDDIQSLSGKKVATQEEFFNTFNALHDKQKQIVLTSDRSPKHLEGLEERLVTRFSWGLTQTITPPDFETRIAILQSKTEHLGYNFQSDTLEYLAGQFDSNVRDLEGAINDITLIARVKKIKDITIDIAAEAIRARKQDVSQMLVIPIDKIQTEVGNFYGVSIKEMKGSRRLQNIVLARQVAMYLSRELTDNSLPKIGKEFGGKDHTTVIHAHAKIKSLIDQDDNLRLEIESIKKKIK
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation. Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (By similarity). Participates in MYC-induced transcriptional activation (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MDELPNGNGAALLKRGRGRRRRHPQSQPRGASVLALPLRPRKIRRHRKSAAASRVAALRARALRSEDSDSKVAVASVRGKRKRPAELLEASRSAEPRPVSARPRSASATLPSRVEGWAALSRNLGTAAPPPPGSHADEPGRPRASPLQQVLTELNGIPSSRRRAARLFEWLLAPLPPDHFYRRLWEREAVLVRRQDRSYYEGLFSTADLDSMLRYEDVQFGQHLDAARYVDGRRETLNPPGRALPAAAWSLYRAGCSLRLLCPQAFSPTVWQFLAVLQEQFGSMAGSNVYLTPPDSQGFAPHYDDIEAFVLQLEGRKLWRVYRPRDPSEELALTSSPNFSQEDLGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLSTYQRNTWGDFLEAVLPLAVQAAIEENVEFRRGLPRDFMDYMGAQHSDSKDPRRTAFMEKVRVLVARLGHFAPVDAVADQRAKDFIHDSLPPVLTDRERALSVHGLPVRWEAGEPVNVGAQLTTETQVHMLQDGVARLVGEGGRLFLYHTVENSRVYHLEEPKCLEIHPQQADAMELLLRSYPEFVRVGDLPCDSVEDQLSLATMLYDKGLLLTKTPLVPS
The following text describes a protein:
Function:
Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MDDLYDEFGNFIGDAEESEEESQHGNDASAYVYDEYPEEEPEEPTGQELMDLDDEGPSNAVILHEDKQYYPTAQQVYGEDVETMVQEEDAQPLTQPIIAPVEQKKFNIQEADLPPVHFDRSFMSDLMNYPEQIRNIAFAGHLHHGKTAFMDMLVLETHDITERLEKKTGRKKDEQLRYTDIHVVERERGLSIKSAPMSLVLQSTKGKSHLLNMLDTPGHVNFVDEVASSLRLVDGVVLVVDVVEGVQVNTERIIKHAVLEGLPLTLVVNKMDRLILELKLPPTDAYFKLKHVIEEVNTVIEATLPGQGESRRLSPEKGNVLFACTSMGWCFTLQSFAKMYADSYAPSNKRGPGLNNEESGINAHEFARRLWGDIFYNPSRRTFTRKGVEERSKRSFVNFILEPIYKLYSHTISESPEDLKDTLETLGIFLKPSQYRTDANVLLKLVCEQFFGPSTGFVDMVVQHIPSPVEAAEKKLERHYTGPLDTTVGAAMKNCDQDGPLVIQITKLLNTSDATGFYSFGRVLSGIARAGTQVRVLGEGYSIDDEEDMSVATISDVWIAETRYNIPTDGVPAGNWVLLGGVDNSIVKSATIVPLVLPNEEEAYIFKPITHFTESVFKVAVEPINPSELPKMLDGLRKVNKSYPLITTKVEESGEHVILGTGELYMDCVLHDLRRLYAEMEIKVSDPVTRFCETVVETSAIKCYAQTPNKKNKITMVAEPLDQGIAEDIESGKVDKKLLLSVRDTIRQGFSWAAREGPLCEEPIRNSKFKITDVILAPEAIFRGGGQIIPTSRRACYSSFLMASPRLMEPVYSCSMTGPADSVTSLYTVLARRRGHVLSDGPIAGTPLYRVSGLIPVIDSFGFETDLRIHTQGQATVSLVFDRWSIVPGDPLDKDVILRPLEPANAQATARDFVLKTRRRKGLSEDVSVAKFLEPELFTSLKETGILDG
The following text describes a protein:
Function:
Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit alg13 to the ER (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
Sequence:
MFSMLRRMKLDPSTYTYRTYVVSSGDNFSAARAVEFETEWLKQSPKLSFPANGSNSTESYAVVTVPRARRVHQSYLTAPLSTLQCFYACFLVLCGRHPEQKSPLPTTNSPYPDVILTNGPATAVCMVLAAKSLRLFHYLKSLFYIKDHQDRDSSRSSQVKRSEDAPAPVHFQLRTIYVESWARVTTFSLSGKLLLPFADRFLVQWPDLAGKQAWRGMRETEYAGTLVD
The following text describes a protein:
Function:
Catalyzes the introduction of a cis-double bond at the delta(5) position of existing saturated fatty acids attached to membrane phospholipids. It is not strictly specific for palmitic acid (C16) but can also accept C14 as well as C18 species to yield unsaturated fatty acids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWFLAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTLFPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFILGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFLISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHVHHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHIPVSLPPDSPEKQKLRKNA
The following text describes a protein:
Function:
Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Domain:
The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.
Sequence:
MFEKAVYPALEELQQPLSQEQFRILKDQLNSEEPTPSAQTKFNYAWGLIKSNHHKQQEYGVQILTELYKSEKSMRREVLYYLSLGSLKIGDYTNAKRYVEALLEIEPENQQARGLLKTIDDKITTEGLIGIGIAGGALAVGLGLIGALVRKNRK
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Membrane; Multi-pass membrane protein.
Sequence:
MTSSLAAQLANVRSLNAERLTSSASLVKHTSYLFPPKTAAQQDLFTVHALGASGWTELSAENASLQRWSQSSLLFGDESRSMDRLMLPKEENDTIDKAVDEFLHLAAPFLLSKGASKCLEWLVRRFRVHEFSVEHVLAAFLPYHDTQQFARMLSICKLDGKPHLQFLLSVKKTASPLPAGVLHTAILAPATTTASLDLLRWISGLLANDVSYQLQVSPHRALVNFWTSTLVQICAARSRPDDNQQLAGLSKSTSNSKKSTKTRAADAQAILTILLPSAVRVAGTASLGQDAQMGGFMLLCTISQSFPLSKEAIQGVLTSLAKLLSTSHVVPAVNRALIACAFALCASPIATSDPLTTQSTSADRLIPDSLTAVLVSSTDASNCIGALAKSYDARAFLAHFIAALTARLSHAPSADLLSAILRGPAVQDNLCIQASELLLRLRLGASVGSSQAQDTAFEAHFVNDAVNEAHRNRLRVLQTVRNRKPHVFDTALHNCTRKHQSEAVIAAIWQTVQAVLAIESGIPLQDASQGKHDEQGRSDILWLSIHSADASQRCLALKQLFKDIKEGRALPQDTMVREALHARIQDSSIDVLQILYSQPAAVLNAFDARTLLTMIAEALDEGRIAVDRFTQHLSFLLNPYLKEHADANDQVARRAVWPHLLHSPSRLANASSAIKLLSQSSNTNGVLSLIASFAAKYEDPTHVNDAIARAVAAHLVSVSAEDRKDWVDFLTSTARPSQTTATASRDLALLSLIHLSDKIAGDDLVSLSETILRNVVLPSLTVLGAPTAEHLQQLSSLTLNDALTSLQHVKQLETLFKHAATEQSAILLVNHLLVQLVRRAEVPAFDTYLTSQVSPELQRAKTILTSLYSVINTAPLPTSLSKLLLRILLFKLGDSSLPFLASIWTNTSGSYTAAVRLAALRHADAYLQAQVQAISQQEARDFQVVVPLLLTALADAEAAIRLAAIACLAHILAICKYAGDLAKASKKKAKELDIFGYESFHGAATSDPMQYIDLVSLAPYLEQIIESKSAFRNDAALLPRLHGELLQIGRQDGRKEVGHKHAMVCFIVSHILCIDSLPSRLVLLQSLSRVSDAAKLEMLLPLIREVVEGNVATATNGLRNVEDRELYLELLFASYDRGCRDVVEQAASGAWPLYLKALEGRDGKRQVQKAAVRALDKAGLFATLSPIMRKESYLHLASVVADPSVPASPEVASALRELKVDSAILIAVLSELREAITSKALSGPESKRARTSLSSDETMKRTCAILAAVLESAVGSRLMCTPALLYELFEVLRVAVDLHSGLLATNGEHMMQLAMSCIEKLVGSLPKSAATIPAEIAQALRADTIVSVIKSSNNPQTFQHALLLLSKIASIAPETVLHNVMPIFTFVGSTVLQRDDAFSFSVVEKVLQSIVPALVNSFRASDAAKKSKFALLCEARAFVRIFTDAAAHVPRHRRQTFFRLLVDILGADDFAAAVAMLLVDRSAHKIVKQSRSDAEQTLQLPLAVVSPHSAMVQVRVLHQVWEEVLRIWANRDETESLSELVFLDRAGRLDKEHVDHESEPLRQIQALIMLIRQVLVSKAFADQMGKVASNQIGEELETFIRLALETVASVRSSQPTIAGLALEVLDAAMPFAPVDNVLAVVSGLVEGQDVAHRTSGFSLFASRVGAMSPTSTDRAAVAAYTPTIVKEAIEVIATSLATPPAGADAESLRQAALDALKTVSSSAQTAEHATLASALPTLIKLGKTSAESERVQRAVPWAARISVFSITRRLATKLGPRLIPHIAALVPFCLSVISRSASATVGSADAVQDESENEKGRAAAAGVNSNKAVLRTGALDTLTGLFGSVSTFMSSYVAQIIRMSISPELKKAMSSVSGSSTASERSLNLLVSTLIRKTVANQLFEATFKVWDQELAVAENDDAVERLVGISEFLGRALRQSDREAISATYKLVYRFLLRALDLGRINVAGNGKLSRASIARIETSLVSLPFMRMVLKLNEASFRPLFMRMFDWAVLDLVDGDEVDVHSEETDAIVARQVVLFKTFNALSETLRSLVSSYYAVLLDQVIELLSTWSKLAARATVAHQSMQRELWNEVMRSIQLSAKHDEGIFWNPSRVAKIIGPILDQMNLLNASWNDKKRFIEAEEFVGAVAPVVVGLLNNVNDQATLKLFNSSLLQRASATRATNSSLIRSTATQLLTHMWAAQNDQLLALVPETIAQLSELLEDDHQPIVAYANQFRSHIEAALGESLESYLT
The following text describes a protein:
Function:
May play a role in RNA metabolism, rRNA-processing, and in a process influencing telomere capping.
Miscellaneous:
MISCELLANEOUS: Present with 2430 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSTVTKYFYKGENTDLIVFAASEELVDEYLKNPSIGKLSEVVELFEVFTPQDGRGAEGELGAASKAQVENEFGKGKKIEEVIDLILRNGKPNSTTSSLKTKGGNAGTKAYN
The following text describes a protein:
Function:
Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of a range of long-chain fatty acids, with a preference for long-chain unsaturated and branched-chain fatty acids over saturated fatty acids. Hydroxylation of myristic acid occurs mainly at the omega-2 position. Also displays a NADPH-dependent reductase activity in the C-terminal domain, which allows electron transfer from NADPH to the heme iron of the cytochrome P450 N-terminal domain. Is also able to catalyze efficient oxidation of sodium dodecyl sulfate (SDS).
Subcellular Localization:
Cytoplasm.
Sequence:
MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQIHTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAHNILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGFNYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLVDSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLLSFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAFSLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHAYKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHISVQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVARELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIKPGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQLDEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENRELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTLSASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSAEGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQASITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMVGPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTVHTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQAVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI