lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)). Transport is electrogenic.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MLKNVQKLGKFLIIICMIFIALSSPAFAATAEENAVAIEGVQTALTFVWLLLASGLVFFMHAGFSLVETGLTRSKNTANILMKNFMTIVLGILIYWAVGWGVMYGADAAGLIGTDQFFLSGADNALWNGWFFQMVFAATGATIVSGAMAERTNFKAYLIYCIMMVAVIYPVYGHWVWSGADLALLTGADSPIVQAIGVPSHDFAGSGVVHSIGGYSALAGVLLVGARIGKFKDGKAVPIPGHNLTIAFLGTLILALGWIGFNGGSTLDGNDPYMNLVVVNTFLAAAAGAVVTMLITWMKTGKPDPSLTANGLLGGLVAITAPCGSVNNWAAIIIGAIAGIIIYAGVMFNENTLKVDDPVGAIAVHGYCGSWGLISVGLFSIGIGNGILADAAYAAEVPGLFYGGGISLLLIQLISVLCSIVWAFGISFIIFKILDAVVGLRVSEEEEIMGLDICEHGIRAYPEYLMREE
The following text describes a protein:
Function:
Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Midbody.
Sequence:
MSTGDLLNNLGRLQRALRVVRYAGHFDTTRAKLGDPAAFLPLIHYTLLAYSHRVSAELAEHGYELYGKSDLRFVEAVFRLLRNEFGYSPRLSTEQFFARGFAELKMILVVDITDICIKRHRELARQAKAELGPRGSTRVENVYGPLVTDNVSPNTSMLYGARRQYDSQLYQTTTNHPLDRDDVDSIHAALFDVDDSDIQPRSPLQSGLPEQLEQTQPTQNSMPASVQAAATAEHSSATHQAATAAMQGVDALARRVQALTARMSNLDGKQAQLMHLASSHRSQGEANESTNSAPPRPRPASPHPTPETNAAWSSELASMRQAMEALSRQVESLAAGMRRMETDVGTRLVLLEAQVASGPNSQQPVNDRRGADAAGPISPPPATLAGTSLATGSRLHTGAAPMASSRAPAAASRSPVTGTTTATTVRAEERAAQAAEPPTTLRATISERQHLTPFAFLARGGPLSE
The following text describes a protein:
Function:
Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is required for transcription of ribosomal protein genes and genes involved in the integrity of the cell wall, and also for proper metaphase progression. Together with HTL1, LDB7, NPL6, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity.
Miscellaneous:
MISCELLANEOUS: Present with 1750 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Note=Localizes to centromeric and flanking chromatin. Association with these loci is dependent on STH1.
Sequence:
MDIRGRKMKKPPACVQCRKRKIGCDRVKPICGNCMKHNKMDCFYPDVPGQYVPSSSSSSNTRQVANGPYLNSYYASRRVSKETAALLQKNPELASLEQIREYNTRLQLLNAQNQLNNRSSAANATLNQQHTQYIPKSVPSLESKPVTSANESSTPLNWVQGPAIFHMLTSPYTQDEIINHEMNFLKGRLLELQEITGKKITGVNLDLKQDSSAQMQSSHSNRNQEEFLTIKKRKLSEDGVTDGDGKPIPESERRPHLNEFKDLDPQFLDTNKVFNVFNSAISEEGRNRLWLLPKNINKSSIFQIQYLIERDPFLFKFFNDLNILIETQFNGPLHDLVASRNSIERNSGISQILKFPSQSITQTLINKYLSTITETNSILPILKPKRLLPIVEQLFPSNTINKPNSKDFETIFQVFSVTNDQLLNLGFITLCLLILFESLNSTVLIPLRDDEHLQLFNVLFNYLPLLKSNLTTLRFEIEKRSMCNIETLRFISLWKYYQFVMDTSSSSSFVIDYDEDMHMACLLSLNHETQNQSHILTWNFIFKNYCWRHLFLGQLPLLMSEPFTNSTPIIDPLLNNDFELIDFEVNLMKYLQSKDQQLSIDKIIQLIKLLKNKNIEVSQGCLTTPSIINNIMDSLIYRNSMLYLNFYLLLQFETLKNYAKFNEILEDFLELSRETLFFVFSNLANIKFAGHEFTFINKSIVVLQTLVLMLLALYQRSFDSSKRTNDANEISEQTDIHSNNDNSKRIKNKNVIHLIINKIAMLLSDYTKNCKKQNKLIENLIIKIKTISKYIKNLEENKVTTSADSNYSINNGFSGISAEQLIKLNHELSKISESLIKTDFYEQRKNSTVSNGVLGAAAPVDSDANSDTFGLTKENFNEVFEAIRS
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MQQLLHRGAAMTQHREEALDASWDDLKLFLACAKYKSFRNAAEELGLTSTTLMRRIDRLEESIDCKLFLRDQSGLTLSDEGTAMIADVAHMERHAFNVFRRASRSSNDTSGTVRVAVTEGPGNFWILPRLIDFQKTYRKITVDLRCAMEQADVARLESDIAIQLEPPTNPDLIVAKLGRLHIYPFVSKEYESLYGLPATLAELKNHRIIKQSAPQVDDTAYARVLGLETLEGIVGIKTNSSVGVLYAVERGAGIGFLPTVSIALGAPFIAVDLGVSHHADLWLTYHKEFRDSERHKIVVDWLKKIFDPKTYPCFRDEFIHPNALVPMMTAAREGFGLKGYVATTPT
The following text describes a protein:
Function:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Sequence:
MTATDAEKLEIVSGFIKDSPPGEINDVFNDVRSLVADDSLLQNTIESTFADHHAKQLVSVQVPSKDYEVILGEYGCIEPSKYVDPRSGQALIVDLVHQTVKSVEPYHSKCSAHLLDQRAALDVAVQEYTASFYPSSVCTVWATEDEALVIAIVANKYHPDSFWSGRWRSLWRLEPKSSMLTGSAKVQVHYYEDGNVQHNSTQDYSVSITASDQEPSTLAATVIKHISKLEAEYQTTLNDQHNRLALETFKSLRRALPISRTKIEWQGILSYKIGSELVSK
The following text describes a protein:
Function:
The M-Pol II complex possesses alpha-1,6-mannosyltransferase activity and is probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins.
Miscellaneous:
MISCELLANEOUS: Present with 7160 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Single-pass type II membrane protein.
Sequence:
MAKTTKRASSFRRLMIFAIIALISLAFGVRYLFHNSNATDLQKILQNLPKEISQSINSANNIQSSDSDLVQHFESLAQEIRHQQEVQAKQFDKQRKILEKKIQDLKQTPPEATLRERIAMTFPYDSHVKFPAFIWQTWSNDEGPERVQDIKGMWESKNPGFAHEVLNHDVINALVHHYFYSIPEILETYEALPSIILKIDFFKYLILLVHGGVYADIDTFPVQPIPNWIPEELSPSDIGLIVGVEEDAQRADWRTKYIRRLQFGTWIIQAKPGHPVLREIISRIIETTLQRKRDDQLNVNLRNDLNIMSWTGSGLWTDTIFTYFNDFMRSGVREKVTWKLFHNLNQPKLLSDVLVFPKFSFNCPNQIDNDDPHKKFYFITHLASQFWKNTPKVEQK
The following text describes a protein:
Function:
Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac. May also act as a transcriptional corepressor for KDM5C and EZH2. Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination. Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters. Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression. Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform. Suppresses breast cancer, and prostate cancer cell invasion and metastasis.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm. Note=Sequestered in the cytoplasm through the interaction with DBN1. Localizes to sites of DNA damage in a KAT5-dependent and DNA poly (ADP-ribose)-dependent manner. On chromatin, localizes to demethylated regions, active promoters, and transcription start sites.
Domain:
The bromo domain is required for interaction with histone H4K16ac; [Isoform 1]: The bromo domain is required for localization to DNA damage sites; [Isoform 17]: The MYND-type zinc finger domain is required for localization to DNA damage sites; The PWWP domain is required for interaction with histone H3.1K36me2.
Sequence:
MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESRLDTFWD
The following text describes a protein:
Function:
Post-meiotically transcribed gene that has a role in late spermiogenesis; required for actin cone progression during spermatid individualization.
Sequence:
MDTLHEHEAGNLYEEQRVDRVGDALTADAGDDADTLEDGQQQQQQQHQQLLGVNRQMAILLDAPQEPPMAVFPARGGLNGPPRLRKKRSFYTMVKPSPPCESQEPEMCLLLASVTRAMRQVREDQRGEYFANYLVENMTSQNYPNGVGLPQHWGEF
The following text describes a protein:
Function:
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function (By similarity).
Domain:
The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity).
Sequence:
MGFLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKTLRDLIHGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQALKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNRQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGGSQGEESVSGSQRTSSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTKAESLIGVYPEQGDCVISKVLTFDLTKYPDANPNPNEQ
The following text describes a protein:
Function:
Component of the trimeric PUCH (precursor of 21U RNA 5'-end cleavage holoenzyme) complex, that acts as an endoribonuclease processing the 5'-end of precursor Piwi-interacting RNAs (piRNAs). The PUCH complex consists of tofu-1, tofu-2 and either slfl-3 or slfl-4, where tofu-2 exhibits endoribonuclease activity. PUCH-mediated processing strictly requires a 7-methyl-G cap (m7 G-cap) and an uracil at position three (U3). PUCH also exhibits a strict bias for piRNA precursors with an A or G at position 1. Mature piRNA production is enhanced by the interaction of PUCH with the PETISCO complex, which is stabilizing piRNA precursors and allows their processing by PUCH.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MIDKIVFEEDEEYDLTQDSFRYGRVTTGASYNLVTGKIPETVLEQVKAKDDENDDVEFEMDHLEDKEAVQKTKTFDELYESQMPKYFEYQSNFSEVNGIWTLLFDQNHYENMSTFELQAAICAALNSKHYMMICVGIDAFNAVTGVEMSAKDRVVFRMALTRAVAGEFQPPLVKVAPKQLTGVSPMKRDISEVTSSIDVLFIPVIGVTDEVENNRFLIVVRVKEISDKVYQISSGRIYNELEGRVVEMSDMNEAFHKLIVEQSISDIQTRRGSMFMLEPEPFLEDSPVIFTGSKEILRENHEIPNILKENSTERSLSQSLLNLLDIQNIGWIFFGTALSCCIYNNAIKPLVK
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Sequence:
MSSTTKLPDYRAHRGIYVRHMSVEFQKKDFTQTYELRNHICTFKHSAMDEVESIEYKPSAELINDQIRLLDTMESQAVSPQLLHGYIEKILKNSPNQPQMLFAKYLNYMRCKEYVQAINCLHHYFEEMDFRSTTNEQKLKKRFCYFPLNLAILHCLLGHNAEAIHALTEAIRLAQEGSDQECLLHAIHWLYWIKKEEHSTESLTLLNQLMKLSENVSSKISGYAALNTIREEVLKGNEPSGIFYRLTTDDALISQSSLNDLSPTLFAEIAAIWSHYGINSLVVLHCQLLLGGFTNEDKRLNDEIIGLQFCKLSSYFEKEGYPSVAMKILDYALTIFPEHTEQAELLEISKKKLAFENALMKGEISLAKALSTELATTDSLEFSYSRAIIMKETNQFAEACNLLYKMLQDADEDKVILRNKLITLPQHRIRILRLLGEIYLESKQPCKAIEYFLQSVTCAYSYHLLDSMIASMIGLAEAQFSIGLSTTALDLLNDIAVSVSSFVSPILRAKFWTMTAKLHWKLANRRLPLRHILNLLDHAGTIFESRNYYFGLREVFYMKV
The following text describes a protein:
Function:
Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton.
Domain:
The DPH-type metal-binding (MB) domain can bind either zinc or iron ions.
Sequence:
MMAFEQIPKKDWYSILGADPSASVSDLKQKYQKLILMYHPDKQSADAPAGSVEECIQKFIEIDQAWKILGNEETKKEYDLQRHEDDLRNMGPVDARIYLEEMSWNEDDHSFSLSCRCGGKYSVSKDEAEEVTLISCDTCSLIIELLHYC
The following text describes a protein:
Function:
Probable chromatin remodeling factor.
Subcellular Localization:
Nucleus.
Sequence:
MECIGKRVKSRSWQRLQAVNKRKKMETVAPVTSPPKKRRQKKPKNYDSDIEDITPTCNDSVPPPQVSNMYSVPNNSVKESFSRIMRDLNVEKKSGPSSSRLTDGSEQNPCLKERSFRVSDLGVEKKCSPEITDLDVGIPVPRFSKLKDVSEQKNTCLMQKSSPEIADLDLVISVPSSSVLKDVSEEIRFLKDKCSPEIRGLVLEKSVPGEIEILSDSESETEARRRASAKKKLFEESSRIVESISDGEDSSSETDEEEEENQDSEDNNTKDNVTVESLSSEDPSSSSSSSSSSSSSSSSSSSDDESYVKEVVGDNRDDDDLRKASSPIKRVSLVERKALVRYKRSGSSLTKPRERDNKIQKLNHREEEKKERQREVVRVVTKQPSNVVYTCAHCGKENTGNPESHSSFIRPHSIRDEIEDVNNFASTNVSKYEDSVSINSGKTTGAPSRPEVENPETGKELNTPEKPSISRPEIFTTEKAIDVQVPEEPSRPEIYSSEKAKEVQAPEMPSRPEVFSSEKAKEIQVPEMPSIPEIQNSEKAKEVQANNRMGLTTPAVAEGLNKSVVTNEHIEDDSDSSISSGDGYESDPTLKDKEVKINNHSDWRILNGNNKEVDLFRLLVNSVWEKGQLGEEDEADELVSSAEDQSQEQAREDHRKYDDAGLLIIRPPPLIEKFGVEEPQSPPVVSEIDSEEDRLWEELAFFTKSNDIGGNELFSNVEKNISANETPAAQCKKGKHDLCIDLEVGLKCMHCGFVEREIRSMDVSEWGEKTTRERRKFDRFEEEEGSSFIGKLGFDAPNNSLNEGCVSSEGTVWDKIPGVKSQMYPHQQEGFEFIWKNLAGTIMLNELKDFENSDETGGCIMSHAPGTGKTRLTIIFLQAYLQCFPDCKPVIIAPASLLLTWAEEFKKWNISIPFHNLSSLDFTGKENSAALGLLMQKNATARSNNEIRMVKIYSWIKSKSILGISYNLYEKLAGVKDEDKKTKMVREVKPDKELDDIREILMGRPGLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARPKYLERLTSTLKKSGMTVTKRGKKNLGNEINNRGIEELKAVMLPFVHVHKGSILQSSLPGLRECVVVLNPPELQRRVLESIEVTHNRKTKNVFETEHKLSLVSVHPSLVSRCKISEKERLSIDEALLAQLKKVRLDPNQSVKTRFLMEFVELCEVIKEKVLVFSQYIDPLKLIMKHLVSRFKWNPGEEVLYMHGKLEQKQRQTLINEFNDPKSKAKVFLASTKACSEGISLVGASRVILLDVVWNPAVERQAISRAYRIGQKRIVYTYHLVAKGTPEGPKYCKQAQKDRISELVFACSSRHDKGKEKIAEAVTEDKVLDTMVEHSKLGDMFDNLIVQPKEADLVEGFSILMP
The following text describes a protein:
Function:
Important role in the capacity of milk to transport calcium phosphate.
Subcellular Localization:
Secreted.
Sequence:
MKFIILTCLLAVALAKQESKDNSQEDFKQTVDVVIFPGQETVKNIPIPQMESVEAPIKNKCYQSIQTFKPPQALKGLYQYHMAKNPWGYTVNRAFPSTRTLQYNQKTMDLSMRAREKIVMSEIKKNIQDYVTKMKQYSKITWPRFVKSLQQYQKTMNPWSCYPYTLLQV
The following text describes a protein:
Function:
Cell autonomous antagonist of the canonical Wnt signaling pathway.
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MGKLQSKHACKRRESPEGDSFVVNAHFNTGRYRGIEDFIARQKNATGLQLATYKGGRQPPVTYKEPPAQEMEKAGGCKPVPVGMADDCFPLEVQLPPETPDPGRRTPFYVVGPNDGDSKSPVEEGEKPGLHVEEFECGVSVEGSDKQEWTFTLYDFDGKGKVTQEDFATLLHSIYEMVGNSVHLPSKSSSKGNKNKTLKLRLTVSPPKNGKAPEKRVETEMEQEEAKDDDGDSGNEGMSEGCETPTRKKSCSANEQMRKLNLHEFVQKSIEKQQQQQQHRIAQLRRHHSDSHNHHHHSADEVRRHRHSHHHHHRGSSSNNRSNVHENPDRRSHYLDLAGVENLNNAPITGMYTSSNSQENNHSRSRSRGHEGHHRSRSHDSQELQGLAKHELHVHKTRSTKDVPHSYSRTTEMHHTQRIKETHGIPKLNESTVARIIEIQQRARMYQDMGRKGQICPVQPSLNPSRTKGRPTGYAAALVSPPGLHGHRRHHRHKEEFKAVQEVEFVEQTGERPASGHVQRHEHHHHHEHHHHHHYHHYHEA
The following text describes a protein:
Function:
Part of a multicomponent enzyme which catalyzes the degradation of phenol and some of its methylated derivatives. DmpL, DmpN and DmpO form the oxygenase component of the complex. Required for growth on phenol and for in vitro phenol hydroxylase activity.
Sequence:
MSVEIKTNTVDPIRQTYGNLQRRFGDKPASRYQEASYDIEAVTNFHYRPLWDPQHELHDPTRTAIRMTDWHKVTDPRQFYYGAYVQTRARMQEATEHAYGFCEKRELLSRLPAELQAKLLRCLVPLRHAELGANMNNSSIAGDSIAATVTQMHIYQAMDRLGMGQYLSRIGLLLDGGTGEALDQAKAYWLDDPIWQGLRRYVEDSFVIRDWFELGLAQNLVLDGLLQPLMYQRFDQWLTENGGSDVAMLTEFMRDWYGESTRWVDAMFKTVLAENDANREQVQAWLEVWEPRAYEALLPLAEEATGIAALDEVRSAFATRLQKIGLKSREE
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis partially inhibits cell growth and colony formation; its toxic effect is neutralized by coexpression with cognate antitoxin MazE6. Acts as an mRNA interferase on ssRNA, cleaving between the second and third bases in the sequences CUCCU and UUCCU. Further experiments demonstrate that it digests between the first and second bases of UCCUU, yielding a 5'-hydroxyl end; digests M.tuberculosis mRNA (in coding as well as the 5'- and 3'-UTR regions) and 23S rRNA, digests E.coli 16S rRNA both alone and in the 70S ribosome but no data for M.tuberculosis 16S rRNA cleavage was presented. 23S and 16S rRNA digestion occurs in predicted single-stranded regions, the 16S rRNA UCCUU site is in the anti-Shine-Dalgarno site and would cleave off the last 7 nucleotides. Non-cognate antitoxins VapB27 and VapB40 partially neutralize toxicity in vivo.
Subcellular Localization:
Secreted. Note=Following 6 weeks of nutrient starvation.
Sequence:
MVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTAIVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MAEAGHTISFPPVGTIPSDPLVTADCCSSELKAEDVLRNSSSEAPTERLNHCQIDQHNASPHRIAETHVSDSVCLHPMSHQNKHDCSGSLMVHKDLNDHSLLSIQRSHSDSLQIFKDAAASPLYCEMGALFCQGREKDVCAQSFPSLVCKQAMPLQQSNTVTTSIRAGSSGSSSPTQPAKHSFIQICEVIPESTCPKFEKPVCCNSHFHHGAVKDTFAAYCHPQPIPAPAQLIPHLVGMDESYKGQGQTGNLLALPRLISSVSETGLDGNRLLRCCNMDCSWSGPLRPVGAHQWVDEKTTSDASTMTSQEDLRDVGVQVGQDSKELPQHVFPEVCLVQQKTSKSRKSPVREVKWDAEGMTWEVYGASVDPEELGLAIQKHLEIQIKETKGIAAKLSRQNTTTSQHSSGSIQKRKKGFLGSLRHPACCSGTTGAVD
The following text describes a protein:
Function:
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence (By similarity). Regulates a photoperiodic flowering response. Transcriptional repressor of 'CONSTANS' expression. The stability of CDF2 is controlled by 'GIGANTEA' and redundantly by ADO3, ADO2 and/or ADO1.
Subcellular Localization:
Nucleus.
Sequence:
MADPAIKLFGKTIPLPELGVVDSSSSYTGFLTETQIPVRLSDSCTGDDDDEEMGDSGLGREEGDDVGDGGGESETDKKEEKDSECQEESLRNESNDVTTTTSGITEKTETTKAAKTNEESGGTACSQEGKLKKPDKILPCPRCNSMETKFCYYNNYNVNQPRHFCKKCQRYWTAGGTMRNVPVGAGRRKNKSPASHYNRHVSITSAEAMQKVARTDLQHPNGANLLTFGSDSVLCESMASGLNLVEKSLLKTQTVLQEPNEGLKITVPLNQTNEEAGTVSPLPKVPCFPGPPPTWPYAWNGVSWTILPFYPPPAYWSCPGVSPGAWNSFTWMPQPNSPSGSNPNSPTLGKHSRDENAAEPGTAFDETESLGREKSKPERCLWVPKTLRIDDPEEAAKSSIWETLGIKKDENADTFGAFRSSTKEKSSLSEGRLPGRRPELQANPAALSRSANFHESS
The following text describes a protein:
Function:
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Chromosome. Membrane; Multi-pass membrane protein. Nucleus, nucleolus.
Sequence:
MNVSLDVSSSSTKEANFNLNLPTTTDTLVSLKRMENKTVTRSRSLSSLIFGPGRKSKDRSQASVFHALVVIFLEYFAWGLLTVPVINVLAETFPTNKFLMNGIILGIKGLLSFLSAPIVGALSDIWGRKIFLILTVFCTCMPIPCLKISPWWYFSLFSISGLFSVTFSVVLSYVADITEKHDRSSAYGLVSATFAASLVTSPALGAYLGERYSDGLVVAVATLVALADVIFIVIWVPESLSRRLSLDTLSWQHADPFSSLRMVAHDSTILKLSLIVFLSYLPESGQFSCFFVYLKLVVGFPPEAVAAYIAMVGVLSVIAQTWILLILTKKIGTKATITAGLSFQLAQLTWYGLGTQTWMMWAAGVLAALSSISYPSISAHVSLLTDKDKQGTVQGVVTGIRGLCSGFGPALFGFIFYLCDVDLSVDGDGTGHMGVGPAFPAPRIHPVPDSNKILTPRRNETETTWMDKPAFEWMLVPGPPFIIGAFLVLLALLCNSALPTLPSGPETSGSAFVLQCEQLLEETRVDKEKRKKVIGLANQIVKALNSAKPKGHKGNYKERIWLKKLGVSFPLLLNDEQIEKQLTTVEEYSWMKPEKIDIIDDSTIRVEDVNEVFVRLVVTMDKLLSSLLPVLKLLDTRDFLNGIYHTKRALVLCSTAAIIKSTVKGELSFVCERGDSLLPILRVSNGDLSVDISITSGPEWIKSVRFTPAIGNIRPSWAHGEKAQSKDSSPSPHLNQLLALSIHESSLLLSIQSRLIHKPKLQDAVLLLQKWAKTRRLRGLTPLFIRGWMIYLLSVGKVNEKKNMMTSVTSFLQSIANVVSGTVVSVDGEKEGLSGSTICPITLWDESGNVNMAGDITERELERIHVESTRTLACLGDLSTASFLFFDRISFIRIFDHYIQLSVSSSVLSSIDLVTDTVSQRDKLNSFIRILSSQIEKGMGERIEYWDVAVIDDFDENEMECMVEEWSVSSERPKEKKEYRILLGFNPSQQWSSPLTMGPMANSPEVASYSSFWKGKAHVRKFADSRICMTMSWGDTPSETIPLKIIAFILSEYWSIAPSSLSWRTSIDRELRGKKSNQERIAKAFSKLSEMLRGVKDLPLSVTNVHAVSPYPDDCVFAETRGGVLKGSSLIPLDNRLPVYKPSVYVQMKLEHSGKWGEDEKAIEALTAAFYIKLVEGLKKLSVMAVATKHDCRINIDEVVFRVEIMNGKMHAMLRKRVETLKNAGASRGNIQPAQHTLELFETKFVREQQLCSSLGGLATAYPAYSECVLMMKRWIGTNHLSPFINDFTMELLVASQFTEKTKKSIPKSGWNAFTRVLNLITSHNWALKPLIVDLMSEWNDEKRARIESSFLSLRPVLPPMVIVCNEDEKGCVWTREKPDPVILRRLISLASQTLSVLMENVHSEKPIDVTRILTRESWRAYDVVLDLVTPLVSRLCKAGGRPWKGSMAVIDWDPVEGFVDEMNAHFGHVAYFFFNRYRPASIGVKFKPHEDGLAVSLTRCGGHKRDSNGRLIVNREEVMEGIKIMAGPLLAKTFIPGLKEKLEKIED
The following text describes a protein:
Function:
Probably a soluble electron acceptor for the integral membrane protein electron transfer alternative complex III (ACIII).
Subcellular Localization:
Cell membrane; Lipid-anchor. Note=Possibly located on the extracellular face of the cell membrane.
Sequence:
MKITLRMMVLAVLTAMAMVLAACGGGGSSGGSTGGGSGSGPVTIEIGSKGEELAFDKTELTVSAGQTVTIRFKNNSAVQQHNWILVKGGEAEAANIANAGLSAGPAANYLPADKSNIIAESPLANGNETVEVTFTAPAAGTYLYICTVPGHYPLMQGKLVVN