lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Part of the plasmid partitioning system, which ensures the equal distribution of replicated plasmid molecules to daughter cells. The plasmids exist as well-organized plasmid foci within the nucleus that stay together throughout the cell-cycle and act as entity during segregation, effetively reducing copy number to one. Plasmid partitioning requires the proteins REP1, REP2, and a cis-acting locus STB (REP3). REP1-REP2 stably associate with CSE4-containing chromatin at STB during S-phase, marking the locus with a centromeric tag, and thereby probably catching mitotic spindle microtubules to the plasmid cluster and coupling plasmid segregation to chromosome segregation. REP1-REP2 are required to recruit the cohesin complex to the STB locus for pairing of the replicated plasmid cluster, a prerequisite for successful plasmid segregation. REP1-REP2 also negatively regulate expression of site-specific recombinase FLP and of RAF1.
Miscellaneous:
MISCELLANEOUS: The plasmid 2-micron circle is a extrachromosomal element that resides in the nucleus and propagates itself stably in host cell populations. It provides no obvious advantage to the host but imposes no significant disadvantage either at its steady-state copy number of 40-60 molecules/cell.
Subcellular Localization:
Nucleus. Note=Colocalizes with the STB locus of the 2-micron plasmid as foci in the nucleus near the spindle pole body. Is expelled from STB during a short interval between late G1 and early S phases.
Sequence:
MNGERLLACIKQCIMQHFQPMVYDESRCVIETTRGTFPVPDNYKKYKTLAFAFVGHVLNTDDTPVIEKELDWPDPALVYNTIVDRIINHPELSQFISVAFISQLKATIGEGLDINVKGTLNRRGKGIRRPKGVFFRYMESPFVNTKVTAFFSYLRDYNKIASEYHNNTKFILTFSCQAYWASGPNFSALKNVIRCSIIHEYISKFVEREQDKGHIGDQELPPEEDPSRELNNVQHEVNSLTEQDAEADEGLWGEIDSLCEKWQSEAEDQTEAEIIADRIIGNSQRMANLKIRRTKFKSVLYHILKELIQSQGTVKVYRGSSFSHDSIKISLHYEEQHITAVWVYLTVKFEEHWKPVDVEVEFRCKFKERKVDG
The following text describes a protein:
Function:
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Subcellular Localization:
Secreted. Membrane. Note=Associates with tumor cell membrane-derived microvesicles.
Sequence:
MKTHYFLLVMLFFLFSQMELGAGILTSLGRRTDQYRCLQNGGFCLRSSCPSHTKLQGTCKPDKPNCCRS
The following text describes a protein:
Function:
May control the interaction of photosystem II (PSII) cores with the light-harvesting antenna, regulates electron flow through the 2 photosystem reaction centers. PSII is a light-driven water plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating a proton gradient subsequently used for ATP formation.
Subcellular Localization:
Cellular thylakoid membrane; Multi-pass membrane protein.
Sequence:
MSIVFQIALAALVLFSFVMVVGVPVAYASPQNWDRSKPLLYLGSGIWAILVIVVALLNFLVV
The following text describes a protein:
Function:
Acylhydrolase that catalyzes the hydrolysis of phospholipids at the sn-1 position.
Subcellular Localization:
Cytoplasm.
Sequence:
MFSCDMASRWRELHGSGHWDGLLDPLDVDLRRCLITYGEMIMATYEAFIGEHRSPNAGMCRYRHADLFRRVDVSHPGWYAATRYIYATANADVHGKVLLRPLCREGRATECNWMGYVAVATDEGAAALGRRDIVVAWRGTQRALEWVADLKLAPASAAGILGPEGADGTDPSVHRGYLSLYTSEDQCSELNKQSARMQVLTEIARLMDKYKDEETSITVIGHSLGATLATLNAADIAANSYNTSSLSPSGETRAPVTAVVFGSPRTGDRGFRDAFHRLRDLRMLRVRNRPDRIPHYPPVGYADVGVELLIDTRLSPFLRRHGSESQSHDLECHLHGVAGWHGDHRGFELVVDRDVALVNKFDDCLADEYPVPVRWKVHHNKSMVKGPDGRWVLQDHEPDDDDDDDDDD
The following text describes a protein:
Function:
Essential protein required for the splicing of group IIB introns in chloroplasts. Forms splicing particles with CRS2. Interacts with RNA and confers intron specificity of the splicing particles.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MAIVASLRDINLFSSLPSTPPMADSSSGTFRPAPPIPIPKYAPSNRNRNQKTNHQTDTNPKKPQSNPALKLPHHRTRYYKPVKEGVISSDGDRTILIGDSGVSYQLPGAPFEFQFSYSETPKVKPVGIREPAFMPFAPPTMPRPWTGKAPLKKSKKKIPLFDSFNPPPAGKSGVKYVEMPGPLPFGRYPKEGMNREEVLGEPLKRWEKGMLIKPHMHDNRQVNLGRDGFTHNMLELIHSHWKRRRVCKVRCKGVPTVDMNNVCRVLEEKTGGEIIHRVGGVVYLFRGRNYNYRTRPQYPLMLWKPAAPVYPKLIQEVPEGLTKEEAHEFRVKGKSLRPICKLSKNGVYVSLVKDVRDAFELSSLVKVDCPGLEPSDYKKIGAKLKELVPCVLLSFDDEQILMWRGREWKSRFVDNPLIPSLSETNTTNELDPSDKPSEEQTVANPSTTISSPKMISLWQRALESSKAVILEELDLGPDDLLKKVEELEGTSLAAEHTYTAMVLSNTDGAAEDYVDEKDRSEEYYSDIDDDFDDECSDDESLDPVGPVGSLPVDKIVRKLRERLK
The following text describes a protein:
Function:
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
Subcellular Localization:
Cytoplasm.
Sequence:
MGGAVSIDLVRGMRDVHPAEFAHGRYIQRILEQTMAGYGYQMIDTPVIEHRELYLRKLGEDLVGKVYEFSFGGRDLALRPEWTASVLRAYVASMQDQPLPLRLSYAGPVFRYERPQRYTYRQFTQVGGEIIGGLPPRADAEVIALACAGLQAVGVTEYTVRIGHIGLARELLSRFALPERTRGLLVWSLERLRAEGIAPVRERVLANLGTPPEGLELPAGLDDEQAARWLERVLTAMQIDLRTGTRSPAEVLQRLLRTLRRADEQPLVEAALEQLARLAAISGPPEHAIPMLADLPGSESAAFRELQAILNLLAAYHIPAERVVIDGALGRRGLHYYTGLIFEIYDREGNQLCGGGRYDDLVGALGGRQATPAVGFAYGLERVTAAATTGSGESPTTVLVAAVSDDDYPYALHVAERLRAGGYIVVLDVRGRSVKDNLRDATRRNYSAVVIVGAAERAGEYVIWRDLATRSERQIPIAMLGRHL
The following text describes a protein:
Function:
Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKKKQVAKARKDKYYHLAKETGYRARSAFKLLQLNKKFNFLQSSQACVDLCAAPGGWLQVASEHMPMSSIIVGVDLVPIRPVPKCVTFQDDITKESCRTQLRRELHKWKVDCFLHDGAPNVGKNWLHDAYSQSVLTLAALKLASEFLCKGGWFITKVFRSKDYQALMWIFGQLFNKVHATKPQASRNVSAEIFVVCQGFKSPDKIDKKFFDPKSVFQEVEAKTRPVNILDFEPKKKKKAKGYGDEAKDLLYMKKTVSEFLGCSQPMQMLSEISEIVFEDDDQKVHPLVTDEIKEHVKDIKRLGKKEIKTLLKWHKKWQKLNAPQVEEVEENEEEEVDSEEEMERKIQEIQENETRELKKKKKVVTKERQKLRERMSNMVTSTNSQEDMELFALSKINSARKMGTVMENVEEFELEEGSDEEGSGSSEEEEEEEEDEGDNEGNPLIHSLEDKVEDDYQTKLWFGKEEFENIADDLDELEEIESARKIYENRVEKKKKEVEEKTEVQKKIEAYNSDSSDSDSDYDVEETLNEAKPVTTTKGKKQKTQKLDAEALALGTVIATSNKRKRDVIDDSFNRYTFNDEECALPDWFLEDEKKRVVKNHLRHHVSKDMMDFYGSKDKGINVRTIKKVVEAKARKKRKATKKMEKARKQAEGISDTADMSTKEKAAHIKNIYKKAGLLKKKKENTTYVFAKRGTGKRVRRPPGVSGKFKVVDKRMKKDLRPQGKNSKQSKGKSG
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MEQKQKKHTHFKKAKKPSGTQTTTNKTKKRENKKLFSVKPKILERQKIEEEINELNSRIRKETPARGVNPLLSESKIGEDYSISYPDAKRFDQFPISKATIQLLNKNRFITMTPIQRAAIPHALAGRDIIGAARTGSGKTLAFLIPLIEFMYRSRWTELDGLCSIILSPTRELAQQIFDVFASIAGERFTAALITGGKDTKEEAKVIRLMNVLICTPGRLLYHLDNTPHFNTTPLRMLILDEADRILDMGFKKDLTAILEHLPKQRQTMLFSATQTKSVQDLIRLSLRHPEYISVDEKAQHATPETLNQTYMLLGDGDKINVLFSFIRTHTNSKMIVFFQTTKEVRFFFETFKKLRVGAVLYLLYGRQSQNSRNEQLSTFTKEKRGILFCTDIASRGLDIQGVDWIVQYDCPEDTAQYIHRVGRTARINHNGQALLLLTHNEEAFIEQLEKAKVPLNRVEPNIARMKNIANDITELMIEVPIIKHYAEKSIDAYIYSLTKMHNKSVFDSAKVDEKAMRQSYGLFADKLEETNKEDHIKFEEEDDDDVVEEAATKAEGDDDDLLEKADEQIIEEVKPKQFDISLKPKRLTKKAIHSVGTYIKFEDSDTEQDNQNDLVEKMEEEMRVADIEDKETAKKELKIKRMKKQSALTGFADVEIADDRKRKSSLTESMKEPKTKKTAEEMLQEKLKGSSLL
The following text describes a protein:
Function:
Regulatory component of the inositol phosphorylceramide (ICP) synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis. Helps the medial Golgi localization of IPC synthase in a COPI vesicle-dependent manner (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MALFRRPNWSALFEKIFIQKSFLGFCSLRVGCEIIIWFAIINKVSGLYGIVSLFQNSDASPWQVLMYVSSVLMLILFSWLAIHIPKSSVPHALILFYVYLIDFLLNVLFTVLFALSWFSKLVQSDSSSTEESADSDPSPSLLYLFFQAESIPSLLLLIFFASLKFYFVLITLSYSNKLIVDSGIRPQNLPPNFSGRVTRLLMKPYIMAANRSYLRNHTKRFTDSIELEQRLMDEVV
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. Regulates trichome branch positioning and expansion.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLTRYQIRNEYSLADPELFKAADKDDPEALLEGVAMAGLVGVLRQLGDLAEFAAEIFHDLHEEVMTTAARGHGLMARVQQLEAEFPSIEKAFLSQTNHSPFFSSSGADWHPNLQMEQNLITRGGLPHFVMDSYEECRGPPQLFLLDKFDVAGAGACLKRYTDPSFFKVEAASSGIATVEVQRGKKIRKKKKGSRYKNGETPEVVPTSHAKLHELFLEERSENGHSDPARLVKLKRRLFNGSPFDLKPGKSYMQKFVLTPSPDRKQVCEDSVTRSPLKLTLDNSSESRYEIHEVSVASPVKQSSHGGESTSSSPSEREATLKTFMDELNGEPVDSRIIKVLNPIVDREMDEYPLIVQKMVIEEESSVDADGKAEGTVDGDHSDDMTSEVENYMDALTTMDSGMETDNEYKPMNGQDFMDVRAHGADSDANEEQLDAQANFSDSQSIGNSSLSEGGNSSFKKGTSSFSYSDTLSNVAENTASDGEGAGKWFPSISSTENYPRDIADLPSDSPSVFVESGITESHHLVTFNDTEEDKIPDSGEASRSSCLTDWNLVFLHAAPVAGSMVSPLAGPELDEASSGSIEPGSESPNSDRNGLNLADFPSQLGHDTSLTDSSKTHSVGELDHEDQKMLTDAVVLVSNVSDLAFEKKGSDDSVNGVLQTDYAAEHSTMTPAEERFPKSTLPVVELDSGVLSLPDNLDFVKPDVLVSEVDDAIATRETRAENLTLVVDTSETECVSEHHFSDMTIDASQLELDSSKLGVPCSEVNINLEEISNGFDAEENIAFTKVDITRGDAASFEHQSLSSDKPILEDHVNLDDAVTETGQAEDMAVSSAASSGANNEDVSNVICPSSELVCSPPRNATEPLEALSIPEDPHLTRLDLDEVISAKPLSESQVQMEVTSIDWDSNPYKPVSEDHPNQEVSEVHNLSLELSNQESETKDNHQHHYAEASDNTVCLPLCYLPESGNTLEQSTEVQDDQFSAESSHADNTNTLLSSQTSSTGYLVGTGIPLEHTLELQSDQLDRGCLKLGEASSISTDLQSESSCLKDLSSQEHLLQSFCQERNATVLETNPFDSAFPSFGVLPVPEASQVYPEAMPPLPPLPPMQWRLGKIQPASLDADRDMIDNSEGTFPLIQPFMVDQQVHFDFPSLDREIAHPSNPFLSLPVEESRMFPHSTTESMGNSLLPTPLLSETPIIDNDAHCQQDHLRSDTTQSVSSSLALPEMSDERHEHGFLPLGGESAQSSSNPFSLEPNIEHTTAVNDPMPTQGLPIHPFNQSAPKTGLDMKFPGQSSQSSEEELGNSYGKSAAPLTMEEEPHHDFVTSQGLTMWPPTALAMTPPTSEVGKPNGNKIPRPRNPLIDAVAAHDKSKLRKVAELVRPQVGPKVEERDSLLEQIRTKSFNLKPATVTRPSIQGIQGPKTNLKVAAILEKANAIRQALTGSDEDNDSDSWSDS
The following text describes a protein:
Function:
Required for ciliogenesis and for structural integrity at the ciliary tip.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MKASGGPQKLRFTIHACSGEDTDYPVRELLYHSPQTRGWQSPRFCKYPQEIVLRLEQTCKVQQIQILAHEYKIATRVEVFVGAPQNPLDTDPNNCIFKRLGYLSFDSNERSNHQARELKSVHVNVQAFLIRLLIHRCHVNKLNIYNQVGIIALNLIGERVAPAPEGPHGFLQLHPNIPTAQPYYNAAAADVADINLDLHVDTVTAVKIRELARQKDEAVAREDYDTAKMLKASIERLKVVGQKIAQLEARKRAAVEKEDYDTAKVIKADIDKLRAAGEGAAMAAGAVANASKNPDEIFNRVLGKKGSVGPGGGNQPMLQLPYDDQPVGGRPGSGAPPRPGSGAPPSARGGGSGPTSPQGNFPGGPTVEEPDEEYHAGPQTFQSQASGNSRHQAYDERPAMGRGRYTPSEEQMAAVSAARKAPVHQAEDDGVSAPAGWPGDLPAPEQLAGAIAKDAEALGDMAGEYVARAFFSKNWQLRDAAVAYLTKEVSSGGMEGKREAFRTLVGVVRRGMKDKVANVYLSCLALLPALVDSGLGGGGREIEGMSEQLLPALVEKLGDNNARLREASKESIMFLAGIKDAALPAHTSIFVKPIKNQTAWRPVLGILQLLRDLVPLVGVSKAGDGFDLAELMEFVGKAYNSPNADVRSEAVRVTKEVHDLVGPAIRKCMPKDINPKIKEQVDAVLGGGDAPAAAAPPPAAAPRAAPARAPAAAAAKPPAGRGGGAPKPAGKAPPPPPPPPPPAPDDPAAFEAELASREDQLGPAHPDVAEACSNLAILYNQKGEYDKALPLYERALKIYEKHFGKDHPEVAHTLTDLAVLHLEQGREEVGRPLLERALLIQEKALGPDHPDVLAIKDVLNSD
The following text describes a protein:
Function:
Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube.
Subcellular Localization:
Secreted.
Sequence:
MPVTFALLLFLSQATADPCYHPGGQPRFCLPPVTQLAGMAASCPQACALSPGADPGPRATCNGSLTLALGGPFLLTSISLRFCTPGPPALVLSASWATGGPWRSLWRRPAWPGALGGPEKVTFRAPPGPKSSVVASHLRMEFGGRAGLAAAGVRGRCQCHGHAARCAARARPPRCRCRHHTTGPGCESCRPSHRDWPWRPATPWHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGVCERCRHHTAGRHCHYCQPGFWRDPSQPITSRKACRACQCHPIGATGGTCNQTSGQCSCKLGVTGLTCNRCGPGYQQSRSPRMPCQRIPEATTTLSTTPGAYSSDPQCQNYCNISDTRVHMNLRRYCQQDYVLRAQVLASDGAGPAWRRLAVRVLAVYKQRARPVRSGDQDAWVPGADLTCGCLRLRPGVDYLLLGSAAGGPDPARLVLDRHGLALPWRPRWARPLRRLQQEEHAGGCRGLRPPTPSPGPEH
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MRVRIALAEKGIEYEYREQNLLNKGPMLLQMNRVHKKVPVLIHNGKPICESTNIVQYIDEIHTDGREMRAVKLERQEEMTKEFIAILKTLEEELGDKPHFEGENFGFVDVSLIPLYCWLETECPKIIAWAKRCTQRKSVSKSLKDEKKVLGFVQR
The following text describes a protein:
Function:
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity).
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane localization is probably regulated by its interaction with KSR1.
Sequence:
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELDLDEQQRKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFIKRSEGEEVDFAGWLCRTLRLKQPSTPTRTAV
The following text describes a protein:
Function:
Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5-phosphonooxypentane-2,4-dione (P-HPD).
Subcellular Localization:
Cytoplasm.
Sequence:
MHVTLVEINVKEDKVDQFIEVFRANHLGSIREAGNLRFDVLRDEHIPTRFYIYEAYTDEAAVAIHKTTPHYLQCVEQLAPLMTGPRKKTVFIGLMP
The following text describes a protein:
Function:
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
Sequence:
MATMTKKKLISTISQDHKIHPNHVRTVIQNFLDKMTDALVQGDRLEFRDFGVLQVVERKPKVGRNPKNAAVPIHIPARRAVKFTPGKRMKRLIETPTKSS
The following text describes a protein:
Function:
Insulin-independent facilitative glucose transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region.
Sequence:
MTMVPVQNAEEPGQQCQKMRAAESEGNNSPGCARPQLPAPRGCGMFTFLSSVTAAVSGLLVGYELGLISGALLQLSGLLALSCRQQEMVVSSLLIGALLASLTGGFLIDRYGRRTAIILSSCLLGLGSLVLILTLSYPVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFASVFHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGYDEAASKVLGRLRGISDTTEELTAIKSSLKDEHQYSFWDLFRSKDNMRTRILIGLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTVPATLFVDQVGSKTFLCLGSSVMAASLVTMGLVNLNIHINFTGICRSHSPVNHSLEDLAFYGQGDLPASNNSLKELFVEKSPNSKNPLMSIRSDTERQRELTWASVPSVETSRPSPTQSYQEMGPGDVPEFLKWLSLVSLLFYVAAFSIGLGPMPWLVLSEIFPVGIRGRAMALTSSMNWGINLLVSLTFLTVTELIGLPWVCFIYTIMSLAALVFVVLFIPETKGCSLEQISMELAKSNYVKHNIYLMSHQREKLVPTELQKTKHQEQFLECKKLCGKEQSRHLFQEH
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MGDQRTVSMGGPESEELRNALPCVLAKLELSNHKQRQWLLENSAIIDYSGWLRELLECKTYGMVVEHLCARNTLLPPQDAVLEGRMTVALDLDNTLISPSSILWRSQCDFEPPTQLALSSSWIHVLGLSDCTLWHDTRLGKEALFKDLAILGRDLRKVVLVDNDPGFFCQPGSGNEIVIGKFTGQRSDDGLLKLLPVLQSLAQLDDVRPAVRTYQQPQAQGGNQTRKREWVAPMESPLEWVAPGALSLICDEEAHKMSISLSHLRPSEGLVYMSMRMLRVISDGSKP
The following text describes a protein:
Function:
Participates in the inhibition of the host immune response. Redirects newly synthesized major histocompatibility complex (MHC) class I heavy chains via the SEC61 translocon to the cytosol where they undergo proteasome-dependent destruction. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
Subcellular Localization:
Host endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MNLVMLILALWAPVAGSMPELSLTLFDEPPPLVETEPLPPLSDVSEYRVEYSEARCVLRSGGRLEALWTLRGNLSVPTPTPRVYYQTLEGYADRVPTPVEDVSESLVAKRYWLRDYRVPQRTKLVLFYFSPCHQCQTYYVECEPRCLVPWVPLWSSLEDIERLLFEDRRLMAYYALTIKSAQYTLMMVAVIQVFWGLYVKGWLHRHFPWMFSDQW
The following text describes a protein:
Function:
Regulatory protein of the TOL plasmid xyl operons. XylS activates the xylXYZLTEGFJQKIH operon required for the degradation of toluene, m-xylene and p-xylene.
Sequence:
MGSRDWIDLARDAETGIETLRAHFEGHAYDPHWHDSYLIGYTEIGVQQFNCRRRRHDSTAGQVFLVEPGEIHDGRAPIAGGFTYSMLYLQPDWLRRELRATFDDAPSDRDPGFHANLTEDPRLTLAIAQAFRVLHGRELRLLRQTALELVLERLRVHLGWREAKPFDPRLPLVAQKARDYLHAHFYQDIGLDELASACGTDRFRLNRAFKAAYGLPPYAYLVQLRLAKARQMLAVGGQPADLASALGFADQSHLGRWFRRAYGMTPAAYRRQCTQLPD
The following text describes a protein:
Function:
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MSLSSPTSACSSSRCYSSGLSFPIGFGSNPINVGLVCYPKRYSIAARKFVVACSSSSSDPLLVKAAKGQAISRPPAWMMRQAGRYMAVYQKLAKKHPSFRERSENTDLIVEISLQPWQAFRPDGVIIFSDILTPLPAFGVPFDIEEVKGPVIQSPIRTEEDMKRLHPIDFEKLQFVGDSLKILRREVGEHAAVLGFVGAPWTIATYIVEGGTTRTYTVIKNMCHTAPDVLRALLSHLTKAITEYVVYQVEHGAHCIQIFDSWGGQLTPEMWERWSKPYIEEIIHAVKKRCPDTPIVFYINGNGGLLERMKGTGADVIGLDWTVDMADGRRRLGSEVSVQGNVDPAYLFSPLPALTEEIERVVKCAGPKGHILNLGHGVLVGTPEEAVAHFFETARNLDYQTLFQNHVPAEKAEPELVV
The following text describes a protein:
Function:
Bifunctional enzyme that mediates C-3 epimerization of the second intermediate followed by reduction at C-4 during serogroup O11 O-antigen biosynthesis, thus catalyzing the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen.
Sequence:
MKVLVTGANGFVGRNLCAHLAERGGIEVVPFTRESSVGNLPELIRSVDFIFHLAGVNRPEKPEEFKIGNSELTYALCEAVRSNGRAIPLLYTSSIQAEVDNEYGLSKRAAEEHLQVLGEDIGCPVYIFRLPNVFGKWSRPNYNSAVATFCHNIIRDIPIQINNSSAEITLVYIDDVVRTFMKVMDGKLSNAVSLQVEPQYQISVGELAEQLYEFRNSRKSLTTARVGSGLTRALYSTYLSFLPEDSFSYDVPMHSDPRGTFVEMLKTADSGQFSFFTAHPGVTRGGHYHHSKTEKFLVIKGMARFKFRNILTGAFYEICTNGEKAEIVETVPGWTHDITNVGTDDMVVMLWANEVFDRENPDTYACSVGEGA
The following text describes a protein:
Function:
Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific threonine residue of host Rho GTPases RhoA, Rac and Cdc42. The resulting AMPylation prevents the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in infected cells.
Subcellular Localization:
Secreted. Note=Translocated into the host cell via the type III secretion system (T3SS).
Domain:
The fido domain mediates the adenylyltransferase activity.
Sequence:
MISFGNVSALQAAMPQARNEILNEGKLSIGGKEYTINAATQEFTRANPTSGAVARFFEATGKLFREGSTQSVAKAITKAVFDNEQGQAQRLQTSSSVEHGQMLFKDANLKTPSDVLNAFAKLDSKMVKSHAAELSQLAERAMTEVMLETDSGKNLKALIGDDAVKSLAVRVVKDYGGGVAAAQKNPEVRINQMQAVFDMEVMHLKAAQRHIEGLASTDLNQGVYAEGLPEDAFNKAGVTNNVERAAAWIINASNSKGNDAENITSLLKEYATNGKDLLNMDNLKELHARLVPNVERDYRGPNISGGTLPSSIGGEGMLKQHIEGFLKENPVADKDLGKHLFAGVIGYHGFTDGNGRMGRMLYAIAELRNDSFNPLAMNAENSLHGIK
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTFWDHLDELRRVLFRVIGVWFVLAIGYFVAMPYLFDHVILAPCHNDFVFYDLLRFIGQKFDLTDEFFTQEFKVKLVNINLAAPFFIHMSTAFWMSVVTAMPYIFFEVWRFINPALYPNERKGVRKALTIGTGMFFIGVLMGYFMVYPLTLRFLSTYQLSSEVENILSLNSYIDNFMMLILCMGLAFELPLVTWLLSLLGVVNKSFLRKYRRHAVVIIVIAAAIITPTGDPFTLSVVAIPLYLLYEMSILMIKDKKEVPELEEEEEEEGVAKV
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of 2-phosphoglycolate.
Sequence:
MDIGSNEILVASDYDRTLASEENNFVISPIVSQKVNEFSKKYKFVVVTGREKKFIDKLAVGLKPTAWILENGSLILFNDREFVLCEKSWFERDRKKIIEILDNLKVRYSIGRIILYVDGYGSKLDMLSEIEKYGRIEVNRNDAMILPKGVDKGVGVLKFKELTGFKGKIIALGDSENDYALFRVADIKVAVANAIPQIKEIADIVTENPNGLGVVEILDKILSGNFGKEVDIY
The following text describes a protein:
Function:
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
Subcellular Localization:
Cytoplasm.
Sequence:
MNILLTNDDGIEAEGINTLAELLSKYHDVIMVAPENQRSASSHSITIYEPIIVKQVKKPYNIEAYSISGTPADCVRVALDKLVPDNIDMVISGINKGLNIGNDILYSGTVSAAIEGAMYKVPSMAVSAQFIKNKKENYKIAAKYALRMLNRLKKEDLKNDVVLNLNIPFCSEEEIKGIKVCKVGNKIFNTRFSEEIDEEGNKVLKLEGDINKDIYEGTDVYYIRNKYVTLTPLHYDLTNFNILEETEQLFLS
The following text describes a protein:
Function:
Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.
Subcellular Localization:
Mitochondrion.
Sequence:
METVQELIPLVKEMMAQKRKGKMVKLYVLGSVLALFSVVLGLMETVCSPFTAARRLRDQEAAVAELQAALERQALQKQALQEKGKQQDTVLGGRALSNRQHAS
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MGFGESTQGNQRKLDGPGKVSTELSLVNLEAKNLHPKPECNQPIEHIPTKGMKCTPLLPLPTEHADDEPIYVNAKQYHAIIRRRQRRKIVGSEDKVAAIRKRILVEARQKQAKLRHRGKGGRFISIEHPLELSMDDQISKNGGSASPSSSTVSENSSNVNGFTGDL
The following text describes a protein:
Function:
Probable oxidoreductase (Probable). Lacks peroxidase activity. Inhibits the peroxidase activity of PXDN through its interaction; [Isoform PMR1]: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs.
Subcellular Localization:
Secreted. Endoplasmic reticulum. Cell membrane; [Isoform PMR1]: Cytoplasm. Note=Associates with polysomes.
Sequence:
MEPRLFCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHRANEHLALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQKKRSAQYSYPVDKDMELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITALREQINKLEARLRQAGCTDVRGVPRKAEERWMKEDCTHCICESGQVTCVVEICPPAPCPSPELVKGTCCPVCRDRGMPSDSPEKR
The following text describes a protein:
Function:
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MIEVGDLKKGMFIIYDGEIYRVLEASKHFMGRGSGLIRTKLKNVKTGFVREVNFPSGEKVQEAELSFRKAQYLYRDGDHYYFMTLDDYEQYALSEEEIGDAKYYLVENMEVDLVFHEGTPIGIELPTTVELTVVETEPSFKGDTVSGGGKPAVLETGLKITVPYFIEVGDKIKVDTRTGEYVGRA
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MTGSNDLLPRLSSDSGSNDFPADVELSLGLSLNGKLGLKPERLVGKDNNINNNKLYRASSVTDLVNFPVDVELTLYSPLTRTCSLPPETEVEWRKRKELQSLRRSEAKRKRVEKMKNVVVVKGKVEEDLEANRRGLKRSPTPSPSLSLPPAPLMRFSSQGSIGSQESGGSSGVSDLDSQPFSGTNRETSETNDRSELNKVKCNPKSKDHKHRAYDERMPCVSTKGDGPDGKRIQGFLYRYGKGEEVRIVCVCHGSFLTPAEFVKHGGGGDVEHPLRHIVVTSLFT