lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Methyltransferase that can methylate proteins and, to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. It however only plays a limited role in arsenic metabolism compared with AS3MT.
Subcellular Localization:
Nucleus.
Sequence:
MHKIYSRSSEVLCQLPKHIYSPIKYIAFKSCFQETKNKYSRVSLIQAKRASRSLDNIGICLEVGCGSGVVSTFVASVIGPKALYLCTDINPLAALCTVETALCNNVNIQPIITDLTVGLLPRLHGKVDLLLFNPPYVVTPSAEIQNHGIEAAWAGGKNGREVMNRLIPLVPTILSEKGLFYIVTIQENNPDEIIKILERRGLKGTKVLCRQAGRENLSILKFCRS
The following text describes a protein:
Function:
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
Subcellular Localization:
Cytoplasm. Dynein axonemal particle. Note=Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia.
Sequence:
MDADRLAELQLTRAEMRRIGEALQDRRFRELLTEYVEEISSPENRRRYEEEIRRLEEERGAAVQFIHPTPHHVLKGRGPSGKCFINICSDQLIEKPRSEAATDDRGRSGHSWRIPYSLTPGRAGRDAAGAPCVLFDAVFHPDALLMAENNARFMTLIHRTATGGIQDNFRIRLEHVTRLKMMKYKGEPQPTMIRRPNPGQTEAADRGPQQTTGPQQPTGPQQPTDPQQPTDTQQPTDPQQTTGPQQTTGPQQTTGPHQPTDPQQTTGPQQPTDPQQPTGPHQPTDPQQTTDPPPTAPQYRLKYRSVLDLQDYRCCRDSGSAGRPTAIIIEVEVPRLRSAQEAELRVEERRLLLEAPTAEYRLELPLAYPVEEERAEAQFNHTHRLLTVTLPVLKRRRVEEEERRAEEEESRKGGDEDGELHPDCGPDPPMMELQTEDTHTPAADTHTPAADTHTPAADTHTPAAETGAGLGSGVALLSSSNVISVCGADVHQQLEEPGDPSAHTDPADTHPADTDPADTDPAHTDPADTDPADTDPAHTDPAHTDPEMESRIAGLHLQNTLCFQLD
The following text describes a protein:
Function:
Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MADEERVPAPYFQDDEEGGASDEGEGVDLIKSHGNLVGSGGEDSSDEEEDDDPEEARRVAEGFIAEDDEEEEEDSEARRDRRRRRKKKRKQNEQDFEVDEDDLELLAENTGQPRRKEAGRLKRFRRGSASPPADDEAAARQRTLDQIFEDDDEDEDDIRSGRRGVNYDDDDEDLPSVGQALRAGVARKQREVVGAYEDDGLDDFIEEDEDDEEMQGLDEEEREARRQQRREEKRKARLSGSAADPAKAGIDHEAWDEIHEIFGNGEDYFWALEDEEEDAFDEEKKNKMEYKDIFEPAQIAERMLTEDDERIKRIDIPERLQLACPGEEGLKLLERKLTDTELFEAAKWASTRISQRTAAEFLDEAGLFHRQRSEFINAVQLMLSYMLNDLLEVPFLFQHRFDELEHLTFDEVERQYRSIDLLTRRELYTLSGLGLKFKTLLVRKDQLRATFNKIHVDVKTEPIQDDELDGGLDAMPADESRAARVESSQRQRAIFEDMLAQAASLEEISDITEYLTLRYGQQMRDAQALTSNGTDQAASDLQGLTLTSDPLVSATPAFKKPSLVGQYERNKKTVLAELAKKFGITSDELASNVTSHTRQYSPRDPEESPFKFAEQFTGSAWGAHSPEIALAKAKMMLSQEIGKDPILKREMRQLFKDAAEINIEPTERGMTVIDDQHPYANFKFIANKPARLVPQNPSQYLQMLQAEDELLIKLDIDLKDVVLTRFEARLYNNYASEGVGELSNAWNEQRRDVIREALKTHLVPNGRIWLKEFLREESRETLLRHVDVLMTKRVQEGPFMSKSMMARNRDPKIEEEDRIPRVLAVSHGGGDPRKDVVQAVYLDERGRFREHATFDDLRPLSARQMQERELELERTRGKAEFVDHRADFVKLLKQRRPDIVVVSGWSVRTAELKRHVQELADTAHQEICDADRLHSDLERDQAVIDVVTCHDDVARIYQHSSRAAEEFPELSELGRYCLALARYAQSPVNEFAALGSDLTAVILDPNQRLLPQDRLRLHFERCIGAVVNENGVEINQAMTSTYLQTMLPFVAGLGPRKAHALVNAISTKLEGTLINRTLLISRNILTFQVFQNCASFLRIEQDMLLEADEDDVPDVLDSTRIHPEDYDFPRKMAADALNKHEEDLEGEHPSLPCKELMEDADPADKLNTLDLDNYATMLFERKGERKRATLHSCRTELIKPYDDLREKQSEPSLEEMLTMFTGETSKTLAEGFVVSVEVTRVQEGNRMQEGHIKCRLDSGIEGTIEAEHAVEHYTPGSVRLRDLVRPQQTLDALVRKIDYKMCTVQLSISPWELQHRATHQGKTPIDIKFYDRRKADQWNEHAAAKAKLRIQARRQNRVIDHPNYHNFNYKAAVTFLRSQPRGTVVVRPSSKGDDHLAVTWKVDDDVYQNIDVTELDKESEYSLGRVLRIEGMGSYSDLDELIVNHVKPMVHMVEMMMNHEKYKGADEEDLHRFLTNWSLANPSRSVYAFGLNKDRPGYFNLSFKANRDAAIQTWPVKVLPNAFKLGPADQLADVAALCNAFKTQYTTQASMARGAKTPYGGGRTPAPGMGGATPLGGRTPYGGVRNGMAGSATPGQGVAGGYTTPMINVASATPNPYGGAYGRNGAAGGYGAPAAGGPPGRPPSMPGAPPMMPPGMASGGGAPSYAPPFAGAGEPGPPPARPPVPHGMHPDRFAQAEYGGASQQSYGENSGGAGGYGGGYRGY
The following text describes a protein:
Function:
Involved in the maintenance of the Golgi structure.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein.
Sequence:
MQPPGPPPAYAPANGDFTFVSSADAEDLSGSIAAPDVKLNLGVSGDFIKESTATTFLRQRGYGWLLEVEDEDPEDNKPLLEELDIDLKDIYYKIRCVLMPMPSLGFNRQVVRDNPDFWGPLAVVLFFSMISLYGQFRVVSWIITIWIFGSLTIFLLARVLGGEVAYGQVLGVIGYSLLPLIVIAPILLVVGSFEMVSTLIKLFGVFWAAYSAASLLVGEEFKTKKPLLIYPIFLLYIYFLSLYTGV
The following text describes a protein:
Function:
Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MHSLPPLTNTVFSLSFLDDWCYSSQAKVLNCSGPELWPATCKGFKQSPVNIVISNALSDPRLKVNFKYIDYDGQHPWTIVNNGYTSELFLSISGGGLEDTYRAMYVQFHWSDSLRKGSEHTINGKTYPMEGNMYCICTWVHSEGSRDSFPNVILTSPLDLLSPLDNKVTTKPMSLYDLIPDLKNMTKFFRYEGSLTSPSCPENVIWTVYKDPLQVKEEQILQFSKKLFYNEKGKTDIPMANNYRKMQRRGHRHIYSNRVGRLLPHTWSVFLTPLLTCFLAIFLCWEFWMWNL
The following text describes a protein:
Function:
Mitochondrial RNA-binding protein that acts as a general translation factor. Plays a critical role in the synthesis of all mitochondrial DNA-encoded oxidative phosphorylation subunits, which are essential for mitochondrial respiration. Essential for the expression of iron-sulfur cluster (ISC) proteins as well as other heme proteins related to iron-sensing, and thus plays a key role in iron homeostasis.
Subcellular Localization:
Mitochondrion.
Sequence:
MQFIKRTFPRRAFVDLLLNRFCLREFATTYSVSVSNARKLVRKRLLIADALKFKEQVNNLNEFRNKKTKSSLIRNDGFKLAKNVSSLLQKESLEKALHLLYERSNAKKTVAYNLVLQYHLAKGHYNAAWSLYNDMKKRQQKPSDHTYSILLKGFCDAIEKNKQGNFSKLREYSEKVTASALKESNNVTSNLHHIRIISKCSLKLKSMVLVSMIIPSIKQTLDFYSGSQILRLLNDFSMFNPEQREEVLKMGTNLWNYFVLECQKKGIAVDESLICSFVKLLATSNSPQVRNVGLNILTKVMGLEYQIFEDSNLRYPLPPYCDCTSRSLVTALQVIRQIQNGDLLARYWKYFEESHKFDLNLQVYHEKLRNLVQQGQAAECLNTIKRMSHNGPFPTQQTFLIVLSLCKRPKFYSYTKSFLDLAKKLNVPVEAT
The following text describes a protein:
Function:
Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MPKVRSVNSPPDGGWGWMVVASTFFVNMLTIGNMKSFGVFYAEFREVFQESAGITSFISSILGASVLMFSPFAGALSNLTSCRTAIMAGGVISAAGLVVSYFAQTMVQLFFSVGILTGFGFSLMFSPSLAMVGRYFDKRHATANGIGVCGTGIGIFAFPPLYQFLIDEFGWRGALLIVAGTALNGCVCGALMRPLHFKDDRKEENVNIEAQGITDTEPKKRPHHFCEKIMESFDVTLLKHRPFLVYCVSLFAISLGNSMIFVHLVAHAQNVGIEKTAAAFILSVLGISEAVSRPLHGLLSDKINISKVYYYMVNNTGMAVLNIAIPFGKTYTELVACMVLYGLFSGSFNTLIAVMVREYSSVSRISSGLGWALVFEGAAYLLGPPIAGWLYDATGNYGMSFYAAGIFILLSVLVLFIIPCSTTGKSLSLVSGGRSEPKQNGVEAVAFRNLGRDGRETVRIDSGQSNPGFVVNALT
The following text describes a protein:
Function:
Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Also acts on 1,3-diaminopropane and 1,5-diaminopentane.
Subcellular Localization:
Cytoplasm.
Sequence:
MTRSVRLELFRNKKLKETKDAHGLEQGPGAQREEKQKTKMAKFKIRPATASDCSDILRLIKELAKYEYMEDQVVLTEKDLLEDGFGEHPFYHCLVAEVPKEHWTPEGHSIVGFAMYYFTYDPWIGKLLYLEDFFVMSDYRGFGIGSEILKNLSQVAMKCRCSSMHFLVAEWNEPSINFYKRRGASDLSSEEGWRLFKIDKEYLLKMAAEE
The following text describes a protein:
Function:
Together with Abl, involved in embryonic axonal development.
Sequence:
MASEVAQIPAEETPAVAAAEKSEEPEKSAAPPADSAAAPAAAPAVEKAEDADGEKKDGEAGKQDKQQDGEEPKKDEAVAAPVATKSEAPPAQKFNVHKTNFEKDIIYLYQFSRTPLLPSLSPYCLKVETWLRLVGLKYENVDHKMRFRSKKGQLPFIELNGEEIADSAIIIKELSSKYEKYLDSGLTAEQRNVSYATIAMLENHLIWIIFYWRAKYPDNVLKGYKVNLQHALGLRLPNSILNFFFKITFGRKWFQGTKKLKAHGIGVHSAEEIEEFGKDDLKVLSEMLDCKPFFFGDEPTTLDVVAFAVLSQLHYLSKDIAYPLRDYMTEKCPNLIGHVSRMKDKCFPDWDEICTKLDLNAHIPKPEPETKEGKEGGEQEKSNEQEGTEGDKIEKELEKDKSNEKESTEENKEKEETK
The following text describes a protein:
Function:
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Sequence:
MAKDKKTNPESKKSFPTAFFFLLFGVIFGVVTVQNFFSAKKASVGFSHQLEHLVNLKLLIPEESRKTALNDNLVSFSGRFREVVPAEGQVRYQYLDLIERKHQIDFELEEASKSLTVLSKEVRNAITWFSAISGMPIPEAGYTISPRTDVGLSVLEPLVVYGPVDAQIVNLAALENRVRSLPKSTESLRVFGSDLYALIGKYLSPALGIGSESLKKEIKDLHQQVENSLTQVIEGDQAVALYKTVLETLHRISLALVSPEEGTRFHQLRSVRLYREDFNRCVKLLGESDETQVQLDKLRGELVQAVWYFNNQELSSRALEKQDPEVFSRWFEGAKQEWAAFSSNKSLSFRAPDQPRNLVLEKTFRSEEPTPHYSGYLFTFMPIILVLLFIYFIFSRQVKGMNGSAMSFGKSPARLLAKGQNKVTFADVAGIEEAKEELVEIVDFLKNPTKFTSLGGRIPKGILLIGAPGTGKTLIAKAVAGEADRPFFSIAGSDFVEMFVGVGASRIRDMFEQAKRNAPCIIFIDEIDAVGRHRGAGIGGGHDEREQTLNQLLVEMDGFGTNEGVILMAATNRPDVLDKALLRPGRFDRRVVVNLPDIKGRFEILAVHAKRIKLDPTVDLMAVARSTPGASGADLENLLNEAALLAARKDRTAVTAVEVAEARDKVLYGKERRSLEMDAQEKKTTAYHESGHAIVGLCVEHSDPVDKVTIIPRGLSLGATHFLPEKNKLSYWKKELYDQLAVLMGGRAAEQIFLGDVSSGAQQDIAQATKIVRSMICEWGMSDHLGTVAYDERSEAAPTGYGSCHEKNYSEETAKAIDNELKTLLDAAYQRALDIINSHKEELELMTQMLIEFETLDSKDVKEIMDHSWDADKKQARMKEEGMLYKKISEDLPPPPPQENVQDGTSLKFNTST
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MAGYPPNPGSGYPYGGAGGYGAPPPPYGSSPAPSAPPYGAKPPKEGKTSSSSAPYYGGGGGYGAPPSTQPYGSGGGYGAPPSSQPYGAPYGAPPPSSAPYGAPGGYGSPFASLVPSAFPPGTDPNVVACFQAADRDGSGMIDDKELQSALSGYSQSFSLRTVHLLMYLFTNTNVRKIGPKEFTSVFYSLQNWRSIFERFDRDRSGKIDATELRDALLSLGYSVSPTVLDLLVSKFDKTGGKNKAIEYDNFIECCLTVKGLTEKFKEKDTAFSGSATFTYEAFMLTVLPFLIA
The following text describes a protein:
Function:
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes.
Subcellular Localization:
Nucleus.
Sequence:
MVDDSHNAPFDKTKFDEVLEALVGLKDNEGNPFDDIFEELPSKRYFPDYYQIIQKPICYKMMRNKAKTGKYLSMGDFYDDIRLMVSNAQTYNMPGSLVYECSVLIANTANSLESKDGTLNEEENEEMESSINEEHKPGTNEIDVPKVIQNILDALHEEKDEQGRFLIDIFIDLPSKRLYPDYYEIIKSPMTIKMLEKRFKKGEYTTLESFVKDLNQMFINAKTYNAPGSFVYEDAEKLSQLSSSLISSFSEQPKEHSPATSKHEPEETPASPTPSVSASTSRERSTSVAPSFITSDQAATPDVLKSEEAHVESFSKESEKDQTPIPEDVPSPMDTLSQANYGAFALIKSFPSTPVPDFLNFSHKSVMGRSTFNMPNFPEPKFFEDIPNTERCILSAFICSPPQLPLPNPLRMYLPCPSLNSTEVSVITLAPQHSFLNIVINLNPALALKSYTIITLLNGKRLGAGVSTPPSTLYALEGIKHTEEPIRTVYEAKLSVGLNCLEFVLGSTEPVEPPSIEPGLPASAYSRTVERERFVLMAYVQP
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Subcellular Localization:
Nucleus.
Sequence:
MASNNKNNSDKIDDGDCDSEIGSVKKLLEKLQKYSAMDKLIKKDEKKILKVLQKLESCNMTVEILKKTKVGLQVNQLKKKTDNTAIKTQAKSVVERWMKIFDASTAKRKEDKKAGKSSSGVAKTQPPPSPSTPSPPLLPPSPATPTLPSPPSAPSANLEKKPTKSPVSSSAVAAAAALNPSSSSQLSSQSSSSESTLVRSSSSSSKRLKIDDGHFHTDDPVRVSTRNMLFNALRSEGDDESDIQQLAAEIESCIFDEMKDTGTKYKNRIRSRTFNIKDPKNPQLKEKILNGLITPQRLAVMTSTEMASDELKNLRENFTKKAIHEAQAPSIAAAKSDLFRCSKCGKRDTTYNQVQTLSGDEPMTTFVVCNQCGNRWRFS
The following text describes a protein:
Function:
Stabilizes the expansion of the capsid head shell after genome packaging. The packaging of viral genome in the procapsid triggers a dramatic reconfiguration of the capsid shell, expanding from roughly 50nm to 60nm while the capsid thickness decreases. 415 capsid decoration protein molecules cooperatively bind the expanded capsid, thereby stabilizing the mature capsid shell.
Subcellular Localization:
Virion. Host cytoplasm.
Sequence:
MTSKETFTHYQPQGNSDPAHTATAPGGLSAKAPAMTPLMLDTSSRKLVAWDGTTDGAAVGILAVAADQTSTTLTFYKSGTFRYEDVLWPEAASDETKKRTAFAGTAISIV
The following text describes a protein:
Function:
Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.
Subcellular Localization:
Secreted.
Sequence:
MWAWGWAAAALLWLQTAGVRARQELKKPRQLVVRVDSPNITTSSHEGFPGSIKPPEASGPELSDAHMTWLNFVRRPDDGASRKRCRGRDKKSRGLSGLPGPPGPPGPPGPPGSPGLEVTPEALLQEFQEMLKEAAELRFSGIPDSLLPQEPRQRLVVEAFHCRLKGPVTVDKKTLVELQGFQAPTTQGAFLRGSGLSLSLGRFTAPVSAIFQFSASLHVDHSELQGRGRLRTRDTVRVLICIESLCHRHTSLEAVSGLESNSRVFTVQVQGLLYLQSGQYVSVFVDNSSGAVLTIQNGSSFSGMLLGT
The following text describes a protein:
Function:
May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Sequence:
MPVIDNVEDLMAWLAKKLEPICDADPNALAKYVVALTKKDKTNEELRATCIDQLGVFLVNETQSFVDNLFVALATKSYIPGGSANITAVEGGKQDPPPPQPAALAPGGADLPTSAETSTKEEVRSRSSNRDVTGENDEQRDHRRSGRRHSRSHSRSKSKSHSPRNRSRSRSFSPRRRRRDEDRRRRDDRPDRFGGPRRYGDRDRDRDRDRDRNRDNRDFRDRDRERDRMRGRDGRDPGRFDDRGRIRDRDLDRERDDRLKENNSKPMAISSVITVVSNDGPEPAQGPPKQGEKQQQQQQPLQRIRQRCRDYDEKGFCMKGEFCPYDHGNDPVVVEDIDMFRPPPNMDASRPPVPSLPPAPQPPLPPLPPSQPPPPLLPPFGMPPPGFVPTPGMPLPPPPPMHPPPGRMHGPPRHNGPPPGPPPGLPPHMRLPPPPTSGPPPPLPPMPLQMNRPPPPLPPAPDANMPPSVPQPPSSPPRESSPPPPPSETKPYGSSQDFQMEGYNPEDPSMEAQGGRQYFGGGRAPRQASSNLRTLVGIQTVPTTTKEEMEEIGALTKDSSSSDDNQSERKVVDLTKGQDGLGLGVQEEQRRAVIKSNDRPLGLGYPPPKRPYNHGGGGGGAVDLRARIGGKGKGRFVPNNRILEVRKIPREFNNITKLNEHFSKFGNIVNLQVAYAQDLEAALVTFTTHLEAKKAYQSTEAVFNNRFVKVFWHVPPENTAGEDEPNHHTRKPAKQRIQLPTKKQLTVVRNHATPSDKVVIQPGGNSTLTKTIMNPKAVAINQRLVTVQNNLANAKKAAAAHTSATVAKKLAAAQEAVRKKQEEAKKLVAKKQTEIFKQKQELMNGFIQQQKMLITKLEQGKSTMTTLKRAEIMKSIKMLSENIEKTKKELTDAKPKTKDKKQAERELLDTELDLYNQQSEGGDTSDLRKRVDELRREAQALGLLDNTVGSSRGRGHPRSIRGRGRGRGRGFMAARRRSSNTNLVVDKRPRGLVVGGFAPGDKDEVLVHFTNFGEIDSVEYNEDSATYVLEFKTRQEAEMAVAKGNQFKGDSLSLAWHKQQDPVAEMVEDTMDVGEELADEEEEEMEEELEDDLLLVDDEEEEDDEEGRSWKR
The following text describes a protein:
Function:
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Sequence:
MPKTLTEKLNAIKATGKGIFVPYIMAGDHEKGLDGLGETIHFLEDLGVSAIEVGIPFSDPVADGPVIEEAGLRSLAHGTSTQALVETLKTIETEIPLVIMTYFNPLFQYGVENFVKDLADTAVKGLIIPDLPHEHANFVEPFLADTDIALIPLVSLTTGIERQKELIEGAEGFVYAVAINGVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQADLERFNAVSDGVIVGSKIVKALHQGEPIQDFIRQAVAYQK
The following text describes a protein:
Function:
Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. Transcription factor that binds to the GCC-box pathogenesis-related promoter element. Acts as a transcriptional inhibitor and may regulate other AtERFs (By similarity).
Subcellular Localization:
Nucleus.
Domain:
Contains a slightly degenerated ERF-associated amphiphilic repression (EAR) motif, which may be involved in the activity of transcriptional repression.
Sequence:
MAPTVKTAAVKTNEGNGVRYRGVRKRPWGRYAAEIRDPFKKSRVWLGTFDTPEEAARAYDKRAIEFRGAKAKTNFPCYNINAHCLSLTQSLSQSSTVESSFPNLNLGSDSVSSRFPFPKIQVKAGMMVFDERSESDSSSVVMDVVRYEGRRVVLDLDLNFPPPPEN
The following text describes a protein:
Function:
Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MEWVKHKDFPEEMTANAQNLDSALSEMEAVVNALTSVPLTEVQSCLKPIERSKYDTASVYAVTSLFWAYMKTRGVDPKTNGLPRELERVKSAIGRSKEIVDRALAPKVDISAAKRFIRGGLWEPKDSEQREGSNQEKSDVSKPPPNKRIRFDDAGSTELTNNAEK
The following text describes a protein:
Function:
Protein that inhibits host translation while promoting late viral translation by ribosome shunting. Blocks host cap-dependent translation by binding to eIF4G, displacing MKNK1 from cap initiation complexes and preventing EIF4E phosphorylation. Binds to the tripartite leader sequence of viral late mRNAs and recruits host eIF4G, PABPC1/poly-A binding protein and 40S ribosomes subunits on viral mRNAs, allowing ribosome shunting and efficient translation of late viral mRNAs even though conventional translation via ribosome scanning from the cap has been shut off in the host cell. During assembly, acts as a chaperone protein that helps hexon proteins assembly into trimers.
Miscellaneous:
MISCELLANEOUS: All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Subcellular Localization:
Host cytoplasm.
Sequence:
MSEEPVSGTTVEIEEDTHTPPNSPVLETFSLSPEPEAEACPNTDRYLSANLLCKHLQRQSAIVLDSIKDQLQVPTSVSELSCAYERSLLCPNIPPKQQSNGTCEANPKLNFYPTFLVPETLATYHIFFVNQKIPVSCKANRAKADKALTLQEGDCLPDYETMDTVSRVFEGLGGEVVAENALQNNDSVLVELKEDNPRLAVLKRNLSVSHFAYPAVHLPPKIITTVMNNLLVKRANPSADVSELDPDGGQEVVSDTELSRWLNTSDPETLEKQRKLVMGSVLVTVVLECMQRLFTSKDMVKKIGETLHYTFRHGYVSLACKISNVELTNVVTYMGILHENRLGQTTLHHTIQGETRRDYIRDSIFLILIHTWQTAMGIWQQCLEEENLKELAKLVQKIKKPLYTETSQRLMGKQLANVVFPPKLLETFNKGLPDIVNQSMMQNFRSFILERSGILPSMTCALPTDFIPIHFKECPPTMWPYTYLLRLANFFMYHNDLCYDMEGEGLLEHYCRCNLCTPHRCLATNPAMLNETQLIGTFDIRGPGGENGAESSSGLKLTAGMWTSAFLRKFESSDYHAHKIHFYENQSKPPSVEPTPCVITQSSILAQLHDIKKAREEFLLKKGQGQYLDPHTGEPLNAAGPSVESGHEFQGDGRHREPKRGRHFRQRGGPRKPPRAHAGGEPDVRGTTS
The following text describes a protein:
Function:
Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.
Subcellular Localization:
Membrane.
Sequence:
MRSSTLSASAVLLLSGLASAQTFTDCDPTKKNPAIGGIQVTDFTAGKSSNWEDEAGTTMSYDPQLGAKFVISKGTDAPTIKNIGYLMFGRIETWIRASPGTGIVSSFILESDDLDEIDWEWLGYDNTSAENNFFGKGNTTTYNRAQYPPVATPMDVFHNYTIDWTAAATVWYIDGVAVRTLAYDDPLTIGGKNYPQTPMLVKMGSWIGCLDQAAVTNPATAGTCSWAGGAADLTKGPYTMYVKNVTIEDYGCATEYTYGDLSGSYQSIKATGGCSKDGKSTLSSSSSSSSSASSSASGKSSSGSSTKTASGTASGTATGIQTATASAGVKATGTASASASASGSTSGSSTLTQVSTSDSNSIKKPKHEYGMLDLGVMALGLGLGYLVM
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MEEEGTLVRADNLKHAGTPSPSKFSPYSLYFKGLVSEESPKLSAEFRVAICGYKDGLMFQMKGPIHDSAITLLEAELMALKYGLSEAVTLGINHISICCDNNQIFEWVMGRSTPQEENIAMLIRDVQGIRKQFTSSIAVLIDVPALFHPKKTCTICFDDDINADMMFYIDQCGHMFCSECVKRHIEVSLLQGSLITCPSYRCKSKLTYGSCVNILTPKVKEMWIQRMGEDSIPVTDRVYCPNPTCSALMSVTELDQLTGSKRCCVKCGESFCIKCKVPWHDNLSCKRYKKLHSNRTTNDKQLNELANQESWRQCSKCKHMIELTQGCVRVICRCGHEFCYGCGADAGCCSHGHVPYFSVERREPEVQALVLIGVVVVTMIFFFR
The following text describes a protein:
Function:
Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
Miscellaneous:
MISCELLANEOUS: Is not encoded in all strains, and seems to be dispensable for replication.
Subcellular Localization:
Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.
Sequence:
MGQEQDTPWILSTGHISTQKGEDGQQTPKLEHRNSTRLMGHCQKTMNQVVMPKQIVYWKQWPSLRNPILVSLKTRVLKRWRLFSKHEWTS
The following text describes a protein:
Function:
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
Subcellular Localization:
Cytoplasm.
Sequence:
MHLDSGSDSGTDSGSDSSSDSSTNFTADSSHDSSSDSDSDSQRPPPLSNTKIKSMLEIMVGVQPQVIIDIKELQSFVDRNYLIKINYSGMLESAFAADNTSADEESSTIVQDNASQRYVLKILNSSDSRNINTALARLHAMKYLYSLGIKCCNPMTLLDGELTLKLHLPVQEVDDADDRETTREYIAYLMNYVEGEILSKVEPNLDIFCKVGKYAAVLDGHLQSFSDDHLKNYHEVPNLRTAVIHNDLNDDNLLIKLNTHTNSYDIAGVIDFGDVDHTTLIFELAILIIHMMVTCNDNPIELAGHIISSYHSVLPLTKVEYNGLYMVALARLVQVIVLSEYEHKHSPDNDYVMYQYDAFWSLLSIIWDECARICYVNELQKSSFVEKLRCNLIIFQAPYILVFGDKLRD
The following text describes a protein:
Function:
Important role in neural and renal epithelial function.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MHCLVILGFLLGSLVAFSWAGVTTQPPPLIRTLSAGGDIGPQFDVGKTKEPEDAEFWHNVGLRQLEKTIKQAQRVKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQYLKHGYGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDATRSKKNGQQGRVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAESVGFHVDIARQLVENAPGNRFNVILGGGMSPMGILNASEVKTTIFEGPTETICTRGDNRNLPAEWLAHHANDTVPPALVHNRKDLLNVNVKKVDHLMGLFRNNHITYSIAREAGEPSLQEMTETALGILERGDESNGFVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYALRGADILGTANSHEKNDPMFYETISYANGPGYWDHLANDSRPQNSSNMWMPLKHFTAEERAAPTYRHLATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGPAKDFDDSCEDHKDGQKDRPLDKPNPKRNGATVVGASLIPILTAATAAILRGRGL
The following text describes a protein:
Function:
The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MESFVLFLPFLLIMGGFMYFASRRQRRAMQATIDLHDSLQPGERVHTTSGLEATIVAIADDTIDLEIAPGVVTTWMKLAIRDRILPDDDIDEELNEDLDKDVDDVAGERRVTNDS
The following text describes a protein:
Function:
RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.
Sequence:
MSSSSSSPRETYEEDREYESQAKRLKTEEGEIDYSAEEGENRREATPRGGGDGGGGGRSFSQPEAGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEFESVLCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQAILGEHPSSFRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGNPSGSVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLTFIKYKVFDAKPSAKTLSGLLEWECKTDAVEALTALNHYQIRVPNGSNPYTLKLCFSTSSHL