lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Receptor tyrosine kinase required for larval development. May phosphorylate adapter protein soc-1 which in turn may result in the recruitment and/or activation of phosphatase ptp-2. May activate the Ras/MAPK kinase signaling pathway which includes sem-5, sos-1, let-60/Ras, lin-45/Raf, mek-2 and mpk-1. Acts in the hypodermis to regulate axon growth and fluid homeostasis. Activates protein degradation in muscles. Probably following interaction with ligand let-756, negatively regulates membrane protrusion from body wall muscles during larval development. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine. Regulates synaptic levels of nAChR subunit lev-1 in the nerve cord; [Isoform b]: Affects the maintenance of axon position without affecting axon growth. Interaction with egl-17 is required for the guidance of sex myoblast migration during gonad development; [Isoform a]: Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures; [Isoform c]: Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures; [Isoform d]: Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures; [Isoform e]: Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MSYFLASCLGVGLLSTVSCSLQGLTSHYRENIPRFKHVANERYEVFLGDEIKFDCQTAASKISAFVEWYRNDKLLKNDQIDKDKIRKDNNRMMLHLKNIDVSDQGLWSCRVHNAYGQISRNFTVEVIDFCDYFLFPDIHHLNIPMECVCLWKYNKEAKRSDVNYAAVTGEVCSKYASRMINRARKPLPMIPCFGDHCKEFDTTPVSDFGLPGKPEDDPLVKRVVLKKDDVIVPVHDSEESPSESRTEFINADEKENKEDEEEDYSVSQPVAPDAGLTELNITAEEPPYFKSNDNIVLFNETHALPAGRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGGYEFKFNRWSLEVEDAVVADSGEFHCEALNKVGSAKKYFHVIIVNRMRRPPIIVPNILANQSVNINDTATFHCKVVSDLLPHIIWVRINKINGSYSYYNNSAEEYMFNYTEMDTFDKAHVHHVGDESTLTIFNVSLDDQGIYACLSGNSLGMSMANATLTVNEFMAIHLLTGDEPKIDRWTTSDYIFTTILLFLLLAATLFGILFMVCKQTLHKKGFMDDTVGLVARKKRVVVSKRPMNEDNENSDDEPSPYQIQIIETPITKKEAARKQRKRMNSENTVLSEYEVDSDPVWEVERSKLSLVHMLGEGAFGEVWKATYKETENNEIAVAVKKLKMSAHEKELIDLVSEMETFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSSQELTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPYPTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYLDWMLTMTNETIEGSQEFNDQFFSERSTASGPVSPMESFQKKRKHRPLSAPVNLPSEPQHTICDDYESNFSVEPPNDPNHLYCNDNMLKNHIITPETSQRIPSNNNSMSKPEF
The following text describes a protein:
Function:
Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
Sequence:
MAALNLSDQRQSPDDVLASGEYPLTRRDLSEIAAMIYADAGIYLNDTKASLVYSRLSKHIRNLGLSGFREYCALVSSSEGAQPRREMLSHLTTNFTRFFRENHHFEHLRDEVLPGLIARAKSGGRVRIWSAACSDGQEPYSIALTVLAMFPNAADYDFKILATDIDPKILAQARAGVYDDNALETVSPAMRKQWFTEVDAGGRRKFRIDDKVKRLITFNELNLMTQWPFKGNFDVIFCRNVVIYFDEPTQVRIWSRFAGLLPEGGHLYIGHSERVSGDAKNVFDNTGITTYRFIGHASGRKA
The following text describes a protein:
Function:
Oxidizes aldehydes to the corresponding carboxylic acids with a preference for aromatic aldehydes. It might play a role in the detoxification of aldehydes to avoid cell damage.
Subcellular Localization:
Periplasm.
Sequence:
MKFDKPAGENPIDQLKVVGRPHDRIDGPLKTTGTARYAYEWHEEAPNAAYGYIVGSAIAKGRLTALDTDAAQKAPGVLAVITASNAGALGKGDKNTARLLGGPTIEHYHQAIALVVAETFEQARAAASLVQAHYRRNKGAYSLADEKQAVNQPPEDTPDKNVGDFDGAFTSAAVKIDATYTTPDQSHMAMEPHASMAVWDGNKLTLWTSNQMIDWCRTDLAKTLKVPVENVRIISPYIGGGFGGKLFLRSDALLAALAARAVKRPVKVMLPRPSIPNNTTHRPATLQHLRIGADQSGKITAISHESWSGNLPGGTPETAVQQSELLYAGANRHTGLRLATLDLPEGNAMRAPGEAPGLMALEIAIDELAEKAGIDPVEFRILNDTQVDPADPTRCFSRRQLIECLRTGADKFGWKQRNATPGQVRDGEWLVGHGVAAGFRNNLLEKSGARVHLEQNGTVTVETDMTDIGTGSYTILAQTAAEMLGVPLEQVAVHLGDSSFPVSAGSGGQWGANTSTSGVYAACMKLREMIASAVGFDPEQSQFADGKITNGTRSATLHEATAGGRLTAEESIEFGTLSKEYQQSTFAGHFVEVGVHSATGEVRVRRMLAVCAAGRILNPKTARSQVIGAMTMGMGAALMEELAVDDRLGYFVNHDMAGYEVPVHADIPKQEVIFLDDTDPISSPMKAKGVGELGLCGVSAAIANAVYNATGIRVRDYPITLDKLLDKLPDVV
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Domain:
The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
Sequence:
MNTTMNSQPSDECAICYQKMVLPLMLTCNHSFCFLCIKGVHETMNPPLCPMCRDDISPDLFKKPRQVGKIDMKDPEDSPRRQSAGPTVKQDPGSHVQITRDAQGNIVAQTSSTPVVKTDPDQAKSYWLYQSGSDRWWRFDPRCEKDLDEKRAAGERQFDMMIVGHSYRIDLDRMTQMRLDRLGGQPIGNGRHRELLHVESVEELKALDVRGIAGVILTTN
The following text describes a protein:
Function:
Effector that is released into the host cell and affects host immune responses; it negatively modulates inflammation, macrophage autophagy, and cell death through redox-dependent signaling. Acts as an acetyltransferase. Acetylates 'Lys-55' of dual-specificity protein phosphatase 16 (DUSP16)/mitogen-activated protein kinase phosphatase-7 (MKP-7), a JNK-specific phosphatase; this leads to the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS (reactive oxygen species) generation for enhanced intracellular survival of M.tuberculosis. Inhibits Con A-mediated T-cell proliferation in vitro. Treatment of T-cells with Eis inhibits ERK1/2, JAK pathway, and subsequent production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-4 (IL-4); on the contrary, there is increased production of interferon-gamma (IFN-gamma) and interleukin-10 (IL-10), which indicates that immunity in response to Eis treatment is skewed away from a protective T(H)1 response and Eis disturbs the cross regulation of T-cells. When expressed in M.smegmatis, enhances intracellular survival of the bacteria in host macrophages during infection; Can also acetylate multiple amine groups of many aminoglycoside (AG) antibiotics, leading to their inactivation, and thus contributes to drug resistance. Is also able to acetylate and deactivate the cyclic peptide antibiotic capreomycin, but not the other anti-tuberculous drugs isoniazid and pyrazinamide. Acetylates kanamycin (KAN) more efficiently than amikacin (AMK), even though Eis seems to bind AMK with higher affinity. Does not acetylate and inactivate streptomycin, apramycin and spectinomycin; Acetylates DNA-binding protein HupB.
Miscellaneous:
MISCELLANEOUS: Increased expression of eis due to point mutations in the promoter region of eis is responsible for resistance to the second-line injectable drug kanamycin in a number of M.tuberculosis clinical isolates, through acetylation of its amino groups, which leads to inactivation of the drug.
Subcellular Localization:
Secreted. Host cytoplasmic vesicle, host phagosome. Extracellular vesicle, bacterial extracellular vesicle. Host extracellular space. Note=Eis is present in the macrophage cytoplasm from 4 to 96 hours post-infection.
Domain:
The Eis monomer consists of three regions that are assembled into a heart-shaped molecule. This shape is formed by an unusual fusion of two general control non-derepressible 5 (GCN5)-related N-acetyltransferase (GNAT) regions and a C-terminal region. The N-acetyltransferase domain of Eis is responsible for its modulation of ROS generation and pro-inflammatory responses in macrophages.
Sequence:
MTVTLCSPTEDDWPGMFLLAAASFTDFIGPESATAWRTLVPTDGAVVVRDGAGPGSEVVGMALYMDLRLTVPGEVVLPTAGLSFVAVAPTHRRRGLLRAMCAELHRRIADSGYPVAALHASEGGIYGRFGYGPATTLHELTVDRRFARFHADAPGGGLGGSSVRLVRPTEHRGEFEAIYERWRQQVPGGLLRPQVLWDELLAECKAAPGGDRESFALLHPDGYALYRVDRTDLKLARVSELRAVTADAHCALWRALIGLDSMERISIITHPQDPLPHLLTDTRLARTTWRQDGLWLRIMNVPAALEARGYAHEVGEFSTVLEVSDGGRFALKIGDGRARCTPTDAAAEIEMDRDVLGSLYLGAHRASTLAAANRLRTKDSQLLRRLDAAFASDVPVQTAFEF
The following text describes a protein:
Function:
Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere, Z line. Nucleus.
Sequence:
MQDNTSEPSTSITQLLRESYLAENSHQGNSERSRSEPSPHSFHCGDTSGTSDEVPGQDDLPDLSAFLSQEELDQSVNLARQAISQDPLESKPDEQVHVFYPSELKNSGNTVSKKPQFQPSSSPTLDSSQKKQTSSSEAESKKEFLNKAADFIEELSSLFKAHNSKRIRPRTCKNYKSKLESKNKAAQESSCAFSNLSENRERPCAPVTQDLDKTEHTLEQPDKLLQADLEAVTTLEISGLTTESPAASFNSDEPLGQPPHFTQKLKSREVLEGTKVQLDCIVVGIPTPEIRWYCEGKELENSPDIQIIQSGDLHSLTIVEAFEEDTGRYSCFASNIYGTDSTSAEIFVEGASSSESEPDSSKEEMDQYQTHRKVSSDVPPPPVNTIVSHQESPKPQPSIIQPVSIPVHCQSPTNYLQGLDGRPIIAAPVFTKMLQNISASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMSEPEEICTLVIAEVFSEDSGSFTCTASNKYGTVSSSAHLTVKGPEDQNNNAVLHSVSSISLFAAEHTPSAPVPSLPLVDHTPKPKLEGVLINHNEPRSSSKAGLHVHFKLPEDDKGSEASSEDGGGPGNQIRPNSFPDKLNGQIFKIQEPTSPSKEPPPVLAKPKLDPTQLKQLHNQVMLEQQQIQQPSPPPPRETLFNFATPNFSPLPNQQQQSPPPPSSAAYKQNKAPPTQAFNYTRPKQFLSSQSSLAAVSSPSSSPMPSFTNVSQGTQRTANKESFLGSPPPSQTKSSGGMMNQTEQLLTSPKETVLPPLLLSVSSTNQFQPQNVPSTPLSPTGRIQNPVAFLSSVLPSLPSTPPKNAMGLPKSAPAVGNQGTVKRNHRTSHLATEDSIRDHKATVVKDLEKRLHQRDDVFSQSLQRTNYDENLACRLQGPSNDATTFNFTAQDVSKEYKISSFEQRLMNEIEFRLERTPVDESDDEIEHDEIPTGKCIAPIFDKRLKHFRVLEGYPAAFTCKIVGIPIPKVYWFKDGKQISKRNEHFQMNREGDGTCSLHIETTTNDDDGNYTIMAANPQGRISCSGHLMVQTPPLRGRLTTAEQSHRGRSRIPEGDKEPLQERFFRPYFLQAPGDMVAHEGRLCRLDCKVSGLPPPELMWLLNGRPILPDITHKMLVRETGVHSLLIDPLTRNDAGTYTCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPPNRERTSMHQDATGYVCLLIQPAKKVDAGWYTLSAKNEVGIVSCTARLDIYAQWHQQIPQPIKIRPGGTRYASLSGQGLDIFSAFSPVETPVRFSSPPQPVVESEEL
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MVQEEIRRGPWTEQEDLQLVFYVKLFGDRRWDFLAKVSGLKRTGKSCRLRWVNYLNPDLKRGKMTPQEERLVLELHSKWGNRWSRIARKIPGRTDNEIKNYWRTHMRKKAQEQRKKATSISPSSSFSNCSSSSSITNEENERNFYDTGGIELLQIEEQKKANDQEQAGESTKVYSMDEIWKDIELLEENETINKPIMGSISPLWDYCPDPMWKDFDWSNFR
The following text describes a protein:
Function:
Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
Sequence:
KTESTQTCFDCICTSFVKFFVFLFFLVTFPISGFFCLKIAHQYERIIIYRLGRLIPIKGPGVVLVLPCIDHWKKVDMRTKAFNVPPSKLCTSDGCIISIGAIVHFSIQDPRLMSLSVQNMNHSIRDASQGCMMNLLCKKTYNDIKTKRQGLSYDLQVDINQSAKEWGLAVSRVELSDITLIMAPQNKTPAFMPMYGAPPPPETGDAFTGSGVDNFGGIAQFATQLFAQVANAQSQQANDAEPPTSSTMDNLLRVLKTAVNEELVQEVDTLYQFNITGIQDGNFFADLRTGSGVVGLGVCSESPDVTFSLSMSTLQKIIAGSVTPYNAYIGGQLHMDGDTDKAMKLEKVVKDIK
The following text describes a protein:
Function:
Probable transcription factor that forms heterodimers with the MADS-box proteins AGL66 and AGL104 and is involved in the regulation of pollen maturation at the late stages of pollen development and pollen tube growth.
Subcellular Localization:
Nucleus.
Sequence:
MGRVKLKIKKLENTNGRQSTFAKRKNGILKKANELSILCDIDIVLLMFSPTGKAAICCGTRSSMEEVIAKFSQVTPQERTKRKFESLENLKKTFQKLDHDVNIREFIASSNSTVEDLSTQARILQARISEIHGRLSYWTEPDKINNVEHLGQLEISIRQSLDQLRAHKEHFGQQQQAMQIENANFVKDWSTCSMQDGIQIPLEQQLQSMSWILNSNTTNIVTEEHNSIPQREVECSASSSFGSYPGYFGTGKSPEMTIPGQETSFLDELNTGQLKQDTSSQQQFTNNNNITAYNPNLHNDMNHHQTLPPPPLPLTLPHAQVYIPMNQREYHMNGFFEAPPPDSSAYNDNTNQTRFGSSSSSLPCSISMFDEYLFSQVTKTKLSQRF
The following text describes a protein:
Function:
Aspartic proteinase.
Subcellular Localization:
Secreted.
Sequence:
MHLIFLLFLAPFCSAAVFQLPTKSTGSLRAKLIRAGKYQEFLITQHAARLNTISQPISDYSDEVYLGNFTVGTPPQPVSLVLDTGSANMWVIDASCDNMFCNGWIGSNYTRQKFDTSKSSSFSRENRKFSIQYGKGLCSGYLGTDTVGLGGGLTIRKQELGIANKLDVDFAVQPMDGIFGLAWPALAVDQITPPMQNLISQLDVPVFSVWLDRKIQASHGGSAGMITYGGIDTKNCDAGVTYVPLTAKTYWQFKMDGFAVGTYSQYGYNQVISDTGSSWISAPYAMINDIATQTHATWDEMNEIYTVKCSTMKTQPDLVFTIGGALFPVKSVEYILDIGLDEGKCALAISPLMASGFGPSWILGDVFIRQYCNIYDIGNARIGFANAHHSF
The following text describes a protein:
Function:
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MPPKKGVSAAEKRDRVLEIFHESSDVFQGKDIEKLATKKGVISQAVKDVLQSLVDDNLVHMEKIGISNYYWAFPSEASVMVENDVKRLETDLAATRKRRAEVEASLEQHKAANPDTESRAQALAELNKLKKRATEVSFKLEAYRDNDPETVQAMHNIAESCKLAANRWLDNTYSLLSWCKKRFAGNEAELAKFFEEVRARPLAPRVQNTWAAS
The following text describes a protein:
Function:
Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
Sequence:
MFTSEEYLPTKPLDSPITITNKSAKFAAFKVWSKYPDLFRADPQCGIIPAGGTQTVNINYQNPVKPTVEYYVRVFAALVDKEVLPEEFRAEKTATPKNYDGENFLPVQFRRAAAITPLPKEVVIIPGDKIPLNFECKPIGAEPAYSVMTITNNHPQKNLTGSVIPTGSQIFNVKWRSGVLRPGKSAHLPCMFTNLKEEKEEHWFLTFVVFIDSTTLPDDFRKRIAPPFVYDGARAIEITFSKSTSTEPSPYHLKWQALFTKKATVPSAEKAASAEKTEDGGGPPSQTGAPTVTDADNPAPVPAPVPVPAAAPTTTAA
The following text describes a protein:
Function:
Regulatory protein of the TOL plasmid xyl operons. XylS activates the xylXYZLTEGFJQKIH operon required for the degradation of toluene, m-xylene and p-xylene.
Subcellular Localization:
Cytoplasm.
Sequence:
MHTLSSAHNSFEAWNQALRQVCGRFESQPALNRTLFIGDISRQDLGGLELAQIRTNAGRIARQATHADHDDDRHCFLVVQRSGHAQLRQGGDSIELAPGEMALMDSAGGCEIIPHGLIEHTSFHLSREEVCRHLPPSQRAFGKLSPNCASGRLLSLLVQQVCAGELQPWAVADEGGALQEALIALLGPALQHAGEELEGPLAGLYGYSLRRHAERLIEQSLQEPRLSPDMLAGRLRISVRQLYRLFEEQGDSVCRYILRQRLSRSAADLGNPRLRGESITSIAFKWGFSDSAHFSRAFKKQFEVSPKDYRAGALPA
The following text describes a protein:
Function:
Transcriptional repressor. Direct regulator of the transcription of peroxidase (Prxs) and reactive oxygen species (ROS)-related genes via the recognition of 5'-ATCACA-3' motif. Binds to 5'-TATCCA-3' motif (TA box) and represses the activity of corresponding promoters (e.g. sugar response genes). Regulates hypocotyl elongation in response to darkness by enhancing auxin accumulation in a phytochrome-interacting factor (PIF) proteins-dependent manner. Promotes lateral roots formation. Promotes cell expansion during leaves development via the modulation of cell wall-located Prxs. Plays a critical role in developmentally regulated and dark-induced onset of leaf senescence by repressing the transcription of several genes involved in chloroplast function and responses to light and auxin. Promotes responses to auxin, abscisic acid (ABA), and ethylene.
Miscellaneous:
MISCELLANEOUS: 'Kuoda' means 'enlarge' or 'expand' in Chinese.
Subcellular Localization:
Nucleus.
Domain:
Contains a R/KLFGV repression motif, which may be involved in the activity of transcriptional repression.
Sequence:
MTRRCSHCNHNGHNSRTCPNRGVKLFGVRLTEGSIRKSASMGNLSHYTGSGSGGHGTGSNTPGSPGDVPDHVAGDGYASEDFVAGSSSSRERKKGTPWTEEEHRMFLLGLQKLGKGDWRGISRNYVTTRTPTQVASHAQKYFIRQSNVSRRKRRSSLFDMVPDEVGDIPMDLQEPEEDNIPVETEMQGADSIHQTLAPSSLHAPSILEIEECESMDSTNSTTGEPTATAAAASSSSRLEETTQLQSQLQPQPQLPGSFPILYPTYFSPYYPFPFPIWPAGYVPEPPKKEETHEILRPTAVHSKAPINVDELLGMSKLSLAESNKHGESDQSLSLKLGGGSSSRQSAFHPNPSSDSSDIKSVIHAL
The following text describes a protein:
Function:
Lignin degradation and detoxification of lignin-derived products.
Sequence:
MRFLPLLGGLLPLLGLVGAAPSCNHECNRACWTSRFNVNTDYENEWPVTGVTRKFDFEITEVDEWVGPDGHIKKGAMLINGGYPGPLIKADWGDRIEVTVTNKLKTNGTSMHWHGFHQLNSNNQDGVAGVTECLIVPGASKVYSFLATQHGTSWYHSHISSQYANGIVGPIQINGPSSYPYDTDLGVFPISDWYYDSAEHIVDRMMDPNDPFLKGVPGSPPPSNNILFNGMNIAPNGTGGEYARLKFTKNKRHRLRLVNTSADNTFVVSIVGHNMTVIETDFVPVEPYAVHQLYLTVGQRYDVVIKADQEVDNYWINATLSSTPLCGVSLNPYPAAIVSYEGSDESRLPTNRGPRAIDQFCEDDVSSKPLTSRTAPKADFSDTKVDTLSVTLDVKEVNKGISKVLWSVDGSAIDVQWDKPTLEYVVEGNFTFPRQANIIQLPEAVKWSFWVIQNNSPSPHPMHLHGHDFLILGRSRFPANPLVDPGQPILFDPVVDGPHLKFDNPTRRDTTVVPSFGWLVIAFEAGRNPGSWVFHCHIPWHMSQGLSVQFLERVDRINDGAIPNLMPDLQEKCDEWRRYADNDPEFRMKKVDSGI
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MEKSPAMHFLLELESQEPVCLLILFTMFTWFISKVQMILPSSCQHCNYAVTKVTSTPVLADRKISKNLSKHKDDGIEMTHEDVESVMTKMGPDFDHGKTMVYKEIGSNCMSELFDDDEPSLDEVKQAFLVFDEDNDGYIDALDLYRVLRNLGLREGVGVDECEQMIAKYDMNRDRRIDMVEFIRVLEASFF
The following text describes a protein:
Function:
Function prior to stable branch point recognition by the U1 snRNP particle to facilitate or stabilize the U1 snRNP/5'-splice site interaction. Has a direct role in the assembly or function of a catalytically active spliceosome.
Miscellaneous:
MISCELLANEOUS: Present with 4460 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MPDETNFTIEDIEPRPDALRGLDTQFLQDNTALVQAYRGLDWSDISSLTQMVDVIEQTVVKYGNPNDSIKLALETILWQILRKYPLLFGFWKRFATIEYQLFGLKKSIAVLATSVKWFPTSLELWCDYLNVLCVNNPNETDFIRNNFEIAKDLIGKQFLSHPFWDKFIEFEVGQKNWHNVQRIYEYIIEVPLHQYARFFTSYKKFLNEKNLKTTRNIDIVLRKTQTTVNEIWQFESKIKQPFFNLGQVLNDDLENWSRYLKFVTDPSKSLDKEFVMSVFDRCLIPCLYHENTWMMYIKWLTKKNISDEVVVDIYQKANTFLPLDFKTLRYDFLRFLKRKYRSNNTLFNNIFNETVSRYLKIWPNDILLMTEYLCMLKRHSFKNSLDQSPKEILEKQTSFTKILETSITNYINNQIDAKVHLQTLINDKNLSIVVVELIKTTWLVLKNNMQTRKYFNLYQKNILIKNSVPFWLTYYKFEKSNVNFTKLNKFIRELGVEIYLPTTVMNDILTDYKTFYLTHSNIVTYESSIIDSNTFDPILYPELKMSNPKYDPVLNTTANVDWHKKTEWKEAGHIGITTERPQISNSIIECNSGTLIQKPISLPNFRNLEKINQVKINDLYTEEFLKEGK
The following text describes a protein:
Function:
Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway and is required for RNA-mediated gene silencing (RNAi) in the germline. Interacts with secondary 22G-RNAs in an hrde-2-dependent manner; 22G-RNAs are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'-guanosine residue. Plays a key role in transgenerational epigenetic inheritance and germline immortality. May be involved in transgenerational gene silencing both by inducing subnuclear-co-localization of target genes into heterochromatin and by activation of small RNA amplification in the nuage.
Subcellular Localization:
Cytoplasm, Cytoplasmic ribonucleoprotein granule. Nucleus. Note=Shuttles to and from the nucleus to the peri-nuclear region of the cytoplasm called nuage. Co-localizes with mut-16, probably to subdomains of the nuage known as Mutator foci.
Sequence:
MADLLDKIMGSSSSNRIPKRDNRMNQDKDEPTSKRSAPMFSTPKSTTPIGRDSFATMDTMNVQMNMFPVDIKDMPHKIQRFQVDVIVCSSNGKQINANLGVLAAKGDVNSHNRRLAQYYIMRTVHDKLLVKFSGKSHHFLAYDCAATLYLPEGVYTGDDQEEVTLTIDDFPKEEWKFVSKLSRRKDDSYLVVLKPAGFVYTQGEVAQEEANRMELTRIIEIVTSQKLNNEDYLQFGNATFPRLSPPHSEPDAISEIRSGFAKVSRLSQNGGGKAFMTVDTKISPFYKDTSVIKFSSNKLSEMKGGGGGRGGYGRSDSRDSRGGYRGGRSDSRDFRGVYGNRGGNDRYRDESRGRRDMYDSRRDSGSSNGADYSPSDAAELEHAFGERGNTKRCIEEALKGLDVECTHLKGNLIRVSSIAENNAENTSFMMKDDKGEREVTVAEYFLLQYNIKLKYPRLPLVVSKRFKHESFFPMELLRIAPGQRIKVNKMSPTVQSAMTGRNASMPQHHVKLVQDILRDNLKLEQNKYMDAFGIKLMSTEPIQMTAKLLPPAQIKFKGQTYMPDMSRPAFRTQDKFVEPARIRKIGIVVFDNCIQMRQAEDFCDKLSNFCRDNGITVEKDSRDWSIRELNSSDSVAIQNLMKKWLDDRVDILVGIAREKKPDVHDILKYFEESIGLQTIQLCQQTVDKMMGGQGGRQTIDNVMRKFNLKCGGTNFFVEIPNAVRGKAVCSNNETLRKKLLEHVQFIGFEISHGASRTLFDRSRSQMDGEPSVVGVSYSLTNSTQLGGFTYLQTQKEYKLQKLDEFFPKCVRSYKEHSKTLPTRIVIYRVGAGEGNFNRVKEEVEEMRRTFDKIQPGYRPHLVVIIAQRASHARVFPSCISGNRATDQNIPSGTCVENVLTSYGYDEFILSSQTPLIGTVRPCKYTILVNDAKWSKNELMHLTYFRAFGHQVSYQPPSVPDVLYAAENLAKRGRNNYKIHQRYVNLQAVENRIIKDHSELINEDMREELAAAIVDEMSVAMNGMTIPKRNFWA
The following text describes a protein:
Function:
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm, cytosol. Nucleus. Secreted.
Sequence:
MATVQGAVVTEDGNETKLSKNELKRRLKAEKKLAEKEAKHKELSEKQLNQASTTNHSIDNGVLADEEILDPNQYYKIRSQAIQQLKISGEDPYPHKFHVDTSLTHFIEQYNNLQPGDHLTDITVRVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRDFKSEEEFFPINNKLPRGDIFGVPGNPGRTKRGELSLIPHEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFITRSKIITYIRSFLDELGFLEIETPMMNVIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMISGMVKNITGSYKVSYHPDGPEGQAYDIDFTPPFRRISMVEELEKALGMKLPETSLFETEETRKILDDICVARDVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKNGLTERFELFVMKKEICNAYTELNDPVRQRQLFEEQAKAKAAGDDEAMVIDDNFCTALEYGLPPTAGWGMGIDRLTMFLTDSNNIKEVLLFPAMKPEEKKEASSHSGVSEGTVATATN
The following text describes a protein:
Function:
G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPGLSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTRISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTIGGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPPSVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNNCIPPVRKSVQKSVTWYTIPPTV
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MVKISEIARTSTFAWSSKNLPLLAAGTVAGAVDINFSSSATLELWDIFSPTNKTEPIFSATVDNRFYALAWSKPFEGRPQGLLAGAFENGTVEFWDADVLIKTKDLAKASVHKSNKHTGAVKSLQFNPIQNHVLVTGGSNGQIFIWDTKTFSEPFAPGQAMTPMDEITSVSWNNSVSHILASTGNGGYTSIWDLKTKREVLHLSYTGAGGRANFSYVSWHPSQSTKLITASDNDSCPLILTWDLRNSNAPEKILEGHKKGVLSLDWCKQDPTLLLSSGKDNSTFLWNPIEGIKLGEYPTTANWAFETKFAPAAPDIFATASFDGKVVVQTIQDTSPSVSTKVASTDDNEFWSELSTTETQQPVFEVKQAPNWLKNPSNVSFGFGSKLVIINTDSSGKSTVKVDKFVAKGQEKTEKLFKDLKNDNYSSLIQDKLEGETVNENNKSDWEVLKRLSETGKESLFEDANNDEKEATSPETKKENGEDDFFEHLGNGETAKKEEVFVPEGNFKIFTNNENEDSKKLINLILRNKTEEAVSSCLEQKKLVEALVLALDGSDDVKQQVKNAYFKKNKENNLSRVIYNASTKNVTDLVAHANVENWKEVAVGISSFTTDSSEYNSKMSELGDRILKAKDGKRNDAVVCYLAGGALDKISNLWLQELPDYESELLSLKSEEITSPSDARLQALTNFVEKVATYRYITKSTGEFSGPMVEPLAKAILEFVNLVAGSGDFDLANKFLQLLPSEFSGTEKERILKATSKAVEPASAVKSSANAKIAKPASSSGQTRASINAVPAPAYAPPVQAPPVQAPQPPLVQQQQQQQQQQQPNRYGYAQPTYAGAAPKTNPYARTNPYAPSNNIYKPASPVATPSSLSGTTSGVPPPPPKASYKHETEGWNDLPDTFKAKTAAPRRAAAAATPPVSTPTPVSAPAFGSPGQPPSAPSQPGSVGSVSSAGYPKKTFSATNVLPPPPKSISRSTSRTTVPTSSTVPASPKPTPVSNKYAPAVTSDASQPPSSGFASPTLNSSPRLAKNPYAPSVTEQLPPKISYATPPAHHLANNGPSTPSYAPPKNPYAVPPSTSVSHAGIAPPPPAPKLGSAAPPPPQPFGSSMSMPVQPAFNGVPPPPPPVGRAVSTPAAAKIEQPPAREPELPVQSKHPKGDRTHIPENSLPIYNSLTNVLEAIKPNIPEKYAKHGTDMEQRLNILFDHLNNEEISNGVIELLLKVATSLESKDFANATAVNLQIATEHSDEIGNWHTGLKRLITMAEAMY