lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable permease involved in the uptake of 3-phenylpropionic acid.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MVLQSTRWLALGYFTYFFSYGIFLPFWSVWLKGIGLTPETIGLLLGAGLVARFLGSLLIAPRVSDPSRLISALRVLALLTLLFAVAFWAGAHVAWLMLVMIGFNLFFSPLVPLTDALANTWQKQFPLDYGKVRLWGSVAFVIGSALTGKLVTMFDYRVILALLTLGVASMLLGFLIRPTIQPQGASRQQESTGWSAWLALVRQNWRFLACVCLLQGAHAAYYGFSAIYWQAAGYSASAVGYLWSLGVVAEVIIFALSNKLFRRCSARDMLLISAICGVVRWGIMGATTALPWLIVVQILHCGTFTVCHLAAMRYIAARQGSEVIRLQAVYSAVAMGGSIAIMTVFAGFLYQYLGHGVFWVMALVALPAMFLRPKVVPSC
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Sequence:
MAAQVCSLLSEECRVAINHIVSYELHVSDAYLSMACYYDGETKEPPFATFFEDQAEVKRAHARQFLKYLRKHESKICLPVIQRPDIDNWGTGLQALESALELENTLNKLLQDLKTLASENHETDLTGNDAASQGLHFENHSPRLSLQNSHASWESFWINKRETYAIWKTRLAIRRN
The following text describes a protein:
Function:
May be an inorganic phosphate cotransporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVLGCLPCCNHNGYQQIGNTGPRFGVRHLQCILVFFGLAVAYSLRVNLSVAIVAMTDRNASNPDFPEFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLTPFCAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIASSSLGWPSTFYIPGCVGIVWSFVWLYLCSSTPAQHPTITPNERRFIESSGQARRPSDAGREEQPRPPTPWWRIFTSVPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTVIPLGFSRKFFNTLGMWLPMLALIGLGYITEGEANVRLAIGLLTAAVATNSATYLGFHVNHIDLSPNYAGTLMGITNCAANFMSILAPLIVGLIVWDETNPAQWRIVFFFTAFVYFIGNLLFMLFGRTRVQPWNSRPTTRTPSPGGGGERDEGTEDRGPLIGA
The following text describes a protein:
Function:
Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within a specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development.
Subcellular Localization:
Nucleus.
Sequence:
MLRTPKCSRCRNHGFLVPVKGHAGKCRWKQCTCEKCYLITERQKIMAAQKVLKKQASEEELEGPELASGAAATGPGSSLRPLPLFAASRDPGPGPEGRAAASFPGRPPRGPSPGPSAFQPVLGGRGHVGPRERAAAAVPGGPQLGAEAAGRSYPGRPELRRPLRPVPSPPFADFGHSLSISSDCVVGSEYLDREPSKLYPGCSGMHPYRTFPLGYQDAGPDAGVPLQQGFRHVSCSHYHGGLVSEPLGDFQPSYYPPALPPPPPPPLPPAPFLPPGFLSALHFLPPLPPPPPPPSFSLTVVAEAHREATDDQDDQDADVPVPCEPSQPLSQEQLD
The following text describes a protein:
Function:
Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (By similarity). Contributes to centrosome cohesion before mitosis (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase.
Sequence:
MSLGLAGSLQAQLALEIVIQSLENCVLGPNQEKSLSVQNRVQDFQGASLLVCAREVIASNLSRPETPAPLQVPEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVNERLEQAVRLETGELEAQEPRGLVRQSVELRRQLQEEQSSYRRKLQAYQEGQQRQAQLVQRLQAKILQYKKQCSELEKQLMDRSTELEQQRLRDTEHSQDLDSALLRLEEEQQRSASLAQVNAMLREQLDQANLANQALSEDIRKVTSDWTRSCKELEQREAVWRREEESFNTYFSSEHSRLLRLWRQVMGLRRQASEVKMGTERDLLQLGGELVRTSRAVQELGLGLSASLHRAESKAEAALEKQKLLQAQLEEQLQAKLLREKDLAQLQVQSDLDKADLSARVTELALSVEHLQNQNSEKDQVNRTLSDKLEALESLRLQEQTTLDTEDGEGLQQTLRDLAQAALSDTESGVQLSSSERTADTSDGSLRGFSGQRTPTPPRHSPGRGRSPRRGLSPACSDSSTLTLIHSALHKRQLQVQDMRGRYEASQELLGSVRKQLSDSEGERRGLEEQLQRLRDQTAASAQAQEDAQREAQRLRSANELLSREKGNLTHSLQVTQQQAKELRQELEKLQAAQEELKRQHNQLEDAQEDSVQEGARARRELERSHRQLEQLEVKRSGLTKELVEVREALSCAILQRDVLQTEKAEVAEALTKAEAGRAQLELSLTKLRAEEASLRDSLSKMSALNESLAQDKLELNRLIAQLEEEKVALLGRQQQAEHATTMAVEKQELLEQLRLEQEVERQGLQGSLCVAEQAREALEQQILVLRSERSHLQEQLAQLSRQLSGRDQELEQALRESQRQVEALERAAREKEAMAKERAGLAVKLAAAEREGRTLSEEAIRLRLEKEALESSLFDVQRQLAQLEARREQLEADSQALLLAKETLTGELAGLRQQVTSTEEKAALDKELMTQKLVQAEREAQASLREQRAAHEEDLQRLQHEKEAAWRELQAERAQLQGQLQQEREELLARMEAEKEELSKEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLAAISLEMERQKRDAQSRQEQDRNTLNALTSELRDLRAQLEEATAAHAQTVKELEERTGNLGRQREACMREAEELRTQLRVLEDTRDGLRRELLEAQRKGRDSQDSSEAHRQEASELRRSLSEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARVSVAKEAGELRASLQEVERSRLEARRELQELRRQMKTLDSDNGRLGRELADLQGRLALGERTEKESRREALGLRQRLLKGESSLEALKQELQGSQRKLQEQEAEFRARERGLLGSLEEARGAEKRLLDSARSLELRLEAVRAETSELGLRLSAAEGRAQGLEVELARVEAQRRVAEAQLGGLRSALRRGLGLGRVSSSPAREAPAGGSGDGLSSPSPLEYSPRSQPPSPGLIASPAPPDLDPEAVRDALRDFLQELRSAQRERDELKVQTSTLSQQLVEMEAERDHAASRAKQLQKAVAESEEAWRSADRRLSGAQAELALQEESVRRSKRECRATLDQMAVLERSLQATESELRASQEKVSKMKATEAKLESDKRRLKEVLDASESRSIKLELQRRALEGELQRSRLGLGDREAHAQALQDRVDSLQRQVADSEVKAGTLQLTVERLSGALAKVEESEGNLRSKVQSLTDALTQSSASLSSTQDKNLHLQKALSTCEHDRQVLQERLDAARQALSEARRQSSSLGEQVQTLRGELASLELQRGDAEGQLQQLQQALRQRQEGEAMALRSVQKLQEERRLLQERLGSLQRALAQLEAEKRDLERSALQFDKDRVALRKTLDKVEREKLRSHEDTLRLNAERGRLDRTLTGAELDLAEAQQQIQHLEAQVDVALEGNHNPVQPEAGEQQLELQQEVERLRSAQVQTERTLEARERAHRQRVSGLEEQVSTLKAQLHQELRRSSASVSLPPGTPEK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MAVYRCGKCWKTFTDEQLKVLPGVRCPYCGYKIIFMVRKPTIKIVKAI
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MNNRKDHELVGKRTRFMMNNINNSNSNNGSSHSHDVTVPSSLMSHLQNQSIFNPQAHSNGFPFWSSDEIINNNDHHHHQLSLDLSAMTLLDEDHHQQHSQPSNVVNNMSRIRGNNSNNNLVEPFTNMPCFWESHAYNNNNVVDDETVTVTHPRYQNMGGGGGSPKASTFGVSQNPQGLVSENIKWGMQKGHTFTGISQMGSSIDLGNNVPYGNGVCYGRGRGRVVPVQLQNPSFSSPYNPYEQHVVYPSPRGSSFGMENDLGSWDVTTNPIMYTTTPNVNNVPSTPLYFPSNRGLQQLPQSLYPTRPIEEPVAFKCDNSFIFQENDMKNECNNSLLAGSGVGGGGRKFSVSHSQEAVIPQVSHLPSRSENSSRSFVFDDDDVQQNLMNFGSCLPELQSYMFHMAKDQNGGRFLQGMVEKGTVEDMEMVFNGVIDNVVELMMDPFGNYLVQKLLEFCRDDQRLQIVLMLTKVPGQLVRTSFNTHGTRSVQKLISTLKSRRQIALVRSAILPGFLDLVKDLNGNHVIQRCLSCWSVQDNEFIFDAATKFLTDVATHQHGCCVLQRCIDFSKGKSLEKLVKEICKHGFSLAQDPYGNYVIQYIIELQIPSAMAKLTPQFKGNYVILSTQKFSSHVVEKCLIYIVETRARIVQELLSVPHFERLLQDPYANYVVQKALEYTKGSLHASLVEAVRAHKILRTSPYCKRIFSKTLPKK
The following text describes a protein:
Function:
Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasmic vesicle. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Sequence:
MAAAPPLRDRLSFLHRLPILLKGTSDDDVPCPGYLFEEIAKISHESPGSSQCLLEYLLSRLHSSSGHGKLKVLKILLYLCSHGSSFFLLILKRNSAFIQEAAAFAGPPDPLHGNSLYQKVRAAAQDLGSTLFSDTVLPLAPSQPLGTPPATGMGSQARPHSTLQGFGYSKEHGCTAVRHQPGQAGGGWDELDSGPSSQNSSQNSDLSRVSDSGSHSGSDSHSGASREPVDLAERVEVVALSDCQQELSLVRTVTRGPRAFLSRKEAQHFIKACGLLNCEAVLQLLTCHLRGTSECTQLRALCAIASLGSTDLLPQEHILLRTRPWLQELSMGSRGPVTNKATKILRHFEASCGQLSPARGTSAEPGPTAALPGPSDLLTDAVPLAGSQVFLQPLSSTAVSSRSPAPSSGMPSSPVPTPPPDASPIPAPGDPSEAEARLAESRGWRPERIPGGTDSPKRGPNSCAWSRDSLFAGMELVACPRLVGAGAAAEESCPDAPRAPRTSSQRTAAKEPPGSEPSAFAFLNA
The following text describes a protein:
Function:
This enzyme is required for electron transfer from NADP to cytochrome P450.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MASLLTLQTQPNTIDYIALTFLSLVAGTFLTRGILWDQPDPYRHLLYERPQLKHGIGTTANSRQQTRNIARRLEETNSPIVVFWGSQSGTAESFAHRLAREITLRFGQNTLTADLSDYDPASIAEIPSSKLAIFILSTYGEGDPADNTVEFWNWLNSNDRNAEKKQKQFSGLRYFAFGLGNSNYKFYNRVIDRVVKVLGEHGANALLPVSRANDATGSTQEDFISWKERLFAFFRGSLGFTQSELIYQPTISITTDDTIKPSALHRGEPRHSPNPVAIPIMGIRQLFEPISDRYCLHIDLDISSTPGVVYKTGDHLAVWPSNPDEEVKLLLHMLGRSHESEIPISIAPIEGADVEDVAKKVPSPTTLLVLLRHYLEITAQLPRDILATLAPFAPTNEAKTFLTELANSKEAYADFTRRNHLTLARVLAASSTNKQRWTSLPLTYIIETLPVLQPRYYSISSSSVVSPRKISLTVLVLSTPLPENTAMSIQGLTSTYLLTLADSPQSREHKNMTLPTYTNTLLPFTPDSSSDGRRRILAHLRRSSFKLPRLQTTPLILIAAGTGLAPFRAFIAERRQVLKIGREVGDVLLFFGCRSPEEDFIYKDELSEMEGAFGGKLRIVTAFSRYGQRSERAYVQDRVLEYKNEVREILVARRGNLYICGRAGMAREVERRVTGFLTEMEDGWSDRDAEEWVRSVKRRNKWQEDVWG
The following text describes a protein:
Function:
May act as a tumor suppressor.
Subcellular Localization:
Secreted.
Sequence:
MLLLLGLCLGLPLFSESQEEARSWDDTSEQVVLRVPRQLRLLQRLKTKPLMAEFSVKSTIISRYAFTTVSCRMLNRASEDQEAEFQMQIPESAFITNFTMLIGDSVYRGEITQKDKKSSESVKDKRNRTSDDNEENGSDMFKASLVIPSKDKAAFFLSYEELLQRRLGKYEHSISVRPQQLVGRLTVEVDILERSGITSLEVLPLHNSRKKGSGKAEGDVGPPPSTLINQNETFAKVIFKPTVVQQAKIAQNGILGDFIVRYDVEREQNIGDIQVLNGYFVHYFAPKNLPPLPKNVVFVLDISASMVGAKLQQTREALVTILNDLRPQDRFNIIGFSNRIKMWKDHLLPVTPDNIRNGKIYMYHLSPTGGTDINGALQAAIKLLNNYVAQNDIEDRSVSLIIFLTDGKPTFGETNTLKILSNTKEATRGQICIFTVGIGDDVDFKLLEKLSLENCGLTRRVHEEDKAGAQLIGFYDEIRTPLLSDIRIDYPPDVVEHATKTLFPNYFNGSEIVIAGKMVDKKFDQLHVEVTASNSKKFVILKRDIPVEFRKMGNDVSVTPGSARDGGKDLNHIERLWSYLTVKELLSSWRQSNSEQEKEQLRQKAQDLALNYHFLTPFTSMKLRKPGLRTNQLEDTYGMSAATGPATVVQNLREAGKQPEPDLKKTYDPRIKISKTSVDGDPHFVVDFPLSKLTVCFNIDGEPGDILRLVSDHLNSGVTVNGELIGAPAPPNGHKKQRTYFRTITILINRPERSYLEITPSRVILDGGDRLVLPCNQSVVVGSRGLEVSVSANANITVVIQGNIAFVILIHLYKNPAPFQRDHLGFYIANSRGLSDNCHGLLGQFLNQDAKLVGAPEEYGKNLSNQPFPRAEGMPEAILKVKGRRVPVVWKQRKIYNGQAQVDCWFDRNNAAKLIDGVYKDYLASHPFDTESALGLSTPRKPETDRPHEESV
The following text describes a protein:
Function:
Serine and threonine phosphatase. Has a specialized role in the heat shock response. May be responsible for the dephosphorylation of hsp90.
Sequence:
MKGSHPNAGSLLEPLHKLNPFSENSTSGHRKNASDHSADGETRPIAIEMKDSKGNTVPVGNSRPSKASNWLAGLMEDKNQRWRRSMEDTHICLYDFGGNQDDGFVAVYDGHAGIQASDYCQKNLHKVLLEKVRNEPDRLVTDLMDETFVEVNSKIAKATHNDICGCTAAVAFFRYEKNRTRRVLYTANAGDARIVLCRDGKAIRLSYDHKGSDANESRRVTQLGGLMVQNRINGVLAVTRALGDTYLKELVSAHPFTTETRIWNGHDEFFIIACDGLWDVVSDQEAVDFVRNFVSPREAAVRLVEFALKRLSTDNITCIVVNLTRNPGDLDDSGLTADNDSYSNDYY
The following text describes a protein:
Function:
Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
Subcellular Localization:
Secreted.
Sequence:
MPSLPAPPAPLLLLGLLLLGCRPAHGAGPEPPALPIRPEKEPLPIRGAAGCSFGGKVYALDETWHPDLGEPFGVMRCVLCACEAPQWGRRARGPGRVSCKNIKPECPTLACVQPRQLPGHCCQTCPQERSGAERQPTGLAFEYPRDPEHRSYSDRGEPGSEDRARGDGYTDFVALLTGPRSQAVARARVSLLRSSLRFSISYRLLDRPTRIRFSDSAGSVLFEHPAAPTQDGLVCGVWRAVPRLSLRLLRAEQLHVALVTPTHPSGEVWGPLIRHRALAAETFSAILTLEGPPQPGMGGIALLTLSDTEDSLHFLLLFRGLLESRSGGPTQVPLRLQILHQGQLLRELQANASVQEPGFAEVLPNLTAQEMDWLVLGELQMALERAGGPGLRISGHIAARQSCDVLQSVLCGADALVPVQTGGAGSASLTLLGNGSLIYQVQVVGTGSEVVAMTLETKPQRRNQRTVLCHMAGLQPGGHMAVGVCPGLGARGAHMLLQNELFLNVGTKDFPDGELRGHVAALPYSGHSARHDTLPVPLAGALVLPPVQSQAAGHAWLSLDTHCHLHYEVLLAGLGGSEQGTVTAHLLGPPGMPGPRRLLKGFYGPEAQGVVKDLEPELLRHLAQGTASLLITTKGSPQGELRGQVHIANQCEVGGLRLAAAGAEGAWTPGSPDAAAAALPGVPAVSAPTPAKPGGPGRPRDPNTCFFEGQQRPHGARWAPNYDPLCSLCTCQKRTVICDPVVCPPPSCPTPVQAPDQCCPVCPEKQDVRDLPGLSRTRDPGEGCYFDGDRSWRAAGTRWHPVVPPFGLIKCAVCTCKGGTGEVHCEKVHCPRLACAQPIRANPTDCCKQCPVGSGAHPQLGDPMQADGPRGCRFAGQWFPESQSWHPSVPPFGEMSCITCRCGAGVPHCERDDCSLPLSCGPGKESRCCSHCASRRAAPETRTVPELEKEAEGS
The following text describes a protein:
Function:
Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.
Sequence:
MDTKNPGPTGGLHRPDLIKIPRLYQTELLEEAKKRNIIIRADTGTGKTIVAVNLIAWTAVKTKAKNKNHQIQAFLVPTRPLAHQQAEYIQKHCTLRIKAYTGDLQPELWNIRKWHSELNEVDVLVSTAQIFYDLISKGYWKLEDVSLLIFDEAHHCRKNHVYNQIMRSHYHRLAKDSTVRLPKILGLTASPIWNFKDLEKAESDIKSLQSALAAQIYEVKKHTEDVCRHNFKPNEQVVYFEPAPDFQQLPHPPWDQINKLLSLHASPKMIAAVESVSLDLGTYAYSLAVLDWLKSLLTIGGSNQLMSGRLVDPNYQERIQSLIKEVEKLVDIDDIPENQLSSKVIALYKILVNYKEKDDHNNFLCIVFVERRQHAQLLPILLERNVQLKDFLRPAALTGHGSGNENDLIGIKMDSRTQNRTVAKFRTGEHNLTIATSVAEEGLDFRSCRVVIRFDLITTWKGYIQSRGRARARESDYIVMLPTGTANKYLAFSGKEEQLKAALYDRPQDELIEDGEEESTPQLICQLADGKESILTYSAATSLLNDVCQLIPPDEFLPVVAPEYEMMELGERFKCRVTLPPMAALPPSRRTFTGLEMGTKNGAKRSAAFEACKVLRELGVLNEHFLPQREDKAAQVRDADGREIETTQLADKVEAIISNIYGDFRTSSEVWLHKLSFPDDSPAGFSTMGLLCARHLTIPDDLQLFDHDPVSRPLSVKIKHSKKVEWEQDDAPFNLQRLERFTLLVMQVAVNRKPYEGKLYFLVAPLLNDAIEIDWNLVDTPMIPLSEAADSSRYQCTIVPSRRPRFRIFDTCESAGDLCAASPPSRVPACPSMQHFCKKIAKFHNLGHFYKTCYDLEDEHLKGDFVYLQTTFQVYNNLLQSVSTLAHPYRTLLPLKLCQGTHIPRTIWKVFSYLPSLTRLLHDSIQATALFMRLDFPMTLLPRGIQALTPPGVGVPWDYQTLETVGDAFLKLATSVHVYLSHLRKGEGDMSHVRSKSVDNDYLRRKAIQANLPSSILGQRFRTDRFRDAQTEDGKELPNGNFSRNVPRRVLSDVVEALLGAGFLTGGIELGLKIGTALDLCFGGTTPWNERTLNIAFEGTAHDKLASSILLKCQALEEKIGYVFKEKLLLVQALTHRSANSFMTNCYEREEWLGDAVVDMWIVQHAYKRFDNATAEELTLARAKLVSNGSLGFLAIKKLGLHKVIMHKSESFEQACVEAIKAIEPFTSIEEFFSNLENLFVVFDPPKILNDVLEAIVGAVFIDSRFDLPTVYRTIDKIFEDVTPGLSRIVARDPLSTMLRLRDQYQCAELRRVSTTIKEPNPEGEDKDPISVRVCRIELHGQEIASGRHASSASVAEQRASLAALKVLQDPSGDSPAPKSAWLGCQCKARAVSTTAVASSTPAAENKEEIQKEEGSHASQDLPRQMSHLHM
The following text describes a protein:
Function:
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.
Sequence:
MLSICGRAMFNPLRFITRTANRITHCKRDLTKLSYFHKPGKDQLLPWTVGHLIDRATERIGDTTAIVYSHQNISKTYTEYRKDVDQLAAGLVSLKLPEGSRVAILVPRLYEGAQLLYAASKAGLVMVGINTFCTVSELEFCLNKTESAALILADKFTDKNFYETLLQIAPEMERSAPGELSSQRLPFLKHVITIGDIRKPGSITFDDLINSGTAEHHVAMNAVSAKVQFDQDAFIQFSSGTTGEPKPVRLSHFNVVNNANIVGRFIGYHQQPESICLNGELIYGFGRTLGVLAATMFGCTVMMPGLAFSPKATLETIANHRCTVAYATPSMLFEMMRELEQGSYDVTSLRKGVLSGSVCNPTLAEKARTKLNVQSLYIMYGATETSPIFSSTNPDEPKDCWIRTVGTPLDHVEVKVVDAEGKIVPVNTRGELCTRGPHVFKGYLNDDAKTKEAKRDGWYHTGDEGKMSEDGRITFVGRMKEIINYRGLKVPPLEVENVLNMHPDVKEAQVIGVPDETVGEKICAWIELQPNKSLIQEEIKAFCKDKLSWFMVPEHVLFVNSFPRTQTGKVQKHKMREESVRLFKQ
The following text describes a protein:
Function:
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. Required for recruitment of CPLANE2 to the mother centriole. Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate (By similarity).
Subcellular Localization:
Cytoplasm. Cell surface. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Enriched at the apical surface in ciliated cells. Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Recruited to the centriole in a TTBK2-dependent manner.
Sequence:
MADPARRDPRGRAPELPGDLSSQEEEEEESDSDAGASSLGSCSSASSDTDLEPEWLDSVQRNGELFYLELSEDEEESLLPETQTVNHVNHVRFSEKEVIIEEDDSRERKKYEPKLRRFTKILKSKSLLPKRHHKKKSSNTGPVSILKHQSTQRTGVTVQQRYKDVTVYINPKKLTAIKAREQAKLLEVLVGVIHQTKWSWKRSGKQADGERLVVHGLVPGGSAMKSGQVLVGDVLVAVNDVDVTSENIERVLSCIPGPMQVKLTFENAYAVKKETAQPKKKKAQSSTNDLVKLLCGSEADATQHSTLSIPHITMYLTLQLQSEVAREEQEMLYHYPVSEASQKLKSVRGIFLTLCDMLESVTGTQVTSSSLHVNGKQIHVAYLKESDKLLLIGLPAEEVPLPQLRNMTEDVAQTLKFMYGSLDSAFCQVENTPRLDHFFSLFFERALRPGKLHLSASPSAQQYDAASAVLLDNLPGVRWLLLPQELKVELDTALSDLEAADFQELSEDYYDMRRLYTILGSSLFYKGYMVCSHLPKDDVVEIAAYCRQYCLLPLAAQQRIGQLIIWREVFPQHHLQPATDSDPEAFQEPEGRYFLLIVGLRHYMLCVLLEAGGCASKATGNPGPDCIYVDQARATLHQLEGVESRIEEQLAATPGPCLSCADWFLAAPREKADSLTTSPILGRLQGPSKTAASPTCRRTFFSDYSFKARKPSPSRIGGGREPGEGEENVGLSPHTTPDTVRKQRESEGSDDNVALLKLARKKSTLPNPFHLGTSKKELSEKELEVYNMMKLTSGPENTLFHYVALETVQGIFITPTHEEVAQLGGSVHSQLIKNFHRCCLTIRAVFQQTLKVEKKKALSDGDHLESANSVSSLSPVKEHGVLFECSPENWTDQKKTPPVMSYWVVGRLFLNPKPQELYVCFHDSVSEIAIEMAFRLFFGLTL
The following text describes a protein:
Function:
Probably participates in deamination of adenosine-34 to inosine in many tRNAs.
Sequence:
MAPSADGPGISPTWHPIPVLSVEEEQELREAEAGYISPPLTAVFAAPILDKRQISRLSQAICSEYPLPEMLRFLKRVRCCASRHEFLLRLATKGEEEDVLKPRVNQSDSELADLAKSQNNVYSSDSWTVPSLTDIFLDKVFDLQGLGDPFLVYVPARAPRNPKEQQLWSGYWPSTYHAKGKAEVNAEESLRGKQISEEERSRIGRYMGTAVEAARASQARGGKGVGAVVVDPRNGEVLAISSDRTDEDGGPLLHACMVAIDMVARKQGGGAYACLKESNGELGMARDRITDKRNRQFIHTEETGEKLEQGDIEGGNNNEQSDILRDITDGAKRKRLEESTEGEEVPYLCTGYEIYVTREPCVMCAMALLHSRIFSVYYGCATPGGALGTCYRLHCGPGLNHRFQVYRGIMEDECQKLICPGNS
The following text describes a protein:
Function:
May be involved in a late step of spore wall assembly.
Subcellular Localization:
Cytoplasm. Prospore membrane. Note=In mature spores. Localized around the prospore membrane during meiosis II.
Sequence:
MEENQLTCLIVGETPAAQFLGWRLSLSNSFIILVSQYVSSDELVAWKSTKLGANFYTPNILTKDIKELHHKLKHNGANTYSIDIVLVSAISLQSFETTCRLLSDYTNDNTTVLISTDFGCELEPIAISYFGGKCKCVISISCEVECRQLSLGSYALVNDDQCVITLGLTYCDANFEASPTILENTKAASLELQGIKGSNVRRFLLGLTVAKWMKSKLILDPKQMALKMWELLIPKISLNILSIIYEQFDYEKMLENKSTEIIFKDLVKELLGICFAQCGSKIARFLLVKSQGEEEINFGKIVEYCKGKKLQLINSTANEHPEYLSLPFEPYCFYHRFEYPAQILLHQPIILAKKYGVSCSNLNFLYGFYTRLLTLSGLSINGGRCEHALSMLDSRIGGGINVASGINSGQDFTDGDNEDQDKGKNRVDKNVKEGSFISLTQRFTMTSPLGVNDPALPADLEKLYLGAEYISNCDANTSGGQKRVKSPTKADTGYDDKHLPDDTIHTFEDEYLADEDDFSCLGIDKRSSTKPTKPLEKFGVVAVPHFIRRFSIKRSSKDKSNDMKRPYTTSSLELQLRSNHFMFAKEYQDLHRQLYYEVKPRTQSELDARRRNYSELESQMWKIKHRFNIHRGALPRPRTNPYELLLDHIDVLNRGNTGDILRFTTSRYGGVDTYDSILRDQSTIMELLDKRCAYSPPVLFDNEAKERDHDRDCYQDYNHDHRSH
The following text describes a protein:
Function:
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.
Subcellular Localization:
Nucleus.
Sequence:
MMLSVKPQRHFGPEPRSACLRTTNLGEKHQEGCINEGTACRLATAVIRSVLEHRRAIEKLATLAVRKNPRLSFLHVVMETQHGTPSTDSVIEGNNFPVHETEIMDNCIFSGVNDGLDIASQAAEKMHQNDNISNTDEQEKVDAPVLEICEPVGKPALDQNSTCHQEQEERMEVTVQLENLNFKNEASMIKAEDNNETKDSSSEDSSSDSDTDSDSSSSSSSILLPVEEEEVPNANNDLPLKTKGELLINELPAVEELSIVLPEDVELKPIGMVSSIIEQLVIIESMKDVPPLNEDSVIFNEGRNAVGKIFEIFGPVPHPFYVIRFNEKGQIENKGIKIKDTMFFAPKVEDFTQYIIPDKLKIQKGSDASWTNDHEPPADVLDYSDDEKEREAKQKKKGNNLAKKKIQSDQDENSSSVHEQNRNYRGQNVSRPPSRHNYGPRFSRGRAAQLHNNAFGQHPRTYFQPGFPSPHMMNQPYPFHSMQAQEYSSALPSNGHGTPVSHYYSSPYGHVHPYSLPPPPPPPPDMIWSEQNNPLHFMQNSQFYTSPPPPPPPPPLGNPNQSSFDPNYN
The following text describes a protein:
Function:
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGVKKKLKLTSLLGLSLLIMTACATNGVTSDITAESADFWSKLVYFFAEIIRFLSFDISIGVGIILFTVLIRTVLLPVFQVQMVASRKMQEAQPRIKALREQYPGRDMESRTKLEQEMRKVFKEMGVRQSDSLWPILIQMPVILALFQALSRVDFLKTGHFLWINLGSVDTTLVLPILAAVFTFLSTWLSNKALSERNGATTAMMYGIPVLIFIFAVYAPGGVALYWTVSNAYQVLQTYFLNNPFKIIAEREAVVQAQKDLENRKRKAKKKAQKTK
The following text describes a protein:
Function:
Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPVAPRSGSSIDGVTGSSPPRYERLPSPIELMRGSSEDMLPAASAAAAAAAAEEEGPEQDDSSVADGPGSLSYGDERTALLGGGGTGGGSAFSNAVAALTGAAARGRTPTSLTPHHPHSHQHPHQHHPHQHGSGHAHPPHPPSSHGHAPHAYSHGFAAGSGPGPSLLATAAGGLLLPAPHPHHDHHKRHSASGGTDSAGSMAGDLEAGPRVRRFSSASSPQSRWQSTAKRVMHGINTMHAIDEAMERHEPGAAPGIDPRRAKYAHLAAKWCLPVRVTCVDYDSKEVTITPDLLSAEDLSAFLAANPRPARPGPGGGGGGGGGAGDGGGGGAASGAAAAAAALAGGGGGLNGSATGRVRWIHVDGLNWEVIQLLALTYDLHPLALEDTVHVPQRIKGDFYDSCLYISLIYLYLAAGAADTPDAASDGAAAARAAAAAAAAAAAAPHTPSATPTAARRMARTISGVRRADAAAAAAALAASGASDNDRSVGGGGGRAPLASAASAASGSSSGYNVVLNALASFASGNSVTNGGGQKPSQPGPSHYPLPLRRGSVVVSSAADFHVVGEADEARGGGDGSPTEAARAETAAAVAAARPPPARGGSKSPGGNRPSFSIASRAAAGGGGGGGGGWGRGGGGGGGGGHMEHGGRDIHVSAQQVSLFLLRGEHANTLITIFQSDGSDVTRPILAQLREPRTLVREAEDASFLANLVIDTLVDHIFPVVGAYTEQLQQYEAAVMAPGGQLPSAASTRELHAMQRDLRRIDRTIAPMQAVVANIIARDAAAEESAAARRQQLQACGLELADGAAAGGVAPFLSRLTRIYMGDVKDHVSTICEDLMSLSAECGDLIGLIFNLTTHQQSQYAQTLAVVSTIFLPITFLAGVYGMNFDILPELHWQYGYAYFWATSTIIVVVFICVMLRAGLWSV
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body.
Sequence:
MSKRRLGRLAKMTEDQKILYLEKQRLAEEEMRRDKEELLAQYLKNKMAKEEKMSQENWYKLNQQWREILRGTKSKELKKEIEILSQVFERAVDIKSSALQTVLKDLAEAEEQFLMAKRSHMHNVDKLLDFQRRHMNQMDTDYKDQVESLKQEFESEKALLTEQHRQKVIRLEGLIFAMEDNFFEKEEEEKAEFQSNMDELKNRNLEDIHSLRLRQELLLESLWNKFLAACKYYHDATEDRKKSFDELKEKDDKNAGEMEAQAKKIENLQVKNCTTIIIIITVKIFSAKKKPKQEKEMLASSLYCLKKALVETQMIEKDRLAKLVVVVSEVQKRMKRTIEQGEHLLKAAERCRRLESEGEKILPFYQSTLDDSDLNRIEEIMKEEAEERLTKLMHSYTNLDNFWKRFNKVAVEKSALEKEIGHLTEINQALKRHIKCEIKEHFSTPDLKQLMKNMEGGGQEGKEKSVDCGLPELKIVAKTIEDT
The following text describes a protein:
Function:
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.
Sequence:
MAAEQQPELQGLSDEVAYSLCSDPHPLTKDFMLQQTMLRIKDPKKSLEFYTNVLGMTLLQKFDFPSMKFSLYFMAYEDKKDIPADVNERTAWTFSRKATLELTHNWGTENDEKPYHNGNSDPRGFGHIGLAVPDVYAACKRFEELGVTFVKKPDDGKMKGLAFIQDPDGYWIEILSPNTMLSII
The following text describes a protein:
Function:
Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
Sequence:
MAEFSTSEDLFAHARGNESNERFYNLCFWGRNNPPSAMPCSQYTTQFISSRGNEYFCEIDEEYLTDRFNLTGLNTEVPYYQYALDLVTDVFDLDADDDLREQIEKSARHLYGLVHARYIVTTRGLGKMAEKYKNGDFGKCPRVLCEGQHLLPMGLHDIANQSTVRLYCAKCEDIYNPKSSRHSSIDGAYFGSSFHSIFFQVFPNLVPPKSTRRYEPRIYGFRVHASAALARWQDRYREQMRSRLNEAGVEVKYAEDSEVEDDDEEDSEGEDQASEVKEEKLLGDAASGRMDLGN
The following text describes a protein:
Function:
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Subcellular Localization:
Cytoplasm.
Sequence:
MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRALMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPLRLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKESNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKNMSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT